data_7I2B
# 
_entry.id   7I2B 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   7I2B         pdb_00007i2b 10.2210/pdb7i2b/pdb 
WWPDB D_1001408226 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-02 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.entry_id                        7I2B 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.recvd_initial_deposition_date   2025-03-06 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.SG_entry                        ? 
_pdbx_database_status.pdb_format_compatible           Y 
_pdbx_database_status.methods_development_category    ? 
# 
_pdbx_contact_author.id                 1 
_pdbx_contact_author.email              fr193@cabm.rutgers.edu 
_pdbx_contact_author.name_first         'Francesc Xavier' 
_pdbx_contact_author.name_last          Ruiz 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-0457-0030 
_pdbx_contact_author.name_mi            ? 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Aschenbrenner, J.C.' 1  ? 
'Saini, M.'           2  ? 
'Chopra, A.'          3  ? 
'Marples, P.G.'       4  ? 
'Balcomb, B.H.'       5  ? 
'Lithgo, R.M.'        6  ? 
'Fearon, D.'          7  ? 
'von Delft, F.'       8  ? 
'Ruiz, F.X.'          9  ? 
'Arnold, E.'          10 ? 
# 
_citation.id                        primary 
_citation.title                     
'Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_volume            ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.year                      ? 
_citation.journal_id_ASTM           ? 
_citation.country                   ? 
_citation.journal_id_ISSN           ? 
_citation.journal_id_CSD            0353 
_citation.book_publisher            ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_DOI      ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.identifier_ORCID 
_citation_author.ordinal 
primary 'Aschenbrenner, J.C.' ? 1  
primary 'Saini, M.'           ? 2  
primary 'Chopra, A.'          ? 3  
primary 'Marples, P.G.'       ? 4  
primary 'Balcomb, B.H.'       ? 5  
primary 'Lithgo, R.M.'        ? 6  
primary 'Fearon, D.'          ? 7  
primary 'von Delft, F.'       ? 8  
primary 'Ruiz, F.X.'          ? 9  
primary 'Arnold, E.'          ? 10 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'NS5 RNA-dependent RNA polymerase'      73890.008 1   ? ? ? ? 
2 non-polymer syn 'ZINC ION'                              65.409    2   ? ? ? ? 
3 non-polymer syn '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'  195.237   1   ? ? ? ? 
4 non-polymer syn 'DIMETHYL SULFOXIDE'                    78.133    3   ? ? ? ? 
5 non-polymer syn 'DI(HYDROXYETHYL)ETHER'                 106.120   2   ? ? ? ? 
6 non-polymer syn 'PHOSPHATE ION'                         94.971    2   ? ? ? ? 
7 non-polymer syn '~{N}-(4-phenylazanylphenyl)ethanamide' 226.274   1   ? ? ? ? 
8 non-polymer syn 'CHLORIDE ION'                          35.453    1   ? ? ? ? 
9 water       nat water                                   18.015    392 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;GPGIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAM
TDTTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAR
EAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENS
LSGVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRP
TPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGD
DCVVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQG
AGWSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPW
MEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_entity_poly.pdbx_seq_one_letter_code_can   
;GPGIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAM
TDTTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAR
EAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENS
LSGVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRP
TPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGD
DCVVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQG
AGWSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPW
MEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'ZINC ION'                              ZN  
3 '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'  MES 
4 'DIMETHYL SULFOXIDE'                    DMS 
5 'DI(HYDROXYETHYL)ETHER'                 PEG 
6 'PHOSPHATE ION'                         PO4 
7 '~{N}-(4-phenylazanylphenyl)ethanamide' B1A 
8 'CHLORIDE ION'                          CL  
9 water                                   HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   PRO n 
1 3   GLY n 
1 4   ILE n 
1 5   GLU n 
1 6   SER n 
1 7   GLU n 
1 8   THR n 
1 9   PRO n 
1 10  ASN n 
1 11  LEU n 
1 12  ASP n 
1 13  ILE n 
1 14  ILE n 
1 15  GLY n 
1 16  LYS n 
1 17  ARG n 
1 18  ILE n 
1 19  GLU n 
1 20  LYS n 
1 21  ILE n 
1 22  LYS n 
1 23  GLN n 
1 24  GLU n 
1 25  HIS n 
1 26  GLU n 
1 27  THR n 
1 28  SER n 
1 29  TRP n 
1 30  HIS n 
1 31  TYR n 
1 32  ASP n 
1 33  GLN n 
1 34  ASP n 
1 35  HIS n 
1 36  PRO n 
1 37  TYR n 
1 38  LYS n 
1 39  THR n 
1 40  TRP n 
1 41  ALA n 
1 42  TYR n 
1 43  HIS n 
1 44  GLY n 
1 45  SER n 
1 46  TYR n 
1 47  GLU n 
1 48  THR n 
1 49  LYS n 
1 50  GLN n 
1 51  THR n 
1 52  GLY n 
1 53  SER n 
1 54  ALA n 
1 55  SER n 
1 56  SER n 
1 57  MET n 
1 58  VAL n 
1 59  ASN n 
1 60  GLY n 
1 61  VAL n 
1 62  VAL n 
1 63  ARG n 
1 64  LEU n 
1 65  LEU n 
1 66  THR n 
1 67  LYS n 
1 68  PRO n 
1 69  TRP n 
1 70  ASP n 
1 71  ILE n 
1 72  ILE n 
1 73  PRO n 
1 74  MET n 
1 75  VAL n 
1 76  THR n 
1 77  GLN n 
1 78  MET n 
1 79  ALA n 
1 80  MET n 
1 81  THR n 
1 82  ASP n 
1 83  THR n 
1 84  THR n 
1 85  PRO n 
1 86  PHE n 
1 87  GLY n 
1 88  GLN n 
1 89  GLN n 
1 90  ARG n 
1 91  VAL n 
1 92  PHE n 
1 93  LYS n 
1 94  GLU n 
1 95  LYS n 
1 96  VAL n 
1 97  ASP n 
1 98  THR n 
1 99  ARG n 
1 100 THR n 
1 101 GLN n 
1 102 GLU n 
1 103 PRO n 
1 104 LYS n 
1 105 GLU n 
1 106 GLY n 
1 107 THR n 
1 108 LYS n 
1 109 LYS n 
1 110 LEU n 
1 111 MET n 
1 112 LYS n 
1 113 ILE n 
1 114 THR n 
1 115 ALA n 
1 116 GLU n 
1 117 TRP n 
1 118 LEU n 
1 119 TRP n 
1 120 LYS n 
1 121 GLU n 
1 122 LEU n 
1 123 GLY n 
1 124 LYS n 
1 125 LYS n 
1 126 LYS n 
1 127 THR n 
1 128 PRO n 
1 129 ARG n 
1 130 MET n 
1 131 CYS n 
1 132 THR n 
1 133 ARG n 
1 134 GLU n 
1 135 GLU n 
1 136 PHE n 
1 137 THR n 
1 138 ARG n 
1 139 LYS n 
1 140 VAL n 
1 141 ARG n 
1 142 SER n 
1 143 ASN n 
1 144 ALA n 
1 145 ALA n 
1 146 LEU n 
1 147 GLY n 
1 148 ALA n 
1 149 ILE n 
1 150 PHE n 
1 151 THR n 
1 152 ASP n 
1 153 GLU n 
1 154 ASN n 
1 155 LYS n 
1 156 TRP n 
1 157 LYS n 
1 158 SER n 
1 159 ALA n 
1 160 ARG n 
1 161 GLU n 
1 162 ALA n 
1 163 VAL n 
1 164 GLU n 
1 165 ASP n 
1 166 SER n 
1 167 GLY n 
1 168 PHE n 
1 169 TRP n 
1 170 GLU n 
1 171 LEU n 
1 172 VAL n 
1 173 ASP n 
1 174 LYS n 
1 175 GLU n 
1 176 ARG n 
1 177 ASN n 
1 178 LEU n 
1 179 HIS n 
1 180 LEU n 
1 181 GLU n 
1 182 GLY n 
1 183 LYS n 
1 184 CYS n 
1 185 GLU n 
1 186 THR n 
1 187 CYS n 
1 188 VAL n 
1 189 TYR n 
1 190 ASN n 
1 191 MET n 
1 192 MET n 
1 193 GLY n 
1 194 LYS n 
1 195 ARG n 
1 196 GLU n 
1 197 LYS n 
1 198 LYS n 
1 199 LEU n 
1 200 GLY n 
1 201 GLU n 
1 202 PHE n 
1 203 GLY n 
1 204 LYS n 
1 205 ALA n 
1 206 LYS n 
1 207 GLY n 
1 208 SER n 
1 209 ARG n 
1 210 ALA n 
1 211 ILE n 
1 212 TRP n 
1 213 TYR n 
1 214 MET n 
1 215 TRP n 
1 216 LEU n 
1 217 GLY n 
1 218 ALA n 
1 219 ARG n 
1 220 PHE n 
1 221 LEU n 
1 222 GLU n 
1 223 PHE n 
1 224 GLU n 
1 225 ALA n 
1 226 LEU n 
1 227 GLY n 
1 228 PHE n 
1 229 LEU n 
1 230 ASN n 
1 231 GLU n 
1 232 ASP n 
1 233 HIS n 
1 234 TRP n 
1 235 PHE n 
1 236 SER n 
1 237 ARG n 
1 238 GLU n 
1 239 ASN n 
1 240 SER n 
1 241 LEU n 
1 242 SER n 
1 243 GLY n 
1 244 VAL n 
1 245 GLU n 
1 246 GLY n 
1 247 GLU n 
1 248 GLY n 
1 249 LEU n 
1 250 HIS n 
1 251 LYS n 
1 252 LEU n 
1 253 GLY n 
1 254 TYR n 
1 255 ILE n 
1 256 LEU n 
1 257 ARG n 
1 258 ASP n 
1 259 VAL n 
1 260 SER n 
1 261 LYS n 
1 262 LYS n 
1 263 GLU n 
1 264 GLY n 
1 265 GLY n 
1 266 ALA n 
1 267 MET n 
1 268 TYR n 
1 269 ALA n 
1 270 ASP n 
1 271 ASP n 
1 272 THR n 
1 273 ALA n 
1 274 GLY n 
1 275 TRP n 
1 276 ASP n 
1 277 THR n 
1 278 ARG n 
1 279 ILE n 
1 280 THR n 
1 281 LEU n 
1 282 GLU n 
1 283 ASP n 
1 284 LEU n 
1 285 LYS n 
1 286 ASN n 
1 287 GLU n 
1 288 GLU n 
1 289 MET n 
1 290 VAL n 
1 291 THR n 
1 292 ASN n 
1 293 HIS n 
1 294 MET n 
1 295 GLU n 
1 296 GLY n 
1 297 GLU n 
1 298 HIS n 
1 299 LYS n 
1 300 LYS n 
1 301 LEU n 
1 302 ALA n 
1 303 GLU n 
1 304 ALA n 
1 305 ILE n 
1 306 PHE n 
1 307 LYS n 
1 308 LEU n 
1 309 THR n 
1 310 TYR n 
1 311 GLN n 
1 312 ASN n 
1 313 LYS n 
1 314 VAL n 
1 315 VAL n 
1 316 ARG n 
1 317 VAL n 
1 318 GLN n 
1 319 ARG n 
1 320 PRO n 
1 321 THR n 
1 322 PRO n 
1 323 ARG n 
1 324 GLY n 
1 325 THR n 
1 326 VAL n 
1 327 MET n 
1 328 ASP n 
1 329 ILE n 
1 330 ILE n 
1 331 SER n 
1 332 ARG n 
1 333 ARG n 
1 334 ASP n 
1 335 GLN n 
1 336 ARG n 
1 337 GLY n 
1 338 SER n 
1 339 GLY n 
1 340 GLN n 
1 341 VAL n 
1 342 VAL n 
1 343 THR n 
1 344 TYR n 
1 345 GLY n 
1 346 LEU n 
1 347 ASN n 
1 348 THR n 
1 349 PHE n 
1 350 THR n 
1 351 ASN n 
1 352 MET n 
1 353 GLU n 
1 354 ALA n 
1 355 GLN n 
1 356 LEU n 
1 357 ILE n 
1 358 ARG n 
1 359 GLN n 
1 360 MET n 
1 361 GLU n 
1 362 GLY n 
1 363 GLU n 
1 364 GLY n 
1 365 VAL n 
1 366 PHE n 
1 367 LYS n 
1 368 SER n 
1 369 ILE n 
1 370 GLN n 
1 371 HIS n 
1 372 LEU n 
1 373 THR n 
1 374 VAL n 
1 375 THR n 
1 376 GLU n 
1 377 GLU n 
1 378 ILE n 
1 379 ALA n 
1 380 VAL n 
1 381 LYS n 
1 382 ASN n 
1 383 TRP n 
1 384 LEU n 
1 385 VAL n 
1 386 ARG n 
1 387 VAL n 
1 388 GLY n 
1 389 ARG n 
1 390 GLU n 
1 391 ARG n 
1 392 LEU n 
1 393 SER n 
1 394 ARG n 
1 395 MET n 
1 396 ALA n 
1 397 ILE n 
1 398 SER n 
1 399 GLY n 
1 400 ASP n 
1 401 ASP n 
1 402 CYS n 
1 403 VAL n 
1 404 VAL n 
1 405 LYS n 
1 406 PRO n 
1 407 LEU n 
1 408 ASP n 
1 409 ASP n 
1 410 ARG n 
1 411 PHE n 
1 412 ALA n 
1 413 SER n 
1 414 ALA n 
1 415 LEU n 
1 416 THR n 
1 417 ALA n 
1 418 LEU n 
1 419 ASN n 
1 420 ASP n 
1 421 MET n 
1 422 GLY n 
1 423 LYS n 
1 424 VAL n 
1 425 ARG n 
1 426 LYS n 
1 427 ASP n 
1 428 ILE n 
1 429 GLN n 
1 430 GLN n 
1 431 TRP n 
1 432 GLU n 
1 433 PRO n 
1 434 SER n 
1 435 ARG n 
1 436 GLY n 
1 437 TRP n 
1 438 ASN n 
1 439 ASP n 
1 440 TRP n 
1 441 THR n 
1 442 GLN n 
1 443 VAL n 
1 444 PRO n 
1 445 PHE n 
1 446 CYS n 
1 447 SER n 
1 448 HIS n 
1 449 HIS n 
1 450 PHE n 
1 451 HIS n 
1 452 GLU n 
1 453 LEU n 
1 454 ILE n 
1 455 MET n 
1 456 LYS n 
1 457 ASP n 
1 458 GLY n 
1 459 ARG n 
1 460 VAL n 
1 461 LEU n 
1 462 VAL n 
1 463 VAL n 
1 464 PRO n 
1 465 CYS n 
1 466 ARG n 
1 467 ASN n 
1 468 GLN n 
1 469 ASP n 
1 470 GLU n 
1 471 LEU n 
1 472 ILE n 
1 473 GLY n 
1 474 ARG n 
1 475 ALA n 
1 476 ARG n 
1 477 ILE n 
1 478 SER n 
1 479 GLN n 
1 480 GLY n 
1 481 ALA n 
1 482 GLY n 
1 483 TRP n 
1 484 SER n 
1 485 LEU n 
1 486 ARG n 
1 487 GLU n 
1 488 THR n 
1 489 ALA n 
1 490 CYS n 
1 491 LEU n 
1 492 GLY n 
1 493 LYS n 
1 494 SER n 
1 495 TYR n 
1 496 ALA n 
1 497 GLN n 
1 498 MET n 
1 499 TRP n 
1 500 SER n 
1 501 LEU n 
1 502 MET n 
1 503 TYR n 
1 504 PHE n 
1 505 HIS n 
1 506 ARG n 
1 507 ARG n 
1 508 ASP n 
1 509 LEU n 
1 510 ARG n 
1 511 LEU n 
1 512 ALA n 
1 513 ALA n 
1 514 ASN n 
1 515 ALA n 
1 516 ILE n 
1 517 CYS n 
1 518 SER n 
1 519 ALA n 
1 520 VAL n 
1 521 PRO n 
1 522 SER n 
1 523 HIS n 
1 524 TRP n 
1 525 VAL n 
1 526 PRO n 
1 527 THR n 
1 528 SER n 
1 529 ARG n 
1 530 THR n 
1 531 THR n 
1 532 TRP n 
1 533 SER n 
1 534 ILE n 
1 535 HIS n 
1 536 ALA n 
1 537 THR n 
1 538 HIS n 
1 539 GLU n 
1 540 TRP n 
1 541 MET n 
1 542 THR n 
1 543 THR n 
1 544 GLU n 
1 545 ASP n 
1 546 MET n 
1 547 LEU n 
1 548 THR n 
1 549 VAL n 
1 550 TRP n 
1 551 ASN n 
1 552 ARG n 
1 553 VAL n 
1 554 TRP n 
1 555 ILE n 
1 556 GLN n 
1 557 GLU n 
1 558 ASN n 
1 559 PRO n 
1 560 TRP n 
1 561 MET n 
1 562 GLU n 
1 563 ASP n 
1 564 LYS n 
1 565 THR n 
1 566 PRO n 
1 567 VAL n 
1 568 GLU n 
1 569 SER n 
1 570 TRP n 
1 571 GLU n 
1 572 GLU n 
1 573 ILE n 
1 574 PRO n 
1 575 TYR n 
1 576 LEU n 
1 577 GLY n 
1 578 LYS n 
1 579 ARG n 
1 580 GLU n 
1 581 ASP n 
1 582 GLN n 
1 583 TRP n 
1 584 CYS n 
1 585 GLY n 
1 586 SER n 
1 587 LEU n 
1 588 ILE n 
1 589 GLY n 
1 590 LEU n 
1 591 THR n 
1 592 SER n 
1 593 ARG n 
1 594 ALA n 
1 595 THR n 
1 596 TRP n 
1 597 ALA n 
1 598 LYS n 
1 599 ASN n 
1 600 ILE n 
1 601 GLN n 
1 602 THR n 
1 603 ALA n 
1 604 ILE n 
1 605 ASN n 
1 606 GLN n 
1 607 VAL n 
1 608 ARG n 
1 609 SER n 
1 610 LEU n 
1 611 ILE n 
1 612 GLY n 
1 613 ASN n 
1 614 GLU n 
1 615 GLU n 
1 616 TYR n 
1 617 THR n 
1 618 ASP n 
1 619 TYR n 
1 620 MET n 
1 621 PRO n 
1 622 SER n 
1 623 MET n 
1 624 LYS n 
1 625 ARG n 
1 626 PHE n 
1 627 ARG n 
1 628 ARG n 
1 629 GLU n 
1 630 GLU n 
1 631 GLU n 
1 632 GLU n 
1 633 ALA n 
1 634 GLY n 
1 635 VAL n 
1 636 LEU n 
1 637 TRP n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   637 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'dengue virus type 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     11060 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                 ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE                                ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE                              ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                         ? 'C4 H7 N O4'     133.103 
B1A non-polymer         . '~{N}-(4-phenylazanylphenyl)ethanamide' ? 'C14 H14 N2 O'   226.274 
CL  non-polymer         . 'CHLORIDE ION'                          ? 'Cl -1'          35.453  
CYS 'L-peptide linking' y CYSTEINE                                ? 'C3 H7 N O2 S'   121.158 
DMS non-polymer         . 'DIMETHYL SULFOXIDE'                    ? 'C2 H6 O S'      78.133  
GLN 'L-peptide linking' y GLUTAMINE                               ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                         ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                                 ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE                               ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                                   ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE                              ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE                                 ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                                  ? 'C6 H15 N2 O2 1' 147.195 
MES non-polymer         . '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'  ? 'C6 H13 N O4 S'  195.237 
MET 'L-peptide linking' y METHIONINE                              ? 'C5 H11 N O2 S'  149.211 
PEG non-polymer         . 'DI(HYDROXYETHYL)ETHER'                 ? 'C4 H10 O3'      106.120 
PHE 'L-peptide linking' y PHENYLALANINE                           ? 'C9 H11 N O2'    165.189 
PO4 non-polymer         . 'PHOSPHATE ION'                         ? 'O4 P -3'        94.971  
PRO 'L-peptide linking' y PROLINE                                 ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                                  ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE                               ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                              ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE                                ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE                                  ? 'C5 H11 N O2'    117.146 
ZN  non-polymer         . 'ZINC ION'                              ? 'Zn 2'           65.409  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   264 ?   ?   ?   A . n 
A 1 2   PRO 2   265 ?   ?   ?   A . n 
A 1 3   GLY 3   266 ?   ?   ?   A . n 
A 1 4   ILE 4   267 ?   ?   ?   A . n 
A 1 5   GLU 5   268 ?   ?   ?   A . n 
A 1 6   SER 6   269 ?   ?   ?   A . n 
A 1 7   GLU 7   270 ?   ?   ?   A . n 
A 1 8   THR 8   271 ?   ?   ?   A . n 
A 1 9   PRO 9   272 ?   ?   ?   A . n 
A 1 10  ASN 10  273 273 ASN ASN A . n 
A 1 11  LEU 11  274 274 LEU LEU A . n 
A 1 12  ASP 12  275 275 ASP ASP A . n 
A 1 13  ILE 13  276 276 ILE ILE A . n 
A 1 14  ILE 14  277 277 ILE ILE A . n 
A 1 15  GLY 15  278 278 GLY GLY A . n 
A 1 16  LYS 16  279 279 LYS LYS A . n 
A 1 17  ARG 17  280 280 ARG ARG A . n 
A 1 18  ILE 18  281 281 ILE ILE A . n 
A 1 19  GLU 19  282 282 GLU GLU A . n 
A 1 20  LYS 20  283 283 LYS LYS A . n 
A 1 21  ILE 21  284 284 ILE ILE A . n 
A 1 22  LYS 22  285 285 LYS LYS A . n 
A 1 23  GLN 23  286 286 GLN GLN A . n 
A 1 24  GLU 24  287 287 GLU GLU A . n 
A 1 25  HIS 25  288 288 HIS HIS A . n 
A 1 26  GLU 26  289 289 GLU GLU A . n 
A 1 27  THR 27  290 290 THR THR A . n 
A 1 28  SER 28  291 291 SER SER A . n 
A 1 29  TRP 29  292 292 TRP TRP A . n 
A 1 30  HIS 30  293 293 HIS HIS A . n 
A 1 31  TYR 31  294 294 TYR TYR A . n 
A 1 32  ASP 32  295 295 ASP ASP A . n 
A 1 33  GLN 33  296 296 GLN GLN A . n 
A 1 34  ASP 34  297 297 ASP ASP A . n 
A 1 35  HIS 35  298 298 HIS HIS A . n 
A 1 36  PRO 36  299 299 PRO PRO A . n 
A 1 37  TYR 37  300 300 TYR TYR A . n 
A 1 38  LYS 38  301 301 LYS LYS A . n 
A 1 39  THR 39  302 302 THR THR A . n 
A 1 40  TRP 40  303 303 TRP TRP A . n 
A 1 41  ALA 41  304 304 ALA ALA A . n 
A 1 42  TYR 42  305 305 TYR TYR A . n 
A 1 43  HIS 43  306 306 HIS HIS A . n 
A 1 44  GLY 44  307 307 GLY GLY A . n 
A 1 45  SER 45  308 308 SER SER A . n 
A 1 46  TYR 46  309 309 TYR TYR A . n 
A 1 47  GLU 47  310 310 GLU GLU A . n 
A 1 48  THR 48  311 311 THR THR A . n 
A 1 49  LYS 49  312 ?   ?   ?   A . n 
A 1 50  GLN 50  313 ?   ?   ?   A . n 
A 1 51  THR 51  314 ?   ?   ?   A . n 
A 1 52  GLY 52  315 ?   ?   ?   A . n 
A 1 53  SER 53  316 ?   ?   ?   A . n 
A 1 54  ALA 54  317 317 ALA ALA A . n 
A 1 55  SER 55  318 318 SER SER A . n 
A 1 56  SER 56  319 319 SER SER A . n 
A 1 57  MET 57  320 320 MET MET A . n 
A 1 58  VAL 58  321 321 VAL VAL A . n 
A 1 59  ASN 59  322 322 ASN ASN A . n 
A 1 60  GLY 60  323 323 GLY GLY A . n 
A 1 61  VAL 61  324 324 VAL VAL A . n 
A 1 62  VAL 62  325 325 VAL VAL A . n 
A 1 63  ARG 63  326 326 ARG ARG A . n 
A 1 64  LEU 64  327 327 LEU LEU A . n 
A 1 65  LEU 65  328 328 LEU LEU A . n 
A 1 66  THR 66  329 329 THR THR A . n 
A 1 67  LYS 67  330 330 LYS LYS A . n 
A 1 68  PRO 68  331 331 PRO PRO A . n 
A 1 69  TRP 69  332 332 TRP TRP A . n 
A 1 70  ASP 70  333 333 ASP ASP A . n 
A 1 71  ILE 71  334 334 ILE ILE A . n 
A 1 72  ILE 72  335 335 ILE ILE A . n 
A 1 73  PRO 73  336 336 PRO PRO A . n 
A 1 74  MET 74  337 337 MET MET A . n 
A 1 75  VAL 75  338 338 VAL VAL A . n 
A 1 76  THR 76  339 339 THR THR A . n 
A 1 77  GLN 77  340 340 GLN GLN A . n 
A 1 78  MET 78  341 341 MET MET A . n 
A 1 79  ALA 79  342 342 ALA ALA A . n 
A 1 80  MET 80  343 343 MET MET A . n 
A 1 81  THR 81  344 344 THR GLY A . n 
A 1 82  ASP 82  345 ?   ?   ?   A . n 
A 1 83  THR 83  346 ?   ?   ?   A . n 
A 1 84  THR 84  347 ?   ?   ?   A . n 
A 1 85  PRO 85  348 ?   ?   ?   A . n 
A 1 86  PHE 86  349 ?   ?   ?   A . n 
A 1 87  GLY 87  350 ?   ?   ?   A . n 
A 1 88  GLN 88  351 ?   ?   ?   A . n 
A 1 89  GLN 89  352 ?   ?   ?   A . n 
A 1 90  ARG 90  353 ?   ?   ?   A . n 
A 1 91  VAL 91  354 ?   ?   ?   A . n 
A 1 92  PHE 92  355 ?   ?   ?   A . n 
A 1 93  LYS 93  356 356 LYS LYS A . n 
A 1 94  GLU 94  357 357 GLU GLU A . n 
A 1 95  LYS 95  358 358 LYS LYS A . n 
A 1 96  VAL 96  359 359 VAL VAL A . n 
A 1 97  ASP 97  360 360 ASP ASP A . n 
A 1 98  THR 98  361 361 THR THR A . n 
A 1 99  ARG 99  362 362 ARG ARG A . n 
A 1 100 THR 100 363 363 THR THR A . n 
A 1 101 GLN 101 364 364 GLN GLN A . n 
A 1 102 GLU 102 365 365 GLU GLU A . n 
A 1 103 PRO 103 366 366 PRO PRO A . n 
A 1 104 LYS 104 367 367 LYS LYS A . n 
A 1 105 GLU 105 368 368 GLU GLU A . n 
A 1 106 GLY 106 369 369 GLY GLY A . n 
A 1 107 THR 107 370 370 THR THR A . n 
A 1 108 LYS 108 371 371 LYS LYS A . n 
A 1 109 LYS 109 372 372 LYS LYS A . n 
A 1 110 LEU 110 373 373 LEU LEU A . n 
A 1 111 MET 111 374 374 MET MET A . n 
A 1 112 LYS 112 375 375 LYS LYS A . n 
A 1 113 ILE 113 376 376 ILE ILE A . n 
A 1 114 THR 114 377 377 THR THR A . n 
A 1 115 ALA 115 378 378 ALA ALA A . n 
A 1 116 GLU 116 379 379 GLU GLU A . n 
A 1 117 TRP 117 380 380 TRP TRP A . n 
A 1 118 LEU 118 381 381 LEU LEU A . n 
A 1 119 TRP 119 382 382 TRP TRP A . n 
A 1 120 LYS 120 383 383 LYS LYS A . n 
A 1 121 GLU 121 384 384 GLU GLU A . n 
A 1 122 LEU 122 385 385 LEU LEU A . n 
A 1 123 GLY 123 386 386 GLY GLY A . n 
A 1 124 LYS 124 387 387 LYS LYS A . n 
A 1 125 LYS 125 388 388 LYS LYS A . n 
A 1 126 LYS 126 389 389 LYS LYS A . n 
A 1 127 THR 127 390 390 THR THR A . n 
A 1 128 PRO 128 391 391 PRO PRO A . n 
A 1 129 ARG 129 392 392 ARG ARG A . n 
A 1 130 MET 130 393 393 MET MET A . n 
A 1 131 CYS 131 394 394 CYS CYS A . n 
A 1 132 THR 132 395 395 THR THR A . n 
A 1 133 ARG 133 396 396 ARG ARG A . n 
A 1 134 GLU 134 397 397 GLU GLU A . n 
A 1 135 GLU 135 398 398 GLU GLU A . n 
A 1 136 PHE 136 399 399 PHE PHE A . n 
A 1 137 THR 137 400 400 THR THR A . n 
A 1 138 ARG 138 401 401 ARG ARG A . n 
A 1 139 LYS 139 402 402 LYS LYS A . n 
A 1 140 VAL 140 403 403 VAL VAL A . n 
A 1 141 ARG 141 404 404 ARG ARG A . n 
A 1 142 SER 142 405 405 SER SER A . n 
A 1 143 ASN 143 406 406 ASN ASN A . n 
A 1 144 ALA 144 407 407 ALA ALA A . n 
A 1 145 ALA 145 408 408 ALA ALA A . n 
A 1 146 LEU 146 409 409 LEU LEU A . n 
A 1 147 GLY 147 410 410 GLY GLY A . n 
A 1 148 ALA 148 411 411 ALA ALA A . n 
A 1 149 ILE 149 412 412 ILE ILE A . n 
A 1 150 PHE 150 413 ?   ?   ?   A . n 
A 1 151 THR 151 414 ?   ?   ?   A . n 
A 1 152 ASP 152 415 ?   ?   ?   A . n 
A 1 153 GLU 153 416 ?   ?   ?   A . n 
A 1 154 ASN 154 417 ?   ?   ?   A . n 
A 1 155 LYS 155 418 418 LYS LYS A . n 
A 1 156 TRP 156 419 419 TRP TRP A . n 
A 1 157 LYS 157 420 420 LYS LYS A . n 
A 1 158 SER 158 421 421 SER SER A . n 
A 1 159 ALA 159 422 422 ALA ALA A . n 
A 1 160 ARG 160 423 423 ARG ARG A . n 
A 1 161 GLU 161 424 424 GLU GLU A . n 
A 1 162 ALA 162 425 425 ALA ALA A . n 
A 1 163 VAL 163 426 426 VAL VAL A . n 
A 1 164 GLU 164 427 427 GLU GLU A . n 
A 1 165 ASP 165 428 428 ASP ASP A . n 
A 1 166 SER 166 429 429 SER SER A . n 
A 1 167 GLY 167 430 430 GLY GLY A . n 
A 1 168 PHE 168 431 431 PHE PHE A . n 
A 1 169 TRP 169 432 432 TRP TRP A . n 
A 1 170 GLU 170 433 433 GLU GLU A . n 
A 1 171 LEU 171 434 434 LEU LEU A . n 
A 1 172 VAL 172 435 435 VAL VAL A . n 
A 1 173 ASP 173 436 436 ASP ASP A . n 
A 1 174 LYS 174 437 437 LYS LYS A . n 
A 1 175 GLU 175 438 438 GLU GLU A . n 
A 1 176 ARG 176 439 439 ARG ARG A . n 
A 1 177 ASN 177 440 440 ASN ASN A . n 
A 1 178 LEU 178 441 441 LEU LEU A . n 
A 1 179 HIS 179 442 442 HIS HIS A . n 
A 1 180 LEU 180 443 443 LEU LEU A . n 
A 1 181 GLU 181 444 444 GLU GLU A . n 
A 1 182 GLY 182 445 445 GLY GLY A . n 
A 1 183 LYS 183 446 446 LYS LYS A . n 
A 1 184 CYS 184 447 447 CYS CYS A . n 
A 1 185 GLU 185 448 448 GLU GLU A . n 
A 1 186 THR 186 449 449 THR THR A . n 
A 1 187 CYS 187 450 450 CYS CYS A . n 
A 1 188 VAL 188 451 451 VAL VAL A . n 
A 1 189 TYR 189 452 452 TYR TYR A . n 
A 1 190 ASN 190 453 453 ASN ASN A . n 
A 1 191 MET 191 454 454 MET MET A . n 
A 1 192 MET 192 455 455 MET MET A . n 
A 1 193 GLY 193 456 ?   ?   ?   A . n 
A 1 194 LYS 194 457 ?   ?   ?   A . n 
A 1 195 ARG 195 458 ?   ?   ?   A . n 
A 1 196 GLU 196 459 ?   ?   ?   A . n 
A 1 197 LYS 197 460 ?   ?   ?   A . n 
A 1 198 LYS 198 461 ?   ?   ?   A . n 
A 1 199 LEU 199 462 ?   ?   ?   A . n 
A 1 200 GLY 200 463 ?   ?   ?   A . n 
A 1 201 GLU 201 464 ?   ?   ?   A . n 
A 1 202 PHE 202 465 ?   ?   ?   A . n 
A 1 203 GLY 203 466 ?   ?   ?   A . n 
A 1 204 LYS 204 467 ?   ?   ?   A . n 
A 1 205 ALA 205 468 ?   ?   ?   A . n 
A 1 206 LYS 206 469 ?   ?   ?   A . n 
A 1 207 GLY 207 470 ?   ?   ?   A . n 
A 1 208 SER 208 471 ?   ?   ?   A . n 
A 1 209 ARG 209 472 ?   ?   ?   A . n 
A 1 210 ALA 210 473 473 ALA ALA A . n 
A 1 211 ILE 211 474 474 ILE ILE A . n 
A 1 212 TRP 212 475 475 TRP TRP A . n 
A 1 213 TYR 213 476 476 TYR TYR A . n 
A 1 214 MET 214 477 477 MET MET A . n 
A 1 215 TRP 215 478 478 TRP TRP A . n 
A 1 216 LEU 216 479 479 LEU LEU A . n 
A 1 217 GLY 217 480 480 GLY GLY A . n 
A 1 218 ALA 218 481 481 ALA ALA A . n 
A 1 219 ARG 219 482 482 ARG ARG A . n 
A 1 220 PHE 220 483 483 PHE PHE A . n 
A 1 221 LEU 221 484 484 LEU LEU A . n 
A 1 222 GLU 222 485 485 GLU GLU A . n 
A 1 223 PHE 223 486 486 PHE PHE A . n 
A 1 224 GLU 224 487 487 GLU GLU A . n 
A 1 225 ALA 225 488 488 ALA ALA A . n 
A 1 226 LEU 226 489 489 LEU LEU A . n 
A 1 227 GLY 227 490 490 GLY GLY A . n 
A 1 228 PHE 228 491 491 PHE PHE A . n 
A 1 229 LEU 229 492 492 LEU LEU A . n 
A 1 230 ASN 230 493 493 ASN ASN A . n 
A 1 231 GLU 231 494 494 GLU GLU A . n 
A 1 232 ASP 232 495 495 ASP ASP A . n 
A 1 233 HIS 233 496 496 HIS HIS A . n 
A 1 234 TRP 234 497 497 TRP TRP A . n 
A 1 235 PHE 235 498 498 PHE PHE A . n 
A 1 236 SER 236 499 499 SER SER A . n 
A 1 237 ARG 237 500 500 ARG ARG A . n 
A 1 238 GLU 238 501 501 GLU GLU A . n 
A 1 239 ASN 239 502 502 ASN ASN A . n 
A 1 240 SER 240 503 503 SER SER A . n 
A 1 241 LEU 241 504 504 LEU LEU A . n 
A 1 242 SER 242 505 505 SER SER A . n 
A 1 243 GLY 243 506 506 GLY GLY A . n 
A 1 244 VAL 244 507 507 VAL VAL A . n 
A 1 245 GLU 245 508 508 GLU GLU A . n 
A 1 246 GLY 246 509 509 GLY GLY A . n 
A 1 247 GLU 247 510 510 GLU GLU A . n 
A 1 248 GLY 248 511 511 GLY GLY A . n 
A 1 249 LEU 249 512 512 LEU LEU A . n 
A 1 250 HIS 250 513 513 HIS HIS A . n 
A 1 251 LYS 251 514 514 LYS LYS A . n 
A 1 252 LEU 252 515 515 LEU LEU A . n 
A 1 253 GLY 253 516 516 GLY GLY A . n 
A 1 254 TYR 254 517 517 TYR TYR A . n 
A 1 255 ILE 255 518 518 ILE ILE A . n 
A 1 256 LEU 256 519 519 LEU LEU A . n 
A 1 257 ARG 257 520 520 ARG ARG A . n 
A 1 258 ASP 258 521 521 ASP ASP A . n 
A 1 259 VAL 259 522 522 VAL VAL A . n 
A 1 260 SER 260 523 523 SER SER A . n 
A 1 261 LYS 261 524 524 LYS LYS A . n 
A 1 262 LYS 262 525 525 LYS LYS A . n 
A 1 263 GLU 263 526 526 GLU GLU A . n 
A 1 264 GLY 264 527 527 GLY GLY A . n 
A 1 265 GLY 265 528 528 GLY GLY A . n 
A 1 266 ALA 266 529 529 ALA ALA A . n 
A 1 267 MET 267 530 530 MET MET A . n 
A 1 268 TYR 268 531 531 TYR TYR A . n 
A 1 269 ALA 269 532 532 ALA ALA A . n 
A 1 270 ASP 270 533 533 ASP ASP A . n 
A 1 271 ASP 271 534 534 ASP ASP A . n 
A 1 272 THR 272 535 535 THR THR A . n 
A 1 273 ALA 273 536 536 ALA ALA A . n 
A 1 274 GLY 274 537 537 GLY GLY A . n 
A 1 275 TRP 275 538 538 TRP TRP A . n 
A 1 276 ASP 276 539 539 ASP ASP A . n 
A 1 277 THR 277 540 540 THR THR A . n 
A 1 278 ARG 278 541 541 ARG ARG A . n 
A 1 279 ILE 279 542 542 ILE ILE A . n 
A 1 280 THR 280 543 543 THR THR A . n 
A 1 281 LEU 281 544 544 LEU LEU A . n 
A 1 282 GLU 282 545 545 GLU GLU A . n 
A 1 283 ASP 283 546 546 ASP ASP A . n 
A 1 284 LEU 284 547 547 LEU LEU A . n 
A 1 285 LYS 285 548 548 LYS LYS A . n 
A 1 286 ASN 286 549 549 ASN ASN A . n 
A 1 287 GLU 287 550 550 GLU GLU A . n 
A 1 288 GLU 288 551 551 GLU GLU A . n 
A 1 289 MET 289 552 552 MET MET A . n 
A 1 290 VAL 290 553 553 VAL VAL A . n 
A 1 291 THR 291 554 554 THR THR A . n 
A 1 292 ASN 292 555 555 ASN ASN A . n 
A 1 293 HIS 293 556 556 HIS HIS A . n 
A 1 294 MET 294 557 557 MET MET A . n 
A 1 295 GLU 295 558 558 GLU GLU A . n 
A 1 296 GLY 296 559 559 GLY GLY A . n 
A 1 297 GLU 297 560 560 GLU GLU A . n 
A 1 298 HIS 298 561 561 HIS HIS A . n 
A 1 299 LYS 299 562 562 LYS LYS A . n 
A 1 300 LYS 300 563 563 LYS LYS A . n 
A 1 301 LEU 301 564 564 LEU LEU A . n 
A 1 302 ALA 302 565 565 ALA ALA A . n 
A 1 303 GLU 303 566 566 GLU GLU A . n 
A 1 304 ALA 304 567 567 ALA ALA A . n 
A 1 305 ILE 305 568 568 ILE ILE A . n 
A 1 306 PHE 306 569 569 PHE PHE A . n 
A 1 307 LYS 307 570 570 LYS LYS A . n 
A 1 308 LEU 308 571 571 LEU LEU A . n 
A 1 309 THR 309 572 572 THR THR A . n 
A 1 310 TYR 310 573 573 TYR TYR A . n 
A 1 311 GLN 311 574 574 GLN GLN A . n 
A 1 312 ASN 312 575 575 ASN ASN A . n 
A 1 313 LYS 313 576 576 LYS LYS A . n 
A 1 314 VAL 314 577 577 VAL VAL A . n 
A 1 315 VAL 315 578 578 VAL VAL A . n 
A 1 316 ARG 316 579 579 ARG ARG A . n 
A 1 317 VAL 317 580 580 VAL VAL A . n 
A 1 318 GLN 318 581 581 GLN GLN A . n 
A 1 319 ARG 319 582 582 ARG ARG A . n 
A 1 320 PRO 320 583 583 PRO PRO A . n 
A 1 321 THR 321 584 584 THR THR A . n 
A 1 322 PRO 322 585 ?   ?   ?   A . n 
A 1 323 ARG 323 586 ?   ?   ?   A . n 
A 1 324 GLY 324 587 ?   ?   ?   A . n 
A 1 325 THR 325 588 588 THR THR A . n 
A 1 326 VAL 326 589 589 VAL VAL A . n 
A 1 327 MET 327 590 590 MET MET A . n 
A 1 328 ASP 328 591 591 ASP ASP A . n 
A 1 329 ILE 329 592 592 ILE ILE A . n 
A 1 330 ILE 330 593 593 ILE ILE A . n 
A 1 331 SER 331 594 594 SER SER A . n 
A 1 332 ARG 332 595 595 ARG ARG A . n 
A 1 333 ARG 333 596 596 ARG ARG A . n 
A 1 334 ASP 334 597 597 ASP ASP A . n 
A 1 335 GLN 335 598 598 GLN GLN A . n 
A 1 336 ARG 336 599 599 ARG ARG A . n 
A 1 337 GLY 337 600 600 GLY GLY A . n 
A 1 338 SER 338 601 601 SER SER A . n 
A 1 339 GLY 339 602 602 GLY GLY A . n 
A 1 340 GLN 340 603 603 GLN GLN A . n 
A 1 341 VAL 341 604 604 VAL VAL A . n 
A 1 342 VAL 342 605 605 VAL VAL A . n 
A 1 343 THR 343 606 606 THR THR A . n 
A 1 344 TYR 344 607 607 TYR TYR A . n 
A 1 345 GLY 345 608 608 GLY GLY A . n 
A 1 346 LEU 346 609 609 LEU LEU A . n 
A 1 347 ASN 347 610 610 ASN ASN A . n 
A 1 348 THR 348 611 611 THR THR A . n 
A 1 349 PHE 349 612 612 PHE PHE A . n 
A 1 350 THR 350 613 613 THR THR A . n 
A 1 351 ASN 351 614 614 ASN ASN A . n 
A 1 352 MET 352 615 615 MET MET A . n 
A 1 353 GLU 353 616 616 GLU GLU A . n 
A 1 354 ALA 354 617 617 ALA ALA A . n 
A 1 355 GLN 355 618 618 GLN GLN A . n 
A 1 356 LEU 356 619 619 LEU LEU A . n 
A 1 357 ILE 357 620 620 ILE ILE A . n 
A 1 358 ARG 358 621 621 ARG ARG A . n 
A 1 359 GLN 359 622 622 GLN GLN A . n 
A 1 360 MET 360 623 623 MET MET A . n 
A 1 361 GLU 361 624 624 GLU GLU A . n 
A 1 362 GLY 362 625 625 GLY GLY A . n 
A 1 363 GLU 363 626 626 GLU GLU A . n 
A 1 364 GLY 364 627 627 GLY GLY A . n 
A 1 365 VAL 365 628 628 VAL VAL A . n 
A 1 366 PHE 366 629 629 PHE PHE A . n 
A 1 367 LYS 367 630 630 LYS LYS A . n 
A 1 368 SER 368 631 631 SER SER A . n 
A 1 369 ILE 369 632 632 ILE ILE A . n 
A 1 370 GLN 370 633 633 GLN GLN A . n 
A 1 371 HIS 371 634 634 HIS HIS A . n 
A 1 372 LEU 372 635 635 LEU LEU A . n 
A 1 373 THR 373 636 636 THR THR A . n 
A 1 374 VAL 374 637 637 VAL VAL A . n 
A 1 375 THR 375 638 638 THR THR A . n 
A 1 376 GLU 376 639 639 GLU GLU A . n 
A 1 377 GLU 377 640 640 GLU GLU A . n 
A 1 378 ILE 378 641 641 ILE ILE A . n 
A 1 379 ALA 379 642 642 ALA ALA A . n 
A 1 380 VAL 380 643 643 VAL VAL A . n 
A 1 381 LYS 381 644 644 LYS LYS A . n 
A 1 382 ASN 382 645 645 ASN ASN A . n 
A 1 383 TRP 383 646 646 TRP TRP A . n 
A 1 384 LEU 384 647 647 LEU LEU A . n 
A 1 385 VAL 385 648 648 VAL VAL A . n 
A 1 386 ARG 386 649 649 ARG ARG A . n 
A 1 387 VAL 387 650 650 VAL VAL A . n 
A 1 388 GLY 388 651 651 GLY GLY A . n 
A 1 389 ARG 389 652 652 ARG ARG A . n 
A 1 390 GLU 390 653 653 GLU GLU A . n 
A 1 391 ARG 391 654 654 ARG ARG A . n 
A 1 392 LEU 392 655 655 LEU LEU A . n 
A 1 393 SER 393 656 656 SER SER A . n 
A 1 394 ARG 394 657 657 ARG ARG A . n 
A 1 395 MET 395 658 658 MET MET A . n 
A 1 396 ALA 396 659 659 ALA ALA A . n 
A 1 397 ILE 397 660 660 ILE ILE A . n 
A 1 398 SER 398 661 661 SER SER A . n 
A 1 399 GLY 399 662 662 GLY GLY A . n 
A 1 400 ASP 400 663 663 ASP ASP A . n 
A 1 401 ASP 401 664 664 ASP ASP A . n 
A 1 402 CYS 402 665 665 CYS CYS A . n 
A 1 403 VAL 403 666 666 VAL VAL A . n 
A 1 404 VAL 404 667 667 VAL VAL A . n 
A 1 405 LYS 405 668 668 LYS LYS A . n 
A 1 406 PRO 406 669 669 PRO PRO A . n 
A 1 407 LEU 407 670 670 LEU LEU A . n 
A 1 408 ASP 408 671 671 ASP ASP A . n 
A 1 409 ASP 409 672 672 ASP ASP A . n 
A 1 410 ARG 410 673 673 ARG ARG A . n 
A 1 411 PHE 411 674 674 PHE PHE A . n 
A 1 412 ALA 412 675 675 ALA ALA A . n 
A 1 413 SER 413 676 676 SER SER A . n 
A 1 414 ALA 414 677 677 ALA ALA A . n 
A 1 415 LEU 415 678 678 LEU LEU A . n 
A 1 416 THR 416 679 679 THR THR A . n 
A 1 417 ALA 417 680 680 ALA ALA A . n 
A 1 418 LEU 418 681 681 LEU LEU A . n 
A 1 419 ASN 419 682 682 ASN ASN A . n 
A 1 420 ASP 420 683 683 ASP ASP A . n 
A 1 421 MET 421 684 684 MET MET A . n 
A 1 422 GLY 422 685 685 GLY GLY A . n 
A 1 423 LYS 423 686 686 LYS LYS A . n 
A 1 424 VAL 424 687 687 VAL VAL A . n 
A 1 425 ARG 425 688 688 ARG ARG A . n 
A 1 426 LYS 426 689 689 LYS LYS A . n 
A 1 427 ASP 427 690 690 ASP ASP A . n 
A 1 428 ILE 428 691 691 ILE ILE A . n 
A 1 429 GLN 429 692 692 GLN GLN A . n 
A 1 430 GLN 430 693 693 GLN GLN A . n 
A 1 431 TRP 431 694 694 TRP TRP A . n 
A 1 432 GLU 432 695 695 GLU GLU A . n 
A 1 433 PRO 433 696 696 PRO PRO A . n 
A 1 434 SER 434 697 697 SER SER A . n 
A 1 435 ARG 435 698 698 ARG ARG A . n 
A 1 436 GLY 436 699 699 GLY GLY A . n 
A 1 437 TRP 437 700 700 TRP TRP A . n 
A 1 438 ASN 438 701 701 ASN ASN A . n 
A 1 439 ASP 439 702 702 ASP ASP A . n 
A 1 440 TRP 440 703 703 TRP TRP A . n 
A 1 441 THR 441 704 704 THR THR A . n 
A 1 442 GLN 442 705 705 GLN GLN A . n 
A 1 443 VAL 443 706 706 VAL VAL A . n 
A 1 444 PRO 444 707 707 PRO PRO A . n 
A 1 445 PHE 445 708 708 PHE PHE A . n 
A 1 446 CYS 446 709 709 CYS CYS A . n 
A 1 447 SER 447 710 710 SER SER A . n 
A 1 448 HIS 448 711 711 HIS HIS A . n 
A 1 449 HIS 449 712 712 HIS HIS A . n 
A 1 450 PHE 450 713 713 PHE PHE A . n 
A 1 451 HIS 451 714 714 HIS HIS A . n 
A 1 452 GLU 452 715 715 GLU GLU A . n 
A 1 453 LEU 453 716 716 LEU LEU A . n 
A 1 454 ILE 454 717 717 ILE ILE A . n 
A 1 455 MET 455 718 718 MET MET A . n 
A 1 456 LYS 456 719 719 LYS LYS A . n 
A 1 457 ASP 457 720 720 ASP ASP A . n 
A 1 458 GLY 458 721 721 GLY GLY A . n 
A 1 459 ARG 459 722 722 ARG ARG A . n 
A 1 460 VAL 460 723 723 VAL VAL A . n 
A 1 461 LEU 461 724 724 LEU LEU A . n 
A 1 462 VAL 462 725 725 VAL VAL A . n 
A 1 463 VAL 463 726 726 VAL VAL A . n 
A 1 464 PRO 464 727 727 PRO PRO A . n 
A 1 465 CYS 465 728 728 CYS CYS A . n 
A 1 466 ARG 466 729 729 ARG ARG A . n 
A 1 467 ASN 467 730 730 ASN ASN A . n 
A 1 468 GLN 468 731 731 GLN GLN A . n 
A 1 469 ASP 469 732 732 ASP ASP A . n 
A 1 470 GLU 470 733 733 GLU GLU A . n 
A 1 471 LEU 471 734 734 LEU LEU A . n 
A 1 472 ILE 472 735 735 ILE ILE A . n 
A 1 473 GLY 473 736 736 GLY GLY A . n 
A 1 474 ARG 474 737 737 ARG ARG A . n 
A 1 475 ALA 475 738 738 ALA ALA A . n 
A 1 476 ARG 476 739 739 ARG ARG A . n 
A 1 477 ILE 477 740 740 ILE ILE A . n 
A 1 478 SER 478 741 741 SER SER A . n 
A 1 479 GLN 479 742 742 GLN GLN A . n 
A 1 480 GLY 480 743 743 GLY GLY A . n 
A 1 481 ALA 481 744 744 ALA ALA A . n 
A 1 482 GLY 482 745 745 GLY GLY A . n 
A 1 483 TRP 483 746 746 TRP TRP A . n 
A 1 484 SER 484 747 747 SER SER A . n 
A 1 485 LEU 485 748 748 LEU LEU A . n 
A 1 486 ARG 486 749 749 ARG ARG A . n 
A 1 487 GLU 487 750 750 GLU GLU A . n 
A 1 488 THR 488 751 751 THR THR A . n 
A 1 489 ALA 489 752 752 ALA ALA A . n 
A 1 490 CYS 490 753 753 CYS CYS A . n 
A 1 491 LEU 491 754 754 LEU LEU A . n 
A 1 492 GLY 492 755 755 GLY GLY A . n 
A 1 493 LYS 493 756 756 LYS LYS A . n 
A 1 494 SER 494 757 757 SER SER A . n 
A 1 495 TYR 495 758 758 TYR TYR A . n 
A 1 496 ALA 496 759 759 ALA ALA A . n 
A 1 497 GLN 497 760 760 GLN GLN A . n 
A 1 498 MET 498 761 761 MET MET A . n 
A 1 499 TRP 499 762 762 TRP TRP A . n 
A 1 500 SER 500 763 763 SER SER A . n 
A 1 501 LEU 501 764 764 LEU LEU A . n 
A 1 502 MET 502 765 765 MET MET A . n 
A 1 503 TYR 503 766 766 TYR TYR A . n 
A 1 504 PHE 504 767 767 PHE PHE A . n 
A 1 505 HIS 505 768 768 HIS HIS A . n 
A 1 506 ARG 506 769 769 ARG ARG A . n 
A 1 507 ARG 507 770 770 ARG ARG A . n 
A 1 508 ASP 508 771 771 ASP ASP A . n 
A 1 509 LEU 509 772 772 LEU LEU A . n 
A 1 510 ARG 510 773 773 ARG ARG A . n 
A 1 511 LEU 511 774 774 LEU LEU A . n 
A 1 512 ALA 512 775 775 ALA ALA A . n 
A 1 513 ALA 513 776 776 ALA ALA A . n 
A 1 514 ASN 514 777 777 ASN ASN A . n 
A 1 515 ALA 515 778 778 ALA ALA A . n 
A 1 516 ILE 516 779 779 ILE ILE A . n 
A 1 517 CYS 517 780 780 CYS CYS A . n 
A 1 518 SER 518 781 781 SER SER A . n 
A 1 519 ALA 519 782 782 ALA ALA A . n 
A 1 520 VAL 520 783 783 VAL VAL A . n 
A 1 521 PRO 521 784 784 PRO PRO A . n 
A 1 522 SER 522 785 785 SER SER A . n 
A 1 523 HIS 523 786 786 HIS HIS A . n 
A 1 524 TRP 524 787 787 TRP TRP A . n 
A 1 525 VAL 525 788 788 VAL VAL A . n 
A 1 526 PRO 526 789 789 PRO PRO A . n 
A 1 527 THR 527 790 790 THR THR A . n 
A 1 528 SER 528 791 791 SER SER A . n 
A 1 529 ARG 529 792 792 ARG ARG A . n 
A 1 530 THR 530 793 793 THR THR A . n 
A 1 531 THR 531 794 ?   ?   ?   A . n 
A 1 532 TRP 532 795 ?   ?   ?   A . n 
A 1 533 SER 533 796 ?   ?   ?   A . n 
A 1 534 ILE 534 797 ?   ?   ?   A . n 
A 1 535 HIS 535 798 ?   ?   ?   A . n 
A 1 536 ALA 536 799 799 ALA ALA A . n 
A 1 537 THR 537 800 800 THR THR A . n 
A 1 538 HIS 538 801 801 HIS HIS A . n 
A 1 539 GLU 539 802 802 GLU GLU A . n 
A 1 540 TRP 540 803 803 TRP TRP A . n 
A 1 541 MET 541 804 804 MET MET A . n 
A 1 542 THR 542 805 805 THR THR A . n 
A 1 543 THR 543 806 806 THR THR A . n 
A 1 544 GLU 544 807 807 GLU GLU A . n 
A 1 545 ASP 545 808 808 ASP ASP A . n 
A 1 546 MET 546 809 809 MET MET A . n 
A 1 547 LEU 547 810 810 LEU LEU A . n 
A 1 548 THR 548 811 811 THR THR A . n 
A 1 549 VAL 549 812 812 VAL VAL A . n 
A 1 550 TRP 550 813 813 TRP TRP A . n 
A 1 551 ASN 551 814 814 ASN ASN A . n 
A 1 552 ARG 552 815 815 ARG ARG A . n 
A 1 553 VAL 553 816 816 VAL VAL A . n 
A 1 554 TRP 554 817 817 TRP TRP A . n 
A 1 555 ILE 555 818 818 ILE ILE A . n 
A 1 556 GLN 556 819 819 GLN GLN A . n 
A 1 557 GLU 557 820 820 GLU GLU A . n 
A 1 558 ASN 558 821 821 ASN ASN A . n 
A 1 559 PRO 559 822 822 PRO PRO A . n 
A 1 560 TRP 560 823 823 TRP TRP A . n 
A 1 561 MET 561 824 824 MET MET A . n 
A 1 562 GLU 562 825 825 GLU GLU A . n 
A 1 563 ASP 563 826 826 ASP ASP A . n 
A 1 564 LYS 564 827 827 LYS LYS A . n 
A 1 565 THR 565 828 828 THR THR A . n 
A 1 566 PRO 566 829 829 PRO PRO A . n 
A 1 567 VAL 567 830 830 VAL VAL A . n 
A 1 568 GLU 568 831 831 GLU GLU A . n 
A 1 569 SER 569 832 832 SER SER A . n 
A 1 570 TRP 570 833 833 TRP TRP A . n 
A 1 571 GLU 571 834 834 GLU GLU A . n 
A 1 572 GLU 572 835 835 GLU GLU A . n 
A 1 573 ILE 573 836 836 ILE ILE A . n 
A 1 574 PRO 574 837 837 PRO PRO A . n 
A 1 575 TYR 575 838 838 TYR TYR A . n 
A 1 576 LEU 576 839 839 LEU LEU A . n 
A 1 577 GLY 577 840 840 GLY GLY A . n 
A 1 578 LYS 578 841 841 LYS LYS A . n 
A 1 579 ARG 579 842 842 ARG ARG A . n 
A 1 580 GLU 580 843 843 GLU GLU A . n 
A 1 581 ASP 581 844 844 ASP ASP A . n 
A 1 582 GLN 582 845 845 GLN GLN A . n 
A 1 583 TRP 583 846 846 TRP TRP A . n 
A 1 584 CYS 584 847 847 CYS CYS A . n 
A 1 585 GLY 585 848 848 GLY GLY A . n 
A 1 586 SER 586 849 849 SER SER A . n 
A 1 587 LEU 587 850 850 LEU LEU A . n 
A 1 588 ILE 588 851 851 ILE ILE A . n 
A 1 589 GLY 589 852 852 GLY GLY A . n 
A 1 590 LEU 590 853 853 LEU LEU A . n 
A 1 591 THR 591 854 854 THR THR A . n 
A 1 592 SER 592 855 855 SER SER A . n 
A 1 593 ARG 593 856 856 ARG ARG A . n 
A 1 594 ALA 594 857 857 ALA ALA A . n 
A 1 595 THR 595 858 858 THR THR A . n 
A 1 596 TRP 596 859 859 TRP TRP A . n 
A 1 597 ALA 597 860 860 ALA ALA A . n 
A 1 598 LYS 598 861 861 LYS LYS A . n 
A 1 599 ASN 599 862 862 ASN ASN A . n 
A 1 600 ILE 600 863 863 ILE ILE A . n 
A 1 601 GLN 601 864 864 GLN GLN A . n 
A 1 602 THR 602 865 865 THR THR A . n 
A 1 603 ALA 603 866 866 ALA ALA A . n 
A 1 604 ILE 604 867 867 ILE ILE A . n 
A 1 605 ASN 605 868 868 ASN ASN A . n 
A 1 606 GLN 606 869 869 GLN GLN A . n 
A 1 607 VAL 607 870 870 VAL VAL A . n 
A 1 608 ARG 608 871 871 ARG ARG A . n 
A 1 609 SER 609 872 872 SER SER A . n 
A 1 610 LEU 610 873 873 LEU LEU A . n 
A 1 611 ILE 611 874 874 ILE ILE A . n 
A 1 612 GLY 612 875 875 GLY GLY A . n 
A 1 613 ASN 613 876 876 ASN ASN A . n 
A 1 614 GLU 614 877 877 GLU GLU A . n 
A 1 615 GLU 615 878 878 GLU GLU A . n 
A 1 616 TYR 616 879 879 TYR TYR A . n 
A 1 617 THR 617 880 880 THR THR A . n 
A 1 618 ASP 618 881 881 ASP ASP A . n 
A 1 619 TYR 619 882 882 TYR TYR A . n 
A 1 620 MET 620 883 883 MET MET A . n 
A 1 621 PRO 621 884 884 PRO PRO A . n 
A 1 622 SER 622 885 885 SER SER A . n 
A 1 623 MET 623 886 886 MET MET A . n 
A 1 624 LYS 624 887 887 LYS LYS A . n 
A 1 625 ARG 625 888 888 ARG ARG A . n 
A 1 626 PHE 626 889 889 PHE PHE A . n 
A 1 627 ARG 627 890 890 ARG ARG A . n 
A 1 628 ARG 628 891 891 ARG ARG A . n 
A 1 629 GLU 629 892 ?   ?   ?   A . n 
A 1 630 GLU 630 893 ?   ?   ?   A . n 
A 1 631 GLU 631 894 ?   ?   ?   A . n 
A 1 632 GLU 632 895 ?   ?   ?   A . n 
A 1 633 ALA 633 896 ?   ?   ?   A . n 
A 1 634 GLY 634 897 ?   ?   ?   A . n 
A 1 635 VAL 635 898 ?   ?   ?   A . n 
A 1 636 LEU 636 899 ?   ?   ?   A . n 
A 1 637 TRP 637 900 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        B1A 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   B1A 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 ZN  1   1001 1001 ZN  ZN  A . 
C 2 ZN  1   1002 1002 ZN  ZN  A . 
D 3 MES 1   1003 1004 MES MES A . 
E 4 DMS 1   1004 1530 DMS DMS A . 
F 4 DMS 1   1005 1601 DMS DMS A . 
G 4 DMS 1   1006 1602 DMS DMS A . 
H 5 PEG 1   1007 1603 PEG PEG A . 
I 6 PO4 1   1008 1604 PO4 PO4 A . 
J 6 PO4 1   1009 1606 PO4 PO4 A . 
K 5 PEG 1   1010 1607 PEG PEG A . 
L 7 B1A 1   1011 1707 B1A LIG A . 
M 8 CL  1   1012 1    CL  CL  A . 
N 9 HOH 1   1101 434  HOH HOH A . 
N 9 HOH 2   1102 47   HOH HOH A . 
N 9 HOH 3   1103 267  HOH HOH A . 
N 9 HOH 4   1104 259  HOH HOH A . 
N 9 HOH 5   1105 11   HOH HOH A . 
N 9 HOH 6   1106 58   HOH HOH A . 
N 9 HOH 7   1107 193  HOH HOH A . 
N 9 HOH 8   1108 35   HOH HOH A . 
N 9 HOH 9   1109 191  HOH HOH A . 
N 9 HOH 10  1110 189  HOH HOH A . 
N 9 HOH 11  1111 60   HOH HOH A . 
N 9 HOH 12  1112 216  HOH HOH A . 
N 9 HOH 13  1113 250  HOH HOH A . 
N 9 HOH 14  1114 175  HOH HOH A . 
N 9 HOH 15  1115 273  HOH HOH A . 
N 9 HOH 16  1116 230  HOH HOH A . 
N 9 HOH 17  1117 204  HOH HOH A . 
N 9 HOH 18  1118 45   HOH HOH A . 
N 9 HOH 19  1119 226  HOH HOH A . 
N 9 HOH 20  1120 183  HOH HOH A . 
N 9 HOH 21  1121 227  HOH HOH A . 
N 9 HOH 22  1122 152  HOH HOH A . 
N 9 HOH 23  1123 206  HOH HOH A . 
N 9 HOH 24  1124 177  HOH HOH A . 
N 9 HOH 25  1125 281  HOH HOH A . 
N 9 HOH 26  1126 209  HOH HOH A . 
N 9 HOH 27  1127 420  HOH HOH A . 
N 9 HOH 28  1128 345  HOH HOH A . 
N 9 HOH 29  1129 148  HOH HOH A . 
N 9 HOH 30  1130 348  HOH HOH A . 
N 9 HOH 31  1131 195  HOH HOH A . 
N 9 HOH 32  1132 464  HOH HOH A . 
N 9 HOH 33  1133 52   HOH HOH A . 
N 9 HOH 34  1134 178  HOH HOH A . 
N 9 HOH 35  1135 166  HOH HOH A . 
N 9 HOH 36  1136 239  HOH HOH A . 
N 9 HOH 37  1137 256  HOH HOH A . 
N 9 HOH 38  1138 288  HOH HOH A . 
N 9 HOH 39  1139 180  HOH HOH A . 
N 9 HOH 40  1140 104  HOH HOH A . 
N 9 HOH 41  1141 77   HOH HOH A . 
N 9 HOH 42  1142 120  HOH HOH A . 
N 9 HOH 43  1143 408  HOH HOH A . 
N 9 HOH 44  1144 251  HOH HOH A . 
N 9 HOH 45  1145 34   HOH HOH A . 
N 9 HOH 46  1146 7    HOH HOH A . 
N 9 HOH 47  1147 3    HOH HOH A . 
N 9 HOH 48  1148 108  HOH HOH A . 
N 9 HOH 49  1149 254  HOH HOH A . 
N 9 HOH 50  1150 258  HOH HOH A . 
N 9 HOH 51  1151 291  HOH HOH A . 
N 9 HOH 52  1152 176  HOH HOH A . 
N 9 HOH 53  1153 187  HOH HOH A . 
N 9 HOH 54  1154 190  HOH HOH A . 
N 9 HOH 55  1155 222  HOH HOH A . 
N 9 HOH 56  1156 185  HOH HOH A . 
N 9 HOH 57  1157 214  HOH HOH A . 
N 9 HOH 58  1158 25   HOH HOH A . 
N 9 HOH 59  1159 220  HOH HOH A . 
N 9 HOH 60  1160 392  HOH HOH A . 
N 9 HOH 61  1161 242  HOH HOH A . 
N 9 HOH 62  1162 312  HOH HOH A . 
N 9 HOH 63  1163 363  HOH HOH A . 
N 9 HOH 64  1164 236  HOH HOH A . 
N 9 HOH 65  1165 247  HOH HOH A . 
N 9 HOH 66  1166 127  HOH HOH A . 
N 9 HOH 67  1167 280  HOH HOH A . 
N 9 HOH 68  1168 199  HOH HOH A . 
N 9 HOH 69  1169 4    HOH HOH A . 
N 9 HOH 70  1170 319  HOH HOH A . 
N 9 HOH 71  1171 188  HOH HOH A . 
N 9 HOH 72  1172 184  HOH HOH A . 
N 9 HOH 73  1173 170  HOH HOH A . 
N 9 HOH 74  1174 262  HOH HOH A . 
N 9 HOH 75  1175 215  HOH HOH A . 
N 9 HOH 76  1176 272  HOH HOH A . 
N 9 HOH 77  1177 212  HOH HOH A . 
N 9 HOH 78  1178 458  HOH HOH A . 
N 9 HOH 79  1179 217  HOH HOH A . 
N 9 HOH 80  1180 292  HOH HOH A . 
N 9 HOH 81  1181 197  HOH HOH A . 
N 9 HOH 82  1182 296  HOH HOH A . 
N 9 HOH 83  1183 213  HOH HOH A . 
N 9 HOH 84  1184 186  HOH HOH A . 
N 9 HOH 85  1185 315  HOH HOH A . 
N 9 HOH 86  1186 317  HOH HOH A . 
N 9 HOH 87  1187 234  HOH HOH A . 
N 9 HOH 88  1188 264  HOH HOH A . 
N 9 HOH 89  1189 202  HOH HOH A . 
N 9 HOH 90  1190 92   HOH HOH A . 
N 9 HOH 91  1191 327  HOH HOH A . 
N 9 HOH 92  1192 300  HOH HOH A . 
N 9 HOH 93  1193 243  HOH HOH A . 
N 9 HOH 94  1194 30   HOH HOH A . 
N 9 HOH 95  1195 245  HOH HOH A . 
N 9 HOH 96  1196 396  HOH HOH A . 
N 9 HOH 97  1197 252  HOH HOH A . 
N 9 HOH 98  1198 203  HOH HOH A . 
N 9 HOH 99  1199 196  HOH HOH A . 
N 9 HOH 100 1200 207  HOH HOH A . 
N 9 HOH 101 1201 253  HOH HOH A . 
N 9 HOH 102 1202 238  HOH HOH A . 
N 9 HOH 103 1203 205  HOH HOH A . 
N 9 HOH 104 1204 307  HOH HOH A . 
N 9 HOH 105 1205 265  HOH HOH A . 
N 9 HOH 106 1206 274  HOH HOH A . 
N 9 HOH 107 1207 198  HOH HOH A . 
N 9 HOH 108 1208 210  HOH HOH A . 
N 9 HOH 109 1209 164  HOH HOH A . 
N 9 HOH 110 1210 303  HOH HOH A . 
N 9 HOH 111 1211 232  HOH HOH A . 
N 9 HOH 112 1212 89   HOH HOH A . 
N 9 HOH 113 1213 308  HOH HOH A . 
N 9 HOH 114 1214 240  HOH HOH A . 
N 9 HOH 115 1215 309  HOH HOH A . 
N 9 HOH 116 1216 201  HOH HOH A . 
N 9 HOH 117 1217 48   HOH HOH A . 
N 9 HOH 118 1218 37   HOH HOH A . 
N 9 HOH 119 1219 223  HOH HOH A . 
N 9 HOH 120 1220 46   HOH HOH A . 
N 9 HOH 121 1221 2    HOH HOH A . 
N 9 HOH 122 1222 6    HOH HOH A . 
N 9 HOH 123 1223 358  HOH HOH A . 
N 9 HOH 124 1224 260  HOH HOH A . 
N 9 HOH 125 1225 342  HOH HOH A . 
N 9 HOH 126 1226 211  HOH HOH A . 
N 9 HOH 127 1227 231  HOH HOH A . 
N 9 HOH 128 1228 125  HOH HOH A . 
N 9 HOH 129 1229 268  HOH HOH A . 
N 9 HOH 130 1230 218  HOH HOH A . 
N 9 HOH 131 1231 289  HOH HOH A . 
N 9 HOH 132 1232 333  HOH HOH A . 
N 9 HOH 133 1233 16   HOH HOH A . 
N 9 HOH 134 1234 151  HOH HOH A . 
N 9 HOH 135 1235 5    HOH HOH A . 
N 9 HOH 136 1236 96   HOH HOH A . 
N 9 HOH 137 1237 277  HOH HOH A . 
N 9 HOH 138 1238 182  HOH HOH A . 
N 9 HOH 139 1239 174  HOH HOH A . 
N 9 HOH 140 1240 328  HOH HOH A . 
N 9 HOH 141 1241 244  HOH HOH A . 
N 9 HOH 142 1242 69   HOH HOH A . 
N 9 HOH 143 1243 266  HOH HOH A . 
N 9 HOH 144 1244 221  HOH HOH A . 
N 9 HOH 145 1245 194  HOH HOH A . 
N 9 HOH 146 1246 150  HOH HOH A . 
N 9 HOH 147 1247 325  HOH HOH A . 
N 9 HOH 148 1248 361  HOH HOH A . 
N 9 HOH 149 1249 237  HOH HOH A . 
N 9 HOH 150 1250 224  HOH HOH A . 
N 9 HOH 151 1251 86   HOH HOH A . 
N 9 HOH 152 1252 257  HOH HOH A . 
N 9 HOH 153 1253 31   HOH HOH A . 
N 9 HOH 154 1254 294  HOH HOH A . 
N 9 HOH 155 1255 365  HOH HOH A . 
N 9 HOH 156 1256 306  HOH HOH A . 
N 9 HOH 157 1257 302  HOH HOH A . 
N 9 HOH 158 1258 117  HOH HOH A . 
N 9 HOH 159 1259 225  HOH HOH A . 
N 9 HOH 160 1260 346  HOH HOH A . 
N 9 HOH 161 1261 293  HOH HOH A . 
N 9 HOH 162 1262 320  HOH HOH A . 
N 9 HOH 163 1263 321  HOH HOH A . 
N 9 HOH 164 1264 322  HOH HOH A . 
N 9 HOH 165 1265 278  HOH HOH A . 
N 9 HOH 166 1266 323  HOH HOH A . 
N 9 HOH 167 1267 467  HOH HOH A . 
N 9 HOH 168 1268 143  HOH HOH A . 
N 9 HOH 169 1269 269  HOH HOH A . 
N 9 HOH 170 1270 233  HOH HOH A . 
N 9 HOH 171 1271 285  HOH HOH A . 
N 9 HOH 172 1272 219  HOH HOH A . 
N 9 HOH 173 1273 27   HOH HOH A . 
N 9 HOH 174 1274 50   HOH HOH A . 
N 9 HOH 175 1275 343  HOH HOH A . 
N 9 HOH 176 1276 318  HOH HOH A . 
N 9 HOH 177 1277 304  HOH HOH A . 
N 9 HOH 178 1278 368  HOH HOH A . 
N 9 HOH 179 1279 290  HOH HOH A . 
N 9 HOH 180 1280 276  HOH HOH A . 
N 9 HOH 181 1281 313  HOH HOH A . 
N 9 HOH 182 1282 261  HOH HOH A . 
N 9 HOH 183 1283 270  HOH HOH A . 
N 9 HOH 184 1284 459  HOH HOH A . 
N 9 HOH 185 1285 98   HOH HOH A . 
N 9 HOH 186 1286 67   HOH HOH A . 
N 9 HOH 187 1287 19   HOH HOH A . 
N 9 HOH 188 1288 395  HOH HOH A . 
N 9 HOH 189 1289 349  HOH HOH A . 
N 9 HOH 190 1290 39   HOH HOH A . 
N 9 HOH 191 1291 241  HOH HOH A . 
N 9 HOH 192 1292 339  HOH HOH A . 
N 9 HOH 193 1293 381  HOH HOH A . 
N 9 HOH 194 1294 83   HOH HOH A . 
N 9 HOH 195 1295 70   HOH HOH A . 
N 9 HOH 196 1296 423  HOH HOH A . 
N 9 HOH 197 1297 311  HOH HOH A . 
N 9 HOH 198 1298 298  HOH HOH A . 
N 9 HOH 199 1299 353  HOH HOH A . 
N 9 HOH 200 1300 372  HOH HOH A . 
N 9 HOH 201 1301 356  HOH HOH A . 
N 9 HOH 202 1302 284  HOH HOH A . 
N 9 HOH 203 1303 235  HOH HOH A . 
N 9 HOH 204 1304 22   HOH HOH A . 
N 9 HOH 205 1305 275  HOH HOH A . 
N 9 HOH 206 1306 42   HOH HOH A . 
N 9 HOH 207 1307 366  HOH HOH A . 
N 9 HOH 208 1308 462  HOH HOH A . 
N 9 HOH 209 1309 15   HOH HOH A . 
N 9 HOH 210 1310 364  HOH HOH A . 
N 9 HOH 211 1311 331  HOH HOH A . 
N 9 HOH 212 1312 357  HOH HOH A . 
N 9 HOH 213 1313 355  HOH HOH A . 
N 9 HOH 214 1314 246  HOH HOH A . 
N 9 HOH 215 1315 140  HOH HOH A . 
N 9 HOH 216 1316 33   HOH HOH A . 
N 9 HOH 217 1317 335  HOH HOH A . 
N 9 HOH 218 1318 136  HOH HOH A . 
N 9 HOH 219 1319 389  HOH HOH A . 
N 9 HOH 220 1320 369  HOH HOH A . 
N 9 HOH 221 1321 375  HOH HOH A . 
N 9 HOH 222 1322 26   HOH HOH A . 
N 9 HOH 223 1323 248  HOH HOH A . 
N 9 HOH 224 1324 351  HOH HOH A . 
N 9 HOH 225 1325 380  HOH HOH A . 
N 9 HOH 226 1326 271  HOH HOH A . 
N 9 HOH 227 1327 228  HOH HOH A . 
N 9 HOH 228 1328 82   HOH HOH A . 
N 9 HOH 229 1329 386  HOH HOH A . 
N 9 HOH 230 1330 378  HOH HOH A . 
N 9 HOH 231 1331 32   HOH HOH A . 
N 9 HOH 232 1332 360  HOH HOH A . 
N 9 HOH 233 1333 110  HOH HOH A . 
N 9 HOH 234 1334 350  HOH HOH A . 
N 9 HOH 235 1335 371  HOH HOH A . 
N 9 HOH 236 1336 38   HOH HOH A . 
N 9 HOH 237 1337 179  HOH HOH A . 
N 9 HOH 238 1338 330  HOH HOH A . 
N 9 HOH 239 1339 377  HOH HOH A . 
N 9 HOH 240 1340 24   HOH HOH A . 
N 9 HOH 241 1341 466  HOH HOH A . 
N 9 HOH 242 1342 305  HOH HOH A . 
N 9 HOH 243 1343 314  HOH HOH A . 
N 9 HOH 244 1344 282  HOH HOH A . 
N 9 HOH 245 1345 316  HOH HOH A . 
N 9 HOH 246 1346 402  HOH HOH A . 
N 9 HOH 247 1347 352  HOH HOH A . 
N 9 HOH 248 1348 340  HOH HOH A . 
N 9 HOH 249 1349 286  HOH HOH A . 
N 9 HOH 250 1350 297  HOH HOH A . 
N 9 HOH 251 1351 255  HOH HOH A . 
N 9 HOH 252 1352 376  HOH HOH A . 
N 9 HOH 253 1353 20   HOH HOH A . 
N 9 HOH 254 1354 57   HOH HOH A . 
N 9 HOH 255 1355 326  HOH HOH A . 
N 9 HOH 256 1356 388  HOH HOH A . 
N 9 HOH 257 1357 347  HOH HOH A . 
N 9 HOH 258 1358 383  HOH HOH A . 
N 9 HOH 259 1359 14   HOH HOH A . 
N 9 HOH 260 1360 329  HOH HOH A . 
N 9 HOH 261 1361 374  HOH HOH A . 
N 9 HOH 262 1362 310  HOH HOH A . 
N 9 HOH 263 1363 384  HOH HOH A . 
N 9 HOH 264 1364 403  HOH HOH A . 
N 9 HOH 265 1365 263  HOH HOH A . 
N 9 HOH 266 1366 399  HOH HOH A . 
N 9 HOH 267 1367 142  HOH HOH A . 
N 9 HOH 268 1368 1    HOH HOH A . 
N 9 HOH 269 1369 394  HOH HOH A . 
N 9 HOH 270 1370 367  HOH HOH A . 
N 9 HOH 271 1371 344  HOH HOH A . 
N 9 HOH 272 1372 354  HOH HOH A . 
N 9 HOH 273 1373 36   HOH HOH A . 
N 9 HOH 274 1374 299  HOH HOH A . 
N 9 HOH 275 1375 100  HOH HOH A . 
N 9 HOH 276 1376 109  HOH HOH A . 
N 9 HOH 277 1377 56   HOH HOH A . 
N 9 HOH 278 1378 444  HOH HOH A . 
N 9 HOH 279 1379 334  HOH HOH A . 
N 9 HOH 280 1380 391  HOH HOH A . 
N 9 HOH 281 1381 454  HOH HOH A . 
N 9 HOH 282 1382 405  HOH HOH A . 
N 9 HOH 283 1383 401  HOH HOH A . 
N 9 HOH 284 1384 29   HOH HOH A . 
N 9 HOH 285 1385 387  HOH HOH A . 
N 9 HOH 286 1386 338  HOH HOH A . 
N 9 HOH 287 1387 134  HOH HOH A . 
N 9 HOH 288 1388 422  HOH HOH A . 
N 9 HOH 289 1389 393  HOH HOH A . 
N 9 HOH 290 1390 404  HOH HOH A . 
N 9 HOH 291 1391 406  HOH HOH A . 
N 9 HOH 292 1392 379  HOH HOH A . 
N 9 HOH 293 1393 390  HOH HOH A . 
N 9 HOH 294 1394 118  HOH HOH A . 
N 9 HOH 295 1395 106  HOH HOH A . 
N 9 HOH 296 1396 415  HOH HOH A . 
N 9 HOH 297 1397 81   HOH HOH A . 
N 9 HOH 298 1398 410  HOH HOH A . 
N 9 HOH 299 1399 138  HOH HOH A . 
N 9 HOH 300 1400 359  HOH HOH A . 
N 9 HOH 301 1401 283  HOH HOH A . 
N 9 HOH 302 1402 418  HOH HOH A . 
N 9 HOH 303 1403 18   HOH HOH A . 
N 9 HOH 304 1404 40   HOH HOH A . 
N 9 HOH 305 1405 411  HOH HOH A . 
N 9 HOH 306 1406 114  HOH HOH A . 
N 9 HOH 307 1407 421  HOH HOH A . 
N 9 HOH 308 1408 91   HOH HOH A . 
N 9 HOH 309 1409 88   HOH HOH A . 
N 9 HOH 310 1410 461  HOH HOH A . 
N 9 HOH 311 1411 65   HOH HOH A . 
N 9 HOH 312 1412 287  HOH HOH A . 
N 9 HOH 313 1413 412  HOH HOH A . 
N 9 HOH 314 1414 332  HOH HOH A . 
N 9 HOH 315 1415 132  HOH HOH A . 
N 9 HOH 316 1416 80   HOH HOH A . 
N 9 HOH 317 1417 23   HOH HOH A . 
N 9 HOH 318 1418 181  HOH HOH A . 
N 9 HOH 319 1419 62   HOH HOH A . 
N 9 HOH 320 1420 146  HOH HOH A . 
N 9 HOH 321 1421 324  HOH HOH A . 
N 9 HOH 322 1422 417  HOH HOH A . 
N 9 HOH 323 1423 13   HOH HOH A . 
N 9 HOH 324 1424 43   HOH HOH A . 
N 9 HOH 325 1425 28   HOH HOH A . 
N 9 HOH 326 1426 99   HOH HOH A . 
N 9 HOH 327 1427 409  HOH HOH A . 
N 9 HOH 328 1428 424  HOH HOH A . 
N 9 HOH 329 1429 159  HOH HOH A . 
N 9 HOH 330 1430 54   HOH HOH A . 
N 9 HOH 331 1431 59   HOH HOH A . 
N 9 HOH 332 1432 123  HOH HOH A . 
N 9 HOH 333 1433 430  HOH HOH A . 
N 9 HOH 334 1434 41   HOH HOH A . 
N 9 HOH 335 1435 398  HOH HOH A . 
N 9 HOH 336 1436 137  HOH HOH A . 
N 9 HOH 337 1437 200  HOH HOH A . 
N 9 HOH 338 1438 433  HOH HOH A . 
N 9 HOH 339 1439 102  HOH HOH A . 
N 9 HOH 340 1440 44   HOH HOH A . 
N 9 HOH 341 1441 428  HOH HOH A . 
N 9 HOH 342 1442 429  HOH HOH A . 
N 9 HOH 343 1443 414  HOH HOH A . 
N 9 HOH 344 1444 431  HOH HOH A . 
N 9 HOH 345 1445 439  HOH HOH A . 
N 9 HOH 346 1446 12   HOH HOH A . 
N 9 HOH 347 1447 397  HOH HOH A . 
N 9 HOH 348 1448 385  HOH HOH A . 
N 9 HOH 349 1449 55   HOH HOH A . 
N 9 HOH 350 1450 63   HOH HOH A . 
N 9 HOH 351 1451 437  HOH HOH A . 
N 9 HOH 352 1452 425  HOH HOH A . 
N 9 HOH 353 1453 61   HOH HOH A . 
N 9 HOH 354 1454 53   HOH HOH A . 
N 9 HOH 355 1455 94   HOH HOH A . 
N 9 HOH 356 1456 426  HOH HOH A . 
N 9 HOH 357 1457 71   HOH HOH A . 
N 9 HOH 358 1458 463  HOH HOH A . 
N 9 HOH 359 1459 432  HOH HOH A . 
N 9 HOH 360 1460 103  HOH HOH A . 
N 9 HOH 361 1461 438  HOH HOH A . 
N 9 HOH 362 1462 435  HOH HOH A . 
N 9 HOH 363 1463 8    HOH HOH A . 
N 9 HOH 364 1464 51   HOH HOH A . 
N 9 HOH 365 1465 115  HOH HOH A . 
N 9 HOH 366 1466 157  HOH HOH A . 
N 9 HOH 367 1467 74   HOH HOH A . 
N 9 HOH 368 1468 442  HOH HOH A . 
N 9 HOH 369 1469 445  HOH HOH A . 
N 9 HOH 370 1470 121  HOH HOH A . 
N 9 HOH 371 1471 449  HOH HOH A . 
N 9 HOH 372 1472 436  HOH HOH A . 
N 9 HOH 373 1473 172  HOH HOH A . 
N 9 HOH 374 1474 447  HOH HOH A . 
N 9 HOH 375 1475 64   HOH HOH A . 
N 9 HOH 376 1476 468  HOH HOH A . 
N 9 HOH 377 1477 441  HOH HOH A . 
N 9 HOH 378 1478 135  HOH HOH A . 
N 9 HOH 379 1479 168  HOH HOH A . 
N 9 HOH 380 1480 141  HOH HOH A . 
N 9 HOH 381 1481 440  HOH HOH A . 
N 9 HOH 382 1482 443  HOH HOH A . 
N 9 HOH 383 1483 448  HOH HOH A . 
N 9 HOH 384 1484 78   HOH HOH A . 
N 9 HOH 385 1485 122  HOH HOH A . 
N 9 HOH 386 1486 341  HOH HOH A . 
N 9 HOH 387 1487 9    HOH HOH A . 
N 9 HOH 388 1488 95   HOH HOH A . 
N 9 HOH 389 1489 455  HOH HOH A . 
N 9 HOH 390 1490 17   HOH HOH A . 
N 9 HOH 391 1491 73   HOH HOH A . 
N 9 HOH 392 1492 450  HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 A THR 344 ? CB  ? A THR 81 CB  
2 1 Y 1 A THR 344 ? OG1 ? A THR 81 OG1 
3 1 Y 1 A THR 344 ? CG2 ? A THR 81 CG2 
# 
loop_
_software.classification 
_software.name 
_software.version 
_software.citation_id 
_software.pdbx_ordinal 
refinement       REFMAC  5.8.0267 ? 1 
refinement       REFMAC5 .        ? 2 
'data scaling'   Aimless .        ? 3 
phasing          PHASER  .        ? 4 
'data reduction' XDS     .        ? 5 
# 
_cell.entry_id           7I2B 
_cell.length_a           82.476 
_cell.length_b           116.865 
_cell.length_c           148.174 
_cell.angle_alpha        90.00 
_cell.angle_beta         90.00 
_cell.angle_gamma        90.00 
_cell.Z_PDB              8 
_cell.pdbx_unique_axis   ? 
# 
_symmetry.entry_id                         7I2B 
_symmetry.space_group_name_H-M             'I 2 2 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                23 
# 
_exptl.entry_id          7I2B 
_exptl.method            'X-RAY DIFFRACTION' 
_exptl.crystals_number   1 
# 
_exptl_crystal.id                    1 
_exptl_crystal.density_meas          ? 
_exptl_crystal.density_Matthews      2.42 
_exptl_crystal.density_percent_sol   49.09 
_exptl_crystal.description           ? 
# 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.pH              6.5 
_exptl_crystal_grow.temp            293.15 
_exptl_crystal_grow.pdbx_details    '350 mM Magnesium chloride, 10% PEG 4000, 100 mM MES, pH 6.5' 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.pdbx_pH_range   ? 
# 
_diffrn.id                     1 
_diffrn.ambient_temp           100 
_diffrn.crystal_id             1 
_diffrn.ambient_temp_details   ? 
# 
_diffrn_detector.detector               PIXEL 
_diffrn_detector.type                   'DECTRIS EIGER2 XE 9M' 
_diffrn_detector.pdbx_collection_date   2023-08-09 
_diffrn_detector.diffrn_id              1 
_diffrn_detector.details                ? 
# 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.92124 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.diffrn_id                   1 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.type                        'DIAMOND BEAMLINE I04-1' 
_diffrn_source.pdbx_wavelength_list        0.92124 
_diffrn_source.pdbx_synchrotron_site       Diamond 
_diffrn_source.pdbx_synchrotron_beamline   I04-1 
_diffrn_source.pdbx_wavelength             ? 
# 
_reflns.entry_id                     7I2B 
_reflns.pdbx_diffrn_id               1 
_reflns.pdbx_ordinal                 1 
_reflns.d_resolution_low             45.89 
_reflns.d_resolution_high            1.60 
_reflns.number_obs                   94332 
_reflns.percent_possible_obs         100.0 
_reflns.pdbx_Rmerge_I_obs            0.110 
_reflns.pdbx_netI_over_sigmaI        11.8 
_reflns.pdbx_redundancy              13.0 
_reflns.pdbx_Rrim_I_all              0.115 
_reflns.pdbx_Rpim_I_all              0.031 
_reflns.pdbx_CC_half                 0.999 
_reflns.pdbx_number_measured_all     1223726 
_reflns.pdbx_chi_squared             0.47 
_reflns.observed_criterion_sigma_I   ? 
_reflns.observed_criterion_sigma_F   ? 
_reflns.number_all                   ? 
_reflns.pdbx_Rsym_value              ? 
_reflns.B_iso_Wilson_estimate        ? 
_reflns.pdbx_CC_star                 ? 
# 
_reflns_shell.pdbx_diffrn_id              1 
_reflns_shell.pdbx_ordinal                1 
_reflns_shell.d_res_high                  1.60 
_reflns_shell.d_res_low                   1.63 
_reflns_shell.number_measured_all         45081 
_reflns_shell.number_unique_obs           4599 
_reflns_shell.Rmerge_I_obs                4.546 
_reflns_shell.pdbx_chi_squared            0.17 
_reflns_shell.pdbx_redundancy             9.8 
_reflns_shell.percent_possible_obs        99.7 
_reflns_shell.pdbx_netI_over_sigmaI_obs   0.3 
_reflns_shell.pdbx_Rrim_I_all             4.799 
_reflns_shell.pdbx_Rpim_I_all             1.522 
_reflns_shell.pdbx_CC_half                0.345 
_reflns_shell.percent_possible_all        ? 
_reflns_shell.pdbx_Rsym_value             ? 
_reflns_shell.meanI_over_sigI_obs         ? 
_reflns_shell.number_measured_obs         ? 
_reflns_shell.number_unique_all           ? 
_reflns_shell.pdbx_CC_star                ? 
# 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.entry_id                                 7I2B 
_refine.pdbx_diffrn_id                           1 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     88823 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             45.89 
_refine.ls_d_res_high                            1.60 
_refine.ls_percent_reflns_obs                    99.16 
_refine.ls_R_factor_obs                          0.19442 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       0.19303 
_refine.ls_R_factor_R_free                       0.21962 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 5.1 
_refine.ls_number_reflns_R_free                  4756 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               0.966 
_refine.correlation_coeff_Fo_to_Fc_free          0.960 
_refine.B_iso_mean                               56.747 
_refine.aniso_B[1][1]                            -1.92 
_refine.aniso_B[2][2]                            0.57 
_refine.aniso_B[3][3]                            1.35 
_refine.aniso_B[1][2]                            -0.00 
_refine.aniso_B[1][3]                            0.00 
_refine.aniso_B[2][3]                            -0.00 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             1.20 
_refine.pdbx_solvent_ion_probe_radii             0.80 
_refine.pdbx_solvent_shrinkage_radii             0.80 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.details                                  'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_overall_ESU_R                       0.146 
_refine.pdbx_overall_ESU_R_Free                  0.122 
_refine.overall_SU_ML                            0.140 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             4.626 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         1 
_refine_hist.pdbx_number_atoms_protein        4680 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         68 
_refine_hist.number_atoms_solvent             392 
_refine_hist.number_atoms_total               5140 
_refine_hist.d_res_high                       1.60 
_refine_hist.d_res_low                        45.89 
# 
loop_
_refine_ls_restr.type 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.weight 
_refine_ls_restr.number 
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.pdbx_restraint_function 
r_bond_refined_d             0.007  0.015  ? 13450 'X-RAY DIFFRACTION' ? 
r_bond_other_d               0.001  0.015  ? 9323  'X-RAY DIFFRACTION' ? 
r_angle_refined_deg          1.396  1.646  ? 13404 'X-RAY DIFFRACTION' ? 
r_angle_other_deg            1.219  1.596  ? 21514 'X-RAY DIFFRACTION' ? 
r_dihedral_angle_1_deg       5.954  5.000  ? 1238  'X-RAY DIFFRACTION' ? 
r_dihedral_angle_2_deg       28.070 20.701 ? 585   'X-RAY DIFFRACTION' ? 
r_dihedral_angle_3_deg       16.544 15.000 ? 1848  'X-RAY DIFFRACTION' ? 
r_dihedral_angle_4_deg       16.889 15.000 ? 101   'X-RAY DIFFRACTION' ? 
r_chiral_restr               0.063  0.200  ? 1238  'X-RAY DIFFRACTION' ? 
r_gen_planes_refined         0.007  0.020  ? 11639 'X-RAY DIFFRACTION' ? 
r_gen_planes_other           0.002  0.020  ? 2535  'X-RAY DIFFRACTION' ? 
r_nbd_refined                ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbd_other                  ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbtor_refined              ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbtor_other                ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_xyhbond_nbd_refined        ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_xyhbond_nbd_other          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_metal_ion_refined          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_metal_ion_other            ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_vdw_refined       ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_vdw_other         ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_hbond_refined     ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_hbond_other       ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_metal_ion_refined ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_metal_ion_other   ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_mcbond_it                  2.538  5.744  ? 6488  'X-RAY DIFFRACTION' ? 
r_mcbond_other               2.572  5.764  ? 6317  'X-RAY DIFFRACTION' ? 
r_mcangle_it                 4.750  8.108  ? 6012  'X-RAY DIFFRACTION' ? 
r_mcangle_other              4.749  8.113  ? 6007  'X-RAY DIFFRACTION' ? 
r_scbond_it                  2.894  6.443  ? 6962  'X-RAY DIFFRACTION' ? 
r_scbond_other               2.894  6.443  ? 6962  'X-RAY DIFFRACTION' ? 
r_scangle_it                 ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_scangle_other              5.128  9.114  ? 7393  'X-RAY DIFFRACTION' ? 
r_long_range_B_refined       8.154  40.307 ? 8727  'X-RAY DIFFRACTION' ? 
r_long_range_B_other         7.950  39.899 ? 8604  'X-RAY DIFFRACTION' ? 
r_rigid_bond_restr           ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_sphericity_free            ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_sphericity_bonded          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.d_res_high                       1.600 
_refine_ls_shell.d_res_low                        1.641 
_refine_ls_shell.number_reflns_R_work             5917 
_refine_ls_shell.R_factor_R_work                  0.459 
_refine_ls_shell.percent_reflns_obs               90.07 
_refine_ls_shell.R_factor_R_free                  0.459 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.number_reflns_R_free             299 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.number_reflns_obs                ? 
# 
_struct.entry_id                  7I2B 
_struct.title                     
;Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 -- Crystal structure of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 in complex with Z68404778 (DNV2_NS5A-x0249)
;
_struct.pdbx_model_details        ? 
_struct.pdbx_CASP_flag            ? 
_struct.pdbx_model_type_details   ? 
# 
_struct_keywords.entry_id        7I2B 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
_struct_keywords.text            
;Diamond Light Source, I04-1, READDI, Dengue Virus, crystallographic fragment screening, PanDDA, XChemExplorer, cluster4x, VIRAL PROTEIN
;
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 2 ? 
D N N 3 ? 
E N N 4 ? 
F N N 4 ? 
G N N 4 ? 
H N N 5 ? 
I N N 6 ? 
J N N 6 ? 
K N N 5 ? 
L N N 7 ? 
M N N 8 ? 
N N N 9 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    Q91H74_9FLAV 
_struct_ref.pdbx_db_accession          Q91H74 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;GIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAMTD
TTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAREA
VEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENSLS
GVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRPTP
RGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGDDC
VVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQGAG
WSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPWME
DKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_struct_ref.pdbx_align_begin           2757 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              7I2B 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 3 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 637 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q91H74 
_struct_ref_seq.db_align_beg                  2757 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  3391 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       266 
_struct_ref_seq.pdbx_auth_seq_align_end       900 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 7I2B GLY A 1 ? UNP Q91H74 ? ? 'expression tag' 264 1 
1 7I2B PRO A 2 ? UNP Q91H74 ? ? 'expression tag' 265 2 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L,M,N 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASN A 10  ? GLU A 24  ? ASN A 273 GLU A 287 1 ? 15 
HELX_P HELX_P2  AA2 ASN A 59  ? LEU A 65  ? ASN A 322 LEU A 328 1 ? 7  
HELX_P HELX_P3  AA3 THR A 66  ? ILE A 71  ? THR A 329 ILE A 334 5 ? 6  
HELX_P HELX_P4  AA4 ILE A 72  ? GLN A 77  ? ILE A 335 GLN A 340 1 ? 6  
HELX_P HELX_P5  AA5 MET A 78  ? MET A 80  ? MET A 341 MET A 343 5 ? 3  
HELX_P HELX_P6  AA6 LYS A 104 ? LYS A 124 ? LYS A 367 LYS A 387 1 ? 21 
HELX_P HELX_P7  AA7 THR A 132 ? ARG A 141 ? THR A 395 ARG A 404 1 ? 10 
HELX_P HELX_P8  AA8 SER A 158 ? VAL A 163 ? SER A 421 VAL A 426 1 ? 6  
HELX_P HELX_P9  AA9 ASP A 165 ? GLU A 181 ? ASP A 428 GLU A 444 1 ? 17 
HELX_P HELX_P10 AB1 TRP A 215 ? GLY A 227 ? TRP A 478 GLY A 490 1 ? 13 
HELX_P HELX_P11 AB2 GLY A 227 ? ASP A 232 ? GLY A 490 ASP A 495 1 ? 6  
HELX_P HELX_P12 AB3 SER A 236 ? LEU A 241 ? SER A 499 LEU A 504 1 ? 6  
HELX_P HELX_P13 AB4 GLY A 248 ? LYS A 261 ? GLY A 511 LYS A 524 1 ? 14 
HELX_P HELX_P14 AB5 GLY A 274 ? ILE A 279 ? GLY A 537 ILE A 542 5 ? 6  
HELX_P HELX_P15 AB6 THR A 280 ? MET A 289 ? THR A 543 MET A 552 1 ? 10 
HELX_P HELX_P16 AB7 VAL A 290 ? MET A 294 ? VAL A 553 MET A 557 5 ? 5  
HELX_P HELX_P17 AB8 GLU A 295 ? TYR A 310 ? GLU A 558 TYR A 573 1 ? 16 
HELX_P HELX_P18 AB9 GLY A 339 ? GLU A 363 ? GLY A 602 GLU A 626 1 ? 25 
HELX_P HELX_P19 AC1 THR A 373 ? SER A 393 ? THR A 636 SER A 656 1 ? 21 
HELX_P HELX_P20 AC2 ASP A 408 ? ALA A 414 ? ASP A 671 ALA A 677 5 ? 7  
HELX_P HELX_P21 AC3 LEU A 415 ? MET A 421 ? LEU A 678 MET A 684 1 ? 7  
HELX_P HELX_P22 AC4 ASP A 439 ? VAL A 443 ? ASP A 702 VAL A 706 5 ? 5  
HELX_P HELX_P23 AC5 ASN A 467 ? ARG A 476 ? ASN A 730 ARG A 739 1 ? 10 
HELX_P HELX_P24 AC6 SER A 484 ? TYR A 503 ? SER A 747 TYR A 766 1 ? 20 
HELX_P HELX_P25 AC7 ARG A 506 ? VAL A 520 ? ARG A 769 VAL A 783 1 ? 15 
HELX_P HELX_P26 AC8 ASP A 545 ? ILE A 555 ? ASP A 808 ILE A 818 1 ? 11 
HELX_P HELX_P27 AC9 SER A 569 ? ILE A 573 ? SER A 832 ILE A 836 5 ? 5  
HELX_P HELX_P28 AD1 GLY A 577 ? CYS A 584 ? GLY A 840 CYS A 847 1 ? 8  
HELX_P HELX_P29 AD2 LEU A 590 ? ASN A 599 ? LEU A 853 ASN A 862 1 ? 10 
HELX_P HELX_P30 AD3 ASN A 599 ? GLY A 612 ? ASN A 862 GLY A 875 1 ? 14 
HELX_P HELX_P31 AD4 TYR A 619 ? ARG A 627 ? TYR A 882 ARG A 890 5 ? 9  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1 metalc ? ? A GLU 175 OE1 ? ? ? 1_555 C ZN . ZN ? ? A GLU 438 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.092 ? ? 
metalc2 metalc ? ? A HIS 179 NE2 ? ? ? 1_555 C ZN . ZN ? ? A HIS 442 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.015 ? ? 
metalc3 metalc ? ? A CYS 184 SG  ? ? ? 1_555 C ZN . ZN ? ? A CYS 447 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.206 ? ? 
metalc4 metalc ? ? A CYS 187 SG  ? ? ? 1_555 C ZN . ZN ? ? A CYS 450 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.175 ? ? 
metalc5 metalc ? ? A HIS 449 NE2 ? ? ? 1_555 B ZN . ZN ? ? A HIS 712 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.089 ? ? 
metalc6 metalc ? ? A HIS 451 NE2 ? ? ? 1_555 B ZN . ZN ? ? A HIS 714 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.019 ? ? 
metalc7 metalc ? ? A CYS 465 SG  ? ? ? 1_555 B ZN . ZN ? ? A CYS 728 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.320 ? ? 
metalc8 metalc ? ? A CYS 584 SG  ? ? ? 1_555 B ZN . ZN ? ? A CYS 847 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.326 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  OE1 ? A GLU 175 ? A GLU 438 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 NE2 ? A HIS 179 ? A HIS 442 ? 1_555 104.2 ? 
2  OE1 ? A GLU 175 ? A GLU 438 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 184 ? A CYS 447 ? 1_555 118.8 ? 
3  NE2 ? A HIS 179 ? A HIS 442 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 184 ? A CYS 447 ? 1_555 118.7 ? 
4  OE1 ? A GLU 175 ? A GLU 438 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 84.6  ? 
5  NE2 ? A HIS 179 ? A HIS 442 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 115.0 ? 
6  SG  ? A CYS 184 ? A CYS 447 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 110.9 ? 
7  NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 NE2 ? A HIS 451 ? A HIS 714 ? 1_555 103.7 ? 
8  NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 465 ? A CYS 728 ? 1_555 105.0 ? 
9  NE2 ? A HIS 451 ? A HIS 714 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 465 ? A CYS 728 ? 1_555 109.0 ? 
10 NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 104.7 ? 
11 NE2 ? A HIS 451 ? A HIS 714 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 113.7 ? 
12 SG  ? A CYS 465 ? A CYS 728 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 119.1 ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 2 ? 
AA3 ? 2 ? 
AA4 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? parallel      
AA1 4 5 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ALA A 41  ? TYR A 42  ? ALA A 304 TYR A 305 
AA1 2 VAL A 326 ? ARG A 332 ? VAL A 589 ARG A 595 
AA1 3 LYS A 313 ? ARG A 319 ? LYS A 576 ARG A 582 
AA1 4 TYR A 189 ? MET A 191 ? TYR A 452 MET A 454 
AA1 5 TRP A 212 ? TYR A 213 ? TRP A 475 TYR A 476 
AA2 1 MET A 57  ? VAL A 58  ? MET A 320 VAL A 321 
AA2 2 ILE A 477 ? SER A 478 ? ILE A 740 SER A 741 
AA3 1 MET A 395 ? SER A 398 ? MET A 658 SER A 661 
AA3 2 ASP A 401 ? VAL A 404 ? ASP A 664 VAL A 667 
AA4 1 HIS A 449 ? ILE A 454 ? HIS A 712 ILE A 717 
AA4 2 VAL A 460 ? CYS A 465 ? VAL A 723 CYS A 728 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ALA A 41  ? N ALA A 304 O SER A 331 ? O SER A 594 
AA1 2 3 O ILE A 330 ? O ILE A 593 N VAL A 315 ? N VAL A 578 
AA1 3 4 O VAL A 314 ? O VAL A 577 N TYR A 189 ? N TYR A 452 
AA1 4 5 N ASN A 190 ? N ASN A 453 O TYR A 213 ? O TYR A 476 
AA2 1 2 N MET A 57  ? N MET A 320 O SER A 478 ? O SER A 741 
AA3 1 2 N SER A 398 ? N SER A 661 O ASP A 401 ? O ASP A 664 
AA4 1 2 N LEU A 453 ? N LEU A 716 O LEU A 461 ? O LEU A 724 
# 
_pdbx_entry_details.entry_id                   7I2B 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 OD1 A ASP 664 ? ? O4 A PO4 1008 ? ? 1.89 
2 1 OG  A SER 505 ? ? O  A LEU 655  ? ? 2.19 
# 
_pdbx_validate_symm_contact.id                1 
_pdbx_validate_symm_contact.PDB_model_num     1 
_pdbx_validate_symm_contact.auth_atom_id_1    O 
_pdbx_validate_symm_contact.auth_asym_id_1    A 
_pdbx_validate_symm_contact.auth_comp_id_1    HOH 
_pdbx_validate_symm_contact.auth_seq_id_1     1139 
_pdbx_validate_symm_contact.PDB_ins_code_1    ? 
_pdbx_validate_symm_contact.label_alt_id_1    ? 
_pdbx_validate_symm_contact.site_symmetry_1   1_555 
_pdbx_validate_symm_contact.auth_atom_id_2    O 
_pdbx_validate_symm_contact.auth_asym_id_2    A 
_pdbx_validate_symm_contact.auth_comp_id_2    HOH 
_pdbx_validate_symm_contact.auth_seq_id_2     1139 
_pdbx_validate_symm_contact.PDB_ins_code_2    ? 
_pdbx_validate_symm_contact.label_alt_id_2    ? 
_pdbx_validate_symm_contact.site_symmetry_2   2_445 
_pdbx_validate_symm_contact.dist              1.67 
# 
_pdbx_validate_rmsd_angle.id                         1 
_pdbx_validate_rmsd_angle.PDB_model_num              1 
_pdbx_validate_rmsd_angle.auth_atom_id_1             NE 
_pdbx_validate_rmsd_angle.auth_asym_id_1             A 
_pdbx_validate_rmsd_angle.auth_comp_id_1             ARG 
_pdbx_validate_rmsd_angle.auth_seq_id_1              739 
_pdbx_validate_rmsd_angle.PDB_ins_code_1             ? 
_pdbx_validate_rmsd_angle.label_alt_id_1             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_2             CZ 
_pdbx_validate_rmsd_angle.auth_asym_id_2             A 
_pdbx_validate_rmsd_angle.auth_comp_id_2             ARG 
_pdbx_validate_rmsd_angle.auth_seq_id_2              739 
_pdbx_validate_rmsd_angle.PDB_ins_code_2             ? 
_pdbx_validate_rmsd_angle.label_alt_id_2             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_3             NH1 
_pdbx_validate_rmsd_angle.auth_asym_id_3             A 
_pdbx_validate_rmsd_angle.auth_comp_id_3             ARG 
_pdbx_validate_rmsd_angle.auth_seq_id_3              739 
_pdbx_validate_rmsd_angle.PDB_ins_code_3             ? 
_pdbx_validate_rmsd_angle.label_alt_id_3             ? 
_pdbx_validate_rmsd_angle.angle_value                123.76 
_pdbx_validate_rmsd_angle.angle_target_value         120.30 
_pdbx_validate_rmsd_angle.angle_deviation            3.46 
_pdbx_validate_rmsd_angle.angle_standard_deviation   0.50 
_pdbx_validate_rmsd_angle.linker_flag                N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 HIS A 288 ? ? -145.85 23.31   
2  1 SER A 291 ? ? -155.07 10.52   
3  1 TYR A 309 ? ? -172.33 143.24  
4  1 GLU A 357 ? ? 86.08   -5.91   
5  1 ASN A 406 ? ? 59.29   101.90  
6  1 ALA A 408 ? ? -69.17  71.65   
7  1 LYS A 420 ? ? -73.57  -96.26  
8  1 LEU A 504 ? ? 71.17   -40.15  
9  1 GLN A 598 ? ? 79.09   160.25  
10 1 SER A 601 ? ? -69.15  -173.96 
11 1 SER A 791 ? ? -161.69 117.99  
12 1 ASN A 876 ? ? -68.15  97.70   
# 
_pdbx_validate_main_chain_plane.id                       1 
_pdbx_validate_main_chain_plane.PDB_model_num            1 
_pdbx_validate_main_chain_plane.auth_comp_id             SER 
_pdbx_validate_main_chain_plane.auth_asym_id             A 
_pdbx_validate_main_chain_plane.auth_seq_id              741 
_pdbx_validate_main_chain_plane.PDB_ins_code             ? 
_pdbx_validate_main_chain_plane.label_alt_id             B 
_pdbx_validate_main_chain_plane.improper_torsion_angle   10.05 
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A HOH 1226 ? N HOH . 
2 1 A HOH 1227 ? N HOH . 
3 1 A HOH 1414 ? N HOH . 
4 1 A HOH 1461 ? N HOH . 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 1491 ? 5.96 . 
2 1 O ? A HOH 1492 ? 6.39 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY 264 ? A GLY 1   
2  1 Y 1 A PRO 265 ? A PRO 2   
3  1 Y 1 A GLY 266 ? A GLY 3   
4  1 Y 1 A ILE 267 ? A ILE 4   
5  1 Y 1 A GLU 268 ? A GLU 5   
6  1 Y 1 A SER 269 ? A SER 6   
7  1 Y 1 A GLU 270 ? A GLU 7   
8  1 Y 1 A THR 271 ? A THR 8   
9  1 Y 1 A PRO 272 ? A PRO 9   
10 1 Y 1 A LYS 312 ? A LYS 49  
11 1 Y 1 A GLN 313 ? A GLN 50  
12 1 Y 1 A THR 314 ? A THR 51  
13 1 Y 1 A GLY 315 ? A GLY 52  
14 1 Y 1 A SER 316 ? A SER 53  
15 1 Y 1 A ASP 345 ? A ASP 82  
16 1 Y 1 A THR 346 ? A THR 83  
17 1 Y 1 A THR 347 ? A THR 84  
18 1 Y 1 A PRO 348 ? A PRO 85  
19 1 Y 1 A PHE 349 ? A PHE 86  
20 1 Y 1 A GLY 350 ? A GLY 87  
21 1 Y 1 A GLN 351 ? A GLN 88  
22 1 Y 1 A GLN 352 ? A GLN 89  
23 1 Y 1 A ARG 353 ? A ARG 90  
24 1 Y 1 A VAL 354 ? A VAL 91  
25 1 Y 1 A PHE 355 ? A PHE 92  
26 1 Y 1 A PHE 413 ? A PHE 150 
27 1 Y 1 A THR 414 ? A THR 151 
28 1 Y 1 A ASP 415 ? A ASP 152 
29 1 Y 1 A GLU 416 ? A GLU 153 
30 1 Y 1 A ASN 417 ? A ASN 154 
31 1 Y 1 A GLY 456 ? A GLY 193 
32 1 Y 1 A LYS 457 ? A LYS 194 
33 1 Y 1 A ARG 458 ? A ARG 195 
34 1 Y 1 A GLU 459 ? A GLU 196 
35 1 Y 1 A LYS 460 ? A LYS 197 
36 1 Y 1 A LYS 461 ? A LYS 198 
37 1 Y 1 A LEU 462 ? A LEU 199 
38 1 Y 1 A GLY 463 ? A GLY 200 
39 1 Y 1 A GLU 464 ? A GLU 201 
40 1 Y 1 A PHE 465 ? A PHE 202 
41 1 Y 1 A GLY 466 ? A GLY 203 
42 1 Y 1 A LYS 467 ? A LYS 204 
43 1 Y 1 A ALA 468 ? A ALA 205 
44 1 Y 1 A LYS 469 ? A LYS 206 
45 1 Y 1 A GLY 470 ? A GLY 207 
46 1 Y 1 A SER 471 ? A SER 208 
47 1 Y 1 A ARG 472 ? A ARG 209 
48 1 Y 1 A PRO 585 ? A PRO 322 
49 1 Y 1 A ARG 586 ? A ARG 323 
50 1 Y 1 A GLY 587 ? A GLY 324 
51 1 Y 1 A THR 794 ? A THR 531 
52 1 Y 1 A TRP 795 ? A TRP 532 
53 1 Y 1 A SER 796 ? A SER 533 
54 1 Y 1 A ILE 797 ? A ILE 534 
55 1 Y 1 A HIS 798 ? A HIS 535 
56 1 Y 1 A GLU 892 ? A GLU 629 
57 1 Y 1 A GLU 893 ? A GLU 630 
58 1 Y 1 A GLU 894 ? A GLU 631 
59 1 Y 1 A GLU 895 ? A GLU 632 
60 1 Y 1 A ALA 896 ? A ALA 633 
61 1 Y 1 A GLY 897 ? A GLY 634 
62 1 Y 1 A VAL 898 ? A VAL 635 
63 1 Y 1 A LEU 899 ? A LEU 636 
64 1 Y 1 A TRP 900 ? A TRP 637 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
B1A N1   N  N N 74  
B1A C4   C  Y N 75  
B1A C5   C  Y N 76  
B1A C6   C  Y N 77  
B1A C7   C  Y N 78  
B1A C8   C  Y N 79  
B1A C10  C  Y N 80  
B1A C13  C  Y N 81  
B1A C1   C  N N 82  
B1A C2   C  N N 83  
B1A O1   O  N N 84  
B1A C3   C  Y N 85  
B1A N2   N  N N 86  
B1A C9   C  Y N 87  
B1A C11  C  Y N 88  
B1A C12  C  Y N 89  
B1A C14  C  Y N 90  
B1A H1   H  N N 91  
B1A H2   H  N N 92  
B1A H3   H  N N 93  
B1A H4   H  N N 94  
B1A H5   H  N N 95  
B1A H6   H  N N 96  
B1A H7   H  N N 97  
B1A H8   H  N N 98  
B1A H9   H  N N 99  
B1A H10  H  N N 100 
B1A H11  H  N N 101 
B1A H12  H  N N 102 
B1A H13  H  N N 103 
B1A H14  H  N N 104 
CL  CL   CL N N 105 
CYS N    N  N N 106 
CYS CA   C  N R 107 
CYS C    C  N N 108 
CYS O    O  N N 109 
CYS CB   C  N N 110 
CYS SG   S  N N 111 
CYS OXT  O  N N 112 
CYS H    H  N N 113 
CYS H2   H  N N 114 
CYS HA   H  N N 115 
CYS HB2  H  N N 116 
CYS HB3  H  N N 117 
CYS HG   H  N N 118 
CYS HXT  H  N N 119 
DMS S    S  N N 120 
DMS O    O  N N 121 
DMS C1   C  N N 122 
DMS C2   C  N N 123 
DMS H11  H  N N 124 
DMS H12  H  N N 125 
DMS H13  H  N N 126 
DMS H21  H  N N 127 
DMS H22  H  N N 128 
DMS H23  H  N N 129 
GLN N    N  N N 130 
GLN CA   C  N S 131 
GLN C    C  N N 132 
GLN O    O  N N 133 
GLN CB   C  N N 134 
GLN CG   C  N N 135 
GLN CD   C  N N 136 
GLN OE1  O  N N 137 
GLN NE2  N  N N 138 
GLN OXT  O  N N 139 
GLN H    H  N N 140 
GLN H2   H  N N 141 
GLN HA   H  N N 142 
GLN HB2  H  N N 143 
GLN HB3  H  N N 144 
GLN HG2  H  N N 145 
GLN HG3  H  N N 146 
GLN HE21 H  N N 147 
GLN HE22 H  N N 148 
GLN HXT  H  N N 149 
GLU N    N  N N 150 
GLU CA   C  N S 151 
GLU C    C  N N 152 
GLU O    O  N N 153 
GLU CB   C  N N 154 
GLU CG   C  N N 155 
GLU CD   C  N N 156 
GLU OE1  O  N N 157 
GLU OE2  O  N N 158 
GLU OXT  O  N N 159 
GLU H    H  N N 160 
GLU H2   H  N N 161 
GLU HA   H  N N 162 
GLU HB2  H  N N 163 
GLU HB3  H  N N 164 
GLU HG2  H  N N 165 
GLU HG3  H  N N 166 
GLU HE2  H  N N 167 
GLU HXT  H  N N 168 
GLY N    N  N N 169 
GLY CA   C  N N 170 
GLY C    C  N N 171 
GLY O    O  N N 172 
GLY OXT  O  N N 173 
GLY H    H  N N 174 
GLY H2   H  N N 175 
GLY HA2  H  N N 176 
GLY HA3  H  N N 177 
GLY HXT  H  N N 178 
HIS N    N  N N 179 
HIS CA   C  N S 180 
HIS C    C  N N 181 
HIS O    O  N N 182 
HIS CB   C  N N 183 
HIS CG   C  Y N 184 
HIS ND1  N  Y N 185 
HIS CD2  C  Y N 186 
HIS CE1  C  Y N 187 
HIS NE2  N  Y N 188 
HIS OXT  O  N N 189 
HIS H    H  N N 190 
HIS H2   H  N N 191 
HIS HA   H  N N 192 
HIS HB2  H  N N 193 
HIS HB3  H  N N 194 
HIS HD1  H  N N 195 
HIS HD2  H  N N 196 
HIS HE1  H  N N 197 
HIS HE2  H  N N 198 
HIS HXT  H  N N 199 
HOH O    O  N N 200 
HOH H1   H  N N 201 
HOH H2   H  N N 202 
ILE N    N  N N 203 
ILE CA   C  N S 204 
ILE C    C  N N 205 
ILE O    O  N N 206 
ILE CB   C  N S 207 
ILE CG1  C  N N 208 
ILE CG2  C  N N 209 
ILE CD1  C  N N 210 
ILE OXT  O  N N 211 
ILE H    H  N N 212 
ILE H2   H  N N 213 
ILE HA   H  N N 214 
ILE HB   H  N N 215 
ILE HG12 H  N N 216 
ILE HG13 H  N N 217 
ILE HG21 H  N N 218 
ILE HG22 H  N N 219 
ILE HG23 H  N N 220 
ILE HD11 H  N N 221 
ILE HD12 H  N N 222 
ILE HD13 H  N N 223 
ILE HXT  H  N N 224 
LEU N    N  N N 225 
LEU CA   C  N S 226 
LEU C    C  N N 227 
LEU O    O  N N 228 
LEU CB   C  N N 229 
LEU CG   C  N N 230 
LEU CD1  C  N N 231 
LEU CD2  C  N N 232 
LEU OXT  O  N N 233 
LEU H    H  N N 234 
LEU H2   H  N N 235 
LEU HA   H  N N 236 
LEU HB2  H  N N 237 
LEU HB3  H  N N 238 
LEU HG   H  N N 239 
LEU HD11 H  N N 240 
LEU HD12 H  N N 241 
LEU HD13 H  N N 242 
LEU HD21 H  N N 243 
LEU HD22 H  N N 244 
LEU HD23 H  N N 245 
LEU HXT  H  N N 246 
LYS N    N  N N 247 
LYS CA   C  N S 248 
LYS C    C  N N 249 
LYS O    O  N N 250 
LYS CB   C  N N 251 
LYS CG   C  N N 252 
LYS CD   C  N N 253 
LYS CE   C  N N 254 
LYS NZ   N  N N 255 
LYS OXT  O  N N 256 
LYS H    H  N N 257 
LYS H2   H  N N 258 
LYS HA   H  N N 259 
LYS HB2  H  N N 260 
LYS HB3  H  N N 261 
LYS HG2  H  N N 262 
LYS HG3  H  N N 263 
LYS HD2  H  N N 264 
LYS HD3  H  N N 265 
LYS HE2  H  N N 266 
LYS HE3  H  N N 267 
LYS HZ1  H  N N 268 
LYS HZ2  H  N N 269 
LYS HZ3  H  N N 270 
LYS HXT  H  N N 271 
MES O1   O  N N 272 
MES C2   C  N N 273 
MES C3   C  N N 274 
MES N4   N  N N 275 
MES C5   C  N N 276 
MES C6   C  N N 277 
MES C7   C  N N 278 
MES C8   C  N N 279 
MES S    S  N N 280 
MES O1S  O  N N 281 
MES O2S  O  N N 282 
MES O3S  O  N N 283 
MES H21  H  N N 284 
MES H22  H  N N 285 
MES H31  H  N N 286 
MES H32  H  N N 287 
MES HN4  H  N N 288 
MES H51  H  N N 289 
MES H52  H  N N 290 
MES H61  H  N N 291 
MES H62  H  N N 292 
MES H71  H  N N 293 
MES H72  H  N N 294 
MES H81  H  N N 295 
MES H82  H  N N 296 
MET N    N  N N 297 
MET CA   C  N S 298 
MET C    C  N N 299 
MET O    O  N N 300 
MET CB   C  N N 301 
MET CG   C  N N 302 
MET SD   S  N N 303 
MET CE   C  N N 304 
MET OXT  O  N N 305 
MET H    H  N N 306 
MET H2   H  N N 307 
MET HA   H  N N 308 
MET HB2  H  N N 309 
MET HB3  H  N N 310 
MET HG2  H  N N 311 
MET HG3  H  N N 312 
MET HE1  H  N N 313 
MET HE2  H  N N 314 
MET HE3  H  N N 315 
MET HXT  H  N N 316 
PEG C1   C  N N 317 
PEG O1   O  N N 318 
PEG C2   C  N N 319 
PEG O2   O  N N 320 
PEG C3   C  N N 321 
PEG C4   C  N N 322 
PEG O4   O  N N 323 
PEG H11  H  N N 324 
PEG H12  H  N N 325 
PEG HO1  H  N N 326 
PEG H21  H  N N 327 
PEG H22  H  N N 328 
PEG H31  H  N N 329 
PEG H32  H  N N 330 
PEG H41  H  N N 331 
PEG H42  H  N N 332 
PEG HO4  H  N N 333 
PHE N    N  N N 334 
PHE CA   C  N S 335 
PHE C    C  N N 336 
PHE O    O  N N 337 
PHE CB   C  N N 338 
PHE CG   C  Y N 339 
PHE CD1  C  Y N 340 
PHE CD2  C  Y N 341 
PHE CE1  C  Y N 342 
PHE CE2  C  Y N 343 
PHE CZ   C  Y N 344 
PHE OXT  O  N N 345 
PHE H    H  N N 346 
PHE H2   H  N N 347 
PHE HA   H  N N 348 
PHE HB2  H  N N 349 
PHE HB3  H  N N 350 
PHE HD1  H  N N 351 
PHE HD2  H  N N 352 
PHE HE1  H  N N 353 
PHE HE2  H  N N 354 
PHE HZ   H  N N 355 
PHE HXT  H  N N 356 
PO4 P    P  N N 357 
PO4 O1   O  N N 358 
PO4 O2   O  N N 359 
PO4 O3   O  N N 360 
PO4 O4   O  N N 361 
PRO N    N  N N 362 
PRO CA   C  N S 363 
PRO C    C  N N 364 
PRO O    O  N N 365 
PRO CB   C  N N 366 
PRO CG   C  N N 367 
PRO CD   C  N N 368 
PRO OXT  O  N N 369 
PRO H    H  N N 370 
PRO HA   H  N N 371 
PRO HB2  H  N N 372 
PRO HB3  H  N N 373 
PRO HG2  H  N N 374 
PRO HG3  H  N N 375 
PRO HD2  H  N N 376 
PRO HD3  H  N N 377 
PRO HXT  H  N N 378 
SER N    N  N N 379 
SER CA   C  N S 380 
SER C    C  N N 381 
SER O    O  N N 382 
SER CB   C  N N 383 
SER OG   O  N N 384 
SER OXT  O  N N 385 
SER H    H  N N 386 
SER H2   H  N N 387 
SER HA   H  N N 388 
SER HB2  H  N N 389 
SER HB3  H  N N 390 
SER HG   H  N N 391 
SER HXT  H  N N 392 
THR N    N  N N 393 
THR CA   C  N S 394 
THR C    C  N N 395 
THR O    O  N N 396 
THR CB   C  N R 397 
THR OG1  O  N N 398 
THR CG2  C  N N 399 
THR OXT  O  N N 400 
THR H    H  N N 401 
THR H2   H  N N 402 
THR HA   H  N N 403 
THR HB   H  N N 404 
THR HG1  H  N N 405 
THR HG21 H  N N 406 
THR HG22 H  N N 407 
THR HG23 H  N N 408 
THR HXT  H  N N 409 
TRP N    N  N N 410 
TRP CA   C  N S 411 
TRP C    C  N N 412 
TRP O    O  N N 413 
TRP CB   C  N N 414 
TRP CG   C  Y N 415 
TRP CD1  C  Y N 416 
TRP CD2  C  Y N 417 
TRP NE1  N  Y N 418 
TRP CE2  C  Y N 419 
TRP CE3  C  Y N 420 
TRP CZ2  C  Y N 421 
TRP CZ3  C  Y N 422 
TRP CH2  C  Y N 423 
TRP OXT  O  N N 424 
TRP H    H  N N 425 
TRP H2   H  N N 426 
TRP HA   H  N N 427 
TRP HB2  H  N N 428 
TRP HB3  H  N N 429 
TRP HD1  H  N N 430 
TRP HE1  H  N N 431 
TRP HE3  H  N N 432 
TRP HZ2  H  N N 433 
TRP HZ3  H  N N 434 
TRP HH2  H  N N 435 
TRP HXT  H  N N 436 
TYR N    N  N N 437 
TYR CA   C  N S 438 
TYR C    C  N N 439 
TYR O    O  N N 440 
TYR CB   C  N N 441 
TYR CG   C  Y N 442 
TYR CD1  C  Y N 443 
TYR CD2  C  Y N 444 
TYR CE1  C  Y N 445 
TYR CE2  C  Y N 446 
TYR CZ   C  Y N 447 
TYR OH   O  N N 448 
TYR OXT  O  N N 449 
TYR H    H  N N 450 
TYR H2   H  N N 451 
TYR HA   H  N N 452 
TYR HB2  H  N N 453 
TYR HB3  H  N N 454 
TYR HD1  H  N N 455 
TYR HD2  H  N N 456 
TYR HE1  H  N N 457 
TYR HE2  H  N N 458 
TYR HH   H  N N 459 
TYR HXT  H  N N 460 
VAL N    N  N N 461 
VAL CA   C  N S 462 
VAL C    C  N N 463 
VAL O    O  N N 464 
VAL CB   C  N N 465 
VAL CG1  C  N N 466 
VAL CG2  C  N N 467 
VAL OXT  O  N N 468 
VAL H    H  N N 469 
VAL H2   H  N N 470 
VAL HA   H  N N 471 
VAL HB   H  N N 472 
VAL HG11 H  N N 473 
VAL HG12 H  N N 474 
VAL HG13 H  N N 475 
VAL HG21 H  N N 476 
VAL HG22 H  N N 477 
VAL HG23 H  N N 478 
VAL HXT  H  N N 479 
ZN  ZN   ZN N N 480 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
B1A C11 C12  doub Y N 70  
B1A C11 C10  sing Y N 71  
B1A C12 C13  sing Y N 72  
B1A C10 C9   doub Y N 73  
B1A C13 C14  doub Y N 74  
B1A C9  C14  sing Y N 75  
B1A C9  N2   sing N N 76  
B1A C7  C8   doub Y N 77  
B1A C7  C6   sing Y N 78  
B1A C8  C3   sing Y N 79  
B1A N2  C6   sing N N 80  
B1A C6  C5   doub Y N 81  
B1A C3  N1   sing N N 82  
B1A C3  C4   doub Y N 83  
B1A C1  C2   sing N N 84  
B1A N1  C2   sing N N 85  
B1A C5  C4   sing Y N 86  
B1A C2  O1   doub N N 87  
B1A N1  H1   sing N N 88  
B1A C4  H2   sing N N 89  
B1A C5  H3   sing N N 90  
B1A C7  H4   sing N N 91  
B1A C8  H5   sing N N 92  
B1A C10 H6   sing N N 93  
B1A C13 H7   sing N N 94  
B1A C1  H8   sing N N 95  
B1A C1  H9   sing N N 96  
B1A C1  H10  sing N N 97  
B1A N2  H11  sing N N 98  
B1A C11 H12  sing N N 99  
B1A C12 H13  sing N N 100 
B1A C14 H14  sing N N 101 
CYS N   CA   sing N N 102 
CYS N   H    sing N N 103 
CYS N   H2   sing N N 104 
CYS CA  C    sing N N 105 
CYS CA  CB   sing N N 106 
CYS CA  HA   sing N N 107 
CYS C   O    doub N N 108 
CYS C   OXT  sing N N 109 
CYS CB  SG   sing N N 110 
CYS CB  HB2  sing N N 111 
CYS CB  HB3  sing N N 112 
CYS SG  HG   sing N N 113 
CYS OXT HXT  sing N N 114 
DMS S   O    doub N N 115 
DMS S   C1   sing N N 116 
DMS S   C2   sing N N 117 
DMS C1  H11  sing N N 118 
DMS C1  H12  sing N N 119 
DMS C1  H13  sing N N 120 
DMS C2  H21  sing N N 121 
DMS C2  H22  sing N N 122 
DMS C2  H23  sing N N 123 
GLN N   CA   sing N N 124 
GLN N   H    sing N N 125 
GLN N   H2   sing N N 126 
GLN CA  C    sing N N 127 
GLN CA  CB   sing N N 128 
GLN CA  HA   sing N N 129 
GLN C   O    doub N N 130 
GLN C   OXT  sing N N 131 
GLN CB  CG   sing N N 132 
GLN CB  HB2  sing N N 133 
GLN CB  HB3  sing N N 134 
GLN CG  CD   sing N N 135 
GLN CG  HG2  sing N N 136 
GLN CG  HG3  sing N N 137 
GLN CD  OE1  doub N N 138 
GLN CD  NE2  sing N N 139 
GLN NE2 HE21 sing N N 140 
GLN NE2 HE22 sing N N 141 
GLN OXT HXT  sing N N 142 
GLU N   CA   sing N N 143 
GLU N   H    sing N N 144 
GLU N   H2   sing N N 145 
GLU CA  C    sing N N 146 
GLU CA  CB   sing N N 147 
GLU CA  HA   sing N N 148 
GLU C   O    doub N N 149 
GLU C   OXT  sing N N 150 
GLU CB  CG   sing N N 151 
GLU CB  HB2  sing N N 152 
GLU CB  HB3  sing N N 153 
GLU CG  CD   sing N N 154 
GLU CG  HG2  sing N N 155 
GLU CG  HG3  sing N N 156 
GLU CD  OE1  doub N N 157 
GLU CD  OE2  sing N N 158 
GLU OE2 HE2  sing N N 159 
GLU OXT HXT  sing N N 160 
GLY N   CA   sing N N 161 
GLY N   H    sing N N 162 
GLY N   H2   sing N N 163 
GLY CA  C    sing N N 164 
GLY CA  HA2  sing N N 165 
GLY CA  HA3  sing N N 166 
GLY C   O    doub N N 167 
GLY C   OXT  sing N N 168 
GLY OXT HXT  sing N N 169 
HIS N   CA   sing N N 170 
HIS N   H    sing N N 171 
HIS N   H2   sing N N 172 
HIS CA  C    sing N N 173 
HIS CA  CB   sing N N 174 
HIS CA  HA   sing N N 175 
HIS C   O    doub N N 176 
HIS C   OXT  sing N N 177 
HIS CB  CG   sing N N 178 
HIS CB  HB2  sing N N 179 
HIS CB  HB3  sing N N 180 
HIS CG  ND1  sing Y N 181 
HIS CG  CD2  doub Y N 182 
HIS ND1 CE1  doub Y N 183 
HIS ND1 HD1  sing N N 184 
HIS CD2 NE2  sing Y N 185 
HIS CD2 HD2  sing N N 186 
HIS CE1 NE2  sing Y N 187 
HIS CE1 HE1  sing N N 188 
HIS NE2 HE2  sing N N 189 
HIS OXT HXT  sing N N 190 
HOH O   H1   sing N N 191 
HOH O   H2   sing N N 192 
ILE N   CA   sing N N 193 
ILE N   H    sing N N 194 
ILE N   H2   sing N N 195 
ILE CA  C    sing N N 196 
ILE CA  CB   sing N N 197 
ILE CA  HA   sing N N 198 
ILE C   O    doub N N 199 
ILE C   OXT  sing N N 200 
ILE CB  CG1  sing N N 201 
ILE CB  CG2  sing N N 202 
ILE CB  HB   sing N N 203 
ILE CG1 CD1  sing N N 204 
ILE CG1 HG12 sing N N 205 
ILE CG1 HG13 sing N N 206 
ILE CG2 HG21 sing N N 207 
ILE CG2 HG22 sing N N 208 
ILE CG2 HG23 sing N N 209 
ILE CD1 HD11 sing N N 210 
ILE CD1 HD12 sing N N 211 
ILE CD1 HD13 sing N N 212 
ILE OXT HXT  sing N N 213 
LEU N   CA   sing N N 214 
LEU N   H    sing N N 215 
LEU N   H2   sing N N 216 
LEU CA  C    sing N N 217 
LEU CA  CB   sing N N 218 
LEU CA  HA   sing N N 219 
LEU C   O    doub N N 220 
LEU C   OXT  sing N N 221 
LEU CB  CG   sing N N 222 
LEU CB  HB2  sing N N 223 
LEU CB  HB3  sing N N 224 
LEU CG  CD1  sing N N 225 
LEU CG  CD2  sing N N 226 
LEU CG  HG   sing N N 227 
LEU CD1 HD11 sing N N 228 
LEU CD1 HD12 sing N N 229 
LEU CD1 HD13 sing N N 230 
LEU CD2 HD21 sing N N 231 
LEU CD2 HD22 sing N N 232 
LEU CD2 HD23 sing N N 233 
LEU OXT HXT  sing N N 234 
LYS N   CA   sing N N 235 
LYS N   H    sing N N 236 
LYS N   H2   sing N N 237 
LYS CA  C    sing N N 238 
LYS CA  CB   sing N N 239 
LYS CA  HA   sing N N 240 
LYS C   O    doub N N 241 
LYS C   OXT  sing N N 242 
LYS CB  CG   sing N N 243 
LYS CB  HB2  sing N N 244 
LYS CB  HB3  sing N N 245 
LYS CG  CD   sing N N 246 
LYS CG  HG2  sing N N 247 
LYS CG  HG3  sing N N 248 
LYS CD  CE   sing N N 249 
LYS CD  HD2  sing N N 250 
LYS CD  HD3  sing N N 251 
LYS CE  NZ   sing N N 252 
LYS CE  HE2  sing N N 253 
LYS CE  HE3  sing N N 254 
LYS NZ  HZ1  sing N N 255 
LYS NZ  HZ2  sing N N 256 
LYS NZ  HZ3  sing N N 257 
LYS OXT HXT  sing N N 258 
MES O1  C2   sing N N 259 
MES O1  C6   sing N N 260 
MES C2  C3   sing N N 261 
MES C2  H21  sing N N 262 
MES C2  H22  sing N N 263 
MES C3  N4   sing N N 264 
MES C3  H31  sing N N 265 
MES C3  H32  sing N N 266 
MES N4  C5   sing N N 267 
MES N4  C7   sing N N 268 
MES N4  HN4  sing N N 269 
MES C5  C6   sing N N 270 
MES C5  H51  sing N N 271 
MES C5  H52  sing N N 272 
MES C6  H61  sing N N 273 
MES C6  H62  sing N N 274 
MES C7  C8   sing N N 275 
MES C7  H71  sing N N 276 
MES C7  H72  sing N N 277 
MES C8  S    sing N N 278 
MES C8  H81  sing N N 279 
MES C8  H82  sing N N 280 
MES S   O1S  doub N N 281 
MES S   O2S  doub N N 282 
MES S   O3S  sing N N 283 
MET N   CA   sing N N 284 
MET N   H    sing N N 285 
MET N   H2   sing N N 286 
MET CA  C    sing N N 287 
MET CA  CB   sing N N 288 
MET CA  HA   sing N N 289 
MET C   O    doub N N 290 
MET C   OXT  sing N N 291 
MET CB  CG   sing N N 292 
MET CB  HB2  sing N N 293 
MET CB  HB3  sing N N 294 
MET CG  SD   sing N N 295 
MET CG  HG2  sing N N 296 
MET CG  HG3  sing N N 297 
MET SD  CE   sing N N 298 
MET CE  HE1  sing N N 299 
MET CE  HE2  sing N N 300 
MET CE  HE3  sing N N 301 
MET OXT HXT  sing N N 302 
PEG C1  O1   sing N N 303 
PEG C1  C2   sing N N 304 
PEG C1  H11  sing N N 305 
PEG C1  H12  sing N N 306 
PEG O1  HO1  sing N N 307 
PEG C2  O2   sing N N 308 
PEG C2  H21  sing N N 309 
PEG C2  H22  sing N N 310 
PEG O2  C3   sing N N 311 
PEG C3  C4   sing N N 312 
PEG C3  H31  sing N N 313 
PEG C3  H32  sing N N 314 
PEG C4  O4   sing N N 315 
PEG C4  H41  sing N N 316 
PEG C4  H42  sing N N 317 
PEG O4  HO4  sing N N 318 
PHE N   CA   sing N N 319 
PHE N   H    sing N N 320 
PHE N   H2   sing N N 321 
PHE CA  C    sing N N 322 
PHE CA  CB   sing N N 323 
PHE CA  HA   sing N N 324 
PHE C   O    doub N N 325 
PHE C   OXT  sing N N 326 
PHE CB  CG   sing N N 327 
PHE CB  HB2  sing N N 328 
PHE CB  HB3  sing N N 329 
PHE CG  CD1  doub Y N 330 
PHE CG  CD2  sing Y N 331 
PHE CD1 CE1  sing Y N 332 
PHE CD1 HD1  sing N N 333 
PHE CD2 CE2  doub Y N 334 
PHE CD2 HD2  sing N N 335 
PHE CE1 CZ   doub Y N 336 
PHE CE1 HE1  sing N N 337 
PHE CE2 CZ   sing Y N 338 
PHE CE2 HE2  sing N N 339 
PHE CZ  HZ   sing N N 340 
PHE OXT HXT  sing N N 341 
PO4 P   O1   doub N N 342 
PO4 P   O2   sing N N 343 
PO4 P   O3   sing N N 344 
PO4 P   O4   sing N N 345 
PRO N   CA   sing N N 346 
PRO N   CD   sing N N 347 
PRO N   H    sing N N 348 
PRO CA  C    sing N N 349 
PRO CA  CB   sing N N 350 
PRO CA  HA   sing N N 351 
PRO C   O    doub N N 352 
PRO C   OXT  sing N N 353 
PRO CB  CG   sing N N 354 
PRO CB  HB2  sing N N 355 
PRO CB  HB3  sing N N 356 
PRO CG  CD   sing N N 357 
PRO CG  HG2  sing N N 358 
PRO CG  HG3  sing N N 359 
PRO CD  HD2  sing N N 360 
PRO CD  HD3  sing N N 361 
PRO OXT HXT  sing N N 362 
SER N   CA   sing N N 363 
SER N   H    sing N N 364 
SER N   H2   sing N N 365 
SER CA  C    sing N N 366 
SER CA  CB   sing N N 367 
SER CA  HA   sing N N 368 
SER C   O    doub N N 369 
SER C   OXT  sing N N 370 
SER CB  OG   sing N N 371 
SER CB  HB2  sing N N 372 
SER CB  HB3  sing N N 373 
SER OG  HG   sing N N 374 
SER OXT HXT  sing N N 375 
THR N   CA   sing N N 376 
THR N   H    sing N N 377 
THR N   H2   sing N N 378 
THR CA  C    sing N N 379 
THR CA  CB   sing N N 380 
THR CA  HA   sing N N 381 
THR C   O    doub N N 382 
THR C   OXT  sing N N 383 
THR CB  OG1  sing N N 384 
THR CB  CG2  sing N N 385 
THR CB  HB   sing N N 386 
THR OG1 HG1  sing N N 387 
THR CG2 HG21 sing N N 388 
THR CG2 HG22 sing N N 389 
THR CG2 HG23 sing N N 390 
THR OXT HXT  sing N N 391 
TRP N   CA   sing N N 392 
TRP N   H    sing N N 393 
TRP N   H2   sing N N 394 
TRP CA  C    sing N N 395 
TRP CA  CB   sing N N 396 
TRP CA  HA   sing N N 397 
TRP C   O    doub N N 398 
TRP C   OXT  sing N N 399 
TRP CB  CG   sing N N 400 
TRP CB  HB2  sing N N 401 
TRP CB  HB3  sing N N 402 
TRP CG  CD1  doub Y N 403 
TRP CG  CD2  sing Y N 404 
TRP CD1 NE1  sing Y N 405 
TRP CD1 HD1  sing N N 406 
TRP CD2 CE2  doub Y N 407 
TRP CD2 CE3  sing Y N 408 
TRP NE1 CE2  sing Y N 409 
TRP NE1 HE1  sing N N 410 
TRP CE2 CZ2  sing Y N 411 
TRP CE3 CZ3  doub Y N 412 
TRP CE3 HE3  sing N N 413 
TRP CZ2 CH2  doub Y N 414 
TRP CZ2 HZ2  sing N N 415 
TRP CZ3 CH2  sing Y N 416 
TRP CZ3 HZ3  sing N N 417 
TRP CH2 HH2  sing N N 418 
TRP OXT HXT  sing N N 419 
TYR N   CA   sing N N 420 
TYR N   H    sing N N 421 
TYR N   H2   sing N N 422 
TYR CA  C    sing N N 423 
TYR CA  CB   sing N N 424 
TYR CA  HA   sing N N 425 
TYR C   O    doub N N 426 
TYR C   OXT  sing N N 427 
TYR CB  CG   sing N N 428 
TYR CB  HB2  sing N N 429 
TYR CB  HB3  sing N N 430 
TYR CG  CD1  doub Y N 431 
TYR CG  CD2  sing Y N 432 
TYR CD1 CE1  sing Y N 433 
TYR CD1 HD1  sing N N 434 
TYR CD2 CE2  doub Y N 435 
TYR CD2 HD2  sing N N 436 
TYR CE1 CZ   doub Y N 437 
TYR CE1 HE1  sing N N 438 
TYR CE2 CZ   sing Y N 439 
TYR CE2 HE2  sing N N 440 
TYR CZ  OH   sing N N 441 
TYR OH  HH   sing N N 442 
TYR OXT HXT  sing N N 443 
VAL N   CA   sing N N 444 
VAL N   H    sing N N 445 
VAL N   H2   sing N N 446 
VAL CA  C    sing N N 447 
VAL CA  CB   sing N N 448 
VAL CA  HA   sing N N 449 
VAL C   O    doub N N 450 
VAL C   OXT  sing N N 451 
VAL CB  CG1  sing N N 452 
VAL CB  CG2  sing N N 453 
VAL CB  HB   sing N N 454 
VAL CG1 HG11 sing N N 455 
VAL CG1 HG12 sing N N 456 
VAL CG1 HG13 sing N N 457 
VAL CG2 HG21 sing N N 458 
VAL CG2 HG22 sing N N 459 
VAL CG2 HG23 sing N N 460 
VAL OXT HXT  sing N N 461 
# 
_pdbx_audit_support.ordinal                1 
_pdbx_audit_support.funding_organization   
'National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)' 
_pdbx_audit_support.grant_number           U19AI171292 
_pdbx_audit_support.country                'United States' 
# 
_pdbx_deposit_group.group_id            G_1002341 
_pdbx_deposit_group.group_description   
'Crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_pdbx_deposit_group.group_title         
'Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_pdbx_deposit_group.group_type          'changed state' 
# 
_atom_sites.entry_id                    7I2B 
_atom_sites.fract_transf_matrix[1][1]   0.012125 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   -0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.008557 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   -0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.006749 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
# 
loop_
_atom_type.symbol 
C  
CL 
N  
O  
P  
S  
ZN 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . ASN A 1 10  ? -13.340 -6.278  -11.950 0.50 82.12  ? 273  ASN A N   1 
ATOM   2    C  CA  . ASN A 1 10  ? -13.274 -6.965  -10.629 0.50 81.17  ? 273  ASN A CA  1 
ATOM   3    C  C   . ASN A 1 10  ? -14.656 -6.882  -9.966  0.50 79.40  ? 273  ASN A C   1 
ATOM   4    O  O   . ASN A 1 10  ? -15.625 -7.381  -10.579 0.50 75.55  ? 273  ASN A O   1 
ATOM   5    C  CB  . ASN A 1 10  ? -12.158 -6.386  -9.751  0.50 83.50  ? 273  ASN A CB  1 
ATOM   6    C  CG  . ASN A 1 10  ? -11.525 -7.413  -8.834  0.50 83.17  ? 273  ASN A CG  1 
ATOM   7    O  OD1 . ASN A 1 10  ? -12.210 -8.276  -8.290  0.50 82.59  ? 273  ASN A OD1 1 
ATOM   8    N  ND2 . ASN A 1 10  ? -10.217 -7.326  -8.651  0.50 83.02  ? 273  ASN A ND2 1 
ATOM   9    N  N   . LEU A 1 11  ? -14.743 -6.264  -8.779  0.50 75.60  ? 274  LEU A N   1 
ATOM   10   C  CA  . LEU A 1 11  ? -15.956 -6.273  -7.912  0.50 71.13  ? 274  LEU A CA  1 
ATOM   11   C  C   . LEU A 1 11  ? -17.117 -5.588  -8.639  0.50 67.59  ? 274  LEU A C   1 
ATOM   12   O  O   . LEU A 1 11  ? -18.267 -5.735  -8.182  0.50 63.80  ? 274  LEU A O   1 
ATOM   13   C  CB  . LEU A 1 11  ? -15.653 -5.580  -6.579  0.50 74.01  ? 274  LEU A CB  1 
ATOM   14   C  CG  . LEU A 1 11  ? -15.112 -6.486  -5.472  0.50 76.01  ? 274  LEU A CG  1 
ATOM   15   C  CD1 . LEU A 1 11  ? -13.589 -6.461  -5.442  0.50 76.93  ? 274  LEU A CD1 1 
ATOM   16   C  CD2 . LEU A 1 11  ? -15.678 -6.086  -4.115  0.50 76.38  ? 274  LEU A CD2 1 
ATOM   17   N  N   . ASP A 1 12  ? -16.824 -4.877  -9.730  0.50 65.41  ? 275  ASP A N   1 
ATOM   18   C  CA  . ASP A 1 12  ? -17.844 -4.204  -10.577 0.50 68.95  ? 275  ASP A CA  1 
ATOM   19   C  C   . ASP A 1 12  ? -18.716 -5.271  -11.249 0.50 67.91  ? 275  ASP A C   1 
ATOM   20   O  O   . ASP A 1 12  ? -19.779 -4.905  -11.784 0.50 65.70  ? 275  ASP A O   1 
ATOM   21   C  CB  . ASP A 1 12  ? -17.193 -3.295  -11.622 0.50 72.53  ? 275  ASP A CB  1 
ATOM   22   C  CG  . ASP A 1 12  ? -16.781 -4.027  -12.887 0.50 75.74  ? 275  ASP A CG  1 
ATOM   23   O  OD1 . ASP A 1 12  ? -16.112 -5.079  -12.766 0.50 80.74  ? 275  ASP A OD1 1 
ATOM   24   O  OD2 . ASP A 1 12  ? -17.146 -3.548  -13.982 0.50 75.95  ? 275  ASP A OD2 1 
ATOM   25   N  N   . ILE A 1 13  ? -18.279 -6.536  -11.218 0.50 66.58  ? 276  ILE A N   1 
ATOM   26   C  CA  . ILE A 1 13  ? -18.946 -7.683  -11.908 0.50 61.39  ? 276  ILE A CA  1 
ATOM   27   C  C   . ILE A 1 13  ? -19.298 -8.773  -10.888 0.50 59.21  ? 276  ILE A C   1 
ATOM   28   O  O   . ILE A 1 13  ? -20.360 -9.401  -11.054 0.50 55.29  ? 276  ILE A O   1 
ATOM   29   C  CB  . ILE A 1 13  ? -18.051 -8.229  -13.036 0.50 61.77  ? 276  ILE A CB  1 
ATOM   30   C  CG1 . ILE A 1 13  ? -17.967 -7.249  -14.210 0.50 60.17  ? 276  ILE A CG1 1 
ATOM   31   C  CG2 . ILE A 1 13  ? -18.525 -9.605  -13.479 0.50 60.97  ? 276  ILE A CG2 1 
ATOM   32   C  CD1 . ILE A 1 13  ? -16.926 -7.612  -15.242 0.50 58.47  ? 276  ILE A CD1 1 
ATOM   33   N  N   . ILE A 1 14  ? -18.449 -8.981  -9.876  0.50 59.27  ? 277  ILE A N   1 
ATOM   34   C  CA  . ILE A 1 14  ? -18.592 -10.079 -8.871  0.50 62.48  ? 277  ILE A CA  1 
ATOM   35   C  C   . ILE A 1 14  ? -19.169 -9.522  -7.562  0.50 64.76  ? 277  ILE A C   1 
ATOM   36   O  O   . ILE A 1 14  ? -19.729 -10.320 -6.782  0.50 64.42  ? 277  ILE A O   1 
ATOM   37   C  CB  . ILE A 1 14  ? -17.242 -10.792 -8.646  0.50 63.77  ? 277  ILE A CB  1 
ATOM   38   C  CG1 . ILE A 1 14  ? -16.170 -9.835  -8.119  0.50 64.99  ? 277  ILE A CG1 1 
ATOM   39   C  CG2 . ILE A 1 14  ? -16.787 -11.496 -9.916  0.50 62.70  ? 277  ILE A CG2 1 
ATOM   40   C  CD1 . ILE A 1 14  ? -14.845 -10.505 -7.818  0.50 65.24  ? 277  ILE A CD1 1 
ATOM   41   N  N   . GLY A 1 15  ? -19.042 -8.214  -7.323  0.50 69.13  ? 278  GLY A N   1 
ATOM   42   C  CA  . GLY A 1 15  ? -19.484 -7.605  -6.049  0.50 68.67  ? 278  GLY A CA  1 
ATOM   43   C  C   . GLY A 1 15  ? -20.900 -7.966  -5.640  0.50 69.56  ? 278  GLY A C   1 
ATOM   44   O  O   . GLY A 1 15  ? -21.083 -8.360  -4.479  0.50 71.79  ? 278  GLY A O   1 
ATOM   45   N  N   . LYS A 1 16  ? -21.868 -7.835  -6.549  0.50 72.34  ? 279  LYS A N   1 
ATOM   46   C  CA  . LYS A 1 16  ? -23.293 -8.078  -6.202  0.50 74.69  ? 279  LYS A CA  1 
ATOM   47   C  C   . LYS A 1 16  ? -23.462 -9.492  -5.638  0.50 75.33  ? 279  LYS A C   1 
ATOM   48   O  O   . LYS A 1 16  ? -24.102 -9.631  -4.583  0.50 71.72  ? 279  LYS A O   1 
ATOM   49   C  CB  . LYS A 1 16  ? -24.153 -7.843  -7.447  0.50 78.16  ? 279  LYS A CB  1 
ATOM   50   C  CG  . LYS A 1 16  ? -25.655 -8.035  -7.287  0.50 81.27  ? 279  LYS A CG  1 
ATOM   51   C  CD  . LYS A 1 16  ? -26.405 -7.729  -8.569  0.50 83.02  ? 279  LYS A CD  1 
ATOM   52   C  CE  . LYS A 1 16  ? -27.909 -7.839  -8.443  0.50 84.01  ? 279  LYS A CE  1 
ATOM   53   N  NZ  . LYS A 1 16  ? -28.448 -6.899  -7.433  0.50 85.95  ? 279  LYS A NZ  1 
ATOM   54   N  N   . ARG A 1 17  ? -22.900 -10.497 -6.313  0.50 76.76  ? 280  ARG A N   1 
ATOM   55   C  CA  . ARG A 1 17  ? -22.978 -11.894 -5.813  0.50 77.48  ? 280  ARG A CA  1 
ATOM   56   C  C   . ARG A 1 17  ? -22.354 -11.948 -4.419  0.50 78.60  ? 280  ARG A C   1 
ATOM   57   O  O   . ARG A 1 17  ? -22.934 -12.603 -3.534  0.50 77.49  ? 280  ARG A O   1 
ATOM   58   C  CB  . ARG A 1 17  ? -22.244 -12.837 -6.771  0.50 76.66  ? 280  ARG A CB  1 
ATOM   59   C  CG  . ARG A 1 17  ? -23.070 -13.285 -7.967  0.50 74.91  ? 280  ARG A CG  1 
ATOM   60   C  CD  . ARG A 1 17  ? -22.245 -14.019 -9.007  0.50 71.07  ? 280  ARG A CD  1 
ATOM   61   N  NE  . ARG A 1 17  ? -21.523 -13.097 -9.870  0.50 70.32  ? 280  ARG A NE  1 
ATOM   62   C  CZ  . ARG A 1 17  ? -20.725 -13.460 -10.865 0.50 69.29  ? 280  ARG A CZ  1 
ATOM   63   N  NH1 . ARG A 1 17  ? -20.534 -14.741 -11.128 0.50 69.00  ? 280  ARG A NH1 1 
ATOM   64   N  NH2 . ARG A 1 17  ? -20.119 -12.541 -11.594 0.50 69.31  ? 280  ARG A NH2 1 
ATOM   65   N  N   . ILE A 1 18  ? -21.222 -11.268 -4.240  0.50 82.76  ? 281  ILE A N   1 
ATOM   66   C  CA  . ILE A 1 18  ? -20.513 -11.267 -2.928  0.50 84.78  ? 281  ILE A CA  1 
ATOM   67   C  C   . ILE A 1 18  ? -21.401 -10.576 -1.887  0.50 85.30  ? 281  ILE A C   1 
ATOM   68   O  O   . ILE A 1 18  ? -21.561 -11.132 -0.784  0.50 78.33  ? 281  ILE A O   1 
ATOM   69   C  CB  . ILE A 1 18  ? -19.142 -10.581 -3.079  0.50 89.02  ? 281  ILE A CB  1 
ATOM   70   C  CG1 . ILE A 1 18  ? -18.270 -11.291 -4.117  0.50 89.73  ? 281  ILE A CG1 1 
ATOM   71   C  CG2 . ILE A 1 18  ? -18.439 -10.470 -1.735  0.50 89.94  ? 281  ILE A CG2 1 
ATOM   72   C  CD1 . ILE A 1 18  ? -16.963 -10.592 -4.403  0.50 90.10  ? 281  ILE A CD1 1 
ATOM   73   N  N   . GLU A 1 19  ? -21.987 -9.431  -2.244  0.50 87.25  ? 282  GLU A N   1 
ATOM   74   C  CA  . GLU A 1 19  ? -22.841 -8.676  -1.289  0.50 90.81  ? 282  GLU A CA  1 
ATOM   75   C  C   . GLU A 1 19  ? -24.018 -9.551  -0.863  0.50 89.84  ? 282  GLU A C   1 
ATOM   76   O  O   . GLU A 1 19  ? -24.289 -9.619  0.345   0.50 91.84  ? 282  GLU A O   1 
ATOM   77   C  CB  . GLU A 1 19  ? -23.359 -7.393  -1.934  0.50 94.37  ? 282  GLU A CB  1 
ATOM   78   C  CG  . GLU A 1 19  ? -22.257 -6.471  -2.421  0.50 97.88  ? 282  GLU A CG  1 
ATOM   79   C  CD  . GLU A 1 19  ? -22.743 -5.286  -3.236  0.50 100.92 ? 282  GLU A CD  1 
ATOM   80   O  OE1 . GLU A 1 19  ? -23.966 -5.181  -3.453  0.50 105.04 ? 282  GLU A OE1 1 
ATOM   81   O  OE2 . GLU A 1 19  ? -21.897 -4.471  -3.654  0.50 99.90  ? 282  GLU A OE2 1 
ATOM   82   N  N   . LYS A 1 20  ? -24.676 -10.203 -1.823  0.50 88.10  ? 283  LYS A N   1 
ATOM   83   C  CA  . LYS A 1 20  ? -25.880 -11.006 -1.494  0.50 88.60  ? 283  LYS A CA  1 
ATOM   84   C  C   . LYS A 1 20  ? -25.495 -12.067 -0.468  0.50 90.31  ? 283  LYS A C   1 
ATOM   85   O  O   . LYS A 1 20  ? -26.205 -12.195 0.544   0.50 93.54  ? 283  LYS A O   1 
ATOM   86   C  CB  . LYS A 1 20  ? -26.450 -11.654 -2.758  0.50 89.30  ? 283  LYS A CB  1 
ATOM   87   C  CG  . LYS A 1 20  ? -27.675 -12.534 -2.558  0.50 89.81  ? 283  LYS A CG  1 
ATOM   88   C  CD  . LYS A 1 20  ? -28.300 -12.967 -3.867  0.50 91.80  ? 283  LYS A CD  1 
ATOM   89   C  CE  . LYS A 1 20  ? -29.556 -13.792 -3.690  0.50 90.97  ? 283  LYS A CE  1 
ATOM   90   N  NZ  . LYS A 1 20  ? -29.272 -15.096 -3.047  0.50 92.13  ? 283  LYS A NZ  1 
ATOM   91   N  N   . ILE A 1 21  ? -24.393 -12.773 -0.710  0.50 90.00  ? 284  ILE A N   1 
ATOM   92   C  CA  . ILE A 1 21  ? -23.987 -13.876 0.207   0.50 91.43  ? 284  ILE A CA  1 
ATOM   93   C  C   . ILE A 1 21  ? -23.688 -13.278 1.583   0.50 89.43  ? 284  ILE A C   1 
ATOM   94   O  O   . ILE A 1 21  ? -24.167 -13.835 2.587   0.50 84.28  ? 284  ILE A O   1 
ATOM   95   C  CB  . ILE A 1 21  ? -22.769 -14.626 -0.364  0.50 93.20  ? 284  ILE A CB  1 
ATOM   96   C  CG1 . ILE A 1 21  ? -23.069 -15.221 -1.742  0.50 94.11  ? 284  ILE A CG1 1 
ATOM   97   C  CG2 . ILE A 1 21  ? -22.277 -15.682 0.613   0.50 92.89  ? 284  ILE A CG2 1 
ATOM   98   C  CD1 . ILE A 1 21  ? -21.861 -15.803 -2.437  0.50 93.58  ? 284  ILE A CD1 1 
ATOM   99   N  N   . LYS A 1 22  ? -22.938 -12.177 1.614   0.50 88.07  ? 285  LYS A N   1 
ATOM   100  C  CA  . LYS A 1 22  ? -22.545 -11.559 2.906   0.50 89.29  ? 285  LYS A CA  1 
ATOM   101  C  C   . LYS A 1 22  ? -23.801 -11.186 3.697   0.50 84.86  ? 285  LYS A C   1 
ATOM   102  O  O   . LYS A 1 22  ? -23.885 -11.564 4.875   0.50 76.27  ? 285  LYS A O   1 
ATOM   103  C  CB  . LYS A 1 22  ? -21.673 -10.331 2.638   0.50 93.57  ? 285  LYS A CB  1 
ATOM   104  C  CG  . LYS A 1 22  ? -21.259 -9.542  3.872   0.50 97.07  ? 285  LYS A CG  1 
ATOM   105  C  CD  . LYS A 1 22  ? -20.512 -8.272  3.531   0.50 98.74  ? 285  LYS A CD  1 
ATOM   106  C  CE  . LYS A 1 22  ? -20.216 -7.416  4.743   0.50 99.92  ? 285  LYS A CE  1 
ATOM   107  N  NZ  . LYS A 1 22  ? -19.620 -6.114  4.361   0.50 100.51 ? 285  LYS A NZ  1 
ATOM   108  N  N   . GLN A 1 23  ? -24.749 -10.502 3.055   0.50 83.69  ? 286  GLN A N   1 
ATOM   109  C  CA  . GLN A 1 23  ? -25.984 -10.053 3.753   0.50 84.17  ? 286  GLN A CA  1 
ATOM   110  C  C   . GLN A 1 23  ? -26.734 -11.263 4.323   0.50 81.73  ? 286  GLN A C   1 
ATOM   111  O  O   . GLN A 1 23  ? -27.424 -11.095 5.342   0.50 84.31  ? 286  GLN A O   1 
ATOM   112  C  CB  . GLN A 1 23  ? -26.861 -9.251  2.792   0.50 85.79  ? 286  GLN A CB  1 
ATOM   113  C  CG  . GLN A 1 23  ? -26.172 -8.009  2.252   0.50 87.98  ? 286  GLN A CG  1 
ATOM   114  C  CD  . GLN A 1 23  ? -27.059 -7.222  1.320   0.50 91.29  ? 286  GLN A CD  1 
ATOM   115  O  OE1 . GLN A 1 23  ? -28.172 -7.633  0.998   0.50 93.58  ? 286  GLN A OE1 1 
ATOM   116  N  NE2 . GLN A 1 23  ? -26.567 -6.077  0.878   0.50 93.26  ? 286  GLN A NE2 1 
ATOM   117  N  N   . GLU A 1 24  ? -26.613 -12.429 3.687   0.50 77.33  ? 287  GLU A N   1 
ATOM   118  C  CA  . GLU A 1 24  ? -27.341 -13.638 4.152   0.50 76.52  ? 287  GLU A CA  1 
ATOM   119  C  C   . GLU A 1 24  ? -26.557 -14.293 5.292   0.50 74.55  ? 287  GLU A C   1 
ATOM   120  O  O   . GLU A 1 24  ? -27.042 -15.305 5.830   0.50 73.38  ? 287  GLU A O   1 
ATOM   121  C  CB  . GLU A 1 24  ? -27.536 -14.616 2.993   0.50 78.19  ? 287  GLU A CB  1 
ATOM   122  C  CG  . GLU A 1 24  ? -28.296 -14.016 1.826   0.50 79.94  ? 287  GLU A CG  1 
ATOM   123  C  CD  . GLU A 1 24  ? -28.127 -14.742 0.503   0.50 81.10  ? 287  GLU A CD  1 
ATOM   124  O  OE1 . GLU A 1 24  ? -28.914 -14.464 -0.421  0.50 82.24  ? 287  GLU A OE1 1 
ATOM   125  O  OE2 . GLU A 1 24  ? -27.206 -15.575 0.397   0.50 79.52  ? 287  GLU A OE2 1 
ATOM   126  N  N   . HIS A 1 25  ? -25.391 -13.739 5.633   0.50 76.22  ? 288  HIS A N   1 
ATOM   127  C  CA  . HIS A 1 25  ? -24.540 -14.324 6.705   0.50 77.81  ? 288  HIS A CA  1 
ATOM   128  C  C   . HIS A 1 25  ? -23.811 -13.212 7.470   0.50 79.16  ? 288  HIS A C   1 
ATOM   129  O  O   . HIS A 1 25  ? -22.756 -13.508 8.064   0.50 76.07  ? 288  HIS A O   1 
ATOM   130  C  CB  . HIS A 1 25  ? -23.557 -15.337 6.102   0.50 74.66  ? 288  HIS A CB  1 
ATOM   131  C  CG  . HIS A 1 25  ? -24.207 -16.423 5.314   0.50 74.09  ? 288  HIS A CG  1 
ATOM   132  N  ND1 . HIS A 1 25  ? -24.882 -17.466 5.913   0.50 76.11  ? 288  HIS A ND1 1 
ATOM   133  C  CD2 . HIS A 1 25  ? -24.280 -16.639 3.983   0.50 72.46  ? 288  HIS A CD2 1 
ATOM   134  C  CE1 . HIS A 1 25  ? -25.349 -18.276 4.985   0.50 74.13  ? 288  HIS A CE1 1 
ATOM   135  N  NE2 . HIS A 1 25  ? -24.993 -17.790 3.793   0.50 70.88  ? 288  HIS A NE2 1 
ATOM   136  N  N   . GLU A 1 26  ? -24.340 -11.985 7.450   0.50 81.02  ? 289  GLU A N   1 
ATOM   137  C  CA  . GLU A 1 26  ? -23.640 -10.838 8.098   0.50 82.85  ? 289  GLU A CA  1 
ATOM   138  C  C   . GLU A 1 26  ? -23.475 -11.134 9.594   0.50 85.47  ? 289  GLU A C   1 
ATOM   139  O  O   . GLU A 1 26  ? -22.753 -10.380 10.268  0.50 82.18  ? 289  GLU A O   1 
ATOM   140  C  CB  . GLU A 1 26  ? -24.419 -9.546  7.846   0.50 81.28  ? 289  GLU A CB  1 
ATOM   141  C  CG  . GLU A 1 26  ? -23.562 -8.298  7.939   0.50 80.00  ? 289  GLU A CG  1 
ATOM   142  C  CD  . GLU A 1 26  ? -23.897 -7.227  6.915   0.50 78.21  ? 289  GLU A CD  1 
ATOM   143  O  OE1 . GLU A 1 26  ? -23.324 -6.125  7.008   0.50 77.65  ? 289  GLU A OE1 1 
ATOM   144  O  OE2 . GLU A 1 26  ? -24.722 -7.501  6.022   0.50 74.41  ? 289  GLU A OE2 1 
ATOM   145  N  N   . THR A 1 27  ? -24.107 -12.200 10.077  0.50 90.33  ? 290  THR A N   1 
ATOM   146  C  CA  . THR A 1 27  ? -24.051 -12.606 11.508  0.50 93.96  ? 290  THR A CA  1 
ATOM   147  C  C   . THR A 1 27  ? -22.883 -13.575 11.734  0.50 94.22  ? 290  THR A C   1 
ATOM   148  O  O   . THR A 1 27  ? -22.810 -14.140 12.844  0.50 96.65  ? 290  THR A O   1 
ATOM   149  C  CB  . THR A 1 27  ? -25.368 -13.250 11.965  0.50 97.79  ? 290  THR A CB  1 
ATOM   150  O  OG1 . THR A 1 27  ? -25.732 -14.256 11.019  0.50 101.29 ? 290  THR A OG1 1 
ATOM   151  C  CG2 . THR A 1 27  ? -26.502 -12.257 12.102  0.50 97.89  ? 290  THR A CG2 1 
ATOM   152  N  N   . SER A 1 28  ? -22.014 -13.762 10.731  0.50 91.53  ? 291  SER A N   1 
ATOM   153  C  CA  . SER A 1 28  ? -20.868 -14.713 10.771  0.50 86.85  ? 291  SER A CA  1 
ATOM   154  C  C   . SER A 1 28  ? -19.754 -14.282 9.807   0.50 85.65  ? 291  SER A C   1 
ATOM   155  O  O   . SER A 1 28  ? -18.826 -15.086 9.598   0.50 84.40  ? 291  SER A O   1 
ATOM   156  C  CB  . SER A 1 28  ? -21.321 -16.120 10.461  0.50 86.90  ? 291  SER A CB  1 
ATOM   157  O  OG  . SER A 1 28  ? -22.141 -16.640 11.499  0.50 84.97  ? 291  SER A OG  1 
ATOM   158  N  N   . TRP A 1 29  ? -19.829 -13.070 9.248   0.50 84.98  ? 292  TRP A N   1 
ATOM   159  C  CA  . TRP A 1 29  ? -18.890 -12.585 8.198   0.50 86.71  ? 292  TRP A CA  1 
ATOM   160  C  C   . TRP A 1 29  ? -17.546 -12.195 8.826   0.50 86.58  ? 292  TRP A C   1 
ATOM   161  O  O   . TRP A 1 29  ? -17.439 -11.060 9.330   0.50 88.93  ? 292  TRP A O   1 
ATOM   162  C  CB  . TRP A 1 29  ? -19.497 -11.418 7.410   0.50 83.28  ? 292  TRP A CB  1 
ATOM   163  C  CG  . TRP A 1 29  ? -18.848 -11.201 6.077   0.50 83.42  ? 292  TRP A CG  1 
ATOM   164  C  CD1 . TRP A 1 29  ? -18.075 -10.143 5.692   0.50 85.04  ? 292  TRP A CD1 1 
ATOM   165  C  CD2 . TRP A 1 29  ? -18.904 -12.086 4.944   0.50 81.20  ? 292  TRP A CD2 1 
ATOM   166  N  NE1 . TRP A 1 29  ? -17.656 -10.303 4.399   0.50 82.84  ? 292  TRP A NE1 1 
ATOM   167  C  CE2 . TRP A 1 29  ? -18.148 -11.487 3.914   0.50 82.19  ? 292  TRP A CE2 1 
ATOM   168  C  CE3 . TRP A 1 29  ? -19.520 -13.318 4.701   0.50 80.30  ? 292  TRP A CE3 1 
ATOM   169  C  CZ2 . TRP A 1 29  ? -17.999 -12.082 2.662   0.50 81.15  ? 292  TRP A CZ2 1 
ATOM   170  C  CZ3 . TRP A 1 29  ? -19.368 -13.905 3.465   0.50 79.57  ? 292  TRP A CZ3 1 
ATOM   171  C  CH2 . TRP A 1 29  ? -18.619 -13.293 2.461   0.50 79.11  ? 292  TRP A CH2 1 
ATOM   172  N  N   . HIS A 1 30  ? -16.556 -13.094 8.771   0.50 85.97  ? 293  HIS A N   1 
ATOM   173  C  CA  . HIS A 1 30  ? -15.184 -12.872 9.304   0.50 85.38  ? 293  HIS A CA  1 
ATOM   174  C  C   . HIS A 1 30  ? -14.158 -12.985 8.171   0.50 87.89  ? 293  HIS A C   1 
ATOM   175  O  O   . HIS A 1 30  ? -14.157 -14.018 7.481   0.50 90.14  ? 293  HIS A O   1 
ATOM   176  C  CB  . HIS A 1 30  ? -14.890 -13.825 10.473  0.50 81.98  ? 293  HIS A CB  1 
ATOM   177  C  CG  . HIS A 1 30  ? -15.049 -15.279 10.170  0.50 78.22  ? 293  HIS A CG  1 
ATOM   178  N  ND1 . HIS A 1 30  ? -16.286 -15.890 10.100  0.50 75.11  ? 293  HIS A ND1 1 
ATOM   179  C  CD2 . HIS A 1 30  ? -14.134 -16.254 9.969   0.50 76.23  ? 293  HIS A CD2 1 
ATOM   180  C  CE1 . HIS A 1 30  ? -16.127 -17.173 9.845   0.50 75.42  ? 293  HIS A CE1 1 
ATOM   181  N  NE2 . HIS A 1 30  ? -14.815 -17.422 9.760   0.50 75.99  ? 293  HIS A NE2 1 
ATOM   182  N  N   . TYR A 1 31  ? -13.331 -11.948 7.996   0.50 91.53  ? 294  TYR A N   1 
ATOM   183  C  CA  . TYR A 1 31  ? -12.247 -11.867 6.981   0.50 95.56  ? 294  TYR A CA  1 
ATOM   184  C  C   . TYR A 1 31  ? -10.985 -12.545 7.527   0.50 95.75  ? 294  TYR A C   1 
ATOM   185  O  O   . TYR A 1 31  ? -9.969  -11.850 7.732   0.50 97.27  ? 294  TYR A O   1 
ATOM   186  C  CB  . TYR A 1 31  ? -11.964 -10.410 6.601   0.50 98.67  ? 294  TYR A CB  1 
ATOM   187  C  CG  . TYR A 1 31  ? -11.012 -10.240 5.443   0.50 105.07 ? 294  TYR A CG  1 
ATOM   188  C  CD1 . TYR A 1 31  ? -11.449 -10.373 4.135   0.50 106.53 ? 294  TYR A CD1 1 
ATOM   189  C  CD2 . TYR A 1 31  ? -9.673  -9.950  5.649   0.50 106.57 ? 294  TYR A CD2 1 
ATOM   190  C  CE1 . TYR A 1 31  ? -10.585 -10.221 3.063   0.50 106.09 ? 294  TYR A CE1 1 
ATOM   191  C  CE2 . TYR A 1 31  ? -8.794  -9.795  4.589   0.50 106.02 ? 294  TYR A CE2 1 
ATOM   192  C  CZ  . TYR A 1 31  ? -9.252  -9.932  3.291   0.50 105.81 ? 294  TYR A CZ  1 
ATOM   193  O  OH  . TYR A 1 31  ? -8.397  -9.783  2.238   0.50 105.23 ? 294  TYR A OH  1 
ATOM   194  N  N   . ASP A 1 32  ? -11.058 -13.863 7.743   0.50 95.31  ? 295  ASP A N   1 
ATOM   195  C  CA  . ASP A 1 32  ? -9.966  -14.712 8.297   0.50 95.68  ? 295  ASP A CA  1 
ATOM   196  C  C   . ASP A 1 32  ? -8.631  -14.342 7.635   0.50 98.01  ? 295  ASP A C   1 
ATOM   197  O  O   . ASP A 1 32  ? -8.536  -14.432 6.393   0.50 96.82  ? 295  ASP A O   1 
ATOM   198  C  CB  . ASP A 1 32  ? -10.291 -16.198 8.115   0.50 91.80  ? 295  ASP A CB  1 
ATOM   199  C  CG  . ASP A 1 32  ? -9.327  -17.125 8.832   0.50 89.35  ? 295  ASP A CG  1 
ATOM   200  O  OD1 . ASP A 1 32  ? -8.268  -16.637 9.273   0.50 88.78  ? 295  ASP A OD1 1 
ATOM   201  O  OD2 . ASP A 1 32  ? -9.645  -18.324 8.946   0.50 86.62  ? 295  ASP A OD2 1 
ATOM   202  N  N   . GLN A 1 33  ? -7.638  -13.953 8.444   0.50 97.95  ? 296  GLN A N   1 
ATOM   203  C  CA  . GLN A 1 33  ? -6.293  -13.509 7.986   0.50 98.32  ? 296  GLN A CA  1 
ATOM   204  C  C   . GLN A 1 33  ? -5.344  -14.713 7.951   0.50 97.19  ? 296  GLN A C   1 
ATOM   205  O  O   . GLN A 1 33  ? -4.157  -14.520 7.620   0.50 99.32  ? 296  GLN A O   1 
ATOM   206  C  CB  . GLN A 1 33  ? -5.742  -12.416 8.905   0.50 99.00  ? 296  GLN A CB  1 
ATOM   207  C  CG  . GLN A 1 33  ? -6.575  -11.143 8.915   0.50 99.82  ? 296  GLN A CG  1 
ATOM   208  C  CD  . GLN A 1 33  ? -6.571  -10.442 7.578   0.50 100.86 ? 296  GLN A CD  1 
ATOM   209  O  OE1 . GLN A 1 33  ? -6.148  -10.995 6.565   0.50 101.44 ? 296  GLN A OE1 1 
ATOM   210  N  NE2 . GLN A 1 33  ? -7.049  -9.208  7.566   0.50 100.29 ? 296  GLN A NE2 1 
ATOM   211  N  N   . ASP A 1 34  ? -5.853  -15.902 8.291   0.50 94.22  ? 297  ASP A N   1 
ATOM   212  C  CA  . ASP A 1 34  ? -5.104  -17.186 8.248   0.50 93.19  ? 297  ASP A CA  1 
ATOM   213  C  C   . ASP A 1 34  ? -5.467  -17.937 6.961   0.50 93.87  ? 297  ASP A C   1 
ATOM   214  O  O   . ASP A 1 34  ? -5.007  -19.087 6.804   0.50 92.38  ? 297  ASP A O   1 
ATOM   215  C  CB  . ASP A 1 34  ? -5.400  -18.048 9.479   0.50 92.80  ? 297  ASP A CB  1 
ATOM   216  C  CG  . ASP A 1 34  ? -4.707  -17.582 10.749  0.50 92.32  ? 297  ASP A CG  1 
ATOM   217  O  OD1 . ASP A 1 34  ? -3.592  -17.029 10.642  0.50 92.11  ? 297  ASP A OD1 1 
ATOM   218  O  OD2 . ASP A 1 34  ? -5.288  -17.779 11.833  0.50 90.27  ? 297  ASP A OD2 1 
ATOM   219  N  N   . HIS A 1 35  ? -6.259  -17.307 6.083   0.50 93.95  ? 298  HIS A N   1 
ATOM   220  C  CA  . HIS A 1 35  ? -6.825  -17.920 4.849   0.50 88.13  ? 298  HIS A CA  1 
ATOM   221  C  C   . HIS A 1 35  ? -5.687  -18.438 3.971   0.50 86.68  ? 298  HIS A C   1 
ATOM   222  O  O   . HIS A 1 35  ? -4.719  -17.720 3.724   0.50 82.49  ? 298  HIS A O   1 
ATOM   223  C  CB  . HIS A 1 35  ? -7.749  -16.934 4.114   0.50 85.61  ? 298  HIS A CB  1 
ATOM   224  C  CG  . HIS A 1 35  ? -7.052  -15.831 3.386   0.50 84.09  ? 298  HIS A CG  1 
ATOM   225  N  ND1 . HIS A 1 35  ? -7.200  -14.502 3.742   0.50 83.52  ? 298  HIS A ND1 1 
ATOM   226  C  CD2 . HIS A 1 35  ? -6.234  -15.843 2.310   0.50 81.56  ? 298  HIS A CD2 1 
ATOM   227  C  CE1 . HIS A 1 35  ? -6.492  -13.747 2.926   0.50 81.57  ? 298  HIS A CE1 1 
ATOM   228  N  NE2 . HIS A 1 35  ? -5.889  -14.546 2.040   0.50 81.49  ? 298  HIS A NE2 1 
ATOM   229  N  N   . PRO A 1 36  ? -5.765  -19.699 3.478   1.00 85.23  ? 299  PRO A N   1 
ATOM   230  C  CA  . PRO A 1 36  ? -4.678  -20.276 2.679   1.00 82.21  ? 299  PRO A CA  1 
ATOM   231  C  C   . PRO A 1 36  ? -4.474  -19.779 1.234   1.00 87.57  ? 299  PRO A C   1 
ATOM   232  O  O   . PRO A 1 36  ? -3.415  -20.009 0.691   1.00 96.64  ? 299  PRO A O   1 
ATOM   233  C  CB  . PRO A 1 36  ? -5.074  -21.761 2.637   1.00 82.15  ? 299  PRO A CB  1 
ATOM   234  C  CG  . PRO A 1 36  ? -6.586  -21.765 2.736   1.00 83.49  ? 299  PRO A CG  1 
ATOM   235  C  CD  . PRO A 1 36  ? -6.902  -20.620 3.666   1.00 82.82  ? 299  PRO A CD  1 
ATOM   236  N  N   . TYR A 1 37  ? -5.465  -19.125 0.631   1.00 87.02  ? 300  TYR A N   1 
ATOM   237  C  CA  . TYR A 1 37  ? -5.506  -18.870 -0.834  1.00 82.23  ? 300  TYR A CA  1 
ATOM   238  C  C   . TYR A 1 37  ? -4.365  -17.920 -1.198  1.00 80.07  ? 300  TYR A C   1 
ATOM   239  O  O   . TYR A 1 37  ? -4.258  -16.856 -0.562  1.00 83.09  ? 300  TYR A O   1 
ATOM   240  C  CB  . TYR A 1 37  ? -6.896  -18.377 -1.257  1.00 76.38  ? 300  TYR A CB  1 
ATOM   241  C  CG  . TYR A 1 37  ? -8.000  -19.211 -0.661  1.00 65.42  ? 300  TYR A CG  1 
ATOM   242  C  CD1 . TYR A 1 37  ? -8.237  -20.503 -1.094  1.00 66.39  ? 300  TYR A CD1 1 
ATOM   243  C  CD2 . TYR A 1 37  ? -8.743  -18.745 0.405   1.00 64.37  ? 300  TYR A CD2 1 
ATOM   244  C  CE1 . TYR A 1 37  ? -9.209  -21.297 -0.511  1.00 62.73  ? 300  TYR A CE1 1 
ATOM   245  C  CE2 . TYR A 1 37  ? -9.718  -19.523 1.000   1.00 60.22  ? 300  TYR A CE2 1 
ATOM   246  C  CZ  . TYR A 1 37  ? -9.959  -20.794 0.533   1.00 54.48  ? 300  TYR A CZ  1 
ATOM   247  O  OH  . TYR A 1 37  ? -10.908 -21.556 1.129   1.00 70.67  ? 300  TYR A OH  1 
ATOM   248  N  N   . LYS A 1 38  ? -3.532  -18.331 -2.162  1.00 75.52  ? 301  LYS A N   1 
ATOM   249  C  CA  . LYS A 1 38  ? -2.502  -17.479 -2.816  1.00 79.02  ? 301  LYS A CA  1 
ATOM   250  C  C   . LYS A 1 38  ? -3.017  -16.922 -4.151  1.00 83.38  ? 301  LYS A C   1 
ATOM   251  O  O   . LYS A 1 38  ? -2.938  -15.690 -4.334  1.00 79.82  ? 301  LYS A O   1 
ATOM   252  C  CB  . LYS A 1 38  ? -1.201  -18.247 -3.073  1.00 79.02  ? 301  LYS A CB  1 
ATOM   253  C  CG  . LYS A 1 38  ? -0.046  -17.394 -3.592  1.00 86.48  ? 301  LYS A CG  1 
ATOM   254  C  CD  . LYS A 1 38  ? 0.132   -16.069 -2.857  1.00 84.48  ? 301  LYS A CD  1 
ATOM   255  C  CE  . LYS A 1 38  ? 1.166   -15.161 -3.488  1.00 92.61  ? 301  LYS A CE  1 
ATOM   256  N  NZ  . LYS A 1 38  ? 2.453   -15.198 -2.754  1.00 100.16 ? 301  LYS A NZ  1 
ATOM   257  N  N   . THR A 1 39  ? -3.487  -17.777 -5.070  1.00 79.49  ? 302  THR A N   1 
ATOM   258  C  CA  . THR A 1 39  ? -3.810  -17.372 -6.470  1.00 76.16  ? 302  THR A CA  1 
ATOM   259  C  C   . THR A 1 39  ? -5.311  -17.121 -6.661  1.00 68.21  ? 302  THR A C   1 
ATOM   260  O  O   . THR A 1 39  ? -5.658  -16.556 -7.701  1.00 65.97  ? 302  THR A O   1 
ATOM   261  C  CB  . THR A 1 39  ? -3.327  -18.417 -7.472  1.00 71.27  ? 302  THR A CB  1 
ATOM   262  O  OG1 . THR A 1 39  ? -4.177  -19.534 -7.230  1.00 65.11  ? 302  THR A OG1 1 
ATOM   263  C  CG2 . THR A 1 39  ? -1.859  -18.745 -7.305  1.00 72.44  ? 302  THR A CG2 1 
ATOM   264  N  N   . TRP A 1 40  ? -6.124  -17.547 -5.690  1.00 65.29  ? 303  TRP A N   1 
ATOM   265  C  CA  . TRP A 1 40  ? -7.574  -17.243 -5.686  1.00 64.76  ? 303  TRP A CA  1 
ATOM   266  C  C   . TRP A 1 40  ? -7.761  -16.011 -4.802  1.00 69.89  ? 303  TRP A C   1 
ATOM   267  O  O   . TRP A 1 40  ? -7.139  -15.977 -3.730  1.00 70.41  ? 303  TRP A O   1 
ATOM   268  C  CB  . TRP A 1 40  ? -8.366  -18.414 -5.103  1.00 67.86  ? 303  TRP A CB  1 
ATOM   269  C  CG  . TRP A 1 40  ? -8.574  -19.605 -5.980  1.00 65.23  ? 303  TRP A CG  1 
ATOM   270  C  CD1 . TRP A 1 40  ? -7.697  -20.620 -6.225  1.00 68.92  ? 303  TRP A CD1 1 
ATOM   271  C  CD2 . TRP A 1 40  ? -9.784  -19.942 -6.675  1.00 68.38  ? 303  TRP A CD2 1 
ATOM   272  N  NE1 . TRP A 1 40  ? -8.269  -21.548 -7.053  1.00 72.26  ? 303  TRP A NE1 1 
ATOM   273  C  CE2 . TRP A 1 40  ? -9.549  -21.160 -7.344  1.00 72.86  ? 303  TRP A CE2 1 
ATOM   274  C  CE3 . TRP A 1 40  ? -11.031 -19.325 -6.809  1.00 64.88  ? 303  TRP A CE3 1 
ATOM   275  C  CZ2 . TRP A 1 40  ? -10.520 -21.769 -8.135  1.00 72.46  ? 303  TRP A CZ2 1 
ATOM   276  C  CZ3 . TRP A 1 40  ? -11.989 -19.929 -7.589  1.00 73.69  ? 303  TRP A CZ3 1 
ATOM   277  C  CH2 . TRP A 1 40  ? -11.735 -21.134 -8.241  1.00 67.95  ? 303  TRP A CH2 1 
ATOM   278  N  N   . ALA A 1 41  ? -8.583  -15.049 -5.220  1.00 69.39  ? 304  ALA A N   1 
ATOM   279  C  CA  . ALA A 1 41  ? -8.862  -13.859 -4.385  1.00 71.32  ? 304  ALA A CA  1 
ATOM   280  C  C   . ALA A 1 41  ? -9.858  -14.223 -3.287  1.00 74.39  ? 304  ALA A C   1 
ATOM   281  O  O   . ALA A 1 41  ? -10.886 -14.827 -3.608  1.00 71.75  ? 304  ALA A O   1 
ATOM   282  C  CB  . ALA A 1 41  ? -9.375  -12.719 -5.223  1.00 64.41  ? 304  ALA A CB  1 
ATOM   283  N  N   . TYR A 1 42  ? -9.543  -13.861 -2.041  0.50 76.23  ? 305  TYR A N   1 
ATOM   284  C  CA  . TYR A 1 42  ? -10.423 -14.168 -0.884  0.50 74.45  ? 305  TYR A CA  1 
ATOM   285  C  C   . TYR A 1 42  ? -11.270 -12.935 -0.571  0.50 73.22  ? 305  TYR A C   1 
ATOM   286  O  O   . TYR A 1 42  ? -10.786 -11.809 -0.778  0.50 74.30  ? 305  TYR A O   1 
ATOM   287  C  CB  . TYR A 1 42  ? -9.573  -14.599 0.313   0.50 73.91  ? 305  TYR A CB  1 
ATOM   288  C  CG  . TYR A 1 42  ? -10.299 -14.718 1.628   0.50 72.73  ? 305  TYR A CG  1 
ATOM   289  C  CD1 . TYR A 1 42  ? -11.006 -15.862 1.955   0.50 69.96  ? 305  TYR A CD1 1 
ATOM   290  C  CD2 . TYR A 1 42  ? -10.253 -13.696 2.561   0.50 71.41  ? 305  TYR A CD2 1 
ATOM   291  C  CE1 . TYR A 1 42  ? -11.663 -15.981 3.167   0.50 70.54  ? 305  TYR A CE1 1 
ATOM   292  C  CE2 . TYR A 1 42  ? -10.904 -13.798 3.778   0.50 69.87  ? 305  TYR A CE2 1 
ATOM   293  C  CZ  . TYR A 1 42  ? -11.612 -14.946 4.082   0.50 70.14  ? 305  TYR A CZ  1 
ATOM   294  O  OH  . TYR A 1 42  ? -12.258 -15.054 5.278   0.50 71.85  ? 305  TYR A OH  1 
ATOM   295  N  N   . HIS A 1 43  ? -12.496 -13.146 -0.098  0.50 72.16  ? 306  HIS A N   1 
ATOM   296  C  CA  . HIS A 1 43  ? -13.410 -12.003 0.144   0.50 71.90  ? 306  HIS A CA  1 
ATOM   297  C  C   . HIS A 1 43  ? -13.973 -12.073 1.565   0.50 72.45  ? 306  HIS A C   1 
ATOM   298  O  O   . HIS A 1 43  ? -14.224 -11.005 2.148   0.50 79.86  ? 306  HIS A O   1 
ATOM   299  C  CB  . HIS A 1 43  ? -14.511 -11.986 -0.921  0.50 68.90  ? 306  HIS A CB  1 
ATOM   300  C  CG  . HIS A 1 43  ? -14.007 -11.716 -2.296  0.50 65.70  ? 306  HIS A CG  1 
ATOM   301  N  ND1 . HIS A 1 43  ? -13.700 -10.443 -2.728  0.50 64.64  ? 306  HIS A ND1 1 
ATOM   302  C  CD2 . HIS A 1 43  ? -13.760 -12.540 -3.335  0.50 63.74  ? 306  HIS A CD2 1 
ATOM   303  C  CE1 . HIS A 1 43  ? -13.283 -10.494 -3.975  0.50 63.11  ? 306  HIS A CE1 1 
ATOM   304  N  NE2 . HIS A 1 43  ? -13.312 -11.768 -4.369  0.50 62.08  ? 306  HIS A NE2 1 
ATOM   305  N  N   . GLY A 1 44  ? -14.181 -13.282 2.085   1.00 71.82  ? 307  GLY A N   1 
ATOM   306  C  CA  . GLY A 1 44  ? -14.753 -13.422 3.433   1.00 71.83  ? 307  GLY A CA  1 
ATOM   307  C  C   . GLY A 1 44  ? -15.140 -14.843 3.787   1.00 75.73  ? 307  GLY A C   1 
ATOM   308  O  O   . GLY A 1 44  ? -15.007 -15.717 2.925   1.00 74.18  ? 307  GLY A O   1 
ATOM   309  N  N   . SER A 1 45  ? -15.621 -15.050 5.015   0.50 75.66  ? 308  SER A N   1 
ATOM   310  C  CA  . SER A 1 45  ? -16.009 -16.405 5.483   0.50 77.50  ? 308  SER A CA  1 
ATOM   311  C  C   . SER A 1 45  ? -17.328 -16.331 6.254   0.50 78.63  ? 308  SER A C   1 
ATOM   312  O  O   . SER A 1 45  ? -17.793 -15.204 6.489   0.50 82.71  ? 308  SER A O   1 
ATOM   313  C  CB  . SER A 1 45  ? -14.919 -17.002 6.326   0.50 78.53  ? 308  SER A CB  1 
ATOM   314  O  OG  . SER A 1 45  ? -13.695 -17.044 5.609   0.50 76.44  ? 308  SER A OG  1 
ATOM   315  N  N   . TYR A 1 46  ? -17.899 -17.482 6.628   0.50 79.86  ? 309  TYR A N   1 
ATOM   316  C  CA  . TYR A 1 46  ? -19.179 -17.535 7.387   0.50 81.32  ? 309  TYR A CA  1 
ATOM   317  C  C   . TYR A 1 46  ? -19.473 -18.977 7.830   0.50 83.60  ? 309  TYR A C   1 
ATOM   318  O  O   . TYR A 1 46  ? -19.172 -19.924 7.076   0.50 85.10  ? 309  TYR A O   1 
ATOM   319  C  CB  . TYR A 1 46  ? -20.314 -16.923 6.555   0.50 80.23  ? 309  TYR A CB  1 
ATOM   320  C  CG  . TYR A 1 46  ? -20.855 -17.777 5.433   0.50 78.35  ? 309  TYR A CG  1 
ATOM   321  C  CD1 . TYR A 1 46  ? -21.725 -18.825 5.690   0.50 76.89  ? 309  TYR A CD1 1 
ATOM   322  C  CD2 . TYR A 1 46  ? -20.539 -17.513 4.109   0.50 76.62  ? 309  TYR A CD2 1 
ATOM   323  C  CE1 . TYR A 1 46  ? -22.242 -19.603 4.668   0.50 77.79  ? 309  TYR A CE1 1 
ATOM   324  C  CE2 . TYR A 1 46  ? -21.049 -18.280 3.074   0.50 74.66  ? 309  TYR A CE2 1 
ATOM   325  C  CZ  . TYR A 1 46  ? -21.905 -19.331 3.354   0.50 76.09  ? 309  TYR A CZ  1 
ATOM   326  O  OH  . TYR A 1 46  ? -22.418 -20.099 2.349   0.50 73.78  ? 309  TYR A OH  1 
ATOM   327  N  N   . GLU A 1 47  ? -20.041 -19.128 9.032   0.50 85.11  ? 310  GLU A N   1 
ATOM   328  C  CA  . GLU A 1 47  ? -20.367 -20.432 9.674   0.50 89.45  ? 310  GLU A CA  1 
ATOM   329  C  C   . GLU A 1 47  ? -21.209 -21.279 8.712   0.50 89.64  ? 310  GLU A C   1 
ATOM   330  O  O   . GLU A 1 47  ? -22.107 -20.712 8.059   0.50 95.31  ? 310  GLU A O   1 
ATOM   331  C  CB  . GLU A 1 47  ? -21.107 -20.199 10.995  0.50 91.99  ? 310  GLU A CB  1 
ATOM   332  C  CG  . GLU A 1 47  ? -21.199 -21.435 11.878  0.50 92.56  ? 310  GLU A CG  1 
ATOM   333  C  CD  . GLU A 1 47  ? -22.523 -22.182 11.826  0.50 92.66  ? 310  GLU A CD  1 
ATOM   334  O  OE1 . GLU A 1 47  ? -22.493 -23.421 11.689  0.50 92.07  ? 310  GLU A OE1 1 
ATOM   335  O  OE2 . GLU A 1 47  ? -23.582 -21.526 11.941  0.50 91.91  ? 310  GLU A OE2 1 
ATOM   336  N  N   . THR A 1 48  ? -20.927 -22.585 8.641   0.50 89.26  ? 311  THR A N   1 
ATOM   337  C  CA  . THR A 1 48  ? -21.634 -23.568 7.774   0.50 88.32  ? 311  THR A CA  1 
ATOM   338  C  C   . THR A 1 48  ? -21.438 -24.977 8.341   0.50 87.37  ? 311  THR A C   1 
ATOM   339  O  O   . THR A 1 48  ? -20.673 -25.086 9.319   0.50 91.60  ? 311  THR A O   1 
ATOM   340  C  CB  . THR A 1 48  ? -21.146 -23.474 6.323   0.50 89.03  ? 311  THR A CB  1 
ATOM   341  O  OG1 . THR A 1 48  ? -21.713 -24.565 5.597   0.50 90.32  ? 311  THR A OG1 1 
ATOM   342  C  CG2 . THR A 1 48  ? -19.638 -23.504 6.202   0.50 88.85  ? 311  THR A CG2 1 
ATOM   343  N  N   . ALA A 1 54  ? -19.485 -38.792 1.667   0.34 57.25  ? 317  ALA A N   1 
ATOM   344  C  CA  . ALA A 1 54  ? -19.894 -39.123 0.281   0.34 57.81  ? 317  ALA A CA  1 
ATOM   345  C  C   . ALA A 1 54  ? -18.981 -40.221 -0.279  0.34 56.13  ? 317  ALA A C   1 
ATOM   346  O  O   . ALA A 1 54  ? -18.625 -40.150 -1.474  0.34 56.70  ? 317  ALA A O   1 
ATOM   347  C  CB  . ALA A 1 54  ? -19.862 -37.881 -0.578  0.34 56.75  ? 317  ALA A CB  1 
ATOM   348  N  N   . SER A 1 55  ? -18.632 -41.206 0.556   0.34 54.13  ? 318  SER A N   1 
ATOM   349  C  CA  . SER A 1 55  ? -17.754 -42.355 0.206   0.34 51.73  ? 318  SER A CA  1 
ATOM   350  C  C   . SER A 1 55  ? -18.472 -43.297 -0.771  0.34 48.88  ? 318  SER A C   1 
ATOM   351  O  O   . SER A 1 55  ? -19.685 -43.116 -0.999  0.34 47.34  ? 318  SER A O   1 
ATOM   352  C  CB  . SER A 1 55  ? -17.304 -43.092 1.443   0.34 52.44  ? 318  SER A CB  1 
ATOM   353  O  OG  . SER A 1 55  ? -18.249 -44.084 1.822   0.34 52.22  ? 318  SER A OG  1 
ATOM   354  N  N   . SER A 1 56  ? -17.738 -44.263 -1.328  0.34 45.24  ? 319  SER A N   1 
ATOM   355  C  CA  . SER A 1 56  ? -18.249 -45.291 -2.271  0.34 44.92  ? 319  SER A CA  1 
ATOM   356  C  C   . SER A 1 56  ? -18.857 -46.449 -1.472  0.34 45.53  ? 319  SER A C   1 
ATOM   357  O  O   . SER A 1 56  ? -18.269 -46.811 -0.429  0.34 43.05  ? 319  SER A O   1 
ATOM   358  C  CB  . SER A 1 56  ? -17.149 -45.768 -3.187  0.34 46.15  ? 319  SER A CB  1 
ATOM   359  O  OG  . SER A 1 56  ? -16.454 -46.873 -2.625  0.34 42.17  ? 319  SER A OG  1 
ATOM   360  N  N   . MET A 1 57  ? -20.001 -46.981 -1.921  1.00 45.29  ? 320  MET A N   1 
ATOM   361  C  CA  . MET A 1 57  ? -20.657 -48.153 -1.280  1.00 37.02  ? 320  MET A CA  1 
ATOM   362  C  C   . MET A 1 57  ? -20.444 -49.390 -2.173  1.00 30.38  ? 320  MET A C   1 
ATOM   363  O  O   . MET A 1 57  ? -20.258 -49.206 -3.379  1.00 31.60  ? 320  MET A O   1 
ATOM   364  C  CB  . MET A 1 57  ? -22.127 -47.802 -1.164  1.00 40.15  ? 320  MET A CB  1 
ATOM   365  C  CG  . MET A 1 57  ? -22.338 -46.348 -0.658  1.00 43.21  ? 320  MET A CG  1 
ATOM   366  S  SD  . MET A 1 57  ? -21.630 -46.176 0.982   1.00 46.81  ? 320  MET A SD  1 
ATOM   367  C  CE  . MET A 1 57  ? -22.767 -47.228 1.877   1.00 40.31  ? 320  MET A CE  1 
ATOM   368  N  N   . VAL A 1 58  ? -20.402 -50.586 -1.618  1.00 26.04  ? 321  VAL A N   1 
ATOM   369  C  CA  . VAL A 1 58  ? -20.199 -51.799 -2.441  1.00 24.30  ? 321  VAL A CA  1 
ATOM   370  C  C   . VAL A 1 58  ? -21.536 -52.289 -2.998  1.00 27.09  ? 321  VAL A C   1 
ATOM   371  O  O   . VAL A 1 58  ? -22.511 -52.303 -2.235  1.00 26.92  ? 321  VAL A O   1 
ATOM   372  C  CB  . VAL A 1 58  ? -19.425 -52.884 -1.699  1.00 29.10  ? 321  VAL A CB  1 
ATOM   373  C  CG1 . VAL A 1 58  ? -19.354 -54.174 -2.525  1.00 26.81  ? 321  VAL A CG1 1 
ATOM   374  C  CG2 . VAL A 1 58  ? -18.031 -52.348 -1.400  1.00 33.68  ? 321  VAL A CG2 1 
ATOM   375  N  N   . ASN A 1 59  ? -21.541 -52.682 -4.268  1.00 22.43  ? 322  ASN A N   1 
ATOM   376  C  CA  . ASN A 1 59  ? -22.650 -53.410 -4.921  1.00 22.52  ? 322  ASN A CA  1 
ATOM   377  C  C   . ASN A 1 59  ? -22.585 -54.901 -4.575  1.00 22.87  ? 322  ASN A C   1 
ATOM   378  O  O   . ASN A 1 59  ? -21.767 -55.619 -5.151  1.00 22.77  ? 322  ASN A O   1 
ATOM   379  C  CB  . ASN A 1 59  ? -22.699 -53.202 -6.423  1.00 22.73  ? 322  ASN A CB  1 
ATOM   380  C  CG  . ASN A 1 59  ? -23.944 -53.802 -7.075  1.00 21.99  ? 322  ASN A CG  1 
ATOM   381  O  OD1 . ASN A 1 59  ? -24.385 -54.904 -6.748  1.00 23.69  ? 322  ASN A OD1 1 
ATOM   382  N  ND2 . ASN A 1 59  ? -24.522 -53.067 -8.019  1.00 25.37  ? 322  ASN A ND2 1 
ATOM   383  N  N   . GLY A 1 60  ? -23.449 -55.352 -3.672  1.00 22.51  ? 323  GLY A N   1 
ATOM   384  C  CA  . GLY A 1 60  ? -23.440 -56.742 -3.176  1.00 21.83  ? 323  GLY A CA  1 
ATOM   385  C  C   . GLY A 1 60  ? -23.789 -57.788 -4.197  1.00 22.57  ? 323  GLY A C   1 
ATOM   386  O  O   . GLY A 1 60  ? -23.306 -58.934 -4.097  1.00 25.83  ? 323  GLY A O   1 
ATOM   387  N  N   . VAL A 1 61  ? -24.674 -57.472 -5.158  1.00 21.41  ? 324  VAL A N   1 
ATOM   388  C  CA  . VAL A 1 61  ? -25.009 -58.426 -6.221  1.00 21.87  ? 324  VAL A CA  1 
ATOM   389  C  C   . VAL A 1 61  ? -23.768 -58.688 -7.073  1.00 21.69  ? 324  VAL A C   1 
ATOM   390  O  O   . VAL A 1 61  ? -23.467 -59.844 -7.324  1.00 20.88  ? 324  VAL A O   1 
ATOM   391  C  CB  . VAL A 1 61  ? -26.210 -57.900 -7.037  1.00 22.32  ? 324  VAL A CB  1 
ATOM   392  C  CG1 . VAL A 1 61  ? -26.401 -58.674 -8.298  1.00 23.00  ? 324  VAL A CG1 1 
ATOM   393  C  CG2 . VAL A 1 61  ? -27.461 -57.863 -6.166  1.00 25.46  ? 324  VAL A CG2 1 
ATOM   394  N  N   . VAL A 1 62  ? -23.048 -57.647 -7.504  1.00 20.03  ? 325  VAL A N   1 
ATOM   395  C  CA  . VAL A 1 62  ? -21.847 -57.863 -8.347  1.00 19.68  ? 325  VAL A CA  1 
ATOM   396  C  C   . VAL A 1 62  ? -20.762 -58.566 -7.489  1.00 19.36  ? 325  VAL A C   1 
ATOM   397  O  O   . VAL A 1 62  ? -20.132 -59.513 -7.968  1.00 20.12  ? 325  VAL A O   1 
ATOM   398  C  CB  . VAL A 1 62  ? -21.348 -56.561 -8.983  1.00 20.53  ? 325  VAL A CB  1 
ATOM   399  C  CG1 . VAL A 1 62  ? -20.062 -56.796 -9.763  1.00 21.23  ? 325  VAL A CG1 1 
ATOM   400  C  CG2 . VAL A 1 62  ? -22.374 -55.937 -9.898  1.00 21.17  ? 325  VAL A CG2 1 
ATOM   401  N  N   . ARG A 1 63  ? -20.553 -58.164 -6.246  1.00 20.16  ? 326  ARG A N   1 
ATOM   402  C  CA  . ARG A 1 63  ? -19.453 -58.754 -5.442  1.00 19.95  ? 326  ARG A CA  1 
ATOM   403  C  C   . ARG A 1 63  ? -19.741 -60.228 -5.177  1.00 20.95  ? 326  ARG A C   1 
ATOM   404  O  O   . ARG A 1 63  ? -18.825 -61.057 -5.289  1.00 20.43  ? 326  ARG A O   1 
ATOM   405  C  CB  . ARG A 1 63  ? -19.210 -57.985 -4.157  1.00 19.95  ? 326  ARG A CB  1 
ATOM   406  C  CG  . ARG A 1 63  ? -18.198 -58.699 -3.247  1.00 20.07  ? 326  ARG A CG  1 
ATOM   407  C  CD  . ARG A 1 63  ? -17.492 -57.771 -2.283  1.00 19.74  ? 326  ARG A CD  1 
ATOM   408  N  NE  . ARG A 1 63  ? -18.361 -57.256 -1.240  1.00 20.35  ? 326  ARG A NE  1 
ATOM   409  C  CZ  . ARG A 1 63  ? -18.010 -56.429 -0.278  1.00 20.86  ? 326  ARG A CZ  1 
ATOM   410  N  NH1 . ARG A 1 63  ? -16.743 -56.118 -0.104  1.00 21.91  ? 326  ARG A NH1 1 
ATOM   411  N  NH2 . ARG A 1 63  ? -18.905 -55.976 0.581   1.00 23.07  ? 326  ARG A NH2 1 
ATOM   412  N  N   . LEU A 1 64  ? -20.980 -60.614 -4.840  1.00 21.41  ? 327  LEU A N   1 
ATOM   413  C  CA  . LEU A 1 64  ? -21.253 -62.051 -4.603  1.00 22.25  ? 327  LEU A CA  1 
ATOM   414  C  C   . LEU A 1 64  ? -21.006 -62.898 -5.855  1.00 21.44  ? 327  LEU A C   1 
ATOM   415  O  O   . LEU A 1 64  ? -20.711 -64.113 -5.746  1.00 22.94  ? 327  LEU A O   1 
ATOM   416  C  CB  . LEU A 1 64  ? -22.693 -62.268 -4.084  1.00 21.34  ? 327  LEU A CB  1 
ATOM   417  C  CG  . LEU A 1 64  ? -22.927 -61.919 -2.622  1.00 22.97  ? 327  LEU A CG  1 
ATOM   418  C  CD1 . LEU A 1 64  ? -24.430 -62.035 -2.268  1.00 24.97  ? 327  LEU A CD1 1 
ATOM   419  C  CD2 . LEU A 1 64  ? -22.090 -62.724 -1.644  1.00 24.47  ? 327  LEU A CD2 1 
ATOM   420  N  N   . LEU A 1 65  ? -21.104 -62.332 -7.049  1.00 20.99  ? 328  LEU A N   1 
ATOM   421  C  CA  . LEU A 1 65  ? -20.884 -63.106 -8.297  1.00 20.26  ? 328  LEU A CA  1 
ATOM   422  C  C   . LEU A 1 65  ? -19.467 -62.937 -8.865  1.00 19.27  ? 328  LEU A C   1 
ATOM   423  O  O   . LEU A 1 65  ? -19.223 -63.474 -9.944  1.00 21.30  ? 328  LEU A O   1 
ATOM   424  C  CB  . LEU A 1 65  ? -21.985 -62.686 -9.280  1.00 21.27  ? 328  LEU A CB  1 
ATOM   425  C  CG  . LEU A 1 65  ? -23.404 -63.074 -8.791  1.00 21.67  ? 328  LEU A CG  1 
ATOM   426  C  CD1 . LEU A 1 65  ? -24.503 -62.437 -9.661  1.00 21.85  ? 328  LEU A CD1 1 
ATOM   427  C  CD2 . LEU A 1 65  ? -23.543 -64.572 -8.833  1.00 25.51  ? 328  LEU A CD2 1 
ATOM   428  N  N   . THR A 1 66  ? -18.568 -62.276 -8.151  1.00 18.37  ? 329  THR A N   1 
ATOM   429  C  CA  . THR A 1 66  ? -17.149 -62.138 -8.543  1.00 19.92  ? 329  THR A CA  1 
ATOM   430  C  C   . THR A 1 66  ? -16.233 -62.504 -7.352  1.00 19.89  ? 329  THR A C   1 
ATOM   431  O  O   . THR A 1 66  ? -15.217 -61.815 -7.079  1.00 19.46  ? 329  THR A O   1 
ATOM   432  C  CB  . THR A 1 66  ? -16.892 -60.710 -9.067  1.00 20.81  ? 329  THR A CB  1 
ATOM   433  O  OG1 . THR A 1 66  ? -17.307 -59.695 -8.135  1.00 19.50  ? 329  THR A OG1 1 
ATOM   434  C  CG2 . THR A 1 66  ? -17.613 -60.471 -10.381 1.00 21.45  ? 329  THR A CG2 1 
ATOM   435  N  N   . LYS A 1 67  ? -16.493 -63.609 -6.699  1.00 18.27  ? 330  LYS A N   1 
ATOM   436  C  CA  . LYS A 1 67  ? -15.764 -64.042 -5.488  1.00 20.05  ? 330  LYS A CA  1 
ATOM   437  C  C   . LYS A 1 67  ? -14.249 -64.117 -5.702  1.00 19.32  ? 330  LYS A C   1 
ATOM   438  O  O   . LYS A 1 67  ? -13.533 -63.698 -4.787  1.00 20.39  ? 330  LYS A O   1 
ATOM   439  C  CB  . LYS A 1 67  ? -16.333 -65.356 -4.966  1.00 24.07  ? 330  LYS A CB  1 
ATOM   440  C  CG  . LYS A 1 67  ? -15.758 -65.835 -3.636  1.00 25.04  ? 330  LYS A CG  1 
ATOM   441  C  CD  . LYS A 1 67  ? -16.379 -67.166 -3.183  1.00 28.39  ? 330  LYS A CD  1 
ATOM   442  C  CE  . LYS A 1 67  ? -16.272 -67.301 -1.665  1.00 35.34  ? 330  LYS A CE  1 
ATOM   443  N  NZ  . LYS A 1 67  ? -16.411 -68.712 -1.243  1.00 35.04  ? 330  LYS A NZ  1 
ATOM   444  N  N   . PRO A 1 68  ? -13.682 -64.626 -6.795  1.00 18.95  ? 331  PRO A N   1 
ATOM   445  C  CA  . PRO A 1 68  ? -12.214 -64.734 -6.897  1.00 20.49  ? 331  PRO A CA  1 
ATOM   446  C  C   . PRO A 1 68  ? -11.512 -63.387 -6.683  1.00 23.03  ? 331  PRO A C   1 
ATOM   447  O  O   . PRO A 1 68  ? -10.360 -63.394 -6.227  1.00 22.43  ? 331  PRO A O   1 
ATOM   448  C  CB  . PRO A 1 68  ? -11.971 -65.152 -8.345  1.00 21.17  ? 331  PRO A CB  1 
ATOM   449  C  CG  . PRO A 1 68  ? -13.171 -66.023 -8.636  1.00 22.06  ? 331  PRO A CG  1 
ATOM   450  C  CD  . PRO A 1 68  ? -14.325 -65.287 -7.951  1.00 20.91  ? 331  PRO A CD  1 
ATOM   451  N  N   . TRP A 1 69  ? -12.191 -62.272 -7.022  1.00 19.43  ? 332  TRP A N   1 
ATOM   452  C  CA  . TRP A 1 69  ? -11.626 -60.897 -6.953  1.00 20.49  ? 332  TRP A CA  1 
ATOM   453  C  C   . TRP A 1 69  ? -11.677 -60.374 -5.522  1.00 20.60  ? 332  TRP A C   1 
ATOM   454  O  O   . TRP A 1 69  ? -11.108 -59.294 -5.262  1.00 22.46  ? 332  TRP A O   1 
ATOM   455  C  CB  . TRP A 1 69  ? -12.278 -59.970 -8.005  1.00 19.37  ? 332  TRP A CB  1 
ATOM   456  C  CG  . TRP A 1 69  ? -11.918 -60.374 -9.386  1.00 19.48  ? 332  TRP A CG  1 
ATOM   457  C  CD1 . TRP A 1 69  ? -10.819 -59.932 -10.062 1.00 20.22  ? 332  TRP A CD1 1 
ATOM   458  C  CD2 . TRP A 1 69  ? -12.503 -61.417 -10.199 1.00 20.61  ? 332  TRP A CD2 1 
ATOM   459  N  NE1 . TRP A 1 69  ? -10.697 -60.589 -11.253 1.00 21.04  ? 332  TRP A NE1 1 
ATOM   460  C  CE2 . TRP A 1 69  ? -11.721 -61.500 -11.369 1.00 21.49  ? 332  TRP A CE2 1 
ATOM   461  C  CE3 . TRP A 1 69  ? -13.623 -62.245 -10.101 1.00 21.78  ? 332  TRP A CE3 1 
ATOM   462  C  CZ2 . TRP A 1 69  ? -12.023 -62.372 -12.416 1.00 24.22  ? 332  TRP A CZ2 1 
ATOM   463  C  CZ3 . TRP A 1 69  ? -13.920 -63.108 -11.132 1.00 21.16  ? 332  TRP A CZ3 1 
ATOM   464  C  CH2 . TRP A 1 69  ? -13.096 -63.211 -12.259 1.00 22.26  ? 332  TRP A CH2 1 
ATOM   465  N  N   . ASP A 1 70  ? -12.279 -61.115 -4.577  1.00 20.83  ? 333  ASP A N   1 
ATOM   466  C  CA  . ASP A 1 70  ? -12.332 -60.679 -3.152  1.00 19.98  ? 333  ASP A CA  1 
ATOM   467  C  C   . ASP A 1 70  ? -10.927 -60.628 -2.517  1.00 21.48  ? 333  ASP A C   1 
ATOM   468  O  O   . ASP A 1 70  ? -10.793 -60.002 -1.471  1.00 22.25  ? 333  ASP A O   1 
ATOM   469  C  CB  . ASP A 1 70  ? -13.235 -61.585 -2.297  1.00 21.25  ? 333  ASP A CB  1 
ATOM   470  C  CG  . ASP A 1 70  ? -14.711 -61.486 -2.627  1.00 21.73  ? 333  ASP A CG  1 
ATOM   471  O  OD1 . ASP A 1 70  ? -15.078 -60.552 -3.371  1.00 23.38  ? 333  ASP A OD1 1 
ATOM   472  O  OD2 . ASP A 1 70  ? -15.494 -62.311 -2.060  1.00 20.76  ? 333  ASP A OD2 1 
ATOM   473  N  N   . ILE A 1 71  ? -9.939  -61.273 -3.126  1.00 21.06  ? 334  ILE A N   1 
ATOM   474  C  CA  . ILE A 1 71  ? -8.561  -61.378 -2.583  1.00 22.00  ? 334  ILE A CA  1 
ATOM   475  C  C   . ILE A 1 71  ? -7.577  -60.686 -3.530  1.00 26.37  ? 334  ILE A C   1 
ATOM   476  O  O   . ILE A 1 71  ? -6.330  -60.829 -3.329  1.00 26.04  ? 334  ILE A O   1 
ATOM   477  C  CB  . ILE A 1 71  ? -8.187  -62.839 -2.283  1.00 24.96  ? 334  ILE A CB  1 
ATOM   478  C  CG1 . ILE A 1 71  ? -8.210  -63.728 -3.528  1.00 27.26  ? 334  ILE A CG1 1 
ATOM   479  C  CG2 . ILE A 1 71  ? -9.046  -63.386 -1.152  1.00 28.55  ? 334  ILE A CG2 1 
ATOM   480  C  CD1 . ILE A 1 71  ? -7.481  -65.066 -3.378  1.00 31.46  ? 334  ILE A CD1 1 
ATOM   481  N  N   . ILE A 1 72  ? -8.046  -59.907 -4.483  1.00 23.71  ? 335  ILE A N   1 
ATOM   482  C  CA  . ILE A 1 72  ? -7.174  -59.112 -5.397  1.00 23.35  ? 335  ILE A CA  1 
ATOM   483  C  C   . ILE A 1 72  ? -7.212  -57.668 -4.939  1.00 25.93  ? 335  ILE A C   1 
ATOM   484  O  O   . ILE A 1 72  ? -8.174  -56.919 -5.192  1.00 23.93  ? 335  ILE A O   1 
ATOM   485  C  CB  . ILE A 1 72  ? -7.655  -59.331 -6.847  1.00 26.91  ? 335  ILE A CB  1 
ATOM   486  C  CG1 . ILE A 1 72  ? -7.601  -60.833 -7.169  1.00 31.21  ? 335  ILE A CG1 1 
ATOM   487  C  CG2 . ILE A 1 72  ? -6.922  -58.394 -7.832  1.00 25.44  ? 335  ILE A CG2 1 
ATOM   488  C  CD1 . ILE A 1 72  ? -6.932  -61.265 -8.416  1.00 36.82  ? 335  ILE A CD1 1 
ATOM   489  N  N   . PRO A 1 73  ? -6.114  -57.164 -4.322  1.00 27.11  ? 336  PRO A N   1 
ATOM   490  C  CA  . PRO A 1 73  ? -6.094  -55.794 -3.803  1.00 27.06  ? 336  PRO A CA  1 
ATOM   491  C  C   . PRO A 1 73  ? -6.359  -54.696 -4.839  1.00 25.78  ? 336  PRO A C   1 
ATOM   492  O  O   . PRO A 1 73  ? -7.018  -53.727 -4.498  1.00 25.52  ? 336  PRO A O   1 
ATOM   493  C  CB  . PRO A 1 73  ? -4.653  -55.651 -3.252  1.00 32.23  ? 336  PRO A CB  1 
ATOM   494  C  CG  . PRO A 1 73  ? -4.289  -57.066 -2.900  1.00 33.09  ? 336  PRO A CG  1 
ATOM   495  C  CD  . PRO A 1 73  ? -4.893  -57.923 -4.007  1.00 28.44  ? 336  PRO A CD  1 
ATOM   496  N  N   . MET A 1 74  ? -5.954  -54.874 -6.091  1.00 25.54  ? 337  MET A N   1 
ATOM   497  C  CA  . MET A 1 74  ? -6.260  -53.829 -7.112  1.00 29.41  ? 337  MET A CA  1 
ATOM   498  C  C   . MET A 1 74  ? -7.781  -53.664 -7.287  1.00 32.49  ? 337  MET A C   1 
ATOM   499  O  O   . MET A 1 74  ? -8.209  -52.568 -7.633  1.00 30.85  ? 337  MET A O   1 
ATOM   500  C  CB  . MET A 1 74  ? -5.636  -54.164 -8.460  1.00 33.00  ? 337  MET A CB  1 
ATOM   501  C  CG  . MET A 1 74  ? -4.108  -54.131 -8.405  1.00 42.03  ? 337  MET A CG  1 
ATOM   502  S  SD  . MET A 1 74  ? -3.518  -52.381 -8.134  1.00 49.36  ? 337  MET A SD  1 
ATOM   503  C  CE  . MET A 1 74  ? -4.514  -51.504 -9.338  1.00 49.42  ? 337  MET A CE  1 
ATOM   504  N  N   . VAL A 1 75  ? -8.574  -54.704 -7.042  1.00 23.99  ? 338  VAL A N   1 
ATOM   505  C  CA  . VAL A 1 75  ? -10.065 -54.591 -7.057  1.00 22.72  ? 338  VAL A CA  1 
ATOM   506  C  C   . VAL A 1 75  ? -10.561 -54.067 -5.714  1.00 24.65  ? 338  VAL A C   1 
ATOM   507  O  O   . VAL A 1 75  ? -11.337 -53.148 -5.727  1.00 27.61  ? 338  VAL A O   1 
ATOM   508  C  CB  . VAL A 1 75  ? -10.718 -55.959 -7.349  1.00 22.56  ? 338  VAL A CB  1 
ATOM   509  C  CG1 . VAL A 1 75  ? -12.222 -55.932 -7.078  1.00 24.08  ? 338  VAL A CG1 1 
ATOM   510  C  CG2 . VAL A 1 75  ? -10.418 -56.405 -8.760  1.00 22.88  ? 338  VAL A CG2 1 
ATOM   511  N  N   . THR A 1 76  ? -10.163 -54.684 -4.610  1.00 23.38  ? 339  THR A N   1 
ATOM   512  C  CA  . THR A 1 76  ? -10.753 -54.456 -3.275  1.00 24.04  ? 339  THR A CA  1 
ATOM   513  C  C   . THR A 1 76  ? -10.437 -53.054 -2.778  1.00 25.56  ? 339  THR A C   1 
ATOM   514  O  O   . THR A 1 76  ? -11.296 -52.452 -2.184  1.00 24.89  ? 339  THR A O   1 
ATOM   515  C  CB  . THR A 1 76  ? -10.365 -55.523 -2.243  1.00 25.69  ? 339  THR A CB  1 
ATOM   516  O  OG1 . THR A 1 76  ? -8.959  -55.445 -2.029  1.00 26.76  ? 339  THR A OG1 1 
ATOM   517  C  CG2 . THR A 1 76  ? -10.775 -56.923 -2.671  1.00 25.89  ? 339  THR A CG2 1 
ATOM   518  N  N   . GLN A 1 77  ? -9.257  -52.522 -3.107  0.34 25.82  ? 340  GLN A N   1 
ATOM   519  C  CA  . GLN A 1 77  ? -8.802  -51.205 -2.591  0.34 26.64  ? 340  GLN A CA  1 
ATOM   520  C  C   . GLN A 1 77  ? -9.484  -50.066 -3.371  0.34 26.94  ? 340  GLN A C   1 
ATOM   521  O  O   . GLN A 1 77  ? -9.436  -48.933 -2.865  0.34 27.49  ? 340  GLN A O   1 
ATOM   522  C  CB  . GLN A 1 77  ? -7.269  -51.181 -2.546  0.34 25.74  ? 340  GLN A CB  1 
ATOM   523  C  CG  . GLN A 1 77  ? -6.701  -52.184 -1.536  0.34 26.96  ? 340  GLN A CG  1 
ATOM   524  C  CD  . GLN A 1 77  ? -5.194  -52.133 -1.401  0.34 28.83  ? 340  GLN A CD  1 
ATOM   525  O  OE1 . GLN A 1 77  ? -4.552  -51.182 -1.835  0.34 30.65  ? 340  GLN A OE1 1 
ATOM   526  N  NE2 . GLN A 1 77  ? -4.615  -53.157 -0.789  0.34 28.13  ? 340  GLN A NE2 1 
ATOM   527  N  N   . MET A 1 78  ? -10.138 -50.347 -4.510  1.00 27.13  ? 341  MET A N   1 
ATOM   528  C  CA  . MET A 1 78  ? -10.907 -49.325 -5.273  1.00 29.11  ? 341  MET A CA  1 
ATOM   529  C  C   . MET A 1 78  ? -12.132 -48.863 -4.490  1.00 27.68  ? 341  MET A C   1 
ATOM   530  O  O   . MET A 1 78  ? -12.557 -47.729 -4.681  1.00 26.05  ? 341  MET A O   1 
ATOM   531  C  CB  . MET A 1 78  ? -11.378 -49.794 -6.649  1.00 30.52  ? 341  MET A CB  1 
ATOM   532  C  CG  . MET A 1 78  ? -10.250 -50.071 -7.637  1.00 39.93  ? 341  MET A CG  1 
ATOM   533  S  SD  . MET A 1 78  ? -10.870 -50.390 -9.356  1.00 40.07  ? 341  MET A SD  1 
ATOM   534  C  CE  . MET A 1 78  ? -12.163 -49.167 -9.337  1.00 28.97  ? 341  MET A CE  1 
ATOM   535  N  N   . ALA A 1 79  ? -12.699 -49.708 -3.630  1.00 26.72  ? 342  ALA A N   1 
ATOM   536  C  CA  . ALA A 1 79  ? -13.931 -49.376 -2.880  1.00 30.04  ? 342  ALA A CA  1 
ATOM   537  C  C   . ALA A 1 79  ? -13.623 -48.639 -1.566  1.00 32.02  ? 342  ALA A C   1 
ATOM   538  O  O   . ALA A 1 79  ? -14.560 -48.153 -0.951  1.00 32.00  ? 342  ALA A O   1 
ATOM   539  C  CB  . ALA A 1 79  ? -14.706 -50.669 -2.646  1.00 33.66  ? 342  ALA A CB  1 
ATOM   540  N  N   . MET A 1 80  ? -12.358 -48.592 -1.136  0.34 32.38  ? 343  MET A N   1 
ATOM   541  C  CA  . MET A 1 80  ? -11.973 -48.063 0.203   0.34 33.83  ? 343  MET A CA  1 
ATOM   542  C  C   . MET A 1 80  ? -11.728 -46.547 0.127   0.34 38.89  ? 343  MET A C   1 
ATOM   543  O  O   . MET A 1 80  ? -11.110 -46.072 -0.869  0.34 35.92  ? 343  MET A O   1 
ATOM   544  C  CB  . MET A 1 80  ? -10.720 -48.760 0.750   0.34 31.89  ? 343  MET A CB  1 
ATOM   545  C  CG  . MET A 1 80  ? -10.696 -50.278 0.544   0.34 30.30  ? 343  MET A CG  1 
ATOM   546  S  SD  . MET A 1 80  ? -12.079 -51.218 1.288   0.34 29.00  ? 343  MET A SD  1 
ATOM   547  C  CE  . MET A 1 80  ? -11.602 -51.312 3.012   0.34 26.54  ? 343  MET A CE  1 
ATOM   548  N  N   . THR A 1 81  ? -12.194 -45.819 1.151   0.50 43.82  ? 344  THR A N   1 
ATOM   549  C  CA  . THR A 1 81  ? -11.921 -44.380 1.351   0.50 47.34  ? 344  THR A CA  1 
ATOM   550  C  C   . THR A 1 81  ? -13.030 -43.698 2.129   0.50 47.87  ? 344  THR A C   1 
ATOM   551  O  O   . THR A 1 81  ? -14.170 -43.723 1.626   0.50 51.22  ? 344  THR A O   1 
ATOM   552  N  N   . LYS A 1 93  ? -7.549  -27.830 -3.428  0.50 108.63 ? 356  LYS A N   1 
ATOM   553  C  CA  . LYS A 1 93  ? -7.004  -29.167 -3.794  0.50 108.03 ? 356  LYS A CA  1 
ATOM   554  C  C   . LYS A 1 93  ? -5.476  -29.078 -3.922  0.50 107.69 ? 356  LYS A C   1 
ATOM   555  O  O   . LYS A 1 93  ? -4.830  -30.143 -3.994  0.50 109.37 ? 356  LYS A O   1 
ATOM   556  C  CB  . LYS A 1 93  ? -7.660  -29.671 -5.086  0.50 107.45 ? 356  LYS A CB  1 
ATOM   557  C  CG  . LYS A 1 93  ? -7.036  -30.917 -5.705  0.50 106.95 ? 356  LYS A CG  1 
ATOM   558  C  CD  . LYS A 1 93  ? -7.073  -32.148 -4.816  0.50 105.42 ? 356  LYS A CD  1 
ATOM   559  C  CE  . LYS A 1 93  ? -6.373  -33.344 -5.430  0.50 102.52 ? 356  LYS A CE  1 
ATOM   560  N  NZ  . LYS A 1 93  ? -6.265  -34.474 -4.477  0.50 100.21 ? 356  LYS A NZ  1 
ATOM   561  N  N   . GLU A 1 94  ? -4.926  -27.857 -3.936  0.50 106.28 ? 357  GLU A N   1 
ATOM   562  C  CA  . GLU A 1 94  ? -3.462  -27.579 -4.002  0.50 104.40 ? 357  GLU A CA  1 
ATOM   563  C  C   . GLU A 1 94  ? -3.000  -27.565 -5.465  0.50 103.12 ? 357  GLU A C   1 
ATOM   564  O  O   . GLU A 1 94  ? -1.818  -27.245 -5.708  0.50 100.56 ? 357  GLU A O   1 
ATOM   565  C  CB  . GLU A 1 94  ? -2.677  -28.622 -3.203  0.50 103.89 ? 357  GLU A CB  1 
ATOM   566  C  CG  . GLU A 1 94  ? -2.803  -28.463 -1.697  0.50 104.86 ? 357  GLU A CG  1 
ATOM   567  C  CD  . GLU A 1 94  ? -4.068  -29.043 -1.085  0.50 104.57 ? 357  GLU A CD  1 
ATOM   568  O  OE1 . GLU A 1 94  ? -4.472  -28.568 -0.005  0.50 99.57  ? 357  GLU A OE1 1 
ATOM   569  O  OE2 . GLU A 1 94  ? -4.642  -29.976 -1.683  0.50 108.18 ? 357  GLU A OE2 1 
ATOM   570  N  N   . LYS A 1 95  ? -3.898  -27.910 -6.394  0.50 101.57 ? 358  LYS A N   1 
ATOM   571  C  CA  . LYS A 1 95  ? -3.654  -27.901 -7.862  0.50 94.88  ? 358  LYS A CA  1 
ATOM   572  C  C   . LYS A 1 95  ? -4.422  -26.730 -8.483  0.50 87.79  ? 358  LYS A C   1 
ATOM   573  O  O   . LYS A 1 95  ? -3.982  -26.217 -9.531  0.50 82.26  ? 358  LYS A O   1 
ATOM   574  C  CB  . LYS A 1 95  ? -4.092  -29.230 -8.486  0.50 96.49  ? 358  LYS A CB  1 
ATOM   575  C  CG  . LYS A 1 95  ? -3.910  -29.329 -9.995  0.50 95.82  ? 358  LYS A CG  1 
ATOM   576  C  CD  . LYS A 1 95  ? -2.493  -29.060 -10.448 0.50 94.92  ? 358  LYS A CD  1 
ATOM   577  C  CE  . LYS A 1 95  ? -2.330  -29.137 -11.950 0.50 94.22  ? 358  LYS A CE  1 
ATOM   578  N  NZ  . LYS A 1 95  ? -0.912  -28.992 -12.353 0.50 93.70  ? 358  LYS A NZ  1 
ATOM   579  N  N   . VAL A 1 96  ? -5.525  -26.331 -7.841  0.50 83.66  ? 359  VAL A N   1 
ATOM   580  C  CA  . VAL A 1 96  ? -6.428  -25.232 -8.295  0.50 80.78  ? 359  VAL A CA  1 
ATOM   581  C  C   . VAL A 1 96  ? -5.846  -23.888 -7.835  0.50 78.75  ? 359  VAL A C   1 
ATOM   582  O  O   . VAL A 1 96  ? -6.107  -22.872 -8.512  0.50 76.98  ? 359  VAL A O   1 
ATOM   583  C  CB  . VAL A 1 96  ? -7.864  -25.445 -7.774  0.50 78.35  ? 359  VAL A CB  1 
ATOM   584  C  CG1 . VAL A 1 96  ? -7.981  -25.144 -6.287  0.50 77.87  ? 359  VAL A CG1 1 
ATOM   585  C  CG2 . VAL A 1 96  ? -8.877  -24.639 -8.571  0.50 76.58  ? 359  VAL A CG2 1 
ATOM   586  N  N   . ASP A 1 97  ? -5.076  -23.885 -6.741  0.50 75.56  ? 360  ASP A N   1 
ATOM   587  C  CA  . ASP A 1 97  ? -4.464  -22.659 -6.161  0.50 75.58  ? 360  ASP A CA  1 
ATOM   588  C  C   . ASP A 1 97  ? -3.108  -22.402 -6.833  0.50 78.69  ? 360  ASP A C   1 
ATOM   589  O  O   . ASP A 1 97  ? -2.272  -21.698 -6.225  0.50 80.98  ? 360  ASP A O   1 
ATOM   590  C  CB  . ASP A 1 97  ? -4.340  -22.757 -4.637  0.50 72.56  ? 360  ASP A CB  1 
ATOM   591  C  CG  . ASP A 1 97  ? -4.332  -21.406 -3.939  0.50 70.51  ? 360  ASP A CG  1 
ATOM   592  O  OD1 . ASP A 1 97  ? -4.420  -20.379 -4.642  0.50 71.17  ? 360  ASP A OD1 1 
ATOM   593  O  OD2 . ASP A 1 97  ? -4.239  -21.388 -2.699  0.50 70.69  ? 360  ASP A OD2 1 
ATOM   594  N  N   . THR A 1 98  ? -2.902  -22.944 -8.039  0.50 78.84  ? 361  THR A N   1 
ATOM   595  C  CA  . THR A 1 98  ? -1.742  -22.636 -8.920  0.50 80.77  ? 361  THR A CA  1 
ATOM   596  C  C   . THR A 1 98  ? -2.142  -21.498 -9.865  0.50 82.46  ? 361  THR A C   1 
ATOM   597  O  O   . THR A 1 98  ? -3.353  -21.234 -9.984  0.50 80.63  ? 361  THR A O   1 
ATOM   598  C  CB  . THR A 1 98  ? -1.258  -23.872 -9.691  0.50 79.70  ? 361  THR A CB  1 
ATOM   599  O  OG1 . THR A 1 98  ? -2.336  -24.374 -10.482 0.50 79.06  ? 361  THR A OG1 1 
ATOM   600  C  CG2 . THR A 1 98  ? -0.741  -24.966 -8.782  0.50 80.12  ? 361  THR A CG2 1 
ATOM   601  N  N   . ARG A 1 99  ? -1.159  -20.844 -10.490 0.50 88.24  ? 362  ARG A N   1 
ATOM   602  C  CA  . ARG A 1 99  ? -1.375  -19.735 -11.457 0.50 94.58  ? 362  ARG A CA  1 
ATOM   603  C  C   . ARG A 1 99  ? -0.771  -20.137 -12.808 0.50 97.55  ? 362  ARG A C   1 
ATOM   604  O  O   . ARG A 1 99  ? 0.171   -20.955 -12.811 0.50 98.64  ? 362  ARG A O   1 
ATOM   605  C  CB  . ARG A 1 99  ? -0.751  -18.435 -10.939 0.50 97.80  ? 362  ARG A CB  1 
ATOM   606  C  CG  . ARG A 1 99  ? -1.545  -17.184 -11.290 0.50 101.75 ? 362  ARG A CG  1 
ATOM   607  C  CD  . ARG A 1 99  ? -0.685  -15.934 -11.301 0.50 105.10 ? 362  ARG A CD  1 
ATOM   608  N  NE  . ARG A 1 99  ? 0.341   -15.988 -12.334 0.50 107.78 ? 362  ARG A NE  1 
ATOM   609  C  CZ  . ARG A 1 99  ? 1.022   -14.937 -12.777 0.50 105.89 ? 362  ARG A CZ  1 
ATOM   610  N  NH1 . ARG A 1 99  ? 0.785   -13.737 -12.277 0.50 106.39 ? 362  ARG A NH1 1 
ATOM   611  N  NH2 . ARG A 1 99  ? 1.934   -15.089 -13.720 0.50 104.47 ? 362  ARG A NH2 1 
ATOM   612  N  N   . THR A 1 100 ? -1.306  -19.585 -13.902 1.00 99.45  ? 363  THR A N   1 
ATOM   613  C  CA  . THR A 1 100 ? -0.832  -19.856 -15.286 1.00 93.47  ? 363  THR A CA  1 
ATOM   614  C  C   . THR A 1 100 ? -0.367  -18.534 -15.896 1.00 84.97  ? 363  THR A C   1 
ATOM   615  O  O   . THR A 1 100 ? -1.188  -17.607 -15.969 1.00 95.60  ? 363  THR A O   1 
ATOM   616  C  CB  . THR A 1 100 ? -1.921  -20.545 -16.117 1.00 95.63  ? 363  THR A CB  1 
ATOM   617  O  OG1 . THR A 1 100 ? -2.485  -21.624 -15.372 1.00 89.15  ? 363  THR A OG1 1 
ATOM   618  C  CG2 . THR A 1 100 ? -1.384  -21.086 -17.422 1.00 98.45  ? 363  THR A CG2 1 
ATOM   619  N  N   . GLN A 1 101 ? 0.907   -18.458 -16.290 1.00 80.25  ? 364  GLN A N   1 
ATOM   620  C  CA  . GLN A 1 101 ? 1.552   -17.234 -16.838 1.00 81.92  ? 364  GLN A CA  1 
ATOM   621  C  C   . GLN A 1 101 ? 0.887   -16.852 -18.168 1.00 78.09  ? 364  GLN A C   1 
ATOM   622  O  O   . GLN A 1 101 ? 0.305   -17.724 -18.817 1.00 84.59  ? 364  GLN A O   1 
ATOM   623  C  CB  . GLN A 1 101 ? 3.063   -17.450 -16.989 1.00 79.63  ? 364  GLN A CB  1 
ATOM   624  C  CG  . GLN A 1 101 ? 3.753   -16.338 -17.772 1.00 89.47  ? 364  GLN A CG  1 
ATOM   625  C  CD  . GLN A 1 101 ? 5.237   -16.230 -17.516 1.00 96.73  ? 364  GLN A CD  1 
ATOM   626  O  OE1 . GLN A 1 101 ? 5.932   -17.233 -17.351 1.00 101.44 ? 364  GLN A OE1 1 
ATOM   627  N  NE2 . GLN A 1 101 ? 5.733   -15.000 -17.493 1.00 92.93  ? 364  GLN A NE2 1 
ATOM   628  N  N   . GLU A 1 102 ? 0.969   -15.579 -18.551 1.00 76.59  ? 365  GLU A N   1 
ATOM   629  C  CA  . GLU A 1 102 ? 0.461   -15.062 -19.848 1.00 72.12  ? 365  GLU A CA  1 
ATOM   630  C  C   . GLU A 1 102 ? 1.321   -15.621 -20.980 1.00 65.00  ? 365  GLU A C   1 
ATOM   631  O  O   . GLU A 1 102 ? 2.547   -15.539 -20.951 1.00 55.95  ? 365  GLU A O   1 
ATOM   632  C  CB  . GLU A 1 102 ? 0.454   -13.529 -19.825 1.00 80.02  ? 365  GLU A CB  1 
ATOM   633  C  CG  . GLU A 1 102 ? -0.108  -12.872 -21.082 1.00 89.69  ? 365  GLU A CG  1 
ATOM   634  C  CD  . GLU A 1 102 ? -1.578  -12.475 -21.047 1.00 97.38  ? 365  GLU A CD  1 
ATOM   635  O  OE1 . GLU A 1 102 ? -1.905  -11.377 -21.553 1.00 105.85 ? 365  GLU A OE1 1 
ATOM   636  O  OE2 . GLU A 1 102 ? -2.398  -13.268 -20.541 1.00 94.43  ? 365  GLU A OE2 1 
ATOM   637  N  N   . PRO A 1 103 ? 0.716   -16.194 -22.044 1.00 58.53  ? 366  PRO A N   1 
ATOM   638  C  CA  . PRO A 1 103 ? 1.480   -16.578 -23.225 1.00 57.04  ? 366  PRO A CA  1 
ATOM   639  C  C   . PRO A 1 103 ? 2.115   -15.343 -23.882 1.00 57.32  ? 366  PRO A C   1 
ATOM   640  O  O   . PRO A 1 103 ? 1.638   -14.259 -23.637 1.00 54.28  ? 366  PRO A O   1 
ATOM   641  C  CB  . PRO A 1 103 ? 0.427   -17.215 -24.152 1.00 59.16  ? 366  PRO A CB  1 
ATOM   642  C  CG  . PRO A 1 103 ? -0.708  -17.600 -23.226 1.00 57.22  ? 366  PRO A CG  1 
ATOM   643  C  CD  . PRO A 1 103 ? -0.719  -16.500 -22.187 1.00 61.19  ? 366  PRO A CD  1 
ATOM   644  N  N   . LYS A 1 104 ? 3.131   -15.563 -24.714 1.00 55.49  ? 367  LYS A N   1 
ATOM   645  C  CA  . LYS A 1 104 ? 3.834   -14.541 -25.535 1.00 59.26  ? 367  LYS A CA  1 
ATOM   646  C  C   . LYS A 1 104 ? 2.929   -14.071 -26.681 1.00 58.76  ? 367  LYS A C   1 
ATOM   647  O  O   . LYS A 1 104 ? 1.943   -14.745 -27.011 1.00 53.48  ? 367  LYS A O   1 
ATOM   648  C  CB  . LYS A 1 104 ? 5.101   -15.122 -26.183 1.00 67.10  ? 367  LYS A CB  1 
ATOM   649  C  CG  . LYS A 1 104 ? 6.092   -15.840 -25.269 1.00 70.97  ? 367  LYS A CG  1 
ATOM   650  C  CD  . LYS A 1 104 ? 6.262   -15.178 -23.944 1.00 74.00  ? 367  LYS A CD  1 
ATOM   651  C  CE  . LYS A 1 104 ? 7.555   -15.555 -23.262 1.00 77.41  ? 367  LYS A CE  1 
ATOM   652  N  NZ  . LYS A 1 104 ? 7.475   -15.251 -21.816 1.00 80.30  ? 367  LYS A NZ  1 
ATOM   653  N  N   . GLU A 1 105 ? 3.342   -13.017 -27.365 1.00 49.84  ? 368  GLU A N   1 
ATOM   654  C  CA  . GLU A 1 105 ? 2.549   -12.328 -28.410 1.00 57.09  ? 368  GLU A CA  1 
ATOM   655  C  C   . GLU A 1 105 ? 2.359   -13.239 -29.630 1.00 51.43  ? 368  GLU A C   1 
ATOM   656  O  O   . GLU A 1 105 ? 1.218   -13.286 -30.154 1.00 55.39  ? 368  GLU A O   1 
ATOM   657  C  CB  . GLU A 1 105 ? 3.241   -11.001 -28.760 1.00 64.39  ? 368  GLU A CB  1 
ATOM   658  C  CG  . GLU A 1 105 ? 3.278   -10.029 -27.579 1.00 70.36  ? 368  GLU A CG  1 
ATOM   659  C  CD  . GLU A 1 105 ? 1.911   -9.698  -26.997 1.00 67.19  ? 368  GLU A CD  1 
ATOM   660  O  OE1 . GLU A 1 105 ? 1.013   -9.354  -27.791 1.00 75.18  ? 368  GLU A OE1 1 
ATOM   661  O  OE2 . GLU A 1 105 ? 1.731   -9.821  -25.766 1.00 65.97  ? 368  GLU A OE2 1 
ATOM   662  N  N   . GLY A 1 106 ? 3.426   -13.899 -30.097 1.00 46.63  ? 369  GLY A N   1 
ATOM   663  C  CA  . GLY A 1 106 ? 3.332   -14.875 -31.197 1.00 47.68  ? 369  GLY A CA  1 
ATOM   664  C  C   . GLY A 1 106 ? 2.340   -15.990 -30.834 1.00 42.38  ? 369  GLY A C   1 
ATOM   665  O  O   . GLY A 1 106 ? 1.506   -16.308 -31.705 1.00 43.91  ? 369  GLY A O   1 
ATOM   666  N  N   . THR A 1 107 ? 2.354   -16.481 -29.591 1.00 41.52  ? 370  THR A N   1 
ATOM   667  C  CA  . THR A 1 107 ? 1.435   -17.574 -29.119 1.00 45.25  ? 370  THR A CA  1 
ATOM   668  C  C   . THR A 1 107 ? -0.020  -17.099 -29.168 1.00 49.25  ? 370  THR A C   1 
ATOM   669  O  O   . THR A 1 107 ? -0.865  -17.791 -29.771 1.00 46.22  ? 370  THR A O   1 
ATOM   670  C  CB  . THR A 1 107 ? 1.790   -18.083 -27.722 1.00 44.23  ? 370  THR A CB  1 
ATOM   671  O  OG1 . THR A 1 107 ? 3.190   -18.338 -27.746 1.00 47.46  ? 370  THR A OG1 1 
ATOM   672  C  CG2 . THR A 1 107 ? 1.071   -19.367 -27.341 1.00 44.05  ? 370  THR A CG2 1 
ATOM   673  N  N   . LYS A 1 108 ? -0.301  -15.940 -28.563 0.50 49.72  ? 371  LYS A N   1 
ATOM   674  C  CA  . LYS A 1 108 ? -1.654  -15.322 -28.504 0.50 49.88  ? 371  LYS A CA  1 
ATOM   675  C  C   . LYS A 1 108 ? -2.182  -15.075 -29.925 0.50 49.44  ? 371  LYS A C   1 
ATOM   676  O  O   . LYS A 1 108 ? -3.393  -15.270 -30.137 0.50 48.60  ? 371  LYS A O   1 
ATOM   677  C  CB  . LYS A 1 108 ? -1.600  -14.047 -27.657 0.50 55.17  ? 371  LYS A CB  1 
ATOM   678  C  CG  . LYS A 1 108 ? -1.148  -14.267 -26.219 0.50 58.00  ? 371  LYS A CG  1 
ATOM   679  C  CD  . LYS A 1 108 ? -1.519  -13.149 -25.271 0.50 62.28  ? 371  LYS A CD  1 
ATOM   680  C  CE  . LYS A 1 108 ? -0.682  -11.903 -25.459 0.50 65.94  ? 371  LYS A CE  1 
ATOM   681  N  NZ  . LYS A 1 108 ? -0.808  -10.989 -24.300 0.50 69.34  ? 371  LYS A NZ  1 
ATOM   682  N  N   . LYS A 1 109 ? -1.313  -14.703 -30.871 0.50 47.28  ? 372  LYS A N   1 
ATOM   683  C  CA  . LYS A 1 109 ? -1.682  -14.500 -32.298 0.50 48.19  ? 372  LYS A CA  1 
ATOM   684  C  C   . LYS A 1 109 ? -2.049  -15.848 -32.938 0.50 45.73  ? 372  LYS A C   1 
ATOM   685  O  O   . LYS A 1 109 ? -3.098  -15.912 -33.612 0.50 46.69  ? 372  LYS A O   1 
ATOM   686  C  CB  . LYS A 1 109 ? -0.540  -13.819 -33.060 0.50 52.51  ? 372  LYS A CB  1 
ATOM   687  C  CG  . LYS A 1 109 ? -0.869  -13.401 -34.488 0.50 56.96  ? 372  LYS A CG  1 
ATOM   688  C  CD  . LYS A 1 109 ? -1.968  -12.355 -34.584 0.50 62.44  ? 372  LYS A CD  1 
ATOM   689  C  CE  . LYS A 1 109 ? -1.580  -11.022 -33.979 0.50 64.06  ? 372  LYS A CE  1 
ATOM   690  N  NZ  . LYS A 1 109 ? -2.704  -10.056 -34.023 0.50 66.09  ? 372  LYS A NZ  1 
ATOM   691  N  N   . LEU A 1 110 ? -1.208  -16.876 -32.766 0.50 44.10  ? 373  LEU A N   1 
ATOM   692  C  CA  . LEU A 1 110 ? -1.434  -18.242 -33.323 0.50 41.75  ? 373  LEU A CA  1 
ATOM   693  C  C   . LEU A 1 110 ? -2.802  -18.747 -32.847 0.50 36.00  ? 373  LEU A C   1 
ATOM   694  O  O   . LEU A 1 110 ? -3.598  -19.207 -33.687 0.50 38.16  ? 373  LEU A O   1 
ATOM   695  C  CB  . LEU A 1 110 ? -0.307  -19.180 -32.871 0.50 41.22  ? 373  LEU A CB  1 
ATOM   696  C  CG  . LEU A 1 110 ? 1.042   -18.974 -33.562 0.50 39.61  ? 373  LEU A CG  1 
ATOM   697  C  CD1 . LEU A 1 110 ? 2.165   -19.638 -32.778 0.50 39.18  ? 373  LEU A CD1 1 
ATOM   698  C  CD2 . LEU A 1 110 ? 1.009   -19.495 -34.991 0.50 40.41  ? 373  LEU A CD2 1 
ATOM   699  N  N   . MET A 1 111 ? -3.079  -18.611 -31.557 0.50 35.16  ? 374  MET A N   1 
ATOM   700  C  CA  . MET A 1 111 ? -4.340  -19.089 -30.930 0.50 37.27  ? 374  MET A CA  1 
ATOM   701  C  C   . MET A 1 111 ? -5.541  -18.319 -31.504 0.50 38.85  ? 374  MET A C   1 
ATOM   702  O  O   . MET A 1 111 ? -6.547  -18.973 -31.834 0.50 35.85  ? 374  MET A O   1 
ATOM   703  C  CB  . MET A 1 111 ? -4.276  -18.943 -29.407 0.50 38.27  ? 374  MET A CB  1 
ATOM   704  C  CG  . MET A 1 111 ? -3.261  -19.891 -28.779 0.50 39.39  ? 374  MET A CG  1 
ATOM   705  S  SD  . MET A 1 111 ? -3.420  -20.068 -26.993 0.50 43.35  ? 374  MET A SD  1 
ATOM   706  C  CE  . MET A 1 111 ? -2.980  -18.417 -26.456 0.50 42.16  ? 374  MET A CE  1 
ATOM   707  N  N   . LYS A 1 112 ? -5.438  -16.993 -31.660 0.50 39.93  ? 375  LYS A N   1 
ATOM   708  C  CA  . LYS A 1 112 ? -6.565  -16.131 -32.117 0.50 41.26  ? 375  LYS A CA  1 
ATOM   709  C  C   . LYS A 1 112 ? -6.910  -16.487 -33.566 0.50 39.93  ? 375  LYS A C   1 
ATOM   710  O  O   . LYS A 1 112 ? -8.100  -16.687 -33.856 0.50 39.77  ? 375  LYS A O   1 
ATOM   711  C  CB  . LYS A 1 112 ? -6.210  -14.645 -31.997 0.50 48.43  ? 375  LYS A CB  1 
ATOM   712  C  CG  . LYS A 1 112 ? -7.224  -13.789 -31.244 0.50 52.69  ? 375  LYS A CG  1 
ATOM   713  C  CD  . LYS A 1 112 ? -6.976  -13.770 -29.745 0.50 56.70  ? 375  LYS A CD  1 
ATOM   714  C  CE  . LYS A 1 112 ? -8.137  -13.240 -28.930 0.50 58.72  ? 375  LYS A CE  1 
ATOM   715  N  NZ  . LYS A 1 112 ? -7.945  -13.499 -27.482 0.50 57.84  ? 375  LYS A NZ  1 
ATOM   716  N  N   . ILE A 1 113 ? -5.905  -16.575 -34.440 0.50 38.66  ? 376  ILE A N   1 
ATOM   717  C  CA  . ILE A 1 113 ? -6.088  -16.969 -35.868 0.50 39.64  ? 376  ILE A CA  1 
ATOM   718  C  C   . ILE A 1 113 ? -6.711  -18.366 -35.925 0.50 38.72  ? 376  ILE A C   1 
ATOM   719  O  O   . ILE A 1 113 ? -7.655  -18.577 -36.727 0.50 38.05  ? 376  ILE A O   1 
ATOM   720  C  CB  . ILE A 1 113 ? -4.755  -16.937 -36.637 0.50 40.77  ? 376  ILE A CB  1 
ATOM   721  C  CG1 . ILE A 1 113 ? -4.157  -15.532 -36.693 0.50 44.94  ? 376  ILE A CG1 1 
ATOM   722  C  CG2 . ILE A 1 113 ? -4.921  -17.515 -38.030 0.50 41.49  ? 376  ILE A CG2 1 
ATOM   723  C  CD1 . ILE A 1 113 ? -2.823  -15.485 -37.396 0.50 46.31  ? 376  ILE A CD1 1 
ATOM   724  N  N   . THR A 1 114 ? -6.168  -19.309 -35.149 0.50 36.81  ? 377  THR A N   1 
ATOM   725  C  CA  . THR A 1 114 ? -6.599  -20.732 -35.190 0.50 33.93  ? 377  THR A CA  1 
ATOM   726  C  C   . THR A 1 114 ? -8.033  -20.853 -34.668 0.50 31.35  ? 377  THR A C   1 
ATOM   727  O  O   . THR A 1 114 ? -8.836  -21.554 -35.319 0.50 32.24  ? 377  THR A O   1 
ATOM   728  C  CB  . THR A 1 114 ? -5.625  -21.623 -34.415 0.50 33.70  ? 377  THR A CB  1 
ATOM   729  O  OG1 . THR A 1 114 ? -4.345  -21.409 -35.005 0.50 31.92  ? 377  THR A OG1 1 
ATOM   730  C  CG2 . THR A 1 114 ? -5.992  -23.088 -34.488 0.50 32.65  ? 377  THR A CG2 1 
ATOM   731  N  N   . ALA A 1 115 ? -8.335  -20.203 -33.541 1.00 32.74  ? 378  ALA A N   1 
ATOM   732  C  CA  . ALA A 1 115 ? -9.692  -20.196 -32.936 1.00 32.81  ? 378  ALA A CA  1 
ATOM   733  C  C   . ALA A 1 115 ? -10.723 -19.568 -33.894 1.00 36.44  ? 378  ALA A C   1 
ATOM   734  O  O   . ALA A 1 115 ? -11.831 -20.163 -34.103 1.00 33.46  ? 378  ALA A O   1 
ATOM   735  C  CB  . ALA A 1 115 ? -9.667  -19.474 -31.640 1.00 34.68  ? 378  ALA A CB  1 
ATOM   736  N  N   . GLU A 1 116 ? -10.369 -18.445 -34.532 1.00 34.78  ? 379  GLU A N   1 
ATOM   737  C  CA  . GLU A 1 116 ? -11.286 -17.759 -35.482 1.00 39.25  ? 379  GLU A CA  1 
ATOM   738  C  C   . GLU A 1 116 ? -11.615 -18.751 -36.601 1.00 36.68  ? 379  GLU A C   1 
ATOM   739  O  O   . GLU A 1 116 ? -12.808 -18.975 -36.911 1.00 36.47  ? 379  GLU A O   1 
ATOM   740  C  CB  . GLU A 1 116 ? -10.642 -16.435 -35.935 1.00 43.21  ? 379  GLU A CB  1 
ATOM   741  C  CG  . GLU A 1 116 ? -11.459 -15.613 -36.910 1.00 54.00  ? 379  GLU A CG  1 
ATOM   742  C  CD  . GLU A 1 116 ? -10.667 -14.568 -37.700 1.00 57.17  ? 379  GLU A CD  1 
ATOM   743  O  OE1 . GLU A 1 116 ? -9.662  -14.051 -37.168 1.00 55.66  ? 379  GLU A OE1 1 
ATOM   744  O  OE2 . GLU A 1 116 ? -11.038 -14.308 -38.868 1.00 64.37  ? 379  GLU A OE2 1 
ATOM   745  N  N   . TRP A 1 117 ? -10.601 -19.391 -37.168 1.00 32.92  ? 380  TRP A N   1 
ATOM   746  C  CA  . TRP A 1 117 ? -10.751 -20.334 -38.282 1.00 30.25  ? 380  TRP A CA  1 
ATOM   747  C  C   . TRP A 1 117 ? -11.572 -21.556 -37.814 1.00 34.20  ? 380  TRP A C   1 
ATOM   748  O  O   . TRP A 1 117 ? -12.398 -22.068 -38.589 1.00 31.11  ? 380  TRP A O   1 
ATOM   749  C  CB  . TRP A 1 117 ? -9.361  -20.728 -38.776 1.00 36.85  ? 380  TRP A CB  1 
ATOM   750  C  CG  . TRP A 1 117 ? -9.450  -21.798 -39.802 1.00 31.08  ? 380  TRP A CG  1 
ATOM   751  C  CD1 . TRP A 1 117 ? -9.636  -21.614 -41.135 1.00 33.11  ? 380  TRP A CD1 1 
ATOM   752  C  CD2 . TRP A 1 117 ? -9.433  -23.212 -39.583 1.00 34.97  ? 380  TRP A CD2 1 
ATOM   753  N  NE1 . TRP A 1 117 ? -9.637  -22.808 -41.775 1.00 35.96  ? 380  TRP A NE1 1 
ATOM   754  C  CE2 . TRP A 1 117 ? -9.527  -23.817 -40.848 1.00 32.83  ? 380  TRP A CE2 1 
ATOM   755  C  CE3 . TRP A 1 117 ? -9.269  -24.023 -38.460 1.00 36.23  ? 380  TRP A CE3 1 
ATOM   756  C  CZ2 . TRP A 1 117 ? -9.551  -25.198 -41.023 1.00 37.26  ? 380  TRP A CZ2 1 
ATOM   757  C  CZ3 . TRP A 1 117 ? -9.244  -25.387 -38.637 1.00 31.42  ? 380  TRP A CZ3 1 
ATOM   758  C  CH2 . TRP A 1 117 ? -9.411  -25.969 -39.888 1.00 32.87  ? 380  TRP A CH2 1 
ATOM   759  N  N   . LEU A 1 118 ? -11.343 -22.036 -36.590 1.00 34.37  ? 381  LEU A N   1 
ATOM   760  C  CA  . LEU A 1 118 ? -11.996 -23.294 -36.126 1.00 32.90  ? 381  LEU A CA  1 
ATOM   761  C  C   . LEU A 1 118 ? -13.498 -23.066 -35.882 1.00 28.95  ? 381  LEU A C   1 
ATOM   762  O  O   . LEU A 1 118 ? -14.295 -23.898 -36.311 1.00 30.33  ? 381  LEU A O   1 
ATOM   763  C  CB  . LEU A 1 118 ? -11.273 -23.785 -34.867 1.00 33.19  ? 381  LEU A CB  1 
ATOM   764  C  CG  . LEU A 1 118 ? -11.745 -25.146 -34.341 1.00 34.04  ? 381  LEU A CG  1 
ATOM   765  C  CD1 . LEU A 1 118 ? -11.623 -26.201 -35.411 1.00 34.92  ? 381  LEU A CD1 1 
ATOM   766  C  CD2 . LEU A 1 118 ? -10.956 -25.528 -33.095 1.00 35.18  ? 381  LEU A CD2 1 
ATOM   767  N  N   . TRP A 1 119 ? -13.888 -21.960 -35.252 1.00 32.33  ? 382  TRP A N   1 
ATOM   768  C  CA  . TRP A 1 119 ? -15.335 -21.655 -35.044 1.00 34.05  ? 382  TRP A CA  1 
ATOM   769  C  C   . TRP A 1 119 ? -16.050 -21.503 -36.384 1.00 36.56  ? 382  TRP A C   1 
ATOM   770  O  O   . TRP A 1 119 ? -17.144 -22.084 -36.545 1.00 35.09  ? 382  TRP A O   1 
ATOM   771  C  CB  . TRP A 1 119 ? -15.525 -20.409 -34.209 1.00 35.13  ? 382  TRP A CB  1 
ATOM   772  C  CG  . TRP A 1 119 ? -15.302 -20.610 -32.760 1.00 30.04  ? 382  TRP A CG  1 
ATOM   773  C  CD1 . TRP A 1 119 ? -14.501 -19.858 -31.969 1.00 30.93  ? 382  TRP A CD1 1 
ATOM   774  C  CD2 . TRP A 1 119 ? -15.949 -21.562 -31.896 1.00 30.75  ? 382  TRP A CD2 1 
ATOM   775  N  NE1 . TRP A 1 119 ? -14.593 -20.263 -30.675 1.00 28.72  ? 382  TRP A NE1 1 
ATOM   776  C  CE2 . TRP A 1 119 ? -15.476 -21.307 -30.598 1.00 28.92  ? 382  TRP A CE2 1 
ATOM   777  C  CE3 . TRP A 1 119 ? -16.905 -22.567 -32.074 1.00 31.51  ? 382  TRP A CE3 1 
ATOM   778  C  CZ2 . TRP A 1 119 ? -15.851 -22.067 -29.496 1.00 28.36  ? 382  TRP A CZ2 1 
ATOM   779  C  CZ3 . TRP A 1 119 ? -17.299 -23.294 -30.977 1.00 29.66  ? 382  TRP A CZ3 1 
ATOM   780  C  CH2 . TRP A 1 119 ? -16.777 -23.053 -29.712 1.00 27.23  ? 382  TRP A CH2 1 
ATOM   781  N  N   . LYS A 1 120 ? -15.396 -20.892 -37.382 1.00 37.08  ? 383  LYS A N   1 
ATOM   782  C  CA  . LYS A 1 120 ? -15.978 -20.834 -38.737 1.00 36.67  ? 383  LYS A CA  1 
ATOM   783  C  C   . LYS A 1 120 ? -16.118 -22.227 -39.315 1.00 34.84  ? 383  LYS A C   1 
ATOM   784  O  O   . LYS A 1 120 ? -17.186 -22.507 -39.898 1.00 33.80  ? 383  LYS A O   1 
ATOM   785  C  CB  . LYS A 1 120 ? -15.170 -19.959 -39.700 1.00 47.09  ? 383  LYS A CB  1 
ATOM   786  C  CG  . LYS A 1 120 ? -15.149 -18.492 -39.327 1.00 54.45  ? 383  LYS A CG  1 
ATOM   787  C  CD  . LYS A 1 120 ? -14.569 -17.591 -40.399 1.00 65.02  ? 383  LYS A CD  1 
ATOM   788  C  CE  . LYS A 1 120 ? -14.476 -16.153 -39.925 1.00 68.76  ? 383  LYS A CE  1 
ATOM   789  N  NZ  . LYS A 1 120 ? -13.141 -15.582 -40.230 1.00 76.69  ? 383  LYS A NZ  1 
ATOM   790  N  N   . GLU A 1 121 ? -15.129 -23.117 -39.193 1.00 32.54  ? 384  GLU A N   1 
ATOM   791  C  CA  . GLU A 1 121 ? -15.301 -24.456 -39.789 1.00 31.48  ? 384  GLU A CA  1 
ATOM   792  C  C   . GLU A 1 121 ? -16.431 -25.182 -39.074 1.00 30.05  ? 384  GLU A C   1 
ATOM   793  O  O   . GLU A 1 121 ? -17.173 -25.906 -39.749 1.00 35.68  ? 384  GLU A O   1 
ATOM   794  C  CB  . GLU A 1 121 ? -14.096 -25.400 -39.630 1.00 35.23  ? 384  GLU A CB  1 
ATOM   795  C  CG  . GLU A 1 121 ? -12.946 -25.026 -40.476 1.00 43.20  ? 384  GLU A CG  1 
ATOM   796  C  CD  . GLU A 1 121 ? -13.179 -25.024 -41.975 1.00 39.95  ? 384  GLU A CD  1 
ATOM   797  O  OE1 . GLU A 1 121 ? -13.607 -26.069 -42.558 1.00 41.43  ? 384  GLU A OE1 1 
ATOM   798  O  OE2 . GLU A 1 121 ? -12.879 -23.981 -42.540 1.00 46.41  ? 384  GLU A OE2 1 
ATOM   799  N  N   . LEU A 1 122 ? -16.472 -25.086 -37.746 1.00 31.08  ? 385  LEU A N   1 
ATOM   800  C  CA  . LEU A 1 122 ? -17.451 -25.878 -36.939 1.00 29.67  ? 385  LEU A CA  1 
ATOM   801  C  C   . LEU A 1 122 ? -18.871 -25.361 -37.277 1.00 31.79  ? 385  LEU A C   1 
ATOM   802  O  O   . LEU A 1 122 ? -19.863 -26.151 -37.185 1.00 29.80  ? 385  LEU A O   1 
ATOM   803  C  CB  . LEU A 1 122 ? -17.143 -25.695 -35.455 1.00 30.64  ? 385  LEU A CB  1 
ATOM   804  C  CG  . LEU A 1 122 ? -15.887 -26.425 -34.953 1.00 30.09  ? 385  LEU A CG  1 
ATOM   805  C  CD1 . LEU A 1 122 ? -15.660 -26.155 -33.487 1.00 31.53  ? 385  LEU A CD1 1 
ATOM   806  C  CD2 . LEU A 1 122 ? -16.011 -27.915 -35.246 1.00 31.89  ? 385  LEU A CD2 1 
ATOM   807  N  N   . GLY A 1 123 ? -18.952 -24.075 -37.612 1.00 33.21  ? 386  GLY A N   1 
ATOM   808  C  CA  . GLY A 1 123 ? -20.222 -23.362 -37.894 1.00 38.43  ? 386  GLY A CA  1 
ATOM   809  C  C   . GLY A 1 123 ? -20.667 -23.425 -39.347 1.00 43.03  ? 386  GLY A C   1 
ATOM   810  O  O   . GLY A 1 123 ? -21.797 -22.985 -39.606 1.00 41.45  ? 386  GLY A O   1 
ATOM   811  N  N   . LYS A 1 124 ? -19.875 -23.965 -40.273 1.00 39.42  ? 387  LYS A N   1 
ATOM   812  C  CA  . LYS A 1 124 ? -20.269 -24.062 -41.705 1.00 44.78  ? 387  LYS A CA  1 
ATOM   813  C  C   . LYS A 1 124 ? -21.579 -24.839 -41.889 1.00 47.57  ? 387  LYS A C   1 
ATOM   814  O  O   . LYS A 1 124 ? -22.371 -24.425 -42.730 1.00 48.65  ? 387  LYS A O   1 
ATOM   815  C  CB  . LYS A 1 124 ? -19.165 -24.670 -42.566 1.00 45.18  ? 387  LYS A CB  1 
ATOM   816  C  CG  . LYS A 1 124 ? -17.992 -23.743 -42.867 1.00 50.02  ? 387  LYS A CG  1 
ATOM   817  C  CD  . LYS A 1 124 ? -17.084 -24.306 -43.946 1.00 55.54  ? 387  LYS A CD  1 
ATOM   818  C  CE  . LYS A 1 124 ? -15.721 -23.656 -44.036 1.00 57.16  ? 387  LYS A CE  1 
ATOM   819  N  NZ  . LYS A 1 124 ? -14.757 -24.581 -44.683 1.00 61.37  ? 387  LYS A NZ  1 
ATOM   820  N  N   . LYS A 1 125 ? -21.805 -25.942 -41.182 1.00 39.20  ? 388  LYS A N   1 
ATOM   821  C  CA  . LYS A 1 125 ? -23.011 -26.772 -41.391 1.00 38.59  ? 388  LYS A CA  1 
ATOM   822  C  C   . LYS A 1 125 ? -23.895 -26.800 -40.144 1.00 32.69  ? 388  LYS A C   1 
ATOM   823  O  O   . LYS A 1 125 ? -24.706 -27.692 -40.038 1.00 37.53  ? 388  LYS A O   1 
ATOM   824  C  CB  . LYS A 1 125 ? -22.576 -28.166 -41.801 1.00 41.00  ? 388  LYS A CB  1 
ATOM   825  C  CG  . LYS A 1 125 ? -21.917 -28.252 -43.170 1.00 50.54  ? 388  LYS A CG  1 
ATOM   826  C  CD  . LYS A 1 125 ? -21.363 -29.649 -43.441 1.00 59.31  ? 388  LYS A CD  1 
ATOM   827  C  CE  . LYS A 1 125 ? -20.102 -29.962 -42.656 1.00 67.73  ? 388  LYS A CE  1 
ATOM   828  N  NZ  . LYS A 1 125 ? -19.966 -31.417 -42.378 1.00 73.65  ? 388  LYS A NZ  1 
ATOM   829  N  N   . LYS A 1 126 ? -23.730 -25.861 -39.224 1.00 32.70  ? 389  LYS A N   1 
ATOM   830  C  CA  . LYS A 1 126 ? -24.525 -25.837 -37.986 1.00 35.83  ? 389  LYS A CA  1 
ATOM   831  C  C   . LYS A 1 126 ? -25.021 -24.416 -37.776 1.00 39.57  ? 389  LYS A C   1 
ATOM   832  O  O   . LYS A 1 126 ? -24.244 -23.495 -38.054 1.00 43.91  ? 389  LYS A O   1 
ATOM   833  C  CB  . LYS A 1 126 ? -23.677 -26.207 -36.761 1.00 34.42  ? 389  LYS A CB  1 
ATOM   834  C  CG  . LYS A 1 126 ? -23.080 -27.600 -36.811 1.00 33.49  ? 389  LYS A CG  1 
ATOM   835  C  CD  . LYS A 1 126 ? -24.057 -28.647 -36.367 1.00 34.99  ? 389  LYS A CD  1 
ATOM   836  C  CE  . LYS A 1 126 ? -23.439 -30.017 -36.399 1.00 35.71  ? 389  LYS A CE  1 
ATOM   837  N  NZ  . LYS A 1 126 ? -24.486 -31.048 -36.480 1.00 35.68  ? 389  LYS A NZ  1 
ATOM   838  N  N   . THR A 1 127 ? -26.157 -24.278 -37.084 1.00 37.22  ? 390  THR A N   1 
ATOM   839  C  CA  . THR A 1 127 ? -26.717 -22.956 -36.691 1.00 38.33  ? 390  THR A CA  1 
ATOM   840  C  C   . THR A 1 127 ? -26.792 -22.819 -35.184 1.00 29.66  ? 390  THR A C   1 
ATOM   841  O  O   . THR A 1 127 ? -27.558 -23.514 -34.554 1.00 36.01  ? 390  THR A O   1 
ATOM   842  C  CB  . THR A 1 127 ? -28.147 -22.795 -37.236 1.00 47.13  ? 390  THR A CB  1 
ATOM   843  O  OG1 . THR A 1 127 ? -27.976 -22.842 -38.649 1.00 43.73  ? 390  THR A OG1 1 
ATOM   844  C  CG2 . THR A 1 127 ? -28.827 -21.527 -36.758 1.00 43.79  ? 390  THR A CG2 1 
ATOM   845  N  N   . PRO A 1 128 ? -26.064 -21.892 -34.559 1.00 29.36  ? 391  PRO A N   1 
ATOM   846  C  CA  . PRO A 1 128 ? -26.191 -21.669 -33.130 1.00 32.98  ? 391  PRO A CA  1 
ATOM   847  C  C   . PRO A 1 128 ? -27.630 -21.244 -32.795 1.00 38.24  ? 391  PRO A C   1 
ATOM   848  O  O   . PRO A 1 128 ? -28.245 -20.510 -33.566 1.00 40.55  ? 391  PRO A O   1 
ATOM   849  C  CB  . PRO A 1 128 ? -25.233 -20.521 -32.819 1.00 29.84  ? 391  PRO A CB  1 
ATOM   850  C  CG  . PRO A 1 128 ? -24.347 -20.429 -34.010 1.00 30.81  ? 391  PRO A CG  1 
ATOM   851  C  CD  . PRO A 1 128 ? -25.107 -20.980 -35.181 1.00 31.64  ? 391  PRO A CD  1 
ATOM   852  N  N   . ARG A 1 129 ? -28.130 -21.716 -31.668 1.00 35.66  ? 392  ARG A N   1 
ATOM   853  C  CA  . ARG A 1 129 ? -29.556 -21.517 -31.285 1.00 35.74  ? 392  ARG A CA  1 
ATOM   854  C  C   . ARG A 1 129 ? -29.675 -21.685 -29.774 1.00 46.40  ? 392  ARG A C   1 
ATOM   855  O  O   . ARG A 1 129 ? -28.812 -22.356 -29.159 1.00 36.74  ? 392  ARG A O   1 
ATOM   856  C  CB  . ARG A 1 129 ? -30.501 -22.406 -32.097 1.00 36.31  ? 392  ARG A CB  1 
ATOM   857  C  CG  . ARG A 1 129 ? -30.285 -23.915 -32.047 1.00 35.84  ? 392  ARG A CG  1 
ATOM   858  C  CD  . ARG A 1 129 ? -31.118 -24.599 -31.029 1.00 39.73  ? 392  ARG A CD  1 
ATOM   859  N  NE  . ARG A 1 129 ? -30.828 -26.014 -30.836 1.00 34.40  ? 392  ARG A NE  1 
ATOM   860  C  CZ  . ARG A 1 129 ? -31.397 -26.727 -29.879 1.00 35.87  ? 392  ARG A CZ  1 
ATOM   861  N  NH1 . ARG A 1 129 ? -32.329 -26.176 -29.118 1.00 38.21  ? 392  ARG A NH1 1 
ATOM   862  N  NH2 . ARG A 1 129 ? -31.132 -28.007 -29.754 1.00 37.11  ? 392  ARG A NH2 1 
ATOM   863  N  N   . MET A 1 130 ? -30.694 -21.054 -29.183 1.00 43.59  ? 393  MET A N   1 
ATOM   864  C  CA  . MET A 1 130 ? -30.983 -21.202 -27.748 1.00 44.06  ? 393  MET A CA  1 
ATOM   865  C  C   . MET A 1 130 ? -31.634 -22.547 -27.521 1.00 43.97  ? 393  MET A C   1 
ATOM   866  O  O   . MET A 1 130 ? -32.381 -23.036 -28.387 1.00 45.77  ? 393  MET A O   1 
ATOM   867  C  CB  . MET A 1 130 ? -31.878 -20.076 -27.230 1.00 55.46  ? 393  MET A CB  1 
ATOM   868  C  CG  . MET A 1 130 ? -31.186 -18.734 -27.280 1.00 58.92  ? 393  MET A CG  1 
ATOM   869  S  SD  . MET A 1 130 ? -32.083 -17.390 -26.444 1.00 72.43  ? 393  MET A SD  1 
ATOM   870  C  CE  . MET A 1 130 ? -33.765 -17.761 -26.954 1.00 69.64  ? 393  MET A CE  1 
ATOM   871  N  N   . CYS A 1 131 ? -31.280 -23.159 -26.405 1.00 38.45  ? 394  CYS A N   1 
ATOM   872  C  CA  . CYS A 1 131 ? -31.952 -24.349 -25.868 1.00 40.57  ? 394  CYS A CA  1 
ATOM   873  C  C   . CYS A 1 131 ? -33.091 -23.835 -24.960 1.00 41.86  ? 394  CYS A C   1 
ATOM   874  O  O   . CYS A 1 131 ? -33.034 -22.651 -24.530 1.00 44.53  ? 394  CYS A O   1 
ATOM   875  C  CB  . CYS A 1 131 ? -30.937 -25.261 -25.199 1.00 43.57  ? 394  CYS A CB  1 
ATOM   876  S  SG  . CYS A 1 131 ? -29.802 -26.091 -26.359 1.00 41.86  ? 394  CYS A SG  1 
ATOM   877  N  N   . THR A 1 132 ? -34.147 -24.616 -24.783 1.00 49.46  ? 395  THR A N   1 
ATOM   878  C  CA  . THR A 1 132 ? -35.432 -24.072 -24.262 1.00 52.55  ? 395  THR A CA  1 
ATOM   879  C  C   . THR A 1 132 ? -35.760 -24.697 -22.912 1.00 48.68  ? 395  THR A C   1 
ATOM   880  O  O   . THR A 1 132 ? -35.283 -25.816 -22.653 1.00 43.26  ? 395  THR A O   1 
ATOM   881  C  CB  . THR A 1 132 ? -36.551 -24.299 -25.277 1.00 50.52  ? 395  THR A CB  1 
ATOM   882  O  OG1 . THR A 1 132 ? -36.600 -25.709 -25.479 1.00 46.70  ? 395  THR A OG1 1 
ATOM   883  C  CG2 . THR A 1 132 ? -36.327 -23.543 -26.572 1.00 51.17  ? 395  THR A CG2 1 
ATOM   884  N  N   . ARG A 1 133 ? -36.579 -23.997 -22.118 1.00 54.42  ? 396  ARG A N   1 
ATOM   885  C  CA  . ARG A 1 133 ? -37.166 -24.523 -20.847 1.00 54.75  ? 396  ARG A CA  1 
ATOM   886  C  C   . ARG A 1 133 ? -37.699 -25.921 -21.115 1.00 50.91  ? 396  ARG A C   1 
ATOM   887  O  O   . ARG A 1 133 ? -37.424 -26.838 -20.306 1.00 57.28  ? 396  ARG A O   1 
ATOM   888  C  CB  . ARG A 1 133 ? -38.289 -23.624 -20.316 1.00 57.96  ? 396  ARG A CB  1 
ATOM   889  C  CG  . ARG A 1 133 ? -37.890 -22.163 -20.231 1.00 61.49  ? 396  ARG A CG  1 
ATOM   890  C  CD  . ARG A 1 133 ? -38.639 -21.319 -19.227 1.00 70.54  ? 396  ARG A CD  1 
ATOM   891  N  NE  . ARG A 1 133 ? -37.899 -20.088 -18.973 1.00 72.27  ? 396  ARG A NE  1 
ATOM   892  C  CZ  . ARG A 1 133 ? -38.353 -19.045 -18.281 1.00 81.59  ? 396  ARG A CZ  1 
ATOM   893  N  NH1 . ARG A 1 133 ? -39.586 -19.051 -17.795 1.00 79.96  ? 396  ARG A NH1 1 
ATOM   894  N  NH2 . ARG A 1 133 ? -37.573 -17.987 -18.105 1.00 75.91  ? 396  ARG A NH2 1 
ATOM   895  N  N   . GLU A 1 134 ? -38.375 -26.094 -22.253 1.00 53.16  ? 397  GLU A N   1 
ATOM   896  C  CA  . GLU A 1 134 ? -39.003 -27.379 -22.626 1.00 57.70  ? 397  GLU A CA  1 
ATOM   897  C  C   . GLU A 1 134 ? -37.897 -28.430 -22.668 1.00 56.54  ? 397  GLU A C   1 
ATOM   898  O  O   . GLU A 1 134 ? -38.013 -29.393 -21.944 1.00 55.65  ? 397  GLU A O   1 
ATOM   899  C  CB  . GLU A 1 134 ? -39.772 -27.250 -23.944 1.00 68.94  ? 397  GLU A CB  1 
ATOM   900  C  CG  . GLU A 1 134 ? -41.078 -26.471 -23.831 1.00 75.05  ? 397  GLU A CG  1 
ATOM   901  C  CD  . GLU A 1 134 ? -41.000 -24.960 -23.610 1.00 79.86  ? 397  GLU A CD  1 
ATOM   902  O  OE1 . GLU A 1 134 ? -39.944 -24.326 -23.953 1.00 60.14  ? 397  GLU A OE1 1 
ATOM   903  O  OE2 . GLU A 1 134 ? -42.016 -24.403 -23.107 1.00 81.59  ? 397  GLU A OE2 1 
ATOM   904  N  N   . GLU A 1 135 ? -36.830 -28.209 -23.453 1.00 61.88  ? 398  GLU A N   1 
ATOM   905  C  CA  . GLU A 1 135 ? -35.682 -29.161 -23.583 1.00 60.37  ? 398  GLU A CA  1 
ATOM   906  C  C   . GLU A 1 135 ? -35.005 -29.450 -22.236 1.00 57.44  ? 398  GLU A C   1 
ATOM   907  O  O   . GLU A 1 135 ? -34.652 -30.615 -21.985 1.00 56.46  ? 398  GLU A O   1 
ATOM   908  C  CB  . GLU A 1 135 ? -34.586 -28.629 -24.507 1.00 55.92  ? 398  GLU A CB  1 
ATOM   909  C  CG  . GLU A 1 135 ? -34.788 -29.054 -25.939 1.00 60.20  ? 398  GLU A CG  1 
ATOM   910  C  CD  . GLU A 1 135 ? -33.824 -28.411 -26.914 1.00 56.75  ? 398  GLU A CD  1 
ATOM   911  O  OE1 . GLU A 1 135 ? -33.569 -27.208 -26.756 1.00 46.48  ? 398  GLU A OE1 1 
ATOM   912  O  OE2 . GLU A 1 135 ? -33.334 -29.140 -27.818 1.00 56.44  ? 398  GLU A OE2 1 
ATOM   913  N  N   . PHE A 1 136 ? -34.813 -28.407 -21.419 0.50 56.32  ? 399  PHE A N   1 
ATOM   914  C  CA  . PHE A 1 136 ? -34.136 -28.467 -20.095 0.50 56.98  ? 399  PHE A CA  1 
ATOM   915  C  C   . PHE A 1 136 ? -34.966 -29.303 -19.114 0.50 58.80  ? 399  PHE A C   1 
ATOM   916  O  O   . PHE A 1 136 ? -34.379 -30.121 -18.376 0.50 56.64  ? 399  PHE A O   1 
ATOM   917  C  CB  . PHE A 1 136 ? -33.904 -27.061 -19.536 0.50 56.57  ? 399  PHE A CB  1 
ATOM   918  C  CG  . PHE A 1 136 ? -33.152 -27.037 -18.228 0.50 58.22  ? 399  PHE A CG  1 
ATOM   919  C  CD1 . PHE A 1 136 ? -31.844 -27.491 -18.155 0.50 56.66  ? 399  PHE A CD1 1 
ATOM   920  C  CD2 . PHE A 1 136 ? -33.753 -26.569 -17.070 0.50 57.22  ? 399  PHE A CD2 1 
ATOM   921  C  CE1 . PHE A 1 136 ? -31.151 -27.464 -16.956 0.50 56.59  ? 399  PHE A CE1 1 
ATOM   922  C  CE2 . PHE A 1 136 ? -33.060 -26.545 -15.871 0.50 56.23  ? 399  PHE A CE2 1 
ATOM   923  C  CZ  . PHE A 1 136 ? -31.760 -26.993 -15.816 0.50 57.65  ? 399  PHE A CZ  1 
ATOM   924  N  N   . THR A 1 137 ? -36.287 -29.099 -19.099 0.50 59.24  ? 400  THR A N   1 
ATOM   925  C  CA  . THR A 1 137 ? -37.229 -29.813 -18.197 0.50 61.33  ? 400  THR A CA  1 
ATOM   926  C  C   . THR A 1 137 ? -37.237 -31.301 -18.560 0.50 62.74  ? 400  THR A C   1 
ATOM   927  O  O   . THR A 1 137 ? -37.257 -32.131 -17.634 0.50 61.01  ? 400  THR A O   1 
ATOM   928  C  CB  . THR A 1 137 ? -38.633 -29.199 -18.242 0.50 58.96  ? 400  THR A CB  1 
ATOM   929  O  OG1 . THR A 1 137 ? -38.528 -27.847 -17.794 0.50 60.04  ? 400  THR A OG1 1 
ATOM   930  C  CG2 . THR A 1 137 ? -39.623 -29.949 -17.380 0.50 59.08  ? 400  THR A CG2 1 
ATOM   931  N  N   . ARG A 1 138 ? -37.201 -31.625 -19.854 0.50 66.79  ? 401  ARG A N   1 
ATOM   932  C  CA  . ARG A 1 138 ? -37.237 -33.031 -20.336 0.50 69.03  ? 401  ARG A CA  1 
ATOM   933  C  C   . ARG A 1 138 ? -35.977 -33.760 -19.856 0.50 69.43  ? 401  ARG A C   1 
ATOM   934  O  O   . ARG A 1 138 ? -36.077 -34.957 -19.533 0.50 70.61  ? 401  ARG A O   1 
ATOM   935  C  CB  . ARG A 1 138 ? -37.370 -33.077 -21.861 0.50 74.73  ? 401  ARG A CB  1 
ATOM   936  C  CG  . ARG A 1 138 ? -37.800 -34.435 -22.395 0.50 77.40  ? 401  ARG A CG  1 
ATOM   937  C  CD  . ARG A 1 138 ? -38.582 -34.326 -23.690 0.50 77.71  ? 401  ARG A CD  1 
ATOM   938  N  NE  . ARG A 1 138 ? -37.763 -33.807 -24.775 0.50 80.76  ? 401  ARG A NE  1 
ATOM   939  C  CZ  . ARG A 1 138 ? -37.135 -34.557 -25.675 0.50 81.08  ? 401  ARG A CZ  1 
ATOM   940  N  NH1 . ARG A 1 138 ? -37.231 -35.875 -25.625 0.50 81.10  ? 401  ARG A NH1 1 
ATOM   941  N  NH2 . ARG A 1 138 ? -36.417 -33.984 -26.625 0.50 81.29  ? 401  ARG A NH2 1 
ATOM   942  N  N   . LYS A 1 139 ? -34.841 -33.059 -19.796 0.50 68.89  ? 402  LYS A N   1 
ATOM   943  C  CA  . LYS A 1 139 ? -33.531 -33.628 -19.380 0.50 67.68  ? 402  LYS A CA  1 
ATOM   944  C  C   . LYS A 1 139 ? -33.545 -33.896 -17.870 0.50 71.18  ? 402  LYS A C   1 
ATOM   945  O  O   . LYS A 1 139 ? -32.949 -34.907 -17.444 0.50 69.82  ? 402  LYS A O   1 
ATOM   946  C  CB  . LYS A 1 139 ? -32.388 -32.679 -19.753 0.50 65.36  ? 402  LYS A CB  1 
ATOM   947  C  CG  . LYS A 1 139 ? -32.213 -32.436 -21.246 0.50 63.85  ? 402  LYS A CG  1 
ATOM   948  C  CD  . LYS A 1 139 ? -31.145 -31.410 -21.575 0.50 62.12  ? 402  LYS A CD  1 
ATOM   949  C  CE  . LYS A 1 139 ? -29.744 -31.979 -21.530 0.50 59.01  ? 402  LYS A CE  1 
ATOM   950  N  NZ  . LYS A 1 139 ? -29.587 -33.109 -22.477 0.50 57.07  ? 402  LYS A NZ  1 
ATOM   951  N  N   . VAL A 1 140 ? -34.193 -33.021 -17.095 0.50 74.47  ? 403  VAL A N   1 
ATOM   952  C  CA  . VAL A 1 140 ? -34.249 -33.103 -15.604 0.50 78.28  ? 403  VAL A CA  1 
ATOM   953  C  C   . VAL A 1 140 ? -35.202 -34.236 -15.207 0.50 83.00  ? 403  VAL A C   1 
ATOM   954  O  O   . VAL A 1 140 ? -34.955 -34.869 -14.157 0.50 84.38  ? 403  VAL A O   1 
ATOM   955  C  CB  . VAL A 1 140 ? -34.677 -31.766 -14.967 0.50 76.96  ? 403  VAL A CB  1 
ATOM   956  C  CG1 . VAL A 1 140 ? -33.926 -30.585 -15.564 0.50 75.64  ? 403  VAL A CG1 1 
ATOM   957  C  CG2 . VAL A 1 140 ? -36.178 -31.551 -15.062 0.50 78.03  ? 403  VAL A CG2 1 
ATOM   958  N  N   . ARG A 1 141 ? -36.246 -34.474 -16.011 0.50 86.72  ? 404  ARG A N   1 
ATOM   959  C  CA  . ARG A 1 141 ? -37.281 -35.517 -15.767 0.50 88.43  ? 404  ARG A CA  1 
ATOM   960  C  C   . ARG A 1 141 ? -36.798 -36.858 -16.328 0.50 87.45  ? 404  ARG A C   1 
ATOM   961  O  O   . ARG A 1 141 ? -37.543 -37.848 -16.210 0.50 89.49  ? 404  ARG A O   1 
ATOM   962  C  CB  . ARG A 1 141 ? -38.623 -35.120 -16.391 0.50 89.30  ? 404  ARG A CB  1 
ATOM   963  C  CG  . ARG A 1 141 ? -39.395 -34.088 -15.582 0.50 92.22  ? 404  ARG A CG  1 
ATOM   964  C  CD  . ARG A 1 141 ? -40.896 -34.296 -15.650 0.50 95.81  ? 404  ARG A CD  1 
ATOM   965  N  NE  . ARG A 1 141 ? -41.490 -33.767 -16.871 0.50 98.30  ? 404  ARG A NE  1 
ATOM   966  C  CZ  . ARG A 1 141 ? -42.047 -32.566 -16.975 0.50 99.86  ? 404  ARG A CZ  1 
ATOM   967  N  NH1 . ARG A 1 141 ? -42.084 -31.761 -15.926 0.50 99.46  ? 404  ARG A NH1 1 
ATOM   968  N  NH2 . ARG A 1 141 ? -42.568 -32.173 -18.124 0.50 100.17 ? 404  ARG A NH2 1 
ATOM   969  N  N   . SER A 1 142 ? -35.594 -36.878 -16.908 0.50 88.08  ? 405  SER A N   1 
ATOM   970  C  CA  . SER A 1 142 ? -34.941 -38.083 -17.482 0.50 89.20  ? 405  SER A CA  1 
ATOM   971  C  C   . SER A 1 142 ? -33.657 -38.395 -16.703 0.50 89.23  ? 405  SER A C   1 
ATOM   972  O  O   . SER A 1 142 ? -32.935 -39.326 -17.106 0.50 90.35  ? 405  SER A O   1 
ATOM   973  C  CB  . SER A 1 142 ? -34.665 -37.898 -18.951 0.50 89.99  ? 405  SER A CB  1 
ATOM   974  O  OG  . SER A 1 142 ? -34.027 -36.653 -19.192 0.50 88.74  ? 405  SER A OG  1 
ATOM   975  N  N   . ASN A 1 143 ? -33.391 -37.634 -15.636 0.50 89.77  ? 406  ASN A N   1 
ATOM   976  C  CA  . ASN A 1 143 ? -32.261 -37.850 -14.690 0.50 90.74  ? 406  ASN A CA  1 
ATOM   977  C  C   . ASN A 1 143 ? -30.928 -37.787 -15.446 0.50 88.65  ? 406  ASN A C   1 
ATOM   978  O  O   . ASN A 1 143 ? -30.568 -38.788 -16.096 0.50 90.36  ? 406  ASN A O   1 
ATOM   979  C  CB  . ASN A 1 143 ? -32.403 -39.179 -13.941 0.50 91.72  ? 406  ASN A CB  1 
ATOM   980  C  CG  . ASN A 1 143 ? -31.201 -39.509 -13.079 0.50 89.59  ? 406  ASN A CG  1 
ATOM   981  O  OD1 . ASN A 1 143 ? -30.419 -38.629 -12.730 0.50 91.44  ? 406  ASN A OD1 1 
ATOM   982  N  ND2 . ASN A 1 143 ? -31.045 -40.776 -12.730 0.50 89.35  ? 406  ASN A ND2 1 
ATOM   983  N  N   . ALA A 1 144 ? -30.221 -36.658 -15.343 0.50 88.77  ? 407  ALA A N   1 
ATOM   984  C  CA  . ALA A 1 144 ? -28.881 -36.428 -15.934 0.50 88.13  ? 407  ALA A CA  1 
ATOM   985  C  C   . ALA A 1 144 ? -28.079 -35.495 -15.018 0.50 88.15  ? 407  ALA A C   1 
ATOM   986  O  O   . ALA A 1 144 ? -28.693 -34.604 -14.395 0.50 85.68  ? 407  ALA A O   1 
ATOM   987  C  CB  . ALA A 1 144 ? -29.019 -35.861 -17.327 0.50 86.84  ? 407  ALA A CB  1 
ATOM   988  N  N   . ALA A 1 145 ? -26.759 -35.699 -14.949 0.50 87.21  ? 408  ALA A N   1 
ATOM   989  C  CA  . ALA A 1 145 ? -25.818 -34.970 -14.066 0.50 88.35  ? 408  ALA A CA  1 
ATOM   990  C  C   . ALA A 1 145 ? -25.675 -33.513 -14.525 0.50 88.78  ? 408  ALA A C   1 
ATOM   991  O  O   . ALA A 1 145 ? -24.598 -33.159 -15.047 0.50 91.97  ? 408  ALA A O   1 
ATOM   992  C  CB  . ALA A 1 145 ? -24.485 -35.678 -14.055 0.50 87.49  ? 408  ALA A CB  1 
ATOM   993  N  N   . LEU A 1 146 ? -26.717 -32.700 -14.317 0.50 86.42  ? 409  LEU A N   1 
ATOM   994  C  CA  . LEU A 1 146 ? -26.741 -31.250 -14.652 0.50 83.60  ? 409  LEU A CA  1 
ATOM   995  C  C   . LEU A 1 146 ? -25.814 -30.491 -13.696 0.50 80.29  ? 409  LEU A C   1 
ATOM   996  O  O   . LEU A 1 146 ? -25.654 -29.266 -13.878 0.50 79.24  ? 409  LEU A O   1 
ATOM   997  C  CB  . LEU A 1 146 ? -28.179 -30.734 -14.549 0.50 85.78  ? 409  LEU A CB  1 
ATOM   998  C  CG  . LEU A 1 146 ? -29.147 -31.278 -15.599 0.50 87.08  ? 409  LEU A CG  1 
ATOM   999  C  CD1 . LEU A 1 146 ? -30.580 -30.894 -15.265 0.50 87.40  ? 409  LEU A CD1 1 
ATOM   1000 C  CD2 . LEU A 1 146 ? -28.775 -30.789 -16.990 0.50 85.75  ? 409  LEU A CD2 1 
ATOM   1001 N  N   . GLY A 1 147 ? -25.241 -31.198 -12.717 0.66 74.87  ? 410  GLY A N   1 
ATOM   1002 C  CA  . GLY A 1 147 ? -24.277 -30.656 -11.739 0.66 74.14  ? 410  GLY A CA  1 
ATOM   1003 C  C   . GLY A 1 147 ? -24.870 -29.529 -10.909 0.66 73.31  ? 410  GLY A C   1 
ATOM   1004 O  O   . GLY A 1 147 ? -24.143 -28.552 -10.638 0.66 65.30  ? 410  GLY A O   1 
ATOM   1005 N  N   . ALA A 1 148 ? -26.140 -29.659 -10.506 0.50 73.22  ? 411  ALA A N   1 
ATOM   1006 C  CA  . ALA A 1 148 ? -26.879 -28.655 -9.703  0.50 74.25  ? 411  ALA A CA  1 
ATOM   1007 C  C   . ALA A 1 148 ? -26.774 -29.002 -8.212  0.50 75.86  ? 411  ALA A C   1 
ATOM   1008 O  O   . ALA A 1 148 ? -26.364 -30.137 -7.895  0.50 72.10  ? 411  ALA A O   1 
ATOM   1009 C  CB  . ALA A 1 148 ? -28.317 -28.580 -10.155 0.50 73.16  ? 411  ALA A CB  1 
ATOM   1010 N  N   . ILE A 1 149 ? -27.123 -28.048 -7.340  0.50 77.26  ? 412  ILE A N   1 
ATOM   1011 C  CA  . ILE A 1 149 ? -27.205 -28.229 -5.859  0.50 78.58  ? 412  ILE A CA  1 
ATOM   1012 C  C   . ILE A 1 149 ? -28.642 -28.621 -5.499  0.50 79.33  ? 412  ILE A C   1 
ATOM   1013 O  O   . ILE A 1 149 ? -29.435 -27.689 -5.254  0.50 80.23  ? 412  ILE A O   1 
ATOM   1014 C  CB  . ILE A 1 149 ? -26.772 -26.952 -5.110  0.50 79.04  ? 412  ILE A CB  1 
ATOM   1015 C  CG1 . ILE A 1 149 ? -27.702 -25.774 -5.414  0.50 79.80  ? 412  ILE A CG1 1 
ATOM   1016 C  CG2 . ILE A 1 149 ? -25.318 -26.618 -5.405  0.50 79.42  ? 412  ILE A CG2 1 
ATOM   1017 C  CD1 . ILE A 1 149 ? -27.776 -24.742 -4.308  0.50 79.92  ? 412  ILE A CD1 1 
ATOM   1018 N  N   . LYS A 1 155 ? -36.235 -24.950 -0.343  0.50 67.41  ? 418  LYS A N   1 
ATOM   1019 C  CA  . LYS A 1 155 ? -37.365 -24.374 -1.122  0.50 70.58  ? 418  LYS A CA  1 
ATOM   1020 C  C   . LYS A 1 155 ? -37.902 -25.437 -2.090  0.50 69.71  ? 418  LYS A C   1 
ATOM   1021 O  O   . LYS A 1 155 ? -39.138 -25.558 -2.209  0.50 72.94  ? 418  LYS A O   1 
ATOM   1022 C  CB  . LYS A 1 155 ? -36.908 -23.118 -1.873  0.50 71.58  ? 418  LYS A CB  1 
ATOM   1023 C  CG  . LYS A 1 155 ? -38.000 -22.089 -2.134  0.50 71.48  ? 418  LYS A CG  1 
ATOM   1024 C  CD  . LYS A 1 155 ? -39.319 -22.701 -2.552  0.50 70.52  ? 418  LYS A CD  1 
ATOM   1025 C  CE  . LYS A 1 155 ? -40.490 -21.756 -2.384  0.50 70.27  ? 418  LYS A CE  1 
ATOM   1026 N  NZ  . LYS A 1 155 ? -41.785 -22.464 -2.521  0.50 70.89  ? 418  LYS A NZ  1 
ATOM   1027 N  N   . TRP A 1 156 ? -36.998 -26.162 -2.758  0.50 68.05  ? 419  TRP A N   1 
ATOM   1028 C  CA  . TRP A 1 156 ? -37.294 -27.331 -3.632  0.50 67.38  ? 419  TRP A CA  1 
ATOM   1029 C  C   . TRP A 1 156 ? -36.325 -28.462 -3.283  0.50 70.00  ? 419  TRP A C   1 
ATOM   1030 O  O   . TRP A 1 156 ? -35.129 -28.168 -3.077  0.50 68.80  ? 419  TRP A O   1 
ATOM   1031 C  CB  . TRP A 1 156 ? -37.191 -26.963 -5.122  0.50 64.27  ? 419  TRP A CB  1 
ATOM   1032 C  CG  . TRP A 1 156 ? -38.040 -25.801 -5.535  0.50 59.12  ? 419  TRP A CG  1 
ATOM   1033 C  CD1 . TRP A 1 156 ? -39.389 -25.795 -5.736  0.50 58.57  ? 419  TRP A CD1 1 
ATOM   1034 C  CD2 . TRP A 1 156 ? -37.590 -24.460 -5.801  0.50 56.95  ? 419  TRP A CD2 1 
ATOM   1035 N  NE1 . TRP A 1 156 ? -39.811 -24.545 -6.103  0.50 57.25  ? 419  TRP A NE1 1 
ATOM   1036 C  CE2 . TRP A 1 156 ? -38.729 -23.705 -6.154  0.50 54.50  ? 419  TRP A CE2 1 
ATOM   1037 C  CE3 . TRP A 1 156 ? -36.343 -23.826 -5.778  0.50 56.22  ? 419  TRP A CE3 1 
ATOM   1038 C  CZ2 . TRP A 1 156 ? -38.654 -22.351 -6.473  0.50 55.54  ? 419  TRP A CZ2 1 
ATOM   1039 C  CZ3 . TRP A 1 156 ? -36.269 -22.489 -6.096  0.50 54.84  ? 419  TRP A CZ3 1 
ATOM   1040 C  CH2 . TRP A 1 156 ? -37.410 -21.763 -6.437  0.50 56.29  ? 419  TRP A CH2 1 
ATOM   1041 N  N   . LYS A 1 157 ? -36.821 -29.701 -3.220  0.50 73.43  ? 420  LYS A N   1 
ATOM   1042 C  CA  . LYS A 1 157 ? -35.998 -30.908 -2.943  0.50 77.11  ? 420  LYS A CA  1 
ATOM   1043 C  C   . LYS A 1 157 ? -35.166 -31.230 -4.189  0.50 79.11  ? 420  LYS A C   1 
ATOM   1044 O  O   . LYS A 1 157 ? -34.094 -30.615 -4.364  0.50 81.85  ? 420  LYS A O   1 
ATOM   1045 C  CB  . LYS A 1 157 ? -36.889 -32.092 -2.558  0.50 77.58  ? 420  LYS A CB  1 
ATOM   1046 C  CG  . LYS A 1 157 ? -36.139 -33.352 -2.145  0.50 78.00  ? 420  LYS A CG  1 
ATOM   1047 C  CD  . LYS A 1 157 ? -36.994 -34.600 -2.190  0.50 77.75  ? 420  LYS A CD  1 
ATOM   1048 C  CE  . LYS A 1 157 ? -38.265 -34.477 -1.377  0.50 74.90  ? 420  LYS A CE  1 
ATOM   1049 N  NZ  . LYS A 1 157 ? -39.197 -35.596 -1.650  0.50 74.88  ? 420  LYS A NZ  1 
ATOM   1050 N  N   . SER A 1 158 ? -35.664 -32.149 -5.022  0.50 77.61  ? 421  SER A N   1 
ATOM   1051 C  CA  . SER A 1 158 ? -35.030 -32.603 -6.286  0.50 75.39  ? 421  SER A CA  1 
ATOM   1052 C  C   . SER A 1 158 ? -35.175 -31.519 -7.358  0.50 74.14  ? 421  SER A C   1 
ATOM   1053 O  O   . SER A 1 158 ? -35.951 -30.566 -7.141  0.50 70.95  ? 421  SER A O   1 
ATOM   1054 C  CB  . SER A 1 158 ? -35.631 -33.905 -6.741  0.50 74.37  ? 421  SER A CB  1 
ATOM   1055 O  OG  . SER A 1 158 ? -37.048 -33.823 -6.764  0.50 77.03  ? 421  SER A OG  1 
ATOM   1056 N  N   . ALA A 1 159 ? -34.453 -31.672 -8.472  0.50 72.57  ? 422  ALA A N   1 
ATOM   1057 C  CA  . ALA A 1 159 ? -34.483 -30.761 -9.639  0.50 69.90  ? 422  ALA A CA  1 
ATOM   1058 C  C   . ALA A 1 159 ? -35.888 -30.766 -10.251 0.50 66.50  ? 422  ALA A C   1 
ATOM   1059 O  O   . ALA A 1 159 ? -36.346 -29.701 -10.698 0.50 60.55  ? 422  ALA A O   1 
ATOM   1060 C  CB  . ALA A 1 159 ? -33.440 -31.185 -10.643 0.50 71.04  ? 422  ALA A CB  1 
ATOM   1061 N  N   . ARG A 1 160 ? -36.546 -31.927 -10.250 0.50 66.88  ? 423  ARG A N   1 
ATOM   1062 C  CA  . ARG A 1 160 ? -37.889 -32.132 -10.852 0.50 67.95  ? 423  ARG A CA  1 
ATOM   1063 C  C   . ARG A 1 160 ? -38.909 -31.200 -10.180 0.50 67.66  ? 423  ARG A C   1 
ATOM   1064 O  O   . ARG A 1 160 ? -39.895 -30.833 -10.851 0.50 63.80  ? 423  ARG A O   1 
ATOM   1065 C  CB  . ARG A 1 160 ? -38.287 -33.607 -10.738 0.50 70.49  ? 423  ARG A CB  1 
ATOM   1066 C  CG  . ARG A 1 160 ? -37.207 -34.569 -11.214 0.50 74.85  ? 423  ARG A CG  1 
ATOM   1067 C  CD  . ARG A 1 160 ? -37.674 -36.011 -11.307 0.50 76.30  ? 423  ARG A CD  1 
ATOM   1068 N  NE  . ARG A 1 160 ? -36.638 -36.876 -11.860 0.50 77.42  ? 423  ARG A NE  1 
ATOM   1069 C  CZ  . ARG A 1 160 ? -36.852 -38.094 -12.344 0.50 78.07  ? 423  ARG A CZ  1 
ATOM   1070 N  NH1 . ARG A 1 160 ? -35.845 -38.800 -12.831 0.50 76.76  ? 423  ARG A NH1 1 
ATOM   1071 N  NH2 . ARG A 1 160 ? -38.072 -38.600 -12.344 0.50 79.31  ? 423  ARG A NH2 1 
ATOM   1072 N  N   . GLU A 1 161 ? -38.678 -30.821 -8.915  0.50 65.78  ? 424  GLU A N   1 
ATOM   1073 C  CA  . GLU A 1 161 ? -39.594 -29.956 -8.115  0.50 63.27  ? 424  GLU A CA  1 
ATOM   1074 C  C   . GLU A 1 161 ? -39.525 -28.511 -8.628  0.50 60.19  ? 424  GLU A C   1 
ATOM   1075 O  O   . GLU A 1 161 ? -40.592 -27.881 -8.769  0.50 56.34  ? 424  GLU A O   1 
ATOM   1076 C  CB  . GLU A 1 161 ? -39.244 -30.011 -6.625  0.50 65.02  ? 424  GLU A CB  1 
ATOM   1077 C  CG  . GLU A 1 161 ? -39.778 -31.247 -5.918  0.50 66.60  ? 424  GLU A CG  1 
ATOM   1078 C  CD  . GLU A 1 161 ? -39.746 -31.187 -4.399  0.50 67.68  ? 424  GLU A CD  1 
ATOM   1079 O  OE1 . GLU A 1 161 ? -38.958 -30.388 -3.850  0.50 65.71  ? 424  GLU A OE1 1 
ATOM   1080 O  OE2 . GLU A 1 161 ? -40.515 -31.943 -3.768  0.50 68.48  ? 424  GLU A OE2 1 
ATOM   1081 N  N   . ALA A 1 162 ? -38.314 -28.011 -8.891  0.50 57.14  ? 425  ALA A N   1 
ATOM   1082 C  CA  . ALA A 1 162 ? -38.046 -26.619 -9.323  0.50 56.80  ? 425  ALA A CA  1 
ATOM   1083 C  C   . ALA A 1 162 ? -38.736 -26.334 -10.665 0.50 56.52  ? 425  ALA A C   1 
ATOM   1084 O  O   . ALA A 1 162 ? -39.428 -25.296 -10.770 0.50 52.47  ? 425  ALA A O   1 
ATOM   1085 C  CB  . ALA A 1 162 ? -36.556 -26.390 -9.409  0.50 55.08  ? 425  ALA A CB  1 
ATOM   1086 N  N   . VAL A 1 163 ? -38.549 -27.220 -11.648 0.50 57.82  ? 426  VAL A N   1 
ATOM   1087 C  CA  . VAL A 1 163 ? -38.971 -27.017 -13.067 0.50 60.59  ? 426  VAL A CA  1 
ATOM   1088 C  C   . VAL A 1 163 ? -40.492 -27.173 -13.168 0.50 64.40  ? 426  VAL A C   1 
ATOM   1089 O  O   . VAL A 1 163 ? -41.059 -26.775 -14.203 0.50 64.99  ? 426  VAL A O   1 
ATOM   1090 C  CB  . VAL A 1 163 ? -38.244 -27.993 -14.014 0.50 60.55  ? 426  VAL A CB  1 
ATOM   1091 C  CG1 . VAL A 1 163 ? -36.734 -27.815 -13.951 0.50 60.60  ? 426  VAL A CG1 1 
ATOM   1092 C  CG2 . VAL A 1 163 ? -38.628 -29.440 -13.742 0.50 58.69  ? 426  VAL A CG2 1 
ATOM   1093 N  N   . GLU A 1 164 ? -41.121 -27.734 -12.132 0.50 69.19  ? 427  GLU A N   1 
ATOM   1094 C  CA  . GLU A 1 164 ? -42.592 -27.947 -12.057 0.50 72.12  ? 427  GLU A CA  1 
ATOM   1095 C  C   . GLU A 1 164 ? -43.207 -26.875 -11.150 0.50 72.26  ? 427  GLU A C   1 
ATOM   1096 O  O   . GLU A 1 164 ? -44.346 -27.077 -10.686 0.50 74.71  ? 427  GLU A O   1 
ATOM   1097 C  CB  . GLU A 1 164 ? -42.893 -29.362 -11.558 0.50 71.90  ? 427  GLU A CB  1 
ATOM   1098 C  CG  . GLU A 1 164 ? -42.244 -30.445 -12.403 0.50 73.16  ? 427  GLU A CG  1 
ATOM   1099 C  CD  . GLU A 1 164 ? -42.509 -31.868 -11.942 0.50 76.07  ? 427  GLU A CD  1 
ATOM   1100 O  OE1 . GLU A 1 164 ? -43.396 -32.054 -11.086 0.50 77.30  ? 427  GLU A OE1 1 
ATOM   1101 O  OE2 . GLU A 1 164 ? -41.825 -32.788 -12.441 0.50 76.27  ? 427  GLU A OE2 1 
ATOM   1102 N  N   . ASP A 1 165 ? -42.479 -25.773 -10.933 0.50 72.18  ? 428  ASP A N   1 
ATOM   1103 C  CA  . ASP A 1 165 ? -42.857 -24.661 -10.018 0.50 73.14  ? 428  ASP A CA  1 
ATOM   1104 C  C   . ASP A 1 165 ? -42.548 -23.315 -10.685 0.50 72.67  ? 428  ASP A C   1 
ATOM   1105 O  O   . ASP A 1 165 ? -41.358 -22.930 -10.725 0.50 67.90  ? 428  ASP A O   1 
ATOM   1106 C  CB  . ASP A 1 165 ? -42.125 -24.779 -8.678  0.50 74.50  ? 428  ASP A CB  1 
ATOM   1107 C  CG  . ASP A 1 165 ? -42.196 -23.523 -7.824  0.50 75.43  ? 428  ASP A CG  1 
ATOM   1108 O  OD1 . ASP A 1 165 ? -42.570 -22.462 -8.367  0.50 73.64  ? 428  ASP A OD1 1 
ATOM   1109 O  OD2 . ASP A 1 165 ? -41.873 -23.616 -6.621  0.50 77.48  ? 428  ASP A OD2 1 
ATOM   1110 N  N   . SER A 1 166 ? -43.590 -22.625 -11.162 0.50 72.40  ? 429  SER A N   1 
ATOM   1111 C  CA  . SER A 1 166 ? -43.514 -21.327 -11.883 0.50 71.50  ? 429  SER A CA  1 
ATOM   1112 C  C   . SER A 1 166 ? -42.760 -20.294 -11.038 0.50 70.23  ? 429  SER A C   1 
ATOM   1113 O  O   . SER A 1 166 ? -42.369 -19.248 -11.596 0.50 69.63  ? 429  SER A O   1 
ATOM   1114 C  CB  . SER A 1 166 ? -44.894 -20.840 -12.243 0.50 77.03  ? 429  SER A CB  1 
ATOM   1115 O  OG  . SER A 1 166 ? -45.626 -21.853 -12.922 0.50 80.50  ? 429  SER A OG  1 
ATOM   1116 N  N   . GLY A 1 167 ? -42.576 -20.574 -9.743  0.50 70.57  ? 430  GLY A N   1 
ATOM   1117 C  CA  . GLY A 1 167 ? -41.842 -19.701 -8.804  0.50 69.35  ? 430  GLY A CA  1 
ATOM   1118 C  C   . GLY A 1 167 ? -40.366 -19.649 -9.154  0.50 68.52  ? 430  GLY A C   1 
ATOM   1119 O  O   . GLY A 1 167 ? -39.812 -18.538 -9.234  0.50 66.07  ? 430  GLY A O   1 
ATOM   1120 N  N   . PHE A 1 168 ? -39.767 -20.822 -9.371  0.50 68.20  ? 431  PHE A N   1 
ATOM   1121 C  CA  . PHE A 1 168 ? -38.372 -21.014 -9.847  0.50 68.46  ? 431  PHE A CA  1 
ATOM   1122 C  C   . PHE A 1 168 ? -38.129 -20.164 -11.100 0.50 66.59  ? 431  PHE A C   1 
ATOM   1123 O  O   . PHE A 1 168 ? -37.172 -19.365 -11.104 0.50 66.21  ? 431  PHE A O   1 
ATOM   1124 C  CB  . PHE A 1 168 ? -38.114 -22.498 -10.122 0.50 71.01  ? 431  PHE A CB  1 
ATOM   1125 C  CG  . PHE A 1 168 ? -36.811 -22.797 -10.820 0.50 70.02  ? 431  PHE A CG  1 
ATOM   1126 C  CD1 . PHE A 1 168 ? -35.599 -22.491 -10.222 0.50 70.50  ? 431  PHE A CD1 1 
ATOM   1127 C  CD2 . PHE A 1 168 ? -36.798 -23.398 -12.069 0.50 72.80  ? 431  PHE A CD2 1 
ATOM   1128 C  CE1 . PHE A 1 168 ? -34.402 -22.768 -10.864 0.50 71.40  ? 431  PHE A CE1 1 
ATOM   1129 C  CE2 . PHE A 1 168 ? -35.601 -23.675 -12.710 0.50 72.86  ? 431  PHE A CE2 1 
ATOM   1130 C  CZ  . PHE A 1 168 ? -34.405 -23.360 -12.106 0.50 73.92  ? 431  PHE A CZ  1 
ATOM   1131 N  N   . TRP A 1 169 ? -38.973 -20.326 -12.127 1.00 67.59  ? 432  TRP A N   1 
ATOM   1132 C  CA  . TRP A 1 169 ? -38.785 -19.638 -13.438 1.00 61.22  ? 432  TRP A CA  1 
ATOM   1133 C  C   . TRP A 1 169 ? -38.762 -18.101 -13.280 1.00 65.94  ? 432  TRP A C   1 
ATOM   1134 O  O   . TRP A 1 169 ? -38.031 -17.421 -14.055 1.00 62.19  ? 432  TRP A O   1 
ATOM   1135 C  CB  . TRP A 1 169 ? -39.769 -20.167 -14.485 1.00 56.64  ? 432  TRP A CB  1 
ATOM   1136 C  CG  . TRP A 1 169 ? -39.572 -21.629 -14.747 1.00 58.60  ? 432  TRP A CG  1 
ATOM   1137 C  CD1 . TRP A 1 169 ? -40.385 -22.639 -14.330 1.00 60.82  ? 432  TRP A CD1 1 
ATOM   1138 C  CD2 . TRP A 1 169 ? -38.467 -22.275 -15.424 1.00 60.10  ? 432  TRP A CD2 1 
ATOM   1139 N  NE1 . TRP A 1 169 ? -39.892 -23.854 -14.722 1.00 60.75  ? 432  TRP A NE1 1 
ATOM   1140 C  CE2 . TRP A 1 169 ? -38.711 -23.666 -15.390 1.00 57.95  ? 432  TRP A CE2 1 
ATOM   1141 C  CE3 . TRP A 1 169 ? -37.313 -21.824 -16.073 1.00 61.77  ? 432  TRP A CE3 1 
ATOM   1142 C  CZ2 . TRP A 1 169 ? -37.846 -24.601 -15.958 1.00 57.20  ? 432  TRP A CZ2 1 
ATOM   1143 C  CZ3 . TRP A 1 169 ? -36.462 -22.749 -16.648 1.00 61.02  ? 432  TRP A CZ3 1 
ATOM   1144 C  CH2 . TRP A 1 169 ? -36.722 -24.117 -16.585 1.00 56.43  ? 432  TRP A CH2 1 
ATOM   1145 N  N   . GLU A 1 170 ? -39.482 -17.542 -12.297 0.50 62.87  ? 433  GLU A N   1 
ATOM   1146 C  CA  . GLU A 1 170 ? -39.444 -16.080 -12.002 0.50 61.22  ? 433  GLU A CA  1 
ATOM   1147 C  C   . GLU A 1 170 ? -38.046 -15.720 -11.491 0.50 59.63  ? 433  GLU A C   1 
ATOM   1148 O  O   . GLU A 1 170 ? -37.517 -14.662 -11.891 0.50 60.43  ? 433  GLU A O   1 
ATOM   1149 C  CB  . GLU A 1 170 ? -40.532 -15.669 -11.003 0.50 59.50  ? 433  GLU A CB  1 
ATOM   1150 C  CG  . GLU A 1 170 ? -41.776 -15.112 -11.672 0.50 57.81  ? 433  GLU A CG  1 
ATOM   1151 C  CD  . GLU A 1 170 ? -42.890 -14.681 -10.730 0.50 57.47  ? 433  GLU A CD  1 
ATOM   1152 O  OE1 . GLU A 1 170 ? -42.600 -13.926 -9.779  0.50 56.36  ? 433  GLU A OE1 1 
ATOM   1153 O  OE2 . GLU A 1 170 ? -44.045 -15.109 -10.947 0.50 53.94  ? 433  GLU A OE2 1 
ATOM   1154 N  N   . LEU A 1 171 ? -37.465 -16.581 -10.652 0.50 62.60  ? 434  LEU A N   1 
ATOM   1155 C  CA  . LEU A 1 171 ? -36.054 -16.468 -10.195 0.50 63.57  ? 434  LEU A CA  1 
ATOM   1156 C  C   . LEU A 1 171 ? -35.141 -16.461 -11.429 0.50 61.30  ? 434  LEU A C   1 
ATOM   1157 O  O   . LEU A 1 171 ? -34.270 -15.567 -11.518 0.50 58.78  ? 434  LEU A O   1 
ATOM   1158 C  CB  . LEU A 1 171 ? -35.737 -17.638 -9.257  0.50 64.66  ? 434  LEU A CB  1 
ATOM   1159 C  CG  . LEU A 1 171 ? -36.693 -17.803 -8.074  0.50 66.57  ? 434  LEU A CG  1 
ATOM   1160 C  CD1 . LEU A 1 171 ? -36.165 -18.829 -7.082  0.50 66.55  ? 434  LEU A CD1 1 
ATOM   1161 C  CD2 . LEU A 1 171 ? -36.935 -16.468 -7.382  0.50 66.55  ? 434  LEU A CD2 1 
ATOM   1162 N  N   . VAL A 1 172 ? -35.363 -17.410 -12.348 1.00 61.96  ? 435  VAL A N   1 
ATOM   1163 C  CA  . VAL A 1 172 ? -34.595 -17.547 -13.631 1.00 58.18  ? 435  VAL A CA  1 
ATOM   1164 C  C   . VAL A 1 172 ? -34.766 -16.265 -14.449 1.00 54.73  ? 435  VAL A C   1 
ATOM   1165 O  O   . VAL A 1 172 ? -33.742 -15.648 -14.836 1.00 56.09  ? 435  VAL A O   1 
ATOM   1166 C  CB  . VAL A 1 172 ? -35.062 -18.789 -14.424 1.00 63.33  ? 435  VAL A CB  1 
ATOM   1167 C  CG1 . VAL A 1 172 ? -34.386 -18.875 -15.785 1.00 65.96  ? 435  VAL A CG1 1 
ATOM   1168 C  CG2 . VAL A 1 172 ? -34.871 -20.096 -13.655 1.00 61.94  ? 435  VAL A CG2 1 
ATOM   1169 N  N   . ASP A 1 173 ? -36.019 -15.818 -14.627 1.00 63.10  ? 436  ASP A N   1 
ATOM   1170 C  CA  . ASP A 1 173 ? -36.349 -14.538 -15.316 1.00 60.87  ? 436  ASP A CA  1 
ATOM   1171 C  C   . ASP A 1 173 ? -35.561 -13.384 -14.684 1.00 56.11  ? 436  ASP A C   1 
ATOM   1172 O  O   . ASP A 1 173 ? -34.983 -12.564 -15.440 1.00 53.63  ? 436  ASP A O   1 
ATOM   1173 C  CB  . ASP A 1 173 ? -37.852 -14.238 -15.292 1.00 73.05  ? 436  ASP A CB  1 
ATOM   1174 C  CG  . ASP A 1 173 ? -38.701 -15.211 -16.094 1.00 74.66  ? 436  ASP A CG  1 
ATOM   1175 O  OD1 . ASP A 1 173 ? -38.266 -15.596 -17.206 1.00 75.87  ? 436  ASP A OD1 1 
ATOM   1176 O  OD2 . ASP A 1 173 ? -39.790 -15.586 -15.594 1.00 87.21  ? 436  ASP A OD2 1 
ATOM   1177 N  N   . LYS A 1 174 ? -35.532 -13.275 -13.357 1.00 59.64  ? 437  LYS A N   1 
ATOM   1178 C  CA  . LYS A 1 174 ? -34.872 -12.099 -12.727 1.00 63.68  ? 437  LYS A CA  1 
ATOM   1179 C  C   . LYS A 1 174 ? -33.401 -12.122 -13.148 1.00 61.95  ? 437  LYS A C   1 
ATOM   1180 O  O   . LYS A 1 174 ? -32.896 -11.084 -13.649 1.00 60.30  ? 437  LYS A O   1 
ATOM   1181 C  CB  . LYS A 1 174 ? -35.026 -12.080 -11.203 1.00 65.78  ? 437  LYS A CB  1 
ATOM   1182 C  CG  . LYS A 1 174 ? -34.420 -10.850 -10.537 1.00 74.29  ? 437  LYS A CG  1 
ATOM   1183 C  CD  . LYS A 1 174 ? -34.500 -10.828 -9.013  1.00 74.46  ? 437  LYS A CD  1 
ATOM   1184 C  CE  . LYS A 1 174 ? -33.715 -9.671  -8.427  1.00 78.90  ? 437  LYS A CE  1 
ATOM   1185 N  NZ  . LYS A 1 174 ? -33.831 -9.613  -6.951  1.00 85.58  ? 437  LYS A NZ  1 
ATOM   1186 N  N   . GLU A 1 175 ? -32.750 -13.278 -12.989 1.00 61.92  ? 438  GLU A N   1 
ATOM   1187 C  CA  . GLU A 1 175 ? -31.314 -13.453 -13.333 1.00 59.50  ? 438  GLU A CA  1 
ATOM   1188 C  C   . GLU A 1 175 ? -31.116 -13.138 -14.815 1.00 47.48  ? 438  GLU A C   1 
ATOM   1189 O  O   . GLU A 1 175 ? -30.155 -12.422 -15.147 1.00 56.88  ? 438  GLU A O   1 
ATOM   1190 C  CB  . GLU A 1 175 ? -30.855 -14.883 -13.069 1.00 64.28  ? 438  GLU A CB  1 
ATOM   1191 C  CG  . GLU A 1 175 ? -30.093 -15.039 -11.783 1.00 72.85  ? 438  GLU A CG  1 
ATOM   1192 C  CD  . GLU A 1 175 ? -28.812 -14.235 -11.750 1.00 65.33  ? 438  GLU A CD  1 
ATOM   1193 O  OE1 . GLU A 1 175 ? -27.793 -14.724 -12.259 1.00 74.28  ? 438  GLU A OE1 1 
ATOM   1194 O  OE2 . GLU A 1 175 ? -28.851 -13.124 -11.231 1.00 67.46  ? 438  GLU A OE2 1 
ATOM   1195 N  N   . ARG A 1 176 ? -32.006 -13.679 -15.653 1.00 53.30  ? 439  ARG A N   1 
ATOM   1196 C  CA  . ARG A 1 176 ? -31.948 -13.580 -17.133 1.00 51.75  ? 439  ARG A CA  1 
ATOM   1197 C  C   . ARG A 1 176 ? -31.977 -12.110 -17.541 1.00 57.16  ? 439  ARG A C   1 
ATOM   1198 O  O   . ARG A 1 176 ? -31.078 -11.691 -18.296 1.00 56.49  ? 439  ARG A O   1 
ATOM   1199 C  CB  . ARG A 1 176 ? -33.105 -14.376 -17.722 1.00 54.05  ? 439  ARG A CB  1 
ATOM   1200 C  CG  . ARG A 1 176 ? -33.031 -14.522 -19.231 1.00 56.29  ? 439  ARG A CG  1 
ATOM   1201 C  CD  . ARG A 1 176 ? -33.832 -15.744 -19.611 1.00 50.74  ? 439  ARG A CD  1 
ATOM   1202 N  NE  . ARG A 1 176 ? -33.983 -15.754 -21.038 1.00 59.16  ? 439  ARG A NE  1 
ATOM   1203 C  CZ  . ARG A 1 176 ? -34.739 -16.601 -21.704 1.00 74.08  ? 439  ARG A CZ  1 
ATOM   1204 N  NH1 . ARG A 1 176 ? -35.378 -17.563 -21.048 1.00 73.86  ? 439  ARG A NH1 1 
ATOM   1205 N  NH2 . ARG A 1 176 ? -34.822 -16.488 -23.025 1.00 73.02  ? 439  ARG A NH2 1 
ATOM   1206 N  N   . ASN A 1 177 ? -32.932 -11.330 -17.015 1.00 60.10  ? 440  ASN A N   1 
ATOM   1207 C  CA  . ASN A 1 177 ? -33.032 -9.876  -17.321 1.00 57.79  ? 440  ASN A CA  1 
ATOM   1208 C  C   . ASN A 1 177 ? -31.782 -9.169  -16.793 1.00 57.48  ? 440  ASN A C   1 
ATOM   1209 O  O   . ASN A 1 177 ? -31.258 -8.312  -17.519 1.00 59.12  ? 440  ASN A O   1 
ATOM   1210 C  CB  . ASN A 1 177 ? -34.365 -9.293  -16.840 1.00 63.55  ? 440  ASN A CB  1 
ATOM   1211 C  CG  . ASN A 1 177 ? -35.495 -9.752  -17.738 1.00 63.01  ? 440  ASN A CG  1 
ATOM   1212 O  OD1 . ASN A 1 177 ? -35.633 -9.281  -18.864 1.00 76.78  ? 440  ASN A OD1 1 
ATOM   1213 N  ND2 . ASN A 1 177 ? -36.266 -10.720 -17.288 1.00 63.48  ? 440  ASN A ND2 1 
ATOM   1214 N  N   . LEU A 1 178 ? -31.262 -9.582  -15.631 1.00 63.55  ? 441  LEU A N   1 
ATOM   1215 C  CA  . LEU A 1 178 ? -29.966 -9.087  -15.083 1.00 66.76  ? 441  LEU A CA  1 
ATOM   1216 C  C   . LEU A 1 178 ? -28.814 -9.356  -16.075 1.00 67.69  ? 441  LEU A C   1 
ATOM   1217 O  O   . LEU A 1 178 ? -28.022 -8.414  -16.334 1.00 67.84  ? 441  LEU A O   1 
ATOM   1218 C  CB  . LEU A 1 178 ? -29.711 -9.725  -13.709 1.00 75.65  ? 441  LEU A CB  1 
ATOM   1219 C  CG  . LEU A 1 178 ? -30.548 -9.169  -12.550 1.00 80.79  ? 441  LEU A CG  1 
ATOM   1220 C  CD1 . LEU A 1 178 ? -30.356 -9.986  -11.271 1.00 79.56  ? 441  LEU A CD1 1 
ATOM   1221 C  CD2 . LEU A 1 178 ? -30.217 -7.703  -12.290 1.00 83.35  ? 441  LEU A CD2 1 
ATOM   1222 N  N   . HIS A 1 179 ? -28.703 -10.562 -16.642 1.00 63.71  ? 442  HIS A N   1 
ATOM   1223 C  CA  . HIS A 1 179 ? -27.633 -10.890 -17.632 1.00 64.73  ? 442  HIS A CA  1 
ATOM   1224 C  C   . HIS A 1 179 ? -27.741 -9.966  -18.867 1.00 63.62  ? 442  HIS A C   1 
ATOM   1225 O  O   . HIS A 1 179 ? -26.692 -9.404  -19.277 1.00 64.25  ? 442  HIS A O   1 
ATOM   1226 C  CB  . HIS A 1 179 ? -27.630 -12.388 -17.993 1.00 60.68  ? 442  HIS A CB  1 
ATOM   1227 C  CG  . HIS A 1 179 ? -27.124 -13.295 -16.913 1.00 58.21  ? 442  HIS A CG  1 
ATOM   1228 N  ND1 . HIS A 1 179 ? -27.187 -14.671 -17.020 1.00 56.39  ? 442  HIS A ND1 1 
ATOM   1229 C  CD2 . HIS A 1 179 ? -26.566 -13.032 -15.710 1.00 53.38  ? 442  HIS A CD2 1 
ATOM   1230 C  CE1 . HIS A 1 179 ? -26.706 -15.209 -15.918 1.00 60.24  ? 442  HIS A CE1 1 
ATOM   1231 N  NE2 . HIS A 1 179 ? -26.317 -14.220 -15.099 1.00 54.00  ? 442  HIS A NE2 1 
ATOM   1232 N  N   . LEU A 1 180 ? -28.952 -9.744  -19.403 1.00 70.53  ? 443  LEU A N   1 
ATOM   1233 C  CA  . LEU A 1 180 ? -29.207 -8.780  -20.525 1.00 68.61  ? 443  LEU A CA  1 
ATOM   1234 C  C   . LEU A 1 180 ? -28.726 -7.372  -20.127 1.00 68.26  ? 443  LEU A C   1 
ATOM   1235 O  O   . LEU A 1 180 ? -28.232 -6.635  -20.983 1.00 65.43  ? 443  LEU A O   1 
ATOM   1236 C  CB  . LEU A 1 180 ? -30.692 -8.801  -20.912 1.00 69.75  ? 443  LEU A CB  1 
ATOM   1237 C  CG  . LEU A 1 180 ? -31.265 -10.155 -21.358 1.00 68.29  ? 443  LEU A CG  1 
ATOM   1238 C  CD1 . LEU A 1 180 ? -32.785 -10.137 -21.354 1.00 70.94  ? 443  LEU A CD1 1 
ATOM   1239 C  CD2 . LEU A 1 180 ? -30.772 -10.564 -22.735 1.00 67.00  ? 443  LEU A CD2 1 
ATOM   1240 N  N   . GLU A 1 181 ? -28.869 -7.041  -18.839 0.50 72.48  ? 444  GLU A N   1 
ATOM   1241 C  CA  . GLU A 1 181 ? -28.408 -5.779  -18.197 0.50 76.68  ? 444  GLU A CA  1 
ATOM   1242 C  C   . GLU A 1 181 ? -26.876 -5.782  -18.060 0.50 75.95  ? 444  GLU A C   1 
ATOM   1243 O  O   . GLU A 1 181 ? -26.319 -4.727  -17.691 0.50 74.24  ? 444  GLU A O   1 
ATOM   1244 C  CB  . GLU A 1 181 ? -29.073 -5.656  -16.824 0.50 79.96  ? 444  GLU A CB  1 
ATOM   1245 C  CG  . GLU A 1 181 ? -29.568 -4.264  -16.470 0.50 81.23  ? 444  GLU A CG  1 
ATOM   1246 C  CD  . GLU A 1 181 ? -30.374 -4.217  -15.178 0.50 81.76  ? 444  GLU A CD  1 
ATOM   1247 O  OE1 . GLU A 1 181 ? -30.064 -3.367  -14.313 0.50 81.99  ? 444  GLU A OE1 1 
ATOM   1248 O  OE2 . GLU A 1 181 ? -31.308 -5.037  -15.033 0.50 77.56  ? 444  GLU A OE2 1 
ATOM   1249 N  N   . GLY A 1 182 ? -26.225 -6.920  -18.336 1.00 76.58  ? 445  GLY A N   1 
ATOM   1250 C  CA  . GLY A 1 182 ? -24.760 -7.086  -18.191 1.00 69.92  ? 445  GLY A CA  1 
ATOM   1251 C  C   . GLY A 1 182 ? -24.313 -7.336  -16.753 1.00 60.83  ? 445  GLY A C   1 
ATOM   1252 O  O   . GLY A 1 182 ? -23.126 -7.139  -16.475 1.00 70.49  ? 445  GLY A O   1 
ATOM   1253 N  N   . LYS A 1 183 ? -25.214 -7.763  -15.869 1.00 56.54  ? 446  LYS A N   1 
ATOM   1254 C  CA  . LYS A 1 183 ? -24.960 -7.958  -14.413 1.00 60.23  ? 446  LYS A CA  1 
ATOM   1255 C  C   . LYS A 1 183 ? -25.384 -9.373  -13.988 1.00 49.49  ? 446  LYS A C   1 
ATOM   1256 O  O   . LYS A 1 183 ? -26.209 -9.966  -14.690 1.00 51.24  ? 446  LYS A O   1 
ATOM   1257 C  CB  . LYS A 1 183 ? -25.774 -6.953  -13.583 1.00 71.18  ? 446  LYS A CB  1 
ATOM   1258 C  CG  . LYS A 1 183 ? -25.592 -5.482  -13.946 1.00 74.43  ? 446  LYS A CG  1 
ATOM   1259 C  CD  . LYS A 1 183 ? -26.846 -4.662  -13.728 1.00 79.25  ? 446  LYS A CD  1 
ATOM   1260 C  CE  . LYS A 1 183 ? -26.699 -3.217  -14.159 1.00 84.03  ? 446  LYS A CE  1 
ATOM   1261 N  NZ  . LYS A 1 183 ? -26.486 -2.330  -12.992 1.00 85.54  ? 446  LYS A NZ  1 
ATOM   1262 N  N   . CYS A 1 184 ? -24.911 -9.850  -12.827 1.00 55.84  ? 447  CYS A N   1 
ATOM   1263 C  CA  . CYS A 1 184 ? -25.156 -11.220 -12.277 1.00 54.38  ? 447  CYS A CA  1 
ATOM   1264 C  C   . CYS A 1 184 ? -25.393 -11.130 -10.759 1.00 54.46  ? 447  CYS A C   1 
ATOM   1265 O  O   . CYS A 1 184 ? -24.655 -10.371 -10.099 1.00 60.98  ? 447  CYS A O   1 
ATOM   1266 C  CB  . CYS A 1 184 ? -23.954 -12.125 -12.586 1.00 55.24  ? 447  CYS A CB  1 
ATOM   1267 S  SG  . CYS A 1 184 ? -24.193 -13.877 -12.174 1.00 51.57  ? 447  CYS A SG  1 
ATOM   1268 N  N   . GLU A 1 185 ? -26.310 -11.927 -10.201 1.00 56.51  ? 448  GLU A N   1 
ATOM   1269 C  CA  . GLU A 1 185 ? -26.623 -11.901 -8.747  1.00 61.18  ? 448  GLU A CA  1 
ATOM   1270 C  C   . GLU A 1 185 ? -26.464 -13.279 -8.090  1.00 61.81  ? 448  GLU A C   1 
ATOM   1271 O  O   . GLU A 1 185 ? -26.100 -13.313 -6.899  1.00 63.73  ? 448  GLU A O   1 
ATOM   1272 C  CB  . GLU A 1 185 ? -28.041 -11.366 -8.518  1.00 71.77  ? 448  GLU A CB  1 
ATOM   1273 C  CG  . GLU A 1 185 ? -28.316 -10.987 -7.072  1.00 75.36  ? 448  GLU A CG  1 
ATOM   1274 C  CD  . GLU A 1 185 ? -29.746 -10.582 -6.761  1.00 81.14  ? 448  GLU A CD  1 
ATOM   1275 O  OE1 . GLU A 1 185 ? -29.975 -9.370  -6.581  1.00 87.00  ? 448  GLU A OE1 1 
ATOM   1276 O  OE2 . GLU A 1 185 ? -30.625 -11.480 -6.687  1.00 83.65  ? 448  GLU A OE2 1 
ATOM   1277 N  N   . THR A 1 186 ? -26.749 -14.372 -8.795  1.00 57.55  ? 449  THR A N   1 
ATOM   1278 C  CA  . THR A 1 186 ? -26.967 -15.696 -8.167  1.00 55.65  ? 449  THR A CA  1 
ATOM   1279 C  C   . THR A 1 186 ? -26.139 -16.802 -8.834  1.00 52.78  ? 449  THR A C   1 
ATOM   1280 O  O   . THR A 1 186 ? -26.274 -17.938 -8.370  1.00 56.96  ? 449  THR A O   1 
ATOM   1281 C  CB  . THR A 1 186 ? -28.460 -16.033 -8.203  1.00 62.76  ? 449  THR A CB  1 
ATOM   1282 O  OG1 . THR A 1 186 ? -28.851 -16.112 -9.571  1.00 64.59  ? 449  THR A OG1 1 
ATOM   1283 C  CG2 . THR A 1 186 ? -29.312 -14.995 -7.513  1.00 67.58  ? 449  THR A CG2 1 
ATOM   1284 N  N   . CYS A 1 187 ? -25.337 -16.500 -9.865  1.00 51.47  ? 450  CYS A N   1 
ATOM   1285 C  CA  . CYS A 1 187 ? -24.493 -17.496 -10.590 1.00 48.79  ? 450  CYS A CA  1 
ATOM   1286 C  C   . CYS A 1 187 ? -23.152 -17.675 -9.841  1.00 48.70  ? 450  CYS A C   1 
ATOM   1287 O  O   . CYS A 1 187 ? -22.117 -17.066 -10.228 1.00 47.70  ? 450  CYS A O   1 
ATOM   1288 C  CB  . CYS A 1 187 ? -24.386 -17.104 -12.056 1.00 46.81  ? 450  CYS A CB  1 
ATOM   1289 S  SG  . CYS A 1 187 ? -26.026 -16.914 -12.829 1.00 49.25  ? 450  CYS A SG  1 
ATOM   1290 N  N   . VAL A 1 188 ? -23.164 -18.500 -8.791  0.50 49.73  ? 451  VAL A N   1 
ATOM   1291 C  CA  . VAL A 1 188 ? -21.994 -18.753 -7.895  0.50 52.10  ? 451  VAL A CA  1 
ATOM   1292 C  C   . VAL A 1 188 ? -21.667 -20.251 -7.890  0.50 51.67  ? 451  VAL A C   1 
ATOM   1293 O  O   . VAL A 1 188 ? -22.591 -21.066 -7.726  0.50 49.05  ? 451  VAL A O   1 
ATOM   1294 C  CB  . VAL A 1 188 ? -22.265 -18.242 -6.467  0.50 53.06  ? 451  VAL A CB  1 
ATOM   1295 C  CG1 . VAL A 1 188 ? -21.190 -18.704 -5.490  0.50 53.57  ? 451  VAL A CG1 1 
ATOM   1296 C  CG2 . VAL A 1 188 ? -22.410 -16.730 -6.437  0.50 54.38  ? 451  VAL A CG2 1 
ATOM   1297 N  N   . TYR A 1 189 ? -20.385 -20.585 -8.040  0.50 54.30  ? 452  TYR A N   1 
ATOM   1298 C  CA  . TYR A 1 189 ? -19.871 -21.979 -8.087  0.50 56.84  ? 452  TYR A CA  1 
ATOM   1299 C  C   . TYR A 1 189 ? -19.720 -22.519 -6.658  0.50 59.32  ? 452  TYR A C   1 
ATOM   1300 O  O   . TYR A 1 189 ? -19.427 -21.723 -5.741  0.50 58.48  ? 452  TYR A O   1 
ATOM   1301 C  CB  . TYR A 1 189 ? -18.556 -22.024 -8.871  0.50 55.42  ? 452  TYR A CB  1 
ATOM   1302 C  CG  . TYR A 1 189 ? -18.687 -21.724 -10.343 0.50 54.17  ? 452  TYR A CG  1 
ATOM   1303 C  CD1 . TYR A 1 189 ? -19.399 -22.567 -11.181 0.50 55.73  ? 452  TYR A CD1 1 
ATOM   1304 C  CD2 . TYR A 1 189 ? -18.092 -20.607 -10.907 0.50 54.27  ? 452  TYR A CD2 1 
ATOM   1305 C  CE1 . TYR A 1 189 ? -19.525 -22.306 -12.535 0.50 54.70  ? 452  TYR A CE1 1 
ATOM   1306 C  CE2 . TYR A 1 189 ? -18.207 -20.331 -12.262 0.50 53.01  ? 452  TYR A CE2 1 
ATOM   1307 C  CZ  . TYR A 1 189 ? -18.928 -21.184 -13.078 0.50 53.98  ? 452  TYR A CZ  1 
ATOM   1308 O  OH  . TYR A 1 189 ? -19.052 -20.931 -14.413 0.50 54.05  ? 452  TYR A OH  1 
ATOM   1309 N  N   . ASN A 1 190 ? -19.946 -23.827 -6.481  1.00 64.50  ? 453  ASN A N   1 
ATOM   1310 C  CA  . ASN A 1 190 ? -19.704 -24.562 -5.205  1.00 67.31  ? 453  ASN A CA  1 
ATOM   1311 C  C   . ASN A 1 190 ? -18.715 -25.706 -5.463  1.00 67.22  ? 453  ASN A C   1 
ATOM   1312 O  O   . ASN A 1 190 ? -19.122 -26.674 -6.131  1.00 63.38  ? 453  ASN A O   1 
ATOM   1313 C  CB  . ASN A 1 190 ? -20.981 -25.211 -4.685  1.00 67.42  ? 453  ASN A CB  1 
ATOM   1314 C  CG  . ASN A 1 190 ? -21.998 -24.187 -4.264  1.00 67.43  ? 453  ASN A CG  1 
ATOM   1315 O  OD1 . ASN A 1 190 ? -21.935 -23.041 -4.683  1.00 75.17  ? 453  ASN A OD1 1 
ATOM   1316 N  ND2 . ASN A 1 190 ? -22.923 -24.591 -3.414  1.00 73.65  ? 453  ASN A ND2 1 
ATOM   1317 N  N   . MET A 1 191 ? -17.480 -25.605 -4.961  1.00 82.37  ? 454  MET A N   1 
ATOM   1318 C  CA  . MET A 1 191 ? -16.377 -26.567 -5.248  1.00 91.86  ? 454  MET A CA  1 
ATOM   1319 C  C   . MET A 1 191 ? -16.576 -27.813 -4.375  1.00 96.45  ? 454  MET A C   1 
ATOM   1320 O  O   . MET A 1 191 ? -16.982 -27.661 -3.216  1.00 96.72  ? 454  MET A O   1 
ATOM   1321 C  CB  . MET A 1 191 ? -15.022 -25.923 -4.932  1.00 98.16  ? 454  MET A CB  1 
ATOM   1322 C  CG  . MET A 1 191 ? -13.832 -26.612 -5.575  1.00 107.86 ? 454  MET A CG  1 
ATOM   1323 S  SD  . MET A 1 191 ? -12.286 -25.682 -5.344  1.00 117.39 ? 454  MET A SD  1 
ATOM   1324 C  CE  . MET A 1 191 ? -12.293 -24.675 -6.827  1.00 114.98 ? 454  MET A CE  1 
ATOM   1325 N  N   . MET A 1 192 ? -16.318 -29.000 -4.939  0.50 100.34 ? 455  MET A N   1 
ATOM   1326 C  CA  . MET A 1 192 ? -16.454 -30.325 -4.267  0.50 101.42 ? 455  MET A CA  1 
ATOM   1327 C  C   . MET A 1 192 ? -15.879 -31.421 -5.174  0.50 100.10 ? 455  MET A C   1 
ATOM   1328 O  O   . MET A 1 192 ? -14.949 -31.103 -5.943  0.50 98.30  ? 455  MET A O   1 
ATOM   1329 C  CB  . MET A 1 192 ? -17.921 -30.646 -3.956  0.50 100.99 ? 455  MET A CB  1 
ATOM   1330 C  CG  . MET A 1 192 ? -18.312 -30.393 -2.509  0.50 100.88 ? 455  MET A CG  1 
ATOM   1331 S  SD  . MET A 1 192 ? -20.104 -30.394 -2.240  0.50 100.94 ? 455  MET A SD  1 
ATOM   1332 C  CE  . MET A 1 192 ? -20.418 -32.154 -2.103  0.50 100.94 ? 455  MET A CE  1 
ATOM   1333 N  N   . ALA A 1 210 ? -12.240 -31.801 -9.807  0.50 86.81  ? 473  ALA A N   1 
ATOM   1334 C  CA  . ALA A 1 210 ? -12.761 -30.712 -8.947  0.50 85.84  ? 473  ALA A CA  1 
ATOM   1335 C  C   . ALA A 1 210 ? -14.058 -30.164 -9.552  0.50 83.69  ? 473  ALA A C   1 
ATOM   1336 O  O   . ALA A 1 210 ? -13.979 -29.224 -10.368 0.50 91.93  ? 473  ALA A O   1 
ATOM   1337 C  CB  . ALA A 1 210 ? -11.716 -29.633 -8.796  0.50 85.98  ? 473  ALA A CB  1 
ATOM   1338 N  N   . ILE A 1 211 ? -15.202 -30.736 -9.162  0.34 77.80  ? 474  ILE A N   1 
ATOM   1339 C  CA  . ILE A 1 211 ? -16.549 -30.418 -9.725  0.34 73.08  ? 474  ILE A CA  1 
ATOM   1340 C  C   . ILE A 1 211 ? -17.105 -29.169 -9.033  0.34 69.69  ? 474  ILE A C   1 
ATOM   1341 O  O   . ILE A 1 211 ? -17.140 -29.137 -7.787  0.34 68.52  ? 474  ILE A O   1 
ATOM   1342 C  CB  . ILE A 1 211 ? -17.509 -31.617 -9.582  0.34 72.54  ? 474  ILE A CB  1 
ATOM   1343 C  CG1 . ILE A 1 211 ? -16.893 -32.910 -10.124 0.34 73.49  ? 474  ILE A CG1 1 
ATOM   1344 C  CG2 . ILE A 1 211 ? -18.848 -31.314 -10.236 0.34 70.94  ? 474  ILE A CG2 1 
ATOM   1345 C  CD1 . ILE A 1 211 ? -15.738 -33.436 -9.301  0.34 72.30  ? 474  ILE A CD1 1 
ATOM   1346 N  N   . TRP A 1 212 ? -17.530 -28.183 -9.826  0.50 65.45  ? 475  TRP A N   1 
ATOM   1347 C  CA  . TRP A 1 212 ? -18.150 -26.919 -9.352  0.50 64.76  ? 475  TRP A CA  1 
ATOM   1348 C  C   . TRP A 1 212 ? -19.654 -26.966 -9.637  0.50 65.00  ? 475  TRP A C   1 
ATOM   1349 O  O   . TRP A 1 212 ? -20.042 -26.648 -10.775 0.50 69.11  ? 475  TRP A O   1 
ATOM   1350 C  CB  . TRP A 1 212 ? -17.484 -25.710 -10.021 0.50 62.38  ? 475  TRP A CB  1 
ATOM   1351 C  CG  . TRP A 1 212 ? -15.989 -25.687 -9.920  0.50 59.39  ? 475  TRP A CG  1 
ATOM   1352 C  CD1 . TRP A 1 212 ? -15.171 -26.700 -9.510  0.50 59.43  ? 475  TRP A CD1 1 
ATOM   1353 C  CD2 . TRP A 1 212 ? -15.122 -24.597 -10.280 0.50 58.59  ? 475  TRP A CD2 1 
ATOM   1354 N  NE1 . TRP A 1 212 ? -13.860 -26.310 -9.571  0.50 58.38  ? 475  TRP A NE1 1 
ATOM   1355 C  CE2 . TRP A 1 212 ? -13.798 -25.025 -10.042 0.50 58.29  ? 475  TRP A CE2 1 
ATOM   1356 C  CE3 . TRP A 1 212 ? -15.334 -23.303 -10.770 0.50 55.64  ? 475  TRP A CE3 1 
ATOM   1357 C  CZ2 . TRP A 1 212 ? -12.698 -24.204 -10.282 0.50 58.94  ? 475  TRP A CZ2 1 
ATOM   1358 C  CZ3 . TRP A 1 212 ? -14.246 -22.495 -11.010 0.50 57.29  ? 475  TRP A CZ3 1 
ATOM   1359 C  CH2 . TRP A 1 212 ? -12.946 -22.943 -10.773 0.50 58.28  ? 475  TRP A CH2 1 
ATOM   1360 N  N   . TYR A 1 213 ? -20.460 -27.371 -8.650  0.50 65.47  ? 476  TYR A N   1 
ATOM   1361 C  CA  . TYR A 1 213 ? -21.945 -27.374 -8.718  0.50 65.50  ? 476  TYR A CA  1 
ATOM   1362 C  C   . TYR A 1 213 ? -22.447 -25.925 -8.651  0.50 65.80  ? 476  TYR A C   1 
ATOM   1363 O  O   . TYR A 1 213 ? -21.747 -25.066 -8.081  0.50 62.76  ? 476  TYR A O   1 
ATOM   1364 C  CB  . TYR A 1 213 ? -22.541 -28.233 -7.598  0.50 66.96  ? 476  TYR A CB  1 
ATOM   1365 C  CG  . TYR A 1 213 ? -22.114 -29.681 -7.610  0.50 68.51  ? 476  TYR A CG  1 
ATOM   1366 C  CD1 . TYR A 1 213 ? -22.624 -30.574 -8.539  0.50 70.92  ? 476  TYR A CD1 1 
ATOM   1367 C  CD2 . TYR A 1 213 ? -21.200 -30.163 -6.688  0.50 70.46  ? 476  TYR A CD2 1 
ATOM   1368 C  CE1 . TYR A 1 213 ? -22.238 -31.906 -8.553  0.50 71.22  ? 476  TYR A CE1 1 
ATOM   1369 C  CE2 . TYR A 1 213 ? -20.804 -31.492 -6.686  0.50 70.95  ? 476  TYR A CE2 1 
ATOM   1370 C  CZ  . TYR A 1 213 ? -21.323 -32.367 -7.623  0.50 71.12  ? 476  TYR A CZ  1 
ATOM   1371 O  OH  . TYR A 1 213 ? -20.932 -33.677 -7.624  0.50 69.71  ? 476  TYR A OH  1 
ATOM   1372 N  N   . MET A 1 214 ? -23.616 -25.667 -9.245  1.00 68.27  ? 477  MET A N   1 
ATOM   1373 C  CA  . MET A 1 214 ? -24.291 -24.341 -9.233  1.00 65.31  ? 477  MET A CA  1 
ATOM   1374 C  C   . MET A 1 214 ? -25.740 -24.689 -8.955  1.00 55.82  ? 477  MET A C   1 
ATOM   1375 O  O   . MET A 1 214 ? -26.067 -25.843 -9.043  1.00 56.03  ? 477  MET A O   1 
ATOM   1376 C  CB  . MET A 1 214 ? -24.217 -23.672 -10.605 1.00 70.64  ? 477  MET A CB  1 
ATOM   1377 C  CG  . MET A 1 214 ? -23.198 -22.581 -10.751 1.00 73.91  ? 477  MET A CG  1 
ATOM   1378 S  SD  . MET A 1 214 ? -23.097 -22.114 -12.500 1.00 76.06  ? 477  MET A SD  1 
ATOM   1379 C  CE  . MET A 1 214 ? -22.369 -20.486 -12.299 1.00 68.35  ? 477  MET A CE  1 
ATOM   1380 N  N   . TRP A 1 215 ? -26.578 -23.696 -8.648  0.50 56.54  ? 478  TRP A N   1 
ATOM   1381 C  CA  . TRP A 1 215 ? -28.048 -23.887 -8.520  0.50 57.38  ? 478  TRP A CA  1 
ATOM   1382 C  C   . TRP A 1 215 ? -28.634 -24.120 -9.922  0.50 55.53  ? 478  TRP A C   1 
ATOM   1383 O  O   . TRP A 1 215 ? -27.993 -23.703 -10.910 0.50 50.86  ? 478  TRP A O   1 
ATOM   1384 C  CB  . TRP A 1 215 ? -28.702 -22.723 -7.755  0.50 56.52  ? 478  TRP A CB  1 
ATOM   1385 C  CG  . TRP A 1 215 ? -29.012 -21.486 -8.541  0.50 57.43  ? 478  TRP A CG  1 
ATOM   1386 C  CD1 . TRP A 1 215 ? -28.125 -20.593 -9.071  0.50 59.36  ? 478  TRP A CD1 1 
ATOM   1387 C  CD2 . TRP A 1 215 ? -30.320 -20.961 -8.830  0.50 57.92  ? 478  TRP A CD2 1 
ATOM   1388 N  NE1 . TRP A 1 215 ? -28.788 -19.569 -9.695  0.50 59.02  ? 478  TRP A NE1 1 
ATOM   1389 C  CE2 . TRP A 1 215 ? -30.137 -19.767 -9.564  0.50 59.68  ? 478  TRP A CE2 1 
ATOM   1390 C  CE3 . TRP A 1 215 ? -31.623 -21.390 -8.557  0.50 56.50  ? 478  TRP A CE3 1 
ATOM   1391 C  CZ2 . TRP A 1 215 ? -31.207 -19.001 -10.022 0.50 58.23  ? 478  TRP A CZ2 1 
ATOM   1392 C  CZ3 . TRP A 1 215 ? -32.680 -20.637 -9.017  0.50 58.37  ? 478  TRP A CZ3 1 
ATOM   1393 C  CH2 . TRP A 1 215 ? -32.473 -19.459 -9.738  0.50 60.13  ? 478  TRP A CH2 1 
ATOM   1394 N  N   . LEU A 1 216 ? -29.766 -24.822 -10.003 0.50 55.54  ? 479  LEU A N   1 
ATOM   1395 C  CA  . LEU A 1 216 ? -30.380 -25.279 -11.278 0.50 56.79  ? 479  LEU A CA  1 
ATOM   1396 C  C   . LEU A 1 216 ? -30.582 -24.077 -12.207 0.50 57.97  ? 479  LEU A C   1 
ATOM   1397 O  O   . LEU A 1 216 ? -30.276 -24.205 -13.405 0.50 58.50  ? 479  LEU A O   1 
ATOM   1398 C  CB  . LEU A 1 216 ? -31.707 -25.980 -10.975 0.50 58.21  ? 479  LEU A CB  1 
ATOM   1399 C  CG  . LEU A 1 216 ? -32.263 -26.825 -12.119 0.50 60.14  ? 479  LEU A CG  1 
ATOM   1400 C  CD1 . LEU A 1 216 ? -31.265 -27.895 -12.531 0.50 61.64  ? 479  LEU A CD1 1 
ATOM   1401 C  CD2 . LEU A 1 216 ? -33.595 -27.454 -11.739 0.50 61.54  ? 479  LEU A CD2 1 
ATOM   1402 N  N   . GLY A 1 217 ? -31.060 -22.955 -11.661 0.50 56.85  ? 480  GLY A N   1 
ATOM   1403 C  CA  . GLY A 1 217 ? -31.324 -21.709 -12.406 0.50 57.23  ? 480  GLY A CA  1 
ATOM   1404 C  C   . GLY A 1 217 ? -30.117 -21.266 -13.212 0.50 55.62  ? 480  GLY A C   1 
ATOM   1405 O  O   . GLY A 1 217 ? -30.286 -20.964 -14.408 0.50 54.40  ? 480  GLY A O   1 
ATOM   1406 N  N   . ALA A 1 218 ? -28.940 -21.218 -12.582 0.50 54.30  ? 481  ALA A N   1 
ATOM   1407 C  CA  . ALA A 1 218 ? -27.658 -20.845 -13.227 0.50 51.85  ? 481  ALA A CA  1 
ATOM   1408 C  C   . ALA A 1 218 ? -27.327 -21.877 -14.310 0.50 49.75  ? 481  ALA A C   1 
ATOM   1409 O  O   . ALA A 1 218 ? -26.868 -21.464 -15.390 0.50 49.55  ? 481  ALA A O   1 
ATOM   1410 C  CB  . ALA A 1 218 ? -26.564 -20.744 -12.195 0.50 50.64  ? 481  ALA A CB  1 
ATOM   1411 N  N   . ARG A 1 219 ? -27.576 -23.162 -14.029 0.50 49.36  ? 482  ARG A N   1 
ATOM   1412 C  CA  . ARG A 1 219 ? -27.370 -24.286 -14.983 0.50 49.92  ? 482  ARG A CA  1 
ATOM   1413 C  C   . ARG A 1 219 ? -28.278 -24.081 -16.196 0.50 48.80  ? 482  ARG A C   1 
ATOM   1414 O  O   . ARG A 1 219 ? -27.759 -24.079 -17.327 0.50 42.60  ? 482  ARG A O   1 
ATOM   1415 C  CB  . ARG A 1 219 ? -27.660 -25.640 -14.332 0.50 51.45  ? 482  ARG A CB  1 
ATOM   1416 C  CG  . ARG A 1 219 ? -26.408 -26.407 -13.936 0.50 57.17  ? 482  ARG A CG  1 
ATOM   1417 C  CD  . ARG A 1 219 ? -25.508 -25.567 -13.051 0.50 58.75  ? 482  ARG A CD  1 
ATOM   1418 N  NE  . ARG A 1 219 ? -24.307 -26.268 -12.615 0.50 61.01  ? 482  ARG A NE  1 
ATOM   1419 C  CZ  . ARG A 1 219 ? -23.108 -26.116 -13.161 0.50 59.17  ? 482  ARG A CZ  1 
ATOM   1420 N  NH1 . ARG A 1 219 ? -22.947 -25.296 -14.186 0.50 59.21  ? 482  ARG A NH1 1 
ATOM   1421 N  NH2 . ARG A 1 219 ? -22.077 -26.787 -12.680 0.50 59.32  ? 482  ARG A NH2 1 
ATOM   1422 N  N   . PHE A 1 220 ? -29.583 -23.901 -15.971 0.50 48.32  ? 483  PHE A N   1 
ATOM   1423 C  CA  . PHE A 1 220 ? -30.556 -23.669 -17.066 0.50 47.95  ? 483  PHE A CA  1 
ATOM   1424 C  C   . PHE A 1 220 ? -30.009 -22.591 -18.004 0.50 45.90  ? 483  PHE A C   1 
ATOM   1425 O  O   . PHE A 1 220 ? -29.895 -22.854 -19.218 0.50 49.06  ? 483  PHE A O   1 
ATOM   1426 C  CB  . PHE A 1 220 ? -31.933 -23.218 -16.575 0.50 48.73  ? 483  PHE A CB  1 
ATOM   1427 C  CG  . PHE A 1 220 ? -32.773 -22.726 -17.722 0.50 46.65  ? 483  PHE A CG  1 
ATOM   1428 C  CD1 . PHE A 1 220 ? -33.259 -23.618 -18.664 0.50 50.63  ? 483  PHE A CD1 1 
ATOM   1429 C  CD2 . PHE A 1 220 ? -32.982 -21.374 -17.924 0.50 48.03  ? 483  PHE A CD2 1 
ATOM   1430 C  CE1 . PHE A 1 220 ? -33.988 -23.170 -19.754 0.50 51.09  ? 483  PHE A CE1 1 
ATOM   1431 C  CE2 . PHE A 1 220 ? -33.713 -20.927 -19.013 0.50 49.69  ? 483  PHE A CE2 1 
ATOM   1432 C  CZ  . PHE A 1 220 ? -34.212 -21.825 -19.926 0.50 50.33  ? 483  PHE A CZ  1 
ATOM   1433 N  N   . LEU A 1 221 ? -29.707 -21.413 -17.449 0.50 44.87  ? 484  LEU A N   1 
ATOM   1434 C  CA  . LEU A 1 221 ? -29.187 -20.237 -18.196 0.50 45.27  ? 484  LEU A CA  1 
ATOM   1435 C  C   . LEU A 1 221 ? -27.968 -20.665 -19.018 0.50 43.67  ? 484  LEU A C   1 
ATOM   1436 O  O   . LEU A 1 221 ? -27.909 -20.328 -20.222 0.50 40.36  ? 484  LEU A O   1 
ATOM   1437 C  CB  . LEU A 1 221 ? -28.836 -19.121 -17.206 0.50 45.88  ? 484  LEU A CB  1 
ATOM   1438 C  CG  . LEU A 1 221 ? -30.032 -18.391 -16.595 0.50 47.39  ? 484  LEU A CG  1 
ATOM   1439 C  CD1 . LEU A 1 221 ? -29.581 -17.159 -15.822 0.50 49.69  ? 484  LEU A CD1 1 
ATOM   1440 C  CD2 . LEU A 1 221 ? -31.037 -18.001 -17.668 0.50 48.55  ? 484  LEU A CD2 1 
ATOM   1441 N  N   . GLU A 1 222 ? -27.028 -21.379 -18.391 0.50 41.87  ? 485  GLU A N   1 
ATOM   1442 C  CA  . GLU A 1 222 ? -25.817 -21.898 -19.078 0.50 41.66  ? 485  GLU A CA  1 
ATOM   1443 C  C   . GLU A 1 222 ? -26.284 -22.755 -20.264 0.50 39.22  ? 485  GLU A C   1 
ATOM   1444 O  O   . GLU A 1 222 ? -25.773 -22.561 -21.377 0.50 38.73  ? 485  GLU A O   1 
ATOM   1445 C  CB  . GLU A 1 222 ? -24.937 -22.669 -18.086 0.50 42.90  ? 485  GLU A CB  1 
ATOM   1446 C  CG  . GLU A 1 222 ? -23.578 -23.044 -18.647 0.50 43.17  ? 485  GLU A CG  1 
ATOM   1447 C  CD  . GLU A 1 222 ? -22.864 -24.152 -17.891 0.50 42.97  ? 485  GLU A CD  1 
ATOM   1448 O  OE1 . GLU A 1 222 ? -21.781 -23.877 -17.321 0.50 41.61  ? 485  GLU A OE1 1 
ATOM   1449 O  OE2 . GLU A 1 222 ? -23.386 -25.288 -17.884 0.50 40.10  ? 485  GLU A OE2 1 
ATOM   1450 N  N   . PHE A 1 223 ? -27.256 -23.639 -20.036 0.50 38.83  ? 486  PHE A N   1 
ATOM   1451 C  CA  . PHE A 1 223 ? -27.799 -24.587 -21.043 0.50 40.87  ? 486  PHE A CA  1 
ATOM   1452 C  C   . PHE A 1 223 ? -28.504 -23.811 -22.163 0.50 44.10  ? 486  PHE A C   1 
ATOM   1453 O  O   . PHE A 1 223 ? -28.336 -24.186 -23.344 0.50 41.21  ? 486  PHE A O   1 
ATOM   1454 C  CB  . PHE A 1 223 ? -28.731 -25.595 -20.370 0.50 42.25  ? 486  PHE A CB  1 
ATOM   1455 C  CG  . PHE A 1 223 ? -29.456 -26.510 -21.324 0.50 41.65  ? 486  PHE A CG  1 
ATOM   1456 C  CD1 . PHE A 1 223 ? -28.780 -27.508 -22.004 0.50 40.92  ? 486  PHE A CD1 1 
ATOM   1457 C  CD2 . PHE A 1 223 ? -30.816 -26.366 -21.545 0.50 41.55  ? 486  PHE A CD2 1 
ATOM   1458 C  CE1 . PHE A 1 223 ? -29.448 -28.341 -22.889 0.50 43.40  ? 486  PHE A CE1 1 
ATOM   1459 C  CE2 . PHE A 1 223 ? -31.484 -27.203 -22.423 0.50 42.22  ? 486  PHE A CE2 1 
ATOM   1460 C  CZ  . PHE A 1 223 ? -30.800 -28.191 -23.093 0.50 43.08  ? 486  PHE A CZ  1 
ATOM   1461 N  N   . GLU A 1 224 ? -29.244 -22.752 -21.811 1.00 45.43  ? 487  GLU A N   1 
ATOM   1462 C  CA  . GLU A 1 224 ? -30.028 -21.947 -22.794 1.00 44.78  ? 487  GLU A CA  1 
ATOM   1463 C  C   . GLU A 1 224 ? -29.058 -21.285 -23.785 1.00 47.30  ? 487  GLU A C   1 
ATOM   1464 O  O   . GLU A 1 224 ? -29.349 -21.226 -25.011 1.00 43.48  ? 487  GLU A O   1 
ATOM   1465 C  CB  . GLU A 1 224 ? -30.907 -20.939 -22.034 1.00 51.49  ? 487  GLU A CB  1 
ATOM   1466 C  CG  . GLU A 1 224 ? -31.137 -19.610 -22.753 1.00 56.30  ? 487  GLU A CG  1 
ATOM   1467 C  CD  . GLU A 1 224 ? -32.161 -18.682 -22.110 1.00 55.86  ? 487  GLU A CD  1 
ATOM   1468 O  OE1 . GLU A 1 224 ? -33.370 -18.890 -22.357 1.00 55.52  ? 487  GLU A OE1 1 
ATOM   1469 O  OE2 . GLU A 1 224 ? -31.746 -17.742 -21.390 1.00 49.87  ? 487  GLU A OE2 1 
ATOM   1470 N  N   . ALA A 1 225 ? -27.893 -20.865 -23.304 1.00 37.90  ? 488  ALA A N   1 
ATOM   1471 C  CA  . ALA A 1 225 ? -26.972 -20.051 -24.110 1.00 38.91  ? 488  ALA A CA  1 
ATOM   1472 C  C   . ALA A 1 225 ? -25.992 -20.947 -24.874 1.00 38.35  ? 488  ALA A C   1 
ATOM   1473 O  O   . ALA A 1 225 ? -25.590 -20.517 -25.987 1.00 36.30  ? 488  ALA A O   1 
ATOM   1474 C  CB  . ALA A 1 225 ? -26.268 -19.059 -23.240 1.00 42.29  ? 488  ALA A CB  1 
ATOM   1475 N  N   . LEU A 1 226 ? -25.576 -22.084 -24.299 1.00 38.33  ? 489  LEU A N   1 
ATOM   1476 C  CA  . LEU A 1 226 ? -24.391 -22.847 -24.814 1.00 35.04  ? 489  LEU A CA  1 
ATOM   1477 C  C   . LEU A 1 226 ? -24.699 -24.336 -24.945 1.00 34.44  ? 489  LEU A C   1 
ATOM   1478 O  O   . LEU A 1 226 ? -23.814 -25.074 -25.472 1.00 34.02  ? 489  LEU A O   1 
ATOM   1479 C  CB  . LEU A 1 226 ? -23.168 -22.603 -23.918 1.00 33.88  ? 489  LEU A CB  1 
ATOM   1480 C  CG  . LEU A 1 226 ? -22.650 -21.165 -23.836 1.00 36.69  ? 489  LEU A CG  1 
ATOM   1481 C  CD1 . LEU A 1 226 ? -21.476 -21.043 -22.854 1.00 41.93  ? 489  LEU A CD1 1 
ATOM   1482 C  CD2 . LEU A 1 226 ? -22.193 -20.655 -25.195 1.00 42.50  ? 489  LEU A CD2 1 
ATOM   1483 N  N   . GLY A 1 227 ? -25.924 -24.794 -24.605 1.00 30.57  ? 490  GLY A N   1 
ATOM   1484 C  CA  . GLY A 1 227 ? -26.296 -26.207 -24.751 1.00 30.63  ? 490  GLY A CA  1 
ATOM   1485 C  C   . GLY A 1 227 ? -26.280 -26.701 -26.170 1.00 29.59  ? 490  GLY A C   1 
ATOM   1486 O  O   . GLY A 1 227 ? -26.079 -27.929 -26.381 1.00 30.13  ? 490  GLY A O   1 
ATOM   1487 N  N   . PHE A 1 228 ? -26.429 -25.800 -27.136 1.00 31.92  ? 491  PHE A N   1 
ATOM   1488 C  CA  . PHE A 1 228 ? -26.458 -26.158 -28.575 1.00 32.30  ? 491  PHE A CA  1 
ATOM   1489 C  C   . PHE A 1 228 ? -25.172 -26.886 -28.968 1.00 28.36  ? 491  PHE A C   1 
ATOM   1490 O  O   . PHE A 1 228 ? -25.224 -27.750 -29.861 1.00 28.66  ? 491  PHE A O   1 
ATOM   1491 C  CB  . PHE A 1 228 ? -26.658 -24.942 -29.475 1.00 31.56  ? 491  PHE A CB  1 
ATOM   1492 C  CG  . PHE A 1 228 ? -25.516 -23.983 -29.557 1.00 28.59  ? 491  PHE A CG  1 
ATOM   1493 C  CD1 . PHE A 1 228 ? -25.364 -22.975 -28.628 1.00 35.83  ? 491  PHE A CD1 1 
ATOM   1494 C  CD2 . PHE A 1 228 ? -24.567 -24.111 -30.538 1.00 33.03  ? 491  PHE A CD2 1 
ATOM   1495 C  CE1 . PHE A 1 228 ? -24.297 -22.095 -28.691 1.00 32.59  ? 491  PHE A CE1 1 
ATOM   1496 C  CE2 . PHE A 1 228 ? -23.485 -23.249 -30.592 1.00 30.21  ? 491  PHE A CE2 1 
ATOM   1497 C  CZ  . PHE A 1 228 ? -23.346 -22.231 -29.670 1.00 33.09  ? 491  PHE A CZ  1 
ATOM   1498 N  N   . LEU A 1 229 ? -24.052 -26.562 -28.329 1.00 32.08  ? 492  LEU A N   1 
ATOM   1499 C  CA  . LEU A 1 229 ? -22.757 -27.233 -28.677 1.00 30.63  ? 492  LEU A CA  1 
ATOM   1500 C  C   . LEU A 1 229 ? -22.926 -28.745 -28.553 1.00 27.48  ? 492  LEU A C   1 
ATOM   1501 O  O   . LEU A 1 229 ? -22.541 -29.493 -29.487 1.00 32.73  ? 492  LEU A O   1 
ATOM   1502 C  CB  . LEU A 1 229 ? -21.649 -26.677 -27.772 1.00 31.06  ? 492  LEU A CB  1 
ATOM   1503 C  CG  . LEU A 1 229 ? -21.187 -25.254 -28.107 1.00 33.00  ? 492  LEU A CG  1 
ATOM   1504 C  CD1 . LEU A 1 229 ? -20.179 -24.781 -27.102 1.00 34.77  ? 492  LEU A CD1 1 
ATOM   1505 C  CD2 . LEU A 1 229 ? -20.617 -25.129 -29.524 1.00 32.66  ? 492  LEU A CD2 1 
ATOM   1506 N  N   . ASN A 1 230 ? -23.505 -29.202 -27.455 1.00 28.73  ? 493  ASN A N   1 
ATOM   1507 C  CA  . ASN A 1 230 ? -23.732 -30.653 -27.221 1.00 28.76  ? 493  ASN A CA  1 
ATOM   1508 C  C   . ASN A 1 230 ? -25.030 -31.121 -27.881 1.00 31.45  ? 493  ASN A C   1 
ATOM   1509 O  O   . ASN A 1 230 ? -25.029 -32.182 -28.562 1.00 28.22  ? 493  ASN A O   1 
ATOM   1510 C  CB  . ASN A 1 230 ? -23.774 -30.943 -25.731 1.00 35.05  ? 493  ASN A CB  1 
ATOM   1511 C  CG  . ASN A 1 230 ? -23.869 -32.420 -25.454 1.00 39.36  ? 493  ASN A CG  1 
ATOM   1512 O  OD1 . ASN A 1 230 ? -24.892 -32.914 -24.966 1.00 41.56  ? 493  ASN A OD1 1 
ATOM   1513 N  ND2 . ASN A 1 230 ? -22.814 -33.128 -25.791 1.00 36.94  ? 493  ASN A ND2 1 
ATOM   1514 N  N   . GLU A 1 231 ? -26.126 -30.382 -27.703 1.00 32.58  ? 494  GLU A N   1 
ATOM   1515 C  CA  . GLU A 1 231 ? -27.449 -30.869 -28.210 1.00 33.31  ? 494  GLU A CA  1 
ATOM   1516 C  C   . GLU A 1 231 ? -27.427 -31.026 -29.734 1.00 31.89  ? 494  GLU A C   1 
ATOM   1517 O  O   . GLU A 1 231 ? -28.177 -31.880 -30.227 1.00 31.91  ? 494  GLU A O   1 
ATOM   1518 C  CB  . GLU A 1 231 ? -28.553 -29.880 -27.821 1.00 36.87  ? 494  GLU A CB  1 
ATOM   1519 C  CG  . GLU A 1 231 ? -28.826 -29.804 -26.340 1.00 41.11  ? 494  GLU A CG  1 
ATOM   1520 C  CD  . GLU A 1 231 ? -29.342 -31.095 -25.730 1.00 46.80  ? 494  GLU A CD  1 
ATOM   1521 O  OE1 . GLU A 1 231 ? -30.289 -31.686 -26.281 1.00 50.58  ? 494  GLU A OE1 1 
ATOM   1522 O  OE2 . GLU A 1 231 ? -28.770 -31.510 -24.725 1.00 50.46  ? 494  GLU A OE2 1 
ATOM   1523 N  N   . ASP A 1 232 ? -26.682 -30.178 -30.467 1.00 29.15  ? 495  ASP A N   1 
ATOM   1524 C  CA  . ASP A 1 232 ? -26.642 -30.184 -31.948 1.00 27.82  ? 495  ASP A CA  1 
ATOM   1525 C  C   . ASP A 1 232 ? -25.284 -30.725 -32.441 1.00 33.57  ? 495  ASP A C   1 
ATOM   1526 O  O   . ASP A 1 232 ? -24.985 -30.614 -33.637 1.00 30.36  ? 495  ASP A O   1 
ATOM   1527 C  CB  . ASP A 1 232 ? -26.915 -28.781 -32.492 1.00 33.15  ? 495  ASP A CB  1 
ATOM   1528 C  CG  . ASP A 1 232 ? -28.293 -28.229 -32.117 1.00 31.41  ? 495  ASP A CG  1 
ATOM   1529 O  OD1 . ASP A 1 232 ? -29.104 -29.016 -31.716 1.00 34.05  ? 495  ASP A OD1 1 
ATOM   1530 O  OD2 . ASP A 1 232 ? -28.436 -27.020 -32.092 1.00 33.74  ? 495  ASP A OD2 1 
ATOM   1531 N  N   . HIS A 1 233 ? -24.528 -31.383 -31.565 1.00 31.42  ? 496  HIS A N   1 
ATOM   1532 C  CA  . HIS A 1 233 ? -23.413 -32.289 -31.964 1.00 30.80  ? 496  HIS A CA  1 
ATOM   1533 C  C   . HIS A 1 233 ? -22.341 -31.528 -32.741 1.00 25.03  ? 496  HIS A C   1 
ATOM   1534 O  O   . HIS A 1 233 ? -21.839 -32.061 -33.754 1.00 29.48  ? 496  HIS A O   1 
ATOM   1535 C  CB  . HIS A 1 233 ? -23.927 -33.466 -32.793 1.00 33.12  ? 496  HIS A CB  1 
ATOM   1536 C  CG  . HIS A 1 233 ? -25.069 -34.188 -32.169 1.00 39.69  ? 496  HIS A CG  1 
ATOM   1537 N  ND1 . HIS A 1 233 ? -24.940 -34.877 -30.998 1.00 42.84  ? 496  HIS A ND1 1 
ATOM   1538 C  CD2 . HIS A 1 233 ? -26.384 -34.248 -32.511 1.00 45.11  ? 496  HIS A CD2 1 
ATOM   1539 C  CE1 . HIS A 1 233 ? -26.119 -35.386 -30.650 1.00 44.02  ? 496  HIS A CE1 1 
ATOM   1540 N  NE2 . HIS A 1 233 ? -27.013 -35.028 -31.577 1.00 42.84  ? 496  HIS A NE2 1 
ATOM   1541 N  N   . TRP A 1 234 ? -21.940 -30.380 -32.254 1.00 24.84  ? 497  TRP A N   1 
ATOM   1542 C  CA  . TRP A 1 234 ? -20.879 -29.555 -32.890 1.00 26.65  ? 497  TRP A CA  1 
ATOM   1543 C  C   . TRP A 1 234 ? -19.531 -30.326 -32.946 1.00 26.84  ? 497  TRP A C   1 
ATOM   1544 O  O   . TRP A 1 234 ? -18.730 -30.109 -33.891 1.00 25.49  ? 497  TRP A O   1 
ATOM   1545 C  CB  . TRP A 1 234 ? -20.729 -28.207 -32.187 1.00 28.08  ? 497  TRP A CB  1 
ATOM   1546 C  CG  . TRP A 1 234 ? -21.737 -27.199 -32.664 1.00 32.68  ? 497  TRP A CG  1 
ATOM   1547 C  CD1 . TRP A 1 234 ? -23.095 -27.381 -32.732 1.00 32.15  ? 497  TRP A CD1 1 
ATOM   1548 C  CD2 . TRP A 1 234 ? -21.475 -25.894 -33.225 1.00 29.80  ? 497  TRP A CD2 1 
ATOM   1549 N  NE1 . TRP A 1 234 ? -23.687 -26.264 -33.278 1.00 33.86  ? 497  TRP A NE1 1 
ATOM   1550 C  CE2 . TRP A 1 234 ? -22.732 -25.337 -33.589 1.00 30.60  ? 497  TRP A CE2 1 
ATOM   1551 C  CE3 . TRP A 1 234 ? -20.322 -25.124 -33.444 1.00 30.16  ? 497  TRP A CE3 1 
ATOM   1552 C  CZ2 . TRP A 1 234 ? -22.847 -24.058 -34.145 1.00 31.40  ? 497  TRP A CZ2 1 
ATOM   1553 C  CZ3 . TRP A 1 234 ? -20.439 -23.859 -34.003 1.00 33.73  ? 497  TRP A CZ3 1 
ATOM   1554 C  CH2 . TRP A 1 234 ? -21.693 -23.337 -34.358 1.00 31.23  ? 497  TRP A CH2 1 
ATOM   1555 N  N   . PHE A 1 235 ? -19.281 -31.168 -31.940 0.50 27.05  ? 498  PHE A N   1 
ATOM   1556 C  CA  . PHE A 1 235 ? -18.007 -31.912 -31.760 0.50 26.62  ? 498  PHE A CA  1 
ATOM   1557 C  C   . PHE A 1 235 ? -18.170 -33.369 -32.195 0.50 28.03  ? 498  PHE A C   1 
ATOM   1558 O  O   . PHE A 1 235 ? -17.329 -34.204 -31.774 0.50 26.16  ? 498  PHE A O   1 
ATOM   1559 C  CB  . PHE A 1 235 ? -17.512 -31.718 -30.324 0.50 26.95  ? 498  PHE A CB  1 
ATOM   1560 C  CG  . PHE A 1 235 ? -17.220 -30.272 -30.021 0.50 26.98  ? 498  PHE A CG  1 
ATOM   1561 C  CD1 . PHE A 1 235 ? -16.137 -29.641 -30.610 0.50 26.78  ? 498  PHE A CD1 1 
ATOM   1562 C  CD2 . PHE A 1 235 ? -18.069 -29.522 -29.226 0.50 27.38  ? 498  PHE A CD2 1 
ATOM   1563 C  CE1 . PHE A 1 235 ? -15.886 -28.300 -30.381 0.50 28.55  ? 498  PHE A CE1 1 
ATOM   1564 C  CE2 . PHE A 1 235 ? -17.814 -28.176 -28.998 0.50 28.57  ? 498  PHE A CE2 1 
ATOM   1565 C  CZ  . PHE A 1 235 ? -16.727 -27.567 -29.576 0.50 28.33  ? 498  PHE A CZ  1 
ATOM   1566 N  N   . SER A 1 236 ? -19.177 -33.672 -33.030 0.50 27.23  ? 499  SER A N   1 
ATOM   1567 C  CA  . SER A 1 236 ? -19.303 -34.962 -33.764 0.50 27.19  ? 499  SER A CA  1 
ATOM   1568 C  C   . SER A 1 236 ? -18.076 -35.137 -34.665 0.50 26.58  ? 499  SER A C   1 
ATOM   1569 O  O   . SER A 1 236 ? -17.506 -34.104 -35.035 0.50 28.08  ? 499  SER A O   1 
ATOM   1570 C  CB  . SER A 1 236 ? -20.559 -34.983 -34.598 0.50 27.79  ? 499  SER A CB  1 
ATOM   1571 O  OG  . SER A 1 236 ? -20.572 -33.883 -35.506 0.50 25.89  ? 499  SER A OG  1 
ATOM   1572 N  N   . ARG A 1 237 ? -17.710 -36.369 -35.041 1.00 25.05  ? 500  ARG A N   1 
ATOM   1573 C  CA  . ARG A 1 237 ? -16.605 -36.555 -36.000 1.00 26.70  ? 500  ARG A CA  1 
ATOM   1574 C  C   . ARG A 1 237 ? -16.977 -35.960 -37.376 1.00 30.33  ? 500  ARG A C   1 
ATOM   1575 O  O   . ARG A 1 237 ? -16.123 -35.304 -38.009 1.00 28.12  ? 500  ARG A O   1 
ATOM   1576 C  CB  . ARG A 1 237 ? -16.169 -38.014 -36.056 1.00 27.66  ? 500  ARG A CB  1 
ATOM   1577 C  CG  . ARG A 1 237 ? -14.787 -38.158 -36.656 1.00 27.17  ? 500  ARG A CG  1 
ATOM   1578 C  CD  . ARG A 1 237 ? -14.093 -39.427 -36.259 1.00 27.09  ? 500  ARG A CD  1 
ATOM   1579 N  NE  . ARG A 1 237 ? -12.734 -39.393 -36.724 1.00 24.05  ? 500  ARG A NE  1 
ATOM   1580 C  CZ  . ARG A 1 237 ? -11.721 -38.765 -36.118 1.00 27.42  ? 500  ARG A CZ  1 
ATOM   1581 N  NH1 . ARG A 1 237 ? -11.917 -38.107 -34.996 1.00 23.41  ? 500  ARG A NH1 1 
ATOM   1582 N  NH2 . ARG A 1 237 ? -10.503 -38.821 -36.642 1.00 26.74  ? 500  ARG A NH2 1 
ATOM   1583 N  N   . GLU A 1 238 ? -18.270 -35.985 -37.731 0.50 29.22  ? 501  GLU A N   1 
ATOM   1584 C  CA  . GLU A 1 238 ? -18.834 -35.338 -38.953 0.50 29.59  ? 501  GLU A CA  1 
ATOM   1585 C  C   . GLU A 1 238 ? -18.577 -33.820 -38.952 0.50 27.02  ? 501  GLU A C   1 
ATOM   1586 O  O   . GLU A 1 238 ? -17.987 -33.337 -39.924 0.50 26.14  ? 501  GLU A O   1 
ATOM   1587 C  CB  . GLU A 1 238 ? -20.331 -35.655 -39.072 0.50 32.58  ? 501  GLU A CB  1 
ATOM   1588 C  CG  . GLU A 1 238 ? -20.976 -35.142 -40.352 0.50 35.71  ? 501  GLU A CG  1 
ATOM   1589 C  CD  . GLU A 1 238 ? -22.355 -35.731 -40.625 0.50 42.27  ? 501  GLU A CD  1 
ATOM   1590 O  OE1 . GLU A 1 238 ? -22.621 -36.100 -41.801 0.50 45.18  ? 501  GLU A OE1 1 
ATOM   1591 O  OE2 . GLU A 1 238 ? -23.163 -35.840 -39.662 0.50 43.26  ? 501  GLU A OE2 1 
ATOM   1592 N  N   . ASN A 1 239 ? -18.975 -33.079 -37.912 0.50 26.07  ? 502  ASN A N   1 
ATOM   1593 C  CA  . ASN A 1 239 ? -18.885 -31.593 -37.921 0.50 27.43  ? 502  ASN A CA  1 
ATOM   1594 C  C   . ASN A 1 239 ? -17.473 -31.080 -37.626 0.50 26.20  ? 502  ASN A C   1 
ATOM   1595 O  O   . ASN A 1 239 ? -17.175 -29.987 -38.103 0.50 23.86  ? 502  ASN A O   1 
ATOM   1596 C  CB  . ASN A 1 239 ? -19.819 -30.895 -36.931 0.50 27.15  ? 502  ASN A CB  1 
ATOM   1597 C  CG  . ASN A 1 239 ? -19.780 -29.393 -37.134 0.50 28.12  ? 502  ASN A CG  1 
ATOM   1598 O  OD1 . ASN A 1 239 ? -19.980 -28.922 -38.252 0.50 30.63  ? 502  ASN A OD1 1 
ATOM   1599 N  ND2 . ASN A 1 239 ? -19.536 -28.633 -36.079 0.50 24.09  ? 502  ASN A ND2 1 
ATOM   1600 N  N   . SER A 1 240 ? -16.665 -31.808 -36.841 0.50 26.54  ? 503  SER A N   1 
ATOM   1601 C  CA  . SER A 1 240 ? -15.385 -31.321 -36.253 0.50 26.01  ? 503  SER A CA  1 
ATOM   1602 C  C   . SER A 1 240 ? -14.154 -32.006 -36.874 0.50 26.00  ? 503  SER A C   1 
ATOM   1603 O  O   . SER A 1 240 ? -13.069 -31.402 -36.776 0.50 26.83  ? 503  SER A O   1 
ATOM   1604 C  CB  . SER A 1 240 ? -15.392 -31.522 -34.762 0.50 27.28  ? 503  SER A CB  1 
ATOM   1605 O  OG  . SER A 1 240 ? -15.373 -32.921 -34.459 0.50 24.56  ? 503  SER A OG  1 
ATOM   1606 N  N   . LEU A 1 241 ? -14.303 -33.194 -37.475 1.00 24.74  ? 504  LEU A N   1 
ATOM   1607 C  CA  . LEU A 1 241 ? -13.181 -34.024 -38.046 1.00 27.52  ? 504  LEU A CA  1 
ATOM   1608 C  C   . LEU A 1 241 ? -12.260 -34.672 -36.979 1.00 24.24  ? 504  LEU A C   1 
ATOM   1609 O  O   . LEU A 1 241 ? -11.887 -35.835 -37.156 1.00 26.40  ? 504  LEU A O   1 
ATOM   1610 C  CB  . LEU A 1 241 ? -12.367 -33.231 -39.065 1.00 29.17  ? 504  LEU A CB  1 
ATOM   1611 C  CG  . LEU A 1 241 ? -13.158 -32.512 -40.162 1.00 36.01  ? 504  LEU A CG  1 
ATOM   1612 C  CD1 . LEU A 1 241 ? -12.228 -31.883 -41.200 1.00 39.04  ? 504  LEU A CD1 1 
ATOM   1613 C  CD2 . LEU A 1 241 ? -14.096 -33.462 -40.847 1.00 40.57  ? 504  LEU A CD2 1 
ATOM   1614 N  N   . SER A 1 242 ? -11.927 -33.958 -35.904 0.50 24.38  ? 505  SER A N   1 
ATOM   1615 C  CA  . SER A 1 242 ? -11.073 -34.482 -34.800 0.50 23.73  ? 505  SER A CA  1 
ATOM   1616 C  C   . SER A 1 242 ? -11.922 -34.966 -33.621 0.50 22.91  ? 505  SER A C   1 
ATOM   1617 O  O   . SER A 1 242 ? -11.399 -35.708 -32.762 0.50 20.29  ? 505  SER A O   1 
ATOM   1618 C  CB  . SER A 1 242 ? -10.097 -33.440 -34.360 0.50 23.36  ? 505  SER A CB  1 
ATOM   1619 O  OG  . SER A 1 242 ? -9.293  -33.060 -35.458 0.50 23.67  ? 505  SER A OG  1 
ATOM   1620 N  N   . GLY A 1 243 ? -13.169 -34.510 -33.531 1.00 24.38  ? 506  GLY A N   1 
ATOM   1621 C  CA  . GLY A 1 243 ? -14.030 -34.910 -32.410 1.00 22.47  ? 506  GLY A CA  1 
ATOM   1622 C  C   . GLY A 1 243 ? -14.540 -36.330 -32.516 1.00 22.95  ? 506  GLY A C   1 
ATOM   1623 O  O   . GLY A 1 243 ? -14.465 -36.947 -33.577 1.00 24.42  ? 506  GLY A O   1 
ATOM   1624 N  N   . VAL A 1 244 ? -15.091 -36.806 -31.402 1.00 22.21  ? 507  VAL A N   1 
ATOM   1625 C  CA  . VAL A 1 244 ? -15.685 -38.148 -31.279 1.00 25.93  ? 507  VAL A CA  1 
ATOM   1626 C  C   . VAL A 1 244 ? -16.984 -38.034 -30.467 1.00 26.56  ? 507  VAL A C   1 
ATOM   1627 O  O   . VAL A 1 244 ? -17.414 -39.040 -29.943 1.00 24.93  ? 507  VAL A O   1 
ATOM   1628 C  CB  . VAL A 1 244 ? -14.718 -39.164 -30.623 1.00 25.05  ? 507  VAL A CB  1 
ATOM   1629 C  CG1 . VAL A 1 244 ? -13.559 -39.485 -31.526 1.00 26.23  ? 507  VAL A CG1 1 
ATOM   1630 C  CG2 . VAL A 1 244 ? -14.247 -38.719 -29.250 1.00 26.65  ? 507  VAL A CG2 1 
ATOM   1631 N  N   . GLU A 1 245 ? -17.584 -36.858 -30.361 1.00 26.26  ? 508  GLU A N   1 
ATOM   1632 C  CA  . GLU A 1 245 ? -18.819 -36.704 -29.517 1.00 31.80  ? 508  GLU A CA  1 
ATOM   1633 C  C   . GLU A 1 245 ? -19.928 -37.602 -30.072 1.00 26.96  ? 508  GLU A C   1 
ATOM   1634 O  O   . GLU A 1 245 ? -20.131 -37.647 -31.283 1.00 27.75  ? 508  GLU A O   1 
ATOM   1635 C  CB  . GLU A 1 245 ? -19.293 -35.255 -29.457 1.00 32.84  ? 508  GLU A CB  1 
ATOM   1636 C  CG  . GLU A 1 245 ? -20.397 -35.012 -28.411 1.00 42.21  ? 508  GLU A CG  1 
ATOM   1637 C  CD  . GLU A 1 245 ? -21.821 -35.294 -28.874 1.00 45.24  ? 508  GLU A CD  1 
ATOM   1638 O  OE1 . GLU A 1 245 ? -22.112 -35.117 -30.083 1.00 56.47  ? 508  GLU A OE1 1 
ATOM   1639 O  OE2 . GLU A 1 245 ? -22.646 -35.726 -28.028 1.00 60.14  ? 508  GLU A OE2 1 
ATOM   1640 N  N   . GLY A 1 246 ? -20.564 -38.395 -29.219 1.00 31.60  ? 509  GLY A N   1 
ATOM   1641 C  CA  . GLY A 1 246 ? -21.628 -39.321 -29.662 1.00 31.68  ? 509  GLY A CA  1 
ATOM   1642 C  C   . GLY A 1 246 ? -21.161 -40.631 -30.268 1.00 31.65  ? 509  GLY A C   1 
ATOM   1643 O  O   . GLY A 1 246 ? -22.016 -41.423 -30.657 1.00 32.02  ? 509  GLY A O   1 
ATOM   1644 N  N   . GLU A 1 247 ? -19.840 -40.883 -30.248 0.50 28.94  ? 510  GLU A N   1 
ATOM   1645 C  CA  . GLU A 1 247 ? -19.216 -42.180 -30.619 0.50 28.54  ? 510  GLU A CA  1 
ATOM   1646 C  C   . GLU A 1 247 ? -19.111 -43.061 -29.368 0.50 28.81  ? 510  GLU A C   1 
ATOM   1647 O  O   . GLU A 1 247 ? -18.417 -42.658 -28.396 0.50 28.01  ? 510  GLU A O   1 
ATOM   1648 C  CB  . GLU A 1 247 ? -17.811 -42.000 -31.205 0.50 27.52  ? 510  GLU A CB  1 
ATOM   1649 C  CG  . GLU A 1 247 ? -17.752 -41.179 -32.482 0.50 28.10  ? 510  GLU A CG  1 
ATOM   1650 C  CD  . GLU A 1 247 ? -18.408 -41.794 -33.707 0.50 28.70  ? 510  GLU A CD  1 
ATOM   1651 O  OE1 . GLU A 1 247 ? -18.920 -42.921 -33.606 0.50 31.27  ? 510  GLU A OE1 1 
ATOM   1652 O  OE2 . GLU A 1 247 ? -18.417 -41.135 -34.757 0.50 29.22  ? 510  GLU A OE2 1 
ATOM   1653 N  N   . GLY A 1 248 ? -19.745 -44.232 -29.405 0.50 28.92  ? 511  GLY A N   1 
ATOM   1654 C  CA  . GLY A 1 248 ? -19.614 -45.252 -28.351 0.50 29.75  ? 511  GLY A CA  1 
ATOM   1655 C  C   . GLY A 1 248 ? -18.239 -45.901 -28.365 0.50 29.92  ? 511  GLY A C   1 
ATOM   1656 O  O   . GLY A 1 248 ? -17.502 -45.777 -29.370 0.50 25.95  ? 511  GLY A O   1 
ATOM   1657 N  N   A LEU A 1 249 ? -17.916 -46.598 -27.282 0.25 31.66  ? 512  LEU A N   1 
ATOM   1658 N  N   B LEU A 1 249 ? -17.862 -46.619 -27.290 0.25 31.00  ? 512  LEU A N   1 
ATOM   1659 C  CA  A LEU A 1 249 ? -16.659 -47.361 -27.129 0.25 31.84  ? 512  LEU A CA  1 
ATOM   1660 C  CA  B LEU A 1 249 ? -16.568 -47.351 -27.197 0.25 30.85  ? 512  LEU A CA  1 
ATOM   1661 C  C   A LEU A 1 249 ? -16.481 -48.288 -28.329 0.25 31.54  ? 512  LEU A C   1 
ATOM   1662 C  C   B LEU A 1 249 ? -16.456 -48.315 -28.368 0.25 30.97  ? 512  LEU A C   1 
ATOM   1663 O  O   A LEU A 1 249 ? -15.331 -48.609 -28.652 0.25 33.45  ? 512  LEU A O   1 
ATOM   1664 O  O   B LEU A 1 249 ? -15.332 -48.726 -28.691 0.25 32.00  ? 512  LEU A O   1 
ATOM   1665 C  CB  A LEU A 1 249 ? -16.758 -48.149 -25.824 0.25 32.66  ? 512  LEU A CB  1 
ATOM   1666 C  CB  B LEU A 1 249 ? -16.477 -48.130 -25.882 0.25 30.85  ? 512  LEU A CB  1 
ATOM   1667 C  CG  A LEU A 1 249 ? -15.481 -48.257 -25.010 0.25 30.94  ? 512  LEU A CG  1 
ATOM   1668 C  CG  B LEU A 1 249 ? -16.089 -47.314 -24.658 0.25 30.14  ? 512  LEU A CG  1 
ATOM   1669 C  CD1 A LEU A 1 249 ? -14.599 -47.026 -25.184 0.25 31.05  ? 512  LEU A CD1 1 
ATOM   1670 C  CD1 B LEU A 1 249 ? -16.308 -48.122 -23.392 0.25 29.58  ? 512  LEU A CD1 1 
ATOM   1671 C  CD2 A LEU A 1 249 ? -15.826 -48.484 -23.553 0.25 31.18  ? 512  LEU A CD2 1 
ATOM   1672 C  CD2 B LEU A 1 249 ? -14.641 -46.848 -24.759 0.25 30.31  ? 512  LEU A CD2 1 
ATOM   1673 N  N   . HIS A 1 250 ? -17.576 -48.720 -28.958 1.00 29.10  ? 513  HIS A N   1 
ATOM   1674 C  CA  . HIS A 1 250 ? -17.507 -49.675 -30.085 1.00 28.82  ? 513  HIS A CA  1 
ATOM   1675 C  C   . HIS A 1 250 ? -17.044 -49.019 -31.379 1.00 26.57  ? 513  HIS A C   1 
ATOM   1676 O  O   . HIS A 1 250 ? -16.840 -49.740 -32.371 1.00 30.32  ? 513  HIS A O   1 
ATOM   1677 C  CB  . HIS A 1 250 ? -18.854 -50.374 -30.359 1.00 31.52  ? 513  HIS A CB  1 
ATOM   1678 C  CG  . HIS A 1 250 ? -19.966 -49.414 -30.597 1.00 29.80  ? 513  HIS A CG  1 
ATOM   1679 N  ND1 . HIS A 1 250 ? -20.427 -48.575 -29.595 1.00 31.29  ? 513  HIS A ND1 1 
ATOM   1680 C  CD2 . HIS A 1 250 ? -20.694 -49.154 -31.704 1.00 32.89  ? 513  HIS A CD2 1 
ATOM   1681 C  CE1 . HIS A 1 250 ? -21.406 -47.819 -30.095 1.00 32.66  ? 513  HIS A CE1 1 
ATOM   1682 N  NE2 . HIS A 1 250 ? -21.596 -48.175 -31.383 1.00 32.19  ? 513  HIS A NE2 1 
ATOM   1683 N  N   . LYS A 1 251 ? -16.968 -47.684 -31.370 0.34 26.41  ? 514  LYS A N   1 
ATOM   1684 C  CA  . LYS A 1 251 ? -16.572 -46.836 -32.521 0.34 26.22  ? 514  LYS A CA  1 
ATOM   1685 C  C   . LYS A 1 251 ? -15.079 -46.505 -32.419 0.34 25.18  ? 514  LYS A C   1 
ATOM   1686 O  O   . LYS A 1 251 ? -14.375 -46.574 -33.463 0.34 25.05  ? 514  LYS A O   1 
ATOM   1687 C  CB  . LYS A 1 251 ? -17.385 -45.537 -32.519 0.34 27.06  ? 514  LYS A CB  1 
ATOM   1688 C  CG  . LYS A 1 251 ? -18.898 -45.716 -32.565 0.34 28.63  ? 514  LYS A CG  1 
ATOM   1689 C  CD  . LYS A 1 251 ? -19.373 -46.396 -33.820 0.34 29.63  ? 514  LYS A CD  1 
ATOM   1690 C  CE  . LYS A 1 251 ? -20.833 -46.123 -34.111 0.34 30.70  ? 514  LYS A CE  1 
ATOM   1691 N  NZ  . LYS A 1 251 ? -21.057 -45.903 -35.556 0.34 32.42  ? 514  LYS A NZ  1 
ATOM   1692 N  N   . LEU A 1 252 ? -14.626 -46.177 -31.204 1.00 23.98  ? 515  LEU A N   1 
ATOM   1693 C  CA  . LEU A 1 252 ? -13.342 -45.455 -30.976 1.00 23.42  ? 515  LEU A CA  1 
ATOM   1694 C  C   . LEU A 1 252 ? -12.156 -46.219 -31.548 1.00 23.51  ? 515  LEU A C   1 
ATOM   1695 O  O   . LEU A 1 252 ? -11.246 -45.538 -32.136 1.00 21.30  ? 515  LEU A O   1 
ATOM   1696 C  CB  . LEU A 1 252 ? -13.142 -45.130 -29.515 1.00 24.11  ? 515  LEU A CB  1 
ATOM   1697 C  CG  . LEU A 1 252 ? -14.182 -44.245 -28.867 1.00 25.11  ? 515  LEU A CG  1 
ATOM   1698 C  CD1 . LEU A 1 252 ? -13.791 -43.977 -27.428 1.00 26.68  ? 515  LEU A CD1 1 
ATOM   1699 C  CD2 . LEU A 1 252 ? -14.364 -42.936 -29.624 1.00 26.49  ? 515  LEU A CD2 1 
ATOM   1700 N  N   . GLY A 1 253 ? -12.146 -47.549 -31.443 1.00 21.73  ? 516  GLY A N   1 
ATOM   1701 C  CA  . GLY A 1 253 ? -11.009 -48.309 -31.983 1.00 22.55  ? 516  GLY A CA  1 
ATOM   1702 C  C   . GLY A 1 253 ? -10.971 -48.214 -33.505 1.00 25.08  ? 516  GLY A C   1 
ATOM   1703 O  O   . GLY A 1 253 ? -9.856  -48.043 -34.090 1.00 22.46  ? 516  GLY A O   1 
ATOM   1704 N  N   . TYR A 1 254 ? -12.134 -48.305 -34.158 1.00 24.61  ? 517  TYR A N   1 
ATOM   1705 C  CA  . TYR A 1 254 ? -12.199 -48.167 -35.626 1.00 24.74  ? 517  TYR A CA  1 
ATOM   1706 C  C   . TYR A 1 254 ? -11.723 -46.753 -36.050 1.00 22.85  ? 517  TYR A C   1 
ATOM   1707 O  O   . TYR A 1 254 ? -11.021 -46.646 -37.060 1.00 25.01  ? 517  TYR A O   1 
ATOM   1708 C  CB  . TYR A 1 254 ? -13.595 -48.424 -36.177 1.00 25.92  ? 517  TYR A CB  1 
ATOM   1709 C  CG  . TYR A 1 254 ? -14.052 -49.861 -36.185 1.00 22.83  ? 517  TYR A CG  1 
ATOM   1710 C  CD1 . TYR A 1 254 ? -13.523 -50.802 -37.082 1.00 25.22  ? 517  TYR A CD1 1 
ATOM   1711 C  CD2 . TYR A 1 254 ? -15.025 -50.273 -35.295 1.00 23.01  ? 517  TYR A CD2 1 
ATOM   1712 C  CE1 . TYR A 1 254 ? -13.978 -52.112 -37.095 1.00 24.95  ? 517  TYR A CE1 1 
ATOM   1713 C  CE2 . TYR A 1 254 ? -15.498 -51.572 -35.305 1.00 23.02  ? 517  TYR A CE2 1 
ATOM   1714 C  CZ  . TYR A 1 254 ? -14.991 -52.485 -36.218 1.00 23.70  ? 517  TYR A CZ  1 
ATOM   1715 O  OH  . TYR A 1 254 ? -15.482 -53.756 -36.202 1.00 25.44  ? 517  TYR A OH  1 
ATOM   1716 N  N   . ILE A 1 255 ? -12.044 -45.724 -35.285 1.00 23.71  ? 518  ILE A N   1 
ATOM   1717 C  CA  . ILE A 1 255 ? -11.598 -44.353 -35.579 1.00 24.45  ? 518  ILE A CA  1 
ATOM   1718 C  C   . ILE A 1 255 ? -10.071 -44.289 -35.461 1.00 24.67  ? 518  ILE A C   1 
ATOM   1719 O  O   . ILE A 1 255 ? -9.397  -43.714 -36.385 1.00 26.84  ? 518  ILE A O   1 
ATOM   1720 C  CB  . ILE A 1 255 ? -12.344 -43.340 -34.700 1.00 25.83  ? 518  ILE A CB  1 
ATOM   1721 C  CG1 . ILE A 1 255 ? -13.812 -43.252 -35.142 1.00 24.91  ? 518  ILE A CG1 1 
ATOM   1722 C  CG2 . ILE A 1 255 ? -11.611 -41.989 -34.710 1.00 25.47  ? 518  ILE A CG2 1 
ATOM   1723 C  CD1 . ILE A 1 255 ? -14.747 -42.577 -34.104 1.00 26.20  ? 518  ILE A CD1 1 
ATOM   1724 N  N   . LEU A 1 256 ? -9.490  -44.862 -34.416 1.00 23.34  ? 519  LEU A N   1 
ATOM   1725 C  CA  . LEU A 1 256 ? -8.014  -44.818 -34.268 1.00 23.40  ? 519  LEU A CA  1 
ATOM   1726 C  C   . LEU A 1 256 ? -7.348  -45.592 -35.409 1.00 26.20  ? 519  LEU A C   1 
ATOM   1727 O  O   . LEU A 1 256 ? -6.289  -45.148 -35.866 1.00 26.97  ? 519  LEU A O   1 
ATOM   1728 C  CB  . LEU A 1 256 ? -7.581  -45.403 -32.921 1.00 26.00  ? 519  LEU A CB  1 
ATOM   1729 C  CG  . LEU A 1 256 ? -7.965  -44.623 -31.664 1.00 28.76  ? 519  LEU A CG  1 
ATOM   1730 C  CD1 . LEU A 1 256 ? -7.334  -45.294 -30.438 1.00 32.94  ? 519  LEU A CD1 1 
ATOM   1731 C  CD2 . LEU A 1 256 ? -7.514  -43.173 -31.743 1.00 31.89  ? 519  LEU A CD2 1 
ATOM   1732 N  N   . ARG A 1 257 ? -7.918  -46.727 -35.828 1.00 26.93  ? 520  ARG A N   1 
ATOM   1733 C  CA  . ARG A 1 257 ? -7.353  -47.534 -36.942 1.00 27.66  ? 520  ARG A CA  1 
ATOM   1734 C  C   . ARG A 1 257 ? -7.424  -46.690 -38.231 1.00 28.95  ? 520  ARG A C   1 
ATOM   1735 O  O   . ARG A 1 257 ? -6.450  -46.728 -39.044 1.00 26.75  ? 520  ARG A O   1 
ATOM   1736 C  CB  . ARG A 1 257 ? -8.076  -48.874 -37.075 1.00 26.93  ? 520  ARG A CB  1 
ATOM   1737 C  CG  . ARG A 1 257 ? -7.484  -49.772 -38.158 1.00 28.58  ? 520  ARG A CG  1 
ATOM   1738 C  CD  . ARG A 1 257 ? -8.201  -51.100 -38.292 1.00 28.02  ? 520  ARG A CD  1 
ATOM   1739 N  NE  . ARG A 1 257 ? -9.525  -50.940 -38.874 1.00 28.44  ? 520  ARG A NE  1 
ATOM   1740 C  CZ  . ARG A 1 257 ? -10.305 -51.934 -39.317 1.00 27.16  ? 520  ARG A CZ  1 
ATOM   1741 N  NH1 . ARG A 1 257 ? -9.926  -53.186 -39.240 1.00 30.10  ? 520  ARG A NH1 1 
ATOM   1742 N  NH2 . ARG A 1 257 ? -11.458 -51.639 -39.857 1.00 27.42  ? 520  ARG A NH2 1 
ATOM   1743 N  N   . ASP A 1 258 ? -8.475  -45.900 -38.408 1.00 26.46  ? 521  ASP A N   1 
ATOM   1744 C  CA  . ASP A 1 258 ? -8.588  -45.015 -39.619 1.00 28.28  ? 521  ASP A CA  1 
ATOM   1745 C  C   . ASP A 1 258 ? -7.500  -43.923 -39.563 1.00 28.91  ? 521  ASP A C   1 
ATOM   1746 O  O   . ASP A 1 258 ? -6.886  -43.671 -40.575 1.00 30.93  ? 521  ASP A O   1 
ATOM   1747 C  CB  . ASP A 1 258 ? -9.976  -44.411 -39.827 1.00 28.55  ? 521  ASP A CB  1 
ATOM   1748 C  CG  . ASP A 1 258 ? -10.986 -45.345 -40.493 1.00 30.82  ? 521  ASP A CG  1 
ATOM   1749 O  OD1 . ASP A 1 258 ? -10.591 -46.435 -40.941 1.00 32.56  ? 521  ASP A OD1 1 
ATOM   1750 O  OD2 . ASP A 1 258 ? -12.167 -44.988 -40.483 1.00 35.05  ? 521  ASP A OD2 1 
ATOM   1751 N  N   . VAL A 1 259 ? -7.225  -43.330 -38.421 1.00 24.96  ? 522  VAL A N   1 
ATOM   1752 C  CA  . VAL A 1 259 ? -6.116  -42.346 -38.297 1.00 28.17  ? 522  VAL A CA  1 
ATOM   1753 C  C   . VAL A 1 259 ? -4.788  -43.036 -38.637 1.00 30.63  ? 522  VAL A C   1 
ATOM   1754 O  O   . VAL A 1 259 ? -3.983  -42.445 -39.389 1.00 30.82  ? 522  VAL A O   1 
ATOM   1755 C  CB  . VAL A 1 259 ? -6.106  -41.753 -36.890 1.00 29.21  ? 522  VAL A CB  1 
ATOM   1756 C  CG1 . VAL A 1 259 ? -4.840  -40.942 -36.637 1.00 29.94  ? 522  VAL A CG1 1 
ATOM   1757 C  CG2 . VAL A 1 259 ? -7.350  -40.915 -36.653 1.00 28.62  ? 522  VAL A CG2 1 
ATOM   1758 N  N   . SER A 1 260 ? -4.584  -44.267 -38.182 1.00 29.17  ? 523  SER A N   1 
ATOM   1759 C  CA  . SER A 1 260 ? -3.336  -45.036 -38.390 1.00 30.74  ? 523  SER A CA  1 
ATOM   1760 C  C   . SER A 1 260 ? -3.079  -45.242 -39.887 1.00 31.31  ? 523  SER A C   1 
ATOM   1761 O  O   . SER A 1 260 ? -1.910  -45.368 -40.230 1.00 29.87  ? 523  SER A O   1 
ATOM   1762 C  CB  . SER A 1 260 ? -3.323  -46.373 -37.683 1.00 28.62  ? 523  SER A CB  1 
ATOM   1763 O  OG  . SER A 1 260 ? -3.996  -47.351 -38.462 1.00 32.31  ? 523  SER A OG  1 
ATOM   1764 N  N   . LYS A 1 261 ? -4.104  -45.218 -40.729 1.00 30.47  ? 524  LYS A N   1 
ATOM   1765 C  CA  . LYS A 1 261 ? -3.989  -45.477 -42.189 1.00 35.03  ? 524  LYS A CA  1 
ATOM   1766 C  C   . LYS A 1 261 ? -3.353  -44.281 -42.922 1.00 38.18  ? 524  LYS A C   1 
ATOM   1767 O  O   . LYS A 1 261 ? -2.906  -44.469 -44.071 1.00 37.27  ? 524  LYS A O   1 
ATOM   1768 C  CB  . LYS A 1 261 ? -5.355  -45.741 -42.805 1.00 39.71  ? 524  LYS A CB  1 
ATOM   1769 C  CG  . LYS A 1 261 ? -5.950  -47.073 -42.425 1.00 46.39  ? 524  LYS A CG  1 
ATOM   1770 C  CD  . LYS A 1 261 ? -7.331  -47.225 -42.998 1.00 53.68  ? 524  LYS A CD  1 
ATOM   1771 C  CE  . LYS A 1 261 ? -7.902  -48.583 -42.686 1.00 60.27  ? 524  LYS A CE  1 
ATOM   1772 N  NZ  . LYS A 1 261 ? -9.376  -48.515 -42.781 1.00 75.08  ? 524  LYS A NZ  1 
ATOM   1773 N  N   . LYS A 1 262 ? -3.360  -43.102 -42.310 1.00 33.28  ? 525  LYS A N   1 
ATOM   1774 C  CA  . LYS A 1 262 ? -2.726  -41.885 -42.868 1.00 37.07  ? 525  LYS A CA  1 
ATOM   1775 C  C   . LYS A 1 262 ? -1.219  -42.096 -42.970 1.00 39.66  ? 525  LYS A C   1 
ATOM   1776 O  O   . LYS A 1 262 ? -0.649  -42.725 -42.088 1.00 36.87  ? 525  LYS A O   1 
ATOM   1777 C  CB  . LYS A 1 262 ? -3.045  -40.687 -41.981 1.00 36.50  ? 525  LYS A CB  1 
ATOM   1778 C  CG  . LYS A 1 262 ? -4.550  -40.405 -41.970 1.00 42.14  ? 525  LYS A CG  1 
ATOM   1779 C  CD  . LYS A 1 262 ? -4.946  -38.979 -42.014 1.00 45.28  ? 525  LYS A CD  1 
ATOM   1780 C  CE  . LYS A 1 262 ? -6.381  -38.783 -42.446 1.00 47.00  ? 525  LYS A CE  1 
ATOM   1781 N  NZ  . LYS A 1 262 ? -6.479  -37.639 -43.383 1.00 51.56  ? 525  LYS A NZ  1 
ATOM   1782 N  N   . GLU A 1 263 ? -0.582  -41.519 -43.978 1.00 38.61  ? 526  GLU A N   1 
ATOM   1783 C  CA  . GLU A 1 263 ? 0.896   -41.465 -43.994 1.00 38.89  ? 526  GLU A CA  1 
ATOM   1784 C  C   . GLU A 1 263 ? 1.315   -40.505 -42.873 1.00 34.30  ? 526  GLU A C   1 
ATOM   1785 O  O   . GLU A 1 263 ? 0.665   -39.490 -42.691 1.00 37.23  ? 526  GLU A O   1 
ATOM   1786 C  CB  . GLU A 1 263 ? 1.385   -41.041 -45.378 1.00 46.44  ? 526  GLU A CB  1 
ATOM   1787 C  CG  . GLU A 1 263 ? 1.027   -42.025 -46.484 1.00 51.01  ? 526  GLU A CG  1 
ATOM   1788 C  CD  . GLU A 1 263 ? 1.753   -43.366 -46.422 1.00 61.77  ? 526  GLU A CD  1 
ATOM   1789 O  OE1 . GLU A 1 263 ? 2.929   -43.383 -45.992 1.00 61.20  ? 526  GLU A OE1 1 
ATOM   1790 O  OE2 . GLU A 1 263 ? 1.125   -44.406 -46.769 1.00 63.01  ? 526  GLU A OE2 1 
ATOM   1791 N  N   . GLY A 1 264 ? 2.336   -40.844 -42.121 1.00 32.10  ? 527  GLY A N   1 
ATOM   1792 C  CA  . GLY A 1 264 ? 2.937   -39.865 -41.213 1.00 35.04  ? 527  GLY A CA  1 
ATOM   1793 C  C   . GLY A 1 264 ? 3.797   -40.519 -40.177 1.00 35.10  ? 527  GLY A C   1 
ATOM   1794 O  O   . GLY A 1 264 ? 4.279   -41.631 -40.414 1.00 35.89  ? 527  GLY A O   1 
ATOM   1795 N  N   . GLY A 1 265 ? 4.005   -39.839 -39.060 1.00 35.85  ? 528  GLY A N   1 
ATOM   1796 C  CA  . GLY A 1 265 ? 4.922   -40.342 -38.027 1.00 37.29  ? 528  GLY A CA  1 
ATOM   1797 C  C   . GLY A 1 265 ? 4.234   -41.291 -37.036 1.00 40.27  ? 528  GLY A C   1 
ATOM   1798 O  O   . GLY A 1 265 ? 3.245   -41.979 -37.410 1.00 37.54  ? 528  GLY A O   1 
ATOM   1799 N  N   . ALA A 1 266 ? 4.796   -41.387 -35.841 1.00 31.95  ? 529  ALA A N   1 
ATOM   1800 C  CA  . ALA A 1 266 ? 4.237   -42.133 -34.697 1.00 30.51  ? 529  ALA A CA  1 
ATOM   1801 C  C   . ALA A 1 266 ? 2.866   -41.557 -34.352 1.00 29.10  ? 529  ALA A C   1 
ATOM   1802 O  O   . ALA A 1 266 ? 2.538   -40.457 -34.812 1.00 27.00  ? 529  ALA A O   1 
ATOM   1803 C  CB  . ALA A 1 266 ? 5.183   -42.020 -33.526 1.00 29.12  ? 529  ALA A CB  1 
ATOM   1804 N  N   . MET A 1 267 ? 2.078   -42.272 -33.547 1.00 26.37  ? 530  MET A N   1 
ATOM   1805 C  CA  . MET A 1 267 ? 0.872   -41.698 -32.905 1.00 26.25  ? 530  MET A CA  1 
ATOM   1806 C  C   . MET A 1 267 ? 1.248   -41.174 -31.518 1.00 27.20  ? 530  MET A C   1 
ATOM   1807 O  O   . MET A 1 267 ? 1.814   -41.938 -30.700 1.00 32.55  ? 530  MET A O   1 
ATOM   1808 C  CB  . MET A 1 267 ? -0.234  -42.781 -32.859 1.00 27.97  ? 530  MET A CB  1 
ATOM   1809 C  CG  . MET A 1 267 ? -0.675  -43.182 -34.237 1.00 28.84  ? 530  MET A CG  1 
ATOM   1810 S  SD  . MET A 1 267 ? -2.014  -44.442 -34.423 1.00 38.11  ? 530  MET A SD  1 
ATOM   1811 C  CE  . MET A 1 267 ? -3.466  -43.537 -33.941 1.00 37.13  ? 530  MET A CE  1 
ATOM   1812 N  N   . TYR A 1 268 ? 0.925   -39.910 -31.237 1.00 22.24  ? 531  TYR A N   1 
ATOM   1813 C  CA  . TYR A 1 268 ? 1.232   -39.243 -29.972 1.00 24.10  ? 531  TYR A CA  1 
ATOM   1814 C  C   . TYR A 1 268 ? -0.050  -39.138 -29.171 1.00 24.51  ? 531  TYR A C   1 
ATOM   1815 O  O   . TYR A 1 268 ? -1.112  -38.733 -29.751 1.00 26.52  ? 531  TYR A O   1 
ATOM   1816 C  CB  . TYR A 1 268 ? 1.893   -37.905 -30.268 1.00 23.71  ? 531  TYR A CB  1 
ATOM   1817 C  CG  . TYR A 1 268 ? 3.216   -38.066 -30.965 1.00 26.91  ? 531  TYR A CG  1 
ATOM   1818 C  CD1 . TYR A 1 268 ? 3.297   -38.227 -32.335 1.00 25.54  ? 531  TYR A CD1 1 
ATOM   1819 C  CD2 . TYR A 1 268 ? 4.384   -38.201 -30.229 1.00 28.13  ? 531  TYR A CD2 1 
ATOM   1820 C  CE1 . TYR A 1 268 ? 4.522   -38.422 -32.962 1.00 28.59  ? 531  TYR A CE1 1 
ATOM   1821 C  CE2 . TYR A 1 268 ? 5.610   -38.373 -30.850 1.00 28.66  ? 531  TYR A CE2 1 
ATOM   1822 C  CZ  . TYR A 1 268 ? 5.686   -38.517 -32.210 1.00 31.73  ? 531  TYR A CZ  1 
ATOM   1823 O  OH  . TYR A 1 268 ? 6.901   -38.745 -32.836 1.00 29.10  ? 531  TYR A OH  1 
ATOM   1824 N  N   . ALA A 1 269 ? 0.041   -39.418 -27.884 1.00 23.56  ? 532  ALA A N   1 
ATOM   1825 C  CA  . ALA A 1 269 ? -1.113  -39.393 -26.970 1.00 24.20  ? 532  ALA A CA  1 
ATOM   1826 C  C   . ALA A 1 269 ? -0.642  -38.820 -25.653 1.00 28.71  ? 532  ALA A C   1 
ATOM   1827 O  O   . ALA A 1 269 ? -0.574  -39.558 -24.651 1.00 29.31  ? 532  ALA A O   1 
ATOM   1828 C  CB  . ALA A 1 269 ? -1.714  -40.782 -26.874 1.00 25.51  ? 532  ALA A CB  1 
ATOM   1829 N  N   . ASP A 1 270 ? -0.214  -37.571 -25.671 1.00 26.84  ? 533  ASP A N   1 
ATOM   1830 C  CA  . ASP A 1 270 ? 0.349   -36.932 -24.468 1.00 27.46  ? 533  ASP A CA  1 
ATOM   1831 C  C   . ASP A 1 270 ? -0.806  -36.408 -23.636 1.00 32.84  ? 533  ASP A C   1 
ATOM   1832 O  O   . ASP A 1 270 ? -1.601  -35.643 -24.145 1.00 31.13  ? 533  ASP A O   1 
ATOM   1833 C  CB  . ASP A 1 270 ? 1.255   -35.751 -24.847 1.00 30.08  ? 533  ASP A CB  1 
ATOM   1834 C  CG  . ASP A 1 270 ? 2.543   -36.161 -25.524 1.00 33.53  ? 533  ASP A CG  1 
ATOM   1835 O  OD1 . ASP A 1 270 ? 2.895   -37.349 -25.406 1.00 33.13  ? 533  ASP A OD1 1 
ATOM   1836 O  OD2 . ASP A 1 270 ? 3.147   -35.314 -26.222 1.00 33.10  ? 533  ASP A OD2 1 
ATOM   1837 N  N   . ASP A 1 271 ? -0.892  -36.812 -22.370 0.50 33.23  ? 534  ASP A N   1 
ATOM   1838 C  CA  . ASP A 1 271 ? -1.894  -36.279 -21.410 0.50 34.90  ? 534  ASP A CA  1 
ATOM   1839 C  C   . ASP A 1 271 ? -1.338  -34.977 -20.823 0.50 33.69  ? 534  ASP A C   1 
ATOM   1840 O  O   . ASP A 1 271 ? -0.166  -34.976 -20.402 0.50 34.68  ? 534  ASP A O   1 
ATOM   1841 C  CB  . ASP A 1 271 ? -2.236  -37.308 -20.328 0.50 36.70  ? 534  ASP A CB  1 
ATOM   1842 C  CG  . ASP A 1 271 ? -3.147  -38.429 -20.801 0.50 41.69  ? 534  ASP A CG  1 
ATOM   1843 O  OD1 . ASP A 1 271 ? -4.122  -38.140 -21.551 0.50 40.83  ? 534  ASP A OD1 1 
ATOM   1844 O  OD2 . ASP A 1 271 ? -2.888  -39.586 -20.421 0.50 40.99  ? 534  ASP A OD2 1 
ATOM   1845 N  N   . THR A 1 272 ? -2.118  -33.893 -20.854 0.50 30.03  ? 535  THR A N   1 
ATOM   1846 C  CA  . THR A 1 272 ? -1.832  -32.647 -20.094 0.50 30.13  ? 535  THR A CA  1 
ATOM   1847 C  C   . THR A 1 272 ? -2.048  -32.936 -18.606 0.50 30.61  ? 535  THR A C   1 
ATOM   1848 O  O   . THR A 1 272 ? -2.960  -33.708 -18.288 0.50 31.93  ? 535  THR A O   1 
ATOM   1849 C  CB  . THR A 1 272 ? -2.705  -31.482 -20.570 0.50 31.07  ? 535  THR A CB  1 
ATOM   1850 O  OG1 . THR A 1 272 ? -2.584  -31.387 -21.988 0.50 31.65  ? 535  THR A OG1 1 
ATOM   1851 C  CG2 . THR A 1 272 ? -2.327  -30.159 -19.947 0.50 30.36  ? 535  THR A CG2 1 
ATOM   1852 N  N   . ALA A 1 273 ? -1.231  -32.349 -17.730 0.50 34.30  ? 536  ALA A N   1 
ATOM   1853 C  CA  . ALA A 1 273 ? -1.415  -32.396 -16.262 0.50 34.96  ? 536  ALA A CA  1 
ATOM   1854 C  C   . ALA A 1 273 ? -2.478  -31.363 -15.857 0.50 34.37  ? 536  ALA A C   1 
ATOM   1855 O  O   . ALA A 1 273 ? -2.298  -30.179 -16.191 0.50 33.65  ? 536  ALA A O   1 
ATOM   1856 C  CB  . ALA A 1 273 ? -0.089  -32.153 -15.574 0.50 35.55  ? 536  ALA A CB  1 
ATOM   1857 N  N   . GLY A 1 274 ? -3.561  -31.823 -15.218 0.50 35.47  ? 537  GLY A N   1 
ATOM   1858 C  CA  . GLY A 1 274 ? -4.670  -31.005 -14.678 0.50 34.62  ? 537  GLY A CA  1 
ATOM   1859 C  C   . GLY A 1 274 ? -5.161  -29.967 -15.676 0.50 34.60  ? 537  GLY A C   1 
ATOM   1860 O  O   . GLY A 1 274 ? -5.217  -28.769 -15.314 0.50 33.25  ? 537  GLY A O   1 
ATOM   1861 N  N   . TRP A 1 275 ? -5.541  -30.418 -16.875 0.50 32.86  ? 538  TRP A N   1 
ATOM   1862 C  CA  . TRP A 1 275 ? -5.928  -29.578 -18.043 0.50 31.73  ? 538  TRP A CA  1 
ATOM   1863 C  C   . TRP A 1 275 ? -6.774  -28.364 -17.622 0.50 31.70  ? 538  TRP A C   1 
ATOM   1864 O  O   . TRP A 1 275 ? -6.485  -27.242 -18.110 0.50 31.24  ? 538  TRP A O   1 
ATOM   1865 C  CB  . TRP A 1 275 ? -6.665  -30.425 -19.084 0.50 30.60  ? 538  TRP A CB  1 
ATOM   1866 C  CG  . TRP A 1 275 ? -7.290  -29.598 -20.163 0.50 30.57  ? 538  TRP A CG  1 
ATOM   1867 C  CD1 . TRP A 1 275 ? -8.502  -28.975 -20.118 0.50 31.41  ? 538  TRP A CD1 1 
ATOM   1868 C  CD2 . TRP A 1 275 ? -6.732  -29.295 -21.452 0.50 29.12  ? 538  TRP A CD2 1 
ATOM   1869 N  NE1 . TRP A 1 275 ? -8.734  -28.310 -21.291 0.50 31.86  ? 538  TRP A NE1 1 
ATOM   1870 C  CE2 . TRP A 1 275 ? -7.668  -28.487 -22.128 0.50 30.26  ? 538  TRP A CE2 1 
ATOM   1871 C  CE3 . TRP A 1 275 ? -5.547  -29.636 -22.106 0.50 29.56  ? 538  TRP A CE3 1 
ATOM   1872 C  CZ2 . TRP A 1 275 ? -7.447  -28.005 -23.415 0.50 29.89  ? 538  TRP A CZ2 1 
ATOM   1873 C  CZ3 . TRP A 1 275 ? -5.330  -29.163 -23.379 0.50 30.63  ? 538  TRP A CZ3 1 
ATOM   1874 C  CH2 . TRP A 1 275 ? -6.271  -28.362 -24.026 0.50 31.78  ? 538  TRP A CH2 1 
ATOM   1875 N  N   . ASP A 1 276 ? -7.802  -28.577 -16.805 0.50 32.72  ? 539  ASP A N   1 
ATOM   1876 C  CA  . ASP A 1 276 ? -8.815  -27.543 -16.445 0.50 33.91  ? 539  ASP A CA  1 
ATOM   1877 C  C   . ASP A 1 276 ? -8.122  -26.399 -15.698 0.50 37.59  ? 539  ASP A C   1 
ATOM   1878 O  O   . ASP A 1 276 ? -8.497  -25.226 -15.926 0.50 37.14  ? 539  ASP A O   1 
ATOM   1879 C  CB  . ASP A 1 276 ? -9.957  -28.138 -15.622 0.50 32.72  ? 539  ASP A CB  1 
ATOM   1880 C  CG  . ASP A 1 276 ? -11.026 -28.806 -16.465 0.50 32.02  ? 539  ASP A CG  1 
ATOM   1881 O  OD1 . ASP A 1 276 ? -10.865 -28.828 -17.701 0.50 30.36  ? 539  ASP A OD1 1 
ATOM   1882 O  OD2 . ASP A 1 276 ? -12.006 -29.309 -15.879 0.50 33.15  ? 539  ASP A OD2 1 
ATOM   1883 N  N   . THR A 1 277 ? -7.124  -26.718 -14.869 1.00 39.38  ? 540  THR A N   1 
ATOM   1884 C  CA  . THR A 1 277 ? -6.333  -25.685 -14.145 1.00 41.11  ? 540  THR A CA  1 
ATOM   1885 C  C   . THR A 1 277 ? -5.416  -24.868 -15.066 1.00 43.31  ? 540  THR A C   1 
ATOM   1886 O  O   . THR A 1 277 ? -4.948  -23.835 -14.620 1.00 45.22  ? 540  THR A O   1 
ATOM   1887 C  CB  . THR A 1 277 ? -5.535  -26.299 -12.983 1.00 41.06  ? 540  THR A CB  1 
ATOM   1888 O  OG1 . THR A 1 277 ? -4.498  -27.144 -13.475 1.00 47.86  ? 540  THR A OG1 1 
ATOM   1889 C  CG2 . THR A 1 277 ? -6.414  -27.123 -12.076 1.00 43.92  ? 540  THR A CG2 1 
ATOM   1890 N  N   . ARG A 1 278 ? -5.203  -25.302 -16.317 0.50 40.50  ? 541  ARG A N   1 
ATOM   1891 C  CA  . ARG A 1 278 ? -4.243  -24.676 -17.271 0.50 40.91  ? 541  ARG A CA  1 
ATOM   1892 C  C   . ARG A 1 278 ? -4.968  -23.883 -18.364 0.50 39.66  ? 541  ARG A C   1 
ATOM   1893 O  O   . ARG A 1 278 ? -4.292  -23.495 -19.337 0.50 38.12  ? 541  ARG A O   1 
ATOM   1894 C  CB  . ARG A 1 278 ? -3.377  -25.746 -17.942 0.50 43.99  ? 541  ARG A CB  1 
ATOM   1895 C  CG  . ARG A 1 278 ? -2.716  -26.711 -16.971 0.50 48.19  ? 541  ARG A CG  1 
ATOM   1896 C  CD  . ARG A 1 278 ? -1.786  -26.017 -15.995 0.50 52.81  ? 541  ARG A CD  1 
ATOM   1897 N  NE  . ARG A 1 278 ? -1.031  -26.984 -15.205 0.50 61.31  ? 541  ARG A NE  1 
ATOM   1898 C  CZ  . ARG A 1 278 ? 0.271   -27.220 -15.334 0.50 60.50  ? 541  ARG A CZ  1 
ATOM   1899 N  NH1 . ARG A 1 278 ? 0.988   -26.547 -16.218 0.50 62.12  ? 541  ARG A NH1 1 
ATOM   1900 N  NH2 . ARG A 1 278 ? 0.855   -28.119 -14.563 0.50 61.61  ? 541  ARG A NH2 1 
ATOM   1901 N  N   . ILE A 1 279 ? -6.284  -23.679 -18.240 0.50 37.84  ? 542  ILE A N   1 
ATOM   1902 C  CA  . ILE A 1 279 ? -7.083  -22.850 -19.192 0.50 39.30  ? 542  ILE A CA  1 
ATOM   1903 C  C   . ILE A 1 279 ? -6.784  -21.370 -18.908 0.50 37.97  ? 542  ILE A C   1 
ATOM   1904 O  O   . ILE A 1 279 ? -7.115  -20.897 -17.819 0.50 38.01  ? 542  ILE A O   1 
ATOM   1905 C  CB  . ILE A 1 279 ? -8.583  -23.191 -19.077 0.50 39.28  ? 542  ILE A CB  1 
ATOM   1906 C  CG1 . ILE A 1 279 ? -8.857  -24.627 -19.531 0.50 40.67  ? 542  ILE A CG1 1 
ATOM   1907 C  CG2 . ILE A 1 279 ? -9.441  -22.193 -19.845 0.50 39.48  ? 542  ILE A CG2 1 
ATOM   1908 C  CD1 . ILE A 1 279 ? -8.783  -24.807 -21.025 0.50 40.22  ? 542  ILE A CD1 1 
ATOM   1909 N  N   . THR A 1 280 ? -6.151  -20.674 -19.853 0.50 41.12  ? 543  THR A N   1 
ATOM   1910 C  CA  . THR A 1 280 ? -5.718  -19.257 -19.705 0.50 41.58  ? 543  THR A CA  1 
ATOM   1911 C  C   . THR A 1 280 ? -6.894  -18.319 -19.995 0.50 41.89  ? 543  THR A C   1 
ATOM   1912 O  O   . THR A 1 280 ? -7.841  -18.744 -20.704 0.50 38.07  ? 543  THR A O   1 
ATOM   1913 C  CB  . THR A 1 280 ? -4.536  -18.959 -20.630 0.50 41.10  ? 543  THR A CB  1 
ATOM   1914 O  OG1 . THR A 1 280 ? -4.989  -19.115 -21.975 0.50 41.56  ? 543  THR A OG1 1 
ATOM   1915 C  CG2 . THR A 1 280 ? -3.353  -19.864 -20.373 0.50 43.98  ? 543  THR A CG2 1 
ATOM   1916 N  N   . LEU A 1 281 ? -6.818  -17.069 -19.523 1.00 43.25  ? 544  LEU A N   1 
ATOM   1917 C  CA  . LEU A 1 281 ? -7.859  -16.061 -19.843 1.00 43.04  ? 544  LEU A CA  1 
ATOM   1918 C  C   . LEU A 1 281 ? -7.858  -15.901 -21.367 1.00 37.19  ? 544  LEU A C   1 
ATOM   1919 O  O   . LEU A 1 281 ? -8.912  -15.672 -21.947 1.00 37.97  ? 544  LEU A O   1 
ATOM   1920 C  CB  . LEU A 1 281 ? -7.555  -14.750 -19.105 1.00 57.63  ? 544  LEU A CB  1 
ATOM   1921 C  CG  . LEU A 1 281 ? -8.478  -13.577 -19.439 1.00 64.50  ? 544  LEU A CG  1 
ATOM   1922 C  CD1 . LEU A 1 281 ? -9.961  -13.974 -19.369 1.00 63.47  ? 544  LEU A CD1 1 
ATOM   1923 C  CD2 . LEU A 1 281 ? -8.183  -12.401 -18.517 1.00 65.51  ? 544  LEU A CD2 1 
ATOM   1924 N  N   . GLU A 1 282 ? -6.713  -16.118 -22.016 1.00 38.90  ? 545  GLU A N   1 
ATOM   1925 C  CA  . GLU A 1 282 ? -6.619  -16.044 -23.497 1.00 38.77  ? 545  GLU A CA  1 
ATOM   1926 C  C   . GLU A 1 282 ? -7.489  -17.156 -24.118 1.00 41.79  ? 545  GLU A C   1 
ATOM   1927 O  O   . GLU A 1 282 ? -8.242  -16.895 -25.112 1.00 38.10  ? 545  GLU A O   1 
ATOM   1928 C  CB  . GLU A 1 282 ? -5.139  -16.096 -23.856 1.00 50.10  ? 545  GLU A CB  1 
ATOM   1929 C  CG  . GLU A 1 282 ? -4.788  -15.360 -25.126 1.00 61.69  ? 545  GLU A CG  1 
ATOM   1930 C  CD  . GLU A 1 282 ? -5.113  -13.873 -25.152 1.00 61.73  ? 545  GLU A CD  1 
ATOM   1931 O  OE1 . GLU A 1 282 ? -5.177  -13.248 -24.067 1.00 62.64  ? 545  GLU A OE1 1 
ATOM   1932 O  OE2 . GLU A 1 282 ? -5.316  -13.357 -26.271 1.00 63.60  ? 545  GLU A OE2 1 
ATOM   1933 N  N   . ASP A 1 283 ? -7.422  -18.368 -23.563 0.50 39.07  ? 546  ASP A N   1 
ATOM   1934 C  CA  . ASP A 1 283 ? -8.255  -19.518 -24.016 0.50 38.01  ? 546  ASP A CA  1 
ATOM   1935 C  C   . ASP A 1 283 ? -9.745  -19.183 -23.827 0.50 37.41  ? 546  ASP A C   1 
ATOM   1936 O  O   . ASP A 1 283 ? -10.528 -19.442 -24.763 0.50 38.35  ? 546  ASP A O   1 
ATOM   1937 C  CB  . ASP A 1 283 ? -7.856  -20.805 -23.291 0.50 36.30  ? 546  ASP A CB  1 
ATOM   1938 C  CG  . ASP A 1 283 ? -6.488  -21.361 -23.678 0.50 35.95  ? 546  ASP A CG  1 
ATOM   1939 O  OD1 . ASP A 1 283 ? -6.092  -21.215 -24.864 0.50 34.22  ? 546  ASP A OD1 1 
ATOM   1940 O  OD2 . ASP A 1 283 ? -5.833  -21.953 -22.792 0.50 35.14  ? 546  ASP A OD2 1 
ATOM   1941 N  N   . LEU A 1 284 ? -10.136 -18.624 -22.676 1.00 38.36  ? 547  LEU A N   1 
ATOM   1942 C  CA  . LEU A 1 284 ? -11.559 -18.223 -22.437 1.00 38.52  ? 547  LEU A CA  1 
ATOM   1943 C  C   . LEU A 1 284 ? -12.073 -17.172 -23.451 1.00 39.99  ? 547  LEU A C   1 
ATOM   1944 O  O   . LEU A 1 284 ? -13.236 -17.265 -23.870 1.00 42.50  ? 547  LEU A O   1 
ATOM   1945 C  CB  . LEU A 1 284 ? -11.684 -17.755 -20.991 1.00 41.83  ? 547  LEU A CB  1 
ATOM   1946 C  CG  . LEU A 1 284 ? -11.417 -18.830 -19.934 1.00 41.15  ? 547  LEU A CG  1 
ATOM   1947 C  CD1 . LEU A 1 284 ? -11.324 -18.195 -18.558 1.00 52.03  ? 547  LEU A CD1 1 
ATOM   1948 C  CD2 . LEU A 1 284 ? -12.477 -19.931 -19.914 1.00 40.58  ? 547  LEU A CD2 1 
ATOM   1949 N  N   . LYS A 1 285 ? -11.216 -16.204 -23.803 0.50 42.03  ? 548  LYS A N   1 
ATOM   1950 C  CA  . LYS A 1 285 ? -11.469 -15.152 -24.827 0.50 42.15  ? 548  LYS A CA  1 
ATOM   1951 C  C   . LYS A 1 285 ? -11.671 -15.813 -26.193 0.50 40.39  ? 548  LYS A C   1 
ATOM   1952 O  O   . LYS A 1 285 ? -12.663 -15.479 -26.870 0.50 37.18  ? 548  LYS A O   1 
ATOM   1953 C  CB  . LYS A 1 285 ? -10.305 -14.156 -24.896 0.50 45.84  ? 548  LYS A CB  1 
ATOM   1954 C  CG  . LYS A 1 285 ? -10.309 -13.066 -23.835 0.50 48.82  ? 548  LYS A CG  1 
ATOM   1955 C  CD  . LYS A 1 285 ? -9.283  -11.975 -24.092 0.50 53.18  ? 548  LYS A CD  1 
ATOM   1956 C  CE  . LYS A 1 285 ? -9.598  -10.671 -23.386 0.50 55.90  ? 548  LYS A CE  1 
ATOM   1957 N  NZ  . LYS A 1 285 ? -10.867 -10.070 -23.866 0.50 55.56  ? 548  LYS A NZ  1 
ATOM   1958 N  N   . ASN A 1 286 ? -10.775 -16.732 -26.570 1.00 35.86  ? 549  ASN A N   1 
ATOM   1959 C  CA  . ASN A 1 286 ? -10.881 -17.442 -27.867 1.00 35.88  ? 549  ASN A CA  1 
ATOM   1960 C  C   . ASN A 1 286 ? -12.154 -18.306 -27.911 1.00 30.28  ? 549  ASN A C   1 
ATOM   1961 O  O   . ASN A 1 286 ? -12.786 -18.390 -28.979 1.00 34.27  ? 549  ASN A O   1 
ATOM   1962 C  CB  . ASN A 1 286 ? -9.611  -18.250 -28.116 1.00 38.26  ? 549  ASN A CB  1 
ATOM   1963 C  CG  . ASN A 1 286 ? -8.427  -17.333 -28.353 1.00 44.66  ? 549  ASN A CG  1 
ATOM   1964 O  OD1 . ASN A 1 286 ? -8.566  -16.274 -28.967 1.00 42.54  ? 549  ASN A OD1 1 
ATOM   1965 N  ND2 . ASN A 1 286 ? -7.257  -17.750 -27.920 1.00 39.86  ? 549  ASN A ND2 1 
ATOM   1966 N  N   . GLU A 1 287 ? -12.497 -18.969 -26.820 1.00 30.44  ? 550  GLU A N   1 
ATOM   1967 C  CA  . GLU A 1 287 ? -13.750 -19.770 -26.726 1.00 33.15  ? 550  GLU A CA  1 
ATOM   1968 C  C   . GLU A 1 287 ? -14.991 -18.843 -26.901 1.00 35.18  ? 550  GLU A C   1 
ATOM   1969 O  O   . GLU A 1 287 ? -15.957 -19.229 -27.607 1.00 33.69  ? 550  GLU A O   1 
ATOM   1970 C  CB  . GLU A 1 287 ? -13.736 -20.502 -25.394 1.00 32.75  ? 550  GLU A CB  1 
ATOM   1971 C  CG  . GLU A 1 287 ? -12.758 -21.682 -25.383 1.00 33.48  ? 550  GLU A CG  1 
ATOM   1972 C  CD  . GLU A 1 287 ? -12.483 -22.214 -23.993 1.00 37.89  ? 550  GLU A CD  1 
ATOM   1973 O  OE1 . GLU A 1 287 ? -13.189 -21.787 -23.029 1.00 40.77  ? 550  GLU A OE1 1 
ATOM   1974 O  OE2 . GLU A 1 287 ? -11.559 -23.079 -23.843 1.00 39.35  ? 550  GLU A OE2 1 
ATOM   1975 N  N   . GLU A 1 288 ? -14.934 -17.648 -26.302 0.50 37.49  ? 551  GLU A N   1 
ATOM   1976 C  CA  . GLU A 1 288 ? -16.014 -16.618 -26.336 0.50 37.37  ? 551  GLU A CA  1 
ATOM   1977 C  C   . GLU A 1 288 ? -16.342 -16.220 -27.778 0.50 37.67  ? 551  GLU A C   1 
ATOM   1978 O  O   . GLU A 1 288 ? -17.497 -15.823 -28.024 0.50 40.98  ? 551  GLU A O   1 
ATOM   1979 C  CB  . GLU A 1 288 ? -15.591 -15.386 -25.534 0.50 40.87  ? 551  GLU A CB  1 
ATOM   1980 C  CG  . GLU A 1 288 ? -16.745 -14.464 -25.176 0.50 43.65  ? 551  GLU A CG  1 
ATOM   1981 C  CD  . GLU A 1 288 ? -17.030 -13.357 -26.179 0.50 46.50  ? 551  GLU A CD  1 
ATOM   1982 O  OE1 . GLU A 1 288 ? -16.119 -13.030 -26.971 0.50 46.94  ? 551  GLU A OE1 1 
ATOM   1983 O  OE2 . GLU A 1 288 ? -18.159 -12.810 -26.151 0.50 48.00  ? 551  GLU A OE2 1 
ATOM   1984 N  N   . MET A 1 289 ? -15.380 -16.329 -28.699 1.00 35.89  ? 552  MET A N   1 
ATOM   1985 C  CA  . MET A 1 289 ? -15.607 -15.972 -30.124 1.00 38.01  ? 552  MET A CA  1 
ATOM   1986 C  C   . MET A 1 289 ? -16.714 -16.811 -30.769 1.00 39.70  ? 552  MET A C   1 
ATOM   1987 O  O   . MET A 1 289 ? -17.166 -16.438 -31.888 1.00 41.18  ? 552  MET A O   1 
ATOM   1988 C  CB  . MET A 1 289 ? -14.317 -16.048 -30.945 1.00 39.58  ? 552  MET A CB  1 
ATOM   1989 C  CG  . MET A 1 289 ? -13.284 -15.051 -30.452 1.00 44.64  ? 552  MET A CG  1 
ATOM   1990 S  SD  . MET A 1 289 ? -12.066 -14.609 -31.739 1.00 53.15  ? 552  MET A SD  1 
ATOM   1991 C  CE  . MET A 1 289 ? -11.321 -16.207 -32.025 1.00 46.50  ? 552  MET A CE  1 
ATOM   1992 N  N   . VAL A 1 290 ? -17.199 -17.886 -30.141 1.00 35.15  ? 553  VAL A N   1 
ATOM   1993 C  CA  . VAL A 1 290 ? -18.390 -18.569 -30.727 1.00 34.96  ? 553  VAL A CA  1 
ATOM   1994 C  C   . VAL A 1 290 ? -19.562 -17.553 -30.812 1.00 30.60  ? 553  VAL A C   1 
ATOM   1995 O  O   . VAL A 1 290 ? -20.378 -17.688 -31.737 1.00 39.22  ? 553  VAL A O   1 
ATOM   1996 C  CB  . VAL A 1 290 ? -18.787 -19.845 -29.966 1.00 28.94  ? 553  VAL A CB  1 
ATOM   1997 C  CG1 . VAL A 1 290 ? -19.280 -19.578 -28.559 1.00 31.75  ? 553  VAL A CG1 1 
ATOM   1998 C  CG2 . VAL A 1 290 ? -19.813 -20.614 -30.755 1.00 30.26  ? 553  VAL A CG2 1 
ATOM   1999 N  N   . THR A 1 291 ? -19.649 -16.606 -29.891 1.00 34.91  ? 554  THR A N   1 
ATOM   2000 C  CA  . THR A 1 291 ? -20.742 -15.566 -29.883 1.00 38.78  ? 554  THR A CA  1 
ATOM   2001 C  C   . THR A 1 291 ? -20.736 -14.692 -31.151 1.00 42.96  ? 554  THR A C   1 
ATOM   2002 O  O   . THR A 1 291 ? -21.831 -14.140 -31.477 1.00 45.43  ? 554  THR A O   1 
ATOM   2003 C  CB  . THR A 1 291 ? -20.647 -14.626 -28.684 1.00 35.79  ? 554  THR A CB  1 
ATOM   2004 O  OG1 . THR A 1 291 ? -19.387 -13.969 -28.809 1.00 36.35  ? 554  THR A OG1 1 
ATOM   2005 C  CG2 . THR A 1 291 ? -20.758 -15.316 -27.350 1.00 35.37  ? 554  THR A CG2 1 
ATOM   2006 N  N   . ASN A 1 292 ? -19.594 -14.560 -31.836 1.00 42.69  ? 555  ASN A N   1 
ATOM   2007 C  CA  . ASN A 1 292 ? -19.476 -13.843 -33.135 1.00 45.54  ? 555  ASN A CA  1 
ATOM   2008 C  C   . ASN A 1 292 ? -20.399 -14.469 -34.178 1.00 52.43  ? 555  ASN A C   1 
ATOM   2009 O  O   . ASN A 1 292 ? -20.569 -13.859 -35.247 1.00 51.25  ? 555  ASN A O   1 
ATOM   2010 C  CB  . ASN A 1 292 ? -18.080 -13.894 -33.760 1.00 44.94  ? 555  ASN A CB  1 
ATOM   2011 C  CG  . ASN A 1 292 ? -17.047 -13.159 -32.940 1.00 44.54  ? 555  ASN A CG  1 
ATOM   2012 O  OD1 . ASN A 1 292 ? -17.376 -12.499 -31.957 1.00 50.26  ? 555  ASN A OD1 1 
ATOM   2013 N  ND2 . ASN A 1 292 ? -15.789 -13.336 -33.290 1.00 47.02  ? 555  ASN A ND2 1 
ATOM   2014 N  N   . HIS A 1 293 ? -20.892 -15.682 -33.932 1.00 44.15  ? 556  HIS A N   1 
ATOM   2015 C  CA  . HIS A 1 293 ? -21.684 -16.464 -34.909 1.00 45.04  ? 556  HIS A CA  1 
ATOM   2016 C  C   . HIS A 1 293 ? -23.168 -16.403 -34.547 1.00 36.73  ? 556  HIS A C   1 
ATOM   2017 O  O   . HIS A 1 293 ? -23.945 -17.090 -35.182 1.00 40.79  ? 556  HIS A O   1 
ATOM   2018 C  CB  . HIS A 1 293 ? -21.127 -17.894 -34.976 1.00 43.35  ? 556  HIS A CB  1 
ATOM   2019 C  CG  . HIS A 1 293 ? -19.748 -17.921 -35.538 1.00 45.88  ? 556  HIS A CG  1 
ATOM   2020 N  ND1 . HIS A 1 293 ? -19.517 -18.087 -36.891 1.00 49.84  ? 556  HIS A ND1 1 
ATOM   2021 C  CD2 . HIS A 1 293 ? -18.532 -17.764 -34.955 1.00 47.26  ? 556  HIS A CD2 1 
ATOM   2022 C  CE1 . HIS A 1 293 ? -18.221 -18.033 -37.118 1.00 48.15  ? 556  HIS A CE1 1 
ATOM   2023 N  NE2 . HIS A 1 293 ? -17.600 -17.825 -35.958 1.00 43.36  ? 556  HIS A NE2 1 
ATOM   2024 N  N   . MET A 1 294 ? -23.499 -15.704 -33.470 1.00 38.38  ? 557  MET A N   1 
ATOM   2025 C  CA  . MET A 1 294 ? -24.852 -15.664 -32.885 1.00 38.60  ? 557  MET A CA  1 
ATOM   2026 C  C   . MET A 1 294 ? -25.511 -14.331 -33.276 1.00 44.99  ? 557  MET A C   1 
ATOM   2027 O  O   . MET A 1 294 ? -24.868 -13.528 -33.921 1.00 41.98  ? 557  MET A O   1 
ATOM   2028 C  CB  . MET A 1 294 ? -24.777 -15.769 -31.369 1.00 39.86  ? 557  MET A CB  1 
ATOM   2029 C  CG  . MET A 1 294 ? -24.202 -17.127 -30.903 1.00 38.78  ? 557  MET A CG  1 
ATOM   2030 S  SD  . MET A 1 294 ? -24.146 -17.154 -29.141 1.00 36.97  ? 557  MET A SD  1 
ATOM   2031 C  CE  . MET A 1 294 ? -23.217 -18.675 -28.874 1.00 43.44  ? 557  MET A CE  1 
ATOM   2032 N  N   . GLU A 1 295 ? -26.762 -14.141 -32.898 1.00 49.76  ? 558  GLU A N   1 
ATOM   2033 C  CA  . GLU A 1 295 ? -27.519 -12.901 -33.188 1.00 53.22  ? 558  GLU A CA  1 
ATOM   2034 C  C   . GLU A 1 295 ? -28.562 -12.692 -32.105 1.00 53.30  ? 558  GLU A C   1 
ATOM   2035 O  O   . GLU A 1 295 ? -28.881 -13.660 -31.374 1.00 47.40  ? 558  GLU A O   1 
ATOM   2036 C  CB  . GLU A 1 295 ? -28.162 -13.001 -34.565 1.00 51.79  ? 558  GLU A CB  1 
ATOM   2037 C  CG  . GLU A 1 295 ? -29.262 -14.024 -34.665 1.00 53.29  ? 558  GLU A CG  1 
ATOM   2038 C  CD  . GLU A 1 295 ? -29.768 -14.232 -36.082 1.00 68.36  ? 558  GLU A CD  1 
ATOM   2039 O  OE1 . GLU A 1 295 ? -28.940 -14.237 -37.046 1.00 72.60  ? 558  GLU A OE1 1 
ATOM   2040 O  OE2 . GLU A 1 295 ? -30.997 -14.385 -36.224 1.00 71.62  ? 558  GLU A OE2 1 
ATOM   2041 N  N   . GLY A 1 296 ? -29.075 -11.461 -32.047 1.00 59.28  ? 559  GLY A N   1 
ATOM   2042 C  CA  . GLY A 1 296 ? -30.200 -11.062 -31.193 1.00 51.37  ? 559  GLY A CA  1 
ATOM   2043 C  C   . GLY A 1 296 ? -29.907 -11.327 -29.732 1.00 53.52  ? 559  GLY A C   1 
ATOM   2044 O  O   . GLY A 1 296 ? -28.731 -11.135 -29.298 1.00 52.40  ? 559  GLY A O   1 
ATOM   2045 N  N   . GLU A 1 297 ? -30.950 -11.791 -29.039 1.00 48.29  ? 560  GLU A N   1 
ATOM   2046 C  CA  . GLU A 1 297 ? -30.972 -12.175 -27.616 1.00 55.19  ? 560  GLU A CA  1 
ATOM   2047 C  C   . GLU A 1 297 ? -29.832 -13.175 -27.357 1.00 56.54  ? 560  GLU A C   1 
ATOM   2048 O  O   . GLU A 1 297 ? -28.970 -12.912 -26.495 1.00 54.33  ? 560  GLU A O   1 
ATOM   2049 C  CB  . GLU A 1 297 ? -32.325 -12.821 -27.328 1.00 55.77  ? 560  GLU A CB  1 
ATOM   2050 C  CG  . GLU A 1 297 ? -32.807 -12.650 -25.904 1.00 62.74  ? 560  GLU A CG  1 
ATOM   2051 C  CD  . GLU A 1 297 ? -34.257 -13.053 -25.717 1.00 74.54  ? 560  GLU A CD  1 
ATOM   2052 O  OE1 . GLU A 1 297 ? -34.563 -14.247 -25.925 1.00 79.57  ? 560  GLU A OE1 1 
ATOM   2053 O  OE2 . GLU A 1 297 ? -35.077 -12.173 -25.380 1.00 85.42  ? 560  GLU A OE2 1 
ATOM   2054 N  N   . HIS A 1 298 ? -29.852 -14.284 -28.089 1.00 51.56  ? 561  HIS A N   1 
ATOM   2055 C  CA  . HIS A 1 298 ? -28.934 -15.435 -27.889 1.00 50.53  ? 561  HIS A CA  1 
ATOM   2056 C  C   . HIS A 1 298 ? -27.516 -14.889 -27.718 1.00 44.05  ? 561  HIS A C   1 
ATOM   2057 O  O   . HIS A 1 298 ? -26.897 -15.194 -26.695 1.00 49.34  ? 561  HIS A O   1 
ATOM   2058 C  CB  . HIS A 1 298 ? -29.065 -16.442 -29.030 1.00 48.14  ? 561  HIS A CB  1 
ATOM   2059 C  CG  . HIS A 1 298 ? -28.182 -17.631 -28.824 1.00 48.99  ? 561  HIS A CG  1 
ATOM   2060 N  ND1 . HIS A 1 298 ? -27.688 -18.390 -29.879 1.00 43.34  ? 561  HIS A ND1 1 
ATOM   2061 C  CD2 . HIS A 1 298 ? -27.674 -18.159 -27.685 1.00 43.74  ? 561  HIS A CD2 1 
ATOM   2062 C  CE1 . HIS A 1 298 ? -26.936 -19.359 -29.383 1.00 45.77  ? 561  HIS A CE1 1 
ATOM   2063 N  NE2 . HIS A 1 298 ? -26.915 -19.242 -28.039 1.00 43.84  ? 561  HIS A NE2 1 
ATOM   2064 N  N   . LYS A 1 299 ? -27.063 -14.038 -28.635 1.00 42.08  ? 562  LYS A N   1 
ATOM   2065 C  CA  . LYS A 1 299 ? -25.715 -13.432 -28.612 1.00 48.52  ? 562  LYS A CA  1 
ATOM   2066 C  C   . LYS A 1 299 ? -25.482 -12.744 -27.272 1.00 56.73  ? 562  LYS A C   1 
ATOM   2067 O  O   . LYS A 1 299 ? -24.401 -12.958 -26.682 1.00 56.88  ? 562  LYS A O   1 
ATOM   2068 C  CB  . LYS A 1 299 ? -25.533 -12.482 -29.791 1.00 49.44  ? 562  LYS A CB  1 
ATOM   2069 C  CG  . LYS A 1 299 ? -24.224 -11.715 -29.801 1.00 48.60  ? 562  LYS A CG  1 
ATOM   2070 C  CD  . LYS A 1 299 ? -23.982 -11.090 -31.138 1.00 53.76  ? 562  LYS A CD  1 
ATOM   2071 C  CE  . LYS A 1 299 ? -22.894 -10.045 -31.145 1.00 54.59  ? 562  LYS A CE  1 
ATOM   2072 N  NZ  . LYS A 1 299 ? -21.617 -10.622 -31.604 1.00 59.25  ? 562  LYS A NZ  1 
ATOM   2073 N  N   . LYS A 1 300 ? -26.440 -11.944 -26.793 1.00 58.74  ? 563  LYS A N   1 
ATOM   2074 C  CA  . LYS A 1 300 ? -26.240 -11.148 -25.552 1.00 56.53  ? 563  LYS A CA  1 
ATOM   2075 C  C   . LYS A 1 300 ? -26.189 -12.107 -24.368 1.00 41.65  ? 563  LYS A C   1 
ATOM   2076 O  O   . LYS A 1 300 ? -25.340 -11.901 -23.501 1.00 48.97  ? 563  LYS A O   1 
ATOM   2077 C  CB  . LYS A 1 300 ? -27.351 -10.110 -25.305 1.00 66.78  ? 563  LYS A CB  1 
ATOM   2078 C  CG  . LYS A 1 300 ? -27.429 -8.969  -26.316 1.00 73.28  ? 563  LYS A CG  1 
ATOM   2079 C  CD  . LYS A 1 300 ? -26.158 -8.159  -26.468 1.00 72.77  ? 563  LYS A CD  1 
ATOM   2080 C  CE  . LYS A 1 300 ? -25.953 -7.640  -27.877 1.00 80.48  ? 563  LYS A CE  1 
ATOM   2081 N  NZ  . LYS A 1 300 ? -25.169 -6.383  -27.895 1.00 81.26  ? 563  LYS A NZ  1 
ATOM   2082 N  N   . LEU A 1 301 ? -27.097 -13.083 -24.348 1.00 44.95  ? 564  LEU A N   1 
ATOM   2083 C  CA  . LEU A 1 301 ? -27.198 -14.121 -23.289 1.00 45.25  ? 564  LEU A CA  1 
ATOM   2084 C  C   . LEU A 1 301 ? -25.885 -14.960 -23.222 1.00 49.03  ? 564  LEU A C   1 
ATOM   2085 O  O   . LEU A 1 301 ? -25.399 -15.212 -22.105 1.00 44.03  ? 564  LEU A O   1 
ATOM   2086 C  CB  . LEU A 1 301 ? -28.414 -15.000 -23.588 1.00 48.44  ? 564  LEU A CB  1 
ATOM   2087 C  CG  . LEU A 1 301 ? -29.799 -14.391 -23.295 1.00 49.50  ? 564  LEU A CG  1 
ATOM   2088 C  CD1 . LEU A 1 301 ? -30.892 -15.336 -23.715 1.00 49.43  ? 564  LEU A CD1 1 
ATOM   2089 C  CD2 . LEU A 1 301 ? -29.961 -14.061 -21.815 1.00 51.11  ? 564  LEU A CD2 1 
ATOM   2090 N  N   . ALA A 1 302 ? -25.322 -15.380 -24.360 1.00 45.89  ? 565  ALA A N   1 
ATOM   2091 C  CA  . ALA A 1 302 ? -24.066 -16.179 -24.406 1.00 48.12  ? 565  ALA A CA  1 
ATOM   2092 C  C   . ALA A 1 302 ? -22.897 -15.291 -23.972 1.00 49.02  ? 565  ALA A C   1 
ATOM   2093 O  O   . ALA A 1 302 ? -22.022 -15.765 -23.220 1.00 44.84  ? 565  ALA A O   1 
ATOM   2094 C  CB  . ALA A 1 302 ? -23.843 -16.754 -25.786 1.00 43.42  ? 565  ALA A CB  1 
ATOM   2095 N  N   . GLU A 1 303 ? -22.891 -14.031 -24.417 1.00 49.01  ? 566  GLU A N   1 
ATOM   2096 C  CA  . GLU A 1 303 ? -21.842 -13.047 -24.055 1.00 49.26  ? 566  GLU A CA  1 
ATOM   2097 C  C   . GLU A 1 303 ? -21.807 -12.890 -22.537 1.00 46.00  ? 566  GLU A C   1 
ATOM   2098 O  O   . GLU A 1 303 ? -20.704 -12.796 -22.012 1.00 45.70  ? 566  GLU A O   1 
ATOM   2099 C  CB  . GLU A 1 303 ? -22.077 -11.709 -24.744 1.00 56.68  ? 566  GLU A CB  1 
ATOM   2100 C  CG  . GLU A 1 303 ? -21.657 -11.719 -26.191 1.00 58.75  ? 566  GLU A CG  1 
ATOM   2101 C  CD  . GLU A 1 303 ? -21.918 -10.400 -26.894 1.00 62.37  ? 566  GLU A CD  1 
ATOM   2102 O  OE1 . GLU A 1 303 ? -22.220 -9.430  -26.196 1.00 71.95  ? 566  GLU A OE1 1 
ATOM   2103 O  OE2 . GLU A 1 303 ? -21.794 -10.351 -28.137 1.00 63.35  ? 566  GLU A OE2 1 
ATOM   2104 N  N   . ALA A 1 304 ? -22.965 -12.896 -21.868 1.00 44.00  ? 567  ALA A N   1 
ATOM   2105 C  CA  . ALA A 1 304 ? -23.057 -12.756 -20.397 1.00 48.18  ? 567  ALA A CA  1 
ATOM   2106 C  C   . ALA A 1 304 ? -22.569 -14.035 -19.696 1.00 43.96  ? 567  ALA A C   1 
ATOM   2107 O  O   . ALA A 1 304 ? -21.914 -13.910 -18.669 1.00 41.85  ? 567  ALA A O   1 
ATOM   2108 C  CB  . ALA A 1 304 ? -24.461 -12.397 -19.963 1.00 52.09  ? 567  ALA A CB  1 
ATOM   2109 N  N   . ILE A 1 305 ? -22.904 -15.231 -20.183 1.00 46.99  ? 568  ILE A N   1 
ATOM   2110 C  CA  . ILE A 1 305 ? -22.345 -16.461 -19.558 1.00 47.10  ? 568  ILE A CA  1 
ATOM   2111 C  C   . ILE A 1 305 ? -20.812 -16.334 -19.579 1.00 41.80  ? 568  ILE A C   1 
ATOM   2112 O  O   . ILE A 1 305 ? -20.206 -16.406 -18.502 1.00 42.25  ? 568  ILE A O   1 
ATOM   2113 C  CB  . ILE A 1 305 ? -22.850 -17.757 -20.223 1.00 49.90  ? 568  ILE A CB  1 
ATOM   2114 C  CG1 . ILE A 1 305 ? -24.353 -17.971 -19.998 1.00 48.26  ? 568  ILE A CG1 1 
ATOM   2115 C  CG2 . ILE A 1 305 ? -22.019 -18.958 -19.751 1.00 44.23  ? 568  ILE A CG2 1 
ATOM   2116 C  CD1 . ILE A 1 305 ? -24.762 -18.021 -18.554 1.00 47.07  ? 568  ILE A CD1 1 
ATOM   2117 N  N   . PHE A 1 306 ? -20.195 -16.072 -20.727 1.00 42.36  ? 569  PHE A N   1 
ATOM   2118 C  CA  . PHE A 1 306 ? -18.712 -15.996 -20.851 1.00 44.17  ? 569  PHE A CA  1 
ATOM   2119 C  C   . PHE A 1 306 ? -18.120 -14.907 -19.940 1.00 52.27  ? 569  PHE A C   1 
ATOM   2120 O  O   . PHE A 1 306 ? -17.148 -15.194 -19.226 1.00 44.45  ? 569  PHE A O   1 
ATOM   2121 C  CB  . PHE A 1 306 ? -18.265 -15.771 -22.290 1.00 43.30  ? 569  PHE A CB  1 
ATOM   2122 C  CG  . PHE A 1 306 ? -18.287 -17.021 -23.129 1.00 46.90  ? 569  PHE A CG  1 
ATOM   2123 C  CD1 . PHE A 1 306 ? -17.316 -17.995 -22.973 1.00 47.63  ? 569  PHE A CD1 1 
ATOM   2124 C  CD2 . PHE A 1 306 ? -19.252 -17.207 -24.102 1.00 45.03  ? 569  PHE A CD2 1 
ATOM   2125 C  CE1 . PHE A 1 306 ? -17.342 -19.145 -23.748 1.00 46.65  ? 569  PHE A CE1 1 
ATOM   2126 C  CE2 . PHE A 1 306 ? -19.288 -18.360 -24.866 1.00 45.17  ? 569  PHE A CE2 1 
ATOM   2127 C  CZ  . PHE A 1 306 ? -18.333 -19.332 -24.678 1.00 47.60  ? 569  PHE A CZ  1 
ATOM   2128 N  N   . LYS A 1 307 ? -18.690 -13.693 -19.993 0.50 52.14  ? 570  LYS A N   1 
ATOM   2129 C  CA  . LYS A 1 307 ? -18.205 -12.476 -19.277 0.50 52.52  ? 570  LYS A CA  1 
ATOM   2130 C  C   . LYS A 1 307 ? -18.339 -12.657 -17.761 0.50 48.26  ? 570  LYS A C   1 
ATOM   2131 O  O   . LYS A 1 307 ? -17.340 -12.464 -17.054 0.50 48.28  ? 570  LYS A O   1 
ATOM   2132 C  CB  . LYS A 1 307 ? -19.017 -11.235 -19.673 0.50 58.20  ? 570  LYS A CB  1 
ATOM   2133 C  CG  . LYS A 1 307 ? -18.201 -10.012 -20.073 0.50 61.69  ? 570  LYS A CG  1 
ATOM   2134 C  CD  . LYS A 1 307 ? -18.874 -8.692  -19.740 0.50 63.99  ? 570  LYS A CD  1 
ATOM   2135 C  CE  . LYS A 1 307 ? -18.176 -7.497  -20.358 0.50 66.09  ? 570  LYS A CE  1 
ATOM   2136 N  NZ  . LYS A 1 307 ? -18.360 -7.449  -21.828 0.50 67.69  ? 570  LYS A NZ  1 
ATOM   2137 N  N   . LEU A 1 308 ? -19.538 -13.007 -17.290 0.50 46.51  ? 571  LEU A N   1 
ATOM   2138 C  CA  . LEU A 1 308 ? -19.930 -12.899 -15.861 0.50 46.67  ? 571  LEU A CA  1 
ATOM   2139 C  C   . LEU A 1 308 ? -19.511 -14.151 -15.089 0.50 46.86  ? 571  LEU A C   1 
ATOM   2140 O  O   . LEU A 1 308 ? -19.030 -13.986 -13.947 0.50 45.30  ? 571  LEU A O   1 
ATOM   2141 C  CB  . LEU A 1 308 ? -21.444 -12.676 -15.765 0.50 46.92  ? 571  LEU A CB  1 
ATOM   2142 C  CG  . LEU A 1 308 ? -21.954 -11.381 -16.399 0.50 47.62  ? 571  LEU A CG  1 
ATOM   2143 C  CD1 . LEU A 1 308 ? -23.476 -11.344 -16.407 0.50 47.66  ? 571  LEU A CD1 1 
ATOM   2144 C  CD2 . LEU A 1 308 ? -21.391 -10.161 -15.684 0.50 46.72  ? 571  LEU A CD2 1 
ATOM   2145 N  N   . THR A 1 309 ? -19.710 -15.343 -15.667 0.50 47.29  ? 572  THR A N   1 
ATOM   2146 C  CA  . THR A 1 309 ? -19.626 -16.644 -14.948 0.50 48.03  ? 572  THR A CA  1 
ATOM   2147 C  C   . THR A 1 309 ? -18.408 -17.476 -15.378 0.50 46.04  ? 572  THR A C   1 
ATOM   2148 O  O   . THR A 1 309 ? -18.092 -18.410 -14.638 0.50 45.08  ? 572  THR A O   1 
ATOM   2149 C  CB  . THR A 1 309 ? -20.901 -17.474 -15.134 0.50 50.41  ? 572  THR A CB  1 
ATOM   2150 O  OG1 . THR A 1 309 ? -20.973 -17.912 -16.492 0.50 49.70  ? 572  THR A OG1 1 
ATOM   2151 C  CG2 . THR A 1 309 ? -22.155 -16.707 -14.779 0.50 53.51  ? 572  THR A CG2 1 
ATOM   2152 N  N   . TYR A 1 310 ? -17.792 -17.204 -16.534 1.00 46.53  ? 573  TYR A N   1 
ATOM   2153 C  CA  . TYR A 1 310 ? -16.587 -17.967 -17.002 1.00 51.89  ? 573  TYR A CA  1 
ATOM   2154 C  C   . TYR A 1 310 ? -15.317 -17.143 -16.810 1.00 52.45  ? 573  TYR A C   1 
ATOM   2155 O  O   . TYR A 1 310 ? -14.370 -17.687 -16.206 1.00 53.56  ? 573  TYR A O   1 
ATOM   2156 C  CB  . TYR A 1 310 ? -16.697 -18.437 -18.464 1.00 46.57  ? 573  TYR A CB  1 
ATOM   2157 C  CG  . TYR A 1 310 ? -17.694 -19.534 -18.743 1.00 38.93  ? 573  TYR A CG  1 
ATOM   2158 C  CD1 . TYR A 1 310 ? -18.511 -20.058 -17.767 1.00 39.30  ? 573  TYR A CD1 1 
ATOM   2159 C  CD2 . TYR A 1 310 ? -17.883 -19.985 -20.038 1.00 40.13  ? 573  TYR A CD2 1 
ATOM   2160 C  CE1 . TYR A 1 310 ? -19.441 -21.039 -18.047 1.00 38.33  ? 573  TYR A CE1 1 
ATOM   2161 C  CE2 . TYR A 1 310 ? -18.836 -20.934 -20.343 1.00 37.34  ? 573  TYR A CE2 1 
ATOM   2162 C  CZ  . TYR A 1 310 ? -19.591 -21.486 -19.343 1.00 36.04  ? 573  TYR A CZ  1 
ATOM   2163 O  OH  . TYR A 1 310 ? -20.529 -22.409 -19.671 1.00 40.01  ? 573  TYR A OH  1 
ATOM   2164 N  N   . GLN A 1 311 ? -15.297 -15.914 -17.336 1.00 44.47  ? 574  GLN A N   1 
ATOM   2165 C  CA  . GLN A 1 311 ? -14.136 -14.997 -17.275 1.00 46.28  ? 574  GLN A CA  1 
ATOM   2166 C  C   . GLN A 1 311 ? -14.056 -14.241 -15.936 1.00 51.30  ? 574  GLN A C   1 
ATOM   2167 O  O   . GLN A 1 311 ? -13.054 -13.538 -15.715 1.00 51.12  ? 574  GLN A O   1 
ATOM   2168 C  CB  . GLN A 1 311 ? -14.184 -14.057 -18.465 1.00 49.32  ? 574  GLN A CB  1 
ATOM   2169 C  CG  . GLN A 1 311 ? -13.998 -14.792 -19.776 1.00 50.32  ? 574  GLN A CG  1 
ATOM   2170 C  CD  . GLN A 1 311 ? -14.197 -13.866 -20.940 1.00 51.62  ? 574  GLN A CD  1 
ATOM   2171 O  OE1 . GLN A 1 311 ? -14.450 -12.686 -20.762 1.00 66.15  ? 574  GLN A OE1 1 
ATOM   2172 N  NE2 . GLN A 1 311 ? -14.060 -14.390 -22.141 1.00 57.18  ? 574  GLN A NE2 1 
ATOM   2173 N  N   . ASN A 1 312 ? -15.054 -14.393 -15.050 0.50 52.73  ? 575  ASN A N   1 
ATOM   2174 C  CA  . ASN A 1 312 ? -15.109 -13.746 -13.705 0.50 54.23  ? 575  ASN A CA  1 
ATOM   2175 C  C   . ASN A 1 312 ? -15.974 -14.584 -12.748 0.50 54.95  ? 575  ASN A C   1 
ATOM   2176 O  O   . ASN A 1 312 ? -17.185 -14.314 -12.670 0.50 60.76  ? 575  ASN A O   1 
ATOM   2177 C  CB  . ASN A 1 312 ? -15.683 -12.323 -13.767 0.50 52.36  ? 575  ASN A CB  1 
ATOM   2178 C  CG  . ASN A 1 312 ? -14.850 -11.348 -14.574 0.50 52.37  ? 575  ASN A CG  1 
ATOM   2179 O  OD1 . ASN A 1 312 ? -13.830 -10.853 -14.101 0.50 53.92  ? 575  ASN A OD1 1 
ATOM   2180 N  ND2 . ASN A 1 312 ? -15.286 -11.046 -15.788 0.50 51.31  ? 575  ASN A ND2 1 
ATOM   2181 N  N   . LYS A 1 313 ? -15.378 -15.524 -12.005 0.50 54.45  ? 576  LYS A N   1 
ATOM   2182 C  CA  . LYS A 1 313 ? -16.119 -16.555 -11.222 0.50 54.97  ? 576  LYS A CA  1 
ATOM   2183 C  C   . LYS A 1 313 ? -16.176 -16.185 -9.734  0.50 54.89  ? 576  LYS A C   1 
ATOM   2184 O  O   . LYS A 1 313 ? -15.247 -15.513 -9.254  0.50 56.64  ? 576  LYS A O   1 
ATOM   2185 C  CB  . LYS A 1 313 ? -15.449 -17.927 -11.350 0.50 56.34  ? 576  LYS A CB  1 
ATOM   2186 C  CG  . LYS A 1 313 ? -14.858 -18.246 -12.715 0.50 57.36  ? 576  LYS A CG  1 
ATOM   2187 C  CD  . LYS A 1 313 ? -13.987 -19.486 -12.705 0.50 58.21  ? 576  LYS A CD  1 
ATOM   2188 C  CE  . LYS A 1 313 ? -13.223 -19.667 -13.997 0.50 58.72  ? 576  LYS A CE  1 
ATOM   2189 N  NZ  . LYS A 1 313 ? -12.480 -18.437 -14.355 0.50 59.92  ? 576  LYS A NZ  1 
ATOM   2190 N  N   . VAL A 1 314 ? -17.223 -16.651 -9.046  0.50 52.38  ? 577  VAL A N   1 
ATOM   2191 C  CA  . VAL A 1 314 ? -17.404 -16.586 -7.567  0.50 53.83  ? 577  VAL A CA  1 
ATOM   2192 C  C   . VAL A 1 314 ? -17.649 -18.014 -7.084  0.50 52.43  ? 577  VAL A C   1 
ATOM   2193 O  O   . VAL A 1 314 ? -18.546 -18.678 -7.631  0.50 47.88  ? 577  VAL A O   1 
ATOM   2194 C  CB  . VAL A 1 314 ? -18.567 -15.658 -7.164  0.50 56.11  ? 577  VAL A CB  1 
ATOM   2195 C  CG1 . VAL A 1 314 ? -18.845 -15.729 -5.668  0.50 56.72  ? 577  VAL A CG1 1 
ATOM   2196 C  CG2 . VAL A 1 314 ? -18.322 -14.221 -7.604  0.50 55.76  ? 577  VAL A CG2 1 
ATOM   2197 N  N   . VAL A 1 315 ? -16.862 -18.474 -6.113  0.50 52.37  ? 578  VAL A N   1 
ATOM   2198 C  CA  . VAL A 1 315 ? -16.891 -19.888 -5.645  0.50 54.25  ? 578  VAL A CA  1 
ATOM   2199 C  C   . VAL A 1 315 ? -16.969 -19.905 -4.120  0.50 55.34  ? 578  VAL A C   1 
ATOM   2200 O  O   . VAL A 1 315 ? -16.320 -19.057 -3.477  0.50 53.95  ? 578  VAL A O   1 
ATOM   2201 C  CB  . VAL A 1 315 ? -15.660 -20.665 -6.147  0.50 56.15  ? 578  VAL A CB  1 
ATOM   2202 C  CG1 . VAL A 1 315 ? -15.727 -22.128 -5.744  0.50 57.31  ? 578  VAL A CG1 1 
ATOM   2203 C  CG2 . VAL A 1 315 ? -15.484 -20.525 -7.652  0.50 57.91  ? 578  VAL A CG2 1 
ATOM   2204 N  N   . ARG A 1 316 ? -17.734 -20.850 -3.579  0.50 58.17  ? 579  ARG A N   1 
ATOM   2205 C  CA  . ARG A 1 316 ? -17.810 -21.129 -2.126  0.50 63.52  ? 579  ARG A CA  1 
ATOM   2206 C  C   . ARG A 1 316 ? -17.157 -22.493 -1.871  0.50 64.57  ? 579  ARG A C   1 
ATOM   2207 O  O   . ARG A 1 316 ? -17.551 -23.473 -2.534  0.50 66.98  ? 579  ARG A O   1 
ATOM   2208 C  CB  . ARG A 1 316 ? -19.267 -21.059 -1.662  0.50 66.82  ? 579  ARG A CB  1 
ATOM   2209 C  CG  . ARG A 1 316 ? -20.163 -22.142 -2.241  0.50 71.48  ? 579  ARG A CG  1 
ATOM   2210 C  CD  . ARG A 1 316 ? -21.564 -22.022 -1.674  0.50 77.26  ? 579  ARG A CD  1 
ATOM   2211 N  NE  . ARG A 1 316 ? -22.115 -20.689 -1.865  0.50 79.58  ? 579  ARG A NE  1 
ATOM   2212 C  CZ  . ARG A 1 316 ? -23.344 -20.329 -1.519  0.50 81.34  ? 579  ARG A CZ  1 
ATOM   2213 N  NH1 . ARG A 1 316 ? -23.754 -19.091 -1.731  0.50 83.12  ? 579  ARG A NH1 1 
ATOM   2214 N  NH2 . ARG A 1 316 ? -24.158 -21.210 -0.963  0.50 81.82  ? 579  ARG A NH2 1 
ATOM   2215 N  N   . VAL A 1 317 ? -16.175 -22.540 -0.967  0.50 63.60  ? 580  VAL A N   1 
ATOM   2216 C  CA  . VAL A 1 317 ? -15.362 -23.755 -0.663  0.50 64.18  ? 580  VAL A CA  1 
ATOM   2217 C  C   . VAL A 1 317 ? -15.400 -24.016 0.847   0.50 65.92  ? 580  VAL A C   1 
ATOM   2218 O  O   . VAL A 1 317 ? -15.240 -23.051 1.617   0.50 62.72  ? 580  VAL A O   1 
ATOM   2219 C  CB  . VAL A 1 317 ? -13.914 -23.597 -1.168  0.50 61.88  ? 580  VAL A CB  1 
ATOM   2220 C  CG1 . VAL A 1 317 ? -13.097 -24.856 -0.932  0.50 61.46  ? 580  VAL A CG1 1 
ATOM   2221 C  CG2 . VAL A 1 317 ? -13.867 -23.197 -2.633  0.50 61.20  ? 580  VAL A CG2 1 
ATOM   2222 N  N   . GLN A 1 318 ? -15.603 -25.278 1.238   0.50 70.45  ? 581  GLN A N   1 
ATOM   2223 C  CA  . GLN A 1 318 ? -15.643 -25.741 2.652   0.50 72.37  ? 581  GLN A CA  1 
ATOM   2224 C  C   . GLN A 1 318 ? -14.213 -25.930 3.169   0.50 75.74  ? 581  GLN A C   1 
ATOM   2225 O  O   . GLN A 1 318 ? -13.474 -26.734 2.565   0.50 73.20  ? 581  GLN A O   1 
ATOM   2226 C  CB  . GLN A 1 318 ? -16.421 -27.053 2.748   0.50 70.12  ? 581  GLN A CB  1 
ATOM   2227 C  CG  . GLN A 1 318 ? -17.926 -26.873 2.637   0.50 71.02  ? 581  GLN A CG  1 
ATOM   2228 C  CD  . GLN A 1 318 ? -18.603 -27.004 3.979   0.50 70.48  ? 581  GLN A CD  1 
ATOM   2229 O  OE1 . GLN A 1 318 ? -18.165 -27.762 4.841   0.50 69.21  ? 581  GLN A OE1 1 
ATOM   2230 N  NE2 . GLN A 1 318 ? -19.687 -26.267 4.162   0.50 71.05  ? 581  GLN A NE2 1 
ATOM   2231 N  N   . ARG A 1 319 ? -13.853 -25.219 4.246   0.50 81.79  ? 582  ARG A N   1 
ATOM   2232 C  CA  . ARG A 1 319 ? -12.534 -25.315 4.932   0.50 84.32  ? 582  ARG A CA  1 
ATOM   2233 C  C   . ARG A 1 319 ? -12.743 -25.860 6.343   0.50 88.75  ? 582  ARG A C   1 
ATOM   2234 O  O   . ARG A 1 319 ? -13.558 -25.333 7.098   0.50 89.59  ? 582  ARG A O   1 
ATOM   2235 C  CB  . ARG A 1 319 ? -11.843 -23.947 4.949   0.50 82.20  ? 582  ARG A CB  1 
ATOM   2236 C  CG  . ARG A 1 319 ? -10.425 -23.971 5.504   0.50 79.52  ? 582  ARG A CG  1 
ATOM   2237 C  CD  . ARG A 1 319 ? -9.550  -22.891 4.897   0.50 78.02  ? 582  ARG A CD  1 
ATOM   2238 N  NE  . ARG A 1 319 ? -10.165 -21.576 4.987   0.50 76.73  ? 582  ARG A NE  1 
ATOM   2239 C  CZ  . ARG A 1 319 ? -9.845  -20.655 5.886   0.50 78.07  ? 582  ARG A CZ  1 
ATOM   2240 N  NH1 . ARG A 1 319 ? -8.903  -20.900 6.781   0.50 79.01  ? 582  ARG A NH1 1 
ATOM   2241 N  NH2 . ARG A 1 319 ? -10.466 -19.489 5.887   0.50 76.22  ? 582  ARG A NH2 1 
ATOM   2242 N  N   . PRO A 1 320 ? -12.025 -26.940 6.733   0.50 95.37  ? 583  PRO A N   1 
ATOM   2243 C  CA  . PRO A 1 320 ? -12.182 -27.552 8.056   0.50 94.34  ? 583  PRO A CA  1 
ATOM   2244 C  C   . PRO A 1 320 ? -11.736 -26.633 9.206   0.50 90.55  ? 583  PRO A C   1 
ATOM   2245 O  O   . PRO A 1 320 ? -12.267 -26.758 10.298  0.50 89.79  ? 583  PRO A O   1 
ATOM   2246 C  CB  . PRO A 1 320 ? -11.283 -28.802 8.005   0.50 95.00  ? 583  PRO A CB  1 
ATOM   2247 C  CG  . PRO A 1 320 ? -11.016 -29.033 6.528   0.50 95.21  ? 583  PRO A CG  1 
ATOM   2248 C  CD  . PRO A 1 320 ? -11.040 -27.652 5.906   0.50 96.13  ? 583  PRO A CD  1 
ATOM   2249 N  N   . THR A 1 321 ? -10.774 -25.746 8.932   0.50 87.98  ? 584  THR A N   1 
ATOM   2250 C  CA  . THR A 1 321 ? -10.222 -24.751 9.891   0.50 86.02  ? 584  THR A CA  1 
ATOM   2251 C  C   . THR A 1 321 ? -11.366 -24.143 10.712  0.50 82.73  ? 584  THR A C   1 
ATOM   2252 O  O   . THR A 1 321 ? -11.264 -24.192 11.960  0.50 78.53  ? 584  THR A O   1 
ATOM   2253 C  CB  . THR A 1 321 ? -9.422  -23.673 9.147   0.50 87.44  ? 584  THR A CB  1 
ATOM   2254 O  OG1 . THR A 1 321 ? -10.335 -22.888 8.378   0.50 88.08  ? 584  THR A OG1 1 
ATOM   2255 C  CG2 . THR A 1 321 ? -8.360  -24.248 8.236   0.50 86.28  ? 584  THR A CG2 1 
ATOM   2256 N  N   . THR A 1 325 ? -15.505 -24.669 10.833  0.50 78.59  ? 588  THR A N   1 
ATOM   2257 C  CA  . THR A 1 325 ? -16.002 -24.749 9.433   0.50 79.89  ? 588  THR A CA  1 
ATOM   2258 C  C   . THR A 1 325 ? -16.434 -23.351 8.972   0.50 77.57  ? 588  THR A C   1 
ATOM   2259 O  O   . THR A 1 325 ? -17.544 -22.920 9.351   0.50 72.33  ? 588  THR A O   1 
ATOM   2260 C  CB  . THR A 1 325 ? -17.142 -25.769 9.311   0.50 81.48  ? 588  THR A CB  1 
ATOM   2261 O  OG1 . THR A 1 325 ? -16.698 -27.004 9.874   0.50 86.65  ? 588  THR A OG1 1 
ATOM   2262 C  CG2 . THR A 1 325 ? -17.589 -25.994 7.883   0.50 83.10  ? 588  THR A CG2 1 
ATOM   2263 N  N   . VAL A 1 326 ? -15.583 -22.670 8.196   0.50 76.55  ? 589  VAL A N   1 
ATOM   2264 C  CA  . VAL A 1 326 ? -15.883 -21.344 7.576   0.50 76.55  ? 589  VAL A CA  1 
ATOM   2265 C  C   . VAL A 1 326 ? -16.000 -21.524 6.059   0.50 75.11  ? 589  VAL A C   1 
ATOM   2266 O  O   . VAL A 1 326 ? -15.069 -22.098 5.453   0.50 73.65  ? 589  VAL A O   1 
ATOM   2267 C  CB  . VAL A 1 326 ? -14.814 -20.287 7.914   0.50 78.07  ? 589  VAL A CB  1 
ATOM   2268 C  CG1 . VAL A 1 326 ? -14.308 -20.426 9.341   0.50 81.16  ? 589  VAL A CG1 1 
ATOM   2269 C  CG2 . VAL A 1 326 ? -13.657 -20.327 6.927   0.50 80.10  ? 589  VAL A CG2 1 
ATOM   2270 N  N   . MET A 1 327 ? -17.102 -21.045 5.475   0.50 72.65  ? 590  MET A N   1 
ATOM   2271 C  CA  . MET A 1 327 ? -17.303 -20.981 4.004   0.50 71.16  ? 590  MET A CA  1 
ATOM   2272 C  C   . MET A 1 327 ? -16.466 -19.823 3.454   0.50 68.33  ? 590  MET A C   1 
ATOM   2273 O  O   . MET A 1 327 ? -16.699 -18.676 3.880   0.50 66.51  ? 590  MET A O   1 
ATOM   2274 C  CB  . MET A 1 327 ? -18.776 -20.763 3.644   0.50 71.21  ? 590  MET A CB  1 
ATOM   2275 C  CG  . MET A 1 327 ? -19.049 -20.870 2.155   0.50 70.79  ? 590  MET A CG  1 
ATOM   2276 S  SD  . MET A 1 327 ? -18.623 -22.501 1.484   0.50 68.98  ? 590  MET A SD  1 
ATOM   2277 C  CE  . MET A 1 327 ? -20.009 -23.474 2.073   0.50 69.11  ? 590  MET A CE  1 
ATOM   2278 N  N   . ASP A 1 328 ? -15.521 -20.124 2.559   0.50 66.77  ? 591  ASP A N   1 
ATOM   2279 C  CA  . ASP A 1 328 ? -14.633 -19.127 1.904   0.50 68.23  ? 591  ASP A CA  1 
ATOM   2280 C  C   . ASP A 1 328 ? -15.232 -18.727 0.551   0.50 66.64  ? 591  ASP A C   1 
ATOM   2281 O  O   . ASP A 1 328 ? -15.420 -19.614 -0.302  0.50 64.87  ? 591  ASP A O   1 
ATOM   2282 C  CB  . ASP A 1 328 ? -13.216 -19.676 1.736   0.50 68.57  ? 591  ASP A CB  1 
ATOM   2283 C  CG  . ASP A 1 328 ? -12.479 -19.854 3.052   0.50 70.98  ? 591  ASP A CG  1 
ATOM   2284 O  OD1 . ASP A 1 328 ? -12.313 -18.840 3.769   0.50 69.11  ? 591  ASP A OD1 1 
ATOM   2285 O  OD2 . ASP A 1 328 ? -12.087 -21.004 3.351   0.50 66.88  ? 591  ASP A OD2 1 
ATOM   2286 N  N   . ILE A 1 329 ? -15.519 -17.435 0.378   0.50 63.94  ? 592  ILE A N   1 
ATOM   2287 C  CA  . ILE A 1 329 ? -16.047 -16.848 -0.885  0.50 65.04  ? 592  ILE A CA  1 
ATOM   2288 C  C   . ILE A 1 329 ? -14.861 -16.290 -1.673  0.50 68.14  ? 592  ILE A C   1 
ATOM   2289 O  O   . ILE A 1 329 ? -14.489 -15.118 -1.448  0.50 66.98  ? 592  ILE A O   1 
ATOM   2290 C  CB  . ILE A 1 329 ? -17.112 -15.773 -0.598  0.50 66.01  ? 592  ILE A CB  1 
ATOM   2291 C  CG1 . ILE A 1 329 ? -18.324 -16.366 0.126   0.50 64.72  ? 592  ILE A CG1 1 
ATOM   2292 C  CG2 . ILE A 1 329 ? -17.511 -15.052 -1.877  0.50 65.32  ? 592  ILE A CG2 1 
ATOM   2293 C  CD1 . ILE A 1 329 ? -18.825 -17.660 -0.470  0.50 63.88  ? 592  ILE A CD1 1 
ATOM   2294 N  N   . ILE A 1 330 ? -14.304 -17.118 -2.560  0.50 70.65  ? 593  ILE A N   1 
ATOM   2295 C  CA  . ILE A 1 330 ? -13.072 -16.828 -3.350  0.50 71.15  ? 593  ILE A CA  1 
ATOM   2296 C  C   . ILE A 1 330 ? -13.471 -16.522 -4.797  0.50 69.13  ? 593  ILE A C   1 
ATOM   2297 O  O   . ILE A 1 330 ? -14.525 -17.015 -5.231  0.50 67.66  ? 593  ILE A O   1 
ATOM   2298 C  CB  . ILE A 1 330 ? -12.098 -18.017 -3.262  0.50 73.14  ? 593  ILE A CB  1 
ATOM   2299 C  CG1 . ILE A 1 330 ? -12.787 -19.332 -3.641  0.50 71.75  ? 593  ILE A CG1 1 
ATOM   2300 C  CG2 . ILE A 1 330 ? -11.467 -18.084 -1.879  0.50 74.12  ? 593  ILE A CG2 1 
ATOM   2301 C  CD1 . ILE A 1 330 ? -11.883 -20.543 -3.591  0.50 72.16  ? 593  ILE A CD1 1 
ATOM   2302 N  N   . SER A 1 331 ? -12.646 -15.750 -5.508  0.50 68.73  ? 594  SER A N   1 
ATOM   2303 C  CA  . SER A 1 331 ? -12.883 -15.318 -6.909  0.50 69.53  ? 594  SER A CA  1 
ATOM   2304 C  C   . SER A 1 331 ? -11.597 -15.470 -7.729  0.50 69.94  ? 594  SER A C   1 
ATOM   2305 O  O   . SER A 1 331 ? -10.519 -15.111 -7.214  0.50 71.15  ? 594  SER A O   1 
ATOM   2306 C  CB  . SER A 1 331 ? -13.391 -13.902 -6.951  0.50 68.66  ? 594  SER A CB  1 
ATOM   2307 O  OG  . SER A 1 331 ? -12.409 -12.998 -6.469  0.50 69.80  ? 594  SER A OG  1 
ATOM   2308 N  N   . ARG A 1 332 ? -11.719 -15.981 -8.959  0.50 67.21  ? 595  ARG A N   1 
ATOM   2309 C  CA  . ARG A 1 332 ? -10.622 -16.033 -9.960  0.50 64.52  ? 595  ARG A CA  1 
ATOM   2310 C  C   . ARG A 1 332 ? -11.230 -15.879 -11.351 0.50 60.64  ? 595  ARG A C   1 
ATOM   2311 O  O   . ARG A 1 332 ? -12.403 -16.259 -11.521 0.50 61.32  ? 595  ARG A O   1 
ATOM   2312 C  CB  . ARG A 1 332 ? -9.848  -17.349 -9.871  0.50 67.47  ? 595  ARG A CB  1 
ATOM   2313 C  CG  . ARG A 1 332 ? -10.513 -18.509 -10.596 0.50 70.68  ? 595  ARG A CG  1 
ATOM   2314 C  CD  . ARG A 1 332 ? -9.588  -19.710 -10.640 0.50 73.46  ? 595  ARG A CD  1 
ATOM   2315 N  NE  . ARG A 1 332 ? -8.249  -19.345 -11.084 0.50 73.04  ? 595  ARG A NE  1 
ATOM   2316 C  CZ  . ARG A 1 332 ? -7.183  -19.285 -10.294 0.50 72.43  ? 595  ARG A CZ  1 
ATOM   2317 N  NH1 . ARG A 1 332 ? -7.295  -19.576 -9.010  0.50 73.21  ? 595  ARG A NH1 1 
ATOM   2318 N  NH2 . ARG A 1 332 ? -6.008  -18.945 -10.792 0.50 71.81  ? 595  ARG A NH2 1 
ATOM   2319 N  N   . ARG A 1 333 ? -10.444 -15.354 -12.293 0.50 56.77  ? 596  ARG A N   1 
ATOM   2320 C  CA  . ARG A 1 333 ? -10.948 -15.095 -13.664 0.50 56.99  ? 596  ARG A CA  1 
ATOM   2321 C  C   . ARG A 1 333 ? -10.579 -16.239 -14.615 0.50 51.92  ? 596  ARG A C   1 
ATOM   2322 O  O   . ARG A 1 333 ? -11.294 -16.410 -15.614 0.50 49.00  ? 596  ARG A O   1 
ATOM   2323 C  CB  . ARG A 1 333 ? -10.339 -13.793 -14.187 0.50 58.69  ? 596  ARG A CB  1 
ATOM   2324 C  CG  . ARG A 1 333 ? -10.839 -12.536 -13.490 0.50 61.75  ? 596  ARG A CG  1 
ATOM   2325 C  CD  . ARG A 1 333 ? -10.569 -11.328 -14.365 0.50 65.02  ? 596  ARG A CD  1 
ATOM   2326 N  NE  . ARG A 1 333 ? -11.244 -11.450 -15.649 0.50 64.32  ? 596  ARG A NE  1 
ATOM   2327 C  CZ  . ARG A 1 333 ? -11.019 -10.668 -16.698 0.50 67.62  ? 596  ARG A CZ  1 
ATOM   2328 N  NH1 . ARG A 1 333 ? -10.120 -9.702  -16.625 0.50 69.74  ? 596  ARG A NH1 1 
ATOM   2329 N  NH2 . ARG A 1 333 ? -11.687 -10.861 -17.822 0.50 66.67  ? 596  ARG A NH2 1 
ATOM   2330 N  N   . ASP A 1 334 ? -9.508  -16.978 -14.329 0.50 49.96  ? 597  ASP A N   1 
ATOM   2331 C  CA  . ASP A 1 334 ? -9.038  -18.023 -15.278 0.50 49.57  ? 597  ASP A CA  1 
ATOM   2332 C  C   . ASP A 1 334 ? -9.421  -19.426 -14.797 0.50 45.72  ? 597  ASP A C   1 
ATOM   2333 O  O   . ASP A 1 334 ? -10.115 -19.522 -13.775 0.50 45.10  ? 597  ASP A O   1 
ATOM   2334 C  CB  . ASP A 1 334 ? -7.531  -17.915 -15.512 0.50 50.62  ? 597  ASP A CB  1 
ATOM   2335 C  CG  . ASP A 1 334 ? -6.697  -18.179 -14.272 0.50 51.48  ? 597  ASP A CG  1 
ATOM   2336 O  OD1 . ASP A 1 334 ? -7.288  -18.299 -13.185 0.50 50.60  ? 597  ASP A OD1 1 
ATOM   2337 O  OD2 . ASP A 1 334 ? -5.463  -18.266 -14.407 0.50 53.75  ? 597  ASP A OD2 1 
ATOM   2338 N  N   . GLN A 1 335 ? -8.989  -20.459 -15.530 0.50 44.28  ? 598  GLN A N   1 
ATOM   2339 C  CA  . GLN A 1 335 ? -9.292  -21.877 -15.184 0.50 43.93  ? 598  GLN A CA  1 
ATOM   2340 C  C   . GLN A 1 335 ? -10.717 -22.230 -15.625 0.50 44.45  ? 598  GLN A C   1 
ATOM   2341 O  O   . GLN A 1 335 ? -11.472 -21.305 -15.959 0.50 43.55  ? 598  GLN A O   1 
ATOM   2342 C  CB  . GLN A 1 335 ? -9.060  -22.157 -13.697 0.50 43.62  ? 598  GLN A CB  1 
ATOM   2343 C  CG  . GLN A 1 335 ? -7.605  -22.035 -13.273 0.50 45.20  ? 598  GLN A CG  1 
ATOM   2344 C  CD  . GLN A 1 335 ? -7.352  -22.690 -11.938 0.50 46.21  ? 598  GLN A CD  1 
ATOM   2345 O  OE1 . GLN A 1 335 ? -8.245  -23.282 -11.338 0.50 49.18  ? 598  GLN A OE1 1 
ATOM   2346 N  NE2 . GLN A 1 335 ? -6.121  -22.595 -11.465 0.50 45.21  ? 598  GLN A NE2 1 
ATOM   2347 N  N   . ARG A 1 336 ? -10.984 -23.529 -15.758 0.50 44.31  ? 599  ARG A N   1 
ATOM   2348 C  CA  . ARG A 1 336 ? -12.316 -24.002 -16.203 0.50 44.34  ? 599  ARG A CA  1 
ATOM   2349 C  C   . ARG A 1 336 ? -13.141 -24.376 -14.976 0.50 47.50  ? 599  ARG A C   1 
ATOM   2350 O  O   . ARG A 1 336 ? -12.605 -25.063 -14.094 0.50 46.22  ? 599  ARG A O   1 
ATOM   2351 C  CB  . ARG A 1 336 ? -12.166 -25.209 -17.133 0.50 43.65  ? 599  ARG A CB  1 
ATOM   2352 C  CG  . ARG A 1 336 ? -13.483 -25.851 -17.543 0.50 42.35  ? 599  ARG A CG  1 
ATOM   2353 C  CD  . ARG A 1 336 ? -14.041 -25.232 -18.808 0.50 42.54  ? 599  ARG A CD  1 
ATOM   2354 N  NE  . ARG A 1 336 ? -13.201 -25.532 -19.957 0.50 39.51  ? 599  ARG A NE  1 
ATOM   2355 C  CZ  . ARG A 1 336 ? -12.867 -24.654 -20.893 0.50 37.77  ? 599  ARG A CZ  1 
ATOM   2356 N  NH1 . ARG A 1 336 ? -13.300 -23.409 -20.815 0.50 37.56  ? 599  ARG A NH1 1 
ATOM   2357 N  NH2 . ARG A 1 336 ? -12.100 -25.025 -21.902 0.50 35.04  ? 599  ARG A NH2 1 
ATOM   2358 N  N   . GLY A 1 337 ? -14.393 -23.923 -14.930 0.50 50.62  ? 600  GLY A N   1 
ATOM   2359 C  CA  . GLY A 1 337 ? -15.291 -24.264 -13.813 0.50 56.10  ? 600  GLY A CA  1 
ATOM   2360 C  C   . GLY A 1 337 ? -16.725 -24.347 -14.288 0.50 59.20  ? 600  GLY A C   1 
ATOM   2361 O  O   . GLY A 1 337 ? -17.622 -24.411 -13.433 0.50 65.86  ? 600  GLY A O   1 
ATOM   2362 N  N   . SER A 1 338 ? -16.931 -24.384 -15.602 0.50 61.33  ? 601  SER A N   1 
ATOM   2363 C  CA  . SER A 1 338 ? -18.295 -24.416 -16.185 0.50 59.27  ? 601  SER A CA  1 
ATOM   2364 C  C   . SER A 1 338 ? -18.985 -25.750 -15.900 0.50 56.03  ? 601  SER A C   1 
ATOM   2365 O  O   . SER A 1 338 ? -18.421 -26.563 -15.152 0.50 54.77  ? 601  SER A O   1 
ATOM   2366 C  CB  . SER A 1 338 ? -18.207 -24.192 -17.665 0.50 61.71  ? 601  SER A CB  1 
ATOM   2367 O  OG  . SER A 1 338 ? -17.197 -23.244 -17.973 0.50 66.80  ? 601  SER A OG  1 
ATOM   2368 N  N   . GLY A 1 339 ? -20.170 -25.954 -16.476 0.50 55.21  ? 602  GLY A N   1 
ATOM   2369 C  CA  . GLY A 1 339 ? -20.855 -27.253 -16.348 0.50 53.69  ? 602  GLY A CA  1 
ATOM   2370 C  C   . GLY A 1 339 ? -20.075 -28.334 -17.073 0.50 51.44  ? 602  GLY A C   1 
ATOM   2371 O  O   . GLY A 1 339 ? -19.344 -27.986 -18.010 0.50 48.42  ? 602  GLY A O   1 
ATOM   2372 N  N   . GLN A 1 340 ? -20.246 -29.597 -16.677 0.50 51.20  ? 603  GLN A N   1 
ATOM   2373 C  CA  . GLN A 1 340 ? -19.436 -30.707 -17.250 0.50 51.68  ? 603  GLN A CA  1 
ATOM   2374 C  C   . GLN A 1 340 ? -19.652 -30.823 -18.761 0.50 47.75  ? 603  GLN A C   1 
ATOM   2375 O  O   . GLN A 1 340 ? -18.667 -31.056 -19.473 0.50 44.12  ? 603  GLN A O   1 
ATOM   2376 C  CB  . GLN A 1 340 ? -19.774 -32.017 -16.535 0.50 54.72  ? 603  GLN A CB  1 
ATOM   2377 C  CG  . GLN A 1 340 ? -21.222 -32.455 -16.695 0.50 57.86  ? 603  GLN A CG  1 
ATOM   2378 C  CD  . GLN A 1 340 ? -21.472 -33.798 -16.055 0.50 58.68  ? 603  GLN A CD  1 
ATOM   2379 O  OE1 . GLN A 1 340 ? -20.626 -34.335 -15.345 0.50 60.48  ? 603  GLN A OE1 1 
ATOM   2380 N  NE2 . GLN A 1 340 ? -22.646 -34.355 -16.306 0.50 58.45  ? 603  GLN A NE2 1 
ATOM   2381 N  N   . VAL A 1 341 ? -20.891 -30.672 -19.223 1.00 45.75  ? 604  VAL A N   1 
ATOM   2382 C  CA  . VAL A 1 341 ? -21.181 -30.853 -20.676 1.00 42.99  ? 604  VAL A CA  1 
ATOM   2383 C  C   . VAL A 1 341 ? -20.586 -29.677 -21.454 1.00 38.89  ? 604  VAL A C   1 
ATOM   2384 O  O   . VAL A 1 341 ? -19.914 -29.934 -22.462 1.00 32.72  ? 604  VAL A O   1 
ATOM   2385 C  CB  . VAL A 1 341 ? -22.685 -31.020 -20.940 1.00 44.87  ? 604  VAL A CB  1 
ATOM   2386 C  CG1 . VAL A 1 341 ? -22.961 -31.199 -22.421 1.00 49.34  ? 604  VAL A CG1 1 
ATOM   2387 C  CG2 . VAL A 1 341 ? -23.266 -32.178 -20.145 1.00 50.23  ? 604  VAL A CG2 1 
ATOM   2388 N  N   . VAL A 1 342 ? -20.853 -28.437 -21.023 1.00 36.93  ? 605  VAL A N   1 
ATOM   2389 C  CA  . VAL A 1 342 ? -20.150 -27.300 -21.689 1.00 35.95  ? 605  VAL A CA  1 
ATOM   2390 C  C   . VAL A 1 342 ? -18.628 -27.453 -21.574 1.00 35.06  ? 605  VAL A C   1 
ATOM   2391 O  O   . VAL A 1 342 ? -17.908 -27.182 -22.555 1.00 31.58  ? 605  VAL A O   1 
ATOM   2392 C  CB  . VAL A 1 342 ? -20.663 -25.937 -21.195 1.00 38.64  ? 605  VAL A CB  1 
ATOM   2393 C  CG1 . VAL A 1 342 ? -19.882 -24.786 -21.808 1.00 36.88  ? 605  VAL A CG1 1 
ATOM   2394 C  CG2 . VAL A 1 342 ? -22.149 -25.794 -21.522 1.00 36.24  ? 605  VAL A CG2 1 
ATOM   2395 N  N   . THR A 1 343 ? -18.123 -27.872 -20.414 0.50 32.92  ? 606  THR A N   1 
ATOM   2396 C  CA  . THR A 1 343 ? -16.664 -28.061 -20.203 0.50 33.28  ? 606  THR A CA  1 
ATOM   2397 C  C   . THR A 1 343 ? -16.124 -29.068 -21.226 0.50 30.32  ? 606  THR A C   1 
ATOM   2398 O  O   . THR A 1 343 ? -15.051 -28.805 -21.772 0.50 30.77  ? 606  THR A O   1 
ATOM   2399 C  CB  . THR A 1 343 ? -16.338 -28.496 -18.773 0.50 32.76  ? 606  THR A CB  1 
ATOM   2400 O  OG1 . THR A 1 343 ? -16.528 -27.344 -17.956 0.50 34.27  ? 606  THR A OG1 1 
ATOM   2401 C  CG2 . THR A 1 343 ? -14.927 -29.021 -18.629 0.50 34.38  ? 606  THR A CG2 1 
ATOM   2402 N  N   . TYR A 1 344 ? -16.853 -30.157 -21.495 1.00 30.96  ? 607  TYR A N   1 
ATOM   2403 C  CA  . TYR A 1 344 ? -16.408 -31.164 -22.479 1.00 30.64  ? 607  TYR A CA  1 
ATOM   2404 C  C   . TYR A 1 344 ? -16.260 -30.498 -23.850 1.00 30.91  ? 607  TYR A C   1 
ATOM   2405 O  O   . TYR A 1 344 ? -15.208 -30.696 -24.480 1.00 26.64  ? 607  TYR A O   1 
ATOM   2406 C  CB  . TYR A 1 344 ? -17.363 -32.347 -22.550 1.00 30.95  ? 607  TYR A CB  1 
ATOM   2407 C  CG  . TYR A 1 344 ? -17.009 -33.344 -23.616 1.00 28.56  ? 607  TYR A CG  1 
ATOM   2408 C  CD1 . TYR A 1 344 ? -16.026 -34.290 -23.371 1.00 29.72  ? 607  TYR A CD1 1 
ATOM   2409 C  CD2 . TYR A 1 344 ? -17.563 -33.283 -24.882 1.00 30.31  ? 607  TYR A CD2 1 
ATOM   2410 C  CE1 . TYR A 1 344 ? -15.675 -35.213 -24.337 1.00 31.04  ? 607  TYR A CE1 1 
ATOM   2411 C  CE2 . TYR A 1 344 ? -17.208 -34.193 -25.869 1.00 34.34  ? 607  TYR A CE2 1 
ATOM   2412 C  CZ  . TYR A 1 344 ? -16.278 -35.182 -25.582 1.00 32.83  ? 607  TYR A CZ  1 
ATOM   2413 O  OH  . TYR A 1 344 ? -15.904 -36.084 -26.543 1.00 37.58  ? 607  TYR A OH  1 
ATOM   2414 N  N   . GLY A 1 345 ? -17.257 -29.722 -24.314 1.00 26.21  ? 608  GLY A N   1 
ATOM   2415 C  CA  . GLY A 1 345 ? -17.188 -29.146 -25.677 1.00 26.20  ? 608  GLY A CA  1 
ATOM   2416 C  C   . GLY A 1 345 ? -16.090 -28.088 -25.777 1.00 24.13  ? 608  GLY A C   1 
ATOM   2417 O  O   . GLY A 1 345 ? -15.313 -28.093 -26.739 1.00 28.85  ? 608  GLY A O   1 
ATOM   2418 N  N   . LEU A 1 346 ? -15.959 -27.220 -24.786 1.00 25.59  ? 609  LEU A N   1 
ATOM   2419 C  CA  . LEU A 1 346 ? -14.942 -26.159 -24.869 1.00 28.80  ? 609  LEU A CA  1 
ATOM   2420 C  C   . LEU A 1 346 ? -13.524 -26.754 -24.672 1.00 25.76  ? 609  LEU A C   1 
ATOM   2421 O  O   . LEU A 1 346 ? -12.576 -26.224 -25.268 1.00 26.82  ? 609  LEU A O   1 
ATOM   2422 C  CB  . LEU A 1 346 ? -15.266 -25.107 -23.813 1.00 30.59  ? 609  LEU A CB  1 
ATOM   2423 C  CG  . LEU A 1 346 ? -16.555 -24.328 -24.036 1.00 28.87  ? 609  LEU A CG  1 
ATOM   2424 C  CD1 . LEU A 1 346 ? -16.691 -23.258 -22.968 1.00 35.70  ? 609  LEU A CD1 1 
ATOM   2425 C  CD2 . LEU A 1 346 ? -16.556 -23.705 -25.412 1.00 29.48  ? 609  LEU A CD2 1 
ATOM   2426 N  N   . ASN A 1 347 ? -13.373 -27.767 -23.833 1.00 27.91  ? 610  ASN A N   1 
ATOM   2427 C  CA  . ASN A 1 347 ? -12.087 -28.519 -23.723 1.00 26.48  ? 610  ASN A CA  1 
ATOM   2428 C  C   . ASN A 1 347 ? -11.758 -29.121 -25.084 1.00 24.01  ? 610  ASN A C   1 
ATOM   2429 O  O   . ASN A 1 347 ? -10.601 -28.984 -25.523 1.00 25.13  ? 610  ASN A O   1 
ATOM   2430 C  CB  . ASN A 1 347 ? -12.095 -29.589 -22.615 1.00 25.94  ? 610  ASN A CB  1 
ATOM   2431 C  CG  . ASN A 1 347 ? -11.955 -29.016 -21.221 1.00 30.03  ? 610  ASN A CG  1 
ATOM   2432 O  OD1 . ASN A 1 347 ? -11.664 -27.845 -21.035 1.00 30.20  ? 610  ASN A OD1 1 
ATOM   2433 N  ND2 . ASN A 1 347 ? -12.124 -29.848 -20.214 1.00 31.01  ? 610  ASN A ND2 1 
ATOM   2434 N  N   . THR A 1 348 ? -12.713 -29.765 -25.765 1.00 24.90  ? 611  THR A N   1 
ATOM   2435 C  CA  . THR A 1 348 ? -12.457 -30.357 -27.099 1.00 23.85  ? 611  THR A CA  1 
ATOM   2436 C  C   . THR A 1 348 ? -11.996 -29.235 -28.050 1.00 26.83  ? 611  THR A C   1 
ATOM   2437 O  O   . THR A 1 348 ? -11.016 -29.442 -28.793 1.00 24.91  ? 611  THR A O   1 
ATOM   2438 C  CB  . THR A 1 348 ? -13.660 -31.105 -27.653 1.00 23.49  ? 611  THR A CB  1 
ATOM   2439 O  OG1 . THR A 1 348 ? -14.112 -32.102 -26.729 1.00 23.82  ? 611  THR A OG1 1 
ATOM   2440 C  CG2 . THR A 1 348 ? -13.359 -31.732 -28.982 1.00 21.88  ? 611  THR A CG2 1 
ATOM   2441 N  N   . PHE A 1 349 ? -12.699 -28.096 -28.047 1.00 26.03  ? 612  PHE A N   1 
ATOM   2442 C  CA  . PHE A 1 349 ? -12.367 -26.938 -28.918 1.00 27.22  ? 612  PHE A CA  1 
ATOM   2443 C  C   . PHE A 1 349 ? -10.907 -26.508 -28.697 1.00 24.90  ? 612  PHE A C   1 
ATOM   2444 O  O   . PHE A 1 349 ? -10.148 -26.413 -29.673 1.00 27.45  ? 612  PHE A O   1 
ATOM   2445 C  CB  . PHE A 1 349 ? -13.308 -25.774 -28.618 1.00 26.86  ? 612  PHE A CB  1 
ATOM   2446 C  CG  . PHE A 1 349 ? -13.025 -24.619 -29.527 1.00 27.94  ? 612  PHE A CG  1 
ATOM   2447 C  CD1 . PHE A 1 349 ? -13.556 -24.580 -30.799 1.00 30.50  ? 612  PHE A CD1 1 
ATOM   2448 C  CD2 . PHE A 1 349 ? -12.212 -23.593 -29.097 1.00 27.31  ? 612  PHE A CD2 1 
ATOM   2449 C  CE1 . PHE A 1 349 ? -13.271 -23.515 -31.641 1.00 31.32  ? 612  PHE A CE1 1 
ATOM   2450 C  CE2 . PHE A 1 349 ? -11.923 -22.529 -29.943 1.00 31.41  ? 612  PHE A CE2 1 
ATOM   2451 C  CZ  . PHE A 1 349 ? -12.459 -22.487 -31.201 1.00 32.14  ? 612  PHE A CZ  1 
ATOM   2452 N  N   . THR A 1 350 ? -10.558 -26.226 -27.452 1.00 24.12  ? 613  THR A N   1 
ATOM   2453 C  CA  . THR A 1 350 ? -9.260  -25.604 -27.105 1.00 29.81  ? 613  THR A CA  1 
ATOM   2454 C  C   . THR A 1 350 ? -8.140  -26.637 -27.297 1.00 28.33  ? 613  THR A C   1 
ATOM   2455 O  O   . THR A 1 350 ? -7.042  -26.259 -27.736 1.00 28.45  ? 613  THR A O   1 
ATOM   2456 C  CB  . THR A 1 350 ? -9.312  -25.000 -25.709 1.00 31.55  ? 613  THR A CB  1 
ATOM   2457 O  OG1 . THR A 1 350 ? -10.260 -23.932 -25.767 1.00 31.90  ? 613  THR A OG1 1 
ATOM   2458 C  CG2 . THR A 1 350 ? -7.966  -24.435 -25.298 1.00 33.98  ? 613  THR A CG2 1 
ATOM   2459 N  N   . ASN A 1 351 ? -8.438  -27.922 -27.108 1.00 25.46  ? 614  ASN A N   1 
ATOM   2460 C  CA  . ASN A 1 351 ? -7.474  -29.024 -27.365 1.00 26.32  ? 614  ASN A CA  1 
ATOM   2461 C  C   . ASN A 1 351 ? -7.266  -29.151 -28.878 1.00 25.29  ? 614  ASN A C   1 
ATOM   2462 O  O   . ASN A 1 351 ? -6.101  -29.254 -29.317 1.00 27.68  ? 614  ASN A O   1 
ATOM   2463 C  CB  . ASN A 1 351 ? -7.897  -30.293 -26.612 1.00 24.66  ? 614  ASN A CB  1 
ATOM   2464 C  CG  . ASN A 1 351 ? -6.742  -31.250 -26.367 1.00 29.05  ? 614  ASN A CG  1 
ATOM   2465 O  OD1 . ASN A 1 351 ? -5.571  -30.927 -26.632 1.00 29.40  ? 614  ASN A OD1 1 
ATOM   2466 N  ND2 . ASN A 1 351 ? -7.058  -32.418 -25.833 1.00 27.99  ? 614  ASN A ND2 1 
ATOM   2467 N  N   . MET A 1 352 ? -8.335  -29.060 -29.690 1.00 22.39  ? 615  MET A N   1 
ATOM   2468 C  CA  . MET A 1 352 ? -8.181  -29.144 -31.144 1.00 24.18  ? 615  MET A CA  1 
ATOM   2469 C  C   . MET A 1 352 ? -7.274  -27.981 -31.593 1.00 26.19  ? 615  MET A C   1 
ATOM   2470 O  O   . MET A 1 352 ? -6.349  -28.189 -32.455 1.00 26.86  ? 615  MET A O   1 
ATOM   2471 C  CB  . MET A 1 352 ? -9.529  -29.045 -31.888 1.00 25.07  ? 615  MET A CB  1 
ATOM   2472 C  CG  . MET A 1 352 ? -10.365 -30.255 -31.736 1.00 25.97  ? 615  MET A CG  1 
ATOM   2473 S  SD  . MET A 1 352 ? -12.070 -29.980 -32.438 1.00 30.84  ? 615  MET A SD  1 
ATOM   2474 C  CE  . MET A 1 352 ? -11.819 -29.752 -34.181 1.00 29.67  ? 615  MET A CE  1 
ATOM   2475 N  N   . GLU A 1 353 ? -7.495  -26.823 -31.020 1.00 25.76  ? 616  GLU A N   1 
ATOM   2476 C  CA  . GLU A 1 353 ? -6.718  -25.590 -31.388 1.00 28.57  ? 616  GLU A CA  1 
ATOM   2477 C  C   . GLU A 1 353 ? -5.231  -25.798 -31.023 1.00 27.88  ? 616  GLU A C   1 
ATOM   2478 O  O   . GLU A 1 353 ? -4.356  -25.575 -31.848 1.00 27.99  ? 616  GLU A O   1 
ATOM   2479 C  CB  . GLU A 1 353 ? -7.323  -24.416 -30.621 1.00 31.30  ? 616  GLU A CB  1 
ATOM   2480 C  CG  . GLU A 1 353 ? -6.618  -23.077 -30.848 1.00 34.85  ? 616  GLU A CG  1 
ATOM   2481 C  CD  . GLU A 1 353 ? -6.959  -22.084 -29.747 1.00 38.65  ? 616  GLU A CD  1 
ATOM   2482 O  OE1 . GLU A 1 353 ? -8.184  -21.758 -29.625 1.00 39.98  ? 616  GLU A OE1 1 
ATOM   2483 O  OE2 . GLU A 1 353 ? -6.042  -21.755 -28.914 1.00 36.72  ? 616  GLU A OE2 1 
ATOM   2484 N  N   . ALA A 1 354 ? -4.965  -26.179 -29.791 1.00 27.91  ? 617  ALA A N   1 
ATOM   2485 C  CA  . ALA A 1 354 ? -3.605  -26.421 -29.282 1.00 28.66  ? 617  ALA A CA  1 
ATOM   2486 C  C   . ALA A 1 354 ? -2.886  -27.467 -30.131 1.00 30.52  ? 617  ALA A C   1 
ATOM   2487 O  O   . ALA A 1 354 ? -1.697  -27.262 -30.460 1.00 27.83  ? 617  ALA A O   1 
ATOM   2488 C  CB  . ALA A 1 354 ? -3.690  -26.838 -27.871 1.00 28.20  ? 617  ALA A CB  1 
ATOM   2489 N  N   . GLN A 1 355 ? -3.538  -28.585 -30.469 1.00 26.08  ? 618  GLN A N   1 
ATOM   2490 C  CA  . GLN A 1 355 ? -2.876  -29.636 -31.273 1.00 24.77  ? 618  GLN A CA  1 
ATOM   2491 C  C   . GLN A 1 355 ? -2.614  -29.176 -32.718 1.00 27.33  ? 618  GLN A C   1 
ATOM   2492 O  O   . GLN A 1 355 ? -1.607  -29.623 -33.317 1.00 26.43  ? 618  GLN A O   1 
ATOM   2493 C  CB  . GLN A 1 355 ? -3.649  -30.951 -31.189 1.00 24.04  ? 618  GLN A CB  1 
ATOM   2494 C  CG  . GLN A 1 355 ? -3.861  -31.489 -29.788 1.00 24.11  ? 618  GLN A CG  1 
ATOM   2495 C  CD  . GLN A 1 355 ? -2.599  -31.665 -28.973 1.00 27.99  ? 618  GLN A CD  1 
ATOM   2496 O  OE1 . GLN A 1 355 ? -1.536  -32.064 -29.447 1.00 25.88  ? 618  GLN A OE1 1 
ATOM   2497 N  NE2 . GLN A 1 355 ? -2.746  -31.409 -27.693 1.00 27.58  ? 618  GLN A NE2 1 
ATOM   2498 N  N   . LEU A 1 356 ? -3.495  -28.399 -33.365 1.00 27.91  ? 619  LEU A N   1 
ATOM   2499 C  CA  . LEU A 1 356 ? -3.213  -27.850 -34.720 1.00 27.78  ? 619  LEU A CA  1 
ATOM   2500 C  C   . LEU A 1 356 ? -1.972  -26.949 -34.611 1.00 28.28  ? 619  LEU A C   1 
ATOM   2501 O  O   . LEU A 1 356 ? -1.118  -27.021 -35.507 1.00 33.74  ? 619  LEU A O   1 
ATOM   2502 C  CB  . LEU A 1 356 ? -4.374  -26.987 -35.252 1.00 29.54  ? 619  LEU A CB  1 
ATOM   2503 C  CG  . LEU A 1 356 ? -5.527  -27.726 -35.915 1.00 31.89  ? 619  LEU A CG  1 
ATOM   2504 C  CD1 . LEU A 1 356 ? -6.653  -26.745 -36.248 1.00 33.93  ? 619  LEU A CD1 1 
ATOM   2505 C  CD2 . LEU A 1 356 ? -5.116  -28.491 -37.158 1.00 32.65  ? 619  LEU A CD2 1 
ATOM   2506 N  N   . ILE A 1 357 ? -1.861  -26.183 -33.550 1.00 27.71  ? 620  ILE A N   1 
ATOM   2507 C  CA  . ILE A 1 357 ? -0.689  -25.266 -33.375 1.00 29.83  ? 620  ILE A CA  1 
ATOM   2508 C  C   . ILE A 1 357 ? 0.577   -26.104 -33.147 1.00 34.49  ? 620  ILE A C   1 
ATOM   2509 O  O   . ILE A 1 357 ? 1.592   -25.809 -33.807 1.00 30.15  ? 620  ILE A O   1 
ATOM   2510 C  CB  . ILE A 1 357 ? -0.947  -24.272 -32.259 1.00 32.46  ? 620  ILE A CB  1 
ATOM   2511 C  CG1 . ILE A 1 357 ? -2.082  -23.337 -32.686 1.00 33.06  ? 620  ILE A CG1 1 
ATOM   2512 C  CG2 . ILE A 1 357 ? 0.307   -23.493 -31.872 1.00 36.30  ? 620  ILE A CG2 1 
ATOM   2513 C  CD1 . ILE A 1 357 ? -2.522  -22.431 -31.603 1.00 33.23  ? 620  ILE A CD1 1 
ATOM   2514 N  N   . ARG A 1 358 ? 0.504   -27.189 -32.360 1.00 29.52  ? 621  ARG A N   1 
ATOM   2515 C  CA  . ARG A 1 358 ? 1.672   -28.076 -32.212 1.00 27.48  ? 621  ARG A CA  1 
ATOM   2516 C  C   . ARG A 1 358 ? 2.026   -28.661 -33.572 1.00 28.56  ? 621  ARG A C   1 
ATOM   2517 O  O   . ARG A 1 358 ? 3.283   -28.769 -33.892 1.00 30.74  ? 621  ARG A O   1 
ATOM   2518 C  CB  . ARG A 1 358 ? 1.461   -29.113 -31.107 1.00 30.54  ? 621  ARG A CB  1 
ATOM   2519 C  CG  . ARG A 1 358 ? 2.687   -29.993 -30.942 1.00 30.33  ? 621  ARG A CG  1 
ATOM   2520 C  CD  . ARG A 1 358 ? 2.600   -30.809 -29.674 1.00 29.92  ? 621  ARG A CD  1 
ATOM   2521 N  NE  . ARG A 1 358 ? 3.754   -31.707 -29.584 1.00 30.74  ? 621  ARG A NE  1 
ATOM   2522 C  CZ  . ARG A 1 358 ? 3.927   -32.688 -28.697 1.00 31.43  ? 621  ARG A CZ  1 
ATOM   2523 N  NH1 . ARG A 1 358 ? 2.967   -33.067 -27.876 1.00 28.12  ? 621  ARG A NH1 1 
ATOM   2524 N  NH2 . ARG A 1 358 ? 5.074   -33.368 -28.710 1.00 32.38  ? 621  ARG A NH2 1 
ATOM   2525 N  N   . GLN A 1 359 ? 1.040   -29.100 -34.363 1.00 25.16  ? 622  GLN A N   1 
ATOM   2526 C  CA  . GLN A 1 359 ? 1.305   -29.591 -35.731 1.00 24.74  ? 622  GLN A CA  1 
ATOM   2527 C  C   . GLN A 1 359 ? 1.985   -28.449 -36.545 1.00 31.74  ? 622  GLN A C   1 
ATOM   2528 O  O   . GLN A 1 359 ? 2.975   -28.714 -37.256 1.00 38.03  ? 622  GLN A O   1 
ATOM   2529 C  CB  . GLN A 1 359 ? 0.091   -30.138 -36.456 1.00 26.44  ? 622  GLN A CB  1 
ATOM   2530 C  CG  . GLN A 1 359 ? -0.472  -31.448 -35.890 1.00 26.18  ? 622  GLN A CG  1 
ATOM   2531 C  CD  . GLN A 1 359 ? -1.448  -32.101 -36.813 1.00 27.73  ? 622  GLN A CD  1 
ATOM   2532 O  OE1 . GLN A 1 359 ? -1.101  -32.581 -37.891 1.00 27.72  ? 622  GLN A OE1 1 
ATOM   2533 N  NE2 . GLN A 1 359 ? -2.697  -32.185 -36.367 1.00 27.77  ? 622  GLN A NE2 1 
ATOM   2534 N  N   . MET A 1 360 ? 1.487   -27.227 -36.512 1.00 30.72  ? 623  MET A N   1 
ATOM   2535 C  CA  . MET A 1 360 ? 2.118   -26.113 -37.298 1.00 34.70  ? 623  MET A CA  1 
ATOM   2536 C  C   . MET A 1 360 ? 3.588   -25.973 -36.860 1.00 33.11  ? 623  MET A C   1 
ATOM   2537 O  O   . MET A 1 360 ? 4.436   -25.778 -37.724 1.00 34.60  ? 623  MET A O   1 
ATOM   2538 C  CB  . MET A 1 360 ? 1.436   -24.765 -37.035 1.00 37.24  ? 623  MET A CB  1 
ATOM   2539 C  CG  . MET A 1 360 ? 0.141   -24.553 -37.772 1.00 40.31  ? 623  MET A CG  1 
ATOM   2540 S  SD  . MET A 1 360 ? -0.595  -23.071 -37.053 1.00 41.76  ? 623  MET A SD  1 
ATOM   2541 C  CE  . MET A 1 360 ? -2.341  -23.364 -37.298 1.00 44.95  ? 623  MET A CE  1 
ATOM   2542 N  N   . GLU A 1 361 ? 3.867   -25.987 -35.570 1.00 30.05  ? 624  GLU A N   1 
ATOM   2543 C  CA  . GLU A 1 361 ? 5.253   -25.892 -35.073 1.00 34.68  ? 624  GLU A CA  1 
ATOM   2544 C  C   . GLU A 1 361 ? 6.117   -26.993 -35.685 1.00 41.51  ? 624  GLU A C   1 
ATOM   2545 O  O   . GLU A 1 361 ? 7.263   -26.703 -36.080 1.00 36.98  ? 624  GLU A O   1 
ATOM   2546 C  CB  . GLU A 1 361 ? 5.300   -25.956 -33.558 1.00 36.75  ? 624  GLU A CB  1 
ATOM   2547 C  CG  . GLU A 1 361 ? 6.661   -25.559 -33.039 1.00 40.81  ? 624  GLU A CG  1 
ATOM   2548 C  CD  . GLU A 1 361 ? 6.753   -25.345 -31.546 1.00 40.67  ? 624  GLU A CD  1 
ATOM   2549 O  OE1 . GLU A 1 361 ? 7.881   -25.370 -31.044 1.00 44.73  ? 624  GLU A OE1 1 
ATOM   2550 O  OE2 . GLU A 1 361 ? 5.715   -25.147 -30.875 1.00 41.98  ? 624  GLU A OE2 1 
ATOM   2551 N  N   . GLY A 1 362 ? 5.647   -28.240 -35.699 1.00 33.09  ? 625  GLY A N   1 
ATOM   2552 C  CA  . GLY A 1 362 ? 6.449   -29.363 -36.194 1.00 33.53  ? 625  GLY A CA  1 
ATOM   2553 C  C   . GLY A 1 362 ? 6.735   -29.178 -37.678 1.00 41.39  ? 625  GLY A C   1 
ATOM   2554 O  O   . GLY A 1 362 ? 7.819   -29.593 -38.140 1.00 36.25  ? 625  GLY A O   1 
ATOM   2555 N  N   . GLU A 1 363 ? 5.782   -28.613 -38.419 1.00 32.54  ? 626  GLU A N   1 
ATOM   2556 C  CA  . GLU A 1 363 ? 5.895   -28.488 -39.888 1.00 32.56  ? 626  GLU A CA  1 
ATOM   2557 C  C   . GLU A 1 363 ? 6.669   -27.200 -40.240 1.00 33.56  ? 626  GLU A C   1 
ATOM   2558 O  O   . GLU A 1 363 ? 6.823   -26.918 -41.411 1.00 35.81  ? 626  GLU A O   1 
ATOM   2559 C  CB  . GLU A 1 363 ? 4.512   -28.494 -40.524 1.00 35.58  ? 626  GLU A CB  1 
ATOM   2560 C  CG  . GLU A 1 363 ? 3.893   -29.896 -40.524 1.00 35.55  ? 626  GLU A CG  1 
ATOM   2561 C  CD  . GLU A 1 363 ? 2.505   -29.974 -41.117 1.00 42.58  ? 626  GLU A CD  1 
ATOM   2562 O  OE1 . GLU A 1 363 ? 2.309   -29.371 -42.237 1.00 35.13  ? 626  GLU A OE1 1 
ATOM   2563 O  OE2 . GLU A 1 363 ? 1.608   -30.643 -40.473 1.00 32.94  ? 626  GLU A OE2 1 
ATOM   2564 N  N   . GLY A 1 364 ? 7.092   -26.437 -39.267 1.00 30.86  ? 627  GLY A N   1 
ATOM   2565 C  CA  . GLY A 1 364 ? 7.880   -25.212 -39.514 1.00 43.61  ? 627  GLY A CA  1 
ATOM   2566 C  C   . GLY A 1 364 ? 7.052   -24.077 -40.098 1.00 50.42  ? 627  GLY A C   1 
ATOM   2567 O  O   . GLY A 1 364 ? 7.650   -23.253 -40.825 1.00 47.55  ? 627  GLY A O   1 
ATOM   2568 N  N   . VAL A 1 365 ? 5.749   -23.969 -39.762 1.00 41.22  ? 628  VAL A N   1 
ATOM   2569 C  CA  . VAL A 1 365 ? 4.852   -22.929 -40.350 1.00 43.26  ? 628  VAL A CA  1 
ATOM   2570 C  C   . VAL A 1 365 ? 5.274   -21.565 -39.791 1.00 43.37  ? 628  VAL A C   1 
ATOM   2571 O  O   . VAL A 1 365 ? 5.179   -20.592 -40.528 1.00 47.33  ? 628  VAL A O   1 
ATOM   2572 C  CB  . VAL A 1 365 ? 3.357   -23.239 -40.117 1.00 42.61  ? 628  VAL A CB  1 
ATOM   2573 C  CG1 . VAL A 1 365 ? 2.447   -22.170 -40.712 1.00 45.76  ? 628  VAL A CG1 1 
ATOM   2574 C  CG2 . VAL A 1 365 ? 2.997   -24.587 -40.714 1.00 45.45  ? 628  VAL A CG2 1 
ATOM   2575 N  N   . PHE A 1 366 ? 5.686   -21.512 -38.524 1.00 48.30  ? 629  PHE A N   1 
ATOM   2576 C  CA  . PHE A 1 366 ? 6.233   -20.318 -37.838 1.00 46.45  ? 629  PHE A CA  1 
ATOM   2577 C  C   . PHE A 1 366 ? 7.541   -20.708 -37.146 1.00 55.06  ? 629  PHE A C   1 
ATOM   2578 O  O   . PHE A 1 366 ? 7.707   -21.878 -36.818 1.00 51.64  ? 629  PHE A O   1 
ATOM   2579 C  CB  . PHE A 1 366 ? 5.233   -19.768 -36.830 1.00 48.28  ? 629  PHE A CB  1 
ATOM   2580 C  CG  . PHE A 1 366 ? 4.987   -20.659 -35.647 1.00 47.84  ? 629  PHE A CG  1 
ATOM   2581 C  CD1 . PHE A 1 366 ? 4.020   -21.653 -35.711 1.00 45.43  ? 629  PHE A CD1 1 
ATOM   2582 C  CD2 . PHE A 1 366 ? 5.697   -20.487 -34.472 1.00 43.71  ? 629  PHE A CD2 1 
ATOM   2583 C  CE1 . PHE A 1 366 ? 3.790   -22.477 -34.624 1.00 41.59  ? 629  PHE A CE1 1 
ATOM   2584 C  CE2 . PHE A 1 366 ? 5.461   -21.315 -33.387 1.00 50.72  ? 629  PHE A CE2 1 
ATOM   2585 C  CZ  . PHE A 1 366 ? 4.501   -22.310 -33.466 1.00 43.02  ? 629  PHE A CZ  1 
ATOM   2586 N  N   . LYS A 1 367 ? 8.442   -19.750 -36.935 1.00 55.52  ? 630  LYS A N   1 
ATOM   2587 C  CA  . LYS A 1 367 ? 9.830   -20.022 -36.486 1.00 58.57  ? 630  LYS A CA  1 
ATOM   2588 C  C   . LYS A 1 367 ? 9.915   -19.780 -34.982 1.00 52.63  ? 630  LYS A C   1 
ATOM   2589 O  O   . LYS A 1 367 ? 10.663  -20.496 -34.329 1.00 52.51  ? 630  LYS A O   1 
ATOM   2590 C  CB  . LYS A 1 367 ? 10.802  -19.163 -37.298 1.00 72.04  ? 630  LYS A CB  1 
ATOM   2591 C  CG  . LYS A 1 367 ? 12.282  -19.479 -37.111 1.00 82.03  ? 630  LYS A CG  1 
ATOM   2592 C  CD  . LYS A 1 367 ? 13.193  -18.663 -38.023 1.00 86.78  ? 630  LYS A CD  1 
ATOM   2593 C  CE  . LYS A 1 367 ? 14.534  -18.324 -37.400 1.00 88.79  ? 630  LYS A CE  1 
ATOM   2594 N  NZ  . LYS A 1 367 ? 14.421  -17.246 -36.388 1.00 88.56  ? 630  LYS A NZ  1 
ATOM   2595 N  N   . SER A 1 368 ? 9.145   -18.838 -34.440 1.00 49.32  ? 631  SER A N   1 
ATOM   2596 C  CA  . SER A 1 368 ? 9.246   -18.442 -33.015 1.00 48.44  ? 631  SER A CA  1 
ATOM   2597 C  C   . SER A 1 368 ? 7.930   -17.907 -32.453 1.00 48.91  ? 631  SER A C   1 
ATOM   2598 O  O   . SER A 1 368 ? 7.202   -17.181 -33.155 1.00 48.20  ? 631  SER A O   1 
ATOM   2599 C  CB  . SER A 1 368 ? 10.314  -17.406 -32.809 1.00 58.05  ? 631  SER A CB  1 
ATOM   2600 O  OG  . SER A 1 368 ? 10.366  -17.007 -31.438 1.00 59.36  ? 631  SER A OG  1 
ATOM   2601 N  N   . ILE A 1 369 ? 7.671   -18.228 -31.182 0.50 49.47  ? 632  ILE A N   1 
ATOM   2602 C  CA  . ILE A 1 369 ? 6.417   -17.906 -30.440 0.50 52.13  ? 632  ILE A CA  1 
ATOM   2603 C  C   . ILE A 1 369 ? 6.523   -16.485 -29.886 0.50 55.03  ? 632  ILE A C   1 
ATOM   2604 O  O   . ILE A 1 369 ? 5.487   -15.933 -29.463 0.50 50.53  ? 632  ILE A O   1 
ATOM   2605 C  CB  . ILE A 1 369 ? 6.186   -18.918 -29.303 0.50 50.82  ? 632  ILE A CB  1 
ATOM   2606 C  CG1 . ILE A 1 369 ? 7.327   -18.876 -28.289 0.50 48.89  ? 632  ILE A CG1 1 
ATOM   2607 C  CG2 . ILE A 1 369 ? 5.966   -20.321 -29.853 0.50 51.29  ? 632  ILE A CG2 1 
ATOM   2608 C  CD1 . ILE A 1 369 ? 7.028   -19.600 -27.001 0.50 50.15  ? 632  ILE A CD1 1 
ATOM   2609 N  N   . GLN A 1 370 ? 7.741   -15.940 -29.842 0.50 60.05  ? 633  GLN A N   1 
ATOM   2610 C  CA  . GLN A 1 370 ? 8.014   -14.601 -29.258 0.50 61.95  ? 633  GLN A CA  1 
ATOM   2611 C  C   . GLN A 1 370 ? 7.159   -13.572 -30.003 0.50 58.60  ? 633  GLN A C   1 
ATOM   2612 O  O   . GLN A 1 370 ? 6.609   -12.670 -29.348 0.50 56.82  ? 633  GLN A O   1 
ATOM   2613 C  CB  . GLN A 1 370 ? 9.504   -14.272 -29.345 0.50 63.94  ? 633  GLN A CB  1 
ATOM   2614 C  CG  . GLN A 1 370 ? 10.083  -13.766 -28.031 0.50 67.42  ? 633  GLN A CG  1 
ATOM   2615 C  CD  . GLN A 1 370 ? 10.097  -14.833 -26.965 0.50 69.20  ? 633  GLN A CD  1 
ATOM   2616 O  OE1 . GLN A 1 370 ? 10.283  -16.015 -27.246 0.50 73.03  ? 633  GLN A OE1 1 
ATOM   2617 N  NE2 . GLN A 1 370 ? 9.902   -14.420 -25.722 0.50 70.93  ? 633  GLN A NE2 1 
ATOM   2618 N  N   . HIS A 1 371 ? 7.051   -13.725 -31.324 0.50 58.98  ? 634  HIS A N   1 
ATOM   2619 C  CA  . HIS A 1 371 ? 6.381   -12.765 -32.236 0.50 63.84  ? 634  HIS A CA  1 
ATOM   2620 C  C   . HIS A 1 371 ? 6.223   -13.402 -33.619 0.50 63.37  ? 634  HIS A C   1 
ATOM   2621 O  O   . HIS A 1 371 ? 7.205   -13.983 -34.128 0.50 59.51  ? 634  HIS A O   1 
ATOM   2622 C  CB  . HIS A 1 371 ? 7.171   -11.447 -32.279 0.50 70.25  ? 634  HIS A CB  1 
ATOM   2623 C  CG  . HIS A 1 371 ? 7.051   -10.705 -33.568 0.50 74.73  ? 634  HIS A CG  1 
ATOM   2624 N  ND1 . HIS A 1 371 ? 8.006   -10.799 -34.565 0.50 78.82  ? 634  HIS A ND1 1 
ATOM   2625 C  CD2 . HIS A 1 371 ? 6.101   -9.861  -34.028 0.50 77.53  ? 634  HIS A CD2 1 
ATOM   2626 C  CE1 . HIS A 1 371 ? 7.648   -10.045 -35.586 0.50 78.76  ? 634  HIS A CE1 1 
ATOM   2627 N  NE2 . HIS A 1 371 ? 6.482   -9.458  -35.281 0.50 79.14  ? 634  HIS A NE2 1 
ATOM   2628 N  N   . LEU A 1 372 ? 5.019   -13.303 -34.187 0.50 64.65  ? 635  LEU A N   1 
ATOM   2629 C  CA  . LEU A 1 372 ? 4.707   -13.711 -35.581 0.50 66.86  ? 635  LEU A CA  1 
ATOM   2630 C  C   . LEU A 1 372 ? 4.902   -12.509 -36.508 0.50 68.85  ? 635  LEU A C   1 
ATOM   2631 O  O   . LEU A 1 372 ? 4.240   -11.482 -36.288 0.50 70.73  ? 635  LEU A O   1 
ATOM   2632 C  CB  . LEU A 1 372 ? 3.266   -14.227 -35.655 0.50 67.28  ? 635  LEU A CB  1 
ATOM   2633 C  CG  . LEU A 1 372 ? 3.121   -15.709 -35.991 0.50 67.67  ? 635  LEU A CG  1 
ATOM   2634 C  CD1 . LEU A 1 372 ? 3.731   -16.572 -34.899 0.50 66.99  ? 635  LEU A CD1 1 
ATOM   2635 C  CD2 . LEU A 1 372 ? 1.663   -16.075 -36.222 0.50 67.69  ? 635  LEU A CD2 1 
ATOM   2636 N  N   . THR A 1 373 ? 5.780   -12.642 -37.503 0.50 70.33  ? 636  THR A N   1 
ATOM   2637 C  CA  . THR A 1 373 ? 5.951   -11.657 -38.598 0.50 70.73  ? 636  THR A CA  1 
ATOM   2638 C  C   . THR A 1 373 ? 4.618   -11.558 -39.343 0.50 72.18  ? 636  THR A C   1 
ATOM   2639 O  O   . THR A 1 373 ? 3.763   -12.442 -39.131 0.50 74.75  ? 636  THR A O   1 
ATOM   2640 C  CB  . THR A 1 373 ? 7.118   -12.052 -39.509 0.50 69.94  ? 636  THR A CB  1 
ATOM   2641 O  OG1 . THR A 1 373 ? 6.686   -13.134 -40.335 0.50 72.86  ? 636  THR A OG1 1 
ATOM   2642 C  CG2 . THR A 1 373 ? 8.355   -12.449 -38.733 0.50 70.04  ? 636  THR A CG2 1 
ATOM   2643 N  N   . VAL A 1 374 ? 4.449   -10.528 -40.173 0.50 68.96  ? 637  VAL A N   1 
ATOM   2644 C  CA  . VAL A 1 374 ? 3.190   -10.263 -40.928 0.50 70.53  ? 637  VAL A CA  1 
ATOM   2645 C  C   . VAL A 1 374 ? 2.980   -11.392 -41.945 0.50 71.55  ? 637  VAL A C   1 
ATOM   2646 O  O   . VAL A 1 374 ? 1.819   -11.814 -42.127 0.50 72.02  ? 637  VAL A O   1 
ATOM   2647 C  CB  . VAL A 1 374 ? 3.227   -8.881  -41.609 0.50 72.90  ? 637  VAL A CB  1 
ATOM   2648 C  CG1 . VAL A 1 374 ? 3.447   -7.766  -40.597 0.50 73.18  ? 637  VAL A CG1 1 
ATOM   2649 C  CG2 . VAL A 1 374 ? 4.277   -8.819  -42.708 0.50 73.52  ? 637  VAL A CG2 1 
ATOM   2650 N  N   . THR A 1 375 ? 4.062   -11.859 -42.579 0.50 69.08  ? 638  THR A N   1 
ATOM   2651 C  CA  . THR A 1 375 ? 4.039   -12.932 -43.611 0.50 68.73  ? 638  THR A CA  1 
ATOM   2652 C  C   . THR A 1 375 ? 3.848   -14.300 -42.940 0.50 64.66  ? 638  THR A C   1 
ATOM   2653 O  O   . THR A 1 375 ? 3.377   -15.222 -43.633 0.50 60.37  ? 638  THR A O   1 
ATOM   2654 C  CB  . THR A 1 375 ? 5.310   -12.923 -44.470 0.50 70.65  ? 638  THR A CB  1 
ATOM   2655 O  OG1 . THR A 1 375 ? 6.410   -13.297 -43.640 0.50 72.72  ? 638  THR A OG1 1 
ATOM   2656 C  CG2 . THR A 1 375 ? 5.582   -11.579 -45.111 0.50 73.08  ? 638  THR A CG2 1 
ATOM   2657 N  N   . GLU A 1 376 ? 4.226   -14.427 -41.661 1.00 60.89  ? 639  GLU A N   1 
ATOM   2658 C  CA  . GLU A 1 376 ? 4.012   -15.679 -40.867 1.00 65.49  ? 639  GLU A CA  1 
ATOM   2659 C  C   . GLU A 1 376 ? 2.498   -15.793 -40.639 1.00 63.69  ? 639  GLU A C   1 
ATOM   2660 O  O   . GLU A 1 376 ? 1.954   -16.856 -40.959 1.00 58.93  ? 639  GLU A O   1 
ATOM   2661 C  CB  . GLU A 1 376 ? 4.864   -15.740 -39.590 1.00 60.50  ? 639  GLU A CB  1 
ATOM   2662 C  CG  . GLU A 1 376 ? 6.252   -16.334 -39.850 1.00 55.44  ? 639  GLU A CG  1 
ATOM   2663 C  CD  . GLU A 1 376 ? 7.217   -16.406 -38.683 1.00 49.87  ? 639  GLU A CD  1 
ATOM   2664 O  OE1 . GLU A 1 376 ? 8.075   -17.308 -38.693 1.00 60.50  ? 639  GLU A OE1 1 
ATOM   2665 O  OE2 . GLU A 1 376 ? 7.135   -15.564 -37.780 1.00 58.08  ? 639  GLU A OE2 1 
ATOM   2666 N  N   . GLU A 1 377 ? 1.823   -14.687 -40.293 1.00 63.65  ? 640  GLU A N   1 
ATOM   2667 C  CA  . GLU A 1 377 ? 0.341   -14.669 -40.124 1.00 58.26  ? 640  GLU A CA  1 
ATOM   2668 C  C   . GLU A 1 377 ? -0.369  -15.208 -41.369 1.00 58.98  ? 640  GLU A C   1 
ATOM   2669 O  O   . GLU A 1 377 ? -1.229  -16.061 -41.238 1.00 62.46  ? 640  GLU A O   1 
ATOM   2670 C  CB  . GLU A 1 377 ? -0.198  -13.290 -39.797 1.00 55.48  ? 640  GLU A CB  1 
ATOM   2671 C  CG  . GLU A 1 377 ? 0.025   -12.929 -38.359 1.00 64.53  ? 640  GLU A CG  1 
ATOM   2672 C  CD  . GLU A 1 377 ? -0.600  -11.601 -37.983 1.00 69.58  ? 640  GLU A CD  1 
ATOM   2673 O  OE1 . GLU A 1 377 ? -1.735  -11.336 -38.430 1.00 72.91  ? 640  GLU A OE1 1 
ATOM   2674 O  OE2 . GLU A 1 377 ? 0.058   -10.841 -37.249 1.00 73.85  ? 640  GLU A OE2 1 
ATOM   2675 N  N   . ILE A 1 378 ? -0.004  -14.709 -42.551 0.50 59.51  ? 641  ILE A N   1 
ATOM   2676 C  CA  . ILE A 1 378 ? -0.630  -15.114 -43.846 0.50 57.86  ? 641  ILE A CA  1 
ATOM   2677 C  C   . ILE A 1 378 ? -0.265  -16.576 -44.145 0.50 55.13  ? 641  ILE A C   1 
ATOM   2678 O  O   . ILE A 1 378 ? -1.101  -17.281 -44.740 0.50 56.52  ? 641  ILE A O   1 
ATOM   2679 C  CB  . ILE A 1 378 ? -0.224  -14.148 -44.979 0.50 57.53  ? 641  ILE A CB  1 
ATOM   2680 C  CG1 . ILE A 1 378 ? -0.405  -14.772 -46.366 0.50 56.89  ? 641  ILE A CG1 1 
ATOM   2681 C  CG2 . ILE A 1 378 ? 1.192   -13.642 -44.769 0.50 58.36  ? 641  ILE A CG2 1 
ATOM   2682 C  CD1 . ILE A 1 378 ? 0.805   -15.526 -46.863 0.50 58.49  ? 641  ILE A CD1 1 
ATOM   2683 N  N   . ALA A 1 379 ? 0.931   -17.013 -43.739 1.00 53.66  ? 642  ALA A N   1 
ATOM   2684 C  CA  . ALA A 1 379 ? 1.386   -18.420 -43.889 1.00 52.70  ? 642  ALA A CA  1 
ATOM   2685 C  C   . ALA A 1 379 ? 0.508   -19.363 -43.015 1.00 40.63  ? 642  ALA A C   1 
ATOM   2686 O  O   . ALA A 1 379 ? -0.006  -20.340 -43.550 1.00 42.40  ? 642  ALA A O   1 
ATOM   2687 C  CB  . ALA A 1 379 ? 2.847   -18.507 -43.527 1.00 49.28  ? 642  ALA A CB  1 
ATOM   2688 N  N   . VAL A 1 380 ? 0.302   -18.997 -41.752 1.00 39.18  ? 643  VAL A N   1 
ATOM   2689 C  CA  . VAL A 1 380 ? -0.562  -19.723 -40.775 1.00 44.97  ? 643  VAL A CA  1 
ATOM   2690 C  C   . VAL A 1 380 ? -1.976  -19.779 -41.362 1.00 47.61  ? 643  VAL A C   1 
ATOM   2691 O  O   . VAL A 1 380 ? -2.520  -20.907 -41.536 1.00 39.92  ? 643  VAL A O   1 
ATOM   2692 C  CB  . VAL A 1 380 ? -0.519  -19.062 -39.388 1.00 41.53  ? 643  VAL A CB  1 
ATOM   2693 C  CG1 . VAL A 1 380 ? -1.565  -19.664 -38.464 1.00 46.52  ? 643  VAL A CG1 1 
ATOM   2694 C  CG2 . VAL A 1 380 ? 0.857   -19.187 -38.737 1.00 42.07  ? 643  VAL A CG2 1 
ATOM   2695 N  N   . LYS A 1 381 ? -2.509  -18.614 -41.764 1.00 45.37  ? 644  LYS A N   1 
ATOM   2696 C  CA  . LYS A 1 381 ? -3.864  -18.500 -42.358 1.00 47.23  ? 644  LYS A CA  1 
ATOM   2697 C  C   . LYS A 1 381 ? -3.939  -19.444 -43.557 1.00 45.28  ? 644  LYS A C   1 
ATOM   2698 O  O   . LYS A 1 381 ? -4.929  -20.207 -43.643 1.00 44.93  ? 644  LYS A O   1 
ATOM   2699 C  CB  . LYS A 1 381 ? -4.190  -17.053 -42.752 1.00 57.47  ? 644  LYS A CB  1 
ATOM   2700 C  CG  . LYS A 1 381 ? -5.071  -16.289 -41.768 1.00 70.23  ? 644  LYS A CG  1 
ATOM   2701 C  CD  . LYS A 1 381 ? -4.627  -14.849 -41.508 1.00 75.82  ? 644  LYS A CD  1 
ATOM   2702 C  CE  . LYS A 1 381 ? -5.367  -14.179 -40.364 1.00 79.44  ? 644  LYS A CE  1 
ATOM   2703 N  NZ  . LYS A 1 381 ? -4.542  -13.127 -39.720 1.00 81.43  ? 644  LYS A NZ  1 
ATOM   2704 N  N   . ASN A 1 382 ? -2.910  -19.436 -44.417 1.00 42.11  ? 645  ASN A N   1 
ATOM   2705 C  CA  . ASN A 1 382 ? -2.922  -20.199 -45.695 1.00 45.15  ? 645  ASN A CA  1 
ATOM   2706 C  C   . ASN A 1 382 ? -2.817  -21.704 -45.429 1.00 38.86  ? 645  ASN A C   1 
ATOM   2707 O  O   . ASN A 1 382 ? -3.391  -22.491 -46.215 1.00 39.50  ? 645  ASN A O   1 
ATOM   2708 C  CB  . ASN A 1 382 ? -1.789  -19.795 -46.660 1.00 48.88  ? 645  ASN A CB  1 
ATOM   2709 C  CG  . ASN A 1 382 ? -2.043  -20.301 -48.068 1.00 61.62  ? 645  ASN A CG  1 
ATOM   2710 O  OD1 . ASN A 1 382 ? -3.073  -19.972 -48.658 1.00 77.39  ? 645  ASN A OD1 1 
ATOM   2711 N  ND2 . ASN A 1 382 ? -1.149  -21.121 -48.611 1.00 58.40  ? 645  ASN A ND2 1 
ATOM   2712 N  N   . TRP A 1 383 ? -2.020  -22.095 -44.433 1.00 42.57  ? 646  TRP A N   1 
ATOM   2713 C  CA  . TRP A 1 383 ? -1.895  -23.511 -43.960 1.00 37.46  ? 646  TRP A CA  1 
ATOM   2714 C  C   . TRP A 1 383 ? -3.295  -24.030 -43.552 1.00 32.37  ? 646  TRP A C   1 
ATOM   2715 O  O   . TRP A 1 383 ? -3.784  -25.036 -44.161 1.00 34.27  ? 646  TRP A O   1 
ATOM   2716 C  CB  . TRP A 1 383 ? -0.869  -23.538 -42.828 1.00 34.10  ? 646  TRP A CB  1 
ATOM   2717 C  CG  . TRP A 1 383 ? -0.449  -24.892 -42.341 1.00 41.30  ? 646  TRP A CG  1 
ATOM   2718 C  CD1 . TRP A 1 383 ? 0.578   -25.680 -42.794 1.00 42.78  ? 646  TRP A CD1 1 
ATOM   2719 C  CD2 . TRP A 1 383 ? -1.042  -25.612 -41.244 1.00 38.21  ? 646  TRP A CD2 1 
ATOM   2720 N  NE1 . TRP A 1 383 ? 0.660   -26.839 -42.061 1.00 39.91  ? 646  TRP A NE1 1 
ATOM   2721 C  CE2 . TRP A 1 383 ? -0.308  -26.817 -41.091 1.00 39.19  ? 646  TRP A CE2 1 
ATOM   2722 C  CE3 . TRP A 1 383 ? -2.125  -25.360 -40.403 1.00 32.61  ? 646  TRP A CE3 1 
ATOM   2723 C  CZ2 . TRP A 1 383 ? -0.630  -27.758 -40.111 1.00 37.00  ? 646  TRP A CZ2 1 
ATOM   2724 C  CZ3 . TRP A 1 383 ? -2.416  -26.275 -39.408 1.00 39.11  ? 646  TRP A CZ3 1 
ATOM   2725 C  CH2 . TRP A 1 383 ? -1.687  -27.462 -39.277 1.00 34.67  ? 646  TRP A CH2 1 
ATOM   2726 N  N   . LEU A 1 384 ? -3.975  -23.277 -42.685 1.00 36.44  ? 647  LEU A N   1 
ATOM   2727 C  CA  . LEU A 1 384 ? -5.341  -23.616 -42.186 1.00 41.73  ? 647  LEU A CA  1 
ATOM   2728 C  C   . LEU A 1 384 ? -6.284  -23.831 -43.373 1.00 40.42  ? 647  LEU A C   1 
ATOM   2729 O  O   . LEU A 1 384 ? -6.949  -24.897 -43.466 1.00 38.33  ? 647  LEU A O   1 
ATOM   2730 C  CB  . LEU A 1 384 ? -5.821  -22.508 -41.238 1.00 38.83  ? 647  LEU A CB  1 
ATOM   2731 C  CG  . LEU A 1 384 ? -5.168  -22.511 -39.857 1.00 39.41  ? 647  LEU A CG  1 
ATOM   2732 C  CD1 . LEU A 1 384 ? -5.629  -21.336 -39.022 1.00 40.33  ? 647  LEU A CD1 1 
ATOM   2733 C  CD2 . LEU A 1 384 ? -5.420  -23.801 -39.084 1.00 39.77  ? 647  LEU A CD2 1 
ATOM   2734 N  N   . VAL A 1 385 ? -6.308  -22.868 -44.298 1.00 44.92  ? 648  VAL A N   1 
ATOM   2735 C  CA  . VAL A 1 385 ? -7.242  -22.866 -45.449 1.00 42.54  ? 648  VAL A CA  1 
ATOM   2736 C  C   . VAL A 1 385 ? -6.861  -24.034 -46.342 1.00 39.60  ? 648  VAL A C   1 
ATOM   2737 O  O   . VAL A 1 385 ? -7.756  -24.761 -46.765 1.00 41.32  ? 648  VAL A O   1 
ATOM   2738 C  CB  . VAL A 1 385 ? -7.185  -21.515 -46.200 1.00 51.91  ? 648  VAL A CB  1 
ATOM   2739 C  CG1 . VAL A 1 385 ? -7.883  -21.590 -47.537 1.00 49.90  ? 648  VAL A CG1 1 
ATOM   2740 C  CG2 . VAL A 1 385 ? -7.768  -20.388 -45.357 1.00 54.72  ? 648  VAL A CG2 1 
ATOM   2741 N  N   . ARG A 1 386 ? -5.564  -24.236 -46.550 1.00 40.24  ? 649  ARG A N   1 
ATOM   2742 C  CA  . ARG A 1 386 ? -5.036  -25.256 -47.483 1.00 43.78  ? 649  ARG A CA  1 
ATOM   2743 C  C   . ARG A 1 386 ? -5.099  -26.656 -46.847 1.00 43.89  ? 649  ARG A C   1 
ATOM   2744 O  O   . ARG A 1 386 ? -5.532  -27.601 -47.550 1.00 42.07  ? 649  ARG A O   1 
ATOM   2745 C  CB  . ARG A 1 386 ? -3.612  -24.846 -47.889 1.00 54.30  ? 649  ARG A CB  1 
ATOM   2746 C  CG  . ARG A 1 386 ? -2.979  -25.691 -48.989 1.00 63.39  ? 649  ARG A CG  1 
ATOM   2747 C  CD  . ARG A 1 386 ? -1.548  -25.252 -49.341 1.00 68.22  ? 649  ARG A CD  1 
ATOM   2748 N  NE  . ARG A 1 386 ? -0.492  -25.733 -48.434 1.00 63.51  ? 649  ARG A NE  1 
ATOM   2749 C  CZ  . ARG A 1 386 ? 0.146   -25.007 -47.499 1.00 58.77  ? 649  ARG A CZ  1 
ATOM   2750 N  NH1 . ARG A 1 386 ? -0.118  -23.723 -47.309 1.00 60.95  ? 649  ARG A NH1 1 
ATOM   2751 N  NH2 . ARG A 1 386 ? 1.088   -25.575 -46.770 1.00 60.26  ? 649  ARG A NH2 1 
ATOM   2752 N  N   . VAL A 1 387 ? -4.674  -26.833 -45.588 1.00 40.31  ? 650  VAL A N   1 
ATOM   2753 C  CA  . VAL A 1 387 ? -4.539  -28.237 -45.078 1.00 41.73  ? 650  VAL A CA  1 
ATOM   2754 C  C   . VAL A 1 387 ? -5.253  -28.448 -43.733 1.00 39.07  ? 650  VAL A C   1 
ATOM   2755 O  O   . VAL A 1 387 ? -5.187  -29.614 -43.263 1.00 33.44  ? 650  VAL A O   1 
ATOM   2756 C  CB  . VAL A 1 387 ? -3.064  -28.669 -44.961 1.00 37.08  ? 650  VAL A CB  1 
ATOM   2757 C  CG1 . VAL A 1 387 ? -2.394  -28.803 -46.325 1.00 42.15  ? 650  VAL A CG1 1 
ATOM   2758 C  CG2 . VAL A 1 387 ? -2.296  -27.761 -44.019 1.00 36.25  ? 650  VAL A CG2 1 
ATOM   2759 N  N   . GLY A 1 388 ? -5.878  -27.411 -43.170 1.00 34.92  ? 651  GLY A N   1 
ATOM   2760 C  CA  . GLY A 1 388 ? -6.513  -27.410 -41.834 1.00 36.99  ? 651  GLY A CA  1 
ATOM   2761 C  C   . GLY A 1 388 ? -7.396  -28.629 -41.637 1.00 36.55  ? 651  GLY A C   1 
ATOM   2762 O  O   . GLY A 1 388 ? -7.218  -29.333 -40.623 1.00 34.57  ? 651  GLY A O   1 
ATOM   2763 N  N   . ARG A 1 389 ? -8.296  -28.894 -42.575 1.00 34.28  ? 652  ARG A N   1 
ATOM   2764 C  CA  . ARG A 1 389 ? -9.285  -29.994 -42.461 1.00 35.66  ? 652  ARG A CA  1 
ATOM   2765 C  C   . ARG A 1 389 ? -8.554  -31.347 -42.456 1.00 34.77  ? 652  ARG A C   1 
ATOM   2766 O  O   . ARG A 1 389 ? -8.909  -32.223 -41.658 1.00 32.72  ? 652  ARG A O   1 
ATOM   2767 C  CB  . ARG A 1 389 ? -10.374 -29.885 -43.534 1.00 35.66  ? 652  ARG A CB  1 
ATOM   2768 C  CG  . ARG A 1 389 ? -11.335 -28.732 -43.297 1.00 38.74  ? 652  ARG A CG  1 
ATOM   2769 C  CD  . ARG A 1 389 ? -12.379 -28.691 -44.396 1.00 38.76  ? 652  ARG A CD  1 
ATOM   2770 N  NE  . ARG A 1 389 ? -13.345 -29.782 -44.308 1.00 39.19  ? 652  ARG A NE  1 
ATOM   2771 C  CZ  . ARG A 1 389 ? -14.379 -29.793 -43.453 1.00 34.87  ? 652  ARG A CZ  1 
ATOM   2772 N  NH1 . ARG A 1 389 ? -14.578 -28.782 -42.620 1.00 39.04  ? 652  ARG A NH1 1 
ATOM   2773 N  NH2 . ARG A 1 389 ? -15.191 -30.831 -43.429 1.00 38.94  ? 652  ARG A NH2 1 
ATOM   2774 N  N   . GLU A 1 390 ? -7.589  -31.536 -43.361 0.50 32.57  ? 653  GLU A N   1 
ATOM   2775 C  CA  . GLU A 1 390 ? -6.810  -32.801 -43.473 0.50 34.01  ? 653  GLU A CA  1 
ATOM   2776 C  C   . GLU A 1 390 ? -6.054  -33.074 -42.160 0.50 30.92  ? 653  GLU A C   1 
ATOM   2777 O  O   . GLU A 1 390 ? -5.960  -34.276 -41.760 0.50 31.35  ? 653  GLU A O   1 
ATOM   2778 C  CB  . GLU A 1 390 ? -5.819  -32.744 -44.638 0.50 34.88  ? 653  GLU A CB  1 
ATOM   2779 C  CG  . GLU A 1 390 ? -5.088  -34.054 -44.863 0.50 36.09  ? 653  GLU A CG  1 
ATOM   2780 C  CD  . GLU A 1 390 ? -3.930  -34.357 -43.914 0.50 37.52  ? 653  GLU A CD  1 
ATOM   2781 O  OE1 . GLU A 1 390 ? -3.566  -33.480 -43.072 0.50 38.39  ? 653  GLU A OE1 1 
ATOM   2782 O  OE2 . GLU A 1 390 ? -3.389  -35.476 -44.024 0.50 38.35  ? 653  GLU A OE2 1 
ATOM   2783 N  N   . ARG A 1 391 ? -5.568  -32.006 -41.511 0.50 29.46  ? 654  ARG A N   1 
ATOM   2784 C  CA  . ARG A 1 391 ? -4.790  -32.084 -40.247 0.50 29.27  ? 654  ARG A CA  1 
ATOM   2785 C  C   . ARG A 1 391 ? -5.742  -32.452 -39.096 0.50 27.32  ? 654  ARG A C   1 
ATOM   2786 O  O   . ARG A 1 391 ? -5.375  -33.334 -38.276 0.50 23.72  ? 654  ARG A O   1 
ATOM   2787 C  CB  . ARG A 1 391 ? -4.039  -30.775 -39.990 0.50 30.14  ? 654  ARG A CB  1 
ATOM   2788 C  CG  . ARG A 1 391 ? -2.977  -30.444 -41.033 0.50 30.60  ? 654  ARG A CG  1 
ATOM   2789 C  CD  . ARG A 1 391 ? -1.778  -31.377 -41.041 0.50 31.58  ? 654  ARG A CD  1 
ATOM   2790 N  NE  . ARG A 1 391 ? -0.678  -30.765 -41.770 0.50 32.25  ? 654  ARG A NE  1 
ATOM   2791 C  CZ  . ARG A 1 391 ? -0.574  -30.757 -43.093 0.50 31.74  ? 654  ARG A CZ  1 
ATOM   2792 N  NH1 . ARG A 1 391 ? -1.476  -31.369 -43.837 0.50 31.12  ? 654  ARG A NH1 1 
ATOM   2793 N  NH2 . ARG A 1 391 ? 0.447   -30.158 -43.672 0.50 30.16  ? 654  ARG A NH2 1 
ATOM   2794 N  N   . LEU A 1 392 ? -6.935  -31.846 -39.068 1.00 26.98  ? 655  LEU A N   1 
ATOM   2795 C  CA  . LEU A 1 392 ? -7.972  -32.159 -38.028 1.00 26.33  ? 655  LEU A CA  1 
ATOM   2796 C  C   . LEU A 1 392 ? -8.283  -33.654 -38.102 1.00 27.59  ? 655  LEU A C   1 
ATOM   2797 O  O   . LEU A 1 392 ? -8.413  -34.307 -37.028 1.00 26.84  ? 655  LEU A O   1 
ATOM   2798 C  CB  . LEU A 1 392 ? -9.250  -31.350 -38.256 1.00 28.84  ? 655  LEU A CB  1 
ATOM   2799 C  CG  . LEU A 1 392 ? -9.251  -29.887 -37.859 1.00 27.60  ? 655  LEU A CG  1 
ATOM   2800 C  CD1 . LEU A 1 392 ? -10.621 -29.284 -38.208 1.00 30.32  ? 655  LEU A CD1 1 
ATOM   2801 C  CD2 . LEU A 1 392 ? -8.924  -29.683 -36.387 1.00 27.69  ? 655  LEU A CD2 1 
ATOM   2802 N  N   . SER A 1 393 ? -8.334  -34.203 -39.308 1.00 28.38  ? 656  SER A N   1 
ATOM   2803 C  CA  . SER A 1 393 ? -8.665  -35.618 -39.544 1.00 28.94  ? 656  SER A CA  1 
ATOM   2804 C  C   . SER A 1 393 ? -7.565  -36.552 -39.053 1.00 27.89  ? 656  SER A C   1 
ATOM   2805 O  O   . SER A 1 393 ? -7.795  -37.732 -39.021 1.00 25.73  ? 656  SER A O   1 
ATOM   2806 C  CB  . SER A 1 393 ? -9.026  -35.901 -40.982 1.00 32.25  ? 656  SER A CB  1 
ATOM   2807 O  OG  . SER A 1 393 ? -7.869  -35.943 -41.831 1.00 37.47  ? 656  SER A OG  1 
ATOM   2808 N  N   . ARG A 1 394 ? -6.362  -36.030 -38.769 0.50 26.08  ? 657  ARG A N   1 
ATOM   2809 C  CA  . ARG A 1 394 ? -5.208  -36.841 -38.310 0.50 25.33  ? 657  ARG A CA  1 
ATOM   2810 C  C   . ARG A 1 394 ? -5.276  -36.970 -36.790 0.50 24.85  ? 657  ARG A C   1 
ATOM   2811 O  O   . ARG A 1 394 ? -4.245  -37.344 -36.174 0.50 24.57  ? 657  ARG A O   1 
ATOM   2812 C  CB  . ARG A 1 394 ? -3.888  -36.185 -38.730 0.50 26.18  ? 657  ARG A CB  1 
ATOM   2813 C  CG  . ARG A 1 394 ? -3.540  -36.381 -40.196 0.50 27.43  ? 657  ARG A CG  1 
ATOM   2814 C  CD  . ARG A 1 394 ? -2.297  -35.618 -40.624 0.50 28.02  ? 657  ARG A CD  1 
ATOM   2815 N  NE  . ARG A 1 394 ? -1.936  -36.122 -41.935 0.50 28.05  ? 657  ARG A NE  1 
ATOM   2816 C  CZ  . ARG A 1 394 ? -1.147  -37.158 -42.137 0.50 30.13  ? 657  ARG A CZ  1 
ATOM   2817 N  NH1 . ARG A 1 394 ? -0.559  -37.754 -41.111 0.50 30.22  ? 657  ARG A NH1 1 
ATOM   2818 N  NH2 . ARG A 1 394 ? -0.916  -37.569 -43.371 0.50 30.20  ? 657  ARG A NH2 1 
ATOM   2819 N  N   . MET A 1 395 ? -6.432  -36.657 -36.195 0.50 24.26  ? 658  MET A N   1 
ATOM   2820 C  CA  . MET A 1 395 ? -6.558  -36.586 -34.724 0.50 22.95  ? 658  MET A CA  1 
ATOM   2821 C  C   . MET A 1 395 ? -7.885  -37.181 -34.228 0.50 23.26  ? 658  MET A C   1 
ATOM   2822 O  O   . MET A 1 395 ? -8.859  -37.269 -35.008 0.50 21.09  ? 658  MET A O   1 
ATOM   2823 C  CB  . MET A 1 395 ? -6.430  -35.132 -34.271 0.50 23.99  ? 658  MET A CB  1 
ATOM   2824 C  CG  . MET A 1 395 ? -5.269  -34.413 -34.941 0.50 24.77  ? 658  MET A CG  1 
ATOM   2825 S  SD  . MET A 1 395 ? -4.826  -32.883 -34.105 0.50 24.25  ? 658  MET A SD  1 
ATOM   2826 C  CE  . MET A 1 395 ? -6.059  -31.768 -34.770 0.50 24.25  ? 658  MET A CE  1 
ATOM   2827 N  N   . ALA A 1 396 ? -7.874  -37.599 -32.961 1.00 22.92  ? 659  ALA A N   1 
ATOM   2828 C  CA  . ALA A 1 396 ? -9.059  -38.039 -32.200 1.00 22.05  ? 659  ALA A CA  1 
ATOM   2829 C  C   . ALA A 1 396 ? -8.973  -37.322 -30.859 1.00 22.53  ? 659  ALA A C   1 
ATOM   2830 O  O   . ALA A 1 396 ? -8.020  -37.523 -30.103 1.00 20.95  ? 659  ALA A O   1 
ATOM   2831 C  CB  . ALA A 1 396 ? -9.085  -39.531 -32.058 1.00 22.15  ? 659  ALA A CB  1 
ATOM   2832 N  N   . ILE A 1 397 ? -9.930  -36.446 -30.582 1.00 21.06  ? 660  ILE A N   1 
ATOM   2833 C  CA  . ILE A 1 397 ? -9.900  -35.558 -29.414 1.00 20.86  ? 660  ILE A CA  1 
ATOM   2834 C  C   . ILE A 1 397 ? -11.237 -35.630 -28.666 1.00 24.46  ? 660  ILE A C   1 
ATOM   2835 O  O   . ILE A 1 397 ? -12.308 -35.379 -29.253 1.00 22.76  ? 660  ILE A O   1 
ATOM   2836 C  CB  . ILE A 1 397 ? -9.574  -34.145 -29.872 1.00 22.45  ? 660  ILE A CB  1 
ATOM   2837 C  CG1 . ILE A 1 397 ? -8.246  -34.141 -30.636 1.00 26.82  ? 660  ILE A CG1 1 
ATOM   2838 C  CG2 . ILE A 1 397 ? -9.614  -33.215 -28.679 1.00 24.87  ? 660  ILE A CG2 1 
ATOM   2839 C  CD1 . ILE A 1 397 ? -7.664  -32.773 -30.934 1.00 28.87  ? 660  ILE A CD1 1 
ATOM   2840 N  N   . SER A 1 398 ? -11.128 -36.002 -27.401 1.00 22.63  ? 661  SER A N   1 
ATOM   2841 C  CA  . SER A 1 398 ? -12.247 -36.159 -26.450 1.00 24.42  ? 661  SER A CA  1 
ATOM   2842 C  C   . SER A 1 398 ? -11.959 -35.289 -25.247 1.00 25.04  ? 661  SER A C   1 
ATOM   2843 O  O   . SER A 1 398 ? -11.207 -35.736 -24.340 1.00 24.22  ? 661  SER A O   1 
ATOM   2844 C  CB  . SER A 1 398 ? -12.458 -37.583 -26.063 1.00 26.32  ? 661  SER A CB  1 
ATOM   2845 O  OG  . SER A 1 398 ? -13.714 -37.684 -25.455 1.00 26.37  ? 661  SER A OG  1 
ATOM   2846 N  N   . GLY A 1 399 ? -12.428 -34.039 -25.288 1.00 25.39  ? 662  GLY A N   1 
ATOM   2847 C  CA  . GLY A 1 399 ? -12.100 -33.107 -24.195 1.00 25.87  ? 662  GLY A CA  1 
ATOM   2848 C  C   . GLY A 1 399 ? -10.596 -32.938 -24.039 1.00 26.08  ? 662  GLY A C   1 
ATOM   2849 O  O   . GLY A 1 399 ? -9.920  -32.582 -25.048 1.00 26.47  ? 662  GLY A O   1 
ATOM   2850 N  N   . ASP A 1 400 ? -10.034 -33.192 -22.853 1.00 25.69  ? 663  ASP A N   1 
ATOM   2851 C  CA  . ASP A 1 400 ? -8.569  -32.995 -22.662 1.00 28.60  ? 663  ASP A CA  1 
ATOM   2852 C  C   . ASP A 1 400 ? -7.757  -34.178 -23.194 1.00 28.10  ? 663  ASP A C   1 
ATOM   2853 O  O   . ASP A 1 400 ? -6.506  -34.119 -23.186 1.00 28.10  ? 663  ASP A O   1 
ATOM   2854 C  CB  . ASP A 1 400 ? -8.227  -32.706 -21.199 1.00 32.86  ? 663  ASP A CB  1 
ATOM   2855 C  CG  . ASP A 1 400 ? -8.599  -33.830 -20.243 1.00 38.42  ? 663  ASP A CG  1 
ATOM   2856 O  OD1 . ASP A 1 400 ? -9.188  -34.800 -20.668 1.00 38.97  ? 663  ASP A OD1 1 
ATOM   2857 O  OD2 . ASP A 1 400 ? -8.246  -33.729 -19.084 1.00 45.81  ? 663  ASP A OD2 1 
ATOM   2858 N  N   . ASP A 1 401 ? -8.389  -35.174 -23.753 1.00 24.75  ? 664  ASP A N   1 
ATOM   2859 C  CA  . ASP A 1 401 ? -7.686  -36.394 -24.223 1.00 23.97  ? 664  ASP A CA  1 
ATOM   2860 C  C   . ASP A 1 401 ? -7.477  -36.327 -25.717 1.00 24.52  ? 664  ASP A C   1 
ATOM   2861 O  O   . ASP A 1 401 ? -8.468  -36.011 -26.442 1.00 29.06  ? 664  ASP A O   1 
ATOM   2862 C  CB  . ASP A 1 401 ? -8.501  -37.626 -23.806 1.00 26.07  ? 664  ASP A CB  1 
ATOM   2863 C  CG  . ASP A 1 401 ? -7.630  -38.855 -23.709 1.00 33.72  ? 664  ASP A CG  1 
ATOM   2864 O  OD1 . ASP A 1 401 ? -6.435  -38.668 -23.860 1.00 32.63  ? 664  ASP A OD1 1 
ATOM   2865 O  OD2 . ASP A 1 401 ? -8.146  -39.928 -23.452 1.00 34.46  ? 664  ASP A OD2 1 
ATOM   2866 N  N   . CYS A 1 402 ? -6.262  -36.567 -26.216 1.00 24.69  ? 665  CYS A N   1 
ATOM   2867 C  CA  . CYS A 1 402 ? -5.999  -36.552 -27.672 1.00 23.81  ? 665  CYS A CA  1 
ATOM   2868 C  C   . CYS A 1 402 ? -5.122  -37.705 -28.111 1.00 24.80  ? 665  CYS A C   1 
ATOM   2869 O  O   . CYS A 1 402 ? -4.267  -38.182 -27.326 1.00 25.23  ? 665  CYS A O   1 
ATOM   2870 C  CB  . CYS A 1 402 ? -5.370  -35.245 -28.123 1.00 29.87  ? 665  CYS A CB  1 
ATOM   2871 S  SG  . CYS A 1 402 ? -3.770  -34.935 -27.340 1.00 34.58  ? 665  CYS A SG  1 
ATOM   2872 N  N   . VAL A 1 403 ? -5.289  -38.053 -29.371 1.00 20.56  ? 666  VAL A N   1 
ATOM   2873 C  CA  . VAL A 1 403 ? -4.343  -38.880 -30.177 1.00 23.51  ? 666  VAL A CA  1 
ATOM   2874 C  C   . VAL A 1 403 ? -4.097  -38.096 -31.461 1.00 24.75  ? 666  VAL A C   1 
ATOM   2875 O  O   . VAL A 1 403 ? -5.080  -37.593 -32.065 1.00 24.01  ? 666  VAL A O   1 
ATOM   2876 C  CB  . VAL A 1 403 ? -4.896  -40.286 -30.456 1.00 23.35  ? 666  VAL A CB  1 
ATOM   2877 C  CG1 . VAL A 1 403 ? -3.984  -41.107 -31.332 1.00 26.14  ? 666  VAL A CG1 1 
ATOM   2878 C  CG2 . VAL A 1 403 ? -5.217  -41.006 -29.136 1.00 25.03  ? 666  VAL A CG2 1 
ATOM   2879 N  N   . VAL A 1 404 ? -2.837  -37.936 -31.825 1.00 23.11  ? 667  VAL A N   1 
ATOM   2880 C  CA  . VAL A 1 404 ? -2.430  -37.118 -33.001 1.00 22.09  ? 667  VAL A CA  1 
ATOM   2881 C  C   . VAL A 1 404 ? -1.498  -37.982 -33.830 1.00 22.24  ? 667  VAL A C   1 
ATOM   2882 O  O   . VAL A 1 404 ? -0.515  -38.512 -33.256 1.00 25.43  ? 667  VAL A O   1 
ATOM   2883 C  CB  . VAL A 1 404 ? -1.759  -35.779 -32.614 1.00 25.02  ? 667  VAL A CB  1 
ATOM   2884 C  CG1 . VAL A 1 404 ? -1.402  -34.974 -33.858 1.00 25.05  ? 667  VAL A CG1 1 
ATOM   2885 C  CG2 . VAL A 1 404 ? -2.598  -34.903 -31.676 1.00 26.75  ? 667  VAL A CG2 1 
ATOM   2886 N  N   . LYS A 1 405 ? -1.780  -38.178 -35.100 1.00 22.31  ? 668  LYS A N   1 
ATOM   2887 C  CA  . LYS A 1 405 ? -0.812  -38.775 -36.074 1.00 24.06  ? 668  LYS A CA  1 
ATOM   2888 C  C   . LYS A 1 405 ? -0.296  -37.675 -37.003 1.00 26.41  ? 668  LYS A C   1 
ATOM   2889 O  O   . LYS A 1 405 ? -0.882  -37.414 -38.048 1.00 25.41  ? 668  LYS A O   1 
ATOM   2890 C  CB  . LYS A 1 405 ? -1.345  -39.898 -36.931 1.00 24.78  ? 668  LYS A CB  1 
ATOM   2891 C  CG  . LYS A 1 405 ? -0.225  -40.612 -37.678 1.00 27.57  ? 668  LYS A CG  1 
ATOM   2892 C  CD  . LYS A 1 405 ? -0.501  -41.931 -38.259 1.00 30.39  ? 668  LYS A CD  1 
ATOM   2893 C  CE  . LYS A 1 405 ? 0.780   -42.477 -38.876 1.00 33.82  ? 668  LYS A CE  1 
ATOM   2894 N  NZ  . LYS A 1 405 ? 0.559   -43.740 -39.581 1.00 35.48  ? 668  LYS A NZ  1 
ATOM   2895 N  N   . PRO A 1 406 ? 0.793   -36.988 -36.615 1.00 25.92  ? 669  PRO A N   1 
ATOM   2896 C  CA  . PRO A 1 406 ? 1.305   -35.874 -37.420 1.00 26.78  ? 669  PRO A CA  1 
ATOM   2897 C  C   . PRO A 1 406 ? 1.943   -36.329 -38.734 1.00 26.19  ? 669  PRO A C   1 
ATOM   2898 O  O   . PRO A 1 406 ? 2.157   -37.495 -38.979 1.00 25.72  ? 669  PRO A O   1 
ATOM   2899 C  CB  . PRO A 1 406 ? 2.252   -35.207 -36.426 1.00 25.58  ? 669  PRO A CB  1 
ATOM   2900 C  CG  . PRO A 1 406 ? 2.851   -36.394 -35.715 1.00 28.76  ? 669  PRO A CG  1 
ATOM   2901 C  CD  . PRO A 1 406 ? 1.631   -37.253 -35.443 1.00 24.74  ? 669  PRO A CD  1 
ATOM   2902 N  N   . LEU A 1 407 ? 2.246   -35.349 -39.586 1.00 29.93  ? 670  LEU A N   1 
ATOM   2903 C  CA  . LEU A 1 407 ? 2.912   -35.564 -40.896 1.00 32.58  ? 670  LEU A CA  1 
ATOM   2904 C  C   . LEU A 1 407 ? 4.233   -36.341 -40.702 1.00 29.10  ? 670  LEU A C   1 
ATOM   2905 O  O   . LEU A 1 407 ? 4.494   -37.202 -41.500 1.00 31.49  ? 670  LEU A O   1 
ATOM   2906 C  CB  . LEU A 1 407 ? 3.118   -34.181 -41.545 1.00 33.42  ? 670  LEU A CB  1 
ATOM   2907 C  CG  . LEU A 1 407 ? 3.151   -34.156 -43.065 1.00 42.12  ? 670  LEU A CG  1 
ATOM   2908 C  CD1 . LEU A 1 407 ? 1.799   -34.502 -43.663 1.00 42.18  ? 670  LEU A CD1 1 
ATOM   2909 C  CD2 . LEU A 1 407 ? 3.606   -32.781 -43.550 1.00 44.88  ? 670  LEU A CD2 1 
ATOM   2910 N  N   . ASP A 1 408 ? 4.976   -36.106 -39.625 1.00 30.26  ? 671  ASP A N   1 
ATOM   2911 C  CA  . ASP A 1 408 ? 6.261   -36.796 -39.343 1.00 32.92  ? 671  ASP A CA  1 
ATOM   2912 C  C   . ASP A 1 408 ? 6.600   -36.619 -37.870 1.00 31.11  ? 671  ASP A C   1 
ATOM   2913 O  O   . ASP A 1 408 ? 5.841   -35.970 -37.114 1.00 35.25  ? 671  ASP A O   1 
ATOM   2914 C  CB  . ASP A 1 408 ? 7.359   -36.277 -40.299 1.00 33.91  ? 671  ASP A CB  1 
ATOM   2915 C  CG  . ASP A 1 408 ? 7.432   -34.761 -40.317 1.00 30.96  ? 671  ASP A CG  1 
ATOM   2916 O  OD1 . ASP A 1 408 ? 7.710   -34.182 -39.244 1.00 34.57  ? 671  ASP A OD1 1 
ATOM   2917 O  OD2 . ASP A 1 408 ? 7.066   -34.155 -41.355 1.00 37.72  ? 671  ASP A OD2 1 
ATOM   2918 N  N   . ASP A 1 409 ? 7.766   -37.083 -37.445 1.00 27.45  ? 672  ASP A N   1 
ATOM   2919 C  CA  . ASP A 1 409 ? 8.115   -37.058 -36.006 1.00 27.54  ? 672  ASP A CA  1 
ATOM   2920 C  C   . ASP A 1 409 ? 8.788   -35.753 -35.562 1.00 27.09  ? 672  ASP A C   1 
ATOM   2921 O  O   . ASP A 1 409 ? 9.131   -35.646 -34.380 1.00 27.75  ? 672  ASP A O   1 
ATOM   2922 C  CB  . ASP A 1 409 ? 8.884   -38.328 -35.679 1.00 32.25  ? 672  ASP A CB  1 
ATOM   2923 C  CG  . ASP A 1 409 ? 8.023   -39.562 -35.853 1.00 36.05  ? 672  ASP A CG  1 
ATOM   2924 O  OD1 . ASP A 1 409 ? 6.901   -39.586 -35.276 1.00 35.56  ? 672  ASP A OD1 1 
ATOM   2925 O  OD2 . ASP A 1 409 ? 8.453   -40.460 -36.565 1.00 37.01  ? 672  ASP A OD2 1 
ATOM   2926 N  N   . ARG A 1 410 ? 8.878   -34.715 -36.393 1.00 30.57  ? 673  ARG A N   1 
ATOM   2927 C  CA  . ARG A 1 410 ? 9.344   -33.394 -35.873 1.00 31.24  ? 673  ARG A CA  1 
ATOM   2928 C  C   . ARG A 1 410 ? 8.386   -32.920 -34.784 1.00 30.29  ? 673  ARG A C   1 
ATOM   2929 O  O   . ARG A 1 410 ? 8.808   -32.235 -33.898 1.00 28.36  ? 673  ARG A O   1 
ATOM   2930 C  CB  . ARG A 1 410 ? 9.426   -32.318 -36.962 1.00 34.55  ? 673  ARG A CB  1 
ATOM   2931 C  CG  . ARG A 1 410 ? 10.494  -32.533 -38.031 1.00 34.52  ? 673  ARG A CG  1 
ATOM   2932 C  CD  . ARG A 1 410 ? 10.275  -31.514 -39.147 1.00 33.14  ? 673  ARG A CD  1 
ATOM   2933 N  NE  . ARG A 1 410 ? 9.084   -31.806 -39.944 1.00 31.42  ? 673  ARG A NE  1 
ATOM   2934 C  CZ  . ARG A 1 410 ? 8.568   -31.012 -40.872 1.00 34.91  ? 673  ARG A CZ  1 
ATOM   2935 N  NH1 . ARG A 1 410 ? 9.146   -29.847 -41.129 1.00 34.39  ? 673  ARG A NH1 1 
ATOM   2936 N  NH2 . ARG A 1 410 ? 7.503   -31.397 -41.572 1.00 35.60  ? 673  ARG A NH2 1 
ATOM   2937 N  N   . PHE A 1 411 ? 7.101   -33.324 -34.842 1.00 28.62  ? 674  PHE A N   1 
ATOM   2938 C  CA  . PHE A 1 411 ? 6.072   -33.099 -33.801 1.00 26.75  ? 674  PHE A CA  1 
ATOM   2939 C  C   . PHE A 1 411 ? 6.583   -33.455 -32.419 1.00 25.12  ? 674  PHE A C   1 
ATOM   2940 O  O   . PHE A 1 411 ? 6.268   -32.692 -31.505 1.00 29.33  ? 674  PHE A O   1 
ATOM   2941 C  CB  . PHE A 1 411 ? 4.809   -33.901 -34.178 1.00 26.27  ? 674  PHE A CB  1 
ATOM   2942 C  CG  . PHE A 1 411 ? 3.625   -33.721 -33.263 1.00 27.03  ? 674  PHE A CG  1 
ATOM   2943 C  CD1 . PHE A 1 411 ? 3.441   -34.524 -32.155 1.00 26.52  ? 674  PHE A CD1 1 
ATOM   2944 C  CD2 . PHE A 1 411 ? 2.631   -32.814 -33.592 1.00 27.18  ? 674  PHE A CD2 1 
ATOM   2945 C  CE1 . PHE A 1 411 ? 2.301   -34.381 -31.357 1.00 27.67  ? 674  PHE A CE1 1 
ATOM   2946 C  CE2 . PHE A 1 411 ? 1.511   -32.645 -32.784 1.00 25.62  ? 674  PHE A CE2 1 
ATOM   2947 C  CZ  . PHE A 1 411 ? 1.345   -33.421 -31.665 1.00 26.30  ? 674  PHE A CZ  1 
ATOM   2948 N  N   . ALA A 1 412 ? 7.346   -34.561 -32.241 1.00 27.63  ? 675  ALA A N   1 
ATOM   2949 C  CA  . ALA A 1 412 ? 7.783   -35.047 -30.912 1.00 30.73  ? 675  ALA A CA  1 
ATOM   2950 C  C   . ALA A 1 412 ? 8.537   -33.979 -30.110 1.00 32.14  ? 675  ALA A C   1 
ATOM   2951 O  O   . ALA A 1 412 ? 8.354   -33.926 -28.894 1.00 28.91  ? 675  ALA A O   1 
ATOM   2952 C  CB  . ALA A 1 412 ? 8.641   -36.285 -31.075 1.00 32.15  ? 675  ALA A CB  1 
ATOM   2953 N  N   . SER A 1 413 ? 9.342   -33.130 -30.771 1.00 34.02  ? 676  SER A N   1 
ATOM   2954 C  CA  . SER A 1 413 ? 10.171  -32.094 -30.089 1.00 34.22  ? 676  SER A CA  1 
ATOM   2955 C  C   . SER A 1 413 ? 9.634   -30.688 -30.361 1.00 39.96  ? 676  SER A C   1 
ATOM   2956 O  O   . SER A 1 413 ? 10.350  -29.716 -30.044 1.00 36.24  ? 676  SER A O   1 
ATOM   2957 C  CB  . SER A 1 413 ? 11.655  -32.214 -30.472 1.00 36.74  ? 676  SER A CB  1 
ATOM   2958 O  OG  . SER A 1 413 ? 11.800  -32.380 -31.871 1.00 38.63  ? 676  SER A OG  1 
ATOM   2959 N  N   . ALA A 1 414 ? 8.403   -30.550 -30.873 1.00 37.14  ? 677  ALA A N   1 
ATOM   2960 C  CA  . ALA A 1 414 ? 7.777   -29.240 -31.165 1.00 37.53  ? 677  ALA A CA  1 
ATOM   2961 C  C   . ALA A 1 414 ? 6.990   -28.850 -29.918 1.00 38.83  ? 677  ALA A C   1 
ATOM   2962 O  O   . ALA A 1 414 ? 5.783   -29.235 -29.830 1.00 36.05  ? 677  ALA A O   1 
ATOM   2963 C  CB  . ALA A 1 414 ? 6.927   -29.326 -32.413 1.00 34.54  ? 677  ALA A CB  1 
ATOM   2964 N  N   . LEU A 1 415 ? 7.661   -28.254 -28.932 1.00 31.75  ? 678  LEU A N   1 
ATOM   2965 C  CA  . LEU A 1 415 ? 7.133   -28.104 -27.554 1.00 33.42  ? 678  LEU A CA  1 
ATOM   2966 C  C   . LEU A 1 415 ? 6.990   -26.639 -27.108 1.00 34.77  ? 678  LEU A C   1 
ATOM   2967 O  O   . LEU A 1 415 ? 6.420   -26.441 -26.010 1.00 39.03  ? 678  LEU A O   1 
ATOM   2968 C  CB  . LEU A 1 415 ? 8.046   -28.870 -26.603 1.00 32.91  ? 678  LEU A CB  1 
ATOM   2969 C  CG  . LEU A 1 415 ? 8.188   -30.373 -26.887 1.00 34.94  ? 678  LEU A CG  1 
ATOM   2970 C  CD1 . LEU A 1 415 ? 9.357   -30.970 -26.114 1.00 37.68  ? 678  LEU A CD1 1 
ATOM   2971 C  CD2 . LEU A 1 415 ? 6.893   -31.109 -26.557 1.00 33.83  ? 678  LEU A CD2 1 
ATOM   2972 N  N   . THR A 1 416 ? 7.434   -25.649 -27.885 1.00 37.01  ? 679  THR A N   1 
ATOM   2973 C  CA  . THR A 1 416 ? 7.506   -24.247 -27.376 1.00 38.85  ? 679  THR A CA  1 
ATOM   2974 C  C   . THR A 1 416 ? 6.089   -23.667 -27.249 1.00 35.59  ? 679  THR A C   1 
ATOM   2975 O  O   . THR A 1 416 ? 5.760   -23.160 -26.158 1.00 38.65  ? 679  THR A O   1 
ATOM   2976 C  CB  . THR A 1 416 ? 8.437   -23.363 -28.212 1.00 34.45  ? 679  THR A CB  1 
ATOM   2977 O  OG1 . THR A 1 416 ? 7.983   -23.212 -29.555 1.00 41.47  ? 679  THR A OG1 1 
ATOM   2978 C  CG2 . THR A 1 416 ? 9.846   -23.909 -28.278 1.00 40.00  ? 679  THR A CG2 1 
ATOM   2979 N  N   . ALA A 1 417 ? 5.265   -23.769 -28.291 1.00 36.84  ? 680  ALA A N   1 
ATOM   2980 C  CA  . ALA A 1 417 ? 3.858   -23.285 -28.242 1.00 36.72  ? 680  ALA A CA  1 
ATOM   2981 C  C   . ALA A 1 417 ? 3.089   -24.091 -27.183 1.00 39.91  ? 680  ALA A C   1 
ATOM   2982 O  O   . ALA A 1 417 ? 2.449   -23.441 -26.298 1.00 38.52  ? 680  ALA A O   1 
ATOM   2983 C  CB  . ALA A 1 417 ? 3.235   -23.300 -29.615 1.00 36.83  ? 680  ALA A CB  1 
ATOM   2984 N  N   . LEU A 1 418 ? 3.190   -25.435 -27.187 1.00 36.57  ? 681  LEU A N   1 
ATOM   2985 C  CA  . LEU A 1 418 ? 2.435   -26.273 -26.221 1.00 34.21  ? 681  LEU A CA  1 
ATOM   2986 C  C   . LEU A 1 418 ? 2.732   -25.817 -24.794 1.00 34.97  ? 681  LEU A C   1 
ATOM   2987 O  O   . LEU A 1 418 ? 1.781   -25.612 -24.013 1.00 35.08  ? 681  LEU A O   1 
ATOM   2988 C  CB  . LEU A 1 418 ? 2.786   -27.750 -26.427 1.00 37.53  ? 681  LEU A CB  1 
ATOM   2989 C  CG  . LEU A 1 418 ? 1.894   -28.730 -25.676 1.00 40.16  ? 681  LEU A CG  1 
ATOM   2990 C  CD1 . LEU A 1 418 ? 0.523   -28.829 -26.343 1.00 38.83  ? 681  LEU A CD1 1 
ATOM   2991 C  CD2 . LEU A 1 418 ? 2.550   -30.098 -25.607 1.00 39.23  ? 681  LEU A CD2 1 
ATOM   2992 N  N   . ASN A 1 419 ? 4.021   -25.675 -24.436 1.00 37.02  ? 682  ASN A N   1 
ATOM   2993 C  CA  . ASN A 1 419 ? 4.428   -25.282 -23.065 1.00 37.87  ? 682  ASN A CA  1 
ATOM   2994 C  C   . ASN A 1 419 ? 3.998   -23.827 -22.816 1.00 34.09  ? 682  ASN A C   1 
ATOM   2995 O  O   . ASN A 1 419 ? 3.500   -23.558 -21.723 1.00 39.37  ? 682  ASN A O   1 
ATOM   2996 C  CB  . ASN A 1 419 ? 5.931   -25.516 -22.842 1.00 43.18  ? 682  ASN A CB  1 
ATOM   2997 C  CG  . ASN A 1 419 ? 6.295   -26.963 -22.541 1.00 42.71  ? 682  ASN A CG  1 
ATOM   2998 O  OD1 . ASN A 1 419 ? 5.511   -27.722 -21.970 1.00 40.84  ? 682  ASN A OD1 1 
ATOM   2999 N  ND2 . ASN A 1 419 ? 7.505   -27.357 -22.900 1.00 42.23  ? 682  ASN A ND2 1 
ATOM   3000 N  N   . ASP A 1 420 ? 4.117   -22.945 -23.807 1.00 35.57  ? 683  ASP A N   1 
ATOM   3001 C  CA  . ASP A 1 420 ? 3.807   -21.497 -23.631 1.00 41.19  ? 683  ASP A CA  1 
ATOM   3002 C  C   . ASP A 1 420 ? 2.280   -21.269 -23.528 1.00 46.33  ? 683  ASP A C   1 
ATOM   3003 O  O   . ASP A 1 420 ? 1.885   -20.354 -22.818 1.00 40.25  ? 683  ASP A O   1 
ATOM   3004 C  CB  . ASP A 1 420 ? 4.377   -20.642 -24.760 1.00 38.98  ? 683  ASP A CB  1 
ATOM   3005 C  CG  . ASP A 1 420 ? 4.302   -19.142 -24.453 1.00 44.87  ? 683  ASP A CG  1 
ATOM   3006 O  OD1 . ASP A 1 420 ? 4.634   -18.788 -23.309 1.00 42.63  ? 683  ASP A OD1 1 
ATOM   3007 O  OD2 . ASP A 1 420 ? 3.851   -18.357 -25.345 1.00 42.51  ? 683  ASP A OD2 1 
ATOM   3008 N  N   . MET A 1 421 ? 1.441   -22.099 -24.166 1.00 41.73  ? 684  MET A N   1 
ATOM   3009 C  CA  . MET A 1 421 ? -0.036  -22.049 -23.972 1.00 39.45  ? 684  MET A CA  1 
ATOM   3010 C  C   . MET A 1 421 ? -0.399  -22.551 -22.572 1.00 40.08  ? 684  MET A C   1 
ATOM   3011 O  O   . MET A 1 421 ? -1.574  -22.434 -22.204 1.00 41.71  ? 684  MET A O   1 
ATOM   3012 C  CB  . MET A 1 421 ? -0.754  -22.877 -25.044 1.00 40.22  ? 684  MET A CB  1 
ATOM   3013 C  CG  . MET A 1 421 ? -0.590  -22.290 -26.419 1.00 36.68  ? 684  MET A CG  1 
ATOM   3014 S  SD  . MET A 1 421 ? -1.494  -23.202 -27.738 1.00 44.31  ? 684  MET A SD  1 
ATOM   3015 C  CE  . MET A 1 421 ? -0.660  -24.784 -27.722 1.00 46.38  ? 684  MET A CE  1 
ATOM   3016 N  N   . GLY A 1 422 ? 0.559   -23.121 -21.830 1.00 38.02  ? 685  GLY A N   1 
ATOM   3017 C  CA  . GLY A 1 422 ? 0.371   -23.697 -20.484 1.00 32.37  ? 685  GLY A CA  1 
ATOM   3018 C  C   . GLY A 1 422 ? -0.097  -25.151 -20.475 1.00 34.34  ? 685  GLY A C   1 
ATOM   3019 O  O   . GLY A 1 422 ? -0.357  -25.686 -19.382 1.00 35.26  ? 685  GLY A O   1 
ATOM   3020 N  N   . LYS A 1 423 ? -0.187  -25.809 -21.617 1.00 31.38  ? 686  LYS A N   1 
ATOM   3021 C  CA  . LYS A 1 423 ? -0.614  -27.243 -21.699 1.00 36.69  ? 686  LYS A CA  1 
ATOM   3022 C  C   . LYS A 1 423 ? 0.588   -28.192 -21.538 1.00 35.65  ? 686  LYS A C   1 
ATOM   3023 O  O   . LYS A 1 423 ? 0.901   -29.004 -22.465 1.00 35.82  ? 686  LYS A O   1 
ATOM   3024 C  CB  . LYS A 1 423 ? -1.397  -27.444 -22.999 1.00 33.93  ? 686  LYS A CB  1 
ATOM   3025 C  CG  . LYS A 1 423 ? -2.527  -26.438 -23.196 1.00 34.75  ? 686  LYS A CG  1 
ATOM   3026 C  CD  . LYS A 1 423 ? -3.449  -26.378 -21.992 1.00 38.30  ? 686  LYS A CD  1 
ATOM   3027 C  CE  . LYS A 1 423 ? -4.623  -25.439 -22.173 1.00 42.23  ? 686  LYS A CE  1 
ATOM   3028 N  NZ  . LYS A 1 423 ? -4.184  -24.023 -22.132 1.00 42.82  ? 686  LYS A NZ  1 
ATOM   3029 N  N   . VAL A 1 424 ? 1.169   -28.153 -20.346 1.00 40.67  ? 687  VAL A N   1 
ATOM   3030 C  CA  . VAL A 1 424 ? 2.366   -28.940 -19.932 1.00 40.10  ? 687  VAL A CA  1 
ATOM   3031 C  C   . VAL A 1 424 ? 1.985   -30.411 -19.840 1.00 33.38  ? 687  VAL A C   1 
ATOM   3032 O  O   . VAL A 1 424 ? 0.960   -30.751 -19.179 1.00 37.30  ? 687  VAL A O   1 
ATOM   3033 C  CB  . VAL A 1 424 ? 2.923   -28.410 -18.593 1.00 47.54  ? 687  VAL A CB  1 
ATOM   3034 C  CG1 . VAL A 1 424 ? 3.941   -29.355 -17.972 1.00 54.79  ? 687  VAL A CG1 1 
ATOM   3035 C  CG2 . VAL A 1 424 ? 3.518   -27.023 -18.769 1.00 50.05  ? 687  VAL A CG2 1 
ATOM   3036 N  N   . ARG A 1 425 ? 2.794   -31.261 -20.473 1.00 31.55  ? 688  ARG A N   1 
ATOM   3037 C  CA  . ARG A 1 425 ? 2.589   -32.724 -20.529 1.00 33.58  ? 688  ARG A CA  1 
ATOM   3038 C  C   . ARG A 1 425 ? 2.816   -33.315 -19.147 1.00 36.64  ? 688  ARG A C   1 
ATOM   3039 O  O   . ARG A 1 425 ? 3.724   -32.812 -18.453 1.00 44.80  ? 688  ARG A O   1 
ATOM   3040 C  CB  . ARG A 1 425 ? 3.502   -33.359 -21.572 1.00 33.27  ? 688  ARG A CB  1 
ATOM   3041 C  CG  . ARG A 1 425 ? 3.200   -32.901 -22.985 1.00 33.65  ? 688  ARG A CG  1 
ATOM   3042 C  CD  . ARG A 1 425 ? 4.315   -33.235 -23.930 1.00 34.92  ? 688  ARG A CD  1 
ATOM   3043 N  NE  . ARG A 1 425 ? 5.554   -32.641 -23.446 1.00 35.38  ? 688  ARG A NE  1 
ATOM   3044 C  CZ  . ARG A 1 425 ? 6.791   -33.093 -23.686 1.00 37.69  ? 688  ARG A CZ  1 
ATOM   3045 N  NH1 . ARG A 1 425 ? 7.006   -34.150 -24.460 1.00 32.55  ? 688  ARG A NH1 1 
ATOM   3046 N  NH2 . ARG A 1 425 ? 7.820   -32.435 -23.157 1.00 39.59  ? 688  ARG A NH2 1 
ATOM   3047 N  N   . LYS A 1 426 ? 2.014   -34.322 -18.807 1.00 35.05  ? 689  LYS A N   1 
ATOM   3048 C  CA  . LYS A 1 426 ? 2.050   -35.143 -17.577 1.00 40.43  ? 689  LYS A CA  1 
ATOM   3049 C  C   . LYS A 1 426 ? 3.225   -36.143 -17.675 1.00 44.01  ? 689  LYS A C   1 
ATOM   3050 O  O   . LYS A 1 426 ? 3.397   -36.752 -18.736 1.00 44.33  ? 689  LYS A O   1 
ATOM   3051 C  CB  . LYS A 1 426 ? 0.721   -35.894 -17.435 1.00 45.11  ? 689  LYS A CB  1 
ATOM   3052 C  CG  . LYS A 1 426 ? 0.413   -36.410 -16.039 1.00 52.36  ? 689  LYS A CG  1 
ATOM   3053 C  CD  . LYS A 1 426 ? -0.927  -37.068 -15.908 1.00 56.71  ? 689  LYS A CD  1 
ATOM   3054 C  CE  . LYS A 1 426 ? -0.944  -38.439 -16.546 1.00 71.97  ? 689  LYS A CE  1 
ATOM   3055 N  NZ  . LYS A 1 426 ? -2.305  -38.834 -16.975 1.00 80.82  ? 689  LYS A NZ  1 
ATOM   3056 N  N   . ASP A 1 427 ? 4.003   -36.329 -16.606 1.00 50.81  ? 690  ASP A N   1 
ATOM   3057 C  CA  . ASP A 1 427 ? 4.893   -37.520 -16.437 1.00 47.71  ? 690  ASP A CA  1 
ATOM   3058 C  C   . ASP A 1 427 ? 5.993   -37.571 -17.514 1.00 49.17  ? 690  ASP A C   1 
ATOM   3059 O  O   . ASP A 1 427 ? 6.302   -38.687 -18.001 1.00 50.18  ? 690  ASP A O   1 
ATOM   3060 C  CB  . ASP A 1 427 ? 4.087   -38.817 -16.498 1.00 51.35  ? 690  ASP A CB  1 
ATOM   3061 C  CG  . ASP A 1 427 ? 3.165   -39.029 -15.311 1.00 62.12  ? 690  ASP A CG  1 
ATOM   3062 O  OD1 . ASP A 1 427 ? 3.365   -38.332 -14.279 1.00 65.51  ? 690  ASP A OD1 1 
ATOM   3063 O  OD2 . ASP A 1 427 ? 2.252   -39.892 -15.430 1.00 63.97  ? 690  ASP A OD2 1 
ATOM   3064 N  N   . ILE A 1 428 ? 6.536   -36.396 -17.860 1.00 46.53  ? 691  ILE A N   1 
ATOM   3065 C  CA  . ILE A 1 428 ? 7.687   -36.273 -18.800 1.00 46.77  ? 691  ILE A CA  1 
ATOM   3066 C  C   . ILE A 1 428 ? 8.309   -34.908 -18.504 1.00 47.44  ? 691  ILE A C   1 
ATOM   3067 O  O   . ILE A 1 428 ? 7.571   -34.020 -18.071 1.00 46.92  ? 691  ILE A O   1 
ATOM   3068 C  CB  . ILE A 1 428 ? 7.292   -36.403 -20.285 1.00 47.93  ? 691  ILE A CB  1 
ATOM   3069 C  CG1 . ILE A 1 428 ? 8.529   -36.503 -21.180 1.00 44.33  ? 691  ILE A CG1 1 
ATOM   3070 C  CG2 . ILE A 1 428 ? 6.379   -35.267 -20.713 1.00 44.24  ? 691  ILE A CG2 1 
ATOM   3071 C  CD1 . ILE A 1 428 ? 8.260   -37.085 -22.542 1.00 43.20  ? 691  ILE A CD1 1 
ATOM   3072 N  N   . GLN A 1 429 ? 9.619   -34.765 -18.700 1.00 50.88  ? 692  GLN A N   1 
ATOM   3073 C  CA  . GLN A 1 429 ? 10.313  -33.476 -18.436 1.00 49.32  ? 692  GLN A CA  1 
ATOM   3074 C  C   . GLN A 1 429 ? 9.870   -32.435 -19.467 1.00 46.87  ? 692  GLN A C   1 
ATOM   3075 O  O   . GLN A 1 429 ? 9.744   -32.785 -20.642 1.00 41.93  ? 692  GLN A O   1 
ATOM   3076 C  CB  . GLN A 1 429 ? 11.831  -33.668 -18.377 1.00 63.08  ? 692  GLN A CB  1 
ATOM   3077 C  CG  . GLN A 1 429 ? 12.289  -34.646 -17.307 1.00 70.59  ? 692  GLN A CG  1 
ATOM   3078 C  CD  . GLN A 1 429 ? 13.738  -35.030 -17.485 1.00 88.39  ? 692  GLN A CD  1 
ATOM   3079 O  OE1 . GLN A 1 429 ? 14.134  -35.576 -18.513 1.00 93.65  ? 692  GLN A OE1 1 
ATOM   3080 N  NE2 . GLN A 1 429 ? 14.545  -34.750 -16.475 1.00 95.15  ? 692  GLN A NE2 1 
ATOM   3081 N  N   . GLN A 1 430 ? 9.718   -31.187 -19.040 1.00 51.09  ? 693  GLN A N   1 
ATOM   3082 C  CA  . GLN A 1 430 ? 9.149   -30.128 -19.915 1.00 53.79  ? 693  GLN A CA  1 
ATOM   3083 C  C   . GLN A 1 430 ? 9.743   -30.117 -21.323 1.00 50.76  ? 693  GLN A C   1 
ATOM   3084 O  O   . GLN A 1 430 ? 8.978   -29.860 -22.255 1.00 46.84  ? 693  GLN A O   1 
ATOM   3085 C  CB  . GLN A 1 430 ? 9.316   -28.757 -19.254 1.00 60.29  ? 693  GLN A CB  1 
ATOM   3086 C  CG  . GLN A 1 430 ? 8.206   -27.783 -19.613 1.00 70.01  ? 693  GLN A CG  1 
ATOM   3087 C  CD  . GLN A 1 430 ? 8.412   -26.422 -18.999 1.00 72.87  ? 693  GLN A CD  1 
ATOM   3088 O  OE1 . GLN A 1 430 ? 9.509   -26.073 -18.570 1.00 70.23  ? 693  GLN A OE1 1 
ATOM   3089 N  NE2 . GLN A 1 430 ? 7.351   -25.635 -18.963 1.00 71.35  ? 693  GLN A NE2 1 
ATOM   3090 N  N   . TRP A 1 431 ? 11.043  -30.355 -21.478 1.00 45.83  ? 694  TRP A N   1 
ATOM   3091 C  CA  . TRP A 1 431 ? 11.651  -30.206 -22.825 1.00 41.40  ? 694  TRP A CA  1 
ATOM   3092 C  C   . TRP A 1 431 ? 12.120  -31.545 -23.409 1.00 37.28  ? 694  TRP A C   1 
ATOM   3093 O  O   . TRP A 1 431 ? 12.784  -31.519 -24.446 1.00 41.98  ? 694  TRP A O   1 
ATOM   3094 C  CB  . TRP A 1 431 ? 12.755  -29.151 -22.767 1.00 47.59  ? 694  TRP A CB  1 
ATOM   3095 C  CG  . TRP A 1 431 ? 12.229  -27.810 -22.362 1.00 55.80  ? 694  TRP A CG  1 
ATOM   3096 C  CD1 . TRP A 1 431 ? 12.433  -27.165 -21.178 1.00 54.66  ? 694  TRP A CD1 1 
ATOM   3097 C  CD2 . TRP A 1 431 ? 11.365  -26.961 -23.137 1.00 52.51  ? 694  TRP A CD2 1 
ATOM   3098 N  NE1 . TRP A 1 431 ? 11.774  -25.967 -21.171 1.00 60.89  ? 694  TRP A NE1 1 
ATOM   3099 C  CE2 . TRP A 1 431 ? 11.109  -25.814 -22.359 1.00 57.26  ? 694  TRP A CE2 1 
ATOM   3100 C  CE3 . TRP A 1 431 ? 10.795  -27.052 -24.410 1.00 47.38  ? 694  TRP A CE3 1 
ATOM   3101 C  CZ2 . TRP A 1 431 ? 10.305  -24.773 -22.814 1.00 57.05  ? 694  TRP A CZ2 1 
ATOM   3102 C  CZ3 . TRP A 1 431 ? 10.003  -26.021 -24.860 1.00 54.50  ? 694  TRP A CZ3 1 
ATOM   3103 C  CH2 . TRP A 1 431 ? 9.762   -24.898 -24.071 1.00 51.96  ? 694  TRP A CH2 1 
ATOM   3104 N  N   . GLU A 1 432 ? 11.755  -32.659 -22.783 1.00 39.07  ? 695  GLU A N   1 
ATOM   3105 C  CA  . GLU A 1 432 ? 12.093  -33.994 -23.333 1.00 43.13  ? 695  GLU A CA  1 
ATOM   3106 C  C   . GLU A 1 432 ? 11.091  -34.319 -24.449 1.00 42.84  ? 695  GLU A C   1 
ATOM   3107 O  O   . GLU A 1 432 ? 9.900   -34.078 -24.260 1.00 38.47  ? 695  GLU A O   1 
ATOM   3108 C  CB  . GLU A 1 432 ? 12.083  -35.031 -22.210 1.00 47.39  ? 695  GLU A CB  1 
ATOM   3109 C  CG  . GLU A 1 432 ? 12.545  -36.412 -22.634 1.00 64.73  ? 695  GLU A CG  1 
ATOM   3110 C  CD  . GLU A 1 432 ? 14.022  -36.530 -22.974 1.00 74.76  ? 695  GLU A CD  1 
ATOM   3111 O  OE1 . GLU A 1 432 ? 14.398  -37.530 -23.614 1.00 70.24  ? 695  GLU A OE1 1 
ATOM   3112 O  OE2 . GLU A 1 432 ? 14.792  -35.624 -22.599 1.00 81.92  ? 695  GLU A OE2 1 
ATOM   3113 N  N   . PRO A 1 433 ? 11.539  -34.837 -25.604 1.00 39.01  ? 696  PRO A N   1 
ATOM   3114 C  CA  . PRO A 1 433 ? 10.632  -35.112 -26.719 1.00 36.17  ? 696  PRO A CA  1 
ATOM   3115 C  C   . PRO A 1 433 ? 9.606   -36.182 -26.355 1.00 33.41  ? 696  PRO A C   1 
ATOM   3116 O  O   . PRO A 1 433 ? 9.897   -37.103 -25.622 1.00 30.97  ? 696  PRO A O   1 
ATOM   3117 C  CB  . PRO A 1 433 ? 11.536  -35.633 -27.835 1.00 42.28  ? 696  PRO A CB  1 
ATOM   3118 C  CG  . PRO A 1 433 ? 12.953  -35.143 -27.401 1.00 45.45  ? 696  PRO A CG  1 
ATOM   3119 C  CD  . PRO A 1 433 ? 12.934  -35.227 -25.894 1.00 36.90  ? 696  PRO A CD  1 
ATOM   3120 N  N   . SER A 1 434 ? 8.382   -36.041 -26.864 1.00 30.58  ? 697  SER A N   1 
ATOM   3121 C  CA  . SER A 1 434 ? 7.301   -37.001 -26.588 1.00 31.33  ? 697  SER A CA  1 
ATOM   3122 C  C   . SER A 1 434 ? 7.698   -38.398 -27.060 1.00 28.91  ? 697  SER A C   1 
ATOM   3123 O  O   . SER A 1 434 ? 8.331   -38.521 -28.056 1.00 32.31  ? 697  SER A O   1 
ATOM   3124 C  CB  . SER A 1 434 ? 6.020   -36.539 -27.283 1.00 27.22  ? 697  SER A CB  1 
ATOM   3125 O  OG  . SER A 1 434 ? 5.521   -35.361 -26.686 1.00 27.69  ? 697  SER A OG  1 
ATOM   3126 N  N   . ARG A 1 435 ? 7.297   -39.417 -26.293 0.50 30.30  ? 698  ARG A N   1 
ATOM   3127 C  CA  . ARG A 1 435 ? 7.301   -40.848 -26.702 0.50 33.30  ? 698  ARG A CA  1 
ATOM   3128 C  C   . ARG A 1 435 ? 6.060   -41.100 -27.572 0.50 33.30  ? 698  ARG A C   1 
ATOM   3129 O  O   . ARG A 1 435 ? 4.957   -40.905 -27.062 0.50 35.48  ? 698  ARG A O   1 
ATOM   3130 C  CB  . ARG A 1 435 ? 7.283   -41.755 -25.461 0.50 32.84  ? 698  ARG A CB  1 
ATOM   3131 C  CG  . ARG A 1 435 ? 8.433   -41.496 -24.493 0.50 35.31  ? 698  ARG A CG  1 
ATOM   3132 C  CD  . ARG A 1 435 ? 8.541   -42.514 -23.372 0.50 37.29  ? 698  ARG A CD  1 
ATOM   3133 N  NE  . ARG A 1 435 ? 7.592   -42.241 -22.305 0.50 41.40  ? 698  ARG A NE  1 
ATOM   3134 C  CZ  . ARG A 1 435 ? 7.898   -41.675 -21.141 0.50 41.87  ? 698  ARG A CZ  1 
ATOM   3135 N  NH1 . ARG A 1 435 ? 9.145   -41.326 -20.876 0.50 45.00  ? 698  ARG A NH1 1 
ATOM   3136 N  NH2 . ARG A 1 435 ? 6.955   -41.475 -20.240 0.50 42.08  ? 698  ARG A NH2 1 
ATOM   3137 N  N   . GLY A 1 436 ? 6.237   -41.489 -28.834 1.00 32.60  ? 699  GLY A N   1 
ATOM   3138 C  CA  . GLY A 1 436 ? 5.131   -41.903 -29.703 1.00 35.33  ? 699  GLY A CA  1 
ATOM   3139 C  C   . GLY A 1 436 ? 4.852   -43.408 -29.641 1.00 32.72  ? 699  GLY A C   1 
ATOM   3140 O  O   . GLY A 1 436 ? 5.639   -44.162 -29.082 1.00 34.24  ? 699  GLY A O   1 
ATOM   3141 N  N   . TRP A 1 437 ? 3.740   -43.818 -30.224 1.00 27.30  ? 700  TRP A N   1 
ATOM   3142 C  CA  . TRP A 1 437 ? 3.316   -45.222 -30.291 1.00 26.64  ? 700  TRP A CA  1 
ATOM   3143 C  C   . TRP A 1 437 ? 3.431   -45.643 -31.742 1.00 29.53  ? 700  TRP A C   1 
ATOM   3144 O  O   . TRP A 1 437 ? 2.976   -44.895 -32.623 1.00 29.78  ? 700  TRP A O   1 
ATOM   3145 C  CB  . TRP A 1 437 ? 1.892   -45.351 -29.746 1.00 25.80  ? 700  TRP A CB  1 
ATOM   3146 C  CG  . TRP A 1 437 ? 1.755   -44.912 -28.332 1.00 25.38  ? 700  TRP A CG  1 
ATOM   3147 C  CD1 . TRP A 1 437 ? 1.470   -43.669 -27.871 1.00 29.05  ? 700  TRP A CD1 1 
ATOM   3148 C  CD2 . TRP A 1 437 ? 1.915   -45.743 -27.171 1.00 26.54  ? 700  TRP A CD2 1 
ATOM   3149 N  NE1 . TRP A 1 437 ? 1.475   -43.660 -26.509 1.00 29.20  ? 700  TRP A NE1 1 
ATOM   3150 C  CE2 . TRP A 1 437 ? 1.706   -44.928 -26.053 1.00 24.95  ? 700  TRP A CE2 1 
ATOM   3151 C  CE3 . TRP A 1 437 ? 2.217   -47.083 -26.993 1.00 25.77  ? 700  TRP A CE3 1 
ATOM   3152 C  CZ2 . TRP A 1 437 ? 1.758   -45.407 -24.747 1.00 28.92  ? 700  TRP A CZ2 1 
ATOM   3153 C  CZ3 . TRP A 1 437 ? 2.248   -47.570 -25.711 1.00 29.84  ? 700  TRP A CZ3 1 
ATOM   3154 C  CH2 . TRP A 1 437 ? 2.019   -46.745 -24.603 1.00 28.35  ? 700  TRP A CH2 1 
ATOM   3155 N  N   . ASN A 1 438 ? 4.014   -46.799 -31.996 1.00 27.97  ? 701  ASN A N   1 
ATOM   3156 C  CA  . ASN A 1 438 ? 4.152   -47.300 -33.377 1.00 29.98  ? 701  ASN A CA  1 
ATOM   3157 C  C   . ASN A 1 438 ? 2.973   -48.137 -33.839 1.00 32.69  ? 701  ASN A C   1 
ATOM   3158 O  O   . ASN A 1 438 ? 2.962   -48.448 -35.008 1.00 35.20  ? 701  ASN A O   1 
ATOM   3159 C  CB  . ASN A 1 438 ? 5.407   -48.183 -33.488 1.00 37.81  ? 701  ASN A CB  1 
ATOM   3160 C  CG  . ASN A 1 438 ? 6.655   -47.370 -33.193 1.00 49.14  ? 701  ASN A CG  1 
ATOM   3161 O  OD1 . ASN A 1 438 ? 7.482   -47.750 -32.354 1.00 53.78  ? 701  ASN A OD1 1 
ATOM   3162 N  ND2 . ASN A 1 438 ? 6.747   -46.218 -33.841 1.00 39.50  ? 701  ASN A ND2 1 
ATOM   3163 N  N   . ASP A 1 439 ? 2.048   -48.541 -32.972 1.00 31.59  ? 702  ASP A N   1 
ATOM   3164 C  CA  . ASP A 1 439 ? 0.967   -49.490 -33.356 1.00 33.56  ? 702  ASP A CA  1 
ATOM   3165 C  C   . ASP A 1 439 ? -0.316  -48.933 -32.740 1.00 29.46  ? 702  ASP A C   1 
ATOM   3166 O  O   . ASP A 1 439 ? -0.301  -48.709 -31.520 1.00 29.40  ? 702  ASP A O   1 
ATOM   3167 C  CB  . ASP A 1 439 ? 1.409   -50.882 -32.902 1.00 39.11  ? 702  ASP A CB  1 
ATOM   3168 C  CG  . ASP A 1 439 ? 0.396   -52.012 -32.914 1.00 48.23  ? 702  ASP A CG  1 
ATOM   3169 O  OD1 . ASP A 1 439 ? -0.769  -51.803 -33.412 1.00 47.29  ? 702  ASP A OD1 1 
ATOM   3170 O  OD2 . ASP A 1 439 ? 0.785   -53.120 -32.378 1.00 55.37  ? 702  ASP A OD2 1 
ATOM   3171 N  N   . TRP A 1 440 ? -1.336  -48.681 -33.555 1.00 27.70  ? 703  TRP A N   1 
ATOM   3172 C  CA  . TRP A 1 440 ? -2.613  -48.088 -33.098 1.00 27.62  ? 703  TRP A CA  1 
ATOM   3173 C  C   . TRP A 1 440 ? -3.238  -48.957 -31.989 1.00 26.22  ? 703  TRP A C   1 
ATOM   3174 O  O   . TRP A 1 440 ? -4.007  -48.428 -31.134 1.00 26.47  ? 703  TRP A O   1 
ATOM   3175 C  CB  . TRP A 1 440 ? -3.556  -47.845 -34.277 1.00 26.80  ? 703  TRP A CB  1 
ATOM   3176 C  CG  . TRP A 1 440 ? -4.071  -49.085 -34.945 1.00 29.91  ? 703  TRP A CG  1 
ATOM   3177 C  CD1 . TRP A 1 440 ? -3.537  -49.727 -36.023 1.00 33.12  ? 703  TRP A CD1 1 
ATOM   3178 C  CD2 . TRP A 1 440 ? -5.190  -49.881 -34.550 1.00 26.62  ? 703  TRP A CD2 1 
ATOM   3179 N  NE1 . TRP A 1 440 ? -4.284  -50.820 -36.368 1.00 28.78  ? 703  TRP A NE1 1 
ATOM   3180 C  CE2 . TRP A 1 440 ? -5.287  -50.961 -35.461 1.00 28.24  ? 703  TRP A CE2 1 
ATOM   3181 C  CE3 . TRP A 1 440 ? -6.156  -49.762 -33.553 1.00 27.18  ? 703  TRP A CE3 1 
ATOM   3182 C  CZ2 . TRP A 1 440 ? -6.277  -51.941 -35.383 1.00 29.54  ? 703  TRP A CZ2 1 
ATOM   3183 C  CZ3 . TRP A 1 440 ? -7.143  -50.719 -33.493 1.00 27.06  ? 703  TRP A CZ3 1 
ATOM   3184 C  CH2 . TRP A 1 440 ? -7.209  -51.787 -34.392 1.00 30.82  ? 703  TRP A CH2 1 
ATOM   3185 N  N   . THR A 1 441 ? -2.914  -50.231 -31.953 1.00 26.23  ? 704  THR A N   1 
ATOM   3186 C  CA  . THR A 1 441 ? -3.464  -51.169 -30.929 1.00 26.65  ? 704  THR A CA  1 
ATOM   3187 C  C   . THR A 1 441 ? -2.838  -50.976 -29.550 1.00 25.70  ? 704  THR A C   1 
ATOM   3188 O  O   . THR A 1 441 ? -3.354  -51.554 -28.578 1.00 28.70  ? 704  THR A O   1 
ATOM   3189 C  CB  . THR A 1 441 ? -3.399  -52.647 -31.355 1.00 25.92  ? 704  THR A CB  1 
ATOM   3190 O  OG1 . THR A 1 441 ? -2.053  -53.090 -31.422 1.00 26.81  ? 704  THR A OG1 1 
ATOM   3191 C  CG2 . THR A 1 441 ? -4.091  -52.907 -32.674 1.00 26.15  ? 704  THR A CG2 1 
ATOM   3192 N  N   . GLN A 1 442 ? -1.784  -50.167 -29.435 0.34 24.81  ? 705  GLN A N   1 
ATOM   3193 C  CA  . GLN A 1 442 ? -1.108  -49.927 -28.137 0.34 23.89  ? 705  GLN A CA  1 
ATOM   3194 C  C   . GLN A 1 442 ? -1.301  -48.471 -27.684 0.34 22.97  ? 705  GLN A C   1 
ATOM   3195 O  O   . GLN A 1 442 ? -0.796  -48.131 -26.598 0.34 23.33  ? 705  GLN A O   1 
ATOM   3196 C  CB  . GLN A 1 442 ? 0.349   -50.373 -28.281 0.34 24.25  ? 705  GLN A CB  1 
ATOM   3197 C  CG  . GLN A 1 442 ? 0.489   -51.654 -29.104 0.34 24.20  ? 705  GLN A CG  1 
ATOM   3198 C  CD  . GLN A 1 442 ? 0.259   -52.902 -28.287 0.34 24.75  ? 705  GLN A CD  1 
ATOM   3199 O  OE1 . GLN A 1 442 ? 0.610   -52.946 -27.114 0.34 23.80  ? 705  GLN A OE1 1 
ATOM   3200 N  NE2 . GLN A 1 442 ? -0.336  -53.927 -28.896 0.34 24.66  ? 705  GLN A NE2 1 
ATOM   3201 N  N   . VAL A 1 443 ? -2.013  -47.649 -28.461 1.00 22.75  ? 706  VAL A N   1 
ATOM   3202 C  CA  . VAL A 1 443 ? -2.280  -46.221 -28.109 1.00 25.59  ? 706  VAL A CA  1 
ATOM   3203 C  C   . VAL A 1 443 ? -3.323  -46.171 -27.012 1.00 21.93  ? 706  VAL A C   1 
ATOM   3204 O  O   . VAL A 1 443 ? -4.363  -46.783 -27.143 1.00 24.72  ? 706  VAL A O   1 
ATOM   3205 C  CB  . VAL A 1 443 ? -2.755  -45.420 -29.351 1.00 30.58  ? 706  VAL A CB  1 
ATOM   3206 C  CG1 . VAL A 1 443 ? -3.243  -44.032 -29.016 1.00 35.20  ? 706  VAL A CG1 1 
ATOM   3207 C  CG2 . VAL A 1 443 ? -1.633  -45.298 -30.335 1.00 36.33  ? 706  VAL A CG2 1 
ATOM   3208 N  N   . PRO A 1 444 ? -3.107  -45.414 -25.923 1.00 21.55  ? 707  PRO A N   1 
ATOM   3209 C  CA  . PRO A 1 444 ? -4.168  -45.177 -24.945 1.00 21.28  ? 707  PRO A CA  1 
ATOM   3210 C  C   . PRO A 1 444 ? -5.154  -44.086 -25.404 1.00 24.36  ? 707  PRO A C   1 
ATOM   3211 O  O   . PRO A 1 444 ? -4.713  -43.084 -25.928 1.00 22.43  ? 707  PRO A O   1 
ATOM   3212 C  CB  . PRO A 1 444 ? -3.391  -44.689 -23.731 1.00 23.79  ? 707  PRO A CB  1 
ATOM   3213 C  CG  . PRO A 1 444 ? -2.137  -44.031 -24.296 1.00 22.91  ? 707  PRO A CG  1 
ATOM   3214 C  CD  . PRO A 1 444 ? -1.867  -44.703 -25.613 1.00 22.71  ? 707  PRO A CD  1 
ATOM   3215 N  N   . PHE A 1 445 ? -6.457  -44.247 -25.181 1.00 21.14  ? 708  PHE A N   1 
ATOM   3216 C  CA  . PHE A 1 445 ? -7.459  -43.199 -25.519 1.00 21.15  ? 708  PHE A CA  1 
ATOM   3217 C  C   . PHE A 1 445 ? -8.728  -43.466 -24.729 1.00 22.07  ? 708  PHE A C   1 
ATOM   3218 O  O   . PHE A 1 445 ? -9.189  -44.607 -24.746 1.00 20.69  ? 708  PHE A O   1 
ATOM   3219 C  CB  . PHE A 1 445 ? -7.772  -43.208 -27.005 1.00 21.69  ? 708  PHE A CB  1 
ATOM   3220 C  CG  . PHE A 1 445 ? -8.631  -42.056 -27.505 1.00 22.91  ? 708  PHE A CG  1 
ATOM   3221 C  CD1 . PHE A 1 445 ? -8.354  -40.739 -27.171 1.00 23.92  ? 708  PHE A CD1 1 
ATOM   3222 C  CD2 . PHE A 1 445 ? -9.741  -42.319 -28.286 1.00 24.82  ? 708  PHE A CD2 1 
ATOM   3223 C  CE1 . PHE A 1 445 ? -9.135  -39.693 -27.650 1.00 25.73  ? 708  PHE A CE1 1 
ATOM   3224 C  CE2 . PHE A 1 445 ? -10.497 -41.273 -28.810 1.00 26.21  ? 708  PHE A CE2 1 
ATOM   3225 C  CZ  . PHE A 1 445 ? -10.226 -39.973 -28.437 1.00 27.17  ? 708  PHE A CZ  1 
ATOM   3226 N  N   . CYS A 1 446 ? -9.206  -42.455 -24.024 1.00 22.56  ? 709  CYS A N   1 
ATOM   3227 C  CA  . CYS A 1 446 ? -10.468 -42.537 -23.221 1.00 24.45  ? 709  CYS A CA  1 
ATOM   3228 C  C   . CYS A 1 446 ? -10.400 -43.743 -22.270 1.00 23.19  ? 709  CYS A C   1 
ATOM   3229 O  O   . CYS A 1 446 ? -11.403 -44.495 -22.206 1.00 23.06  ? 709  CYS A O   1 
ATOM   3230 C  CB  . CYS A 1 446 ? -11.646 -42.644 -24.167 1.00 26.11  ? 709  CYS A CB  1 
ATOM   3231 S  SG  . CYS A 1 446 ? -11.877 -41.116 -25.127 1.00 28.88  ? 709  CYS A SG  1 
ATOM   3232 N  N   . SER A 1 447 ? -9.258  -43.930 -21.608 1.00 23.61  ? 710  SER A N   1 
ATOM   3233 C  CA  . SER A 1 447 ? -8.978  -44.954 -20.575 1.00 28.16  ? 710  SER A CA  1 
ATOM   3234 C  C   . SER A 1 447 ? -8.940  -46.372 -21.158 1.00 25.56  ? 710  SER A C   1 
ATOM   3235 O  O   . SER A 1 447 ? -8.886  -47.324 -20.344 1.00 28.21  ? 710  SER A O   1 
ATOM   3236 C  CB  . SER A 1 447 ? -10.024 -44.909 -19.450 1.00 30.54  ? 710  SER A CB  1 
ATOM   3237 O  OG  . SER A 1 447 ? -10.117 -43.613 -18.923 1.00 35.11  ? 710  SER A OG  1 
ATOM   3238 N  N   . HIS A 1 448 ? -8.841  -46.537 -22.471 1.00 21.86  ? 711  HIS A N   1 
ATOM   3239 C  CA  . HIS A 1 448 ? -8.871  -47.855 -23.139 1.00 19.30  ? 711  HIS A CA  1 
ATOM   3240 C  C   . HIS A 1 448 ? -7.651  -48.016 -24.060 1.00 20.05  ? 711  HIS A C   1 
ATOM   3241 O  O   . HIS A 1 448 ? -6.957  -47.020 -24.365 1.00 20.56  ? 711  HIS A O   1 
ATOM   3242 C  CB  . HIS A 1 448 ? -10.155 -48.050 -23.930 1.00 19.48  ? 711  HIS A CB  1 
ATOM   3243 C  CG  . HIS A 1 448 ? -11.376 -48.238 -23.073 1.00 20.88  ? 711  HIS A CG  1 
ATOM   3244 N  ND1 . HIS A 1 448 ? -11.975 -47.199 -22.377 1.00 20.62  ? 711  HIS A ND1 1 
ATOM   3245 C  CD2 . HIS A 1 448 ? -12.051 -49.364 -22.773 1.00 20.54  ? 711  HIS A CD2 1 
ATOM   3246 C  CE1 . HIS A 1 448 ? -12.988 -47.710 -21.652 1.00 23.80  ? 711  HIS A CE1 1 
ATOM   3247 N  NE2 . HIS A 1 448 ? -13.061 -49.034 -21.884 1.00 20.73  ? 711  HIS A NE2 1 
ATOM   3248 N  N   . HIS A 1 449 ? -7.448  -49.247 -24.489 1.00 19.10  ? 712  HIS A N   1 
ATOM   3249 C  CA  . HIS A 1 449 ? -6.722  -49.603 -25.717 1.00 20.41  ? 712  HIS A CA  1 
ATOM   3250 C  C   . HIS A 1 449 ? -7.654  -50.470 -26.539 1.00 21.40  ? 712  HIS A C   1 
ATOM   3251 O  O   . HIS A 1 449 ? -8.749  -50.788 -26.059 1.00 21.44  ? 712  HIS A O   1 
ATOM   3252 C  CB  . HIS A 1 449 ? -5.397  -50.354 -25.432 1.00 20.03  ? 712  HIS A CB  1 
ATOM   3253 C  CG  . HIS A 1 449 ? -5.591  -51.564 -24.580 1.00 19.49  ? 712  HIS A CG  1 
ATOM   3254 N  ND1 . HIS A 1 449 ? -5.780  -51.459 -23.230 1.00 20.34  ? 712  HIS A ND1 1 
ATOM   3255 C  CD2 . HIS A 1 449 ? -5.682  -52.865 -24.880 1.00 19.18  ? 712  HIS A CD2 1 
ATOM   3256 C  CE1 . HIS A 1 449 ? -5.912  -52.663 -22.722 1.00 19.65  ? 712  HIS A CE1 1 
ATOM   3257 N  NE2 . HIS A 1 449 ? -5.885  -53.550 -23.711 1.00 19.65  ? 712  HIS A NE2 1 
ATOM   3258 N  N   . PHE A 1 450 ? -7.246  -50.825 -27.746 1.00 21.72  ? 713  PHE A N   1 
ATOM   3259 C  CA  . PHE A 1 450 ? -8.154  -51.469 -28.722 1.00 21.07  ? 713  PHE A CA  1 
ATOM   3260 C  C   . PHE A 1 450 ? -7.428  -52.642 -29.373 1.00 22.05  ? 713  PHE A C   1 
ATOM   3261 O  O   . PHE A 1 450 ? -6.229  -52.537 -29.765 1.00 23.41  ? 713  PHE A O   1 
ATOM   3262 C  CB  . PHE A 1 450 ? -8.711  -50.418 -29.704 1.00 22.20  ? 713  PHE A CB  1 
ATOM   3263 C  CG  . PHE A 1 450 ? -9.452  -49.292 -29.018 1.00 21.58  ? 713  PHE A CG  1 
ATOM   3264 C  CD1 . PHE A 1 450 ? -8.756  -48.228 -28.474 1.00 25.09  ? 713  PHE A CD1 1 
ATOM   3265 C  CD2 . PHE A 1 450 ? -10.813 -49.357 -28.837 1.00 25.43  ? 713  PHE A CD2 1 
ATOM   3266 C  CE1 . PHE A 1 450 ? -9.437  -47.238 -27.766 1.00 25.53  ? 713  PHE A CE1 1 
ATOM   3267 C  CE2 . PHE A 1 450 ? -11.484 -48.373 -28.126 1.00 26.32  ? 713  PHE A CE2 1 
ATOM   3268 C  CZ  . PHE A 1 450 ? -10.790 -47.302 -27.624 1.00 25.02  ? 713  PHE A CZ  1 
ATOM   3269 N  N   . HIS A 1 451 ? -8.164  -53.742 -29.511 1.00 21.71  ? 714  HIS A N   1 
ATOM   3270 C  CA  . HIS A 1 451 ? -7.676  -55.009 -30.113 1.00 21.71  ? 714  HIS A CA  1 
ATOM   3271 C  C   . HIS A 1 451 ? -8.338  -55.217 -31.465 1.00 24.31  ? 714  HIS A C   1 
ATOM   3272 O  O   . HIS A 1 451 ? -9.516  -54.913 -31.617 1.00 24.15  ? 714  HIS A O   1 
ATOM   3273 C  CB  . HIS A 1 451 ? -7.918  -56.201 -29.167 1.00 20.84  ? 714  HIS A CB  1 
ATOM   3274 C  CG  . HIS A 1 451 ? -7.172  -56.185 -27.859 1.00 22.32  ? 714  HIS A CG  1 
ATOM   3275 N  ND1 . HIS A 1 451 ? -6.025  -56.913 -27.679 1.00 21.98  ? 714  HIS A ND1 1 
ATOM   3276 C  CD2 . HIS A 1 451 ? -7.442  -55.625 -26.648 1.00 22.29  ? 714  HIS A CD2 1 
ATOM   3277 C  CE1 . HIS A 1 451 ? -5.629  -56.820 -26.406 1.00 23.76  ? 714  HIS A CE1 1 
ATOM   3278 N  NE2 . HIS A 1 451 ? -6.458  -56.012 -25.723 1.00 18.17  ? 714  HIS A NE2 1 
ATOM   3279 N  N   . GLU A 1 452 ? -7.606  -55.774 -32.420 1.00 24.95  ? 715  GLU A N   1 
ATOM   3280 C  CA  . GLU A 1 452 ? -8.162  -56.294 -33.692 1.00 26.11  ? 715  GLU A CA  1 
ATOM   3281 C  C   . GLU A 1 452 ? -8.504  -57.775 -33.502 1.00 28.67  ? 715  GLU A C   1 
ATOM   3282 O  O   . GLU A 1 452 ? -7.669  -58.533 -33.076 1.00 30.73  ? 715  GLU A O   1 
ATOM   3283 C  CB  . GLU A 1 452 ? -7.172  -56.049 -34.845 1.00 32.38  ? 715  GLU A CB  1 
ATOM   3284 C  CG  . GLU A 1 452 ? -7.912  -55.693 -36.132 1.00 38.92  ? 715  GLU A CG  1 
ATOM   3285 C  CD  . GLU A 1 452 ? -7.049  -55.248 -37.321 1.00 49.63  ? 715  GLU A CD  1 
ATOM   3286 O  OE1 . GLU A 1 452 ? -7.533  -54.437 -38.175 1.00 40.96  ? 715  GLU A OE1 1 
ATOM   3287 O  OE2 . GLU A 1 452 ? -5.916  -55.747 -37.413 1.00 52.73  ? 715  GLU A OE2 1 
ATOM   3288 N  N   . LEU A 1 453 ? -9.748  -58.174 -33.649 1.00 25.19  ? 716  LEU A N   1 
ATOM   3289 C  CA  . LEU A 1 453 ? -10.167 -59.546 -33.285 1.00 29.81  ? 716  LEU A CA  1 
ATOM   3290 C  C   . LEU A 1 453 ? -10.868 -60.167 -34.491 1.00 34.92  ? 716  LEU A C   1 
ATOM   3291 O  O   . LEU A 1 453 ? -11.781 -59.500 -35.055 1.00 33.23  ? 716  LEU A O   1 
ATOM   3292 C  CB  . LEU A 1 453 ? -11.057 -59.346 -32.052 1.00 32.99  ? 716  LEU A CB  1 
ATOM   3293 C  CG  . LEU A 1 453 ? -11.807 -60.556 -31.528 1.00 39.41  ? 716  LEU A CG  1 
ATOM   3294 C  CD1 . LEU A 1 453 ? -10.841 -61.629 -31.086 1.00 43.12  ? 716  LEU A CD1 1 
ATOM   3295 C  CD2 . LEU A 1 453 ? -12.722 -60.105 -30.380 1.00 37.19  ? 716  LEU A CD2 1 
ATOM   3296 N  N   . ILE A 1 454 ? -10.396 -61.318 -34.966 1.00 33.88  ? 717  ILE A N   1 
ATOM   3297 C  CA  . ILE A 1 454 ? -10.940 -61.873 -36.243 1.00 33.62  ? 717  ILE A CA  1 
ATOM   3298 C  C   . ILE A 1 454 ? -11.930 -62.990 -35.892 1.00 30.31  ? 717  ILE A C   1 
ATOM   3299 O  O   . ILE A 1 454 ? -11.618 -63.856 -35.043 1.00 34.04  ? 717  ILE A O   1 
ATOM   3300 C  CB  . ILE A 1 454 ? -9.802  -62.285 -37.204 1.00 43.00  ? 717  ILE A CB  1 
ATOM   3301 C  CG1 . ILE A 1 454 ? -8.931  -61.079 -37.584 1.00 41.33  ? 717  ILE A CG1 1 
ATOM   3302 C  CG2 . ILE A 1 454 ? -10.337 -62.936 -38.476 1.00 43.76  ? 717  ILE A CG2 1 
ATOM   3303 C  CD1 . ILE A 1 454 ? -7.561  -61.498 -38.018 1.00 47.75  ? 717  ILE A CD1 1 
ATOM   3304 N  N   . MET A 1 455 ? -13.138 -62.857 -36.392 1.00 32.83  ? 718  MET A N   1 
ATOM   3305 C  CA  . MET A 1 455 ? -14.206 -63.856 -36.163 1.00 35.31  ? 718  MET A CA  1 
ATOM   3306 C  C   . MET A 1 455 ? -13.877 -65.122 -36.966 1.00 39.69  ? 718  MET A C   1 
ATOM   3307 O  O   . MET A 1 455 ? -13.182 -65.049 -38.025 1.00 32.93  ? 718  MET A O   1 
ATOM   3308 C  CB  . MET A 1 455 ? -15.561 -63.309 -36.605 1.00 33.52  ? 718  MET A CB  1 
ATOM   3309 C  CG  . MET A 1 455 ? -15.975 -62.103 -35.791 1.00 33.63  ? 718  MET A CG  1 
ATOM   3310 S  SD  . MET A 1 455 ? -17.470 -61.315 -36.355 1.00 36.89  ? 718  MET A SD  1 
ATOM   3311 C  CE  . MET A 1 455 ? -18.652 -62.564 -35.882 1.00 40.27  ? 718  MET A CE  1 
ATOM   3312 N  N   A LYS A 1 456 ? -14.362 -66.263 -36.483 0.34 39.89  ? 719  LYS A N   1 
ATOM   3313 N  N   B LYS A 1 456 ? -14.368 -66.263 -36.482 0.30 40.27  ? 719  LYS A N   1 
ATOM   3314 C  CA  A LYS A 1 456 ? -14.184 -67.584 -37.140 0.34 43.71  ? 719  LYS A CA  1 
ATOM   3315 C  CA  B LYS A 1 456 ? -14.199 -67.589 -37.136 0.30 44.13  ? 719  LYS A CA  1 
ATOM   3316 C  C   A LYS A 1 456 ? -14.590 -67.468 -38.615 0.34 41.50  ? 719  LYS A C   1 
ATOM   3317 C  C   B LYS A 1 456 ? -14.585 -67.463 -38.615 0.30 41.76  ? 719  LYS A C   1 
ATOM   3318 O  O   A LYS A 1 456 ? -13.964 -68.152 -39.441 0.34 44.17  ? 719  LYS A O   1 
ATOM   3319 O  O   B LYS A 1 456 ? -13.946 -68.137 -39.441 0.30 43.98  ? 719  LYS A O   1 
ATOM   3320 C  CB  A LYS A 1 456 ? -14.960 -68.653 -36.364 0.34 44.92  ? 719  LYS A CB  1 
ATOM   3321 C  CB  B LYS A 1 456 ? -15.015 -68.659 -36.400 0.30 45.98  ? 719  LYS A CB  1 
ATOM   3322 C  CG  A LYS A 1 456 ? -14.156 -69.344 -35.269 0.34 47.01  ? 719  LYS A CG  1 
ATOM   3323 C  CG  B LYS A 1 456 ? -14.729 -70.092 -36.835 0.30 49.56  ? 719  LYS A CG  1 
ATOM   3324 C  CD  A LYS A 1 456 ? -15.005 -70.077 -34.249 0.34 49.29  ? 719  LYS A CD  1 
ATOM   3325 C  CD  B LYS A 1 456 ? -15.122 -71.156 -35.824 0.30 48.62  ? 719  LYS A CD  1 
ATOM   3326 C  CE  A LYS A 1 456 ? -15.323 -69.238 -33.030 0.34 48.43  ? 719  LYS A CE  1 
ATOM   3327 C  CE  B LYS A 1 456 ? -15.413 -72.492 -36.477 0.30 49.61  ? 719  LYS A CE  1 
ATOM   3328 N  NZ  A LYS A 1 456 ? -16.473 -69.793 -32.277 0.34 49.07  ? 719  LYS A NZ  1 
ATOM   3329 N  NZ  B LYS A 1 456 ? -15.157 -73.626 -35.559 0.30 50.26  ? 719  LYS A NZ  1 
ATOM   3330 N  N   . ASP A 1 457 ? -15.547 -66.592 -38.942 1.00 39.41  ? 720  ASP A N   1 
ATOM   3331 C  CA  . ASP A 1 457 ? -16.009 -66.373 -40.345 1.00 40.19  ? 720  ASP A CA  1 
ATOM   3332 C  C   . ASP A 1 457 ? -15.185 -65.322 -41.112 1.00 51.13  ? 720  ASP A C   1 
ATOM   3333 O  O   . ASP A 1 457 ? -15.623 -64.955 -42.205 1.00 42.75  ? 720  ASP A O   1 
ATOM   3334 C  CB  . ASP A 1 457 ? -17.497 -65.991 -40.398 1.00 44.82  ? 720  ASP A CB  1 
ATOM   3335 C  CG  . ASP A 1 457 ? -17.878 -64.629 -39.823 1.00 47.15  ? 720  ASP A CG  1 
ATOM   3336 O  OD1 . ASP A 1 457 ? -17.005 -63.714 -39.821 1.00 39.26  ? 720  ASP A OD1 1 
ATOM   3337 O  OD2 . ASP A 1 457 ? -19.061 -64.481 -39.417 1.00 44.57  ? 720  ASP A OD2 1 
ATOM   3338 N  N   . GLY A 1 458 ? -14.070 -64.812 -40.573 1.00 49.71  ? 721  GLY A N   1 
ATOM   3339 C  CA  . GLY A 1 458 ? -13.200 -63.864 -41.296 1.00 42.33  ? 721  GLY A CA  1 
ATOM   3340 C  C   . GLY A 1 458 ? -13.512 -62.400 -41.040 1.00 41.60  ? 721  GLY A C   1 
ATOM   3341 O  O   . GLY A 1 458 ? -12.694 -61.587 -41.424 1.00 45.32  ? 721  GLY A O   1 
ATOM   3342 N  N   . ARG A 1 459 ? -14.661 -62.017 -40.473 1.00 34.51  ? 722  ARG A N   1 
ATOM   3343 C  CA  . ARG A 1 459 ? -14.985 -60.581 -40.368 1.00 32.03  ? 722  ARG A CA  1 
ATOM   3344 C  C   . ARG A 1 459 ? -14.136 -60.003 -39.207 1.00 33.66  ? 722  ARG A C   1 
ATOM   3345 O  O   . ARG A 1 459 ? -13.714 -60.765 -38.323 1.00 35.02  ? 722  ARG A O   1 
ATOM   3346 C  CB  . ARG A 1 459 ? -16.486 -60.375 -40.215 1.00 36.34  ? 722  ARG A CB  1 
ATOM   3347 C  CG  . ARG A 1 459 ? -17.307 -60.767 -41.445 1.00 35.26  ? 722  ARG A CG  1 
ATOM   3348 C  CD  . ARG A 1 459 ? -18.782 -60.534 -41.228 1.00 35.45  ? 722  ARG A CD  1 
ATOM   3349 N  NE  . ARG A 1 459 ? -19.360 -61.454 -40.269 1.00 35.25  ? 722  ARG A NE  1 
ATOM   3350 C  CZ  . ARG A 1 459 ? -20.632 -61.466 -39.980 1.00 31.26  ? 722  ARG A CZ  1 
ATOM   3351 N  NH1 . ARG A 1 459 ? -21.436 -60.571 -40.529 1.00 36.82  ? 722  ARG A NH1 1 
ATOM   3352 N  NH2 . ARG A 1 459 ? -21.109 -62.365 -39.148 1.00 36.88  ? 722  ARG A NH2 1 
ATOM   3353 N  N   . VAL A 1 460 ? -13.883 -58.711 -39.241 1.00 36.37  ? 723  VAL A N   1 
ATOM   3354 C  CA  . VAL A 1 460 ? -12.952 -58.026 -38.297 1.00 34.76  ? 723  VAL A CA  1 
ATOM   3355 C  C   . VAL A 1 460 ? -13.716 -57.153 -37.311 1.00 31.96  ? 723  VAL A C   1 
ATOM   3356 O  O   . VAL A 1 460 ? -14.450 -56.203 -37.700 1.00 38.51  ? 723  VAL A O   1 
ATOM   3357 C  CB  . VAL A 1 460 ? -11.879 -57.230 -39.044 1.00 38.72  ? 723  VAL A CB  1 
ATOM   3358 C  CG1 . VAL A 1 460 ? -10.865 -56.645 -38.057 1.00 44.27  ? 723  VAL A CG1 1 
ATOM   3359 C  CG2 . VAL A 1 460 ? -11.171 -58.127 -40.031 1.00 37.16  ? 723  VAL A CG2 1 
ATOM   3360 N  N   . LEU A 1 461 ? -13.486 -57.423 -36.024 1.00 27.98  ? 724  LEU A N   1 
ATOM   3361 C  CA  . LEU A 1 461 ? -14.004 -56.577 -34.924 1.00 25.44  ? 724  LEU A CA  1 
ATOM   3362 C  C   . LEU A 1 461 ? -12.804 -55.775 -34.372 1.00 26.02  ? 724  LEU A C   1 
ATOM   3363 O  O   . LEU A 1 461 ? -11.709 -56.342 -34.232 1.00 29.69  ? 724  LEU A O   1 
ATOM   3364 C  CB  . LEU A 1 461 ? -14.613 -57.464 -33.855 1.00 26.87  ? 724  LEU A CB  1 
ATOM   3365 C  CG  . LEU A 1 461 ? -15.766 -58.351 -34.315 1.00 27.27  ? 724  LEU A CG  1 
ATOM   3366 C  CD1 . LEU A 1 461 ? -16.075 -59.353 -33.228 1.00 29.84  ? 724  LEU A CD1 1 
ATOM   3367 C  CD2 . LEU A 1 461 ? -16.975 -57.531 -34.673 1.00 27.95  ? 724  LEU A CD2 1 
ATOM   3368 N  N   . VAL A 1 462 ? -13.002 -54.499 -34.141 1.00 22.86  ? 725  VAL A N   1 
ATOM   3369 C  CA  . VAL A 1 462 ? -12.038 -53.682 -33.360 1.00 22.09  ? 725  VAL A CA  1 
ATOM   3370 C  C   . VAL A 1 462 ? -12.724 -53.358 -32.054 1.00 20.49  ? 725  VAL A C   1 
ATOM   3371 O  O   . VAL A 1 462 ? -13.735 -52.664 -32.068 1.00 21.23  ? 725  VAL A O   1 
ATOM   3372 C  CB  . VAL A 1 462 ? -11.600 -52.438 -34.126 1.00 22.85  ? 725  VAL A CB  1 
ATOM   3373 C  CG1 . VAL A 1 462 ? -10.697 -51.580 -33.233 1.00 23.51  ? 725  VAL A CG1 1 
ATOM   3374 C  CG2 . VAL A 1 462 ? -10.961 -52.833 -35.440 1.00 23.49  ? 725  VAL A CG2 1 
ATOM   3375 N  N   . VAL A 1 463 ? -12.214 -53.939 -30.968 1.00 20.31  ? 726  VAL A N   1 
ATOM   3376 C  CA  . VAL A 1 463 ? -12.898 -53.961 -29.656 1.00 20.44  ? 726  VAL A CA  1 
ATOM   3377 C  C   . VAL A 1 463 ? -12.157 -53.139 -28.614 1.00 19.83  ? 726  VAL A C   1 
ATOM   3378 O  O   . VAL A 1 463 ? -10.910 -53.082 -28.580 1.00 20.82  ? 726  VAL A O   1 
ATOM   3379 C  CB  . VAL A 1 463 ? -13.115 -55.412 -29.185 1.00 20.70  ? 726  VAL A CB  1 
ATOM   3380 C  CG1 . VAL A 1 463 ? -13.922 -56.183 -30.214 1.00 22.31  ? 726  VAL A CG1 1 
ATOM   3381 C  CG2 . VAL A 1 463 ? -11.783 -56.117 -28.939 1.00 19.87  ? 726  VAL A CG2 1 
ATOM   3382 N  N   . PRO A 1 464 ? -12.922 -52.495 -27.708 1.00 21.57  ? 727  PRO A N   1 
ATOM   3383 C  CA  . PRO A 1 464 ? -12.332 -51.753 -26.586 1.00 18.72  ? 727  PRO A CA  1 
ATOM   3384 C  C   . PRO A 1 464 ? -11.882 -52.680 -25.455 1.00 18.87  ? 727  PRO A C   1 
ATOM   3385 O  O   . PRO A 1 464 ? -12.498 -53.717 -25.192 1.00 19.54  ? 727  PRO A O   1 
ATOM   3386 C  CB  . PRO A 1 464 ? -13.494 -50.885 -26.127 1.00 20.21  ? 727  PRO A CB  1 
ATOM   3387 C  CG  . PRO A 1 464 ? -14.719 -51.762 -26.411 1.00 19.89  ? 727  PRO A CG  1 
ATOM   3388 C  CD  . PRO A 1 464 ? -14.399 -52.408 -27.748 1.00 21.52  ? 727  PRO A CD  1 
ATOM   3389 N  N   . CYS A 1 465 ? -10.865 -52.255 -24.717 1.00 17.66  ? 728  CYS A N   1 
ATOM   3390 C  CA  . CYS A 1 465 ? -10.259 -53.109 -23.664 1.00 18.03  ? 728  CYS A CA  1 
ATOM   3391 C  C   . CYS A 1 465 ? -9.592  -52.232 -22.596 1.00 20.07  ? 728  CYS A C   1 
ATOM   3392 O  O   . CYS A 1 465 ? -9.128  -51.143 -22.909 1.00 19.09  ? 728  CYS A O   1 
ATOM   3393 C  CB  . CYS A 1 465 ? -9.286  -54.141 -24.254 1.00 19.25  ? 728  CYS A CB  1 
ATOM   3394 S  SG  . CYS A 1 465 ? -8.756  -55.456 -23.094 1.00 19.32  ? 728  CYS A SG  1 
ATOM   3395 N  N   . ARG A 1 466 ? -9.569  -52.700 -21.352 1.00 20.52  ? 729  ARG A N   1 
ATOM   3396 C  CA  . ARG A 1 466 ? -8.702  -52.110 -20.317 1.00 21.77  ? 729  ARG A CA  1 
ATOM   3397 C  C   . ARG A 1 466 ? -8.425  -53.190 -19.296 1.00 20.86  ? 729  ARG A C   1 
ATOM   3398 O  O   . ARG A 1 466 ? -8.985  -54.291 -19.370 1.00 19.69  ? 729  ARG A O   1 
ATOM   3399 C  CB  . ARG A 1 466 ? -9.320  -50.871 -19.668 1.00 27.32  ? 729  ARG A CB  1 
ATOM   3400 C  CG  . ARG A 1 466 ? -10.639 -51.072 -18.983 1.00 31.30  ? 729  ARG A CG  1 
ATOM   3401 C  CD  . ARG A 1 466 ? -11.390 -49.748 -18.708 1.00 28.84  ? 729  ARG A CD  1 
ATOM   3402 N  NE  . ARG A 1 466 ? -10.755 -48.958 -17.673 1.00 26.96  ? 729  ARG A NE  1 
ATOM   3403 C  CZ  . ARG A 1 466 ? -11.270 -47.799 -17.231 1.00 28.87  ? 729  ARG A CZ  1 
ATOM   3404 N  NH1 . ARG A 1 466 ? -12.444 -47.361 -17.666 1.00 30.03  ? 729  ARG A NH1 1 
ATOM   3405 N  NH2 . ARG A 1 466 ? -10.635 -47.127 -16.317 1.00 30.18  ? 729  ARG A NH2 1 
ATOM   3406 N  N   . ASN A 1 467 ? -7.494  -52.918 -18.415 1.00 20.81  ? 730  ASN A N   1 
ATOM   3407 C  CA  . ASN A 1 467 ? -7.102  -53.949 -17.435 1.00 21.70  ? 730  ASN A CA  1 
ATOM   3408 C  C   . ASN A 1 467 ? -8.378  -54.428 -16.710 1.00 20.42  ? 730  ASN A C   1 
ATOM   3409 O  O   . ASN A 1 467 ? -9.103  -53.575 -16.180 1.00 19.62  ? 730  ASN A O   1 
ATOM   3410 C  CB  . ASN A 1 467 ? -6.073  -53.385 -16.468 1.00 22.85  ? 730  ASN A CB  1 
ATOM   3411 C  CG  . ASN A 1 467 ? -5.737  -54.426 -15.435 1.00 25.91  ? 730  ASN A CG  1 
ATOM   3412 O  OD1 . ASN A 1 467 ? -6.417  -54.502 -14.424 1.00 26.57  ? 730  ASN A OD1 1 
ATOM   3413 N  ND2 . ASN A 1 467 ? -4.748  -55.281 -15.734 1.00 31.09  ? 730  ASN A ND2 1 
ATOM   3414 N  N   . GLN A 1 468 ? -8.551  -55.739 -16.554 1.00 19.62  ? 731  GLN A N   1 
ATOM   3415 C  CA  . GLN A 1 468 ? -9.847  -56.287 -16.100 1.00 19.90  ? 731  GLN A CA  1 
ATOM   3416 C  C   . GLN A 1 468 ? -10.066 -55.958 -14.628 1.00 20.25  ? 731  GLN A C   1 
ATOM   3417 O  O   . GLN A 1 468 ? -11.236 -55.863 -14.214 1.00 19.90  ? 731  GLN A O   1 
ATOM   3418 C  CB  . GLN A 1 468 ? -9.902  -57.738 -16.475 1.00 22.42  ? 731  GLN A CB  1 
ATOM   3419 C  CG  . GLN A 1 468 ? -11.234 -58.373 -16.198 1.00 21.77  ? 731  GLN A CG  1 
ATOM   3420 C  CD  . GLN A 1 468 ? -11.204 -59.852 -16.441 1.00 20.97  ? 731  GLN A CD  1 
ATOM   3421 O  OE1 . GLN A 1 468 ? -11.585 -60.317 -17.514 1.00 22.31  ? 731  GLN A OE1 1 
ATOM   3422 N  NE2 . GLN A 1 468 ? -10.850 -60.600 -15.424 1.00 20.84  ? 731  GLN A NE2 1 
ATOM   3423 N  N   . ASP A 1 469 ? -8.998  -55.752 -13.842 1.00 21.69  ? 732  ASP A N   1 
ATOM   3424 C  CA  . ASP A 1 469 ? -9.200  -55.367 -12.421 1.00 23.26  ? 732  ASP A CA  1 
ATOM   3425 C  C   . ASP A 1 469 ? -9.968  -54.052 -12.357 1.00 23.35  ? 732  ASP A C   1 
ATOM   3426 O  O   . ASP A 1 469 ? -10.785 -53.844 -11.407 1.00 23.16  ? 732  ASP A O   1 
ATOM   3427 C  CB  . ASP A 1 469 ? -7.859  -55.225 -11.694 1.00 22.47  ? 732  ASP A CB  1 
ATOM   3428 C  CG  . ASP A 1 469 ? -7.152  -56.554 -11.485 1.00 26.58  ? 732  ASP A CG  1 
ATOM   3429 O  OD1 . ASP A 1 469 ? -7.772  -57.613 -11.660 1.00 23.72  ? 732  ASP A OD1 1 
ATOM   3430 O  OD2 . ASP A 1 469 ? -5.948  -56.505 -11.198 1.00 27.64  ? 732  ASP A OD2 1 
ATOM   3431 N  N   . GLU A 1 470 ? -9.669  -53.106 -13.250 1.00 20.80  ? 733  GLU A N   1 
ATOM   3432 C  CA  . GLU A 1 470 ? -10.352 -51.789 -13.258 1.00 20.54  ? 733  GLU A CA  1 
ATOM   3433 C  C   . GLU A 1 470 ? -11.851 -51.989 -13.559 1.00 19.36  ? 733  GLU A C   1 
ATOM   3434 O  O   . GLU A 1 470 ? -12.709 -51.291 -12.931 1.00 22.25  ? 733  GLU A O   1 
ATOM   3435 C  CB  . GLU A 1 470 ? -9.807  -50.900 -14.368 1.00 24.59  ? 733  GLU A CB  1 
ATOM   3436 C  CG  . GLU A 1 470 ? -8.340  -50.606 -14.232 1.00 30.77  ? 733  GLU A CG  1 
ATOM   3437 C  CD  . GLU A 1 470 ? -7.715  -49.791 -15.371 1.00 35.30  ? 733  GLU A CD  1 
ATOM   3438 O  OE1 . GLU A 1 470 ? -6.485  -49.729 -15.378 1.00 36.60  ? 733  GLU A OE1 1 
ATOM   3439 O  OE2 . GLU A 1 470 ? -8.424  -49.233 -16.239 1.00 31.45  ? 733  GLU A OE2 1 
ATOM   3440 N  N   . LEU A 1 471 ? -12.184 -52.865 -14.504 1.00 18.95  ? 734  LEU A N   1 
ATOM   3441 C  CA  . LEU A 1 471 ? -13.596 -53.112 -14.885 1.00 19.04  ? 734  LEU A CA  1 
ATOM   3442 C  C   . LEU A 1 471 ? -14.369 -53.766 -13.730 1.00 19.98  ? 734  LEU A C   1 
ATOM   3443 O  O   . LEU A 1 471 ? -15.482 -53.293 -13.367 1.00 20.66  ? 734  LEU A O   1 
ATOM   3444 C  CB  . LEU A 1 471 ? -13.652 -53.949 -16.154 1.00 19.22  ? 734  LEU A CB  1 
ATOM   3445 C  CG  . LEU A 1 471 ? -13.133 -53.220 -17.405 1.00 22.08  ? 734  LEU A CG  1 
ATOM   3446 C  CD1 . LEU A 1 471 ? -12.984 -54.161 -18.562 1.00 21.91  ? 734  LEU A CD1 1 
ATOM   3447 C  CD2 . LEU A 1 471 ? -14.021 -52.081 -17.810 1.00 24.55  ? 734  LEU A CD2 1 
ATOM   3448 N  N   . ILE A 1 472 ? -13.806 -54.810 -13.128 1.00 20.76  ? 735  ILE A N   1 
ATOM   3449 C  CA  . ILE A 1 472 ? -14.497 -55.507 -12.007 1.00 21.40  ? 735  ILE A CA  1 
ATOM   3450 C  C   . ILE A 1 472 ? -14.623 -54.570 -10.796 1.00 18.77  ? 735  ILE A C   1 
ATOM   3451 O  O   . ILE A 1 472 ? -15.701 -54.561 -10.142 1.00 19.99  ? 735  ILE A O   1 
ATOM   3452 C  CB  . ILE A 1 472 ? -13.753 -56.800 -11.703 1.00 20.26  ? 735  ILE A CB  1 
ATOM   3453 C  CG1 . ILE A 1 472 ? -13.880 -57.708 -12.921 1.00 23.39  ? 735  ILE A CG1 1 
ATOM   3454 C  CG2 . ILE A 1 472 ? -14.247 -57.422 -10.412 1.00 21.53  ? 735  ILE A CG2 1 
ATOM   3455 C  CD1 . ILE A 1 472 ? -13.244 -59.035 -12.799 1.00 29.18  ? 735  ILE A CD1 1 
ATOM   3456 N  N   . GLY A 1 473 ? -13.548 -53.849 -10.473 1.00 19.21  ? 736  GLY A N   1 
ATOM   3457 C  CA  . GLY A 1 473 ? -13.517 -52.947 -9.318  1.00 21.78  ? 736  GLY A CA  1 
ATOM   3458 C  C   . GLY A 1 473 ? -14.561 -51.847 -9.455  1.00 22.80  ? 736  GLY A C   1 
ATOM   3459 O  O   . GLY A 1 473 ? -15.219 -51.507 -8.447  1.00 22.46  ? 736  GLY A O   1 
ATOM   3460 N  N   . ARG A 1 474 ? -14.776 -51.339 -10.665 1.00 20.94  ? 737  ARG A N   1 
ATOM   3461 C  CA  . ARG A 1 474 ? -15.774 -50.240 -10.879 1.00 22.83  ? 737  ARG A CA  1 
ATOM   3462 C  C   . ARG A 1 474 ? -17.199 -50.806 -10.745 1.00 22.02  ? 737  ARG A C   1 
ATOM   3463 O  O   . ARG A 1 474 ? -18.070 -50.139 -10.169 1.00 22.99  ? 737  ARG A O   1 
ATOM   3464 C  CB  . ARG A 1 474 ? -15.596 -49.638 -12.286 1.00 25.64  ? 737  ARG A CB  1 
ATOM   3465 C  CG  . ARG A 1 474 ? -14.222 -49.061 -12.570 1.00 37.43  ? 737  ARG A CG  1 
ATOM   3466 C  CD  . ARG A 1 474 ? -13.887 -48.949 -14.081 1.00 44.80  ? 737  ARG A CD  1 
ATOM   3467 N  NE  . ARG A 1 474 ? -14.424 -47.647 -14.429 1.00 51.54  ? 737  ARG A NE  1 
ATOM   3468 C  CZ  . ARG A 1 474 ? -13.900 -46.497 -14.005 1.00 49.51  ? 737  ARG A CZ  1 
ATOM   3469 N  NH1 . ARG A 1 474 ? -14.493 -45.356 -14.309 1.00 54.32  ? 737  ARG A NH1 1 
ATOM   3470 N  NH2 . ARG A 1 474 ? -12.774 -46.492 -13.314 1.00 44.88  ? 737  ARG A NH2 1 
ATOM   3471 N  N   . ALA A 1 475 ? -17.468 -51.989 -11.269 1.00 20.76  ? 738  ALA A N   1 
ATOM   3472 C  CA  . ALA A 1 475 ? -18.821 -52.599 -11.265 1.00 20.33  ? 738  ALA A CA  1 
ATOM   3473 C  C   . ALA A 1 475 ? -19.217 -52.952 -9.826  1.00 23.93  ? 738  ALA A C   1 
ATOM   3474 O  O   . ALA A 1 475 ? -20.415 -53.076 -9.539  1.00 22.83  ? 738  ALA A O   1 
ATOM   3475 C  CB  . ALA A 1 475 ? -18.857 -53.802 -12.185 1.00 20.38  ? 738  ALA A CB  1 
ATOM   3476 N  N   . ARG A 1 476 ? -18.253 -53.116 -8.924  1.00 20.26  ? 739  ARG A N   1 
ATOM   3477 C  CA  . ARG A 1 476 ? -18.503 -53.479 -7.503  1.00 22.10  ? 739  ARG A CA  1 
ATOM   3478 C  C   . ARG A 1 476 ? -18.803 -52.233 -6.660  1.00 23.63  ? 739  ARG A C   1 
ATOM   3479 O  O   . ARG A 1 476 ? -19.131 -52.412 -5.453  1.00 23.67  ? 739  ARG A O   1 
ATOM   3480 C  CB  . ARG A 1 476 ? -17.337 -54.283 -6.915  1.00 21.44  ? 739  ARG A CB  1 
ATOM   3481 C  CG  . ARG A 1 476 ? -17.355 -55.692 -7.474  1.00 21.42  ? 739  ARG A CG  1 
ATOM   3482 C  CD  . ARG A 1 476 ? -16.053 -56.480 -7.327  1.00 25.24  ? 739  ARG A CD  1 
ATOM   3483 N  NE  . ARG A 1 476 ? -15.641 -56.687 -5.972  1.00 23.63  ? 739  ARG A NE  1 
ATOM   3484 C  CZ  . ARG A 1 476 ? -15.283 -57.828 -5.421  1.00 21.14  ? 739  ARG A CZ  1 
ATOM   3485 N  NH1 . ARG A 1 476 ? -15.466 -59.000 -5.985  1.00 21.53  ? 739  ARG A NH1 1 
ATOM   3486 N  NH2 . ARG A 1 476 ? -14.778 -57.784 -4.219  1.00 21.94  ? 739  ARG A NH2 1 
ATOM   3487 N  N   . ILE A 1 477 ? -18.864 -51.065 -7.295  1.00 25.17  ? 740  ILE A N   1 
ATOM   3488 C  CA  . ILE A 1 477 ? -19.079 -49.799 -6.541  1.00 31.05  ? 740  ILE A CA  1 
ATOM   3489 C  C   . ILE A 1 477 ? -20.386 -49.106 -6.907  1.00 33.62  ? 740  ILE A C   1 
ATOM   3490 O  O   . ILE A 1 477 ? -20.794 -49.194 -8.068  1.00 29.79  ? 740  ILE A O   1 
ATOM   3491 C  CB  . ILE A 1 477 ? -17.896 -48.828 -6.723  1.00 32.39  ? 740  ILE A CB  1 
ATOM   3492 C  CG1 . ILE A 1 477 ? -16.621 -49.356 -6.064  1.00 33.82  ? 740  ILE A CG1 1 
ATOM   3493 C  CG2 . ILE A 1 477 ? -18.258 -47.443 -6.213  1.00 39.96  ? 740  ILE A CG2 1 
ATOM   3494 C  CD1 . ILE A 1 477 ? -15.395 -48.538 -6.376  1.00 36.64  ? 740  ILE A CD1 1 
ATOM   3495 N  N   A SER A 1 478 ? -21.116 -48.630 -5.895  0.25 35.77  ? 741  SER A N   1 
ATOM   3496 N  N   B SER A 1 478 ? -21.117 -48.631 -5.895  0.25 36.64  ? 741  SER A N   1 
ATOM   3497 C  CA  A SER A 1 478 ? -22.376 -47.886 -6.148  0.25 39.32  ? 741  SER A CA  1 
ATOM   3498 C  CA  B SER A 1 478 ? -22.374 -47.883 -6.154  0.25 40.63  ? 741  SER A CA  1 
ATOM   3499 C  C   A SER A 1 478 ? -22.246 -46.518 -5.478  0.25 43.04  ? 741  SER A C   1 
ATOM   3500 C  C   B SER A 1 478 ? -22.262 -46.521 -5.468  0.25 44.10  ? 741  SER A C   1 
ATOM   3501 O  O   A SER A 1 478 ? -21.346 -46.382 -4.626  0.25 43.34  ? 741  SER A O   1 
ATOM   3502 O  O   B SER A 1 478 ? -21.375 -46.390 -4.602  0.25 46.55  ? 741  SER A O   1 
ATOM   3503 C  CB  A SER A 1 478 ? -23.561 -48.638 -5.614  0.25 38.92  ? 741  SER A CB  1 
ATOM   3504 C  CB  B SER A 1 478 ? -23.579 -48.641 -5.667  0.25 40.49  ? 741  SER A CB  1 
ATOM   3505 O  OG  A SER A 1 478 ? -24.732 -47.841 -5.683  0.25 37.20  ? 741  SER A OG  1 
ATOM   3506 O  OG  B SER A 1 478 ? -23.476 -48.918 -4.280  0.25 39.67  ? 741  SER A OG  1 
ATOM   3507 N  N   . GLN A 1 479 ? -22.844 -45.490 -6.084  0.34 46.86  ? 742  GLN A N   1 
ATOM   3508 C  CA  . GLN A 1 479 ? -22.781 -44.125 -5.504  0.34 49.17  ? 742  GLN A CA  1 
ATOM   3509 C  C   . GLN A 1 479 ? -24.151 -43.757 -4.936  0.34 50.50  ? 742  GLN A C   1 
ATOM   3510 O  O   . GLN A 1 479 ? -25.149 -43.953 -5.645  0.34 47.30  ? 742  GLN A O   1 
ATOM   3511 C  CB  . GLN A 1 479 ? -22.338 -43.120 -6.568  0.34 52.14  ? 742  GLN A CB  1 
ATOM   3512 C  CG  . GLN A 1 479 ? -21.056 -43.519 -7.284  0.34 53.25  ? 742  GLN A CG  1 
ATOM   3513 C  CD  . GLN A 1 479 ? -19.858 -43.533 -6.367  0.34 53.46  ? 742  GLN A CD  1 
ATOM   3514 O  OE1 . GLN A 1 479 ? -19.873 -42.959 -5.281  0.34 54.62  ? 742  GLN A OE1 1 
ATOM   3515 N  NE2 . GLN A 1 479 ? -18.796 -44.187 -6.809  0.34 54.11  ? 742  GLN A NE2 1 
ATOM   3516 N  N   . GLY A 1 480 ? -24.194 -43.277 -3.692  1.00 51.71  ? 743  GLY A N   1 
ATOM   3517 C  CA  . GLY A 1 480 ? -25.474 -42.791 -3.139  1.00 55.77  ? 743  GLY A CA  1 
ATOM   3518 C  C   . GLY A 1 480 ? -26.096 -43.614 -2.024  1.00 54.41  ? 743  GLY A C   1 
ATOM   3519 O  O   . GLY A 1 480 ? -25.639 -44.738 -1.799  1.00 55.71  ? 743  GLY A O   1 
ATOM   3520 N  N   . ALA A 1 481 ? -27.130 -43.067 -1.375  1.00 55.38  ? 744  ALA A N   1 
ATOM   3521 C  CA  . ALA A 1 481 ? -27.840 -43.718 -0.246  1.00 49.02  ? 744  ALA A CA  1 
ATOM   3522 C  C   . ALA A 1 481 ? -29.219 -44.222 -0.679  1.00 44.55  ? 744  ALA A C   1 
ATOM   3523 O  O   . ALA A 1 481 ? -29.718 -43.807 -1.732  1.00 41.84  ? 744  ALA A O   1 
ATOM   3524 C  CB  . ALA A 1 481 ? -28.008 -42.742 0.906   1.00 53.34  ? 744  ALA A CB  1 
ATOM   3525 N  N   . GLY A 1 482 ? -29.827 -45.064 0.155   1.00 38.91  ? 745  GLY A N   1 
ATOM   3526 C  CA  . GLY A 1 482 ? -31.224 -45.515 0.003   1.00 38.04  ? 745  GLY A CA  1 
ATOM   3527 C  C   . GLY A 1 482 ? -31.366 -46.462 -1.167  1.00 39.90  ? 745  GLY A C   1 
ATOM   3528 O  O   . GLY A 1 482 ? -32.443 -46.461 -1.796  1.00 44.49  ? 745  GLY A O   1 
ATOM   3529 N  N   . TRP A 1 483 ? -30.317 -47.229 -1.528  1.00 31.23  ? 746  TRP A N   1 
ATOM   3530 C  CA  . TRP A 1 483 ? -30.512 -48.236 -2.603  1.00 30.33  ? 746  TRP A CA  1 
ATOM   3531 C  C   . TRP A 1 483 ? -31.286 -49.431 -2.043  1.00 29.32  ? 746  TRP A C   1 
ATOM   3532 O  O   . TRP A 1 483 ? -30.822 -50.107 -1.112  1.00 26.48  ? 746  TRP A O   1 
ATOM   3533 C  CB  . TRP A 1 483 ? -29.201 -48.702 -3.218  1.00 37.87  ? 746  TRP A CB  1 
ATOM   3534 C  CG  . TRP A 1 483 ? -28.432 -47.698 -4.016  1.00 42.93  ? 746  TRP A CG  1 
ATOM   3535 C  CD1 . TRP A 1 483 ? -27.644 -46.696 -3.516  1.00 51.24  ? 746  TRP A CD1 1 
ATOM   3536 C  CD2 . TRP A 1 483 ? -28.249 -47.675 -5.441  1.00 43.70  ? 746  TRP A CD2 1 
ATOM   3537 N  NE1 . TRP A 1 483 ? -27.044 -46.000 -4.532  1.00 52.23  ? 746  TRP A NE1 1 
ATOM   3538 C  CE2 . TRP A 1 483 ? -27.379 -46.592 -5.725  1.00 49.70  ? 746  TRP A CE2 1 
ATOM   3539 C  CE3 . TRP A 1 483 ? -28.733 -48.450 -6.502  1.00 36.17  ? 746  TRP A CE3 1 
ATOM   3540 C  CZ2 . TRP A 1 483 ? -27.003 -46.271 -7.026  1.00 44.27  ? 746  TRP A CZ2 1 
ATOM   3541 C  CZ3 . TRP A 1 483 ? -28.359 -48.129 -7.784  1.00 40.50  ? 746  TRP A CZ3 1 
ATOM   3542 C  CH2 . TRP A 1 483 ? -27.520 -47.046 -8.040  1.00 44.40  ? 746  TRP A CH2 1 
ATOM   3543 N  N   . SER A 1 484 ? -32.431 -49.743 -2.623  1.00 26.41  ? 747  SER A N   1 
ATOM   3544 C  CA  . SER A 1 484 ? -33.108 -51.022 -2.363  1.00 24.60  ? 747  SER A CA  1 
ATOM   3545 C  C   . SER A 1 484 ? -32.273 -52.173 -2.938  1.00 21.74  ? 747  SER A C   1 
ATOM   3546 O  O   . SER A 1 484 ? -31.391 -51.886 -3.771  1.00 23.99  ? 747  SER A O   1 
ATOM   3547 C  CB  . SER A 1 484 ? -34.529 -50.997 -2.937  1.00 27.23  ? 747  SER A CB  1 
ATOM   3548 O  OG  . SER A 1 484 ? -34.484 -51.070 -4.347  1.00 25.20  ? 747  SER A OG  1 
ATOM   3549 N  N   . LEU A 1 485 ? -32.602 -53.419 -2.569  1.00 22.22  ? 748  LEU A N   1 
ATOM   3550 C  CA  . LEU A 1 485 ? -32.000 -54.624 -3.213  1.00 23.71  ? 748  LEU A CA  1 
ATOM   3551 C  C   . LEU A 1 485 ? -32.336 -54.670 -4.705  1.00 25.61  ? 748  LEU A C   1 
ATOM   3552 O  O   . LEU A 1 485 ? -31.434 -54.922 -5.510  1.00 23.80  ? 748  LEU A O   1 
ATOM   3553 C  CB  . LEU A 1 485 ? -32.463 -55.907 -2.533  1.00 24.10  ? 748  LEU A CB  1 
ATOM   3554 C  CG  . LEU A 1 485 ? -31.803 -57.177 -3.057  1.00 28.81  ? 748  LEU A CG  1 
ATOM   3555 C  CD1 . LEU A 1 485 ? -30.277 -57.027 -3.136  1.00 29.53  ? 748  LEU A CD1 1 
ATOM   3556 C  CD2 . LEU A 1 485 ? -32.213 -58.387 -2.228  1.00 29.04  ? 748  LEU A CD2 1 
ATOM   3557 N  N   . ARG A 1 486 ? -33.587 -54.342 -5.087  1.00 24.02  ? 749  ARG A N   1 
ATOM   3558 C  CA  . ARG A 1 486 ? -33.965 -54.306 -6.514  1.00 23.61  ? 749  ARG A CA  1 
ATOM   3559 C  C   . ARG A 1 486 ? -33.128 -53.260 -7.266  1.00 22.75  ? 749  ARG A C   1 
ATOM   3560 O  O   . ARG A 1 486 ? -32.631 -53.580 -8.338  1.00 23.12  ? 749  ARG A O   1 
ATOM   3561 C  CB  . ARG A 1 486 ? -35.465 -54.053 -6.674  1.00 24.28  ? 749  ARG A CB  1 
ATOM   3562 C  CG  . ARG A 1 486 ? -35.872 -53.759 -8.107  1.00 26.82  ? 749  ARG A CG  1 
ATOM   3563 C  CD  . ARG A 1 486 ? -37.382 -53.864 -8.154  1.00 28.31  ? 749  ARG A CD  1 
ATOM   3564 N  NE  . ARG A 1 486 ? -37.893 -53.714 -9.513  1.00 28.13  ? 749  ARG A NE  1 
ATOM   3565 C  CZ  . ARG A 1 486 ? -39.058 -54.225 -9.892  1.00 27.57  ? 749  ARG A CZ  1 
ATOM   3566 N  NH1 . ARG A 1 486 ? -39.764 -54.931 -9.019  1.00 26.11  ? 749  ARG A NH1 1 
ATOM   3567 N  NH2 . ARG A 1 486 ? -39.472 -54.072 -11.136 1.00 28.55  ? 749  ARG A NH2 1 
ATOM   3568 N  N   . GLU A 1 487 ? -32.956 -52.062 -6.739  1.00 22.88  ? 750  GLU A N   1 
ATOM   3569 C  CA  . GLU A 1 487 ? -32.184 -51.018 -7.456  1.00 25.44  ? 750  GLU A CA  1 
ATOM   3570 C  C   . GLU A 1 487 ? -30.690 -51.426 -7.551  1.00 24.12  ? 750  GLU A C   1 
ATOM   3571 O  O   . GLU A 1 487 ? -30.064 -51.207 -8.631  1.00 21.67  ? 750  GLU A O   1 
ATOM   3572 C  CB  . GLU A 1 487 ? -32.260 -49.666 -6.764  1.00 32.20  ? 750  GLU A CB  1 
ATOM   3573 C  CG  . GLU A 1 487 ? -31.896 -48.508 -7.684  1.00 42.91  ? 750  GLU A CG  1 
ATOM   3574 C  CD  . GLU A 1 487 ? -31.847 -47.102 -7.080  1.00 51.59  ? 750  GLU A CD  1 
ATOM   3575 O  OE1 . GLU A 1 487 ? -32.021 -46.970 -5.822  1.00 51.06  ? 750  GLU A OE1 1 
ATOM   3576 O  OE2 . GLU A 1 487 ? -31.657 -46.123 -7.872  1.00 55.91  ? 750  GLU A OE2 1 
ATOM   3577 N  N   . THR A 1 488 ? -30.153 -52.036 -6.490  1.00 23.41  ? 751  THR A N   1 
ATOM   3578 C  CA  . THR A 1 488 ? -28.755 -52.571 -6.515  1.00 21.82  ? 751  THR A CA  1 
ATOM   3579 C  C   . THR A 1 488 ? -28.636 -53.647 -7.607  1.00 21.43  ? 751  THR A C   1 
ATOM   3580 O  O   . THR A 1 488 ? -27.641 -53.612 -8.440  1.00 22.21  ? 751  THR A O   1 
ATOM   3581 C  CB  . THR A 1 488 ? -28.397 -53.128 -5.149  1.00 22.56  ? 751  THR A CB  1 
ATOM   3582 O  OG1 . THR A 1 488 ? -28.615 -52.119 -4.159  1.00 25.24  ? 751  THR A OG1 1 
ATOM   3583 C  CG2 . THR A 1 488 ? -26.969 -53.617 -5.120  1.00 20.73  ? 751  THR A CG2 1 
ATOM   3584 N  N   . ALA A 1 489 ? -29.566 -54.605 -7.664  1.00 21.23  ? 752  ALA A N   1 
ATOM   3585 C  CA  . ALA A 1 489 ? -29.600 -55.644 -8.706  1.00 23.06  ? 752  ALA A CA  1 
ATOM   3586 C  C   . ALA A 1 489 ? -29.639 -55.015 -10.111 1.00 25.39  ? 752  ALA A C   1 
ATOM   3587 O  O   . ALA A 1 489 ? -28.959 -55.530 -11.019 1.00 21.53  ? 752  ALA A O   1 
ATOM   3588 C  CB  . ALA A 1 489 ? -30.739 -56.605 -8.478  1.00 21.63  ? 752  ALA A CB  1 
ATOM   3589 N  N   . CYS A 1 490 ? -30.467 -53.985 -10.330 1.00 22.90  ? 753  CYS A N   1 
ATOM   3590 C  CA  . CYS A 1 490 ? -30.652 -53.406 -11.676 1.00 20.37  ? 753  CYS A CA  1 
ATOM   3591 C  C   . CYS A 1 490 ? -29.362 -52.649 -12.078 1.00 21.24  ? 753  CYS A C   1 
ATOM   3592 O  O   . CYS A 1 490 ? -29.069 -52.635 -13.228 1.00 23.68  ? 753  CYS A O   1 
ATOM   3593 C  CB  . CYS A 1 490 ? -31.853 -52.474 -11.712 1.00 22.31  ? 753  CYS A CB  1 
ATOM   3594 S  SG  . CYS A 1 490 ? -33.405 -53.432 -11.595 1.00 26.81  ? 753  CYS A SG  1 
ATOM   3595 N  N   . LEU A 1 491 ? -28.633 -52.030 -11.139 1.00 19.64  ? 754  LEU A N   1 
ATOM   3596 C  CA  . LEU A 1 491 ? -27.299 -51.443 -11.433 1.00 20.41  ? 754  LEU A CA  1 
ATOM   3597 C  C   . LEU A 1 491 ? -26.287 -52.534 -11.775 1.00 22.42  ? 754  LEU A C   1 
ATOM   3598 O  O   . LEU A 1 491 ? -25.566 -52.388 -12.752 1.00 22.03  ? 754  LEU A O   1 
ATOM   3599 C  CB  . LEU A 1 491 ? -26.828 -50.628 -10.232 1.00 23.44  ? 754  LEU A CB  1 
ATOM   3600 C  CG  . LEU A 1 491 ? -25.475 -49.947 -10.437 1.00 25.44  ? 754  LEU A CG  1 
ATOM   3601 C  CD1 . LEU A 1 491 ? -25.508 -49.001 -11.642 1.00 25.13  ? 754  LEU A CD1 1 
ATOM   3602 C  CD2 . LEU A 1 491 ? -25.010 -49.264 -9.170  1.00 28.32  ? 754  LEU A CD2 1 
ATOM   3603 N  N   . GLY A 1 492 ? -26.328 -53.678 -11.090 1.00 21.88  ? 755  GLY A N   1 
ATOM   3604 C  CA  . GLY A 1 492 ? -25.477 -54.804 -11.482 1.00 21.20  ? 755  GLY A CA  1 
ATOM   3605 C  C   . GLY A 1 492 ? -25.767 -55.288 -12.880 1.00 21.37  ? 755  GLY A C   1 
ATOM   3606 O  O   . GLY A 1 492 ? -24.832 -55.543 -13.658 1.00 20.87  ? 755  GLY A O   1 
ATOM   3607 N  N   . LYS A 1 493 ? -27.047 -55.353 -13.242 1.00 20.73  ? 756  LYS A N   1 
ATOM   3608 C  CA  . LYS A 1 493 ? -27.485 -55.746 -14.590 1.00 19.91  ? 756  LYS A CA  1 
ATOM   3609 C  C   . LYS A 1 493 ? -26.971 -54.754 -15.640 1.00 19.65  ? 756  LYS A C   1 
ATOM   3610 O  O   . LYS A 1 493 ? -26.582 -55.222 -16.734 1.00 21.19  ? 756  LYS A O   1 
ATOM   3611 C  CB  . LYS A 1 493 ? -29.024 -55.883 -14.620 1.00 20.53  ? 756  LYS A CB  1 
ATOM   3612 C  CG  . LYS A 1 493 ? -29.532 -56.425 -15.946 1.00 23.83  ? 756  LYS A CG  1 
ATOM   3613 C  CD  . LYS A 1 493 ? -31.006 -56.828 -15.819 1.00 24.51  ? 756  LYS A CD  1 
ATOM   3614 C  CE  . LYS A 1 493 ? -31.607 -57.286 -17.114 1.00 26.90  ? 756  LYS A CE  1 
ATOM   3615 N  NZ  . LYS A 1 493 ? -32.982 -57.812 -16.865 1.00 27.12  ? 756  LYS A NZ  1 
ATOM   3616 N  N   . SER A 1 494 ? -26.980 -53.455 -15.369 1.00 21.57  ? 757  SER A N   1 
ATOM   3617 C  CA  . SER A 1 494 ? -26.415 -52.433 -16.284 1.00 23.40  ? 757  SER A CA  1 
ATOM   3618 C  C   . SER A 1 494 ? -24.942 -52.779 -16.562 1.00 22.14  ? 757  SER A C   1 
ATOM   3619 O  O   . SER A 1 494 ? -24.564 -52.796 -17.755 1.00 20.35  ? 757  SER A O   1 
ATOM   3620 C  CB  . SER A 1 494 ? -26.480 -51.032 -15.771 1.00 27.25  ? 757  SER A CB  1 
ATOM   3621 O  OG  . SER A 1 494 ? -27.826 -50.670 -15.522 1.00 34.67  ? 757  SER A OG  1 
ATOM   3622 N  N   . TYR A 1 495 ? -24.143 -53.026 -15.518 1.00 20.25  ? 758  TYR A N   1 
ATOM   3623 C  CA  . TYR A 1 495 ? -22.711 -53.386 -15.755 1.00 20.87  ? 758  TYR A CA  1 
ATOM   3624 C  C   . TYR A 1 495 ? -22.613 -54.666 -16.578 1.00 19.86  ? 758  TYR A C   1 
ATOM   3625 O  O   . TYR A 1 495 ? -21.779 -54.754 -17.499 1.00 20.15  ? 758  TYR A O   1 
ATOM   3626 C  CB  . TYR A 1 495 ? -21.928 -53.486 -14.439 1.00 20.20  ? 758  TYR A CB  1 
ATOM   3627 C  CG  . TYR A 1 495 ? -21.459 -52.156 -13.937 1.00 21.26  ? 758  TYR A CG  1 
ATOM   3628 C  CD1 . TYR A 1 495 ? -20.324 -51.566 -14.488 1.00 22.46  ? 758  TYR A CD1 1 
ATOM   3629 C  CD2 . TYR A 1 495 ? -22.121 -51.485 -12.926 1.00 23.29  ? 758  TYR A CD2 1 
ATOM   3630 C  CE1 . TYR A 1 495 ? -19.908 -50.322 -14.083 1.00 23.00  ? 758  TYR A CE1 1 
ATOM   3631 C  CE2 . TYR A 1 495 ? -21.681 -50.245 -12.480 1.00 24.00  ? 758  TYR A CE2 1 
ATOM   3632 C  CZ  . TYR A 1 495 ? -20.594 -49.645 -13.099 1.00 27.15  ? 758  TYR A CZ  1 
ATOM   3633 O  OH  . TYR A 1 495 ? -20.136 -48.411 -12.718 1.00 28.64  ? 758  TYR A OH  1 
ATOM   3634 N  N   . ALA A 1 496 ? -23.375 -55.695 -16.233 1.00 19.37  ? 759  ALA A N   1 
ATOM   3635 C  CA  . ALA A 1 496 ? -23.349 -56.998 -16.931 1.00 19.50  ? 759  ALA A CA  1 
ATOM   3636 C  C   . ALA A 1 496 ? -23.624 -56.792 -18.419 1.00 19.05  ? 759  ALA A C   1 
ATOM   3637 O  O   . ALA A 1 496 ? -22.922 -57.398 -19.284 1.00 19.26  ? 759  ALA A O   1 
ATOM   3638 C  CB  . ALA A 1 496 ? -24.326 -57.960 -16.282 1.00 20.25  ? 759  ALA A CB  1 
ATOM   3639 N  N   . GLN A 1 497 ? -24.683 -56.053 -18.744 1.00 19.36  ? 760  GLN A N   1 
ATOM   3640 C  CA  . GLN A 1 497 ? -25.050 -55.841 -20.161 1.00 20.04  ? 760  GLN A CA  1 
ATOM   3641 C  C   . GLN A 1 497 ? -23.970 -54.997 -20.892 1.00 20.11  ? 760  GLN A C   1 
ATOM   3642 O  O   . GLN A 1 497 ? -23.652 -55.322 -22.079 1.00 21.26  ? 760  GLN A O   1 
ATOM   3643 C  CB  . GLN A 1 497 ? -26.463 -55.292 -20.292 1.00 23.52  ? 760  GLN A CB  1 
ATOM   3644 C  CG  . GLN A 1 497 ? -27.484 -56.319 -19.815 1.00 24.82  ? 760  GLN A CG  1 
ATOM   3645 C  CD  . GLN A 1 497 ? -28.947 -56.054 -20.139 1.00 27.32  ? 760  GLN A CD  1 
ATOM   3646 O  OE1 . GLN A 1 497 ? -29.755 -56.974 -20.055 1.00 25.94  ? 760  GLN A OE1 1 
ATOM   3647 N  NE2 . GLN A 1 497 ? -29.267 -54.839 -20.489 1.00 25.30  ? 760  GLN A NE2 1 
ATOM   3648 N  N   . MET A 1 498 ? -23.327 -54.056 -20.201 1.00 20.32  ? 761  MET A N   1 
ATOM   3649 C  CA  . MET A 1 498 ? -22.207 -53.306 -20.807 1.00 19.97  ? 761  MET A CA  1 
ATOM   3650 C  C   . MET A 1 498 ? -21.084 -54.276 -21.137 1.00 18.48  ? 761  MET A C   1 
ATOM   3651 O  O   . MET A 1 498 ? -20.499 -54.224 -22.248 1.00 20.45  ? 761  MET A O   1 
ATOM   3652 C  CB  . MET A 1 498 ? -21.698 -52.194 -19.888 1.00 21.80  ? 761  MET A CB  1 
ATOM   3653 C  CG  . MET A 1 498 ? -20.393 -51.485 -20.428 1.00 24.71  ? 761  MET A CG  1 
ATOM   3654 S  SD  . MET A 1 498 ? -19.889 -50.201 -19.300 1.00 31.12  ? 761  MET A SD  1 
ATOM   3655 C  CE  . MET A 1 498 ? -18.963 -51.224 -18.164 1.00 31.15  ? 761  MET A CE  1 
ATOM   3656 N  N   . TRP A 1 499 ? -20.750 -55.163 -20.213 1.00 19.32  ? 762  TRP A N   1 
ATOM   3657 C  CA  . TRP A 1 499 ? -19.698 -56.170 -20.450 1.00 19.24  ? 762  TRP A CA  1 
ATOM   3658 C  C   . TRP A 1 499 ? -20.024 -57.074 -21.657 1.00 22.08  ? 762  TRP A C   1 
ATOM   3659 O  O   . TRP A 1 499 ? -19.140 -57.338 -22.457 1.00 20.37  ? 762  TRP A O   1 
ATOM   3660 C  CB  . TRP A 1 499 ? -19.477 -56.999 -19.178 1.00 19.58  ? 762  TRP A CB  1 
ATOM   3661 C  CG  . TRP A 1 499 ? -18.854 -56.300 -18.019 1.00 19.55  ? 762  TRP A CG  1 
ATOM   3662 C  CD1 . TRP A 1 499 ? -18.341 -55.048 -17.982 1.00 21.10  ? 762  TRP A CD1 1 
ATOM   3663 C  CD2 . TRP A 1 499 ? -18.689 -56.832 -16.691 1.00 19.65  ? 762  TRP A CD2 1 
ATOM   3664 N  NE1 . TRP A 1 499 ? -17.924 -54.749 -16.726 1.00 20.51  ? 762  TRP A NE1 1 
ATOM   3665 C  CE2 . TRP A 1 499 ? -18.058 -55.849 -15.929 1.00 18.87  ? 762  TRP A CE2 1 
ATOM   3666 C  CE3 . TRP A 1 499 ? -19.011 -58.033 -16.071 1.00 21.57  ? 762  TRP A CE3 1 
ATOM   3667 C  CZ2 . TRP A 1 499 ? -17.701 -56.029 -14.605 1.00 21.08  ? 762  TRP A CZ2 1 
ATOM   3668 C  CZ3 . TRP A 1 499 ? -18.728 -58.197 -14.729 1.00 22.52  ? 762  TRP A CZ3 1 
ATOM   3669 C  CH2 . TRP A 1 499 ? -18.081 -57.204 -14.003 1.00 21.75  ? 762  TRP A CH2 1 
ATOM   3670 N  N   A SER A 1 500 ? -21.269 -57.554 -21.766 0.25 20.56  ? 763  SER A N   1 
ATOM   3671 N  N   B SER A 1 500 ? -21.280 -57.516 -21.796 0.25 21.56  ? 763  SER A N   1 
ATOM   3672 C  CA  A SER A 1 500 ? -21.707 -58.401 -22.904 0.25 21.33  ? 763  SER A CA  1 
ATOM   3673 C  CA  B SER A 1 500 ? -21.695 -58.419 -22.898 0.25 23.05  ? 763  SER A CA  1 
ATOM   3674 C  C   A SER A 1 500 ? -21.461 -57.656 -24.222 0.25 19.88  ? 763  SER A C   1 
ATOM   3675 C  C   B SER A 1 500 ? -21.596 -57.692 -24.251 0.25 21.72  ? 763  SER A C   1 
ATOM   3676 O  O   A SER A 1 500 ? -20.979 -58.277 -25.163 0.25 19.28  ? 763  SER A O   1 
ATOM   3677 O  O   B SER A 1 500 ? -21.369 -58.380 -25.270 0.25 23.93  ? 763  SER A O   1 
ATOM   3678 C  CB  A SER A 1 500 ? -23.142 -58.844 -22.761 0.25 21.42  ? 763  SER A CB  1 
ATOM   3679 C  CB  B SER A 1 500 ? -23.065 -59.009 -22.649 0.25 23.75  ? 763  SER A CB  1 
ATOM   3680 O  OG  A SER A 1 500 ? -23.324 -59.507 -21.515 0.25 23.18  ? 763  SER A OG  1 
ATOM   3681 O  OG  B SER A 1 500 ? -24.081 -58.043 -22.851 0.25 26.65  ? 763  SER A OG  1 
ATOM   3682 N  N   . LEU A 1 501 ? -21.787 -56.362 -24.269 1.00 21.85  ? 764  LEU A N   1 
ATOM   3683 C  CA  . LEU A 1 501 ? -21.707 -55.569 -25.518 1.00 22.78  ? 764  LEU A CA  1 
ATOM   3684 C  C   . LEU A 1 501 ? -20.285 -55.083 -25.833 1.00 26.27  ? 764  LEU A C   1 
ATOM   3685 O  O   . LEU A 1 501 ? -19.934 -55.058 -27.012 1.00 25.89  ? 764  LEU A O   1 
ATOM   3686 C  CB  . LEU A 1 501 ? -22.704 -54.411 -25.413 1.00 26.58  ? 764  LEU A CB  1 
ATOM   3687 C  CG  . LEU A 1 501 ? -23.051 -53.749 -26.733 1.00 36.81  ? 764  LEU A CG  1 
ATOM   3688 C  CD1 . LEU A 1 501 ? -23.599 -54.779 -27.726 1.00 39.64  ? 764  LEU A CD1 1 
ATOM   3689 C  CD2 . LEU A 1 501 ? -24.089 -52.647 -26.493 1.00 42.17  ? 764  LEU A CD2 1 
ATOM   3690 N  N   . MET A 1 502 ? -19.487 -54.680 -24.845 1.00 21.95  ? 765  MET A N   1 
ATOM   3691 C  CA  . MET A 1 502 ? -18.214 -53.987 -25.077 1.00 21.85  ? 765  MET A CA  1 
ATOM   3692 C  C   . MET A 1 502 ? -17.049 -54.955 -24.805 1.00 22.18  ? 765  MET A C   1 
ATOM   3693 O  O   . MET A 1 502 ? -16.044 -54.824 -25.483 1.00 19.58  ? 765  MET A O   1 
ATOM   3694 C  CB  . MET A 1 502 ? -18.087 -52.754 -24.179 1.00 24.26  ? 765  MET A CB  1 
ATOM   3695 C  CG  . MET A 1 502 ? -19.157 -51.674 -24.462 1.00 27.63  ? 765  MET A CG  1 
ATOM   3696 S  SD  . MET A 1 502 ? -19.043 -51.067 -26.178 1.00 33.14  ? 765  MET A SD  1 
ATOM   3697 C  CE  . MET A 1 502 ? -20.431 -51.805 -26.982 1.00 40.21  ? 765  MET A CE  1 
ATOM   3698 N  N   . TYR A 1 503 ? -17.183 -55.847 -23.830 1.00 19.28  ? 766  TYR A N   1 
ATOM   3699 C  CA  . TYR A 1 503 ? -16.039 -56.632 -23.301 1.00 20.39  ? 766  TYR A CA  1 
ATOM   3700 C  C   . TYR A 1 503 ? -16.293 -58.134 -23.388 1.00 20.40  ? 766  TYR A C   1 
ATOM   3701 O  O   . TYR A 1 503 ? -15.706 -58.921 -22.611 1.00 18.39  ? 766  TYR A O   1 
ATOM   3702 C  CB  . TYR A 1 503 ? -15.729 -56.153 -21.890 1.00 21.26  ? 766  TYR A CB  1 
ATOM   3703 C  CG  . TYR A 1 503 ? -15.542 -54.665 -21.718 1.00 22.01  ? 766  TYR A CG  1 
ATOM   3704 C  CD1 . TYR A 1 503 ? -14.519 -53.969 -22.358 1.00 21.65  ? 766  TYR A CD1 1 
ATOM   3705 C  CD2 . TYR A 1 503 ? -16.346 -53.942 -20.869 1.00 25.84  ? 766  TYR A CD2 1 
ATOM   3706 C  CE1 . TYR A 1 503 ? -14.352 -52.608 -22.162 1.00 21.09  ? 766  TYR A CE1 1 
ATOM   3707 C  CE2 . TYR A 1 503 ? -16.226 -52.569 -20.699 1.00 25.84  ? 766  TYR A CE2 1 
ATOM   3708 C  CZ  . TYR A 1 503 ? -15.207 -51.894 -21.333 1.00 23.74  ? 766  TYR A CZ  1 
ATOM   3709 O  OH  . TYR A 1 503 ? -15.045 -50.564 -21.080 1.00 22.41  ? 766  TYR A OH  1 
ATOM   3710 N  N   . PHE A 1 504 ? -17.119 -58.543 -24.346 1.00 19.77  ? 767  PHE A N   1 
ATOM   3711 C  CA  . PHE A 1 504 ? -17.507 -59.952 -24.596 1.00 21.61  ? 767  PHE A CA  1 
ATOM   3712 C  C   . PHE A 1 504 ? -16.272 -60.819 -24.869 1.00 21.32  ? 767  PHE A C   1 
ATOM   3713 O  O   . PHE A 1 504 ? -16.342 -62.056 -24.719 1.00 20.58  ? 767  PHE A O   1 
ATOM   3714 C  CB  . PHE A 1 504 ? -18.467 -60.050 -25.791 1.00 21.60  ? 767  PHE A CB  1 
ATOM   3715 C  CG  . PHE A 1 504 ? -17.970 -59.336 -27.015 1.00 21.35  ? 767  PHE A CG  1 
ATOM   3716 C  CD1 . PHE A 1 504 ? -17.143 -59.979 -27.924 1.00 21.19  ? 767  PHE A CD1 1 
ATOM   3717 C  CD2 . PHE A 1 504 ? -18.298 -58.005 -27.226 1.00 22.03  ? 767  PHE A CD2 1 
ATOM   3718 C  CE1 . PHE A 1 504 ? -16.649 -59.299 -29.009 1.00 20.74  ? 767  PHE A CE1 1 
ATOM   3719 C  CE2 . PHE A 1 504 ? -17.791 -57.339 -28.323 1.00 21.93  ? 767  PHE A CE2 1 
ATOM   3720 C  CZ  . PHE A 1 504 ? -16.995 -57.997 -29.209 1.00 21.34  ? 767  PHE A CZ  1 
ATOM   3721 N  N   . HIS A 1 505 ? -15.207 -60.184 -25.363 1.00 21.11  ? 768  HIS A N   1 
ATOM   3722 C  CA  . HIS A 1 505 ? -13.929 -60.846 -25.747 1.00 20.43  ? 768  HIS A CA  1 
ATOM   3723 C  C   . HIS A 1 505 ? -13.045 -61.202 -24.540 1.00 20.77  ? 768  HIS A C   1 
ATOM   3724 O  O   . HIS A 1 505 ? -12.011 -61.844 -24.756 1.00 19.40  ? 768  HIS A O   1 
ATOM   3725 C  CB  . HIS A 1 505 ? -13.233 -59.981 -26.773 1.00 19.84  ? 768  HIS A CB  1 
ATOM   3726 C  CG  . HIS A 1 505 ? -13.071 -58.578 -26.303 1.00 20.28  ? 768  HIS A CG  1 
ATOM   3727 N  ND1 . HIS A 1 505 ? -12.006 -58.169 -25.559 1.00 18.98  ? 768  HIS A ND1 1 
ATOM   3728 C  CD2 . HIS A 1 505 ? -13.889 -57.513 -26.452 1.00 20.69  ? 768  HIS A CD2 1 
ATOM   3729 C  CE1 . HIS A 1 505 ? -12.161 -56.883 -25.293 1.00 18.24  ? 768  HIS A CE1 1 
ATOM   3730 N  NE2 . HIS A 1 505 ? -13.363 -56.436 -25.822 1.00 20.44  ? 768  HIS A NE2 1 
ATOM   3731 N  N   . ARG A 1 506 ? -13.436 -60.827 -23.313 1.00 17.51  ? 769  ARG A N   1 
ATOM   3732 C  CA  . ARG A 1 506 ? -12.722 -61.145 -22.058 1.00 18.36  ? 769  ARG A CA  1 
ATOM   3733 C  C   . ARG A 1 506 ? -13.479 -62.327 -21.440 1.00 19.59  ? 769  ARG A C   1 
ATOM   3734 O  O   . ARG A 1 506 ? -14.696 -62.138 -21.127 1.00 20.51  ? 769  ARG A O   1 
ATOM   3735 C  CB  . ARG A 1 506 ? -12.677 -59.921 -21.140 1.00 18.44  ? 769  ARG A CB  1 
ATOM   3736 C  CG  . ARG A 1 506 ? -12.220 -58.608 -21.772 1.00 19.15  ? 769  ARG A CG  1 
ATOM   3737 C  CD  . ARG A 1 506 ? -10.859 -58.718 -22.470 1.00 19.03  ? 769  ARG A CD  1 
ATOM   3738 N  NE  . ARG A 1 506 ? -9.906  -59.249 -21.526 1.00 19.93  ? 769  ARG A NE  1 
ATOM   3739 C  CZ  . ARG A 1 506 ? -9.380  -58.616 -20.498 1.00 21.48  ? 769  ARG A CZ  1 
ATOM   3740 N  NH1 . ARG A 1 506 ? -8.646  -59.297 -19.631 1.00 20.26  ? 769  ARG A NH1 1 
ATOM   3741 N  NH2 . ARG A 1 506 ? -9.519  -57.312 -20.334 1.00 20.04  ? 769  ARG A NH2 1 
ATOM   3742 N  N   . ARG A 1 507 ? -12.862 -63.514 -21.393 1.00 20.38  ? 770  ARG A N   1 
ATOM   3743 C  CA  . ARG A 1 507 ? -13.513 -64.744 -20.878 1.00 21.40  ? 770  ARG A CA  1 
ATOM   3744 C  C   . ARG A 1 507 ? -14.200 -64.501 -19.530 1.00 19.93  ? 770  ARG A C   1 
ATOM   3745 O  O   . ARG A 1 507 ? -15.363 -64.926 -19.391 1.00 21.93  ? 770  ARG A O   1 
ATOM   3746 C  CB  . ARG A 1 507 ? -12.510 -65.897 -20.773 1.00 23.15  ? 770  ARG A CB  1 
ATOM   3747 C  CG  . ARG A 1 507 ? -11.996 -66.358 -22.124 1.00 23.12  ? 770  ARG A CG  1 
ATOM   3748 C  CD  . ARG A 1 507 ? -10.778 -67.292 -22.030 1.00 24.74  ? 770  ARG A CD  1 
ATOM   3749 N  NE  . ARG A 1 507 ? -10.434 -67.776 -23.374 1.00 24.90  ? 770  ARG A NE  1 
ATOM   3750 C  CZ  . ARG A 1 507 ? -9.813  -67.030 -24.271 1.00 26.47  ? 770  ARG A CZ  1 
ATOM   3751 N  NH1 . ARG A 1 507 ? -9.375  -65.816 -23.957 1.00 24.26  ? 770  ARG A NH1 1 
ATOM   3752 N  NH2 . ARG A 1 507 ? -9.590  -67.501 -25.480 1.00 26.03  ? 770  ARG A NH2 1 
ATOM   3753 N  N   . ASP A 1 508 ? -13.541 -63.885 -18.559 1.00 19.30  ? 771  ASP A N   1 
ATOM   3754 C  CA  . ASP A 1 508 ? -14.073 -63.750 -17.189 1.00 20.21  ? 771  ASP A CA  1 
ATOM   3755 C  C   . ASP A 1 508 ? -15.317 -62.834 -17.232 1.00 22.39  ? 771  ASP A C   1 
ATOM   3756 O  O   . ASP A 1 508 ? -16.262 -63.070 -16.427 1.00 20.50  ? 771  ASP A O   1 
ATOM   3757 C  CB  . ASP A 1 508 ? -13.057 -63.159 -16.215 1.00 20.02  ? 771  ASP A CB  1 
ATOM   3758 C  CG  . ASP A 1 508 ? -11.825 -64.036 -16.018 1.00 21.63  ? 771  ASP A CG  1 
ATOM   3759 O  OD1 . ASP A 1 508 ? -11.852 -65.202 -16.440 1.00 21.05  ? 771  ASP A OD1 1 
ATOM   3760 O  OD2 . ASP A 1 508 ? -10.839 -63.499 -15.486 1.00 20.39  ? 771  ASP A OD2 1 
ATOM   3761 N  N   . LEU A 1 509 ? -15.308 -61.794 -18.084 1.00 19.51  ? 772  LEU A N   1 
ATOM   3762 C  CA  . LEU A 1 509 ? -16.415 -60.812 -18.055 1.00 20.22  ? 772  LEU A CA  1 
ATOM   3763 C  C   . LEU A 1 509 ? -17.607 -61.420 -18.794 1.00 21.26  ? 772  LEU A C   1 
ATOM   3764 O  O   . LEU A 1 509 ? -18.738 -61.111 -18.423 1.00 20.31  ? 772  LEU A O   1 
ATOM   3765 C  CB  . LEU A 1 509 ? -15.982 -59.479 -18.654 1.00 21.12  ? 772  LEU A CB  1 
ATOM   3766 C  CG  . LEU A 1 509 ? -14.821 -58.773 -17.910 1.00 20.33  ? 772  LEU A CG  1 
ATOM   3767 C  CD1 . LEU A 1 509 ? -14.623 -57.357 -18.470 1.00 22.12  ? 772  LEU A CD1 1 
ATOM   3768 C  CD2 . LEU A 1 509 ? -15.119 -58.698 -16.408 1.00 23.30  ? 772  LEU A CD2 1 
ATOM   3769 N  N   . ARG A 1 510 ? -17.401 -62.231 -19.819 1.00 20.06  ? 773  ARG A N   1 
ATOM   3770 C  CA  . ARG A 1 510 ? -18.584 -62.804 -20.522 1.00 20.77  ? 773  ARG A CA  1 
ATOM   3771 C  C   . ARG A 1 510 ? -19.256 -63.771 -19.542 1.00 22.15  ? 773  ARG A C   1 
ATOM   3772 O  O   . ARG A 1 510 ? -20.500 -63.798 -19.480 1.00 21.26  ? 773  ARG A O   1 
ATOM   3773 C  CB  . ARG A 1 510 ? -18.244 -63.482 -21.829 1.00 20.64  ? 773  ARG A CB  1 
ATOM   3774 C  CG  . ARG A 1 510 ? -19.485 -63.781 -22.679 1.00 24.24  ? 773  ARG A CG  1 
ATOM   3775 C  CD  . ARG A 1 510 ? -19.255 -64.638 -23.885 1.00 23.02  ? 773  ARG A CD  1 
ATOM   3776 N  NE  . ARG A 1 510 ? -18.328 -64.063 -24.847 1.00 22.86  ? 773  ARG A NE  1 
ATOM   3777 C  CZ  . ARG A 1 510 ? -18.115 -64.546 -26.064 1.00 23.24  ? 773  ARG A CZ  1 
ATOM   3778 N  NH1 . ARG A 1 510 ? -18.901 -65.499 -26.571 1.00 24.73  ? 773  ARG A NH1 1 
ATOM   3779 N  NH2 . ARG A 1 510 ? -17.256 -63.943 -26.866 1.00 23.67  ? 773  ARG A NH2 1 
ATOM   3780 N  N   . LEU A 1 511 ? -18.460 -64.541 -18.786 1.00 22.01  ? 774  LEU A N   1 
ATOM   3781 C  CA  . LEU A 1 511 ? -18.998 -65.500 -17.793 1.00 22.33  ? 774  LEU A CA  1 
ATOM   3782 C  C   . LEU A 1 511 ? -19.703 -64.734 -16.669 1.00 20.72  ? 774  LEU A C   1 
ATOM   3783 O  O   . LEU A 1 511 ? -20.856 -65.069 -16.326 1.00 20.18  ? 774  LEU A O   1 
ATOM   3784 C  CB  . LEU A 1 511 ? -17.841 -66.364 -17.242 1.00 23.14  ? 774  LEU A CB  1 
ATOM   3785 C  CG  . LEU A 1 511 ? -18.268 -67.654 -16.545 1.00 24.38  ? 774  LEU A CG  1 
ATOM   3786 C  CD1 . LEU A 1 511 ? -17.107 -68.635 -16.461 1.00 26.29  ? 774  LEU A CD1 1 
ATOM   3787 C  CD2 . LEU A 1 511 ? -18.813 -67.398 -15.148 1.00 24.42  ? 774  LEU A CD2 1 
ATOM   3788 N  N   . ALA A 1 512 ? -19.091 -63.709 -16.108 1.00 19.35  ? 775  ALA A N   1 
ATOM   3789 C  CA  . ALA A 1 512 ? -19.660 -62.970 -14.959 1.00 19.52  ? 775  ALA A CA  1 
ATOM   3790 C  C   . ALA A 1 512 ? -20.929 -62.221 -15.429 1.00 20.88  ? 775  ALA A C   1 
ATOM   3791 O  O   . ALA A 1 512 ? -21.914 -62.171 -14.665 1.00 20.02  ? 775  ALA A O   1 
ATOM   3792 C  CB  . ALA A 1 512 ? -18.661 -62.019 -14.381 1.00 19.57  ? 775  ALA A CB  1 
ATOM   3793 N  N   . ALA A 1 513 ? -20.922 -61.693 -16.646 1.00 20.46  ? 776  ALA A N   1 
ATOM   3794 C  CA  . ALA A 1 513 ? -22.104 -60.989 -17.229 1.00 22.13  ? 776  ALA A CA  1 
ATOM   3795 C  C   . ALA A 1 513 ? -23.278 -61.967 -17.330 1.00 21.48  ? 776  ALA A C   1 
ATOM   3796 O  O   . ALA A 1 513 ? -24.438 -61.601 -16.946 1.00 21.49  ? 776  ALA A O   1 
ATOM   3797 C  CB  . ALA A 1 513 ? -21.783 -60.380 -18.562 1.00 20.75  ? 776  ALA A CB  1 
ATOM   3798 N  N   . ASN A 1 514 ? -23.002 -63.137 -17.882 1.00 19.52  ? 777  ASN A N   1 
ATOM   3799 C  CA  . ASN A 1 514 ? -24.059 -64.182 -17.993 1.00 23.99  ? 777  ASN A CA  1 
ATOM   3800 C  C   . ASN A 1 514 ? -24.546 -64.568 -16.603 1.00 21.92  ? 777  ASN A C   1 
ATOM   3801 O  O   . ASN A 1 514 ? -25.789 -64.689 -16.434 1.00 22.78  ? 777  ASN A O   1 
ATOM   3802 C  CB  . ASN A 1 514 ? -23.598 -65.409 -18.753 1.00 25.07  ? 777  ASN A CB  1 
ATOM   3803 C  CG  . ASN A 1 514 ? -23.513 -65.097 -20.228 1.00 27.06  ? 777  ASN A CG  1 
ATOM   3804 O  OD1 . ASN A 1 514 ? -24.349 -64.378 -20.755 1.00 32.78  ? 777  ASN A OD1 1 
ATOM   3805 N  ND2 . ASN A 1 514 ? -22.539 -65.690 -20.878 1.00 29.08  ? 777  ASN A ND2 1 
ATOM   3806 N  N   . ALA A 1 515 ? -23.667 -64.709 -15.610 1.00 21.00  ? 778  ALA A N   1 
ATOM   3807 C  CA  . ALA A 1 515 ? -24.073 -65.060 -14.226 1.00 20.88  ? 778  ALA A CA  1 
ATOM   3808 C  C   . ALA A 1 515 ? -24.970 -63.956 -13.636 1.00 20.28  ? 778  ALA A C   1 
ATOM   3809 O  O   . ALA A 1 515 ? -25.997 -64.280 -13.011 1.00 22.68  ? 778  ALA A O   1 
ATOM   3810 C  CB  . ALA A 1 515 ? -22.862 -65.350 -13.360 1.00 20.06  ? 778  ALA A CB  1 
ATOM   3811 N  N   . ILE A 1 516 ? -24.593 -62.674 -13.754 1.00 19.68  ? 779  ILE A N   1 
ATOM   3812 C  CA  . ILE A 1 516 ? -25.362 -61.548 -13.162 1.00 20.85  ? 779  ILE A CA  1 
ATOM   3813 C  C   . ILE A 1 516 ? -26.739 -61.510 -13.849 1.00 21.64  ? 779  ILE A C   1 
ATOM   3814 O  O   . ILE A 1 516 ? -27.761 -61.406 -13.139 1.00 22.21  ? 779  ILE A O   1 
ATOM   3815 C  CB  . ILE A 1 516 ? -24.648 -60.196 -13.344 1.00 19.07  ? 779  ILE A CB  1 
ATOM   3816 C  CG1 . ILE A 1 516 ? -23.360 -60.169 -12.528 1.00 19.38  ? 779  ILE A CG1 1 
ATOM   3817 C  CG2 . ILE A 1 516 ? -25.561 -59.045 -12.948 1.00 20.32  ? 779  ILE A CG2 1 
ATOM   3818 C  CD1 . ILE A 1 516 ? -22.373 -59.058 -12.921 1.00 20.28  ? 779  ILE A CD1 1 
ATOM   3819 N  N   . CYS A 1 517 ? -26.763 -61.660 -15.164 1.00 21.79  ? 780  CYS A N   1 
ATOM   3820 C  CA  . CYS A 1 517 ? -28.053 -61.617 -15.927 1.00 22.71  ? 780  CYS A CA  1 
ATOM   3821 C  C   . CYS A 1 517 ? -28.926 -62.813 -15.531 1.00 25.59  ? 780  CYS A C   1 
ATOM   3822 O  O   . CYS A 1 517 ? -30.186 -62.716 -15.683 1.00 25.20  ? 780  CYS A O   1 
ATOM   3823 C  CB  . CYS A 1 517 ? -27.819 -61.506 -17.425 1.00 24.55  ? 780  CYS A CB  1 
ATOM   3824 S  SG  . CYS A 1 517 ? -27.229 -59.845 -17.873 1.00 28.04  ? 780  CYS A SG  1 
ATOM   3825 N  N   . SER A 1 518 ? -28.330 -63.917 -15.111 1.00 22.94  ? 781  SER A N   1 
ATOM   3826 C  CA  . SER A 1 518 ? -29.063 -65.135 -14.664 1.00 23.91  ? 781  SER A CA  1 
ATOM   3827 C  C   . SER A 1 518 ? -29.606 -64.912 -13.255 1.00 25.78  ? 781  SER A C   1 
ATOM   3828 O  O   . SER A 1 518 ? -30.602 -65.571 -12.900 1.00 23.34  ? 781  SER A O   1 
ATOM   3829 C  CB  . SER A 1 518 ? -28.217 -66.398 -14.702 1.00 24.16  ? 781  SER A CB  1 
ATOM   3830 O  OG  . SER A 1 518 ? -27.823 -66.722 -16.016 1.00 26.07  ? 781  SER A OG  1 
ATOM   3831 N  N   . ALA A 1 519 ? -28.938 -64.081 -12.446 1.00 22.21  ? 782  ALA A N   1 
ATOM   3832 C  CA  . ALA A 1 519 ? -29.221 -63.897 -11.005 1.00 22.58  ? 782  ALA A CA  1 
ATOM   3833 C  C   . ALA A 1 519 ? -30.241 -62.798 -10.792 1.00 21.43  ? 782  ALA A C   1 
ATOM   3834 O  O   . ALA A 1 519 ? -30.753 -62.722 -9.683  1.00 25.25  ? 782  ALA A O   1 
ATOM   3835 C  CB  . ALA A 1 519 ? -27.965 -63.652 -10.190 1.00 21.21  ? 782  ALA A CB  1 
ATOM   3836 N  N   . VAL A 1 520 ? -30.421 -61.909 -11.752 1.00 22.43  ? 783  VAL A N   1 
ATOM   3837 C  CA  . VAL A 1 520 ? -31.342 -60.769 -11.613 1.00 22.73  ? 783  VAL A CA  1 
ATOM   3838 C  C   . VAL A 1 520 ? -32.606 -61.121 -12.413 1.00 24.11  ? 783  VAL A C   1 
ATOM   3839 O  O   . VAL A 1 520 ? -32.531 -61.661 -13.535 1.00 22.97  ? 783  VAL A O   1 
ATOM   3840 C  CB  . VAL A 1 520 ? -30.663 -59.493 -12.134 1.00 25.29  ? 783  VAL A CB  1 
ATOM   3841 C  CG1 . VAL A 1 520 ? -31.637 -58.330 -12.159 1.00 23.68  ? 783  VAL A CG1 1 
ATOM   3842 C  CG2 . VAL A 1 520 ? -29.420 -59.134 -11.304 1.00 22.42  ? 783  VAL A CG2 1 
ATOM   3843 N  N   . PRO A 1 521 ? -33.828 -60.888 -11.860 1.00 23.12  ? 784  PRO A N   1 
ATOM   3844 C  CA  . PRO A 1 521 ? -35.028 -61.229 -12.599 1.00 24.44  ? 784  PRO A CA  1 
ATOM   3845 C  C   . PRO A 1 521 ? -34.994 -60.700 -14.027 1.00 24.96  ? 784  PRO A C   1 
ATOM   3846 O  O   . PRO A 1 521 ? -34.641 -59.530 -14.261 1.00 24.74  ? 784  PRO A O   1 
ATOM   3847 C  CB  . PRO A 1 521 ? -36.158 -60.572 -11.740 1.00 22.56  ? 784  PRO A CB  1 
ATOM   3848 C  CG  . PRO A 1 521 ? -35.626 -60.693 -10.329 1.00 24.75  ? 784  PRO A CG  1 
ATOM   3849 C  CD  . PRO A 1 521 ? -34.137 -60.369 -10.523 1.00 23.59  ? 784  PRO A CD  1 
ATOM   3850 N  N   A SER A 1 522 ? -35.408 -61.535 -14.980 0.25 26.85  ? 785  SER A N   1 
ATOM   3851 N  N   B SER A 1 522 ? -35.434 -61.553 -14.960 0.25 26.51  ? 785  SER A N   1 
ATOM   3852 C  CA  A SER A 1 522 ? -35.198 -61.298 -16.433 0.25 29.14  ? 785  SER A CA  1 
ATOM   3853 C  CA  B SER A 1 522 ? -35.304 -61.370 -16.431 0.25 28.90  ? 785  SER A CA  1 
ATOM   3854 C  C   A SER A 1 522 ? -35.867 -59.996 -16.891 0.25 29.03  ? 785  SER A C   1 
ATOM   3855 C  C   B SER A 1 522 ? -35.867 -60.015 -16.866 0.25 28.86  ? 785  SER A C   1 
ATOM   3856 O  O   A SER A 1 522 ? -35.297 -59.338 -17.781 0.25 26.56  ? 785  SER A O   1 
ATOM   3857 O  O   B SER A 1 522 ? -35.232 -59.362 -17.710 0.25 26.84  ? 785  SER A O   1 
ATOM   3858 C  CB  A SER A 1 522 ? -35.681 -62.478 -17.238 0.25 32.17  ? 785  SER A CB  1 
ATOM   3859 C  CB  B SER A 1 522 ? -35.990 -62.493 -17.187 0.25 31.36  ? 785  SER A CB  1 
ATOM   3860 O  OG  A SER A 1 522 ? -37.087 -62.609 -17.120 0.25 33.95  ? 785  SER A OG  1 
ATOM   3861 O  OG  B SER A 1 522 ? -36.010 -63.691 -16.427 0.25 32.06  ? 785  SER A OG  1 
ATOM   3862 N  N   . HIS A 1 523 ? -37.028 -59.616 -16.326 1.00 28.61  ? 786  HIS A N   1 
ATOM   3863 C  CA  . HIS A 1 523 ? -37.759 -58.397 -16.788 1.00 27.08  ? 786  HIS A CA  1 
ATOM   3864 C  C   . HIS A 1 523 ? -37.385 -57.137 -16.032 1.00 27.06  ? 786  HIS A C   1 
ATOM   3865 O  O   . HIS A 1 523 ? -37.825 -56.054 -16.447 1.00 28.86  ? 786  HIS A O   1 
ATOM   3866 C  CB  . HIS A 1 523 ? -39.283 -58.637 -16.799 1.00 29.33  ? 786  HIS A CB  1 
ATOM   3867 C  CG  . HIS A 1 523 ? -39.678 -59.756 -17.702 1.00 28.91  ? 786  HIS A CG  1 
ATOM   3868 N  ND1 . HIS A 1 523 ? -39.805 -59.584 -19.072 1.00 34.43  ? 786  HIS A ND1 1 
ATOM   3869 C  CD2 . HIS A 1 523 ? -39.921 -61.061 -17.455 1.00 36.31  ? 786  HIS A CD2 1 
ATOM   3870 C  CE1 . HIS A 1 523 ? -40.131 -60.740 -19.630 1.00 36.90  ? 786  HIS A CE1 1 
ATOM   3871 N  NE2 . HIS A 1 523 ? -40.242 -61.673 -18.656 1.00 34.15  ? 786  HIS A NE2 1 
ATOM   3872 N  N   . TRP A 1 524 ? -36.533 -57.202 -15.007 1.00 26.48  ? 787  TRP A N   1 
ATOM   3873 C  CA  . TRP A 1 524 ? -36.144 -55.981 -14.263 1.00 24.61  ? 787  TRP A CA  1 
ATOM   3874 C  C   . TRP A 1 524 ? -35.261 -55.103 -15.150 1.00 25.95  ? 787  TRP A C   1 
ATOM   3875 O  O   . TRP A 1 524 ? -34.400 -55.634 -15.854 1.00 29.06  ? 787  TRP A O   1 
ATOM   3876 C  CB  . TRP A 1 524 ? -35.513 -56.343 -12.901 1.00 24.96  ? 787  TRP A CB  1 
ATOM   3877 C  CG  . TRP A 1 524 ? -36.512 -56.810 -11.874 1.00 25.91  ? 787  TRP A CG  1 
ATOM   3878 C  CD1 . TRP A 1 524 ? -37.833 -57.153 -12.060 1.00 26.45  ? 787  TRP A CD1 1 
ATOM   3879 C  CD2 . TRP A 1 524 ? -36.237 -57.052 -10.487 1.00 26.56  ? 787  TRP A CD2 1 
ATOM   3880 N  NE1 . TRP A 1 524 ? -38.390 -57.596 -10.882 1.00 25.96  ? 787  TRP A NE1 1 
ATOM   3881 C  CE2 . TRP A 1 524 ? -37.440 -57.505 -9.884  1.00 26.92  ? 787  TRP A CE2 1 
ATOM   3882 C  CE3 . TRP A 1 524 ? -35.069 -56.974 -9.716  1.00 27.89  ? 787  TRP A CE3 1 
ATOM   3883 C  CZ2 . TRP A 1 524 ? -37.504 -57.849 -8.533  1.00 28.56  ? 787  TRP A CZ2 1 
ATOM   3884 C  CZ3 . TRP A 1 524 ? -35.158 -57.304 -8.374  1.00 29.58  ? 787  TRP A CZ3 1 
ATOM   3885 C  CH2 . TRP A 1 524 ? -36.350 -57.700 -7.786  1.00 26.29  ? 787  TRP A CH2 1 
ATOM   3886 N  N   . VAL A 1 525 ? -35.502 -53.799 -15.120 1.00 26.21  ? 788  VAL A N   1 
ATOM   3887 C  CA  . VAL A 1 525 ? -34.897 -52.849 -16.090 1.00 28.48  ? 788  VAL A CA  1 
ATOM   3888 C  C   . VAL A 1 525 ? -33.565 -52.349 -15.542 1.00 27.38  ? 788  VAL A C   1 
ATOM   3889 O  O   . VAL A 1 525 ? -33.481 -51.772 -14.459 1.00 28.23  ? 788  VAL A O   1 
ATOM   3890 C  CB  . VAL A 1 525 ? -35.849 -51.662 -16.331 1.00 31.43  ? 788  VAL A CB  1 
ATOM   3891 C  CG1 . VAL A 1 525 ? -35.240 -50.614 -17.261 1.00 32.23  ? 788  VAL A CG1 1 
ATOM   3892 C  CG2 . VAL A 1 525 ? -37.218 -52.132 -16.816 1.00 33.33  ? 788  VAL A CG2 1 
ATOM   3893 N  N   . PRO A 1 526 ? -32.475 -52.444 -16.315 1.00 29.73  ? 789  PRO A N   1 
ATOM   3894 C  CA  . PRO A 1 526 ? -31.218 -51.857 -15.885 1.00 29.43  ? 789  PRO A CA  1 
ATOM   3895 C  C   . PRO A 1 526 ? -31.319 -50.371 -15.572 1.00 31.81  ? 789  PRO A C   1 
ATOM   3896 O  O   . PRO A 1 526 ? -31.988 -49.654 -16.330 1.00 29.81  ? 789  PRO A O   1 
ATOM   3897 C  CB  . PRO A 1 526 ? -30.281 -52.017 -17.077 1.00 28.52  ? 789  PRO A CB  1 
ATOM   3898 C  CG  . PRO A 1 526 ? -30.938 -52.947 -18.028 1.00 30.12  ? 789  PRO A CG  1 
ATOM   3899 C  CD  . PRO A 1 526 ? -32.391 -53.072 -17.636 1.00 29.17  ? 789  PRO A CD  1 
ATOM   3900 N  N   . THR A 1 527 ? -30.617 -49.927 -14.524 1.00 34.39  ? 790  THR A N   1 
ATOM   3901 C  CA  . THR A 1 527 ? -30.622 -48.513 -14.074 1.00 41.36  ? 790  THR A CA  1 
ATOM   3902 C  C   . THR A 1 527 ? -29.222 -48.012 -13.794 1.00 46.78  ? 790  THR A C   1 
ATOM   3903 O  O   . THR A 1 527 ? -28.273 -48.829 -13.674 1.00 43.48  ? 790  THR A O   1 
ATOM   3904 C  CB  . THR A 1 527 ? -31.376 -48.259 -12.753 1.00 54.37  ? 790  THR A CB  1 
ATOM   3905 O  OG1 . THR A 1 527 ? -30.844 -49.060 -11.681 1.00 61.58  ? 790  THR A OG1 1 
ATOM   3906 C  CG2 . THR A 1 527 ? -32.858 -48.465 -12.923 1.00 60.98  ? 790  THR A CG2 1 
ATOM   3907 N  N   . SER A 1 528 ? -29.097 -46.691 -13.714 0.50 44.43  ? 791  SER A N   1 
ATOM   3908 C  CA  . SER A 1 528 ? -27.887 -45.954 -13.274 0.50 48.89  ? 791  SER A CA  1 
ATOM   3909 C  C   . SER A 1 528 ? -28.312 -44.531 -12.897 0.50 51.38  ? 791  SER A C   1 
ATOM   3910 O  O   . SER A 1 528 ? -28.857 -43.833 -13.781 0.50 51.07  ? 791  SER A O   1 
ATOM   3911 C  CB  . SER A 1 528 ? -26.829 -45.960 -14.349 0.50 48.26  ? 791  SER A CB  1 
ATOM   3912 O  OG  . SER A 1 528 ? -25.543 -45.713 -13.794 0.50 49.49  ? 791  SER A OG  1 
ATOM   3913 N  N   . ARG A 1 529 ? -28.126 -44.143 -11.631 0.50 53.59  ? 792  ARG A N   1 
ATOM   3914 C  CA  . ARG A 1 529 ? -28.325 -42.748 -11.147 0.50 56.34  ? 792  ARG A CA  1 
ATOM   3915 C  C   . ARG A 1 529 ? -27.279 -41.841 -11.808 0.50 62.34  ? 792  ARG A C   1 
ATOM   3916 O  O   . ARG A 1 529 ? -27.596 -40.659 -12.067 0.50 63.23  ? 792  ARG A O   1 
ATOM   3917 C  CB  . ARG A 1 529 ? -28.188 -42.661 -9.624  0.50 53.60  ? 792  ARG A CB  1 
ATOM   3918 C  CG  . ARG A 1 529 ? -29.286 -43.365 -8.841  0.50 51.54  ? 792  ARG A CG  1 
ATOM   3919 C  CD  . ARG A 1 529 ? -29.203 -43.045 -7.356  0.50 49.82  ? 792  ARG A CD  1 
ATOM   3920 N  NE  . ARG A 1 529 ? -29.859 -44.046 -6.524  0.50 49.99  ? 792  ARG A NE  1 
ATOM   3921 C  CZ  . ARG A 1 529 ? -29.778 -44.096 -5.199  0.50 46.29  ? 792  ARG A CZ  1 
ATOM   3922 N  NH1 . ARG A 1 529 ? -29.074 -43.184 -4.551  0.50 44.33  ? 792  ARG A NH1 1 
ATOM   3923 N  NH2 . ARG A 1 529 ? -30.406 -45.049 -4.530  0.50 42.92  ? 792  ARG A NH2 1 
ATOM   3924 N  N   . THR A 1 530 ? -26.081 -42.386 -12.054 0.50 65.55  ? 793  THR A N   1 
ATOM   3925 C  CA  . THR A 1 530 ? -24.885 -41.668 -12.574 0.50 69.52  ? 793  THR A CA  1 
ATOM   3926 C  C   . THR A 1 530 ? -24.804 -41.828 -14.099 0.50 69.44  ? 793  THR A C   1 
ATOM   3927 O  O   . THR A 1 530 ? -24.399 -42.922 -14.543 0.50 68.16  ? 793  THR A O   1 
ATOM   3928 C  CB  . THR A 1 530 ? -23.614 -42.164 -11.871 0.50 69.12  ? 793  THR A CB  1 
ATOM   3929 O  OG1 . THR A 1 530 ? -23.591 -43.590 -11.943 0.50 67.63  ? 793  THR A OG1 1 
ATOM   3930 C  CG2 . THR A 1 530 ? -23.538 -41.727 -10.425 0.50 70.35  ? 793  THR A CG2 1 
ATOM   3931 N  N   . ALA A 1 536 ? -20.131 -41.431 -24.693 0.50 89.96  ? 799  ALA A N   1 
ATOM   3932 C  CA  . ALA A 1 536 ? -20.446 -42.875 -24.807 0.50 87.16  ? 799  ALA A CA  1 
ATOM   3933 C  C   . ALA A 1 536 ? -21.956 -43.066 -25.001 0.50 84.99  ? 799  ALA A C   1 
ATOM   3934 O  O   . ALA A 1 536 ? -22.735 -42.550 -24.169 0.50 88.12  ? 799  ALA A O   1 
ATOM   3935 C  CB  . ALA A 1 536 ? -19.949 -43.605 -23.581 0.50 86.89  ? 799  ALA A CB  1 
ATOM   3936 N  N   . THR A 1 537 ? -22.350 -43.777 -26.065 0.50 77.19  ? 800  THR A N   1 
ATOM   3937 C  CA  . THR A 1 537 ? -23.757 -44.163 -26.364 0.50 67.82  ? 800  THR A CA  1 
ATOM   3938 C  C   . THR A 1 537 ? -24.059 -45.488 -25.660 0.50 61.66  ? 800  THR A C   1 
ATOM   3939 O  O   . THR A 1 537 ? -23.337 -46.480 -25.926 0.50 61.18  ? 800  THR A O   1 
ATOM   3940 C  CB  . THR A 1 537 ? -24.002 -44.254 -27.874 0.50 69.58  ? 800  THR A CB  1 
ATOM   3941 O  OG1 . THR A 1 537 ? -23.379 -45.443 -28.361 0.50 69.65  ? 800  THR A OG1 1 
ATOM   3942 C  CG2 . THR A 1 537 ? -23.476 -43.051 -28.625 0.50 69.17  ? 800  THR A CG2 1 
ATOM   3943 N  N   A HIS A 1 538 ? -25.086 -45.504 -24.805 0.25 51.70  ? 801  HIS A N   1 
ATOM   3944 N  N   B HIS A 1 538 ? -25.123 -45.482 -24.825 0.25 53.18  ? 801  HIS A N   1 
ATOM   3945 C  CA  A HIS A 1 538 ? -25.311 -46.571 -23.793 0.25 45.36  ? 801  HIS A CA  1 
ATOM   3946 C  CA  B HIS A 1 538 ? -25.412 -46.514 -23.791 0.25 47.42  ? 801  HIS A CA  1 
ATOM   3947 C  C   A HIS A 1 538 ? -26.328 -47.589 -24.325 0.25 38.55  ? 801  HIS A C   1 
ATOM   3948 C  C   B HIS A 1 538 ? -26.364 -47.582 -24.343 0.25 39.50  ? 801  HIS A C   1 
ATOM   3949 O  O   A HIS A 1 538 ? -27.416 -47.716 -23.741 0.25 35.44  ? 801  HIS A O   1 
ATOM   3950 O  O   B HIS A 1 538 ? -27.460 -47.742 -23.780 0.25 36.10  ? 801  HIS A O   1 
ATOM   3951 C  CB  A HIS A 1 538 ? -25.679 -45.929 -22.451 0.25 46.51  ? 801  HIS A CB  1 
ATOM   3952 C  CB  B HIS A 1 538 ? -25.974 -45.841 -22.531 0.25 50.09  ? 801  HIS A CB  1 
ATOM   3953 C  CG  A HIS A 1 538 ? -24.529 -45.222 -21.816 0.25 45.06  ? 801  HIS A CG  1 
ATOM   3954 C  CG  B HIS A 1 538 ? -26.706 -44.572 -22.809 0.25 49.89  ? 801  HIS A CG  1 
ATOM   3955 N  ND1 A HIS A 1 538 ? -24.376 -45.137 -20.449 0.25 46.46  ? 801  HIS A ND1 1 
ATOM   3956 N  ND1 B HIS A 1 538 ? -26.633 -43.480 -21.968 0.25 52.22  ? 801  HIS A ND1 1 
ATOM   3957 C  CD2 A HIS A 1 538 ? -23.461 -44.599 -22.358 0.25 46.47  ? 801  HIS A CD2 1 
ATOM   3958 C  CD2 B HIS A 1 538 ? -27.490 -44.205 -23.844 0.25 51.90  ? 801  HIS A CD2 1 
ATOM   3959 C  CE1 A HIS A 1 538 ? -23.272 -44.471 -20.174 0.25 47.18  ? 801  HIS A CE1 1 
ATOM   3960 C  CE1 B HIS A 1 538 ? -27.361 -42.500 -22.464 0.25 52.89  ? 801  HIS A CE1 1 
ATOM   3961 N  NE2 A HIS A 1 538 ? -22.691 -44.133 -21.329 0.25 44.93  ? 801  HIS A NE2 1 
ATOM   3962 N  NE2 B HIS A 1 538 ? -27.899 -42.919 -23.615 0.25 52.24  ? 801  HIS A NE2 1 
ATOM   3963 N  N   . GLU A 1 539 ? -25.944 -48.325 -25.368 1.00 35.67  ? 802  GLU A N   1 
ATOM   3964 C  CA  . GLU A 1 539 ? -26.813 -49.352 -26.012 1.00 36.30  ? 802  GLU A CA  1 
ATOM   3965 C  C   . GLU A 1 539 ? -27.164 -50.505 -25.073 1.00 35.94  ? 802  GLU A C   1 
ATOM   3966 O  O   . GLU A 1 539 ? -28.153 -51.207 -25.385 1.00 31.52  ? 802  GLU A O   1 
ATOM   3967 C  CB  . GLU A 1 539 ? -26.195 -49.937 -27.270 1.00 45.47  ? 802  GLU A CB  1 
ATOM   3968 C  CG  . GLU A 1 539 ? -26.455 -49.078 -28.484 1.00 52.70  ? 802  GLU A CG  1 
ATOM   3969 C  CD  . GLU A 1 539 ? -25.320 -48.103 -28.633 1.00 59.51  ? 802  GLU A CD  1 
ATOM   3970 O  OE1 . GLU A 1 539 ? -25.264 -47.437 -29.695 1.00 71.48  ? 802  GLU A OE1 1 
ATOM   3971 O  OE2 . GLU A 1 539 ? -24.472 -48.058 -27.691 1.00 62.93  ? 802  GLU A OE2 1 
ATOM   3972 N  N   . TRP A 1 540 ? -26.413 -50.709 -23.970 1.00 27.30  ? 803  TRP A N   1 
ATOM   3973 C  CA  . TRP A 1 540 ? -26.685 -51.808 -23.015 1.00 27.71  ? 803  TRP A CA  1 
ATOM   3974 C  C   . TRP A 1 540 ? -27.849 -51.428 -22.087 1.00 31.42  ? 803  TRP A C   1 
ATOM   3975 O  O   . TRP A 1 540 ? -28.286 -52.255 -21.307 1.00 28.44  ? 803  TRP A O   1 
ATOM   3976 C  CB  . TRP A 1 540 ? -25.381 -52.154 -22.247 1.00 27.41  ? 803  TRP A CB  1 
ATOM   3977 C  CG  . TRP A 1 540 ? -24.778 -51.012 -21.491 1.00 23.88  ? 803  TRP A CG  1 
ATOM   3978 C  CD1 . TRP A 1 540 ? -25.097 -50.590 -20.242 1.00 25.62  ? 803  TRP A CD1 1 
ATOM   3979 C  CD2 . TRP A 1 540 ? -23.775 -50.093 -21.974 1.00 24.17  ? 803  TRP A CD2 1 
ATOM   3980 N  NE1 . TRP A 1 540 ? -24.368 -49.472 -19.910 1.00 28.08  ? 803  TRP A NE1 1 
ATOM   3981 C  CE2 . TRP A 1 540 ? -23.516 -49.172 -20.937 1.00 27.58  ? 803  TRP A CE2 1 
ATOM   3982 C  CE3 . TRP A 1 540 ? -23.022 -50.008 -23.144 1.00 26.98  ? 803  TRP A CE3 1 
ATOM   3983 C  CZ2 . TRP A 1 540 ? -22.600 -48.133 -21.079 1.00 30.81  ? 803  TRP A CZ2 1 
ATOM   3984 C  CZ3 . TRP A 1 540 ? -22.053 -49.030 -23.251 1.00 31.15  ? 803  TRP A CZ3 1 
ATOM   3985 C  CH2 . TRP A 1 540 ? -21.846 -48.110 -22.234 1.00 29.83  ? 803  TRP A CH2 1 
ATOM   3986 N  N   . MET A 1 541 ? -28.322 -50.175 -22.092 1.00 30.56  ? 804  MET A N   1 
ATOM   3987 C  CA  . MET A 1 541 ? -29.376 -49.754 -21.136 1.00 28.61  ? 804  MET A CA  1 
ATOM   3988 C  C   . MET A 1 541 ? -30.732 -50.077 -21.791 1.00 37.02  ? 804  MET A C   1 
ATOM   3989 O  O   . MET A 1 541 ? -31.292 -49.187 -22.438 1.00 35.26  ? 804  MET A O   1 
ATOM   3990 C  CB  . MET A 1 541 ? -29.271 -48.278 -20.759 1.00 33.78  ? 804  MET A CB  1 
ATOM   3991 C  CG  . MET A 1 541 ? -27.958 -47.923 -20.029 1.00 35.52  ? 804  MET A CG  1 
ATOM   3992 S  SD  . MET A 1 541 ? -27.835 -48.878 -18.492 1.00 37.50  ? 804  MET A SD  1 
ATOM   3993 C  CE  . MET A 1 541 ? -29.023 -48.014 -17.471 1.00 38.23  ? 804  MET A CE  1 
ATOM   3994 N  N   . THR A 1 542 ? -31.212 -51.318 -21.661 1.00 33.15  ? 805  THR A N   1 
ATOM   3995 C  CA  . THR A 1 542 ? -32.362 -51.858 -22.450 1.00 34.76  ? 805  THR A CA  1 
ATOM   3996 C  C   . THR A 1 542 ? -32.788 -53.202 -21.874 1.00 32.91  ? 805  THR A C   1 
ATOM   3997 O  O   . THR A 1 542 ? -31.927 -53.861 -21.245 1.00 27.54  ? 805  THR A O   1 
ATOM   3998 C  CB  . THR A 1 542 ? -31.983 -52.037 -23.926 1.00 39.35  ? 805  THR A CB  1 
ATOM   3999 O  OG1 . THR A 1 542 ? -33.060 -52.599 -24.687 1.00 42.72  ? 805  THR A OG1 1 
ATOM   4000 C  CG2 . THR A 1 542 ? -30.790 -52.948 -24.090 1.00 43.93  ? 805  THR A CG2 1 
ATOM   4001 N  N   . THR A 1 543 ? -34.040 -53.648 -22.088 1.00 28.95  ? 806  THR A N   1 
ATOM   4002 C  CA  . THR A 1 543 ? -34.459 -55.038 -21.757 1.00 31.08  ? 806  THR A CA  1 
ATOM   4003 C  C   . THR A 1 543 ? -34.534 -55.918 -23.024 1.00 33.45  ? 806  THR A C   1 
ATOM   4004 O  O   . THR A 1 543 ? -34.861 -57.079 -22.876 1.00 32.94  ? 806  THR A O   1 
ATOM   4005 C  CB  . THR A 1 543 ? -35.794 -55.018 -20.987 1.00 43.07  ? 806  THR A CB  1 
ATOM   4006 O  OG1 . THR A 1 543 ? -36.682 -54.275 -21.819 1.00 39.72  ? 806  THR A OG1 1 
ATOM   4007 C  CG2 . THR A 1 543 ? -35.678 -54.328 -19.640 1.00 43.35  ? 806  THR A CG2 1 
ATOM   4008 N  N   . GLU A 1 544 ? -34.144 -55.420 -24.200 1.00 30.29  ? 807  GLU A N   1 
ATOM   4009 C  CA  . GLU A 1 544 ? -33.961 -56.252 -25.412 1.00 31.35  ? 807  GLU A CA  1 
ATOM   4010 C  C   . GLU A 1 544 ? -32.920 -57.358 -25.184 1.00 34.03  ? 807  GLU A C   1 
ATOM   4011 O  O   . GLU A 1 544 ? -32.045 -57.217 -24.323 1.00 30.92  ? 807  GLU A O   1 
ATOM   4012 C  CB  . GLU A 1 544 ? -33.603 -55.344 -26.569 1.00 34.28  ? 807  GLU A CB  1 
ATOM   4013 C  CG  . GLU A 1 544 ? -33.653 -56.047 -27.883 1.00 43.83  ? 807  GLU A CG  1 
ATOM   4014 C  CD  . GLU A 1 544 ? -33.707 -55.073 -29.047 1.00 53.53  ? 807  GLU A CD  1 
ATOM   4015 O  OE1 . GLU A 1 544 ? -34.277 -55.456 -30.106 1.00 60.72  ? 807  GLU A OE1 1 
ATOM   4016 O  OE2 . GLU A 1 544 ? -33.229 -53.921 -28.866 1.00 47.51  ? 807  GLU A OE2 1 
ATOM   4017 N  N   . ASP A 1 545 ? -33.077 -58.474 -25.867 1.00 32.00  ? 808  ASP A N   1 
ATOM   4018 C  CA  . ASP A 1 545 ? -32.144 -59.629 -25.849 1.00 34.74  ? 808  ASP A CA  1 
ATOM   4019 C  C   . ASP A 1 545 ? -30.716 -59.131 -26.218 1.00 29.36  ? 808  ASP A C   1 
ATOM   4020 O  O   . ASP A 1 545 ? -30.585 -58.402 -27.220 1.00 26.10  ? 808  ASP A O   1 
ATOM   4021 C  CB  . ASP A 1 545 ? -32.688 -60.659 -26.823 1.00 39.58  ? 808  ASP A CB  1 
ATOM   4022 C  CG  . ASP A 1 545 ? -31.864 -61.921 -26.985 1.00 49.77  ? 808  ASP A CG  1 
ATOM   4023 O  OD1 . ASP A 1 545 ? -30.654 -61.804 -27.192 1.00 56.68  ? 808  ASP A OD1 1 
ATOM   4024 O  OD2 . ASP A 1 545 ? -32.454 -63.016 -26.936 1.00 64.35  ? 808  ASP A OD2 1 
ATOM   4025 N  N   . MET A 1 546 ? -29.674 -59.448 -25.433 1.00 28.89  ? 809  MET A N   1 
ATOM   4026 C  CA  . MET A 1 546 ? -28.312 -58.851 -25.683 1.00 28.27  ? 809  MET A CA  1 
ATOM   4027 C  C   . MET A 1 546 ? -27.736 -59.391 -26.995 1.00 26.52  ? 809  MET A C   1 
ATOM   4028 O  O   . MET A 1 546 ? -26.940 -58.660 -27.637 1.00 25.82  ? 809  MET A O   1 
ATOM   4029 C  CB  . MET A 1 546 ? -27.356 -59.077 -24.498 1.00 30.07  ? 809  MET A CB  1 
ATOM   4030 C  CG  . MET A 1 546 ? -27.662 -58.096 -23.312 1.00 29.25  ? 809  MET A CG  1 
ATOM   4031 S  SD  . MET A 1 546 ? -27.695 -56.285 -23.724 1.00 39.23  ? 809  MET A SD  1 
ATOM   4032 C  CE  . MET A 1 546 ? -29.389 -55.961 -24.164 1.00 56.94  ? 809  MET A CE  1 
ATOM   4033 N  N   . LEU A 1 547 ? -28.128 -60.581 -27.457 1.00 24.60  ? 810  LEU A N   1 
ATOM   4034 C  CA  . LEU A 1 547 ? -27.617 -61.039 -28.780 1.00 27.04  ? 810  LEU A CA  1 
ATOM   4035 C  C   . LEU A 1 547 ? -28.169 -60.139 -29.892 1.00 27.71  ? 810  LEU A C   1 
ATOM   4036 O  O   . LEU A 1 547 ? -27.407 -59.828 -30.823 1.00 26.43  ? 810  LEU A O   1 
ATOM   4037 C  CB  . LEU A 1 547 ? -27.878 -62.512 -29.069 1.00 30.87  ? 810  LEU A CB  1 
ATOM   4038 C  CG  . LEU A 1 547 ? -27.178 -63.060 -30.322 1.00 29.66  ? 810  LEU A CG  1 
ATOM   4039 C  CD1 . LEU A 1 547 ? -25.650 -63.039 -30.214 1.00 31.97  ? 810  LEU A CD1 1 
ATOM   4040 C  CD2 . LEU A 1 547 ? -27.625 -64.459 -30.609 1.00 33.57  ? 810  LEU A CD2 1 
ATOM   4041 N  N   . THR A 1 548 ? -29.448 -59.758 -29.847 1.00 25.87  ? 811  THR A N   1 
ATOM   4042 C  CA  . THR A 1 548 ? -30.051 -58.853 -30.848 1.00 27.47  ? 811  THR A CA  1 
ATOM   4043 C  C   . THR A 1 548 ? -29.357 -57.477 -30.814 1.00 26.93  ? 811  THR A C   1 
ATOM   4044 O  O   . THR A 1 548 ? -29.069 -56.913 -31.866 1.00 26.86  ? 811  THR A O   1 
ATOM   4045 C  CB  . THR A 1 548 ? -31.560 -58.721 -30.575 1.00 32.70  ? 811  THR A CB  1 
ATOM   4046 O  OG1 . THR A 1 548 ? -32.104 -60.050 -30.625 1.00 31.66  ? 811  THR A OG1 1 
ATOM   4047 C  CG2 . THR A 1 548 ? -32.202 -57.767 -31.552 1.00 31.99  ? 811  THR A CG2 1 
ATOM   4048 N  N   . VAL A 1 549 ? -29.054 -56.962 -29.630 1.00 27.16  ? 812  VAL A N   1 
ATOM   4049 C  CA  . VAL A 1 549 ? -28.332 -55.672 -29.490 1.00 28.32  ? 812  VAL A CA  1 
ATOM   4050 C  C   . VAL A 1 549 ? -26.916 -55.825 -30.053 1.00 25.67  ? 812  VAL A C   1 
ATOM   4051 O  O   . VAL A 1 549 ? -26.459 -54.887 -30.791 1.00 25.71  ? 812  VAL A O   1 
ATOM   4052 C  CB  . VAL A 1 549 ? -28.348 -55.153 -28.046 1.00 27.23  ? 812  VAL A CB  1 
ATOM   4053 C  CG1 . VAL A 1 549 ? -27.585 -53.841 -27.950 1.00 26.45  ? 812  VAL A CG1 1 
ATOM   4054 C  CG2 . VAL A 1 549 ? -29.782 -54.985 -27.553 1.00 31.92  ? 812  VAL A CG2 1 
ATOM   4055 N  N   . TRP A 1 550 ? -26.240 -56.922 -29.735 1.00 27.19  ? 813  TRP A N   1 
ATOM   4056 C  CA  . TRP A 1 550 ? -24.851 -57.150 -30.212 1.00 23.81  ? 813  TRP A CA  1 
ATOM   4057 C  C   . TRP A 1 550 ? -24.872 -57.092 -31.751 1.00 28.04  ? 813  TRP A C   1 
ATOM   4058 O  O   . TRP A 1 550 ? -24.050 -56.381 -32.396 1.00 26.01  ? 813  TRP A O   1 
ATOM   4059 C  CB  . TRP A 1 550 ? -24.295 -58.453 -29.651 1.00 23.77  ? 813  TRP A CB  1 
ATOM   4060 C  CG  . TRP A 1 550 ? -22.839 -58.625 -29.940 1.00 24.90  ? 813  TRP A CG  1 
ATOM   4061 C  CD1 . TRP A 1 550 ? -21.820 -58.389 -29.053 1.00 25.43  ? 813  TRP A CD1 1 
ATOM   4062 C  CD2 . TRP A 1 550 ? -22.210 -59.029 -31.168 1.00 23.93  ? 813  TRP A CD2 1 
ATOM   4063 N  NE1 . TRP A 1 550 ? -20.608 -58.651 -29.615 1.00 24.64  ? 813  TRP A NE1 1 
ATOM   4064 C  CE2 . TRP A 1 550 ? -20.810 -58.998 -30.934 1.00 25.09  ? 813  TRP A CE2 1 
ATOM   4065 C  CE3 . TRP A 1 550 ? -22.668 -59.445 -32.429 1.00 26.04  ? 813  TRP A CE3 1 
ATOM   4066 C  CZ2 . TRP A 1 550 ? -19.887 -59.365 -31.909 1.00 25.13  ? 813  TRP A CZ2 1 
ATOM   4067 C  CZ3 . TRP A 1 550 ? -21.750 -59.789 -33.400 1.00 25.27  ? 813  TRP A CZ3 1 
ATOM   4068 C  CH2 . TRP A 1 550 ? -20.379 -59.747 -33.137 1.00 26.18  ? 813  TRP A CH2 1 
ATOM   4069 N  N   . ASN A 1 551 ? -25.799 -57.828 -32.366 1.00 25.10  ? 814  ASN A N   1 
ATOM   4070 C  CA  . ASN A 1 551 ? -25.942 -57.834 -33.838 1.00 27.59  ? 814  ASN A CA  1 
ATOM   4071 C  C   . ASN A 1 551 ? -26.159 -56.424 -34.380 1.00 25.24  ? 814  ASN A C   1 
ATOM   4072 O  O   . ASN A 1 551 ? -25.548 -56.138 -35.432 1.00 27.25  ? 814  ASN A O   1 
ATOM   4073 C  CB  . ASN A 1 551 ? -27.063 -58.751 -34.344 1.00 29.19  ? 814  ASN A CB  1 
ATOM   4074 C  CG  . ASN A 1 551 ? -26.526 -60.139 -34.542 1.00 33.63  ? 814  ASN A CG  1 
ATOM   4075 O  OD1 . ASN A 1 551 ? -25.625 -60.348 -35.356 1.00 37.91  ? 814  ASN A OD1 1 
ATOM   4076 N  ND2 . ASN A 1 551 ? -27.060 -61.100 -33.812 1.00 37.26  ? 814  ASN A ND2 1 
ATOM   4077 N  N   . ARG A 1 552 ? -27.029 -55.632 -33.765 1.00 25.87  ? 815  ARG A N   1 
ATOM   4078 C  CA  . ARG A 1 552 ? -27.354 -54.302 -34.269 1.00 28.60  ? 815  ARG A CA  1 
ATOM   4079 C  C   . ARG A 1 552 ? -26.080 -53.435 -34.207 1.00 30.42  ? 815  ARG A C   1 
ATOM   4080 O  O   . ARG A 1 552 ? -25.762 -52.743 -35.194 1.00 33.03  ? 815  ARG A O   1 
ATOM   4081 C  CB  . ARG A 1 552 ? -28.531 -53.711 -33.501 1.00 30.85  ? 815  ARG A CB  1 
ATOM   4082 C  CG  . ARG A 1 552 ? -28.967 -52.348 -34.010 1.00 36.42  ? 815  ARG A CG  1 
ATOM   4083 C  CD  . ARG A 1 552 ? -29.984 -51.702 -33.070 1.00 40.72  ? 815  ARG A CD  1 
ATOM   4084 N  NE  . ARG A 1 552 ? -31.136 -52.590 -33.022 1.00 52.72  ? 815  ARG A NE  1 
ATOM   4085 C  CZ  . ARG A 1 552 ? -31.725 -53.102 -31.922 1.00 50.48  ? 815  ARG A CZ  1 
ATOM   4086 N  NH1 . ARG A 1 552 ? -31.315 -52.804 -30.698 1.00 45.90  ? 815  ARG A NH1 1 
ATOM   4087 N  NH2 . ARG A 1 552 ? -32.775 -53.885 -32.081 1.00 53.95  ? 815  ARG A NH2 1 
ATOM   4088 N  N   . VAL A 1 553 ? -25.342 -53.499 -33.103 1.00 27.81  ? 816  VAL A N   1 
ATOM   4089 C  CA  . VAL A 1 553 ? -24.193 -52.582 -32.842 1.00 27.24  ? 816  VAL A CA  1 
ATOM   4090 C  C   . VAL A 1 553 ? -22.972 -53.014 -33.662 1.00 25.12  ? 816  VAL A C   1 
ATOM   4091 O  O   . VAL A 1 553 ? -22.282 -52.142 -34.244 1.00 30.73  ? 816  VAL A O   1 
ATOM   4092 C  CB  . VAL A 1 553 ? -23.922 -52.545 -31.320 1.00 28.33  ? 816  VAL A CB  1 
ATOM   4093 C  CG1 . VAL A 1 553 ? -22.593 -51.889 -31.020 1.00 30.49  ? 816  VAL A CG1 1 
ATOM   4094 C  CG2 . VAL A 1 553 ? -25.059 -51.842 -30.592 1.00 30.34  ? 816  VAL A CG2 1 
ATOM   4095 N  N   . TRP A 1 554 ? -22.605 -54.288 -33.641 1.00 23.72  ? 817  TRP A N   1 
ATOM   4096 C  CA  . TRP A 1 554 ? -21.357 -54.792 -34.214 1.00 22.27  ? 817  TRP A CA  1 
ATOM   4097 C  C   . TRP A 1 554 ? -21.490 -55.189 -35.673 1.00 28.03  ? 817  TRP A C   1 
ATOM   4098 O  O   . TRP A 1 554 ? -20.456 -55.232 -36.315 1.00 26.06  ? 817  TRP A O   1 
ATOM   4099 C  CB  . TRP A 1 554 ? -20.806 -55.945 -33.382 1.00 25.71  ? 817  TRP A CB  1 
ATOM   4100 C  CG  . TRP A 1 554 ? -20.274 -55.453 -32.063 1.00 24.27  ? 817  TRP A CG  1 
ATOM   4101 C  CD1 . TRP A 1 554 ? -20.865 -55.600 -30.847 1.00 24.87  ? 817  TRP A CD1 1 
ATOM   4102 C  CD2 . TRP A 1 554 ? -19.043 -54.718 -31.834 1.00 22.38  ? 817  TRP A CD2 1 
ATOM   4103 N  NE1 . TRP A 1 554 ? -20.107 -55.016 -29.868 1.00 24.67  ? 817  TRP A NE1 1 
ATOM   4104 C  CE2 . TRP A 1 554 ? -18.965 -54.491 -30.438 1.00 22.05  ? 817  TRP A CE2 1 
ATOM   4105 C  CE3 . TRP A 1 554 ? -18.004 -54.281 -32.650 1.00 22.54  ? 817  TRP A CE3 1 
ATOM   4106 C  CZ2 . TRP A 1 554 ? -17.899 -53.815 -29.843 1.00 22.09  ? 817  TRP A CZ2 1 
ATOM   4107 C  CZ3 . TRP A 1 554 ? -16.923 -53.618 -32.059 1.00 22.93  ? 817  TRP A CZ3 1 
ATOM   4108 C  CH2 . TRP A 1 554 ? -16.896 -53.372 -30.687 1.00 19.74  ? 817  TRP A CH2 1 
ATOM   4109 N  N   . ILE A 1 555 ? -22.709 -55.449 -36.177 1.00 27.97  ? 818  ILE A N   1 
ATOM   4110 C  CA  . ILE A 1 555 ? -22.895 -55.900 -37.587 1.00 29.90  ? 818  ILE A CA  1 
ATOM   4111 C  C   . ILE A 1 555 ? -23.761 -54.883 -38.326 1.00 30.05  ? 818  ILE A C   1 
ATOM   4112 O  O   . ILE A 1 555 ? -23.207 -54.167 -39.168 1.00 29.54  ? 818  ILE A O   1 
ATOM   4113 C  CB  . ILE A 1 555 ? -23.499 -57.318 -37.686 1.00 31.65  ? 818  ILE A CB  1 
ATOM   4114 C  CG1 . ILE A 1 555 ? -22.760 -58.353 -36.845 1.00 29.08  ? 818  ILE A CG1 1 
ATOM   4115 C  CG2 . ILE A 1 555 ? -23.573 -57.762 -39.149 1.00 31.54  ? 818  ILE A CG2 1 
ATOM   4116 C  CD1 . ILE A 1 555 ? -21.338 -58.484 -37.186 1.00 30.86  ? 818  ILE A CD1 1 
ATOM   4117 N  N   . GLN A 1 556 ? -25.054 -54.769 -37.997 1.00 34.50  ? 819  GLN A N   1 
ATOM   4118 C  CA  . GLN A 1 556 ? -26.037 -54.036 -38.862 1.00 35.10  ? 819  GLN A CA  1 
ATOM   4119 C  C   . GLN A 1 556 ? -25.603 -52.569 -38.994 1.00 36.26  ? 819  GLN A C   1 
ATOM   4120 O  O   . GLN A 1 556 ? -25.516 -52.087 -40.131 1.00 35.30  ? 819  GLN A O   1 
ATOM   4121 C  CB  . GLN A 1 556 ? -27.454 -54.205 -38.304 1.00 37.98  ? 819  GLN A CB  1 
ATOM   4122 C  CG  . GLN A 1 556 ? -28.531 -53.387 -39.018 1.00 47.18  ? 819  GLN A CG  1 
ATOM   4123 C  CD  . GLN A 1 556 ? -29.781 -53.265 -38.173 1.00 54.00  ? 819  GLN A CD  1 
ATOM   4124 O  OE1 . GLN A 1 556 ? -30.357 -52.183 -38.009 1.00 62.47  ? 819  GLN A OE1 1 
ATOM   4125 N  NE2 . GLN A 1 556 ? -30.181 -54.371 -37.567 1.00 53.72  ? 819  GLN A NE2 1 
ATOM   4126 N  N   . GLU A 1 557 ? -25.301 -51.881 -37.887 1.00 30.65  ? 820  GLU A N   1 
ATOM   4127 C  CA  . GLU A 1 557 ? -25.066 -50.423 -37.858 1.00 31.64  ? 820  GLU A CA  1 
ATOM   4128 C  C   . GLU A 1 557 ? -23.564 -50.093 -37.942 1.00 33.39  ? 820  GLU A C   1 
ATOM   4129 O  O   . GLU A 1 557 ? -23.224 -48.909 -37.864 1.00 36.28  ? 820  GLU A O   1 
ATOM   4130 C  CB  . GLU A 1 557 ? -25.685 -49.783 -36.618 1.00 34.08  ? 820  GLU A CB  1 
ATOM   4131 C  CG  . GLU A 1 557 ? -27.203 -49.964 -36.536 1.00 43.30  ? 820  GLU A CG  1 
ATOM   4132 C  CD  . GLU A 1 557 ? -27.921 -49.219 -35.400 1.00 56.83  ? 820  GLU A CD  1 
ATOM   4133 O  OE1 . GLU A 1 557 ? -27.249 -48.832 -34.386 1.00 61.00  ? 820  GLU A OE1 1 
ATOM   4134 O  OE2 . GLU A 1 557 ? -29.179 -49.039 -35.504 1.00 69.34  ? 820  GLU A OE2 1 
ATOM   4135 N  N   . ASN A 1 558 ? -22.698 -51.086 -38.083 1.00 30.12  ? 821  ASN A N   1 
ATOM   4136 C  CA  . ASN A 1 558 ? -21.217 -50.874 -38.075 1.00 30.17  ? 821  ASN A CA  1 
ATOM   4137 C  C   . ASN A 1 558 ? -20.740 -50.507 -39.483 1.00 29.42  ? 821  ASN A C   1 
ATOM   4138 O  O   . ASN A 1 558 ? -20.631 -51.364 -40.356 1.00 30.77  ? 821  ASN A O   1 
ATOM   4139 C  CB  . ASN A 1 558 ? -20.561 -52.139 -37.550 1.00 28.75  ? 821  ASN A CB  1 
ATOM   4140 C  CG  . ASN A 1 558 ? -19.056 -52.100 -37.456 1.00 27.41  ? 821  ASN A CG  1 
ATOM   4141 O  OD1 . ASN A 1 558 ? -18.431 -51.135 -37.904 1.00 28.60  ? 821  ASN A OD1 1 
ATOM   4142 N  ND2 . ASN A 1 558 ? -18.490 -53.179 -36.913 1.00 25.30  ? 821  ASN A ND2 1 
ATOM   4143 N  N   . PRO A 1 559 ? -20.358 -49.245 -39.746 1.00 31.69  ? 822  PRO A N   1 
ATOM   4144 C  CA  . PRO A 1 559 ? -19.976 -48.842 -41.101 1.00 33.56  ? 822  PRO A CA  1 
ATOM   4145 C  C   . PRO A 1 559 ? -18.680 -49.492 -41.568 1.00 33.39  ? 822  PRO A C   1 
ATOM   4146 O  O   . PRO A 1 559 ? -18.384 -49.441 -42.725 1.00 34.67  ? 822  PRO A O   1 
ATOM   4147 C  CB  . PRO A 1 559 ? -19.834 -47.322 -41.024 1.00 35.72  ? 822  PRO A CB  1 
ATOM   4148 C  CG  . PRO A 1 559 ? -19.584 -47.045 -39.573 1.00 36.11  ? 822  PRO A CG  1 
ATOM   4149 C  CD  . PRO A 1 559 ? -20.344 -48.116 -38.805 1.00 34.90  ? 822  PRO A CD  1 
ATOM   4150 N  N   . TRP A 1 560 ? -17.901 -50.081 -40.666 1.00 32.24  ? 823  TRP A N   1 
ATOM   4151 C  CA  . TRP A 1 560 ? -16.666 -50.783 -41.076 1.00 32.00  ? 823  TRP A CA  1 
ATOM   4152 C  C   . TRP A 1 560 ? -16.881 -52.265 -41.447 1.00 34.43  ? 823  TRP A C   1 
ATOM   4153 O  O   . TRP A 1 560 ? -15.911 -52.831 -41.925 1.00 40.11  ? 823  TRP A O   1 
ATOM   4154 C  CB  . TRP A 1 560 ? -15.595 -50.597 -39.982 1.00 30.54  ? 823  TRP A CB  1 
ATOM   4155 C  CG  . TRP A 1 560 ? -15.143 -49.174 -39.844 1.00 29.29  ? 823  TRP A CG  1 
ATOM   4156 C  CD1 . TRP A 1 560 ? -14.209 -48.531 -40.600 1.00 29.22  ? 823  TRP A CD1 1 
ATOM   4157 C  CD2 . TRP A 1 560 ? -15.655 -48.206 -38.910 1.00 28.96  ? 823  TRP A CD2 1 
ATOM   4158 N  NE1 . TRP A 1 560 ? -14.073 -47.242 -40.161 1.00 30.83  ? 823  TRP A NE1 1 
ATOM   4159 C  CE2 . TRP A 1 560 ? -14.948 -47.009 -39.126 1.00 28.82  ? 823  TRP A CE2 1 
ATOM   4160 C  CE3 . TRP A 1 560 ? -16.585 -48.263 -37.866 1.00 27.89  ? 823  TRP A CE3 1 
ATOM   4161 C  CZ2 . TRP A 1 560 ? -15.158 -45.873 -38.347 1.00 30.72  ? 823  TRP A CZ2 1 
ATOM   4162 C  CZ3 . TRP A 1 560 ? -16.831 -47.128 -37.127 1.00 29.45  ? 823  TRP A CZ3 1 
ATOM   4163 C  CH2 . TRP A 1 560 ? -16.118 -45.945 -37.354 1.00 28.69  ? 823  TRP A CH2 1 
ATOM   4164 N  N   . MET A 1 561 ? -18.085 -52.846 -41.280 1.00 33.57  ? 824  MET A N   1 
ATOM   4165 C  CA  . MET A 1 561 ? -18.427 -54.275 -41.534 1.00 33.82  ? 824  MET A CA  1 
ATOM   4166 C  C   . MET A 1 561 ? -19.238 -54.320 -42.850 1.00 34.27  ? 824  MET A C   1 
ATOM   4167 O  O   . MET A 1 561 ? -20.387 -53.841 -42.868 1.00 33.59  ? 824  MET A O   1 
ATOM   4168 C  CB  . MET A 1 561 ? -19.268 -54.798 -40.352 1.00 36.32  ? 824  MET A CB  1 
ATOM   4169 C  CG  . MET A 1 561 ? -19.480 -56.336 -40.252 1.00 39.71  ? 824  MET A CG  1 
ATOM   4170 S  SD  . MET A 1 561 ? -17.934 -57.169 -40.078 1.00 55.65  ? 824  MET A SD  1 
ATOM   4171 C  CE  . MET A 1 561 ? -17.657 -57.013 -38.309 1.00 48.34  ? 824  MET A CE  1 
ATOM   4172 N  N   . GLU A 1 562 ? -18.668 -54.801 -43.954 1.00 37.81  ? 825  GLU A N   1 
ATOM   4173 C  CA  . GLU A 1 562 ? -19.409 -54.814 -45.252 1.00 46.18  ? 825  GLU A CA  1 
ATOM   4174 C  C   . GLU A 1 562 ? -20.414 -55.980 -45.271 1.00 38.27  ? 825  GLU A C   1 
ATOM   4175 O  O   . GLU A 1 562 ? -21.566 -55.759 -45.679 1.00 40.34  ? 825  GLU A O   1 
ATOM   4176 C  CB  . GLU A 1 562 ? -18.441 -54.891 -46.429 1.00 50.88  ? 825  GLU A CB  1 
ATOM   4177 C  CG  . GLU A 1 562 ? -19.097 -54.591 -47.760 1.00 64.24  ? 825  GLU A CG  1 
ATOM   4178 C  CD  . GLU A 1 562 ? -18.135 -54.555 -48.941 1.00 83.19  ? 825  GLU A CD  1 
ATOM   4179 O  OE1 . GLU A 1 562 ? -18.608 -54.310 -50.079 1.00 95.85  ? 825  GLU A OE1 1 
ATOM   4180 O  OE2 . GLU A 1 562 ? -16.907 -54.751 -48.724 1.00 88.42  ? 825  GLU A OE2 1 
ATOM   4181 N  N   . ASP A 1 563 ? -20.033 -57.152 -44.783 1.00 37.19  ? 826  ASP A N   1 
ATOM   4182 C  CA  . ASP A 1 563 ? -20.943 -58.329 -44.748 1.00 38.21  ? 826  ASP A CA  1 
ATOM   4183 C  C   . ASP A 1 563 ? -21.892 -58.211 -43.550 1.00 36.66  ? 826  ASP A C   1 
ATOM   4184 O  O   . ASP A 1 563 ? -21.394 -58.246 -42.394 1.00 37.58  ? 826  ASP A O   1 
ATOM   4185 C  CB  . ASP A 1 563 ? -20.125 -59.609 -44.700 1.00 38.24  ? 826  ASP A CB  1 
ATOM   4186 C  CG  . ASP A 1 563 ? -20.962 -60.867 -44.517 1.00 39.91  ? 826  ASP A CG  1 
ATOM   4187 O  OD1 . ASP A 1 563 ? -22.212 -60.746 -44.415 1.00 40.83  ? 826  ASP A OD1 1 
ATOM   4188 O  OD2 . ASP A 1 563 ? -20.343 -61.935 -44.402 1.00 44.53  ? 826  ASP A OD2 1 
ATOM   4189 N  N   . LYS A 1 564 ? -23.203 -58.154 -43.796 1.00 32.40  ? 827  LYS A N   1 
ATOM   4190 C  CA  . LYS A 1 564 ? -24.237 -57.890 -42.762 1.00 32.51  ? 827  LYS A CA  1 
ATOM   4191 C  C   . LYS A 1 564 ? -24.904 -59.194 -42.298 1.00 30.04  ? 827  LYS A C   1 
ATOM   4192 O  O   . LYS A 1 564 ? -25.955 -59.105 -41.621 1.00 32.69  ? 827  LYS A O   1 
ATOM   4193 C  CB  . LYS A 1 564 ? -25.281 -56.883 -43.234 1.00 33.61  ? 827  LYS A CB  1 
ATOM   4194 C  CG  . LYS A 1 564 ? -24.729 -55.522 -43.628 1.00 39.01  ? 827  LYS A CG  1 
ATOM   4195 C  CD  . LYS A 1 564 ? -23.912 -54.869 -42.543 1.00 32.56  ? 827  LYS A CD  1 
ATOM   4196 C  CE  . LYS A 1 564 ? -23.745 -53.390 -42.779 1.00 32.90  ? 827  LYS A CE  1 
ATOM   4197 N  NZ  . LYS A 1 564 ? -22.815 -52.801 -41.773 1.00 33.22  ? 827  LYS A NZ  1 
ATOM   4198 N  N   . THR A 1 565 ? -24.265 -60.339 -42.505 1.00 32.59  ? 828  THR A N   1 
ATOM   4199 C  CA  . THR A 1 565 ? -24.832 -61.649 -42.075 1.00 34.38  ? 828  THR A CA  1 
ATOM   4200 C  C   . THR A 1 565 ? -24.944 -61.651 -40.554 1.00 36.26  ? 828  THR A C   1 
ATOM   4201 O  O   . THR A 1 565 ? -23.914 -61.505 -39.890 1.00 33.81  ? 828  THR A O   1 
ATOM   4202 C  CB  . THR A 1 565 ? -23.943 -62.794 -42.572 1.00 40.82  ? 828  THR A CB  1 
ATOM   4203 O  OG1 . THR A 1 565 ? -23.837 -62.653 -43.987 1.00 40.31  ? 828  THR A OG1 1 
ATOM   4204 C  CG2 . THR A 1 565 ? -24.453 -64.167 -42.209 1.00 40.88  ? 828  THR A CG2 1 
ATOM   4205 N  N   . PRO A 1 566 ? -26.156 -61.811 -39.965 1.00 42.01  ? 829  PRO A N   1 
ATOM   4206 C  CA  . PRO A 1 566 ? -26.314 -61.788 -38.514 1.00 42.98  ? 829  PRO A CA  1 
ATOM   4207 C  C   . PRO A 1 566 ? -25.610 -62.994 -37.893 1.00 41.23  ? 829  PRO A C   1 
ATOM   4208 O  O   . PRO A 1 566 ? -25.456 -64.013 -38.529 1.00 34.04  ? 829  PRO A O   1 
ATOM   4209 C  CB  . PRO A 1 566 ? -27.832 -61.829 -38.279 1.00 45.27  ? 829  PRO A CB  1 
ATOM   4210 C  CG  . PRO A 1 566 ? -28.439 -61.503 -39.629 1.00 42.92  ? 829  PRO A CG  1 
ATOM   4211 C  CD  . PRO A 1 566 ? -27.450 -62.009 -40.644 1.00 44.46  ? 829  PRO A CD  1 
ATOM   4212 N  N   . VAL A 1 567 ? -25.152 -62.826 -36.658 1.00 36.29  ? 830  VAL A N   1 
ATOM   4213 C  CA  . VAL A 1 567 ? -24.609 -63.933 -35.833 1.00 35.04  ? 830  VAL A CA  1 
ATOM   4214 C  C   . VAL A 1 567 ? -25.816 -64.611 -35.173 1.00 31.19  ? 830  VAL A C   1 
ATOM   4215 O  O   . VAL A 1 567 ? -26.691 -63.887 -34.672 1.00 32.64  ? 830  VAL A O   1 
ATOM   4216 C  CB  . VAL A 1 567 ? -23.599 -63.335 -34.832 1.00 38.23  ? 830  VAL A CB  1 
ATOM   4217 C  CG1 . VAL A 1 567 ? -23.499 -64.144 -33.595 1.00 42.83  ? 830  VAL A CG1 1 
ATOM   4218 C  CG2 . VAL A 1 567 ? -22.251 -63.155 -35.493 1.00 38.27  ? 830  VAL A CG2 1 
ATOM   4219 N  N   . GLU A 1 568 ? -25.838 -65.937 -35.123 1.00 36.23  ? 831  GLU A N   1 
ATOM   4220 C  CA  . GLU A 1 568 ? -27.026 -66.703 -34.631 1.00 38.38  ? 831  GLU A CA  1 
ATOM   4221 C  C   . GLU A 1 568 ? -26.866 -67.086 -33.168 1.00 34.70  ? 831  GLU A C   1 
ATOM   4222 O  O   . GLU A 1 568 ? -27.886 -67.428 -32.512 1.00 33.67  ? 831  GLU A O   1 
ATOM   4223 C  CB  . GLU A 1 568 ? -27.194 -67.986 -35.463 1.00 45.08  ? 831  GLU A CB  1 
ATOM   4224 C  CG  . GLU A 1 568 ? -27.499 -67.727 -36.933 1.00 49.72  ? 831  GLU A CG  1 
ATOM   4225 C  CD  . GLU A 1 568 ? -28.848 -67.072 -37.193 1.00 53.04  ? 831  GLU A CD  1 
ATOM   4226 O  OE1 . GLU A 1 568 ? -29.824 -67.385 -36.467 1.00 54.15  ? 831  GLU A OE1 1 
ATOM   4227 O  OE2 . GLU A 1 568 ? -28.928 -66.249 -38.120 1.00 59.82  ? 831  GLU A OE2 1 
ATOM   4228 N  N   . SER A 1 569 ? -25.644 -67.088 -32.627 1.00 30.59  ? 832  SER A N   1 
ATOM   4229 C  CA  . SER A 1 569 ? -25.416 -67.503 -31.230 1.00 26.67  ? 832  SER A CA  1 
ATOM   4230 C  C   . SER A 1 569 ? -24.136 -66.849 -30.686 1.00 30.25  ? 832  SER A C   1 
ATOM   4231 O  O   . SER A 1 569 ? -23.260 -66.388 -31.491 1.00 28.49  ? 832  SER A O   1 
ATOM   4232 C  CB  . SER A 1 569 ? -25.317 -68.986 -31.062 1.00 34.31  ? 832  SER A CB  1 
ATOM   4233 O  OG  . SER A 1 569 ? -24.057 -69.468 -31.468 1.00 35.66  ? 832  SER A OG  1 
ATOM   4234 N  N   . TRP A 1 570 ? -24.064 -66.790 -29.374 1.00 27.39  ? 833  TRP A N   1 
ATOM   4235 C  CA  . TRP A 1 570 ? -22.884 -66.191 -28.682 1.00 30.93  ? 833  TRP A CA  1 
ATOM   4236 C  C   . TRP A 1 570 ? -21.617 -67.013 -29.019 1.00 31.45  ? 833  TRP A C   1 
ATOM   4237 O  O   . TRP A 1 570 ? -20.516 -66.454 -29.078 1.00 29.25  ? 833  TRP A O   1 
ATOM   4238 C  CB  . TRP A 1 570 ? -23.192 -66.093 -27.177 1.00 27.83  ? 833  TRP A CB  1 
ATOM   4239 C  CG  . TRP A 1 570 ? -24.026 -64.930 -26.799 1.00 29.44  ? 833  TRP A CG  1 
ATOM   4240 C  CD1 . TRP A 1 570 ? -25.369 -64.933 -26.552 1.00 29.12  ? 833  TRP A CD1 1 
ATOM   4241 C  CD2 . TRP A 1 570 ? -23.588 -63.560 -26.679 1.00 27.52  ? 833  TRP A CD2 1 
ATOM   4242 N  NE1 . TRP A 1 570 ? -25.777 -63.661 -26.263 1.00 33.55  ? 833  TRP A NE1 1 
ATOM   4243 C  CE2 . TRP A 1 570 ? -24.716 -62.795 -26.357 1.00 28.75  ? 833  TRP A CE2 1 
ATOM   4244 C  CE3 . TRP A 1 570 ? -22.350 -62.910 -26.801 1.00 28.31  ? 833  TRP A CE3 1 
ATOM   4245 C  CZ2 . TRP A 1 570 ? -24.645 -61.425 -26.081 1.00 31.68  ? 833  TRP A CZ2 1 
ATOM   4246 C  CZ3 . TRP A 1 570 ? -22.291 -61.552 -26.598 1.00 26.98  ? 833  TRP A CZ3 1 
ATOM   4247 C  CH2 . TRP A 1 570 ? -23.423 -60.815 -26.254 1.00 29.64  ? 833  TRP A CH2 1 
ATOM   4248 N  N   . GLU A 1 571 ? -21.730 -68.292 -29.383 1.00 31.28  ? 834  GLU A N   1 
ATOM   4249 C  CA  . GLU A 1 571 ? -20.546 -69.153 -29.679 1.00 36.19  ? 834  GLU A CA  1 
ATOM   4250 C  C   . GLU A 1 571 ? -19.838 -68.697 -30.959 1.00 32.02  ? 834  GLU A C   1 
ATOM   4251 O  O   . GLU A 1 571 ? -18.612 -68.908 -31.047 1.00 34.49  ? 834  GLU A O   1 
ATOM   4252 C  CB  . GLU A 1 571 ? -20.950 -70.638 -29.674 1.00 45.27  ? 834  GLU A CB  1 
ATOM   4253 C  CG  . GLU A 1 571 ? -21.519 -71.045 -28.317 1.00 56.12  ? 834  GLU A CG  1 
ATOM   4254 C  CD  . GLU A 1 571 ? -21.596 -72.522 -27.930 1.00 69.58  ? 834  GLU A CD  1 
ATOM   4255 O  OE1 . GLU A 1 571 ? -20.844 -73.355 -28.500 1.00 80.52  ? 834  GLU A OE1 1 
ATOM   4256 O  OE2 . GLU A 1 571 ? -22.418 -72.841 -27.028 1.00 76.02  ? 834  GLU A OE2 1 
ATOM   4257 N  N   . GLU A 1 572 ? -20.510 -67.995 -31.846 1.00 32.35  ? 835  GLU A N   1 
ATOM   4258 C  CA  . GLU A 1 572 ? -19.882 -67.386 -33.044 1.00 32.43  ? 835  GLU A CA  1 
ATOM   4259 C  C   . GLU A 1 572 ? -19.032 -66.156 -32.676 1.00 31.47  ? 835  GLU A C   1 
ATOM   4260 O  O   . GLU A 1 572 ? -18.364 -65.639 -33.585 1.00 33.64  ? 835  GLU A O   1 
ATOM   4261 C  CB  . GLU A 1 572 ? -20.894 -66.856 -34.056 1.00 32.43  ? 835  GLU A CB  1 
ATOM   4262 C  CG  . GLU A 1 572 ? -21.587 -67.926 -34.869 1.00 43.07  ? 835  GLU A CG  1 
ATOM   4263 C  CD  . GLU A 1 572 ? -22.563 -67.329 -35.899 1.00 44.77  ? 835  GLU A CD  1 
ATOM   4264 O  OE1 . GLU A 1 572 ? -22.117 -66.614 -36.825 1.00 46.12  ? 835  GLU A OE1 1 
ATOM   4265 O  OE2 . GLU A 1 572 ? -23.759 -67.581 -35.784 1.00 44.78  ? 835  GLU A OE2 1 
ATOM   4266 N  N   . ILE A 1 573 ? -19.171 -65.616 -31.471 1.00 26.84  ? 836  ILE A N   1 
ATOM   4267 C  CA  . ILE A 1 573 ? -18.540 -64.314 -31.099 1.00 27.36  ? 836  ILE A CA  1 
ATOM   4268 C  C   . ILE A 1 573 ? -17.232 -64.650 -30.390 1.00 25.62  ? 836  ILE A C   1 
ATOM   4269 O  O   . ILE A 1 573 ? -17.241 -65.358 -29.391 1.00 23.62  ? 836  ILE A O   1 
ATOM   4270 C  CB  . ILE A 1 573 ? -19.500 -63.462 -30.260 1.00 26.49  ? 836  ILE A CB  1 
ATOM   4271 C  CG1 . ILE A 1 573 ? -20.754 -63.126 -31.045 1.00 25.23  ? 836  ILE A CG1 1 
ATOM   4272 C  CG2 . ILE A 1 573 ? -18.784 -62.196 -29.775 1.00 29.78  ? 836  ILE A CG2 1 
ATOM   4273 C  CD1 . ILE A 1 573 ? -21.852 -62.444 -30.260 1.00 25.69  ? 836  ILE A CD1 1 
ATOM   4274 N  N   . PRO A 1 574 ? -16.066 -64.206 -30.919 1.00 26.06  ? 837  PRO A N   1 
ATOM   4275 C  CA  . PRO A 1 574 ? -14.768 -64.667 -30.436 1.00 26.52  ? 837  PRO A CA  1 
ATOM   4276 C  C   . PRO A 1 574 ? -14.302 -63.982 -29.133 1.00 24.96  ? 837  PRO A C   1 
ATOM   4277 O  O   . PRO A 1 574 ? -14.835 -62.969 -28.703 1.00 21.67  ? 837  PRO A O   1 
ATOM   4278 C  CB  . PRO A 1 574 ? -13.843 -64.256 -31.589 1.00 26.99  ? 837  PRO A CB  1 
ATOM   4279 C  CG  . PRO A 1 574 ? -14.448 -62.971 -32.063 1.00 29.50  ? 837  PRO A CG  1 
ATOM   4280 C  CD  . PRO A 1 574 ? -15.950 -63.176 -31.962 1.00 28.24  ? 837  PRO A CD  1 
ATOM   4281 N  N   . TYR A 1 575 ? -13.275 -64.570 -28.532 1.00 23.97  ? 838  TYR A N   1 
ATOM   4282 C  CA  . TYR A 1 575 ? -12.478 -63.993 -27.425 1.00 23.42  ? 838  TYR A CA  1 
ATOM   4283 C  C   . TYR A 1 575 ? -11.125 -63.505 -27.958 1.00 25.01  ? 838  TYR A C   1 
ATOM   4284 O  O   . TYR A 1 575 ? -10.615 -63.994 -29.015 1.00 22.58  ? 838  TYR A O   1 
ATOM   4285 C  CB  . TYR A 1 575 ? -12.254 -65.073 -26.368 1.00 23.47  ? 838  TYR A CB  1 
ATOM   4286 C  CG  . TYR A 1 575 ? -13.508 -65.595 -25.683 1.00 23.14  ? 838  TYR A CG  1 
ATOM   4287 C  CD1 . TYR A 1 575 ? -14.183 -64.830 -24.741 1.00 21.78  ? 838  TYR A CD1 1 
ATOM   4288 C  CD2 . TYR A 1 575 ? -14.020 -66.851 -25.968 1.00 28.14  ? 838  TYR A CD2 1 
ATOM   4289 C  CE1 . TYR A 1 575 ? -15.322 -65.305 -24.097 1.00 25.21  ? 838  TYR A CE1 1 
ATOM   4290 C  CE2 . TYR A 1 575 ? -15.118 -67.361 -25.297 1.00 30.35  ? 838  TYR A CE2 1 
ATOM   4291 C  CZ  . TYR A 1 575 ? -15.789 -66.573 -24.374 1.00 28.72  ? 838  TYR A CZ  1 
ATOM   4292 O  OH  . TYR A 1 575 ? -16.918 -67.015 -23.732 1.00 29.58  ? 838  TYR A OH  1 
ATOM   4293 N  N   . LEU A 1 576 ? -10.439 -62.694 -27.150 1.00 20.96  ? 839  LEU A N   1 
ATOM   4294 C  CA  . LEU A 1 576 ? -8.982  -62.480 -27.295 1.00 21.58  ? 839  LEU A CA  1 
ATOM   4295 C  C   . LEU A 1 576 ? -8.287  -63.830 -27.234 1.00 22.06  ? 839  LEU A C   1 
ATOM   4296 O  O   . LEU A 1 576 ? -8.829  -64.757 -26.591 1.00 20.62  ? 839  LEU A O   1 
ATOM   4297 C  CB  . LEU A 1 576 ? -8.493  -61.604 -26.126 1.00 22.47  ? 839  LEU A CB  1 
ATOM   4298 C  CG  . LEU A 1 576 ? -9.068  -60.189 -26.047 1.00 19.34  ? 839  LEU A CG  1 
ATOM   4299 C  CD1 . LEU A 1 576 ? -8.356  -59.380 -24.967 1.00 22.12  ? 839  LEU A CD1 1 
ATOM   4300 C  CD2 . LEU A 1 576 ? -8.950  -59.459 -27.352 1.00 24.12  ? 839  LEU A CD2 1 
ATOM   4301 N  N   . GLY A 1 577 ? -7.071  -63.939 -27.771 1.00 23.72  ? 840  GLY A N   1 
ATOM   4302 C  CA  . GLY A 1 577 ? -6.186  -65.084 -27.419 1.00 24.55  ? 840  GLY A CA  1 
ATOM   4303 C  C   . GLY A 1 577 ? -6.098  -65.297 -25.909 1.00 22.46  ? 840  GLY A C   1 
ATOM   4304 O  O   . GLY A 1 577 ? -6.194  -64.334 -25.138 1.00 21.73  ? 840  GLY A O   1 
ATOM   4305 N  N   . LYS A 1 578 ? -5.934  -66.549 -25.488 0.70 21.95  ? 841  LYS A N   1 
ATOM   4306 C  CA  . LYS A 1 578 ? -5.795  -66.916 -24.052 0.70 23.28  ? 841  LYS A CA  1 
ATOM   4307 C  C   . LYS A 1 578 ? -4.671  -66.086 -23.402 0.70 22.14  ? 841  LYS A C   1 
ATOM   4308 O  O   . LYS A 1 578 ? -4.902  -65.511 -22.327 0.70 19.91  ? 841  LYS A O   1 
ATOM   4309 C  CB  . LYS A 1 578 ? -5.521  -68.410 -23.915 0.70 24.40  ? 841  LYS A CB  1 
ATOM   4310 C  CG  . LYS A 1 578 ? -6.684  -69.338 -24.269 0.70 24.57  ? 841  LYS A CG  1 
ATOM   4311 C  CD  . LYS A 1 578 ? -6.339  -70.825 -24.109 0.70 26.84  ? 841  LYS A CD  1 
ATOM   4312 C  CE  . LYS A 1 578 ? -5.389  -71.384 -25.148 0.70 24.62  ? 841  LYS A CE  1 
ATOM   4313 N  NZ  . LYS A 1 578 ? -5.938  -71.245 -26.511 0.70 26.45  ? 841  LYS A NZ  1 
ATOM   4314 N  N   . ARG A 1 579 ? -3.511  -65.974 -24.052 1.00 21.17  ? 842  ARG A N   1 
ATOM   4315 C  CA  . ARG A 1 579 ? -2.363  -65.266 -23.470 1.00 20.81  ? 842  ARG A CA  1 
ATOM   4316 C  C   . ARG A 1 579 ? -2.652  -63.757 -23.426 1.00 20.35  ? 842  ARG A C   1 
ATOM   4317 O  O   . ARG A 1 579 ? -2.335  -63.090 -22.381 1.00 19.53  ? 842  ARG A O   1 
ATOM   4318 C  CB  . ARG A 1 579 ? -1.058  -65.648 -24.200 1.00 20.65  ? 842  ARG A CB  1 
ATOM   4319 C  CG  . ARG A 1 579 ? 0.142   -65.157 -23.425 1.00 21.32  ? 842  ARG A CG  1 
ATOM   4320 C  CD  . ARG A 1 579 ? 1.464   -65.352 -24.188 1.00 24.20  ? 842  ARG A CD  1 
ATOM   4321 N  NE  . ARG A 1 579 ? 1.639   -66.798 -24.319 1.00 26.05  ? 842  ARG A NE  1 
ATOM   4322 C  CZ  . ARG A 1 579 ? 2.119   -67.573 -23.381 1.00 32.25  ? 842  ARG A CZ  1 
ATOM   4323 N  NH1 . ARG A 1 579 ? 2.193   -68.875 -23.596 1.00 43.41  ? 842  ARG A NH1 1 
ATOM   4324 N  NH2 . ARG A 1 579 ? 2.580   -67.063 -22.254 1.00 36.19  ? 842  ARG A NH2 1 
ATOM   4325 N  N   . GLU A 1 580 ? -3.258  -63.209 -24.456 1.00 21.13  ? 843  GLU A N   1 
ATOM   4326 C  CA  . GLU A 1 580 ? -3.636  -61.755 -24.495 1.00 21.35  ? 843  GLU A CA  1 
ATOM   4327 C  C   . GLU A 1 580 ? -4.643  -61.452 -23.376 1.00 19.94  ? 843  GLU A C   1 
ATOM   4328 O  O   . GLU A 1 580 ? -4.600  -60.408 -22.771 1.00 20.19  ? 843  GLU A O   1 
ATOM   4329 C  CB  . GLU A 1 580 ? -4.270  -61.433 -25.844 1.00 22.94  ? 843  GLU A CB  1 
ATOM   4330 C  CG  . GLU A 1 580 ? -3.377  -61.662 -27.038 1.00 27.76  ? 843  GLU A CG  1 
ATOM   4331 C  CD  . GLU A 1 580 ? -4.110  -61.292 -28.325 1.00 36.66  ? 843  GLU A CD  1 
ATOM   4332 O  OE1 . GLU A 1 580 ? -5.146  -61.965 -28.671 1.00 31.96  ? 843  GLU A OE1 1 
ATOM   4333 O  OE2 . GLU A 1 580 ? -3.761  -60.236 -28.910 1.00 38.09  ? 843  GLU A OE2 1 
ATOM   4334 N  N   . ASP A 1 581 ? -5.572  -62.360 -23.126 1.00 19.13  ? 844  ASP A N   1 
ATOM   4335 C  CA  . ASP A 1 581 ? -6.629  -62.197 -22.087 1.00 19.18  ? 844  ASP A CA  1 
ATOM   4336 C  C   . ASP A 1 581 ? -5.946  -62.127 -20.725 1.00 19.14  ? 844  ASP A C   1 
ATOM   4337 O  O   . ASP A 1 581 ? -6.227  -61.198 -19.954 1.00 18.53  ? 844  ASP A O   1 
ATOM   4338 C  CB  . ASP A 1 581 ? -7.658  -63.326 -22.185 1.00 20.05  ? 844  ASP A CB  1 
ATOM   4339 C  CG  . ASP A 1 581 ? -9.081  -63.020 -21.683 1.00 21.61  ? 844  ASP A CG  1 
ATOM   4340 O  OD1 . ASP A 1 581 ? -9.297  -61.985 -21.045 1.00 20.00  ? 844  ASP A OD1 1 
ATOM   4341 O  OD2 . ASP A 1 581 ? -9.951  -63.870 -21.912 1.00 19.88  ? 844  ASP A OD2 1 
ATOM   4342 N  N   . GLN A 1 582 ? -4.961  -63.005 -20.476 1.00 19.89  ? 845  GLN A N   1 
ATOM   4343 C  CA  . GLN A 1 582 ? -4.149  -62.947 -19.236 1.00 20.68  ? 845  GLN A CA  1 
ATOM   4344 C  C   . GLN A 1 582 ? -3.371  -61.643 -19.169 1.00 18.25  ? 845  GLN A C   1 
ATOM   4345 O  O   . GLN A 1 582 ? -3.390  -60.988 -18.082 1.00 19.76  ? 845  GLN A O   1 
ATOM   4346 C  CB  . GLN A 1 582 ? -3.191  -64.158 -19.112 1.00 22.42  ? 845  GLN A CB  1 
ATOM   4347 C  CG  . GLN A 1 582 ? -3.890  -65.474 -18.935 1.00 23.54  ? 845  GLN A CG  1 
ATOM   4348 C  CD  . GLN A 1 582 ? -2.897  -66.629 -19.010 1.00 30.61  ? 845  GLN A CD  1 
ATOM   4349 O  OE1 . GLN A 1 582 ? -1.890  -66.557 -19.706 1.00 29.93  ? 845  GLN A OE1 1 
ATOM   4350 N  NE2 . GLN A 1 582 ? -3.163  -67.684 -18.260 1.00 29.62  ? 845  GLN A NE2 1 
ATOM   4351 N  N   . TRP A 1 583 ? -2.680  -61.230 -20.247 1.00 18.56  ? 846  TRP A N   1 
ATOM   4352 C  CA  . TRP A 1 583 ? -1.926  -59.945 -20.242 1.00 17.70  ? 846  TRP A CA  1 
ATOM   4353 C  C   . TRP A 1 583 ? -2.825  -58.770 -19.786 1.00 20.62  ? 846  TRP A C   1 
ATOM   4354 O  O   . TRP A 1 583 ? -2.362  -57.871 -19.049 1.00 18.72  ? 846  TRP A O   1 
ATOM   4355 C  CB  . TRP A 1 583 ? -1.356  -59.650 -21.637 1.00 18.38  ? 846  TRP A CB  1 
ATOM   4356 C  CG  . TRP A 1 583 ? -0.188  -60.531 -21.999 1.00 19.47  ? 846  TRP A CG  1 
ATOM   4357 C  CD1 . TRP A 1 583 ? 0.623   -61.203 -21.134 1.00 22.62  ? 846  TRP A CD1 1 
ATOM   4358 C  CD2 . TRP A 1 583 ? 0.325   -60.809 -23.311 1.00 19.70  ? 846  TRP A CD2 1 
ATOM   4359 N  NE1 . TRP A 1 583 ? 1.605   -61.875 -21.817 1.00 24.08  ? 846  TRP A NE1 1 
ATOM   4360 C  CE2 . TRP A 1 583 ? 1.454   -61.646 -23.148 1.00 22.03  ? 846  TRP A CE2 1 
ATOM   4361 C  CE3 . TRP A 1 583 ? -0.014  -60.391 -24.590 1.00 23.14  ? 846  TRP A CE3 1 
ATOM   4362 C  CZ2 . TRP A 1 583 ? 2.232   -62.055 -24.229 1.00 24.32  ? 846  TRP A CZ2 1 
ATOM   4363 C  CZ3 . TRP A 1 583 ? 0.721   -60.849 -25.667 1.00 24.77  ? 846  TRP A CZ3 1 
ATOM   4364 C  CH2 . TRP A 1 583 ? 1.823   -61.671 -25.481 1.00 23.38  ? 846  TRP A CH2 1 
ATOM   4365 N  N   . CYS A 1 584 ? -4.093  -58.788 -20.228 1.00 19.08  ? 847  CYS A N   1 
ATOM   4366 C  CA  . CYS A 1 584 ? -5.055  -57.713 -19.890 1.00 18.53  ? 847  CYS A CA  1 
ATOM   4367 C  C   . CYS A 1 584 ? -5.843  -58.013 -18.597 1.00 19.65  ? 847  CYS A C   1 
ATOM   4368 O  O   . CYS A 1 584 ? -6.879  -57.364 -18.396 1.00 20.57  ? 847  CYS A O   1 
ATOM   4369 C  CB  . CYS A 1 584 ? -5.922  -57.422 -21.093 1.00 19.39  ? 847  CYS A CB  1 
ATOM   4370 S  SG  . CYS A 1 584 ? -5.001  -56.692 -22.455 1.00 20.47  ? 847  CYS A SG  1 
ATOM   4371 N  N   . GLY A 1 585 ? -5.347  -58.921 -17.730 1.00 21.83  ? 848  GLY A N   1 
ATOM   4372 C  CA  . GLY A 1 585 ? -5.747  -59.115 -16.310 1.00 20.72  ? 848  GLY A CA  1 
ATOM   4373 C  C   . GLY A 1 585 ? -6.664  -60.306 -16.071 1.00 20.59  ? 848  GLY A C   1 
ATOM   4374 O  O   . GLY A 1 585 ? -7.143  -60.406 -14.955 1.00 23.36  ? 848  GLY A O   1 
ATOM   4375 N  N   . SER A 1 586 ? -6.936  -61.173 -17.052 1.00 20.36  ? 849  SER A N   1 
ATOM   4376 C  CA  . SER A 1 586 ? -7.776  -62.391 -16.890 1.00 20.97  ? 849  SER A CA  1 
ATOM   4377 C  C   . SER A 1 586 ? -7.198  -63.287 -15.772 1.00 23.01  ? 849  SER A C   1 
ATOM   4378 O  O   . SER A 1 586 ? -5.966  -63.467 -15.673 1.00 20.77  ? 849  SER A O   1 
ATOM   4379 C  CB  . SER A 1 586 ? -7.868  -63.202 -18.146 1.00 20.27  ? 849  SER A CB  1 
ATOM   4380 O  OG  . SER A 1 586 ? -8.804  -64.254 -17.937 1.00 21.14  ? 849  SER A OG  1 
ATOM   4381 N  N   . LEU A 1 587 ? -8.079  -63.925 -15.020 1.00 20.91  ? 850  LEU A N   1 
ATOM   4382 C  CA  . LEU A 1 587 ? -7.697  -64.968 -14.052 1.00 21.33  ? 850  LEU A CA  1 
ATOM   4383 C  C   . LEU A 1 587 ? -7.726  -66.380 -14.644 1.00 23.98  ? 850  LEU A C   1 
ATOM   4384 O  O   . LEU A 1 587 ? -7.487  -67.310 -13.860 1.00 26.77  ? 850  LEU A O   1 
ATOM   4385 C  CB  . LEU A 1 587 ? -8.592  -64.868 -12.795 1.00 22.27  ? 850  LEU A CB  1 
ATOM   4386 C  CG  . LEU A 1 587 ? -8.553  -63.565 -11.994 1.00 24.94  ? 850  LEU A CG  1 
ATOM   4387 C  CD1 . LEU A 1 587 ? -9.272  -63.725 -10.644 1.00 27.25  ? 850  LEU A CD1 1 
ATOM   4388 C  CD2 . LEU A 1 587 ? -7.138  -62.993 -11.838 1.00 28.21  ? 850  LEU A CD2 1 
ATOM   4389 N  N   . ILE A 1 588 ? -8.002  -66.545 -15.954 0.70 22.40  ? 851  ILE A N   1 
ATOM   4390 C  CA  . ILE A 1 588 ? -7.989  -67.894 -16.596 0.70 25.37  ? 851  ILE A CA  1 
ATOM   4391 C  C   . ILE A 1 588 ? -6.645  -68.546 -16.235 0.70 25.98  ? 851  ILE A C   1 
ATOM   4392 O  O   . ILE A 1 588 ? -5.597  -67.850 -16.267 0.70 25.88  ? 851  ILE A O   1 
ATOM   4393 C  CB  . ILE A 1 588 ? -8.240  -67.909 -18.122 0.70 24.50  ? 851  ILE A CB  1 
ATOM   4394 C  CG1 . ILE A 1 588 ? -7.253  -67.021 -18.893 0.70 24.64  ? 851  ILE A CG1 1 
ATOM   4395 C  CG2 . ILE A 1 588 ? -9.688  -67.546 -18.438 0.70 23.24  ? 851  ILE A CG2 1 
ATOM   4396 C  CD1 . ILE A 1 588 ? -7.526  -66.937 -20.381 0.70 24.34  ? 851  ILE A CD1 1 
ATOM   4397 N  N   . GLY A 1 589 ? -6.693  -69.816 -15.841 1.00 29.48  ? 852  GLY A N   1 
ATOM   4398 C  CA  . GLY A 1 589 ? -5.474  -70.561 -15.460 1.00 29.78  ? 852  GLY A CA  1 
ATOM   4399 C  C   . GLY A 1 589 ? -5.303  -70.625 -13.956 1.00 34.44  ? 852  GLY A C   1 
ATOM   4400 O  O   . GLY A 1 589 ? -4.539  -71.462 -13.505 1.00 36.31  ? 852  GLY A O   1 
ATOM   4401 N  N   . LEU A 1 590 ? -5.957  -69.786 -13.165 1.00 29.18  ? 853  LEU A N   1 
ATOM   4402 C  CA  . LEU A 1 590 ? -5.859  -69.874 -11.685 1.00 30.46  ? 853  LEU A CA  1 
ATOM   4403 C  C   . LEU A 1 590 ? -6.905  -70.872 -11.158 1.00 33.75  ? 853  LEU A C   1 
ATOM   4404 O  O   . LEU A 1 590 ? -8.052  -70.924 -11.653 1.00 29.00  ? 853  LEU A O   1 
ATOM   4405 C  CB  . LEU A 1 590 ? -6.100  -68.546 -10.980 1.00 29.59  ? 853  LEU A CB  1 
ATOM   4406 C  CG  . LEU A 1 590 ? -5.143  -67.386 -11.274 1.00 38.78  ? 853  LEU A CG  1 
ATOM   4407 C  CD1 . LEU A 1 590 ? -5.512  -66.219 -10.368 1.00 40.06  ? 853  LEU A CD1 1 
ATOM   4408 C  CD2 . LEU A 1 590 ? -3.686  -67.785 -11.077 1.00 39.14  ? 853  LEU A CD2 1 
ATOM   4409 N  N   . THR A 1 591 ? -6.560  -71.553 -10.071 1.00 31.87  ? 854  THR A N   1 
ATOM   4410 C  CA  . THR A 1 591 ? -7.468  -72.465 -9.320  1.00 34.14  ? 854  THR A CA  1 
ATOM   4411 C  C   . THR A 1 591 ? -8.700  -71.726 -8.803  1.00 27.81  ? 854  THR A C   1 
ATOM   4412 O  O   . THR A 1 591 ? -9.796  -72.297 -8.909  1.00 29.22  ? 854  THR A O   1 
ATOM   4413 C  CB  . THR A 1 591 ? -6.701  -73.089 -8.142  1.00 37.51  ? 854  THR A CB  1 
ATOM   4414 O  OG1 . THR A 1 591 ? -5.681  -73.822 -8.803  1.00 42.94  ? 854  THR A OG1 1 
ATOM   4415 C  CG2 . THR A 1 591 ? -7.546  -73.980 -7.267  1.00 43.99  ? 854  THR A CG2 1 
ATOM   4416 N  N   . SER A 1 592 ? -8.549  -70.562 -8.182  1.00 26.83  ? 855  SER A N   1 
ATOM   4417 C  CA  . SER A 1 592 ? -9.703  -69.742 -7.724  1.00 27.41  ? 855  SER A CA  1 
ATOM   4418 C  C   . SER A 1 592 ? -10.729 -69.547 -8.878  1.00 25.85  ? 855  SER A C   1 
ATOM   4419 O  O   . SER A 1 592 ? -11.933 -69.702 -8.638  1.00 27.93  ? 855  SER A O   1 
ATOM   4420 C  CB  . SER A 1 592 ? -9.278  -68.460 -7.073  1.00 28.15  ? 855  SER A CB  1 
ATOM   4421 O  OG  . SER A 1 592 ? -8.593  -67.581 -7.968  1.00 33.13  ? 855  SER A OG  1 
ATOM   4422 N  N   . ARG A 1 593 ? -10.281 -69.254 -10.081 1.00 26.28  ? 856  ARG A N   1 
ATOM   4423 C  CA  . ARG A 1 593 ? -11.161 -68.905 -11.233 1.00 26.14  ? 856  ARG A CA  1 
ATOM   4424 C  C   . ARG A 1 593 ? -11.846 -70.199 -11.692 1.00 26.16  ? 856  ARG A C   1 
ATOM   4425 O  O   . ARG A 1 593 ? -13.029 -70.155 -12.052 1.00 25.51  ? 856  ARG A O   1 
ATOM   4426 C  CB  . ARG A 1 593 ? -10.317 -68.259 -12.334 1.00 24.97  ? 856  ARG A CB  1 
ATOM   4427 C  CG  . ARG A 1 593 ? -11.089 -67.625 -13.486 1.00 23.66  ? 856  ARG A CG  1 
ATOM   4428 C  CD  . ARG A 1 593 ? -11.554 -68.607 -14.508 1.00 23.61  ? 856  ARG A CD  1 
ATOM   4429 N  NE  . ARG A 1 593 ? -12.093 -67.851 -15.619 1.00 24.09  ? 856  ARG A NE  1 
ATOM   4430 C  CZ  . ARG A 1 593 ? -12.878 -68.330 -16.581 1.00 25.38  ? 856  ARG A CZ  1 
ATOM   4431 N  NH1 . ARG A 1 593 ? -13.196 -69.614 -16.604 1.00 24.80  ? 856  ARG A NH1 1 
ATOM   4432 N  NH2 . ARG A 1 593 ? -13.351 -67.513 -17.526 1.00 25.10  ? 856  ARG A NH2 1 
ATOM   4433 N  N   . ALA A 1 594 ? -11.107 -71.311 -11.778 1.00 24.63  ? 857  ALA A N   1 
ATOM   4434 C  CA  . ALA A 1 594 ? -11.691 -72.595 -12.235 1.00 27.53  ? 857  ALA A CA  1 
ATOM   4435 C  C   . ALA A 1 594 ? -12.818 -73.026 -11.262 1.00 25.15  ? 857  ALA A C   1 
ATOM   4436 O  O   . ALA A 1 594 ? -13.860 -73.520 -11.718 1.00 26.89  ? 857  ALA A O   1 
ATOM   4437 C  CB  . ALA A 1 594 ? -10.614 -73.650 -12.351 1.00 30.27  ? 857  ALA A CB  1 
ATOM   4438 N  N   . THR A 1 595 ? -12.639 -72.852 -9.967  1.00 27.12  ? 858  THR A N   1 
ATOM   4439 C  CA  . THR A 1 595 ? -13.662 -73.281 -8.993  1.00 30.30  ? 858  THR A CA  1 
ATOM   4440 C  C   . THR A 1 595 ? -14.892 -72.370 -9.143  1.00 29.70  ? 858  THR A C   1 
ATOM   4441 O  O   . THR A 1 595 ? -16.018 -72.858 -9.076  1.00 27.93  ? 858  THR A O   1 
ATOM   4442 C  CB  . THR A 1 595 ? -13.160 -73.172 -7.563  1.00 32.87  ? 858  THR A CB  1 
ATOM   4443 O  OG1 . THR A 1 595 ? -12.008 -74.019 -7.480  1.00 40.41  ? 858  THR A OG1 1 
ATOM   4444 C  CG2 . THR A 1 595 ? -14.240 -73.565 -6.575  1.00 33.78  ? 858  THR A CG2 1 
ATOM   4445 N  N   . TRP A 1 596 ? -14.655 -71.072 -9.307  1.00 24.96  ? 859  TRP A N   1 
ATOM   4446 C  CA  . TRP A 1 596 ? -15.751 -70.086 -9.546  1.00 22.73  ? 859  TRP A CA  1 
ATOM   4447 C  C   . TRP A 1 596 ? -16.566 -70.508 -10.772 1.00 22.14  ? 859  TRP A C   1 
ATOM   4448 O  O   . TRP A 1 596 ? -17.817 -70.559 -10.705 1.00 24.79  ? 859  TRP A O   1 
ATOM   4449 C  CB  . TRP A 1 596 ? -15.109 -68.705 -9.686  1.00 23.95  ? 859  TRP A CB  1 
ATOM   4450 C  CG  . TRP A 1 596 ? -15.978 -67.593 -10.178 1.00 21.17  ? 859  TRP A CG  1 
ATOM   4451 C  CD1 . TRP A 1 596 ? -17.034 -67.048 -9.512  1.00 22.58  ? 859  TRP A CD1 1 
ATOM   4452 C  CD2 . TRP A 1 596 ? -15.873 -66.915 -11.427 1.00 22.25  ? 859  TRP A CD2 1 
ATOM   4453 N  NE1 . TRP A 1 596 ? -17.544 -66.012 -10.233 1.00 21.36  ? 859  TRP A NE1 1 
ATOM   4454 C  CE2 . TRP A 1 596 ? -16.890 -65.935 -11.432 1.00 20.60  ? 859  TRP A CE2 1 
ATOM   4455 C  CE3 . TRP A 1 596 ? -15.026 -67.022 -12.545 1.00 21.47  ? 859  TRP A CE3 1 
ATOM   4456 C  CZ2 . TRP A 1 596 ? -17.033 -65.015 -12.465 1.00 21.33  ? 859  TRP A CZ2 1 
ATOM   4457 C  CZ3 . TRP A 1 596 ? -15.182 -66.129 -13.584 1.00 23.09  ? 859  TRP A CZ3 1 
ATOM   4458 C  CH2 . TRP A 1 596 ? -16.180 -65.132 -13.531 1.00 22.83  ? 859  TRP A CH2 1 
ATOM   4459 N  N   . ALA A 1 597 ? -15.913 -70.751 -11.896 1.00 23.23  ? 860  ALA A N   1 
ATOM   4460 C  CA  . ALA A 1 597 ? -16.590 -71.076 -13.168 1.00 25.09  ? 860  ALA A CA  1 
ATOM   4461 C  C   . ALA A 1 597 ? -17.380 -72.382 -13.033 1.00 29.54  ? 860  ALA A C   1 
ATOM   4462 O  O   . ALA A 1 597 ? -18.574 -72.422 -13.372 1.00 27.87  ? 860  ALA A O   1 
ATOM   4463 C  CB  . ALA A 1 597 ? -15.565 -71.173 -14.266 1.00 24.46  ? 860  ALA A CB  1 
ATOM   4464 N  N   . LYS A 1 598 ? -16.738 -73.413 -12.481 1.00 29.82  ? 861  LYS A N   1 
ATOM   4465 C  CA  . LYS A 1 598 ? -17.398 -74.739 -12.296 1.00 30.48  ? 861  LYS A CA  1 
ATOM   4466 C  C   . LYS A 1 598 ? -18.627 -74.618 -11.416 1.00 27.19  ? 861  LYS A C   1 
ATOM   4467 O  O   . LYS A 1 598 ? -19.644 -75.250 -11.755 1.00 32.97  ? 861  LYS A O   1 
ATOM   4468 C  CB  . LYS A 1 598 ? -16.438 -75.731 -11.639 1.00 34.50  ? 861  LYS A CB  1 
ATOM   4469 C  CG  . LYS A 1 598 ? -16.965 -77.147 -11.474 1.00 43.05  ? 861  LYS A CG  1 
ATOM   4470 C  CD  . LYS A 1 598 ? -15.889 -78.142 -11.070 1.00 53.99  ? 861  LYS A CD  1 
ATOM   4471 C  CE  . LYS A 1 598 ? -16.128 -79.494 -11.716 1.00 64.97  ? 861  LYS A CE  1 
ATOM   4472 N  NZ  . LYS A 1 598 ? -17.534 -79.940 -11.529 1.00 62.86  ? 861  LYS A NZ  1 
ATOM   4473 N  N   . ASN A 1 599 ? -18.559 -73.856 -10.329 1.00 27.85  ? 862  ASN A N   1 
ATOM   4474 C  CA  . ASN A 1 599 ? -19.614 -73.776 -9.296  1.00 27.56  ? 862  ASN A CA  1 
ATOM   4475 C  C   . ASN A 1 599 ? -20.505 -72.543 -9.515  1.00 24.94  ? 862  ASN A C   1 
ATOM   4476 O  O   . ASN A 1 599 ? -21.230 -72.156 -8.571  1.00 26.49  ? 862  ASN A O   1 
ATOM   4477 C  CB  . ASN A 1 599 ? -18.979 -73.777 -7.908  1.00 28.66  ? 862  ASN A CB  1 
ATOM   4478 C  CG  . ASN A 1 599 ? -18.287 -75.094 -7.610  1.00 33.92  ? 862  ASN A CG  1 
ATOM   4479 O  OD1 . ASN A 1 599 ? -18.843 -76.157 -7.825  1.00 37.28  ? 862  ASN A OD1 1 
ATOM   4480 N  ND2 . ASN A 1 599 ? -17.094 -75.029 -7.096  1.00 43.42  ? 862  ASN A ND2 1 
ATOM   4481 N  N   . ILE A 1 600 ? -20.540 -71.967 -10.710 1.00 25.98  ? 863  ILE A N   1 
ATOM   4482 C  CA  . ILE A 1 600 ? -21.214 -70.627 -10.877 1.00 22.92  ? 863  ILE A CA  1 
ATOM   4483 C  C   . ILE A 1 600 ? -22.731 -70.705 -10.537 1.00 25.46  ? 863  ILE A C   1 
ATOM   4484 O  O   . ILE A 1 600 ? -23.309 -69.737 -10.018 1.00 22.56  ? 863  ILE A O   1 
ATOM   4485 C  CB  . ILE A 1 600 ? -20.924 -70.024 -12.255 1.00 21.92  ? 863  ILE A CB  1 
ATOM   4486 C  CG1 . ILE A 1 600 ? -21.271 -68.531 -12.328 1.00 25.11  ? 863  ILE A CG1 1 
ATOM   4487 C  CG2 . ILE A 1 600 ? -21.624 -70.788 -13.398 1.00 24.74  ? 863  ILE A CG2 1 
ATOM   4488 C  CD1 . ILE A 1 600 ? -20.402 -67.683 -11.481 1.00 24.47  ? 863  ILE A CD1 1 
ATOM   4489 N  N   A GLN A 1 601 ? -23.378 -71.842 -10.812 0.25 25.23  ? 864  GLN A N   1 
ATOM   4490 N  N   B GLN A 1 601 ? -23.375 -71.845 -10.801 0.25 24.86  ? 864  GLN A N   1 
ATOM   4491 C  CA  A GLN A 1 601 ? -24.832 -72.008 -10.531 0.25 26.38  ? 864  GLN A CA  1 
ATOM   4492 C  CA  B GLN A 1 601 ? -24.834 -71.997 -10.546 0.25 25.79  ? 864  GLN A CA  1 
ATOM   4493 C  C   A GLN A 1 601 ? -25.100 -71.820 -9.029  0.25 26.15  ? 864  GLN A C   1 
ATOM   4494 C  C   B GLN A 1 601 ? -25.115 -71.856 -9.036  0.25 25.93  ? 864  GLN A C   1 
ATOM   4495 O  O   A GLN A 1 601 ? -26.154 -71.235 -8.679  0.25 25.80  ? 864  GLN A O   1 
ATOM   4496 O  O   B GLN A 1 601 ? -26.193 -71.317 -8.683  0.25 25.91  ? 864  GLN A O   1 
ATOM   4497 C  CB  A GLN A 1 601 ? -25.342 -73.355 -11.042 0.25 27.75  ? 864  GLN A CB  1 
ATOM   4498 C  CB  B GLN A 1 601 ? -25.348 -73.299 -11.165 0.25 26.59  ? 864  GLN A CB  1 
ATOM   4499 C  CG  A GLN A 1 601 ? -25.349 -73.451 -12.560 0.25 29.00  ? 864  GLN A CG  1 
ATOM   4500 C  CG  B GLN A 1 601 ? -26.867 -73.386 -11.257 0.25 26.91  ? 864  GLN A CG  1 
ATOM   4501 C  CD  A GLN A 1 601 ? -26.320 -72.516 -13.236 0.25 29.78  ? 864  GLN A CD  1 
ATOM   4502 C  CD  B GLN A 1 601 ? -27.537 -72.191 -11.892 0.25 28.98  ? 864  GLN A CD  1 
ATOM   4503 O  OE1 A GLN A 1 601 ? -27.249 -71.989 -12.625 0.25 31.74  ? 864  GLN A OE1 1 
ATOM   4504 O  OE1 B GLN A 1 601 ? -27.281 -71.826 -13.041 0.25 29.15  ? 864  GLN A OE1 1 
ATOM   4505 N  NE2 A GLN A 1 601 ? -26.129 -72.336 -14.535 0.25 31.47  ? 864  GLN A NE2 1 
ATOM   4506 N  NE2 B GLN A 1 601 ? -28.449 -71.590 -11.145 0.25 29.99  ? 864  GLN A NE2 1 
ATOM   4507 N  N   . THR A 1 602 ? -24.185 -72.291 -8.173  1.00 26.56  ? 865  THR A N   1 
ATOM   4508 C  CA  . THR A 1 602 ? -24.300 -72.104 -6.703  1.00 27.88  ? 865  THR A CA  1 
ATOM   4509 C  C   . THR A 1 602 ? -24.275 -70.609 -6.343  1.00 27.82  ? 865  THR A C   1 
ATOM   4510 O  O   . THR A 1 602 ? -24.984 -70.194 -5.429  1.00 25.62  ? 865  THR A O   1 
ATOM   4511 C  CB  . THR A 1 602 ? -23.184 -72.852 -5.964  1.00 31.88  ? 865  THR A CB  1 
ATOM   4512 O  OG1 . THR A 1 602 ? -23.341 -74.205 -6.416  1.00 38.58  ? 865  THR A OG1 1 
ATOM   4513 C  CG2 . THR A 1 602 ? -23.324 -72.716 -4.475  1.00 36.86  ? 865  THR A CG2 1 
ATOM   4514 N  N   . ALA A 1 603 ? -23.461 -69.807 -7.016  1.00 24.74  ? 866  ALA A N   1 
ATOM   4515 C  CA  . ALA A 1 603 ? -23.358 -68.356 -6.751  1.00 23.84  ? 866  ALA A CA  1 
ATOM   4516 C  C   . ALA A 1 603 ? -24.626 -67.694 -7.242  1.00 20.19  ? 866  ALA A C   1 
ATOM   4517 O  O   . ALA A 1 603 ? -25.227 -66.844 -6.533  1.00 22.83  ? 866  ALA A O   1 
ATOM   4518 C  CB  . ALA A 1 603 ? -22.179 -67.774 -7.474  1.00 24.29  ? 866  ALA A CB  1 
ATOM   4519 N  N   . ILE A 1 604 ? -25.057 -68.106 -8.424  1.00 23.29  ? 867  ILE A N   1 
ATOM   4520 C  CA  . ILE A 1 604 ? -26.295 -67.537 -9.047  1.00 22.49  ? 867  ILE A CA  1 
ATOM   4521 C  C   . ILE A 1 604 ? -27.457 -67.812 -8.081  1.00 23.90  ? 867  ILE A C   1 
ATOM   4522 O  O   . ILE A 1 604 ? -28.251 -66.904 -7.800  1.00 23.69  ? 867  ILE A O   1 
ATOM   4523 C  CB  . ILE A 1 604 ? -26.499 -68.129 -10.444 1.00 23.48  ? 867  ILE A CB  1 
ATOM   4524 C  CG1 . ILE A 1 604 ? -25.475 -67.564 -11.434 1.00 22.78  ? 867  ILE A CG1 1 
ATOM   4525 C  CG2 . ILE A 1 604 ? -27.921 -67.896 -10.941 1.00 23.86  ? 867  ILE A CG2 1 
ATOM   4526 C  CD1 . ILE A 1 604 ? -25.425 -68.331 -12.700 1.00 24.97  ? 867  ILE A CD1 1 
ATOM   4527 N  N   . ASN A 1 605 ? -27.510 -69.036 -7.544  1.00 24.37  ? 868  ASN A N   1 
ATOM   4528 C  CA  . ASN A 1 605 ? -28.631 -69.463 -6.655  1.00 26.99  ? 868  ASN A CA  1 
ATOM   4529 C  C   . ASN A 1 605 ? -28.539 -68.700 -5.324  1.00 24.79  ? 868  ASN A C   1 
ATOM   4530 O  O   . ASN A 1 605 ? -29.585 -68.386 -4.767  1.00 24.05  ? 868  ASN A O   1 
ATOM   4531 C  CB  . ASN A 1 605 ? -28.629 -70.982 -6.479  1.00 28.92  ? 868  ASN A CB  1 
ATOM   4532 C  CG  . ASN A 1 605 ? -29.087 -71.730 -7.714  1.00 33.13  ? 868  ASN A CG  1 
ATOM   4533 O  OD1 . ASN A 1 605 ? -29.743 -71.195 -8.608  1.00 38.96  ? 868  ASN A OD1 1 
ATOM   4534 N  ND2 . ASN A 1 605 ? -28.754 -72.998 -7.776  1.00 40.05  ? 868  ASN A ND2 1 
ATOM   4535 N  N   . GLN A 1 606 ? -27.342 -68.352 -4.840  1.00 24.80  ? 869  GLN A N   1 
ATOM   4536 C  CA  . GLN A 1 606 ? -27.239 -67.542 -3.614  1.00 22.88  ? 869  GLN A CA  1 
ATOM   4537 C  C   . GLN A 1 606 ? -27.916 -66.195 -3.826  1.00 22.66  ? 869  GLN A C   1 
ATOM   4538 O  O   . GLN A 1 606 ? -28.696 -65.744 -2.933  1.00 25.49  ? 869  GLN A O   1 
ATOM   4539 C  CB  . GLN A 1 606 ? -25.796 -67.365 -3.148  1.00 24.65  ? 869  GLN A CB  1 
ATOM   4540 C  CG  . GLN A 1 606 ? -25.708 -66.524 -1.884  1.00 29.07  ? 869  GLN A CG  1 
ATOM   4541 C  CD  . GLN A 1 606 ? -24.292 -66.237 -1.419  1.00 35.02  ? 869  GLN A CD  1 
ATOM   4542 O  OE1 . GLN A 1 606 ? -23.355 -66.161 -2.230  1.00 32.37  ? 869  GLN A OE1 1 
ATOM   4543 N  NE2 . GLN A 1 606 ? -24.141 -66.027 -0.118  1.00 30.82  ? 869  GLN A NE2 1 
ATOM   4544 N  N   . VAL A 1 607 ? -27.639 -65.523 -4.942  1.00 21.15  ? 870  VAL A N   1 
ATOM   4545 C  CA  . VAL A 1 607 ? -28.223 -64.193 -5.204  1.00 20.56  ? 870  VAL A CA  1 
ATOM   4546 C  C   . VAL A 1 607 ? -29.749 -64.329 -5.451  1.00 20.19  ? 870  VAL A C   1 
ATOM   4547 O  O   . VAL A 1 607 ? -30.519 -63.548 -4.849  1.00 21.19  ? 870  VAL A O   1 
ATOM   4548 C  CB  . VAL A 1 607 ? -27.487 -63.527 -6.374  1.00 21.83  ? 870  VAL A CB  1 
ATOM   4549 C  CG1 . VAL A 1 607 ? -28.193 -62.273 -6.794  1.00 21.62  ? 870  VAL A CG1 1 
ATOM   4550 C  CG2 . VAL A 1 607 ? -26.037 -63.269 -5.965  1.00 20.92  ? 870  VAL A CG2 1 
ATOM   4551 N  N   . ARG A 1 608 ? -30.172 -65.360 -6.199  1.00 21.24  ? 871  ARG A N   1 
ATOM   4552 C  CA  . ARG A 1 608 ? -31.629 -65.579 -6.436  1.00 23.77  ? 871  ARG A CA  1 
ATOM   4553 C  C   . ARG A 1 608 ? -32.346 -65.794 -5.101  1.00 25.19  ? 871  ARG A C   1 
ATOM   4554 O  O   . ARG A 1 608 ? -33.442 -65.243 -4.940  1.00 27.23  ? 871  ARG A O   1 
ATOM   4555 C  CB  . ARG A 1 608 ? -31.852 -66.786 -7.349  1.00 22.57  ? 871  ARG A CB  1 
ATOM   4556 C  CG  . ARG A 1 608 ? -31.481 -66.518 -8.799  1.00 24.32  ? 871  ARG A CG  1 
ATOM   4557 C  CD  . ARG A 1 608 ? -31.734 -67.781 -9.577  1.00 25.39  ? 871  ARG A CD  1 
ATOM   4558 N  NE  . ARG A 1 608 ? -31.591 -67.616 -10.993 1.00 26.29  ? 871  ARG A NE  1 
ATOM   4559 C  CZ  . ARG A 1 608 ? -31.526 -68.621 -11.848 1.00 31.57  ? 871  ARG A CZ  1 
ATOM   4560 N  NH1 . ARG A 1 608 ? -31.608 -69.880 -11.425 1.00 37.96  ? 871  ARG A NH1 1 
ATOM   4561 N  NH2 . ARG A 1 608 ? -31.364 -68.369 -13.123 1.00 29.53  ? 871  ARG A NH2 1 
ATOM   4562 N  N   . SER A 1 609 ? -31.738 -66.525 -4.169  1.00 25.41  ? 872  SER A N   1 
ATOM   4563 C  CA  . SER A 1 609 ? -32.349 -66.757 -2.838  1.00 27.06  ? 872  SER A CA  1 
ATOM   4564 C  C   . SER A 1 609 ? -32.487 -65.437 -2.076  1.00 25.72  ? 872  SER A C   1 
ATOM   4565 O  O   . SER A 1 609 ? -33.414 -65.325 -1.265  1.00 22.93  ? 872  SER A O   1 
ATOM   4566 C  CB  . SER A 1 609 ? -31.622 -67.801 -2.042  1.00 25.72  ? 872  SER A CB  1 
ATOM   4567 O  OG  . SER A 1 609 ? -31.592 -69.049 -2.745  1.00 28.00  ? 872  SER A OG  1 
ATOM   4568 N  N   . LEU A 1 610 ? -31.539 -64.499 -2.180  1.00 22.44  ? 873  LEU A N   1 
ATOM   4569 C  CA  . LEU A 1 610 ? -31.615 -63.196 -1.476  1.00 22.62  ? 873  LEU A CA  1 
ATOM   4570 C  C   . LEU A 1 610 ? -32.717 -62.326 -2.105  1.00 25.42  ? 873  LEU A C   1 
ATOM   4571 O  O   . LEU A 1 610 ? -33.478 -61.654 -1.373  1.00 22.83  ? 873  LEU A O   1 
ATOM   4572 C  CB  . LEU A 1 610 ? -30.231 -62.539 -1.553  1.00 23.23  ? 873  LEU A CB  1 
ATOM   4573 C  CG  . LEU A 1 610 ? -29.146 -63.214 -0.742  1.00 23.88  ? 873  LEU A CG  1 
ATOM   4574 C  CD1 . LEU A 1 610 ? -27.769 -62.609 -1.067  1.00 25.66  ? 873  LEU A CD1 1 
ATOM   4575 C  CD2 . LEU A 1 610 ? -29.416 -63.143 0.763   1.00 25.55  ? 873  LEU A CD2 1 
ATOM   4576 N  N   . ILE A 1 611 ? -32.805 -62.307 -3.423  1.00 24.65  ? 874  ILE A N   1 
ATOM   4577 C  CA  . ILE A 1 611 ? -33.786 -61.431 -4.129  1.00 25.00  ? 874  ILE A CA  1 
ATOM   4578 C  C   . ILE A 1 611 ? -35.194 -62.029 -3.920  1.00 27.86  ? 874  ILE A C   1 
ATOM   4579 O  O   . ILE A 1 611 ? -36.151 -61.244 -3.719  1.00 27.81  ? 874  ILE A O   1 
ATOM   4580 C  CB  . ILE A 1 611 ? -33.384 -61.271 -5.614  1.00 26.49  ? 874  ILE A CB  1 
ATOM   4581 C  CG1 . ILE A 1 611 ? -32.072 -60.496 -5.753  1.00 25.76  ? 874  ILE A CG1 1 
ATOM   4582 C  CG2 . ILE A 1 611 ? -34.485 -60.568 -6.418  1.00 27.27  ? 874  ILE A CG2 1 
ATOM   4583 C  CD1 . ILE A 1 611 ? -31.555 -60.336 -7.159  1.00 25.52  ? 874  ILE A CD1 1 
ATOM   4584 N  N   . GLY A 1 612 ? -35.327 -63.352 -3.939  1.00 25.81  ? 875  GLY A N   1 
ATOM   4585 C  CA  . GLY A 1 612 ? -36.593 -64.067 -3.620  1.00 30.77  ? 875  GLY A CA  1 
ATOM   4586 C  C   . GLY A 1 612 ? -37.243 -64.704 -4.844  1.00 31.55  ? 875  GLY A C   1 
ATOM   4587 O  O   . GLY A 1 612 ? -36.626 -64.815 -5.901  1.00 28.80  ? 875  GLY A O   1 
ATOM   4588 N  N   . ASN A 1 613 ? -38.494 -65.134 -4.664  0.34 30.33  ? 876  ASN A N   1 
ATOM   4589 C  CA  . ASN A 1 613 ? -39.312 -65.803 -5.707  0.34 29.76  ? 876  ASN A CA  1 
ATOM   4590 C  C   . ASN A 1 613 ? -39.644 -64.788 -6.802  0.34 30.46  ? 876  ASN A C   1 
ATOM   4591 O  O   . ASN A 1 613 ? -40.588 -63.989 -6.618  0.34 29.31  ? 876  ASN A O   1 
ATOM   4592 C  CB  . ASN A 1 613 ? -40.597 -66.395 -5.124  0.34 31.42  ? 876  ASN A CB  1 
ATOM   4593 C  CG  . ASN A 1 613 ? -41.139 -67.535 -5.956  0.34 31.50  ? 876  ASN A CG  1 
ATOM   4594 O  OD1 . ASN A 1 613 ? -40.372 -68.347 -6.480  0.34 30.05  ? 876  ASN A OD1 1 
ATOM   4595 N  ND2 . ASN A 1 613 ? -42.458 -67.621 -6.050  0.34 32.76  ? 876  ASN A ND2 1 
ATOM   4596 N  N   . GLU A 1 614 ? -38.874 -64.802 -7.888  1.00 28.80  ? 877  GLU A N   1 
ATOM   4597 C  CA  . GLU A 1 614 ? -39.091 -63.916 -9.034  1.00 26.40  ? 877  GLU A CA  1 
ATOM   4598 C  C   . GLU A 1 614 ? -38.916 -64.779 -10.290 1.00 25.37  ? 877  GLU A C   1 
ATOM   4599 O  O   . GLU A 1 614 ? -38.588 -65.985 -10.161 1.00 28.81  ? 877  GLU A O   1 
ATOM   4600 C  CB  . GLU A 1 614 ? -38.035 -62.803 -8.976  1.00 26.28  ? 877  GLU A CB  1 
ATOM   4601 C  CG  . GLU A 1 614 ? -38.200 -61.846 -7.816  1.00 26.48  ? 877  GLU A CG  1 
ATOM   4602 C  CD  . GLU A 1 614 ? -39.424 -60.921 -7.817  1.00 29.20  ? 877  GLU A CD  1 
ATOM   4603 O  OE1 . GLU A 1 614 ? -40.040 -60.688 -8.874  1.00 27.12  ? 877  GLU A OE1 1 
ATOM   4604 O  OE2 . GLU A 1 614 ? -39.644 -60.310 -6.779  1.00 31.00  ? 877  GLU A OE2 1 
ATOM   4605 N  N   . GLU A 1 615 ? -39.144 -64.212 -11.462 1.00 29.23  ? 878  GLU A N   1 
ATOM   4606 C  CA  . GLU A 1 615 ? -38.935 -64.948 -12.743 1.00 31.31  ? 878  GLU A CA  1 
ATOM   4607 C  C   . GLU A 1 615 ? -37.479 -64.683 -13.175 1.00 28.06  ? 878  GLU A C   1 
ATOM   4608 O  O   . GLU A 1 615 ? -37.161 -63.493 -13.441 1.00 29.48  ? 878  GLU A O   1 
ATOM   4609 C  CB  . GLU A 1 615 ? -39.900 -64.484 -13.848 1.00 35.87  ? 878  GLU A CB  1 
ATOM   4610 C  CG  . GLU A 1 615 ? -39.640 -65.205 -15.179 1.00 47.76  ? 878  GLU A CG  1 
ATOM   4611 C  CD  . GLU A 1 615 ? -40.510 -64.842 -16.388 1.00 60.46  ? 878  GLU A CD  1 
ATOM   4612 O  OE1 . GLU A 1 615 ? -41.425 -63.976 -16.254 1.00 53.53  ? 878  GLU A OE1 1 
ATOM   4613 O  OE2 . GLU A 1 615 ? -40.279 -65.436 -17.482 1.00 68.71  ? 878  GLU A OE2 1 
ATOM   4614 N  N   . TYR A 1 616 ? -36.697 -65.744 -13.315 1.00 29.73  ? 879  TYR A N   1 
ATOM   4615 C  CA  . TYR A 1 616 ? -35.274 -65.747 -13.765 1.00 30.11  ? 879  TYR A CA  1 
ATOM   4616 C  C   . TYR A 1 616 ? -35.125 -66.574 -15.038 1.00 33.41  ? 879  TYR A C   1 
ATOM   4617 O  O   . TYR A 1 616 ? -35.907 -67.508 -15.293 1.00 29.03  ? 879  TYR A O   1 
ATOM   4618 C  CB  . TYR A 1 616 ? -34.387 -66.325 -12.669 1.00 30.60  ? 879  TYR A CB  1 
ATOM   4619 C  CG  . TYR A 1 616 ? -34.483 -65.634 -11.334 1.00 26.74  ? 879  TYR A CG  1 
ATOM   4620 C  CD1 . TYR A 1 616 ? -33.732 -64.511 -11.037 1.00 23.48  ? 879  TYR A CD1 1 
ATOM   4621 C  CD2 . TYR A 1 616 ? -35.268 -66.165 -10.323 1.00 27.62  ? 879  TYR A CD2 1 
ATOM   4622 C  CE1 . TYR A 1 616 ? -33.777 -63.920 -9.780  1.00 26.45  ? 879  TYR A CE1 1 
ATOM   4623 C  CE2 . TYR A 1 616 ? -35.339 -65.585 -9.059  1.00 24.07  ? 879  TYR A CE2 1 
ATOM   4624 C  CZ  . TYR A 1 616 ? -34.582 -64.465 -8.780  1.00 26.87  ? 879  TYR A CZ  1 
ATOM   4625 O  OH  . TYR A 1 616 ? -34.671 -63.905 -7.527  1.00 27.21  ? 879  TYR A OH  1 
ATOM   4626 N  N   . THR A 1 617 ? -34.127 -66.207 -15.853 1.00 31.54  ? 880  THR A N   1 
ATOM   4627 C  CA  . THR A 1 617 ? -33.660 -66.969 -17.037 1.00 32.29  ? 880  THR A CA  1 
ATOM   4628 C  C   . THR A 1 617 ? -32.241 -67.479 -16.767 1.00 31.51  ? 880  THR A C   1 
ATOM   4629 O  O   . THR A 1 617 ? -31.452 -66.714 -16.170 1.00 27.45  ? 880  THR A O   1 
ATOM   4630 C  CB  . THR A 1 617 ? -33.634 -66.036 -18.245 1.00 35.86  ? 880  THR A CB  1 
ATOM   4631 O  OG1 . THR A 1 617 ? -34.929 -65.447 -18.323 1.00 35.68  ? 880  THR A OG1 1 
ATOM   4632 C  CG2 . THR A 1 617 ? -33.266 -66.718 -19.549 1.00 36.89  ? 880  THR A CG2 1 
ATOM   4633 N  N   . ASP A 1 618 ? -31.939 -68.713 -17.145 1.00 30.31  ? 881  ASP A N   1 
ATOM   4634 C  CA  . ASP A 1 618 ? -30.549 -69.228 -17.145 1.00 33.01  ? 881  ASP A CA  1 
ATOM   4635 C  C   . ASP A 1 618 ? -29.858 -68.820 -18.455 1.00 34.72  ? 881  ASP A C   1 
ATOM   4636 O  O   . ASP A 1 618 ? -30.157 -69.437 -19.505 1.00 29.54  ? 881  ASP A O   1 
ATOM   4637 C  CB  . ASP A 1 618 ? -30.540 -70.744 -16.931 1.00 36.93  ? 881  ASP A CB  1 
ATOM   4638 C  CG  . ASP A 1 618 ? -29.149 -71.362 -16.844 1.00 42.35  ? 881  ASP A CG  1 
ATOM   4639 O  OD1 . ASP A 1 618 ? -28.119 -70.609 -16.574 1.00 35.42  ? 881  ASP A OD1 1 
ATOM   4640 O  OD2 . ASP A 1 618 ? -29.098 -72.589 -17.038 1.00 42.54  ? 881  ASP A OD2 1 
ATOM   4641 N  N   . TYR A 1 619 ? -28.885 -67.892 -18.393 1.00 30.76  ? 882  TYR A N   1 
ATOM   4642 C  CA  . TYR A 1 619 ? -28.071 -67.528 -19.580 1.00 28.95  ? 882  TYR A CA  1 
ATOM   4643 C  C   . TYR A 1 619 ? -26.779 -68.339 -19.640 1.00 30.31  ? 882  TYR A C   1 
ATOM   4644 O  O   . TYR A 1 619 ? -26.078 -68.182 -20.632 1.00 30.54  ? 882  TYR A O   1 
ATOM   4645 C  CB  . TYR A 1 619 ? -27.757 -66.033 -19.591 1.00 29.67  ? 882  TYR A CB  1 
ATOM   4646 C  CG  . TYR A 1 619 ? -28.989 -65.182 -19.760 1.00 34.18  ? 882  TYR A CG  1 
ATOM   4647 C  CD1 . TYR A 1 619 ? -29.639 -65.094 -20.985 1.00 36.03  ? 882  TYR A CD1 1 
ATOM   4648 C  CD2 . TYR A 1 619 ? -29.535 -64.505 -18.690 1.00 27.44  ? 882  TYR A CD2 1 
ATOM   4649 C  CE1 . TYR A 1 619 ? -30.785 -64.325 -21.151 1.00 34.93  ? 882  TYR A CE1 1 
ATOM   4650 C  CE2 . TYR A 1 619 ? -30.693 -63.744 -18.830 1.00 30.57  ? 882  TYR A CE2 1 
ATOM   4651 C  CZ  . TYR A 1 619 ? -31.295 -63.620 -20.071 1.00 34.94  ? 882  TYR A CZ  1 
ATOM   4652 O  OH  . TYR A 1 619 ? -32.398 -62.825 -20.213 1.00 36.45  ? 882  TYR A OH  1 
ATOM   4653 N  N   . MET A 1 620 ? -26.441 -69.168 -18.657 1.00 32.25  ? 883  MET A N   1 
ATOM   4654 C  CA  . MET A 1 620 ? -25.135 -69.873 -18.707 1.00 31.20  ? 883  MET A CA  1 
ATOM   4655 C  C   . MET A 1 620 ? -25.024 -70.820 -19.927 1.00 36.56  ? 883  MET A C   1 
ATOM   4656 O  O   . MET A 1 620 ? -23.954 -70.852 -20.554 1.00 38.60  ? 883  MET A O   1 
ATOM   4657 C  CB  . MET A 1 620 ? -24.773 -70.571 -17.395 1.00 31.90  ? 883  MET A CB  1 
ATOM   4658 C  CG  . MET A 1 620 ? -24.845 -69.683 -16.129 1.00 31.55  ? 883  MET A CG  1 
ATOM   4659 S  SD  . MET A 1 620 ? -24.060 -68.037 -16.328 1.00 30.40  ? 883  MET A SD  1 
ATOM   4660 C  CE  . MET A 1 620 ? -22.350 -68.490 -16.620 1.00 29.73  ? 883  MET A CE  1 
ATOM   4661 N  N   . PRO A 1 621 ? -26.053 -71.571 -20.404 1.00 38.84  ? 884  PRO A N   1 
ATOM   4662 C  CA  . PRO A 1 621 ? -25.865 -72.447 -21.575 1.00 41.26  ? 884  PRO A CA  1 
ATOM   4663 C  C   . PRO A 1 621 ? -25.691 -71.756 -22.942 1.00 44.34  ? 884  PRO A C   1 
ATOM   4664 O  O   . PRO A 1 621 ? -25.512 -72.484 -23.923 1.00 47.81  ? 884  PRO A O   1 
ATOM   4665 C  CB  . PRO A 1 621 ? -27.143 -73.331 -21.600 1.00 42.41  ? 884  PRO A CB  1 
ATOM   4666 C  CG  . PRO A 1 621 ? -27.738 -73.198 -20.207 1.00 43.34  ? 884  PRO A CG  1 
ATOM   4667 C  CD  . PRO A 1 621 ? -27.379 -71.778 -19.784 1.00 42.23  ? 884  PRO A CD  1 
ATOM   4668 N  N   . SER A 1 622 ? -25.672 -70.411 -22.991 1.00 40.69  ? 885  SER A N   1 
ATOM   4669 C  CA  . SER A 1 622 ? -25.200 -69.620 -24.166 1.00 42.05  ? 885  SER A CA  1 
ATOM   4670 C  C   . SER A 1 622 ? -23.674 -69.761 -24.322 1.00 43.68  ? 885  SER A C   1 
ATOM   4671 O  O   . SER A 1 622 ? -23.155 -69.378 -25.406 1.00 41.79  ? 885  SER A O   1 
ATOM   4672 C  CB  . SER A 1 622 ? -25.592 -68.166 -24.091 1.00 42.79  ? 885  SER A CB  1 
ATOM   4673 O  OG  . SER A 1 622 ? -24.834 -67.458 -23.106 1.00 34.52  ? 885  SER A OG  1 
ATOM   4674 N  N   . MET A 1 623 ? -22.972 -70.265 -23.293 1.00 36.44  ? 886  MET A N   1 
ATOM   4675 C  CA  . MET A 1 623 ? -21.516 -70.548 -23.366 1.00 41.88  ? 886  MET A CA  1 
ATOM   4676 C  C   . MET A 1 623 ? -21.300 -72.051 -23.598 1.00 46.46  ? 886  MET A C   1 
ATOM   4677 O  O   . MET A 1 623 ? -22.004 -72.871 -22.965 1.00 41.71  ? 886  MET A O   1 
ATOM   4678 C  CB  . MET A 1 623 ? -20.810 -70.146 -22.065 1.00 45.46  ? 886  MET A CB  1 
ATOM   4679 C  CG  . MET A 1 623 ? -21.354 -68.894 -21.462 1.00 44.98  ? 886  MET A CG  1 
ATOM   4680 S  SD  . MET A 1 623 ? -20.367 -68.318 -20.055 1.00 42.57  ? 886  MET A SD  1 
ATOM   4681 C  CE  . MET A 1 623 ? -18.895 -67.780 -20.895 1.00 42.19  ? 886  MET A CE  1 
ATOM   4682 N  N   . LYS A 1 624 ? -20.329 -72.393 -24.450 0.64 52.55  ? 887  LYS A N   1 
ATOM   4683 C  CA  . LYS A 1 624 ? -19.984 -73.786 -24.855 0.64 59.62  ? 887  LYS A CA  1 
ATOM   4684 C  C   . LYS A 1 624 ? -19.927 -74.716 -23.632 0.64 59.80  ? 887  LYS A C   1 
ATOM   4685 O  O   . LYS A 1 624 ? -20.585 -75.774 -23.674 0.64 57.37  ? 887  LYS A O   1 
ATOM   4686 C  CB  . LYS A 1 624 ? -18.650 -73.788 -25.612 0.64 65.62  ? 887  LYS A CB  1 
ATOM   4687 C  CG  . LYS A 1 624 ? -18.170 -75.153 -26.096 0.64 73.00  ? 887  LYS A CG  1 
ATOM   4688 C  CD  . LYS A 1 624 ? -17.219 -75.075 -27.282 0.64 77.45  ? 887  LYS A CD  1 
ATOM   4689 C  CE  . LYS A 1 624 ? -16.290 -76.269 -27.395 0.64 80.24  ? 887  LYS A CE  1 
ATOM   4690 N  NZ  . LYS A 1 624 ? -15.244 -76.257 -26.343 0.64 80.53  ? 887  LYS A NZ  1 
ATOM   4691 N  N   . ARG A 1 625 ? -19.189 -74.335 -22.580 0.64 63.56  ? 888  ARG A N   1 
ATOM   4692 C  CA  . ARG A 1 625 ? -18.803 -75.233 -21.450 0.64 64.58  ? 888  ARG A CA  1 
ATOM   4693 C  C   . ARG A 1 625 ? -20.004 -75.546 -20.542 0.64 62.86  ? 888  ARG A C   1 
ATOM   4694 O  O   . ARG A 1 625 ? -19.898 -76.498 -19.750 0.64 58.10  ? 888  ARG A O   1 
ATOM   4695 C  CB  . ARG A 1 625 ? -17.677 -74.614 -20.614 0.64 67.15  ? 888  ARG A CB  1 
ATOM   4696 C  CG  . ARG A 1 625 ? -18.120 -73.478 -19.699 0.64 67.99  ? 888  ARG A CG  1 
ATOM   4697 C  CD  . ARG A 1 625 ? -17.136 -73.210 -18.571 0.64 67.19  ? 888  ARG A CD  1 
ATOM   4698 N  NE  . ARG A 1 625 ? -17.170 -74.247 -17.546 0.64 68.26  ? 888  ARG A NE  1 
ATOM   4699 C  CZ  . ARG A 1 625 ? -16.197 -74.478 -16.673 0.64 62.89  ? 888  ARG A CZ  1 
ATOM   4700 N  NH1 . ARG A 1 625 ? -15.096 -73.745 -16.698 0.64 65.87  ? 888  ARG A NH1 1 
ATOM   4701 N  NH2 . ARG A 1 625 ? -16.323 -75.447 -15.785 0.64 60.47  ? 888  ARG A NH2 1 
ATOM   4702 N  N   . PHE A 1 626 ? -21.088 -74.766 -20.616 0.50 62.28  ? 889  PHE A N   1 
ATOM   4703 C  CA  . PHE A 1 626 ? -22.313 -74.967 -19.794 0.50 63.17  ? 889  PHE A CA  1 
ATOM   4704 C  C   . PHE A 1 626 ? -23.422 -75.543 -20.680 0.50 68.97  ? 889  PHE A C   1 
ATOM   4705 O  O   . PHE A 1 626 ? -24.490 -75.930 -20.161 0.50 65.66  ? 889  PHE A O   1 
ATOM   4706 C  CB  . PHE A 1 626 ? -22.745 -73.663 -19.116 0.50 58.36  ? 889  PHE A CB  1 
ATOM   4707 C  CG  . PHE A 1 626 ? -21.724 -73.086 -18.170 0.50 57.04  ? 889  PHE A CG  1 
ATOM   4708 C  CD1 . PHE A 1 626 ? -21.376 -73.751 -17.005 0.50 57.20  ? 889  PHE A CD1 1 
ATOM   4709 C  CD2 . PHE A 1 626 ? -21.098 -71.882 -18.451 0.50 54.17  ? 889  PHE A CD2 1 
ATOM   4710 C  CE1 . PHE A 1 626 ? -20.429 -73.222 -16.141 0.50 57.23  ? 889  PHE A CE1 1 
ATOM   4711 C  CE2 . PHE A 1 626 ? -20.153 -71.353 -17.586 0.50 53.95  ? 889  PHE A CE2 1 
ATOM   4712 C  CZ  . PHE A 1 626 ? -19.819 -72.024 -16.432 0.50 53.52  ? 889  PHE A CZ  1 
ATOM   4713 N  N   . ARG A 1 627 ? -23.178 -75.591 -21.989 0.64 78.39  ? 890  ARG A N   1 
ATOM   4714 C  CA  . ARG A 1 627 ? -24.086 -76.250 -22.962 0.64 90.04  ? 890  ARG A CA  1 
ATOM   4715 C  C   . ARG A 1 627 ? -23.972 -77.763 -22.740 0.64 98.97  ? 890  ARG A C   1 
ATOM   4716 O  O   . ARG A 1 627 ? -23.214 -78.416 -23.483 0.64 105.78 ? 890  ARG A O   1 
ATOM   4717 C  CB  . ARG A 1 627 ? -23.744 -75.812 -24.391 0.64 90.45  ? 890  ARG A CB  1 
ATOM   4718 C  CG  . ARG A 1 627 ? -24.879 -75.994 -25.389 0.64 90.70  ? 890  ARG A CG  1 
ATOM   4719 C  CD  . ARG A 1 627 ? -24.614 -75.270 -26.695 0.64 91.98  ? 890  ARG A CD  1 
ATOM   4720 N  NE  . ARG A 1 627 ? -23.215 -75.356 -27.084 0.64 92.27  ? 890  ARG A NE  1 
ATOM   4721 C  CZ  . ARG A 1 627 ? -22.717 -76.246 -27.934 0.64 92.28  ? 890  ARG A CZ  1 
ATOM   4722 N  NH1 . ARG A 1 627 ? -23.510 -77.138 -28.502 0.64 94.69  ? 890  ARG A NH1 1 
ATOM   4723 N  NH2 . ARG A 1 627 ? -21.427 -76.239 -28.216 0.64 91.90  ? 890  ARG A NH2 1 
ATOM   4724 N  N   . ARG A 1 628 ? -24.670 -78.277 -21.719 0.64 106.37 ? 891  ARG A N   1 
ATOM   4725 C  CA  . ARG A 1 628 ? -24.643 -79.702 -21.289 0.64 108.11 ? 891  ARG A CA  1 
ATOM   4726 C  C   . ARG A 1 628 ? -23.208 -80.093 -20.916 0.64 106.39 ? 891  ARG A C   1 
ATOM   4727 O  O   . ARG A 1 628 ? -22.237 -79.571 -21.467 0.64 102.15 ? 891  ARG A O   1 
ATOM   4728 C  CB  . ARG A 1 628 ? -25.195 -80.601 -22.400 0.64 113.70 ? 891  ARG A CB  1 
ATOM   4729 C  CG  . ARG A 1 628 ? -26.636 -80.294 -22.781 0.64 117.10 ? 891  ARG A CG  1 
ATOM   4730 C  CD  . ARG A 1 628 ? -27.533 -80.292 -21.559 0.64 121.15 ? 891  ARG A CD  1 
ATOM   4731 N  NE  . ARG A 1 628 ? -27.257 -81.434 -20.700 0.64 125.38 ? 891  ARG A NE  1 
ATOM   4732 C  CZ  . ARG A 1 628 ? -27.862 -81.668 -19.542 0.64 129.03 ? 891  ARG A CZ  1 
ATOM   4733 N  NH1 . ARG A 1 628 ? -28.786 -80.834 -19.096 0.64 131.52 ? 891  ARG A NH1 1 
ATOM   4734 N  NH2 . ARG A 1 628 ? -27.540 -82.735 -18.833 0.64 127.12 ? 891  ARG A NH2 1 
HETATM 4735 ZN ZN  . ZN  B 2 .   ? -6.536  -55.534 -23.763 1.00 20.41  2 1001 ZN  A ZN  1 
HETATM 4736 ZN ZN  . ZN  C 2 .   ? -25.926 -14.774 -13.202 1.00 51.06  2 1002 ZN  A ZN  1 
HETATM 4737 O  O1  A MES D 3 .   ? -28.468 -57.831 0.493   0.25 29.24  ? 1003 MES A O1  1 
HETATM 4738 O  O1  B MES D 3 .   ? -28.176 -57.696 0.168   0.25 704.03 ? 1003 MES A O1  1 
HETATM 4739 C  C2  A MES D 3 .   ? -27.836 -58.220 1.703   0.25 27.04  ? 1003 MES A C2  1 
HETATM 4740 C  C2  B MES D 3 .   ? -27.486 -58.105 1.339   0.25 718.39 ? 1003 MES A C2  1 
HETATM 4741 C  C3  A MES D 3 .   ? -26.399 -57.769 1.733   0.25 26.54  ? 1003 MES A C3  1 
HETATM 4742 C  C3  B MES D 3 .   ? -25.993 -58.101 1.125   0.25 726.61 ? 1003 MES A C3  1 
HETATM 4743 N  N4  A MES D 3 .   ? -25.649 -58.359 0.583   0.25 23.71  ? 1003 MES A N4  1 
HETATM 4744 N  N4  B MES D 3 .   ? -25.636 -59.007 -0.010  0.25 733.79 ? 1003 MES A N4  1 
HETATM 4745 C  C5  A MES D 3 .   ? -26.351 -58.029 -0.696  0.25 26.52  ? 1003 MES A C5  1 
HETATM 4746 C  C5  B MES D 3 .   ? -26.416 -58.603 -1.219  0.25 711.83 ? 1003 MES A C5  1 
HETATM 4747 C  C6  A MES D 3 .   ? -27.813 -58.411 -0.627  0.25 27.83  ? 1003 MES A C6  1 
HETATM 4748 C  C6  B MES D 3 .   ? -27.889 -58.588 -0.898  0.25 695.45 ? 1003 MES A C6  1 
HETATM 4749 C  C7  A MES D 3 .   ? -24.210 -57.924 0.562   0.25 23.32  ? 1003 MES A C7  1 
HETATM 4750 C  C7  B MES D 3 .   ? -24.160 -59.016 -0.283  0.25 758.77 ? 1003 MES A C7  1 
HETATM 4751 C  C8  A MES D 3 .   ? -23.338 -58.896 -0.210  0.25 22.07  ? 1003 MES A C8  1 
HETATM 4752 C  C8  B MES D 3 .   ? -23.407 -57.919 0.441   0.25 780.64 ? 1003 MES A C8  1 
HETATM 4753 S  S   A MES D 3 .   ? -21.602 -58.855 0.231   0.25 20.40  ? 1003 MES A S   1 
HETATM 4754 S  S   B MES D 3 .   ? -21.647 -58.181 0.420   0.25 801.25 ? 1003 MES A S   1 
HETATM 4755 O  O1S A MES D 3 .   ? -21.314 -60.195 0.615   0.25 27.34  ? 1003 MES A O1S 1 
HETATM 4756 O  O1S B MES D 3 .   ? -21.457 -59.580 0.157   0.25 808.37 ? 1003 MES A O1S 1 
HETATM 4757 O  O2S A MES D 3 .   ? -20.941 -58.439 -0.970  0.25 21.62  ? 1003 MES A O2S 1 
HETATM 4758 O  O2S B MES D 3 .   ? -21.132 -57.346 -0.629  0.25 787.99 ? 1003 MES A O2S 1 
HETATM 4759 O  O3S A MES D 3 .   ? -21.427 -57.915 1.298   0.25 25.79  ? 1003 MES A O3S 1 
HETATM 4760 O  O3S B MES D 3 .   ? -21.170 -57.793 1.717   0.25 806.47 ? 1003 MES A O3S 1 
HETATM 4761 S  S   . DMS E 4 .   ? -26.927 -62.247 -21.038 1.00 44.12  ? 1004 DMS A S   1 
HETATM 4762 O  O   . DMS E 4 .   ? -26.697 -62.915 -22.458 1.00 45.23  ? 1004 DMS A O   1 
HETATM 4763 C  C1  . DMS E 4 .   ? -28.112 -60.991 -21.284 1.00 39.47  ? 1004 DMS A C1  1 
HETATM 4764 C  C2  . DMS E 4 .   ? -25.491 -61.189 -20.869 1.00 45.49  ? 1004 DMS A C2  1 
HETATM 4765 S  S   . DMS F 4 .   ? -15.977 -69.521 -28.963 1.00 107.21 ? 1005 DMS A S   1 
HETATM 4766 O  O   . DMS F 4 .   ? -16.431 -68.086 -29.139 1.00 74.61  ? 1005 DMS A O   1 
HETATM 4767 C  C1  . DMS F 4 .   ? -16.838 -70.154 -27.536 1.00 83.15  ? 1005 DMS A C1  1 
HETATM 4768 C  C2  . DMS F 4 .   ? -14.334 -69.476 -28.279 1.00 95.18  ? 1005 DMS A C2  1 
HETATM 4769 S  S   . DMS G 4 .   ? -23.086 -48.345 -16.159 1.00 57.05  ? 1006 DMS A S   1 
HETATM 4770 O  O   . DMS G 4 .   ? -24.139 -47.875 -17.126 1.00 59.88  ? 1006 DMS A O   1 
HETATM 4771 C  C1  . DMS G 4 .   ? -21.583 -47.834 -16.916 1.00 51.88  ? 1006 DMS A C1  1 
HETATM 4772 C  C2  . DMS G 4 .   ? -22.885 -50.037 -16.483 1.00 47.81  ? 1006 DMS A C2  1 
HETATM 4773 C  C1  . PEG H 5 .   ? -30.504 -47.505 -25.061 1.00 88.41  ? 1007 PEG A C1  1 
HETATM 4774 O  O1  . PEG H 5 .   ? -30.185 -47.262 -26.423 1.00 91.13  ? 1007 PEG A O1  1 
HETATM 4775 C  C2  . PEG H 5 .   ? -30.435 -46.259 -24.220 1.00 94.89  ? 1007 PEG A C2  1 
HETATM 4776 O  O2  . PEG H 5 .   ? -31.129 -46.452 -22.985 1.00 91.65  ? 1007 PEG A O2  1 
HETATM 4777 C  C3  . PEG H 5 .   ? -31.340 -45.256 -22.233 1.00 91.80  ? 1007 PEG A C3  1 
HETATM 4778 C  C4  . PEG H 5 .   ? -30.030 -44.663 -21.790 1.00 90.98  ? 1007 PEG A C4  1 
HETATM 4779 O  O4  . PEG H 5 .   ? -30.011 -44.337 -20.416 1.00 89.15  ? 1007 PEG A O4  1 
HETATM 4780 P  P   . PO4 I 6 .   ? -4.248  -39.712 -23.884 1.00 44.96  ? 1008 PO4 A P   1 
HETATM 4781 O  O1  . PO4 I 6 .   ? -2.828  -40.489 -23.256 1.00 30.89  ? 1008 PO4 A O1  1 
HETATM 4782 O  O2  . PO4 I 6 .   ? -3.808  -38.142 -24.485 1.00 33.64  ? 1008 PO4 A O2  1 
HETATM 4783 O  O3  . PO4 I 6 .   ? -4.855  -40.495 -25.248 1.00 33.26  ? 1008 PO4 A O3  1 
HETATM 4784 O  O4  . PO4 I 6 .   ? -5.273  -39.730 -22.818 1.00 62.08  ? 1008 PO4 A O4  1 
HETATM 4785 P  P   . PO4 J 6 .   ? -18.254 -9.645  -28.876 1.00 109.07 ? 1009 PO4 A P   1 
HETATM 4786 O  O1  . PO4 J 6 .   ? -17.840 -10.104 -27.454 1.00 72.53  ? 1009 PO4 A O1  1 
HETATM 4787 O  O2  . PO4 J 6 .   ? -16.989 -9.401  -29.701 1.00 90.96  ? 1009 PO4 A O2  1 
HETATM 4788 O  O3  . PO4 J 6 .   ? -19.110 -10.758 -29.551 1.00 81.63  ? 1009 PO4 A O3  1 
HETATM 4789 O  O4  . PO4 J 6 .   ? -19.071 -8.316  -28.811 1.00 84.77  ? 1009 PO4 A O4  1 
HETATM 4790 C  C1  . PEG K 5 .   ? -16.342 -43.857 -41.157 1.00 64.10  ? 1010 PEG A C1  1 
HETATM 4791 O  O1  . PEG K 5 .   ? -17.694 -44.226 -40.943 1.00 57.54  ? 1010 PEG A O1  1 
HETATM 4792 C  C2  . PEG K 5 .   ? -15.739 -44.584 -42.302 1.00 63.66  ? 1010 PEG A C2  1 
HETATM 4793 O  O2  . PEG K 5 .   ? -16.325 -45.879 -42.395 1.00 66.80  ? 1010 PEG A O2  1 
HETATM 4794 C  C3  . PEG K 5 .   ? -16.312 -46.420 -43.712 1.00 71.06  ? 1010 PEG A C3  1 
HETATM 4795 C  C4  . PEG K 5 .   ? -15.119 -47.305 -43.897 1.00 76.69  ? 1010 PEG A C4  1 
HETATM 4796 O  O4  . PEG K 5 .   ? -15.480 -48.601 -44.359 1.00 72.98  ? 1010 PEG A O4  1 
HETATM 4797 N  N1  A B1A L 7 .   ? -11.884 -70.709 -21.471 0.37 41.03  ? 1011 B1A A N1  1 
HETATM 4798 N  N1  B B1A L 7 .   ? -2.041  -69.648 -20.740 0.33 30.88  ? 1011 B1A A N1  1 
HETATM 4799 C  C4  A B1A L 7 .   ? -9.466  -71.077 -21.668 0.37 39.30  ? 1011 B1A A C4  1 
HETATM 4800 C  C4  B B1A L 7 .   ? -4.404  -69.488 -20.361 0.33 29.03  ? 1011 B1A A C4  1 
HETATM 4801 C  C5  A B1A L 7 .   ? -8.251  -71.354 -21.069 0.37 44.41  ? 1011 B1A A C5  1 
HETATM 4802 C  C5  B B1A L 7 .   ? -5.611  -70.021 -19.950 0.33 28.69  ? 1011 B1A A C5  1 
HETATM 4803 C  C6  A B1A L 7 .   ? -8.168  -71.515 -19.693 0.37 43.14  ? 1011 B1A A C6  1 
HETATM 4804 C  C6  B B1A L 7 .   ? -5.682  -71.326 -19.486 0.33 29.47  ? 1011 B1A A C6  1 
HETATM 4805 C  C7  A B1A L 7 .   ? -9.318  -71.396 -18.925 0.37 43.60  ? 1011 B1A A C7  1 
HETATM 4806 C  C7  B B1A L 7 .   ? -4.524  -72.091 -19.436 0.33 31.57  ? 1011 B1A A C7  1 
HETATM 4807 C  C8  A B1A L 7 .   ? -10.532 -71.117 -19.524 0.37 43.81  ? 1011 B1A A C8  1 
HETATM 4808 C  C8  B B1A L 7 .   ? -3.315  -71.558 -19.844 0.33 31.31  ? 1011 B1A A C8  1 
HETATM 4809 C  C10 A B1A L 7 .   ? -5.564  -70.021 -20.056 0.37 47.30  ? 1011 B1A A C10 1 
HETATM 4810 C  C10 B B1A L 7 .   ? -9.302  -71.512 -18.816 0.33 32.46  ? 1011 B1A A C10 1 
HETATM 4811 C  C13 A B1A L 7 .   ? -3.307  -71.578 -19.745 0.37 46.09  ? 1011 B1A A C13 1 
HETATM 4812 C  C13 B B1A L 7 .   ? -9.580  -70.937 -21.502 0.33 30.44  ? 1011 B1A A C13 1 
HETATM 4813 C  C1  A B1A L 7 .   ? -13.700 -70.436 -23.025 0.37 35.79  ? 1011 B1A A C1  1 
HETATM 4814 C  C1  B B1A L 7 .   ? 0.308   -69.162 -20.904 0.33 28.75  ? 1011 B1A A C1  1 
HETATM 4815 C  C2  A B1A L 7 .   ? -12.228 -70.566 -22.775 0.37 36.12  ? 1011 B1A A C2  1 
HETATM 4816 C  C2  B B1A L 7 .   ? -0.792  -70.172 -20.808 0.33 29.92  ? 1011 B1A A C2  1 
HETATM 4817 O  O1  A B1A L 7 .   ? -11.410 -70.551 -23.690 0.37 32.59  ? 1011 B1A A O1  1 
HETATM 4818 O  O1  B B1A L 7 .   ? -0.568  -71.379 -20.810 0.33 26.12  ? 1011 B1A A O1  1 
HETATM 4819 C  C3  A B1A L 7 .   ? -10.616 -70.962 -20.901 0.37 43.11  ? 1011 B1A A C3  1 
HETATM 4820 C  C3  B B1A L 7 .   ? -3.246  -70.251 -20.309 0.33 30.84  ? 1011 B1A A C3  1 
HETATM 4821 N  N2  A B1A L 7 .   ? -6.930  -71.765 -19.078 0.37 46.67  ? 1011 B1A A N2  1 
HETATM 4822 N  N2  B B1A L 7 .   ? -6.926  -71.862 -19.106 0.33 31.41  ? 1011 B1A A N2  1 
HETATM 4823 C  C9  A B1A L 7 .   ? -5.672  -71.275 -19.472 0.37 46.02  ? 1011 B1A A C9  1 
HETATM 4824 C  C9  B B1A L 7 .   ? -8.190  -71.556 -19.645 0.33 30.69  ? 1011 B1A A C9  1 
HETATM 4825 C  C11 A B1A L 7 .   ? -4.331  -69.560 -20.484 0.37 47.11  ? 1011 B1A A C11 1 
HETATM 4826 C  C11 B B1A L 7 .   ? -10.540 -71.176 -19.336 0.33 31.97  ? 1011 B1A A C11 1 
HETATM 4827 C  C12 A B1A L 7 .   ? -3.207  -70.337 -20.329 0.37 47.25  ? 1011 B1A A C12 1 
HETATM 4828 C  C12 B B1A L 7 .   ? -10.678 -70.887 -20.674 0.33 32.10  ? 1011 B1A A C12 1 
HETATM 4829 C  C14 A B1A L 7 .   ? -4.534  -72.053 -19.314 0.37 46.26  ? 1011 B1A A C14 1 
HETATM 4830 C  C14 B B1A L 7 .   ? -8.336  -71.272 -20.996 0.33 33.66  ? 1011 B1A A C14 1 
HETATM 4831 CL CL  . CL  M 8 .   ? 4.029   -49.120 -29.708 1.00 37.11  ? 1012 CL  A CL  1 
HETATM 4832 O  O   . HOH N 9 .   ? -3.915  -52.488 -3.052  0.50 53.37  ? 1101 HOH A O   1 
HETATM 4833 O  O   . HOH N 9 .   ? -7.868  -71.381 -27.710 0.50 54.15  ? 1102 HOH A O   1 
HETATM 4834 O  O   . HOH N 9 .   ? -29.434 -56.126 -36.301 1.00 51.92  ? 1103 HOH A O   1 
HETATM 4835 O  O   . HOH N 9 .   ? -12.842 -21.987 -41.412 1.00 50.85  ? 1104 HOH A O   1 
HETATM 4836 O  O   . HOH N 9 .   ? -33.662 -47.858 -4.406  1.00 35.40  ? 1105 HOH A O   1 
HETATM 4837 O  O   . HOH N 9 .   ? -32.069 -71.135 -8.919  1.00 46.27  ? 1106 HOH A O   1 
HETATM 4838 O  O   . HOH N 9 .   ? -7.300  -59.584 -30.998 1.00 65.38  ? 1107 HOH A O   1 
HETATM 4839 O  O   . HOH N 9 .   ? -19.958 -66.362 -37.766 1.00 59.01  ? 1108 HOH A O   1 
HETATM 4840 O  O   . HOH N 9 .   ? -32.526 -60.771 -18.949 1.00 38.64  ? 1109 HOH A O   1 
HETATM 4841 O  O   . HOH N 9 .   ? -32.638 -52.120 -27.360 1.00 40.02  ? 1110 HOH A O   1 
HETATM 4842 O  O   . HOH N 9 .   ? -39.831 -64.298 -19.585 1.00 62.01  ? 1111 HOH A O   1 
HETATM 4843 O  O   . HOH N 9 .   ? -42.358 -63.311 -5.091  1.00 44.36  ? 1112 HOH A O   1 
HETATM 4844 O  O   . HOH N 9 .   ? -19.467 -27.494 -40.160 1.00 31.86  ? 1113 HOH A O   1 
HETATM 4845 O  O   . HOH N 9 .   ? -5.301  -58.631 -29.920 1.00 35.29  ? 1114 HOH A O   1 
HETATM 4846 O  O   . HOH N 9 .   ? 5.912   -45.001 -35.795 1.00 43.50  ? 1115 HOH A O   1 
HETATM 4847 O  O   . HOH N 9 .   ? -34.550 -20.366 -23.918 1.00 52.14  ? 1116 HOH A O   1 
HETATM 4848 O  O   . HOH N 9 .   ? -7.043  -20.521 -27.047 1.00 39.71  ? 1117 HOH A O   1 
HETATM 4849 O  O   . HOH N 9 .   ? -19.470 -17.048 -9.943  0.50 52.67  ? 1118 HOH A O   1 
HETATM 4850 O  O   . HOH N 9 .   ? -29.965 -50.621 -26.973 1.00 41.74  ? 1119 HOH A O   1 
HETATM 4851 O  O   . HOH N 9 .   ? -17.910 -62.232 -44.793 1.00 60.12  ? 1120 HOH A O   1 
HETATM 4852 O  O   . HOH N 9 .   ? 0.122   -33.104 -27.871 1.00 28.57  ? 1121 HOH A O   1 
HETATM 4853 O  O   . HOH N 9 .   ? -22.073 -10.359 -9.474  1.00 56.64  ? 1122 HOH A O   1 
HETATM 4854 O  O   . HOH N 9 .   ? -7.755  -43.039 -42.856 1.00 43.58  ? 1123 HOH A O   1 
HETATM 4855 O  O   . HOH N 9 .   ? -5.004  -15.710 -28.232 1.00 49.17  ? 1124 HOH A O   1 
HETATM 4856 O  O   . HOH N 9 .   ? 2.670   -39.807 -26.911 1.00 30.46  ? 1125 HOH A O   1 
HETATM 4857 O  O   . HOH N 9 .   ? -23.237 -65.219 -38.875 1.00 46.47  ? 1126 HOH A O   1 
HETATM 4858 O  O   . HOH N 9 .   ? -0.790  -73.743 -21.746 1.00 47.35  ? 1127 HOH A O   1 
HETATM 4859 O  O   . HOH N 9 .   ? -28.070 -18.321 -34.886 1.00 54.71  ? 1128 HOH A O   1 
HETATM 4860 O  O   . HOH N 9 .   ? -9.040  -37.172 -19.708 1.00 57.37  ? 1129 HOH A O   1 
HETATM 4861 O  O   . HOH N 9 .   ? -15.347 -22.028 -19.266 0.50 30.86  ? 1130 HOH A O   1 
HETATM 4862 O  O   . HOH N 9 .   ? -22.579 -53.577 -46.566 1.00 53.95  ? 1131 HOH A O   1 
HETATM 4863 O  O   . HOH N 9 .   ? -42.813 -18.526 -14.017 1.00 68.91  ? 1132 HOH A O   1 
HETATM 4864 O  O   . HOH N 9 .   ? -4.392  -54.606 -11.959 1.00 49.40  ? 1133 HOH A O   1 
HETATM 4865 O  O   . HOH N 9 .   ? -4.034  -57.597 -9.865  1.00 29.49  ? 1134 HOH A O   1 
HETATM 4866 O  O   . HOH N 9 .   ? -13.367 -13.020 -27.208 1.00 48.78  ? 1135 HOH A O   1 
HETATM 4867 O  O   . HOH N 9 .   ? -8.831  -64.142 -30.878 1.00 43.33  ? 1136 HOH A O   1 
HETATM 4868 O  O   . HOH N 9 .   ? -3.329  -20.399 -23.485 1.00 41.78  ? 1137 HOH A O   1 
HETATM 4869 O  O   . HOH N 9 .   ? -13.625 -74.696 -14.792 0.64 36.31  ? 1138 HOH A O   1 
HETATM 4870 O  O   . HOH N 9 .   ? -40.574 -57.925 -6.341  1.00 45.63  ? 1139 HOH A O   1 
HETATM 4871 O  O   . HOH N 9 .   ? -31.116 -74.061 -17.756 1.00 57.28  ? 1140 HOH A O   1 
HETATM 4872 O  O   . HOH N 9 .   ? -22.551 -19.915 -15.978 1.00 48.78  ? 1141 HOH A O   1 
HETATM 4873 O  O   . HOH N 9 .   ? -3.738  -55.139 -36.126 1.00 65.40  ? 1142 HOH A O   1 
HETATM 4874 O  O   . HOH N 9 .   ? -42.447 -63.547 -18.609 1.00 62.05  ? 1143 HOH A O   1 
HETATM 4875 O  O   . HOH N 9 .   ? 11.408  -34.649 -33.094 1.00 38.74  ? 1144 HOH A O   1 
HETATM 4876 O  O   . HOH N 9 .   ? -15.250 -54.641 -39.633 1.00 41.17  ? 1145 HOH A O   1 
HETATM 4877 O  O   . HOH N 9 .   ? -35.126 -50.529 -12.855 1.00 38.47  ? 1146 HOH A O   1 
HETATM 4878 O  O   . HOH N 9 .   ? -2.927  -42.152 -20.933 0.50 40.69  ? 1147 HOH A O   1 
HETATM 4879 O  O   . HOH N 9 .   ? -25.178 -20.973 -8.126  1.00 61.42  ? 1148 HOH A O   1 
HETATM 4880 O  O   . HOH N 9 .   ? 1.219   -21.665 -45.449 1.00 54.71  ? 1149 HOH A O   1 
HETATM 4881 O  O   . HOH N 9 .   ? 1.467   -32.603 -38.739 1.00 26.35  ? 1150 HOH A O   1 
HETATM 4882 O  O   . HOH N 9 .   ? -10.343 -75.503 -8.859  1.00 53.04  ? 1151 HOH A O   1 
HETATM 4883 O  O   . HOH N 9 .   ? -4.340  -53.928 -28.060 1.00 26.15  ? 1152 HOH A O   1 
HETATM 4884 O  O   . HOH N 9 .   ? -24.169 -69.723 -27.800 1.00 41.21  ? 1153 HOH A O   1 
HETATM 4885 O  O   . HOH N 9 .   ? -26.588 -25.675 -33.425 1.00 31.34  ? 1154 HOH A O   1 
HETATM 4886 O  O   . HOH N 9 .   ? 5.422   -30.313 -21.553 1.00 35.28  ? 1155 HOH A O   1 
HETATM 4887 O  O   . HOH N 9 .   ? -38.402 -67.924 -8.397  1.00 37.85  ? 1156 HOH A O   1 
HETATM 4888 O  O   . HOH N 9 .   ? -28.707 -69.893 -14.113 1.00 42.95  ? 1157 HOH A O   1 
HETATM 4889 O  O   . HOH N 9 .   ? -16.775 -32.492 -18.324 1.00 44.42  ? 1158 HOH A O   1 
HETATM 4890 O  O   . HOH N 9 .   ? -32.801 -63.779 -15.087 1.00 26.85  ? 1159 HOH A O   1 
HETATM 4891 O  O   . HOH N 9 .   ? -29.310 -63.584 -34.538 1.00 51.11  ? 1160 HOH A O   1 
HETATM 4892 O  O   . HOH N 9 .   ? -11.743 -47.489 -43.346 1.00 55.44  ? 1161 HOH A O   1 
HETATM 4893 O  O   . HOH N 9 .   ? 6.012   -31.727 -19.208 1.00 40.86  ? 1162 HOH A O   1 
HETATM 4894 O  O   . HOH N 9 .   ? -17.547 -41.778 -37.172 1.00 44.56  ? 1163 HOH A O   1 
HETATM 4895 O  O   . HOH N 9 .   ? -8.836  -26.474 -44.446 1.00 39.18  ? 1164 HOH A O   1 
HETATM 4896 O  O   . HOH N 9 .   ? -14.798 -17.391 -36.176 1.00 44.11  ? 1165 HOH A O   1 
HETATM 4897 O  O   . HOH N 9 .   ? -0.149  -55.459 -33.196 1.00 59.45  ? 1166 HOH A O   1 
HETATM 4898 O  O   . HOH N 9 .   ? -27.147 -65.704 -40.006 1.00 49.52  ? 1167 HOH A O   1 
HETATM 4899 O  O   . HOH N 9 .   ? -36.866 -50.529 -5.380  1.00 34.97  ? 1168 HOH A O   1 
HETATM 4900 O  O   . HOH N 9 .   ? 8.755   -40.335 -31.794 1.00 50.35  ? 1169 HOH A O   1 
HETATM 4901 O  O   . HOH N 9 .   ? -21.393 -49.766 -35.030 1.00 45.48  ? 1170 HOH A O   1 
HETATM 4902 O  O   . HOH N 9 .   ? -14.726 -64.309 -0.479  1.00 24.66  ? 1171 HOH A O   1 
HETATM 4903 O  O   . HOH N 9 .   ? -8.409  -65.108 -7.001  1.00 28.29  ? 1172 HOH A O   1 
HETATM 4904 O  O   . HOH N 9 .   ? -27.243 -9.114  -30.207 1.00 57.52  ? 1173 HOH A O   1 
HETATM 4905 O  O   . HOH N 9 .   ? 4.129   -28.969 -44.149 1.00 40.17  ? 1174 HOH A O   1 
HETATM 4906 O  O   . HOH N 9 .   ? -18.004 -62.425 -2.971  1.00 22.68  ? 1175 HOH A O   1 
HETATM 4907 O  O   . HOH N 9 .   ? -26.521 -30.802 -23.466 1.00 49.61  ? 1176 HOH A O   1 
HETATM 4908 O  O   . HOH N 9 .   ? -42.634 -62.073 -14.817 1.00 36.12  ? 1177 HOH A O   1 
HETATM 4909 O  O   . HOH N 9 .   ? -13.009 -53.614 -40.776 1.00 52.42  ? 1178 HOH A O   1 
HETATM 4910 O  O   . HOH N 9 .   ? -31.841 -57.522 -21.640 1.00 31.04  ? 1179 HOH A O   1 
HETATM 4911 O  O   . HOH N 9 .   ? -22.599 -66.134 -23.755 1.00 34.75  ? 1180 HOH A O   1 
HETATM 4912 O  O   . HOH N 9 .   ? -40.312 -61.512 -11.410 1.00 26.37  ? 1181 HOH A O   1 
HETATM 4913 O  O   . HOH N 9 .   ? -17.364 -32.037 -42.192 0.50 38.07  ? 1182 HOH A O   1 
HETATM 4914 O  O   . HOH N 9 .   ? -28.473 -50.172 0.180   1.00 28.61  ? 1183 HOH A O   1 
HETATM 4915 O  O   . HOH N 9 .   ? -0.016  -31.458 -23.056 1.00 32.07  ? 1184 HOH A O   1 
HETATM 4916 O  O   . HOH N 9 .   ? 10.597  -27.188 -29.141 1.00 47.73  ? 1185 HOH A O   1 
HETATM 4917 O  O   . HOH N 9 .   ? -2.474  -55.750 -31.282 1.00 45.11  ? 1186 HOH A O   1 
HETATM 4918 O  O   . HOH N 9 .   ? -14.977 -35.036 -29.055 1.00 23.44  ? 1187 HOH A O   1 
HETATM 4919 O  O   . HOH N 9 .   ? -29.089 -17.738 -20.908 1.00 53.20  ? 1188 HOH A O   1 
HETATM 4920 O  O   . HOH N 9 .   ? 4.903   -16.712 -21.603 1.00 60.93  ? 1189 HOH A O   1 
HETATM 4921 O  O   . HOH N 9 .   ? -9.839  -64.519 -33.119 1.00 56.24  ? 1190 HOH A O   1 
HETATM 4922 O  O   . HOH N 9 .   ? 0.318   -65.026 -19.375 1.00 39.28  ? 1191 HOH A O   1 
HETATM 4923 O  O   . HOH N 9 .   ? 5.845   -32.985 -37.687 1.00 38.13  ? 1192 HOH A O   1 
HETATM 4924 O  O   . HOH N 9 .   ? -34.258 -21.947 -30.008 0.50 28.65  ? 1193 HOH A O   1 
HETATM 4925 O  O   . HOH N 9 .   ? 8.644   -24.151 -35.674 1.00 53.24  ? 1194 HOH A O   1 
HETATM 4926 O  O   . HOH N 9 .   ? 4.252   -26.858 -29.362 1.00 39.34  ? 1195 HOH A O   1 
HETATM 4927 O  O   . HOH N 9 .   ? -3.751  -15.618 -20.619 1.00 55.70  ? 1196 HOH A O   1 
HETATM 4928 O  O   . HOH N 9 .   ? -19.105 -20.711 -40.573 1.00 45.74  ? 1197 HOH A O   1 
HETATM 4929 O  O   . HOH N 9 .   ? -2.586  -58.236 -27.501 1.00 24.27  ? 1198 HOH A O   1 
HETATM 4930 O  O   . HOH N 9 .   ? -10.938 -62.619 -18.803 1.00 18.01  ? 1199 HOH A O   1 
HETATM 4931 O  O   . HOH N 9 .   ? -12.818 -42.860 -38.924 1.00 37.72  ? 1200 HOH A O   1 
HETATM 4932 O  O   . HOH N 9 .   ? -32.787 -14.465 -9.525  0.50 35.09  ? 1201 HOH A O   1 
HETATM 4933 O  O   . HOH N 9 .   ? -26.538 -71.547 -3.656  1.00 34.90  ? 1202 HOH A O   1 
HETATM 4934 O  O   . HOH N 9 .   ? -7.361  -47.539 -18.083 1.00 31.90  ? 1203 HOH A O   1 
HETATM 4935 O  O   . HOH N 9 .   ? 2.509   -44.432 -41.347 1.00 47.89  ? 1204 HOH A O   1 
HETATM 4936 O  O   . HOH N 9 .   ? -9.364  -21.576 -27.180 1.00 36.89  ? 1205 HOH A O   1 
HETATM 4937 O  O   . HOH N 9 .   ? -10.990 -48.484 -39.193 1.00 27.65  ? 1206 HOH A O   1 
HETATM 4938 O  O   . HOH N 9 .   ? -35.572 -66.875 -0.668  1.00 33.71  ? 1207 HOH A O   1 
HETATM 4939 O  O   . HOH N 9 .   ? -9.094  -59.335 -13.305 1.00 22.09  ? 1208 HOH A O   1 
HETATM 4940 O  O   . HOH N 9 .   ? -15.055 -20.215 -21.812 1.00 48.11  ? 1209 HOH A O   1 
HETATM 4941 O  O   . HOH N 9 .   ? -3.800  -61.818 -15.511 1.00 27.79  ? 1210 HOH A O   1 
HETATM 4942 O  O   . HOH N 9 .   ? -21.904 -66.355 -4.531  1.00 38.91  ? 1211 HOH A O   1 
HETATM 4943 O  O   . HOH N 9 .   ? -29.564 -33.819 -28.898 1.00 59.29  ? 1212 HOH A O   1 
HETATM 4944 O  O   . HOH N 9 .   ? -22.280 -74.529 -11.768 1.00 28.33  ? 1213 HOH A O   1 
HETATM 4945 O  O   . HOH N 9 .   ? -22.453 -51.296 -9.151  1.00 25.22  ? 1214 HOH A O   1 
HETATM 4946 O  O   . HOH N 9 .   ? -15.372 -66.126 -33.943 1.00 43.84  ? 1215 HOH A O   1 
HETATM 4947 O  O   . HOH N 9 .   ? -21.040 -47.368 -10.091 1.00 48.25  ? 1216 HOH A O   1 
HETATM 4948 O  O   . HOH N 9 .   ? -12.515 -76.059 -26.415 0.64 53.37  ? 1217 HOH A O   1 
HETATM 4949 O  O   . HOH N 9 .   ? -28.539 -68.146 -29.950 1.00 58.92  ? 1218 HOH A O   1 
HETATM 4950 O  O   . HOH N 9 .   ? -4.331  -65.669 -15.187 1.00 31.58  ? 1219 HOH A O   1 
HETATM 4951 O  O   . HOH N 9 .   ? -15.538 -21.617 -16.512 0.50 59.30  ? 1220 HOH A O   1 
HETATM 4952 O  O   . HOH N 9 .   ? -20.701 -29.288 -25.014 1.00 38.88  ? 1221 HOH A O   1 
HETATM 4953 O  O   . HOH N 9 .   ? -40.006 -24.333 -26.700 1.00 48.26  ? 1222 HOH A O   1 
HETATM 4954 O  O   . HOH N 9 .   ? -21.087 -65.510 -40.970 1.00 42.48  ? 1223 HOH A O   1 
HETATM 4955 O  O   . HOH N 9 .   ? -5.787  -59.430 -12.243 1.00 36.29  ? 1224 HOH A O   1 
HETATM 4956 O  O   . HOH N 9 .   ? 2.765   -64.755 -20.763 1.00 22.33  ? 1225 HOH A O   1 
HETATM 4957 O  O   . HOH N 9 .   ? -12.513 -58.432 -0.000  0.50 21.05  ? 1226 HOH A O   1 
HETATM 4958 O  O   . HOH N 9 .   ? -41.238 -58.432 -9.913  0.50 28.75  ? 1227 HOH A O   1 
HETATM 4959 O  O   . HOH N 9 .   ? -35.943 -57.576 -30.696 1.00 63.03  ? 1228 HOH A O   1 
HETATM 4960 O  O   . HOH N 9 .   ? -38.901 -57.378 -20.464 1.00 41.53  ? 1229 HOH A O   1 
HETATM 4961 O  O   . HOH N 9 .   ? 10.510  -30.079 -34.185 1.00 43.73  ? 1230 HOH A O   1 
HETATM 4962 O  O   . HOH N 9 .   ? -18.781 -65.452 -7.199  1.00 19.58  ? 1231 HOH A O   1 
HETATM 4963 O  O   . HOH N 9 .   ? -3.092  -55.379 -18.107 1.00 26.19  ? 1232 HOH A O   1 
HETATM 4964 O  O   . HOH N 9 .   ? 10.529  -38.740 -29.715 1.00 64.76  ? 1233 HOH A O   1 
HETATM 4965 O  O   . HOH N 9 .   ? -24.715 -14.529 -4.841  1.00 53.52  ? 1234 HOH A O   1 
HETATM 4966 O  O   . HOH N 9 .   ? 7.905   -43.154 -36.257 1.00 45.46  ? 1235 HOH A O   1 
HETATM 4967 O  O   . HOH N 9 .   ? -13.660 -45.536 -3.405  1.00 62.91  ? 1236 HOH A O   1 
HETATM 4968 O  O   . HOH N 9 .   ? -5.392  -60.548 -0.739  1.00 32.28  ? 1237 HOH A O   1 
HETATM 4969 O  O   . HOH N 9 .   ? -30.374 -57.161 -34.299 1.00 33.44  ? 1238 HOH A O   1 
HETATM 4970 O  O   . HOH N 9 .   ? 2.994   -51.545 -26.917 1.00 31.07  ? 1239 HOH A O   1 
HETATM 4971 O  O   . HOH N 9 .   ? -4.744  -62.703 -4.617  1.00 35.98  ? 1240 HOH A O   1 
HETATM 4972 O  O   . HOH N 9 .   ? -5.259  -48.905 -28.687 1.00 26.62  ? 1241 HOH A O   1 
HETATM 4973 O  O   . HOH N 9 .   ? -27.472 -52.649 -42.015 1.00 48.92  ? 1242 HOH A O   1 
HETATM 4974 O  O   . HOH N 9 .   ? -0.751  -11.335 -30.057 1.00 55.15  ? 1243 HOH A O   1 
HETATM 4975 O  O   . HOH N 9 .   ? -24.514 -69.831 -34.180 1.00 61.74  ? 1244 HOH A O   1 
HETATM 4976 O  O   . HOH N 9 .   ? -23.056 -27.683 -24.860 1.00 36.47  ? 1245 HOH A O   1 
HETATM 4977 O  O   . HOH N 9 .   ? -20.705 -19.727 -38.824 1.00 59.17  ? 1246 HOH A O   1 
HETATM 4978 O  O   . HOH N 9 .   ? -31.729 -60.311 -15.857 1.00 28.41  ? 1247 HOH A O   1 
HETATM 4979 O  O   . HOH N 9 .   ? -5.820  -68.656 -27.582 1.00 28.75  ? 1248 HOH A O   1 
HETATM 4980 O  O   . HOH N 9 .   ? -6.535  -37.124 -20.544 1.00 47.88  ? 1249 HOH A O   1 
HETATM 4981 O  O   . HOH N 9 .   ? -27.224 -57.258 -39.932 1.00 42.60  ? 1250 HOH A O   1 
HETATM 4982 O  O   . HOH N 9 .   ? 3.700   -37.739 -44.139 1.00 51.25  ? 1251 HOH A O   1 
HETATM 4983 O  O   . HOH N 9 .   ? -34.776 -63.038 0.700   1.00 23.63  ? 1252 HOH A O   1 
HETATM 4984 O  O   . HOH N 9 .   ? 5.808   -20.005 -43.207 1.00 56.23  ? 1253 HOH A O   1 
HETATM 4985 O  O   . HOH N 9 .   ? -38.482 -61.142 -14.263 1.00 31.48  ? 1254 HOH A O   1 
HETATM 4986 O  O   . HOH N 9 .   ? -22.931 -21.004 -37.916 1.00 49.08  ? 1255 HOH A O   1 
HETATM 4987 O  O   . HOH N 9 .   ? -12.253 -37.088 -39.655 1.00 29.00  ? 1256 HOH A O   1 
HETATM 4988 O  O   . HOH N 9 .   ? -19.164 -48.152 1.886   1.00 40.77  ? 1257 HOH A O   1 
HETATM 4989 O  O   . HOH N 9 .   ? -38.571 -38.235 -26.397 1.00 58.75  ? 1258 HOH A O   1 
HETATM 4990 O  O   . HOH N 9 .   ? -32.567 -49.080 -19.032 1.00 44.13  ? 1259 HOH A O   1 
HETATM 4991 O  O   . HOH N 9 .   ? -17.759 -66.187 -36.287 1.00 46.55  ? 1260 HOH A O   1 
HETATM 4992 O  O   . HOH N 9 .   ? -28.913 -46.086 2.623   1.00 43.77  ? 1261 HOH A O   1 
HETATM 4993 O  O   . HOH N 9 .   ? 1.100   -41.811 -24.316 1.00 35.99  ? 1262 HOH A O   1 
HETATM 4994 O  O   . HOH N 9 .   ? -14.094 -52.511 -5.882  1.00 23.88  ? 1263 HOH A O   1 
HETATM 4995 O  O   . HOH N 9 .   ? -13.665 -53.855 -1.504  1.00 23.58  ? 1264 HOH A O   1 
HETATM 4996 O  O   . HOH N 9 .   ? -19.074 -70.011 -8.217  1.00 27.96  ? 1265 HOH A O   1 
HETATM 4997 O  O   . HOH N 9 .   ? -38.769 -55.264 -19.008 1.00 37.40  ? 1266 HOH A O   1 
HETATM 4998 O  O   . HOH N 9 .   ? -1.780  -53.060 -35.756 1.00 61.73  ? 1267 HOH A O   1 
HETATM 4999 O  O   . HOH N 9 .   ? 7.093   -50.022 -30.683 1.00 57.57  ? 1268 HOH A O   1 
HETATM 5000 O  O   . HOH N 9 .   ? 5.396   -38.745 -24.282 1.00 43.89  ? 1269 HOH A O   1 
HETATM 5001 O  O   . HOH N 9 .   ? -23.012 -33.581 -36.943 1.00 35.38  ? 1270 HOH A O   1 
HETATM 5002 O  O   . HOH N 9 .   ? -27.894 -23.153 -26.539 1.00 29.99  ? 1271 HOH A O   1 
HETATM 5003 O  O   . HOH N 9 .   ? -20.653 -50.453 1.230   1.00 33.24  ? 1272 HOH A O   1 
HETATM 5004 O  O   . HOH N 9 .   ? -22.777 -27.882 -18.978 1.00 51.37  ? 1273 HOH A O   1 
HETATM 5005 O  O   . HOH N 9 .   ? -40.969 -26.355 -17.880 0.50 40.07  ? 1274 HOH A O   1 
HETATM 5006 O  O   . HOH N 9 .   ? 3.677   -43.133 -43.240 1.00 53.28  ? 1275 HOH A O   1 
HETATM 5007 O  O   . HOH N 9 .   ? -39.514 -55.607 -6.248  1.00 38.22  ? 1276 HOH A O   1 
HETATM 5008 O  O   . HOH N 9 .   ? -5.841  -50.589 -18.644 1.00 30.33  ? 1277 HOH A O   1 
HETATM 5009 O  O   . HOH N 9 .   ? -30.179 -60.941 -23.039 1.00 28.74  ? 1278 HOH A O   1 
HETATM 5010 O  O   . HOH N 9 .   ? 7.763   -22.326 -24.284 1.00 42.58  ? 1279 HOH A O   1 
HETATM 5011 O  O   . HOH N 9 .   ? -13.910 -49.802 -31.981 1.00 33.62  ? 1280 HOH A O   1 
HETATM 5012 O  O   . HOH N 9 .   ? -8.903  -71.345 -14.829 1.00 32.93  ? 1281 HOH A O   1 
HETATM 5013 O  O   . HOH N 9 .   ? -33.734 -57.631 -19.636 1.00 38.64  ? 1282 HOH A O   1 
HETATM 5014 O  O   . HOH N 9 .   ? -17.031 -52.182 -15.528 1.00 19.10  ? 1283 HOH A O   1 
HETATM 5015 O  O   . HOH N 9 .   ? -9.747  -55.025 -41.452 1.00 55.23  ? 1284 HOH A O   1 
HETATM 5016 O  O   . HOH N 9 .   ? -4.383  -34.486 -14.473 1.00 54.05  ? 1285 HOH A O   1 
HETATM 5017 O  O   . HOH N 9 .   ? -20.126 -46.503 -25.426 1.00 32.76  ? 1286 HOH A O   1 
HETATM 5018 O  O   . HOH N 9 .   ? 11.318  -40.367 -36.919 0.50 52.05  ? 1287 HOH A O   1 
HETATM 5019 O  O   . HOH N 9 .   ? -29.251 -50.872 -30.096 1.00 59.81  ? 1288 HOH A O   1 
HETATM 5020 O  O   . HOH N 9 .   ? -23.420 -47.655 -33.565 0.50 37.10  ? 1289 HOH A O   1 
HETATM 5021 O  O   . HOH N 9 .   ? -36.236 -58.434 -20.723 1.00 42.83  ? 1290 HOH A O   1 
HETATM 5022 O  O   . HOH N 9 .   ? -25.032 -53.679 -1.874  1.00 24.69  ? 1291 HOH A O   1 
HETATM 5023 O  O   . HOH N 9 .   ? -20.571 -67.547 -25.387 1.00 27.21  ? 1292 HOH A O   1 
HETATM 5024 O  O   . HOH N 9 .   ? -2.202  -39.885 -45.738 1.00 44.87  ? 1293 HOH A O   1 
HETATM 5025 O  O   . HOH N 9 .   ? -13.651 -51.440 -43.094 1.00 51.82  ? 1294 HOH A O   1 
HETATM 5026 O  O   . HOH N 9 .   ? -22.032 -44.390 -31.181 1.00 42.03  ? 1295 HOH A O   1 
HETATM 5027 O  O   . HOH N 9 .   ? -22.693 -37.569 -37.378 1.00 40.53  ? 1296 HOH A O   1 
HETATM 5028 O  O   . HOH N 9 .   ? -27.881 -47.536 0.024   1.00 39.82  ? 1297 HOH A O   1 
HETATM 5029 O  O   . HOH N 9 .   ? -20.806 -31.824 -29.521 1.00 31.14  ? 1298 HOH A O   1 
HETATM 5030 O  O   . HOH N 9 .   ? -1.387  -69.806 -17.358 0.70 41.19  ? 1299 HOH A O   1 
HETATM 5031 O  O   . HOH N 9 .   ? -18.160 -69.499 -24.605 1.00 32.93  ? 1300 HOH A O   1 
HETATM 5032 O  O   . HOH N 9 .   ? -7.153  -49.986 -6.796  1.00 51.31  ? 1301 HOH A O   1 
HETATM 5033 O  O   . HOH N 9 .   ? -5.942  -49.339 -21.227 1.00 26.63  ? 1302 HOH A O   1 
HETATM 5034 O  O   . HOH N 9 .   ? -5.755  -33.258 -17.566 1.00 43.17  ? 1303 HOH A O   1 
HETATM 5035 O  O   . HOH N 9 .   ? -10.514 -41.587 -38.048 1.00 42.61  ? 1304 HOH A O   1 
HETATM 5036 O  O   . HOH N 9 .   ? -16.863 -28.817 -40.799 1.00 50.49  ? 1305 HOH A O   1 
HETATM 5037 O  O   . HOH N 9 .   ? -33.865 -47.484 -15.770 1.00 54.34  ? 1306 HOH A O   1 
HETATM 5038 O  O   . HOH N 9 .   ? -35.227 -59.507 -0.433  1.00 46.18  ? 1307 HOH A O   1 
HETATM 5039 O  O   . HOH N 9 .   ? -11.138 -69.856 -26.519 0.70 38.53  ? 1308 HOH A O   1 
HETATM 5040 O  O   . HOH N 9 .   ? 0.951   -38.791 -21.243 1.00 52.64  ? 1309 HOH A O   1 
HETATM 5041 O  O   . HOH N 9 .   ? -12.436 -67.121 -29.709 1.00 34.85  ? 1310 HOH A O   1 
HETATM 5042 O  O   . HOH N 9 .   ? -4.136  -23.369 -25.269 1.00 42.58  ? 1311 HOH A O   1 
HETATM 5043 O  O   . HOH N 9 .   ? -35.896 -54.324 -3.266  1.00 27.12  ? 1312 HOH A O   1 
HETATM 5044 O  O   . HOH N 9 .   ? -14.224 -56.684 -1.512  1.00 19.09  ? 1313 HOH A O   1 
HETATM 5045 O  O   . HOH N 9 .   ? -13.280 -68.850 -6.163  1.00 36.00  ? 1314 HOH A O   1 
HETATM 5046 O  O   . HOH N 9 .   ? -15.031 -36.817 -40.290 0.50 32.02  ? 1315 HOH A O   1 
HETATM 5047 O  O   . HOH N 9 .   ? -15.648 -55.082 -43.818 1.00 52.21  ? 1316 HOH A O   1 
HETATM 5048 O  O   . HOH N 9 .   ? -15.088 -48.787 -18.722 1.00 30.75  ? 1317 HOH A O   1 
HETATM 5049 O  O   . HOH N 9 .   ? -21.137 -41.651 -35.786 1.00 50.43  ? 1318 HOH A O   1 
HETATM 5050 O  O   . HOH N 9 .   ? -0.493  -35.896 -28.088 1.00 31.44  ? 1319 HOH A O   1 
HETATM 5051 O  O   . HOH N 9 .   ? -34.100 -70.305 -18.379 1.00 40.51  ? 1320 HOH A O   1 
HETATM 5052 O  O   . HOH N 9 .   ? -10.230 -25.810 -12.503 0.50 37.21  ? 1321 HOH A O   1 
HETATM 5053 O  O   . HOH N 9 .   ? -5.137  -34.708 -20.633 1.00 46.39  ? 1322 HOH A O   1 
HETATM 5054 O  O   . HOH N 9 .   ? -28.749 -63.217 -25.426 1.00 35.26  ? 1323 HOH A O   1 
HETATM 5055 O  O   . HOH N 9 .   ? -17.341 -57.691 -43.654 1.00 37.05  ? 1324 HOH A O   1 
HETATM 5056 O  O   . HOH N 9 .   ? -3.830  -71.139 -8.978  1.00 39.92  ? 1325 HOH A O   1 
HETATM 5057 O  O   . HOH N 9 .   ? -27.345 -15.712 -19.918 1.00 51.77  ? 1326 HOH A O   1 
HETATM 5058 O  O   . HOH N 9 .   ? -31.068 -45.412 -15.556 1.00 52.33  ? 1327 HOH A O   1 
HETATM 5059 O  O   . HOH N 9 .   ? -28.431 -49.372 -31.697 1.00 46.45  ? 1328 HOH A O   1 
HETATM 5060 O  O   . HOH N 9 .   ? -31.111 -71.957 -13.514 1.00 55.28  ? 1329 HOH A O   1 
HETATM 5061 O  O   . HOH N 9 .   ? -39.940 -63.774 -2.424  0.34 19.99  ? 1330 HOH A O   1 
HETATM 5062 O  O   . HOH N 9 .   ? -4.472  -52.849 -38.564 1.00 54.00  ? 1331 HOH A O   1 
HETATM 5063 O  O   . HOH N 9 .   ? -24.192 -58.155 -46.624 1.00 50.98  ? 1332 HOH A O   1 
HETATM 5064 O  O   . HOH N 9 .   ? -24.537 -68.944 -38.336 1.00 56.11  ? 1333 HOH A O   1 
HETATM 5065 O  O   . HOH N 9 .   ? -20.191 -38.049 -36.714 1.00 30.25  ? 1334 HOH A O   1 
HETATM 5066 O  O   . HOH N 9 .   ? -31.821 -18.993 -31.045 1.00 51.27  ? 1335 HOH A O   1 
HETATM 5067 O  O   . HOH N 9 .   ? -34.938 -59.821 -29.662 1.00 50.56  ? 1336 HOH A O   1 
HETATM 5068 O  O   . HOH N 9 .   ? -39.365 -62.288 -4.259  0.34 61.75  ? 1337 HOH A O   1 
HETATM 5069 O  O   . HOH N 9 .   ? -4.820  -56.572 -31.618 1.00 27.95  ? 1338 HOH A O   1 
HETATM 5070 O  O   . HOH N 9 .   ? -35.629 -58.697 -27.442 1.00 51.67  ? 1339 HOH A O   1 
HETATM 5071 O  O   . HOH N 9 .   ? -18.735 -49.692 -35.282 1.00 39.00  ? 1340 HOH A O   1 
HETATM 5072 O  O   . HOH N 9 .   ? 4.819   -43.372 -22.601 0.70 47.21  ? 1341 HOH A O   1 
HETATM 5073 O  O   . HOH N 9 .   ? -26.936 -51.533 -1.729  1.00 35.01  ? 1342 HOH A O   1 
HETATM 5074 O  O   . HOH N 9 .   ? -14.823 -54.440 -4.137  1.00 23.28  ? 1343 HOH A O   1 
HETATM 5075 O  O   . HOH N 9 .   ? 3.589   -31.665 -37.155 1.00 29.70  ? 1344 HOH A O   1 
HETATM 5076 O  O   . HOH N 9 .   ? -28.014 -16.938 -32.503 1.00 43.10  ? 1345 HOH A O   1 
HETATM 5077 O  O   . HOH N 9 .   ? 13.399  -30.779 -19.638 1.00 48.43  ? 1346 HOH A O   1 
HETATM 5078 O  O   . HOH N 9 .   ? -27.191 -26.856 -35.879 1.00 35.36  ? 1347 HOH A O   1 
HETATM 5079 O  O   . HOH N 9 .   ? -35.090 -67.731 -5.454  1.00 42.67  ? 1348 HOH A O   1 
HETATM 5080 O  O   . HOH N 9 .   ? -35.343 -25.651 -28.658 0.50 37.86  ? 1349 HOH A O   1 
HETATM 5081 O  O   . HOH N 9 .   ? -37.513 -52.697 -12.997 1.00 29.38  ? 1350 HOH A O   1 
HETATM 5082 O  O   . HOH N 9 .   ? -8.360  -17.201 -39.336 1.00 50.28  ? 1351 HOH A O   1 
HETATM 5083 O  O   . HOH N 9 .   ? -5.922  -69.298 -7.346  1.00 35.61  ? 1352 HOH A O   1 
HETATM 5084 O  O   . HOH N 9 .   ? -25.823 -20.798 -39.277 1.00 78.06  ? 1353 HOH A O   1 
HETATM 5085 O  O   . HOH N 9 .   ? -20.971 -75.828 -5.429  1.00 48.42  ? 1354 HOH A O   1 
HETATM 5086 O  O   . HOH N 9 .   ? -12.046 -44.435 -16.452 1.00 43.52  ? 1355 HOH A O   1 
HETATM 5087 O  O   . HOH N 9 .   ? -29.962 -61.665 -33.093 1.00 50.75  ? 1356 HOH A O   1 
HETATM 5088 O  O   . HOH N 9 .   ? -23.049 -75.523 -9.143  1.00 40.09  ? 1357 HOH A O   1 
HETATM 5089 O  O   . HOH N 9 .   ? -11.688 -72.051 -15.575 1.00 26.74  ? 1358 HOH A O   1 
HETATM 5090 O  O   . HOH N 9 .   ? -3.745  -56.778 -6.991  1.00 28.30  ? 1359 HOH A O   1 
HETATM 5091 O  O   . HOH N 9 .   ? -14.675 -69.079 -19.787 1.00 40.44  ? 1360 HOH A O   1 
HETATM 5092 O  O   . HOH N 9 .   ? -7.736  -62.245 -33.782 1.00 50.50  ? 1361 HOH A O   1 
HETATM 5093 O  O   . HOH N 9 .   ? -18.910 -45.761 -9.438  1.00 54.02  ? 1362 HOH A O   1 
HETATM 5094 O  O   . HOH N 9 .   ? -7.667  -30.128 -46.084 1.00 42.35  ? 1363 HOH A O   1 
HETATM 5095 O  O   . HOH N 9 .   ? 14.865  -32.374 -31.969 0.50 45.10  ? 1364 HOH A O   1 
HETATM 5096 O  O   . HOH N 9 .   ? -24.647 -30.758 -40.162 1.00 58.95  ? 1365 HOH A O   1 
HETATM 5097 O  O   . HOH N 9 .   ? 8.559   -39.722 -39.551 0.50 38.51  ? 1366 HOH A O   1 
HETATM 5098 O  O   . HOH N 9 .   ? -6.157  -39.924 -45.427 1.00 63.05  ? 1367 HOH A O   1 
HETATM 5099 O  O   . HOH N 9 .   ? -20.294 -31.580 -26.689 1.00 32.80  ? 1368 HOH A O   1 
HETATM 5100 O  O   . HOH N 9 .   ? -0.156  -48.242 -36.379 1.00 35.77  ? 1369 HOH A O   1 
HETATM 5101 O  O   . HOH N 9 .   ? -4.097  -57.414 -13.504 1.00 39.84  ? 1370 HOH A O   1 
HETATM 5102 O  O   . HOH N 9 .   ? -23.421 -49.777 -42.070 1.00 41.07  ? 1371 HOH A O   1 
HETATM 5103 O  O   . HOH N 9 .   ? -37.602 -68.590 -12.475 1.00 42.19  ? 1372 HOH A O   1 
HETATM 5104 O  O   . HOH N 9 .   ? -14.618 -12.901 -39.677 1.00 63.44  ? 1373 HOH A O   1 
HETATM 5105 O  O   . HOH N 9 .   ? -8.668  -31.267 -15.491 0.50 36.37  ? 1374 HOH A O   1 
HETATM 5106 O  O   . HOH N 9 .   ? -7.474  -51.462 -10.456 1.00 54.74  ? 1375 HOH A O   1 
HETATM 5107 O  O   . HOH N 9 .   ? -14.836 -46.288 3.274   1.00 52.48  ? 1376 HOH A O   1 
HETATM 5108 O  O   . HOH N 9 .   ? -11.109 -46.690 3.947   1.00 42.60  ? 1377 HOH A O   1 
HETATM 5109 O  O   . HOH N 9 .   ? -16.265 -49.436 -16.216 1.00 23.17  ? 1378 HOH A O   1 
HETATM 5110 O  O   . HOH N 9 .   ? -6.200  -43.390 -21.181 1.00 44.83  ? 1379 HOH A O   1 
HETATM 5111 O  O   . HOH N 9 .   ? -17.482 -71.713 -22.774 1.00 36.99  ? 1380 HOH A O   1 
HETATM 5112 O  O   . HOH N 9 .   ? -37.241 -62.230 -20.228 0.50 44.01  ? 1381 HOH A O   1 
HETATM 5113 O  O   . HOH N 9 .   ? -20.250 -70.971 -5.837  1.00 38.71  ? 1382 HOH A O   1 
HETATM 5114 O  O   . HOH N 9 .   ? -14.934 -71.089 -18.762 1.00 44.79  ? 1383 HOH A O   1 
HETATM 5115 O  O   . HOH N 9 .   ? 0.489   -23.585 -17.138 0.50 40.04  ? 1384 HOH A O   1 
HETATM 5116 O  O   . HOH N 9 .   ? -23.414 -45.730 -9.166  1.00 48.00  ? 1385 HOH A O   1 
HETATM 5117 O  O   . HOH N 9 .   ? -7.120  -57.809 -1.046  1.00 40.94  ? 1386 HOH A O   1 
HETATM 5118 O  O   . HOH N 9 .   ? -38.720 -52.297 -20.442 0.50 43.99  ? 1387 HOH A O   1 
HETATM 5119 O  O   . HOH N 9 .   ? 0.363   -45.657 -37.080 1.00 40.82  ? 1388 HOH A O   1 
HETATM 5120 O  O   . HOH N 9 .   ? -1.020  -32.655 -25.361 1.00 30.76  ? 1389 HOH A O   1 
HETATM 5121 O  O   . HOH N 9 .   ? -19.235 -64.881 -3.058  1.00 33.86  ? 1390 HOH A O   1 
HETATM 5122 O  O   . HOH N 9 .   ? -14.776 -57.314 -41.937 1.00 32.80  ? 1391 HOH A O   1 
HETATM 5123 O  O   . HOH N 9 .   ? -3.055  -58.371 -24.649 1.00 21.58  ? 1392 HOH A O   1 
HETATM 5124 O  O   . HOH N 9 .   ? 0.092   -45.943 -42.635 1.00 52.48  ? 1393 HOH A O   1 
HETATM 5125 O  O   . HOH N 9 .   ? -9.222  -35.436 -44.671 0.50 40.22  ? 1394 HOH A O   1 
HETATM 5126 O  O   . HOH N 9 .   ? -22.019 -30.070 -14.072 0.50 48.23  ? 1395 HOH A O   1 
HETATM 5127 O  O   . HOH N 9 .   ? -2.870  -55.876 -28.861 1.00 26.38  ? 1396 HOH A O   1 
HETATM 5128 O  O   . HOH N 9 .   ? -20.075 -38.382 -26.037 1.00 61.95  ? 1397 HOH A O   1 
HETATM 5129 O  O   . HOH N 9 .   ? 4.784   -69.352 -21.698 1.00 35.85  ? 1398 HOH A O   1 
HETATM 5130 O  O   . HOH N 9 .   ? -28.874 -70.141 -22.617 1.00 57.78  ? 1399 HOH A O   1 
HETATM 5131 O  O   . HOH N 9 .   ? -13.263 -32.869 -20.510 1.00 38.77  ? 1400 HOH A O   1 
HETATM 5132 O  O   . HOH N 9 .   ? -12.631 -37.962 -22.404 1.00 48.76  ? 1401 HOH A O   1 
HETATM 5133 O  O   . HOH N 9 .   ? -25.450 -24.057 -41.756 0.50 37.14  ? 1402 HOH A O   1 
HETATM 5134 O  O   . HOH N 9 .   ? -15.799 -27.393 -45.942 1.00 53.55  ? 1403 HOH A O   1 
HETATM 5135 O  O   . HOH N 9 .   ? -35.735 -51.083 -23.166 1.00 57.12  ? 1404 HOH A O   1 
HETATM 5136 O  O   . HOH N 9 .   ? -26.737 -67.966 -27.928 1.00 27.62  ? 1405 HOH A O   1 
HETATM 5137 O  O   . HOH N 9 .   ? -13.125 -11.475 -32.865 1.00 61.75  ? 1406 HOH A O   1 
HETATM 5138 O  O   . HOH N 9 .   ? -23.015 -63.235 -23.530 1.00 44.44  ? 1407 HOH A O   1 
HETATM 5139 O  O   . HOH N 9 .   ? -5.814  -59.005 -36.917 1.00 55.71  ? 1408 HOH A O   1 
HETATM 5140 O  O   . HOH N 9 .   ? -10.854 -68.775 -38.453 0.50 38.43  ? 1409 HOH A O   1 
HETATM 5141 O  O   . HOH N 9 .   ? -9.144  -72.039 -26.218 0.70 30.52  ? 1410 HOH A O   1 
HETATM 5142 O  O   . HOH N 9 .   ? 3.838   -41.588 -24.002 0.50 26.62  ? 1411 HOH A O   1 
HETATM 5143 O  O   . HOH N 9 .   ? -22.010 -31.463 -39.739 1.00 41.05  ? 1412 HOH A O   1 
HETATM 5144 O  O   . HOH N 9 .   ? 4.454   -62.713 -20.202 1.00 24.19  ? 1413 HOH A O   1 
HETATM 5145 O  O   . HOH N 9 .   ? 0.000   -58.432 -16.663 0.50 50.10  ? 1414 HOH A O   1 
HETATM 5146 O  O   . HOH N 9 .   ? -8.399  -68.356 -28.607 1.00 47.42  ? 1415 HOH A O   1 
HETATM 5147 O  O   . HOH N 9 .   ? -23.134 -37.062 -32.987 1.00 46.66  ? 1416 HOH A O   1 
HETATM 5148 O  O   . HOH N 9 .   ? -19.674 -43.913 -38.036 1.00 53.63  ? 1417 HOH A O   1 
HETATM 5149 O  O   . HOH N 9 .   ? -17.775 -47.446 -15.382 1.00 42.22  ? 1418 HOH A O   1 
HETATM 5150 O  O   . HOH N 9 .   ? -11.166 -39.554 -39.994 0.50 58.46  ? 1419 HOH A O   1 
HETATM 5151 O  O   . HOH N 9 .   ? 4.898   -51.256 -34.245 0.50 39.98  ? 1420 HOH A O   1 
HETATM 5152 O  O   . HOH N 9 .   ? -10.489 -17.846 -40.627 1.00 49.18  ? 1421 HOH A O   1 
HETATM 5153 O  O   . HOH N 9 .   ? -10.443 -34.327 -44.022 0.66 37.76  ? 1422 HOH A O   1 
HETATM 5154 O  O   . HOH N 9 .   ? -38.365 -28.219 -27.277 1.00 57.87  ? 1423 HOH A O   1 
HETATM 5155 O  O   . HOH N 9 .   ? -34.087 -49.661 -10.340 1.00 44.66  ? 1424 HOH A O   1 
HETATM 5156 O  O   . HOH N 9 .   ? -7.634  -30.373 -13.238 0.50 49.96  ? 1425 HOH A O   1 
HETATM 5157 O  O   . HOH N 9 .   ? 11.155  -38.667 -19.531 0.50 45.49  ? 1426 HOH A O   1 
HETATM 5158 O  O   . HOH N 9 .   ? -27.245 -73.976 -4.641  1.00 41.94  ? 1427 HOH A O   1 
HETATM 5159 O  O   . HOH N 9 .   ? -35.745 -57.642 -3.932  1.00 58.05  ? 1428 HOH A O   1 
HETATM 5160 O  O   . HOH N 9 .   ? -2.849  -52.152 -15.771 1.00 58.62  ? 1429 HOH A O   1 
HETATM 5161 O  O   . HOH N 9 .   ? -1.793  -65.518 -15.632 1.00 54.74  ? 1430 HOH A O   1 
HETATM 5162 O  O   . HOH N 9 .   ? -34.568 -70.319 -9.288  1.00 53.32  ? 1431 HOH A O   1 
HETATM 5163 O  O   . HOH N 9 .   ? -4.261  -65.104 -30.422 0.34 29.10  ? 1432 HOH A O   1 
HETATM 5164 O  O   . HOH N 9 .   ? -37.906 -52.475 -4.072  1.00 40.53  ? 1433 HOH A O   1 
HETATM 5165 O  O   . HOH N 9 .   ? -34.622 -49.597 -20.793 1.00 61.84  ? 1434 HOH A O   1 
HETATM 5166 O  O   . HOH N 9 .   ? 0.837   -31.578 -47.132 1.00 48.75  ? 1435 HOH A O   1 
HETATM 5167 O  O   . HOH N 9 .   ? -21.300 -43.902 -42.033 1.00 62.85  ? 1436 HOH A O   1 
HETATM 5168 O  O   . HOH N 9 .   ? -9.083  -62.621 -41.977 1.00 66.15  ? 1437 HOH A O   1 
HETATM 5169 O  O   . HOH N 9 .   ? -25.213 -27.645 -20.290 1.00 61.97  ? 1438 HOH A O   1 
HETATM 5170 O  O   . HOH N 9 .   ? -8.214  -76.064 -10.611 1.00 61.92  ? 1439 HOH A O   1 
HETATM 5171 O  O   . HOH N 9 .   ? -15.513 -45.931 -19.472 1.00 49.42  ? 1440 HOH A O   1 
HETATM 5172 O  O   . HOH N 9 .   ? -15.725 -69.429 -6.000  1.00 26.66  ? 1441 HOH A O   1 
HETATM 5173 O  O   . HOH N 9 .   ? -30.805 -16.920 -32.190 1.00 52.38  ? 1442 HOH A O   1 
HETATM 5174 O  O   . HOH N 9 .   ? -42.418 -66.445 -9.805  1.00 63.43  ? 1443 HOH A O   1 
HETATM 5175 O  O   . HOH N 9 .   ? -35.567 -71.051 -13.733 1.00 72.28  ? 1444 HOH A O   1 
HETATM 5176 O  O   . HOH N 9 .   ? -17.802 -28.112 -44.709 1.00 51.96  ? 1445 HOH A O   1 
HETATM 5177 O  O   . HOH N 9 .   ? -25.533 -20.669 -4.826  1.00 52.05  ? 1446 HOH A O   1 
HETATM 5178 O  O   . HOH N 9 .   ? -25.002 -28.665 -22.702 1.00 53.07  ? 1447 HOH A O   1 
HETATM 5179 O  O   . HOH N 9 .   ? -5.497  -31.482 -48.048 1.00 54.50  ? 1448 HOH A O   1 
HETATM 5180 O  O   . HOH N 9 .   ? -1.314  -55.305 -0.775  1.00 41.46  ? 1449 HOH A O   1 
HETATM 5181 O  O   . HOH N 9 .   ? -10.610 -38.268 -43.470 0.50 47.93  ? 1450 HOH A O   1 
HETATM 5182 O  O   . HOH N 9 .   ? -15.569 -41.876 -38.548 1.00 36.99  ? 1451 HOH A O   1 
HETATM 5183 O  O   . HOH N 9 .   ? -19.063 -39.817 -38.527 1.00 43.72  ? 1452 HOH A O   1 
HETATM 5184 O  O   . HOH N 9 .   ? -16.719 -39.088 -39.770 1.00 55.75  ? 1453 HOH A O   1 
HETATM 5185 O  O   . HOH N 9 .   ? -1.205  -63.126 -15.433 1.00 53.30  ? 1454 HOH A O   1 
HETATM 5186 O  O   . HOH N 9 .   ? -30.904 -59.803 -34.482 1.00 51.76  ? 1455 HOH A O   1 
HETATM 5187 O  O   . HOH N 9 .   ? 0.306   -62.640 -17.794 1.00 31.07  ? 1456 HOH A O   1 
HETATM 5188 O  O   . HOH N 9 .   ? -25.520 -76.586 -8.964  1.00 62.80  ? 1457 HOH A O   1 
HETATM 5189 O  O   . HOH N 9 .   ? 9.997   -43.090 -28.226 0.72 48.77  ? 1458 HOH A O   1 
HETATM 5190 O  O   . HOH N 9 .   ? -24.103 -36.018 -35.223 1.00 47.34  ? 1459 HOH A O   1 
HETATM 5191 O  O   . HOH N 9 .   ? -23.605 -75.602 -13.854 1.00 51.65  ? 1460 HOH A O   1 
HETATM 5192 O  O   . HOH N 9 .   ? 0.000   -58.432 -28.505 0.50 29.73  ? 1461 HOH A O   1 
HETATM 5193 O  O   . HOH N 9 .   ? -41.436 -56.916 -13.688 1.00 30.48  ? 1462 HOH A O   1 
HETATM 5194 O  O   . HOH N 9 .   ? -35.759 -48.259 -14.153 1.00 49.46  ? 1463 HOH A O   1 
HETATM 5195 O  O   . HOH N 9 .   ? -6.072  -45.482 -17.800 0.50 36.75  ? 1464 HOH A O   1 
HETATM 5196 O  O   . HOH N 9 .   ? -10.117 -28.233 -11.786 1.00 56.03  ? 1465 HOH A O   1 
HETATM 5197 O  O   . HOH N 9 .   ? -3.423  -50.867 -18.071 1.00 48.06  ? 1466 HOH A O   1 
HETATM 5198 O  O   . HOH N 9 .   ? -1.756  -55.884 -6.005  1.00 46.44  ? 1467 HOH A O   1 
HETATM 5199 O  O   . HOH N 9 .   ? -4.669  -66.667 -6.304  1.00 58.24  ? 1468 HOH A O   1 
HETATM 5200 O  O   . HOH N 9 .   ? -18.210 -68.138 -6.454  1.00 23.54  ? 1469 HOH A O   1 
HETATM 5201 O  O   . HOH N 9 .   ? -3.009  -56.769 -33.762 1.00 47.87  ? 1470 HOH A O   1 
HETATM 5202 O  O   . HOH N 9 .   ? -2.832  -57.027 0.584   1.00 35.56  ? 1471 HOH A O   1 
HETATM 5203 O  O   . HOH N 9 .   ? -37.453 -64.030 0.199   0.34 26.84  ? 1472 HOH A O   1 
HETATM 5204 O  O   . HOH N 9 .   ? -13.357 -78.727 -29.586 0.50 51.49  ? 1473 HOH A O   1 
HETATM 5205 O  O   . HOH N 9 .   ? -5.656  -64.440 -6.605  1.00 34.86  ? 1474 HOH A O   1 
HETATM 5206 O  O   . HOH N 9 .   ? -11.967 -35.687 -43.701 0.50 44.53  ? 1475 HOH A O   1 
HETATM 5207 O  O   . HOH N 9 .   ? -5.497  -50.880 -40.948 1.00 56.02  ? 1476 HOH A O   1 
HETATM 5208 O  O   . HOH N 9 .   ? -19.969 -68.528 -4.364  1.00 28.31  ? 1477 HOH A O   1 
HETATM 5209 O  O   . HOH N 9 .   ? -25.461 -44.143 -32.863 0.50 44.81  ? 1478 HOH A O   1 
HETATM 5210 O  O   . HOH N 9 .   ? -28.201 -65.326 -42.571 1.00 48.60  ? 1479 HOH A O   1 
HETATM 5211 O  O   . HOH N 9 .   ? -10.181 -40.370 -42.038 0.50 41.40  ? 1480 HOH A O   1 
HETATM 5212 O  O   . HOH N 9 .   ? -4.240  -60.827 -10.405 1.00 50.32  ? 1481 HOH A O   1 
HETATM 5213 O  O   . HOH N 9 .   ? -3.027  -60.305 -6.689  1.00 53.85  ? 1482 HOH A O   1 
HETATM 5214 O  O   . HOH N 9 .   ? -1.739  -59.639 -3.184  1.00 47.42  ? 1483 HOH A O   1 
HETATM 5215 O  O   . HOH N 9 .   ? 16.489  -34.301 -26.869 1.00 55.17  ? 1484 HOH A O   1 
HETATM 5216 O  O   . HOH N 9 .   ? -1.087  -57.799 -32.361 0.50 53.53  ? 1485 HOH A O   1 
HETATM 5217 O  O   . HOH N 9 .   ? -6.706  -48.531 1.817   0.34 31.95  ? 1486 HOH A O   1 
HETATM 5218 O  O   . HOH N 9 .   ? -44.351 -68.162 -15.780 1.00 60.14  ? 1487 HOH A O   1 
HETATM 5219 O  O   . HOH N 9 .   ? -28.311 -55.954 -44.947 1.00 55.13  ? 1488 HOH A O   1 
HETATM 5220 O  O   . HOH N 9 .   ? -34.018 -68.036 -22.947 0.50 51.10  ? 1489 HOH A O   1 
HETATM 5221 O  O   . HOH N 9 .   ? 12.934  -25.587 -26.677 1.00 59.24  ? 1490 HOH A O   1 
HETATM 5222 O  O   . HOH N 9 .   ? -43.088 -60.645 -1.924  1.00 52.82  ? 1491 HOH A O   1 
HETATM 5223 O  O   . HOH N 9 .   ? -4.171  -62.769 -9.021  1.00 47.58  ? 1492 HOH A O   1 
# 
