data_7I2C
# 
_entry.id   7I2C 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   7I2C         pdb_00007i2c 10.2210/pdb7i2c/pdb 
WWPDB D_1001408227 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-02 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.entry_id                        7I2C 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.recvd_initial_deposition_date   2025-03-06 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.SG_entry                        ? 
_pdbx_database_status.pdb_format_compatible           N 
_pdbx_database_status.methods_development_category    ? 
# 
_pdbx_contact_author.id                 1 
_pdbx_contact_author.email              fr193@cabm.rutgers.edu 
_pdbx_contact_author.name_first         'Francesc Xavier' 
_pdbx_contact_author.name_last          Ruiz 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-0457-0030 
_pdbx_contact_author.name_mi            ? 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Aschenbrenner, J.C.' 1  ? 
'Saini, M.'           2  ? 
'Chopra, A.'          3  ? 
'Marples, P.G.'       4  ? 
'Balcomb, B.H.'       5  ? 
'Lithgo, R.M.'        6  ? 
'Fearon, D.'          7  ? 
'von Delft, F.'       8  ? 
'Ruiz, F.X.'          9  ? 
'Arnold, E.'          10 ? 
# 
_citation.id                        primary 
_citation.title                     
'Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_volume            ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.year                      ? 
_citation.journal_id_ASTM           ? 
_citation.country                   ? 
_citation.journal_id_ISSN           ? 
_citation.journal_id_CSD            0353 
_citation.book_publisher            ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_DOI      ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.identifier_ORCID 
_citation_author.ordinal 
primary 'Aschenbrenner, J.C.' ? 1  
primary 'Saini, M.'           ? 2  
primary 'Chopra, A.'          ? 3  
primary 'Marples, P.G.'       ? 4  
primary 'Balcomb, B.H.'       ? 5  
primary 'Lithgo, R.M.'        ? 6  
primary 'Fearon, D.'          ? 7  
primary 'von Delft, F.'       ? 8  
primary 'Ruiz, F.X.'          ? 9  
primary 'Arnold, E.'          ? 10 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'NS5 RNA-dependent RNA polymerase'                                  73890.008 1   ? ? ? ? 
2 non-polymer syn 'ZINC ION'                                                          65.409    2   ? ? ? ? 
3 non-polymer syn '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'                              195.237   1   ? ? ? ? 
4 non-polymer syn 'DIMETHYL SULFOXIDE'                                                78.133    3   ? ? ? ? 
5 non-polymer syn 'DI(HYDROXYETHYL)ETHER'                                             106.120   2   ? ? ? ? 
6 non-polymer syn 'PHOSPHATE ION'                                                     94.971    2   ? ? ? ? 
7 non-polymer syn '3-fluoro-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzene-1-sulfonamide' 283.322   1   ? ? ? ? 
8 non-polymer syn 'CHLORIDE ION'                                                      35.453    1   ? ? ? ? 
9 water       nat water                                                               18.015    398 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;GPGIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAM
TDTTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAR
EAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENS
LSGVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRP
TPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGD
DCVVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQG
AGWSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPW
MEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_entity_poly.pdbx_seq_one_letter_code_can   
;GPGIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAM
TDTTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAR
EAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENS
LSGVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRP
TPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGD
DCVVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQG
AGWSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPW
MEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'ZINC ION'                                                          ZN    
3 '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'                              MES   
4 'DIMETHYL SULFOXIDE'                                                DMS   
5 'DI(HYDROXYETHYL)ETHER'                                             PEG   
6 'PHOSPHATE ION'                                                     PO4   
7 '3-fluoro-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzene-1-sulfonamide' A1BZP 
8 'CHLORIDE ION'                                                      CL    
9 water                                                               HOH   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   PRO n 
1 3   GLY n 
1 4   ILE n 
1 5   GLU n 
1 6   SER n 
1 7   GLU n 
1 8   THR n 
1 9   PRO n 
1 10  ASN n 
1 11  LEU n 
1 12  ASP n 
1 13  ILE n 
1 14  ILE n 
1 15  GLY n 
1 16  LYS n 
1 17  ARG n 
1 18  ILE n 
1 19  GLU n 
1 20  LYS n 
1 21  ILE n 
1 22  LYS n 
1 23  GLN n 
1 24  GLU n 
1 25  HIS n 
1 26  GLU n 
1 27  THR n 
1 28  SER n 
1 29  TRP n 
1 30  HIS n 
1 31  TYR n 
1 32  ASP n 
1 33  GLN n 
1 34  ASP n 
1 35  HIS n 
1 36  PRO n 
1 37  TYR n 
1 38  LYS n 
1 39  THR n 
1 40  TRP n 
1 41  ALA n 
1 42  TYR n 
1 43  HIS n 
1 44  GLY n 
1 45  SER n 
1 46  TYR n 
1 47  GLU n 
1 48  THR n 
1 49  LYS n 
1 50  GLN n 
1 51  THR n 
1 52  GLY n 
1 53  SER n 
1 54  ALA n 
1 55  SER n 
1 56  SER n 
1 57  MET n 
1 58  VAL n 
1 59  ASN n 
1 60  GLY n 
1 61  VAL n 
1 62  VAL n 
1 63  ARG n 
1 64  LEU n 
1 65  LEU n 
1 66  THR n 
1 67  LYS n 
1 68  PRO n 
1 69  TRP n 
1 70  ASP n 
1 71  ILE n 
1 72  ILE n 
1 73  PRO n 
1 74  MET n 
1 75  VAL n 
1 76  THR n 
1 77  GLN n 
1 78  MET n 
1 79  ALA n 
1 80  MET n 
1 81  THR n 
1 82  ASP n 
1 83  THR n 
1 84  THR n 
1 85  PRO n 
1 86  PHE n 
1 87  GLY n 
1 88  GLN n 
1 89  GLN n 
1 90  ARG n 
1 91  VAL n 
1 92  PHE n 
1 93  LYS n 
1 94  GLU n 
1 95  LYS n 
1 96  VAL n 
1 97  ASP n 
1 98  THR n 
1 99  ARG n 
1 100 THR n 
1 101 GLN n 
1 102 GLU n 
1 103 PRO n 
1 104 LYS n 
1 105 GLU n 
1 106 GLY n 
1 107 THR n 
1 108 LYS n 
1 109 LYS n 
1 110 LEU n 
1 111 MET n 
1 112 LYS n 
1 113 ILE n 
1 114 THR n 
1 115 ALA n 
1 116 GLU n 
1 117 TRP n 
1 118 LEU n 
1 119 TRP n 
1 120 LYS n 
1 121 GLU n 
1 122 LEU n 
1 123 GLY n 
1 124 LYS n 
1 125 LYS n 
1 126 LYS n 
1 127 THR n 
1 128 PRO n 
1 129 ARG n 
1 130 MET n 
1 131 CYS n 
1 132 THR n 
1 133 ARG n 
1 134 GLU n 
1 135 GLU n 
1 136 PHE n 
1 137 THR n 
1 138 ARG n 
1 139 LYS n 
1 140 VAL n 
1 141 ARG n 
1 142 SER n 
1 143 ASN n 
1 144 ALA n 
1 145 ALA n 
1 146 LEU n 
1 147 GLY n 
1 148 ALA n 
1 149 ILE n 
1 150 PHE n 
1 151 THR n 
1 152 ASP n 
1 153 GLU n 
1 154 ASN n 
1 155 LYS n 
1 156 TRP n 
1 157 LYS n 
1 158 SER n 
1 159 ALA n 
1 160 ARG n 
1 161 GLU n 
1 162 ALA n 
1 163 VAL n 
1 164 GLU n 
1 165 ASP n 
1 166 SER n 
1 167 GLY n 
1 168 PHE n 
1 169 TRP n 
1 170 GLU n 
1 171 LEU n 
1 172 VAL n 
1 173 ASP n 
1 174 LYS n 
1 175 GLU n 
1 176 ARG n 
1 177 ASN n 
1 178 LEU n 
1 179 HIS n 
1 180 LEU n 
1 181 GLU n 
1 182 GLY n 
1 183 LYS n 
1 184 CYS n 
1 185 GLU n 
1 186 THR n 
1 187 CYS n 
1 188 VAL n 
1 189 TYR n 
1 190 ASN n 
1 191 MET n 
1 192 MET n 
1 193 GLY n 
1 194 LYS n 
1 195 ARG n 
1 196 GLU n 
1 197 LYS n 
1 198 LYS n 
1 199 LEU n 
1 200 GLY n 
1 201 GLU n 
1 202 PHE n 
1 203 GLY n 
1 204 LYS n 
1 205 ALA n 
1 206 LYS n 
1 207 GLY n 
1 208 SER n 
1 209 ARG n 
1 210 ALA n 
1 211 ILE n 
1 212 TRP n 
1 213 TYR n 
1 214 MET n 
1 215 TRP n 
1 216 LEU n 
1 217 GLY n 
1 218 ALA n 
1 219 ARG n 
1 220 PHE n 
1 221 LEU n 
1 222 GLU n 
1 223 PHE n 
1 224 GLU n 
1 225 ALA n 
1 226 LEU n 
1 227 GLY n 
1 228 PHE n 
1 229 LEU n 
1 230 ASN n 
1 231 GLU n 
1 232 ASP n 
1 233 HIS n 
1 234 TRP n 
1 235 PHE n 
1 236 SER n 
1 237 ARG n 
1 238 GLU n 
1 239 ASN n 
1 240 SER n 
1 241 LEU n 
1 242 SER n 
1 243 GLY n 
1 244 VAL n 
1 245 GLU n 
1 246 GLY n 
1 247 GLU n 
1 248 GLY n 
1 249 LEU n 
1 250 HIS n 
1 251 LYS n 
1 252 LEU n 
1 253 GLY n 
1 254 TYR n 
1 255 ILE n 
1 256 LEU n 
1 257 ARG n 
1 258 ASP n 
1 259 VAL n 
1 260 SER n 
1 261 LYS n 
1 262 LYS n 
1 263 GLU n 
1 264 GLY n 
1 265 GLY n 
1 266 ALA n 
1 267 MET n 
1 268 TYR n 
1 269 ALA n 
1 270 ASP n 
1 271 ASP n 
1 272 THR n 
1 273 ALA n 
1 274 GLY n 
1 275 TRP n 
1 276 ASP n 
1 277 THR n 
1 278 ARG n 
1 279 ILE n 
1 280 THR n 
1 281 LEU n 
1 282 GLU n 
1 283 ASP n 
1 284 LEU n 
1 285 LYS n 
1 286 ASN n 
1 287 GLU n 
1 288 GLU n 
1 289 MET n 
1 290 VAL n 
1 291 THR n 
1 292 ASN n 
1 293 HIS n 
1 294 MET n 
1 295 GLU n 
1 296 GLY n 
1 297 GLU n 
1 298 HIS n 
1 299 LYS n 
1 300 LYS n 
1 301 LEU n 
1 302 ALA n 
1 303 GLU n 
1 304 ALA n 
1 305 ILE n 
1 306 PHE n 
1 307 LYS n 
1 308 LEU n 
1 309 THR n 
1 310 TYR n 
1 311 GLN n 
1 312 ASN n 
1 313 LYS n 
1 314 VAL n 
1 315 VAL n 
1 316 ARG n 
1 317 VAL n 
1 318 GLN n 
1 319 ARG n 
1 320 PRO n 
1 321 THR n 
1 322 PRO n 
1 323 ARG n 
1 324 GLY n 
1 325 THR n 
1 326 VAL n 
1 327 MET n 
1 328 ASP n 
1 329 ILE n 
1 330 ILE n 
1 331 SER n 
1 332 ARG n 
1 333 ARG n 
1 334 ASP n 
1 335 GLN n 
1 336 ARG n 
1 337 GLY n 
1 338 SER n 
1 339 GLY n 
1 340 GLN n 
1 341 VAL n 
1 342 VAL n 
1 343 THR n 
1 344 TYR n 
1 345 GLY n 
1 346 LEU n 
1 347 ASN n 
1 348 THR n 
1 349 PHE n 
1 350 THR n 
1 351 ASN n 
1 352 MET n 
1 353 GLU n 
1 354 ALA n 
1 355 GLN n 
1 356 LEU n 
1 357 ILE n 
1 358 ARG n 
1 359 GLN n 
1 360 MET n 
1 361 GLU n 
1 362 GLY n 
1 363 GLU n 
1 364 GLY n 
1 365 VAL n 
1 366 PHE n 
1 367 LYS n 
1 368 SER n 
1 369 ILE n 
1 370 GLN n 
1 371 HIS n 
1 372 LEU n 
1 373 THR n 
1 374 VAL n 
1 375 THR n 
1 376 GLU n 
1 377 GLU n 
1 378 ILE n 
1 379 ALA n 
1 380 VAL n 
1 381 LYS n 
1 382 ASN n 
1 383 TRP n 
1 384 LEU n 
1 385 VAL n 
1 386 ARG n 
1 387 VAL n 
1 388 GLY n 
1 389 ARG n 
1 390 GLU n 
1 391 ARG n 
1 392 LEU n 
1 393 SER n 
1 394 ARG n 
1 395 MET n 
1 396 ALA n 
1 397 ILE n 
1 398 SER n 
1 399 GLY n 
1 400 ASP n 
1 401 ASP n 
1 402 CYS n 
1 403 VAL n 
1 404 VAL n 
1 405 LYS n 
1 406 PRO n 
1 407 LEU n 
1 408 ASP n 
1 409 ASP n 
1 410 ARG n 
1 411 PHE n 
1 412 ALA n 
1 413 SER n 
1 414 ALA n 
1 415 LEU n 
1 416 THR n 
1 417 ALA n 
1 418 LEU n 
1 419 ASN n 
1 420 ASP n 
1 421 MET n 
1 422 GLY n 
1 423 LYS n 
1 424 VAL n 
1 425 ARG n 
1 426 LYS n 
1 427 ASP n 
1 428 ILE n 
1 429 GLN n 
1 430 GLN n 
1 431 TRP n 
1 432 GLU n 
1 433 PRO n 
1 434 SER n 
1 435 ARG n 
1 436 GLY n 
1 437 TRP n 
1 438 ASN n 
1 439 ASP n 
1 440 TRP n 
1 441 THR n 
1 442 GLN n 
1 443 VAL n 
1 444 PRO n 
1 445 PHE n 
1 446 CYS n 
1 447 SER n 
1 448 HIS n 
1 449 HIS n 
1 450 PHE n 
1 451 HIS n 
1 452 GLU n 
1 453 LEU n 
1 454 ILE n 
1 455 MET n 
1 456 LYS n 
1 457 ASP n 
1 458 GLY n 
1 459 ARG n 
1 460 VAL n 
1 461 LEU n 
1 462 VAL n 
1 463 VAL n 
1 464 PRO n 
1 465 CYS n 
1 466 ARG n 
1 467 ASN n 
1 468 GLN n 
1 469 ASP n 
1 470 GLU n 
1 471 LEU n 
1 472 ILE n 
1 473 GLY n 
1 474 ARG n 
1 475 ALA n 
1 476 ARG n 
1 477 ILE n 
1 478 SER n 
1 479 GLN n 
1 480 GLY n 
1 481 ALA n 
1 482 GLY n 
1 483 TRP n 
1 484 SER n 
1 485 LEU n 
1 486 ARG n 
1 487 GLU n 
1 488 THR n 
1 489 ALA n 
1 490 CYS n 
1 491 LEU n 
1 492 GLY n 
1 493 LYS n 
1 494 SER n 
1 495 TYR n 
1 496 ALA n 
1 497 GLN n 
1 498 MET n 
1 499 TRP n 
1 500 SER n 
1 501 LEU n 
1 502 MET n 
1 503 TYR n 
1 504 PHE n 
1 505 HIS n 
1 506 ARG n 
1 507 ARG n 
1 508 ASP n 
1 509 LEU n 
1 510 ARG n 
1 511 LEU n 
1 512 ALA n 
1 513 ALA n 
1 514 ASN n 
1 515 ALA n 
1 516 ILE n 
1 517 CYS n 
1 518 SER n 
1 519 ALA n 
1 520 VAL n 
1 521 PRO n 
1 522 SER n 
1 523 HIS n 
1 524 TRP n 
1 525 VAL n 
1 526 PRO n 
1 527 THR n 
1 528 SER n 
1 529 ARG n 
1 530 THR n 
1 531 THR n 
1 532 TRP n 
1 533 SER n 
1 534 ILE n 
1 535 HIS n 
1 536 ALA n 
1 537 THR n 
1 538 HIS n 
1 539 GLU n 
1 540 TRP n 
1 541 MET n 
1 542 THR n 
1 543 THR n 
1 544 GLU n 
1 545 ASP n 
1 546 MET n 
1 547 LEU n 
1 548 THR n 
1 549 VAL n 
1 550 TRP n 
1 551 ASN n 
1 552 ARG n 
1 553 VAL n 
1 554 TRP n 
1 555 ILE n 
1 556 GLN n 
1 557 GLU n 
1 558 ASN n 
1 559 PRO n 
1 560 TRP n 
1 561 MET n 
1 562 GLU n 
1 563 ASP n 
1 564 LYS n 
1 565 THR n 
1 566 PRO n 
1 567 VAL n 
1 568 GLU n 
1 569 SER n 
1 570 TRP n 
1 571 GLU n 
1 572 GLU n 
1 573 ILE n 
1 574 PRO n 
1 575 TYR n 
1 576 LEU n 
1 577 GLY n 
1 578 LYS n 
1 579 ARG n 
1 580 GLU n 
1 581 ASP n 
1 582 GLN n 
1 583 TRP n 
1 584 CYS n 
1 585 GLY n 
1 586 SER n 
1 587 LEU n 
1 588 ILE n 
1 589 GLY n 
1 590 LEU n 
1 591 THR n 
1 592 SER n 
1 593 ARG n 
1 594 ALA n 
1 595 THR n 
1 596 TRP n 
1 597 ALA n 
1 598 LYS n 
1 599 ASN n 
1 600 ILE n 
1 601 GLN n 
1 602 THR n 
1 603 ALA n 
1 604 ILE n 
1 605 ASN n 
1 606 GLN n 
1 607 VAL n 
1 608 ARG n 
1 609 SER n 
1 610 LEU n 
1 611 ILE n 
1 612 GLY n 
1 613 ASN n 
1 614 GLU n 
1 615 GLU n 
1 616 TYR n 
1 617 THR n 
1 618 ASP n 
1 619 TYR n 
1 620 MET n 
1 621 PRO n 
1 622 SER n 
1 623 MET n 
1 624 LYS n 
1 625 ARG n 
1 626 PHE n 
1 627 ARG n 
1 628 ARG n 
1 629 GLU n 
1 630 GLU n 
1 631 GLU n 
1 632 GLU n 
1 633 ALA n 
1 634 GLY n 
1 635 VAL n 
1 636 LEU n 
1 637 TRP n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   637 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'dengue virus type 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     11060 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1BZP non-polymer         . '3-fluoro-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzene-1-sulfonamide' ? 'C12 H14 F N3 O2 S' 283.322 
ALA   'L-peptide linking' y ALANINE                                                             ? 'C3 H7 N O2'        89.093  
ARG   'L-peptide linking' y ARGININE                                                            ? 'C6 H15 N4 O2 1'    175.209 
ASN   'L-peptide linking' y ASPARAGINE                                                          ? 'C4 H8 N2 O3'       132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID'                                                     ? 'C4 H7 N O4'        133.103 
CL    non-polymer         . 'CHLORIDE ION'                                                      ? 'Cl -1'             35.453  
CYS   'L-peptide linking' y CYSTEINE                                                            ? 'C3 H7 N O2 S'      121.158 
DMS   non-polymer         . 'DIMETHYL SULFOXIDE'                                                ? 'C2 H6 O S'         78.133  
GLN   'L-peptide linking' y GLUTAMINE                                                           ? 'C5 H10 N2 O3'      146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID'                                                     ? 'C5 H9 N O4'        147.129 
GLY   'peptide linking'   y GLYCINE                                                             ? 'C2 H5 N O2'        75.067  
HIS   'L-peptide linking' y HISTIDINE                                                           ? 'C6 H10 N3 O2 1'    156.162 
HOH   non-polymer         . WATER                                                               ? 'H2 O'              18.015  
ILE   'L-peptide linking' y ISOLEUCINE                                                          ? 'C6 H13 N O2'       131.173 
LEU   'L-peptide linking' y LEUCINE                                                             ? 'C6 H13 N O2'       131.173 
LYS   'L-peptide linking' y LYSINE                                                              ? 'C6 H15 N2 O2 1'    147.195 
MES   non-polymer         . '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'                              ? 'C6 H13 N O4 S'     195.237 
MET   'L-peptide linking' y METHIONINE                                                          ? 'C5 H11 N O2 S'     149.211 
PEG   non-polymer         . 'DI(HYDROXYETHYL)ETHER'                                             ? 'C4 H10 O3'         106.120 
PHE   'L-peptide linking' y PHENYLALANINE                                                       ? 'C9 H11 N O2'       165.189 
PO4   non-polymer         . 'PHOSPHATE ION'                                                     ? 'O4 P -3'           94.971  
PRO   'L-peptide linking' y PROLINE                                                             ? 'C5 H9 N O2'        115.130 
SER   'L-peptide linking' y SERINE                                                              ? 'C3 H7 N O3'        105.093 
THR   'L-peptide linking' y THREONINE                                                           ? 'C4 H9 N O3'        119.119 
TRP   'L-peptide linking' y TRYPTOPHAN                                                          ? 'C11 H12 N2 O2'     204.225 
TYR   'L-peptide linking' y TYROSINE                                                            ? 'C9 H11 N O3'       181.189 
VAL   'L-peptide linking' y VALINE                                                              ? 'C5 H11 N O2'       117.146 
ZN    non-polymer         . 'ZINC ION'                                                          ? 'Zn 2'              65.409  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   264 ?   ?   ?   A . n 
A 1 2   PRO 2   265 ?   ?   ?   A . n 
A 1 3   GLY 3   266 ?   ?   ?   A . n 
A 1 4   ILE 4   267 ?   ?   ?   A . n 
A 1 5   GLU 5   268 ?   ?   ?   A . n 
A 1 6   SER 6   269 ?   ?   ?   A . n 
A 1 7   GLU 7   270 ?   ?   ?   A . n 
A 1 8   THR 8   271 ?   ?   ?   A . n 
A 1 9   PRO 9   272 ?   ?   ?   A . n 
A 1 10  ASN 10  273 273 ASN ASN A . n 
A 1 11  LEU 11  274 274 LEU LEU A . n 
A 1 12  ASP 12  275 275 ASP ASP A . n 
A 1 13  ILE 13  276 276 ILE ILE A . n 
A 1 14  ILE 14  277 277 ILE ILE A . n 
A 1 15  GLY 15  278 278 GLY GLY A . n 
A 1 16  LYS 16  279 279 LYS LYS A . n 
A 1 17  ARG 17  280 280 ARG ARG A . n 
A 1 18  ILE 18  281 281 ILE ILE A . n 
A 1 19  GLU 19  282 282 GLU GLU A . n 
A 1 20  LYS 20  283 283 LYS LYS A . n 
A 1 21  ILE 21  284 284 ILE ILE A . n 
A 1 22  LYS 22  285 285 LYS LYS A . n 
A 1 23  GLN 23  286 286 GLN GLN A . n 
A 1 24  GLU 24  287 287 GLU GLU A . n 
A 1 25  HIS 25  288 288 HIS HIS A . n 
A 1 26  GLU 26  289 289 GLU GLU A . n 
A 1 27  THR 27  290 290 THR THR A . n 
A 1 28  SER 28  291 291 SER SER A . n 
A 1 29  TRP 29  292 292 TRP TRP A . n 
A 1 30  HIS 30  293 293 HIS HIS A . n 
A 1 31  TYR 31  294 294 TYR TYR A . n 
A 1 32  ASP 32  295 295 ASP ASP A . n 
A 1 33  GLN 33  296 296 GLN GLN A . n 
A 1 34  ASP 34  297 297 ASP ASP A . n 
A 1 35  HIS 35  298 298 HIS HIS A . n 
A 1 36  PRO 36  299 299 PRO PRO A . n 
A 1 37  TYR 37  300 300 TYR TYR A . n 
A 1 38  LYS 38  301 301 LYS LYS A . n 
A 1 39  THR 39  302 302 THR THR A . n 
A 1 40  TRP 40  303 303 TRP TRP A . n 
A 1 41  ALA 41  304 304 ALA ALA A . n 
A 1 42  TYR 42  305 305 TYR TYR A . n 
A 1 43  HIS 43  306 306 HIS HIS A . n 
A 1 44  GLY 44  307 307 GLY GLY A . n 
A 1 45  SER 45  308 308 SER SER A . n 
A 1 46  TYR 46  309 309 TYR TYR A . n 
A 1 47  GLU 47  310 310 GLU GLU A . n 
A 1 48  THR 48  311 311 THR THR A . n 
A 1 49  LYS 49  312 ?   ?   ?   A . n 
A 1 50  GLN 50  313 ?   ?   ?   A . n 
A 1 51  THR 51  314 ?   ?   ?   A . n 
A 1 52  GLY 52  315 ?   ?   ?   A . n 
A 1 53  SER 53  316 ?   ?   ?   A . n 
A 1 54  ALA 54  317 ?   ?   ?   A . n 
A 1 55  SER 55  318 318 SER SER A . n 
A 1 56  SER 56  319 319 SER SER A . n 
A 1 57  MET 57  320 320 MET MET A . n 
A 1 58  VAL 58  321 321 VAL VAL A . n 
A 1 59  ASN 59  322 322 ASN ASN A . n 
A 1 60  GLY 60  323 323 GLY GLY A . n 
A 1 61  VAL 61  324 324 VAL VAL A . n 
A 1 62  VAL 62  325 325 VAL VAL A . n 
A 1 63  ARG 63  326 326 ARG ARG A . n 
A 1 64  LEU 64  327 327 LEU LEU A . n 
A 1 65  LEU 65  328 328 LEU LEU A . n 
A 1 66  THR 66  329 329 THR THR A . n 
A 1 67  LYS 67  330 330 LYS LYS A . n 
A 1 68  PRO 68  331 331 PRO PRO A . n 
A 1 69  TRP 69  332 332 TRP TRP A . n 
A 1 70  ASP 70  333 333 ASP ASP A . n 
A 1 71  ILE 71  334 334 ILE ILE A . n 
A 1 72  ILE 72  335 335 ILE ILE A . n 
A 1 73  PRO 73  336 336 PRO PRO A . n 
A 1 74  MET 74  337 337 MET MET A . n 
A 1 75  VAL 75  338 338 VAL VAL A . n 
A 1 76  THR 76  339 339 THR THR A . n 
A 1 77  GLN 77  340 340 GLN GLN A . n 
A 1 78  MET 78  341 341 MET MET A . n 
A 1 79  ALA 79  342 342 ALA ALA A . n 
A 1 80  MET 80  343 343 MET MET A . n 
A 1 81  THR 81  344 344 THR GLY A . n 
A 1 82  ASP 82  345 ?   ?   ?   A . n 
A 1 83  THR 83  346 ?   ?   ?   A . n 
A 1 84  THR 84  347 ?   ?   ?   A . n 
A 1 85  PRO 85  348 ?   ?   ?   A . n 
A 1 86  PHE 86  349 ?   ?   ?   A . n 
A 1 87  GLY 87  350 ?   ?   ?   A . n 
A 1 88  GLN 88  351 ?   ?   ?   A . n 
A 1 89  GLN 89  352 ?   ?   ?   A . n 
A 1 90  ARG 90  353 ?   ?   ?   A . n 
A 1 91  VAL 91  354 ?   ?   ?   A . n 
A 1 92  PHE 92  355 ?   ?   ?   A . n 
A 1 93  LYS 93  356 356 LYS LYS A . n 
A 1 94  GLU 94  357 357 GLU GLU A . n 
A 1 95  LYS 95  358 358 LYS LYS A . n 
A 1 96  VAL 96  359 359 VAL VAL A . n 
A 1 97  ASP 97  360 360 ASP ASP A . n 
A 1 98  THR 98  361 361 THR THR A . n 
A 1 99  ARG 99  362 362 ARG ARG A . n 
A 1 100 THR 100 363 363 THR THR A . n 
A 1 101 GLN 101 364 364 GLN GLN A . n 
A 1 102 GLU 102 365 365 GLU GLU A . n 
A 1 103 PRO 103 366 366 PRO PRO A . n 
A 1 104 LYS 104 367 367 LYS LYS A . n 
A 1 105 GLU 105 368 368 GLU GLU A . n 
A 1 106 GLY 106 369 369 GLY GLY A . n 
A 1 107 THR 107 370 370 THR THR A . n 
A 1 108 LYS 108 371 371 LYS LYS A . n 
A 1 109 LYS 109 372 372 LYS LYS A . n 
A 1 110 LEU 110 373 373 LEU LEU A . n 
A 1 111 MET 111 374 374 MET MET A . n 
A 1 112 LYS 112 375 375 LYS LYS A . n 
A 1 113 ILE 113 376 376 ILE ILE A . n 
A 1 114 THR 114 377 377 THR THR A . n 
A 1 115 ALA 115 378 378 ALA ALA A . n 
A 1 116 GLU 116 379 379 GLU GLU A . n 
A 1 117 TRP 117 380 380 TRP TRP A . n 
A 1 118 LEU 118 381 381 LEU LEU A . n 
A 1 119 TRP 119 382 382 TRP TRP A . n 
A 1 120 LYS 120 383 383 LYS LYS A . n 
A 1 121 GLU 121 384 384 GLU GLU A . n 
A 1 122 LEU 122 385 385 LEU LEU A . n 
A 1 123 GLY 123 386 386 GLY GLY A . n 
A 1 124 LYS 124 387 387 LYS LYS A . n 
A 1 125 LYS 125 388 388 LYS LYS A . n 
A 1 126 LYS 126 389 389 LYS LYS A . n 
A 1 127 THR 127 390 390 THR THR A . n 
A 1 128 PRO 128 391 391 PRO PRO A . n 
A 1 129 ARG 129 392 392 ARG ARG A . n 
A 1 130 MET 130 393 393 MET MET A . n 
A 1 131 CYS 131 394 394 CYS CYS A . n 
A 1 132 THR 132 395 395 THR THR A . n 
A 1 133 ARG 133 396 396 ARG ARG A . n 
A 1 134 GLU 134 397 397 GLU GLU A . n 
A 1 135 GLU 135 398 398 GLU GLU A . n 
A 1 136 PHE 136 399 399 PHE PHE A . n 
A 1 137 THR 137 400 400 THR THR A . n 
A 1 138 ARG 138 401 401 ARG ARG A . n 
A 1 139 LYS 139 402 402 LYS LYS A . n 
A 1 140 VAL 140 403 403 VAL VAL A . n 
A 1 141 ARG 141 404 404 ARG ARG A . n 
A 1 142 SER 142 405 405 SER SER A . n 
A 1 143 ASN 143 406 406 ASN ASN A . n 
A 1 144 ALA 144 407 407 ALA ALA A . n 
A 1 145 ALA 145 408 408 ALA ALA A . n 
A 1 146 LEU 146 409 409 LEU LEU A . n 
A 1 147 GLY 147 410 410 GLY GLY A . n 
A 1 148 ALA 148 411 411 ALA ALA A . n 
A 1 149 ILE 149 412 412 ILE ILE A . n 
A 1 150 PHE 150 413 ?   ?   ?   A . n 
A 1 151 THR 151 414 ?   ?   ?   A . n 
A 1 152 ASP 152 415 ?   ?   ?   A . n 
A 1 153 GLU 153 416 ?   ?   ?   A . n 
A 1 154 ASN 154 417 ?   ?   ?   A . n 
A 1 155 LYS 155 418 418 LYS LYS A . n 
A 1 156 TRP 156 419 419 TRP TRP A . n 
A 1 157 LYS 157 420 420 LYS LYS A . n 
A 1 158 SER 158 421 421 SER SER A . n 
A 1 159 ALA 159 422 422 ALA ALA A . n 
A 1 160 ARG 160 423 423 ARG ARG A . n 
A 1 161 GLU 161 424 424 GLU GLU A . n 
A 1 162 ALA 162 425 425 ALA ALA A . n 
A 1 163 VAL 163 426 426 VAL VAL A . n 
A 1 164 GLU 164 427 427 GLU GLU A . n 
A 1 165 ASP 165 428 428 ASP ASP A . n 
A 1 166 SER 166 429 429 SER SER A . n 
A 1 167 GLY 167 430 430 GLY GLY A . n 
A 1 168 PHE 168 431 431 PHE PHE A . n 
A 1 169 TRP 169 432 432 TRP TRP A . n 
A 1 170 GLU 170 433 433 GLU GLU A . n 
A 1 171 LEU 171 434 434 LEU LEU A . n 
A 1 172 VAL 172 435 435 VAL VAL A . n 
A 1 173 ASP 173 436 436 ASP ASP A . n 
A 1 174 LYS 174 437 437 LYS LYS A . n 
A 1 175 GLU 175 438 438 GLU GLU A . n 
A 1 176 ARG 176 439 439 ARG ARG A . n 
A 1 177 ASN 177 440 440 ASN ASN A . n 
A 1 178 LEU 178 441 441 LEU LEU A . n 
A 1 179 HIS 179 442 442 HIS HIS A . n 
A 1 180 LEU 180 443 443 LEU LEU A . n 
A 1 181 GLU 181 444 444 GLU GLU A . n 
A 1 182 GLY 182 445 445 GLY GLY A . n 
A 1 183 LYS 183 446 446 LYS LYS A . n 
A 1 184 CYS 184 447 447 CYS CYS A . n 
A 1 185 GLU 185 448 448 GLU GLU A . n 
A 1 186 THR 186 449 449 THR THR A . n 
A 1 187 CYS 187 450 450 CYS CYS A . n 
A 1 188 VAL 188 451 451 VAL VAL A . n 
A 1 189 TYR 189 452 452 TYR TYR A . n 
A 1 190 ASN 190 453 453 ASN ASN A . n 
A 1 191 MET 191 454 454 MET MET A . n 
A 1 192 MET 192 455 455 MET MET A . n 
A 1 193 GLY 193 456 ?   ?   ?   A . n 
A 1 194 LYS 194 457 ?   ?   ?   A . n 
A 1 195 ARG 195 458 ?   ?   ?   A . n 
A 1 196 GLU 196 459 ?   ?   ?   A . n 
A 1 197 LYS 197 460 ?   ?   ?   A . n 
A 1 198 LYS 198 461 ?   ?   ?   A . n 
A 1 199 LEU 199 462 ?   ?   ?   A . n 
A 1 200 GLY 200 463 ?   ?   ?   A . n 
A 1 201 GLU 201 464 ?   ?   ?   A . n 
A 1 202 PHE 202 465 ?   ?   ?   A . n 
A 1 203 GLY 203 466 ?   ?   ?   A . n 
A 1 204 LYS 204 467 ?   ?   ?   A . n 
A 1 205 ALA 205 468 ?   ?   ?   A . n 
A 1 206 LYS 206 469 ?   ?   ?   A . n 
A 1 207 GLY 207 470 ?   ?   ?   A . n 
A 1 208 SER 208 471 ?   ?   ?   A . n 
A 1 209 ARG 209 472 ?   ?   ?   A . n 
A 1 210 ALA 210 473 473 ALA ALA A . n 
A 1 211 ILE 211 474 474 ILE ILE A . n 
A 1 212 TRP 212 475 475 TRP TRP A . n 
A 1 213 TYR 213 476 476 TYR TYR A . n 
A 1 214 MET 214 477 477 MET MET A . n 
A 1 215 TRP 215 478 478 TRP TRP A . n 
A 1 216 LEU 216 479 479 LEU LEU A . n 
A 1 217 GLY 217 480 480 GLY GLY A . n 
A 1 218 ALA 218 481 481 ALA ALA A . n 
A 1 219 ARG 219 482 482 ARG ARG A . n 
A 1 220 PHE 220 483 483 PHE PHE A . n 
A 1 221 LEU 221 484 484 LEU LEU A . n 
A 1 222 GLU 222 485 485 GLU GLU A . n 
A 1 223 PHE 223 486 486 PHE PHE A . n 
A 1 224 GLU 224 487 487 GLU GLU A . n 
A 1 225 ALA 225 488 488 ALA ALA A . n 
A 1 226 LEU 226 489 489 LEU LEU A . n 
A 1 227 GLY 227 490 490 GLY GLY A . n 
A 1 228 PHE 228 491 491 PHE PHE A . n 
A 1 229 LEU 229 492 492 LEU LEU A . n 
A 1 230 ASN 230 493 493 ASN ASN A . n 
A 1 231 GLU 231 494 494 GLU GLU A . n 
A 1 232 ASP 232 495 495 ASP ASP A . n 
A 1 233 HIS 233 496 496 HIS HIS A . n 
A 1 234 TRP 234 497 497 TRP TRP A . n 
A 1 235 PHE 235 498 498 PHE PHE A . n 
A 1 236 SER 236 499 499 SER SER A . n 
A 1 237 ARG 237 500 500 ARG ARG A . n 
A 1 238 GLU 238 501 501 GLU GLU A . n 
A 1 239 ASN 239 502 502 ASN ASN A . n 
A 1 240 SER 240 503 503 SER SER A . n 
A 1 241 LEU 241 504 504 LEU LEU A . n 
A 1 242 SER 242 505 505 SER SER A . n 
A 1 243 GLY 243 506 506 GLY GLY A . n 
A 1 244 VAL 244 507 507 VAL VAL A . n 
A 1 245 GLU 245 508 508 GLU GLU A . n 
A 1 246 GLY 246 509 509 GLY GLY A . n 
A 1 247 GLU 247 510 510 GLU GLU A . n 
A 1 248 GLY 248 511 511 GLY GLY A . n 
A 1 249 LEU 249 512 512 LEU LEU A . n 
A 1 250 HIS 250 513 513 HIS HIS A . n 
A 1 251 LYS 251 514 514 LYS LYS A . n 
A 1 252 LEU 252 515 515 LEU LEU A . n 
A 1 253 GLY 253 516 516 GLY GLY A . n 
A 1 254 TYR 254 517 517 TYR TYR A . n 
A 1 255 ILE 255 518 518 ILE ILE A . n 
A 1 256 LEU 256 519 519 LEU LEU A . n 
A 1 257 ARG 257 520 520 ARG ARG A . n 
A 1 258 ASP 258 521 521 ASP ASP A . n 
A 1 259 VAL 259 522 522 VAL VAL A . n 
A 1 260 SER 260 523 523 SER SER A . n 
A 1 261 LYS 261 524 524 LYS LYS A . n 
A 1 262 LYS 262 525 525 LYS LYS A . n 
A 1 263 GLU 263 526 526 GLU GLU A . n 
A 1 264 GLY 264 527 527 GLY GLY A . n 
A 1 265 GLY 265 528 528 GLY GLY A . n 
A 1 266 ALA 266 529 529 ALA ALA A . n 
A 1 267 MET 267 530 530 MET MET A . n 
A 1 268 TYR 268 531 531 TYR TYR A . n 
A 1 269 ALA 269 532 532 ALA ALA A . n 
A 1 270 ASP 270 533 533 ASP ASP A . n 
A 1 271 ASP 271 534 534 ASP ASP A . n 
A 1 272 THR 272 535 535 THR THR A . n 
A 1 273 ALA 273 536 536 ALA ALA A . n 
A 1 274 GLY 274 537 537 GLY GLY A . n 
A 1 275 TRP 275 538 538 TRP TRP A . n 
A 1 276 ASP 276 539 539 ASP ASP A . n 
A 1 277 THR 277 540 540 THR THR A . n 
A 1 278 ARG 278 541 541 ARG ARG A . n 
A 1 279 ILE 279 542 542 ILE ILE A . n 
A 1 280 THR 280 543 543 THR THR A . n 
A 1 281 LEU 281 544 544 LEU LEU A . n 
A 1 282 GLU 282 545 545 GLU GLU A . n 
A 1 283 ASP 283 546 546 ASP ASP A . n 
A 1 284 LEU 284 547 547 LEU LEU A . n 
A 1 285 LYS 285 548 548 LYS LYS A . n 
A 1 286 ASN 286 549 549 ASN ASN A . n 
A 1 287 GLU 287 550 550 GLU GLU A . n 
A 1 288 GLU 288 551 551 GLU GLU A . n 
A 1 289 MET 289 552 552 MET MET A . n 
A 1 290 VAL 290 553 553 VAL VAL A . n 
A 1 291 THR 291 554 554 THR THR A . n 
A 1 292 ASN 292 555 555 ASN ASN A . n 
A 1 293 HIS 293 556 556 HIS HIS A . n 
A 1 294 MET 294 557 557 MET MET A . n 
A 1 295 GLU 295 558 558 GLU GLU A . n 
A 1 296 GLY 296 559 559 GLY GLY A . n 
A 1 297 GLU 297 560 560 GLU GLU A . n 
A 1 298 HIS 298 561 561 HIS HIS A . n 
A 1 299 LYS 299 562 562 LYS LYS A . n 
A 1 300 LYS 300 563 563 LYS LYS A . n 
A 1 301 LEU 301 564 564 LEU LEU A . n 
A 1 302 ALA 302 565 565 ALA ALA A . n 
A 1 303 GLU 303 566 566 GLU GLU A . n 
A 1 304 ALA 304 567 567 ALA ALA A . n 
A 1 305 ILE 305 568 568 ILE ILE A . n 
A 1 306 PHE 306 569 569 PHE PHE A . n 
A 1 307 LYS 307 570 570 LYS LYS A . n 
A 1 308 LEU 308 571 571 LEU LEU A . n 
A 1 309 THR 309 572 572 THR THR A . n 
A 1 310 TYR 310 573 573 TYR TYR A . n 
A 1 311 GLN 311 574 574 GLN GLN A . n 
A 1 312 ASN 312 575 575 ASN ASN A . n 
A 1 313 LYS 313 576 576 LYS LYS A . n 
A 1 314 VAL 314 577 577 VAL VAL A . n 
A 1 315 VAL 315 578 578 VAL VAL A . n 
A 1 316 ARG 316 579 579 ARG ARG A . n 
A 1 317 VAL 317 580 580 VAL VAL A . n 
A 1 318 GLN 318 581 581 GLN GLN A . n 
A 1 319 ARG 319 582 582 ARG ARG A . n 
A 1 320 PRO 320 583 583 PRO PRO A . n 
A 1 321 THR 321 584 584 THR THR A . n 
A 1 322 PRO 322 585 ?   ?   ?   A . n 
A 1 323 ARG 323 586 ?   ?   ?   A . n 
A 1 324 GLY 324 587 ?   ?   ?   A . n 
A 1 325 THR 325 588 588 THR THR A . n 
A 1 326 VAL 326 589 589 VAL VAL A . n 
A 1 327 MET 327 590 590 MET MET A . n 
A 1 328 ASP 328 591 591 ASP ASP A . n 
A 1 329 ILE 329 592 592 ILE ILE A . n 
A 1 330 ILE 330 593 593 ILE ILE A . n 
A 1 331 SER 331 594 594 SER SER A . n 
A 1 332 ARG 332 595 595 ARG ARG A . n 
A 1 333 ARG 333 596 596 ARG ARG A . n 
A 1 334 ASP 334 597 597 ASP ASP A . n 
A 1 335 GLN 335 598 598 GLN GLN A . n 
A 1 336 ARG 336 599 599 ARG ARG A . n 
A 1 337 GLY 337 600 600 GLY GLY A . n 
A 1 338 SER 338 601 601 SER SER A . n 
A 1 339 GLY 339 602 602 GLY GLY A . n 
A 1 340 GLN 340 603 603 GLN GLN A . n 
A 1 341 VAL 341 604 604 VAL VAL A . n 
A 1 342 VAL 342 605 605 VAL VAL A . n 
A 1 343 THR 343 606 606 THR THR A . n 
A 1 344 TYR 344 607 607 TYR TYR A . n 
A 1 345 GLY 345 608 608 GLY GLY A . n 
A 1 346 LEU 346 609 609 LEU LEU A . n 
A 1 347 ASN 347 610 610 ASN ASN A . n 
A 1 348 THR 348 611 611 THR THR A . n 
A 1 349 PHE 349 612 612 PHE PHE A . n 
A 1 350 THR 350 613 613 THR THR A . n 
A 1 351 ASN 351 614 614 ASN ASN A . n 
A 1 352 MET 352 615 615 MET MET A . n 
A 1 353 GLU 353 616 616 GLU GLU A . n 
A 1 354 ALA 354 617 617 ALA ALA A . n 
A 1 355 GLN 355 618 618 GLN GLN A . n 
A 1 356 LEU 356 619 619 LEU LEU A . n 
A 1 357 ILE 357 620 620 ILE ILE A . n 
A 1 358 ARG 358 621 621 ARG ARG A . n 
A 1 359 GLN 359 622 622 GLN GLN A . n 
A 1 360 MET 360 623 623 MET MET A . n 
A 1 361 GLU 361 624 624 GLU GLU A . n 
A 1 362 GLY 362 625 625 GLY GLY A . n 
A 1 363 GLU 363 626 626 GLU GLU A . n 
A 1 364 GLY 364 627 627 GLY GLY A . n 
A 1 365 VAL 365 628 628 VAL VAL A . n 
A 1 366 PHE 366 629 629 PHE PHE A . n 
A 1 367 LYS 367 630 630 LYS LYS A . n 
A 1 368 SER 368 631 631 SER SER A . n 
A 1 369 ILE 369 632 632 ILE ILE A . n 
A 1 370 GLN 370 633 633 GLN GLN A . n 
A 1 371 HIS 371 634 634 HIS HIS A . n 
A 1 372 LEU 372 635 635 LEU LEU A . n 
A 1 373 THR 373 636 636 THR THR A . n 
A 1 374 VAL 374 637 637 VAL VAL A . n 
A 1 375 THR 375 638 638 THR THR A . n 
A 1 376 GLU 376 639 639 GLU GLU A . n 
A 1 377 GLU 377 640 640 GLU GLU A . n 
A 1 378 ILE 378 641 641 ILE ILE A . n 
A 1 379 ALA 379 642 642 ALA ALA A . n 
A 1 380 VAL 380 643 643 VAL VAL A . n 
A 1 381 LYS 381 644 644 LYS LYS A . n 
A 1 382 ASN 382 645 645 ASN ASN A . n 
A 1 383 TRP 383 646 646 TRP TRP A . n 
A 1 384 LEU 384 647 647 LEU LEU A . n 
A 1 385 VAL 385 648 648 VAL VAL A . n 
A 1 386 ARG 386 649 649 ARG ARG A . n 
A 1 387 VAL 387 650 650 VAL VAL A . n 
A 1 388 GLY 388 651 651 GLY GLY A . n 
A 1 389 ARG 389 652 652 ARG ARG A . n 
A 1 390 GLU 390 653 653 GLU GLU A . n 
A 1 391 ARG 391 654 654 ARG ARG A . n 
A 1 392 LEU 392 655 655 LEU LEU A . n 
A 1 393 SER 393 656 656 SER SER A . n 
A 1 394 ARG 394 657 657 ARG ARG A . n 
A 1 395 MET 395 658 658 MET MET A . n 
A 1 396 ALA 396 659 659 ALA ALA A . n 
A 1 397 ILE 397 660 660 ILE ILE A . n 
A 1 398 SER 398 661 661 SER SER A . n 
A 1 399 GLY 399 662 662 GLY GLY A . n 
A 1 400 ASP 400 663 663 ASP ASP A . n 
A 1 401 ASP 401 664 664 ASP ASP A . n 
A 1 402 CYS 402 665 665 CYS CYS A . n 
A 1 403 VAL 403 666 666 VAL VAL A . n 
A 1 404 VAL 404 667 667 VAL VAL A . n 
A 1 405 LYS 405 668 668 LYS LYS A . n 
A 1 406 PRO 406 669 669 PRO PRO A . n 
A 1 407 LEU 407 670 670 LEU LEU A . n 
A 1 408 ASP 408 671 671 ASP ASP A . n 
A 1 409 ASP 409 672 672 ASP ASP A . n 
A 1 410 ARG 410 673 673 ARG ARG A . n 
A 1 411 PHE 411 674 674 PHE PHE A . n 
A 1 412 ALA 412 675 675 ALA ALA A . n 
A 1 413 SER 413 676 676 SER SER A . n 
A 1 414 ALA 414 677 677 ALA ALA A . n 
A 1 415 LEU 415 678 678 LEU LEU A . n 
A 1 416 THR 416 679 679 THR THR A . n 
A 1 417 ALA 417 680 680 ALA ALA A . n 
A 1 418 LEU 418 681 681 LEU LEU A . n 
A 1 419 ASN 419 682 682 ASN ASN A . n 
A 1 420 ASP 420 683 683 ASP ASP A . n 
A 1 421 MET 421 684 684 MET MET A . n 
A 1 422 GLY 422 685 685 GLY GLY A . n 
A 1 423 LYS 423 686 686 LYS LYS A . n 
A 1 424 VAL 424 687 687 VAL VAL A . n 
A 1 425 ARG 425 688 688 ARG ARG A . n 
A 1 426 LYS 426 689 689 LYS LYS A . n 
A 1 427 ASP 427 690 690 ASP ASP A . n 
A 1 428 ILE 428 691 691 ILE ILE A . n 
A 1 429 GLN 429 692 692 GLN GLN A . n 
A 1 430 GLN 430 693 693 GLN GLN A . n 
A 1 431 TRP 431 694 694 TRP TRP A . n 
A 1 432 GLU 432 695 695 GLU GLU A . n 
A 1 433 PRO 433 696 696 PRO PRO A . n 
A 1 434 SER 434 697 697 SER SER A . n 
A 1 435 ARG 435 698 698 ARG ARG A . n 
A 1 436 GLY 436 699 699 GLY GLY A . n 
A 1 437 TRP 437 700 700 TRP TRP A . n 
A 1 438 ASN 438 701 701 ASN ASN A . n 
A 1 439 ASP 439 702 702 ASP ASP A . n 
A 1 440 TRP 440 703 703 TRP TRP A . n 
A 1 441 THR 441 704 704 THR THR A . n 
A 1 442 GLN 442 705 705 GLN GLN A . n 
A 1 443 VAL 443 706 706 VAL VAL A . n 
A 1 444 PRO 444 707 707 PRO PRO A . n 
A 1 445 PHE 445 708 708 PHE PHE A . n 
A 1 446 CYS 446 709 709 CYS CYS A . n 
A 1 447 SER 447 710 710 SER SER A . n 
A 1 448 HIS 448 711 711 HIS HIS A . n 
A 1 449 HIS 449 712 712 HIS HIS A . n 
A 1 450 PHE 450 713 713 PHE PHE A . n 
A 1 451 HIS 451 714 714 HIS HIS A . n 
A 1 452 GLU 452 715 715 GLU GLU A . n 
A 1 453 LEU 453 716 716 LEU LEU A . n 
A 1 454 ILE 454 717 717 ILE ILE A . n 
A 1 455 MET 455 718 718 MET MET A . n 
A 1 456 LYS 456 719 719 LYS LYS A . n 
A 1 457 ASP 457 720 720 ASP ASP A . n 
A 1 458 GLY 458 721 721 GLY GLY A . n 
A 1 459 ARG 459 722 722 ARG ARG A . n 
A 1 460 VAL 460 723 723 VAL VAL A . n 
A 1 461 LEU 461 724 724 LEU LEU A . n 
A 1 462 VAL 462 725 725 VAL VAL A . n 
A 1 463 VAL 463 726 726 VAL VAL A . n 
A 1 464 PRO 464 727 727 PRO PRO A . n 
A 1 465 CYS 465 728 728 CYS CYS A . n 
A 1 466 ARG 466 729 729 ARG ARG A . n 
A 1 467 ASN 467 730 730 ASN ASN A . n 
A 1 468 GLN 468 731 731 GLN GLN A . n 
A 1 469 ASP 469 732 732 ASP ASP A . n 
A 1 470 GLU 470 733 733 GLU GLU A . n 
A 1 471 LEU 471 734 734 LEU LEU A . n 
A 1 472 ILE 472 735 735 ILE ILE A . n 
A 1 473 GLY 473 736 736 GLY GLY A . n 
A 1 474 ARG 474 737 737 ARG ARG A . n 
A 1 475 ALA 475 738 738 ALA ALA A . n 
A 1 476 ARG 476 739 739 ARG ARG A . n 
A 1 477 ILE 477 740 740 ILE ILE A . n 
A 1 478 SER 478 741 741 SER SER A . n 
A 1 479 GLN 479 742 742 GLN GLN A . n 
A 1 480 GLY 480 743 743 GLY GLY A . n 
A 1 481 ALA 481 744 744 ALA ALA A . n 
A 1 482 GLY 482 745 745 GLY GLY A . n 
A 1 483 TRP 483 746 746 TRP TRP A . n 
A 1 484 SER 484 747 747 SER SER A . n 
A 1 485 LEU 485 748 748 LEU LEU A . n 
A 1 486 ARG 486 749 749 ARG ARG A . n 
A 1 487 GLU 487 750 750 GLU GLU A . n 
A 1 488 THR 488 751 751 THR THR A . n 
A 1 489 ALA 489 752 752 ALA ALA A . n 
A 1 490 CYS 490 753 753 CYS CYS A . n 
A 1 491 LEU 491 754 754 LEU LEU A . n 
A 1 492 GLY 492 755 755 GLY GLY A . n 
A 1 493 LYS 493 756 756 LYS LYS A . n 
A 1 494 SER 494 757 757 SER SER A . n 
A 1 495 TYR 495 758 758 TYR TYR A . n 
A 1 496 ALA 496 759 759 ALA ALA A . n 
A 1 497 GLN 497 760 760 GLN GLN A . n 
A 1 498 MET 498 761 761 MET MET A . n 
A 1 499 TRP 499 762 762 TRP TRP A . n 
A 1 500 SER 500 763 763 SER SER A . n 
A 1 501 LEU 501 764 764 LEU LEU A . n 
A 1 502 MET 502 765 765 MET MET A . n 
A 1 503 TYR 503 766 766 TYR TYR A . n 
A 1 504 PHE 504 767 767 PHE PHE A . n 
A 1 505 HIS 505 768 768 HIS HIS A . n 
A 1 506 ARG 506 769 769 ARG ARG A . n 
A 1 507 ARG 507 770 770 ARG ARG A . n 
A 1 508 ASP 508 771 771 ASP ASP A . n 
A 1 509 LEU 509 772 772 LEU LEU A . n 
A 1 510 ARG 510 773 773 ARG ARG A . n 
A 1 511 LEU 511 774 774 LEU LEU A . n 
A 1 512 ALA 512 775 775 ALA ALA A . n 
A 1 513 ALA 513 776 776 ALA ALA A . n 
A 1 514 ASN 514 777 777 ASN ASN A . n 
A 1 515 ALA 515 778 778 ALA ALA A . n 
A 1 516 ILE 516 779 779 ILE ILE A . n 
A 1 517 CYS 517 780 780 CYS CYS A . n 
A 1 518 SER 518 781 781 SER SER A . n 
A 1 519 ALA 519 782 782 ALA ALA A . n 
A 1 520 VAL 520 783 783 VAL VAL A . n 
A 1 521 PRO 521 784 784 PRO PRO A . n 
A 1 522 SER 522 785 785 SER SER A . n 
A 1 523 HIS 523 786 786 HIS HIS A . n 
A 1 524 TRP 524 787 787 TRP TRP A . n 
A 1 525 VAL 525 788 788 VAL VAL A . n 
A 1 526 PRO 526 789 789 PRO PRO A . n 
A 1 527 THR 527 790 790 THR THR A . n 
A 1 528 SER 528 791 791 SER SER A . n 
A 1 529 ARG 529 792 792 ARG ARG A . n 
A 1 530 THR 530 793 793 THR THR A . n 
A 1 531 THR 531 794 794 THR THR A . n 
A 1 532 TRP 532 795 ?   ?   ?   A . n 
A 1 533 SER 533 796 ?   ?   ?   A . n 
A 1 534 ILE 534 797 ?   ?   ?   A . n 
A 1 535 HIS 535 798 ?   ?   ?   A . n 
A 1 536 ALA 536 799 799 ALA ALA A . n 
A 1 537 THR 537 800 800 THR THR A . n 
A 1 538 HIS 538 801 801 HIS HIS A . n 
A 1 539 GLU 539 802 802 GLU GLU A . n 
A 1 540 TRP 540 803 803 TRP TRP A . n 
A 1 541 MET 541 804 804 MET MET A . n 
A 1 542 THR 542 805 805 THR THR A . n 
A 1 543 THR 543 806 806 THR THR A . n 
A 1 544 GLU 544 807 807 GLU GLU A . n 
A 1 545 ASP 545 808 808 ASP ASP A . n 
A 1 546 MET 546 809 809 MET MET A . n 
A 1 547 LEU 547 810 810 LEU LEU A . n 
A 1 548 THR 548 811 811 THR THR A . n 
A 1 549 VAL 549 812 812 VAL VAL A . n 
A 1 550 TRP 550 813 813 TRP TRP A . n 
A 1 551 ASN 551 814 814 ASN ASN A . n 
A 1 552 ARG 552 815 815 ARG ARG A . n 
A 1 553 VAL 553 816 816 VAL VAL A . n 
A 1 554 TRP 554 817 817 TRP TRP A . n 
A 1 555 ILE 555 818 818 ILE ILE A . n 
A 1 556 GLN 556 819 819 GLN GLN A . n 
A 1 557 GLU 557 820 820 GLU GLU A . n 
A 1 558 ASN 558 821 821 ASN ASN A . n 
A 1 559 PRO 559 822 822 PRO PRO A . n 
A 1 560 TRP 560 823 823 TRP TRP A . n 
A 1 561 MET 561 824 824 MET MET A . n 
A 1 562 GLU 562 825 825 GLU GLU A . n 
A 1 563 ASP 563 826 826 ASP ASP A . n 
A 1 564 LYS 564 827 827 LYS LYS A . n 
A 1 565 THR 565 828 828 THR THR A . n 
A 1 566 PRO 566 829 829 PRO PRO A . n 
A 1 567 VAL 567 830 830 VAL VAL A . n 
A 1 568 GLU 568 831 831 GLU GLU A . n 
A 1 569 SER 569 832 832 SER SER A . n 
A 1 570 TRP 570 833 833 TRP TRP A . n 
A 1 571 GLU 571 834 834 GLU GLU A . n 
A 1 572 GLU 572 835 835 GLU GLU A . n 
A 1 573 ILE 573 836 836 ILE ILE A . n 
A 1 574 PRO 574 837 837 PRO PRO A . n 
A 1 575 TYR 575 838 838 TYR TYR A . n 
A 1 576 LEU 576 839 839 LEU LEU A . n 
A 1 577 GLY 577 840 840 GLY GLY A . n 
A 1 578 LYS 578 841 841 LYS LYS A . n 
A 1 579 ARG 579 842 842 ARG ARG A . n 
A 1 580 GLU 580 843 843 GLU GLU A . n 
A 1 581 ASP 581 844 844 ASP ASP A . n 
A 1 582 GLN 582 845 845 GLN GLN A . n 
A 1 583 TRP 583 846 846 TRP TRP A . n 
A 1 584 CYS 584 847 847 CYS CYS A . n 
A 1 585 GLY 585 848 848 GLY GLY A . n 
A 1 586 SER 586 849 849 SER SER A . n 
A 1 587 LEU 587 850 850 LEU LEU A . n 
A 1 588 ILE 588 851 851 ILE ILE A . n 
A 1 589 GLY 589 852 852 GLY GLY A . n 
A 1 590 LEU 590 853 853 LEU LEU A . n 
A 1 591 THR 591 854 854 THR THR A . n 
A 1 592 SER 592 855 855 SER SER A . n 
A 1 593 ARG 593 856 856 ARG ARG A . n 
A 1 594 ALA 594 857 857 ALA ALA A . n 
A 1 595 THR 595 858 858 THR THR A . n 
A 1 596 TRP 596 859 859 TRP TRP A . n 
A 1 597 ALA 597 860 860 ALA ALA A . n 
A 1 598 LYS 598 861 861 LYS LYS A . n 
A 1 599 ASN 599 862 862 ASN ASN A . n 
A 1 600 ILE 600 863 863 ILE ILE A . n 
A 1 601 GLN 601 864 864 GLN GLN A . n 
A 1 602 THR 602 865 865 THR THR A . n 
A 1 603 ALA 603 866 866 ALA ALA A . n 
A 1 604 ILE 604 867 867 ILE ILE A . n 
A 1 605 ASN 605 868 868 ASN ASN A . n 
A 1 606 GLN 606 869 869 GLN GLN A . n 
A 1 607 VAL 607 870 870 VAL VAL A . n 
A 1 608 ARG 608 871 871 ARG ARG A . n 
A 1 609 SER 609 872 872 SER SER A . n 
A 1 610 LEU 610 873 873 LEU LEU A . n 
A 1 611 ILE 611 874 874 ILE ILE A . n 
A 1 612 GLY 612 875 875 GLY GLY A . n 
A 1 613 ASN 613 876 876 ASN ASN A . n 
A 1 614 GLU 614 877 877 GLU GLU A . n 
A 1 615 GLU 615 878 878 GLU GLU A . n 
A 1 616 TYR 616 879 879 TYR TYR A . n 
A 1 617 THR 617 880 880 THR THR A . n 
A 1 618 ASP 618 881 881 ASP ASP A . n 
A 1 619 TYR 619 882 882 TYR TYR A . n 
A 1 620 MET 620 883 883 MET MET A . n 
A 1 621 PRO 621 884 884 PRO PRO A . n 
A 1 622 SER 622 885 885 SER SER A . n 
A 1 623 MET 623 886 886 MET MET A . n 
A 1 624 LYS 624 887 887 LYS LYS A . n 
A 1 625 ARG 625 888 888 ARG ARG A . n 
A 1 626 PHE 626 889 889 PHE PHE A . n 
A 1 627 ARG 627 890 890 ARG ARG A . n 
A 1 628 ARG 628 891 891 ARG ARG A . n 
A 1 629 GLU 629 892 ?   ?   ?   A . n 
A 1 630 GLU 630 893 ?   ?   ?   A . n 
A 1 631 GLU 631 894 ?   ?   ?   A . n 
A 1 632 GLU 632 895 ?   ?   ?   A . n 
A 1 633 ALA 633 896 ?   ?   ?   A . n 
A 1 634 GLY 634 897 ?   ?   ?   A . n 
A 1 635 VAL 635 898 ?   ?   ?   A . n 
A 1 636 LEU 636 899 ?   ?   ?   A . n 
A 1 637 TRP 637 900 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A1BZP 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A1BZP 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 ZN    1   1001 1001 ZN    ZN  A . 
C 2 ZN    1   1002 1002 ZN    ZN  A . 
D 3 MES   1   1003 1004 MES   MES A . 
E 4 DMS   1   1004 1530 DMS   DMS A . 
F 4 DMS   1   1005 1601 DMS   DMS A . 
G 4 DMS   1   1006 1602 DMS   DMS A . 
H 5 PEG   1   1007 1603 PEG   PEG A . 
I 6 PO4   1   1008 1604 PO4   PO4 A . 
J 6 PO4   1   1009 1606 PO4   PO4 A . 
K 5 PEG   1   1010 1607 PEG   PEG A . 
L 7 A1BZP 1   1011 1707 A1BZP LIG A . 
M 8 CL    1   1012 1    CL    CL  A . 
N 9 HOH   1   1101 177  HOH   HOH A . 
N 9 HOH   2   1102 259  HOH   HOH A . 
N 9 HOH   3   1103 466  HOH   HOH A . 
N 9 HOH   4   1104 254  HOH   HOH A . 
N 9 HOH   5   1105 11   HOH   HOH A . 
N 9 HOH   6   1106 230  HOH   HOH A . 
N 9 HOH   7   1107 189  HOH   HOH A . 
N 9 HOH   8   1108 152  HOH   HOH A . 
N 9 HOH   9   1109 341  HOH   HOH A . 
N 9 HOH   10  1110 149  HOH   HOH A . 
N 9 HOH   11  1111 34   HOH   HOH A . 
N 9 HOH   12  1112 52   HOH   HOH A . 
N 9 HOH   13  1113 273  HOH   HOH A . 
N 9 HOH   14  1114 191  HOH   HOH A . 
N 9 HOH   15  1115 120  HOH   HOH A . 
N 9 HOH   16  1116 204  HOH   HOH A . 
N 9 HOH   17  1117 251  HOH   HOH A . 
N 9 HOH   18  1118 165  HOH   HOH A . 
N 9 HOH   19  1119 195  HOH   HOH A . 
N 9 HOH   20  1120 76   HOH   HOH A . 
N 9 HOH   21  1121 201  HOH   HOH A . 
N 9 HOH   22  1122 174  HOH   HOH A . 
N 9 HOH   23  1123 92   HOH   HOH A . 
N 9 HOH   24  1124 90   HOH   HOH A . 
N 9 HOH   25  1125 216  HOH   HOH A . 
N 9 HOH   26  1126 342  HOH   HOH A . 
N 9 HOH   27  1127 133  HOH   HOH A . 
N 9 HOH   28  1128 148  HOH   HOH A . 
N 9 HOH   29  1129 223  HOH   HOH A . 
N 9 HOH   30  1130 348  HOH   HOH A . 
N 9 HOH   31  1131 267  HOH   HOH A . 
N 9 HOH   32  1132 227  HOH   HOH A . 
N 9 HOH   33  1133 16   HOH   HOH A . 
N 9 HOH   34  1134 153  HOH   HOH A . 
N 9 HOH   35  1135 96   HOH   HOH A . 
N 9 HOH   36  1136 176  HOH   HOH A . 
N 9 HOH   37  1137 187  HOH   HOH A . 
N 9 HOH   38  1138 108  HOH   HOH A . 
N 9 HOH   39  1139 202  HOH   HOH A . 
N 9 HOH   40  1140 226  HOH   HOH A . 
N 9 HOH   41  1141 209  HOH   HOH A . 
N 9 HOH   42  1142 197  HOH   HOH A . 
N 9 HOH   43  1143 222  HOH   HOH A . 
N 9 HOH   44  1144 319  HOH   HOH A . 
N 9 HOH   45  1145 280  HOH   HOH A . 
N 9 HOH   46  1146 296  HOH   HOH A . 
N 9 HOH   47  1147 258  HOH   HOH A . 
N 9 HOH   48  1148 345  HOH   HOH A . 
N 9 HOH   49  1149 214  HOH   HOH A . 
N 9 HOH   50  1150 31   HOH   HOH A . 
N 9 HOH   51  1151 5    HOH   HOH A . 
N 9 HOH   52  1152 206  HOH   HOH A . 
N 9 HOH   53  1153 462  HOH   HOH A . 
N 9 HOH   54  1154 207  HOH   HOH A . 
N 9 HOH   55  1155 199  HOH   HOH A . 
N 9 HOH   56  1156 465  HOH   HOH A . 
N 9 HOH   57  1157 210  HOH   HOH A . 
N 9 HOH   58  1158 7    HOH   HOH A . 
N 9 HOH   59  1159 2    HOH   HOH A . 
N 9 HOH   60  1160 178  HOH   HOH A . 
N 9 HOH   61  1161 211  HOH   HOH A . 
N 9 HOH   62  1162 183  HOH   HOH A . 
N 9 HOH   63  1163 392  HOH   HOH A . 
N 9 HOH   64  1164 185  HOH   HOH A . 
N 9 HOH   65  1165 303  HOH   HOH A . 
N 9 HOH   66  1166 19   HOH   HOH A . 
N 9 HOH   67  1167 317  HOH   HOH A . 
N 9 HOH   68  1168 190  HOH   HOH A . 
N 9 HOH   69  1169 196  HOH   HOH A . 
N 9 HOH   70  1170 188  HOH   HOH A . 
N 9 HOH   71  1171 249  HOH   HOH A . 
N 9 HOH   72  1172 252  HOH   HOH A . 
N 9 HOH   73  1173 305  HOH   HOH A . 
N 9 HOH   74  1174 225  HOH   HOH A . 
N 9 HOH   75  1175 180  HOH   HOH A . 
N 9 HOH   76  1176 217  HOH   HOH A . 
N 9 HOH   77  1177 307  HOH   HOH A . 
N 9 HOH   78  1178 250  HOH   HOH A . 
N 9 HOH   79  1179 239  HOH   HOH A . 
N 9 HOH   80  1180 85   HOH   HOH A . 
N 9 HOH   81  1181 215  HOH   HOH A . 
N 9 HOH   82  1182 205  HOH   HOH A . 
N 9 HOH   83  1183 218  HOH   HOH A . 
N 9 HOH   84  1184 266  HOH   HOH A . 
N 9 HOH   85  1185 184  HOH   HOH A . 
N 9 HOH   86  1186 166  HOH   HOH A . 
N 9 HOH   87  1187 328  HOH   HOH A . 
N 9 HOH   88  1188 256  HOH   HOH A . 
N 9 HOH   89  1189 89   HOH   HOH A . 
N 9 HOH   90  1190 242  HOH   HOH A . 
N 9 HOH   91  1191 312  HOH   HOH A . 
N 9 HOH   92  1192 186  HOH   HOH A . 
N 9 HOH   93  1193 220  HOH   HOH A . 
N 9 HOH   94  1194 281  HOH   HOH A . 
N 9 HOH   95  1195 264  HOH   HOH A . 
N 9 HOH   96  1196 358  HOH   HOH A . 
N 9 HOH   97  1197 25   HOH   HOH A . 
N 9 HOH   98  1198 46   HOH   HOH A . 
N 9 HOH   99  1199 179  HOH   HOH A . 
N 9 HOH   100 1200 236  HOH   HOH A . 
N 9 HOH   101 1201 260  HOH   HOH A . 
N 9 HOH   102 1202 47   HOH   HOH A . 
N 9 HOH   103 1203 182  HOH   HOH A . 
N 9 HOH   104 1204 234  HOH   HOH A . 
N 9 HOH   105 1205 458  HOH   HOH A . 
N 9 HOH   106 1206 3    HOH   HOH A . 
N 9 HOH   107 1207 213  HOH   HOH A . 
N 9 HOH   108 1208 198  HOH   HOH A . 
N 9 HOH   109 1209 300  HOH   HOH A . 
N 9 HOH   110 1210 119  HOH   HOH A . 
N 9 HOH   111 1211 231  HOH   HOH A . 
N 9 HOH   112 1212 69   HOH   HOH A . 
N 9 HOH   113 1213 268  HOH   HOH A . 
N 9 HOH   114 1214 292  HOH   HOH A . 
N 9 HOH   115 1215 274  HOH   HOH A . 
N 9 HOH   116 1216 65   HOH   HOH A . 
N 9 HOH   117 1217 243  HOH   HOH A . 
N 9 HOH   118 1218 276  HOH   HOH A . 
N 9 HOH   119 1219 127  HOH   HOH A . 
N 9 HOH   120 1220 460  HOH   HOH A . 
N 9 HOH   121 1221 238  HOH   HOH A . 
N 9 HOH   122 1222 240  HOH   HOH A . 
N 9 HOH   123 1223 294  HOH   HOH A . 
N 9 HOH   124 1224 144  HOH   HOH A . 
N 9 HOH   125 1225 232  HOH   HOH A . 
N 9 HOH   126 1226 86   HOH   HOH A . 
N 9 HOH   127 1227 29   HOH   HOH A . 
N 9 HOH   128 1228 244  HOH   HOH A . 
N 9 HOH   129 1229 247  HOH   HOH A . 
N 9 HOH   130 1230 289  HOH   HOH A . 
N 9 HOH   131 1231 277  HOH   HOH A . 
N 9 HOH   132 1232 164  HOH   HOH A . 
N 9 HOH   133 1233 315  HOH   HOH A . 
N 9 HOH   134 1234 10   HOH   HOH A . 
N 9 HOH   135 1235 145  HOH   HOH A . 
N 9 HOH   136 1236 235  HOH   HOH A . 
N 9 HOH   137 1237 356  HOH   HOH A . 
N 9 HOH   138 1238 265  HOH   HOH A . 
N 9 HOH   139 1239 306  HOH   HOH A . 
N 9 HOH   140 1240 151  HOH   HOH A . 
N 9 HOH   141 1241 45   HOH   HOH A . 
N 9 HOH   142 1242 194  HOH   HOH A . 
N 9 HOH   143 1243 288  HOH   HOH A . 
N 9 HOH   144 1244 308  HOH   HOH A . 
N 9 HOH   145 1245 279  HOH   HOH A . 
N 9 HOH   146 1246 60   HOH   HOH A . 
N 9 HOH   147 1247 39   HOH   HOH A . 
N 9 HOH   148 1248 261  HOH   HOH A . 
N 9 HOH   149 1249 4    HOH   HOH A . 
N 9 HOH   150 1250 23   HOH   HOH A . 
N 9 HOH   151 1251 366  HOH   HOH A . 
N 9 HOH   152 1252 27   HOH   HOH A . 
N 9 HOH   153 1253 257  HOH   HOH A . 
N 9 HOH   154 1254 290  HOH   HOH A . 
N 9 HOH   155 1255 293  HOH   HOH A . 
N 9 HOH   156 1256 270  HOH   HOH A . 
N 9 HOH   157 1257 285  HOH   HOH A . 
N 9 HOH   158 1258 233  HOH   HOH A . 
N 9 HOH   159 1259 368  HOH   HOH A . 
N 9 HOH   160 1260 309  HOH   HOH A . 
N 9 HOH   161 1261 302  HOH   HOH A . 
N 9 HOH   162 1262 386  HOH   HOH A . 
N 9 HOH   163 1263 304  HOH   HOH A . 
N 9 HOH   164 1264 371  HOH   HOH A . 
N 9 HOH   165 1265 221  HOH   HOH A . 
N 9 HOH   166 1266 26   HOH   HOH A . 
N 9 HOH   167 1267 322  HOH   HOH A . 
N 9 HOH   168 1268 401  HOH   HOH A . 
N 9 HOH   169 1269 246  HOH   HOH A . 
N 9 HOH   170 1270 112  HOH   HOH A . 
N 9 HOH   171 1271 143  HOH   HOH A . 
N 9 HOH   172 1272 325  HOH   HOH A . 
N 9 HOH   173 1273 106  HOH   HOH A . 
N 9 HOH   174 1274 311  HOH   HOH A . 
N 9 HOH   175 1275 22   HOH   HOH A . 
N 9 HOH   176 1276 150  HOH   HOH A . 
N 9 HOH   177 1277 245  HOH   HOH A . 
N 9 HOH   178 1278 269  HOH   HOH A . 
N 9 HOH   179 1279 287  HOH   HOH A . 
N 9 HOH   180 1280 278  HOH   HOH A . 
N 9 HOH   181 1281 335  HOH   HOH A . 
N 9 HOH   182 1282 219  HOH   HOH A . 
N 9 HOH   183 1283 286  HOH   HOH A . 
N 9 HOH   184 1284 42   HOH   HOH A . 
N 9 HOH   185 1285 37   HOH   HOH A . 
N 9 HOH   186 1286 333  HOH   HOH A . 
N 9 HOH   187 1287 125  HOH   HOH A . 
N 9 HOH   188 1288 275  HOH   HOH A . 
N 9 HOH   189 1289 318  HOH   HOH A . 
N 9 HOH   190 1290 320  HOH   HOH A . 
N 9 HOH   191 1291 262  HOH   HOH A . 
N 9 HOH   192 1292 352  HOH   HOH A . 
N 9 HOH   193 1293 271  HOH   HOH A . 
N 9 HOH   194 1294 329  HOH   HOH A . 
N 9 HOH   195 1295 30   HOH   HOH A . 
N 9 HOH   196 1296 66   HOH   HOH A . 
N 9 HOH   197 1297 339  HOH   HOH A . 
N 9 HOH   198 1298 272  HOH   HOH A . 
N 9 HOH   199 1299 212  HOH   HOH A . 
N 9 HOH   200 1300 284  HOH   HOH A . 
N 9 HOH   201 1301 321  HOH   HOH A . 
N 9 HOH   202 1302 395  HOH   HOH A . 
N 9 HOH   203 1303 357  HOH   HOH A . 
N 9 HOH   204 1304 241  HOH   HOH A . 
N 9 HOH   205 1305 372  HOH   HOH A . 
N 9 HOH   206 1306 330  HOH   HOH A . 
N 9 HOH   207 1307 323  HOH   HOH A . 
N 9 HOH   208 1308 38   HOH   HOH A . 
N 9 HOH   209 1309 344  HOH   HOH A . 
N 9 HOH   210 1310 360  HOH   HOH A . 
N 9 HOH   211 1311 389  HOH   HOH A . 
N 9 HOH   212 1312 255  HOH   HOH A . 
N 9 HOH   213 1313 67   HOH   HOH A . 
N 9 HOH   214 1314 355  HOH   HOH A . 
N 9 HOH   215 1315 203  HOH   HOH A . 
N 9 HOH   216 1316 298  HOH   HOH A . 
N 9 HOH   217 1317 18   HOH   HOH A . 
N 9 HOH   218 1318 343  HOH   HOH A . 
N 9 HOH   219 1319 175  HOH   HOH A . 
N 9 HOH   220 1320 364  HOH   HOH A . 
N 9 HOH   221 1321 346  HOH   HOH A . 
N 9 HOH   222 1322 15   HOH   HOH A . 
N 9 HOH   223 1323 400  HOH   HOH A . 
N 9 HOH   224 1324 331  HOH   HOH A . 
N 9 HOH   225 1325 369  HOH   HOH A . 
N 9 HOH   226 1326 367  HOH   HOH A . 
N 9 HOH   227 1327 396  HOH   HOH A . 
N 9 HOH   228 1328 33   HOH   HOH A . 
N 9 HOH   229 1329 378  HOH   HOH A . 
N 9 HOH   230 1330 375  HOH   HOH A . 
N 9 HOH   231 1331 377  HOH   HOH A . 
N 9 HOH   232 1332 363  HOH   HOH A . 
N 9 HOH   233 1333 381  HOH   HOH A . 
N 9 HOH   234 1334 350  HOH   HOH A . 
N 9 HOH   235 1335 62   HOH   HOH A . 
N 9 HOH   236 1336 351  HOH   HOH A . 
N 9 HOH   237 1337 224  HOH   HOH A . 
N 9 HOH   238 1338 110  HOH   HOH A . 
N 9 HOH   239 1339 282  HOH   HOH A . 
N 9 HOH   240 1340 374  HOH   HOH A . 
N 9 HOH   241 1341 295  HOH   HOH A . 
N 9 HOH   242 1342 399  HOH   HOH A . 
N 9 HOH   243 1343 297  HOH   HOH A . 
N 9 HOH   244 1344 316  HOH   HOH A . 
N 9 HOH   245 1345 314  HOH   HOH A . 
N 9 HOH   246 1346 114  HOH   HOH A . 
N 9 HOH   247 1347 388  HOH   HOH A . 
N 9 HOH   248 1348 228  HOH   HOH A . 
N 9 HOH   249 1349 376  HOH   HOH A . 
N 9 HOH   250 1350 334  HOH   HOH A . 
N 9 HOH   251 1351 136  HOH   HOH A . 
N 9 HOH   252 1352 283  HOH   HOH A . 
N 9 HOH   253 1353 380  HOH   HOH A . 
N 9 HOH   254 1354 14   HOH   HOH A . 
N 9 HOH   255 1355 57   HOH   HOH A . 
N 9 HOH   256 1356 263  HOH   HOH A . 
N 9 HOH   257 1357 338  HOH   HOH A . 
N 9 HOH   258 1358 423  HOH   HOH A . 
N 9 HOH   259 1359 379  HOH   HOH A . 
N 9 HOH   260 1360 237  HOH   HOH A . 
N 9 HOH   261 1361 1    HOH   HOH A . 
N 9 HOH   262 1362 70   HOH   HOH A . 
N 9 HOH   263 1363 347  HOH   HOH A . 
N 9 HOH   264 1364 451  HOH   HOH A . 
N 9 HOH   265 1365 83   HOH   HOH A . 
N 9 HOH   266 1366 32   HOH   HOH A . 
N 9 HOH   267 1367 384  HOH   HOH A . 
N 9 HOH   268 1368 349  HOH   HOH A . 
N 9 HOH   269 1369 24   HOH   HOH A . 
N 9 HOH   270 1370 138  HOH   HOH A . 
N 9 HOH   271 1371 354  HOH   HOH A . 
N 9 HOH   272 1372 91   HOH   HOH A . 
N 9 HOH   273 1373 99   HOH   HOH A . 
N 9 HOH   274 1374 402  HOH   HOH A . 
N 9 HOH   275 1375 365  HOH   HOH A . 
N 9 HOH   276 1376 387  HOH   HOH A . 
N 9 HOH   277 1377 394  HOH   HOH A . 
N 9 HOH   278 1378 398  HOH   HOH A . 
N 9 HOH   279 1379 109  HOH   HOH A . 
N 9 HOH   280 1380 299  HOH   HOH A . 
N 9 HOH   281 1381 404  HOH   HOH A . 
N 9 HOH   282 1382 461  HOH   HOH A . 
N 9 HOH   283 1383 82   HOH   HOH A . 
N 9 HOH   284 1384 391  HOH   HOH A . 
N 9 HOH   285 1385 406  HOH   HOH A . 
N 9 HOH   286 1386 468  HOH   HOH A . 
N 9 HOH   287 1387 13   HOH   HOH A . 
N 9 HOH   288 1388 393  HOH   HOH A . 
N 9 HOH   289 1389 405  HOH   HOH A . 
N 9 HOH   290 1390 100  HOH   HOH A . 
N 9 HOH   291 1391 170  HOH   HOH A . 
N 9 HOH   292 1392 118  HOH   HOH A . 
N 9 HOH   293 1393 248  HOH   HOH A . 
N 9 HOH   294 1394 142  HOH   HOH A . 
N 9 HOH   295 1395 98   HOH   HOH A . 
N 9 HOH   296 1396 326  HOH   HOH A . 
N 9 HOH   297 1397 411  HOH   HOH A . 
N 9 HOH   298 1398 359  HOH   HOH A . 
N 9 HOH   299 1399 122  HOH   HOH A . 
N 9 HOH   300 1400 117  HOH   HOH A . 
N 9 HOH   301 1401 56   HOH   HOH A . 
N 9 HOH   302 1402 340  HOH   HOH A . 
N 9 HOH   303 1403 412  HOH   HOH A . 
N 9 HOH   304 1404 422  HOH   HOH A . 
N 9 HOH   305 1405 200  HOH   HOH A . 
N 9 HOH   306 1406 421  HOH   HOH A . 
N 9 HOH   307 1407 390  HOH   HOH A . 
N 9 HOH   308 1408 464  HOH   HOH A . 
N 9 HOH   309 1409 80   HOH   HOH A . 
N 9 HOH   310 1410 124  HOH   HOH A . 
N 9 HOH   311 1411 40   HOH   HOH A . 
N 9 HOH   312 1412 444  HOH   HOH A . 
N 9 HOH   313 1413 137  HOH   HOH A . 
N 9 HOH   314 1414 6    HOH   HOH A . 
N 9 HOH   315 1415 417  HOH   HOH A . 
N 9 HOH   316 1416 403  HOH   HOH A . 
N 9 HOH   317 1417 463  HOH   HOH A . 
N 9 HOH   318 1418 181  HOH   HOH A . 
N 9 HOH   319 1419 415  HOH   HOH A . 
N 9 HOH   320 1420 373  HOH   HOH A . 
N 9 HOH   321 1421 413  HOH   HOH A . 
N 9 HOH   322 1422 454  HOH   HOH A . 
N 9 HOH   323 1423 43   HOH   HOH A . 
N 9 HOH   324 1424 418  HOH   HOH A . 
N 9 HOH   325 1425 310  HOH   HOH A . 
N 9 HOH   326 1426 97   HOH   HOH A . 
N 9 HOH   327 1427 193  HOH   HOH A . 
N 9 HOH   328 1428 424  HOH   HOH A . 
N 9 HOH   329 1429 429  HOH   HOH A . 
N 9 HOH   330 1430 128  HOH   HOH A . 
N 9 HOH   331 1431 332  HOH   HOH A . 
N 9 HOH   332 1432 111  HOH   HOH A . 
N 9 HOH   333 1433 436  HOH   HOH A . 
N 9 HOH   334 1434 132  HOH   HOH A . 
N 9 HOH   335 1435 385  HOH   HOH A . 
N 9 HOH   336 1436 419  HOH   HOH A . 
N 9 HOH   337 1437 253  HOH   HOH A . 
N 9 HOH   338 1438 459  HOH   HOH A . 
N 9 HOH   339 1439 12   HOH   HOH A . 
N 9 HOH   340 1440 324  HOH   HOH A . 
N 9 HOH   341 1441 28   HOH   HOH A . 
N 9 HOH   342 1442 409  HOH   HOH A . 
N 9 HOH   343 1443 337  HOH   HOH A . 
N 9 HOH   344 1444 48   HOH   HOH A . 
N 9 HOH   345 1445 456  HOH   HOH A . 
N 9 HOH   346 1446 439  HOH   HOH A . 
N 9 HOH   347 1447 430  HOH   HOH A . 
N 9 HOH   348 1448 428  HOH   HOH A . 
N 9 HOH   349 1449 414  HOH   HOH A . 
N 9 HOH   350 1450 452  HOH   HOH A . 
N 9 HOH   351 1451 425  HOH   HOH A . 
N 9 HOH   352 1452 438  HOH   HOH A . 
N 9 HOH   353 1453 433  HOH   HOH A . 
N 9 HOH   354 1454 434  HOH   HOH A . 
N 9 HOH   355 1455 61   HOH   HOH A . 
N 9 HOH   356 1456 101  HOH   HOH A . 
N 9 HOH   357 1457 41   HOH   HOH A . 
N 9 HOH   358 1458 20   HOH   HOH A . 
N 9 HOH   359 1459 437  HOH   HOH A . 
N 9 HOH   360 1460 397  HOH   HOH A . 
N 9 HOH   361 1461 407  HOH   HOH A . 
N 9 HOH   362 1462 75   HOH   HOH A . 
N 9 HOH   363 1463 94   HOH   HOH A . 
N 9 HOH   364 1464 44   HOH   HOH A . 
N 9 HOH   365 1465 443  HOH   HOH A . 
N 9 HOH   366 1466 229  HOH   HOH A . 
N 9 HOH   367 1467 432  HOH   HOH A . 
N 9 HOH   368 1468 435  HOH   HOH A . 
N 9 HOH   369 1469 123  HOH   HOH A . 
N 9 HOH   370 1470 141  HOH   HOH A . 
N 9 HOH   371 1471 467  HOH   HOH A . 
N 9 HOH   372 1472 103  HOH   HOH A . 
N 9 HOH   373 1473 140  HOH   HOH A . 
N 9 HOH   374 1474 301  HOH   HOH A . 
N 9 HOH   375 1475 8    HOH   HOH A . 
N 9 HOH   376 1476 51   HOH   HOH A . 
N 9 HOH   377 1477 172  HOH   HOH A . 
N 9 HOH   378 1478 63   HOH   HOH A . 
N 9 HOH   379 1479 121  HOH   HOH A . 
N 9 HOH   380 1480 445  HOH   HOH A . 
N 9 HOH   381 1481 115  HOH   HOH A . 
N 9 HOH   382 1482 74   HOH   HOH A . 
N 9 HOH   383 1483 442  HOH   HOH A . 
N 9 HOH   384 1484 55   HOH   HOH A . 
N 9 HOH   385 1485 78   HOH   HOH A . 
N 9 HOH   386 1486 126  HOH   HOH A . 
N 9 HOH   387 1487 447  HOH   HOH A . 
N 9 HOH   388 1488 64   HOH   HOH A . 
N 9 HOH   389 1489 441  HOH   HOH A . 
N 9 HOH   390 1490 449  HOH   HOH A . 
N 9 HOH   391 1491 448  HOH   HOH A . 
N 9 HOH   392 1492 440  HOH   HOH A . 
N 9 HOH   393 1493 9    HOH   HOH A . 
N 9 HOH   394 1494 49   HOH   HOH A . 
N 9 HOH   395 1495 17   HOH   HOH A . 
N 9 HOH   396 1496 73   HOH   HOH A . 
N 9 HOH   397 1497 173  HOH   HOH A . 
N 9 HOH   398 1498 450  HOH   HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 A THR 344 ? CB  ? A THR 81 CB  
2 1 Y 1 A THR 344 ? OG1 ? A THR 81 OG1 
3 1 Y 1 A THR 344 ? CG2 ? A THR 81 CG2 
# 
loop_
_software.classification 
_software.name 
_software.version 
_software.citation_id 
_software.pdbx_ordinal 
refinement       REFMAC  5.8.0267 ? 1 
refinement       REFMAC5 .        ? 2 
'data scaling'   Aimless .        ? 3 
phasing          PHASER  .        ? 4 
'data reduction' XDS     .        ? 5 
# 
_cell.entry_id           7I2C 
_cell.length_a           82.637 
_cell.length_b           117.008 
_cell.length_c           149.100 
_cell.angle_alpha        90.00 
_cell.angle_beta         90.00 
_cell.angle_gamma        90.00 
_cell.Z_PDB              8 
_cell.pdbx_unique_axis   ? 
# 
_symmetry.entry_id                         7I2C 
_symmetry.space_group_name_H-M             'I 2 2 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                23 
# 
_exptl.entry_id          7I2C 
_exptl.method            'X-RAY DIFFRACTION' 
_exptl.crystals_number   1 
# 
_exptl_crystal.id                    1 
_exptl_crystal.density_meas          ? 
_exptl_crystal.density_Matthews      2.44 
_exptl_crystal.density_percent_sol   49.57 
_exptl_crystal.description           ? 
# 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.pH              6.5 
_exptl_crystal_grow.temp            293.15 
_exptl_crystal_grow.pdbx_details    '350 mM Magnesium chloride, 10% PEG 4000, 100 mM MES, pH 6.5' 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.pdbx_pH_range   ? 
# 
_diffrn.id                     1 
_diffrn.ambient_temp           100 
_diffrn.crystal_id             1 
_diffrn.ambient_temp_details   ? 
# 
_diffrn_detector.detector               PIXEL 
_diffrn_detector.type                   'DECTRIS EIGER2 XE 9M' 
_diffrn_detector.pdbx_collection_date   2023-08-09 
_diffrn_detector.diffrn_id              1 
_diffrn_detector.details                ? 
# 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.92124 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.diffrn_id                   1 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.type                        'DIAMOND BEAMLINE I04-1' 
_diffrn_source.pdbx_wavelength_list        0.92124 
_diffrn_source.pdbx_synchrotron_site       Diamond 
_diffrn_source.pdbx_synchrotron_beamline   I04-1 
_diffrn_source.pdbx_wavelength             ? 
# 
_reflns.entry_id                     7I2C 
_reflns.pdbx_diffrn_id               1 
_reflns.pdbx_ordinal                 1 
_reflns.d_resolution_low             74.55 
_reflns.d_resolution_high            1.63 
_reflns.number_obs                   90073 
_reflns.percent_possible_obs         100.0 
_reflns.pdbx_Rmerge_I_obs            0.129 
_reflns.pdbx_netI_over_sigmaI        10.6 
_reflns.pdbx_redundancy              13.1 
_reflns.pdbx_Rrim_I_all              0.134 
_reflns.pdbx_Rpim_I_all              0.037 
_reflns.pdbx_CC_half                 0.997 
_reflns.pdbx_number_measured_all     1183248 
_reflns.pdbx_chi_squared             0.40 
_reflns.observed_criterion_sigma_I   ? 
_reflns.observed_criterion_sigma_F   ? 
_reflns.number_all                   ? 
_reflns.pdbx_Rsym_value              ? 
_reflns.B_iso_Wilson_estimate        ? 
_reflns.pdbx_CC_star                 ? 
# 
_reflns_shell.pdbx_diffrn_id              1 
_reflns_shell.pdbx_ordinal                1 
_reflns_shell.d_res_high                  1.63 
_reflns_shell.d_res_low                   1.66 
_reflns_shell.number_measured_all         44836 
_reflns_shell.number_unique_obs           4383 
_reflns_shell.Rmerge_I_obs                5.049 
_reflns_shell.pdbx_chi_squared            0.14 
_reflns_shell.pdbx_redundancy             10.2 
_reflns_shell.percent_possible_obs        99.2 
_reflns_shell.pdbx_netI_over_sigmaI_obs   0.2 
_reflns_shell.pdbx_Rrim_I_all             5.315 
_reflns_shell.pdbx_Rpim_I_all             1.649 
_reflns_shell.pdbx_CC_half                0.383 
_reflns_shell.percent_possible_all        ? 
_reflns_shell.pdbx_Rsym_value             ? 
_reflns_shell.meanI_over_sigI_obs         ? 
_reflns_shell.number_measured_obs         ? 
_reflns_shell.number_unique_all           ? 
_reflns_shell.pdbx_CC_star                ? 
# 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.entry_id                                 7I2C 
_refine.pdbx_diffrn_id                           1 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     83526 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             74.55 
_refine.ls_d_res_high                            1.63 
_refine.ls_percent_reflns_obs                    97.68 
_refine.ls_R_factor_obs                          0.19510 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       0.19339 
_refine.ls_R_factor_R_free                       0.22614 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 5.1 
_refine.ls_number_reflns_R_free                  4492 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               0.965 
_refine.correlation_coeff_Fo_to_Fc_free          0.955 
_refine.B_iso_mean                               54.702 
_refine.aniso_B[1][1]                            -2.03 
_refine.aniso_B[2][2]                            0.58 
_refine.aniso_B[3][3]                            1.45 
_refine.aniso_B[1][2]                            -0.00 
_refine.aniso_B[1][3]                            0.00 
_refine.aniso_B[2][3]                            -0.00 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             1.20 
_refine.pdbx_solvent_ion_probe_radii             0.80 
_refine.pdbx_solvent_shrinkage_radii             0.80 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.details                                  'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_overall_ESU_R                       0.140 
_refine.pdbx_overall_ESU_R_Free                  0.124 
_refine.overall_SU_ML                            0.138 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             4.712 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         1 
_refine_hist.pdbx_number_atoms_protein        4682 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         70 
_refine_hist.number_atoms_solvent             398 
_refine_hist.number_atoms_total               5150 
_refine_hist.d_res_high                       1.63 
_refine_hist.d_res_low                        74.55 
# 
loop_
_refine_ls_restr.type 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.weight 
_refine_ls_restr.number 
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.pdbx_restraint_function 
r_bond_refined_d             0.008  0.014  ? 11219 'X-RAY DIFFRACTION' ? 
r_bond_other_d               0.001  0.015  ? 8040  'X-RAY DIFFRACTION' ? 
r_angle_refined_deg          1.414  1.641  ? 11726 'X-RAY DIFFRACTION' ? 
r_angle_other_deg            1.251  1.598  ? 18624 'X-RAY DIFFRACTION' ? 
r_dihedral_angle_1_deg       6.045  5.000  ? 1109  'X-RAY DIFFRACTION' ? 
r_dihedral_angle_2_deg       30.956 21.528 ? 504   'X-RAY DIFFRACTION' ? 
r_dihedral_angle_3_deg       17.166 15.000 ? 1613  'X-RAY DIFFRACTION' ? 
r_dihedral_angle_4_deg       16.595 15.000 ? 80    'X-RAY DIFFRACTION' ? 
r_chiral_restr               0.067  0.200  ? 1050  'X-RAY DIFFRACTION' ? 
r_gen_planes_refined         0.007  0.020  ? 10339 'X-RAY DIFFRACTION' ? 
r_gen_planes_other           0.002  0.020  ? 2157  'X-RAY DIFFRACTION' ? 
r_nbd_refined                ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbd_other                  ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbtor_refined              ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbtor_other                ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_xyhbond_nbd_refined        ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_xyhbond_nbd_other          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_metal_ion_refined          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_metal_ion_other            ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_vdw_refined       ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_vdw_other         ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_hbond_refined     ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_hbond_other       ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_metal_ion_refined ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_metal_ion_other   ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_mcbond_it                  2.893  5.454  ? 5409  'X-RAY DIFFRACTION' ? 
r_mcbond_other               2.927  5.466  ? 5284  'X-RAY DIFFRACTION' ? 
r_mcangle_it                 5.158  7.775  ? 5321  'X-RAY DIFFRACTION' ? 
r_mcangle_other              5.159  7.777  ? 5320  'X-RAY DIFFRACTION' ? 
r_scbond_it                  3.332  6.179  ? 5808  'X-RAY DIFFRACTION' ? 
r_scbond_other               3.332  6.179  ? 5808  'X-RAY DIFFRACTION' ? 
r_scangle_it                 ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_scangle_other              5.529  8.748  ? 6402  'X-RAY DIFFRACTION' ? 
r_long_range_B_refined       8.480  45.126 ? 8520  'X-RAY DIFFRACTION' ? 
r_long_range_B_other         8.403  44.821 ? 8405  'X-RAY DIFFRACTION' ? 
r_rigid_bond_restr           ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_sphericity_free            ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_sphericity_bonded          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.d_res_high                       1.630 
_refine_ls_shell.d_res_low                        1.672 
_refine_ls_shell.number_reflns_R_work             4960 
_refine_ls_shell.R_factor_R_work                  0.429 
_refine_ls_shell.percent_reflns_obs               78.53 
_refine_ls_shell.R_factor_R_free                  0.435 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.number_reflns_R_free             246 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.number_reflns_obs                ? 
# 
_struct.entry_id                  7I2C 
_struct.title                     
;Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 -- Crystal structure of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 in complex with Z71308235 (DNV2_NS5A-x0253)
;
_struct.pdbx_model_details        ? 
_struct.pdbx_CASP_flag            ? 
_struct.pdbx_model_type_details   ? 
# 
_struct_keywords.entry_id        7I2C 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
_struct_keywords.text            
;Diamond Light Source, I04-1, READDI, Dengue Virus, crystallographic fragment screening, PanDDA, XChemExplorer, cluster4x, VIRAL PROTEIN
;
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 2 ? 
D N N 3 ? 
E N N 4 ? 
F N N 4 ? 
G N N 4 ? 
H N N 5 ? 
I N N 6 ? 
J N N 6 ? 
K N N 5 ? 
L N N 7 ? 
M N N 8 ? 
N N N 9 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    Q91H74_9FLAV 
_struct_ref.pdbx_db_accession          Q91H74 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;GIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAMTD
TTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAREA
VEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENSLS
GVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRPTP
RGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGDDC
VVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQGAG
WSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPWME
DKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_struct_ref.pdbx_align_begin           2757 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              7I2C 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 3 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 637 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q91H74 
_struct_ref_seq.db_align_beg                  2757 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  3391 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       266 
_struct_ref_seq.pdbx_auth_seq_align_end       900 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 7I2C GLY A 1 ? UNP Q91H74 ? ? 'expression tag' 264 1 
1 7I2C PRO A 2 ? UNP Q91H74 ? ? 'expression tag' 265 2 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L,M,N 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASN A 10  ? HIS A 25  ? ASN A 273 HIS A 288 1 ? 16 
HELX_P HELX_P2  AA2 ASN A 59  ? LEU A 65  ? ASN A 322 LEU A 328 1 ? 7  
HELX_P HELX_P3  AA3 THR A 66  ? ILE A 71  ? THR A 329 ILE A 334 5 ? 6  
HELX_P HELX_P4  AA4 ILE A 72  ? GLN A 77  ? ILE A 335 GLN A 340 1 ? 6  
HELX_P HELX_P5  AA5 MET A 78  ? MET A 80  ? MET A 341 MET A 343 5 ? 3  
HELX_P HELX_P6  AA6 LYS A 104 ? LYS A 124 ? LYS A 367 LYS A 387 1 ? 21 
HELX_P HELX_P7  AA7 THR A 132 ? ARG A 141 ? THR A 395 ARG A 404 1 ? 10 
HELX_P HELX_P8  AA8 SER A 158 ? GLU A 164 ? SER A 421 GLU A 427 1 ? 7  
HELX_P HELX_P9  AA9 ASP A 165 ? GLU A 181 ? ASP A 428 GLU A 444 1 ? 17 
HELX_P HELX_P10 AB1 TRP A 215 ? GLY A 227 ? TRP A 478 GLY A 490 1 ? 13 
HELX_P HELX_P11 AB2 GLY A 227 ? ASP A 232 ? GLY A 490 ASP A 495 1 ? 6  
HELX_P HELX_P12 AB3 SER A 236 ? LEU A 241 ? SER A 499 LEU A 504 1 ? 6  
HELX_P HELX_P13 AB4 GLY A 248 ? LYS A 261 ? GLY A 511 LYS A 524 1 ? 14 
HELX_P HELX_P14 AB5 GLY A 274 ? ILE A 279 ? GLY A 537 ILE A 542 5 ? 6  
HELX_P HELX_P15 AB6 THR A 280 ? MET A 289 ? THR A 543 MET A 552 1 ? 10 
HELX_P HELX_P16 AB7 VAL A 290 ? MET A 294 ? VAL A 553 MET A 557 5 ? 5  
HELX_P HELX_P17 AB8 GLU A 295 ? TYR A 310 ? GLU A 558 TYR A 573 1 ? 16 
HELX_P HELX_P18 AB9 GLY A 339 ? GLU A 363 ? GLY A 602 GLU A 626 1 ? 25 
HELX_P HELX_P19 AC1 THR A 373 ? SER A 393 ? THR A 636 SER A 656 1 ? 21 
HELX_P HELX_P20 AC2 ASP A 408 ? ALA A 414 ? ASP A 671 ALA A 677 5 ? 7  
HELX_P HELX_P21 AC3 LEU A 415 ? MET A 421 ? LEU A 678 MET A 684 1 ? 7  
HELX_P HELX_P22 AC4 ASP A 439 ? VAL A 443 ? ASP A 702 VAL A 706 5 ? 5  
HELX_P HELX_P23 AC5 ASN A 467 ? ARG A 476 ? ASN A 730 ARG A 739 1 ? 10 
HELX_P HELX_P24 AC6 SER A 484 ? TYR A 503 ? SER A 747 TYR A 766 1 ? 20 
HELX_P HELX_P25 AC7 ARG A 506 ? VAL A 520 ? ARG A 769 VAL A 783 1 ? 15 
HELX_P HELX_P26 AC8 ASP A 545 ? ILE A 555 ? ASP A 808 ILE A 818 1 ? 11 
HELX_P HELX_P27 AC9 SER A 569 ? ILE A 573 ? SER A 832 ILE A 836 5 ? 5  
HELX_P HELX_P28 AD1 GLY A 577 ? CYS A 584 ? GLY A 840 CYS A 847 1 ? 8  
HELX_P HELX_P29 AD2 LEU A 590 ? ASN A 599 ? LEU A 853 ASN A 862 1 ? 10 
HELX_P HELX_P30 AD3 ASN A 599 ? GLY A 612 ? ASN A 862 GLY A 875 1 ? 14 
HELX_P HELX_P31 AD4 TYR A 619 ? MET A 623 ? TYR A 882 MET A 886 5 ? 5  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1 metalc ? ? A GLU 175 OE1 ? ? ? 1_555 C ZN . ZN ? ? A GLU 438 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.029 ? ? 
metalc2 metalc ? ? A HIS 179 NE2 ? ? ? 1_555 C ZN . ZN ? ? A HIS 442 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.095 ? ? 
metalc3 metalc ? ? A CYS 184 SG  ? ? ? 1_555 C ZN . ZN ? ? A CYS 447 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.207 ? ? 
metalc4 metalc ? ? A CYS 187 SG  ? ? ? 1_555 C ZN . ZN ? ? A CYS 450 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.085 ? ? 
metalc5 metalc ? ? A HIS 449 NE2 ? ? ? 1_555 B ZN . ZN ? ? A HIS 712 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.098 ? ? 
metalc6 metalc ? ? A HIS 451 NE2 ? ? ? 1_555 B ZN . ZN ? ? A HIS 714 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.023 ? ? 
metalc7 metalc ? ? A CYS 465 SG  ? ? ? 1_555 B ZN . ZN ? ? A CYS 728 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.379 ? ? 
metalc8 metalc ? ? A CYS 584 SG  ? ? ? 1_555 B ZN . ZN ? ? A CYS 847 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.316 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  OE1 ? A GLU 175 ? A GLU 438 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 NE2 ? A HIS 179 ? A HIS 442 ? 1_555 107.0 ? 
2  OE1 ? A GLU 175 ? A GLU 438 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 184 ? A CYS 447 ? 1_555 116.3 ? 
3  NE2 ? A HIS 179 ? A HIS 442 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 184 ? A CYS 447 ? 1_555 119.8 ? 
4  OE1 ? A GLU 175 ? A GLU 438 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 83.2  ? 
5  NE2 ? A HIS 179 ? A HIS 442 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 112.1 ? 
6  SG  ? A CYS 184 ? A CYS 447 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 112.5 ? 
7  NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 NE2 ? A HIS 451 ? A HIS 714 ? 1_555 103.0 ? 
8  NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 465 ? A CYS 728 ? 1_555 105.4 ? 
9  NE2 ? A HIS 451 ? A HIS 714 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 465 ? A CYS 728 ? 1_555 107.8 ? 
10 NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 105.7 ? 
11 NE2 ? A HIS 451 ? A HIS 714 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 116.3 ? 
12 SG  ? A CYS 465 ? A CYS 728 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 117.1 ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 2 ? 
AA3 ? 2 ? 
AA4 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? parallel      
AA1 4 5 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ALA A 41  ? GLY A 44  ? ALA A 304 GLY A 307 
AA1 2 VAL A 326 ? ARG A 332 ? VAL A 589 ARG A 595 
AA1 3 LYS A 313 ? ARG A 319 ? LYS A 576 ARG A 582 
AA1 4 TYR A 189 ? MET A 191 ? TYR A 452 MET A 454 
AA1 5 TRP A 212 ? TYR A 213 ? TRP A 475 TYR A 476 
AA2 1 SER A 56  ? VAL A 58  ? SER A 319 VAL A 321 
AA2 2 ILE A 477 ? GLN A 479 ? ILE A 740 GLN A 742 
AA3 1 MET A 395 ? SER A 398 ? MET A 658 SER A 661 
AA3 2 ASP A 401 ? VAL A 404 ? ASP A 664 VAL A 667 
AA4 1 HIS A 449 ? ILE A 454 ? HIS A 712 ILE A 717 
AA4 2 VAL A 460 ? CYS A 465 ? VAL A 723 CYS A 728 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ALA A 41  ? N ALA A 304 O SER A 331 ? O SER A 594 
AA1 2 3 O ILE A 330 ? O ILE A 593 N VAL A 315 ? N VAL A 578 
AA1 3 4 O VAL A 314 ? O VAL A 577 N TYR A 189 ? N TYR A 452 
AA1 4 5 N ASN A 190 ? N ASN A 453 O TYR A 213 ? O TYR A 476 
AA2 1 2 N MET A 57  ? N MET A 320 O SER A 478 ? O SER A 741 
AA3 1 2 N SER A 398 ? N SER A 661 O ASP A 401 ? O ASP A 664 
AA4 1 2 N LEU A 453 ? N LEU A 716 O LEU A 461 ? O LEU A 724 
# 
_pdbx_entry_details.entry_id                   7I2C 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_close_contact.id               1 
_pdbx_validate_close_contact.PDB_model_num    1 
_pdbx_validate_close_contact.auth_atom_id_1   OD1 
_pdbx_validate_close_contact.auth_asym_id_1   A 
_pdbx_validate_close_contact.auth_comp_id_1   ASP 
_pdbx_validate_close_contact.auth_seq_id_1    664 
_pdbx_validate_close_contact.PDB_ins_code_1   ? 
_pdbx_validate_close_contact.label_alt_id_1   ? 
_pdbx_validate_close_contact.auth_atom_id_2   O4 
_pdbx_validate_close_contact.auth_asym_id_2   A 
_pdbx_validate_close_contact.auth_comp_id_2   PO4 
_pdbx_validate_close_contact.auth_seq_id_2    1008 
_pdbx_validate_close_contact.PDB_ins_code_2   ? 
_pdbx_validate_close_contact.label_alt_id_2   ? 
_pdbx_validate_close_contact.dist             2.00 
# 
_pdbx_validate_symm_contact.id                1 
_pdbx_validate_symm_contact.PDB_model_num     1 
_pdbx_validate_symm_contact.auth_atom_id_1    O 
_pdbx_validate_symm_contact.auth_asym_id_1    A 
_pdbx_validate_symm_contact.auth_comp_id_1    HOH 
_pdbx_validate_symm_contact.auth_seq_id_1     1175 
_pdbx_validate_symm_contact.PDB_ins_code_1    ? 
_pdbx_validate_symm_contact.label_alt_id_1    ? 
_pdbx_validate_symm_contact.site_symmetry_1   1_555 
_pdbx_validate_symm_contact.auth_atom_id_2    O 
_pdbx_validate_symm_contact.auth_asym_id_2    A 
_pdbx_validate_symm_contact.auth_comp_id_2    HOH 
_pdbx_validate_symm_contact.auth_seq_id_2     1175 
_pdbx_validate_symm_contact.PDB_ins_code_2    ? 
_pdbx_validate_symm_contact.label_alt_id_2    ? 
_pdbx_validate_symm_contact.site_symmetry_2   2_445 
_pdbx_validate_symm_contact.dist              1.68 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 ASP A 297 ? ? -94.39  38.63  
2  1 HIS A 306 ? ? -131.85 -34.82 
3  1 TYR A 309 ? ? -176.83 145.40 
4  1 LYS A 358 ? ? -136.96 -32.16 
5  1 ASP A 360 ? ? -88.81  34.28  
6  1 ASN A 406 ? ? 54.02   107.76 
7  1 LYS A 420 ? ? -97.41  -90.75 
8  1 GLU A 427 ? ? -91.30  45.75  
9  1 LEU A 504 ? ? 72.02   -42.67 
10 1 ASN A 575 ? ? -155.75 83.76  
11 1 GLN A 598 ? ? 78.25   155.98 
12 1 HIS A 801 ? A -103.77 69.95  
13 1 HIS A 801 ? B -101.03 64.98  
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A MES 1003 ? D MES . 
2 1 A HOH 1161 ? N HOH . 
3 1 A HOH 1211 ? N HOH . 
4 1 A HOH 1431 ? N HOH . 
5 1 A HOH 1452 ? N HOH . 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 1496 ? 5.90 . 
2 1 O ? A HOH 1497 ? 5.96 . 
3 1 O ? A HOH 1498 ? 6.55 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY 264 ? A GLY 1   
2  1 Y 1 A PRO 265 ? A PRO 2   
3  1 Y 1 A GLY 266 ? A GLY 3   
4  1 Y 1 A ILE 267 ? A ILE 4   
5  1 Y 1 A GLU 268 ? A GLU 5   
6  1 Y 1 A SER 269 ? A SER 6   
7  1 Y 1 A GLU 270 ? A GLU 7   
8  1 Y 1 A THR 271 ? A THR 8   
9  1 Y 1 A PRO 272 ? A PRO 9   
10 1 Y 1 A LYS 312 ? A LYS 49  
11 1 Y 1 A GLN 313 ? A GLN 50  
12 1 Y 1 A THR 314 ? A THR 51  
13 1 Y 1 A GLY 315 ? A GLY 52  
14 1 Y 1 A SER 316 ? A SER 53  
15 1 Y 1 A ALA 317 ? A ALA 54  
16 1 Y 1 A ASP 345 ? A ASP 82  
17 1 Y 1 A THR 346 ? A THR 83  
18 1 Y 1 A THR 347 ? A THR 84  
19 1 Y 1 A PRO 348 ? A PRO 85  
20 1 Y 1 A PHE 349 ? A PHE 86  
21 1 Y 1 A GLY 350 ? A GLY 87  
22 1 Y 1 A GLN 351 ? A GLN 88  
23 1 Y 1 A GLN 352 ? A GLN 89  
24 1 Y 1 A ARG 353 ? A ARG 90  
25 1 Y 1 A VAL 354 ? A VAL 91  
26 1 Y 1 A PHE 355 ? A PHE 92  
27 1 Y 1 A PHE 413 ? A PHE 150 
28 1 Y 1 A THR 414 ? A THR 151 
29 1 Y 1 A ASP 415 ? A ASP 152 
30 1 Y 1 A GLU 416 ? A GLU 153 
31 1 Y 1 A ASN 417 ? A ASN 154 
32 1 Y 1 A GLY 456 ? A GLY 193 
33 1 Y 1 A LYS 457 ? A LYS 194 
34 1 Y 1 A ARG 458 ? A ARG 195 
35 1 Y 1 A GLU 459 ? A GLU 196 
36 1 Y 1 A LYS 460 ? A LYS 197 
37 1 Y 1 A LYS 461 ? A LYS 198 
38 1 Y 1 A LEU 462 ? A LEU 199 
39 1 Y 1 A GLY 463 ? A GLY 200 
40 1 Y 1 A GLU 464 ? A GLU 201 
41 1 Y 1 A PHE 465 ? A PHE 202 
42 1 Y 1 A GLY 466 ? A GLY 203 
43 1 Y 1 A LYS 467 ? A LYS 204 
44 1 Y 1 A ALA 468 ? A ALA 205 
45 1 Y 1 A LYS 469 ? A LYS 206 
46 1 Y 1 A GLY 470 ? A GLY 207 
47 1 Y 1 A SER 471 ? A SER 208 
48 1 Y 1 A ARG 472 ? A ARG 209 
49 1 Y 1 A PRO 585 ? A PRO 322 
50 1 Y 1 A ARG 586 ? A ARG 323 
51 1 Y 1 A GLY 587 ? A GLY 324 
52 1 Y 1 A TRP 795 ? A TRP 532 
53 1 Y 1 A SER 796 ? A SER 533 
54 1 Y 1 A ILE 797 ? A ILE 534 
55 1 Y 1 A HIS 798 ? A HIS 535 
56 1 Y 1 A GLU 892 ? A GLU 629 
57 1 Y 1 A GLU 893 ? A GLU 630 
58 1 Y 1 A GLU 894 ? A GLU 631 
59 1 Y 1 A GLU 895 ? A GLU 632 
60 1 Y 1 A ALA 896 ? A ALA 633 
61 1 Y 1 A GLY 897 ? A GLY 634 
62 1 Y 1 A VAL 898 ? A VAL 635 
63 1 Y 1 A LEU 899 ? A LEU 636 
64 1 Y 1 A TRP 900 ? A TRP 637 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1BZP N1   N  Y N 1   
A1BZP C4   C  N N 2   
A1BZP C5   C  Y N 3   
A1BZP C6   C  Y N 4   
A1BZP C7   C  Y N 5   
A1BZP C8   C  Y N 6   
A1BZP C10  C  Y N 7   
A1BZP N    N  Y N 8   
A1BZP C    C  N N 9   
A1BZP O    O  N N 10  
A1BZP C1   C  Y N 11  
A1BZP C11  C  Y N 12  
A1BZP C2   C  N N 13  
A1BZP C3   C  Y N 14  
A1BZP C9   C  Y N 15  
A1BZP F    F  N N 16  
A1BZP N2   N  N N 17  
A1BZP O1   O  N N 18  
A1BZP S    S  N N 19  
A1BZP H7   H  N N 20  
A1BZP H6   H  N N 21  
A1BZP H8   H  N N 22  
A1BZP H10  H  N N 23  
A1BZP H11  H  N N 24  
A1BZP H1   H  N N 25  
A1BZP H2   H  N N 26  
A1BZP H    H  N N 27  
A1BZP H13  H  N N 28  
A1BZP H4   H  N N 29  
A1BZP H3   H  N N 30  
A1BZP H5   H  N N 31  
A1BZP H12  H  N N 32  
A1BZP H9   H  N N 33  
ALA   N    N  N N 34  
ALA   CA   C  N S 35  
ALA   C    C  N N 36  
ALA   O    O  N N 37  
ALA   CB   C  N N 38  
ALA   OXT  O  N N 39  
ALA   H    H  N N 40  
ALA   H2   H  N N 41  
ALA   HA   H  N N 42  
ALA   HB1  H  N N 43  
ALA   HB2  H  N N 44  
ALA   HB3  H  N N 45  
ALA   HXT  H  N N 46  
ARG   N    N  N N 47  
ARG   CA   C  N S 48  
ARG   C    C  N N 49  
ARG   O    O  N N 50  
ARG   CB   C  N N 51  
ARG   CG   C  N N 52  
ARG   CD   C  N N 53  
ARG   NE   N  N N 54  
ARG   CZ   C  N N 55  
ARG   NH1  N  N N 56  
ARG   NH2  N  N N 57  
ARG   OXT  O  N N 58  
ARG   H    H  N N 59  
ARG   H2   H  N N 60  
ARG   HA   H  N N 61  
ARG   HB2  H  N N 62  
ARG   HB3  H  N N 63  
ARG   HG2  H  N N 64  
ARG   HG3  H  N N 65  
ARG   HD2  H  N N 66  
ARG   HD3  H  N N 67  
ARG   HE   H  N N 68  
ARG   HH11 H  N N 69  
ARG   HH12 H  N N 70  
ARG   HH21 H  N N 71  
ARG   HH22 H  N N 72  
ARG   HXT  H  N N 73  
ASN   N    N  N N 74  
ASN   CA   C  N S 75  
ASN   C    C  N N 76  
ASN   O    O  N N 77  
ASN   CB   C  N N 78  
ASN   CG   C  N N 79  
ASN   OD1  O  N N 80  
ASN   ND2  N  N N 81  
ASN   OXT  O  N N 82  
ASN   H    H  N N 83  
ASN   H2   H  N N 84  
ASN   HA   H  N N 85  
ASN   HB2  H  N N 86  
ASN   HB3  H  N N 87  
ASN   HD21 H  N N 88  
ASN   HD22 H  N N 89  
ASN   HXT  H  N N 90  
ASP   N    N  N N 91  
ASP   CA   C  N S 92  
ASP   C    C  N N 93  
ASP   O    O  N N 94  
ASP   CB   C  N N 95  
ASP   CG   C  N N 96  
ASP   OD1  O  N N 97  
ASP   OD2  O  N N 98  
ASP   OXT  O  N N 99  
ASP   H    H  N N 100 
ASP   H2   H  N N 101 
ASP   HA   H  N N 102 
ASP   HB2  H  N N 103 
ASP   HB3  H  N N 104 
ASP   HD2  H  N N 105 
ASP   HXT  H  N N 106 
CL    CL   CL N N 107 
CYS   N    N  N N 108 
CYS   CA   C  N R 109 
CYS   C    C  N N 110 
CYS   O    O  N N 111 
CYS   CB   C  N N 112 
CYS   SG   S  N N 113 
CYS   OXT  O  N N 114 
CYS   H    H  N N 115 
CYS   H2   H  N N 116 
CYS   HA   H  N N 117 
CYS   HB2  H  N N 118 
CYS   HB3  H  N N 119 
CYS   HG   H  N N 120 
CYS   HXT  H  N N 121 
DMS   S    S  N N 122 
DMS   O    O  N N 123 
DMS   C1   C  N N 124 
DMS   C2   C  N N 125 
DMS   H11  H  N N 126 
DMS   H12  H  N N 127 
DMS   H13  H  N N 128 
DMS   H21  H  N N 129 
DMS   H22  H  N N 130 
DMS   H23  H  N N 131 
GLN   N    N  N N 132 
GLN   CA   C  N S 133 
GLN   C    C  N N 134 
GLN   O    O  N N 135 
GLN   CB   C  N N 136 
GLN   CG   C  N N 137 
GLN   CD   C  N N 138 
GLN   OE1  O  N N 139 
GLN   NE2  N  N N 140 
GLN   OXT  O  N N 141 
GLN   H    H  N N 142 
GLN   H2   H  N N 143 
GLN   HA   H  N N 144 
GLN   HB2  H  N N 145 
GLN   HB3  H  N N 146 
GLN   HG2  H  N N 147 
GLN   HG3  H  N N 148 
GLN   HE21 H  N N 149 
GLN   HE22 H  N N 150 
GLN   HXT  H  N N 151 
GLU   N    N  N N 152 
GLU   CA   C  N S 153 
GLU   C    C  N N 154 
GLU   O    O  N N 155 
GLU   CB   C  N N 156 
GLU   CG   C  N N 157 
GLU   CD   C  N N 158 
GLU   OE1  O  N N 159 
GLU   OE2  O  N N 160 
GLU   OXT  O  N N 161 
GLU   H    H  N N 162 
GLU   H2   H  N N 163 
GLU   HA   H  N N 164 
GLU   HB2  H  N N 165 
GLU   HB3  H  N N 166 
GLU   HG2  H  N N 167 
GLU   HG3  H  N N 168 
GLU   HE2  H  N N 169 
GLU   HXT  H  N N 170 
GLY   N    N  N N 171 
GLY   CA   C  N N 172 
GLY   C    C  N N 173 
GLY   O    O  N N 174 
GLY   OXT  O  N N 175 
GLY   H    H  N N 176 
GLY   H2   H  N N 177 
GLY   HA2  H  N N 178 
GLY   HA3  H  N N 179 
GLY   HXT  H  N N 180 
HIS   N    N  N N 181 
HIS   CA   C  N S 182 
HIS   C    C  N N 183 
HIS   O    O  N N 184 
HIS   CB   C  N N 185 
HIS   CG   C  Y N 186 
HIS   ND1  N  Y N 187 
HIS   CD2  C  Y N 188 
HIS   CE1  C  Y N 189 
HIS   NE2  N  Y N 190 
HIS   OXT  O  N N 191 
HIS   H    H  N N 192 
HIS   H2   H  N N 193 
HIS   HA   H  N N 194 
HIS   HB2  H  N N 195 
HIS   HB3  H  N N 196 
HIS   HD1  H  N N 197 
HIS   HD2  H  N N 198 
HIS   HE1  H  N N 199 
HIS   HE2  H  N N 200 
HIS   HXT  H  N N 201 
HOH   O    O  N N 202 
HOH   H1   H  N N 203 
HOH   H2   H  N N 204 
ILE   N    N  N N 205 
ILE   CA   C  N S 206 
ILE   C    C  N N 207 
ILE   O    O  N N 208 
ILE   CB   C  N S 209 
ILE   CG1  C  N N 210 
ILE   CG2  C  N N 211 
ILE   CD1  C  N N 212 
ILE   OXT  O  N N 213 
ILE   H    H  N N 214 
ILE   H2   H  N N 215 
ILE   HA   H  N N 216 
ILE   HB   H  N N 217 
ILE   HG12 H  N N 218 
ILE   HG13 H  N N 219 
ILE   HG21 H  N N 220 
ILE   HG22 H  N N 221 
ILE   HG23 H  N N 222 
ILE   HD11 H  N N 223 
ILE   HD12 H  N N 224 
ILE   HD13 H  N N 225 
ILE   HXT  H  N N 226 
LEU   N    N  N N 227 
LEU   CA   C  N S 228 
LEU   C    C  N N 229 
LEU   O    O  N N 230 
LEU   CB   C  N N 231 
LEU   CG   C  N N 232 
LEU   CD1  C  N N 233 
LEU   CD2  C  N N 234 
LEU   OXT  O  N N 235 
LEU   H    H  N N 236 
LEU   H2   H  N N 237 
LEU   HA   H  N N 238 
LEU   HB2  H  N N 239 
LEU   HB3  H  N N 240 
LEU   HG   H  N N 241 
LEU   HD11 H  N N 242 
LEU   HD12 H  N N 243 
LEU   HD13 H  N N 244 
LEU   HD21 H  N N 245 
LEU   HD22 H  N N 246 
LEU   HD23 H  N N 247 
LEU   HXT  H  N N 248 
LYS   N    N  N N 249 
LYS   CA   C  N S 250 
LYS   C    C  N N 251 
LYS   O    O  N N 252 
LYS   CB   C  N N 253 
LYS   CG   C  N N 254 
LYS   CD   C  N N 255 
LYS   CE   C  N N 256 
LYS   NZ   N  N N 257 
LYS   OXT  O  N N 258 
LYS   H    H  N N 259 
LYS   H2   H  N N 260 
LYS   HA   H  N N 261 
LYS   HB2  H  N N 262 
LYS   HB3  H  N N 263 
LYS   HG2  H  N N 264 
LYS   HG3  H  N N 265 
LYS   HD2  H  N N 266 
LYS   HD3  H  N N 267 
LYS   HE2  H  N N 268 
LYS   HE3  H  N N 269 
LYS   HZ1  H  N N 270 
LYS   HZ2  H  N N 271 
LYS   HZ3  H  N N 272 
LYS   HXT  H  N N 273 
MES   O1   O  N N 274 
MES   C2   C  N N 275 
MES   C3   C  N N 276 
MES   N4   N  N N 277 
MES   C5   C  N N 278 
MES   C6   C  N N 279 
MES   C7   C  N N 280 
MES   C8   C  N N 281 
MES   S    S  N N 282 
MES   O1S  O  N N 283 
MES   O2S  O  N N 284 
MES   O3S  O  N N 285 
MES   H21  H  N N 286 
MES   H22  H  N N 287 
MES   H31  H  N N 288 
MES   H32  H  N N 289 
MES   HN4  H  N N 290 
MES   H51  H  N N 291 
MES   H52  H  N N 292 
MES   H61  H  N N 293 
MES   H62  H  N N 294 
MES   H71  H  N N 295 
MES   H72  H  N N 296 
MES   H81  H  N N 297 
MES   H82  H  N N 298 
MET   N    N  N N 299 
MET   CA   C  N S 300 
MET   C    C  N N 301 
MET   O    O  N N 302 
MET   CB   C  N N 303 
MET   CG   C  N N 304 
MET   SD   S  N N 305 
MET   CE   C  N N 306 
MET   OXT  O  N N 307 
MET   H    H  N N 308 
MET   H2   H  N N 309 
MET   HA   H  N N 310 
MET   HB2  H  N N 311 
MET   HB3  H  N N 312 
MET   HG2  H  N N 313 
MET   HG3  H  N N 314 
MET   HE1  H  N N 315 
MET   HE2  H  N N 316 
MET   HE3  H  N N 317 
MET   HXT  H  N N 318 
PEG   C1   C  N N 319 
PEG   O1   O  N N 320 
PEG   C2   C  N N 321 
PEG   O2   O  N N 322 
PEG   C3   C  N N 323 
PEG   C4   C  N N 324 
PEG   O4   O  N N 325 
PEG   H11  H  N N 326 
PEG   H12  H  N N 327 
PEG   HO1  H  N N 328 
PEG   H21  H  N N 329 
PEG   H22  H  N N 330 
PEG   H31  H  N N 331 
PEG   H32  H  N N 332 
PEG   H41  H  N N 333 
PEG   H42  H  N N 334 
PEG   HO4  H  N N 335 
PHE   N    N  N N 336 
PHE   CA   C  N S 337 
PHE   C    C  N N 338 
PHE   O    O  N N 339 
PHE   CB   C  N N 340 
PHE   CG   C  Y N 341 
PHE   CD1  C  Y N 342 
PHE   CD2  C  Y N 343 
PHE   CE1  C  Y N 344 
PHE   CE2  C  Y N 345 
PHE   CZ   C  Y N 346 
PHE   OXT  O  N N 347 
PHE   H    H  N N 348 
PHE   H2   H  N N 349 
PHE   HA   H  N N 350 
PHE   HB2  H  N N 351 
PHE   HB3  H  N N 352 
PHE   HD1  H  N N 353 
PHE   HD2  H  N N 354 
PHE   HE1  H  N N 355 
PHE   HE2  H  N N 356 
PHE   HZ   H  N N 357 
PHE   HXT  H  N N 358 
PO4   P    P  N N 359 
PO4   O1   O  N N 360 
PO4   O2   O  N N 361 
PO4   O3   O  N N 362 
PO4   O4   O  N N 363 
PRO   N    N  N N 364 
PRO   CA   C  N S 365 
PRO   C    C  N N 366 
PRO   O    O  N N 367 
PRO   CB   C  N N 368 
PRO   CG   C  N N 369 
PRO   CD   C  N N 370 
PRO   OXT  O  N N 371 
PRO   H    H  N N 372 
PRO   HA   H  N N 373 
PRO   HB2  H  N N 374 
PRO   HB3  H  N N 375 
PRO   HG2  H  N N 376 
PRO   HG3  H  N N 377 
PRO   HD2  H  N N 378 
PRO   HD3  H  N N 379 
PRO   HXT  H  N N 380 
SER   N    N  N N 381 
SER   CA   C  N S 382 
SER   C    C  N N 383 
SER   O    O  N N 384 
SER   CB   C  N N 385 
SER   OG   O  N N 386 
SER   OXT  O  N N 387 
SER   H    H  N N 388 
SER   H2   H  N N 389 
SER   HA   H  N N 390 
SER   HB2  H  N N 391 
SER   HB3  H  N N 392 
SER   HG   H  N N 393 
SER   HXT  H  N N 394 
THR   N    N  N N 395 
THR   CA   C  N S 396 
THR   C    C  N N 397 
THR   O    O  N N 398 
THR   CB   C  N R 399 
THR   OG1  O  N N 400 
THR   CG2  C  N N 401 
THR   OXT  O  N N 402 
THR   H    H  N N 403 
THR   H2   H  N N 404 
THR   HA   H  N N 405 
THR   HB   H  N N 406 
THR   HG1  H  N N 407 
THR   HG21 H  N N 408 
THR   HG22 H  N N 409 
THR   HG23 H  N N 410 
THR   HXT  H  N N 411 
TRP   N    N  N N 412 
TRP   CA   C  N S 413 
TRP   C    C  N N 414 
TRP   O    O  N N 415 
TRP   CB   C  N N 416 
TRP   CG   C  Y N 417 
TRP   CD1  C  Y N 418 
TRP   CD2  C  Y N 419 
TRP   NE1  N  Y N 420 
TRP   CE2  C  Y N 421 
TRP   CE3  C  Y N 422 
TRP   CZ2  C  Y N 423 
TRP   CZ3  C  Y N 424 
TRP   CH2  C  Y N 425 
TRP   OXT  O  N N 426 
TRP   H    H  N N 427 
TRP   H2   H  N N 428 
TRP   HA   H  N N 429 
TRP   HB2  H  N N 430 
TRP   HB3  H  N N 431 
TRP   HD1  H  N N 432 
TRP   HE1  H  N N 433 
TRP   HE3  H  N N 434 
TRP   HZ2  H  N N 435 
TRP   HZ3  H  N N 436 
TRP   HH2  H  N N 437 
TRP   HXT  H  N N 438 
TYR   N    N  N N 439 
TYR   CA   C  N S 440 
TYR   C    C  N N 441 
TYR   O    O  N N 442 
TYR   CB   C  N N 443 
TYR   CG   C  Y N 444 
TYR   CD1  C  Y N 445 
TYR   CD2  C  Y N 446 
TYR   CE1  C  Y N 447 
TYR   CE2  C  Y N 448 
TYR   CZ   C  Y N 449 
TYR   OH   O  N N 450 
TYR   OXT  O  N N 451 
TYR   H    H  N N 452 
TYR   H2   H  N N 453 
TYR   HA   H  N N 454 
TYR   HB2  H  N N 455 
TYR   HB3  H  N N 456 
TYR   HD1  H  N N 457 
TYR   HD2  H  N N 458 
TYR   HE1  H  N N 459 
TYR   HE2  H  N N 460 
TYR   HH   H  N N 461 
TYR   HXT  H  N N 462 
VAL   N    N  N N 463 
VAL   CA   C  N S 464 
VAL   C    C  N N 465 
VAL   O    O  N N 466 
VAL   CB   C  N N 467 
VAL   CG1  C  N N 468 
VAL   CG2  C  N N 469 
VAL   OXT  O  N N 470 
VAL   H    H  N N 471 
VAL   H2   H  N N 472 
VAL   HA   H  N N 473 
VAL   HB   H  N N 474 
VAL   HG11 H  N N 475 
VAL   HG12 H  N N 476 
VAL   HG13 H  N N 477 
VAL   HG21 H  N N 478 
VAL   HG22 H  N N 479 
VAL   HG23 H  N N 480 
VAL   HXT  H  N N 481 
ZN    ZN   ZN N N 482 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1BZP C   C1   sing N N 1   
A1BZP C1  N    doub Y N 2   
A1BZP N   N1   sing Y N 3   
A1BZP C2  N1   sing N N 4   
A1BZP N1  C3   sing Y N 5   
A1BZP C4  C3   sing N N 6   
A1BZP C3  C5   doub Y N 7   
A1BZP C1  C5   sing Y N 8   
A1BZP C5  N2   sing N N 9   
A1BZP N2  S    sing N N 10  
A1BZP O   S    doub N N 11  
A1BZP O1  S    doub N N 12  
A1BZP S   C6   sing N N 13  
A1BZP C6  C7   doub Y N 14  
A1BZP C7  C8   sing Y N 15  
A1BZP C8  C9   doub Y N 16  
A1BZP C9  C10  sing Y N 17  
A1BZP C10 F    sing N N 18  
A1BZP C11 C10  doub Y N 19  
A1BZP C6  C11  sing Y N 20  
A1BZP C4  H7   sing N N 21  
A1BZP C4  H6   sing N N 22  
A1BZP C4  H8   sing N N 23  
A1BZP C7  H10  sing N N 24  
A1BZP C8  H11  sing N N 25  
A1BZP C   H1   sing N N 26  
A1BZP C   H2   sing N N 27  
A1BZP C   H    sing N N 28  
A1BZP C11 H13  sing N N 29  
A1BZP C2  H4   sing N N 30  
A1BZP C2  H3   sing N N 31  
A1BZP C2  H5   sing N N 32  
A1BZP C9  H12  sing N N 33  
A1BZP N2  H9   sing N N 34  
ALA   N   CA   sing N N 35  
ALA   N   H    sing N N 36  
ALA   N   H2   sing N N 37  
ALA   CA  C    sing N N 38  
ALA   CA  CB   sing N N 39  
ALA   CA  HA   sing N N 40  
ALA   C   O    doub N N 41  
ALA   C   OXT  sing N N 42  
ALA   CB  HB1  sing N N 43  
ALA   CB  HB2  sing N N 44  
ALA   CB  HB3  sing N N 45  
ALA   OXT HXT  sing N N 46  
ARG   N   CA   sing N N 47  
ARG   N   H    sing N N 48  
ARG   N   H2   sing N N 49  
ARG   CA  C    sing N N 50  
ARG   CA  CB   sing N N 51  
ARG   CA  HA   sing N N 52  
ARG   C   O    doub N N 53  
ARG   C   OXT  sing N N 54  
ARG   CB  CG   sing N N 55  
ARG   CB  HB2  sing N N 56  
ARG   CB  HB3  sing N N 57  
ARG   CG  CD   sing N N 58  
ARG   CG  HG2  sing N N 59  
ARG   CG  HG3  sing N N 60  
ARG   CD  NE   sing N N 61  
ARG   CD  HD2  sing N N 62  
ARG   CD  HD3  sing N N 63  
ARG   NE  CZ   sing N N 64  
ARG   NE  HE   sing N N 65  
ARG   CZ  NH1  sing N N 66  
ARG   CZ  NH2  doub N N 67  
ARG   NH1 HH11 sing N N 68  
ARG   NH1 HH12 sing N N 69  
ARG   NH2 HH21 sing N N 70  
ARG   NH2 HH22 sing N N 71  
ARG   OXT HXT  sing N N 72  
ASN   N   CA   sing N N 73  
ASN   N   H    sing N N 74  
ASN   N   H2   sing N N 75  
ASN   CA  C    sing N N 76  
ASN   CA  CB   sing N N 77  
ASN   CA  HA   sing N N 78  
ASN   C   O    doub N N 79  
ASN   C   OXT  sing N N 80  
ASN   CB  CG   sing N N 81  
ASN   CB  HB2  sing N N 82  
ASN   CB  HB3  sing N N 83  
ASN   CG  OD1  doub N N 84  
ASN   CG  ND2  sing N N 85  
ASN   ND2 HD21 sing N N 86  
ASN   ND2 HD22 sing N N 87  
ASN   OXT HXT  sing N N 88  
ASP   N   CA   sing N N 89  
ASP   N   H    sing N N 90  
ASP   N   H2   sing N N 91  
ASP   CA  C    sing N N 92  
ASP   CA  CB   sing N N 93  
ASP   CA  HA   sing N N 94  
ASP   C   O    doub N N 95  
ASP   C   OXT  sing N N 96  
ASP   CB  CG   sing N N 97  
ASP   CB  HB2  sing N N 98  
ASP   CB  HB3  sing N N 99  
ASP   CG  OD1  doub N N 100 
ASP   CG  OD2  sing N N 101 
ASP   OD2 HD2  sing N N 102 
ASP   OXT HXT  sing N N 103 
CYS   N   CA   sing N N 104 
CYS   N   H    sing N N 105 
CYS   N   H2   sing N N 106 
CYS   CA  C    sing N N 107 
CYS   CA  CB   sing N N 108 
CYS   CA  HA   sing N N 109 
CYS   C   O    doub N N 110 
CYS   C   OXT  sing N N 111 
CYS   CB  SG   sing N N 112 
CYS   CB  HB2  sing N N 113 
CYS   CB  HB3  sing N N 114 
CYS   SG  HG   sing N N 115 
CYS   OXT HXT  sing N N 116 
DMS   S   O    doub N N 117 
DMS   S   C1   sing N N 118 
DMS   S   C2   sing N N 119 
DMS   C1  H11  sing N N 120 
DMS   C1  H12  sing N N 121 
DMS   C1  H13  sing N N 122 
DMS   C2  H21  sing N N 123 
DMS   C2  H22  sing N N 124 
DMS   C2  H23  sing N N 125 
GLN   N   CA   sing N N 126 
GLN   N   H    sing N N 127 
GLN   N   H2   sing N N 128 
GLN   CA  C    sing N N 129 
GLN   CA  CB   sing N N 130 
GLN   CA  HA   sing N N 131 
GLN   C   O    doub N N 132 
GLN   C   OXT  sing N N 133 
GLN   CB  CG   sing N N 134 
GLN   CB  HB2  sing N N 135 
GLN   CB  HB3  sing N N 136 
GLN   CG  CD   sing N N 137 
GLN   CG  HG2  sing N N 138 
GLN   CG  HG3  sing N N 139 
GLN   CD  OE1  doub N N 140 
GLN   CD  NE2  sing N N 141 
GLN   NE2 HE21 sing N N 142 
GLN   NE2 HE22 sing N N 143 
GLN   OXT HXT  sing N N 144 
GLU   N   CA   sing N N 145 
GLU   N   H    sing N N 146 
GLU   N   H2   sing N N 147 
GLU   CA  C    sing N N 148 
GLU   CA  CB   sing N N 149 
GLU   CA  HA   sing N N 150 
GLU   C   O    doub N N 151 
GLU   C   OXT  sing N N 152 
GLU   CB  CG   sing N N 153 
GLU   CB  HB2  sing N N 154 
GLU   CB  HB3  sing N N 155 
GLU   CG  CD   sing N N 156 
GLU   CG  HG2  sing N N 157 
GLU   CG  HG3  sing N N 158 
GLU   CD  OE1  doub N N 159 
GLU   CD  OE2  sing N N 160 
GLU   OE2 HE2  sing N N 161 
GLU   OXT HXT  sing N N 162 
GLY   N   CA   sing N N 163 
GLY   N   H    sing N N 164 
GLY   N   H2   sing N N 165 
GLY   CA  C    sing N N 166 
GLY   CA  HA2  sing N N 167 
GLY   CA  HA3  sing N N 168 
GLY   C   O    doub N N 169 
GLY   C   OXT  sing N N 170 
GLY   OXT HXT  sing N N 171 
HIS   N   CA   sing N N 172 
HIS   N   H    sing N N 173 
HIS   N   H2   sing N N 174 
HIS   CA  C    sing N N 175 
HIS   CA  CB   sing N N 176 
HIS   CA  HA   sing N N 177 
HIS   C   O    doub N N 178 
HIS   C   OXT  sing N N 179 
HIS   CB  CG   sing N N 180 
HIS   CB  HB2  sing N N 181 
HIS   CB  HB3  sing N N 182 
HIS   CG  ND1  sing Y N 183 
HIS   CG  CD2  doub Y N 184 
HIS   ND1 CE1  doub Y N 185 
HIS   ND1 HD1  sing N N 186 
HIS   CD2 NE2  sing Y N 187 
HIS   CD2 HD2  sing N N 188 
HIS   CE1 NE2  sing Y N 189 
HIS   CE1 HE1  sing N N 190 
HIS   NE2 HE2  sing N N 191 
HIS   OXT HXT  sing N N 192 
HOH   O   H1   sing N N 193 
HOH   O   H2   sing N N 194 
ILE   N   CA   sing N N 195 
ILE   N   H    sing N N 196 
ILE   N   H2   sing N N 197 
ILE   CA  C    sing N N 198 
ILE   CA  CB   sing N N 199 
ILE   CA  HA   sing N N 200 
ILE   C   O    doub N N 201 
ILE   C   OXT  sing N N 202 
ILE   CB  CG1  sing N N 203 
ILE   CB  CG2  sing N N 204 
ILE   CB  HB   sing N N 205 
ILE   CG1 CD1  sing N N 206 
ILE   CG1 HG12 sing N N 207 
ILE   CG1 HG13 sing N N 208 
ILE   CG2 HG21 sing N N 209 
ILE   CG2 HG22 sing N N 210 
ILE   CG2 HG23 sing N N 211 
ILE   CD1 HD11 sing N N 212 
ILE   CD1 HD12 sing N N 213 
ILE   CD1 HD13 sing N N 214 
ILE   OXT HXT  sing N N 215 
LEU   N   CA   sing N N 216 
LEU   N   H    sing N N 217 
LEU   N   H2   sing N N 218 
LEU   CA  C    sing N N 219 
LEU   CA  CB   sing N N 220 
LEU   CA  HA   sing N N 221 
LEU   C   O    doub N N 222 
LEU   C   OXT  sing N N 223 
LEU   CB  CG   sing N N 224 
LEU   CB  HB2  sing N N 225 
LEU   CB  HB3  sing N N 226 
LEU   CG  CD1  sing N N 227 
LEU   CG  CD2  sing N N 228 
LEU   CG  HG   sing N N 229 
LEU   CD1 HD11 sing N N 230 
LEU   CD1 HD12 sing N N 231 
LEU   CD1 HD13 sing N N 232 
LEU   CD2 HD21 sing N N 233 
LEU   CD2 HD22 sing N N 234 
LEU   CD2 HD23 sing N N 235 
LEU   OXT HXT  sing N N 236 
LYS   N   CA   sing N N 237 
LYS   N   H    sing N N 238 
LYS   N   H2   sing N N 239 
LYS   CA  C    sing N N 240 
LYS   CA  CB   sing N N 241 
LYS   CA  HA   sing N N 242 
LYS   C   O    doub N N 243 
LYS   C   OXT  sing N N 244 
LYS   CB  CG   sing N N 245 
LYS   CB  HB2  sing N N 246 
LYS   CB  HB3  sing N N 247 
LYS   CG  CD   sing N N 248 
LYS   CG  HG2  sing N N 249 
LYS   CG  HG3  sing N N 250 
LYS   CD  CE   sing N N 251 
LYS   CD  HD2  sing N N 252 
LYS   CD  HD3  sing N N 253 
LYS   CE  NZ   sing N N 254 
LYS   CE  HE2  sing N N 255 
LYS   CE  HE3  sing N N 256 
LYS   NZ  HZ1  sing N N 257 
LYS   NZ  HZ2  sing N N 258 
LYS   NZ  HZ3  sing N N 259 
LYS   OXT HXT  sing N N 260 
MES   O1  C2   sing N N 261 
MES   O1  C6   sing N N 262 
MES   C2  C3   sing N N 263 
MES   C2  H21  sing N N 264 
MES   C2  H22  sing N N 265 
MES   C3  N4   sing N N 266 
MES   C3  H31  sing N N 267 
MES   C3  H32  sing N N 268 
MES   N4  C5   sing N N 269 
MES   N4  C7   sing N N 270 
MES   N4  HN4  sing N N 271 
MES   C5  C6   sing N N 272 
MES   C5  H51  sing N N 273 
MES   C5  H52  sing N N 274 
MES   C6  H61  sing N N 275 
MES   C6  H62  sing N N 276 
MES   C7  C8   sing N N 277 
MES   C7  H71  sing N N 278 
MES   C7  H72  sing N N 279 
MES   C8  S    sing N N 280 
MES   C8  H81  sing N N 281 
MES   C8  H82  sing N N 282 
MES   S   O1S  doub N N 283 
MES   S   O2S  doub N N 284 
MES   S   O3S  sing N N 285 
MET   N   CA   sing N N 286 
MET   N   H    sing N N 287 
MET   N   H2   sing N N 288 
MET   CA  C    sing N N 289 
MET   CA  CB   sing N N 290 
MET   CA  HA   sing N N 291 
MET   C   O    doub N N 292 
MET   C   OXT  sing N N 293 
MET   CB  CG   sing N N 294 
MET   CB  HB2  sing N N 295 
MET   CB  HB3  sing N N 296 
MET   CG  SD   sing N N 297 
MET   CG  HG2  sing N N 298 
MET   CG  HG3  sing N N 299 
MET   SD  CE   sing N N 300 
MET   CE  HE1  sing N N 301 
MET   CE  HE2  sing N N 302 
MET   CE  HE3  sing N N 303 
MET   OXT HXT  sing N N 304 
PEG   C1  O1   sing N N 305 
PEG   C1  C2   sing N N 306 
PEG   C1  H11  sing N N 307 
PEG   C1  H12  sing N N 308 
PEG   O1  HO1  sing N N 309 
PEG   C2  O2   sing N N 310 
PEG   C2  H21  sing N N 311 
PEG   C2  H22  sing N N 312 
PEG   O2  C3   sing N N 313 
PEG   C3  C4   sing N N 314 
PEG   C3  H31  sing N N 315 
PEG   C3  H32  sing N N 316 
PEG   C4  O4   sing N N 317 
PEG   C4  H41  sing N N 318 
PEG   C4  H42  sing N N 319 
PEG   O4  HO4  sing N N 320 
PHE   N   CA   sing N N 321 
PHE   N   H    sing N N 322 
PHE   N   H2   sing N N 323 
PHE   CA  C    sing N N 324 
PHE   CA  CB   sing N N 325 
PHE   CA  HA   sing N N 326 
PHE   C   O    doub N N 327 
PHE   C   OXT  sing N N 328 
PHE   CB  CG   sing N N 329 
PHE   CB  HB2  sing N N 330 
PHE   CB  HB3  sing N N 331 
PHE   CG  CD1  doub Y N 332 
PHE   CG  CD2  sing Y N 333 
PHE   CD1 CE1  sing Y N 334 
PHE   CD1 HD1  sing N N 335 
PHE   CD2 CE2  doub Y N 336 
PHE   CD2 HD2  sing N N 337 
PHE   CE1 CZ   doub Y N 338 
PHE   CE1 HE1  sing N N 339 
PHE   CE2 CZ   sing Y N 340 
PHE   CE2 HE2  sing N N 341 
PHE   CZ  HZ   sing N N 342 
PHE   OXT HXT  sing N N 343 
PO4   P   O1   doub N N 344 
PO4   P   O2   sing N N 345 
PO4   P   O3   sing N N 346 
PO4   P   O4   sing N N 347 
PRO   N   CA   sing N N 348 
PRO   N   CD   sing N N 349 
PRO   N   H    sing N N 350 
PRO   CA  C    sing N N 351 
PRO   CA  CB   sing N N 352 
PRO   CA  HA   sing N N 353 
PRO   C   O    doub N N 354 
PRO   C   OXT  sing N N 355 
PRO   CB  CG   sing N N 356 
PRO   CB  HB2  sing N N 357 
PRO   CB  HB3  sing N N 358 
PRO   CG  CD   sing N N 359 
PRO   CG  HG2  sing N N 360 
PRO   CG  HG3  sing N N 361 
PRO   CD  HD2  sing N N 362 
PRO   CD  HD3  sing N N 363 
PRO   OXT HXT  sing N N 364 
SER   N   CA   sing N N 365 
SER   N   H    sing N N 366 
SER   N   H2   sing N N 367 
SER   CA  C    sing N N 368 
SER   CA  CB   sing N N 369 
SER   CA  HA   sing N N 370 
SER   C   O    doub N N 371 
SER   C   OXT  sing N N 372 
SER   CB  OG   sing N N 373 
SER   CB  HB2  sing N N 374 
SER   CB  HB3  sing N N 375 
SER   OG  HG   sing N N 376 
SER   OXT HXT  sing N N 377 
THR   N   CA   sing N N 378 
THR   N   H    sing N N 379 
THR   N   H2   sing N N 380 
THR   CA  C    sing N N 381 
THR   CA  CB   sing N N 382 
THR   CA  HA   sing N N 383 
THR   C   O    doub N N 384 
THR   C   OXT  sing N N 385 
THR   CB  OG1  sing N N 386 
THR   CB  CG2  sing N N 387 
THR   CB  HB   sing N N 388 
THR   OG1 HG1  sing N N 389 
THR   CG2 HG21 sing N N 390 
THR   CG2 HG22 sing N N 391 
THR   CG2 HG23 sing N N 392 
THR   OXT HXT  sing N N 393 
TRP   N   CA   sing N N 394 
TRP   N   H    sing N N 395 
TRP   N   H2   sing N N 396 
TRP   CA  C    sing N N 397 
TRP   CA  CB   sing N N 398 
TRP   CA  HA   sing N N 399 
TRP   C   O    doub N N 400 
TRP   C   OXT  sing N N 401 
TRP   CB  CG   sing N N 402 
TRP   CB  HB2  sing N N 403 
TRP   CB  HB3  sing N N 404 
TRP   CG  CD1  doub Y N 405 
TRP   CG  CD2  sing Y N 406 
TRP   CD1 NE1  sing Y N 407 
TRP   CD1 HD1  sing N N 408 
TRP   CD2 CE2  doub Y N 409 
TRP   CD2 CE3  sing Y N 410 
TRP   NE1 CE2  sing Y N 411 
TRP   NE1 HE1  sing N N 412 
TRP   CE2 CZ2  sing Y N 413 
TRP   CE3 CZ3  doub Y N 414 
TRP   CE3 HE3  sing N N 415 
TRP   CZ2 CH2  doub Y N 416 
TRP   CZ2 HZ2  sing N N 417 
TRP   CZ3 CH2  sing Y N 418 
TRP   CZ3 HZ3  sing N N 419 
TRP   CH2 HH2  sing N N 420 
TRP   OXT HXT  sing N N 421 
TYR   N   CA   sing N N 422 
TYR   N   H    sing N N 423 
TYR   N   H2   sing N N 424 
TYR   CA  C    sing N N 425 
TYR   CA  CB   sing N N 426 
TYR   CA  HA   sing N N 427 
TYR   C   O    doub N N 428 
TYR   C   OXT  sing N N 429 
TYR   CB  CG   sing N N 430 
TYR   CB  HB2  sing N N 431 
TYR   CB  HB3  sing N N 432 
TYR   CG  CD1  doub Y N 433 
TYR   CG  CD2  sing Y N 434 
TYR   CD1 CE1  sing Y N 435 
TYR   CD1 HD1  sing N N 436 
TYR   CD2 CE2  doub Y N 437 
TYR   CD2 HD2  sing N N 438 
TYR   CE1 CZ   doub Y N 439 
TYR   CE1 HE1  sing N N 440 
TYR   CE2 CZ   sing Y N 441 
TYR   CE2 HE2  sing N N 442 
TYR   CZ  OH   sing N N 443 
TYR   OH  HH   sing N N 444 
TYR   OXT HXT  sing N N 445 
VAL   N   CA   sing N N 446 
VAL   N   H    sing N N 447 
VAL   N   H2   sing N N 448 
VAL   CA  C    sing N N 449 
VAL   CA  CB   sing N N 450 
VAL   CA  HA   sing N N 451 
VAL   C   O    doub N N 452 
VAL   C   OXT  sing N N 453 
VAL   CB  CG1  sing N N 454 
VAL   CB  CG2  sing N N 455 
VAL   CB  HB   sing N N 456 
VAL   CG1 HG11 sing N N 457 
VAL   CG1 HG12 sing N N 458 
VAL   CG1 HG13 sing N N 459 
VAL   CG2 HG21 sing N N 460 
VAL   CG2 HG22 sing N N 461 
VAL   CG2 HG23 sing N N 462 
VAL   OXT HXT  sing N N 463 
# 
_pdbx_audit_support.ordinal                1 
_pdbx_audit_support.funding_organization   
'National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)' 
_pdbx_audit_support.grant_number           U19AI171292 
_pdbx_audit_support.country                'United States' 
# 
_pdbx_deposit_group.group_id            G_1002341 
_pdbx_deposit_group.group_description   
'Crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_pdbx_deposit_group.group_title         
'Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_pdbx_deposit_group.group_type          'changed state' 
# 
_atom_sites.entry_id                    7I2C 
_atom_sites.fract_transf_matrix[1][1]   0.012101 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   -0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.008546 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   -0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.006707 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
# 
loop_
_atom_type.symbol 
C  
CL 
F  
N  
O  
P  
S  
ZN 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . ASN   A 1 10  ? -14.140 -5.998  -13.001 0.50 75.62  ? 273  ASN   A N   1 
ATOM   2    C  CA  . ASN   A 1 10  ? -13.795 -6.803  -11.791 0.50 75.70  ? 273  ASN   A CA  1 
ATOM   3    C  C   . ASN   A 1 10  ? -14.959 -6.718  -10.796 0.50 73.06  ? 273  ASN   A C   1 
ATOM   4    O  O   . ASN   A 1 10  ? -16.026 -7.292  -11.097 0.50 67.49  ? 273  ASN   A O   1 
ATOM   5    C  CB  . ASN   A 1 10  ? -12.468 -6.355  -11.166 0.50 79.00  ? 273  ASN   A CB  1 
ATOM   6    C  CG  . ASN   A 1 10  ? -12.041 -7.204  -9.985  0.50 80.41  ? 273  ASN   A CG  1 
ATOM   7    O  OD1 . ASN   A 1 10  ? -12.779 -8.085  -9.547  0.50 80.29  ? 273  ASN   A OD1 1 
ATOM   8    N  ND2 . ASN   A 1 10  ? -10.855 -6.944  -9.456  0.50 79.02  ? 273  ASN   A ND2 1 
ATOM   9    N  N   . LEU   A 1 11  ? -14.762 -6.017  -9.671  0.50 71.34  ? 274  LEU   A N   1 
ATOM   10   C  CA  . LEU   A 1 11  ? -15.689 -6.016  -8.504  0.50 68.50  ? 274  LEU   A CA  1 
ATOM   11   C  C   . LEU   A 1 11  ? -17.088 -5.577  -8.947  0.50 63.82  ? 274  LEU   A C   1 
ATOM   12   O  O   . LEU   A 1 11  ? -18.057 -5.955  -8.272  0.50 62.56  ? 274  LEU   A O   1 
ATOM   13   C  CB  . LEU   A 1 11  ? -15.138 -5.103  -7.403  0.50 70.72  ? 274  LEU   A CB  1 
ATOM   14   C  CG  . LEU   A 1 11  ? -14.423 -5.822  -6.259  0.50 72.37  ? 274  LEU   A CG  1 
ATOM   15   C  CD1 . LEU   A 1 11  ? -14.011 -4.843  -5.169  0.50 73.46  ? 274  LEU   A CD1 1 
ATOM   16   C  CD2 . LEU   A 1 11  ? -15.300 -6.923  -5.678  0.50 70.91  ? 274  LEU   A CD2 1 
ATOM   17   N  N   . ASP   A 1 12  ? -17.189 -4.823  -10.043 0.50 61.40  ? 275  ASP   A N   1 
ATOM   18   C  CA  . ASP   A 1 12  ? -18.490 -4.403  -10.635 0.50 65.29  ? 275  ASP   A CA  1 
ATOM   19   C  C   . ASP   A 1 12  ? -19.240 -5.642  -11.147 0.50 63.13  ? 275  ASP   A C   1 
ATOM   20   O  O   . ASP   A 1 12  ? -20.486 -5.657  -11.067 0.50 61.42  ? 275  ASP   A O   1 
ATOM   21   C  CB  . ASP   A 1 12  ? -18.289 -3.365  -11.744 0.50 68.25  ? 275  ASP   A CB  1 
ATOM   22   C  CG  . ASP   A 1 12  ? -17.160 -3.696  -12.705 0.50 72.63  ? 275  ASP   A CG  1 
ATOM   23   O  OD1 . ASP   A 1 12  ? -16.280 -4.500  -12.326 0.50 78.29  ? 275  ASP   A OD1 1 
ATOM   24   O  OD2 . ASP   A 1 12  ? -17.171 -3.149  -13.827 0.50 75.16  ? 275  ASP   A OD2 1 
ATOM   25   N  N   . ILE   A 1 13  ? -18.510 -6.647  -11.644 0.50 59.09  ? 276  ILE   A N   1 
ATOM   26   C  CA  . ILE   A 1 13  ? -19.092 -7.858  -12.298 0.50 53.96  ? 276  ILE   A CA  1 
ATOM   27   C  C   . ILE   A 1 13  ? -19.409 -8.913  -11.233 0.50 51.37  ? 276  ILE   A C   1 
ATOM   28   O  O   . ILE   A 1 13  ? -20.470 -9.547  -11.345 0.50 47.79  ? 276  ILE   A O   1 
ATOM   29   C  CB  . ILE   A 1 13  ? -18.150 -8.393  -13.396 0.50 54.47  ? 276  ILE   A CB  1 
ATOM   30   C  CG1 . ILE   A 1 13  ? -18.067 -7.422  -14.578 0.50 52.34  ? 276  ILE   A CG1 1 
ATOM   31   C  CG2 . ILE   A 1 13  ? -18.573 -9.785  -13.838 0.50 54.34  ? 276  ILE   A CG2 1 
ATOM   32   C  CD1 . ILE   A 1 13  ? -17.131 -7.861  -15.679 0.50 52.32  ? 276  ILE   A CD1 1 
ATOM   33   N  N   . ILE   A 1 14  ? -18.538 -9.071  -10.230 0.50 53.62  ? 277  ILE   A N   1 
ATOM   34   C  CA  . ILE   A 1 14  ? -18.639 -10.135 -9.186  0.50 57.16  ? 277  ILE   A CA  1 
ATOM   35   C  C   . ILE   A 1 14  ? -19.241 -9.579  -7.884  0.50 59.48  ? 277  ILE   A C   1 
ATOM   36   O  O   . ILE   A 1 14  ? -19.751 -10.401 -7.089  0.50 60.47  ? 277  ILE   A O   1 
ATOM   37   C  CB  . ILE   A 1 14  ? -17.257 -10.772 -8.937  0.50 59.21  ? 277  ILE   A CB  1 
ATOM   38   C  CG1 . ILE   A 1 14  ? -16.215 -9.719  -8.554  0.50 59.08  ? 277  ILE   A CG1 1 
ATOM   39   C  CG2 . ILE   A 1 14  ? -16.813 -11.590 -10.140 0.50 57.60  ? 277  ILE   A CG2 1 
ATOM   40   C  CD1 . ILE   A 1 14  ? -14.846 -10.291 -8.265  0.50 60.19  ? 277  ILE   A CD1 1 
ATOM   41   N  N   . GLY   A 1 15  ? -19.179 -8.258  -7.664  1.00 65.85  ? 278  GLY   A N   1 
ATOM   42   C  CA  . GLY   A 1 15  ? -19.623 -7.611  -6.398  1.00 63.85  ? 278  GLY   A CA  1 
ATOM   43   C  C   . GLY   A 1 15  ? -21.023 -8.009  -5.954  1.00 66.29  ? 278  GLY   A C   1 
ATOM   44   O  O   . GLY   A 1 15  ? -21.201 -8.421  -4.793  1.00 68.18  ? 278  GLY   A O   1 
ATOM   45   N  N   . LYS   A 1 16  ? -21.998 -7.908  -6.865  0.50 67.93  ? 279  LYS   A N   1 
ATOM   46   C  CA  . LYS   A 1 16  ? -23.436 -8.195  -6.607  0.50 69.51  ? 279  LYS   A CA  1 
ATOM   47   C  C   . LYS   A 1 16  ? -23.578 -9.597  -5.997  0.50 69.98  ? 279  LYS   A C   1 
ATOM   48   O  O   . LYS   A 1 16  ? -24.221 -9.722  -4.933  0.50 66.22  ? 279  LYS   A O   1 
ATOM   49   C  CB  . LYS   A 1 16  ? -24.229 -8.058  -7.911  0.50 73.22  ? 279  LYS   A CB  1 
ATOM   50   C  CG  . LYS   A 1 16  ? -25.745 -8.035  -7.761  0.50 75.65  ? 279  LYS   A CG  1 
ATOM   51   C  CD  . LYS   A 1 16  ? -26.477 -7.834  -9.076  0.50 77.56  ? 279  LYS   A CD  1 
ATOM   52   C  CE  . LYS   A 1 16  ? -27.948 -7.522  -8.902  0.50 78.79  ? 279  LYS   A CE  1 
ATOM   53   N  NZ  . LYS   A 1 16  ? -28.151 -6.233  -8.198  0.50 80.28  ? 279  LYS   A NZ  1 
ATOM   54   N  N   . ARG   A 1 17  ? -22.985 -10.607 -6.642  0.50 67.77  ? 280  ARG   A N   1 
ATOM   55   C  CA  . ARG   A 1 17  ? -23.017 -12.023 -6.187  0.50 68.54  ? 280  ARG   A CA  1 
ATOM   56   C  C   . ARG   A 1 17  ? -22.454 -12.112 -4.765  0.50 67.81  ? 280  ARG   A C   1 
ATOM   57   O  O   . ARG   A 1 17  ? -23.075 -12.784 -3.921  0.50 66.45  ? 280  ARG   A O   1 
ATOM   58   C  CB  . ARG   A 1 17  ? -22.222 -12.912 -7.150  0.50 67.10  ? 280  ARG   A CB  1 
ATOM   59   C  CG  . ARG   A 1 17  ? -23.035 -13.433 -8.325  0.50 65.92  ? 280  ARG   A CG  1 
ATOM   60   C  CD  . ARG   A 1 17  ? -22.169 -14.124 -9.359  0.50 62.75  ? 280  ARG   A CD  1 
ATOM   61   N  NE  . ARG   A 1 17  ? -21.435 -13.172 -10.177 0.50 60.20  ? 280  ARG   A NE  1 
ATOM   62   C  CZ  . ARG   A 1 17  ? -20.596 -13.509 -11.146 0.50 60.25  ? 280  ARG   A CZ  1 
ATOM   63   N  NH1 . ARG   A 1 17  ? -20.378 -14.785 -11.417 0.50 59.43  ? 280  ARG   A NH1 1 
ATOM   64   N  NH2 . ARG   A 1 17  ? -19.983 -12.570 -11.844 0.50 60.53  ? 280  ARG   A NH2 1 
ATOM   65   N  N   . ILE   A 1 18  ? -21.310 -11.468 -4.522  0.50 70.34  ? 281  ILE   A N   1 
ATOM   66   C  CA  . ILE   A 1 18  ? -20.627 -11.447 -3.196  0.50 74.13  ? 281  ILE   A CA  1 
ATOM   67   C  C   . ILE   A 1 18  ? -21.537 -10.709 -2.205  0.50 76.29  ? 281  ILE   A C   1 
ATOM   68   O  O   . ILE   A 1 18  ? -21.970 -11.344 -1.216  0.50 73.47  ? 281  ILE   A O   1 
ATOM   69   C  CB  . ILE   A 1 18  ? -19.230 -10.808 -3.318  0.50 77.22  ? 281  ILE   A CB  1 
ATOM   70   C  CG1 . ILE   A 1 18  ? -18.399 -11.489 -4.407  0.50 79.35  ? 281  ILE   A CG1 1 
ATOM   71   C  CG2 . ILE   A 1 18  ? -18.511 -10.815 -1.979  0.50 77.90  ? 281  ILE   A CG2 1 
ATOM   72   C  CD1 . ILE   A 1 18  ? -17.066 -10.830 -4.662  0.50 80.99  ? 281  ILE   A CD1 1 
ATOM   73   N  N   . GLU   A 1 19  ? -21.846 -9.438  -2.489  0.50 74.79  ? 282  GLU   A N   1 
ATOM   74   C  CA  . GLU   A 1 19  ? -22.774 -8.591  -1.688  0.50 77.38  ? 282  GLU   A CA  1 
ATOM   75   C  C   . GLU   A 1 19  ? -23.922 -9.463  -1.165  0.50 76.07  ? 282  GLU   A C   1 
ATOM   76   O  O   . GLU   A 1 19  ? -24.108 -9.505  0.066   0.50 76.99  ? 282  GLU   A O   1 
ATOM   77   C  CB  . GLU   A 1 19  ? -23.310 -7.424  -2.525  0.50 80.44  ? 282  GLU   A CB  1 
ATOM   78   C  CG  . GLU   A 1 19  ? -22.306 -6.297  -2.731  0.50 82.24  ? 282  GLU   A CG  1 
ATOM   79   C  CD  . GLU   A 1 19  ? -22.658 -5.314  -3.840  0.50 85.03  ? 282  GLU   A CD  1 
ATOM   80   O  OE1 . GLU   A 1 19  ? -23.858 -4.996  -3.996  0.50 88.65  ? 282  GLU   A OE1 1 
ATOM   81   O  OE2 . GLU   A 1 19  ? -21.732 -4.868  -4.554  0.50 83.49  ? 282  GLU   A OE2 1 
ATOM   82   N  N   . LYS   A 1 20  ? -24.646 -10.135 -2.070  1.00 71.64  ? 283  LYS   A N   1 
ATOM   83   C  CA  . LYS   A 1 20  ? -25.844 -10.962 -1.730  1.00 70.71  ? 283  LYS   A CA  1 
ATOM   84   C  C   . LYS   A 1 20  ? -25.515 -12.117 -0.780  1.00 72.07  ? 283  LYS   A C   1 
ATOM   85   O  O   . LYS   A 1 20  ? -26.409 -12.460 0.033   1.00 72.43  ? 283  LYS   A O   1 
ATOM   86   C  CB  . LYS   A 1 20  ? -26.498 -11.546 -2.986  1.00 69.22  ? 283  LYS   A CB  1 
ATOM   87   C  CG  . LYS   A 1 20  ? -27.565 -12.611 -2.742  1.00 66.49  ? 283  LYS   A CG  1 
ATOM   88   C  CD  . LYS   A 1 20  ? -28.398 -12.895 -3.989  1.00 71.38  ? 283  LYS   A CD  1 
ATOM   89   C  CE  . LYS   A 1 20  ? -29.722 -13.591 -3.739  1.00 67.26  ? 283  LYS   A CE  1 
ATOM   90   N  NZ  . LYS   A 1 20  ? -29.537 -15.014 -3.379  1.00 66.07  ? 283  LYS   A NZ  1 
ATOM   91   N  N   . ILE   A 1 21  ? -24.324 -12.717 -0.892  1.00 73.14  ? 284  ILE   A N   1 
ATOM   92   C  CA  . ILE   A 1 21  ? -23.887 -13.831 0.009   1.00 75.90  ? 284  ILE   A CA  1 
ATOM   93   C  C   . ILE   A 1 21  ? -23.560 -13.245 1.391   1.00 70.93  ? 284  ILE   A C   1 
ATOM   94   O  O   . ILE   A 1 21  ? -23.937 -13.877 2.401   1.00 62.89  ? 284  ILE   A O   1 
ATOM   95   C  CB  . ILE   A 1 21  ? -22.686 -14.615 -0.564  1.00 77.89  ? 284  ILE   A CB  1 
ATOM   96   C  CG1 . ILE   A 1 21  ? -23.049 -15.380 -1.841  1.00 82.69  ? 284  ILE   A CG1 1 
ATOM   97   C  CG2 . ILE   A 1 21  ? -22.092 -15.548 0.489   1.00 75.67  ? 284  ILE   A CG2 1 
ATOM   98   C  CD1 . ILE   A 1 21  ? -21.851 -15.709 -2.721  1.00 76.71  ? 284  ILE   A CD1 1 
ATOM   99   N  N   . LYS   A 1 22  ? -22.849 -12.113 1.420   1.00 72.24  ? 285  LYS   A N   1 
ATOM   100  C  CA  . LYS   A 1 22  ? -22.494 -11.359 2.657   1.00 88.05  ? 285  LYS   A CA  1 
ATOM   101  C  C   . LYS   A 1 22  ? -23.730 -11.258 3.569   1.00 84.37  ? 285  LYS   A C   1 
ATOM   102  O  O   . LYS   A 1 22  ? -23.616 -11.613 4.751   1.00 81.92  ? 285  LYS   A O   1 
ATOM   103  C  CB  . LYS   A 1 22  ? -21.938 -9.978  2.291   1.00 93.60  ? 285  LYS   A CB  1 
ATOM   104  C  CG  . LYS   A 1 22  ? -20.816 -9.466  3.183   1.00 98.18  ? 285  LYS   A CG  1 
ATOM   105  C  CD  . LYS   A 1 22  ? -20.292 -8.105  2.780   1.00 103.83 ? 285  LYS   A CD  1 
ATOM   106  C  CE  . LYS   A 1 22  ? -19.342 -7.518  3.806   1.00 115.05 ? 285  LYS   A CE  1 
ATOM   107  N  NZ  . LYS   A 1 22  ? -19.087 -6.078  3.561   1.00 119.69 ? 285  LYS   A NZ  1 
ATOM   108  N  N   . GLN   A 1 23  ? -24.880 -10.858 3.017   1.00 83.68  ? 286  GLN   A N   1 
ATOM   109  C  CA  . GLN   A 1 23  ? -26.127 -10.548 3.770   1.00 86.18  ? 286  GLN   A CA  1 
ATOM   110  C  C   . GLN   A 1 23  ? -26.837 -11.808 4.281   1.00 81.97  ? 286  GLN   A C   1 
ATOM   111  O  O   . GLN   A 1 23  ? -27.462 -11.717 5.344   1.00 95.77  ? 286  GLN   A O   1 
ATOM   112  C  CB  . GLN   A 1 23  ? -27.107 -9.772  2.896   1.00 81.88  ? 286  GLN   A CB  1 
ATOM   113  C  CG  . GLN   A 1 23  ? -26.583 -8.407  2.492   1.00 85.86  ? 286  GLN   A CG  1 
ATOM   114  C  CD  . GLN   A 1 23  ? -27.599 -7.680  1.651   1.00 93.55  ? 286  GLN   A CD  1 
ATOM   115  O  OE1 . GLN   A 1 23  ? -28.805 -7.891  1.787   1.00 101.88 ? 286  GLN   A OE1 1 
ATOM   116  N  NE2 . GLN   A 1 23  ? -27.114 -6.828  0.763   1.00 102.59 ? 286  GLN   A NE2 1 
ATOM   117  N  N   . GLU   A 1 24  ? -26.809 -12.922 3.554   1.00 74.28  ? 287  GLU   A N   1 
ATOM   118  C  CA  . GLU   A 1 24  ? -27.504 -14.165 3.986   1.00 81.48  ? 287  GLU   A CA  1 
ATOM   119  C  C   . GLU   A 1 24  ? -26.767 -14.748 5.202   1.00 83.69  ? 287  GLU   A C   1 
ATOM   120  O  O   . GLU   A 1 24  ? -27.346 -15.633 5.879   1.00 78.93  ? 287  GLU   A O   1 
ATOM   121  C  CB  . GLU   A 1 24  ? -27.582 -15.202 2.856   1.00 82.96  ? 287  GLU   A CB  1 
ATOM   122  C  CG  . GLU   A 1 24  ? -28.332 -14.741 1.612   1.00 88.85  ? 287  GLU   A CG  1 
ATOM   123  C  CD  . GLU   A 1 24  ? -27.907 -15.444 0.327   1.00 89.60  ? 287  GLU   A CD  1 
ATOM   124  O  OE1 . GLU   A 1 24  ? -27.058 -14.876 -0.395  1.00 84.05  ? 287  GLU   A OE1 1 
ATOM   125  O  OE2 . GLU   A 1 24  ? -28.414 -16.560 0.053   1.00 82.26  ? 287  GLU   A OE2 1 
ATOM   126  N  N   . HIS   A 1 25  ? -25.526 -14.304 5.448   1.00 86.63  ? 288  HIS   A N   1 
ATOM   127  C  CA  . HIS   A 1 25  ? -24.657 -14.783 6.559   1.00 93.30  ? 288  HIS   A CA  1 
ATOM   128  C  C   . HIS   A 1 25  ? -23.998 -13.577 7.248   1.00 100.43 ? 288  HIS   A C   1 
ATOM   129  O  O   . HIS   A 1 25  ? -22.801 -13.681 7.613   1.00 103.52 ? 288  HIS   A O   1 
ATOM   130  C  CB  . HIS   A 1 25  ? -23.650 -15.820 6.027   1.00 83.52  ? 288  HIS   A CB  1 
ATOM   131  C  CG  . HIS   A 1 25  ? -24.276 -16.930 5.246   1.00 77.16  ? 288  HIS   A CG  1 
ATOM   132  N  ND1 . HIS   A 1 25  ? -24.834 -18.046 5.854   1.00 80.61  ? 288  HIS   A ND1 1 
ATOM   133  C  CD2 . HIS   A 1 25  ? -24.427 -17.114 3.914   1.00 72.26  ? 288  HIS   A CD2 1 
ATOM   134  C  CE1 . HIS   A 1 25  ? -25.313 -18.860 4.931   1.00 76.45  ? 288  HIS   A CE1 1 
ATOM   135  N  NE2 . HIS   A 1 25  ? -25.077 -18.310 3.732   1.00 66.37  ? 288  HIS   A NE2 1 
ATOM   136  N  N   . GLU   A 1 26  ? -24.768 -12.491 7.430   1.00 103.98 ? 289  GLU   A N   1 
ATOM   137  C  CA  . GLU   A 1 26  ? -24.356 -11.214 8.088   1.00 107.09 ? 289  GLU   A CA  1 
ATOM   138  C  C   . GLU   A 1 26  ? -23.917 -11.493 9.534   1.00 105.85 ? 289  GLU   A C   1 
ATOM   139  O  O   . GLU   A 1 26  ? -23.039 -10.765 10.030  1.00 101.74 ? 289  GLU   A O   1 
ATOM   140  C  CB  . GLU   A 1 26  ? -25.508 -10.200 8.063   1.00 104.53 ? 289  GLU   A CB  1 
ATOM   141  C  CG  . GLU   A 1 26  ? -25.129 -8.786  8.486   1.00 98.05  ? 289  GLU   A CG  1 
ATOM   142  C  CD  . GLU   A 1 26  ? -24.427 -7.944  7.428   1.00 99.54  ? 289  GLU   A CD  1 
ATOM   143  O  OE1 . GLU   A 1 26  ? -23.407 -7.324  7.770   1.00 93.55  ? 289  GLU   A OE1 1 
ATOM   144  O  OE2 . GLU   A 1 26  ? -24.909 -7.889  6.268   1.00 101.81 ? 289  GLU   A OE2 1 
ATOM   145  N  N   . THR   A 1 27  ? -24.509 -12.504 10.180  1.00 108.60 ? 290  THR   A N   1 
ATOM   146  C  CA  . THR   A 1 27  ? -24.151 -12.954 11.553  1.00 117.08 ? 290  THR   A CA  1 
ATOM   147  C  C   . THR   A 1 27  ? -22.677 -13.392 11.599  1.00 117.89 ? 290  THR   A C   1 
ATOM   148  O  O   . THR   A 1 27  ? -22.032 -13.097 12.624  1.00 123.09 ? 290  THR   A O   1 
ATOM   149  C  CB  . THR   A 1 27  ? -25.101 -14.051 12.069  1.00 118.22 ? 290  THR   A CB  1 
ATOM   150  O  OG1 . THR   A 1 27  ? -25.605 -14.812 10.966  1.00 117.65 ? 290  THR   A OG1 1 
ATOM   151  C  CG2 . THR   A 1 27  ? -26.258 -13.492 12.872  1.00 111.61 ? 290  THR   A CG2 1 
ATOM   152  N  N   . SER   A 1 28  ? -22.150 -14.026 10.537  1.00 113.96 ? 291  SER   A N   1 
ATOM   153  C  CA  . SER   A 1 28  ? -20.884 -14.814 10.567  1.00 99.13  ? 291  SER   A CA  1 
ATOM   154  C  C   . SER   A 1 28  ? -19.755 -14.205 9.718   1.00 88.07  ? 291  SER   A C   1 
ATOM   155  O  O   . SER   A 1 28  ? -18.688 -14.838 9.665   1.00 79.45  ? 291  SER   A O   1 
ATOM   156  C  CB  . SER   A 1 28  ? -21.137 -16.232 10.132  1.00 99.68  ? 291  SER   A CB  1 
ATOM   157  O  OG  . SER   A 1 28  ? -22.220 -16.818 10.841  1.00 103.05 ? 291  SER   A OG  1 
ATOM   158  N  N   . TRP   A 1 29  ? -19.940 -13.041 9.088   1.00 83.70  ? 292  TRP   A N   1 
ATOM   159  C  CA  . TRP   A 1 29  ? -18.996 -12.541 8.048   1.00 91.63  ? 292  TRP   A CA  1 
ATOM   160  C  C   . TRP   A 1 29  ? -17.729 -11.963 8.686   1.00 91.79  ? 292  TRP   A C   1 
ATOM   161  O  O   . TRP   A 1 29  ? -17.852 -11.021 9.483   1.00 108.24 ? 292  TRP   A O   1 
ATOM   162  C  CB  . TRP   A 1 29  ? -19.654 -11.518 7.116   1.00 82.94  ? 292  TRP   A CB  1 
ATOM   163  C  CG  . TRP   A 1 29  ? -18.868 -11.242 5.867   1.00 84.81  ? 292  TRP   A CG  1 
ATOM   164  C  CD1 . TRP   A 1 29  ? -18.005 -10.205 5.645   1.00 89.75  ? 292  TRP   A CD1 1 
ATOM   165  C  CD2 . TRP   A 1 29  ? -18.880 -12.018 4.652   1.00 76.32  ? 292  TRP   A CD2 1 
ATOM   166  N  NE1 . TRP   A 1 29  ? -17.486 -10.277 4.378   1.00 85.67  ? 292  TRP   A NE1 1 
ATOM   167  C  CE2 . TRP   A 1 29  ? -18.003 -11.380 3.747   1.00 83.26  ? 292  TRP   A CE2 1 
ATOM   168  C  CE3 . TRP   A 1 29  ? -19.550 -13.175 4.241   1.00 75.90  ? 292  TRP   A CE3 1 
ATOM   169  C  CZ2 . TRP   A 1 29  ? -17.788 -11.864 2.455   1.00 80.33  ? 292  TRP   A CZ2 1 
ATOM   170  C  CZ3 . TRP   A 1 29  ? -19.329 -13.657 2.968   1.00 74.90  ? 292  TRP   A CZ3 1 
ATOM   171  C  CH2 . TRP   A 1 29  ? -18.461 -13.008 2.091   1.00 73.30  ? 292  TRP   A CH2 1 
ATOM   172  N  N   . HIS   A 1 30  ? -16.561 -12.483 8.299   1.00 91.82  ? 293  HIS   A N   1 
ATOM   173  C  CA  . HIS   A 1 30  ? -15.221 -12.007 8.737   1.00 87.76  ? 293  HIS   A CA  1 
ATOM   174  C  C   . HIS   A 1 30  ? -14.199 -12.170 7.613   1.00 88.79  ? 293  HIS   A C   1 
ATOM   175  O  O   . HIS   A 1 30  ? -14.236 -13.214 6.949   1.00 90.52  ? 293  HIS   A O   1 
ATOM   176  C  CB  . HIS   A 1 30  ? -14.745 -12.789 9.967   1.00 88.93  ? 293  HIS   A CB  1 
ATOM   177  C  CG  . HIS   A 1 30  ? -14.712 -14.275 9.805   1.00 75.44  ? 293  HIS   A CG  1 
ATOM   178  N  ND1 . HIS   A 1 30  ? -15.862 -15.041 9.807   1.00 66.07  ? 293  HIS   A ND1 1 
ATOM   179  C  CD2 . HIS   A 1 30  ? -13.678 -15.143 9.722   1.00 74.08  ? 293  HIS   A CD2 1 
ATOM   180  C  CE1 . HIS   A 1 30  ? -15.546 -16.317 9.700   1.00 65.31  ? 293  HIS   A CE1 1 
ATOM   181  N  NE2 . HIS   A 1 30  ? -14.207 -16.409 9.647   1.00 75.16  ? 293  HIS   A NE2 1 
ATOM   182  N  N   . TYR   A 1 31  ? -13.305 -11.193 7.442   1.00 89.47  ? 294  TYR   A N   1 
ATOM   183  C  CA  . TYR   A 1 31  ? -12.080 -11.336 6.617   1.00 94.68  ? 294  TYR   A CA  1 
ATOM   184  C  C   . TYR   A 1 31  ? -11.042 -12.132 7.420   1.00 97.27  ? 294  TYR   A C   1 
ATOM   185  O  O   . TYR   A 1 31  ? -10.117 -11.512 7.977   1.00 107.53 ? 294  TYR   A O   1 
ATOM   186  C  CB  . TYR   A 1 31  ? -11.541 -9.976  6.157   1.00 102.71 ? 294  TYR   A CB  1 
ATOM   187  C  CG  . TYR   A 1 31  ? -10.639 -10.074 4.948   1.00 117.85 ? 294  TYR   A CG  1 
ATOM   188  C  CD1 . TYR   A 1 31  ? -9.454  -10.796 4.993   1.00 123.88 ? 294  TYR   A CD1 1 
ATOM   189  C  CD2 . TYR   A 1 31  ? -10.985 -9.482  3.742   1.00 116.62 ? 294  TYR   A CD2 1 
ATOM   190  C  CE1 . TYR   A 1 31  ? -8.632  -10.916 3.884   1.00 124.16 ? 294  TYR   A CE1 1 
ATOM   191  C  CE2 . TYR   A 1 31  ? -10.171 -9.587  2.625   1.00 122.43 ? 294  TYR   A CE2 1 
ATOM   192  C  CZ  . TYR   A 1 31  ? -8.990  -10.306 2.696   1.00 122.96 ? 294  TYR   A CZ  1 
ATOM   193  O  OH  . TYR   A 1 31  ? -8.182  -10.429 1.604   1.00 121.95 ? 294  TYR   A OH  1 
ATOM   194  N  N   . ASP   A 1 32  ? -11.194 -13.462 7.473   1.00 92.78  ? 295  ASP   A N   1 
ATOM   195  C  CA  . ASP   A 1 32  ? -10.195 -14.414 8.042   1.00 94.60  ? 295  ASP   A CA  1 
ATOM   196  C  C   . ASP   A 1 32  ? -8.804  -14.084 7.474   1.00 104.54 ? 295  ASP   A C   1 
ATOM   197  O  O   . ASP   A 1 32  ? -8.675  -13.931 6.234   1.00 111.95 ? 295  ASP   A O   1 
ATOM   198  C  CB  . ASP   A 1 32  ? -10.582 -15.873 7.769   1.00 83.62  ? 295  ASP   A CB  1 
ATOM   199  C  CG  . ASP   A 1 32  ? -9.682  -16.906 8.422   1.00 80.56  ? 295  ASP   A CG  1 
ATOM   200  O  OD1 . ASP   A 1 32  ? -8.517  -16.583 8.698   1.00 80.83  ? 295  ASP   A OD1 1 
ATOM   201  O  OD2 . ASP   A 1 32  ? -10.159 -18.028 8.648   1.00 78.23  ? 295  ASP   A OD2 1 
ATOM   202  N  N   . GLN   A 1 33  ? -7.808  -13.960 8.358   1.00 96.74  ? 296  GLN   A N   1 
ATOM   203  C  CA  . GLN   A 1 33  ? -6.419  -13.548 8.015   1.00 94.61  ? 296  GLN   A CA  1 
ATOM   204  C  C   . GLN   A 1 33  ? -5.527  -14.773 7.760   1.00 94.22  ? 296  GLN   A C   1 
ATOM   205  O  O   . GLN   A 1 33  ? -4.461  -14.616 7.128   1.00 89.88  ? 296  GLN   A O   1 
ATOM   206  C  CB  . GLN   A 1 33  ? -5.857  -12.640 9.114   1.00 96.74  ? 296  GLN   A CB  1 
ATOM   207  C  CG  . GLN   A 1 33  ? -6.399  -11.216 9.058   1.00 98.68  ? 296  GLN   A CG  1 
ATOM   208  C  CD  . GLN   A 1 33  ? -5.942  -10.471 7.826   1.00 101.39 ? 296  GLN   A CD  1 
ATOM   209  O  OE1 . GLN   A 1 33  ? -5.028  -10.898 7.124   1.00 105.61 ? 296  GLN   A OE1 1 
ATOM   210  N  NE2 . GLN   A 1 33  ? -6.577  -9.343  7.546   1.00 100.83 ? 296  GLN   A NE2 1 
ATOM   211  N  N   . ASP   A 1 34  ? -5.952  -15.948 8.239   0.50 95.04  ? 297  ASP   A N   1 
ATOM   212  C  CA  . ASP   A 1 34  ? -5.250  -17.249 8.057   0.50 98.14  ? 297  ASP   A CA  1 
ATOM   213  C  C   . ASP   A 1 34  ? -5.825  -17.980 6.835   0.50 101.40 ? 297  ASP   A C   1 
ATOM   214  O  O   . ASP   A 1 34  ? -5.954  -19.220 6.904   0.50 103.53 ? 297  ASP   A O   1 
ATOM   215  C  CB  . ASP   A 1 34  ? -5.367  -18.114 9.316   0.50 98.04  ? 297  ASP   A CB  1 
ATOM   216  C  CG  . ASP   A 1 34  ? -4.625  -17.562 10.523  0.50 98.51  ? 297  ASP   A CG  1 
ATOM   217  O  OD1 . ASP   A 1 34  ? -3.552  -16.954 10.329  0.50 98.44  ? 297  ASP   A OD1 1 
ATOM   218  O  OD2 . ASP   A 1 34  ? -5.126  -17.746 11.651  0.50 95.81  ? 297  ASP   A OD2 1 
ATOM   219  N  N   . HIS   A 1 35  ? -6.146  -17.246 5.761   1.00 103.86 ? 298  HIS   A N   1 
ATOM   220  C  CA  . HIS   A 1 35  ? -6.738  -17.814 4.512   1.00 94.91  ? 298  HIS   A CA  1 
ATOM   221  C  C   . HIS   A 1 35  ? -5.628  -18.447 3.670   1.00 92.34  ? 298  HIS   A C   1 
ATOM   222  O  O   . HIS   A 1 35  ? -4.610  -17.807 3.410   1.00 97.45  ? 298  HIS   A O   1 
ATOM   223  C  CB  . HIS   A 1 35  ? -7.599  -16.769 3.773   1.00 87.46  ? 298  HIS   A CB  1 
ATOM   224  C  CG  . HIS   A 1 35  ? -6.876  -15.733 2.968   1.00 84.97  ? 298  HIS   A CG  1 
ATOM   225  N  ND1 . HIS   A 1 35  ? -6.931  -14.379 3.280   1.00 84.74  ? 298  HIS   A ND1 1 
ATOM   226  C  CD2 . HIS   A 1 35  ? -6.159  -15.818 1.824   1.00 77.91  ? 298  HIS   A CD2 1 
ATOM   227  C  CE1 . HIS   A 1 35  ? -6.252  -13.687 2.387   1.00 77.74  ? 298  HIS   A CE1 1 
ATOM   228  N  NE2 . HIS   A 1 35  ? -5.761  -14.548 1.487   1.00 82.44  ? 298  HIS   A NE2 1 
ATOM   229  N  N   . PRO   A 1 36  ? -5.778  -19.723 3.233   1.00 83.22  ? 299  PRO   A N   1 
ATOM   230  C  CA  . PRO   A 1 36  ? -4.711  -20.435 2.524   1.00 79.80  ? 299  PRO   A CA  1 
ATOM   231  C  C   . PRO   A 1 36  ? -4.540  -20.175 1.018   1.00 82.21  ? 299  PRO   A C   1 
ATOM   232  O  O   . PRO   A 1 36  ? -3.835  -20.943 0.396   1.00 86.08  ? 299  PRO   A O   1 
ATOM   233  C  CB  . PRO   A 1 36  ? -5.151  -21.897 2.688   1.00 79.00  ? 299  PRO   A CB  1 
ATOM   234  C  CG  . PRO   A 1 36  ? -6.658  -21.825 2.662   1.00 79.61  ? 299  PRO   A CG  1 
ATOM   235  C  CD  . PRO   A 1 36  ? -6.971  -20.565 3.434   1.00 82.35  ? 299  PRO   A CD  1 
ATOM   236  N  N   . TYR   A 1 37  ? -5.177  -19.140 0.461   1.00 84.72  ? 300  TYR   A N   1 
ATOM   237  C  CA  . TYR   A 1 37  ? -5.250  -18.904 -1.006  1.00 76.61  ? 300  TYR   A CA  1 
ATOM   238  C  C   . TYR   A 1 37  ? -4.084  -18.012 -1.410  1.00 76.04  ? 300  TYR   A C   1 
ATOM   239  O  O   . TYR   A 1 37  ? -3.765  -17.091 -0.648  1.00 81.91  ? 300  TYR   A O   1 
ATOM   240  C  CB  . TYR   A 1 37  ? -6.616  -18.333 -1.408  1.00 74.23  ? 300  TYR   A CB  1 
ATOM   241  C  CG  . TYR   A 1 37  ? -7.754  -19.197 -0.934  1.00 64.47  ? 300  TYR   A CG  1 
ATOM   242  C  CD1 . TYR   A 1 37  ? -7.862  -20.508 -1.364  1.00 70.89  ? 300  TYR   A CD1 1 
ATOM   243  C  CD2 . TYR   A 1 37  ? -8.661  -18.755 0.008   1.00 58.40  ? 300  TYR   A CD2 1 
ATOM   244  C  CE1 . TYR   A 1 37  ? -8.859  -21.351 -0.902  1.00 62.04  ? 300  TYR   A CE1 1 
ATOM   245  C  CE2 . TYR   A 1 37  ? -9.661  -19.585 0.487   1.00 57.83  ? 300  TYR   A CE2 1 
ATOM   246  C  CZ  . TYR   A 1 37  ? -9.767  -20.881 0.023   1.00 58.28  ? 300  TYR   A CZ  1 
ATOM   247  O  OH  . TYR   A 1 37  ? -10.729 -21.733 0.464   1.00 67.67  ? 300  TYR   A OH  1 
ATOM   248  N  N   . LYS   A 1 38  ? -3.471  -18.313 -2.559  1.00 76.35  ? 301  LYS   A N   1 
ATOM   249  C  CA  . LYS   A 1 38  ? -2.437  -17.463 -3.202  1.00 72.73  ? 301  LYS   A CA  1 
ATOM   250  C  C   . LYS   A 1 38  ? -2.913  -16.915 -4.556  1.00 74.51  ? 301  LYS   A C   1 
ATOM   251  O  O   . LYS   A 1 38  ? -2.846  -15.688 -4.761  1.00 70.62  ? 301  LYS   A O   1 
ATOM   252  C  CB  . LYS   A 1 38  ? -1.117  -18.217 -3.392  1.00 77.72  ? 301  LYS   A CB  1 
ATOM   253  C  CG  . LYS   A 1 38  ? 0.078   -17.323 -3.731  1.00 86.39  ? 301  LYS   A CG  1 
ATOM   254  C  CD  . LYS   A 1 38  ? 0.184   -16.054 -2.877  1.00 82.58  ? 301  LYS   A CD  1 
ATOM   255  C  CE  . LYS   A 1 38  ? 1.245   -15.080 -3.349  1.00 91.85  ? 301  LYS   A CE  1 
ATOM   256  N  NZ  . LYS   A 1 38  ? 2.379   -14.973 -2.396  1.00 94.53  ? 301  LYS   A NZ  1 
ATOM   257  N  N   . THR   A 1 39  ? -3.395  -17.796 -5.442  0.50 71.09  ? 302  THR   A N   1 
ATOM   258  C  CA  . THR   A 1 39  ? -3.808  -17.461 -6.833  0.50 68.06  ? 302  THR   A CA  1 
ATOM   259  C  C   . THR   A 1 39  ? -5.301  -17.113 -6.878  0.50 64.66  ? 302  THR   A C   1 
ATOM   260  O  O   . THR   A 1 39  ? -5.707  -16.405 -7.816  0.50 63.74  ? 302  THR   A O   1 
ATOM   261  C  CB  . THR   A 1 39  ? -3.489  -18.614 -7.788  0.50 67.43  ? 302  THR   A CB  1 
ATOM   262  O  OG1 . THR   A 1 39  ? -4.431  -19.653 -7.523  0.50 66.83  ? 302  THR   A OG1 1 
ATOM   263  C  CG2 . THR   A 1 39  ? -2.074  -19.129 -7.631  0.50 68.92  ? 302  THR   A CG2 1 
ATOM   264  N  N   . TRP   A 1 40  ? -6.084  -17.609 -5.915  0.50 63.12  ? 303  TRP   A N   1 
ATOM   265  C  CA  . TRP   A 1 40  ? -7.539  -17.329 -5.786  0.50 62.39  ? 303  TRP   A CA  1 
ATOM   266  C  C   . TRP   A 1 40  ? -7.748  -16.062 -4.951  0.50 63.86  ? 303  TRP   A C   1 
ATOM   267  O  O   . TRP   A 1 40  ? -7.394  -16.085 -3.755  0.50 58.13  ? 303  TRP   A O   1 
ATOM   268  C  CB  . TRP   A 1 40  ? -8.267  -18.522 -5.161  0.50 63.03  ? 303  TRP   A CB  1 
ATOM   269  C  CG  . TRP   A 1 40  ? -8.499  -19.657 -6.107  0.50 63.21  ? 303  TRP   A CG  1 
ATOM   270  C  CD1 . TRP   A 1 40  ? -7.622  -20.647 -6.435  0.50 64.32  ? 303  TRP   A CD1 1 
ATOM   271  C  CD2 . TRP   A 1 40  ? -9.702  -19.926 -6.846  0.50 63.60  ? 303  TRP   A CD2 1 
ATOM   272  N  NE1 . TRP   A 1 40  ? -8.194  -21.512 -7.327  0.50 66.54  ? 303  TRP   A NE1 1 
ATOM   273  C  CE2 . TRP   A 1 40  ? -9.470  -21.095 -7.599  0.50 64.34  ? 303  TRP   A CE2 1 
ATOM   274  C  CE3 . TRP   A 1 40  ? -10.946 -19.295 -6.946  0.50 63.84  ? 303  TRP   A CE3 1 
ATOM   275  C  CZ2 . TRP   A 1 40  ? -10.437 -21.644 -8.438  0.50 63.60  ? 303  TRP   A CZ2 1 
ATOM   276  C  CZ3 . TRP   A 1 40  ? -11.901 -19.838 -7.777  0.50 66.07  ? 303  TRP   A CZ3 1 
ATOM   277  C  CH2 . TRP   A 1 40  ? -11.649 -20.998 -8.509  0.50 64.00  ? 303  TRP   A CH2 1 
ATOM   278  N  N   . ALA   A 1 41  ? -8.406  -15.056 -5.534  0.50 64.41  ? 304  ALA   A N   1 
ATOM   279  C  CA  . ALA   A 1 41  ? -8.750  -13.829 -4.781  0.50 65.93  ? 304  ALA   A CA  1 
ATOM   280  C  C   . ALA   A 1 41  ? -9.769  -14.173 -3.692  0.50 68.23  ? 304  ALA   A C   1 
ATOM   281  O  O   . ALA   A 1 41  ? -10.821 -14.741 -4.028  0.50 66.66  ? 304  ALA   A O   1 
ATOM   282  C  CB  . ALA   A 1 41  ? -9.282  -12.782 -5.723  0.50 64.99  ? 304  ALA   A CB  1 
ATOM   283  N  N   . TYR   A 1 42  ? -9.459  -13.837 -2.438  1.00 72.81  ? 305  TYR   A N   1 
ATOM   284  C  CA  . TYR   A 1 42  ? -10.342 -14.144 -1.287  1.00 71.09  ? 305  TYR   A CA  1 
ATOM   285  C  C   . TYR   A 1 42  ? -11.216 -12.926 -1.016  1.00 69.48  ? 305  TYR   A C   1 
ATOM   286  O  O   . TYR   A 1 42  ? -10.794 -11.800 -1.325  1.00 76.10  ? 305  TYR   A O   1 
ATOM   287  C  CB  . TYR   A 1 42  ? -9.483  -14.487 -0.070  1.00 73.62  ? 305  TYR   A CB  1 
ATOM   288  C  CG  . TYR   A 1 42  ? -10.198 -14.694 1.238   1.00 71.72  ? 305  TYR   A CG  1 
ATOM   289  C  CD1 . TYR   A 1 42  ? -10.966 -15.821 1.463   1.00 64.59  ? 305  TYR   A CD1 1 
ATOM   290  C  CD2 . TYR   A 1 42  ? -10.053 -13.788 2.275   1.00 72.87  ? 305  TYR   A CD2 1 
ATOM   291  C  CE1 . TYR   A 1 42  ? -11.605 -16.025 2.674   1.00 71.47  ? 305  TYR   A CE1 1 
ATOM   292  C  CE2 . TYR   A 1 42  ? -10.681 -13.978 3.493   1.00 69.17  ? 305  TYR   A CE2 1 
ATOM   293  C  CZ  . TYR   A 1 42  ? -11.461 -15.102 3.692   1.00 70.11  ? 305  TYR   A CZ  1 
ATOM   294  O  OH  . TYR   A 1 42  ? -12.087 -15.295 4.887   1.00 69.77  ? 305  TYR   A OH  1 
ATOM   295  N  N   . HIS   A 1 43  ? -12.402 -13.154 -0.468  1.00 68.38  ? 306  HIS   A N   1 
ATOM   296  C  CA  . HIS   A 1 43  ? -13.341 -12.028 -0.264  1.00 70.87  ? 306  HIS   A CA  1 
ATOM   297  C  C   . HIS   A 1 43  ? -13.890 -12.074 1.163   1.00 70.40  ? 306  HIS   A C   1 
ATOM   298  O  O   . HIS   A 1 43  ? -14.125 -11.000 1.729   1.00 87.10  ? 306  HIS   A O   1 
ATOM   299  C  CB  . HIS   A 1 43  ? -14.436 -12.070 -1.335  1.00 68.94  ? 306  HIS   A CB  1 
ATOM   300  C  CG  . HIS   A 1 43  ? -13.941 -11.883 -2.727  1.00 62.85  ? 306  HIS   A CG  1 
ATOM   301  N  ND1 . HIS   A 1 43  ? -13.675 -10.638 -3.252  1.00 59.15  ? 306  HIS   A ND1 1 
ATOM   302  C  CD2 . HIS   A 1 43  ? -13.677 -12.773 -3.706  1.00 59.75  ? 306  HIS   A CD2 1 
ATOM   303  C  CE1 . HIS   A 1 43  ? -13.260 -10.767 -4.493  1.00 58.80  ? 306  HIS   A CE1 1 
ATOM   304  N  NE2 . HIS   A 1 43  ? -13.253 -12.066 -4.794  1.00 56.42  ? 306  HIS   A NE2 1 
ATOM   305  N  N   . GLY   A 1 44  ? -14.092 -13.271 1.706   1.00 68.98  ? 307  GLY   A N   1 
ATOM   306  C  CA  . GLY   A 1 44  ? -14.680 -13.389 3.049   1.00 70.71  ? 307  GLY   A CA  1 
ATOM   307  C  C   . GLY   A 1 44  ? -15.050 -14.808 3.411   1.00 70.17  ? 307  GLY   A C   1 
ATOM   308  O  O   . GLY   A 1 44  ? -14.975 -15.673 2.535   1.00 65.72  ? 307  GLY   A O   1 
ATOM   309  N  N   . SER   A 1 45  ? -15.437 -15.028 4.667   0.50 72.02  ? 308  SER   A N   1 
ATOM   310  C  CA  . SER   A 1 45  ? -15.840 -16.373 5.157   0.50 74.02  ? 308  SER   A CA  1 
ATOM   311  C  C   . SER   A 1 45  ? -17.190 -16.277 5.877   0.50 75.12  ? 308  SER   A C   1 
ATOM   312  O  O   . SER   A 1 45  ? -17.725 -15.153 5.980   0.50 75.37  ? 308  SER   A O   1 
ATOM   313  C  CB  . SER   A 1 45  ? -14.783 -16.962 6.057   0.50 76.60  ? 308  SER   A CB  1 
ATOM   314  O  OG  . SER   A 1 45  ? -13.557 -17.127 5.359   0.50 78.63  ? 308  SER   A OG  1 
ATOM   315  N  N   . TYR   A 1 46  ? -17.714 -17.420 6.336   0.50 75.24  ? 309  TYR   A N   1 
ATOM   316  C  CA  . TYR   A 1 46  ? -18.981 -17.551 7.105   0.50 76.46  ? 309  TYR   A CA  1 
ATOM   317  C  C   . TYR   A 1 46  ? -19.172 -19.023 7.503   0.50 76.69  ? 309  TYR   A C   1 
ATOM   318  O  O   . TYR   A 1 46  ? -18.764 -19.918 6.736   0.50 76.45  ? 309  TYR   A O   1 
ATOM   319  C  CB  . TYR   A 1 46  ? -20.156 -16.971 6.308   0.50 76.26  ? 309  TYR   A CB  1 
ATOM   320  C  CG  . TYR   A 1 46  ? -20.705 -17.840 5.202   0.50 75.99  ? 309  TYR   A CG  1 
ATOM   321  C  CD1 . TYR   A 1 46  ? -21.527 -18.918 5.485   0.50 75.89  ? 309  TYR   A CD1 1 
ATOM   322  C  CD2 . TYR   A 1 46  ? -20.443 -17.563 3.870   0.50 75.64  ? 309  TYR   A CD2 1 
ATOM   323  C  CE1 . TYR   A 1 46  ? -22.050 -19.714 4.479   0.50 75.85  ? 309  TYR   A CE1 1 
ATOM   324  C  CE2 . TYR   A 1 46  ? -20.957 -18.349 2.850   0.50 74.82  ? 309  TYR   A CE2 1 
ATOM   325  C  CZ  . TYR   A 1 46  ? -21.765 -19.429 3.156   0.50 74.56  ? 309  TYR   A CZ  1 
ATOM   326  O  OH  . TYR   A 1 46  ? -22.284 -20.213 2.167   0.50 72.21  ? 309  TYR   A OH  1 
ATOM   327  N  N   . GLU   A 1 47  ? -19.751 -19.259 8.685   0.50 76.67  ? 310  GLU   A N   1 
ATOM   328  C  CA  . GLU   A 1 47  ? -19.906 -20.606 9.303   0.50 78.62  ? 310  GLU   A CA  1 
ATOM   329  C  C   . GLU   A 1 47  ? -20.939 -21.407 8.505   0.50 77.75  ? 310  GLU   A C   1 
ATOM   330  O  O   . GLU   A 1 47  ? -21.876 -20.783 7.972   0.50 78.29  ? 310  GLU   A O   1 
ATOM   331  C  CB  . GLU   A 1 47  ? -20.311 -20.479 10.776  0.50 81.22  ? 310  GLU   A CB  1 
ATOM   332  C  CG  . GLU   A 1 47  ? -20.644 -21.810 11.439  0.50 80.21  ? 310  GLU   A CG  1 
ATOM   333  C  CD  . GLU   A 1 47  ? -20.325 -21.907 12.924  0.50 78.03  ? 310  GLU   A CD  1 
ATOM   334  O  OE1 . GLU   A 1 47  ? -20.558 -22.990 13.506  0.50 74.58  ? 310  GLU   A OE1 1 
ATOM   335  O  OE2 . GLU   A 1 47  ? -19.837 -20.908 13.495  0.50 72.19  ? 310  GLU   A OE2 1 
ATOM   336  N  N   . THR   A 1 48  ? -20.763 -22.732 8.433   0.50 77.11  ? 311  THR   A N   1 
ATOM   337  C  CA  . THR   A 1 48  ? -21.637 -23.674 7.679   0.50 78.34  ? 311  THR   A CA  1 
ATOM   338  C  C   . THR   A 1 48  ? -21.710 -25.011 8.424   0.50 79.96  ? 311  THR   A C   1 
ATOM   339  O  O   . THR   A 1 48  ? -20.669 -25.396 8.993   0.50 85.91  ? 311  THR   A O   1 
ATOM   340  C  CB  . THR   A 1 48  ? -21.134 -23.869 6.242   0.50 79.10  ? 311  THR   A CB  1 
ATOM   341  O  OG1 . THR   A 1 48  ? -19.719 -24.057 6.287   0.50 81.08  ? 311  THR   A OG1 1 
ATOM   342  C  CG2 . THR   A 1 48  ? -21.456 -22.701 5.336   0.50 79.10  ? 311  THR   A CG2 1 
ATOM   343  N  N   . SER   A 1 55  ? -19.297 -41.283 0.107   0.50 63.10  ? 318  SER   A N   1 
ATOM   344  C  CA  . SER   A 1 55  ? -18.308 -42.390 0.021   0.50 58.88  ? 318  SER   A CA  1 
ATOM   345  C  C   . SER   A 1 55  ? -18.796 -43.446 -0.980  0.50 54.16  ? 318  SER   A C   1 
ATOM   346  O  O   . SER   A 1 55  ? -20.012 -43.498 -1.248  0.50 52.18  ? 318  SER   A O   1 
ATOM   347  C  CB  . SER   A 1 55  ? -18.053 -42.992 1.382   0.50 59.78  ? 318  SER   A CB  1 
ATOM   348  O  OG  . SER   A 1 55  ? -19.028 -43.978 1.703   0.50 56.94  ? 318  SER   A OG  1 
ATOM   349  N  N   . SER   A 1 56  ? -17.874 -44.252 -1.510  0.50 50.80  ? 319  SER   A N   1 
ATOM   350  C  CA  . SER   A 1 56  ? -18.171 -45.381 -2.428  0.50 49.01  ? 319  SER   A CA  1 
ATOM   351  C  C   . SER   A 1 56  ? -18.769 -46.536 -1.620  0.50 47.01  ? 319  SER   A C   1 
ATOM   352  O  O   . SER   A 1 56  ? -18.139 -46.961 -0.628  0.50 47.18  ? 319  SER   A O   1 
ATOM   353  C  CB  . SER   A 1 56  ? -16.941 -45.808 -3.192  0.50 52.49  ? 319  SER   A CB  1 
ATOM   354  O  OG  . SER   A 1 56  ? -15.844 -46.030 -2.323  0.50 53.27  ? 319  SER   A OG  1 
ATOM   355  N  N   . MET   A 1 57  ? -19.949 -47.016 -2.024  0.50 42.19  ? 320  MET   A N   1 
ATOM   356  C  CA  . MET   A 1 57  ? -20.632 -48.171 -1.383  0.50 37.59  ? 320  MET   A CA  1 
ATOM   357  C  C   . MET   A 1 57  ? -20.459 -49.411 -2.269  0.50 32.62  ? 320  MET   A C   1 
ATOM   358  O  O   . MET   A 1 57  ? -20.354 -49.249 -3.494  0.50 32.30  ? 320  MET   A O   1 
ATOM   359  C  CB  . MET   A 1 57  ? -22.116 -47.857 -1.206  0.50 40.14  ? 320  MET   A CB  1 
ATOM   360  C  CG  . MET   A 1 57  ? -22.352 -46.458 -0.656  0.50 41.87  ? 320  MET   A CG  1 
ATOM   361  S  SD  . MET   A 1 57  ? -21.693 -46.283 1.022   0.50 45.71  ? 320  MET   A SD  1 
ATOM   362  C  CE  . MET   A 1 57  ? -22.822 -47.347 1.917   0.50 43.72  ? 320  MET   A CE  1 
ATOM   363  N  N   . VAL   A 1 58  ? -20.420 -50.600 -1.672  1.00 29.63  ? 321  VAL   A N   1 
ATOM   364  C  CA  . VAL   A 1 58  ? -20.241 -51.856 -2.439  1.00 29.06  ? 321  VAL   A CA  1 
ATOM   365  C  C   . VAL   A 1 58  ? -21.581 -52.358 -2.988  1.00 27.34  ? 321  VAL   A C   1 
ATOM   366  O  O   . VAL   A 1 58  ? -22.539 -52.334 -2.250  1.00 28.87  ? 321  VAL   A O   1 
ATOM   367  C  CB  . VAL   A 1 58  ? -19.484 -52.916 -1.650  1.00 30.38  ? 321  VAL   A CB  1 
ATOM   368  C  CG1 . VAL   A 1 58  ? -19.387 -54.198 -2.469  1.00 28.34  ? 321  VAL   A CG1 1 
ATOM   369  C  CG2 . VAL   A 1 58  ? -18.094 -52.396 -1.313  1.00 33.92  ? 321  VAL   A CG2 1 
ATOM   370  N  N   . ASN   A 1 59  ? -21.604 -52.761 -4.263  1.00 22.88  ? 322  ASN   A N   1 
ATOM   371  C  CA  . ASN   A 1 59  ? -22.703 -53.494 -4.924  1.00 23.30  ? 322  ASN   A CA  1 
ATOM   372  C  C   . ASN   A 1 59  ? -22.605 -54.990 -4.562  1.00 24.93  ? 322  ASN   A C   1 
ATOM   373  O  O   . ASN   A 1 59  ? -21.815 -55.715 -5.177  1.00 24.34  ? 322  ASN   A O   1 
ATOM   374  C  CB  . ASN   A 1 59  ? -22.698 -53.247 -6.436  1.00 25.40  ? 322  ASN   A CB  1 
ATOM   375  C  CG  . ASN   A 1 59  ? -23.913 -53.849 -7.122  1.00 25.05  ? 322  ASN   A CG  1 
ATOM   376  O  OD1 . ASN   A 1 59  ? -24.370 -54.922 -6.755  1.00 22.28  ? 322  ASN   A OD1 1 
ATOM   377  N  ND2 . ASN   A 1 59  ? -24.465 -53.161 -8.114  1.00 30.23  ? 322  ASN   A ND2 1 
ATOM   378  N  N   . GLY   A 1 60  ? -23.471 -55.450 -3.668  1.00 24.59  ? 323  GLY   A N   1 
ATOM   379  C  CA  . GLY   A 1 60  ? -23.486 -56.835 -3.159  1.00 22.42  ? 323  GLY   A CA  1 
ATOM   380  C  C   . GLY   A 1 60  ? -23.847 -57.869 -4.189  1.00 25.41  ? 323  GLY   A C   1 
ATOM   381  O  O   . GLY   A 1 60  ? -23.330 -58.979 -4.101  1.00 25.71  ? 323  GLY   A O   1 
ATOM   382  N  N   . VAL   A 1 61  ? -24.717 -57.537 -5.151  1.00 22.99  ? 324  VAL   A N   1 
ATOM   383  C  CA  . VAL   A 1 61  ? -25.033 -58.465 -6.232  1.00 23.56  ? 324  VAL   A CA  1 
ATOM   384  C  C   . VAL   A 1 61  ? -23.787 -58.712 -7.056  1.00 22.98  ? 324  VAL   A C   1 
ATOM   385  O  O   . VAL   A 1 61  ? -23.495 -59.901 -7.295  1.00 20.86  ? 324  VAL   A O   1 
ATOM   386  C  CB  . VAL   A 1 61  ? -26.213 -57.969 -7.080  1.00 24.28  ? 324  VAL   A CB  1 
ATOM   387  C  CG1 . VAL   A 1 61  ? -26.351 -58.759 -8.328  1.00 23.92  ? 324  VAL   A CG1 1 
ATOM   388  C  CG2 . VAL   A 1 61  ? -27.492 -57.961 -6.250  1.00 29.56  ? 324  VAL   A CG2 1 
ATOM   389  N  N   . VAL   A 1 62  ? -23.068 -57.671 -7.508  1.00 21.15  ? 325  VAL   A N   1 
ATOM   390  C  CA  . VAL   A 1 62  ? -21.857 -57.932 -8.355  1.00 21.18  ? 325  VAL   A CA  1 
ATOM   391  C  C   . VAL   A 1 62  ? -20.749 -58.636 -7.523  1.00 20.40  ? 325  VAL   A C   1 
ATOM   392  O  O   . VAL   A 1 62  ? -20.151 -59.615 -7.993  1.00 22.33  ? 325  VAL   A O   1 
ATOM   393  C  CB  . VAL   A 1 62  ? -21.375 -56.641 -9.043  1.00 22.50  ? 325  VAL   A CB  1 
ATOM   394  C  CG1 . VAL   A 1 62  ? -20.097 -56.891 -9.829  1.00 20.13  ? 325  VAL   A CG1 1 
ATOM   395  C  CG2 . VAL   A 1 62  ? -22.430 -56.030 -9.935  1.00 23.70  ? 325  VAL   A CG2 1 
ATOM   396  N  N   . ARG   A 1 63  ? -20.546 -58.246 -6.275  1.00 22.30  ? 326  ARG   A N   1 
ATOM   397  C  CA  . ARG   A 1 63  ? -19.469 -58.819 -5.438  1.00 22.87  ? 326  ARG   A CA  1 
ATOM   398  C  C   . ARG   A 1 63  ? -19.745 -60.290 -5.146  1.00 23.43  ? 326  ARG   A C   1 
ATOM   399  O  O   . ARG   A 1 63  ? -18.804 -61.113 -5.316  1.00 21.84  ? 326  ARG   A O   1 
ATOM   400  C  CB  . ARG   A 1 63  ? -19.279 -58.062 -4.142  1.00 22.80  ? 326  ARG   A CB  1 
ATOM   401  C  CG  . ARG   A 1 63  ? -18.167 -58.666 -3.279  1.00 23.12  ? 326  ARG   A CG  1 
ATOM   402  C  CD  . ARG   A 1 63  ? -17.453 -57.705 -2.334  1.00 21.14  ? 326  ARG   A CD  1 
ATOM   403  N  NE  . ARG   A 1 63  ? -18.346 -57.256 -1.278  1.00 22.20  ? 326  ARG   A NE  1 
ATOM   404  C  CZ  . ARG   A 1 63  ? -18.019 -56.489 -0.266  1.00 21.67  ? 326  ARG   A CZ  1 
ATOM   405  N  NH1 . ARG   A 1 63  ? -16.770 -56.114 -0.116  1.00 22.42  ? 326  ARG   A NH1 1 
ATOM   406  N  NH2 . ARG   A 1 63  ? -18.935 -56.062 0.595   1.00 23.81  ? 326  ARG   A NH2 1 
ATOM   407  N  N   . LEU   A 1 64  ? -20.989 -60.673 -4.847  1.00 22.99  ? 327  LEU   A N   1 
ATOM   408  C  CA  . LEU   A 1 64  ? -21.260 -62.110 -4.560  1.00 22.33  ? 327  LEU   A CA  1 
ATOM   409  C  C   . LEU   A 1 64  ? -21.022 -62.966 -5.814  1.00 21.60  ? 327  LEU   A C   1 
ATOM   410  O  O   . LEU   A 1 64  ? -20.720 -64.154 -5.686  1.00 24.45  ? 327  LEU   A O   1 
ATOM   411  C  CB  . LEU   A 1 64  ? -22.717 -62.265 -4.076  1.00 24.64  ? 327  LEU   A CB  1 
ATOM   412  C  CG  . LEU   A 1 64  ? -22.971 -61.968 -2.599  1.00 25.14  ? 327  LEU   A CG  1 
ATOM   413  C  CD1 . LEU   A 1 64  ? -24.481 -62.147 -2.253  1.00 24.13  ? 327  LEU   A CD1 1 
ATOM   414  C  CD2 . LEU   A 1 64  ? -22.122 -62.840 -1.676  1.00 27.03  ? 327  LEU   A CD2 1 
ATOM   415  N  N   . LEU   A 1 65  ? -21.135 -62.408 -7.019  1.00 20.86  ? 328  LEU   A N   1 
ATOM   416  C  CA  . LEU   A 1 65  ? -20.892 -63.183 -8.283  1.00 22.69  ? 328  LEU   A CA  1 
ATOM   417  C  C   . LEU   A 1 65  ? -19.470 -63.000 -8.845  1.00 20.65  ? 328  LEU   A C   1 
ATOM   418  O  O   . LEU   A 1 65  ? -19.215 -63.529 -9.929  1.00 23.02  ? 328  LEU   A O   1 
ATOM   419  C  CB  . LEU   A 1 65  ? -21.972 -62.765 -9.285  1.00 23.05  ? 328  LEU   A CB  1 
ATOM   420  C  CG  . LEU   A 1 65  ? -23.386 -63.159 -8.807  1.00 23.77  ? 328  LEU   A CG  1 
ATOM   421  C  CD1 . LEU   A 1 65  ? -24.500 -62.550 -9.667  1.00 24.73  ? 328  LEU   A CD1 1 
ATOM   422  C  CD2 . LEU   A 1 65  ? -23.504 -64.673 -8.793  1.00 24.30  ? 328  LEU   A CD2 1 
ATOM   423  N  N   . THR   A 1 66  ? -18.560 -62.343 -8.116  1.00 20.68  ? 329  THR   A N   1 
ATOM   424  C  CA  . THR   A 1 66  ? -17.153 -62.172 -8.518  1.00 21.89  ? 329  THR   A CA  1 
ATOM   425  C  C   . THR   A 1 66  ? -16.241 -62.555 -7.340  1.00 20.39  ? 329  THR   A C   1 
ATOM   426  O  O   . THR   A 1 66  ? -15.210 -61.894 -7.100  1.00 21.16  ? 329  THR   A O   1 
ATOM   427  C  CB  . THR   A 1 66  ? -16.921 -60.757 -9.071  1.00 21.02  ? 329  THR   A CB  1 
ATOM   428  O  OG1 . THR   A 1 66  ? -17.332 -59.743 -8.143  1.00 19.71  ? 329  THR   A OG1 1 
ATOM   429  C  CG2 . THR   A 1 66  ? -17.645 -60.591 -10.391 1.00 22.48  ? 329  THR   A CG2 1 
ATOM   430  N  N   . LYS   A 1 67  ? -16.515 -63.681 -6.701  1.00 19.06  ? 330  LYS   A N   1 
ATOM   431  C  CA  . LYS   A 1 67  ? -15.777 -64.100 -5.490  1.00 21.61  ? 330  LYS   A CA  1 
ATOM   432  C  C   . LYS   A 1 67  ? -14.255 -64.116 -5.708  1.00 20.72  ? 330  LYS   A C   1 
ATOM   433  O  O   . LYS   A 1 67  ? -13.523 -63.717 -4.789  1.00 20.45  ? 330  LYS   A O   1 
ATOM   434  C  CB  . LYS   A 1 67  ? -16.315 -65.430 -4.968  1.00 25.39  ? 330  LYS   A CB  1 
ATOM   435  C  CG  . LYS   A 1 67  ? -15.801 -65.859 -3.608  1.00 25.82  ? 330  LYS   A CG  1 
ATOM   436  C  CD  . LYS   A 1 67  ? -16.384 -67.193 -3.178  1.00 28.26  ? 330  LYS   A CD  1 
ATOM   437  C  CE  . LYS   A 1 67  ? -16.134 -67.330 -1.677  1.00 33.44  ? 330  LYS   A CE  1 
ATOM   438  N  NZ  . LYS   A 1 67  ? -16.409 -68.697 -1.229  1.00 35.32  ? 330  LYS   A NZ  1 
ATOM   439  N  N   . PRO   A 1 68  ? -13.667 -64.641 -6.800  1.00 19.34  ? 331  PRO   A N   1 
ATOM   440  C  CA  . PRO   A 1 68  ? -12.206 -64.767 -6.905  1.00 20.72  ? 331  PRO   A CA  1 
ATOM   441  C  C   . PRO   A 1 68  ? -11.496 -63.412 -6.727  1.00 24.21  ? 331  PRO   A C   1 
ATOM   442  O  O   . PRO   A 1 68  ? -10.369 -63.361 -6.229  1.00 24.20  ? 331  PRO   A O   1 
ATOM   443  C  CB  . PRO   A 1 68  ? -11.962 -65.267 -8.341  1.00 22.74  ? 331  PRO   A CB  1 
ATOM   444  C  CG  . PRO   A 1 68  ? -13.206 -66.062 -8.652  1.00 24.12  ? 331  PRO   A CG  1 
ATOM   445  C  CD  . PRO   A 1 68  ? -14.337 -65.325 -7.929  1.00 23.07  ? 331  PRO   A CD  1 
ATOM   446  N  N   . TRP   A 1 69  ? -12.207 -62.315 -7.029  1.00 21.12  ? 332  TRP   A N   1 
ATOM   447  C  CA  . TRP   A 1 69  ? -11.649 -60.949 -6.960  1.00 21.67  ? 332  TRP   A CA  1 
ATOM   448  C  C   . TRP   A 1 69  ? -11.709 -60.422 -5.524  1.00 23.52  ? 332  TRP   A C   1 
ATOM   449  O  O   . TRP   A 1 69  ? -11.113 -59.376 -5.298  1.00 23.43  ? 332  TRP   A O   1 
ATOM   450  C  CB  . TRP   A 1 69  ? -12.284 -60.036 -8.022  1.00 22.02  ? 332  TRP   A CB  1 
ATOM   451  C  CG  . TRP   A 1 69  ? -11.928 -60.449 -9.414  1.00 20.60  ? 332  TRP   A CG  1 
ATOM   452  C  CD1 . TRP   A 1 69  ? -10.835 -60.005 -10.103 1.00 22.14  ? 332  TRP   A CD1 1 
ATOM   453  C  CD2 . TRP   A 1 69  ? -12.525 -61.483 -10.228 1.00 21.64  ? 332  TRP   A CD2 1 
ATOM   454  N  NE1 . TRP   A 1 69  ? -10.713 -60.666 -11.297 1.00 20.67  ? 332  TRP   A NE1 1 
ATOM   455  C  CE2 . TRP   A 1 69  ? -11.734 -61.574 -11.402 1.00 22.47  ? 332  TRP   A CE2 1 
ATOM   456  C  CE3 . TRP   A 1 69  ? -13.633 -62.327 -10.108 1.00 23.66  ? 332  TRP   A CE3 1 
ATOM   457  C  CZ2 . TRP   A 1 69  ? -12.069 -62.420 -12.447 1.00 23.73  ? 332  TRP   A CZ2 1 
ATOM   458  C  CZ3 . TRP   A 1 69  ? -13.963 -63.175 -11.150 1.00 22.37  ? 332  TRP   A CZ3 1 
ATOM   459  C  CH2 . TRP   A 1 69  ? -13.157 -63.255 -12.284 1.00 24.36  ? 332  TRP   A CH2 1 
ATOM   460  N  N   . ASP   A 1 70  ? -12.319 -61.144 -4.572  1.00 22.28  ? 333  ASP   A N   1 
ATOM   461  C  CA  . ASP   A 1 70  ? -12.352 -60.726 -3.148  1.00 20.55  ? 333  ASP   A CA  1 
ATOM   462  C  C   . ASP   A 1 70  ? -10.949 -60.663 -2.513  1.00 21.93  ? 333  ASP   A C   1 
ATOM   463  O  O   . ASP   A 1 70  ? -10.818 -60.011 -1.431  1.00 24.01  ? 333  ASP   A O   1 
ATOM   464  C  CB  . ASP   A 1 70  ? -13.253 -61.639 -2.311  1.00 21.55  ? 333  ASP   A CB  1 
ATOM   465  C  CG  . ASP   A 1 70  ? -14.743 -61.523 -2.621  1.00 22.50  ? 333  ASP   A CG  1 
ATOM   466  O  OD1 . ASP   A 1 70  ? -15.124 -60.574 -3.361  1.00 23.17  ? 333  ASP   A OD1 1 
ATOM   467  O  OD2 . ASP   A 1 70  ? -15.514 -62.341 -2.071  1.00 21.31  ? 333  ASP   A OD2 1 
ATOM   468  N  N   . ILE   A 1 71  ? -9.967  -61.325 -3.094  1.00 22.12  ? 334  ILE   A N   1 
ATOM   469  C  CA  . ILE   A 1 71  ? -8.580  -61.443 -2.579  1.00 25.22  ? 334  ILE   A CA  1 
ATOM   470  C  C   . ILE   A 1 71  ? -7.601  -60.737 -3.541  1.00 29.54  ? 334  ILE   A C   1 
ATOM   471  O  O   . ILE   A 1 71  ? -6.366  -60.965 -3.385  1.00 28.55  ? 334  ILE   A O   1 
ATOM   472  C  CB  . ILE   A 1 71  ? -8.186  -62.918 -2.313  1.00 26.00  ? 334  ILE   A CB  1 
ATOM   473  C  CG1 . ILE   A 1 71  ? -8.226  -63.766 -3.587  1.00 29.53  ? 334  ILE   A CG1 1 
ATOM   474  C  CG2 . ILE   A 1 71  ? -9.023  -63.551 -1.207  1.00 28.24  ? 334  ILE   A CG2 1 
ATOM   475  C  CD1 . ILE   A 1 71  ? -7.474  -65.091 -3.479  1.00 33.09  ? 334  ILE   A CD1 1 
ATOM   476  N  N   . ILE   A 1 72  ? -8.069  -59.870 -4.452  1.00 25.28  ? 335  ILE   A N   1 
ATOM   477  C  CA  . ILE   A 1 72  ? -7.206  -59.127 -5.419  1.00 24.11  ? 335  ILE   A CA  1 
ATOM   478  C  C   . ILE   A 1 72  ? -7.197  -57.682 -4.986  1.00 26.10  ? 335  ILE   A C   1 
ATOM   479  O  O   . ILE   A 1 72  ? -8.178  -56.958 -5.192  1.00 27.29  ? 335  ILE   A O   1 
ATOM   480  C  CB  . ILE   A 1 72  ? -7.731  -59.255 -6.865  1.00 29.93  ? 335  ILE   A CB  1 
ATOM   481  C  CG1 . ILE   A 1 72  ? -7.926  -60.709 -7.297  1.00 35.30  ? 335  ILE   A CG1 1 
ATOM   482  C  CG2 . ILE   A 1 72  ? -6.879  -58.441 -7.843  1.00 24.85  ? 335  ILE   A CG2 1 
ATOM   483  C  CD1 . ILE   A 1 72  ? -6.726  -61.411 -7.846  1.00 38.17  ? 335  ILE   A CD1 1 
ATOM   484  N  N   . PRO   A 1 73  ? -6.086  -57.198 -4.386  1.00 27.81  ? 336  PRO   A N   1 
ATOM   485  C  CA  . PRO   A 1 73  ? -6.044  -55.853 -3.832  1.00 30.17  ? 336  PRO   A CA  1 
ATOM   486  C  C   . PRO   A 1 73  ? -6.347  -54.768 -4.871  1.00 29.84  ? 336  PRO   A C   1 
ATOM   487  O  O   . PRO   A 1 73  ? -7.022  -53.802 -4.509  1.00 26.91  ? 336  PRO   A O   1 
ATOM   488  C  CB  . PRO   A 1 73  ? -4.621  -55.711 -3.239  1.00 34.85  ? 336  PRO   A CB  1 
ATOM   489  C  CG  . PRO   A 1 73  ? -4.154  -57.136 -3.045  1.00 38.09  ? 336  PRO   A CG  1 
ATOM   490  C  CD  . PRO   A 1 73  ? -4.866  -57.970 -4.098  1.00 31.23  ? 336  PRO   A CD  1 
ATOM   491  N  N   . MET   A 1 74  ? -5.956  -54.941 -6.131  1.00 27.63  ? 337  MET   A N   1 
ATOM   492  C  CA  . MET   A 1 74  ? -6.267  -53.878 -7.124  1.00 32.56  ? 337  MET   A CA  1 
ATOM   493  C  C   . MET   A 1 74  ? -7.792  -53.696 -7.267  1.00 34.78  ? 337  MET   A C   1 
ATOM   494  O  O   . MET   A 1 74  ? -8.221  -52.569 -7.540  1.00 32.87  ? 337  MET   A O   1 
ATOM   495  C  CB  . MET   A 1 74  ? -5.643  -54.172 -8.487  1.00 34.99  ? 337  MET   A CB  1 
ATOM   496  C  CG  . MET   A 1 74  ? -4.106  -54.124 -8.467  1.00 45.56  ? 337  MET   A CG  1 
ATOM   497  S  SD  . MET   A 1 74  ? -3.470  -52.388 -8.210  1.00 52.16  ? 337  MET   A SD  1 
ATOM   498  C  CE  . MET   A 1 74  ? -4.638  -51.448 -9.194  1.00 47.91  ? 337  MET   A CE  1 
ATOM   499  N  N   . VAL   A 1 75  ? -8.594  -54.734 -7.022  1.00 26.07  ? 338  VAL   A N   1 
ATOM   500  C  CA  . VAL   A 1 75  ? -10.084 -54.636 -7.041  1.00 24.52  ? 338  VAL   A CA  1 
ATOM   501  C  C   . VAL   A 1 75  ? -10.566 -54.106 -5.695  1.00 25.63  ? 338  VAL   A C   1 
ATOM   502  O  O   . VAL   A 1 75  ? -11.327 -53.168 -5.679  1.00 28.95  ? 338  VAL   A O   1 
ATOM   503  C  CB  . VAL   A 1 75  ? -10.762 -56.010 -7.321  1.00 22.29  ? 338  VAL   A CB  1 
ATOM   504  C  CG1 . VAL   A 1 75  ? -12.262 -55.983 -7.026  1.00 23.76  ? 338  VAL   A CG1 1 
ATOM   505  C  CG2 . VAL   A 1 75  ? -10.480 -56.443 -8.752  1.00 22.48  ? 338  VAL   A CG2 1 
ATOM   506  N  N   . THR   A 1 76  ? -10.159 -54.738 -4.610  1.00 23.60  ? 339  THR   A N   1 
ATOM   507  C  CA  . THR   A 1 76  ? -10.743 -54.495 -3.274  1.00 24.88  ? 339  THR   A CA  1 
ATOM   508  C  C   . THR   A 1 76  ? -10.397 -53.104 -2.772  1.00 27.25  ? 339  THR   A C   1 
ATOM   509  O  O   . THR   A 1 76  ? -11.285 -52.492 -2.154  1.00 27.02  ? 339  THR   A O   1 
ATOM   510  C  CB  . THR   A 1 76  ? -10.331 -55.569 -2.256  1.00 28.25  ? 339  THR   A CB  1 
ATOM   511  O  OG1 . THR   A 1 76  ? -8.910  -55.548 -2.073  1.00 27.86  ? 339  THR   A OG1 1 
ATOM   512  C  CG2 . THR   A 1 76  ? -10.809 -56.941 -2.684  1.00 29.87  ? 339  THR   A CG2 1 
ATOM   513  N  N   . GLN   A 1 77  ? -9.208  -52.584 -3.110  1.00 27.12  ? 340  GLN   A N   1 
ATOM   514  C  CA  . GLN   A 1 77  ? -8.771  -51.244 -2.643  1.00 30.49  ? 340  GLN   A CA  1 
ATOM   515  C  C   . GLN   A 1 77  ? -9.579  -50.149 -3.347  1.00 30.38  ? 340  GLN   A C   1 
ATOM   516  O  O   . GLN   A 1 77  ? -9.686  -49.073 -2.746  1.00 30.54  ? 340  GLN   A O   1 
ATOM   517  C  CB  . GLN   A 1 77  ? -7.262  -51.050 -2.798  1.00 32.62  ? 340  GLN   A CB  1 
ATOM   518  C  CG  . GLN   A 1 77  ? -6.465  -52.216 -2.258  1.00 45.55  ? 340  GLN   A CG  1 
ATOM   519  C  CD  . GLN   A 1 77  ? -5.823  -52.013 -0.912  1.00 61.75  ? 340  GLN   A CD  1 
ATOM   520  O  OE1 . GLN   A 1 77  ? -6.334  -51.273 -0.074  1.00 63.14  ? 340  GLN   A OE1 1 
ATOM   521  N  NE2 . GLN   A 1 77  ? -4.702  -52.701 -0.705  1.00 65.92  ? 340  GLN   A NE2 1 
ATOM   522  N  N   . MET   A 1 78  ? -10.157 -50.401 -4.531  1.00 27.01  ? 341  MET   A N   1 
ATOM   523  C  CA  . MET   A 1 78  ? -10.925 -49.360 -5.271  1.00 30.55  ? 341  MET   A CA  1 
ATOM   524  C  C   . MET   A 1 78  ? -12.161 -48.922 -4.496  1.00 27.35  ? 341  MET   A C   1 
ATOM   525  O  O   . MET   A 1 78  ? -12.573 -47.783 -4.683  1.00 28.25  ? 341  MET   A O   1 
ATOM   526  C  CB  . MET   A 1 78  ? -11.374 -49.823 -6.664  1.00 30.64  ? 341  MET   A CB  1 
ATOM   527  C  CG  . MET   A 1 78  ? -10.237 -50.103 -7.587  1.00 39.03  ? 341  MET   A CG  1 
ATOM   528  S  SD  . MET   A 1 78  ? -10.816 -50.476 -9.325  1.00 42.31  ? 341  MET   A SD  1 
ATOM   529  C  CE  . MET   A 1 78  ? -12.136 -49.287 -9.361  1.00 28.63  ? 341  MET   A CE  1 
ATOM   530  N  N   . ALA   A 1 79  ? -12.739 -49.782 -3.646  1.00 27.60  ? 342  ALA   A N   1 
ATOM   531  C  CA  . ALA   A 1 79  ? -13.968 -49.491 -2.869  1.00 33.30  ? 342  ALA   A CA  1 
ATOM   532  C  C   . ALA   A 1 79  ? -13.627 -48.729 -1.574  1.00 32.40  ? 342  ALA   A C   1 
ATOM   533  O  O   . ALA   A 1 79  ? -14.566 -48.189 -0.960  1.00 31.70  ? 342  ALA   A O   1 
ATOM   534  C  CB  . ALA   A 1 79  ? -14.706 -50.798 -2.585  1.00 34.81  ? 342  ALA   A CB  1 
ATOM   535  N  N   . MET   A 1 80  ? -12.360 -48.639 -1.156  1.00 34.55  ? 343  MET   A N   1 
ATOM   536  C  CA  . MET   A 1 80  ? -12.010 -47.990 0.146   1.00 37.96  ? 343  MET   A CA  1 
ATOM   537  C  C   . MET   A 1 80  ? -11.871 -46.456 -0.007  1.00 50.59  ? 343  MET   A C   1 
ATOM   538  O  O   . MET   A 1 80  ? -11.389 -46.003 -1.071  1.00 50.87  ? 343  MET   A O   1 
ATOM   539  C  CB  . MET   A 1 80  ? -10.697 -48.562 0.698   1.00 37.45  ? 343  MET   A CB  1 
ATOM   540  C  CG  . MET   A 1 80  ? -10.718 -50.075 0.799   1.00 38.57  ? 343  MET   A CG  1 
ATOM   541  S  SD  . MET   A 1 80  ? -12.125 -50.679 1.832   1.00 44.66  ? 343  MET   A SD  1 
ATOM   542  C  CE  . MET   A 1 80  ? -11.546 -50.238 3.469   1.00 45.72  ? 343  MET   A CE  1 
ATOM   543  N  N   . THR   A 1 81  ? -12.249 -45.682 1.026   1.00 63.74  ? 344  THR   A N   1 
ATOM   544  C  CA  . THR   A 1 81  ? -11.753 -44.300 1.266   1.00 68.87  ? 344  THR   A CA  1 
ATOM   545  C  C   . THR   A 1 81  ? -12.866 -43.277 1.430   1.00 63.25  ? 344  THR   A C   1 
ATOM   546  O  O   . THR   A 1 81  ? -14.048 -43.692 1.381   1.00 73.30  ? 344  THR   A O   1 
ATOM   547  N  N   . LYS   A 1 93  ? -7.236  -26.882 -3.674  0.50 91.08  ? 356  LYS   A N   1 
ATOM   548  C  CA  . LYS   A 1 93  ? -6.255  -27.980 -3.900  0.50 94.77  ? 356  LYS   A CA  1 
ATOM   549  C  C   . LYS   A 1 93  ? -4.893  -27.366 -4.260  0.50 96.75  ? 356  LYS   A C   1 
ATOM   550  O  O   . LYS   A 1 93  ? -4.785  -26.121 -4.240  0.50 96.84  ? 356  LYS   A O   1 
ATOM   551  C  CB  . LYS   A 1 93  ? -6.766  -28.926 -4.993  0.50 93.18  ? 356  LYS   A CB  1 
ATOM   552  C  CG  . LYS   A 1 93  ? -6.101  -30.297 -5.043  0.50 90.92  ? 356  LYS   A CG  1 
ATOM   553  C  CD  . LYS   A 1 93  ? -6.321  -31.038 -6.352  0.50 89.55  ? 356  LYS   A CD  1 
ATOM   554  C  CE  . LYS   A 1 93  ? -7.782  -31.271 -6.679  0.50 87.69  ? 356  LYS   A CE  1 
ATOM   555  N  NZ  . LYS   A 1 93  ? -7.972  -31.696 -8.087  0.50 86.05  ? 356  LYS   A NZ  1 
ATOM   556  N  N   . GLU   A 1 94  ? -3.898  -28.208 -4.571  0.50 96.59  ? 357  GLU   A N   1 
ATOM   557  C  CA  . GLU   A 1 94  ? -2.502  -27.796 -4.890  0.50 95.00  ? 357  GLU   A CA  1 
ATOM   558  C  C   . GLU   A 1 94  ? -2.266  -27.867 -6.404  0.50 91.52  ? 357  GLU   A C   1 
ATOM   559  O  O   . GLU   A 1 94  ? -1.098  -28.028 -6.808  0.50 87.71  ? 357  GLU   A O   1 
ATOM   560  C  CB  . GLU   A 1 94  ? -1.496  -28.685 -4.155  0.50 98.86  ? 357  GLU   A CB  1 
ATOM   561  C  CG  . GLU   A 1 94  ? -1.650  -28.647 -2.646  0.50 100.70 ? 357  GLU   A CG  1 
ATOM   562  C  CD  . GLU   A 1 94  ? -3.047  -28.986 -2.156  0.50 102.54 ? 357  GLU   A CD  1 
ATOM   563  O  OE1 . GLU   A 1 94  ? -3.469  -28.415 -1.128  0.50 105.16 ? 357  GLU   A OE1 1 
ATOM   564  O  OE2 . GLU   A 1 94  ? -3.712  -29.820 -2.804  0.50 102.28 ? 357  GLU   A OE2 1 
ATOM   565  N  N   . LYS   A 1 95  ? -3.338  -27.760 -7.199  0.50 89.94  ? 358  LYS   A N   1 
ATOM   566  C  CA  . LYS   A 1 95  ? -3.289  -27.650 -8.684  0.50 84.47  ? 358  LYS   A CA  1 
ATOM   567  C  C   . LYS   A 1 95  ? -4.287  -26.579 -9.139  0.50 78.28  ? 358  LYS   A C   1 
ATOM   568  O  O   . LYS   A 1 95  ? -4.013  -25.911 -10.154 0.50 76.45  ? 358  LYS   A O   1 
ATOM   569  C  CB  . LYS   A 1 95  ? -3.596  -28.998 -9.342  0.50 85.19  ? 358  LYS   A CB  1 
ATOM   570  C  CG  . LYS   A 1 95  ? -3.096  -29.139 -10.774 0.50 84.83  ? 358  LYS   A CG  1 
ATOM   571  C  CD  . LYS   A 1 95  ? -2.972  -30.577 -11.220 0.50 85.07  ? 358  LYS   A CD  1 
ATOM   572  C  CE  . LYS   A 1 95  ? -1.865  -30.786 -12.231 0.50 86.24  ? 358  LYS   A CE  1 
ATOM   573  N  NZ  . LYS   A 1 95  ? -1.693  -32.221 -12.558 0.50 85.55  ? 358  LYS   A NZ  1 
ATOM   574  N  N   . VAL   A 1 96  ? -5.397  -26.430 -8.409  0.50 75.31  ? 359  VAL   A N   1 
ATOM   575  C  CA  . VAL   A 1 96  ? -6.433  -25.381 -8.644  0.50 72.78  ? 359  VAL   A CA  1 
ATOM   576  C  C   . VAL   A 1 96  ? -5.859  -24.028 -8.207  0.50 70.33  ? 359  VAL   A C   1 
ATOM   577  O  O   . VAL   A 1 96  ? -6.128  -23.026 -8.895  0.50 66.21  ? 359  VAL   A O   1 
ATOM   578  C  CB  . VAL   A 1 96  ? -7.746  -25.694 -7.899  0.50 73.93  ? 359  VAL   A CB  1 
ATOM   579  C  CG1 . VAL   A 1 96  ? -7.600  -25.519 -6.393  0.50 74.16  ? 359  VAL   A CG1 1 
ATOM   580  C  CG2 . VAL   A 1 96  ? -8.902  -24.856 -8.424  0.50 72.35  ? 359  VAL   A CG2 1 
ATOM   581  N  N   . ASP   A 1 97  ? -5.100  -24.008 -7.106  0.50 68.97  ? 360  ASP   A N   1 
ATOM   582  C  CA  . ASP   A 1 97  ? -4.528  -22.774 -6.502  0.50 67.50  ? 360  ASP   A CA  1 
ATOM   583  C  C   . ASP   A 1 97  ? -3.157  -22.486 -7.133  0.50 70.54  ? 360  ASP   A C   1 
ATOM   584  O  O   . ASP   A 1 97  ? -2.275  -21.968 -6.417  0.50 72.57  ? 360  ASP   A O   1 
ATOM   585  C  CB  . ASP   A 1 97  ? -4.454  -22.898 -4.976  0.50 64.86  ? 360  ASP   A CB  1 
ATOM   586  C  CG  . ASP   A 1 97  ? -4.398  -21.567 -4.242  0.50 63.19  ? 360  ASP   A CG  1 
ATOM   587  O  OD1 . ASP   A 1 97  ? -4.201  -20.531 -4.907  0.50 60.94  ? 360  ASP   A OD1 1 
ATOM   588  O  OD2 . ASP   A 1 97  ? -4.549  -21.577 -3.005  0.50 65.82  ? 360  ASP   A OD2 1 
ATOM   589  N  N   . THR   A 1 98  ? -2.992  -22.799 -8.424  0.50 72.19  ? 361  THR   A N   1 
ATOM   590  C  CA  . THR   A 1 98  ? -1.787  -22.470 -9.236  0.50 75.08  ? 361  THR   A CA  1 
ATOM   591  C  C   . THR   A 1 98  ? -2.151  -21.384 -10.256 0.50 76.99  ? 361  THR   A C   1 
ATOM   592  O  O   . THR   A 1 98  ? -3.354  -21.080 -10.391 0.50 74.85  ? 361  THR   A O   1 
ATOM   593  C  CB  . THR   A 1 98  ? -1.203  -23.713 -9.923  0.50 75.94  ? 361  THR   A CB  1 
ATOM   594  O  OG1 . THR   A 1 98  ? -2.102  -24.138 -10.949 0.50 73.04  ? 361  THR   A OG1 1 
ATOM   595  C  CG2 . THR   A 1 98  ? -0.947  -24.853 -8.961  0.50 75.81  ? 361  THR   A CG2 1 
ATOM   596  N  N   . ARG   A 1 99  ? -1.148  -20.822 -10.938 0.50 80.74  ? 362  ARG   A N   1 
ATOM   597  C  CA  . ARG   A 1 99  ? -1.322  -19.722 -11.924 0.50 89.33  ? 362  ARG   A CA  1 
ATOM   598  C  C   . ARG   A 1 99  ? -0.684  -20.134 -13.256 0.50 92.63  ? 362  ARG   A C   1 
ATOM   599  O  O   . ARG   A 1 99  ? 0.265   -20.947 -13.229 0.50 92.03  ? 362  ARG   A O   1 
ATOM   600  C  CB  . ARG   A 1 99  ? -0.700  -18.427 -11.391 0.50 94.34  ? 362  ARG   A CB  1 
ATOM   601  C  CG  . ARG   A 1 99  ? -1.412  -17.159 -11.841 0.50 99.30  ? 362  ARG   A CG  1 
ATOM   602  C  CD  . ARG   A 1 99  ? -0.502  -15.944 -11.797 0.50 103.44 ? 362  ARG   A CD  1 
ATOM   603  N  NE  . ARG   A 1 99  ? 0.527   -15.999 -12.828 0.50 106.64 ? 362  ARG   A NE  1 
ATOM   604  C  CZ  . ARG   A 1 99  ? 1.552   -15.160 -12.919 0.50 105.06 ? 362  ARG   A CZ  1 
ATOM   605  N  NH1 . ARG   A 1 99  ? 1.693   -14.189 -12.032 0.50 106.05 ? 362  ARG   A NH1 1 
ATOM   606  N  NH2 . ARG   A 1 99  ? 2.433   -15.295 -13.895 0.50 103.47 ? 362  ARG   A NH2 1 
ATOM   607  N  N   . THR   A 1 100 ? -1.194  -19.592 -14.368 1.00 95.14  ? 363  THR   A N   1 
ATOM   608  C  CA  . THR   A 1 100 ? -0.698  -19.867 -15.746 1.00 87.30  ? 363  THR   A CA  1 
ATOM   609  C  C   . THR   A 1 100 ? -0.231  -18.547 -16.370 1.00 77.50  ? 363  THR   A C   1 
ATOM   610  O  O   . THR   A 1 100 ? -1.052  -17.622 -16.451 1.00 94.51  ? 363  THR   A O   1 
ATOM   611  C  CB  . THR   A 1 100 ? -1.802  -20.527 -16.582 1.00 90.55  ? 363  THR   A CB  1 
ATOM   612  O  OG1 . THR   A 1 100 ? -2.396  -21.569 -15.806 1.00 84.21  ? 363  THR   A OG1 1 
ATOM   613  C  CG2 . THR   A 1 100 ? -1.304  -21.083 -17.900 1.00 91.36  ? 363  THR   A CG2 1 
ATOM   614  N  N   . GLN   A 1 101 ? 1.029   -18.455 -16.796 1.00 75.52  ? 364  GLN   A N   1 
ATOM   615  C  CA  . GLN   A 1 101 ? 1.600   -17.206 -17.372 1.00 82.27  ? 364  GLN   A CA  1 
ATOM   616  C  C   . GLN   A 1 101 ? 0.868   -16.844 -18.677 1.00 75.56  ? 364  GLN   A C   1 
ATOM   617  O  O   . GLN   A 1 101 ? 0.371   -17.742 -19.357 1.00 70.45  ? 364  GLN   A O   1 
ATOM   618  C  CB  . GLN   A 1 101 ? 3.111   -17.342 -17.595 1.00 83.96  ? 364  GLN   A CB  1 
ATOM   619  C  CG  . GLN   A 1 101 ? 3.715   -16.133 -18.302 1.00 92.65  ? 364  GLN   A CG  1 
ATOM   620  C  CD  . GLN   A 1 101 ? 5.215   -16.042 -18.171 1.00 100.55 ? 364  GLN   A CD  1 
ATOM   621  O  OE1 . GLN   A 1 101 ? 5.914   -17.052 -18.191 1.00 106.80 ? 364  GLN   A OE1 1 
ATOM   622  N  NE2 . GLN   A 1 101 ? 5.722   -14.823 -18.043 1.00 96.50  ? 364  GLN   A NE2 1 
ATOM   623  N  N   . GLU   A 1 102 ? 0.814   -15.554 -19.008 1.00 76.29  ? 365  GLU   A N   1 
ATOM   624  C  CA  . GLU   A 1 102 ? 0.273   -15.024 -20.284 1.00 70.03  ? 365  GLU   A CA  1 
ATOM   625  C  C   . GLU   A 1 102 ? 1.106   -15.570 -21.443 1.00 64.31  ? 365  GLU   A C   1 
ATOM   626  O  O   . GLU   A 1 102 ? 2.338   -15.488 -21.437 1.00 59.02  ? 365  GLU   A O   1 
ATOM   627  C  CB  . GLU   A 1 102 ? 0.286   -13.489 -20.249 1.00 84.40  ? 365  GLU   A CB  1 
ATOM   628  C  CG  . GLU   A 1 102 ? -0.202  -12.803 -21.525 1.00 93.54  ? 365  GLU   A CG  1 
ATOM   629  C  CD  . GLU   A 1 102 ? -1.645  -12.309 -21.542 1.00 99.91  ? 365  GLU   A CD  1 
ATOM   630  O  OE1 . GLU   A 1 102 ? -1.881  -11.205 -22.090 1.00 103.44 ? 365  GLU   A OE1 1 
ATOM   631  O  OE2 . GLU   A 1 102 ? -2.534  -13.036 -21.048 1.00 95.48  ? 365  GLU   A OE2 1 
ATOM   632  N  N   . PRO   A 1 103 ? 0.471   -16.142 -22.493 1.00 50.03  ? 366  PRO   A N   1 
ATOM   633  C  CA  . PRO   A 1 103 ? 1.210   -16.549 -23.681 1.00 47.46  ? 366  PRO   A CA  1 
ATOM   634  C  C   . PRO   A 1 103 ? 1.826   -15.320 -24.359 1.00 50.09  ? 366  PRO   A C   1 
ATOM   635  O  O   . PRO   A 1 103 ? 1.287   -14.247 -24.209 1.00 45.60  ? 366  PRO   A O   1 
ATOM   636  C  CB  . PRO   A 1 103 ? 0.151   -17.217 -24.568 1.00 49.54  ? 366  PRO   A CB  1 
ATOM   637  C  CG  . PRO   A 1 103 ? -0.937  -17.620 -23.589 1.00 50.76  ? 366  PRO   A CG  1 
ATOM   638  C  CD  . PRO   A 1 103 ? -0.953  -16.497 -22.574 1.00 50.54  ? 366  PRO   A CD  1 
ATOM   639  N  N   . LYS   A 1 104 ? 2.881   -15.545 -25.134 1.00 48.30  ? 367  LYS   A N   1 
ATOM   640  C  CA  . LYS   A 1 104 ? 3.605   -14.519 -25.931 1.00 53.59  ? 367  LYS   A CA  1 
ATOM   641  C  C   . LYS   A 1 104 ? 2.702   -14.068 -27.085 1.00 53.52  ? 367  LYS   A C   1 
ATOM   642  O  O   . LYS   A 1 104 ? 1.712   -14.754 -27.371 1.00 45.49  ? 367  LYS   A O   1 
ATOM   643  C  CB  . LYS   A 1 104 ? 4.929   -15.093 -26.462 1.00 59.09  ? 367  LYS   A CB  1 
ATOM   644  C  CG  . LYS   A 1 104 ? 5.889   -15.690 -25.424 1.00 63.78  ? 367  LYS   A CG  1 
ATOM   645  C  CD  . LYS   A 1 104 ? 6.774   -14.669 -24.732 1.00 71.04  ? 367  LYS   A CD  1 
ATOM   646  C  CE  . LYS   A 1 104 ? 7.677   -15.266 -23.672 1.00 70.58  ? 367  LYS   A CE  1 
ATOM   647  N  NZ  . LYS   A 1 104 ? 7.052   -15.190 -22.329 1.00 66.28  ? 367  LYS   A NZ  1 
ATOM   648  N  N   . GLU   A 1 105 ? 3.073   -12.981 -27.755 1.00 48.22  ? 368  GLU   A N   1 
ATOM   649  C  CA  . GLU   A 1 105 ? 2.269   -12.302 -28.798 1.00 53.67  ? 368  GLU   A CA  1 
ATOM   650  C  C   . GLU   A 1 105 ? 2.053   -13.221 -30.000 1.00 49.80  ? 368  GLU   A C   1 
ATOM   651  O  O   . GLU   A 1 105 ? 0.909   -13.258 -30.493 1.00 48.02  ? 368  GLU   A O   1 
ATOM   652  C  CB  . GLU   A 1 105 ? 2.964   -11.003 -29.233 1.00 64.77  ? 368  GLU   A CB  1 
ATOM   653  C  CG  . GLU   A 1 105 ? 2.993   -9.951  -28.129 1.00 73.39  ? 368  GLU   A CG  1 
ATOM   654  C  CD  . GLU   A 1 105 ? 1.619   -9.465  -27.701 1.00 76.80  ? 368  GLU   A CD  1 
ATOM   655  O  OE1 . GLU   A 1 105 ? 0.895   -8.944  -28.576 1.00 86.10  ? 368  GLU   A OE1 1 
ATOM   656  O  OE2 . GLU   A 1 105 ? 1.269   -9.628  -26.508 1.00 62.73  ? 368  GLU   A OE2 1 
ATOM   657  N  N   . GLY   A 1 106 ? 3.125   -13.847 -30.496 1.00 42.22  ? 369  GLY   A N   1 
ATOM   658  C  CA  . GLY   A 1 106 ? 3.088   -14.857 -31.562 1.00 43.36  ? 369  GLY   A CA  1 
ATOM   659  C  C   . GLY   A 1 106 ? 2.086   -15.966 -31.226 1.00 40.02  ? 369  GLY   A C   1 
ATOM   660  O  O   . GLY   A 1 106 ? 1.255   -16.277 -32.107 1.00 40.76  ? 369  GLY   A O   1 
ATOM   661  N  N   . THR   A 1 107 ? 2.143   -16.517 -30.015 1.00 38.01  ? 370  THR   A N   1 
ATOM   662  C  CA  . THR   A 1 107 ? 1.224   -17.604 -29.566 1.00 41.09  ? 370  THR   A CA  1 
ATOM   663  C  C   . THR   A 1 107 ? -0.230  -17.114 -29.619 1.00 45.33  ? 370  THR   A C   1 
ATOM   664  O  O   . THR   A 1 107 ? -1.088  -17.806 -30.215 1.00 38.72  ? 370  THR   A O   1 
ATOM   665  C  CB  . THR   A 1 107 ? 1.594   -18.124 -28.188 1.00 42.37  ? 370  THR   A CB  1 
ATOM   666  O  OG1 . THR   A 1 107 ? 2.992   -18.416 -28.268 1.00 45.31  ? 370  THR   A OG1 1 
ATOM   667  C  CG2 . THR   A 1 107 ? 0.808   -19.367 -27.810 1.00 43.18  ? 370  THR   A CG2 1 
ATOM   668  N  N   . LYS   A 1 108 ? -0.492  -15.960 -28.995 0.50 44.87  ? 371  LYS   A N   1 
ATOM   669  C  CA  . LYS   A 1 108 ? -1.838  -15.330 -28.890 0.50 45.67  ? 371  LYS   A CA  1 
ATOM   670  C  C   . LYS   A 1 108 ? -2.441  -15.116 -30.285 0.50 44.11  ? 371  LYS   A C   1 
ATOM   671  O  O   . LYS   A 1 108 ? -3.662  -15.299 -30.424 0.50 43.45  ? 371  LYS   A O   1 
ATOM   672  C  CB  . LYS   A 1 108 ? -1.739  -14.019 -28.105 0.50 49.28  ? 371  LYS   A CB  1 
ATOM   673  C  CG  . LYS   A 1 108 ? -1.599  -14.197 -26.600 0.50 52.03  ? 371  LYS   A CG  1 
ATOM   674  C  CD  . LYS   A 1 108 ? -1.715  -12.909 -25.813 0.50 53.88  ? 371  LYS   A CD  1 
ATOM   675  C  CE  . LYS   A 1 108 ? -0.538  -11.984 -26.039 0.50 58.21  ? 371  LYS   A CE  1 
ATOM   676  N  NZ  . LYS   A 1 108 ? -0.380  -11.014 -24.929 0.50 59.81  ? 371  LYS   A NZ  1 
ATOM   677  N  N   . LYS   A 1 109 ? -1.623  -14.759 -31.280 0.50 43.60  ? 372  LYS   A N   1 
ATOM   678  C  CA  . LYS   A 1 109 ? -2.067  -14.550 -32.684 0.50 46.44  ? 372  LYS   A CA  1 
ATOM   679  C  C   . LYS   A 1 109 ? -2.373  -15.903 -33.343 0.50 45.39  ? 372  LYS   A C   1 
ATOM   680  O  O   . LYS   A 1 109 ? -3.403  -15.991 -34.048 0.50 45.38  ? 372  LYS   A O   1 
ATOM   681  C  CB  . LYS   A 1 109 ? -1.004  -13.792 -33.485 0.50 50.13  ? 372  LYS   A CB  1 
ATOM   682  C  CG  . LYS   A 1 109 ? -1.374  -13.522 -34.939 0.50 55.82  ? 372  LYS   A CG  1 
ATOM   683  C  CD  . LYS   A 1 109 ? -2.593  -12.629 -35.103 0.50 58.66  ? 372  LYS   A CD  1 
ATOM   684  C  CE  . LYS   A 1 109 ? -2.314  -11.188 -34.732 0.50 60.82  ? 372  LYS   A CE  1 
ATOM   685  N  NZ  . LYS   A 1 109 ? -3.527  -10.347 -34.850 0.50 62.63  ? 372  LYS   A NZ  1 
ATOM   686  N  N   . LEU   A 1 110 ? -1.501  -16.903 -33.149 1.00 42.23  ? 373  LEU   A N   1 
ATOM   687  C  CA  . LEU   A 1 110 ? -1.715  -18.288 -33.692 1.00 42.22  ? 373  LEU   A CA  1 
ATOM   688  C  C   . LEU   A 1 110 ? -3.053  -18.822 -33.168 1.00 32.00  ? 373  LEU   A C   1 
ATOM   689  O  O   . LEU   A 1 110 ? -3.854  -19.293 -33.992 1.00 33.55  ? 373  LEU   A O   1 
ATOM   690  C  CB  . LEU   A 1 110 ? -0.583  -19.238 -33.296 1.00 38.34  ? 373  LEU   A CB  1 
ATOM   691  C  CG  . LEU   A 1 110 ? 0.754   -18.983 -33.997 1.00 35.87  ? 373  LEU   A CG  1 
ATOM   692  C  CD1 . LEU   A 1 110 ? 1.896   -19.668 -33.236 1.00 35.59  ? 373  LEU   A CD1 1 
ATOM   693  C  CD2 . LEU   A 1 110 ? 0.681   -19.434 -35.455 1.00 38.08  ? 373  LEU   A CD2 1 
ATOM   694  N  N   . MET   A 1 111 ? -3.287  -18.681 -31.879 1.00 29.34  ? 374  MET   A N   1 
ATOM   695  C  CA  . MET   A 1 111 ? -4.544  -19.183 -31.278 1.00 32.56  ? 374  MET   A CA  1 
ATOM   696  C  C   . MET   A 1 111 ? -5.771  -18.443 -31.855 1.00 36.62  ? 374  MET   A C   1 
ATOM   697  O  O   . MET   A 1 111 ? -6.798  -19.094 -32.108 1.00 30.78  ? 374  MET   A O   1 
ATOM   698  C  CB  . MET   A 1 111 ? -4.515  -19.081 -29.749 1.00 33.05  ? 374  MET   A CB  1 
ATOM   699  C  CG  . MET   A 1 111 ? -3.482  -20.014 -29.117 1.00 33.86  ? 374  MET   A CG  1 
ATOM   700  S  SD  . MET   A 1 111 ? -3.617  -20.168 -27.350 1.00 39.98  ? 374  MET   A SD  1 
ATOM   701  C  CE  . MET   A 1 111 ? -3.180  -18.509 -26.841 1.00 37.23  ? 374  MET   A CE  1 
ATOM   702  N  N   . LYS   A 1 112 ? -5.666  -17.124 -32.063 0.50 35.53  ? 375  LYS   A N   1 
ATOM   703  C  CA  . LYS   A 1 112 ? -6.819  -16.277 -32.461 0.50 36.86  ? 375  LYS   A CA  1 
ATOM   704  C  C   . LYS   A 1 112 ? -7.197  -16.615 -33.908 0.50 35.42  ? 375  LYS   A C   1 
ATOM   705  O  O   . LYS   A 1 112 ? -8.404  -16.818 -34.164 0.50 36.78  ? 375  LYS   A O   1 
ATOM   706  C  CB  . LYS   A 1 112 ? -6.499  -14.789 -32.263 0.50 41.96  ? 375  LYS   A CB  1 
ATOM   707  C  CG  . LYS   A 1 112 ? -7.453  -14.041 -31.338 0.50 44.52  ? 375  LYS   A CG  1 
ATOM   708  C  CD  . LYS   A 1 112 ? -7.146  -14.228 -29.852 0.50 46.11  ? 375  LYS   A CD  1 
ATOM   709  C  CE  . LYS   A 1 112 ? -8.231  -13.700 -28.933 0.50 45.83  ? 375  LYS   A CE  1 
ATOM   710  N  NZ  . LYS   A 1 112 ? -7.844  -13.771 -27.502 0.50 46.12  ? 375  LYS   A NZ  1 
ATOM   711  N  N   . ILE   A 1 113 ? -6.200  -16.703 -34.800 1.00 33.27  ? 376  ILE   A N   1 
ATOM   712  C  CA  . ILE   A 1 113 ? -6.401  -17.121 -36.214 1.00 32.75  ? 376  ILE   A CA  1 
ATOM   713  C  C   . ILE   A 1 113 ? -6.998  -18.539 -36.284 1.00 38.76  ? 376  ILE   A C   1 
ATOM   714  O  O   . ILE   A 1 113 ? -7.930  -18.779 -37.122 1.00 33.03  ? 376  ILE   A O   1 
ATOM   715  C  CB  . ILE   A 1 113 ? -5.079  -17.054 -37.003 1.00 33.64  ? 376  ILE   A CB  1 
ATOM   716  C  CG1 . ILE   A 1 113 ? -4.562  -15.619 -37.136 1.00 41.28  ? 376  ILE   A CG1 1 
ATOM   717  C  CG2 . ILE   A 1 113 ? -5.220  -17.677 -38.371 1.00 35.07  ? 376  ILE   A CG2 1 
ATOM   718  C  CD1 . ILE   A 1 113 ? -3.145  -15.587 -37.659 1.00 39.07  ? 376  ILE   A CD1 1 
ATOM   719  N  N   . THR   A 1 114 ? -6.432  -19.485 -35.526 1.00 34.51  ? 377  THR   A N   1 
ATOM   720  C  CA  . THR   A 1 114 ? -6.892  -20.898 -35.575 1.00 31.35  ? 377  THR   A CA  1 
ATOM   721  C  C   . THR   A 1 114 ? -8.316  -20.994 -35.025 1.00 28.56  ? 377  THR   A C   1 
ATOM   722  O  O   . THR   A 1 114 ? -9.169  -21.641 -35.658 1.00 28.58  ? 377  THR   A O   1 
ATOM   723  C  CB  . THR   A 1 114 ? -5.909  -21.792 -34.809 1.00 32.59  ? 377  THR   A CB  1 
ATOM   724  O  OG1 . THR   A 1 114 ? -4.637  -21.527 -35.402 1.00 29.26  ? 377  THR   A OG1 1 
ATOM   725  C  CG2 . THR   A 1 114 ? -6.220  -23.263 -34.970 1.00 31.83  ? 377  THR   A CG2 1 
ATOM   726  N  N   . ALA   A 1 115 ? -8.590  -20.340 -33.907 1.00 29.41  ? 378  ALA   A N   1 
ATOM   727  C  CA  . ALA   A 1 115 ? -9.928  -20.368 -33.294 1.00 32.79  ? 378  ALA   A CA  1 
ATOM   728  C  C   . ALA   A 1 115 ? -10.987 -19.786 -34.244 1.00 35.33  ? 378  ALA   A C   1 
ATOM   729  O  O   . ALA   A 1 115 ? -12.084 -20.396 -34.409 1.00 31.65  ? 378  ALA   A O   1 
ATOM   730  C  CB  . ALA   A 1 115 ? -9.890  -19.695 -31.966 1.00 32.51  ? 378  ALA   A CB  1 
ATOM   731  N  N   . GLU   A 1 116 ? -10.684 -18.647 -34.871 0.50 34.60  ? 379  GLU   A N   1 
ATOM   732  C  CA  . GLU   A 1 116 ? -11.594 -17.982 -35.846 0.50 35.74  ? 379  GLU   A CA  1 
ATOM   733  C  C   . GLU   A 1 116 ? -11.897 -18.969 -36.979 0.50 34.77  ? 379  GLU   A C   1 
ATOM   734  O  O   . GLU   A 1 116 ? -13.095 -19.190 -37.287 0.50 33.49  ? 379  GLU   A O   1 
ATOM   735  C  CB  . GLU   A 1 116 ? -10.954 -16.684 -36.351 0.50 38.16  ? 379  GLU   A CB  1 
ATOM   736  C  CG  . GLU   A 1 116 ? -11.610 -16.116 -37.597 0.50 41.12  ? 379  GLU   A CG  1 
ATOM   737  C  CD  . GLU   A 1 116 ? -11.025 -14.778 -38.027 0.50 44.94  ? 379  GLU   A CD  1 
ATOM   738  O  OE1 . GLU   A 1 116 ? -10.621 -14.000 -37.125 0.50 46.78  ? 379  GLU   A OE1 1 
ATOM   739  O  OE2 . GLU   A 1 116 ? -10.951 -14.525 -39.255 0.50 46.40  ? 379  GLU   A OE2 1 
ATOM   740  N  N   . TRP   A 1 117 ? -10.853 -19.588 -37.539 1.00 32.17  ? 380  TRP   A N   1 
ATOM   741  C  CA  . TRP   A 1 117 ? -11.001 -20.574 -38.621 1.00 31.69  ? 380  TRP   A CA  1 
ATOM   742  C  C   . TRP   A 1 117 ? -11.858 -21.769 -38.125 1.00 32.75  ? 380  TRP   A C   1 
ATOM   743  O  O   . TRP   A 1 117 ? -12.730 -22.234 -38.867 1.00 29.06  ? 380  TRP   A O   1 
ATOM   744  C  CB  . TRP   A 1 117 ? -9.624  -21.028 -39.079 1.00 32.66  ? 380  TRP   A CB  1 
ATOM   745  C  CG  . TRP   A 1 117 ? -9.726  -22.054 -40.142 1.00 28.08  ? 380  TRP   A CG  1 
ATOM   746  C  CD1 . TRP   A 1 117 ? -9.870  -21.829 -41.478 1.00 28.38  ? 380  TRP   A CD1 1 
ATOM   747  C  CD2 . TRP   A 1 117 ? -9.702  -23.474 -39.959 1.00 34.01  ? 380  TRP   A CD2 1 
ATOM   748  N  NE1 . TRP   A 1 117 ? -9.898  -23.011 -42.138 1.00 34.28  ? 380  TRP   A NE1 1 
ATOM   749  C  CE2 . TRP   A 1 117 ? -9.816  -24.043 -41.238 1.00 33.83  ? 380  TRP   A CE2 1 
ATOM   750  C  CE3 . TRP   A 1 117 ? -9.553  -24.312 -38.852 1.00 32.46  ? 380  TRP   A CE3 1 
ATOM   751  C  CZ2 . TRP   A 1 117 ? -9.796  -25.421 -41.442 1.00 34.97  ? 380  TRP   A CZ2 1 
ATOM   752  C  CZ3 . TRP   A 1 117 ? -9.558  -25.671 -39.052 1.00 31.82  ? 380  TRP   A CZ3 1 
ATOM   753  C  CH2 . TRP   A 1 117 ? -9.684  -26.220 -40.321 1.00 31.40  ? 380  TRP   A CH2 1 
ATOM   754  N  N   . LEU   A 1 118 ? -11.636 -22.239 -36.896 1.00 30.96  ? 381  LEU   A N   1 
ATOM   755  C  CA  . LEU   A 1 118 ? -12.286 -23.497 -36.430 1.00 30.59  ? 381  LEU   A CA  1 
ATOM   756  C  C   . LEU   A 1 118 ? -13.779 -23.273 -36.154 1.00 27.57  ? 381  LEU   A C   1 
ATOM   757  O  O   . LEU   A 1 118 ? -14.584 -24.144 -36.553 1.00 26.77  ? 381  LEU   A O   1 
ATOM   758  C  CB  . LEU   A 1 118 ? -11.537 -24.005 -35.197 1.00 30.69  ? 381  LEU   A CB  1 
ATOM   759  C  CG  . LEU   A 1 118 ? -11.949 -25.409 -34.741 1.00 32.83  ? 381  LEU   A CG  1 
ATOM   760  C  CD1 . LEU   A 1 118 ? -11.681 -26.442 -35.814 1.00 33.29  ? 381  LEU   A CD1 1 
ATOM   761  C  CD2 . LEU   A 1 118 ? -11.217 -25.756 -33.455 1.00 34.37  ? 381  LEU   A CD2 1 
ATOM   762  N  N   . TRP   A 1 119 ? -14.164 -22.163 -35.520 1.00 28.53  ? 382  TRP   A N   1 
ATOM   763  C  CA  . TRP   A 1 119 ? -15.616 -21.859 -35.310 1.00 30.84  ? 382  TRP   A CA  1 
ATOM   764  C  C   . TRP   A 1 119 ? -16.314 -21.780 -36.670 1.00 33.70  ? 382  TRP   A C   1 
ATOM   765  O  O   . TRP   A 1 119 ? -17.387 -22.420 -36.831 1.00 32.50  ? 382  TRP   A O   1 
ATOM   766  C  CB  . TRP   A 1 119 ? -15.860 -20.613 -34.479 1.00 30.45  ? 382  TRP   A CB  1 
ATOM   767  C  CG  . TRP   A 1 119 ? -15.612 -20.781 -33.018 1.00 28.93  ? 382  TRP   A CG  1 
ATOM   768  C  CD1 . TRP   A 1 119 ? -14.799 -20.021 -32.257 1.00 29.43  ? 382  TRP   A CD1 1 
ATOM   769  C  CD2 . TRP   A 1 119 ? -16.234 -21.717 -32.112 1.00 27.87  ? 382  TRP   A CD2 1 
ATOM   770  N  NE1 . TRP   A 1 119 ? -14.834 -20.421 -30.951 1.00 27.59  ? 382  TRP   A NE1 1 
ATOM   771  C  CE2 . TRP   A 1 119 ? -15.688 -21.479 -30.838 1.00 26.21  ? 382  TRP   A CE2 1 
ATOM   772  C  CE3 . TRP   A 1 119 ? -17.164 -22.747 -32.250 1.00 28.15  ? 382  TRP   A CE3 1 
ATOM   773  C  CZ2 . TRP   A 1 119 ? -16.036 -22.210 -29.709 1.00 25.36  ? 382  TRP   A CZ2 1 
ATOM   774  C  CZ3 . TRP   A 1 119 ? -17.525 -23.458 -31.125 1.00 27.91  ? 382  TRP   A CZ3 1 
ATOM   775  C  CH2 . TRP   A 1 119 ? -16.964 -23.198 -29.879 1.00 24.71  ? 382  TRP   A CH2 1 
ATOM   776  N  N   . LYS   A 1 120 ? -15.680 -21.168 -37.681 1.00 33.63  ? 383  LYS   A N   1 
ATOM   777  C  CA  . LYS   A 1 120 ? -16.273 -21.148 -39.046 1.00 34.23  ? 383  LYS   A CA  1 
ATOM   778  C  C   . LYS   A 1 120 ? -16.456 -22.546 -39.612 1.00 33.00  ? 383  LYS   A C   1 
ATOM   779  O  O   . LYS   A 1 120 ? -17.561 -22.807 -40.139 1.00 31.06  ? 383  LYS   A O   1 
ATOM   780  C  CB  . LYS   A 1 120 ? -15.485 -20.316 -40.057 1.00 43.41  ? 383  LYS   A CB  1 
ATOM   781  C  CG  . LYS   A 1 120 ? -15.568 -18.819 -39.842 1.00 50.82  ? 383  LYS   A CG  1 
ATOM   782  C  CD  . LYS   A 1 120 ? -15.114 -18.016 -41.058 1.00 61.40  ? 383  LYS   A CD  1 
ATOM   783  C  CE  . LYS   A 1 120 ? -15.240 -16.521 -40.817 1.00 72.27  ? 383  LYS   A CE  1 
ATOM   784  N  NZ  . LYS   A 1 120 ? -14.026 -15.956 -40.180 1.00 78.05  ? 383  LYS   A NZ  1 
ATOM   785  N  N   . GLU   A 1 121 ? -15.464 -23.445 -39.557 1.00 29.66  ? 384  GLU   A N   1 
ATOM   786  C  CA  . GLU   A 1 121 ? -15.646 -24.823 -40.095 1.00 32.78  ? 384  GLU   A CA  1 
ATOM   787  C  C   . GLU   A 1 121 ? -16.761 -25.529 -39.330 1.00 30.23  ? 384  GLU   A C   1 
ATOM   788  O  O   . GLU   A 1 121 ? -17.525 -26.277 -39.964 1.00 33.81  ? 384  GLU   A O   1 
ATOM   789  C  CB  . GLU   A 1 121 ? -14.416 -25.731 -39.936 1.00 33.84  ? 384  GLU   A CB  1 
ATOM   790  C  CG  . GLU   A 1 121 ? -13.269 -25.306 -40.773 1.00 42.05  ? 384  GLU   A CG  1 
ATOM   791  C  CD  . GLU   A 1 121 ? -13.497 -25.317 -42.274 1.00 40.04  ? 384  GLU   A CD  1 
ATOM   792  O  OE1 . GLU   A 1 121 ? -13.955 -26.363 -42.847 1.00 41.22  ? 384  GLU   A OE1 1 
ATOM   793  O  OE2 . GLU   A 1 121 ? -13.148 -24.289 -42.859 1.00 44.90  ? 384  GLU   A OE2 1 
ATOM   794  N  N   . LEU   A 1 122 ? -16.779 -25.386 -37.999 1.00 30.94  ? 385  LEU   A N   1 
ATOM   795  C  CA  . LEU   A 1 122 ? -17.752 -26.131 -37.166 1.00 28.29  ? 385  LEU   A CA  1 
ATOM   796  C  C   . LEU   A 1 122 ? -19.163 -25.588 -37.500 1.00 30.54  ? 385  LEU   A C   1 
ATOM   797  O  O   . LEU   A 1 122 ? -20.127 -26.345 -37.351 1.00 26.86  ? 385  LEU   A O   1 
ATOM   798  C  CB  . LEU   A 1 122 ? -17.404 -25.960 -35.692 1.00 27.82  ? 385  LEU   A CB  1 
ATOM   799  C  CG  . LEU   A 1 122 ? -16.126 -26.683 -35.243 1.00 30.63  ? 385  LEU   A CG  1 
ATOM   800  C  CD1 . LEU   A 1 122 ? -15.811 -26.346 -33.798 1.00 32.69  ? 385  LEU   A CD1 1 
ATOM   801  C  CD2 . LEU   A 1 122 ? -16.274 -28.183 -35.444 1.00 29.84  ? 385  LEU   A CD2 1 
ATOM   802  N  N   . GLY   A 1 123 ? -19.240 -24.308 -37.885 1.00 31.02  ? 386  GLY   A N   1 
ATOM   803  C  CA  . GLY   A 1 123 ? -20.486 -23.558 -38.170 1.00 36.41  ? 386  GLY   A CA  1 
ATOM   804  C  C   . GLY   A 1 123 ? -20.984 -23.719 -39.607 1.00 42.34  ? 386  GLY   A C   1 
ATOM   805  O  O   . GLY   A 1 123 ? -22.148 -23.428 -39.832 1.00 39.64  ? 386  GLY   A O   1 
ATOM   806  N  N   . LYS   A 1 124 ? -20.183 -24.212 -40.555 1.00 38.79  ? 387  LYS   A N   1 
ATOM   807  C  CA  . LYS   A 1 124 ? -20.620 -24.343 -41.967 1.00 42.04  ? 387  LYS   A CA  1 
ATOM   808  C  C   . LYS   A 1 124 ? -21.925 -25.152 -42.083 1.00 42.87  ? 387  LYS   A C   1 
ATOM   809  O  O   . LYS   A 1 124 ? -22.788 -24.766 -42.873 1.00 40.22  ? 387  LYS   A O   1 
ATOM   810  C  CB  . LYS   A 1 124 ? -19.542 -24.981 -42.828 1.00 43.13  ? 387  LYS   A CB  1 
ATOM   811  C  CG  . LYS   A 1 124 ? -18.420 -24.063 -43.274 1.00 47.96  ? 387  LYS   A CG  1 
ATOM   812  C  CD  . LYS   A 1 124 ? -17.534 -24.752 -44.295 1.00 56.06  ? 387  LYS   A CD  1 
ATOM   813  C  CE  . LYS   A 1 124 ? -16.142 -24.169 -44.433 1.00 57.19  ? 387  LYS   A CE  1 
ATOM   814  N  NZ  . LYS   A 1 124 ? -15.240 -25.161 -45.085 1.00 65.00  ? 387  LYS   A NZ  1 
ATOM   815  N  N   . LYS   A 1 125 ? -22.077 -26.266 -41.378 1.00 35.99  ? 388  LYS   A N   1 
ATOM   816  C  CA  . LYS   A 1 125 ? -23.285 -27.102 -41.532 1.00 37.04  ? 388  LYS   A CA  1 
ATOM   817  C  C   . LYS   A 1 125 ? -24.153 -27.115 -40.272 1.00 31.56  ? 388  LYS   A C   1 
ATOM   818  O  O   . LYS   A 1 125 ? -24.923 -28.022 -40.146 1.00 35.20  ? 388  LYS   A O   1 
ATOM   819  C  CB  . LYS   A 1 125 ? -22.857 -28.504 -41.926 1.00 40.96  ? 388  LYS   A CB  1 
ATOM   820  C  CG  . LYS   A 1 125 ? -22.163 -28.589 -43.279 1.00 47.57  ? 388  LYS   A CG  1 
ATOM   821  C  CD  . LYS   A 1 125 ? -21.591 -29.991 -43.534 1.00 58.01  ? 388  LYS   A CD  1 
ATOM   822  C  CE  . LYS   A 1 125 ? -20.320 -30.277 -42.749 1.00 62.81  ? 388  LYS   A CE  1 
ATOM   823  N  NZ  . LYS   A 1 125 ? -20.135 -31.732 -42.516 1.00 71.23  ? 388  LYS   A NZ  1 
ATOM   824  N  N   . LYS   A 1 126 ? -24.021 -26.150 -39.371 1.00 30.22  ? 389  LYS   A N   1 
ATOM   825  C  CA  . LYS   A 1 126 ? -24.819 -26.117 -38.126 1.00 34.23  ? 389  LYS   A CA  1 
ATOM   826  C  C   . LYS   A 1 126 ? -25.308 -24.689 -37.933 1.00 37.37  ? 389  LYS   A C   1 
ATOM   827  O  O   . LYS   A 1 126 ? -24.615 -23.758 -38.390 1.00 42.54  ? 389  LYS   A O   1 
ATOM   828  C  CB  . LYS   A 1 126 ? -23.990 -26.473 -36.888 1.00 33.31  ? 389  LYS   A CB  1 
ATOM   829  C  CG  . LYS   A 1 126 ? -23.349 -27.847 -36.936 1.00 32.69  ? 389  LYS   A CG  1 
ATOM   830  C  CD  . LYS   A 1 126 ? -24.309 -28.898 -36.467 1.00 32.01  ? 389  LYS   A CD  1 
ATOM   831  C  CE  . LYS   A 1 126 ? -23.709 -30.273 -36.559 1.00 34.49  ? 389  LYS   A CE  1 
ATOM   832  N  NZ  . LYS   A 1 126 ? -24.755 -31.306 -36.481 1.00 33.61  ? 389  LYS   A NZ  1 
ATOM   833  N  N   . THR   A 1 127 ? -26.371 -24.538 -37.153 1.00 31.99  ? 390  THR   A N   1 
ATOM   834  C  CA  . THR   A 1 127 ? -26.945 -23.212 -36.786 1.00 34.08  ? 390  THR   A CA  1 
ATOM   835  C  C   . THR   A 1 127 ? -27.043 -23.068 -35.279 1.00 28.35  ? 390  THR   A C   1 
ATOM   836  O  O   . THR   A 1 127 ? -27.823 -23.768 -34.646 1.00 34.59  ? 390  THR   A O   1 
ATOM   837  C  CB  . THR   A 1 127 ? -28.354 -23.033 -37.392 1.00 40.23  ? 390  THR   A CB  1 
ATOM   838  O  OG1 . THR   A 1 127 ? -28.211 -23.221 -38.798 1.00 42.32  ? 390  THR   A OG1 1 
ATOM   839  C  CG2 . THR   A 1 127 ? -28.922 -21.670 -37.068 1.00 38.53  ? 390  THR   A CG2 1 
ATOM   840  N  N   . PRO   A 1 128 ? -26.306 -22.129 -34.664 1.00 29.11  ? 391  PRO   A N   1 
ATOM   841  C  CA  . PRO   A 1 128 ? -26.433 -21.890 -33.236 1.00 31.08  ? 391  PRO   A CA  1 
ATOM   842  C  C   . PRO   A 1 128 ? -27.877 -21.471 -32.919 1.00 36.00  ? 391  PRO   A C   1 
ATOM   843  O  O   . PRO   A 1 128 ? -28.501 -20.786 -33.724 1.00 35.02  ? 391  PRO   A O   1 
ATOM   844  C  CB  . PRO   A 1 128 ? -25.444 -20.768 -32.905 1.00 31.70  ? 391  PRO   A CB  1 
ATOM   845  C  CG  . PRO   A 1 128 ? -24.591 -20.617 -34.152 1.00 33.07  ? 391  PRO   A CG  1 
ATOM   846  C  CD  . PRO   A 1 128 ? -25.321 -21.243 -35.307 1.00 32.67  ? 391  PRO   A CD  1 
ATOM   847  N  N   . ARG   A 1 129 ? -28.373 -21.909 -31.770 1.00 33.55  ? 392  ARG   A N   1 
ATOM   848  C  CA  . ARG   A 1 129 ? -29.795 -21.738 -31.374 1.00 35.57  ? 392  ARG   A CA  1 
ATOM   849  C  C   . ARG   A 1 129 ? -29.905 -21.952 -29.862 1.00 45.29  ? 392  ARG   A C   1 
ATOM   850  O  O   . ARG   A 1 129 ? -29.042 -22.652 -29.273 1.00 35.19  ? 392  ARG   A O   1 
ATOM   851  C  CB  . ARG   A 1 129 ? -30.729 -22.634 -32.203 1.00 34.00  ? 392  ARG   A CB  1 
ATOM   852  C  CG  . ARG   A 1 129 ? -30.509 -24.143 -32.123 1.00 34.70  ? 392  ARG   A CG  1 
ATOM   853  C  CD  . ARG   A 1 129 ? -31.279 -24.802 -31.031 1.00 36.35  ? 392  ARG   A CD  1 
ATOM   854  N  NE  . ARG   A 1 129 ? -30.997 -26.214 -30.840 1.00 34.19  ? 392  ARG   A NE  1 
ATOM   855  C  CZ  . ARG   A 1 129 ? -31.572 -26.935 -29.903 1.00 34.52  ? 392  ARG   A CZ  1 
ATOM   856  N  NH1 . ARG   A 1 129 ? -32.521 -26.388 -29.174 1.00 36.30  ? 392  ARG   A NH1 1 
ATOM   857  N  NH2 . ARG   A 1 129 ? -31.303 -28.216 -29.772 1.00 37.45  ? 392  ARG   A NH2 1 
ATOM   858  N  N   . MET   A 1 130 ? -30.925 -21.345 -29.240 1.00 41.67  ? 393  MET   A N   1 
ATOM   859  C  CA  . MET   A 1 130 ? -31.190 -21.516 -27.798 1.00 41.94  ? 393  MET   A CA  1 
ATOM   860  C  C   . MET   A 1 130 ? -31.840 -22.860 -27.551 1.00 41.91  ? 393  MET   A C   1 
ATOM   861  O  O   . MET   A 1 130 ? -32.637 -23.319 -28.404 1.00 43.58  ? 393  MET   A O   1 
ATOM   862  C  CB  . MET   A 1 130 ? -32.100 -20.412 -27.265 1.00 50.60  ? 393  MET   A CB  1 
ATOM   863  C  CG  . MET   A 1 130 ? -31.406 -19.081 -27.178 1.00 50.81  ? 393  MET   A CG  1 
ATOM   864  S  SD  . MET   A 1 130 ? -32.403 -17.843 -26.297 1.00 62.01  ? 393  MET   A SD  1 
ATOM   865  C  CE  . MET   A 1 130 ? -33.862 -17.829 -27.342 1.00 61.55  ? 393  MET   A CE  1 
ATOM   866  N  N   . CYS   A 1 131 ? -31.479 -23.491 -26.439 1.00 38.96  ? 394  CYS   A N   1 
ATOM   867  C  CA  . CYS   A 1 131 ? -32.137 -24.711 -25.933 1.00 42.21  ? 394  CYS   A CA  1 
ATOM   868  C  C   . CYS   A 1 131 ? -33.292 -24.286 -25.007 1.00 41.91  ? 394  CYS   A C   1 
ATOM   869  O  O   . CYS   A 1 131 ? -33.270 -23.161 -24.525 1.00 42.36  ? 394  CYS   A O   1 
ATOM   870  C  CB  . CYS   A 1 131 ? -31.149 -25.638 -25.252 1.00 42.07  ? 394  CYS   A CB  1 
ATOM   871  S  SG  . CYS   A 1 131 ? -29.972 -26.377 -26.411 1.00 41.65  ? 394  CYS   A SG  1 
ATOM   872  N  N   . THR   A 1 132 ? -34.315 -25.123 -24.877 1.00 44.10  ? 395  THR   A N   1 
ATOM   873  C  CA  . THR   A 1 132 ? -35.660 -24.705 -24.389 1.00 50.29  ? 395  THR   A CA  1 
ATOM   874  C  C   . THR   A 1 132 ? -35.864 -25.180 -22.949 1.00 45.40  ? 395  THR   A C   1 
ATOM   875  O  O   . THR   A 1 132 ? -35.260 -26.200 -22.568 1.00 48.21  ? 395  THR   A O   1 
ATOM   876  C  CB  . THR   A 1 132 ? -36.756 -25.264 -25.313 1.00 44.62  ? 395  THR   A CB  1 
ATOM   877  O  OG1 . THR   A 1 132 ? -36.765 -26.690 -25.217 1.00 54.53  ? 395  THR   A OG1 1 
ATOM   878  C  CG2 . THR   A 1 132 ? -36.555 -24.907 -26.769 1.00 53.24  ? 395  THR   A CG2 1 
ATOM   879  N  N   . ARG   A 1 133 ? -36.768 -24.528 -22.219 1.00 56.98  ? 396  ARG   A N   1 
ATOM   880  C  CA  . ARG   A 1 133 ? -37.299 -25.039 -20.922 1.00 55.92  ? 396  ARG   A CA  1 
ATOM   881  C  C   . ARG   A 1 133 ? -37.729 -26.497 -21.087 1.00 63.08  ? 396  ARG   A C   1 
ATOM   882  O  O   . ARG   A 1 133 ? -37.367 -27.341 -20.234 1.00 65.69  ? 396  ARG   A O   1 
ATOM   883  C  CB  . ARG   A 1 133 ? -38.436 -24.145 -20.426 1.00 60.20  ? 396  ARG   A CB  1 
ATOM   884  C  CG  . ARG   A 1 133 ? -38.060 -22.676 -20.432 1.00 59.74  ? 396  ARG   A CG  1 
ATOM   885  C  CD  . ARG   A 1 133 ? -38.802 -21.816 -19.430 1.00 65.28  ? 396  ARG   A CD  1 
ATOM   886  N  NE  . ARG   A 1 133 ? -38.098 -20.554 -19.243 1.00 64.70  ? 396  ARG   A NE  1 
ATOM   887  C  CZ  . ARG   A 1 133 ? -38.473 -19.581 -18.415 1.00 76.12  ? 396  ARG   A CZ  1 
ATOM   888  N  NH1 . ARG   A 1 133 ? -39.590 -19.696 -17.714 1.00 80.60  ? 396  ARG   A NH1 1 
ATOM   889  N  NH2 . ARG   A 1 133 ? -37.737 -18.486 -18.311 1.00 67.65  ? 396  ARG   A NH2 1 
ATOM   890  N  N   . GLU   A 1 134 ? -38.459 -26.786 -22.171 0.50 64.12  ? 397  GLU   A N   1 
ATOM   891  C  CA  . GLU   A 1 134 ? -39.005 -28.130 -22.503 0.50 66.95  ? 397  GLU   A CA  1 
ATOM   892  C  C   . GLU   A 1 134 ? -37.862 -29.149 -22.582 0.50 63.37  ? 397  GLU   A C   1 
ATOM   893  O  O   . GLU   A 1 134 ? -38.008 -30.241 -22.001 0.50 63.72  ? 397  GLU   A O   1 
ATOM   894  C  CB  . GLU   A 1 134 ? -39.785 -28.074 -23.820 0.50 73.07  ? 397  GLU   A CB  1 
ATOM   895  C  CG  . GLU   A 1 134 ? -41.036 -27.208 -23.762 0.50 78.62  ? 397  GLU   A CG  1 
ATOM   896  C  CD  . GLU   A 1 134 ? -40.804 -25.720 -23.539 0.50 83.76  ? 397  GLU   A CD  1 
ATOM   897  O  OE1 . GLU   A 1 134 ? -39.630 -25.304 -23.485 0.50 83.27  ? 397  GLU   A OE1 1 
ATOM   898  O  OE2 . GLU   A 1 134 ? -41.805 -24.976 -23.416 0.50 87.36  ? 397  GLU   A OE2 1 
ATOM   899  N  N   . GLU   A 1 135 ? -36.767 -28.805 -23.272 0.50 61.64  ? 398  GLU   A N   1 
ATOM   900  C  CA  . GLU   A 1 135 ? -35.587 -29.695 -23.462 0.50 58.68  ? 398  GLU   A CA  1 
ATOM   901  C  C   . GLU   A 1 135 ? -34.882 -29.913 -22.119 0.50 57.94  ? 398  GLU   A C   1 
ATOM   902  O  O   . GLU   A 1 135 ? -34.419 -31.044 -21.871 0.50 56.49  ? 398  GLU   A O   1 
ATOM   903  C  CB  . GLU   A 1 135 ? -34.609 -29.107 -24.482 0.50 55.42  ? 398  GLU   A CB  1 
ATOM   904  C  CG  . GLU   A 1 135 ? -34.886 -29.554 -25.904 0.50 52.56  ? 398  GLU   A CG  1 
ATOM   905  C  CD  . GLU   A 1 135 ? -33.956 -28.957 -26.947 0.50 49.52  ? 398  GLU   A CD  1 
ATOM   906  O  OE1 . GLU   A 1 135 ? -33.634 -27.754 -26.826 0.50 40.93  ? 398  GLU   A OE1 1 
ATOM   907  O  OE2 . GLU   A 1 135 ? -33.559 -29.702 -27.877 0.50 44.21  ? 398  GLU   A OE2 1 
ATOM   908  N  N   . PHE   A 1 136 ? -34.770 -28.858 -21.308 0.50 59.63  ? 399  PHE   A N   1 
ATOM   909  C  CA  . PHE   A 1 136 ? -34.173 -28.901 -19.948 0.50 61.26  ? 399  PHE   A CA  1 
ATOM   910  C  C   . PHE   A 1 136 ? -35.060 -29.756 -19.035 0.50 62.22  ? 399  PHE   A C   1 
ATOM   911  O  O   . PHE   A 1 136 ? -34.539 -30.694 -18.389 0.50 58.51  ? 399  PHE   A O   1 
ATOM   912  C  CB  . PHE   A 1 136 ? -33.999 -27.487 -19.390 0.50 60.33  ? 399  PHE   A CB  1 
ATOM   913  C  CG  . PHE   A 1 136 ? -33.175 -27.430 -18.130 0.50 58.74  ? 399  PHE   A CG  1 
ATOM   914  C  CD1 . PHE   A 1 136 ? -31.805 -27.626 -18.174 0.50 56.81  ? 399  PHE   A CD1 1 
ATOM   915  C  CD2 . PHE   A 1 136 ? -33.770 -27.193 -16.902 0.50 58.69  ? 399  PHE   A CD2 1 
ATOM   916  C  CE1 . PHE   A 1 136 ? -31.045 -27.577 -17.018 0.50 57.55  ? 399  PHE   A CE1 1 
ATOM   917  C  CE2 . PHE   A 1 136 ? -33.009 -27.145 -15.746 0.50 59.19  ? 399  PHE   A CE2 1 
ATOM   918  C  CZ  . PHE   A 1 136 ? -31.649 -27.341 -15.806 0.50 58.73  ? 399  PHE   A CZ  1 
ATOM   919  N  N   . THR   A 1 137 ? -36.361 -29.436 -19.002 1.00 63.99  ? 400  THR   A N   1 
ATOM   920  C  CA  . THR   A 1 137 ? -37.391 -30.152 -18.192 1.00 69.22  ? 400  THR   A CA  1 
ATOM   921  C  C   . THR   A 1 137 ? -37.418 -31.645 -18.527 1.00 71.97  ? 400  THR   A C   1 
ATOM   922  O  O   . THR   A 1 137 ? -37.597 -32.462 -17.633 1.00 72.02  ? 400  THR   A O   1 
ATOM   923  C  CB  . THR   A 1 137 ? -38.777 -29.540 -18.416 1.00 68.44  ? 400  THR   A CB  1 
ATOM   924  O  OG1 . THR   A 1 137 ? -38.729 -28.245 -17.821 1.00 68.13  ? 400  THR   A OG1 1 
ATOM   925  C  CG2 . THR   A 1 137 ? -39.910 -30.357 -17.835 1.00 72.80  ? 400  THR   A CG2 1 
ATOM   926  N  N   . ARG   A 1 138 ? -37.246 -31.980 -19.807 0.50 75.54  ? 401  ARG   A N   1 
ATOM   927  C  CA  . ARG   A 1 138 ? -37.229 -33.382 -20.294 0.50 77.27  ? 401  ARG   A CA  1 
ATOM   928  C  C   . ARG   A 1 138 ? -35.948 -34.060 -19.796 0.50 76.42  ? 401  ARG   A C   1 
ATOM   929  O  O   . ARG   A 1 138 ? -36.029 -35.215 -19.343 0.50 76.39  ? 401  ARG   A O   1 
ATOM   930  C  CB  . ARG   A 1 138 ? -37.350 -33.407 -21.821 0.50 83.45  ? 401  ARG   A CB  1 
ATOM   931  C  CG  . ARG   A 1 138 ? -37.681 -34.777 -22.398 0.50 86.31  ? 401  ARG   A CG  1 
ATOM   932  C  CD  . ARG   A 1 138 ? -38.464 -34.681 -23.695 0.50 87.89  ? 401  ARG   A CD  1 
ATOM   933  N  NE  . ARG   A 1 138 ? -37.794 -33.845 -24.681 0.50 91.10  ? 401  ARG   A NE  1 
ATOM   934  C  CZ  . ARG   A 1 138 ? -37.148 -34.300 -25.751 0.50 91.14  ? 401  ARG   A CZ  1 
ATOM   935  N  NH1 . ARG   A 1 138 ? -37.089 -35.600 -25.988 0.50 90.74  ? 401  ARG   A NH1 1 
ATOM   936  N  NH2 . ARG   A 1 138 ? -36.569 -33.451 -26.583 0.50 87.72  ? 401  ARG   A NH2 1 
ATOM   937  N  N   . LYS   A 1 139 ? -34.817 -33.351 -19.846 0.50 76.51  ? 402  LYS   A N   1 
ATOM   938  C  CA  . LYS   A 1 139 ? -33.482 -33.875 -19.449 0.50 78.07  ? 402  LYS   A CA  1 
ATOM   939  C  C   . LYS   A 1 139 ? -33.463 -34.155 -17.939 0.50 80.89  ? 402  LYS   A C   1 
ATOM   940  O  O   . LYS   A 1 139 ? -32.796 -35.132 -17.531 0.50 82.45  ? 402  LYS   A O   1 
ATOM   941  C  CB  . LYS   A 1 139 ? -32.381 -32.888 -19.852 0.50 78.00  ? 402  LYS   A CB  1 
ATOM   942  C  CG  . LYS   A 1 139 ? -32.147 -32.760 -21.354 0.50 77.77  ? 402  LYS   A CG  1 
ATOM   943  C  CD  . LYS   A 1 139 ? -30.993 -31.843 -21.721 0.50 77.69  ? 402  LYS   A CD  1 
ATOM   944  C  CE  . LYS   A 1 139 ? -29.635 -32.398 -21.344 0.50 77.87  ? 402  LYS   A CE  1 
ATOM   945  N  NZ  . LYS   A 1 139 ? -29.260 -33.558 -22.188 0.50 76.61  ? 402  LYS   A NZ  1 
ATOM   946  N  N   . VAL   A 1 140 ? -34.161 -33.339 -17.140 0.50 81.55  ? 403  VAL   A N   1 
ATOM   947  C  CA  . VAL   A 1 140 ? -34.198 -33.465 -15.650 0.50 84.01  ? 403  VAL   A CA  1 
ATOM   948  C  C   . VAL   A 1 140 ? -35.204 -34.558 -15.260 0.50 87.11  ? 403  VAL   A C   1 
ATOM   949  O  O   . VAL   A 1 140 ? -34.974 -35.214 -14.222 0.50 86.78  ? 403  VAL   A O   1 
ATOM   950  C  CB  . VAL   A 1 140 ? -34.517 -32.125 -14.955 0.50 84.25  ? 403  VAL   A CB  1 
ATOM   951  C  CG1 . VAL   A 1 140 ? -33.634 -30.995 -15.460 0.50 83.02  ? 403  VAL   A CG1 1 
ATOM   952  C  CG2 . VAL   A 1 140 ? -35.983 -31.748 -15.076 0.50 86.17  ? 403  VAL   A CG2 1 
ATOM   953  N  N   . ARG   A 1 141 ? -36.261 -34.749 -16.062 1.00 88.84  ? 404  ARG   A N   1 
ATOM   954  C  CA  . ARG   A 1 141 ? -37.296 -35.813 -15.846 1.00 89.75  ? 404  ARG   A CA  1 
ATOM   955  C  C   . ARG   A 1 141 ? -36.852 -37.169 -16.429 1.00 93.80  ? 404  ARG   A C   1 
ATOM   956  O  O   . ARG   A 1 141 ? -37.687 -38.092 -16.428 1.00 106.31 ? 404  ARG   A O   1 
ATOM   957  C  CB  . ARG   A 1 141 ? -38.658 -35.395 -16.418 1.00 85.13  ? 404  ARG   A CB  1 
ATOM   958  C  CG  . ARG   A 1 141 ? -39.359 -34.313 -15.606 1.00 87.81  ? 404  ARG   A CG  1 
ATOM   959  C  CD  . ARG   A 1 141 ? -40.863 -34.491 -15.493 1.00 92.53  ? 404  ARG   A CD  1 
ATOM   960  N  NE  . ARG   A 1 141 ? -41.619 -34.004 -16.647 1.00 97.09  ? 404  ARG   A NE  1 
ATOM   961  C  CZ  . ARG   A 1 141 ? -42.201 -32.802 -16.754 1.00 99.64  ? 404  ARG   A CZ  1 
ATOM   962  N  NH1 . ARG   A 1 141 ? -42.116 -31.914 -15.774 1.00 96.55  ? 404  ARG   A NH1 1 
ATOM   963  N  NH2 . ARG   A 1 141 ? -42.869 -32.486 -17.854 1.00 102.49 ? 404  ARG   A NH2 1 
ATOM   964  N  N   . SER   A 1 142 ? -35.601 -37.304 -16.893 1.00 94.70  ? 405  SER   A N   1 
ATOM   965  C  CA  . SER   A 1 142 ? -34.975 -38.589 -17.307 1.00 102.66 ? 405  SER   A CA  1 
ATOM   966  C  C   . SER   A 1 142 ? -33.561 -38.737 -16.715 1.00 102.08 ? 405  SER   A C   1 
ATOM   967  O  O   . SER   A 1 142 ? -32.811 -39.588 -17.225 1.00 97.94  ? 405  SER   A O   1 
ATOM   968  C  CB  . SER   A 1 142 ? -34.968 -38.723 -18.822 1.00 111.57 ? 405  SER   A CB  1 
ATOM   969  O  OG  . SER   A 1 142 ? -34.641 -37.492 -19.456 1.00 116.73 ? 405  SER   A OG  1 
ATOM   970  N  N   . ASN   A 1 143 ? -33.207 -37.940 -15.695 1.00 107.70 ? 406  ASN   A N   1 
ATOM   971  C  CA  . ASN   A 1 143 ? -31.984 -38.082 -14.848 1.00 115.54 ? 406  ASN   A CA  1 
ATOM   972  C  C   . ASN   A 1 143 ? -30.701 -38.136 -15.692 1.00 114.75 ? 406  ASN   A C   1 
ATOM   973  O  O   . ASN   A 1 143 ? -30.435 -39.194 -16.292 1.00 118.42 ? 406  ASN   A O   1 
ATOM   974  C  CB  . ASN   A 1 143 ? -32.017 -39.339 -13.970 1.00 118.66 ? 406  ASN   A CB  1 
ATOM   975  C  CG  . ASN   A 1 143 ? -33.339 -39.563 -13.268 1.00 124.51 ? 406  ASN   A CG  1 
ATOM   976  O  OD1 . ASN   A 1 143 ? -34.269 -38.771 -13.401 1.00 125.26 ? 406  ASN   A OD1 1 
ATOM   977  N  ND2 . ASN   A 1 143 ? -33.438 -40.657 -12.531 1.00 128.75 ? 406  ASN   A ND2 1 
ATOM   978  N  N   . ALA   A 1 144 ? -29.901 -37.066 -15.668 1.00 118.84 ? 407  ALA   A N   1 
ATOM   979  C  CA  . ALA   A 1 144 ? -28.544 -36.992 -16.268 1.00 121.13 ? 407  ALA   A CA  1 
ATOM   980  C  C   . ALA   A 1 144 ? -27.610 -36.238 -15.307 1.00 128.45 ? 407  ALA   A C   1 
ATOM   981  O  O   . ALA   A 1 144 ? -28.066 -35.805 -14.234 1.00 135.03 ? 407  ALA   A O   1 
ATOM   982  C  CB  . ALA   A 1 144 ? -28.631 -36.320 -17.619 1.00 110.47 ? 407  ALA   A CB  1 
ATOM   983  N  N   . ALA   A 1 145 ? -26.337 -36.089 -15.693 0.50 123.11 ? 408  ALA   A N   1 
ATOM   984  C  CA  . ALA   A 1 145 ? -25.318 -35.273 -14.990 0.50 117.28 ? 408  ALA   A CA  1 
ATOM   985  C  C   . ALA   A 1 145 ? -25.580 -33.788 -15.273 0.50 113.27 ? 408  ALA   A C   1 
ATOM   986  O  O   . ALA   A 1 145 ? -25.374 -33.362 -16.427 0.50 112.76 ? 408  ALA   A O   1 
ATOM   987  C  CB  . ALA   A 1 145 ? -23.935 -35.687 -15.431 0.50 116.79 ? 408  ALA   A CB  1 
ATOM   988  N  N   . LEU   A 1 146 ? -26.016 -33.037 -14.255 0.50 107.93 ? 409  LEU   A N   1 
ATOM   989  C  CA  . LEU   A 1 146 ? -26.464 -31.622 -14.376 0.50 102.78 ? 409  LEU   A CA  1 
ATOM   990  C  C   . LEU   A 1 146 ? -25.581 -30.715 -13.511 0.50 97.02  ? 409  LEU   A C   1 
ATOM   991  O  O   . LEU   A 1 146 ? -25.633 -29.482 -13.706 0.50 94.77  ? 409  LEU   A O   1 
ATOM   992  C  CB  . LEU   A 1 146 ? -27.932 -31.535 -13.945 0.50 103.70 ? 409  LEU   A CB  1 
ATOM   993  C  CG  . LEU   A 1 146 ? -28.902 -32.389 -14.758 0.50 104.67 ? 409  LEU   A CG  1 
ATOM   994  C  CD1 . LEU   A 1 146 ? -30.252 -32.493 -14.063 0.50 104.43 ? 409  LEU   A CD1 1 
ATOM   995  C  CD2 . LEU   A 1 146 ? -29.061 -31.836 -16.167 0.50 105.40 ? 409  LEU   A CD2 1 
ATOM   996  N  N   . GLY   A 1 147 ? -24.813 -31.306 -12.590 0.50 90.43  ? 410  GLY   A N   1 
ATOM   997  C  CA  . GLY   A 1 147 ? -23.916 -30.589 -11.662 0.50 85.81  ? 410  GLY   A CA  1 
ATOM   998  C  C   . GLY   A 1 147 ? -24.656 -29.526 -10.866 0.50 81.83  ? 410  GLY   A C   1 
ATOM   999  O  O   . GLY   A 1 147 ? -24.077 -28.443 -10.652 0.50 75.92  ? 410  GLY   A O   1 
ATOM   1000 N  N   . ALA   A 1 148 ? -25.889 -29.825 -10.440 0.50 81.40  ? 411  ALA   A N   1 
ATOM   1001 C  CA  . ALA   A 1 148 ? -26.765 -28.929 -9.648  0.50 82.31  ? 411  ALA   A CA  1 
ATOM   1002 C  C   . ALA   A 1 148 ? -26.706 -29.326 -8.167  0.50 83.12  ? 411  ALA   A C   1 
ATOM   1003 O  O   . ALA   A 1 148 ? -26.472 -30.516 -7.885  0.50 80.59  ? 411  ALA   A O   1 
ATOM   1004 C  CB  . ALA   A 1 148 ? -28.177 -28.991 -10.177 0.50 79.86  ? 411  ALA   A CB  1 
ATOM   1005 N  N   . ILE   A 1 149 ? -26.914 -28.357 -7.269  0.50 85.49  ? 412  ILE   A N   1 
ATOM   1006 C  CA  . ILE   A 1 149 ? -26.935 -28.551 -5.787  0.50 87.20  ? 412  ILE   A CA  1 
ATOM   1007 C  C   . ILE   A 1 149 ? -28.385 -28.771 -5.342  0.50 89.73  ? 412  ILE   A C   1 
ATOM   1008 O  O   . ILE   A 1 149 ? -29.194 -27.846 -5.560  0.50 92.87  ? 412  ILE   A O   1 
ATOM   1009 C  CB  . ILE   A 1 149 ? -26.291 -27.349 -5.064  0.50 85.96  ? 412  ILE   A CB  1 
ATOM   1010 C  CG1 . ILE   A 1 149 ? -27.012 -26.038 -5.389  0.50 85.77  ? 412  ILE   A CG1 1 
ATOM   1011 C  CG2 . ILE   A 1 149 ? -24.804 -27.267 -5.375  0.50 86.54  ? 412  ILE   A CG2 1 
ATOM   1012 C  CD1 . ILE   A 1 149 ? -26.386 -24.814 -4.757  0.50 85.29  ? 412  ILE   A CD1 1 
ATOM   1013 N  N   . LYS   A 1 155 ? -36.130 -24.346 -0.806  0.50 75.06  ? 418  LYS   A N   1 
ATOM   1014 C  CA  . LYS   A 1 155 ? -37.497 -24.116 -1.350  0.50 74.06  ? 418  LYS   A CA  1 
ATOM   1015 C  C   . LYS   A 1 155 ? -37.940 -25.359 -2.137  0.50 71.55  ? 418  LYS   A C   1 
ATOM   1016 O  O   . LYS   A 1 155 ? -39.146 -25.684 -2.101  0.50 71.55  ? 418  LYS   A O   1 
ATOM   1017 C  CB  . LYS   A 1 155 ? -37.513 -22.841 -2.203  0.50 74.06  ? 418  LYS   A CB  1 
ATOM   1018 C  CG  . LYS   A 1 155 ? -38.862 -22.480 -2.815  0.50 74.39  ? 418  LYS   A CG  1 
ATOM   1019 C  CD  . LYS   A 1 155 ? -40.008 -22.489 -1.823  0.50 74.46  ? 418  LYS   A CD  1 
ATOM   1020 C  CE  . LYS   A 1 155 ? -41.361 -22.659 -2.483  0.50 76.05  ? 418  LYS   A CE  1 
ATOM   1021 N  NZ  . LYS   A 1 155 ? -42.406 -23.021 -1.497  0.50 75.33  ? 418  LYS   A NZ  1 
ATOM   1022 N  N   . TRP   A 1 156 ? -36.996 -26.027 -2.812  0.50 69.26  ? 419  TRP   A N   1 
ATOM   1023 C  CA  . TRP   A 1 156 ? -37.213 -27.290 -3.572  0.50 69.04  ? 419  TRP   A CA  1 
ATOM   1024 C  C   . TRP   A 1 156 ? -36.176 -28.329 -3.138  0.50 71.53  ? 419  TRP   A C   1 
ATOM   1025 O  O   . TRP   A 1 156 ? -35.099 -27.927 -2.656  0.50 70.96  ? 419  TRP   A O   1 
ATOM   1026 C  CB  . TRP   A 1 156 ? -37.142 -27.044 -5.088  0.50 66.14  ? 419  TRP   A CB  1 
ATOM   1027 C  CG  . TRP   A 1 156 ? -38.030 -25.934 -5.552  0.50 60.24  ? 419  TRP   A CG  1 
ATOM   1028 C  CD1 . TRP   A 1 156 ? -39.376 -25.994 -5.767  0.50 58.44  ? 419  TRP   A CD1 1 
ATOM   1029 C  CD2 . TRP   A 1 156 ? -37.638 -24.576 -5.822  0.50 57.64  ? 419  TRP   A CD2 1 
ATOM   1030 N  NE1 . TRP   A 1 156 ? -39.848 -24.771 -6.161  0.50 57.91  ? 419  TRP   A NE1 1 
ATOM   1031 C  CE2 . TRP   A 1 156 ? -38.805 -23.883 -6.205  0.50 56.70  ? 419  TRP   A CE2 1 
ATOM   1032 C  CE3 . TRP   A 1 156 ? -36.422 -23.885 -5.787  0.50 57.32  ? 419  TRP   A CE3 1 
ATOM   1033 C  CZ2 . TRP   A 1 156 ? -38.786 -22.533 -6.547  0.50 56.83  ? 419  TRP   A CZ2 1 
ATOM   1034 C  CZ3 . TRP   A 1 156 ? -36.405 -22.551 -6.125  0.50 57.30  ? 419  TRP   A CZ3 1 
ATOM   1035 C  CH2 . TRP   A 1 156 ? -37.572 -21.887 -6.498  0.50 57.87  ? 419  TRP   A CH2 1 
ATOM   1036 N  N   . LYS   A 1 157 ? -36.488 -29.613 -3.329  0.50 76.31  ? 420  LYS   A N   1 
ATOM   1037 C  CA  . LYS   A 1 157 ? -35.595 -30.754 -2.998  0.50 79.73  ? 420  LYS   A CA  1 
ATOM   1038 C  C   . LYS   A 1 157 ? -34.856 -31.204 -4.264  0.50 82.15  ? 420  LYS   A C   1 
ATOM   1039 O  O   . LYS   A 1 157 ? -33.763 -30.665 -4.539  0.50 86.33  ? 420  LYS   A O   1 
ATOM   1040 C  CB  . LYS   A 1 157 ? -36.417 -31.901 -2.404  0.50 80.28  ? 420  LYS   A CB  1 
ATOM   1041 C  CG  . LYS   A 1 157 ? -35.659 -33.204 -2.189  0.50 80.09  ? 420  LYS   A CG  1 
ATOM   1042 C  CD  . LYS   A 1 157 ? -36.572 -34.408 -2.118  0.50 80.46  ? 420  LYS   A CD  1 
ATOM   1043 C  CE  . LYS   A 1 157 ? -37.834 -34.137 -1.325  0.50 78.79  ? 420  LYS   A CE  1 
ATOM   1044 N  NZ  . LYS   A 1 157 ? -38.829 -35.223 -1.487  0.50 77.09  ? 420  LYS   A NZ  1 
ATOM   1045 N  N   . SER   A 1 158 ? -35.444 -32.155 -4.997  0.50 81.04  ? 421  SER   A N   1 
ATOM   1046 C  CA  . SER   A 1 158 ? -34.912 -32.724 -6.263  0.50 78.86  ? 421  SER   A CA  1 
ATOM   1047 C  C   . SER   A 1 158 ? -35.050 -31.698 -7.391  0.50 79.15  ? 421  SER   A C   1 
ATOM   1048 O  O   . SER   A 1 158 ? -35.735 -30.670 -7.187  0.50 78.07  ? 421  SER   A O   1 
ATOM   1049 C  CB  . SER   A 1 158 ? -35.611 -34.012 -6.610  0.50 77.45  ? 421  SER   A CB  1 
ATOM   1050 O  OG  . SER   A 1 158 ? -37.005 -33.801 -6.767  0.50 80.60  ? 421  SER   A OG  1 
ATOM   1051 N  N   . ALA   A 1 159 ? -34.425 -31.975 -8.538  0.50 78.64  ? 422  ALA   A N   1 
ATOM   1052 C  CA  . ALA   A 1 159 ? -34.483 -31.140 -9.759  0.50 75.80  ? 422  ALA   A CA  1 
ATOM   1053 C  C   . ALA   A 1 159 ? -35.933 -31.062 -10.249 0.50 73.24  ? 422  ALA   A C   1 
ATOM   1054 O  O   . ALA   A 1 159 ? -36.410 -29.942 -10.518 0.50 69.17  ? 422  ALA   A O   1 
ATOM   1055 C  CB  . ALA   A 1 159 ? -33.569 -31.711 -10.814 0.50 78.46  ? 422  ALA   A CB  1 
ATOM   1056 N  N   . ARG   A 1 160 ? -36.607 -32.212 -10.340 0.50 72.19  ? 423  ARG   A N   1 
ATOM   1057 C  CA  . ARG   A 1 160 ? -38.005 -32.321 -10.833 0.50 74.92  ? 423  ARG   A CA  1 
ATOM   1058 C  C   . ARG   A 1 160 ? -38.868 -31.247 -10.154 0.50 78.53  ? 423  ARG   A C   1 
ATOM   1059 O  O   . ARG   A 1 160 ? -39.470 -30.431 -10.885 0.50 77.84  ? 423  ARG   A O   1 
ATOM   1060 C  CB  . ARG   A 1 160 ? -38.543 -33.736 -10.595 0.50 76.63  ? 423  ARG   A CB  1 
ATOM   1061 C  CG  . ARG   A 1 160 ? -38.008 -34.778 -11.567 0.50 79.58  ? 423  ARG   A CG  1 
ATOM   1062 C  CD  . ARG   A 1 160 ? -38.605 -36.154 -11.326 0.50 81.11  ? 423  ARG   A CD  1 
ATOM   1063 N  NE  . ARG   A 1 160 ? -38.250 -37.134 -12.344 0.50 82.16  ? 423  ARG   A NE  1 
ATOM   1064 C  CZ  . ARG   A 1 160 ? -37.133 -37.854 -12.339 0.50 81.25  ? 423  ARG   A CZ  1 
ATOM   1065 N  NH1 . ARG   A 1 160 ? -36.249 -37.693 -11.370 0.50 80.27  ? 423  ARG   A NH1 1 
ATOM   1066 N  NH2 . ARG   A 1 160 ? -36.902 -38.726 -13.306 0.50 80.12  ? 423  ARG   A NH2 1 
ATOM   1067 N  N   . GLU   A 1 161 ? -38.934 -31.256 -8.820  0.50 77.23  ? 424  GLU   A N   1 
ATOM   1068 C  CA  . GLU   A 1 161 ? -39.824 -30.312 -8.092  0.50 77.52  ? 424  GLU   A CA  1 
ATOM   1069 C  C   . GLU   A 1 161 ? -39.643 -28.888 -8.621  0.50 74.15  ? 424  GLU   A C   1 
ATOM   1070 O  O   . GLU   A 1 161 ? -40.659 -28.259 -8.965  0.50 71.70  ? 424  GLU   A O   1 
ATOM   1071 C  CB  . GLU   A 1 161 ? -39.533 -30.354 -6.592  0.50 79.96  ? 424  GLU   A CB  1 
ATOM   1072 C  CG  . GLU   A 1 161 ? -39.553 -31.755 -6.013  0.50 81.53  ? 424  GLU   A CG  1 
ATOM   1073 C  CD  . GLU   A 1 161 ? -39.175 -31.833 -4.544  0.50 81.80  ? 424  GLU   A CD  1 
ATOM   1074 O  OE1 . GLU   A 1 161 ? -38.958 -30.767 -3.933  0.50 78.56  ? 424  GLU   A OE1 1 
ATOM   1075 O  OE2 . GLU   A 1 161 ? -39.098 -32.959 -4.016  0.50 81.14  ? 424  GLU   A OE2 1 
ATOM   1076 N  N   . ALA   A 1 162 ? -38.402 -28.399 -8.667  0.50 70.98  ? 425  ALA   A N   1 
ATOM   1077 C  CA  . ALA   A 1 162 ? -38.161 -27.001 -9.090  0.50 70.45  ? 425  ALA   A CA  1 
ATOM   1078 C  C   . ALA   A 1 162 ? -38.690 -26.802 -10.511 0.50 69.15  ? 425  ALA   A C   1 
ATOM   1079 O  O   . ALA   A 1 162 ? -39.365 -25.787 -10.751 0.50 66.78  ? 425  ALA   A O   1 
ATOM   1080 C  CB  . ALA   A 1 162 ? -36.689 -26.692 -9.000  0.50 69.38  ? 425  ALA   A CB  1 
ATOM   1081 N  N   . VAL   A 1 163 ? -38.400 -27.747 -11.404 0.50 69.60  ? 426  VAL   A N   1 
ATOM   1082 C  CA  . VAL   A 1 163 ? -38.843 -27.646 -12.825 0.50 73.43  ? 426  VAL   A CA  1 
ATOM   1083 C  C   . VAL   A 1 163 ? -40.370 -27.598 -12.856 0.50 75.25  ? 426  VAL   A C   1 
ATOM   1084 O  O   . VAL   A 1 163 ? -40.920 -26.855 -13.688 0.50 73.24  ? 426  VAL   A O   1 
ATOM   1085 C  CB  . VAL   A 1 163 ? -38.298 -28.829 -13.646 0.50 74.06  ? 426  VAL   A CB  1 
ATOM   1086 C  CG1 . VAL   A 1 163 ? -39.182 -29.155 -14.835 0.50 76.64  ? 426  VAL   A CG1 1 
ATOM   1087 C  CG2 . VAL   A 1 163 ? -36.859 -28.600 -14.078 0.50 74.80  ? 426  VAL   A CG2 1 
ATOM   1088 N  N   . GLU   A 1 164 ? -41.017 -28.364 -11.976 0.50 80.70  ? 427  GLU   A N   1 
ATOM   1089 C  CA  . GLU   A 1 164 ? -42.500 -28.384 -11.910 0.50 83.79  ? 427  GLU   A CA  1 
ATOM   1090 C  C   . GLU   A 1 164 ? -42.973 -27.331 -10.901 0.50 84.69  ? 427  GLU   A C   1 
ATOM   1091 O  O   . GLU   A 1 164 ? -43.849 -27.660 -10.082 0.50 86.47  ? 427  GLU   A O   1 
ATOM   1092 C  CB  . GLU   A 1 164 ? -42.972 -29.784 -11.523 0.50 85.64  ? 427  GLU   A CB  1 
ATOM   1093 C  CG  . GLU   A 1 164 ? -42.382 -30.882 -12.386 0.50 87.95  ? 427  GLU   A CG  1 
ATOM   1094 C  CD  . GLU   A 1 164 ? -42.718 -32.287 -11.919 0.50 91.33  ? 427  GLU   A CD  1 
ATOM   1095 O  OE1 . GLU   A 1 164 ? -43.359 -32.416 -10.858 0.50 90.88  ? 427  GLU   A OE1 1 
ATOM   1096 O  OE2 . GLU   A 1 164 ? -42.341 -33.248 -12.616 0.50 92.62  ? 427  GLU   A OE2 1 
ATOM   1097 N  N   . ASP   A 1 165 ? -42.415 -26.118 -10.962 0.50 84.72  ? 428  ASP   A N   1 
ATOM   1098 C  CA  . ASP   A 1 165 ? -42.821 -25.017 -10.047 0.50 84.21  ? 428  ASP   A CA  1 
ATOM   1099 C  C   . ASP   A 1 165 ? -42.576 -23.677 -10.745 0.50 83.12  ? 428  ASP   A C   1 
ATOM   1100 O  O   . ASP   A 1 165 ? -41.416 -23.405 -11.099 0.50 81.19  ? 428  ASP   A O   1 
ATOM   1101 C  CB  . ASP   A 1 165 ? -42.095 -25.110 -8.703  0.50 85.13  ? 428  ASP   A CB  1 
ATOM   1102 C  CG  . ASP   A 1 165 ? -42.474 -24.017 -7.717  0.50 85.40  ? 428  ASP   A CG  1 
ATOM   1103 O  OD1 . ASP   A 1 165 ? -42.656 -22.865 -8.153  0.50 83.86  ? 428  ASP   A OD1 1 
ATOM   1104 O  OD2 . ASP   A 1 165 ? -42.590 -24.330 -6.519  0.50 85.48  ? 428  ASP   A OD2 1 
ATOM   1105 N  N   . SER   A 1 166 ? -43.619 -22.861 -10.893 0.50 82.84  ? 429  SER   A N   1 
ATOM   1106 C  CA  . SER   A 1 166 ? -43.498 -21.575 -11.629 0.50 81.78  ? 429  SER   A CA  1 
ATOM   1107 C  C   . SER   A 1 166 ? -42.561 -20.607 -10.903 0.50 79.61  ? 429  SER   A C   1 
ATOM   1108 O  O   . SER   A 1 166 ? -41.973 -19.747 -11.578 0.50 80.26  ? 429  SER   A O   1 
ATOM   1109 C  CB  . SER   A 1 166 ? -44.857 -20.972 -11.828 0.50 85.93  ? 429  SER   A CB  1 
ATOM   1110 O  OG  . SER   A 1 166 ? -45.733 -21.902 -12.448 0.50 88.78  ? 429  SER   A OG  1 
ATOM   1111 N  N   . GLY   A 1 167 ? -42.446 -20.730 -9.579  1.00 80.96  ? 430  GLY   A N   1 
ATOM   1112 C  CA  . GLY   A 1 167 ? -41.609 -19.790 -8.806  1.00 76.31  ? 430  GLY   A CA  1 
ATOM   1113 C  C   . GLY   A 1 167 ? -40.166 -19.889 -9.243  1.00 75.92  ? 430  GLY   A C   1 
ATOM   1114 O  O   . GLY   A 1 167 ? -39.524 -18.840 -9.401  1.00 68.22  ? 430  GLY   A O   1 
ATOM   1115 N  N   . PHE   A 1 168 ? -39.690 -21.114 -9.448  1.00 74.29  ? 431  PHE   A N   1 
ATOM   1116 C  CA  . PHE   A 1 168 ? -38.314 -21.329 -9.954  1.00 76.90  ? 431  PHE   A CA  1 
ATOM   1117 C  C   . PHE   A 1 168 ? -38.129 -20.507 -11.219 1.00 74.62  ? 431  PHE   A C   1 
ATOM   1118 O  O   . PHE   A 1 168 ? -37.200 -19.691 -11.283 1.00 69.72  ? 431  PHE   A O   1 
ATOM   1119 C  CB  . PHE   A 1 168 ? -38.139 -22.815 -10.265 1.00 78.66  ? 431  PHE   A CB  1 
ATOM   1120 C  CG  . PHE   A 1 168 ? -36.837 -23.224 -10.903 1.00 75.78  ? 431  PHE   A CG  1 
ATOM   1121 C  CD1 . PHE   A 1 168 ? -35.673 -23.302 -10.158 1.00 77.02  ? 431  PHE   A CD1 1 
ATOM   1122 C  CD2 . PHE   A 1 168 ? -36.787 -23.580 -12.240 1.00 79.10  ? 431  PHE   A CD2 1 
ATOM   1123 C  CE1 . PHE   A 1 168 ? -34.482 -23.696 -10.744 1.00 75.20  ? 431  PHE   A CE1 1 
ATOM   1124 C  CE2 . PHE   A 1 168 ? -35.596 -23.975 -12.825 1.00 76.52  ? 431  PHE   A CE2 1 
ATOM   1125 C  CZ  . PHE   A 1 168 ? -34.446 -24.033 -12.075 1.00 78.58  ? 431  PHE   A CZ  1 
ATOM   1126 N  N   . TRP   A 1 169 ? -39.037 -20.677 -12.177 1.00 71.43  ? 432  TRP   A N   1 
ATOM   1127 C  CA  . TRP   A 1 169 ? -38.858 -19.994 -13.481 1.00 64.60  ? 432  TRP   A CA  1 
ATOM   1128 C  C   . TRP   A 1 169 ? -38.906 -18.465 -13.324 1.00 70.52  ? 432  TRP   A C   1 
ATOM   1129 O  O   . TRP   A 1 169 ? -38.309 -17.782 -14.163 1.00 72.32  ? 432  TRP   A O   1 
ATOM   1130 C  CB  . TRP   A 1 169 ? -39.859 -20.563 -14.493 1.00 58.43  ? 432  TRP   A CB  1 
ATOM   1131 C  CG  . TRP   A 1 169 ? -39.660 -22.030 -14.715 1.00 57.88  ? 432  TRP   A CG  1 
ATOM   1132 C  CD1 . TRP   A 1 169 ? -40.449 -23.047 -14.264 1.00 56.19  ? 432  TRP   A CD1 1 
ATOM   1133 C  CD2 . TRP   A 1 169 ? -38.572 -22.653 -15.421 1.00 55.31  ? 432  TRP   A CD2 1 
ATOM   1134 N  NE1 . TRP   A 1 169 ? -39.936 -24.255 -14.652 1.00 59.51  ? 432  TRP   A NE1 1 
ATOM   1135 C  CE2 . TRP   A 1 169 ? -38.785 -24.045 -15.362 1.00 55.11  ? 432  TRP   A CE2 1 
ATOM   1136 C  CE3 . TRP   A 1 169 ? -37.448 -22.172 -16.101 1.00 58.93  ? 432  TRP   A CE3 1 
ATOM   1137 C  CZ2 . TRP   A 1 169 ? -37.916 -24.956 -15.959 1.00 56.37  ? 432  TRP   A CZ2 1 
ATOM   1138 C  CZ3 . TRP   A 1 169 ? -36.590 -23.073 -16.690 1.00 60.28  ? 432  TRP   A CZ3 1 
ATOM   1139 C  CH2 . TRP   A 1 169 ? -36.823 -24.445 -16.618 1.00 53.36  ? 432  TRP   A CH2 1 
ATOM   1140 N  N   . GLU   A 1 170 ? -39.546 -17.943 -12.273 1.00 77.66  ? 433  GLU   A N   1 
ATOM   1141 C  CA  . GLU   A 1 170 ? -39.548 -16.470 -12.050 1.00 75.15  ? 433  GLU   A CA  1 
ATOM   1142 C  C   . GLU   A 1 170 ? -38.165 -16.072 -11.542 1.00 64.84  ? 433  GLU   A C   1 
ATOM   1143 O  O   . GLU   A 1 170 ? -37.707 -14.974 -11.881 1.00 70.09  ? 433  GLU   A O   1 
ATOM   1144 C  CB  . GLU   A 1 170 ? -40.669 -16.042 -11.098 1.00 78.75  ? 433  GLU   A CB  1 
ATOM   1145 C  CG  . GLU   A 1 170 ? -42.016 -16.649 -11.440 1.00 86.91  ? 433  GLU   A CG  1 
ATOM   1146 C  CD  . GLU   A 1 170 ? -43.151 -16.274 -10.501 1.00 96.43  ? 433  GLU   A CD  1 
ATOM   1147 O  OE1 . GLU   A 1 170 ? -43.099 -15.170 -9.923  1.00 96.20  ? 433  GLU   A OE1 1 
ATOM   1148 O  OE2 . GLU   A 1 170 ? -44.080 -17.089 -10.346 1.00 87.71  ? 433  GLU   A OE2 1 
ATOM   1149 N  N   . LEU   A 1 171 ? -37.549 -16.921 -10.728 1.00 67.42  ? 434  LEU   A N   1 
ATOM   1150 C  CA  . LEU   A 1 171 ? -36.142 -16.688 -10.284 1.00 68.47  ? 434  LEU   A CA  1 
ATOM   1151 C  C   . LEU   A 1 171 ? -35.238 -16.732 -11.528 1.00 60.93  ? 434  LEU   A C   1 
ATOM   1152 O  O   . LEU   A 1 171 ? -34.497 -15.748 -11.783 1.00 53.70  ? 434  LEU   A O   1 
ATOM   1153 C  CB  . LEU   A 1 171 ? -35.754 -17.746 -9.243  1.00 66.25  ? 434  LEU   A CB  1 
ATOM   1154 C  CG  . LEU   A 1 171 ? -36.604 -17.789 -7.968  1.00 72.25  ? 434  LEU   A CG  1 
ATOM   1155 C  CD1 . LEU   A 1 171 ? -35.988 -18.746 -6.957  1.00 75.46  ? 434  LEU   A CD1 1 
ATOM   1156 C  CD2 . LEU   A 1 171 ? -36.770 -16.403 -7.349  1.00 70.22  ? 434  LEU   A CD2 1 
ATOM   1157 N  N   . VAL   A 1 172 ? -35.383 -17.796 -12.322 1.00 62.69  ? 435  VAL   A N   1 
ATOM   1158 C  CA  . VAL   A 1 172 ? -34.735 -17.957 -13.659 1.00 61.68  ? 435  VAL   A CA  1 
ATOM   1159 C  C   . VAL   A 1 172 ? -34.959 -16.671 -14.456 1.00 55.32  ? 435  VAL   A C   1 
ATOM   1160 O  O   . VAL   A 1 172 ? -33.967 -16.055 -14.885 1.00 58.40  ? 435  VAL   A O   1 
ATOM   1161 C  CB  . VAL   A 1 172 ? -35.276 -19.201 -14.389 1.00 61.57  ? 435  VAL   A CB  1 
ATOM   1162 C  CG1 . VAL   A 1 172 ? -34.732 -19.286 -15.805 1.00 66.32  ? 435  VAL   A CG1 1 
ATOM   1163 C  CG2 . VAL   A 1 172 ? -34.987 -20.485 -13.617 1.00 58.51  ? 435  VAL   A CG2 1 
ATOM   1164 N  N   . ASP   A 1 173 ? -36.221 -16.235 -14.582 1.00 61.38  ? 436  ASP   A N   1 
ATOM   1165 C  CA  . ASP   A 1 173 ? -36.599 -15.009 -15.336 1.00 62.49  ? 436  ASP   A CA  1 
ATOM   1166 C  C   . ASP   A 1 173 ? -35.865 -13.793 -14.761 1.00 60.38  ? 436  ASP   A C   1 
ATOM   1167 O  O   . ASP   A 1 173 ? -35.349 -12.989 -15.560 1.00 59.16  ? 436  ASP   A O   1 
ATOM   1168 C  CB  . ASP   A 1 173 ? -38.120 -14.800 -15.380 1.00 74.45  ? 436  ASP   A CB  1 
ATOM   1169 C  CG  . ASP   A 1 173 ? -38.815 -15.635 -16.444 1.00 75.73  ? 436  ASP   A CG  1 
ATOM   1170 O  OD1 . ASP   A 1 173 ? -38.317 -15.652 -17.599 1.00 76.02  ? 436  ASP   A OD1 1 
ATOM   1171 O  OD2 . ASP   A 1 173 ? -39.838 -16.281 -16.109 1.00 83.28  ? 436  ASP   A OD2 1 
ATOM   1172 N  N   . LYS   A 1 174 ? -35.769 -13.652 -13.436 1.00 64.37  ? 437  LYS   A N   1 
ATOM   1173 C  CA  . LYS   A 1 174 ? -35.087 -12.461 -12.855 1.00 64.55  ? 437  LYS   A CA  1 
ATOM   1174 C  C   . LYS   A 1 174 ? -33.621 -12.456 -13.305 1.00 56.42  ? 437  LYS   A C   1 
ATOM   1175 O  O   . LYS   A 1 174 ? -33.171 -11.431 -13.844 1.00 62.13  ? 437  LYS   A O   1 
ATOM   1176 C  CB  . LYS   A 1 174 ? -35.200 -12.405 -11.328 1.00 69.69  ? 437  LYS   A CB  1 
ATOM   1177 C  CG  . LYS   A 1 174 ? -34.826 -11.051 -10.739 1.00 74.88  ? 437  LYS   A CG  1 
ATOM   1178 C  CD  . LYS   A 1 174 ? -34.813 -10.987 -9.216  1.00 76.39  ? 437  LYS   A CD  1 
ATOM   1179 C  CE  . LYS   A 1 174 ? -34.308 -9.649  -8.711  1.00 77.42  ? 437  LYS   A CE  1 
ATOM   1180 N  NZ  . LYS   A 1 174 ? -33.842 -9.738  -7.308  1.00 82.98  ? 437  LYS   A NZ  1 
ATOM   1181 N  N   . GLU   A 1 175 ? -32.892 -13.556 -13.104 1.00 60.42  ? 438  GLU   A N   1 
ATOM   1182 C  CA  . GLU   A 1 175 ? -31.462 -13.631 -13.509 1.00 58.51  ? 438  GLU   A CA  1 
ATOM   1183 C  C   . GLU   A 1 175 ? -31.375 -13.449 -15.023 1.00 53.68  ? 438  GLU   A C   1 
ATOM   1184 O  O   . GLU   A 1 175 ? -30.485 -12.699 -15.481 1.00 58.71  ? 438  GLU   A O   1 
ATOM   1185 C  CB  . GLU   A 1 175 ? -30.835 -14.948 -13.074 1.00 60.53  ? 438  GLU   A CB  1 
ATOM   1186 C  CG  . GLU   A 1 175 ? -30.036 -14.797 -11.799 1.00 66.80  ? 438  GLU   A CG  1 
ATOM   1187 C  CD  . GLU   A 1 175 ? -28.662 -14.196 -11.997 1.00 60.65  ? 438  GLU   A CD  1 
ATOM   1188 O  OE1 . GLU   A 1 175 ? -27.744 -14.941 -12.349 1.00 70.28  ? 438  GLU   A OE1 1 
ATOM   1189 O  OE2 . GLU   A 1 175 ? -28.517 -12.987 -11.799 1.00 77.19  ? 438  GLU   A OE2 1 
ATOM   1190 N  N   . ARG   A 1 176 ? -32.301 -14.071 -15.763 1.00 56.67  ? 439  ARG   A N   1 
ATOM   1191 C  CA  . ARG   A 1 176 ? -32.309 -13.973 -17.242 1.00 52.73  ? 439  ARG   A CA  1 
ATOM   1192 C  C   . ARG   A 1 176 ? -32.246 -12.503 -17.633 1.00 56.52  ? 439  ARG   A C   1 
ATOM   1193 O  O   . ARG   A 1 176 ? -31.358 -12.148 -18.437 1.00 56.16  ? 439  ARG   A O   1 
ATOM   1194 C  CB  . ARG   A 1 176 ? -33.540 -14.640 -17.841 1.00 57.59  ? 439  ARG   A CB  1 
ATOM   1195 C  CG  . ARG   A 1 176 ? -33.483 -14.718 -19.359 1.00 56.26  ? 439  ARG   A CG  1 
ATOM   1196 C  CD  . ARG   A 1 176 ? -34.111 -16.000 -19.841 1.00 53.92  ? 439  ARG   A CD  1 
ATOM   1197 N  NE  . ARG   A 1 176 ? -34.180 -15.898 -21.277 1.00 66.82  ? 439  ARG   A NE  1 
ATOM   1198 C  CZ  . ARG   A 1 176 ? -34.932 -16.652 -22.049 1.00 79.40  ? 439  ARG   A CZ  1 
ATOM   1199 N  NH1 . ARG   A 1 176 ? -35.668 -17.616 -21.513 1.00 89.29  ? 439  ARG   A NH1 1 
ATOM   1200 N  NH2 . ARG   A 1 176 ? -34.916 -16.460 -23.359 1.00 74.53  ? 439  ARG   A NH2 1 
ATOM   1201 N  N   . ASN   A 1 177 ? -33.121 -11.675 -17.042 1.00 64.01  ? 440  ASN   A N   1 
ATOM   1202 C  CA  . ASN   A 1 177 ? -33.244 -10.224 -17.369 1.00 61.91  ? 440  ASN   A CA  1 
ATOM   1203 C  C   . ASN   A 1 177 ? -32.004 -9.482  -16.862 1.00 57.84  ? 440  ASN   A C   1 
ATOM   1204 O  O   . ASN   A 1 177 ? -31.528 -8.589  -17.587 1.00 62.78  ? 440  ASN   A O   1 
ATOM   1205 C  CB  . ASN   A 1 177 ? -34.582 -9.644  -16.891 1.00 66.55  ? 440  ASN   A CB  1 
ATOM   1206 C  CG  . ASN   A 1 177 ? -35.730 -10.131 -17.757 1.00 66.95  ? 440  ASN   A CG  1 
ATOM   1207 O  OD1 . ASN   A 1 177 ? -35.880 -9.707  -18.903 1.00 74.72  ? 440  ASN   A OD1 1 
ATOM   1208 N  ND2 . ASN   A 1 177 ? -36.515 -11.062 -17.247 1.00 68.46  ? 440  ASN   A ND2 1 
ATOM   1209 N  N   . LEU   A 1 178 ? -31.445 -9.876  -15.714 1.00 63.37  ? 441  LEU   A N   1 
ATOM   1210 C  CA  . LEU   A 1 178 ? -30.132 -9.359  -15.236 1.00 62.44  ? 441  LEU   A CA  1 
ATOM   1211 C  C   . LEU   A 1 178 ? -29.033 -9.614  -16.282 1.00 61.64  ? 441  LEU   A C   1 
ATOM   1212 O  O   . LEU   A 1 178 ? -28.273 -8.665  -16.586 1.00 65.70  ? 441  LEU   A O   1 
ATOM   1213 C  CB  . LEU   A 1 178 ? -29.793 -10.008 -13.891 1.00 69.27  ? 441  LEU   A CB  1 
ATOM   1214 C  CG  . LEU   A 1 178 ? -30.646 -9.525  -12.717 1.00 76.30  ? 441  LEU   A CG  1 
ATOM   1215 C  CD1 . LEU   A 1 178 ? -30.256 -10.229 -11.420 1.00 79.67  ? 441  LEU   A CD1 1 
ATOM   1216 C  CD2 . LEU   A 1 178 ? -30.544 -8.015  -12.559 1.00 78.44  ? 441  LEU   A CD2 1 
ATOM   1217 N  N   . HIS   A 1 179 ? -28.947 -10.828 -16.832 1.00 59.45  ? 442  HIS   A N   1 
ATOM   1218 C  CA  . HIS   A 1 179 ? -27.962 -11.196 -17.894 1.00 63.86  ? 442  HIS   A CA  1 
ATOM   1219 C  C   . HIS   A 1 179 ? -28.132 -10.316 -19.147 1.00 63.87  ? 442  HIS   A C   1 
ATOM   1220 O  O   . HIS   A 1 179 ? -27.105 -9.805  -19.643 1.00 62.47  ? 442  HIS   A O   1 
ATOM   1221 C  CB  . HIS   A 1 179 ? -28.053 -12.699 -18.217 1.00 62.29  ? 442  HIS   A CB  1 
ATOM   1222 C  CG  . HIS   A 1 179 ? -27.464 -13.588 -17.169 1.00 54.72  ? 442  HIS   A CG  1 
ATOM   1223 N  ND1 . HIS   A 1 179 ? -27.382 -14.955 -17.323 1.00 50.01  ? 442  HIS   A ND1 1 
ATOM   1224 C  CD2 . HIS   A 1 179 ? -26.908 -13.297 -15.974 1.00 54.45  ? 442  HIS   A CD2 1 
ATOM   1225 C  CE1 . HIS   A 1 179 ? -26.837 -15.472 -16.240 1.00 52.86  ? 442  HIS   A CE1 1 
ATOM   1226 N  NE2 . HIS   A 1 179 ? -26.528 -14.465 -15.397 1.00 51.00  ? 442  HIS   A NE2 1 
ATOM   1227 N  N   . LEU   A 1 180 ? -29.368 -10.126 -19.643 1.00 76.97  ? 443  LEU   A N   1 
ATOM   1228 C  CA  . LEU   A 1 180 ? -29.667 -9.256  -20.827 1.00 72.12  ? 443  LEU   A CA  1 
ATOM   1229 C  C   . LEU   A 1 180 ? -29.186 -7.826  -20.537 1.00 67.50  ? 443  LEU   A C   1 
ATOM   1230 O  O   . LEU   A 1 180 ? -28.778 -7.122  -21.478 1.00 72.11  ? 443  LEU   A O   1 
ATOM   1231 C  CB  . LEU   A 1 180 ? -31.167 -9.298  -21.159 1.00 71.83  ? 443  LEU   A CB  1 
ATOM   1232 C  CG  . LEU   A 1 180 ? -31.733 -10.654 -21.600 1.00 67.41  ? 443  LEU   A CG  1 
ATOM   1233 C  CD1 . LEU   A 1 180 ? -33.254 -10.617 -21.670 1.00 68.32  ? 443  LEU   A CD1 1 
ATOM   1234 C  CD2 . LEU   A 1 180 ? -31.175 -11.098 -22.939 1.00 66.24  ? 443  LEU   A CD2 1 
ATOM   1235 N  N   . GLU   A 1 181 ? -29.152 -7.457  -19.256 1.00 73.42  ? 444  GLU   A N   1 
ATOM   1236 C  CA  . GLU   A 1 181 ? -28.699 -6.143  -18.733 1.00 78.77  ? 444  GLU   A CA  1 
ATOM   1237 C  C   . GLU   A 1 181 ? -27.185 -6.160  -18.447 1.00 77.83  ? 444  GLU   A C   1 
ATOM   1238 O  O   . GLU   A 1 181 ? -26.663 -5.115  -18.000 1.00 70.02  ? 444  GLU   A O   1 
ATOM   1239 C  CB  . GLU   A 1 181 ? -29.509 -5.849  -17.467 1.00 86.61  ? 444  GLU   A CB  1 
ATOM   1240 C  CG  . GLU   A 1 181 ? -29.858 -4.392  -17.243 1.00 92.28  ? 444  GLU   A CG  1 
ATOM   1241 C  CD  . GLU   A 1 181 ? -30.471 -4.128  -15.873 1.00 94.49  ? 444  GLU   A CD  1 
ATOM   1242 O  OE1 . GLU   A 1 181 ? -30.327 -2.988  -15.378 1.00 99.16  ? 444  GLU   A OE1 1 
ATOM   1243 O  OE2 . GLU   A 1 181 ? -31.080 -5.067  -15.290 1.00 89.63  ? 444  GLU   A OE2 1 
ATOM   1244 N  N   . GLY   A 1 182 ? -26.497 -7.292  -18.665 1.00 76.19  ? 445  GLY   A N   1 
ATOM   1245 C  CA  . GLY   A 1 182 ? -25.024 -7.397  -18.548 1.00 68.00  ? 445  GLY   A CA  1 
ATOM   1246 C  C   . GLY   A 1 182 ? -24.534 -7.566  -17.111 1.00 63.71  ? 445  GLY   A C   1 
ATOM   1247 O  O   . GLY   A 1 182 ? -23.351 -7.289  -16.871 1.00 68.09  ? 445  GLY   A O   1 
ATOM   1248 N  N   . LYS   A 1 183 ? -25.385 -8.057  -16.205 1.00 59.41  ? 446  LYS   A N   1 
ATOM   1249 C  CA  . LYS   A 1 183 ? -25.130 -8.190  -14.741 1.00 61.88  ? 446  LYS   A CA  1 
ATOM   1250 C  C   . LYS   A 1 183 ? -25.563 -9.582  -14.268 1.00 48.07  ? 446  LYS   A C   1 
ATOM   1251 O  O   . LYS   A 1 183 ? -26.397 -10.191 -14.939 1.00 53.44  ? 446  LYS   A O   1 
ATOM   1252 C  CB  . LYS   A 1 183 ? -25.955 -7.182  -13.924 1.00 71.33  ? 446  LYS   A CB  1 
ATOM   1253 C  CG  . LYS   A 1 183 ? -25.839 -5.713  -14.323 1.00 74.19  ? 446  LYS   A CG  1 
ATOM   1254 C  CD  . LYS   A 1 183 ? -27.046 -4.895  -13.885 1.00 78.42  ? 446  LYS   A CD  1 
ATOM   1255 C  CE  . LYS   A 1 183 ? -27.183 -3.579  -14.620 1.00 81.47  ? 446  LYS   A CE  1 
ATOM   1256 N  NZ  . LYS   A 1 183 ? -26.730 -2.438  -13.793 1.00 86.83  ? 446  LYS   A NZ  1 
ATOM   1257 N  N   . CYS   A 1 184 ? -25.101 -10.011 -13.093 1.00 51.96  ? 447  CYS   A N   1 
ATOM   1258 C  CA  . CYS   A 1 184 ? -25.313 -11.370 -12.521 1.00 50.24  ? 447  CYS   A CA  1 
ATOM   1259 C  C   . CYS   A 1 184 ? -25.503 -11.272 -10.998 1.00 52.32  ? 447  CYS   A C   1 
ATOM   1260 O  O   . CYS   A 1 184 ? -24.758 -10.499 -10.366 1.00 58.08  ? 447  CYS   A O   1 
ATOM   1261 C  CB  . CYS   A 1 184 ? -24.092 -12.233 -12.873 1.00 53.19  ? 447  CYS   A CB  1 
ATOM   1262 S  SG  . CYS   A 1 184 ? -24.274 -13.990 -12.473 1.00 48.82  ? 447  CYS   A SG  1 
ATOM   1263 N  N   . GLU   A 1 185 ? -26.378 -12.090 -10.402 1.00 57.43  ? 448  GLU   A N   1 
ATOM   1264 C  CA  . GLU   A 1 185 ? -26.641 -12.041 -8.937  1.00 62.19  ? 448  GLU   A CA  1 
ATOM   1265 C  C   . GLU   A 1 185 ? -26.518 -13.418 -8.279  1.00 65.38  ? 448  GLU   A C   1 
ATOM   1266 O  O   . GLU   A 1 185 ? -26.113 -13.454 -7.082  1.00 60.19  ? 448  GLU   A O   1 
ATOM   1267 C  CB  . GLU   A 1 185 ? -28.027 -11.452 -8.666  1.00 73.01  ? 448  GLU   A CB  1 
ATOM   1268 C  CG  . GLU   A 1 185 ? -28.255 -11.070 -7.213  1.00 75.41  ? 448  GLU   A CG  1 
ATOM   1269 C  CD  . GLU   A 1 185 ? -29.629 -10.493 -6.917  1.00 81.72  ? 448  GLU   A CD  1 
ATOM   1270 O  OE1 . GLU   A 1 185 ? -29.682 -9.299  -6.541  1.00 80.71  ? 448  GLU   A OE1 1 
ATOM   1271 O  OE2 . GLU   A 1 185 ? -30.644 -11.243 -7.057  1.00 76.62  ? 448  GLU   A OE2 1 
ATOM   1272 N  N   . THR   A 1 186 ? -26.878 -14.504 -8.972  1.00 55.14  ? 449  THR   A N   1 
ATOM   1273 C  CA  . THR   A 1 186 ? -27.031 -15.835 -8.336  1.00 54.78  ? 449  THR   A CA  1 
ATOM   1274 C  C   . THR   A 1 186 ? -26.177 -16.919 -9.014  1.00 53.45  ? 449  THR   A C   1 
ATOM   1275 O  O   . THR   A 1 186 ? -26.206 -18.036 -8.480  1.00 55.54  ? 449  THR   A O   1 
ATOM   1276 C  CB  . THR   A 1 186 ? -28.507 -16.242 -8.313  1.00 64.70  ? 449  THR   A CB  1 
ATOM   1277 O  OG1 . THR   A 1 186 ? -28.945 -16.327 -9.668  1.00 67.09  ? 449  THR   A OG1 1 
ATOM   1278 C  CG2 . THR   A 1 186 ? -29.391 -15.267 -7.567  1.00 65.70  ? 449  THR   A CG2 1 
ATOM   1279 N  N   . CYS   A 1 187 ? -25.437 -16.631 -10.101 1.00 47.36  ? 450  CYS   A N   1 
ATOM   1280 C  CA  . CYS   A 1 187 ? -24.575 -17.629 -10.810 1.00 47.14  ? 450  CYS   A CA  1 
ATOM   1281 C  C   . CYS   A 1 187 ? -23.219 -17.799 -10.074 1.00 47.05  ? 450  CYS   A C   1 
ATOM   1282 O  O   . CYS   A 1 187 ? -22.199 -17.159 -10.465 1.00 44.40  ? 450  CYS   A O   1 
ATOM   1283 C  CB  . CYS   A 1 187 ? -24.470 -17.248 -12.285 1.00 51.42  ? 450  CYS   A CB  1 
ATOM   1284 S  SG  . CYS   A 1 187 ? -26.100 -16.999 -13.069 1.00 47.88  ? 450  CYS   A SG  1 
ATOM   1285 N  N   . VAL   A 1 188 ? -23.209 -18.646 -9.039  0.50 48.75  ? 451  VAL   A N   1 
ATOM   1286 C  CA  . VAL   A 1 188 ? -22.050 -18.879 -8.122  0.50 51.06  ? 451  VAL   A CA  1 
ATOM   1287 C  C   . VAL   A 1 188 ? -21.722 -20.376 -8.086  0.50 50.39  ? 451  VAL   A C   1 
ATOM   1288 O  O   . VAL   A 1 188 ? -22.648 -21.185 -7.915  0.50 47.98  ? 451  VAL   A O   1 
ATOM   1289 C  CB  . VAL   A 1 188 ? -22.347 -18.350 -6.705  0.50 53.80  ? 451  VAL   A CB  1 
ATOM   1290 C  CG1 . VAL   A 1 188 ? -21.377 -18.916 -5.673  0.50 54.29  ? 451  VAL   A CG1 1 
ATOM   1291 C  CG2 . VAL   A 1 188 ? -22.351 -16.830 -6.668  0.50 56.43  ? 451  VAL   A CG2 1 
ATOM   1292 N  N   . TYR   A 1 189 ? -20.438 -20.720 -8.212  1.00 51.44  ? 452  TYR   A N   1 
ATOM   1293 C  CA  . TYR   A 1 189 ? -19.965 -22.130 -8.195  1.00 57.20  ? 452  TYR   A CA  1 
ATOM   1294 C  C   . TYR   A 1 189 ? -19.783 -22.597 -6.746  1.00 60.76  ? 452  TYR   A C   1 
ATOM   1295 O  O   . TYR   A 1 189 ? -19.502 -21.770 -5.863  1.00 62.48  ? 452  TYR   A O   1 
ATOM   1296 C  CB  . TYR   A 1 189 ? -18.694 -22.278 -9.027  1.00 55.35  ? 452  TYR   A CB  1 
ATOM   1297 C  CG  . TYR   A 1 189 ? -18.931 -22.105 -10.504 1.00 57.75  ? 452  TYR   A CG  1 
ATOM   1298 C  CD1 . TYR   A 1 189 ? -19.630 -23.058 -11.231 1.00 60.26  ? 452  TYR   A CD1 1 
ATOM   1299 C  CD2 . TYR   A 1 189 ? -18.460 -20.989 -11.175 1.00 60.70  ? 452  TYR   A CD2 1 
ATOM   1300 C  CE1 . TYR   A 1 189 ? -19.858 -22.896 -12.589 1.00 64.58  ? 452  TYR   A CE1 1 
ATOM   1301 C  CE2 . TYR   A 1 189 ? -18.667 -20.818 -12.536 1.00 60.96  ? 452  TYR   A CE2 1 
ATOM   1302 C  CZ  . TYR   A 1 189 ? -19.374 -21.773 -13.243 1.00 60.79  ? 452  TYR   A CZ  1 
ATOM   1303 O  OH  . TYR   A 1 189 ? -19.566 -21.600 -14.582 1.00 65.88  ? 452  TYR   A OH  1 
ATOM   1304 N  N   . ASN   A 1 190 ? -19.977 -23.901 -6.525  0.50 64.44  ? 453  ASN   A N   1 
ATOM   1305 C  CA  . ASN   A 1 190 ? -19.708 -24.622 -5.251  0.50 66.66  ? 453  ASN   A CA  1 
ATOM   1306 C  C   . ASN   A 1 190 ? -18.742 -25.777 -5.543  0.50 66.61  ? 453  ASN   A C   1 
ATOM   1307 O  O   . ASN   A 1 190 ? -19.125 -26.677 -6.310  0.50 62.95  ? 453  ASN   A O   1 
ATOM   1308 C  CB  . ASN   A 1 190 ? -20.997 -25.141 -4.611  0.50 69.13  ? 453  ASN   A CB  1 
ATOM   1309 C  CG  . ASN   A 1 190 ? -22.080 -24.087 -4.516  0.50 70.50  ? 453  ASN   A CG  1 
ATOM   1310 O  OD1 . ASN   A 1 190 ? -22.293 -23.316 -5.449  0.50 76.91  ? 453  ASN   A OD1 1 
ATOM   1311 N  ND2 . ASN   A 1 190 ? -22.786 -24.059 -3.398  0.50 72.13  ? 453  ASN   A ND2 1 
ATOM   1312 N  N   . MET   A 1 191 ? -17.539 -25.747 -4.958  1.00 71.34  ? 454  MET   A N   1 
ATOM   1313 C  CA  . MET   A 1 191 ? -16.456 -26.730 -5.260  1.00 80.23  ? 454  MET   A CA  1 
ATOM   1314 C  C   . MET   A 1 191 ? -16.631 -28.005 -4.424  1.00 91.00  ? 454  MET   A C   1 
ATOM   1315 O  O   . MET   A 1 191 ? -17.205 -27.904 -3.323  1.00 96.83  ? 454  MET   A O   1 
ATOM   1316 C  CB  . MET   A 1 191 ? -15.089 -26.110 -4.972  1.00 88.01  ? 454  MET   A CB  1 
ATOM   1317 C  CG  . MET   A 1 191 ? -13.967 -26.737 -5.761  1.00 99.06  ? 454  MET   A CG  1 
ATOM   1318 S  SD  . MET   A 1 191 ? -12.525 -25.648 -5.850  1.00 111.89 ? 454  MET   A SD  1 
ATOM   1319 C  CE  . MET   A 1 191 ? -12.817 -24.854 -7.428  1.00 111.42 ? 454  MET   A CE  1 
ATOM   1320 N  N   . MET   A 1 192 ? -16.172 -29.154 -4.951  1.00 102.55 ? 455  MET   A N   1 
ATOM   1321 C  CA  . MET   A 1 192 ? -16.264 -30.508 -4.320  1.00 101.79 ? 455  MET   A CA  1 
ATOM   1322 C  C   . MET   A 1 192 ? -15.513 -31.555 -5.160  1.00 102.31 ? 455  MET   A C   1 
ATOM   1323 O  O   . MET   A 1 192 ? -15.397 -31.347 -6.389  1.00 100.31 ? 455  MET   A O   1 
ATOM   1324 C  CB  . MET   A 1 192 ? -17.725 -30.946 -4.162  1.00 99.32  ? 455  MET   A CB  1 
ATOM   1325 C  CG  . MET   A 1 192 ? -18.246 -30.812 -2.743  1.00 96.28  ? 455  MET   A CG  1 
ATOM   1326 S  SD  . MET   A 1 192 ? -19.993 -30.360 -2.671  1.00 93.20  ? 455  MET   A SD  1 
ATOM   1327 C  CE  . MET   A 1 192 ? -20.762 -31.975 -2.527  1.00 93.42  ? 455  MET   A CE  1 
ATOM   1328 N  N   . ALA   A 1 210 ? -11.869 -32.071 -9.778  0.50 86.08  ? 473  ALA   A N   1 
ATOM   1329 C  CA  . ALA   A 1 210 ? -12.715 -31.025 -9.156  0.50 83.24  ? 473  ALA   A CA  1 
ATOM   1330 C  C   . ALA   A 1 210 ? -14.012 -30.874 -9.957  0.50 81.33  ? 473  ALA   A C   1 
ATOM   1331 O  O   . ALA   A 1 210 ? -13.933 -30.777 -11.197 0.50 81.98  ? 473  ALA   A O   1 
ATOM   1332 C  CB  . ALA   A 1 210 ? -11.954 -29.722 -9.087  0.50 82.61  ? 473  ALA   A CB  1 
ATOM   1333 N  N   . ILE   A 1 211 ? -15.159 -30.872 -9.269  0.50 78.08  ? 474  ILE   A N   1 
ATOM   1334 C  CA  . ILE   A 1 211 ? -16.503 -30.617 -9.869  0.50 73.71  ? 474  ILE   A CA  1 
ATOM   1335 C  C   . ILE   A 1 211 ? -17.059 -29.319 -9.274  0.50 70.67  ? 474  ILE   A C   1 
ATOM   1336 O  O   . ILE   A 1 211 ? -16.962 -29.135 -8.044  0.50 68.79  ? 474  ILE   A O   1 
ATOM   1337 C  CB  . ILE   A 1 211 ? -17.462 -31.805 -9.649  0.50 73.79  ? 474  ILE   A CB  1 
ATOM   1338 C  CG1 . ILE   A 1 211 ? -16.829 -33.137 -10.061 0.50 76.10  ? 474  ILE   A CG1 1 
ATOM   1339 C  CG2 . ILE   A 1 211 ? -18.785 -31.566 -10.361 0.50 72.10  ? 474  ILE   A CG2 1 
ATOM   1340 C  CD1 . ILE   A 1 211 ? -15.893 -33.722 -9.026  0.50 75.74  ? 474  ILE   A CD1 1 
ATOM   1341 N  N   . TRP   A 1 212 ? -17.609 -28.456 -10.130 0.50 68.86  ? 475  TRP   A N   1 
ATOM   1342 C  CA  . TRP   A 1 212 ? -18.175 -27.133 -9.765  0.50 68.29  ? 475  TRP   A CA  1 
ATOM   1343 C  C   . TRP   A 1 212 ? -19.695 -27.172 -9.937  0.50 65.90  ? 475  TRP   A C   1 
ATOM   1344 O  O   . TRP   A 1 212 ? -20.162 -26.915 -11.061 0.50 67.73  ? 475  TRP   A O   1 
ATOM   1345 C  CB  . TRP   A 1 212 ? -17.543 -26.030 -10.624 0.50 69.26  ? 475  TRP   A CB  1 
ATOM   1346 C  CG  . TRP   A 1 212 ? -16.049 -25.972 -10.545 0.50 69.49  ? 475  TRP   A CG  1 
ATOM   1347 C  CD1 . TRP   A 1 212 ? -15.192 -27.019 -10.372 0.50 71.34  ? 475  TRP   A CD1 1 
ATOM   1348 C  CD2 . TRP   A 1 212 ? -15.227 -24.798 -10.664 0.50 68.44  ? 475  TRP   A CD2 1 
ATOM   1349 N  NE1 . TRP   A 1 212 ? -13.896 -26.577 -10.364 0.50 71.12  ? 475  TRP   A NE1 1 
ATOM   1350 C  CE2 . TRP   A 1 212 ? -13.886 -25.220 -10.547 0.50 68.29  ? 475  TRP   A CE2 1 
ATOM   1351 C  CE3 . TRP   A 1 212 ? -15.490 -23.438 -10.856 0.50 67.18  ? 475  TRP   A CE3 1 
ATOM   1352 C  CZ2 . TRP   A 1 212 ? -12.818 -24.328 -10.614 0.50 68.39  ? 475  TRP   A CZ2 1 
ATOM   1353 C  CZ3 . TRP   A 1 212 ? -14.433 -22.557 -10.927 0.50 67.26  ? 475  TRP   A CZ3 1 
ATOM   1354 C  CH2 . TRP   A 1 212 ? -13.116 -22.999 -10.809 0.50 67.86  ? 475  TRP   A CH2 1 
ATOM   1355 N  N   . TYR   A 1 213 ? -20.424 -27.494 -8.866  0.50 65.43  ? 476  TYR   A N   1 
ATOM   1356 C  CA  . TYR   A 1 213 ? -21.910 -27.498 -8.816  0.50 63.40  ? 476  TYR   A CA  1 
ATOM   1357 C  C   . TYR   A 1 213 ? -22.425 -26.053 -8.851  0.50 60.52  ? 476  TYR   A C   1 
ATOM   1358 O  O   . TYR   A 1 213 ? -21.745 -25.143 -8.341  0.50 55.88  ? 476  TYR   A O   1 
ATOM   1359 C  CB  . TYR   A 1 213 ? -22.404 -28.239 -7.570  0.50 67.32  ? 476  TYR   A CB  1 
ATOM   1360 C  CG  . TYR   A 1 213 ? -22.057 -29.706 -7.531  0.50 71.36  ? 476  TYR   A CG  1 
ATOM   1361 C  CD1 . TYR   A 1 213 ? -22.942 -30.663 -8.001  0.50 74.22  ? 476  TYR   A CD1 1 
ATOM   1362 C  CD2 . TYR   A 1 213 ? -20.844 -30.143 -7.024  0.50 74.89  ? 476  TYR   A CD2 1 
ATOM   1363 C  CE1 . TYR   A 1 213 ? -22.630 -32.012 -7.972  0.50 75.76  ? 476  TYR   A CE1 1 
ATOM   1364 C  CE2 . TYR   A 1 213 ? -20.518 -31.490 -6.983  0.50 75.31  ? 476  TYR   A CE2 1 
ATOM   1365 C  CZ  . TYR   A 1 213 ? -21.415 -32.429 -7.460  0.50 75.86  ? 476  TYR   A CZ  1 
ATOM   1366 O  OH  . TYR   A 1 213 ? -21.105 -33.759 -7.426  0.50 76.61  ? 476  TYR   A OH  1 
ATOM   1367 N  N   . MET   A 1 214 ? -23.597 -25.858 -9.458  0.50 59.38  ? 477  MET   A N   1 
ATOM   1368 C  CA  . MET   A 1 214 ? -24.341 -24.571 -9.498  0.50 58.42  ? 477  MET   A CA  1 
ATOM   1369 C  C   . MET   A 1 214 ? -25.782 -24.842 -9.070  0.50 55.72  ? 477  MET   A C   1 
ATOM   1370 O  O   . MET   A 1 214 ? -26.166 -26.025 -9.041  0.50 54.79  ? 477  MET   A O   1 
ATOM   1371 C  CB  . MET   A 1 214 ? -24.358 -23.984 -10.910 0.50 60.51  ? 477  MET   A CB  1 
ATOM   1372 C  CG  . MET   A 1 214 ? -23.312 -22.924 -11.158 0.50 62.61  ? 477  MET   A CG  1 
ATOM   1373 S  SD  . MET   A 1 214 ? -23.331 -22.389 -12.888 0.50 64.55  ? 477  MET   A SD  1 
ATOM   1374 C  CE  . MET   A 1 214 ? -22.606 -20.758 -12.723 0.50 63.64  ? 477  MET   A CE  1 
ATOM   1375 N  N   . TRP   A 1 215 ? -26.555 -23.797 -8.768  0.50 55.85  ? 478  TRP   A N   1 
ATOM   1376 C  CA  . TRP   A 1 215 ? -28.022 -23.934 -8.572  0.50 56.48  ? 478  TRP   A CA  1 
ATOM   1377 C  C   . TRP   A 1 215 ? -28.660 -24.176 -9.947  0.50 54.79  ? 478  TRP   A C   1 
ATOM   1378 O  O   . TRP   A 1 215 ? -28.117 -23.670 -10.948 0.50 50.20  ? 478  TRP   A O   1 
ATOM   1379 C  CB  . TRP   A 1 215 ? -28.609 -22.745 -7.793  0.50 56.65  ? 478  TRP   A CB  1 
ATOM   1380 C  CG  . TRP   A 1 215 ? -29.043 -21.547 -8.583  0.50 57.53  ? 478  TRP   A CG  1 
ATOM   1381 C  CD1 . TRP   A 1 215 ? -28.253 -20.558 -9.096  0.50 60.38  ? 478  TRP   A CD1 1 
ATOM   1382 C  CD2 . TRP   A 1 215 ? -30.399 -21.159 -8.871  0.50 58.69  ? 478  TRP   A CD2 1 
ATOM   1383 N  NE1 . TRP   A 1 215 ? -29.019 -19.606 -9.718  0.50 60.64  ? 478  TRP   A NE1 1 
ATOM   1384 C  CE2 . TRP   A 1 215 ? -30.340 -19.948 -9.596  0.50 60.20  ? 478  TRP   A CE2 1 
ATOM   1385 C  CE3 . TRP   A 1 215 ? -31.650 -21.727 -8.607  0.50 56.77  ? 478  TRP   A CE3 1 
ATOM   1386 C  CZ2 . TRP   A 1 215 ? -31.485 -19.298 -10.055 0.50 60.18  ? 478  TRP   A CZ2 1 
ATOM   1387 C  CZ3 . TRP   A 1 215 ? -32.780 -21.088 -9.068  0.50 58.37  ? 478  TRP   A CZ3 1 
ATOM   1388 C  CH2 . TRP   A 1 215 ? -32.697 -19.891 -9.781  0.50 58.31  ? 478  TRP   A CH2 1 
ATOM   1389 N  N   . LEU   A 1 216 ? -29.703 -25.006 -9.997  0.50 54.06  ? 479  LEU   A N   1 
ATOM   1390 C  CA  . LEU   A 1 216 ? -30.332 -25.492 -11.251 0.50 55.11  ? 479  LEU   A CA  1 
ATOM   1391 C  C   . LEU   A 1 216 ? -30.523 -24.316 -12.220 0.50 56.30  ? 479  LEU   A C   1 
ATOM   1392 O  O   . LEU   A 1 216 ? -30.176 -24.471 -13.409 0.50 53.29  ? 479  LEU   A O   1 
ATOM   1393 C  CB  . LEU   A 1 216 ? -31.664 -26.160 -10.903 0.50 56.12  ? 479  LEU   A CB  1 
ATOM   1394 C  CG  . LEU   A 1 216 ? -32.188 -27.139 -11.950 0.50 56.71  ? 479  LEU   A CG  1 
ATOM   1395 C  CD1 . LEU   A 1 216 ? -31.166 -28.232 -12.222 0.50 55.98  ? 479  LEU   A CD1 1 
ATOM   1396 C  CD2 . LEU   A 1 216 ? -33.516 -27.740 -11.513 0.50 58.09  ? 479  LEU   A CD2 1 
ATOM   1397 N  N   . GLY   A 1 217 ? -31.025 -23.185 -11.712 0.50 55.14  ? 480  GLY   A N   1 
ATOM   1398 C  CA  . GLY   A 1 217 ? -31.278 -21.947 -12.475 0.50 54.75  ? 480  GLY   A CA  1 
ATOM   1399 C  C   . GLY   A 1 217 ? -30.094 -21.542 -13.338 0.50 53.98  ? 480  GLY   A C   1 
ATOM   1400 O  O   . GLY   A 1 217 ? -30.254 -21.505 -14.576 0.50 49.64  ? 480  GLY   A O   1 
ATOM   1401 N  N   . ALA   A 1 218 ? -28.953 -21.225 -12.714 0.50 51.75  ? 481  ALA   A N   1 
ATOM   1402 C  CA  . ALA   A 1 218 ? -27.695 -20.834 -13.398 0.50 49.03  ? 481  ALA   A CA  1 
ATOM   1403 C  C   . ALA   A 1 218 ? -27.350 -21.884 -14.460 0.50 47.19  ? 481  ALA   A C   1 
ATOM   1404 O  O   . ALA   A 1 218 ? -26.883 -21.492 -15.546 0.50 46.48  ? 481  ALA   A O   1 
ATOM   1405 C  CB  . ALA   A 1 218 ? -26.584 -20.685 -12.391 0.50 47.44  ? 481  ALA   A CB  1 
ATOM   1406 N  N   . ARG   A 1 219 ? -27.590 -23.159 -14.140 0.50 44.96  ? 482  ARG   A N   1 
ATOM   1407 C  CA  . ARG   A 1 219 ? -27.332 -24.337 -15.014 0.50 47.50  ? 482  ARG   A CA  1 
ATOM   1408 C  C   . ARG   A 1 219 ? -28.280 -24.283 -16.216 0.50 47.05  ? 482  ARG   A C   1 
ATOM   1409 O  O   . ARG   A 1 219 ? -27.827 -24.570 -17.350 0.50 40.51  ? 482  ARG   A O   1 
ATOM   1410 C  CB  . ARG   A 1 219 ? -27.549 -25.636 -14.233 0.50 47.11  ? 482  ARG   A CB  1 
ATOM   1411 C  CG  . ARG   A 1 219 ? -26.674 -26.796 -14.684 0.50 51.96  ? 482  ARG   A CG  1 
ATOM   1412 C  CD  . ARG   A 1 219 ? -25.340 -26.828 -13.952 0.50 54.40  ? 482  ARG   A CD  1 
ATOM   1413 N  NE  . ARG   A 1 219 ? -24.300 -26.040 -14.606 0.50 54.21  ? 482  ARG   A NE  1 
ATOM   1414 C  CZ  . ARG   A 1 219 ? -23.104 -25.794 -14.083 0.50 53.63  ? 482  ARG   A CZ  1 
ATOM   1415 N  NH1 . ARG   A 1 219 ? -22.224 -25.071 -14.756 0.50 54.79  ? 482  ARG   A NH1 1 
ATOM   1416 N  NH2 . ARG   A 1 219 ? -22.792 -26.272 -12.890 0.50 52.34  ? 482  ARG   A NH2 1 
ATOM   1417 N  N   . PHE   A 1 220 ? -29.546 -23.928 -15.966 1.00 48.27  ? 483  PHE   A N   1 
ATOM   1418 C  CA  . PHE   A 1 220 ? -30.559 -23.723 -17.023 1.00 46.16  ? 483  PHE   A CA  1 
ATOM   1419 C  C   . PHE   A 1 220 ? -30.083 -22.660 -18.000 1.00 42.95  ? 483  PHE   A C   1 
ATOM   1420 O  O   . PHE   A 1 220 ? -30.089 -22.909 -19.225 1.00 46.86  ? 483  PHE   A O   1 
ATOM   1421 C  CB  . PHE   A 1 220 ? -31.932 -23.287 -16.511 1.00 48.40  ? 483  PHE   A CB  1 
ATOM   1422 C  CG  . PHE   A 1 220 ? -32.778 -22.882 -17.686 1.00 40.61  ? 483  PHE   A CG  1 
ATOM   1423 C  CD1 . PHE   A 1 220 ? -33.236 -23.844 -18.560 1.00 44.21  ? 483  PHE   A CD1 1 
ATOM   1424 C  CD2 . PHE   A 1 220 ? -32.969 -21.557 -17.999 1.00 38.17  ? 483  PHE   A CD2 1 
ATOM   1425 C  CE1 . PHE   A 1 220 ? -33.960 -23.490 -19.686 1.00 46.31  ? 483  PHE   A CE1 1 
ATOM   1426 C  CE2 . PHE   A 1 220 ? -33.691 -21.199 -19.127 1.00 42.51  ? 483  PHE   A CE2 1 
ATOM   1427 C  CZ  . PHE   A 1 220 ? -34.180 -22.170 -19.966 1.00 39.47  ? 483  PHE   A CZ  1 
ATOM   1428 N  N   . LEU   A 1 221 ? -29.693 -21.495 -17.474 0.50 43.95  ? 484  LEU   A N   1 
ATOM   1429 C  CA  . LEU   A 1 221 ? -29.234 -20.334 -18.279 0.50 45.62  ? 484  LEU   A CA  1 
ATOM   1430 C  C   . LEU   A 1 221 ? -28.003 -20.741 -19.100 0.50 45.73  ? 484  LEU   A C   1 
ATOM   1431 O  O   . LEU   A 1 221 ? -27.934 -20.364 -20.293 0.50 41.21  ? 484  LEU   A O   1 
ATOM   1432 C  CB  . LEU   A 1 221 ? -28.935 -19.151 -17.353 0.50 47.19  ? 484  LEU   A CB  1 
ATOM   1433 C  CG  . LEU   A 1 221 ? -30.166 -18.423 -16.811 0.50 49.66  ? 484  LEU   A CG  1 
ATOM   1434 C  CD1 . LEU   A 1 221 ? -29.764 -17.198 -16.006 0.50 51.77  ? 484  LEU   A CD1 1 
ATOM   1435 C  CD2 . LEU   A 1 221 ? -31.108 -18.024 -17.938 0.50 50.51  ? 484  LEU   A CD2 1 
ATOM   1436 N  N   . GLU   A 1 222 ? -27.074 -21.489 -18.491 0.50 42.45  ? 485  GLU   A N   1 
ATOM   1437 C  CA  . GLU   A 1 222 ? -25.912 -22.077 -19.209 0.50 41.27  ? 485  GLU   A CA  1 
ATOM   1438 C  C   . GLU   A 1 222 ? -26.438 -22.944 -20.363 0.50 39.16  ? 485  GLU   A C   1 
ATOM   1439 O  O   . GLU   A 1 222 ? -25.973 -22.749 -21.499 0.50 37.85  ? 485  GLU   A O   1 
ATOM   1440 C  CB  . GLU   A 1 222 ? -25.018 -22.875 -18.255 0.50 40.95  ? 485  GLU   A CB  1 
ATOM   1441 C  CG  . GLU   A 1 222 ? -23.866 -23.560 -18.964 0.50 40.65  ? 485  GLU   A CG  1 
ATOM   1442 C  CD  . GLU   A 1 222 ? -23.027 -24.483 -18.100 0.50 39.47  ? 485  GLU   A CD  1 
ATOM   1443 O  OE1 . GLU   A 1 222 ? -21.874 -24.117 -17.809 0.50 40.15  ? 485  GLU   A OE1 1 
ATOM   1444 O  OE2 . GLU   A 1 222 ? -23.521 -25.569 -17.735 0.50 38.10  ? 485  GLU   A OE2 1 
ATOM   1445 N  N   . PHE   A 1 223 ? -27.394 -23.841 -20.087 1.00 38.66  ? 486  PHE   A N   1 
ATOM   1446 C  CA  . PHE   A 1 223 ? -27.945 -24.804 -21.088 1.00 39.96  ? 486  PHE   A CA  1 
ATOM   1447 C  C   . PHE   A 1 223 ? -28.623 -24.056 -22.240 1.00 43.38  ? 486  PHE   A C   1 
ATOM   1448 O  O   . PHE   A 1 223 ? -28.386 -24.379 -23.424 1.00 40.03  ? 486  PHE   A O   1 
ATOM   1449 C  CB  . PHE   A 1 223 ? -28.873 -25.804 -20.411 1.00 44.61  ? 486  PHE   A CB  1 
ATOM   1450 C  CG  . PHE   A 1 223 ? -29.562 -26.772 -21.338 1.00 42.56  ? 486  PHE   A CG  1 
ATOM   1451 C  CD1 . PHE   A 1 223 ? -28.872 -27.834 -21.892 1.00 43.06  ? 486  PHE   A CD1 1 
ATOM   1452 C  CD2 . PHE   A 1 223 ? -30.899 -26.610 -21.660 1.00 43.39  ? 486  PHE   A CD2 1 
ATOM   1453 C  CE1 . PHE   A 1 223 ? -29.502 -28.715 -22.760 1.00 46.96  ? 486  PHE   A CE1 1 
ATOM   1454 C  CE2 . PHE   A 1 223 ? -31.536 -27.507 -22.499 1.00 45.64  ? 486  PHE   A CE2 1 
ATOM   1455 C  CZ  . PHE   A 1 223 ? -30.841 -28.565 -23.043 1.00 48.55  ? 486  PHE   A CZ  1 
ATOM   1456 N  N   . GLU   A 1 224 ? -29.417 -23.045 -21.900 0.50 42.22  ? 487  GLU   A N   1 
ATOM   1457 C  CA  . GLU   A 1 224 ? -30.184 -22.233 -22.872 0.50 41.75  ? 487  GLU   A CA  1 
ATOM   1458 C  C   . GLU   A 1 224 ? -29.223 -21.591 -23.883 0.50 42.29  ? 487  GLU   A C   1 
ATOM   1459 O  O   . GLU   A 1 224 ? -29.549 -21.593 -25.098 0.50 39.90  ? 487  GLU   A O   1 
ATOM   1460 C  CB  . GLU   A 1 224 ? -31.003 -21.198 -22.106 0.50 42.65  ? 487  GLU   A CB  1 
ATOM   1461 C  CG  . GLU   A 1 224 ? -31.871 -20.336 -22.994 0.50 43.39  ? 487  GLU   A CG  1 
ATOM   1462 C  CD  . GLU   A 1 224 ? -32.902 -19.540 -22.218 0.50 43.39  ? 487  GLU   A CD  1 
ATOM   1463 O  OE1 . GLU   A 1 224 ? -34.109 -19.759 -22.457 0.50 40.78  ? 487  GLU   A OE1 1 
ATOM   1464 O  OE2 . GLU   A 1 224 ? -32.490 -18.707 -21.384 0.50 42.76  ? 487  GLU   A OE2 1 
ATOM   1465 N  N   . ALA   A 1 225 ? -28.080 -21.080 -23.413 1.00 38.37  ? 488  ALA   A N   1 
ATOM   1466 C  CA  . ALA   A 1 225 ? -27.141 -20.319 -24.255 1.00 36.60  ? 488  ALA   A CA  1 
ATOM   1467 C  C   . ALA   A 1 225 ? -26.178 -21.232 -25.011 1.00 35.93  ? 488  ALA   A C   1 
ATOM   1468 O  O   . ALA   A 1 225 ? -25.811 -20.817 -26.144 1.00 36.76  ? 488  ALA   A O   1 
ATOM   1469 C  CB  . ALA   A 1 225 ? -26.381 -19.319 -23.437 1.00 39.28  ? 488  ALA   A CB  1 
ATOM   1470 N  N   . LEU   A 1 226 ? -25.723 -22.347 -24.424 1.00 35.30  ? 489  LEU   A N   1 
ATOM   1471 C  CA  . LEU   A 1 226 ? -24.531 -23.091 -24.961 1.00 33.47  ? 489  LEU   A CA  1 
ATOM   1472 C  C   . LEU   A 1 226 ? -24.826 -24.580 -25.112 1.00 33.06  ? 489  LEU   A C   1 
ATOM   1473 O  O   . LEU   A 1 226 ? -23.935 -25.324 -25.645 1.00 35.01  ? 489  LEU   A O   1 
ATOM   1474 C  CB  . LEU   A 1 226 ? -23.330 -22.861 -24.030 1.00 31.42  ? 489  LEU   A CB  1 
ATOM   1475 C  CG  . LEU   A 1 226 ? -22.796 -21.430 -24.005 1.00 35.45  ? 489  LEU   A CG  1 
ATOM   1476 C  CD1 . LEU   A 1 226 ? -21.533 -21.315 -23.169 1.00 42.51  ? 489  LEU   A CD1 1 
ATOM   1477 C  CD2 . LEU   A 1 226 ? -22.514 -20.913 -25.406 1.00 38.07  ? 489  LEU   A CD2 1 
ATOM   1478 N  N   . GLY   A 1 227 ? -26.030 -25.030 -24.740 1.00 30.18  ? 490  GLY   A N   1 
ATOM   1479 C  CA  . GLY   A 1 227 ? -26.436 -26.445 -24.851 1.00 32.21  ? 490  GLY   A CA  1 
ATOM   1480 C  C   . GLY   A 1 227 ? -26.450 -26.951 -26.274 1.00 30.25  ? 490  GLY   A C   1 
ATOM   1481 O  O   . GLY   A 1 227 ? -26.234 -28.173 -26.496 1.00 29.13  ? 490  GLY   A O   1 
ATOM   1482 N  N   . PHE   A 1 228 ? -26.671 -26.055 -27.228 1.00 30.91  ? 491  PHE   A N   1 
ATOM   1483 C  CA  . PHE   A 1 228 ? -26.651 -26.379 -28.682 1.00 30.67  ? 491  PHE   A CA  1 
ATOM   1484 C  C   . PHE   A 1 228 ? -25.364 -27.138 -29.065 1.00 29.81  ? 491  PHE   A C   1 
ATOM   1485 O  O   . PHE   A 1 228 ? -25.444 -27.987 -29.960 1.00 27.46  ? 491  PHE   A O   1 
ATOM   1486 C  CB  . PHE   A 1 228 ? -26.852 -25.142 -29.559 1.00 30.60  ? 491  PHE   A CB  1 
ATOM   1487 C  CG  . PHE   A 1 228 ? -25.707 -24.175 -29.691 1.00 30.13  ? 491  PHE   A CG  1 
ATOM   1488 C  CD1 . PHE   A 1 228 ? -25.558 -23.136 -28.792 1.00 33.46  ? 491  PHE   A CD1 1 
ATOM   1489 C  CD2 . PHE   A 1 228 ? -24.766 -24.323 -30.695 1.00 32.09  ? 491  PHE   A CD2 1 
ATOM   1490 C  CE1 . PHE   A 1 228 ? -24.478 -22.273 -28.869 1.00 31.36  ? 491  PHE   A CE1 1 
ATOM   1491 C  CE2 . PHE   A 1 228 ? -23.686 -23.453 -30.779 1.00 31.28  ? 491  PHE   A CE2 1 
ATOM   1492 C  CZ  . PHE   A 1 228 ? -23.542 -22.434 -29.861 1.00 32.84  ? 491  PHE   A CZ  1 
ATOM   1493 N  N   . LEU   A 1 229 ? -24.217 -26.817 -28.461 1.00 29.83  ? 492  LEU   A N   1 
ATOM   1494 C  CA  . LEU   A 1 229 ? -22.927 -27.476 -28.830 1.00 30.71  ? 492  LEU   A CA  1 
ATOM   1495 C  C   . LEU   A 1 229 ? -23.048 -28.988 -28.656 1.00 28.93  ? 492  LEU   A C   1 
ATOM   1496 O  O   . LEU   A 1 229 ? -22.702 -29.727 -29.583 1.00 30.95  ? 492  LEU   A O   1 
ATOM   1497 C  CB  . LEU   A 1 229 ? -21.797 -26.886 -27.982 1.00 32.24  ? 492  LEU   A CB  1 
ATOM   1498 C  CG  . LEU   A 1 229 ? -21.395 -25.463 -28.338 1.00 32.10  ? 492  LEU   A CG  1 
ATOM   1499 C  CD1 . LEU   A 1 229 ? -20.417 -24.955 -27.319 1.00 36.39  ? 492  LEU   A CD1 1 
ATOM   1500 C  CD2 . LEU   A 1 229 ? -20.797 -25.386 -29.737 1.00 32.72  ? 492  LEU   A CD2 1 
ATOM   1501 N  N   . ASN   A 1 230 ? -23.688 -29.430 -27.578 1.00 31.12  ? 493  ASN   A N   1 
ATOM   1502 C  CA  . ASN   A 1 230 ? -23.922 -30.871 -27.331 1.00 28.07  ? 493  ASN   A CA  1 
ATOM   1503 C  C   . ASN   A 1 230 ? -25.229 -31.365 -27.977 1.00 29.45  ? 493  ASN   A C   1 
ATOM   1504 O  O   . ASN   A 1 230 ? -25.206 -32.411 -28.648 1.00 27.19  ? 493  ASN   A O   1 
ATOM   1505 C  CB  . ASN   A 1 230 ? -24.000 -31.142 -25.832 1.00 31.48  ? 493  ASN   A CB  1 
ATOM   1506 C  CG  . ASN   A 1 230 ? -24.010 -32.624 -25.544 1.00 37.04  ? 493  ASN   A CG  1 
ATOM   1507 O  OD1 . ASN   A 1 230 ? -25.017 -33.193 -25.123 1.00 40.23  ? 493  ASN   A OD1 1 
ATOM   1508 N  ND2 . ASN   A 1 230 ? -22.900 -33.261 -25.840 1.00 36.41  ? 493  ASN   A ND2 1 
ATOM   1509 N  N   . GLU   A 1 231 ? -26.334 -30.643 -27.803 1.00 30.22  ? 494  GLU   A N   1 
ATOM   1510 C  CA  . GLU   A 1 231 ? -27.673 -31.102 -28.264 1.00 32.24  ? 494  GLU   A CA  1 
ATOM   1511 C  C   . GLU   A 1 231 ? -27.647 -31.291 -29.783 1.00 28.66  ? 494  GLU   A C   1 
ATOM   1512 O  O   . GLU   A 1 231 ? -28.278 -32.239 -30.251 1.00 29.16  ? 494  GLU   A O   1 
ATOM   1513 C  CB  . GLU   A 1 231 ? -28.763 -30.085 -27.876 1.00 35.26  ? 494  GLU   A CB  1 
ATOM   1514 C  CG  . GLU   A 1 231 ? -29.098 -30.049 -26.395 1.00 39.48  ? 494  GLU   A CG  1 
ATOM   1515 C  CD  . GLU   A 1 231 ? -29.620 -31.367 -25.835 1.00 46.56  ? 494  GLU   A CD  1 
ATOM   1516 O  OE1 . GLU   A 1 231 ? -30.501 -31.974 -26.444 1.00 49.50  ? 494  GLU   A OE1 1 
ATOM   1517 O  OE2 . GLU   A 1 231 ? -29.099 -31.799 -24.813 1.00 52.28  ? 494  GLU   A OE2 1 
ATOM   1518 N  N   . ASP   A 1 232 ? -26.908 -30.452 -30.524 1.00 28.54  ? 495  ASP   A N   1 
ATOM   1519 C  CA  . ASP   A 1 232 ? -26.857 -30.498 -32.008 1.00 27.27  ? 495  ASP   A CA  1 
ATOM   1520 C  C   . ASP   A 1 232 ? -25.492 -30.986 -32.513 1.00 32.61  ? 495  ASP   A C   1 
ATOM   1521 O  O   . ASP   A 1 232 ? -25.210 -30.864 -33.741 1.00 30.78  ? 495  ASP   A O   1 
ATOM   1522 C  CB  . ASP   A 1 232 ? -27.209 -29.130 -32.600 1.00 31.05  ? 495  ASP   A CB  1 
ATOM   1523 C  CG  . ASP   A 1 232 ? -28.542 -28.573 -32.113 1.00 30.15  ? 495  ASP   A CG  1 
ATOM   1524 O  OD1 . ASP   A 1 232 ? -29.368 -29.375 -31.730 1.00 36.33  ? 495  ASP   A OD1 1 
ATOM   1525 O  OD2 . ASP   A 1 232 ? -28.702 -27.335 -32.088 1.00 29.44  ? 495  ASP   A OD2 1 
ATOM   1526 N  N   . HIS   A 1 233 ? -24.713 -31.628 -31.638 1.00 29.81  ? 496  HIS   A N   1 
ATOM   1527 C  CA  . HIS   A 1 233 ? -23.601 -32.522 -32.051 1.00 30.64  ? 496  HIS   A CA  1 
ATOM   1528 C  C   . HIS   A 1 233 ? -22.550 -31.748 -32.863 1.00 24.46  ? 496  HIS   A C   1 
ATOM   1529 O  O   . HIS   A 1 233 ? -22.076 -32.286 -33.873 1.00 29.56  ? 496  HIS   A O   1 
ATOM   1530 C  CB  . HIS   A 1 233 ? -24.144 -33.717 -32.840 1.00 32.62  ? 496  HIS   A CB  1 
ATOM   1531 C  CG  . HIS   A 1 233 ? -25.252 -34.443 -32.167 1.00 41.81  ? 496  HIS   A CG  1 
ATOM   1532 N  ND1 . HIS   A 1 233 ? -25.057 -35.157 -31.002 1.00 43.86  ? 496  HIS   A ND1 1 
ATOM   1533 C  CD2 . HIS   A 1 233 ? -26.578 -34.535 -32.481 1.00 44.84  ? 496  HIS   A CD2 1 
ATOM   1534 C  CE1 . HIS   A 1 233 ? -26.225 -35.666 -30.612 1.00 45.56  ? 496  HIS   A CE1 1 
ATOM   1535 N  NE2 . HIS   A 1 233 ? -27.162 -35.314 -31.525 1.00 44.93  ? 496  HIS   A NE2 1 
ATOM   1536 N  N   . TRP   A 1 234 ? -22.137 -30.598 -32.378 1.00 25.17  ? 497  TRP   A N   1 
ATOM   1537 C  CA  . TRP   A 1 234 ? -21.082 -29.769 -33.029 1.00 25.43  ? 497  TRP   A CA  1 
ATOM   1538 C  C   . TRP   A 1 234 ? -19.743 -30.558 -33.067 1.00 27.31  ? 497  TRP   A C   1 
ATOM   1539 O  O   . TRP   A 1 234 ? -18.972 -30.412 -34.057 1.00 24.41  ? 497  TRP   A O   1 
ATOM   1540 C  CB  . TRP   A 1 234 ? -20.946 -28.431 -32.316 1.00 25.48  ? 497  TRP   A CB  1 
ATOM   1541 C  CG  . TRP   A 1 234 ? -21.975 -27.437 -32.784 1.00 31.63  ? 497  TRP   A CG  1 
ATOM   1542 C  CD1 . TRP   A 1 234 ? -23.336 -27.647 -32.892 1.00 29.38  ? 497  TRP   A CD1 1 
ATOM   1543 C  CD2 . TRP   A 1 234 ? -21.718 -26.161 -33.395 1.00 26.35  ? 497  TRP   A CD2 1 
ATOM   1544 N  NE1 . TRP   A 1 234 ? -23.941 -26.539 -33.419 1.00 30.18  ? 497  TRP   A NE1 1 
ATOM   1545 C  CE2 . TRP   A 1 234 ? -22.981 -25.619 -33.752 1.00 27.82  ? 497  TRP   A CE2 1 
ATOM   1546 C  CE3 . TRP   A 1 234 ? -20.567 -25.391 -33.599 1.00 29.68  ? 497  TRP   A CE3 1 
ATOM   1547 C  CZ2 . TRP   A 1 234 ? -23.113 -24.344 -34.285 1.00 29.69  ? 497  TRP   A CZ2 1 
ATOM   1548 C  CZ3 . TRP   A 1 234 ? -20.697 -24.141 -34.175 1.00 30.92  ? 497  TRP   A CZ3 1 
ATOM   1549 C  CH2 . TRP   A 1 234 ? -21.958 -23.632 -34.522 1.00 28.64  ? 497  TRP   A CH2 1 
ATOM   1550 N  N   . PHE   A 1 235 ? -19.515 -31.423 -32.082 1.00 26.37  ? 498  PHE   A N   1 
ATOM   1551 C  CA  . PHE   A 1 235 ? -18.262 -32.230 -31.951 1.00 26.46  ? 498  PHE   A CA  1 
ATOM   1552 C  C   . PHE   A 1 235 ? -18.376 -33.688 -32.416 1.00 28.35  ? 498  PHE   A C   1 
ATOM   1553 O  O   . PHE   A 1 235 ? -17.441 -34.509 -32.104 1.00 27.19  ? 498  PHE   A O   1 
ATOM   1554 C  CB  . PHE   A 1 235 ? -17.705 -31.996 -30.542 1.00 25.42  ? 498  PHE   A CB  1 
ATOM   1555 C  CG  . PHE   A 1 235 ? -17.345 -30.548 -30.326 1.00 26.00  ? 498  PHE   A CG  1 
ATOM   1556 C  CD1 . PHE   A 1 235 ? -16.260 -29.987 -30.976 1.00 28.56  ? 498  PHE   A CD1 1 
ATOM   1557 C  CD2 . PHE   A 1 235 ? -18.159 -29.725 -29.566 1.00 26.71  ? 498  PHE   A CD2 1 
ATOM   1558 C  CE1 . PHE   A 1 235 ? -15.976 -28.642 -30.851 1.00 26.67  ? 498  PHE   A CE1 1 
ATOM   1559 C  CE2 . PHE   A 1 235 ? -17.880 -28.368 -29.451 1.00 31.39  ? 498  PHE   A CE2 1 
ATOM   1560 C  CZ  . PHE   A 1 235 ? -16.787 -27.832 -30.085 1.00 30.93  ? 498  PHE   A CZ  1 
ATOM   1561 N  N   . SER   A 1 236 ? -19.436 -34.028 -33.163 0.50 26.94  ? 499  SER   A N   1 
ATOM   1562 C  CA  . SER   A 1 236 ? -19.525 -35.296 -33.934 0.50 26.61  ? 499  SER   A CA  1 
ATOM   1563 C  C   . SER   A 1 236 ? -18.298 -35.388 -34.842 0.50 26.12  ? 499  SER   A C   1 
ATOM   1564 O  O   . SER   A 1 236 ? -17.762 -34.322 -35.208 0.50 25.90  ? 499  SER   A O   1 
ATOM   1565 C  CB  . SER   A 1 236 ? -20.787 -35.346 -34.754 0.50 27.60  ? 499  SER   A CB  1 
ATOM   1566 O  OG  . SER   A 1 236 ? -20.759 -34.334 -35.755 0.50 26.44  ? 499  SER   A OG  1 
ATOM   1567 N  N   . ARG   A 1 237 ? -17.891 -36.592 -35.223 1.00 25.12  ? 500  ARG   A N   1 
ATOM   1568 C  CA  . ARG   A 1 237 ? -16.760 -36.743 -36.177 1.00 27.30  ? 500  ARG   A CA  1 
ATOM   1569 C  C   . ARG   A 1 237 ? -17.144 -36.194 -37.563 1.00 29.69  ? 500  ARG   A C   1 
ATOM   1570 O  O   . ARG   A 1 237 ? -16.286 -35.609 -38.213 1.00 28.12  ? 500  ARG   A O   1 
ATOM   1571 C  CB  . ARG   A 1 237 ? -16.287 -38.198 -36.244 1.00 27.08  ? 500  ARG   A CB  1 
ATOM   1572 C  CG  . ARG   A 1 237 ? -14.921 -38.371 -36.889 1.00 27.64  ? 500  ARG   A CG  1 
ATOM   1573 C  CD  . ARG   A 1 237 ? -14.193 -39.603 -36.397 1.00 26.41  ? 500  ARG   A CD  1 
ATOM   1574 N  NE  . ARG   A 1 237 ? -12.814 -39.602 -36.851 1.00 24.89  ? 500  ARG   A NE  1 
ATOM   1575 C  CZ  . ARG   A 1 237 ? -11.822 -38.979 -36.232 1.00 24.42  ? 500  ARG   A CZ  1 
ATOM   1576 N  NH1 . ARG   A 1 237 ? -12.055 -38.297 -35.125 1.00 23.60  ? 500  ARG   A NH1 1 
ATOM   1577 N  NH2 . ARG   A 1 237 ? -10.600 -39.033 -36.726 1.00 27.02  ? 500  ARG   A NH2 1 
ATOM   1578 N  N   . GLU   A 1 238 ? -18.406 -36.350 -37.963 0.50 29.69  ? 501  GLU   A N   1 
ATOM   1579 C  CA  . GLU   A 1 238 ? -18.866 -35.848 -39.284 0.50 30.51  ? 501  GLU   A CA  1 
ATOM   1580 C  C   . GLU   A 1 238 ? -18.704 -34.324 -39.352 0.50 28.16  ? 501  GLU   A C   1 
ATOM   1581 O  O   . GLU   A 1 238 ? -18.286 -33.835 -40.404 0.50 28.96  ? 501  GLU   A O   1 
ATOM   1582 C  CB  . GLU   A 1 238 ? -20.316 -36.268 -39.533 0.50 34.24  ? 501  GLU   A CB  1 
ATOM   1583 C  CG  . GLU   A 1 238 ? -20.894 -35.738 -40.831 0.50 37.14  ? 501  GLU   A CG  1 
ATOM   1584 C  CD  . GLU   A 1 238 ? -22.312 -36.199 -41.124 0.50 42.97  ? 501  GLU   A CD  1 
ATOM   1585 O  OE1 . GLU   A 1 238 ? -22.873 -35.760 -42.142 0.50 45.64  ? 501  GLU   A OE1 1 
ATOM   1586 O  OE2 . GLU   A 1 238 ? -22.850 -36.999 -40.336 0.50 43.03  ? 501  GLU   A OE2 1 
ATOM   1587 N  N   . ASN   A 1 239 ? -19.001 -33.615 -38.263 0.50 26.50  ? 502  ASN   A N   1 
ATOM   1588 C  CA  . ASN   A 1 239 ? -18.974 -32.129 -38.288 0.50 27.26  ? 502  ASN   A CA  1 
ATOM   1589 C  C   . ASN   A 1 239 ? -17.600 -31.553 -37.925 0.50 27.93  ? 502  ASN   A C   1 
ATOM   1590 O  O   . ASN   A 1 239 ? -17.250 -30.524 -38.514 0.50 26.26  ? 502  ASN   A O   1 
ATOM   1591 C  CB  . ASN   A 1 239 ? -20.012 -31.541 -37.330 0.50 26.43  ? 502  ASN   A CB  1 
ATOM   1592 C  CG  . ASN   A 1 239 ? -20.236 -30.061 -37.549 0.50 26.18  ? 502  ASN   A CG  1 
ATOM   1593 O  OD1 . ASN   A 1 239 ? -20.687 -29.654 -38.615 0.50 28.09  ? 502  ASN   A OD1 1 
ATOM   1594 N  ND2 . ASN   A 1 239 ? -19.927 -29.253 -36.549 0.50 23.46  ? 502  ASN   A ND2 1 
ATOM   1595 N  N   . SER   A 1 240 ? -16.860 -32.183 -37.006 1.00 26.92  ? 503  SER   A N   1 
ATOM   1596 C  CA  . SER   A 1 240 ? -15.583 -31.616 -36.486 1.00 25.09  ? 503  SER   A CA  1 
ATOM   1597 C  C   . SER   A 1 240 ? -14.339 -32.325 -37.045 1.00 22.42  ? 503  SER   A C   1 
ATOM   1598 O  O   . SER   A 1 240 ? -13.266 -31.767 -36.868 1.00 27.02  ? 503  SER   A O   1 
ATOM   1599 C  CB  . SER   A 1 240 ? -15.598 -31.687 -34.983 1.00 27.02  ? 503  SER   A CB  1 
ATOM   1600 O  OG  . SER   A 1 240 ? -15.589 -33.031 -34.541 1.00 24.41  ? 503  SER   A OG  1 
ATOM   1601 N  N   . LEU   A 1 241 ? -14.490 -33.513 -37.631 1.00 25.71  ? 504  LEU   A N   1 
ATOM   1602 C  CA  . LEU   A 1 241 ? -13.378 -34.310 -38.232 1.00 27.78  ? 504  LEU   A CA  1 
ATOM   1603 C  C   . LEU   A 1 241 ? -12.454 -34.920 -37.162 1.00 27.87  ? 504  LEU   A C   1 
ATOM   1604 O  O   . LEU   A 1 241 ? -12.059 -36.068 -37.334 1.00 27.28  ? 504  LEU   A O   1 
ATOM   1605 C  CB  . LEU   A 1 241 ? -12.597 -33.446 -39.228 1.00 29.09  ? 504  LEU   A CB  1 
ATOM   1606 C  CG  . LEU   A 1 241 ? -13.424 -32.780 -40.326 1.00 37.42  ? 504  LEU   A CG  1 
ATOM   1607 C  CD1 . LEU   A 1 241 ? -12.521 -32.193 -41.397 1.00 38.50  ? 504  LEU   A CD1 1 
ATOM   1608 C  CD2 . LEU   A 1 241 ? -14.400 -33.763 -40.947 1.00 40.91  ? 504  LEU   A CD2 1 
ATOM   1609 N  N   . SER   A 1 242 ? -12.106 -34.157 -36.129 1.00 25.55  ? 505  SER   A N   1 
ATOM   1610 C  CA  . SER   A 1 242 ? -11.230 -34.652 -35.036 1.00 23.50  ? 505  SER   A CA  1 
ATOM   1611 C  C   . SER   A 1 242 ? -12.071 -35.197 -33.878 1.00 25.09  ? 505  SER   A C   1 
ATOM   1612 O  O   . SER   A 1 242 ? -11.568 -36.034 -33.147 1.00 22.15  ? 505  SER   A O   1 
ATOM   1613 C  CB  . SER   A 1 242 ? -10.317 -33.543 -34.561 1.00 25.74  ? 505  SER   A CB  1 
ATOM   1614 O  OG  . SER   A 1 242 ? -9.517  -33.028 -35.602 1.00 26.62  ? 505  SER   A OG  1 
ATOM   1615 N  N   . GLY   A 1 243 ? -13.309 -34.722 -33.738 1.00 25.85  ? 506  GLY   A N   1 
ATOM   1616 C  CA  . GLY   A 1 243 ? -14.147 -35.082 -32.585 1.00 23.94  ? 506  GLY   A CA  1 
ATOM   1617 C  C   . GLY   A 1 243 ? -14.658 -36.515 -32.666 1.00 23.47  ? 506  GLY   A C   1 
ATOM   1618 O  O   . GLY   A 1 243 ? -14.625 -37.145 -33.738 1.00 25.47  ? 506  GLY   A O   1 
ATOM   1619 N  N   . VAL   A 1 244 ? -15.173 -36.990 -31.541 1.00 23.51  ? 507  VAL   A N   1 
ATOM   1620 C  CA  . VAL   A 1 244 ? -15.799 -38.330 -31.388 1.00 27.14  ? 507  VAL   A CA  1 
ATOM   1621 C  C   . VAL   A 1 244 ? -17.083 -38.234 -30.540 1.00 26.47  ? 507  VAL   A C   1 
ATOM   1622 O  O   . VAL   A 1 244 ? -17.569 -39.261 -30.064 1.00 25.16  ? 507  VAL   A O   1 
ATOM   1623 C  CB  . VAL   A 1 244 ? -14.806 -39.344 -30.787 1.00 25.70  ? 507  VAL   A CB  1 
ATOM   1624 C  CG1 . VAL   A 1 244 ? -13.637 -39.618 -31.715 1.00 25.52  ? 507  VAL   A CG1 1 
ATOM   1625 C  CG2 . VAL   A 1 244 ? -14.348 -38.930 -29.401 1.00 27.41  ? 507  VAL   A CG2 1 
ATOM   1626 N  N   . GLU   A 1 245 ? -17.680 -37.054 -30.422 1.00 25.26  ? 508  GLU   A N   1 
ATOM   1627 C  CA  . GLU   A 1 245 ? -18.918 -36.901 -29.591 1.00 32.55  ? 508  GLU   A CA  1 
ATOM   1628 C  C   . GLU   A 1 245 ? -20.009 -37.797 -30.176 1.00 28.19  ? 508  GLU   A C   1 
ATOM   1629 O  O   . GLU   A 1 245 ? -20.217 -37.790 -31.381 1.00 28.23  ? 508  GLU   A O   1 
ATOM   1630 C  CB  . GLU   A 1 245 ? -19.374 -35.448 -29.534 1.00 32.79  ? 508  GLU   A CB  1 
ATOM   1631 C  CG  . GLU   A 1 245 ? -20.454 -35.210 -28.471 1.00 40.43  ? 508  GLU   A CG  1 
ATOM   1632 C  CD  . GLU   A 1 245 ? -21.876 -35.481 -28.947 1.00 42.78  ? 508  GLU   A CD  1 
ATOM   1633 O  OE1 . GLU   A 1 245 ? -22.249 -34.941 -29.984 1.00 54.49  ? 508  GLU   A OE1 1 
ATOM   1634 O  OE2 . GLU   A 1 245 ? -22.590 -36.269 -28.294 1.00 54.13  ? 508  GLU   A OE2 1 
ATOM   1635 N  N   . GLY   A 1 246 ? -20.644 -38.610 -29.329 0.50 31.90  ? 509  GLY   A N   1 
ATOM   1636 C  CA  . GLY   A 1 246 ? -21.757 -39.499 -29.726 0.50 32.90  ? 509  GLY   A CA  1 
ATOM   1637 C  C   . GLY   A 1 246 ? -21.284 -40.786 -30.375 0.50 33.03  ? 509  GLY   A C   1 
ATOM   1638 O  O   . GLY   A 1 246 ? -22.145 -41.597 -30.771 0.50 32.68  ? 509  GLY   A O   1 
ATOM   1639 N  N   . GLU   A 1 247 ? -19.972 -41.000 -30.490 0.50 33.99  ? 510  GLU   A N   1 
ATOM   1640 C  CA  . GLU   A 1 247 ? -19.454 -42.126 -31.306 0.50 36.28  ? 510  GLU   A CA  1 
ATOM   1641 C  C   . GLU   A 1 247 ? -19.824 -43.441 -30.619 0.50 36.85  ? 510  GLU   A C   1 
ATOM   1642 O  O   . GLU   A 1 247 ? -20.566 -44.228 -31.244 0.50 42.50  ? 510  GLU   A O   1 
ATOM   1643 C  CB  . GLU   A 1 247 ? -17.960 -41.975 -31.593 0.50 37.47  ? 510  GLU   A CB  1 
ATOM   1644 C  CG  . GLU   A 1 247 ? -17.709 -40.985 -32.717 0.50 39.64  ? 510  GLU   A CG  1 
ATOM   1645 C  CD  . GLU   A 1 247 ? -18.602 -41.206 -33.928 0.50 44.21  ? 510  GLU   A CD  1 
ATOM   1646 O  OE1 . GLU   A 1 247 ? -18.642 -42.350 -34.399 0.50 42.63  ? 510  GLU   A OE1 1 
ATOM   1647 O  OE2 . GLU   A 1 247 ? -19.280 -40.236 -34.379 0.50 51.36  ? 510  GLU   A OE2 1 
ATOM   1648 N  N   . GLY   A 1 248 ? -19.363 -43.655 -29.386 0.50 33.50  ? 511  GLY   A N   1 
ATOM   1649 C  CA  . GLY   A 1 248 ? -19.579 -44.929 -28.675 0.50 33.90  ? 511  GLY   A CA  1 
ATOM   1650 C  C   . GLY   A 1 248 ? -18.312 -45.770 -28.653 0.50 32.02  ? 511  GLY   A C   1 
ATOM   1651 O  O   . GLY   A 1 248 ? -17.537 -45.742 -29.617 0.50 28.21  ? 511  GLY   A O   1 
ATOM   1652 N  N   A LEU   A 1 249 ? -18.131 -46.553 -27.606 0.25 31.23  ? 512  LEU   A N   1 
ATOM   1653 N  N   B LEU   A 1 249 ? -18.080 -46.497 -27.538 0.25 33.78  ? 512  LEU   A N   1 
ATOM   1654 C  CA  A LEU   A 1 249 ? -16.846 -47.224 -27.331 0.25 30.43  ? 512  LEU   A CA  1 
ATOM   1655 C  CA  B LEU   A 1 249 ? -16.835 -47.279 -27.319 0.25 34.28  ? 512  LEU   A CA  1 
ATOM   1656 C  C   A LEU   A 1 249 ? -16.575 -48.322 -28.369 0.25 31.91  ? 512  LEU   A C   1 
ATOM   1657 C  C   B LEU   A 1 249 ? -16.563 -48.174 -28.524 0.25 33.77  ? 512  LEU   A C   1 
ATOM   1658 O  O   A LEU   A 1 249 ? -15.396 -48.657 -28.556 0.25 35.24  ? 512  LEU   A O   1 
ATOM   1659 O  O   B LEU   A 1 249 ? -15.390 -48.242 -28.924 0.25 34.06  ? 512  LEU   A O   1 
ATOM   1660 C  CB  A LEU   A 1 249 ? -16.918 -47.747 -25.897 0.25 30.59  ? 512  LEU   A CB  1 
ATOM   1661 C  CB  B LEU   A 1 249 ? -16.949 -48.126 -26.049 0.25 38.02  ? 512  LEU   A CB  1 
ATOM   1662 C  CG  A LEU   A 1 249 ? -15.676 -48.462 -25.402 0.25 26.96  ? 512  LEU   A CG  1 
ATOM   1663 C  CG  B LEU   A 1 249 ? -16.408 -47.479 -24.780 0.25 36.52  ? 512  LEU   A CG  1 
ATOM   1664 C  CD1 A LEU   A 1 249 ? -14.470 -47.527 -25.408 0.25 26.45  ? 512  LEU   A CD1 1 
ATOM   1665 C  CD1 B LEU   A 1 249 ? -16.535 -48.434 -23.608 0.25 35.68  ? 512  LEU   A CD1 1 
ATOM   1666 C  CD2 A LEU   A 1 249 ? -15.935 -49.007 -24.015 0.25 26.68  ? 512  LEU   A CD2 1 
ATOM   1667 C  CD2 B LEU   A 1 249 ? -14.961 -47.040 -24.969 0.25 36.63  ? 512  LEU   A CD2 1 
ATOM   1668 N  N   . HIS   A 1 250 ? -17.614 -48.818 -29.052 0.50 31.59  ? 513  HIS   A N   1 
ATOM   1669 C  CA  . HIS   A 1 250 ? -17.546 -49.827 -30.144 0.50 31.58  ? 513  HIS   A CA  1 
ATOM   1670 C  C   . HIS   A 1 250 ? -17.124 -49.190 -31.474 0.50 30.63  ? 513  HIS   A C   1 
ATOM   1671 O  O   . HIS   A 1 250 ? -17.027 -49.927 -32.477 0.50 30.54  ? 513  HIS   A O   1 
ATOM   1672 C  CB  . HIS   A 1 250 ? -18.906 -50.516 -30.331 0.50 32.90  ? 513  HIS   A CB  1 
ATOM   1673 C  CG  . HIS   A 1 250 ? -20.006 -49.558 -30.636 0.50 32.27  ? 513  HIS   A CG  1 
ATOM   1674 N  ND1 . HIS   A 1 250 ? -20.506 -48.694 -29.680 0.50 32.72  ? 513  HIS   A ND1 1 
ATOM   1675 C  CD2 . HIS   A 1 250 ? -20.693 -49.315 -31.774 0.50 33.48  ? 513  HIS   A CD2 1 
ATOM   1676 C  CE1 . HIS   A 1 250 ? -21.462 -47.958 -30.218 0.50 33.42  ? 513  HIS   A CE1 1 
ATOM   1677 N  NE2 . HIS   A 1 250 ? -21.595 -48.323 -31.507 0.50 35.05  ? 513  HIS   A NE2 1 
ATOM   1678 N  N   . LYS   A 1 251 ? -16.954 -47.868 -31.509 0.50 28.76  ? 514  LYS   A N   1 
ATOM   1679 C  CA  . LYS   A 1 251 ? -16.520 -47.138 -32.729 0.50 28.90  ? 514  LYS   A CA  1 
ATOM   1680 C  C   . LYS   A 1 251 ? -15.099 -46.585 -32.555 0.50 25.82  ? 514  LYS   A C   1 
ATOM   1681 O  O   . LYS   A 1 251 ? -14.423 -46.392 -33.585 0.50 25.35  ? 514  LYS   A O   1 
ATOM   1682 C  CB  . LYS   A 1 251 ? -17.510 -46.012 -33.036 0.50 32.56  ? 514  LYS   A CB  1 
ATOM   1683 C  CG  . LYS   A 1 251 ? -18.961 -46.470 -33.122 0.50 35.77  ? 514  LYS   A CG  1 
ATOM   1684 C  CD  . LYS   A 1 251 ? -19.496 -46.517 -34.514 0.50 41.04  ? 514  LYS   A CD  1 
ATOM   1685 C  CE  . LYS   A 1 251 ? -19.885 -45.146 -35.017 0.50 42.71  ? 514  LYS   A CE  1 
ATOM   1686 N  NZ  . LYS   A 1 251 ? -21.065 -45.224 -35.905 0.50 46.28  ? 514  LYS   A NZ  1 
ATOM   1687 N  N   . LEU   A 1 252 ? -14.664 -46.317 -31.321 1.00 23.43  ? 515  LEU   A N   1 
ATOM   1688 C  CA  . LEU   A 1 252 ? -13.389 -45.579 -31.093 1.00 24.15  ? 515  LEU   A CA  1 
ATOM   1689 C  C   . LEU   A 1 252 ? -12.196 -46.352 -31.653 1.00 23.20  ? 515  LEU   A C   1 
ATOM   1690 O  O   . LEU   A 1 252 ? -11.285 -45.699 -32.220 1.00 22.25  ? 515  LEU   A O   1 
ATOM   1691 C  CB  . LEU   A 1 252 ? -13.200 -45.272 -29.621 1.00 24.50  ? 515  LEU   A CB  1 
ATOM   1692 C  CG  . LEU   A 1 252 ? -14.263 -44.389 -28.978 1.00 24.06  ? 515  LEU   A CG  1 
ATOM   1693 C  CD1 . LEU   A 1 252 ? -13.858 -44.121 -27.540 1.00 26.62  ? 515  LEU   A CD1 1 
ATOM   1694 C  CD2 . LEU   A 1 252 ? -14.440 -43.083 -29.718 1.00 26.83  ? 515  LEU   A CD2 1 
ATOM   1695 N  N   . GLY   A 1 253 ? -12.195 -47.685 -31.534 1.00 22.07  ? 516  GLY   A N   1 
ATOM   1696 C  CA  . GLY   A 1 253 ? -11.057 -48.477 -32.055 1.00 23.34  ? 516  GLY   A CA  1 
ATOM   1697 C  C   . GLY   A 1 253 ? -11.020 -48.425 -33.584 1.00 26.03  ? 516  GLY   A C   1 
ATOM   1698 O  O   . GLY   A 1 253 ? -9.899  -48.231 -34.179 1.00 24.07  ? 516  GLY   A O   1 
ATOM   1699 N  N   . TYR   A 1 254 ? -12.185 -48.526 -34.237 1.00 22.43  ? 517  TYR   A N   1 
ATOM   1700 C  CA  . TYR   A 1 254 ? -12.226 -48.391 -35.708 1.00 23.54  ? 517  TYR   A CA  1 
ATOM   1701 C  C   . TYR   A 1 254 ? -11.747 -46.998 -36.136 1.00 24.20  ? 517  TYR   A C   1 
ATOM   1702 O  O   . TYR   A 1 254 ? -11.061 -46.876 -37.180 1.00 25.59  ? 517  TYR   A O   1 
ATOM   1703 C  CB  . TYR   A 1 254 ? -13.621 -48.632 -36.251 1.00 26.08  ? 517  TYR   A CB  1 
ATOM   1704 C  CG  . TYR   A 1 254 ? -14.083 -50.057 -36.241 1.00 22.94  ? 517  TYR   A CG  1 
ATOM   1705 C  CD1 . TYR   A 1 254 ? -13.549 -50.985 -37.134 1.00 26.38  ? 517  TYR   A CD1 1 
ATOM   1706 C  CD2 . TYR   A 1 254 ? -15.070 -50.470 -35.361 1.00 23.62  ? 517  TYR   A CD2 1 
ATOM   1707 C  CE1 . TYR   A 1 254 ? -13.988 -52.307 -37.141 1.00 25.08  ? 517  TYR   A CE1 1 
ATOM   1708 C  CE2 . TYR   A 1 254 ? -15.540 -51.771 -35.375 1.00 23.91  ? 517  TYR   A CE2 1 
ATOM   1709 C  CZ  . TYR   A 1 254 ? -15.009 -52.688 -36.271 1.00 25.26  ? 517  TYR   A CZ  1 
ATOM   1710 O  OH  . TYR   A 1 254 ? -15.513 -53.958 -36.271 1.00 25.89  ? 517  TYR   A OH  1 
ATOM   1711 N  N   . ILE   A 1 255 ? -12.085 -45.968 -35.369 1.00 25.19  ? 518  ILE   A N   1 
ATOM   1712 C  CA  . ILE   A 1 255 ? -11.660 -44.590 -35.686 1.00 26.10  ? 518  ILE   A CA  1 
ATOM   1713 C  C   . ILE   A 1 255 ? -10.127 -44.488 -35.560 1.00 27.70  ? 518  ILE   A C   1 
ATOM   1714 O  O   . ILE   A 1 255 ? -9.496  -43.905 -36.458 1.00 26.52  ? 518  ILE   A O   1 
ATOM   1715 C  CB  . ILE   A 1 255 ? -12.408 -43.579 -34.813 1.00 25.28  ? 518  ILE   A CB  1 
ATOM   1716 C  CG1 . ILE   A 1 255 ? -13.874 -43.462 -35.246 1.00 24.65  ? 518  ILE   A CG1 1 
ATOM   1717 C  CG2 . ILE   A 1 255 ? -11.668 -42.241 -34.795 1.00 26.39  ? 518  ILE   A CG2 1 
ATOM   1718 C  CD1 . ILE   A 1 255 ? -14.759 -42.769 -34.218 1.00 26.02  ? 518  ILE   A CD1 1 
ATOM   1719 N  N   . LEU   A 1 256 ? -9.513  -45.035 -34.514 1.00 25.21  ? 519  LEU   A N   1 
ATOM   1720 C  CA  . LEU   A 1 256 ? -8.038  -45.012 -34.373 1.00 24.85  ? 519  LEU   A CA  1 
ATOM   1721 C  C   . LEU   A 1 256 ? -7.374  -45.812 -35.494 1.00 27.40  ? 519  LEU   A C   1 
ATOM   1722 O  O   . LEU   A 1 256 ? -6.317  -45.347 -35.983 1.00 28.50  ? 519  LEU   A O   1 
ATOM   1723 C  CB  . LEU   A 1 256 ? -7.624  -45.575 -33.016 1.00 26.31  ? 519  LEU   A CB  1 
ATOM   1724 C  CG  . LEU   A 1 256 ? -7.973  -44.742 -31.789 1.00 30.94  ? 519  LEU   A CG  1 
ATOM   1725 C  CD1 . LEU   A 1 256 ? -7.290  -45.384 -30.587 1.00 33.44  ? 519  LEU   A CD1 1 
ATOM   1726 C  CD2 . LEU   A 1 256 ? -7.535  -43.287 -31.961 1.00 31.01  ? 519  LEU   A CD2 1 
ATOM   1727 N  N   . ARG   A 1 257 ? -7.974  -46.930 -35.951 1.00 24.79  ? 520  ARG   A N   1 
ATOM   1728 C  CA  . ARG   A 1 257 ? -7.377  -47.742 -37.050 1.00 28.65  ? 520  ARG   A CA  1 
ATOM   1729 C  C   . ARG   A 1 257 ? -7.463  -46.916 -38.342 1.00 28.51  ? 520  ARG   A C   1 
ATOM   1730 O  O   . ARG   A 1 257 ? -6.501  -46.935 -39.149 1.00 27.86  ? 520  ARG   A O   1 
ATOM   1731 C  CB  . ARG   A 1 257 ? -8.043  -49.115 -37.176 1.00 27.80  ? 520  ARG   A CB  1 
ATOM   1732 C  CG  . ARG   A 1 257 ? -7.432  -50.002 -38.256 1.00 28.42  ? 520  ARG   A CG  1 
ATOM   1733 C  CD  . ARG   A 1 257 ? -8.191  -51.306 -38.407 1.00 27.52  ? 520  ARG   A CD  1 
ATOM   1734 N  NE  . ARG   A 1 257 ? -9.527  -51.133 -38.976 1.00 27.63  ? 520  ARG   A NE  1 
ATOM   1735 C  CZ  . ARG   A 1 257 ? -10.290 -52.144 -39.416 1.00 26.93  ? 520  ARG   A CZ  1 
ATOM   1736 N  NH1 . ARG   A 1 257 ? -9.878  -53.383 -39.276 1.00 29.73  ? 520  ARG   A NH1 1 
ATOM   1737 N  NH2 . ARG   A 1 257 ? -11.454 -51.911 -39.958 1.00 28.02  ? 520  ARG   A NH2 1 
ATOM   1738 N  N   . ASP   A 1 258 ? -8.524  -46.148 -38.528 1.00 25.48  ? 521  ASP   A N   1 
ATOM   1739 C  CA  . ASP   A 1 258 ? -8.642  -45.283 -39.751 1.00 27.28  ? 521  ASP   A CA  1 
ATOM   1740 C  C   . ASP   A 1 258 ? -7.564  -44.172 -39.715 1.00 30.34  ? 521  ASP   A C   1 
ATOM   1741 O  O   . ASP   A 1 258 ? -6.951  -43.939 -40.724 1.00 31.13  ? 521  ASP   A O   1 
ATOM   1742 C  CB  . ASP   A 1 258 ? -10.027 -44.673 -39.932 1.00 28.13  ? 521  ASP   A CB  1 
ATOM   1743 C  CG  . ASP   A 1 258 ? -11.045 -45.589 -40.598 1.00 30.11  ? 521  ASP   A CG  1 
ATOM   1744 O  OD1 . ASP   A 1 258 ? -10.651 -46.687 -41.070 1.00 30.85  ? 521  ASP   A OD1 1 
ATOM   1745 O  OD2 . ASP   A 1 258 ? -12.220 -45.221 -40.589 1.00 34.01  ? 521  ASP   A OD2 1 
ATOM   1746 N  N   . VAL   A 1 259 ? -7.300  -43.551 -38.582 1.00 27.24  ? 522  VAL   A N   1 
ATOM   1747 C  CA  . VAL   A 1 259 ? -6.189  -42.568 -38.426 1.00 27.86  ? 522  VAL   A CA  1 
ATOM   1748 C  C   . VAL   A 1 259 ? -4.854  -43.255 -38.760 1.00 31.00  ? 522  VAL   A C   1 
ATOM   1749 O  O   . VAL   A 1 259 ? -4.046  -42.662 -39.495 1.00 30.78  ? 522  VAL   A O   1 
ATOM   1750 C  CB  . VAL   A 1 259 ? -6.190  -41.978 -37.006 1.00 29.89  ? 522  VAL   A CB  1 
ATOM   1751 C  CG1 . VAL   A 1 259 ? -4.917  -41.171 -36.740 1.00 31.97  ? 522  VAL   A CG1 1 
ATOM   1752 C  CG2 . VAL   A 1 259 ? -7.422  -41.121 -36.783 1.00 30.54  ? 522  VAL   A CG2 1 
ATOM   1753 N  N   . SER   A 1 260 ? -4.643  -44.488 -38.307 1.00 28.87  ? 523  SER   A N   1 
ATOM   1754 C  CA  . SER   A 1 260 ? -3.387  -45.250 -38.509 1.00 28.29  ? 523  SER   A CA  1 
ATOM   1755 C  C   . SER   A 1 260 ? -3.115  -45.453 -40.008 1.00 29.55  ? 523  SER   A C   1 
ATOM   1756 O  O   . SER   A 1 260 ? -1.941  -45.561 -40.361 1.00 31.50  ? 523  SER   A O   1 
ATOM   1757 C  CB  . SER   A 1 260 ? -3.400  -46.570 -37.807 1.00 29.16  ? 523  SER   A CB  1 
ATOM   1758 O  OG  . SER   A 1 260 ? -3.993  -47.574 -38.624 1.00 31.85  ? 523  SER   A OG  1 
ATOM   1759 N  N   . LYS   A 1 261 ? -4.136  -45.423 -40.854 1.00 27.93  ? 524  LYS   A N   1 
ATOM   1760 C  CA  . LYS   A 1 261 ? -3.999  -45.665 -42.311 1.00 35.11  ? 524  LYS   A CA  1 
ATOM   1761 C  C   . LYS   A 1 261 ? -3.423  -44.449 -43.048 1.00 35.84  ? 524  LYS   A C   1 
ATOM   1762 O  O   . LYS   A 1 261 ? -3.021  -44.625 -44.205 1.00 39.13  ? 524  LYS   A O   1 
ATOM   1763 C  CB  . LYS   A 1 261 ? -5.342  -46.016 -42.936 1.00 39.12  ? 524  LYS   A CB  1 
ATOM   1764 C  CG  . LYS   A 1 261 ? -5.806  -47.413 -42.592 1.00 46.55  ? 524  LYS   A CG  1 
ATOM   1765 C  CD  . LYS   A 1 261 ? -7.219  -47.620 -43.027 1.00 54.07  ? 524  LYS   A CD  1 
ATOM   1766 C  CE  . LYS   A 1 261 ? -7.736  -48.980 -42.626 1.00 60.78  ? 524  LYS   A CE  1 
ATOM   1767 N  NZ  . LYS   A 1 261 ? -9.216  -48.966 -42.656 1.00 77.12  ? 524  LYS   A NZ  1 
ATOM   1768 N  N   . LYS   A 1 262 ? -3.440  -43.274 -42.440 1.00 33.99  ? 525  LYS   A N   1 
ATOM   1769 C  CA  . LYS   A 1 262 ? -2.831  -42.067 -43.037 1.00 38.80  ? 525  LYS   A CA  1 
ATOM   1770 C  C   . LYS   A 1 262 ? -1.327  -42.303 -43.152 1.00 41.99  ? 525  LYS   A C   1 
ATOM   1771 O  O   . LYS   A 1 262 ? -0.750  -42.912 -42.260 1.00 37.66  ? 525  LYS   A O   1 
ATOM   1772 C  CB  . LYS   A 1 262 ? -3.146  -40.836 -42.192 1.00 36.38  ? 525  LYS   A CB  1 
ATOM   1773 C  CG  . LYS   A 1 262 ? -4.638  -40.534 -42.149 1.00 40.13  ? 525  LYS   A CG  1 
ATOM   1774 C  CD  . LYS   A 1 262 ? -5.013  -39.128 -42.423 1.00 44.11  ? 525  LYS   A CD  1 
ATOM   1775 C  CE  . LYS   A 1 262 ? -6.490  -38.956 -42.663 1.00 44.98  ? 525  LYS   A CE  1 
ATOM   1776 N  NZ  . LYS   A 1 262 ? -6.706  -37.833 -43.612 1.00 50.11  ? 525  LYS   A NZ  1 
ATOM   1777 N  N   . GLU   A 1 263 ? -0.703  -41.796 -44.202 1.00 37.65  ? 526  GLU   A N   1 
ATOM   1778 C  CA  . GLU   A 1 263 ? 0.774   -41.704 -44.244 1.00 38.96  ? 526  GLU   A CA  1 
ATOM   1779 C  C   . GLU   A 1 263 ? 1.194   -40.710 -43.150 1.00 34.72  ? 526  GLU   A C   1 
ATOM   1780 O  O   . GLU   A 1 263 ? 0.526   -39.691 -42.983 1.00 36.82  ? 526  GLU   A O   1 
ATOM   1781 C  CB  . GLU   A 1 263 ? 1.242   -41.266 -45.638 1.00 43.76  ? 526  GLU   A CB  1 
ATOM   1782 C  CG  . GLU   A 1 263 ? 0.903   -42.254 -46.757 1.00 47.92  ? 526  GLU   A CG  1 
ATOM   1783 C  CD  . GLU   A 1 263 ? 1.575   -43.625 -46.668 1.00 63.54  ? 526  GLU   A CD  1 
ATOM   1784 O  OE1 . GLU   A 1 263 ? 2.797   -43.692 -46.359 1.00 66.96  ? 526  GLU   A OE1 1 
ATOM   1785 O  OE2 . GLU   A 1 263 ? 0.875   -44.644 -46.897 1.00 62.52  ? 526  GLU   A OE2 1 
ATOM   1786 N  N   . GLY   A 1 264 ? 2.231   -41.024 -42.396 1.00 31.62  ? 527  GLY   A N   1 
ATOM   1787 C  CA  . GLY   A 1 264 ? 2.890   -40.005 -41.565 1.00 35.47  ? 527  GLY   A CA  1 
ATOM   1788 C  C   . GLY   A 1 264 ? 3.729   -40.655 -40.495 1.00 38.04  ? 527  GLY   A C   1 
ATOM   1789 O  O   . GLY   A 1 264 ? 4.152   -41.773 -40.693 1.00 34.26  ? 527  GLY   A O   1 
ATOM   1790 N  N   . GLY   A 1 265 ? 3.951   -39.963 -39.382 1.00 40.30  ? 528  GLY   A N   1 
ATOM   1791 C  CA  . GLY   A 1 265 ? 4.860   -40.441 -38.334 1.00 38.18  ? 528  GLY   A CA  1 
ATOM   1792 C  C   . GLY   A 1 265 ? 4.157   -41.338 -37.324 1.00 39.99  ? 528  GLY   A C   1 
ATOM   1793 O  O   . GLY   A 1 265 ? 3.151   -41.958 -37.666 1.00 36.57  ? 528  GLY   A O   1 
ATOM   1794 N  N   . ALA   A 1 266 ? 4.736   -41.448 -36.141 1.00 33.26  ? 529  ALA   A N   1 
ATOM   1795 C  CA  . ALA   A 1 266 ? 4.172   -42.198 -35.008 1.00 29.44  ? 529  ALA   A CA  1 
ATOM   1796 C  C   . ALA   A 1 266 ? 2.807   -41.623 -34.649 1.00 28.97  ? 529  ALA   A C   1 
ATOM   1797 O  O   . ALA   A 1 266 ? 2.431   -40.518 -35.123 1.00 27.54  ? 529  ALA   A O   1 
ATOM   1798 C  CB  . ALA   A 1 266 ? 5.120   -42.184 -33.839 1.00 27.93  ? 529  ALA   A CB  1 
ATOM   1799 N  N   . MET   A 1 267 ? 2.046   -42.367 -33.841 1.00 27.30  ? 530  MET   A N   1 
ATOM   1800 C  CA  . MET   A 1 267 ? 0.817   -41.847 -33.200 1.00 26.66  ? 530  MET   A CA  1 
ATOM   1801 C  C   . MET   A 1 267 ? 1.174   -41.291 -31.825 1.00 26.41  ? 530  MET   A C   1 
ATOM   1802 O  O   . MET   A 1 267 ? 1.767   -41.999 -31.016 1.00 34.22  ? 530  MET   A O   1 
ATOM   1803 C  CB  . MET   A 1 267 ? -0.241  -42.975 -33.135 1.00 28.65  ? 530  MET   A CB  1 
ATOM   1804 C  CG  . MET   A 1 267 ? -0.659  -43.376 -34.525 1.00 29.71  ? 530  MET   A CG  1 
ATOM   1805 S  SD  . MET   A 1 267 ? -1.990  -44.636 -34.673 1.00 35.91  ? 530  MET   A SD  1 
ATOM   1806 C  CE  . MET   A 1 267 ? -3.418  -43.700 -34.158 1.00 36.52  ? 530  MET   A CE  1 
ATOM   1807 N  N   . TYR   A 1 268 ? 0.870   -40.026 -31.577 1.00 23.74  ? 531  TYR   A N   1 
ATOM   1808 C  CA  . TYR   A 1 268 ? 1.178   -39.342 -30.313 1.00 23.01  ? 531  TYR   A CA  1 
ATOM   1809 C  C   . TYR   A 1 268 ? -0.089  -39.251 -29.494 1.00 22.66  ? 531  TYR   A C   1 
ATOM   1810 O  O   . TYR   A 1 268 ? -1.190  -38.860 -30.036 1.00 26.53  ? 531  TYR   A O   1 
ATOM   1811 C  CB  . TYR   A 1 268 ? 1.815   -37.986 -30.625 1.00 22.60  ? 531  TYR   A CB  1 
ATOM   1812 C  CG  . TYR   A 1 268 ? 3.140   -38.152 -31.337 1.00 26.78  ? 531  TYR   A CG  1 
ATOM   1813 C  CD1 . TYR   A 1 268 ? 3.208   -38.317 -32.709 1.00 24.46  ? 531  TYR   A CD1 1 
ATOM   1814 C  CD2 . TYR   A 1 268 ? 4.326   -38.256 -30.630 1.00 30.12  ? 531  TYR   A CD2 1 
ATOM   1815 C  CE1 . TYR   A 1 268 ? 4.425   -38.524 -33.353 1.00 25.91  ? 531  TYR   A CE1 1 
ATOM   1816 C  CE2 . TYR   A 1 268 ? 5.540   -38.487 -31.256 1.00 28.56  ? 531  TYR   A CE2 1 
ATOM   1817 C  CZ  . TYR   A 1 268 ? 5.603   -38.587 -32.630 1.00 30.83  ? 531  TYR   A CZ  1 
ATOM   1818 O  OH  . TYR   A 1 268 ? 6.810   -38.809 -33.255 1.00 29.65  ? 531  TYR   A OH  1 
ATOM   1819 N  N   . ALA   A 1 269 ? 0.049   -39.496 -28.207 1.00 24.18  ? 532  ALA   A N   1 
ATOM   1820 C  CA  . ALA   A 1 269 ? -1.086  -39.429 -27.278 1.00 25.11  ? 532  ALA   A CA  1 
ATOM   1821 C  C   . ALA   A 1 269 ? -0.614  -38.827 -25.980 1.00 29.80  ? 532  ALA   A C   1 
ATOM   1822 O  O   . ALA   A 1 269 ? -0.543  -39.552 -24.965 1.00 30.74  ? 532  ALA   A O   1 
ATOM   1823 C  CB  . ALA   A 1 269 ? -1.666  -40.831 -27.095 1.00 25.75  ? 532  ALA   A CB  1 
ATOM   1824 N  N   . ASP   A 1 270 ? -0.253  -37.560 -25.996 1.00 25.36  ? 533  ASP   A N   1 
ATOM   1825 C  CA  . ASP   A 1 270 ? 0.334   -36.937 -24.795 1.00 27.60  ? 533  ASP   A CA  1 
ATOM   1826 C  C   . ASP   A 1 270 ? -0.831  -36.478 -23.925 1.00 30.27  ? 533  ASP   A C   1 
ATOM   1827 O  O   . ASP   A 1 270 ? -1.681  -35.777 -24.427 1.00 28.37  ? 533  ASP   A O   1 
ATOM   1828 C  CB  . ASP   A 1 270 ? 1.232   -35.755 -25.186 1.00 31.27  ? 533  ASP   A CB  1 
ATOM   1829 C  CG  . ASP   A 1 270 ? 2.531   -36.149 -25.884 1.00 33.07  ? 533  ASP   A CG  1 
ATOM   1830 O  OD1 . ASP   A 1 270 ? 2.885   -37.334 -25.833 1.00 33.52  ? 533  ASP   A OD1 1 
ATOM   1831 O  OD2 . ASP   A 1 270 ? 3.127   -35.294 -26.523 1.00 33.74  ? 533  ASP   A OD2 1 
ATOM   1832 N  N   . ASP   A 1 271 ? -0.827  -36.804 -22.658 1.00 30.87  ? 534  ASP   A N   1 
ATOM   1833 C  CA  . ASP   A 1 271 ? -1.801  -36.270 -21.673 1.00 34.08  ? 534  ASP   A CA  1 
ATOM   1834 C  C   . ASP   A 1 271 ? -1.287  -34.927 -21.156 1.00 34.08  ? 534  ASP   A C   1 
ATOM   1835 O  O   . ASP   A 1 271 ? -0.066  -34.739 -21.056 1.00 32.58  ? 534  ASP   A O   1 
ATOM   1836 C  CB  . ASP   A 1 271 ? -2.017  -37.289 -20.552 1.00 39.87  ? 534  ASP   A CB  1 
ATOM   1837 C  CG  . ASP   A 1 271 ? -3.023  -38.361 -20.930 1.00 47.07  ? 534  ASP   A CG  1 
ATOM   1838 O  OD1 . ASP   A 1 271 ? -3.783  -38.157 -21.932 1.00 45.63  ? 534  ASP   A OD1 1 
ATOM   1839 O  OD2 . ASP   A 1 271 ? -3.085  -39.377 -20.229 1.00 45.74  ? 534  ASP   A OD2 1 
ATOM   1840 N  N   . THR   A 1 272 ? -2.184  -33.972 -20.939 1.00 31.80  ? 535  THR   A N   1 
ATOM   1841 C  CA  . THR   A 1 272 ? -1.870  -32.696 -20.271 1.00 29.57  ? 535  THR   A CA  1 
ATOM   1842 C  C   . THR   A 1 272 ? -1.955  -32.916 -18.765 1.00 30.62  ? 535  THR   A C   1 
ATOM   1843 O  O   . THR   A 1 272 ? -2.861  -33.581 -18.307 1.00 31.41  ? 535  THR   A O   1 
ATOM   1844 C  CB  . THR   A 1 272 ? -2.790  -31.575 -20.750 1.00 33.13  ? 535  THR   A CB  1 
ATOM   1845 O  OG1 . THR   A 1 272 ? -2.608  -31.500 -22.162 1.00 30.91  ? 535  THR   A OG1 1 
ATOM   1846 C  CG2 . THR   A 1 272 ? -2.472  -30.235 -20.132 1.00 30.91  ? 535  THR   A CG2 1 
ATOM   1847 N  N   . ALA   A 1 273 ? -1.041  -32.315 -18.016 1.00 35.97  ? 536  ALA   A N   1 
ATOM   1848 C  CA  . ALA   A 1 273 ? -1.119  -32.235 -16.541 1.00 35.68  ? 536  ALA   A CA  1 
ATOM   1849 C  C   . ALA   A 1 273 ? -2.199  -31.207 -16.137 1.00 34.57  ? 536  ALA   A C   1 
ATOM   1850 O  O   . ALA   A 1 273 ? -1.996  -30.004 -16.350 1.00 39.60  ? 536  ALA   A O   1 
ATOM   1851 C  CB  . ALA   A 1 273 ? 0.271   -31.913 -16.019 1.00 39.76  ? 536  ALA   A CB  1 
ATOM   1852 N  N   . GLY   A 1 274 ? -3.339  -31.676 -15.637 1.00 34.10  ? 537  GLY   A N   1 
ATOM   1853 C  CA  . GLY   A 1 274 ? -4.415  -30.838 -15.063 1.00 38.22  ? 537  GLY   A CA  1 
ATOM   1854 C  C   . GLY   A 1 274 ? -4.983  -29.848 -16.078 1.00 37.49  ? 537  GLY   A C   1 
ATOM   1855 O  O   . GLY   A 1 274 ? -5.009  -28.611 -15.803 1.00 35.48  ? 537  GLY   A O   1 
ATOM   1856 N  N   . TRP   A 1 275 ? -5.497  -30.362 -17.190 1.00 33.18  ? 538  TRP   A N   1 
ATOM   1857 C  CA  . TRP   A 1 275 ? -5.982  -29.536 -18.328 1.00 32.12  ? 538  TRP   A CA  1 
ATOM   1858 C  C   . TRP   A 1 275 ? -6.878  -28.376 -17.857 1.00 27.84  ? 538  TRP   A C   1 
ATOM   1859 O  O   . TRP   A 1 275 ? -6.658  -27.242 -18.331 1.00 33.00  ? 538  TRP   A O   1 
ATOM   1860 C  CB  . TRP   A 1 275 ? -6.711  -30.419 -19.334 1.00 29.69  ? 538  TRP   A CB  1 
ATOM   1861 C  CG  . TRP   A 1 275 ? -7.345  -29.610 -20.426 1.00 29.49  ? 538  TRP   A CG  1 
ATOM   1862 C  CD1 . TRP   A 1 275 ? -8.578  -29.042 -20.400 1.00 31.24  ? 538  TRP   A CD1 1 
ATOM   1863 C  CD2 . TRP   A 1 275 ? -6.807  -29.344 -21.730 1.00 28.88  ? 538  TRP   A CD2 1 
ATOM   1864 N  NE1 . TRP   A 1 275 ? -8.844  -28.444 -21.599 1.00 30.72  ? 538  TRP   A NE1 1 
ATOM   1865 C  CE2 . TRP   A 1 275 ? -7.769  -28.582 -22.425 1.00 31.75  ? 538  TRP   A CE2 1 
ATOM   1866 C  CE3 . TRP   A 1 275 ? -5.640  -29.703 -22.400 1.00 31.09  ? 538  TRP   A CE3 1 
ATOM   1867 C  CZ2 . TRP   A 1 275 ? -7.572  -28.158 -23.739 1.00 31.22  ? 538  TRP   A CZ2 1 
ATOM   1868 C  CZ3 . TRP   A 1 275 ? -5.425  -29.248 -23.675 1.00 29.64  ? 538  TRP   A CZ3 1 
ATOM   1869 C  CH2 . TRP   A 1 275 ? -6.388  -28.498 -24.341 1.00 34.84  ? 538  TRP   A CH2 1 
ATOM   1870 N  N   . ASP   A 1 276 ? -7.902  -28.651 -17.071 1.00 32.70  ? 539  ASP   A N   1 
ATOM   1871 C  CA  . ASP   A 1 276 ? -8.883  -27.633 -16.602 1.00 35.86  ? 539  ASP   A CA  1 
ATOM   1872 C  C   . ASP   A 1 276 ? -8.162  -26.445 -15.932 1.00 39.09  ? 539  ASP   A C   1 
ATOM   1873 O  O   . ASP   A 1 276 ? -8.591  -25.296 -16.138 1.00 38.31  ? 539  ASP   A O   1 
ATOM   1874 C  CB  . ASP   A 1 276 ? -9.976  -28.278 -15.760 1.00 34.96  ? 539  ASP   A CB  1 
ATOM   1875 C  CG  . ASP   A 1 276 ? -11.009 -29.000 -16.616 1.00 39.72  ? 539  ASP   A CG  1 
ATOM   1876 O  OD1 . ASP   A 1 276 ? -10.897 -28.951 -17.881 1.00 40.30  ? 539  ASP   A OD1 1 
ATOM   1877 O  OD2 . ASP   A 1 276 ? -11.888 -29.628 -16.046 1.00 48.30  ? 539  ASP   A OD2 1 
ATOM   1878 N  N   . THR   A 1 277 ? -7.074  -26.690 -15.191 0.50 38.25  ? 540  THR   A N   1 
ATOM   1879 C  CA  . THR   A 1 277 ? -6.314  -25.622 -14.480 0.50 37.54  ? 540  THR   A CA  1 
ATOM   1880 C  C   . THR   A 1 277 ? -5.494  -24.796 -15.475 0.50 38.03  ? 540  THR   A C   1 
ATOM   1881 O  O   . THR   A 1 277 ? -5.165  -23.654 -15.129 0.50 38.69  ? 540  THR   A O   1 
ATOM   1882 C  CB  . THR   A 1 277 ? -5.402  -26.183 -13.379 0.50 37.28  ? 540  THR   A CB  1 
ATOM   1883 O  OG1 . THR   A 1 277 ? -4.210  -26.697 -13.977 0.50 35.95  ? 540  THR   A OG1 1 
ATOM   1884 C  CG2 . THR   A 1 277 ? -6.090  -27.248 -12.556 0.50 37.15  ? 540  THR   A CG2 1 
ATOM   1885 N  N   . ARG   A 1 278 ? -5.181  -25.344 -16.656 0.50 35.75  ? 541  ARG   A N   1 
ATOM   1886 C  CA  . ARG   A 1 278 ? -4.262  -24.719 -17.646 0.50 37.11  ? 541  ARG   A CA  1 
ATOM   1887 C  C   . ARG   A 1 278 ? -5.026  -23.899 -18.692 0.50 35.90  ? 541  ARG   A C   1 
ATOM   1888 O  O   . ARG   A 1 278 ? -4.367  -23.429 -19.620 0.50 34.48  ? 541  ARG   A O   1 
ATOM   1889 C  CB  . ARG   A 1 278 ? -3.444  -25.786 -18.381 0.50 39.76  ? 541  ARG   A CB  1 
ATOM   1890 C  CG  . ARG   A 1 278 ? -2.678  -26.729 -17.468 0.50 44.11  ? 541  ARG   A CG  1 
ATOM   1891 C  CD  . ARG   A 1 278 ? -1.688  -26.020 -16.570 0.50 47.01  ? 541  ARG   A CD  1 
ATOM   1892 N  NE  . ARG   A 1 278 ? -0.872  -26.995 -15.856 0.50 55.02  ? 541  ARG   A NE  1 
ATOM   1893 C  CZ  . ARG   A 1 278 ? 0.440   -27.126 -15.995 0.50 55.26  ? 541  ARG   A CZ  1 
ATOM   1894 N  NH1 . ARG   A 1 278 ? 1.103   -26.322 -16.809 0.50 57.43  ? 541  ARG   A NH1 1 
ATOM   1895 N  NH2 . ARG   A 1 278 ? 1.087   -28.045 -15.303 0.50 56.72  ? 541  ARG   A NH2 1 
ATOM   1896 N  N   . ILE   A 1 279 ? -6.352  -23.773 -18.573 1.00 35.43  ? 542  ILE   A N   1 
ATOM   1897 C  CA  . ILE   A 1 279 ? -7.170  -22.973 -19.521 1.00 35.84  ? 542  ILE   A CA  1 
ATOM   1898 C  C   . ILE   A 1 279 ? -6.912  -21.505 -19.166 1.00 33.05  ? 542  ILE   A C   1 
ATOM   1899 O  O   . ILE   A 1 279 ? -7.146  -21.134 -18.032 1.00 36.88  ? 542  ILE   A O   1 
ATOM   1900 C  CB  . ILE   A 1 279 ? -8.650  -23.402 -19.437 1.00 35.75  ? 542  ILE   A CB  1 
ATOM   1901 C  CG1 . ILE   A 1 279 ? -8.847  -24.765 -20.122 1.00 34.46  ? 542  ILE   A CG1 1 
ATOM   1902 C  CG2 . ILE   A 1 279 ? -9.603  -22.352 -20.013 1.00 33.99  ? 542  ILE   A CG2 1 
ATOM   1903 C  CD1 . ILE   A 1 279 ? -8.821  -24.700 -21.626 1.00 35.61  ? 542  ILE   A CD1 1 
ATOM   1904 N  N   . THR   A 1 280 ? -6.360  -20.741 -20.096 1.00 37.95  ? 543  THR   A N   1 
ATOM   1905 C  CA  . THR   A 1 280 ? -5.952  -19.338 -19.864 1.00 40.75  ? 543  THR   A CA  1 
ATOM   1906 C  C   . THR   A 1 280 ? -7.107  -18.393 -20.183 1.00 42.65  ? 543  THR   A C   1 
ATOM   1907 O  O   . THR   A 1 280 ? -8.121  -18.821 -20.809 1.00 37.56  ? 543  THR   A O   1 
ATOM   1908 C  CB  . THR   A 1 280 ? -4.747  -18.985 -20.724 1.00 34.96  ? 543  THR   A CB  1 
ATOM   1909 O  OG1 . THR   A 1 280 ? -5.113  -19.075 -22.103 1.00 36.09  ? 543  THR   A OG1 1 
ATOM   1910 C  CG2 . THR   A 1 280 ? -3.571  -19.874 -20.418 1.00 39.78  ? 543  THR   A CG2 1 
ATOM   1911 N  N   . LEU   A 1 281 ? -6.999  -17.142 -19.727 0.50 42.32  ? 544  LEU   A N   1 
ATOM   1912 C  CA  . LEU   A 1 281 ? -8.020  -16.105 -20.020 0.50 42.21  ? 544  LEU   A CA  1 
ATOM   1913 C  C   . LEU   A 1 281 ? -8.113  -15.955 -21.543 0.50 38.59  ? 544  LEU   A C   1 
ATOM   1914 O  O   . LEU   A 1 281 ? -9.226  -15.786 -22.041 0.50 39.34  ? 544  LEU   A O   1 
ATOM   1915 C  CB  . LEU   A 1 281 ? -7.653  -14.790 -19.323 0.50 46.70  ? 544  LEU   A CB  1 
ATOM   1916 C  CG  . LEU   A 1 281 ? -8.662  -13.654 -19.500 0.50 50.05  ? 544  LEU   A CG  1 
ATOM   1917 C  CD1 . LEU   A 1 281 ? -10.042 -14.048 -18.982 0.50 50.46  ? 544  LEU   A CD1 1 
ATOM   1918 C  CD2 . LEU   A 1 281 ? -8.178  -12.382 -18.815 0.50 51.81  ? 544  LEU   A CD2 1 
ATOM   1919 N  N   . GLU   A 1 282 ? -6.992  -16.085 -22.260 0.50 37.17  ? 545  GLU   A N   1 
ATOM   1920 C  CA  . GLU   A 1 282 ? -6.965  -16.030 -23.746 0.50 37.16  ? 545  GLU   A CA  1 
ATOM   1921 C  C   . GLU   A 1 282 ? -7.774  -17.202 -24.324 0.50 36.95  ? 545  GLU   A C   1 
ATOM   1922 O  O   . GLU   A 1 282 ? -8.633  -16.944 -25.191 0.50 33.93  ? 545  GLU   A O   1 
ATOM   1923 C  CB  . GLU   A 1 282 ? -5.530  -16.041 -24.266 0.50 39.94  ? 545  GLU   A CB  1 
ATOM   1924 C  CG  . GLU   A 1 282 ? -5.421  -15.617 -25.719 0.50 42.55  ? 545  GLU   A CG  1 
ATOM   1925 C  CD  . GLU   A 1 282 ? -5.637  -14.132 -25.975 0.50 40.65  ? 545  GLU   A CD  1 
ATOM   1926 O  OE1 . GLU   A 1 282 ? -5.927  -13.389 -25.009 0.50 44.55  ? 545  GLU   A OE1 1 
ATOM   1927 O  OE2 . GLU   A 1 282 ? -5.515  -13.724 -27.140 0.50 39.58  ? 545  GLU   A OE2 1 
ATOM   1928 N  N   . ASP   A 1 283 ? -7.547  -18.435 -23.845 1.00 36.44  ? 546  ASP   A N   1 
ATOM   1929 C  CA  . ASP   A 1 283 ? -8.379  -19.602 -24.262 1.00 35.18  ? 546  ASP   A CA  1 
ATOM   1930 C  C   . ASP   A 1 283 ? -9.882  -19.254 -24.111 1.00 34.13  ? 546  ASP   A C   1 
ATOM   1931 O  O   . ASP   A 1 283 ? -10.634 -19.456 -25.072 1.00 36.58  ? 546  ASP   A O   1 
ATOM   1932 C  CB  . ASP   A 1 283 ? -8.068  -20.851 -23.426 1.00 33.10  ? 546  ASP   A CB  1 
ATOM   1933 C  CG  . ASP   A 1 283 ? -6.685  -21.471 -23.635 1.00 32.78  ? 546  ASP   A CG  1 
ATOM   1934 O  OD1 . ASP   A 1 283 ? -6.175  -21.388 -24.769 1.00 30.80  ? 546  ASP   A OD1 1 
ATOM   1935 O  OD2 . ASP   A 1 283 ? -6.184  -22.125 -22.679 1.00 30.71  ? 546  ASP   A OD2 1 
ATOM   1936 N  N   . LEU   A 1 284 ? -10.309 -18.724 -22.966 1.00 32.92  ? 547  LEU   A N   1 
ATOM   1937 C  CA  . LEU   A 1 284 ? -11.738 -18.350 -22.728 1.00 37.36  ? 547  LEU   A CA  1 
ATOM   1938 C  C   . LEU   A 1 284 ? -12.251 -17.315 -23.744 1.00 36.52  ? 547  LEU   A C   1 
ATOM   1939 O  O   . LEU   A 1 284 ? -13.426 -17.396 -24.121 1.00 40.52  ? 547  LEU   A O   1 
ATOM   1940 C  CB  . LEU   A 1 284 ? -11.914 -17.873 -21.289 1.00 38.37  ? 547  LEU   A CB  1 
ATOM   1941 C  CG  . LEU   A 1 284 ? -11.599 -18.921 -20.229 1.00 38.13  ? 547  LEU   A CG  1 
ATOM   1942 C  CD1 . LEU   A 1 284 ? -11.501 -18.286 -18.865 1.00 47.10  ? 547  LEU   A CD1 1 
ATOM   1943 C  CD2 . LEU   A 1 284 ? -12.650 -20.023 -20.197 1.00 40.83  ? 547  LEU   A CD2 1 
ATOM   1944 N  N   . LYS   A 1 285 ? -11.391 -16.379 -24.161 0.50 37.42  ? 548  LYS   A N   1 
ATOM   1945 C  CA  . LYS   A 1 285 ? -11.704 -15.338 -25.180 0.50 38.50  ? 548  LYS   A CA  1 
ATOM   1946 C  C   . LYS   A 1 285 ? -11.949 -16.020 -26.528 0.50 37.56  ? 548  LYS   A C   1 
ATOM   1947 O  O   . LYS   A 1 285 ? -13.001 -15.760 -27.139 0.50 33.81  ? 548  LYS   A O   1 
ATOM   1948 C  CB  . LYS   A 1 285 ? -10.582 -14.298 -25.272 0.50 40.58  ? 548  LYS   A CB  1 
ATOM   1949 C  CG  . LYS   A 1 285 ? -10.544 -13.314 -24.110 0.50 43.67  ? 548  LYS   A CG  1 
ATOM   1950 C  CD  . LYS   A 1 285 ? -9.397  -12.322 -24.142 0.50 46.60  ? 548  LYS   A CD  1 
ATOM   1951 C  CE  . LYS   A 1 285 ? -9.334  -11.485 -22.879 0.50 48.91  ? 548  LYS   A CE  1 
ATOM   1952 N  NZ  . LYS   A 1 285 ? -8.183  -10.549 -22.883 0.50 52.24  ? 548  LYS   A NZ  1 
ATOM   1953 N  N   . ASN   A 1 286 ? -11.027 -16.884 -26.957 0.50 34.01  ? 549  ASN   A N   1 
ATOM   1954 C  CA  . ASN   A 1 286 ? -11.148 -17.607 -28.248 0.50 32.26  ? 549  ASN   A CA  1 
ATOM   1955 C  C   . ASN   A 1 286 ? -12.410 -18.477 -28.218 0.50 29.70  ? 549  ASN   A C   1 
ATOM   1956 O  O   . ASN   A 1 286 ? -13.118 -18.497 -29.234 0.50 30.08  ? 549  ASN   A O   1 
ATOM   1957 C  CB  . ASN   A 1 286 ? -9.875  -18.391 -28.562 0.50 32.08  ? 549  ASN   A CB  1 
ATOM   1958 C  CG  . ASN   A 1 286 ? -8.695  -17.471 -28.795 0.50 34.59  ? 549  ASN   A CG  1 
ATOM   1959 O  OD1 . ASN   A 1 286 ? -8.760  -16.571 -29.634 0.50 32.94  ? 549  ASN   A OD1 1 
ATOM   1960 N  ND2 . ASN   A 1 286 ? -7.622  -17.679 -28.047 0.50 32.91  ? 549  ASN   A ND2 1 
ATOM   1961 N  N   . GLU   A 1 287 ? -12.700 -19.151 -27.099 1.00 29.73  ? 550  GLU   A N   1 
ATOM   1962 C  CA  . GLU   A 1 287 ? -13.960 -19.943 -26.976 1.00 31.21  ? 550  GLU   A CA  1 
ATOM   1963 C  C   . GLU   A 1 287 ? -15.193 -19.024 -27.175 1.00 33.81  ? 550  GLU   A C   1 
ATOM   1964 O  O   . GLU   A 1 287 ? -16.158 -19.417 -27.900 1.00 31.10  ? 550  GLU   A O   1 
ATOM   1965 C  CB  . GLU   A 1 287 ? -13.939 -20.653 -25.623 1.00 30.00  ? 550  GLU   A CB  1 
ATOM   1966 C  CG  . GLU   A 1 287 ? -12.912 -21.798 -25.631 1.00 29.39  ? 550  GLU   A CG  1 
ATOM   1967 C  CD  . GLU   A 1 287 ? -12.644 -22.377 -24.262 1.00 33.33  ? 550  GLU   A CD  1 
ATOM   1968 O  OE1 . GLU   A 1 287 ? -13.394 -22.003 -23.324 1.00 35.32  ? 550  GLU   A OE1 1 
ATOM   1969 O  OE2 . GLU   A 1 287 ? -11.713 -23.239 -24.137 1.00 37.62  ? 550  GLU   A OE2 1 
ATOM   1970 N  N   . GLU   A 1 288 ? -15.140 -17.818 -26.597 0.50 34.82  ? 551  GLU   A N   1 
ATOM   1971 C  CA  . GLU   A 1 288 ? -16.227 -16.796 -26.637 0.50 36.52  ? 551  GLU   A CA  1 
ATOM   1972 C  C   . GLU   A 1 288 ? -16.590 -16.429 -28.082 0.50 36.77  ? 551  GLU   A C   1 
ATOM   1973 O  O   . GLU   A 1 288 ? -17.764 -16.055 -28.314 0.50 39.23  ? 551  GLU   A O   1 
ATOM   1974 C  CB  . GLU   A 1 288 ? -15.799 -15.546 -25.867 0.50 39.75  ? 551  GLU   A CB  1 
ATOM   1975 C  CG  . GLU   A 1 288 ? -16.955 -14.640 -25.471 0.50 42.17  ? 551  GLU   A CG  1 
ATOM   1976 C  CD  . GLU   A 1 288 ? -17.219 -13.474 -26.411 0.50 45.61  ? 551  GLU   A CD  1 
ATOM   1977 O  OE1 . GLU   A 1 288 ? -16.447 -13.314 -27.381 0.50 45.42  ? 551  GLU   A OE1 1 
ATOM   1978 O  OE2 . GLU   A 1 288 ? -18.198 -12.723 -26.164 0.50 46.32  ? 551  GLU   A OE2 1 
ATOM   1979 N  N   . MET   A 1 289 ? -15.643 -16.546 -29.021 0.50 35.80  ? 552  MET   A N   1 
ATOM   1980 C  CA  . MET   A 1 289 ? -15.835 -16.179 -30.451 0.50 36.58  ? 552  MET   A CA  1 
ATOM   1981 C  C   . MET   A 1 289 ? -17.001 -16.965 -31.069 0.50 36.68  ? 552  MET   A C   1 
ATOM   1982 O  O   . MET   A 1 289 ? -17.504 -16.525 -32.130 0.50 35.74  ? 552  MET   A O   1 
ATOM   1983 C  CB  . MET   A 1 289 ? -14.570 -16.422 -31.284 0.50 38.02  ? 552  MET   A CB  1 
ATOM   1984 C  CG  . MET   A 1 289 ? -13.480 -15.378 -31.066 0.50 41.25  ? 552  MET   A CG  1 
ATOM   1985 S  SD  . MET   A 1 289 ? -12.328 -15.222 -32.475 0.50 45.75  ? 552  MET   A SD  1 
ATOM   1986 C  CE  . MET   A 1 289 ? -11.862 -16.931 -32.720 0.50 44.73  ? 552  MET   A CE  1 
ATOM   1987 N  N   . VAL   A 1 290 ? -17.432 -18.080 -30.466 1.00 34.47  ? 553  VAL   A N   1 
ATOM   1988 C  CA  . VAL   A 1 290 ? -18.636 -18.798 -30.974 1.00 34.28  ? 553  VAL   A CA  1 
ATOM   1989 C  C   . VAL   A 1 290 ? -19.822 -17.792 -31.050 1.00 30.75  ? 553  VAL   A C   1 
ATOM   1990 O  O   . VAL   A 1 290 ? -20.645 -17.954 -31.970 1.00 38.30  ? 553  VAL   A O   1 
ATOM   1991 C  CB  . VAL   A 1 290 ? -19.005 -20.070 -30.194 1.00 29.32  ? 553  VAL   A CB  1 
ATOM   1992 C  CG1 . VAL   A 1 290 ? -19.433 -19.808 -28.763 1.00 30.42  ? 553  VAL   A CG1 1 
ATOM   1993 C  CG2 . VAL   A 1 290 ? -20.085 -20.839 -30.920 1.00 29.79  ? 553  VAL   A CG2 1 
ATOM   1994 N  N   . THR   A 1 291 ? -19.915 -16.818 -30.136 1.00 31.88  ? 554  THR   A N   1 
ATOM   1995 C  CA  . THR   A 1 291 ? -20.996 -15.769 -30.093 1.00 34.32  ? 554  THR   A CA  1 
ATOM   1996 C  C   . THR   A 1 291 ? -21.027 -14.933 -31.388 1.00 35.82  ? 554  THR   A C   1 
ATOM   1997 O  O   . THR   A 1 291 ? -22.109 -14.342 -31.690 1.00 39.77  ? 554  THR   A O   1 
ATOM   1998 C  CB  . THR   A 1 291 ? -20.857 -14.790 -28.922 1.00 33.60  ? 554  THR   A CB  1 
ATOM   1999 O  OG1 . THR   A 1 291 ? -19.577 -14.159 -29.057 1.00 34.27  ? 554  THR   A OG1 1 
ATOM   2000 C  CG2 . THR   A 1 291 ? -20.986 -15.427 -27.558 1.00 34.35  ? 554  THR   A CG2 1 
ATOM   2001 N  N   . ASN   A 1 292 ? -19.909 -14.818 -32.101 1.00 38.12  ? 555  ASN   A N   1 
ATOM   2002 C  CA  . ASN   A 1 292 ? -19.821 -14.068 -33.387 1.00 42.42  ? 555  ASN   A CA  1 
ATOM   2003 C  C   . ASN   A 1 292 ? -20.749 -14.687 -34.427 1.00 47.09  ? 555  ASN   A C   1 
ATOM   2004 O  O   . ASN   A 1 292 ? -20.925 -14.068 -35.467 1.00 45.58  ? 555  ASN   A O   1 
ATOM   2005 C  CB  . ASN   A 1 292 ? -18.430 -14.050 -34.013 1.00 39.49  ? 555  ASN   A CB  1 
ATOM   2006 C  CG  . ASN   A 1 292 ? -17.424 -13.309 -33.161 1.00 41.08  ? 555  ASN   A CG  1 
ATOM   2007 O  OD1 . ASN   A 1 292 ? -17.779 -12.659 -32.180 1.00 44.95  ? 555  ASN   A OD1 1 
ATOM   2008 N  ND2 . ASN   A 1 292 ? -16.160 -13.434 -33.507 1.00 41.26  ? 555  ASN   A ND2 1 
ATOM   2009 N  N   . HIS   A 1 293 ? -21.224 -15.911 -34.192 1.00 41.67  ? 556  HIS   A N   1 
ATOM   2010 C  CA  . HIS   A 1 293 ? -22.031 -16.712 -35.143 1.00 47.56  ? 556  HIS   A CA  1 
ATOM   2011 C  C   . HIS   A 1 293 ? -23.506 -16.677 -34.730 1.00 39.37  ? 556  HIS   A C   1 
ATOM   2012 O  O   . HIS   A 1 293 ? -24.308 -17.427 -35.332 1.00 38.09  ? 556  HIS   A O   1 
ATOM   2013 C  CB  . HIS   A 1 293 ? -21.439 -18.139 -35.208 1.00 46.18  ? 556  HIS   A CB  1 
ATOM   2014 C  CG  . HIS   A 1 293 ? -20.060 -18.151 -35.781 1.00 49.88  ? 556  HIS   A CG  1 
ATOM   2015 N  ND1 . HIS   A 1 293 ? -19.832 -18.300 -37.142 1.00 50.63  ? 556  HIS   A ND1 1 
ATOM   2016 C  CD2 . HIS   A 1 293 ? -18.842 -17.990 -35.200 1.00 48.72  ? 556  HIS   A CD2 1 
ATOM   2017 C  CE1 . HIS   A 1 293 ? -18.533 -18.236 -37.374 1.00 47.44  ? 556  HIS   A CE1 1 
ATOM   2018 N  NE2 . HIS   A 1 293 ? -17.904 -18.030 -36.201 1.00 43.64  ? 556  HIS   A NE2 1 
ATOM   2019 N  N   . MET   A 1 294 ? -23.823 -15.957 -33.657 1.00 33.63  ? 557  MET   A N   1 
ATOM   2020 C  CA  . MET   A 1 294 ? -25.184 -15.907 -33.081 1.00 36.72  ? 557  MET   A CA  1 
ATOM   2021 C  C   . MET   A 1 294 ? -25.862 -14.567 -33.432 1.00 42.80  ? 557  MET   A C   1 
ATOM   2022 O  O   . MET   A 1 294 ? -25.210 -13.731 -34.008 1.00 38.34  ? 557  MET   A O   1 
ATOM   2023 C  CB  . MET   A 1 294 ? -25.126 -16.081 -31.566 1.00 37.29  ? 557  MET   A CB  1 
ATOM   2024 C  CG  . MET   A 1 294 ? -24.491 -17.414 -31.112 1.00 33.74  ? 557  MET   A CG  1 
ATOM   2025 S  SD  . MET   A 1 294 ? -24.340 -17.345 -29.357 1.00 33.59  ? 557  MET   A SD  1 
ATOM   2026 C  CE  . MET   A 1 294 ? -23.428 -18.873 -29.051 1.00 38.18  ? 557  MET   A CE  1 
ATOM   2027 N  N   . GLU   A 1 295 ? -27.134 -14.396 -33.067 1.00 48.28  ? 558  GLU   A N   1 
ATOM   2028 C  CA  . GLU   A 1 295 ? -27.897 -13.131 -33.283 1.00 48.52  ? 558  GLU   A CA  1 
ATOM   2029 C  C   . GLU   A 1 295 ? -28.976 -12.980 -32.209 1.00 48.59  ? 558  GLU   A C   1 
ATOM   2030 O  O   . GLU   A 1 295 ? -29.305 -13.989 -31.546 1.00 43.20  ? 558  GLU   A O   1 
ATOM   2031 C  CB  . GLU   A 1 295 ? -28.503 -13.153 -34.687 1.00 48.07  ? 558  GLU   A CB  1 
ATOM   2032 C  CG  . GLU   A 1 295 ? -29.579 -14.183 -34.895 1.00 48.37  ? 558  GLU   A CG  1 
ATOM   2033 C  CD  . GLU   A 1 295 ? -30.057 -14.351 -36.334 1.00 65.56  ? 558  GLU   A CD  1 
ATOM   2034 O  OE1 . GLU   A 1 295 ? -29.207 -14.395 -37.284 1.00 70.95  ? 558  GLU   A OE1 1 
ATOM   2035 O  OE2 . GLU   A 1 295 ? -31.287 -14.460 -36.514 1.00 63.70  ? 558  GLU   A OE2 1 
ATOM   2036 N  N   . GLY   A 1 296 ? -29.578 -11.786 -32.112 1.00 51.93  ? 559  GLY   A N   1 
ATOM   2037 C  CA  . GLY   A 1 296 ? -30.741 -11.510 -31.249 1.00 48.47  ? 559  GLY   A CA  1 
ATOM   2038 C  C   . GLY   A 1 296 ? -30.436 -11.762 -29.783 1.00 47.96  ? 559  GLY   A C   1 
ATOM   2039 O  O   . GLY   A 1 296 ? -29.256 -11.559 -29.381 1.00 54.82  ? 559  GLY   A O   1 
ATOM   2040 N  N   . GLU   A 1 297 ? -31.456 -12.228 -29.048 1.00 45.45  ? 560  GLU   A N   1 
ATOM   2041 C  CA  . GLU   A 1 297 ? -31.432 -12.580 -27.607 1.00 49.62  ? 560  GLU   A CA  1 
ATOM   2042 C  C   . GLU   A 1 297 ? -30.292 -13.587 -27.363 1.00 52.99  ? 560  GLU   A C   1 
ATOM   2043 O  O   . GLU   A 1 297 ? -29.459 -13.354 -26.471 1.00 50.81  ? 560  GLU   A O   1 
ATOM   2044 C  CB  . GLU   A 1 297 ? -32.752 -13.238 -27.203 1.00 52.59  ? 560  GLU   A CB  1 
ATOM   2045 C  CG  . GLU   A 1 297 ? -33.410 -12.625 -25.987 1.00 63.85  ? 560  GLU   A CG  1 
ATOM   2046 C  CD  . GLU   A 1 297 ? -34.792 -13.181 -25.685 1.00 72.97  ? 560  GLU   A CD  1 
ATOM   2047 O  OE1 . GLU   A 1 297 ? -34.913 -14.423 -25.625 1.00 67.53  ? 560  GLU   A OE1 1 
ATOM   2048 O  OE2 . GLU   A 1 297 ? -35.743 -12.372 -25.515 1.00 81.48  ? 560  GLU   A OE2 1 
ATOM   2049 N  N   . HIS   A 1 298 ? -30.268 -14.665 -28.144 1.00 48.06  ? 561  HIS   A N   1 
ATOM   2050 C  CA  . HIS   A 1 298 ? -29.273 -15.767 -28.014 1.00 46.22  ? 561  HIS   A CA  1 
ATOM   2051 C  C   . HIS   A 1 298 ? -27.870 -15.178 -27.874 1.00 41.62  ? 561  HIS   A C   1 
ATOM   2052 O  O   . HIS   A 1 298 ? -27.208 -15.493 -26.885 1.00 48.78  ? 561  HIS   A O   1 
ATOM   2053 C  CB  . HIS   A 1 298 ? -29.336 -16.735 -29.195 1.00 43.46  ? 561  HIS   A CB  1 
ATOM   2054 C  CG  . HIS   A 1 298 ? -28.443 -17.908 -28.982 1.00 43.73  ? 561  HIS   A CG  1 
ATOM   2055 N  ND1 . HIS   A 1 298 ? -27.946 -18.667 -30.032 1.00 39.06  ? 561  HIS   A ND1 1 
ATOM   2056 C  CD2 . HIS   A 1 298 ? -27.930 -18.414 -27.834 1.00 39.90  ? 561  HIS   A CD2 1 
ATOM   2057 C  CE1 . HIS   A 1 298 ? -27.181 -19.614 -29.530 1.00 38.67  ? 561  HIS   A CE1 1 
ATOM   2058 N  NE2 . HIS   A 1 298 ? -27.170 -19.492 -28.176 1.00 39.77  ? 561  HIS   A NE2 1 
ATOM   2059 N  N   . LYS   A 1 299 ? -27.458 -14.318 -28.805 1.00 41.61  ? 562  LYS   A N   1 
ATOM   2060 C  CA  . LYS   A 1 299 ? -26.119 -13.694 -28.812 1.00 42.93  ? 562  LYS   A CA  1 
ATOM   2061 C  C   . LYS   A 1 299 ? -25.863 -13.012 -27.473 1.00 53.52  ? 562  LYS   A C   1 
ATOM   2062 O  O   . LYS   A 1 299 ? -24.709 -13.109 -26.976 1.00 50.61  ? 562  LYS   A O   1 
ATOM   2063 C  CB  . LYS   A 1 299 ? -25.923 -12.717 -29.963 1.00 44.19  ? 562  LYS   A CB  1 
ATOM   2064 C  CG  . LYS   A 1 299 ? -24.552 -12.050 -30.000 1.00 45.31  ? 562  LYS   A CG  1 
ATOM   2065 C  CD  . LYS   A 1 299 ? -24.366 -11.275 -31.272 1.00 48.21  ? 562  LYS   A CD  1 
ATOM   2066 C  CE  . LYS   A 1 299 ? -23.215 -10.295 -31.301 1.00 48.11  ? 562  LYS   A CE  1 
ATOM   2067 N  NZ  . LYS   A 1 299 ? -22.133 -10.775 -32.185 1.00 53.07  ? 562  LYS   A NZ  1 
ATOM   2068 N  N   . LYS   A 1 300 ? -26.872 -12.347 -26.910 1.00 51.74  ? 563  LYS   A N   1 
ATOM   2069 C  CA  . LYS   A 1 300 ? -26.682 -11.532 -25.681 1.00 56.20  ? 563  LYS   A CA  1 
ATOM   2070 C  C   . LYS   A 1 300 ? -26.637 -12.472 -24.490 1.00 44.70  ? 563  LYS   A C   1 
ATOM   2071 O  O   . LYS   A 1 300 ? -25.796 -12.283 -23.636 1.00 46.54  ? 563  LYS   A O   1 
ATOM   2072 C  CB  . LYS   A 1 300 ? -27.802 -10.497 -25.497 1.00 64.88  ? 563  LYS   A CB  1 
ATOM   2073 C  CG  . LYS   A 1 300 ? -27.744 -9.332  -26.479 1.00 74.91  ? 563  LYS   A CG  1 
ATOM   2074 C  CD  . LYS   A 1 300 ? -26.541 -8.406  -26.315 1.00 74.38  ? 563  LYS   A CD  1 
ATOM   2075 C  CE  . LYS   A 1 300 ? -25.943 -7.957  -27.635 1.00 78.58  ? 563  LYS   A CE  1 
ATOM   2076 N  NZ  . LYS   A 1 300 ? -25.373 -6.589  -27.543 1.00 85.60  ? 563  LYS   A NZ  1 
ATOM   2077 N  N   . LEU   A 1 301 ? -27.499 -13.487 -24.481 1.00 43.28  ? 564  LEU   A N   1 
ATOM   2078 C  CA  . LEU   A 1 301 ? -27.522 -14.476 -23.386 1.00 44.33  ? 564  LEU   A CA  1 
ATOM   2079 C  C   . LEU   A 1 301 ? -26.185 -15.263 -23.353 1.00 48.45  ? 564  LEU   A C   1 
ATOM   2080 O  O   . LEU   A 1 301 ? -25.694 -15.509 -22.237 1.00 40.94  ? 564  LEU   A O   1 
ATOM   2081 C  CB  . LEU   A 1 301 ? -28.742 -15.374 -23.573 1.00 48.73  ? 564  LEU   A CB  1 
ATOM   2082 C  CG  . LEU   A 1 301 ? -30.098 -14.708 -23.286 1.00 47.13  ? 564  LEU   A CG  1 
ATOM   2083 C  CD1 . LEU   A 1 301 ? -31.217 -15.643 -23.684 1.00 48.90  ? 564  LEU   A CD1 1 
ATOM   2084 C  CD2 . LEU   A 1 301 ? -30.221 -14.330 -21.817 1.00 46.89  ? 564  LEU   A CD2 1 
ATOM   2085 N  N   . ALA   A 1 302 ? -25.598 -15.592 -24.513 1.00 42.65  ? 565  ALA   A N   1 
ATOM   2086 C  CA  . ALA   A 1 302 ? -24.316 -16.342 -24.631 1.00 45.11  ? 565  ALA   A CA  1 
ATOM   2087 C  C   . ALA   A 1 302 ? -23.151 -15.447 -24.191 1.00 42.27  ? 565  ALA   A C   1 
ATOM   2088 O  O   . ALA   A 1 302 ? -22.255 -15.945 -23.483 1.00 39.65  ? 565  ALA   A O   1 
ATOM   2089 C  CB  . ALA   A 1 302 ? -24.118 -16.842 -26.044 1.00 43.64  ? 565  ALA   A CB  1 
ATOM   2090 N  N   . GLU   A 1 303 ? -23.144 -14.179 -24.612 1.00 42.08  ? 566  GLU   A N   1 
ATOM   2091 C  CA  . GLU   A 1 303 ? -22.072 -13.203 -24.260 1.00 43.94  ? 566  GLU   A CA  1 
ATOM   2092 C  C   . GLU   A 1 303 ? -22.018 -13.021 -22.737 1.00 43.41  ? 566  GLU   A C   1 
ATOM   2093 O  O   . GLU   A 1 303 ? -20.898 -12.869 -22.198 1.00 42.98  ? 566  GLU   A O   1 
ATOM   2094 C  CB  . GLU   A 1 303 ? -22.286 -11.882 -24.985 1.00 52.14  ? 566  GLU   A CB  1 
ATOM   2095 C  CG  . GLU   A 1 303 ? -21.867 -11.936 -26.432 1.00 55.97  ? 566  GLU   A CG  1 
ATOM   2096 C  CD  . GLU   A 1 303 ? -22.260 -10.688 -27.206 1.00 63.41  ? 566  GLU   A CD  1 
ATOM   2097 O  OE1 . GLU   A 1 303 ? -22.859 -9.796  -26.587 1.00 63.02  ? 566  GLU   A OE1 1 
ATOM   2098 O  OE2 . GLU   A 1 303 ? -21.973 -10.618 -28.430 1.00 53.51  ? 566  GLU   A OE2 1 
ATOM   2099 N  N   . ALA   A 1 304 ? -23.164 -13.131 -22.065 1.00 41.37  ? 567  ALA   A N   1 
ATOM   2100 C  CA  . ALA   A 1 304 ? -23.305 -12.963 -20.599 1.00 44.30  ? 567  ALA   A CA  1 
ATOM   2101 C  C   . ALA   A 1 304 ? -22.774 -14.205 -19.885 1.00 42.78  ? 567  ALA   A C   1 
ATOM   2102 O  O   . ALA   A 1 304 ? -22.088 -14.021 -18.877 1.00 40.17  ? 567  ALA   A O   1 
ATOM   2103 C  CB  . ALA   A 1 304 ? -24.743 -12.707 -20.205 1.00 46.52  ? 567  ALA   A CB  1 
ATOM   2104 N  N   . ILE   A 1 305 ? -23.133 -15.407 -20.347 1.00 41.18  ? 568  ILE   A N   1 
ATOM   2105 C  CA  . ILE   A 1 305 ? -22.542 -16.653 -19.783 1.00 42.34  ? 568  ILE   A CA  1 
ATOM   2106 C  C   . ILE   A 1 305 ? -21.006 -16.532 -19.828 1.00 37.03  ? 568  ILE   A C   1 
ATOM   2107 O  O   . ILE   A 1 305 ? -20.395 -16.687 -18.760 1.00 37.93  ? 568  ILE   A O   1 
ATOM   2108 C  CB  . ILE   A 1 305 ? -23.071 -17.927 -20.469 1.00 44.36  ? 568  ILE   A CB  1 
ATOM   2109 C  CG1 . ILE   A 1 305 ? -24.568 -18.139 -20.211 1.00 43.58  ? 568  ILE   A CG1 1 
ATOM   2110 C  CG2 . ILE   A 1 305 ? -22.256 -19.150 -20.040 1.00 44.11  ? 568  ILE   A CG2 1 
ATOM   2111 C  CD1 . ILE   A 1 305 ? -24.937 -18.251 -18.743 1.00 42.90  ? 568  ILE   A CD1 1 
ATOM   2112 N  N   . PHE   A 1 306 ? -20.392 -16.234 -20.977 1.00 36.84  ? 569  PHE   A N   1 
ATOM   2113 C  CA  . PHE   A 1 306 ? -18.912 -16.173 -21.126 1.00 37.12  ? 569  PHE   A CA  1 
ATOM   2114 C  C   . PHE   A 1 306 ? -18.327 -15.064 -20.235 1.00 46.49  ? 569  PHE   A C   1 
ATOM   2115 O  O   . PHE   A 1 306 ? -17.394 -15.372 -19.491 1.00 42.61  ? 569  PHE   A O   1 
ATOM   2116 C  CB  . PHE   A 1 306 ? -18.478 -15.983 -22.584 1.00 41.98  ? 569  PHE   A CB  1 
ATOM   2117 C  CG  . PHE   A 1 306 ? -18.501 -17.241 -23.421 1.00 42.58  ? 569  PHE   A CG  1 
ATOM   2118 C  CD1 . PHE   A 1 306 ? -17.493 -18.186 -23.305 1.00 42.86  ? 569  PHE   A CD1 1 
ATOM   2119 C  CD2 . PHE   A 1 306 ? -19.476 -17.445 -24.382 1.00 40.21  ? 569  PHE   A CD2 1 
ATOM   2120 C  CE1 . PHE   A 1 306 ? -17.498 -19.332 -24.082 1.00 40.86  ? 569  PHE   A CE1 1 
ATOM   2121 C  CE2 . PHE   A 1 306 ? -19.479 -18.587 -25.173 1.00 39.72  ? 569  PHE   A CE2 1 
ATOM   2122 C  CZ  . PHE   A 1 306 ? -18.506 -19.541 -24.997 1.00 40.83  ? 569  PHE   A CZ  1 
ATOM   2123 N  N   . LYS   A 1 307 ? -18.828 -13.820 -20.323 1.00 46.77  ? 570  LYS   A N   1 
ATOM   2124 C  CA  . LYS   A 1 307 ? -18.327 -12.629 -19.570 1.00 50.13  ? 570  LYS   A CA  1 
ATOM   2125 C  C   . LYS   A 1 307 ? -18.527 -12.800 -18.058 1.00 45.05  ? 570  LYS   A C   1 
ATOM   2126 O  O   . LYS   A 1 307 ? -17.577 -12.563 -17.289 1.00 45.56  ? 570  LYS   A O   1 
ATOM   2127 C  CB  . LYS   A 1 307 ? -19.092 -11.348 -19.940 1.00 63.86  ? 570  LYS   A CB  1 
ATOM   2128 C  CG  . LYS   A 1 307 ? -18.402 -10.380 -20.889 1.00 76.41  ? 570  LYS   A CG  1 
ATOM   2129 C  CD  . LYS   A 1 307 ? -18.873 -8.939  -20.686 1.00 91.35  ? 570  LYS   A CD  1 
ATOM   2130 C  CE  . LYS   A 1 307 ? -18.221 -7.934  -21.616 1.00 97.08  ? 570  LYS   A CE  1 
ATOM   2131 N  NZ  . LYS   A 1 307 ? -18.305 -8.363  -23.032 1.00 108.27 ? 570  LYS   A NZ  1 
ATOM   2132 N  N   . LEU   A 1 308 ? -19.733 -13.159 -17.630 1.00 43.89  ? 571  LEU   A N   1 
ATOM   2133 C  CA  . LEU   A 1 308 ? -20.132 -13.020 -16.206 1.00 44.08  ? 571  LEU   A CA  1 
ATOM   2134 C  C   . LEU   A 1 308 ? -19.820 -14.281 -15.414 1.00 47.89  ? 571  LEU   A C   1 
ATOM   2135 O  O   . LEU   A 1 308 ? -19.610 -14.135 -14.193 1.00 49.56  ? 571  LEU   A O   1 
ATOM   2136 C  CB  . LEU   A 1 308 ? -21.629 -12.688 -16.135 1.00 48.20  ? 571  LEU   A CB  1 
ATOM   2137 C  CG  . LEU   A 1 308 ? -22.025 -11.416 -16.894 1.00 54.11  ? 571  LEU   A CG  1 
ATOM   2138 C  CD1 . LEU   A 1 308 ? -23.529 -11.192 -16.855 1.00 56.59  ? 571  LEU   A CD1 1 
ATOM   2139 C  CD2 . LEU   A 1 308 ? -21.288 -10.210 -16.336 1.00 49.06  ? 571  LEU   A CD2 1 
ATOM   2140 N  N   . THR   A 1 309 ? -19.862 -15.477 -16.024 1.00 43.63  ? 572  THR   A N   1 
ATOM   2141 C  CA  . THR   A 1 309 ? -19.727 -16.745 -15.267 1.00 43.20  ? 572  THR   A CA  1 
ATOM   2142 C  C   . THR   A 1 309 ? -18.453 -17.518 -15.641 1.00 43.48  ? 572  THR   A C   1 
ATOM   2143 O  O   . THR   A 1 309 ? -18.022 -18.265 -14.820 1.00 41.27  ? 572  THR   A O   1 
ATOM   2144 C  CB  . THR   A 1 309 ? -20.947 -17.657 -15.415 1.00 49.73  ? 572  THR   A CB  1 
ATOM   2145 O  OG1 . THR   A 1 309 ? -20.984 -18.106 -16.771 1.00 49.49  ? 572  THR   A OG1 1 
ATOM   2146 C  CG2 . THR   A 1 309 ? -22.235 -16.963 -15.038 1.00 51.77  ? 572  THR   A CG2 1 
ATOM   2147 N  N   . TYR   A 1 310 ? -17.877 -17.360 -16.825 1.00 43.93  ? 573  TYR   A N   1 
ATOM   2148 C  CA  . TYR   A 1 310 ? -16.688 -18.160 -17.229 1.00 47.98  ? 573  TYR   A CA  1 
ATOM   2149 C  C   . TYR   A 1 310 ? -15.439 -17.313 -17.036 1.00 47.96  ? 573  TYR   A C   1 
ATOM   2150 O  O   . TYR   A 1 310 ? -14.494 -17.836 -16.438 1.00 50.70  ? 573  TYR   A O   1 
ATOM   2151 C  CB  . TYR   A 1 310 ? -16.769 -18.669 -18.675 1.00 40.95  ? 573  TYR   A CB  1 
ATOM   2152 C  CG  . TYR   A 1 310 ? -17.808 -19.725 -18.942 1.00 37.29  ? 573  TYR   A CG  1 
ATOM   2153 C  CD1 . TYR   A 1 310 ? -18.592 -20.262 -17.943 1.00 37.36  ? 573  TYR   A CD1 1 
ATOM   2154 C  CD2 . TYR   A 1 310 ? -18.011 -20.187 -20.231 1.00 39.82  ? 573  TYR   A CD2 1 
ATOM   2155 C  CE1 . TYR   A 1 310 ? -19.550 -21.226 -18.211 1.00 39.35  ? 573  TYR   A CE1 1 
ATOM   2156 C  CE2 . TYR   A 1 310 ? -18.970 -21.142 -20.518 1.00 35.47  ? 573  TYR   A CE2 1 
ATOM   2157 C  CZ  . TYR   A 1 310 ? -19.733 -21.671 -19.509 1.00 38.07  ? 573  TYR   A CZ  1 
ATOM   2158 O  OH  . TYR   A 1 310 ? -20.677 -22.597 -19.816 1.00 40.82  ? 573  TYR   A OH  1 
ATOM   2159 N  N   . GLN   A 1 311 ? -15.439 -16.079 -17.553 1.00 42.33  ? 574  GLN   A N   1 
ATOM   2160 C  CA  . GLN   A 1 311 ? -14.270 -15.173 -17.493 1.00 42.59  ? 574  GLN   A CA  1 
ATOM   2161 C  C   . GLN   A 1 311 ? -14.208 -14.389 -16.166 1.00 46.23  ? 574  GLN   A C   1 
ATOM   2162 O  O   . GLN   A 1 311 ? -13.222 -13.687 -15.948 1.00 44.60  ? 574  GLN   A O   1 
ATOM   2163 C  CB  . GLN   A 1 311 ? -14.257 -14.261 -18.700 1.00 42.28  ? 574  GLN   A CB  1 
ATOM   2164 C  CG  . GLN   A 1 311 ? -14.208 -15.029 -19.999 1.00 43.38  ? 574  GLN   A CG  1 
ATOM   2165 C  CD  . GLN   A 1 311 ? -14.272 -14.115 -21.191 1.00 44.37  ? 574  GLN   A CD  1 
ATOM   2166 O  OE1 . GLN   A 1 311 ? -14.199 -12.903 -21.079 1.00 56.53  ? 574  GLN   A OE1 1 
ATOM   2167 N  NE2 . GLN   A 1 311 ? -14.380 -14.701 -22.363 1.00 52.20  ? 574  GLN   A NE2 1 
ATOM   2168 N  N   . ASN   A 1 312 ? -15.184 -14.566 -15.260 0.50 48.19  ? 575  ASN   A N   1 
ATOM   2169 C  CA  . ASN   A 1 312 ? -15.224 -13.874 -13.936 0.50 50.83  ? 575  ASN   A CA  1 
ATOM   2170 C  C   . ASN   A 1 312 ? -16.056 -14.681 -12.927 0.50 53.30  ? 575  ASN   A C   1 
ATOM   2171 O  O   . ASN   A 1 312 ? -17.230 -14.321 -12.719 0.50 58.57  ? 575  ASN   A O   1 
ATOM   2172 C  CB  . ASN   A 1 312 ? -15.792 -12.455 -14.060 0.50 51.08  ? 575  ASN   A CB  1 
ATOM   2173 C  CG  . ASN   A 1 312 ? -14.794 -11.442 -14.584 0.50 52.42  ? 575  ASN   A CG  1 
ATOM   2174 O  OD1 . ASN   A 1 312 ? -13.938 -10.970 -13.842 0.50 54.81  ? 575  ASN   A OD1 1 
ATOM   2175 N  ND2 . ASN   A 1 312 ? -14.902 -11.089 -15.856 0.50 52.43  ? 575  ASN   A ND2 1 
ATOM   2176 N  N   . LYS   A 1 313 ? -15.453 -15.680 -12.272 0.50 55.44  ? 576  LYS   A N   1 
ATOM   2177 C  CA  . LYS   A 1 313 ? -16.151 -16.713 -11.453 0.50 57.04  ? 576  LYS   A CA  1 
ATOM   2178 C  C   . LYS   A 1 313 ? -16.286 -16.261 -9.991  0.50 59.39  ? 576  LYS   A C   1 
ATOM   2179 O  O   . LYS   A 1 313 ? -15.487 -15.405 -9.570  0.50 60.21  ? 576  LYS   A O   1 
ATOM   2180 C  CB  . LYS   A 1 313 ? -15.374 -18.033 -11.475 0.50 57.77  ? 576  LYS   A CB  1 
ATOM   2181 C  CG  . LYS   A 1 313 ? -14.720 -18.391 -12.803 0.50 60.21  ? 576  LYS   A CG  1 
ATOM   2182 C  CD  . LYS   A 1 313 ? -13.942 -19.691 -12.755 0.50 59.04  ? 576  LYS   A CD  1 
ATOM   2183 C  CE  . LYS   A 1 313 ? -13.527 -20.183 -14.125 0.50 60.72  ? 576  LYS   A CE  1 
ATOM   2184 N  NZ  . LYS   A 1 313 ? -12.712 -19.179 -14.847 0.50 60.87  ? 576  LYS   A NZ  1 
ATOM   2185 N  N   . VAL   A 1 314 ? -17.257 -16.834 -9.264  1.00 55.23  ? 577  VAL   A N   1 
ATOM   2186 C  CA  . VAL   A 1 314 ? -17.440 -16.652 -7.805  1.00 55.27  ? 577  VAL   A CA  1 
ATOM   2187 C  C   . VAL   A 1 314 ? -17.681 -18.059 -7.276  1.00 48.02  ? 577  VAL   A C   1 
ATOM   2188 O  O   . VAL   A 1 314 ? -18.528 -18.757 -7.809  1.00 43.68  ? 577  VAL   A O   1 
ATOM   2189 C  CB  . VAL   A 1 314 ? -18.613 -15.704 -7.482  1.00 60.07  ? 577  VAL   A CB  1 
ATOM   2190 C  CG1 . VAL   A 1 314 ? -18.954 -15.733 -5.993  1.00 61.77  ? 577  VAL   A CG1 1 
ATOM   2191 C  CG2 . VAL   A 1 314 ? -18.341 -14.286 -7.972  1.00 55.14  ? 577  VAL   A CG2 1 
ATOM   2192 N  N   . VAL   A 1 315 ? -16.928 -18.475 -6.272  1.00 45.75  ? 578  VAL   A N   1 
ATOM   2193 C  CA  . VAL   A 1 315 ? -16.901 -19.898 -5.846  1.00 49.58  ? 578  VAL   A CA  1 
ATOM   2194 C  C   . VAL   A 1 315 ? -17.006 -19.968 -4.323  1.00 48.75  ? 578  VAL   A C   1 
ATOM   2195 O  O   . VAL   A 1 315 ? -16.419 -19.106 -3.660  1.00 52.68  ? 578  VAL   A O   1 
ATOM   2196 C  CB  . VAL   A 1 315 ? -15.604 -20.541 -6.365  1.00 52.51  ? 578  VAL   A CB  1 
ATOM   2197 C  CG1 . VAL   A 1 315 ? -15.526 -22.007 -5.981  1.00 56.27  ? 578  VAL   A CG1 1 
ATOM   2198 C  CG2 . VAL   A 1 315 ? -15.447 -20.356 -7.865  1.00 54.84  ? 578  VAL   A CG2 1 
ATOM   2199 N  N   . ARG   A 1 316 ? -17.677 -20.984 -3.799  1.00 56.61  ? 579  ARG   A N   1 
ATOM   2200 C  CA  . ARG   A 1 316 ? -17.723 -21.227 -2.342  1.00 64.70  ? 579  ARG   A CA  1 
ATOM   2201 C  C   . ARG   A 1 316 ? -17.120 -22.616 -2.048  1.00 72.18  ? 579  ARG   A C   1 
ATOM   2202 O  O   . ARG   A 1 316 ? -17.520 -23.607 -2.682  1.00 77.73  ? 579  ARG   A O   1 
ATOM   2203 C  CB  . ARG   A 1 316 ? -19.139 -20.935 -1.852  1.00 69.06  ? 579  ARG   A CB  1 
ATOM   2204 C  CG  . ARG   A 1 316 ? -20.205 -21.878 -2.369  1.00 74.61  ? 579  ARG   A CG  1 
ATOM   2205 C  CD  . ARG   A 1 316 ? -21.517 -21.587 -1.670  1.00 82.17  ? 579  ARG   A CD  1 
ATOM   2206 N  NE  . ARG   A 1 316 ? -22.119 -20.332 -2.096  1.00 87.28  ? 579  ARG   A NE  1 
ATOM   2207 C  CZ  . ARG   A 1 316 ? -23.356 -19.957 -1.800  1.00 90.71  ? 579  ARG   A CZ  1 
ATOM   2208 N  NH1 . ARG   A 1 316 ? -23.816 -18.795 -2.234  1.00 89.93  ? 579  ARG   A NH1 1 
ATOM   2209 N  NH2 . ARG   A 1 316 ? -24.136 -20.746 -1.080  1.00 97.04  ? 579  ARG   A NH2 1 
ATOM   2210 N  N   . VAL   A 1 317 ? -16.160 -22.669 -1.117  0.50 69.80  ? 580  VAL   A N   1 
ATOM   2211 C  CA  . VAL   A 1 317 ? -15.366 -23.887 -0.775  0.50 69.32  ? 580  VAL   A CA  1 
ATOM   2212 C  C   . VAL   A 1 317 ? -15.376 -24.068 0.745   0.50 69.50  ? 580  VAL   A C   1 
ATOM   2213 O  O   . VAL   A 1 317 ? -15.209 -23.059 1.455   0.50 62.49  ? 580  VAL   A O   1 
ATOM   2214 C  CB  . VAL   A 1 317 ? -13.924 -23.780 -1.307  0.50 68.62  ? 580  VAL   A CB  1 
ATOM   2215 C  CG1 . VAL   A 1 317 ? -13.153 -25.074 -1.110  0.50 67.72  ? 580  VAL   A CG1 1 
ATOM   2216 C  CG2 . VAL   A 1 317 ? -13.890 -23.356 -2.765  0.50 69.44  ? 580  VAL   A CG2 1 
ATOM   2217 N  N   . GLN   A 1 318 ? -15.563 -25.308 1.211   0.50 73.99  ? 581  GLN   A N   1 
ATOM   2218 C  CA  . GLN   A 1 318 ? -15.567 -25.676 2.653   0.50 77.50  ? 581  GLN   A CA  1 
ATOM   2219 C  C   . GLN   A 1 318 ? -14.132 -25.922 3.129   0.50 80.84  ? 581  GLN   A C   1 
ATOM   2220 O  O   . GLN   A 1 318 ? -13.460 -26.798 2.548   0.50 76.32  ? 581  GLN   A O   1 
ATOM   2221 C  CB  . GLN   A 1 318 ? -16.422 -26.920 2.897   0.50 76.65  ? 581  GLN   A CB  1 
ATOM   2222 C  CG  . GLN   A 1 318 ? -17.916 -26.643 2.850   0.50 78.18  ? 581  GLN   A CG  1 
ATOM   2223 C  CD  . GLN   A 1 318 ? -18.644 -27.296 3.999   0.50 79.95  ? 581  GLN   A CD  1 
ATOM   2224 O  OE1 . GLN   A 1 318 ? -18.247 -28.349 4.496   0.50 82.48  ? 581  GLN   A OE1 1 
ATOM   2225 N  NE2 . GLN   A 1 318 ? -19.719 -26.663 4.440   0.50 79.82  ? 581  GLN   A NE2 1 
ATOM   2226 N  N   . ARG   A 1 319 ? -13.702 -25.176 4.153   0.50 89.20  ? 582  ARG   A N   1 
ATOM   2227 C  CA  . ARG   A 1 319 ? -12.393 -25.329 4.846   0.50 93.07  ? 582  ARG   A CA  1 
ATOM   2228 C  C   . ARG   A 1 319 ? -12.646 -25.837 6.265   0.50 102.00 ? 582  ARG   A C   1 
ATOM   2229 O  O   . ARG   A 1 319 ? -13.457 -25.256 6.983   0.50 100.41 ? 582  ARG   A O   1 
ATOM   2230 C  CB  . ARG   A 1 319 ? -11.651 -23.989 4.857   0.50 88.90  ? 582  ARG   A CB  1 
ATOM   2231 C  CG  . ARG   A 1 319 ? -10.200 -24.078 5.308   0.50 85.71  ? 582  ARG   A CG  1 
ATOM   2232 C  CD  . ARG   A 1 319 ? -9.385  -22.918 4.772   0.50 83.42  ? 582  ARG   A CD  1 
ATOM   2233 N  NE  . ARG   A 1 319 ? -10.116 -21.662 4.855   0.50 82.16  ? 582  ARG   A NE  1 
ATOM   2234 C  CZ  . ARG   A 1 319 ? -9.838  -20.680 5.705   0.50 82.05  ? 582  ARG   A CZ  1 
ATOM   2235 N  NH1 . ARG   A 1 319 ? -8.830  -20.801 6.552   0.50 83.97  ? 582  ARG   A NH1 1 
ATOM   2236 N  NH2 . ARG   A 1 319 ? -10.566 -19.578 5.701   0.50 78.84  ? 582  ARG   A NH2 1 
ATOM   2237 N  N   . PRO   A 1 320 ? -11.980 -26.931 6.717   1.00 112.51 ? 583  PRO   A N   1 
ATOM   2238 C  CA  . PRO   A 1 320 ? -12.218 -27.475 8.067   1.00 117.71 ? 583  PRO   A CA  1 
ATOM   2239 C  C   . PRO   A 1 320 ? -11.810 -26.628 9.294   1.00 121.92 ? 583  PRO   A C   1 
ATOM   2240 O  O   . PRO   A 1 320 ? -12.242 -26.948 10.397  1.00 126.13 ? 583  PRO   A O   1 
ATOM   2241 C  CB  . PRO   A 1 320 ? -11.370 -28.766 8.122   1.00 115.54 ? 583  PRO   A CB  1 
ATOM   2242 C  CG  . PRO   A 1 320 ? -10.895 -29.030 6.702   1.00 113.18 ? 583  PRO   A CG  1 
ATOM   2243 C  CD  . PRO   A 1 320 ? -10.978 -27.710 5.961   1.00 115.36 ? 583  PRO   A CD  1 
ATOM   2244 N  N   . THR   A 1 321 ? -10.989 -25.593 9.095   1.00 119.89 ? 584  THR   A N   1 
ATOM   2245 C  CA  . THR   A 1 321 ? -10.517 -24.649 10.146  1.00 112.05 ? 584  THR   A CA  1 
ATOM   2246 C  C   . THR   A 1 321 ? -11.726 -23.951 10.790  1.00 98.52  ? 584  THR   A C   1 
ATOM   2247 O  O   . THR   A 1 321 ? -11.700 -23.764 12.022  1.00 90.39  ? 584  THR   A O   1 
ATOM   2248 C  CB  . THR   A 1 321 ? -9.538  -23.638 9.534   1.00 121.90 ? 584  THR   A CB  1 
ATOM   2249 O  OG1 . THR   A 1 321 ? -10.281 -22.843 8.609   1.00 120.81 ? 584  THR   A OG1 1 
ATOM   2250 C  CG2 . THR   A 1 321 ? -8.365  -24.282 8.824   1.00 119.85 ? 584  THR   A CG2 1 
ATOM   2251 N  N   . THR   A 1 325 ? -15.495 -25.647 10.712  0.50 102.47 ? 588  THR   A N   1 
ATOM   2252 C  CA  . THR   A 1 325 ? -15.902 -25.649 9.280   0.50 102.00 ? 588  THR   A CA  1 
ATOM   2253 C  C   . THR   A 1 325 ? -16.450 -24.266 8.908   0.50 98.42  ? 588  THR   A C   1 
ATOM   2254 O  O   . THR   A 1 325 ? -17.460 -23.847 9.505   0.50 98.15  ? 588  THR   A O   1 
ATOM   2255 C  CB  . THR   A 1 325 ? -16.922 -26.759 8.995   0.50 104.52 ? 588  THR   A CB  1 
ATOM   2256 O  OG1 . THR   A 1 325 ? -16.249 -28.016 9.076   0.50 105.25 ? 588  THR   A OG1 1 
ATOM   2257 C  CG2 . THR   A 1 325 ? -17.577 -26.629 7.638   0.50 107.58 ? 588  THR   A CG2 1 
ATOM   2258 N  N   . VAL   A 1 326 ? -15.794 -23.588 7.961   0.50 93.56  ? 589  VAL   A N   1 
ATOM   2259 C  CA  . VAL   A 1 326 ? -16.211 -22.258 7.424   0.50 91.35  ? 589  VAL   A CA  1 
ATOM   2260 C  C   . VAL   A 1 326 ? -16.479 -22.397 5.921   0.50 87.55  ? 589  VAL   A C   1 
ATOM   2261 O  O   . VAL   A 1 326 ? -16.119 -23.446 5.349   0.50 85.10  ? 589  VAL   A O   1 
ATOM   2262 C  CB  . VAL   A 1 326 ? -15.144 -21.182 7.696   0.50 90.30  ? 589  VAL   A CB  1 
ATOM   2263 C  CG1 . VAL   A 1 326 ? -14.869 -21.023 9.183   0.50 91.86  ? 589  VAL   A CG1 1 
ATOM   2264 C  CG2 . VAL   A 1 326 ? -13.857 -21.467 6.939   0.50 92.31  ? 589  VAL   A CG2 1 
ATOM   2265 N  N   . MET   A 1 327 ? -17.091 -21.373 5.318   0.50 82.31  ? 590  MET   A N   1 
ATOM   2266 C  CA  . MET   A 1 327 ? -17.304 -21.263 3.851   0.50 76.43  ? 590  MET   A CA  1 
ATOM   2267 C  C   . MET   A 1 327 ? -16.498 -20.074 3.326   0.50 72.23  ? 590  MET   A C   1 
ATOM   2268 O  O   . MET   A 1 327 ? -16.761 -18.943 3.772   0.50 69.46  ? 590  MET   A O   1 
ATOM   2269 C  CB  . MET   A 1 327 ? -18.783 -21.057 3.509   0.50 75.10  ? 590  MET   A CB  1 
ATOM   2270 C  CG  . MET   A 1 327 ? -19.071 -21.155 2.022   0.50 73.34  ? 590  MET   A CG  1 
ATOM   2271 S  SD  . MET   A 1 327 ? -18.821 -22.829 1.368   0.50 70.36  ? 590  MET   A SD  1 
ATOM   2272 C  CE  . MET   A 1 327 ? -20.290 -23.654 1.981   0.50 72.06  ? 590  MET   A CE  1 
ATOM   2273 N  N   . ASP   A 1 328 ? -15.550 -20.335 2.423   0.50 68.30  ? 591  ASP   A N   1 
ATOM   2274 C  CA  . ASP   A 1 328 ? -14.696 -19.304 1.778   0.50 66.77  ? 591  ASP   A CA  1 
ATOM   2275 C  C   . ASP   A 1 328 ? -15.370 -18.862 0.475   0.50 65.54  ? 591  ASP   A C   1 
ATOM   2276 O  O   . ASP   A 1 328 ? -15.879 -19.740 -0.243  0.50 62.14  ? 591  ASP   A O   1 
ATOM   2277 C  CB  . ASP   A 1 328 ? -13.285 -19.839 1.525   0.50 66.90  ? 591  ASP   A CB  1 
ATOM   2278 C  CG  . ASP   A 1 328 ? -12.614 -20.439 2.752   0.50 68.09  ? 591  ASP   A CG  1 
ATOM   2279 O  OD1 . ASP   A 1 328 ? -13.303 -20.626 3.783   0.50 64.66  ? 591  ASP   A OD1 1 
ATOM   2280 O  OD2 . ASP   A 1 328 ? -11.403 -20.722 2.665   0.50 65.72  ? 591  ASP   A OD2 1 
ATOM   2281 N  N   . ILE   A 1 329 ? -15.369 -17.554 0.196   1.00 62.64  ? 592  ILE   A N   1 
ATOM   2282 C  CA  . ILE   A 1 329 ? -15.947 -16.980 -1.047  1.00 62.47  ? 592  ILE   A CA  1 
ATOM   2283 C  C   . ILE   A 1 329 ? -14.787 -16.371 -1.816  1.00 67.90  ? 592  ILE   A C   1 
ATOM   2284 O  O   . ILE   A 1 329 ? -14.372 -15.240 -1.500  1.00 64.39  ? 592  ILE   A O   1 
ATOM   2285 C  CB  . ILE   A 1 329 ? -17.055 -15.950 -0.779  1.00 63.14  ? 592  ILE   A CB  1 
ATOM   2286 C  CG1 . ILE   A 1 329 ? -18.265 -16.585 -0.087  1.00 64.06  ? 592  ILE   A CG1 1 
ATOM   2287 C  CG2 . ILE   A 1 329 ? -17.432 -15.225 -2.067  1.00 61.31  ? 592  ILE   A CG2 1 
ATOM   2288 C  CD1 . ILE   A 1 329 ? -18.892 -17.744 -0.826  1.00 65.58  ? 592  ILE   A CD1 1 
ATOM   2289 N  N   . ILE   A 1 330 ? -14.335 -17.105 -2.829  1.00 69.98  ? 593  ILE   A N   1 
ATOM   2290 C  CA  . ILE   A 1 330 ? -13.124 -16.768 -3.622  1.00 70.25  ? 593  ILE   A CA  1 
ATOM   2291 C  C   . ILE   A 1 330 ? -13.561 -16.512 -5.065  1.00 63.67  ? 593  ILE   A C   1 
ATOM   2292 O  O   . ILE   A 1 330 ? -14.652 -16.939 -5.432  1.00 59.98  ? 593  ILE   A O   1 
ATOM   2293 C  CB  . ILE   A 1 330 ? -12.082 -17.897 -3.491  1.00 74.79  ? 593  ILE   A CB  1 
ATOM   2294 C  CG1 . ILE   A 1 330 ? -12.684 -19.278 -3.796  1.00 64.91  ? 593  ILE   A CG1 1 
ATOM   2295 C  CG2 . ILE   A 1 330 ? -11.444 -17.845 -2.105  1.00 72.51  ? 593  ILE   A CG2 1 
ATOM   2296 C  CD1 . ILE   A 1 330 ? -11.674 -20.398 -3.941  1.00 65.01  ? 593  ILE   A CD1 1 
ATOM   2297 N  N   . SER   A 1 331 ? -12.728 -15.822 -5.830  1.00 58.41  ? 594  SER   A N   1 
ATOM   2298 C  CA  . SER   A 1 331 ? -12.982 -15.495 -7.244  1.00 55.51  ? 594  SER   A CA  1 
ATOM   2299 C  C   . SER   A 1 331 ? -11.683 -15.639 -8.039  1.00 57.03  ? 594  SER   A C   1 
ATOM   2300 O  O   . SER   A 1 331 ? -10.594 -15.522 -7.451  1.00 54.71  ? 594  SER   A O   1 
ATOM   2301 C  CB  . SER   A 1 331 ? -13.558 -14.108 -7.351  1.00 54.34  ? 594  SER   A CB  1 
ATOM   2302 O  OG  . SER   A 1 331 ? -12.534 -13.124 -7.334  1.00 58.98  ? 594  SER   A OG  1 
ATOM   2303 N  N   . ARG   A 1 332 ? -11.802 -15.890 -9.350  0.50 55.70  ? 595  ARG   A N   1 
ATOM   2304 C  CA  . ARG   A 1 332 ? -10.664 -15.906 -10.310 0.50 53.83  ? 595  ARG   A CA  1 
ATOM   2305 C  C   . ARG   A 1 332 ? -11.199 -15.728 -11.734 0.50 54.75  ? 595  ARG   A C   1 
ATOM   2306 O  O   . ARG   A 1 332 ? -12.416 -15.901 -11.935 0.50 54.60  ? 595  ARG   A O   1 
ATOM   2307 C  CB  . ARG   A 1 332 ? -9.853  -17.198 -10.174 0.50 55.63  ? 595  ARG   A CB  1 
ATOM   2308 C  CG  . ARG   A 1 332 ? -10.417 -18.381 -10.945 0.50 54.66  ? 595  ARG   A CG  1 
ATOM   2309 C  CD  . ARG   A 1 332 ? -9.421  -19.523 -10.988 0.50 55.90  ? 595  ARG   A CD  1 
ATOM   2310 N  NE  . ARG   A 1 332 ? -8.116  -19.114 -11.495 0.50 54.81  ? 595  ARG   A NE  1 
ATOM   2311 C  CZ  . ARG   A 1 332 ? -6.995  -19.099 -10.779 0.50 55.03  ? 595  ARG   A CZ  1 
ATOM   2312 N  NH1 . ARG   A 1 332 ? -7.010  -19.467 -9.509  0.50 56.86  ? 595  ARG   A NH1 1 
ATOM   2313 N  NH2 . ARG   A 1 332 ? -5.859  -18.730 -11.340 0.50 54.53  ? 595  ARG   A NH2 1 
ATOM   2314 N  N   . ARG   A 1 333 ? -10.314 -15.398 -12.677 0.50 54.06  ? 596  ARG   A N   1 
ATOM   2315 C  CA  . ARG   A 1 333 ? -10.676 -14.941 -14.045 0.50 57.54  ? 596  ARG   A CA  1 
ATOM   2316 C  C   . ARG   A 1 333 ? -10.243 -15.966 -15.101 0.50 55.31  ? 596  ARG   A C   1 
ATOM   2317 O  O   . ARG   A 1 333 ? -10.512 -15.721 -16.299 0.50 55.26  ? 596  ARG   A O   1 
ATOM   2318 C  CB  . ARG   A 1 333 ? -9.994  -13.608 -14.358 0.50 61.76  ? 596  ARG   A CB  1 
ATOM   2319 C  CG  . ARG   A 1 333 ? -10.423 -12.445 -13.473 0.50 66.10  ? 596  ARG   A CG  1 
ATOM   2320 C  CD  . ARG   A 1 333 ? -10.555 -11.183 -14.306 0.50 69.51  ? 596  ARG   A CD  1 
ATOM   2321 N  NE  . ARG   A 1 333 ? -11.488 -11.400 -15.407 0.50 73.60  ? 596  ARG   A NE  1 
ATOM   2322 C  CZ  . ARG   A 1 333 ? -11.373 -10.867 -16.619 0.50 77.53  ? 596  ARG   A CZ  1 
ATOM   2323 N  NH1 . ARG   A 1 333 ? -10.355 -10.071 -16.904 0.50 78.78  ? 596  ARG   A NH1 1 
ATOM   2324 N  NH2 . ARG   A 1 333 ? -12.273 -11.144 -17.548 0.50 79.00  ? 596  ARG   A NH2 1 
ATOM   2325 N  N   . ASP   A 1 334 ? -9.576  -17.045 -14.686 0.50 50.19  ? 597  ASP   A N   1 
ATOM   2326 C  CA  . ASP   A 1 334 ? -9.024  -18.076 -15.606 0.50 47.98  ? 597  ASP   A CA  1 
ATOM   2327 C  C   . ASP   A 1 334 ? -9.450  -19.461 -15.110 0.50 43.42  ? 597  ASP   A C   1 
ATOM   2328 O  O   . ASP   A 1 334 ? -10.229 -19.521 -14.135 0.50 41.57  ? 597  ASP   A O   1 
ATOM   2329 C  CB  . ASP   A 1 334 ? -7.504  -17.940 -15.746 0.50 48.38  ? 597  ASP   A CB  1 
ATOM   2330 C  CG  . ASP   A 1 334 ? -6.722  -18.449 -14.549 0.50 49.77  ? 597  ASP   A CG  1 
ATOM   2331 O  OD1 . ASP   A 1 334 ? -7.342  -18.637 -13.485 0.50 51.98  ? 597  ASP   A OD1 1 
ATOM   2332 O  OD2 . ASP   A 1 334 ? -5.496  -18.658 -14.692 0.50 54.42  ? 597  ASP   A OD2 1 
ATOM   2333 N  N   . GLN   A 1 335 ? -8.968  -20.523 -15.771 1.00 41.60  ? 598  GLN   A N   1 
ATOM   2334 C  CA  . GLN   A 1 335 ? -9.294  -21.936 -15.439 1.00 39.01  ? 598  GLN   A CA  1 
ATOM   2335 C  C   . GLN   A 1 335 ? -10.674 -22.283 -15.982 1.00 41.33  ? 598  GLN   A C   1 
ATOM   2336 O  O   . GLN   A 1 335 ? -11.494 -21.382 -16.219 1.00 40.81  ? 598  GLN   A O   1 
ATOM   2337 C  CB  . GLN   A 1 335 ? -9.244  -22.317 -13.961 1.00 38.89  ? 598  GLN   A CB  1 
ATOM   2338 C  CG  . GLN   A 1 335 ? -7.889  -22.016 -13.350 1.00 41.30  ? 598  GLN   A CG  1 
ATOM   2339 C  CD  . GLN   A 1 335 ? -7.642  -22.776 -12.074 1.00 45.42  ? 598  GLN   A CD  1 
ATOM   2340 O  OE1 . GLN   A 1 335 ? -8.538  -23.394 -11.506 1.00 55.60  ? 598  GLN   A OE1 1 
ATOM   2341 N  NE2 . GLN   A 1 335 ? -6.383  -22.811 -11.681 1.00 45.96  ? 598  GLN   A NE2 1 
ATOM   2342 N  N   . ARG   A 1 336 ? -10.877 -23.574 -16.202 1.00 40.36  ? 599  ARG   A N   1 
ATOM   2343 C  CA  . ARG   A 1 336 ? -12.177 -24.122 -16.639 1.00 45.42  ? 599  ARG   A CA  1 
ATOM   2344 C  C   . ARG   A 1 336 ? -13.012 -24.343 -15.392 1.00 47.88  ? 599  ARG   A C   1 
ATOM   2345 O  O   . ARG   A 1 336 ? -12.536 -24.940 -14.431 1.00 48.93  ? 599  ARG   A O   1 
ATOM   2346 C  CB  . ARG   A 1 336 ? -12.069 -25.447 -17.404 1.00 37.71  ? 599  ARG   A CB  1 
ATOM   2347 C  CG  . ARG   A 1 336 ? -13.404 -26.093 -17.762 1.00 36.35  ? 599  ARG   A CG  1 
ATOM   2348 C  CD  . ARG   A 1 336 ? -14.059 -25.367 -18.936 1.00 37.05  ? 599  ARG   A CD  1 
ATOM   2349 N  NE  . ARG   A 1 336 ? -13.279 -25.621 -20.121 1.00 34.09  ? 599  ARG   A NE  1 
ATOM   2350 C  CZ  . ARG   A 1 336 ? -13.020 -24.743 -21.074 1.00 32.36  ? 599  ARG   A CZ  1 
ATOM   2351 N  NH1 . ARG   A 1 336 ? -13.483 -23.505 -20.981 1.00 32.63  ? 599  ARG   A NH1 1 
ATOM   2352 N  NH2 . ARG   A 1 336 ? -12.283 -25.121 -22.110 1.00 31.04  ? 599  ARG   A NH2 1 
ATOM   2353 N  N   . GLY   A 1 337 ? -14.290 -23.969 -15.438 0.50 53.48  ? 600  GLY   A N   1 
ATOM   2354 C  CA  . GLY   A 1 337 ? -15.240 -24.249 -14.345 0.50 56.33  ? 600  GLY   A CA  1 
ATOM   2355 C  C   . GLY   A 1 337 ? -16.679 -24.070 -14.783 0.50 60.49  ? 600  GLY   A C   1 
ATOM   2356 O  O   . GLY   A 1 337 ? -17.443 -23.463 -14.020 0.50 67.18  ? 600  GLY   A O   1 
ATOM   2357 N  N   . SER   A 1 338 ? -17.034 -24.573 -15.970 0.50 62.32  ? 601  SER   A N   1 
ATOM   2358 C  CA  . SER   A 1 338 ? -18.420 -24.586 -16.507 0.50 58.10  ? 601  SER   A CA  1 
ATOM   2359 C  C   . SER   A 1 338 ? -19.151 -25.798 -15.926 0.50 57.08  ? 601  SER   A C   1 
ATOM   2360 O  O   . SER   A 1 338 ? -18.587 -26.440 -15.017 0.50 54.41  ? 601  SER   A O   1 
ATOM   2361 C  CB  . SER   A 1 338 ? -18.432 -24.627 -18.018 0.50 59.23  ? 601  SER   A CB  1 
ATOM   2362 O  OG  . SER   A 1 338 ? -17.404 -23.818 -18.573 0.50 63.48  ? 601  SER   A OG  1 
ATOM   2363 N  N   . GLY   A 1 339 ? -20.252 -26.178 -16.584 0.50 57.26  ? 602  GLY   A N   1 
ATOM   2364 C  CA  . GLY   A 1 339 ? -20.908 -27.455 -16.261 0.50 55.32  ? 602  GLY   A CA  1 
ATOM   2365 C  C   . GLY   A 1 339 ? -20.187 -28.521 -17.069 0.50 51.64  ? 602  GLY   A C   1 
ATOM   2366 O  O   . GLY   A 1 339 ? -19.530 -28.139 -18.051 0.50 46.52  ? 602  GLY   A O   1 
ATOM   2367 N  N   . GLN   A 1 340 ? -20.322 -29.798 -16.718 0.50 49.04  ? 603  GLN   A N   1 
ATOM   2368 C  CA  . GLN   A 1 340 ? -19.525 -30.878 -17.364 0.50 49.88  ? 603  GLN   A CA  1 
ATOM   2369 C  C   . GLN   A 1 340 ? -19.722 -30.942 -18.884 0.50 48.08  ? 603  GLN   A C   1 
ATOM   2370 O  O   . GLN   A 1 340 ? -18.717 -31.103 -19.590 0.50 43.03  ? 603  GLN   A O   1 
ATOM   2371 C  CB  . GLN   A 1 340 ? -19.898 -32.212 -16.716 0.50 53.74  ? 603  GLN   A CB  1 
ATOM   2372 C  CG  . GLN   A 1 340 ? -20.025 -32.131 -15.203 0.50 56.74  ? 603  GLN   A CG  1 
ATOM   2373 C  CD  . GLN   A 1 340 ? -20.650 -33.372 -14.618 0.50 58.70  ? 603  GLN   A CD  1 
ATOM   2374 O  OE1 . GLN   A 1 340 ? -21.184 -33.359 -13.512 0.50 60.51  ? 603  GLN   A OE1 1 
ATOM   2375 N  NE2 . GLN   A 1 340 ? -20.599 -34.460 -15.370 0.50 59.21  ? 603  GLN   A NE2 1 
ATOM   2376 N  N   . VAL   A 1 341 ? -20.957 -30.830 -19.369 1.00 46.62  ? 604  VAL   A N   1 
ATOM   2377 C  CA  . VAL   A 1 341 ? -21.229 -31.006 -20.828 1.00 44.81  ? 604  VAL   A CA  1 
ATOM   2378 C  C   . VAL   A 1 341 ? -20.633 -29.857 -21.649 1.00 40.31  ? 604  VAL   A C   1 
ATOM   2379 O  O   . VAL   A 1 341 ? -19.990 -30.144 -22.662 1.00 36.68  ? 604  VAL   A O   1 
ATOM   2380 C  CB  . VAL   A 1 341 ? -22.735 -31.167 -21.089 1.00 47.22  ? 604  VAL   A CB  1 
ATOM   2381 C  CG1 . VAL   A 1 341 ? -23.032 -31.221 -22.577 1.00 55.58  ? 604  VAL   A CG1 1 
ATOM   2382 C  CG2 . VAL   A 1 341 ? -23.295 -32.391 -20.384 1.00 50.85  ? 604  VAL   A CG2 1 
ATOM   2383 N  N   . VAL   A 1 342 ? -20.863 -28.607 -21.245 1.00 38.24  ? 605  VAL   A N   1 
ATOM   2384 C  CA  . VAL   A 1 342 ? -20.209 -27.470 -21.954 1.00 37.85  ? 605  VAL   A CA  1 
ATOM   2385 C  C   . VAL   A 1 342 ? -18.687 -27.599 -21.808 1.00 34.24  ? 605  VAL   A C   1 
ATOM   2386 O  O   . VAL   A 1 342 ? -17.985 -27.351 -22.778 1.00 32.67  ? 605  VAL   A O   1 
ATOM   2387 C  CB  . VAL   A 1 342 ? -20.730 -26.118 -21.437 1.00 41.53  ? 605  VAL   A CB  1 
ATOM   2388 C  CG1 . VAL   A 1 342 ? -19.992 -24.949 -22.066 1.00 40.76  ? 605  VAL   A CG1 1 
ATOM   2389 C  CG2 . VAL   A 1 342 ? -22.230 -25.981 -21.647 1.00 42.15  ? 605  VAL   A CG2 1 
ATOM   2390 N  N   . THR   A 1 343 ? -18.221 -27.998 -20.628 1.00 30.29  ? 606  THR   A N   1 
ATOM   2391 C  CA  . THR   A 1 343 ? -16.766 -28.181 -20.397 1.00 34.37  ? 606  THR   A CA  1 
ATOM   2392 C  C   . THR   A 1 343 ? -16.197 -29.152 -21.442 1.00 30.84  ? 606  THR   A C   1 
ATOM   2393 O  O   . THR   A 1 343 ? -15.137 -28.859 -21.983 1.00 30.60  ? 606  THR   A O   1 
ATOM   2394 C  CB  . THR   A 1 343 ? -16.490 -28.640 -18.958 1.00 35.96  ? 606  THR   A CB  1 
ATOM   2395 O  OG1 . THR   A 1 343 ? -16.830 -27.578 -18.069 1.00 38.10  ? 606  THR   A OG1 1 
ATOM   2396 C  CG2 . THR   A 1 343 ? -15.052 -29.054 -18.737 1.00 37.88  ? 606  THR   A CG2 1 
ATOM   2397 N  N   . TYR   A 1 344 ? -16.911 -30.245 -21.715 1.00 30.06  ? 607  TYR   A N   1 
ATOM   2398 C  CA  . TYR   A 1 344 ? -16.420 -31.259 -22.677 1.00 30.08  ? 607  TYR   A CA  1 
ATOM   2399 C  C   . TYR   A 1 344 ? -16.291 -30.627 -24.062 1.00 30.10  ? 607  TYR   A C   1 
ATOM   2400 O  O   . TYR   A 1 344 ? -15.268 -30.835 -24.708 1.00 27.19  ? 607  TYR   A O   1 
ATOM   2401 C  CB  . TYR   A 1 344 ? -17.345 -32.475 -22.726 1.00 32.41  ? 607  TYR   A CB  1 
ATOM   2402 C  CG  . TYR   A 1 344 ? -16.980 -33.502 -23.766 1.00 30.29  ? 607  TYR   A CG  1 
ATOM   2403 C  CD1 . TYR   A 1 344 ? -16.052 -34.493 -23.497 1.00 31.10  ? 607  TYR   A CD1 1 
ATOM   2404 C  CD2 . TYR   A 1 344 ? -17.558 -33.483 -25.023 1.00 29.49  ? 607  TYR   A CD2 1 
ATOM   2405 C  CE1 . TYR   A 1 344 ? -15.708 -35.438 -24.447 1.00 31.65  ? 607  TYR   A CE1 1 
ATOM   2406 C  CE2 . TYR   A 1 344 ? -17.226 -34.420 -25.985 1.00 32.37  ? 607  TYR   A CE2 1 
ATOM   2407 C  CZ  . TYR   A 1 344 ? -16.297 -35.402 -25.697 1.00 32.84  ? 607  TYR   A CZ  1 
ATOM   2408 O  OH  . TYR   A 1 344 ? -15.964 -36.328 -26.640 1.00 34.57  ? 607  TYR   A OH  1 
ATOM   2409 N  N   . GLY   A 1 345 ? -17.319 -29.892 -24.484 1.00 26.84  ? 608  GLY   A N   1 
ATOM   2410 C  CA  . GLY   A 1 345 ? -17.304 -29.325 -25.848 1.00 24.50  ? 608  GLY   A CA  1 
ATOM   2411 C  C   . GLY   A 1 345 ? -16.224 -28.250 -25.971 1.00 23.11  ? 608  GLY   A C   1 
ATOM   2412 O  O   . GLY   A 1 345 ? -15.511 -28.239 -26.960 1.00 28.76  ? 608  GLY   A O   1 
ATOM   2413 N  N   . LEU   A 1 346 ? -16.060 -27.390 -24.979 1.00 24.35  ? 609  LEU   A N   1 
ATOM   2414 C  CA  . LEU   A 1 346 ? -15.057 -26.323 -25.097 1.00 27.49  ? 609  LEU   A CA  1 
ATOM   2415 C  C   . LEU   A 1 346 ? -13.630 -26.883 -24.921 1.00 25.48  ? 609  LEU   A C   1 
ATOM   2416 O  O   . LEU   A 1 346 ? -12.737 -26.329 -25.584 1.00 26.28  ? 609  LEU   A O   1 
ATOM   2417 C  CB  . LEU   A 1 346 ? -15.366 -25.218 -24.094 1.00 27.68  ? 609  LEU   A CB  1 
ATOM   2418 C  CG  . LEU   A 1 346 ? -16.680 -24.477 -24.311 1.00 30.01  ? 609  LEU   A CG  1 
ATOM   2419 C  CD1 . LEU   A 1 346 ? -16.835 -23.411 -23.260 1.00 36.23  ? 609  LEU   A CD1 1 
ATOM   2420 C  CD2 . LEU   A 1 346 ? -16.744 -23.904 -25.720 1.00 30.79  ? 609  LEU   A CD2 1 
ATOM   2421 N  N   . ASN   A 1 347 ? -13.440 -27.896 -24.059 1.00 28.11  ? 610  ASN   A N   1 
ATOM   2422 C  CA  . ASN   A 1 347 ? -12.159 -28.647 -23.940 1.00 25.72  ? 610  ASN   A CA  1 
ATOM   2423 C  C   . ASN   A 1 347 ? -11.831 -29.248 -25.309 1.00 25.69  ? 610  ASN   A C   1 
ATOM   2424 O  O   . ASN   A 1 347 ? -10.683 -29.082 -25.765 1.00 24.10  ? 610  ASN   A O   1 
ATOM   2425 C  CB  . ASN   A 1 347 ? -12.214 -29.677 -22.814 1.00 25.40  ? 610  ASN   A CB  1 
ATOM   2426 C  CG  . ASN   A 1 347 ? -12.040 -29.058 -21.442 1.00 26.46  ? 610  ASN   A CG  1 
ATOM   2427 O  OD1 . ASN   A 1 347 ? -11.682 -27.903 -21.292 1.00 28.89  ? 610  ASN   A OD1 1 
ATOM   2428 N  ND2 . ASN   A 1 347 ? -12.197 -29.856 -20.410 1.00 29.01  ? 610  ASN   A ND2 1 
ATOM   2429 N  N   . THR   A 1 348 ? -12.801 -29.879 -25.989 1.00 23.21  ? 611  THR   A N   1 
ATOM   2430 C  CA  . THR   A 1 348 ? -12.572 -30.480 -27.319 1.00 22.66  ? 611  THR   A CA  1 
ATOM   2431 C  C   . THR   A 1 348 ? -12.131 -29.371 -28.282 1.00 24.97  ? 611  THR   A C   1 
ATOM   2432 O  O   . THR   A 1 348 ? -11.179 -29.575 -29.027 1.00 24.41  ? 611  THR   A O   1 
ATOM   2433 C  CB  . THR   A 1 348 ? -13.780 -31.232 -27.832 1.00 24.26  ? 611  THR   A CB  1 
ATOM   2434 O  OG1 . THR   A 1 348 ? -14.185 -32.232 -26.887 1.00 23.55  ? 611  THR   A OG1 1 
ATOM   2435 C  CG2 . THR   A 1 348 ? -13.519 -31.845 -29.171 1.00 23.69  ? 611  THR   A CG2 1 
ATOM   2436 N  N   . PHE   A 1 349 ? -12.839 -28.248 -28.294 1.00 24.26  ? 612  PHE   A N   1 
ATOM   2437 C  CA  . PHE   A 1 349 ? -12.521 -27.111 -29.195 1.00 25.73  ? 612  PHE   A CA  1 
ATOM   2438 C  C   . PHE   A 1 349 ? -11.076 -26.634 -29.001 1.00 24.88  ? 612  PHE   A C   1 
ATOM   2439 O  O   . PHE   A 1 349 ? -10.335 -26.552 -29.992 1.00 24.83  ? 612  PHE   A O   1 
ATOM   2440 C  CB  . PHE   A 1 349 ? -13.495 -25.962 -28.933 1.00 24.73  ? 612  PHE   A CB  1 
ATOM   2441 C  CG  . PHE   A 1 349 ? -13.216 -24.802 -29.833 1.00 23.25  ? 612  PHE   A CG  1 
ATOM   2442 C  CD1 . PHE   A 1 349 ? -13.748 -24.769 -31.104 1.00 26.35  ? 612  PHE   A CD1 1 
ATOM   2443 C  CD2 . PHE   A 1 349 ? -12.397 -23.755 -29.398 1.00 25.07  ? 612  PHE   A CD2 1 
ATOM   2444 C  CE1 . PHE   A 1 349 ? -13.457 -23.701 -31.950 1.00 28.48  ? 612  PHE   A CE1 1 
ATOM   2445 C  CE2 . PHE   A 1 349 ? -12.137 -22.681 -30.238 1.00 27.95  ? 612  PHE   A CE2 1 
ATOM   2446 C  CZ  . PHE   A 1 349 ? -12.644 -22.668 -31.509 1.00 29.09  ? 612  PHE   A CZ  1 
ATOM   2447 N  N   . THR   A 1 350 ? -10.698 -26.334 -27.756 1.00 22.97  ? 613  THR   A N   1 
ATOM   2448 C  CA  . THR   A 1 350 ? -9.408  -25.717 -27.419 1.00 28.06  ? 613  THR   A CA  1 
ATOM   2449 C  C   . THR   A 1 350 ? -8.277  -26.737 -27.640 1.00 26.06  ? 613  THR   A C   1 
ATOM   2450 O  O   . THR   A 1 350 ? -7.206  -26.333 -28.096 1.00 26.94  ? 613  THR   A O   1 
ATOM   2451 C  CB  . THR   A 1 350 ? -9.456  -25.103 -26.023 1.00 29.65  ? 613  THR   A CB  1 
ATOM   2452 O  OG1 . THR   A 1 350 ? -10.401 -24.030 -26.137 1.00 28.92  ? 613  THR   A OG1 1 
ATOM   2453 C  CG2 . THR   A 1 350 ? -8.083  -24.601 -25.632 1.00 31.29  ? 613  THR   A CG2 1 
ATOM   2454 N  N   . ASN   A 1 351 ? -8.562  -28.029 -27.435 1.00 25.46  ? 614  ASN   A N   1 
ATOM   2455 C  CA  . ASN   A 1 351 ? -7.600  -29.136 -27.682 1.00 24.90  ? 614  ASN   A CA  1 
ATOM   2456 C  C   . ASN   A 1 351 ? -7.399  -29.256 -29.186 1.00 24.71  ? 614  ASN   A C   1 
ATOM   2457 O  O   . ASN   A 1 351 ? -6.221  -29.355 -29.617 1.00 23.71  ? 614  ASN   A O   1 
ATOM   2458 C  CB  . ASN   A 1 351 ? -8.007  -30.420 -26.953 1.00 22.99  ? 614  ASN   A CB  1 
ATOM   2459 C  CG  . ASN   A 1 351 ? -6.831  -31.349 -26.685 1.00 29.43  ? 614  ASN   A CG  1 
ATOM   2460 O  OD1 . ASN   A 1 351 ? -5.671  -31.013 -26.958 1.00 26.66  ? 614  ASN   A OD1 1 
ATOM   2461 N  ND2 . ASN   A 1 351 ? -7.121  -32.514 -26.126 1.00 30.00  ? 614  ASN   A ND2 1 
ATOM   2462 N  N   . MET   A 1 352 ? -8.483  -29.174 -29.977 1.00 21.64  ? 615  MET   A N   1 
ATOM   2463 C  CA  . MET   A 1 352 ? -8.328  -29.254 -31.440 1.00 24.60  ? 615  MET   A CA  1 
ATOM   2464 C  C   . MET   A 1 352 ? -7.418  -28.103 -31.885 1.00 26.33  ? 615  MET   A C   1 
ATOM   2465 O  O   . MET   A 1 352 ? -6.540  -28.330 -32.773 1.00 24.84  ? 615  MET   A O   1 
ATOM   2466 C  CB  . MET   A 1 352 ? -9.667  -29.179 -32.188 1.00 24.88  ? 615  MET   A CB  1 
ATOM   2467 C  CG  . MET   A 1 352 ? -10.461 -30.412 -32.068 1.00 26.31  ? 615  MET   A CG  1 
ATOM   2468 S  SD  . MET   A 1 352 ? -12.228 -30.182 -32.693 1.00 31.52  ? 615  MET   A SD  1 
ATOM   2469 C  CE  . MET   A 1 352 ? -11.947 -29.914 -34.414 1.00 25.28  ? 615  MET   A CE  1 
ATOM   2470 N  N   . GLU   A 1 353 ? -7.629  -26.943 -31.302 1.00 24.36  ? 616  GLU   A N   1 
ATOM   2471 C  CA  . GLU   A 1 353 ? -6.914  -25.702 -31.708 1.00 26.77  ? 616  GLU   A CA  1 
ATOM   2472 C  C   . GLU   A 1 353 ? -5.425  -25.882 -31.364 1.00 27.95  ? 616  GLU   A C   1 
ATOM   2473 O  O   . GLU   A 1 353 ? -4.562  -25.657 -32.209 1.00 26.69  ? 616  GLU   A O   1 
ATOM   2474 C  CB  . GLU   A 1 353 ? -7.551  -24.539 -30.950 1.00 29.54  ? 616  GLU   A CB  1 
ATOM   2475 C  CG  . GLU   A 1 353 ? -6.884  -23.196 -31.201 1.00 32.12  ? 616  GLU   A CG  1 
ATOM   2476 C  CD  . GLU   A 1 353 ? -7.205  -22.195 -30.107 1.00 34.96  ? 616  GLU   A CD  1 
ATOM   2477 O  OE1 . GLU   A 1 353 ? -8.430  -21.886 -29.958 1.00 35.09  ? 616  GLU   A OE1 1 
ATOM   2478 O  OE2 . GLU   A 1 353 ? -6.242  -21.822 -29.304 1.00 34.64  ? 616  GLU   A OE2 1 
ATOM   2479 N  N   . ALA   A 1 354 ? -5.142  -26.257 -30.129 1.00 28.09  ? 617  ALA   A N   1 
ATOM   2480 C  CA  . ALA   A 1 354 ? -3.782  -26.497 -29.613 1.00 27.75  ? 617  ALA   A CA  1 
ATOM   2481 C  C   . ALA   A 1 354 ? -3.067  -27.546 -30.457 1.00 27.16  ? 617  ALA   A C   1 
ATOM   2482 O  O   . ALA   A 1 354 ? -1.899  -27.302 -30.790 1.00 27.65  ? 617  ALA   A O   1 
ATOM   2483 C  CB  . ALA   A 1 354 ? -3.869  -26.909 -28.198 1.00 25.33  ? 617  ALA   A CB  1 
ATOM   2484 N  N   . GLN   A 1 355 ? -3.717  -28.668 -30.812 1.00 24.52  ? 618  GLN   A N   1 
ATOM   2485 C  CA  . GLN   A 1 355 ? -3.034  -29.723 -31.596 1.00 23.97  ? 618  GLN   A CA  1 
ATOM   2486 C  C   . GLN   A 1 355 ? -2.822  -29.285 -33.060 1.00 26.95  ? 618  GLN   A C   1 
ATOM   2487 O  O   . GLN   A 1 355 ? -1.812  -29.712 -33.683 1.00 25.20  ? 618  GLN   A O   1 
ATOM   2488 C  CB  . GLN   A 1 355 ? -3.752  -31.075 -31.498 1.00 23.48  ? 618  GLN   A CB  1 
ATOM   2489 C  CG  . GLN   A 1 355 ? -3.972  -31.576 -30.092 1.00 23.66  ? 618  GLN   A CG  1 
ATOM   2490 C  CD  . GLN   A 1 355 ? -2.710  -31.700 -29.282 1.00 26.53  ? 618  GLN   A CD  1 
ATOM   2491 O  OE1 . GLN   A 1 355 ? -1.643  -32.090 -29.755 1.00 26.16  ? 618  GLN   A OE1 1 
ATOM   2492 N  NE2 . GLN   A 1 355 ? -2.851  -31.412 -28.008 1.00 25.57  ? 618  GLN   A NE2 1 
ATOM   2493 N  N   . LEU   A 1 356 ? -3.699  -28.491 -33.675 1.00 26.05  ? 619  LEU   A N   1 
ATOM   2494 C  CA  . LEU   A 1 356 ? -3.400  -27.965 -35.052 1.00 27.00  ? 619  LEU   A CA  1 
ATOM   2495 C  C   . LEU   A 1 356 ? -2.157  -27.057 -34.991 1.00 26.77  ? 619  LEU   A C   1 
ATOM   2496 O  O   . LEU   A 1 356 ? -1.383  -27.054 -35.927 1.00 30.18  ? 619  LEU   A O   1 
ATOM   2497 C  CB  . LEU   A 1 356 ? -4.572  -27.123 -35.577 1.00 29.08  ? 619  LEU   A CB  1 
ATOM   2498 C  CG  . LEU   A 1 356 ? -5.701  -27.879 -36.254 1.00 31.60  ? 619  LEU   A CG  1 
ATOM   2499 C  CD1 . LEU   A 1 356 ? -6.815  -26.913 -36.632 1.00 30.69  ? 619  LEU   A CD1 1 
ATOM   2500 C  CD2 . LEU   A 1 356 ? -5.214  -28.614 -37.506 1.00 33.69  ? 619  LEU   A CD2 1 
ATOM   2501 N  N   . ILE   A 1 357 ? -2.034  -26.259 -33.957 1.00 26.33  ? 620  ILE   A N   1 
ATOM   2502 C  CA  . ILE   A 1 357 ? -0.881  -25.312 -33.823 1.00 29.49  ? 620  ILE   A CA  1 
ATOM   2503 C  C   . ILE   A 1 357 ? 0.398   -26.138 -33.606 1.00 34.08  ? 620  ILE   A C   1 
ATOM   2504 O  O   . ILE   A 1 357 ? 1.380   -25.877 -34.309 1.00 29.69  ? 620  ILE   A O   1 
ATOM   2505 C  CB  . ILE   A 1 357 ? -1.137  -24.302 -32.706 1.00 28.94  ? 620  ILE   A CB  1 
ATOM   2506 C  CG1 . ILE   A 1 357 ? -2.273  -23.362 -33.131 1.00 29.52  ? 620  ILE   A CG1 1 
ATOM   2507 C  CG2 . ILE   A 1 357 ? 0.132   -23.529 -32.362 1.00 30.57  ? 620  ILE   A CG2 1 
ATOM   2508 C  CD1 . ILE   A 1 357 ? -2.845  -22.562 -32.027 1.00 28.55  ? 620  ILE   A CD1 1 
ATOM   2509 N  N   . ARG   A 1 358 ? 0.342   -27.187 -32.774 1.00 29.66  ? 621  ARG   A N   1 
ATOM   2510 C  CA  . ARG   A 1 358 ? 1.501   -28.083 -32.624 1.00 28.74  ? 621  ARG   A CA  1 
ATOM   2511 C  C   . ARG   A 1 358 ? 1.828   -28.720 -33.973 1.00 29.83  ? 621  ARG   A C   1 
ATOM   2512 O  O   . ARG   A 1 358 ? 3.043   -28.804 -34.298 1.00 31.17  ? 621  ARG   A O   1 
ATOM   2513 C  CB  . ARG   A 1 358 ? 1.312   -29.109 -31.510 1.00 30.21  ? 621  ARG   A CB  1 
ATOM   2514 C  CG  . ARG   A 1 358 ? 2.564   -29.948 -31.335 1.00 28.14  ? 621  ARG   A CG  1 
ATOM   2515 C  CD  . ARG   A 1 358 ? 2.498   -30.802 -30.086 1.00 28.80  ? 621  ARG   A CD  1 
ATOM   2516 N  NE  . ARG   A 1 358 ? 3.671   -31.662 -30.031 1.00 26.86  ? 621  ARG   A NE  1 
ATOM   2517 C  CZ  . ARG   A 1 358 ? 3.872   -32.626 -29.127 1.00 29.74  ? 621  ARG   A CZ  1 
ATOM   2518 N  NH1 . ARG   A 1 358 ? 2.912   -33.018 -28.297 1.00 25.65  ? 621  ARG   A NH1 1 
ATOM   2519 N  NH2 . ARG   A 1 358 ? 5.027   -33.281 -29.135 1.00 31.81  ? 621  ARG   A NH2 1 
ATOM   2520 N  N   . GLN   A 1 359 ? 0.841   -29.146 -34.766 1.00 26.84  ? 622  GLN   A N   1 
ATOM   2521 C  CA  . GLN   A 1 359 ? 1.127   -29.643 -36.131 1.00 25.86  ? 622  GLN   A CA  1 
ATOM   2522 C  C   . GLN   A 1 359 ? 1.792   -28.512 -36.970 1.00 30.97  ? 622  GLN   A C   1 
ATOM   2523 O  O   . GLN   A 1 359 ? 2.752   -28.818 -37.728 1.00 33.21  ? 622  GLN   A O   1 
ATOM   2524 C  CB  . GLN   A 1 359 ? -0.095  -30.207 -36.839 1.00 27.15  ? 622  GLN   A CB  1 
ATOM   2525 C  CG  . GLN   A 1 359 ? -0.649  -31.499 -36.241 1.00 27.06  ? 622  GLN   A CG  1 
ATOM   2526 C  CD  . GLN   A 1 359 ? -1.644  -32.175 -37.139 1.00 28.55  ? 622  GLN   A CD  1 
ATOM   2527 O  OE1 . GLN   A 1 359 ? -1.306  -32.644 -38.222 1.00 28.05  ? 622  GLN   A OE1 1 
ATOM   2528 N  NE2 . GLN   A 1 359 ? -2.890  -32.284 -36.674 1.00 29.29  ? 622  GLN   A NE2 1 
ATOM   2529 N  N   . MET   A 1 360 ? 1.287   -27.284 -36.929 1.00 29.42  ? 623  MET   A N   1 
ATOM   2530 C  CA  . MET   A 1 360 ? 1.878   -26.180 -37.746 1.00 32.83  ? 623  MET   A CA  1 
ATOM   2531 C  C   . MET   A 1 360 ? 3.363   -26.045 -37.346 1.00 32.79  ? 623  MET   A C   1 
ATOM   2532 O  O   . MET   A 1 360 ? 4.194   -25.889 -38.250 1.00 32.34  ? 623  MET   A O   1 
ATOM   2533 C  CB  . MET   A 1 360 ? 1.181   -24.838 -37.495 1.00 32.93  ? 623  MET   A CB  1 
ATOM   2534 C  CG  . MET   A 1 360 ? -0.185  -24.704 -38.097 1.00 39.50  ? 623  MET   A CG  1 
ATOM   2535 S  SD  . MET   A 1 360 ? -0.869  -23.150 -37.467 1.00 39.17  ? 623  MET   A SD  1 
ATOM   2536 C  CE  . MET   A 1 360 ? -2.631  -23.459 -37.594 1.00 38.37  ? 623  MET   A CE  1 
ATOM   2537 N  N   . GLU   A 1 361 ? 3.654   -26.067 -36.045 1.00 30.59  ? 624  GLU   A N   1 
ATOM   2538 C  CA  . GLU   A 1 361 ? 5.031   -25.923 -35.540 1.00 32.06  ? 624  GLU   A CA  1 
ATOM   2539 C  C   . GLU   A 1 361 ? 5.903   -27.018 -36.135 1.00 37.05  ? 624  GLU   A C   1 
ATOM   2540 O  O   . GLU   A 1 361 ? 7.014   -26.701 -36.572 1.00 36.06  ? 624  GLU   A O   1 
ATOM   2541 C  CB  . GLU   A 1 361 ? 5.100   -25.958 -34.024 1.00 33.00  ? 624  GLU   A CB  1 
ATOM   2542 C  CG  . GLU   A 1 361 ? 6.476   -25.596 -33.503 1.00 36.00  ? 624  GLU   A CG  1 
ATOM   2543 C  CD  . GLU   A 1 361 ? 6.574   -25.321 -32.015 1.00 37.14  ? 624  GLU   A CD  1 
ATOM   2544 O  OE1 . GLU   A 1 361 ? 7.700   -25.316 -31.497 1.00 40.34  ? 624  GLU   A OE1 1 
ATOM   2545 O  OE2 . GLU   A 1 361 ? 5.538   -25.057 -31.375 1.00 35.48  ? 624  GLU   A OE2 1 
ATOM   2546 N  N   . GLY   A 1 362 ? 5.447   -28.272 -36.127 1.00 30.42  ? 625  GLY   A N   1 
ATOM   2547 C  CA  . GLY   A 1 362 ? 6.280   -29.383 -36.602 1.00 34.72  ? 625  GLY   A CA  1 
ATOM   2548 C  C   . GLY   A 1 362 ? 6.516   -29.232 -38.105 1.00 36.93  ? 625  GLY   A C   1 
ATOM   2549 O  O   . GLY   A 1 362 ? 7.590   -29.594 -38.583 1.00 32.81  ? 625  GLY   A O   1 
ATOM   2550 N  N   . GLU   A 1 363 ? 5.559   -28.661 -38.823 1.00 28.87  ? 626  GLU   A N   1 
ATOM   2551 C  CA  . GLU   A 1 363 ? 5.669   -28.545 -40.294 1.00 29.28  ? 626  GLU   A CA  1 
ATOM   2552 C  C   . GLU   A 1 363 ? 6.425   -27.259 -40.675 1.00 32.98  ? 626  GLU   A C   1 
ATOM   2553 O  O   . GLU   A 1 363 ? 6.527   -27.006 -41.851 1.00 32.74  ? 626  GLU   A O   1 
ATOM   2554 C  CB  . GLU   A 1 363 ? 4.281   -28.568 -40.937 1.00 30.75  ? 626  GLU   A CB  1 
ATOM   2555 C  CG  . GLU   A 1 363 ? 3.676   -29.989 -40.991 1.00 32.67  ? 626  GLU   A CG  1 
ATOM   2556 C  CD  . GLU   A 1 363 ? 2.264   -30.067 -41.541 1.00 41.49  ? 626  GLU   A CD  1 
ATOM   2557 O  OE1 . GLU   A 1 363 ? 2.033   -29.398 -42.600 1.00 35.39  ? 626  GLU   A OE1 1 
ATOM   2558 O  OE2 . GLU   A 1 363 ? 1.382   -30.777 -40.901 1.00 33.19  ? 626  GLU   A OE2 1 
ATOM   2559 N  N   . GLY   A 1 364 ? 6.886   -26.454 -39.735 1.00 32.15  ? 627  GLY   A N   1 
ATOM   2560 C  CA  . GLY   A 1 364 ? 7.658   -25.234 -40.053 1.00 40.20  ? 627  GLY   A CA  1 
ATOM   2561 C  C   . GLY   A 1 364 ? 6.799   -24.086 -40.571 1.00 47.73  ? 627  GLY   A C   1 
ATOM   2562 O  O   . GLY   A 1 364 ? 7.357   -23.225 -41.306 1.00 42.99  ? 627  GLY   A O   1 
ATOM   2563 N  N   . VAL   A 1 365 ? 5.500   -24.016 -40.237 1.00 36.14  ? 628  VAL   A N   1 
ATOM   2564 C  CA  . VAL   A 1 365 ? 4.622   -22.984 -40.860 1.00 38.04  ? 628  VAL   A CA  1 
ATOM   2565 C  C   . VAL   A 1 365 ? 5.017   -21.610 -40.291 1.00 41.29  ? 628  VAL   A C   1 
ATOM   2566 O  O   . VAL   A 1 365 ? 4.826   -20.591 -40.976 1.00 42.90  ? 628  VAL   A O   1 
ATOM   2567 C  CB  . VAL   A 1 365 ? 3.132   -23.326 -40.679 1.00 39.02  ? 628  VAL   A CB  1 
ATOM   2568 C  CG1 . VAL   A 1 365 ? 2.234   -22.217 -41.204 1.00 37.75  ? 628  VAL   A CG1 1 
ATOM   2569 C  CG2 . VAL   A 1 365 ? 2.798   -24.638 -41.380 1.00 38.29  ? 628  VAL   A CG2 1 
ATOM   2570 N  N   . PHE   A 1 366 ? 5.502   -21.581 -39.059 1.00 42.06  ? 629  PHE   A N   1 
ATOM   2571 C  CA  . PHE   A 1 366 ? 5.982   -20.367 -38.352 1.00 46.73  ? 629  PHE   A CA  1 
ATOM   2572 C  C   . PHE   A 1 366 ? 7.317   -20.721 -37.692 1.00 52.16  ? 629  PHE   A C   1 
ATOM   2573 O  O   . PHE   A 1 366 ? 7.564   -21.906 -37.485 1.00 51.45  ? 629  PHE   A O   1 
ATOM   2574 C  CB  . PHE   A 1 366 ? 4.944   -19.845 -37.354 1.00 44.56  ? 629  PHE   A CB  1 
ATOM   2575 C  CG  . PHE   A 1 366 ? 4.704   -20.721 -36.160 1.00 44.66  ? 629  PHE   A CG  1 
ATOM   2576 C  CD1 . PHE   A 1 366 ? 3.755   -21.731 -36.207 1.00 42.03  ? 629  PHE   A CD1 1 
ATOM   2577 C  CD2 . PHE   A 1 366 ? 5.394   -20.520 -34.975 1.00 43.55  ? 629  PHE   A CD2 1 
ATOM   2578 C  CE1 . PHE   A 1 366 ? 3.544   -22.551 -35.107 1.00 40.03  ? 629  PHE   A CE1 1 
ATOM   2579 C  CE2 . PHE   A 1 366 ? 5.175   -21.341 -33.883 1.00 49.42  ? 629  PHE   A CE2 1 
ATOM   2580 C  CZ  . PHE   A 1 366 ? 4.256   -22.366 -33.955 1.00 38.80  ? 629  PHE   A CZ  1 
ATOM   2581 N  N   . LYS   A 1 367 ? 8.160   -19.724 -37.424 1.00 56.37  ? 630  LYS   A N   1 
ATOM   2582 C  CA  . LYS   A 1 367 ? 9.575   -19.923 -37.025 1.00 57.85  ? 630  LYS   A CA  1 
ATOM   2583 C  C   . LYS   A 1 367 ? 9.678   -19.758 -35.514 1.00 51.86  ? 630  LYS   A C   1 
ATOM   2584 O  O   . LYS   A 1 367 ? 10.444  -20.505 -34.889 1.00 55.47  ? 630  LYS   A O   1 
ATOM   2585 C  CB  . LYS   A 1 367 ? 10.457  -18.932 -37.789 1.00 75.92  ? 630  LYS   A CB  1 
ATOM   2586 C  CG  . LYS   A 1 367 ? 11.953  -19.223 -37.761 1.00 90.27  ? 630  LYS   A CG  1 
ATOM   2587 C  CD  . LYS   A 1 367 ? 12.737  -18.418 -38.781 1.00 98.53  ? 630  LYS   A CD  1 
ATOM   2588 C  CE  . LYS   A 1 367 ? 14.222  -18.367 -38.489 1.00 105.60 ? 630  LYS   A CE  1 
ATOM   2589 N  NZ  . LYS   A 1 367 ? 14.523  -17.524 -37.306 1.00 109.99 ? 630  LYS   A NZ  1 
ATOM   2590 N  N   . SER   A 1 368 ? 8.886   -18.858 -34.938 1.00 45.16  ? 631  SER   A N   1 
ATOM   2591 C  CA  . SER   A 1 368 ? 9.011   -18.452 -33.514 1.00 47.46  ? 631  SER   A CA  1 
ATOM   2592 C  C   . SER   A 1 368 ? 7.689   -17.938 -32.962 1.00 42.45  ? 631  SER   A C   1 
ATOM   2593 O  O   . SER   A 1 368 ? 7.028   -17.188 -33.670 1.00 46.74  ? 631  SER   A O   1 
ATOM   2594 C  CB  . SER   A 1 368 ? 10.037  -17.370 -33.359 1.00 54.71  ? 631  SER   A CB  1 
ATOM   2595 O  OG  . SER   A 1 368 ? 9.895   -16.740 -32.094 1.00 61.78  ? 631  SER   A OG  1 
ATOM   2596 N  N   . ILE   A 1 369 ? 7.422   -18.233 -31.689 1.00 44.53  ? 632  ILE   A N   1 
ATOM   2597 C  CA  . ILE   A 1 369 ? 6.174   -17.878 -30.952 1.00 46.63  ? 632  ILE   A CA  1 
ATOM   2598 C  C   . ILE   A 1 369 ? 6.293   -16.444 -30.423 1.00 47.02  ? 632  ILE   A C   1 
ATOM   2599 O  O   . ILE   A 1 369 ? 5.319   -15.933 -29.817 1.00 42.35  ? 632  ILE   A O   1 
ATOM   2600 C  CB  . ILE   A 1 369 ? 5.934   -18.874 -29.800 1.00 46.23  ? 632  ILE   A CB  1 
ATOM   2601 C  CG1 . ILE   A 1 369 ? 7.097   -18.895 -28.813 1.00 43.22  ? 632  ILE   A CG1 1 
ATOM   2602 C  CG2 . ILE   A 1 369 ? 5.615   -20.256 -30.348 1.00 46.89  ? 632  ILE   A CG2 1 
ATOM   2603 C  CD1 . ILE   A 1 369 ? 6.778   -19.580 -27.535 1.00 46.11  ? 632  ILE   A CD1 1 
ATOM   2604 N  N   . GLN   A 1 370 ? 7.475   -15.839 -30.554 1.00 53.30  ? 633  GLN   A N   1 
ATOM   2605 C  CA  . GLN   A 1 370 ? 7.740   -14.510 -29.947 1.00 56.99  ? 633  GLN   A CA  1 
ATOM   2606 C  C   . GLN   A 1 370 ? 6.848   -13.513 -30.683 1.00 49.32  ? 633  GLN   A C   1 
ATOM   2607 O  O   . GLN   A 1 370 ? 6.218   -12.678 -30.032 1.00 49.55  ? 633  GLN   A O   1 
ATOM   2608 C  CB  . GLN   A 1 370 ? 9.233   -14.165 -30.000 1.00 57.93  ? 633  GLN   A CB  1 
ATOM   2609 C  CG  . GLN   A 1 370 ? 9.800   -13.806 -28.629 1.00 70.01  ? 633  GLN   A CG  1 
ATOM   2610 C  CD  . GLN   A 1 370 ? 9.810   -14.959 -27.651 1.00 72.74  ? 633  GLN   A CD  1 
ATOM   2611 O  OE1 . GLN   A 1 370 ? 9.980   -16.114 -28.031 1.00 86.27  ? 633  GLN   A OE1 1 
ATOM   2612 N  NE2 . GLN   A 1 370 ? 9.648   -14.661 -26.371 1.00 72.46  ? 633  GLN   A NE2 1 
ATOM   2613 N  N   . HIS   A 1 371 ? 6.743   -13.684 -31.997 1.00 51.94  ? 634  HIS   A N   1 
ATOM   2614 C  CA  . HIS   A 1 371 ? 6.065   -12.743 -32.910 1.00 56.22  ? 634  HIS   A CA  1 
ATOM   2615 C  C   . HIS   A 1 371 ? 5.880   -13.449 -34.255 1.00 58.12  ? 634  HIS   A C   1 
ATOM   2616 O  O   . HIS   A 1 371 ? 6.848   -14.134 -34.738 1.00 50.20  ? 634  HIS   A O   1 
ATOM   2617 C  CB  . HIS   A 1 371 ? 6.906   -11.443 -32.975 1.00 71.04  ? 634  HIS   A CB  1 
ATOM   2618 C  CG  . HIS   A 1 371 ? 6.651   -10.575 -34.161 1.00 81.87  ? 634  HIS   A CG  1 
ATOM   2619 N  ND1 . HIS   A 1 371 ? 5.647   -9.609  -34.173 1.00 91.30  ? 634  HIS   A ND1 1 
ATOM   2620 C  CD2 . HIS   A 1 371 ? 7.271   -10.500 -35.364 1.00 89.89  ? 634  HIS   A CD2 1 
ATOM   2621 C  CE1 . HIS   A 1 371 ? 5.657   -8.985  -35.340 1.00 97.11  ? 634  HIS   A CE1 1 
ATOM   2622 N  NE2 . HIS   A 1 371 ? 6.644   -9.515  -36.093 1.00 92.65  ? 634  HIS   A NE2 1 
ATOM   2623 N  N   . LEU   A 1 372 ? 4.662   -13.329 -34.788 1.00 58.68  ? 635  LEU   A N   1 
ATOM   2624 C  CA  . LEU   A 1 372 ? 4.276   -13.692 -36.171 1.00 63.60  ? 635  LEU   A CA  1 
ATOM   2625 C  C   . LEU   A 1 372 ? 4.493   -12.453 -37.035 1.00 66.08  ? 635  LEU   A C   1 
ATOM   2626 O  O   . LEU   A 1 372 ? 3.945   -11.402 -36.691 1.00 70.60  ? 635  LEU   A O   1 
ATOM   2627 C  CB  . LEU   A 1 372 ? 2.806   -14.135 -36.210 1.00 61.16  ? 635  LEU   A CB  1 
ATOM   2628 C  CG  . LEU   A 1 372 ? 2.552   -15.560 -36.680 1.00 64.31  ? 635  LEU   A CG  1 
ATOM   2629 C  CD1 . LEU   A 1 372 ? 3.338   -16.553 -35.844 1.00 60.93  ? 635  LEU   A CD1 1 
ATOM   2630 C  CD2 . LEU   A 1 372 ? 1.062   -15.866 -36.637 1.00 62.19  ? 635  LEU   A CD2 1 
ATOM   2631 N  N   . THR   A 1 373 ? 5.266   -12.596 -38.104 1.00 64.49  ? 636  THR   A N   1 
ATOM   2632 C  CA  . THR   A 1 373 ? 5.454   -11.559 -39.136 1.00 60.08  ? 636  THR   A CA  1 
ATOM   2633 C  C   . THR   A 1 373 ? 4.151   -11.499 -39.922 1.00 68.64  ? 636  THR   A C   1 
ATOM   2634 O  O   . THR   A 1 373 ? 3.288   -12.394 -39.721 1.00 71.26  ? 636  THR   A O   1 
ATOM   2635 C  CB  . THR   A 1 373 ? 6.702   -11.849 -39.973 1.00 57.35  ? 636  THR   A CB  1 
ATOM   2636 O  OG1 . THR   A 1 373 ? 6.426   -12.935 -40.861 1.00 62.10  ? 636  THR   A OG1 1 
ATOM   2637 C  CG2 . THR   A 1 373 ? 7.916   -12.148 -39.118 1.00 53.72  ? 636  THR   A CG2 1 
ATOM   2638 N  N   . VAL   A 1 374 ? 4.000   -10.486 -40.766 1.00 61.07  ? 637  VAL   A N   1 
ATOM   2639 C  CA  . VAL   A 1 374 ? 2.762   -10.274 -41.568 1.00 65.17  ? 637  VAL   A CA  1 
ATOM   2640 C  C   . VAL   A 1 374 ? 2.565   -11.458 -42.535 1.00 64.12  ? 637  VAL   A C   1 
ATOM   2641 O  O   . VAL   A 1 374 ? 1.407   -11.897 -42.730 1.00 63.29  ? 637  VAL   A O   1 
ATOM   2642 C  CB  . VAL   A 1 374 ? 2.793   -8.922  -42.321 1.00 74.42  ? 637  VAL   A CB  1 
ATOM   2643 C  CG1 . VAL   A 1 374 ? 2.793   -7.742  -41.363 1.00 76.75  ? 637  VAL   A CG1 1 
ATOM   2644 C  CG2 . VAL   A 1 374 ? 3.955   -8.811  -43.305 1.00 70.26  ? 637  VAL   A CG2 1 
ATOM   2645 N  N   . THR   A 1 375 ? 3.667   -11.943 -43.119 0.50 60.56  ? 638  THR   A N   1 
ATOM   2646 C  CA  . THR   A 1 375 ? 3.695   -12.997 -44.167 0.50 61.61  ? 638  THR   A CA  1 
ATOM   2647 C  C   . THR   A 1 375 ? 3.388   -14.362 -43.536 0.50 57.62  ? 638  THR   A C   1 
ATOM   2648 O  O   . THR   A 1 375 ? 2.665   -15.147 -44.174 0.50 57.31  ? 638  THR   A O   1 
ATOM   2649 C  CB  . THR   A 1 375 ? 5.043   -12.991 -44.898 0.50 62.60  ? 638  THR   A CB  1 
ATOM   2650 O  OG1 . THR   A 1 375 ? 6.052   -13.301 -43.937 0.50 67.65  ? 638  THR   A OG1 1 
ATOM   2651 C  CG2 . THR   A 1 375 ? 5.351   -11.664 -45.558 0.50 64.10  ? 638  THR   A CG2 1 
ATOM   2652 N  N   . GLU   A 1 376 ? 3.934   -14.632 -42.345 0.50 56.08  ? 639  GLU   A N   1 
ATOM   2653 C  CA  . GLU   A 1 376 ? 3.649   -15.863 -41.557 0.50 55.97  ? 639  GLU   A CA  1 
ATOM   2654 C  C   . GLU   A 1 376 ? 2.131   -15.960 -41.365 0.50 52.57  ? 639  GLU   A C   1 
ATOM   2655 O  O   . GLU   A 1 376 ? 1.553   -16.979 -41.773 0.50 48.10  ? 639  GLU   A O   1 
ATOM   2656 C  CB  . GLU   A 1 376 ? 4.402   -15.849 -40.224 0.50 54.99  ? 639  GLU   A CB  1 
ATOM   2657 C  CG  . GLU   A 1 376 ? 5.840   -16.342 -40.325 0.50 55.04  ? 639  GLU   A CG  1 
ATOM   2658 C  CD  . GLU   A 1 376 ? 6.690   -16.078 -39.091 0.50 53.57  ? 639  GLU   A CD  1 
ATOM   2659 O  OE1 . GLU   A 1 376 ? 7.583   -16.898 -38.791 0.50 51.27  ? 639  GLU   A OE1 1 
ATOM   2660 O  OE2 . GLU   A 1 376 ? 6.456   -15.049 -38.428 0.50 56.34  ? 639  GLU   A OE2 1 
ATOM   2661 N  N   . GLU   A 1 377 ? 1.506   -14.920 -40.805 0.50 54.73  ? 640  GLU   A N   1 
ATOM   2662 C  CA  . GLU   A 1 377 ? 0.033   -14.862 -40.604 0.50 53.03  ? 640  GLU   A CA  1 
ATOM   2663 C  C   . GLU   A 1 377 ? -0.646  -15.437 -41.849 0.50 52.96  ? 640  GLU   A C   1 
ATOM   2664 O  O   . GLU   A 1 377 ? -1.380  -16.427 -41.725 0.50 52.28  ? 640  GLU   A O   1 
ATOM   2665 C  CB  . GLU   A 1 377 ? -0.426  -13.430 -40.325 0.50 53.03  ? 640  GLU   A CB  1 
ATOM   2666 C  CG  . GLU   A 1 377 ? -0.092  -12.953 -38.924 0.50 53.64  ? 640  GLU   A CG  1 
ATOM   2667 C  CD  . GLU   A 1 377 ? -0.490  -11.515 -38.634 0.50 54.56  ? 640  GLU   A CD  1 
ATOM   2668 O  OE1 . GLU   A 1 377 ? -1.364  -10.993 -39.353 0.50 55.09  ? 640  GLU   A OE1 1 
ATOM   2669 O  OE2 . GLU   A 1 377 ? 0.078   -10.921 -37.691 0.50 54.85  ? 640  GLU   A OE2 1 
ATOM   2670 N  N   . ILE   A 1 378 ? -0.381  -14.848 -43.015 0.50 54.13  ? 641  ILE   A N   1 
ATOM   2671 C  CA  . ILE   A 1 378 ? -0.980  -15.260 -44.319 0.50 53.44  ? 641  ILE   A CA  1 
ATOM   2672 C  C   . ILE   A 1 378 ? -0.650  -16.738 -44.586 0.50 51.10  ? 641  ILE   A C   1 
ATOM   2673 O  O   . ILE   A 1 378 ? -1.532  -17.454 -45.097 0.50 51.13  ? 641  ILE   A O   1 
ATOM   2674 C  CB  . ILE   A 1 378 ? -0.492  -14.326 -45.447 0.50 54.84  ? 641  ILE   A CB  1 
ATOM   2675 C  CG1 . ILE   A 1 378 ? -0.920  -14.816 -46.832 0.50 56.69  ? 641  ILE   A CG1 1 
ATOM   2676 C  CG2 . ILE   A 1 378 ? 1.014   -14.137 -45.368 0.50 57.54  ? 641  ILE   A CG2 1 
ATOM   2677 C  CD1 . ILE   A 1 378 ? 0.119   -15.668 -47.523 0.50 59.24  ? 641  ILE   A CD1 1 
ATOM   2678 N  N   . ALA   A 1 379 ? 0.574   -17.173 -44.268 1.00 47.07  ? 642  ALA   A N   1 
ATOM   2679 C  CA  . ALA   A 1 379 ? 1.015   -18.578 -44.427 1.00 47.36  ? 642  ALA   A CA  1 
ATOM   2680 C  C   . ALA   A 1 379 ? 0.196   -19.509 -43.491 1.00 37.20  ? 642  ALA   A C   1 
ATOM   2681 O  O   . ALA   A 1 379 ? -0.213  -20.578 -43.956 1.00 38.14  ? 642  ALA   A O   1 
ATOM   2682 C  CB  . ALA   A 1 379 ? 2.499   -18.680 -44.164 1.00 47.94  ? 642  ALA   A CB  1 
ATOM   2683 N  N   . VAL   A 1 380 ? -0.041  -19.076 -42.258 1.00 35.74  ? 643  VAL   A N   1 
ATOM   2684 C  CA  . VAL   A 1 380 ? -0.878  -19.793 -41.255 1.00 44.20  ? 643  VAL   A CA  1 
ATOM   2685 C  C   . VAL   A 1 380 ? -2.320  -19.882 -41.780 1.00 45.86  ? 643  VAL   A C   1 
ATOM   2686 O  O   . VAL   A 1 380 ? -2.903  -20.992 -41.779 1.00 38.64  ? 643  VAL   A O   1 
ATOM   2687 C  CB  . VAL   A 1 380 ? -0.776  -19.205 -39.835 1.00 41.56  ? 643  VAL   A CB  1 
ATOM   2688 C  CG1 . VAL   A 1 380 ? -1.822  -19.823 -38.922 1.00 45.51  ? 643  VAL   A CG1 1 
ATOM   2689 C  CG2 . VAL   A 1 380 ? 0.601   -19.436 -39.215 1.00 42.69  ? 643  VAL   A CG2 1 
ATOM   2690 N  N   . LYS   A 1 381 ? -2.877  -18.771 -42.274 0.50 44.49  ? 644  LYS   A N   1 
ATOM   2691 C  CA  . LYS   A 1 381 ? -4.253  -18.747 -42.840 0.50 45.13  ? 644  LYS   A CA  1 
ATOM   2692 C  C   . LYS   A 1 381 ? -4.312  -19.680 -44.057 0.50 43.11  ? 644  LYS   A C   1 
ATOM   2693 O  O   . LYS   A 1 381 ? -5.275  -20.476 -44.159 0.50 40.56  ? 644  LYS   A O   1 
ATOM   2694 C  CB  . LYS   A 1 381 ? -4.660  -17.316 -43.206 0.50 50.37  ? 644  LYS   A CB  1 
ATOM   2695 C  CG  . LYS   A 1 381 ? -4.767  -16.358 -42.028 0.50 51.92  ? 644  LYS   A CG  1 
ATOM   2696 C  CD  . LYS   A 1 381 ? -5.142  -14.940 -42.420 0.50 54.30  ? 644  LYS   A CD  1 
ATOM   2697 C  CE  . LYS   A 1 381 ? -5.308  -14.018 -41.229 0.50 53.69  ? 644  LYS   A CE  1 
ATOM   2698 N  NZ  . LYS   A 1 381 ? -4.023  -13.763 -40.538 0.50 53.59  ? 644  LYS   A NZ  1 
ATOM   2699 N  N   . ASN   A 1 382 ? -3.305  -19.602 -44.931 0.50 40.32  ? 645  ASN   A N   1 
ATOM   2700 C  CA  . ASN   A 1 382 ? -3.227  -20.379 -46.199 0.50 41.11  ? 645  ASN   A CA  1 
ATOM   2701 C  C   . ASN   A 1 382 ? -3.090  -21.879 -45.882 0.50 37.24  ? 645  ASN   A C   1 
ATOM   2702 O  O   . ASN   A 1 382 ? -3.661  -22.687 -46.628 0.50 37.53  ? 645  ASN   A O   1 
ATOM   2703 C  CB  . ASN   A 1 382 ? -2.095  -19.866 -47.100 0.50 42.98  ? 645  ASN   A CB  1 
ATOM   2704 C  CG  . ASN   A 1 382 ? -2.419  -18.555 -47.793 0.50 43.30  ? 645  ASN   A CG  1 
ATOM   2705 O  OD1 . ASN   A 1 382 ? -3.568  -18.124 -47.827 0.50 42.34  ? 645  ASN   A OD1 1 
ATOM   2706 N  ND2 . ASN   A 1 382 ? -1.413  -17.921 -48.375 0.50 44.56  ? 645  ASN   A ND2 1 
ATOM   2707 N  N   . TRP   A 1 383 ? -2.342  -22.240 -44.832 1.00 39.10  ? 646  TRP   A N   1 
ATOM   2708 C  CA  . TRP   A 1 383 ? -2.192  -23.668 -44.377 1.00 35.72  ? 646  TRP   A CA  1 
ATOM   2709 C  C   . TRP   A 1 383 ? -3.577  -24.214 -43.946 1.00 30.33  ? 646  TRP   A C   1 
ATOM   2710 O  O   . TRP   A 1 383 ? -4.038  -25.262 -44.489 1.00 32.36  ? 646  TRP   A O   1 
ATOM   2711 C  CB  . TRP   A 1 383 ? -1.145  -23.717 -43.248 1.00 33.71  ? 646  TRP   A CB  1 
ATOM   2712 C  CG  . TRP   A 1 383 ? -0.721  -25.077 -42.773 1.00 38.90  ? 646  TRP   A CG  1 
ATOM   2713 C  CD1 . TRP   A 1 383 ? 0.280   -25.877 -43.263 1.00 39.05  ? 646  TRP   A CD1 1 
ATOM   2714 C  CD2 . TRP   A 1 383 ? -1.290  -25.795 -41.668 1.00 34.30  ? 646  TRP   A CD2 1 
ATOM   2715 N  NE1 . TRP   A 1 383 ? 0.382   -27.034 -42.533 1.00 36.61  ? 646  TRP   A NE1 1 
ATOM   2716 C  CE2 . TRP   A 1 383 ? -0.566  -27.007 -41.541 1.00 35.91  ? 646  TRP   A CE2 1 
ATOM   2717 C  CE3 . TRP   A 1 383 ? -2.343  -25.526 -40.794 1.00 32.10  ? 646  TRP   A CE3 1 
ATOM   2718 C  CZ2 . TRP   A 1 383 ? -0.870  -27.940 -40.550 1.00 32.88  ? 646  TRP   A CZ2 1 
ATOM   2719 C  CZ3 . TRP   A 1 383 ? -2.645  -26.449 -39.812 1.00 34.60  ? 646  TRP   A CZ3 1 
ATOM   2720 C  CH2 . TRP   A 1 383 ? -1.913  -27.633 -39.694 1.00 31.27  ? 646  TRP   A CH2 1 
ATOM   2721 N  N   . LEU   A 1 384 ? -4.281  -23.432 -43.132 1.00 34.17  ? 647  LEU   A N   1 
ATOM   2722 C  CA  . LEU   A 1 384 ? -5.638  -23.798 -42.621 1.00 38.37  ? 647  LEU   A CA  1 
ATOM   2723 C  C   . LEU   A 1 384 ? -6.600  -24.032 -43.787 1.00 39.53  ? 647  LEU   A C   1 
ATOM   2724 O  O   . LEU   A 1 384 ? -7.212  -25.124 -43.827 1.00 36.00  ? 647  LEU   A O   1 
ATOM   2725 C  CB  . LEU   A 1 384 ? -6.138  -22.736 -41.644 1.00 34.37  ? 647  LEU   A CB  1 
ATOM   2726 C  CG  . LEU   A 1 384 ? -5.443  -22.737 -40.285 1.00 33.81  ? 647  LEU   A CG  1 
ATOM   2727 C  CD1 . LEU   A 1 384 ? -5.872  -21.557 -39.461 1.00 34.85  ? 647  LEU   A CD1 1 
ATOM   2728 C  CD2 . LEU   A 1 384 ? -5.712  -24.028 -39.496 1.00 35.48  ? 647  LEU   A CD2 1 
ATOM   2729 N  N   . VAL   A 1 385 ? -6.693  -23.097 -44.738 1.00 39.48  ? 648  VAL   A N   1 
ATOM   2730 C  CA  . VAL   A 1 385 ? -7.600  -23.204 -45.915 1.00 38.95  ? 648  VAL   A CA  1 
ATOM   2731 C  C   . VAL   A 1 385 ? -7.196  -24.403 -46.779 1.00 37.92  ? 648  VAL   A C   1 
ATOM   2732 O  O   . VAL   A 1 385 ? -8.068  -25.146 -47.200 1.00 41.29  ? 648  VAL   A O   1 
ATOM   2733 C  CB  . VAL   A 1 385 ? -7.625  -21.889 -46.727 1.00 47.33  ? 648  VAL   A CB  1 
ATOM   2734 C  CG1 . VAL   A 1 385 ? -8.308  -22.054 -48.071 1.00 48.85  ? 648  VAL   A CG1 1 
ATOM   2735 C  CG2 . VAL   A 1 385 ? -8.296  -20.777 -45.932 1.00 51.59  ? 648  VAL   A CG2 1 
ATOM   2736 N  N   . ARG   A 1 386 ? -5.893  -24.585 -47.016 0.50 39.03  ? 649  ARG   A N   1 
ATOM   2737 C  CA  . ARG   A 1 386 ? -5.351  -25.625 -47.933 0.50 40.35  ? 649  ARG   A CA  1 
ATOM   2738 C  C   . ARG   A 1 386 ? -5.446  -27.021 -47.293 0.50 40.59  ? 649  ARG   A C   1 
ATOM   2739 O  O   . ARG   A 1 386 ? -5.971  -27.940 -47.962 0.50 40.18  ? 649  ARG   A O   1 
ATOM   2740 C  CB  . ARG   A 1 386 ? -3.905  -25.284 -48.307 0.50 45.27  ? 649  ARG   A CB  1 
ATOM   2741 C  CG  . ARG   A 1 386 ? -3.249  -26.291 -49.244 0.50 50.18  ? 649  ARG   A CG  1 
ATOM   2742 C  CD  . ARG   A 1 386 ? -1.846  -25.891 -49.695 0.50 52.81  ? 649  ARG   A CD  1 
ATOM   2743 N  NE  . ARG   A 1 386 ? -0.821  -26.013 -48.658 0.50 54.46  ? 649  ARG   A NE  1 
ATOM   2744 C  CZ  . ARG   A 1 386 ? -0.385  -25.006 -47.901 0.50 53.17  ? 649  ARG   A CZ  1 
ATOM   2745 N  NH1 . ARG   A 1 386 ? -0.885  -23.792 -48.056 0.50 53.58  ? 649  ARG   A NH1 1 
ATOM   2746 N  NH2 . ARG   A 1 386 ? 0.554   -25.217 -46.995 0.50 52.34  ? 649  ARG   A NH2 1 
ATOM   2747 N  N   . VAL   A 1 387 ? -4.946  -27.192 -46.062 1.00 38.73  ? 650  VAL   A N   1 
ATOM   2748 C  CA  . VAL   A 1 387 ? -4.827  -28.563 -45.454 1.00 37.76  ? 650  VAL   A CA  1 
ATOM   2749 C  C   . VAL   A 1 387 ? -5.525  -28.730 -44.092 1.00 34.75  ? 650  VAL   A C   1 
ATOM   2750 O  O   . VAL   A 1 387 ? -5.436  -29.865 -43.573 1.00 33.34  ? 650  VAL   A O   1 
ATOM   2751 C  CB  . VAL   A 1 387 ? -3.342  -28.978 -45.352 1.00 33.64  ? 650  VAL   A CB  1 
ATOM   2752 C  CG1 . VAL   A 1 387 ? -2.672  -29.022 -46.724 1.00 39.67  ? 650  VAL   A CG1 1 
ATOM   2753 C  CG2 . VAL   A 1 387 ? -2.585  -28.098 -44.370 1.00 35.32  ? 650  VAL   A CG2 1 
ATOM   2754 N  N   . GLY   A 1 388 ? -6.128  -27.682 -43.523 1.00 32.64  ? 651  GLY   A N   1 
ATOM   2755 C  CA  . GLY   A 1 388 ? -6.717  -27.681 -42.165 1.00 33.70  ? 651  GLY   A CA  1 
ATOM   2756 C  C   . GLY   A 1 388 ? -7.630  -28.885 -41.950 1.00 32.52  ? 651  GLY   A C   1 
ATOM   2757 O  O   . GLY   A 1 388 ? -7.454  -29.615 -40.946 1.00 32.56  ? 651  GLY   A O   1 
ATOM   2758 N  N   . ARG   A 1 389 ? -8.536  -29.143 -42.879 1.00 30.71  ? 652  ARG   A N   1 
ATOM   2759 C  CA  . ARG   A 1 389 ? -9.518  -30.251 -42.733 1.00 33.07  ? 652  ARG   A CA  1 
ATOM   2760 C  C   . ARG   A 1 389 ? -8.786  -31.604 -42.734 1.00 32.02  ? 652  ARG   A C   1 
ATOM   2761 O  O   . ARG   A 1 389 ? -9.162  -32.504 -41.941 1.00 29.93  ? 652  ARG   A O   1 
ATOM   2762 C  CB  . ARG   A 1 389 ? -10.631 -30.119 -43.772 1.00 33.93  ? 652  ARG   A CB  1 
ATOM   2763 C  CG  . ARG   A 1 389 ? -11.578 -28.964 -43.469 1.00 35.23  ? 652  ARG   A CG  1 
ATOM   2764 C  CD  . ARG   A 1 389 ? -12.672 -28.876 -44.525 1.00 39.89  ? 652  ARG   A CD  1 
ATOM   2765 N  NE  . ARG   A 1 389 ? -13.601 -29.983 -44.463 1.00 38.92  ? 652  ARG   A NE  1 
ATOM   2766 C  CZ  . ARG   A 1 389 ? -14.669 -30.055 -43.641 1.00 38.24  ? 652  ARG   A CZ  1 
ATOM   2767 N  NH1 . ARG   A 1 389 ? -14.979 -29.067 -42.820 1.00 42.26  ? 652  ARG   A NH1 1 
ATOM   2768 N  NH2 . ARG   A 1 389 ? -15.428 -31.136 -43.659 1.00 43.04  ? 652  ARG   A NH2 1 
ATOM   2769 N  N   . GLU   A 1 390 ? -7.762  -31.752 -43.579 0.50 31.00  ? 653  GLU   A N   1 
ATOM   2770 C  CA  . GLU   A 1 390 ? -6.962  -33.002 -43.658 0.50 32.20  ? 653  GLU   A CA  1 
ATOM   2771 C  C   . GLU   A 1 390 ? -6.242  -33.214 -42.315 0.50 28.76  ? 653  GLU   A C   1 
ATOM   2772 O  O   . GLU   A 1 390 ? -6.238  -34.378 -41.834 0.50 29.83  ? 653  GLU   A O   1 
ATOM   2773 C  CB  . GLU   A 1 390 ? -6.014  -32.965 -44.862 0.50 32.40  ? 653  GLU   A CB  1 
ATOM   2774 C  CG  . GLU   A 1 390 ? -5.352  -34.297 -45.153 0.50 33.22  ? 653  GLU   A CG  1 
ATOM   2775 C  CD  . GLU   A 1 390 ? -4.201  -34.647 -44.223 0.50 33.67  ? 653  GLU   A CD  1 
ATOM   2776 O  OE1 . GLU   A 1 390 ? -3.911  -33.838 -43.313 0.50 33.45  ? 653  GLU   A OE1 1 
ATOM   2777 O  OE2 . GLU   A 1 390 ? -3.592  -35.724 -44.412 0.50 34.23  ? 653  GLU   A OE2 1 
ATOM   2778 N  N   . ARG   A 1 391 ? -5.703  -32.136 -41.725 1.00 27.91  ? 654  ARG   A N   1 
ATOM   2779 C  CA  . ARG   A 1 391 ? -4.926  -32.193 -40.453 1.00 28.65  ? 654  ARG   A CA  1 
ATOM   2780 C  C   . ARG   A 1 391 ? -5.880  -32.494 -39.278 1.00 28.74  ? 654  ARG   A C   1 
ATOM   2781 O  O   . ARG   A 1 391 ? -5.469  -33.219 -38.347 1.00 25.34  ? 654  ARG   A O   1 
ATOM   2782 C  CB  . ARG   A 1 391 ? -4.093  -30.919 -40.260 1.00 30.15  ? 654  ARG   A CB  1 
ATOM   2783 C  CG  . ARG   A 1 391 ? -3.062  -30.689 -41.362 1.00 31.15  ? 654  ARG   A CG  1 
ATOM   2784 C  CD  . ARG   A 1 391 ? -2.034  -31.809 -41.459 1.00 35.41  ? 654  ARG   A CD  1 
ATOM   2785 N  NE  . ARG   A 1 391 ? -0.941  -31.392 -42.311 1.00 33.05  ? 654  ARG   A NE  1 
ATOM   2786 C  CZ  . ARG   A 1 391 ? -0.903  -31.542 -43.632 1.00 38.85  ? 654  ARG   A CZ  1 
ATOM   2787 N  NH1 . ARG   A 1 391 ? -1.859  -32.163 -44.306 1.00 37.31  ? 654  ARG   A NH1 1 
ATOM   2788 N  NH2 . ARG   A 1 391 ? 0.125   -31.062 -44.302 1.00 44.67  ? 654  ARG   A NH2 1 
ATOM   2789 N  N   . LEU   A 1 392 ? -7.134  -32.038 -39.339 1.00 26.29  ? 655  LEU   A N   1 
ATOM   2790 C  CA  . LEU   A 1 392 ? -8.155  -32.379 -38.298 1.00 25.96  ? 655  LEU   A CA  1 
ATOM   2791 C  C   . LEU   A 1 392 ? -8.443  -33.887 -38.337 1.00 28.29  ? 655  LEU   A C   1 
ATOM   2792 O  O   . LEU   A 1 392 ? -8.560  -34.524 -37.274 1.00 28.27  ? 655  LEU   A O   1 
ATOM   2793 C  CB  . LEU   A 1 392 ? -9.450  -31.584 -38.504 1.00 30.22  ? 655  LEU   A CB  1 
ATOM   2794 C  CG  . LEU   A 1 392 ? -9.429  -30.095 -38.173 1.00 27.63  ? 655  LEU   A CG  1 
ATOM   2795 C  CD1 . LEU   A 1 392 ? -10.776 -29.503 -38.570 1.00 28.59  ? 655  LEU   A CD1 1 
ATOM   2796 C  CD2 . LEU   A 1 392 ? -9.118  -29.834 -36.695 1.00 27.48  ? 655  LEU   A CD2 1 
ATOM   2797 N  N   . SER   A 1 393 ? -8.524  -34.442 -39.544 0.50 28.56  ? 656  SER   A N   1 
ATOM   2798 C  CA  . SER   A 1 393 ? -8.827  -35.870 -39.810 0.50 28.81  ? 656  SER   A CA  1 
ATOM   2799 C  C   . SER   A 1 393 ? -7.724  -36.771 -39.242 0.50 27.01  ? 656  SER   A C   1 
ATOM   2800 O  O   . SER   A 1 393 ? -7.988  -37.955 -39.055 0.50 26.46  ? 656  SER   A O   1 
ATOM   2801 C  CB  . SER   A 1 393 ? -9.045  -36.098 -41.286 0.50 31.17  ? 656  SER   A CB  1 
ATOM   2802 O  OG  . SER   A 1 393 ? -7.846  -35.876 -42.028 0.50 32.90  ? 656  SER   A OG  1 
ATOM   2803 N  N   . ARG   A 1 394 ? -6.545  -36.219 -38.936 1.00 26.35  ? 657  ARG   A N   1 
ATOM   2804 C  CA  . ARG   A 1 394 ? -5.384  -37.005 -38.442 1.00 25.27  ? 657  ARG   A CA  1 
ATOM   2805 C  C   . ARG   A 1 394 ? -5.467  -37.110 -36.928 1.00 24.18  ? 657  ARG   A C   1 
ATOM   2806 O  O   . ARG   A 1 394 ? -4.501  -37.580 -36.295 1.00 24.84  ? 657  ARG   A O   1 
ATOM   2807 C  CB  . ARG   A 1 394 ? -4.054  -36.319 -38.790 1.00 27.69  ? 657  ARG   A CB  1 
ATOM   2808 C  CG  . ARG   A 1 394 ? -3.690  -36.336 -40.259 1.00 28.75  ? 657  ARG   A CG  1 
ATOM   2809 C  CD  . ARG   A 1 394 ? -2.440  -35.474 -40.506 1.00 28.64  ? 657  ARG   A CD  1 
ATOM   2810 N  NE  . ARG   A 1 394 ? -2.036  -35.875 -41.836 1.00 27.15  ? 657  ARG   A NE  1 
ATOM   2811 C  CZ  . ARG   A 1 394 ? -1.320  -36.919 -42.135 1.00 31.39  ? 657  ARG   A CZ  1 
ATOM   2812 N  NH1 . ARG   A 1 394 ? -0.701  -37.608 -41.182 1.00 31.01  ? 657  ARG   A NH1 1 
ATOM   2813 N  NH2 . ARG   A 1 394 ? -1.187  -37.240 -43.416 1.00 31.34  ? 657  ARG   A NH2 1 
ATOM   2814 N  N   . MET   A 1 395 ? -6.550  -36.627 -36.332 1.00 22.47  ? 658  MET   A N   1 
ATOM   2815 C  CA  . MET   A 1 395 ? -6.704  -36.593 -34.864 1.00 23.34  ? 658  MET   A CA  1 
ATOM   2816 C  C   . MET   A 1 395 ? -8.018  -37.267 -34.408 1.00 23.90  ? 658  MET   A C   1 
ATOM   2817 O  O   . MET   A 1 395 ? -9.028  -37.223 -35.126 1.00 21.44  ? 658  MET   A O   1 
ATOM   2818 C  CB  . MET   A 1 395 ? -6.619  -35.158 -34.369 1.00 23.65  ? 658  MET   A CB  1 
ATOM   2819 C  CG  . MET   A 1 395 ? -5.414  -34.393 -34.942 1.00 26.18  ? 658  MET   A CG  1 
ATOM   2820 S  SD  . MET   A 1 395 ? -5.021  -32.864 -34.105 1.00 25.67  ? 658  MET   A SD  1 
ATOM   2821 C  CE  . MET   A 1 395 ? -6.310  -31.781 -34.728 1.00 25.21  ? 658  MET   A CE  1 
ATOM   2822 N  N   . ALA   A 1 396 ? -7.987  -37.782 -33.179 1.00 22.97  ? 659  ALA   A N   1 
ATOM   2823 C  CA  . ALA   A 1 396 ? -9.144  -38.196 -32.374 1.00 22.43  ? 659  ALA   A CA  1 
ATOM   2824 C  C   . ALA   A 1 396 ? -9.043  -37.481 -31.040 1.00 22.53  ? 659  ALA   A C   1 
ATOM   2825 O  O   . ALA   A 1 396 ? -8.049  -37.650 -30.336 1.00 20.13  ? 659  ALA   A O   1 
ATOM   2826 C  CB  . ALA   A 1 396 ? -9.158  -39.707 -32.244 1.00 22.80  ? 659  ALA   A CB  1 
ATOM   2827 N  N   . ILE   A 1 397 ? -10.003 -36.589 -30.786 1.00 21.15  ? 660  ILE   A N   1 
ATOM   2828 C  CA  . ILE   A 1 397 ? -10.011 -35.674 -29.631 1.00 20.19  ? 660  ILE   A CA  1 
ATOM   2829 C  C   . ILE   A 1 397 ? -11.340 -35.810 -28.883 1.00 23.30  ? 660  ILE   A C   1 
ATOM   2830 O  O   . ILE   A 1 397 ? -12.398 -35.558 -29.427 1.00 21.77  ? 660  ILE   A O   1 
ATOM   2831 C  CB  . ILE   A 1 397 ? -9.697  -34.245 -30.089 1.00 22.85  ? 660  ILE   A CB  1 
ATOM   2832 C  CG1 . ILE   A 1 397 ? -8.356  -34.252 -30.827 1.00 24.93  ? 660  ILE   A CG1 1 
ATOM   2833 C  CG2 . ILE   A 1 397 ? -9.753  -33.281 -28.888 1.00 24.05  ? 660  ILE   A CG2 1 
ATOM   2834 C  CD1 . ILE   A 1 397 ? -7.817  -32.898 -31.291 1.00 27.61  ? 660  ILE   A CD1 1 
ATOM   2835 N  N   . SER   A 1 398 ? -11.219 -36.140 -27.609 1.00 21.63  ? 661  SER   A N   1 
ATOM   2836 C  CA  . SER   A 1 398 ? -12.312 -36.281 -26.639 1.00 24.09  ? 661  SER   A CA  1 
ATOM   2837 C  C   . SER   A 1 398 ? -12.005 -35.395 -25.443 1.00 25.49  ? 661  SER   A C   1 
ATOM   2838 O  O   . SER   A 1 398 ? -11.208 -35.832 -24.580 1.00 24.64  ? 661  SER   A O   1 
ATOM   2839 C  CB  . SER   A 1 398 ? -12.475 -37.714 -26.226 1.00 27.03  ? 661  SER   A CB  1 
ATOM   2840 O  OG  . SER   A 1 398 ? -13.715 -37.829 -25.583 1.00 26.11  ? 661  SER   A OG  1 
ATOM   2841 N  N   . GLY   A 1 399 ? -12.509 -34.154 -25.450 1.00 24.28  ? 662  GLY   A N   1 
ATOM   2842 C  CA  . GLY   A 1 399 ? -12.107 -33.184 -24.403 1.00 25.64  ? 662  GLY   A CA  1 
ATOM   2843 C  C   . GLY   A 1 399 ? -10.594 -33.019 -24.303 1.00 26.33  ? 662  GLY   A C   1 
ATOM   2844 O  O   . GLY   A 1 399 ? -9.949  -32.750 -25.352 1.00 26.84  ? 662  GLY   A O   1 
ATOM   2845 N  N   . ASP   A 1 400 ? -9.999  -33.230 -23.114 1.00 26.59  ? 663  ASP   A N   1 
ATOM   2846 C  CA  . ASP   A 1 400 ? -8.541  -33.060 -22.891 1.00 29.17  ? 663  ASP   A CA  1 
ATOM   2847 C  C   . ASP   A 1 400 ? -7.734  -34.254 -23.435 1.00 28.80  ? 663  ASP   A C   1 
ATOM   2848 O  O   . ASP   A 1 400 ? -6.490  -34.168 -23.429 1.00 26.77  ? 663  ASP   A O   1 
ATOM   2849 C  CB  . ASP   A 1 400 ? -8.266  -32.812 -21.408 1.00 32.87  ? 663  ASP   A CB  1 
ATOM   2850 C  CG  . ASP   A 1 400 ? -8.563  -33.964 -20.454 1.00 36.90  ? 663  ASP   A CG  1 
ATOM   2851 O  OD1 . ASP   A 1 400 ? -9.069  -34.981 -20.866 1.00 37.35  ? 663  ASP   A OD1 1 
ATOM   2852 O  OD2 . ASP   A 1 400 ? -8.224  -33.827 -19.290 1.00 41.65  ? 663  ASP   A OD2 1 
ATOM   2853 N  N   . ASP   A 1 401 ? -8.383  -35.274 -23.971 1.00 26.18  ? 664  ASP   A N   1 
ATOM   2854 C  CA  . ASP   A 1 401 ? -7.734  -36.533 -24.446 1.00 25.36  ? 664  ASP   A CA  1 
ATOM   2855 C  C   . ASP   A 1 401 ? -7.522  -36.465 -25.961 1.00 26.55  ? 664  ASP   A C   1 
ATOM   2856 O  O   . ASP   A 1 401 ? -8.491  -36.105 -26.671 1.00 27.22  ? 664  ASP   A O   1 
ATOM   2857 C  CB  . ASP   A 1 401 ? -8.573  -37.746 -24.028 1.00 27.01  ? 664  ASP   A CB  1 
ATOM   2858 C  CG  . ASP   A 1 401 ? -7.727  -38.994 -23.899 1.00 36.97  ? 664  ASP   A CG  1 
ATOM   2859 O  OD1 . ASP   A 1 401 ? -6.596  -38.861 -24.167 1.00 34.56  ? 664  ASP   A OD1 1 
ATOM   2860 O  OD2 . ASP   A 1 401 ? -8.233  -40.051 -23.582 1.00 36.69  ? 664  ASP   A OD2 1 
ATOM   2861 N  N   . CYS   A 1 402 ? -6.304  -36.676 -26.455 1.00 22.51  ? 665  CYS   A N   1 
ATOM   2862 C  CA  . CYS   A 1 402 ? -6.054  -36.678 -27.914 1.00 24.31  ? 665  CYS   A CA  1 
ATOM   2863 C  C   . CYS   A 1 402 ? -5.166  -37.836 -28.344 1.00 25.22  ? 665  CYS   A C   1 
ATOM   2864 O  O   . CYS   A 1 402 ? -4.310  -38.289 -27.573 1.00 26.54  ? 665  CYS   A O   1 
ATOM   2865 C  CB  . CYS   A 1 402 ? -5.441  -35.381 -28.401 1.00 28.85  ? 665  CYS   A CB  1 
ATOM   2866 S  SG  . CYS   A 1 402 ? -3.822  -35.026 -27.676 1.00 34.89  ? 665  CYS   A SG  1 
ATOM   2867 N  N   . VAL   A 1 403 ? -5.317  -38.169 -29.617 1.00 22.72  ? 666  VAL   A N   1 
ATOM   2868 C  CA  . VAL   A 1 403 ? -4.395  -39.004 -30.430 1.00 24.14  ? 666  VAL   A CA  1 
ATOM   2869 C  C   . VAL   A 1 403 ? -4.186  -38.212 -31.722 1.00 23.64  ? 666  VAL   A C   1 
ATOM   2870 O  O   . VAL   A 1 403 ? -5.197  -37.744 -32.302 1.00 22.32  ? 666  VAL   A O   1 
ATOM   2871 C  CB  . VAL   A 1 403 ? -4.971  -40.401 -30.687 1.00 23.58  ? 666  VAL   A CB  1 
ATOM   2872 C  CG1 . VAL   A 1 403 ? -4.096  -41.236 -31.614 1.00 25.94  ? 666  VAL   A CG1 1 
ATOM   2873 C  CG2 . VAL   A 1 403 ? -5.238  -41.100 -29.349 1.00 25.04  ? 666  VAL   A CG2 1 
ATOM   2874 N  N   . VAL   A 1 404 ? -2.933  -38.070 -32.121 1.00 22.35  ? 667  VAL   A N   1 
ATOM   2875 C  CA  . VAL   A 1 404 ? -2.526  -37.285 -33.322 1.00 23.03  ? 667  VAL   A CA  1 
ATOM   2876 C  C   . VAL   A 1 404 ? -1.563  -38.137 -34.142 1.00 23.79  ? 667  VAL   A C   1 
ATOM   2877 O  O   . VAL   A 1 404 ? -0.587  -38.647 -33.563 1.00 25.40  ? 667  VAL   A O   1 
ATOM   2878 C  CB  . VAL   A 1 404 ? -1.860  -35.938 -32.955 1.00 25.06  ? 667  VAL   A CB  1 
ATOM   2879 C  CG1 . VAL   A 1 404 ? -1.578  -35.123 -34.210 1.00 25.93  ? 667  VAL   A CG1 1 
ATOM   2880 C  CG2 . VAL   A 1 404 ? -2.723  -35.139 -32.012 1.00 26.90  ? 667  VAL   A CG2 1 
ATOM   2881 N  N   . LYS   A 1 405 ? -1.846  -38.318 -35.433 1.00 25.59  ? 668  LYS   A N   1 
ATOM   2882 C  CA  . LYS   A 1 405 ? -0.906  -38.930 -36.410 1.00 25.34  ? 668  LYS   A CA  1 
ATOM   2883 C  C   . LYS   A 1 405 ? -0.430  -37.823 -37.351 1.00 26.80  ? 668  LYS   A C   1 
ATOM   2884 O  O   . LYS   A 1 405 ? -1.023  -37.581 -38.413 1.00 25.92  ? 668  LYS   A O   1 
ATOM   2885 C  CB  . LYS   A 1 405 ? -1.499  -40.080 -37.216 1.00 26.87  ? 668  LYS   A CB  1 
ATOM   2886 C  CG  . LYS   A 1 405 ? -0.398  -40.777 -38.009 1.00 28.65  ? 668  LYS   A CG  1 
ATOM   2887 C  CD  . LYS   A 1 405 ? -0.666  -42.141 -38.560 1.00 32.00  ? 668  LYS   A CD  1 
ATOM   2888 C  CE  . LYS   A 1 405 ? 0.589   -42.556 -39.331 1.00 35.56  ? 668  LYS   A CE  1 
ATOM   2889 N  NZ  . LYS   A 1 405 ? 0.496   -43.931 -39.827 1.00 38.83  ? 668  LYS   A NZ  1 
ATOM   2890 N  N   . PRO   A 1 406 ? 0.646   -37.100 -36.972 1.00 26.60  ? 669  PRO   A N   1 
ATOM   2891 C  CA  . PRO   A 1 406 ? 1.145   -35.976 -37.779 1.00 25.64  ? 669  PRO   A CA  1 
ATOM   2892 C  C   . PRO   A 1 406 ? 1.781   -36.422 -39.094 1.00 26.60  ? 669  PRO   A C   1 
ATOM   2893 O  O   . PRO   A 1 406 ? 2.003   -37.580 -39.331 1.00 26.80  ? 669  PRO   A O   1 
ATOM   2894 C  CB  . PRO   A 1 406 ? 2.135   -35.298 -36.823 1.00 24.35  ? 669  PRO   A CB  1 
ATOM   2895 C  CG  . PRO   A 1 406 ? 2.695   -36.446 -36.037 1.00 24.40  ? 669  PRO   A CG  1 
ATOM   2896 C  CD  . PRO   A 1 406 ? 1.489   -37.333 -35.790 1.00 25.92  ? 669  PRO   A CD  1 
ATOM   2897 N  N   . LEU   A 1 407 ? 2.043   -35.440 -39.951 1.00 30.02  ? 670  LEU   A N   1 
ATOM   2898 C  CA  . LEU   A 1 407 ? 2.672   -35.629 -41.280 1.00 33.48  ? 670  LEU   A CA  1 
ATOM   2899 C  C   . LEU   A 1 407 ? 4.023   -36.367 -41.126 1.00 28.89  ? 670  LEU   A C   1 
ATOM   2900 O  O   . LEU   A 1 407 ? 4.320   -37.196 -41.994 1.00 32.55  ? 670  LEU   A O   1 
ATOM   2901 C  CB  . LEU   A 1 407 ? 2.811   -34.238 -41.917 1.00 32.68  ? 670  LEU   A CB  1 
ATOM   2902 C  CG  . LEU   A 1 407 ? 3.081   -34.219 -43.416 1.00 39.50  ? 670  LEU   A CG  1 
ATOM   2903 C  CD1 . LEU   A 1 407 ? 1.855   -34.691 -44.182 1.00 38.37  ? 670  LEU   A CD1 1 
ATOM   2904 C  CD2 . LEU   A 1 407 ? 3.498   -32.825 -43.848 1.00 41.00  ? 670  LEU   A CD2 1 
ATOM   2905 N  N   . ASP   A 1 408 ? 4.775   -36.136 -40.047 1.00 28.34  ? 671  ASP   A N   1 
ATOM   2906 C  CA  . ASP   A 1 408 ? 6.098   -36.792 -39.824 1.00 32.62  ? 671  ASP   A CA  1 
ATOM   2907 C  C   . ASP   A 1 408 ? 6.465   -36.618 -38.359 1.00 30.03  ? 671  ASP   A C   1 
ATOM   2908 O  O   . ASP   A 1 408 ? 5.720   -35.971 -37.626 1.00 34.39  ? 671  ASP   A O   1 
ATOM   2909 C  CB  . ASP   A 1 408 ? 7.141   -36.258 -40.845 1.00 32.68  ? 671  ASP   A CB  1 
ATOM   2910 C  CG  . ASP   A 1 408 ? 7.236   -34.741 -40.840 1.00 31.68  ? 671  ASP   A CG  1 
ATOM   2911 O  OD1 . ASP   A 1 408 ? 7.531   -34.199 -39.759 1.00 31.53  ? 671  ASP   A OD1 1 
ATOM   2912 O  OD2 . ASP   A 1 408 ? 6.863   -34.102 -41.863 1.00 36.14  ? 671  ASP   A OD2 1 
ATOM   2913 N  N   . ASP   A 1 409 ? 7.628   -37.091 -37.937 1.00 27.91  ? 672  ASP   A N   1 
ATOM   2914 C  CA  . ASP   A 1 409 ? 7.983   -37.110 -36.499 1.00 27.53  ? 672  ASP   A CA  1 
ATOM   2915 C  C   . ASP   A 1 409 ? 8.608   -35.789 -36.027 1.00 30.77  ? 672  ASP   A C   1 
ATOM   2916 O  O   . ASP   A 1 409 ? 8.915   -35.701 -34.828 1.00 28.80  ? 672  ASP   A O   1 
ATOM   2917 C  CB  . ASP   A 1 409 ? 8.790   -38.374 -36.211 1.00 31.64  ? 672  ASP   A CB  1 
ATOM   2918 C  CG  . ASP   A 1 409 ? 7.918   -39.616 -36.279 1.00 36.38  ? 672  ASP   A CG  1 
ATOM   2919 O  OD1 . ASP   A 1 409 ? 6.801   -39.571 -35.691 1.00 34.23  ? 672  ASP   A OD1 1 
ATOM   2920 O  OD2 . ASP   A 1 409 ? 8.348   -40.602 -36.924 1.00 35.41  ? 672  ASP   A OD2 1 
ATOM   2921 N  N   . ARG   A 1 410 ? 8.686   -34.744 -36.852 1.00 30.70  ? 673  ARG   A N   1 
ATOM   2922 C  CA  . ARG   A 1 410 ? 9.130   -33.406 -36.345 1.00 34.38  ? 673  ARG   A CA  1 
ATOM   2923 C  C   . ARG   A 1 410 ? 8.186   -32.935 -35.225 1.00 33.03  ? 673  ARG   A C   1 
ATOM   2924 O  O   . ARG   A 1 410 ? 8.608   -32.203 -34.330 1.00 26.92  ? 673  ARG   A O   1 
ATOM   2925 C  CB  . ARG   A 1 410 ? 9.150   -32.377 -37.481 1.00 39.42  ? 673  ARG   A CB  1 
ATOM   2926 C  CG  . ARG   A 1 410 ? 10.270  -32.544 -38.502 1.00 37.90  ? 673  ARG   A CG  1 
ATOM   2927 C  CD  . ARG   A 1 410 ? 10.126  -31.458 -39.569 1.00 35.74  ? 673  ARG   A CD  1 
ATOM   2928 N  NE  . ARG   A 1 410 ? 8.954   -31.725 -40.400 1.00 33.54  ? 673  ARG   A NE  1 
ATOM   2929 C  CZ  . ARG   A 1 410 ? 8.456   -30.940 -41.354 1.00 36.02  ? 673  ARG   A CZ  1 
ATOM   2930 N  NH1 . ARG   A 1 410 ? 9.027   -29.774 -41.654 1.00 30.22  ? 673  ARG   A NH1 1 
ATOM   2931 N  NH2 . ARG   A 1 410 ? 7.386   -31.357 -42.025 1.00 34.32  ? 673  ARG   A NH2 1 
ATOM   2932 N  N   . PHE   A 1 411 ? 6.916   -33.365 -35.262 1.00 30.04  ? 674  PHE   A N   1 
ATOM   2933 C  CA  . PHE   A 1 411 ? 5.888   -33.090 -34.230 1.00 24.96  ? 674  PHE   A CA  1 
ATOM   2934 C  C   . PHE   A 1 411 ? 6.433   -33.389 -32.834 1.00 23.99  ? 674  PHE   A C   1 
ATOM   2935 O  O   . PHE   A 1 411 ? 6.141   -32.624 -31.924 1.00 27.63  ? 674  PHE   A O   1 
ATOM   2936 C  CB  . PHE   A 1 411 ? 4.636   -33.918 -34.557 1.00 26.65  ? 674  PHE   A CB  1 
ATOM   2937 C  CG  . PHE   A 1 411 ? 3.465   -33.751 -33.615 1.00 27.24  ? 674  PHE   A CG  1 
ATOM   2938 C  CD1 . PHE   A 1 411 ? 3.327   -34.581 -32.507 1.00 26.32  ? 674  PHE   A CD1 1 
ATOM   2939 C  CD2 . PHE   A 1 411 ? 2.427   -32.888 -33.928 1.00 28.66  ? 674  PHE   A CD2 1 
ATOM   2940 C  CE1 . PHE   A 1 411 ? 2.195   -34.491 -31.695 1.00 27.30  ? 674  PHE   A CE1 1 
ATOM   2941 C  CE2 . PHE   A 1 411 ? 1.321   -32.762 -33.086 1.00 26.30  ? 674  PHE   A CE2 1 
ATOM   2942 C  CZ  . PHE   A 1 411 ? 1.217   -33.547 -31.961 1.00 26.59  ? 674  PHE   A CZ  1 
ATOM   2943 N  N   . ALA   A 1 412 ? 7.171   -34.500 -32.648 1.00 26.74  ? 675  ALA   A N   1 
ATOM   2944 C  CA  . ALA   A 1 412 ? 7.646   -34.988 -31.332 1.00 28.15  ? 675  ALA   A CA  1 
ATOM   2945 C  C   . ALA   A 1 412 ? 8.404   -33.897 -30.550 1.00 31.93  ? 675  ALA   A C   1 
ATOM   2946 O  O   . ALA   A 1 412 ? 8.244   -33.795 -29.299 1.00 27.56  ? 675  ALA   A O   1 
ATOM   2947 C  CB  . ALA   A 1 412 ? 8.503   -36.231 -31.563 1.00 29.33  ? 675  ALA   A CB  1 
ATOM   2948 N  N   . SER   A 1 413 ? 9.185   -33.061 -31.243 1.00 29.88  ? 676  SER   A N   1 
ATOM   2949 C  CA  . SER   A 1 413 ? 10.051  -32.040 -30.600 1.00 32.49  ? 676  SER   A CA  1 
ATOM   2950 C  C   . SER   A 1 413 ? 9.505   -30.642 -30.865 1.00 37.01  ? 676  SER   A C   1 
ATOM   2951 O  O   . SER   A 1 413 ? 10.225  -29.683 -30.583 1.00 35.61  ? 676  SER   A O   1 
ATOM   2952 C  CB  . SER   A 1 413 ? 11.524  -32.169 -31.065 1.00 36.77  ? 676  SER   A CB  1 
ATOM   2953 O  OG  . SER   A 1 413 ? 11.579  -32.309 -32.486 1.00 38.30  ? 676  SER   A OG  1 
ATOM   2954 N  N   . ALA   A 1 414 ? 8.284   -30.515 -31.397 1.00 35.90  ? 677  ALA   A N   1 
ATOM   2955 C  CA  . ALA   A 1 414 ? 7.646   -29.203 -31.636 1.00 33.88  ? 677  ALA   A CA  1 
ATOM   2956 C  C   . ALA   A 1 414 ? 6.875   -28.851 -30.370 1.00 35.05  ? 677  ALA   A C   1 
ATOM   2957 O  O   . ALA   A 1 414 ? 5.670   -29.268 -30.279 1.00 33.47  ? 677  ALA   A O   1 
ATOM   2958 C  CB  . ALA   A 1 414 ? 6.771   -29.278 -32.852 1.00 33.36  ? 677  ALA   A CB  1 
ATOM   2959 N  N   . LEU   A 1 415 ? 7.537   -28.202 -29.412 1.00 30.27  ? 678  LEU   A N   1 
ATOM   2960 C  CA  . LEU   A 1 415 ? 7.071   -28.056 -28.005 1.00 32.05  ? 678  LEU   A CA  1 
ATOM   2961 C  C   . LEU   A 1 415 ? 6.893   -26.584 -27.617 1.00 32.26  ? 678  LEU   A C   1 
ATOM   2962 O  O   . LEU   A 1 415 ? 6.299   -26.338 -26.559 1.00 34.86  ? 678  LEU   A O   1 
ATOM   2963 C  CB  . LEU   A 1 415 ? 8.031   -28.780 -27.059 1.00 31.75  ? 678  LEU   A CB  1 
ATOM   2964 C  CG  . LEU   A 1 415 ? 8.152   -30.303 -27.258 1.00 33.21  ? 678  LEU   A CG  1 
ATOM   2965 C  CD1 . LEU   A 1 415 ? 9.304   -30.905 -26.470 1.00 36.67  ? 678  LEU   A CD1 1 
ATOM   2966 C  CD2 . LEU   A 1 415 ? 6.853   -31.011 -26.879 1.00 33.69  ? 678  LEU   A CD2 1 
ATOM   2967 N  N   . THR   A 1 416 ? 7.355   -25.616 -28.399 1.00 33.45  ? 679  THR   A N   1 
ATOM   2968 C  CA  . THR   A 1 416 ? 7.371   -24.203 -27.914 1.00 33.36  ? 679  THR   A CA  1 
ATOM   2969 C  C   . THR   A 1 416 ? 5.929   -23.667 -27.767 1.00 30.70  ? 679  THR   A C   1 
ATOM   2970 O  O   . THR   A 1 416 ? 5.605   -23.149 -26.677 1.00 33.36  ? 679  THR   A O   1 
ATOM   2971 C  CB  . THR   A 1 416 ? 8.275   -23.310 -28.768 1.00 33.74  ? 679  THR   A CB  1 
ATOM   2972 O  OG1 . THR   A 1 416 ? 7.820   -23.195 -30.115 1.00 36.14  ? 679  THR   A OG1 1 
ATOM   2973 C  CG2 . THR   A 1 416 ? 9.703   -23.813 -28.809 1.00 36.07  ? 679  THR   A CG2 1 
ATOM   2974 N  N   . ALA   A 1 417 ? 5.074   -23.799 -28.785 1.00 32.77  ? 680  ALA   A N   1 
ATOM   2975 C  CA  . ALA   A 1 417 ? 3.664   -23.326 -28.712 1.00 30.35  ? 680  ALA   A CA  1 
ATOM   2976 C  C   . ALA   A 1 417 ? 2.918   -24.096 -27.606 1.00 35.90  ? 680  ALA   A C   1 
ATOM   2977 O  O   . ALA   A 1 417 ? 2.290   -23.432 -26.740 1.00 33.91  ? 680  ALA   A O   1 
ATOM   2978 C  CB  . ALA   A 1 417 ? 3.026   -23.441 -30.057 1.00 34.16  ? 680  ALA   A CB  1 
ATOM   2979 N  N   . LEU   A 1 418 ? 3.059   -25.439 -27.564 1.00 33.03  ? 681  LEU   A N   1 
ATOM   2980 C  CA  . LEU   A 1 418 ? 2.312   -26.277 -26.607 1.00 32.48  ? 681  LEU   A CA  1 
ATOM   2981 C  C   . LEU   A 1 418 ? 2.623   -25.812 -25.183 1.00 32.08  ? 681  LEU   A C   1 
ATOM   2982 O  O   . LEU   A 1 418 ? 1.688   -25.614 -24.417 1.00 32.28  ? 681  LEU   A O   1 
ATOM   2983 C  CB  . LEU   A 1 418 ? 2.675   -27.747 -26.841 1.00 29.54  ? 681  LEU   A CB  1 
ATOM   2984 C  CG  . LEU   A 1 418 ? 1.816   -28.725 -26.074 1.00 33.65  ? 681  LEU   A CG  1 
ATOM   2985 C  CD1 . LEU   A 1 418 ? 0.425   -28.804 -26.691 1.00 32.96  ? 681  LEU   A CD1 1 
ATOM   2986 C  CD2 . LEU   A 1 418 ? 2.489   -30.087 -26.017 1.00 33.17  ? 681  LEU   A CD2 1 
ATOM   2987 N  N   . ASN   A 1 419 ? 3.915   -25.592 -24.869 1.00 34.75  ? 682  ASN   A N   1 
ATOM   2988 C  CA  . ASN   A 1 419 ? 4.379   -25.182 -23.520 1.00 33.37  ? 682  ASN   A CA  1 
ATOM   2989 C  C   . ASN   A 1 419 ? 3.918   -23.741 -23.296 1.00 30.91  ? 682  ASN   A C   1 
ATOM   2990 O  O   . ASN   A 1 419 ? 3.374   -23.464 -22.236 1.00 33.20  ? 682  ASN   A O   1 
ATOM   2991 C  CB  . ASN   A 1 419 ? 5.894   -25.411 -23.356 1.00 37.38  ? 682  ASN   A CB  1 
ATOM   2992 C  CG  . ASN   A 1 419 ? 6.259   -26.865 -23.062 1.00 38.00  ? 682  ASN   A CG  1 
ATOM   2993 O  OD1 . ASN   A 1 419 ? 5.469   -27.611 -22.498 1.00 35.68  ? 682  ASN   A OD1 1 
ATOM   2994 N  ND2 . ASN   A 1 419 ? 7.482   -27.280 -23.362 1.00 37.87  ? 682  ASN   A ND2 1 
ATOM   2995 N  N   . ASP   A 1 420 ? 4.022   -22.868 -24.283 1.00 32.72  ? 683  ASP   A N   1 
ATOM   2996 C  CA  . ASP   A 1 420 ? 3.657   -21.440 -24.058 1.00 36.08  ? 683  ASP   A CA  1 
ATOM   2997 C  C   . ASP   A 1 420 ? 2.124   -21.256 -23.951 1.00 40.84  ? 683  ASP   A C   1 
ATOM   2998 O  O   . ASP   A 1 420 ? 1.700   -20.330 -23.263 1.00 36.76  ? 683  ASP   A O   1 
ATOM   2999 C  CB  . ASP   A 1 420 ? 4.223   -20.542 -25.147 1.00 37.07  ? 683  ASP   A CB  1 
ATOM   3000 C  CG  . ASP   A 1 420 ? 4.169   -19.065 -24.770 1.00 41.74  ? 683  ASP   A CG  1 
ATOM   3001 O  OD1 . ASP   A 1 420 ? 4.550   -18.754 -23.624 1.00 42.00  ? 683  ASP   A OD1 1 
ATOM   3002 O  OD2 . ASP   A 1 420 ? 3.709   -18.264 -25.614 1.00 42.73  ? 683  ASP   A OD2 1 
ATOM   3003 N  N   . MET   A 1 421 ? 1.304   -22.099 -24.585 1.00 39.02  ? 684  MET   A N   1 
ATOM   3004 C  CA  . MET   A 1 421 ? -0.174  -22.054 -24.406 1.00 34.47  ? 684  MET   A CA  1 
ATOM   3005 C  C   . MET   A 1 421 ? -0.540  -22.546 -23.003 1.00 34.48  ? 684  MET   A C   1 
ATOM   3006 O  O   . MET   A 1 421 ? -1.712  -22.458 -22.645 1.00 36.53  ? 684  MET   A O   1 
ATOM   3007 C  CB  . MET   A 1 421 ? -0.897  -22.871 -25.483 1.00 35.14  ? 684  MET   A CB  1 
ATOM   3008 C  CG  . MET   A 1 421 ? -0.751  -22.271 -26.867 1.00 35.50  ? 684  MET   A CG  1 
ATOM   3009 S  SD  . MET   A 1 421 ? -1.626  -23.211 -28.207 1.00 38.52  ? 684  MET   A SD  1 
ATOM   3010 C  CE  . MET   A 1 421 ? -0.700  -24.745 -28.231 1.00 40.97  ? 684  MET   A CE  1 
ATOM   3011 N  N   . GLY   A 1 422 ? 0.413   -23.072 -22.227 1.00 37.53  ? 685  GLY   A N   1 
ATOM   3012 C  CA  . GLY   A 1 422 ? 0.189   -23.652 -20.880 1.00 32.30  ? 685  GLY   A CA  1 
ATOM   3013 C  C   . GLY   A 1 422 ? -0.189  -25.134 -20.870 1.00 30.74  ? 685  GLY   A C   1 
ATOM   3014 O  O   . GLY   A 1 422 ? -0.410  -25.691 -19.773 1.00 35.06  ? 685  GLY   A O   1 
ATOM   3015 N  N   . LYS   A 1 423 ? -0.257  -25.796 -22.019 1.00 29.98  ? 686  LYS   A N   1 
ATOM   3016 C  CA  . LYS   A 1 423 ? -0.674  -27.235 -22.085 1.00 34.52  ? 686  LYS   A CA  1 
ATOM   3017 C  C   . LYS   A 1 423 ? 0.543   -28.165 -21.900 1.00 35.17  ? 686  LYS   A C   1 
ATOM   3018 O  O   . LYS   A 1 423 ? 0.860   -28.968 -22.804 1.00 31.82  ? 686  LYS   A O   1 
ATOM   3019 C  CB  . LYS   A 1 423 ? -1.454  -27.459 -23.374 1.00 30.85  ? 686  LYS   A CB  1 
ATOM   3020 C  CG  . LYS   A 1 423 ? -2.576  -26.455 -23.587 1.00 30.07  ? 686  LYS   A CG  1 
ATOM   3021 C  CD  . LYS   A 1 423 ? -3.569  -26.422 -22.442 1.00 32.76  ? 686  LYS   A CD  1 
ATOM   3022 C  CE  . LYS   A 1 423 ? -4.751  -25.490 -22.665 1.00 36.34  ? 686  LYS   A CE  1 
ATOM   3023 N  NZ  . LYS   A 1 423 ? -4.343  -24.072 -22.429 1.00 37.84  ? 686  LYS   A NZ  1 
ATOM   3024 N  N   . VAL   A 1 424 ? 1.151   -28.087 -20.714 1.00 36.82  ? 687  VAL   A N   1 
ATOM   3025 C  CA  . VAL   A 1 424 ? 2.350   -28.868 -20.285 1.00 35.62  ? 687  VAL   A CA  1 
ATOM   3026 C  C   . VAL   A 1 424 ? 1.992   -30.347 -20.193 1.00 29.96  ? 687  VAL   A C   1 
ATOM   3027 O  O   . VAL   A 1 424 ? 0.976   -30.705 -19.526 1.00 35.38  ? 687  VAL   A O   1 
ATOM   3028 C  CB  . VAL   A 1 424 ? 2.928   -28.318 -18.955 1.00 43.40  ? 687  VAL   A CB  1 
ATOM   3029 C  CG1 . VAL   A 1 424 ? 3.995   -29.221 -18.360 1.00 49.61  ? 687  VAL   A CG1 1 
ATOM   3030 C  CG2 . VAL   A 1 424 ? 3.504   -26.920 -19.155 1.00 42.16  ? 687  VAL   A CG2 1 
ATOM   3031 N  N   . ARG   A 1 425 ? 2.813   -31.186 -20.843 1.00 29.12  ? 688  ARG   A N   1 
ATOM   3032 C  CA  . ARG   A 1 425 ? 2.640   -32.650 -20.895 1.00 33.95  ? 688  ARG   A CA  1 
ATOM   3033 C  C   . ARG   A 1 425 ? 2.873   -33.223 -19.506 1.00 34.87  ? 688  ARG   A C   1 
ATOM   3034 O  O   . ARG   A 1 425 ? 3.781   -32.708 -18.832 1.00 38.97  ? 688  ARG   A O   1 
ATOM   3035 C  CB  . ARG   A 1 425 ? 3.564   -33.295 -21.927 1.00 31.23  ? 688  ARG   A CB  1 
ATOM   3036 C  CG  . ARG   A 1 425 ? 3.187   -32.899 -23.341 1.00 31.40  ? 688  ARG   A CG  1 
ATOM   3037 C  CD  . ARG   A 1 425 ? 4.295   -33.178 -24.317 1.00 33.25  ? 688  ARG   A CD  1 
ATOM   3038 N  NE  . ARG   A 1 425 ? 5.533   -32.548 -23.882 1.00 33.50  ? 688  ARG   A NE  1 
ATOM   3039 C  CZ  . ARG   A 1 425 ? 6.773   -33.000 -24.146 1.00 34.52  ? 688  ARG   A CZ  1 
ATOM   3040 N  NH1 . ARG   A 1 425 ? 6.985   -34.069 -24.910 1.00 30.93  ? 688  ARG   A NH1 1 
ATOM   3041 N  NH2 . ARG   A 1 425 ? 7.810   -32.338 -23.638 1.00 35.40  ? 688  ARG   A NH2 1 
ATOM   3042 N  N   . LYS   A 1 426 ? 2.076   -34.234 -19.146 1.00 33.73  ? 689  LYS   A N   1 
ATOM   3043 C  CA  . LYS   A 1 426 ? 2.189   -35.036 -17.904 1.00 38.65  ? 689  LYS   A CA  1 
ATOM   3044 C  C   . LYS   A 1 426 ? 3.380   -36.020 -18.027 1.00 40.87  ? 689  LYS   A C   1 
ATOM   3045 O  O   . LYS   A 1 426 ? 3.582   -36.564 -19.117 1.00 41.08  ? 689  LYS   A O   1 
ATOM   3046 C  CB  . LYS   A 1 426 ? 0.878   -35.802 -17.699 1.00 41.14  ? 689  LYS   A CB  1 
ATOM   3047 C  CG  . LYS   A 1 426 ? 0.592   -36.254 -16.271 1.00 51.37  ? 689  LYS   A CG  1 
ATOM   3048 C  CD  . LYS   A 1 426 ? -0.671  -37.083 -16.123 1.00 57.84  ? 689  LYS   A CD  1 
ATOM   3049 C  CE  . LYS   A 1 426 ? -0.784  -38.150 -17.192 1.00 68.91  ? 689  LYS   A CE  1 
ATOM   3050 N  NZ  . LYS   A 1 426 ? -1.787  -39.192 -16.879 1.00 74.84  ? 689  LYS   A NZ  1 
ATOM   3051 N  N   . ASP   A 1 427 ? 4.136   -36.264 -16.955 1.00 48.83  ? 690  ASP   A N   1 
ATOM   3052 C  CA  . ASP   A 1 427 ? 5.031   -37.458 -16.819 1.00 48.67  ? 690  ASP   A CA  1 
ATOM   3053 C  C   . ASP   A 1 427 ? 6.131   -37.466 -17.894 1.00 50.54  ? 690  ASP   A C   1 
ATOM   3054 O  O   . ASP   A 1 427 ? 6.466   -38.572 -18.411 1.00 51.24  ? 690  ASP   A O   1 
ATOM   3055 C  CB  . ASP   A 1 427 ? 4.234   -38.764 -16.911 1.00 55.37  ? 690  ASP   A CB  1 
ATOM   3056 C  CG  . ASP   A 1 427 ? 3.284   -38.957 -15.740 1.00 67.35  ? 690  ASP   A CG  1 
ATOM   3057 O  OD1 . ASP   A 1 427 ? 3.455   -38.207 -14.726 1.00 63.60  ? 690  ASP   A OD1 1 
ATOM   3058 O  OD2 . ASP   A 1 427 ? 2.369   -39.837 -15.857 1.00 67.22  ? 690  ASP   A OD2 1 
ATOM   3059 N  N   . ILE   A 1 428 ? 6.669   -36.285 -18.206 1.00 41.25  ? 691  ILE   A N   1 
ATOM   3060 C  CA  . ILE   A 1 428 ? 7.810   -36.095 -19.141 1.00 43.18  ? 691  ILE   A CA  1 
ATOM   3061 C  C   . ILE   A 1 428 ? 8.364   -34.717 -18.822 1.00 43.01  ? 691  ILE   A C   1 
ATOM   3062 O  O   . ILE   A 1 428 ? 7.586   -33.897 -18.334 1.00 45.79  ? 691  ILE   A O   1 
ATOM   3063 C  CB  . ILE   A 1 428 ? 7.380   -36.270 -20.619 1.00 41.65  ? 691  ILE   A CB  1 
ATOM   3064 C  CG1 . ILE   A 1 428 ? 8.599   -36.348 -21.526 1.00 42.12  ? 691  ILE   A CG1 1 
ATOM   3065 C  CG2 . ILE   A 1 428 ? 6.394   -35.196 -21.098 1.00 38.97  ? 691  ILE   A CG2 1 
ATOM   3066 C  CD1 . ILE   A 1 428 ? 8.319   -36.944 -22.852 1.00 41.69  ? 691  ILE   A CD1 1 
ATOM   3067 N  N   . GLN   A 1 429 ? 9.652   -34.481 -19.052 1.00 44.06  ? 692  GLN   A N   1 
ATOM   3068 C  CA  . GLN   A 1 429 ? 10.300  -33.180 -18.754 1.00 45.92  ? 692  GLN   A CA  1 
ATOM   3069 C  C   . GLN   A 1 429 ? 9.970   -32.220 -19.894 1.00 43.42  ? 692  GLN   A C   1 
ATOM   3070 O  O   . GLN   A 1 429 ? 9.805   -32.662 -21.044 1.00 37.81  ? 692  GLN   A O   1 
ATOM   3071 C  CB  . GLN   A 1 429 ? 11.813  -33.351 -18.548 1.00 58.54  ? 692  GLN   A CB  1 
ATOM   3072 C  CG  . GLN   A 1 429 ? 12.161  -34.348 -17.438 1.00 70.58  ? 692  GLN   A CG  1 
ATOM   3073 C  CD  . GLN   A 1 429 ? 13.629  -34.709 -17.355 1.00 87.12  ? 692  GLN   A CD  1 
ATOM   3074 O  OE1 . GLN   A 1 429 ? 14.121  -35.561 -18.096 1.00 93.47  ? 692  GLN   A OE1 1 
ATOM   3075 N  NE2 . GLN   A 1 429 ? 14.342  -34.085 -16.425 1.00 93.23  ? 692  GLN   A NE2 1 
ATOM   3076 N  N   . GLN   A 1 430 ? 9.928   -30.945 -19.579 1.00 46.86  ? 693  GLN   A N   1 
ATOM   3077 C  CA  . GLN   A 1 430 ? 9.311   -29.895 -20.410 1.00 48.49  ? 693  GLN   A CA  1 
ATOM   3078 C  C   . GLN   A 1 430 ? 9.821   -29.948 -21.849 1.00 50.88  ? 693  GLN   A C   1 
ATOM   3079 O  O   . GLN   A 1 430 ? 8.996   -29.652 -22.778 1.00 43.08  ? 693  GLN   A O   1 
ATOM   3080 C  CB  . GLN   A 1 430 ? 9.589   -28.530 -19.784 1.00 58.59  ? 693  GLN   A CB  1 
ATOM   3081 C  CG  . GLN   A 1 430 ? 8.781   -27.417 -20.429 1.00 67.30  ? 693  GLN   A CG  1 
ATOM   3082 C  CD  . GLN   A 1 430 ? 8.537   -26.264 -19.489 1.00 71.62  ? 693  GLN   A CD  1 
ATOM   3083 O  OE1 . GLN   A 1 430 ? 7.389   -25.889 -19.237 1.00 63.96  ? 693  GLN   A OE1 1 
ATOM   3084 N  NE2 . GLN   A 1 430 ? 9.620   -25.724 -18.944 1.00 64.38  ? 693  GLN   A NE2 1 
ATOM   3085 N  N   . TRP   A 1 431 ? 11.116  -30.232 -22.058 1.00 36.97  ? 694  TRP   A N   1 
ATOM   3086 C  CA  . TRP   A 1 431 ? 11.739  -30.062 -23.386 1.00 40.70  ? 694  TRP   A CA  1 
ATOM   3087 C  C   . TRP   A 1 431 ? 12.169  -31.417 -23.956 1.00 37.04  ? 694  TRP   A C   1 
ATOM   3088 O  O   . TRP   A 1 431 ? 12.706  -31.417 -25.035 1.00 39.50  ? 694  TRP   A O   1 
ATOM   3089 C  CB  . TRP   A 1 431 ? 12.856  -29.020 -23.296 1.00 46.35  ? 694  TRP   A CB  1 
ATOM   3090 C  CG  . TRP   A 1 431 ? 12.335  -27.676 -22.862 1.00 55.54  ? 694  TRP   A CG  1 
ATOM   3091 C  CD1 . TRP   A 1 431 ? 12.560  -27.042 -21.668 1.00 53.81  ? 694  TRP   A CD1 1 
ATOM   3092 C  CD2 . TRP   A 1 431 ? 11.443  -26.815 -23.603 1.00 51.17  ? 694  TRP   A CD2 1 
ATOM   3093 N  NE1 . TRP   A 1 431 ? 11.894  -25.842 -21.630 1.00 53.49  ? 694  TRP   A NE1 1 
ATOM   3094 C  CE2 . TRP   A 1 431 ? 11.212  -25.668 -22.806 1.00 54.61  ? 694  TRP   A CE2 1 
ATOM   3095 C  CE3 . TRP   A 1 431 ? 10.860  -26.876 -24.877 1.00 49.33  ? 694  TRP   A CE3 1 
ATOM   3096 C  CZ2 . TRP   A 1 431 ? 10.383  -24.623 -23.222 1.00 51.65  ? 694  TRP   A CZ2 1 
ATOM   3097 C  CZ3 . TRP   A 1 431 ? 10.063  -25.829 -25.299 1.00 52.21  ? 694  TRP   A CZ3 1 
ATOM   3098 C  CH2 . TRP   A 1 431 ? 9.828   -24.721 -24.480 1.00 52.18  ? 694  TRP   A CH2 1 
ATOM   3099 N  N   . GLU   A 1 432 ? 11.814  -32.514 -23.301 1.00 37.38  ? 695  GLU   A N   1 
ATOM   3100 C  CA  . GLU   A 1 432 ? 12.081  -33.895 -23.790 1.00 41.78  ? 695  GLU   A CA  1 
ATOM   3101 C  C   . GLU   A 1 432 ? 11.051  -34.180 -24.891 1.00 40.51  ? 695  GLU   A C   1 
ATOM   3102 O  O   . GLU   A 1 432 ? 9.844   -33.922 -24.724 1.00 36.45  ? 695  GLU   A O   1 
ATOM   3103 C  CB  . GLU   A 1 432 ? 12.062  -34.836 -22.584 1.00 45.56  ? 695  GLU   A CB  1 
ATOM   3104 C  CG  . GLU   A 1 432 ? 12.436  -36.273 -22.878 1.00 63.14  ? 695  GLU   A CG  1 
ATOM   3105 C  CD  . GLU   A 1 432 ? 13.894  -36.492 -23.276 1.00 81.14  ? 695  GLU   A CD  1 
ATOM   3106 O  OE1 . GLU   A 1 432 ? 14.185  -37.582 -23.826 1.00 86.20  ? 695  GLU   A OE1 1 
ATOM   3107 O  OE2 . GLU   A 1 432 ? 14.744  -35.573 -23.057 1.00 83.07  ? 695  GLU   A OE2 1 
ATOM   3108 N  N   . PRO   A 1 433 ? 11.511  -34.653 -26.056 1.00 38.56  ? 696  PRO   A N   1 
ATOM   3109 C  CA  . PRO   A 1 433 ? 10.625  -34.979 -27.172 1.00 34.75  ? 696  PRO   A CA  1 
ATOM   3110 C  C   . PRO   A 1 433 ? 9.585   -36.031 -26.782 1.00 32.57  ? 696  PRO   A C   1 
ATOM   3111 O  O   . PRO   A 1 433 ? 9.850   -36.887 -26.003 1.00 29.45  ? 696  PRO   A O   1 
ATOM   3112 C  CB  . PRO   A 1 433 ? 11.548  -35.534 -28.269 1.00 41.72  ? 696  PRO   A CB  1 
ATOM   3113 C  CG  . PRO   A 1 433 ? 12.965  -35.054 -27.845 1.00 45.39  ? 696  PRO   A CG  1 
ATOM   3114 C  CD  . PRO   A 1 433 ? 12.928  -35.008 -26.335 1.00 39.15  ? 696  PRO   A CD  1 
ATOM   3115 N  N   . SER   A 1 434 ? 8.353   -35.898 -27.273 1.00 31.87  ? 697  SER   A N   1 
ATOM   3116 C  CA  . SER   A 1 434 ? 7.310   -36.924 -27.020 1.00 31.14  ? 697  SER   A CA  1 
ATOM   3117 C  C   . SER   A 1 434 ? 7.738   -38.284 -27.554 1.00 31.92  ? 697  SER   A C   1 
ATOM   3118 O  O   . SER   A 1 434 ? 8.355   -38.350 -28.614 1.00 36.09  ? 697  SER   A O   1 
ATOM   3119 C  CB  . SER   A 1 434 ? 6.036   -36.501 -27.704 1.00 31.28  ? 697  SER   A CB  1 
ATOM   3120 O  OG  . SER   A 1 434 ? 5.501   -35.356 -27.086 1.00 26.56  ? 697  SER   A OG  1 
ATOM   3121 N  N   . ARG   A 1 435 ? 7.405   -39.363 -26.843 0.50 34.41  ? 698  ARG   A N   1 
ATOM   3122 C  CA  . ARG   A 1 435 ? 7.521   -40.742 -27.392 0.50 37.44  ? 698  ARG   A CA  1 
ATOM   3123 C  C   . ARG   A 1 435 ? 6.185   -41.107 -28.050 0.50 35.95  ? 698  ARG   A C   1 
ATOM   3124 O  O   . ARG   A 1 435 ? 5.134   -40.948 -27.411 0.50 38.26  ? 698  ARG   A O   1 
ATOM   3125 C  CB  . ARG   A 1 435 ? 7.941   -41.753 -26.320 0.50 41.63  ? 698  ARG   A CB  1 
ATOM   3126 C  CG  . ARG   A 1 435 ? 7.051   -41.798 -25.087 0.50 43.28  ? 698  ARG   A CG  1 
ATOM   3127 C  CD  . ARG   A 1 435 ? 7.721   -42.515 -23.923 0.50 47.90  ? 698  ARG   A CD  1 
ATOM   3128 N  NE  . ARG   A 1 435 ? 7.001   -42.313 -22.670 0.50 52.42  ? 698  ARG   A NE  1 
ATOM   3129 C  CZ  . ARG   A 1 435 ? 7.205   -41.290 -21.844 0.50 54.19  ? 698  ARG   A CZ  1 
ATOM   3130 N  NH1 . ARG   A 1 435 ? 8.120   -40.382 -22.131 0.50 55.90  ? 698  ARG   A NH1 1 
ATOM   3131 N  NH2 . ARG   A 1 435 ? 6.503   -41.179 -20.730 0.50 56.20  ? 698  ARG   A NH2 1 
ATOM   3132 N  N   . GLY   A 1 436 ? 6.243   -41.563 -29.295 1.00 34.59  ? 699  GLY   A N   1 
ATOM   3133 C  CA  . GLY   A 1 436 ? 5.073   -41.957 -30.069 1.00 36.06  ? 699  GLY   A CA  1 
ATOM   3134 C  C   . GLY   A 1 436 ? 4.864   -43.457 -30.008 1.00 33.96  ? 699  GLY   A C   1 
ATOM   3135 O  O   . GLY   A 1 436 ? 5.725   -44.201 -29.507 1.00 34.62  ? 699  GLY   A O   1 
ATOM   3136 N  N   . TRP   A 1 437 ? 3.718   -43.896 -30.520 0.50 32.01  ? 700  TRP   A N   1 
ATOM   3137 C  CA  . TRP   A 1 437 ? 3.328   -45.321 -30.620 0.50 31.17  ? 700  TRP   A CA  1 
ATOM   3138 C  C   . TRP   A 1 437 ? 3.430   -45.749 -32.083 0.50 32.05  ? 700  TRP   A C   1 
ATOM   3139 O  O   . TRP   A 1 437 ? 2.951   -44.996 -32.951 0.50 31.79  ? 700  TRP   A O   1 
ATOM   3140 C  CB  . TRP   A 1 437 ? 1.920   -45.513 -30.054 0.50 30.15  ? 700  TRP   A CB  1 
ATOM   3141 C  CG  . TRP   A 1 437 ? 1.777   -45.055 -28.637 0.50 29.20  ? 700  TRP   A CG  1 
ATOM   3142 C  CD1 . TRP   A 1 437 ? 1.488   -43.796 -28.199 0.50 31.48  ? 700  TRP   A CD1 1 
ATOM   3143 C  CD2 . TRP   A 1 437 ? 1.922   -45.863 -27.458 0.50 29.39  ? 700  TRP   A CD2 1 
ATOM   3144 N  NE1 . TRP   A 1 437 ? 1.428   -43.769 -26.832 0.50 31.65  ? 700  TRP   A NE1 1 
ATOM   3145 C  CE2 . TRP   A 1 437 ? 1.686   -45.026 -26.350 0.50 29.99  ? 700  TRP   A CE2 1 
ATOM   3146 C  CE3 . TRP   A 1 437 ? 2.215   -47.209 -27.240 0.50 30.31  ? 700  TRP   A CE3 1 
ATOM   3147 C  CZ2 . TRP   A 1 437 ? 1.735   -45.493 -25.040 0.50 31.22  ? 700  TRP   A CZ2 1 
ATOM   3148 C  CZ3 . TRP   A 1 437 ? 2.262   -47.672 -25.945 0.50 31.50  ? 700  TRP   A CZ3 1 
ATOM   3149 C  CH2 . TRP   A 1 437 ? 2.018   -46.826 -24.864 0.50 31.55  ? 700  TRP   A CH2 1 
ATOM   3150 N  N   . ASN   A 1 438 ? 4.052   -46.902 -32.337 1.00 30.50  ? 701  ASN   A N   1 
ATOM   3151 C  CA  . ASN   A 1 438 ? 4.194   -47.437 -33.697 1.00 32.51  ? 701  ASN   A CA  1 
ATOM   3152 C  C   . ASN   A 1 438 ? 2.979   -48.266 -34.066 1.00 33.89  ? 701  ASN   A C   1 
ATOM   3153 O  O   . ASN   A 1 438 ? 2.872   -48.595 -35.210 1.00 37.58  ? 701  ASN   A O   1 
ATOM   3154 C  CB  . ASN   A 1 438 ? 5.491   -48.264 -33.791 1.00 39.22  ? 701  ASN   A CB  1 
ATOM   3155 C  CG  . ASN   A 1 438 ? 6.685   -47.382 -33.474 1.00 50.13  ? 701  ASN   A CG  1 
ATOM   3156 O  OD1 . ASN   A 1 438 ? 7.475   -47.686 -32.578 1.00 61.85  ? 701  ASN   A OD1 1 
ATOM   3157 N  ND2 . ASN   A 1 438 ? 6.753   -46.233 -34.129 1.00 39.69  ? 701  ASN   A ND2 1 
ATOM   3158 N  N   . ASP   A 1 439 ? 2.098   -48.621 -33.143 1.00 32.22  ? 702  ASP   A N   1 
ATOM   3159 C  CA  . ASP   A 1 439 ? 1.016   -49.593 -33.473 1.00 34.56  ? 702  ASP   A CA  1 
ATOM   3160 C  C   . ASP   A 1 439 ? -0.263  -49.082 -32.819 1.00 32.70  ? 702  ASP   A C   1 
ATOM   3161 O  O   . ASP   A 1 439 ? -0.247  -48.848 -31.586 1.00 29.55  ? 702  ASP   A O   1 
ATOM   3162 C  CB  . ASP   A 1 439 ? 1.545   -50.974 -33.077 1.00 41.40  ? 702  ASP   A CB  1 
ATOM   3163 C  CG  . ASP   A 1 439 ? 0.551   -52.112 -32.979 1.00 44.30  ? 702  ASP   A CG  1 
ATOM   3164 O  OD1 . ASP   A 1 439 ? -0.635  -51.942 -33.456 1.00 41.66  ? 702  ASP   A OD1 1 
ATOM   3165 O  OD2 . ASP   A 1 439 ? 0.969   -53.158 -32.347 1.00 48.67  ? 702  ASP   A OD2 1 
ATOM   3166 N  N   . TRP   A 1 440 ? -1.292  -48.871 -33.629 1.00 30.06  ? 703  TRP   A N   1 
ATOM   3167 C  CA  . TRP   A 1 440 ? -2.577  -48.288 -33.185 1.00 28.76  ? 703  TRP   A CA  1 
ATOM   3168 C  C   . TRP   A 1 440 ? -3.207  -49.119 -32.065 1.00 27.40  ? 703  TRP   A C   1 
ATOM   3169 O  O   . TRP   A 1 440 ? -3.964  -48.521 -31.241 1.00 25.57  ? 703  TRP   A O   1 
ATOM   3170 C  CB  . TRP   A 1 440 ? -3.519  -48.076 -34.363 1.00 28.90  ? 703  TRP   A CB  1 
ATOM   3171 C  CG  . TRP   A 1 440 ? -4.045  -49.320 -35.000 1.00 29.45  ? 703  TRP   A CG  1 
ATOM   3172 C  CD1 . TRP   A 1 440 ? -3.498  -49.987 -36.056 1.00 32.57  ? 703  TRP   A CD1 1 
ATOM   3173 C  CD2 . TRP   A 1 440 ? -5.195  -50.078 -34.615 1.00 29.14  ? 703  TRP   A CD2 1 
ATOM   3174 N  NE1 . TRP   A 1 440 ? -4.262  -51.061 -36.393 1.00 30.93  ? 703  TRP   A NE1 1 
ATOM   3175 C  CE2 . TRP   A 1 440 ? -5.296  -51.167 -35.514 1.00 29.83  ? 703  TRP   A CE2 1 
ATOM   3176 C  CE3 . TRP   A 1 440 ? -6.174  -49.916 -33.638 1.00 27.98  ? 703  TRP   A CE3 1 
ATOM   3177 C  CZ2 . TRP   A 1 440 ? -6.320  -52.119 -35.441 1.00 29.23  ? 703  TRP   A CZ2 1 
ATOM   3178 C  CZ3 . TRP   A 1 440 ? -7.196  -50.840 -33.576 1.00 28.37  ? 703  TRP   A CZ3 1 
ATOM   3179 C  CH2 . TRP   A 1 440 ? -7.261  -51.928 -34.453 1.00 30.85  ? 703  TRP   A CH2 1 
ATOM   3180 N  N   . THR   A 1 441 ? -2.878  -50.408 -31.990 1.00 26.21  ? 704  THR   A N   1 
ATOM   3181 C  CA  . THR   A 1 441 ? -3.425  -51.349 -30.970 1.00 27.88  ? 704  THR   A CA  1 
ATOM   3182 C  C   . THR   A 1 441 ? -2.792  -51.135 -29.599 1.00 27.52  ? 704  THR   A C   1 
ATOM   3183 O  O   . THR   A 1 441 ? -3.279  -51.722 -28.624 1.00 29.83  ? 704  THR   A O   1 
ATOM   3184 C  CB  . THR   A 1 441 ? -3.335  -52.830 -31.383 1.00 27.91  ? 704  THR   A CB  1 
ATOM   3185 O  OG1 . THR   A 1 441 ? -1.979  -53.280 -31.516 1.00 27.59  ? 704  THR   A OG1 1 
ATOM   3186 C  CG2 . THR   A 1 441 ? -4.045  -53.096 -32.695 1.00 26.81  ? 704  THR   A CG2 1 
ATOM   3187 N  N   . GLN   A 1 442 ? -1.731  -50.324 -29.522 0.50 27.76  ? 705  GLN   A N   1 
ATOM   3188 C  CA  . GLN   A 1 442 ? -1.019  -50.003 -28.257 0.50 28.04  ? 705  GLN   A CA  1 
ATOM   3189 C  C   . GLN   A 1 442 ? -1.374  -48.596 -27.764 0.50 25.81  ? 705  GLN   A C   1 
ATOM   3190 O  O   . GLN   A 1 442 ? -1.003  -48.282 -26.630 0.50 25.95  ? 705  GLN   A O   1 
ATOM   3191 C  CB  . GLN   A 1 442 ? 0.489   -50.139 -28.460 0.50 30.03  ? 705  GLN   A CB  1 
ATOM   3192 C  CG  . GLN   A 1 442 ? 0.869   -51.431 -29.166 0.50 32.46  ? 705  GLN   A CG  1 
ATOM   3193 C  CD  . GLN   A 1 442 ? 0.380   -52.633 -28.402 0.50 32.75  ? 705  GLN   A CD  1 
ATOM   3194 O  OE1 . GLN   A 1 442 ? 0.742   -52.831 -27.248 0.50 31.64  ? 705  GLN   A OE1 1 
ATOM   3195 N  NE2 . GLN   A 1 442 ? -0.448  -53.451 -29.042 0.50 37.04  ? 705  GLN   A NE2 1 
ATOM   3196 N  N   . VAL   A 1 443 ? -2.029  -47.778 -28.587 1.00 24.90  ? 706  VAL   A N   1 
ATOM   3197 C  CA  . VAL   A 1 443 ? -2.306  -46.337 -28.252 1.00 27.43  ? 706  VAL   A CA  1 
ATOM   3198 C  C   . VAL   A 1 443 ? -3.350  -46.255 -27.153 1.00 23.72  ? 706  VAL   A C   1 
ATOM   3199 O  O   . VAL   A 1 443 ? -4.387  -46.897 -27.259 1.00 24.66  ? 706  VAL   A O   1 
ATOM   3200 C  CB  . VAL   A 1 443 ? -2.746  -45.567 -29.511 1.00 31.47  ? 706  VAL   A CB  1 
ATOM   3201 C  CG1 . VAL   A 1 443 ? -3.298  -44.189 -29.225 1.00 35.98  ? 706  VAL   A CG1 1 
ATOM   3202 C  CG2 . VAL   A 1 443 ? -1.566  -45.457 -30.455 1.00 37.95  ? 706  VAL   A CG2 1 
ATOM   3203 N  N   . PRO   A 1 444 ? -3.135  -45.480 -26.068 1.00 23.35  ? 707  PRO   A N   1 
ATOM   3204 C  CA  . PRO   A 1 444 ? -4.206  -45.241 -25.108 1.00 23.10  ? 707  PRO   A CA  1 
ATOM   3205 C  C   . PRO   A 1 444 ? -5.194  -44.175 -25.597 1.00 25.04  ? 707  PRO   A C   1 
ATOM   3206 O  O   . PRO   A 1 444 ? -4.745  -43.190 -26.180 1.00 22.96  ? 707  PRO   A O   1 
ATOM   3207 C  CB  . PRO   A 1 444 ? -3.462  -44.730 -23.876 1.00 27.27  ? 707  PRO   A CB  1 
ATOM   3208 C  CG  . PRO   A 1 444 ? -2.175  -44.079 -24.416 1.00 26.04  ? 707  PRO   A CG  1 
ATOM   3209 C  CD  . PRO   A 1 444 ? -1.886  -44.763 -25.731 1.00 24.07  ? 707  PRO   A CD  1 
ATOM   3210 N  N   . PHE   A 1 445 ? -6.491  -44.360 -25.380 1.00 22.40  ? 708  PHE   A N   1 
ATOM   3211 C  CA  . PHE   A 1 445 ? -7.499  -43.300 -25.698 1.00 21.89  ? 708  PHE   A CA  1 
ATOM   3212 C  C   . PHE   A 1 445 ? -8.760  -43.531 -24.877 1.00 22.75  ? 708  PHE   A C   1 
ATOM   3213 O  O   . PHE   A 1 445 ? -9.217  -44.689 -24.880 1.00 20.43  ? 708  PHE   A O   1 
ATOM   3214 C  CB  . PHE   A 1 445 ? -7.820  -43.321 -27.193 1.00 20.75  ? 708  PHE   A CB  1 
ATOM   3215 C  CG  . PHE   A 1 445 ? -8.714  -42.187 -27.666 1.00 23.90  ? 708  PHE   A CG  1 
ATOM   3216 C  CD1 . PHE   A 1 445 ? -8.391  -40.874 -27.382 1.00 23.35  ? 708  PHE   A CD1 1 
ATOM   3217 C  CD2 . PHE   A 1 445 ? -9.830  -42.442 -28.451 1.00 26.58  ? 708  PHE   A CD2 1 
ATOM   3218 C  CE1 . PHE   A 1 445 ? -9.153  -39.820 -27.870 1.00 23.92  ? 708  PHE   A CE1 1 
ATOM   3219 C  CE2 . PHE   A 1 445 ? -10.594 -41.391 -28.942 1.00 26.34  ? 708  PHE   A CE2 1 
ATOM   3220 C  CZ  . PHE   A 1 445 ? -10.267 -40.085 -28.619 1.00 25.61  ? 708  PHE   A CZ  1 
ATOM   3221 N  N   . CYS   A 1 446 ? -9.265  -42.517 -24.156 1.00 22.56  ? 709  CYS   A N   1 
ATOM   3222 C  CA  . CYS   A 1 446 ? -10.547 -42.647 -23.384 1.00 24.51  ? 709  CYS   A CA  1 
ATOM   3223 C  C   . CYS   A 1 446 ? -10.462 -43.846 -22.407 1.00 23.84  ? 709  CYS   A C   1 
ATOM   3224 O  O   . CYS   A 1 446 ? -11.441 -44.615 -22.341 1.00 25.02  ? 709  CYS   A O   1 
ATOM   3225 C  CB  . CYS   A 1 446 ? -11.708 -42.775 -24.356 1.00 28.02  ? 709  CYS   A CB  1 
ATOM   3226 S  SG  . CYS   A 1 446 ? -11.926 -41.219 -25.274 1.00 29.48  ? 709  CYS   A SG  1 
ATOM   3227 N  N   . SER   A 1 447 ? -9.298  -44.006 -21.763 1.00 23.21  ? 710  SER   A N   1 
ATOM   3228 C  CA  . SER   A 1 447 ? -8.968  -45.009 -20.707 1.00 28.25  ? 710  SER   A CA  1 
ATOM   3229 C  C   . SER   A 1 447 ? -8.923  -46.446 -21.269 1.00 25.55  ? 710  SER   A C   1 
ATOM   3230 O  O   . SER   A 1 447 ? -8.892  -47.392 -20.467 1.00 26.58  ? 710  SER   A O   1 
ATOM   3231 C  CB  . SER   A 1 447 ? -9.984  -44.958 -19.547 1.00 31.70  ? 710  SER   A CB  1 
ATOM   3232 O  OG  . SER   A 1 447 ? -10.170 -43.632 -19.057 1.00 32.90  ? 710  SER   A OG  1 
ATOM   3233 N  N   . HIS   A 1 448 ? -8.872  -46.630 -22.581 1.00 22.31  ? 711  HIS   A N   1 
ATOM   3234 C  CA  . HIS   A 1 448 ? -8.885  -47.954 -23.233 1.00 21.18  ? 711  HIS   A CA  1 
ATOM   3235 C  C   . HIS   A 1 448 ? -7.679  -48.126 -24.161 1.00 20.17  ? 711  HIS   A C   1 
ATOM   3236 O  O   . HIS   A 1 448 ? -6.969  -47.117 -24.482 1.00 19.97  ? 711  HIS   A O   1 
ATOM   3237 C  CB  . HIS   A 1 448 ? -10.187 -48.205 -24.013 1.00 21.92  ? 711  HIS   A CB  1 
ATOM   3238 C  CG  . HIS   A 1 448 ? -11.376 -48.386 -23.147 1.00 22.41  ? 711  HIS   A CG  1 
ATOM   3239 N  ND1 . HIS   A 1 448 ? -11.985 -47.326 -22.479 1.00 22.70  ? 711  HIS   A ND1 1 
ATOM   3240 C  CD2 . HIS   A 1 448 ? -12.094 -49.501 -22.875 1.00 21.67  ? 711  HIS   A CD2 1 
ATOM   3241 C  CE1 . HIS   A 1 448 ? -13.006 -47.811 -21.748 1.00 24.05  ? 711  HIS   A CE1 1 
ATOM   3242 N  NE2 . HIS   A 1 448 ? -13.100 -49.158 -22.005 1.00 21.11  ? 711  HIS   A NE2 1 
ATOM   3243 N  N   . HIS   A 1 449 ? -7.442  -49.388 -24.557 1.00 18.96  ? 712  HIS   A N   1 
ATOM   3244 C  CA  . HIS   A 1 449 ? -6.723  -49.730 -25.792 1.00 19.37  ? 712  HIS   A CA  1 
ATOM   3245 C  C   . HIS   A 1 449 ? -7.658  -50.598 -26.609 1.00 19.39  ? 712  HIS   A C   1 
ATOM   3246 O  O   . HIS   A 1 449 ? -8.714  -50.936 -26.107 1.00 21.89  ? 712  HIS   A O   1 
ATOM   3247 C  CB  . HIS   A 1 449 ? -5.405  -50.435 -25.520 1.00 19.19  ? 712  HIS   A CB  1 
ATOM   3248 C  CG  . HIS   A 1 449 ? -5.563  -51.648 -24.666 1.00 20.01  ? 712  HIS   A CG  1 
ATOM   3249 N  ND1 . HIS   A 1 449 ? -5.746  -51.547 -23.299 1.00 21.91  ? 712  HIS   A ND1 1 
ATOM   3250 C  CD2 . HIS   A 1 449 ? -5.662  -52.946 -24.975 1.00 21.23  ? 712  HIS   A CD2 1 
ATOM   3251 C  CE1 . HIS   A 1 449 ? -5.982  -52.750 -22.808 1.00 21.26  ? 712  HIS   A CE1 1 
ATOM   3252 N  NE2 . HIS   A 1 449 ? -5.895  -53.635 -23.807 1.00 20.64  ? 712  HIS   A NE2 1 
ATOM   3253 N  N   . PHE   A 1 450 ? -7.253  -50.968 -27.816 1.00 20.38  ? 713  PHE   A N   1 
ATOM   3254 C  CA  . PHE   A 1 450 ? -8.150  -51.596 -28.802 1.00 20.51  ? 713  PHE   A CA  1 
ATOM   3255 C  C   . PHE   A 1 450 ? -7.450  -52.789 -29.442 1.00 23.39  ? 713  PHE   A C   1 
ATOM   3256 O  O   . PHE   A 1 450 ? -6.270  -52.675 -29.801 1.00 25.28  ? 713  PHE   A O   1 
ATOM   3257 C  CB  . PHE   A 1 450 ? -8.642  -50.532 -29.790 1.00 23.69  ? 713  PHE   A CB  1 
ATOM   3258 C  CG  . PHE   A 1 450 ? -9.366  -49.409 -29.084 1.00 21.72  ? 713  PHE   A CG  1 
ATOM   3259 C  CD1 . PHE   A 1 450 ? -8.683  -48.335 -28.564 1.00 24.50  ? 713  PHE   A CD1 1 
ATOM   3260 C  CD2 . PHE   A 1 450 ? -10.726 -49.474 -28.914 1.00 24.60  ? 713  PHE   A CD2 1 
ATOM   3261 C  CE1 . PHE   A 1 450 ? -9.372  -47.336 -27.888 1.00 24.91  ? 713  PHE   A CE1 1 
ATOM   3262 C  CE2 . PHE   A 1 450 ? -11.397 -48.491 -28.206 1.00 25.98  ? 713  PHE   A CE2 1 
ATOM   3263 C  CZ  . PHE   A 1 450 ? -10.722 -47.417 -27.722 1.00 24.10  ? 713  PHE   A CZ  1 
ATOM   3264 N  N   . HIS   A 1 451 ? -8.175  -53.904 -29.553 1.00 23.27  ? 714  HIS   A N   1 
ATOM   3265 C  CA  . HIS   A 1 451 ? -7.666  -55.141 -30.174 1.00 22.64  ? 714  HIS   A CA  1 
ATOM   3266 C  C   . HIS   A 1 451 ? -8.321  -55.371 -31.526 1.00 24.59  ? 714  HIS   A C   1 
ATOM   3267 O  O   . HIS   A 1 451 ? -9.538  -55.074 -31.689 1.00 25.81  ? 714  HIS   A O   1 
ATOM   3268 C  CB  . HIS   A 1 451 ? -7.898  -56.319 -29.221 1.00 23.24  ? 714  HIS   A CB  1 
ATOM   3269 C  CG  . HIS   A 1 451 ? -7.150  -56.291 -27.915 1.00 21.89  ? 714  HIS   A CG  1 
ATOM   3270 N  ND1 . HIS   A 1 451 ? -6.033  -57.019 -27.721 1.00 23.26  ? 714  HIS   A ND1 1 
ATOM   3271 C  CD2 . HIS   A 1 451 ? -7.445  -55.738 -26.722 1.00 23.52  ? 714  HIS   A CD2 1 
ATOM   3272 C  CE1 . HIS   A 1 451 ? -5.650  -56.949 -26.443 1.00 24.04  ? 714  HIS   A CE1 1 
ATOM   3273 N  NE2 . HIS   A 1 451 ? -6.501  -56.105 -25.793 1.00 17.54  ? 714  HIS   A NE2 1 
ATOM   3274 N  N   . GLU   A 1 452 ? -7.584  -55.997 -32.448 1.00 25.15  ? 715  GLU   A N   1 
ATOM   3275 C  CA  . GLU   A 1 452 ? -8.150  -56.479 -33.732 1.00 26.57  ? 715  GLU   A CA  1 
ATOM   3276 C  C   . GLU   A 1 452 ? -8.478  -57.967 -33.538 1.00 29.46  ? 715  GLU   A C   1 
ATOM   3277 O  O   . GLU   A 1 452 ? -7.640  -58.697 -33.027 1.00 30.11  ? 715  GLU   A O   1 
ATOM   3278 C  CB  . GLU   A 1 452 ? -7.165  -56.233 -34.880 1.00 31.84  ? 715  GLU   A CB  1 
ATOM   3279 C  CG  . GLU   A 1 452 ? -7.887  -55.837 -36.163 1.00 41.20  ? 715  GLU   A CG  1 
ATOM   3280 C  CD  . GLU   A 1 452 ? -6.966  -55.460 -37.328 1.00 48.51  ? 715  GLU   A CD  1 
ATOM   3281 O  OE1 . GLU   A 1 452 ? -7.365  -54.621 -38.175 1.00 42.94  ? 715  GLU   A OE1 1 
ATOM   3282 O  OE2 . GLU   A 1 452 ? -5.865  -56.052 -37.405 1.00 55.05  ? 715  GLU   A OE2 1 
ATOM   3283 N  N   . LEU   A 1 453 ? -9.724  -58.366 -33.679 1.00 25.39  ? 716  LEU   A N   1 
ATOM   3284 C  CA  . LEU   A 1 453 ? -10.168 -59.737 -33.268 1.00 28.76  ? 716  LEU   A CA  1 
ATOM   3285 C  C   . LEU   A 1 453 ? -10.863 -60.404 -34.451 1.00 33.62  ? 716  LEU   A C   1 
ATOM   3286 O  O   . LEU   A 1 453 ? -11.787 -59.797 -35.029 1.00 31.71  ? 716  LEU   A O   1 
ATOM   3287 C  CB  . LEU   A 1 453 ? -11.082 -59.536 -32.061 1.00 33.03  ? 716  LEU   A CB  1 
ATOM   3288 C  CG  . LEU   A 1 453 ? -11.837 -60.746 -31.558 1.00 38.20  ? 716  LEU   A CG  1 
ATOM   3289 C  CD1 . LEU   A 1 453 ? -10.874 -61.836 -31.117 1.00 41.43  ? 716  LEU   A CD1 1 
ATOM   3290 C  CD2 . LEU   A 1 453 ? -12.745 -60.314 -30.406 1.00 37.19  ? 716  LEU   A CD2 1 
ATOM   3291 N  N   . ILE   A 1 454 ? -10.347 -61.537 -34.909 1.00 31.84  ? 717  ILE   A N   1 
ATOM   3292 C  CA  . ILE   A 1 454 ? -10.842 -62.150 -36.175 1.00 33.11  ? 717  ILE   A CA  1 
ATOM   3293 C  C   . ILE   A 1 454 ? -11.829 -63.270 -35.818 1.00 32.46  ? 717  ILE   A C   1 
ATOM   3294 O  O   . ILE   A 1 454 ? -11.538 -64.050 -34.920 1.00 32.34  ? 717  ILE   A O   1 
ATOM   3295 C  CB  . ILE   A 1 454 ? -9.639  -62.574 -37.039 1.00 44.72  ? 717  ILE   A CB  1 
ATOM   3296 C  CG1 . ILE   A 1 454 ? -8.912  -61.328 -37.580 1.00 43.58  ? 717  ILE   A CG1 1 
ATOM   3297 C  CG2 . ILE   A 1 454 ? -10.067 -63.491 -38.184 1.00 48.84  ? 717  ILE   A CG2 1 
ATOM   3298 C  CD1 . ILE   A 1 454 ? -7.590  -61.658 -38.249 1.00 50.81  ? 717  ILE   A CD1 1 
ATOM   3299 N  N   . MET   A 1 455 ? -13.045 -63.152 -36.320 1.00 29.53  ? 718  MET   A N   1 
ATOM   3300 C  CA  . MET   A 1 455 ? -14.144 -64.118 -36.108 1.00 32.41  ? 718  MET   A CA  1 
ATOM   3301 C  C   . MET   A 1 455 ? -13.822 -65.385 -36.902 1.00 35.86  ? 718  MET   A C   1 
ATOM   3302 O  O   . MET   A 1 455 ? -13.132 -65.302 -37.948 1.00 32.72  ? 718  MET   A O   1 
ATOM   3303 C  CB  . MET   A 1 455 ? -15.469 -63.539 -36.599 1.00 32.42  ? 718  MET   A CB  1 
ATOM   3304 C  CG  . MET   A 1 455 ? -15.906 -62.352 -35.797 1.00 33.90  ? 718  MET   A CG  1 
ATOM   3305 S  SD  . MET   A 1 455 ? -17.444 -61.588 -36.338 1.00 37.82  ? 718  MET   A SD  1 
ATOM   3306 C  CE  . MET   A 1 455 ? -18.600 -62.857 -35.831 1.00 38.39  ? 718  MET   A CE  1 
ATOM   3307 N  N   A LYS   A 1 456 ? -14.322 -66.529 -36.431 0.25 36.98  ? 719  LYS   A N   1 
ATOM   3308 N  N   B LYS   A 1 456 ? -14.320 -66.533 -36.430 0.25 36.87  ? 719  LYS   A N   1 
ATOM   3309 C  CA  A LYS   A 1 456 ? -14.106 -67.854 -37.074 0.25 39.99  ? 719  LYS   A CA  1 
ATOM   3310 C  CA  B LYS   A 1 456 ? -14.099 -67.852 -37.086 0.25 39.76  ? 719  LYS   A CA  1 
ATOM   3311 C  C   A LYS   A 1 456 ? -14.494 -67.776 -38.556 0.25 39.87  ? 719  LYS   A C   1 
ATOM   3312 C  C   B LYS   A 1 456 ? -14.462 -67.744 -38.571 0.25 39.60  ? 719  LYS   A C   1 
ATOM   3313 O  O   A LYS   A 1 456 ? -13.848 -68.467 -39.363 0.25 41.53  ? 719  LYS   A O   1 
ATOM   3314 O  O   B LYS   A 1 456 ? -13.777 -68.383 -39.390 0.25 40.42  ? 719  LYS   A O   1 
ATOM   3315 C  CB  A LYS   A 1 456 ? -14.857 -68.937 -36.293 0.25 41.17  ? 719  LYS   A CB  1 
ATOM   3316 C  CB  B LYS   A 1 456 ? -14.892 -68.964 -36.394 0.25 40.91  ? 719  LYS   A CB  1 
ATOM   3317 C  CG  A LYS   A 1 456 ? -14.060 -69.533 -35.138 0.25 42.59  ? 719  LYS   A CG  1 
ATOM   3318 C  CG  B LYS   A 1 456 ? -14.388 -70.367 -36.708 0.25 42.83  ? 719  LYS   A CG  1 
ATOM   3319 C  CD  A LYS   A 1 456 ? -14.893 -70.320 -34.150 0.25 44.52  ? 719  LYS   A CD  1 
ATOM   3320 C  CD  B LYS   A 1 456 ? -15.049 -71.468 -35.913 0.25 42.55  ? 719  LYS   A CD  1 
ATOM   3321 C  CE  A LYS   A 1 456 ? -15.483 -69.459 -33.054 0.25 43.48  ? 719  LYS   A CE  1 
ATOM   3322 C  CE  B LYS   A 1 456 ? -15.139 -72.767 -36.688 0.25 43.19  ? 719  LYS   A CE  1 
ATOM   3323 N  NZ  A LYS   A 1 456 ? -16.729 -70.054 -32.518 0.25 43.20  ? 719  LYS   A NZ  1 
ATOM   3324 N  NZ  B LYS   A 1 456 ? -14.739 -73.927 -35.854 0.25 43.51  ? 719  LYS   A NZ  1 
ATOM   3325 N  N   . ASP   A 1 457 ? -15.462 -66.922 -38.906 1.00 39.47  ? 720  ASP   A N   1 
ATOM   3326 C  CA  . ASP   A 1 457 ? -15.911 -66.728 -40.310 1.00 38.91  ? 720  ASP   A CA  1 
ATOM   3327 C  C   . ASP   A 1 457 ? -15.080 -65.683 -41.067 1.00 50.98  ? 720  ASP   A C   1 
ATOM   3328 O  O   . ASP   A 1 457 ? -15.530 -65.259 -42.167 1.00 44.96  ? 720  ASP   A O   1 
ATOM   3329 C  CB  . ASP   A 1 457 ? -17.407 -66.374 -40.324 1.00 45.52  ? 720  ASP   A CB  1 
ATOM   3330 C  CG  . ASP   A 1 457 ? -17.799 -65.001 -39.795 1.00 42.81  ? 720  ASP   A CG  1 
ATOM   3331 O  OD1 . ASP   A 1 457 ? -16.939 -64.106 -39.762 1.00 38.71  ? 720  ASP   A OD1 1 
ATOM   3332 O  OD2 . ASP   A 1 457 ? -18.982 -64.838 -39.453 1.00 42.49  ? 720  ASP   A OD2 1 
ATOM   3333 N  N   . GLY   A 1 458 ? -13.959 -65.194 -40.517 1.00 46.77  ? 721  GLY   A N   1 
ATOM   3334 C  CA  . GLY   A 1 458 ? -13.089 -64.276 -41.272 1.00 42.65  ? 721  GLY   A CA  1 
ATOM   3335 C  C   . GLY   A 1 458 ? -13.373 -62.796 -41.042 1.00 41.19  ? 721  GLY   A C   1 
ATOM   3336 O  O   . GLY   A 1 458 ? -12.486 -62.012 -41.354 1.00 47.57  ? 721  GLY   A O   1 
ATOM   3337 N  N   . ARG   A 1 459 ? -14.533 -62.382 -40.526 1.00 35.84  ? 722  ARG   A N   1 
ATOM   3338 C  CA  . ARG   A 1 459 ? -14.843 -60.938 -40.436 1.00 32.13  ? 722  ARG   A CA  1 
ATOM   3339 C  C   . ARG   A 1 459 ? -14.053 -60.345 -39.247 1.00 35.54  ? 722  ARG   A C   1 
ATOM   3340 O  O   . ARG   A 1 459 ? -13.651 -61.106 -38.333 1.00 35.88  ? 722  ARG   A O   1 
ATOM   3341 C  CB  . ARG   A 1 459 ? -16.335 -60.655 -40.326 1.00 36.12  ? 722  ARG   A CB  1 
ATOM   3342 C  CG  . ARG   A 1 459 ? -17.181 -61.147 -41.506 1.00 36.34  ? 722  ARG   A CG  1 
ATOM   3343 C  CD  . ARG   A 1 459 ? -18.652 -60.865 -41.307 1.00 37.04  ? 722  ARG   A CD  1 
ATOM   3344 N  NE  . ARG   A 1 459 ? -19.272 -61.775 -40.371 1.00 35.06  ? 722  ARG   A NE  1 
ATOM   3345 C  CZ  . ARG   A 1 459 ? -20.554 -61.772 -40.082 1.00 31.46  ? 722  ARG   A CZ  1 
ATOM   3346 N  NH1 . ARG   A 1 459 ? -21.347 -60.850 -40.585 1.00 33.99  ? 722  ARG   A NH1 1 
ATOM   3347 N  NH2 . ARG   A 1 459 ? -21.041 -62.637 -39.217 1.00 34.59  ? 722  ARG   A NH2 1 
ATOM   3348 N  N   . VAL   A 1 460 ? -13.789 -59.048 -39.309 1.00 34.14  ? 723  VAL   A N   1 
ATOM   3349 C  CA  . VAL   A 1 460 ? -12.879 -58.352 -38.349 1.00 35.34  ? 723  VAL   A CA  1 
ATOM   3350 C  C   . VAL   A 1 460 ? -13.642 -57.454 -37.390 1.00 32.50  ? 723  VAL   A C   1 
ATOM   3351 O  O   . VAL   A 1 460 ? -14.337 -56.518 -37.826 1.00 39.58  ? 723  VAL   A O   1 
ATOM   3352 C  CB  . VAL   A 1 460 ? -11.784 -57.574 -39.083 1.00 37.70  ? 723  VAL   A CB  1 
ATOM   3353 C  CG1 . VAL   A 1 460 ? -10.837 -56.917 -38.078 1.00 38.20  ? 723  VAL   A CG1 1 
ATOM   3354 C  CG2 . VAL   A 1 460 ? -11.021 -58.514 -40.003 1.00 37.82  ? 723  VAL   A CG2 1 
ATOM   3355 N  N   . LEU   A 1 461 ? -13.448 -57.687 -36.085 1.00 26.84  ? 724  LEU   A N   1 
ATOM   3356 C  CA  . LEU   A 1 461 ? -13.962 -56.773 -35.047 1.00 24.28  ? 724  LEU   A CA  1 
ATOM   3357 C  C   . LEU   A 1 461 ? -12.785 -55.943 -34.479 1.00 26.79  ? 724  LEU   A C   1 
ATOM   3358 O  O   . LEU   A 1 461 ? -11.671 -56.501 -34.272 1.00 28.65  ? 724  LEU   A O   1 
ATOM   3359 C  CB  . LEU   A 1 461 ? -14.614 -57.608 -33.960 1.00 27.18  ? 724  LEU   A CB  1 
ATOM   3360 C  CG  . LEU   A 1 461 ? -15.753 -58.519 -34.388 1.00 27.88  ? 724  LEU   A CG  1 
ATOM   3361 C  CD1 . LEU   A 1 461 ? -15.989 -59.494 -33.273 1.00 30.50  ? 724  LEU   A CD1 1 
ATOM   3362 C  CD2 . LEU   A 1 461 ? -17.006 -57.711 -34.712 1.00 26.54  ? 724  LEU   A CD2 1 
ATOM   3363 N  N   . VAL   A 1 462 ? -12.981 -54.652 -34.280 1.00 23.44  ? 725  VAL   A N   1 
ATOM   3364 C  CA  . VAL   A 1 462 ? -12.052 -53.838 -33.461 1.00 21.58  ? 725  VAL   A CA  1 
ATOM   3365 C  C   . VAL   A 1 462 ? -12.742 -53.540 -32.151 1.00 21.62  ? 725  VAL   A C   1 
ATOM   3366 O  O   . VAL   A 1 462 ? -13.764 -52.849 -32.156 1.00 22.42  ? 725  VAL   A O   1 
ATOM   3367 C  CB  . VAL   A 1 462 ? -11.568 -52.604 -34.212 1.00 24.52  ? 725  VAL   A CB  1 
ATOM   3368 C  CG1 . VAL   A 1 462 ? -10.625 -51.813 -33.301 1.00 25.12  ? 725  VAL   A CG1 1 
ATOM   3369 C  CG2 . VAL   A 1 462 ? -10.916 -53.005 -35.525 1.00 24.67  ? 725  VAL   A CG2 1 
ATOM   3370 N  N   . VAL   A 1 463 ? -12.217 -54.098 -31.062 1.00 20.77  ? 726  VAL   A N   1 
ATOM   3371 C  CA  . VAL   A 1 463 ? -12.898 -54.131 -29.745 1.00 20.89  ? 726  VAL   A CA  1 
ATOM   3372 C  C   . VAL   A 1 463 ? -12.164 -53.301 -28.699 1.00 22.07  ? 726  VAL   A C   1 
ATOM   3373 O  O   . VAL   A 1 463 ? -10.936 -53.223 -28.679 1.00 22.01  ? 726  VAL   A O   1 
ATOM   3374 C  CB  . VAL   A 1 463 ? -13.089 -55.576 -29.280 1.00 23.03  ? 726  VAL   A CB  1 
ATOM   3375 C  CG1 . VAL   A 1 463 ? -13.917 -56.362 -30.296 1.00 25.11  ? 726  VAL   A CG1 1 
ATOM   3376 C  CG2 . VAL   A 1 463 ? -11.771 -56.272 -29.017 1.00 21.81  ? 726  VAL   A CG2 1 
ATOM   3377 N  N   . PRO   A 1 464 ? -12.933 -52.676 -27.779 1.00 22.12  ? 727  PRO   A N   1 
ATOM   3378 C  CA  . PRO   A 1 464 ? -12.349 -51.911 -26.664 1.00 21.07  ? 727  PRO   A CA  1 
ATOM   3379 C  C   . PRO   A 1 464 ? -11.887 -52.797 -25.509 1.00 20.34  ? 727  PRO   A C   1 
ATOM   3380 O  O   . PRO   A 1 464 ? -12.533 -53.856 -25.245 1.00 20.04  ? 727  PRO   A O   1 
ATOM   3381 C  CB  . PRO   A 1 464 ? -13.522 -51.053 -26.221 1.00 20.57  ? 727  PRO   A CB  1 
ATOM   3382 C  CG  . PRO   A 1 464 ? -14.756 -51.936 -26.506 1.00 21.20  ? 727  PRO   A CG  1 
ATOM   3383 C  CD  . PRO   A 1 464 ? -14.400 -52.613 -27.817 1.00 21.77  ? 727  PRO   A CD  1 
ATOM   3384 N  N   . CYS   A 1 465 ? -10.859 -52.359 -24.779 1.00 19.61  ? 728  CYS   A N   1 
ATOM   3385 C  CA  . CYS   A 1 465 ? -10.268 -53.220 -23.715 1.00 19.72  ? 728  CYS   A CA  1 
ATOM   3386 C  C   . CYS   A 1 465 ? -9.613  -52.334 -22.666 1.00 22.04  ? 728  CYS   A C   1 
ATOM   3387 O  O   . CYS   A 1 465 ? -9.136  -51.258 -23.007 1.00 21.53  ? 728  CYS   A O   1 
ATOM   3388 C  CB  . CYS   A 1 465 ? -9.266  -54.230 -24.286 1.00 21.94  ? 728  CYS   A CB  1 
ATOM   3389 S  SG  . CYS   A 1 465 ? -8.811  -55.573 -23.134 1.00 20.98  ? 728  CYS   A SG  1 
ATOM   3390 N  N   . ARG   A 1 466 ? -9.591  -52.796 -21.425 1.00 22.66  ? 729  ARG   A N   1 
ATOM   3391 C  CA  . ARG   A 1 466 ? -8.721  -52.194 -20.409 1.00 24.52  ? 729  ARG   A CA  1 
ATOM   3392 C  C   . ARG   A 1 466 ? -8.452  -53.249 -19.358 1.00 21.55  ? 729  ARG   A C   1 
ATOM   3393 O  O   . ARG   A 1 466 ? -9.061  -54.343 -19.419 1.00 19.85  ? 729  ARG   A O   1 
ATOM   3394 C  CB  . ARG   A 1 466 ? -9.313  -50.949 -19.766 1.00 29.95  ? 729  ARG   A CB  1 
ATOM   3395 C  CG  . ARG   A 1 466 ? -10.626 -51.143 -19.067 1.00 32.17  ? 729  ARG   A CG  1 
ATOM   3396 C  CD  . ARG   A 1 466 ? -11.358 -49.814 -18.823 1.00 29.81  ? 729  ARG   A CD  1 
ATOM   3397 N  NE  . ARG   A 1 466 ? -10.764 -49.027 -17.774 1.00 28.66  ? 729  ARG   A NE  1 
ATOM   3398 C  CZ  . ARG   A 1 466 ? -11.282 -47.888 -17.300 1.00 31.29  ? 729  ARG   A CZ  1 
ATOM   3399 N  NH1 . ARG   A 1 466 ? -12.457 -47.435 -17.709 1.00 33.18  ? 729  ARG   A NH1 1 
ATOM   3400 N  NH2 . ARG   A 1 466 ? -10.611 -47.231 -16.396 1.00 33.25  ? 729  ARG   A NH2 1 
ATOM   3401 N  N   . ASN   A 1 467 ? -7.514  -52.959 -18.489 1.00 21.54  ? 730  ASN   A N   1 
ATOM   3402 C  CA  . ASN   A 1 467 ? -7.127  -53.960 -17.465 1.00 23.35  ? 730  ASN   A CA  1 
ATOM   3403 C  C   . ASN   A 1 467 ? -8.415  -54.431 -16.750 1.00 21.77  ? 730  ASN   A C   1 
ATOM   3404 O  O   . ASN   A 1 467 ? -9.172  -53.607 -16.219 1.00 19.78  ? 730  ASN   A O   1 
ATOM   3405 C  CB  . ASN   A 1 467 ? -6.095  -53.384 -16.508 1.00 25.05  ? 730  ASN   A CB  1 
ATOM   3406 C  CG  . ASN   A 1 467 ? -5.768  -54.421 -15.467 1.00 28.21  ? 730  ASN   A CG  1 
ATOM   3407 O  OD1 . ASN   A 1 467 ? -6.462  -54.500 -14.477 1.00 29.01  ? 730  ASN   A OD1 1 
ATOM   3408 N  ND2 . ASN   A 1 467 ? -4.836  -55.323 -15.787 1.00 32.13  ? 730  ASN   A ND2 1 
ATOM   3409 N  N   . GLN   A 1 468 ? -8.582  -55.739 -16.606 1.00 21.86  ? 731  GLN   A N   1 
ATOM   3410 C  CA  . GLN   A 1 468 ? -9.851  -56.342 -16.147 1.00 22.25  ? 731  GLN   A CA  1 
ATOM   3411 C  C   . GLN   A 1 468 ? -10.077 -56.021 -14.671 1.00 22.80  ? 731  GLN   A C   1 
ATOM   3412 O  O   . GLN   A 1 468 ? -11.269 -55.877 -14.244 1.00 21.25  ? 731  GLN   A O   1 
ATOM   3413 C  CB  . GLN   A 1 468 ? -9.863  -57.822 -16.438 1.00 25.01  ? 731  GLN   A CB  1 
ATOM   3414 C  CG  . GLN   A 1 468 ? -11.238 -58.431 -16.271 1.00 23.53  ? 731  GLN   A CG  1 
ATOM   3415 C  CD  . GLN   A 1 468 ? -11.208 -59.925 -16.467 1.00 24.23  ? 731  GLN   A CD  1 
ATOM   3416 O  OE1 . GLN   A 1 468 ? -11.548 -60.411 -17.531 1.00 23.42  ? 731  GLN   A OE1 1 
ATOM   3417 N  NE2 . GLN   A 1 468 ? -10.916 -60.666 -15.405 1.00 21.64  ? 731  GLN   A NE2 1 
ATOM   3418 N  N   . ASP   A 1 469 ? -9.010  -55.825 -13.903 1.00 22.08  ? 732  ASP   A N   1 
ATOM   3419 C  CA  . ASP   A 1 469 ? -9.191  -55.419 -12.475 1.00 24.71  ? 732  ASP   A CA  1 
ATOM   3420 C  C   . ASP   A 1 469 ? -9.957  -54.095 -12.401 1.00 24.03  ? 732  ASP   A C   1 
ATOM   3421 O  O   . ASP   A 1 469 ? -10.764 -53.868 -11.442 1.00 23.83  ? 732  ASP   A O   1 
ATOM   3422 C  CB  . ASP   A 1 469 ? -7.850  -55.290 -11.749 1.00 25.16  ? 732  ASP   A CB  1 
ATOM   3423 C  CG  . ASP   A 1 469 ? -7.125  -56.615 -11.533 1.00 28.87  ? 732  ASP   A CG  1 
ATOM   3424 O  OD1 . ASP   A 1 469 ? -7.756  -57.684 -11.628 1.00 25.72  ? 732  ASP   A OD1 1 
ATOM   3425 O  OD2 . ASP   A 1 469 ? -5.918  -56.547 -11.211 1.00 30.03  ? 732  ASP   A OD2 1 
ATOM   3426 N  N   . GLU   A 1 470 ? -9.695  -53.158 -13.326 1.00 23.42  ? 733  GLU   A N   1 
ATOM   3427 C  CA  . GLU   A 1 470 ? -10.376 -51.837 -13.324 1.00 23.43  ? 733  GLU   A CA  1 
ATOM   3428 C  C   . GLU   A 1 470 ? -11.869 -52.026 -13.606 1.00 21.01  ? 733  GLU   A C   1 
ATOM   3429 O  O   . GLU   A 1 470 ? -12.713 -51.336 -12.959 1.00 22.77  ? 733  GLU   A O   1 
ATOM   3430 C  CB  . GLU   A 1 470 ? -9.810  -50.912 -14.396 1.00 26.31  ? 733  GLU   A CB  1 
ATOM   3431 C  CG  . GLU   A 1 470 ? -8.337  -50.594 -14.215 1.00 31.58  ? 733  GLU   A CG  1 
ATOM   3432 C  CD  . GLU   A 1 470 ? -7.716  -49.807 -15.378 1.00 36.70  ? 733  GLU   A CD  1 
ATOM   3433 O  OE1 . GLU   A 1 470 ? -6.499  -49.747 -15.410 1.00 41.99  ? 733  GLU   A OE1 1 
ATOM   3434 O  OE2 . GLU   A 1 470 ? -8.444  -49.274 -16.262 1.00 33.40  ? 733  GLU   A OE2 1 
ATOM   3435 N  N   . LEU   A 1 471 ? -12.218 -52.911 -14.532 1.00 21.43  ? 734  LEU   A N   1 
ATOM   3436 C  CA  . LEU   A 1 471 ? -13.626 -53.157 -14.938 1.00 21.34  ? 734  LEU   A CA  1 
ATOM   3437 C  C   . LEU   A 1 471 ? -14.400 -53.788 -13.771 1.00 20.69  ? 734  LEU   A C   1 
ATOM   3438 O  O   . LEU   A 1 471 ? -15.534 -53.304 -13.420 1.00 21.13  ? 734  LEU   A O   1 
ATOM   3439 C  CB  . LEU   A 1 471 ? -13.629 -54.020 -16.189 1.00 21.58  ? 734  LEU   A CB  1 
ATOM   3440 C  CG  . LEU   A 1 471 ? -13.116 -53.297 -17.437 1.00 23.81  ? 734  LEU   A CG  1 
ATOM   3441 C  CD1 . LEU   A 1 471 ? -13.025 -54.253 -18.596 1.00 22.69  ? 734  LEU   A CD1 1 
ATOM   3442 C  CD2 . LEU   A 1 471 ? -14.026 -52.136 -17.824 1.00 23.79  ? 734  LEU   A CD2 1 
ATOM   3443 N  N   . ILE   A 1 472 ? -13.824 -54.812 -13.166 1.00 23.10  ? 735  ILE   A N   1 
ATOM   3444 C  CA  . ILE   A 1 472 ? -14.503 -55.548 -12.061 1.00 21.94  ? 735  ILE   A CA  1 
ATOM   3445 C  C   . ILE   A 1 472 ? -14.599 -54.653 -10.829 1.00 20.54  ? 735  ILE   A C   1 
ATOM   3446 O  O   . ILE   A 1 472 ? -15.670 -54.640 -10.197 1.00 21.65  ? 735  ILE   A O   1 
ATOM   3447 C  CB  . ILE   A 1 472 ? -13.780 -56.847 -11.765 1.00 21.07  ? 735  ILE   A CB  1 
ATOM   3448 C  CG1 . ILE   A 1 472 ? -13.957 -57.752 -12.980 1.00 23.68  ? 735  ILE   A CG1 1 
ATOM   3449 C  CG2 . ILE   A 1 472 ? -14.259 -57.444 -10.434 1.00 21.65  ? 735  ILE   A CG2 1 
ATOM   3450 C  CD1 . ILE   A 1 472 ? -13.301 -59.058 -12.859 1.00 27.18  ? 735  ILE   A CD1 1 
ATOM   3451 N  N   . GLY   A 1 473 ? -13.539 -53.938 -10.518 1.00 20.57  ? 736  GLY   A N   1 
ATOM   3452 C  CA  . GLY   A 1 473 ? -13.543 -53.039 -9.350  1.00 22.08  ? 736  GLY   A CA  1 
ATOM   3453 C  C   . GLY   A 1 473 ? -14.562 -51.903 -9.497  1.00 25.48  ? 736  GLY   A C   1 
ATOM   3454 O  O   . GLY   A 1 473 ? -15.232 -51.559 -8.495  1.00 22.45  ? 736  GLY   A O   1 
ATOM   3455 N  N   . ARG   A 1 474 ? -14.748 -51.346 -10.695 1.00 23.05  ? 737  ARG   A N   1 
ATOM   3456 C  CA  . ARG   A 1 474 ? -15.765 -50.258 -10.896 1.00 23.40  ? 737  ARG   A CA  1 
ATOM   3457 C  C   . ARG   A 1 474 ? -17.192 -50.833 -10.774 1.00 23.83  ? 737  ARG   A C   1 
ATOM   3458 O  O   . ARG   A 1 474 ? -18.072 -50.183 -10.198 1.00 24.58  ? 737  ARG   A O   1 
ATOM   3459 C  CB  . ARG   A 1 474 ? -15.584 -49.648 -12.306 1.00 26.93  ? 737  ARG   A CB  1 
ATOM   3460 C  CG  . ARG   A 1 474 ? -14.204 -49.047 -12.537 1.00 38.26  ? 737  ARG   A CG  1 
ATOM   3461 C  CD  . ARG   A 1 474 ? -13.868 -48.848 -14.028 1.00 49.56  ? 737  ARG   A CD  1 
ATOM   3462 N  NE  . ARG   A 1 474 ? -14.376 -47.525 -14.357 1.00 52.76  ? 737  ARG   A NE  1 
ATOM   3463 C  CZ  . ARG   A 1 474 ? -13.809 -46.382 -13.969 1.00 56.04  ? 737  ARG   A CZ  1 
ATOM   3464 N  NH1 . ARG   A 1 474 ? -14.374 -45.235 -14.310 1.00 62.16  ? 737  ARG   A NH1 1 
ATOM   3465 N  NH2 . ARG   A 1 474 ? -12.691 -46.384 -13.256 1.00 53.43  ? 737  ARG   A NH2 1 
ATOM   3466 N  N   . ALA   A 1 475 ? -17.470 -52.013 -11.332 1.00 21.45  ? 738  ALA   A N   1 
ATOM   3467 C  CA  . ALA   A 1 475 ? -18.813 -52.652 -11.302 1.00 21.77  ? 738  ALA   A CA  1 
ATOM   3468 C  C   . ALA   A 1 475 ? -19.206 -53.035 -9.863  1.00 27.36  ? 738  ALA   A C   1 
ATOM   3469 O  O   . ALA   A 1 475 ? -20.416 -53.092 -9.602  1.00 25.35  ? 738  ALA   A O   1 
ATOM   3470 C  CB  . ALA   A 1 475 ? -18.840 -53.848 -12.212 1.00 21.49  ? 738  ALA   A CB  1 
ATOM   3471 N  N   . ARG   A 1 476 ? -18.236 -53.171 -8.937  1.00 21.78  ? 739  ARG   A N   1 
ATOM   3472 C  CA  . ARG   A 1 476 ? -18.533 -53.526 -7.520  1.00 23.25  ? 739  ARG   A CA  1 
ATOM   3473 C  C   . ARG   A 1 476 ? -18.865 -52.287 -6.678  1.00 27.01  ? 739  ARG   A C   1 
ATOM   3474 O  O   . ARG   A 1 476 ? -19.180 -52.441 -5.469  1.00 24.74  ? 739  ARG   A O   1 
ATOM   3475 C  CB  . ARG   A 1 476 ? -17.388 -54.348 -6.917  1.00 22.72  ? 739  ARG   A CB  1 
ATOM   3476 C  CG  . ARG   A 1 476 ? -17.351 -55.731 -7.537  1.00 22.91  ? 739  ARG   A CG  1 
ATOM   3477 C  CD  . ARG   A 1 476 ? -16.067 -56.554 -7.344  1.00 24.99  ? 739  ARG   A CD  1 
ATOM   3478 N  NE  . ARG   A 1 476 ? -15.623 -56.716 -5.994  1.00 24.72  ? 739  ARG   A NE  1 
ATOM   3479 C  CZ  . ARG   A 1 476 ? -15.275 -57.859 -5.406  1.00 22.53  ? 739  ARG   A CZ  1 
ATOM   3480 N  NH1 . ARG   A 1 476 ? -15.488 -59.030 -5.941  1.00 24.21  ? 739  ARG   A NH1 1 
ATOM   3481 N  NH2 . ARG   A 1 476 ? -14.748 -57.815 -4.213  1.00 24.23  ? 739  ARG   A NH2 1 
ATOM   3482 N  N   . ILE   A 1 477 ? -18.873 -51.110 -7.291  1.00 26.10  ? 740  ILE   A N   1 
ATOM   3483 C  CA  . ILE   A 1 477 ? -19.092 -49.843 -6.567  1.00 33.76  ? 740  ILE   A CA  1 
ATOM   3484 C  C   . ILE   A 1 477 ? -20.412 -49.222 -7.015  1.00 36.34  ? 740  ILE   A C   1 
ATOM   3485 O  O   . ILE   A 1 477 ? -20.761 -49.264 -8.219  1.00 33.04  ? 740  ILE   A O   1 
ATOM   3486 C  CB  . ILE   A 1 477 ? -17.924 -48.859 -6.793  1.00 34.38  ? 740  ILE   A CB  1 
ATOM   3487 C  CG1 . ILE   A 1 477 ? -16.671 -49.363 -6.079  1.00 34.74  ? 740  ILE   A CG1 1 
ATOM   3488 C  CG2 . ILE   A 1 477 ? -18.326 -47.456 -6.333  1.00 40.38  ? 740  ILE   A CG2 1 
ATOM   3489 C  CD1 . ILE   A 1 477 ? -15.430 -48.585 -6.422  1.00 39.53  ? 740  ILE   A CD1 1 
ATOM   3490 N  N   A SER   A 1 478 ? -21.140 -48.684 -6.041  0.25 38.12  ? 741  SER   A N   1 
ATOM   3491 N  N   B SER   A 1 478 ? -21.154 -48.666 -6.056  0.25 39.25  ? 741  SER   A N   1 
ATOM   3492 C  CA  A SER   A 1 478 ? -22.320 -47.803 -6.232  0.25 42.93  ? 741  SER   A CA  1 
ATOM   3493 C  CA  B SER   A 1 478 ? -22.350 -47.810 -6.296  0.25 44.65  ? 741  SER   A CA  1 
ATOM   3494 C  C   A SER   A 1 478 ? -22.007 -46.435 -5.621  0.25 46.67  ? 741  SER   A C   1 
ATOM   3495 C  C   B SER   A 1 478 ? -22.251 -46.538 -5.446  0.25 47.99  ? 741  SER   A C   1 
ATOM   3496 O  O   A SER   A 1 478 ? -20.992 -46.312 -4.884  0.25 44.87  ? 741  SER   A O   1 
ATOM   3497 O  O   B SER   A 1 478 ? -21.630 -46.583 -4.356  0.25 47.29  ? 741  SER   A O   1 
ATOM   3498 C  CB  A SER   A 1 478 ? -23.550 -48.433 -5.623  0.25 42.46  ? 741  SER   A CB  1 
ATOM   3499 C  CB  B SER   A 1 478 ? -23.637 -48.566 -6.044  0.25 45.15  ? 741  SER   A CB  1 
ATOM   3500 O  OG  A SER   A 1 478 ? -24.672 -47.568 -5.702  0.25 40.48  ? 741  SER   A OG  1 
ATOM   3501 O  OG  B SER   A 1 478 ? -23.657 -49.174 -4.757  0.25 45.39  ? 741  SER   A OG  1 
ATOM   3502 N  N   . GLN   A 1 479 ? -22.832 -45.439 -5.930  0.50 54.62  ? 742  GLN   A N   1 
ATOM   3503 C  CA  . GLN   A 1 479 ? -22.755 -44.087 -5.320  0.50 59.95  ? 742  GLN   A CA  1 
ATOM   3504 C  C   . GLN   A 1 479 ? -24.146 -43.714 -4.799  0.50 58.83  ? 742  GLN   A C   1 
ATOM   3505 O  O   . GLN   A 1 479 ? -25.125 -44.011 -5.504  0.50 54.07  ? 742  GLN   A O   1 
ATOM   3506 C  CB  . GLN   A 1 479 ? -22.241 -43.075 -6.347  0.50 65.61  ? 742  GLN   A CB  1 
ATOM   3507 C  CG  . GLN   A 1 479 ? -20.886 -43.445 -6.937  0.50 72.89  ? 742  GLN   A CG  1 
ATOM   3508 C  CD  . GLN   A 1 479 ? -19.759 -43.306 -5.941  0.50 77.38  ? 742  GLN   A CD  1 
ATOM   3509 O  OE1 . GLN   A 1 479 ? -19.805 -42.480 -5.030  0.50 79.58  ? 742  GLN   A OE1 1 
ATOM   3510 N  NE2 . GLN   A 1 479 ? -18.727 -44.119 -6.110  0.50 79.80  ? 742  GLN   A NE2 1 
ATOM   3511 N  N   . GLY   A 1 480 ? -24.215 -43.117 -3.605  0.50 59.22  ? 743  GLY   A N   1 
ATOM   3512 C  CA  . GLY   A 1 480 ? -25.458 -42.574 -3.021  0.50 60.08  ? 743  GLY   A CA  1 
ATOM   3513 C  C   . GLY   A 1 480 ? -26.102 -43.518 -2.018  0.50 57.37  ? 743  GLY   A C   1 
ATOM   3514 O  O   . GLY   A 1 480 ? -25.677 -44.686 -1.930  0.50 53.66  ? 743  GLY   A O   1 
ATOM   3515 N  N   . ALA   A 1 481 ? -27.111 -43.017 -1.296  1.00 58.03  ? 744  ALA   A N   1 
ATOM   3516 C  CA  . ALA   A 1 481 ? -27.830 -43.744 -0.226  1.00 56.59  ? 744  ALA   A CA  1 
ATOM   3517 C  C   . ALA   A 1 481 ? -29.199 -44.242 -0.707  1.00 51.43  ? 744  ALA   A C   1 
ATOM   3518 O  O   . ALA   A 1 481 ? -29.649 -43.825 -1.775  1.00 46.05  ? 744  ALA   A O   1 
ATOM   3519 C  CB  . ALA   A 1 481 ? -27.979 -42.814 0.963   1.00 58.32  ? 744  ALA   A CB  1 
ATOM   3520 N  N   . GLY   A 1 482 ? -29.823 -45.101 0.099   1.00 41.73  ? 745  GLY   A N   1 
ATOM   3521 C  CA  . GLY   A 1 482 ? -31.226 -45.545 -0.016  1.00 41.11  ? 745  GLY   A CA  1 
ATOM   3522 C  C   . GLY   A 1 482 ? -31.410 -46.534 -1.150  1.00 39.45  ? 745  GLY   A C   1 
ATOM   3523 O  O   . GLY   A 1 482 ? -32.501 -46.542 -1.728  1.00 42.47  ? 745  GLY   A O   1 
ATOM   3524 N  N   . TRP   A 1 483 ? -30.378 -47.302 -1.535  1.00 30.57  ? 746  TRP   A N   1 
ATOM   3525 C  CA  . TRP   A 1 483 ? -30.559 -48.311 -2.609  1.00 33.92  ? 746  TRP   A CA  1 
ATOM   3526 C  C   . TRP   A 1 483 ? -31.342 -49.508 -2.060  1.00 31.33  ? 746  TRP   A C   1 
ATOM   3527 O  O   . TRP   A 1 483 ? -30.909 -50.192 -1.138  1.00 29.38  ? 746  TRP   A O   1 
ATOM   3528 C  CB  . TRP   A 1 483 ? -29.249 -48.761 -3.248  1.00 40.21  ? 746  TRP   A CB  1 
ATOM   3529 C  CG  . TRP   A 1 483 ? -28.499 -47.737 -4.035  1.00 44.98  ? 746  TRP   A CG  1 
ATOM   3530 C  CD1 . TRP   A 1 483 ? -27.764 -46.706 -3.523  1.00 56.49  ? 746  TRP   A CD1 1 
ATOM   3531 C  CD2 . TRP   A 1 483 ? -28.291 -47.708 -5.460  1.00 42.98  ? 746  TRP   A CD2 1 
ATOM   3532 N  NE1 . TRP   A 1 483 ? -27.174 -45.992 -4.533  1.00 54.46  ? 746  TRP   A NE1 1 
ATOM   3533 C  CE2 . TRP   A 1 483 ? -27.480 -46.582 -5.734  1.00 53.21  ? 746  TRP   A CE2 1 
ATOM   3534 C  CE3 . TRP   A 1 483 ? -28.728 -48.498 -6.527  1.00 39.03  ? 746  TRP   A CE3 1 
ATOM   3535 C  CZ2 . TRP   A 1 483 ? -27.099 -46.238 -7.034  1.00 47.78  ? 746  TRP   A CZ2 1 
ATOM   3536 C  CZ3 . TRP   A 1 483 ? -28.365 -48.152 -7.807  1.00 40.74  ? 746  TRP   A CZ3 1 
ATOM   3537 C  CH2 . TRP   A 1 483 ? -27.575 -47.030 -8.057  1.00 46.59  ? 746  TRP   A CH2 1 
ATOM   3538 N  N   . SER   A 1 484 ? -32.472 -49.813 -2.658  1.00 28.74  ? 747  SER   A N   1 
ATOM   3539 C  CA  . SER   A 1 484 ? -33.156 -51.097 -2.388  1.00 26.47  ? 747  SER   A CA  1 
ATOM   3540 C  C   . SER   A 1 484 ? -32.318 -52.245 -2.947  1.00 23.64  ? 747  SER   A C   1 
ATOM   3541 O  O   . SER   A 1 484 ? -31.444 -51.944 -3.782  1.00 24.65  ? 747  SER   A O   1 
ATOM   3542 C  CB  . SER   A 1 484 ? -34.549 -51.057 -2.966  1.00 28.67  ? 747  SER   A CB  1 
ATOM   3543 O  OG  . SER   A 1 484 ? -34.515 -51.153 -4.372  1.00 26.46  ? 747  SER   A OG  1 
ATOM   3544 N  N   . LEU   A 1 485 ? -32.646 -53.505 -2.609  1.00 24.41  ? 748  LEU   A N   1 
ATOM   3545 C  CA  . LEU   A 1 485 ? -32.005 -54.686 -3.238  1.00 27.16  ? 748  LEU   A CA  1 
ATOM   3546 C  C   . LEU   A 1 485 ? -32.360 -54.732 -4.742  1.00 28.11  ? 748  LEU   A C   1 
ATOM   3547 O  O   . LEU   A 1 485 ? -31.477 -55.016 -5.592  1.00 24.10  ? 748  LEU   A O   1 
ATOM   3548 C  CB  . LEU   A 1 485 ? -32.474 -55.957 -2.531  1.00 26.32  ? 748  LEU   A CB  1 
ATOM   3549 C  CG  . LEU   A 1 485 ? -31.902 -57.243 -3.086  1.00 30.21  ? 748  LEU   A CG  1 
ATOM   3550 C  CD1 . LEU   A 1 485 ? -30.386 -57.169 -3.163  1.00 31.32  ? 748  LEU   A CD1 1 
ATOM   3551 C  CD2 . LEU   A 1 485 ? -32.334 -58.450 -2.248  1.00 29.98  ? 748  LEU   A CD2 1 
ATOM   3552 N  N   . ARG   A 1 486 ? -33.607 -54.406 -5.105  1.00 26.16  ? 749  ARG   A N   1 
ATOM   3553 C  CA  . ARG   A 1 486 ? -33.987 -54.334 -6.541  1.00 25.61  ? 749  ARG   A CA  1 
ATOM   3554 C  C   . ARG   A 1 486 ? -33.131 -53.312 -7.286  1.00 24.79  ? 749  ARG   A C   1 
ATOM   3555 O  O   . ARG   A 1 486 ? -32.701 -53.625 -8.394  1.00 24.87  ? 749  ARG   A O   1 
ATOM   3556 C  CB  . ARG   A 1 486 ? -35.474 -54.013 -6.702  1.00 29.13  ? 749  ARG   A CB  1 
ATOM   3557 C  CG  . ARG   A 1 486 ? -35.891 -53.727 -8.139  1.00 31.01  ? 749  ARG   A CG  1 
ATOM   3558 C  CD  . ARG   A 1 486 ? -37.418 -53.858 -8.207  1.00 32.29  ? 749  ARG   A CD  1 
ATOM   3559 N  NE  . ARG   A 1 486 ? -37.961 -53.771 -9.571  1.00 29.34  ? 749  ARG   A NE  1 
ATOM   3560 C  CZ  . ARG   A 1 486 ? -39.111 -54.306 -9.911  1.00 32.16  ? 749  ARG   A CZ  1 
ATOM   3561 N  NH1 . ARG   A 1 486 ? -39.816 -54.970 -8.993  1.00 30.49  ? 749  ARG   A NH1 1 
ATOM   3562 N  NH2 . ARG   A 1 486 ? -39.537 -54.218 -11.158 1.00 31.34  ? 749  ARG   A NH2 1 
ATOM   3563 N  N   . GLU   A 1 487 ? -32.971 -52.099 -6.769  1.00 25.86  ? 750  GLU   A N   1 
ATOM   3564 C  CA  . GLU   A 1 487 ? -32.211 -51.046 -7.460  1.00 27.57  ? 750  GLU   A CA  1 
ATOM   3565 C  C   . GLU   A 1 487 ? -30.742 -51.504 -7.574  1.00 26.75  ? 750  GLU   A C   1 
ATOM   3566 O  O   . GLU   A 1 487 ? -30.121 -51.280 -8.632  1.00 22.72  ? 750  GLU   A O   1 
ATOM   3567 C  CB  . GLU   A 1 487 ? -32.264 -49.711 -6.711  1.00 35.31  ? 750  GLU   A CB  1 
ATOM   3568 C  CG  . GLU   A 1 487 ? -32.144 -48.529 -7.650  1.00 44.33  ? 750  GLU   A CG  1 
ATOM   3569 C  CD  . GLU   A 1 487 ? -31.946 -47.135 -7.060  1.00 55.41  ? 750  GLU   A CD  1 
ATOM   3570 O  OE1 . GLU   A 1 487 ? -32.174 -46.956 -5.817  1.00 53.63  ? 750  GLU   A OE1 1 
ATOM   3571 O  OE2 . GLU   A 1 487 ? -31.585 -46.213 -7.865  1.00 46.42  ? 750  GLU   A OE2 1 
ATOM   3572 N  N   . THR   A 1 488 ? -30.197 -52.122 -6.524  1.00 24.80  ? 751  THR   A N   1 
ATOM   3573 C  CA  . THR   A 1 488 ? -28.783 -52.616 -6.565  1.00 22.91  ? 751  THR   A CA  1 
ATOM   3574 C  C   . THR   A 1 488 ? -28.654 -53.695 -7.645  1.00 22.44  ? 751  THR   A C   1 
ATOM   3575 O  O   . THR   A 1 488 ? -27.622 -53.711 -8.445  1.00 24.37  ? 751  THR   A O   1 
ATOM   3576 C  CB  . THR   A 1 488 ? -28.383 -53.172 -5.208  1.00 25.51  ? 751  THR   A CB  1 
ATOM   3577 O  OG1 . THR   A 1 488 ? -28.615 -52.136 -4.253  1.00 25.64  ? 751  THR   A OG1 1 
ATOM   3578 C  CG2 . THR   A 1 488 ? -26.953 -53.666 -5.200  1.00 24.67  ? 751  THR   A CG2 1 
ATOM   3579 N  N   . ALA   A 1 489 ? -29.593 -54.646 -7.685  1.00 22.27  ? 752  ALA   A N   1 
ATOM   3580 C  CA  . ALA   A 1 489 ? -29.597 -55.695 -8.723  1.00 23.02  ? 752  ALA   A CA  1 
ATOM   3581 C  C   . ALA   A 1 489 ? -29.648 -55.078 -10.127 1.00 25.87  ? 752  ALA   A C   1 
ATOM   3582 O  O   . ALA   A 1 489 ? -28.979 -55.621 -11.043 1.00 24.28  ? 752  ALA   A O   1 
ATOM   3583 C  CB  . ALA   A 1 489 ? -30.742 -56.668 -8.490  1.00 23.06  ? 752  ALA   A CB  1 
ATOM   3584 N  N   . CYS   A 1 490 ? -30.499 -54.058 -10.338 1.00 23.01  ? 753  CYS   A N   1 
ATOM   3585 C  CA  . CYS   A 1 490 ? -30.701 -53.456 -11.689 1.00 22.48  ? 753  CYS   A CA  1 
ATOM   3586 C  C   . CYS   A 1 490 ? -29.402 -52.708 -12.089 1.00 23.23  ? 753  CYS   A C   1 
ATOM   3587 O  O   . CYS   A 1 490 ? -29.047 -52.700 -13.261 1.00 22.93  ? 753  CYS   A O   1 
ATOM   3588 C  CB  . CYS   A 1 490 ? -31.929 -52.546 -11.718 1.00 23.14  ? 753  CYS   A CB  1 
ATOM   3589 S  SG  . CYS   A 1 490 ? -33.476 -53.521 -11.635 1.00 29.26  ? 753  CYS   A SG  1 
ATOM   3590 N  N   . LEU   A 1 491 ? -28.680 -52.095 -11.160 1.00 22.62  ? 754  LEU   A N   1 
ATOM   3591 C  CA  . LEU   A 1 491 ? -27.347 -51.497 -11.487 1.00 23.04  ? 754  LEU   A CA  1 
ATOM   3592 C  C   . LEU   A 1 491 ? -26.316 -52.591 -11.840 1.00 22.77  ? 754  LEU   A C   1 
ATOM   3593 O  O   . LEU   A 1 491 ? -25.552 -52.442 -12.792 1.00 24.37  ? 754  LEU   A O   1 
ATOM   3594 C  CB  . LEU   A 1 491 ? -26.873 -50.662 -10.298 1.00 24.79  ? 754  LEU   A CB  1 
ATOM   3595 C  CG  . LEU   A 1 491 ? -25.496 -50.030 -10.493 1.00 28.73  ? 754  LEU   A CG  1 
ATOM   3596 C  CD1 . LEU   A 1 491 ? -25.492 -49.105 -11.700 1.00 29.48  ? 754  LEU   A CD1 1 
ATOM   3597 C  CD2 . LEU   A 1 491 ? -25.035 -49.301 -9.234  1.00 29.60  ? 754  LEU   A CD2 1 
ATOM   3598 N  N   . GLY   A 1 492 ? -26.347 -53.718 -11.149 1.00 25.11  ? 755  GLY   A N   1 
ATOM   3599 C  CA  . GLY   A 1 492 ? -25.506 -54.861 -11.534 1.00 21.44  ? 755  GLY   A CA  1 
ATOM   3600 C  C   . GLY   A 1 492 ? -25.796 -55.337 -12.923 1.00 24.04  ? 755  GLY   A C   1 
ATOM   3601 O  O   . GLY   A 1 492 ? -24.857 -55.652 -13.689 1.00 21.75  ? 755  GLY   A O   1 
ATOM   3602 N  N   . LYS   A 1 493 ? -27.082 -55.416 -13.278 1.00 21.86  ? 756  LYS   A N   1 
ATOM   3603 C  CA  . LYS   A 1 493 ? -27.496 -55.821 -14.630 1.00 21.77  ? 756  LYS   A CA  1 
ATOM   3604 C  C   . LYS   A 1 493 ? -26.990 -54.830 -15.681 1.00 21.24  ? 756  LYS   A C   1 
ATOM   3605 O  O   . LYS   A 1 493 ? -26.622 -55.321 -16.771 1.00 23.73  ? 756  LYS   A O   1 
ATOM   3606 C  CB  . LYS   A 1 493 ? -29.036 -55.977 -14.671 1.00 25.02  ? 756  LYS   A CB  1 
ATOM   3607 C  CG  . LYS   A 1 493 ? -29.561 -56.523 -15.977 1.00 28.12  ? 756  LYS   A CG  1 
ATOM   3608 C  CD  . LYS   A 1 493 ? -31.024 -56.944 -15.854 1.00 27.55  ? 756  LYS   A CD  1 
ATOM   3609 C  CE  . LYS   A 1 493 ? -31.569 -57.436 -17.165 1.00 29.39  ? 756  LYS   A CE  1 
ATOM   3610 N  NZ  . LYS   A 1 493 ? -32.958 -57.892 -16.965 1.00 29.56  ? 756  LYS   A NZ  1 
ATOM   3611 N  N   . SER   A 1 494 ? -26.986 -53.523 -15.418 1.00 22.53  ? 757  SER   A N   1 
ATOM   3612 C  CA  . SER   A 1 494 ? -26.447 -52.530 -16.372 1.00 25.91  ? 757  SER   A CA  1 
ATOM   3613 C  C   . SER   A 1 494 ? -24.967 -52.869 -16.627 1.00 24.26  ? 757  SER   A C   1 
ATOM   3614 O  O   . SER   A 1 494 ? -24.582 -52.866 -17.801 1.00 22.36  ? 757  SER   A O   1 
ATOM   3615 C  CB  . SER   A 1 494 ? -26.527 -51.067 -15.930 1.00 28.70  ? 757  SER   A CB  1 
ATOM   3616 O  OG  . SER   A 1 494 ? -27.846 -50.683 -15.544 1.00 37.18  ? 757  SER   A OG  1 
ATOM   3617 N  N   . TYR   A 1 495 ? -24.154 -53.112 -15.589 1.00 20.82  ? 758  TYR   A N   1 
ATOM   3618 C  CA  . TYR   A 1 495 ? -22.720 -53.466 -15.807 1.00 22.26  ? 758  TYR   A CA  1 
ATOM   3619 C  C   . TYR   A 1 495 ? -22.620 -54.749 -16.629 1.00 20.40  ? 758  TYR   A C   1 
ATOM   3620 O  O   . TYR   A 1 495 ? -21.783 -54.882 -17.548 1.00 22.66  ? 758  TYR   A O   1 
ATOM   3621 C  CB  . TYR   A 1 495 ? -21.960 -53.567 -14.473 1.00 22.12  ? 758  TYR   A CB  1 
ATOM   3622 C  CG  . TYR   A 1 495 ? -21.490 -52.232 -13.966 1.00 21.50  ? 758  TYR   A CG  1 
ATOM   3623 C  CD1 . TYR   A 1 495 ? -20.348 -51.641 -14.497 1.00 22.45  ? 758  TYR   A CD1 1 
ATOM   3624 C  CD2 . TYR   A 1 495 ? -22.183 -51.535 -12.989 1.00 23.91  ? 758  TYR   A CD2 1 
ATOM   3625 C  CE1 . TYR   A 1 495 ? -19.912 -50.400 -14.085 1.00 23.70  ? 758  TYR   A CE1 1 
ATOM   3626 C  CE2 . TYR   A 1 495 ? -21.717 -50.300 -12.528 1.00 26.64  ? 758  TYR   A CE2 1 
ATOM   3627 C  CZ  . TYR   A 1 495 ? -20.609 -49.716 -13.115 1.00 27.64  ? 758  TYR   A CZ  1 
ATOM   3628 O  OH  . TYR   A 1 495 ? -20.147 -48.486 -12.722 1.00 30.36  ? 758  TYR   A OH  1 
ATOM   3629 N  N   . ALA   A 1 496 ? -23.408 -55.754 -16.295 1.00 20.16  ? 759  ALA   A N   1 
ATOM   3630 C  CA  . ALA   A 1 496 ? -23.364 -57.067 -16.976 1.00 19.95  ? 759  ALA   A CA  1 
ATOM   3631 C  C   . ALA   A 1 496 ? -23.649 -56.882 -18.463 1.00 21.08  ? 759  ALA   A C   1 
ATOM   3632 O  O   . ALA   A 1 496 ? -22.942 -57.480 -19.330 1.00 22.34  ? 759  ALA   A O   1 
ATOM   3633 C  CB  . ALA   A 1 496 ? -24.335 -58.008 -16.318 1.00 21.24  ? 759  ALA   A CB  1 
ATOM   3634 N  N   . GLN   A 1 497 ? -24.697 -56.143 -18.792 1.00 21.67  ? 760  GLN   A N   1 
ATOM   3635 C  CA  . GLN   A 1 497 ? -25.069 -55.960 -20.222 1.00 22.94  ? 760  GLN   A CA  1 
ATOM   3636 C  C   . GLN   A 1 497 ? -23.977 -55.135 -20.946 1.00 20.20  ? 760  GLN   A C   1 
ATOM   3637 O  O   . GLN   A 1 497 ? -23.678 -55.431 -22.149 1.00 22.08  ? 760  GLN   A O   1 
ATOM   3638 C  CB  . GLN   A 1 497 ? -26.486 -55.375 -20.330 1.00 24.74  ? 760  GLN   A CB  1 
ATOM   3639 C  CG  . GLN   A 1 497 ? -27.526 -56.395 -19.835 1.00 25.62  ? 760  GLN   A CG  1 
ATOM   3640 C  CD  . GLN   A 1 497 ? -28.990 -56.199 -20.190 1.00 28.98  ? 760  GLN   A CD  1 
ATOM   3641 O  OE1 . GLN   A 1 497 ? -29.787 -57.151 -20.116 1.00 27.61  ? 760  GLN   A OE1 1 
ATOM   3642 N  NE2 . GLN   A 1 497 ? -29.360 -54.983 -20.496 1.00 27.59  ? 760  GLN   A NE2 1 
ATOM   3643 N  N   . MET   A 1 498 ? -23.367 -54.154 -20.283 1.00 21.18  ? 761  MET   A N   1 
ATOM   3644 C  CA  . MET   A 1 498 ? -22.244 -53.398 -20.906 1.00 21.80  ? 761  MET   A CA  1 
ATOM   3645 C  C   . MET   A 1 498 ? -21.136 -54.386 -21.206 1.00 20.46  ? 761  MET   A C   1 
ATOM   3646 O  O   . MET   A 1 498 ? -20.555 -54.364 -22.312 1.00 20.50  ? 761  MET   A O   1 
ATOM   3647 C  CB  . MET   A 1 498 ? -21.713 -52.252 -20.032 1.00 24.07  ? 761  MET   A CB  1 
ATOM   3648 C  CG  . MET   A 1 498 ? -20.374 -51.581 -20.516 1.00 26.65  ? 761  MET   A CG  1 
ATOM   3649 S  SD  . MET   A 1 498 ? -19.966 -50.254 -19.386 1.00 32.41  ? 761  MET   A SD  1 
ATOM   3650 C  CE  . MET   A 1 498 ? -19.024 -51.241 -18.228 1.00 30.48  ? 761  MET   A CE  1 
ATOM   3651 N  N   . TRP   A 1 499 ? -20.834 -55.254 -20.261 1.00 20.80  ? 762  TRP   A N   1 
ATOM   3652 C  CA  . TRP   A 1 499 ? -19.773 -56.260 -20.468 1.00 20.57  ? 762  TRP   A CA  1 
ATOM   3653 C  C   . TRP   A 1 499 ? -20.083 -57.168 -21.675 1.00 23.54  ? 762  TRP   A C   1 
ATOM   3654 O  O   . TRP   A 1 499 ? -19.180 -57.400 -22.473 1.00 22.74  ? 762  TRP   A O   1 
ATOM   3655 C  CB  . TRP   A 1 499 ? -19.568 -57.075 -19.202 1.00 21.55  ? 762  TRP   A CB  1 
ATOM   3656 C  CG  . TRP   A 1 499 ? -18.896 -56.368 -18.076 1.00 19.48  ? 762  TRP   A CG  1 
ATOM   3657 C  CD1 . TRP   A 1 499 ? -18.395 -55.106 -18.070 1.00 21.66  ? 762  TRP   A CD1 1 
ATOM   3658 C  CD2 . TRP   A 1 499 ? -18.713 -56.874 -16.740 1.00 19.33  ? 762  TRP   A CD2 1 
ATOM   3659 N  NE1 . TRP   A 1 499 ? -17.948 -54.794 -16.819 1.00 21.81  ? 762  TRP   A NE1 1 
ATOM   3660 C  CE2 . TRP   A 1 499 ? -18.099 -55.866 -15.993 1.00 18.33  ? 762  TRP   A CE2 1 
ATOM   3661 C  CE3 . TRP   A 1 499 ? -19.036 -58.058 -16.083 1.00 22.29  ? 762  TRP   A CE3 1 
ATOM   3662 C  CZ2 . TRP   A 1 499 ? -17.727 -56.028 -14.662 1.00 21.55  ? 762  TRP   A CZ2 1 
ATOM   3663 C  CZ3 . TRP   A 1 499 ? -18.703 -58.227 -14.748 1.00 22.67  ? 762  TRP   A CZ3 1 
ATOM   3664 C  CH2 . TRP   A 1 499 ? -18.075 -57.209 -14.040 1.00 22.53  ? 762  TRP   A CH2 1 
ATOM   3665 N  N   A SER   A 1 500 ? -21.320 -57.678 -21.778 0.25 22.31  ? 763  SER   A N   1 
ATOM   3666 N  N   B SER   A 1 500 ? -21.325 -57.668 -21.799 0.25 23.47  ? 763  SER   A N   1 
ATOM   3667 C  CA  A SER   A 1 500 ? -21.766 -58.542 -22.899 0.25 22.17  ? 763  SER   A CA  1 
ATOM   3668 C  CA  B SER   A 1 500 ? -21.743 -58.558 -22.914 0.25 24.07  ? 763  SER   A CA  1 
ATOM   3669 C  C   A SER   A 1 500 ? -21.569 -57.814 -24.234 0.25 21.58  ? 763  SER   A C   1 
ATOM   3670 C  C   B SER   A 1 500 ? -21.627 -57.825 -24.255 0.25 22.64  ? 763  SER   A C   1 
ATOM   3671 O  O   A SER   A 1 500 ? -21.117 -58.458 -25.193 0.25 22.64  ? 763  SER   A O   1 
ATOM   3672 O  O   B SER   A 1 500 ? -21.335 -58.493 -25.256 0.25 23.86  ? 763  SER   A O   1 
ATOM   3673 C  CB  A SER   A 1 500 ? -23.189 -59.009 -22.713 0.25 22.37  ? 763  SER   A CB  1 
ATOM   3674 C  CB  B SER   A 1 500 ? -23.132 -59.125 -22.720 0.25 25.51  ? 763  SER   A CB  1 
ATOM   3675 O  OG  A SER   A 1 500 ? -23.325 -59.724 -21.490 0.25 21.89  ? 763  SER   A OG  1 
ATOM   3676 O  OG  B SER   A 1 500 ? -24.127 -58.142 -22.950 0.25 28.14  ? 763  SER   A OG  1 
ATOM   3677 N  N   . LEU   A 1 501 ? -21.840 -56.509 -24.281 1.00 23.03  ? 764  LEU   A N   1 
ATOM   3678 C  CA  . LEU   A 1 501 ? -21.727 -55.724 -25.542 1.00 24.24  ? 764  LEU   A CA  1 
ATOM   3679 C  C   . LEU   A 1 501 ? -20.303 -55.247 -25.881 1.00 25.44  ? 764  LEU   A C   1 
ATOM   3680 O  O   . LEU   A 1 501 ? -19.938 -55.259 -27.073 1.00 25.60  ? 764  LEU   A O   1 
ATOM   3681 C  CB  . LEU   A 1 501 ? -22.713 -54.565 -25.452 1.00 28.36  ? 764  LEU   A CB  1 
ATOM   3682 C  CG  . LEU   A 1 501 ? -23.070 -53.957 -26.790 1.00 37.14  ? 764  LEU   A CG  1 
ATOM   3683 C  CD1 . LEU   A 1 501 ? -23.625 -55.015 -27.745 1.00 42.54  ? 764  LEU   A CD1 1 
ATOM   3684 C  CD2 . LEU   A 1 501 ? -24.094 -52.841 -26.563 1.00 43.89  ? 764  LEU   A CD2 1 
ATOM   3685 N  N   . MET   A 1 502 ? -19.515 -54.772 -24.921 1.00 23.12  ? 765  MET   A N   1 
ATOM   3686 C  CA  . MET   A 1 502 ? -18.221 -54.118 -25.165 1.00 22.52  ? 765  MET   A CA  1 
ATOM   3687 C  C   . MET   A 1 502 ? -17.050 -55.089 -24.878 1.00 23.86  ? 765  MET   A C   1 
ATOM   3688 O  O   . MET   A 1 502 ? -16.056 -54.948 -25.545 1.00 21.10  ? 765  MET   A O   1 
ATOM   3689 C  CB  . MET   A 1 502 ? -18.090 -52.893 -24.263 1.00 25.17  ? 765  MET   A CB  1 
ATOM   3690 C  CG  . MET   A 1 502 ? -19.184 -51.858 -24.481 1.00 27.18  ? 765  MET   A CG  1 
ATOM   3691 S  SD  . MET   A 1 502 ? -19.086 -51.230 -26.200 1.00 34.22  ? 765  MET   A SD  1 
ATOM   3692 C  CE  . MET   A 1 502 ? -20.425 -52.052 -27.012 1.00 39.80  ? 765  MET   A CE  1 
ATOM   3693 N  N   . TYR   A 1 503 ? -17.177 -55.992 -23.901 1.00 20.29  ? 766  TYR   A N   1 
ATOM   3694 C  CA  . TYR   A 1 503 ? -16.037 -56.770 -23.344 1.00 21.29  ? 766  TYR   A CA  1 
ATOM   3695 C  C   . TYR   A 1 503 ? -16.325 -58.277 -23.397 1.00 22.03  ? 766  TYR   A C   1 
ATOM   3696 O  O   . TYR   A 1 503 ? -15.713 -59.047 -22.600 1.00 21.65  ? 766  TYR   A O   1 
ATOM   3697 C  CB  . TYR   A 1 503 ? -15.727 -56.302 -21.924 1.00 23.08  ? 766  TYR   A CB  1 
ATOM   3698 C  CG  . TYR   A 1 503 ? -15.546 -54.811 -21.720 1.00 23.59  ? 766  TYR   A CG  1 
ATOM   3699 C  CD1 . TYR   A 1 503 ? -14.566 -54.089 -22.387 1.00 24.07  ? 766  TYR   A CD1 1 
ATOM   3700 C  CD2 . TYR   A 1 503 ? -16.352 -54.100 -20.864 1.00 26.79  ? 766  TYR   A CD2 1 
ATOM   3701 C  CE1 . TYR   A 1 503 ? -14.418 -52.725 -22.192 1.00 23.05  ? 766  TYR   A CE1 1 
ATOM   3702 C  CE2 . TYR   A 1 503 ? -16.271 -52.712 -20.714 1.00 24.73  ? 766  TYR   A CE2 1 
ATOM   3703 C  CZ  . TYR   A 1 503 ? -15.260 -52.019 -21.347 1.00 25.02  ? 766  TYR   A CZ  1 
ATOM   3704 O  OH  . TYR   A 1 503 ? -15.094 -50.665 -21.126 1.00 24.07  ? 766  TYR   A OH  1 
ATOM   3705 N  N   . PHE   A 1 504 ? -17.156 -58.708 -24.363 1.00 21.90  ? 767  PHE   A N   1 
ATOM   3706 C  CA  . PHE   A 1 504 ? -17.543 -60.124 -24.595 1.00 22.77  ? 767  PHE   A CA  1 
ATOM   3707 C  C   . PHE   A 1 504 ? -16.299 -60.983 -24.852 1.00 23.13  ? 767  PHE   A C   1 
ATOM   3708 O  O   . PHE   A 1 504 ? -16.359 -62.211 -24.678 1.00 21.67  ? 767  PHE   A O   1 
ATOM   3709 C  CB  . PHE   A 1 504 ? -18.478 -60.253 -25.809 1.00 22.17  ? 767  PHE   A CB  1 
ATOM   3710 C  CG  . PHE   A 1 504 ? -18.008 -59.503 -27.022 1.00 21.87  ? 767  PHE   A CG  1 
ATOM   3711 C  CD1 . PHE   A 1 504 ? -17.191 -60.134 -27.937 1.00 22.89  ? 767  PHE   A CD1 1 
ATOM   3712 C  CD2 . PHE   A 1 504 ? -18.329 -58.174 -27.222 1.00 22.92  ? 767  PHE   A CD2 1 
ATOM   3713 C  CE1 . PHE   A 1 504 ? -16.682 -59.458 -29.011 1.00 22.19  ? 767  PHE   A CE1 1 
ATOM   3714 C  CE2 . PHE   A 1 504 ? -17.851 -57.510 -28.336 1.00 21.36  ? 767  PHE   A CE2 1 
ATOM   3715 C  CZ  . PHE   A 1 504 ? -17.057 -58.165 -29.228 1.00 22.98  ? 767  PHE   A CZ  1 
ATOM   3716 N  N   . HIS   A 1 505 ? -15.238 -60.342 -25.366 1.00 23.53  ? 768  HIS   A N   1 
ATOM   3717 C  CA  . HIS   A 1 505 ? -13.951 -60.979 -25.760 1.00 21.56  ? 768  HIS   A CA  1 
ATOM   3718 C  C   . HIS   A 1 505 ? -13.071 -61.345 -24.556 1.00 19.31  ? 768  HIS   A C   1 
ATOM   3719 O  O   . HIS   A 1 505 ? -12.007 -61.971 -24.736 1.00 20.66  ? 768  HIS   A O   1 
ATOM   3720 C  CB  . HIS   A 1 505 ? -13.271 -60.085 -26.780 1.00 22.31  ? 768  HIS   A CB  1 
ATOM   3721 C  CG  . HIS   A 1 505 ? -13.092 -58.670 -26.337 1.00 21.99  ? 768  HIS   A CG  1 
ATOM   3722 N  ND1 . HIS   A 1 505 ? -12.025 -58.271 -25.581 1.00 20.09  ? 768  HIS   A ND1 1 
ATOM   3723 C  CD2 . HIS   A 1 505 ? -13.901 -57.597 -26.496 1.00 23.05  ? 768  HIS   A CD2 1 
ATOM   3724 C  CE1 . HIS   A 1 505 ? -12.159 -56.999 -25.321 1.00 21.95  ? 768  HIS   A CE1 1 
ATOM   3725 N  NE2 . HIS   A 1 505 ? -13.310 -56.535 -25.873 1.00 23.39  ? 768  HIS   A NE2 1 
ATOM   3726 N  N   . ARG   A 1 506 ? -13.461 -60.954 -23.342 1.00 18.18  ? 769  ARG   A N   1 
ATOM   3727 C  CA  . ARG   A 1 506 ? -12.714 -61.255 -22.081 1.00 19.32  ? 769  ARG   A CA  1 
ATOM   3728 C  C   . ARG   A 1 506 ? -13.454 -62.425 -21.428 1.00 19.97  ? 769  ARG   A C   1 
ATOM   3729 O  O   . ARG   A 1 506 ? -14.670 -62.232 -21.120 1.00 22.29  ? 769  ARG   A O   1 
ATOM   3730 C  CB  . ARG   A 1 506 ? -12.754 -60.032 -21.158 1.00 17.05  ? 769  ARG   A CB  1 
ATOM   3731 C  CG  . ARG   A 1 506 ? -12.262 -58.754 -21.821 1.00 20.48  ? 769  ARG   A CG  1 
ATOM   3732 C  CD  . ARG   A 1 506 ? -10.880 -58.871 -22.511 1.00 19.21  ? 769  ARG   A CD  1 
ATOM   3733 N  NE  . ARG   A 1 506 ? -9.904  -59.366 -21.543 1.00 20.41  ? 769  ARG   A NE  1 
ATOM   3734 C  CZ  . ARG   A 1 506 ? -9.391  -58.719 -20.513 1.00 22.16  ? 769  ARG   A CZ  1 
ATOM   3735 N  NH1 . ARG   A 1 506 ? -8.645  -59.379 -19.623 1.00 21.17  ? 769  ARG   A NH1 1 
ATOM   3736 N  NH2 . ARG   A 1 506 ? -9.545  -57.417 -20.367 1.00 21.90  ? 769  ARG   A NH2 1 
ATOM   3737 N  N   . ARG   A 1 507 ? -12.814 -63.600 -21.356 1.00 20.27  ? 770  ARG   A N   1 
ATOM   3738 C  CA  . ARG   A 1 507 ? -13.451 -64.827 -20.828 1.00 22.02  ? 770  ARG   A CA  1 
ATOM   3739 C  C   . ARG   A 1 507 ? -14.161 -64.583 -19.498 1.00 19.41  ? 770  ARG   A C   1 
ATOM   3740 O  O   . ARG   A 1 507 ? -15.328 -64.968 -19.413 1.00 21.40  ? 770  ARG   A O   1 
ATOM   3741 C  CB  . ARG   A 1 507 ? -12.445 -65.966 -20.694 1.00 23.37  ? 770  ARG   A CB  1 
ATOM   3742 C  CG  . ARG   A 1 507 ? -11.925 -66.475 -22.030 1.00 24.89  ? 770  ARG   A CG  1 
ATOM   3743 C  CD  . ARG   A 1 507 ? -10.647 -67.325 -21.867 1.00 25.77  ? 770  ARG   A CD  1 
ATOM   3744 N  NE  . ARG   A 1 507 ? -10.301 -67.867 -23.184 1.00 26.65  ? 770  ARG   A NE  1 
ATOM   3745 C  CZ  . ARG   A 1 507 ? -9.722  -67.162 -24.132 1.00 27.74  ? 770  ARG   A CZ  1 
ATOM   3746 N  NH1 . ARG   A 1 507 ? -9.358  -65.903 -23.916 1.00 24.40  ? 770  ARG   A NH1 1 
ATOM   3747 N  NH2 . ARG   A 1 507 ? -9.508  -67.704 -25.317 1.00 26.65  ? 770  ARG   A NH2 1 
ATOM   3748 N  N   . ASP   A 1 508 ? -13.521 -63.961 -18.515 1.00 18.77  ? 771  ASP   A N   1 
ATOM   3749 C  CA  . ASP   A 1 508 ? -14.085 -63.798 -17.169 1.00 20.79  ? 771  ASP   A CA  1 
ATOM   3750 C  C   . ASP   A 1 508 ? -15.334 -62.892 -17.224 1.00 23.47  ? 771  ASP   A C   1 
ATOM   3751 O  O   . ASP   A 1 508 ? -16.253 -63.118 -16.445 1.00 20.54  ? 771  ASP   A O   1 
ATOM   3752 C  CB  . ASP   A 1 508 ? -13.052 -63.201 -16.230 1.00 20.38  ? 771  ASP   A CB  1 
ATOM   3753 C  CG  . ASP   A 1 508 ? -11.831 -64.080 -16.010 1.00 21.28  ? 771  ASP   A CG  1 
ATOM   3754 O  OD1 . ASP   A 1 508 ? -11.860 -65.254 -16.447 1.00 22.67  ? 771  ASP   A OD1 1 
ATOM   3755 O  OD2 . ASP   A 1 508 ? -10.847 -63.564 -15.487 1.00 19.35  ? 771  ASP   A OD2 1 
ATOM   3756 N  N   . LEU   A 1 509 ? -15.319 -61.854 -18.071 1.00 22.90  ? 772  LEU   A N   1 
ATOM   3757 C  CA  . LEU   A 1 509 ? -16.421 -60.870 -18.065 1.00 21.08  ? 772  LEU   A CA  1 
ATOM   3758 C  C   . LEU   A 1 509 ? -17.617 -61.492 -18.783 1.00 21.30  ? 772  LEU   A C   1 
ATOM   3759 O  O   . LEU   A 1 509 ? -18.740 -61.174 -18.390 1.00 21.43  ? 772  LEU   A O   1 
ATOM   3760 C  CB  . LEU   A 1 509 ? -15.989 -59.537 -18.680 1.00 21.55  ? 772  LEU   A CB  1 
ATOM   3761 C  CG  . LEU   A 1 509 ? -14.834 -58.834 -17.943 1.00 21.62  ? 772  LEU   A CG  1 
ATOM   3762 C  CD1 . LEU   A 1 509 ? -14.564 -57.444 -18.526 1.00 22.57  ? 772  LEU   A CD1 1 
ATOM   3763 C  CD2 . LEU   A 1 509 ? -15.137 -58.720 -16.438 1.00 24.23  ? 772  LEU   A CD2 1 
ATOM   3764 N  N   . ARG   A 1 510 ? -17.425 -62.274 -19.840 1.00 20.17  ? 773  ARG   A N   1 
ATOM   3765 C  CA  . ARG   A 1 510 ? -18.605 -62.875 -20.505 1.00 24.48  ? 773  ARG   A CA  1 
ATOM   3766 C  C   . ARG   A 1 510 ? -19.267 -63.807 -19.496 1.00 25.05  ? 773  ARG   A C   1 
ATOM   3767 O  O   . ARG   A 1 510 ? -20.518 -63.851 -19.430 1.00 24.59  ? 773  ARG   A O   1 
ATOM   3768 C  CB  . ARG   A 1 510 ? -18.246 -63.572 -21.805 1.00 22.78  ? 773  ARG   A CB  1 
ATOM   3769 C  CG  . ARG   A 1 510 ? -19.479 -63.903 -22.644 1.00 25.71  ? 773  ARG   A CG  1 
ATOM   3770 C  CD  . ARG   A 1 510 ? -19.253 -64.782 -23.847 1.00 24.81  ? 773  ARG   A CD  1 
ATOM   3771 N  NE  . ARG   A 1 510 ? -18.300 -64.232 -24.781 1.00 23.74  ? 773  ARG   A NE  1 
ATOM   3772 C  CZ  . ARG   A 1 510 ? -18.131 -64.694 -26.009 1.00 23.82  ? 773  ARG   A CZ  1 
ATOM   3773 N  NH1 . ARG   A 1 510 ? -18.905 -65.669 -26.479 1.00 26.85  ? 773  ARG   A NH1 1 
ATOM   3774 N  NH2 . ARG   A 1 510 ? -17.245 -64.143 -26.809 1.00 25.94  ? 773  ARG   A NH2 1 
ATOM   3775 N  N   . LEU   A 1 511 ? -18.461 -64.594 -18.760 1.00 23.84  ? 774  LEU   A N   1 
ATOM   3776 C  CA  . LEU   A 1 511 ? -18.992 -65.553 -17.770 1.00 24.67  ? 774  LEU   A CA  1 
ATOM   3777 C  C   . LEU   A 1 511 ? -19.702 -64.776 -16.647 1.00 23.75  ? 774  LEU   A C   1 
ATOM   3778 O  O   . LEU   A 1 511 ? -20.838 -65.115 -16.290 1.00 21.80  ? 774  LEU   A O   1 
ATOM   3779 C  CB  . LEU   A 1 511 ? -17.845 -66.417 -17.220 1.00 24.53  ? 774  LEU   A CB  1 
ATOM   3780 C  CG  . LEU   A 1 511 ? -18.270 -67.716 -16.526 1.00 27.99  ? 774  LEU   A CG  1 
ATOM   3781 C  CD1 . LEU   A 1 511 ? -17.092 -68.659 -16.411 1.00 28.89  ? 774  LEU   A CD1 1 
ATOM   3782 C  CD2 . LEU   A 1 511 ? -18.848 -67.498 -15.143 1.00 27.22  ? 774  LEU   A CD2 1 
ATOM   3783 N  N   . ALA   A 1 512 ? -19.074 -63.776 -16.072 1.00 22.84  ? 775  ALA   A N   1 
ATOM   3784 C  CA  . ALA   A 1 512 ? -19.662 -63.025 -14.929 1.00 21.47  ? 775  ALA   A CA  1 
ATOM   3785 C  C   . ALA   A 1 512 ? -20.931 -62.274 -15.401 1.00 22.56  ? 775  ALA   A C   1 
ATOM   3786 O  O   . ALA   A 1 512 ? -21.889 -62.210 -14.637 1.00 21.84  ? 775  ALA   A O   1 
ATOM   3787 C  CB  . ALA   A 1 512 ? -18.656 -62.086 -14.348 1.00 19.71  ? 775  ALA   A CB  1 
ATOM   3788 N  N   . ALA   A 1 513 ? -20.949 -61.766 -16.630 1.00 21.28  ? 776  ALA   A N   1 
ATOM   3789 C  CA  . ALA   A 1 513 ? -22.131 -61.067 -17.199 1.00 21.79  ? 776  ALA   A CA  1 
ATOM   3790 C  C   . ALA   A 1 513 ? -23.296 -62.051 -17.322 1.00 22.38  ? 776  ALA   A C   1 
ATOM   3791 O  O   . ALA   A 1 513 ? -24.406 -61.727 -16.872 1.00 22.49  ? 776  ALA   A O   1 
ATOM   3792 C  CB  . ALA   A 1 513 ? -21.833 -60.447 -18.552 1.00 21.66  ? 776  ALA   A CB  1 
ATOM   3793 N  N   . ASN   A 1 514 ? -23.021 -63.209 -17.882 1.00 21.35  ? 777  ASN   A N   1 
ATOM   3794 C  CA  . ASN   A 1 514 ? -24.046 -64.302 -17.946 1.00 24.01  ? 777  ASN   A CA  1 
ATOM   3795 C  C   . ASN   A 1 514 ? -24.563 -64.649 -16.547 1.00 22.79  ? 777  ASN   A C   1 
ATOM   3796 O  O   . ASN   A 1 514 ? -25.837 -64.770 -16.378 1.00 22.42  ? 777  ASN   A O   1 
ATOM   3797 C  CB  . ASN   A 1 514 ? -23.503 -65.501 -18.675 1.00 25.75  ? 777  ASN   A CB  1 
ATOM   3798 C  CG  . ASN   A 1 514 ? -23.489 -65.233 -20.168 1.00 30.16  ? 777  ASN   A CG  1 
ATOM   3799 O  OD1 . ASN   A 1 514 ? -24.341 -64.528 -20.683 1.00 33.95  ? 777  ASN   A OD1 1 
ATOM   3800 N  ND2 . ASN   A 1 514 ? -22.566 -65.854 -20.866 1.00 32.46  ? 777  ASN   A ND2 1 
ATOM   3801 N  N   . ALA   A 1 515 ? -23.677 -64.775 -15.553 1.00 23.42  ? 778  ALA   A N   1 
ATOM   3802 C  CA  . ALA   A 1 515 ? -24.084 -65.113 -14.170 1.00 22.38  ? 778  ALA   A CA  1 
ATOM   3803 C  C   . ALA   A 1 515 ? -24.997 -64.015 -13.616 1.00 22.76  ? 778  ALA   A C   1 
ATOM   3804 O  O   . ALA   A 1 515 ? -26.049 -64.338 -13.007 1.00 23.69  ? 778  ALA   A O   1 
ATOM   3805 C  CB  . ALA   A 1 515 ? -22.917 -65.353 -13.258 1.00 21.95  ? 778  ALA   A CB  1 
ATOM   3806 N  N   . ILE   A 1 516 ? -24.591 -62.747 -13.699 1.00 22.28  ? 779  ILE   A N   1 
ATOM   3807 C  CA  . ILE   A 1 516 ? -25.395 -61.638 -13.134 1.00 23.21  ? 779  ILE   A CA  1 
ATOM   3808 C  C   . ILE   A 1 516 ? -26.763 -61.614 -13.851 1.00 25.89  ? 779  ILE   A C   1 
ATOM   3809 O  O   . ILE   A 1 516 ? -27.786 -61.506 -13.168 1.00 23.72  ? 779  ILE   A O   1 
ATOM   3810 C  CB  . ILE   A 1 516 ? -24.656 -60.294 -13.293 1.00 22.40  ? 779  ILE   A CB  1 
ATOM   3811 C  CG1 . ILE   A 1 516 ? -23.398 -60.246 -12.430 1.00 22.88  ? 779  ILE   A CG1 1 
ATOM   3812 C  CG2 . ILE   A 1 516 ? -25.581 -59.140 -12.995 1.00 21.04  ? 779  ILE   A CG2 1 
ATOM   3813 C  CD1 . ILE   A 1 516 ? -22.407 -59.194 -12.922 1.00 24.30  ? 779  ILE   A CD1 1 
ATOM   3814 N  N   . CYS   A 1 517 ? -26.812 -61.731 -15.181 1.00 24.05  ? 780  CYS   A N   1 
ATOM   3815 C  CA  . CYS   A 1 517 ? -28.101 -61.712 -15.923 1.00 24.00  ? 780  CYS   A CA  1 
ATOM   3816 C  C   . CYS   A 1 517 ? -28.943 -62.936 -15.511 1.00 25.78  ? 780  CYS   A C   1 
ATOM   3817 O  O   . CYS   A 1 517 ? -30.183 -62.833 -15.555 1.00 27.18  ? 780  CYS   A O   1 
ATOM   3818 C  CB  . CYS   A 1 517 ? -27.870 -61.612 -17.431 1.00 26.14  ? 780  CYS   A CB  1 
ATOM   3819 S  SG  . CYS   A 1 517 ? -27.239 -59.976 -17.888 1.00 29.36  ? 780  CYS   A SG  1 
ATOM   3820 N  N   . SER   A 1 518 ? -28.326 -64.038 -15.073 1.00 24.06  ? 781  SER   A N   1 
ATOM   3821 C  CA  . SER   A 1 518 ? -29.094 -65.248 -14.674 1.00 25.47  ? 781  SER   A CA  1 
ATOM   3822 C  C   . SER   A 1 518 ? -29.626 -65.012 -13.260 1.00 27.25  ? 781  SER   A C   1 
ATOM   3823 O  O   . SER   A 1 518 ? -30.633 -65.637 -12.896 1.00 27.72  ? 781  SER   A O   1 
ATOM   3824 C  CB  . SER   A 1 518 ? -28.298 -66.533 -14.751 1.00 27.04  ? 781  SER   A CB  1 
ATOM   3825 O  OG  . SER   A 1 518 ? -27.764 -66.747 -16.042 1.00 28.19  ? 781  SER   A OG  1 
ATOM   3826 N  N   . ALA   A 1 519 ? -28.950 -64.168 -12.476 1.00 22.91  ? 782  ALA   A N   1 
ATOM   3827 C  CA  . ALA   A 1 519 ? -29.225 -64.008 -11.030 1.00 23.61  ? 782  ALA   A CA  1 
ATOM   3828 C  C   . ALA   A 1 519 ? -30.251 -62.896 -10.830 1.00 22.87  ? 782  ALA   A C   1 
ATOM   3829 O  O   . ALA   A 1 519 ? -30.772 -62.820 -9.725  1.00 25.84  ? 782  ALA   A O   1 
ATOM   3830 C  CB  . ALA   A 1 519 ? -27.989 -63.765 -10.205 1.00 24.95  ? 782  ALA   A CB  1 
ATOM   3831 N  N   . VAL   A 1 520 ? -30.437 -62.007 -11.798 1.00 25.34  ? 783  VAL   A N   1 
ATOM   3832 C  CA  . VAL   A 1 520 ? -31.376 -60.860 -11.669 1.00 26.31  ? 783  VAL   A CA  1 
ATOM   3833 C  C   . VAL   A 1 520 ? -32.654 -61.242 -12.421 1.00 26.06  ? 783  VAL   A C   1 
ATOM   3834 O  O   . VAL   A 1 520 ? -32.578 -61.756 -13.536 1.00 24.90  ? 783  VAL   A O   1 
ATOM   3835 C  CB  . VAL   A 1 520 ? -30.743 -59.557 -12.198 1.00 28.30  ? 783  VAL   A CB  1 
ATOM   3836 C  CG1 . VAL   A 1 520 ? -31.739 -58.404 -12.181 1.00 27.49  ? 783  VAL   A CG1 1 
ATOM   3837 C  CG2 . VAL   A 1 520 ? -29.481 -59.189 -11.399 1.00 26.67  ? 783  VAL   A CG2 1 
ATOM   3838 N  N   . PRO   A 1 521 ? -33.877 -60.964 -11.891 1.00 26.79  ? 784  PRO   A N   1 
ATOM   3839 C  CA  . PRO   A 1 521 ? -35.096 -61.311 -12.635 1.00 28.39  ? 784  PRO   A CA  1 
ATOM   3840 C  C   . PRO   A 1 521 ? -35.029 -60.797 -14.085 1.00 27.51  ? 784  PRO   A C   1 
ATOM   3841 O  O   . PRO   A 1 521 ? -34.681 -59.651 -14.323 1.00 28.03  ? 784  PRO   A O   1 
ATOM   3842 C  CB  . PRO   A 1 521 ? -36.213 -60.687 -11.755 1.00 24.82  ? 784  PRO   A CB  1 
ATOM   3843 C  CG  . PRO   A 1 521 ? -35.645 -60.769 -10.332 1.00 28.02  ? 784  PRO   A CG  1 
ATOM   3844 C  CD  . PRO   A 1 521 ? -34.160 -60.456 -10.535 1.00 25.95  ? 784  PRO   A CD  1 
ATOM   3845 N  N   A SER   A 1 522 ? -35.385 -61.655 -15.040 0.25 30.02  ? 785  SER   A N   1 
ATOM   3846 N  N   B SER   A 1 522 ? -35.407 -61.667 -15.024 0.25 29.50  ? 785  SER   A N   1 
ATOM   3847 C  CA  A SER   A 1 522 ? -35.245 -61.411 -16.500 0.25 31.99  ? 785  SER   A CA  1 
ATOM   3848 C  CA  B SER   A 1 522 ? -35.321 -61.471 -16.496 0.25 31.11  ? 785  SER   A CA  1 
ATOM   3849 C  C   A SER   A 1 522 ? -35.909 -60.094 -16.920 0.25 33.08  ? 785  SER   A C   1 
ATOM   3850 C  C   B SER   A 1 522 ? -35.921 -60.126 -16.919 0.25 32.51  ? 785  SER   A C   1 
ATOM   3851 O  O   A SER   A 1 522 ? -35.330 -59.404 -17.785 0.25 29.49  ? 785  SER   A O   1 
ATOM   3852 O  O   B SER   A 1 522 ? -35.309 -59.456 -17.775 0.25 29.19  ? 785  SER   A O   1 
ATOM   3853 C  CB  A SER   A 1 522 ? -35.800 -62.562 -17.283 0.25 35.52  ? 785  SER   A CB  1 
ATOM   3854 C  CB  B SER   A 1 522 ? -35.994 -62.611 -17.221 0.25 33.85  ? 785  SER   A CB  1 
ATOM   3855 O  OG  A SER   A 1 522 ? -37.203 -62.633 -17.108 0.25 38.84  ? 785  SER   A OG  1 
ATOM   3856 O  OG  B SER   A 1 522 ? -35.868 -63.821 -16.488 0.25 35.35  ? 785  SER   A OG  1 
ATOM   3857 N  N   . HIS   A 1 523 ? -37.072 -59.743 -16.345 1.00 32.51  ? 786  HIS   A N   1 
ATOM   3858 C  CA  . HIS   A 1 523 ? -37.835 -58.527 -16.774 1.00 29.35  ? 786  HIS   A CA  1 
ATOM   3859 C  C   . HIS   A 1 523 ? -37.436 -57.251 -16.035 1.00 29.83  ? 786  HIS   A C   1 
ATOM   3860 O  O   . HIS   A 1 523 ? -37.863 -56.146 -16.467 1.00 31.05  ? 786  HIS   A O   1 
ATOM   3861 C  CB  . HIS   A 1 523 ? -39.361 -58.790 -16.727 1.00 33.95  ? 786  HIS   A CB  1 
ATOM   3862 C  CG  . HIS   A 1 523 ? -39.784 -59.890 -17.643 1.00 32.18  ? 786  HIS   A CG  1 
ATOM   3863 N  ND1 . HIS   A 1 523 ? -39.931 -59.684 -19.014 1.00 39.08  ? 786  HIS   A ND1 1 
ATOM   3864 C  CD2 . HIS   A 1 523 ? -39.998 -61.207 -17.435 1.00 40.76  ? 786  HIS   A CD2 1 
ATOM   3865 C  CE1 . HIS   A 1 523 ? -40.282 -60.828 -19.591 1.00 41.14  ? 786  HIS   A CE1 1 
ATOM   3866 N  NE2 . HIS   A 1 523 ? -40.323 -61.781 -18.652 1.00 39.70  ? 786  HIS   A NE2 1 
ATOM   3867 N  N   . TRP   A 1 524 ? -36.598 -57.320 -15.001 1.00 28.95  ? 787  TRP   A N   1 
ATOM   3868 C  CA  . TRP   A 1 524 ? -36.181 -56.088 -14.298 1.00 26.94  ? 787  TRP   A CA  1 
ATOM   3869 C  C   . TRP   A 1 524 ? -35.270 -55.263 -15.209 1.00 28.22  ? 787  TRP   A C   1 
ATOM   3870 O  O   . TRP   A 1 524 ? -34.425 -55.831 -15.914 1.00 29.31  ? 787  TRP   A O   1 
ATOM   3871 C  CB  . TRP   A 1 524 ? -35.558 -56.430 -12.928 1.00 29.49  ? 787  TRP   A CB  1 
ATOM   3872 C  CG  . TRP   A 1 524 ? -36.542 -56.882 -11.882 1.00 30.08  ? 787  TRP   A CG  1 
ATOM   3873 C  CD1 . TRP   A 1 524 ? -37.870 -57.190 -12.044 1.00 29.97  ? 787  TRP   A CD1 1 
ATOM   3874 C  CD2 . TRP   A 1 524 ? -36.246 -57.144 -10.497 1.00 28.29  ? 787  TRP   A CD2 1 
ATOM   3875 N  NE1 . TRP   A 1 524 ? -38.411 -57.627 -10.855 1.00 29.15  ? 787  TRP   A NE1 1 
ATOM   3876 C  CE2 . TRP   A 1 524 ? -37.448 -57.565 -9.879  1.00 29.38  ? 787  TRP   A CE2 1 
ATOM   3877 C  CE3 . TRP   A 1 524 ? -35.080 -57.060 -9.733  1.00 30.83  ? 787  TRP   A CE3 1 
ATOM   3878 C  CZ2 . TRP   A 1 524 ? -37.522 -57.865 -8.517  1.00 30.53  ? 787  TRP   A CZ2 1 
ATOM   3879 C  CZ3 . TRP   A 1 524 ? -35.159 -57.376 -8.387  1.00 32.49  ? 787  TRP   A CZ3 1 
ATOM   3880 C  CH2 . TRP   A 1 524 ? -36.356 -57.755 -7.791  1.00 26.79  ? 787  TRP   A CH2 1 
ATOM   3881 N  N   . VAL   A 1 525 ? -35.478 -53.958 -15.177 1.00 30.12  ? 788  VAL   A N   1 
ATOM   3882 C  CA  . VAL   A 1 525 ? -34.928 -52.998 -16.151 1.00 31.66  ? 788  VAL   A CA  1 
ATOM   3883 C  C   . VAL   A 1 525 ? -33.601 -52.475 -15.603 1.00 31.10  ? 788  VAL   A C   1 
ATOM   3884 O  O   . VAL   A 1 525 ? -33.523 -51.895 -14.523 1.00 32.68  ? 788  VAL   A O   1 
ATOM   3885 C  CB  . VAL   A 1 525 ? -35.943 -51.861 -16.360 1.00 35.93  ? 788  VAL   A CB  1 
ATOM   3886 C  CG1 . VAL   A 1 525 ? -35.388 -50.819 -17.325 1.00 38.11  ? 788  VAL   A CG1 1 
ATOM   3887 C  CG2 . VAL   A 1 525 ? -37.315 -52.387 -16.805 1.00 36.81  ? 788  VAL   A CG2 1 
ATOM   3888 N  N   . PRO   A 1 526 ? -32.508 -52.557 -16.362 1.00 34.09  ? 789  PRO   A N   1 
ATOM   3889 C  CA  . PRO   A 1 526 ? -31.244 -51.979 -15.905 1.00 30.45  ? 789  PRO   A CA  1 
ATOM   3890 C  C   . PRO   A 1 526 ? -31.359 -50.486 -15.606 1.00 33.52  ? 789  PRO   A C   1 
ATOM   3891 O  O   . PRO   A 1 526 ? -32.036 -49.780 -16.362 1.00 31.76  ? 789  PRO   A O   1 
ATOM   3892 C  CB  . PRO   A 1 526 ? -30.315 -52.121 -17.113 1.00 31.27  ? 789  PRO   A CB  1 
ATOM   3893 C  CG  . PRO   A 1 526 ? -30.960 -53.124 -18.008 1.00 30.63  ? 789  PRO   A CG  1 
ATOM   3894 C  CD  . PRO   A 1 526 ? -32.439 -53.090 -17.725 1.00 31.58  ? 789  PRO   A CD  1 
ATOM   3895 N  N   . THR   A 1 527 ? -30.683 -50.030 -14.558 1.00 35.84  ? 790  THR   A N   1 
ATOM   3896 C  CA  . THR   A 1 527 ? -30.653 -48.608 -14.147 1.00 40.73  ? 790  THR   A CA  1 
ATOM   3897 C  C   . THR   A 1 527 ? -29.234 -48.143 -13.887 1.00 46.56  ? 790  THR   A C   1 
ATOM   3898 O  O   . THR   A 1 527 ? -28.321 -48.988 -13.700 1.00 43.87  ? 790  THR   A O   1 
ATOM   3899 C  CB  . THR   A 1 527 ? -31.360 -48.316 -12.815 1.00 51.34  ? 790  THR   A CB  1 
ATOM   3900 O  OG1 . THR   A 1 527 ? -30.910 -49.236 -11.802 1.00 56.72  ? 790  THR   A OG1 1 
ATOM   3901 C  CG2 . THR   A 1 527 ? -32.856 -48.328 -12.969 1.00 52.09  ? 790  THR   A CG2 1 
ATOM   3902 N  N   . SER   A 1 528 ? -29.101 -46.829 -13.891 1.00 45.17  ? 791  SER   A N   1 
ATOM   3903 C  CA  . SER   A 1 528 ? -27.928 -46.031 -13.469 1.00 64.25  ? 791  SER   A CA  1 
ATOM   3904 C  C   . SER   A 1 528 ? -28.504 -44.787 -12.788 1.00 72.11  ? 791  SER   A C   1 
ATOM   3905 O  O   . SER   A 1 528 ? -29.664 -44.463 -13.130 1.00 73.66  ? 791  SER   A O   1 
ATOM   3906 C  CB  . SER   A 1 528 ? -27.077 -45.682 -14.655 1.00 59.51  ? 791  SER   A CB  1 
ATOM   3907 O  OG  . SER   A 1 528 ? -25.736 -45.480 -14.249 1.00 73.58  ? 791  SER   A OG  1 
ATOM   3908 N  N   . ARG   A 1 529 ? -27.769 -44.137 -11.875 1.00 87.77  ? 792  ARG   A N   1 
ATOM   3909 C  CA  . ARG   A 1 529 ? -28.190 -42.846 -11.250 1.00 89.17  ? 792  ARG   A CA  1 
ATOM   3910 C  C   . ARG   A 1 529 ? -27.550 -41.653 -11.983 1.00 92.35  ? 792  ARG   A C   1 
ATOM   3911 O  O   . ARG   A 1 529 ? -28.162 -40.578 -11.925 1.00 87.18  ? 792  ARG   A O   1 
ATOM   3912 C  CB  . ARG   A 1 529 ? -27.925 -42.833 -9.740  1.00 85.69  ? 792  ARG   A CB  1 
ATOM   3913 C  CG  . ARG   A 1 529 ? -29.110 -43.334 -8.927  1.00 81.42  ? 792  ARG   A CG  1 
ATOM   3914 C  CD  . ARG   A 1 529 ? -28.996 -43.064 -7.436  1.00 78.81  ? 792  ARG   A CD  1 
ATOM   3915 N  NE  . ARG   A 1 529 ? -29.703 -44.074 -6.655  1.00 70.37  ? 792  ARG   A NE  1 
ATOM   3916 C  CZ  . ARG   A 1 529 ? -29.694 -44.160 -5.331  1.00 63.14  ? 792  ARG   A CZ  1 
ATOM   3917 N  NH1 . ARG   A 1 529 ? -29.027 -43.274 -4.610  1.00 58.72  ? 792  ARG   A NH1 1 
ATOM   3918 N  NH2 . ARG   A 1 529 ? -30.357 -45.137 -4.735  1.00 56.67  ? 792  ARG   A NH2 1 
ATOM   3919 N  N   . THR   A 1 530 ? -26.387 -41.822 -12.634 1.00 111.05 ? 793  THR   A N   1 
ATOM   3920 C  CA  . THR   A 1 530 ? -25.872 -40.920 -13.713 1.00 130.53 ? 793  THR   A CA  1 
ATOM   3921 C  C   . THR   A 1 530 ? -25.582 -41.772 -14.957 1.00 141.88 ? 793  THR   A C   1 
ATOM   3922 O  O   . THR   A 1 530 ? -24.907 -42.812 -14.812 1.00 144.79 ? 793  THR   A O   1 
ATOM   3923 C  CB  . THR   A 1 530 ? -24.636 -40.100 -13.302 1.00 128.42 ? 793  THR   A CB  1 
ATOM   3924 O  OG1 . THR   A 1 530 ? -23.472 -40.927 -13.341 1.00 125.05 ? 793  THR   A OG1 1 
ATOM   3925 C  CG2 . THR   A 1 530 ? -24.757 -39.458 -11.936 1.00 124.98 ? 793  THR   A CG2 1 
ATOM   3926 N  N   . THR   A 1 531 ? -26.070 -41.345 -16.127 1.00 156.35 ? 794  THR   A N   1 
ATOM   3927 C  CA  . THR   A 1 531 ? -26.051 -42.127 -17.396 1.00 161.68 ? 794  THR   A CA  1 
ATOM   3928 C  C   . THR   A 1 531 ? -24.830 -41.721 -18.236 1.00 156.64 ? 794  THR   A C   1 
ATOM   3929 O  O   . THR   A 1 531 ? -23.745 -42.295 -17.990 1.00 146.95 ? 794  THR   A O   1 
ATOM   3930 C  CB  . THR   A 1 531 ? -27.378 -41.963 -18.153 1.00 161.63 ? 794  THR   A CB  1 
ATOM   3931 O  OG1 . THR   A 1 531 ? -27.415 -40.673 -18.762 1.00 169.37 ? 794  THR   A OG1 1 
ATOM   3932 C  CG2 . THR   A 1 531 ? -28.590 -42.126 -17.259 1.00 156.91 ? 794  THR   A CG2 1 
ATOM   3933 N  N   . ALA   A 1 536 ? -20.720 -40.758 -24.869 1.00 99.28  ? 799  ALA   A N   1 
ATOM   3934 C  CA  . ALA   A 1 536 ? -20.897 -42.135 -25.393 1.00 95.02  ? 799  ALA   A CA  1 
ATOM   3935 C  C   . ALA   A 1 536 ? -22.388 -42.422 -25.664 1.00 86.66  ? 799  ALA   A C   1 
ATOM   3936 O  O   . ALA   A 1 536 ? -23.242 -41.529 -25.451 1.00 95.04  ? 799  ALA   A O   1 
ATOM   3937 C  CB  . ALA   A 1 536 ? -20.288 -43.126 -24.419 1.00 96.74  ? 799  ALA   A CB  1 
ATOM   3938 N  N   . THR   A 1 537 ? -22.677 -43.637 -26.140 0.50 83.27  ? 800  THR   A N   1 
ATOM   3939 C  CA  . THR   A 1 537 ? -24.040 -44.165 -26.423 0.50 74.88  ? 800  THR   A CA  1 
ATOM   3940 C  C   . THR   A 1 537 ? -24.225 -45.462 -25.627 0.50 68.30  ? 800  THR   A C   1 
ATOM   3941 O  O   . THR   A 1 537 ? -23.340 -46.339 -25.731 0.50 72.31  ? 800  THR   A O   1 
ATOM   3942 C  CB  . THR   A 1 537 ? -24.233 -44.378 -27.929 0.50 77.96  ? 800  THR   A CB  1 
ATOM   3943 O  OG1 . THR   A 1 537 ? -23.666 -45.640 -28.283 0.50 80.29  ? 800  THR   A OG1 1 
ATOM   3944 C  CG2 . THR   A 1 537 ? -23.598 -43.286 -28.761 0.50 76.33  ? 800  THR   A CG2 1 
ATOM   3945 N  N   A HIS   A 1 538 ? -25.310 -45.581 -24.857 0.25 54.84  ? 801  HIS   A N   1 
ATOM   3946 N  N   B HIS   A 1 538 ? -25.363 -45.561 -24.910 0.25 58.75  ? 801  HIS   A N   1 
ATOM   3947 C  CA  A HIS   A 1 538 ? -25.501 -46.678 -23.870 0.25 46.65  ? 801  HIS   A CA  1 
ATOM   3948 C  CA  B HIS   A 1 538 ? -25.640 -46.601 -23.883 0.25 51.36  ? 801  HIS   A CA  1 
ATOM   3949 C  C   A HIS   A 1 538 ? -26.489 -47.721 -24.416 0.25 40.92  ? 801  HIS   A C   1 
ATOM   3950 C  C   B HIS   A 1 538 ? -26.542 -47.709 -24.447 0.25 43.34  ? 801  HIS   A C   1 
ATOM   3951 O  O   A HIS   A 1 538 ? -27.597 -47.861 -23.858 0.25 38.43  ? 801  HIS   A O   1 
ATOM   3952 O  O   B HIS   A 1 538 ? -27.665 -47.883 -23.926 0.25 40.31  ? 801  HIS   A O   1 
ATOM   3953 C  CB  A HIS   A 1 538 ? -25.877 -46.078 -22.512 0.25 46.26  ? 801  HIS   A CB  1 
ATOM   3954 C  CB  B HIS   A 1 538 ? -26.252 -45.941 -22.640 0.25 54.51  ? 801  HIS   A CB  1 
ATOM   3955 C  CG  A HIS   A 1 538 ? -24.749 -45.345 -21.865 0.25 44.83  ? 801  HIS   A CG  1 
ATOM   3956 C  CG  B HIS   A 1 538 ? -26.916 -44.631 -22.908 0.25 56.25  ? 801  HIS   A CG  1 
ATOM   3957 N  ND1 A HIS   A 1 538 ? -24.575 -45.314 -20.493 0.25 46.78  ? 801  HIS   A ND1 1 
ATOM   3958 N  ND1 B HIS   A 1 538 ? -26.704 -43.520 -22.112 0.25 58.38  ? 801  HIS   A ND1 1 
ATOM   3959 C  CD2 A HIS   A 1 538 ? -23.720 -44.649 -22.394 0.25 44.14  ? 801  HIS   A CD2 1 
ATOM   3960 C  CD2 B HIS   A 1 538 ? -27.770 -44.241 -23.881 0.25 59.75  ? 801  HIS   A CD2 1 
ATOM   3961 C  CE1 A HIS   A 1 538 ? -23.497 -44.610 -20.206 0.25 46.26  ? 801  HIS   A CE1 1 
ATOM   3962 C  CE1 B HIS   A 1 538 ? -27.407 -42.507 -22.578 0.25 60.04  ? 801  HIS   A CE1 1 
ATOM   3963 N  NE2 A HIS   A 1 538 ? -22.954 -44.193 -21.357 0.25 45.07  ? 801  HIS   A NE2 1 
ATOM   3964 N  NE2 B HIS   A 1 538 ? -28.074 -42.923 -23.663 0.25 57.49  ? 801  HIS   A NE2 1 
ATOM   3965 N  N   . GLU   A 1 539 ? -26.063 -48.472 -25.434 1.00 38.08  ? 802  GLU   A N   1 
ATOM   3966 C  CA  . GLU   A 1 539 ? -26.912 -49.497 -26.107 1.00 37.92  ? 802  GLU   A CA  1 
ATOM   3967 C  C   . GLU   A 1 539 ? -27.244 -50.671 -25.185 1.00 37.83  ? 802  GLU   A C   1 
ATOM   3968 O  O   . GLU   A 1 539 ? -28.206 -51.409 -25.528 1.00 34.84  ? 802  GLU   A O   1 
ATOM   3969 C  CB  . GLU   A 1 539 ? -26.269 -50.020 -27.377 1.00 46.15  ? 802  GLU   A CB  1 
ATOM   3970 C  CG  . GLU   A 1 539 ? -26.596 -49.170 -28.584 1.00 52.20  ? 802  GLU   A CG  1 
ATOM   3971 C  CD  . GLU   A 1 539 ? -25.448 -48.229 -28.841 1.00 64.13  ? 802  GLU   A CD  1 
ATOM   3972 O  OE1 . GLU   A 1 539 ? -25.404 -47.669 -29.961 1.00 76.23  ? 802  GLU   A OE1 1 
ATOM   3973 O  OE2 . GLU   A 1 539 ? -24.570 -48.110 -27.924 1.00 68.60  ? 802  GLU   A OE2 1 
ATOM   3974 N  N   . TRP   A 1 540 ? -26.483 -50.871 -24.086 1.00 27.19  ? 803  TRP   A N   1 
ATOM   3975 C  CA  . TRP   A 1 540 ? -26.769 -51.981 -23.141 1.00 30.21  ? 803  TRP   A CA  1 
ATOM   3976 C  C   . TRP   A 1 540 ? -27.927 -51.624 -22.204 1.00 31.71  ? 803  TRP   A C   1 
ATOM   3977 O  O   . TRP   A 1 540 ? -28.297 -52.432 -21.355 1.00 30.10  ? 803  TRP   A O   1 
ATOM   3978 C  CB  . TRP   A 1 540 ? -25.486 -52.314 -22.366 1.00 30.84  ? 803  TRP   A CB  1 
ATOM   3979 C  CG  . TRP   A 1 540 ? -24.914 -51.182 -21.584 1.00 23.85  ? 803  TRP   A CG  1 
ATOM   3980 C  CD1 . TRP   A 1 540 ? -25.225 -50.806 -20.317 1.00 25.88  ? 803  TRP   A CD1 1 
ATOM   3981 C  CD2 . TRP   A 1 540 ? -23.918 -50.261 -22.049 1.00 25.86  ? 803  TRP   A CD2 1 
ATOM   3982 N  NE1 . TRP   A 1 540 ? -24.495 -49.703 -19.958 1.00 29.62  ? 803  TRP   A NE1 1 
ATOM   3983 C  CE2 . TRP   A 1 540 ? -23.671 -49.358 -20.994 1.00 28.71  ? 803  TRP   A CE2 1 
ATOM   3984 C  CE3 . TRP   A 1 540 ? -23.182 -50.146 -23.232 1.00 30.09  ? 803  TRP   A CE3 1 
ATOM   3985 C  CZ2 . TRP   A 1 540 ? -22.737 -48.337 -21.107 1.00 34.53  ? 803  TRP   A CZ2 1 
ATOM   3986 C  CZ3 . TRP   A 1 540 ? -22.264 -49.127 -23.345 1.00 34.47  ? 803  TRP   A CZ3 1 
ATOM   3987 C  CH2 . TRP   A 1 540 ? -22.026 -48.255 -22.286 1.00 32.62  ? 803  TRP   A CH2 1 
ATOM   3988 N  N   . MET   A 1 541 ? -28.428 -50.389 -22.252 1.00 31.62  ? 804  MET   A N   1 
ATOM   3989 C  CA  . MET   A 1 541 ? -29.478 -49.967 -21.306 1.00 31.57  ? 804  MET   A CA  1 
ATOM   3990 C  C   . MET   A 1 541 ? -30.841 -50.266 -21.953 1.00 36.86  ? 804  MET   A C   1 
ATOM   3991 O  O   . MET   A 1 541 ? -31.422 -49.375 -22.575 1.00 36.02  ? 804  MET   A O   1 
ATOM   3992 C  CB  . MET   A 1 541 ? -29.323 -48.500 -20.912 1.00 36.07  ? 804  MET   A CB  1 
ATOM   3993 C  CG  . MET   A 1 541 ? -28.007 -48.209 -20.164 1.00 40.47  ? 804  MET   A CG  1 
ATOM   3994 S  SD  . MET   A 1 541 ? -27.926 -49.052 -18.567 1.00 38.48  ? 804  MET   A SD  1 
ATOM   3995 C  CE  . MET   A 1 541 ? -29.115 -48.150 -17.585 1.00 41.56  ? 804  MET   A CE  1 
ATOM   3996 N  N   . THR   A 1 542 ? -31.323 -51.498 -21.793 1.00 34.17  ? 805  THR   A N   1 
ATOM   3997 C  CA  . THR   A 1 542 ? -32.444 -52.070 -22.577 1.00 36.19  ? 805  THR   A CA  1 
ATOM   3998 C  C   . THR   A 1 542 ? -32.811 -53.410 -21.958 1.00 35.80  ? 805  THR   A C   1 
ATOM   3999 O  O   . THR   A 1 542 ? -31.943 -53.991 -21.271 1.00 30.10  ? 805  THR   A O   1 
ATOM   4000 C  CB  . THR   A 1 542 ? -32.050 -52.287 -24.046 1.00 41.49  ? 805  THR   A CB  1 
ATOM   4001 O  OG1 . THR   A 1 542 ? -33.124 -52.909 -24.759 1.00 39.81  ? 805  THR   A OG1 1 
ATOM   4002 C  CG2 . THR   A 1 542 ? -30.829 -53.171 -24.185 1.00 44.94  ? 805  THR   A CG2 1 
ATOM   4003 N  N   . THR   A 1 543 ? -34.039 -53.887 -22.165 1.00 32.25  ? 806  THR   A N   1 
ATOM   4004 C  CA  . THR   A 1 543 ? -34.463 -55.257 -21.784 1.00 34.23  ? 806  THR   A CA  1 
ATOM   4005 C  C   . THR   A 1 543 ? -34.527 -56.149 -23.036 1.00 35.65  ? 806  THR   A C   1 
ATOM   4006 O  O   . THR   A 1 543 ? -34.804 -57.327 -22.895 1.00 33.61  ? 806  THR   A O   1 
ATOM   4007 C  CB  . THR   A 1 543 ? -35.794 -55.174 -21.017 1.00 46.75  ? 806  THR   A CB  1 
ATOM   4008 O  OG1 . THR   A 1 543 ? -36.727 -54.521 -21.879 1.00 40.86  ? 806  THR   A OG1 1 
ATOM   4009 C  CG2 . THR   A 1 543 ? -35.667 -54.372 -19.734 1.00 47.81  ? 806  THR   A CG2 1 
ATOM   4010 N  N   . GLU   A 1 544 ? -34.226 -55.621 -24.220 1.00 34.33  ? 807  GLU   A N   1 
ATOM   4011 C  CA  . GLU   A 1 544 ? -34.034 -56.432 -25.446 1.00 33.92  ? 807  GLU   A CA  1 
ATOM   4012 C  C   . GLU   A 1 544 ? -32.947 -57.495 -25.207 1.00 37.84  ? 807  GLU   A C   1 
ATOM   4013 O  O   . GLU   A 1 544 ? -32.056 -57.288 -24.345 1.00 30.81  ? 807  GLU   A O   1 
ATOM   4014 C  CB  . GLU   A 1 544 ? -33.696 -55.493 -26.588 1.00 39.80  ? 807  GLU   A CB  1 
ATOM   4015 C  CG  . GLU   A 1 544 ? -33.573 -56.187 -27.915 1.00 46.02  ? 807  GLU   A CG  1 
ATOM   4016 C  CD  . GLU   A 1 544 ? -33.675 -55.202 -29.069 1.00 52.41  ? 807  GLU   A CD  1 
ATOM   4017 O  OE1 . GLU   A 1 544 ? -34.259 -55.585 -30.111 1.00 61.98  ? 807  GLU   A OE1 1 
ATOM   4018 O  OE2 . GLU   A 1 544 ? -33.237 -54.026 -28.892 1.00 49.92  ? 807  GLU   A OE2 1 
ATOM   4019 N  N   . ASP   A 1 545 ? -33.091 -58.628 -25.872 1.00 32.65  ? 808  ASP   A N   1 
ATOM   4020 C  CA  . ASP   A 1 545 ? -32.171 -59.789 -25.846 1.00 39.51  ? 808  ASP   A CA  1 
ATOM   4021 C  C   . ASP   A 1 545 ? -30.755 -59.319 -26.265 1.00 31.63  ? 808  ASP   A C   1 
ATOM   4022 O  O   . ASP   A 1 545 ? -30.634 -58.709 -27.338 1.00 28.93  ? 808  ASP   A O   1 
ATOM   4023 C  CB  . ASP   A 1 545 ? -32.737 -60.859 -26.770 1.00 44.67  ? 808  ASP   A CB  1 
ATOM   4024 C  CG  . ASP   A 1 545 ? -31.789 -61.991 -27.072 1.00 52.35  ? 808  ASP   A CG  1 
ATOM   4025 O  OD1 . ASP   A 1 545 ? -30.837 -61.755 -27.821 1.00 58.13  ? 808  ASP   A OD1 1 
ATOM   4026 O  OD2 . ASP   A 1 545 ? -32.038 -63.094 -26.588 1.00 63.45  ? 808  ASP   A OD2 1 
ATOM   4027 N  N   . MET   A 1 546 ? -29.715 -59.612 -25.474 1.00 30.64  ? 809  MET   A N   1 
ATOM   4028 C  CA  . MET   A 1 546 ? -28.355 -59.027 -25.724 1.00 31.24  ? 809  MET   A CA  1 
ATOM   4029 C  C   . MET   A 1 546 ? -27.757 -59.587 -27.026 1.00 27.76  ? 809  MET   A C   1 
ATOM   4030 O  O   . MET   A 1 546 ? -26.951 -58.876 -27.658 1.00 27.66  ? 809  MET   A O   1 
ATOM   4031 C  CB  . MET   A 1 546 ? -27.442 -59.231 -24.510 1.00 34.21  ? 809  MET   A CB  1 
ATOM   4032 C  CG  . MET   A 1 546 ? -27.759 -58.250 -23.371 1.00 31.22  ? 809  MET   A CG  1 
ATOM   4033 S  SD  . MET   A 1 546 ? -27.588 -56.476 -23.809 1.00 43.14  ? 809  MET   A SD  1 
ATOM   4034 C  CE  . MET   A 1 546 ? -29.241 -55.882 -24.043 1.00 50.59  ? 809  MET   A CE  1 
ATOM   4035 N  N   . LEU   A 1 547 ? -28.169 -60.762 -27.502 1.00 26.97  ? 810  LEU   A N   1 
ATOM   4036 C  CA  . LEU   A 1 547 ? -27.607 -61.263 -28.791 1.00 30.40  ? 810  LEU   A CA  1 
ATOM   4037 C  C   . LEU   A 1 547 ? -28.146 -60.382 -29.929 1.00 30.17  ? 810  LEU   A C   1 
ATOM   4038 O  O   . LEU   A 1 547 ? -27.374 -60.068 -30.883 1.00 28.88  ? 810  LEU   A O   1 
ATOM   4039 C  CB  . LEU   A 1 547 ? -27.900 -62.741 -29.046 1.00 31.15  ? 810  LEU   A CB  1 
ATOM   4040 C  CG  . LEU   A 1 547 ? -27.184 -63.352 -30.262 1.00 31.38  ? 810  LEU   A CG  1 
ATOM   4041 C  CD1 . LEU   A 1 547 ? -25.658 -63.372 -30.115 1.00 30.37  ? 810  LEU   A CD1 1 
ATOM   4042 C  CD2 . LEU   A 1 547 ? -27.676 -64.756 -30.507 1.00 33.35  ? 810  LEU   A CD2 1 
ATOM   4043 N  N   . THR   A 1 548 ? -29.415 -59.992 -29.840 1.00 27.49  ? 811  THR   A N   1 
ATOM   4044 C  CA  . THR   A 1 548 ? -30.068 -59.115 -30.843 1.00 29.39  ? 811  THR   A CA  1 
ATOM   4045 C  C   . THR   A 1 548 ? -29.361 -57.752 -30.863 1.00 27.58  ? 811  THR   A C   1 
ATOM   4046 O  O   . THR   A 1 548 ? -29.086 -57.239 -31.925 1.00 26.46  ? 811  THR   A O   1 
ATOM   4047 C  CB  . THR   A 1 548 ? -31.579 -58.967 -30.565 1.00 34.73  ? 811  THR   A CB  1 
ATOM   4048 O  OG1 . THR   A 1 548 ? -32.137 -60.284 -30.621 1.00 31.86  ? 811  THR   A OG1 1 
ATOM   4049 C  CG2 . THR   A 1 548 ? -32.238 -58.038 -31.564 1.00 34.42  ? 811  THR   A CG2 1 
ATOM   4050 N  N   . VAL   A 1 549 ? -29.079 -57.193 -29.702 1.00 28.43  ? 812  VAL   A N   1 
ATOM   4051 C  CA  . VAL   A 1 549 ? -28.359 -55.903 -29.564 1.00 28.32  ? 812  VAL   A CA  1 
ATOM   4052 C  C   . VAL   A 1 549 ? -26.926 -56.053 -30.106 1.00 26.39  ? 812  VAL   A C   1 
ATOM   4053 O  O   . VAL   A 1 549 ? -26.465 -55.125 -30.809 1.00 26.51  ? 812  VAL   A O   1 
ATOM   4054 C  CB  . VAL   A 1 549 ? -28.383 -55.364 -28.120 1.00 30.48  ? 812  VAL   A CB  1 
ATOM   4055 C  CG1 . VAL   A 1 549 ? -27.629 -54.035 -28.025 1.00 32.02  ? 812  VAL   A CG1 1 
ATOM   4056 C  CG2 . VAL   A 1 549 ? -29.807 -55.160 -27.640 1.00 35.57  ? 812  VAL   A CG2 1 
ATOM   4057 N  N   . TRP   A 1 550 ? -26.231 -57.142 -29.788 1.00 26.96  ? 813  TRP   A N   1 
ATOM   4058 C  CA  . TRP   A 1 550 ? -24.848 -57.359 -30.272 1.00 24.94  ? 813  TRP   A CA  1 
ATOM   4059 C  C   . TRP   A 1 550 ? -24.861 -57.326 -31.810 1.00 28.31  ? 813  TRP   A C   1 
ATOM   4060 O  O   . TRP   A 1 550 ? -24.010 -56.667 -32.445 1.00 26.64  ? 813  TRP   A O   1 
ATOM   4061 C  CB  . TRP   A 1 550 ? -24.290 -58.668 -29.714 1.00 25.05  ? 813  TRP   A CB  1 
ATOM   4062 C  CG  . TRP   A 1 550 ? -22.829 -58.830 -29.981 1.00 26.17  ? 813  TRP   A CG  1 
ATOM   4063 C  CD1 . TRP   A 1 550 ? -21.805 -58.608 -29.095 1.00 25.93  ? 813  TRP   A CD1 1 
ATOM   4064 C  CD2 . TRP   A 1 550 ? -22.206 -59.244 -31.200 1.00 26.16  ? 813  TRP   A CD2 1 
ATOM   4065 N  NE1 . TRP   A 1 550 ? -20.589 -58.832 -29.668 1.00 24.42  ? 813  TRP   A NE1 1 
ATOM   4066 C  CE2 . TRP   A 1 550 ? -20.803 -59.229 -30.967 1.00 26.62  ? 813  TRP   A CE2 1 
ATOM   4067 C  CE3 . TRP   A 1 550 ? -22.677 -59.691 -32.437 1.00 27.26  ? 813  TRP   A CE3 1 
ATOM   4068 C  CZ2 . TRP   A 1 550 ? -19.874 -59.600 -31.936 1.00 24.99  ? 813  TRP   A CZ2 1 
ATOM   4069 C  CZ3 . TRP   A 1 550 ? -21.753 -60.020 -33.415 1.00 24.17  ? 813  TRP   A CZ3 1 
ATOM   4070 C  CH2 . TRP   A 1 550 ? -20.373 -59.968 -33.160 1.00 23.99  ? 813  TRP   A CH2 1 
ATOM   4071 N  N   . ASN   A 1 551 ? -25.793 -58.045 -32.419 1.00 26.48  ? 814  ASN   A N   1 
ATOM   4072 C  CA  . ASN   A 1 551 ? -25.892 -58.115 -33.896 1.00 28.15  ? 814  ASN   A CA  1 
ATOM   4073 C  C   . ASN   A 1 551 ? -26.145 -56.719 -34.465 1.00 25.81  ? 814  ASN   A C   1 
ATOM   4074 O  O   . ASN   A 1 551 ? -25.553 -56.432 -35.506 1.00 28.26  ? 814  ASN   A O   1 
ATOM   4075 C  CB  . ASN   A 1 551 ? -27.002 -59.039 -34.404 1.00 31.80  ? 814  ASN   A CB  1 
ATOM   4076 C  CG  . ASN   A 1 551 ? -26.507 -60.438 -34.623 1.00 34.64  ? 814  ASN   A CG  1 
ATOM   4077 O  OD1 . ASN   A 1 551 ? -25.637 -60.677 -35.461 1.00 39.27  ? 814  ASN   A OD1 1 
ATOM   4078 N  ND2 . ASN   A 1 551 ? -27.059 -61.379 -33.879 1.00 41.01  ? 814  ASN   A ND2 1 
ATOM   4079 N  N   . ARG   A 1 552 ? -27.016 -55.927 -33.855 1.00 27.59  ? 815  ARG   A N   1 
ATOM   4080 C  CA  . ARG   A 1 552 ? -27.330 -54.581 -34.368 1.00 27.80  ? 815  ARG   A CA  1 
ATOM   4081 C  C   . ARG   A 1 552 ? -26.063 -53.715 -34.315 1.00 30.90  ? 815  ARG   A C   1 
ATOM   4082 O  O   . ARG   A 1 552 ? -25.749 -53.024 -35.288 1.00 31.68  ? 815  ARG   A O   1 
ATOM   4083 C  CB  . ARG   A 1 552 ? -28.462 -53.957 -33.569 1.00 30.07  ? 815  ARG   A CB  1 
ATOM   4084 C  CG  . ARG   A 1 552 ? -28.969 -52.652 -34.156 1.00 35.51  ? 815  ARG   A CG  1 
ATOM   4085 C  CD  . ARG   A 1 552 ? -30.036 -52.012 -33.287 1.00 42.11  ? 815  ARG   A CD  1 
ATOM   4086 N  NE  . ARG   A 1 552 ? -31.164 -52.939 -33.236 1.00 53.35  ? 815  ARG   A NE  1 
ATOM   4087 C  CZ  . ARG   A 1 552 ? -31.741 -53.436 -32.129 1.00 52.09  ? 815  ARG   A CZ  1 
ATOM   4088 N  NH1 . ARG   A 1 552 ? -31.342 -53.096 -30.915 1.00 48.14  ? 815  ARG   A NH1 1 
ATOM   4089 N  NH2 . ARG   A 1 552 ? -32.758 -54.262 -32.271 1.00 59.38  ? 815  ARG   A NH2 1 
ATOM   4090 N  N   . VAL   A 1 553 ? -25.349 -53.749 -33.193 1.00 28.21  ? 816  VAL   A N   1 
ATOM   4091 C  CA  . VAL   A 1 553 ? -24.226 -52.824 -32.940 1.00 28.54  ? 816  VAL   A CA  1 
ATOM   4092 C  C   . VAL   A 1 553 ? -23.002 -53.274 -33.764 1.00 26.09  ? 816  VAL   A C   1 
ATOM   4093 O  O   . VAL   A 1 553 ? -22.320 -52.418 -34.378 1.00 30.10  ? 816  VAL   A O   1 
ATOM   4094 C  CB  . VAL   A 1 553 ? -23.968 -52.782 -31.416 1.00 31.04  ? 816  VAL   A CB  1 
ATOM   4095 C  CG1 . VAL   A 1 553 ? -22.614 -52.236 -31.117 1.00 33.04  ? 816  VAL   A CG1 1 
ATOM   4096 C  CG2 . VAL   A 1 553 ? -25.047 -51.969 -30.726 1.00 29.08  ? 816  VAL   A CG2 1 
ATOM   4097 N  N   . TRP   A 1 554 ? -22.641 -54.555 -33.742 1.00 24.32  ? 817  TRP   A N   1 
ATOM   4098 C  CA  . TRP   A 1 554 ? -21.358 -55.037 -34.286 1.00 22.91  ? 817  TRP   A CA  1 
ATOM   4099 C  C   . TRP   A 1 554 ? -21.484 -55.474 -35.737 1.00 26.14  ? 817  TRP   A C   1 
ATOM   4100 O  O   . TRP   A 1 554 ? -20.460 -55.544 -36.369 1.00 25.49  ? 817  TRP   A O   1 
ATOM   4101 C  CB  . TRP   A 1 554 ? -20.790 -56.166 -33.424 1.00 24.93  ? 817  TRP   A CB  1 
ATOM   4102 C  CG  . TRP   A 1 554 ? -20.290 -55.660 -32.094 1.00 25.01  ? 817  TRP   A CG  1 
ATOM   4103 C  CD1 . TRP   A 1 554 ? -20.868 -55.777 -30.873 1.00 25.82  ? 817  TRP   A CD1 1 
ATOM   4104 C  CD2 . TRP   A 1 554 ? -19.066 -54.926 -31.886 1.00 24.17  ? 817  TRP   A CD2 1 
ATOM   4105 N  NE1 . TRP   A 1 554 ? -20.110 -55.148 -29.915 1.00 25.06  ? 817  TRP   A NE1 1 
ATOM   4106 C  CE2 . TRP   A 1 554 ? -18.979 -54.650 -30.506 1.00 23.88  ? 817  TRP   A CE2 1 
ATOM   4107 C  CE3 . TRP   A 1 554 ? -18.023 -54.533 -32.726 1.00 23.53  ? 817  TRP   A CE3 1 
ATOM   4108 C  CZ2 . TRP   A 1 554 ? -17.888 -53.988 -29.952 1.00 23.38  ? 817  TRP   A CZ2 1 
ATOM   4109 C  CZ3 . TRP   A 1 554 ? -16.944 -53.844 -32.173 1.00 24.21  ? 817  TRP   A CZ3 1 
ATOM   4110 C  CH2 . TRP   A 1 554 ? -16.887 -53.606 -30.808 1.00 22.55  ? 817  TRP   A CH2 1 
ATOM   4111 N  N   . ILE   A 1 555 ? -22.695 -55.750 -36.238 1.00 27.98  ? 818  ILE   A N   1 
ATOM   4112 C  CA  . ILE   A 1 555 ? -22.858 -56.228 -37.635 1.00 28.00  ? 818  ILE   A CA  1 
ATOM   4113 C  C   . ILE   A 1 555 ? -23.710 -55.216 -38.404 1.00 29.29  ? 818  ILE   A C   1 
ATOM   4114 O  O   . ILE   A 1 555 ? -23.149 -54.529 -39.271 1.00 29.70  ? 818  ILE   A O   1 
ATOM   4115 C  CB  . ILE   A 1 555 ? -23.477 -57.634 -37.678 1.00 29.38  ? 818  ILE   A CB  1 
ATOM   4116 C  CG1 . ILE   A 1 555 ? -22.709 -58.674 -36.871 1.00 30.16  ? 818  ILE   A CG1 1 
ATOM   4117 C  CG2 . ILE   A 1 555 ? -23.642 -58.087 -39.137 1.00 33.53  ? 818  ILE   A CG2 1 
ATOM   4118 C  CD1 . ILE   A 1 555 ? -21.297 -58.756 -37.172 1.00 32.08  ? 818  ILE   A CD1 1 
ATOM   4119 N  N   . GLN   A 1 556 ? -25.002 -55.091 -38.084 1.00 33.07  ? 819  GLN   A N   1 
ATOM   4120 C  CA  . GLN   A 1 556 ? -26.002 -54.415 -38.963 1.00 35.86  ? 819  GLN   A CA  1 
ATOM   4121 C  C   . GLN   A 1 556 ? -25.614 -52.938 -39.126 1.00 35.67  ? 819  GLN   A C   1 
ATOM   4122 O  O   . GLN   A 1 556 ? -25.536 -52.458 -40.277 1.00 33.85  ? 819  GLN   A O   1 
ATOM   4123 C  CB  . GLN   A 1 556 ? -27.402 -54.569 -38.359 1.00 42.36  ? 819  GLN   A CB  1 
ATOM   4124 C  CG  . GLN   A 1 556 ? -28.550 -54.058 -39.235 1.00 51.41  ? 819  GLN   A CG  1 
ATOM   4125 C  CD  . GLN   A 1 556 ? -29.809 -53.718 -38.455 1.00 60.72  ? 819  GLN   A CD  1 
ATOM   4126 O  OE1 . GLN   A 1 556 ? -30.410 -52.653 -38.628 1.00 71.18  ? 819  GLN   A OE1 1 
ATOM   4127 N  NE2 . GLN   A 1 556 ? -30.205 -54.587 -37.535 1.00 52.22  ? 819  GLN   A NE2 1 
ATOM   4128 N  N   . GLU   A 1 557 ? -25.341 -52.232 -38.026 1.00 28.71  ? 820  GLU   A N   1 
ATOM   4129 C  CA  . GLU   A 1 557 ? -25.122 -50.768 -38.051 1.00 29.73  ? 820  GLU   A CA  1 
ATOM   4130 C  C   . GLU   A 1 557 ? -23.620 -50.440 -38.074 1.00 31.80  ? 820  GLU   A C   1 
ATOM   4131 O  O   . GLU   A 1 557 ? -23.277 -49.254 -38.024 1.00 36.08  ? 820  GLU   A O   1 
ATOM   4132 C  CB  . GLU   A 1 557 ? -25.861 -50.115 -36.892 1.00 32.89  ? 820  GLU   A CB  1 
ATOM   4133 C  CG  . GLU   A 1 557 ? -27.352 -50.432 -36.919 1.00 41.27  ? 820  GLU   A CG  1 
ATOM   4134 C  CD  . GLU   A 1 557 ? -28.261 -49.763 -35.893 1.00 49.32  ? 820  GLU   A CD  1 
ATOM   4135 O  OE1 . GLU   A 1 557 ? -27.762 -49.221 -34.870 1.00 53.67  ? 820  GLU   A OE1 1 
ATOM   4136 O  OE2 . GLU   A 1 557 ? -29.505 -49.803 -36.120 1.00 62.95  ? 820  GLU   A OE2 1 
ATOM   4137 N  N   . ASN   A 1 558 ? -22.753 -51.439 -38.152 1.00 30.54  ? 821  ASN   A N   1 
ATOM   4138 C  CA  . ASN   A 1 558 ? -21.283 -51.220 -38.124 1.00 30.82  ? 821  ASN   A CA  1 
ATOM   4139 C  C   . ASN   A 1 558 ? -20.811 -50.838 -39.525 1.00 29.79  ? 821  ASN   A C   1 
ATOM   4140 O  O   . ASN   A 1 558 ? -20.712 -51.697 -40.384 1.00 31.36  ? 821  ASN   A O   1 
ATOM   4141 C  CB  . ASN   A 1 558 ? -20.602 -52.480 -37.617 1.00 31.93  ? 821  ASN   A CB  1 
ATOM   4142 C  CG  . ASN   A 1 558 ? -19.095 -52.403 -37.580 1.00 31.23  ? 821  ASN   A CG  1 
ATOM   4143 O  OD1 . ASN   A 1 558 ? -18.518 -51.398 -37.988 1.00 29.36  ? 821  ASN   A OD1 1 
ATOM   4144 N  ND2 . ASN   A 1 558 ? -18.476 -53.454 -37.044 1.00 26.95  ? 821  ASN   A ND2 1 
ATOM   4145 N  N   . PRO   A 1 559 ? -20.433 -49.574 -39.797 1.00 29.71  ? 822  PRO   A N   1 
ATOM   4146 C  CA  . PRO   A 1 559 ? -20.044 -49.194 -41.156 1.00 33.86  ? 822  PRO   A CA  1 
ATOM   4147 C  C   . PRO   A 1 559 ? -18.719 -49.807 -41.604 1.00 32.91  ? 822  PRO   A C   1 
ATOM   4148 O  O   . PRO   A 1 559 ? -18.421 -49.732 -42.763 1.00 33.55  ? 822  PRO   A O   1 
ATOM   4149 C  CB  . PRO   A 1 559 ? -19.951 -47.665 -41.115 1.00 35.44  ? 822  PRO   A CB  1 
ATOM   4150 C  CG  . PRO   A 1 559 ? -19.718 -47.339 -39.661 1.00 35.89  ? 822  PRO   A CG  1 
ATOM   4151 C  CD  . PRO   A 1 559 ? -20.423 -48.436 -38.870 1.00 34.46  ? 822  PRO   A CD  1 
ATOM   4152 N  N   . TRP   A 1 560 ? -17.948 -50.434 -40.707 1.00 31.08  ? 823  TRP   A N   1 
ATOM   4153 C  CA  . TRP   A 1 560 ? -16.682 -51.097 -41.109 1.00 31.58  ? 823  TRP   A CA  1 
ATOM   4154 C  C   . TRP   A 1 560 ? -16.891 -52.573 -41.454 1.00 34.23  ? 823  TRP   A C   1 
ATOM   4155 O  O   . TRP   A 1 560 ? -15.895 -53.197 -41.801 1.00 40.03  ? 823  TRP   A O   1 
ATOM   4156 C  CB  . TRP   A 1 560 ? -15.610 -50.926 -40.020 1.00 30.53  ? 823  TRP   A CB  1 
ATOM   4157 C  CG  . TRP   A 1 560 ? -15.165 -49.501 -39.896 1.00 29.91  ? 823  TRP   A CG  1 
ATOM   4158 C  CD1 . TRP   A 1 560 ? -14.202 -48.871 -40.636 1.00 29.86  ? 823  TRP   A CD1 1 
ATOM   4159 C  CD2 . TRP   A 1 560 ? -15.682 -48.518 -38.990 1.00 29.82  ? 823  TRP   A CD2 1 
ATOM   4160 N  NE1 . TRP   A 1 560 ? -14.083 -47.573 -40.229 1.00 30.86  ? 823  TRP   A NE1 1 
ATOM   4161 C  CE2 . TRP   A 1 560 ? -14.983 -47.326 -39.224 1.00 28.55  ? 823  TRP   A CE2 1 
ATOM   4162 C  CE3 . TRP   A 1 560 ? -16.615 -48.548 -37.958 1.00 27.23  ? 823  TRP   A CE3 1 
ATOM   4163 C  CZ2 . TRP   A 1 560 ? -15.192 -46.180 -38.461 1.00 29.94  ? 823  TRP   A CZ2 1 
ATOM   4164 C  CZ3 . TRP   A 1 560 ? -16.870 -47.406 -37.248 1.00 27.95  ? 823  TRP   A CZ3 1 
ATOM   4165 C  CH2 . TRP   A 1 560 ? -16.143 -46.233 -37.479 1.00 28.98  ? 823  TRP   A CH2 1 
ATOM   4166 N  N   . MET   A 1 561 ? -18.109 -53.110 -41.319 1.00 32.44  ? 824  MET   A N   1 
ATOM   4167 C  CA  . MET   A 1 561 ? -18.454 -54.542 -41.575 1.00 32.58  ? 824  MET   A CA  1 
ATOM   4168 C  C   . MET   A 1 561 ? -19.250 -54.615 -42.892 1.00 31.72  ? 824  MET   A C   1 
ATOM   4169 O  O   . MET   A 1 561 ? -20.398 -54.199 -42.900 1.00 33.29  ? 824  MET   A O   1 
ATOM   4170 C  CB  . MET   A 1 561 ? -19.298 -55.074 -40.408 1.00 33.04  ? 824  MET   A CB  1 
ATOM   4171 C  CG  . MET   A 1 561 ? -19.524 -56.591 -40.362 1.00 37.36  ? 824  MET   A CG  1 
ATOM   4172 S  SD  . MET   A 1 561 ? -18.004 -57.467 -40.124 1.00 47.65  ? 824  MET   A SD  1 
ATOM   4173 C  CE  . MET   A 1 561 ? -17.764 -57.245 -38.350 1.00 42.80  ? 824  MET   A CE  1 
ATOM   4174 N  N   . GLU   A 1 562 ? -18.657 -55.076 -43.988 1.00 35.26  ? 825  GLU   A N   1 
ATOM   4175 C  CA  . GLU   A 1 562 ? -19.370 -55.129 -45.297 1.00 43.10  ? 825  GLU   A CA  1 
ATOM   4176 C  C   . GLU   A 1 562 ? -20.366 -56.300 -45.308 1.00 37.54  ? 825  GLU   A C   1 
ATOM   4177 O  O   . GLU   A 1 562 ? -21.476 -56.119 -45.762 1.00 39.58  ? 825  GLU   A O   1 
ATOM   4178 C  CB  . GLU   A 1 562 ? -18.391 -55.211 -46.469 1.00 53.28  ? 825  GLU   A CB  1 
ATOM   4179 C  CG  . GLU   A 1 562 ? -19.067 -55.571 -47.785 1.00 67.37  ? 825  GLU   A CG  1 
ATOM   4180 C  CD  . GLU   A 1 562 ? -18.313 -55.143 -49.039 1.00 82.40  ? 825  GLU   A CD  1 
ATOM   4181 O  OE1 . GLU   A 1 562 ? -18.990 -54.893 -50.074 1.00 83.19  ? 825  GLU   A OE1 1 
ATOM   4182 O  OE2 . GLU   A 1 562 ? -17.054 -55.047 -48.984 1.00 90.70  ? 825  GLU   A OE2 1 
ATOM   4183 N  N   . ASP   A 1 563 ? -19.999 -57.459 -44.788 1.00 38.30  ? 826  ASP   A N   1 
ATOM   4184 C  CA  . ASP   A 1 563 ? -20.891 -58.640 -44.791 1.00 37.53  ? 826  ASP   A CA  1 
ATOM   4185 C  C   . ASP   A 1 563 ? -21.861 -58.511 -43.628 1.00 36.46  ? 826  ASP   A C   1 
ATOM   4186 O  O   . ASP   A 1 563 ? -21.376 -58.592 -42.476 1.00 39.55  ? 826  ASP   A O   1 
ATOM   4187 C  CB  . ASP   A 1 563 ? -20.035 -59.892 -44.685 1.00 33.68  ? 826  ASP   A CB  1 
ATOM   4188 C  CG  . ASP   A 1 563 ? -20.803 -61.194 -44.580 1.00 35.95  ? 826  ASP   A CG  1 
ATOM   4189 O  OD1 . ASP   A 1 563 ? -22.030 -61.151 -44.436 1.00 39.53  ? 826  ASP   A OD1 1 
ATOM   4190 O  OD2 . ASP   A 1 563 ? -20.141 -62.230 -44.560 1.00 41.85  ? 826  ASP   A OD2 1 
ATOM   4191 N  N   . LYS   A 1 564 ? -23.163 -58.448 -43.890 1.00 34.05  ? 827  LYS   A N   1 
ATOM   4192 C  CA  . LYS   A 1 564 ? -24.198 -58.223 -42.848 1.00 33.14  ? 827  LYS   A CA  1 
ATOM   4193 C  C   . LYS   A 1 564 ? -24.811 -59.537 -42.343 1.00 30.80  ? 827  LYS   A C   1 
ATOM   4194 O  O   . LYS   A 1 564 ? -25.875 -59.482 -41.686 1.00 33.07  ? 827  LYS   A O   1 
ATOM   4195 C  CB  . LYS   A 1 564 ? -25.262 -57.231 -43.329 1.00 34.40  ? 827  LYS   A CB  1 
ATOM   4196 C  CG  . LYS   A 1 564 ? -24.739 -55.853 -43.714 1.00 37.47  ? 827  LYS   A CG  1 
ATOM   4197 C  CD  . LYS   A 1 564 ? -23.966 -55.152 -42.614 1.00 32.20  ? 827  LYS   A CD  1 
ATOM   4198 C  CE  . LYS   A 1 564 ? -23.639 -53.724 -42.959 1.00 32.60  ? 827  LYS   A CE  1 
ATOM   4199 N  NZ  . LYS   A 1 564 ? -22.774 -53.124 -41.905 1.00 31.76  ? 827  LYS   A NZ  1 
ATOM   4200 N  N   . THR   A 1 565 ? -24.189 -60.678 -42.570 1.00 33.29  ? 828  THR   A N   1 
ATOM   4201 C  CA  . THR   A 1 565 ? -24.765 -61.978 -42.116 1.00 35.29  ? 828  THR   A CA  1 
ATOM   4202 C  C   . THR   A 1 565 ? -24.878 -61.974 -40.594 1.00 38.06  ? 828  THR   A C   1 
ATOM   4203 O  O   . THR   A 1 565 ? -23.847 -61.831 -39.938 1.00 33.52  ? 828  THR   A O   1 
ATOM   4204 C  CB  . THR   A 1 565 ? -23.873 -63.152 -42.524 1.00 39.89  ? 828  THR   A CB  1 
ATOM   4205 O  OG1 . THR   A 1 565 ? -23.708 -63.098 -43.941 1.00 38.37  ? 828  THR   A OG1 1 
ATOM   4206 C  CG2 . THR   A 1 565 ? -24.428 -64.488 -42.102 1.00 41.83  ? 828  THR   A CG2 1 
ATOM   4207 N  N   . PRO   A 1 566 ? -26.093 -62.131 -40.004 1.00 39.86  ? 829  PRO   A N   1 
ATOM   4208 C  CA  . PRO   A 1 566 ? -26.255 -62.109 -38.553 1.00 40.72  ? 829  PRO   A CA  1 
ATOM   4209 C  C   . PRO   A 1 566 ? -25.537 -63.303 -37.922 1.00 39.10  ? 829  PRO   A C   1 
ATOM   4210 O  O   . PRO   A 1 566 ? -25.316 -64.342 -38.537 1.00 32.95  ? 829  PRO   A O   1 
ATOM   4211 C  CB  . PRO   A 1 566 ? -27.779 -62.134 -38.321 1.00 42.68  ? 829  PRO   A CB  1 
ATOM   4212 C  CG  . PRO   A 1 566 ? -28.391 -61.842 -39.697 1.00 40.57  ? 829  PRO   A CG  1 
ATOM   4213 C  CD  . PRO   A 1 566 ? -27.381 -62.354 -40.688 1.00 39.76  ? 829  PRO   A CD  1 
ATOM   4214 N  N   . VAL   A 1 567 ? -25.107 -63.103 -36.686 1.00 35.79  ? 830  VAL   A N   1 
ATOM   4215 C  CA  . VAL   A 1 567 ? -24.548 -64.186 -35.850 1.00 35.98  ? 830  VAL   A CA  1 
ATOM   4216 C  C   . VAL   A 1 567 ? -25.732 -64.892 -35.178 1.00 34.34  ? 830  VAL   A C   1 
ATOM   4217 O  O   . VAL   A 1 567 ? -26.648 -64.185 -34.703 1.00 35.00  ? 830  VAL   A O   1 
ATOM   4218 C  CB  . VAL   A 1 567 ? -23.570 -63.533 -34.854 1.00 40.32  ? 830  VAL   A CB  1 
ATOM   4219 C  CG1 . VAL   A 1 567 ? -23.543 -64.258 -33.558 1.00 39.76  ? 830  VAL   A CG1 1 
ATOM   4220 C  CG2 . VAL   A 1 567 ? -22.191 -63.369 -35.454 1.00 39.08  ? 830  VAL   A CG2 1 
ATOM   4221 N  N   . GLU   A 1 568 ? -25.723 -66.223 -35.095 1.00 38.68  ? 831  GLU   A N   1 
ATOM   4222 C  CA  . GLU   A 1 568 ? -26.921 -67.005 -34.652 1.00 42.96  ? 831  GLU   A CA  1 
ATOM   4223 C  C   . GLU   A 1 568 ? -26.781 -67.362 -33.175 1.00 42.13  ? 831  GLU   A C   1 
ATOM   4224 O  O   . GLU   A 1 568 ? -27.810 -67.641 -32.540 1.00 37.00  ? 831  GLU   A O   1 
ATOM   4225 C  CB  . GLU   A 1 568 ? -27.092 -68.315 -35.440 1.00 45.74  ? 831  GLU   A CB  1 
ATOM   4226 C  CG  . GLU   A 1 568 ? -27.434 -68.133 -36.922 1.00 52.90  ? 831  GLU   A CG  1 
ATOM   4227 C  CD  . GLU   A 1 568 ? -28.743 -67.412 -37.230 1.00 52.45  ? 831  GLU   A CD  1 
ATOM   4228 O  OE1 . GLU   A 1 568 ? -29.689 -67.488 -36.418 1.00 56.53  ? 831  GLU   A OE1 1 
ATOM   4229 O  OE2 . GLU   A 1 568 ? -28.818 -66.770 -38.289 1.00 59.96  ? 831  GLU   A OE2 1 
ATOM   4230 N  N   . SER   A 1 569 ? -25.558 -67.400 -32.635 1.00 34.17  ? 832  SER   A N   1 
ATOM   4231 C  CA  . SER   A 1 569 ? -25.366 -67.728 -31.211 1.00 30.02  ? 832  SER   A CA  1 
ATOM   4232 C  C   . SER   A 1 569 ? -24.099 -67.062 -30.668 1.00 32.79  ? 832  SER   A C   1 
ATOM   4233 O  O   . SER   A 1 569 ? -23.225 -66.632 -31.459 1.00 32.54  ? 832  SER   A O   1 
ATOM   4234 C  CB  . SER   A 1 569 ? -25.304 -69.199 -31.002 1.00 35.29  ? 832  SER   A CB  1 
ATOM   4235 O  OG  . SER   A 1 569 ? -24.025 -69.688 -31.342 1.00 34.80  ? 832  SER   A OG  1 
ATOM   4236 N  N   . TRP   A 1 570 ? -24.021 -66.986 -29.351 1.00 30.81  ? 833  TRP   A N   1 
ATOM   4237 C  CA  . TRP   A 1 570 ? -22.822 -66.422 -28.659 1.00 32.54  ? 833  TRP   A CA  1 
ATOM   4238 C  C   . TRP   A 1 570 ? -21.565 -67.257 -28.984 1.00 33.76  ? 833  TRP   A C   1 
ATOM   4239 O  O   . TRP   A 1 570 ? -20.474 -66.696 -29.016 1.00 30.96  ? 833  TRP   A O   1 
ATOM   4240 C  CB  . TRP   A 1 570 ? -23.119 -66.345 -27.148 1.00 29.11  ? 833  TRP   A CB  1 
ATOM   4241 C  CG  . TRP   A 1 570 ? -23.969 -65.185 -26.795 1.00 28.87  ? 833  TRP   A CG  1 
ATOM   4242 C  CD1 . TRP   A 1 570 ? -25.319 -65.188 -26.583 1.00 29.63  ? 833  TRP   A CD1 1 
ATOM   4243 C  CD2 . TRP   A 1 570 ? -23.536 -63.802 -26.691 1.00 30.58  ? 833  TRP   A CD2 1 
ATOM   4244 N  NE1 . TRP   A 1 570 ? -25.742 -63.911 -26.332 1.00 32.86  ? 833  TRP   A NE1 1 
ATOM   4245 C  CE2 . TRP   A 1 570 ? -24.682 -63.040 -26.410 1.00 27.52  ? 833  TRP   A CE2 1 
ATOM   4246 C  CE3 . TRP   A 1 570 ? -22.300 -63.139 -26.793 1.00 32.36  ? 833  TRP   A CE3 1 
ATOM   4247 C  CZ2 . TRP   A 1 570 ? -24.620 -61.665 -26.153 1.00 32.78  ? 833  TRP   A CZ2 1 
ATOM   4248 C  CZ3 . TRP   A 1 570 ? -22.240 -61.772 -26.601 1.00 28.10  ? 833  TRP   A CZ3 1 
ATOM   4249 C  CH2 . TRP   A 1 570 ? -23.404 -61.042 -26.312 1.00 28.40  ? 833  TRP   A CH2 1 
ATOM   4250 N  N   . GLU   A 1 571 ? -21.672 -68.547 -29.322 1.00 33.07  ? 834  GLU   A N   1 
ATOM   4251 C  CA  . GLU   A 1 571 ? -20.470 -69.400 -29.597 1.00 38.98  ? 834  GLU   A CA  1 
ATOM   4252 C  C   . GLU   A 1 571 ? -19.747 -68.969 -30.881 1.00 35.31  ? 834  GLU   A C   1 
ATOM   4253 O  O   . GLU   A 1 571 ? -18.545 -69.239 -30.984 1.00 36.78  ? 834  GLU   A O   1 
ATOM   4254 C  CB  . GLU   A 1 571 ? -20.844 -70.889 -29.633 1.00 51.94  ? 834  GLU   A CB  1 
ATOM   4255 C  CG  . GLU   A 1 571 ? -21.719 -71.295 -28.449 1.00 64.84  ? 834  GLU   A CG  1 
ATOM   4256 C  CD  . GLU   A 1 571 ? -21.542 -72.692 -27.857 1.00 82.85  ? 834  GLU   A CD  1 
ATOM   4257 O  OE1 . GLU   A 1 571 ? -20.575 -73.398 -28.235 1.00 91.42  ? 834  GLU   A OE1 1 
ATOM   4258 O  OE2 . GLU   A 1 571 ? -22.382 -73.072 -26.993 1.00 95.08  ? 834  GLU   A OE2 1 
ATOM   4259 N  N   . GLU   A 1 572 ? -20.411 -68.285 -31.794 1.00 33.31  ? 835  GLU   A N   1 
ATOM   4260 C  CA  . GLU   A 1 572 ? -19.794 -67.671 -32.996 1.00 34.16  ? 835  GLU   A CA  1 
ATOM   4261 C  C   . GLU   A 1 572 ? -18.993 -66.392 -32.649 1.00 30.88  ? 835  GLU   A C   1 
ATOM   4262 O  O   . GLU   A 1 572 ? -18.356 -65.833 -33.560 1.00 32.97  ? 835  GLU   A O   1 
ATOM   4263 C  CB  . GLU   A 1 572 ? -20.839 -67.174 -34.010 1.00 36.29  ? 835  GLU   A CB  1 
ATOM   4264 C  CG  . GLU   A 1 572 ? -21.563 -68.246 -34.820 1.00 45.71  ? 835  GLU   A CG  1 
ATOM   4265 C  CD  . GLU   A 1 572 ? -22.541 -67.656 -35.855 1.00 48.42  ? 835  GLU   A CD  1 
ATOM   4266 O  OE1 . GLU   A 1 572 ? -22.096 -66.945 -36.800 1.00 48.08  ? 835  GLU   A OE1 1 
ATOM   4267 O  OE2 . GLU   A 1 572 ? -23.753 -67.828 -35.687 1.00 44.88  ? 835  GLU   A OE2 1 
ATOM   4268 N  N   . ILE   A 1 573 ? -19.149 -65.841 -31.449 1.00 28.58  ? 836  ILE   A N   1 
ATOM   4269 C  CA  . ILE   A 1 573 ? -18.549 -64.525 -31.091 1.00 27.01  ? 836  ILE   A CA  1 
ATOM   4270 C  C   . ILE   A 1 573 ? -17.239 -64.857 -30.374 1.00 28.13  ? 836  ILE   A C   1 
ATOM   4271 O  O   . ILE   A 1 573 ? -17.259 -65.535 -29.349 1.00 25.47  ? 836  ILE   A O   1 
ATOM   4272 C  CB  . ILE   A 1 573 ? -19.526 -63.698 -30.249 1.00 27.94  ? 836  ILE   A CB  1 
ATOM   4273 C  CG1 . ILE   A 1 573 ? -20.763 -63.313 -31.058 1.00 25.81  ? 836  ILE   A CG1 1 
ATOM   4274 C  CG2 . ILE   A 1 573 ? -18.819 -62.464 -29.673 1.00 30.25  ? 836  ILE   A CG2 1 
ATOM   4275 C  CD1 . ILE   A 1 573 ? -21.864 -62.667 -30.273 1.00 26.62  ? 836  ILE   A CD1 1 
ATOM   4276 N  N   . PRO   A 1 574 ? -16.080 -64.411 -30.897 1.00 28.82  ? 837  PRO   A N   1 
ATOM   4277 C  CA  . PRO   A 1 574 ? -14.771 -64.854 -30.412 1.00 27.22  ? 837  PRO   A CA  1 
ATOM   4278 C  C   . PRO   A 1 574 ? -14.299 -64.169 -29.114 1.00 23.89  ? 837  PRO   A C   1 
ATOM   4279 O  O   . PRO   A 1 574 ? -14.871 -63.181 -28.669 1.00 24.60  ? 837  PRO   A O   1 
ATOM   4280 C  CB  . PRO   A 1 574 ? -13.829 -64.431 -31.551 1.00 28.41  ? 837  PRO   A CB  1 
ATOM   4281 C  CG  . PRO   A 1 574 ? -14.465 -63.191 -32.089 1.00 31.06  ? 837  PRO   A CG  1 
ATOM   4282 C  CD  . PRO   A 1 574 ? -15.968 -63.401 -31.957 1.00 31.42  ? 837  PRO   A CD  1 
ATOM   4283 N  N   . TYR   A 1 575 ? -13.284 -64.771 -28.518 1.00 25.20  ? 838  TYR   A N   1 
ATOM   4284 C  CA  . TYR   A 1 575 ? -12.485 -64.193 -27.421 1.00 24.05  ? 838  TYR   A CA  1 
ATOM   4285 C  C   . TYR   A 1 575 ? -11.117 -63.743 -27.945 1.00 26.47  ? 838  TYR   A C   1 
ATOM   4286 O  O   . TYR   A 1 575 ? -10.640 -64.233 -29.016 1.00 22.72  ? 838  TYR   A O   1 
ATOM   4287 C  CB  . TYR   A 1 575 ? -12.297 -65.248 -26.337 1.00 25.61  ? 838  TYR   A CB  1 
ATOM   4288 C  CG  . TYR   A 1 575 ? -13.542 -65.755 -25.659 1.00 25.42  ? 838  TYR   A CG  1 
ATOM   4289 C  CD1 . TYR   A 1 575 ? -14.197 -65.011 -24.699 1.00 21.64  ? 838  TYR   A CD1 1 
ATOM   4290 C  CD2 . TYR   A 1 575 ? -14.003 -67.043 -25.888 1.00 31.82  ? 838  TYR   A CD2 1 
ATOM   4291 C  CE1 . TYR   A 1 575 ? -15.297 -65.502 -24.017 1.00 26.03  ? 838  TYR   A CE1 1 
ATOM   4292 C  CE2 . TYR   A 1 575 ? -15.109 -67.547 -25.223 1.00 34.12  ? 838  TYR   A CE2 1 
ATOM   4293 C  CZ  . TYR   A 1 575 ? -15.773 -66.761 -24.292 1.00 30.50  ? 838  TYR   A CZ  1 
ATOM   4294 O  OH  . TYR   A 1 575 ? -16.842 -67.241 -23.599 1.00 32.34  ? 838  TYR   A OH  1 
ATOM   4295 N  N   . LEU   A 1 576 ? -10.440 -62.875 -27.179 1.00 21.94  ? 839  LEU   A N   1 
ATOM   4296 C  CA  . LEU   A 1 576 ? -8.994  -62.636 -27.318 1.00 23.11  ? 839  LEU   A CA  1 
ATOM   4297 C  C   . LEU   A 1 576 ? -8.308  -64.008 -27.251 1.00 23.44  ? 839  LEU   A C   1 
ATOM   4298 O  O   . LEU   A 1 576 ? -8.878  -64.947 -26.619 1.00 22.68  ? 839  LEU   A O   1 
ATOM   4299 C  CB  . LEU   A 1 576 ? -8.504  -61.722 -26.175 1.00 25.60  ? 839  LEU   A CB  1 
ATOM   4300 C  CG  . LEU   A 1 576 ? -9.093  -60.308 -26.074 1.00 23.07  ? 839  LEU   A CG  1 
ATOM   4301 C  CD1 . LEU   A 1 576 ? -8.386  -59.455 -25.035 1.00 23.91  ? 839  LEU   A CD1 1 
ATOM   4302 C  CD2 . LEU   A 1 576 ? -9.025  -59.583 -27.391 1.00 25.83  ? 839  LEU   A CD2 1 
ATOM   4303 N  N   . GLY   A 1 577 ? -7.096  -64.110 -27.771 1.00 27.00  ? 840  GLY   A N   1 
ATOM   4304 C  CA  . GLY   A 1 577 ? -6.181  -65.217 -27.422 1.00 25.01  ? 840  GLY   A CA  1 
ATOM   4305 C  C   . GLY   A 1 577 ? -6.078  -65.403 -25.910 1.00 22.99  ? 840  GLY   A C   1 
ATOM   4306 O  O   . GLY   A 1 577 ? -6.171  -64.420 -25.128 1.00 22.11  ? 840  GLY   A O   1 
ATOM   4307 N  N   . LYS   A 1 578 ? -5.933  -66.661 -25.486 0.32 22.13  ? 841  LYS   A N   1 
ATOM   4308 C  CA  . LYS   A 1 578 ? -5.855  -67.057 -24.052 0.32 22.34  ? 841  LYS   A CA  1 
ATOM   4309 C  C   . LYS   A 1 578 ? -4.735  -66.272 -23.358 0.32 20.54  ? 841  LYS   A C   1 
ATOM   4310 O  O   . LYS   A 1 578 ? -4.970  -65.740 -22.270 0.32 20.03  ? 841  LYS   A O   1 
ATOM   4311 C  CB  . LYS   A 1 578 ? -5.598  -68.558 -23.915 0.32 22.95  ? 841  LYS   A CB  1 
ATOM   4312 C  CG  . LYS   A 1 578 ? -6.790  -69.466 -24.194 0.32 23.44  ? 841  LYS   A CG  1 
ATOM   4313 C  CD  . LYS   A 1 578 ? -6.481  -70.941 -23.946 0.32 25.13  ? 841  LYS   A CD  1 
ATOM   4314 C  CE  . LYS   A 1 578 ? -5.586  -71.556 -25.007 0.32 25.01  ? 841  LYS   A CE  1 
ATOM   4315 N  NZ  . LYS   A 1 578 ? -5.079  -72.890 -24.612 0.32 27.02  ? 841  LYS   A NZ  1 
ATOM   4316 N  N   . ARG   A 1 579 ? -3.555  -66.206 -23.973 0.32 19.30  ? 842  ARG   A N   1 
ATOM   4317 C  CA  . ARG   A 1 579 ? -2.370  -65.521 -23.400 0.32 18.60  ? 842  ARG   A CA  1 
ATOM   4318 C  C   . ARG   A 1 579 ? -2.663  -64.016 -23.308 0.32 18.55  ? 842  ARG   A C   1 
ATOM   4319 O  O   . ARG   A 1 579 ? -2.437  -63.437 -22.220 0.32 18.08  ? 842  ARG   A O   1 
ATOM   4320 C  CB  . ARG   A 1 579 ? -1.120  -65.808 -24.239 0.32 18.19  ? 842  ARG   A CB  1 
ATOM   4321 C  CG  . ARG   A 1 579 ? 0.150   -65.229 -23.632 0.32 18.06  ? 842  ARG   A CG  1 
ATOM   4322 C  CD  . ARG   A 1 579 ? 1.384   -65.508 -24.468 0.32 18.33  ? 842  ARG   A CD  1 
ATOM   4323 N  NE  . ARG   A 1 579 ? 1.747   -66.925 -24.460 0.32 18.27  ? 842  ARG   A NE  1 
ATOM   4324 C  CZ  . ARG   A 1 579 ? 2.436   -67.553 -23.513 0.32 17.54  ? 842  ARG   A CZ  1 
ATOM   4325 N  NH1 . ARG   A 1 579 ? 2.702   -68.840 -23.653 0.32 18.80  ? 842  ARG   A NH1 1 
ATOM   4326 N  NH2 . ARG   A 1 579 ? 2.845   -66.926 -22.427 0.32 17.98  ? 842  ARG   A NH2 1 
ATOM   4327 N  N   . GLU   A 1 580 ? -3.128  -63.417 -24.406 0.32 19.01  ? 843  GLU   A N   1 
ATOM   4328 C  CA  . GLU   A 1 580 ? -3.469  -61.964 -24.512 0.32 19.96  ? 843  GLU   A CA  1 
ATOM   4329 C  C   . GLU   A 1 580 ? -4.581  -61.602 -23.519 0.32 19.64  ? 843  GLU   A C   1 
ATOM   4330 O  O   . GLU   A 1 580 ? -4.559  -60.487 -22.978 0.32 19.79  ? 843  GLU   A O   1 
ATOM   4331 C  CB  . GLU   A 1 580 ? -3.956  -61.604 -25.916 0.32 19.75  ? 843  GLU   A CB  1 
ATOM   4332 C  CG  . GLU   A 1 580 ? -2.905  -61.710 -27.000 0.32 21.04  ? 843  GLU   A CG  1 
ATOM   4333 C  CD  . GLU   A 1 580 ? -3.488  -61.626 -28.401 0.32 22.39  ? 843  GLU   A CD  1 
ATOM   4334 O  OE1 . GLU   A 1 580 ? -4.315  -62.493 -28.740 0.32 23.90  ? 843  GLU   A OE1 1 
ATOM   4335 O  OE2 . GLU   A 1 580 ? -3.144  -60.684 -29.138 0.32 23.04  ? 843  GLU   A OE2 1 
ATOM   4336 N  N   . ASP   A 1 581 ? -5.546  -62.493 -23.319 0.32 19.58  ? 844  ASP   A N   1 
ATOM   4337 C  CA  . ASP   A 1 581 ? -6.644  -62.285 -22.337 0.32 20.36  ? 844  ASP   A CA  1 
ATOM   4338 C  C   . ASP   A 1 581 ? -6.012  -62.243 -20.939 0.32 20.69  ? 844  ASP   A C   1 
ATOM   4339 O  O   . ASP   A 1 581 ? -6.427  -61.405 -20.122 0.32 20.83  ? 844  ASP   A O   1 
ATOM   4340 C  CB  . ASP   A 1 581 ? -7.729  -63.354 -22.501 0.32 20.07  ? 844  ASP   A CB  1 
ATOM   4341 C  CG  . ASP   A 1 581 ? -9.096  -62.997 -21.935 0.32 20.37  ? 844  ASP   A CG  1 
ATOM   4342 O  OD1 . ASP   A 1 581 ? -9.191  -61.994 -21.195 0.32 20.58  ? 844  ASP   A OD1 1 
ATOM   4343 O  OD2 . ASP   A 1 581 ? -10.062 -63.739 -22.232 0.32 20.08  ? 844  ASP   A OD2 1 
ATOM   4344 N  N   . GLN   A 1 582 ? -4.996  -63.078 -20.696 0.32 21.34  ? 845  GLN   A N   1 
ATOM   4345 C  CA  . GLN   A 1 582 ? -4.237  -63.112 -19.416 0.32 21.39  ? 845  GLN   A CA  1 
ATOM   4346 C  C   . GLN   A 1 582 ? -3.371  -61.849 -19.277 0.32 20.45  ? 845  GLN   A C   1 
ATOM   4347 O  O   . GLN   A 1 582 ? -3.216  -61.373 -18.133 0.32 20.43  ? 845  GLN   A O   1 
ATOM   4348 C  CB  . GLN   A 1 582 ? -3.412  -64.403 -19.328 0.32 23.30  ? 845  GLN   A CB  1 
ATOM   4349 C  CG  . GLN   A 1 582 ? -2.760  -64.608 -17.969 0.32 25.00  ? 845  GLN   A CG  1 
ATOM   4350 C  CD  . GLN   A 1 582 ? -1.865  -65.822 -17.922 0.32 27.15  ? 845  GLN   A CD  1 
ATOM   4351 O  OE1 . GLN   A 1 582 ? -0.948  -65.970 -18.729 0.32 30.02  ? 845  GLN   A OE1 1 
ATOM   4352 N  NE2 . GLN   A 1 582 ? -2.122  -66.701 -16.965 0.32 27.75  ? 845  GLN   A NE2 1 
ATOM   4353 N  N   . TRP   A 1 583 ? -2.810  -61.325 -20.374 0.32 19.54  ? 846  TRP   A N   1 
ATOM   4354 C  CA  . TRP   A 1 583 ? -1.992  -60.076 -20.369 0.32 19.06  ? 846  TRP   A CA  1 
ATOM   4355 C  C   . TRP   A 1 583 ? -2.840  -58.896 -19.860 0.32 20.19  ? 846  TRP   A C   1 
ATOM   4356 O  O   . TRP   A 1 583 ? -2.296  -58.030 -19.139 0.32 19.26  ? 846  TRP   A O   1 
ATOM   4357 C  CB  . TRP   A 1 583 ? -1.410  -59.778 -21.761 0.32 19.02  ? 846  TRP   A CB  1 
ATOM   4358 C  CG  . TRP   A 1 583 ? -0.145  -60.518 -22.097 0.32 18.76  ? 846  TRP   A CG  1 
ATOM   4359 C  CD1 . TRP   A 1 583 ? 0.845   -60.886 -21.236 0.32 18.82  ? 846  TRP   A CD1 1 
ATOM   4360 C  CD2 . TRP   A 1 583 ? 0.283   -60.953 -23.402 0.32 18.75  ? 846  TRP   A CD2 1 
ATOM   4361 N  NE1 . TRP   A 1 583 ? 1.855   -61.525 -21.910 0.32 19.10  ? 846  TRP   A NE1 1 
ATOM   4362 C  CE2 . TRP   A 1 583 ? 1.535   -61.586 -23.238 0.32 18.78  ? 846  TRP   A CE2 1 
ATOM   4363 C  CE3 . TRP   A 1 583 ? -0.268  -60.883 -24.687 0.32 18.83  ? 846  TRP   A CE3 1 
ATOM   4364 C  CZ2 . TRP   A 1 583 ? 2.235   -62.136 -24.309 0.32 19.85  ? 846  TRP   A CZ2 1 
ATOM   4365 C  CZ3 . TRP   A 1 583 ? 0.429   -61.420 -25.746 0.32 19.11  ? 846  TRP   A CZ3 1 
ATOM   4366 C  CH2 . TRP   A 1 583 ? 1.655   -62.053 -25.555 0.32 19.29  ? 846  TRP   A CH2 1 
ATOM   4367 N  N   . CYS   A 1 584 ? -4.121  -58.870 -20.244 1.00 19.44  ? 847  CYS   A N   1 
ATOM   4368 C  CA  . CYS   A 1 584 ? -5.079  -57.793 -19.927 1.00 19.95  ? 847  CYS   A CA  1 
ATOM   4369 C  C   . CYS   A 1 584 ? -5.850  -58.051 -18.611 1.00 21.11  ? 847  CYS   A C   1 
ATOM   4370 O  O   . CYS   A 1 584 ? -6.870  -57.422 -18.420 1.00 20.58  ? 847  CYS   A O   1 
ATOM   4371 C  CB  . CYS   A 1 584 ? -5.959  -57.597 -21.143 1.00 20.44  ? 847  CYS   A CB  1 
ATOM   4372 S  SG  . CYS   A 1 584 ? -5.049  -56.780 -22.470 1.00 22.62  ? 847  CYS   A SG  1 
ATOM   4373 N  N   . GLY   A 1 585 ? -5.369  -58.986 -17.778 0.32 21.62  ? 848  GLY   A N   1 
ATOM   4374 C  CA  . GLY   A 1 585 ? -5.765  -59.148 -16.363 0.32 21.34  ? 848  GLY   A CA  1 
ATOM   4375 C  C   . GLY   A 1 585 ? -6.716  -60.310 -16.125 0.32 21.55  ? 848  GLY   A C   1 
ATOM   4376 O  O   . GLY   A 1 585 ? -7.275  -60.365 -15.021 0.32 23.24  ? 848  GLY   A O   1 
ATOM   4377 N  N   . SER   A 1 586 ? -6.896  -61.218 -17.095 1.00 22.32  ? 849  SER   A N   1 
ATOM   4378 C  CA  . SER   A 1 586 ? -7.732  -62.449 -16.901 1.00 22.00  ? 849  SER   A CA  1 
ATOM   4379 C  C   . SER   A 1 586 ? -7.159  -63.351 -15.791 1.00 24.38  ? 849  SER   A C   1 
ATOM   4380 O  O   . SER   A 1 586 ? -5.926  -63.503 -15.674 1.00 20.01  ? 849  SER   A O   1 
ATOM   4381 C  CB  . SER   A 1 586 ? -7.862  -63.273 -18.131 1.00 21.41  ? 849  SER   A CB  1 
ATOM   4382 O  OG  . SER   A 1 586 ? -8.789  -64.316 -17.931 1.00 21.48  ? 849  SER   A OG  1 
ATOM   4383 N  N   . LEU   A 1 587 ? -8.054  -63.965 -15.016 0.32 23.26  ? 850  LEU   A N   1 
ATOM   4384 C  CA  . LEU   A 1 587 ? -7.701  -64.903 -13.918 0.32 24.17  ? 850  LEU   A CA  1 
ATOM   4385 C  C   . LEU   A 1 587 ? -7.780  -66.357 -14.395 0.32 24.31  ? 850  LEU   A C   1 
ATOM   4386 O  O   . LEU   A 1 587 ? -7.669  -67.245 -13.524 0.32 24.87  ? 850  LEU   A O   1 
ATOM   4387 C  CB  . LEU   A 1 587 ? -8.638  -64.684 -12.722 0.32 24.67  ? 850  LEU   A CB  1 
ATOM   4388 C  CG  . LEU   A 1 587 ? -8.573  -63.324 -12.021 0.32 25.28  ? 850  LEU   A CG  1 
ATOM   4389 C  CD1 . LEU   A 1 587 ? -9.131  -63.441 -10.606 0.32 25.56  ? 850  LEU   A CD1 1 
ATOM   4390 C  CD2 . LEU   A 1 587 ? -7.159  -62.761 -11.982 0.32 25.72  ? 850  LEU   A CD2 1 
ATOM   4391 N  N   . ILE   A 1 588 ? -7.972  -66.613 -15.698 0.32 24.72  ? 851  ILE   A N   1 
ATOM   4392 C  CA  . ILE   A 1 588 ? -7.930  -68.002 -16.249 0.32 25.51  ? 851  ILE   A CA  1 
ATOM   4393 C  C   . ILE   A 1 588 ? -6.586  -68.633 -15.854 0.32 25.53  ? 851  ILE   A C   1 
ATOM   4394 O  O   . ILE   A 1 588 ? -5.556  -67.919 -15.852 0.32 23.81  ? 851  ILE   A O   1 
ATOM   4395 C  CB  . ILE   A 1 588 ? -8.152  -68.067 -17.778 0.32 25.46  ? 851  ILE   A CB  1 
ATOM   4396 C  CG1 . ILE   A 1 588 ? -7.198  -67.153 -18.550 0.32 25.46  ? 851  ILE   A CG1 1 
ATOM   4397 C  CG2 . ILE   A 1 588 ? -9.608  -67.801 -18.132 0.32 25.39  ? 851  ILE   A CG2 1 
ATOM   4398 C  CD1 . ILE   A 1 588 ? -7.183  -67.393 -20.046 0.32 25.49  ? 851  ILE   A CD1 1 
ATOM   4399 N  N   . GLY   A 1 589 ? -6.599  -69.927 -15.530 0.32 27.21  ? 852  GLY   A N   1 
ATOM   4400 C  CA  . GLY   A 1 589 ? -5.398  -70.677 -15.115 0.32 27.05  ? 852  GLY   A CA  1 
ATOM   4401 C  C   . GLY   A 1 589 ? -5.151  -70.573 -13.618 0.32 27.74  ? 852  GLY   A C   1 
ATOM   4402 O  O   . GLY   A 1 589 ? -4.146  -71.131 -13.151 0.32 26.09  ? 852  GLY   A O   1 
ATOM   4403 N  N   . LEU   A 1 590 ? -6.036  -69.907 -12.873 0.32 27.54  ? 853  LEU   A N   1 
ATOM   4404 C  CA  . LEU   A 1 590 ? -5.965  -69.848 -11.390 0.32 28.22  ? 853  LEU   A CA  1 
ATOM   4405 C  C   . LEU   A 1 590 ? -7.065  -70.743 -10.804 0.32 29.14  ? 853  LEU   A C   1 
ATOM   4406 O  O   . LEU   A 1 590 ? -8.244  -70.623 -11.222 0.32 25.65  ? 853  LEU   A O   1 
ATOM   4407 C  CB  . LEU   A 1 590 ? -6.082  -68.397 -10.916 0.32 28.67  ? 853  LEU   A CB  1 
ATOM   4408 C  CG  . LEU   A 1 590 ? -5.141  -67.394 -11.594 0.32 30.17  ? 853  LEU   A CG  1 
ATOM   4409 C  CD1 . LEU   A 1 590 ? -5.174  -66.056 -10.872 0.32 30.92  ? 853  LEU   A CD1 1 
ATOM   4410 C  CD2 . LEU   A 1 590 ? -3.712  -67.911 -11.664 0.32 30.02  ? 853  LEU   A CD2 1 
ATOM   4411 N  N   . THR   A 1 591 ? -6.677  -71.629 -9.882  0.32 29.10  ? 854  THR   A N   1 
ATOM   4412 C  CA  . THR   A 1 591 ? -7.584  -72.569 -9.173  0.32 30.19  ? 854  THR   A CA  1 
ATOM   4413 C  C   . THR   A 1 591 ? -8.801  -71.803 -8.643  0.32 28.79  ? 854  THR   A C   1 
ATOM   4414 O  O   . THR   A 1 591 ? -9.907  -72.370 -8.685  0.32 28.65  ? 854  THR   A O   1 
ATOM   4415 C  CB  . THR   A 1 591 ? -6.828  -73.310 -8.060  0.32 30.93  ? 854  THR   A CB  1 
ATOM   4416 O  OG1 . THR   A 1 591 ? -6.163  -74.401 -8.696  0.32 30.37  ? 854  THR   A OG1 1 
ATOM   4417 C  CG2 . THR   A 1 591 ? -7.720  -73.808 -6.942  0.32 31.71  ? 854  THR   A CG2 1 
ATOM   4418 N  N   . SER   A 1 592 ? -8.608  -70.585 -8.131  1.00 29.45  ? 855  SER   A N   1 
ATOM   4419 C  CA  . SER   A 1 592 ? -9.751  -69.746 -7.663  1.00 28.96  ? 855  SER   A CA  1 
ATOM   4420 C  C   . SER   A 1 592 ? -10.776 -69.555 -8.809  1.00 26.94  ? 855  SER   A C   1 
ATOM   4421 O  O   . SER   A 1 592 ? -12.013 -69.736 -8.558  1.00 26.59  ? 855  SER   A O   1 
ATOM   4422 C  CB  . SER   A 1 592 ? -9.336  -68.421 -7.072  1.00 30.55  ? 855  SER   A CB  1 
ATOM   4423 O  OG  . SER   A 1 592 ? -8.540  -67.625 -7.946  1.00 32.38  ? 855  SER   A OG  1 
ATOM   4424 N  N   . ARG   A 1 593 ? -10.299 -69.248 -10.013 1.00 28.03  ? 856  ARG   A N   1 
ATOM   4425 C  CA  . ARG   A 1 593 ? -11.176 -68.936 -11.182 1.00 26.14  ? 856  ARG   A CA  1 
ATOM   4426 C  C   . ARG   A 1 593 ? -11.845 -70.239 -11.640 1.00 28.21  ? 856  ARG   A C   1 
ATOM   4427 O  O   . ARG   A 1 593 ? -13.019 -70.204 -12.017 1.00 24.45  ? 856  ARG   A O   1 
ATOM   4428 C  CB  . ARG   A 1 593 ? -10.326 -68.275 -12.271 1.00 27.26  ? 856  ARG   A CB  1 
ATOM   4429 C  CG  . ARG   A 1 593 ? -11.064 -67.655 -13.446 1.00 26.79  ? 856  ARG   A CG  1 
ATOM   4430 C  CD  . ARG   A 1 593 ? -11.561 -68.667 -14.461 1.00 24.83  ? 856  ARG   A CD  1 
ATOM   4431 N  NE  . ARG   A 1 593 ? -12.107 -67.926 -15.583 1.00 25.62  ? 856  ARG   A NE  1 
ATOM   4432 C  CZ  . ARG   A 1 593 ? -12.922 -68.415 -16.522 1.00 27.42  ? 856  ARG   A CZ  1 
ATOM   4433 N  NH1 . ARG   A 1 593 ? -13.253 -69.695 -16.519 1.00 27.06  ? 856  ARG   A NH1 1 
ATOM   4434 N  NH2 . ARG   A 1 593 ? -13.423 -67.604 -17.461 1.00 26.28  ? 856  ARG   A NH2 1 
ATOM   4435 N  N   . ALA   A 1 594 ? -11.101 -71.348 -11.711 1.00 25.14  ? 857  ALA   A N   1 
ATOM   4436 C  CA  . ALA   A 1 594 ? -11.659 -72.669 -12.133 1.00 28.85  ? 857  ALA   A CA  1 
ATOM   4437 C  C   . ALA   A 1 594 ? -12.804 -73.093 -11.194 1.00 27.11  ? 857  ALA   A C   1 
ATOM   4438 O  O   . ALA   A 1 594 ? -13.833 -73.562 -11.672 1.00 26.47  ? 857  ALA   A O   1 
ATOM   4439 C  CB  . ALA   A 1 594 ? -10.580 -73.729 -12.178 1.00 31.08  ? 857  ALA   A CB  1 
ATOM   4440 N  N   . THR   A 1 595 ? -12.642 -72.904 -9.899  1.00 28.29  ? 858  THR   A N   1 
ATOM   4441 C  CA  . THR   A 1 595 ? -13.664 -73.316 -8.927  1.00 31.64  ? 858  THR   A CA  1 
ATOM   4442 C  C   . THR   A 1 595 ? -14.906 -72.415 -9.074  1.00 28.73  ? 858  THR   A C   1 
ATOM   4443 O  O   . THR   A 1 595 ? -16.062 -72.915 -9.033  1.00 26.03  ? 858  THR   A O   1 
ATOM   4444 C  CB  . THR   A 1 595 ? -13.135 -73.206 -7.500  1.00 35.65  ? 858  THR   A CB  1 
ATOM   4445 O  OG1 . THR   A 1 595 ? -11.910 -73.946 -7.451  1.00 43.69  ? 858  THR   A OG1 1 
ATOM   4446 C  CG2 . THR   A 1 595 ? -14.181 -73.716 -6.536  1.00 39.60  ? 858  THR   A CG2 1 
ATOM   4447 N  N   . TRP   A 1 596 ? -14.671 -71.115 -9.207  1.00 26.33  ? 859  TRP   A N   1 
ATOM   4448 C  CA  . TRP   A 1 596 ? -15.775 -70.141 -9.479  1.00 23.23  ? 859  TRP   A CA  1 
ATOM   4449 C  C   . TRP   A 1 596 ? -16.554 -70.590 -10.725 1.00 22.77  ? 859  TRP   A C   1 
ATOM   4450 O  O   . TRP   A 1 596 ? -17.794 -70.683 -10.662 1.00 25.99  ? 859  TRP   A O   1 
ATOM   4451 C  CB  . TRP   A 1 596 ? -15.131 -68.760 -9.608  1.00 24.38  ? 859  TRP   A CB  1 
ATOM   4452 C  CG  . TRP   A 1 596 ? -16.017 -67.663 -10.118 1.00 22.42  ? 859  TRP   A CG  1 
ATOM   4453 C  CD1 . TRP   A 1 596 ? -17.057 -67.095 -9.459  1.00 22.25  ? 859  TRP   A CD1 1 
ATOM   4454 C  CD2 . TRP   A 1 596 ? -15.885 -66.976 -11.371 1.00 22.91  ? 859  TRP   A CD2 1 
ATOM   4455 N  NE1 . TRP   A 1 596 ? -17.589 -66.085 -10.211 1.00 24.14  ? 859  TRP   A NE1 1 
ATOM   4456 C  CE2 . TRP   A 1 596 ? -16.906 -66.003 -11.399 1.00 22.05  ? 859  TRP   A CE2 1 
ATOM   4457 C  CE3 . TRP   A 1 596 ? -15.038 -67.114 -12.482 1.00 22.82  ? 859  TRP   A CE3 1 
ATOM   4458 C  CZ2 . TRP   A 1 596 ? -17.033 -65.095 -12.451 1.00 22.56  ? 859  TRP   A CZ2 1 
ATOM   4459 C  CZ3 . TRP   A 1 596 ? -15.169 -66.226 -13.529 1.00 24.56  ? 859  TRP   A CZ3 1 
ATOM   4460 C  CH2 . TRP   A 1 596 ? -16.158 -65.223 -13.498 1.00 24.21  ? 859  TRP   A CH2 1 
ATOM   4461 N  N   . ALA   A 1 597 ? -15.884 -70.820 -11.862 1.00 24.46  ? 860  ALA   A N   1 
ATOM   4462 C  CA  . ALA   A 1 597 ? -16.565 -71.158 -13.131 1.00 26.22  ? 860  ALA   A CA  1 
ATOM   4463 C  C   . ALA   A 1 597 ? -17.348 -72.472 -12.979 1.00 27.93  ? 860  ALA   A C   1 
ATOM   4464 O  O   . ALA   A 1 597 ? -18.522 -72.540 -13.355 1.00 29.54  ? 860  ALA   A O   1 
ATOM   4465 C  CB  . ALA   A 1 597 ? -15.591 -71.241 -14.280 1.00 25.40  ? 860  ALA   A CB  1 
ATOM   4466 N  N   . LYS   A 1 598 ? -16.714 -73.470 -12.385 1.00 29.90  ? 861  LYS   A N   1 
ATOM   4467 C  CA  . LYS   A 1 598 ? -17.330 -74.809 -12.195 1.00 34.86  ? 861  LYS   A CA  1 
ATOM   4468 C  C   . LYS   A 1 598 ? -18.608 -74.715 -11.366 1.00 32.25  ? 861  LYS   A C   1 
ATOM   4469 O  O   . LYS   A 1 598 ? -19.591 -75.377 -11.734 1.00 33.00  ? 861  LYS   A O   1 
ATOM   4470 C  CB  . LYS   A 1 598 ? -16.358 -75.740 -11.469 1.00 39.69  ? 861  LYS   A CB  1 
ATOM   4471 C  CG  . LYS   A 1 598 ? -16.769 -77.216 -11.431 1.00 52.59  ? 861  LYS   A CG  1 
ATOM   4472 C  CD  . LYS   A 1 598 ? -15.686 -78.129 -10.834 1.00 60.29  ? 861  LYS   A CD  1 
ATOM   4473 C  CE  . LYS   A 1 598 ? -15.639 -79.491 -11.505 1.00 76.61  ? 861  LYS   A CE  1 
ATOM   4474 N  NZ  . LYS   A 1 598 ? -16.992 -80.108 -11.600 1.00 73.67  ? 861  LYS   A NZ  1 
ATOM   4475 N  N   . ASN   A 1 599 ? -18.571 -73.968 -10.272 1.00 30.12  ? 862  ASN   A N   1 
ATOM   4476 C  CA  . ASN   A 1 599 ? -19.644 -73.865 -9.264  1.00 30.28  ? 862  ASN   A CA  1 
ATOM   4477 C  C   . ASN   A 1 599 ? -20.517 -72.615 -9.477  1.00 26.57  ? 862  ASN   A C   1 
ATOM   4478 O  O   . ASN   A 1 599 ? -21.218 -72.228 -8.541  1.00 28.75  ? 862  ASN   A O   1 
ATOM   4479 C  CB  . ASN   A 1 599 ? -19.036 -73.850 -7.861  1.00 30.47  ? 862  ASN   A CB  1 
ATOM   4480 C  CG  . ASN   A 1 599 ? -18.322 -75.144 -7.546  1.00 37.56  ? 862  ASN   A CG  1 
ATOM   4481 O  OD1 . ASN   A 1 599 ? -18.807 -76.221 -7.843  1.00 41.60  ? 862  ASN   A OD1 1 
ATOM   4482 N  ND2 . ASN   A 1 599 ? -17.178 -75.037 -6.932  1.00 43.43  ? 862  ASN   A ND2 1 
ATOM   4483 N  N   . ILE   A 1 600 ? -20.552 -72.034 -10.658 1.00 25.49  ? 863  ILE   A N   1 
ATOM   4484 C  CA  . ILE   A 1 600 ? -21.248 -70.723 -10.858 1.00 25.76  ? 863  ILE   A CA  1 
ATOM   4485 C  C   . ILE   A 1 600 ? -22.762 -70.819 -10.523 1.00 27.12  ? 863  ILE   A C   1 
ATOM   4486 O  O   . ILE   A 1 600 ? -23.338 -69.854 -9.994  1.00 23.41  ? 863  ILE   A O   1 
ATOM   4487 C  CB  . ILE   A 1 600 ? -20.951 -70.158 -12.251 1.00 23.51  ? 863  ILE   A CB  1 
ATOM   4488 C  CG1 . ILE   A 1 600 ? -21.264 -68.663 -12.344 1.00 26.06  ? 863  ILE   A CG1 1 
ATOM   4489 C  CG2 . ILE   A 1 600 ? -21.663 -70.908 -13.397 1.00 27.61  ? 863  ILE   A CG2 1 
ATOM   4490 C  CD1 . ILE   A 1 600 ? -20.380 -67.824 -11.527 1.00 23.26  ? 863  ILE   A CD1 1 
ATOM   4491 N  N   A GLN   A 1 601 ? -23.407 -71.956 -10.804 0.25 27.15  ? 864  GLN   A N   1 
ATOM   4492 N  N   B GLN   A 1 601 ? -23.402 -71.960 -10.803 0.25 27.28  ? 864  GLN   A N   1 
ATOM   4493 C  CA  A GLN   A 1 601 ? -24.866 -72.106 -10.539 0.25 28.17  ? 864  GLN   A CA  1 
ATOM   4494 C  CA  B GLN   A 1 601 ? -24.862 -72.124 -10.545 0.25 28.41  ? 864  GLN   A CA  1 
ATOM   4495 C  C   A GLN   A 1 601 ? -25.140 -71.952 -9.032  0.25 27.95  ? 864  GLN   A C   1 
ATOM   4496 C  C   B GLN   A 1 601 ? -25.141 -71.962 -9.039  0.25 28.13  ? 864  GLN   A C   1 
ATOM   4497 O  O   A GLN   A 1 601 ? -26.213 -71.413 -8.681  0.25 27.49  ? 864  GLN   A O   1 
ATOM   4498 O  O   B GLN   A 1 601 ? -26.216 -71.424 -8.694  0.25 27.73  ? 864  GLN   A O   1 
ATOM   4499 C  CB  A GLN   A 1 601 ? -25.399 -73.418 -11.110 0.25 29.18  ? 864  GLN   A CB  1 
ATOM   4500 C  CB  B GLN   A 1 601 ? -25.376 -73.446 -11.116 0.25 29.63  ? 864  GLN   A CB  1 
ATOM   4501 C  CG  A GLN   A 1 601 ? -25.364 -73.464 -12.631 0.25 29.58  ? 864  GLN   A CG  1 
ATOM   4502 C  CG  B GLN   A 1 601 ? -26.895 -73.524 -11.217 0.25 30.19  ? 864  GLN   A CG  1 
ATOM   4503 C  CD  A GLN   A 1 601 ? -26.342 -72.521 -13.288 0.25 30.24  ? 864  GLN   A CD  1 
ATOM   4504 C  CD  B GLN   A 1 601 ? -27.526 -72.302 -11.837 0.25 31.15  ? 864  GLN   A CD  1 
ATOM   4505 O  OE1 A GLN   A 1 601 ? -27.310 -72.067 -12.682 0.25 31.29  ? 864  GLN   A OE1 1 
ATOM   4506 O  OE1 B GLN   A 1 601 ? -27.258 -71.948 -12.985 0.25 31.16  ? 864  GLN   A OE1 1 
ATOM   4507 N  NE2 A GLN   A 1 601 ? -26.112 -72.247 -14.561 0.25 32.46  ? 864  GLN   A NE2 1 
ATOM   4508 N  NE2 B GLN   A 1 601 ? -28.381 -71.646 -11.068 0.25 31.65  ? 864  GLN   A NE2 1 
ATOM   4509 N  N   . THR   A 1 602 ? -24.208 -72.380 -8.177  1.00 26.29  ? 865  THR   A N   1 
ATOM   4510 C  CA  . THR   A 1 602 ? -24.323 -72.195 -6.708  1.00 30.42  ? 865  THR   A CA  1 
ATOM   4511 C  C   . THR   A 1 602 ? -24.312 -70.701 -6.336  1.00 29.53  ? 865  THR   A C   1 
ATOM   4512 O  O   . THR   A 1 602 ? -25.039 -70.307 -5.420  1.00 28.80  ? 865  THR   A O   1 
ATOM   4513 C  CB  . THR   A 1 602 ? -23.230 -72.990 -5.999  1.00 33.31  ? 865  THR   A CB  1 
ATOM   4514 O  OG1 . THR   A 1 602 ? -23.462 -74.345 -6.415  1.00 36.46  ? 865  THR   A OG1 1 
ATOM   4515 C  CG2 . THR   A 1 602 ? -23.277 -72.856 -4.501  1.00 36.64  ? 865  THR   A CG2 1 
ATOM   4516 N  N   . ALA   A 1 603 ? -23.521 -69.875 -7.020  1.00 28.42  ? 866  ALA   A N   1 
ATOM   4517 C  CA  . ALA   A 1 603 ? -23.383 -68.437 -6.735  1.00 24.52  ? 866  ALA   A CA  1 
ATOM   4518 C  C   . ALA   A 1 603 ? -24.646 -67.751 -7.231  1.00 24.69  ? 866  ALA   A C   1 
ATOM   4519 O  O   . ALA   A 1 603 ? -25.262 -66.948 -6.490  1.00 24.43  ? 866  ALA   A O   1 
ATOM   4520 C  CB  . ALA   A 1 603 ? -22.188 -67.906 -7.479  1.00 26.29  ? 866  ALA   A CB  1 
ATOM   4521 N  N   . ILE   A 1 604 ? -25.088 -68.169 -8.412  1.00 25.57  ? 867  ILE   A N   1 
ATOM   4522 C  CA  . ILE   A 1 604 ? -26.311 -67.596 -9.037  1.00 25.35  ? 867  ILE   A CA  1 
ATOM   4523 C  C   . ILE   A 1 604 ? -27.484 -67.870 -8.076  1.00 25.04  ? 867  ILE   A C   1 
ATOM   4524 O  O   . ILE   A 1 604 ? -28.259 -66.939 -7.784  1.00 24.08  ? 867  ILE   A O   1 
ATOM   4525 C  CB  . ILE   A 1 604 ? -26.526 -68.180 -10.434 1.00 26.76  ? 867  ILE   A CB  1 
ATOM   4526 C  CG1 . ILE   A 1 604 ? -25.495 -67.650 -11.435 1.00 25.72  ? 867  ILE   A CG1 1 
ATOM   4527 C  CG2 . ILE   A 1 604 ? -27.952 -67.903 -10.928 1.00 26.41  ? 867  ILE   A CG2 1 
ATOM   4528 C  CD1 . ILE   A 1 604 ? -25.452 -68.451 -12.709 1.00 28.68  ? 867  ILE   A CD1 1 
ATOM   4529 N  N   . ASN   A 1 605 ? -27.558 -69.093 -7.556  1.00 28.74  ? 868  ASN   A N   1 
ATOM   4530 C  CA  . ASN   A 1 605 ? -28.644 -69.537 -6.635  1.00 29.64  ? 868  ASN   A CA  1 
ATOM   4531 C  C   . ASN   A 1 605 ? -28.563 -68.792 -5.297  1.00 27.95  ? 868  ASN   A C   1 
ATOM   4532 O  O   . ASN   A 1 605 ? -29.651 -68.493 -4.752  1.00 26.85  ? 868  ASN   A O   1 
ATOM   4533 C  CB  . ASN   A 1 605 ? -28.662 -71.058 -6.459  1.00 30.69  ? 868  ASN   A CB  1 
ATOM   4534 C  CG  . ASN   A 1 605 ? -29.190 -71.768 -7.692  1.00 34.35  ? 868  ASN   A CG  1 
ATOM   4535 O  OD1 . ASN   A 1 605 ? -29.838 -71.190 -8.566  1.00 40.81  ? 868  ASN   A OD1 1 
ATOM   4536 N  ND2 . ASN   A 1 605 ? -28.925 -73.046 -7.768  1.00 39.83  ? 868  ASN   A ND2 1 
ATOM   4537 N  N   . GLN   A 1 606 ? -27.366 -68.447 -4.800  1.00 27.28  ? 869  GLN   A N   1 
ATOM   4538 C  CA  . GLN   A 1 606 ? -27.260 -67.646 -3.573  1.00 24.53  ? 869  GLN   A CA  1 
ATOM   4539 C  C   . GLN   A 1 606 ? -27.970 -66.313 -3.809  1.00 25.68  ? 869  GLN   A C   1 
ATOM   4540 O  O   . GLN   A 1 606 ? -28.709 -65.831 -2.892  1.00 28.22  ? 869  GLN   A O   1 
ATOM   4541 C  CB  . GLN   A 1 606 ? -25.812 -67.390 -3.122  1.00 28.34  ? 869  GLN   A CB  1 
ATOM   4542 C  CG  . GLN   A 1 606 ? -25.710 -66.596 -1.824  1.00 32.40  ? 869  GLN   A CG  1 
ATOM   4543 C  CD  . GLN   A 1 606 ? -24.286 -66.322 -1.375  1.00 37.14  ? 869  GLN   A CD  1 
ATOM   4544 O  OE1 . GLN   A 1 606 ? -23.368 -66.185 -2.195  1.00 33.90  ? 869  GLN   A OE1 1 
ATOM   4545 N  NE2 . GLN   A 1 606 ? -24.089 -66.232 -0.067  1.00 31.10  ? 869  GLN   A NE2 1 
ATOM   4546 N  N   . VAL   A 1 607 ? -27.638 -65.624 -4.907  1.00 23.66  ? 870  VAL   A N   1 
ATOM   4547 C  CA  . VAL   A 1 607 ? -28.233 -64.297 -5.176  1.00 23.23  ? 870  VAL   A CA  1 
ATOM   4548 C  C   . VAL   A 1 607 ? -29.754 -64.447 -5.437  1.00 23.99  ? 870  VAL   A C   1 
ATOM   4549 O  O   . VAL   A 1 607 ? -30.524 -63.629 -4.895  1.00 23.61  ? 870  VAL   A O   1 
ATOM   4550 C  CB  . VAL   A 1 607 ? -27.496 -63.596 -6.328  1.00 24.36  ? 870  VAL   A CB  1 
ATOM   4551 C  CG1 . VAL   A 1 607 ? -28.227 -62.330 -6.714  1.00 23.68  ? 870  VAL   A CG1 1 
ATOM   4552 C  CG2 . VAL   A 1 607 ? -26.043 -63.324 -5.923  1.00 25.08  ? 870  VAL   A CG2 1 
ATOM   4553 N  N   . ARG   A 1 608 ? -30.193 -65.466 -6.194  1.00 25.31  ? 871  ARG   A N   1 
ATOM   4554 C  CA  . ARG   A 1 608 ? -31.654 -65.681 -6.434  1.00 29.70  ? 871  ARG   A CA  1 
ATOM   4555 C  C   . ARG   A 1 608 ? -32.402 -65.841 -5.102  1.00 28.67  ? 871  ARG   A C   1 
ATOM   4556 O  O   . ARG   A 1 608 ? -33.500 -65.262 -4.972  1.00 29.65  ? 871  ARG   A O   1 
ATOM   4557 C  CB  . ARG   A 1 608 ? -31.869 -66.894 -7.330  1.00 26.87  ? 871  ARG   A CB  1 
ATOM   4558 C  CG  . ARG   A 1 608 ? -31.469 -66.668 -8.781  1.00 26.40  ? 871  ARG   A CG  1 
ATOM   4559 C  CD  . ARG   A 1 608 ? -31.834 -67.925 -9.541  1.00 27.86  ? 871  ARG   A CD  1 
ATOM   4560 N  NE  . ARG   A 1 608 ? -31.647 -67.768 -10.964 1.00 29.81  ? 871  ARG   A NE  1 
ATOM   4561 C  CZ  . ARG   A 1 608 ? -31.563 -68.778 -11.815 1.00 33.49  ? 871  ARG   A CZ  1 
ATOM   4562 N  NH1 . ARG   A 1 608 ? -31.671 -70.029 -11.383 1.00 37.72  ? 871  ARG   A NH1 1 
ATOM   4563 N  NH2 . ARG   A 1 608 ? -31.378 -68.543 -13.099 1.00 29.88  ? 871  ARG   A NH2 1 
ATOM   4564 N  N   . SER   A 1 609 ? -31.814 -66.581 -4.165  1.00 28.22  ? 872  SER   A N   1 
ATOM   4565 C  CA  . SER   A 1 609 ? -32.389 -66.837 -2.818  1.00 27.90  ? 872  SER   A CA  1 
ATOM   4566 C  C   . SER   A 1 609 ? -32.510 -65.523 -2.056  1.00 25.42  ? 872  SER   A C   1 
ATOM   4567 O  O   . SER   A 1 609 ? -33.468 -65.353 -1.275  1.00 26.04  ? 872  SER   A O   1 
ATOM   4568 C  CB  . SER   A 1 609 ? -31.625 -67.877 -2.033  1.00 28.38  ? 872  SER   A CB  1 
ATOM   4569 O  OG  . SER   A 1 609 ? -31.656 -69.147 -2.690  1.00 29.68  ? 872  SER   A OG  1 
ATOM   4570 N  N   . LEU   A 1 610 ? -31.550 -64.607 -2.175  1.00 25.82  ? 873  LEU   A N   1 
ATOM   4571 C  CA  . LEU   A 1 610 ? -31.633 -63.307 -1.475  1.00 23.79  ? 873  LEU   A CA  1 
ATOM   4572 C  C   . LEU   A 1 610 ? -32.758 -62.459 -2.088  1.00 26.52  ? 873  LEU   A C   1 
ATOM   4573 O  O   . LEU   A 1 610 ? -33.492 -61.749 -1.368  1.00 25.51  ? 873  LEU   A O   1 
ATOM   4574 C  CB  . LEU   A 1 610 ? -30.251 -62.644 -1.547  1.00 26.12  ? 873  LEU   A CB  1 
ATOM   4575 C  CG  . LEU   A 1 610 ? -29.132 -63.304 -0.750  1.00 24.33  ? 873  LEU   A CG  1 
ATOM   4576 C  CD1 . LEU   A 1 610 ? -27.776 -62.649 -1.039  1.00 30.41  ? 873  LEU   A CD1 1 
ATOM   4577 C  CD2 . LEU   A 1 610 ? -29.418 -63.252 0.743   1.00 27.82  ? 873  LEU   A CD2 1 
ATOM   4578 N  N   . ILE   A 1 611 ? -32.860 -62.433 -3.412  1.00 27.78  ? 874  ILE   A N   1 
ATOM   4579 C  CA  . ILE   A 1 611 ? -33.822 -61.542 -4.117  1.00 25.10  ? 874  ILE   A CA  1 
ATOM   4580 C  C   . ILE   A 1 611 ? -35.244 -62.108 -3.907  1.00 29.47  ? 874  ILE   A C   1 
ATOM   4581 O  O   . ILE   A 1 611 ? -36.201 -61.305 -3.703  1.00 28.64  ? 874  ILE   A O   1 
ATOM   4582 C  CB  . ILE   A 1 611 ? -33.433 -61.411 -5.613  1.00 27.85  ? 874  ILE   A CB  1 
ATOM   4583 C  CG1 . ILE   A 1 611 ? -32.114 -60.648 -5.744  1.00 26.19  ? 874  ILE   A CG1 1 
ATOM   4584 C  CG2 . ILE   A 1 611 ? -34.544 -60.680 -6.379  1.00 29.29  ? 874  ILE   A CG2 1 
ATOM   4585 C  CD1 . ILE   A 1 611 ? -31.609 -60.430 -7.125  1.00 26.60  ? 874  ILE   A CD1 1 
ATOM   4586 N  N   . GLY   A 1 612 ? -35.381 -63.429 -3.981  1.00 26.87  ? 875  GLY   A N   1 
ATOM   4587 C  CA  . GLY   A 1 612 ? -36.605 -64.189 -3.629  1.00 32.96  ? 875  GLY   A CA  1 
ATOM   4588 C  C   . GLY   A 1 612 ? -37.244 -64.865 -4.833  1.00 34.24  ? 875  GLY   A C   1 
ATOM   4589 O  O   . GLY   A 1 612 ? -36.646 -64.958 -5.884  1.00 30.03  ? 875  GLY   A O   1 
ATOM   4590 N  N   . ASN   A 1 613 ? -38.534 -65.145 -4.739  1.00 39.42  ? 876  ASN   A N   1 
ATOM   4591 C  CA  . ASN   A 1 613 ? -39.274 -65.967 -5.731  1.00 40.10  ? 876  ASN   A CA  1 
ATOM   4592 C  C   . ASN   A 1 613 ? -39.771 -65.082 -6.893  1.00 43.36  ? 876  ASN   A C   1 
ATOM   4593 O  O   . ASN   A 1 613 ? -40.888 -64.562 -6.840  1.00 51.48  ? 876  ASN   A O   1 
ATOM   4594 C  CB  . ASN   A 1 613 ? -40.398 -66.686 -4.986  1.00 49.61  ? 876  ASN   A CB  1 
ATOM   4595 C  CG  . ASN   A 1 613 ? -41.101 -67.703 -5.854  1.00 57.54  ? 876  ASN   A CG  1 
ATOM   4596 O  OD1 . ASN   A 1 613 ? -40.487 -68.298 -6.729  1.00 52.45  ? 876  ASN   A OD1 1 
ATOM   4597 N  ND2 . ASN   A 1 613 ? -42.369 -67.951 -5.563  1.00 65.45  ? 876  ASN   A ND2 1 
ATOM   4598 N  N   . GLU   A 1 614 ? -38.979 -64.975 -7.945  1.00 32.66  ? 877  GLU   A N   1 
ATOM   4599 C  CA  . GLU   A 1 614 ? -39.138 -64.019 -9.041  1.00 29.50  ? 877  GLU   A CA  1 
ATOM   4600 C  C   . GLU   A 1 614 ? -38.959 -64.842 -10.300 1.00 28.83  ? 877  GLU   A C   1 
ATOM   4601 O  O   . GLU   A 1 614 ? -38.665 -66.034 -10.191 1.00 31.83  ? 877  GLU   A O   1 
ATOM   4602 C  CB  . GLU   A 1 614 ? -38.070 -62.914 -8.973  1.00 31.59  ? 877  GLU   A CB  1 
ATOM   4603 C  CG  . GLU   A 1 614 ? -38.264 -61.941 -7.842  1.00 28.97  ? 877  GLU   A CG  1 
ATOM   4604 C  CD  . GLU   A 1 614 ? -39.486 -61.044 -7.844  1.00 31.18  ? 877  GLU   A CD  1 
ATOM   4605 O  OE1 . GLU   A 1 614 ? -40.101 -60.780 -8.907  1.00 30.87  ? 877  GLU   A OE1 1 
ATOM   4606 O  OE2 . GLU   A 1 614 ? -39.729 -60.490 -6.766  1.00 31.55  ? 877  GLU   A OE2 1 
ATOM   4607 N  N   . GLU   A 1 615 ? -39.149 -64.265 -11.462 1.00 33.26  ? 878  GLU   A N   1 
ATOM   4608 C  CA  . GLU   A 1 615 ? -38.964 -65.086 -12.693 1.00 37.82  ? 878  GLU   A CA  1 
ATOM   4609 C  C   . GLU   A 1 615 ? -37.525 -64.828 -13.130 1.00 35.23  ? 878  GLU   A C   1 
ATOM   4610 O  O   . GLU   A 1 615 ? -37.228 -63.649 -13.427 1.00 33.68  ? 878  GLU   A O   1 
ATOM   4611 C  CB  . GLU   A 1 615 ? -39.926 -64.711 -13.834 1.00 42.81  ? 878  GLU   A CB  1 
ATOM   4612 C  CG  . GLU   A 1 615 ? -39.810 -65.660 -15.031 1.00 54.43  ? 878  GLU   A CG  1 
ATOM   4613 C  CD  . GLU   A 1 615 ? -40.558 -65.257 -16.307 1.00 69.86  ? 878  GLU   A CD  1 
ATOM   4614 O  OE1 . GLU   A 1 615 ? -41.477 -64.366 -16.245 1.00 60.01  ? 878  GLU   A OE1 1 
ATOM   4615 O  OE2 . GLU   A 1 615 ? -40.228 -65.836 -17.383 1.00 77.25  ? 878  GLU   A OE2 1 
ATOM   4616 N  N   . TYR   A 1 616 ? -36.721 -65.884 -13.251 1.00 35.88  ? 879  TYR   A N   1 
ATOM   4617 C  CA  . TYR   A 1 616 ? -35.316 -65.824 -13.723 1.00 36.26  ? 879  TYR   A CA  1 
ATOM   4618 C  C   . TYR   A 1 616 ? -35.145 -66.694 -14.971 1.00 40.83  ? 879  TYR   A C   1 
ATOM   4619 O  O   . TYR   A 1 616 ? -35.925 -67.637 -15.141 1.00 34.88  ? 879  TYR   A O   1 
ATOM   4620 C  CB  . TYR   A 1 616 ? -34.376 -66.321 -12.630 1.00 37.59  ? 879  TYR   A CB  1 
ATOM   4621 C  CG  . TYR   A 1 616 ? -34.494 -65.647 -11.286 1.00 31.69  ? 879  TYR   A CG  1 
ATOM   4622 C  CD1 . TYR   A 1 616 ? -33.718 -64.554 -10.947 1.00 26.10  ? 879  TYR   A CD1 1 
ATOM   4623 C  CD2 . TYR   A 1 616 ? -35.350 -66.171 -10.315 1.00 31.61  ? 879  TYR   A CD2 1 
ATOM   4624 C  CE1 . TYR   A 1 616 ? -33.790 -63.992 -9.667  1.00 28.50  ? 879  TYR   A CE1 1 
ATOM   4625 C  CE2 . TYR   A 1 616 ? -35.439 -65.623 -9.040  1.00 27.44  ? 879  TYR   A CE2 1 
ATOM   4626 C  CZ  . TYR   A 1 616 ? -34.637 -64.543 -8.711  1.00 27.89  ? 879  TYR   A CZ  1 
ATOM   4627 O  OH  . TYR   A 1 616 ? -34.724 -64.024 -7.452  1.00 28.58  ? 879  TYR   A OH  1 
ATOM   4628 N  N   . THR   A 1 617 ? -34.175 -66.340 -15.827 1.00 36.88  ? 880  THR   A N   1 
ATOM   4629 C  CA  . THR   A 1 617 ? -33.677 -67.114 -17.005 1.00 38.32  ? 880  THR   A CA  1 
ATOM   4630 C  C   . THR   A 1 617 ? -32.251 -67.617 -16.732 1.00 36.03  ? 880  THR   A C   1 
ATOM   4631 O  O   . THR   A 1 617 ? -31.463 -66.867 -16.106 1.00 32.90  ? 880  THR   A O   1 
ATOM   4632 C  CB  . THR   A 1 617 ? -33.688 -66.208 -18.240 1.00 46.78  ? 880  THR   A CB  1 
ATOM   4633 O  OG1 . THR   A 1 617 ? -34.999 -65.632 -18.304 1.00 39.21  ? 880  THR   A OG1 1 
ATOM   4634 C  CG2 . THR   A 1 617 ? -33.318 -66.928 -19.523 1.00 44.25  ? 880  THR   A CG2 1 
ATOM   4635 N  N   . ASP   A 1 618 ? -31.922 -68.844 -17.146 1.00 33.77  ? 881  ASP   A N   1 
ATOM   4636 C  CA  . ASP   A 1 618 ? -30.523 -69.340 -17.089 1.00 38.77  ? 881  ASP   A CA  1 
ATOM   4637 C  C   . ASP   A 1 618 ? -29.828 -68.926 -18.397 1.00 38.52  ? 881  ASP   A C   1 
ATOM   4638 O  O   . ASP   A 1 618 ? -30.123 -69.523 -19.452 1.00 32.59  ? 881  ASP   A O   1 
ATOM   4639 C  CB  . ASP   A 1 618 ? -30.484 -70.851 -16.820 1.00 43.86  ? 881  ASP   A CB  1 
ATOM   4640 C  CG  . ASP   A 1 618 ? -29.086 -71.476 -16.763 1.00 46.64  ? 881  ASP   A CG  1 
ATOM   4641 O  OD1 . ASP   A 1 618 ? -28.069 -70.729 -16.600 1.00 39.99  ? 881  ASP   A OD1 1 
ATOM   4642 O  OD2 . ASP   A 1 618 ? -29.014 -72.711 -16.871 1.00 48.25  ? 881  ASP   A OD2 1 
ATOM   4643 N  N   . TYR   A 1 619 ? -28.910 -67.957 -18.350 1.00 34.96  ? 882  TYR   A N   1 
ATOM   4644 C  CA  . TYR   A 1 619 ? -28.102 -67.580 -19.544 1.00 32.45  ? 882  TYR   A CA  1 
ATOM   4645 C  C   . TYR   A 1 619 ? -26.813 -68.408 -19.644 1.00 37.14  ? 882  TYR   A C   1 
ATOM   4646 O  O   . TYR   A 1 619 ? -26.115 -68.243 -20.660 1.00 36.19  ? 882  TYR   A O   1 
ATOM   4647 C  CB  . TYR   A 1 619 ? -27.811 -66.084 -19.505 1.00 34.88  ? 882  TYR   A CB  1 
ATOM   4648 C  CG  . TYR   A 1 619 ? -29.061 -65.274 -19.676 1.00 36.82  ? 882  TYR   A CG  1 
ATOM   4649 C  CD1 . TYR   A 1 619 ? -29.690 -65.214 -20.919 1.00 36.41  ? 882  TYR   A CD1 1 
ATOM   4650 C  CD2 . TYR   A 1 619 ? -29.629 -64.600 -18.617 1.00 30.16  ? 882  TYR   A CD2 1 
ATOM   4651 C  CE1 . TYR   A 1 619 ? -30.856 -64.493 -21.108 1.00 35.73  ? 882  TYR   A CE1 1 
ATOM   4652 C  CE2 . TYR   A 1 619 ? -30.790 -63.854 -18.794 1.00 32.27  ? 882  TYR   A CE2 1 
ATOM   4653 C  CZ  . TYR   A 1 619 ? -31.407 -63.805 -20.035 1.00 36.24  ? 882  TYR   A CZ  1 
ATOM   4654 O  OH  . TYR   A 1 619 ? -32.519 -63.043 -20.203 1.00 37.35  ? 882  TYR   A OH  1 
ATOM   4655 N  N   . MET   A 1 620 ? -26.465 -69.257 -18.669 1.00 38.09  ? 883  MET   A N   1 
ATOM   4656 C  CA  . MET   A 1 620 ? -25.152 -69.972 -18.708 1.00 36.47  ? 883  MET   A CA  1 
ATOM   4657 C  C   . MET   A 1 620 ? -25.032 -70.932 -19.909 1.00 38.42  ? 883  MET   A C   1 
ATOM   4658 O  O   . MET   A 1 620 ? -23.964 -70.938 -20.520 1.00 44.92  ? 883  MET   A O   1 
ATOM   4659 C  CB  . MET   A 1 620 ? -24.773 -70.688 -17.408 1.00 36.02  ? 883  MET   A CB  1 
ATOM   4660 C  CG  . MET   A 1 620 ? -24.787 -69.806 -16.149 1.00 33.41  ? 883  MET   A CG  1 
ATOM   4661 S  SD  . MET   A 1 620 ? -24.042 -68.129 -16.292 1.00 33.88  ? 883  MET   A SD  1 
ATOM   4662 C  CE  . MET   A 1 620 ? -22.297 -68.500 -16.426 1.00 30.68  ? 883  MET   A CE  1 
ATOM   4663 N  N   . PRO   A 1 621 ? -26.041 -71.744 -20.327 1.00 43.82  ? 884  PRO   A N   1 
ATOM   4664 C  CA  . PRO   A 1 621 ? -25.903 -72.610 -21.515 1.00 52.30  ? 884  PRO   A CA  1 
ATOM   4665 C  C   . PRO   A 1 621 ? -25.634 -71.939 -22.878 1.00 55.52  ? 884  PRO   A C   1 
ATOM   4666 O  O   . PRO   A 1 621 ? -25.339 -72.701 -23.803 1.00 52.84  ? 884  PRO   A O   1 
ATOM   4667 C  CB  . PRO   A 1 621 ? -27.253 -73.363 -21.620 1.00 52.19  ? 884  PRO   A CB  1 
ATOM   4668 C  CG  . PRO   A 1 621 ? -27.831 -73.308 -20.216 1.00 51.82  ? 884  PRO   A CG  1 
ATOM   4669 C  CD  . PRO   A 1 621 ? -27.323 -71.991 -19.637 1.00 53.56  ? 884  PRO   A CD  1 
ATOM   4670 N  N   . SER   A 1 622 ? -25.704 -70.589 -22.981 1.00 53.50  ? 885  SER   A N   1 
ATOM   4671 C  CA  . SER   A 1 622 ? -25.179 -69.784 -24.134 1.00 54.57  ? 885  SER   A CA  1 
ATOM   4672 C  C   . SER   A 1 622 ? -23.648 -69.972 -24.286 1.00 57.31  ? 885  SER   A C   1 
ATOM   4673 O  O   . SER   A 1 622 ? -23.101 -69.625 -25.383 1.00 53.41  ? 885  SER   A O   1 
ATOM   4674 C  CB  . SER   A 1 622 ? -25.569 -68.294 -24.049 1.00 56.84  ? 885  SER   A CB  1 
ATOM   4675 O  OG  . SER   A 1 622 ? -24.946 -67.591 -22.963 1.00 42.78  ? 885  SER   A OG  1 
ATOM   4676 N  N   . MET   A 1 623 ? -22.972 -70.506 -23.251 1.00 49.02  ? 886  MET   A N   1 
ATOM   4677 C  CA  . MET   A 1 623 ? -21.506 -70.769 -23.237 1.00 61.11  ? 886  MET   A CA  1 
ATOM   4678 C  C   . MET   A 1 623 ? -21.270 -72.273 -23.434 1.00 63.61  ? 886  MET   A C   1 
ATOM   4679 O  O   . MET   A 1 623 ? -21.944 -73.057 -22.711 1.00 57.05  ? 886  MET   A O   1 
ATOM   4680 C  CB  . MET   A 1 623 ? -20.869 -70.342 -21.908 1.00 60.41  ? 886  MET   A CB  1 
ATOM   4681 C  CG  . MET   A 1 623 ? -21.476 -69.097 -21.308 1.00 60.63  ? 886  MET   A CG  1 
ATOM   4682 S  SD  . MET   A 1 623 ? -20.490 -68.450 -19.911 1.00 49.42  ? 886  MET   A SD  1 
ATOM   4683 C  CE  . MET   A 1 623 ? -19.081 -67.781 -20.761 1.00 40.28  ? 886  MET   A CE  1 
ATOM   4684 N  N   . LYS   A 1 624 ? -20.336 -72.646 -24.326 1.00 66.21  ? 887  LYS   A N   1 
ATOM   4685 C  CA  . LYS   A 1 624 ? -20.046 -74.063 -24.705 1.00 75.19  ? 887  LYS   A CA  1 
ATOM   4686 C  C   . LYS   A 1 624 ? -19.915 -74.958 -23.458 1.00 74.20  ? 887  LYS   A C   1 
ATOM   4687 O  O   . LYS   A 1 624 ? -20.518 -76.059 -23.465 1.00 69.14  ? 887  LYS   A O   1 
ATOM   4688 C  CB  . LYS   A 1 624 ? -18.774 -74.195 -25.558 1.00 78.66  ? 887  LYS   A CB  1 
ATOM   4689 C  CG  . LYS   A 1 624 ? -18.498 -75.622 -26.040 1.00 85.93  ? 887  LYS   A CG  1 
ATOM   4690 C  CD  . LYS   A 1 624 ? -17.598 -75.748 -27.263 1.00 91.09  ? 887  LYS   A CD  1 
ATOM   4691 C  CE  . LYS   A 1 624 ? -16.120 -75.792 -26.929 1.00 95.41  ? 887  LYS   A CE  1 
ATOM   4692 N  NZ  . LYS   A 1 624 ? -15.597 -74.451 -26.571 1.00 94.04  ? 887  LYS   A NZ  1 
ATOM   4693 N  N   . ARG   A 1 625 ? -19.165 -74.514 -22.436 1.00 69.57  ? 888  ARG   A N   1 
ATOM   4694 C  CA  . ARG   A 1 625 ? -18.804 -75.335 -21.238 1.00 70.41  ? 888  ARG   A CA  1 
ATOM   4695 C  C   . ARG   A 1 625 ? -20.047 -75.704 -20.401 1.00 68.48  ? 888  ARG   A C   1 
ATOM   4696 O  O   . ARG   A 1 625 ? -19.981 -76.748 -19.746 1.00 62.91  ? 888  ARG   A O   1 
ATOM   4697 C  CB  . ARG   A 1 625 ? -17.733 -74.646 -20.374 1.00 66.76  ? 888  ARG   A CB  1 
ATOM   4698 C  CG  . ARG   A 1 625 ? -18.146 -73.344 -19.692 1.00 64.80  ? 888  ARG   A CG  1 
ATOM   4699 C  CD  . ARG   A 1 625 ? -17.154 -72.894 -18.610 1.00 64.07  ? 888  ARG   A CD  1 
ATOM   4700 N  NE  . ARG   A 1 625 ? -17.021 -73.894 -17.545 1.00 64.83  ? 888  ARG   A NE  1 
ATOM   4701 C  CZ  . ARG   A 1 625 ? -15.945 -74.106 -16.779 1.00 57.44  ? 888  ARG   A CZ  1 
ATOM   4702 N  NH1 . ARG   A 1 625 ? -14.845 -73.374 -16.909 1.00 62.08  ? 888  ARG   A NH1 1 
ATOM   4703 N  NH2 . ARG   A 1 625 ? -15.980 -75.066 -15.870 1.00 53.31  ? 888  ARG   A NH2 1 
ATOM   4704 N  N   . PHE   A 1 626 ? -21.111 -74.880 -20.381 1.00 73.69  ? 889  PHE   A N   1 
ATOM   4705 C  CA  . PHE   A 1 626 ? -22.375 -75.115 -19.611 1.00 70.11  ? 889  PHE   A CA  1 
ATOM   4706 C  C   . PHE   A 1 626 ? -23.455 -75.679 -20.555 1.00 78.04  ? 889  PHE   A C   1 
ATOM   4707 O  O   . PHE   A 1 626 ? -24.536 -76.139 -20.100 1.00 66.22  ? 889  PHE   A O   1 
ATOM   4708 C  CB  . PHE   A 1 626 ? -22.834 -73.832 -18.896 1.00 63.60  ? 889  PHE   A CB  1 
ATOM   4709 C  CG  . PHE   A 1 626 ? -21.791 -73.206 -17.992 1.00 68.10  ? 889  PHE   A CG  1 
ATOM   4710 C  CD1 . PHE   A 1 626 ? -21.380 -73.842 -16.821 1.00 61.54  ? 889  PHE   A CD1 1 
ATOM   4711 C  CD2 . PHE   A 1 626 ? -21.202 -71.987 -18.318 1.00 58.47  ? 889  PHE   A CD2 1 
ATOM   4712 C  CE1 . PHE   A 1 626 ? -20.388 -73.289 -16.015 1.00 70.43  ? 889  PHE   A CE1 1 
ATOM   4713 C  CE2 . PHE   A 1 626 ? -20.224 -71.427 -17.503 1.00 62.78  ? 889  PHE   A CE2 1 
ATOM   4714 C  CZ  . PHE   A 1 626 ? -19.813 -72.077 -16.352 1.00 58.25  ? 889  PHE   A CZ  1 
ATOM   4715 N  N   . ARG   A 1 627 ? -23.196 -75.634 -21.860 1.00 82.37  ? 890  ARG   A N   1 
ATOM   4716 C  CA  . ARG   A 1 627 ? -24.064 -76.274 -22.875 1.00 102.45 ? 890  ARG   A CA  1 
ATOM   4717 C  C   . ARG   A 1 627 ? -23.695 -77.767 -22.901 1.00 116.98 ? 890  ARG   A C   1 
ATOM   4718 O  O   . ARG   A 1 627 ? -23.022 -78.188 -23.860 1.00 131.50 ? 890  ARG   A O   1 
ATOM   4719 C  CB  . ARG   A 1 627 ? -23.902 -75.537 -24.210 1.00 102.47 ? 890  ARG   A CB  1 
ATOM   4720 C  CG  . ARG   A 1 627 ? -25.118 -75.599 -25.125 1.00 102.14 ? 890  ARG   A CG  1 
ATOM   4721 C  CD  . ARG   A 1 627 ? -24.841 -74.986 -26.487 1.00 102.86 ? 890  ARG   A CD  1 
ATOM   4722 N  NE  . ARG   A 1 627 ? -23.473 -75.253 -26.926 1.00 100.97 ? 890  ARG   A NE  1 
ATOM   4723 C  CZ  . ARG   A 1 627 ? -23.057 -76.320 -27.611 1.00 98.36  ? 890  ARG   A CZ  1 
ATOM   4724 N  NH1 . ARG   A 1 627 ? -23.902 -77.265 -27.987 1.00 106.26 ? 890  ARG   A NH1 1 
ATOM   4725 N  NH2 . ARG   A 1 627 ? -21.781 -76.434 -27.933 1.00 96.71  ? 890  ARG   A NH2 1 
ATOM   4726 N  N   . ARG   A 1 628 ? -24.064 -78.511 -21.843 1.00 127.02 ? 891  ARG   A N   1 
ATOM   4727 C  CA  . ARG   A 1 628 ? -23.955 -79.997 -21.725 1.00 126.69 ? 891  ARG   A CA  1 
ATOM   4728 C  C   . ARG   A 1 628 ? -22.528 -80.473 -22.034 1.00 118.96 ? 891  ARG   A C   1 
ATOM   4729 O  O   . ARG   A 1 628 ? -21.531 -79.831 -21.707 1.00 115.55 ? 891  ARG   A O   1 
ATOM   4730 C  CB  . ARG   A 1 628 ? -24.958 -80.668 -22.671 1.00 128.53 ? 891  ARG   A CB  1 
ATOM   4731 C  CG  . ARG   A 1 628 ? -26.404 -80.239 -22.458 1.00 122.93 ? 891  ARG   A CG  1 
ATOM   4732 C  CD  . ARG   A 1 628 ? -26.858 -80.449 -21.027 1.00 122.41 ? 891  ARG   A CD  1 
ATOM   4733 N  NE  . ARG   A 1 628 ? -26.645 -81.825 -20.591 1.00 123.67 ? 891  ARG   A NE  1 
ATOM   4734 C  CZ  . ARG   A 1 628 ? -26.785 -82.266 -19.343 1.00 119.28 ? 891  ARG   A CZ  1 
ATOM   4735 N  NH1 . ARG   A 1 628 ? -27.133 -81.442 -18.370 1.00 122.47 ? 891  ARG   A NH1 1 
ATOM   4736 N  NH2 . ARG   A 1 628 ? -26.573 -83.540 -19.069 1.00 117.90 ? 891  ARG   A NH2 1 
HETATM 4737 ZN ZN  . ZN    B 2 .   ? -6.536  -55.633 -23.826 1.00 21.24  2 1001 ZN    A ZN  1 
HETATM 4738 ZN ZN  . ZN    C 2 .   ? -26.022 -14.946 -13.422 1.00 50.48  2 1002 ZN    A ZN  1 
HETATM 4739 O  O1  A MES   D 3 .   ? -28.498 -57.830 0.512   0.25 30.00  ? 1003 MES   A O1  1 
HETATM 4740 O  O1  B MES   D 3 .   ? -28.157 -57.696 0.224   0.25 630.90 ? 1003 MES   A O1  1 
HETATM 4741 C  C2  A MES   D 3 .   ? -27.875 -58.363 1.673   0.25 27.48  ? 1003 MES   A C2  1 
HETATM 4742 C  C2  B MES   D 3 .   ? -27.501 -58.248 1.356   0.25 637.78 ? 1003 MES   A C2  1 
HETATM 4743 C  C3  A MES   D 3 .   ? -26.423 -57.958 1.740   0.25 27.91  ? 1003 MES   A C3  1 
HETATM 4744 C  C3  B MES   D 3 .   ? -26.004 -58.254 1.176   0.25 639.12 ? 1003 MES   A C3  1 
HETATM 4745 N  N4  A MES   D 3 .   ? -25.696 -58.448 0.532   0.25 24.68  ? 1003 MES   A N4  1 
HETATM 4746 N  N4  B MES   D 3 .   ? -25.644 -59.042 -0.043  0.25 638.36 ? 1003 MES   A N4  1 
HETATM 4747 C  C5  A MES   D 3 .   ? -26.397 -58.000 -0.708  0.25 27.30  ? 1003 MES   A C5  1 
HETATM 4748 C  C5  B MES   D 3 .   ? -26.373 -58.468 -1.215  0.25 626.27 ? 1003 MES   A C5  1 
HETATM 4749 C  C6  A MES   D 3 .   ? -27.873 -58.322 -0.664  0.25 29.05  ? 1003 MES   A C6  1 
HETATM 4750 C  C6  B MES   D 3 .   ? -27.854 -58.456 -0.936  0.25 621.43 ? 1003 MES   A C6  1 
HETATM 4751 C  C7  A MES   D 3 .   ? -24.259 -58.002 0.541   0.25 24.91  ? 1003 MES   A C7  1 
HETATM 4752 C  C7  B MES   D 3 .   ? -24.162 -59.090 -0.280  0.25 648.01 ? 1003 MES   A C7  1 
HETATM 4753 C  C8  A MES   D 3 .   ? -23.335 -58.940 -0.215  0.25 25.29  ? 1003 MES   A C8  1 
HETATM 4754 C  C8  B MES   D 3 .   ? -23.396 -57.994 0.433   0.25 655.04 ? 1003 MES   A C8  1 
HETATM 4755 S  S   A MES   D 3 .   ? -21.601 -58.500 -0.039  0.25 26.01  ? 1003 MES   A S   1 
HETATM 4756 S  S   B MES   D 3 .   ? -21.641 -58.284 0.422   0.25 661.84 ? 1003 MES   A S   1 
HETATM 4757 O  O1S A MES   D 3 .   ? -21.240 -58.822 1.288   0.25 21.55  ? 1003 MES   A O1S 1 
HETATM 4758 O  O1S B MES   D 3 .   ? -21.474 -59.709 0.358   0.25 664.30 ? 1003 MES   A O1S 1 
HETATM 4759 O  O2S A MES   D 3 .   ? -20.930 -59.284 -1.063  0.25 24.98  ? 1003 MES   A O2S 1 
HETATM 4760 O  O2S B MES   D 3 .   ? -21.133 -57.617 -0.743  0.25 650.77 ? 1003 MES   A O2S 1 
HETATM 4761 O  O3S A MES   D 3 .   ? -21.531 -57.086 -0.355  0.25 24.15  ? 1003 MES   A O3S 1 
HETATM 4762 O  O3S B MES   D 3 .   ? -21.134 -57.724 1.643   0.25 661.36 ? 1003 MES   A O3S 1 
HETATM 4763 S  S   . DMS   E 4 .   ? -26.964 -62.368 -21.016 1.00 46.59  ? 1004 DMS   A S   1 
HETATM 4764 O  O   . DMS   E 4 .   ? -26.660 -62.907 -22.489 1.00 51.45  ? 1004 DMS   A O   1 
HETATM 4765 C  C1  . DMS   E 4 .   ? -28.175 -61.113 -21.199 1.00 39.70  ? 1004 DMS   A C1  1 
HETATM 4766 C  C2  . DMS   E 4 .   ? -25.574 -61.284 -20.721 1.00 50.87  ? 1004 DMS   A C2  1 
HETATM 4767 S  S   . DMS   F 4 .   ? -15.892 -69.867 -28.933 1.00 119.22 ? 1005 DMS   A S   1 
HETATM 4768 O  O   . DMS   F 4 .   ? -16.400 -68.437 -29.146 1.00 70.92  ? 1005 DMS   A O   1 
HETATM 4769 C  C1  . DMS   F 4 .   ? -16.818 -70.538 -27.559 1.00 99.35  ? 1005 DMS   A C1  1 
HETATM 4770 C  C2  . DMS   F 4 .   ? -14.293 -69.762 -28.149 1.00 95.28  ? 1005 DMS   A C2  1 
HETATM 4771 S  S   . DMS   G 4 .   ? -23.158 -48.330 -16.339 1.00 62.53  ? 1006 DMS   A S   1 
HETATM 4772 O  O   . DMS   G 4 .   ? -24.195 -48.035 -17.410 1.00 54.49  ? 1006 DMS   A O   1 
HETATM 4773 C  C1  . DMS   G 4 .   ? -21.684 -47.542 -16.902 1.00 61.88  ? 1006 DMS   A C1  1 
HETATM 4774 C  C2  . DMS   G 4 .   ? -22.643 -49.959 -16.624 1.00 45.57  ? 1006 DMS   A C2  1 
HETATM 4775 C  C1  . PEG   H 5 .   ? -30.897 -47.380 -25.277 1.00 101.60 ? 1007 PEG   A C1  1 
HETATM 4776 O  O1  . PEG   H 5 .   ? -30.318 -47.216 -26.558 1.00 99.31  ? 1007 PEG   A O1  1 
HETATM 4777 C  C2  . PEG   H 5 .   ? -31.289 -46.071 -24.655 1.00 108.65 ? 1007 PEG   A C2  1 
HETATM 4778 O  O2  . PEG   H 5 .   ? -31.686 -46.275 -23.300 1.00 105.88 ? 1007 PEG   A O2  1 
HETATM 4779 C  C3  . PEG   H 5 .   ? -31.863 -45.062 -22.569 1.00 109.74 ? 1007 PEG   A C3  1 
HETATM 4780 C  C4  . PEG   H 5 .   ? -30.534 -44.573 -22.051 1.00 107.73 ? 1007 PEG   A C4  1 
HETATM 4781 O  O4  . PEG   H 5 .   ? -30.473 -44.524 -20.634 1.00 91.57  ? 1007 PEG   A O4  1 
HETATM 4782 P  P   . PO4   I 6 .   ? -4.116  -39.721 -24.205 1.00 58.06  ? 1008 PO4   A P   1 
HETATM 4783 O  O1  . PO4   I 6 .   ? -2.757  -40.494 -23.554 1.00 36.34  ? 1008 PO4   A O1  1 
HETATM 4784 O  O2  . PO4   I 6 .   ? -3.733  -38.222 -24.877 1.00 37.59  ? 1008 PO4   A O2  1 
HETATM 4785 O  O3  . PO4   I 6 .   ? -4.813  -40.570 -25.442 1.00 38.59  ? 1008 PO4   A O3  1 
HETATM 4786 O  O4  . PO4   I 6 .   ? -5.076  -39.601 -23.102 1.00 55.43  ? 1008 PO4   A O4  1 
HETATM 4787 P  P   . PO4   J 6 .   ? -18.737 -9.945  -29.993 1.00 108.80 ? 1009 PO4   A P   1 
HETATM 4788 O  O1  . PO4   J 6 .   ? -17.691 -10.023 -28.831 1.00 77.22  ? 1009 PO4   A O1  1 
HETATM 4789 O  O2  . PO4   J 6 .   ? -18.023 -9.824  -31.375 1.00 70.10  ? 1009 PO4   A O2  1 
HETATM 4790 O  O3  . PO4   J 6 .   ? -19.614 -11.253 -30.010 1.00 66.30  ? 1009 PO4   A O3  1 
HETATM 4791 O  O4  . PO4   J 6 .   ? -19.628 -8.676  -29.767 1.00 79.80  ? 1009 PO4   A O4  1 
HETATM 4792 C  C1  . PEG   K 5 .   ? -16.600 -44.026 -41.117 1.00 68.16  ? 1010 PEG   A C1  1 
HETATM 4793 O  O1  . PEG   K 5 .   ? -17.995 -44.239 -41.142 1.00 65.99  ? 1010 PEG   A O1  1 
HETATM 4794 C  C2  . PEG   K 5 .   ? -15.943 -44.565 -42.331 1.00 71.14  ? 1010 PEG   A C2  1 
HETATM 4795 O  O2  . PEG   K 5 .   ? -16.425 -45.884 -42.574 1.00 75.26  ? 1010 PEG   A O2  1 
HETATM 4796 C  C3  . PEG   K 5 .   ? -16.257 -46.307 -43.921 1.00 74.21  ? 1010 PEG   A C3  1 
HETATM 4797 C  C4  . PEG   K 5 .   ? -15.174 -47.333 -43.993 1.00 76.16  ? 1010 PEG   A C4  1 
HETATM 4798 O  O4  . PEG   K 5 .   ? -15.612 -48.511 -44.637 1.00 67.86  ? 1010 PEG   A O4  1 
HETATM 4799 N  N1  . A1BZP L 7 .   ? -3.410  -73.707 -16.211 0.32 48.53  ? 1011 A1BZP A N1  1 
HETATM 4800 C  C4  . A1BZP L 7 .   ? -1.960  -72.638 -17.941 0.32 48.36  ? 1011 A1BZP A C4  1 
HETATM 4801 C  C5  . A1BZP L 7 .   ? -4.312  -73.672 -18.166 0.32 47.43  ? 1011 A1BZP A C5  1 
HETATM 4802 C  C6  . A1BZP L 7 .   ? -4.526  -70.716 -19.846 0.32 51.36  ? 1011 A1BZP A C6  1 
HETATM 4803 C  C7  . A1BZP L 7 .   ? -4.682  -69.867 -18.763 0.32 50.88  ? 1011 A1BZP A C7  1 
HETATM 4804 C  C8  . A1BZP L 7 .   ? -3.892  -68.735 -18.676 0.32 51.02  ? 1011 A1BZP A C8  1 
HETATM 4805 C  C10 . A1BZP L 7 .   ? -2.846  -69.313 -20.710 0.32 50.99  ? 1011 A1BZP A C10 1 
HETATM 4806 N  N   . A1BZP L 7 .   ? -4.622  -74.306 -16.041 0.32 47.31  ? 1011 A1BZP A N   1 
HETATM 4807 C  C   . A1BZP L 7 .   ? -6.540  -74.903 -17.439 0.32 45.75  ? 1011 A1BZP A C   1 
HETATM 4808 O  O   . A1BZP L 7 .   ? -6.582  -72.042 -19.011 0.32 48.12  ? 1011 A1BZP A O   1 
HETATM 4809 C  C1  . A1BZP L 7 .   ? -5.192  -74.295 -17.235 0.32 46.75  ? 1011 A1BZP A C1  1 
HETATM 4810 C  C11 . A1BZP L 7 .   ? -3.602  -70.453 -20.845 0.32 51.14  ? 1011 A1BZP A C11 1 
HETATM 4811 C  C2  . A1BZP L 7 .   ? -2.522  -73.558 -15.065 0.32 47.96  ? 1011 A1BZP A C2  1 
HETATM 4812 C  C3  . A1BZP L 7 .   ? -3.200  -73.322 -17.474 0.32 48.39  ? 1011 A1BZP A C3  1 
HETATM 4813 C  C9  . A1BZP L 7 .   ? -2.961  -68.447 -19.659 0.32 49.49  ? 1011 A1BZP A C9  1 
HETATM 4814 F  F   . A1BZP L 7 .   ? -1.930  -69.036 -21.677 0.32 48.27  ? 1011 A1BZP A F   1 
HETATM 4815 N  N2  . A1BZP L 7 .   ? -4.593  -73.414 -19.530 0.32 50.33  ? 1011 A1BZP A N2  1 
HETATM 4816 O  O1  . A1BZP L 7 .   ? -5.864  -72.343 -21.359 0.32 49.33  ? 1011 A1BZP A O1  1 
HETATM 4817 S  S   . A1BZP L 7 .   ? -5.537  -72.150 -19.981 0.32 52.13  ? 1011 A1BZP A S   1 
HETATM 4818 CL CL  . CL    M 8 .   ? 4.151   -49.196 -29.942 1.00 40.53  ? 1012 CL    A CL  1 
HETATM 4819 O  O   . HOH   N 9 .   ? -5.381  -15.650 -28.995 0.50 33.82  ? 1101 HOH   A O   1 
HETATM 4820 O  O   . HOH   N 9 .   ? -13.192 -22.278 -41.817 1.00 43.02  ? 1102 HOH   A O   1 
HETATM 4821 O  O   . HOH   N 9 .   ? -2.949  -74.179 -20.944 0.32 48.81  ? 1103 HOH   A O   1 
HETATM 4822 O  O   . HOH   N 9 .   ? 0.742   -22.682 -46.807 0.50 39.21  ? 1104 HOH   A O   1 
HETATM 4823 O  O   . HOH   N 9 .   ? -33.721 -47.953 -4.368  1.00 34.32  ? 1105 HOH   A O   1 
HETATM 4824 O  O   . HOH   N 9 .   ? -34.955 -21.256 -24.050 1.00 47.32  ? 1106 HOH   A O   1 
HETATM 4825 O  O   . HOH   N 9 .   ? -32.784 -52.293 -27.355 1.00 42.47  ? 1107 HOH   A O   1 
HETATM 4826 O  O   . HOH   N 9 .   ? -22.062 -10.296 -9.725  1.00 55.76  ? 1108 HOH   A O   1 
HETATM 4827 O  O   . HOH   N 9 .   ? -7.646  -49.393 0.610   1.00 50.23  ? 1109 HOH   A O   1 
HETATM 4828 O  O   . HOH   N 9 .   ? -20.121 -9.876  -33.161 1.00 44.99  ? 1110 HOH   A O   1 
HETATM 4829 O  O   . HOH   N 9 .   ? -15.027 -54.907 -39.485 1.00 41.30  ? 1111 HOH   A O   1 
HETATM 4830 O  O   . HOH   N 9 .   ? -4.302  -54.864 -11.910 1.00 45.67  ? 1112 HOH   A O   1 
HETATM 4831 O  O   . HOH   N 9 .   ? 5.919   -45.072 -36.109 1.00 45.24  ? 1113 HOH   A O   1 
HETATM 4832 O  O   . HOH   N 9 .   ? -32.473 -60.923 -18.969 1.00 43.76  ? 1114 HOH   A O   1 
HETATM 4833 O  O   . HOH   N 9 .   ? -3.991  -56.287 -35.834 1.00 61.59  ? 1115 HOH   A O   1 
HETATM 4834 O  O   . HOH   N 9 .   ? -7.172  -20.601 -27.382 1.00 40.29  ? 1116 HOH   A O   1 
HETATM 4835 O  O   . HOH   N 9 .   ? 11.319  -34.582 -33.404 1.00 40.31  ? 1117 HOH   A O   1 
HETATM 4836 O  O   . HOH   N 9 .   ? -16.559 -12.046 -29.722 1.00 50.95  ? 1118 HOH   A O   1 
HETATM 4837 O  O   . HOH   N 9 .   ? -22.507 -54.079 -46.769 1.00 44.28  ? 1119 HOH   A O   1 
HETATM 4838 O  O   . HOH   N 9 .   ? -11.554 -12.366 -9.504  1.00 56.28  ? 1120 HOH   A O   1 
HETATM 4839 O  O   . HOH   N 9 .   ? -20.848 -47.657 -10.134 1.00 51.87  ? 1121 HOH   A O   1 
HETATM 4840 O  O   . HOH   N 9 .   ? 2.943   -51.671 -26.924 0.50 31.71  ? 1122 HOH   A O   1 
HETATM 4841 O  O   . HOH   N 9 .   ? -9.898  -64.861 -33.197 1.00 52.30  ? 1123 HOH   A O   1 
HETATM 4842 O  O   . HOH   N 9 .   ? -13.733 -49.729 -30.113 1.00 45.22  ? 1124 HOH   A O   1 
HETATM 4843 O  O   . HOH   N 9 .   ? -42.459 -63.419 -5.204  1.00 45.37  ? 1125 HOH   A O   1 
HETATM 4844 O  O   . HOH   N 9 .   ? 2.761   -64.891 -20.899 1.00 24.57  ? 1126 HOH   A O   1 
HETATM 4845 O  O   . HOH   N 9 .   ? -21.821 -41.789 -1.795  0.50 54.00  ? 1127 HOH   A O   1 
HETATM 4846 O  O   . HOH   N 9 .   ? -9.069  -37.372 -19.984 1.00 49.56  ? 1128 HOH   A O   1 
HETATM 4847 O  O   . HOH   N 9 .   ? -4.384  -65.749 -15.190 1.00 34.75  ? 1129 HOH   A O   1 
HETATM 4848 O  O   . HOH   N 9 .   ? -15.528 -22.222 -19.262 1.00 42.80  ? 1130 HOH   A O   1 
HETATM 4849 O  O   . HOH   N 9 .   ? -29.337 -56.749 -36.466 1.00 51.56  ? 1131 HOH   A O   1 
HETATM 4850 O  O   . HOH   N 9 .   ? 0.078   -33.154 -28.181 1.00 26.72  ? 1132 HOH   A O   1 
HETATM 4851 O  O   . HOH   N 9 .   ? 10.513  -38.818 -29.920 1.00 49.32  ? 1133 HOH   A O   1 
HETATM 4852 O  O   . HOH   N 9 .   ? -6.358  -12.276 -22.344 1.00 63.91  ? 1134 HOH   A O   1 
HETATM 4853 O  O   . HOH   N 9 .   ? -13.874 -45.324 -3.815  1.00 60.43  ? 1135 HOH   A O   1 
HETATM 4854 O  O   . HOH   N 9 .   ? -4.315  -54.015 -28.095 1.00 25.68  ? 1136 HOH   A O   1 
HETATM 4855 O  O   . HOH   N 9 .   ? -24.231 -69.906 -27.678 1.00 43.21  ? 1137 HOH   A O   1 
HETATM 4856 O  O   . HOH   N 9 .   ? -25.216 -21.135 -8.123  1.00 58.33  ? 1138 HOH   A O   1 
HETATM 4857 O  O   . HOH   N 9 .   ? 4.619   -16.757 -21.989 1.00 54.03  ? 1139 HOH   A O   1 
HETATM 4858 O  O   . HOH   N 9 .   ? -30.007 -50.771 -27.268 1.00 44.36  ? 1140 HOH   A O   1 
HETATM 4859 O  O   . HOH   N 9 .   ? -23.053 -65.752 -38.893 1.00 48.37  ? 1141 HOH   A O   1 
HETATM 4860 O  O   . HOH   N 9 .   ? -40.364 -61.624 -11.344 1.00 30.04  ? 1142 HOH   A O   1 
HETATM 4861 O  O   . HOH   N 9 .   ? 5.445   -30.136 -21.905 1.00 34.31  ? 1143 HOH   A O   1 
HETATM 4862 O  O   . HOH   N 9 .   ? -21.755 -49.954 -34.981 1.00 42.98  ? 1144 HOH   A O   1 
HETATM 4863 O  O   . HOH   N 9 .   ? -27.013 -66.207 -40.081 1.00 42.57  ? 1145 HOH   A O   1 
HETATM 4864 O  O   . HOH   N 9 .   ? -17.402 -32.740 -42.599 0.50 61.34  ? 1146 HOH   A O   1 
HETATM 4865 O  O   . HOH   N 9 .   ? 1.285   -32.661 -39.089 1.00 27.07  ? 1147 HOH   A O   1 
HETATM 4866 O  O   . HOH   N 9 .   ? -28.248 -18.634 -35.191 1.00 44.13  ? 1148 HOH   A O   1 
HETATM 4867 O  O   . HOH   N 9 .   ? -28.760 -70.065 -14.008 1.00 52.62  ? 1149 HOH   A O   1 
HETATM 4868 O  O   . HOH   N 9 .   ? 5.527   -20.185 -43.470 1.00 49.99  ? 1150 HOH   A O   1 
HETATM 4869 O  O   . HOH   N 9 .   ? 7.832   -43.153 -36.594 1.00 48.42  ? 1151 HOH   A O   1 
HETATM 4870 O  O   . HOH   N 9 .   ? -8.045  -43.303 -43.025 1.00 46.97  ? 1152 HOH   A O   1 
HETATM 4871 O  O   . HOH   N 9 .   ? -2.539  -49.458 -39.745 1.00 43.03  ? 1153 HOH   A O   1 
HETATM 4872 O  O   . HOH   N 9 .   ? -12.843 -43.137 -39.100 1.00 36.96  ? 1154 HOH   A O   1 
HETATM 4873 O  O   . HOH   N 9 .   ? -36.941 -50.657 -5.294  1.00 33.75  ? 1155 HOH   A O   1 
HETATM 4874 O  O   . HOH   N 9 .   ? -0.183  -64.160 -20.501 0.32 19.48  ? 1156 HOH   A O   1 
HETATM 4875 O  O   . HOH   N 9 .   ? -9.040  -59.371 -13.311 1.00 24.35  ? 1157 HOH   A O   1 
HETATM 4876 O  O   . HOH   N 9 .   ? -35.161 -50.540 -12.938 1.00 42.38  ? 1158 HOH   A O   1 
HETATM 4877 O  O   . HOH   N 9 .   ? -20.818 -29.569 -25.116 1.00 40.62  ? 1159 HOH   A O   1 
HETATM 4878 O  O   . HOH   N 9 .   ? -3.969  -57.644 -9.784  0.38 36.94  ? 1160 HOH   A O   1 
HETATM 4879 O  O   . HOH   N 9 .   ? -12.469 -58.504 -0.000  0.50 23.77  ? 1161 HOH   A O   1 
HETATM 4880 O  O   . HOH   N 9 .   ? -17.527 -62.450 -44.964 1.00 51.67  ? 1162 HOH   A O   1 
HETATM 4881 O  O   . HOH   N 9 .   ? -29.286 -63.895 -34.626 1.00 58.37  ? 1163 HOH   A O   1 
HETATM 4882 O  O   . HOH   N 9 .   ? -38.398 -67.944 -8.332  1.00 40.37  ? 1164 HOH   A O   1 
HETATM 4883 O  O   . HOH   N 9 .   ? -3.829  -61.878 -15.528 1.00 28.89  ? 1165 HOH   A O   1 
HETATM 4884 O  O   . HOH   N 9 .   ? 10.814  -40.743 -37.914 1.00 46.31  ? 1166 HOH   A O   1 
HETATM 4885 O  O   . HOH   N 9 .   ? -2.544  -55.868 -31.251 1.00 42.55  ? 1167 HOH   A O   1 
HETATM 4886 O  O   . HOH   N 9 .   ? -26.834 -25.956 -33.495 1.00 30.44  ? 1168 HOH   A O   1 
HETATM 4887 O  O   . HOH   N 9 .   ? -10.943 -62.683 -18.783 1.00 18.29  ? 1169 HOH   A O   1 
HETATM 4888 O  O   . HOH   N 9 .   ? -14.701 -64.336 -0.504  1.00 24.71  ? 1170 HOH   A O   1 
HETATM 4889 O  O   . HOH   N 9 .   ? 9.950   -25.858 -32.819 1.00 49.65  ? 1171 HOH   A O   1 
HETATM 4890 O  O   . HOH   N 9 .   ? -19.405 -20.998 -40.798 1.00 36.57  ? 1172 HOH   A O   1 
HETATM 4891 O  O   . HOH   N 9 .   ? -26.343 -50.952 -3.510  0.50 42.33  ? 1173 HOH   A O   1 
HETATM 4892 O  O   . HOH   N 9 .   ? -32.603 -49.299 -18.924 1.00 48.90  ? 1174 HOH   A O   1 
HETATM 4893 O  O   . HOH   N 9 .   ? -40.635 -58.019 -6.322  1.00 52.36  ? 1175 HOH   A O   1 
HETATM 4894 O  O   . HOH   N 9 .   ? -31.894 -57.692 -21.711 1.00 33.85  ? 1176 HOH   A O   1 
HETATM 4895 O  O   . HOH   N 9 .   ? 2.472   -44.654 -41.472 1.00 48.62  ? 1177 HOH   A O   1 
HETATM 4896 O  O   . HOH   N 9 .   ? -19.820 -27.741 -40.266 1.00 31.26  ? 1178 HOH   A O   1 
HETATM 4897 O  O   . HOH   N 9 .   ? -8.875  -64.364 -31.021 1.00 46.15  ? 1179 HOH   A O   1 
HETATM 4898 O  O   . HOH   N 9 .   ? -3.834  -38.078 -45.659 1.00 56.11  ? 1180 HOH   A O   1 
HETATM 4899 O  O   . HOH   N 9 .   ? -18.022 -62.469 -2.998  1.00 23.38  ? 1181 HOH   A O   1 
HETATM 4900 O  O   . HOH   N 9 .   ? -7.412  -47.624 -18.245 1.00 31.88  ? 1182 HOH   A O   1 
HETATM 4901 O  O   . HOH   N 9 .   ? 10.418  -30.237 -34.540 1.00 42.71  ? 1183 HOH   A O   1 
HETATM 4902 O  O   . HOH   N 9 .   ? -0.931  -11.306 -30.553 1.00 48.50  ? 1184 HOH   A O   1 
HETATM 4903 O  O   . HOH   N 9 .   ? -8.397  -65.115 -7.004  1.00 28.39  ? 1185 HOH   A O   1 
HETATM 4904 O  O   . HOH   N 9 .   ? -13.649 -13.188 -27.569 1.00 48.15  ? 1186 HOH   A O   1 
HETATM 4905 O  O   . HOH   N 9 .   ? -4.710  -62.677 -4.630  1.00 39.86  ? 1187 HOH   A O   1 
HETATM 4906 O  O   . HOH   N 9 .   ? -3.458  -20.422 -23.738 1.00 36.34  ? 1188 HOH   A O   1 
HETATM 4907 O  O   . HOH   N 9 .   ? -29.736 -34.119 -28.999 1.00 56.00  ? 1189 HOH   A O   1 
HETATM 4908 O  O   . HOH   N 9 .   ? -11.779 -47.696 -43.293 1.00 58.78  ? 1190 HOH   A O   1 
HETATM 4909 O  O   . HOH   N 9 .   ? 6.050   -31.531 -19.668 1.00 39.36  ? 1191 HOH   A O   1 
HETATM 4910 O  O   . HOH   N 9 .   ? -0.057  -31.428 -23.390 1.00 31.04  ? 1192 HOH   A O   1 
HETATM 4911 O  O   . HOH   N 9 .   ? -32.852 -63.920 -15.112 1.00 27.05  ? 1193 HOH   A O   1 
HETATM 4912 O  O   . HOH   N 9 .   ? 2.693   -39.792 -27.239 1.00 32.79  ? 1194 HOH   A O   1 
HETATM 4913 O  O   . HOH   N 9 .   ? -29.304 -18.148 -21.028 1.00 47.72  ? 1195 HOH   A O   1 
HETATM 4914 O  O   . HOH   N 9 .   ? -20.970 -65.858 -40.994 1.00 40.57  ? 1196 HOH   A O   1 
HETATM 4915 O  O   . HOH   N 9 .   ? -16.747 -32.586 -18.454 1.00 49.20  ? 1197 HOH   A O   1 
HETATM 4916 O  O   . HOH   N 9 .   ? -15.090 -21.659 -16.623 0.50 39.83  ? 1198 HOH   A O   1 
HETATM 4917 O  O   . HOH   N 9 .   ? -38.858 -61.191 -4.265  1.00 40.36  ? 1199 HOH   A O   1 
HETATM 4918 O  O   . HOH   N 9 .   ? -9.138  -26.745 -44.853 1.00 37.81  ? 1200 HOH   A O   1 
HETATM 4919 O  O   . HOH   N 9 .   ? -5.822  -59.482 -12.279 1.00 40.05  ? 1201 HOH   A O   1 
HETATM 4920 O  O   . HOH   N 9 .   ? 8.431   -44.490 -29.578 0.50 41.54  ? 1202 HOH   A O   1 
HETATM 4921 O  O   . HOH   N 9 .   ? -30.340 -57.371 -34.346 1.00 37.52  ? 1203 HOH   A O   1 
HETATM 4922 O  O   . HOH   N 9 .   ? -15.100 -35.227 -29.210 1.00 23.69  ? 1204 HOH   A O   1 
HETATM 4923 O  O   . HOH   N 9 .   ? -13.031 -53.990 -40.766 1.00 54.30  ? 1205 HOH   A O   1 
HETATM 4924 O  O   . HOH   N 9 .   ? -1.669  -41.933 -21.495 1.00 56.73  ? 1206 HOH   A O   1 
HETATM 4925 O  O   . HOH   N 9 .   ? -28.500 -50.300 0.161   1.00 31.96  ? 1207 HOH   A O   1 
HETATM 4926 O  O   . HOH   N 9 .   ? -35.562 -67.007 -0.646  1.00 38.34  ? 1208 HOH   A O   1 
HETATM 4927 O  O   . HOH   N 9 .   ? 5.764   -32.950 -38.073 1.00 41.41  ? 1209 HOH   A O   1 
HETATM 4928 O  O   . HOH   N 9 .   ? -9.510  -40.082 -39.899 1.00 46.93  ? 1210 HOH   A O   1 
HETATM 4929 O  O   . HOH   N 9 .   ? -41.318 -58.504 -9.856  0.50 30.90  ? 1211 HOH   A O   1 
HETATM 4930 O  O   . HOH   N 9 .   ? -27.560 -52.912 -42.088 1.00 49.17  ? 1212 HOH   A O   1 
HETATM 4931 O  O   . HOH   N 9 .   ? -38.943 -57.525 -20.410 1.00 43.81  ? 1213 HOH   A O   1 
HETATM 4932 O  O   . HOH   N 9 .   ? -22.690 -66.195 -23.711 1.00 36.84  ? 1214 HOH   A O   1 
HETATM 4933 O  O   . HOH   N 9 .   ? -11.030 -48.731 -39.256 1.00 27.37  ? 1215 HOH   A O   1 
HETATM 4934 O  O   . HOH   N 9 .   ? -3.846  -75.335 -24.266 0.50 38.80  ? 1216 HOH   A O   1 
HETATM 4935 O  O   . HOH   N 9 .   ? 6.572   -35.571 -44.184 1.00 44.53  ? 1217 HOH   A O   1 
HETATM 4936 O  O   . HOH   N 9 .   ? -14.037 -50.102 -32.263 1.00 32.60  ? 1218 HOH   A O   1 
HETATM 4937 O  O   . HOH   N 9 .   ? 0.026   -55.672 -32.998 1.00 56.15  ? 1219 HOH   A O   1 
HETATM 4938 O  O   . HOH   N 9 .   ? -23.681 -46.849 -36.722 1.00 51.56  ? 1220 HOH   A O   1 
HETATM 4939 O  O   . HOH   N 9 .   ? -26.497 -71.633 -3.481  1.00 35.95  ? 1221 HOH   A O   1 
HETATM 4940 O  O   . HOH   N 9 .   ? -22.500 -51.322 -9.190  1.00 28.65  ? 1222 HOH   A O   1 
HETATM 4941 O  O   . HOH   N 9 .   ? -38.511 -61.350 -14.273 1.00 36.16  ? 1223 HOH   A O   1 
HETATM 4942 O  O   . HOH   N 9 .   ? -19.903 -76.561 -14.216 1.00 59.37  ? 1224 HOH   A O   1 
HETATM 4943 O  O   . HOH   N 9 .   ? -21.712 -66.476 -4.395  1.00 42.07  ? 1225 HOH   A O   1 
HETATM 4944 O  O   . HOH   N 9 .   ? 3.366   -37.992 -44.470 1.00 47.49  ? 1226 HOH   A O   1 
HETATM 4945 O  O   . HOH   N 9 .   ? 0.423   -23.679 -17.287 1.00 61.68  ? 1227 HOH   A O   1 
HETATM 4946 O  O   . HOH   N 9 .   ? -5.329  -49.008 -28.877 1.00 24.92  ? 1228 HOH   A O   1 
HETATM 4947 O  O   . HOH   N 9 .   ? -15.183 -17.548 -36.434 1.00 40.88  ? 1229 HOH   A O   1 
HETATM 4948 O  O   . HOH   N 9 .   ? -18.826 -65.490 -7.209  1.00 20.49  ? 1230 HOH   A O   1 
HETATM 4949 O  O   . HOH   N 9 .   ? -5.415  -60.596 -0.803  1.00 32.44  ? 1231 HOH   A O   1 
HETATM 4950 O  O   . HOH   N 9 .   ? -15.140 -20.308 -21.980 1.00 50.77  ? 1232 HOH   A O   1 
HETATM 4951 O  O   . HOH   N 9 .   ? 10.454  -27.153 -29.450 1.00 46.39  ? 1233 HOH   A O   1 
HETATM 4952 O  O   . HOH   N 9 .   ? -16.552 -67.080 -20.747 1.00 37.85  ? 1234 HOH   A O   1 
HETATM 4953 O  O   . HOH   N 9 .   ? -18.254 -76.640 -16.195 1.00 58.27  ? 1235 HOH   A O   1 
HETATM 4954 O  O   . HOH   N 9 .   ? -5.588  -33.217 -17.872 1.00 42.80  ? 1236 HOH   A O   1 
HETATM 4955 O  O   . HOH   N 9 .   ? -7.109  -50.152 -6.711  1.00 47.70  ? 1237 HOH   A O   1 
HETATM 4956 O  O   . HOH   N 9 .   ? -9.622  -21.681 -27.447 1.00 35.12  ? 1238 HOH   A O   1 
HETATM 4957 O  O   . HOH   N 9 .   ? -12.440 -37.294 -39.810 1.00 29.39  ? 1239 HOH   A O   1 
HETATM 4958 O  O   . HOH   N 9 .   ? -24.842 -14.716 -4.938  1.00 52.84  ? 1240 HOH   A O   1 
HETATM 4959 O  O   . HOH   N 9 .   ? -19.423 -17.415 -11.531 1.00 49.56  ? 1241 HOH   A O   1 
HETATM 4960 O  O   . HOH   N 9 .   ? -23.213 -27.926 -24.876 1.00 42.25  ? 1242 HOH   A O   1 
HETATM 4961 O  O   . HOH   N 9 .   ? -13.720 -74.717 -14.230 1.00 45.79  ? 1243 HOH   A O   1 
HETATM 4962 O  O   . HOH   N 9 .   ? -22.294 -74.627 -11.584 1.00 31.65  ? 1244 HOH   A O   1 
HETATM 4963 O  O   . HOH   N 9 .   ? -29.882 -59.923 -19.663 1.00 36.45  ? 1245 HOH   A O   1 
HETATM 4964 O  O   . HOH   N 9 .   ? -40.011 -64.318 -19.821 1.00 58.55  ? 1246 HOH   A O   1 
HETATM 4965 O  O   . HOH   N 9 .   ? -36.243 -58.711 -20.913 1.00 47.64  ? 1247 HOH   A O   1 
HETATM 4966 O  O   . HOH   N 9 .   ? -33.736 -57.915 -19.669 1.00 39.64  ? 1248 HOH   A O   1 
HETATM 4967 O  O   . HOH   N 9 .   ? 8.516   -40.675 -32.020 1.00 55.33  ? 1249 HOH   A O   1 
HETATM 4968 O  O   . HOH   N 9 .   ? -19.797 -44.087 -38.146 1.00 54.16  ? 1250 HOH   A O   1 
HETATM 4969 O  O   . HOH   N 9 .   ? -35.340 -59.795 -0.528  1.00 47.05  ? 1251 HOH   A O   1 
HETATM 4970 O  O   . HOH   N 9 .   ? -22.946 -28.030 -19.006 1.00 46.90  ? 1252 HOH   A O   1 
HETATM 4971 O  O   . HOH   N 9 .   ? -34.896 -63.112 0.675   1.00 26.14  ? 1253 HOH   A O   1 
HETATM 4972 O  O   . HOH   N 9 .   ? 7.622   -22.152 -24.961 1.00 42.73  ? 1254 HOH   A O   1 
HETATM 4973 O  O   . HOH   N 9 .   ? -28.964 -46.042 2.627   1.00 45.01  ? 1255 HOH   A O   1 
HETATM 4974 O  O   . HOH   N 9 .   ? -17.048 -52.295 -15.589 1.00 21.02  ? 1256 HOH   A O   1 
HETATM 4975 O  O   . HOH   N 9 .   ? -28.107 -23.427 -26.713 1.00 31.18  ? 1257 HOH   A O   1 
HETATM 4976 O  O   . HOH   N 9 .   ? -23.279 -33.904 -36.977 1.00 31.35  ? 1258 HOH   A O   1 
HETATM 4977 O  O   . HOH   N 9 .   ? -30.186 -61.086 -23.099 1.00 32.14  ? 1259 HOH   A O   1 
HETATM 4978 O  O   . HOH   N 9 .   ? -15.391 -66.394 -33.809 1.00 44.14  ? 1260 HOH   A O   1 
HETATM 4979 O  O   . HOH   N 9 .   ? -19.173 -68.711 -1.859  1.00 45.39  ? 1261 HOH   A O   1 
HETATM 4980 O  O   . HOH   N 9 .   ? -31.263 -71.904 -13.479 1.00 58.95  ? 1262 HOH   A O   1 
HETATM 4981 O  O   . HOH   N 9 .   ? -5.943  -50.597 -18.723 1.00 31.88  ? 1263 HOH   A O   1 
HETATM 4982 O  O   . HOH   N 9 .   ? -32.202 -19.513 -31.005 1.00 45.79  ? 1264 HOH   A O   1 
HETATM 4983 O  O   . HOH   N 9 .   ? -24.244 -70.210 -34.136 1.00 59.22  ? 1265 HOH   A O   1 
HETATM 4984 O  O   . HOH   N 9 .   ? -5.007  -34.597 -21.032 1.00 46.84  ? 1266 HOH   A O   1 
HETATM 4985 O  O   . HOH   N 9 .   ? -13.705 -53.871 -1.536  1.00 26.06  ? 1267 HOH   A O   1 
HETATM 4986 O  O   . HOH   N 9 .   ? -14.992 -71.037 -18.541 1.00 40.83  ? 1268 HOH   A O   1 
HETATM 4987 O  O   . HOH   N 9 .   ? -13.338 -68.865 -6.182  1.00 36.75  ? 1269 HOH   A O   1 
HETATM 4988 O  O   . HOH   N 9 .   ? -17.082 -35.661 -42.243 0.50 31.78  ? 1270 HOH   A O   1 
HETATM 4989 O  O   . HOH   N 9 .   ? 7.207   -49.743 -30.612 1.00 51.94  ? 1271 HOH   A O   1 
HETATM 4990 O  O   . HOH   N 9 .   ? -31.797 -60.347 -15.897 1.00 29.84  ? 1272 HOH   A O   1 
HETATM 4991 O  O   . HOH   N 9 .   ? -23.025 -29.668 -14.867 0.50 50.11  ? 1273 HOH   A O   1 
HETATM 4992 O  O   . HOH   N 9 .   ? -28.001 -47.489 0.046   1.00 45.93  ? 1274 HOH   A O   1 
HETATM 4993 O  O   . HOH   N 9 .   ? -10.604 -41.841 -38.102 1.00 39.81  ? 1275 HOH   A O   1 
HETATM 4994 O  O   . HOH   N 9 .   ? -21.036 -19.878 -39.207 1.00 57.45  ? 1276 HOH   A O   1 
HETATM 4995 O  O   . HOH   N 9 .   ? 3.986   -26.979 -29.895 1.00 36.18  ? 1277 HOH   A O   1 
HETATM 4996 O  O   . HOH   N 9 .   ? 5.715   -38.951 -24.562 1.00 42.88  ? 1278 HOH   A O   1 
HETATM 4997 O  O   . HOH   N 9 .   ? -22.190 -31.716 -39.926 1.00 38.09  ? 1279 HOH   A O   1 
HETATM 4998 O  O   . HOH   N 9 .   ? -19.121 -70.024 -8.204  1.00 25.67  ? 1280 HOH   A O   1 
HETATM 4999 O  O   . HOH   N 9 .   ? -15.236 -48.899 -18.868 1.00 32.00  ? 1281 HOH   A O   1 
HETATM 5000 O  O   . HOH   N 9 .   ? -20.646 -66.402 -1.307  1.00 33.29  ? 1282 HOH   A O   1 
HETATM 5001 O  O   . HOH   N 9 .   ? -34.770 -29.032 -30.405 1.00 43.19  ? 1283 HOH   A O   1 
HETATM 5002 O  O   . HOH   N 9 .   ? -33.830 -47.613 -15.731 1.00 55.68  ? 1284 HOH   A O   1 
HETATM 5003 O  O   . HOH   N 9 .   ? -28.713 -68.185 -29.854 1.00 56.82  ? 1285 HOH   A O   1 
HETATM 5004 O  O   . HOH   N 9 .   ? -3.146  -55.423 -18.125 1.00 28.40  ? 1286 HOH   A O   1 
HETATM 5005 O  O   . HOH   N 9 .   ? -35.977 -57.714 -31.035 1.00 60.05  ? 1287 HOH   A O   1 
HETATM 5006 O  O   . HOH   N 9 .   ? -17.325 -29.299 -41.133 1.00 56.07  ? 1288 HOH   A O   1 
HETATM 5007 O  O   . HOH   N 9 .   ? -39.679 -55.685 -6.192  1.00 42.33  ? 1289 HOH   A O   1 
HETATM 5008 O  O   . HOH   N 9 .   ? 1.165   -41.867 -24.645 1.00 39.98  ? 1290 HOH   A O   1 
HETATM 5009 O  O   . HOH   N 9 .   ? 3.958   -29.124 -44.745 1.00 41.16  ? 1291 HOH   A O   1 
HETATM 5010 O  O   . HOH   N 9 .   ? -27.414 -26.972 -35.981 1.00 34.71  ? 1292 HOH   A O   1 
HETATM 5011 O  O   . HOH   N 9 .   ? -27.522 -16.104 -20.071 1.00 48.79  ? 1293 HOH   A O   1 
HETATM 5012 O  O   . HOH   N 9 .   ? -14.836 -68.816 -19.680 1.00 39.35  ? 1294 HOH   A O   1 
HETATM 5013 O  O   . HOH   N 9 .   ? 8.696   -24.320 -36.348 1.00 61.32  ? 1295 HOH   A O   1 
HETATM 5014 O  O   . HOH   N 9 .   ? -10.403 -39.505 -21.738 1.00 52.29  ? 1296 HOH   A O   1 
HETATM 5015 O  O   . HOH   N 9 .   ? -20.583 -67.728 -25.315 1.00 28.05  ? 1297 HOH   A O   1 
HETATM 5016 O  O   . HOH   N 9 .   ? -26.624 -31.039 -23.503 1.00 52.78  ? 1298 HOH   A O   1 
HETATM 5017 O  O   . HOH   N 9 .   ? -39.895 -54.852 -14.846 1.00 41.29  ? 1299 HOH   A O   1 
HETATM 5018 O  O   . HOH   N 9 .   ? -5.989  -49.451 -21.295 1.00 27.61  ? 1300 HOH   A O   1 
HETATM 5019 O  O   . HOH   N 9 .   ? -14.172 -52.558 -5.897  1.00 23.53  ? 1301 HOH   A O   1 
HETATM 5020 O  O   . HOH   N 9 .   ? -29.407 -51.090 -30.044 1.00 57.06  ? 1302 HOH   A O   1 
HETATM 5021 O  O   . HOH   N 9 .   ? -35.895 -54.386 -3.289  1.00 30.73  ? 1303 HOH   A O   1 
HETATM 5022 O  O   . HOH   N 9 .   ? -25.074 -53.746 -1.913  1.00 26.33  ? 1304 HOH   A O   1 
HETATM 5023 O  O   . HOH   N 9 .   ? -18.283 -69.604 -24.544 1.00 39.84  ? 1305 HOH   A O   1 
HETATM 5024 O  O   . HOH   N 9 .   ? -4.842  -56.637 -31.657 1.00 27.76  ? 1306 HOH   A O   1 
HETATM 5025 O  O   . HOH   N 9 .   ? -38.866 -55.368 -19.102 1.00 42.68  ? 1307 HOH   A O   1 
HETATM 5026 O  O   . HOH   N 9 .   ? -34.835 -59.883 -29.559 1.00 55.38  ? 1308 HOH   A O   1 
HETATM 5027 O  O   . HOH   N 9 .   ? -23.297 -50.277 -42.344 1.00 41.22  ? 1309 HOH   A O   1 
HETATM 5028 O  O   . HOH   N 9 .   ? -24.161 -58.521 -46.642 1.00 45.15  ? 1310 HOH   A O   1 
HETATM 5029 O  O   . HOH   N 9 .   ? -0.517  -35.896 -28.395 1.00 32.50  ? 1311 HOH   A O   1 
HETATM 5030 O  O   . HOH   N 9 .   ? -8.738  -17.365 -39.562 1.00 44.75  ? 1312 HOH   A O   1 
HETATM 5031 O  O   . HOH   N 9 .   ? -20.221 -46.604 -25.531 1.00 34.90  ? 1313 HOH   A O   1 
HETATM 5032 O  O   . HOH   N 9 .   ? -14.265 -56.794 -1.494  1.00 21.62  ? 1314 HOH   A O   1 
HETATM 5033 O  O   . HOH   N 9 .   ? -2.564  -58.350 -27.447 1.00 27.07  ? 1315 HOH   A O   1 
HETATM 5034 O  O   . HOH   N 9 .   ? -21.006 -32.130 -29.597 1.00 30.40  ? 1316 HOH   A O   1 
HETATM 5035 O  O   . HOH   N 9 .   ? -16.046 -27.772 -46.200 1.00 55.94  ? 1317 HOH   A O   1 
HETATM 5036 O  O   . HOH   N 9 .   ? 3.702   -43.366 -43.427 1.00 49.66  ? 1318 HOH   A O   1 
HETATM 5037 O  O   . HOH   N 9 .   ? -5.378  -58.732 -30.034 1.00 35.99  ? 1319 HOH   A O   1 
HETATM 5038 O  O   . HOH   N 9 .   ? -12.461 -67.406 -29.575 1.00 36.45  ? 1320 HOH   A O   1 
HETATM 5039 O  O   . HOH   N 9 .   ? -17.617 -66.585 -36.324 1.00 43.44  ? 1321 HOH   A O   1 
HETATM 5040 O  O   . HOH   N 9 .   ? 1.154   -38.782 -21.696 1.00 51.34  ? 1322 HOH   A O   1 
HETATM 5041 O  O   . HOH   N 9 .   ? -8.895  -27.968 -46.855 1.00 55.61  ? 1323 HOH   A O   1 
HETATM 5042 O  O   . HOH   N 9 .   ? -4.294  -23.509 -25.631 1.00 37.64  ? 1324 HOH   A O   1 
HETATM 5043 O  O   . HOH   N 9 .   ? -33.992 -70.698 -18.175 1.00 40.37  ? 1325 HOH   A O   1 
HETATM 5044 O  O   . HOH   N 9 .   ? -4.194  -57.368 -13.483 1.00 42.40  ? 1326 HOH   A O   1 
HETATM 5045 O  O   . HOH   N 9 .   ? -4.055  -15.585 -21.085 1.00 50.45  ? 1327 HOH   A O   1 
HETATM 5046 O  O   . HOH   N 9 .   ? -15.540 -55.558 -43.567 1.00 48.79  ? 1328 HOH   A O   1 
HETATM 5047 O  O   . HOH   N 9 .   ? -39.819 -64.391 -2.169  1.00 49.15  ? 1329 HOH   A O   1 
HETATM 5048 O  O   . HOH   N 9 .   ? -10.113 -25.664 -12.871 1.00 50.63  ? 1330 HOH   A O   1 
HETATM 5049 O  O   . HOH   N 9 .   ? -35.647 -59.128 -27.313 1.00 46.25  ? 1331 HOH   A O   1 
HETATM 5050 O  O   . HOH   N 9 .   ? -17.642 -42.211 -37.206 1.00 42.35  ? 1332 HOH   A O   1 
HETATM 5051 O  O   . HOH   N 9 .   ? -2.378  -40.069 -45.968 1.00 43.19  ? 1333 HOH   A O   1 
HETATM 5052 O  O   . HOH   N 9 .   ? -20.273 -38.419 -36.892 1.00 32.71  ? 1334 HOH   A O   1 
HETATM 5053 O  O   . HOH   N 9 .   ? -12.142 -40.127 -39.715 1.00 57.68  ? 1335 HOH   A O   1 
HETATM 5054 O  O   . HOH   N 9 .   ? -17.280 -58.074 -43.710 1.00 35.79  ? 1336 HOH   A O   1 
HETATM 5055 O  O   . HOH   N 9 .   ? -27.267 -57.373 -40.088 1.00 44.18  ? 1337 HOH   A O   1 
HETATM 5056 O  O   . HOH   N 9 .   ? -24.465 -69.306 -38.187 1.00 52.20  ? 1338 HOH   A O   1 
HETATM 5057 O  O   . HOH   N 9 .   ? 3.319   -31.753 -37.568 1.00 26.62  ? 1339 HOH   A O   1 
HETATM 5058 O  O   . HOH   N 9 .   ? -7.805  -62.439 -33.599 1.00 43.71  ? 1340 HOH   A O   1 
HETATM 5059 O  O   . HOH   N 9 .   ? -12.098 -41.722 -20.337 0.50 52.94  ? 1341 HOH   A O   1 
HETATM 5060 O  O   . HOH   N 9 .   ? 9.825   -38.233 -39.634 1.00 43.15  ? 1342 HOH   A O   1 
HETATM 5061 O  O   . HOH   N 9 .   ? -37.643 -52.828 -13.034 1.00 32.45  ? 1343 HOH   A O   1 
HETATM 5062 O  O   . HOH   N 9 .   ? -28.157 -17.200 -32.675 1.00 37.68  ? 1344 HOH   A O   1 
HETATM 5063 O  O   . HOH   N 9 .   ? -14.816 -54.525 -4.093  1.00 22.22  ? 1345 HOH   A O   1 
HETATM 5064 O  O   . HOH   N 9 .   ? -13.580 -11.946 -32.989 1.00 53.74  ? 1346 HOH   A O   1 
HETATM 5065 O  O   . HOH   N 9 .   ? -29.955 -61.818 -33.130 1.00 45.71  ? 1347 HOH   A O   1 
HETATM 5066 O  O   . HOH   N 9 .   ? -31.249 -45.554 -15.606 1.00 51.33  ? 1348 HOH   A O   1 
HETATM 5067 O  O   . HOH   N 9 .   ? -5.950  -69.385 -7.296  1.00 38.50  ? 1349 HOH   A O   1 
HETATM 5068 O  O   . HOH   N 9 .   ? -6.328  -43.402 -21.589 1.00 48.66  ? 1350 HOH   A O   1 
HETATM 5069 O  O   . HOH   N 9 .   ? -21.400 -42.025 -35.635 1.00 47.75  ? 1351 HOH   A O   1 
HETATM 5070 O  O   . HOH   N 9 .   ? -12.842 -38.161 -22.686 1.00 48.67  ? 1352 HOH   A O   1 
HETATM 5071 O  O   . HOH   N 9 .   ? -3.823  -71.169 -8.913  1.00 39.14  ? 1353 HOH   A O   1 
HETATM 5072 O  O   . HOH   N 9 .   ? -3.796  -56.871 -7.089  1.00 31.39  ? 1354 HOH   A O   1 
HETATM 5073 O  O   . HOH   N 9 .   ? -20.924 -75.986 -5.646  1.00 58.46  ? 1355 HOH   A O   1 
HETATM 5074 O  O   . HOH   N 9 .   ? -24.865 -31.081 -40.059 1.00 53.09  ? 1356 HOH   A O   1 
HETATM 5075 O  O   . HOH   N 9 .   ? -7.166  -57.874 -1.084  1.00 41.28  ? 1357 HOH   A O   1 
HETATM 5076 O  O   . HOH   N 9 .   ? -23.015 -37.922 -37.410 1.00 42.49  ? 1358 HOH   A O   1 
HETATM 5077 O  O   . HOH   N 9 .   ? -3.014  -58.403 -24.631 1.00 22.99  ? 1359 HOH   A O   1 
HETATM 5078 O  O   . HOH   N 9 .   ? -6.483  -37.219 -20.773 1.00 48.54  ? 1360 HOH   A O   1 
HETATM 5079 O  O   . HOH   N 9 .   ? -20.405 -31.740 -26.841 1.00 30.23  ? 1361 HOH   A O   1 
HETATM 5080 O  O   . HOH   N 9 .   ? -22.755 -44.790 -33.356 0.50 42.12  ? 1362 HOH   A O   1 
HETATM 5081 O  O   . HOH   N 9 .   ? -23.037 -75.719 -9.153  1.00 45.46  ? 1363 HOH   A O   1 
HETATM 5082 O  O   . HOH   N 9 .   ? -27.531 -40.736 -5.553  1.00 63.20  ? 1364 HOH   A O   1 
HETATM 5083 O  O   . HOH   N 9 .   ? -13.692 -51.560 -43.237 1.00 55.66  ? 1365 HOH   A O   1 
HETATM 5084 O  O   . HOH   N 9 .   ? -4.475  -53.130 -38.694 1.00 52.77  ? 1366 HOH   A O   1 
HETATM 5085 O  O   . HOH   N 9 .   ? -7.880  -30.270 -46.307 1.00 38.50  ? 1367 HOH   A O   1 
HETATM 5086 O  O   . HOH   N 9 .   ? -23.706 -47.199 -33.495 0.50 39.08  ? 1368 HOH   A O   1 
HETATM 5087 O  O   . HOH   N 9 .   ? -18.842 -49.862 -35.303 1.00 40.33  ? 1369 HOH   A O   1 
HETATM 5088 O  O   . HOH   N 9 .   ? -28.791 -70.335 -22.692 1.00 60.66  ? 1370 HOH   A O   1 
HETATM 5089 O  O   . HOH   N 9 .   ? -37.652 -68.742 -12.448 1.00 45.34  ? 1371 HOH   A O   1 
HETATM 5090 O  O   . HOH   N 9 .   ? -5.717  -59.137 -37.011 1.00 53.27  ? 1372 HOH   A O   1 
HETATM 5091 O  O   . HOH   N 9 .   ? 11.663  -36.832 -19.528 1.00 58.35  ? 1373 HOH   A O   1 
HETATM 5092 O  O   . HOH   N 9 .   ? 13.303  -30.548 -19.857 1.00 45.97  ? 1374 HOH   A O   1 
HETATM 5093 O  O   . HOH   N 9 .   ? -23.132 -21.041 -37.959 1.00 46.14  ? 1375 HOH   A O   1 
HETATM 5094 O  O   . HOH   N 9 .   ? -23.515 -45.638 -8.979  1.00 47.03  ? 1376 HOH   A O   1 
HETATM 5095 O  O   . HOH   N 9 .   ? -0.224  -48.390 -36.537 1.00 32.16  ? 1377 HOH   A O   1 
HETATM 5096 O  O   . HOH   N 9 .   ? 0.703   -31.535 -47.351 1.00 41.30  ? 1378 HOH   A O   1 
HETATM 5097 O  O   . HOH   N 9 .   ? -14.746 -70.559 -3.136  1.00 52.84  ? 1379 HOH   A O   1 
HETATM 5098 O  O   . HOH   N 9 .   ? -8.556  -31.306 -15.523 1.00 48.75  ? 1380 HOH   A O   1 
HETATM 5099 O  O   . HOH   N 9 .   ? -19.232 -64.980 -3.033  1.00 34.39  ? 1381 HOH   A O   1 
HETATM 5100 O  O   . HOH   N 9 .   ? -0.931  -69.619 -17.085 0.32 37.51  ? 1382 HOH   A O   1 
HETATM 5101 O  O   . HOH   N 9 .   ? -28.386 -49.497 -31.790 1.00 47.69  ? 1383 HOH   A O   1 
HETATM 5102 O  O   . HOH   N 9 .   ? -17.657 -71.765 -22.834 1.00 53.30  ? 1384 HOH   A O   1 
HETATM 5103 O  O   . HOH   N 9 .   ? -14.730 -57.659 -41.989 1.00 32.07  ? 1385 HOH   A O   1 
HETATM 5104 O  O   . HOH   N 9 .   ? 1.094   -63.634 -18.094 0.32 33.40  ? 1386 HOH   A O   1 
HETATM 5105 O  O   . HOH   N 9 .   ? -38.433 -28.464 -27.245 1.00 44.62  ? 1387 HOH   A O   1 
HETATM 5106 O  O   . HOH   N 9 .   ? -1.030  -32.663 -25.732 1.00 29.97  ? 1388 HOH   A O   1 
HETATM 5107 O  O   . HOH   N 9 .   ? -20.263 -71.013 -5.767  1.00 40.18  ? 1389 HOH   A O   1 
HETATM 5108 O  O   . HOH   N 9 .   ? -7.526  -51.632 -10.497 1.00 54.18  ? 1390 HOH   A O   1 
HETATM 5109 O  O   . HOH   N 9 .   ? -27.377 -9.256  -30.512 1.00 53.08  ? 1391 HOH   A O   1 
HETATM 5110 O  O   . HOH   N 9 .   ? -9.032  -36.159 -45.005 1.00 61.26  ? 1392 HOH   A O   1 
HETATM 5111 O  O   . HOH   N 9 .   ? -28.720 -63.373 -25.325 1.00 35.83  ? 1393 HOH   A O   1 
HETATM 5112 O  O   . HOH   N 9 .   ? -6.068  -40.151 -45.711 1.00 62.68  ? 1394 HOH   A O   1 
HETATM 5113 O  O   . HOH   N 9 .   ? -4.216  -34.585 -14.621 1.00 49.69  ? 1395 HOH   A O   1 
HETATM 5114 O  O   . HOH   N 9 .   ? -12.221 -44.437 -16.604 1.00 54.26  ? 1396 HOH   A O   1 
HETATM 5115 O  O   . HOH   N 9 .   ? -26.613 -68.219 -27.911 1.00 31.72  ? 1397 HOH   A O   1 
HETATM 5116 O  O   . HOH   N 9 .   ? -13.375 -32.842 -20.672 1.00 40.27  ? 1398 HOH   A O   1 
HETATM 5117 O  O   . HOH   N 9 .   ? -1.850  -59.824 -31.978 1.00 60.52  ? 1399 HOH   A O   1 
HETATM 5118 O  O   . HOH   N 9 .   ? -38.851 -38.257 -26.631 1.00 62.22  ? 1400 HOH   A O   1 
HETATM 5119 O  O   . HOH   N 9 .   ? -11.205 -46.641 3.966   1.00 43.27  ? 1401 HOH   A O   1 
HETATM 5120 O  O   . HOH   N 9 .   ? -35.059 -68.084 -5.580  1.00 45.91  ? 1402 HOH   A O   1 
HETATM 5121 O  O   . HOH   N 9 .   ? 4.424   -62.762 -20.276 1.00 21.95  ? 1403 HOH   A O   1 
HETATM 5122 O  O   . HOH   N 9 .   ? 0.360   -46.060 -37.301 1.00 47.33  ? 1404 HOH   A O   1 
HETATM 5123 O  O   . HOH   N 9 .   ? -9.245  -62.428 -41.900 1.00 60.26  ? 1405 HOH   A O   1 
HETATM 5124 O  O   . HOH   N 9 .   ? -22.955 -63.376 -23.489 1.00 43.74  ? 1406 HOH   A O   1 
HETATM 5125 O  O   . HOH   N 9 .   ? 0.124   -46.092 -42.957 1.00 52.57  ? 1407 HOH   A O   1 
HETATM 5126 O  O   . HOH   N 9 .   ? -10.201 -70.677 -21.322 0.32 54.15  ? 1408 HOH   A O   1 
HETATM 5127 O  O   . HOH   N 9 .   ? -23.214 -37.460 -32.897 1.00 52.73  ? 1409 HOH   A O   1 
HETATM 5128 O  O   . HOH   N 9 .   ? -12.586 -70.348 -22.943 1.00 55.12  ? 1410 HOH   A O   1 
HETATM 5129 O  O   . HOH   N 9 .   ? -35.713 -51.153 -23.255 1.00 54.01  ? 1411 HOH   A O   1 
HETATM 5130 O  O   . HOH   N 9 .   ? -16.376 -49.505 -16.280 1.00 24.91  ? 1412 HOH   A O   1 
HETATM 5131 O  O   . HOH   N 9 .   ? -21.270 -44.073 -42.100 1.00 71.85  ? 1413 HOH   A O   1 
HETATM 5132 O  O   . HOH   N 9 .   ? -40.063 -24.340 -26.742 1.00 48.54  ? 1414 HOH   A O   1 
HETATM 5133 O  O   . HOH   N 9 .   ? -10.711 -34.385 -44.376 1.00 54.22  ? 1415 HOH   A O   1 
HETATM 5134 O  O   . HOH   N 9 .   ? -26.515 -28.229 -43.200 1.00 59.94  ? 1416 HOH   A O   1 
HETATM 5135 O  O   . HOH   N 9 .   ? -10.821 -71.931 -15.498 0.32 23.91  ? 1417 HOH   A O   1 
HETATM 5136 O  O   . HOH   N 9 .   ? -17.790 -47.390 -15.014 1.00 40.55  ? 1418 HOH   A O   1 
HETATM 5137 O  O   . HOH   N 9 .   ? -2.897  -56.038 -28.841 1.00 26.30  ? 1419 HOH   A O   1 
HETATM 5138 O  O   . HOH   N 9 .   ? 3.423   -34.062 -14.360 1.00 59.31  ? 1420 HOH   A O   1 
HETATM 5139 O  O   . HOH   N 9 .   ? -30.254 -34.252 -32.732 1.00 58.90  ? 1421 HOH   A O   1 
HETATM 5140 O  O   . HOH   N 9 .   ? -36.352 -61.150 -20.638 1.00 61.16  ? 1422 HOH   A O   1 
HETATM 5141 O  O   . HOH   N 9 .   ? -34.082 -49.683 -10.422 1.00 44.09  ? 1423 HOH   A O   1 
HETATM 5142 O  O   . HOH   N 9 .   ? 14.976  -33.104 -32.301 0.50 56.40  ? 1424 HOH   A O   1 
HETATM 5143 O  O   . HOH   N 9 .   ? -19.056 -45.695 -9.223  1.00 60.85  ? 1425 HOH   A O   1 
HETATM 5144 O  O   . HOH   N 9 .   ? -13.389 -45.666 -9.894  1.00 69.94  ? 1426 HOH   A O   1 
HETATM 5145 O  O   . HOH   N 9 .   ? -6.991  -61.068 -30.524 1.00 56.61  ? 1427 HOH   A O   1 
HETATM 5146 O  O   . HOH   N 9 .   ? -35.768 -57.821 -3.894  1.00 57.47  ? 1428 HOH   A O   1 
HETATM 5147 O  O   . HOH   N 9 .   ? -31.040 -16.957 -32.291 1.00 48.24  ? 1429 HOH   A O   1 
HETATM 5148 O  O   . HOH   N 9 .   ? 8.656   -43.605 -32.765 1.00 68.41  ? 1430 HOH   A O   1 
HETATM 5149 O  O   . HOH   N 9 .   ? 0.000   -58.504 -16.481 0.50 59.33  ? 1431 HOH   A O   1 
HETATM 5150 O  O   . HOH   N 9 .   ? -29.219 -69.817 -40.073 0.50 35.63  ? 1432 HOH   A O   1 
HETATM 5151 O  O   . HOH   N 9 .   ? -36.746 -65.148 0.089   1.00 43.73  ? 1433 HOH   A O   1 
HETATM 5152 O  O   . HOH   N 9 .   ? -8.365  -68.693 -28.540 1.00 51.81  ? 1434 HOH   A O   1 
HETATM 5153 O  O   . HOH   N 9 .   ? -5.725  -31.482 -48.249 1.00 56.85  ? 1435 HOH   A O   1 
HETATM 5154 O  O   . HOH   N 9 .   ? -9.841  -32.339 -46.412 1.00 58.80  ? 1436 HOH   A O   1 
HETATM 5155 O  O   . HOH   N 9 .   ? -31.986 -13.509 -9.634  1.00 61.86  ? 1437 HOH   A O   1 
HETATM 5156 O  O   . HOH   N 9 .   ? -9.575  -55.906 -41.836 1.00 60.59  ? 1438 HOH   A O   1 
HETATM 5157 O  O   . HOH   N 9 .   ? -25.106 -21.086 -5.088  1.00 61.21  ? 1439 HOH   A O   1 
HETATM 5158 O  O   . HOH   N 9 .   ? -10.881 -17.952 -40.768 1.00 50.42  ? 1440 HOH   A O   1 
HETATM 5159 O  O   . HOH   N 9 .   ? -7.416  -30.248 -13.600 1.00 55.58  ? 1441 HOH   A O   1 
HETATM 5160 O  O   . HOH   N 9 .   ? -27.231 -74.007 -4.634  1.00 43.94  ? 1442 HOH   A O   1 
HETATM 5161 O  O   . HOH   N 9 .   ? -41.372 -24.566 -18.053 1.00 63.44  ? 1443 HOH   A O   1 
HETATM 5162 O  O   . HOH   N 9 .   ? -12.294 -76.107 -26.869 1.00 63.14  ? 1444 HOH   A O   1 
HETATM 5163 O  O   . HOH   N 9 .   ? -9.578  -23.996 -3.759  1.00 67.91  ? 1445 HOH   A O   1 
HETATM 5164 O  O   . HOH   N 9 .   ? -18.021 -28.189 -44.794 1.00 51.48  ? 1446 HOH   A O   1 
HETATM 5165 O  O   . HOH   N 9 .   ? -37.951 -52.664 -4.062  1.00 46.07  ? 1447 HOH   A O   1 
HETATM 5166 O  O   . HOH   N 9 .   ? -15.799 -69.490 -6.000  1.00 26.53  ? 1448 HOH   A O   1 
HETATM 5167 O  O   . HOH   N 9 .   ? -42.846 -66.589 -9.385  1.00 60.26  ? 1449 HOH   A O   1 
HETATM 5168 O  O   . HOH   N 9 .   ? -15.611 -45.320 -10.705 1.00 73.68  ? 1450 HOH   A O   1 
HETATM 5169 O  O   . HOH   N 9 .   ? -19.157 -40.054 -38.676 1.00 44.12  ? 1451 HOH   A O   1 
HETATM 5170 O  O   . HOH   N 9 .   ? 0.000   -58.504 -28.528 0.50 30.45  ? 1452 HOH   A O   1 
HETATM 5171 O  O   . HOH   N 9 .   ? -25.247 -28.202 -20.011 1.00 52.44  ? 1453 HOH   A O   1 
HETATM 5172 O  O   . HOH   N 9 .   ? -3.259  -52.397 -4.320  1.00 69.85  ? 1454 HOH   A O   1 
HETATM 5173 O  O   . HOH   N 9 .   ? -17.009 -39.346 -40.063 1.00 55.45  ? 1455 HOH   A O   1 
HETATM 5174 O  O   . HOH   N 9 .   ? -3.148  -72.992 -6.625  1.00 61.24  ? 1456 HOH   A O   1 
HETATM 5175 O  O   . HOH   N 9 .   ? -34.956 -49.957 -20.977 1.00 62.77  ? 1457 HOH   A O   1 
HETATM 5176 O  O   . HOH   N 9 .   ? -25.925 -20.019 -39.056 1.00 46.77  ? 1458 HOH   A O   1 
HETATM 5177 O  O   . HOH   N 9 .   ? -15.631 -42.113 -38.785 1.00 33.83  ? 1459 HOH   A O   1 
HETATM 5178 O  O   . HOH   N 9 .   ? -25.109 -28.770 -22.737 1.00 52.44  ? 1460 HOH   A O   1 
HETATM 5179 O  O   . HOH   N 9 .   ? -20.100 -59.323 -48.300 1.00 67.61  ? 1461 HOH   A O   1 
HETATM 5180 O  O   . HOH   N 9 .   ? -1.710  -52.111 1.940   1.00 60.72  ? 1462 HOH   A O   1 
HETATM 5181 O  O   . HOH   N 9 .   ? -31.011 -60.133 -34.499 1.00 45.96  ? 1463 HOH   A O   1 
HETATM 5182 O  O   . HOH   N 9 .   ? -15.635 -45.699 -19.515 1.00 53.74  ? 1464 HOH   A O   1 
HETATM 5183 O  O   . HOH   N 9 .   ? -3.016  -61.299 -5.658  1.00 62.04  ? 1465 HOH   A O   1 
HETATM 5184 O  O   . HOH   N 9 .   ? -30.660 -63.430 -36.837 1.00 58.12  ? 1466 HOH   A O   1 
HETATM 5185 O  O   . HOH   N 9 .   ? -24.285 -36.388 -35.271 1.00 45.77  ? 1467 HOH   A O   1 
HETATM 5186 O  O   . HOH   N 9 .   ? -41.470 -56.880 -13.645 1.00 36.53  ? 1468 HOH   A O   1 
HETATM 5187 O  O   . HOH   N 9 .   ? -5.398  -65.566 -31.302 1.00 51.18  ? 1469 HOH   A O   1 
HETATM 5188 O  O   . HOH   N 9 .   ? -9.974  -40.142 -42.470 0.50 49.09  ? 1470 HOH   A O   1 
HETATM 5189 O  O   . HOH   N 9 .   ? 0.409   -71.659 -21.523 0.32 35.56  ? 1471 HOH   A O   1 
HETATM 5190 O  O   . HOH   N 9 .   ? -23.597 -75.591 -14.063 1.00 56.96  ? 1472 HOH   A O   1 
HETATM 5191 O  O   . HOH   N 9 .   ? -14.273 -38.229 -40.877 0.50 47.02  ? 1473 HOH   A O   1 
HETATM 5192 O  O   . HOH   N 9 .   ? -4.026  -49.881 3.211   1.00 69.74  ? 1474 HOH   A O   1 
HETATM 5193 O  O   . HOH   N 9 .   ? -35.889 -48.371 -14.008 1.00 50.39  ? 1475 HOH   A O   1 
HETATM 5194 O  O   . HOH   N 9 .   ? -6.535  -45.289 -17.411 1.00 55.28  ? 1476 HOH   A O   1 
HETATM 5195 O  O   . HOH   N 9 .   ? -29.227 -21.839 -42.778 1.00 48.46  ? 1477 HOH   A O   1 
HETATM 5196 O  O   . HOH   N 9 .   ? -11.015 -38.390 -43.791 0.50 41.78  ? 1478 HOH   A O   1 
HETATM 5197 O  O   . HOH   N 9 .   ? -2.933  -56.849 -33.886 1.00 44.76  ? 1479 HOH   A O   1 
HETATM 5198 O  O   . HOH   N 9 .   ? -18.240 -68.154 -6.386  1.00 24.73  ? 1480 HOH   A O   1 
HETATM 5199 O  O   . HOH   N 9 .   ? -10.075 -28.016 -12.079 1.00 55.03  ? 1481 HOH   A O   1 
HETATM 5200 O  O   . HOH   N 9 .   ? -1.656  -56.006 -6.059  1.00 47.40  ? 1482 HOH   A O   1 
HETATM 5201 O  O   . HOH   N 9 .   ? -4.542  -66.694 -6.167  1.00 58.93  ? 1483 HOH   A O   1 
HETATM 5202 O  O   . HOH   N 9 .   ? -1.278  -55.627 -0.890  1.00 44.11  ? 1484 HOH   A O   1 
HETATM 5203 O  O   . HOH   N 9 .   ? 16.523  -34.096 -26.973 1.00 57.12  ? 1485 HOH   A O   1 
HETATM 5204 O  O   . HOH   N 9 .   ? -16.095 -60.313 -45.371 1.00 57.26  ? 1486 HOH   A O   1 
HETATM 5205 O  O   . HOH   N 9 .   ? -5.559  -64.421 -6.634  1.00 37.27  ? 1487 HOH   A O   1 
HETATM 5206 O  O   . HOH   N 9 .   ? -12.171 -36.304 -43.519 0.50 49.02  ? 1488 HOH   A O   1 
HETATM 5207 O  O   . HOH   N 9 .   ? -19.986 -68.550 -4.326  1.00 29.16  ? 1489 HOH   A O   1 
HETATM 5208 O  O   . HOH   N 9 .   ? -2.863  -59.724 -0.607  1.00 36.58  ? 1490 HOH   A O   1 
HETATM 5209 O  O   . HOH   N 9 .   ? -1.737  -59.865 -3.154  1.00 51.21  ? 1491 HOH   A O   1 
HETATM 5210 O  O   . HOH   N 9 .   ? -4.133  -61.063 -10.437 1.00 53.57  ? 1492 HOH   A O   1 
HETATM 5211 O  O   . HOH   N 9 .   ? -44.303 -68.581 -17.075 1.00 65.94  ? 1493 HOH   A O   1 
HETATM 5212 O  O   . HOH   N 9 .   ? 9.950   -20.903 -26.039 1.00 46.72  ? 1494 HOH   A O   1 
HETATM 5213 O  O   . HOH   N 9 .   ? 12.936  -25.671 -27.329 1.00 55.48  ? 1495 HOH   A O   1 
HETATM 5214 O  O   . HOH   N 9 .   ? -43.058 -60.929 -1.918  1.00 59.94  ? 1496 HOH   A O   1 
HETATM 5215 O  O   . HOH   N 9 .   ? -22.755 -41.483 -44.261 1.00 70.20  ? 1497 HOH   A O   1 
HETATM 5216 O  O   . HOH   N 9 .   ? -4.004  -62.882 -9.186  1.00 52.51  ? 1498 HOH   A O   1 
# 
