data_7I29
# 
_entry.id   7I29 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   7I29         pdb_00007i29 10.2210/pdb7i29/pdb 
WWPDB D_1001408224 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-02 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.entry_id                        7I29 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.recvd_initial_deposition_date   2025-03-06 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.SG_entry                        ? 
_pdbx_database_status.pdb_format_compatible           Y 
_pdbx_database_status.methods_development_category    ? 
# 
_pdbx_contact_author.id                 1 
_pdbx_contact_author.email              fr193@cabm.rutgers.edu 
_pdbx_contact_author.name_first         'Francesc Xavier' 
_pdbx_contact_author.name_last          Ruiz 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-0457-0030 
_pdbx_contact_author.name_mi            ? 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Aschenbrenner, J.C.' 1  ? 
'Saini, M.'           2  ? 
'Chopra, A.'          3  ? 
'Marples, P.G.'       4  ? 
'Balcomb, B.H.'       5  ? 
'Lithgo, R.M.'        6  ? 
'Fearon, D.'          7  ? 
'von Delft, F.'       8  ? 
'Ruiz, F.X.'          9  ? 
'Arnold, E.'          10 ? 
# 
_citation.id                        primary 
_citation.title                     
'Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_volume            ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.year                      ? 
_citation.journal_id_ASTM           ? 
_citation.country                   ? 
_citation.journal_id_ISSN           ? 
_citation.journal_id_CSD            0353 
_citation.book_publisher            ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_DOI      ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.identifier_ORCID 
_citation_author.ordinal 
primary 'Aschenbrenner, J.C.' ? 1  
primary 'Saini, M.'           ? 2  
primary 'Chopra, A.'          ? 3  
primary 'Marples, P.G.'       ? 4  
primary 'Balcomb, B.H.'       ? 5  
primary 'Lithgo, R.M.'        ? 6  
primary 'Fearon, D.'          ? 7  
primary 'von Delft, F.'       ? 8  
primary 'Ruiz, F.X.'          ? 9  
primary 'Arnold, E.'          ? 10 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'NS5 RNA-dependent RNA polymerase'                73890.008 1   ? ? ? ? 
2 non-polymer syn 'ZINC ION'                                        65.409    2   ? ? ? ? 
3 non-polymer syn '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'            195.237   1   ? ? ? ? 
4 non-polymer syn 'DIMETHYL SULFOXIDE'                              78.133    2   ? ? ? ? 
5 non-polymer syn 'DI(HYDROXYETHYL)ETHER'                           106.120   2   ? ? ? ? 
6 non-polymer syn 'PHOSPHATE ION'                                   94.971    2   ? ? ? ? 
7 non-polymer syn 'N-[4-(2-amino-1,3-thiazol-4-yl)phenyl]acetamide' 233.290   1   ? ? ? ? 
8 non-polymer syn 'CHLORIDE ION'                                    35.453    1   ? ? ? ? 
9 water       nat water                                             18.015    352 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;GPGIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAM
TDTTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAR
EAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENS
LSGVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRP
TPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGD
DCVVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQG
AGWSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPW
MEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_entity_poly.pdbx_seq_one_letter_code_can   
;GPGIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAM
TDTTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAR
EAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENS
LSGVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRP
TPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGD
DCVVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQG
AGWSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPW
MEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'ZINC ION'                                        ZN  
3 '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'            MES 
4 'DIMETHYL SULFOXIDE'                              DMS 
5 'DI(HYDROXYETHYL)ETHER'                           PEG 
6 'PHOSPHATE ION'                                   PO4 
7 'N-[4-(2-amino-1,3-thiazol-4-yl)phenyl]acetamide' O0J 
8 'CHLORIDE ION'                                    CL  
9 water                                             HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   PRO n 
1 3   GLY n 
1 4   ILE n 
1 5   GLU n 
1 6   SER n 
1 7   GLU n 
1 8   THR n 
1 9   PRO n 
1 10  ASN n 
1 11  LEU n 
1 12  ASP n 
1 13  ILE n 
1 14  ILE n 
1 15  GLY n 
1 16  LYS n 
1 17  ARG n 
1 18  ILE n 
1 19  GLU n 
1 20  LYS n 
1 21  ILE n 
1 22  LYS n 
1 23  GLN n 
1 24  GLU n 
1 25  HIS n 
1 26  GLU n 
1 27  THR n 
1 28  SER n 
1 29  TRP n 
1 30  HIS n 
1 31  TYR n 
1 32  ASP n 
1 33  GLN n 
1 34  ASP n 
1 35  HIS n 
1 36  PRO n 
1 37  TYR n 
1 38  LYS n 
1 39  THR n 
1 40  TRP n 
1 41  ALA n 
1 42  TYR n 
1 43  HIS n 
1 44  GLY n 
1 45  SER n 
1 46  TYR n 
1 47  GLU n 
1 48  THR n 
1 49  LYS n 
1 50  GLN n 
1 51  THR n 
1 52  GLY n 
1 53  SER n 
1 54  ALA n 
1 55  SER n 
1 56  SER n 
1 57  MET n 
1 58  VAL n 
1 59  ASN n 
1 60  GLY n 
1 61  VAL n 
1 62  VAL n 
1 63  ARG n 
1 64  LEU n 
1 65  LEU n 
1 66  THR n 
1 67  LYS n 
1 68  PRO n 
1 69  TRP n 
1 70  ASP n 
1 71  ILE n 
1 72  ILE n 
1 73  PRO n 
1 74  MET n 
1 75  VAL n 
1 76  THR n 
1 77  GLN n 
1 78  MET n 
1 79  ALA n 
1 80  MET n 
1 81  THR n 
1 82  ASP n 
1 83  THR n 
1 84  THR n 
1 85  PRO n 
1 86  PHE n 
1 87  GLY n 
1 88  GLN n 
1 89  GLN n 
1 90  ARG n 
1 91  VAL n 
1 92  PHE n 
1 93  LYS n 
1 94  GLU n 
1 95  LYS n 
1 96  VAL n 
1 97  ASP n 
1 98  THR n 
1 99  ARG n 
1 100 THR n 
1 101 GLN n 
1 102 GLU n 
1 103 PRO n 
1 104 LYS n 
1 105 GLU n 
1 106 GLY n 
1 107 THR n 
1 108 LYS n 
1 109 LYS n 
1 110 LEU n 
1 111 MET n 
1 112 LYS n 
1 113 ILE n 
1 114 THR n 
1 115 ALA n 
1 116 GLU n 
1 117 TRP n 
1 118 LEU n 
1 119 TRP n 
1 120 LYS n 
1 121 GLU n 
1 122 LEU n 
1 123 GLY n 
1 124 LYS n 
1 125 LYS n 
1 126 LYS n 
1 127 THR n 
1 128 PRO n 
1 129 ARG n 
1 130 MET n 
1 131 CYS n 
1 132 THR n 
1 133 ARG n 
1 134 GLU n 
1 135 GLU n 
1 136 PHE n 
1 137 THR n 
1 138 ARG n 
1 139 LYS n 
1 140 VAL n 
1 141 ARG n 
1 142 SER n 
1 143 ASN n 
1 144 ALA n 
1 145 ALA n 
1 146 LEU n 
1 147 GLY n 
1 148 ALA n 
1 149 ILE n 
1 150 PHE n 
1 151 THR n 
1 152 ASP n 
1 153 GLU n 
1 154 ASN n 
1 155 LYS n 
1 156 TRP n 
1 157 LYS n 
1 158 SER n 
1 159 ALA n 
1 160 ARG n 
1 161 GLU n 
1 162 ALA n 
1 163 VAL n 
1 164 GLU n 
1 165 ASP n 
1 166 SER n 
1 167 GLY n 
1 168 PHE n 
1 169 TRP n 
1 170 GLU n 
1 171 LEU n 
1 172 VAL n 
1 173 ASP n 
1 174 LYS n 
1 175 GLU n 
1 176 ARG n 
1 177 ASN n 
1 178 LEU n 
1 179 HIS n 
1 180 LEU n 
1 181 GLU n 
1 182 GLY n 
1 183 LYS n 
1 184 CYS n 
1 185 GLU n 
1 186 THR n 
1 187 CYS n 
1 188 VAL n 
1 189 TYR n 
1 190 ASN n 
1 191 MET n 
1 192 MET n 
1 193 GLY n 
1 194 LYS n 
1 195 ARG n 
1 196 GLU n 
1 197 LYS n 
1 198 LYS n 
1 199 LEU n 
1 200 GLY n 
1 201 GLU n 
1 202 PHE n 
1 203 GLY n 
1 204 LYS n 
1 205 ALA n 
1 206 LYS n 
1 207 GLY n 
1 208 SER n 
1 209 ARG n 
1 210 ALA n 
1 211 ILE n 
1 212 TRP n 
1 213 TYR n 
1 214 MET n 
1 215 TRP n 
1 216 LEU n 
1 217 GLY n 
1 218 ALA n 
1 219 ARG n 
1 220 PHE n 
1 221 LEU n 
1 222 GLU n 
1 223 PHE n 
1 224 GLU n 
1 225 ALA n 
1 226 LEU n 
1 227 GLY n 
1 228 PHE n 
1 229 LEU n 
1 230 ASN n 
1 231 GLU n 
1 232 ASP n 
1 233 HIS n 
1 234 TRP n 
1 235 PHE n 
1 236 SER n 
1 237 ARG n 
1 238 GLU n 
1 239 ASN n 
1 240 SER n 
1 241 LEU n 
1 242 SER n 
1 243 GLY n 
1 244 VAL n 
1 245 GLU n 
1 246 GLY n 
1 247 GLU n 
1 248 GLY n 
1 249 LEU n 
1 250 HIS n 
1 251 LYS n 
1 252 LEU n 
1 253 GLY n 
1 254 TYR n 
1 255 ILE n 
1 256 LEU n 
1 257 ARG n 
1 258 ASP n 
1 259 VAL n 
1 260 SER n 
1 261 LYS n 
1 262 LYS n 
1 263 GLU n 
1 264 GLY n 
1 265 GLY n 
1 266 ALA n 
1 267 MET n 
1 268 TYR n 
1 269 ALA n 
1 270 ASP n 
1 271 ASP n 
1 272 THR n 
1 273 ALA n 
1 274 GLY n 
1 275 TRP n 
1 276 ASP n 
1 277 THR n 
1 278 ARG n 
1 279 ILE n 
1 280 THR n 
1 281 LEU n 
1 282 GLU n 
1 283 ASP n 
1 284 LEU n 
1 285 LYS n 
1 286 ASN n 
1 287 GLU n 
1 288 GLU n 
1 289 MET n 
1 290 VAL n 
1 291 THR n 
1 292 ASN n 
1 293 HIS n 
1 294 MET n 
1 295 GLU n 
1 296 GLY n 
1 297 GLU n 
1 298 HIS n 
1 299 LYS n 
1 300 LYS n 
1 301 LEU n 
1 302 ALA n 
1 303 GLU n 
1 304 ALA n 
1 305 ILE n 
1 306 PHE n 
1 307 LYS n 
1 308 LEU n 
1 309 THR n 
1 310 TYR n 
1 311 GLN n 
1 312 ASN n 
1 313 LYS n 
1 314 VAL n 
1 315 VAL n 
1 316 ARG n 
1 317 VAL n 
1 318 GLN n 
1 319 ARG n 
1 320 PRO n 
1 321 THR n 
1 322 PRO n 
1 323 ARG n 
1 324 GLY n 
1 325 THR n 
1 326 VAL n 
1 327 MET n 
1 328 ASP n 
1 329 ILE n 
1 330 ILE n 
1 331 SER n 
1 332 ARG n 
1 333 ARG n 
1 334 ASP n 
1 335 GLN n 
1 336 ARG n 
1 337 GLY n 
1 338 SER n 
1 339 GLY n 
1 340 GLN n 
1 341 VAL n 
1 342 VAL n 
1 343 THR n 
1 344 TYR n 
1 345 GLY n 
1 346 LEU n 
1 347 ASN n 
1 348 THR n 
1 349 PHE n 
1 350 THR n 
1 351 ASN n 
1 352 MET n 
1 353 GLU n 
1 354 ALA n 
1 355 GLN n 
1 356 LEU n 
1 357 ILE n 
1 358 ARG n 
1 359 GLN n 
1 360 MET n 
1 361 GLU n 
1 362 GLY n 
1 363 GLU n 
1 364 GLY n 
1 365 VAL n 
1 366 PHE n 
1 367 LYS n 
1 368 SER n 
1 369 ILE n 
1 370 GLN n 
1 371 HIS n 
1 372 LEU n 
1 373 THR n 
1 374 VAL n 
1 375 THR n 
1 376 GLU n 
1 377 GLU n 
1 378 ILE n 
1 379 ALA n 
1 380 VAL n 
1 381 LYS n 
1 382 ASN n 
1 383 TRP n 
1 384 LEU n 
1 385 VAL n 
1 386 ARG n 
1 387 VAL n 
1 388 GLY n 
1 389 ARG n 
1 390 GLU n 
1 391 ARG n 
1 392 LEU n 
1 393 SER n 
1 394 ARG n 
1 395 MET n 
1 396 ALA n 
1 397 ILE n 
1 398 SER n 
1 399 GLY n 
1 400 ASP n 
1 401 ASP n 
1 402 CYS n 
1 403 VAL n 
1 404 VAL n 
1 405 LYS n 
1 406 PRO n 
1 407 LEU n 
1 408 ASP n 
1 409 ASP n 
1 410 ARG n 
1 411 PHE n 
1 412 ALA n 
1 413 SER n 
1 414 ALA n 
1 415 LEU n 
1 416 THR n 
1 417 ALA n 
1 418 LEU n 
1 419 ASN n 
1 420 ASP n 
1 421 MET n 
1 422 GLY n 
1 423 LYS n 
1 424 VAL n 
1 425 ARG n 
1 426 LYS n 
1 427 ASP n 
1 428 ILE n 
1 429 GLN n 
1 430 GLN n 
1 431 TRP n 
1 432 GLU n 
1 433 PRO n 
1 434 SER n 
1 435 ARG n 
1 436 GLY n 
1 437 TRP n 
1 438 ASN n 
1 439 ASP n 
1 440 TRP n 
1 441 THR n 
1 442 GLN n 
1 443 VAL n 
1 444 PRO n 
1 445 PHE n 
1 446 CYS n 
1 447 SER n 
1 448 HIS n 
1 449 HIS n 
1 450 PHE n 
1 451 HIS n 
1 452 GLU n 
1 453 LEU n 
1 454 ILE n 
1 455 MET n 
1 456 LYS n 
1 457 ASP n 
1 458 GLY n 
1 459 ARG n 
1 460 VAL n 
1 461 LEU n 
1 462 VAL n 
1 463 VAL n 
1 464 PRO n 
1 465 CYS n 
1 466 ARG n 
1 467 ASN n 
1 468 GLN n 
1 469 ASP n 
1 470 GLU n 
1 471 LEU n 
1 472 ILE n 
1 473 GLY n 
1 474 ARG n 
1 475 ALA n 
1 476 ARG n 
1 477 ILE n 
1 478 SER n 
1 479 GLN n 
1 480 GLY n 
1 481 ALA n 
1 482 GLY n 
1 483 TRP n 
1 484 SER n 
1 485 LEU n 
1 486 ARG n 
1 487 GLU n 
1 488 THR n 
1 489 ALA n 
1 490 CYS n 
1 491 LEU n 
1 492 GLY n 
1 493 LYS n 
1 494 SER n 
1 495 TYR n 
1 496 ALA n 
1 497 GLN n 
1 498 MET n 
1 499 TRP n 
1 500 SER n 
1 501 LEU n 
1 502 MET n 
1 503 TYR n 
1 504 PHE n 
1 505 HIS n 
1 506 ARG n 
1 507 ARG n 
1 508 ASP n 
1 509 LEU n 
1 510 ARG n 
1 511 LEU n 
1 512 ALA n 
1 513 ALA n 
1 514 ASN n 
1 515 ALA n 
1 516 ILE n 
1 517 CYS n 
1 518 SER n 
1 519 ALA n 
1 520 VAL n 
1 521 PRO n 
1 522 SER n 
1 523 HIS n 
1 524 TRP n 
1 525 VAL n 
1 526 PRO n 
1 527 THR n 
1 528 SER n 
1 529 ARG n 
1 530 THR n 
1 531 THR n 
1 532 TRP n 
1 533 SER n 
1 534 ILE n 
1 535 HIS n 
1 536 ALA n 
1 537 THR n 
1 538 HIS n 
1 539 GLU n 
1 540 TRP n 
1 541 MET n 
1 542 THR n 
1 543 THR n 
1 544 GLU n 
1 545 ASP n 
1 546 MET n 
1 547 LEU n 
1 548 THR n 
1 549 VAL n 
1 550 TRP n 
1 551 ASN n 
1 552 ARG n 
1 553 VAL n 
1 554 TRP n 
1 555 ILE n 
1 556 GLN n 
1 557 GLU n 
1 558 ASN n 
1 559 PRO n 
1 560 TRP n 
1 561 MET n 
1 562 GLU n 
1 563 ASP n 
1 564 LYS n 
1 565 THR n 
1 566 PRO n 
1 567 VAL n 
1 568 GLU n 
1 569 SER n 
1 570 TRP n 
1 571 GLU n 
1 572 GLU n 
1 573 ILE n 
1 574 PRO n 
1 575 TYR n 
1 576 LEU n 
1 577 GLY n 
1 578 LYS n 
1 579 ARG n 
1 580 GLU n 
1 581 ASP n 
1 582 GLN n 
1 583 TRP n 
1 584 CYS n 
1 585 GLY n 
1 586 SER n 
1 587 LEU n 
1 588 ILE n 
1 589 GLY n 
1 590 LEU n 
1 591 THR n 
1 592 SER n 
1 593 ARG n 
1 594 ALA n 
1 595 THR n 
1 596 TRP n 
1 597 ALA n 
1 598 LYS n 
1 599 ASN n 
1 600 ILE n 
1 601 GLN n 
1 602 THR n 
1 603 ALA n 
1 604 ILE n 
1 605 ASN n 
1 606 GLN n 
1 607 VAL n 
1 608 ARG n 
1 609 SER n 
1 610 LEU n 
1 611 ILE n 
1 612 GLY n 
1 613 ASN n 
1 614 GLU n 
1 615 GLU n 
1 616 TYR n 
1 617 THR n 
1 618 ASP n 
1 619 TYR n 
1 620 MET n 
1 621 PRO n 
1 622 SER n 
1 623 MET n 
1 624 LYS n 
1 625 ARG n 
1 626 PHE n 
1 627 ARG n 
1 628 ARG n 
1 629 GLU n 
1 630 GLU n 
1 631 GLU n 
1 632 GLU n 
1 633 ALA n 
1 634 GLY n 
1 635 VAL n 
1 636 LEU n 
1 637 TRP n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   637 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'dengue virus type 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     11060 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                           ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE                                          ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE                                        ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                                   ? 'C4 H7 N O4'     133.103 
CL  non-polymer         . 'CHLORIDE ION'                                    ? 'Cl -1'          35.453  
CYS 'L-peptide linking' y CYSTEINE                                          ? 'C3 H7 N O2 S'   121.158 
DMS non-polymer         . 'DIMETHYL SULFOXIDE'                              ? 'C2 H6 O S'      78.133  
GLN 'L-peptide linking' y GLUTAMINE                                         ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                                   ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                                           ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE                                         ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                                             ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE                                        ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE                                           ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                                            ? 'C6 H15 N2 O2 1' 147.195 
MES non-polymer         . '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'            ? 'C6 H13 N O4 S'  195.237 
MET 'L-peptide linking' y METHIONINE                                        ? 'C5 H11 N O2 S'  149.211 
O0J non-polymer         . 'N-[4-(2-amino-1,3-thiazol-4-yl)phenyl]acetamide' ? 'C11 H11 N3 O S' 233.290 
PEG non-polymer         . 'DI(HYDROXYETHYL)ETHER'                           ? 'C4 H10 O3'      106.120 
PHE 'L-peptide linking' y PHENYLALANINE                                     ? 'C9 H11 N O2'    165.189 
PO4 non-polymer         . 'PHOSPHATE ION'                                   ? 'O4 P -3'        94.971  
PRO 'L-peptide linking' y PROLINE                                           ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                                            ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE                                         ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                                        ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE                                          ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE                                            ? 'C5 H11 N O2'    117.146 
ZN  non-polymer         . 'ZINC ION'                                        ? 'Zn 2'           65.409  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   264 ?   ?   ?   A . n 
A 1 2   PRO 2   265 ?   ?   ?   A . n 
A 1 3   GLY 3   266 ?   ?   ?   A . n 
A 1 4   ILE 4   267 ?   ?   ?   A . n 
A 1 5   GLU 5   268 ?   ?   ?   A . n 
A 1 6   SER 6   269 ?   ?   ?   A . n 
A 1 7   GLU 7   270 ?   ?   ?   A . n 
A 1 8   THR 8   271 ?   ?   ?   A . n 
A 1 9   PRO 9   272 ?   ?   ?   A . n 
A 1 10  ASN 10  273 273 ASN ASN A . n 
A 1 11  LEU 11  274 274 LEU LEU A . n 
A 1 12  ASP 12  275 275 ASP ASP A . n 
A 1 13  ILE 13  276 276 ILE ILE A . n 
A 1 14  ILE 14  277 277 ILE ILE A . n 
A 1 15  GLY 15  278 278 GLY GLY A . n 
A 1 16  LYS 16  279 279 LYS LYS A . n 
A 1 17  ARG 17  280 280 ARG ARG A . n 
A 1 18  ILE 18  281 281 ILE ILE A . n 
A 1 19  GLU 19  282 282 GLU GLU A . n 
A 1 20  LYS 20  283 283 LYS LYS A . n 
A 1 21  ILE 21  284 284 ILE ILE A . n 
A 1 22  LYS 22  285 285 LYS LYS A . n 
A 1 23  GLN 23  286 286 GLN GLN A . n 
A 1 24  GLU 24  287 287 GLU GLU A . n 
A 1 25  HIS 25  288 288 HIS HIS A . n 
A 1 26  GLU 26  289 289 GLU GLU A . n 
A 1 27  THR 27  290 290 THR THR A . n 
A 1 28  SER 28  291 291 SER SER A . n 
A 1 29  TRP 29  292 292 TRP TRP A . n 
A 1 30  HIS 30  293 293 HIS HIS A . n 
A 1 31  TYR 31  294 294 TYR TYR A . n 
A 1 32  ASP 32  295 295 ASP ASP A . n 
A 1 33  GLN 33  296 296 GLN GLN A . n 
A 1 34  ASP 34  297 297 ASP ASP A . n 
A 1 35  HIS 35  298 298 HIS HIS A . n 
A 1 36  PRO 36  299 299 PRO PRO A . n 
A 1 37  TYR 37  300 300 TYR TYR A . n 
A 1 38  LYS 38  301 301 LYS LYS A . n 
A 1 39  THR 39  302 302 THR THR A . n 
A 1 40  TRP 40  303 303 TRP TRP A . n 
A 1 41  ALA 41  304 304 ALA ALA A . n 
A 1 42  TYR 42  305 305 TYR TYR A . n 
A 1 43  HIS 43  306 306 HIS HIS A . n 
A 1 44  GLY 44  307 307 GLY GLY A . n 
A 1 45  SER 45  308 308 SER SER A . n 
A 1 46  TYR 46  309 309 TYR TYR A . n 
A 1 47  GLU 47  310 ?   ?   ?   A . n 
A 1 48  THR 48  311 ?   ?   ?   A . n 
A 1 49  LYS 49  312 ?   ?   ?   A . n 
A 1 50  GLN 50  313 ?   ?   ?   A . n 
A 1 51  THR 51  314 ?   ?   ?   A . n 
A 1 52  GLY 52  315 ?   ?   ?   A . n 
A 1 53  SER 53  316 ?   ?   ?   A . n 
A 1 54  ALA 54  317 ?   ?   ?   A . n 
A 1 55  SER 55  318 318 SER SER A . n 
A 1 56  SER 56  319 319 SER SER A . n 
A 1 57  MET 57  320 320 MET MET A . n 
A 1 58  VAL 58  321 321 VAL VAL A . n 
A 1 59  ASN 59  322 322 ASN ASN A . n 
A 1 60  GLY 60  323 323 GLY GLY A . n 
A 1 61  VAL 61  324 324 VAL VAL A . n 
A 1 62  VAL 62  325 325 VAL VAL A . n 
A 1 63  ARG 63  326 326 ARG ARG A . n 
A 1 64  LEU 64  327 327 LEU LEU A . n 
A 1 65  LEU 65  328 328 LEU LEU A . n 
A 1 66  THR 66  329 329 THR THR A . n 
A 1 67  LYS 67  330 330 LYS LYS A . n 
A 1 68  PRO 68  331 331 PRO PRO A . n 
A 1 69  TRP 69  332 332 TRP TRP A . n 
A 1 70  ASP 70  333 333 ASP ASP A . n 
A 1 71  ILE 71  334 334 ILE ILE A . n 
A 1 72  ILE 72  335 335 ILE ILE A . n 
A 1 73  PRO 73  336 336 PRO PRO A . n 
A 1 74  MET 74  337 337 MET MET A . n 
A 1 75  VAL 75  338 338 VAL VAL A . n 
A 1 76  THR 76  339 339 THR THR A . n 
A 1 77  GLN 77  340 340 GLN GLN A . n 
A 1 78  MET 78  341 341 MET MET A . n 
A 1 79  ALA 79  342 342 ALA ALA A . n 
A 1 80  MET 80  343 343 MET MET A . n 
A 1 81  THR 81  344 344 THR GLY A . n 
A 1 82  ASP 82  345 ?   ?   ?   A . n 
A 1 83  THR 83  346 ?   ?   ?   A . n 
A 1 84  THR 84  347 ?   ?   ?   A . n 
A 1 85  PRO 85  348 ?   ?   ?   A . n 
A 1 86  PHE 86  349 ?   ?   ?   A . n 
A 1 87  GLY 87  350 ?   ?   ?   A . n 
A 1 88  GLN 88  351 ?   ?   ?   A . n 
A 1 89  GLN 89  352 ?   ?   ?   A . n 
A 1 90  ARG 90  353 ?   ?   ?   A . n 
A 1 91  VAL 91  354 ?   ?   ?   A . n 
A 1 92  PHE 92  355 ?   ?   ?   A . n 
A 1 93  LYS 93  356 ?   ?   ?   A . n 
A 1 94  GLU 94  357 ?   ?   ?   A . n 
A 1 95  LYS 95  358 358 LYS LYS A . n 
A 1 96  VAL 96  359 359 VAL VAL A . n 
A 1 97  ASP 97  360 360 ASP ASP A . n 
A 1 98  THR 98  361 361 THR THR A . n 
A 1 99  ARG 99  362 362 ARG ARG A . n 
A 1 100 THR 100 363 363 THR THR A . n 
A 1 101 GLN 101 364 364 GLN GLN A . n 
A 1 102 GLU 102 365 365 GLU GLU A . n 
A 1 103 PRO 103 366 366 PRO PRO A . n 
A 1 104 LYS 104 367 367 LYS LYS A . n 
A 1 105 GLU 105 368 368 GLU GLU A . n 
A 1 106 GLY 106 369 369 GLY GLY A . n 
A 1 107 THR 107 370 370 THR THR A . n 
A 1 108 LYS 108 371 371 LYS LYS A . n 
A 1 109 LYS 109 372 372 LYS LYS A . n 
A 1 110 LEU 110 373 373 LEU LEU A . n 
A 1 111 MET 111 374 374 MET MET A . n 
A 1 112 LYS 112 375 375 LYS LYS A . n 
A 1 113 ILE 113 376 376 ILE ILE A . n 
A 1 114 THR 114 377 377 THR THR A . n 
A 1 115 ALA 115 378 378 ALA ALA A . n 
A 1 116 GLU 116 379 379 GLU GLU A . n 
A 1 117 TRP 117 380 380 TRP TRP A . n 
A 1 118 LEU 118 381 381 LEU LEU A . n 
A 1 119 TRP 119 382 382 TRP TRP A . n 
A 1 120 LYS 120 383 383 LYS LYS A . n 
A 1 121 GLU 121 384 384 GLU GLU A . n 
A 1 122 LEU 122 385 385 LEU LEU A . n 
A 1 123 GLY 123 386 386 GLY GLY A . n 
A 1 124 LYS 124 387 387 LYS LYS A . n 
A 1 125 LYS 125 388 388 LYS LYS A . n 
A 1 126 LYS 126 389 389 LYS LYS A . n 
A 1 127 THR 127 390 390 THR THR A . n 
A 1 128 PRO 128 391 391 PRO PRO A . n 
A 1 129 ARG 129 392 392 ARG ARG A . n 
A 1 130 MET 130 393 393 MET MET A . n 
A 1 131 CYS 131 394 394 CYS CYS A . n 
A 1 132 THR 132 395 395 THR THR A . n 
A 1 133 ARG 133 396 396 ARG ARG A . n 
A 1 134 GLU 134 397 397 GLU GLU A . n 
A 1 135 GLU 135 398 398 GLU GLU A . n 
A 1 136 PHE 136 399 399 PHE PHE A . n 
A 1 137 THR 137 400 400 THR THR A . n 
A 1 138 ARG 138 401 401 ARG ARG A . n 
A 1 139 LYS 139 402 402 LYS LYS A . n 
A 1 140 VAL 140 403 403 VAL VAL A . n 
A 1 141 ARG 141 404 404 ARG ARG A . n 
A 1 142 SER 142 405 405 SER SER A . n 
A 1 143 ASN 143 406 406 ASN ASN A . n 
A 1 144 ALA 144 407 407 ALA ALA A . n 
A 1 145 ALA 145 408 408 ALA ALA A . n 
A 1 146 LEU 146 409 409 LEU LEU A . n 
A 1 147 GLY 147 410 410 GLY GLY A . n 
A 1 148 ALA 148 411 411 ALA ALA A . n 
A 1 149 ILE 149 412 412 ILE ILE A . n 
A 1 150 PHE 150 413 ?   ?   ?   A . n 
A 1 151 THR 151 414 ?   ?   ?   A . n 
A 1 152 ASP 152 415 ?   ?   ?   A . n 
A 1 153 GLU 153 416 ?   ?   ?   A . n 
A 1 154 ASN 154 417 ?   ?   ?   A . n 
A 1 155 LYS 155 418 ?   ?   ?   A . n 
A 1 156 TRP 156 419 419 TRP TRP A . n 
A 1 157 LYS 157 420 420 LYS LYS A . n 
A 1 158 SER 158 421 421 SER SER A . n 
A 1 159 ALA 159 422 422 ALA ALA A . n 
A 1 160 ARG 160 423 423 ARG ARG A . n 
A 1 161 GLU 161 424 424 GLU GLU A . n 
A 1 162 ALA 162 425 425 ALA ALA A . n 
A 1 163 VAL 163 426 426 VAL VAL A . n 
A 1 164 GLU 164 427 427 GLU GLU A . n 
A 1 165 ASP 165 428 428 ASP ASP A . n 
A 1 166 SER 166 429 429 SER SER A . n 
A 1 167 GLY 167 430 430 GLY GLY A . n 
A 1 168 PHE 168 431 431 PHE PHE A . n 
A 1 169 TRP 169 432 432 TRP TRP A . n 
A 1 170 GLU 170 433 433 GLU GLU A . n 
A 1 171 LEU 171 434 434 LEU LEU A . n 
A 1 172 VAL 172 435 435 VAL VAL A . n 
A 1 173 ASP 173 436 436 ASP ASP A . n 
A 1 174 LYS 174 437 437 LYS LYS A . n 
A 1 175 GLU 175 438 438 GLU GLU A . n 
A 1 176 ARG 176 439 439 ARG ARG A . n 
A 1 177 ASN 177 440 440 ASN ASN A . n 
A 1 178 LEU 178 441 441 LEU LEU A . n 
A 1 179 HIS 179 442 442 HIS HIS A . n 
A 1 180 LEU 180 443 443 LEU LEU A . n 
A 1 181 GLU 181 444 444 GLU GLU A . n 
A 1 182 GLY 182 445 445 GLY GLY A . n 
A 1 183 LYS 183 446 446 LYS LYS A . n 
A 1 184 CYS 184 447 447 CYS CYS A . n 
A 1 185 GLU 185 448 448 GLU GLU A . n 
A 1 186 THR 186 449 449 THR THR A . n 
A 1 187 CYS 187 450 450 CYS CYS A . n 
A 1 188 VAL 188 451 451 VAL VAL A . n 
A 1 189 TYR 189 452 452 TYR TYR A . n 
A 1 190 ASN 190 453 453 ASN ASN A . n 
A 1 191 MET 191 454 454 MET MET A . n 
A 1 192 MET 192 455 455 MET MET A . n 
A 1 193 GLY 193 456 ?   ?   ?   A . n 
A 1 194 LYS 194 457 ?   ?   ?   A . n 
A 1 195 ARG 195 458 ?   ?   ?   A . n 
A 1 196 GLU 196 459 ?   ?   ?   A . n 
A 1 197 LYS 197 460 ?   ?   ?   A . n 
A 1 198 LYS 198 461 ?   ?   ?   A . n 
A 1 199 LEU 199 462 ?   ?   ?   A . n 
A 1 200 GLY 200 463 ?   ?   ?   A . n 
A 1 201 GLU 201 464 ?   ?   ?   A . n 
A 1 202 PHE 202 465 ?   ?   ?   A . n 
A 1 203 GLY 203 466 ?   ?   ?   A . n 
A 1 204 LYS 204 467 ?   ?   ?   A . n 
A 1 205 ALA 205 468 ?   ?   ?   A . n 
A 1 206 LYS 206 469 ?   ?   ?   A . n 
A 1 207 GLY 207 470 ?   ?   ?   A . n 
A 1 208 SER 208 471 ?   ?   ?   A . n 
A 1 209 ARG 209 472 ?   ?   ?   A . n 
A 1 210 ALA 210 473 473 ALA ALA A . n 
A 1 211 ILE 211 474 474 ILE ILE A . n 
A 1 212 TRP 212 475 475 TRP TRP A . n 
A 1 213 TYR 213 476 476 TYR TYR A . n 
A 1 214 MET 214 477 477 MET MET A . n 
A 1 215 TRP 215 478 478 TRP TRP A . n 
A 1 216 LEU 216 479 479 LEU LEU A . n 
A 1 217 GLY 217 480 480 GLY GLY A . n 
A 1 218 ALA 218 481 481 ALA ALA A . n 
A 1 219 ARG 219 482 482 ARG ARG A . n 
A 1 220 PHE 220 483 483 PHE PHE A . n 
A 1 221 LEU 221 484 484 LEU LEU A . n 
A 1 222 GLU 222 485 485 GLU GLU A . n 
A 1 223 PHE 223 486 486 PHE PHE A . n 
A 1 224 GLU 224 487 487 GLU GLU A . n 
A 1 225 ALA 225 488 488 ALA ALA A . n 
A 1 226 LEU 226 489 489 LEU LEU A . n 
A 1 227 GLY 227 490 490 GLY GLY A . n 
A 1 228 PHE 228 491 491 PHE PHE A . n 
A 1 229 LEU 229 492 492 LEU LEU A . n 
A 1 230 ASN 230 493 493 ASN ASN A . n 
A 1 231 GLU 231 494 494 GLU GLU A . n 
A 1 232 ASP 232 495 495 ASP ASP A . n 
A 1 233 HIS 233 496 496 HIS HIS A . n 
A 1 234 TRP 234 497 497 TRP TRP A . n 
A 1 235 PHE 235 498 498 PHE PHE A . n 
A 1 236 SER 236 499 499 SER SER A . n 
A 1 237 ARG 237 500 500 ARG ARG A . n 
A 1 238 GLU 238 501 501 GLU GLU A . n 
A 1 239 ASN 239 502 502 ASN ASN A . n 
A 1 240 SER 240 503 503 SER SER A . n 
A 1 241 LEU 241 504 504 LEU LEU A . n 
A 1 242 SER 242 505 505 SER SER A . n 
A 1 243 GLY 243 506 506 GLY GLY A . n 
A 1 244 VAL 244 507 507 VAL VAL A . n 
A 1 245 GLU 245 508 508 GLU GLU A . n 
A 1 246 GLY 246 509 509 GLY GLY A . n 
A 1 247 GLU 247 510 510 GLU GLU A . n 
A 1 248 GLY 248 511 511 GLY GLY A . n 
A 1 249 LEU 249 512 512 LEU LEU A . n 
A 1 250 HIS 250 513 513 HIS HIS A . n 
A 1 251 LYS 251 514 514 LYS LYS A . n 
A 1 252 LEU 252 515 515 LEU LEU A . n 
A 1 253 GLY 253 516 516 GLY GLY A . n 
A 1 254 TYR 254 517 517 TYR TYR A . n 
A 1 255 ILE 255 518 518 ILE ILE A . n 
A 1 256 LEU 256 519 519 LEU LEU A . n 
A 1 257 ARG 257 520 520 ARG ARG A . n 
A 1 258 ASP 258 521 521 ASP ASP A . n 
A 1 259 VAL 259 522 522 VAL VAL A . n 
A 1 260 SER 260 523 523 SER SER A . n 
A 1 261 LYS 261 524 524 LYS LYS A . n 
A 1 262 LYS 262 525 525 LYS LYS A . n 
A 1 263 GLU 263 526 526 GLU GLU A . n 
A 1 264 GLY 264 527 527 GLY GLY A . n 
A 1 265 GLY 265 528 528 GLY GLY A . n 
A 1 266 ALA 266 529 529 ALA ALA A . n 
A 1 267 MET 267 530 530 MET MET A . n 
A 1 268 TYR 268 531 531 TYR TYR A . n 
A 1 269 ALA 269 532 532 ALA ALA A . n 
A 1 270 ASP 270 533 533 ASP ASP A . n 
A 1 271 ASP 271 534 534 ASP ASP A . n 
A 1 272 THR 272 535 535 THR THR A . n 
A 1 273 ALA 273 536 536 ALA ALA A . n 
A 1 274 GLY 274 537 537 GLY GLY A . n 
A 1 275 TRP 275 538 538 TRP TRP A . n 
A 1 276 ASP 276 539 539 ASP ASP A . n 
A 1 277 THR 277 540 540 THR THR A . n 
A 1 278 ARG 278 541 541 ARG ARG A . n 
A 1 279 ILE 279 542 542 ILE ILE A . n 
A 1 280 THR 280 543 543 THR THR A . n 
A 1 281 LEU 281 544 544 LEU LEU A . n 
A 1 282 GLU 282 545 545 GLU GLU A . n 
A 1 283 ASP 283 546 546 ASP ASP A . n 
A 1 284 LEU 284 547 547 LEU LEU A . n 
A 1 285 LYS 285 548 548 LYS LYS A . n 
A 1 286 ASN 286 549 549 ASN ASN A . n 
A 1 287 GLU 287 550 550 GLU GLU A . n 
A 1 288 GLU 288 551 551 GLU GLU A . n 
A 1 289 MET 289 552 552 MET MET A . n 
A 1 290 VAL 290 553 553 VAL VAL A . n 
A 1 291 THR 291 554 554 THR THR A . n 
A 1 292 ASN 292 555 555 ASN ASN A . n 
A 1 293 HIS 293 556 556 HIS HIS A . n 
A 1 294 MET 294 557 557 MET MET A . n 
A 1 295 GLU 295 558 558 GLU GLU A . n 
A 1 296 GLY 296 559 559 GLY GLY A . n 
A 1 297 GLU 297 560 560 GLU GLU A . n 
A 1 298 HIS 298 561 561 HIS HIS A . n 
A 1 299 LYS 299 562 562 LYS LYS A . n 
A 1 300 LYS 300 563 563 LYS LYS A . n 
A 1 301 LEU 301 564 564 LEU LEU A . n 
A 1 302 ALA 302 565 565 ALA ALA A . n 
A 1 303 GLU 303 566 566 GLU GLU A . n 
A 1 304 ALA 304 567 567 ALA ALA A . n 
A 1 305 ILE 305 568 568 ILE ILE A . n 
A 1 306 PHE 306 569 569 PHE PHE A . n 
A 1 307 LYS 307 570 570 LYS LYS A . n 
A 1 308 LEU 308 571 571 LEU LEU A . n 
A 1 309 THR 309 572 572 THR THR A . n 
A 1 310 TYR 310 573 573 TYR TYR A . n 
A 1 311 GLN 311 574 574 GLN GLN A . n 
A 1 312 ASN 312 575 575 ASN ASN A . n 
A 1 313 LYS 313 576 576 LYS LYS A . n 
A 1 314 VAL 314 577 577 VAL VAL A . n 
A 1 315 VAL 315 578 578 VAL VAL A . n 
A 1 316 ARG 316 579 579 ARG ARG A . n 
A 1 317 VAL 317 580 580 VAL VAL A . n 
A 1 318 GLN 318 581 581 GLN GLN A . n 
A 1 319 ARG 319 582 ?   ?   ?   A . n 
A 1 320 PRO 320 583 ?   ?   ?   A . n 
A 1 321 THR 321 584 ?   ?   ?   A . n 
A 1 322 PRO 322 585 ?   ?   ?   A . n 
A 1 323 ARG 323 586 ?   ?   ?   A . n 
A 1 324 GLY 324 587 ?   ?   ?   A . n 
A 1 325 THR 325 588 ?   ?   ?   A . n 
A 1 326 VAL 326 589 ?   ?   ?   A . n 
A 1 327 MET 327 590 590 MET MET A . n 
A 1 328 ASP 328 591 591 ASP ASP A . n 
A 1 329 ILE 329 592 592 ILE ILE A . n 
A 1 330 ILE 330 593 593 ILE ILE A . n 
A 1 331 SER 331 594 594 SER SER A . n 
A 1 332 ARG 332 595 595 ARG ARG A . n 
A 1 333 ARG 333 596 596 ARG ARG A . n 
A 1 334 ASP 334 597 597 ASP ASP A . n 
A 1 335 GLN 335 598 598 GLN GLN A . n 
A 1 336 ARG 336 599 599 ARG ARG A . n 
A 1 337 GLY 337 600 600 GLY GLY A . n 
A 1 338 SER 338 601 601 SER SER A . n 
A 1 339 GLY 339 602 602 GLY GLY A . n 
A 1 340 GLN 340 603 603 GLN GLN A . n 
A 1 341 VAL 341 604 604 VAL VAL A . n 
A 1 342 VAL 342 605 605 VAL VAL A . n 
A 1 343 THR 343 606 606 THR THR A . n 
A 1 344 TYR 344 607 607 TYR TYR A . n 
A 1 345 GLY 345 608 608 GLY GLY A . n 
A 1 346 LEU 346 609 609 LEU LEU A . n 
A 1 347 ASN 347 610 610 ASN ASN A . n 
A 1 348 THR 348 611 611 THR THR A . n 
A 1 349 PHE 349 612 612 PHE PHE A . n 
A 1 350 THR 350 613 613 THR THR A . n 
A 1 351 ASN 351 614 614 ASN ASN A . n 
A 1 352 MET 352 615 615 MET MET A . n 
A 1 353 GLU 353 616 616 GLU GLU A . n 
A 1 354 ALA 354 617 617 ALA ALA A . n 
A 1 355 GLN 355 618 618 GLN GLN A . n 
A 1 356 LEU 356 619 619 LEU LEU A . n 
A 1 357 ILE 357 620 620 ILE ILE A . n 
A 1 358 ARG 358 621 621 ARG ARG A . n 
A 1 359 GLN 359 622 622 GLN GLN A . n 
A 1 360 MET 360 623 623 MET MET A . n 
A 1 361 GLU 361 624 624 GLU GLU A . n 
A 1 362 GLY 362 625 625 GLY GLY A . n 
A 1 363 GLU 363 626 626 GLU GLU A . n 
A 1 364 GLY 364 627 627 GLY GLY A . n 
A 1 365 VAL 365 628 628 VAL VAL A . n 
A 1 366 PHE 366 629 629 PHE PHE A . n 
A 1 367 LYS 367 630 630 LYS LYS A . n 
A 1 368 SER 368 631 631 SER SER A . n 
A 1 369 ILE 369 632 632 ILE ILE A . n 
A 1 370 GLN 370 633 633 GLN GLN A . n 
A 1 371 HIS 371 634 634 HIS HIS A . n 
A 1 372 LEU 372 635 635 LEU LEU A . n 
A 1 373 THR 373 636 636 THR THR A . n 
A 1 374 VAL 374 637 637 VAL VAL A . n 
A 1 375 THR 375 638 638 THR THR A . n 
A 1 376 GLU 376 639 639 GLU GLU A . n 
A 1 377 GLU 377 640 640 GLU GLU A . n 
A 1 378 ILE 378 641 641 ILE ILE A . n 
A 1 379 ALA 379 642 642 ALA ALA A . n 
A 1 380 VAL 380 643 643 VAL VAL A . n 
A 1 381 LYS 381 644 644 LYS LYS A . n 
A 1 382 ASN 382 645 645 ASN ASN A . n 
A 1 383 TRP 383 646 646 TRP TRP A . n 
A 1 384 LEU 384 647 647 LEU LEU A . n 
A 1 385 VAL 385 648 648 VAL VAL A . n 
A 1 386 ARG 386 649 649 ARG ARG A . n 
A 1 387 VAL 387 650 650 VAL VAL A . n 
A 1 388 GLY 388 651 651 GLY GLY A . n 
A 1 389 ARG 389 652 652 ARG ARG A . n 
A 1 390 GLU 390 653 653 GLU GLU A . n 
A 1 391 ARG 391 654 654 ARG ARG A . n 
A 1 392 LEU 392 655 655 LEU LEU A . n 
A 1 393 SER 393 656 656 SER SER A . n 
A 1 394 ARG 394 657 657 ARG ARG A . n 
A 1 395 MET 395 658 658 MET MET A . n 
A 1 396 ALA 396 659 659 ALA ALA A . n 
A 1 397 ILE 397 660 660 ILE ILE A . n 
A 1 398 SER 398 661 661 SER SER A . n 
A 1 399 GLY 399 662 662 GLY GLY A . n 
A 1 400 ASP 400 663 663 ASP ASP A . n 
A 1 401 ASP 401 664 664 ASP ASP A . n 
A 1 402 CYS 402 665 665 CYS CYS A . n 
A 1 403 VAL 403 666 666 VAL VAL A . n 
A 1 404 VAL 404 667 667 VAL VAL A . n 
A 1 405 LYS 405 668 668 LYS LYS A . n 
A 1 406 PRO 406 669 669 PRO PRO A . n 
A 1 407 LEU 407 670 670 LEU LEU A . n 
A 1 408 ASP 408 671 671 ASP ASP A . n 
A 1 409 ASP 409 672 672 ASP ASP A . n 
A 1 410 ARG 410 673 673 ARG ARG A . n 
A 1 411 PHE 411 674 674 PHE PHE A . n 
A 1 412 ALA 412 675 675 ALA ALA A . n 
A 1 413 SER 413 676 676 SER SER A . n 
A 1 414 ALA 414 677 677 ALA ALA A . n 
A 1 415 LEU 415 678 678 LEU LEU A . n 
A 1 416 THR 416 679 679 THR THR A . n 
A 1 417 ALA 417 680 680 ALA ALA A . n 
A 1 418 LEU 418 681 681 LEU LEU A . n 
A 1 419 ASN 419 682 682 ASN ASN A . n 
A 1 420 ASP 420 683 683 ASP ASP A . n 
A 1 421 MET 421 684 684 MET MET A . n 
A 1 422 GLY 422 685 685 GLY GLY A . n 
A 1 423 LYS 423 686 686 LYS LYS A . n 
A 1 424 VAL 424 687 687 VAL VAL A . n 
A 1 425 ARG 425 688 688 ARG ARG A . n 
A 1 426 LYS 426 689 689 LYS LYS A . n 
A 1 427 ASP 427 690 690 ASP ASP A . n 
A 1 428 ILE 428 691 691 ILE ILE A . n 
A 1 429 GLN 429 692 692 GLN GLN A . n 
A 1 430 GLN 430 693 693 GLN GLN A . n 
A 1 431 TRP 431 694 694 TRP TRP A . n 
A 1 432 GLU 432 695 695 GLU GLU A . n 
A 1 433 PRO 433 696 696 PRO PRO A . n 
A 1 434 SER 434 697 697 SER SER A . n 
A 1 435 ARG 435 698 698 ARG ARG A . n 
A 1 436 GLY 436 699 699 GLY GLY A . n 
A 1 437 TRP 437 700 700 TRP TRP A . n 
A 1 438 ASN 438 701 701 ASN ASN A . n 
A 1 439 ASP 439 702 702 ASP ASP A . n 
A 1 440 TRP 440 703 703 TRP TRP A . n 
A 1 441 THR 441 704 704 THR THR A . n 
A 1 442 GLN 442 705 705 GLN GLN A . n 
A 1 443 VAL 443 706 706 VAL VAL A . n 
A 1 444 PRO 444 707 707 PRO PRO A . n 
A 1 445 PHE 445 708 708 PHE PHE A . n 
A 1 446 CYS 446 709 709 CYS CYS A . n 
A 1 447 SER 447 710 710 SER SER A . n 
A 1 448 HIS 448 711 711 HIS HIS A . n 
A 1 449 HIS 449 712 712 HIS HIS A . n 
A 1 450 PHE 450 713 713 PHE PHE A . n 
A 1 451 HIS 451 714 714 HIS HIS A . n 
A 1 452 GLU 452 715 715 GLU GLU A . n 
A 1 453 LEU 453 716 716 LEU LEU A . n 
A 1 454 ILE 454 717 717 ILE ILE A . n 
A 1 455 MET 455 718 718 MET MET A . n 
A 1 456 LYS 456 719 719 LYS LYS A . n 
A 1 457 ASP 457 720 720 ASP ASP A . n 
A 1 458 GLY 458 721 721 GLY GLY A . n 
A 1 459 ARG 459 722 722 ARG ARG A . n 
A 1 460 VAL 460 723 723 VAL VAL A . n 
A 1 461 LEU 461 724 724 LEU LEU A . n 
A 1 462 VAL 462 725 725 VAL VAL A . n 
A 1 463 VAL 463 726 726 VAL VAL A . n 
A 1 464 PRO 464 727 727 PRO PRO A . n 
A 1 465 CYS 465 728 728 CYS CYS A . n 
A 1 466 ARG 466 729 729 ARG ARG A . n 
A 1 467 ASN 467 730 730 ASN ASN A . n 
A 1 468 GLN 468 731 731 GLN GLN A . n 
A 1 469 ASP 469 732 732 ASP ASP A . n 
A 1 470 GLU 470 733 733 GLU GLU A . n 
A 1 471 LEU 471 734 734 LEU LEU A . n 
A 1 472 ILE 472 735 735 ILE ILE A . n 
A 1 473 GLY 473 736 736 GLY GLY A . n 
A 1 474 ARG 474 737 737 ARG ARG A . n 
A 1 475 ALA 475 738 738 ALA ALA A . n 
A 1 476 ARG 476 739 739 ARG ARG A . n 
A 1 477 ILE 477 740 740 ILE ILE A . n 
A 1 478 SER 478 741 741 SER SER A . n 
A 1 479 GLN 479 742 742 GLN GLN A . n 
A 1 480 GLY 480 743 743 GLY GLY A . n 
A 1 481 ALA 481 744 744 ALA ALA A . n 
A 1 482 GLY 482 745 745 GLY GLY A . n 
A 1 483 TRP 483 746 746 TRP TRP A . n 
A 1 484 SER 484 747 747 SER SER A . n 
A 1 485 LEU 485 748 748 LEU LEU A . n 
A 1 486 ARG 486 749 749 ARG ARG A . n 
A 1 487 GLU 487 750 750 GLU GLU A . n 
A 1 488 THR 488 751 751 THR THR A . n 
A 1 489 ALA 489 752 752 ALA ALA A . n 
A 1 490 CYS 490 753 753 CYS CYS A . n 
A 1 491 LEU 491 754 754 LEU LEU A . n 
A 1 492 GLY 492 755 755 GLY GLY A . n 
A 1 493 LYS 493 756 756 LYS LYS A . n 
A 1 494 SER 494 757 757 SER SER A . n 
A 1 495 TYR 495 758 758 TYR TYR A . n 
A 1 496 ALA 496 759 759 ALA ALA A . n 
A 1 497 GLN 497 760 760 GLN GLN A . n 
A 1 498 MET 498 761 761 MET MET A . n 
A 1 499 TRP 499 762 762 TRP TRP A . n 
A 1 500 SER 500 763 763 SER SER A . n 
A 1 501 LEU 501 764 764 LEU LEU A . n 
A 1 502 MET 502 765 765 MET MET A . n 
A 1 503 TYR 503 766 766 TYR TYR A . n 
A 1 504 PHE 504 767 767 PHE PHE A . n 
A 1 505 HIS 505 768 768 HIS HIS A . n 
A 1 506 ARG 506 769 769 ARG ARG A . n 
A 1 507 ARG 507 770 770 ARG ARG A . n 
A 1 508 ASP 508 771 771 ASP ASP A . n 
A 1 509 LEU 509 772 772 LEU LEU A . n 
A 1 510 ARG 510 773 773 ARG ARG A . n 
A 1 511 LEU 511 774 774 LEU LEU A . n 
A 1 512 ALA 512 775 775 ALA ALA A . n 
A 1 513 ALA 513 776 776 ALA ALA A . n 
A 1 514 ASN 514 777 777 ASN ASN A . n 
A 1 515 ALA 515 778 778 ALA ALA A . n 
A 1 516 ILE 516 779 779 ILE ILE A . n 
A 1 517 CYS 517 780 780 CYS CYS A . n 
A 1 518 SER 518 781 781 SER SER A . n 
A 1 519 ALA 519 782 782 ALA ALA A . n 
A 1 520 VAL 520 783 783 VAL VAL A . n 
A 1 521 PRO 521 784 784 PRO PRO A . n 
A 1 522 SER 522 785 785 SER SER A . n 
A 1 523 HIS 523 786 786 HIS HIS A . n 
A 1 524 TRP 524 787 787 TRP TRP A . n 
A 1 525 VAL 525 788 788 VAL VAL A . n 
A 1 526 PRO 526 789 789 PRO PRO A . n 
A 1 527 THR 527 790 790 THR THR A . n 
A 1 528 SER 528 791 791 SER SER A . n 
A 1 529 ARG 529 792 792 ARG ARG A . n 
A 1 530 THR 530 793 ?   ?   ?   A . n 
A 1 531 THR 531 794 ?   ?   ?   A . n 
A 1 532 TRP 532 795 ?   ?   ?   A . n 
A 1 533 SER 533 796 ?   ?   ?   A . n 
A 1 534 ILE 534 797 ?   ?   ?   A . n 
A 1 535 HIS 535 798 ?   ?   ?   A . n 
A 1 536 ALA 536 799 799 ALA ALA A . n 
A 1 537 THR 537 800 800 THR THR A . n 
A 1 538 HIS 538 801 801 HIS HIS A . n 
A 1 539 GLU 539 802 802 GLU GLU A . n 
A 1 540 TRP 540 803 803 TRP TRP A . n 
A 1 541 MET 541 804 804 MET MET A . n 
A 1 542 THR 542 805 805 THR THR A . n 
A 1 543 THR 543 806 806 THR THR A . n 
A 1 544 GLU 544 807 807 GLU GLU A . n 
A 1 545 ASP 545 808 808 ASP ASP A . n 
A 1 546 MET 546 809 809 MET MET A . n 
A 1 547 LEU 547 810 810 LEU LEU A . n 
A 1 548 THR 548 811 811 THR THR A . n 
A 1 549 VAL 549 812 812 VAL VAL A . n 
A 1 550 TRP 550 813 813 TRP TRP A . n 
A 1 551 ASN 551 814 814 ASN ASN A . n 
A 1 552 ARG 552 815 815 ARG ARG A . n 
A 1 553 VAL 553 816 816 VAL VAL A . n 
A 1 554 TRP 554 817 817 TRP TRP A . n 
A 1 555 ILE 555 818 818 ILE ILE A . n 
A 1 556 GLN 556 819 819 GLN GLN A . n 
A 1 557 GLU 557 820 820 GLU GLU A . n 
A 1 558 ASN 558 821 821 ASN ASN A . n 
A 1 559 PRO 559 822 822 PRO PRO A . n 
A 1 560 TRP 560 823 823 TRP TRP A . n 
A 1 561 MET 561 824 824 MET MET A . n 
A 1 562 GLU 562 825 825 GLU GLU A . n 
A 1 563 ASP 563 826 826 ASP ASP A . n 
A 1 564 LYS 564 827 827 LYS LYS A . n 
A 1 565 THR 565 828 828 THR THR A . n 
A 1 566 PRO 566 829 829 PRO PRO A . n 
A 1 567 VAL 567 830 830 VAL VAL A . n 
A 1 568 GLU 568 831 831 GLU GLU A . n 
A 1 569 SER 569 832 832 SER SER A . n 
A 1 570 TRP 570 833 833 TRP TRP A . n 
A 1 571 GLU 571 834 834 GLU GLU A . n 
A 1 572 GLU 572 835 835 GLU GLU A . n 
A 1 573 ILE 573 836 836 ILE ILE A . n 
A 1 574 PRO 574 837 837 PRO PRO A . n 
A 1 575 TYR 575 838 838 TYR TYR A . n 
A 1 576 LEU 576 839 839 LEU LEU A . n 
A 1 577 GLY 577 840 840 GLY GLY A . n 
A 1 578 LYS 578 841 841 LYS LYS A . n 
A 1 579 ARG 579 842 842 ARG ARG A . n 
A 1 580 GLU 580 843 843 GLU GLU A . n 
A 1 581 ASP 581 844 844 ASP ASP A . n 
A 1 582 GLN 582 845 845 GLN GLN A . n 
A 1 583 TRP 583 846 846 TRP TRP A . n 
A 1 584 CYS 584 847 847 CYS CYS A . n 
A 1 585 GLY 585 848 848 GLY GLY A . n 
A 1 586 SER 586 849 849 SER SER A . n 
A 1 587 LEU 587 850 850 LEU LEU A . n 
A 1 588 ILE 588 851 851 ILE ILE A . n 
A 1 589 GLY 589 852 852 GLY GLY A . n 
A 1 590 LEU 590 853 853 LEU LEU A . n 
A 1 591 THR 591 854 854 THR THR A . n 
A 1 592 SER 592 855 855 SER SER A . n 
A 1 593 ARG 593 856 856 ARG ARG A . n 
A 1 594 ALA 594 857 857 ALA ALA A . n 
A 1 595 THR 595 858 858 THR THR A . n 
A 1 596 TRP 596 859 859 TRP TRP A . n 
A 1 597 ALA 597 860 860 ALA ALA A . n 
A 1 598 LYS 598 861 861 LYS LYS A . n 
A 1 599 ASN 599 862 862 ASN ASN A . n 
A 1 600 ILE 600 863 863 ILE ILE A . n 
A 1 601 GLN 601 864 864 GLN GLN A . n 
A 1 602 THR 602 865 865 THR THR A . n 
A 1 603 ALA 603 866 866 ALA ALA A . n 
A 1 604 ILE 604 867 867 ILE ILE A . n 
A 1 605 ASN 605 868 868 ASN ASN A . n 
A 1 606 GLN 606 869 869 GLN GLN A . n 
A 1 607 VAL 607 870 870 VAL VAL A . n 
A 1 608 ARG 608 871 871 ARG ARG A . n 
A 1 609 SER 609 872 872 SER SER A . n 
A 1 610 LEU 610 873 873 LEU LEU A . n 
A 1 611 ILE 611 874 874 ILE ILE A . n 
A 1 612 GLY 612 875 875 GLY GLY A . n 
A 1 613 ASN 613 876 876 ASN ASN A . n 
A 1 614 GLU 614 877 877 GLU GLU A . n 
A 1 615 GLU 615 878 878 GLU GLU A . n 
A 1 616 TYR 616 879 879 TYR TYR A . n 
A 1 617 THR 617 880 880 THR THR A . n 
A 1 618 ASP 618 881 881 ASP ASP A . n 
A 1 619 TYR 619 882 882 TYR TYR A . n 
A 1 620 MET 620 883 883 MET MET A . n 
A 1 621 PRO 621 884 884 PRO PRO A . n 
A 1 622 SER 622 885 885 SER SER A . n 
A 1 623 MET 623 886 886 MET MET A . n 
A 1 624 LYS 624 887 887 LYS LYS A . n 
A 1 625 ARG 625 888 888 ARG ARG A . n 
A 1 626 PHE 626 889 889 PHE PHE A . n 
A 1 627 ARG 627 890 890 ARG ARG A . n 
A 1 628 ARG 628 891 891 ARG ARG A . n 
A 1 629 GLU 629 892 ?   ?   ?   A . n 
A 1 630 GLU 630 893 ?   ?   ?   A . n 
A 1 631 GLU 631 894 ?   ?   ?   A . n 
A 1 632 GLU 632 895 ?   ?   ?   A . n 
A 1 633 ALA 633 896 ?   ?   ?   A . n 
A 1 634 GLY 634 897 ?   ?   ?   A . n 
A 1 635 VAL 635 898 ?   ?   ?   A . n 
A 1 636 LEU 636 899 ?   ?   ?   A . n 
A 1 637 TRP 637 900 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        O0J 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   O0J 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 ZN  1   1001 1001 ZN  ZN  A . 
C 2 ZN  1   1002 1002 ZN  ZN  A . 
D 3 MES 1   1003 1004 MES MES A . 
E 4 DMS 1   1004 1530 DMS DMS A . 
F 4 DMS 1   1005 1602 DMS DMS A . 
G 5 PEG 1   1006 1603 PEG PEG A . 
H 6 PO4 1   1007 1604 PO4 PO4 A . 
I 6 PO4 1   1008 1606 PO4 PO4 A . 
J 5 PEG 1   1009 1607 PEG PEG A . 
K 7 O0J 1   1010 1707 O0J LIG A . 
L 8 CL  1   1011 1    CL  CL  A . 
M 9 HOH 1   1101 235  HOH HOH A . 
M 9 HOH 2   1102 152  HOH HOH A . 
M 9 HOH 3   1103 219  HOH HOH A . 
M 9 HOH 4   1104 189  HOH HOH A . 
M 9 HOH 5   1105 466  HOH HOH A . 
M 9 HOH 6   1106 259  HOH HOH A . 
M 9 HOH 7   1107 85   HOH HOH A . 
M 9 HOH 8   1108 273  HOH HOH A . 
M 9 HOH 9   1109 464  HOH HOH A . 
M 9 HOH 10  1110 58   HOH HOH A . 
M 9 HOH 11  1111 395  HOH HOH A . 
M 9 HOH 12  1112 191  HOH HOH A . 
M 9 HOH 13  1113 187  HOH HOH A . 
M 9 HOH 14  1114 226  HOH HOH A . 
M 9 HOH 15  1115 408  HOH HOH A . 
M 9 HOH 16  1116 92   HOH HOH A . 
M 9 HOH 17  1117 204  HOH HOH A . 
M 9 HOH 18  1118 216  HOH HOH A . 
M 9 HOH 19  1119 175  HOH HOH A . 
M 9 HOH 20  1120 250  HOH HOH A . 
M 9 HOH 21  1121 34   HOH HOH A . 
M 9 HOH 22  1122 201  HOH HOH A . 
M 9 HOH 23  1123 225  HOH HOH A . 
M 9 HOH 24  1124 251  HOH HOH A . 
M 9 HOH 25  1125 35   HOH HOH A . 
M 9 HOH 26  1126 185  HOH HOH A . 
M 9 HOH 27  1127 176  HOH HOH A . 
M 9 HOH 28  1128 148  HOH HOH A . 
M 9 HOH 29  1129 280  HOH HOH A . 
M 9 HOH 30  1130 7    HOH HOH A . 
M 9 HOH 31  1131 267  HOH HOH A . 
M 9 HOH 32  1132 312  HOH HOH A . 
M 9 HOH 33  1133 195  HOH HOH A . 
M 9 HOH 34  1134 291  HOH HOH A . 
M 9 HOH 35  1135 212  HOH HOH A . 
M 9 HOH 36  1136 363  HOH HOH A . 
M 9 HOH 37  1137 214  HOH HOH A . 
M 9 HOH 38  1138 151  HOH HOH A . 
M 9 HOH 39  1139 209  HOH HOH A . 
M 9 HOH 40  1140 230  HOH HOH A . 
M 9 HOH 41  1141 3    HOH HOH A . 
M 9 HOH 42  1142 311  HOH HOH A . 
M 9 HOH 43  1143 343  HOH HOH A . 
M 9 HOH 44  1144 239  HOH HOH A . 
M 9 HOH 45  1145 6    HOH HOH A . 
M 9 HOH 46  1146 25   HOH HOH A . 
M 9 HOH 47  1147 207  HOH HOH A . 
M 9 HOH 48  1148 376  HOH HOH A . 
M 9 HOH 49  1149 258  HOH HOH A . 
M 9 HOH 50  1150 186  HOH HOH A . 
M 9 HOH 51  1151 471  HOH HOH A . 
M 9 HOH 52  1152 196  HOH HOH A . 
M 9 HOH 53  1153 345  HOH HOH A . 
M 9 HOH 54  1154 210  HOH HOH A . 
M 9 HOH 55  1155 265  HOH HOH A . 
M 9 HOH 56  1156 5    HOH HOH A . 
M 9 HOH 57  1157 206  HOH HOH A . 
M 9 HOH 58  1158 4    HOH HOH A . 
M 9 HOH 59  1159 227  HOH HOH A . 
M 9 HOH 60  1160 242  HOH HOH A . 
M 9 HOH 61  1161 177  HOH HOH A . 
M 9 HOH 62  1162 180  HOH HOH A . 
M 9 HOH 63  1163 140  HOH HOH A . 
M 9 HOH 64  1164 16   HOH HOH A . 
M 9 HOH 65  1165 252  HOH HOH A . 
M 9 HOH 66  1166 188  HOH HOH A . 
M 9 HOH 67  1167 288  HOH HOH A . 
M 9 HOH 68  1168 458  HOH HOH A . 
M 9 HOH 69  1169 202  HOH HOH A . 
M 9 HOH 70  1170 300  HOH HOH A . 
M 9 HOH 71  1171 2    HOH HOH A . 
M 9 HOH 72  1172 306  HOH HOH A . 
M 9 HOH 73  1173 346  HOH HOH A . 
M 9 HOH 74  1174 277  HOH HOH A . 
M 9 HOH 75  1175 165  HOH HOH A . 
M 9 HOH 76  1176 470  HOH HOH A . 
M 9 HOH 77  1177 222  HOH HOH A . 
M 9 HOH 78  1178 319  HOH HOH A . 
M 9 HOH 79  1179 215  HOH HOH A . 
M 9 HOH 80  1180 334  HOH HOH A . 
M 9 HOH 81  1181 233  HOH HOH A . 
M 9 HOH 82  1182 380  HOH HOH A . 
M 9 HOH 83  1183 396  HOH HOH A . 
M 9 HOH 84  1184 424  HOH HOH A . 
M 9 HOH 85  1185 261  HOH HOH A . 
M 9 HOH 86  1186 190  HOH HOH A . 
M 9 HOH 87  1187 272  HOH HOH A . 
M 9 HOH 88  1188 52   HOH HOH A . 
M 9 HOH 89  1189 274  HOH HOH A . 
M 9 HOH 90  1190 205  HOH HOH A . 
M 9 HOH 91  1191 294  HOH HOH A . 
M 9 HOH 92  1192 96   HOH HOH A . 
M 9 HOH 93  1193 423  HOH HOH A . 
M 9 HOH 94  1194 199  HOH HOH A . 
M 9 HOH 95  1195 247  HOH HOH A . 
M 9 HOH 96  1196 281  HOH HOH A . 
M 9 HOH 97  1197 218  HOH HOH A . 
M 9 HOH 98  1198 220  HOH HOH A . 
M 9 HOH 99  1199 240  HOH HOH A . 
M 9 HOH 100 1200 296  HOH HOH A . 
M 9 HOH 101 1201 303  HOH HOH A . 
M 9 HOH 102 1202 243  HOH HOH A . 
M 9 HOH 103 1203 198  HOH HOH A . 
M 9 HOH 104 1204 290  HOH HOH A . 
M 9 HOH 105 1205 211  HOH HOH A . 
M 9 HOH 106 1206 18   HOH HOH A . 
M 9 HOH 107 1207 10   HOH HOH A . 
M 9 HOH 108 1208 11   HOH HOH A . 
M 9 HOH 109 1209 213  HOH HOH A . 
M 9 HOH 110 1210 315  HOH HOH A . 
M 9 HOH 111 1211 276  HOH HOH A . 
M 9 HOH 112 1212 203  HOH HOH A . 
M 9 HOH 113 1213 275  HOH HOH A . 
M 9 HOH 114 1214 338  HOH HOH A . 
M 9 HOH 115 1215 260  HOH HOH A . 
M 9 HOH 116 1216 266  HOH HOH A . 
M 9 HOH 117 1217 305  HOH HOH A . 
M 9 HOH 118 1218 320  HOH HOH A . 
M 9 HOH 119 1219 217  HOH HOH A . 
M 9 HOH 120 1220 194  HOH HOH A . 
M 9 HOH 121 1221 308  HOH HOH A . 
M 9 HOH 122 1222 333  HOH HOH A . 
M 9 HOH 123 1223 232  HOH HOH A . 
M 9 HOH 124 1224 392  HOH HOH A . 
M 9 HOH 125 1225 268  HOH HOH A . 
M 9 HOH 126 1226 292  HOH HOH A . 
M 9 HOH 127 1227 244  HOH HOH A . 
M 9 HOH 128 1228 249  HOH HOH A . 
M 9 HOH 129 1229 236  HOH HOH A . 
M 9 HOH 130 1230 120  HOH HOH A . 
M 9 HOH 131 1231 245  HOH HOH A . 
M 9 HOH 132 1232 89   HOH HOH A . 
M 9 HOH 133 1233 197  HOH HOH A . 
M 9 HOH 134 1234 328  HOH HOH A . 
M 9 HOH 135 1235 223  HOH HOH A . 
M 9 HOH 136 1236 221  HOH HOH A . 
M 9 HOH 137 1237 313  HOH HOH A . 
M 9 HOH 138 1238 27   HOH HOH A . 
M 9 HOH 139 1239 19   HOH HOH A . 
M 9 HOH 140 1240 182  HOH HOH A . 
M 9 HOH 141 1241 286  HOH HOH A . 
M 9 HOH 142 1242 285  HOH HOH A . 
M 9 HOH 143 1243 184  HOH HOH A . 
M 9 HOH 144 1244 193  HOH HOH A . 
M 9 HOH 145 1245 351  HOH HOH A . 
M 9 HOH 146 1246 224  HOH HOH A . 
M 9 HOH 147 1247 329  HOH HOH A . 
M 9 HOH 148 1248 39   HOH HOH A . 
M 9 HOH 149 1249 289  HOH HOH A . 
M 9 HOH 150 1250 237  HOH HOH A . 
M 9 HOH 151 1251 309  HOH HOH A . 
M 9 HOH 152 1252 234  HOH HOH A . 
M 9 HOH 153 1253 264  HOH HOH A . 
M 9 HOH 154 1254 269  HOH HOH A . 
M 9 HOH 155 1255 342  HOH HOH A . 
M 9 HOH 156 1256 304  HOH HOH A . 
M 9 HOH 157 1257 356  HOH HOH A . 
M 9 HOH 158 1258 56   HOH HOH A . 
M 9 HOH 159 1259 325  HOH HOH A . 
M 9 HOH 160 1260 282  HOH HOH A . 
M 9 HOH 161 1261 262  HOH HOH A . 
M 9 HOH 162 1262 298  HOH HOH A . 
M 9 HOH 163 1263 241  HOH HOH A . 
M 9 HOH 164 1264 257  HOH HOH A . 
M 9 HOH 165 1265 322  HOH HOH A . 
M 9 HOH 166 1266 238  HOH HOH A . 
M 9 HOH 167 1267 179  HOH HOH A . 
M 9 HOH 168 1268 278  HOH HOH A . 
M 9 HOH 169 1269 270  HOH HOH A . 
M 9 HOH 170 1270 323  HOH HOH A . 
M 9 HOH 171 1271 279  HOH HOH A . 
M 9 HOH 172 1272 339  HOH HOH A . 
M 9 HOH 173 1273 77   HOH HOH A . 
M 9 HOH 174 1274 368  HOH HOH A . 
M 9 HOH 175 1275 344  HOH HOH A . 
M 9 HOH 176 1276 378  HOH HOH A . 
M 9 HOH 177 1277 321  HOH HOH A . 
M 9 HOH 178 1278 302  HOH HOH A . 
M 9 HOH 179 1279 293  HOH HOH A . 
M 9 HOH 180 1280 355  HOH HOH A . 
M 9 HOH 181 1281 331  HOH HOH A . 
M 9 HOH 182 1282 381  HOH HOH A . 
M 9 HOH 183 1283 256  HOH HOH A . 
M 9 HOH 184 1284 371  HOH HOH A . 
M 9 HOH 185 1285 400  HOH HOH A . 
M 9 HOH 186 1286 82   HOH HOH A . 
M 9 HOH 187 1287 271  HOH HOH A . 
M 9 HOH 188 1288 284  HOH HOH A . 
M 9 HOH 189 1289 327  HOH HOH A . 
M 9 HOH 190 1290 330  HOH HOH A . 
M 9 HOH 191 1291 369  HOH HOH A . 
M 9 HOH 192 1292 110  HOH HOH A . 
M 9 HOH 193 1293 30   HOH HOH A . 
M 9 HOH 194 1294 352  HOH HOH A . 
M 9 HOH 195 1295 263  HOH HOH A . 
M 9 HOH 196 1296 316  HOH HOH A . 
M 9 HOH 197 1297 389  HOH HOH A . 
M 9 HOH 198 1298 377  HOH HOH A . 
M 9 HOH 199 1299 357  HOH HOH A . 
M 9 HOH 200 1300 399  HOH HOH A . 
M 9 HOH 201 1301 57   HOH HOH A . 
M 9 HOH 202 1302 326  HOH HOH A . 
M 9 HOH 203 1303 360  HOH HOH A . 
M 9 HOH 204 1304 33   HOH HOH A . 
M 9 HOH 205 1305 24   HOH HOH A . 
M 9 HOH 206 1306 314  HOH HOH A . 
M 9 HOH 207 1307 122  HOH HOH A . 
M 9 HOH 208 1308 136  HOH HOH A . 
M 9 HOH 209 1309 14   HOH HOH A . 
M 9 HOH 210 1310 366  HOH HOH A . 
M 9 HOH 211 1311 335  HOH HOH A . 
M 9 HOH 212 1312 388  HOH HOH A . 
M 9 HOH 213 1313 318  HOH HOH A . 
M 9 HOH 214 1314 361  HOH HOH A . 
M 9 HOH 215 1315 67   HOH HOH A . 
M 9 HOH 216 1316 231  HOH HOH A . 
M 9 HOH 217 1317 297  HOH HOH A . 
M 9 HOH 218 1318 384  HOH HOH A . 
M 9 HOH 219 1319 461  HOH HOH A . 
M 9 HOH 220 1320 46   HOH HOH A . 
M 9 HOH 221 1321 143  HOH HOH A . 
M 9 HOH 222 1322 134  HOH HOH A . 
M 9 HOH 223 1323 469  HOH HOH A . 
M 9 HOH 224 1324 38   HOH HOH A . 
M 9 HOH 225 1325 100  HOH HOH A . 
M 9 HOH 226 1326 394  HOH HOH A . 
M 9 HOH 227 1327 42   HOH HOH A . 
M 9 HOH 228 1328 26   HOH HOH A . 
M 9 HOH 229 1329 367  HOH HOH A . 
M 9 HOH 230 1330 365  HOH HOH A . 
M 9 HOH 231 1331 109  HOH HOH A . 
M 9 HOH 232 1332 421  HOH HOH A . 
M 9 HOH 233 1333 444  HOH HOH A . 
M 9 HOH 234 1334 379  HOH HOH A . 
M 9 HOH 235 1335 451  HOH HOH A . 
M 9 HOH 236 1336 404  HOH HOH A . 
M 9 HOH 237 1337 410  HOH HOH A . 
M 9 HOH 238 1338 393  HOH HOH A . 
M 9 HOH 239 1339 32   HOH HOH A . 
M 9 HOH 240 1340 132  HOH HOH A . 
M 9 HOH 241 1341 1    HOH HOH A . 
M 9 HOH 242 1342 406  HOH HOH A . 
M 9 HOH 243 1343 248  HOH HOH A . 
M 9 HOH 244 1344 402  HOH HOH A . 
M 9 HOH 245 1345 283  HOH HOH A . 
M 9 HOH 246 1346 364  HOH HOH A . 
M 9 HOH 247 1347 405  HOH HOH A . 
M 9 HOH 248 1348 340  HOH HOH A . 
M 9 HOH 249 1349 354  HOH HOH A . 
M 9 HOH 250 1350 387  HOH HOH A . 
M 9 HOH 251 1351 101  HOH HOH A . 
M 9 HOH 252 1352 80   HOH HOH A . 
M 9 HOH 253 1353 83   HOH HOH A . 
M 9 HOH 254 1354 383  HOH HOH A . 
M 9 HOH 255 1355 138  HOH HOH A . 
M 9 HOH 256 1356 13   HOH HOH A . 
M 9 HOH 257 1357 411  HOH HOH A . 
M 9 HOH 258 1358 348  HOH HOH A . 
M 9 HOH 259 1359 391  HOH HOH A . 
M 9 HOH 260 1360 116  HOH HOH A . 
M 9 HOH 261 1361 390  HOH HOH A . 
M 9 HOH 262 1362 347  HOH HOH A . 
M 9 HOH 263 1363 374  HOH HOH A . 
M 9 HOH 264 1364 40   HOH HOH A . 
M 9 HOH 265 1365 106  HOH HOH A . 
M 9 HOH 266 1366 454  HOH HOH A . 
M 9 HOH 267 1367 419  HOH HOH A . 
M 9 HOH 268 1368 372  HOH HOH A . 
M 9 HOH 269 1369 48   HOH HOH A . 
M 9 HOH 270 1370 350  HOH HOH A . 
M 9 HOH 271 1371 91   HOH HOH A . 
M 9 HOH 272 1372 310  HOH HOH A . 
M 9 HOH 273 1373 398  HOH HOH A . 
M 9 HOH 274 1374 287  HOH HOH A . 
M 9 HOH 275 1375 63   HOH HOH A . 
M 9 HOH 276 1376 359  HOH HOH A . 
M 9 HOH 277 1377 98   HOH HOH A . 
M 9 HOH 278 1378 299  HOH HOH A . 
M 9 HOH 279 1379 253  HOH HOH A . 
M 9 HOH 280 1380 349  HOH HOH A . 
M 9 HOH 281 1381 97   HOH HOH A . 
M 9 HOH 282 1382 124  HOH HOH A . 
M 9 HOH 283 1383 353  HOH HOH A . 
M 9 HOH 284 1384 28   HOH HOH A . 
M 9 HOH 285 1385 452  HOH HOH A . 
M 9 HOH 286 1386 118  HOH HOH A . 
M 9 HOH 287 1387 246  HOH HOH A . 
M 9 HOH 288 1388 255  HOH HOH A . 
M 9 HOH 289 1389 412  HOH HOH A . 
M 9 HOH 290 1390 23   HOH HOH A . 
M 9 HOH 291 1391 413  HOH HOH A . 
M 9 HOH 292 1392 43   HOH HOH A . 
M 9 HOH 293 1393 409  HOH HOH A . 
M 9 HOH 294 1394 415  HOH HOH A . 
M 9 HOH 295 1395 131  HOH HOH A . 
M 9 HOH 296 1396 36   HOH HOH A . 
M 9 HOH 297 1397 181  HOH HOH A . 
M 9 HOH 298 1398 41   HOH HOH A . 
M 9 HOH 299 1399 467  HOH HOH A . 
M 9 HOH 300 1400 59   HOH HOH A . 
M 9 HOH 301 1401 429  HOH HOH A . 
M 9 HOH 302 1402 430  HOH HOH A . 
M 9 HOH 303 1403 426  HOH HOH A . 
M 9 HOH 304 1404 436  HOH HOH A . 
M 9 HOH 305 1405 159  HOH HOH A . 
M 9 HOH 306 1406 385  HOH HOH A . 
M 9 HOH 307 1407 437  HOH HOH A . 
M 9 HOH 308 1408 439  HOH HOH A . 
M 9 HOH 309 1409 324  HOH HOH A . 
M 9 HOH 310 1410 403  HOH HOH A . 
M 9 HOH 311 1411 123  HOH HOH A . 
M 9 HOH 312 1412 414  HOH HOH A . 
M 9 HOH 313 1413 51   HOH HOH A . 
M 9 HOH 314 1414 397  HOH HOH A . 
M 9 HOH 315 1415 168  HOH HOH A . 
M 9 HOH 316 1416 432  HOH HOH A . 
M 9 HOH 317 1417 94   HOH HOH A . 
M 9 HOH 318 1418 54   HOH HOH A . 
M 9 HOH 319 1419 115  HOH HOH A . 
M 9 HOH 320 1420 433  HOH HOH A . 
M 9 HOH 321 1421 69   HOH HOH A . 
M 9 HOH 322 1422 428  HOH HOH A . 
M 9 HOH 323 1423 44   HOH HOH A . 
M 9 HOH 324 1424 8    HOH HOH A . 
M 9 HOH 325 1425 435  HOH HOH A . 
M 9 HOH 326 1426 20   HOH HOH A . 
M 9 HOH 327 1427 53   HOH HOH A . 
M 9 HOH 328 1428 137  HOH HOH A . 
M 9 HOH 329 1429 425  HOH HOH A . 
M 9 HOH 330 1430 127  HOH HOH A . 
M 9 HOH 331 1431 157  HOH HOH A . 
M 9 HOH 332 1432 438  HOH HOH A . 
M 9 HOH 333 1433 61   HOH HOH A . 
M 9 HOH 334 1434 462  HOH HOH A . 
M 9 HOH 335 1435 121  HOH HOH A . 
M 9 HOH 336 1436 341  HOH HOH A . 
M 9 HOH 337 1437 441  HOH HOH A . 
M 9 HOH 338 1438 449  HOH HOH A . 
M 9 HOH 339 1439 445  HOH HOH A . 
M 9 HOH 340 1440 173  HOH HOH A . 
M 9 HOH 341 1441 448  HOH HOH A . 
M 9 HOH 342 1442 21   HOH HOH A . 
M 9 HOH 343 1443 440  HOH HOH A . 
M 9 HOH 344 1444 447  HOH HOH A . 
M 9 HOH 345 1445 64   HOH HOH A . 
M 9 HOH 346 1446 463  HOH HOH A . 
M 9 HOH 347 1447 49   HOH HOH A . 
M 9 HOH 348 1448 17   HOH HOH A . 
M 9 HOH 349 1449 73   HOH HOH A . 
M 9 HOH 350 1450 55   HOH HOH A . 
M 9 HOH 351 1451 468  HOH HOH A . 
M 9 HOH 352 1452 450  HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 A THR 344 ? CB  ? A THR 81 CB  
2 1 Y 1 A THR 344 ? OG1 ? A THR 81 OG1 
3 1 Y 1 A THR 344 ? CG2 ? A THR 81 CG2 
# 
loop_
_software.classification 
_software.name 
_software.version 
_software.citation_id 
_software.pdbx_ordinal 
_software.date 
_software.type 
_software.location 
_software.language 
refinement       REFMAC  5.8.0267 ? 1 ? ? ? ? 
refinement       REFMAC5 .        ? 2 ? ? ? ? 
'data scaling'   Aimless .        ? 3 ? ? ? ? 
phasing          PHASER  .        ? 4 ? ? ? ? 
'data reduction' XDS     .        ? 5 ? ? ? ? 
# 
_cell.entry_id           7I29 
_cell.length_a           82.275 
_cell.length_b           117.416 
_cell.length_c           148.916 
_cell.angle_alpha        90.00 
_cell.angle_beta         90.00 
_cell.angle_gamma        90.00 
_cell.Z_PDB              8 
_cell.pdbx_unique_axis   ? 
# 
_symmetry.entry_id                         7I29 
_symmetry.space_group_name_H-M             'I 2 2 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                23 
# 
_exptl.entry_id          7I29 
_exptl.method            'X-RAY DIFFRACTION' 
_exptl.crystals_number   1 
# 
_exptl_crystal.id                    1 
_exptl_crystal.density_meas          ? 
_exptl_crystal.density_Matthews      2.43 
_exptl_crystal.density_percent_sol   49.46 
_exptl_crystal.description           ? 
_exptl_crystal.preparation           ? 
# 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.pH              6.5 
_exptl_crystal_grow.temp            293.15 
_exptl_crystal_grow.pdbx_details    '350 mM Magnesium chloride, 10% PEG 4000, 100 mM MES, pH 6.5' 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.pdbx_pH_range   ? 
# 
_diffrn.id                               1 
_diffrn.ambient_temp                     100 
_diffrn.crystal_id                       1 
_diffrn.ambient_temp_details             ? 
_diffrn.pdbx_serial_crystal_experiment   ? 
# 
_diffrn_detector.detector               PIXEL 
_diffrn_detector.type                   'DECTRIS EIGER2 XE 9M' 
_diffrn_detector.pdbx_collection_date   2023-08-08 
_diffrn_detector.diffrn_id              1 
_diffrn_detector.details                ? 
# 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.92124 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.diffrn_id                   1 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.type                        'DIAMOND BEAMLINE I04-1' 
_diffrn_source.pdbx_wavelength_list        0.92124 
_diffrn_source.pdbx_synchrotron_site       Diamond 
_diffrn_source.pdbx_synchrotron_beamline   I04-1 
_diffrn_source.pdbx_wavelength             ? 
# 
_reflns.entry_id                     7I29 
_reflns.pdbx_diffrn_id               1 
_reflns.pdbx_ordinal                 1 
_reflns.d_resolution_low             74.47 
_reflns.d_resolution_high            1.50 
_reflns.number_obs                   114890 
_reflns.percent_possible_obs         99.8 
_reflns.pdbx_Rmerge_I_obs            0.143 
_reflns.pdbx_netI_over_sigmaI        8.5 
_reflns.pdbx_redundancy              11.9 
_reflns.pdbx_Rrim_I_all              0.149 
_reflns.pdbx_Rpim_I_all              0.043 
_reflns.pdbx_CC_half                 0.994 
_reflns.pdbx_number_measured_all     1362434 
_reflns.pdbx_chi_squared             0.69 
_reflns.observed_criterion_sigma_I   ? 
_reflns.observed_criterion_sigma_F   ? 
_reflns.number_all                   ? 
_reflns.pdbx_Rsym_value              ? 
_reflns.B_iso_Wilson_estimate        ? 
_reflns.pdbx_CC_star                 ? 
# 
_reflns_shell.pdbx_diffrn_id              1 
_reflns_shell.pdbx_ordinal                1 
_reflns_shell.d_res_high                  1.50 
_reflns_shell.d_res_low                   1.53 
_reflns_shell.number_measured_all         42722 
_reflns_shell.number_unique_obs           5606 
_reflns_shell.Rmerge_I_obs                ? 
_reflns_shell.pdbx_chi_squared            0.30 
_reflns_shell.pdbx_redundancy             7.6 
_reflns_shell.percent_possible_obs        98.9 
_reflns_shell.pdbx_netI_over_sigmaI_obs   -0.1 
_reflns_shell.pdbx_Rrim_I_all             ? 
_reflns_shell.pdbx_Rpim_I_all             ? 
_reflns_shell.pdbx_CC_half                0.346 
_reflns_shell.percent_possible_all        ? 
_reflns_shell.pdbx_Rsym_value             ? 
_reflns_shell.meanI_over_sigI_obs         ? 
_reflns_shell.number_measured_obs         ? 
_reflns_shell.number_unique_all           ? 
_reflns_shell.pdbx_CC_star                ? 
# 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.entry_id                                 7I29 
_refine.pdbx_diffrn_id                           1 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     103870 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             74.46 
_refine.ls_d_res_high                            1.50 
_refine.ls_percent_reflns_obs                    95.06 
_refine.ls_R_factor_obs                          0.25691 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       0.25506 
_refine.ls_R_factor_R_free                       0.29073 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 5.1 
_refine.ls_number_reflns_R_free                  5554 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               0.917 
_refine.correlation_coeff_Fo_to_Fc_free          0.884 
_refine.B_iso_mean                               52.681 
_refine.aniso_B[1][1]                            -3.12 
_refine.aniso_B[2][2]                            1.21 
_refine.aniso_B[3][3]                            1.91 
_refine.aniso_B[1][2]                            -0.00 
_refine.aniso_B[1][3]                            0.00 
_refine.aniso_B[2][3]                            -0.00 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             1.20 
_refine.pdbx_solvent_ion_probe_radii             0.80 
_refine.pdbx_solvent_shrinkage_radii             0.80 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.details                                  'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_overall_ESU_R                       0.185 
_refine.pdbx_overall_ESU_R_Free                  0.154 
_refine.overall_SU_ML                            0.211 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             7.016 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         1 
_refine_hist.pdbx_number_atoms_protein        4586 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         63 
_refine_hist.number_atoms_solvent             352 
_refine_hist.number_atoms_total               5001 
_refine_hist.d_res_high                       1.50 
_refine_hist.d_res_low                        74.46 
# 
loop_
_refine_ls_restr.type 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.weight 
_refine_ls_restr.number 
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.pdbx_restraint_function 
r_bond_refined_d             0.006  0.015  ? 16185 'X-RAY DIFFRACTION' ? 
r_bond_other_d               0.001  0.015  ? 10875 'X-RAY DIFFRACTION' ? 
r_angle_refined_deg          1.387  1.645  ? 15717 'X-RAY DIFFRACTION' ? 
r_angle_other_deg            1.214  1.592  ? 25092 'X-RAY DIFFRACTION' ? 
r_dihedral_angle_1_deg       6.343  5.000  ? 1418  'X-RAY DIFFRACTION' ? 
r_dihedral_angle_2_deg       29.243 21.062 ? 697   'X-RAY DIFFRACTION' ? 
r_dihedral_angle_3_deg       17.215 15.000 ? 2168  'X-RAY DIFFRACTION' ? 
r_dihedral_angle_4_deg       18.457 15.000 ? 114   'X-RAY DIFFRACTION' ? 
r_chiral_restr               0.064  0.200  ? 1410  'X-RAY DIFFRACTION' ? 
r_gen_planes_refined         0.007  0.020  ? 13454 'X-RAY DIFFRACTION' ? 
r_gen_planes_other           0.002  0.020  ? 2922  'X-RAY DIFFRACTION' ? 
r_nbd_refined                ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbd_other                  ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbtor_refined              ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbtor_other                ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_xyhbond_nbd_refined        ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_xyhbond_nbd_other          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_metal_ion_refined          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_metal_ion_other            ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_vdw_refined       ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_vdw_other         ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_hbond_refined     ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_hbond_other       ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_metal_ion_refined ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_metal_ion_other   ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_mcbond_it                  2.596  5.328  ? 7727  'X-RAY DIFFRACTION' ? 
r_mcbond_other               2.643  5.357  ? 7454  'X-RAY DIFFRACTION' ? 
r_mcangle_it                 4.988  7.643  ? 6936  'X-RAY DIFFRACTION' ? 
r_mcangle_other              4.990  7.646  ? 6931  'X-RAY DIFFRACTION' ? 
r_scbond_it                  2.460  5.809  ? 8458  'X-RAY DIFFRACTION' ? 
r_scbond_other               2.460  5.809  ? 8458  'X-RAY DIFFRACTION' ? 
r_scangle_it                 ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_scangle_other              4.386  8.334  ? 8778  'X-RAY DIFFRACTION' ? 
r_long_range_B_refined       7.358  35.949 ? 9532  'X-RAY DIFFRACTION' ? 
r_long_range_B_other         7.228  35.528 ? 9385  'X-RAY DIFFRACTION' ? 
r_rigid_bond_restr           ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_sphericity_free            ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_sphericity_bonded          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.d_res_high                       1.500 
_refine_ls_shell.d_res_low                        1.539 
_refine_ls_shell.number_reflns_R_work             5006 
_refine_ls_shell.R_factor_R_work                  0.836 
_refine_ls_shell.percent_reflns_obs               62.71 
_refine_ls_shell.R_factor_R_free                  0.846 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.number_reflns_R_free             279 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.number_reflns_obs                ? 
# 
_struct.entry_id                  7I29 
_struct.title                     
;Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 -- Crystal structure of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 in complex with Z48847594 (DNV2_NS5A-x0162)
;
_struct.pdbx_model_details        ? 
_struct.pdbx_CASP_flag            ? 
_struct.pdbx_model_type_details   ? 
# 
_struct_keywords.entry_id        7I29 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
_struct_keywords.text            
;Diamond Light Source, I04-1, READDI, Dengue Virus, crystallographic fragment screening, PanDDA, XChemExplorer, cluster4x, VIRAL PROTEIN
;
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 2 ? 
D N N 3 ? 
E N N 4 ? 
F N N 4 ? 
G N N 5 ? 
H N N 6 ? 
I N N 6 ? 
J N N 5 ? 
K N N 7 ? 
L N N 8 ? 
M N N 9 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    Q91H74_9FLAV 
_struct_ref.pdbx_db_accession          Q91H74 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;GIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAMTD
TTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAREA
VEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENSLS
GVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRPTP
RGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGDDC
VVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQGAG
WSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPWME
DKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_struct_ref.pdbx_align_begin           2757 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              7I29 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 3 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 637 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q91H74 
_struct_ref_seq.db_align_beg                  2757 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  3391 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       266 
_struct_ref_seq.pdbx_auth_seq_align_end       900 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 7I29 GLY A 1 ? UNP Q91H74 ? ? 'expression tag' 264 1 
1 7I29 PRO A 2 ? UNP Q91H74 ? ? 'expression tag' 265 2 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L,M 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASN A 10  ? GLU A 24  ? ASN A 273 GLU A 287 1 ? 15 
HELX_P HELX_P2  AA2 ASN A 59  ? LEU A 65  ? ASN A 322 LEU A 328 1 ? 7  
HELX_P HELX_P3  AA3 THR A 66  ? ILE A 71  ? THR A 329 ILE A 334 5 ? 6  
HELX_P HELX_P4  AA4 ILE A 72  ? GLN A 77  ? ILE A 335 GLN A 340 1 ? 6  
HELX_P HELX_P5  AA5 MET A 78  ? MET A 80  ? MET A 341 MET A 343 5 ? 3  
HELX_P HELX_P6  AA6 LYS A 104 ? LYS A 124 ? LYS A 367 LYS A 387 1 ? 21 
HELX_P HELX_P7  AA7 THR A 132 ? SER A 142 ? THR A 395 SER A 405 1 ? 11 
HELX_P HELX_P8  AA8 SER A 158 ? VAL A 163 ? SER A 421 VAL A 426 1 ? 6  
HELX_P HELX_P9  AA9 ASP A 165 ? GLU A 181 ? ASP A 428 GLU A 444 1 ? 17 
HELX_P HELX_P10 AB1 TRP A 215 ? GLY A 227 ? TRP A 478 GLY A 490 1 ? 13 
HELX_P HELX_P11 AB2 GLY A 227 ? ASP A 232 ? GLY A 490 ASP A 495 1 ? 6  
HELX_P HELX_P12 AB3 SER A 236 ? LEU A 241 ? SER A 499 LEU A 504 1 ? 6  
HELX_P HELX_P13 AB4 GLY A 248 ? LYS A 261 ? GLY A 511 LYS A 524 1 ? 14 
HELX_P HELX_P14 AB5 GLY A 274 ? ILE A 279 ? GLY A 537 ILE A 542 5 ? 6  
HELX_P HELX_P15 AB6 THR A 280 ? MET A 289 ? THR A 543 MET A 552 1 ? 10 
HELX_P HELX_P16 AB7 VAL A 290 ? MET A 294 ? VAL A 553 MET A 557 5 ? 5  
HELX_P HELX_P17 AB8 GLU A 295 ? TYR A 310 ? GLU A 558 TYR A 573 1 ? 16 
HELX_P HELX_P18 AB9 GLY A 339 ? GLU A 363 ? GLY A 602 GLU A 626 1 ? 25 
HELX_P HELX_P19 AC1 THR A 373 ? SER A 393 ? THR A 636 SER A 656 1 ? 21 
HELX_P HELX_P20 AC2 ASP A 408 ? ALA A 414 ? ASP A 671 ALA A 677 5 ? 7  
HELX_P HELX_P21 AC3 LEU A 415 ? MET A 421 ? LEU A 678 MET A 684 1 ? 7  
HELX_P HELX_P22 AC4 ASP A 439 ? VAL A 443 ? ASP A 702 VAL A 706 5 ? 5  
HELX_P HELX_P23 AC5 ASN A 467 ? ARG A 476 ? ASN A 730 ARG A 739 1 ? 10 
HELX_P HELX_P24 AC6 SER A 484 ? TYR A 503 ? SER A 747 TYR A 766 1 ? 20 
HELX_P HELX_P25 AC7 ARG A 506 ? VAL A 520 ? ARG A 769 VAL A 783 1 ? 15 
HELX_P HELX_P26 AC8 ASP A 545 ? ILE A 555 ? ASP A 808 ILE A 818 1 ? 11 
HELX_P HELX_P27 AC9 SER A 569 ? ILE A 573 ? SER A 832 ILE A 836 5 ? 5  
HELX_P HELX_P28 AD1 GLY A 577 ? CYS A 584 ? GLY A 840 CYS A 847 1 ? 8  
HELX_P HELX_P29 AD2 LEU A 590 ? ASN A 599 ? LEU A 853 ASN A 862 1 ? 10 
HELX_P HELX_P30 AD3 ASN A 599 ? GLY A 612 ? ASN A 862 GLY A 875 1 ? 14 
HELX_P HELX_P31 AD4 TYR A 619 ? ARG A 627 ? TYR A 882 ARG A 890 5 ? 9  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1 metalc ? ? A HIS 179 NE2 ? ? ? 1_555 C ZN . ZN ? ? A HIS 442 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.029 ? ? 
metalc2 metalc ? ? A CYS 184 SG  ? ? ? 1_555 C ZN . ZN ? ? A CYS 447 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.195 ? ? 
metalc3 metalc ? ? A CYS 187 SG  ? ? ? 1_555 C ZN . ZN ? ? A CYS 450 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.635 ? ? 
metalc4 metalc ? ? A HIS 449 NE2 ? ? ? 1_555 B ZN . ZN ? ? A HIS 712 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.071 ? ? 
metalc5 metalc ? ? A HIS 451 NE2 ? ? ? 1_555 B ZN . ZN ? ? A HIS 714 A ZN 1001 1_555 ? ? ? ? ? ? ? 1.982 ? ? 
metalc6 metalc ? ? A CYS 465 SG  ? ? ? 1_555 B ZN . ZN ? ? A CYS 728 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.365 ? ? 
metalc7 metalc ? ? A CYS 584 SG  ? ? ? 1_555 B ZN . ZN ? ? A CYS 847 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.295 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1 NE2 ? A HIS 179 ? A HIS 442 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 184 ? A CYS 447 ? 1_555 144.4 ? 
2 NE2 ? A HIS 179 ? A HIS 442 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 106.2 ? 
3 SG  ? A CYS 184 ? A CYS 447 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 103.1 ? 
4 NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 NE2 ? A HIS 451 ? A HIS 714 ? 1_555 102.3 ? 
5 NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 465 ? A CYS 728 ? 1_555 101.6 ? 
6 NE2 ? A HIS 451 ? A HIS 714 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 465 ? A CYS 728 ? 1_555 108.9 ? 
7 NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 107.0 ? 
8 NE2 ? A HIS 451 ? A HIS 714 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 116.3 ? 
9 SG  ? A CYS 465 ? A CYS 728 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 118.4 ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 2 ? 
AA3 ? 2 ? 
AA4 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? parallel      
AA1 4 5 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ALA A 41  ? SER A 45  ? ALA A 304 SER A 308 
AA1 2 ASP A 328 ? SER A 331 ? ASP A 591 SER A 594 
AA1 3 VAL A 315 ? VAL A 317 ? VAL A 578 VAL A 580 
AA1 4 TYR A 189 ? MET A 191 ? TYR A 452 MET A 454 
AA1 5 TRP A 212 ? TYR A 213 ? TRP A 475 TYR A 476 
AA2 1 SER A 56  ? VAL A 58  ? SER A 319 VAL A 321 
AA2 2 ILE A 477 ? GLN A 479 ? ILE A 740 GLN A 742 
AA3 1 MET A 395 ? SER A 398 ? MET A 658 SER A 661 
AA3 2 ASP A 401 ? VAL A 404 ? ASP A 664 VAL A 667 
AA4 1 HIS A 449 ? ILE A 454 ? HIS A 712 ILE A 717 
AA4 2 VAL A 460 ? CYS A 465 ? VAL A 723 CYS A 728 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N HIS A 43  ? N HIS A 306 O ILE A 329 ? O ILE A 592 
AA1 2 3 O ILE A 330 ? O ILE A 593 N VAL A 315 ? N VAL A 578 
AA1 3 4 O ARG A 316 ? O ARG A 579 N TYR A 189 ? N TYR A 452 
AA1 4 5 N ASN A 190 ? N ASN A 453 O TYR A 213 ? O TYR A 476 
AA2 1 2 N MET A 57  ? N MET A 320 O SER A 478 ? O SER A 741 
AA3 1 2 N SER A 398 ? N SER A 661 O ASP A 401 ? O ASP A 664 
AA4 1 2 N LEU A 453 ? N LEU A 716 O LEU A 461 ? O LEU A 724 
# 
_pdbx_entry_details.entry_id                   7I29 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 OD1 A ASP 664 ? ? O2 A PO4 1007 ? ? 1.99 
2 1 O   A ILE 276 ? ? O  A HOH 1102 ? ? 2.17 
# 
_pdbx_validate_rmsd_angle.id                         1 
_pdbx_validate_rmsd_angle.PDB_model_num              1 
_pdbx_validate_rmsd_angle.auth_atom_id_1             NE 
_pdbx_validate_rmsd_angle.auth_asym_id_1             A 
_pdbx_validate_rmsd_angle.auth_comp_id_1             ARG 
_pdbx_validate_rmsd_angle.auth_seq_id_1              815 
_pdbx_validate_rmsd_angle.PDB_ins_code_1             ? 
_pdbx_validate_rmsd_angle.label_alt_id_1             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_2             CZ 
_pdbx_validate_rmsd_angle.auth_asym_id_2             A 
_pdbx_validate_rmsd_angle.auth_comp_id_2             ARG 
_pdbx_validate_rmsd_angle.auth_seq_id_2              815 
_pdbx_validate_rmsd_angle.PDB_ins_code_2             ? 
_pdbx_validate_rmsd_angle.label_alt_id_2             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_3             NH2 
_pdbx_validate_rmsd_angle.auth_asym_id_3             A 
_pdbx_validate_rmsd_angle.auth_comp_id_3             ARG 
_pdbx_validate_rmsd_angle.auth_seq_id_3              815 
_pdbx_validate_rmsd_angle.PDB_ins_code_3             ? 
_pdbx_validate_rmsd_angle.label_alt_id_3             ? 
_pdbx_validate_rmsd_angle.angle_value                117.25 
_pdbx_validate_rmsd_angle.angle_target_value         120.30 
_pdbx_validate_rmsd_angle.angle_deviation            -3.05 
_pdbx_validate_rmsd_angle.angle_standard_deviation   0.50 
_pdbx_validate_rmsd_angle.linker_flag                N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 TRP A 292 ? ? -80.92  49.50   
2  1 LYS A 301 ? ? -123.17 -60.85  
3  1 SER A 405 ? ? -77.49  -159.42 
4  1 ALA A 408 ? ? -35.54  118.37  
5  1 GLU A 448 ? ? -137.03 -34.72  
6  1 LEU A 504 ? ? 74.32   -45.68  
7  1 GLN A 598 ? ? 75.64   153.48  
8  1 SER A 601 ? ? -127.12 -163.89 
9  1 ASP A 690 ? ? 85.22   33.63   
10 1 PRO A 884 ? ? -69.16  0.95    
11 1 ARG A 890 ? ? -96.58  56.84   
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A MES 1003 ? D MES . 
2 1 A HOH 1205 ? M HOH . 
3 1 A HOH 1316 ? M HOH . 
4 1 A HOH 1399 ? M HOH . 
5 1 A HOH 1432 ? M HOH . 
6 1 A HOH 1451 ? M HOH . 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 1451 ? 6.30 . 
2 1 O ? A HOH 1452 ? 6.49 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY 264 ? A GLY 1   
2  1 Y 1 A PRO 265 ? A PRO 2   
3  1 Y 1 A GLY 266 ? A GLY 3   
4  1 Y 1 A ILE 267 ? A ILE 4   
5  1 Y 1 A GLU 268 ? A GLU 5   
6  1 Y 1 A SER 269 ? A SER 6   
7  1 Y 1 A GLU 270 ? A GLU 7   
8  1 Y 1 A THR 271 ? A THR 8   
9  1 Y 1 A PRO 272 ? A PRO 9   
10 1 Y 1 A GLU 310 ? A GLU 47  
11 1 Y 1 A THR 311 ? A THR 48  
12 1 Y 1 A LYS 312 ? A LYS 49  
13 1 Y 1 A GLN 313 ? A GLN 50  
14 1 Y 1 A THR 314 ? A THR 51  
15 1 Y 1 A GLY 315 ? A GLY 52  
16 1 Y 1 A SER 316 ? A SER 53  
17 1 Y 1 A ALA 317 ? A ALA 54  
18 1 Y 1 A ASP 345 ? A ASP 82  
19 1 Y 1 A THR 346 ? A THR 83  
20 1 Y 1 A THR 347 ? A THR 84  
21 1 Y 1 A PRO 348 ? A PRO 85  
22 1 Y 1 A PHE 349 ? A PHE 86  
23 1 Y 1 A GLY 350 ? A GLY 87  
24 1 Y 1 A GLN 351 ? A GLN 88  
25 1 Y 1 A GLN 352 ? A GLN 89  
26 1 Y 1 A ARG 353 ? A ARG 90  
27 1 Y 1 A VAL 354 ? A VAL 91  
28 1 Y 1 A PHE 355 ? A PHE 92  
29 1 Y 1 A LYS 356 ? A LYS 93  
30 1 Y 1 A GLU 357 ? A GLU 94  
31 1 Y 1 A PHE 413 ? A PHE 150 
32 1 Y 1 A THR 414 ? A THR 151 
33 1 Y 1 A ASP 415 ? A ASP 152 
34 1 Y 1 A GLU 416 ? A GLU 153 
35 1 Y 1 A ASN 417 ? A ASN 154 
36 1 Y 1 A LYS 418 ? A LYS 155 
37 1 Y 1 A GLY 456 ? A GLY 193 
38 1 Y 1 A LYS 457 ? A LYS 194 
39 1 Y 1 A ARG 458 ? A ARG 195 
40 1 Y 1 A GLU 459 ? A GLU 196 
41 1 Y 1 A LYS 460 ? A LYS 197 
42 1 Y 1 A LYS 461 ? A LYS 198 
43 1 Y 1 A LEU 462 ? A LEU 199 
44 1 Y 1 A GLY 463 ? A GLY 200 
45 1 Y 1 A GLU 464 ? A GLU 201 
46 1 Y 1 A PHE 465 ? A PHE 202 
47 1 Y 1 A GLY 466 ? A GLY 203 
48 1 Y 1 A LYS 467 ? A LYS 204 
49 1 Y 1 A ALA 468 ? A ALA 205 
50 1 Y 1 A LYS 469 ? A LYS 206 
51 1 Y 1 A GLY 470 ? A GLY 207 
52 1 Y 1 A SER 471 ? A SER 208 
53 1 Y 1 A ARG 472 ? A ARG 209 
54 1 Y 1 A ARG 582 ? A ARG 319 
55 1 Y 1 A PRO 583 ? A PRO 320 
56 1 Y 1 A THR 584 ? A THR 321 
57 1 Y 1 A PRO 585 ? A PRO 322 
58 1 Y 1 A ARG 586 ? A ARG 323 
59 1 Y 1 A GLY 587 ? A GLY 324 
60 1 Y 1 A THR 588 ? A THR 325 
61 1 Y 1 A VAL 589 ? A VAL 326 
62 1 Y 1 A THR 793 ? A THR 530 
63 1 Y 1 A THR 794 ? A THR 531 
64 1 Y 1 A TRP 795 ? A TRP 532 
65 1 Y 1 A SER 796 ? A SER 533 
66 1 Y 1 A ILE 797 ? A ILE 534 
67 1 Y 1 A HIS 798 ? A HIS 535 
68 1 Y 1 A GLU 892 ? A GLU 629 
69 1 Y 1 A GLU 893 ? A GLU 630 
70 1 Y 1 A GLU 894 ? A GLU 631 
71 1 Y 1 A GLU 895 ? A GLU 632 
72 1 Y 1 A ALA 896 ? A ALA 633 
73 1 Y 1 A GLY 897 ? A GLY 634 
74 1 Y 1 A VAL 898 ? A VAL 635 
75 1 Y 1 A LEU 899 ? A LEU 636 
76 1 Y 1 A TRP 900 ? A TRP 637 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CL  CL   CL N N 74  
CYS N    N  N N 75  
CYS CA   C  N R 76  
CYS C    C  N N 77  
CYS O    O  N N 78  
CYS CB   C  N N 79  
CYS SG   S  N N 80  
CYS OXT  O  N N 81  
CYS H    H  N N 82  
CYS H2   H  N N 83  
CYS HA   H  N N 84  
CYS HB2  H  N N 85  
CYS HB3  H  N N 86  
CYS HG   H  N N 87  
CYS HXT  H  N N 88  
DMS S    S  N N 89  
DMS O    O  N N 90  
DMS C1   C  N N 91  
DMS C2   C  N N 92  
DMS H11  H  N N 93  
DMS H12  H  N N 94  
DMS H13  H  N N 95  
DMS H21  H  N N 96  
DMS H22  H  N N 97  
DMS H23  H  N N 98  
GLN N    N  N N 99  
GLN CA   C  N S 100 
GLN C    C  N N 101 
GLN O    O  N N 102 
GLN CB   C  N N 103 
GLN CG   C  N N 104 
GLN CD   C  N N 105 
GLN OE1  O  N N 106 
GLN NE2  N  N N 107 
GLN OXT  O  N N 108 
GLN H    H  N N 109 
GLN H2   H  N N 110 
GLN HA   H  N N 111 
GLN HB2  H  N N 112 
GLN HB3  H  N N 113 
GLN HG2  H  N N 114 
GLN HG3  H  N N 115 
GLN HE21 H  N N 116 
GLN HE22 H  N N 117 
GLN HXT  H  N N 118 
GLU N    N  N N 119 
GLU CA   C  N S 120 
GLU C    C  N N 121 
GLU O    O  N N 122 
GLU CB   C  N N 123 
GLU CG   C  N N 124 
GLU CD   C  N N 125 
GLU OE1  O  N N 126 
GLU OE2  O  N N 127 
GLU OXT  O  N N 128 
GLU H    H  N N 129 
GLU H2   H  N N 130 
GLU HA   H  N N 131 
GLU HB2  H  N N 132 
GLU HB3  H  N N 133 
GLU HG2  H  N N 134 
GLU HG3  H  N N 135 
GLU HE2  H  N N 136 
GLU HXT  H  N N 137 
GLY N    N  N N 138 
GLY CA   C  N N 139 
GLY C    C  N N 140 
GLY O    O  N N 141 
GLY OXT  O  N N 142 
GLY H    H  N N 143 
GLY H2   H  N N 144 
GLY HA2  H  N N 145 
GLY HA3  H  N N 146 
GLY HXT  H  N N 147 
HIS N    N  N N 148 
HIS CA   C  N S 149 
HIS C    C  N N 150 
HIS O    O  N N 151 
HIS CB   C  N N 152 
HIS CG   C  Y N 153 
HIS ND1  N  Y N 154 
HIS CD2  C  Y N 155 
HIS CE1  C  Y N 156 
HIS NE2  N  Y N 157 
HIS OXT  O  N N 158 
HIS H    H  N N 159 
HIS H2   H  N N 160 
HIS HA   H  N N 161 
HIS HB2  H  N N 162 
HIS HB3  H  N N 163 
HIS HD1  H  N N 164 
HIS HD2  H  N N 165 
HIS HE1  H  N N 166 
HIS HE2  H  N N 167 
HIS HXT  H  N N 168 
HOH O    O  N N 169 
HOH H1   H  N N 170 
HOH H2   H  N N 171 
ILE N    N  N N 172 
ILE CA   C  N S 173 
ILE C    C  N N 174 
ILE O    O  N N 175 
ILE CB   C  N S 176 
ILE CG1  C  N N 177 
ILE CG2  C  N N 178 
ILE CD1  C  N N 179 
ILE OXT  O  N N 180 
ILE H    H  N N 181 
ILE H2   H  N N 182 
ILE HA   H  N N 183 
ILE HB   H  N N 184 
ILE HG12 H  N N 185 
ILE HG13 H  N N 186 
ILE HG21 H  N N 187 
ILE HG22 H  N N 188 
ILE HG23 H  N N 189 
ILE HD11 H  N N 190 
ILE HD12 H  N N 191 
ILE HD13 H  N N 192 
ILE HXT  H  N N 193 
LEU N    N  N N 194 
LEU CA   C  N S 195 
LEU C    C  N N 196 
LEU O    O  N N 197 
LEU CB   C  N N 198 
LEU CG   C  N N 199 
LEU CD1  C  N N 200 
LEU CD2  C  N N 201 
LEU OXT  O  N N 202 
LEU H    H  N N 203 
LEU H2   H  N N 204 
LEU HA   H  N N 205 
LEU HB2  H  N N 206 
LEU HB3  H  N N 207 
LEU HG   H  N N 208 
LEU HD11 H  N N 209 
LEU HD12 H  N N 210 
LEU HD13 H  N N 211 
LEU HD21 H  N N 212 
LEU HD22 H  N N 213 
LEU HD23 H  N N 214 
LEU HXT  H  N N 215 
LYS N    N  N N 216 
LYS CA   C  N S 217 
LYS C    C  N N 218 
LYS O    O  N N 219 
LYS CB   C  N N 220 
LYS CG   C  N N 221 
LYS CD   C  N N 222 
LYS CE   C  N N 223 
LYS NZ   N  N N 224 
LYS OXT  O  N N 225 
LYS H    H  N N 226 
LYS H2   H  N N 227 
LYS HA   H  N N 228 
LYS HB2  H  N N 229 
LYS HB3  H  N N 230 
LYS HG2  H  N N 231 
LYS HG3  H  N N 232 
LYS HD2  H  N N 233 
LYS HD3  H  N N 234 
LYS HE2  H  N N 235 
LYS HE3  H  N N 236 
LYS HZ1  H  N N 237 
LYS HZ2  H  N N 238 
LYS HZ3  H  N N 239 
LYS HXT  H  N N 240 
MES O1   O  N N 241 
MES C2   C  N N 242 
MES C3   C  N N 243 
MES N4   N  N N 244 
MES C5   C  N N 245 
MES C6   C  N N 246 
MES C7   C  N N 247 
MES C8   C  N N 248 
MES S    S  N N 249 
MES O1S  O  N N 250 
MES O2S  O  N N 251 
MES O3S  O  N N 252 
MES H21  H  N N 253 
MES H22  H  N N 254 
MES H31  H  N N 255 
MES H32  H  N N 256 
MES HN4  H  N N 257 
MES H51  H  N N 258 
MES H52  H  N N 259 
MES H61  H  N N 260 
MES H62  H  N N 261 
MES H71  H  N N 262 
MES H72  H  N N 263 
MES H81  H  N N 264 
MES H82  H  N N 265 
MET N    N  N N 266 
MET CA   C  N S 267 
MET C    C  N N 268 
MET O    O  N N 269 
MET CB   C  N N 270 
MET CG   C  N N 271 
MET SD   S  N N 272 
MET CE   C  N N 273 
MET OXT  O  N N 274 
MET H    H  N N 275 
MET H2   H  N N 276 
MET HA   H  N N 277 
MET HB2  H  N N 278 
MET HB3  H  N N 279 
MET HG2  H  N N 280 
MET HG3  H  N N 281 
MET HE1  H  N N 282 
MET HE2  H  N N 283 
MET HE3  H  N N 284 
MET HXT  H  N N 285 
O0J N1   N  N N 286 
O0J C4   C  Y N 287 
O0J C5   C  Y N 288 
O0J C6   C  Y N 289 
O0J C7   C  Y N 290 
O0J C8   C  Y N 291 
O0J C10  C  Y N 292 
O0J N    N  N N 293 
O0J C    C  N N 294 
O0J O    O  N N 295 
O0J C1   C  N N 296 
O0J C2   C  Y N 297 
O0J C3   C  Y N 298 
O0J C9   C  Y N 299 
O0J N2   N  Y N 300 
O0J S    S  Y N 301 
O0J H1   H  N N 302 
O0J H2   H  N N 303 
O0J H3   H  N N 304 
O0J H4   H  N N 305 
O0J H5   H  N N 306 
O0J H6   H  N N 307 
O0J H7   H  N N 308 
O0J H8   H  N N 309 
O0J H9   H  N N 310 
O0J H10  H  N N 311 
O0J H11  H  N N 312 
PEG C1   C  N N 313 
PEG O1   O  N N 314 
PEG C2   C  N N 315 
PEG O2   O  N N 316 
PEG C3   C  N N 317 
PEG C4   C  N N 318 
PEG O4   O  N N 319 
PEG H11  H  N N 320 
PEG H12  H  N N 321 
PEG HO1  H  N N 322 
PEG H21  H  N N 323 
PEG H22  H  N N 324 
PEG H31  H  N N 325 
PEG H32  H  N N 326 
PEG H41  H  N N 327 
PEG H42  H  N N 328 
PEG HO4  H  N N 329 
PHE N    N  N N 330 
PHE CA   C  N S 331 
PHE C    C  N N 332 
PHE O    O  N N 333 
PHE CB   C  N N 334 
PHE CG   C  Y N 335 
PHE CD1  C  Y N 336 
PHE CD2  C  Y N 337 
PHE CE1  C  Y N 338 
PHE CE2  C  Y N 339 
PHE CZ   C  Y N 340 
PHE OXT  O  N N 341 
PHE H    H  N N 342 
PHE H2   H  N N 343 
PHE HA   H  N N 344 
PHE HB2  H  N N 345 
PHE HB3  H  N N 346 
PHE HD1  H  N N 347 
PHE HD2  H  N N 348 
PHE HE1  H  N N 349 
PHE HE2  H  N N 350 
PHE HZ   H  N N 351 
PHE HXT  H  N N 352 
PO4 P    P  N N 353 
PO4 O1   O  N N 354 
PO4 O2   O  N N 355 
PO4 O3   O  N N 356 
PO4 O4   O  N N 357 
PRO N    N  N N 358 
PRO CA   C  N S 359 
PRO C    C  N N 360 
PRO O    O  N N 361 
PRO CB   C  N N 362 
PRO CG   C  N N 363 
PRO CD   C  N N 364 
PRO OXT  O  N N 365 
PRO H    H  N N 366 
PRO HA   H  N N 367 
PRO HB2  H  N N 368 
PRO HB3  H  N N 369 
PRO HG2  H  N N 370 
PRO HG3  H  N N 371 
PRO HD2  H  N N 372 
PRO HD3  H  N N 373 
PRO HXT  H  N N 374 
SER N    N  N N 375 
SER CA   C  N S 376 
SER C    C  N N 377 
SER O    O  N N 378 
SER CB   C  N N 379 
SER OG   O  N N 380 
SER OXT  O  N N 381 
SER H    H  N N 382 
SER H2   H  N N 383 
SER HA   H  N N 384 
SER HB2  H  N N 385 
SER HB3  H  N N 386 
SER HG   H  N N 387 
SER HXT  H  N N 388 
THR N    N  N N 389 
THR CA   C  N S 390 
THR C    C  N N 391 
THR O    O  N N 392 
THR CB   C  N R 393 
THR OG1  O  N N 394 
THR CG2  C  N N 395 
THR OXT  O  N N 396 
THR H    H  N N 397 
THR H2   H  N N 398 
THR HA   H  N N 399 
THR HB   H  N N 400 
THR HG1  H  N N 401 
THR HG21 H  N N 402 
THR HG22 H  N N 403 
THR HG23 H  N N 404 
THR HXT  H  N N 405 
TRP N    N  N N 406 
TRP CA   C  N S 407 
TRP C    C  N N 408 
TRP O    O  N N 409 
TRP CB   C  N N 410 
TRP CG   C  Y N 411 
TRP CD1  C  Y N 412 
TRP CD2  C  Y N 413 
TRP NE1  N  Y N 414 
TRP CE2  C  Y N 415 
TRP CE3  C  Y N 416 
TRP CZ2  C  Y N 417 
TRP CZ3  C  Y N 418 
TRP CH2  C  Y N 419 
TRP OXT  O  N N 420 
TRP H    H  N N 421 
TRP H2   H  N N 422 
TRP HA   H  N N 423 
TRP HB2  H  N N 424 
TRP HB3  H  N N 425 
TRP HD1  H  N N 426 
TRP HE1  H  N N 427 
TRP HE3  H  N N 428 
TRP HZ2  H  N N 429 
TRP HZ3  H  N N 430 
TRP HH2  H  N N 431 
TRP HXT  H  N N 432 
TYR N    N  N N 433 
TYR CA   C  N S 434 
TYR C    C  N N 435 
TYR O    O  N N 436 
TYR CB   C  N N 437 
TYR CG   C  Y N 438 
TYR CD1  C  Y N 439 
TYR CD2  C  Y N 440 
TYR CE1  C  Y N 441 
TYR CE2  C  Y N 442 
TYR CZ   C  Y N 443 
TYR OH   O  N N 444 
TYR OXT  O  N N 445 
TYR H    H  N N 446 
TYR H2   H  N N 447 
TYR HA   H  N N 448 
TYR HB2  H  N N 449 
TYR HB3  H  N N 450 
TYR HD1  H  N N 451 
TYR HD2  H  N N 452 
TYR HE1  H  N N 453 
TYR HE2  H  N N 454 
TYR HH   H  N N 455 
TYR HXT  H  N N 456 
VAL N    N  N N 457 
VAL CA   C  N S 458 
VAL C    C  N N 459 
VAL O    O  N N 460 
VAL CB   C  N N 461 
VAL CG1  C  N N 462 
VAL CG2  C  N N 463 
VAL OXT  O  N N 464 
VAL H    H  N N 465 
VAL H2   H  N N 466 
VAL HA   H  N N 467 
VAL HB   H  N N 468 
VAL HG11 H  N N 469 
VAL HG12 H  N N 470 
VAL HG13 H  N N 471 
VAL HG21 H  N N 472 
VAL HG22 H  N N 473 
VAL HG23 H  N N 474 
VAL HXT  H  N N 475 
ZN  ZN   ZN N N 476 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
DMS S   O    doub N N 83  
DMS S   C1   sing N N 84  
DMS S   C2   sing N N 85  
DMS C1  H11  sing N N 86  
DMS C1  H12  sing N N 87  
DMS C1  H13  sing N N 88  
DMS C2  H21  sing N N 89  
DMS C2  H22  sing N N 90  
DMS C2  H23  sing N N 91  
GLN N   CA   sing N N 92  
GLN N   H    sing N N 93  
GLN N   H2   sing N N 94  
GLN CA  C    sing N N 95  
GLN CA  CB   sing N N 96  
GLN CA  HA   sing N N 97  
GLN C   O    doub N N 98  
GLN C   OXT  sing N N 99  
GLN CB  CG   sing N N 100 
GLN CB  HB2  sing N N 101 
GLN CB  HB3  sing N N 102 
GLN CG  CD   sing N N 103 
GLN CG  HG2  sing N N 104 
GLN CG  HG3  sing N N 105 
GLN CD  OE1  doub N N 106 
GLN CD  NE2  sing N N 107 
GLN NE2 HE21 sing N N 108 
GLN NE2 HE22 sing N N 109 
GLN OXT HXT  sing N N 110 
GLU N   CA   sing N N 111 
GLU N   H    sing N N 112 
GLU N   H2   sing N N 113 
GLU CA  C    sing N N 114 
GLU CA  CB   sing N N 115 
GLU CA  HA   sing N N 116 
GLU C   O    doub N N 117 
GLU C   OXT  sing N N 118 
GLU CB  CG   sing N N 119 
GLU CB  HB2  sing N N 120 
GLU CB  HB3  sing N N 121 
GLU CG  CD   sing N N 122 
GLU CG  HG2  sing N N 123 
GLU CG  HG3  sing N N 124 
GLU CD  OE1  doub N N 125 
GLU CD  OE2  sing N N 126 
GLU OE2 HE2  sing N N 127 
GLU OXT HXT  sing N N 128 
GLY N   CA   sing N N 129 
GLY N   H    sing N N 130 
GLY N   H2   sing N N 131 
GLY CA  C    sing N N 132 
GLY CA  HA2  sing N N 133 
GLY CA  HA3  sing N N 134 
GLY C   O    doub N N 135 
GLY C   OXT  sing N N 136 
GLY OXT HXT  sing N N 137 
HIS N   CA   sing N N 138 
HIS N   H    sing N N 139 
HIS N   H2   sing N N 140 
HIS CA  C    sing N N 141 
HIS CA  CB   sing N N 142 
HIS CA  HA   sing N N 143 
HIS C   O    doub N N 144 
HIS C   OXT  sing N N 145 
HIS CB  CG   sing N N 146 
HIS CB  HB2  sing N N 147 
HIS CB  HB3  sing N N 148 
HIS CG  ND1  sing Y N 149 
HIS CG  CD2  doub Y N 150 
HIS ND1 CE1  doub Y N 151 
HIS ND1 HD1  sing N N 152 
HIS CD2 NE2  sing Y N 153 
HIS CD2 HD2  sing N N 154 
HIS CE1 NE2  sing Y N 155 
HIS CE1 HE1  sing N N 156 
HIS NE2 HE2  sing N N 157 
HIS OXT HXT  sing N N 158 
HOH O   H1   sing N N 159 
HOH O   H2   sing N N 160 
ILE N   CA   sing N N 161 
ILE N   H    sing N N 162 
ILE N   H2   sing N N 163 
ILE CA  C    sing N N 164 
ILE CA  CB   sing N N 165 
ILE CA  HA   sing N N 166 
ILE C   O    doub N N 167 
ILE C   OXT  sing N N 168 
ILE CB  CG1  sing N N 169 
ILE CB  CG2  sing N N 170 
ILE CB  HB   sing N N 171 
ILE CG1 CD1  sing N N 172 
ILE CG1 HG12 sing N N 173 
ILE CG1 HG13 sing N N 174 
ILE CG2 HG21 sing N N 175 
ILE CG2 HG22 sing N N 176 
ILE CG2 HG23 sing N N 177 
ILE CD1 HD11 sing N N 178 
ILE CD1 HD12 sing N N 179 
ILE CD1 HD13 sing N N 180 
ILE OXT HXT  sing N N 181 
LEU N   CA   sing N N 182 
LEU N   H    sing N N 183 
LEU N   H2   sing N N 184 
LEU CA  C    sing N N 185 
LEU CA  CB   sing N N 186 
LEU CA  HA   sing N N 187 
LEU C   O    doub N N 188 
LEU C   OXT  sing N N 189 
LEU CB  CG   sing N N 190 
LEU CB  HB2  sing N N 191 
LEU CB  HB3  sing N N 192 
LEU CG  CD1  sing N N 193 
LEU CG  CD2  sing N N 194 
LEU CG  HG   sing N N 195 
LEU CD1 HD11 sing N N 196 
LEU CD1 HD12 sing N N 197 
LEU CD1 HD13 sing N N 198 
LEU CD2 HD21 sing N N 199 
LEU CD2 HD22 sing N N 200 
LEU CD2 HD23 sing N N 201 
LEU OXT HXT  sing N N 202 
LYS N   CA   sing N N 203 
LYS N   H    sing N N 204 
LYS N   H2   sing N N 205 
LYS CA  C    sing N N 206 
LYS CA  CB   sing N N 207 
LYS CA  HA   sing N N 208 
LYS C   O    doub N N 209 
LYS C   OXT  sing N N 210 
LYS CB  CG   sing N N 211 
LYS CB  HB2  sing N N 212 
LYS CB  HB3  sing N N 213 
LYS CG  CD   sing N N 214 
LYS CG  HG2  sing N N 215 
LYS CG  HG3  sing N N 216 
LYS CD  CE   sing N N 217 
LYS CD  HD2  sing N N 218 
LYS CD  HD3  sing N N 219 
LYS CE  NZ   sing N N 220 
LYS CE  HE2  sing N N 221 
LYS CE  HE3  sing N N 222 
LYS NZ  HZ1  sing N N 223 
LYS NZ  HZ2  sing N N 224 
LYS NZ  HZ3  sing N N 225 
LYS OXT HXT  sing N N 226 
MES O1  C2   sing N N 227 
MES O1  C6   sing N N 228 
MES C2  C3   sing N N 229 
MES C2  H21  sing N N 230 
MES C2  H22  sing N N 231 
MES C3  N4   sing N N 232 
MES C3  H31  sing N N 233 
MES C3  H32  sing N N 234 
MES N4  C5   sing N N 235 
MES N4  C7   sing N N 236 
MES N4  HN4  sing N N 237 
MES C5  C6   sing N N 238 
MES C5  H51  sing N N 239 
MES C5  H52  sing N N 240 
MES C6  H61  sing N N 241 
MES C6  H62  sing N N 242 
MES C7  C8   sing N N 243 
MES C7  H71  sing N N 244 
MES C7  H72  sing N N 245 
MES C8  S    sing N N 246 
MES C8  H81  sing N N 247 
MES C8  H82  sing N N 248 
MES S   O1S  doub N N 249 
MES S   O2S  doub N N 250 
MES S   O3S  sing N N 251 
MET N   CA   sing N N 252 
MET N   H    sing N N 253 
MET N   H2   sing N N 254 
MET CA  C    sing N N 255 
MET CA  CB   sing N N 256 
MET CA  HA   sing N N 257 
MET C   O    doub N N 258 
MET C   OXT  sing N N 259 
MET CB  CG   sing N N 260 
MET CB  HB2  sing N N 261 
MET CB  HB3  sing N N 262 
MET CG  SD   sing N N 263 
MET CG  HG2  sing N N 264 
MET CG  HG3  sing N N 265 
MET SD  CE   sing N N 266 
MET CE  HE1  sing N N 267 
MET CE  HE2  sing N N 268 
MET CE  HE3  sing N N 269 
MET OXT HXT  sing N N 270 
O0J N1  C10  sing N N 271 
O0J C10 N2   doub Y N 272 
O0J C10 S    sing Y N 273 
O0J N2  C8   sing Y N 274 
O0J S   C9   sing Y N 275 
O0J C8  C9   doub Y N 276 
O0J C8  C5   sing N N 277 
O0J C6  C5   doub Y N 278 
O0J C6  C7   sing Y N 279 
O0J C5  C4   sing Y N 280 
O0J C7  C2   doub Y N 281 
O0J C4  C3   doub Y N 282 
O0J C2  C3   sing Y N 283 
O0J C2  N    sing N N 284 
O0J N   C1   sing N N 285 
O0J C1  C    sing N N 286 
O0J C1  O    doub N N 287 
O0J N1  H1   sing N N 288 
O0J N1  H2   sing N N 289 
O0J C4  H3   sing N N 290 
O0J C6  H4   sing N N 291 
O0J C7  H5   sing N N 292 
O0J N   H6   sing N N 293 
O0J C   H7   sing N N 294 
O0J C   H8   sing N N 295 
O0J C   H9   sing N N 296 
O0J C3  H10  sing N N 297 
O0J C9  H11  sing N N 298 
PEG C1  O1   sing N N 299 
PEG C1  C2   sing N N 300 
PEG C1  H11  sing N N 301 
PEG C1  H12  sing N N 302 
PEG O1  HO1  sing N N 303 
PEG C2  O2   sing N N 304 
PEG C2  H21  sing N N 305 
PEG C2  H22  sing N N 306 
PEG O2  C3   sing N N 307 
PEG C3  C4   sing N N 308 
PEG C3  H31  sing N N 309 
PEG C3  H32  sing N N 310 
PEG C4  O4   sing N N 311 
PEG C4  H41  sing N N 312 
PEG C4  H42  sing N N 313 
PEG O4  HO4  sing N N 314 
PHE N   CA   sing N N 315 
PHE N   H    sing N N 316 
PHE N   H2   sing N N 317 
PHE CA  C    sing N N 318 
PHE CA  CB   sing N N 319 
PHE CA  HA   sing N N 320 
PHE C   O    doub N N 321 
PHE C   OXT  sing N N 322 
PHE CB  CG   sing N N 323 
PHE CB  HB2  sing N N 324 
PHE CB  HB3  sing N N 325 
PHE CG  CD1  doub Y N 326 
PHE CG  CD2  sing Y N 327 
PHE CD1 CE1  sing Y N 328 
PHE CD1 HD1  sing N N 329 
PHE CD2 CE2  doub Y N 330 
PHE CD2 HD2  sing N N 331 
PHE CE1 CZ   doub Y N 332 
PHE CE1 HE1  sing N N 333 
PHE CE2 CZ   sing Y N 334 
PHE CE2 HE2  sing N N 335 
PHE CZ  HZ   sing N N 336 
PHE OXT HXT  sing N N 337 
PO4 P   O1   doub N N 338 
PO4 P   O2   sing N N 339 
PO4 P   O3   sing N N 340 
PO4 P   O4   sing N N 341 
PRO N   CA   sing N N 342 
PRO N   CD   sing N N 343 
PRO N   H    sing N N 344 
PRO CA  C    sing N N 345 
PRO CA  CB   sing N N 346 
PRO CA  HA   sing N N 347 
PRO C   O    doub N N 348 
PRO C   OXT  sing N N 349 
PRO CB  CG   sing N N 350 
PRO CB  HB2  sing N N 351 
PRO CB  HB3  sing N N 352 
PRO CG  CD   sing N N 353 
PRO CG  HG2  sing N N 354 
PRO CG  HG3  sing N N 355 
PRO CD  HD2  sing N N 356 
PRO CD  HD3  sing N N 357 
PRO OXT HXT  sing N N 358 
SER N   CA   sing N N 359 
SER N   H    sing N N 360 
SER N   H2   sing N N 361 
SER CA  C    sing N N 362 
SER CA  CB   sing N N 363 
SER CA  HA   sing N N 364 
SER C   O    doub N N 365 
SER C   OXT  sing N N 366 
SER CB  OG   sing N N 367 
SER CB  HB2  sing N N 368 
SER CB  HB3  sing N N 369 
SER OG  HG   sing N N 370 
SER OXT HXT  sing N N 371 
THR N   CA   sing N N 372 
THR N   H    sing N N 373 
THR N   H2   sing N N 374 
THR CA  C    sing N N 375 
THR CA  CB   sing N N 376 
THR CA  HA   sing N N 377 
THR C   O    doub N N 378 
THR C   OXT  sing N N 379 
THR CB  OG1  sing N N 380 
THR CB  CG2  sing N N 381 
THR CB  HB   sing N N 382 
THR OG1 HG1  sing N N 383 
THR CG2 HG21 sing N N 384 
THR CG2 HG22 sing N N 385 
THR CG2 HG23 sing N N 386 
THR OXT HXT  sing N N 387 
TRP N   CA   sing N N 388 
TRP N   H    sing N N 389 
TRP N   H2   sing N N 390 
TRP CA  C    sing N N 391 
TRP CA  CB   sing N N 392 
TRP CA  HA   sing N N 393 
TRP C   O    doub N N 394 
TRP C   OXT  sing N N 395 
TRP CB  CG   sing N N 396 
TRP CB  HB2  sing N N 397 
TRP CB  HB3  sing N N 398 
TRP CG  CD1  doub Y N 399 
TRP CG  CD2  sing Y N 400 
TRP CD1 NE1  sing Y N 401 
TRP CD1 HD1  sing N N 402 
TRP CD2 CE2  doub Y N 403 
TRP CD2 CE3  sing Y N 404 
TRP NE1 CE2  sing Y N 405 
TRP NE1 HE1  sing N N 406 
TRP CE2 CZ2  sing Y N 407 
TRP CE3 CZ3  doub Y N 408 
TRP CE3 HE3  sing N N 409 
TRP CZ2 CH2  doub Y N 410 
TRP CZ2 HZ2  sing N N 411 
TRP CZ3 CH2  sing Y N 412 
TRP CZ3 HZ3  sing N N 413 
TRP CH2 HH2  sing N N 414 
TRP OXT HXT  sing N N 415 
TYR N   CA   sing N N 416 
TYR N   H    sing N N 417 
TYR N   H2   sing N N 418 
TYR CA  C    sing N N 419 
TYR CA  CB   sing N N 420 
TYR CA  HA   sing N N 421 
TYR C   O    doub N N 422 
TYR C   OXT  sing N N 423 
TYR CB  CG   sing N N 424 
TYR CB  HB2  sing N N 425 
TYR CB  HB3  sing N N 426 
TYR CG  CD1  doub Y N 427 
TYR CG  CD2  sing Y N 428 
TYR CD1 CE1  sing Y N 429 
TYR CD1 HD1  sing N N 430 
TYR CD2 CE2  doub Y N 431 
TYR CD2 HD2  sing N N 432 
TYR CE1 CZ   doub Y N 433 
TYR CE1 HE1  sing N N 434 
TYR CE2 CZ   sing Y N 435 
TYR CE2 HE2  sing N N 436 
TYR CZ  OH   sing N N 437 
TYR OH  HH   sing N N 438 
TYR OXT HXT  sing N N 439 
VAL N   CA   sing N N 440 
VAL N   H    sing N N 441 
VAL N   H2   sing N N 442 
VAL CA  C    sing N N 443 
VAL CA  CB   sing N N 444 
VAL CA  HA   sing N N 445 
VAL C   O    doub N N 446 
VAL C   OXT  sing N N 447 
VAL CB  CG1  sing N N 448 
VAL CB  CG2  sing N N 449 
VAL CB  HB   sing N N 450 
VAL CG1 HG11 sing N N 451 
VAL CG1 HG12 sing N N 452 
VAL CG1 HG13 sing N N 453 
VAL CG2 HG21 sing N N 454 
VAL CG2 HG22 sing N N 455 
VAL CG2 HG23 sing N N 456 
VAL OXT HXT  sing N N 457 
# 
_pdbx_audit_support.ordinal                1 
_pdbx_audit_support.funding_organization   
'National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)' 
_pdbx_audit_support.grant_number           U19AI171292 
_pdbx_audit_support.country                'United States' 
# 
_pdbx_deposit_group.group_id            G_1002341 
_pdbx_deposit_group.group_description   
'Crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_pdbx_deposit_group.group_title         
'Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_pdbx_deposit_group.group_type          'changed state' 
# 
_atom_sites.entry_id                    7I29 
_atom_sites.fract_transf_matrix[1][1]   0.012154 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   -0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.008517 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   -0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.006715 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
# 
loop_
_atom_type.symbol 
C  
CL 
N  
O  
P  
S  
ZN 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . ASN A 1 10  ? -13.095 -6.338  -12.287 1.00 92.90  ? 273  ASN A N   1 
ATOM   2    C  CA  . ASN A 1 10  ? -13.006 -7.252  -11.122 1.00 94.19  ? 273  ASN A CA  1 
ATOM   3    C  C   . ASN A 1 10  ? -14.339 -7.263  -10.360 1.00 97.70  ? 273  ASN A C   1 
ATOM   4    O  O   . ASN A 1 10  ? -15.209 -8.061  -10.755 1.00 82.28  ? 273  ASN A O   1 
ATOM   5    C  CB  . ASN A 1 10  ? -11.774 -6.912  -10.274 1.00 91.13  ? 273  ASN A CB  1 
ATOM   6    C  CG  . ASN A 1 10  ? -11.569 -7.825  -9.084  1.00 89.23  ? 273  ASN A CG  1 
ATOM   7    O  OD1 . ASN A 1 10  ? -12.518 -8.412  -8.573  1.00 85.35  ? 273  ASN A OD1 1 
ATOM   8    N  ND2 . ASN A 1 10  ? -10.333 -7.939  -8.627  1.00 88.35  ? 273  ASN A ND2 1 
ATOM   9    N  N   . LEU A 1 11  ? -14.554 -6.351  -9.408  1.00 96.06  ? 274  LEU A N   1 
ATOM   10   C  CA  . LEU A 1 11  ? -15.734 -6.442  -8.492  1.00 83.94  ? 274  LEU A CA  1 
ATOM   11   C  C   . LEU A 1 11  ? -16.987 -5.858  -9.114  1.00 77.38  ? 274  LEU A C   1 
ATOM   12   O  O   . LEU A 1 11  ? -18.044 -6.154  -8.592  1.00 70.81  ? 274  LEU A O   1 
ATOM   13   C  CB  . LEU A 1 11  ? -15.427 -5.734  -7.167  1.00 87.96  ? 274  LEU A CB  1 
ATOM   14   C  CG  . LEU A 1 11  ? -14.542 -6.510  -6.195  1.00 94.09  ? 274  LEU A CG  1 
ATOM   15   C  CD1 . LEU A 1 11  ? -13.780 -5.561  -5.280  1.00 91.30  ? 274  LEU A CD1 1 
ATOM   16   C  CD2 . LEU A 1 11  ? -15.376 -7.486  -5.382  1.00 91.66  ? 274  LEU A CD2 1 
ATOM   17   N  N   . ASP A 1 12  ? -16.845 -5.065  -10.166 0.50 76.60  ? 275  ASP A N   1 
ATOM   18   C  CA  . ASP A 1 12  ? -18.054 -4.578  -10.870 0.50 81.89  ? 275  ASP A CA  1 
ATOM   19   C  C   . ASP A 1 12  ? -18.838 -5.794  -11.360 0.50 81.18  ? 275  ASP A C   1 
ATOM   20   O  O   . ASP A 1 12  ? -19.981 -5.606  -11.813 0.50 82.74  ? 275  ASP A O   1 
ATOM   21   C  CB  . ASP A 1 12  ? -17.665 -3.696  -12.052 0.50 84.98  ? 275  ASP A CB  1 
ATOM   22   C  CG  . ASP A 1 12  ? -16.593 -4.324  -12.928 0.50 88.27  ? 275  ASP A CG  1 
ATOM   23   O  OD1 . ASP A 1 12  ? -15.993 -5.331  -12.492 0.50 90.97  ? 275  ASP A OD1 1 
ATOM   24   O  OD2 . ASP A 1 12  ? -16.370 -3.806  -14.039 0.50 86.23  ? 275  ASP A OD2 1 
ATOM   25   N  N   . ILE A 1 13  ? -18.236 -6.987  -11.297 1.00 79.80  ? 276  ILE A N   1 
ATOM   26   C  CA  . ILE A 1 13  ? -18.901 -8.197  -11.868 1.00 66.22  ? 276  ILE A CA  1 
ATOM   27   C  C   . ILE A 1 13  ? -19.018 -9.261  -10.782 1.00 56.81  ? 276  ILE A C   1 
ATOM   28   O  O   . ILE A 1 13  ? -19.954 -10.041 -10.854 1.00 55.14  ? 276  ILE A O   1 
ATOM   29   C  CB  . ILE A 1 13  ? -18.098 -8.700  -13.080 1.00 64.95  ? 276  ILE A CB  1 
ATOM   30   C  CG1 . ILE A 1 13  ? -17.964 -7.620  -14.156 1.00 59.59  ? 276  ILE A CG1 1 
ATOM   31   C  CG2 . ILE A 1 13  ? -18.705 -9.973  -13.646 1.00 63.14  ? 276  ILE A CG2 1 
ATOM   32   C  CD1 . ILE A 1 13  ? -17.137 -8.038  -15.343 1.00 60.39  ? 276  ILE A CD1 1 
ATOM   33   N  N   . ILE A 1 14  ? -18.105 -9.297  -9.817  0.50 56.85  ? 277  ILE A N   1 
ATOM   34   C  CA  . ILE A 1 14  ? -18.183 -10.389 -8.818  0.50 58.18  ? 277  ILE A CA  1 
ATOM   35   C  C   . ILE A 1 14  ? -18.832 -9.798  -7.566  0.50 60.21  ? 277  ILE A C   1 
ATOM   36   O  O   . ILE A 1 14  ? -19.358 -10.576 -6.757  0.50 60.13  ? 277  ILE A O   1 
ATOM   37   C  CB  . ILE A 1 14  ? -16.775 -10.957 -8.563  0.50 58.06  ? 277  ILE A CB  1 
ATOM   38   C  CG1 . ILE A 1 14  ? -15.869 -9.937  -7.872  0.50 55.96  ? 277  ILE A CG1 1 
ATOM   39   C  CG2 . ILE A 1 14  ? -16.166 -11.454 -9.865  0.50 56.77  ? 277  ILE A CG2 1 
ATOM   40   C  CD1 . ILE A 1 14  ? -14.454 -10.413 -7.692  0.50 56.01  ? 277  ILE A CD1 1 
ATOM   41   N  N   . GLY A 1 15  ? -18.880 -8.467  -7.477  0.50 64.68  ? 278  GLY A N   1 
ATOM   42   C  CA  . GLY A 1 15  ? -19.425 -7.785  -6.285  0.50 63.41  ? 278  GLY A CA  1 
ATOM   43   C  C   . GLY A 1 15  ? -20.875 -8.113  -5.990  0.50 65.30  ? 278  GLY A C   1 
ATOM   44   O  O   . GLY A 1 15  ? -21.160 -8.502  -4.847  0.50 68.07  ? 278  GLY A O   1 
ATOM   45   N  N   . LYS A 1 16  ? -21.762 -7.964  -6.977  0.50 64.69  ? 279  LYS A N   1 
ATOM   46   C  CA  . LYS A 1 16  ? -23.206 -8.177  -6.714  0.50 61.85  ? 279  LYS A CA  1 
ATOM   47   C  C   . LYS A 1 16  ? -23.373 -9.555  -6.072  0.50 60.31  ? 279  LYS A C   1 
ATOM   48   O  O   . LYS A 1 16  ? -23.984 -9.636  -4.995  0.50 57.13  ? 279  LYS A O   1 
ATOM   49   C  CB  . LYS A 1 16  ? -24.003 -8.039  -8.017  0.50 63.83  ? 279  LYS A CB  1 
ATOM   50   C  CG  . LYS A 1 16  ? -25.514 -8.009  -7.840  0.50 63.63  ? 279  LYS A CG  1 
ATOM   51   C  CD  . LYS A 1 16  ? -26.271 -7.975  -9.146  0.50 62.49  ? 279  LYS A CD  1 
ATOM   52   C  CE  . LYS A 1 16  ? -27.726 -7.594  -8.974  0.50 61.53  ? 279  LYS A CE  1 
ATOM   53   N  NZ  . LYS A 1 16  ? -28.344 -8.307  -7.832  0.50 61.67  ? 279  LYS A NZ  1 
ATOM   54   N  N   . ARG A 1 17  ? -22.783 -10.583 -6.683  0.50 60.25  ? 280  ARG A N   1 
ATOM   55   C  CA  . ARG A 1 17  ? -22.885 -11.965 -6.147  0.50 62.86  ? 280  ARG A CA  1 
ATOM   56   C  C   . ARG A 1 17  ? -22.299 -12.010 -4.737  0.50 62.67  ? 280  ARG A C   1 
ATOM   57   O  O   . ARG A 1 17  ? -22.942 -12.589 -3.845  0.50 58.86  ? 280  ARG A O   1 
ATOM   58   C  CB  . ARG A 1 17  ? -22.132 -12.937 -7.060  0.50 63.33  ? 280  ARG A CB  1 
ATOM   59   C  CG  . ARG A 1 17  ? -22.904 -13.342 -8.307  0.50 64.12  ? 280  ARG A CG  1 
ATOM   60   C  CD  . ARG A 1 17  ? -22.055 -14.084 -9.319  0.50 62.33  ? 280  ARG A CD  1 
ATOM   61   N  NE  . ARG A 1 17  ? -21.421 -13.181 -10.264 0.50 62.42  ? 280  ARG A NE  1 
ATOM   62   C  CZ  . ARG A 1 17  ? -20.557 -13.563 -11.194 0.50 61.55  ? 280  ARG A CZ  1 
ATOM   63   N  NH1 . ARG A 1 17  ? -20.212 -14.836 -11.289 0.50 60.70  ? 280  ARG A NH1 1 
ATOM   64   N  NH2 . ARG A 1 17  ? -20.036 -12.674 -12.020 0.50 60.18  ? 280  ARG A NH2 1 
ATOM   65   N  N   . ILE A 1 18  ? -21.113 -11.432 -4.559  0.50 67.22  ? 281  ILE A N   1 
ATOM   66   C  CA  . ILE A 1 18  ? -20.444 -11.463 -3.229  0.50 71.75  ? 281  ILE A CA  1 
ATOM   67   C  C   . ILE A 1 18  ? -21.342 -10.714 -2.241  0.50 73.61  ? 281  ILE A C   1 
ATOM   68   O  O   . ILE A 1 18  ? -21.665 -11.292 -1.180  0.50 73.42  ? 281  ILE A O   1 
ATOM   69   C  CB  . ILE A 1 18  ? -19.028 -10.863 -3.298  0.50 74.84  ? 281  ILE A CB  1 
ATOM   70   C  CG1 . ILE A 1 18  ? -18.141 -11.638 -4.276  0.50 75.48  ? 281  ILE A CG1 1 
ATOM   71   C  CG2 . ILE A 1 18  ? -18.404 -10.784 -1.914  0.50 76.29  ? 281  ILE A CG2 1 
ATOM   72   C  CD1 . ILE A 1 18  ? -16.847 -10.941 -4.621  0.50 74.47  ? 281  ILE A CD1 1 
ATOM   73   N  N   . GLU A 1 19  ? -21.745 -9.486  -2.575  0.50 72.69  ? 282  GLU A N   1 
ATOM   74   C  CA  . GLU A 1 19  ? -22.552 -8.700  -1.605  0.50 76.28  ? 282  GLU A CA  1 
ATOM   75   C  C   . GLU A 1 19  ? -23.738 -9.561  -1.179  0.50 76.14  ? 282  GLU A C   1 
ATOM   76   O  O   . GLU A 1 19  ? -23.938 -9.718  0.035   0.50 75.21  ? 282  GLU A O   1 
ATOM   77   C  CB  . GLU A 1 19  ? -23.022 -7.371  -2.189  0.50 75.77  ? 282  GLU A CB  1 
ATOM   78   C  CG  . GLU A 1 19  ? -21.885 -6.442  -2.572  0.50 75.57  ? 282  GLU A CG  1 
ATOM   79   C  CD  . GLU A 1 19  ? -22.337 -5.125  -3.181  0.50 76.40  ? 282  GLU A CD  1 
ATOM   80   O  OE1 . GLU A 1 19  ? -23.559 -4.941  -3.344  0.50 75.54  ? 282  GLU A OE1 1 
ATOM   81   O  OE2 . GLU A 1 19  ? -21.467 -4.287  -3.486  0.50 77.81  ? 282  GLU A OE2 1 
ATOM   82   N  N   . LYS A 1 20  ? -24.438 -10.151 -2.149  0.50 77.44  ? 283  LYS A N   1 
ATOM   83   C  CA  . LYS A 1 20  ? -25.655 -10.935 -1.826  0.50 79.24  ? 283  LYS A CA  1 
ATOM   84   C  C   . LYS A 1 20  ? -25.311 -12.025 -0.810  0.50 80.05  ? 283  LYS A C   1 
ATOM   85   O  O   . LYS A 1 20  ? -26.053 -12.145 0.176   0.50 82.66  ? 283  LYS A O   1 
ATOM   86   C  CB  . LYS A 1 20  ? -26.233 -11.548 -3.106  0.50 81.15  ? 283  LYS A CB  1 
ATOM   87   C  CG  . LYS A 1 20  ? -27.466 -12.422 -2.923  0.50 81.49  ? 283  LYS A CG  1 
ATOM   88   C  CD  . LYS A 1 20  ? -27.966 -13.014 -4.224  0.50 83.94  ? 283  LYS A CD  1 
ATOM   89   C  CE  . LYS A 1 20  ? -29.318 -13.685 -4.107  0.50 83.17  ? 283  LYS A CE  1 
ATOM   90   N  NZ  . LYS A 1 20  ? -29.261 -14.897 -3.257  0.50 82.47  ? 283  LYS A NZ  1 
ATOM   91   N  N   . ILE A 1 21  ? -24.224 -12.762 -1.028  0.50 81.99  ? 284  ILE A N   1 
ATOM   92   C  CA  . ILE A 1 21  ? -23.868 -13.910 -0.144  0.50 84.07  ? 284  ILE A CA  1 
ATOM   93   C  C   . ILE A 1 21  ? -23.508 -13.362 1.242   0.50 82.36  ? 284  ILE A C   1 
ATOM   94   O  O   . ILE A 1 21  ? -23.886 -13.993 2.242   0.50 76.60  ? 284  ILE A O   1 
ATOM   95   C  CB  . ILE A 1 21  ? -22.726 -14.738 -0.770  0.50 86.44  ? 284  ILE A CB  1 
ATOM   96   C  CG1 . ILE A 1 21  ? -23.120 -15.301 -2.137  0.50 88.08  ? 284  ILE A CG1 1 
ATOM   97   C  CG2 . ILE A 1 21  ? -22.271 -15.831 0.185   0.50 86.86  ? 284  ILE A CG2 1 
ATOM   98   C  CD1 . ILE A 1 21  ? -21.989 -15.992 -2.863  0.50 88.67  ? 284  ILE A CD1 1 
ATOM   99   N  N   . LYS A 1 22  ? -22.806 -12.226 1.286   0.50 83.33  ? 285  LYS A N   1 
ATOM   100  C  CA  . LYS A 1 22  ? -22.395 -11.641 2.589   0.50 87.01  ? 285  LYS A CA  1 
ATOM   101  C  C   . LYS A 1 22  ? -23.646 -11.237 3.375   0.50 86.40  ? 285  LYS A C   1 
ATOM   102  O  O   . LYS A 1 22  ? -23.806 -11.720 4.508   0.50 81.17  ? 285  LYS A O   1 
ATOM   103  C  CB  . LYS A 1 22  ? -21.469 -10.438 2.405   0.50 89.56  ? 285  LYS A CB  1 
ATOM   104  C  CG  . LYS A 1 22  ? -21.228 -9.606  3.658   0.50 90.89  ? 285  LYS A CG  1 
ATOM   105  C  CD  . LYS A 1 22  ? -20.467 -8.327  3.384   0.50 90.63  ? 285  LYS A CD  1 
ATOM   106  C  CE  . LYS A 1 22  ? -20.846 -7.205  4.328   0.50 92.18  ? 285  LYS A CE  1 
ATOM   107  N  NZ  . LYS A 1 22  ? -20.122 -5.949  4.021   0.50 91.73  ? 285  LYS A NZ  1 
ATOM   108  N  N   . GLN A 1 23  ? -24.528 -10.439 2.765   0.50 87.18  ? 286  GLN A N   1 
ATOM   109  C  CA  . GLN A 1 23  ? -25.776 -9.991  3.442   0.50 89.09  ? 286  GLN A CA  1 
ATOM   110  C  C   . GLN A 1 23  ? -26.474 -11.195 4.079   0.50 89.93  ? 286  GLN A C   1 
ATOM   111  O  O   . GLN A 1 23  ? -26.804 -11.106 5.270   0.50 93.42  ? 286  GLN A O   1 
ATOM   112  C  CB  . GLN A 1 23  ? -26.712 -9.308  2.445   0.50 87.68  ? 286  GLN A CB  1 
ATOM   113  C  CG  . GLN A 1 23  ? -26.095 -8.084  1.785   0.50 88.95  ? 286  GLN A CG  1 
ATOM   114  C  CD  . GLN A 1 23  ? -26.846 -7.638  0.554   0.50 90.37  ? 286  GLN A CD  1 
ATOM   115  O  OE1 . GLN A 1 23  ? -27.868 -8.211  0.182   0.50 93.53  ? 286  GLN A OE1 1 
ATOM   116  N  NE2 . GLN A 1 23  ? -26.337 -6.603  -0.093  0.50 88.95  ? 286  GLN A NE2 1 
ATOM   117  N  N   . GLU A 1 24  ? -26.677 -12.278 3.323   0.50 88.59  ? 287  GLU A N   1 
ATOM   118  C  CA  . GLU A 1 24  ? -27.424 -13.447 3.858   0.50 88.54  ? 287  GLU A CA  1 
ATOM   119  C  C   . GLU A 1 24  ? -26.606 -14.094 4.976   0.50 92.53  ? 287  GLU A C   1 
ATOM   120  O  O   . GLU A 1 24  ? -27.154 -14.955 5.691   0.50 96.24  ? 287  GLU A O   1 
ATOM   121  C  CB  . GLU A 1 24  ? -27.711 -14.482 2.769   0.50 87.59  ? 287  GLU A CB  1 
ATOM   122  C  CG  . GLU A 1 24  ? -28.056 -13.883 1.419   0.50 87.31  ? 287  GLU A CG  1 
ATOM   123  C  CD  . GLU A 1 24  ? -27.905 -14.840 0.248   0.50 86.94  ? 287  GLU A CD  1 
ATOM   124  O  OE1 . GLU A 1 24  ? -28.344 -14.486 -0.860  0.50 85.27  ? 287  GLU A OE1 1 
ATOM   125  O  OE2 . GLU A 1 24  ? -27.343 -15.934 0.445   0.50 85.05  ? 287  GLU A OE2 1 
ATOM   126  N  N   . HIS A 1 25  ? -25.336 -13.707 5.103   0.50 95.46  ? 288  HIS A N   1 
ATOM   127  C  CA  . HIS A 1 25  ? -24.459 -14.289 6.154   0.50 97.99  ? 288  HIS A CA  1 
ATOM   128  C  C   . HIS A 1 25  ? -23.753 -13.171 6.928   0.50 101.68 ? 288  HIS A C   1 
ATOM   129  O  O   . HIS A 1 25  ? -22.517 -13.222 7.017   0.50 103.23 ? 288  HIS A O   1 
ATOM   130  C  CB  . HIS A 1 25  ? -23.452 -15.240 5.499   0.50 94.99  ? 288  HIS A CB  1 
ATOM   131  C  CG  . HIS A 1 25  ? -24.064 -16.485 4.958   0.50 94.14  ? 288  HIS A CG  1 
ATOM   132  N  ND1 . HIS A 1 25  ? -24.567 -17.476 5.777   0.50 95.17  ? 288  HIS A ND1 1 
ATOM   133  C  CD2 . HIS A 1 25  ? -24.249 -16.909 3.690   0.50 92.50  ? 288  HIS A CD2 1 
ATOM   134  C  CE1 . HIS A 1 25  ? -25.042 -18.455 5.035   0.50 94.16  ? 288  HIS A CE1 1 
ATOM   135  N  NE2 . HIS A 1 25  ? -24.857 -18.131 3.751   0.50 91.89  ? 288  HIS A NE2 1 
ATOM   136  N  N   . GLU A 1 26  ? -24.500 -12.226 7.506   0.50 105.78 ? 289  GLU A N   1 
ATOM   137  C  CA  . GLU A 1 26  ? -23.851 -11.036 8.140   0.50 110.64 ? 289  GLU A CA  1 
ATOM   138  C  C   . GLU A 1 26  ? -23.212 -11.362 9.493   0.50 111.70 ? 289  GLU A C   1 
ATOM   139  O  O   . GLU A 1 26  ? -22.182 -10.739 9.818   0.50 108.65 ? 289  GLU A O   1 
ATOM   140  C  CB  . GLU A 1 26  ? -24.878 -9.914  8.300   0.50 110.59 ? 289  GLU A CB  1 
ATOM   141  C  CG  . GLU A 1 26  ? -24.252 -8.535  8.394   0.50 110.02 ? 289  GLU A CG  1 
ATOM   142  C  CD  . GLU A 1 26  ? -23.856 -7.937  7.055   0.50 111.25 ? 289  GLU A CD  1 
ATOM   143  O  OE1 . GLU A 1 26  ? -22.967 -7.064  7.036   0.50 110.61 ? 289  GLU A OE1 1 
ATOM   144  O  OE2 . GLU A 1 26  ? -24.451 -8.338  6.037   0.50 109.84 ? 289  GLU A OE2 1 
ATOM   145  N  N   . THR A 1 27  ? -23.784 -12.292 10.247  0.50 114.14 ? 290  THR A N   1 
ATOM   146  C  CA  . THR A 1 27  ? -23.295 -12.613 11.618  0.50 117.62 ? 290  THR A CA  1 
ATOM   147  C  C   . THR A 1 27  ? -21.835 -13.089 11.562  0.50 119.53 ? 290  THR A C   1 
ATOM   148  O  O   . THR A 1 27  ? -21.010 -12.512 12.299  0.50 124.87 ? 290  THR A O   1 
ATOM   149  C  CB  . THR A 1 27  ? -24.211 -13.631 12.313  0.50 118.86 ? 290  THR A CB  1 
ATOM   150  O  OG1 . THR A 1 27  ? -24.292 -14.801 11.499  0.50 124.18 ? 290  THR A OG1 1 
ATOM   151  C  CG2 . THR A 1 27  ? -25.607 -13.099 12.558  0.50 118.83 ? 290  THR A CG2 1 
ATOM   152  N  N   . SER A 1 28  ? -21.524 -14.085 10.722  0.50 116.24 ? 291  SER A N   1 
ATOM   153  C  CA  . SER A 1 28  ? -20.221 -14.806 10.706  0.50 110.76 ? 291  SER A CA  1 
ATOM   154  C  C   . SER A 1 28  ? -19.364 -14.395 9.503   0.50 105.58 ? 291  SER A C   1 
ATOM   155  O  O   . SER A 1 28  ? -18.646 -15.269 8.986   0.50 105.90 ? 291  SER A O   1 
ATOM   156  C  CB  . SER A 1 28  ? -20.428 -16.300 10.709  0.50 112.11 ? 291  SER A CB  1 
ATOM   157  O  OG  . SER A 1 28  ? -21.226 -16.703 9.605   0.50 114.08 ? 291  SER A OG  1 
ATOM   158  N  N   . TRP A 1 29  ? -19.412 -13.127 9.085   0.50 101.41 ? 292  TRP A N   1 
ATOM   159  C  CA  . TRP A 1 29  ? -18.619 -12.626 7.929   0.50 101.57 ? 292  TRP A CA  1 
ATOM   160  C  C   . TRP A 1 29  ? -17.184 -12.330 8.377   0.50 97.91  ? 292  TRP A C   1 
ATOM   161  O  O   . TRP A 1 29  ? -16.677 -11.233 8.061   0.50 92.95  ? 292  TRP A O   1 
ATOM   162  C  CB  . TRP A 1 29  ? -19.271 -11.399 7.282   0.50 101.69 ? 292  TRP A CB  1 
ATOM   163  C  CG  . TRP A 1 29  ? -18.710 -11.097 5.926   0.50 103.40 ? 292  TRP A CG  1 
ATOM   164  C  CD1 . TRP A 1 29  ? -18.073 -9.958  5.525   0.50 103.19 ? 292  TRP A CD1 1 
ATOM   165  C  CD2 . TRP A 1 29  ? -18.706 -11.978 4.788   0.50 100.25 ? 292  TRP A CD2 1 
ATOM   166  N  NE1 . TRP A 1 29  ? -17.689 -10.062 4.215   0.50 101.43 ? 292  TRP A NE1 1 
ATOM   167  C  CE2 . TRP A 1 29  ? -18.063 -11.291 3.736   0.50 101.66 ? 292  TRP A CE2 1 
ATOM   168  C  CE3 . TRP A 1 29  ? -19.188 -13.271 4.555   0.50 97.99  ? 292  TRP A CE3 1 
ATOM   169  C  CZ2 . TRP A 1 29  ? -17.895 -11.856 2.474   0.50 101.16 ? 292  TRP A CZ2 1 
ATOM   170  C  CZ3 . TRP A 1 29  ? -19.020 -13.828 3.308   0.50 98.59  ? 292  TRP A CZ3 1 
ATOM   171  C  CH2 . TRP A 1 29  ? -18.383 -13.128 2.283   0.50 100.01 ? 292  TRP A CH2 1 
ATOM   172  N  N   . HIS A 1 30  ? -16.555 -13.285 9.069   0.50 96.82  ? 293  HIS A N   1 
ATOM   173  C  CA  . HIS A 1 30  ? -15.175 -13.167 9.611   0.50 97.71  ? 293  HIS A CA  1 
ATOM   174  C  C   . HIS A 1 30  ? -14.160 -13.283 8.469   0.50 97.78  ? 293  HIS A C   1 
ATOM   175  O  O   . HIS A 1 30  ? -14.088 -14.360 7.852   0.50 99.03  ? 293  HIS A O   1 
ATOM   176  C  CB  . HIS A 1 30  ? -14.939 -14.198 10.724  0.50 96.29  ? 293  HIS A CB  1 
ATOM   177  C  CG  . HIS A 1 30  ? -15.114 -15.619 10.304  0.50 94.65  ? 293  HIS A CG  1 
ATOM   178  N  ND1 . HIS A 1 30  ? -16.360 -16.180 10.099  0.50 93.62  ? 293  HIS A ND1 1 
ATOM   179  C  CD2 . HIS A 1 30  ? -14.213 -16.601 10.082  0.50 94.78  ? 293  HIS A CD2 1 
ATOM   180  C  CE1 . HIS A 1 30  ? -16.217 -17.444 9.755   0.50 95.41  ? 293  HIS A CE1 1 
ATOM   181  N  NE2 . HIS A 1 30  ? -14.908 -17.727 9.738   0.50 95.07  ? 293  HIS A NE2 1 
ATOM   182  N  N   . TYR A 1 31  ? -13.424 -12.197 8.208   0.50 100.96 ? 294  TYR A N   1 
ATOM   183  C  CA  . TYR A 1 31  ? -12.333 -12.099 7.203   0.50 102.76 ? 294  TYR A CA  1 
ATOM   184  C  C   . TYR A 1 31  ? -11.076 -12.777 7.764   0.50 103.63 ? 294  TYR A C   1 
ATOM   185  O  O   . TYR A 1 31  ? -10.113 -12.067 8.109   0.50 104.59 ? 294  TYR A O   1 
ATOM   186  C  CB  . TYR A 1 31  ? -12.086 -10.629 6.847   0.50 104.42 ? 294  TYR A CB  1 
ATOM   187  C  CG  . TYR A 1 31  ? -11.097 -10.392 5.733   0.50 110.25 ? 294  TYR A CG  1 
ATOM   188  C  CD1 . TYR A 1 31  ? -11.338 -10.856 4.450   0.50 112.49 ? 294  TYR A CD1 1 
ATOM   189  C  CD2 . TYR A 1 31  ? -9.927  -9.681  5.952   0.50 111.34 ? 294  TYR A CD2 1 
ATOM   190  C  CE1 . TYR A 1 31  ? -10.439 -10.636 3.419   0.50 112.12 ? 294  TYR A CE1 1 
ATOM   191  C  CE2 . TYR A 1 31  ? -9.017  -9.451  4.933   0.50 109.16 ? 294  TYR A CE2 1 
ATOM   192  C  CZ  . TYR A 1 31  ? -9.274  -9.930  3.661   0.50 109.91 ? 294  TYR A CZ  1 
ATOM   193  O  OH  . TYR A 1 31  ? -8.386  -9.712  2.648   0.50 107.81 ? 294  TYR A OH  1 
ATOM   194  N  N   . ASP A 1 32  ? -11.098 -14.113 7.845   0.50 106.77 ? 295  ASP A N   1 
ATOM   195  C  CA  . ASP A 1 32  ? -10.035 -14.958 8.459   0.50 110.88 ? 295  ASP A CA  1 
ATOM   196  C  C   . ASP A 1 32  ? -8.707  -14.743 7.721   0.50 112.27 ? 295  ASP A C   1 
ATOM   197  O  O   . ASP A 1 32  ? -8.661  -14.984 6.498   0.50 114.58 ? 295  ASP A O   1 
ATOM   198  C  CB  . ASP A 1 32  ? -10.432 -16.438 8.448   0.50 109.53 ? 295  ASP A CB  1 
ATOM   199  C  CG  . ASP A 1 32  ? -9.711  -17.275 9.491   0.50 111.52 ? 295  ASP A CG  1 
ATOM   200  O  OD1 . ASP A 1 32  ? -9.563  -16.790 10.632  0.50 111.48 ? 295  ASP A OD1 1 
ATOM   201  O  OD2 . ASP A 1 32  ? -9.304  -18.406 9.155   0.50 110.43 ? 295  ASP A OD2 1 
ATOM   202  N  N   . GLN A 1 33  ? -7.669  -14.319 8.450   0.50 112.95 ? 296  GLN A N   1 
ATOM   203  C  CA  . GLN A 1 33  ? -6.301  -14.070 7.918   0.50 113.95 ? 296  GLN A CA  1 
ATOM   204  C  C   . GLN A 1 33  ? -5.540  -15.401 7.861   0.50 111.93 ? 296  GLN A C   1 
ATOM   205  O  O   . GLN A 1 33  ? -4.323  -15.376 7.581   0.50 113.05 ? 296  GLN A O   1 
ATOM   206  C  CB  . GLN A 1 33  ? -5.569  -13.051 8.795   0.50 116.86 ? 296  GLN A CB  1 
ATOM   207  C  CG  . GLN A 1 33  ? -6.342  -11.755 9.009   0.50 117.44 ? 296  GLN A CG  1 
ATOM   208  C  CD  . GLN A 1 33  ? -6.165  -10.779 7.871   0.50 119.22 ? 296  GLN A CD  1 
ATOM   209  O  OE1 . GLN A 1 33  ? -5.065  -10.579 7.362   0.50 119.60 ? 296  GLN A OE1 1 
ATOM   210  N  NE2 . GLN A 1 33  ? -7.257  -10.150 7.467   0.50 120.83 ? 296  GLN A NE2 1 
ATOM   211  N  N   . ASP A 1 34  ? -6.241  -16.513 8.116   0.50 107.41 ? 297  ASP A N   1 
ATOM   212  C  CA  . ASP A 1 34  ? -5.677  -17.890 8.133   0.50 104.38 ? 297  ASP A CA  1 
ATOM   213  C  C   . ASP A 1 34  ? -6.013  -18.601 6.815   0.50 105.82 ? 297  ASP A C   1 
ATOM   214  O  O   . ASP A 1 34  ? -5.644  -19.786 6.678   0.50 104.53 ? 297  ASP A O   1 
ATOM   215  C  CB  . ASP A 1 34  ? -6.208  -18.695 9.323   0.50 100.70 ? 297  ASP A CB  1 
ATOM   216  C  CG  . ASP A 1 34  ? -6.100  -17.979 10.659  0.50 98.44  ? 297  ASP A CG  1 
ATOM   217  O  OD1 . ASP A 1 34  ? -5.061  -17.330 10.899  0.50 97.57  ? 297  ASP A OD1 1 
ATOM   218  O  OD2 . ASP A 1 34  ? -7.059  -18.076 11.449  0.50 90.98  ? 297  ASP A OD2 1 
ATOM   219  N  N   . HIS A 1 35  ? -6.685  -17.905 5.889   0.50 106.16 ? 298  HIS A N   1 
ATOM   220  C  CA  . HIS A 1 35  ? -7.148  -18.439 4.577   0.50 102.73 ? 298  HIS A CA  1 
ATOM   221  C  C   . HIS A 1 35  ? -5.955  -18.965 3.780   0.50 101.37 ? 298  HIS A C   1 
ATOM   222  O  O   . HIS A 1 35  ? -4.961  -18.262 3.605   0.50 104.40 ? 298  HIS A O   1 
ATOM   223  C  CB  . HIS A 1 35  ? -7.952  -17.375 3.811   0.50 102.30 ? 298  HIS A CB  1 
ATOM   224  C  CG  . HIS A 1 35  ? -7.167  -16.179 3.381   0.50 102.99 ? 298  HIS A CG  1 
ATOM   225  N  ND1 . HIS A 1 35  ? -7.189  -14.985 4.082   0.50 104.47 ? 298  HIS A ND1 1 
ATOM   226  C  CD2 . HIS A 1 35  ? -6.364  -15.972 2.313   0.50 100.49 ? 298  HIS A CD2 1 
ATOM   227  C  CE1 . HIS A 1 35  ? -6.424  -14.102 3.471   0.50 102.45 ? 298  HIS A CE1 1 
ATOM   228  N  NE2 . HIS A 1 35  ? -5.906  -14.683 2.383   0.50 102.13 ? 298  HIS A NE2 1 
ATOM   229  N  N   . PRO A 1 36  ? -6.015  -20.223 3.283   0.50 95.59  ? 299  PRO A N   1 
ATOM   230  C  CA  . PRO A 1 36  ? -4.901  -20.820 2.546   0.50 93.65  ? 299  PRO A CA  1 
ATOM   231  C  C   . PRO A 1 36  ? -4.899  -20.548 1.033   0.50 92.53  ? 299  PRO A C   1 
ATOM   232  O  O   . PRO A 1 36  ? -4.775  -21.497 0.283   0.50 97.41  ? 299  PRO A O   1 
ATOM   233  C  CB  . PRO A 1 36  ? -5.129  -22.318 2.802   0.50 92.88  ? 299  PRO A CB  1 
ATOM   234  C  CG  . PRO A 1 36  ? -6.638  -22.463 2.871   0.50 91.18  ? 299  PRO A CG  1 
ATOM   235  C  CD  . PRO A 1 36  ? -7.144  -21.153 3.442   0.50 92.78  ? 299  PRO A CD  1 
ATOM   236  N  N   . TYR A 1 37  ? -5.004  -19.279 0.621   0.50 89.28  ? 300  TYR A N   1 
ATOM   237  C  CA  . TYR A 1 37  ? -5.142  -18.872 -0.804  0.50 87.02  ? 300  TYR A CA  1 
ATOM   238  C  C   . TYR A 1 37  ? -3.963  -17.986 -1.215  0.50 84.61  ? 300  TYR A C   1 
ATOM   239  O  O   . TYR A 1 37  ? -3.535  -17.130 -0.419  0.50 83.13  ? 300  TYR A O   1 
ATOM   240  C  CB  . TYR A 1 37  ? -6.492  -18.183 -1.035  0.50 85.95  ? 300  TYR A CB  1 
ATOM   241  C  CG  . TYR A 1 37  ? -7.672  -19.003 -0.579  0.50 82.16  ? 300  TYR A CG  1 
ATOM   242  C  CD1 . TYR A 1 37  ? -8.141  -20.063 -1.335  0.50 82.21  ? 300  TYR A CD1 1 
ATOM   243  C  CD2 . TYR A 1 37  ? -8.297  -18.746 0.630   0.50 80.83  ? 300  TYR A CD2 1 
ATOM   244  C  CE1 . TYR A 1 37  ? -9.208  -20.839 -0.912  0.50 79.50  ? 300  TYR A CE1 1 
ATOM   245  C  CE2 . TYR A 1 37  ? -9.365  -19.511 1.068   0.50 79.34  ? 300  TYR A CE2 1 
ATOM   246  C  CZ  . TYR A 1 37  ? -9.823  -20.561 0.294   0.50 76.30  ? 300  TYR A CZ  1 
ATOM   247  O  OH  . TYR A 1 37  ? -10.875 -21.316 0.722   0.50 77.72  ? 300  TYR A OH  1 
ATOM   248  N  N   . LYS A 1 38  ? -3.461  -18.211 -2.433  0.50 86.94  ? 301  LYS A N   1 
ATOM   249  C  CA  . LYS A 1 38  ? -2.407  -17.397 -3.094  0.50 87.34  ? 301  LYS A CA  1 
ATOM   250  C  C   . LYS A 1 38  ? -2.951  -16.888 -4.434  0.50 85.03  ? 301  LYS A C   1 
ATOM   251  O  O   . LYS A 1 38  ? -3.049  -15.657 -4.600  0.50 84.52  ? 301  LYS A O   1 
ATOM   252  C  CB  . LYS A 1 38  ? -1.132  -18.224 -3.293  0.50 90.06  ? 301  LYS A CB  1 
ATOM   253  C  CG  . LYS A 1 38  ? 0.111   -17.416 -3.644  0.50 93.55  ? 301  LYS A CG  1 
ATOM   254  C  CD  . LYS A 1 38  ? 0.325   -16.217 -2.741  0.50 96.02  ? 301  LYS A CD  1 
ATOM   255  C  CE  . LYS A 1 38  ? 1.586   -15.443 -3.063  0.50 100.54 ? 301  LYS A CE  1 
ATOM   256  N  NZ  . LYS A 1 38  ? 2.804   -16.169 -2.630  0.50 102.19 ? 301  LYS A NZ  1 
ATOM   257  N  N   . THR A 1 39  ? -3.307  -17.811 -5.336  0.50 82.13  ? 302  THR A N   1 
ATOM   258  C  CA  . THR A 1 39  ? -3.828  -17.528 -6.703  0.50 79.00  ? 302  THR A CA  1 
ATOM   259  C  C   . THR A 1 39  ? -5.328  -17.217 -6.634  0.50 72.82  ? 302  THR A C   1 
ATOM   260  O  O   . THR A 1 39  ? -5.751  -16.234 -7.269  0.50 71.52  ? 302  THR A O   1 
ATOM   261  C  CB  . THR A 1 39  ? -3.567  -18.708 -7.646  0.50 79.81  ? 302  THR A CB  1 
ATOM   262  O  OG1 . THR A 1 39  ? -4.456  -19.756 -7.260  0.50 79.38  ? 302  THR A OG1 1 
ATOM   263  C  CG2 . THR A 1 39  ? -2.132  -19.187 -7.607  0.50 80.75  ? 302  THR A CG2 1 
ATOM   264  N  N   . TRP A 1 40  ? -6.092  -18.034 -5.901  0.50 66.45  ? 303  TRP A N   1 
ATOM   265  C  CA  . TRP A 1 40  ? -7.546  -17.840 -5.657  0.50 64.50  ? 303  TRP A CA  1 
ATOM   266  C  C   . TRP A 1 40  ? -7.762  -16.595 -4.790  0.50 65.78  ? 303  TRP A C   1 
ATOM   267  O  O   . TRP A 1 40  ? -7.428  -16.647 -3.588  0.50 60.05  ? 303  TRP A O   1 
ATOM   268  C  CB  . TRP A 1 40  ? -8.160  -19.086 -5.009  0.50 62.44  ? 303  TRP A CB  1 
ATOM   269  C  CG  . TRP A 1 40  ? -8.629  -20.100 -6.004  0.50 62.65  ? 303  TRP A CG  1 
ATOM   270  C  CD1 . TRP A 1 40  ? -8.156  -21.368 -6.176  0.50 62.76  ? 303  TRP A CD1 1 
ATOM   271  C  CD2 . TRP A 1 40  ? -9.663  -19.919 -6.989  0.50 62.89  ? 303  TRP A CD2 1 
ATOM   272  N  NE1 . TRP A 1 40  ? -8.830  -21.991 -7.192  0.50 65.87  ? 303  TRP A NE1 1 
ATOM   273  C  CE2 . TRP A 1 40  ? -9.756  -21.126 -7.713  0.50 62.77  ? 303  TRP A CE2 1 
ATOM   274  C  CE3 . TRP A 1 40  ? -10.518 -18.863 -7.325  0.50 61.32  ? 303  TRP A CE3 1 
ATOM   275  C  CZ2 . TRP A 1 40  ? -10.674 -21.302 -8.747  0.50 59.48  ? 303  TRP A CZ2 1 
ATOM   276  C  CZ3 . TRP A 1 40  ? -11.419 -19.035 -8.350  0.50 58.35  ? 303  TRP A CZ3 1 
ATOM   277  C  CH2 . TRP A 1 40  ? -11.497 -20.242 -9.046  0.50 60.42  ? 303  TRP A CH2 1 
ATOM   278  N  N   . ALA A 1 41  ? -8.290  -15.521 -5.391  0.50 67.80  ? 304  ALA A N   1 
ATOM   279  C  CA  . ALA A 1 41  ? -8.648  -14.253 -4.714  0.50 68.35  ? 304  ALA A CA  1 
ATOM   280  C  C   . ALA A 1 41  ? -9.675  -14.548 -3.616  0.50 67.01  ? 304  ALA A C   1 
ATOM   281  O  O   . ALA A 1 41  ? -10.654 -15.269 -3.887  0.50 57.78  ? 304  ALA A O   1 
ATOM   282  C  CB  . ALA A 1 41  ? -9.171  -13.249 -5.712  0.50 69.52  ? 304  ALA A CB  1 
ATOM   283  N  N   . TYR A 1 42  ? -9.439  -14.008 -2.418  0.50 70.19  ? 305  TYR A N   1 
ATOM   284  C  CA  . TYR A 1 42  ? -10.246 -14.249 -1.193  0.50 71.51  ? 305  TYR A CA  1 
ATOM   285  C  C   . TYR A 1 42  ? -10.877 -12.933 -0.732  0.50 69.24  ? 305  TYR A C   1 
ATOM   286  O  O   . TYR A 1 42  ? -10.142 -12.042 -0.263  0.50 67.83  ? 305  TYR A O   1 
ATOM   287  C  CB  . TYR A 1 42  ? -9.374  -14.841 -0.085  0.50 72.25  ? 305  TYR A CB  1 
ATOM   288  C  CG  . TYR A 1 42  ? -9.996  -14.761 1.284   0.50 71.53  ? 305  TYR A CG  1 
ATOM   289  C  CD1 . TYR A 1 42  ? -10.901 -15.718 1.708   0.50 70.04  ? 305  TYR A CD1 1 
ATOM   290  C  CD2 . TYR A 1 42  ? -9.689  -13.722 2.150   0.50 71.64  ? 305  TYR A CD2 1 
ATOM   291  C  CE1 . TYR A 1 42  ? -11.483 -15.652 2.961   0.50 70.91  ? 305  TYR A CE1 1 
ATOM   292  C  CE2 . TYR A 1 42  ? -10.260 -13.643 3.409   0.50 70.69  ? 305  TYR A CE2 1 
ATOM   293  C  CZ  . TYR A 1 42  ? -11.163 -14.610 3.813   0.50 69.15  ? 305  TYR A CZ  1 
ATOM   294  O  OH  . TYR A 1 42  ? -11.739 -14.543 5.046   0.50 70.09  ? 305  TYR A OH  1 
ATOM   295  N  N   . HIS A 1 43  ? -12.204 -12.831 -0.852  0.50 69.41  ? 306  HIS A N   1 
ATOM   296  C  CA  . HIS A 1 43  ? -12.997 -11.601 -0.587  0.50 67.93  ? 306  HIS A CA  1 
ATOM   297  C  C   . HIS A 1 43  ? -13.500 -11.602 0.861   0.50 68.16  ? 306  HIS A C   1 
ATOM   298  O  O   . HIS A 1 43  ? -13.697 -10.497 1.410   0.50 70.12  ? 306  HIS A O   1 
ATOM   299  C  CB  . HIS A 1 43  ? -14.145 -11.497 -1.597  0.50 65.66  ? 306  HIS A CB  1 
ATOM   300  C  CG  . HIS A 1 43  ? -13.686 -11.545 -3.014  0.50 63.07  ? 306  HIS A CG  1 
ATOM   301  N  ND1 . HIS A 1 43  ? -13.609 -12.729 -3.726  0.50 62.54  ? 306  HIS A ND1 1 
ATOM   302  C  CD2 . HIS A 1 43  ? -13.271 -10.567 -3.849  0.50 61.21  ? 306  HIS A CD2 1 
ATOM   303  C  CE1 . HIS A 1 43  ? -13.169 -12.476 -4.943  0.50 62.22  ? 306  HIS A CE1 1 
ATOM   304  N  NE2 . HIS A 1 43  ? -12.955 -11.154 -5.044  0.50 61.71  ? 306  HIS A NE2 1 
ATOM   305  N  N   . GLY A 1 44  ? -13.696 -12.793 1.441   0.50 62.87  ? 307  GLY A N   1 
ATOM   306  C  CA  . GLY A 1 44  ? -14.272 -12.974 2.788   0.50 62.57  ? 307  GLY A CA  1 
ATOM   307  C  C   . GLY A 1 44  ? -14.707 -14.407 3.044   0.50 61.58  ? 307  GLY A C   1 
ATOM   308  O  O   . GLY A 1 44  ? -14.678 -15.221 2.096   0.50 58.57  ? 307  GLY A O   1 
ATOM   309  N  N   . SER A 1 45  ? -15.099 -14.691 4.290   0.50 64.77  ? 308  SER A N   1 
ATOM   310  C  CA  . SER A 1 45  ? -15.502 -16.024 4.809   0.50 66.14  ? 308  SER A CA  1 
ATOM   311  C  C   . SER A 1 45  ? -16.702 -15.851 5.747   0.50 68.62  ? 308  SER A C   1 
ATOM   312  O  O   . SER A 1 45  ? -16.941 -14.704 6.181   0.50 66.24  ? 308  SER A O   1 
ATOM   313  C  CB  . SER A 1 45  ? -14.354 -16.699 5.519   0.50 66.90  ? 308  SER A CB  1 
ATOM   314  O  OG  . SER A 1 45  ? -13.143 -16.551 4.791   0.50 61.76  ? 308  SER A OG  1 
ATOM   315  N  N   . TYR A 1 46  ? -17.411 -16.948 6.045   0.50 73.80  ? 309  TYR A N   1 
ATOM   316  C  CA  . TYR A 1 46  ? -18.631 -16.984 6.898   0.50 79.58  ? 309  TYR A CA  1 
ATOM   317  C  C   . TYR A 1 46  ? -18.925 -18.427 7.333   0.50 85.77  ? 309  TYR A C   1 
ATOM   318  O  O   . TYR A 1 46  ? -18.001 -19.278 7.248   0.50 89.61  ? 309  TYR A O   1 
ATOM   319  C  CB  . TYR A 1 46  ? -19.830 -16.383 6.156   0.50 81.79  ? 309  TYR A CB  1 
ATOM   320  C  CG  . TYR A 1 46  ? -20.437 -17.271 5.097   0.50 85.56  ? 309  TYR A CG  1 
ATOM   321  C  CD1 . TYR A 1 46  ? -21.129 -18.423 5.439   0.50 86.12  ? 309  TYR A CD1 1 
ATOM   322  C  CD2 . TYR A 1 46  ? -20.334 -16.957 3.751   0.50 84.69  ? 309  TYR A CD2 1 
ATOM   323  C  CE1 . TYR A 1 46  ? -21.692 -19.243 4.473   0.50 85.73  ? 309  TYR A CE1 1 
ATOM   324  C  CE2 . TYR A 1 46  ? -20.891 -17.766 2.774   0.50 85.04  ? 309  TYR A CE2 1 
ATOM   325  C  CZ  . TYR A 1 46  ? -21.574 -18.914 3.135   0.50 86.32  ? 309  TYR A CZ  1 
ATOM   326  O  OH  . TYR A 1 46  ? -22.129 -19.714 2.176   0.50 84.77  ? 309  TYR A OH  1 
ATOM   327  N  N   . SER A 1 55  ? -18.725 -41.647 0.068   0.34 45.08  ? 318  SER A N   1 
ATOM   328  C  CA  . SER A 1 55  ? -17.969 -42.924 0.139   0.34 42.83  ? 318  SER A CA  1 
ATOM   329  C  C   . SER A 1 55  ? -18.488 -43.896 -0.929  0.34 40.60  ? 318  SER A C   1 
ATOM   330  O  O   . SER A 1 55  ? -19.686 -43.823 -1.278  0.34 37.63  ? 318  SER A O   1 
ATOM   331  C  CB  . SER A 1 55  ? -18.051 -43.525 1.522   0.34 45.40  ? 318  SER A CB  1 
ATOM   332  O  OG  . SER A 1 55  ? -19.317 -44.133 1.749   0.34 46.69  ? 318  SER A OG  1 
ATOM   333  N  N   . SER A 1 56  ? -17.602 -44.752 -1.441  0.34 37.69  ? 319  SER A N   1 
ATOM   334  C  CA  . SER A 1 56  ? -17.920 -45.824 -2.417  0.34 37.28  ? 319  SER A CA  1 
ATOM   335  C  C   . SER A 1 56  ? -18.482 -47.049 -1.689  0.34 35.15  ? 319  SER A C   1 
ATOM   336  O  O   . SER A 1 56  ? -17.697 -47.834 -1.095  0.34 31.70  ? 319  SER A O   1 
ATOM   337  C  CB  . SER A 1 56  ? -16.718 -46.194 -3.241  0.34 39.12  ? 319  SER A CB  1 
ATOM   338  O  OG  . SER A 1 56  ? -15.842 -47.020 -2.500  0.34 40.79  ? 319  SER A OG  1 
ATOM   339  N  N   . MET A 1 57  ? -19.804 -47.211 -1.764  0.34 31.75  ? 320  MET A N   1 
ATOM   340  C  CA  . MET A 1 57  ? -20.526 -48.405 -1.273  0.34 29.83  ? 320  MET A CA  1 
ATOM   341  C  C   . MET A 1 57  ? -20.159 -49.585 -2.180  0.34 27.00  ? 320  MET A C   1 
ATOM   342  O  O   . MET A 1 57  ? -19.653 -49.345 -3.303  0.34 25.36  ? 320  MET A O   1 
ATOM   343  C  CB  . MET A 1 57  ? -22.033 -48.150 -1.290  0.34 30.85  ? 320  MET A CB  1 
ATOM   344  C  CG  . MET A 1 57  ? -22.406 -46.771 -0.744  0.34 31.93  ? 320  MET A CG  1 
ATOM   345  S  SD  . MET A 1 57  ? -21.710 -46.465 0.903   0.34 32.12  ? 320  MET A SD  1 
ATOM   346  C  CE  . MET A 1 57  ? -22.626 -47.641 1.898   0.34 31.12  ? 320  MET A CE  1 
ATOM   347  N  N   . VAL A 1 58  ? -20.347 -50.808 -1.688  0.50 25.80  ? 321  VAL A N   1 
ATOM   348  C  CA  . VAL A 1 58  ? -20.088 -52.048 -2.464  0.50 25.26  ? 321  VAL A CA  1 
ATOM   349  C  C   . VAL A 1 58  ? -21.410 -52.602 -3.005  0.50 26.43  ? 321  VAL A C   1 
ATOM   350  O  O   . VAL A 1 58  ? -22.398 -52.654 -2.242  0.50 28.08  ? 321  VAL A O   1 
ATOM   351  C  CB  . VAL A 1 58  ? -19.341 -53.111 -1.648  0.50 25.94  ? 321  VAL A CB  1 
ATOM   352  C  CG1 . VAL A 1 58  ? -19.157 -54.373 -2.480  0.50 24.19  ? 321  VAL A CG1 1 
ATOM   353  C  CG2 . VAL A 1 58  ? -18.002 -52.581 -1.159  0.50 28.17  ? 321  VAL A CG2 1 
ATOM   354  N  N   . ASN A 1 59  ? -21.420 -52.954 -4.289  1.00 24.69  ? 322  ASN A N   1 
ATOM   355  C  CA  . ASN A 1 59  ? -22.544 -53.668 -4.910  1.00 24.43  ? 322  ASN A CA  1 
ATOM   356  C  C   . ASN A 1 59  ? -22.475 -55.163 -4.553  1.00 24.34  ? 322  ASN A C   1 
ATOM   357  O  O   . ASN A 1 59  ? -21.638 -55.892 -5.090  1.00 24.55  ? 322  ASN A O   1 
ATOM   358  C  CB  . ASN A 1 59  ? -22.568 -53.458 -6.398  1.00 24.23  ? 322  ASN A CB  1 
ATOM   359  C  CG  . ASN A 1 59  ? -23.805 -54.046 -7.042  1.00 22.93  ? 322  ASN A CG  1 
ATOM   360  O  OD1 . ASN A 1 59  ? -24.253 -55.152 -6.742  1.00 23.88  ? 322  ASN A OD1 1 
ATOM   361  N  ND2 . ASN A 1 59  ? -24.352 -53.312 -8.000  1.00 25.17  ? 322  ASN A ND2 1 
ATOM   362  N  N   . GLY A 1 60  ? -23.317 -55.609 -3.627  1.00 23.25  ? 323  GLY A N   1 
ATOM   363  C  CA  . GLY A 1 60  ? -23.335 -57.011 -3.147  1.00 23.05  ? 323  GLY A CA  1 
ATOM   364  C  C   . GLY A 1 60  ? -23.677 -58.044 -4.189  1.00 23.33  ? 323  GLY A C   1 
ATOM   365  O  O   . GLY A 1 60  ? -23.216 -59.206 -4.103  1.00 24.77  ? 323  GLY A O   1 
ATOM   366  N  N   . VAL A 1 61  ? -24.578 -57.714 -5.140  1.00 23.00  ? 324  VAL A N   1 
ATOM   367  C  CA  . VAL A 1 61  ? -24.890 -58.668 -6.206  1.00 22.01  ? 324  VAL A CA  1 
ATOM   368  C  C   . VAL A 1 61  ? -23.646 -58.939 -7.052  1.00 22.42  ? 324  VAL A C   1 
ATOM   369  O  O   . VAL A 1 61  ? -23.363 -60.122 -7.331  1.00 24.52  ? 324  VAL A O   1 
ATOM   370  C  CB  . VAL A 1 61  ? -26.115 -58.186 -7.028  1.00 21.84  ? 324  VAL A CB  1 
ATOM   371  C  CG1 . VAL A 1 61  ? -26.266 -58.978 -8.287  1.00 22.49  ? 324  VAL A CG1 1 
ATOM   372  C  CG2 . VAL A 1 61  ? -27.401 -58.207 -6.189  1.00 27.86  ? 324  VAL A CG2 1 
ATOM   373  N  N   . VAL A 1 62  ? -22.920 -57.903 -7.473  1.00 19.85  ? 325  VAL A N   1 
ATOM   374  C  CA  . VAL A 1 62  ? -21.717 -58.121 -8.339  1.00 21.92  ? 325  VAL A CA  1 
ATOM   375  C  C   . VAL A 1 62  ? -20.631 -58.834 -7.499  1.00 21.56  ? 325  VAL A C   1 
ATOM   376  O  O   . VAL A 1 62  ? -20.056 -59.816 -7.964  1.00 21.80  ? 325  VAL A O   1 
ATOM   377  C  CB  . VAL A 1 62  ? -21.236 -56.805 -8.963  1.00 23.25  ? 325  VAL A CB  1 
ATOM   378  C  CG1 . VAL A 1 62  ? -19.971 -57.000 -9.784  1.00 21.22  ? 325  VAL A CG1 1 
ATOM   379  C  CG2 . VAL A 1 62  ? -22.285 -56.168 -9.845  1.00 24.51  ? 325  VAL A CG2 1 
ATOM   380  N  N   . ARG A 1 63  ? -20.445 -58.442 -6.252  1.00 21.90  ? 326  ARG A N   1 
ATOM   381  C  CA  . ARG A 1 63  ? -19.363 -59.025 -5.404  1.00 22.88  ? 326  ARG A CA  1 
ATOM   382  C  C   . ARG A 1 63  ? -19.655 -60.500 -5.182  1.00 24.60  ? 326  ARG A C   1 
ATOM   383  O  O   . ARG A 1 63  ? -18.709 -61.278 -5.338  1.00 22.44  ? 326  ARG A O   1 
ATOM   384  C  CB  . ARG A 1 63  ? -19.077 -58.271 -4.121  1.00 23.04  ? 326  ARG A CB  1 
ATOM   385  C  CG  . ARG A 1 63  ? -17.989 -58.922 -3.258  1.00 22.93  ? 326  ARG A CG  1 
ATOM   386  C  CD  . ARG A 1 63  ? -17.290 -57.973 -2.313  1.00 21.79  ? 326  ARG A CD  1 
ATOM   387  N  NE  . ARG A 1 63  ? -18.178 -57.523 -1.253  1.00 21.40  ? 326  ARG A NE  1 
ATOM   388  C  CZ  . ARG A 1 63  ? -17.858 -56.727 -0.246  1.00 22.77  ? 326  ARG A CZ  1 
ATOM   389  N  NH1 . ARG A 1 63  ? -16.606 -56.395 -0.073  1.00 24.76  ? 326  ARG A NH1 1 
ATOM   390  N  NH2 . ARG A 1 63  ? -18.775 -56.305 0.620   1.00 25.26  ? 326  ARG A NH2 1 
ATOM   391  N  N   . LEU A 1 64  ? -20.884 -60.897 -4.825  1.00 22.41  ? 327  LEU A N   1 
ATOM   392  C  CA  . LEU A 1 64  ? -21.130 -62.340 -4.584  1.00 21.76  ? 327  LEU A CA  1 
ATOM   393  C  C   . LEU A 1 64  ? -20.866 -63.177 -5.828  1.00 23.16  ? 327  LEU A C   1 
ATOM   394  O  O   . LEU A 1 64  ? -20.572 -64.363 -5.689  1.00 24.71  ? 327  LEU A O   1 
ATOM   395  C  CB  . LEU A 1 64  ? -22.572 -62.547 -4.083  1.00 22.65  ? 327  LEU A CB  1 
ATOM   396  C  CG  . LEU A 1 64  ? -22.797 -62.190 -2.616  1.00 24.67  ? 327  LEU A CG  1 
ATOM   397  C  CD1 . LEU A 1 64  ? -24.285 -62.292 -2.228  1.00 23.46  ? 327  LEU A CD1 1 
ATOM   398  C  CD2 . LEU A 1 64  ? -21.949 -63.017 -1.664  1.00 25.04  ? 327  LEU A CD2 1 
ATOM   399  N  N   . LEU A 1 65  ? -20.927 -62.599 -7.021  1.00 22.26  ? 328  LEU A N   1 
ATOM   400  C  CA  . LEU A 1 65  ? -20.754 -63.356 -8.302  1.00 22.34  ? 328  LEU A CA  1 
ATOM   401  C  C   . LEU A 1 65  ? -19.345 -63.184 -8.894  1.00 20.74  ? 328  LEU A C   1 
ATOM   402  O  O   . LEU A 1 65  ? -19.068 -63.745 -9.985  1.00 25.61  ? 328  LEU A O   1 
ATOM   403  C  CB  . LEU A 1 65  ? -21.891 -62.953 -9.254  1.00 23.85  ? 328  LEU A CB  1 
ATOM   404  C  CG  . LEU A 1 65  ? -23.293 -63.359 -8.781  1.00 24.40  ? 328  LEU A CG  1 
ATOM   405  C  CD1 . LEU A 1 65  ? -24.389 -62.718 -9.656  1.00 23.95  ? 328  LEU A CD1 1 
ATOM   406  C  CD2 . LEU A 1 65  ? -23.419 -64.860 -8.840  1.00 25.26  ? 328  LEU A CD2 1 
ATOM   407  N  N   . THR A 1 66  ? -18.444 -62.569 -8.151  1.00 19.32  ? 329  THR A N   1 
ATOM   408  C  CA  . THR A 1 66  ? -17.041 -62.406 -8.536  1.00 21.78  ? 329  THR A CA  1 
ATOM   409  C  C   . THR A 1 66  ? -16.115 -62.776 -7.360  1.00 20.58  ? 329  THR A C   1 
ATOM   410  O  O   . THR A 1 66  ? -15.126 -62.057 -7.136  1.00 21.22  ? 329  THR A O   1 
ATOM   411  C  CB  . THR A 1 66  ? -16.796 -60.994 -9.070  1.00 20.84  ? 329  THR A CB  1 
ATOM   412  O  OG1 . THR A 1 66  ? -17.184 -59.966 -8.138  1.00 20.53  ? 329  THR A OG1 1 
ATOM   413  C  CG2 . THR A 1 66  ? -17.524 -60.800 -10.384 1.00 22.52  ? 329  THR A CG2 1 
ATOM   414  N  N   . LYS A 1 67  ? -16.379 -63.899 -6.703  1.00 19.44  ? 330  LYS A N   1 
ATOM   415  C  CA  . LYS A 1 67  ? -15.642 -64.295 -5.481  1.00 21.95  ? 330  LYS A CA  1 
ATOM   416  C  C   . LYS A 1 67  ? -14.125 -64.365 -5.693  1.00 21.76  ? 330  LYS A C   1 
ATOM   417  O  O   . LYS A 1 67  ? -13.375 -63.959 -4.791  1.00 23.74  ? 330  LYS A O   1 
ATOM   418  C  CB  . LYS A 1 67  ? -16.228 -65.594 -4.933  1.00 23.09  ? 330  LYS A CB  1 
ATOM   419  C  CG  . LYS A 1 67  ? -15.673 -66.054 -3.591  1.00 24.56  ? 330  LYS A CG  1 
ATOM   420  C  CD  . LYS A 1 67  ? -16.284 -67.385 -3.170  1.00 26.15  ? 330  LYS A CD  1 
ATOM   421  C  CE  . LYS A 1 67  ? -15.975 -67.584 -1.679  1.00 30.68  ? 330  LYS A CE  1 
ATOM   422  N  NZ  . LYS A 1 67  ? -16.269 -68.963 -1.236  1.00 33.76  ? 330  LYS A NZ  1 
ATOM   423  N  N   . PRO A 1 68  ? -13.571 -64.831 -6.809  1.00 18.35  ? 331  PRO A N   1 
ATOM   424  C  CA  . PRO A 1 68  ? -12.110 -64.950 -6.945  1.00 20.45  ? 331  PRO A CA  1 
ATOM   425  C  C   . PRO A 1 68  ? -11.392 -63.606 -6.739  1.00 22.26  ? 331  PRO A C   1 
ATOM   426  O  O   . PRO A 1 68  ? -10.264 -63.589 -6.233  1.00 24.61  ? 331  PRO A O   1 
ATOM   427  C  CB  . PRO A 1 68  ? -11.870 -65.415 -8.387  1.00 22.98  ? 331  PRO A CB  1 
ATOM   428  C  CG  . PRO A 1 68  ? -13.141 -66.174 -8.736  1.00 26.16  ? 331  PRO A CG  1 
ATOM   429  C  CD  . PRO A 1 68  ? -14.266 -65.527 -7.928  1.00 21.86  ? 331  PRO A CD  1 
ATOM   430  N  N   . TRP A 1 69  ? -12.076 -62.499 -7.076  1.00 21.39  ? 332  TRP A N   1 
ATOM   431  C  CA  . TRP A 1 69  ? -11.517 -61.133 -6.955  1.00 20.80  ? 332  TRP A CA  1 
ATOM   432  C  C   . TRP A 1 69  ? -11.596 -60.624 -5.522  1.00 21.60  ? 332  TRP A C   1 
ATOM   433  O  O   . TRP A 1 69  ? -11.028 -59.529 -5.253  1.00 23.18  ? 332  TRP A O   1 
ATOM   434  C  CB  . TRP A 1 69  ? -12.112 -60.196 -8.006  1.00 20.35  ? 332  TRP A CB  1 
ATOM   435  C  CG  . TRP A 1 69  ? -11.775 -60.660 -9.387  1.00 20.68  ? 332  TRP A CG  1 
ATOM   436  C  CD1 . TRP A 1 69  ? -10.688 -60.238 -10.075 1.00 21.94  ? 332  TRP A CD1 1 
ATOM   437  C  CD2 . TRP A 1 69  ? -12.383 -61.693 -10.206 1.00 22.67  ? 332  TRP A CD2 1 
ATOM   438  N  NE1 . TRP A 1 69  ? -10.620 -60.865 -11.288 1.00 23.26  ? 332  TRP A NE1 1 
ATOM   439  C  CE2 . TRP A 1 69  ? -11.615 -61.783 -11.384 1.00 22.99  ? 332  TRP A CE2 1 
ATOM   440  C  CE3 . TRP A 1 69  ? -13.492 -62.537 -10.109 1.00 22.72  ? 332  TRP A CE3 1 
ATOM   441  C  CZ2 . TRP A 1 69  ? -11.953 -62.633 -12.432 1.00 23.23  ? 332  TRP A CZ2 1 
ATOM   442  C  CZ3 . TRP A 1 69  ? -13.837 -63.368 -11.145 1.00 22.80  ? 332  TRP A CZ3 1 
ATOM   443  C  CH2 . TRP A 1 69  ? -13.026 -63.473 -12.274 1.00 25.22  ? 332  TRP A CH2 1 
ATOM   444  N  N   . ASP A 1 70  ? -12.162 -61.389 -4.555  1.00 21.90  ? 333  ASP A N   1 
ATOM   445  C  CA  . ASP A 1 70  ? -12.202 -60.879 -3.156  1.00 19.60  ? 333  ASP A CA  1 
ATOM   446  C  C   . ASP A 1 70  ? -10.798 -60.858 -2.523  1.00 20.65  ? 333  ASP A C   1 
ATOM   447  O  O   . ASP A 1 70  ? -10.636 -60.208 -1.455  1.00 22.17  ? 333  ASP A O   1 
ATOM   448  C  CB  . ASP A 1 70  ? -13.124 -61.733 -2.293  1.00 20.29  ? 333  ASP A CB  1 
ATOM   449  C  CG  . ASP A 1 70  ? -14.614 -61.683 -2.644  1.00 21.80  ? 333  ASP A CG  1 
ATOM   450  O  OD1 . ASP A 1 70  ? -15.017 -60.788 -3.413  1.00 23.02  ? 333  ASP A OD1 1 
ATOM   451  O  OD2 . ASP A 1 70  ? -15.354 -62.521 -2.061  1.00 22.58  ? 333  ASP A OD2 1 
ATOM   452  N  N   . ILE A 1 71  ? -9.821  -61.550 -3.133  1.00 21.82  ? 334  ILE A N   1 
ATOM   453  C  CA  . ILE A 1 71  ? -8.439  -61.652 -2.622  1.00 23.82  ? 334  ILE A CA  1 
ATOM   454  C  C   . ILE A 1 71  ? -7.448  -60.933 -3.561  1.00 29.26  ? 334  ILE A C   1 
ATOM   455  O  O   . ILE A 1 71  ? -6.223  -61.045 -3.331  1.00 27.92  ? 334  ILE A O   1 
ATOM   456  C  CB  . ILE A 1 71  ? -8.045  -63.111 -2.343  1.00 26.29  ? 334  ILE A CB  1 
ATOM   457  C  CG1 . ILE A 1 71  ? -8.082  -63.953 -3.605  1.00 30.33  ? 334  ILE A CG1 1 
ATOM   458  C  CG2 . ILE A 1 71  ? -8.879  -63.716 -1.223  1.00 31.12  ? 334  ILE A CG2 1 
ATOM   459  C  CD1 . ILE A 1 71  ? -7.336  -65.258 -3.498  1.00 35.15  ? 334  ILE A CD1 1 
ATOM   460  N  N   . ILE A 1 72  ? -7.918  -60.116 -4.492  1.00 24.29  ? 335  ILE A N   1 
ATOM   461  C  CA  . ILE A 1 72  ? -7.063  -59.350 -5.425  1.00 23.53  ? 335  ILE A CA  1 
ATOM   462  C  C   . ILE A 1 72  ? -7.093  -57.899 -4.992  1.00 25.12  ? 335  ILE A C   1 
ATOM   463  O  O   . ILE A 1 72  ? -8.070  -57.172 -5.241  1.00 25.43  ? 335  ILE A O   1 
ATOM   464  C  CB  . ILE A 1 72  ? -7.546  -59.565 -6.865  1.00 25.36  ? 335  ILE A CB  1 
ATOM   465  C  CG1 . ILE A 1 72  ? -7.579  -61.061 -7.233  1.00 30.42  ? 335  ILE A CG1 1 
ATOM   466  C  CG2 . ILE A 1 72  ? -6.770  -58.656 -7.827  1.00 24.51  ? 335  ILE A CG2 1 
ATOM   467  C  CD1 . ILE A 1 72  ? -6.685  -61.544 -8.299  1.00 38.25  ? 335  ILE A CD1 1 
ATOM   468  N  N   . PRO A 1 73  ? -5.981  -57.365 -4.437  1.00 26.40  ? 336  PRO A N   1 
ATOM   469  C  CA  . PRO A 1 73  ? -5.969  -56.002 -3.905  1.00 28.34  ? 336  PRO A CA  1 
ATOM   470  C  C   . PRO A 1 73  ? -6.249  -54.913 -4.931  1.00 27.65  ? 336  PRO A C   1 
ATOM   471  O  O   . PRO A 1 73  ? -6.896  -53.949 -4.585  1.00 26.21  ? 336  PRO A O   1 
ATOM   472  C  CB  . PRO A 1 73  ? -4.527  -55.804 -3.399  1.00 30.84  ? 336  PRO A CB  1 
ATOM   473  C  CG  . PRO A 1 73  ? -4.104  -57.227 -3.072  1.00 35.40  ? 336  PRO A CG  1 
ATOM   474  C  CD  . PRO A 1 73  ? -4.775  -58.129 -4.104  1.00 28.99  ? 336  PRO A CD  1 
ATOM   475  N  N   . MET A 1 74  ? -5.886  -55.143 -6.196  1.00 28.18  ? 337  MET A N   1 
ATOM   476  C  CA  . MET A 1 74  ? -6.182  -54.098 -7.206  1.00 30.30  ? 337  MET A CA  1 
ATOM   477  C  C   . MET A 1 74  ? -7.707  -53.926 -7.378  1.00 32.58  ? 337  MET A C   1 
ATOM   478  O  O   . MET A 1 74  ? -8.145  -52.808 -7.661  1.00 30.06  ? 337  MET A O   1 
ATOM   479  C  CB  . MET A 1 74  ? -5.489  -54.366 -8.541  1.00 32.54  ? 337  MET A CB  1 
ATOM   480  C  CG  . MET A 1 74  ? -3.946  -54.352 -8.446  1.00 38.55  ? 337  MET A CG  1 
ATOM   481  S  SD  . MET A 1 74  ? -3.357  -52.635 -8.060  1.00 49.87  ? 337  MET A SD  1 
ATOM   482  C  CE  . MET A 1 74  ? -4.396  -51.633 -9.122  1.00 45.34  ? 337  MET A CE  1 
ATOM   483  N  N   . VAL A 1 75  ? -8.508  -54.957 -7.093  1.00 26.90  ? 338  VAL A N   1 
ATOM   484  C  CA  . VAL A 1 75  ? -9.999  -54.849 -7.117  1.00 23.89  ? 338  VAL A CA  1 
ATOM   485  C  C   . VAL A 1 75  ? -10.461 -54.352 -5.758  1.00 25.89  ? 338  VAL A C   1 
ATOM   486  O  O   . VAL A 1 75  ? -11.216 -53.393 -5.704  1.00 29.15  ? 338  VAL A O   1 
ATOM   487  C  CB  . VAL A 1 75  ? -10.668 -56.214 -7.416  1.00 23.16  ? 338  VAL A CB  1 
ATOM   488  C  CG1 . VAL A 1 75  ? -12.154 -56.175 -7.092  1.00 23.55  ? 338  VAL A CG1 1 
ATOM   489  C  CG2 . VAL A 1 75  ? -10.356 -56.707 -8.834  1.00 25.71  ? 338  VAL A CG2 1 
ATOM   490  N  N   . THR A 1 76  ? -10.030 -54.977 -4.679  1.00 25.21  ? 339  THR A N   1 
ATOM   491  C  CA  . THR A 1 76  ? -10.657 -54.715 -3.373  1.00 24.66  ? 339  THR A CA  1 
ATOM   492  C  C   . THR A 1 76  ? -10.304 -53.325 -2.881  1.00 26.71  ? 339  THR A C   1 
ATOM   493  O  O   . THR A 1 76  ? -11.184 -52.713 -2.223  1.00 28.97  ? 339  THR A O   1 
ATOM   494  C  CB  . THR A 1 76  ? -10.288 -55.764 -2.325  1.00 26.45  ? 339  THR A CB  1 
ATOM   495  O  OG1 . THR A 1 76  ? -8.879  -55.700 -2.120  1.00 25.83  ? 339  THR A OG1 1 
ATOM   496  C  CG2 . THR A 1 76  ? -10.752 -57.141 -2.743  1.00 26.88  ? 339  THR A CG2 1 
ATOM   497  N  N   . GLN A 1 77  ? -9.111  -52.810 -3.209  1.00 27.25  ? 340  GLN A N   1 
ATOM   498  C  CA  . GLN A 1 77  ? -8.687  -51.444 -2.800  1.00 29.03  ? 340  GLN A CA  1 
ATOM   499  C  C   . GLN A 1 77  ? -9.526  -50.365 -3.487  1.00 30.78  ? 340  GLN A C   1 
ATOM   500  O  O   . GLN A 1 77  ? -9.632  -49.319 -2.885  1.00 28.12  ? 340  GLN A O   1 
ATOM   501  C  CB  . GLN A 1 77  ? -7.196  -51.230 -2.996  1.00 33.16  ? 340  GLN A CB  1 
ATOM   502  C  CG  . GLN A 1 77  ? -6.393  -52.162 -2.126  1.00 44.98  ? 340  GLN A CG  1 
ATOM   503  C  CD  . GLN A 1 77  ? -6.262  -51.642 -0.717  1.00 57.32  ? 340  GLN A CD  1 
ATOM   504  O  OE1 . GLN A 1 77  ? -6.813  -50.593 -0.377  1.00 66.88  ? 340  GLN A OE1 1 
ATOM   505  N  NE2 . GLN A 1 77  ? -5.490  -52.353 0.098   1.00 59.06  ? 340  GLN A NE2 1 
ATOM   506  N  N   . MET A 1 78  ? -10.095 -50.594 -4.671  1.00 27.48  ? 341  MET A N   1 
ATOM   507  C  CA  . MET A 1 78  ? -10.871 -49.535 -5.361  1.00 30.63  ? 341  MET A CA  1 
ATOM   508  C  C   . MET A 1 78  ? -12.085 -49.094 -4.532  1.00 28.59  ? 341  MET A C   1 
ATOM   509  O  O   . MET A 1 78  ? -12.498 -47.947 -4.681  1.00 26.80  ? 341  MET A O   1 
ATOM   510  C  CB  . MET A 1 78  ? -11.369 -49.991 -6.730  1.00 30.92  ? 341  MET A CB  1 
ATOM   511  C  CG  . MET A 1 78  ? -10.257 -50.431 -7.658  1.00 39.19  ? 341  MET A CG  1 
ATOM   512  S  SD  . MET A 1 78  ? -10.805 -50.612 -9.423  1.00 41.99  ? 341  MET A SD  1 
ATOM   513  C  CE  . MET A 1 78  ? -12.168 -49.484 -9.337  1.00 28.73  ? 341  MET A CE  1 
ATOM   514  N  N   . ALA A 1 79  ? -12.675 -49.971 -3.709  1.00 27.17  ? 342  ALA A N   1 
ATOM   515  C  CA  . ALA A 1 79  ? -13.900 -49.657 -2.921  1.00 30.97  ? 342  ALA A CA  1 
ATOM   516  C  C   . ALA A 1 79  ? -13.540 -48.939 -1.603  1.00 32.03  ? 342  ALA A C   1 
ATOM   517  O  O   . ALA A 1 79  ? -14.454 -48.471 -0.906  1.00 32.64  ? 342  ALA A O   1 
ATOM   518  C  CB  . ALA A 1 79  ? -14.664 -50.954 -2.667  1.00 32.83  ? 342  ALA A CB  1 
ATOM   519  N  N   . MET A 1 80  ? -12.265 -48.836 -1.219  1.00 33.16  ? 343  MET A N   1 
ATOM   520  C  CA  . MET A 1 80  ? -11.879 -48.250 0.103   1.00 38.17  ? 343  MET A CA  1 
ATOM   521  C  C   . MET A 1 80  ? -11.652 -46.717 0.058   1.00 50.65  ? 343  MET A C   1 
ATOM   522  O  O   . MET A 1 80  ? -11.378 -46.154 -1.028  1.00 48.97  ? 343  MET A O   1 
ATOM   523  C  CB  . MET A 1 80  ? -10.586 -48.910 0.612   1.00 34.78  ? 343  MET A CB  1 
ATOM   524  C  CG  . MET A 1 80  ? -10.656 -50.436 0.739   1.00 35.59  ? 343  MET A CG  1 
ATOM   525  S  SD  . MET A 1 80  ? -12.100 -51.003 1.777   1.00 40.84  ? 343  MET A SD  1 
ATOM   526  C  CE  . MET A 1 80  ? -11.428 -50.737 3.424   1.00 40.56  ? 343  MET A CE  1 
ATOM   527  N  N   . THR A 1 81  ? -11.679 -46.075 1.233   0.50 56.62  ? 344  THR A N   1 
ATOM   528  C  CA  . THR A 1 81  ? -11.200 -44.691 1.460   0.50 57.07  ? 344  THR A CA  1 
ATOM   529  C  C   . THR A 1 81  ? -11.962 -43.666 0.635   0.50 55.63  ? 344  THR A C   1 
ATOM   530  O  O   . THR A 1 81  ? -12.841 -43.004 1.221   0.50 56.54  ? 344  THR A O   1 
ATOM   531  N  N   . LYS A 1 95  ? -4.549  -28.799 -8.371  0.50 79.06  ? 358  LYS A N   1 
ATOM   532  C  CA  . LYS A 1 95  ? -3.713  -27.691 -8.909  0.50 80.01  ? 358  LYS A CA  1 
ATOM   533  C  C   . LYS A 1 95  ? -4.579  -26.436 -9.071  0.50 79.35  ? 358  LYS A C   1 
ATOM   534  O  O   . LYS A 1 95  ? -4.067  -25.429 -9.605  0.50 78.74  ? 358  LYS A O   1 
ATOM   535  C  CB  . LYS A 1 95  ? -3.085  -28.083 -10.251 0.50 81.59  ? 358  LYS A CB  1 
ATOM   536  C  CG  . LYS A 1 95  ? -1.933  -27.192 -10.709 0.50 82.66  ? 358  LYS A CG  1 
ATOM   537  C  CD  . LYS A 1 95  ? -1.690  -27.220 -12.204 0.50 81.86  ? 358  LYS A CD  1 
ATOM   538  C  CE  . LYS A 1 95  ? -1.770  -28.615 -12.784 0.50 82.46  ? 358  LYS A CE  1 
ATOM   539  N  NZ  . LYS A 1 95  ? -0.863  -29.553 -12.082 0.50 81.73  ? 358  LYS A NZ  1 
ATOM   540  N  N   . VAL A 1 96  ? -5.842  -26.497 -8.635  0.50 79.78  ? 359  VAL A N   1 
ATOM   541  C  CA  . VAL A 1 96  ? -6.803  -25.356 -8.721  0.50 78.84  ? 359  VAL A CA  1 
ATOM   542  C  C   . VAL A 1 96  ? -6.068  -24.098 -8.246  0.50 76.98  ? 359  VAL A C   1 
ATOM   543  O  O   . VAL A 1 96  ? -6.277  -23.023 -8.844  0.50 77.67  ? 359  VAL A O   1 
ATOM   544  C  CB  . VAL A 1 96  ? -8.084  -25.610 -7.901  0.50 76.99  ? 359  VAL A CB  1 
ATOM   545  C  CG1 . VAL A 1 96  ? -7.900  -25.242 -6.437  0.50 77.90  ? 359  VAL A CG1 1 
ATOM   546  C  CG2 . VAL A 1 96  ? -9.282  -24.877 -8.486  0.50 75.16  ? 359  VAL A CG2 1 
ATOM   547  N  N   . ASP A 1 97  ? -5.227  -24.242 -7.217  0.50 76.47  ? 360  ASP A N   1 
ATOM   548  C  CA  . ASP A 1 97  ? -4.415  -23.135 -6.647  0.50 75.21  ? 360  ASP A CA  1 
ATOM   549  C  C   . ASP A 1 97  ? -3.058  -23.108 -7.364  0.50 76.24  ? 360  ASP A C   1 
ATOM   550  O  O   . ASP A 1 97  ? -2.056  -23.555 -6.766  0.50 80.07  ? 360  ASP A O   1 
ATOM   551  C  CB  . ASP A 1 97  ? -4.298  -23.263 -5.125  0.50 73.28  ? 360  ASP A CB  1 
ATOM   552  C  CG  . ASP A 1 97  ? -4.379  -21.931 -4.396  0.50 72.15  ? 360  ASP A CG  1 
ATOM   553  O  OD1 . ASP A 1 97  ? -4.176  -20.888 -5.051  0.50 71.26  ? 360  ASP A OD1 1 
ATOM   554  O  OD2 . ASP A 1 97  ? -4.653  -21.943 -3.182  0.50 74.34  ? 360  ASP A OD2 1 
ATOM   555  N  N   . THR A 1 98  ? -3.053  -22.629 -8.613  0.50 76.04  ? 361  THR A N   1 
ATOM   556  C  CA  . THR A 1 98  ? -1.846  -22.322 -9.431  0.50 76.20  ? 361  THR A CA  1 
ATOM   557  C  C   . THR A 1 98  ? -2.207  -21.235 -10.451 0.50 74.12  ? 361  THR A C   1 
ATOM   558  O  O   . THR A 1 98  ? -3.411  -20.966 -10.622 0.50 72.50  ? 361  THR A O   1 
ATOM   559  C  CB  . THR A 1 98  ? -1.284  -23.577 -10.117 0.50 76.34  ? 361  THR A CB  1 
ATOM   560  O  OG1 . THR A 1 98  ? -2.328  -24.201 -10.867 0.50 76.55  ? 361  THR A OG1 1 
ATOM   561  C  CG2 . THR A 1 98  ? -0.696  -24.568 -9.135  0.50 75.27  ? 361  THR A CG2 1 
ATOM   562  N  N   . ARG A 1 99  ? -1.201  -20.624 -11.083 0.50 74.70  ? 362  ARG A N   1 
ATOM   563  C  CA  . ARG A 1 99  ? -1.382  -19.635 -12.181 0.50 79.87  ? 362  ARG A CA  1 
ATOM   564  C  C   . ARG A 1 99  ? -0.715  -20.176 -13.451 0.50 78.49  ? 362  ARG A C   1 
ATOM   565  O  O   . ARG A 1 99  ? 0.053   -21.158 -13.345 0.50 77.09  ? 362  ARG A O   1 
ATOM   566  C  CB  . ARG A 1 99  ? -0.802  -18.271 -11.796 0.50 81.72  ? 362  ARG A CB  1 
ATOM   567  C  CG  . ARG A 1 99  ? 0.676   -18.301 -11.433 0.50 85.52  ? 362  ARG A CG  1 
ATOM   568  C  CD  . ARG A 1 99  ? 1.273   -16.910 -11.345 0.50 89.67  ? 362  ARG A CD  1 
ATOM   569  N  NE  . ARG A 1 99  ? 1.108   -16.175 -12.591 0.50 92.07  ? 362  ARG A NE  1 
ATOM   570  C  CZ  . ARG A 1 99  ? 1.720   -15.034 -12.881 0.50 93.88  ? 362  ARG A CZ  1 
ATOM   571  N  NH1 . ARG A 1 99  ? 1.501   -14.446 -14.045 0.50 94.17  ? 362  ARG A NH1 1 
ATOM   572  N  NH2 . ARG A 1 99  ? 2.549   -14.486 -12.010 0.50 95.74  ? 362  ARG A NH2 1 
ATOM   573  N  N   . THR A 1 100 ? -1.011  -19.563 -14.600 0.50 73.20  ? 363  THR A N   1 
ATOM   574  C  CA  . THR A 1 100 ? -0.423  -19.901 -15.923 0.50 72.93  ? 363  THR A CA  1 
ATOM   575  C  C   . THR A 1 100 ? 0.108   -18.622 -16.577 0.50 71.70  ? 363  THR A C   1 
ATOM   576  O  O   . THR A 1 100 ? -0.710  -17.749 -16.917 0.50 73.52  ? 363  THR A O   1 
ATOM   577  C  CB  . THR A 1 100 ? -1.451  -20.600 -16.821 0.50 73.44  ? 363  THR A CB  1 
ATOM   578  O  OG1 . THR A 1 100 ? -2.206  -21.509 -16.019 0.50 71.26  ? 363  THR A OG1 1 
ATOM   579  C  CG2 . THR A 1 100 ? -0.810  -21.336 -17.978 0.50 72.99  ? 363  THR A CG2 1 
ATOM   580  N  N   . GLN A 1 101 ? 1.428   -18.514 -16.746 0.50 75.33  ? 364  GLN A N   1 
ATOM   581  C  CA  . GLN A 1 101 ? 2.067   -17.352 -17.417 0.50 77.04  ? 364  GLN A CA  1 
ATOM   582  C  C   . GLN A 1 101 ? 1.307   -17.053 -18.716 0.50 73.11  ? 364  GLN A C   1 
ATOM   583  O  O   . GLN A 1 101 ? 0.899   -18.005 -19.405 0.50 71.45  ? 364  GLN A O   1 
ATOM   584  C  CB  . GLN A 1 101 ? 3.553   -17.609 -17.679 0.50 78.93  ? 364  GLN A CB  1 
ATOM   585  C  CG  . GLN A 1 101 ? 4.095   -16.823 -18.867 0.50 83.66  ? 364  GLN A CG  1 
ATOM   586  C  CD  . GLN A 1 101 ? 5.365   -16.065 -18.559 0.50 87.58  ? 364  GLN A CD  1 
ATOM   587  O  OE1 . GLN A 1 101 ? 6.446   -16.407 -19.034 0.50 94.39  ? 364  GLN A OE1 1 
ATOM   588  N  NE2 . GLN A 1 101 ? 5.240   -15.012 -17.765 0.50 86.64  ? 364  GLN A NE2 1 
ATOM   589  N  N   . GLU A 1 102 ? 1.110   -15.771 -19.020 0.50 71.25  ? 365  GLU A N   1 
ATOM   590  C  CA  . GLU A 1 102 ? 0.474   -15.297 -20.274 0.50 68.97  ? 365  GLU A CA  1 
ATOM   591  C  C   . GLU A 1 102 ? 1.298   -15.802 -21.455 0.50 63.13  ? 365  GLU A C   1 
ATOM   592  O  O   . GLU A 1 102 ? 2.525   -15.705 -21.454 0.50 57.78  ? 365  GLU A O   1 
ATOM   593  C  CB  . GLU A 1 102 ? 0.377   -13.769 -20.254 0.50 75.12  ? 365  GLU A CB  1 
ATOM   594  C  CG  . GLU A 1 102 ? -0.165  -13.163 -21.539 0.50 81.92  ? 365  GLU A CG  1 
ATOM   595  C  CD  . GLU A 1 102 ? -1.668  -12.931 -21.561 0.50 87.01  ? 365  GLU A CD  1 
ATOM   596  O  OE1 . GLU A 1 102 ? -2.130  -12.126 -22.403 0.50 89.59  ? 365  GLU A OE1 1 
ATOM   597  O  OE2 . GLU A 1 102 ? -2.374  -13.554 -20.738 0.50 89.06  ? 365  GLU A OE2 1 
ATOM   598  N  N   . PRO A 1 103 ? 0.650   -16.382 -22.491 0.50 56.35  ? 366  PRO A N   1 
ATOM   599  C  CA  . PRO A 1 103 ? 1.360   -16.804 -23.695 0.50 53.88  ? 366  PRO A CA  1 
ATOM   600  C  C   . PRO A 1 103 ? 2.000   -15.589 -24.380 0.50 52.47  ? 366  PRO A C   1 
ATOM   601  O  O   . PRO A 1 103 ? 1.555   -14.487 -24.130 0.50 49.72  ? 366  PRO A O   1 
ATOM   602  C  CB  . PRO A 1 103 ? 0.267   -17.442 -24.570 0.50 54.22  ? 366  PRO A CB  1 
ATOM   603  C  CG  . PRO A 1 103 ? -0.848  -17.779 -23.592 0.50 53.44  ? 366  PRO A CG  1 
ATOM   604  C  CD  . PRO A 1 103 ? -0.788  -16.678 -22.554 0.50 55.01  ? 366  PRO A CD  1 
ATOM   605  N  N   . LYS A 1 104 ? 3.013   -15.829 -25.217 0.50 50.99  ? 367  LYS A N   1 
ATOM   606  C  CA  . LYS A 1 104 ? 3.759   -14.790 -25.973 0.50 52.76  ? 367  LYS A CA  1 
ATOM   607  C  C   . LYS A 1 104 ? 2.922   -14.354 -27.180 0.50 53.74  ? 367  LYS A C   1 
ATOM   608  O  O   . LYS A 1 104 ? 2.005   -15.103 -27.569 0.50 51.40  ? 367  LYS A O   1 
ATOM   609  C  CB  . LYS A 1 104 ? 5.125   -15.336 -26.406 0.50 54.88  ? 367  LYS A CB  1 
ATOM   610  C  CG  . LYS A 1 104 ? 5.987   -15.900 -25.280 0.50 55.78  ? 367  LYS A CG  1 
ATOM   611  C  CD  . LYS A 1 104 ? 7.361   -16.363 -25.728 0.50 55.97  ? 367  LYS A CD  1 
ATOM   612  C  CE  . LYS A 1 104 ? 8.266   -16.748 -24.576 0.50 56.27  ? 367  LYS A CE  1 
ATOM   613  N  NZ  . LYS A 1 104 ? 8.236   -15.725 -23.504 0.50 58.67  ? 367  LYS A NZ  1 
ATOM   614  N  N   . GLU A 1 105 ? 3.258   -13.203 -27.767 1.00 49.90  ? 368  GLU A N   1 
ATOM   615  C  CA  . GLU A 1 105 ? 2.470   -12.582 -28.861 1.00 56.66  ? 368  GLU A CA  1 
ATOM   616  C  C   . GLU A 1 105 ? 2.329   -13.524 -30.058 1.00 49.18  ? 368  GLU A C   1 
ATOM   617  O  O   . GLU A 1 105 ? 1.215   -13.539 -30.628 1.00 49.46  ? 368  GLU A O   1 
ATOM   618  C  CB  . GLU A 1 105 ? 3.098   -11.245 -29.283 1.00 59.78  ? 368  GLU A CB  1 
ATOM   619  C  CG  . GLU A 1 105 ? 3.058   -10.203 -28.167 1.00 70.99  ? 368  GLU A CG  1 
ATOM   620  C  CD  . GLU A 1 105 ? 1.691   -9.939  -27.553 1.00 70.60  ? 368  GLU A CD  1 
ATOM   621  O  OE1 . GLU A 1 105 ? 0.725   -9.769  -28.324 1.00 78.67  ? 368  GLU A OE1 1 
ATOM   622  O  OE2 . GLU A 1 105 ? 1.586   -9.926  -26.313 1.00 64.62  ? 368  GLU A OE2 1 
ATOM   623  N  N   . GLY A 1 106 ? 3.409   -14.208 -30.457 1.00 42.71  ? 369  GLY A N   1 
ATOM   624  C  CA  . GLY A 1 106 ? 3.363   -15.224 -31.521 1.00 39.77  ? 369  GLY A CA  1 
ATOM   625  C  C   . GLY A 1 106 ? 2.300   -16.294 -31.196 1.00 41.33  ? 369  GLY A C   1 
ATOM   626  O  O   . GLY A 1 106 ? 1.468   -16.591 -32.094 1.00 41.74  ? 369  GLY A O   1 
ATOM   627  N  N   . THR A 1 107 ? 2.330   -16.834 -29.979 1.00 40.83  ? 370  THR A N   1 
ATOM   628  C  CA  . THR A 1 107 ? 1.395   -17.890 -29.488 1.00 44.32  ? 370  THR A CA  1 
ATOM   629  C  C   . THR A 1 107 ? -0.051  -17.389 -29.561 1.00 47.51  ? 370  THR A C   1 
ATOM   630  O  O   . THR A 1 107 ? -0.872  -18.086 -30.182 1.00 39.53  ? 370  THR A O   1 
ATOM   631  C  CB  . THR A 1 107 ? 1.745   -18.371 -28.081 1.00 46.33  ? 370  THR A CB  1 
ATOM   632  O  OG1 . THR A 1 107 ? 3.127   -18.721 -28.118 1.00 41.32  ? 370  THR A OG1 1 
ATOM   633  C  CG2 . THR A 1 107 ? 0.936   -19.584 -27.654 1.00 46.65  ? 370  THR A CG2 1 
ATOM   634  N  N   . LYS A 1 108 ? -0.328  -16.199 -29.009 1.00 51.72  ? 371  LYS A N   1 
ATOM   635  C  CA  . LYS A 1 108 ? -1.666  -15.518 -28.998 1.00 46.98  ? 371  LYS A CA  1 
ATOM   636  C  C   . LYS A 1 108 ? -2.206  -15.323 -30.417 1.00 49.26  ? 371  LYS A C   1 
ATOM   637  O  O   . LYS A 1 108 ? -3.377  -15.647 -30.625 1.00 49.96  ? 371  LYS A O   1 
ATOM   638  C  CB  . LYS A 1 108 ? -1.581  -14.214 -28.206 1.00 53.14  ? 371  LYS A CB  1 
ATOM   639  C  CG  . LYS A 1 108 ? -1.339  -14.430 -26.720 1.00 54.37  ? 371  LYS A CG  1 
ATOM   640  C  CD  . LYS A 1 108 ? -1.546  -13.197 -25.867 1.00 61.25  ? 371  LYS A CD  1 
ATOM   641  C  CE  . LYS A 1 108 ? -0.385  -12.228 -25.903 1.00 73.96  ? 371  LYS A CE  1 
ATOM   642  N  NZ  . LYS A 1 108 ? -0.427  -11.277 -24.760 1.00 74.67  ? 371  LYS A NZ  1 
ATOM   643  N  N   . LYS A 1 109 ? -1.375  -14.891 -31.369 1.00 43.55  ? 372  LYS A N   1 
ATOM   644  C  CA  . LYS A 1 109 ? -1.751  -14.750 -32.796 1.00 49.65  ? 372  LYS A CA  1 
ATOM   645  C  C   . LYS A 1 109 ? -2.078  -16.133 -33.380 1.00 44.82  ? 372  LYS A C   1 
ATOM   646  O  O   . LYS A 1 109 ? -3.032  -16.219 -34.185 1.00 47.91  ? 372  LYS A O   1 
ATOM   647  C  CB  . LYS A 1 109 ? -0.620  -14.059 -33.572 1.00 45.66  ? 372  LYS A CB  1 
ATOM   648  C  CG  . LYS A 1 109 ? -0.943  -13.623 -34.993 1.00 59.07  ? 372  LYS A CG  1 
ATOM   649  C  CD  . LYS A 1 109 ? -1.976  -12.489 -35.081 1.00 70.67  ? 372  LYS A CD  1 
ATOM   650  C  CE  . LYS A 1 109 ? -1.450  -11.149 -34.601 1.00 74.74  ? 372  LYS A CE  1 
ATOM   651  N  NZ  . LYS A 1 109 ? -2.524  -10.130 -34.583 1.00 78.80  ? 372  LYS A NZ  1 
ATOM   652  N  N   . LEU A 1 110 ? -1.280  -17.164 -33.060 1.00 43.41  ? 373  LEU A N   1 
ATOM   653  C  CA  . LEU A 1 110 ? -1.487  -18.537 -33.619 1.00 43.84  ? 373  LEU A CA  1 
ATOM   654  C  C   . LEU A 1 110 ? -2.838  -19.053 -33.100 1.00 31.71  ? 373  LEU A C   1 
ATOM   655  O  O   . LEU A 1 110 ? -3.639  -19.559 -33.900 1.00 36.15  ? 373  LEU A O   1 
ATOM   656  C  CB  . LEU A 1 110 ? -0.351  -19.479 -33.198 1.00 40.64  ? 373  LEU A CB  1 
ATOM   657  C  CG  . LEU A 1 110 ? 0.983   -19.244 -33.910 1.00 38.52  ? 373  LEU A CG  1 
ATOM   658  C  CD1 . LEU A 1 110 ? 2.142   -19.893 -33.152 1.00 40.59  ? 373  LEU A CD1 1 
ATOM   659  C  CD2 . LEU A 1 110 ? 0.902   -19.739 -35.347 1.00 39.48  ? 373  LEU A CD2 1 
ATOM   660  N  N   . MET A 1 111 ? -3.089  -18.860 -31.829 1.00 29.08  ? 374  MET A N   1 
ATOM   661  C  CA  . MET A 1 111 ? -4.350  -19.357 -31.229 1.00 33.18  ? 374  MET A CA  1 
ATOM   662  C  C   . MET A 1 111 ? -5.583  -18.636 -31.833 1.00 36.50  ? 374  MET A C   1 
ATOM   663  O  O   . MET A 1 111 ? -6.599  -19.312 -32.113 1.00 33.85  ? 374  MET A O   1 
ATOM   664  C  CB  . MET A 1 111 ? -4.320  -19.231 -29.694 1.00 37.04  ? 374  MET A CB  1 
ATOM   665  C  CG  . MET A 1 111 ? -3.310  -20.183 -29.041 1.00 36.34  ? 374  MET A CG  1 
ATOM   666  S  SD  . MET A 1 111 ? -3.446  -20.356 -27.259 1.00 42.72  ? 374  MET A SD  1 
ATOM   667  C  CE  . MET A 1 111 ? -3.136  -18.652 -26.803 1.00 43.84  ? 374  MET A CE  1 
ATOM   668  N  N   . LYS A 1 112 ? -5.499  -17.311 -32.020 0.50 37.09  ? 375  LYS A N   1 
ATOM   669  C  CA  . LYS A 1 112 ? -6.628  -16.460 -32.491 0.50 38.52  ? 375  LYS A CA  1 
ATOM   670  C  C   . LYS A 1 112 ? -6.983  -16.828 -33.933 0.50 38.60  ? 375  LYS A C   1 
ATOM   671  O  O   . LYS A 1 112 ? -8.187  -17.032 -34.205 0.50 39.29  ? 375  LYS A O   1 
ATOM   672  C  CB  . LYS A 1 112 ? -6.273  -14.971 -32.381 0.50 42.44  ? 375  LYS A CB  1 
ATOM   673  C  CG  . LYS A 1 112 ? -7.369  -14.001 -32.810 0.50 43.26  ? 375  LYS A CG  1 
ATOM   674  C  CD  . LYS A 1 112 ? -7.066  -12.561 -32.433 0.50 44.94  ? 375  LYS A CD  1 
ATOM   675  C  CE  . LYS A 1 112 ? -8.136  -11.585 -32.875 0.50 45.14  ? 375  LYS A CE  1 
ATOM   676  N  NZ  . LYS A 1 112 ? -9.378  -11.762 -32.089 0.50 46.26  ? 375  LYS A NZ  1 
ATOM   677  N  N   . ILE A 1 113 ? -5.977  -16.926 -34.810 1.00 36.47  ? 376  ILE A N   1 
ATOM   678  C  CA  . ILE A 1 113 ? -6.175  -17.301 -36.244 1.00 36.92  ? 376  ILE A CA  1 
ATOM   679  C  C   . ILE A 1 113 ? -6.763  -18.711 -36.300 1.00 40.57  ? 376  ILE A C   1 
ATOM   680  O  O   . ILE A 1 113 ? -7.668  -18.951 -37.144 1.00 35.67  ? 376  ILE A O   1 
ATOM   681  C  CB  . ILE A 1 113 ? -4.874  -17.252 -37.067 1.00 35.18  ? 376  ILE A CB  1 
ATOM   682  C  CG1 . ILE A 1 113 ? -4.338  -15.832 -37.200 1.00 44.54  ? 376  ILE A CG1 1 
ATOM   683  C  CG2 . ILE A 1 113 ? -5.018  -17.901 -38.434 1.00 36.51  ? 376  ILE A CG2 1 
ATOM   684  C  CD1 . ILE A 1 113 ? -2.927  -15.810 -37.741 1.00 47.26  ? 376  ILE A CD1 1 
ATOM   685  N  N   . THR A 1 114 ? -6.234  -19.622 -35.477 1.00 34.05  ? 377  THR A N   1 
ATOM   686  C  CA  . THR A 1 114 ? -6.683  -21.034 -35.507 1.00 32.81  ? 377  THR A CA  1 
ATOM   687  C  C   . THR A 1 114 ? -8.127  -21.140 -34.967 1.00 30.16  ? 377  THR A C   1 
ATOM   688  O  O   . THR A 1 114 ? -8.958  -21.782 -35.637 1.00 31.09  ? 377  THR A O   1 
ATOM   689  C  CB  . THR A 1 114 ? -5.687  -21.932 -34.780 1.00 34.03  ? 377  THR A CB  1 
ATOM   690  O  OG1 . THR A 1 114 ? -4.431  -21.761 -35.451 1.00 33.29  ? 377  THR A OG1 1 
ATOM   691  C  CG2 . THR A 1 114 ? -6.082  -23.386 -34.883 1.00 29.87  ? 377  THR A CG2 1 
ATOM   692  N  N   . ALA A 1 115 ? -8.428  -20.487 -33.863 1.00 29.65  ? 378  ALA A N   1 
ATOM   693  C  CA  . ALA A 1 115 ? -9.785  -20.491 -33.248 1.00 33.54  ? 378  ALA A CA  1 
ATOM   694  C  C   . ALA A 1 115 ? -10.831 -19.909 -34.212 1.00 38.81  ? 378  ALA A C   1 
ATOM   695  O  O   . ALA A 1 115 ? -11.896 -20.537 -34.454 1.00 35.14  ? 378  ALA A O   1 
ATOM   696  C  CB  . ALA A 1 115 ? -9.763  -19.747 -31.967 1.00 33.40  ? 378  ALA A CB  1 
ATOM   697  N  N   . GLU A 1 116 ? -10.533 -18.767 -34.819 1.00 37.26  ? 379  GLU A N   1 
ATOM   698  C  CA  . GLU A 1 116 ? -11.441 -18.112 -35.800 1.00 39.05  ? 379  GLU A CA  1 
ATOM   699  C  C   . GLU A 1 116 ? -11.752 -19.104 -36.920 1.00 37.60  ? 379  GLU A C   1 
ATOM   700  O  O   . GLU A 1 116 ? -12.934 -19.302 -37.256 1.00 35.92  ? 379  GLU A O   1 
ATOM   701  C  CB  . GLU A 1 116 ? -10.731 -16.850 -36.319 1.00 40.68  ? 379  GLU A CB  1 
ATOM   702  C  CG  . GLU A 1 116 ? -11.565 -15.973 -37.225 1.00 55.55  ? 379  GLU A CG  1 
ATOM   703  C  CD  . GLU A 1 116 ? -10.843 -14.689 -37.618 1.00 55.88  ? 379  GLU A CD  1 
ATOM   704  O  OE1 . GLU A 1 116 ? -10.119 -14.135 -36.754 1.00 64.44  ? 379  GLU A OE1 1 
ATOM   705  O  OE2 . GLU A 1 116 ? -10.974 -14.283 -38.786 1.00 61.33  ? 379  GLU A OE2 1 
ATOM   706  N  N   . TRP A 1 117 ? -10.727 -19.762 -37.455 1.00 34.92  ? 380  TRP A N   1 
ATOM   707  C  CA  . TRP A 1 117 ? -10.867 -20.700 -38.579 1.00 34.80  ? 380  TRP A CA  1 
ATOM   708  C  C   . TRP A 1 117 ? -11.730 -21.895 -38.119 1.00 35.29  ? 380  TRP A C   1 
ATOM   709  O  O   . TRP A 1 117 ? -12.566 -22.385 -38.915 1.00 32.41  ? 380  TRP A O   1 
ATOM   710  C  CB  . TRP A 1 117 ? -9.476  -21.155 -39.024 1.00 34.56  ? 380  TRP A CB  1 
ATOM   711  C  CG  . TRP A 1 117 ? -9.545  -22.207 -40.052 1.00 28.58  ? 380  TRP A CG  1 
ATOM   712  C  CD1 . TRP A 1 117 ? -9.633  -22.018 -41.390 1.00 29.73  ? 380  TRP A CD1 1 
ATOM   713  C  CD2 . TRP A 1 117 ? -9.511  -23.630 -39.841 1.00 32.35  ? 380  TRP A CD2 1 
ATOM   714  N  NE1 . TRP A 1 117 ? -9.667  -23.204 -42.025 1.00 34.38  ? 380  TRP A NE1 1 
ATOM   715  C  CE2 . TRP A 1 117 ? -9.603  -24.223 -41.098 1.00 31.05  ? 380  TRP A CE2 1 
ATOM   716  C  CE3 . TRP A 1 117 ? -9.392  -24.453 -38.722 1.00 34.56  ? 380  TRP A CE3 1 
ATOM   717  C  CZ2 . TRP A 1 117 ? -9.579  -25.596 -41.288 1.00 36.73  ? 380  TRP A CZ2 1 
ATOM   718  C  CZ3 . TRP A 1 117 ? -9.399  -25.812 -38.904 1.00 29.52  ? 380  TRP A CZ3 1 
ATOM   719  C  CH2 . TRP A 1 117 ? -9.506  -26.381 -40.165 1.00 33.36  ? 380  TRP A CH2 1 
ATOM   720  N  N   . LEU A 1 118 ? -11.473 -22.376 -36.909 1.00 31.58  ? 381  LEU A N   1 
ATOM   721  C  CA  . LEU A 1 118 ? -12.064 -23.635 -36.410 1.00 32.88  ? 381  LEU A CA  1 
ATOM   722  C  C   . LEU A 1 118 ? -13.564 -23.412 -36.138 1.00 29.80  ? 381  LEU A C   1 
ATOM   723  O  O   . LEU A 1 118 ? -14.354 -24.253 -36.546 1.00 30.94  ? 381  LEU A O   1 
ATOM   724  C  CB  . LEU A 1 118 ? -11.326 -24.100 -35.149 1.00 30.06  ? 381  LEU A CB  1 
ATOM   725  C  CG  . LEU A 1 118 ? -11.734 -25.493 -34.667 1.00 31.40  ? 381  LEU A CG  1 
ATOM   726  C  CD1 . LEU A 1 118 ? -11.600 -26.515 -35.786 1.00 33.65  ? 381  LEU A CD1 1 
ATOM   727  C  CD2 . LEU A 1 118 ? -10.960 -25.894 -33.419 1.00 35.20  ? 381  LEU A CD2 1 
ATOM   728  N  N   . TRP A 1 119 ? -13.934 -22.296 -35.505 1.00 33.18  ? 382  TRP A N   1 
ATOM   729  C  CA  . TRP A 1 119 ? -15.381 -21.959 -35.280 1.00 34.29  ? 382  TRP A CA  1 
ATOM   730  C  C   . TRP A 1 119 ? -16.127 -21.908 -36.624 1.00 37.48  ? 382  TRP A C   1 
ATOM   731  O  O   . TRP A 1 119 ? -17.210 -22.536 -36.752 1.00 35.68  ? 382  TRP A O   1 
ATOM   732  C  CB  . TRP A 1 119 ? -15.544 -20.710 -34.446 1.00 32.26  ? 382  TRP A CB  1 
ATOM   733  C  CG  . TRP A 1 119 ? -15.389 -20.888 -32.978 1.00 28.62  ? 382  TRP A CG  1 
ATOM   734  C  CD1 . TRP A 1 119 ? -14.586 -20.156 -32.181 1.00 28.55  ? 382  TRP A CD1 1 
ATOM   735  C  CD2 . TRP A 1 119 ? -16.025 -21.846 -32.108 1.00 29.91  ? 382  TRP A CD2 1 
ATOM   736  N  NE1 . TRP A 1 119 ? -14.699 -20.536 -30.882 1.00 27.93  ? 382  TRP A NE1 1 
ATOM   737  C  CE2 . TRP A 1 119 ? -15.560 -21.591 -30.811 1.00 27.89  ? 382  TRP A CE2 1 
ATOM   738  C  CE3 . TRP A 1 119 ? -16.975 -22.850 -32.270 1.00 31.65  ? 382  TRP A CE3 1 
ATOM   739  C  CZ2 . TRP A 1 119 ? -15.954 -22.314 -29.702 1.00 27.33  ? 382  TRP A CZ2 1 
ATOM   740  C  CZ3 . TRP A 1 119 ? -17.380 -23.562 -31.165 1.00 29.05  ? 382  TRP A CZ3 1 
ATOM   741  C  CH2 . TRP A 1 119 ? -16.872 -23.302 -29.904 1.00 29.26  ? 382  TRP A CH2 1 
ATOM   742  N  N   . LYS A 1 120 ? -15.541 -21.244 -37.626 0.50 38.22  ? 383  LYS A N   1 
ATOM   743  C  CA  . LYS A 1 120 ? -16.098 -21.184 -39.003 0.50 37.73  ? 383  LYS A CA  1 
ATOM   744  C  C   . LYS A 1 120 ? -16.251 -22.594 -39.580 0.50 36.65  ? 383  LYS A C   1 
ATOM   745  O  O   . LYS A 1 120 ? -17.310 -22.861 -40.166 0.50 34.39  ? 383  LYS A O   1 
ATOM   746  C  CB  . LYS A 1 120 ? -15.227 -20.315 -39.914 0.50 42.95  ? 383  LYS A CB  1 
ATOM   747  C  CG  . LYS A 1 120 ? -15.383 -18.818 -39.692 0.50 46.10  ? 383  LYS A CG  1 
ATOM   748  C  CD  . LYS A 1 120 ? -14.649 -17.961 -40.701 0.50 49.95  ? 383  LYS A CD  1 
ATOM   749  C  CE  . LYS A 1 120 ? -14.915 -16.485 -40.486 0.50 52.59  ? 383  LYS A CE  1 
ATOM   750  N  NZ  . LYS A 1 120 ? -14.958 -16.156 -39.039 0.50 52.67  ? 383  LYS A NZ  1 
ATOM   751  N  N   . GLU A 1 121 ? -15.250 -23.470 -39.438 1.00 33.85  ? 384  GLU A N   1 
ATOM   752  C  CA  . GLU A 1 121 ? -15.374 -24.838 -39.993 1.00 35.79  ? 384  GLU A CA  1 
ATOM   753  C  C   . GLU A 1 121 ? -16.528 -25.539 -39.261 1.00 32.72  ? 384  GLU A C   1 
ATOM   754  O  O   . GLU A 1 121 ? -17.268 -26.222 -39.932 1.00 33.52  ? 384  GLU A O   1 
ATOM   755  C  CB  . GLU A 1 121 ? -14.148 -25.760 -39.849 1.00 35.28  ? 384  GLU A CB  1 
ATOM   756  C  CG  . GLU A 1 121 ? -13.054 -25.449 -40.796 1.00 43.56  ? 384  GLU A CG  1 
ATOM   757  C  CD  . GLU A 1 121 ? -13.355 -25.490 -42.288 1.00 40.63  ? 384  GLU A CD  1 
ATOM   758  O  OE1 . GLU A 1 121 ? -13.785 -26.545 -42.824 1.00 41.50  ? 384  GLU A OE1 1 
ATOM   759  O  OE2 . GLU A 1 121 ? -13.015 -24.487 -42.928 1.00 44.59  ? 384  GLU A OE2 1 
ATOM   760  N  N   . LEU A 1 122 ? -16.624 -25.390 -37.932 1.00 30.64  ? 385  LEU A N   1 
ATOM   761  C  CA  . LEU A 1 122 ? -17.601 -26.180 -37.146 1.00 31.74  ? 385  LEU A CA  1 
ATOM   762  C  C   . LEU A 1 122 ? -19.017 -25.650 -37.463 1.00 33.36  ? 385  LEU A C   1 
ATOM   763  O  O   . LEU A 1 122 ? -19.975 -26.404 -37.283 1.00 29.51  ? 385  LEU A O   1 
ATOM   764  C  CB  . LEU A 1 122 ? -17.282 -26.039 -35.660 1.00 29.63  ? 385  LEU A CB  1 
ATOM   765  C  CG  . LEU A 1 122 ? -16.008 -26.781 -35.223 1.00 29.92  ? 385  LEU A CG  1 
ATOM   766  C  CD1 . LEU A 1 122 ? -15.688 -26.488 -33.788 1.00 29.13  ? 385  LEU A CD1 1 
ATOM   767  C  CD2 . LEU A 1 122 ? -16.121 -28.266 -35.478 1.00 30.18  ? 385  LEU A CD2 1 
ATOM   768  N  N   . GLY A 1 123 ? -19.090 -24.384 -37.885 1.00 33.16  ? 386  GLY A N   1 
ATOM   769  C  CA  . GLY A 1 123 ? -20.329 -23.631 -38.184 1.00 37.47  ? 386  GLY A CA  1 
ATOM   770  C  C   . GLY A 1 123 ? -20.789 -23.783 -39.618 1.00 41.06  ? 386  GLY A C   1 
ATOM   771  O  O   . GLY A 1 123 ? -21.940 -23.488 -39.851 1.00 42.64  ? 386  GLY A O   1 
ATOM   772  N  N   . LYS A 1 124 ? -19.974 -24.262 -40.559 1.00 42.69  ? 387  LYS A N   1 
ATOM   773  C  CA  . LYS A 1 124 ? -20.401 -24.357 -41.974 1.00 44.66  ? 387  LYS A CA  1 
ATOM   774  C  C   . LYS A 1 124 ? -21.721 -25.132 -42.104 1.00 44.19  ? 387  LYS A C   1 
ATOM   775  O  O   . LYS A 1 124 ? -22.549 -24.757 -42.978 1.00 43.89  ? 387  LYS A O   1 
ATOM   776  C  CB  . LYS A 1 124 ? -19.342 -25.015 -42.854 1.00 46.36  ? 387  LYS A CB  1 
ATOM   777  C  CG  . LYS A 1 124 ? -18.176 -24.136 -43.272 1.00 52.24  ? 387  LYS A CG  1 
ATOM   778  C  CD  . LYS A 1 124 ? -17.214 -24.919 -44.124 1.00 56.76  ? 387  LYS A CD  1 
ATOM   779  C  CE  . LYS A 1 124 ? -15.868 -24.277 -44.340 1.00 60.81  ? 387  LYS A CE  1 
ATOM   780  N  NZ  . LYS A 1 124 ? -14.995 -25.245 -45.062 1.00 67.63  ? 387  LYS A NZ  1 
ATOM   781  N  N   . LYS A 1 125 ? -21.898 -26.216 -41.349 1.00 37.23  ? 388  LYS A N   1 
ATOM   782  C  CA  . LYS A 1 125 ? -23.058 -27.124 -41.500 1.00 37.87  ? 388  LYS A CA  1 
ATOM   783  C  C   . LYS A 1 125 ? -23.940 -27.114 -40.248 1.00 32.36  ? 388  LYS A C   1 
ATOM   784  O  O   . LYS A 1 125 ? -24.721 -28.024 -40.083 1.00 36.36  ? 388  LYS A O   1 
ATOM   785  C  CB  . LYS A 1 125 ? -22.559 -28.511 -41.867 1.00 37.72  ? 388  LYS A CB  1 
ATOM   786  C  CG  . LYS A 1 125 ? -21.983 -28.621 -43.272 1.00 45.50  ? 388  LYS A CG  1 
ATOM   787  C  CD  . LYS A 1 125 ? -21.766 -30.092 -43.681 1.00 57.84  ? 388  LYS A CD  1 
ATOM   788  C  CE  . LYS A 1 125 ? -20.578 -30.756 -43.008 1.00 60.97  ? 388  LYS A CE  1 
ATOM   789  N  NZ  . LYS A 1 125 ? -20.525 -32.223 -43.235 1.00 68.77  ? 388  LYS A NZ  1 
ATOM   790  N  N   . LYS A 1 126 ? -23.805 -26.125 -39.380 1.00 34.46  ? 389  LYS A N   1 
ATOM   791  C  CA  . LYS A 1 126 ? -24.564 -26.091 -38.110 1.00 33.72  ? 389  LYS A CA  1 
ATOM   792  C  C   . LYS A 1 126 ? -25.082 -24.676 -37.910 1.00 38.00  ? 389  LYS A C   1 
ATOM   793  O  O   . LYS A 1 126 ? -24.466 -23.768 -38.451 1.00 39.32  ? 389  LYS A O   1 
ATOM   794  C  CB  . LYS A 1 126 ? -23.698 -26.435 -36.891 1.00 36.10  ? 389  LYS A CB  1 
ATOM   795  C  CG  . LYS A 1 126 ? -23.125 -27.841 -36.914 1.00 31.95  ? 389  LYS A CG  1 
ATOM   796  C  CD  . LYS A 1 126 ? -24.167 -28.851 -36.550 1.00 33.36  ? 389  LYS A CD  1 
ATOM   797  C  CE  . LYS A 1 126 ? -23.537 -30.223 -36.524 1.00 35.95  ? 389  LYS A CE  1 
ATOM   798  N  NZ  . LYS A 1 126 ? -24.543 -31.295 -36.445 1.00 35.48  ? 389  LYS A NZ  1 
ATOM   799  N  N   . THR A 1 127 ? -26.140 -24.513 -37.111 1.00 33.19  ? 390  THR A N   1 
ATOM   800  C  CA  . THR A 1 127 ? -26.730 -23.183 -36.798 1.00 32.96  ? 390  THR A CA  1 
ATOM   801  C  C   . THR A 1 127 ? -26.845 -23.045 -35.302 1.00 31.33  ? 390  THR A C   1 
ATOM   802  O  O   . THR A 1 127 ? -27.614 -23.757 -34.677 1.00 35.66  ? 390  THR A O   1 
ATOM   803  C  CB  . THR A 1 127 ? -28.156 -23.009 -37.358 1.00 36.82  ? 390  THR A CB  1 
ATOM   804  O  OG1 . THR A 1 127 ? -28.000 -23.185 -38.766 1.00 36.53  ? 390  THR A OG1 1 
ATOM   805  C  CG2 . THR A 1 127 ? -28.747 -21.681 -36.943 1.00 38.52  ? 390  THR A CG2 1 
ATOM   806  N  N   . PRO A 1 128 ? -26.092 -22.131 -34.682 1.00 29.45  ? 391  PRO A N   1 
ATOM   807  C  CA  . PRO A 1 128 ? -26.232 -21.912 -33.251 1.00 34.35  ? 391  PRO A CA  1 
ATOM   808  C  C   . PRO A 1 128 ? -27.690 -21.531 -32.944 1.00 34.46  ? 391  PRO A C   1 
ATOM   809  O  O   . PRO A 1 128 ? -28.317 -20.837 -33.771 1.00 34.28  ? 391  PRO A O   1 
ATOM   810  C  CB  . PRO A 1 128 ? -25.278 -20.746 -32.943 1.00 30.12  ? 391  PRO A CB  1 
ATOM   811  C  CG  . PRO A 1 128 ? -24.379 -20.655 -34.154 1.00 33.01  ? 391  PRO A CG  1 
ATOM   812  C  CD  . PRO A 1 128 ? -25.113 -21.237 -35.328 1.00 32.52  ? 391  PRO A CD  1 
ATOM   813  N  N   . ARG A 1 129 ? -28.151 -21.909 -31.757 1.00 35.09  ? 392  ARG A N   1 
ATOM   814  C  CA  . ARG A 1 129 ? -29.541 -21.708 -31.314 1.00 35.99  ? 392  ARG A CA  1 
ATOM   815  C  C   . ARG A 1 129 ? -29.654 -21.952 -29.804 1.00 47.63  ? 392  ARG A C   1 
ATOM   816  O  O   . ARG A 1 129 ? -28.875 -22.767 -29.251 1.00 38.91  ? 392  ARG A O   1 
ATOM   817  C  CB  . ARG A 1 129 ? -30.462 -22.579 -32.169 1.00 34.75  ? 392  ARG A CB  1 
ATOM   818  C  CG  . ARG A 1 129 ? -30.266 -24.089 -32.098 1.00 35.88  ? 392  ARG A CG  1 
ATOM   819  C  CD  . ARG A 1 129 ? -31.067 -24.731 -30.988 1.00 39.75  ? 392  ARG A CD  1 
ATOM   820  N  NE  . ARG A 1 129 ? -30.811 -26.154 -30.810 1.00 36.27  ? 392  ARG A NE  1 
ATOM   821  C  CZ  . ARG A 1 129 ? -31.437 -26.907 -29.919 1.00 36.57  ? 392  ARG A CZ  1 
ATOM   822  N  NH1 . ARG A 1 129 ? -32.385 -26.386 -29.172 1.00 33.38  ? 392  ARG A NH1 1 
ATOM   823  N  NH2 . ARG A 1 129 ? -31.156 -28.183 -29.781 1.00 35.03  ? 392  ARG A NH2 1 
ATOM   824  N  N   . MET A 1 130 ? -30.646 -21.310 -29.162 1.00 40.47  ? 393  MET A N   1 
ATOM   825  C  CA  . MET A 1 130 ? -30.972 -21.512 -27.739 1.00 42.99  ? 393  MET A CA  1 
ATOM   826  C  C   . MET A 1 130 ? -31.612 -22.867 -27.537 1.00 40.21  ? 393  MET A C   1 
ATOM   827  O  O   . MET A 1 130 ? -32.350 -23.328 -28.417 1.00 41.05  ? 393  MET A O   1 
ATOM   828  C  CB  . MET A 1 130 ? -31.896 -20.407 -27.236 1.00 47.61  ? 393  MET A CB  1 
ATOM   829  C  CG  . MET A 1 130 ? -31.177 -19.081 -27.250 1.00 53.46  ? 393  MET A CG  1 
ATOM   830  S  SD  . MET A 1 130 ? -32.058 -17.769 -26.383 1.00 61.58  ? 393  MET A SD  1 
ATOM   831  C  CE  . MET A 1 130 ? -33.171 -17.320 -27.714 1.00 64.24  ? 393  MET A CE  1 
ATOM   832  N  N   . CYS A 1 131 ? -31.262 -23.512 -26.431 1.00 39.48  ? 394  CYS A N   1 
ATOM   833  C  CA  . CYS A 1 131 ? -31.924 -24.733 -25.942 1.00 41.74  ? 394  CYS A CA  1 
ATOM   834  C  C   . CYS A 1 131 ? -33.126 -24.254 -25.111 1.00 44.67  ? 394  CYS A C   1 
ATOM   835  O  O   . CYS A 1 131 ? -33.104 -23.131 -24.625 1.00 43.35  ? 394  CYS A O   1 
ATOM   836  C  CB  . CYS A 1 131 ? -30.933 -25.627 -25.232 1.00 41.45  ? 394  CYS A CB  1 
ATOM   837  S  SG  . CYS A 1 131 ? -29.808 -26.418 -26.401 1.00 40.28  ? 394  CYS A SG  1 
ATOM   838  N  N   . THR A 1 132 ? -34.155 -25.085 -24.945 0.50 45.91  ? 395  THR A N   1 
ATOM   839  C  CA  . THR A 1 132 ? -35.460 -24.649 -24.371 0.50 46.56  ? 395  THR A CA  1 
ATOM   840  C  C   . THR A 1 132 ? -35.714 -25.330 -23.026 0.50 46.51  ? 395  THR A C   1 
ATOM   841  O  O   . THR A 1 132 ? -35.285 -26.494 -22.851 0.50 47.04  ? 395  THR A O   1 
ATOM   842  C  CB  . THR A 1 132 ? -36.607 -24.929 -25.346 0.50 45.11  ? 395  THR A CB  1 
ATOM   843  O  OG1 . THR A 1 132 ? -36.725 -26.346 -25.463 0.50 49.53  ? 395  THR A OG1 1 
ATOM   844  C  CG2 . THR A 1 132 ? -36.385 -24.313 -26.710 0.50 46.07  ? 395  THR A CG2 1 
ATOM   845  N  N   . ARG A 1 133 ? -36.394 -24.619 -22.119 0.50 51.14  ? 396  ARG A N   1 
ATOM   846  C  CA  . ARG A 1 133 ? -36.938 -25.175 -20.850 0.50 51.35  ? 396  ARG A CA  1 
ATOM   847  C  C   . ARG A 1 133 ? -37.541 -26.548 -21.165 0.50 52.31  ? 396  ARG A C   1 
ATOM   848  O  O   . ARG A 1 133 ? -37.187 -27.546 -20.484 0.50 50.82  ? 396  ARG A O   1 
ATOM   849  C  CB  . ARG A 1 133 ? -37.962 -24.205 -20.247 0.50 54.46  ? 396  ARG A CB  1 
ATOM   850  C  CG  . ARG A 1 133 ? -37.525 -22.748 -20.300 0.50 56.26  ? 396  ARG A CG  1 
ATOM   851  C  CD  . ARG A 1 133 ? -38.293 -21.792 -19.403 0.50 59.47  ? 396  ARG A CD  1 
ATOM   852  N  NE  . ARG A 1 133 ? -37.764 -20.434 -19.515 0.50 63.11  ? 396  ARG A NE  1 
ATOM   853  C  CZ  . ARG A 1 133 ? -37.983 -19.451 -18.644 0.50 67.18  ? 396  ARG A CZ  1 
ATOM   854  N  NH1 . ARG A 1 133 ? -38.741 -19.660 -17.581 0.50 71.05  ? 396  ARG A NH1 1 
ATOM   855  N  NH2 . ARG A 1 133 ? -37.444 -18.260 -18.841 0.50 66.78  ? 396  ARG A NH2 1 
ATOM   856  N  N   . GLU A 1 134 ? -38.382 -26.600 -22.200 0.50 53.88  ? 397  GLU A N   1 
ATOM   857  C  CA  . GLU A 1 134 ? -39.017 -27.845 -22.700 0.50 55.72  ? 397  GLU A CA  1 
ATOM   858  C  C   . GLU A 1 134 ? -37.938 -28.911 -22.920 0.50 56.31  ? 397  GLU A C   1 
ATOM   859  O  O   . GLU A 1 134 ? -38.245 -30.107 -22.753 0.50 55.40  ? 397  GLU A O   1 
ATOM   860  C  CB  . GLU A 1 134 ? -39.783 -27.550 -23.991 0.50 56.70  ? 397  GLU A CB  1 
ATOM   861  C  CG  . GLU A 1 134 ? -40.990 -26.645 -23.796 0.50 55.85  ? 397  GLU A CG  1 
ATOM   862  C  CD  . GLU A 1 134 ? -40.702 -25.181 -23.497 0.50 56.89  ? 397  GLU A CD  1 
ATOM   863  O  OE1 . GLU A 1 134 ? -39.681 -24.647 -23.991 0.50 45.43  ? 397  GLU A OE1 1 
ATOM   864  O  OE2 . GLU A 1 134 ? -41.525 -24.563 -22.778 0.50 60.73  ? 397  GLU A OE2 1 
ATOM   865  N  N   . GLU A 1 135 ? -36.730 -28.493 -23.318 0.50 58.71  ? 398  GLU A N   1 
ATOM   866  C  CA  . GLU A 1 135 ? -35.554 -29.390 -23.490 0.50 57.92  ? 398  GLU A CA  1 
ATOM   867  C  C   . GLU A 1 135 ? -34.902 -29.623 -22.126 0.50 58.55  ? 398  GLU A C   1 
ATOM   868  O  O   . GLU A 1 135 ? -34.526 -30.772 -21.837 0.50 55.49  ? 398  GLU A O   1 
ATOM   869  C  CB  . GLU A 1 135 ? -34.522 -28.787 -24.443 0.50 55.38  ? 398  GLU A CB  1 
ATOM   870  C  CG  . GLU A 1 135 ? -34.854 -28.968 -25.910 0.50 53.83  ? 398  GLU A CG  1 
ATOM   871  C  CD  . GLU A 1 135 ? -33.919 -28.193 -26.820 0.50 51.72  ? 398  GLU A CD  1 
ATOM   872  O  OE1 . GLU A 1 135 ? -33.711 -26.994 -26.556 0.50 44.67  ? 398  GLU A OE1 1 
ATOM   873  O  OE2 . GLU A 1 135 ? -33.378 -28.796 -27.771 0.50 55.31  ? 398  GLU A OE2 1 
ATOM   874  N  N   . PHE A 1 136 ? -34.766 -28.560 -21.330 0.50 60.45  ? 399  PHE A N   1 
ATOM   875  C  CA  . PHE A 1 136 ? -34.098 -28.591 -20.005 0.50 65.96  ? 399  PHE A CA  1 
ATOM   876  C  C   . PHE A 1 136 ? -34.851 -29.554 -19.079 0.50 68.31  ? 399  PHE A C   1 
ATOM   877  O  O   . PHE A 1 136 ? -34.203 -30.424 -18.460 0.50 67.24  ? 399  PHE A O   1 
ATOM   878  C  CB  . PHE A 1 136 ? -33.997 -27.182 -19.419 0.50 65.05  ? 399  PHE A CB  1 
ATOM   879  C  CG  . PHE A 1 136 ? -33.077 -27.091 -18.229 0.50 65.77  ? 399  PHE A CG  1 
ATOM   880  C  CD1 . PHE A 1 136 ? -31.728 -27.381 -18.358 0.50 64.58  ? 399  PHE A CD1 1 
ATOM   881  C  CD2 . PHE A 1 136 ? -33.561 -26.739 -16.981 0.50 65.14  ? 399  PHE A CD2 1 
ATOM   882  C  CE1 . PHE A 1 136 ? -30.879 -27.304 -17.267 0.50 63.72  ? 399  PHE A CE1 1 
ATOM   883  C  CE2 . PHE A 1 136 ? -32.710 -26.662 -15.891 0.50 65.53  ? 399  PHE A CE2 1 
ATOM   884  C  CZ  . PHE A 1 136 ? -31.371 -26.944 -16.037 0.50 66.22  ? 399  PHE A CZ  1 
ATOM   885  N  N   . THR A 1 137 ? -36.177 -29.408 -18.998 0.50 72.17  ? 400  THR A N   1 
ATOM   886  C  CA  . THR A 1 137 ? -37.071 -30.280 -18.190 0.50 75.88  ? 400  THR A CA  1 
ATOM   887  C  C   . THR A 1 137 ? -36.889 -31.729 -18.653 0.50 78.59  ? 400  THR A C   1 
ATOM   888  O  O   . THR A 1 137 ? -36.604 -32.588 -17.802 0.50 79.64  ? 400  THR A O   1 
ATOM   889  C  CB  . THR A 1 137 ? -38.529 -29.813 -18.283 0.50 74.37  ? 400  THR A CB  1 
ATOM   890  O  OG1 . THR A 1 137 ? -38.537 -28.417 -17.988 0.50 75.99  ? 400  THR A OG1 1 
ATOM   891  C  CG2 . THR A 1 137 ? -39.458 -30.546 -17.340 0.50 74.25  ? 400  THR A CG2 1 
ATOM   892  N  N   . ARG A 1 138 ? -37.023 -31.980 -19.957 0.50 84.83  ? 401  ARG A N   1 
ATOM   893  C  CA  . ARG A 1 138 ? -36.940 -33.345 -20.541 0.50 91.38  ? 401  ARG A CA  1 
ATOM   894  C  C   . ARG A 1 138 ? -35.746 -34.070 -19.909 0.50 93.45  ? 401  ARG A C   1 
ATOM   895  O  O   . ARG A 1 138 ? -35.943 -35.179 -19.375 0.50 94.06  ? 401  ARG A O   1 
ATOM   896  C  CB  . ARG A 1 138 ? -36.836 -33.273 -22.068 0.50 97.99  ? 401  ARG A CB  1 
ATOM   897  C  CG  . ARG A 1 138 ? -37.429 -34.478 -22.785 0.50 102.35 ? 401  ARG A CG  1 
ATOM   898  C  CD  . ARG A 1 138 ? -37.856 -34.160 -24.206 0.50 104.03 ? 401  ARG A CD  1 
ATOM   899  N  NE  . ARG A 1 138 ? -36.734 -33.781 -25.053 0.50 108.71 ? 401  ARG A NE  1 
ATOM   900  C  CZ  . ARG A 1 138 ? -36.084 -34.611 -25.862 0.50 111.04 ? 401  ARG A CZ  1 
ATOM   901  N  NH1 . ARG A 1 138 ? -36.447 -35.881 -25.941 0.50 110.79 ? 401  ARG A NH1 1 
ATOM   902  N  NH2 . ARG A 1 138 ? -35.075 -34.168 -26.592 0.50 111.86 ? 401  ARG A NH2 1 
ATOM   903  N  N   . LYS A 1 139 ? -34.560 -33.457 -19.954 0.50 94.08  ? 402  LYS A N   1 
ATOM   904  C  CA  . LYS A 1 139 ? -33.328 -34.005 -19.331 0.50 98.08  ? 402  LYS A CA  1 
ATOM   905  C  C   . LYS A 1 139 ? -33.626 -34.316 -17.860 0.50 99.54  ? 402  LYS A C   1 
ATOM   906  O  O   . LYS A 1 139 ? -33.315 -35.439 -17.416 0.50 99.24  ? 402  LYS A O   1 
ATOM   907  C  CB  . LYS A 1 139 ? -32.164 -33.018 -19.463 0.50 99.21  ? 402  LYS A CB  1 
ATOM   908  C  CG  . LYS A 1 139 ? -31.940 -32.466 -20.864 0.50 100.94 ? 402  LYS A CG  1 
ATOM   909  C  CD  . LYS A 1 139 ? -30.637 -31.704 -21.021 0.50 101.43 ? 402  LYS A CD  1 
ATOM   910  C  CE  . LYS A 1 139 ? -29.419 -32.602 -21.074 0.50 101.49 ? 402  LYS A CE  1 
ATOM   911  N  NZ  . LYS A 1 139 ? -29.456 -33.507 -22.248 0.50 101.11 ? 402  LYS A NZ  1 
ATOM   912  N  N   . VAL A 1 140 ? -34.225 -33.355 -17.150 0.50 102.16 ? 403  VAL A N   1 
ATOM   913  C  CA  . VAL A 1 140 ? -34.523 -33.435 -15.688 0.50 108.08 ? 403  VAL A CA  1 
ATOM   914  C  C   . VAL A 1 140 ? -35.536 -34.561 -15.442 0.50 114.99 ? 403  VAL A C   1 
ATOM   915  O  O   . VAL A 1 140 ? -35.399 -35.254 -14.414 0.50 122.08 ? 403  VAL A O   1 
ATOM   916  C  CB  . VAL A 1 140 ? -35.030 -32.086 -15.140 0.50 107.01 ? 403  VAL A CB  1 
ATOM   917  C  CG1 . VAL A 1 140 ? -35.447 -32.190 -13.681 0.50 106.34 ? 403  VAL A CG1 1 
ATOM   918  C  CG2 . VAL A 1 140 ? -34.002 -30.980 -15.323 0.50 105.68 ? 403  VAL A CG2 1 
ATOM   919  N  N   . ARG A 1 141 ? -36.508 -34.733 -16.344 0.50 119.02 ? 404  ARG A N   1 
ATOM   920  C  CA  . ARG A 1 141 ? -37.541 -35.803 -16.267 0.50 118.83 ? 404  ARG A CA  1 
ATOM   921  C  C   . ARG A 1 141 ? -36.838 -37.164 -16.251 0.50 120.35 ? 404  ARG A C   1 
ATOM   922  O  O   . ARG A 1 141 ? -37.201 -38.005 -15.407 0.50 123.59 ? 404  ARG A O   1 
ATOM   923  C  CB  . ARG A 1 141 ? -38.523 -35.693 -17.436 0.50 120.32 ? 404  ARG A CB  1 
ATOM   924  C  CG  . ARG A 1 141 ? -39.450 -34.489 -17.353 0.50 125.38 ? 404  ARG A CG  1 
ATOM   925  C  CD  . ARG A 1 141 ? -40.561 -34.666 -16.333 0.50 129.99 ? 404  ARG A CD  1 
ATOM   926  N  NE  . ARG A 1 141 ? -41.607 -33.662 -16.487 0.50 133.26 ? 404  ARG A NE  1 
ATOM   927  C  CZ  . ARG A 1 141 ? -41.805 -32.640 -15.660 0.50 132.21 ? 404  ARG A CZ  1 
ATOM   928  N  NH1 . ARG A 1 141 ? -41.031 -32.484 -14.600 0.50 132.25 ? 404  ARG A NH1 1 
ATOM   929  N  NH2 . ARG A 1 141 ? -42.782 -31.780 -15.895 0.50 130.74 ? 404  ARG A NH2 1 
ATOM   930  N  N   . SER A 1 142 ? -35.875 -37.364 -17.156 0.50 122.15 ? 405  SER A N   1 
ATOM   931  C  CA  . SER A 1 142 ? -34.886 -38.472 -17.111 0.50 124.18 ? 405  SER A CA  1 
ATOM   932  C  C   . SER A 1 142 ? -33.817 -38.113 -16.070 0.50 124.25 ? 405  SER A C   1 
ATOM   933  O  O   . SER A 1 142 ? -34.115 -37.263 -15.210 0.50 126.68 ? 405  SER A O   1 
ATOM   934  C  CB  . SER A 1 142 ? -34.298 -38.735 -18.474 0.50 127.35 ? 405  SER A CB  1 
ATOM   935  O  OG  . SER A 1 142 ? -33.603 -37.593 -18.953 0.50 128.60 ? 405  SER A OG  1 
ATOM   936  N  N   . ASN A 1 143 ? -32.628 -38.721 -16.135 0.50 122.30 ? 406  ASN A N   1 
ATOM   937  C  CA  . ASN A 1 143 ? -31.548 -38.502 -15.132 0.50 123.29 ? 406  ASN A CA  1 
ATOM   938  C  C   . ASN A 1 143 ? -30.209 -38.248 -15.833 0.50 123.21 ? 406  ASN A C   1 
ATOM   939  O  O   . ASN A 1 143 ? -29.417 -39.204 -15.958 0.50 125.49 ? 406  ASN A O   1 
ATOM   940  C  CB  . ASN A 1 143 ? -31.428 -39.674 -14.155 0.50 122.84 ? 406  ASN A CB  1 
ATOM   941  C  CG  . ASN A 1 143 ? -32.445 -39.613 -13.036 0.50 122.80 ? 406  ASN A CG  1 
ATOM   942  O  OD1 . ASN A 1 143 ? -33.147 -38.615 -12.880 0.50 120.59 ? 406  ASN A OD1 1 
ATOM   943  N  ND2 . ASN A 1 143 ? -32.529 -40.673 -12.250 0.50 124.83 ? 406  ASN A ND2 1 
ATOM   944  N  N   . ALA A 1 144 ? -29.966 -36.999 -16.243 0.50 122.45 ? 407  ALA A N   1 
ATOM   945  C  CA  . ALA A 1 144 ? -28.685 -36.517 -16.812 0.50 122.34 ? 407  ALA A CA  1 
ATOM   946  C  C   . ALA A 1 144 ? -28.036 -35.532 -15.833 0.50 123.84 ? 407  ALA A C   1 
ATOM   947  O  O   . ALA A 1 144 ? -28.548 -34.400 -15.711 0.50 127.06 ? 407  ALA A O   1 
ATOM   948  C  CB  . ALA A 1 144 ? -28.925 -35.876 -18.157 0.50 119.87 ? 407  ALA A CB  1 
ATOM   949  N  N   . ALA A 1 145 ? -26.956 -35.948 -15.164 0.50 122.23 ? 408  ALA A N   1 
ATOM   950  C  CA  . ALA A 1 145 ? -26.187 -35.119 -14.207 0.50 120.39 ? 408  ALA A CA  1 
ATOM   951  C  C   . ALA A 1 145 ? -26.172 -33.668 -14.707 0.50 120.92 ? 408  ALA A C   1 
ATOM   952  O  O   . ALA A 1 145 ? -25.657 -33.428 -15.818 0.50 120.64 ? 408  ALA A O   1 
ATOM   953  C  CB  . ALA A 1 145 ? -24.791 -35.672 -14.043 0.50 118.71 ? 408  ALA A CB  1 
ATOM   954  N  N   . LEU A 1 146 ? -26.736 -32.747 -13.918 0.50 120.45 ? 409  LEU A N   1 
ATOM   955  C  CA  . LEU A 1 146 ? -26.869 -31.304 -14.260 0.50 116.10 ? 409  LEU A CA  1 
ATOM   956  C  C   . LEU A 1 146 ? -25.970 -30.473 -13.338 0.50 112.66 ? 409  LEU A C   1 
ATOM   957  O  O   . LEU A 1 146 ? -26.086 -29.230 -13.364 0.50 112.09 ? 409  LEU A O   1 
ATOM   958  C  CB  . LEU A 1 146 ? -28.337 -30.892 -14.113 0.50 114.27 ? 409  LEU A CB  1 
ATOM   959  C  CG  . LEU A 1 146 ? -29.311 -31.590 -15.060 0.50 113.05 ? 409  LEU A CG  1 
ATOM   960  C  CD1 . LEU A 1 146 ? -30.750 -31.318 -14.652 0.50 112.57 ? 409  LEU A CD1 1 
ATOM   961  C  CD2 . LEU A 1 146 ? -29.073 -31.160 -16.501 0.50 110.94 ? 409  LEU A CD2 1 
ATOM   962  N  N   . GLY A 1 147 ? -25.111 -31.140 -12.561 0.50 107.64 ? 410  GLY A N   1 
ATOM   963  C  CA  . GLY A 1 147 ? -24.226 -30.506 -11.566 0.50 105.81 ? 410  GLY A CA  1 
ATOM   964  C  C   . GLY A 1 147 ? -24.963 -29.451 -10.756 0.50 105.26 ? 410  GLY A C   1 
ATOM   965  O  O   . GLY A 1 147 ? -24.384 -28.369 -10.532 0.50 100.44 ? 410  GLY A O   1 
ATOM   966  N  N   . ALA A 1 148 ? -26.196 -29.755 -10.336 0.50 105.14 ? 411  ALA A N   1 
ATOM   967  C  CA  . ALA A 1 148 ? -27.066 -28.873 -9.523  0.50 105.70 ? 411  ALA A CA  1 
ATOM   968  C  C   . ALA A 1 148 ? -26.705 -29.024 -8.040  0.50 108.59 ? 411  ALA A C   1 
ATOM   969  O  O   . ALA A 1 148 ? -25.799 -29.824 -7.731  0.50 107.40 ? 411  ALA A O   1 
ATOM   970  C  CB  . ALA A 1 148 ? -28.516 -29.206 -9.778  0.50 103.61 ? 411  ALA A CB  1 
ATOM   971  N  N   . ILE A 1 149 ? -27.390 -28.279 -7.164  0.50 112.26 ? 412  ILE A N   1 
ATOM   972  C  CA  . ILE A 1 149 ? -27.178 -28.285 -5.684  0.50 112.48 ? 412  ILE A CA  1 
ATOM   973  C  C   . ILE A 1 149 ? -28.545 -28.281 -4.988  0.50 112.38 ? 412  ILE A C   1 
ATOM   974  O  O   . ILE A 1 149 ? -29.138 -27.187 -4.899  0.50 112.66 ? 412  ILE A O   1 
ATOM   975  C  CB  . ILE A 1 149 ? -26.307 -27.089 -5.251  0.50 113.06 ? 412  ILE A CB  1 
ATOM   976  C  CG1 . ILE A 1 149 ? -27.029 -25.754 -5.453  0.50 113.29 ? 412  ILE A CG1 1 
ATOM   977  C  CG2 . ILE A 1 149 ? -24.963 -27.116 -5.964  0.50 113.90 ? 412  ILE A CG2 1 
ATOM   978  C  CD1 . ILE A 1 149 ? -28.168 -25.516 -4.488  0.50 114.59 ? 412  ILE A CD1 1 
ATOM   979  N  N   . TRP A 1 156 ? -37.281 -26.660 -2.884  0.50 78.33  ? 419  TRP A N   1 
ATOM   980  C  CA  . TRP A 1 156 ? -37.555 -28.073 -3.256  0.50 79.77  ? 419  TRP A CA  1 
ATOM   981  C  C   . TRP A 1 156 ? -36.291 -28.911 -3.065  0.50 86.23  ? 419  TRP A C   1 
ATOM   982  O  O   . TRP A 1 156 ? -35.206 -28.316 -2.908  0.50 85.36  ? 419  TRP A O   1 
ATOM   983  C  CB  . TRP A 1 156 ? -38.056 -28.165 -4.702  0.50 78.79  ? 419  TRP A CB  1 
ATOM   984  C  CG  . TRP A 1 156 ? -38.725 -26.928 -5.220  0.50 75.88  ? 419  TRP A CG  1 
ATOM   985  C  CD1 . TRP A 1 156 ? -40.064 -26.725 -5.387  0.50 74.72  ? 419  TRP A CD1 1 
ATOM   986  C  CD2 . TRP A 1 156 ? -38.082 -25.714 -5.647  0.50 72.78  ? 419  TRP A CD2 1 
ATOM   987  N  NE1 . TRP A 1 156 ? -40.297 -25.469 -5.881  0.50 75.79  ? 419  TRP A NE1 1 
ATOM   988  C  CE2 . TRP A 1 156 ? -39.101 -24.825 -6.048  0.50 72.19  ? 419  TRP A CE2 1 
ATOM   989  C  CE3 . TRP A 1 156 ? -36.751 -25.288 -5.721  0.50 70.52  ? 419  TRP A CE3 1 
ATOM   990  C  CZ2 . TRP A 1 156 ? -38.826 -23.544 -6.521  0.50 69.74  ? 419  TRP A CZ2 1 
ATOM   991  C  CZ3 . TRP A 1 156 ? -36.481 -24.020 -6.184  0.50 67.46  ? 419  TRP A CZ3 1 
ATOM   992  C  CH2 . TRP A 1 156 ? -37.506 -23.162 -6.579  0.50 69.32  ? 419  TRP A CH2 1 
ATOM   993  N  N   . LYS A 1 157 ? -36.419 -30.238 -3.076  0.50 94.43  ? 420  LYS A N   1 
ATOM   994  C  CA  . LYS A 1 157 ? -35.243 -31.104 -2.789  0.50 99.95  ? 420  LYS A CA  1 
ATOM   995  C  C   . LYS A 1 157 ? -34.811 -31.803 -4.075  0.50 103.17 ? 420  LYS A C   1 
ATOM   996  O  O   . LYS A 1 157 ? -33.609 -32.063 -4.232  0.50 108.89 ? 420  LYS A O   1 
ATOM   997  C  CB  . LYS A 1 157 ? -35.585 -32.107 -1.682  0.50 101.48 ? 420  LYS A CB  1 
ATOM   998  C  CG  . LYS A 1 157 ? -35.379 -33.573 -2.041  0.50 104.23 ? 420  LYS A CG  1 
ATOM   999  C  CD  . LYS A 1 157 ? -36.577 -34.204 -2.719  0.50 105.61 ? 420  LYS A CD  1 
ATOM   1000 C  CE  . LYS A 1 157 ? -37.779 -34.302 -1.804  0.50 105.51 ? 420  LYS A CE  1 
ATOM   1001 N  NZ  . LYS A 1 157 ? -38.920 -34.979 -2.464  0.50 105.61 ? 420  LYS A NZ  1 
ATOM   1002 N  N   . SER A 1 158 ? -35.771 -32.107 -4.941  0.50 102.73 ? 421  SER A N   1 
ATOM   1003 C  CA  . SER A 1 158 ? -35.409 -32.708 -6.247  0.50 99.60  ? 421  SER A CA  1 
ATOM   1004 C  C   . SER A 1 158 ? -35.486 -31.634 -7.335  0.50 96.74  ? 421  SER A C   1 
ATOM   1005 O  O   . SER A 1 158 ? -36.351 -30.744 -7.228  0.50 91.25  ? 421  SER A O   1 
ATOM   1006 C  CB  . SER A 1 158 ? -36.280 -33.886 -6.555  0.50 100.67 ? 421  SER A CB  1 
ATOM   1007 O  OG  . SER A 1 158 ? -36.036 -34.364 -7.869  0.50 103.81 ? 421  SER A OG  1 
ATOM   1008 N  N   . ALA A 1 159 ? -34.593 -31.705 -8.322  0.50 93.90  ? 422  ALA A N   1 
ATOM   1009 C  CA  . ALA A 1 159 ? -34.625 -30.745 -9.446  0.50 88.65  ? 422  ALA A CA  1 
ATOM   1010 C  C   . ALA A 1 159 ? -35.928 -30.947 -10.225 0.50 84.39  ? 422  ALA A C   1 
ATOM   1011 O  O   . ALA A 1 159 ? -36.413 -29.977 -10.826 0.50 79.81  ? 422  ALA A O   1 
ATOM   1012 C  CB  . ALA A 1 159 ? -33.407 -30.936 -10.305 0.50 90.52  ? 422  ALA A CB  1 
ATOM   1013 N  N   . ARG A 1 160 ? -36.498 -32.149 -10.151 0.50 80.26  ? 423  ARG A N   1 
ATOM   1014 C  CA  . ARG A 1 160 ? -37.784 -32.419 -10.842 0.50 81.63  ? 423  ARG A CA  1 
ATOM   1015 C  C   . ARG A 1 160 ? -38.893 -31.510 -10.282 0.50 83.86  ? 423  ARG A C   1 
ATOM   1016 O  O   . ARG A 1 160 ? -39.919 -31.378 -10.958 0.50 82.57  ? 423  ARG A O   1 
ATOM   1017 C  CB  . ARG A 1 160 ? -38.135 -33.900 -10.702 0.50 82.59  ? 423  ARG A CB  1 
ATOM   1018 C  CG  . ARG A 1 160 ? -37.018 -34.839 -11.134 0.50 85.92  ? 423  ARG A CG  1 
ATOM   1019 C  CD  . ARG A 1 160 ? -37.507 -36.256 -11.365 0.50 85.57  ? 423  ARG A CD  1 
ATOM   1020 N  NE  . ARG A 1 160 ? -36.489 -37.121 -11.946 0.50 85.32  ? 423  ARG A NE  1 
ATOM   1021 C  CZ  . ARG A 1 160 ? -36.721 -38.348 -12.393 0.50 86.38  ? 423  ARG A CZ  1 
ATOM   1022 N  NH1 . ARG A 1 160 ? -35.737 -39.068 -12.905 0.50 83.78  ? 423  ARG A NH1 1 
ATOM   1023 N  NH2 . ARG A 1 160 ? -37.939 -38.852 -12.331 0.50 86.69  ? 423  ARG A NH2 1 
ATOM   1024 N  N   . GLU A 1 161 ? -38.711 -30.931 -9.088  0.50 81.25  ? 424  GLU A N   1 
ATOM   1025 C  CA  . GLU A 1 161 ? -39.785 -30.103 -8.462  0.50 78.46  ? 424  GLU A CA  1 
ATOM   1026 C  C   . GLU A 1 161 ? -39.544 -28.611 -8.716  0.50 71.67  ? 424  GLU A C   1 
ATOM   1027 O  O   . GLU A 1 161 ? -40.488 -27.828 -8.550  0.50 66.31  ? 424  GLU A O   1 
ATOM   1028 C  CB  . GLU A 1 161 ? -39.821 -30.350 -6.957  0.50 81.55  ? 424  GLU A CB  1 
ATOM   1029 C  CG  . GLU A 1 161 ? -39.420 -31.759 -6.564  0.50 83.41  ? 424  GLU A CG  1 
ATOM   1030 C  CD  . GLU A 1 161 ? -39.240 -31.965 -5.070  0.50 83.85  ? 424  GLU A CD  1 
ATOM   1031 O  OE1 . GLU A 1 161 ? -39.356 -30.974 -4.320  0.50 83.00  ? 424  GLU A OE1 1 
ATOM   1032 O  OE2 . GLU A 1 161 ? -38.988 -33.116 -4.658  0.50 78.51  ? 424  GLU A OE2 1 
ATOM   1033 N  N   . ALA A 1 162 ? -38.328 -28.237 -9.092  0.50 67.52  ? 425  ALA A N   1 
ATOM   1034 C  CA  . ALA A 1 162 ? -37.951 -26.830 -9.364  0.50 65.74  ? 425  ALA A CA  1 
ATOM   1035 C  C   . ALA A 1 162 ? -38.565 -26.372 -10.691 0.50 62.06  ? 425  ALA A C   1 
ATOM   1036 O  O   . ALA A 1 162 ? -39.225 -25.312 -10.701 0.50 59.83  ? 425  ALA A O   1 
ATOM   1037 C  CB  . ALA A 1 162 ? -36.447 -26.688 -9.370  0.50 66.19  ? 425  ALA A CB  1 
ATOM   1038 N  N   . VAL A 1 163 ? -38.355 -27.141 -11.764 0.50 60.73  ? 426  VAL A N   1 
ATOM   1039 C  CA  . VAL A 1 163 ? -38.772 -26.783 -13.154 0.50 61.08  ? 426  VAL A CA  1 
ATOM   1040 C  C   . VAL A 1 163 ? -40.302 -26.767 -13.225 0.50 62.71  ? 426  VAL A C   1 
ATOM   1041 O  O   . VAL A 1 163 ? -40.839 -26.043 -14.079 0.50 60.75  ? 426  VAL A O   1 
ATOM   1042 C  CB  . VAL A 1 163 ? -38.179 -27.745 -14.201 0.50 60.22  ? 426  VAL A CB  1 
ATOM   1043 C  CG1 . VAL A 1 163 ? -36.677 -27.559 -14.349 0.50 61.36  ? 426  VAL A CG1 1 
ATOM   1044 C  CG2 . VAL A 1 163 ? -38.514 -29.196 -13.894 0.50 59.15  ? 426  VAL A CG2 1 
ATOM   1045 N  N   . GLU A 1 164 ? -40.950 -27.571 -12.379 0.50 65.75  ? 427  GLU A N   1 
ATOM   1046 C  CA  . GLU A 1 164 ? -42.435 -27.630 -12.349 0.50 68.91  ? 427  GLU A CA  1 
ATOM   1047 C  C   . GLU A 1 164 ? -42.979 -26.415 -11.586 0.50 68.39  ? 427  GLU A C   1 
ATOM   1048 O  O   . GLU A 1 164 ? -44.038 -25.894 -11.987 0.50 67.74  ? 427  GLU A O   1 
ATOM   1049 C  CB  . GLU A 1 164 ? -42.904 -28.932 -11.706 0.50 68.56  ? 427  GLU A CB  1 
ATOM   1050 C  CG  . GLU A 1 164 ? -42.295 -30.178 -12.315 0.50 68.22  ? 427  GLU A CG  1 
ATOM   1051 C  CD  . GLU A 1 164 ? -42.753 -31.461 -11.643 0.50 69.97  ? 427  GLU A CD  1 
ATOM   1052 O  OE1 . GLU A 1 164 ? -43.647 -31.384 -10.778 0.50 70.84  ? 427  GLU A OE1 1 
ATOM   1053 O  OE2 . GLU A 1 164 ? -42.212 -32.533 -11.981 0.50 69.48  ? 427  GLU A OE2 1 
ATOM   1054 N  N   . ASP A 1 165 ? -42.286 -25.973 -10.536 0.50 67.50  ? 428  ASP A N   1 
ATOM   1055 C  CA  . ASP A 1 165 ? -42.729 -24.736 -9.847  0.50 67.96  ? 428  ASP A CA  1 
ATOM   1056 C  C   . ASP A 1 165 ? -42.467 -23.531 -10.750 0.50 67.42  ? 428  ASP A C   1 
ATOM   1057 O  O   . ASP A 1 165 ? -41.299 -23.316 -11.116 0.50 63.06  ? 428  ASP A O   1 
ATOM   1058 C  CB  . ASP A 1 165 ? -42.030 -24.553 -8.501  0.50 66.89  ? 428  ASP A CB  1 
ATOM   1059 C  CG  . ASP A 1 165 ? -42.404 -23.261 -7.797  0.50 67.27  ? 428  ASP A CG  1 
ATOM   1060 O  OD1 . ASP A 1 165 ? -43.510 -22.756 -8.051  0.50 66.50  ? 428  ASP A OD1 1 
ATOM   1061 O  OD2 . ASP A 1 165 ? -41.581 -22.766 -7.006  0.50 68.93  ? 428  ASP A OD2 1 
ATOM   1062 N  N   . SER A 1 166 ? -43.512 -22.766 -11.068 0.50 67.20  ? 429  SER A N   1 
ATOM   1063 C  CA  . SER A 1 166 ? -43.343 -21.521 -11.862 0.50 67.12  ? 429  SER A CA  1 
ATOM   1064 C  C   . SER A 1 166 ? -42.564 -20.482 -11.049 0.50 65.94  ? 429  SER A C   1 
ATOM   1065 O  O   . SER A 1 166 ? -42.211 -19.439 -11.612 0.50 62.18  ? 429  SER A O   1 
ATOM   1066 C  CB  . SER A 1 166 ? -44.682 -21.003 -12.297 0.50 69.60  ? 429  SER A CB  1 
ATOM   1067 O  OG  . SER A 1 166 ? -45.574 -20.936 -11.192 0.50 73.09  ? 429  SER A OG  1 
ATOM   1068 N  N   . GLY A 1 167 ? -42.319 -20.747 -9.761  0.50 68.31  ? 430  GLY A N   1 
ATOM   1069 C  CA  . GLY A 1 167 ? -41.486 -19.827 -8.960  0.50 66.14  ? 430  GLY A CA  1 
ATOM   1070 C  C   . GLY A 1 167 ? -40.040 -19.889 -9.419  0.50 65.52  ? 430  GLY A C   1 
ATOM   1071 O  O   . GLY A 1 167 ? -39.397 -18.832 -9.484  0.50 61.48  ? 430  GLY A O   1 
ATOM   1072 N  N   . PHE A 1 168 ? -39.558 -21.097 -9.727  0.50 66.27  ? 431  PHE A N   1 
ATOM   1073 C  CA  . PHE A 1 168 ? -38.154 -21.282 -10.172 0.50 65.90  ? 431  PHE A CA  1 
ATOM   1074 C  C   . PHE A 1 168 ? -37.902 -20.415 -11.397 0.50 65.84  ? 431  PHE A C   1 
ATOM   1075 O  O   . PHE A 1 168 ? -36.956 -19.610 -11.377 0.50 63.34  ? 431  PHE A O   1 
ATOM   1076 C  CB  . PHE A 1 168 ? -37.909 -22.762 -10.466 0.50 67.64  ? 431  PHE A CB  1 
ATOM   1077 C  CG  . PHE A 1 168 ? -36.685 -23.081 -11.287 0.50 64.99  ? 431  PHE A CG  1 
ATOM   1078 C  CD1 . PHE A 1 168 ? -35.429 -23.132 -10.707 0.50 64.29  ? 431  PHE A CD1 1 
ATOM   1079 C  CD2 . PHE A 1 168 ? -36.798 -23.364 -12.638 0.50 66.29  ? 431  PHE A CD2 1 
ATOM   1080 C  CE1 . PHE A 1 168 ? -34.309 -23.436 -11.465 0.50 64.31  ? 431  PHE A CE1 1 
ATOM   1081 C  CE2 . PHE A 1 168 ? -35.680 -23.669 -13.395 0.50 64.23  ? 431  PHE A CE2 1 
ATOM   1082 C  CZ  . PHE A 1 168 ? -34.437 -23.706 -12.808 0.50 65.16  ? 431  PHE A CZ  1 
ATOM   1083 N  N   . TRP A 1 169 ? -38.753 -20.553 -12.411 0.50 65.79  ? 432  TRP A N   1 
ATOM   1084 C  CA  . TRP A 1 169 ? -38.527 -19.814 -13.676 0.50 62.98  ? 432  TRP A CA  1 
ATOM   1085 C  C   . TRP A 1 169 ? -38.565 -18.303 -13.430 0.50 65.29  ? 432  TRP A C   1 
ATOM   1086 O  O   . TRP A 1 169 ? -37.842 -17.581 -14.121 0.50 58.12  ? 432  TRP A O   1 
ATOM   1087 C  CB  . TRP A 1 169 ? -39.533 -20.286 -14.725 0.50 61.63  ? 432  TRP A CB  1 
ATOM   1088 C  CG  . TRP A 1 169 ? -39.396 -21.756 -14.969 0.50 62.15  ? 432  TRP A CG  1 
ATOM   1089 C  CD1 . TRP A 1 169 ? -40.253 -22.738 -14.572 0.50 61.88  ? 432  TRP A CD1 1 
ATOM   1090 C  CD2 . TRP A 1 169 ? -38.297 -22.420 -15.618 0.50 63.68  ? 432  TRP A CD2 1 
ATOM   1091 N  NE1 . TRP A 1 169 ? -39.777 -23.962 -14.954 0.50 63.57  ? 432  TRP A NE1 1 
ATOM   1092 C  CE2 . TRP A 1 169 ? -38.579 -23.801 -15.595 0.50 61.75  ? 432  TRP A CE2 1 
ATOM   1093 C  CE3 . TRP A 1 169 ? -37.114 -21.987 -16.227 0.50 62.37  ? 432  TRP A CE3 1 
ATOM   1094 C  CZ2 . TRP A 1 169 ? -37.725 -24.746 -16.159 0.50 61.39  ? 432  TRP A CZ2 1 
ATOM   1095 C  CZ3 . TRP A 1 169 ? -36.270 -22.921 -16.782 0.50 61.69  ? 432  TRP A CZ3 1 
ATOM   1096 C  CH2 . TRP A 1 169 ? -36.574 -24.282 -16.750 0.50 61.28  ? 432  TRP A CH2 1 
ATOM   1097 N  N   . GLU A 1 170 ? -39.342 -17.850 -12.448 0.50 68.67  ? 433  GLU A N   1 
ATOM   1098 C  CA  . GLU A 1 170 ? -39.363 -16.403 -12.112 0.50 67.88  ? 433  GLU A CA  1 
ATOM   1099 C  C   . GLU A 1 170 ? -37.959 -15.971 -11.683 0.50 66.29  ? 433  GLU A C   1 
ATOM   1100 O  O   . GLU A 1 170 ? -37.502 -14.906 -12.129 0.50 70.32  ? 433  GLU A O   1 
ATOM   1101 C  CB  . GLU A 1 170 ? -40.377 -16.119 -11.002 0.50 69.14  ? 433  GLU A CB  1 
ATOM   1102 C  CG  . GLU A 1 170 ? -41.800 -16.501 -11.372 0.50 70.13  ? 433  GLU A CG  1 
ATOM   1103 C  CD  . GLU A 1 170 ? -42.815 -16.372 -10.246 0.50 69.74  ? 433  GLU A CD  1 
ATOM   1104 O  OE1 . GLU A 1 170 ? -42.509 -15.689 -9.252  0.50 69.87  ? 433  GLU A OE1 1 
ATOM   1105 O  OE2 . GLU A 1 170 ? -43.905 -16.964 -10.362 0.50 66.86  ? 433  GLU A OE2 1 
ATOM   1106 N  N   . LEU A 1 171 ? -37.299 -16.770 -10.846 0.50 65.60  ? 434  LEU A N   1 
ATOM   1107 C  CA  . LEU A 1 171 ? -35.903 -16.457 -10.461 0.50 63.41  ? 434  LEU A CA  1 
ATOM   1108 C  C   . LEU A 1 171 ? -35.019 -16.547 -11.703 0.50 58.27  ? 434  LEU A C   1 
ATOM   1109 O  O   . LEU A 1 171 ? -34.148 -15.680 -11.872 0.50 55.47  ? 434  LEU A O   1 
ATOM   1110 C  CB  . LEU A 1 171 ? -35.454 -17.487 -9.428  0.50 64.07  ? 434  LEU A CB  1 
ATOM   1111 C  CG  . LEU A 1 171 ? -36.524 -17.933 -8.435  0.50 65.52  ? 434  LEU A CG  1 
ATOM   1112 C  CD1 . LEU A 1 171 ? -36.133 -19.242 -7.769  0.50 65.40  ? 434  LEU A CD1 1 
ATOM   1113 C  CD2 . LEU A 1 171 ? -36.784 -16.856 -7.396  0.50 64.97  ? 434  LEU A CD2 1 
ATOM   1114 N  N   . VAL A 1 172 ? -35.267 -17.559 -12.540 0.50 54.89  ? 435  VAL A N   1 
ATOM   1115 C  CA  . VAL A 1 172 ? -34.483 -17.716 -13.796 0.50 52.13  ? 435  VAL A CA  1 
ATOM   1116 C  C   . VAL A 1 172 ? -34.705 -16.457 -14.629 0.50 50.96  ? 435  VAL A C   1 
ATOM   1117 O  O   . VAL A 1 172 ? -33.732 -15.920 -15.170 0.50 47.53  ? 435  VAL A O   1 
ATOM   1118 C  CB  . VAL A 1 172 ? -34.925 -18.973 -14.570 0.50 52.28  ? 435  VAL A CB  1 
ATOM   1119 C  CG1 . VAL A 1 172 ? -34.150 -19.138 -15.864 0.50 51.77  ? 435  VAL A CG1 1 
ATOM   1120 C  CG2 . VAL A 1 172 ? -34.829 -20.229 -13.719 0.50 50.95  ? 435  VAL A CG2 1 
ATOM   1121 N  N   . ASP A 1 173 ? -35.945 -15.976 -14.654 0.50 54.26  ? 436  ASP A N   1 
ATOM   1122 C  CA  . ASP A 1 173 ? -36.282 -14.779 -15.466 0.50 54.27  ? 436  ASP A CA  1 
ATOM   1123 C  C   . ASP A 1 173 ? -35.472 -13.591 -14.944 0.50 51.94  ? 436  ASP A C   1 
ATOM   1124 O  O   . ASP A 1 173 ? -34.906 -12.860 -15.768 0.50 50.82  ? 436  ASP A O   1 
ATOM   1125 C  CB  . ASP A 1 173 ? -37.792 -14.540 -15.443 0.50 59.04  ? 436  ASP A CB  1 
ATOM   1126 C  CG  . ASP A 1 173 ? -38.569 -15.576 -16.236 0.50 59.89  ? 436  ASP A CG  1 
ATOM   1127 O  OD1 . ASP A 1 173 ? -37.928 -16.349 -16.972 0.50 60.71  ? 436  ASP A OD1 1 
ATOM   1128 O  OD2 . ASP A 1 173 ? -39.804 -15.609 -16.100 0.50 59.95  ? 436  ASP A OD2 1 
ATOM   1129 N  N   . LYS A 1 174 ? -35.420 -13.419 -13.619 0.50 50.35  ? 437  LYS A N   1 
ATOM   1130 C  CA  . LYS A 1 174 ? -34.719 -12.235 -13.061 0.50 49.81  ? 437  LYS A CA  1 
ATOM   1131 C  C   . LYS A 1 174 ? -33.250 -12.266 -13.493 0.50 50.25  ? 437  LYS A C   1 
ATOM   1132 O  O   . LYS A 1 174 ? -32.792 -11.266 -14.063 0.50 45.75  ? 437  LYS A O   1 
ATOM   1133 C  CB  . LYS A 1 174 ? -34.844 -12.184 -11.535 0.50 50.96  ? 437  LYS A CB  1 
ATOM   1134 C  CG  . LYS A 1 174 ? -34.211 -10.952 -10.905 0.50 51.20  ? 437  LYS A CG  1 
ATOM   1135 C  CD  . LYS A 1 174 ? -34.313 -10.903 -9.397  0.50 52.36  ? 437  LYS A CD  1 
ATOM   1136 C  CE  . LYS A 1 174 ? -33.688 -9.653  -8.814  0.50 50.38  ? 437  LYS A CE  1 
ATOM   1137 N  NZ  . LYS A 1 174 ? -33.696 -9.672  -7.333  0.50 52.08  ? 437  LYS A NZ  1 
ATOM   1138 N  N   . GLU A 1 175 ? -32.555 -13.377 -13.236 0.50 51.99  ? 438  GLU A N   1 
ATOM   1139 C  CA  . GLU A 1 175 ? -31.123 -13.498 -13.608 0.50 51.48  ? 438  GLU A CA  1 
ATOM   1140 C  C   . GLU A 1 175 ? -31.015 -13.376 -15.127 0.50 49.86  ? 438  GLU A C   1 
ATOM   1141 O  O   . GLU A 1 175 ? -30.070 -12.726 -15.600 0.50 49.89  ? 438  GLU A O   1 
ATOM   1142 C  CB  . GLU A 1 175 ? -30.586 -14.844 -13.127 0.50 53.82  ? 438  GLU A CB  1 
ATOM   1143 C  CG  . GLU A 1 175 ? -29.142 -15.101 -13.519 0.50 54.60  ? 438  GLU A CG  1 
ATOM   1144 C  CD  . GLU A 1 175 ? -28.101 -14.500 -12.591 0.50 54.90  ? 438  GLU A CD  1 
ATOM   1145 O  OE1 . GLU A 1 175 ? -26.895 -14.748 -12.817 0.50 58.02  ? 438  GLU A OE1 1 
ATOM   1146 O  OE2 . GLU A 1 175 ? -28.498 -13.797 -11.645 0.50 57.71  ? 438  GLU A OE2 1 
ATOM   1147 N  N   . ARG A 1 176 ? -31.956 -13.969 -15.858 0.50 51.60  ? 439  ARG A N   1 
ATOM   1148 C  CA  . ARG A 1 176 ? -31.967 -13.959 -17.343 0.50 51.27  ? 439  ARG A CA  1 
ATOM   1149 C  C   . ARG A 1 176 ? -31.993 -12.501 -17.803 0.50 52.69  ? 439  ARG A C   1 
ATOM   1150 O  O   . ARG A 1 176 ? -31.214 -12.146 -18.707 0.50 55.10  ? 439  ARG A O   1 
ATOM   1151 C  CB  . ARG A 1 176 ? -33.160 -14.751 -17.887 0.50 51.89  ? 439  ARG A CB  1 
ATOM   1152 C  CG  . ARG A 1 176 ? -33.108 -14.992 -19.391 0.50 49.43  ? 439  ARG A CG  1 
ATOM   1153 C  CD  . ARG A 1 176 ? -34.166 -15.976 -19.848 0.50 47.27  ? 439  ARG A CD  1 
ATOM   1154 N  NE  . ARG A 1 176 ? -33.946 -16.444 -21.209 0.50 49.34  ? 439  ARG A NE  1 
ATOM   1155 C  CZ  . ARG A 1 176 ? -34.430 -15.859 -22.306 0.50 47.28  ? 439  ARG A CZ  1 
ATOM   1156 N  NH1 . ARG A 1 176 ? -35.174 -14.770 -22.213 0.50 47.66  ? 439  ARG A NH1 1 
ATOM   1157 N  NH2 . ARG A 1 176 ? -34.179 -16.370 -23.498 0.50 47.91  ? 439  ARG A NH2 1 
ATOM   1158 N  N   . ASN A 1 177 ? -32.845 -11.682 -17.178 0.50 58.55  ? 440  ASN A N   1 
ATOM   1159 C  CA  . ASN A 1 177 ? -33.001 -10.239 -17.505 0.50 59.40  ? 440  ASN A CA  1 
ATOM   1160 C  C   . ASN A 1 177 ? -31.714 -9.501  -17.121 0.50 59.11  ? 440  ASN A C   1 
ATOM   1161 O  O   . ASN A 1 177 ? -31.268 -8.639  -17.905 0.50 60.20  ? 440  ASN A O   1 
ATOM   1162 C  CB  . ASN A 1 177 ? -34.237 -9.637  -16.830 0.50 61.94  ? 440  ASN A CB  1 
ATOM   1163 C  CG  . ASN A 1 177 ? -35.524 -10.096 -17.482 0.50 61.37  ? 440  ASN A CG  1 
ATOM   1164 O  OD1 . ASN A 1 177 ? -35.517 -10.572 -18.617 0.50 61.23  ? 440  ASN A OD1 1 
ATOM   1165 N  ND2 . ASN A 1 177 ? -36.629 -9.969  -16.768 0.50 63.15  ? 440  ASN A ND2 1 
ATOM   1166 N  N   . LEU A 1 178 ? -31.139 -9.844  -15.966 0.50 62.37  ? 441  LEU A N   1 
ATOM   1167 C  CA  . LEU A 1 178 ? -29.851 -9.286  -15.476 0.50 61.41  ? 441  LEU A CA  1 
ATOM   1168 C  C   . LEU A 1 178 ? -28.743 -9.589  -16.492 0.50 61.87  ? 441  LEU A C   1 
ATOM   1169 O  O   . LEU A 1 178 ? -27.970 -8.660  -16.814 0.50 60.99  ? 441  LEU A O   1 
ATOM   1170 C  CB  . LEU A 1 178 ? -29.546 -9.887  -14.102 0.50 64.46  ? 441  LEU A CB  1 
ATOM   1171 C  CG  . LEU A 1 178 ? -30.604 -9.620  -13.031 0.50 66.47  ? 441  LEU A CG  1 
ATOM   1172 C  CD1 . LEU A 1 178 ? -30.132 -10.092 -11.663 0.50 67.08  ? 441  LEU A CD1 1 
ATOM   1173 C  CD2 . LEU A 1 178 ? -30.968 -8.144  -12.984 0.50 66.28  ? 441  LEU A CD2 1 
ATOM   1174 N  N   . HIS A 1 179 ? -28.677 -10.828 -16.994 1.00 61.66  ? 442  HIS A N   1 
ATOM   1175 C  CA  . HIS A 1 179 ? -27.682 -11.227 -18.036 1.00 62.16  ? 442  HIS A CA  1 
ATOM   1176 C  C   . HIS A 1 179 ? -27.809 -10.329 -19.281 1.00 65.74  ? 442  HIS A C   1 
ATOM   1177 O  O   . HIS A 1 179 ? -26.766 -9.839  -19.786 1.00 66.12  ? 442  HIS A O   1 
ATOM   1178 C  CB  . HIS A 1 179 ? -27.776 -12.731 -18.349 1.00 57.70  ? 442  HIS A CB  1 
ATOM   1179 C  CG  . HIS A 1 179 ? -27.191 -13.597 -17.282 1.00 51.25  ? 442  HIS A CG  1 
ATOM   1180 N  ND1 . HIS A 1 179 ? -27.021 -14.957 -17.455 1.00 44.43  ? 442  HIS A ND1 1 
ATOM   1181 C  CD2 . HIS A 1 179 ? -26.733 -13.297 -16.043 1.00 43.89  ? 442  HIS A CD2 1 
ATOM   1182 C  CE1 . HIS A 1 179 ? -26.515 -15.464 -16.349 1.00 49.77  ? 442  HIS A CE1 1 
ATOM   1183 N  NE2 . HIS A 1 179 ? -26.328 -14.457 -15.465 1.00 47.32  ? 442  HIS A NE2 1 
ATOM   1184 N  N   . LEU A 1 180 ? -29.044 -10.114 -19.756 0.50 68.99  ? 443  LEU A N   1 
ATOM   1185 C  CA  . LEU A 1 180 ? -29.365 -9.226  -20.911 0.50 67.96  ? 443  LEU A CA  1 
ATOM   1186 C  C   . LEU A 1 180 ? -28.884 -7.800  -20.611 0.50 64.83  ? 443  LEU A C   1 
ATOM   1187 O  O   . LEU A 1 180 ? -28.504 -7.094  -21.562 0.50 65.46  ? 443  LEU A O   1 
ATOM   1188 C  CB  . LEU A 1 180 ? -30.874 -9.263  -21.179 0.50 67.44  ? 443  LEU A CB  1 
ATOM   1189 C  CG  . LEU A 1 180 ? -31.413 -10.564 -21.775 0.50 66.23  ? 443  LEU A CG  1 
ATOM   1190 C  CD1 . LEU A 1 180 ? -32.930 -10.525 -21.879 0.50 66.69  ? 443  LEU A CD1 1 
ATOM   1191 C  CD2 . LEU A 1 180 ? -30.798 -10.841 -23.139 0.50 67.19  ? 443  LEU A CD2 1 
ATOM   1192 N  N   . GLU A 1 181 ? -28.887 -7.413  -19.331 1.00 66.19  ? 444  GLU A N   1 
ATOM   1193 C  CA  . GLU A 1 181 ? -28.372 -6.102  -18.845 1.00 71.88  ? 444  GLU A CA  1 
ATOM   1194 C  C   . GLU A 1 181 ? -26.844 -6.126  -18.637 1.00 78.78  ? 444  GLU A C   1 
ATOM   1195 O  O   . GLU A 1 181 ? -26.283 -5.050  -18.337 1.00 72.72  ? 444  GLU A O   1 
ATOM   1196 C  CB  . GLU A 1 181 ? -29.020 -5.842  -17.483 1.00 86.72  ? 444  GLU A CB  1 
ATOM   1197 C  CG  . GLU A 1 181 ? -29.626 -4.471  -17.269 1.00 88.53  ? 444  GLU A CG  1 
ATOM   1198 C  CD  . GLU A 1 181 ? -30.320 -4.386  -15.913 1.00 90.48  ? 444  GLU A CD  1 
ATOM   1199 O  OE1 . GLU A 1 181 ? -30.049 -3.424  -15.166 1.00 93.46  ? 444  GLU A OE1 1 
ATOM   1200 O  OE2 . GLU A 1 181 ? -31.112 -5.312  -15.587 1.00 77.85  ? 444  GLU A OE2 1 
ATOM   1201 N  N   . GLY A 1 182 ? -26.200 -7.305  -18.701 1.00 76.29  ? 445  GLY A N   1 
ATOM   1202 C  CA  . GLY A 1 182 ? -24.739 -7.487  -18.526 1.00 63.50  ? 445  GLY A CA  1 
ATOM   1203 C  C   . GLY A 1 182 ? -24.299 -7.665  -17.069 1.00 57.61  ? 445  GLY A C   1 
ATOM   1204 O  O   . GLY A 1 182 ? -23.121 -7.397  -16.746 1.00 65.02  ? 445  GLY A O   1 
ATOM   1205 N  N   . LYS A 1 183 ? -25.196 -8.170  -16.216 0.50 56.98  ? 446  LYS A N   1 
ATOM   1206 C  CA  . LYS A 1 183 ? -24.986 -8.327  -14.750 0.50 60.06  ? 446  LYS A CA  1 
ATOM   1207 C  C   . LYS A 1 183 ? -25.480 -9.718  -14.324 0.50 56.04  ? 446  LYS A C   1 
ATOM   1208 O  O   . LYS A 1 183 ? -26.337 -10.265 -15.032 0.50 57.56  ? 446  LYS A O   1 
ATOM   1209 C  CB  . LYS A 1 183 ? -25.713 -7.192  -14.015 0.50 67.61  ? 446  LYS A CB  1 
ATOM   1210 C  CG  . LYS A 1 183 ? -25.360 -5.780  -14.481 0.50 71.62  ? 446  LYS A CG  1 
ATOM   1211 C  CD  . LYS A 1 183 ? -26.288 -4.695  -13.956 0.50 77.53  ? 446  LYS A CD  1 
ATOM   1212 C  CE  . LYS A 1 183 ? -25.842 -3.293  -14.329 0.50 79.99  ? 446  LYS A CE  1 
ATOM   1213 N  NZ  . LYS A 1 183 ? -26.761 -2.259  -13.793 0.50 81.97  ? 446  LYS A NZ  1 
ATOM   1214 N  N   . CYS A 1 184 ? -24.939 -10.275 -13.232 0.50 57.15  ? 447  CYS A N   1 
ATOM   1215 C  CA  . CYS A 1 184 ? -25.320 -11.591 -12.633 0.50 56.29  ? 447  CYS A CA  1 
ATOM   1216 C  C   . CYS A 1 184 ? -25.453 -11.413 -11.117 0.50 56.55  ? 447  CYS A C   1 
ATOM   1217 O  O   . CYS A 1 184 ? -24.860 -10.452 -10.598 0.50 57.41  ? 447  CYS A O   1 
ATOM   1218 C  CB  . CYS A 1 184 ? -24.288 -12.670 -12.969 0.50 57.30  ? 447  CYS A CB  1 
ATOM   1219 S  SG  . CYS A 1 184 ? -24.387 -14.173 -11.953 0.50 56.49  ? 447  CYS A SG  1 
ATOM   1220 N  N   . GLU A 1 185 ? -26.190 -12.294 -10.432 0.50 58.36  ? 448  GLU A N   1 
ATOM   1221 C  CA  . GLU A 1 185 ? -26.415 -12.197 -8.965  0.50 61.22  ? 448  GLU A CA  1 
ATOM   1222 C  C   . GLU A 1 185 ? -26.288 -13.571 -8.300  0.50 64.43  ? 448  GLU A C   1 
ATOM   1223 O  O   . GLU A 1 185 ? -25.823 -13.614 -7.141  0.50 65.91  ? 448  GLU A O   1 
ATOM   1224 C  CB  . GLU A 1 185 ? -27.797 -11.612 -8.648  0.50 66.05  ? 448  GLU A CB  1 
ATOM   1225 C  CG  . GLU A 1 185 ? -28.036 -11.406 -7.157  0.50 65.50  ? 448  GLU A CG  1 
ATOM   1226 C  CD  . GLU A 1 185 ? -29.462 -11.083 -6.731  0.50 65.42  ? 448  GLU A CD  1 
ATOM   1227 O  OE1 . GLU A 1 185 ? -29.653 -10.024 -6.098  0.50 64.29  ? 448  GLU A OE1 1 
ATOM   1228 O  OE2 . GLU A 1 185 ? -30.376 -11.898 -7.005  0.50 63.62  ? 448  GLU A OE2 1 
ATOM   1229 N  N   . THR A 1 186 ? -26.703 -14.646 -8.978  0.50 61.64  ? 449  THR A N   1 
ATOM   1230 C  CA  . THR A 1 186 ? -26.898 -15.978 -8.347  0.50 61.34  ? 449  THR A CA  1 
ATOM   1231 C  C   . THR A 1 186 ? -26.168 -17.077 -9.125  0.50 57.08  ? 449  THR A C   1 
ATOM   1232 O  O   . THR A 1 186 ? -26.424 -18.254 -8.816  0.50 57.48  ? 449  THR A O   1 
ATOM   1233 C  CB  . THR A 1 186 ? -28.390 -16.305 -8.208  0.50 67.02  ? 449  THR A CB  1 
ATOM   1234 O  OG1 . THR A 1 186 ? -28.866 -16.848 -9.442  0.50 70.09  ? 449  THR A OG1 1 
ATOM   1235 C  CG2 . THR A 1 186 ? -29.213 -15.094 -7.825  0.50 68.42  ? 449  THR A CG2 1 
ATOM   1236 N  N   . CYS A 1 187 ? -25.292 -16.725 -10.074 0.50 52.64  ? 450  CYS A N   1 
ATOM   1237 C  CA  . CYS A 1 187 ? -24.452 -17.703 -10.825 0.50 51.15  ? 450  CYS A CA  1 
ATOM   1238 C  C   . CYS A 1 187 ? -23.079 -17.844 -10.143 0.50 52.90  ? 450  CYS A C   1 
ATOM   1239 O  O   . CYS A 1 187 ? -22.102 -17.211 -10.610 0.50 54.26  ? 450  CYS A O   1 
ATOM   1240 C  CB  . CYS A 1 187 ? -24.317 -17.322 -12.296 0.50 48.25  ? 450  CYS A CB  1 
ATOM   1241 S  SG  . CYS A 1 187 ? -25.879 -17.421 -13.218 0.50 41.68  ? 450  CYS A SG  1 
ATOM   1242 N  N   . VAL A 1 188 ? -23.025 -18.658 -9.081  0.50 53.38  ? 451  VAL A N   1 
ATOM   1243 C  CA  . VAL A 1 188 ? -21.820 -18.920 -8.236  0.50 56.98  ? 451  VAL A CA  1 
ATOM   1244 C  C   . VAL A 1 188 ? -21.639 -20.436 -8.080  0.50 57.53  ? 451  VAL A C   1 
ATOM   1245 O  O   . VAL A 1 188 ? -22.634 -21.137 -7.819  0.50 55.39  ? 451  VAL A O   1 
ATOM   1246 C  CB  . VAL A 1 188 ? -21.945 -18.240 -6.858  0.50 59.35  ? 451  VAL A CB  1 
ATOM   1247 C  CG1 . VAL A 1 188 ? -20.884 -18.734 -5.880  0.50 59.09  ? 451  VAL A CG1 1 
ATOM   1248 C  CG2 . VAL A 1 188 ? -21.914 -16.724 -6.975  0.50 60.02  ? 451  VAL A CG2 1 
ATOM   1249 N  N   . TYR A 1 189 ? -20.401 -20.914 -8.205  0.50 61.68  ? 452  TYR A N   1 
ATOM   1250 C  CA  . TYR A 1 189 ? -20.047 -22.354 -8.121  0.50 64.34  ? 452  TYR A CA  1 
ATOM   1251 C  C   . TYR A 1 189 ? -19.769 -22.743 -6.666  0.50 67.55  ? 452  TYR A C   1 
ATOM   1252 O  O   . TYR A 1 189 ? -19.339 -21.885 -5.872  0.50 68.29  ? 452  TYR A O   1 
ATOM   1253 C  CB  . TYR A 1 189 ? -18.843 -22.660 -9.011  0.50 62.28  ? 452  TYR A CB  1 
ATOM   1254 C  CG  . TYR A 1 189 ? -19.093 -22.442 -10.480 0.50 63.36  ? 452  TYR A CG  1 
ATOM   1255 C  CD1 . TYR A 1 189 ? -19.752 -23.392 -11.243 0.50 63.75  ? 452  TYR A CD1 1 
ATOM   1256 C  CD2 . TYR A 1 189 ? -18.677 -21.280 -11.107 0.50 63.67  ? 452  TYR A CD2 1 
ATOM   1257 C  CE1 . TYR A 1 189 ? -19.989 -23.195 -12.594 0.50 64.67  ? 452  TYR A CE1 1 
ATOM   1258 C  CE2 . TYR A 1 189 ? -18.903 -21.068 -12.457 0.50 64.82  ? 452  TYR A CE2 1 
ATOM   1259 C  CZ  . TYR A 1 189 ? -19.561 -22.029 -13.203 0.50 65.25  ? 452  TYR A CZ  1 
ATOM   1260 O  OH  . TYR A 1 189 ? -19.792 -21.832 -14.534 0.50 69.19  ? 452  TYR A OH  1 
ATOM   1261 N  N   . ASN A 1 190 ? -20.020 -24.015 -6.347  0.50 73.97  ? 453  ASN A N   1 
ATOM   1262 C  CA  . ASN A 1 190 ? -19.688 -24.654 -5.048  0.50 78.50  ? 453  ASN A CA  1 
ATOM   1263 C  C   . ASN A 1 190 ? -18.733 -25.822 -5.319  0.50 83.08  ? 453  ASN A C   1 
ATOM   1264 O  O   . ASN A 1 190 ? -19.227 -26.933 -5.601  0.50 80.84  ? 453  ASN A O   1 
ATOM   1265 C  CB  . ASN A 1 190 ? -20.961 -25.068 -4.310  0.50 79.48  ? 453  ASN A CB  1 
ATOM   1266 C  CG  . ASN A 1 190 ? -21.980 -23.950 -4.282  0.50 79.74  ? 453  ASN A CG  1 
ATOM   1267 O  OD1 . ASN A 1 190 ? -22.165 -23.251 -5.276  0.50 83.30  ? 453  ASN A OD1 1 
ATOM   1268 N  ND2 . ASN A 1 190 ? -22.634 -23.764 -3.147  0.50 79.82  ? 453  ASN A ND2 1 
ATOM   1269 N  N   . MET A 1 191 ? -17.423 -25.554 -5.248  0.50 91.56  ? 454  MET A N   1 
ATOM   1270 C  CA  . MET A 1 191 ? -16.319 -26.496 -5.587  0.50 95.56  ? 454  MET A CA  1 
ATOM   1271 C  C   . MET A 1 191 ? -16.379 -27.717 -4.663  0.50 97.10  ? 454  MET A C   1 
ATOM   1272 O  O   . MET A 1 191 ? -16.307 -27.530 -3.432  0.50 98.57  ? 454  MET A O   1 
ATOM   1273 C  CB  . MET A 1 191 ? -14.959 -25.805 -5.436  0.50 99.07  ? 454  MET A CB  1 
ATOM   1274 C  CG  . MET A 1 191 ? -13.776 -26.721 -5.683  0.50 104.76 ? 454  MET A CG  1 
ATOM   1275 S  SD  . MET A 1 191 ? -12.201 -25.822 -5.784  0.50 111.20 ? 454  MET A SD  1 
ATOM   1276 C  CE  . MET A 1 191 ? -12.550 -24.676 -7.116  0.50 106.86 ? 454  MET A CE  1 
ATOM   1277 N  N   . MET A 1 192 ? -16.497 -28.916 -5.247  0.50 98.87  ? 455  MET A N   1 
ATOM   1278 C  CA  . MET A 1 192 ? -16.666 -30.205 -4.520  0.50 96.95  ? 455  MET A CA  1 
ATOM   1279 C  C   . MET A 1 192 ? -16.260 -31.366 -5.438  0.50 94.79  ? 455  MET A C   1 
ATOM   1280 O  O   . MET A 1 192 ? -15.154 -31.281 -6.010  0.50 91.43  ? 455  MET A O   1 
ATOM   1281 C  CB  . MET A 1 192 ? -18.123 -30.392 -4.079  0.50 97.07  ? 455  MET A CB  1 
ATOM   1282 C  CG  . MET A 1 192 ? -18.671 -29.219 -3.278  0.50 95.50  ? 455  MET A CG  1 
ATOM   1283 S  SD  . MET A 1 192 ? -20.483 -29.212 -3.160  0.50 93.87  ? 455  MET A SD  1 
ATOM   1284 C  CE  . MET A 1 192 ? -20.760 -30.783 -2.343  0.50 96.14  ? 455  MET A CE  1 
ATOM   1285 N  N   . ALA A 1 210 ? -11.372 -30.196 -8.799  0.50 85.50  ? 473  ALA A N   1 
ATOM   1286 C  CA  . ALA A 1 210 ? -12.573 -30.662 -8.066  0.50 86.32  ? 473  ALA A CA  1 
ATOM   1287 C  C   . ALA A 1 210 ? -13.750 -30.798 -9.041  0.50 82.77  ? 473  ALA A C   1 
ATOM   1288 O  O   . ALA A 1 210 ? -13.504 -31.086 -10.230 0.50 81.47  ? 473  ALA A O   1 
ATOM   1289 C  CB  . ALA A 1 210 ? -12.890 -29.703 -6.942  0.50 84.78  ? 473  ALA A CB  1 
ATOM   1290 N  N   . ILE A 1 211 ? -14.978 -30.625 -8.540  0.50 81.58  ? 474  ILE A N   1 
ATOM   1291 C  CA  . ILE A 1 211 ? -16.226 -30.489 -9.352  0.50 78.84  ? 474  ILE A CA  1 
ATOM   1292 C  C   . ILE A 1 211 ? -17.023 -29.306 -8.793  0.50 74.36  ? 474  ILE A C   1 
ATOM   1293 O  O   . ILE A 1 211 ? -17.343 -29.322 -7.587  0.50 71.92  ? 474  ILE A O   1 
ATOM   1294 C  CB  . ILE A 1 211 ? -17.059 -31.788 -9.352  0.50 80.39  ? 474  ILE A CB  1 
ATOM   1295 C  CG1 . ILE A 1 211 ? -16.246 -32.992 -9.836  0.50 83.43  ? 474  ILE A CG1 1 
ATOM   1296 C  CG2 . ILE A 1 211 ? -18.336 -31.610 -10.161 0.50 77.28  ? 474  ILE A CG2 1 
ATOM   1297 C  CD1 . ILE A 1 211 ? -15.359 -33.603 -8.775  0.50 84.43  ? 474  ILE A CD1 1 
ATOM   1298 N  N   . TRP A 1 212 ? -17.303 -28.311 -9.637  0.50 70.01  ? 475  TRP A N   1 
ATOM   1299 C  CA  . TRP A 1 212 ? -18.032 -27.070 -9.266  0.50 68.19  ? 475  TRP A CA  1 
ATOM   1300 C  C   . TRP A 1 212 ? -19.508 -27.225 -9.646  0.50 67.50  ? 475  TRP A C   1 
ATOM   1301 O  O   . TRP A 1 212 ? -19.800 -27.278 -10.853 0.50 68.85  ? 475  TRP A O   1 
ATOM   1302 C  CB  . TRP A 1 212 ? -17.392 -25.850 -9.943  0.50 65.45  ? 475  TRP A CB  1 
ATOM   1303 C  CG  . TRP A 1 212 ? -15.903 -25.769 -9.788  0.50 62.56  ? 475  TRP A CG  1 
ATOM   1304 C  CD1 . TRP A 1 212 ? -15.081 -26.700 -9.221  0.50 62.92  ? 475  TRP A CD1 1 
ATOM   1305 C  CD2 . TRP A 1 212 ? -15.046 -24.712 -10.255 0.50 60.27  ? 475  TRP A CD2 1 
ATOM   1306 N  NE1 . TRP A 1 212 ? -13.777 -26.286 -9.284  0.50 62.63  ? 475  TRP A NE1 1 
ATOM   1307 C  CE2 . TRP A 1 212 ? -13.725 -25.070 -9.913  0.50 60.53  ? 475  TRP A CE2 1 
ATOM   1308 C  CE3 . TRP A 1 212 ? -15.265 -23.498 -10.915 0.50 56.07  ? 475  TRP A CE3 1 
ATOM   1309 C  CZ2 . TRP A 1 212 ? -12.633 -24.257 -10.212 0.50 59.91  ? 475  TRP A CZ2 1 
ATOM   1310 C  CZ3 . TRP A 1 212 ? -14.187 -22.696 -11.212 0.50 56.49  ? 475  TRP A CZ3 1 
ATOM   1311 C  CH2 . TRP A 1 212 ? -12.889 -23.074 -10.868 0.50 58.41  ? 475  TRP A CH2 1 
ATOM   1312 N  N   . TYR A 1 213 ? -20.390 -27.318 -8.645  0.50 68.91  ? 476  TYR A N   1 
ATOM   1313 C  CA  . TYR A 1 213 ? -21.867 -27.369 -8.801  0.50 68.15  ? 476  TYR A CA  1 
ATOM   1314 C  C   . TYR A 1 213 ? -22.441 -25.955 -8.620  0.50 68.66  ? 476  TYR A C   1 
ATOM   1315 O  O   . TYR A 1 213 ? -22.100 -25.288 -7.623  0.50 69.78  ? 476  TYR A O   1 
ATOM   1316 C  CB  . TYR A 1 213 ? -22.479 -28.349 -7.795  0.50 72.42  ? 476  TYR A CB  1 
ATOM   1317 C  CG  . TYR A 1 213 ? -21.941 -29.759 -7.849  0.50 77.23  ? 476  TYR A CG  1 
ATOM   1318 C  CD1 . TYR A 1 213 ? -20.679 -30.066 -7.366  0.50 80.68  ? 476  TYR A CD1 1 
ATOM   1319 C  CD2 . TYR A 1 213 ? -22.701 -30.798 -8.361  0.50 79.74  ? 476  TYR A CD2 1 
ATOM   1320 C  CE1 . TYR A 1 213 ? -20.183 -31.362 -7.402  0.50 82.38  ? 476  TYR A CE1 1 
ATOM   1321 C  CE2 . TYR A 1 213 ? -22.221 -32.097 -8.407  0.50 81.04  ? 476  TYR A CE2 1 
ATOM   1322 C  CZ  . TYR A 1 213 ? -20.957 -32.384 -7.922  0.50 81.71  ? 476  TYR A CZ  1 
ATOM   1323 O  OH  . TYR A 1 213 ? -20.479 -33.664 -7.961  0.50 78.00  ? 476  TYR A OH  1 
ATOM   1324 N  N   . MET A 1 214 ? -23.276 -25.510 -9.566  0.50 65.29  ? 477  MET A N   1 
ATOM   1325 C  CA  . MET A 1 214 ? -24.047 -24.236 -9.497  0.50 60.20  ? 477  MET A CA  1 
ATOM   1326 C  C   . MET A 1 214 ? -25.490 -24.558 -9.110  0.50 53.88  ? 477  MET A C   1 
ATOM   1327 O  O   . MET A 1 214 ? -25.805 -25.753 -9.012  0.50 53.00  ? 477  MET A O   1 
ATOM   1328 C  CB  . MET A 1 214 ? -24.056 -23.518 -10.848 0.50 60.64  ? 477  MET A CB  1 
ATOM   1329 C  CG  . MET A 1 214 ? -23.117 -22.339 -10.922 0.50 60.47  ? 477  MET A CG  1 
ATOM   1330 S  SD  . MET A 1 214 ? -23.208 -21.549 -12.545 0.50 61.84  ? 477  MET A SD  1 
ATOM   1331 C  CE  . MET A 1 214 ? -22.203 -20.094 -12.262 0.50 60.75  ? 477  MET A CE  1 
ATOM   1332 N  N   . TRP A 1 215 ? -26.332 -23.540 -8.906  0.50 52.18  ? 478  TRP A N   1 
ATOM   1333 C  CA  . TRP A 1 215 ? -27.798 -23.734 -8.733  0.50 53.02  ? 478  TRP A CA  1 
ATOM   1334 C  C   . TRP A 1 215 ? -28.414 -23.991 -10.116 0.50 50.50  ? 478  TRP A C   1 
ATOM   1335 O  O   . TRP A 1 215 ? -27.744 -23.666 -11.122 0.50 45.23  ? 478  TRP A O   1 
ATOM   1336 C  CB  . TRP A 1 215 ? -28.456 -22.575 -7.964  0.50 52.55  ? 478  TRP A CB  1 
ATOM   1337 C  CG  . TRP A 1 215 ? -28.773 -21.322 -8.730  0.50 55.21  ? 478  TRP A CG  1 
ATOM   1338 C  CD1 . TRP A 1 215 ? -27.887 -20.415 -9.235  0.50 54.38  ? 478  TRP A CD1 1 
ATOM   1339 C  CD2 . TRP A 1 215 ? -30.084 -20.783 -8.997  0.50 54.73  ? 478  TRP A CD2 1 
ATOM   1340 N  NE1 . TRP A 1 215 ? -28.550 -19.376 -9.835  0.50 55.26  ? 478  TRP A NE1 1 
ATOM   1341 C  CE2 . TRP A 1 215 ? -29.899 -19.572 -9.703  0.50 54.89  ? 478  TRP A CE2 1 
ATOM   1342 C  CE3 . TRP A 1 215 ? -31.390 -21.214 -8.730  0.50 53.15  ? 478  TRP A CE3 1 
ATOM   1343 C  CZ2 . TRP A 1 215 ? -30.969 -18.793 -10.142 0.50 52.82  ? 478  TRP A CZ2 1 
ATOM   1344 C  CZ3 . TRP A 1 215 ? -32.446 -20.443 -9.165  0.50 53.64  ? 478  TRP A CZ3 1 
ATOM   1345 C  CH2 . TRP A 1 215 ? -32.236 -19.249 -9.857  0.50 53.85  ? 478  TRP A CH2 1 
ATOM   1346 N  N   . LEU A 1 216 ? -29.602 -24.605 -10.159 0.50 48.07  ? 479  LEU A N   1 
ATOM   1347 C  CA  . LEU A 1 216 ? -30.265 -25.062 -11.409 0.50 49.20  ? 479  LEU A CA  1 
ATOM   1348 C  C   . LEU A 1 216 ? -30.502 -23.874 -12.347 0.50 47.13  ? 479  LEU A C   1 
ATOM   1349 O  O   . LEU A 1 216 ? -30.326 -24.046 -13.571 0.50 47.58  ? 479  LEU A O   1 
ATOM   1350 C  CB  . LEU A 1 216 ? -31.591 -25.747 -11.074 0.50 49.77  ? 479  LEU A CB  1 
ATOM   1351 C  CG  . LEU A 1 216 ? -32.225 -26.479 -12.254 0.50 50.11  ? 479  LEU A CG  1 
ATOM   1352 C  CD1 . LEU A 1 216 ? -31.295 -27.578 -12.755 0.50 50.43  ? 479  LEU A CD1 1 
ATOM   1353 C  CD2 . LEU A 1 216 ? -33.586 -27.044 -11.882 0.50 48.62  ? 479  LEU A CD2 1 
ATOM   1354 N  N   . GLY A 1 217 ? -30.892 -22.726 -11.787 0.50 45.66  ? 480  GLY A N   1 
ATOM   1355 C  CA  . GLY A 1 217 ? -31.166 -21.485 -12.535 0.50 46.37  ? 480  GLY A CA  1 
ATOM   1356 C  C   . GLY A 1 217 ? -29.992 -21.093 -13.415 0.50 42.89  ? 480  GLY A C   1 
ATOM   1357 O  O   . GLY A 1 217 ? -30.226 -20.737 -14.580 0.50 39.35  ? 480  GLY A O   1 
ATOM   1358 N  N   . ALA A 1 218 ? -28.774 -21.163 -12.868 0.50 44.87  ? 481  ALA A N   1 
ATOM   1359 C  CA  . ALA A 1 218 ? -27.499 -20.850 -13.562 0.50 42.26  ? 481  ALA A CA  1 
ATOM   1360 C  C   . ALA A 1 218 ? -27.206 -21.947 -14.592 0.50 42.29  ? 481  ALA A C   1 
ATOM   1361 O  O   . ALA A 1 218 ? -26.743 -21.605 -15.698 0.50 40.30  ? 481  ALA A O   1 
ATOM   1362 C  CB  . ALA A 1 218 ? -26.383 -20.718 -12.556 0.50 40.92  ? 481  ALA A CB  1 
ATOM   1363 N  N   . ARG A 1 219 ? -27.489 -23.206 -14.233 0.50 46.01  ? 482  ARG A N   1 
ATOM   1364 C  CA  . ARG A 1 219 ? -27.292 -24.410 -15.089 0.50 48.60  ? 482  ARG A CA  1 
ATOM   1365 C  C   . ARG A 1 219 ? -28.210 -24.312 -16.307 0.50 48.73  ? 482  ARG A C   1 
ATOM   1366 O  O   . ARG A 1 219 ? -27.689 -24.316 -17.453 0.50 40.87  ? 482  ARG A O   1 
ATOM   1367 C  CB  . ARG A 1 219 ? -27.608 -25.701 -14.330 0.50 51.14  ? 482  ARG A CB  1 
ATOM   1368 C  CG  . ARG A 1 219 ? -26.389 -26.548 -13.998 0.50 58.62  ? 482  ARG A CG  1 
ATOM   1369 C  CD  . ARG A 1 219 ? -25.527 -25.905 -12.927 0.50 62.24  ? 482  ARG A CD  1 
ATOM   1370 N  NE  . ARG A 1 219 ? -24.272 -26.606 -12.670 0.50 64.01  ? 482  ARG A NE  1 
ATOM   1371 C  CZ  . ARG A 1 219 ? -23.136 -26.370 -13.314 0.50 59.81  ? 482  ARG A CZ  1 
ATOM   1372 N  NH1 . ARG A 1 219 ? -23.098 -25.470 -14.281 0.50 59.94  ? 482  ARG A NH1 1 
ATOM   1373 N  NH2 . ARG A 1 219 ? -22.046 -27.043 -12.996 0.50 60.35  ? 482  ARG A NH2 1 
ATOM   1374 N  N   . PHE A 1 220 ? -29.524 -24.238 -16.071 0.50 47.06  ? 483  PHE A N   1 
ATOM   1375 C  CA  . PHE A 1 220 ? -30.518 -24.041 -17.153 0.50 46.38  ? 483  PHE A CA  1 
ATOM   1376 C  C   . PHE A 1 220 ? -30.001 -22.948 -18.089 0.50 45.52  ? 483  PHE A C   1 
ATOM   1377 O  O   . PHE A 1 220 ? -29.924 -23.183 -19.315 0.50 45.92  ? 483  PHE A O   1 
ATOM   1378 C  CB  . PHE A 1 220 ? -31.888 -23.577 -16.658 0.50 46.11  ? 483  PHE A CB  1 
ATOM   1379 C  CG  . PHE A 1 220 ? -32.650 -22.904 -17.770 0.50 42.25  ? 483  PHE A CG  1 
ATOM   1380 C  CD1 . PHE A 1 220 ? -33.149 -23.651 -18.824 0.50 42.87  ? 483  PHE A CD1 1 
ATOM   1381 C  CD2 . PHE A 1 220 ? -32.773 -21.526 -17.822 0.50 40.94  ? 483  PHE A CD2 1 
ATOM   1382 C  CE1 . PHE A 1 220 ? -33.806 -23.040 -19.879 0.50 41.82  ? 483  PHE A CE1 1 
ATOM   1383 C  CE2 . PHE A 1 220 ? -33.433 -20.915 -18.878 0.50 42.16  ? 483  PHE A CE2 1 
ATOM   1384 C  CZ  . PHE A 1 220 ? -33.952 -21.673 -19.902 0.50 41.42  ? 483  PHE A CZ  1 
ATOM   1385 N  N   . LEU A 1 221 ? -29.682 -21.785 -17.513 0.50 43.37  ? 484  LEU A N   1 
ATOM   1386 C  CA  . LEU A 1 221 ? -29.174 -20.594 -18.244 0.50 44.65  ? 484  LEU A CA  1 
ATOM   1387 C  C   . LEU A 1 221 ? -27.964 -21.002 -19.096 0.50 45.52  ? 484  LEU A C   1 
ATOM   1388 O  O   . LEU A 1 221 ? -28.019 -20.815 -20.335 0.50 45.04  ? 484  LEU A O   1 
ATOM   1389 C  CB  . LEU A 1 221 ? -28.811 -19.499 -17.237 0.50 46.22  ? 484  LEU A CB  1 
ATOM   1390 C  CG  . LEU A 1 221 ? -29.989 -18.903 -16.468 0.50 47.09  ? 484  LEU A CG  1 
ATOM   1391 C  CD1 . LEU A 1 221 ? -29.576 -17.622 -15.759 0.50 51.12  ? 484  LEU A CD1 1 
ATOM   1392 C  CD2 . LEU A 1 221 ? -31.165 -18.641 -17.393 0.50 48.44  ? 484  LEU A CD2 1 
ATOM   1393 N  N   . GLU A 1 222 ? -26.912 -21.535 -18.464 0.50 43.21  ? 485  GLU A N   1 
ATOM   1394 C  CA  . GLU A 1 222 ? -25.752 -22.125 -19.185 0.50 42.13  ? 485  GLU A CA  1 
ATOM   1395 C  C   . GLU A 1 222 ? -26.291 -22.929 -20.377 0.50 39.25  ? 485  GLU A C   1 
ATOM   1396 O  O   . GLU A 1 222 ? -25.815 -22.716 -21.500 0.50 39.10  ? 485  GLU A O   1 
ATOM   1397 C  CB  . GLU A 1 222 ? -24.921 -23.013 -18.250 0.50 42.76  ? 485  GLU A CB  1 
ATOM   1398 C  CG  . GLU A 1 222 ? -23.876 -23.847 -18.974 0.50 41.46  ? 485  GLU A CG  1 
ATOM   1399 C  CD  . GLU A 1 222 ? -22.974 -24.676 -18.074 0.50 40.26  ? 485  GLU A CD  1 
ATOM   1400 O  OE1 . GLU A 1 222 ? -21.840 -24.230 -17.802 0.50 40.42  ? 485  GLU A OE1 1 
ATOM   1401 O  OE2 . GLU A 1 222 ? -23.401 -25.770 -17.657 0.50 40.49  ? 485  GLU A OE2 1 
ATOM   1402 N  N   . PHE A 1 223 ? -27.264 -23.809 -20.128 1.00 38.06  ? 486  PHE A N   1 
ATOM   1403 C  CA  . PHE A 1 223 ? -27.769 -24.794 -21.123 1.00 42.02  ? 486  PHE A CA  1 
ATOM   1404 C  C   . PHE A 1 223 ? -28.498 -24.082 -22.246 1.00 42.82  ? 486  PHE A C   1 
ATOM   1405 O  O   . PHE A 1 223 ? -28.292 -24.427 -23.420 1.00 40.46  ? 486  PHE A O   1 
ATOM   1406 C  CB  . PHE A 1 223 ? -28.665 -25.828 -20.463 1.00 41.27  ? 486  PHE A CB  1 
ATOM   1407 C  CG  . PHE A 1 223 ? -29.384 -26.757 -21.399 1.00 42.02  ? 486  PHE A CG  1 
ATOM   1408 C  CD1 . PHE A 1 223 ? -28.738 -27.853 -21.936 1.00 40.77  ? 486  PHE A CD1 1 
ATOM   1409 C  CD2 . PHE A 1 223 ? -30.734 -26.570 -21.676 1.00 43.54  ? 486  PHE A CD2 1 
ATOM   1410 C  CE1 . PHE A 1 223 ? -29.421 -28.748 -22.749 1.00 47.10  ? 486  PHE A CE1 1 
ATOM   1411 C  CE2 . PHE A 1 223 ? -31.418 -27.476 -22.476 1.00 43.34  ? 486  PHE A CE2 1 
ATOM   1412 C  CZ  . PHE A 1 223 ? -30.766 -28.572 -22.996 1.00 43.28  ? 486  PHE A CZ  1 
ATOM   1413 N  N   . GLU A 1 224 ? -29.220 -23.030 -21.893 1.00 45.94  ? 487  GLU A N   1 
ATOM   1414 C  CA  . GLU A 1 224 ? -29.994 -22.251 -22.874 1.00 47.26  ? 487  GLU A CA  1 
ATOM   1415 C  C   . GLU A 1 224 ? -29.017 -21.622 -23.879 1.00 48.00  ? 487  GLU A C   1 
ATOM   1416 O  O   . GLU A 1 224 ? -29.307 -21.626 -25.111 1.00 40.80  ? 487  GLU A O   1 
ATOM   1417 C  CB  . GLU A 1 224 ? -30.840 -21.211 -22.140 1.00 49.37  ? 487  GLU A CB  1 
ATOM   1418 C  CG  . GLU A 1 224 ? -31.469 -20.183 -23.062 1.00 57.57  ? 487  GLU A CG  1 
ATOM   1419 C  CD  . GLU A 1 224 ? -32.427 -19.239 -22.353 1.00 58.20  ? 487  GLU A CD  1 
ATOM   1420 O  OE1 . GLU A 1 224 ? -33.679 -19.484 -22.445 1.00 51.30  ? 487  GLU A OE1 1 
ATOM   1421 O  OE2 . GLU A 1 224 ? -31.931 -18.259 -21.755 1.00 48.03  ? 487  GLU A OE2 1 
ATOM   1422 N  N   . ALA A 1 225 ? -27.876 -21.132 -23.408 1.00 36.20  ? 488  ALA A N   1 
ATOM   1423 C  CA  . ALA A 1 225 ? -26.965 -20.336 -24.257 1.00 35.15  ? 488  ALA A CA  1 
ATOM   1424 C  C   . ALA A 1 225 ? -25.974 -21.238 -24.982 1.00 34.67  ? 488  ALA A C   1 
ATOM   1425 O  O   . ALA A 1 225 ? -25.657 -20.889 -26.153 1.00 36.06  ? 488  ALA A O   1 
ATOM   1426 C  CB  . ALA A 1 225 ? -26.265 -19.301 -23.442 1.00 37.30  ? 488  ALA A CB  1 
ATOM   1427 N  N   . LEU A 1 226 ? -25.519 -22.346 -24.372 1.00 35.86  ? 489  LEU A N   1 
ATOM   1428 C  CA  . LEU A 1 226 ? -24.358 -23.101 -24.940 1.00 32.56  ? 489  LEU A CA  1 
ATOM   1429 C  C   . LEU A 1 226 ? -24.666 -24.586 -25.100 1.00 33.16  ? 489  LEU A C   1 
ATOM   1430 O  O   . LEU A 1 226 ? -23.807 -25.333 -25.643 1.00 35.01  ? 489  LEU A O   1 
ATOM   1431 C  CB  . LEU A 1 226 ? -23.149 -22.862 -24.035 1.00 32.97  ? 489  LEU A CB  1 
ATOM   1432 C  CG  . LEU A 1 226 ? -22.613 -21.427 -23.994 1.00 34.76  ? 489  LEU A CG  1 
ATOM   1433 C  CD1 . LEU A 1 226 ? -21.338 -21.346 -23.173 1.00 43.50  ? 489  LEU A CD1 1 
ATOM   1434 C  CD2 . LEU A 1 226 ? -22.305 -20.900 -25.383 1.00 41.25  ? 489  LEU A CD2 1 
ATOM   1435 N  N   . GLY A 1 227 ? -25.895 -25.028 -24.806 1.00 30.84  ? 490  GLY A N   1 
ATOM   1436 C  CA  . GLY A 1 227 ? -26.256 -26.455 -24.889 1.00 31.94  ? 490  GLY A CA  1 
ATOM   1437 C  C   . GLY A 1 227 ? -26.293 -26.955 -26.309 1.00 28.49  ? 490  GLY A C   1 
ATOM   1438 O  O   . GLY A 1 227 ? -26.063 -28.203 -26.539 1.00 28.91  ? 490  GLY A O   1 
ATOM   1439 N  N   . PHE A 1 228 ? -26.429 -26.035 -27.256 1.00 31.25  ? 491  PHE A N   1 
ATOM   1440 C  CA  . PHE A 1 228 ? -26.457 -26.390 -28.690 1.00 32.55  ? 491  PHE A CA  1 
ATOM   1441 C  C   . PHE A 1 228 ? -25.186 -27.151 -29.085 1.00 28.94  ? 491  PHE A C   1 
ATOM   1442 O  O   . PHE A 1 228 ? -25.257 -28.002 -30.012 1.00 29.07  ? 491  PHE A O   1 
ATOM   1443 C  CB  . PHE A 1 228 ? -26.652 -25.176 -29.589 1.00 32.25  ? 491  PHE A CB  1 
ATOM   1444 C  CG  . PHE A 1 228 ? -25.497 -24.224 -29.654 1.00 26.92  ? 491  PHE A CG  1 
ATOM   1445 C  CD1 . PHE A 1 228 ? -25.363 -23.218 -28.709 1.00 33.42  ? 491  PHE A CD1 1 
ATOM   1446 C  CD2 . PHE A 1 228 ? -24.587 -24.306 -30.678 1.00 33.74  ? 491  PHE A CD2 1 
ATOM   1447 C  CE1 . PHE A 1 228 ? -24.299 -22.337 -28.759 1.00 33.89  ? 491  PHE A CE1 1 
ATOM   1448 C  CE2 . PHE A 1 228 ? -23.513 -23.434 -30.724 1.00 32.72  ? 491  PHE A CE2 1 
ATOM   1449 C  CZ  . PHE A 1 228 ? -23.374 -22.460 -29.767 1.00 34.04  ? 491  PHE A CZ  1 
ATOM   1450 N  N   . LEU A 1 229 ? -24.046 -26.862 -28.454 1.00 30.25  ? 492  LEU A N   1 
ATOM   1451 C  CA  . LEU A 1 229 ? -22.774 -27.531 -28.849 1.00 32.64  ? 492  LEU A CA  1 
ATOM   1452 C  C   . LEU A 1 229 ? -22.911 -29.047 -28.691 1.00 25.17  ? 492  LEU A C   1 
ATOM   1453 O  O   . LEU A 1 229 ? -22.499 -29.802 -29.578 1.00 33.31  ? 492  LEU A O   1 
ATOM   1454 C  CB  . LEU A 1 229 ? -21.653 -26.969 -27.981 1.00 32.31  ? 492  LEU A CB  1 
ATOM   1455 C  CG  . LEU A 1 229 ? -21.231 -25.538 -28.316 1.00 33.91  ? 492  LEU A CG  1 
ATOM   1456 C  CD1 . LEU A 1 229 ? -20.288 -25.042 -27.261 1.00 33.50  ? 492  LEU A CD1 1 
ATOM   1457 C  CD2 . LEU A 1 229 ? -20.598 -25.417 -29.676 1.00 32.93  ? 492  LEU A CD2 1 
ATOM   1458 N  N   . ASN A 1 230 ? -23.494 -29.454 -27.599 1.00 28.57  ? 493  ASN A N   1 
ATOM   1459 C  CA  . ASN A 1 230 ? -23.708 -30.894 -27.339 1.00 30.21  ? 493  ASN A CA  1 
ATOM   1460 C  C   . ASN A 1 230 ? -25.014 -31.378 -27.994 1.00 30.17  ? 493  ASN A C   1 
ATOM   1461 O  O   . ASN A 1 230 ? -25.005 -32.422 -28.673 1.00 29.90  ? 493  ASN A O   1 
ATOM   1462 C  CB  . ASN A 1 230 ? -23.780 -31.135 -25.837 1.00 36.73  ? 493  ASN A CB  1 
ATOM   1463 C  CG  . ASN A 1 230 ? -23.932 -32.617 -25.575 1.00 42.73  ? 493  ASN A CG  1 
ATOM   1464 O  OD1 . ASN A 1 230 ? -24.922 -33.069 -25.000 1.00 46.64  ? 493  ASN A OD1 1 
ATOM   1465 N  ND2 . ASN A 1 230 ? -22.954 -33.371 -26.037 1.00 40.90  ? 493  ASN A ND2 1 
ATOM   1466 N  N   . GLU A 1 231 ? -26.113 -30.643 -27.811 1.00 31.74  ? 494  GLU A N   1 
ATOM   1467 C  CA  . GLU A 1 231 ? -27.467 -31.116 -28.238 1.00 30.55  ? 494  GLU A CA  1 
ATOM   1468 C  C   . GLU A 1 231 ? -27.491 -31.288 -29.755 1.00 29.26  ? 494  GLU A C   1 
ATOM   1469 O  O   . GLU A 1 231 ? -28.209 -32.182 -30.211 1.00 30.90  ? 494  GLU A O   1 
ATOM   1470 C  CB  . GLU A 1 231 ? -28.579 -30.134 -27.813 1.00 33.96  ? 494  GLU A CB  1 
ATOM   1471 C  CG  . GLU A 1 231 ? -28.897 -30.116 -26.331 1.00 38.36  ? 494  GLU A CG  1 
ATOM   1472 C  CD  . GLU A 1 231 ? -29.381 -31.444 -25.765 1.00 44.67  ? 494  GLU A CD  1 
ATOM   1473 O  OE1 . GLU A 1 231 ? -30.137 -32.152 -26.458 1.00 43.38  ? 494  GLU A OE1 1 
ATOM   1474 O  OE2 . GLU A 1 231 ? -28.939 -31.789 -24.659 1.00 50.36  ? 494  GLU A OE2 1 
ATOM   1475 N  N   . ASP A 1 232 ? -26.763 -30.449 -30.525 1.00 28.26  ? 495  ASP A N   1 
ATOM   1476 C  CA  . ASP A 1 232 ? -26.721 -30.508 -32.006 1.00 26.48  ? 495  ASP A CA  1 
ATOM   1477 C  C   . ASP A 1 232 ? -25.353 -31.008 -32.505 1.00 30.56  ? 495  ASP A C   1 
ATOM   1478 O  O   . ASP A 1 232 ? -25.061 -30.891 -33.714 1.00 27.42  ? 495  ASP A O   1 
ATOM   1479 C  CB  . ASP A 1 232 ? -27.037 -29.128 -32.591 1.00 29.18  ? 495  ASP A CB  1 
ATOM   1480 C  CG  . ASP A 1 232 ? -28.358 -28.508 -32.118 1.00 29.76  ? 495  ASP A CG  1 
ATOM   1481 O  OD1 . ASP A 1 232 ? -29.227 -29.253 -31.739 1.00 35.37  ? 495  ASP A OD1 1 
ATOM   1482 O  OD2 . ASP A 1 232 ? -28.455 -27.308 -32.078 1.00 28.24  ? 495  ASP A OD2 1 
ATOM   1483 N  N   . HIS A 1 233 ? -24.577 -31.660 -31.644 1.00 29.91  ? 496  HIS A N   1 
ATOM   1484 C  CA  . HIS A 1 233 ? -23.461 -32.542 -32.077 1.00 28.73  ? 496  HIS A CA  1 
ATOM   1485 C  C   . HIS A 1 233 ? -22.378 -31.797 -32.871 1.00 24.25  ? 496  HIS A C   1 
ATOM   1486 O  O   . HIS A 1 233 ? -21.917 -32.321 -33.908 1.00 30.69  ? 496  HIS A O   1 
ATOM   1487 C  CB  . HIS A 1 233 ? -24.042 -33.700 -32.867 1.00 32.31  ? 496  HIS A CB  1 
ATOM   1488 C  CG  . HIS A 1 233 ? -25.174 -34.407 -32.213 1.00 39.90  ? 496  HIS A CG  1 
ATOM   1489 N  ND1 . HIS A 1 233 ? -25.032 -35.100 -31.044 1.00 42.39  ? 496  HIS A ND1 1 
ATOM   1490 C  CD2 . HIS A 1 233 ? -26.479 -34.517 -32.597 1.00 43.77  ? 496  HIS A CD2 1 
ATOM   1491 C  CE1 . HIS A 1 233 ? -26.201 -35.630 -30.713 1.00 46.70  ? 496  HIS A CE1 1 
ATOM   1492 N  NE2 . HIS A 1 233 ? -27.098 -35.293 -31.673 1.00 45.11  ? 496  HIS A NE2 1 
ATOM   1493 N  N   . TRP A 1 234 ? -21.945 -30.650 -32.400 1.00 25.34  ? 497  TRP A N   1 
ATOM   1494 C  CA  . TRP A 1 234 ? -20.885 -29.835 -33.038 1.00 27.28  ? 497  TRP A CA  1 
ATOM   1495 C  C   . TRP A 1 234 ? -19.545 -30.623 -33.117 1.00 27.21  ? 497  TRP A C   1 
ATOM   1496 O  O   . TRP A 1 234 ? -18.775 -30.447 -34.098 1.00 27.99  ? 497  TRP A O   1 
ATOM   1497 C  CB  . TRP A 1 234 ? -20.748 -28.472 -32.338 1.00 27.41  ? 497  TRP A CB  1 
ATOM   1498 C  CG  . TRP A 1 234 ? -21.755 -27.467 -32.816 1.00 33.36  ? 497  TRP A CG  1 
ATOM   1499 C  CD1 . TRP A 1 234 ? -23.119 -27.648 -32.855 1.00 29.96  ? 497  TRP A CD1 1 
ATOM   1500 C  CD2 . TRP A 1 234 ? -21.507 -26.152 -33.363 1.00 30.69  ? 497  TRP A CD2 1 
ATOM   1501 N  NE1 . TRP A 1 234 ? -23.726 -26.551 -33.414 1.00 33.77  ? 497  TRP A NE1 1 
ATOM   1502 C  CE2 . TRP A 1 234 ? -22.771 -25.614 -33.726 1.00 30.33  ? 497  TRP A CE2 1 
ATOM   1503 C  CE3 . TRP A 1 234 ? -20.369 -25.381 -33.618 1.00 32.25  ? 497  TRP A CE3 1 
ATOM   1504 C  CZ2 . TRP A 1 234 ? -22.913 -24.334 -34.273 1.00 31.99  ? 497  TRP A CZ2 1 
ATOM   1505 C  CZ3 . TRP A 1 234 ? -20.512 -24.128 -34.188 1.00 32.77  ? 497  TRP A CZ3 1 
ATOM   1506 C  CH2 . TRP A 1 234 ? -21.774 -23.606 -34.502 1.00 32.79  ? 497  TRP A CH2 1 
ATOM   1507 N  N   . PHE A 1 235 ? -19.292 -31.485 -32.135 0.50 27.38  ? 498  PHE A N   1 
ATOM   1508 C  CA  . PHE A 1 235 ? -18.026 -32.253 -32.000 0.50 27.42  ? 498  PHE A CA  1 
ATOM   1509 C  C   . PHE A 1 235 ? -18.214 -33.698 -32.477 0.50 29.25  ? 498  PHE A C   1 
ATOM   1510 O  O   . PHE A 1 235 ? -17.400 -34.550 -32.058 0.50 28.72  ? 498  PHE A O   1 
ATOM   1511 C  CB  . PHE A 1 235 ? -17.533 -32.122 -30.559 0.50 26.29  ? 498  PHE A CB  1 
ATOM   1512 C  CG  . PHE A 1 235 ? -17.227 -30.698 -30.167 0.50 28.32  ? 498  PHE A CG  1 
ATOM   1513 C  CD1 . PHE A 1 235 ? -16.154 -30.025 -30.735 0.50 28.16  ? 498  PHE A CD1 1 
ATOM   1514 C  CD2 . PHE A 1 235 ? -18.024 -30.017 -29.263 0.50 27.80  ? 498  PHE A CD2 1 
ATOM   1515 C  CE1 . PHE A 1 235 ? -15.877 -28.709 -30.401 0.50 28.45  ? 498  PHE A CE1 1 
ATOM   1516 C  CE2 . PHE A 1 235 ? -17.739 -28.701 -28.926 0.50 31.02  ? 498  PHE A CE2 1 
ATOM   1517 C  CZ  . PHE A 1 235 ? -16.671 -28.046 -29.499 0.50 30.57  ? 498  PHE A CZ  1 
ATOM   1518 N  N   . SER A 1 236 ? -19.196 -33.966 -33.355 0.50 27.30  ? 499  SER A N   1 
ATOM   1519 C  CA  . SER A 1 236 ? -19.311 -35.262 -34.080 0.50 26.72  ? 499  SER A CA  1 
ATOM   1520 C  C   . SER A 1 236 ? -18.145 -35.381 -35.073 0.50 25.66  ? 499  SER A C   1 
ATOM   1521 O  O   . SER A 1 236 ? -17.693 -34.356 -35.582 0.50 25.30  ? 499  SER A O   1 
ATOM   1522 C  CB  . SER A 1 236 ? -20.632 -35.407 -34.804 0.50 27.21  ? 499  SER A CB  1 
ATOM   1523 O  OG  . SER A 1 236 ? -20.543 -34.910 -36.135 0.50 25.34  ? 499  SER A OG  1 
ATOM   1524 N  N   . ARG A 1 237 ? -17.678 -36.594 -35.346 0.50 25.66  ? 500  ARG A N   1 
ATOM   1525 C  CA  . ARG A 1 237 ? -16.595 -36.812 -36.327 0.50 26.78  ? 500  ARG A CA  1 
ATOM   1526 C  C   . ARG A 1 237 ? -17.028 -36.239 -37.680 0.50 27.46  ? 500  ARG A C   1 
ATOM   1527 O  O   . ARG A 1 237 ? -16.136 -35.775 -38.432 0.50 23.79  ? 500  ARG A O   1 
ATOM   1528 C  CB  . ARG A 1 237 ? -16.212 -38.287 -36.407 0.50 28.08  ? 500  ARG A CB  1 
ATOM   1529 C  CG  . ARG A 1 237 ? -14.845 -38.500 -37.034 0.50 26.98  ? 500  ARG A CG  1 
ATOM   1530 C  CD  . ARG A 1 237 ? -14.084 -39.675 -36.447 0.50 27.36  ? 500  ARG A CD  1 
ATOM   1531 N  NE  . ARG A 1 237 ? -12.677 -39.600 -36.800 0.50 25.66  ? 500  ARG A NE  1 
ATOM   1532 C  CZ  . ARG A 1 237 ? -11.762 -38.918 -36.113 0.50 24.82  ? 500  ARG A CZ  1 
ATOM   1533 N  NH1 . ARG A 1 237 ? -12.105 -38.243 -35.029 0.50 23.36  ? 500  ARG A NH1 1 
ATOM   1534 N  NH2 . ARG A 1 237 ? -10.508 -38.910 -36.521 0.50 25.29  ? 500  ARG A NH2 1 
ATOM   1535 N  N   . GLU A 1 238 ? -18.342 -36.229 -37.943 0.50 27.95  ? 501  GLU A N   1 
ATOM   1536 C  CA  . GLU A 1 238 ? -18.950 -35.667 -39.176 0.50 27.80  ? 501  GLU A CA  1 
ATOM   1537 C  C   . GLU A 1 238 ? -18.761 -34.144 -39.195 0.50 25.43  ? 501  GLU A C   1 
ATOM   1538 O  O   . GLU A 1 238 ? -18.304 -33.634 -40.212 0.50 27.69  ? 501  GLU A O   1 
ATOM   1539 C  CB  . GLU A 1 238 ? -20.431 -36.045 -39.267 0.50 30.71  ? 501  GLU A CB  1 
ATOM   1540 C  CG  . GLU A 1 238 ? -21.117 -35.498 -40.508 0.50 34.71  ? 501  GLU A CG  1 
ATOM   1541 C  CD  . GLU A 1 238 ? -22.459 -36.164 -40.784 0.50 39.96  ? 501  GLU A CD  1 
ATOM   1542 O  OE1 . GLU A 1 238 ? -22.722 -36.515 -41.968 0.50 42.34  ? 501  GLU A OE1 1 
ATOM   1543 O  OE2 . GLU A 1 238 ? -23.226 -36.361 -39.813 0.50 41.28  ? 501  GLU A OE2 1 
ATOM   1544 N  N   . ASN A 1 239 ? -19.057 -33.439 -38.101 0.50 24.66  ? 502  ASN A N   1 
ATOM   1545 C  CA  . ASN A 1 239 ? -18.963 -31.956 -38.090 0.50 25.02  ? 502  ASN A CA  1 
ATOM   1546 C  C   . ASN A 1 239 ? -17.536 -31.459 -37.799 0.50 25.57  ? 502  ASN A C   1 
ATOM   1547 O  O   . ASN A 1 239 ? -17.244 -30.332 -38.235 0.50 24.11  ? 502  ASN A O   1 
ATOM   1548 C  CB  . ASN A 1 239 ? -19.915 -31.268 -37.109 0.50 24.99  ? 502  ASN A CB  1 
ATOM   1549 C  CG  . ASN A 1 239 ? -19.970 -29.785 -37.410 0.50 25.68  ? 502  ASN A CG  1 
ATOM   1550 O  OD1 . ASN A 1 239 ? -20.313 -29.409 -38.535 0.50 25.79  ? 502  ASN A OD1 1 
ATOM   1551 N  ND2 . ASN A 1 239 ? -19.629 -28.940 -36.443 0.50 22.61  ? 502  ASN A ND2 1 
ATOM   1552 N  N   . SER A 1 240 ? -16.695 -32.249 -37.107 0.50 26.11  ? 503  SER A N   1 
ATOM   1553 C  CA  . SER A 1 240 ? -15.371 -31.825 -36.557 0.50 25.80  ? 503  SER A CA  1 
ATOM   1554 C  C   . SER A 1 240 ? -14.191 -32.594 -37.190 0.50 23.47  ? 503  SER A C   1 
ATOM   1555 O  O   . SER A 1 240 ? -13.106 -32.019 -37.219 0.50 24.58  ? 503  SER A O   1 
ATOM   1556 C  CB  . SER A 1 240 ? -15.335 -31.960 -35.053 0.50 26.13  ? 503  SER A CB  1 
ATOM   1557 O  OG  . SER A 1 240 ? -15.476 -33.324 -34.657 0.50 23.88  ? 503  SER A OG  1 
ATOM   1558 N  N   . LEU A 1 241 ? -14.396 -33.822 -37.681 0.50 24.35  ? 504  LEU A N   1 
ATOM   1559 C  CA  . LEU A 1 241 ? -13.356 -34.720 -38.275 0.50 23.41  ? 504  LEU A CA  1 
ATOM   1560 C  C   . LEU A 1 241 ? -12.459 -35.317 -37.174 0.50 23.61  ? 504  LEU A C   1 
ATOM   1561 O  O   . LEU A 1 241 ? -12.175 -36.535 -37.257 0.50 23.13  ? 504  LEU A O   1 
ATOM   1562 C  CB  . LEU A 1 241 ? -12.522 -33.939 -39.305 0.50 24.33  ? 504  LEU A CB  1 
ATOM   1563 C  CG  . LEU A 1 241 ? -13.327 -33.173 -40.355 0.50 25.82  ? 504  LEU A CG  1 
ATOM   1564 C  CD1 . LEU A 1 241 ? -12.449 -32.181 -41.133 0.50 26.76  ? 504  LEU A CD1 1 
ATOM   1565 C  CD2 . LEU A 1 241 ? -14.016 -34.134 -41.299 0.50 25.28  ? 504  LEU A CD2 1 
ATOM   1566 N  N   . SER A 1 242 ? -11.992 -34.503 -36.218 0.50 21.45  ? 505  SER A N   1 
ATOM   1567 C  CA  . SER A 1 242 ? -11.138 -34.926 -35.070 0.50 22.92  ? 505  SER A CA  1 
ATOM   1568 C  C   . SER A 1 242 ? -12.000 -35.409 -33.907 0.50 22.21  ? 505  SER A C   1 
ATOM   1569 O  O   . SER A 1 242 ? -11.481 -36.056 -32.974 0.50 21.08  ? 505  SER A O   1 
ATOM   1570 C  CB  . SER A 1 242 ? -10.255 -33.800 -34.589 0.50 22.96  ? 505  SER A CB  1 
ATOM   1571 O  OG  . SER A 1 242 ? -9.335  -33.423 -35.582 0.50 23.30  ? 505  SER A OG  1 
ATOM   1572 N  N   . GLY A 1 243 ? -13.271 -35.016 -33.905 0.50 22.45  ? 506  GLY A N   1 
ATOM   1573 C  CA  . GLY A 1 243 ? -14.175 -35.299 -32.786 0.50 20.67  ? 506  GLY A CA  1 
ATOM   1574 C  C   . GLY A 1 243 ? -14.664 -36.729 -32.808 0.50 21.01  ? 506  GLY A C   1 
ATOM   1575 O  O   . GLY A 1 243 ? -14.635 -37.364 -33.888 0.50 21.72  ? 506  GLY A O   1 
ATOM   1576 N  N   . VAL A 1 244 ? -15.070 -37.213 -31.634 0.50 22.48  ? 507  VAL A N   1 
ATOM   1577 C  CA  . VAL A 1 244 ? -15.732 -38.537 -31.464 0.50 23.09  ? 507  VAL A CA  1 
ATOM   1578 C  C   . VAL A 1 244 ? -16.978 -38.375 -30.580 0.50 23.48  ? 507  VAL A C   1 
ATOM   1579 O  O   . VAL A 1 244 ? -17.300 -39.323 -29.820 0.50 23.11  ? 507  VAL A O   1 
ATOM   1580 C  CB  . VAL A 1 244 ? -14.751 -39.579 -30.881 0.50 21.48  ? 507  VAL A CB  1 
ATOM   1581 C  CG1 . VAL A 1 244 ? -13.602 -39.872 -31.828 0.50 21.75  ? 507  VAL A CG1 1 
ATOM   1582 C  CG2 . VAL A 1 244 ? -14.232 -39.172 -29.513 0.50 22.16  ? 507  VAL A CG2 1 
ATOM   1583 N  N   . GLU A 1 245 ? -17.688 -37.245 -30.658 0.50 23.76  ? 508  GLU A N   1 
ATOM   1584 C  CA  . GLU A 1 245 ? -18.978 -37.115 -29.912 0.50 25.01  ? 508  GLU A CA  1 
ATOM   1585 C  C   . GLU A 1 245 ? -20.006 -38.067 -30.537 0.50 23.37  ? 508  GLU A C   1 
ATOM   1586 O  O   . GLU A 1 245 ? -20.099 -38.131 -31.772 0.50 22.02  ? 508  GLU A O   1 
ATOM   1587 C  CB  . GLU A 1 245 ? -19.506 -35.681 -29.888 0.50 25.61  ? 508  GLU A CB  1 
ATOM   1588 C  CG  . GLU A 1 245 ? -20.819 -35.540 -29.135 0.50 29.09  ? 508  GLU A CG  1 
ATOM   1589 C  CD  . GLU A 1 245 ? -22.072 -35.718 -29.981 0.50 30.12  ? 508  GLU A CD  1 
ATOM   1590 O  OE1 . GLU A 1 245 ? -22.005 -35.516 -31.208 0.50 35.77  ? 508  GLU A OE1 1 
ATOM   1591 O  OE2 . GLU A 1 245 ? -23.119 -36.024 -29.413 0.50 35.53  ? 508  GLU A OE2 1 
ATOM   1592 N  N   . GLY A 1 246 ? -20.729 -38.801 -29.702 0.50 23.72  ? 509  GLY A N   1 
ATOM   1593 C  CA  . GLY A 1 246 ? -21.797 -39.727 -30.130 0.50 23.43  ? 509  GLY A CA  1 
ATOM   1594 C  C   . GLY A 1 246 ? -21.245 -41.057 -30.608 0.50 26.03  ? 509  GLY A C   1 
ATOM   1595 O  O   . GLY A 1 246 ? -22.048 -41.877 -31.112 0.50 25.62  ? 509  GLY A O   1 
ATOM   1596 N  N   . GLU A 1 247 ? -19.936 -41.302 -30.449 0.50 27.85  ? 510  GLU A N   1 
ATOM   1597 C  CA  . GLU A 1 247 ? -19.302 -42.516 -31.030 0.50 28.80  ? 510  GLU A CA  1 
ATOM   1598 C  C   . GLU A 1 247 ? -19.553 -43.727 -30.130 0.50 31.66  ? 510  GLU A C   1 
ATOM   1599 O  O   . GLU A 1 247 ? -20.274 -44.633 -30.591 0.50 38.98  ? 510  GLU A O   1 
ATOM   1600 C  CB  . GLU A 1 247 ? -17.826 -42.290 -31.355 0.50 27.69  ? 510  GLU A CB  1 
ATOM   1601 C  CG  . GLU A 1 247 ? -17.642 -41.546 -32.669 0.50 27.58  ? 510  GLU A CG  1 
ATOM   1602 C  CD  . GLU A 1 247 ? -18.383 -42.113 -33.871 0.50 28.94  ? 510  GLU A CD  1 
ATOM   1603 O  OE1 . GLU A 1 247 ? -18.802 -43.279 -33.820 0.50 31.36  ? 510  GLU A OE1 1 
ATOM   1604 O  OE2 . GLU A 1 247 ? -18.543 -41.381 -34.865 0.50 28.74  ? 510  GLU A OE2 1 
ATOM   1605 N  N   . GLY A 1 248 ? -18.976 -43.790 -28.930 0.50 32.40  ? 511  GLY A N   1 
ATOM   1606 C  CA  . GLY A 1 248 ? -19.073 -45.028 -28.121 0.50 32.63  ? 511  GLY A CA  1 
ATOM   1607 C  C   . GLY A 1 248 ? -17.946 -46.012 -28.423 0.50 28.80  ? 511  GLY A C   1 
ATOM   1608 O  O   . GLY A 1 248 ? -17.213 -45.787 -29.393 0.50 27.73  ? 511  GLY A O   1 
ATOM   1609 N  N   A LEU A 1 249 ? -17.867 -47.099 -27.652 0.25 28.69  ? 512  LEU A N   1 
ATOM   1610 N  N   B LEU A 1 249 ? -17.763 -47.064 -27.604 0.25 27.50  ? 512  LEU A N   1 
ATOM   1611 C  CA  A LEU A 1 249 ? -16.656 -47.946 -27.479 0.25 28.41  ? 512  LEU A CA  1 
ATOM   1612 C  CA  B LEU A 1 249 ? -16.523 -47.895 -27.565 0.25 26.91  ? 512  LEU A CA  1 
ATOM   1613 C  C   A LEU A 1 249 ? -16.489 -48.935 -28.637 0.25 29.15  ? 512  LEU A C   1 
ATOM   1614 C  C   B LEU A 1 249 ? -16.440 -48.848 -28.761 0.25 28.42  ? 512  LEU A C   1 
ATOM   1615 O  O   A LEU A 1 249 ? -15.340 -49.315 -28.912 0.25 27.56  ? 512  LEU A O   1 
ATOM   1616 O  O   B LEU A 1 249 ? -15.302 -49.138 -29.170 0.25 27.54  ? 512  LEU A O   1 
ATOM   1617 C  CB  A LEU A 1 249 ? -16.788 -48.686 -26.147 0.25 30.59  ? 512  LEU A CB  1 
ATOM   1618 C  CB  B LEU A 1 249 ? -16.450 -48.692 -26.259 0.25 27.42  ? 512  LEU A CB  1 
ATOM   1619 C  CG  A LEU A 1 249 ? -15.585 -48.600 -25.219 0.25 29.26  ? 512  LEU A CG  1 
ATOM   1620 C  CG  B LEU A 1 249 ? -15.883 -47.946 -25.057 0.25 25.84  ? 512  LEU A CG  1 
ATOM   1621 C  CD1 A LEU A 1 249 ? -14.955 -47.214 -25.255 0.25 30.79  ? 512  LEU A CD1 1 
ATOM   1622 C  CD1 B LEU A 1 249 ? -16.124 -48.736 -23.780 0.25 25.87  ? 512  LEU A CD1 1 
ATOM   1623 C  CD2 A LEU A 1 249 ? -15.984 -48.981 -23.805 0.25 29.22  ? 512  LEU A CD2 1 
ATOM   1624 C  CD2 B LEU A 1 249 ? -14.394 -47.651 -25.238 0.25 25.91  ? 512  LEU A CD2 1 
ATOM   1625 N  N   . HIS A 1 250 ? -17.591 -49.339 -29.272 0.50 27.43  ? 513  HIS A N   1 
ATOM   1626 C  CA  . HIS A 1 250 ? -17.635 -50.246 -30.452 0.50 27.54  ? 513  HIS A CA  1 
ATOM   1627 C  C   . HIS A 1 250 ? -17.193 -49.494 -31.710 0.50 26.41  ? 513  HIS A C   1 
ATOM   1628 O  O   . HIS A 1 250 ? -17.109 -50.132 -32.796 0.50 25.62  ? 513  HIS A O   1 
ATOM   1629 C  CB  . HIS A 1 250 ? -19.053 -50.801 -30.629 0.50 28.31  ? 513  HIS A CB  1 
ATOM   1630 C  CG  . HIS A 1 250 ? -20.071 -49.714 -30.634 0.50 29.46  ? 513  HIS A CG  1 
ATOM   1631 N  ND1 . HIS A 1 250 ? -20.898 -49.474 -31.723 0.50 32.52  ? 513  HIS A ND1 1 
ATOM   1632 C  CD2 . HIS A 1 250 ? -20.368 -48.781 -29.707 0.50 29.46  ? 513  HIS A CD2 1 
ATOM   1633 C  CE1 . HIS A 1 250 ? -21.680 -48.447 -31.448 0.50 31.10  ? 513  HIS A CE1 1 
ATOM   1634 N  NE2 . HIS A 1 250 ? -21.367 -48.000 -30.218 0.50 31.80  ? 513  HIS A NE2 1 
ATOM   1635 N  N   . LYS A 1 251 ? -16.927 -48.194 -31.563 0.50 25.62  ? 514  LYS A N   1 
ATOM   1636 C  CA  . LYS A 1 251 ? -16.499 -47.295 -32.667 0.50 27.21  ? 514  LYS A CA  1 
ATOM   1637 C  C   . LYS A 1 251 ? -15.044 -46.839 -32.502 0.50 25.95  ? 514  LYS A C   1 
ATOM   1638 O  O   . LYS A 1 251 ? -14.302 -46.836 -33.524 0.50 26.63  ? 514  LYS A O   1 
ATOM   1639 C  CB  . LYS A 1 251 ? -17.420 -46.074 -32.690 0.50 29.86  ? 514  LYS A CB  1 
ATOM   1640 C  CG  . LYS A 1 251 ? -18.885 -46.447 -32.862 0.50 33.93  ? 514  LYS A CG  1 
ATOM   1641 C  CD  . LYS A 1 251 ? -19.083 -47.275 -34.089 0.50 33.70  ? 514  LYS A CD  1 
ATOM   1642 C  CE  . LYS A 1 251 ? -19.592 -46.433 -35.238 0.50 36.84  ? 514  LYS A CE  1 
ATOM   1643 N  NZ  . LYS A 1 251 ? -20.894 -45.830 -34.881 0.50 37.66  ? 514  LYS A NZ  1 
ATOM   1644 N  N   . LEU A 1 252 ? -14.664 -46.435 -31.288 1.00 23.29  ? 515  LEU A N   1 
ATOM   1645 C  CA  . LEU A 1 252 ? -13.376 -45.740 -31.042 1.00 23.94  ? 515  LEU A CA  1 
ATOM   1646 C  C   . LEU A 1 252 ? -12.163 -46.507 -31.624 1.00 23.13  ? 515  LEU A C   1 
ATOM   1647 O  O   . LEU A 1 252 ? -11.258 -45.850 -32.189 1.00 21.91  ? 515  LEU A O   1 
ATOM   1648 C  CB  . LEU A 1 252 ? -13.211 -45.479 -29.560 1.00 25.50  ? 515  LEU A CB  1 
ATOM   1649 C  CG  . LEU A 1 252 ? -14.233 -44.553 -28.923 1.00 25.18  ? 515  LEU A CG  1 
ATOM   1650 C  CD1 . LEU A 1 252 ? -13.826 -44.222 -27.502 1.00 26.93  ? 515  LEU A CD1 1 
ATOM   1651 C  CD2 . LEU A 1 252 ? -14.425 -43.275 -29.713 1.00 25.28  ? 515  LEU A CD2 1 
ATOM   1652 N  N   . GLY A 1 253 ? -12.130 -47.832 -31.535 1.00 22.82  ? 516  GLY A N   1 
ATOM   1653 C  CA  . GLY A 1 253 ? -11.004 -48.579 -32.075 1.00 22.15  ? 516  GLY A CA  1 
ATOM   1654 C  C   . GLY A 1 253 ? -11.011 -48.528 -33.584 1.00 24.66  ? 516  GLY A C   1 
ATOM   1655 O  O   . GLY A 1 253 ? -9.894  -48.344 -34.174 1.00 23.85  ? 516  GLY A O   1 
ATOM   1656 N  N   . TYR A 1 254 ? -12.192 -48.674 -34.211 1.00 24.85  ? 517  TYR A N   1 
ATOM   1657 C  CA  . TYR A 1 254 ? -12.258 -48.521 -35.683 1.00 24.62  ? 517  TYR A CA  1 
ATOM   1658 C  C   . TYR A 1 254 ? -11.719 -47.139 -36.086 1.00 22.15  ? 517  TYR A C   1 
ATOM   1659 O  O   . TYR A 1 254 ? -11.026 -46.978 -37.145 1.00 25.53  ? 517  TYR A O   1 
ATOM   1660 C  CB  . TYR A 1 254 ? -13.667 -48.745 -36.206 1.00 24.53  ? 517  TYR A CB  1 
ATOM   1661 C  CG  . TYR A 1 254 ? -14.099 -50.190 -36.245 1.00 22.28  ? 517  TYR A CG  1 
ATOM   1662 C  CD1 . TYR A 1 254 ? -13.558 -51.095 -37.160 1.00 25.65  ? 517  TYR A CD1 1 
ATOM   1663 C  CD2 . TYR A 1 254 ? -15.042 -50.647 -35.344 1.00 24.70  ? 517  TYR A CD2 1 
ATOM   1664 C  CE1 . TYR A 1 254 ? -14.006 -52.415 -37.224 1.00 25.13  ? 517  TYR A CE1 1 
ATOM   1665 C  CE2 . TYR A 1 254 ? -15.474 -51.959 -35.382 1.00 23.10  ? 517  TYR A CE2 1 
ATOM   1666 C  CZ  . TYR A 1 254 ? -14.967 -52.844 -36.313 1.00 24.39  ? 517  TYR A CZ  1 
ATOM   1667 O  OH  . TYR A 1 254 ? -15.493 -54.126 -36.253 1.00 26.41  ? 517  TYR A OH  1 
ATOM   1668 N  N   . ILE A 1 255 ? -12.066 -46.130 -35.330 1.00 24.51  ? 518  ILE A N   1 
ATOM   1669 C  CA  . ILE A 1 255 ? -11.656 -44.759 -35.677 1.00 24.98  ? 518  ILE A CA  1 
ATOM   1670 C  C   . ILE A 1 255 ? -10.120 -44.671 -35.582 1.00 26.57  ? 518  ILE A C   1 
ATOM   1671 O  O   . ILE A 1 255 ? -9.490  -44.080 -36.500 1.00 26.56  ? 518  ILE A O   1 
ATOM   1672 C  CB  . ILE A 1 255 ? -12.389 -43.746 -34.796 1.00 25.37  ? 518  ILE A CB  1 
ATOM   1673 C  CG1 . ILE A 1 255 ? -13.861 -43.623 -35.202 1.00 23.90  ? 518  ILE A CG1 1 
ATOM   1674 C  CG2 . ILE A 1 255 ? -11.707 -42.389 -34.755 1.00 26.12  ? 518  ILE A CG2 1 
ATOM   1675 C  CD1 . ILE A 1 255 ? -14.709 -42.928 -34.134 1.00 28.83  ? 518  ILE A CD1 1 
ATOM   1676 N  N   . LEU A 1 256 ? -9.500  -45.203 -34.514 1.00 24.65  ? 519  LEU A N   1 
ATOM   1677 C  CA  . LEU A 1 256 ? -8.017  -45.157 -34.391 1.00 25.61  ? 519  LEU A CA  1 
ATOM   1678 C  C   . LEU A 1 256 ? -7.371  -45.966 -35.521 1.00 27.50  ? 519  LEU A C   1 
ATOM   1679 O  O   . LEU A 1 256 ? -6.269  -45.543 -36.049 1.00 28.61  ? 519  LEU A O   1 
ATOM   1680 C  CB  . LEU A 1 256 ? -7.590  -45.723 -33.038 1.00 27.58  ? 519  LEU A CB  1 
ATOM   1681 C  CG  . LEU A 1 256 ? -7.956  -44.908 -31.822 1.00 28.80  ? 519  LEU A CG  1 
ATOM   1682 C  CD1 . LEU A 1 256 ? -7.354  -45.602 -30.589 1.00 31.71  ? 519  LEU A CD1 1 
ATOM   1683 C  CD2 . LEU A 1 256 ? -7.433  -43.478 -31.921 1.00 29.55  ? 519  LEU A CD2 1 
ATOM   1684 N  N   . ARG A 1 257 ? -7.980  -47.084 -35.922 1.00 27.12  ? 520  ARG A N   1 
ATOM   1685 C  CA  . ARG A 1 257 ? -7.386  -47.892 -37.016 1.00 28.07  ? 520  ARG A CA  1 
ATOM   1686 C  C   . ARG A 1 257 ? -7.461  -47.057 -38.312 1.00 29.22  ? 520  ARG A C   1 
ATOM   1687 O  O   . ARG A 1 257 ? -6.497  -47.096 -39.122 1.00 27.74  ? 520  ARG A O   1 
ATOM   1688 C  CB  . ARG A 1 257 ? -8.030  -49.276 -37.123 1.00 27.01  ? 520  ARG A CB  1 
ATOM   1689 C  CG  . ARG A 1 257 ? -7.489  -50.126 -38.274 1.00 29.76  ? 520  ARG A CG  1 
ATOM   1690 C  CD  . ARG A 1 257 ? -8.241  -51.432 -38.437 1.00 27.91  ? 520  ARG A CD  1 
ATOM   1691 N  NE  . ARG A 1 257 ? -9.562  -51.295 -39.027 1.00 26.92  ? 520  ARG A NE  1 
ATOM   1692 C  CZ  . ARG A 1 257 ? -10.335 -52.309 -39.429 1.00 25.54  ? 520  ARG A CZ  1 
ATOM   1693 N  NH1 . ARG A 1 257 ? -9.983  -53.562 -39.244 1.00 29.02  ? 520  ARG A NH1 1 
ATOM   1694 N  NH2 . ARG A 1 257 ? -11.453 -52.036 -40.009 1.00 28.27  ? 520  ARG A NH2 1 
ATOM   1695 N  N   . ASP A 1 258 ? -8.522  -46.302 -38.505 1.00 26.10  ? 521  ASP A N   1 
ATOM   1696 C  CA  . ASP A 1 258 ? -8.637  -45.423 -39.726 1.00 27.54  ? 521  ASP A CA  1 
ATOM   1697 C  C   . ASP A 1 258 ? -7.540  -44.322 -39.704 1.00 28.23  ? 521  ASP A C   1 
ATOM   1698 O  O   . ASP A 1 258 ? -6.936  -44.105 -40.719 1.00 31.01  ? 521  ASP A O   1 
ATOM   1699 C  CB  . ASP A 1 258 ? -10.040 -44.843 -39.906 1.00 28.21  ? 521  ASP A CB  1 
ATOM   1700 C  CG  . ASP A 1 258 ? -11.030 -45.772 -40.590 1.00 29.46  ? 521  ASP A CG  1 
ATOM   1701 O  OD1 . ASP A 1 258 ? -10.631 -46.855 -41.023 1.00 29.92  ? 521  ASP A OD1 1 
ATOM   1702 O  OD2 . ASP A 1 258 ? -12.203 -45.413 -40.597 1.00 33.33  ? 521  ASP A OD2 1 
ATOM   1703 N  N   . VAL A 1 259 ? -7.287  -43.657 -38.590 1.00 25.87  ? 522  VAL A N   1 
ATOM   1704 C  CA  . VAL A 1 259 ? -6.190  -42.667 -38.389 1.00 28.51  ? 522  VAL A CA  1 
ATOM   1705 C  C   . VAL A 1 259 ? -4.856  -43.374 -38.709 1.00 31.77  ? 522  VAL A C   1 
ATOM   1706 O  O   . VAL A 1 259 ? -4.062  -42.832 -39.454 1.00 32.60  ? 522  VAL A O   1 
ATOM   1707 C  CB  . VAL A 1 259 ? -6.177  -42.099 -36.959 1.00 31.69  ? 522  VAL A CB  1 
ATOM   1708 C  CG1 . VAL A 1 259 ? -4.902  -41.288 -36.703 1.00 32.11  ? 522  VAL A CG1 1 
ATOM   1709 C  CG2 . VAL A 1 259 ? -7.413  -41.236 -36.668 1.00 30.28  ? 522  VAL A CG2 1 
ATOM   1710 N  N   . SER A 1 260 ? -4.691  -44.629 -38.302 1.00 29.44  ? 523  SER A N   1 
ATOM   1711 C  CA  . SER A 1 260 ? -3.445  -45.397 -38.526 1.00 31.67  ? 523  SER A CA  1 
ATOM   1712 C  C   . SER A 1 260 ? -3.160  -45.585 -40.020 1.00 33.88  ? 523  SER A C   1 
ATOM   1713 O  O   . SER A 1 260 ? -1.998  -45.740 -40.360 1.00 32.22  ? 523  SER A O   1 
ATOM   1714 C  CB  . SER A 1 260 ? -3.414  -46.706 -37.822 1.00 27.55  ? 523  SER A CB  1 
ATOM   1715 O  OG  . SER A 1 260 ? -4.032  -47.728 -38.584 1.00 30.74  ? 523  SER A OG  1 
ATOM   1716 N  N   . LYS A 1 261 ? -4.197  -45.538 -40.863 0.50 34.79  ? 524  LYS A N   1 
ATOM   1717 C  CA  . LYS A 1 261 ? -4.117  -45.778 -42.329 0.50 35.62  ? 524  LYS A CA  1 
ATOM   1718 C  C   . LYS A 1 261 ? -3.442  -44.594 -43.030 0.50 35.55  ? 524  LYS A C   1 
ATOM   1719 O  O   . LYS A 1 261 ? -2.990  -44.765 -44.181 0.50 36.60  ? 524  LYS A O   1 
ATOM   1720 C  CB  . LYS A 1 261 ? -5.517  -45.993 -42.910 0.50 38.73  ? 524  LYS A CB  1 
ATOM   1721 C  CG  . LYS A 1 261 ? -6.128  -47.358 -42.625 0.50 43.16  ? 524  LYS A CG  1 
ATOM   1722 C  CD  . LYS A 1 261 ? -7.545  -47.499 -43.139 0.50 45.99  ? 524  LYS A CD  1 
ATOM   1723 C  CE  . LYS A 1 261 ? -8.056  -48.918 -43.041 0.50 48.08  ? 524  LYS A CE  1 
ATOM   1724 N  NZ  . LYS A 1 261 ? -9.417  -49.036 -43.612 0.50 53.02  ? 524  LYS A NZ  1 
ATOM   1725 N  N   . LYS A 1 262 ? -3.395  -43.434 -42.380 0.50 35.55  ? 525  LYS A N   1 
ATOM   1726 C  CA  . LYS A 1 262 ? -2.799  -42.203 -42.956 0.50 36.61  ? 525  LYS A CA  1 
ATOM   1727 C  C   . LYS A 1 262 ? -1.271  -42.326 -42.963 0.50 37.55  ? 525  LYS A C   1 
ATOM   1728 O  O   . LYS A 1 262 ? -0.676  -42.661 -41.916 0.50 33.59  ? 525  LYS A O   1 
ATOM   1729 C  CB  . LYS A 1 262 ? -3.252  -40.976 -42.171 0.50 36.44  ? 525  LYS A CB  1 
ATOM   1730 C  CG  . LYS A 1 262 ? -4.731  -40.651 -42.325 0.50 36.62  ? 525  LYS A CG  1 
ATOM   1731 C  CD  . LYS A 1 262 ? -5.091  -39.269 -41.827 0.50 37.48  ? 525  LYS A CD  1 
ATOM   1732 C  CE  . LYS A 1 262 ? -6.497  -38.863 -42.205 0.50 36.15  ? 525  LYS A CE  1 
ATOM   1733 N  NZ  . LYS A 1 262 ? -6.647  -38.723 -43.675 0.50 34.52  ? 525  LYS A NZ  1 
ATOM   1734 N  N   . GLU A 1 263 ? -0.644  -42.072 -44.111 0.50 36.65  ? 526  GLU A N   1 
ATOM   1735 C  CA  . GLU A 1 263 ? 0.836   -41.995 -44.164 0.50 37.70  ? 526  GLU A CA  1 
ATOM   1736 C  C   . GLU A 1 263 ? 1.262   -40.928 -43.154 0.50 36.61  ? 526  GLU A C   1 
ATOM   1737 O  O   . GLU A 1 263 ? 0.641   -39.853 -43.131 0.50 35.77  ? 526  GLU A O   1 
ATOM   1738 C  CB  . GLU A 1 263 ? 1.352   -41.688 -45.571 0.50 37.07  ? 526  GLU A CB  1 
ATOM   1739 C  CG  . GLU A 1 263 ? 1.099   -42.808 -46.565 0.50 37.94  ? 526  GLU A CG  1 
ATOM   1740 C  CD  . GLU A 1 263 ? 1.662   -44.177 -46.201 0.50 37.60  ? 526  GLU A CD  1 
ATOM   1741 O  OE1 . GLU A 1 263 ? 2.831   -44.254 -45.769 0.50 38.83  ? 526  GLU A OE1 1 
ATOM   1742 O  OE2 . GLU A 1 263 ? 0.935   -45.171 -46.376 0.50 36.54  ? 526  GLU A OE2 1 
ATOM   1743 N  N   . GLY A 1 264 ? 2.277   -41.238 -42.353 1.00 34.77  ? 527  GLY A N   1 
ATOM   1744 C  CA  . GLY A 1 264 ? 2.866   -40.274 -41.410 1.00 36.36  ? 527  GLY A CA  1 
ATOM   1745 C  C   . GLY A 1 264 ? 3.746   -40.935 -40.395 1.00 34.55  ? 527  GLY A C   1 
ATOM   1746 O  O   . GLY A 1 264 ? 4.248   -42.009 -40.649 1.00 32.91  ? 527  GLY A O   1 
ATOM   1747 N  N   . GLY A 1 265 ? 3.986   -40.262 -39.284 1.00 34.88  ? 528  GLY A N   1 
ATOM   1748 C  CA  . GLY A 1 265 ? 4.946   -40.784 -38.315 1.00 35.65  ? 528  GLY A CA  1 
ATOM   1749 C  C   . GLY A 1 265 ? 4.233   -41.615 -37.267 1.00 39.73  ? 528  GLY A C   1 
ATOM   1750 O  O   . GLY A 1 265 ? 3.193   -42.212 -37.615 1.00 37.28  ? 528  GLY A O   1 
ATOM   1751 N  N   . ALA A 1 266 ? 4.769   -41.651 -36.058 1.00 33.68  ? 529  ALA A N   1 
ATOM   1752 C  CA  . ALA A 1 266 ? 4.220   -42.451 -34.939 1.00 31.94  ? 529  ALA A CA  1 
ATOM   1753 C  C   . ALA A 1 266 ? 2.865   -41.868 -34.578 1.00 30.98  ? 529  ALA A C   1 
ATOM   1754 O  O   . ALA A 1 266 ? 2.530   -40.766 -35.006 1.00 27.15  ? 529  ALA A O   1 
ATOM   1755 C  CB  . ALA A 1 266 ? 5.104   -42.370 -33.750 1.00 30.51  ? 529  ALA A CB  1 
ATOM   1756 N  N   . MET A 1 267 ? 2.096   -42.591 -33.764 0.50 28.51  ? 530  MET A N   1 
ATOM   1757 C  CA  . MET A 1 267 ? 0.829   -42.069 -33.185 0.50 28.17  ? 530  MET A CA  1 
ATOM   1758 C  C   . MET A 1 267 ? 1.116   -41.544 -31.770 0.50 26.89  ? 530  MET A C   1 
ATOM   1759 O  O   . MET A 1 267 ? 1.540   -42.344 -30.919 0.50 29.63  ? 530  MET A O   1 
ATOM   1760 C  CB  . MET A 1 267 ? -0.252  -43.165 -33.226 0.50 27.44  ? 530  MET A CB  1 
ATOM   1761 C  CG  . MET A 1 267 ? -0.634  -43.541 -34.673 0.50 27.12  ? 530  MET A CG  1 
ATOM   1762 S  SD  . MET A 1 267 ? -1.925  -44.834 -34.906 0.50 29.23  ? 530  MET A SD  1 
ATOM   1763 C  CE  . MET A 1 267 ? -3.384  -43.884 -34.498 0.50 26.00  ? 530  MET A CE  1 
ATOM   1764 N  N   . TYR A 1 268 ? 0.923   -40.232 -31.538 1.00 25.84  ? 531  TYR A N   1 
ATOM   1765 C  CA  . TYR A 1 268 ? 1.223   -39.546 -30.265 1.00 24.98  ? 531  TYR A CA  1 
ATOM   1766 C  C   . TYR A 1 268 ? -0.051  -39.447 -29.424 1.00 25.42  ? 531  TYR A C   1 
ATOM   1767 O  O   . TYR A 1 268 ? -1.135  -39.042 -29.975 1.00 26.87  ? 531  TYR A O   1 
ATOM   1768 C  CB  . TYR A 1 268 ? 1.871   -38.176 -30.555 1.00 23.38  ? 531  TYR A CB  1 
ATOM   1769 C  CG  . TYR A 1 268 ? 3.201   -38.328 -31.253 1.00 26.79  ? 531  TYR A CG  1 
ATOM   1770 C  CD1 . TYR A 1 268 ? 3.280   -38.515 -32.623 1.00 25.25  ? 531  TYR A CD1 1 
ATOM   1771 C  CD2 . TYR A 1 268 ? 4.369   -38.493 -30.536 1.00 28.35  ? 531  TYR A CD2 1 
ATOM   1772 C  CE1 . TYR A 1 268 ? 4.489   -38.751 -33.266 1.00 29.83  ? 531  TYR A CE1 1 
ATOM   1773 C  CE2 . TYR A 1 268 ? 5.582   -38.730 -31.157 1.00 29.90  ? 531  TYR A CE2 1 
ATOM   1774 C  CZ  . TYR A 1 268 ? 5.659   -38.853 -32.521 1.00 32.58  ? 531  TYR A CZ  1 
ATOM   1775 O  OH  . TYR A 1 268 ? 6.879   -39.055 -33.125 1.00 30.56  ? 531  TYR A OH  1 
ATOM   1776 N  N   . ALA A 1 269 ? 0.058   -39.696 -28.121 1.00 25.97  ? 532  ALA A N   1 
ATOM   1777 C  CA  . ALA A 1 269 ? -1.079  -39.671 -27.175 1.00 28.84  ? 532  ALA A CA  1 
ATOM   1778 C  C   . ALA A 1 269 ? -0.613  -39.073 -25.878 1.00 29.71  ? 532  ALA A C   1 
ATOM   1779 O  O   . ALA A 1 269 ? -0.577  -39.763 -24.837 1.00 30.52  ? 532  ALA A O   1 
ATOM   1780 C  CB  . ALA A 1 269 ? -1.693  -41.053 -26.993 1.00 28.57  ? 532  ALA A CB  1 
ATOM   1781 N  N   . ASP A 1 270 ? -0.249  -37.813 -25.933 1.00 29.50  ? 533  ASP A N   1 
ATOM   1782 C  CA  . ASP A 1 270 ? 0.326   -37.173 -24.743 1.00 28.36  ? 533  ASP A CA  1 
ATOM   1783 C  C   . ASP A 1 270 ? -0.820  -36.670 -23.883 1.00 31.43  ? 533  ASP A C   1 
ATOM   1784 O  O   . ASP A 1 270 ? -1.639  -35.954 -24.377 1.00 33.16  ? 533  ASP A O   1 
ATOM   1785 C  CB  . ASP A 1 270 ? 1.222   -35.990 -25.138 1.00 31.37  ? 533  ASP A CB  1 
ATOM   1786 C  CG  . ASP A 1 270 ? 2.528   -36.362 -25.820 1.00 35.13  ? 533  ASP A CG  1 
ATOM   1787 O  OD1 . ASP A 1 270 ? 2.928   -37.548 -25.711 1.00 31.39  ? 533  ASP A OD1 1 
ATOM   1788 O  OD2 . ASP A 1 270 ? 3.101   -35.487 -26.502 1.00 31.83  ? 533  ASP A OD2 1 
ATOM   1789 N  N   . ASP A 1 271 ? -0.798  -36.982 -22.589 0.50 32.46  ? 534  ASP A N   1 
ATOM   1790 C  CA  . ASP A 1 271 ? -1.743  -36.430 -21.582 0.50 37.42  ? 534  ASP A CA  1 
ATOM   1791 C  C   . ASP A 1 271 ? -1.271  -35.036 -21.153 0.50 37.18  ? 534  ASP A C   1 
ATOM   1792 O  O   . ASP A 1 271 ? -0.054  -34.775 -21.201 0.50 36.98  ? 534  ASP A O   1 
ATOM   1793 C  CB  . ASP A 1 271 ? -1.858  -37.356 -20.372 0.50 39.69  ? 534  ASP A CB  1 
ATOM   1794 C  CG  . ASP A 1 271 ? -2.786  -38.532 -20.602 0.50 42.20  ? 534  ASP A CG  1 
ATOM   1795 O  OD1 . ASP A 1 271 ? -3.931  -38.299 -21.051 0.50 49.38  ? 534  ASP A OD1 1 
ATOM   1796 O  OD2 . ASP A 1 271 ? -2.355  -39.670 -20.347 0.50 46.24  ? 534  ASP A OD2 1 
ATOM   1797 N  N   . THR A 1 272 ? -2.211  -34.171 -20.763 0.50 36.88  ? 535  THR A N   1 
ATOM   1798 C  CA  . THR A 1 272 ? -1.933  -32.884 -20.080 0.50 36.70  ? 535  THR A CA  1 
ATOM   1799 C  C   . THR A 1 272 ? -2.215  -33.065 -18.589 0.50 37.34  ? 535  THR A C   1 
ATOM   1800 O  O   . THR A 1 272 ? -3.286  -33.586 -18.248 0.50 37.90  ? 535  THR A O   1 
ATOM   1801 C  CB  . THR A 1 272 ? -2.760  -31.734 -20.667 0.50 37.20  ? 535  THR A CB  1 
ATOM   1802 O  OG1 . THR A 1 272 ? -2.425  -31.585 -22.048 0.50 35.15  ? 535  THR A OG1 1 
ATOM   1803 C  CG2 . THR A 1 272 ? -2.526  -30.417 -19.961 0.50 36.90  ? 535  THR A CG2 1 
ATOM   1804 N  N   . ALA A 1 273 ? -1.285  -32.649 -17.732 0.50 39.64  ? 536  ALA A N   1 
ATOM   1805 C  CA  . ALA A 1 273 ? -1.484  -32.585 -16.268 0.50 38.53  ? 536  ALA A CA  1 
ATOM   1806 C  C   . ALA A 1 273 ? -2.552  -31.527 -15.954 0.50 35.93  ? 536  ALA A C   1 
ATOM   1807 O  O   . ALA A 1 273 ? -2.395  -30.368 -16.389 0.50 32.20  ? 536  ALA A O   1 
ATOM   1808 C  CB  . ALA A 1 273 ? -0.163  -32.297 -15.592 0.50 39.48  ? 536  ALA A CB  1 
ATOM   1809 N  N   . GLY A 1 274 ? -3.627  -31.932 -15.268 0.50 37.45  ? 537  GLY A N   1 
ATOM   1810 C  CA  . GLY A 1 274 ? -4.725  -31.049 -14.821 0.50 35.99  ? 537  GLY A CA  1 
ATOM   1811 C  C   . GLY A 1 274 ? -5.173  -30.067 -15.895 0.50 35.43  ? 537  GLY A C   1 
ATOM   1812 O  O   . GLY A 1 274 ? -5.190  -28.844 -15.610 0.50 36.53  ? 537  GLY A O   1 
ATOM   1813 N  N   . TRP A 1 275 ? -5.577  -30.571 -17.069 0.50 34.92  ? 538  TRP A N   1 
ATOM   1814 C  CA  . TRP A 1 275 ? -5.900  -29.759 -18.280 0.50 32.57  ? 538  TRP A CA  1 
ATOM   1815 C  C   . TRP A 1 275 ? -6.719  -28.508 -17.918 0.50 31.09  ? 538  TRP A C   1 
ATOM   1816 O  O   . TRP A 1 275 ? -6.354  -27.407 -18.393 0.50 31.99  ? 538  TRP A O   1 
ATOM   1817 C  CB  . TRP A 1 275 ? -6.618  -30.608 -19.340 0.50 31.72  ? 538  TRP A CB  1 
ATOM   1818 C  CG  . TRP A 1 275 ? -7.234  -29.795 -20.439 0.50 30.98  ? 538  TRP A CG  1 
ATOM   1819 C  CD1 . TRP A 1 275 ? -8.438  -29.156 -20.401 0.50 30.54  ? 538  TRP A CD1 1 
ATOM   1820 C  CD2 . TRP A 1 275 ? -6.690  -29.545 -21.747 0.50 29.59  ? 538  TRP A CD2 1 
ATOM   1821 N  NE1 . TRP A 1 275 ? -8.676  -28.526 -21.590 0.50 31.28  ? 538  TRP A NE1 1 
ATOM   1822 C  CE2 . TRP A 1 275 ? -7.616  -28.732 -22.430 0.50 30.35  ? 538  TRP A CE2 1 
ATOM   1823 C  CE3 . TRP A 1 275 ? -5.513  -29.912 -22.405 0.50 30.12  ? 538  TRP A CE3 1 
ATOM   1824 C  CZ2 . TRP A 1 275 ? -7.406  -28.293 -23.735 0.50 29.10  ? 538  TRP A CZ2 1 
ATOM   1825 C  CZ3 . TRP A 1 275 ? -5.299  -29.470 -23.691 0.50 30.79  ? 538  TRP A CZ3 1 
ATOM   1826 C  CH2 . TRP A 1 275 ? -6.232  -28.665 -24.345 0.50 31.95  ? 538  TRP A CH2 1 
ATOM   1827 N  N   . ASP A 1 276 ? -7.811  -28.674 -17.175 0.50 30.28  ? 539  ASP A N   1 
ATOM   1828 C  CA  . ASP A 1 276 ? -8.754  -27.587 -16.782 0.50 32.11  ? 539  ASP A CA  1 
ATOM   1829 C  C   . ASP A 1 276 ? -7.966  -26.480 -16.052 0.50 33.75  ? 539  ASP A C   1 
ATOM   1830 O  O   . ASP A 1 276 ? -8.220  -25.269 -16.323 0.50 27.91  ? 539  ASP A O   1 
ATOM   1831 C  CB  . ASP A 1 276 ? -9.923  -28.150 -15.959 0.50 32.35  ? 539  ASP A CB  1 
ATOM   1832 C  CG  . ASP A 1 276 ? -10.925 -28.998 -16.742 0.50 33.24  ? 539  ASP A CG  1 
ATOM   1833 O  OD1 . ASP A 1 276 ? -10.721 -29.210 -17.956 0.50 30.20  ? 539  ASP A OD1 1 
ATOM   1834 O  OD2 . ASP A 1 276 ? -11.908 -29.473 -16.125 0.50 36.46  ? 539  ASP A OD2 1 
ATOM   1835 N  N   . THR A 1 277 ? -7.022  -26.860 -15.181 0.50 36.70  ? 540  THR A N   1 
ATOM   1836 C  CA  . THR A 1 277 ? -6.198  -25.906 -14.380 0.50 37.74  ? 540  THR A CA  1 
ATOM   1837 C  C   . THR A 1 277 ? -5.187  -25.215 -15.299 0.50 38.02  ? 540  THR A C   1 
ATOM   1838 O  O   . THR A 1 277 ? -4.559  -24.250 -14.847 0.50 38.80  ? 540  THR A O   1 
ATOM   1839 C  CB  . THR A 1 277 ? -5.509  -26.581 -13.183 0.50 38.31  ? 540  THR A CB  1 
ATOM   1840 O  OG1 . THR A 1 277 ? -4.753  -27.719 -13.605 0.50 40.86  ? 540  THR A OG1 1 
ATOM   1841 C  CG2 . THR A 1 277 ? -6.495  -27.013 -12.123 0.50 39.24  ? 540  THR A CG2 1 
ATOM   1842 N  N   . ARG A 1 278 ? -5.045  -25.684 -16.544 0.50 36.08  ? 541  ARG A N   1 
ATOM   1843 C  CA  . ARG A 1 278 ? -4.125  -25.088 -17.551 0.50 36.48  ? 541  ARG A CA  1 
ATOM   1844 C  C   . ARG A 1 278 ? -4.886  -24.168 -18.508 0.50 37.42  ? 541  ARG A C   1 
ATOM   1845 O  O   . ARG A 1 278 ? -4.222  -23.564 -19.369 0.50 34.80  ? 541  ARG A O   1 
ATOM   1846 C  CB  . ARG A 1 278 ? -3.438  -26.174 -18.387 0.50 39.18  ? 541  ARG A CB  1 
ATOM   1847 C  CG  . ARG A 1 278 ? -2.646  -27.186 -17.574 0.50 41.27  ? 541  ARG A CG  1 
ATOM   1848 C  CD  . ARG A 1 278 ? -1.559  -26.530 -16.745 0.50 42.37  ? 541  ARG A CD  1 
ATOM   1849 N  NE  . ARG A 1 278 ? -0.719  -27.541 -16.112 0.50 45.75  ? 541  ARG A NE  1 
ATOM   1850 C  CZ  . ARG A 1 278 ? 0.608   -27.529 -16.105 0.50 43.88  ? 541  ARG A CZ  1 
ATOM   1851 N  NH1 . ARG A 1 278 ? 1.267   -26.551 -16.704 0.50 45.96  ? 541  ARG A NH1 1 
ATOM   1852 N  NH2 . ARG A 1 278 ? 1.266   -28.488 -15.481 0.50 46.11  ? 541  ARG A NH2 1 
ATOM   1853 N  N   . ILE A 1 279 ? -6.221  -24.109 -18.407 0.50 36.71  ? 542  ILE A N   1 
ATOM   1854 C  CA  . ILE A 1 279 ? -7.069  -23.255 -19.287 0.50 37.19  ? 542  ILE A CA  1 
ATOM   1855 C  C   . ILE A 1 279 ? -6.790  -21.789 -18.934 0.50 37.35  ? 542  ILE A C   1 
ATOM   1856 O  O   . ILE A 1 279 ? -6.908  -21.432 -17.760 0.50 39.51  ? 542  ILE A O   1 
ATOM   1857 C  CB  . ILE A 1 279 ? -8.553  -23.647 -19.156 0.50 36.56  ? 542  ILE A CB  1 
ATOM   1858 C  CG1 . ILE A 1 279 ? -8.811  -24.993 -19.839 0.50 36.14  ? 542  ILE A CG1 1 
ATOM   1859 C  CG2 . ILE A 1 279 ? -9.469  -22.560 -19.707 0.50 36.21  ? 542  ILE A CG2 1 
ATOM   1860 C  CD1 . ILE A 1 279 ? -8.587  -24.964 -21.330 0.50 35.93  ? 542  ILE A CD1 1 
ATOM   1861 N  N   . THR A 1 280 ? -6.425  -20.992 -19.939 0.50 38.85  ? 543  THR A N   1 
ATOM   1862 C  CA  . THR A 1 280 ? -6.032  -19.580 -19.715 0.50 39.38  ? 543  THR A CA  1 
ATOM   1863 C  C   . THR A 1 280 ? -7.139  -18.624 -20.154 0.50 42.49  ? 543  THR A C   1 
ATOM   1864 O  O   . THR A 1 280 ? -8.076  -19.073 -20.833 0.50 36.97  ? 543  THR A O   1 
ATOM   1865 C  CB  . THR A 1 280 ? -4.778  -19.255 -20.535 0.50 37.32  ? 543  THR A CB  1 
ATOM   1866 O  OG1 . THR A 1 280 ? -5.105  -19.335 -21.923 0.50 37.53  ? 543  THR A OG1 1 
ATOM   1867 C  CG2 . THR A 1 280 ? -3.625  -20.183 -20.224 0.50 38.67  ? 543  THR A CG2 1 
ATOM   1868 N  N   . LEU A 1 281 ? -6.996  -17.341 -19.816 0.50 45.34  ? 544  LEU A N   1 
ATOM   1869 C  CA  . LEU A 1 281 ? -8.001  -16.326 -20.218 0.50 44.59  ? 544  LEU A CA  1 
ATOM   1870 C  C   . LEU A 1 281 ? -7.986  -16.167 -21.742 0.50 43.05  ? 544  LEU A C   1 
ATOM   1871 O  O   . LEU A 1 281 ? -9.055  -15.905 -22.309 0.50 43.14  ? 544  LEU A O   1 
ATOM   1872 C  CB  . LEU A 1 281 ? -7.665  -15.007 -19.520 0.50 52.95  ? 544  LEU A CB  1 
ATOM   1873 C  CG  . LEU A 1 281 ? -8.457  -13.791 -19.996 0.50 56.23  ? 544  LEU A CG  1 
ATOM   1874 C  CD1 . LEU A 1 281 ? -9.942  -13.961 -19.711 0.50 57.70  ? 544  LEU A CD1 1 
ATOM   1875 C  CD2 . LEU A 1 281 ? -7.928  -12.517 -19.358 0.50 57.25  ? 544  LEU A CD2 1 
ATOM   1876 N  N   . GLU A 1 282 ? -6.821  -16.326 -22.376 0.50 41.16  ? 545  GLU A N   1 
ATOM   1877 C  CA  . GLU A 1 282 ? -6.729  -16.236 -23.859 0.50 42.16  ? 545  GLU A CA  1 
ATOM   1878 C  C   . GLU A 1 282 ? -7.536  -17.370 -24.496 0.50 39.94  ? 545  GLU A C   1 
ATOM   1879 O  O   . GLU A 1 282 ? -8.202  -17.118 -25.514 0.50 38.54  ? 545  GLU A O   1 
ATOM   1880 C  CB  . GLU A 1 282 ? -5.268  -16.282 -24.296 0.50 46.67  ? 545  GLU A CB  1 
ATOM   1881 C  CG  . GLU A 1 282 ? -4.892  -15.141 -25.221 0.50 48.98  ? 545  GLU A CG  1 
ATOM   1882 C  CD  . GLU A 1 282 ? -5.213  -13.770 -24.655 0.50 51.50  ? 545  GLU A CD  1 
ATOM   1883 O  OE1 . GLU A 1 282 ? -5.009  -13.571 -23.442 0.50 55.52  ? 545  GLU A OE1 1 
ATOM   1884 O  OE2 . GLU A 1 282 ? -5.690  -12.915 -25.420 0.50 51.71  ? 545  GLU A OE2 1 
ATOM   1885 N  N   . ASP A 1 283 ? -7.440  -18.571 -23.935 0.50 36.31  ? 546  ASP A N   1 
ATOM   1886 C  CA  . ASP A 1 283 ? -8.220  -19.728 -24.445 0.50 34.73  ? 546  ASP A CA  1 
ATOM   1887 C  C   . ASP A 1 283 ? -9.701  -19.373 -24.369 0.50 35.33  ? 546  ASP A C   1 
ATOM   1888 O  O   . ASP A 1 283 ? -10.438 -19.655 -25.318 0.50 36.38  ? 546  ASP A O   1 
ATOM   1889 C  CB  . ASP A 1 283 ? -7.947  -20.961 -23.585 0.50 31.84  ? 546  ASP A CB  1 
ATOM   1890 C  CG  . ASP A 1 283 ? -6.561  -21.557 -23.755 0.50 29.73  ? 546  ASP A CG  1 
ATOM   1891 O  OD1 . ASP A 1 283 ? -6.004  -21.437 -24.858 0.50 24.17  ? 546  ASP A OD1 1 
ATOM   1892 O  OD2 . ASP A 1 283 ? -6.057  -22.142 -22.781 0.50 25.40  ? 546  ASP A OD2 1 
ATOM   1893 N  N   . LEU A 1 284 ? -10.092 -18.757 -23.266 0.50 36.11  ? 547  LEU A N   1 
ATOM   1894 C  CA  . LEU A 1 284 ? -11.513 -18.385 -23.006 0.50 36.30  ? 547  LEU A CA  1 
ATOM   1895 C  C   . LEU A 1 284 ? -11.972 -17.339 -24.026 0.50 36.52  ? 547  LEU A C   1 
ATOM   1896 O  O   . LEU A 1 284 ? -13.077 -17.511 -24.575 0.50 36.21  ? 547  LEU A O   1 
ATOM   1897 C  CB  . LEU A 1 284 ? -11.655 -17.854 -21.577 0.50 36.74  ? 547  LEU A CB  1 
ATOM   1898 C  CG  . LEU A 1 284 ? -11.376 -18.867 -20.471 0.50 36.63  ? 547  LEU A CG  1 
ATOM   1899 C  CD1 . LEU A 1 284 ? -11.477 -18.209 -19.106 0.50 38.84  ? 547  LEU A CD1 1 
ATOM   1900 C  CD2 . LEU A 1 284 ? -12.324 -20.054 -20.558 0.50 37.37  ? 547  LEU A CD2 1 
ATOM   1901 N  N   . LYS A 1 285 ? -11.159 -16.302 -24.257 0.50 34.64  ? 548  LYS A N   1 
ATOM   1902 C  CA  . LYS A 1 285 ? -11.400 -15.274 -25.304 0.50 38.04  ? 548  LYS A CA  1 
ATOM   1903 C  C   . LYS A 1 285 ? -11.572 -15.987 -26.647 0.50 38.68  ? 548  LYS A C   1 
ATOM   1904 O  O   . LYS A 1 285 ? -12.427 -15.548 -27.439 0.50 38.37  ? 548  LYS A O   1 
ATOM   1905 C  CB  . LYS A 1 285 ? -10.263 -14.244 -25.367 0.50 38.52  ? 548  LYS A CB  1 
ATOM   1906 C  CG  . LYS A 1 285 ? -10.155 -13.312 -24.168 0.50 38.73  ? 548  LYS A CG  1 
ATOM   1907 C  CD  . LYS A 1 285 ? -8.980  -12.347 -24.234 0.50 41.68  ? 548  LYS A CD  1 
ATOM   1908 C  CE  . LYS A 1 285 ? -8.989  -11.304 -23.131 0.50 43.80  ? 548  LYS A CE  1 
ATOM   1909 N  NZ  . LYS A 1 285 ? -7.680  -10.613 -23.004 0.50 45.70  ? 548  LYS A NZ  1 
ATOM   1910 N  N   . ASN A 1 286 ? -10.792 -17.044 -26.903 1.00 36.78  ? 549  ASN A N   1 
ATOM   1911 C  CA  . ASN A 1 286 ? -10.909 -17.763 -28.190 1.00 35.76  ? 549  ASN A CA  1 
ATOM   1912 C  C   . ASN A 1 286 ? -12.212 -18.598 -28.239 1.00 31.91  ? 549  ASN A C   1 
ATOM   1913 O  O   . ASN A 1 286 ? -12.877 -18.641 -29.291 1.00 34.91  ? 549  ASN A O   1 
ATOM   1914 C  CB  . ASN A 1 286 ? -9.618  -18.525 -28.479 1.00 39.88  ? 549  ASN A CB  1 
ATOM   1915 C  CG  . ASN A 1 286 ? -8.467  -17.565 -28.726 1.00 46.63  ? 549  ASN A CG  1 
ATOM   1916 O  OD1 . ASN A 1 286 ? -8.658  -16.520 -29.341 1.00 43.47  ? 549  ASN A OD1 1 
ATOM   1917 N  ND2 . ASN A 1 286 ? -7.267  -17.922 -28.300 1.00 43.32  ? 549  ASN A ND2 1 
ATOM   1918 N  N   . GLU A 1 287 ? -12.564 -19.262 -27.143 0.50 32.79  ? 550  GLU A N   1 
ATOM   1919 C  CA  . GLU A 1 287 ? -13.809 -20.070 -27.064 0.50 32.74  ? 550  GLU A CA  1 
ATOM   1920 C  C   . GLU A 1 287 ? -14.994 -19.118 -27.307 0.50 33.66  ? 550  GLU A C   1 
ATOM   1921 O  O   . GLU A 1 287 ? -15.803 -19.391 -28.226 0.50 27.29  ? 550  GLU A O   1 
ATOM   1922 C  CB  . GLU A 1 287 ? -13.853 -20.798 -25.721 0.50 31.51  ? 550  GLU A CB  1 
ATOM   1923 C  CG  . GLU A 1 287 ? -12.735 -21.821 -25.580 0.50 33.57  ? 550  GLU A CG  1 
ATOM   1924 C  CD  . GLU A 1 287 ? -12.575 -22.442 -24.203 0.50 33.93  ? 550  GLU A CD  1 
ATOM   1925 O  OE1 . GLU A 1 287 ? -13.378 -22.119 -23.310 0.50 37.99  ? 550  GLU A OE1 1 
ATOM   1926 O  OE2 . GLU A 1 287 ? -11.640 -23.258 -24.025 0.50 39.96  ? 550  GLU A OE2 1 
ATOM   1927 N  N   . GLU A 1 288 ? -14.998 -17.990 -26.589 0.50 35.28  ? 551  GLU A N   1 
ATOM   1928 C  CA  . GLU A 1 288 ? -16.060 -16.946 -26.614 0.50 37.27  ? 551  GLU A CA  1 
ATOM   1929 C  C   . GLU A 1 288 ? -16.380 -16.529 -28.051 0.50 39.02  ? 551  GLU A C   1 
ATOM   1930 O  O   . GLU A 1 288 ? -17.525 -16.087 -28.276 0.50 41.47  ? 551  GLU A O   1 
ATOM   1931 C  CB  . GLU A 1 288 ? -15.629 -15.730 -25.791 0.50 40.99  ? 551  GLU A CB  1 
ATOM   1932 C  CG  . GLU A 1 288 ? -16.753 -14.731 -25.520 0.50 42.69  ? 551  GLU A CG  1 
ATOM   1933 C  CD  . GLU A 1 288 ? -16.792 -13.507 -26.424 0.50 44.89  ? 551  GLU A CD  1 
ATOM   1934 O  OE1 . GLU A 1 288 ? -15.899 -13.382 -27.288 0.50 46.63  ? 551  GLU A OE1 1 
ATOM   1935 O  OE2 . GLU A 1 288 ? -17.716 -12.672 -26.257 0.50 44.41  ? 551  GLU A OE2 1 
ATOM   1936 N  N   . MET A 1 289 ? -15.429 -16.657 -28.984 1.00 35.78  ? 552  MET A N   1 
ATOM   1937 C  CA  . MET A 1 289 ? -15.652 -16.270 -30.399 1.00 37.11  ? 552  MET A CA  1 
ATOM   1938 C  C   . MET A 1 289 ? -16.772 -17.092 -31.055 1.00 38.84  ? 552  MET A C   1 
ATOM   1939 O  O   . MET A 1 289 ? -17.204 -16.717 -32.175 1.00 36.62  ? 552  MET A O   1 
ATOM   1940 C  CB  . MET A 1 289 ? -14.362 -16.362 -31.234 1.00 38.72  ? 552  MET A CB  1 
ATOM   1941 C  CG  . MET A 1 289 ? -13.273 -15.379 -30.769 1.00 44.40  ? 552  MET A CG  1 
ATOM   1942 S  SD  . MET A 1 289 ? -12.043 -14.919 -32.082 1.00 53.80  ? 552  MET A SD  1 
ATOM   1943 C  CE  . MET A 1 289 ? -11.318 -16.505 -32.467 1.00 49.26  ? 552  MET A CE  1 
ATOM   1944 N  N   . VAL A 1 290 ? -17.251 -18.187 -30.450 1.00 35.60  ? 553  VAL A N   1 
ATOM   1945 C  CA  . VAL A 1 290 ? -18.456 -18.878 -30.993 1.00 33.41  ? 553  VAL A CA  1 
ATOM   1946 C  C   . VAL A 1 290 ? -19.605 -17.858 -31.091 1.00 31.93  ? 553  VAL A C   1 
ATOM   1947 O  O   . VAL A 1 290 ? -20.419 -17.983 -32.049 1.00 37.01  ? 553  VAL A O   1 
ATOM   1948 C  CB  . VAL A 1 290 ? -18.824 -20.139 -30.180 1.00 31.72  ? 553  VAL A CB  1 
ATOM   1949 C  CG1 . VAL A 1 290 ? -19.259 -19.859 -28.756 1.00 32.07  ? 553  VAL A CG1 1 
ATOM   1950 C  CG2 . VAL A 1 290 ? -19.875 -20.912 -30.904 1.00 31.10  ? 553  VAL A CG2 1 
ATOM   1951 N  N   . THR A 1 291 ? -19.648 -16.858 -30.206 1.00 33.68  ? 554  THR A N   1 
ATOM   1952 C  CA  . THR A 1 291 ? -20.747 -15.824 -30.173 1.00 37.08  ? 554  THR A CA  1 
ATOM   1953 C  C   . THR A 1 291 ? -20.762 -14.923 -31.408 1.00 39.06  ? 554  THR A C   1 
ATOM   1954 O  O   . THR A 1 291 ? -21.840 -14.333 -31.692 1.00 42.18  ? 554  THR A O   1 
ATOM   1955 C  CB  . THR A 1 291 ? -20.645 -14.873 -28.990 1.00 36.39  ? 554  THR A CB  1 
ATOM   1956 O  OG1 . THR A 1 291 ? -19.404 -14.186 -29.167 1.00 36.74  ? 554  THR A OG1 1 
ATOM   1957 C  CG2 . THR A 1 291 ? -20.745 -15.589 -27.667 1.00 39.25  ? 554  THR A CG2 1 
ATOM   1958 N  N   . ASN A 1 292 ? -19.637 -14.783 -32.108 1.00 40.48  ? 555  ASN A N   1 
ATOM   1959 C  CA  . ASN A 1 292 ? -19.546 -14.074 -33.413 1.00 43.54  ? 555  ASN A CA  1 
ATOM   1960 C  C   . ASN A 1 292 ? -20.490 -14.689 -34.446 1.00 50.27  ? 555  ASN A C   1 
ATOM   1961 O  O   . ASN A 1 292 ? -20.696 -14.051 -35.504 1.00 49.60  ? 555  ASN A O   1 
ATOM   1962 C  CB  . ASN A 1 292 ? -18.152 -14.123 -34.037 1.00 40.10  ? 555  ASN A CB  1 
ATOM   1963 C  CG  . ASN A 1 292 ? -17.128 -13.445 -33.161 1.00 42.89  ? 555  ASN A CG  1 
ATOM   1964 O  OD1 . ASN A 1 292 ? -17.485 -12.779 -32.190 1.00 47.10  ? 555  ASN A OD1 1 
ATOM   1965 N  ND2 . ASN A 1 292 ? -15.862 -13.694 -33.441 1.00 48.84  ? 555  ASN A ND2 1 
ATOM   1966 N  N   . HIS A 1 293 ? -20.963 -15.913 -34.196 1.00 45.78  ? 556  HIS A N   1 
ATOM   1967 C  CA  . HIS A 1 293 ? -21.778 -16.723 -35.139 1.00 49.21  ? 556  HIS A CA  1 
ATOM   1968 C  C   . HIS A 1 293 ? -23.262 -16.668 -34.743 1.00 42.20  ? 556  HIS A C   1 
ATOM   1969 O  O   . HIS A 1 293 ? -24.080 -17.391 -35.334 1.00 42.23  ? 556  HIS A O   1 
ATOM   1970 C  CB  . HIS A 1 293 ? -21.197 -18.150 -35.188 1.00 49.87  ? 556  HIS A CB  1 
ATOM   1971 C  CG  . HIS A 1 293 ? -19.809 -18.163 -35.732 1.00 53.90  ? 556  HIS A CG  1 
ATOM   1972 N  ND1 . HIS A 1 293 ? -19.546 -18.348 -37.095 1.00 51.79  ? 556  HIS A ND1 1 
ATOM   1973 C  CD2 . HIS A 1 293 ? -18.614 -17.956 -35.125 1.00 50.82  ? 556  HIS A CD2 1 
ATOM   1974 C  CE1 . HIS A 1 293 ? -18.243 -18.285 -37.281 1.00 48.21  ? 556  HIS A CE1 1 
ATOM   1975 N  NE2 . HIS A 1 293 ? -17.661 -18.006 -36.098 1.00 46.57  ? 556  HIS A NE2 1 
ATOM   1976 N  N   . MET A 1 294 ? -23.567 -15.941 -33.687 1.00 37.64  ? 557  MET A N   1 
ATOM   1977 C  CA  . MET A 1 294 ? -24.918 -15.870 -33.100 1.00 38.29  ? 557  MET A CA  1 
ATOM   1978 C  C   . MET A 1 294 ? -25.552 -14.521 -33.466 1.00 46.47  ? 557  MET A C   1 
ATOM   1979 O  O   . MET A 1 294 ? -24.911 -13.758 -34.167 1.00 43.84  ? 557  MET A O   1 
ATOM   1980 C  CB  . MET A 1 294 ? -24.815 -16.008 -31.595 1.00 39.48  ? 557  MET A CB  1 
ATOM   1981 C  CG  . MET A 1 294 ? -24.232 -17.348 -31.181 1.00 37.85  ? 557  MET A CG  1 
ATOM   1982 S  SD  . MET A 1 294 ? -24.110 -17.341 -29.412 1.00 36.25  ? 557  MET A SD  1 
ATOM   1983 C  CE  . MET A 1 294 ? -23.449 -18.990 -29.096 1.00 44.04  ? 557  MET A CE  1 
ATOM   1984 N  N   . GLU A 1 295 ? -26.797 -14.298 -33.053 1.00 50.15  ? 558  GLU A N   1 
ATOM   1985 C  CA  . GLU A 1 295 ? -27.557 -13.048 -33.312 1.00 49.08  ? 558  GLU A CA  1 
ATOM   1986 C  C   . GLU A 1 295 ? -28.624 -12.899 -32.237 1.00 49.76  ? 558  GLU A C   1 
ATOM   1987 O  O   . GLU A 1 295 ? -28.892 -13.883 -31.511 1.00 46.37  ? 558  GLU A O   1 
ATOM   1988 C  CB  . GLU A 1 295 ? -28.155 -13.120 -34.713 1.00 52.05  ? 558  GLU A CB  1 
ATOM   1989 C  CG  . GLU A 1 295 ? -29.299 -14.099 -34.839 1.00 50.77  ? 558  GLU A CG  1 
ATOM   1990 C  CD  . GLU A 1 295 ? -29.745 -14.416 -36.259 1.00 65.41  ? 558  GLU A CD  1 
ATOM   1991 O  OE1 . GLU A 1 295 ? -28.899 -14.404 -37.211 1.00 64.49  ? 558  GLU A OE1 1 
ATOM   1992 O  OE2 . GLU A 1 295 ? -30.950 -14.692 -36.407 1.00 62.17  ? 558  GLU A OE2 1 
ATOM   1993 N  N   . GLY A 1 296 ? -29.217 -11.706 -32.162 1.00 57.07  ? 559  GLY A N   1 
ATOM   1994 C  CA  . GLY A 1 296 ? -30.347 -11.371 -31.274 1.00 52.75  ? 559  GLY A CA  1 
ATOM   1995 C  C   . GLY A 1 296 ? -30.026 -11.634 -29.817 1.00 51.01  ? 559  GLY A C   1 
ATOM   1996 O  O   . GLY A 1 296 ? -28.844 -11.445 -29.415 1.00 56.22  ? 559  GLY A O   1 
ATOM   1997 N  N   . GLU A 1 297 ? -31.051 -12.093 -29.095 1.00 45.06  ? 560  GLU A N   1 
ATOM   1998 C  CA  . GLU A 1 297 ? -31.077 -12.503 -27.668 1.00 48.77  ? 560  GLU A CA  1 
ATOM   1999 C  C   . GLU A 1 297 ? -30.046 -13.624 -27.373 1.00 47.69  ? 560  GLU A C   1 
ATOM   2000 O  O   . GLU A 1 297 ? -29.410 -13.606 -26.312 1.00 45.35  ? 560  GLU A O   1 
ATOM   2001 C  CB  . GLU A 1 297 ? -32.485 -13.008 -27.387 1.00 50.25  ? 560  GLU A CB  1 
ATOM   2002 C  CG  . GLU A 1 297 ? -32.801 -13.182 -25.939 1.00 54.30  ? 560  GLU A CG  1 
ATOM   2003 C  CD  . GLU A 1 297 ? -34.284 -13.299 -25.651 1.00 68.57  ? 560  GLU A CD  1 
ATOM   2004 O  OE1 . GLU A 1 297 ? -34.794 -14.445 -25.721 1.00 65.32  ? 560  GLU A OE1 1 
ATOM   2005 O  OE2 . GLU A 1 297 ? -34.923 -12.251 -25.348 1.00 74.88  ? 560  GLU A OE2 1 
ATOM   2006 N  N   . HIS A 1 298 ? -29.911 -14.593 -28.264 1.00 47.51  ? 561  HIS A N   1 
ATOM   2007 C  CA  . HIS A 1 298 ? -28.949 -15.720 -28.108 1.00 42.60  ? 561  HIS A CA  1 
ATOM   2008 C  C   . HIS A 1 298 ? -27.532 -15.159 -27.943 1.00 41.65  ? 561  HIS A C   1 
ATOM   2009 O  O   . HIS A 1 298 ? -26.886 -15.470 -26.931 1.00 48.09  ? 561  HIS A O   1 
ATOM   2010 C  CB  . HIS A 1 298 ? -29.018 -16.675 -29.288 1.00 40.61  ? 561  HIS A CB  1 
ATOM   2011 C  CG  . HIS A 1 298 ? -28.156 -17.863 -29.041 1.00 43.01  ? 561  HIS A CG  1 
ATOM   2012 N  ND1 . HIS A 1 298 ? -27.687 -18.653 -30.063 1.00 40.04  ? 561  HIS A ND1 1 
ATOM   2013 C  CD2 . HIS A 1 298 ? -27.643 -18.355 -27.886 1.00 38.24  ? 561  HIS A CD2 1 
ATOM   2014 C  CE1 . HIS A 1 298 ? -26.938 -19.605 -29.555 1.00 38.30  ? 561  HIS A CE1 1 
ATOM   2015 N  NE2 . HIS A 1 298 ? -26.926 -19.474 -28.215 1.00 40.82  ? 561  HIS A NE2 1 
ATOM   2016 N  N   . LYS A 1 299 ? -27.100 -14.303 -28.863 1.00 43.26  ? 562  LYS A N   1 
ATOM   2017 C  CA  . LYS A 1 299 ? -25.771 -13.657 -28.827 1.00 45.02  ? 562  LYS A CA  1 
ATOM   2018 C  C   . LYS A 1 299 ? -25.552 -13.007 -27.455 1.00 52.91  ? 562  LYS A C   1 
ATOM   2019 O  O   . LYS A 1 299 ? -24.467 -13.232 -26.865 1.00 47.52  ? 562  LYS A O   1 
ATOM   2020 C  CB  . LYS A 1 299 ? -25.594 -12.702 -30.004 1.00 44.27  ? 562  LYS A CB  1 
ATOM   2021 C  CG  . LYS A 1 299 ? -24.290 -11.911 -29.995 1.00 45.31  ? 562  LYS A CG  1 
ATOM   2022 C  CD  . LYS A 1 299 ? -23.915 -11.456 -31.374 1.00 49.49  ? 562  LYS A CD  1 
ATOM   2023 C  CE  . LYS A 1 299 ? -22.846 -10.387 -31.436 1.00 49.34  ? 562  LYS A CE  1 
ATOM   2024 N  NZ  . LYS A 1 299 ? -21.610 -10.931 -32.028 1.00 54.63  ? 562  LYS A NZ  1 
ATOM   2025 N  N   . LYS A 1 300 ? -26.528 -12.273 -26.921 1.00 52.87  ? 563  LYS A N   1 
ATOM   2026 C  CA  . LYS A 1 300 ? -26.301 -11.480 -25.675 1.00 57.49  ? 563  LYS A CA  1 
ATOM   2027 C  C   . LYS A 1 300 ? -26.264 -12.441 -24.500 1.00 44.00  ? 563  LYS A C   1 
ATOM   2028 O  O   . LYS A 1 300 ? -25.439 -12.288 -23.627 1.00 46.77  ? 563  LYS A O   1 
ATOM   2029 C  CB  . LYS A 1 300 ? -27.408 -10.449 -25.399 1.00 69.00  ? 563  LYS A CB  1 
ATOM   2030 C  CG  . LYS A 1 300 ? -27.457 -9.279  -26.373 1.00 78.47  ? 563  LYS A CG  1 
ATOM   2031 C  CD  . LYS A 1 300 ? -26.199 -8.429  -26.432 1.00 76.57  ? 563  LYS A CD  1 
ATOM   2032 C  CE  . LYS A 1 300 ? -25.978 -7.821  -27.801 1.00 83.14  ? 563  LYS A CE  1 
ATOM   2033 N  NZ  . LYS A 1 300 ? -25.207 -6.558  -27.723 1.00 89.61  ? 563  LYS A NZ  1 
ATOM   2034 N  N   . LEU A 1 301 ? -27.167 -13.404 -24.502 1.00 46.64  ? 564  LEU A N   1 
ATOM   2035 C  CA  . LEU A 1 301 ? -27.222 -14.432 -23.445 1.00 45.71  ? 564  LEU A CA  1 
ATOM   2036 C  C   . LEU A 1 301 ? -25.920 -15.286 -23.435 1.00 52.03  ? 564  LEU A C   1 
ATOM   2037 O  O   . LEU A 1 301 ? -25.441 -15.609 -22.320 1.00 44.16  ? 564  LEU A O   1 
ATOM   2038 C  CB  . LEU A 1 301 ? -28.474 -15.270 -23.692 1.00 51.70  ? 564  LEU A CB  1 
ATOM   2039 C  CG  . LEU A 1 301 ? -29.818 -14.593 -23.387 1.00 50.74  ? 564  LEU A CG  1 
ATOM   2040 C  CD1 . LEU A 1 301 ? -30.933 -15.515 -23.820 1.00 54.32  ? 564  LEU A CD1 1 
ATOM   2041 C  CD2 . LEU A 1 301 ? -29.958 -14.269 -21.904 1.00 50.13  ? 564  LEU A CD2 1 
ATOM   2042 N  N   . ALA A 1 302 ? -25.364 -15.671 -24.597 1.00 45.04  ? 565  ALA A N   1 
ATOM   2043 C  CA  . ALA A 1 302 ? -24.103 -16.464 -24.664 1.00 45.50  ? 565  ALA A CA  1 
ATOM   2044 C  C   . ALA A 1 302 ? -22.945 -15.576 -24.184 1.00 45.46  ? 565  ALA A C   1 
ATOM   2045 O  O   . ALA A 1 302 ? -22.108 -16.063 -23.423 1.00 42.85  ? 565  ALA A O   1 
ATOM   2046 C  CB  . ALA A 1 302 ? -23.867 -16.981 -26.060 1.00 43.98  ? 565  ALA A CB  1 
ATOM   2047 N  N   . GLU A 1 303 ? -22.929 -14.306 -24.598 1.00 44.58  ? 566  GLU A N   1 
ATOM   2048 C  CA  . GLU A 1 303 ? -21.858 -13.325 -24.252 1.00 47.40  ? 566  GLU A CA  1 
ATOM   2049 C  C   . GLU A 1 303 ? -21.810 -13.139 -22.732 1.00 44.80  ? 566  GLU A C   1 
ATOM   2050 O  O   . GLU A 1 303 ? -20.703 -13.059 -22.199 1.00 49.58  ? 566  GLU A O   1 
ATOM   2051 C  CB  . GLU A 1 303 ? -22.041 -11.999 -24.997 1.00 50.47  ? 566  GLU A CB  1 
ATOM   2052 C  CG  . GLU A 1 303 ? -21.648 -12.086 -26.448 1.00 53.52  ? 566  GLU A CG  1 
ATOM   2053 C  CD  . GLU A 1 303 ? -21.933 -10.805 -27.217 1.00 56.47  ? 566  GLU A CD  1 
ATOM   2054 O  OE1 . GLU A 1 303 ? -22.379 -9.894  -26.559 1.00 56.43  ? 566  GLU A OE1 1 
ATOM   2055 O  OE2 . GLU A 1 303 ? -21.703 -10.734 -28.479 1.00 53.88  ? 566  GLU A OE2 1 
ATOM   2056 N  N   . ALA A 1 304 ? -22.951 -13.187 -22.052 1.00 43.66  ? 567  ALA A N   1 
ATOM   2057 C  CA  . ALA A 1 304 ? -23.048 -13.058 -20.581 1.00 46.19  ? 567  ALA A CA  1 
ATOM   2058 C  C   . ALA A 1 304 ? -22.532 -14.319 -19.879 1.00 43.67  ? 567  ALA A C   1 
ATOM   2059 O  O   . ALA A 1 304 ? -21.931 -14.169 -18.788 1.00 42.36  ? 567  ALA A O   1 
ATOM   2060 C  CB  . ALA A 1 304 ? -24.471 -12.741 -20.156 1.00 47.61  ? 567  ALA A CB  1 
ATOM   2061 N  N   . ILE A 1 305 ? -22.848 -15.517 -20.385 1.00 43.01  ? 568  ILE A N   1 
ATOM   2062 C  CA  . ILE A 1 305 ? -22.283 -16.766 -19.791 1.00 44.41  ? 568  ILE A CA  1 
ATOM   2063 C  C   . ILE A 1 305 ? -20.746 -16.654 -19.812 1.00 38.83  ? 568  ILE A C   1 
ATOM   2064 O  O   . ILE A 1 305 ? -20.125 -16.788 -18.749 1.00 42.00  ? 568  ILE A O   1 
ATOM   2065 C  CB  . ILE A 1 305 ? -22.797 -18.041 -20.487 1.00 46.29  ? 568  ILE A CB  1 
ATOM   2066 C  CG1 . ILE A 1 305 ? -24.309 -18.238 -20.328 1.00 44.50  ? 568  ILE A CG1 1 
ATOM   2067 C  CG2 . ILE A 1 305 ? -21.998 -19.260 -20.008 1.00 45.79  ? 568  ILE A CG2 1 
ATOM   2068 C  CD1 . ILE A 1 305 ? -24.768 -18.349 -18.899 1.00 42.67  ? 568  ILE A CD1 1 
ATOM   2069 N  N   . PHE A 1 306 ? -20.150 -16.361 -20.961 1.00 39.86  ? 569  PHE A N   1 
ATOM   2070 C  CA  . PHE A 1 306 ? -18.677 -16.244 -21.146 1.00 43.39  ? 569  PHE A CA  1 
ATOM   2071 C  C   . PHE A 1 306 ? -18.075 -15.137 -20.246 1.00 50.42  ? 569  PHE A C   1 
ATOM   2072 O  O   . PHE A 1 306 ? -17.086 -15.404 -19.551 1.00 48.93  ? 569  PHE A O   1 
ATOM   2073 C  CB  . PHE A 1 306 ? -18.322 -16.037 -22.626 1.00 41.89  ? 569  PHE A CB  1 
ATOM   2074 C  CG  . PHE A 1 306 ? -18.286 -17.315 -23.424 1.00 47.52  ? 569  PHE A CG  1 
ATOM   2075 C  CD1 . PHE A 1 306 ? -17.263 -18.223 -23.250 1.00 48.45  ? 569  PHE A CD1 1 
ATOM   2076 C  CD2 . PHE A 1 306 ? -19.245 -17.593 -24.381 1.00 46.52  ? 569  PHE A CD2 1 
ATOM   2077 C  CE1 . PHE A 1 306 ? -17.250 -19.415 -23.954 1.00 42.52  ? 569  PHE A CE1 1 
ATOM   2078 C  CE2 . PHE A 1 306 ? -19.211 -18.765 -25.116 1.00 46.40  ? 569  PHE A CE2 1 
ATOM   2079 C  CZ  . PHE A 1 306 ? -18.234 -19.692 -24.866 1.00 44.88  ? 569  PHE A CZ  1 
ATOM   2080 N  N   . LYS A 1 307 ? -18.659 -13.930 -20.270 0.50 51.49  ? 570  LYS A N   1 
ATOM   2081 C  CA  . LYS A 1 307 ? -18.151 -12.732 -19.539 0.50 54.54  ? 570  LYS A CA  1 
ATOM   2082 C  C   . LYS A 1 307 ? -18.325 -12.905 -18.027 0.50 49.53  ? 570  LYS A C   1 
ATOM   2083 O  O   . LYS A 1 307 ? -17.338 -12.693 -17.297 0.50 50.02  ? 570  LYS A O   1 
ATOM   2084 C  CB  . LYS A 1 307 ? -18.887 -11.452 -19.949 0.50 62.52  ? 570  LYS A CB  1 
ATOM   2085 C  CG  . LYS A 1 307 ? -18.046 -10.423 -20.691 0.50 69.74  ? 570  LYS A CG  1 
ATOM   2086 C  CD  . LYS A 1 307 ? -18.654 -9.034  -20.679 0.50 77.58  ? 570  LYS A CD  1 
ATOM   2087 C  CE  . LYS A 1 307 ? -17.909 -8.053  -21.560 0.50 82.39  ? 570  LYS A CE  1 
ATOM   2088 N  NZ  . LYS A 1 307 ? -17.574 -8.649  -22.877 0.50 86.80  ? 570  LYS A NZ  1 
ATOM   2089 N  N   . LEU A 1 308 ? -19.534 -13.254 -17.580 1.00 45.41  ? 571  LEU A N   1 
ATOM   2090 C  CA  . LEU A 1 308 ? -19.918 -13.151 -16.149 1.00 48.38  ? 571  LEU A CA  1 
ATOM   2091 C  C   . LEU A 1 308 ? -19.635 -14.425 -15.378 1.00 50.78  ? 571  LEU A C   1 
ATOM   2092 O  O   . LEU A 1 308 ? -19.444 -14.312 -14.146 1.00 54.84  ? 571  LEU A O   1 
ATOM   2093 C  CB  . LEU A 1 308 ? -21.404 -12.771 -16.062 1.00 48.47  ? 571  LEU A CB  1 
ATOM   2094 C  CG  . LEU A 1 308 ? -21.756 -11.460 -16.772 1.00 55.20  ? 571  LEU A CG  1 
ATOM   2095 C  CD1 . LEU A 1 308 ? -23.262 -11.325 -16.958 1.00 56.80  ? 571  LEU A CD1 1 
ATOM   2096 C  CD2 . LEU A 1 308 ? -21.192 -10.262 -16.017 1.00 52.78  ? 571  LEU A CD2 1 
ATOM   2097 N  N   . THR A 1 309 ? -19.677 -15.592 -16.022 1.00 49.50  ? 572  THR A N   1 
ATOM   2098 C  CA  . THR A 1 309 ? -19.594 -16.884 -15.296 1.00 45.74  ? 572  THR A CA  1 
ATOM   2099 C  C   . THR A 1 309 ? -18.329 -17.704 -15.610 1.00 46.11  ? 572  THR A C   1 
ATOM   2100 O  O   . THR A 1 309 ? -17.955 -18.493 -14.780 1.00 49.46  ? 572  THR A O   1 
ATOM   2101 C  CB  . THR A 1 309 ? -20.841 -17.734 -15.535 1.00 52.27  ? 572  THR A CB  1 
ATOM   2102 O  OG1 . THR A 1 309 ? -20.887 -18.076 -16.922 1.00 47.45  ? 572  THR A OG1 1 
ATOM   2103 C  CG2 . THR A 1 309 ? -22.097 -17.006 -15.112 1.00 55.45  ? 572  THR A CG2 1 
ATOM   2104 N  N   . TYR A 1 310 ? -17.703 -17.502 -16.773 0.50 44.76  ? 573  TYR A N   1 
ATOM   2105 C  CA  . TYR A 1 310 ? -16.570 -18.339 -17.262 0.50 45.18  ? 573  TYR A CA  1 
ATOM   2106 C  C   . TYR A 1 310 ? -15.253 -17.561 -17.122 0.50 43.51  ? 573  TYR A C   1 
ATOM   2107 O  O   . TYR A 1 310 ? -14.237 -18.196 -16.781 0.50 43.46  ? 573  TYR A O   1 
ATOM   2108 C  CB  . TYR A 1 310 ? -16.809 -18.805 -18.705 0.50 41.25  ? 573  TYR A CB  1 
ATOM   2109 C  CG  . TYR A 1 310 ? -17.807 -19.928 -18.900 0.50 38.17  ? 573  TYR A CG  1 
ATOM   2110 C  CD1 . TYR A 1 310 ? -18.625 -20.370 -17.875 0.50 37.89  ? 573  TYR A CD1 1 
ATOM   2111 C  CD2 . TYR A 1 310 ? -17.973 -20.517 -20.143 0.50 36.91  ? 573  TYR A CD2 1 
ATOM   2112 C  CE1 . TYR A 1 310 ? -19.554 -21.380 -18.066 0.50 37.11  ? 573  TYR A CE1 1 
ATOM   2113 C  CE2 . TYR A 1 310 ? -18.901 -21.521 -20.357 0.50 35.96  ? 573  TYR A CE2 1 
ATOM   2114 C  CZ  . TYR A 1 310 ? -19.692 -21.965 -19.312 0.50 37.85  ? 573  TYR A CZ  1 
ATOM   2115 O  OH  . TYR A 1 310 ? -20.613 -22.957 -19.513 0.50 39.06  ? 573  TYR A OH  1 
ATOM   2116 N  N   . GLN A 1 311 ? -15.276 -16.242 -17.358 0.50 42.97  ? 574  GLN A N   1 
ATOM   2117 C  CA  . GLN A 1 311 ? -14.069 -15.375 -17.449 0.50 44.29  ? 574  GLN A CA  1 
ATOM   2118 C  C   . GLN A 1 311 ? -13.900 -14.486 -16.207 0.50 46.25  ? 574  GLN A C   1 
ATOM   2119 O  O   . GLN A 1 311 ? -12.842 -13.832 -16.105 0.50 43.83  ? 574  GLN A O   1 
ATOM   2120 C  CB  . GLN A 1 311 ? -14.161 -14.462 -18.666 0.50 43.84  ? 574  GLN A CB  1 
ATOM   2121 C  CG  . GLN A 1 311 ? -13.965 -15.172 -19.992 0.50 42.98  ? 574  GLN A CG  1 
ATOM   2122 C  CD  . GLN A 1 311 ? -14.236 -14.218 -21.127 0.50 43.26  ? 574  GLN A CD  1 
ATOM   2123 O  OE1 . GLN A 1 311 ? -14.754 -13.123 -20.918 0.50 46.40  ? 574  GLN A OE1 1 
ATOM   2124 N  NE2 . GLN A 1 311 ? -13.882 -14.618 -22.337 0.50 44.09  ? 574  GLN A NE2 1 
ATOM   2125 N  N   . ASN A 1 312 ? -14.906 -14.433 -15.330 0.50 47.55  ? 575  ASN A N   1 
ATOM   2126 C  CA  . ASN A 1 312 ? -14.892 -13.633 -14.072 0.50 48.41  ? 575  ASN A CA  1 
ATOM   2127 C  C   . ASN A 1 312 ? -15.682 -14.392 -13.003 0.50 48.72  ? 575  ASN A C   1 
ATOM   2128 O  O   . ASN A 1 312 ? -16.727 -13.882 -12.562 0.50 52.58  ? 575  ASN A O   1 
ATOM   2129 C  CB  . ASN A 1 312 ? -15.480 -12.232 -14.267 0.50 46.47  ? 575  ASN A CB  1 
ATOM   2130 C  CG  . ASN A 1 312 ? -14.591 -11.307 -15.072 0.50 46.80  ? 575  ASN A CG  1 
ATOM   2131 O  OD1 . ASN A 1 312 ? -13.647 -10.730 -14.537 0.50 46.11  ? 575  ASN A OD1 1 
ATOM   2132 N  ND2 . ASN A 1 312 ? -14.902 -11.134 -16.348 0.50 43.63  ? 575  ASN A ND2 1 
ATOM   2133 N  N   . LYS A 1 313 ? -15.206 -15.571 -12.610 0.50 49.46  ? 576  LYS A N   1 
ATOM   2134 C  CA  . LYS A 1 313 ? -15.973 -16.505 -11.751 0.50 50.61  ? 576  LYS A CA  1 
ATOM   2135 C  C   . LYS A 1 313 ? -15.986 -15.987 -10.313 0.50 54.07  ? 576  LYS A C   1 
ATOM   2136 O  O   . LYS A 1 313 ? -15.201 -15.064 -9.995  0.50 55.38  ? 576  LYS A O   1 
ATOM   2137 C  CB  . LYS A 1 313 ? -15.364 -17.909 -11.746 0.50 51.52  ? 576  LYS A CB  1 
ATOM   2138 C  CG  . LYS A 1 313 ? -14.706 -18.347 -13.046 0.50 52.81  ? 576  LYS A CG  1 
ATOM   2139 C  CD  . LYS A 1 313 ? -13.874 -19.603 -12.894 0.50 51.28  ? 576  LYS A CD  1 
ATOM   2140 C  CE  . LYS A 1 313 ? -12.850 -19.733 -13.997 0.50 52.45  ? 576  LYS A CE  1 
ATOM   2141 N  NZ  . LYS A 1 313 ? -12.257 -18.414 -14.315 0.50 52.40  ? 576  LYS A NZ  1 
ATOM   2142 N  N   . VAL A 1 314 ? -16.851 -16.599 -9.503  0.50 51.20  ? 577  VAL A N   1 
ATOM   2143 C  CA  . VAL A 1 314 ? -16.913 -16.510 -8.019  0.50 49.70  ? 577  VAL A CA  1 
ATOM   2144 C  C   . VAL A 1 314 ? -17.330 -17.905 -7.546  0.50 50.22  ? 577  VAL A C   1 
ATOM   2145 O  O   . VAL A 1 314 ? -18.205 -18.489 -8.204  0.50 44.24  ? 577  VAL A O   1 
ATOM   2146 C  CB  . VAL A 1 314 ? -17.913 -15.426 -7.568  0.50 52.88  ? 577  VAL A CB  1 
ATOM   2147 C  CG1 . VAL A 1 314 ? -18.019 -15.352 -6.052  0.50 53.10  ? 577  VAL A CG1 1 
ATOM   2148 C  CG2 . VAL A 1 314 ? -17.583 -14.060 -8.156  0.50 51.92  ? 577  VAL A CG2 1 
ATOM   2149 N  N   . VAL A 1 315 ? -16.718 -18.441 -6.488  0.50 50.40  ? 578  VAL A N   1 
ATOM   2150 C  CA  . VAL A 1 315 ? -17.001 -19.832 -6.019  0.50 52.50  ? 578  VAL A CA  1 
ATOM   2151 C  C   . VAL A 1 315 ? -17.038 -19.877 -4.491  0.50 50.65  ? 578  VAL A C   1 
ATOM   2152 O  O   . VAL A 1 315 ? -16.441 -18.989 -3.856  0.50 53.61  ? 578  VAL A O   1 
ATOM   2153 C  CB  . VAL A 1 315 ? -15.967 -20.833 -6.566  0.50 54.42  ? 578  VAL A CB  1 
ATOM   2154 C  CG1 . VAL A 1 315 ? -15.916 -22.091 -5.717  0.50 55.67  ? 578  VAL A CG1 1 
ATOM   2155 C  CG2 . VAL A 1 315 ? -16.223 -21.173 -8.029  0.50 56.22  ? 578  VAL A CG2 1 
ATOM   2156 N  N   . ARG A 1 316 ? -17.691 -20.907 -3.946  0.50 53.96  ? 579  ARG A N   1 
ATOM   2157 C  CA  . ARG A 1 316 ? -17.781 -21.204 -2.493  0.50 55.26  ? 579  ARG A CA  1 
ATOM   2158 C  C   . ARG A 1 316 ? -17.007 -22.496 -2.200  0.50 59.06  ? 579  ARG A C   1 
ATOM   2159 O  O   . ARG A 1 316 ? -17.091 -23.428 -3.026  0.50 57.52  ? 579  ARG A O   1 
ATOM   2160 C  CB  . ARG A 1 316 ? -19.243 -21.380 -2.073  0.50 55.74  ? 579  ARG A CB  1 
ATOM   2161 C  CG  . ARG A 1 316 ? -20.222 -20.442 -2.763  0.50 55.57  ? 579  ARG A CG  1 
ATOM   2162 C  CD  . ARG A 1 316 ? -21.629 -20.995 -2.630  0.50 58.04  ? 579  ARG A CD  1 
ATOM   2163 N  NE  . ARG A 1 316 ? -22.683 -19.997 -2.707  0.50 55.58  ? 579  ARG A NE  1 
ATOM   2164 C  CZ  . ARG A 1 316 ? -23.889 -20.155 -2.179  0.50 57.08  ? 579  ARG A CZ  1 
ATOM   2165 N  NH1 . ARG A 1 316 ? -24.794 -19.198 -2.291  0.50 56.86  ? 579  ARG A NH1 1 
ATOM   2166 N  NH2 . ARG A 1 316 ? -24.182 -21.270 -1.530  0.50 59.38  ? 579  ARG A NH2 1 
ATOM   2167 N  N   . VAL A 1 317 ? -16.304 -22.550 -1.061  0.50 61.08  ? 580  VAL A N   1 
ATOM   2168 C  CA  . VAL A 1 317 ? -15.381 -23.662 -0.681  0.50 60.05  ? 580  VAL A CA  1 
ATOM   2169 C  C   . VAL A 1 317 ? -15.450 -23.906 0.831   0.50 60.01  ? 580  VAL A C   1 
ATOM   2170 O  O   . VAL A 1 317 ? -15.404 -22.923 1.594   0.50 56.84  ? 580  VAL A O   1 
ATOM   2171 C  CB  . VAL A 1 317 ? -13.932 -23.347 -1.095  0.50 58.36  ? 580  VAL A CB  1 
ATOM   2172 C  CG1 . VAL A 1 317 ? -13.046 -24.578 -0.992  0.50 57.69  ? 580  VAL A CG1 1 
ATOM   2173 C  CG2 . VAL A 1 317 ? -13.857 -22.746 -2.487  0.50 59.97  ? 580  VAL A CG2 1 
ATOM   2174 N  N   . GLN A 1 318 ? -15.528 -25.180 1.229   0.50 61.33  ? 581  GLN A N   1 
ATOM   2175 C  CA  . GLN A 1 318 ? -15.363 -25.652 2.630   0.50 62.13  ? 581  GLN A CA  1 
ATOM   2176 C  C   . GLN A 1 318 ? -13.937 -26.186 2.812   0.50 62.32  ? 581  GLN A C   1 
ATOM   2177 O  O   . GLN A 1 318 ? -13.666 -27.282 2.273   0.50 61.14  ? 581  GLN A O   1 
ATOM   2178 C  CB  . GLN A 1 318 ? -16.381 -26.745 2.956   0.50 61.13  ? 581  GLN A CB  1 
ATOM   2179 C  CG  . GLN A 1 318 ? -17.826 -26.298 2.807   0.50 60.54  ? 581  GLN A CG  1 
ATOM   2180 C  CD  . GLN A 1 318 ? -18.729 -26.990 3.799   0.50 61.29  ? 581  GLN A CD  1 
ATOM   2181 O  OE1 . GLN A 1 318 ? -18.324 -27.915 4.500   0.50 56.76  ? 581  GLN A OE1 1 
ATOM   2182 N  NE2 . GLN A 1 318 ? -19.966 -26.527 3.878   0.50 63.18  ? 581  GLN A NE2 1 
ATOM   2183 N  N   . MET A 1 327 ? -16.573 -21.136 4.756   0.50 62.95  ? 590  MET A N   1 
ATOM   2184 C  CA  . MET A 1 327 ? -16.873 -20.911 3.315   0.50 60.74  ? 590  MET A CA  1 
ATOM   2185 C  C   . MET A 1 327 ? -16.168 -19.630 2.856   0.50 58.68  ? 590  MET A C   1 
ATOM   2186 O  O   . MET A 1 327 ? -16.648 -18.533 3.206   0.50 59.56  ? 590  MET A O   1 
ATOM   2187 C  CB  . MET A 1 327 ? -18.381 -20.774 3.073   0.50 60.37  ? 590  MET A CB  1 
ATOM   2188 C  CG  . MET A 1 327 ? -18.800 -21.094 1.650   0.50 59.47  ? 590  MET A CG  1 
ATOM   2189 S  SD  . MET A 1 327 ? -18.709 -22.863 1.267   0.50 62.00  ? 590  MET A SD  1 
ATOM   2190 C  CE  . MET A 1 327 ? -20.108 -23.488 2.200   0.50 62.52  ? 590  MET A CE  1 
ATOM   2191 N  N   . ASP A 1 328 ? -15.060 -19.773 2.123   0.50 54.97  ? 591  ASP A N   1 
ATOM   2192 C  CA  . ASP A 1 328 ? -14.280 -18.650 1.538   0.50 54.90  ? 591  ASP A CA  1 
ATOM   2193 C  C   . ASP A 1 328 ? -14.930 -18.234 0.211   0.50 52.94  ? 591  ASP A C   1 
ATOM   2194 O  O   . ASP A 1 328 ? -15.400 -19.123 -0.532  0.50 50.36  ? 591  ASP A O   1 
ATOM   2195 C  CB  . ASP A 1 328 ? -12.812 -19.032 1.329   0.50 53.68  ? 591  ASP A CB  1 
ATOM   2196 C  CG  . ASP A 1 328 ? -12.096 -19.541 2.573   0.50 51.63  ? 591  ASP A CG  1 
ATOM   2197 O  OD1 . ASP A 1 328 ? -12.330 -18.977 3.661   0.50 48.02  ? 591  ASP A OD1 1 
ATOM   2198 O  OD2 . ASP A 1 328 ? -11.295 -20.498 2.437   0.50 50.60  ? 591  ASP A OD2 1 
ATOM   2199 N  N   . ILE A 1 329 ? -14.955 -16.929 -0.063  0.50 51.25  ? 592  ILE A N   1 
ATOM   2200 C  CA  . ILE A 1 329 ? -15.579 -16.314 -1.271  0.50 51.40  ? 592  ILE A CA  1 
ATOM   2201 C  C   . ILE A 1 329 ? -14.477 -15.710 -2.143  0.50 52.18  ? 592  ILE A C   1 
ATOM   2202 O  O   . ILE A 1 329 ? -14.130 -14.531 -1.925  0.50 50.23  ? 592  ILE A O   1 
ATOM   2203 C  CB  . ILE A 1 329 ? -16.619 -15.255 -0.863  0.50 53.17  ? 592  ILE A CB  1 
ATOM   2204 C  CG1 . ILE A 1 329 ? -17.801 -15.889 -0.129  0.50 53.96  ? 592  ILE A CG1 1 
ATOM   2205 C  CG2 . ILE A 1 329 ? -17.067 -14.451 -2.070  0.50 55.61  ? 592  ILE A CG2 1 
ATOM   2206 C  CD1 . ILE A 1 329 ? -18.401 -17.078 -0.844  0.50 54.49  ? 592  ILE A CD1 1 
ATOM   2207 N  N   . ILE A 1 330 ? -13.978 -16.491 -3.108  0.50 52.64  ? 593  ILE A N   1 
ATOM   2208 C  CA  . ILE A 1 330 ? -12.788 -16.173 -3.954  0.50 50.77  ? 593  ILE A CA  1 
ATOM   2209 C  C   . ILE A 1 330 ? -13.241 -15.958 -5.403  0.50 48.75  ? 593  ILE A C   1 
ATOM   2210 O  O   . ILE A 1 330 ? -14.333 -16.430 -5.759  0.50 44.76  ? 593  ILE A O   1 
ATOM   2211 C  CB  . ILE A 1 330 ? -11.760 -17.316 -3.857  0.50 50.39  ? 593  ILE A CB  1 
ATOM   2212 C  CG1 . ILE A 1 330 ? -12.344 -18.620 -4.415  0.50 51.21  ? 593  ILE A CG1 1 
ATOM   2213 C  CG2 . ILE A 1 330 ? -11.259 -17.464 -2.426  0.50 49.62  ? 593  ILE A CG2 1 
ATOM   2214 C  CD1 . ILE A 1 330 ? -11.410 -19.807 -4.368  0.50 50.90  ? 593  ILE A CD1 1 
ATOM   2215 N  N   . SER A 1 331 ? -12.371 -15.406 -6.247  0.50 49.73  ? 594  SER A N   1 
ATOM   2216 C  CA  . SER A 1 331 ? -12.699 -15.234 -7.683  0.50 50.92  ? 594  SER A CA  1 
ATOM   2217 C  C   . SER A 1 331 ? -11.466 -15.514 -8.538  0.50 53.46  ? 594  SER A C   1 
ATOM   2218 O  O   . SER A 1 331 ? -10.359 -15.123 -8.115  0.50 50.12  ? 594  SER A O   1 
ATOM   2219 C  CB  . SER A 1 331 ? -13.188 -13.844 -7.932  0.50 49.77  ? 594  SER A CB  1 
ATOM   2220 O  OG  . SER A 1 331 ? -12.149 -12.905 -7.705  0.50 49.63  ? 594  SER A OG  1 
ATOM   2221 N  N   . ARG A 1 332 ? -11.640 -16.189 -9.670  0.50 55.79  ? 595  ARG A N   1 
ATOM   2222 C  CA  . ARG A 1 332 ? -10.493 -16.344 -10.600 0.50 58.44  ? 595  ARG A CA  1 
ATOM   2223 C  C   . ARG A 1 332 ? -11.017 -16.035 -11.994 0.50 58.58  ? 595  ARG A C   1 
ATOM   2224 O  O   . ARG A 1 332 ? -12.192 -16.323 -12.248 0.50 59.93  ? 595  ARG A O   1 
ATOM   2225 C  CB  . ARG A 1 332 ? -9.818  -17.717 -10.508 0.50 62.31  ? 595  ARG A CB  1 
ATOM   2226 C  CG  . ARG A 1 332 ? -10.346 -18.780 -11.456 0.50 66.64  ? 595  ARG A CG  1 
ATOM   2227 C  CD  . ARG A 1 332 ? -9.427  -19.983 -11.364 0.50 69.07  ? 595  ARG A CD  1 
ATOM   2228 N  NE  . ARG A 1 332 ? -8.057  -19.618 -11.693 0.50 68.69  ? 595  ARG A NE  1 
ATOM   2229 C  CZ  . ARG A 1 332 ? -7.044  -19.596 -10.835 0.50 69.02  ? 595  ARG A CZ  1 
ATOM   2230 N  NH1 . ARG A 1 332 ? -7.228  -19.943 -9.572  0.50 68.18  ? 595  ARG A NH1 1 
ATOM   2231 N  NH2 . ARG A 1 332 ? -5.843  -19.240 -11.252 0.50 68.97  ? 595  ARG A NH2 1 
ATOM   2232 N  N   . ARG A 1 333 ? -10.176 -15.431 -12.820 0.50 59.71  ? 596  ARG A N   1 
ATOM   2233 C  CA  . ARG A 1 333 ? -10.627 -15.026 -14.168 0.50 63.28  ? 596  ARG A CA  1 
ATOM   2234 C  C   . ARG A 1 333 ? -10.114 -16.032 -15.207 0.50 60.21  ? 596  ARG A C   1 
ATOM   2235 O  O   . ARG A 1 333 ? -10.223 -15.735 -16.412 0.50 55.92  ? 596  ARG A O   1 
ATOM   2236 C  CB  . ARG A 1 333 ? -10.127 -13.612 -14.477 0.50 69.72  ? 596  ARG A CB  1 
ATOM   2237 C  CG  . ARG A 1 333 ? -10.783 -12.511 -13.659 0.50 72.04  ? 596  ARG A CG  1 
ATOM   2238 C  CD  . ARG A 1 333 ? -10.706 -11.189 -14.400 0.50 77.14  ? 596  ARG A CD  1 
ATOM   2239 N  NE  . ARG A 1 333 ? -11.345 -11.270 -15.708 0.50 81.35  ? 596  ARG A NE  1 
ATOM   2240 C  CZ  . ARG A 1 333 ? -10.740 -11.035 -16.867 0.50 85.80  ? 596  ARG A CZ  1 
ATOM   2241 N  NH1 . ARG A 1 333 ? -9.467  -10.681 -16.890 0.50 86.94  ? 596  ARG A NH1 1 
ATOM   2242 N  NH2 . ARG A 1 333 ? -11.416 -11.137 -17.997 0.50 84.21  ? 596  ARG A NH2 1 
ATOM   2243 N  N   . ASP A 1 334 ? -9.561  -17.156 -14.746 0.50 55.33  ? 597  ASP A N   1 
ATOM   2244 C  CA  . ASP A 1 334 ? -9.019  -18.179 -15.675 0.50 53.59  ? 597  ASP A CA  1 
ATOM   2245 C  C   . ASP A 1 334 ? -9.334  -19.589 -15.166 0.50 49.03  ? 597  ASP A C   1 
ATOM   2246 O  O   . ASP A 1 334 ? -10.047 -19.696 -14.164 0.50 47.94  ? 597  ASP A O   1 
ATOM   2247 C  CB  . ASP A 1 334 ? -7.524  -17.977 -15.929 0.50 54.42  ? 597  ASP A CB  1 
ATOM   2248 C  CG  . ASP A 1 334 ? -6.648  -18.393 -14.762 0.50 55.71  ? 597  ASP A CG  1 
ATOM   2249 O  OD1 . ASP A 1 334 ? -7.161  -18.423 -13.633 0.50 57.18  ? 597  ASP A OD1 1 
ATOM   2250 O  OD2 . ASP A 1 334 ? -5.463  -18.691 -15.000 0.50 55.26  ? 597  ASP A OD2 1 
ATOM   2251 N  N   . GLN A 1 335 ? -8.816  -20.618 -15.836 0.50 45.88  ? 598  GLN A N   1 
ATOM   2252 C  CA  . GLN A 1 335 ? -9.092  -22.043 -15.504 0.50 44.01  ? 598  GLN A CA  1 
ATOM   2253 C  C   . GLN A 1 335 ? -10.497 -22.432 -15.982 0.50 43.92  ? 598  GLN A C   1 
ATOM   2254 O  O   . GLN A 1 335 ? -11.353 -21.539 -16.091 0.50 44.36  ? 598  GLN A O   1 
ATOM   2255 C  CB  . GLN A 1 335 ? -8.897  -22.340 -14.015 0.50 44.07  ? 598  GLN A CB  1 
ATOM   2256 C  CG  . GLN A 1 335 ? -7.456  -22.180 -13.554 0.50 44.44  ? 598  GLN A CG  1 
ATOM   2257 C  CD  . GLN A 1 335 ? -7.185  -22.827 -12.218 0.50 44.07  ? 598  GLN A CD  1 
ATOM   2258 O  OE1 . GLN A 1 335 ? -8.095  -23.275 -11.525 0.50 47.62  ? 598  GLN A OE1 1 
ATOM   2259 N  NE2 . GLN A 1 335 ? -5.917  -22.884 -11.848 0.50 42.90  ? 598  GLN A NE2 1 
ATOM   2260 N  N   . ARG A 1 336 ? -10.710 -23.718 -16.267 0.50 42.10  ? 599  ARG A N   1 
ATOM   2261 C  CA  . ARG A 1 336 ? -12.061 -24.209 -16.639 0.50 43.65  ? 599  ARG A CA  1 
ATOM   2262 C  C   . ARG A 1 336 ? -12.883 -24.446 -15.368 0.50 45.38  ? 599  ARG A C   1 
ATOM   2263 O  O   . ARG A 1 336 ? -12.399 -25.164 -14.483 0.50 45.16  ? 599  ARG A O   1 
ATOM   2264 C  CB  . ARG A 1 336 ? -11.951 -25.488 -17.477 0.50 42.36  ? 599  ARG A CB  1 
ATOM   2265 C  CG  . ARG A 1 336 ? -13.283 -26.156 -17.787 0.50 40.29  ? 599  ARG A CG  1 
ATOM   2266 C  CD  . ARG A 1 336 ? -13.954 -25.611 -19.032 0.50 38.30  ? 599  ARG A CD  1 
ATOM   2267 N  NE  . ARG A 1 336 ? -13.212 -25.909 -20.248 0.50 36.27  ? 599  ARG A NE  1 
ATOM   2268 C  CZ  . ARG A 1 336 ? -12.797 -24.999 -21.119 0.50 35.20  ? 599  ARG A CZ  1 
ATOM   2269 N  NH1 . ARG A 1 336 ? -13.066 -23.721 -20.919 0.50 35.77  ? 599  ARG A NH1 1 
ATOM   2270 N  NH2 . ARG A 1 336 ? -12.131 -25.372 -22.197 0.50 33.91  ? 599  ARG A NH2 1 
ATOM   2271 N  N   . GLY A 1 337 ? -14.068 -23.843 -15.285 0.50 48.68  ? 600  GLY A N   1 
ATOM   2272 C  CA  . GLY A 1 337 ? -14.981 -24.013 -14.139 0.50 52.94  ? 600  GLY A CA  1 
ATOM   2273 C  C   . GLY A 1 337 ? -16.428 -23.833 -14.554 0.50 54.00  ? 600  GLY A C   1 
ATOM   2274 O  O   . GLY A 1 337 ? -17.088 -22.933 -14.006 0.50 60.84  ? 600  GLY A O   1 
ATOM   2275 N  N   . SER A 1 338 ? -16.910 -24.665 -15.483 0.50 55.74  ? 601  SER A N   1 
ATOM   2276 C  CA  . SER A 1 338 ? -18.281 -24.589 -16.054 0.50 53.71  ? 601  SER A CA  1 
ATOM   2277 C  C   . SER A 1 338 ? -18.992 -25.942 -15.942 0.50 52.44  ? 601  SER A C   1 
ATOM   2278 O  O   . SER A 1 338 ? -18.537 -26.794 -15.153 0.50 56.27  ? 601  SER A O   1 
ATOM   2279 C  CB  . SER A 1 338 ? -18.235 -24.112 -17.480 0.50 54.31  ? 601  SER A CB  1 
ATOM   2280 O  OG  . SER A 1 338 ? -17.513 -25.023 -18.296 0.50 52.25  ? 601  SER A OG  1 
ATOM   2281 N  N   . GLY A 1 339 ? -20.081 -26.120 -16.694 0.50 53.24  ? 602  GLY A N   1 
ATOM   2282 C  CA  . GLY A 1 339 ? -20.853 -27.378 -16.720 0.50 54.61  ? 602  GLY A CA  1 
ATOM   2283 C  C   . GLY A 1 339 ? -20.069 -28.483 -17.405 0.50 53.06  ? 602  GLY A C   1 
ATOM   2284 O  O   . GLY A 1 339 ? -19.406 -28.179 -18.403 0.50 53.08  ? 602  GLY A O   1 
ATOM   2285 N  N   . GLN A 1 340 ? -20.152 -29.717 -16.897 0.50 52.38  ? 603  GLN A N   1 
ATOM   2286 C  CA  . GLN A 1 340 ? -19.357 -30.878 -17.380 0.50 54.46  ? 603  GLN A CA  1 
ATOM   2287 C  C   . GLN A 1 340 ? -19.575 -31.074 -18.889 0.50 51.29  ? 603  GLN A C   1 
ATOM   2288 O  O   . GLN A 1 340 ? -18.591 -31.345 -19.589 0.50 47.71  ? 603  GLN A O   1 
ATOM   2289 C  CB  . GLN A 1 340 ? -19.707 -32.130 -16.571 0.50 58.62  ? 603  GLN A CB  1 
ATOM   2290 C  CG  . GLN A 1 340 ? -21.188 -32.255 -16.256 0.50 65.12  ? 603  GLN A CG  1 
ATOM   2291 C  CD  . GLN A 1 340 ? -21.486 -33.467 -15.407 0.50 70.26  ? 603  GLN A CD  1 
ATOM   2292 O  OE1 . GLN A 1 340 ? -20.596 -34.031 -14.772 0.50 71.42  ? 603  GLN A OE1 1 
ATOM   2293 N  NE2 . GLN A 1 340 ? -22.745 -33.879 -15.397 0.50 72.76  ? 603  GLN A NE2 1 
ATOM   2294 N  N   . VAL A 1 341 ? -20.806 -30.922 -19.388 0.50 49.89  ? 604  VAL A N   1 
ATOM   2295 C  CA  . VAL A 1 341 ? -21.131 -31.137 -20.831 0.50 45.39  ? 604  VAL A CA  1 
ATOM   2296 C  C   . VAL A 1 341 ? -20.562 -29.978 -21.659 0.50 43.10  ? 604  VAL A C   1 
ATOM   2297 O  O   . VAL A 1 341 ? -19.951 -30.250 -22.730 0.50 37.30  ? 604  VAL A O   1 
ATOM   2298 C  CB  . VAL A 1 341 ? -22.644 -31.299 -21.061 0.50 46.65  ? 604  VAL A CB  1 
ATOM   2299 C  CG1 . VAL A 1 341 ? -22.967 -31.390 -22.545 0.50 49.67  ? 604  VAL A CG1 1 
ATOM   2300 C  CG2 . VAL A 1 341 ? -23.201 -32.507 -20.320 0.50 47.90  ? 604  VAL A CG2 1 
ATOM   2301 N  N   . VAL A 1 342 ? -20.766 -28.732 -21.211 1.00 38.79  ? 605  VAL A N   1 
ATOM   2302 C  CA  . VAL A 1 342 ? -20.126 -27.568 -21.876 1.00 39.38  ? 605  VAL A CA  1 
ATOM   2303 C  C   . VAL A 1 342 ? -18.597 -27.695 -21.732 1.00 37.28  ? 605  VAL A C   1 
ATOM   2304 O  O   . VAL A 1 342 ? -17.868 -27.464 -22.698 1.00 32.91  ? 605  VAL A O   1 
ATOM   2305 C  CB  . VAL A 1 342 ? -20.683 -26.226 -21.369 1.00 41.38  ? 605  VAL A CB  1 
ATOM   2306 C  CG1 . VAL A 1 342 ? -19.924 -25.057 -21.970 1.00 36.60  ? 605  VAL A CG1 1 
ATOM   2307 C  CG2 . VAL A 1 342 ? -22.158 -26.093 -21.709 1.00 39.41  ? 605  VAL A CG2 1 
ATOM   2308 N  N   . THR A 1 343 ? -18.104 -28.078 -20.570 1.00 34.45  ? 606  THR A N   1 
ATOM   2309 C  CA  . THR A 1 343 ? -16.652 -28.314 -20.353 1.00 35.88  ? 606  THR A CA  1 
ATOM   2310 C  C   . THR A 1 343 ? -16.086 -29.286 -21.399 1.00 32.97  ? 606  THR A C   1 
ATOM   2311 O  O   . THR A 1 343 ? -15.020 -29.015 -21.944 1.00 33.12  ? 606  THR A O   1 
ATOM   2312 C  CB  . THR A 1 343 ? -16.371 -28.829 -18.941 1.00 38.35  ? 606  THR A CB  1 
ATOM   2313 O  OG1 . THR A 1 343 ? -16.641 -27.727 -18.075 1.00 38.39  ? 606  THR A OG1 1 
ATOM   2314 C  CG2 . THR A 1 343 ? -14.961 -29.367 -18.746 1.00 43.55  ? 606  THR A CG2 1 
ATOM   2315 N  N   . TYR A 1 344 ? -16.790 -30.394 -21.659 0.50 31.16  ? 607  TYR A N   1 
ATOM   2316 C  CA  . TYR A 1 344 ? -16.335 -31.431 -22.612 0.50 30.95  ? 607  TYR A CA  1 
ATOM   2317 C  C   . TYR A 1 344 ? -16.206 -30.814 -24.010 0.50 29.66  ? 607  TYR A C   1 
ATOM   2318 O  O   . TYR A 1 344 ? -15.174 -31.048 -24.655 0.50 28.80  ? 607  TYR A O   1 
ATOM   2319 C  CB  . TYR A 1 344 ? -17.251 -32.654 -22.616 0.50 30.38  ? 607  TYR A CB  1 
ATOM   2320 C  CG  . TYR A 1 344 ? -16.850 -33.691 -23.633 0.50 29.27  ? 607  TYR A CG  1 
ATOM   2321 C  CD1 . TYR A 1 344 ? -15.751 -34.509 -23.416 0.50 29.12  ? 607  TYR A CD1 1 
ATOM   2322 C  CD2 . TYR A 1 344 ? -17.550 -33.848 -24.816 0.50 28.97  ? 607  TYR A CD2 1 
ATOM   2323 C  CE1 . TYR A 1 344 ? -15.369 -35.468 -24.342 0.50 28.95  ? 607  TYR A CE1 1 
ATOM   2324 C  CE2 . TYR A 1 344 ? -17.189 -34.810 -25.747 0.50 29.36  ? 607  TYR A CE2 1 
ATOM   2325 C  CZ  . TYR A 1 344 ? -16.083 -35.613 -25.519 0.50 28.57  ? 607  TYR A CZ  1 
ATOM   2326 O  OH  . TYR A 1 344 ? -15.714 -36.550 -26.452 0.50 28.96  ? 607  TYR A OH  1 
ATOM   2327 N  N   . GLY A 1 345 ? -17.212 -30.059 -24.459 1.00 28.18  ? 608  GLY A N   1 
ATOM   2328 C  CA  . GLY A 1 345 ? -17.200 -29.460 -25.811 1.00 29.64  ? 608  GLY A CA  1 
ATOM   2329 C  C   . GLY A 1 345 ? -16.109 -28.390 -25.962 1.00 26.53  ? 608  GLY A C   1 
ATOM   2330 O  O   . GLY A 1 345 ? -15.385 -28.377 -26.955 1.00 31.80  ? 608  GLY A O   1 
ATOM   2331 N  N   . LEU A 1 346 ? -15.940 -27.528 -24.987 1.00 27.69  ? 609  LEU A N   1 
ATOM   2332 C  CA  . LEU A 1 346 ? -14.924 -26.465 -25.118 1.00 34.18  ? 609  LEU A CA  1 
ATOM   2333 C  C   . LEU A 1 346 ? -13.483 -27.015 -24.921 1.00 28.47  ? 609  LEU A C   1 
ATOM   2334 O  O   . LEU A 1 346 ? -12.558 -26.491 -25.551 1.00 30.47  ? 609  LEU A O   1 
ATOM   2335 C  CB  . LEU A 1 346 ? -15.265 -25.392 -24.090 1.00 30.57  ? 609  LEU A CB  1 
ATOM   2336 C  CG  . LEU A 1 346 ? -16.531 -24.594 -24.369 1.00 31.01  ? 609  LEU A CG  1 
ATOM   2337 C  CD1 . LEU A 1 346 ? -16.664 -23.491 -23.340 1.00 36.76  ? 609  LEU A CD1 1 
ATOM   2338 C  CD2 . LEU A 1 346 ? -16.516 -24.033 -25.765 1.00 30.39  ? 609  LEU A CD2 1 
ATOM   2339 N  N   . ASN A 1 347 ? -13.307 -28.005 -24.051 1.00 28.95  ? 610  ASN A N   1 
ATOM   2340 C  CA  . ASN A 1 347 ? -12.032 -28.762 -23.932 1.00 28.59  ? 610  ASN A CA  1 
ATOM   2341 C  C   . ASN A 1 347 ? -11.747 -29.418 -25.276 1.00 26.28  ? 610  ASN A C   1 
ATOM   2342 O  O   . ASN A 1 347 ? -10.629 -29.277 -25.722 1.00 26.68  ? 610  ASN A O   1 
ATOM   2343 C  CB  . ASN A 1 347 ? -12.054 -29.798 -22.813 1.00 25.87  ? 610  ASN A CB  1 
ATOM   2344 C  CG  . ASN A 1 347 ? -11.875 -29.194 -21.445 1.00 29.08  ? 610  ASN A CG  1 
ATOM   2345 O  OD1 . ASN A 1 347 ? -11.591 -28.012 -21.309 1.00 30.12  ? 610  ASN A OD1 1 
ATOM   2346 N  ND2 . ASN A 1 347 ? -12.074 -30.002 -20.430 1.00 33.16  ? 610  ASN A ND2 1 
ATOM   2347 N  N   . THR A 1 348 ? -12.729 -30.055 -25.950 1.00 26.45  ? 611  THR A N   1 
ATOM   2348 C  CA  . THR A 1 348 ? -12.468 -30.640 -27.295 1.00 23.88  ? 611  THR A CA  1 
ATOM   2349 C  C   . THR A 1 348 ? -11.991 -29.563 -28.268 1.00 25.90  ? 611  THR A C   1 
ATOM   2350 O  O   . THR A 1 348 ? -11.038 -29.783 -29.009 1.00 26.32  ? 611  THR A O   1 
ATOM   2351 C  CB  . THR A 1 348 ? -13.668 -31.376 -27.845 1.00 22.44  ? 611  THR A CB  1 
ATOM   2352 O  OG1 . THR A 1 348 ? -14.092 -32.324 -26.869 1.00 25.65  ? 611  THR A OG1 1 
ATOM   2353 C  CG2 . THR A 1 348 ? -13.346 -32.005 -29.148 1.00 22.19  ? 611  THR A CG2 1 
ATOM   2354 N  N   . PHE A 1 349 ? -12.664 -28.416 -28.273 1.00 28.30  ? 612  PHE A N   1 
ATOM   2355 C  CA  . PHE A 1 349 ? -12.391 -27.313 -29.211 1.00 29.51  ? 612  PHE A CA  1 
ATOM   2356 C  C   . PHE A 1 349 ? -10.944 -26.848 -29.044 1.00 25.73  ? 612  PHE A C   1 
ATOM   2357 O  O   . PHE A 1 349 ? -10.171 -26.752 -30.013 1.00 26.42  ? 612  PHE A O   1 
ATOM   2358 C  CB  . PHE A 1 349 ? -13.364 -26.165 -28.920 1.00 29.09  ? 612  PHE A CB  1 
ATOM   2359 C  CG  . PHE A 1 349 ? -13.059 -24.982 -29.768 1.00 27.74  ? 612  PHE A CG  1 
ATOM   2360 C  CD1 . PHE A 1 349 ? -13.580 -24.890 -31.049 1.00 34.20  ? 612  PHE A CD1 1 
ATOM   2361 C  CD2 . PHE A 1 349 ? -12.250 -23.971 -29.291 1.00 28.28  ? 612  PHE A CD2 1 
ATOM   2362 C  CE1 . PHE A 1 349 ? -13.282 -23.799 -31.857 1.00 30.49  ? 612  PHE A CE1 1 
ATOM   2363 C  CE2 . PHE A 1 349 ? -11.974 -22.870 -30.094 1.00 35.19  ? 612  PHE A CE2 1 
ATOM   2364 C  CZ  . PHE A 1 349 ? -12.459 -22.796 -31.371 1.00 32.98  ? 612  PHE A CZ  1 
ATOM   2365 N  N   . THR A 1 350 ? -10.605 -26.505 -27.828 1.00 23.64  ? 613  THR A N   1 
ATOM   2366 C  CA  . THR A 1 350 ? -9.304  -25.889 -27.492 1.00 32.13  ? 613  THR A CA  1 
ATOM   2367 C  C   . THR A 1 350 ? -8.199  -26.951 -27.666 1.00 29.93  ? 613  THR A C   1 
ATOM   2368 O  O   . THR A 1 350 ? -7.110  -26.598 -28.048 1.00 27.62  ? 613  THR A O   1 
ATOM   2369 C  CB  . THR A 1 350 ? -9.368  -25.283 -26.093 1.00 32.42  ? 613  THR A CB  1 
ATOM   2370 O  OG1 . THR A 1 350 ? -10.247 -24.149 -26.122 1.00 32.29  ? 613  THR A OG1 1 
ATOM   2371 C  CG2 . THR A 1 350 ? -8.011  -24.829 -25.604 1.00 38.45  ? 613  THR A CG2 1 
ATOM   2372 N  N   . ASN A 1 351 ? -8.472  -28.230 -27.415 1.00 27.42  ? 614  ASN A N   1 
ATOM   2373 C  CA  . ASN A 1 351 ? -7.471  -29.312 -27.655 1.00 25.80  ? 614  ASN A CA  1 
ATOM   2374 C  C   . ASN A 1 351 ? -7.281  -29.467 -29.161 1.00 28.35  ? 614  ASN A C   1 
ATOM   2375 O  O   . ASN A 1 351 ? -6.152  -29.629 -29.614 1.00 25.96  ? 614  ASN A O   1 
ATOM   2376 C  CB  . ASN A 1 351 ? -7.914  -30.592 -26.937 1.00 26.21  ? 614  ASN A CB  1 
ATOM   2377 C  CG  . ASN A 1 351 ? -6.749  -31.529 -26.620 1.00 31.29  ? 614  ASN A CG  1 
ATOM   2378 O  OD1 . ASN A 1 351 ? -5.587  -31.181 -26.867 1.00 29.86  ? 614  ASN A OD1 1 
ATOM   2379 N  ND2 . ASN A 1 351 ? -7.051  -32.723 -26.112 1.00 27.84  ? 614  ASN A ND2 1 
ATOM   2380 N  N   . MET A 1 352 ? -8.356  -29.321 -29.945 1.00 24.77  ? 615  MET A N   1 
ATOM   2381 C  CA  . MET A 1 352 ? -8.222  -29.456 -31.401 1.00 25.76  ? 615  MET A CA  1 
ATOM   2382 C  C   . MET A 1 352 ? -7.304  -28.301 -31.844 1.00 27.82  ? 615  MET A C   1 
ATOM   2383 O  O   . MET A 1 352 ? -6.450  -28.512 -32.744 1.00 29.39  ? 615  MET A O   1 
ATOM   2384 C  CB  . MET A 1 352 ? -9.592  -29.352 -32.094 1.00 26.61  ? 615  MET A CB  1 
ATOM   2385 C  CG  . MET A 1 352 ? -10.383 -30.607 -31.987 1.00 30.59  ? 615  MET A CG  1 
ATOM   2386 S  SD  . MET A 1 352 ? -12.101 -30.317 -32.624 1.00 31.11  ? 615  MET A SD  1 
ATOM   2387 C  CE  . MET A 1 352 ? -11.859 -30.129 -34.360 1.00 27.81  ? 615  MET A CE  1 
ATOM   2388 N  N   . GLU A 1 353 ? -7.579  -27.121 -31.321 1.00 26.62  ? 616  GLU A N   1 
ATOM   2389 C  CA  . GLU A 1 353 ? -6.822  -25.885 -31.719 1.00 27.61  ? 616  GLU A CA  1 
ATOM   2390 C  C   . GLU A 1 353 ? -5.316  -26.083 -31.394 1.00 28.73  ? 616  GLU A C   1 
ATOM   2391 O  O   . GLU A 1 353 ? -4.482  -25.868 -32.247 1.00 28.67  ? 616  GLU A O   1 
ATOM   2392 C  CB  . GLU A 1 353 ? -7.366  -24.748 -30.893 1.00 28.24  ? 616  GLU A CB  1 
ATOM   2393 C  CG  . GLU A 1 353 ? -6.817  -23.395 -31.246 1.00 34.64  ? 616  GLU A CG  1 
ATOM   2394 C  CD  . GLU A 1 353 ? -7.083  -22.423 -30.115 1.00 34.03  ? 616  GLU A CD  1 
ATOM   2395 O  OE1 . GLU A 1 353 ? -8.278  -22.015 -29.925 1.00 36.94  ? 616  GLU A OE1 1 
ATOM   2396 O  OE2 . GLU A 1 353 ? -6.104  -22.140 -29.353 1.00 34.87  ? 616  GLU A OE2 1 
ATOM   2397 N  N   . ALA A 1 354 ? -5.004  -26.429 -30.153 1.00 29.36  ? 617  ALA A N   1 
ATOM   2398 C  CA  . ALA A 1 354 ? -3.639  -26.663 -29.636 1.00 29.78  ? 617  ALA A CA  1 
ATOM   2399 C  C   . ALA A 1 354 ? -2.900  -27.713 -30.466 1.00 29.99  ? 617  ALA A C   1 
ATOM   2400 O  O   . ALA A 1 354 ? -1.702  -27.522 -30.776 1.00 28.19  ? 617  ALA A O   1 
ATOM   2401 C  CB  . ALA A 1 354 ? -3.737  -27.087 -28.214 1.00 27.75  ? 617  ALA A CB  1 
ATOM   2402 N  N   . GLN A 1 355 ? -3.563  -28.824 -30.806 1.00 27.24  ? 618  GLN A N   1 
ATOM   2403 C  CA  . GLN A 1 355 ? -2.878  -29.869 -31.573 1.00 26.49  ? 618  GLN A CA  1 
ATOM   2404 C  C   . GLN A 1 355 ? -2.664  -29.462 -33.038 1.00 27.73  ? 618  GLN A C   1 
ATOM   2405 O  O   . GLN A 1 355 ? -1.678  -29.926 -33.643 1.00 28.74  ? 618  GLN A O   1 
ATOM   2406 C  CB  . GLN A 1 355 ? -3.653  -31.176 -31.469 1.00 26.53  ? 618  GLN A CB  1 
ATOM   2407 C  CG  . GLN A 1 355 ? -3.884  -31.662 -30.057 1.00 24.51  ? 618  GLN A CG  1 
ATOM   2408 C  CD  . GLN A 1 355 ? -2.613  -31.801 -29.269 1.00 26.50  ? 618  GLN A CD  1 
ATOM   2409 O  OE1 . GLN A 1 355 ? -1.561  -32.203 -29.751 1.00 28.23  ? 618  GLN A OE1 1 
ATOM   2410 N  NE2 . GLN A 1 355 ? -2.733  -31.561 -28.002 1.00 26.22  ? 618  GLN A NE2 1 
ATOM   2411 N  N   . LEU A 1 356 ? -3.528  -28.636 -33.667 1.00 30.60  ? 619  LEU A N   1 
ATOM   2412 C  CA  . LEU A 1 356 ? -3.277  -28.168 -35.044 1.00 28.02  ? 619  LEU A CA  1 
ATOM   2413 C  C   . LEU A 1 356 ? -2.019  -27.277 -34.996 1.00 30.84  ? 619  LEU A C   1 
ATOM   2414 O  O   . LEU A 1 356 ? -1.242  -27.325 -35.920 1.00 31.47  ? 619  LEU A O   1 
ATOM   2415 C  CB  . LEU A 1 356 ? -4.458  -27.308 -35.560 1.00 30.35  ? 619  LEU A CB  1 
ATOM   2416 C  CG  . LEU A 1 356 ? -5.651  -28.042 -36.156 1.00 30.95  ? 619  LEU A CG  1 
ATOM   2417 C  CD1 . LEU A 1 356 ? -6.705  -27.047 -36.534 1.00 32.41  ? 619  LEU A CD1 1 
ATOM   2418 C  CD2 . LEU A 1 356 ? -5.258  -28.864 -37.368 1.00 34.29  ? 619  LEU A CD2 1 
ATOM   2419 N  N   . ILE A 1 357 ? -1.901  -26.452 -33.976 1.00 26.17  ? 620  ILE A N   1 
ATOM   2420 C  CA  . ILE A 1 357 ? -0.731  -25.537 -33.787 1.00 33.20  ? 620  ILE A CA  1 
ATOM   2421 C  C   . ILE A 1 357 ? 0.543   -26.356 -33.542 1.00 34.54  ? 620  ILE A C   1 
ATOM   2422 O  O   . ILE A 1 357 ? 1.511   -26.118 -34.259 1.00 31.51  ? 620  ILE A O   1 
ATOM   2423 C  CB  . ILE A 1 357 ? -0.997  -24.548 -32.665 1.00 30.94  ? 620  ILE A CB  1 
ATOM   2424 C  CG1 . ILE A 1 357 ? -2.121  -23.590 -33.081 1.00 30.79  ? 620  ILE A CG1 1 
ATOM   2425 C  CG2 . ILE A 1 357 ? 0.256   -23.754 -32.327 1.00 37.62  ? 620  ILE A CG2 1 
ATOM   2426 C  CD1 . ILE A 1 357 ? -2.690  -22.812 -31.927 1.00 33.40  ? 620  ILE A CD1 1 
ATOM   2427 N  N   . ARG A 1 358 ? 0.463   -27.417 -32.737 1.00 31.94  ? 621  ARG A N   1 
ATOM   2428 C  CA  . ARG A 1 358 ? 1.619   -28.311 -32.559 1.00 29.91  ? 621  ARG A CA  1 
ATOM   2429 C  C   . ARG A 1 358 ? 1.961   -28.963 -33.891 1.00 32.62  ? 621  ARG A C   1 
ATOM   2430 O  O   . ARG A 1 358 ? 3.190   -28.979 -34.207 1.00 31.88  ? 621  ARG A O   1 
ATOM   2431 C  CB  . ARG A 1 358 ? 1.427   -29.304 -31.415 1.00 33.39  ? 621  ARG A CB  1 
ATOM   2432 C  CG  . ARG A 1 358 ? 2.617   -30.246 -31.333 1.00 32.52  ? 621  ARG A CG  1 
ATOM   2433 C  CD  . ARG A 1 358 ? 2.638   -31.036 -30.061 1.00 33.27  ? 621  ARG A CD  1 
ATOM   2434 N  NE  . ARG A 1 358 ? 3.778   -31.964 -30.042 1.00 31.93  ? 621  ARG A NE  1 
ATOM   2435 C  CZ  . ARG A 1 358 ? 3.958   -32.925 -29.122 1.00 32.73  ? 621  ARG A CZ  1 
ATOM   2436 N  NH1 . ARG A 1 358 ? 3.009   -33.228 -28.253 1.00 27.33  ? 621  ARG A NH1 1 
ATOM   2437 N  NH2 . ARG A 1 358 ? 5.071   -33.658 -29.153 1.00 35.12  ? 621  ARG A NH2 1 
ATOM   2438 N  N   . GLN A 1 359 ? 0.975   -29.400 -34.693 1.00 26.36  ? 622  GLN A N   1 
ATOM   2439 C  CA  . GLN A 1 359 ? 1.229   -29.885 -36.075 1.00 28.27  ? 622  GLN A CA  1 
ATOM   2440 C  C   . GLN A 1 359 ? 1.904   -28.754 -36.905 1.00 32.70  ? 622  GLN A C   1 
ATOM   2441 O  O   . GLN A 1 359 ? 2.839   -29.067 -37.695 1.00 38.74  ? 622  GLN A O   1 
ATOM   2442 C  CB  . GLN A 1 359 ? -0.010  -30.427 -36.797 1.00 25.86  ? 622  GLN A CB  1 
ATOM   2443 C  CG  . GLN A 1 359 ? -0.547  -31.739 -36.219 1.00 25.45  ? 622  GLN A CG  1 
ATOM   2444 C  CD  . GLN A 1 359 ? -1.505  -32.403 -37.150 1.00 25.45  ? 622  GLN A CD  1 
ATOM   2445 O  OE1 . GLN A 1 359 ? -1.175  -32.925 -38.231 1.00 28.56  ? 622  GLN A OE1 1 
ATOM   2446 N  NE2 . GLN A 1 359 ? -2.746  -32.476 -36.675 1.00 29.70  ? 622  GLN A NE2 1 
ATOM   2447 N  N   . MET A 1 360 ? 1.433   -27.524 -36.845 1.00 31.36  ? 623  MET A N   1 
ATOM   2448 C  CA  . MET A 1 360 ? 2.028   -26.410 -37.665 1.00 32.87  ? 623  MET A CA  1 
ATOM   2449 C  C   . MET A 1 360 ? 3.514   -26.251 -37.273 1.00 33.01  ? 623  MET A C   1 
ATOM   2450 O  O   . MET A 1 360 ? 4.350   -26.134 -38.179 1.00 35.44  ? 623  MET A O   1 
ATOM   2451 C  CB  . MET A 1 360 ? 1.342   -25.067 -37.384 1.00 34.99  ? 623  MET A CB  1 
ATOM   2452 C  CG  . MET A 1 360 ? -0.014  -24.885 -38.023 1.00 39.69  ? 623  MET A CG  1 
ATOM   2453 S  SD  . MET A 1 360 ? -0.640  -23.319 -37.401 1.00 42.20  ? 623  MET A SD  1 
ATOM   2454 C  CE  . MET A 1 360 ? -2.410  -23.597 -37.519 1.00 44.71  ? 623  MET A CE  1 
ATOM   2455 N  N   . GLU A 1 361 ? 3.798   -26.255 -35.976 1.00 30.39  ? 624  GLU A N   1 
ATOM   2456 C  CA  . GLU A 1 361 ? 5.191   -26.187 -35.461 1.00 34.39  ? 624  GLU A CA  1 
ATOM   2457 C  C   . GLU A 1 361 ? 6.043   -27.296 -36.062 1.00 39.83  ? 624  GLU A C   1 
ATOM   2458 O  O   . GLU A 1 361 ? 7.121   -26.973 -36.629 1.00 38.19  ? 624  GLU A O   1 
ATOM   2459 C  CB  . GLU A 1 361 ? 5.230   -26.235 -33.944 1.00 33.47  ? 624  GLU A CB  1 
ATOM   2460 C  CG  . GLU A 1 361 ? 6.586   -25.809 -33.415 1.00 32.85  ? 624  GLU A CG  1 
ATOM   2461 C  CD  . GLU A 1 361 ? 6.674   -25.546 -31.936 1.00 36.36  ? 624  GLU A CD  1 
ATOM   2462 O  OE1 . GLU A 1 361 ? 7.812   -25.574 -31.393 1.00 43.60  ? 624  GLU A OE1 1 
ATOM   2463 O  OE2 . GLU A 1 361 ? 5.628   -25.275 -31.313 1.00 37.51  ? 624  GLU A OE2 1 
ATOM   2464 N  N   . GLY A 1 362 ? 5.589   -28.551 -36.033 1.00 34.61  ? 625  GLY A N   1 
ATOM   2465 C  CA  . GLY A 1 362 ? 6.383   -29.663 -36.576 1.00 34.39  ? 625  GLY A CA  1 
ATOM   2466 C  C   . GLY A 1 362 ? 6.648   -29.456 -38.058 1.00 39.57  ? 625  GLY A C   1 
ATOM   2467 O  O   . GLY A 1 362 ? 7.696   -29.864 -38.534 1.00 41.65  ? 625  GLY A O   1 
ATOM   2468 N  N   . GLU A 1 363 ? 5.679   -28.897 -38.768 1.00 32.52  ? 626  GLU A N   1 
ATOM   2469 C  CA  . GLU A 1 363 ? 5.742   -28.741 -40.237 1.00 30.73  ? 626  GLU A CA  1 
ATOM   2470 C  C   . GLU A 1 363 ? 6.554   -27.481 -40.610 1.00 31.85  ? 626  GLU A C   1 
ATOM   2471 O  O   . GLU A 1 363 ? 6.679   -27.243 -41.779 1.00 35.32  ? 626  GLU A O   1 
ATOM   2472 C  CB  . GLU A 1 363 ? 4.343   -28.716 -40.834 1.00 30.26  ? 626  GLU A CB  1 
ATOM   2473 C  CG  . GLU A 1 363 ? 3.780   -30.148 -40.910 1.00 34.02  ? 626  GLU A CG  1 
ATOM   2474 C  CD  . GLU A 1 363 ? 2.390   -30.323 -41.478 1.00 42.31  ? 626  GLU A CD  1 
ATOM   2475 O  OE1 . GLU A 1 363 ? 2.169   -29.814 -42.596 1.00 33.25  ? 626  GLU A OE1 1 
ATOM   2476 O  OE2 . GLU A 1 363 ? 1.539   -30.990 -40.792 1.00 30.88  ? 626  GLU A OE2 1 
ATOM   2477 N  N   . GLY A 1 364 ? 7.005   -26.693 -39.657 1.00 30.75  ? 627  GLY A N   1 
ATOM   2478 C  CA  . GLY A 1 364 ? 7.798   -25.486 -39.953 1.00 38.08  ? 627  GLY A CA  1 
ATOM   2479 C  C   . GLY A 1 364 ? 6.960   -24.402 -40.599 1.00 46.41  ? 627  GLY A C   1 
ATOM   2480 O  O   . GLY A 1 364 ? 7.538   -23.665 -41.444 1.00 49.75  ? 627  GLY A O   1 
ATOM   2481 N  N   . VAL A 1 365 ? 5.672   -24.255 -40.210 1.00 37.93  ? 628  VAL A N   1 
ATOM   2482 C  CA  . VAL A 1 365 ? 4.758   -23.230 -40.806 1.00 39.79  ? 628  VAL A CA  1 
ATOM   2483 C  C   . VAL A 1 365 ? 5.162   -21.863 -40.260 1.00 41.56  ? 628  VAL A C   1 
ATOM   2484 O  O   . VAL A 1 365 ? 5.116   -20.883 -41.019 1.00 45.38  ? 628  VAL A O   1 
ATOM   2485 C  CB  . VAL A 1 365 ? 3.269   -23.548 -40.550 1.00 41.34  ? 628  VAL A CB  1 
ATOM   2486 C  CG1 . VAL A 1 365 ? 2.357   -22.444 -41.091 1.00 42.36  ? 628  VAL A CG1 1 
ATOM   2487 C  CG2 . VAL A 1 365 ? 2.881   -24.881 -41.189 1.00 43.42  ? 628  VAL A CG2 1 
ATOM   2488 N  N   . PHE A 1 366 ? 5.503   -21.808 -38.977 1.00 44.12  ? 629  PHE A N   1 
ATOM   2489 C  CA  . PHE A 1 366 ? 6.081   -20.613 -38.325 1.00 46.90  ? 629  PHE A CA  1 
ATOM   2490 C  C   . PHE A 1 366 ? 7.425   -21.024 -37.730 1.00 53.39  ? 629  PHE A C   1 
ATOM   2491 O  O   . PHE A 1 366 ? 7.622   -22.236 -37.509 1.00 53.74  ? 629  PHE A O   1 
ATOM   2492 C  CB  . PHE A 1 366 ? 5.136   -20.049 -37.271 1.00 44.37  ? 629  PHE A CB  1 
ATOM   2493 C  CG  . PHE A 1 366 ? 4.946   -20.919 -36.065 1.00 42.21  ? 629  PHE A CG  1 
ATOM   2494 C  CD1 . PHE A 1 366 ? 3.990   -21.916 -36.074 1.00 38.45  ? 629  PHE A CD1 1 
ATOM   2495 C  CD2 . PHE A 1 366 ? 5.677   -20.711 -34.910 1.00 43.06  ? 629  PHE A CD2 1 
ATOM   2496 C  CE1 . PHE A 1 366 ? 3.802   -22.711 -34.962 1.00 35.99  ? 629  PHE A CE1 1 
ATOM   2497 C  CE2 . PHE A 1 366 ? 5.498   -21.520 -33.808 1.00 44.53  ? 629  PHE A CE2 1 
ATOM   2498 C  CZ  . PHE A 1 366 ? 4.556   -22.530 -33.843 1.00 39.03  ? 629  PHE A CZ  1 
ATOM   2499 N  N   . LYS A 1 367 ? 8.320   -20.057 -37.517 1.00 55.29  ? 630  LYS A N   1 
ATOM   2500 C  CA  . LYS A 1 367 ? 9.714   -20.306 -37.074 1.00 59.42  ? 630  LYS A CA  1 
ATOM   2501 C  C   . LYS A 1 367 ? 9.812   -20.033 -35.579 1.00 46.66  ? 630  LYS A C   1 
ATOM   2502 O  O   . LYS A 1 367 ? 10.589  -20.737 -34.927 1.00 55.91  ? 630  LYS A O   1 
ATOM   2503 C  CB  . LYS A 1 367 ? 10.711  -19.470 -37.882 1.00 72.50  ? 630  LYS A CB  1 
ATOM   2504 C  CG  . LYS A 1 367 ? 12.138  -19.481 -37.340 1.00 82.06  ? 630  LYS A CG  1 
ATOM   2505 C  CD  . LYS A 1 367 ? 13.163  -18.884 -38.292 1.00 89.55  ? 630  LYS A CD  1 
ATOM   2506 C  CE  . LYS A 1 367 ? 14.421  -18.390 -37.604 1.00 95.26  ? 630  LYS A CE  1 
ATOM   2507 N  NZ  . LYS A 1 367 ? 14.173  -17.175 -36.788 1.00 102.87 ? 630  LYS A NZ  1 
ATOM   2508 N  N   . SER A 1 368 ? 9.025   -19.111 -35.027 1.00 42.50  ? 631  SER A N   1 
ATOM   2509 C  CA  . SER A 1 368 ? 9.120   -18.753 -33.586 1.00 43.62  ? 631  SER A CA  1 
ATOM   2510 C  C   . SER A 1 368 ? 7.812   -18.203 -33.012 1.00 47.60  ? 631  SER A C   1 
ATOM   2511 O  O   . SER A 1 368 ? 7.179   -17.369 -33.691 1.00 46.13  ? 631  SER A O   1 
ATOM   2512 C  CB  . SER A 1 368 ? 10.173  -17.718 -33.374 1.00 52.08  ? 631  SER A CB  1 
ATOM   2513 O  OG  . SER A 1 368 ? 10.279  -17.390 -31.991 1.00 52.26  ? 631  SER A OG  1 
ATOM   2514 N  N   . ILE A 1 369 ? 7.566   -18.522 -31.731 1.00 47.58  ? 632  ILE A N   1 
ATOM   2515 C  CA  . ILE A 1 369 ? 6.352   -18.171 -30.936 1.00 49.05  ? 632  ILE A CA  1 
ATOM   2516 C  C   . ILE A 1 369 ? 6.481   -16.775 -30.335 1.00 51.20  ? 632  ILE A C   1 
ATOM   2517 O  O   . ILE A 1 369 ? 5.513   -16.286 -29.733 1.00 51.19  ? 632  ILE A O   1 
ATOM   2518 C  CB  . ILE A 1 369 ? 6.088   -19.160 -29.781 1.00 47.62  ? 632  ILE A CB  1 
ATOM   2519 C  CG1 . ILE A 1 369 ? 7.197   -19.093 -28.739 1.00 42.91  ? 632  ILE A CG1 1 
ATOM   2520 C  CG2 . ILE A 1 369 ? 5.847   -20.582 -30.276 1.00 47.21  ? 632  ILE A CG2 1 
ATOM   2521 C  CD1 . ILE A 1 369 ? 6.888   -19.776 -27.456 1.00 48.76  ? 632  ILE A CD1 1 
ATOM   2522 N  N   . GLN A 1 370 ? 7.625   -16.130 -30.572 0.50 54.96  ? 633  GLN A N   1 
ATOM   2523 C  CA  . GLN A 1 370 ? 7.883   -14.790 -29.991 0.50 57.50  ? 633  GLN A CA  1 
ATOM   2524 C  C   . GLN A 1 370 ? 7.028   -13.762 -30.725 0.50 53.04  ? 633  GLN A C   1 
ATOM   2525 O  O   . GLN A 1 370 ? 6.430   -12.909 -30.054 0.50 49.64  ? 633  GLN A O   1 
ATOM   2526 C  CB  . GLN A 1 370 ? 9.370   -14.474 -30.115 0.50 60.50  ? 633  GLN A CB  1 
ATOM   2527 C  CG  . GLN A 1 370 ? 9.925   -13.704 -28.927 0.50 66.18  ? 633  GLN A CG  1 
ATOM   2528 C  CD  . GLN A 1 370 ? 10.040  -14.562 -27.691 0.50 65.90  ? 633  GLN A CD  1 
ATOM   2529 O  OE1 . GLN A 1 370 ? 9.767   -15.759 -27.712 0.50 70.04  ? 633  GLN A OE1 1 
ATOM   2530 N  NE2 . GLN A 1 370 ? 10.464  -13.949 -26.599 0.50 65.18  ? 633  GLN A NE2 1 
ATOM   2531 N  N   . HIS A 1 371 ? 6.999   -13.844 -32.053 0.50 53.95  ? 634  HIS A N   1 
ATOM   2532 C  CA  . HIS A 1 371 ? 6.135   -12.941 -32.852 0.50 59.42  ? 634  HIS A CA  1 
ATOM   2533 C  C   . HIS A 1 371 ? 6.007   -13.525 -34.262 0.50 57.87  ? 634  HIS A C   1 
ATOM   2534 O  O   . HIS A 1 371 ? 6.918   -14.255 -34.683 0.50 49.37  ? 634  HIS A O   1 
ATOM   2535 C  CB  . HIS A 1 371 ? 6.687   -11.509 -32.812 0.50 68.89  ? 634  HIS A CB  1 
ATOM   2536 C  CG  . HIS A 1 371 ? 6.698   -10.830 -34.141 0.50 75.08  ? 634  HIS A CG  1 
ATOM   2537 N  ND1 . HIS A 1 371 ? 7.716   -11.014 -35.057 0.50 79.40  ? 634  HIS A ND1 1 
ATOM   2538 C  CD2 . HIS A 1 371 ? 5.828   -9.969  -34.711 0.50 81.01  ? 634  HIS A CD2 1 
ATOM   2539 C  CE1 . HIS A 1 371 ? 7.469   -10.298 -36.133 0.50 81.20  ? 634  HIS A CE1 1 
ATOM   2540 N  NE2 . HIS A 1 371 ? 6.319   -9.646  -35.946 0.50 82.17  ? 634  HIS A NE2 1 
ATOM   2541 N  N   . LEU A 1 372 ? 4.903   -13.223 -34.941 0.50 59.42  ? 635  LEU A N   1 
ATOM   2542 C  CA  . LEU A 1 372 ? 4.656   -13.785 -36.288 0.50 64.18  ? 635  LEU A CA  1 
ATOM   2543 C  C   . LEU A 1 372 ? 4.839   -12.691 -37.342 0.50 66.50  ? 635  LEU A C   1 
ATOM   2544 O  O   . LEU A 1 372 ? 4.320   -11.586 -37.135 0.50 68.51  ? 635  LEU A O   1 
ATOM   2545 C  CB  . LEU A 1 372 ? 3.236   -14.362 -36.332 0.50 65.86  ? 635  LEU A CB  1 
ATOM   2546 C  CG  . LEU A 1 372 ? 3.139   -15.885 -36.261 0.50 67.34  ? 635  LEU A CG  1 
ATOM   2547 C  CD1 . LEU A 1 372 ? 3.485   -16.384 -34.866 0.50 68.27  ? 635  LEU A CD1 1 
ATOM   2548 C  CD2 . LEU A 1 372 ? 1.747   -16.350 -36.658 0.50 68.35  ? 635  LEU A CD2 1 
ATOM   2549 N  N   . THR A 1 373 ? 5.550   -13.000 -38.428 0.50 68.90  ? 636  THR A N   1 
ATOM   2550 C  CA  . THR A 1 373 ? 5.760   -12.035 -39.534 0.50 68.16  ? 636  THR A CA  1 
ATOM   2551 C  C   . THR A 1 373 ? 4.537   -12.053 -40.449 0.50 69.93  ? 636  THR A C   1 
ATOM   2552 O  O   . THR A 1 373 ? 4.007   -13.151 -40.704 0.50 65.19  ? 636  THR A O   1 
ATOM   2553 C  CB  . THR A 1 373 ? 7.020   -12.388 -40.329 0.50 69.57  ? 636  THR A CB  1 
ATOM   2554 O  OG1 . THR A 1 373 ? 6.798   -13.636 -40.987 0.50 72.17  ? 636  THR A OG1 1 
ATOM   2555 C  CG2 . THR A 1 373 ? 8.255   -12.478 -39.460 0.50 68.36  ? 636  THR A CG2 1 
ATOM   2556 N  N   . VAL A 1 374 ? 4.091   -10.881 -40.891 0.50 67.91  ? 637  VAL A N   1 
ATOM   2557 C  CA  . VAL A 1 374 ? 2.943   -10.796 -41.835 0.50 69.24  ? 637  VAL A CA  1 
ATOM   2558 C  C   . VAL A 1 374 ? 2.918   -12.033 -42.734 0.50 68.17  ? 637  VAL A C   1 
ATOM   2559 O  O   . VAL A 1 374 ? 1.866   -12.691 -42.788 0.50 67.03  ? 637  VAL A O   1 
ATOM   2560 C  CB  . VAL A 1 374 ? 3.058   -9.504  -42.669 0.50 71.31  ? 637  VAL A CB  1 
ATOM   2561 C  CG1 . VAL A 1 374 ? 2.639   -8.280  -41.872 0.50 71.44  ? 637  VAL A CG1 1 
ATOM   2562 C  CG2 . VAL A 1 374 ? 4.457   -9.322  -43.240 0.50 71.59  ? 637  VAL A CG2 1 
ATOM   2563 N  N   . THR A 1 375 ? 4.035   -12.343 -43.396 0.50 63.80  ? 638  THR A N   1 
ATOM   2564 C  CA  . THR A 1 375 ? 4.081   -13.479 -44.346 0.50 64.18  ? 638  THR A CA  1 
ATOM   2565 C  C   . THR A 1 375 ? 3.619   -14.759 -43.649 0.50 58.07  ? 638  THR A C   1 
ATOM   2566 O  O   . THR A 1 375 ? 2.843   -15.512 -44.258 0.50 55.71  ? 638  THR A O   1 
ATOM   2567 C  CB  . THR A 1 375 ? 5.500   -13.656 -44.896 0.50 65.71  ? 638  THR A CB  1 
ATOM   2568 O  OG1 . THR A 1 375 ? 6.301   -14.221 -43.858 0.50 67.88  ? 638  THR A OG1 1 
ATOM   2569 C  CG2 . THR A 1 375 ? 6.115   -12.354 -45.358 0.50 69.63  ? 638  THR A CG2 1 
ATOM   2570 N  N   . GLU A 1 376 ? 4.086   -14.981 -42.423 0.50 53.48  ? 639  GLU A N   1 
ATOM   2571 C  CA  . GLU A 1 376 ? 3.743   -16.218 -41.676 0.50 53.08  ? 639  GLU A CA  1 
ATOM   2572 C  C   . GLU A 1 376 ? 2.255   -16.222 -41.311 0.50 49.94  ? 639  GLU A C   1 
ATOM   2573 O  O   . GLU A 1 376 ? 1.651   -17.298 -41.331 0.50 42.08  ? 639  GLU A O   1 
ATOM   2574 C  CB  . GLU A 1 376 ? 4.608   -16.291 -40.422 0.50 51.35  ? 639  GLU A CB  1 
ATOM   2575 C  CG  . GLU A 1 376 ? 6.039   -16.734 -40.663 0.50 51.86  ? 639  GLU A CG  1 
ATOM   2576 C  CD  . GLU A 1 376 ? 6.922   -16.705 -39.425 0.50 50.89  ? 639  GLU A CD  1 
ATOM   2577 O  OE1 . GLU A 1 376 ? 7.864   -17.518 -39.348 0.50 54.54  ? 639  GLU A OE1 1 
ATOM   2578 O  OE2 . GLU A 1 376 ? 6.672   -15.864 -38.545 0.50 51.61  ? 639  GLU A OE2 1 
ATOM   2579 N  N   . GLU A 1 377 ? 1.700   -15.054 -40.983 0.50 53.36  ? 640  GLU A N   1 
ATOM   2580 C  CA  . GLU A 1 377 ? 0.261   -14.982 -40.631 0.50 54.16  ? 640  GLU A CA  1 
ATOM   2581 C  C   . GLU A 1 377 ? -0.527  -15.493 -41.841 0.50 55.33  ? 640  GLU A C   1 
ATOM   2582 O  O   . GLU A 1 377 ? -1.439  -16.304 -41.632 0.50 56.13  ? 640  GLU A O   1 
ATOM   2583 C  CB  . GLU A 1 377 ? -0.120  -13.577 -40.151 0.50 55.14  ? 640  GLU A CB  1 
ATOM   2584 C  CG  . GLU A 1 377 ? 0.478   -13.219 -38.803 0.50 56.72  ? 640  GLU A CG  1 
ATOM   2585 C  CD  . GLU A 1 377 ? -0.088  -11.959 -38.172 0.50 58.62  ? 640  GLU A CD  1 
ATOM   2586 O  OE1 . GLU A 1 377 ? -1.148  -11.495 -38.630 0.50 60.61  ? 640  GLU A OE1 1 
ATOM   2587 O  OE2 . GLU A 1 377 ? 0.535   -11.445 -37.223 0.50 56.86  ? 640  GLU A OE2 1 
ATOM   2588 N  N   . ILE A 1 378 ? -0.125  -15.101 -43.055 0.50 56.76  ? 641  ILE A N   1 
ATOM   2589 C  CA  . ILE A 1 378 ? -0.769  -15.574 -44.319 0.50 55.71  ? 641  ILE A CA  1 
ATOM   2590 C  C   . ILE A 1 378 ? -0.462  -17.061 -44.525 0.50 49.26  ? 641  ILE A C   1 
ATOM   2591 O  O   . ILE A 1 378 ? -1.357  -17.793 -44.965 0.50 50.35  ? 641  ILE A O   1 
ATOM   2592 C  CB  . ILE A 1 378 ? -0.240  -14.730 -45.494 0.50 56.54  ? 641  ILE A CB  1 
ATOM   2593 C  CG1 . ILE A 1 378 ? -0.596  -15.355 -46.844 0.50 56.81  ? 641  ILE A CG1 1 
ATOM   2594 C  CG2 . ILE A 1 378 ? 1.256   -14.502 -45.363 0.50 57.17  ? 641  ILE A CG2 1 
ATOM   2595 C  CD1 . ILE A 1 378 ? 0.347   -14.968 -47.954 0.50 56.75  ? 641  ILE A CD1 1 
ATOM   2596 N  N   . ALA A 1 379 ? 0.761   -17.480 -44.211 1.00 46.40  ? 642  ALA A N   1 
ATOM   2597 C  CA  . ALA A 1 379 ? 1.193   -18.887 -44.353 1.00 47.04  ? 642  ALA A CA  1 
ATOM   2598 C  C   . ALA A 1 379 ? 0.365   -19.788 -43.422 1.00 37.77  ? 642  ALA A C   1 
ATOM   2599 O  O   . ALA A 1 379 ? -0.134  -20.804 -43.905 1.00 37.52  ? 642  ALA A O   1 
ATOM   2600 C  CB  . ALA A 1 379 ? 2.664   -18.959 -44.055 1.00 50.02  ? 642  ALA A CB  1 
ATOM   2601 N  N   . VAL A 1 380 ? 0.166   -19.366 -42.170 0.50 36.71  ? 643  VAL A N   1 
ATOM   2602 C  CA  . VAL A 1 380 ? -0.679  -20.138 -41.213 0.50 39.30  ? 643  VAL A CA  1 
ATOM   2603 C  C   . VAL A 1 380 ? -2.114  -20.198 -41.746 0.50 38.33  ? 643  VAL A C   1 
ATOM   2604 O  O   . VAL A 1 380 ? -2.656  -21.304 -41.864 0.50 31.74  ? 643  VAL A O   1 
ATOM   2605 C  CB  . VAL A 1 380 ? -0.644  -19.514 -39.804 0.50 40.71  ? 643  VAL A CB  1 
ATOM   2606 C  CG1 . VAL A 1 380 ? -1.738  -20.073 -38.910 0.50 40.13  ? 643  VAL A CG1 1 
ATOM   2607 C  CG2 . VAL A 1 380 ? 0.721   -19.660 -39.149 0.50 42.23  ? 643  VAL A CG2 1 
ATOM   2608 N  N   . LYS A 1 381 ? -2.690  -19.041 -42.064 0.50 39.31  ? 644  LYS A N   1 
ATOM   2609 C  CA  . LYS A 1 381 ? -4.078  -18.997 -42.585 0.50 40.07  ? 644  LYS A CA  1 
ATOM   2610 C  C   . LYS A 1 381 ? -4.143  -19.890 -43.822 0.50 39.10  ? 644  LYS A C   1 
ATOM   2611 O  O   . LYS A 1 381 ? -5.113  -20.654 -43.953 0.50 38.45  ? 644  LYS A O   1 
ATOM   2612 C  CB  . LYS A 1 381 ? -4.463  -17.546 -42.889 0.50 40.74  ? 644  LYS A CB  1 
ATOM   2613 C  CG  . LYS A 1 381 ? -4.667  -16.670 -41.661 0.50 41.47  ? 644  LYS A CG  1 
ATOM   2614 C  CD  . LYS A 1 381 ? -4.314  -15.212 -41.864 0.50 41.63  ? 644  LYS A CD  1 
ATOM   2615 C  CE  . LYS A 1 381 ? -4.589  -14.381 -40.628 0.50 41.83  ? 644  LYS A CE  1 
ATOM   2616 N  NZ  . LYS A 1 381 ? -3.962  -13.041 -40.702 0.50 43.62  ? 644  LYS A NZ  1 
ATOM   2617 N  N   . ASN A 1 382 ? -3.133  -19.798 -44.687 0.50 38.17  ? 645  ASN A N   1 
ATOM   2618 C  CA  . ASN A 1 382 ? -3.177  -20.577 -45.955 0.50 38.83  ? 645  ASN A CA  1 
ATOM   2619 C  C   . ASN A 1 382 ? -3.067  -22.075 -45.668 0.50 38.66  ? 645  ASN A C   1 
ATOM   2620 O  O   . ASN A 1 382 ? -3.772  -22.847 -46.341 0.50 39.49  ? 645  ASN A O   1 
ATOM   2621 C  CB  . ASN A 1 382 ? -2.084  -20.204 -46.957 0.50 40.63  ? 645  ASN A CB  1 
ATOM   2622 C  CG  . ASN A 1 382 ? -2.430  -20.692 -48.347 0.50 39.84  ? 645  ASN A CG  1 
ATOM   2623 O  OD1 . ASN A 1 382 ? -3.571  -20.558 -48.780 0.50 44.05  ? 645  ASN A OD1 1 
ATOM   2624 N  ND2 . ASN A 1 382 ? -1.472  -21.282 -49.042 0.50 37.54  ? 645  ASN A ND2 1 
ATOM   2625 N  N   . TRP A 1 383 ? -2.181  -22.461 -44.743 1.00 42.26  ? 646  TRP A N   1 
ATOM   2626 C  CA  . TRP A 1 383 ? -2.052  -23.878 -44.262 1.00 39.82  ? 646  TRP A CA  1 
ATOM   2627 C  C   . TRP A 1 383 ? -3.447  -24.433 -43.847 1.00 34.55  ? 646  TRP A C   1 
ATOM   2628 O  O   . TRP A 1 383 ? -3.901  -25.499 -44.345 1.00 33.09  ? 646  TRP A O   1 
ATOM   2629 C  CB  . TRP A 1 383 ? -1.040  -23.885 -43.108 1.00 35.85  ? 646  TRP A CB  1 
ATOM   2630 C  CG  . TRP A 1 383 ? -0.629  -25.253 -42.643 1.00 41.55  ? 646  TRP A CG  1 
ATOM   2631 C  CD1 . TRP A 1 383 ? 0.359   -26.062 -43.134 1.00 41.64  ? 646  TRP A CD1 1 
ATOM   2632 C  CD2 . TRP A 1 383 ? -1.217  -25.973 -41.550 1.00 37.63  ? 646  TRP A CD2 1 
ATOM   2633 N  NE1 . TRP A 1 383 ? 0.472   -27.206 -42.388 1.00 40.11  ? 646  TRP A NE1 1 
ATOM   2634 C  CE2 . TRP A 1 383 ? -0.471  -27.168 -41.395 1.00 37.61  ? 646  TRP A CE2 1 
ATOM   2635 C  CE3 . TRP A 1 383 ? -2.263  -25.689 -40.668 1.00 34.70  ? 646  TRP A CE3 1 
ATOM   2636 C  CZ2 . TRP A 1 383 ? -0.806  -28.111 -40.428 1.00 31.66  ? 646  TRP A CZ2 1 
ATOM   2637 C  CZ3 . TRP A 1 383 ? -2.577  -26.614 -39.694 1.00 36.04  ? 646  TRP A CZ3 1 
ATOM   2638 C  CH2 . TRP A 1 383 ? -1.841  -27.794 -39.573 1.00 33.10  ? 646  TRP A CH2 1 
ATOM   2639 N  N   . LEU A 1 384 ? -4.170  -23.683 -43.019 0.50 35.52  ? 647  LEU A N   1 
ATOM   2640 C  CA  . LEU A 1 384 ? -5.535  -24.052 -42.548 0.50 36.90  ? 647  LEU A CA  1 
ATOM   2641 C  C   . LEU A 1 384 ? -6.473  -24.289 -43.746 0.50 36.96  ? 647  LEU A C   1 
ATOM   2642 O  O   . LEU A 1 384 ? -6.962  -25.431 -43.900 0.50 32.51  ? 647  LEU A O   1 
ATOM   2643 C  CB  . LEU A 1 384 ? -6.037  -22.941 -41.621 0.50 35.61  ? 647  LEU A CB  1 
ATOM   2644 C  CG  . LEU A 1 384 ? -5.300  -22.838 -40.288 0.50 35.47  ? 647  LEU A CG  1 
ATOM   2645 C  CD1 . LEU A 1 384 ? -5.770  -21.633 -39.500 0.50 34.73  ? 647  LEU A CD1 1 
ATOM   2646 C  CD2 . LEU A 1 384 ? -5.474  -24.105 -39.459 0.50 37.56  ? 647  LEU A CD2 1 
ATOM   2647 N  N   . VAL A 1 385 ? -6.703  -23.268 -44.581 0.50 37.23  ? 648  VAL A N   1 
ATOM   2648 C  CA  . VAL A 1 385 ? -7.623  -23.348 -45.756 0.50 38.97  ? 648  VAL A CA  1 
ATOM   2649 C  C   . VAL A 1 385 ? -7.202  -24.527 -46.635 0.50 38.85  ? 648  VAL A C   1 
ATOM   2650 O  O   . VAL A 1 385 ? -8.088  -25.267 -47.081 0.50 44.15  ? 648  VAL A O   1 
ATOM   2651 C  CB  . VAL A 1 385 ? -7.639  -22.030 -46.557 0.50 40.37  ? 648  VAL A CB  1 
ATOM   2652 C  CG1 . VAL A 1 385 ? -8.751  -22.004 -47.597 0.50 39.28  ? 648  VAL A CG1 1 
ATOM   2653 C  CG2 . VAL A 1 385 ? -7.736  -20.824 -45.633 0.50 41.43  ? 648  VAL A CG2 1 
ATOM   2654 N  N   . ARG A 1 386 ? -5.895  -24.699 -46.851 0.50 42.86  ? 649  ARG A N   1 
ATOM   2655 C  CA  . ARG A 1 386 ? -5.314  -25.704 -47.782 0.50 44.15  ? 649  ARG A CA  1 
ATOM   2656 C  C   . ARG A 1 386 ? -5.366  -27.113 -47.161 0.50 43.15  ? 649  ARG A C   1 
ATOM   2657 O  O   . ARG A 1 386 ? -5.861  -28.036 -47.847 0.50 42.04  ? 649  ARG A O   1 
ATOM   2658 C  CB  . ARG A 1 386 ? -3.881  -25.292 -48.146 0.50 52.65  ? 649  ARG A CB  1 
ATOM   2659 C  CG  . ARG A 1 386 ? -3.119  -26.305 -48.994 0.50 59.45  ? 649  ARG A CG  1 
ATOM   2660 C  CD  . ARG A 1 386 ? -1.678  -25.903 -49.321 0.50 64.42  ? 649  ARG A CD  1 
ATOM   2661 N  NE  . ARG A 1 386 ? -0.641  -26.492 -48.465 0.50 66.37  ? 649  ARG A NE  1 
ATOM   2662 C  CZ  . ARG A 1 386 ? 0.118   -25.815 -47.598 0.50 63.91  ? 649  ARG A CZ  1 
ATOM   2663 N  NH1 . ARG A 1 386 ? -0.035  -24.510 -47.450 0.50 62.36  ? 649  ARG A NH1 1 
ATOM   2664 N  NH2 . ARG A 1 386 ? 1.034   -26.445 -46.880 0.50 64.17  ? 649  ARG A NH2 1 
ATOM   2665 N  N   . VAL A 1 387 ? -4.867  -27.287 -45.929 1.00 38.92  ? 650  VAL A N   1 
ATOM   2666 C  CA  . VAL A 1 387 ? -4.697  -28.667 -45.338 1.00 43.77  ? 650  VAL A CA  1 
ATOM   2667 C  C   . VAL A 1 387 ? -5.388  -28.863 -43.977 1.00 38.93  ? 650  VAL A C   1 
ATOM   2668 O  O   . VAL A 1 387 ? -5.294  -30.013 -43.482 1.00 38.20  ? 650  VAL A O   1 
ATOM   2669 C  CB  . VAL A 1 387 ? -3.208  -29.081 -45.252 1.00 36.18  ? 650  VAL A CB  1 
ATOM   2670 C  CG1 . VAL A 1 387 ? -2.573  -29.234 -46.634 1.00 41.82  ? 650  VAL A CG1 1 
ATOM   2671 C  CG2 . VAL A 1 387 ? -2.403  -28.166 -44.345 1.00 37.70  ? 650  VAL A CG2 1 
ATOM   2672 N  N   . GLY A 1 388 ? -5.999  -27.827 -43.403 1.00 35.84  ? 651  GLY A N   1 
ATOM   2673 C  CA  . GLY A 1 388 ? -6.599  -27.829 -42.049 1.00 34.43  ? 651  GLY A CA  1 
ATOM   2674 C  C   . GLY A 1 388 ? -7.495  -29.050 -41.823 1.00 34.93  ? 651  GLY A C   1 
ATOM   2675 O  O   . GLY A 1 388 ? -7.321  -29.764 -40.801 1.00 34.12  ? 651  GLY A O   1 
ATOM   2676 N  N   . ARG A 1 389 ? -8.368  -29.364 -42.783 0.50 34.34  ? 652  ARG A N   1 
ATOM   2677 C  CA  . ARG A 1 389 ? -9.355  -30.476 -42.663 0.50 34.19  ? 652  ARG A CA  1 
ATOM   2678 C  C   . ARG A 1 389 ? -8.649  -31.848 -42.697 0.50 33.20  ? 652  ARG A C   1 
ATOM   2679 O  O   . ARG A 1 389 ? -8.965  -32.678 -41.811 0.50 31.35  ? 652  ARG A O   1 
ATOM   2680 C  CB  . ARG A 1 389 ? -10.455 -30.311 -43.720 0.50 36.24  ? 652  ARG A CB  1 
ATOM   2681 C  CG  . ARG A 1 389 ? -11.362 -29.114 -43.455 0.50 37.18  ? 652  ARG A CG  1 
ATOM   2682 C  CD  . ARG A 1 389 ? -12.467 -28.918 -44.483 0.50 37.53  ? 652  ARG A CD  1 
ATOM   2683 N  NE  . ARG A 1 389 ? -13.532 -29.900 -44.352 0.50 36.31  ? 652  ARG A NE  1 
ATOM   2684 C  CZ  . ARG A 1 389 ? -14.487 -29.883 -43.420 0.50 35.52  ? 652  ARG A CZ  1 
ATOM   2685 N  NH1 . ARG A 1 389 ? -14.533 -28.920 -42.510 0.50 34.45  ? 652  ARG A NH1 1 
ATOM   2686 N  NH2 . ARG A 1 389 ? -15.393 -30.847 -43.403 0.50 34.08  ? 652  ARG A NH2 1 
ATOM   2687 N  N   . GLU A 1 390 ? -7.736  -32.108 -43.645 0.50 29.66  ? 653  GLU A N   1 
ATOM   2688 C  CA  . GLU A 1 390 ? -6.967  -33.397 -43.705 0.50 29.94  ? 653  GLU A CA  1 
ATOM   2689 C  C   . GLU A 1 390 ? -6.228  -33.594 -42.374 0.50 30.35  ? 653  GLU A C   1 
ATOM   2690 O  O   . GLU A 1 390 ? -6.054  -34.773 -41.946 0.50 28.74  ? 653  GLU A O   1 
ATOM   2691 C  CB  . GLU A 1 390 ? -5.952  -33.408 -44.857 0.50 28.45  ? 653  GLU A CB  1 
ATOM   2692 C  CG  . GLU A 1 390 ? -5.389  -34.783 -45.198 0.50 28.17  ? 653  GLU A CG  1 
ATOM   2693 C  CD  . GLU A 1 390 ? -4.436  -35.415 -44.187 0.50 28.48  ? 653  GLU A CD  1 
ATOM   2694 O  OE1 . GLU A 1 390 ? -3.697  -34.679 -43.505 0.50 27.79  ? 653  GLU A OE1 1 
ATOM   2695 O  OE2 . GLU A 1 390 ? -4.419  -36.661 -44.099 0.50 29.45  ? 653  GLU A OE2 1 
ATOM   2696 N  N   . ARG A 1 391 ? -5.842  -32.480 -41.740 0.50 30.99  ? 654  ARG A N   1 
ATOM   2697 C  CA  . ARG A 1 391 ? -5.002  -32.451 -40.515 0.50 33.04  ? 654  ARG A CA  1 
ATOM   2698 C  C   . ARG A 1 391 ? -5.860  -32.758 -39.278 0.50 30.94  ? 654  ARG A C   1 
ATOM   2699 O  O   . ARG A 1 391 ? -5.441  -33.640 -38.496 0.50 26.60  ? 654  ARG A O   1 
ATOM   2700 C  CB  . ARG A 1 391 ? -4.273  -31.109 -40.395 0.50 36.09  ? 654  ARG A CB  1 
ATOM   2701 C  CG  . ARG A 1 391 ? -3.208  -30.876 -41.462 0.50 39.39  ? 654  ARG A CG  1 
ATOM   2702 C  CD  . ARG A 1 391 ? -1.885  -31.573 -41.195 0.50 44.96  ? 654  ARG A CD  1 
ATOM   2703 N  NE  . ARG A 1 391 ? -0.861  -31.042 -42.081 0.50 47.80  ? 654  ARG A NE  1 
ATOM   2704 C  CZ  . ARG A 1 391 ? -0.564  -31.540 -43.272 0.50 52.94  ? 654  ARG A CZ  1 
ATOM   2705 N  NH1 . ARG A 1 391 ? -1.187  -32.615 -43.724 0.50 53.91  ? 654  ARG A NH1 1 
ATOM   2706 N  NH2 . ARG A 1 391 ? 0.369   -30.964 -44.007 0.50 56.43  ? 654  ARG A NH2 1 
ATOM   2707 N  N   . LEU A 1 392 ? -7.000  -32.067 -39.086 0.50 28.50  ? 655  LEU A N   1 
ATOM   2708 C  CA  . LEU A 1 392 ? -7.943  -32.373 -37.967 0.50 27.31  ? 655  LEU A CA  1 
ATOM   2709 C  C   . LEU A 1 392 ? -8.289  -33.865 -38.021 0.50 29.45  ? 655  LEU A C   1 
ATOM   2710 O  O   . LEU A 1 392 ? -8.621  -34.445 -36.965 0.50 27.89  ? 655  LEU A O   1 
ATOM   2711 C  CB  . LEU A 1 392 ? -9.216  -31.533 -38.092 0.50 26.90  ? 655  LEU A CB  1 
ATOM   2712 C  CG  . LEU A 1 392 ? -9.085  -30.046 -37.789 0.50 25.73  ? 655  LEU A CG  1 
ATOM   2713 C  CD1 . LEU A 1 392 ? -10.367 -29.326 -38.172 0.50 26.70  ? 655  LEU A CD1 1 
ATOM   2714 C  CD2 . LEU A 1 392 ? -8.751  -29.805 -36.321 0.50 24.79  ? 655  LEU A CD2 1 
ATOM   2715 N  N   . SER A 1 393 ? -8.208  -34.450 -39.219 0.50 29.55  ? 656  SER A N   1 
ATOM   2716 C  CA  . SER A 1 393 ? -8.565  -35.859 -39.518 0.50 28.62  ? 656  SER A CA  1 
ATOM   2717 C  C   . SER A 1 393 ? -7.507  -36.817 -38.968 0.50 26.38  ? 656  SER A C   1 
ATOM   2718 O  O   . SER A 1 393 ? -7.833  -37.988 -38.810 0.50 25.32  ? 656  SER A O   1 
ATOM   2719 C  CB  . SER A 1 393 ? -8.758  -36.054 -40.993 0.50 30.61  ? 656  SER A CB  1 
ATOM   2720 O  OG  . SER A 1 393 ? -7.607  -35.637 -41.713 0.50 34.46  ? 656  SER A OG  1 
ATOM   2721 N  N   . ARG A 1 394 ? -6.279  -36.337 -38.723 0.50 25.86  ? 657  ARG A N   1 
ATOM   2722 C  CA  . ARG A 1 394 ? -5.163  -37.149 -38.168 0.50 25.57  ? 657  ARG A CA  1 
ATOM   2723 C  C   . ARG A 1 394 ? -5.295  -37.124 -36.645 0.50 24.77  ? 657  ARG A C   1 
ATOM   2724 O  O   . ARG A 1 394 ? -4.363  -37.565 -35.960 0.50 23.81  ? 657  ARG A O   1 
ATOM   2725 C  CB  . ARG A 1 394 ? -3.795  -36.618 -38.621 0.50 25.46  ? 657  ARG A CB  1 
ATOM   2726 C  CG  . ARG A 1 394 ? -3.600  -36.588 -40.129 0.50 27.70  ? 657  ARG A CG  1 
ATOM   2727 C  CD  . ARG A 1 394 ? -2.277  -35.970 -40.581 0.50 28.02  ? 657  ARG A CD  1 
ATOM   2728 N  NE  . ARG A 1 394 ? -1.958  -36.487 -41.902 0.50 27.36  ? 657  ARG A NE  1 
ATOM   2729 C  CZ  . ARG A 1 394 ? -1.165  -37.524 -42.142 0.50 28.95  ? 657  ARG A CZ  1 
ATOM   2730 N  NH1 . ARG A 1 394 ? -0.514  -38.114 -41.150 0.50 29.61  ? 657  ARG A NH1 1 
ATOM   2731 N  NH2 . ARG A 1 394 ? -1.010  -37.950 -43.384 0.50 28.17  ? 657  ARG A NH2 1 
ATOM   2732 N  N   . MET A 1 395 ? -6.424  -36.628 -36.130 0.50 23.34  ? 658  MET A N   1 
ATOM   2733 C  CA  . MET A 1 395 ? -6.637  -36.547 -34.664 0.50 23.81  ? 658  MET A CA  1 
ATOM   2734 C  C   . MET A 1 395 ? -7.956  -37.228 -34.248 0.50 24.42  ? 658  MET A C   1 
ATOM   2735 O  O   . MET A 1 395 ? -8.955  -37.134 -34.982 0.50 23.60  ? 658  MET A O   1 
ATOM   2736 C  CB  . MET A 1 395 ? -6.604  -35.087 -34.199 0.50 24.58  ? 658  MET A CB  1 
ATOM   2737 C  CG  . MET A 1 395 ? -5.371  -34.330 -34.686 0.50 23.79  ? 658  MET A CG  1 
ATOM   2738 S  SD  . MET A 1 395 ? -5.034  -32.799 -33.763 0.50 23.79  ? 658  MET A SD  1 
ATOM   2739 C  CE  . MET A 1 395 ? -6.431  -31.813 -34.297 0.50 24.97  ? 658  MET A CE  1 
ATOM   2740 N  N   . ALA A 1 396 ? -7.918  -37.909 -33.096 1.00 25.01  ? 659  ALA A N   1 
ATOM   2741 C  CA  . ALA A 1 396 ? -9.080  -38.358 -32.313 1.00 22.02  ? 659  ALA A CA  1 
ATOM   2742 C  C   . ALA A 1 396 ? -8.988  -37.662 -30.978 1.00 23.94  ? 659  ALA A C   1 
ATOM   2743 O  O   . ALA A 1 396 ? -7.993  -37.800 -30.268 1.00 22.97  ? 659  ALA A O   1 
ATOM   2744 C  CB  . ALA A 1 396 ? -9.161  -39.843 -32.179 1.00 23.12  ? 659  ALA A CB  1 
ATOM   2745 N  N   . ILE A 1 397 ? -9.949  -36.769 -30.730 1.00 24.52  ? 660  ILE A N   1 
ATOM   2746 C  CA  . ILE A 1 397 ? -9.932  -35.830 -29.585 1.00 23.16  ? 660  ILE A CA  1 
ATOM   2747 C  C   . ILE A 1 397 ? -11.272 -35.920 -28.837 1.00 26.21  ? 660  ILE A C   1 
ATOM   2748 O  O   . ILE A 1 397 ? -12.296 -35.742 -29.431 1.00 23.53  ? 660  ILE A O   1 
ATOM   2749 C  CB  . ILE A 1 397 ? -9.619  -34.427 -30.080 1.00 23.12  ? 660  ILE A CB  1 
ATOM   2750 C  CG1 . ILE A 1 397 ? -8.271  -34.422 -30.804 1.00 28.28  ? 660  ILE A CG1 1 
ATOM   2751 C  CG2 . ILE A 1 397 ? -9.679  -33.505 -28.886 1.00 26.15  ? 660  ILE A CG2 1 
ATOM   2752 C  CD1 . ILE A 1 397 ? -7.711  -33.068 -31.173 1.00 29.13  ? 660  ILE A CD1 1 
ATOM   2753 N  N   . SER A 1 398 ? -11.183 -36.286 -27.583 1.00 25.68  ? 661  SER A N   1 
ATOM   2754 C  CA  . SER A 1 398 ? -12.285 -36.423 -26.626 1.00 26.32  ? 661  SER A CA  1 
ATOM   2755 C  C   . SER A 1 398 ? -11.962 -35.567 -25.413 1.00 24.95  ? 661  SER A C   1 
ATOM   2756 O  O   . SER A 1 398 ? -11.208 -36.032 -24.557 1.00 28.63  ? 661  SER A O   1 
ATOM   2757 C  CB  . SER A 1 398 ? -12.492 -37.835 -26.251 1.00 27.13  ? 661  SER A CB  1 
ATOM   2758 O  OG  . SER A 1 398 ? -13.670 -37.921 -25.486 1.00 27.64  ? 661  SER A OG  1 
ATOM   2759 N  N   . GLY A 1 399 ? -12.414 -34.303 -25.438 1.00 27.81  ? 662  GLY A N   1 
ATOM   2760 C  CA  . GLY A 1 399 ? -12.046 -33.332 -24.399 1.00 27.72  ? 662  GLY A CA  1 
ATOM   2761 C  C   . GLY A 1 399 ? -10.526 -33.230 -24.291 1.00 28.18  ? 662  GLY A C   1 
ATOM   2762 O  O   . GLY A 1 399 ? -9.872  -32.977 -25.314 1.00 29.44  ? 662  GLY A O   1 
ATOM   2763 N  N   . ASP A 1 400 ? -9.961  -33.416 -23.095 1.00 28.69  ? 663  ASP A N   1 
ATOM   2764 C  CA  . ASP A 1 400 ? -8.500  -33.252 -22.908 1.00 30.65  ? 663  ASP A CA  1 
ATOM   2765 C  C   . ASP A 1 400 ? -7.724  -34.468 -23.461 1.00 28.25  ? 663  ASP A C   1 
ATOM   2766 O  O   . ASP A 1 400 ? -6.505  -34.374 -23.512 1.00 29.66  ? 663  ASP A O   1 
ATOM   2767 C  CB  . ASP A 1 400 ? -8.160  -33.001 -21.448 1.00 32.73  ? 663  ASP A CB  1 
ATOM   2768 C  CG  . ASP A 1 400 ? -8.545  -34.118 -20.497 1.00 36.12  ? 663  ASP A CG  1 
ATOM   2769 O  OD1 . ASP A 1 400 ? -9.006  -35.181 -20.925 1.00 42.12  ? 663  ASP A OD1 1 
ATOM   2770 O  OD2 . ASP A 1 400 ? -8.329  -33.919 -19.314 1.00 45.30  ? 663  ASP A OD2 1 
ATOM   2771 N  N   . ASP A 1 401 ? -8.378  -35.497 -23.996 1.00 27.35  ? 664  ASP A N   1 
ATOM   2772 C  CA  . ASP A 1 401 ? -7.692  -36.744 -24.454 1.00 25.99  ? 664  ASP A CA  1 
ATOM   2773 C  C   . ASP A 1 401 ? -7.471  -36.670 -25.946 1.00 29.78  ? 664  ASP A C   1 
ATOM   2774 O  O   . ASP A 1 401 ? -8.453  -36.402 -26.677 1.00 32.54  ? 664  ASP A O   1 
ATOM   2775 C  CB  . ASP A 1 401 ? -8.514  -37.951 -24.000 1.00 26.94  ? 664  ASP A CB  1 
ATOM   2776 C  CG  . ASP A 1 401 ? -7.722  -39.226 -23.909 1.00 39.23  ? 664  ASP A CG  1 
ATOM   2777 O  OD1 . ASP A 1 401 ? -6.596  -39.117 -24.193 1.00 36.73  ? 664  ASP A OD1 1 
ATOM   2778 O  OD2 . ASP A 1 401 ? -8.266  -40.285 -23.613 1.00 40.22  ? 664  ASP A OD2 1 
ATOM   2779 N  N   . CYS A 1 402 ? -6.246  -36.869 -26.428 1.00 25.40  ? 665  CYS A N   1 
ATOM   2780 C  CA  . CYS A 1 402 ? -6.000  -36.882 -27.879 1.00 25.54  ? 665  CYS A CA  1 
ATOM   2781 C  C   . CYS A 1 402 ? -5.095  -38.021 -28.290 1.00 23.33  ? 665  CYS A C   1 
ATOM   2782 O  O   . CYS A 1 402 ? -4.281  -38.498 -27.509 1.00 27.59  ? 665  CYS A O   1 
ATOM   2783 C  CB  . CYS A 1 402 ? -5.382  -35.576 -28.366 1.00 28.91  ? 665  CYS A CB  1 
ATOM   2784 S  SG  . CYS A 1 402 ? -3.764  -35.204 -27.626 1.00 34.89  ? 665  CYS A SG  1 
ATOM   2785 N  N   . VAL A 1 403 ? -5.247  -38.357 -29.533 1.00 23.65  ? 666  VAL A N   1 
ATOM   2786 C  CA  . VAL A 1 403 ? -4.354  -39.203 -30.374 1.00 24.38  ? 666  VAL A CA  1 
ATOM   2787 C  C   . VAL A 1 403 ? -4.147  -38.405 -31.671 1.00 24.13  ? 666  VAL A C   1 
ATOM   2788 O  O   . VAL A 1 403 ? -5.157  -37.936 -32.265 1.00 24.65  ? 666  VAL A O   1 
ATOM   2789 C  CB  . VAL A 1 403 ? -4.955  -40.579 -30.640 1.00 25.69  ? 666  VAL A CB  1 
ATOM   2790 C  CG1 . VAL A 1 403 ? -4.126  -41.389 -31.610 1.00 28.08  ? 666  VAL A CG1 1 
ATOM   2791 C  CG2 . VAL A 1 403 ? -5.225  -41.335 -29.354 1.00 24.05  ? 666  VAL A CG2 1 
ATOM   2792 N  N   . VAL A 1 404 ? -2.892  -38.209 -32.043 1.00 22.15  ? 667  VAL A N   1 
ATOM   2793 C  CA  . VAL A 1 404 ? -2.493  -37.474 -33.277 1.00 24.61  ? 667  VAL A CA  1 
ATOM   2794 C  C   . VAL A 1 404 ? -1.542  -38.356 -34.082 1.00 24.89  ? 667  VAL A C   1 
ATOM   2795 O  O   . VAL A 1 404 ? -0.563  -38.866 -33.503 1.00 26.39  ? 667  VAL A O   1 
ATOM   2796 C  CB  . VAL A 1 404 ? -1.817  -36.130 -32.916 1.00 25.74  ? 667  VAL A CB  1 
ATOM   2797 C  CG1 . VAL A 1 404 ? -1.487  -35.316 -34.183 1.00 27.14  ? 667  VAL A CG1 1 
ATOM   2798 C  CG2 . VAL A 1 404 ? -2.638  -35.279 -31.970 1.00 26.96  ? 667  VAL A CG2 1 
ATOM   2799 N  N   . LYS A 1 405 ? -1.822  -38.534 -35.373 0.50 26.30  ? 668  LYS A N   1 
ATOM   2800 C  CA  . LYS A 1 405 ? -0.863  -39.106 -36.355 0.50 27.26  ? 668  LYS A CA  1 
ATOM   2801 C  C   . LYS A 1 405 ? -0.383  -37.965 -37.246 0.50 27.19  ? 668  LYS A C   1 
ATOM   2802 O  O   . LYS A 1 405 ? -0.982  -37.699 -38.289 0.50 27.50  ? 668  LYS A O   1 
ATOM   2803 C  CB  . LYS A 1 405 ? -1.448  -40.236 -37.201 0.50 27.49  ? 668  LYS A CB  1 
ATOM   2804 C  CG  . LYS A 1 405 ? -0.430  -40.838 -38.160 0.50 28.69  ? 668  LYS A CG  1 
ATOM   2805 C  CD  . LYS A 1 405 ? -0.679  -42.252 -38.599 0.50 30.83  ? 668  LYS A CD  1 
ATOM   2806 C  CE  . LYS A 1 405 ? 0.433   -42.755 -39.498 0.50 30.77  ? 668  LYS A CE  1 
ATOM   2807 N  NZ  . LYS A 1 405 ? 0.131   -44.091 -40.057 0.50 33.75  ? 668  LYS A NZ  1 
ATOM   2808 N  N   . PRO A 1 406 ? 0.708   -37.261 -36.865 1.00 27.05  ? 669  PRO A N   1 
ATOM   2809 C  CA  . PRO A 1 406 ? 1.207   -36.136 -37.674 1.00 26.96  ? 669  PRO A CA  1 
ATOM   2810 C  C   . PRO A 1 406 ? 1.842   -36.584 -38.976 1.00 26.89  ? 669  PRO A C   1 
ATOM   2811 O  O   . PRO A 1 406 ? 2.100   -37.753 -39.208 1.00 26.42  ? 669  PRO A O   1 
ATOM   2812 C  CB  . PRO A 1 406 ? 2.186   -35.465 -36.717 1.00 26.75  ? 669  PRO A CB  1 
ATOM   2813 C  CG  . PRO A 1 406 ? 2.767   -36.646 -35.916 1.00 27.48  ? 669  PRO A CG  1 
ATOM   2814 C  CD  . PRO A 1 406 ? 1.541   -37.511 -35.668 1.00 27.09  ? 669  PRO A CD  1 
ATOM   2815 N  N   . LEU A 1 407 ? 2.133   -35.611 -39.832 1.00 29.35  ? 670  LEU A N   1 
ATOM   2816 C  CA  . LEU A 1 407 ? 2.752   -35.861 -41.158 1.00 30.72  ? 670  LEU A CA  1 
ATOM   2817 C  C   . LEU A 1 407 ? 4.105   -36.622 -41.046 1.00 26.92  ? 670  LEU A C   1 
ATOM   2818 O  O   . LEU A 1 407 ? 4.370   -37.459 -41.953 1.00 32.05  ? 670  LEU A O   1 
ATOM   2819 C  CB  . LEU A 1 407 ? 2.906   -34.493 -41.834 1.00 32.27  ? 670  LEU A CB  1 
ATOM   2820 C  CG  . LEU A 1 407 ? 3.183   -34.538 -43.330 1.00 38.23  ? 670  LEU A CG  1 
ATOM   2821 C  CD1 . LEU A 1 407 ? 1.951   -34.984 -44.100 1.00 38.51  ? 670  LEU A CD1 1 
ATOM   2822 C  CD2 . LEU A 1 407 ? 3.656   -33.168 -43.803 1.00 42.81  ? 670  LEU A CD2 1 
ATOM   2823 N  N   . ASP A 1 408 ? 4.851   -36.426 -39.964 1.00 28.66  ? 671  ASP A N   1 
ATOM   2824 C  CA  . ASP A 1 408 ? 6.174   -37.068 -39.702 1.00 30.83  ? 671  ASP A CA  1 
ATOM   2825 C  C   . ASP A 1 408 ? 6.520   -36.817 -38.251 1.00 29.85  ? 671  ASP A C   1 
ATOM   2826 O  O   . ASP A 1 408 ? 5.727   -36.204 -37.575 1.00 34.59  ? 671  ASP A O   1 
ATOM   2827 C  CB  . ASP A 1 408 ? 7.242   -36.563 -40.704 1.00 31.56  ? 671  ASP A CB  1 
ATOM   2828 C  CG  . ASP A 1 408 ? 7.310   -35.038 -40.716 1.00 28.06  ? 671  ASP A CG  1 
ATOM   2829 O  OD1 . ASP A 1 408 ? 7.538   -34.448 -39.625 1.00 30.35  ? 671  ASP A OD1 1 
ATOM   2830 O  OD2 . ASP A 1 408 ? 6.975   -34.441 -41.769 1.00 34.51  ? 671  ASP A OD2 1 
ATOM   2831 N  N   . ASP A 1 409 ? 7.672   -37.302 -37.795 1.00 28.98  ? 672  ASP A N   1 
ATOM   2832 C  CA  . ASP A 1 409 ? 8.039   -37.326 -36.375 1.00 28.05  ? 672  ASP A CA  1 
ATOM   2833 C  C   . ASP A 1 409 ? 8.682   -36.012 -35.914 1.00 28.72  ? 672  ASP A C   1 
ATOM   2834 O  O   . ASP A 1 409 ? 9.027   -35.921 -34.752 1.00 28.81  ? 672  ASP A O   1 
ATOM   2835 C  CB  . ASP A 1 409 ? 8.817   -38.615 -36.108 1.00 32.46  ? 672  ASP A CB  1 
ATOM   2836 C  CG  . ASP A 1 409 ? 7.936   -39.849 -36.158 1.00 35.24  ? 672  ASP A CG  1 
ATOM   2837 O  OD1 . ASP A 1 409 ? 6.850   -39.805 -35.541 1.00 33.33  ? 672  ASP A OD1 1 
ATOM   2838 O  OD2 . ASP A 1 409 ? 8.336   -40.828 -36.800 1.00 35.06  ? 672  ASP A OD2 1 
ATOM   2839 N  N   . ARG A 1 410 ? 8.777   -34.974 -36.736 1.00 29.26  ? 673  ARG A N   1 
ATOM   2840 C  CA  . ARG A 1 410 ? 9.247   -33.664 -36.215 1.00 31.66  ? 673  ARG A CA  1 
ATOM   2841 C  C   . ARG A 1 410 ? 8.322   -33.195 -35.099 1.00 30.39  ? 673  ARG A C   1 
ATOM   2842 O  O   . ARG A 1 410 ? 8.759   -32.494 -34.226 1.00 28.35  ? 673  ARG A O   1 
ATOM   2843 C  CB  . ARG A 1 410 ? 9.307   -32.580 -37.296 1.00 32.52  ? 673  ARG A CB  1 
ATOM   2844 C  CG  . ARG A 1 410 ? 10.328  -32.818 -38.402 1.00 34.15  ? 673  ARG A CG  1 
ATOM   2845 C  CD  . ARG A 1 410 ? 10.178  -31.772 -39.501 1.00 33.05  ? 673  ARG A CD  1 
ATOM   2846 N  NE  . ARG A 1 410 ? 9.025   -32.059 -40.336 1.00 32.31  ? 673  ARG A NE  1 
ATOM   2847 C  CZ  . ARG A 1 410 ? 8.483   -31.271 -41.252 1.00 32.74  ? 673  ARG A CZ  1 
ATOM   2848 N  NH1 . ARG A 1 410 ? 8.977   -30.064 -41.499 1.00 33.29  ? 673  ARG A NH1 1 
ATOM   2849 N  NH2 . ARG A 1 410 ? 7.436   -31.724 -41.926 1.00 30.34  ? 673  ARG A NH2 1 
ATOM   2850 N  N   . PHE A 1 411 ? 7.024   -33.552 -35.185 1.00 33.42  ? 674  PHE A N   1 
ATOM   2851 C  CA  . PHE A 1 411 ? 5.988   -33.357 -34.136 1.00 27.58  ? 674  PHE A CA  1 
ATOM   2852 C  C   . PHE A 1 411 ? 6.509   -33.724 -32.769 1.00 25.57  ? 674  PHE A C   1 
ATOM   2853 O  O   . PHE A 1 411 ? 6.232   -32.960 -31.849 1.00 28.60  ? 674  PHE A O   1 
ATOM   2854 C  CB  . PHE A 1 411 ? 4.726   -34.164 -34.499 1.00 28.40  ? 674  PHE A CB  1 
ATOM   2855 C  CG  . PHE A 1 411 ? 3.564   -33.946 -33.561 1.00 28.42  ? 674  PHE A CG  1 
ATOM   2856 C  CD1 . PHE A 1 411 ? 3.387   -34.784 -32.470 1.00 26.74  ? 674  PHE A CD1 1 
ATOM   2857 C  CD2 . PHE A 1 411 ? 2.558   -33.049 -33.864 1.00 28.33  ? 674  PHE A CD2 1 
ATOM   2858 C  CE1 . PHE A 1 411 ? 2.280   -34.628 -31.636 1.00 28.45  ? 674  PHE A CE1 1 
ATOM   2859 C  CE2 . PHE A 1 411 ? 1.464   -32.867 -33.012 1.00 27.81  ? 674  PHE A CE2 1 
ATOM   2860 C  CZ  . PHE A 1 411 ? 1.317   -33.667 -31.904 1.00 27.79  ? 674  PHE A CZ  1 
ATOM   2861 N  N   . ALA A 1 412 ? 7.265   -34.830 -32.595 1.00 27.50  ? 675  ALA A N   1 
ATOM   2862 C  CA  . ALA A 1 412 ? 7.721   -35.304 -31.268 1.00 29.11  ? 675  ALA A CA  1 
ATOM   2863 C  C   . ALA A 1 412 ? 8.464   -34.229 -30.444 1.00 32.35  ? 675  ALA A C   1 
ATOM   2864 O  O   . ALA A 1 412 ? 8.289   -34.167 -29.207 1.00 28.85  ? 675  ALA A O   1 
ATOM   2865 C  CB  . ALA A 1 412 ? 8.579   -36.548 -31.455 1.00 28.72  ? 675  ALA A CB  1 
ATOM   2866 N  N   . SER A 1 413 ? 9.275   -33.378 -31.085 1.00 34.66  ? 676  SER A N   1 
ATOM   2867 C  CA  . SER A 1 413 ? 10.088  -32.343 -30.395 1.00 31.86  ? 676  SER A CA  1 
ATOM   2868 C  C   . SER A 1 413 ? 9.573   -30.938 -30.730 1.00 35.85  ? 676  SER A C   1 
ATOM   2869 O  O   . SER A 1 413 ? 10.260  -29.946 -30.411 1.00 34.16  ? 676  SER A O   1 
ATOM   2870 C  CB  . SER A 1 413 ? 11.575  -32.500 -30.793 1.00 35.09  ? 676  SER A CB  1 
ATOM   2871 O  OG  . SER A 1 413 ? 11.669  -32.532 -32.216 1.00 37.65  ? 676  SER A OG  1 
ATOM   2872 N  N   . ALA A 1 414 ? 8.382   -30.816 -31.311 1.00 35.68  ? 677  ALA A N   1 
ATOM   2873 C  CA  . ALA A 1 414 ? 7.751   -29.504 -31.572 1.00 34.86  ? 677  ALA A CA  1 
ATOM   2874 C  C   . ALA A 1 414 ? 6.984   -29.120 -30.317 1.00 35.43  ? 677  ALA A C   1 
ATOM   2875 O  O   . ALA A 1 414 ? 5.767   -29.458 -30.222 1.00 37.19  ? 677  ALA A O   1 
ATOM   2876 C  CB  . ALA A 1 414 ? 6.889   -29.575 -32.801 1.00 35.08  ? 677  ALA A CB  1 
ATOM   2877 N  N   . LEU A 1 415 ? 7.654   -28.484 -29.362 1.00 29.98  ? 678  LEU A N   1 
ATOM   2878 C  CA  . LEU A 1 415 ? 7.140   -28.307 -27.994 1.00 30.73  ? 678  LEU A CA  1 
ATOM   2879 C  C   . LEU A 1 415 ? 7.014   -26.844 -27.567 1.00 31.23  ? 678  LEU A C   1 
ATOM   2880 O  O   . LEU A 1 415 ? 6.433   -26.648 -26.474 1.00 35.44  ? 678  LEU A O   1 
ATOM   2881 C  CB  . LEU A 1 415 ? 7.995   -29.064 -26.998 1.00 32.77  ? 678  LEU A CB  1 
ATOM   2882 C  CG  . LEU A 1 415 ? 8.036   -30.579 -27.208 1.00 35.18  ? 678  LEU A CG  1 
ATOM   2883 C  CD1 . LEU A 1 415 ? 9.200   -31.179 -26.445 1.00 35.43  ? 678  LEU A CD1 1 
ATOM   2884 C  CD2 . LEU A 1 415 ? 6.734   -31.211 -26.760 1.00 34.44  ? 678  LEU A CD2 1 
ATOM   2885 N  N   . THR A 1 416 ? 7.437   -25.868 -28.349 1.00 34.16  ? 679  THR A N   1 
ATOM   2886 C  CA  . THR A 1 416 ? 7.488   -24.463 -27.835 1.00 34.98  ? 679  THR A CA  1 
ATOM   2887 C  C   . THR A 1 416 ? 6.055   -23.884 -27.726 1.00 32.97  ? 679  THR A C   1 
ATOM   2888 O  O   . THR A 1 416 ? 5.720   -23.333 -26.644 1.00 32.34  ? 679  THR A O   1 
ATOM   2889 C  CB  . THR A 1 416 ? 8.391   -23.553 -28.688 1.00 34.25  ? 679  THR A CB  1 
ATOM   2890 O  OG1 . THR A 1 416 ? 7.887   -23.426 -30.010 1.00 35.64  ? 679  THR A OG1 1 
ATOM   2891 C  CG2 . THR A 1 416 ? 9.823   -24.045 -28.840 1.00 38.69  ? 679  THR A CG2 1 
ATOM   2892 N  N   . ALA A 1 417 ? 5.225   -24.021 -28.769 1.00 35.80  ? 680  ALA A N   1 
ATOM   2893 C  CA  . ALA A 1 417 ? 3.807   -23.568 -28.742 1.00 36.30  ? 680  ALA A CA  1 
ATOM   2894 C  C   . ALA A 1 417 ? 3.064   -24.336 -27.631 1.00 36.61  ? 680  ALA A C   1 
ATOM   2895 O  O   . ALA A 1 417 ? 2.458   -23.687 -26.747 1.00 37.67  ? 680  ALA A O   1 
ATOM   2896 C  CB  . ALA A 1 417 ? 3.198   -23.697 -30.119 1.00 38.07  ? 680  ALA A CB  1 
ATOM   2897 N  N   . LEU A 1 418 ? 3.213   -25.668 -27.570 1.00 36.32  ? 681  LEU A N   1 
ATOM   2898 C  CA  . LEU A 1 418 ? 2.455   -26.481 -26.599 1.00 32.09  ? 681  LEU A CA  1 
ATOM   2899 C  C   . LEU A 1 418 ? 2.733   -26.001 -25.175 1.00 33.24  ? 681  LEU A C   1 
ATOM   2900 O  O   . LEU A 1 418 ? 1.780   -25.819 -24.413 1.00 29.94  ? 681  LEU A O   1 
ATOM   2901 C  CB  . LEU A 1 418 ? 2.752   -27.978 -26.811 1.00 31.88  ? 681  LEU A CB  1 
ATOM   2902 C  CG  . LEU A 1 418 ? 1.849   -28.920 -26.047 1.00 33.38  ? 681  LEU A CG  1 
ATOM   2903 C  CD1 . LEU A 1 418 ? 0.470   -28.992 -26.715 1.00 35.43  ? 681  LEU A CD1 1 
ATOM   2904 C  CD2 . LEU A 1 418 ? 2.474   -30.299 -25.926 1.00 34.44  ? 681  LEU A CD2 1 
ATOM   2905 N  N   . ASN A 1 419 ? 4.017   -25.842 -24.799 1.00 38.74  ? 682  ASN A N   1 
ATOM   2906 C  CA  . ASN A 1 419 ? 4.420   -25.457 -23.426 1.00 36.75  ? 682  ASN A CA  1 
ATOM   2907 C  C   . ASN A 1 419 ? 3.988   -24.005 -23.210 1.00 32.33  ? 682  ASN A C   1 
ATOM   2908 O  O   . ASN A 1 419 ? 3.471   -23.726 -22.158 1.00 35.89  ? 682  ASN A O   1 
ATOM   2909 C  CB  . ASN A 1 419 ? 5.926   -25.703 -23.190 1.00 41.02  ? 682  ASN A CB  1 
ATOM   2910 C  CG  . ASN A 1 419 ? 6.279   -27.171 -22.961 1.00 39.67  ? 682  ASN A CG  1 
ATOM   2911 O  OD1 . ASN A 1 419 ? 5.521   -27.950 -22.395 1.00 39.84  ? 682  ASN A OD1 1 
ATOM   2912 N  ND2 . ASN A 1 419 ? 7.478   -27.557 -23.337 1.00 40.88  ? 682  ASN A ND2 1 
ATOM   2913 N  N   . ASP A 1 420 ? 4.114   -23.139 -24.216 1.00 34.07  ? 683  ASP A N   1 
ATOM   2914 C  CA  . ASP A 1 420 ? 3.787   -21.696 -24.043 1.00 39.71  ? 683  ASP A CA  1 
ATOM   2915 C  C   . ASP A 1 420 ? 2.255   -21.500 -23.927 1.00 43.37  ? 683  ASP A C   1 
ATOM   2916 O  O   . ASP A 1 420 ? 1.866   -20.562 -23.249 1.00 41.41  ? 683  ASP A O   1 
ATOM   2917 C  CB  . ASP A 1 420 ? 4.358   -20.824 -25.162 1.00 41.51  ? 683  ASP A CB  1 
ATOM   2918 C  CG  . ASP A 1 420 ? 4.282   -19.340 -24.813 1.00 41.67  ? 683  ASP A CG  1 
ATOM   2919 O  OD1 . ASP A 1 420 ? 4.640   -18.998 -23.654 1.00 41.59  ? 683  ASP A OD1 1 
ATOM   2920 O  OD2 . ASP A 1 420 ? 3.796   -18.570 -25.665 1.00 42.53  ? 683  ASP A OD2 1 
ATOM   2921 N  N   . MET A 1 421 ? 1.417   -22.372 -24.508 1.00 41.66  ? 684  MET A N   1 
ATOM   2922 C  CA  . MET A 1 421 ? -0.057  -22.305 -24.324 1.00 36.39  ? 684  MET A CA  1 
ATOM   2923 C  C   . MET A 1 421 ? -0.414  -22.794 -22.925 1.00 36.48  ? 684  MET A C   1 
ATOM   2924 O  O   . MET A 1 421 ? -1.565  -22.643 -22.535 1.00 38.64  ? 684  MET A O   1 
ATOM   2925 C  CB  . MET A 1 421 ? -0.815  -23.112 -25.382 1.00 34.89  ? 684  MET A CB  1 
ATOM   2926 C  CG  . MET A 1 421 ? -0.593  -22.549 -26.760 1.00 36.29  ? 684  MET A CG  1 
ATOM   2927 S  SD  . MET A 1 421 ? -1.498  -23.397 -28.100 1.00 40.54  ? 684  MET A SD  1 
ATOM   2928 C  CE  . MET A 1 421 ? -0.687  -24.989 -28.220 1.00 41.08  ? 684  MET A CE  1 
ATOM   2929 N  N   . GLY A 1 422 ? 0.532   -23.361 -22.180 1.00 39.43  ? 685  GLY A N   1 
ATOM   2930 C  CA  . GLY A 1 422 ? 0.317   -23.894 -20.824 1.00 30.88  ? 685  GLY A CA  1 
ATOM   2931 C  C   . GLY A 1 422 ? -0.077  -25.355 -20.811 1.00 31.39  ? 685  GLY A C   1 
ATOM   2932 O  O   . GLY A 1 422 ? -0.264  -25.917 -19.698 1.00 37.71  ? 685  GLY A O   1 
ATOM   2933 N  N   . LYS A 1 423 ? -0.167  -26.011 -21.960 1.00 32.06  ? 686  LYS A N   1 
ATOM   2934 C  CA  . LYS A 1 423 ? -0.617  -27.449 -22.045 1.00 37.79  ? 686  LYS A CA  1 
ATOM   2935 C  C   . LYS A 1 423 ? 0.577   -28.410 -21.853 1.00 36.41  ? 686  LYS A C   1 
ATOM   2936 O  O   . LYS A 1 423 ? 0.911   -29.220 -22.770 1.00 37.07  ? 686  LYS A O   1 
ATOM   2937 C  CB  . LYS A 1 423 ? -1.384  -27.631 -23.355 1.00 33.85  ? 686  LYS A CB  1 
ATOM   2938 C  CG  . LYS A 1 423 ? -2.529  -26.637 -23.515 1.00 33.21  ? 686  LYS A CG  1 
ATOM   2939 C  CD  . LYS A 1 423 ? -3.500  -26.681 -22.344 1.00 36.55  ? 686  LYS A CD  1 
ATOM   2940 C  CE  . LYS A 1 423 ? -4.658  -25.725 -22.484 1.00 39.56  ? 686  LYS A CE  1 
ATOM   2941 N  NZ  . LYS A 1 423 ? -4.195  -24.306 -22.449 1.00 43.80  ? 686  LYS A NZ  1 
ATOM   2942 N  N   . VAL A 1 424 ? 1.249   -28.315 -20.703 0.50 38.67  ? 687  VAL A N   1 
ATOM   2943 C  CA  . VAL A 1 424 ? 2.498   -29.074 -20.390 0.50 38.23  ? 687  VAL A CA  1 
ATOM   2944 C  C   . VAL A 1 424 ? 2.147   -30.559 -20.250 0.50 36.33  ? 687  VAL A C   1 
ATOM   2945 O  O   . VAL A 1 424 ? 1.133   -30.873 -19.582 0.50 38.91  ? 687  VAL A O   1 
ATOM   2946 C  CB  . VAL A 1 424 ? 3.182   -28.516 -19.124 0.50 40.67  ? 687  VAL A CB  1 
ATOM   2947 C  CG1 . VAL A 1 424 ? 4.381   -29.354 -18.694 0.50 41.14  ? 687  VAL A CG1 1 
ATOM   2948 C  CG2 . VAL A 1 424 ? 3.584   -27.060 -19.311 0.50 40.84  ? 687  VAL A CG2 1 
ATOM   2949 N  N   . ARG A 1 425 ? 2.952   -31.431 -20.863 0.50 35.13  ? 688  ARG A N   1 
ATOM   2950 C  CA  . ARG A 1 425 ? 2.732   -32.902 -20.906 0.50 36.56  ? 688  ARG A CA  1 
ATOM   2951 C  C   . ARG A 1 425 ? 3.011   -33.521 -19.534 0.50 38.54  ? 688  ARG A C   1 
ATOM   2952 O  O   . ARG A 1 425 ? 3.983   -33.097 -18.874 0.50 40.36  ? 688  ARG A O   1 
ATOM   2953 C  CB  . ARG A 1 425 ? 3.614   -33.534 -21.982 0.50 36.53  ? 688  ARG A CB  1 
ATOM   2954 C  CG  . ARG A 1 425 ? 3.330   -33.020 -23.384 0.50 35.73  ? 688  ARG A CG  1 
ATOM   2955 C  CD  . ARG A 1 425 ? 4.455   -33.380 -24.326 0.50 35.21  ? 688  ARG A CD  1 
ATOM   2956 N  NE  . ARG A 1 425 ? 5.727   -32.914 -23.803 0.50 34.98  ? 688  ARG A NE  1 
ATOM   2957 C  CZ  . ARG A 1 425 ? 6.910   -33.460 -24.067 0.50 34.82  ? 688  ARG A CZ  1 
ATOM   2958 N  NH1 . ARG A 1 425 ? 7.008   -34.512 -24.865 0.50 32.43  ? 688  ARG A NH1 1 
ATOM   2959 N  NH2 . ARG A 1 425 ? 7.995   -32.943 -23.520 0.50 36.00  ? 688  ARG A NH2 1 
ATOM   2960 N  N   . LYS A 1 426 ? 2.182   -34.491 -19.139 0.50 38.18  ? 689  LYS A N   1 
ATOM   2961 C  CA  . LYS A 1 426 ? 2.287   -35.238 -17.862 0.50 40.78  ? 689  LYS A CA  1 
ATOM   2962 C  C   . LYS A 1 426 ? 3.270   -36.413 -18.013 0.50 41.07  ? 689  LYS A C   1 
ATOM   2963 O  O   . LYS A 1 426 ? 3.123   -37.200 -18.967 0.50 41.10  ? 689  LYS A O   1 
ATOM   2964 C  CB  . LYS A 1 426 ? 0.905   -35.739 -17.432 0.50 42.92  ? 689  LYS A CB  1 
ATOM   2965 C  CG  . LYS A 1 426 ? 0.931   -36.860 -16.401 0.50 47.52  ? 689  LYS A CG  1 
ATOM   2966 C  CD  . LYS A 1 426 ? -0.385  -37.075 -15.681 0.50 50.81  ? 689  LYS A CD  1 
ATOM   2967 C  CE  . LYS A 1 426 ? -1.522  -37.429 -16.614 0.50 54.00  ? 689  LYS A CE  1 
ATOM   2968 N  NZ  . LYS A 1 426 ? -2.751  -37.790 -15.866 0.50 55.46  ? 689  LYS A NZ  1 
ATOM   2969 N  N   . ASP A 1 427 ? 4.231   -36.527 -17.090 0.50 43.01  ? 690  ASP A N   1 
ATOM   2970 C  CA  . ASP A 1 427 ? 5.094   -37.730 -16.928 0.50 43.98  ? 690  ASP A CA  1 
ATOM   2971 C  C   . ASP A 1 427 ? 6.295   -37.650 -17.885 0.50 42.98  ? 690  ASP A C   1 
ATOM   2972 O  O   . ASP A 1 427 ? 6.753   -38.714 -18.346 0.50 41.47  ? 690  ASP A O   1 
ATOM   2973 C  CB  . ASP A 1 427 ? 4.277   -39.011 -17.145 0.50 45.13  ? 690  ASP A CB  1 
ATOM   2974 C  CG  . ASP A 1 427 ? 3.152   -39.189 -16.134 0.50 48.97  ? 690  ASP A CG  1 
ATOM   2975 O  OD1 . ASP A 1 427 ? 3.086   -38.369 -15.189 0.50 51.11  ? 690  ASP A OD1 1 
ATOM   2976 O  OD2 . ASP A 1 427 ? 2.343   -40.140 -16.296 0.50 46.92  ? 690  ASP A OD2 1 
ATOM   2977 N  N   . ILE A 1 428 ? 6.809   -36.444 -18.156 0.50 39.11  ? 691  ILE A N   1 
ATOM   2978 C  CA  . ILE A 1 428 ? 7.964   -36.258 -19.084 0.50 40.35  ? 691  ILE A CA  1 
ATOM   2979 C  C   . ILE A 1 428 ? 8.554   -34.857 -18.890 0.50 41.31  ? 691  ILE A C   1 
ATOM   2980 O  O   . ILE A 1 428 ? 7.783   -33.885 -18.855 0.50 39.72  ? 691  ILE A O   1 
ATOM   2981 C  CB  . ILE A 1 428 ? 7.532   -36.524 -20.543 0.50 39.07  ? 691  ILE A CB  1 
ATOM   2982 C  CG1 . ILE A 1 428 ? 8.738   -36.686 -21.467 0.50 39.93  ? 691  ILE A CG1 1 
ATOM   2983 C  CG2 . ILE A 1 428 ? 6.588   -35.444 -21.049 0.50 39.87  ? 691  ILE A CG2 1 
ATOM   2984 C  CD1 . ILE A 1 428 ? 8.401   -37.265 -22.814 0.50 38.90  ? 691  ILE A CD1 1 
ATOM   2985 N  N   . GLN A 1 429 ? 9.880   -34.762 -18.753 0.50 42.49  ? 692  GLN A N   1 
ATOM   2986 C  CA  . GLN A 1 429 ? 10.599  -33.467 -18.611 0.50 42.76  ? 692  GLN A CA  1 
ATOM   2987 C  C   . GLN A 1 429 ? 10.020  -32.481 -19.626 0.50 41.93  ? 692  GLN A C   1 
ATOM   2988 O  O   . GLN A 1 429 ? 9.791   -32.879 -20.782 0.50 41.81  ? 692  GLN A O   1 
ATOM   2989 C  CB  . GLN A 1 429 ? 12.108  -33.653 -18.810 0.50 46.70  ? 692  GLN A CB  1 
ATOM   2990 C  CG  . GLN A 1 429 ? 12.702  -34.742 -17.925 0.50 49.49  ? 692  GLN A CG  1 
ATOM   2991 C  CD  . GLN A 1 429 ? 14.032  -35.272 -18.411 0.50 52.16  ? 692  GLN A CD  1 
ATOM   2992 O  OE1 . GLN A 1 429 ? 14.752  -34.599 -19.146 0.50 56.40  ? 692  GLN A OE1 1 
ATOM   2993 N  NE2 . GLN A 1 429 ? 14.370  -36.489 -18.008 0.50 54.46  ? 692  GLN A NE2 1 
ATOM   2994 N  N   . GLN A 1 430 ? 9.813   -31.234 -19.210 0.50 45.07  ? 693  GLN A N   1 
ATOM   2995 C  CA  . GLN A 1 430 ? 9.174   -30.186 -20.043 0.50 45.18  ? 693  GLN A CA  1 
ATOM   2996 C  C   . GLN A 1 430 ? 9.632   -30.316 -21.497 0.50 42.35  ? 693  GLN A C   1 
ATOM   2997 O  O   . GLN A 1 430 ? 8.773   -30.152 -22.381 0.50 41.11  ? 693  GLN A O   1 
ATOM   2998 C  CB  . GLN A 1 430 ? 9.500   -28.779 -19.542 0.50 49.69  ? 693  GLN A CB  1 
ATOM   2999 C  CG  . GLN A 1 430 ? 8.787   -27.704 -20.350 0.50 52.08  ? 693  GLN A CG  1 
ATOM   3000 C  CD  . GLN A 1 430 ? 9.197   -26.296 -19.997 0.50 53.33  ? 693  GLN A CD  1 
ATOM   3001 O  OE1 . GLN A 1 430 ? 10.257  -26.058 -19.420 0.50 53.62  ? 693  GLN A OE1 1 
ATOM   3002 N  NE2 . GLN A 1 430 ? 8.349   -25.345 -20.355 0.50 52.59  ? 693  GLN A NE2 1 
ATOM   3003 N  N   . TRP A 1 431 ? 10.925  -30.568 -21.738 0.50 39.49  ? 694  TRP A N   1 
ATOM   3004 C  CA  . TRP A 1 431 ? 11.544  -30.453 -23.087 0.50 38.69  ? 694  TRP A CA  1 
ATOM   3005 C  C   . TRP A 1 431 ? 12.053  -31.808 -23.589 0.50 37.40  ? 694  TRP A C   1 
ATOM   3006 O  O   . TRP A 1 431 ? 12.725  -31.833 -24.632 0.50 36.37  ? 694  TRP A O   1 
ATOM   3007 C  CB  . TRP A 1 431 ? 12.638  -29.380 -23.073 0.50 40.89  ? 694  TRP A CB  1 
ATOM   3008 C  CG  . TRP A 1 431 ? 12.118  -28.075 -22.556 0.50 43.08  ? 694  TRP A CG  1 
ATOM   3009 C  CD1 . TRP A 1 431 ? 12.283  -27.574 -21.298 0.50 42.25  ? 694  TRP A CD1 1 
ATOM   3010 C  CD2 . TRP A 1 431 ? 11.274  -27.137 -23.256 0.50 41.30  ? 694  TRP A CD2 1 
ATOM   3011 N  NE1 . TRP A 1 431 ? 11.635  -26.374 -21.179 0.50 43.44  ? 694  TRP A NE1 1 
ATOM   3012 C  CE2 . TRP A 1 431 ? 11.008  -26.078 -22.362 0.50 41.89  ? 694  TRP A CE2 1 
ATOM   3013 C  CE3 . TRP A 1 431 ? 10.751  -27.066 -24.552 0.50 42.26  ? 694  TRP A CE3 1 
ATOM   3014 C  CZ2 . TRP A 1 431 ? 10.228  -24.977 -22.717 0.50 41.65  ? 694  TRP A CZ2 1 
ATOM   3015 C  CZ3 . TRP A 1 431 ? 9.983   -25.976 -24.902 0.50 41.53  ? 694  TRP A CZ3 1 
ATOM   3016 C  CH2 . TRP A 1 431 ? 9.723   -24.951 -23.995 0.50 39.69  ? 694  TRP A CH2 1 
ATOM   3017 N  N   . GLU A 1 432 ? 11.691  -32.899 -22.917 0.50 37.15  ? 695  GLU A N   1 
ATOM   3018 C  CA  . GLU A 1 432 ? 11.954  -34.276 -23.415 0.50 36.46  ? 695  GLU A CA  1 
ATOM   3019 C  C   . GLU A 1 432 ? 10.945  -34.590 -24.524 0.50 38.11  ? 695  GLU A C   1 
ATOM   3020 O  O   . GLU A 1 432 ? 9.734   -34.481 -24.323 0.50 34.83  ? 695  GLU A O   1 
ATOM   3021 C  CB  . GLU A 1 432 ? 11.912  -35.248 -22.237 0.50 37.94  ? 695  GLU A CB  1 
ATOM   3022 C  CG  . GLU A 1 432 ? 12.068  -36.698 -22.642 0.50 40.13  ? 695  GLU A CG  1 
ATOM   3023 C  CD  . GLU A 1 432 ? 12.225  -37.664 -21.484 0.50 39.79  ? 695  GLU A CD  1 
ATOM   3024 O  OE1 . GLU A 1 432 ? 12.490  -38.841 -21.752 0.50 41.67  ? 695  GLU A OE1 1 
ATOM   3025 O  OE2 . GLU A 1 432 ? 12.088  -37.230 -20.317 0.50 42.78  ? 695  GLU A OE2 1 
ATOM   3026 N  N   . PRO A 1 433 ? 11.422  -34.946 -25.739 0.50 33.79  ? 696  PRO A N   1 
ATOM   3027 C  CA  . PRO A 1 433 ? 10.549  -35.208 -26.884 0.50 33.49  ? 696  PRO A CA  1 
ATOM   3028 C  C   . PRO A 1 433 ? 9.610   -36.417 -26.723 0.50 31.81  ? 696  PRO A C   1 
ATOM   3029 O  O   . PRO A 1 433 ? 10.024  -37.458 -26.234 0.50 27.11  ? 696  PRO A O   1 
ATOM   3030 C  CB  . PRO A 1 433 ? 11.520  -35.463 -28.054 0.50 35.18  ? 696  PRO A CB  1 
ATOM   3031 C  CG  . PRO A 1 433 ? 12.866  -34.904 -27.580 0.50 35.78  ? 696  PRO A CG  1 
ATOM   3032 C  CD  . PRO A 1 433 ? 12.851  -35.080 -26.076 0.50 34.83  ? 696  PRO A CD  1 
ATOM   3033 N  N   . SER A 1 434 ? 8.370   -36.271 -27.199 1.00 31.37  ? 697  SER A N   1 
ATOM   3034 C  CA  . SER A 1 434 ? 7.271   -37.218 -26.908 1.00 31.61  ? 697  SER A CA  1 
ATOM   3035 C  C   . SER A 1 434 ? 7.658   -38.622 -27.360 1.00 31.32  ? 697  SER A C   1 
ATOM   3036 O  O   . SER A 1 434 ? 8.237   -38.756 -28.406 1.00 34.61  ? 697  SER A O   1 
ATOM   3037 C  CB  . SER A 1 434 ? 6.014   -36.750 -27.612 1.00 30.60  ? 697  SER A CB  1 
ATOM   3038 O  OG  . SER A 1 434 ? 5.491   -35.584 -26.995 1.00 28.47  ? 697  SER A OG  1 
ATOM   3039 N  N   . ARG A 1 435 ? 7.251   -39.642 -26.597 0.50 33.03  ? 698  ARG A N   1 
ATOM   3040 C  CA  . ARG A 1 435 ? 7.299   -41.080 -26.982 0.50 35.79  ? 698  ARG A CA  1 
ATOM   3041 C  C   . ARG A 1 435 ? 6.167   -41.381 -27.981 0.50 33.02  ? 698  ARG A C   1 
ATOM   3042 O  O   . ARG A 1 435 ? 5.007   -41.078 -27.668 0.50 34.53  ? 698  ARG A O   1 
ATOM   3043 C  CB  . ARG A 1 435 ? 7.157   -41.945 -25.719 0.50 37.72  ? 698  ARG A CB  1 
ATOM   3044 C  CG  . ARG A 1 435 ? 8.269   -41.749 -24.694 0.50 40.45  ? 698  ARG A CG  1 
ATOM   3045 C  CD  . ARG A 1 435 ? 8.070   -42.527 -23.405 0.50 41.80  ? 698  ARG A CD  1 
ATOM   3046 N  NE  . ARG A 1 435 ? 7.010   -41.946 -22.598 0.50 46.56  ? 698  ARG A NE  1 
ATOM   3047 C  CZ  . ARG A 1 435 ? 7.195   -41.258 -21.481 0.50 45.47  ? 698  ARG A CZ  1 
ATOM   3048 N  NH1 . ARG A 1 435 ? 8.417   -41.074 -21.011 0.50 47.01  ? 698  ARG A NH1 1 
ATOM   3049 N  NH2 . ARG A 1 435 ? 6.154   -40.764 -20.836 0.50 45.66  ? 698  ARG A NH2 1 
ATOM   3050 N  N   . GLY A 1 436 ? 6.483   -41.997 -29.117 0.50 31.49  ? 699  GLY A N   1 
ATOM   3051 C  CA  . GLY A 1 436 ? 5.515   -42.329 -30.183 0.50 31.83  ? 699  GLY A CA  1 
ATOM   3052 C  C   . GLY A 1 436 ? 5.057   -43.780 -30.122 0.50 30.36  ? 699  GLY A C   1 
ATOM   3053 O  O   . GLY A 1 436 ? 5.903   -44.635 -29.844 0.50 31.44  ? 699  GLY A O   1 
ATOM   3054 N  N   . TRP A 1 437 ? 3.790   -44.071 -30.452 1.00 30.61  ? 700  TRP A N   1 
ATOM   3055 C  CA  . TRP A 1 437 ? 3.327   -45.468 -30.495 1.00 27.87  ? 700  TRP A CA  1 
ATOM   3056 C  C   . TRP A 1 437 ? 3.382   -45.927 -31.941 1.00 31.48  ? 700  TRP A C   1 
ATOM   3057 O  O   . TRP A 1 437 ? 2.930   -45.190 -32.818 1.00 34.47  ? 700  TRP A O   1 
ATOM   3058 C  CB  . TRP A 1 437 ? 1.944   -45.601 -29.852 1.00 26.66  ? 700  TRP A CB  1 
ATOM   3059 C  CG  . TRP A 1 437 ? 1.839   -45.157 -28.427 1.00 26.60  ? 700  TRP A CG  1 
ATOM   3060 C  CD1 . TRP A 1 437 ? 1.598   -43.910 -27.938 1.00 32.54  ? 700  TRP A CD1 1 
ATOM   3061 C  CD2 . TRP A 1 437 ? 1.945   -46.021 -27.284 1.00 26.39  ? 700  TRP A CD2 1 
ATOM   3062 N  NE1 . TRP A 1 437 ? 1.515   -43.956 -26.570 1.00 32.35  ? 700  TRP A NE1 1 
ATOM   3063 C  CE2 . TRP A 1 437 ? 1.726   -45.242 -26.149 1.00 26.11  ? 700  TRP A CE2 1 
ATOM   3064 C  CE3 . TRP A 1 437 ? 2.193   -47.368 -27.158 1.00 27.21  ? 700  TRP A CE3 1 
ATOM   3065 C  CZ2 . TRP A 1 437 ? 1.759   -45.767 -24.863 1.00 29.33  ? 700  TRP A CZ2 1 
ATOM   3066 C  CZ3 . TRP A 1 437 ? 2.220   -47.899 -25.899 1.00 31.30  ? 700  TRP A CZ3 1 
ATOM   3067 C  CH2 . TRP A 1 437 ? 1.952   -47.123 -24.775 1.00 27.22  ? 700  TRP A CH2 1 
ATOM   3068 N  N   . ASN A 1 438 ? 4.004   -47.071 -32.197 1.00 31.82  ? 701  ASN A N   1 
ATOM   3069 C  CA  . ASN A 1 438 ? 4.165   -47.597 -33.565 1.00 34.47  ? 701  ASN A CA  1 
ATOM   3070 C  C   . ASN A 1 438 ? 2.985   -48.461 -33.984 1.00 34.01  ? 701  ASN A C   1 
ATOM   3071 O  O   . ASN A 1 438 ? 2.939   -48.778 -35.128 1.00 35.84  ? 701  ASN A O   1 
ATOM   3072 C  CB  . ASN A 1 438 ? 5.424   -48.473 -33.689 1.00 42.55  ? 701  ASN A CB  1 
ATOM   3073 C  CG  . ASN A 1 438 ? 6.677   -47.672 -33.395 1.00 55.01  ? 701  ASN A CG  1 
ATOM   3074 O  OD1 . ASN A 1 438 ? 7.433   -47.994 -32.467 1.00 60.91  ? 701  ASN A OD1 1 
ATOM   3075 N  ND2 . ASN A 1 438 ? 6.827   -46.566 -34.112 1.00 44.05  ? 701  ASN A ND2 1 
ATOM   3076 N  N   . ASP A 1 439 ? 2.039   -48.827 -33.113 1.00 35.25  ? 702  ASP A N   1 
ATOM   3077 C  CA  . ASP A 1 439 ? 0.940   -49.763 -33.508 1.00 36.38  ? 702  ASP A CA  1 
ATOM   3078 C  C   . ASP A 1 439 ? -0.331  -49.237 -32.854 1.00 32.94  ? 702  ASP A C   1 
ATOM   3079 O  O   . ASP A 1 439 ? -0.297  -49.023 -31.627 1.00 32.10  ? 702  ASP A O   1 
ATOM   3080 C  CB  . ASP A 1 439 ? 1.417   -51.171 -33.158 1.00 41.81  ? 702  ASP A CB  1 
ATOM   3081 C  CG  . ASP A 1 439 ? 0.405   -52.293 -33.058 1.00 49.46  ? 702  ASP A CG  1 
ATOM   3082 O  OD1 . ASP A 1 439 ? -0.787  -52.096 -33.494 1.00 38.32  ? 702  ASP A OD1 1 
ATOM   3083 O  OD2 . ASP A 1 439 ? 0.831   -53.372 -32.470 1.00 51.77  ? 702  ASP A OD2 1 
ATOM   3084 N  N   . TRP A 1 440 ? -1.347  -48.943 -33.648 1.00 30.71  ? 703  TRP A N   1 
ATOM   3085 C  CA  . TRP A 1 440 ? -2.635  -48.371 -33.170 1.00 27.81  ? 703  TRP A CA  1 
ATOM   3086 C  C   . TRP A 1 440 ? -3.248  -49.269 -32.073 1.00 29.08  ? 703  TRP A C   1 
ATOM   3087 O  O   . TRP A 1 440 ? -3.987  -48.746 -31.217 1.00 26.41  ? 703  TRP A O   1 
ATOM   3088 C  CB  . TRP A 1 440 ? -3.573  -48.150 -34.363 1.00 29.37  ? 703  TRP A CB  1 
ATOM   3089 C  CG  . TRP A 1 440 ? -4.091  -49.402 -35.000 1.00 29.90  ? 703  TRP A CG  1 
ATOM   3090 C  CD1 . TRP A 1 440 ? -3.574  -50.027 -36.089 1.00 31.88  ? 703  TRP A CD1 1 
ATOM   3091 C  CD2 . TRP A 1 440 ? -5.242  -50.167 -34.631 1.00 29.34  ? 703  TRP A CD2 1 
ATOM   3092 N  NE1 . TRP A 1 440 ? -4.313  -51.121 -36.430 1.00 32.09  ? 703  TRP A NE1 1 
ATOM   3093 C  CE2 . TRP A 1 440 ? -5.320  -51.269 -35.515 1.00 27.95  ? 703  TRP A CE2 1 
ATOM   3094 C  CE3 . TRP A 1 440 ? -6.194  -50.073 -33.624 1.00 29.33  ? 703  TRP A CE3 1 
ATOM   3095 C  CZ2 . TRP A 1 440 ? -6.282  -52.272 -35.414 1.00 29.38  ? 703  TRP A CZ2 1 
ATOM   3096 C  CZ3 . TRP A 1 440 ? -7.182  -51.035 -33.561 1.00 28.78  ? 703  TRP A CZ3 1 
ATOM   3097 C  CH2 . TRP A 1 440 ? -7.231  -52.118 -34.430 1.00 31.13  ? 703  TRP A CH2 1 
ATOM   3098 N  N   . THR A 1 441 ? -2.933  -50.564 -32.050 1.00 24.05  ? 704  THR A N   1 
ATOM   3099 C  CA  . THR A 1 441 ? -3.484  -51.505 -31.010 1.00 26.41  ? 704  THR A CA  1 
ATOM   3100 C  C   . THR A 1 441 ? -2.822  -51.307 -29.656 1.00 26.88  ? 704  THR A C   1 
ATOM   3101 O  O   . THR A 1 441 ? -3.271  -51.952 -28.688 1.00 27.76  ? 704  THR A O   1 
ATOM   3102 C  CB  . THR A 1 441 ? -3.414  -52.981 -31.414 1.00 26.82  ? 704  THR A CB  1 
ATOM   3103 O  OG1 . THR A 1 441 ? -2.060  -53.416 -31.500 1.00 28.31  ? 704  THR A OG1 1 
ATOM   3104 C  CG2 . THR A 1 441 ? -4.084  -53.251 -32.749 1.00 25.81  ? 704  THR A CG2 1 
ATOM   3105 N  N   . GLN A 1 442 ? -1.772  -50.490 -29.557 1.00 26.58  ? 705  GLN A N   1 
ATOM   3106 C  CA  . GLN A 1 442 ? -1.064  -50.193 -28.299 1.00 27.58  ? 705  GLN A CA  1 
ATOM   3107 C  C   . GLN A 1 442 ? -1.427  -48.802 -27.779 1.00 24.13  ? 705  GLN A C   1 
ATOM   3108 O  O   . GLN A 1 442 ? -1.164  -48.561 -26.632 1.00 24.22  ? 705  GLN A O   1 
ATOM   3109 C  CB  . GLN A 1 442 ? 0.453   -50.297 -28.478 1.00 30.52  ? 705  GLN A CB  1 
ATOM   3110 C  CG  . GLN A 1 442 ? 0.840   -51.574 -29.202 1.00 36.29  ? 705  GLN A CG  1 
ATOM   3111 C  CD  . GLN A 1 442 ? 0.484   -52.773 -28.394 1.00 35.78  ? 705  GLN A CD  1 
ATOM   3112 O  OE1 . GLN A 1 442 ? 1.056   -52.931 -27.345 1.00 38.05  ? 705  GLN A OE1 1 
ATOM   3113 N  NE2 . GLN A 1 442 ? -0.396  -53.653 -28.892 1.00 40.44  ? 705  GLN A NE2 1 
ATOM   3114 N  N   . VAL A 1 443 ? -1.962  -47.952 -28.610 1.00 24.12  ? 706  VAL A N   1 
ATOM   3115 C  CA  . VAL A 1 443 ? -2.236  -46.526 -28.272 1.00 26.29  ? 706  VAL A CA  1 
ATOM   3116 C  C   . VAL A 1 443 ? -3.304  -46.444 -27.180 1.00 24.74  ? 706  VAL A C   1 
ATOM   3117 O  O   . VAL A 1 443 ? -4.368  -47.033 -27.292 1.00 24.96  ? 706  VAL A O   1 
ATOM   3118 C  CB  . VAL A 1 443 ? -2.724  -45.733 -29.499 1.00 30.26  ? 706  VAL A CB  1 
ATOM   3119 C  CG1 . VAL A 1 443 ? -3.112  -44.324 -29.139 1.00 35.75  ? 706  VAL A CG1 1 
ATOM   3120 C  CG2 . VAL A 1 443 ? -1.651  -45.687 -30.549 1.00 40.56  ? 706  VAL A CG2 1 
ATOM   3121 N  N   . PRO A 1 444 ? -3.072  -45.686 -26.095 1.00 25.39  ? 707  PRO A N   1 
ATOM   3122 C  CA  . PRO A 1 444 ? -4.138  -45.451 -25.116 1.00 22.89  ? 707  PRO A CA  1 
ATOM   3123 C  C   . PRO A 1 444 ? -5.121  -44.352 -25.594 1.00 24.75  ? 707  PRO A C   1 
ATOM   3124 O  O   . PRO A 1 444 ? -4.659  -43.369 -26.174 1.00 23.12  ? 707  PRO A O   1 
ATOM   3125 C  CB  . PRO A 1 444 ? -3.345  -44.953 -23.916 1.00 25.81  ? 707  PRO A CB  1 
ATOM   3126 C  CG  . PRO A 1 444 ? -2.109  -44.253 -24.529 1.00 23.95  ? 707  PRO A CG  1 
ATOM   3127 C  CD  . PRO A 1 444 ? -1.783  -45.053 -25.755 1.00 24.60  ? 707  PRO A CD  1 
ATOM   3128 N  N   . PHE A 1 445 ? -6.428  -44.536 -25.381 0.50 22.50  ? 708  PHE A N   1 
ATOM   3129 C  CA  . PHE A 1 445 ? -7.456  -43.491 -25.647 0.50 22.55  ? 708  PHE A CA  1 
ATOM   3130 C  C   . PHE A 1 445 ? -8.684  -43.786 -24.800 0.50 22.62  ? 708  PHE A C   1 
ATOM   3131 O  O   . PHE A 1 445 ? -9.091  -44.952 -24.746 0.50 21.95  ? 708  PHE A O   1 
ATOM   3132 C  CB  . PHE A 1 445 ? -7.824  -43.430 -27.133 0.50 21.74  ? 708  PHE A CB  1 
ATOM   3133 C  CG  . PHE A 1 445 ? -8.670  -42.249 -27.551 0.50 22.07  ? 708  PHE A CG  1 
ATOM   3134 C  CD1 . PHE A 1 445 ? -8.306  -40.955 -27.213 0.50 21.45  ? 708  PHE A CD1 1 
ATOM   3135 C  CD2 . PHE A 1 445 ? -9.835  -42.427 -28.285 0.50 21.96  ? 708  PHE A CD2 1 
ATOM   3136 C  CE1 . PHE A 1 445 ? -9.064  -39.865 -27.613 0.50 20.62  ? 708  PHE A CE1 1 
ATOM   3137 C  CE2 . PHE A 1 445 ? -10.590 -41.336 -28.691 0.50 22.39  ? 708  PHE A CE2 1 
ATOM   3138 C  CZ  . PHE A 1 445 ? -10.198 -40.051 -28.364 0.50 21.11  ? 708  PHE A CZ  1 
ATOM   3139 N  N   . CYS A 1 446 ? -9.224  -42.750 -24.156 1.00 24.53  ? 709  CYS A N   1 
ATOM   3140 C  CA  . CYS A 1 446 ? -10.498 -42.837 -23.341 1.00 24.19  ? 709  CYS A CA  1 
ATOM   3141 C  C   . CYS A 1 446 ? -10.406 -44.024 -22.381 1.00 24.81  ? 709  CYS A C   1 
ATOM   3142 O  O   . CYS A 1 446 ? -11.357 -44.826 -22.414 1.00 24.86  ? 709  CYS A O   1 
ATOM   3143 C  CB  . CYS A 1 446 ? -11.676 -42.940 -24.303 1.00 25.52  ? 709  CYS A CB  1 
ATOM   3144 S  SG  . CYS A 1 446 ? -11.887 -41.397 -25.238 1.00 29.83  ? 709  CYS A SG  1 
ATOM   3145 N  N   . SER A 1 447 ? -9.261  -44.179 -21.720 1.00 25.88  ? 710  SER A N   1 
ATOM   3146 C  CA  . SER A 1 447 ? -8.995  -45.200 -20.670 1.00 28.72  ? 710  SER A CA  1 
ATOM   3147 C  C   . SER A 1 447 ? -8.922  -46.616 -21.252 1.00 26.52  ? 710  SER A C   1 
ATOM   3148 O  O   . SER A 1 447 ? -8.804  -47.549 -20.447 1.00 30.57  ? 710  SER A O   1 
ATOM   3149 C  CB  . SER A 1 447 ? -10.063 -45.154 -19.604 1.00 34.24  ? 710  SER A CB  1 
ATOM   3150 O  OG  . SER A 1 447 ? -10.149 -43.869 -19.057 1.00 36.47  ? 710  SER A OG  1 
ATOM   3151 N  N   . HIS A 1 448 ? -8.872  -46.788 -22.577 1.00 22.00  ? 711  HIS A N   1 
ATOM   3152 C  CA  . HIS A 1 448 ? -8.874  -48.116 -23.257 1.00 21.12  ? 711  HIS A CA  1 
ATOM   3153 C  C   . HIS A 1 448 ? -7.659  -48.282 -24.184 1.00 19.68  ? 711  HIS A C   1 
ATOM   3154 O  O   . HIS A 1 448 ? -6.943  -47.268 -24.522 1.00 21.79  ? 711  HIS A O   1 
ATOM   3155 C  CB  . HIS A 1 448 ? -10.166 -48.329 -24.050 1.00 19.59  ? 711  HIS A CB  1 
ATOM   3156 C  CG  . HIS A 1 448 ? -11.351 -48.521 -23.163 1.00 20.88  ? 711  HIS A CG  1 
ATOM   3157 N  ND1 . HIS A 1 448 ? -11.961 -47.475 -22.475 1.00 22.39  ? 711  HIS A ND1 1 
ATOM   3158 C  CD2 . HIS A 1 448 ? -12.065 -49.650 -22.897 1.00 20.30  ? 711  HIS A CD2 1 
ATOM   3159 C  CE1 . HIS A 1 448 ? -12.968 -47.978 -21.749 1.00 22.64  ? 711  HIS A CE1 1 
ATOM   3160 N  NE2 . HIS A 1 448 ? -13.035 -49.344 -21.958 1.00 21.37  ? 711  HIS A NE2 1 
ATOM   3161 N  N   . HIS A 1 449 ? -7.419  -49.513 -24.573 1.00 20.14  ? 712  HIS A N   1 
ATOM   3162 C  CA  . HIS A 1 449 ? -6.709  -49.890 -25.830 1.00 21.13  ? 712  HIS A CA  1 
ATOM   3163 C  C   . HIS A 1 449 ? -7.630  -50.790 -26.628 1.00 21.96  ? 712  HIS A C   1 
ATOM   3164 O  O   . HIS A 1 449 ? -8.686  -51.132 -26.117 1.00 23.35  ? 712  HIS A O   1 
ATOM   3165 C  CB  . HIS A 1 449 ? -5.392  -50.640 -25.568 1.00 20.41  ? 712  HIS A CB  1 
ATOM   3166 C  CG  . HIS A 1 449 ? -5.577  -51.845 -24.701 1.00 20.33  ? 712  HIS A CG  1 
ATOM   3167 N  ND1 . HIS A 1 449 ? -5.738  -51.733 -23.339 1.00 21.43  ? 712  HIS A ND1 1 
ATOM   3168 C  CD2 . HIS A 1 449 ? -5.743  -53.137 -24.996 1.00 21.08  ? 712  HIS A CD2 1 
ATOM   3169 C  CE1 . HIS A 1 449 ? -5.994  -52.929 -22.830 1.00 21.45  ? 712  HIS A CE1 1 
ATOM   3170 N  NE2 . HIS A 1 449 ? -5.983  -53.814 -23.818 1.00 20.83  ? 712  HIS A NE2 1 
ATOM   3171 N  N   . PHE A 1 450 ? -7.257  -51.128 -27.851 1.00 21.74  ? 713  PHE A N   1 
ATOM   3172 C  CA  . PHE A 1 450 ? -8.157  -51.766 -28.834 1.00 23.66  ? 713  PHE A CA  1 
ATOM   3173 C  C   . PHE A 1 450 ? -7.489  -52.968 -29.479 1.00 23.15  ? 713  PHE A C   1 
ATOM   3174 O  O   . PHE A 1 450 ? -6.268  -52.893 -29.841 1.00 24.35  ? 713  PHE A O   1 
ATOM   3175 C  CB  . PHE A 1 450 ? -8.639  -50.692 -29.816 1.00 25.04  ? 713  PHE A CB  1 
ATOM   3176 C  CG  . PHE A 1 450 ? -9.357  -49.564 -29.115 1.00 21.67  ? 713  PHE A CG  1 
ATOM   3177 C  CD1 . PHE A 1 450 ? -8.660  -48.495 -28.595 1.00 24.61  ? 713  PHE A CD1 1 
ATOM   3178 C  CD2 . PHE A 1 450 ? -10.724 -49.613 -28.924 1.00 26.02  ? 713  PHE A CD2 1 
ATOM   3179 C  CE1 . PHE A 1 450 ? -9.331  -47.482 -27.915 1.00 24.42  ? 713  PHE A CE1 1 
ATOM   3180 C  CE2 . PHE A 1 450 ? -11.385 -48.649 -28.168 1.00 24.77  ? 713  PHE A CE2 1 
ATOM   3181 C  CZ  . PHE A 1 450 ? -10.695 -47.554 -27.735 1.00 25.51  ? 713  PHE A CZ  1 
ATOM   3182 N  N   . HIS A 1 451 ? -8.210  -54.093 -29.552 1.00 22.84  ? 714  HIS A N   1 
ATOM   3183 C  CA  . HIS A 1 451 ? -7.694  -55.337 -30.177 1.00 22.00  ? 714  HIS A CA  1 
ATOM   3184 C  C   . HIS A 1 451 ? -8.339  -55.578 -31.537 1.00 24.34  ? 714  HIS A C   1 
ATOM   3185 O  O   . HIS A 1 451 ? -9.530  -55.258 -31.735 1.00 25.81  ? 714  HIS A O   1 
ATOM   3186 C  CB  . HIS A 1 451 ? -7.917  -56.521 -29.216 1.00 22.19  ? 714  HIS A CB  1 
ATOM   3187 C  CG  . HIS A 1 451 ? -7.179  -56.476 -27.907 1.00 20.65  ? 714  HIS A CG  1 
ATOM   3188 N  ND1 . HIS A 1 451 ? -6.060  -57.245 -27.669 1.00 21.29  ? 714  HIS A ND1 1 
ATOM   3189 C  CD2 . HIS A 1 451 ? -7.455  -55.863 -26.727 1.00 25.14  ? 714  HIS A CD2 1 
ATOM   3190 C  CE1 . HIS A 1 451 ? -5.687  -57.093 -26.391 1.00 22.66  ? 714  HIS A CE1 1 
ATOM   3191 N  NE2 . HIS A 1 451 ? -6.493  -56.220 -25.797 1.00 17.90  ? 714  HIS A NE2 1 
ATOM   3192 N  N   . GLU A 1 452 ? -7.593  -56.167 -32.480 1.00 27.00  ? 715  GLU A N   1 
ATOM   3193 C  CA  . GLU A 1 452 ? -8.128  -56.653 -33.761 1.00 29.12  ? 715  GLU A CA  1 
ATOM   3194 C  C   . GLU A 1 452 ? -8.466  -58.127 -33.566 1.00 29.89  ? 715  GLU A C   1 
ATOM   3195 O  O   . GLU A 1 452 ? -7.630  -58.872 -33.129 1.00 32.78  ? 715  GLU A O   1 
ATOM   3196 C  CB  . GLU A 1 452 ? -7.154  -56.459 -34.928 1.00 33.42  ? 715  GLU A CB  1 
ATOM   3197 C  CG  . GLU A 1 452 ? -7.831  -55.761 -36.089 1.00 40.09  ? 715  GLU A CG  1 
ATOM   3198 C  CD  . GLU A 1 452 ? -6.977  -55.540 -37.337 1.00 46.08  ? 715  GLU A CD  1 
ATOM   3199 O  OE1 . GLU A 1 452 ? -7.382  -54.735 -38.221 1.00 39.95  ? 715  GLU A OE1 1 
ATOM   3200 O  OE2 . GLU A 1 452 ? -5.939  -56.225 -37.442 1.00 54.60  ? 715  GLU A OE2 1 
ATOM   3201 N  N   . LEU A 1 453 ? -9.721  -58.503 -33.687 1.00 27.22  ? 716  LEU A N   1 
ATOM   3202 C  CA  . LEU A 1 453 ? -10.171 -59.872 -33.291 1.00 31.67  ? 716  LEU A CA  1 
ATOM   3203 C  C   . LEU A 1 453 ? -10.883 -60.520 -34.489 1.00 35.26  ? 716  LEU A C   1 
ATOM   3204 O  O   . LEU A 1 453 ? -11.821 -59.891 -35.092 1.00 31.14  ? 716  LEU A O   1 
ATOM   3205 C  CB  . LEU A 1 453 ? -11.065 -59.642 -32.066 1.00 32.21  ? 716  LEU A CB  1 
ATOM   3206 C  CG  . LEU A 1 453 ? -11.823 -60.844 -31.546 1.00 38.20  ? 716  LEU A CG  1 
ATOM   3207 C  CD1 . LEU A 1 453 ? -10.869 -61.960 -31.211 1.00 38.70  ? 716  LEU A CD1 1 
ATOM   3208 C  CD2 . LEU A 1 453 ? -12.646 -60.449 -30.320 1.00 36.56  ? 716  LEU A CD2 1 
ATOM   3209 N  N   . ILE A 1 454 ? -10.405 -61.682 -34.923 1.00 34.86  ? 717  ILE A N   1 
ATOM   3210 C  CA  . ILE A 1 454 ? -10.893 -62.263 -36.196 1.00 33.35  ? 717  ILE A CA  1 
ATOM   3211 C  C   . ILE A 1 454 ? -11.861 -63.390 -35.863 1.00 32.81  ? 717  ILE A C   1 
ATOM   3212 O  O   . ILE A 1 454 ? -11.561 -64.228 -34.956 1.00 33.57  ? 717  ILE A O   1 
ATOM   3213 C  CB  . ILE A 1 454 ? -9.730  -62.687 -37.119 1.00 45.23  ? 717  ILE A CB  1 
ATOM   3214 C  CG1 . ILE A 1 454 ? -8.915  -61.464 -37.571 1.00 45.46  ? 717  ILE A CG1 1 
ATOM   3215 C  CG2 . ILE A 1 454 ? -10.244 -63.469 -38.332 1.00 46.70  ? 717  ILE A CG2 1 
ATOM   3216 C  CD1 . ILE A 1 454 ? -7.710  -61.820 -38.383 1.00 49.56  ? 717  ILE A CD1 1 
ATOM   3217 N  N   . MET A 1 455 ? -13.056 -63.280 -36.432 1.00 31.28  ? 718  MET A N   1 
ATOM   3218 C  CA  . MET A 1 455 ? -14.151 -64.252 -36.192 1.00 34.40  ? 718  MET A CA  1 
ATOM   3219 C  C   . MET A 1 455 ? -13.851 -65.533 -36.957 1.00 35.67  ? 718  MET A C   1 
ATOM   3220 O  O   . MET A 1 455 ? -13.229 -65.479 -38.055 1.00 34.33  ? 718  MET A O   1 
ATOM   3221 C  CB  . MET A 1 455 ? -15.495 -63.684 -36.630 1.00 33.30  ? 718  MET A CB  1 
ATOM   3222 C  CG  . MET A 1 455 ? -15.931 -62.538 -35.756 1.00 33.80  ? 718  MET A CG  1 
ATOM   3223 S  SD  . MET A 1 455 ? -17.437 -61.708 -36.306 1.00 35.50  ? 718  MET A SD  1 
ATOM   3224 C  CE  . MET A 1 455 ? -18.658 -62.985 -35.999 1.00 38.59  ? 718  MET A CE  1 
ATOM   3225 N  N   A LYS A 1 456 ? -14.275 -66.667 -36.403 0.24 36.42  ? 719  LYS A N   1 
ATOM   3226 N  N   B LYS A 1 456 ? -14.279 -66.670 -36.405 0.24 36.15  ? 719  LYS A N   1 
ATOM   3227 C  CA  A LYS A 1 456 ? -14.096 -68.000 -37.042 0.24 39.30  ? 719  LYS A CA  1 
ATOM   3228 C  CA  B LYS A 1 456 ? -14.103 -68.001 -37.049 0.24 38.87  ? 719  LYS A CA  1 
ATOM   3229 C  C   A LYS A 1 456 ? -14.521 -67.919 -38.515 0.24 37.91  ? 719  LYS A C   1 
ATOM   3230 C  C   B LYS A 1 456 ? -14.497 -67.895 -38.526 0.24 37.67  ? 719  LYS A C   1 
ATOM   3231 O  O   A LYS A 1 456 ? -13.916 -68.637 -39.329 0.24 41.30  ? 719  LYS A O   1 
ATOM   3232 O  O   B LYS A 1 456 ? -13.852 -68.568 -39.351 0.24 40.62  ? 719  LYS A O   1 
ATOM   3233 C  CB  A LYS A 1 456 ? -14.854 -69.076 -36.263 0.24 39.81  ? 719  LYS A CB  1 
ATOM   3234 C  CB  B LYS A 1 456 ? -14.917 -69.085 -36.338 0.24 39.04  ? 719  LYS A CB  1 
ATOM   3235 C  CG  A LYS A 1 456 ? -14.019 -69.802 -35.215 0.24 43.39  ? 719  LYS A CG  1 
ATOM   3236 C  CG  B LYS A 1 456 ? -14.797 -70.474 -36.957 0.24 42.58  ? 719  LYS A CG  1 
ATOM   3237 C  CD  A LYS A 1 456 ? -14.850 -70.532 -34.180 0.24 44.92  ? 719  LYS A CD  1 
ATOM   3238 C  CD  B LYS A 1 456 ? -14.928 -71.605 -35.958 0.24 41.93  ? 719  LYS A CD  1 
ATOM   3239 C  CE  A LYS A 1 456 ? -15.182 -69.684 -32.969 0.24 44.41  ? 719  LYS A CE  1 
ATOM   3240 C  CE  B LYS A 1 456 ? -15.181 -72.946 -36.615 0.24 43.24  ? 719  LYS A CE  1 
ATOM   3241 N  NZ  A LYS A 1 456 ? -16.540 -69.984 -32.457 0.24 42.81  ? 719  LYS A NZ  1 
ATOM   3242 N  NZ  B LYS A 1 456 ? -14.819 -74.071 -35.718 0.24 44.96  ? 719  LYS A NZ  1 
ATOM   3243 N  N   . ASP A 1 457 ? -15.472 -67.040 -38.850 1.00 36.71  ? 720  ASP A N   1 
ATOM   3244 C  CA  . ASP A 1 457 ? -15.949 -66.845 -40.252 1.00 35.95  ? 720  ASP A CA  1 
ATOM   3245 C  C   . ASP A 1 457 ? -15.125 -65.809 -41.055 1.00 47.44  ? 720  ASP A C   1 
ATOM   3246 O  O   . ASP A 1 457 ? -15.549 -65.458 -42.195 1.00 41.27  ? 720  ASP A O   1 
ATOM   3247 C  CB  . ASP A 1 457 ? -17.456 -66.511 -40.266 1.00 39.26  ? 720  ASP A CB  1 
ATOM   3248 C  CG  . ASP A 1 457 ? -17.881 -65.151 -39.716 1.00 41.24  ? 720  ASP A CG  1 
ATOM   3249 O  OD1 . ASP A 1 457 ? -17.060 -64.209 -39.726 1.00 37.86  ? 720  ASP A OD1 1 
ATOM   3250 O  OD2 . ASP A 1 457 ? -19.044 -65.038 -39.320 1.00 39.13  ? 720  ASP A OD2 1 
ATOM   3251 N  N   . GLY A 1 458 ? -14.010 -65.285 -40.518 1.00 44.22  ? 721  GLY A N   1 
ATOM   3252 C  CA  . GLY A 1 458 ? -13.107 -64.398 -41.280 1.00 40.03  ? 721  GLY A CA  1 
ATOM   3253 C  C   . GLY A 1 458 ? -13.397 -62.923 -41.103 1.00 39.20  ? 721  GLY A C   1 
ATOM   3254 O  O   . GLY A 1 458 ? -12.549 -62.125 -41.467 1.00 45.70  ? 721  GLY A O   1 
ATOM   3255 N  N   . ARG A 1 459 ? -14.533 -62.528 -40.533 1.00 36.16  ? 722  ARG A N   1 
ATOM   3256 C  CA  . ARG A 1 459 ? -14.864 -61.092 -40.389 1.00 33.38  ? 722  ARG A CA  1 
ATOM   3257 C  C   . ARG A 1 459 ? -14.044 -60.517 -39.212 1.00 31.29  ? 722  ARG A C   1 
ATOM   3258 O  O   . ARG A 1 459 ? -13.612 -61.277 -38.290 1.00 33.05  ? 722  ARG A O   1 
ATOM   3259 C  CB  . ARG A 1 459 ? -16.363 -60.886 -40.224 1.00 35.80  ? 722  ARG A CB  1 
ATOM   3260 C  CG  . ARG A 1 459 ? -17.202 -61.337 -41.427 1.00 36.81  ? 722  ARG A CG  1 
ATOM   3261 C  CD  . ARG A 1 459 ? -18.675 -61.026 -41.234 1.00 39.98  ? 722  ARG A CD  1 
ATOM   3262 N  NE  . ARG A 1 459 ? -19.300 -61.896 -40.251 1.00 34.45  ? 722  ARG A NE  1 
ATOM   3263 C  CZ  . ARG A 1 459 ? -20.579 -61.863 -39.952 1.00 32.65  ? 722  ARG A CZ  1 
ATOM   3264 N  NH1 . ARG A 1 459 ? -21.374 -60.982 -40.537 1.00 36.48  ? 722  ARG A NH1 1 
ATOM   3265 N  NH2 . ARG A 1 459 ? -21.069 -62.735 -39.096 1.00 35.36  ? 722  ARG A NH2 1 
ATOM   3266 N  N   . VAL A 1 460 ? -13.818 -59.233 -39.274 1.00 32.69  ? 723  VAL A N   1 
ATOM   3267 C  CA  . VAL A 1 460 ? -12.902 -58.508 -38.357 1.00 33.36  ? 723  VAL A CA  1 
ATOM   3268 C  C   . VAL A 1 460 ? -13.660 -57.605 -37.396 1.00 32.03  ? 723  VAL A C   1 
ATOM   3269 O  O   . VAL A 1 460 ? -14.324 -56.666 -37.821 1.00 39.00  ? 723  VAL A O   1 
ATOM   3270 C  CB  . VAL A 1 460 ? -11.857 -57.718 -39.155 1.00 37.12  ? 723  VAL A CB  1 
ATOM   3271 C  CG1 . VAL A 1 460 ? -10.872 -57.070 -38.198 1.00 41.76  ? 723  VAL A CG1 1 
ATOM   3272 C  CG2 . VAL A 1 460 ? -11.133 -58.627 -40.142 1.00 36.98  ? 723  VAL A CG2 1 
ATOM   3273 N  N   . LEU A 1 461 ? -13.454 -57.839 -36.093 1.00 29.94  ? 724  LEU A N   1 
ATOM   3274 C  CA  . LEU A 1 461 ? -13.954 -56.945 -35.026 1.00 27.09  ? 724  LEU A CA  1 
ATOM   3275 C  C   . LEU A 1 461 ? -12.772 -56.120 -34.486 1.00 27.57  ? 724  LEU A C   1 
ATOM   3276 O  O   . LEU A 1 461 ? -11.644 -56.688 -34.294 1.00 28.32  ? 724  LEU A O   1 
ATOM   3277 C  CB  . LEU A 1 461 ? -14.568 -57.806 -33.947 1.00 27.23  ? 724  LEU A CB  1 
ATOM   3278 C  CG  . LEU A 1 461 ? -15.767 -58.653 -34.357 1.00 27.29  ? 724  LEU A CG  1 
ATOM   3279 C  CD1 . LEU A 1 461 ? -16.062 -59.602 -33.229 1.00 28.96  ? 724  LEU A CD1 1 
ATOM   3280 C  CD2 . LEU A 1 461 ? -16.963 -57.824 -34.693 1.00 26.85  ? 724  LEU A CD2 1 
ATOM   3281 N  N   . VAL A 1 462 ? -12.998 -54.838 -34.240 1.00 23.18  ? 725  VAL A N   1 
ATOM   3282 C  CA  . VAL A 1 462 ? -12.054 -54.009 -33.438 1.00 23.22  ? 725  VAL A CA  1 
ATOM   3283 C  C   . VAL A 1 462 ? -12.738 -53.714 -32.107 1.00 20.12  ? 725  VAL A C   1 
ATOM   3284 O  O   . VAL A 1 462 ? -13.750 -53.039 -32.097 1.00 23.09  ? 725  VAL A O   1 
ATOM   3285 C  CB  . VAL A 1 462 ? -11.610 -52.769 -34.215 1.00 25.11  ? 725  VAL A CB  1 
ATOM   3286 C  CG1 . VAL A 1 462 ? -10.702 -51.920 -33.338 1.00 25.35  ? 725  VAL A CG1 1 
ATOM   3287 C  CG2 . VAL A 1 462 ? -10.941 -53.157 -35.534 1.00 27.53  ? 725  VAL A CG2 1 
ATOM   3288 N  N   . VAL A 1 463 ? -12.199 -54.242 -31.016 1.00 22.90  ? 726  VAL A N   1 
ATOM   3289 C  CA  . VAL A 1 463 ? -12.885 -54.265 -29.705 1.00 21.83  ? 726  VAL A CA  1 
ATOM   3290 C  C   . VAL A 1 463 ? -12.142 -53.449 -28.670 1.00 21.00  ? 726  VAL A C   1 
ATOM   3291 O  O   . VAL A 1 463 ? -10.905 -53.364 -28.657 1.00 24.04  ? 726  VAL A O   1 
ATOM   3292 C  CB  . VAL A 1 463 ? -13.105 -55.696 -29.219 1.00 22.19  ? 726  VAL A CB  1 
ATOM   3293 C  CG1 . VAL A 1 463 ? -13.905 -56.498 -30.232 1.00 22.91  ? 726  VAL A CG1 1 
ATOM   3294 C  CG2 . VAL A 1 463 ? -11.792 -56.410 -28.967 1.00 21.52  ? 726  VAL A CG2 1 
ATOM   3295 N  N   . PRO A 1 464 ? -12.911 -52.802 -27.771 1.00 22.81  ? 727  PRO A N   1 
ATOM   3296 C  CA  . PRO A 1 464 ? -12.326 -52.045 -26.649 1.00 20.62  ? 727  PRO A CA  1 
ATOM   3297 C  C   . PRO A 1 464 ? -11.876 -52.982 -25.524 1.00 18.80  ? 727  PRO A C   1 
ATOM   3298 O  O   . PRO A 1 464 ? -12.452 -54.081 -25.283 1.00 21.67  ? 727  PRO A O   1 
ATOM   3299 C  CB  . PRO A 1 464 ? -13.497 -51.197 -26.197 1.00 20.58  ? 727  PRO A CB  1 
ATOM   3300 C  CG  . PRO A 1 464 ? -14.691 -52.145 -26.421 1.00 20.30  ? 727  PRO A CG  1 
ATOM   3301 C  CD  . PRO A 1 464 ? -14.374 -52.771 -27.772 1.00 22.02  ? 727  PRO A CD  1 
ATOM   3302 N  N   . CYS A 1 465 ? -10.872 -52.556 -24.777 1.00 20.06  ? 728  CYS A N   1 
ATOM   3303 C  CA  . CYS A 1 465 ? -10.237 -53.396 -23.730 1.00 18.97  ? 728  CYS A CA  1 
ATOM   3304 C  C   . CYS A 1 465 ? -9.562  -52.512 -22.697 1.00 21.58  ? 728  CYS A C   1 
ATOM   3305 O  O   . CYS A 1 465 ? -9.132  -51.441 -23.020 1.00 21.08  ? 728  CYS A O   1 
ATOM   3306 C  CB  . CYS A 1 465 ? -9.262  -54.430 -24.309 1.00 19.07  ? 728  CYS A CB  1 
ATOM   3307 S  SG  . CYS A 1 465 ? -8.763  -55.722 -23.123 1.00 21.72  ? 728  CYS A SG  1 
ATOM   3308 N  N   . ARG A 1 466 ? -9.556  -52.960 -21.432 1.00 21.99  ? 729  ARG A N   1 
ATOM   3309 C  CA  . ARG A 1 466 ? -8.664  -52.389 -20.439 1.00 23.97  ? 729  ARG A CA  1 
ATOM   3310 C  C   . ARG A 1 466 ? -8.400  -53.447 -19.398 1.00 21.85  ? 729  ARG A C   1 
ATOM   3311 O  O   . ARG A 1 466 ? -8.957  -54.550 -19.476 1.00 20.12  ? 729  ARG A O   1 
ATOM   3312 C  CB  . ARG A 1 466 ? -9.209  -51.123 -19.798 1.00 28.65  ? 729  ARG A CB  1 
ATOM   3313 C  CG  . ARG A 1 466 ? -10.534 -51.307 -19.121 1.00 34.08  ? 729  ARG A CG  1 
ATOM   3314 C  CD  . ARG A 1 466 ? -11.245 -49.970 -18.806 1.00 28.71  ? 729  ARG A CD  1 
ATOM   3315 N  NE  . ARG A 1 466 ? -10.656 -49.231 -17.703 1.00 29.87  ? 729  ARG A NE  1 
ATOM   3316 C  CZ  . ARG A 1 466 ? -11.187 -48.085 -17.249 1.00 32.66  ? 729  ARG A CZ  1 
ATOM   3317 N  NH1 . ARG A 1 466 ? -12.334 -47.634 -17.744 1.00 32.34  ? 729  ARG A NH1 1 
ATOM   3318 N  NH2 . ARG A 1 466 ? -10.581 -47.421 -16.313 1.00 33.87  ? 729  ARG A NH2 1 
ATOM   3319 N  N   . ASN A 1 467 ? -7.461  -53.155 -18.508 1.00 21.44  ? 730  ASN A N   1 
ATOM   3320 C  CA  . ASN A 1 467 ? -7.053  -54.156 -17.503 1.00 24.31  ? 730  ASN A CA  1 
ATOM   3321 C  C   . ASN A 1 467 ? -8.319  -54.633 -16.746 1.00 21.07  ? 730  ASN A C   1 
ATOM   3322 O  O   . ASN A 1 467 ? -9.063  -53.807 -16.268 1.00 19.87  ? 730  ASN A O   1 
ATOM   3323 C  CB  . ASN A 1 467 ? -6.014  -53.577 -16.544 1.00 23.41  ? 730  ASN A CB  1 
ATOM   3324 C  CG  . ASN A 1 467 ? -5.662  -54.642 -15.524 1.00 28.72  ? 730  ASN A CG  1 
ATOM   3325 O  OD1 . ASN A 1 467 ? -6.348  -54.735 -14.512 1.00 26.83  ? 730  ASN A OD1 1 
ATOM   3326 N  ND2 . ASN A 1 467 ? -4.766  -55.558 -15.884 1.00 30.31  ? 730  ASN A ND2 1 
ATOM   3327 N  N   . GLN A 1 468 ? -8.526  -55.950 -16.601 1.00 20.55  ? 731  GLN A N   1 
ATOM   3328 C  CA  . GLN A 1 468 ? -9.802  -56.532 -16.156 1.00 23.08  ? 731  GLN A CA  1 
ATOM   3329 C  C   . GLN A 1 468 ? -10.027 -56.195 -14.688 1.00 21.95  ? 731  GLN A C   1 
ATOM   3330 O  O   . GLN A 1 468 ? -11.221 -56.066 -14.283 1.00 21.92  ? 731  GLN A O   1 
ATOM   3331 C  CB  . GLN A 1 468 ? -9.806  -58.017 -16.453 1.00 24.24  ? 731  GLN A CB  1 
ATOM   3332 C  CG  . GLN A 1 468 ? -11.172 -58.647 -16.298 1.00 24.41  ? 731  GLN A CG  1 
ATOM   3333 C  CD  . GLN A 1 468 ? -11.179 -60.143 -16.473 1.00 21.13  ? 731  GLN A CD  1 
ATOM   3334 O  OE1 . GLN A 1 468 ? -11.471 -60.647 -17.550 1.00 25.37  ? 731  GLN A OE1 1 
ATOM   3335 N  NE2 . GLN A 1 468 ? -10.801 -60.861 -15.446 1.00 21.14  ? 731  GLN A NE2 1 
ATOM   3336 N  N   . ASP A 1 469 ? -8.947  -56.000 -13.921 1.00 22.70  ? 732  ASP A N   1 
ATOM   3337 C  CA  . ASP A 1 469 ? -9.129  -55.620 -12.490 1.00 23.80  ? 732  ASP A CA  1 
ATOM   3338 C  C   . ASP A 1 469 ? -9.853  -54.284 -12.413 1.00 22.97  ? 732  ASP A C   1 
ATOM   3339 O  O   . ASP A 1 469 ? -10.682 -54.077 -11.476 1.00 22.02  ? 732  ASP A O   1 
ATOM   3340 C  CB  . ASP A 1 469 ? -7.812  -55.530 -11.716 1.00 23.09  ? 732  ASP A CB  1 
ATOM   3341 C  CG  . ASP A 1 469 ? -7.092  -56.839 -11.544 1.00 25.47  ? 732  ASP A CG  1 
ATOM   3342 O  OD1 . ASP A 1 469 ? -7.712  -57.890 -11.684 1.00 25.91  ? 732  ASP A OD1 1 
ATOM   3343 O  OD2 . ASP A 1 469 ? -5.885  -56.768 -11.307 1.00 30.04  ? 732  ASP A OD2 1 
ATOM   3344 N  N   . GLU A 1 470 ? -9.623  -53.370 -13.337 1.00 23.24  ? 733  GLU A N   1 
ATOM   3345 C  CA  . GLU A 1 470 ? -10.292 -52.046 -13.289 1.00 22.45  ? 733  GLU A CA  1 
ATOM   3346 C  C   . GLU A 1 470 ? -11.789 -52.224 -13.606 1.00 20.88  ? 733  GLU A C   1 
ATOM   3347 O  O   . GLU A 1 470 ? -12.667 -51.526 -13.039 1.00 24.02  ? 733  GLU A O   1 
ATOM   3348 C  CB  . GLU A 1 470 ? -9.750  -51.136 -14.409 1.00 22.90  ? 733  GLU A CB  1 
ATOM   3349 C  CG  . GLU A 1 470 ? -8.274  -50.879 -14.351 1.00 29.06  ? 733  GLU A CG  1 
ATOM   3350 C  CD  . GLU A 1 470 ? -7.674  -50.024 -15.477 1.00 36.25  ? 733  GLU A CD  1 
ATOM   3351 O  OE1 . GLU A 1 470 ? -6.462  -49.958 -15.509 1.00 42.30  ? 733  GLU A OE1 1 
ATOM   3352 O  OE2 . GLU A 1 470 ? -8.397  -49.497 -16.371 1.00 34.09  ? 733  GLU A OE2 1 
ATOM   3353 N  N   . LEU A 1 471 ? -12.130 -53.088 -14.568 1.00 22.16  ? 734  LEU A N   1 
ATOM   3354 C  CA  . LEU A 1 471 ? -13.521 -53.350 -14.939 1.00 20.72  ? 734  LEU A CA  1 
ATOM   3355 C  C   . LEU A 1 471 ? -14.311 -54.006 -13.797 1.00 22.24  ? 734  LEU A C   1 
ATOM   3356 O  O   . LEU A 1 471 ? -15.411 -53.507 -13.412 1.00 22.73  ? 734  LEU A O   1 
ATOM   3357 C  CB  . LEU A 1 471 ? -13.574 -54.193 -16.199 1.00 20.01  ? 734  LEU A CB  1 
ATOM   3358 C  CG  . LEU A 1 471 ? -13.061 -53.482 -17.450 1.00 21.40  ? 734  LEU A CG  1 
ATOM   3359 C  CD1 . LEU A 1 471 ? -12.932 -54.471 -18.591 1.00 23.70  ? 734  LEU A CD1 1 
ATOM   3360 C  CD2 . LEU A 1 471 ? -13.936 -52.335 -17.920 1.00 26.36  ? 734  LEU A CD2 1 
ATOM   3361 N  N   . ILE A 1 472 ? -13.740 -55.044 -13.201 1.00 20.57  ? 735  ILE A N   1 
ATOM   3362 C  CA  . ILE A 1 472 ? -14.396 -55.754 -12.070 1.00 21.83  ? 735  ILE A CA  1 
ATOM   3363 C  C   . ILE A 1 472 ? -14.509 -54.840 -10.865 1.00 21.17  ? 735  ILE A C   1 
ATOM   3364 O  O   . ILE A 1 472 ? -15.571 -54.870 -10.207 1.00 20.95  ? 735  ILE A O   1 
ATOM   3365 C  CB  . ILE A 1 472 ? -13.670 -57.045 -11.757 1.00 20.58  ? 735  ILE A CB  1 
ATOM   3366 C  CG1 . ILE A 1 472 ? -13.837 -57.944 -12.976 1.00 24.06  ? 735  ILE A CG1 1 
ATOM   3367 C  CG2 . ILE A 1 472 ? -14.178 -57.656 -10.450 1.00 22.74  ? 735  ILE A CG2 1 
ATOM   3368 C  CD1 . ILE A 1 472 ? -13.270 -59.311 -12.885 1.00 25.80  ? 735  ILE A CD1 1 
ATOM   3369 N  N   . GLY A 1 473 ? -13.417 -54.137 -10.527 1.00 21.76  ? 736  GLY A N   1 
ATOM   3370 C  CA  . GLY A 1 473 ? -13.441 -53.236 -9.370  1.00 21.97  ? 736  GLY A CA  1 
ATOM   3371 C  C   . GLY A 1 473 ? -14.466 -52.110 -9.496  1.00 24.84  ? 736  GLY A C   1 
ATOM   3372 O  O   . GLY A 1 473 ? -15.170 -51.762 -8.489  1.00 23.07  ? 736  GLY A O   1 
ATOM   3373 N  N   . ARG A 1 474 ? -14.662 -51.592 -10.697 1.00 21.23  ? 737  ARG A N   1 
ATOM   3374 C  CA  . ARG A 1 474 ? -15.684 -50.525 -10.905 1.00 23.47  ? 737  ARG A CA  1 
ATOM   3375 C  C   . ARG A 1 474 ? -17.108 -51.118 -10.755 1.00 23.15  ? 737  ARG A C   1 
ATOM   3376 O  O   . ARG A 1 474 ? -17.984 -50.454 -10.203 1.00 24.13  ? 737  ARG A O   1 
ATOM   3377 C  CB  . ARG A 1 474 ? -15.526 -49.944 -12.333 1.00 28.51  ? 737  ARG A CB  1 
ATOM   3378 C  CG  . ARG A 1 474 ? -14.182 -49.301 -12.637 1.00 42.20  ? 737  ARG A CG  1 
ATOM   3379 C  CD  . ARG A 1 474 ? -13.818 -49.231 -14.154 1.00 50.57  ? 737  ARG A CD  1 
ATOM   3380 N  NE  . ARG A 1 474 ? -14.267 -47.931 -14.616 1.00 59.00  ? 737  ARG A NE  1 
ATOM   3381 C  CZ  . ARG A 1 474 ? -13.800 -46.768 -14.140 1.00 56.56  ? 737  ARG A CZ  1 
ATOM   3382 N  NH1 . ARG A 1 474 ? -14.301 -45.629 -14.596 1.00 62.18  ? 737  ARG A NH1 1 
ATOM   3383 N  NH2 . ARG A 1 474 ? -12.825 -46.755 -13.240 1.00 47.67  ? 737  ARG A NH2 1 
ATOM   3384 N  N   . ALA A 1 475 ? -17.390 -52.303 -11.316 1.00 22.63  ? 738  ALA A N   1 
ATOM   3385 C  CA  . ALA A 1 475 ? -18.753 -52.905 -11.304 1.00 21.80  ? 738  ALA A CA  1 
ATOM   3386 C  C   . ALA A 1 475 ? -19.153 -53.276 -9.864  1.00 25.91  ? 738  ALA A C   1 
ATOM   3387 O  O   . ALA A 1 475 ? -20.371 -53.298 -9.572  1.00 25.53  ? 738  ALA A O   1 
ATOM   3388 C  CB  . ALA A 1 475 ? -18.773 -54.077 -12.282 1.00 21.59  ? 738  ALA A CB  1 
ATOM   3389 N  N   . ARG A 1 476 ? -18.178 -53.401 -8.938  1.00 22.92  ? 739  ARG A N   1 
ATOM   3390 C  CA  . ARG A 1 476 ? -18.426 -53.762 -7.517  1.00 21.62  ? 739  ARG A CA  1 
ATOM   3391 C  C   . ARG A 1 476 ? -18.739 -52.530 -6.687  1.00 23.76  ? 739  ARG A C   1 
ATOM   3392 O  O   . ARG A 1 476 ? -19.035 -52.706 -5.490  1.00 25.76  ? 739  ARG A O   1 
ATOM   3393 C  CB  . ARG A 1 476 ? -17.265 -54.552 -6.911  1.00 21.82  ? 739  ARG A CB  1 
ATOM   3394 C  CG  . ARG A 1 476 ? -17.223 -55.945 -7.504  1.00 22.61  ? 739  ARG A CG  1 
ATOM   3395 C  CD  . ARG A 1 476 ? -15.941 -56.771 -7.309  1.00 25.06  ? 739  ARG A CD  1 
ATOM   3396 N  NE  . ARG A 1 476 ? -15.554 -56.972 -5.952  1.00 24.95  ? 739  ARG A NE  1 
ATOM   3397 C  CZ  . ARG A 1 476 ? -15.168 -58.110 -5.413  1.00 23.06  ? 739  ARG A CZ  1 
ATOM   3398 N  NH1 . ARG A 1 476 ? -15.340 -59.266 -5.986  1.00 23.21  ? 739  ARG A NH1 1 
ATOM   3399 N  NH2 . ARG A 1 476 ? -14.662 -58.084 -4.212  1.00 23.09  ? 739  ARG A NH2 1 
ATOM   3400 N  N   . ILE A 1 477 ? -18.788 -51.361 -7.300  1.00 23.70  ? 740  ILE A N   1 
ATOM   3401 C  CA  . ILE A 1 477 ? -19.007 -50.101 -6.554  1.00 30.56  ? 740  ILE A CA  1 
ATOM   3402 C  C   . ILE A 1 477 ? -20.305 -49.437 -6.985  1.00 34.37  ? 740  ILE A C   1 
ATOM   3403 O  O   . ILE A 1 477 ? -20.648 -49.469 -8.185  1.00 30.36  ? 740  ILE A O   1 
ATOM   3404 C  CB  . ILE A 1 477 ? -17.827 -49.126 -6.741  1.00 30.51  ? 740  ILE A CB  1 
ATOM   3405 C  CG1 . ILE A 1 477 ? -16.545 -49.636 -6.076  1.00 34.10  ? 740  ILE A CG1 1 
ATOM   3406 C  CG2 . ILE A 1 477 ? -18.188 -47.749 -6.239  1.00 37.05  ? 740  ILE A CG2 1 
ATOM   3407 C  CD1 . ILE A 1 477 ? -15.334 -48.809 -6.459  1.00 36.54  ? 740  ILE A CD1 1 
ATOM   3408 N  N   A SER A 1 478 ? -20.983 -48.866 -5.990  0.25 35.59  ? 741  SER A N   1 
ATOM   3409 N  N   B SER A 1 478 ? -21.026 -48.854 -6.017  0.25 36.92  ? 741  SER A N   1 
ATOM   3410 C  CA  A SER A 1 478 ? -22.170 -47.981 -6.109  0.25 39.04  ? 741  SER A CA  1 
ATOM   3411 C  CA  B SER A 1 478 ? -22.232 -47.995 -6.224  0.25 40.98  ? 741  SER A CA  1 
ATOM   3412 C  C   A SER A 1 478 ? -21.834 -46.624 -5.475  0.25 39.00  ? 741  SER A C   1 
ATOM   3413 C  C   B SER A 1 478 ? -22.150 -46.744 -5.336  0.25 41.09  ? 741  SER A C   1 
ATOM   3414 O  O   A SER A 1 478 ? -20.889 -46.547 -4.651  0.25 37.10  ? 741  SER A O   1 
ATOM   3415 O  O   B SER A 1 478 ? -21.728 -46.868 -4.169  0.25 43.29  ? 741  SER A O   1 
ATOM   3416 C  CB  A SER A 1 478 ? -23.358 -48.643 -5.450  0.25 39.34  ? 741  SER A CB  1 
ATOM   3417 C  CB  B SER A 1 478 ? -23.514 -48.771 -5.980  0.25 41.47  ? 741  SER A CB  1 
ATOM   3418 O  OG  A SER A 1 478 ? -24.528 -47.860 -5.570  0.25 37.41  ? 741  SER A OG  1 
ATOM   3419 O  OG  B SER A 1 478 ? -23.539 -49.375 -4.689  0.25 42.14  ? 741  SER A OG  1 
ATOM   3420 N  N   . GLN A 1 479 ? -22.543 -45.569 -5.859  0.34 42.35  ? 742  GLN A N   1 
ATOM   3421 C  CA  . GLN A 1 479 ? -22.466 -44.265 -5.153  0.34 45.04  ? 742  GLN A CA  1 
ATOM   3422 C  C   . GLN A 1 479 ? -23.878 -43.864 -4.723  0.34 46.98  ? 742  GLN A C   1 
ATOM   3423 O  O   . GLN A 1 479 ? -24.820 -44.070 -5.517  0.34 44.33  ? 742  GLN A O   1 
ATOM   3424 C  CB  . GLN A 1 479 ? -21.830 -43.187 -6.032  0.34 47.19  ? 742  GLN A CB  1 
ATOM   3425 C  CG  . GLN A 1 479 ? -20.336 -43.383 -6.253  0.34 48.45  ? 742  GLN A CG  1 
ATOM   3426 C  CD  . GLN A 1 479 ? -19.539 -43.345 -4.971  0.34 47.67  ? 742  GLN A CD  1 
ATOM   3427 O  OE1 . GLN A 1 479 ? -19.643 -42.412 -4.179  0.34 45.53  ? 742  GLN A OE1 1 
ATOM   3428 N  NE2 . GLN A 1 479 ? -18.724 -44.368 -4.764  0.34 48.04  ? 742  GLN A NE2 1 
ATOM   3429 N  N   . GLY A 1 480 ? -23.994 -43.317 -3.510  1.00 48.07  ? 743  GLY A N   1 
ATOM   3430 C  CA  . GLY A 1 480 ? -25.277 -42.838 -2.945  1.00 50.55  ? 743  GLY A CA  1 
ATOM   3431 C  C   . GLY A 1 480 ? -25.959 -43.797 -1.983  1.00 51.22  ? 743  GLY A C   1 
ATOM   3432 O  O   . GLY A 1 480 ? -25.615 -44.983 -1.925  1.00 48.86  ? 743  GLY A O   1 
ATOM   3433 N  N   . ALA A 1 481 ? -26.929 -43.257 -1.242  1.00 52.12  ? 744  ALA A N   1 
ATOM   3434 C  CA  . ALA A 1 481 ? -27.692 -43.946 -0.187  1.00 47.73  ? 744  ALA A CA  1 
ATOM   3435 C  C   . ALA A 1 481 ? -29.047 -44.430 -0.725  1.00 42.20  ? 744  ALA A C   1 
ATOM   3436 O  O   . ALA A 1 481 ? -29.464 -44.012 -1.823  1.00 41.34  ? 744  ALA A O   1 
ATOM   3437 C  CB  . ALA A 1 481 ? -27.867 -43.004 0.991   1.00 48.81  ? 744  ALA A CB  1 
ATOM   3438 N  N   . GLY A 1 482 ? -29.683 -45.304 0.053   1.00 38.90  ? 745  GLY A N   1 
ATOM   3439 C  CA  . GLY A 1 482 ? -31.087 -45.718 -0.074  1.00 38.85  ? 745  GLY A CA  1 
ATOM   3440 C  C   . GLY A 1 482 ? -31.261 -46.735 -1.169  1.00 40.11  ? 745  GLY A C   1 
ATOM   3441 O  O   . GLY A 1 482 ? -32.371 -46.772 -1.737  1.00 40.24  ? 745  GLY A O   1 
ATOM   3442 N  N   . TRP A 1 483 ? -30.216 -47.502 -1.537  1.00 32.52  ? 746  TRP A N   1 
ATOM   3443 C  CA  . TRP A 1 483 ? -30.437 -48.508 -2.612  1.00 31.30  ? 746  TRP A CA  1 
ATOM   3444 C  C   . TRP A 1 483 ? -31.216 -49.717 -2.063  1.00 29.56  ? 746  TRP A C   1 
ATOM   3445 O  O   . TRP A 1 483 ? -30.758 -50.398 -1.141  1.00 29.09  ? 746  TRP A O   1 
ATOM   3446 C  CB  . TRP A 1 483 ? -29.117 -48.940 -3.225  1.00 34.08  ? 746  TRP A CB  1 
ATOM   3447 C  CG  . TRP A 1 483 ? -28.387 -47.917 -4.031  1.00 37.88  ? 746  TRP A CG  1 
ATOM   3448 C  CD1 . TRP A 1 483 ? -27.613 -46.901 -3.525  1.00 45.95  ? 746  TRP A CD1 1 
ATOM   3449 C  CD2 . TRP A 1 483 ? -28.185 -47.903 -5.449  1.00 37.67  ? 746  TRP A CD2 1 
ATOM   3450 N  NE1 . TRP A 1 483 ? -27.027 -46.190 -4.536  1.00 48.56  ? 746  TRP A NE1 1 
ATOM   3451 C  CE2 . TRP A 1 483 ? -27.347 -46.790 -5.730  1.00 46.88  ? 746  TRP A CE2 1 
ATOM   3452 C  CE3 . TRP A 1 483 ? -28.639 -48.691 -6.510  1.00 35.54  ? 746  TRP A CE3 1 
ATOM   3453 C  CZ2 . TRP A 1 483 ? -26.960 -46.466 -7.027  1.00 42.94  ? 746  TRP A CZ2 1 
ATOM   3454 C  CZ3 . TRP A 1 483 ? -28.270 -48.364 -7.789  1.00 35.86  ? 746  TRP A CZ3 1 
ATOM   3455 C  CH2 . TRP A 1 483 ? -27.483 -47.240 -8.042  1.00 40.33  ? 746  TRP A CH2 1 
ATOM   3456 N  N   . SER A 1 484 ? -32.348 -50.051 -2.675  1.00 25.92  ? 747  SER A N   1 
ATOM   3457 C  CA  . SER A 1 484 ? -33.036 -51.319 -2.390  1.00 26.01  ? 747  SER A CA  1 
ATOM   3458 C  C   . SER A 1 484 ? -32.177 -52.471 -2.912  1.00 22.01  ? 747  SER A C   1 
ATOM   3459 O  O   . SER A 1 484 ? -31.270 -52.204 -3.733  1.00 25.65  ? 747  SER A O   1 
ATOM   3460 C  CB  . SER A 1 484 ? -34.430 -51.369 -2.994  1.00 26.53  ? 747  SER A CB  1 
ATOM   3461 O  OG  . SER A 1 484 ? -34.361 -51.307 -4.408  1.00 26.87  ? 747  SER A OG  1 
ATOM   3462 N  N   . LEU A 1 485 ? -32.536 -53.706 -2.567  1.00 23.78  ? 748  LEU A N   1 
ATOM   3463 C  CA  . LEU A 1 485 ? -31.909 -54.898 -3.184  1.00 25.43  ? 748  LEU A CA  1 
ATOM   3464 C  C   . LEU A 1 485 ? -32.224 -54.964 -4.696  1.00 28.34  ? 748  LEU A C   1 
ATOM   3465 O  O   . LEU A 1 485 ? -31.305 -55.230 -5.533  1.00 24.54  ? 748  LEU A O   1 
ATOM   3466 C  CB  . LEU A 1 485 ? -32.333 -56.167 -2.477  1.00 25.03  ? 748  LEU A CB  1 
ATOM   3467 C  CG  . LEU A 1 485 ? -31.750 -57.446 -3.064  1.00 29.47  ? 748  LEU A CG  1 
ATOM   3468 C  CD1 . LEU A 1 485 ? -30.221 -57.366 -3.147  1.00 29.02  ? 748  LEU A CD1 1 
ATOM   3469 C  CD2 . LEU A 1 485 ? -32.188 -58.662 -2.261  1.00 26.91  ? 748  LEU A CD2 1 
ATOM   3470 N  N   . ARG A 1 486 ? -33.466 -54.594 -5.076  1.00 28.66  ? 749  ARG A N   1 
ATOM   3471 C  CA  . ARG A 1 486 ? -33.850 -54.580 -6.496  1.00 25.55  ? 749  ARG A CA  1 
ATOM   3472 C  C   . ARG A 1 486 ? -32.993 -53.555 -7.232  1.00 22.31  ? 749  ARG A C   1 
ATOM   3473 O  O   . ARG A 1 486 ? -32.540 -53.854 -8.318  1.00 25.22  ? 749  ARG A O   1 
ATOM   3474 C  CB  . ARG A 1 486 ? -35.326 -54.205 -6.669  1.00 27.55  ? 749  ARG A CB  1 
ATOM   3475 C  CG  . ARG A 1 486 ? -35.727 -53.999 -8.128  1.00 27.88  ? 749  ARG A CG  1 
ATOM   3476 C  CD  . ARG A 1 486 ? -37.242 -54.079 -8.138  1.00 30.93  ? 749  ARG A CD  1 
ATOM   3477 N  NE  . ARG A 1 486 ? -37.796 -53.922 -9.485  1.00 27.55  ? 749  ARG A NE  1 
ATOM   3478 C  CZ  . ARG A 1 486 ? -38.946 -54.480 -9.854  1.00 27.79  ? 749  ARG A CZ  1 
ATOM   3479 N  NH1 . ARG A 1 486 ? -39.609 -55.245 -8.991  1.00 29.08  ? 749  ARG A NH1 1 
ATOM   3480 N  NH2 . ARG A 1 486 ? -39.370 -54.351 -11.104 1.00 28.97  ? 749  ARG A NH2 1 
ATOM   3481 N  N   . GLU A 1 487 ? -32.826 -52.350 -6.706  1.00 23.99  ? 750  GLU A N   1 
ATOM   3482 C  CA  . GLU A 1 487 ? -32.096 -51.323 -7.483  1.00 25.72  ? 750  GLU A CA  1 
ATOM   3483 C  C   . GLU A 1 487 ? -30.609 -51.758 -7.610  1.00 25.36  ? 750  GLU A C   1 
ATOM   3484 O  O   . GLU A 1 487 ? -29.953 -51.490 -8.671  1.00 21.73  ? 750  GLU A O   1 
ATOM   3485 C  CB  . GLU A 1 487 ? -32.187 -49.972 -6.805  1.00 30.09  ? 750  GLU A CB  1 
ATOM   3486 C  CG  . GLU A 1 487 ? -31.833 -48.826 -7.756  1.00 39.82  ? 750  GLU A CG  1 
ATOM   3487 C  CD  . GLU A 1 487 ? -31.743 -47.413 -7.183  1.00 46.33  ? 750  GLU A CD  1 
ATOM   3488 O  OE1 . GLU A 1 487 ? -32.017 -47.241 -5.962  1.00 53.74  ? 750  GLU A OE1 1 
ATOM   3489 O  OE2 . GLU A 1 487 ? -31.431 -46.473 -7.973  1.00 43.14  ? 750  GLU A OE2 1 
ATOM   3490 N  N   . THR A 1 488 ? -30.062 -52.357 -6.530  1.00 25.49  ? 751  THR A N   1 
ATOM   3491 C  CA  . THR A 1 488 ? -28.650 -52.840 -6.525  1.00 22.87  ? 751  THR A CA  1 
ATOM   3492 C  C   . THR A 1 488 ? -28.529 -53.917 -7.603  1.00 22.39  ? 751  THR A C   1 
ATOM   3493 O  O   . THR A 1 488 ? -27.537 -53.884 -8.421  1.00 22.55  ? 751  THR A O   1 
ATOM   3494 C  CB  . THR A 1 488 ? -28.286 -53.381 -5.165  1.00 22.26  ? 751  THR A CB  1 
ATOM   3495 O  OG1 . THR A 1 488 ? -28.534 -52.377 -4.179  1.00 24.28  ? 751  THR A OG1 1 
ATOM   3496 C  CG2 . THR A 1 488 ? -26.846 -53.833 -5.138  1.00 22.52  ? 751  THR A CG2 1 
ATOM   3497 N  N   . ALA A 1 489 ? -29.477 -54.870 -7.632  1.00 22.02  ? 752  ALA A N   1 
ATOM   3498 C  CA  . ALA A 1 489 ? -29.530 -55.908 -8.692  1.00 22.06  ? 752  ALA A CA  1 
ATOM   3499 C  C   . ALA A 1 489 ? -29.589 -55.300 -10.092 1.00 25.13  ? 752  ALA A C   1 
ATOM   3500 O  O   . ALA A 1 489 ? -28.873 -55.810 -11.032 1.00 24.24  ? 752  ALA A O   1 
ATOM   3501 C  CB  . ALA A 1 489 ? -30.684 -56.832 -8.476  1.00 23.36  ? 752  ALA A CB  1 
ATOM   3502 N  N   . CYS A 1 490 ? -30.434 -54.288 -10.281 1.00 23.53  ? 753  CYS A N   1 
ATOM   3503 C  CA  . CYS A 1 490 ? -30.610 -53.667 -11.619 1.00 21.32  ? 753  CYS A CA  1 
ATOM   3504 C  C   . CYS A 1 490 ? -29.306 -52.935 -12.023 1.00 24.17  ? 753  CYS A C   1 
ATOM   3505 O  O   . CYS A 1 490 ? -28.973 -52.908 -13.206 1.00 23.71  ? 753  CYS A O   1 
ATOM   3506 C  CB  . CYS A 1 490 ? -31.823 -52.738 -11.617 1.00 24.21  ? 753  CYS A CB  1 
ATOM   3507 S  SG  . CYS A 1 490 ? -33.361 -53.698 -11.582 1.00 28.24  ? 753  CYS A SG  1 
ATOM   3508 N  N   . LEU A 1 491 ? -28.575 -52.321 -11.100 1.00 21.87  ? 754  LEU A N   1 
ATOM   3509 C  CA  . LEU A 1 491 ? -27.244 -51.720 -11.417 1.00 21.55  ? 754  LEU A CA  1 
ATOM   3510 C  C   . LEU A 1 491 ? -26.224 -52.811 -11.779 1.00 23.22  ? 754  LEU A C   1 
ATOM   3511 O  O   . LEU A 1 491 ? -25.499 -52.655 -12.741 1.00 23.48  ? 754  LEU A O   1 
ATOM   3512 C  CB  . LEU A 1 491 ? -26.744 -50.889 -10.225 1.00 23.49  ? 754  LEU A CB  1 
ATOM   3513 C  CG  . LEU A 1 491 ? -25.386 -50.227 -10.429 1.00 23.96  ? 754  LEU A CG  1 
ATOM   3514 C  CD1 . LEU A 1 491 ? -25.421 -49.300 -11.652 1.00 26.47  ? 754  LEU A CD1 1 
ATOM   3515 C  CD2 . LEU A 1 491 ? -24.920 -49.509 -9.158  1.00 28.25  ? 754  LEU A CD2 1 
ATOM   3516 N  N   . GLY A 1 492 ? -26.236 -53.947 -11.085 1.00 23.01  ? 755  GLY A N   1 
ATOM   3517 C  CA  . GLY A 1 492 ? -25.415 -55.097 -11.479 1.00 21.77  ? 755  GLY A CA  1 
ATOM   3518 C  C   . GLY A 1 492 ? -25.677 -55.585 -12.871 1.00 21.69  ? 755  GLY A C   1 
ATOM   3519 O  O   . GLY A 1 492 ? -24.712 -55.887 -13.648 1.00 22.44  ? 755  GLY A O   1 
ATOM   3520 N  N   . LYS A 1 493 ? -26.948 -55.653 -13.217 1.00 21.56  ? 756  LYS A N   1 
ATOM   3521 C  CA  . LYS A 1 493 ? -27.385 -56.018 -14.589 1.00 21.16  ? 756  LYS A CA  1 
ATOM   3522 C  C   . LYS A 1 493 ? -26.908 -55.002 -15.619 1.00 20.45  ? 756  LYS A C   1 
ATOM   3523 O  O   . LYS A 1 493 ? -26.536 -55.472 -16.684 1.00 20.31  ? 756  LYS A O   1 
ATOM   3524 C  CB  . LYS A 1 493 ? -28.911 -56.192 -14.642 1.00 23.25  ? 756  LYS A CB  1 
ATOM   3525 C  CG  . LYS A 1 493 ? -29.416 -56.692 -15.986 1.00 25.89  ? 756  LYS A CG  1 
ATOM   3526 C  CD  . LYS A 1 493 ? -30.882 -57.112 -15.870 1.00 26.42  ? 756  LYS A CD  1 
ATOM   3527 C  CE  . LYS A 1 493 ? -31.435 -57.644 -17.179 1.00 26.93  ? 756  LYS A CE  1 
ATOM   3528 N  NZ  . LYS A 1 493 ? -32.855 -58.054 -16.992 1.00 29.51  ? 756  LYS A NZ  1 
ATOM   3529 N  N   . SER A 1 494 ? -26.894 -53.699 -15.365 1.00 21.20  ? 757  SER A N   1 
ATOM   3530 C  CA  . SER A 1 494 ? -26.305 -52.718 -16.300 1.00 26.20  ? 757  SER A CA  1 
ATOM   3531 C  C   . SER A 1 494 ? -24.855 -53.102 -16.610 1.00 22.51  ? 757  SER A C   1 
ATOM   3532 O  O   . SER A 1 494 ? -24.498 -53.081 -17.817 1.00 20.90  ? 757  SER A O   1 
ATOM   3533 C  CB  . SER A 1 494 ? -26.335 -51.305 -15.801 1.00 28.50  ? 757  SER A CB  1 
ATOM   3534 O  OG  . SER A 1 494 ? -27.656 -50.860 -15.612 1.00 38.92  ? 757  SER A OG  1 
ATOM   3535 N  N   . TYR A 1 495 ? -24.034 -53.306 -15.577 1.00 21.56  ? 758  TYR A N   1 
ATOM   3536 C  CA  . TYR A 1 495 ? -22.607 -53.671 -15.783 1.00 21.49  ? 758  TYR A CA  1 
ATOM   3537 C  C   . TYR A 1 495 ? -22.501 -54.942 -16.613 1.00 20.28  ? 758  TYR A C   1 
ATOM   3538 O  O   . TYR A 1 495 ? -21.702 -55.019 -17.633 1.00 22.70  ? 758  TYR A O   1 
ATOM   3539 C  CB  . TYR A 1 495 ? -21.864 -53.787 -14.424 1.00 20.05  ? 758  TYR A CB  1 
ATOM   3540 C  CG  . TYR A 1 495 ? -21.395 -52.455 -13.907 1.00 19.92  ? 758  TYR A CG  1 
ATOM   3541 C  CD1 . TYR A 1 495 ? -20.260 -51.858 -14.458 1.00 21.09  ? 758  TYR A CD1 1 
ATOM   3542 C  CD2 . TYR A 1 495 ? -22.084 -51.774 -12.928 1.00 24.86  ? 758  TYR A CD2 1 
ATOM   3543 C  CE1 . TYR A 1 495 ? -19.863 -50.595 -14.077 1.00 22.48  ? 758  TYR A CE1 1 
ATOM   3544 C  CE2 . TYR A 1 495 ? -21.636 -50.540 -12.452 1.00 24.53  ? 758  TYR A CE2 1 
ATOM   3545 C  CZ  . TYR A 1 495 ? -20.521 -49.955 -13.041 1.00 26.76  ? 758  TYR A CZ  1 
ATOM   3546 O  OH  . TYR A 1 495 ? -20.089 -48.705 -12.681 1.00 30.79  ? 758  TYR A OH  1 
ATOM   3547 N  N   . ALA A 1 496 ? -23.286 -55.958 -16.248 1.00 19.33  ? 759  ALA A N   1 
ATOM   3548 C  CA  . ALA A 1 496 ? -23.304 -57.249 -16.947 1.00 19.52  ? 759  ALA A CA  1 
ATOM   3549 C  C   . ALA A 1 496 ? -23.603 -57.058 -18.417 1.00 20.27  ? 759  ALA A C   1 
ATOM   3550 O  O   . ALA A 1 496 ? -22.909 -57.627 -19.256 1.00 20.15  ? 759  ALA A O   1 
ATOM   3551 C  CB  . ALA A 1 496 ? -24.277 -58.175 -16.274 1.00 21.77  ? 759  ALA A CB  1 
ATOM   3552 N  N   . GLN A 1 497 ? -24.651 -56.302 -18.742 1.00 22.94  ? 760  GLN A N   1 
ATOM   3553 C  CA  . GLN A 1 497 ? -24.971 -56.108 -20.182 1.00 23.78  ? 760  GLN A CA  1 
ATOM   3554 C  C   . GLN A 1 497 ? -23.859 -55.313 -20.917 1.00 22.96  ? 760  GLN A C   1 
ATOM   3555 O  O   . GLN A 1 497 ? -23.553 -55.660 -22.129 1.00 21.80  ? 760  GLN A O   1 
ATOM   3556 C  CB  . GLN A 1 497 ? -26.386 -55.525 -20.306 1.00 23.53  ? 760  GLN A CB  1 
ATOM   3557 C  CG  . GLN A 1 497 ? -27.386 -56.565 -19.788 1.00 27.59  ? 760  GLN A CG  1 
ATOM   3558 C  CD  . GLN A 1 497 ? -28.854 -56.353 -20.125 1.00 31.64  ? 760  GLN A CD  1 
ATOM   3559 O  OE1 . GLN A 1 497 ? -29.660 -57.299 -20.072 1.00 31.05  ? 760  GLN A OE1 1 
ATOM   3560 N  NE2 . GLN A 1 497 ? -29.177 -55.133 -20.480 1.00 27.47  ? 760  GLN A NE2 1 
ATOM   3561 N  N   . MET A 1 498 ? -23.263 -54.319 -20.261 1.00 21.17  ? 761  MET A N   1 
ATOM   3562 C  CA  . MET A 1 498 ? -22.140 -53.575 -20.872 1.00 24.43  ? 761  MET A CA  1 
ATOM   3563 C  C   . MET A 1 498 ? -21.039 -54.561 -21.185 1.00 21.84  ? 761  MET A C   1 
ATOM   3564 O  O   . MET A 1 498 ? -20.486 -54.539 -22.289 1.00 23.62  ? 761  MET A O   1 
ATOM   3565 C  CB  . MET A 1 498 ? -21.649 -52.452 -19.972 1.00 24.30  ? 761  MET A CB  1 
ATOM   3566 C  CG  . MET A 1 498 ? -20.353 -51.752 -20.487 1.00 25.74  ? 761  MET A CG  1 
ATOM   3567 S  SD  . MET A 1 498 ? -19.833 -50.489 -19.325 1.00 32.51  ? 761  MET A SD  1 
ATOM   3568 C  CE  . MET A 1 498 ? -19.022 -51.516 -18.103 1.00 28.35  ? 761  MET A CE  1 
ATOM   3569 N  N   . TRP A 1 499 ? -20.730 -55.447 -20.247 1.00 20.48  ? 762  TRP A N   1 
ATOM   3570 C  CA  . TRP A 1 499 ? -19.658 -56.446 -20.464 1.00 20.82  ? 762  TRP A CA  1 
ATOM   3571 C  C   . TRP A 1 499 ? -19.991 -57.342 -21.683 1.00 23.48  ? 762  TRP A C   1 
ATOM   3572 O  O   . TRP A 1 499 ? -19.111 -57.615 -22.476 1.00 19.67  ? 762  TRP A O   1 
ATOM   3573 C  CB  . TRP A 1 499 ? -19.395 -57.258 -19.193 1.00 20.24  ? 762  TRP A CB  1 
ATOM   3574 C  CG  . TRP A 1 499 ? -18.795 -56.526 -18.030 1.00 20.81  ? 762  TRP A CG  1 
ATOM   3575 C  CD1 . TRP A 1 499 ? -18.295 -55.268 -17.972 1.00 21.61  ? 762  TRP A CD1 1 
ATOM   3576 C  CD2 . TRP A 1 499 ? -18.616 -57.069 -16.710 1.00 19.59  ? 762  TRP A CD2 1 
ATOM   3577 N  NE1 . TRP A 1 499 ? -17.852 -54.993 -16.704 1.00 22.70  ? 762  TRP A NE1 1 
ATOM   3578 C  CE2 . TRP A 1 499 ? -17.993 -56.098 -15.935 1.00 20.71  ? 762  TRP A CE2 1 
ATOM   3579 C  CE3 . TRP A 1 499 ? -18.937 -58.286 -16.125 1.00 22.49  ? 762  TRP A CE3 1 
ATOM   3580 C  CZ2 . TRP A 1 499 ? -17.658 -56.293 -14.599 1.00 20.59  ? 762  TRP A CZ2 1 
ATOM   3581 C  CZ3 . TRP A 1 499 ? -18.608 -58.490 -14.813 1.00 23.43  ? 762  TRP A CZ3 1 
ATOM   3582 C  CH2 . TRP A 1 499 ? -18.058 -57.476 -14.057 1.00 21.48  ? 762  TRP A CH2 1 
ATOM   3583 N  N   A SER A 1 500 ? -21.255 -57.776 -21.818 0.25 23.33  ? 763  SER A N   1 
ATOM   3584 N  N   B SER A 1 500 ? -21.253 -57.802 -21.804 0.25 23.48  ? 763  SER A N   1 
ATOM   3585 C  CA  A SER A 1 500 ? -21.699 -58.668 -22.921 0.25 22.83  ? 763  SER A CA  1 
ATOM   3586 C  CA  B SER A 1 500 ? -21.699 -58.671 -22.927 0.25 23.03  ? 763  SER A CA  1 
ATOM   3587 C  C   A SER A 1 500 ? -21.515 -57.972 -24.272 0.25 22.38  ? 763  SER A C   1 
ATOM   3588 C  C   B SER A 1 500 ? -21.425 -57.954 -24.252 0.25 21.73  ? 763  SER A C   1 
ATOM   3589 O  O   A SER A 1 500 ? -21.178 -58.671 -25.265 0.25 25.21  ? 763  SER A O   1 
ATOM   3590 O  O   B SER A 1 500 ? -20.858 -58.597 -25.168 0.25 20.82  ? 763  SER A O   1 
ATOM   3591 C  CB  A SER A 1 500 ? -23.119 -59.136 -22.725 0.25 23.06  ? 763  SER A CB  1 
ATOM   3592 C  CB  B SER A 1 500 ? -23.153 -59.103 -22.814 0.25 23.94  ? 763  SER A CB  1 
ATOM   3593 O  OG  A SER A 1 500 ? -23.230 -59.788 -21.471 0.25 23.50  ? 763  SER A OG  1 
ATOM   3594 O  OG  B SER A 1 500 ? -24.031 -58.042 -23.156 0.25 27.20  ? 763  SER A OG  1 
ATOM   3595 N  N   . LEU A 1 501 ? -21.716 -56.647 -24.300 1.00 22.16  ? 764  LEU A N   1 
ATOM   3596 C  CA  . LEU A 1 501 ? -21.659 -55.888 -25.552 1.00 24.47  ? 764  LEU A CA  1 
ATOM   3597 C  C   . LEU A 1 501 ? -20.241 -55.399 -25.903 1.00 25.97  ? 764  LEU A C   1 
ATOM   3598 O  O   . LEU A 1 501 ? -19.896 -55.384 -27.110 1.00 27.98  ? 764  LEU A O   1 
ATOM   3599 C  CB  . LEU A 1 501 ? -22.648 -54.726 -25.441 1.00 26.95  ? 764  LEU A CB  1 
ATOM   3600 C  CG  . LEU A 1 501 ? -22.978 -54.116 -26.790 1.00 36.50  ? 764  LEU A CG  1 
ATOM   3601 C  CD1 . LEU A 1 501 ? -23.736 -55.144 -27.635 1.00 40.22  ? 764  LEU A CD1 1 
ATOM   3602 C  CD2 . LEU A 1 501 ? -23.792 -52.826 -26.609 1.00 38.09  ? 764  LEU A CD2 1 
ATOM   3603 N  N   . MET A 1 502 ? -19.439 -54.968 -24.919 1.00 23.81  ? 765  MET A N   1 
ATOM   3604 C  CA  . MET A 1 502 ? -18.171 -54.292 -25.149 1.00 22.71  ? 765  MET A CA  1 
ATOM   3605 C  C   . MET A 1 502 ? -17.024 -55.264 -24.848 1.00 22.02  ? 765  MET A C   1 
ATOM   3606 O  O   . MET A 1 502 ? -16.008 -55.112 -25.504 1.00 20.68  ? 765  MET A O   1 
ATOM   3607 C  CB  . MET A 1 502 ? -18.046 -53.050 -24.296 1.00 26.50  ? 765  MET A CB  1 
ATOM   3608 C  CG  . MET A 1 502 ? -19.159 -52.033 -24.499 1.00 27.48  ? 765  MET A CG  1 
ATOM   3609 S  SD  . MET A 1 502 ? -19.047 -51.342 -26.192 1.00 33.30  ? 765  MET A SD  1 
ATOM   3610 C  CE  . MET A 1 502 ? -20.194 -52.365 -27.062 1.00 41.24  ? 765  MET A CE  1 
ATOM   3611 N  N   . TYR A 1 503 ? -17.144 -56.121 -23.833 1.00 20.98  ? 766  TYR A N   1 
ATOM   3612 C  CA  . TYR A 1 503 ? -16.008 -56.931 -23.333 1.00 20.18  ? 766  TYR A CA  1 
ATOM   3613 C  C   . TYR A 1 503 ? -16.246 -58.435 -23.431 1.00 21.79  ? 766  TYR A C   1 
ATOM   3614 O  O   . TYR A 1 503 ? -15.634 -59.209 -22.628 1.00 19.75  ? 766  TYR A O   1 
ATOM   3615 C  CB  . TYR A 1 503 ? -15.693 -56.475 -21.920 1.00 22.98  ? 766  TYR A CB  1 
ATOM   3616 C  CG  . TYR A 1 503 ? -15.524 -54.990 -21.740 1.00 22.96  ? 766  TYR A CG  1 
ATOM   3617 C  CD1 . TYR A 1 503 ? -14.529 -54.277 -22.382 1.00 21.63  ? 766  TYR A CD1 1 
ATOM   3618 C  CD2 . TYR A 1 503 ? -16.317 -54.287 -20.860 1.00 26.40  ? 766  TYR A CD2 1 
ATOM   3619 C  CE1 . TYR A 1 503 ? -14.387 -52.916 -22.186 1.00 20.94  ? 766  TYR A CE1 1 
ATOM   3620 C  CE2 . TYR A 1 503 ? -16.187 -52.905 -20.651 1.00 25.74  ? 766  TYR A CE2 1 
ATOM   3621 C  CZ  . TYR A 1 503 ? -15.220 -52.212 -21.330 1.00 21.88  ? 766  TYR A CZ  1 
ATOM   3622 O  OH  . TYR A 1 503 ? -15.026 -50.887 -21.134 1.00 22.64  ? 766  TYR A OH  1 
ATOM   3623 N  N   . PHE A 1 504 ? -17.124 -58.853 -24.353 1.00 21.49  ? 767  PHE A N   1 
ATOM   3624 C  CA  . PHE A 1 504 ? -17.514 -60.268 -24.571 1.00 22.71  ? 767  PHE A CA  1 
ATOM   3625 C  C   . PHE A 1 504 ? -16.273 -61.129 -24.855 1.00 23.32  ? 767  PHE A C   1 
ATOM   3626 O  O   . PHE A 1 504 ? -16.290 -62.351 -24.726 1.00 21.75  ? 767  PHE A O   1 
ATOM   3627 C  CB  . PHE A 1 504 ? -18.421 -60.401 -25.821 1.00 22.75  ? 767  PHE A CB  1 
ATOM   3628 C  CG  . PHE A 1 504 ? -17.902 -59.672 -27.015 1.00 22.52  ? 767  PHE A CG  1 
ATOM   3629 C  CD1 . PHE A 1 504 ? -17.123 -60.323 -27.953 1.00 22.71  ? 767  PHE A CD1 1 
ATOM   3630 C  CD2 . PHE A 1 504 ? -18.288 -58.382 -27.257 1.00 22.53  ? 767  PHE A CD2 1 
ATOM   3631 C  CE1 . PHE A 1 504 ? -16.649 -59.633 -29.032 1.00 23.11  ? 767  PHE A CE1 1 
ATOM   3632 C  CE2 . PHE A 1 504 ? -17.779 -57.684 -28.319 1.00 24.06  ? 767  PHE A CE2 1 
ATOM   3633 C  CZ  . PHE A 1 504 ? -17.011 -58.330 -29.234 1.00 21.68  ? 767  PHE A CZ  1 
ATOM   3634 N  N   . HIS A 1 505 ? -15.225 -60.498 -25.385 1.00 23.93  ? 768  HIS A N   1 
ATOM   3635 C  CA  . HIS A 1 505 ? -13.934 -61.146 -25.754 1.00 23.54  ? 768  HIS A CA  1 
ATOM   3636 C  C   . HIS A 1 505 ? -13.028 -61.486 -24.563 1.00 20.77  ? 768  HIS A C   1 
ATOM   3637 O  O   . HIS A 1 505 ? -11.971 -62.126 -24.756 1.00 21.61  ? 768  HIS A O   1 
ATOM   3638 C  CB  . HIS A 1 505 ? -13.186 -60.272 -26.780 1.00 20.21  ? 768  HIS A CB  1 
ATOM   3639 C  CG  . HIS A 1 505 ? -13.034 -58.862 -26.372 1.00 21.29  ? 768  HIS A CG  1 
ATOM   3640 N  ND1 . HIS A 1 505 ? -11.984 -58.434 -25.630 1.00 20.25  ? 768  HIS A ND1 1 
ATOM   3641 C  CD2 . HIS A 1 505 ? -13.837 -57.792 -26.542 1.00 22.29  ? 768  HIS A CD2 1 
ATOM   3642 C  CE1 . HIS A 1 505 ? -12.159 -57.179 -25.324 1.00 19.39  ? 768  HIS A CE1 1 
ATOM   3643 N  NE2 . HIS A 1 505 ? -13.283 -56.732 -25.860 1.00 22.07  ? 768  HIS A NE2 1 
ATOM   3644 N  N   . ARG A 1 506 ? -13.412 -61.100 -23.340 1.00 18.62  ? 769  ARG A N   1 
ATOM   3645 C  CA  . ARG A 1 506 ? -12.695 -61.391 -22.097 1.00 19.69  ? 769  ARG A CA  1 
ATOM   3646 C  C   . ARG A 1 506 ? -13.459 -62.575 -21.460 1.00 21.01  ? 769  ARG A C   1 
ATOM   3647 O  O   . ARG A 1 506 ? -14.665 -62.399 -21.147 1.00 22.21  ? 769  ARG A O   1 
ATOM   3648 C  CB  . ARG A 1 506 ? -12.686 -60.143 -21.219 1.00 18.14  ? 769  ARG A CB  1 
ATOM   3649 C  CG  . ARG A 1 506 ? -12.164 -58.850 -21.803 1.00 20.26  ? 769  ARG A CG  1 
ATOM   3650 C  CD  . ARG A 1 506 ? -10.809 -59.030 -22.520 1.00 20.80  ? 769  ARG A CD  1 
ATOM   3651 N  NE  . ARG A 1 506 ? -9.845  -59.576 -21.558 1.00 20.35  ? 769  ARG A NE  1 
ATOM   3652 C  CZ  . ARG A 1 506 ? -9.301  -58.916 -20.559 1.00 21.46  ? 769  ARG A CZ  1 
ATOM   3653 N  NH1 . ARG A 1 506 ? -8.582  -59.588 -19.673 1.00 18.94  ? 769  ARG A NH1 1 
ATOM   3654 N  NH2 . ARG A 1 506 ? -9.472  -57.604 -20.403 1.00 19.38  ? 769  ARG A NH2 1 
ATOM   3655 N  N   . ARG A 1 507 ? -12.839 -63.755 -21.400 1.00 21.38  ? 770  ARG A N   1 
ATOM   3656 C  CA  . ARG A 1 507 ? -13.476 -64.994 -20.923 1.00 22.93  ? 770  ARG A CA  1 
ATOM   3657 C  C   . ARG A 1 507 ? -14.144 -64.773 -19.567 1.00 23.17  ? 770  ARG A C   1 
ATOM   3658 O  O   . ARG A 1 507 ? -15.325 -65.117 -19.477 1.00 24.38  ? 770  ARG A O   1 
ATOM   3659 C  CB  . ARG A 1 507 ? -12.472 -66.148 -20.855 1.00 22.92  ? 770  ARG A CB  1 
ATOM   3660 C  CG  . ARG A 1 507 ? -11.899 -66.591 -22.184 1.00 23.21  ? 770  ARG A CG  1 
ATOM   3661 C  CD  . ARG A 1 507 ? -10.676 -67.536 -21.988 1.00 24.76  ? 770  ARG A CD  1 
ATOM   3662 N  NE  . ARG A 1 507 ? -10.304 -68.021 -23.299 1.00 25.54  ? 770  ARG A NE  1 
ATOM   3663 C  CZ  . ARG A 1 507 ? -9.759  -67.279 -24.213 1.00 25.10  ? 770  ARG A CZ  1 
ATOM   3664 N  NH1 . ARG A 1 507 ? -9.350  -66.052 -23.931 1.00 24.02  ? 770  ARG A NH1 1 
ATOM   3665 N  NH2 . ARG A 1 507 ? -9.557  -67.788 -25.406 1.00 26.58  ? 770  ARG A NH2 1 
ATOM   3666 N  N   . ASP A 1 508 ? -13.491 -64.142 -18.589 1.00 20.18  ? 771  ASP A N   1 
ATOM   3667 C  CA  . ASP A 1 508 ? -14.023 -63.988 -17.224 1.00 21.01  ? 771  ASP A CA  1 
ATOM   3668 C  C   . ASP A 1 508 ? -15.253 -63.055 -17.241 1.00 23.40  ? 771  ASP A C   1 
ATOM   3669 O  O   . ASP A 1 508 ? -16.206 -63.272 -16.423 1.00 21.69  ? 771  ASP A O   1 
ATOM   3670 C  CB  . ASP A 1 508 ? -12.965 -63.389 -16.288 1.00 20.50  ? 771  ASP A CB  1 
ATOM   3671 C  CG  . ASP A 1 508 ? -11.754 -64.296 -16.035 1.00 22.03  ? 771  ASP A CG  1 
ATOM   3672 O  OD1 . ASP A 1 508 ? -11.754 -65.452 -16.514 1.00 21.12  ? 771  ASP A OD1 1 
ATOM   3673 O  OD2 . ASP A 1 508 ? -10.777 -63.784 -15.491 1.00 20.40  ? 771  ASP A OD2 1 
ATOM   3674 N  N   . LEU A 1 509 ? -15.254 -62.037 -18.124 1.00 20.38  ? 772  LEU A N   1 
ATOM   3675 C  CA  . LEU A 1 509 ? -16.351 -61.045 -18.107 1.00 22.68  ? 772  LEU A CA  1 
ATOM   3676 C  C   . LEU A 1 509 ? -17.560 -61.631 -18.820 1.00 21.49  ? 772  LEU A C   1 
ATOM   3677 O  O   . LEU A 1 509 ? -18.698 -61.360 -18.350 1.00 21.93  ? 772  LEU A O   1 
ATOM   3678 C  CB  . LEU A 1 509 ? -15.897 -59.711 -18.696 1.00 22.95  ? 772  LEU A CB  1 
ATOM   3679 C  CG  . LEU A 1 509 ? -14.756 -59.017 -17.938 1.00 21.50  ? 772  LEU A CG  1 
ATOM   3680 C  CD1 . LEU A 1 509 ? -14.561 -57.601 -18.481 1.00 23.87  ? 772  LEU A CD1 1 
ATOM   3681 C  CD2 . LEU A 1 509 ? -14.976 -58.944 -16.419 1.00 22.42  ? 772  LEU A CD2 1 
ATOM   3682 N  N   . ARG A 1 510 ? -17.359 -62.468 -19.822 1.00 21.54  ? 773  ARG A N   1 
ATOM   3683 C  CA  . ARG A 1 510 ? -18.526 -63.051 -20.520 1.00 23.22  ? 773  ARG A CA  1 
ATOM   3684 C  C   . ARG A 1 510 ? -19.186 -64.013 -19.531 1.00 25.67  ? 773  ARG A C   1 
ATOM   3685 O  O   . ARG A 1 510 ? -20.408 -63.999 -19.453 1.00 24.37  ? 773  ARG A O   1 
ATOM   3686 C  CB  . ARG A 1 510 ? -18.167 -63.688 -21.860 1.00 21.13  ? 773  ARG A CB  1 
ATOM   3687 C  CG  . ARG A 1 510 ? -19.426 -64.044 -22.639 1.00 24.66  ? 773  ARG A CG  1 
ATOM   3688 C  CD  . ARG A 1 510 ? -19.201 -64.922 -23.855 1.00 24.42  ? 773  ARG A CD  1 
ATOM   3689 N  NE  . ARG A 1 510 ? -18.269 -64.340 -24.789 1.00 22.62  ? 773  ARG A NE  1 
ATOM   3690 C  CZ  . ARG A 1 510 ? -18.132 -64.780 -26.037 1.00 23.38  ? 773  ARG A CZ  1 
ATOM   3691 N  NH1 . ARG A 1 510 ? -18.929 -65.745 -26.508 1.00 23.18  ? 773  ARG A NH1 1 
ATOM   3692 N  NH2 . ARG A 1 510 ? -17.246 -64.252 -26.847 1.00 26.04  ? 773  ARG A NH2 1 
ATOM   3693 N  N   . LEU A 1 511 ? -18.401 -64.788 -18.754 1.00 23.54  ? 774  LEU A N   1 
ATOM   3694 C  CA  . LEU A 1 511 ? -18.957 -65.757 -17.781 1.00 24.11  ? 774  LEU A CA  1 
ATOM   3695 C  C   . LEU A 1 511 ? -19.659 -64.965 -16.666 1.00 21.61  ? 774  LEU A C   1 
ATOM   3696 O  O   . LEU A 1 511 ? -20.800 -65.320 -16.289 1.00 20.72  ? 774  LEU A O   1 
ATOM   3697 C  CB  . LEU A 1 511 ? -17.827 -66.634 -17.207 1.00 23.64  ? 774  LEU A CB  1 
ATOM   3698 C  CG  . LEU A 1 511 ? -18.254 -67.941 -16.548 1.00 25.61  ? 774  LEU A CG  1 
ATOM   3699 C  CD1 . LEU A 1 511 ? -17.107 -68.930 -16.484 1.00 26.64  ? 774  LEU A CD1 1 
ATOM   3700 C  CD2 . LEU A 1 511 ? -18.768 -67.704 -15.141 1.00 24.67  ? 774  LEU A CD2 1 
ATOM   3701 N  N   . ALA A 1 512 ? -19.020 -63.946 -16.129 1.00 20.54  ? 775  ALA A N   1 
ATOM   3702 C  CA  . ALA A 1 512 ? -19.545 -63.210 -14.971 1.00 21.85  ? 775  ALA A CA  1 
ATOM   3703 C  C   . ALA A 1 512 ? -20.850 -62.471 -15.399 1.00 22.77  ? 775  ALA A C   1 
ATOM   3704 O  O   . ALA A 1 512 ? -21.789 -62.414 -14.615 1.00 21.68  ? 775  ALA A O   1 
ATOM   3705 C  CB  . ALA A 1 512 ? -18.550 -62.256 -14.398 1.00 21.55  ? 775  ALA A CB  1 
ATOM   3706 N  N   . ALA A 1 513 ? -20.898 -61.953 -16.611 1.00 21.33  ? 776  ALA A N   1 
ATOM   3707 C  CA  . ALA A 1 513 ? -22.081 -61.274 -17.212 1.00 21.25  ? 776  ALA A CA  1 
ATOM   3708 C  C   . ALA A 1 513 ? -23.236 -62.253 -17.325 1.00 23.73  ? 776  ALA A C   1 
ATOM   3709 O  O   . ALA A 1 513 ? -24.375 -61.901 -16.884 1.00 22.49  ? 776  ALA A O   1 
ATOM   3710 C  CB  . ALA A 1 513 ? -21.757 -60.670 -18.571 1.00 20.56  ? 776  ALA A CB  1 
ATOM   3711 N  N   . ASN A 1 514 ? -22.941 -63.431 -17.866 1.00 20.39  ? 777  ASN A N   1 
ATOM   3712 C  CA  . ASN A 1 514 ? -23.960 -64.505 -17.970 1.00 23.88  ? 777  ASN A CA  1 
ATOM   3713 C  C   . ASN A 1 514 ? -24.460 -64.867 -16.580 1.00 22.78  ? 777  ASN A C   1 
ATOM   3714 O  O   . ASN A 1 514 ? -25.712 -64.992 -16.404 1.00 23.28  ? 777  ASN A O   1 
ATOM   3715 C  CB  . ASN A 1 514 ? -23.447 -65.703 -18.717 1.00 22.74  ? 777  ASN A CB  1 
ATOM   3716 C  CG  . ASN A 1 514 ? -23.409 -65.421 -20.206 1.00 26.99  ? 777  ASN A CG  1 
ATOM   3717 O  OD1 . ASN A 1 514 ? -24.225 -64.666 -20.722 1.00 30.51  ? 777  ASN A OD1 1 
ATOM   3718 N  ND2 . ASN A 1 514 ? -22.459 -66.045 -20.892 1.00 30.30  ? 777  ASN A ND2 1 
ATOM   3719 N  N   . ALA A 1 515 ? -23.577 -64.998 -15.598 1.00 22.80  ? 778  ALA A N   1 
ATOM   3720 C  CA  . ALA A 1 515 ? -23.980 -65.307 -14.211 1.00 23.12  ? 778  ALA A CA  1 
ATOM   3721 C  C   . ALA A 1 515 ? -24.893 -64.201 -13.645 1.00 24.58  ? 778  ALA A C   1 
ATOM   3722 O  O   . ALA A 1 515 ? -25.913 -64.525 -13.004 1.00 24.57  ? 778  ALA A O   1 
ATOM   3723 C  CB  . ALA A 1 515 ? -22.781 -65.591 -13.304 1.00 23.12  ? 778  ALA A CB  1 
ATOM   3724 N  N   . ILE A 1 516 ? -24.486 -62.945 -13.709 1.00 22.47  ? 779  ILE A N   1 
ATOM   3725 C  CA  . ILE A 1 516 ? -25.265 -61.828 -13.119 1.00 21.37  ? 779  ILE A CA  1 
ATOM   3726 C  C   . ILE A 1 516 ? -26.658 -61.805 -13.804 1.00 24.97  ? 779  ILE A C   1 
ATOM   3727 O  O   . ILE A 1 516 ? -27.681 -61.692 -13.127 1.00 24.07  ? 779  ILE A O   1 
ATOM   3728 C  CB  . ILE A 1 516 ? -24.544 -60.490 -13.330 1.00 20.34  ? 779  ILE A CB  1 
ATOM   3729 C  CG1 . ILE A 1 516 ? -23.332 -60.360 -12.406 1.00 22.41  ? 779  ILE A CG1 1 
ATOM   3730 C  CG2 . ILE A 1 516 ? -25.464 -59.323 -13.031 1.00 20.33  ? 779  ILE A CG2 1 
ATOM   3731 C  CD1 . ILE A 1 516 ? -22.299 -59.337 -12.929 1.00 23.24  ? 779  ILE A CD1 1 
ATOM   3732 N  N   . CYS A 1 517 ? -26.719 -61.921 -15.136 1.00 21.78  ? 780  CYS A N   1 
ATOM   3733 C  CA  . CYS A 1 517 ? -28.010 -61.864 -15.866 1.00 24.22  ? 780  CYS A CA  1 
ATOM   3734 C  C   . CYS A 1 517 ? -28.855 -63.100 -15.507 1.00 24.58  ? 780  CYS A C   1 
ATOM   3735 O  O   . CYS A 1 517 ? -30.130 -63.018 -15.575 1.00 25.08  ? 780  CYS A O   1 
ATOM   3736 C  CB  . CYS A 1 517 ? -27.783 -61.770 -17.368 1.00 25.68  ? 780  CYS A CB  1 
ATOM   3737 S  SG  . CYS A 1 517 ? -27.135 -60.159 -17.846 1.00 29.32  ? 780  CYS A SG  1 
ATOM   3738 N  N   . SER A 1 518 ? -28.226 -64.188 -15.081 1.00 22.98  ? 781  SER A N   1 
ATOM   3739 C  CA  . SER A 1 518 ? -28.992 -65.396 -14.666 1.00 25.51  ? 781  SER A CA  1 
ATOM   3740 C  C   . SER A 1 518 ? -29.544 -65.184 -13.253 1.00 27.60  ? 781  SER A C   1 
ATOM   3741 O  O   . SER A 1 518 ? -30.543 -65.885 -12.912 1.00 23.77  ? 781  SER A O   1 
ATOM   3742 C  CB  . SER A 1 518 ? -28.192 -66.698 -14.736 1.00 23.97  ? 781  SER A CB  1 
ATOM   3743 O  OG  . SER A 1 518 ? -27.696 -66.958 -16.032 1.00 26.92  ? 781  SER A OG  1 
ATOM   3744 N  N   . ALA A 1 519 ? -28.861 -64.377 -12.430 1.00 23.11  ? 782  ALA A N   1 
ATOM   3745 C  CA  . ALA A 1 519 ? -29.144 -64.196 -10.984 1.00 23.53  ? 782  ALA A CA  1 
ATOM   3746 C  C   . ALA A 1 519 ? -30.167 -63.093 -10.753 1.00 22.75  ? 782  ALA A C   1 
ATOM   3747 O  O   . ALA A 1 519 ? -30.734 -63.058 -9.678  1.00 25.16  ? 782  ALA A O   1 
ATOM   3748 C  CB  . ALA A 1 519 ? -27.886 -63.962 -10.187 1.00 23.31  ? 782  ALA A CB  1 
ATOM   3749 N  N   . VAL A 1 520 ? -30.351 -62.203 -11.698 1.00 22.54  ? 783  VAL A N   1 
ATOM   3750 C  CA  . VAL A 1 520 ? -31.249 -61.031 -11.585 1.00 23.11  ? 783  VAL A CA  1 
ATOM   3751 C  C   . VAL A 1 520 ? -32.526 -61.362 -12.372 1.00 23.69  ? 783  VAL A C   1 
ATOM   3752 O  O   . VAL A 1 520 ? -32.454 -61.896 -13.486 1.00 23.39  ? 783  VAL A O   1 
ATOM   3753 C  CB  . VAL A 1 520 ? -30.560 -59.752 -12.096 1.00 25.37  ? 783  VAL A CB  1 
ATOM   3754 C  CG1 . VAL A 1 520 ? -31.571 -58.599 -12.109 1.00 24.75  ? 783  VAL A CG1 1 
ATOM   3755 C  CG2 . VAL A 1 520 ? -29.363 -59.385 -11.204 1.00 23.68  ? 783  VAL A CG2 1 
ATOM   3756 N  N   . PRO A 1 521 ? -33.746 -61.135 -11.823 1.00 26.10  ? 784  PRO A N   1 
ATOM   3757 C  CA  . PRO A 1 521 ? -34.957 -61.461 -12.567 1.00 25.41  ? 784  PRO A CA  1 
ATOM   3758 C  C   . PRO A 1 521 ? -34.894 -60.962 -14.028 1.00 26.36  ? 784  PRO A C   1 
ATOM   3759 O  O   . PRO A 1 521 ? -34.531 -59.821 -14.310 1.00 25.92  ? 784  PRO A O   1 
ATOM   3760 C  CB  . PRO A 1 521 ? -36.050 -60.783 -11.701 1.00 23.94  ? 784  PRO A CB  1 
ATOM   3761 C  CG  . PRO A 1 521 ? -35.539 -61.012 -10.287 1.00 25.22  ? 784  PRO A CG  1 
ATOM   3762 C  CD  . PRO A 1 521 ? -34.042 -60.702 -10.437 1.00 24.08  ? 784  PRO A CD  1 
ATOM   3763 N  N   A SER A 1 522 ? -35.257 -61.866 -14.932 0.25 27.39  ? 785  SER A N   1 
ATOM   3764 N  N   B SER A 1 522 ? -35.287 -61.849 -14.936 0.25 28.04  ? 785  SER A N   1 
ATOM   3765 C  CA  A SER A 1 522 ? -35.241 -61.697 -16.406 0.25 29.11  ? 785  SER A CA  1 
ATOM   3766 C  CA  B SER A 1 522 ? -35.201 -61.676 -16.407 0.25 30.26  ? 785  SER A CA  1 
ATOM   3767 C  C   A SER A 1 522 ? -35.798 -60.332 -16.807 0.25 29.94  ? 785  SER A C   1 
ATOM   3768 C  C   B SER A 1 522 ? -35.808 -60.338 -16.831 0.25 30.55  ? 785  SER A C   1 
ATOM   3769 O  O   A SER A 1 522 ? -35.170 -59.673 -17.653 0.25 29.35  ? 785  SER A O   1 
ATOM   3770 O  O   B SER A 1 522 ? -35.213 -59.690 -17.711 0.25 29.53  ? 785  SER A O   1 
ATOM   3771 C  CB  A SER A 1 522 ? -36.018 -62.803 -17.052 0.25 31.25  ? 785  SER A CB  1 
ATOM   3772 C  CB  B SER A 1 522 ? -35.856 -62.831 -17.116 0.25 33.21  ? 785  SER A CB  1 
ATOM   3773 O  OG  A SER A 1 522 ? -37.178 -63.096 -16.286 0.25 31.32  ? 785  SER A OG  1 
ATOM   3774 O  OG  B SER A 1 522 ? -35.548 -64.057 -16.467 0.25 35.67  ? 785  SER A OG  1 
ATOM   3775 N  N   . HIS A 1 523 ? -36.954 -59.940 -16.249 1.00 30.41  ? 786  HIS A N   1 
ATOM   3776 C  CA  . HIS A 1 523 ? -37.707 -58.748 -16.731 1.00 28.31  ? 786  HIS A CA  1 
ATOM   3777 C  C   . HIS A 1 523 ? -37.316 -57.486 -16.003 1.00 27.19  ? 786  HIS A C   1 
ATOM   3778 O  O   . HIS A 1 523 ? -37.732 -56.396 -16.440 1.00 31.14  ? 786  HIS A O   1 
ATOM   3779 C  CB  . HIS A 1 523 ? -39.253 -59.019 -16.769 1.00 30.71  ? 786  HIS A CB  1 
ATOM   3780 C  CG  . HIS A 1 523 ? -39.642 -60.112 -17.706 1.00 29.87  ? 786  HIS A CG  1 
ATOM   3781 N  ND1 . HIS A 1 523 ? -39.750 -59.893 -19.088 1.00 35.21  ? 786  HIS A ND1 1 
ATOM   3782 C  CD2 . HIS A 1 523 ? -39.842 -61.434 -17.525 1.00 37.02  ? 786  HIS A CD2 1 
ATOM   3783 C  CE1 . HIS A 1 523 ? -40.035 -61.028 -19.683 1.00 37.66  ? 786  HIS A CE1 1 
ATOM   3784 N  NE2 . HIS A 1 523 ? -40.123 -61.989 -18.759 1.00 32.48  ? 786  HIS A NE2 1 
ATOM   3785 N  N   . TRP A 1 524 ? -36.436 -57.546 -14.999 1.00 27.76  ? 787  TRP A N   1 
ATOM   3786 C  CA  . TRP A 1 524 ? -36.061 -56.312 -14.276 1.00 26.51  ? 787  TRP A CA  1 
ATOM   3787 C  C   . TRP A 1 524 ? -35.154 -55.460 -15.176 1.00 25.54  ? 787  TRP A C   1 
ATOM   3788 O  O   . TRP A 1 524 ? -34.331 -56.020 -15.891 1.00 29.33  ? 787  TRP A O   1 
ATOM   3789 C  CB  . TRP A 1 524 ? -35.454 -56.652 -12.906 1.00 25.55  ? 787  TRP A CB  1 
ATOM   3790 C  CG  . TRP A 1 524 ? -36.456 -57.107 -11.872 1.00 27.33  ? 787  TRP A CG  1 
ATOM   3791 C  CD1 . TRP A 1 524 ? -37.783 -57.422 -12.043 1.00 25.28  ? 787  TRP A CD1 1 
ATOM   3792 C  CD2 . TRP A 1 524 ? -36.155 -57.397 -10.495 1.00 26.05  ? 787  TRP A CD2 1 
ATOM   3793 N  NE1 . TRP A 1 524 ? -38.334 -57.859 -10.861 1.00 28.68  ? 787  TRP A NE1 1 
ATOM   3794 C  CE2 . TRP A 1 524 ? -37.368 -57.784 -9.866  1.00 29.02  ? 787  TRP A CE2 1 
ATOM   3795 C  CE3 . TRP A 1 524 ? -34.988 -57.287 -9.716  1.00 30.38  ? 787  TRP A CE3 1 
ATOM   3796 C  CZ2 . TRP A 1 524 ? -37.427 -58.102 -8.502  1.00 30.41  ? 787  TRP A CZ2 1 
ATOM   3797 C  CZ3 . TRP A 1 524 ? -35.064 -57.592 -8.358  1.00 28.16  ? 787  TRP A CZ3 1 
ATOM   3798 C  CH2 . TRP A 1 524 ? -36.253 -57.993 -7.769  1.00 26.17  ? 787  TRP A CH2 1 
ATOM   3799 N  N   . VAL A 1 525 ? -35.383 -54.160 -15.166 1.00 27.43  ? 788  VAL A N   1 
ATOM   3800 C  CA  . VAL A 1 525 ? -34.807 -53.181 -16.117 1.00 30.68  ? 788  VAL A CA  1 
ATOM   3801 C  C   . VAL A 1 525 ? -33.472 -52.685 -15.575 1.00 32.78  ? 788  VAL A C   1 
ATOM   3802 O  O   . VAL A 1 525 ? -33.407 -52.104 -14.490 1.00 27.30  ? 788  VAL A O   1 
ATOM   3803 C  CB  . VAL A 1 525 ? -35.779 -51.997 -16.332 1.00 37.44  ? 788  VAL A CB  1 
ATOM   3804 C  CG1 . VAL A 1 525 ? -35.199 -50.956 -17.305 1.00 34.53  ? 788  VAL A CG1 1 
ATOM   3805 C  CG2 . VAL A 1 525 ? -37.179 -52.452 -16.767 1.00 36.95  ? 788  VAL A CG2 1 
ATOM   3806 N  N   . PRO A 1 526 ? -32.386 -52.747 -16.356 1.00 32.74  ? 789  PRO A N   1 
ATOM   3807 C  CA  . PRO A 1 526 ? -31.119 -52.165 -15.908 1.00 31.36  ? 789  PRO A CA  1 
ATOM   3808 C  C   . PRO A 1 526 ? -31.250 -50.684 -15.544 1.00 32.17  ? 789  PRO A C   1 
ATOM   3809 O  O   . PRO A 1 526 ? -31.933 -49.965 -16.263 1.00 30.40  ? 789  PRO A O   1 
ATOM   3810 C  CB  . PRO A 1 526 ? -30.221 -52.221 -17.147 1.00 29.70  ? 789  PRO A CB  1 
ATOM   3811 C  CG  . PRO A 1 526 ? -30.817 -53.253 -18.029 1.00 32.51  ? 789  PRO A CG  1 
ATOM   3812 C  CD  . PRO A 1 526 ? -32.292 -53.326 -17.699 1.00 33.32  ? 789  PRO A CD  1 
ATOM   3813 N  N   . THR A 1 527 ? -30.562 -50.238 -14.496 1.00 35.42  ? 790  THR A N   1 
ATOM   3814 C  CA  . THR A 1 527 ? -30.610 -48.828 -14.044 1.00 43.28  ? 790  THR A CA  1 
ATOM   3815 C  C   . THR A 1 527 ? -29.225 -48.302 -13.746 1.00 48.78  ? 790  THR A C   1 
ATOM   3816 O  O   . THR A 1 527 ? -28.306 -49.088 -13.499 1.00 43.42  ? 790  THR A O   1 
ATOM   3817 C  CB  . THR A 1 527 ? -31.305 -48.599 -12.682 1.00 55.22  ? 790  THR A CB  1 
ATOM   3818 O  OG1 . THR A 1 527 ? -30.761 -49.462 -11.665 1.00 59.07  ? 790  THR A OG1 1 
ATOM   3819 C  CG2 . THR A 1 527 ? -32.800 -48.765 -12.766 1.00 61.68  ? 790  THR A CG2 1 
ATOM   3820 N  N   . SER A 1 528 ? -29.091 -46.981 -13.755 0.50 45.85  ? 791  SER A N   1 
ATOM   3821 C  CA  . SER A 1 528 ? -27.898 -46.238 -13.284 0.50 49.35  ? 791  SER A CA  1 
ATOM   3822 C  C   . SER A 1 528 ? -28.366 -44.830 -12.919 0.50 48.28  ? 791  SER A C   1 
ATOM   3823 O  O   . SER A 1 528 ? -29.026 -44.204 -13.770 0.50 51.29  ? 791  SER A O   1 
ATOM   3824 C  CB  . SER A 1 528 ? -26.801 -46.234 -14.324 0.50 48.48  ? 791  SER A CB  1 
ATOM   3825 O  OG  . SER A 1 528 ? -25.553 -45.873 -13.743 0.50 51.54  ? 791  SER A OG  1 
ATOM   3826 N  N   . ARG A 1 529 ? -28.109 -44.393 -11.682 0.50 45.16  ? 792  ARG A N   1 
ATOM   3827 C  CA  . ARG A 1 529 ? -28.506 -43.049 -11.179 0.50 45.36  ? 792  ARG A CA  1 
ATOM   3828 C  C   . ARG A 1 529 ? -27.774 -41.970 -11.985 0.50 45.14  ? 792  ARG A C   1 
ATOM   3829 O  O   . ARG A 1 529 ? -28.326 -40.856 -12.045 0.50 48.60  ? 792  ARG A O   1 
ATOM   3830 C  CB  . ARG A 1 529 ? -28.202 -42.918 -9.685  0.50 44.13  ? 792  ARG A CB  1 
ATOM   3831 C  CG  . ARG A 1 529 ? -29.235 -43.588 -8.794  0.50 44.66  ? 792  ARG A CG  1 
ATOM   3832 C  CD  . ARG A 1 529 ? -28.968 -43.343 -7.320  0.50 43.34  ? 792  ARG A CD  1 
ATOM   3833 N  NE  . ARG A 1 529 ? -29.637 -44.345 -6.507  0.50 42.75  ? 792  ARG A NE  1 
ATOM   3834 C  CZ  . ARG A 1 529 ? -29.686 -44.331 -5.187  0.50 39.46  ? 792  ARG A CZ  1 
ATOM   3835 N  NH1 . ARG A 1 529 ? -29.109 -43.344 -4.524  0.50 36.78  ? 792  ARG A NH1 1 
ATOM   3836 N  NH2 . ARG A 1 529 ? -30.326 -45.292 -4.545  0.50 36.71  ? 792  ARG A NH2 1 
ATOM   3837 N  N   . ALA A 1 536 ? -21.924 -41.045 -25.934 0.50 95.19  ? 799  ALA A N   1 
ATOM   3838 C  CA  . ALA A 1 536 ? -21.659 -42.495 -26.093 0.50 94.72  ? 799  ALA A CA  1 
ATOM   3839 C  C   . ALA A 1 536 ? -22.990 -43.250 -26.202 0.50 92.89  ? 799  ALA A C   1 
ATOM   3840 O  O   . ALA A 1 536 ? -23.987 -42.795 -25.597 0.50 91.66  ? 799  ALA A O   1 
ATOM   3841 C  CB  . ALA A 1 536 ? -20.827 -43.000 -24.936 0.50 95.07  ? 799  ALA A CB  1 
ATOM   3842 N  N   . THR A 1 537 ? -22.996 -44.360 -26.949 0.50 87.08  ? 800  THR A N   1 
ATOM   3843 C  CA  . THR A 1 537 ? -24.169 -45.255 -27.139 0.50 83.28  ? 800  THR A CA  1 
ATOM   3844 C  C   . THR A 1 537 ? -24.147 -46.356 -26.071 0.50 72.27  ? 800  THR A C   1 
ATOM   3845 O  O   . THR A 1 537 ? -23.415 -47.367 -26.265 0.50 68.58  ? 800  THR A O   1 
ATOM   3846 C  CB  . THR A 1 537 ? -24.215 -45.848 -28.555 0.50 88.85  ? 800  THR A CB  1 
ATOM   3847 O  OG1 . THR A 1 537 ? -22.918 -46.339 -28.897 0.50 93.68  ? 800  THR A OG1 1 
ATOM   3848 C  CG2 . THR A 1 537 ? -24.674 -44.849 -29.595 0.50 91.99  ? 800  THR A CG2 1 
ATOM   3849 N  N   A HIS A 1 538 ? -24.913 -46.154 -24.992 0.25 59.14  ? 801  HIS A N   1 
ATOM   3850 N  N   B HIS A 1 538 ? -24.943 -46.136 -25.011 0.25 63.04  ? 801  HIS A N   1 
ATOM   3851 C  CA  A HIS A 1 538 ? -25.136 -47.141 -23.901 0.25 48.18  ? 801  HIS A CA  1 
ATOM   3852 C  CA  B HIS A 1 538 ? -25.185 -47.093 -23.898 0.25 53.02  ? 801  HIS A CA  1 
ATOM   3853 C  C   A HIS A 1 538 ? -26.282 -48.069 -24.313 0.25 39.99  ? 801  HIS A C   1 
ATOM   3854 C  C   B HIS A 1 538 ? -26.305 -48.054 -24.314 0.25 42.81  ? 801  HIS A C   1 
ATOM   3855 O  O   A HIS A 1 538 ? -27.367 -47.980 -23.725 0.25 37.83  ? 801  HIS A O   1 
ATOM   3856 O  O   B HIS A 1 538 ? -27.396 -47.985 -23.732 0.25 40.60  ? 801  HIS A O   1 
ATOM   3857 C  CB  A HIS A 1 538 ? -25.418 -46.429 -22.577 0.25 46.19  ? 801  HIS A CB  1 
ATOM   3858 C  CB  B HIS A 1 538 ? -25.496 -46.329 -22.604 0.25 54.32  ? 801  HIS A CB  1 
ATOM   3859 C  CG  A HIS A 1 538 ? -24.290 -45.590 -22.090 0.25 43.52  ? 801  HIS A CG  1 
ATOM   3860 C  CG  B HIS A 1 538 ? -26.338 -45.111 -22.808 0.25 54.09  ? 801  HIS A CG  1 
ATOM   3861 N  ND1 A HIS A 1 538 ? -24.150 -45.255 -20.755 0.25 42.02  ? 801  HIS A ND1 1 
ATOM   3862 N  ND1 B HIS A 1 538 ? -26.087 -43.922 -22.148 0.25 54.01  ? 801  HIS A ND1 1 
ATOM   3863 C  CD2 A HIS A 1 538 ? -23.245 -45.032 -22.741 0.25 40.78  ? 801  HIS A CD2 1 
ATOM   3864 C  CD2 B HIS A 1 538 ? -27.402 -44.883 -23.606 0.25 52.35  ? 801  HIS A CD2 1 
ATOM   3865 C  CE1 A HIS A 1 538 ? -23.067 -44.520 -20.606 0.25 41.65  ? 801  HIS A CE1 1 
ATOM   3866 C  CE1 B HIS A 1 538 ? -26.971 -43.021 -22.519 0.25 54.15  ? 801  HIS A CE1 1 
ATOM   3867 N  NE2 A HIS A 1 538 ? -22.495 -44.366 -21.813 0.25 41.48  ? 801  HIS A NE2 1 
ATOM   3868 N  NE2 B HIS A 1 538 ? -27.790 -43.584 -23.413 0.25 53.21  ? 801  HIS A NE2 1 
ATOM   3869 N  N   . GLU A 1 539 ? -26.033 -48.926 -25.299 0.50 35.30  ? 802  GLU A N   1 
ATOM   3870 C  CA  . GLU A 1 539 ? -27.043 -49.846 -25.882 0.50 34.25  ? 802  GLU A CA  1 
ATOM   3871 C  C   . GLU A 1 539 ? -27.371 -50.976 -24.904 0.50 33.22  ? 802  GLU A C   1 
ATOM   3872 O  O   . GLU A 1 539 ? -28.324 -51.734 -25.196 0.50 28.08  ? 802  GLU A O   1 
ATOM   3873 C  CB  . GLU A 1 539 ? -26.537 -50.418 -27.201 0.50 37.03  ? 802  GLU A CB  1 
ATOM   3874 C  CG  . GLU A 1 539 ? -26.582 -49.408 -28.331 0.50 40.32  ? 802  GLU A CG  1 
ATOM   3875 C  CD  . GLU A 1 539 ? -25.321 -48.585 -28.503 0.50 40.86  ? 802  GLU A CD  1 
ATOM   3876 O  OE1 . GLU A 1 539 ? -25.132 -48.047 -29.615 0.50 43.89  ? 802  GLU A OE1 1 
ATOM   3877 O  OE2 . GLU A 1 539 ? -24.533 -48.481 -27.536 0.50 43.97  ? 802  GLU A OE2 1 
ATOM   3878 N  N   . TRP A 1 540 ? -26.608 -51.105 -23.808 0.50 29.72  ? 803  TRP A N   1 
ATOM   3879 C  CA  . TRP A 1 540 ? -26.844 -52.151 -22.777 0.50 28.96  ? 803  TRP A CA  1 
ATOM   3880 C  C   . TRP A 1 540 ? -27.952 -51.708 -21.807 0.50 28.68  ? 803  TRP A C   1 
ATOM   3881 O  O   . TRP A 1 540 ? -28.375 -52.527 -20.989 0.50 27.69  ? 803  TRP A O   1 
ATOM   3882 C  CB  . TRP A 1 540 ? -25.536 -52.472 -22.041 0.50 28.27  ? 803  TRP A CB  1 
ATOM   3883 C  CG  . TRP A 1 540 ? -24.964 -51.296 -21.320 0.50 25.69  ? 803  TRP A CG  1 
ATOM   3884 C  CD1 . TRP A 1 540 ? -25.244 -50.894 -20.051 0.50 25.40  ? 803  TRP A CD1 1 
ATOM   3885 C  CD2 . TRP A 1 540 ? -24.033 -50.337 -21.851 0.50 26.39  ? 803  TRP A CD2 1 
ATOM   3886 N  NE1 . TRP A 1 540 ? -24.555 -49.752 -19.751 0.50 27.20  ? 803  TRP A NE1 1 
ATOM   3887 C  CE2 . TRP A 1 540 ? -23.793 -49.392 -20.832 0.50 28.15  ? 803  TRP A CE2 1 
ATOM   3888 C  CE3 . TRP A 1 540 ? -23.373 -50.198 -23.073 0.50 27.30  ? 803  TRP A CE3 1 
ATOM   3889 C  CZ2 . TRP A 1 540 ? -22.923 -48.323 -21.004 0.50 28.37  ? 803  TRP A CZ2 1 
ATOM   3890 C  CZ3 . TRP A 1 540 ? -22.513 -49.137 -23.242 0.50 28.30  ? 803  TRP A CZ3 1 
ATOM   3891 C  CH2 . TRP A 1 540 ? -22.287 -48.221 -22.219 0.50 29.13  ? 803  TRP A CH2 1 
ATOM   3892 N  N   . MET A 1 541 ? -28.394 -50.450 -21.877 0.50 31.21  ? 804  MET A N   1 
ATOM   3893 C  CA  . MET A 1 541 ? -29.497 -49.940 -21.019 0.50 33.55  ? 804  MET A CA  1 
ATOM   3894 C  C   . MET A 1 541 ? -30.835 -50.279 -21.700 0.50 34.52  ? 804  MET A C   1 
ATOM   3895 O  O   . MET A 1 541 ? -31.491 -49.348 -22.219 0.50 35.40  ? 804  MET A O   1 
ATOM   3896 C  CB  . MET A 1 541 ? -29.372 -48.432 -20.778 0.50 34.49  ? 804  MET A CB  1 
ATOM   3897 C  CG  . MET A 1 541 ? -28.044 -48.007 -20.135 0.50 36.69  ? 804  MET A CG  1 
ATOM   3898 S  SD  . MET A 1 541 ? -27.710 -48.748 -18.503 0.50 36.81  ? 804  MET A SD  1 
ATOM   3899 C  CE  . MET A 1 541 ? -29.001 -47.988 -17.519 0.50 36.87  ? 804  MET A CE  1 
ATOM   3900 N  N   . THR A 1 542 ? -31.217 -51.564 -21.671 1.00 34.45  ? 805  THR A N   1 
ATOM   3901 C  CA  . THR A 1 542 ? -32.375 -52.137 -22.419 1.00 35.14  ? 805  THR A CA  1 
ATOM   3902 C  C   . THR A 1 542 ? -32.738 -53.516 -21.866 1.00 34.17  ? 805  THR A C   1 
ATOM   3903 O  O   . THR A 1 542 ? -31.861 -54.155 -21.248 1.00 33.37  ? 805  THR A O   1 
ATOM   3904 C  CB  . THR A 1 542 ? -32.000 -52.372 -23.885 1.00 36.91  ? 805  THR A CB  1 
ATOM   3905 O  OG1 . THR A 1 542 ? -33.099 -52.915 -24.613 1.00 35.71  ? 805  THR A OG1 1 
ATOM   3906 C  CG2 . THR A 1 542 ? -30.851 -53.349 -24.026 1.00 45.18  ? 805  THR A CG2 1 
ATOM   3907 N  N   . THR A 1 543 ? -33.972 -53.994 -22.083 1.00 29.84  ? 806  THR A N   1 
ATOM   3908 C  CA  . THR A 1 543 ? -34.405 -55.363 -21.726 1.00 31.93  ? 806  THR A CA  1 
ATOM   3909 C  C   . THR A 1 543 ? -34.487 -56.204 -22.995 1.00 31.18  ? 806  THR A C   1 
ATOM   3910 O  O   . THR A 1 543 ? -34.816 -57.384 -22.888 1.00 33.02  ? 806  THR A O   1 
ATOM   3911 C  CB  . THR A 1 543 ? -35.729 -55.275 -20.949 1.00 39.45  ? 806  THR A CB  1 
ATOM   3912 O  OG1 . THR A 1 543 ? -36.642 -54.737 -21.896 1.00 39.22  ? 806  THR A OG1 1 
ATOM   3913 C  CG2 . THR A 1 543 ? -35.612 -54.374 -19.734 1.00 41.05  ? 806  THR A CG2 1 
ATOM   3914 N  N   . GLU A 1 544 ? -34.121 -55.649 -24.153 1.00 33.49  ? 807  GLU A N   1 
ATOM   3915 C  CA  . GLU A 1 544 ? -33.969 -56.471 -25.382 1.00 31.23  ? 807  GLU A CA  1 
ATOM   3916 C  C   . GLU A 1 544 ? -32.912 -57.584 -25.197 1.00 33.93  ? 807  GLU A C   1 
ATOM   3917 O  O   . GLU A 1 544 ? -32.007 -57.442 -24.387 1.00 31.43  ? 807  GLU A O   1 
ATOM   3918 C  CB  . GLU A 1 544 ? -33.628 -55.573 -26.549 1.00 37.43  ? 807  GLU A CB  1 
ATOM   3919 C  CG  . GLU A 1 544 ? -33.654 -56.292 -27.868 1.00 44.33  ? 807  GLU A CG  1 
ATOM   3920 C  CD  . GLU A 1 544 ? -33.609 -55.329 -29.053 1.00 50.64  ? 807  GLU A CD  1 
ATOM   3921 O  OE1 . GLU A 1 544 ? -33.996 -55.746 -30.171 1.00 57.36  ? 807  GLU A OE1 1 
ATOM   3922 O  OE2 . GLU A 1 544 ? -33.215 -54.146 -28.843 1.00 38.97  ? 807  GLU A OE2 1 
ATOM   3923 N  N   . ASP A 1 545 ? -33.062 -58.699 -25.905 1.00 32.34  ? 808  ASP A N   1 
ATOM   3924 C  CA  . ASP A 1 545 ? -32.151 -59.871 -25.863 1.00 34.65  ? 808  ASP A CA  1 
ATOM   3925 C  C   . ASP A 1 545 ? -30.713 -59.425 -26.260 1.00 32.07  ? 808  ASP A C   1 
ATOM   3926 O  O   . ASP A 1 545 ? -30.585 -58.774 -27.300 1.00 29.23  ? 808  ASP A O   1 
ATOM   3927 C  CB  . ASP A 1 545 ? -32.691 -60.919 -26.829 1.00 41.24  ? 808  ASP A CB  1 
ATOM   3928 C  CG  . ASP A 1 545 ? -31.861 -62.178 -26.939 1.00 48.28  ? 808  ASP A CG  1 
ATOM   3929 O  OD1 . ASP A 1 545 ? -30.744 -62.079 -27.374 1.00 50.24  ? 808  ASP A OD1 1 
ATOM   3930 O  OD2 . ASP A 1 545 ? -32.375 -63.244 -26.632 1.00 56.60  ? 808  ASP A OD2 1 
ATOM   3931 N  N   . MET A 1 546 ? -29.670 -59.770 -25.483 1.00 31.87  ? 809  MET A N   1 
ATOM   3932 C  CA  . MET A 1 546 ? -28.291 -59.208 -25.699 1.00 31.35  ? 809  MET A CA  1 
ATOM   3933 C  C   . MET A 1 546 ? -27.679 -59.750 -27.002 1.00 30.39  ? 809  MET A C   1 
ATOM   3934 O  O   . MET A 1 546 ? -26.865 -59.001 -27.607 1.00 27.44  ? 809  MET A O   1 
ATOM   3935 C  CB  . MET A 1 546 ? -27.365 -59.429 -24.483 1.00 30.96  ? 809  MET A CB  1 
ATOM   3936 C  CG  . MET A 1 546 ? -27.629 -58.408 -23.355 1.00 29.18  ? 809  MET A CG  1 
ATOM   3937 S  SD  . MET A 1 546 ? -27.595 -56.593 -23.780 1.00 40.94  ? 809  MET A SD  1 
ATOM   3938 C  CE  . MET A 1 546 ? -29.273 -56.204 -24.203 1.00 54.34  ? 809  MET A CE  1 
ATOM   3939 N  N   . LEU A 1 547 ? -28.066 -60.942 -27.481 1.00 27.49  ? 810  LEU A N   1 
ATOM   3940 C  CA  . LEU A 1 547 ? -27.602 -61.396 -28.809 1.00 30.25  ? 810  LEU A CA  1 
ATOM   3941 C  C   . LEU A 1 547 ? -28.150 -60.470 -29.912 1.00 30.45  ? 810  LEU A C   1 
ATOM   3942 O  O   . LEU A 1 547 ? -27.413 -60.187 -30.881 1.00 27.25  ? 810  LEU A O   1 
ATOM   3943 C  CB  . LEU A 1 547 ? -27.942 -62.853 -29.115 1.00 31.59  ? 810  LEU A CB  1 
ATOM   3944 C  CG  . LEU A 1 547 ? -27.195 -63.431 -30.322 1.00 33.64  ? 810  LEU A CG  1 
ATOM   3945 C  CD1 . LEU A 1 547 ? -25.666 -63.450 -30.107 1.00 33.77  ? 810  LEU A CD1 1 
ATOM   3946 C  CD2 . LEU A 1 547 ? -27.656 -64.853 -30.624 1.00 35.10  ? 810  LEU A CD2 1 
ATOM   3947 N  N   . THR A 1 548 ? -29.414 -60.098 -29.851 1.00 27.31  ? 811  THR A N   1 
ATOM   3948 C  CA  . THR A 1 548 ? -30.032 -59.207 -30.848 1.00 30.12  ? 811  THR A CA  1 
ATOM   3949 C  C   . THR A 1 548 ? -29.319 -57.857 -30.795 1.00 27.70  ? 811  THR A C   1 
ATOM   3950 O  O   . THR A 1 548 ? -29.044 -57.286 -31.862 1.00 26.49  ? 811  THR A O   1 
ATOM   3951 C  CB  . THR A 1 548 ? -31.541 -59.089 -30.589 1.00 32.76  ? 811  THR A CB  1 
ATOM   3952 O  OG1 . THR A 1 548 ? -32.069 -60.419 -30.695 1.00 34.18  ? 811  THR A OG1 1 
ATOM   3953 C  CG2 . THR A 1 548 ? -32.179 -58.125 -31.551 1.00 30.74  ? 811  THR A CG2 1 
ATOM   3954 N  N   . VAL A 1 549 ? -29.055 -57.322 -29.604 1.00 27.72  ? 812  VAL A N   1 
ATOM   3955 C  CA  . VAL A 1 549 ? -28.340 -56.015 -29.520 1.00 29.60  ? 812  VAL A CA  1 
ATOM   3956 C  C   . VAL A 1 549 ? -26.910 -56.175 -30.082 1.00 23.73  ? 812  VAL A C   1 
ATOM   3957 O  O   . VAL A 1 549 ? -26.401 -55.283 -30.847 1.00 25.74  ? 812  VAL A O   1 
ATOM   3958 C  CB  . VAL A 1 549 ? -28.319 -55.468 -28.080 1.00 28.67  ? 812  VAL A CB  1 
ATOM   3959 C  CG1 . VAL A 1 549 ? -27.606 -54.117 -28.044 1.00 30.92  ? 812  VAL A CG1 1 
ATOM   3960 C  CG2 . VAL A 1 549 ? -29.730 -55.332 -27.517 1.00 35.05  ? 812  VAL A CG2 1 
ATOM   3961 N  N   . TRP A 1 550 ? -26.246 -57.285 -29.766 1.00 25.27  ? 813  TRP A N   1 
ATOM   3962 C  CA  . TRP A 1 550 ? -24.849 -57.512 -30.235 1.00 24.27  ? 813  TRP A CA  1 
ATOM   3963 C  C   . TRP A 1 550 ? -24.860 -57.459 -31.759 1.00 27.87  ? 813  TRP A C   1 
ATOM   3964 O  O   . TRP A 1 550 ? -24.040 -56.737 -32.383 1.00 28.10  ? 813  TRP A O   1 
ATOM   3965 C  CB  . TRP A 1 550 ? -24.283 -58.825 -29.700 1.00 23.93  ? 813  TRP A CB  1 
ATOM   3966 C  CG  . TRP A 1 550 ? -22.821 -58.972 -29.986 1.00 24.57  ? 813  TRP A CG  1 
ATOM   3967 C  CD1 . TRP A 1 550 ? -21.766 -58.744 -29.121 1.00 26.37  ? 813  TRP A CD1 1 
ATOM   3968 C  CD2 . TRP A 1 550 ? -22.212 -59.395 -31.211 1.00 23.11  ? 813  TRP A CD2 1 
ATOM   3969 N  NE1 . TRP A 1 550 ? -20.566 -58.982 -29.729 1.00 23.60  ? 813  TRP A NE1 1 
ATOM   3970 C  CE2 . TRP A 1 550 ? -20.802 -59.347 -31.024 1.00 25.69  ? 813  TRP A CE2 1 
ATOM   3971 C  CE3 . TRP A 1 550 ? -22.698 -59.831 -32.450 1.00 26.58  ? 813  TRP A CE3 1 
ATOM   3972 C  CZ2 . TRP A 1 550 ? -19.888 -59.739 -32.005 1.00 25.65  ? 813  TRP A CZ2 1 
ATOM   3973 C  CZ3 . TRP A 1 550 ? -21.794 -60.154 -33.431 1.00 27.49  ? 813  TRP A CZ3 1 
ATOM   3974 C  CH2 . TRP A 1 550 ? -20.413 -60.104 -33.218 1.00 28.00  ? 813  TRP A CH2 1 
ATOM   3975 N  N   . ASN A 1 551 ? -25.785 -58.209 -32.367 1.00 27.31  ? 814  ASN A N   1 
ATOM   3976 C  CA  . ASN A 1 551 ? -25.913 -58.231 -33.848 1.00 27.36  ? 814  ASN A CA  1 
ATOM   3977 C  C   . ASN A 1 551 ? -26.141 -56.835 -34.409 1.00 27.06  ? 814  ASN A C   1 
ATOM   3978 O  O   . ASN A 1 551 ? -25.595 -56.543 -35.493 1.00 28.46  ? 814  ASN A O   1 
ATOM   3979 C  CB  . ASN A 1 551 ? -27.025 -59.159 -34.328 1.00 29.28  ? 814  ASN A CB  1 
ATOM   3980 C  CG  . ASN A 1 551 ? -26.496 -60.551 -34.543 1.00 31.64  ? 814  ASN A CG  1 
ATOM   3981 O  OD1 . ASN A 1 551 ? -25.614 -60.786 -35.366 1.00 38.12  ? 814  ASN A OD1 1 
ATOM   3982 N  ND2 . ASN A 1 551 ? -27.065 -61.506 -33.834 1.00 37.94  ? 814  ASN A ND2 1 
ATOM   3983 N  N   . ARG A 1 552 ? -26.989 -56.039 -33.786 1.00 27.61  ? 815  ARG A N   1 
ATOM   3984 C  CA  . ARG A 1 552 ? -27.306 -54.706 -34.306 1.00 28.71  ? 815  ARG A CA  1 
ATOM   3985 C  C   . ARG A 1 552 ? -26.039 -53.850 -34.258 1.00 31.15  ? 815  ARG A C   1 
ATOM   3986 O  O   . ARG A 1 552 ? -25.769 -53.150 -35.226 1.00 34.09  ? 815  ARG A O   1 
ATOM   3987 C  CB  . ARG A 1 552 ? -28.460 -54.095 -33.537 1.00 28.98  ? 815  ARG A CB  1 
ATOM   3988 C  CG  . ARG A 1 552 ? -28.923 -52.759 -34.090 1.00 33.00  ? 815  ARG A CG  1 
ATOM   3989 C  CD  . ARG A 1 552 ? -29.890 -52.049 -33.148 1.00 40.29  ? 815  ARG A CD  1 
ATOM   3990 N  NE  . ARG A 1 552 ? -31.029 -52.915 -32.945 1.00 52.12  ? 815  ARG A NE  1 
ATOM   3991 C  CZ  . ARG A 1 552 ? -31.524 -53.328 -31.770 1.00 49.41  ? 815  ARG A CZ  1 
ATOM   3992 N  NH1 . ARG A 1 552 ? -31.058 -52.906 -30.601 1.00 46.35  ? 815  ARG A NH1 1 
ATOM   3993 N  NH2 . ARG A 1 552 ? -32.557 -54.137 -31.804 1.00 53.05  ? 815  ARG A NH2 1 
ATOM   3994 N  N   . VAL A 1 553 ? -25.282 -53.915 -33.158 1.00 27.39  ? 816  VAL A N   1 
ATOM   3995 C  CA  . VAL A 1 553 ? -24.166 -52.959 -32.897 1.00 30.00  ? 816  VAL A CA  1 
ATOM   3996 C  C   . VAL A 1 553 ? -22.917 -53.367 -33.722 1.00 28.53  ? 816  VAL A C   1 
ATOM   3997 O  O   . VAL A 1 553 ? -22.264 -52.515 -34.374 1.00 29.09  ? 816  VAL A O   1 
ATOM   3998 C  CB  . VAL A 1 553 ? -23.898 -52.952 -31.385 1.00 30.69  ? 816  VAL A CB  1 
ATOM   3999 C  CG1 . VAL A 1 553 ? -22.561 -52.339 -31.063 1.00 34.04  ? 816  VAL A CG1 1 
ATOM   4000 C  CG2 . VAL A 1 553 ? -25.006 -52.213 -30.676 1.00 29.84  ? 816  VAL A CG2 1 
ATOM   4001 N  N   . TRP A 1 554 ? -22.576 -54.649 -33.726 1.00 26.10  ? 817  TRP A N   1 
ATOM   4002 C  CA  . TRP A 1 554 ? -21.308 -55.158 -34.271 1.00 25.36  ? 817  TRP A CA  1 
ATOM   4003 C  C   . TRP A 1 554 ? -21.477 -55.553 -35.714 1.00 30.21  ? 817  TRP A C   1 
ATOM   4004 O  O   . TRP A 1 554 ? -20.474 -55.589 -36.382 1.00 28.89  ? 817  TRP A O   1 
ATOM   4005 C  CB  . TRP A 1 554 ? -20.755 -56.304 -33.424 1.00 27.01  ? 817  TRP A CB  1 
ATOM   4006 C  CG  . TRP A 1 554 ? -20.279 -55.810 -32.075 1.00 25.83  ? 817  TRP A CG  1 
ATOM   4007 C  CD1 . TRP A 1 554 ? -20.869 -55.974 -30.867 1.00 23.35  ? 817  TRP A CD1 1 
ATOM   4008 C  CD2 . TRP A 1 554 ? -19.057 -55.097 -31.816 1.00 23.51  ? 817  TRP A CD2 1 
ATOM   4009 N  NE1 . TRP A 1 554 ? -20.132 -55.377 -29.878 1.00 23.41  ? 817  TRP A NE1 1 
ATOM   4010 C  CE2 . TRP A 1 554 ? -18.994 -54.862 -30.429 1.00 23.76  ? 817  TRP A CE2 1 
ATOM   4011 C  CE3 . TRP A 1 554 ? -18.026 -54.634 -32.625 1.00 22.73  ? 817  TRP A CE3 1 
ATOM   4012 C  CZ2 . TRP A 1 554 ? -17.935 -54.164 -29.841 1.00 25.06  ? 817  TRP A CZ2 1 
ATOM   4013 C  CZ3 . TRP A 1 554 ? -16.956 -53.976 -32.047 1.00 22.77  ? 817  TRP A CZ3 1 
ATOM   4014 C  CH2 . TRP A 1 554 ? -16.934 -53.709 -30.684 1.00 24.24  ? 817  TRP A CH2 1 
ATOM   4015 N  N   . ILE A 1 555 ? -22.701 -55.850 -36.191 1.00 30.46  ? 818  ILE A N   1 
ATOM   4016 C  CA  . ILE A 1 555 ? -22.865 -56.341 -37.591 1.00 28.43  ? 818  ILE A CA  1 
ATOM   4017 C  C   . ILE A 1 555 ? -23.714 -55.314 -38.363 1.00 31.52  ? 818  ILE A C   1 
ATOM   4018 O  O   . ILE A 1 555 ? -23.130 -54.605 -39.207 1.00 30.95  ? 818  ILE A O   1 
ATOM   4019 C  CB  . ILE A 1 555 ? -23.474 -57.751 -37.674 1.00 31.04  ? 818  ILE A CB  1 
ATOM   4020 C  CG1 . ILE A 1 555 ? -22.705 -58.806 -36.874 1.00 29.51  ? 818  ILE A CG1 1 
ATOM   4021 C  CG2 . ILE A 1 555 ? -23.592 -58.195 -39.149 1.00 32.01  ? 818  ILE A CG2 1 
ATOM   4022 C  CD1 . ILE A 1 555 ? -21.290 -58.869 -37.182 1.00 31.43  ? 818  ILE A CD1 1 
ATOM   4023 N  N   . GLN A 1 556 ? -25.012 -55.167 -38.018 1.00 34.21  ? 819  GLN A N   1 
ATOM   4024 C  CA  . GLN A 1 556 ? -26.021 -54.500 -38.896 1.00 34.17  ? 819  GLN A CA  1 
ATOM   4025 C  C   . GLN A 1 556 ? -25.618 -53.038 -39.075 1.00 35.91  ? 819  GLN A C   1 
ATOM   4026 O  O   . GLN A 1 556 ? -25.515 -52.611 -40.200 1.00 34.54  ? 819  GLN A O   1 
ATOM   4027 C  CB  . GLN A 1 556 ? -27.432 -54.639 -38.322 1.00 40.86  ? 819  GLN A CB  1 
ATOM   4028 C  CG  . GLN A 1 556 ? -28.526 -53.975 -39.172 1.00 47.14  ? 819  GLN A CG  1 
ATOM   4029 C  CD  . GLN A 1 556 ? -29.792 -53.626 -38.409 1.00 62.96  ? 819  GLN A CD  1 
ATOM   4030 O  OE1 . GLN A 1 556 ? -30.340 -52.522 -38.546 1.00 70.09  ? 819  GLN A OE1 1 
ATOM   4031 N  NE2 . GLN A 1 556 ? -30.262 -54.543 -37.566 1.00 55.04  ? 819  GLN A NE2 1 
ATOM   4032 N  N   . GLU A 1 557 ? -25.344 -52.320 -37.982 1.00 31.88  ? 820  GLU A N   1 
ATOM   4033 C  CA  . GLU A 1 557 ? -25.114 -50.859 -37.980 1.00 32.94  ? 820  GLU A CA  1 
ATOM   4034 C  C   . GLU A 1 557 ? -23.607 -50.543 -38.044 1.00 32.18  ? 820  GLU A C   1 
ATOM   4035 O  O   . GLU A 1 557 ? -23.262 -49.368 -37.926 1.00 35.10  ? 820  GLU A O   1 
ATOM   4036 C  CB  . GLU A 1 557 ? -25.731 -50.221 -36.724 1.00 33.91  ? 820  GLU A CB  1 
ATOM   4037 C  CG  . GLU A 1 557 ? -27.223 -50.489 -36.595 1.00 43.64  ? 820  GLU A CG  1 
ATOM   4038 C  CD  . GLU A 1 557 ? -27.981 -49.729 -35.504 1.00 52.30  ? 820  GLU A CD  1 
ATOM   4039 O  OE1 . GLU A 1 557 ? -27.339 -49.232 -34.541 1.00 57.34  ? 820  GLU A OE1 1 
ATOM   4040 O  OE2 . GLU A 1 557 ? -29.239 -49.652 -35.607 1.00 66.33  ? 820  GLU A OE2 1 
ATOM   4041 N  N   . ASN A 1 558 ? -22.742 -51.538 -38.161 1.00 30.99  ? 821  ASN A N   1 
ATOM   4042 C  CA  . ASN A 1 558 ? -21.266 -51.325 -38.120 1.00 30.68  ? 821  ASN A CA  1 
ATOM   4043 C  C   . ASN A 1 558 ? -20.811 -50.968 -39.531 1.00 30.43  ? 821  ASN A C   1 
ATOM   4044 O  O   . ASN A 1 558 ? -20.702 -51.859 -40.375 1.00 30.63  ? 821  ASN A O   1 
ATOM   4045 C  CB  . ASN A 1 558 ? -20.594 -52.571 -37.577 1.00 30.61  ? 821  ASN A CB  1 
ATOM   4046 C  CG  . ASN A 1 558 ? -19.080 -52.516 -37.504 1.00 30.39  ? 821  ASN A CG  1 
ATOM   4047 O  OD1 . ASN A 1 558 ? -18.461 -51.556 -37.941 1.00 29.55  ? 821  ASN A OD1 1 
ATOM   4048 N  ND2 . ASN A 1 558 ? -18.492 -53.592 -36.995 1.00 27.77  ? 821  ASN A ND2 1 
ATOM   4049 N  N   . PRO A 1 559 ? -20.433 -49.703 -39.798 1.00 28.11  ? 822  PRO A N   1 
ATOM   4050 C  CA  . PRO A 1 559 ? -20.018 -49.306 -41.143 1.00 32.30  ? 822  PRO A CA  1 
ATOM   4051 C  C   . PRO A 1 559 ? -18.701 -49.936 -41.589 1.00 34.32  ? 822  PRO A C   1 
ATOM   4052 O  O   . PRO A 1 559 ? -18.414 -49.912 -42.741 1.00 35.29  ? 822  PRO A O   1 
ATOM   4053 C  CB  . PRO A 1 559 ? -19.921 -47.789 -41.082 1.00 37.34  ? 822  PRO A CB  1 
ATOM   4054 C  CG  . PRO A 1 559 ? -19.768 -47.456 -39.634 1.00 34.38  ? 822  PRO A CG  1 
ATOM   4055 C  CD  . PRO A 1 559 ? -20.451 -48.577 -38.858 1.00 32.85  ? 822  PRO A CD  1 
ATOM   4056 N  N   . TRP A 1 560 ? -17.952 -50.582 -40.681 1.00 31.34  ? 823  TRP A N   1 
ATOM   4057 C  CA  . TRP A 1 560 ? -16.691 -51.244 -41.076 1.00 31.21  ? 823  TRP A CA  1 
ATOM   4058 C  C   . TRP A 1 560 ? -16.913 -52.726 -41.398 1.00 36.53  ? 823  TRP A C   1 
ATOM   4059 O  O   . TRP A 1 560 ? -15.902 -53.377 -41.656 1.00 40.42  ? 823  TRP A O   1 
ATOM   4060 C  CB  . TRP A 1 560 ? -15.652 -51.039 -39.959 1.00 31.97  ? 823  TRP A CB  1 
ATOM   4061 C  CG  . TRP A 1 560 ? -15.212 -49.613 -39.824 1.00 29.54  ? 823  TRP A CG  1 
ATOM   4062 C  CD1 . TRP A 1 560 ? -14.247 -49.006 -40.567 1.00 27.25  ? 823  TRP A CD1 1 
ATOM   4063 C  CD2 . TRP A 1 560 ? -15.686 -48.632 -38.888 1.00 28.62  ? 823  TRP A CD2 1 
ATOM   4064 N  NE1 . TRP A 1 560 ? -14.108 -47.718 -40.171 1.00 29.47  ? 823  TRP A NE1 1 
ATOM   4065 C  CE2 . TRP A 1 560 ? -14.981 -47.452 -39.156 1.00 27.51  ? 823  TRP A CE2 1 
ATOM   4066 C  CE3 . TRP A 1 560 ? -16.636 -48.616 -37.869 1.00 27.73  ? 823  TRP A CE3 1 
ATOM   4067 C  CZ2 . TRP A 1 560 ? -15.184 -46.280 -38.442 1.00 26.83  ? 823  TRP A CZ2 1 
ATOM   4068 C  CZ3 . TRP A 1 560 ? -16.864 -47.449 -37.180 1.00 29.33  ? 823  TRP A CZ3 1 
ATOM   4069 C  CH2 . TRP A 1 560 ? -16.121 -46.298 -37.443 1.00 27.48  ? 823  TRP A CH2 1 
ATOM   4070 N  N   . MET A 1 561 ? -18.141 -53.258 -41.284 1.00 34.96  ? 824  MET A N   1 
ATOM   4071 C  CA  . MET A 1 561 ? -18.471 -54.700 -41.517 1.00 32.22  ? 824  MET A CA  1 
ATOM   4072 C  C   . MET A 1 561 ? -19.287 -54.761 -42.819 1.00 33.66  ? 824  MET A C   1 
ATOM   4073 O  O   . MET A 1 561 ? -20.431 -54.320 -42.819 1.00 34.33  ? 824  MET A O   1 
ATOM   4074 C  CB  . MET A 1 561 ? -19.278 -55.232 -40.315 1.00 30.65  ? 824  MET A CB  1 
ATOM   4075 C  CG  . MET A 1 561 ? -19.563 -56.750 -40.312 1.00 33.81  ? 824  MET A CG  1 
ATOM   4076 S  SD  . MET A 1 561 ? -18.062 -57.611 -40.138 1.00 47.31  ? 824  MET A SD  1 
ATOM   4077 C  CE  . MET A 1 561 ? -17.798 -57.377 -38.369 1.00 46.10  ? 824  MET A CE  1 
ATOM   4078 N  N   . GLU A 1 562 ? -18.711 -55.233 -43.918 1.00 35.71  ? 825  GLU A N   1 
ATOM   4079 C  CA  . GLU A 1 562 ? -19.426 -55.316 -45.221 1.00 44.41  ? 825  GLU A CA  1 
ATOM   4080 C  C   . GLU A 1 562 ? -20.430 -56.489 -45.239 1.00 37.50  ? 825  GLU A C   1 
ATOM   4081 O  O   . GLU A 1 562 ? -21.557 -56.288 -45.685 1.00 39.72  ? 825  GLU A O   1 
ATOM   4082 C  CB  . GLU A 1 562 ? -18.409 -55.410 -46.367 1.00 49.85  ? 825  GLU A CB  1 
ATOM   4083 C  CG  . GLU A 1 562 ? -19.051 -55.446 -47.749 1.00 64.16  ? 825  GLU A CG  1 
ATOM   4084 C  CD  . GLU A 1 562 ? -18.074 -55.506 -48.918 1.00 77.76  ? 825  GLU A CD  1 
ATOM   4085 O  OE1 . GLU A 1 562 ? -18.487 -55.152 -50.060 1.00 83.20  ? 825  GLU A OE1 1 
ATOM   4086 O  OE2 . GLU A 1 562 ? -16.900 -55.912 -48.694 1.00 88.47  ? 825  GLU A OE2 1 
ATOM   4087 N  N   . ASP A 1 563 ? -20.054 -57.684 -44.794 1.00 34.88  ? 826  ASP A N   1 
ATOM   4088 C  CA  . ASP A 1 563 ? -20.975 -58.846 -44.737 1.00 37.59  ? 826  ASP A CA  1 
ATOM   4089 C  C   . ASP A 1 563 ? -21.923 -58.687 -43.550 1.00 37.43  ? 826  ASP A C   1 
ATOM   4090 O  O   . ASP A 1 563 ? -21.421 -58.749 -42.404 1.00 36.68  ? 826  ASP A O   1 
ATOM   4091 C  CB  . ASP A 1 563 ? -20.132 -60.108 -44.620 1.00 33.95  ? 826  ASP A CB  1 
ATOM   4092 C  CG  . ASP A 1 563 ? -20.903 -61.402 -44.520 1.00 35.05  ? 826  ASP A CG  1 
ATOM   4093 O  OD1 . ASP A 1 563 ? -22.137 -61.346 -44.465 1.00 39.95  ? 826  ASP A OD1 1 
ATOM   4094 O  OD2 . ASP A 1 563 ? -20.232 -62.430 -44.375 1.00 43.91  ? 826  ASP A OD2 1 
ATOM   4095 N  N   . LYS A 1 564 ? -23.227 -58.532 -43.790 1.00 31.95  ? 827  LYS A N   1 
ATOM   4096 C  CA  . LYS A 1 564 ? -24.251 -58.344 -42.725 1.00 31.21  ? 827  LYS A CA  1 
ATOM   4097 C  C   . LYS A 1 564 ? -24.860 -59.672 -42.243 1.00 28.96  ? 827  LYS A C   1 
ATOM   4098 O  O   . LYS A 1 564 ? -25.938 -59.631 -41.593 1.00 33.06  ? 827  LYS A O   1 
ATOM   4099 C  CB  . LYS A 1 564 ? -25.303 -57.332 -43.193 1.00 32.56  ? 827  LYS A CB  1 
ATOM   4100 C  CG  . LYS A 1 564 ? -24.727 -55.993 -43.621 1.00 36.49  ? 827  LYS A CG  1 
ATOM   4101 C  CD  . LYS A 1 564 ? -23.858 -55.324 -42.585 1.00 30.53  ? 827  LYS A CD  1 
ATOM   4102 C  CE  . LYS A 1 564 ? -23.619 -53.871 -42.912 1.00 31.69  ? 827  LYS A CE  1 
ATOM   4103 N  NZ  . LYS A 1 564 ? -22.771 -53.245 -41.867 1.00 32.70  ? 827  LYS A NZ  1 
ATOM   4104 N  N   . THR A 1 565 ? -24.243 -60.810 -42.517 1.00 30.14  ? 828  THR A N   1 
ATOM   4105 C  CA  . THR A 1 565 ? -24.814 -62.109 -42.101 1.00 32.09  ? 828  THR A CA  1 
ATOM   4106 C  C   . THR A 1 565 ? -24.944 -62.105 -40.584 1.00 36.10  ? 828  THR A C   1 
ATOM   4107 O  O   . THR A 1 565 ? -23.939 -61.919 -39.918 1.00 32.98  ? 828  THR A O   1 
ATOM   4108 C  CB  . THR A 1 565 ? -23.934 -63.268 -42.555 1.00 36.79  ? 828  THR A CB  1 
ATOM   4109 O  OG1 . THR A 1 565 ? -23.734 -63.174 -43.967 1.00 39.44  ? 828  THR A OG1 1 
ATOM   4110 C  CG2 . THR A 1 565 ? -24.560 -64.596 -42.225 1.00 34.68  ? 828  THR A CG2 1 
ATOM   4111 N  N   . PRO A 1 566 ? -26.151 -62.297 -39.996 1.00 40.30  ? 829  PRO A N   1 
ATOM   4112 C  CA  . PRO A 1 566 ? -26.296 -62.269 -38.544 1.00 36.85  ? 829  PRO A CA  1 
ATOM   4113 C  C   . PRO A 1 566 ? -25.540 -63.428 -37.909 1.00 39.94  ? 829  PRO A C   1 
ATOM   4114 O  O   . PRO A 1 566 ? -25.371 -64.450 -38.525 1.00 33.96  ? 829  PRO A O   1 
ATOM   4115 C  CB  . PRO A 1 566 ? -27.823 -62.357 -38.340 1.00 46.18  ? 829  PRO A CB  1 
ATOM   4116 C  CG  . PRO A 1 566 ? -28.417 -61.914 -39.669 1.00 42.60  ? 829  PRO A CG  1 
ATOM   4117 C  CD  . PRO A 1 566 ? -27.444 -62.461 -40.678 1.00 43.83  ? 829  PRO A CD  1 
ATOM   4118 N  N   . VAL A 1 567 ? -25.148 -63.243 -36.651 1.00 34.92  ? 830  VAL A N   1 
ATOM   4119 C  CA  . VAL A 1 567 ? -24.587 -64.332 -35.826 1.00 36.04  ? 830  VAL A CA  1 
ATOM   4120 C  C   . VAL A 1 567 ? -25.780 -65.013 -35.139 1.00 35.32  ? 830  VAL A C   1 
ATOM   4121 O  O   . VAL A 1 567 ? -26.647 -64.301 -34.624 1.00 35.53  ? 830  VAL A O   1 
ATOM   4122 C  CB  . VAL A 1 567 ? -23.569 -63.700 -34.848 1.00 39.67  ? 830  VAL A CB  1 
ATOM   4123 C  CG1 . VAL A 1 567 ? -23.482 -64.437 -33.553 1.00 44.03  ? 830  VAL A CG1 1 
ATOM   4124 C  CG2 . VAL A 1 567 ? -22.216 -63.531 -35.510 1.00 38.95  ? 830  VAL A CG2 1 
ATOM   4125 N  N   . GLU A 1 568 ? -25.787 -66.343 -35.104 1.00 38.65  ? 831  GLU A N   1 
ATOM   4126 C  CA  . GLU A 1 568 ? -26.961 -67.140 -34.663 1.00 41.02  ? 831  GLU A CA  1 
ATOM   4127 C  C   . GLU A 1 568 ? -26.796 -67.509 -33.194 1.00 37.78  ? 831  GLU A C   1 
ATOM   4128 O  O   . GLU A 1 568 ? -27.796 -67.831 -32.556 1.00 34.62  ? 831  GLU A O   1 
ATOM   4129 C  CB  . GLU A 1 568 ? -27.082 -68.444 -35.454 1.00 47.09  ? 831  GLU A CB  1 
ATOM   4130 C  CG  . GLU A 1 568 ? -27.340 -68.248 -36.942 1.00 54.03  ? 831  GLU A CG  1 
ATOM   4131 C  CD  . GLU A 1 568 ? -28.681 -67.625 -37.295 1.00 53.19  ? 831  GLU A CD  1 
ATOM   4132 O  OE1 . GLU A 1 568 ? -29.653 -67.798 -36.544 1.00 61.56  ? 831  GLU A OE1 1 
ATOM   4133 O  OE2 . GLU A 1 568 ? -28.741 -66.972 -38.321 1.00 63.99  ? 831  GLU A OE2 1 
ATOM   4134 N  N   . SER A 1 569 ? -25.575 -67.480 -32.656 1.00 35.05  ? 832  SER A N   1 
ATOM   4135 C  CA  . SER A 1 569 ? -25.373 -67.852 -31.246 1.00 29.14  ? 832  SER A CA  1 
ATOM   4136 C  C   . SER A 1 569 ? -24.100 -67.219 -30.678 1.00 31.35  ? 832  SER A C   1 
ATOM   4137 O  O   . SER A 1 569 ? -23.218 -66.773 -31.422 1.00 30.33  ? 832  SER A O   1 
ATOM   4138 C  CB  . SER A 1 569 ? -25.294 -69.327 -31.083 1.00 34.56  ? 832  SER A CB  1 
ATOM   4139 O  OG  . SER A 1 569 ? -24.003 -69.787 -31.420 1.00 35.26  ? 832  SER A OG  1 
ATOM   4140 N  N   . TRP A 1 570 ? -24.006 -67.219 -29.370 1.00 30.32  ? 833  TRP A N   1 
ATOM   4141 C  CA  . TRP A 1 570 ? -22.823 -66.608 -28.698 1.00 32.03  ? 833  TRP A CA  1 
ATOM   4142 C  C   . TRP A 1 570 ? -21.534 -67.403 -29.026 1.00 33.14  ? 833  TRP A C   1 
ATOM   4143 O  O   . TRP A 1 570 ? -20.480 -66.832 -29.010 1.00 30.36  ? 833  TRP A O   1 
ATOM   4144 C  CB  . TRP A 1 570 ? -23.084 -66.443 -27.194 1.00 28.37  ? 833  TRP A CB  1 
ATOM   4145 C  CG  . TRP A 1 570 ? -23.933 -65.267 -26.833 1.00 31.23  ? 833  TRP A CG  1 
ATOM   4146 C  CD1 . TRP A 1 570 ? -25.259 -65.290 -26.519 1.00 31.26  ? 833  TRP A CD1 1 
ATOM   4147 C  CD2 . TRP A 1 570 ? -23.511 -63.888 -26.716 1.00 29.64  ? 833  TRP A CD2 1 
ATOM   4148 N  NE1 . TRP A 1 570 ? -25.688 -64.015 -26.229 1.00 32.55  ? 833  TRP A NE1 1 
ATOM   4149 C  CE2 . TRP A 1 570 ? -24.647 -63.135 -26.361 1.00 28.86  ? 833  TRP A CE2 1 
ATOM   4150 C  CE3 . TRP A 1 570 ? -22.282 -63.201 -26.872 1.00 28.91  ? 833  TRP A CE3 1 
ATOM   4151 C  CZ2 . TRP A 1 570 ? -24.585 -61.764 -26.089 1.00 29.76  ? 833  TRP A CZ2 1 
ATOM   4152 C  CZ3 . TRP A 1 570 ? -22.224 -61.850 -26.634 1.00 25.58  ? 833  TRP A CZ3 1 
ATOM   4153 C  CH2 . TRP A 1 570 ? -23.381 -61.130 -26.297 1.00 30.58  ? 833  TRP A CH2 1 
ATOM   4154 N  N   . GLU A 1 571 ? -21.618 -68.691 -29.362 0.48 33.97  ? 834  GLU A N   1 
ATOM   4155 C  CA  . GLU A 1 571 ? -20.395 -69.509 -29.603 0.48 36.99  ? 834  GLU A CA  1 
ATOM   4156 C  C   . GLU A 1 571 ? -19.753 -69.116 -30.946 0.48 36.20  ? 834  GLU A C   1 
ATOM   4157 O  O   . GLU A 1 571 ? -18.550 -69.399 -31.105 0.48 36.09  ? 834  GLU A O   1 
ATOM   4158 C  CB  . GLU A 1 571 ? -20.703 -71.000 -29.421 0.48 41.21  ? 834  GLU A CB  1 
ATOM   4159 C  CG  . GLU A 1 571 ? -20.868 -71.378 -27.950 0.48 46.77  ? 834  GLU A CG  1 
ATOM   4160 C  CD  . GLU A 1 571 ? -21.479 -72.741 -27.644 0.48 52.75  ? 834  GLU A CD  1 
ATOM   4161 O  OE1 . GLU A 1 571 ? -21.087 -73.738 -28.295 0.48 59.17  ? 834  GLU A OE1 1 
ATOM   4162 O  OE2 . GLU A 1 571 ? -22.343 -72.808 -26.741 0.48 55.24  ? 834  GLU A OE2 1 
ATOM   4163 N  N   . GLU A 1 572 ? -20.462 -68.404 -31.832 1.00 34.29  ? 835  GLU A N   1 
ATOM   4164 C  CA  . GLU A 1 572 ? -19.825 -67.779 -33.027 1.00 36.84  ? 835  GLU A CA  1 
ATOM   4165 C  C   . GLU A 1 572 ? -18.985 -66.534 -32.653 1.00 30.95  ? 835  GLU A C   1 
ATOM   4166 O  O   . GLU A 1 572 ? -18.282 -66.012 -33.531 1.00 31.70  ? 835  GLU A O   1 
ATOM   4167 C  CB  . GLU A 1 572 ? -20.843 -67.261 -34.050 1.00 37.71  ? 835  GLU A CB  1 
ATOM   4168 C  CG  . GLU A 1 572 ? -21.515 -68.318 -34.921 1.00 45.26  ? 835  GLU A CG  1 
ATOM   4169 C  CD  . GLU A 1 572 ? -22.601 -67.716 -35.842 1.00 45.23  ? 835  GLU A CD  1 
ATOM   4170 O  OE1 . GLU A 1 572 ? -22.277 -66.881 -36.714 1.00 46.66  ? 835  GLU A OE1 1 
ATOM   4171 O  OE2 . GLU A 1 572 ? -23.779 -68.057 -35.674 1.00 45.54  ? 835  GLU A OE2 1 
ATOM   4172 N  N   . ILE A 1 573 ? -19.138 -65.980 -31.457 1.00 27.15  ? 836  ILE A N   1 
ATOM   4173 C  CA  . ILE A 1 573 ? -18.518 -64.679 -31.098 1.00 26.62  ? 836  ILE A CA  1 
ATOM   4174 C  C   . ILE A 1 573 ? -17.213 -65.019 -30.372 1.00 27.72  ? 836  ILE A C   1 
ATOM   4175 O  O   . ILE A 1 573 ? -17.202 -65.765 -29.381 1.00 24.07  ? 836  ILE A O   1 
ATOM   4176 C  CB  . ILE A 1 573 ? -19.485 -63.827 -30.275 1.00 26.68  ? 836  ILE A CB  1 
ATOM   4177 C  CG1 . ILE A 1 573 ? -20.758 -63.487 -31.064 1.00 24.18  ? 836  ILE A CG1 1 
ATOM   4178 C  CG2 . ILE A 1 573 ? -18.803 -62.550 -29.760 1.00 29.47  ? 836  ILE A CG2 1 
ATOM   4179 C  CD1 . ILE A 1 573 ? -21.842 -62.825 -30.229 1.00 25.18  ? 836  ILE A CD1 1 
ATOM   4180 N  N   . PRO A 1 574 ? -16.075 -64.543 -30.891 1.00 25.85  ? 837  PRO A N   1 
ATOM   4181 C  CA  . PRO A 1 574 ? -14.755 -64.979 -30.401 1.00 26.26  ? 837  PRO A CA  1 
ATOM   4182 C  C   . PRO A 1 574 ? -14.300 -64.286 -29.099 1.00 26.57  ? 837  PRO A C   1 
ATOM   4183 O  O   . PRO A 1 574 ? -14.821 -63.267 -28.667 1.00 22.53  ? 837  PRO A O   1 
ATOM   4184 C  CB  . PRO A 1 574 ? -13.873 -64.591 -31.590 1.00 27.81  ? 837  PRO A CB  1 
ATOM   4185 C  CG  . PRO A 1 574 ? -14.492 -63.287 -32.071 1.00 28.26  ? 837  PRO A CG  1 
ATOM   4186 C  CD  . PRO A 1 574 ? -15.983 -63.581 -31.991 1.00 25.84  ? 837  PRO A CD  1 
ATOM   4187 N  N   . TYR A 1 575 ? -13.248 -64.856 -28.534 1.00 26.12  ? 838  TYR A N   1 
ATOM   4188 C  CA  . TYR A 1 575 ? -12.433 -64.297 -27.441 1.00 23.28  ? 838  TYR A CA  1 
ATOM   4189 C  C   . TYR A 1 575 ? -11.073 -63.837 -27.980 1.00 25.40  ? 838  TYR A C   1 
ATOM   4190 O  O   . TYR A 1 575 ? -10.590 -64.353 -29.013 1.00 27.16  ? 838  TYR A O   1 
ATOM   4191 C  CB  . TYR A 1 575 ? -12.217 -65.400 -26.415 1.00 22.86  ? 838  TYR A CB  1 
ATOM   4192 C  CG  . TYR A 1 575 ? -13.468 -65.891 -25.715 1.00 23.98  ? 838  TYR A CG  1 
ATOM   4193 C  CD1 . TYR A 1 575 ? -14.114 -65.120 -24.763 1.00 22.96  ? 838  TYR A CD1 1 
ATOM   4194 C  CD2 . TYR A 1 575 ? -13.971 -67.158 -25.945 1.00 30.10  ? 838  TYR A CD2 1 
ATOM   4195 C  CE1 . TYR A 1 575 ? -15.229 -65.586 -24.063 1.00 26.53  ? 838  TYR A CE1 1 
ATOM   4196 C  CE2 . TYR A 1 575 ? -15.048 -67.663 -25.223 1.00 31.79  ? 838  TYR A CE2 1 
ATOM   4197 C  CZ  . TYR A 1 575 ? -15.709 -66.856 -24.301 1.00 29.71  ? 838  TYR A CZ  1 
ATOM   4198 O  OH  . TYR A 1 575 ? -16.826 -67.288 -23.636 1.00 31.32  ? 838  TYR A OH  1 
ATOM   4199 N  N   . LEU A 1 576 ? -10.380 -62.998 -27.221 1.00 23.38  ? 839  LEU A N   1 
ATOM   4200 C  CA  . LEU A 1 576 ? -8.930  -62.795 -27.369 1.00 20.60  ? 839  LEU A CA  1 
ATOM   4201 C  C   . LEU A 1 576 ? -8.246  -64.151 -27.270 1.00 20.63  ? 839  LEU A C   1 
ATOM   4202 O  O   . LEU A 1 576 ? -8.821  -65.099 -26.630 1.00 21.84  ? 839  LEU A O   1 
ATOM   4203 C  CB  . LEU A 1 576 ? -8.453  -61.897 -26.221 1.00 21.97  ? 839  LEU A CB  1 
ATOM   4204 C  CG  . LEU A 1 576 ? -9.023  -60.485 -26.115 1.00 20.28  ? 839  LEU A CG  1 
ATOM   4205 C  CD1 . LEU A 1 576 ? -8.355  -59.737 -24.971 1.00 24.40  ? 839  LEU A CD1 1 
ATOM   4206 C  CD2 . LEU A 1 576 ? -8.848  -59.709 -27.400 1.00 24.09  ? 839  LEU A CD2 1 
ATOM   4207 N  N   . GLY A 1 577 ? -7.040  -64.286 -27.804 1.00 24.10  ? 840  GLY A N   1 
ATOM   4208 C  CA  . GLY A 1 577 ? -6.200  -65.465 -27.469 1.00 22.35  ? 840  GLY A CA  1 
ATOM   4209 C  C   . GLY A 1 577 ? -6.079  -65.635 -25.943 1.00 21.18  ? 840  GLY A C   1 
ATOM   4210 O  O   . GLY A 1 577 ? -6.159  -64.642 -25.159 1.00 21.47  ? 840  GLY A O   1 
ATOM   4211 N  N   . LYS A 1 578 ? -5.877  -66.868 -25.488 0.48 22.05  ? 841  LYS A N   1 
ATOM   4212 C  CA  . LYS A 1 578 ? -5.767  -67.199 -24.036 0.48 22.38  ? 841  LYS A CA  1 
ATOM   4213 C  C   . LYS A 1 578 ? -4.621  -66.413 -23.379 0.48 22.24  ? 841  LYS A C   1 
ATOM   4214 O  O   . LYS A 1 578 ? -4.787  -65.972 -22.235 0.48 20.20  ? 841  LYS A O   1 
ATOM   4215 C  CB  . LYS A 1 578 ? -5.539  -68.697 -23.859 0.48 23.81  ? 841  LYS A CB  1 
ATOM   4216 C  CG  . LYS A 1 578 ? -6.716  -69.578 -24.241 0.48 24.77  ? 841  LYS A CG  1 
ATOM   4217 C  CD  . LYS A 1 578 ? -6.517  -71.029 -23.837 0.48 27.55  ? 841  LYS A CD  1 
ATOM   4218 C  CE  . LYS A 1 578 ? -6.181  -71.950 -24.986 0.48 28.39  ? 841  LYS A CE  1 
ATOM   4219 N  NZ  . LYS A 1 578 ? -4.860  -71.639 -25.554 0.48 27.65  ? 841  LYS A NZ  1 
ATOM   4220 N  N   . ARG A 1 579 ? -3.481  -66.285 -24.058 1.00 22.44  ? 842  ARG A N   1 
ATOM   4221 C  CA  . ARG A 1 579 ? -2.320  -65.552 -23.523 1.00 21.76  ? 842  ARG A CA  1 
ATOM   4222 C  C   . ARG A 1 579 ? -2.654  -64.055 -23.495 1.00 21.79  ? 842  ARG A C   1 
ATOM   4223 O  O   . ARG A 1 579 ? -2.324  -63.376 -22.507 1.00 21.57  ? 842  ARG A O   1 
ATOM   4224 C  CB  . ARG A 1 579 ? -1.036  -65.868 -24.305 1.00 22.50  ? 842  ARG A CB  1 
ATOM   4225 C  CG  . ARG A 1 579 ? 0.187   -65.386 -23.558 1.00 24.33  ? 842  ARG A CG  1 
ATOM   4226 C  CD  . ARG A 1 579 ? 1.495   -65.613 -24.321 1.00 25.38  ? 842  ARG A CD  1 
ATOM   4227 N  NE  . ARG A 1 579 ? 1.636   -67.050 -24.490 1.00 26.14  ? 842  ARG A NE  1 
ATOM   4228 C  CZ  . ARG A 1 579 ? 2.111   -67.853 -23.597 1.00 29.92  ? 842  ARG A CZ  1 
ATOM   4229 N  NH1 . ARG A 1 579 ? 2.187   -69.136 -23.869 1.00 35.37  ? 842  ARG A NH1 1 
ATOM   4230 N  NH2 . ARG A 1 579 ? 2.586   -67.376 -22.467 1.00 28.87  ? 842  ARG A NH2 1 
ATOM   4231 N  N   . GLU A 1 580 ? -3.237  -63.535 -24.548 1.00 21.13  ? 843  GLU A N   1 
ATOM   4232 C  CA  . GLU A 1 580 ? -3.638  -62.091 -24.615 1.00 23.53  ? 843  GLU A CA  1 
ATOM   4233 C  C   . GLU A 1 580 ? -4.634  -61.769 -23.493 1.00 23.08  ? 843  GLU A C   1 
ATOM   4234 O  O   . GLU A 1 580 ? -4.546  -60.678 -22.886 1.00 20.37  ? 843  GLU A O   1 
ATOM   4235 C  CB  . GLU A 1 580 ? -4.279  -61.742 -25.948 1.00 26.17  ? 843  GLU A CB  1 
ATOM   4236 C  CG  . GLU A 1 580 ? -3.439  -62.040 -27.126 1.00 28.93  ? 843  GLU A CG  1 
ATOM   4237 C  CD  . GLU A 1 580 ? -4.183  -61.642 -28.386 1.00 39.34  ? 843  GLU A CD  1 
ATOM   4238 O  OE1 . GLU A 1 580 ? -5.236  -62.306 -28.749 1.00 34.05  ? 843  GLU A OE1 1 
ATOM   4239 O  OE2 . GLU A 1 580 ? -3.806  -60.589 -28.929 1.00 39.61  ? 843  GLU A OE2 1 
ATOM   4240 N  N   . ASP A 1 581 ? -5.543  -62.670 -23.192 1.00 20.07  ? 844  ASP A N   1 
ATOM   4241 C  CA  . ASP A 1 581 ? -6.580  -62.481 -22.130 1.00 19.58  ? 844  ASP A CA  1 
ATOM   4242 C  C   . ASP A 1 581 ? -5.873  -62.404 -20.774 1.00 19.93  ? 844  ASP A C   1 
ATOM   4243 O  O   . ASP A 1 581 ? -6.165  -61.512 -19.954 1.00 21.33  ? 844  ASP A O   1 
ATOM   4244 C  CB  . ASP A 1 581 ? -7.608  -63.622 -22.228 1.00 22.55  ? 844  ASP A CB  1 
ATOM   4245 C  CG  . ASP A 1 581 ? -9.035  -63.307 -21.736 1.00 24.24  ? 844  ASP A CG  1 
ATOM   4246 O  OD1 . ASP A 1 581 ? -9.247  -62.274 -21.098 1.00 20.96  ? 844  ASP A OD1 1 
ATOM   4247 O  OD2 . ASP A 1 581 ? -9.934  -64.145 -21.998 1.00 21.69  ? 844  ASP A OD2 1 
ATOM   4248 N  N   . GLN A 1 582 ? -4.872  -63.292 -20.542 1.00 20.27  ? 845  GLN A N   1 
ATOM   4249 C  CA  . GLN A 1 582 ? -4.063  -63.215 -19.291 1.00 20.07  ? 845  GLN A CA  1 
ATOM   4250 C  C   . GLN A 1 582 ? -3.306  -61.865 -19.227 1.00 19.31  ? 845  GLN A C   1 
ATOM   4251 O  O   . GLN A 1 582 ? -3.313  -61.239 -18.153 1.00 20.99  ? 845  GLN A O   1 
ATOM   4252 C  CB  . GLN A 1 582 ? -3.094  -64.404 -19.193 1.00 23.31  ? 845  GLN A CB  1 
ATOM   4253 C  CG  . GLN A 1 582 ? -3.786  -65.744 -19.043 1.00 25.26  ? 845  GLN A CG  1 
ATOM   4254 C  CD  . GLN A 1 582 ? -2.824  -66.911 -19.235 1.00 32.00  ? 845  GLN A CD  1 
ATOM   4255 O  OE1 . GLN A 1 582 ? -1.815  -66.824 -19.928 1.00 32.00  ? 845  GLN A OE1 1 
ATOM   4256 N  NE2 . GLN A 1 582 ? -3.181  -68.045 -18.661 1.00 28.71  ? 845  GLN A NE2 1 
ATOM   4257 N  N   . TRP A 1 583 ? -2.643  -61.458 -20.307 1.00 20.02  ? 846  TRP A N   1 
ATOM   4258 C  CA  . TRP A 1 583 ? -1.900  -60.193 -20.359 1.00 17.63  ? 846  TRP A CA  1 
ATOM   4259 C  C   . TRP A 1 583 ? -2.814  -59.037 -19.884 1.00 21.16  ? 846  TRP A C   1 
ATOM   4260 O  O   . TRP A 1 583 ? -2.349  -58.142 -19.180 1.00 20.66  ? 846  TRP A O   1 
ATOM   4261 C  CB  . TRP A 1 583 ? -1.345  -59.883 -21.735 1.00 20.61  ? 846  TRP A CB  1 
ATOM   4262 C  CG  . TRP A 1 583 ? -0.201  -60.787 -22.111 1.00 21.83  ? 846  TRP A CG  1 
ATOM   4263 C  CD1 . TRP A 1 583 ? 0.588   -61.497 -21.256 1.00 24.45  ? 846  TRP A CD1 1 
ATOM   4264 C  CD2 . TRP A 1 583 ? 0.357   -61.003 -23.412 1.00 22.97  ? 846  TRP A CD2 1 
ATOM   4265 N  NE1 . TRP A 1 583 ? 1.575   -62.145 -21.929 1.00 26.59  ? 846  TRP A NE1 1 
ATOM   4266 C  CE2 . TRP A 1 583 ? 1.426   -61.904 -23.255 1.00 24.38  ? 846  TRP A CE2 1 
ATOM   4267 C  CE3 . TRP A 1 583 ? 0.007   -60.605 -24.685 1.00 23.84  ? 846  TRP A CE3 1 
ATOM   4268 C  CZ2 . TRP A 1 583 ? 2.206   -62.325 -24.322 1.00 26.48  ? 846  TRP A CZ2 1 
ATOM   4269 C  CZ3 . TRP A 1 583 ? 0.735   -61.063 -25.755 1.00 24.69  ? 846  TRP A CZ3 1 
ATOM   4270 C  CH2 . TRP A 1 583 ? 1.783   -61.970 -25.570 1.00 24.40  ? 846  TRP A CH2 1 
ATOM   4271 N  N   . CYS A 1 584 ? -4.074  -59.042 -20.304 1.00 19.23  ? 847  CYS A N   1 
ATOM   4272 C  CA  . CYS A 1 584 ? -5.044  -57.958 -19.997 1.00 19.57  ? 847  CYS A CA  1 
ATOM   4273 C  C   . CYS A 1 584 ? -5.825  -58.234 -18.687 1.00 19.45  ? 847  CYS A C   1 
ATOM   4274 O  O   . CYS A 1 584 ? -6.865  -57.564 -18.447 1.00 19.86  ? 847  CYS A O   1 
ATOM   4275 C  CB  . CYS A 1 584 ? -5.916  -57.719 -21.208 1.00 21.54  ? 847  CYS A CB  1 
ATOM   4276 S  SG  . CYS A 1 584 ? -4.991  -56.941 -22.564 1.00 21.53  ? 847  CYS A SG  1 
ATOM   4277 N  N   . GLY A 1 585 ? -5.349  -59.173 -17.825 1.00 22.91  ? 848  GLY A N   1 
ATOM   4278 C  CA  . GLY A 1 585 ? -5.706  -59.366 -16.398 1.00 21.78  ? 848  GLY A CA  1 
ATOM   4279 C  C   . GLY A 1 585 ? -6.601  -60.577 -16.130 1.00 21.60  ? 848  GLY A C   1 
ATOM   4280 O  O   . GLY A 1 585 ? -7.098  -60.717 -15.014 1.00 24.54  ? 848  GLY A O   1 
ATOM   4281 N  N   . SER A 1 586 ? -6.880  -61.427 -17.106 1.00 23.17  ? 849  SER A N   1 
ATOM   4282 C  CA  . SER A 1 586 ? -7.760  -62.620 -16.895 1.00 22.50  ? 849  SER A CA  1 
ATOM   4283 C  C   . SER A 1 586 ? -7.136  -63.540 -15.827 1.00 24.76  ? 849  SER A C   1 
ATOM   4284 O  O   . SER A 1 586 ? -5.885  -63.688 -15.754 1.00 24.03  ? 849  SER A O   1 
ATOM   4285 C  CB  . SER A 1 586 ? -7.836  -63.421 -18.151 1.00 20.09  ? 849  SER A CB  1 
ATOM   4286 O  OG  . SER A 1 586 ? -8.757  -64.484 -18.010 1.00 22.13  ? 849  SER A OG  1 
ATOM   4287 N  N   . LEU A 1 587 ? -7.984  -64.244 -15.082 0.48 23.99  ? 850  LEU A N   1 
ATOM   4288 C  CA  . LEU A 1 587 ? -7.544  -65.285 -14.122 0.48 25.28  ? 850  LEU A CA  1 
ATOM   4289 C  C   . LEU A 1 587 ? -7.566  -66.675 -14.765 0.48 26.55  ? 850  LEU A C   1 
ATOM   4290 O  O   . LEU A 1 587 ? -7.220  -67.643 -14.038 0.48 27.12  ? 850  LEU A O   1 
ATOM   4291 C  CB  . LEU A 1 587 ? -8.435  -65.256 -12.877 0.48 25.23  ? 850  LEU A CB  1 
ATOM   4292 C  CG  . LEU A 1 587 ? -8.332  -64.016 -11.999 0.48 26.09  ? 850  LEU A CG  1 
ATOM   4293 C  CD1 . LEU A 1 587 ? -9.163  -64.204 -10.744 0.48 27.16  ? 850  LEU A CD1 1 
ATOM   4294 C  CD2 . LEU A 1 587 ? -6.881  -63.670 -11.647 0.48 27.23  ? 850  LEU A CD2 1 
ATOM   4295 N  N   . ILE A 1 588 ? -7.844  -66.772 -16.070 0.48 25.85  ? 851  ILE A N   1 
ATOM   4296 C  CA  . ILE A 1 588 ? -7.955  -68.107 -16.724 0.48 28.40  ? 851  ILE A CA  1 
ATOM   4297 C  C   . ILE A 1 588 ? -6.667  -68.897 -16.502 0.48 30.84  ? 851  ILE A C   1 
ATOM   4298 O  O   . ILE A 1 588 ? -5.594  -68.381 -16.844 0.48 27.87  ? 851  ILE A O   1 
ATOM   4299 C  CB  . ILE A 1 588 ? -8.292  -68.024 -18.225 0.48 30.28  ? 851  ILE A CB  1 
ATOM   4300 C  CG1 . ILE A 1 588 ? -7.436  -66.977 -18.942 0.48 29.72  ? 851  ILE A CG1 1 
ATOM   4301 C  CG2 . ILE A 1 588 ? -9.779  -67.780 -18.428 0.48 30.96  ? 851  ILE A CG2 1 
ATOM   4302 C  CD1 . ILE A 1 588 ? -7.416  -67.132 -20.441 0.48 28.37  ? 851  ILE A CD1 1 
ATOM   4303 N  N   . GLY A 1 589 ? -6.782  -70.047 -15.825 0.48 30.18  ? 852  GLY A N   1 
ATOM   4304 C  CA  . GLY A 1 589 ? -5.610  -70.901 -15.552 0.48 30.73  ? 852  GLY A CA  1 
ATOM   4305 C  C   . GLY A 1 589 ? -5.205  -70.886 -14.097 0.48 32.27  ? 852  GLY A C   1 
ATOM   4306 O  O   . GLY A 1 589 ? -4.170  -71.477 -13.780 0.48 33.11  ? 852  GLY A O   1 
ATOM   4307 N  N   . LEU A 1 590 ? -5.950  -70.175 -13.266 0.48 30.24  ? 853  LEU A N   1 
ATOM   4308 C  CA  . LEU A 1 590 ? -5.698  -70.204 -11.813 0.48 31.37  ? 853  LEU A CA  1 
ATOM   4309 C  C   . LEU A 1 590 ? -6.603  -71.301 -11.266 0.48 34.12  ? 853  LEU A C   1 
ATOM   4310 O  O   . LEU A 1 590 ? -7.696  -71.497 -11.828 0.48 30.52  ? 853  LEU A O   1 
ATOM   4311 C  CB  . LEU A 1 590 ? -6.019  -68.837 -11.217 0.48 31.30  ? 853  LEU A CB  1 
ATOM   4312 C  CG  . LEU A 1 590 ? -5.057  -67.728 -11.642 0.48 31.55  ? 853  LEU A CG  1 
ATOM   4313 C  CD1 . LEU A 1 590 ? -4.898  -66.695 -10.540 0.48 33.86  ? 853  LEU A CD1 1 
ATOM   4314 C  CD2 . LEU A 1 590 ? -3.701  -68.310 -12.020 0.48 31.60  ? 853  LEU A CD2 1 
ATOM   4315 N  N   . THR A 1 591 ? -6.164  -71.987 -10.216 1.00 33.99  ? 854  THR A N   1 
ATOM   4316 C  CA  . THR A 1 591 ? -6.966  -73.138 -9.759  1.00 37.16  ? 854  THR A CA  1 
ATOM   4317 C  C   . THR A 1 591 ? -8.356  -72.639 -9.420  1.00 32.34  ? 854  THR A C   1 
ATOM   4318 O  O   . THR A 1 591 ? -9.334  -73.245 -9.893  1.00 34.54  ? 854  THR A O   1 
ATOM   4319 C  CB  . THR A 1 591 ? -6.269  -73.823 -8.578  1.00 40.07  ? 854  THR A CB  1 
ATOM   4320 O  OG1 . THR A 1 591 ? -4.966  -74.187 -9.030  1.00 43.13  ? 854  THR A OG1 1 
ATOM   4321 C  CG2 . THR A 1 591 ? -7.029  -75.034 -8.090  1.00 46.89  ? 854  THR A CG2 1 
ATOM   4322 N  N   . SER A 1 592 ? -8.391  -71.525 -8.736  1.00 32.24  ? 855  SER A N   1 
ATOM   4323 C  CA  . SER A 1 592 ? -9.636  -70.927 -8.256  1.00 30.78  ? 855  SER A CA  1 
ATOM   4324 C  C   . SER A 1 592 ? -10.571 -70.470 -9.367  1.00 32.39  ? 855  SER A C   1 
ATOM   4325 O  O   . SER A 1 592 ? -11.769 -70.673 -9.192  1.00 31.03  ? 855  SER A O   1 
ATOM   4326 C  CB  . SER A 1 592 ? -9.207  -69.751 -7.447  1.00 34.80  ? 855  SER A CB  1 
ATOM   4327 O  OG  . SER A 1 592 ? -8.266  -68.986 -8.180  1.00 36.15  ? 855  SER A OG  1 
ATOM   4328 N  N   . ARG A 1 593 ? -10.049 -69.775 -10.379 0.48 30.15  ? 856  ARG A N   1 
ATOM   4329 C  CA  . ARG A 1 593 ? -10.901 -69.373 -11.530 0.48 29.43  ? 856  ARG A CA  1 
ATOM   4330 C  C   . ARG A 1 593 ? -11.601 -70.631 -12.042 0.48 29.92  ? 856  ARG A C   1 
ATOM   4331 O  O   . ARG A 1 593 ? -12.651 -70.488 -12.697 0.48 27.77  ? 856  ARG A O   1 
ATOM   4332 C  CB  . ARG A 1 593 ? -10.088 -68.667 -12.623 0.48 27.45  ? 856  ARG A CB  1 
ATOM   4333 C  CG  . ARG A 1 593 ? -10.907 -67.887 -13.643 0.48 26.71  ? 856  ARG A CG  1 
ATOM   4334 C  CD  . ARG A 1 593 ? -11.457 -68.733 -14.774 0.48 25.05  ? 856  ARG A CD  1 
ATOM   4335 N  NE  . ARG A 1 593 ? -12.164 -67.936 -15.763 0.48 25.84  ? 856  ARG A NE  1 
ATOM   4336 C  CZ  . ARG A 1 593 ? -12.957 -68.439 -16.702 0.48 26.61  ? 856  ARG A CZ  1 
ATOM   4337 N  NH1 . ARG A 1 593 ? -13.157 -69.743 -16.768 0.48 26.76  ? 856  ARG A NH1 1 
ATOM   4338 N  NH2 . ARG A 1 593 ? -13.553 -67.640 -17.567 0.48 24.63  ? 856  ARG A NH2 1 
ATOM   4339 N  N   . ALA A 1 594 ? -11.033 -71.809 -11.777 0.48 28.08  ? 857  ALA A N   1 
ATOM   4340 C  CA  . ALA A 1 594 ? -11.646 -73.033 -12.333 0.48 28.72  ? 857  ALA A CA  1 
ATOM   4341 C  C   . ALA A 1 594 ? -12.734 -73.465 -11.355 0.48 28.67  ? 857  ALA A C   1 
ATOM   4342 O  O   . ALA A 1 594 ? -13.782 -73.925 -11.814 0.48 28.14  ? 857  ALA A O   1 
ATOM   4343 C  CB  . ALA A 1 594 ? -10.613 -74.108 -12.562 0.48 30.12  ? 857  ALA A CB  1 
ATOM   4344 N  N   . THR A 1 595 ? -12.496 -73.242 -10.058 0.48 27.07  ? 858  THR A N   1 
ATOM   4345 C  CA  . THR A 1 595 ? -13.488 -73.607 -9.022  0.48 29.93  ? 858  THR A CA  1 
ATOM   4346 C  C   . THR A 1 595 ? -14.702 -72.708 -9.204  0.48 29.78  ? 858  THR A C   1 
ATOM   4347 O  O   . THR A 1 595 ? -15.822 -73.191 -9.037  0.48 28.35  ? 858  THR A O   1 
ATOM   4348 C  CB  . THR A 1 595 ? -12.901 -73.380 -7.622  0.48 30.85  ? 858  THR A CB  1 
ATOM   4349 O  OG1 . THR A 1 595 ? -11.684 -74.117 -7.510  0.48 31.94  ? 858  THR A OG1 1 
ATOM   4350 C  CG2 . THR A 1 595 ? -13.855 -73.774 -6.516  0.48 31.97  ? 858  THR A CG2 1 
ATOM   4351 N  N   . TRP A 1 596 ? -14.451 -71.444 -9.530  0.48 28.65  ? 859  TRP A N   1 
ATOM   4352 C  CA  . TRP A 1 596 ? -15.524 -70.434 -9.682  0.48 26.30  ? 859  TRP A CA  1 
ATOM   4353 C  C   . TRP A 1 596 ? -16.369 -70.729 -10.918 0.48 25.64  ? 859  TRP A C   1 
ATOM   4354 O  O   . TRP A 1 596 ? -17.611 -70.734 -10.780 0.48 25.83  ? 859  TRP A O   1 
ATOM   4355 C  CB  . TRP A 1 596 ? -14.835 -69.068 -9.728  0.48 27.01  ? 859  TRP A CB  1 
ATOM   4356 C  CG  . TRP A 1 596 ? -15.633 -67.913 -10.247 0.48 25.21  ? 859  TRP A CG  1 
ATOM   4357 C  CD1 . TRP A 1 596 ? -16.581 -67.208 -9.568  0.48 25.14  ? 859  TRP A CD1 1 
ATOM   4358 C  CD2 . TRP A 1 596 ? -15.477 -67.253 -11.516 0.48 25.49  ? 859  TRP A CD2 1 
ATOM   4359 N  NE1 . TRP A 1 596 ? -17.053 -66.181 -10.338 0.48 25.00  ? 859  TRP A NE1 1 
ATOM   4360 C  CE2 . TRP A 1 596 ? -16.396 -66.184 -11.539 0.48 24.79  ? 859  TRP A CE2 1 
ATOM   4361 C  CE3 . TRP A 1 596 ? -14.667 -67.461 -12.637 0.48 23.58  ? 859  TRP A CE3 1 
ATOM   4362 C  CZ2 . TRP A 1 596 ? -16.528 -65.338 -12.637 0.48 24.28  ? 859  TRP A CZ2 1 
ATOM   4363 C  CZ3 . TRP A 1 596 ? -14.799 -66.625 -13.722 0.48 23.91  ? 859  TRP A CZ3 1 
ATOM   4364 C  CH2 . TRP A 1 596 ? -15.720 -65.580 -13.721 0.48 24.61  ? 859  TRP A CH2 1 
ATOM   4365 N  N   . ALA A 1 597 ? -15.752 -70.972 -12.067 1.00 24.62  ? 860  ALA A N   1 
ATOM   4366 C  CA  . ALA A 1 597 ? -16.506 -71.372 -13.281 1.00 25.10  ? 860  ALA A CA  1 
ATOM   4367 C  C   . ALA A 1 597 ? -17.249 -72.705 -13.065 1.00 30.29  ? 860  ALA A C   1 
ATOM   4368 O  O   . ALA A 1 597 ? -18.406 -72.787 -13.509 1.00 28.29  ? 860  ALA A O   1 
ATOM   4369 C  CB  . ALA A 1 597 ? -15.679 -71.416 -14.554 1.00 25.24  ? 860  ALA A CB  1 
ATOM   4370 N  N   . LYS A 1 598 ? -16.641 -73.699 -12.413 1.00 29.43  ? 861  LYS A N   1 
ATOM   4371 C  CA  . LYS A 1 598 ? -17.249 -75.036 -12.193 1.00 34.52  ? 861  LYS A CA  1 
ATOM   4372 C  C   . LYS A 1 598 ? -18.503 -74.937 -11.319 1.00 29.16  ? 861  LYS A C   1 
ATOM   4373 O  O   . LYS A 1 598 ? -19.520 -75.574 -11.656 1.00 32.30  ? 861  LYS A O   1 
ATOM   4374 C  CB  . LYS A 1 598 ? -16.255 -75.960 -11.483 1.00 38.47  ? 861  LYS A CB  1 
ATOM   4375 C  CG  . LYS A 1 598 ? -16.636 -77.449 -11.475 1.00 47.20  ? 861  LYS A CG  1 
ATOM   4376 C  CD  . LYS A 1 598 ? -15.801 -78.282 -10.477 1.00 55.47  ? 861  LYS A CD  1 
ATOM   4377 C  CE  . LYS A 1 598 ? -15.807 -79.775 -10.754 1.00 69.45  ? 861  LYS A CE  1 
ATOM   4378 N  NZ  . LYS A 1 598 ? -17.110 -80.262 -11.286 1.00 67.19  ? 861  LYS A NZ  1 
ATOM   4379 N  N   . ASN A 1 599 ? -18.453 -74.160 -10.257 1.00 29.64  ? 862  ASN A N   1 
ATOM   4380 C  CA  . ASN A 1 599 ? -19.529 -74.044 -9.255  1.00 30.51  ? 862  ASN A CA  1 
ATOM   4381 C  C   . ASN A 1 599 ? -20.406 -72.810 -9.503  1.00 24.92  ? 862  ASN A C   1 
ATOM   4382 O  O   . ASN A 1 599 ? -21.118 -72.389 -8.577  1.00 27.19  ? 862  ASN A O   1 
ATOM   4383 C  CB  . ASN A 1 599 ? -18.903 -73.962 -7.864  1.00 29.12  ? 862  ASN A CB  1 
ATOM   4384 C  CG  . ASN A 1 599 ? -18.156 -75.231 -7.530  1.00 36.19  ? 862  ASN A CG  1 
ATOM   4385 O  OD1 . ASN A 1 599 ? -18.621 -76.309 -7.851  1.00 40.37  ? 862  ASN A OD1 1 
ATOM   4386 N  ND2 . ASN A 1 599 ? -17.057 -75.097 -6.835  1.00 42.66  ? 862  ASN A ND2 1 
ATOM   4387 N  N   . ILE A 1 600 ? -20.415 -72.231 -10.694 1.00 26.64  ? 863  ILE A N   1 
ATOM   4388 C  CA  . ILE A 1 600 ? -21.117 -70.912 -10.835 1.00 24.90  ? 863  ILE A CA  1 
ATOM   4389 C  C   . ILE A 1 600 ? -22.639 -71.010 -10.512 1.00 28.13  ? 863  ILE A C   1 
ATOM   4390 O  O   . ILE A 1 600 ? -23.221 -70.041 -10.065 1.00 24.66  ? 863  ILE A O   1 
ATOM   4391 C  CB  . ILE A 1 600 ? -20.842 -70.317 -12.212 1.00 22.87  ? 863  ILE A CB  1 
ATOM   4392 C  CG1 . ILE A 1 600 ? -21.241 -68.844 -12.271 1.00 25.94  ? 863  ILE A CG1 1 
ATOM   4393 C  CG2 . ILE A 1 600 ? -21.552 -71.115 -13.337 1.00 26.55  ? 863  ILE A CG2 1 
ATOM   4394 C  CD1 . ILE A 1 600 ? -20.371 -67.964 -11.558 1.00 23.42  ? 863  ILE A CD1 1 
ATOM   4395 N  N   A GLN A 1 601 ? -23.280 -72.164 -10.757 0.23 27.97  ? 864  GLN A N   1 
ATOM   4396 N  N   B GLN A 1 601 ? -23.272 -72.169 -10.752 0.23 27.80  ? 864  GLN A N   1 
ATOM   4397 C  CA  A GLN A 1 601 ? -24.745 -72.297 -10.512 0.23 28.63  ? 864  GLN A CA  1 
ATOM   4398 C  CA  B GLN A 1 601 ? -24.735 -72.315 -10.515 0.23 28.38  ? 864  GLN A CA  1 
ATOM   4399 C  C   A GLN A 1 601 ? -25.019 -72.155 -9.005  0.23 26.82  ? 864  GLN A C   1 
ATOM   4400 C  C   B GLN A 1 601 ? -25.017 -72.162 -9.010  0.23 26.68  ? 864  GLN A C   1 
ATOM   4401 O  O   A GLN A 1 601 ? -26.092 -71.626 -8.653  0.23 26.83  ? 864  GLN A O   1 
ATOM   4402 O  O   B GLN A 1 601 ? -26.092 -71.631 -8.665  0.23 26.76  ? 864  GLN A O   1 
ATOM   4403 C  CB  A GLN A 1 601 ? -25.302 -73.588 -11.118 0.23 28.74  ? 864  GLN A CB  1 
ATOM   4404 C  CB  B GLN A 1 601 ? -25.268 -73.617 -11.119 0.23 28.24  ? 864  GLN A CB  1 
ATOM   4405 C  CG  A GLN A 1 601 ? -25.325 -73.585 -12.641 0.23 29.97  ? 864  GLN A CG  1 
ATOM   4406 C  CG  B GLN A 1 601 ? -26.788 -73.661 -11.210 0.23 29.72  ? 864  GLN A CG  1 
ATOM   4407 C  CD  A GLN A 1 601 ? -26.323 -72.631 -13.256 0.23 31.38  ? 864  GLN A CD  1 
ATOM   4408 C  CD  B GLN A 1 601 ? -27.378 -72.448 -11.886 0.23 29.12  ? 864  GLN A CD  1 
ATOM   4409 O  OE1 A GLN A 1 601 ? -27.239 -72.139 -12.603 0.23 34.07  ? 864  GLN A OE1 1 
ATOM   4410 O  OE1 B GLN A 1 601 ? -27.088 -72.152 -13.048 0.23 29.48  ? 864  GLN A OE1 1 
ATOM   4411 N  NE2 A GLN A 1 601 ? -26.175 -72.397 -14.551 0.23 32.81  ? 864  GLN A NE2 1 
ATOM   4412 N  NE2 B GLN A 1 601 ? -28.234 -71.745 -11.161 0.23 29.37  ? 864  GLN A NE2 1 
ATOM   4413 N  N   . THR A 1 602 ? -24.078 -72.560 -8.148  1.00 27.01  ? 865  THR A N   1 
ATOM   4414 C  CA  . THR A 1 602 ? -24.172 -72.349 -6.674  1.00 27.71  ? 865  THR A CA  1 
ATOM   4415 C  C   . THR A 1 602 ? -24.144 -70.860 -6.330  1.00 27.97  ? 865  THR A C   1 
ATOM   4416 O  O   . THR A 1 602 ? -24.873 -70.423 -5.436  1.00 26.57  ? 865  THR A O   1 
ATOM   4417 C  CB  . THR A 1 602 ? -23.090 -73.153 -5.952  1.00 32.71  ? 865  THR A CB  1 
ATOM   4418 O  OG1 . THR A 1 602 ? -23.313 -74.509 -6.382  1.00 38.33  ? 865  THR A OG1 1 
ATOM   4419 C  CG2 . THR A 1 602 ? -23.188 -73.057 -4.453  1.00 34.62  ? 865  THR A CG2 1 
ATOM   4420 N  N   . ALA A 1 603 ? -23.345 -70.057 -7.025  1.00 26.31  ? 866  ALA A N   1 
ATOM   4421 C  CA  . ALA A 1 603 ? -23.248 -68.621 -6.720  1.00 24.26  ? 866  ALA A CA  1 
ATOM   4422 C  C   . ALA A 1 603 ? -24.511 -67.942 -7.215  1.00 22.70  ? 866  ALA A C   1 
ATOM   4423 O  O   . ALA A 1 603 ? -25.088 -67.128 -6.493  1.00 24.88  ? 866  ALA A O   1 
ATOM   4424 C  CB  . ALA A 1 603 ? -22.025 -68.029 -7.360  1.00 27.57  ? 866  ALA A CB  1 
ATOM   4425 N  N   . ILE A 1 604 ? -24.969 -68.345 -8.397  1.00 25.34  ? 867  ILE A N   1 
ATOM   4426 C  CA  . ILE A 1 604 ? -26.198 -67.764 -9.012  1.00 26.14  ? 867  ILE A CA  1 
ATOM   4427 C  C   . ILE A 1 604 ? -27.375 -68.031 -8.058  1.00 24.58  ? 867  ILE A C   1 
ATOM   4428 O  O   . ILE A 1 604 ? -28.144 -67.121 -7.776  1.00 22.01  ? 867  ILE A O   1 
ATOM   4429 C  CB  . ILE A 1 604 ? -26.425 -68.383 -10.401 1.00 26.03  ? 867  ILE A CB  1 
ATOM   4430 C  CG1 . ILE A 1 604 ? -25.437 -67.836 -11.420 1.00 25.30  ? 867  ILE A CG1 1 
ATOM   4431 C  CG2 . ILE A 1 604 ? -27.861 -68.153 -10.839 1.00 26.37  ? 867  ILE A CG2 1 
ATOM   4432 C  CD1 . ILE A 1 604 ? -25.356 -68.638 -12.714 1.00 28.44  ? 867  ILE A CD1 1 
ATOM   4433 N  N   . ASN A 1 605 ? -27.424 -69.248 -7.522  1.00 27.08  ? 868  ASN A N   1 
ATOM   4434 C  CA  . ASN A 1 605 ? -28.498 -69.696 -6.608  1.00 28.14  ? 868  ASN A CA  1 
ATOM   4435 C  C   . ASN A 1 605 ? -28.423 -68.942 -5.288  1.00 25.35  ? 868  ASN A C   1 
ATOM   4436 O  O   . ASN A 1 605 ? -29.476 -68.682 -4.728  1.00 24.65  ? 868  ASN A O   1 
ATOM   4437 C  CB  . ASN A 1 605 ? -28.474 -71.212 -6.413  1.00 30.81  ? 868  ASN A CB  1 
ATOM   4438 C  CG  . ASN A 1 605 ? -29.023 -71.960 -7.610  1.00 30.24  ? 868  ASN A CG  1 
ATOM   4439 O  OD1 . ASN A 1 605 ? -29.673 -71.412 -8.497  1.00 40.04  ? 868  ASN A OD1 1 
ATOM   4440 N  ND2 . ASN A 1 605 ? -28.689 -73.228 -7.682  1.00 37.53  ? 868  ASN A ND2 1 
ATOM   4441 N  N   . GLN A 1 606 ? -27.234 -68.624 -4.789  1.00 24.99  ? 869  GLN A N   1 
ATOM   4442 C  CA  . GLN A 1 606 ? -27.132 -67.832 -3.571  1.00 23.56  ? 869  GLN A CA  1 
ATOM   4443 C  C   . GLN A 1 606 ? -27.843 -66.497 -3.769  1.00 23.22  ? 869  GLN A C   1 
ATOM   4444 O  O   . GLN A 1 606 ? -28.529 -66.040 -2.839  1.00 26.87  ? 869  GLN A O   1 
ATOM   4445 C  CB  . GLN A 1 606 ? -25.674 -67.628 -3.152  1.00 25.29  ? 869  GLN A CB  1 
ATOM   4446 C  CG  . GLN A 1 606 ? -25.563 -66.777 -1.891  1.00 30.08  ? 869  GLN A CG  1 
ATOM   4447 C  CD  . GLN A 1 606 ? -24.152 -66.503 -1.405  1.00 33.48  ? 869  GLN A CD  1 
ATOM   4448 O  OE1 . GLN A 1 606 ? -23.214 -66.355 -2.209  1.00 31.59  ? 869  GLN A OE1 1 
ATOM   4449 N  NE2 . GLN A 1 606 ? -24.012 -66.407 -0.092  1.00 30.63  ? 869  GLN A NE2 1 
ATOM   4450 N  N   . VAL A 1 607 ? -27.540 -65.791 -4.848  1.00 22.45  ? 870  VAL A N   1 
ATOM   4451 C  CA  . VAL A 1 607 ? -28.109 -64.463 -5.160  1.00 22.15  ? 870  VAL A CA  1 
ATOM   4452 C  C   . VAL A 1 607 ? -29.626 -64.619 -5.434  1.00 21.80  ? 870  VAL A C   1 
ATOM   4453 O  O   . VAL A 1 607 ? -30.369 -63.865 -4.848  1.00 24.97  ? 870  VAL A O   1 
ATOM   4454 C  CB  . VAL A 1 607 ? -27.365 -63.811 -6.335  1.00 22.45  ? 870  VAL A CB  1 
ATOM   4455 C  CG1 . VAL A 1 607 ? -28.070 -62.574 -6.832  1.00 24.14  ? 870  VAL A CG1 1 
ATOM   4456 C  CG2 . VAL A 1 607 ? -25.927 -63.484 -5.924  1.00 22.07  ? 870  VAL A CG2 1 
ATOM   4457 N  N   . ARG A 1 608 ? -30.034 -65.632 -6.204  1.00 21.65  ? 871  ARG A N   1 
ATOM   4458 C  CA  . ARG A 1 608 ? -31.496 -65.876 -6.403  1.00 25.05  ? 871  ARG A CA  1 
ATOM   4459 C  C   . ARG A 1 608 ? -32.224 -66.034 -5.059  1.00 24.34  ? 871  ARG A C   1 
ATOM   4460 O  O   . ARG A 1 608 ? -33.354 -65.488 -4.925  1.00 24.84  ? 871  ARG A O   1 
ATOM   4461 C  CB  . ARG A 1 608 ? -31.718 -67.070 -7.318  1.00 23.21  ? 871  ARG A CB  1 
ATOM   4462 C  CG  . ARG A 1 608 ? -31.332 -66.820 -8.766  1.00 24.42  ? 871  ARG A CG  1 
ATOM   4463 C  CD  . ARG A 1 608 ? -31.745 -68.075 -9.544  1.00 24.84  ? 871  ARG A CD  1 
ATOM   4464 N  NE  . ARG A 1 608 ? -31.543 -67.901 -10.980 1.00 26.75  ? 871  ARG A NE  1 
ATOM   4465 C  CZ  . ARG A 1 608 ? -31.465 -68.897 -11.835 1.00 32.09  ? 871  ARG A CZ  1 
ATOM   4466 N  NH1 . ARG A 1 608 ? -31.532 -70.151 -11.415 1.00 38.90  ? 871  ARG A NH1 1 
ATOM   4467 N  NH2 . ARG A 1 608 ? -31.290 -68.661 -13.117 1.00 30.96  ? 871  ARG A NH2 1 
ATOM   4468 N  N   . SER A 1 609 ? -31.638 -66.790 -4.136  1.00 25.93  ? 872  SER A N   1 
ATOM   4469 C  CA  . SER A 1 609 ? -32.240 -67.047 -2.806  1.00 27.99  ? 872  SER A CA  1 
ATOM   4470 C  C   . SER A 1 609 ? -32.370 -65.720 -2.042  1.00 26.32  ? 872  SER A C   1 
ATOM   4471 O  O   . SER A 1 609 ? -33.279 -65.585 -1.243  1.00 25.00  ? 872  SER A O   1 
ATOM   4472 C  CB  . SER A 1 609 ? -31.480 -68.072 -2.038  1.00 25.44  ? 872  SER A CB  1 
ATOM   4473 O  OG  . SER A 1 609 ? -31.474 -69.358 -2.658  1.00 27.71  ? 872  SER A OG  1 
ATOM   4474 N  N   . LEU A 1 610 ? -31.380 -64.828 -2.095  1.00 24.03  ? 873  LEU A N   1 
ATOM   4475 C  CA  . LEU A 1 610 ? -31.506 -63.490 -1.482  1.00 24.25  ? 873  LEU A CA  1 
ATOM   4476 C  C   . LEU A 1 610 ? -32.638 -62.684 -2.129  1.00 24.35  ? 873  LEU A C   1 
ATOM   4477 O  O   . LEU A 1 610 ? -33.342 -61.982 -1.418  1.00 25.16  ? 873  LEU A O   1 
ATOM   4478 C  CB  . LEU A 1 610 ? -30.146 -62.762 -1.522  1.00 25.64  ? 873  LEU A CB  1 
ATOM   4479 C  CG  . LEU A 1 610 ? -29.031 -63.462 -0.725  1.00 25.13  ? 873  LEU A CG  1 
ATOM   4480 C  CD1 . LEU A 1 610 ? -27.663 -62.874 -1.035  1.00 26.93  ? 873  LEU A CD1 1 
ATOM   4481 C  CD2 . LEU A 1 610 ? -29.299 -63.430 0.776   1.00 25.13  ? 873  LEU A CD2 1 
ATOM   4482 N  N   . ILE A 1 611 ? -32.697 -62.615 -3.450  1.00 26.73  ? 874  ILE A N   1 
ATOM   4483 C  CA  . ILE A 1 611 ? -33.703 -61.742 -4.130  1.00 27.89  ? 874  ILE A CA  1 
ATOM   4484 C  C   . ILE A 1 611 ? -35.127 -62.313 -3.922  1.00 30.10  ? 874  ILE A C   1 
ATOM   4485 O  O   . ILE A 1 611 ? -36.035 -61.508 -3.666  1.00 29.57  ? 874  ILE A O   1 
ATOM   4486 C  CB  . ILE A 1 611 ? -33.313 -61.601 -5.611  1.00 27.06  ? 874  ILE A CB  1 
ATOM   4487 C  CG1 . ILE A 1 611 ? -32.016 -60.811 -5.703  1.00 25.57  ? 874  ILE A CG1 1 
ATOM   4488 C  CG2 . ILE A 1 611 ? -34.408 -60.909 -6.432  1.00 28.00  ? 874  ILE A CG2 1 
ATOM   4489 C  CD1 . ILE A 1 611 ? -31.465 -60.630 -7.051  1.00 27.06  ? 874  ILE A CD1 1 
ATOM   4490 N  N   . GLY A 1 612 ? -35.263 -63.628 -3.907  1.00 26.90  ? 875  GLY A N   1 
ATOM   4491 C  CA  . GLY A 1 612 ? -36.520 -64.338 -3.589  1.00 33.15  ? 875  GLY A CA  1 
ATOM   4492 C  C   . GLY A 1 612 ? -37.152 -65.004 -4.812  1.00 34.61  ? 875  GLY A C   1 
ATOM   4493 O  O   . GLY A 1 612 ? -36.495 -65.189 -5.849  1.00 28.81  ? 875  GLY A O   1 
ATOM   4494 N  N   . ASN A 1 613 ? -38.447 -65.323 -4.694  0.50 32.63  ? 876  ASN A N   1 
ATOM   4495 C  CA  . ASN A 1 613 ? -39.223 -66.115 -5.691  0.50 30.82  ? 876  ASN A CA  1 
ATOM   4496 C  C   . ASN A 1 613 ? -39.635 -65.195 -6.851  0.50 28.49  ? 876  ASN A C   1 
ATOM   4497 O  O   . ASN A 1 613 ? -40.665 -64.478 -6.740  0.50 25.62  ? 876  ASN A O   1 
ATOM   4498 C  CB  . ASN A 1 613 ? -40.428 -66.806 -5.041  0.50 34.28  ? 876  ASN A CB  1 
ATOM   4499 C  CG  . ASN A 1 613 ? -40.812 -68.093 -5.749  0.50 33.56  ? 876  ASN A CG  1 
ATOM   4500 O  OD1 . ASN A 1 613 ? -40.125 -68.518 -6.666  0.50 32.85  ? 876  ASN A OD1 1 
ATOM   4501 N  ND2 . ASN A 1 613 ? -41.902 -68.728 -5.328  0.50 34.30  ? 876  ASN A ND2 1 
ATOM   4502 N  N   . GLU A 1 614 ? -38.882 -65.254 -7.946  0.50 22.00  ? 877  GLU A N   1 
ATOM   4503 C  CA  . GLU A 1 614 ? -38.960 -64.287 -9.065  0.50 21.94  ? 877  GLU A CA  1 
ATOM   4504 C  C   . GLU A 1 614 ? -38.820 -65.081 -10.369 0.50 21.38  ? 877  GLU A C   1 
ATOM   4505 O  O   . GLU A 1 614 ? -38.437 -66.270 -10.297 0.50 21.96  ? 877  GLU A O   1 
ATOM   4506 C  CB  . GLU A 1 614 ? -37.869 -63.221 -8.895  0.50 21.23  ? 877  GLU A CB  1 
ATOM   4507 C  CG  . GLU A 1 614 ? -38.062 -62.339 -7.676  0.50 20.65  ? 877  GLU A CG  1 
ATOM   4508 C  CD  . GLU A 1 614 ? -39.291 -61.437 -7.675  0.50 21.18  ? 877  GLU A CD  1 
ATOM   4509 O  OE1 . GLU A 1 614 ? -39.884 -61.240 -8.738  0.50 21.42  ? 877  GLU A OE1 1 
ATOM   4510 O  OE2 . GLU A 1 614 ? -39.633 -60.917 -6.595  0.50 21.36  ? 877  GLU A OE2 1 
ATOM   4511 N  N   . GLU A 1 615 ? -39.139 -64.467 -11.512 0.50 25.46  ? 878  GLU A N   1 
ATOM   4512 C  CA  . GLU A 1 615 ? -38.930 -65.142 -12.818 0.50 27.41  ? 878  GLU A CA  1 
ATOM   4513 C  C   . GLU A 1 615 ? -37.482 -64.902 -13.252 0.50 28.43  ? 878  GLU A C   1 
ATOM   4514 O  O   . GLU A 1 615 ? -37.117 -63.725 -13.500 0.50 28.10  ? 878  GLU A O   1 
ATOM   4515 C  CB  . GLU A 1 615 ? -39.858 -64.667 -13.934 0.50 28.49  ? 878  GLU A CB  1 
ATOM   4516 C  CG  . GLU A 1 615 ? -39.491 -65.314 -15.264 0.50 30.58  ? 878  GLU A CG  1 
ATOM   4517 C  CD  . GLU A 1 615 ? -40.392 -64.999 -16.447 0.50 34.67  ? 878  GLU A CD  1 
ATOM   4518 O  OE1 . GLU A 1 615 ? -41.347 -64.229 -16.269 0.50 32.39  ? 878  GLU A OE1 1 
ATOM   4519 O  OE2 . GLU A 1 615 ? -40.135 -65.546 -17.548 0.50 39.36  ? 878  GLU A OE2 1 
ATOM   4520 N  N   . TYR A 1 616 ? -36.724 -65.991 -13.361 0.50 28.51  ? 879  TYR A N   1 
ATOM   4521 C  CA  . TYR A 1 616 ? -35.290 -66.016 -13.743 0.50 29.55  ? 879  TYR A CA  1 
ATOM   4522 C  C   . TYR A 1 616 ? -35.114 -66.810 -15.044 0.50 32.03  ? 879  TYR A C   1 
ATOM   4523 O  O   . TYR A 1 616 ? -35.962 -67.660 -15.351 0.50 29.79  ? 879  TYR A O   1 
ATOM   4524 C  CB  . TYR A 1 616 ? -34.476 -66.643 -12.611 0.50 28.35  ? 879  TYR A CB  1 
ATOM   4525 C  CG  . TYR A 1 616 ? -34.493 -65.894 -11.301 0.50 25.34  ? 879  TYR A CG  1 
ATOM   4526 C  CD1 . TYR A 1 616 ? -33.637 -64.830 -11.087 0.50 24.57  ? 879  TYR A CD1 1 
ATOM   4527 C  CD2 . TYR A 1 616 ? -35.345 -66.261 -10.269 0.50 25.21  ? 879  TYR A CD2 1 
ATOM   4528 C  CE1 . TYR A 1 616 ? -33.629 -64.143 -9.881  0.50 23.93  ? 879  TYR A CE1 1 
ATOM   4529 C  CE2 . TYR A 1 616 ? -35.342 -65.597 -9.050  0.50 22.56  ? 879  TYR A CE2 1 
ATOM   4530 C  CZ  . TYR A 1 616 ? -34.473 -64.538 -8.855  0.50 22.93  ? 879  TYR A CZ  1 
ATOM   4531 O  OH  . TYR A 1 616 ? -34.436 -63.847 -7.677  0.50 23.19  ? 879  TYR A OH  1 
ATOM   4532 N  N   . THR A 1 617 ? -34.056 -66.494 -15.802 1.00 33.77  ? 880  THR A N   1 
ATOM   4533 C  CA  . THR A 1 617 ? -33.613 -67.249 -17.010 1.00 35.05  ? 880  THR A CA  1 
ATOM   4534 C  C   . THR A 1 617 ? -32.178 -67.751 -16.751 1.00 33.79  ? 880  THR A C   1 
ATOM   4535 O  O   . THR A 1 617 ? -31.366 -66.985 -16.152 1.00 28.61  ? 880  THR A O   1 
ATOM   4536 C  CB  . THR A 1 617 ? -33.646 -66.335 -18.237 1.00 36.69  ? 880  THR A CB  1 
ATOM   4537 O  OG1 . THR A 1 617 ? -34.964 -65.796 -18.348 1.00 33.23  ? 880  THR A OG1 1 
ATOM   4538 C  CG2 . THR A 1 617 ? -33.278 -67.042 -19.535 1.00 33.95  ? 880  THR A CG2 1 
ATOM   4539 N  N   . ASP A 1 618 ? -31.869 -68.984 -17.159 1.00 31.49  ? 881  ASP A N   1 
ATOM   4540 C  CA  . ASP A 1 618 ? -30.487 -69.523 -17.126 1.00 37.36  ? 881  ASP A CA  1 
ATOM   4541 C  C   . ASP A 1 618 ? -29.767 -69.105 -18.416 1.00 34.71  ? 881  ASP A C   1 
ATOM   4542 O  O   . ASP A 1 618 ? -30.000 -69.734 -19.457 1.00 31.97  ? 881  ASP A O   1 
ATOM   4543 C  CB  . ASP A 1 618 ? -30.489 -71.042 -16.924 1.00 37.48  ? 881  ASP A CB  1 
ATOM   4544 C  CG  . ASP A 1 618 ? -29.088 -71.665 -16.872 1.00 42.81  ? 881  ASP A CG  1 
ATOM   4545 O  OD1 . ASP A 1 618 ? -28.072 -70.912 -16.739 1.00 32.77  ? 881  ASP A OD1 1 
ATOM   4546 O  OD2 . ASP A 1 618 ? -29.007 -72.912 -16.995 1.00 43.68  ? 881  ASP A OD2 1 
ATOM   4547 N  N   . TYR A 1 619 ? -28.845 -68.142 -18.367 1.00 32.07  ? 882  TYR A N   1 
ATOM   4548 C  CA  . TYR A 1 619 ? -28.060 -67.789 -19.583 1.00 29.47  ? 882  TYR A CA  1 
ATOM   4549 C  C   . TYR A 1 619 ? -26.765 -68.604 -19.686 1.00 31.81  ? 882  TYR A C   1 
ATOM   4550 O  O   . TYR A 1 619 ? -25.995 -68.364 -20.655 1.00 33.46  ? 882  TYR A O   1 
ATOM   4551 C  CB  . TYR A 1 619 ? -27.748 -66.295 -19.587 1.00 29.11  ? 882  TYR A CB  1 
ATOM   4552 C  CG  . TYR A 1 619 ? -28.970 -65.447 -19.725 1.00 32.12  ? 882  TYR A CG  1 
ATOM   4553 C  CD1 . TYR A 1 619 ? -29.642 -65.385 -20.939 1.00 35.52  ? 882  TYR A CD1 1 
ATOM   4554 C  CD2 . TYR A 1 619 ? -29.532 -64.812 -18.633 1.00 30.49  ? 882  TYR A CD2 1 
ATOM   4555 C  CE1 . TYR A 1 619 ? -30.794 -64.629 -21.094 1.00 34.50  ? 882  TYR A CE1 1 
ATOM   4556 C  CE2 . TYR A 1 619 ? -30.666 -64.021 -18.775 1.00 33.82  ? 882  TYR A CE2 1 
ATOM   4557 C  CZ  . TYR A 1 619 ? -31.307 -63.928 -20.004 1.00 36.15  ? 882  TYR A CZ  1 
ATOM   4558 O  OH  . TYR A 1 619 ? -32.431 -63.146 -20.109 1.00 38.72  ? 882  TYR A OH  1 
ATOM   4559 N  N   . MET A 1 620 ? -26.414 -69.451 -18.707 1.00 34.12  ? 883  MET A N   1 
ATOM   4560 C  CA  . MET A 1 620 ? -25.067 -70.095 -18.722 1.00 34.85  ? 883  MET A CA  1 
ATOM   4561 C  C   . MET A 1 620 ? -24.896 -71.063 -19.912 1.00 37.58  ? 883  MET A C   1 
ATOM   4562 O  O   . MET A 1 620 ? -23.795 -71.099 -20.480 1.00 41.36  ? 883  MET A O   1 
ATOM   4563 C  CB  . MET A 1 620 ? -24.665 -70.812 -17.432 1.00 31.98  ? 883  MET A CB  1 
ATOM   4564 C  CG  . MET A 1 620 ? -24.776 -69.976 -16.146 1.00 31.08  ? 883  MET A CG  1 
ATOM   4565 S  SD  . MET A 1 620 ? -24.003 -68.342 -16.284 1.00 32.27  ? 883  MET A SD  1 
ATOM   4566 C  CE  . MET A 1 620 ? -22.288 -68.814 -16.529 1.00 31.46  ? 883  MET A CE  1 
ATOM   4567 N  N   . PRO A 1 621 ? -25.906 -71.855 -20.357 1.00 41.27  ? 884  PRO A N   1 
ATOM   4568 C  CA  . PRO A 1 621 ? -25.729 -72.736 -21.524 1.00 46.70  ? 884  PRO A CA  1 
ATOM   4569 C  C   . PRO A 1 621 ? -25.583 -72.059 -22.903 1.00 47.30  ? 884  PRO A C   1 
ATOM   4570 O  O   . PRO A 1 621 ? -25.393 -72.810 -23.881 1.00 51.37  ? 884  PRO A O   1 
ATOM   4571 C  CB  . PRO A 1 621 ? -27.001 -73.631 -21.523 1.00 48.91  ? 884  PRO A CB  1 
ATOM   4572 C  CG  . PRO A 1 621 ? -27.604 -73.486 -20.124 1.00 51.07  ? 884  PRO A CG  1 
ATOM   4573 C  CD  . PRO A 1 621 ? -27.222 -72.071 -19.711 1.00 49.50  ? 884  PRO A CD  1 
ATOM   4574 N  N   . SER A 1 622 ? -25.602 -70.711 -22.991 1.00 45.61  ? 885  SER A N   1 
ATOM   4575 C  CA  . SER A 1 622 ? -25.098 -69.950 -24.179 1.00 46.47  ? 885  SER A CA  1 
ATOM   4576 C  C   . SER A 1 622 ? -23.580 -70.185 -24.329 1.00 57.79  ? 885  SER A C   1 
ATOM   4577 O  O   . SER A 1 622 ? -23.030 -69.906 -25.440 1.00 49.22  ? 885  SER A O   1 
ATOM   4578 C  CB  . SER A 1 622 ? -25.425 -68.458 -24.145 1.00 48.65  ? 885  SER A CB  1 
ATOM   4579 O  OG  . SER A 1 622 ? -24.850 -67.787 -23.021 1.00 37.43  ? 885  SER A OG  1 
ATOM   4580 N  N   . MET A 1 623 ? -22.922 -70.677 -23.263 1.00 46.64  ? 886  MET A N   1 
ATOM   4581 C  CA  . MET A 1 623 ? -21.469 -70.968 -23.272 1.00 54.69  ? 886  MET A CA  1 
ATOM   4582 C  C   . MET A 1 623 ? -21.291 -72.480 -23.440 1.00 58.66  ? 886  MET A C   1 
ATOM   4583 O  O   . MET A 1 623 ? -21.855 -73.198 -22.592 1.00 48.47  ? 886  MET A O   1 
ATOM   4584 C  CB  . MET A 1 623 ? -20.802 -70.522 -21.961 1.00 58.92  ? 886  MET A CB  1 
ATOM   4585 C  CG  . MET A 1 623 ? -21.356 -69.253 -21.360 1.00 56.51  ? 886  MET A CG  1 
ATOM   4586 S  SD  . MET A 1 623 ? -20.328 -68.649 -19.942 1.00 49.51  ? 886  MET A SD  1 
ATOM   4587 C  CE  . MET A 1 623 ? -19.074 -67.781 -20.845 1.00 44.96  ? 886  MET A CE  1 
ATOM   4588 N  N   . LYS A 1 624 ? -20.515 -72.914 -24.448 1.00 67.05  ? 887  LYS A N   1 
ATOM   4589 C  CA  . LYS A 1 624 ? -20.209 -74.340 -24.780 1.00 75.73  ? 887  LYS A CA  1 
ATOM   4590 C  C   . LYS A 1 624 ? -19.939 -75.198 -23.522 1.00 72.11  ? 887  LYS A C   1 
ATOM   4591 O  O   . LYS A 1 624 ? -20.425 -76.356 -23.480 1.00 67.26  ? 887  LYS A O   1 
ATOM   4592 C  CB  . LYS A 1 624 ? -19.002 -74.424 -25.730 1.00 82.89  ? 887  LYS A CB  1 
ATOM   4593 C  CG  . LYS A 1 624 ? -18.780 -75.804 -26.349 1.00 86.35  ? 887  LYS A CG  1 
ATOM   4594 C  CD  . LYS A 1 624 ? -17.820 -75.842 -27.532 1.00 91.46  ? 887  LYS A CD  1 
ATOM   4595 C  CE  . LYS A 1 624 ? -16.570 -76.669 -27.286 1.00 94.85  ? 887  LYS A CE  1 
ATOM   4596 N  NZ  . LYS A 1 624 ? -15.586 -75.965 -26.427 1.00 95.29  ? 887  LYS A NZ  1 
ATOM   4597 N  N   . ARG A 1 625 ? -19.171 -74.690 -22.548 1.00 74.83  ? 888  ARG A N   1 
ATOM   4598 C  CA  . ARG A 1 625 ? -18.706 -75.455 -21.349 1.00 77.48  ? 888  ARG A CA  1 
ATOM   4599 C  C   . ARG A 1 625 ? -19.875 -75.883 -20.428 1.00 80.22  ? 888  ARG A C   1 
ATOM   4600 O  O   . ARG A 1 625 ? -19.715 -76.899 -19.726 1.00 69.35  ? 888  ARG A O   1 
ATOM   4601 C  CB  . ARG A 1 625 ? -17.660 -74.635 -20.576 1.00 80.83  ? 888  ARG A CB  1 
ATOM   4602 C  CG  . ARG A 1 625 ? -18.192 -73.421 -19.813 1.00 76.91  ? 888  ARG A CG  1 
ATOM   4603 C  CD  . ARG A 1 625 ? -17.210 -72.968 -18.739 1.00 69.84  ? 888  ARG A CD  1 
ATOM   4604 N  NE  . ARG A 1 625 ? -17.070 -73.992 -17.703 1.00 70.94  ? 888  ARG A NE  1 
ATOM   4605 C  CZ  . ARG A 1 625 ? -15.966 -74.263 -16.999 1.00 64.32  ? 888  ARG A CZ  1 
ATOM   4606 N  NH1 . ARG A 1 625 ? -14.850 -73.570 -17.193 1.00 61.34  ? 888  ARG A NH1 1 
ATOM   4607 N  NH2 . ARG A 1 625 ? -15.999 -75.226 -16.083 1.00 48.62  ? 888  ARG A NH2 1 
ATOM   4608 N  N   . PHE A 1 626 ? -20.988 -75.128 -20.375 1.00 80.40  ? 889  PHE A N   1 
ATOM   4609 C  CA  . PHE A 1 626 ? -22.201 -75.428 -19.555 1.00 72.59  ? 889  PHE A CA  1 
ATOM   4610 C  C   . PHE A 1 626 ? -23.285 -76.011 -20.476 1.00 74.39  ? 889  PHE A C   1 
ATOM   4611 O  O   . PHE A 1 626 ? -24.440 -76.262 -20.062 1.00 64.16  ? 889  PHE A O   1 
ATOM   4612 C  CB  . PHE A 1 626 ? -22.690 -74.169 -18.822 1.00 63.48  ? 889  PHE A CB  1 
ATOM   4613 C  CG  . PHE A 1 626 ? -21.644 -73.470 -17.981 1.00 65.70  ? 889  PHE A CG  1 
ATOM   4614 C  CD1 . PHE A 1 626 ? -21.194 -74.032 -16.787 1.00 61.09  ? 889  PHE A CD1 1 
ATOM   4615 C  CD2 . PHE A 1 626 ? -21.097 -72.258 -18.388 1.00 56.25  ? 889  PHE A CD2 1 
ATOM   4616 C  CE1 . PHE A 1 626 ? -20.225 -73.396 -16.021 1.00 69.18  ? 889  PHE A CE1 1 
ATOM   4617 C  CE2 . PHE A 1 626 ? -20.129 -71.620 -17.621 1.00 62.71  ? 889  PHE A CE2 1 
ATOM   4618 C  CZ  . PHE A 1 626 ? -19.698 -72.184 -16.431 1.00 58.42  ? 889  PHE A CZ  1 
ATOM   4619 N  N   . ARG A 1 627 ? -22.929 -76.236 -21.735 1.00 80.06  ? 890  ARG A N   1 
ATOM   4620 C  CA  . ARG A 1 627 ? -23.876 -76.749 -22.749 1.00 103.46 ? 890  ARG A CA  1 
ATOM   4621 C  C   . ARG A 1 627 ? -23.708 -78.277 -22.859 1.00 117.70 ? 890  ARG A C   1 
ATOM   4622 O  O   . ARG A 1 627 ? -23.435 -78.773 -23.970 1.00 133.76 ? 890  ARG A O   1 
ATOM   4623 C  CB  . ARG A 1 627 ? -23.654 -75.976 -24.055 1.00 103.09 ? 890  ARG A CB  1 
ATOM   4624 C  CG  . ARG A 1 627 ? -24.921 -75.714 -24.858 1.00 99.18  ? 890  ARG A CG  1 
ATOM   4625 C  CD  . ARG A 1 627 ? -24.672 -74.795 -26.040 1.00 98.37  ? 890  ARG A CD  1 
ATOM   4626 N  NE  . ARG A 1 627 ? -23.409 -75.122 -26.679 1.00 99.18  ? 890  ARG A NE  1 
ATOM   4627 C  CZ  . ARG A 1 627 ? -23.187 -76.179 -27.458 1.00 102.41 ? 890  ARG A CZ  1 
ATOM   4628 N  NH1 . ARG A 1 627 ? -24.157 -77.038 -27.727 1.00 114.82 ? 890  ARG A NH1 1 
ATOM   4629 N  NH2 . ARG A 1 627 ? -21.986 -76.377 -27.975 1.00 101.61 ? 890  ARG A NH2 1 
ATOM   4630 N  N   . ARG A 1 628 ? -23.868 -78.985 -21.733 0.42 118.99 ? 891  ARG A N   1 
ATOM   4631 C  CA  . ARG A 1 628 ? -23.888 -80.473 -21.637 0.42 117.87 ? 891  ARG A CA  1 
ATOM   4632 C  C   . ARG A 1 628 ? -22.599 -81.061 -22.228 0.42 114.95 ? 891  ARG A C   1 
ATOM   4633 O  O   . ARG A 1 628 ? -21.522 -80.467 -22.174 0.42 112.15 ? 891  ARG A O   1 
ATOM   4634 C  CB  . ARG A 1 628 ? -25.119 -81.029 -22.361 0.42 119.29 ? 891  ARG A CB  1 
ATOM   4635 C  CG  . ARG A 1 628 ? -26.419 -80.322 -22.007 0.42 119.33 ? 891  ARG A CG  1 
ATOM   4636 C  CD  . ARG A 1 628 ? -26.722 -80.382 -20.522 0.42 120.67 ? 891  ARG A CD  1 
ATOM   4637 N  NE  . ARG A 1 628 ? -26.648 -81.741 -20.004 0.42 123.06 ? 891  ARG A NE  1 
ATOM   4638 C  CZ  . ARG A 1 628 ? -27.124 -82.127 -18.825 0.42 121.56 ? 891  ARG A CZ  1 
ATOM   4639 N  NH1 . ARG A 1 628 ? -27.720 -81.252 -18.033 0.42 122.27 ? 891  ARG A NH1 1 
ATOM   4640 N  NH2 . ARG A 1 628 ? -27.008 -83.386 -18.445 0.42 119.57 ? 891  ARG A NH2 1 
HETATM 4641 ZN ZN  . ZN  B 2 .   ? -6.517  -55.815 -23.857 1.00 21.53  2 1001 ZN  A ZN  1 
HETATM 4642 ZN ZN  . ZN  C 2 .   ? -25.747 -14.811 -13.553 0.50 36.43  2 1002 ZN  A ZN  1 
HETATM 4643 O  O1  A MES D 3 .   ? -28.315 -58.463 0.703   0.25 28.16  ? 1003 MES A O1  1 
HETATM 4644 O  O1  B MES D 3 .   ? -27.962 -57.968 0.151   0.25 510.98 ? 1003 MES A O1  1 
HETATM 4645 C  C2  A MES D 3 .   ? -27.585 -58.634 1.903   0.25 28.72  ? 1003 MES A C2  1 
HETATM 4646 C  C2  B MES D 3 .   ? -27.250 -58.339 1.321   0.25 515.99 ? 1003 MES A C2  1 
HETATM 4647 C  C3  A MES D 3 .   ? -26.201 -58.050 1.784   0.25 29.29  ? 1003 MES A C3  1 
HETATM 4648 C  C3  B MES D 3 .   ? -25.761 -58.331 1.082   0.25 516.41 ? 1003 MES A C3  1 
HETATM 4649 N  N4  A MES D 3 .   ? -25.477 -58.705 0.658   0.25 25.60  ? 1003 MES A N4  1 
HETATM 4650 N  N4  B MES D 3 .   ? -25.418 -59.274 -0.027  0.25 513.39 ? 1003 MES A N4  1 
HETATM 4651 C  C5  A MES D 3 .   ? -26.263 -58.559 -0.602  0.25 26.69  ? 1003 MES A C5  1 
HETATM 4652 C  C5  B MES D 3 .   ? -26.222 -58.916 -1.236  0.25 507.50 ? 1003 MES A C5  1 
HETATM 4653 C  C6  A MES D 3 .   ? -27.664 -59.089 -0.397  0.25 28.24  ? 1003 MES A C6  1 
HETATM 4654 C  C6  B MES D 3 .   ? -27.690 -58.891 -0.893  0.25 504.39 ? 1003 MES A C6  1 
HETATM 4655 C  C7  A MES D 3 .   ? -24.087 -58.167 0.505   0.25 25.86  ? 1003 MES A C7  1 
HETATM 4656 C  C7  B MES D 3 .   ? -23.947 -59.286 -0.324  0.25 517.32 ? 1003 MES A C7  1 
HETATM 4657 C  C8  A MES D 3 .   ? -23.186 -59.140 -0.224  0.25 25.77  ? 1003 MES A C8  1 
HETATM 4658 C  C8  B MES D 3 .   ? -23.175 -58.198 0.396   0.25 525.94 ? 1003 MES A C8  1 
HETATM 4659 S  S   A MES D 3 .   ? -21.463 -58.709 -0.014  0.25 25.86  ? 1003 MES A S   1 
HETATM 4660 S  S   B MES D 3 .   ? -21.421 -58.503 0.401   0.25 534.66 ? 1003 MES A S   1 
HETATM 4661 O  O1S A MES D 3 .   ? -21.060 -59.184 1.213   0.25 24.92  ? 1003 MES A O1S 1 
HETATM 4662 O  O1S B MES D 3 .   ? -21.266 -59.930 0.375   0.25 537.47 ? 1003 MES A O1S 1 
HETATM 4663 O  O2S A MES D 3 .   ? -20.835 -59.383 -1.186  0.25 25.04  ? 1003 MES A O2S 1 
HETATM 4664 O  O2S B MES D 3 .   ? -20.903 -57.870 -0.779  0.25 527.57 ? 1003 MES A O2S 1 
HETATM 4665 O  O3S A MES D 3 .   ? -21.414 -57.274 -0.200  0.25 25.73  ? 1003 MES A O3S 1 
HETATM 4666 O  O3S B MES D 3 .   ? -20.916 -57.914 1.609   0.25 534.10 ? 1003 MES A O3S 1 
HETATM 4667 S  S   . DMS E 4 .   ? -26.901 -62.610 -20.963 1.00 47.51  ? 1004 DMS A S   1 
HETATM 4668 O  O   . DMS E 4 .   ? -26.668 -63.297 -22.413 1.00 46.07  ? 1004 DMS A O   1 
HETATM 4669 C  C1  . DMS E 4 .   ? -28.104 -61.349 -21.217 1.00 41.41  ? 1004 DMS A C1  1 
HETATM 4670 C  C2  . DMS E 4 .   ? -25.498 -61.516 -20.827 1.00 52.32  ? 1004 DMS A C2  1 
HETATM 4671 S  S   . DMS F 4 .   ? -23.248 -48.572 -15.273 0.50 58.51  ? 1005 DMS A S   1 
HETATM 4672 O  O   . DMS F 4 .   ? -24.667 -48.279 -15.676 0.50 58.51  ? 1005 DMS A O   1 
HETATM 4673 C  C1  . DMS F 4 .   ? -22.351 -47.063 -15.543 0.50 57.53  ? 1005 DMS A C1  1 
HETATM 4674 C  C2  . DMS F 4 .   ? -22.539 -49.508 -16.599 0.50 52.03  ? 1005 DMS A C2  1 
HETATM 4675 C  C1  . PEG G 5 .   ? -30.175 -47.354 -25.864 0.50 48.56  ? 1006 PEG A C1  1 
HETATM 4676 O  O1  . PEG G 5 .   ? -30.340 -48.381 -26.830 0.50 46.36  ? 1006 PEG A O1  1 
HETATM 4677 C  C2  . PEG G 5 .   ? -30.946 -47.623 -24.603 0.50 48.17  ? 1006 PEG A C2  1 
HETATM 4678 O  O2  . PEG G 5 .   ? -30.402 -46.871 -23.522 0.50 50.69  ? 1006 PEG A O2  1 
HETATM 4679 C  C3  . PEG G 5 .   ? -31.384 -46.448 -22.580 0.50 48.52  ? 1006 PEG A C3  1 
HETATM 4680 C  C4  . PEG G 5 .   ? -30.931 -45.184 -21.903 0.50 50.50  ? 1006 PEG A C4  1 
HETATM 4681 O  O4  . PEG G 5 .   ? -30.553 -45.389 -20.551 0.50 49.38  ? 1006 PEG A O4  1 
HETATM 4682 P  P   . PO4 H 6 .   ? -4.553  -40.601 -23.830 0.50 33.46  ? 1007 PO4 A P   1 
HETATM 4683 O  O1  . PO4 H 6 .   ? -3.044  -40.985 -23.467 0.50 29.68  ? 1007 PO4 A O1  1 
HETATM 4684 O  O2  . PO4 H 6 .   ? -4.752  -39.148 -23.457 0.50 36.11  ? 1007 PO4 A O2  1 
HETATM 4685 O  O3  . PO4 H 6 .   ? -4.827  -40.828 -25.375 0.50 28.35  ? 1007 PO4 A O3  1 
HETATM 4686 O  O4  . PO4 H 6 .   ? -5.538  -41.462 -23.044 0.50 29.25  ? 1007 PO4 A O4  1 
HETATM 4687 P  P   . PO4 I 6 .   ? -18.021 -9.808  -29.307 1.00 108.07 ? 1008 PO4 A P   1 
HETATM 4688 O  O1  . PO4 I 6 .   ? -17.620 -10.306 -27.896 1.00 72.40  ? 1008 PO4 A O1  1 
HETATM 4689 O  O2  . PO4 I 6 .   ? -16.743 -9.527  -30.109 1.00 89.99  ? 1008 PO4 A O2  1 
HETATM 4690 O  O3  . PO4 I 6 .   ? -18.866 -10.905 -30.028 1.00 81.52  ? 1008 PO4 A O3  1 
HETATM 4691 O  O4  . PO4 I 6 .   ? -18.853 -8.494  -29.189 1.00 81.48  ? 1008 PO4 A O4  1 
HETATM 4692 C  C1  . PEG J 5 .   ? -16.402 -43.967 -41.130 1.00 67.92  ? 1009 PEG A C1  1 
HETATM 4693 O  O1  . PEG J 5 .   ? -17.711 -44.395 -40.821 1.00 60.24  ? 1009 PEG A O1  1 
HETATM 4694 C  C2  . PEG J 5 .   ? -15.818 -44.742 -42.263 1.00 70.66  ? 1009 PEG A C2  1 
HETATM 4695 O  O2  . PEG J 5 .   ? -16.497 -45.990 -42.392 1.00 69.82  ? 1009 PEG A O2  1 
HETATM 4696 C  C3  . PEG J 5 .   ? -16.473 -46.505 -43.723 1.00 72.19  ? 1009 PEG A C3  1 
HETATM 4697 C  C4  . PEG J 5 .   ? -15.317 -47.442 -43.906 1.00 71.81  ? 1009 PEG A C4  1 
HETATM 4698 O  O4  . PEG J 5 .   ? -15.732 -48.711 -44.392 1.00 65.11  ? 1009 PEG A O4  1 
HETATM 4699 N  N1  . O0J K 7 .   ? 0.024   -68.936 -21.267 0.48 39.68  ? 1010 O0J A N1  1 
HETATM 4700 C  C4  . O0J K 7 .   ? -3.974  -73.076 -19.665 0.48 47.96  ? 1010 O0J A C4  1 
HETATM 4701 C  C5  . O0J K 7 .   ? -3.635  -71.840 -20.203 0.48 45.77  ? 1010 O0J A C5  1 
HETATM 4702 C  C6  . O0J K 7 .   ? -4.649  -70.929 -20.467 0.48 47.56  ? 1010 O0J A C6  1 
HETATM 4703 C  C7  . O0J K 7 .   ? -5.970  -71.250 -20.218 0.48 47.10  ? 1010 O0J A C7  1 
HETATM 4704 C  C8  . O0J K 7 .   ? -2.229  -71.499 -20.469 0.48 44.64  ? 1010 O0J A C8  1 
HETATM 4705 C  C10 . O0J K 7 .   ? -0.595  -70.077 -20.969 0.48 45.00  ? 1010 O0J A C10 1 
HETATM 4706 N  N   . O0J K 7 .   ? -7.657  -72.822 -19.493 0.48 43.54  ? 1010 O0J A N   1 
HETATM 4707 C  C   . O0J K 7 .   ? -9.950  -72.126 -19.448 0.48 45.16  ? 1010 O0J A C   1 
HETATM 4708 O  O   . O0J K 7 .   ? -8.668  -72.309 -21.448 0.48 42.47  ? 1010 O0J A O   1 
HETATM 4709 C  C1  . O0J K 7 .   ? -8.714  -72.432 -20.231 0.48 45.04  ? 1010 O0J A C1  1 
HETATM 4710 C  C2  . O0J K 7 .   ? -6.302  -72.492 -19.698 0.48 47.83  ? 1010 O0J A C2  1 
HETATM 4711 C  C3  . O0J K 7 .   ? -5.293  -73.399 -19.411 0.48 46.08  ? 1010 O0J A C3  1 
HETATM 4712 C  C9  . O0J K 7 .   ? -1.170  -72.340 -20.340 0.48 44.03  ? 1010 O0J A C9  1 
HETATM 4713 N  N2  . O0J K 7 .   ? -1.896  -70.201 -20.838 0.48 45.42  ? 1010 O0J A N2  1 
HETATM 4714 S  S   . O0J K 7 .   ? 0.308   -71.540 -20.671 0.48 44.62  ? 1010 O0J A S   1 
HETATM 4715 CL CL  . CL  L 8 .   ? 4.031   -49.383 -29.841 1.00 38.49  ? 1011 CL  A CL  1 
HETATM 4716 O  O   . HOH M 9 .   ? -5.317  -33.646 -18.549 0.50 34.81  ? 1101 HOH A O   1 
HETATM 4717 O  O   . HOH M 9 .   ? -21.862 -10.362 -9.870  1.00 52.70  ? 1102 HOH A O   1 
HETATM 4718 O  O   . HOH M 9 .   ? -20.711 -48.839 -0.596  0.50 76.43  ? 1103 HOH A O   1 
HETATM 4719 O  O   . HOH M 9 .   ? -32.660 -52.449 -27.485 1.00 40.35  ? 1104 HOH A O   1 
HETATM 4720 O  O   . HOH M 9 .   ? -19.302 -38.659 -33.818 1.00 39.00  ? 1105 HOH A O   1 
HETATM 4721 O  O   . HOH M 9 .   ? -13.004 -22.553 -41.728 1.00 45.64  ? 1106 HOH A O   1 
HETATM 4722 O  O   . HOH M 9 .   ? -3.695  -38.231 -45.582 1.00 57.80  ? 1107 HOH A O   1 
HETATM 4723 O  O   . HOH M 9 .   ? 5.901   -45.358 -35.898 1.00 44.78  ? 1108 HOH A O   1 
HETATM 4724 O  O   . HOH M 9 .   ? -10.474 -70.795 -21.826 0.48 39.75  ? 1109 HOH A O   1 
HETATM 4725 O  O   . HOH M 9 .   ? -32.066 -71.373 -8.716  1.00 48.24  ? 1110 HOH A O   1 
HETATM 4726 O  O   . HOH M 9 .   ? -29.369 -51.256 -30.111 1.00 60.37  ? 1111 HOH A O   1 
HETATM 4727 O  O   . HOH M 9 .   ? -32.461 -60.999 -19.004 1.00 40.55  ? 1112 HOH A O   1 
HETATM 4728 O  O   . HOH M 9 .   ? -24.127 -70.228 -27.579 1.00 42.86  ? 1113 HOH A O   1 
HETATM 4729 O  O   . HOH M 9 .   ? -29.927 -50.779 -27.161 1.00 42.42  ? 1114 HOH A O   1 
HETATM 4730 O  O   . HOH M 9 .   ? -42.158 -64.045 -18.581 0.50 52.48  ? 1115 HOH A O   1 
HETATM 4731 O  O   . HOH M 9 .   ? -9.789  -64.855 -33.340 1.00 56.73  ? 1116 HOH A O   1 
HETATM 4732 O  O   . HOH M 9 .   ? -6.996  -20.839 -27.435 1.00 36.56  ? 1117 HOH A O   1 
HETATM 4733 O  O   . HOH M 9 .   ? -42.431 -63.618 -5.212  1.00 48.39  ? 1118 HOH A O   1 
HETATM 4734 O  O   . HOH M 9 .   ? -5.411  -58.984 -29.957 1.00 33.86  ? 1119 HOH A O   1 
HETATM 4735 O  O   . HOH M 9 .   ? -19.634 -27.762 -40.281 1.00 32.79  ? 1120 HOH A O   1 
HETATM 4736 O  O   . HOH M 9 .   ? -15.162 -55.022 -39.511 1.00 44.26  ? 1121 HOH A O   1 
HETATM 4737 O  O   . HOH M 9 .   ? -20.998 -47.796 -10.013 1.00 49.08  ? 1122 HOH A O   1 
HETATM 4738 O  O   . HOH M 9 .   ? -32.403 -49.604 -18.699 1.00 47.05  ? 1123 HOH A O   1 
HETATM 4739 O  O   . HOH M 9 .   ? 11.317  -34.764 -33.307 1.00 43.33  ? 1124 HOH A O   1 
HETATM 4740 O  O   . HOH M 9 .   ? -19.976 -66.924 -37.714 1.00 48.28  ? 1125 HOH A O   1 
HETATM 4741 O  O   . HOH M 9 .   ? -38.289 -68.175 -8.347  1.00 35.15  ? 1126 HOH A O   1 
HETATM 4742 O  O   . HOH M 9 .   ? -4.213  -54.227 -28.158 1.00 26.20  ? 1127 HOH A O   1 
HETATM 4743 O  O   . HOH M 9 .   ? -8.923  -37.460 -19.841 1.00 52.13  ? 1128 HOH A O   1 
HETATM 4744 O  O   . HOH M 9 .   ? -27.075 -66.199 -40.054 1.00 44.91  ? 1129 HOH A O   1 
HETATM 4745 O  O   . HOH M 9 .   ? -34.985 -50.883 -12.919 1.00 40.32  ? 1130 HOH A O   1 
HETATM 4746 O  O   . HOH M 9 .   ? -29.282 -56.577 -36.403 1.00 44.36  ? 1131 HOH A O   1 
HETATM 4747 O  O   . HOH M 9 .   ? 6.306   -31.967 -19.632 0.50 26.12  ? 1132 HOH A O   1 
HETATM 4748 O  O   . HOH M 9 .   ? -22.567 -54.155 -46.640 1.00 47.39  ? 1133 HOH A O   1 
HETATM 4749 O  O   . HOH M 9 .   ? -10.297 -75.787 -8.851  0.48 36.17  ? 1134 HOH A O   1 
HETATM 4750 O  O   . HOH M 9 .   ? -42.445 -62.387 -14.883 1.00 34.30  ? 1135 HOH A O   1 
HETATM 4751 O  O   . HOH M 9 .   ? -17.771 -41.823 -37.264 0.50 49.18  ? 1136 HOH A O   1 
HETATM 4752 O  O   . HOH M 9 .   ? -28.527 -70.260 -13.996 1.00 46.71  ? 1137 HOH A O   1 
HETATM 4753 O  O   . HOH M 9 .   ? -24.577 -14.487 -5.079  1.00 55.08  ? 1138 HOH A O   1 
HETATM 4754 O  O   . HOH M 9 .   ? -23.167 -65.848 -38.885 1.00 49.11  ? 1139 HOH A O   1 
HETATM 4755 O  O   . HOH M 9 .   ? -34.734 -21.228 -24.007 1.00 47.11  ? 1140 HOH A O   1 
HETATM 4756 O  O   . HOH M 9 .   ? -1.871  -42.152 -21.503 1.00 58.20  ? 1141 HOH A O   1 
HETATM 4757 O  O   . HOH M 9 .   ? -28.009 -47.252 0.206   0.50 42.85  ? 1142 HOH A O   1 
HETATM 4758 O  O   . HOH M 9 .   ? 3.524   -43.874 -43.312 1.00 51.34  ? 1143 HOH A O   1 
HETATM 4759 O  O   . HOH M 9 .   ? -8.929  -64.680 -30.964 1.00 42.77  ? 1144 HOH A O   1 
HETATM 4760 O  O   . HOH M 9 .   ? -40.072 -24.473 -26.541 1.00 47.07  ? 1145 HOH A O   1 
HETATM 4761 O  O   . HOH M 9 .   ? -16.738 -32.727 -18.419 1.00 46.67  ? 1146 HOH A O   1 
HETATM 4762 O  O   . HOH M 9 .   ? -12.805 -43.393 -39.086 1.00 38.04  ? 1147 HOH A O   1 
HETATM 4763 O  O   . HOH M 9 .   ? -5.900  -69.720 -7.393  0.48 22.53  ? 1148 HOH A O   1 
HETATM 4764 O  O   . HOH M 9 .   ? 1.406   -32.875 -39.004 1.00 26.45  ? 1149 HOH A O   1 
HETATM 4765 O  O   . HOH M 9 .   ? 0.028   -31.599 -23.347 1.00 30.54  ? 1150 HOH A O   1 
HETATM 4766 O  O   . HOH M 9 .   ? -2.606  -49.550 -39.782 1.00 49.30  ? 1151 HOH A O   1 
HETATM 4767 O  O   . HOH M 9 .   ? -10.875 -62.860 -18.790 1.00 18.11  ? 1152 HOH A O   1 
HETATM 4768 O  O   . HOH M 9 .   ? -28.123 -18.714 -35.270 1.00 44.43  ? 1153 HOH A O   1 
HETATM 4769 O  O   . HOH M 9 .   ? -8.973  -59.523 -13.281 1.00 24.77  ? 1154 HOH A O   1 
HETATM 4770 O  O   . HOH M 9 .   ? -9.403  -21.909 -27.573 1.00 36.20  ? 1155 HOH A O   1 
HETATM 4771 O  O   . HOH M 9 .   ? 7.844   -43.386 -36.598 1.00 41.24  ? 1156 HOH A O   1 
HETATM 4772 O  O   . HOH M 9 .   ? -7.691  -43.230 -43.064 1.00 42.89  ? 1157 HOH A O   1 
HETATM 4773 O  O   . HOH M 9 .   ? 8.778   -40.575 -32.166 1.00 47.34  ? 1158 HOH A O   1 
HETATM 4774 O  O   . HOH M 9 .   ? 0.063   -33.384 -28.070 1.00 27.57  ? 1159 HOH A O   1 
HETATM 4775 O  O   . HOH M 9 .   ? -11.752 -47.893 -43.288 1.00 51.29  ? 1160 HOH A O   1 
HETATM 4776 O  O   . HOH M 9 .   ? -4.941  -16.089 -28.563 1.00 42.50  ? 1161 HOH A O   1 
HETATM 4777 O  O   . HOH M 9 .   ? -41.711 -59.372 -6.156  0.50 28.38  ? 1162 HOH A O   1 
HETATM 4778 O  O   . HOH M 9 .   ? -15.426 -37.304 -40.460 0.50 28.37  ? 1163 HOH A O   1 
HETATM 4779 O  O   . HOH M 9 .   ? 10.418  -39.119 -29.852 1.00 51.87  ? 1164 HOH A O   1 
HETATM 4780 O  O   . HOH M 9 .   ? -19.092 -20.935 -40.477 0.50 44.20  ? 1165 HOH A O   1 
HETATM 4781 O  O   . HOH M 9 .   ? -14.621 -64.547 -0.521  1.00 26.62  ? 1166 HOH A O   1 
HETATM 4782 O  O   . HOH M 9 .   ? -13.628 -74.764 -14.323 1.00 46.03  ? 1167 HOH A O   1 
HETATM 4783 O  O   . HOH M 9 .   ? -12.953 -54.135 -40.622 1.00 52.07  ? 1168 HOH A O   1 
HETATM 4784 O  O   . HOH M 9 .   ? 4.865   -16.980 -21.940 1.00 58.97  ? 1169 HOH A O   1 
HETATM 4785 O  O   . HOH M 9 .   ? 5.811   -33.268 -37.984 1.00 39.77  ? 1170 HOH A O   1 
HETATM 4786 O  O   . HOH M 9 .   ? -20.720 -29.549 -25.177 1.00 37.17  ? 1171 HOH A O   1 
HETATM 4787 O  O   . HOH M 9 .   ? -12.316 -37.583 -39.698 0.50 34.84  ? 1172 HOH A O   1 
HETATM 4788 O  O   . HOH M 9 .   ? -17.842 -66.572 -36.096 1.00 40.12  ? 1173 HOH A O   1 
HETATM 4789 O  O   . HOH M 9 .   ? -5.258  -60.632 -0.883  1.00 39.62  ? 1174 HOH A O   1 
HETATM 4790 O  O   . HOH M 9 .   ? -16.272 -12.545 -29.828 0.50 61.47  ? 1175 HOH A O   1 
HETATM 4791 O  O   . HOH M 9 .   ? -16.802 -68.389 -29.135 0.48 26.20  ? 1176 HOH A O   1 
HETATM 4792 O  O   . HOH M 9 .   ? 5.532   -30.580 -21.957 1.00 36.39  ? 1177 HOH A O   1 
HETATM 4793 O  O   . HOH M 9 .   ? -21.290 -50.141 -35.099 0.50 33.77  ? 1178 HOH A O   1 
HETATM 4794 O  O   . HOH M 9 .   ? -17.830 -62.649 -3.044  1.00 23.02  ? 1179 HOH A O   1 
HETATM 4795 O  O   . HOH M 9 .   ? -6.527  -43.374 -21.465 1.00 53.95  ? 1180 HOH A O   1 
HETATM 4796 O  O   . HOH M 9 .   ? -23.158 -33.579 -36.493 0.50 26.41  ? 1181 HOH A O   1 
HETATM 4797 O  O   . HOH M 9 .   ? -3.751  -71.406 -9.225  1.00 46.16  ? 1182 HOH A O   1 
HETATM 4798 O  O   . HOH M 9 .   ? -3.765  -15.825 -20.962 1.00 49.31  ? 1183 HOH A O   1 
HETATM 4799 O  O   . HOH M 9 .   ? -35.915 -58.850 -3.411  0.50 27.02  ? 1184 HOH A O   1 
HETATM 4800 O  O   . HOH M 9 .   ? -33.596 -57.842 -19.552 1.00 35.89  ? 1185 HOH A O   1 
HETATM 4801 O  O   . HOH M 9 .   ? -26.639 -25.960 -33.506 1.00 29.70  ? 1186 HOH A O   1 
HETATM 4802 O  O   . HOH M 9 .   ? -26.490 -31.224 -23.730 1.00 49.28  ? 1187 HOH A O   1 
HETATM 4803 O  O   . HOH M 9 .   ? -4.405  -54.603 -11.861 1.00 47.22  ? 1188 HOH A O   1 
HETATM 4804 O  O   . HOH M 9 .   ? -11.004 -48.882 -39.308 1.00 26.32  ? 1189 HOH A O   1 
HETATM 4805 O  O   . HOH M 9 .   ? -7.303  -47.827 -18.241 1.00 32.95  ? 1190 HOH A O   1 
HETATM 4806 O  O   . HOH M 9 .   ? -38.337 -61.448 -14.226 1.00 32.49  ? 1191 HOH A O   1 
HETATM 4807 O  O   . HOH M 9 .   ? -13.776 -45.780 -3.682  0.50 37.57  ? 1192 HOH A O   1 
HETATM 4808 O  O   . HOH M 9 .   ? -22.750 -37.691 -37.529 1.00 45.67  ? 1193 HOH A O   1 
HETATM 4809 O  O   . HOH M 9 .   ? -36.803 -50.711 -5.359  1.00 34.93  ? 1194 HOH A O   1 
HETATM 4810 O  O   . HOH M 9 .   ? -14.830 -17.621 -36.360 1.00 46.34  ? 1195 HOH A O   1 
HETATM 4811 O  O   . HOH M 9 .   ? 2.625   -40.006 -27.021 1.00 32.54  ? 1196 HOH A O   1 
HETATM 4812 O  O   . HOH M 9 .   ? 10.495  -30.449 -34.455 1.00 44.10  ? 1197 HOH A O   1 
HETATM 4813 O  O   . HOH M 9 .   ? -32.753 -64.049 -15.081 1.00 28.97  ? 1198 HOH A O   1 
HETATM 4814 O  O   . HOH M 9 .   ? -22.385 -51.564 -9.116  1.00 25.37  ? 1199 HOH A O   1 
HETATM 4815 O  O   . HOH M 9 .   ? -17.750 -31.694 -42.009 0.50 30.32  ? 1200 HOH A O   1 
HETATM 4816 O  O   . HOH M 9 .   ? -3.762  -62.035 -15.504 1.00 28.06  ? 1201 HOH A O   1 
HETATM 4817 O  O   . HOH M 9 .   ? -34.186 -22.226 -30.072 0.50 29.68  ? 1202 HOH A O   1 
HETATM 4818 O  O   . HOH M 9 .   ? -35.393 -67.177 -0.660  1.00 34.91  ? 1203 HOH A O   1 
HETATM 4819 O  O   . HOH M 9 .   ? 7.707   -22.494 -25.001 1.00 41.48  ? 1204 HOH A O   1 
HETATM 4820 O  O   . HOH M 9 .   ? -12.369 -58.708 -0.000  0.50 21.25  ? 1205 HOH A O   1 
HETATM 4821 O  O   . HOH M 9 .   ? -15.685 -27.580 -46.272 1.00 58.00  ? 1206 HOH A O   1 
HETATM 4822 O  O   . HOH M 9 .   ? -16.414 -67.208 -20.834 1.00 40.23  ? 1207 HOH A O   1 
HETATM 4823 O  O   . HOH M 9 .   ? -33.638 -47.900 -3.874  0.50 35.58  ? 1208 HOH A O   1 
HETATM 4824 O  O   . HOH M 9 .   ? -28.403 -50.510 0.228   1.00 30.20  ? 1209 HOH A O   1 
HETATM 4825 O  O   . HOH M 9 .   ? 10.583  -27.376 -29.537 1.00 48.73  ? 1210 HOH A O   1 
HETATM 4826 O  O   . HOH M 9 .   ? -14.006 -50.331 -32.399 0.34 21.31  ? 1211 HOH A O   1 
HETATM 4827 O  O   . HOH M 9 .   ? -2.615  -58.530 -27.553 1.00 26.96  ? 1212 HOH A O   1 
HETATM 4828 O  O   . HOH M 9 .   ? -16.834 -28.776 -40.852 0.50 37.36  ? 1213 HOH A O   1 
HETATM 4829 O  O   . HOH M 9 .   ? -7.843  -58.101 -1.266  1.00 53.34  ? 1214 HOH A O   1 
HETATM 4830 O  O   . HOH M 9 .   ? -5.758  -59.746 -12.237 1.00 41.07  ? 1215 HOH A O   1 
HETATM 4831 O  O   . HOH M 9 .   ? -0.712  -11.573 -30.550 1.00 49.96  ? 1216 HOH A O   1 
HETATM 4832 O  O   . HOH M 9 .   ? -26.415 -51.722 -2.542  0.50 36.94  ? 1217 HOH A O   1 
HETATM 4833 O  O   . HOH M 9 .   ? 1.145   -41.897 -24.551 1.00 37.16  ? 1218 HOH A O   1 
HETATM 4834 O  O   . HOH M 9 .   ? -31.884 -57.736 -21.644 1.00 32.37  ? 1219 HOH A O   1 
HETATM 4835 O  O   . HOH M 9 .   ? -23.110 -27.911 -24.941 1.00 37.68  ? 1220 HOH A O   1 
HETATM 4836 O  O   . HOH M 9 .   ? -22.159 -74.784 -11.425 1.00 30.48  ? 1221 HOH A O   1 
HETATM 4837 O  O   . HOH M 9 .   ? -3.056  -55.644 -18.228 1.00 25.79  ? 1222 HOH A O   1 
HETATM 4838 O  O   . HOH M 9 .   ? -21.692 -66.681 -4.497  1.00 35.66  ? 1223 HOH A O   1 
HETATM 4839 O  O   . HOH M 9 .   ? -29.359 -63.816 -34.358 1.00 49.66  ? 1224 HOH A O   1 
HETATM 4840 O  O   . HOH M 9 .   ? -38.819 -57.629 -20.385 1.00 43.70  ? 1225 HOH A O   1 
HETATM 4841 O  O   . HOH M 9 .   ? -22.578 -66.349 -23.693 1.00 34.23  ? 1226 HOH A O   1 
HETATM 4842 O  O   . HOH M 9 .   ? -5.293  -49.186 -28.776 1.00 25.85  ? 1227 HOH A O   1 
HETATM 4843 O  O   . HOH M 9 .   ? 10.096  -26.436 -32.713 0.50 31.37  ? 1228 HOH A O   1 
HETATM 4844 O  O   . HOH M 9 .   ? -9.027  -27.021 -44.857 1.00 39.73  ? 1229 HOH A O   1 
HETATM 4845 O  O   . HOH M 9 .   ? -3.651  -55.911 -35.898 1.00 53.39  ? 1230 HOH A O   1 
HETATM 4846 O  O   . HOH M 9 .   ? 4.076   -27.090 -29.798 1.00 37.07  ? 1231 HOH A O   1 
HETATM 4847 O  O   . HOH M 9 .   ? -29.518 -34.170 -28.770 1.00 46.73  ? 1232 HOH A O   1 
HETATM 4848 O  O   . HOH M 9 .   ? -40.184 -61.789 -11.450 1.00 27.92  ? 1233 HOH A O   1 
HETATM 4849 O  O   . HOH M 9 .   ? -4.635  -62.925 -4.636  1.00 44.66  ? 1234 HOH A O   1 
HETATM 4850 O  O   . HOH M 9 .   ? -4.332  -65.967 -15.351 1.00 35.49  ? 1235 HOH A O   1 
HETATM 4851 O  O   . HOH M 9 .   ? -24.251 -70.350 -34.140 1.00 52.05  ? 1236 HOH A O   1 
HETATM 4852 O  O   . HOH M 9 .   ? -8.842  -71.613 -14.784 1.00 37.81  ? 1237 HOH A O   1 
HETATM 4853 O  O   . HOH M 9 .   ? -22.930 -27.995 -19.275 1.00 53.57  ? 1238 HOH A O   1 
HETATM 4854 O  O   . HOH M 9 .   ? 10.943  -41.059 -37.771 1.00 48.96  ? 1239 HOH A O   1 
HETATM 4855 O  O   . HOH M 9 .   ? -30.321 -57.464 -34.343 1.00 34.55  ? 1240 HOH A O   1 
HETATM 4856 O  O   . HOH M 9 .   ? -34.450 -28.842 -30.354 1.00 39.96  ? 1241 HOH A O   1 
HETATM 4857 O  O   . HOH M 9 .   ? -27.871 -23.483 -26.736 1.00 33.37  ? 1242 HOH A O   1 
HETATM 4858 O  O   . HOH M 9 .   ? -8.283  -65.423 -6.980  1.00 29.59  ? 1243 HOH A O   1 
HETATM 4859 O  O   . HOH M 9 .   ? -7.045  -61.268 -30.619 1.00 51.27  ? 1244 HOH A O   1 
HETATM 4860 O  O   . HOH M 9 .   ? -17.537 -58.246 -43.696 0.50 24.64  ? 1245 HOH A O   1 
HETATM 4861 O  O   . HOH M 9 .   ? -27.246 -57.688 -40.050 1.00 43.53  ? 1246 HOH A O   1 
HETATM 4862 O  O   . HOH M 9 .   ? -14.705 -69.038 -19.725 1.00 41.33  ? 1247 HOH A O   1 
HETATM 4863 O  O   . HOH M 9 .   ? -36.165 -58.687 -20.785 1.00 42.71  ? 1248 HOH A O   1 
HETATM 4864 O  O   . HOH M 9 .   ? -18.665 -65.735 -7.246  1.00 19.20  ? 1249 HOH A O   1 
HETATM 4865 O  O   . HOH M 9 .   ? -6.615  -37.471 -20.765 1.00 46.77  ? 1250 HOH A O   1 
HETATM 4866 O  O   . HOH M 9 .   ? -15.339 -66.588 -33.788 1.00 44.73  ? 1251 HOH A O   1 
HETATM 4867 O  O   . HOH M 9 .   ? -15.103 -35.456 -29.289 0.66 26.39  ? 1252 HOH A O   1 
HETATM 4868 O  O   . HOH M 9 .   ? -29.144 -18.302 -20.972 1.00 46.66  ? 1253 HOH A O   1 
HETATM 4869 O  O   . HOH M 9 .   ? 5.552   -38.973 -24.434 1.00 42.74  ? 1254 HOH A O   1 
HETATM 4870 O  O   . HOH M 9 .   ? 2.768   -64.972 -20.982 1.00 25.39  ? 1255 HOH A O   1 
HETATM 4871 O  O   . HOH M 9 .   ? -5.811  -50.856 -18.683 1.00 32.17  ? 1256 HOH A O   1 
HETATM 4872 O  O   . HOH M 9 .   ? -7.155  -50.281 -6.807  1.00 51.58  ? 1257 HOH A O   1 
HETATM 4873 O  O   . HOH M 9 .   ? -11.249 -47.045 3.875   1.00 40.88  ? 1258 HOH A O   1 
HETATM 4874 O  O   . HOH M 9 .   ? -31.711 -60.540 -15.887 1.00 29.48  ? 1259 HOH A O   1 
HETATM 4875 O  O   . HOH M 9 .   ? 3.401   -31.862 -37.481 1.00 30.27  ? 1260 HOH A O   1 
HETATM 4876 O  O   . HOH M 9 .   ? 4.055   -29.501 -44.724 1.00 40.77  ? 1261 HOH A O   1 
HETATM 4877 O  O   . HOH M 9 .   ? -20.896 -32.173 -29.547 1.00 30.26  ? 1262 HOH A O   1 
HETATM 4878 O  O   . HOH M 9 .   ? -24.930 -53.974 -1.919  1.00 27.48  ? 1263 HOH A O   1 
HETATM 4879 O  O   . HOH M 9 .   ? -34.732 -63.371 0.669   1.00 25.28  ? 1264 HOH A O   1 
HETATM 4880 O  O   . HOH M 9 .   ? -13.554 -54.192 -1.572  1.00 23.16  ? 1265 HOH A O   1 
HETATM 4881 O  O   . HOH M 9 .   ? -26.416 -71.840 -3.475  1.00 37.89  ? 1266 HOH A O   1 
HETATM 4882 O  O   . HOH M 9 .   ? -39.139 -62.293 -4.124  0.50 46.82  ? 1267 HOH A O   1 
HETATM 4883 O  O   . HOH M 9 .   ? -18.948 -70.263 -8.283  1.00 26.62  ? 1268 HOH A O   1 
HETATM 4884 O  O   . HOH M 9 .   ? -16.989 -52.452 -15.567 1.00 21.17  ? 1269 HOH A O   1 
HETATM 4885 O  O   . HOH M 9 .   ? -38.770 -55.586 -18.995 1.00 40.48  ? 1270 HOH A O   1 
HETATM 4886 O  O   . HOH M 9 .   ? -29.773 -60.157 -19.746 1.00 35.24  ? 1271 HOH A O   1 
HETATM 4887 O  O   . HOH M 9 .   ? -20.525 -67.818 -25.300 1.00 27.98  ? 1272 HOH A O   1 
HETATM 4888 O  O   . HOH M 9 .   ? -22.576 -20.282 -16.156 1.00 55.93  ? 1273 HOH A O   1 
HETATM 4889 O  O   . HOH M 9 .   ? -30.126 -61.341 -23.110 1.00 31.59  ? 1274 HOH A O   1 
HETATM 4890 O  O   . HOH M 9 .   ? -23.367 -50.428 -42.185 1.00 39.95  ? 1275 HOH A O   1 
HETATM 4891 O  O   . HOH M 9 .   ? -39.753 -64.512 -2.236  1.00 46.69  ? 1276 HOH A O   1 
HETATM 4892 O  O   . HOH M 9 .   ? -14.029 -52.702 -5.904  1.00 24.36  ? 1277 HOH A O   1 
HETATM 4893 O  O   . HOH M 9 .   ? -19.104 -68.883 -1.859  1.00 39.33  ? 1278 HOH A O   1 
HETATM 4894 O  O   . HOH M 9 .   ? -28.808 -46.263 2.655   1.00 39.16  ? 1279 HOH A O   1 
HETATM 4895 O  O   . HOH M 9 .   ? -14.133 -56.976 -1.489  1.00 21.32  ? 1280 HOH A O   1 
HETATM 4896 O  O   . HOH M 9 .   ? -4.221  -23.632 -25.555 1.00 34.11  ? 1281 HOH A O   1 
HETATM 4897 O  O   . HOH M 9 .   ? -2.204  -40.461 -45.970 1.00 42.93  ? 1282 HOH A O   1 
HETATM 4898 O  O   . HOH M 9 .   ? -3.345  -20.657 -23.834 1.00 41.25  ? 1283 HOH A O   1 
HETATM 4899 O  O   . HOH M 9 .   ? -31.990 -19.342 -30.844 1.00 50.24  ? 1284 HOH A O   1 
HETATM 4900 O  O   . HOH M 9 .   ? -8.729  -28.112 -46.993 1.00 51.33  ? 1285 HOH A O   1 
HETATM 4901 O  O   . HOH M 9 .   ? -28.336 -49.632 -31.827 1.00 43.88  ? 1286 HOH A O   1 
HETATM 4902 O  O   . HOH M 9 .   ? -27.370 -16.070 -20.132 1.00 48.87  ? 1287 HOH A O   1 
HETATM 4903 O  O   . HOH M 9 .   ? -5.976  -49.608 -21.337 1.00 26.33  ? 1288 HOH A O   1 
HETATM 4904 O  O   . HOH M 9 .   ? -0.035  -64.531 -20.342 0.48 28.48  ? 1289 HOH A O   1 
HETATM 4905 O  O   . HOH M 9 .   ? -4.880  -56.848 -31.600 1.00 28.06  ? 1290 HOH A O   1 
HETATM 4906 O  O   . HOH M 9 .   ? -33.982 -70.671 -18.312 1.00 40.05  ? 1291 HOH A O   1 
HETATM 4907 O  O   . HOH M 9 .   ? -24.446 -69.482 -38.160 1.00 47.11  ? 1292 HOH A O   1 
HETATM 4908 O  O   . HOH M 9 .   ? 8.796   -24.602 -36.150 1.00 54.62  ? 1293 HOH A O   1 
HETATM 4909 O  O   . HOH M 9 .   ? -27.207 -27.025 -36.011 1.00 34.50  ? 1294 HOH A O   1 
HETATM 4910 O  O   . HOH M 9 .   ? -24.618 -30.964 -40.220 1.00 50.74  ? 1295 HOH A O   1 
HETATM 4911 O  O   . HOH M 9 .   ? -27.994 -17.234 -32.633 1.00 37.19  ? 1296 HOH A O   1 
HETATM 4912 O  O   . HOH M 9 .   ? -0.367  -36.126 -28.356 1.00 33.28  ? 1297 HOH A O   1 
HETATM 4913 O  O   . HOH M 9 .   ? -35.313 -58.597 -27.818 1.00 50.78  ? 1298 HOH A O   1 
HETATM 4914 O  O   . HOH M 9 .   ? -35.776 -54.638 -3.232  1.00 29.98  ? 1299 HOH A O   1 
HETATM 4915 O  O   . HOH M 9 .   ? 9.988   -38.149 -39.426 0.50 35.67  ? 1300 HOH A O   1 
HETATM 4916 O  O   . HOH M 9 .   ? -20.871 -76.042 -5.674  1.00 54.77  ? 1301 HOH A O   1 
HETATM 4917 O  O   . HOH M 9 .   ? -12.346 -44.722 -16.643 1.00 50.74  ? 1302 HOH A O   1 
HETATM 4918 O  O   . HOH M 9 .   ? -24.109 -58.744 -46.621 1.00 43.64  ? 1303 HOH A O   1 
HETATM 4919 O  O   . HOH M 9 .   ? -15.490 -55.599 -43.588 1.00 50.32  ? 1304 HOH A O   1 
HETATM 4920 O  O   . HOH M 9 .   ? -18.648 -50.102 -35.353 1.00 42.37  ? 1305 HOH A O   1 
HETATM 4921 O  O   . HOH M 9 .   ? -14.726 -54.756 -4.146  1.00 22.50  ? 1306 HOH A O   1 
HETATM 4922 O  O   . HOH M 9 .   ? -2.574  -60.790 -31.634 0.50 43.88  ? 1307 HOH A O   1 
HETATM 4923 O  O   . HOH M 9 .   ? -21.331 -41.844 -35.822 0.50 29.42  ? 1308 HOH A O   1 
HETATM 4924 O  O   . HOH M 9 .   ? -3.704  -56.954 -7.137  1.00 30.57  ? 1309 HOH A O   1 
HETATM 4925 O  O   . HOH M 9 .   ? -35.257 -59.789 -0.747  1.00 46.37  ? 1310 HOH A O   1 
HETATM 4926 O  O   . HOH M 9 .   ? -15.146 -49.020 -18.780 1.00 32.32  ? 1311 HOH A O   1 
HETATM 4927 O  O   . HOH M 9 .   ? -29.953 -62.010 -33.161 1.00 48.55  ? 1312 HOH A O   1 
HETATM 4928 O  O   . HOH M 9 .   ? -39.282 -56.118 -6.131  0.66 31.97  ? 1313 HOH A O   1 
HETATM 4929 O  O   . HOH M 9 .   ? -5.863  -69.085 -27.532 1.00 31.47  ? 1314 HOH A O   1 
HETATM 4930 O  O   . HOH M 9 .   ? -20.159 -47.115 -25.684 0.50 21.20  ? 1315 HOH A O   1 
HETATM 4931 O  O   . HOH M 9 .   ? -41.137 -58.708 -9.809  0.50 26.19  ? 1316 HOH A O   1 
HETATM 4932 O  O   . HOH M 9 .   ? -37.255 -52.836 -12.651 0.50 25.69  ? 1317 HOH A O   1 
HETATM 4933 O  O   . HOH M 9 .   ? -7.834  -30.503 -46.213 1.00 40.27  ? 1318 HOH A O   1 
HETATM 4934 O  O   . HOH M 9 .   ? -10.797 -70.537 -25.749 0.48 25.37  ? 1319 HOH A O   1 
HETATM 4935 O  O   . HOH M 9 .   ? -14.276 -21.206 -17.173 0.50 34.79  ? 1320 HOH A O   1 
HETATM 4936 O  O   . HOH M 9 .   ? 7.133   -50.695 -31.101 1.00 51.51  ? 1321 HOH A O   1 
HETATM 4937 O  O   . HOH M 9 .   ? -42.622 -65.773 -19.289 0.50 46.54  ? 1322 HOH A O   1 
HETATM 4938 O  O   . HOH M 9 .   ? 15.497  -34.756 -22.096 1.00 60.15  ? 1323 HOH A O   1 
HETATM 4939 O  O   . HOH M 9 .   ? -34.915 -60.167 -29.629 1.00 56.37  ? 1324 HOH A O   1 
HETATM 4940 O  O   . HOH M 9 .   ? -7.452  -51.783 -10.451 1.00 48.08  ? 1325 HOH A O   1 
HETATM 4941 O  O   . HOH M 9 .   ? -0.193  -48.618 -36.459 1.00 32.03  ? 1326 HOH A O   1 
HETATM 4942 O  O   . HOH M 9 .   ? -33.778 -47.644 -15.436 1.00 55.40  ? 1327 HOH A O   1 
HETATM 4943 O  O   . HOH M 9 .   ? -5.064  -35.329 -20.670 0.50 28.88  ? 1328 HOH A O   1 
HETATM 4944 O  O   . HOH M 9 .   ? -4.013  -57.713 -13.573 1.00 37.93  ? 1329 HOH A O   1 
HETATM 4945 O  O   . HOH M 9 .   ? -22.821 -21.159 -38.022 1.00 46.81  ? 1330 HOH A O   1 
HETATM 4946 O  O   . HOH M 9 .   ? -14.769 -70.750 -3.280  1.00 50.52  ? 1331 HOH A O   1 
HETATM 4947 O  O   . HOH M 9 .   ? -23.017 -63.683 -23.410 1.00 39.14  ? 1332 HOH A O   1 
HETATM 4948 O  O   . HOH M 9 .   ? -16.262 -49.691 -16.231 1.00 25.90  ? 1333 HOH A O   1 
HETATM 4949 O  O   . HOH M 9 .   ? -3.028  -58.665 -24.711 1.00 21.83  ? 1334 HOH A O   1 
HETATM 4950 O  O   . HOH M 9 .   ? -27.523 -40.765 -5.297  1.00 55.54  ? 1335 HOH A O   1 
HETATM 4951 O  O   . HOH M 9 .   ? -19.126 -65.151 -3.020  1.00 32.89  ? 1336 HOH A O   1 
HETATM 4952 O  O   . HOH M 9 .   ? 3.252   -69.961 -20.819 0.46 28.02  ? 1337 HOH A O   1 
HETATM 4953 O  O   . HOH M 9 .   ? -1.056  -32.896 -25.708 1.00 27.89  ? 1338 HOH A O   1 
HETATM 4954 O  O   . HOH M 9 .   ? -4.748  -53.210 -38.998 1.00 52.37  ? 1339 HOH A O   1 
HETATM 4955 O  O   . HOH M 9 .   ? 7.597   -48.985 -29.488 0.48 52.51  ? 1340 HOH A O   1 
HETATM 4956 O  O   . HOH M 9 .   ? -20.323 -31.892 -26.925 1.00 33.49  ? 1341 HOH A O   1 
HETATM 4957 O  O   . HOH M 9 .   ? -14.713 -57.810 -41.937 1.00 31.34  ? 1342 HOH A O   1 
HETATM 4958 O  O   . HOH M 9 .   ? -28.646 -63.511 -25.260 1.00 34.99  ? 1343 HOH A O   1 
HETATM 4959 O  O   . HOH M 9 .   ? 13.202  -30.782 -19.565 0.50 34.93  ? 1344 HOH A O   1 
HETATM 4960 O  O   . HOH M 9 .   ? -12.696 -38.396 -22.522 1.00 48.10  ? 1345 HOH A O   1 
HETATM 4961 O  O   . HOH M 9 .   ? -12.557 -67.825 -29.369 0.48 21.31  ? 1346 HOH A O   1 
HETATM 4962 O  O   . HOH M 9 .   ? -20.216 -71.135 -5.815  1.00 35.84  ? 1347 HOH A O   1 
HETATM 4963 O  O   . HOH M 9 .   ? -34.915 -68.205 -5.416  1.00 43.32  ? 1348 HOH A O   1 
HETATM 4964 O  O   . HOH M 9 .   ? -37.671 -68.856 -12.359 1.00 44.63  ? 1349 HOH A O   1 
HETATM 4965 O  O   . HOH M 9 .   ? -23.356 -45.806 -8.931  1.00 47.09  ? 1350 HOH A O   1 
HETATM 4966 O  O   . HOH M 9 .   ? -3.067  -73.293 -6.616  1.00 63.93  ? 1351 HOH A O   1 
HETATM 4967 O  O   . HOH M 9 .   ? -23.283 -37.525 -33.352 0.50 27.63  ? 1352 HOH A O   1 
HETATM 4968 O  O   . HOH M 9 .   ? -13.753 -51.702 -43.347 1.00 51.98  ? 1353 HOH A O   1 
HETATM 4969 O  O   . HOH M 9 .   ? -11.637 -72.381 -15.758 1.00 27.14  ? 1354 HOH A O   1 
HETATM 4970 O  O   . HOH M 9 .   ? -28.876 -70.487 -22.372 1.00 59.69  ? 1355 HOH A O   1 
HETATM 4971 O  O   . HOH M 9 .   ? -37.907 -28.313 -27.716 0.50 41.24  ? 1356 HOH A O   1 
HETATM 4972 O  O   . HOH M 9 .   ? -26.615 -68.304 -27.833 1.00 30.49  ? 1357 HOH A O   1 
HETATM 4973 O  O   . HOH M 9 .   ? -15.476 -22.395 -19.238 1.00 51.22  ? 1358 HOH A O   1 
HETATM 4974 O  O   . HOH M 9 .   ? -17.506 -71.927 -22.561 1.00 41.54  ? 1359 HOH A O   1 
HETATM 4975 O  O   . HOH M 9 .   ? -2.032  -34.128 -13.504 1.00 65.58  ? 1360 HOH A O   1 
HETATM 4976 O  O   . HOH M 9 .   ? 0.011   -46.055 -42.882 1.00 48.06  ? 1361 HOH A O   1 
HETATM 4977 O  O   . HOH M 9 .   ? -22.937 -75.874 -9.296  1.00 42.35  ? 1362 HOH A O   1 
HETATM 4978 O  O   . HOH M 9 .   ? -7.574  -62.589 -33.633 0.50 26.55  ? 1363 HOH A O   1 
HETATM 4979 O  O   . HOH M 9 .   ? -35.645 -51.385 -23.048 1.00 51.55  ? 1364 HOH A O   1 
HETATM 4980 O  O   . HOH M 9 .   ? -22.639 -29.738 -14.721 1.00 66.87  ? 1365 HOH A O   1 
HETATM 4981 O  O   . HOH M 9 .   ? -35.955 -61.093 -20.553 1.00 56.99  ? 1366 HOH A O   1 
HETATM 4982 O  O   . HOH M 9 .   ? -9.538  -32.512 -46.328 1.00 58.42  ? 1367 HOH A O   1 
HETATM 4983 O  O   . HOH M 9 .   ? -18.275 -69.747 -25.237 0.48 34.53  ? 1368 HOH A O   1 
HETATM 4984 O  O   . HOH M 9 .   ? -12.317 -76.185 -26.515 1.00 78.24  ? 1369 HOH A O   1 
HETATM 4985 O  O   . HOH M 9 .   ? -20.324 -38.395 -36.456 0.50 31.31  ? 1370 HOH A O   1 
HETATM 4986 O  O   . HOH M 9 .   ? -5.506  -59.442 -36.822 0.50 41.51  ? 1371 HOH A O   1 
HETATM 4987 O  O   . HOH M 9 .   ? -18.313 -47.175 -9.828  0.50 36.28  ? 1372 HOH A O   1 
HETATM 4988 O  O   . HOH M 9 .   ? 0.742   -31.822 -47.194 1.00 41.95  ? 1373 HOH A O   1 
HETATM 4989 O  O   . HOH M 9 .   ? -22.102 -31.836 -39.947 1.00 39.71  ? 1374 HOH A O   1 
HETATM 4990 O  O   . HOH M 9 .   ? -9.972  -38.920 -43.628 0.50 50.93  ? 1375 HOH A O   1 
HETATM 4991 O  O   . HOH M 9 .   ? -13.497 -33.009 -20.648 1.00 40.14  ? 1376 HOH A O   1 
HETATM 4992 O  O   . HOH M 9 .   ? -5.128  -34.664 -14.075 0.50 54.28  ? 1377 HOH A O   1 
HETATM 4993 O  O   . HOH M 9 .   ? -8.412  -31.543 -15.551 1.00 52.89  ? 1378 HOH A O   1 
HETATM 4994 O  O   . HOH M 9 .   ? -31.673 -13.520 -9.639  0.50 36.34  ? 1379 HOH A O   1 
HETATM 4995 O  O   . HOH M 9 .   ? -23.338 -47.973 -34.048 0.50 37.97  ? 1380 HOH A O   1 
HETATM 4996 O  O   . HOH M 9 .   ? -13.371 -46.076 -9.963  1.00 55.58  ? 1381 HOH A O   1 
HETATM 4997 O  O   . HOH M 9 .   ? -12.566 -70.535 -22.999 0.48 31.96  ? 1382 HOH A O   1 
HETATM 4998 O  O   . HOH M 9 .   ? -1.573  -70.582 -17.063 0.48 32.84  ? 1383 HOH A O   1 
HETATM 4999 O  O   . HOH M 9 .   ? -7.358  -30.446 -13.514 1.00 57.65  ? 1384 HOH A O   1 
HETATM 5000 O  O   . HOH M 9 .   ? -16.525 -47.577 -11.355 1.00 52.47  ? 1385 HOH A O   1 
HETATM 5001 O  O   . HOH M 9 .   ? -8.932  -36.392 -44.800 1.00 60.04  ? 1386 HOH A O   1 
HETATM 5002 O  O   . HOH M 9 .   ? -12.991 -69.213 -6.320  1.00 38.20  ? 1387 HOH A O   1 
HETATM 5003 O  O   . HOH M 9 .   ? -8.557  -17.686 -40.226 0.50 41.71  ? 1388 HOH A O   1 
HETATM 5004 O  O   . HOH M 9 .   ? -4.687  -54.283 -20.268 0.46 21.00  ? 1389 HOH A O   1 
HETATM 5005 O  O   . HOH M 9 .   ? -19.909 -44.185 -38.128 1.00 48.84  ? 1390 HOH A O   1 
HETATM 5006 O  O   . HOH M 9 .   ? -30.121 -33.892 -32.725 1.00 51.37  ? 1391 HOH A O   1 
HETATM 5007 O  O   . HOH M 9 .   ? -33.998 -50.001 -10.374 1.00 49.41  ? 1392 HOH A O   1 
HETATM 5008 O  O   . HOH M 9 .   ? -27.094 -74.526 -4.788  0.50 49.98  ? 1393 HOH A O   1 
HETATM 5009 O  O   . HOH M 9 .   ? -2.872  -56.197 -28.998 1.00 29.87  ? 1394 HOH A O   1 
HETATM 5010 O  O   . HOH M 9 .   ? -5.589  -74.735 -13.508 0.48 45.41  ? 1395 HOH A O   1 
HETATM 5011 O  O   . HOH M 9 .   ? -14.604 -12.856 -40.369 1.00 70.12  ? 1396 HOH A O   1 
HETATM 5012 O  O   . HOH M 9 .   ? -17.683 -47.722 -15.686 0.50 30.51  ? 1397 HOH A O   1 
HETATM 5013 O  O   . HOH M 9 .   ? -34.751 -50.119 -20.834 1.00 58.40  ? 1398 HOH A O   1 
HETATM 5014 O  O   . HOH M 9 .   ? -41.137 -58.708 -4.117  0.50 125.97 ? 1399 HOH A O   1 
HETATM 5015 O  O   . HOH M 9 .   ? -34.607 -70.548 -9.477  0.66 36.51  ? 1400 HOH A O   1 
HETATM 5016 O  O   . HOH M 9 .   ? -30.665 -17.012 -32.313 1.00 45.34  ? 1401 HOH A O   1 
HETATM 5017 O  O   . HOH M 9 .   ? -37.810 -52.638 -4.019  1.00 45.12  ? 1402 HOH A O   1 
HETATM 5018 O  O   . HOH M 9 .   ? 0.097   -62.722 -18.110 0.48 25.58  ? 1403 HOH A O   1 
HETATM 5019 O  O   . HOH M 9 .   ? -36.703 -65.258 0.175   1.00 45.87  ? 1404 HOH A O   1 
HETATM 5020 O  O   . HOH M 9 .   ? -2.981  -52.288 -15.887 1.00 57.67  ? 1405 HOH A O   1 
HETATM 5021 O  O   . HOH M 9 .   ? -5.508  -31.742 -48.207 1.00 44.55  ? 1406 HOH A O   1 
HETATM 5022 O  O   . HOH M 9 .   ? -15.581 -42.144 -38.707 1.00 36.48  ? 1407 HOH A O   1 
HETATM 5023 O  O   . HOH M 9 .   ? -18.002 -28.428 -44.756 1.00 51.53  ? 1408 HOH A O   1 
HETATM 5024 O  O   . HOH M 9 .   ? -10.652 -18.035 -40.849 1.00 47.80  ? 1409 HOH A O   1 
HETATM 5025 O  O   . HOH M 9 .   ? -26.389 -28.553 -43.492 0.50 31.70  ? 1410 HOH A O   1 
HETATM 5026 O  O   . HOH M 9 .   ? -4.621  -65.428 -30.906 1.00 50.39  ? 1411 HOH A O   1 
HETATM 5027 O  O   . HOH M 9 .   ? -42.298 -66.876 -9.424  1.00 57.40  ? 1412 HOH A O   1 
HETATM 5028 O  O   . HOH M 9 .   ? -7.349  -44.974 -16.605 0.50 34.09  ? 1413 HOH A O   1 
HETATM 5029 O  O   . HOH M 9 .   ? -24.871 -28.864 -22.827 1.00 50.94  ? 1414 HOH A O   1 
HETATM 5030 O  O   . HOH M 9 .   ? -28.455 -66.044 -42.160 1.00 45.16  ? 1415 HOH A O   1 
HETATM 5031 O  O   . HOH M 9 .   ? -24.149 -36.407 -35.365 1.00 45.22  ? 1416 HOH A O   1 
HETATM 5032 O  O   . HOH M 9 .   ? -30.928 -60.159 -34.504 1.00 49.30  ? 1417 HOH A O   1 
HETATM 5033 O  O   . HOH M 9 .   ? -1.673  -65.788 -15.696 1.00 49.04  ? 1418 HOH A O   1 
HETATM 5034 O  O   . HOH M 9 .   ? -10.045 -28.120 -12.004 1.00 57.90  ? 1419 HOH A O   1 
HETATM 5035 O  O   . HOH M 9 .   ? -25.355 -28.342 -20.107 1.00 50.90  ? 1420 HOH A O   1 
HETATM 5036 O  O   . HOH M 9 .   ? -27.993 -55.586 -41.429 0.50 34.38  ? 1421 HOH A O   1 
HETATM 5037 O  O   . HOH M 9 .   ? -15.538 -69.588 -6.060  1.00 25.90  ? 1422 HOH A O   1 
HETATM 5038 O  O   . HOH M 9 .   ? -15.692 -46.214 -19.630 1.00 60.62  ? 1423 HOH A O   1 
HETATM 5039 O  O   . HOH M 9 .   ? -35.759 -48.751 -14.125 1.00 50.49  ? 1424 HOH A O   1 
HETATM 5040 O  O   . HOH M 9 .   ? -41.318 -57.196 -13.646 1.00 29.36  ? 1425 HOH A O   1 
HETATM 5041 O  O   . HOH M 9 .   ? -25.609 -19.812 -38.921 0.50 30.39  ? 1426 HOH A O   1 
HETATM 5042 O  O   . HOH M 9 .   ? -1.083  -63.562 -15.497 1.00 54.03  ? 1427 HOH A O   1 
HETATM 5043 O  O   . HOH M 9 .   ? -21.650 -43.711 -42.046 0.50 43.94  ? 1428 HOH A O   1 
HETATM 5044 O  O   . HOH M 9 .   ? -19.011 -40.237 -38.960 0.50 28.82  ? 1429 HOH A O   1 
HETATM 5045 O  O   . HOH M 9 .   ? -0.966  -57.333 -32.510 0.50 41.90  ? 1430 HOH A O   1 
HETATM 5046 O  O   . HOH M 9 .   ? -3.270  -51.109 -18.048 1.00 45.63  ? 1431 HOH A O   1 
HETATM 5047 O  O   . HOH M 9 .   ? 0.000   -58.708 -28.639 0.50 28.21  ? 1432 HOH A O   1 
HETATM 5048 O  O   . HOH M 9 .   ? -16.477 -39.842 -39.777 0.50 47.36  ? 1433 HOH A O   1 
HETATM 5049 O  O   . HOH M 9 .   ? -9.053  -72.372 -26.198 0.48 31.12  ? 1434 HOH A O   1 
HETATM 5050 O  O   . HOH M 9 .   ? -3.007  -56.956 -34.022 1.00 49.50  ? 1435 HOH A O   1 
HETATM 5051 O  O   . HOH M 9 .   ? -8.061  -49.141 3.685   0.34 38.08  ? 1436 HOH A O   1 
HETATM 5052 O  O   . HOH M 9 .   ? -19.868 -68.823 -4.432  1.00 28.73  ? 1437 HOH A O   1 
HETATM 5053 O  O   . HOH M 9 .   ? -2.717  -59.953 -0.645  1.00 37.60  ? 1438 HOH A O   1 
HETATM 5054 O  O   . HOH M 9 .   ? -18.118 -68.369 -6.468  1.00 25.14  ? 1439 HOH A O   1 
HETATM 5055 O  O   . HOH M 9 .   ? -23.248 -40.504 -44.228 0.50 50.26  ? 1440 HOH A O   1 
HETATM 5056 O  O   . HOH M 9 .   ? -1.664  -60.075 -3.087  1.00 50.63  ? 1441 HOH A O   1 
HETATM 5057 O  O   A HOH M 9 .   ? -16.309 -74.076 -34.749 0.24 42.35  ? 1442 HOH A O   1 
HETATM 5058 O  O   B HOH M 9 .   ? -19.904 -74.850 -35.461 0.24 30.07  ? 1442 HOH A O   1 
HETATM 5059 O  O   . HOH M 9 .   ? -4.246  -61.314 -10.674 1.00 45.69  ? 1443 HOH A O   1 
HETATM 5060 O  O   . HOH M 9 .   ? -5.491  -64.583 -6.703  1.00 39.22  ? 1444 HOH A O   1 
HETATM 5061 O  O   . HOH M 9 .   ? -12.173 -37.294 -42.577 0.50 35.76  ? 1445 HOH A O   1 
HETATM 5062 O  O   . HOH M 9 .   ? -13.539 -70.667 -26.191 0.48 52.32  ? 1446 HOH A O   1 
HETATM 5063 O  O   . HOH M 9 .   ? 10.273  -21.158 -26.224 1.00 52.08  ? 1447 HOH A O   1 
HETATM 5064 O  O   . HOH M 9 .   ? 13.240  -24.995 -25.973 0.50 57.20  ? 1448 HOH A O   1 
HETATM 5065 O  O   . HOH M 9 .   ? -42.773 -62.490 -2.357  0.50 51.77  ? 1449 HOH A O   1 
HETATM 5066 O  O   . HOH M 9 .   ? -1.224  -55.618 -0.900  1.00 47.03  ? 1450 HOH A O   1 
HETATM 5067 O  O   . HOH M 9 .   ? -41.137 -61.001 0.000   0.50 103.26 ? 1451 HOH A O   1 
HETATM 5068 O  O   . HOH M 9 .   ? -4.035  -63.084 -9.093  1.00 49.34  ? 1452 HOH A O   1 
# 
