data_7I28
# 
_entry.id   7I28 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   7I28         pdb_00007i28 10.2210/pdb7i28/pdb 
WWPDB D_1001408223 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-02 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.entry_id                        7I28 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.recvd_initial_deposition_date   2025-03-06 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.SG_entry                        ? 
_pdbx_database_status.pdb_format_compatible           Y 
_pdbx_database_status.methods_development_category    ? 
# 
_pdbx_contact_author.id                 1 
_pdbx_contact_author.email              fr193@cabm.rutgers.edu 
_pdbx_contact_author.name_first         'Francesc Xavier' 
_pdbx_contact_author.name_last          Ruiz 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-0457-0030 
_pdbx_contact_author.name_mi            ? 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Aschenbrenner, J.C.' 1  ? 
'Saini, M.'           2  ? 
'Chopra, A.'          3  ? 
'Marples, P.G.'       4  ? 
'Balcomb, B.H.'       5  ? 
'Lithgo, R.M.'        6  ? 
'Fearon, D.'          7  ? 
'von Delft, F.'       8  ? 
'Ruiz, F.X.'          9  ? 
'Arnold, E.'          10 ? 
# 
_citation.id                        primary 
_citation.title                     
'Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_volume            ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.year                      ? 
_citation.journal_id_ASTM           ? 
_citation.country                   ? 
_citation.journal_id_ISSN           ? 
_citation.journal_id_CSD            0353 
_citation.book_publisher            ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_DOI      ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.identifier_ORCID 
_citation_author.ordinal 
primary 'Aschenbrenner, J.C.' ? 1  
primary 'Saini, M.'           ? 2  
primary 'Chopra, A.'          ? 3  
primary 'Marples, P.G.'       ? 4  
primary 'Balcomb, B.H.'       ? 5  
primary 'Lithgo, R.M.'        ? 6  
primary 'Fearon, D.'          ? 7  
primary 'von Delft, F.'       ? 8  
primary 'Ruiz, F.X.'          ? 9  
primary 'Arnold, E.'          ? 10 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'NS5 RNA-dependent RNA polymerase'     73890.008 1   ? ? ? ? 
2 non-polymer syn 'ZINC ION'                             65.409    2   ? ? ? ? 
3 non-polymer syn '2-(N-MORPHOLINO)-ETHANESULFONIC ACID' 195.237   1   ? ? ? ? 
4 non-polymer syn 'DIMETHYL SULFOXIDE'                   78.133    2   ? ? ? ? 
5 non-polymer syn 'DI(HYDROXYETHYL)ETHER'                106.120   2   ? ? ? ? 
6 non-polymer syn 'PHOSPHATE ION'                        94.971    2   ? ? ? ? 
7 non-polymer syn 2-chloro-N-methylbenzene-1-sulfonamide 205.662   2   ? ? ? ? 
8 non-polymer syn 'CHLORIDE ION'                         35.453    1   ? ? ? ? 
9 water       nat water                                  18.015    290 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;GPGIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAM
TDTTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAR
EAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENS
LSGVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRP
TPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGD
DCVVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQG
AGWSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPW
MEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_entity_poly.pdbx_seq_one_letter_code_can   
;GPGIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAM
TDTTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAR
EAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENS
LSGVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRP
TPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGD
DCVVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQG
AGWSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPW
MEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'ZINC ION'                             ZN  
3 '2-(N-MORPHOLINO)-ETHANESULFONIC ACID' MES 
4 'DIMETHYL SULFOXIDE'                   DMS 
5 'DI(HYDROXYETHYL)ETHER'                PEG 
6 'PHOSPHATE ION'                        PO4 
7 2-chloro-N-methylbenzene-1-sulfonamide X0S 
8 'CHLORIDE ION'                         CL  
9 water                                  HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   PRO n 
1 3   GLY n 
1 4   ILE n 
1 5   GLU n 
1 6   SER n 
1 7   GLU n 
1 8   THR n 
1 9   PRO n 
1 10  ASN n 
1 11  LEU n 
1 12  ASP n 
1 13  ILE n 
1 14  ILE n 
1 15  GLY n 
1 16  LYS n 
1 17  ARG n 
1 18  ILE n 
1 19  GLU n 
1 20  LYS n 
1 21  ILE n 
1 22  LYS n 
1 23  GLN n 
1 24  GLU n 
1 25  HIS n 
1 26  GLU n 
1 27  THR n 
1 28  SER n 
1 29  TRP n 
1 30  HIS n 
1 31  TYR n 
1 32  ASP n 
1 33  GLN n 
1 34  ASP n 
1 35  HIS n 
1 36  PRO n 
1 37  TYR n 
1 38  LYS n 
1 39  THR n 
1 40  TRP n 
1 41  ALA n 
1 42  TYR n 
1 43  HIS n 
1 44  GLY n 
1 45  SER n 
1 46  TYR n 
1 47  GLU n 
1 48  THR n 
1 49  LYS n 
1 50  GLN n 
1 51  THR n 
1 52  GLY n 
1 53  SER n 
1 54  ALA n 
1 55  SER n 
1 56  SER n 
1 57  MET n 
1 58  VAL n 
1 59  ASN n 
1 60  GLY n 
1 61  VAL n 
1 62  VAL n 
1 63  ARG n 
1 64  LEU n 
1 65  LEU n 
1 66  THR n 
1 67  LYS n 
1 68  PRO n 
1 69  TRP n 
1 70  ASP n 
1 71  ILE n 
1 72  ILE n 
1 73  PRO n 
1 74  MET n 
1 75  VAL n 
1 76  THR n 
1 77  GLN n 
1 78  MET n 
1 79  ALA n 
1 80  MET n 
1 81  THR n 
1 82  ASP n 
1 83  THR n 
1 84  THR n 
1 85  PRO n 
1 86  PHE n 
1 87  GLY n 
1 88  GLN n 
1 89  GLN n 
1 90  ARG n 
1 91  VAL n 
1 92  PHE n 
1 93  LYS n 
1 94  GLU n 
1 95  LYS n 
1 96  VAL n 
1 97  ASP n 
1 98  THR n 
1 99  ARG n 
1 100 THR n 
1 101 GLN n 
1 102 GLU n 
1 103 PRO n 
1 104 LYS n 
1 105 GLU n 
1 106 GLY n 
1 107 THR n 
1 108 LYS n 
1 109 LYS n 
1 110 LEU n 
1 111 MET n 
1 112 LYS n 
1 113 ILE n 
1 114 THR n 
1 115 ALA n 
1 116 GLU n 
1 117 TRP n 
1 118 LEU n 
1 119 TRP n 
1 120 LYS n 
1 121 GLU n 
1 122 LEU n 
1 123 GLY n 
1 124 LYS n 
1 125 LYS n 
1 126 LYS n 
1 127 THR n 
1 128 PRO n 
1 129 ARG n 
1 130 MET n 
1 131 CYS n 
1 132 THR n 
1 133 ARG n 
1 134 GLU n 
1 135 GLU n 
1 136 PHE n 
1 137 THR n 
1 138 ARG n 
1 139 LYS n 
1 140 VAL n 
1 141 ARG n 
1 142 SER n 
1 143 ASN n 
1 144 ALA n 
1 145 ALA n 
1 146 LEU n 
1 147 GLY n 
1 148 ALA n 
1 149 ILE n 
1 150 PHE n 
1 151 THR n 
1 152 ASP n 
1 153 GLU n 
1 154 ASN n 
1 155 LYS n 
1 156 TRP n 
1 157 LYS n 
1 158 SER n 
1 159 ALA n 
1 160 ARG n 
1 161 GLU n 
1 162 ALA n 
1 163 VAL n 
1 164 GLU n 
1 165 ASP n 
1 166 SER n 
1 167 GLY n 
1 168 PHE n 
1 169 TRP n 
1 170 GLU n 
1 171 LEU n 
1 172 VAL n 
1 173 ASP n 
1 174 LYS n 
1 175 GLU n 
1 176 ARG n 
1 177 ASN n 
1 178 LEU n 
1 179 HIS n 
1 180 LEU n 
1 181 GLU n 
1 182 GLY n 
1 183 LYS n 
1 184 CYS n 
1 185 GLU n 
1 186 THR n 
1 187 CYS n 
1 188 VAL n 
1 189 TYR n 
1 190 ASN n 
1 191 MET n 
1 192 MET n 
1 193 GLY n 
1 194 LYS n 
1 195 ARG n 
1 196 GLU n 
1 197 LYS n 
1 198 LYS n 
1 199 LEU n 
1 200 GLY n 
1 201 GLU n 
1 202 PHE n 
1 203 GLY n 
1 204 LYS n 
1 205 ALA n 
1 206 LYS n 
1 207 GLY n 
1 208 SER n 
1 209 ARG n 
1 210 ALA n 
1 211 ILE n 
1 212 TRP n 
1 213 TYR n 
1 214 MET n 
1 215 TRP n 
1 216 LEU n 
1 217 GLY n 
1 218 ALA n 
1 219 ARG n 
1 220 PHE n 
1 221 LEU n 
1 222 GLU n 
1 223 PHE n 
1 224 GLU n 
1 225 ALA n 
1 226 LEU n 
1 227 GLY n 
1 228 PHE n 
1 229 LEU n 
1 230 ASN n 
1 231 GLU n 
1 232 ASP n 
1 233 HIS n 
1 234 TRP n 
1 235 PHE n 
1 236 SER n 
1 237 ARG n 
1 238 GLU n 
1 239 ASN n 
1 240 SER n 
1 241 LEU n 
1 242 SER n 
1 243 GLY n 
1 244 VAL n 
1 245 GLU n 
1 246 GLY n 
1 247 GLU n 
1 248 GLY n 
1 249 LEU n 
1 250 HIS n 
1 251 LYS n 
1 252 LEU n 
1 253 GLY n 
1 254 TYR n 
1 255 ILE n 
1 256 LEU n 
1 257 ARG n 
1 258 ASP n 
1 259 VAL n 
1 260 SER n 
1 261 LYS n 
1 262 LYS n 
1 263 GLU n 
1 264 GLY n 
1 265 GLY n 
1 266 ALA n 
1 267 MET n 
1 268 TYR n 
1 269 ALA n 
1 270 ASP n 
1 271 ASP n 
1 272 THR n 
1 273 ALA n 
1 274 GLY n 
1 275 TRP n 
1 276 ASP n 
1 277 THR n 
1 278 ARG n 
1 279 ILE n 
1 280 THR n 
1 281 LEU n 
1 282 GLU n 
1 283 ASP n 
1 284 LEU n 
1 285 LYS n 
1 286 ASN n 
1 287 GLU n 
1 288 GLU n 
1 289 MET n 
1 290 VAL n 
1 291 THR n 
1 292 ASN n 
1 293 HIS n 
1 294 MET n 
1 295 GLU n 
1 296 GLY n 
1 297 GLU n 
1 298 HIS n 
1 299 LYS n 
1 300 LYS n 
1 301 LEU n 
1 302 ALA n 
1 303 GLU n 
1 304 ALA n 
1 305 ILE n 
1 306 PHE n 
1 307 LYS n 
1 308 LEU n 
1 309 THR n 
1 310 TYR n 
1 311 GLN n 
1 312 ASN n 
1 313 LYS n 
1 314 VAL n 
1 315 VAL n 
1 316 ARG n 
1 317 VAL n 
1 318 GLN n 
1 319 ARG n 
1 320 PRO n 
1 321 THR n 
1 322 PRO n 
1 323 ARG n 
1 324 GLY n 
1 325 THR n 
1 326 VAL n 
1 327 MET n 
1 328 ASP n 
1 329 ILE n 
1 330 ILE n 
1 331 SER n 
1 332 ARG n 
1 333 ARG n 
1 334 ASP n 
1 335 GLN n 
1 336 ARG n 
1 337 GLY n 
1 338 SER n 
1 339 GLY n 
1 340 GLN n 
1 341 VAL n 
1 342 VAL n 
1 343 THR n 
1 344 TYR n 
1 345 GLY n 
1 346 LEU n 
1 347 ASN n 
1 348 THR n 
1 349 PHE n 
1 350 THR n 
1 351 ASN n 
1 352 MET n 
1 353 GLU n 
1 354 ALA n 
1 355 GLN n 
1 356 LEU n 
1 357 ILE n 
1 358 ARG n 
1 359 GLN n 
1 360 MET n 
1 361 GLU n 
1 362 GLY n 
1 363 GLU n 
1 364 GLY n 
1 365 VAL n 
1 366 PHE n 
1 367 LYS n 
1 368 SER n 
1 369 ILE n 
1 370 GLN n 
1 371 HIS n 
1 372 LEU n 
1 373 THR n 
1 374 VAL n 
1 375 THR n 
1 376 GLU n 
1 377 GLU n 
1 378 ILE n 
1 379 ALA n 
1 380 VAL n 
1 381 LYS n 
1 382 ASN n 
1 383 TRP n 
1 384 LEU n 
1 385 VAL n 
1 386 ARG n 
1 387 VAL n 
1 388 GLY n 
1 389 ARG n 
1 390 GLU n 
1 391 ARG n 
1 392 LEU n 
1 393 SER n 
1 394 ARG n 
1 395 MET n 
1 396 ALA n 
1 397 ILE n 
1 398 SER n 
1 399 GLY n 
1 400 ASP n 
1 401 ASP n 
1 402 CYS n 
1 403 VAL n 
1 404 VAL n 
1 405 LYS n 
1 406 PRO n 
1 407 LEU n 
1 408 ASP n 
1 409 ASP n 
1 410 ARG n 
1 411 PHE n 
1 412 ALA n 
1 413 SER n 
1 414 ALA n 
1 415 LEU n 
1 416 THR n 
1 417 ALA n 
1 418 LEU n 
1 419 ASN n 
1 420 ASP n 
1 421 MET n 
1 422 GLY n 
1 423 LYS n 
1 424 VAL n 
1 425 ARG n 
1 426 LYS n 
1 427 ASP n 
1 428 ILE n 
1 429 GLN n 
1 430 GLN n 
1 431 TRP n 
1 432 GLU n 
1 433 PRO n 
1 434 SER n 
1 435 ARG n 
1 436 GLY n 
1 437 TRP n 
1 438 ASN n 
1 439 ASP n 
1 440 TRP n 
1 441 THR n 
1 442 GLN n 
1 443 VAL n 
1 444 PRO n 
1 445 PHE n 
1 446 CYS n 
1 447 SER n 
1 448 HIS n 
1 449 HIS n 
1 450 PHE n 
1 451 HIS n 
1 452 GLU n 
1 453 LEU n 
1 454 ILE n 
1 455 MET n 
1 456 LYS n 
1 457 ASP n 
1 458 GLY n 
1 459 ARG n 
1 460 VAL n 
1 461 LEU n 
1 462 VAL n 
1 463 VAL n 
1 464 PRO n 
1 465 CYS n 
1 466 ARG n 
1 467 ASN n 
1 468 GLN n 
1 469 ASP n 
1 470 GLU n 
1 471 LEU n 
1 472 ILE n 
1 473 GLY n 
1 474 ARG n 
1 475 ALA n 
1 476 ARG n 
1 477 ILE n 
1 478 SER n 
1 479 GLN n 
1 480 GLY n 
1 481 ALA n 
1 482 GLY n 
1 483 TRP n 
1 484 SER n 
1 485 LEU n 
1 486 ARG n 
1 487 GLU n 
1 488 THR n 
1 489 ALA n 
1 490 CYS n 
1 491 LEU n 
1 492 GLY n 
1 493 LYS n 
1 494 SER n 
1 495 TYR n 
1 496 ALA n 
1 497 GLN n 
1 498 MET n 
1 499 TRP n 
1 500 SER n 
1 501 LEU n 
1 502 MET n 
1 503 TYR n 
1 504 PHE n 
1 505 HIS n 
1 506 ARG n 
1 507 ARG n 
1 508 ASP n 
1 509 LEU n 
1 510 ARG n 
1 511 LEU n 
1 512 ALA n 
1 513 ALA n 
1 514 ASN n 
1 515 ALA n 
1 516 ILE n 
1 517 CYS n 
1 518 SER n 
1 519 ALA n 
1 520 VAL n 
1 521 PRO n 
1 522 SER n 
1 523 HIS n 
1 524 TRP n 
1 525 VAL n 
1 526 PRO n 
1 527 THR n 
1 528 SER n 
1 529 ARG n 
1 530 THR n 
1 531 THR n 
1 532 TRP n 
1 533 SER n 
1 534 ILE n 
1 535 HIS n 
1 536 ALA n 
1 537 THR n 
1 538 HIS n 
1 539 GLU n 
1 540 TRP n 
1 541 MET n 
1 542 THR n 
1 543 THR n 
1 544 GLU n 
1 545 ASP n 
1 546 MET n 
1 547 LEU n 
1 548 THR n 
1 549 VAL n 
1 550 TRP n 
1 551 ASN n 
1 552 ARG n 
1 553 VAL n 
1 554 TRP n 
1 555 ILE n 
1 556 GLN n 
1 557 GLU n 
1 558 ASN n 
1 559 PRO n 
1 560 TRP n 
1 561 MET n 
1 562 GLU n 
1 563 ASP n 
1 564 LYS n 
1 565 THR n 
1 566 PRO n 
1 567 VAL n 
1 568 GLU n 
1 569 SER n 
1 570 TRP n 
1 571 GLU n 
1 572 GLU n 
1 573 ILE n 
1 574 PRO n 
1 575 TYR n 
1 576 LEU n 
1 577 GLY n 
1 578 LYS n 
1 579 ARG n 
1 580 GLU n 
1 581 ASP n 
1 582 GLN n 
1 583 TRP n 
1 584 CYS n 
1 585 GLY n 
1 586 SER n 
1 587 LEU n 
1 588 ILE n 
1 589 GLY n 
1 590 LEU n 
1 591 THR n 
1 592 SER n 
1 593 ARG n 
1 594 ALA n 
1 595 THR n 
1 596 TRP n 
1 597 ALA n 
1 598 LYS n 
1 599 ASN n 
1 600 ILE n 
1 601 GLN n 
1 602 THR n 
1 603 ALA n 
1 604 ILE n 
1 605 ASN n 
1 606 GLN n 
1 607 VAL n 
1 608 ARG n 
1 609 SER n 
1 610 LEU n 
1 611 ILE n 
1 612 GLY n 
1 613 ASN n 
1 614 GLU n 
1 615 GLU n 
1 616 TYR n 
1 617 THR n 
1 618 ASP n 
1 619 TYR n 
1 620 MET n 
1 621 PRO n 
1 622 SER n 
1 623 MET n 
1 624 LYS n 
1 625 ARG n 
1 626 PHE n 
1 627 ARG n 
1 628 ARG n 
1 629 GLU n 
1 630 GLU n 
1 631 GLU n 
1 632 GLU n 
1 633 ALA n 
1 634 GLY n 
1 635 VAL n 
1 636 LEU n 
1 637 TRP n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   637 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'dengue virus type 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     11060 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                ? 'C3 H7 N O2'      89.093  
ARG 'L-peptide linking' y ARGININE                               ? 'C6 H15 N4 O2 1'  175.209 
ASN 'L-peptide linking' y ASPARAGINE                             ? 'C4 H8 N2 O3'     132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                        ? 'C4 H7 N O4'      133.103 
CL  non-polymer         . 'CHLORIDE ION'                         ? 'Cl -1'           35.453  
CYS 'L-peptide linking' y CYSTEINE                               ? 'C3 H7 N O2 S'    121.158 
DMS non-polymer         . 'DIMETHYL SULFOXIDE'                   ? 'C2 H6 O S'       78.133  
GLN 'L-peptide linking' y GLUTAMINE                              ? 'C5 H10 N2 O3'    146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                        ? 'C5 H9 N O4'      147.129 
GLY 'peptide linking'   y GLYCINE                                ? 'C2 H5 N O2'      75.067  
HIS 'L-peptide linking' y HISTIDINE                              ? 'C6 H10 N3 O2 1'  156.162 
HOH non-polymer         . WATER                                  ? 'H2 O'            18.015  
ILE 'L-peptide linking' y ISOLEUCINE                             ? 'C6 H13 N O2'     131.173 
LEU 'L-peptide linking' y LEUCINE                                ? 'C6 H13 N O2'     131.173 
LYS 'L-peptide linking' y LYSINE                                 ? 'C6 H15 N2 O2 1'  147.195 
MES non-polymer         . '2-(N-MORPHOLINO)-ETHANESULFONIC ACID' ? 'C6 H13 N O4 S'   195.237 
MET 'L-peptide linking' y METHIONINE                             ? 'C5 H11 N O2 S'   149.211 
PEG non-polymer         . 'DI(HYDROXYETHYL)ETHER'                ? 'C4 H10 O3'       106.120 
PHE 'L-peptide linking' y PHENYLALANINE                          ? 'C9 H11 N O2'     165.189 
PO4 non-polymer         . 'PHOSPHATE ION'                        ? 'O4 P -3'         94.971  
PRO 'L-peptide linking' y PROLINE                                ? 'C5 H9 N O2'      115.130 
SER 'L-peptide linking' y SERINE                                 ? 'C3 H7 N O3'      105.093 
THR 'L-peptide linking' y THREONINE                              ? 'C4 H9 N O3'      119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                             ? 'C11 H12 N2 O2'   204.225 
TYR 'L-peptide linking' y TYROSINE                               ? 'C9 H11 N O3'     181.189 
VAL 'L-peptide linking' y VALINE                                 ? 'C5 H11 N O2'     117.146 
X0S non-polymer         . 2-chloro-N-methylbenzene-1-sulfonamide ? 'C7 H8 Cl N O2 S' 205.662 
ZN  non-polymer         . 'ZINC ION'                             ? 'Zn 2'            65.409  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   264 ?   ?   ?   A . n 
A 1 2   PRO 2   265 ?   ?   ?   A . n 
A 1 3   GLY 3   266 ?   ?   ?   A . n 
A 1 4   ILE 4   267 ?   ?   ?   A . n 
A 1 5   GLU 5   268 ?   ?   ?   A . n 
A 1 6   SER 6   269 ?   ?   ?   A . n 
A 1 7   GLU 7   270 ?   ?   ?   A . n 
A 1 8   THR 8   271 ?   ?   ?   A . n 
A 1 9   PRO 9   272 ?   ?   ?   A . n 
A 1 10  ASN 10  273 273 ASN ASN A . n 
A 1 11  LEU 11  274 274 LEU LEU A . n 
A 1 12  ASP 12  275 275 ASP ASP A . n 
A 1 13  ILE 13  276 276 ILE ILE A . n 
A 1 14  ILE 14  277 277 ILE ILE A . n 
A 1 15  GLY 15  278 278 GLY GLY A . n 
A 1 16  LYS 16  279 279 LYS LYS A . n 
A 1 17  ARG 17  280 280 ARG ARG A . n 
A 1 18  ILE 18  281 281 ILE ILE A . n 
A 1 19  GLU 19  282 282 GLU GLU A . n 
A 1 20  LYS 20  283 283 LYS LYS A . n 
A 1 21  ILE 21  284 284 ILE ILE A . n 
A 1 22  LYS 22  285 285 LYS LYS A . n 
A 1 23  GLN 23  286 286 GLN GLN A . n 
A 1 24  GLU 24  287 287 GLU GLU A . n 
A 1 25  HIS 25  288 288 HIS HIS A . n 
A 1 26  GLU 26  289 289 GLU GLU A . n 
A 1 27  THR 27  290 290 THR THR A . n 
A 1 28  SER 28  291 291 SER SER A . n 
A 1 29  TRP 29  292 292 TRP TRP A . n 
A 1 30  HIS 30  293 293 HIS HIS A . n 
A 1 31  TYR 31  294 294 TYR TYR A . n 
A 1 32  ASP 32  295 295 ASP ASP A . n 
A 1 33  GLN 33  296 296 GLN GLN A . n 
A 1 34  ASP 34  297 297 ASP ASP A . n 
A 1 35  HIS 35  298 298 HIS HIS A . n 
A 1 36  PRO 36  299 299 PRO PRO A . n 
A 1 37  TYR 37  300 300 TYR TYR A . n 
A 1 38  LYS 38  301 301 LYS LYS A . n 
A 1 39  THR 39  302 302 THR THR A . n 
A 1 40  TRP 40  303 303 TRP TRP A . n 
A 1 41  ALA 41  304 304 ALA ALA A . n 
A 1 42  TYR 42  305 305 TYR TYR A . n 
A 1 43  HIS 43  306 306 HIS HIS A . n 
A 1 44  GLY 44  307 307 GLY GLY A . n 
A 1 45  SER 45  308 308 SER SER A . n 
A 1 46  TYR 46  309 309 TYR TYR A . n 
A 1 47  GLU 47  310 310 GLU GLU A . n 
A 1 48  THR 48  311 311 THR THR A . n 
A 1 49  LYS 49  312 ?   ?   ?   A . n 
A 1 50  GLN 50  313 ?   ?   ?   A . n 
A 1 51  THR 51  314 ?   ?   ?   A . n 
A 1 52  GLY 52  315 ?   ?   ?   A . n 
A 1 53  SER 53  316 ?   ?   ?   A . n 
A 1 54  ALA 54  317 317 ALA ALA A . n 
A 1 55  SER 55  318 318 SER SER A . n 
A 1 56  SER 56  319 319 SER SER A . n 
A 1 57  MET 57  320 320 MET MET A . n 
A 1 58  VAL 58  321 321 VAL VAL A . n 
A 1 59  ASN 59  322 322 ASN ASN A . n 
A 1 60  GLY 60  323 323 GLY GLY A . n 
A 1 61  VAL 61  324 324 VAL VAL A . n 
A 1 62  VAL 62  325 325 VAL VAL A . n 
A 1 63  ARG 63  326 326 ARG ARG A . n 
A 1 64  LEU 64  327 327 LEU LEU A . n 
A 1 65  LEU 65  328 328 LEU LEU A . n 
A 1 66  THR 66  329 329 THR THR A . n 
A 1 67  LYS 67  330 330 LYS LYS A . n 
A 1 68  PRO 68  331 331 PRO PRO A . n 
A 1 69  TRP 69  332 332 TRP TRP A . n 
A 1 70  ASP 70  333 333 ASP ASP A . n 
A 1 71  ILE 71  334 334 ILE ILE A . n 
A 1 72  ILE 72  335 335 ILE ILE A . n 
A 1 73  PRO 73  336 336 PRO PRO A . n 
A 1 74  MET 74  337 337 MET MET A . n 
A 1 75  VAL 75  338 338 VAL VAL A . n 
A 1 76  THR 76  339 339 THR THR A . n 
A 1 77  GLN 77  340 340 GLN GLN A . n 
A 1 78  MET 78  341 341 MET MET A . n 
A 1 79  ALA 79  342 342 ALA ALA A . n 
A 1 80  MET 80  343 343 MET MET A . n 
A 1 81  THR 81  344 344 THR GLY A . n 
A 1 82  ASP 82  345 ?   ?   ?   A . n 
A 1 83  THR 83  346 ?   ?   ?   A . n 
A 1 84  THR 84  347 ?   ?   ?   A . n 
A 1 85  PRO 85  348 ?   ?   ?   A . n 
A 1 86  PHE 86  349 ?   ?   ?   A . n 
A 1 87  GLY 87  350 ?   ?   ?   A . n 
A 1 88  GLN 88  351 ?   ?   ?   A . n 
A 1 89  GLN 89  352 ?   ?   ?   A . n 
A 1 90  ARG 90  353 ?   ?   ?   A . n 
A 1 91  VAL 91  354 ?   ?   ?   A . n 
A 1 92  PHE 92  355 ?   ?   ?   A . n 
A 1 93  LYS 93  356 ?   ?   ?   A . n 
A 1 94  GLU 94  357 357 GLU GLU A . n 
A 1 95  LYS 95  358 358 LYS LYS A . n 
A 1 96  VAL 96  359 359 VAL VAL A . n 
A 1 97  ASP 97  360 360 ASP ASP A . n 
A 1 98  THR 98  361 361 THR THR A . n 
A 1 99  ARG 99  362 362 ARG ARG A . n 
A 1 100 THR 100 363 363 THR THR A . n 
A 1 101 GLN 101 364 364 GLN GLN A . n 
A 1 102 GLU 102 365 365 GLU GLU A . n 
A 1 103 PRO 103 366 366 PRO PRO A . n 
A 1 104 LYS 104 367 367 LYS LYS A . n 
A 1 105 GLU 105 368 368 GLU GLU A . n 
A 1 106 GLY 106 369 369 GLY GLY A . n 
A 1 107 THR 107 370 370 THR THR A . n 
A 1 108 LYS 108 371 371 LYS LYS A . n 
A 1 109 LYS 109 372 372 LYS LYS A . n 
A 1 110 LEU 110 373 373 LEU LEU A . n 
A 1 111 MET 111 374 374 MET MET A . n 
A 1 112 LYS 112 375 375 LYS LYS A . n 
A 1 113 ILE 113 376 376 ILE ILE A . n 
A 1 114 THR 114 377 377 THR THR A . n 
A 1 115 ALA 115 378 378 ALA ALA A . n 
A 1 116 GLU 116 379 379 GLU GLU A . n 
A 1 117 TRP 117 380 380 TRP TRP A . n 
A 1 118 LEU 118 381 381 LEU LEU A . n 
A 1 119 TRP 119 382 382 TRP TRP A . n 
A 1 120 LYS 120 383 383 LYS LYS A . n 
A 1 121 GLU 121 384 384 GLU GLU A . n 
A 1 122 LEU 122 385 385 LEU LEU A . n 
A 1 123 GLY 123 386 386 GLY GLY A . n 
A 1 124 LYS 124 387 387 LYS LYS A . n 
A 1 125 LYS 125 388 388 LYS LYS A . n 
A 1 126 LYS 126 389 389 LYS LYS A . n 
A 1 127 THR 127 390 390 THR THR A . n 
A 1 128 PRO 128 391 391 PRO PRO A . n 
A 1 129 ARG 129 392 392 ARG ARG A . n 
A 1 130 MET 130 393 393 MET MET A . n 
A 1 131 CYS 131 394 394 CYS CYS A . n 
A 1 132 THR 132 395 395 THR THR A . n 
A 1 133 ARG 133 396 396 ARG ARG A . n 
A 1 134 GLU 134 397 397 GLU GLU A . n 
A 1 135 GLU 135 398 398 GLU GLU A . n 
A 1 136 PHE 136 399 399 PHE PHE A . n 
A 1 137 THR 137 400 400 THR THR A . n 
A 1 138 ARG 138 401 401 ARG ARG A . n 
A 1 139 LYS 139 402 402 LYS LYS A . n 
A 1 140 VAL 140 403 403 VAL VAL A . n 
A 1 141 ARG 141 404 404 ARG ARG A . n 
A 1 142 SER 142 405 405 SER SER A . n 
A 1 143 ASN 143 406 406 ASN ASN A . n 
A 1 144 ALA 144 407 407 ALA ALA A . n 
A 1 145 ALA 145 408 408 ALA ALA A . n 
A 1 146 LEU 146 409 409 LEU LEU A . n 
A 1 147 GLY 147 410 410 GLY GLY A . n 
A 1 148 ALA 148 411 411 ALA ALA A . n 
A 1 149 ILE 149 412 412 ILE ILE A . n 
A 1 150 PHE 150 413 ?   ?   ?   A . n 
A 1 151 THR 151 414 ?   ?   ?   A . n 
A 1 152 ASP 152 415 ?   ?   ?   A . n 
A 1 153 GLU 153 416 ?   ?   ?   A . n 
A 1 154 ASN 154 417 ?   ?   ?   A . n 
A 1 155 LYS 155 418 ?   ?   ?   A . n 
A 1 156 TRP 156 419 419 TRP TRP A . n 
A 1 157 LYS 157 420 420 LYS LYS A . n 
A 1 158 SER 158 421 421 SER SER A . n 
A 1 159 ALA 159 422 422 ALA ALA A . n 
A 1 160 ARG 160 423 423 ARG ARG A . n 
A 1 161 GLU 161 424 424 GLU GLU A . n 
A 1 162 ALA 162 425 425 ALA ALA A . n 
A 1 163 VAL 163 426 426 VAL VAL A . n 
A 1 164 GLU 164 427 427 GLU GLU A . n 
A 1 165 ASP 165 428 428 ASP ASP A . n 
A 1 166 SER 166 429 429 SER SER A . n 
A 1 167 GLY 167 430 430 GLY GLY A . n 
A 1 168 PHE 168 431 431 PHE PHE A . n 
A 1 169 TRP 169 432 432 TRP TRP A . n 
A 1 170 GLU 170 433 433 GLU GLU A . n 
A 1 171 LEU 171 434 434 LEU LEU A . n 
A 1 172 VAL 172 435 435 VAL VAL A . n 
A 1 173 ASP 173 436 436 ASP ASP A . n 
A 1 174 LYS 174 437 437 LYS LYS A . n 
A 1 175 GLU 175 438 438 GLU GLU A . n 
A 1 176 ARG 176 439 439 ARG ARG A . n 
A 1 177 ASN 177 440 440 ASN ASN A . n 
A 1 178 LEU 178 441 441 LEU LEU A . n 
A 1 179 HIS 179 442 442 HIS HIS A . n 
A 1 180 LEU 180 443 443 LEU LEU A . n 
A 1 181 GLU 181 444 444 GLU GLU A . n 
A 1 182 GLY 182 445 445 GLY GLY A . n 
A 1 183 LYS 183 446 446 LYS LYS A . n 
A 1 184 CYS 184 447 447 CYS CYS A . n 
A 1 185 GLU 185 448 448 GLU GLU A . n 
A 1 186 THR 186 449 449 THR THR A . n 
A 1 187 CYS 187 450 450 CYS CYS A . n 
A 1 188 VAL 188 451 451 VAL VAL A . n 
A 1 189 TYR 189 452 452 TYR TYR A . n 
A 1 190 ASN 190 453 453 ASN ASN A . n 
A 1 191 MET 191 454 454 MET MET A . n 
A 1 192 MET 192 455 455 MET MET A . n 
A 1 193 GLY 193 456 ?   ?   ?   A . n 
A 1 194 LYS 194 457 ?   ?   ?   A . n 
A 1 195 ARG 195 458 ?   ?   ?   A . n 
A 1 196 GLU 196 459 ?   ?   ?   A . n 
A 1 197 LYS 197 460 ?   ?   ?   A . n 
A 1 198 LYS 198 461 ?   ?   ?   A . n 
A 1 199 LEU 199 462 ?   ?   ?   A . n 
A 1 200 GLY 200 463 ?   ?   ?   A . n 
A 1 201 GLU 201 464 ?   ?   ?   A . n 
A 1 202 PHE 202 465 ?   ?   ?   A . n 
A 1 203 GLY 203 466 ?   ?   ?   A . n 
A 1 204 LYS 204 467 ?   ?   ?   A . n 
A 1 205 ALA 205 468 ?   ?   ?   A . n 
A 1 206 LYS 206 469 ?   ?   ?   A . n 
A 1 207 GLY 207 470 ?   ?   ?   A . n 
A 1 208 SER 208 471 ?   ?   ?   A . n 
A 1 209 ARG 209 472 ?   ?   ?   A . n 
A 1 210 ALA 210 473 473 ALA ALA A . n 
A 1 211 ILE 211 474 474 ILE ILE A . n 
A 1 212 TRP 212 475 475 TRP TRP A . n 
A 1 213 TYR 213 476 476 TYR TYR A . n 
A 1 214 MET 214 477 477 MET MET A . n 
A 1 215 TRP 215 478 478 TRP TRP A . n 
A 1 216 LEU 216 479 479 LEU LEU A . n 
A 1 217 GLY 217 480 480 GLY GLY A . n 
A 1 218 ALA 218 481 481 ALA ALA A . n 
A 1 219 ARG 219 482 482 ARG ARG A . n 
A 1 220 PHE 220 483 483 PHE PHE A . n 
A 1 221 LEU 221 484 484 LEU LEU A . n 
A 1 222 GLU 222 485 485 GLU GLU A . n 
A 1 223 PHE 223 486 486 PHE PHE A . n 
A 1 224 GLU 224 487 487 GLU GLU A . n 
A 1 225 ALA 225 488 488 ALA ALA A . n 
A 1 226 LEU 226 489 489 LEU LEU A . n 
A 1 227 GLY 227 490 490 GLY GLY A . n 
A 1 228 PHE 228 491 491 PHE PHE A . n 
A 1 229 LEU 229 492 492 LEU LEU A . n 
A 1 230 ASN 230 493 493 ASN ASN A . n 
A 1 231 GLU 231 494 494 GLU GLU A . n 
A 1 232 ASP 232 495 495 ASP ASP A . n 
A 1 233 HIS 233 496 496 HIS HIS A . n 
A 1 234 TRP 234 497 497 TRP TRP A . n 
A 1 235 PHE 235 498 498 PHE PHE A . n 
A 1 236 SER 236 499 499 SER SER A . n 
A 1 237 ARG 237 500 500 ARG ARG A . n 
A 1 238 GLU 238 501 501 GLU GLU A . n 
A 1 239 ASN 239 502 502 ASN ASN A . n 
A 1 240 SER 240 503 503 SER SER A . n 
A 1 241 LEU 241 504 504 LEU LEU A . n 
A 1 242 SER 242 505 505 SER SER A . n 
A 1 243 GLY 243 506 506 GLY GLY A . n 
A 1 244 VAL 244 507 507 VAL VAL A . n 
A 1 245 GLU 245 508 508 GLU GLU A . n 
A 1 246 GLY 246 509 509 GLY GLY A . n 
A 1 247 GLU 247 510 510 GLU GLU A . n 
A 1 248 GLY 248 511 511 GLY GLY A . n 
A 1 249 LEU 249 512 512 LEU LEU A . n 
A 1 250 HIS 250 513 513 HIS HIS A . n 
A 1 251 LYS 251 514 514 LYS LYS A . n 
A 1 252 LEU 252 515 515 LEU LEU A . n 
A 1 253 GLY 253 516 516 GLY GLY A . n 
A 1 254 TYR 254 517 517 TYR TYR A . n 
A 1 255 ILE 255 518 518 ILE ILE A . n 
A 1 256 LEU 256 519 519 LEU LEU A . n 
A 1 257 ARG 257 520 520 ARG ARG A . n 
A 1 258 ASP 258 521 521 ASP ASP A . n 
A 1 259 VAL 259 522 522 VAL VAL A . n 
A 1 260 SER 260 523 523 SER SER A . n 
A 1 261 LYS 261 524 524 LYS LYS A . n 
A 1 262 LYS 262 525 525 LYS LYS A . n 
A 1 263 GLU 263 526 526 GLU GLU A . n 
A 1 264 GLY 264 527 527 GLY GLY A . n 
A 1 265 GLY 265 528 528 GLY GLY A . n 
A 1 266 ALA 266 529 529 ALA ALA A . n 
A 1 267 MET 267 530 530 MET MET A . n 
A 1 268 TYR 268 531 531 TYR TYR A . n 
A 1 269 ALA 269 532 532 ALA ALA A . n 
A 1 270 ASP 270 533 533 ASP ASP A . n 
A 1 271 ASP 271 534 534 ASP ASP A . n 
A 1 272 THR 272 535 535 THR THR A . n 
A 1 273 ALA 273 536 536 ALA ALA A . n 
A 1 274 GLY 274 537 537 GLY GLY A . n 
A 1 275 TRP 275 538 538 TRP TRP A . n 
A 1 276 ASP 276 539 539 ASP ASP A . n 
A 1 277 THR 277 540 540 THR THR A . n 
A 1 278 ARG 278 541 541 ARG ARG A . n 
A 1 279 ILE 279 542 542 ILE ILE A . n 
A 1 280 THR 280 543 543 THR THR A . n 
A 1 281 LEU 281 544 544 LEU LEU A . n 
A 1 282 GLU 282 545 545 GLU GLU A . n 
A 1 283 ASP 283 546 546 ASP ASP A . n 
A 1 284 LEU 284 547 547 LEU LEU A . n 
A 1 285 LYS 285 548 548 LYS LYS A . n 
A 1 286 ASN 286 549 549 ASN ASN A . n 
A 1 287 GLU 287 550 550 GLU GLU A . n 
A 1 288 GLU 288 551 551 GLU GLU A . n 
A 1 289 MET 289 552 552 MET MET A . n 
A 1 290 VAL 290 553 553 VAL VAL A . n 
A 1 291 THR 291 554 554 THR THR A . n 
A 1 292 ASN 292 555 555 ASN ASN A . n 
A 1 293 HIS 293 556 556 HIS HIS A . n 
A 1 294 MET 294 557 557 MET MET A . n 
A 1 295 GLU 295 558 558 GLU GLU A . n 
A 1 296 GLY 296 559 559 GLY GLY A . n 
A 1 297 GLU 297 560 560 GLU GLU A . n 
A 1 298 HIS 298 561 561 HIS HIS A . n 
A 1 299 LYS 299 562 562 LYS LYS A . n 
A 1 300 LYS 300 563 563 LYS LYS A . n 
A 1 301 LEU 301 564 564 LEU LEU A . n 
A 1 302 ALA 302 565 565 ALA ALA A . n 
A 1 303 GLU 303 566 566 GLU GLU A . n 
A 1 304 ALA 304 567 567 ALA ALA A . n 
A 1 305 ILE 305 568 568 ILE ILE A . n 
A 1 306 PHE 306 569 569 PHE PHE A . n 
A 1 307 LYS 307 570 570 LYS LYS A . n 
A 1 308 LEU 308 571 571 LEU LEU A . n 
A 1 309 THR 309 572 572 THR THR A . n 
A 1 310 TYR 310 573 573 TYR TYR A . n 
A 1 311 GLN 311 574 574 GLN GLN A . n 
A 1 312 ASN 312 575 575 ASN ASN A . n 
A 1 313 LYS 313 576 576 LYS LYS A . n 
A 1 314 VAL 314 577 577 VAL VAL A . n 
A 1 315 VAL 315 578 578 VAL VAL A . n 
A 1 316 ARG 316 579 579 ARG ARG A . n 
A 1 317 VAL 317 580 580 VAL VAL A . n 
A 1 318 GLN 318 581 581 GLN GLN A . n 
A 1 319 ARG 319 582 582 ARG ARG A . n 
A 1 320 PRO 320 583 583 PRO PRO A . n 
A 1 321 THR 321 584 584 THR THR A . n 
A 1 322 PRO 322 585 ?   ?   ?   A . n 
A 1 323 ARG 323 586 ?   ?   ?   A . n 
A 1 324 GLY 324 587 ?   ?   ?   A . n 
A 1 325 THR 325 588 588 THR THR A . n 
A 1 326 VAL 326 589 589 VAL VAL A . n 
A 1 327 MET 327 590 590 MET MET A . n 
A 1 328 ASP 328 591 591 ASP ASP A . n 
A 1 329 ILE 329 592 592 ILE ILE A . n 
A 1 330 ILE 330 593 593 ILE ILE A . n 
A 1 331 SER 331 594 594 SER SER A . n 
A 1 332 ARG 332 595 595 ARG ARG A . n 
A 1 333 ARG 333 596 596 ARG ARG A . n 
A 1 334 ASP 334 597 597 ASP ASP A . n 
A 1 335 GLN 335 598 598 GLN GLN A . n 
A 1 336 ARG 336 599 599 ARG ARG A . n 
A 1 337 GLY 337 600 600 GLY GLY A . n 
A 1 338 SER 338 601 601 SER SER A . n 
A 1 339 GLY 339 602 602 GLY GLY A . n 
A 1 340 GLN 340 603 603 GLN GLN A . n 
A 1 341 VAL 341 604 604 VAL VAL A . n 
A 1 342 VAL 342 605 605 VAL VAL A . n 
A 1 343 THR 343 606 606 THR THR A . n 
A 1 344 TYR 344 607 607 TYR TYR A . n 
A 1 345 GLY 345 608 608 GLY GLY A . n 
A 1 346 LEU 346 609 609 LEU LEU A . n 
A 1 347 ASN 347 610 610 ASN ASN A . n 
A 1 348 THR 348 611 611 THR THR A . n 
A 1 349 PHE 349 612 612 PHE PHE A . n 
A 1 350 THR 350 613 613 THR THR A . n 
A 1 351 ASN 351 614 614 ASN ASN A . n 
A 1 352 MET 352 615 615 MET MET A . n 
A 1 353 GLU 353 616 616 GLU GLU A . n 
A 1 354 ALA 354 617 617 ALA ALA A . n 
A 1 355 GLN 355 618 618 GLN GLN A . n 
A 1 356 LEU 356 619 619 LEU LEU A . n 
A 1 357 ILE 357 620 620 ILE ILE A . n 
A 1 358 ARG 358 621 621 ARG ARG A . n 
A 1 359 GLN 359 622 622 GLN GLN A . n 
A 1 360 MET 360 623 623 MET MET A . n 
A 1 361 GLU 361 624 624 GLU GLU A . n 
A 1 362 GLY 362 625 625 GLY GLY A . n 
A 1 363 GLU 363 626 626 GLU GLU A . n 
A 1 364 GLY 364 627 627 GLY GLY A . n 
A 1 365 VAL 365 628 628 VAL VAL A . n 
A 1 366 PHE 366 629 629 PHE PHE A . n 
A 1 367 LYS 367 630 630 LYS LYS A . n 
A 1 368 SER 368 631 631 SER SER A . n 
A 1 369 ILE 369 632 632 ILE ILE A . n 
A 1 370 GLN 370 633 633 GLN GLN A . n 
A 1 371 HIS 371 634 634 HIS HIS A . n 
A 1 372 LEU 372 635 635 LEU LEU A . n 
A 1 373 THR 373 636 636 THR THR A . n 
A 1 374 VAL 374 637 637 VAL VAL A . n 
A 1 375 THR 375 638 638 THR THR A . n 
A 1 376 GLU 376 639 639 GLU GLU A . n 
A 1 377 GLU 377 640 640 GLU GLU A . n 
A 1 378 ILE 378 641 641 ILE ILE A . n 
A 1 379 ALA 379 642 642 ALA ALA A . n 
A 1 380 VAL 380 643 643 VAL VAL A . n 
A 1 381 LYS 381 644 644 LYS LYS A . n 
A 1 382 ASN 382 645 645 ASN ASN A . n 
A 1 383 TRP 383 646 646 TRP TRP A . n 
A 1 384 LEU 384 647 647 LEU LEU A . n 
A 1 385 VAL 385 648 648 VAL VAL A . n 
A 1 386 ARG 386 649 649 ARG ARG A . n 
A 1 387 VAL 387 650 650 VAL VAL A . n 
A 1 388 GLY 388 651 651 GLY GLY A . n 
A 1 389 ARG 389 652 652 ARG ARG A . n 
A 1 390 GLU 390 653 653 GLU GLU A . n 
A 1 391 ARG 391 654 654 ARG ARG A . n 
A 1 392 LEU 392 655 655 LEU LEU A . n 
A 1 393 SER 393 656 656 SER SER A . n 
A 1 394 ARG 394 657 657 ARG ARG A . n 
A 1 395 MET 395 658 658 MET MET A . n 
A 1 396 ALA 396 659 659 ALA ALA A . n 
A 1 397 ILE 397 660 660 ILE ILE A . n 
A 1 398 SER 398 661 661 SER SER A . n 
A 1 399 GLY 399 662 662 GLY GLY A . n 
A 1 400 ASP 400 663 663 ASP ASP A . n 
A 1 401 ASP 401 664 664 ASP ASP A . n 
A 1 402 CYS 402 665 665 CYS CYS A . n 
A 1 403 VAL 403 666 666 VAL VAL A . n 
A 1 404 VAL 404 667 667 VAL VAL A . n 
A 1 405 LYS 405 668 668 LYS LYS A . n 
A 1 406 PRO 406 669 669 PRO PRO A . n 
A 1 407 LEU 407 670 670 LEU LEU A . n 
A 1 408 ASP 408 671 671 ASP ASP A . n 
A 1 409 ASP 409 672 672 ASP ASP A . n 
A 1 410 ARG 410 673 673 ARG ARG A . n 
A 1 411 PHE 411 674 674 PHE PHE A . n 
A 1 412 ALA 412 675 675 ALA ALA A . n 
A 1 413 SER 413 676 676 SER SER A . n 
A 1 414 ALA 414 677 677 ALA ALA A . n 
A 1 415 LEU 415 678 678 LEU LEU A . n 
A 1 416 THR 416 679 679 THR THR A . n 
A 1 417 ALA 417 680 680 ALA ALA A . n 
A 1 418 LEU 418 681 681 LEU LEU A . n 
A 1 419 ASN 419 682 682 ASN ASN A . n 
A 1 420 ASP 420 683 683 ASP ASP A . n 
A 1 421 MET 421 684 684 MET MET A . n 
A 1 422 GLY 422 685 685 GLY GLY A . n 
A 1 423 LYS 423 686 686 LYS LYS A . n 
A 1 424 VAL 424 687 687 VAL VAL A . n 
A 1 425 ARG 425 688 688 ARG ARG A . n 
A 1 426 LYS 426 689 689 LYS LYS A . n 
A 1 427 ASP 427 690 690 ASP ASP A . n 
A 1 428 ILE 428 691 691 ILE ILE A . n 
A 1 429 GLN 429 692 692 GLN GLN A . n 
A 1 430 GLN 430 693 693 GLN GLN A . n 
A 1 431 TRP 431 694 694 TRP TRP A . n 
A 1 432 GLU 432 695 695 GLU GLU A . n 
A 1 433 PRO 433 696 696 PRO PRO A . n 
A 1 434 SER 434 697 697 SER SER A . n 
A 1 435 ARG 435 698 698 ARG ARG A . n 
A 1 436 GLY 436 699 699 GLY GLY A . n 
A 1 437 TRP 437 700 700 TRP TRP A . n 
A 1 438 ASN 438 701 701 ASN ASN A . n 
A 1 439 ASP 439 702 702 ASP ASP A . n 
A 1 440 TRP 440 703 703 TRP TRP A . n 
A 1 441 THR 441 704 704 THR THR A . n 
A 1 442 GLN 442 705 705 GLN GLN A . n 
A 1 443 VAL 443 706 706 VAL VAL A . n 
A 1 444 PRO 444 707 707 PRO PRO A . n 
A 1 445 PHE 445 708 708 PHE PHE A . n 
A 1 446 CYS 446 709 709 CYS CYS A . n 
A 1 447 SER 447 710 710 SER SER A . n 
A 1 448 HIS 448 711 711 HIS HIS A . n 
A 1 449 HIS 449 712 712 HIS HIS A . n 
A 1 450 PHE 450 713 713 PHE PHE A . n 
A 1 451 HIS 451 714 714 HIS HIS A . n 
A 1 452 GLU 452 715 715 GLU GLU A . n 
A 1 453 LEU 453 716 716 LEU LEU A . n 
A 1 454 ILE 454 717 717 ILE ILE A . n 
A 1 455 MET 455 718 718 MET MET A . n 
A 1 456 LYS 456 719 719 LYS LYS A . n 
A 1 457 ASP 457 720 720 ASP ASP A . n 
A 1 458 GLY 458 721 721 GLY GLY A . n 
A 1 459 ARG 459 722 722 ARG ARG A . n 
A 1 460 VAL 460 723 723 VAL VAL A . n 
A 1 461 LEU 461 724 724 LEU LEU A . n 
A 1 462 VAL 462 725 725 VAL VAL A . n 
A 1 463 VAL 463 726 726 VAL VAL A . n 
A 1 464 PRO 464 727 727 PRO PRO A . n 
A 1 465 CYS 465 728 728 CYS CYS A . n 
A 1 466 ARG 466 729 729 ARG ARG A . n 
A 1 467 ASN 467 730 730 ASN ASN A . n 
A 1 468 GLN 468 731 731 GLN GLN A . n 
A 1 469 ASP 469 732 732 ASP ASP A . n 
A 1 470 GLU 470 733 733 GLU GLU A . n 
A 1 471 LEU 471 734 734 LEU LEU A . n 
A 1 472 ILE 472 735 735 ILE ILE A . n 
A 1 473 GLY 473 736 736 GLY GLY A . n 
A 1 474 ARG 474 737 737 ARG ARG A . n 
A 1 475 ALA 475 738 738 ALA ALA A . n 
A 1 476 ARG 476 739 739 ARG ARG A . n 
A 1 477 ILE 477 740 740 ILE ILE A . n 
A 1 478 SER 478 741 741 SER SER A . n 
A 1 479 GLN 479 742 742 GLN GLN A . n 
A 1 480 GLY 480 743 743 GLY GLY A . n 
A 1 481 ALA 481 744 744 ALA ALA A . n 
A 1 482 GLY 482 745 745 GLY GLY A . n 
A 1 483 TRP 483 746 746 TRP TRP A . n 
A 1 484 SER 484 747 747 SER SER A . n 
A 1 485 LEU 485 748 748 LEU LEU A . n 
A 1 486 ARG 486 749 749 ARG ARG A . n 
A 1 487 GLU 487 750 750 GLU GLU A . n 
A 1 488 THR 488 751 751 THR THR A . n 
A 1 489 ALA 489 752 752 ALA ALA A . n 
A 1 490 CYS 490 753 753 CYS CYS A . n 
A 1 491 LEU 491 754 754 LEU LEU A . n 
A 1 492 GLY 492 755 755 GLY GLY A . n 
A 1 493 LYS 493 756 756 LYS LYS A . n 
A 1 494 SER 494 757 757 SER SER A . n 
A 1 495 TYR 495 758 758 TYR TYR A . n 
A 1 496 ALA 496 759 759 ALA ALA A . n 
A 1 497 GLN 497 760 760 GLN GLN A . n 
A 1 498 MET 498 761 761 MET MET A . n 
A 1 499 TRP 499 762 762 TRP TRP A . n 
A 1 500 SER 500 763 763 SER SER A . n 
A 1 501 LEU 501 764 764 LEU LEU A . n 
A 1 502 MET 502 765 765 MET MET A . n 
A 1 503 TYR 503 766 766 TYR TYR A . n 
A 1 504 PHE 504 767 767 PHE PHE A . n 
A 1 505 HIS 505 768 768 HIS HIS A . n 
A 1 506 ARG 506 769 769 ARG ARG A . n 
A 1 507 ARG 507 770 770 ARG ARG A . n 
A 1 508 ASP 508 771 771 ASP ASP A . n 
A 1 509 LEU 509 772 772 LEU LEU A . n 
A 1 510 ARG 510 773 773 ARG ARG A . n 
A 1 511 LEU 511 774 774 LEU LEU A . n 
A 1 512 ALA 512 775 775 ALA ALA A . n 
A 1 513 ALA 513 776 776 ALA ALA A . n 
A 1 514 ASN 514 777 777 ASN ASN A . n 
A 1 515 ALA 515 778 778 ALA ALA A . n 
A 1 516 ILE 516 779 779 ILE ILE A . n 
A 1 517 CYS 517 780 780 CYS CYS A . n 
A 1 518 SER 518 781 781 SER SER A . n 
A 1 519 ALA 519 782 782 ALA ALA A . n 
A 1 520 VAL 520 783 783 VAL VAL A . n 
A 1 521 PRO 521 784 784 PRO PRO A . n 
A 1 522 SER 522 785 785 SER SER A . n 
A 1 523 HIS 523 786 786 HIS HIS A . n 
A 1 524 TRP 524 787 787 TRP TRP A . n 
A 1 525 VAL 525 788 788 VAL VAL A . n 
A 1 526 PRO 526 789 789 PRO PRO A . n 
A 1 527 THR 527 790 790 THR THR A . n 
A 1 528 SER 528 791 791 SER SER A . n 
A 1 529 ARG 529 792 792 ARG ARG A . n 
A 1 530 THR 530 793 793 THR THR A . n 
A 1 531 THR 531 794 ?   ?   ?   A . n 
A 1 532 TRP 532 795 ?   ?   ?   A . n 
A 1 533 SER 533 796 ?   ?   ?   A . n 
A 1 534 ILE 534 797 ?   ?   ?   A . n 
A 1 535 HIS 535 798 ?   ?   ?   A . n 
A 1 536 ALA 536 799 799 ALA ALA A . n 
A 1 537 THR 537 800 800 THR THR A . n 
A 1 538 HIS 538 801 801 HIS HIS A . n 
A 1 539 GLU 539 802 802 GLU GLU A . n 
A 1 540 TRP 540 803 803 TRP TRP A . n 
A 1 541 MET 541 804 804 MET MET A . n 
A 1 542 THR 542 805 805 THR THR A . n 
A 1 543 THR 543 806 806 THR THR A . n 
A 1 544 GLU 544 807 807 GLU GLU A . n 
A 1 545 ASP 545 808 808 ASP ASP A . n 
A 1 546 MET 546 809 809 MET MET A . n 
A 1 547 LEU 547 810 810 LEU LEU A . n 
A 1 548 THR 548 811 811 THR THR A . n 
A 1 549 VAL 549 812 812 VAL VAL A . n 
A 1 550 TRP 550 813 813 TRP TRP A . n 
A 1 551 ASN 551 814 814 ASN ASN A . n 
A 1 552 ARG 552 815 815 ARG ARG A . n 
A 1 553 VAL 553 816 816 VAL VAL A . n 
A 1 554 TRP 554 817 817 TRP TRP A . n 
A 1 555 ILE 555 818 818 ILE ILE A . n 
A 1 556 GLN 556 819 819 GLN GLN A . n 
A 1 557 GLU 557 820 820 GLU GLU A . n 
A 1 558 ASN 558 821 821 ASN ASN A . n 
A 1 559 PRO 559 822 822 PRO PRO A . n 
A 1 560 TRP 560 823 823 TRP TRP A . n 
A 1 561 MET 561 824 824 MET MET A . n 
A 1 562 GLU 562 825 825 GLU GLU A . n 
A 1 563 ASP 563 826 826 ASP ASP A . n 
A 1 564 LYS 564 827 827 LYS LYS A . n 
A 1 565 THR 565 828 828 THR THR A . n 
A 1 566 PRO 566 829 829 PRO PRO A . n 
A 1 567 VAL 567 830 830 VAL VAL A . n 
A 1 568 GLU 568 831 831 GLU GLU A . n 
A 1 569 SER 569 832 832 SER SER A . n 
A 1 570 TRP 570 833 833 TRP TRP A . n 
A 1 571 GLU 571 834 834 GLU GLU A . n 
A 1 572 GLU 572 835 835 GLU GLU A . n 
A 1 573 ILE 573 836 836 ILE ILE A . n 
A 1 574 PRO 574 837 837 PRO PRO A . n 
A 1 575 TYR 575 838 838 TYR TYR A . n 
A 1 576 LEU 576 839 839 LEU LEU A . n 
A 1 577 GLY 577 840 840 GLY GLY A . n 
A 1 578 LYS 578 841 841 LYS LYS A . n 
A 1 579 ARG 579 842 842 ARG ARG A . n 
A 1 580 GLU 580 843 843 GLU GLU A . n 
A 1 581 ASP 581 844 844 ASP ASP A . n 
A 1 582 GLN 582 845 845 GLN GLN A . n 
A 1 583 TRP 583 846 846 TRP TRP A . n 
A 1 584 CYS 584 847 847 CYS CYS A . n 
A 1 585 GLY 585 848 848 GLY GLY A . n 
A 1 586 SER 586 849 849 SER SER A . n 
A 1 587 LEU 587 850 850 LEU LEU A . n 
A 1 588 ILE 588 851 851 ILE ILE A . n 
A 1 589 GLY 589 852 852 GLY GLY A . n 
A 1 590 LEU 590 853 853 LEU LEU A . n 
A 1 591 THR 591 854 854 THR THR A . n 
A 1 592 SER 592 855 855 SER SER A . n 
A 1 593 ARG 593 856 856 ARG ARG A . n 
A 1 594 ALA 594 857 857 ALA ALA A . n 
A 1 595 THR 595 858 858 THR THR A . n 
A 1 596 TRP 596 859 859 TRP TRP A . n 
A 1 597 ALA 597 860 860 ALA ALA A . n 
A 1 598 LYS 598 861 861 LYS LYS A . n 
A 1 599 ASN 599 862 862 ASN ASN A . n 
A 1 600 ILE 600 863 863 ILE ILE A . n 
A 1 601 GLN 601 864 864 GLN GLN A . n 
A 1 602 THR 602 865 865 THR THR A . n 
A 1 603 ALA 603 866 866 ALA ALA A . n 
A 1 604 ILE 604 867 867 ILE ILE A . n 
A 1 605 ASN 605 868 868 ASN ASN A . n 
A 1 606 GLN 606 869 869 GLN GLN A . n 
A 1 607 VAL 607 870 870 VAL VAL A . n 
A 1 608 ARG 608 871 871 ARG ARG A . n 
A 1 609 SER 609 872 872 SER SER A . n 
A 1 610 LEU 610 873 873 LEU LEU A . n 
A 1 611 ILE 611 874 874 ILE ILE A . n 
A 1 612 GLY 612 875 875 GLY GLY A . n 
A 1 613 ASN 613 876 876 ASN ASN A . n 
A 1 614 GLU 614 877 877 GLU GLU A . n 
A 1 615 GLU 615 878 878 GLU GLU A . n 
A 1 616 TYR 616 879 879 TYR TYR A . n 
A 1 617 THR 617 880 880 THR THR A . n 
A 1 618 ASP 618 881 881 ASP ASP A . n 
A 1 619 TYR 619 882 882 TYR TYR A . n 
A 1 620 MET 620 883 883 MET MET A . n 
A 1 621 PRO 621 884 884 PRO PRO A . n 
A 1 622 SER 622 885 885 SER SER A . n 
A 1 623 MET 623 886 886 MET MET A . n 
A 1 624 LYS 624 887 887 LYS LYS A . n 
A 1 625 ARG 625 888 888 ARG ARG A . n 
A 1 626 PHE 626 889 889 PHE PHE A . n 
A 1 627 ARG 627 890 890 ARG ARG A . n 
A 1 628 ARG 628 891 891 ARG ARG A . n 
A 1 629 GLU 629 892 ?   ?   ?   A . n 
A 1 630 GLU 630 893 ?   ?   ?   A . n 
A 1 631 GLU 631 894 ?   ?   ?   A . n 
A 1 632 GLU 632 895 ?   ?   ?   A . n 
A 1 633 ALA 633 896 ?   ?   ?   A . n 
A 1 634 GLY 634 897 ?   ?   ?   A . n 
A 1 635 VAL 635 898 ?   ?   ?   A . n 
A 1 636 LEU 636 899 ?   ?   ?   A . n 
A 1 637 TRP 637 900 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        X0S 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   X0S 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 ZN  1   1001 1001 ZN  ZN  A . 
C 2 ZN  1   1002 1002 ZN  ZN  A . 
D 3 MES 1   1003 1004 MES MES A . 
E 4 DMS 1   1004 1530 DMS DMS A . 
F 4 DMS 1   1005 1602 DMS DMS A . 
G 5 PEG 1   1006 1603 PEG PEG A . 
H 6 PO4 1   1007 1604 PO4 PO4 A . 
I 6 PO4 1   1008 1606 PO4 PO4 A . 
J 5 PEG 1   1009 1607 PEG PEG A . 
K 7 X0S 1   1010 1707 X0S LIG A . 
L 7 X0S 1   1011 1801 X0S LIG A . 
M 8 CL  1   1012 1    CL  CL  A . 
N 9 HOH 1   1101 97   HOH HOH A . 
N 9 HOH 2   1102 118  HOH HOH A . 
N 9 HOH 3   1103 132  HOH HOH A . 
N 9 HOH 4   1104 215  HOH HOH A . 
N 9 HOH 5   1105 169  HOH HOH A . 
N 9 HOH 6   1106 188  HOH HOH A . 
N 9 HOH 7   1107 93   HOH HOH A . 
N 9 HOH 8   1108 211  HOH HOH A . 
N 9 HOH 9   1109 172  HOH HOH A . 
N 9 HOH 10  1110 192  HOH HOH A . 
N 9 HOH 11  1111 330  HOH HOH A . 
N 9 HOH 12  1112 335  HOH HOH A . 
N 9 HOH 13  1113 203  HOH HOH A . 
N 9 HOH 14  1114 181  HOH HOH A . 
N 9 HOH 15  1115 10   HOH HOH A . 
N 9 HOH 16  1116 129  HOH HOH A . 
N 9 HOH 17  1117 72   HOH HOH A . 
N 9 HOH 18  1118 160  HOH HOH A . 
N 9 HOH 19  1119 225  HOH HOH A . 
N 9 HOH 20  1120 183  HOH HOH A . 
N 9 HOH 21  1121 237  HOH HOH A . 
N 9 HOH 22  1122 150  HOH HOH A . 
N 9 HOH 23  1123 231  HOH HOH A . 
N 9 HOH 24  1124 212  HOH HOH A . 
N 9 HOH 25  1125 2    HOH HOH A . 
N 9 HOH 26  1126 138  HOH HOH A . 
N 9 HOH 27  1127 145  HOH HOH A . 
N 9 HOH 28  1128 394  HOH HOH A . 
N 9 HOH 29  1129 189  HOH HOH A . 
N 9 HOH 30  1130 249  HOH HOH A . 
N 9 HOH 31  1131 162  HOH HOH A . 
N 9 HOH 32  1132 3    HOH HOH A . 
N 9 HOH 33  1133 216  HOH HOH A . 
N 9 HOH 34  1134 133  HOH HOH A . 
N 9 HOH 35  1135 121  HOH HOH A . 
N 9 HOH 36  1136 147  HOH HOH A . 
N 9 HOH 37  1137 208  HOH HOH A . 
N 9 HOH 38  1138 146  HOH HOH A . 
N 9 HOH 39  1139 185  HOH HOH A . 
N 9 HOH 40  1140 270  HOH HOH A . 
N 9 HOH 41  1141 152  HOH HOH A . 
N 9 HOH 42  1142 79   HOH HOH A . 
N 9 HOH 43  1143 299  HOH HOH A . 
N 9 HOH 44  1144 50   HOH HOH A . 
N 9 HOH 45  1145 257  HOH HOH A . 
N 9 HOH 46  1146 45   HOH HOH A . 
N 9 HOH 47  1147 255  HOH HOH A . 
N 9 HOH 48  1148 243  HOH HOH A . 
N 9 HOH 49  1149 184  HOH HOH A . 
N 9 HOH 50  1150 120  HOH HOH A . 
N 9 HOH 51  1151 58   HOH HOH A . 
N 9 HOH 52  1152 226  HOH HOH A . 
N 9 HOH 53  1153 22   HOH HOH A . 
N 9 HOH 54  1154 191  HOH HOH A . 
N 9 HOH 55  1155 252  HOH HOH A . 
N 9 HOH 56  1156 156  HOH HOH A . 
N 9 HOH 57  1157 31   HOH HOH A . 
N 9 HOH 58  1158 177  HOH HOH A . 
N 9 HOH 59  1159 151  HOH HOH A . 
N 9 HOH 60  1160 154  HOH HOH A . 
N 9 HOH 61  1161 157  HOH HOH A . 
N 9 HOH 62  1162 174  HOH HOH A . 
N 9 HOH 63  1163 320  HOH HOH A . 
N 9 HOH 64  1164 233  HOH HOH A . 
N 9 HOH 65  1165 297  HOH HOH A . 
N 9 HOH 66  1166 193  HOH HOH A . 
N 9 HOH 67  1167 240  HOH HOH A . 
N 9 HOH 68  1168 128  HOH HOH A . 
N 9 HOH 69  1169 69   HOH HOH A . 
N 9 HOH 70  1170 142  HOH HOH A . 
N 9 HOH 71  1171 134  HOH HOH A . 
N 9 HOH 72  1172 126  HOH HOH A . 
N 9 HOH 73  1173 179  HOH HOH A . 
N 9 HOH 74  1174 219  HOH HOH A . 
N 9 HOH 75  1175 196  HOH HOH A . 
N 9 HOH 76  1176 122  HOH HOH A . 
N 9 HOH 77  1177 153  HOH HOH A . 
N 9 HOH 78  1178 149  HOH HOH A . 
N 9 HOH 79  1179 155  HOH HOH A . 
N 9 HOH 80  1180 137  HOH HOH A . 
N 9 HOH 81  1181 296  HOH HOH A . 
N 9 HOH 82  1182 279  HOH HOH A . 
N 9 HOH 83  1183 173  HOH HOH A . 
N 9 HOH 84  1184 144  HOH HOH A . 
N 9 HOH 85  1185 242  HOH HOH A . 
N 9 HOH 86  1186 125  HOH HOH A . 
N 9 HOH 87  1187 294  HOH HOH A . 
N 9 HOH 88  1188 23   HOH HOH A . 
N 9 HOH 89  1189 5    HOH HOH A . 
N 9 HOH 90  1190 200  HOH HOH A . 
N 9 HOH 91  1191 341  HOH HOH A . 
N 9 HOH 92  1192 81   HOH HOH A . 
N 9 HOH 93  1193 194  HOH HOH A . 
N 9 HOH 94  1194 104  HOH HOH A . 
N 9 HOH 95  1195 229  HOH HOH A . 
N 9 HOH 96  1196 329  HOH HOH A . 
N 9 HOH 97  1197 224  HOH HOH A . 
N 9 HOH 98  1198 55   HOH HOH A . 
N 9 HOH 99  1199 139  HOH HOH A . 
N 9 HOH 100 1200 182  HOH HOH A . 
N 9 HOH 101 1201 74   HOH HOH A . 
N 9 HOH 102 1202 209  HOH HOH A . 
N 9 HOH 103 1203 119  HOH HOH A . 
N 9 HOH 104 1204 17   HOH HOH A . 
N 9 HOH 105 1205 276  HOH HOH A . 
N 9 HOH 106 1206 391  HOH HOH A . 
N 9 HOH 107 1207 284  HOH HOH A . 
N 9 HOH 108 1208 389  HOH HOH A . 
N 9 HOH 109 1209 41   HOH HOH A . 
N 9 HOH 110 1210 246  HOH HOH A . 
N 9 HOH 111 1211 259  HOH HOH A . 
N 9 HOH 112 1212 244  HOH HOH A . 
N 9 HOH 113 1213 14   HOH HOH A . 
N 9 HOH 114 1214 117  HOH HOH A . 
N 9 HOH 115 1215 167  HOH HOH A . 
N 9 HOH 116 1216 287  HOH HOH A . 
N 9 HOH 117 1217 301  HOH HOH A . 
N 9 HOH 118 1218 7    HOH HOH A . 
N 9 HOH 119 1219 135  HOH HOH A . 
N 9 HOH 120 1220 210  HOH HOH A . 
N 9 HOH 121 1221 223  HOH HOH A . 
N 9 HOH 122 1222 251  HOH HOH A . 
N 9 HOH 123 1223 245  HOH HOH A . 
N 9 HOH 124 1224 171  HOH HOH A . 
N 9 HOH 125 1225 123  HOH HOH A . 
N 9 HOH 126 1226 241  HOH HOH A . 
N 9 HOH 127 1227 272  HOH HOH A . 
N 9 HOH 128 1228 127  HOH HOH A . 
N 9 HOH 129 1229 378  HOH HOH A . 
N 9 HOH 130 1230 180  HOH HOH A . 
N 9 HOH 131 1231 235  HOH HOH A . 
N 9 HOH 132 1232 198  HOH HOH A . 
N 9 HOH 133 1233 84   HOH HOH A . 
N 9 HOH 134 1234 28   HOH HOH A . 
N 9 HOH 135 1235 395  HOH HOH A . 
N 9 HOH 136 1236 158  HOH HOH A . 
N 9 HOH 137 1237 4    HOH HOH A . 
N 9 HOH 138 1238 207  HOH HOH A . 
N 9 HOH 139 1239 261  HOH HOH A . 
N 9 HOH 140 1240 273  HOH HOH A . 
N 9 HOH 141 1241 321  HOH HOH A . 
N 9 HOH 142 1242 130  HOH HOH A . 
N 9 HOH 143 1243 163  HOH HOH A . 
N 9 HOH 144 1244 290  HOH HOH A . 
N 9 HOH 145 1245 388  HOH HOH A . 
N 9 HOH 146 1246 262  HOH HOH A . 
N 9 HOH 147 1247 214  HOH HOH A . 
N 9 HOH 148 1248 217  HOH HOH A . 
N 9 HOH 149 1249 307  HOH HOH A . 
N 9 HOH 150 1250 248  HOH HOH A . 
N 9 HOH 151 1251 30   HOH HOH A . 
N 9 HOH 152 1252 190  HOH HOH A . 
N 9 HOH 153 1253 32   HOH HOH A . 
N 9 HOH 154 1254 178  HOH HOH A . 
N 9 HOH 155 1255 131  HOH HOH A . 
N 9 HOH 156 1256 334  HOH HOH A . 
N 9 HOH 157 1257 340  HOH HOH A . 
N 9 HOH 158 1258 227  HOH HOH A . 
N 9 HOH 159 1259 199  HOH HOH A . 
N 9 HOH 160 1260 204  HOH HOH A . 
N 9 HOH 161 1261 250  HOH HOH A . 
N 9 HOH 162 1262 278  HOH HOH A . 
N 9 HOH 163 1263 89   HOH HOH A . 
N 9 HOH 164 1264 164  HOH HOH A . 
N 9 HOH 165 1265 295  HOH HOH A . 
N 9 HOH 166 1266 293  HOH HOH A . 
N 9 HOH 167 1267 230  HOH HOH A . 
N 9 HOH 168 1268 263  HOH HOH A . 
N 9 HOH 169 1269 35   HOH HOH A . 
N 9 HOH 170 1270 258  HOH HOH A . 
N 9 HOH 171 1271 206  HOH HOH A . 
N 9 HOH 172 1272 195  HOH HOH A . 
N 9 HOH 173 1273 140  HOH HOH A . 
N 9 HOH 174 1274 59   HOH HOH A . 
N 9 HOH 175 1275 292  HOH HOH A . 
N 9 HOH 176 1276 367  HOH HOH A . 
N 9 HOH 177 1277 317  HOH HOH A . 
N 9 HOH 178 1278 186  HOH HOH A . 
N 9 HOH 179 1279 1    HOH HOH A . 
N 9 HOH 180 1280 39   HOH HOH A . 
N 9 HOH 181 1281 337  HOH HOH A . 
N 9 HOH 182 1282 33   HOH HOH A . 
N 9 HOH 183 1283 274  HOH HOH A . 
N 9 HOH 184 1284 291  HOH HOH A . 
N 9 HOH 185 1285 234  HOH HOH A . 
N 9 HOH 186 1286 57   HOH HOH A . 
N 9 HOH 187 1287 314  HOH HOH A . 
N 9 HOH 188 1288 285  HOH HOH A . 
N 9 HOH 189 1289 304  HOH HOH A . 
N 9 HOH 190 1290 13   HOH HOH A . 
N 9 HOH 191 1291 289  HOH HOH A . 
N 9 HOH 192 1292 60   HOH HOH A . 
N 9 HOH 193 1293 386  HOH HOH A . 
N 9 HOH 194 1294 333  HOH HOH A . 
N 9 HOH 195 1295 170  HOH HOH A . 
N 9 HOH 196 1296 70   HOH HOH A . 
N 9 HOH 197 1297 222  HOH HOH A . 
N 9 HOH 198 1298 256  HOH HOH A . 
N 9 HOH 199 1299 175  HOH HOH A . 
N 9 HOH 200 1300 283  HOH HOH A . 
N 9 HOH 201 1301 275  HOH HOH A . 
N 9 HOH 202 1302 310  HOH HOH A . 
N 9 HOH 203 1303 331  HOH HOH A . 
N 9 HOH 204 1304 106  HOH HOH A . 
N 9 HOH 205 1305 168  HOH HOH A . 
N 9 HOH 206 1306 101  HOH HOH A . 
N 9 HOH 207 1307 48   HOH HOH A . 
N 9 HOH 208 1308 264  HOH HOH A . 
N 9 HOH 209 1309 381  HOH HOH A . 
N 9 HOH 210 1310 18   HOH HOH A . 
N 9 HOH 211 1311 308  HOH HOH A . 
N 9 HOH 212 1312 281  HOH HOH A . 
N 9 HOH 213 1313 265  HOH HOH A . 
N 9 HOH 214 1314 73   HOH HOH A . 
N 9 HOH 215 1315 298  HOH HOH A . 
N 9 HOH 216 1316 303  HOH HOH A . 
N 9 HOH 217 1317 300  HOH HOH A . 
N 9 HOH 218 1318 220  HOH HOH A . 
N 9 HOH 219 1319 202  HOH HOH A . 
N 9 HOH 220 1320 266  HOH HOH A . 
N 9 HOH 221 1321 71   HOH HOH A . 
N 9 HOH 222 1322 277  HOH HOH A . 
N 9 HOH 223 1323 236  HOH HOH A . 
N 9 HOH 224 1324 318  HOH HOH A . 
N 9 HOH 225 1325 165  HOH HOH A . 
N 9 HOH 226 1326 36   HOH HOH A . 
N 9 HOH 227 1327 51   HOH HOH A . 
N 9 HOH 228 1328 6    HOH HOH A . 
N 9 HOH 229 1329 319  HOH HOH A . 
N 9 HOH 230 1330 339  HOH HOH A . 
N 9 HOH 231 1331 25   HOH HOH A . 
N 9 HOH 232 1332 286  HOH HOH A . 
N 9 HOH 233 1333 232  HOH HOH A . 
N 9 HOH 234 1334 322  HOH HOH A . 
N 9 HOH 235 1335 306  HOH HOH A . 
N 9 HOH 236 1336 124  HOH HOH A . 
N 9 HOH 237 1337 305  HOH HOH A . 
N 9 HOH 238 1338 342  HOH HOH A . 
N 9 HOH 239 1339 68   HOH HOH A . 
N 9 HOH 240 1340 260  HOH HOH A . 
N 9 HOH 241 1341 280  HOH HOH A . 
N 9 HOH 242 1342 302  HOH HOH A . 
N 9 HOH 243 1343 392  HOH HOH A . 
N 9 HOH 244 1344 148  HOH HOH A . 
N 9 HOH 245 1345 393  HOH HOH A . 
N 9 HOH 246 1346 338  HOH HOH A . 
N 9 HOH 247 1347 311  HOH HOH A . 
N 9 HOH 248 1348 336  HOH HOH A . 
N 9 HOH 249 1349 78   HOH HOH A . 
N 9 HOH 250 1350 16   HOH HOH A . 
N 9 HOH 251 1351 102  HOH HOH A . 
N 9 HOH 252 1352 228  HOH HOH A . 
N 9 HOH 253 1353 201  HOH HOH A . 
N 9 HOH 254 1354 374  HOH HOH A . 
N 9 HOH 255 1355 362  HOH HOH A . 
N 9 HOH 256 1356 309  HOH HOH A . 
N 9 HOH 257 1357 332  HOH HOH A . 
N 9 HOH 258 1358 349  HOH HOH A . 
N 9 HOH 259 1359 358  HOH HOH A . 
N 9 HOH 260 1360 98   HOH HOH A . 
N 9 HOH 261 1361 351  HOH HOH A . 
N 9 HOH 262 1362 103  HOH HOH A . 
N 9 HOH 263 1363 205  HOH HOH A . 
N 9 HOH 264 1364 46   HOH HOH A . 
N 9 HOH 265 1365 382  HOH HOH A . 
N 9 HOH 266 1366 37   HOH HOH A . 
N 9 HOH 267 1367 247  HOH HOH A . 
N 9 HOH 268 1368 67   HOH HOH A . 
N 9 HOH 269 1369 357  HOH HOH A . 
N 9 HOH 270 1370 384  HOH HOH A . 
N 9 HOH 271 1371 42   HOH HOH A . 
N 9 HOH 272 1372 86   HOH HOH A . 
N 9 HOH 273 1373 85   HOH HOH A . 
N 9 HOH 274 1374 360  HOH HOH A . 
N 9 HOH 275 1375 383  HOH HOH A . 
N 9 HOH 276 1376 92   HOH HOH A . 
N 9 HOH 277 1377 267  HOH HOH A . 
N 9 HOH 278 1378 8    HOH HOH A . 
N 9 HOH 279 1379 364  HOH HOH A . 
N 9 HOH 280 1380 361  HOH HOH A . 
N 9 HOH 281 1381 83   HOH HOH A . 
N 9 HOH 282 1382 368  HOH HOH A . 
N 9 HOH 283 1383 366  HOH HOH A . 
N 9 HOH 284 1384 254  HOH HOH A . 
N 9 HOH 285 1385 371  HOH HOH A . 
N 9 HOH 286 1386 363  HOH HOH A . 
N 9 HOH 287 1387 365  HOH HOH A . 
N 9 HOH 288 1388 369  HOH HOH A . 
N 9 HOH 289 1389 62   HOH HOH A . 
N 9 HOH 290 1390 372  HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 A THR 344 ? CB  ? A THR 81 CB  
2 1 Y 1 A THR 344 ? OG1 ? A THR 81 OG1 
3 1 Y 1 A THR 344 ? CG2 ? A THR 81 CG2 
# 
loop_
_software.classification 
_software.name 
_software.version 
_software.citation_id 
_software.pdbx_ordinal 
_software.date 
_software.type 
_software.location 
_software.language 
refinement       REFMAC  5.8.0267 ? 1 ? ? ? ? 
'data scaling'   Aimless .        ? 2 ? ? ? ? 
phasing          PHASER  .        ? 3 ? ? ? ? 
'data reduction' XDS     .        ? 4 ? ? ? ? 
# 
_cell.entry_id           7I28 
_cell.length_a           82.558 
_cell.length_b           117.169 
_cell.length_c           148.292 
_cell.angle_alpha        90.00 
_cell.angle_beta         90.00 
_cell.angle_gamma        90.00 
_cell.Z_PDB              8 
_cell.pdbx_unique_axis   ? 
# 
_symmetry.entry_id                         7I28 
_symmetry.space_group_name_H-M             'I 2 2 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                23 
# 
_exptl.entry_id          7I28 
_exptl.method            'X-RAY DIFFRACTION' 
_exptl.crystals_number   1 
# 
_exptl_crystal.id                    1 
_exptl_crystal.density_meas          ? 
_exptl_crystal.density_Matthews      2.43 
_exptl_crystal.density_percent_sol   49.31 
_exptl_crystal.description           ? 
_exptl_crystal.preparation           ? 
# 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.pH              6.5 
_exptl_crystal_grow.temp            293.15 
_exptl_crystal_grow.pdbx_details    '350 mM Magnesium chloride, 10% PEG 4000, 100 mM MES, pH 6.5' 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.pdbx_pH_range   ? 
# 
_diffrn.id                               1 
_diffrn.ambient_temp                     100 
_diffrn.crystal_id                       1 
_diffrn.ambient_temp_details             ? 
_diffrn.pdbx_serial_crystal_experiment   ? 
# 
_diffrn_detector.detector               PIXEL 
_diffrn_detector.type                   'DECTRIS EIGER2 XE 9M' 
_diffrn_detector.pdbx_collection_date   2023-08-08 
_diffrn_detector.diffrn_id              1 
_diffrn_detector.details                ? 
# 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.92124 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.diffrn_id                   1 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.type                        'DIAMOND BEAMLINE I04-1' 
_diffrn_source.pdbx_wavelength_list        0.92124 
_diffrn_source.pdbx_synchrotron_site       Diamond 
_diffrn_source.pdbx_synchrotron_beamline   I04-1 
_diffrn_source.pdbx_wavelength             ? 
# 
_reflns.entry_id                     7I28 
_reflns.pdbx_diffrn_id               1 
_reflns.pdbx_ordinal                 1 
_reflns.d_resolution_low             74.17 
_reflns.d_resolution_high            1.63 
_reflns.number_obs                   89670 
_reflns.percent_possible_obs         100.0 
_reflns.pdbx_Rmerge_I_obs            0.131 
_reflns.pdbx_netI_over_sigmaI        9.7 
_reflns.pdbx_redundancy              13.1 
_reflns.pdbx_Rrim_I_all              0.136 
_reflns.pdbx_Rpim_I_all              0.037 
_reflns.pdbx_CC_half                 0.999 
_reflns.pdbx_number_measured_all     1172538 
_reflns.pdbx_chi_squared             0.36 
_reflns.observed_criterion_sigma_I   ? 
_reflns.observed_criterion_sigma_F   ? 
_reflns.number_all                   ? 
_reflns.pdbx_Rsym_value              ? 
_reflns.B_iso_Wilson_estimate        ? 
_reflns.pdbx_CC_star                 ? 
# 
_reflns_shell.pdbx_diffrn_id              1 
_reflns_shell.pdbx_ordinal                1 
_reflns_shell.d_res_high                  1.63 
_reflns_shell.d_res_low                   1.66 
_reflns_shell.number_measured_all         46193 
_reflns_shell.number_unique_obs           4521 
_reflns_shell.Rmerge_I_obs                4.469 
_reflns_shell.pdbx_chi_squared            0.11 
_reflns_shell.pdbx_redundancy             10.2 
_reflns_shell.percent_possible_obs        99.4 
_reflns_shell.pdbx_netI_over_sigmaI_obs   0.2 
_reflns_shell.pdbx_Rrim_I_all             4.705 
_reflns_shell.pdbx_Rpim_I_all             1.459 
_reflns_shell.pdbx_CC_half                0.444 
_reflns_shell.percent_possible_all        ? 
_reflns_shell.pdbx_Rsym_value             ? 
_reflns_shell.meanI_over_sigI_obs         ? 
_reflns_shell.number_measured_obs         ? 
_reflns_shell.number_unique_all           ? 
_reflns_shell.pdbx_CC_star                ? 
# 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.entry_id                                 7I28 
_refine.pdbx_diffrn_id                           1 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     80123 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             74.15 
_refine.ls_d_res_high                            1.63 
_refine.ls_percent_reflns_obs                    94.1 
_refine.ls_R_factor_obs                          0.219 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       0.217 
_refine.ls_R_factor_R_free                       0.250 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 5.100 
_refine.ls_number_reflns_R_free                  4307 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               0.948 
_refine.correlation_coeff_Fo_to_Fc_free          0.944 
_refine.B_iso_mean                               51.06 
_refine.aniso_B[1][1]                            -2.20000 
_refine.aniso_B[2][2]                            0.50000 
_refine.aniso_B[3][3]                            1.70000 
_refine.aniso_B[1][2]                            0.00000 
_refine.aniso_B[1][3]                            0.00000 
_refine.aniso_B[2][3]                            0.00000 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             1.20 
_refine.pdbx_solvent_ion_probe_radii             0.80 
_refine.pdbx_solvent_shrinkage_radii             0.80 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.details                                  
;HYDROGENS HAVE BEEN ADDED IN THE RIDING
 POSITIONS
;
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_overall_ESU_R                       0.273 
_refine.pdbx_overall_ESU_R_Free                  0.176 
_refine.overall_SU_ML                            0.253 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             8.961 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.pdbx_number_atoms_protein        4662 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         71 
_refine_hist.number_atoms_solvent             290 
_refine_hist.number_atoms_total               5023 
_refine_hist.d_res_high                       1.63 
_refine_hist.d_res_low                        74.15 
# 
loop_
_refine_ls_restr.type 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.weight 
_refine_ls_restr.number 
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.pdbx_restraint_function 
r_bond_refined_d             0.006  0.015  ? 18572 'X-RAY DIFFRACTION' ? 
r_bond_other_d               0.001  0.015  ? 11789 'X-RAY DIFFRACTION' ? 
r_angle_refined_deg          1.428  1.642  ? 17393 'X-RAY DIFFRACTION' ? 
r_angle_other_deg            1.227  1.593  ? 27349 'X-RAY DIFFRACTION' ? 
r_dihedral_angle_1_deg       6.449  5.000  ? 1625  'X-RAY DIFFRACTION' ? 
r_dihedral_angle_2_deg       32.335 22.066 ? 731   'X-RAY DIFFRACTION' ? 
r_dihedral_angle_3_deg       16.287 15.000 ? 2352  'X-RAY DIFFRACTION' ? 
r_dihedral_angle_4_deg       17.557 15.000 ? 101   'X-RAY DIFFRACTION' ? 
r_chiral_restr               0.066  0.200  ? 1567  'X-RAY DIFFRACTION' ? 
r_gen_planes_refined         0.007  0.020  ? 15160 'X-RAY DIFFRACTION' ? 
r_gen_planes_other           0.002  0.020  ? 3106  'X-RAY DIFFRACTION' ? 
r_nbd_refined                ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbd_other                  ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbtor_refined              ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbtor_other                ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_xyhbond_nbd_refined        ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_xyhbond_nbd_other          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_metal_ion_refined          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_metal_ion_other            ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_vdw_refined       ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_vdw_other         ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_hbond_refined     ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_hbond_other       ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_metal_ion_refined ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_metal_ion_other   ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_mcbond_it                  2.632  5.017  ? 9171  'X-RAY DIFFRACTION' ? 
r_mcbond_other               2.744  5.139  ? 8441  'X-RAY DIFFRACTION' ? 
r_mcangle_it                 5.095  7.400  ? 7809  'X-RAY DIFFRACTION' ? 
r_mcangle_other              5.095  7.400  ? 7810  'X-RAY DIFFRACTION' ? 
r_scbond_it                  2.806  5.533  ? 9372  'X-RAY DIFFRACTION' ? 
r_scbond_other               2.806  5.533  ? 9372  'X-RAY DIFFRACTION' ? 
r_scangle_it                 ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_scangle_other              5.455  8.079  ? 9555  'X-RAY DIFFRACTION' ? 
r_long_range_B_refined       13.245 55.597 ? 15866 'X-RAY DIFFRACTION' ? 
r_long_range_B_other         13.189 55.626 ? 15550 'X-RAY DIFFRACTION' ? 
r_rigid_bond_restr           ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_sphericity_free            ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_sphericity_bonded          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.d_res_high                       1.63 
_refine_ls_shell.d_res_low                        1.67 
_refine_ls_shell.number_reflns_R_work             3035 
_refine_ls_shell.R_factor_R_work                  0.5170 
_refine_ls_shell.percent_reflns_obs               48.22 
_refine_ls_shell.R_factor_R_free                  0.4720 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.number_reflns_R_free             143 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.number_reflns_obs                ? 
# 
_struct.entry_id                  7I28 
_struct.title                     
;Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 -- Crystal structure of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 in complex with Z45527714 (DNV2_NS5A-x0153)
;
_struct.pdbx_model_details        ? 
_struct.pdbx_CASP_flag            ? 
_struct.pdbx_model_type_details   ? 
# 
_struct_keywords.entry_id        7I28 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
_struct_keywords.text            
;Diamond Light Source, I04-1, READDI, Dengue Virus, crystallographic fragment screening, PanDDA, XChemExplorer, cluster4x, VIRAL PROTEIN
;
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 2 ? 
D N N 3 ? 
E N N 4 ? 
F N N 4 ? 
G N N 5 ? 
H N N 6 ? 
I N N 6 ? 
J N N 5 ? 
K N N 7 ? 
L N N 7 ? 
M N N 8 ? 
N N N 9 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    Q91H74_9FLAV 
_struct_ref.pdbx_db_accession          Q91H74 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;GIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAMTD
TTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAREA
VEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENSLS
GVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRPTP
RGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGDDC
VVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQGAG
WSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPWME
DKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_struct_ref.pdbx_align_begin           2757 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              7I28 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 3 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 637 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q91H74 
_struct_ref_seq.db_align_beg                  2757 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  3391 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       266 
_struct_ref_seq.pdbx_auth_seq_align_end       900 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 7I28 GLY A 1 ? UNP Q91H74 ? ? 'expression tag' 264 1 
1 7I28 PRO A 2 ? UNP Q91H74 ? ? 'expression tag' 265 2 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L,M,N 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASN A 10  ? HIS A 25  ? ASN A 273 HIS A 288 1 ? 16 
HELX_P HELX_P2  AA2 ASN A 59  ? LEU A 65  ? ASN A 322 LEU A 328 1 ? 7  
HELX_P HELX_P3  AA3 THR A 66  ? ILE A 71  ? THR A 329 ILE A 334 5 ? 6  
HELX_P HELX_P4  AA4 ILE A 72  ? MET A 78  ? ILE A 335 MET A 341 1 ? 7  
HELX_P HELX_P5  AA5 LYS A 104 ? LYS A 124 ? LYS A 367 LYS A 387 1 ? 21 
HELX_P HELX_P6  AA6 THR A 132 ? SER A 142 ? THR A 395 SER A 405 1 ? 11 
HELX_P HELX_P7  AA7 SER A 158 ? ASP A 165 ? SER A 421 ASP A 428 1 ? 8  
HELX_P HELX_P8  AA8 ASP A 165 ? GLU A 181 ? ASP A 428 GLU A 444 1 ? 17 
HELX_P HELX_P9  AA9 TRP A 215 ? GLY A 227 ? TRP A 478 GLY A 490 1 ? 13 
HELX_P HELX_P10 AB1 GLY A 227 ? ASP A 232 ? GLY A 490 ASP A 495 1 ? 6  
HELX_P HELX_P11 AB2 SER A 236 ? LEU A 241 ? SER A 499 LEU A 504 1 ? 6  
HELX_P HELX_P12 AB3 GLY A 248 ? LYS A 261 ? GLY A 511 LYS A 524 1 ? 14 
HELX_P HELX_P13 AB4 TRP A 275 ? ILE A 279 ? TRP A 538 ILE A 542 5 ? 5  
HELX_P HELX_P14 AB5 THR A 280 ? MET A 289 ? THR A 543 MET A 552 1 ? 10 
HELX_P HELX_P15 AB6 VAL A 290 ? MET A 294 ? VAL A 553 MET A 557 5 ? 5  
HELX_P HELX_P16 AB7 GLU A 295 ? TYR A 310 ? GLU A 558 TYR A 573 1 ? 16 
HELX_P HELX_P17 AB8 GLY A 339 ? GLU A 363 ? GLY A 602 GLU A 626 1 ? 25 
HELX_P HELX_P18 AB9 THR A 373 ? ARG A 394 ? THR A 636 ARG A 657 1 ? 22 
HELX_P HELX_P19 AC1 ASP A 408 ? ALA A 414 ? ASP A 671 ALA A 677 5 ? 7  
HELX_P HELX_P20 AC2 LEU A 415 ? MET A 421 ? LEU A 678 MET A 684 1 ? 7  
HELX_P HELX_P21 AC3 ASP A 439 ? VAL A 443 ? ASP A 702 VAL A 706 5 ? 5  
HELX_P HELX_P22 AC4 ASN A 467 ? ARG A 476 ? ASN A 730 ARG A 739 1 ? 10 
HELX_P HELX_P23 AC5 SER A 484 ? TYR A 503 ? SER A 747 TYR A 766 1 ? 20 
HELX_P HELX_P24 AC6 ARG A 506 ? VAL A 520 ? ARG A 769 VAL A 783 1 ? 15 
HELX_P HELX_P25 AC7 ASP A 545 ? ILE A 555 ? ASP A 808 ILE A 818 1 ? 11 
HELX_P HELX_P26 AC8 SER A 569 ? ILE A 573 ? SER A 832 ILE A 836 5 ? 5  
HELX_P HELX_P27 AC9 GLY A 577 ? CYS A 584 ? GLY A 840 CYS A 847 1 ? 8  
HELX_P HELX_P28 AD1 LEU A 590 ? ASN A 599 ? LEU A 853 ASN A 862 1 ? 10 
HELX_P HELX_P29 AD2 ASN A 599 ? GLY A 612 ? ASN A 862 GLY A 875 1 ? 14 
HELX_P HELX_P30 AD3 MET A 623 ? ARG A 627 ? MET A 886 ARG A 890 5 ? 5  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1 metalc ? ? A GLU 175 OE1 ? ? ? 1_555 C ZN . ZN ? ? A GLU 438 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.031 ? ? 
metalc2 metalc ? ? A HIS 179 NE2 ? ? ? 1_555 C ZN . ZN ? ? A HIS 442 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.056 ? ? 
metalc3 metalc ? ? A CYS 184 SG  ? ? ? 1_555 C ZN . ZN ? ? A CYS 447 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.265 ? ? 
metalc4 metalc ? ? A CYS 187 SG  ? ? ? 1_555 C ZN . ZN ? ? A CYS 450 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.542 ? ? 
metalc5 metalc ? ? A HIS 449 NE2 ? ? ? 1_555 B ZN . ZN ? ? A HIS 712 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.087 ? ? 
metalc6 metalc ? ? A HIS 451 NE2 ? ? ? 1_555 B ZN . ZN ? ? A HIS 714 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.044 ? ? 
metalc7 metalc ? ? A CYS 465 SG  ? ? ? 1_555 B ZN . ZN ? ? A CYS 728 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.346 ? ? 
metalc8 metalc ? ? A CYS 584 SG  ? ? ? 1_555 B ZN . ZN ? ? A CYS 847 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.338 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  OE1 ? A GLU 175 ? A GLU 438 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 NE2 ? A HIS 179 ? A HIS 442 ? 1_555 109.0 ? 
2  OE1 ? A GLU 175 ? A GLU 438 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 184 ? A CYS 447 ? 1_555 111.7 ? 
3  NE2 ? A HIS 179 ? A HIS 442 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 184 ? A CYS 447 ? 1_555 113.9 ? 
4  OE1 ? A GLU 175 ? A GLU 438 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 89.0  ? 
5  NE2 ? A HIS 179 ? A HIS 442 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 117.7 ? 
6  SG  ? A CYS 184 ? A CYS 447 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 112.7 ? 
7  NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 NE2 ? A HIS 451 ? A HIS 714 ? 1_555 101.4 ? 
8  NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 465 ? A CYS 728 ? 1_555 105.5 ? 
9  NE2 ? A HIS 451 ? A HIS 714 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 465 ? A CYS 728 ? 1_555 109.3 ? 
10 NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 104.6 ? 
11 NE2 ? A HIS 451 ? A HIS 714 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 115.9 ? 
12 SG  ? A CYS 465 ? A CYS 728 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 118.0 ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 3 ? 
AA2 ? 2 ? 
AA3 ? 2 ? 
AA4 ? 2 ? 
AA5 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA5 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ALA A 41  ? GLU A 47  ? ALA A 304 GLU A 310 
AA1 2 VAL A 326 ? SER A 331 ? VAL A 589 SER A 594 
AA1 3 VAL A 315 ? ARG A 319 ? VAL A 578 ARG A 582 
AA2 1 MET A 57  ? VAL A 58  ? MET A 320 VAL A 321 
AA2 2 ILE A 477 ? SER A 478 ? ILE A 740 SER A 741 
AA3 1 ASN A 190 ? MET A 191 ? ASN A 453 MET A 454 
AA3 2 TRP A 212 ? TYR A 213 ? TRP A 475 TYR A 476 
AA4 1 MET A 395 ? SER A 398 ? MET A 658 SER A 661 
AA4 2 ASP A 401 ? VAL A 404 ? ASP A 664 VAL A 667 
AA5 1 HIS A 449 ? ILE A 454 ? HIS A 712 ILE A 717 
AA5 2 VAL A 460 ? CYS A 465 ? VAL A 723 CYS A 728 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N TYR A 46  ? N TYR A 309 O MET A 327 ? O MET A 590 
AA1 2 3 O ILE A 330 ? O ILE A 593 N VAL A 315 ? N VAL A 578 
AA2 1 2 N MET A 57  ? N MET A 320 O SER A 478 ? O SER A 741 
AA3 1 2 N ASN A 190 ? N ASN A 453 O TYR A 213 ? O TYR A 476 
AA4 1 2 N SER A 398 ? N SER A 661 O ASP A 401 ? O ASP A 664 
AA5 1 2 N LEU A 453 ? N LEU A 716 O LEU A 461 ? O LEU A 724 
# 
_pdbx_entry_details.entry_id                   7I28 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_close_contact.id               1 
_pdbx_validate_close_contact.PDB_model_num    1 
_pdbx_validate_close_contact.auth_atom_id_1   OD1 
_pdbx_validate_close_contact.auth_asym_id_1   A 
_pdbx_validate_close_contact.auth_comp_id_1   ASP 
_pdbx_validate_close_contact.auth_seq_id_1    534 
_pdbx_validate_close_contact.PDB_ins_code_1   ? 
_pdbx_validate_close_contact.label_alt_id_1   ? 
_pdbx_validate_close_contact.auth_atom_id_2   O2 
_pdbx_validate_close_contact.auth_asym_id_2   A 
_pdbx_validate_close_contact.auth_comp_id_2   PO4 
_pdbx_validate_close_contact.auth_seq_id_2    1007 
_pdbx_validate_close_contact.PDB_ins_code_2   ? 
_pdbx_validate_close_contact.label_alt_id_2   ? 
_pdbx_validate_close_contact.dist             2.15 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 360 ? ? -88.56  42.54  
2 1 GLU A 448 ? ? -133.43 -32.57 
3 1 LEU A 504 ? ? 80.46   -41.13 
4 1 TYR A 573 ? ? -97.73  -64.05 
5 1 GLN A 598 ? ? 73.39   157.00 
6 1 SER A 791 ? ? -172.31 99.35  
7 1 THR A 805 ? ? 176.16  168.02 
8 1 ASP A 808 ? ? -39.39  131.83 
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A MES 1003 ? D MES . 
2 1 A HOH 1159 ? N HOH . 
3 1 A HOH 1295 ? N HOH . 
4 1 A HOH 1380 ? N HOH . 
# 
_pdbx_distant_solvent_atoms.id                                1 
_pdbx_distant_solvent_atoms.PDB_model_num                     1 
_pdbx_distant_solvent_atoms.auth_atom_id                      O 
_pdbx_distant_solvent_atoms.label_alt_id                      ? 
_pdbx_distant_solvent_atoms.auth_asym_id                      A 
_pdbx_distant_solvent_atoms.auth_comp_id                      HOH 
_pdbx_distant_solvent_atoms.auth_seq_id                       1390 
_pdbx_distant_solvent_atoms.PDB_ins_code                      ? 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance   6.41 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance          . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY 264 ? A GLY 1   
2  1 Y 1 A PRO 265 ? A PRO 2   
3  1 Y 1 A GLY 266 ? A GLY 3   
4  1 Y 1 A ILE 267 ? A ILE 4   
5  1 Y 1 A GLU 268 ? A GLU 5   
6  1 Y 1 A SER 269 ? A SER 6   
7  1 Y 1 A GLU 270 ? A GLU 7   
8  1 Y 1 A THR 271 ? A THR 8   
9  1 Y 1 A PRO 272 ? A PRO 9   
10 1 Y 1 A LYS 312 ? A LYS 49  
11 1 Y 1 A GLN 313 ? A GLN 50  
12 1 Y 1 A THR 314 ? A THR 51  
13 1 Y 1 A GLY 315 ? A GLY 52  
14 1 Y 1 A SER 316 ? A SER 53  
15 1 Y 1 A ASP 345 ? A ASP 82  
16 1 Y 1 A THR 346 ? A THR 83  
17 1 Y 1 A THR 347 ? A THR 84  
18 1 Y 1 A PRO 348 ? A PRO 85  
19 1 Y 1 A PHE 349 ? A PHE 86  
20 1 Y 1 A GLY 350 ? A GLY 87  
21 1 Y 1 A GLN 351 ? A GLN 88  
22 1 Y 1 A GLN 352 ? A GLN 89  
23 1 Y 1 A ARG 353 ? A ARG 90  
24 1 Y 1 A VAL 354 ? A VAL 91  
25 1 Y 1 A PHE 355 ? A PHE 92  
26 1 Y 1 A LYS 356 ? A LYS 93  
27 1 Y 1 A PHE 413 ? A PHE 150 
28 1 Y 1 A THR 414 ? A THR 151 
29 1 Y 1 A ASP 415 ? A ASP 152 
30 1 Y 1 A GLU 416 ? A GLU 153 
31 1 Y 1 A ASN 417 ? A ASN 154 
32 1 Y 1 A LYS 418 ? A LYS 155 
33 1 Y 1 A GLY 456 ? A GLY 193 
34 1 Y 1 A LYS 457 ? A LYS 194 
35 1 Y 1 A ARG 458 ? A ARG 195 
36 1 Y 1 A GLU 459 ? A GLU 196 
37 1 Y 1 A LYS 460 ? A LYS 197 
38 1 Y 1 A LYS 461 ? A LYS 198 
39 1 Y 1 A LEU 462 ? A LEU 199 
40 1 Y 1 A GLY 463 ? A GLY 200 
41 1 Y 1 A GLU 464 ? A GLU 201 
42 1 Y 1 A PHE 465 ? A PHE 202 
43 1 Y 1 A GLY 466 ? A GLY 203 
44 1 Y 1 A LYS 467 ? A LYS 204 
45 1 Y 1 A ALA 468 ? A ALA 205 
46 1 Y 1 A LYS 469 ? A LYS 206 
47 1 Y 1 A GLY 470 ? A GLY 207 
48 1 Y 1 A SER 471 ? A SER 208 
49 1 Y 1 A ARG 472 ? A ARG 209 
50 1 Y 1 A PRO 585 ? A PRO 322 
51 1 Y 1 A ARG 586 ? A ARG 323 
52 1 Y 1 A GLY 587 ? A GLY 324 
53 1 Y 1 A THR 794 ? A THR 531 
54 1 Y 1 A TRP 795 ? A TRP 532 
55 1 Y 1 A SER 796 ? A SER 533 
56 1 Y 1 A ILE 797 ? A ILE 534 
57 1 Y 1 A HIS 798 ? A HIS 535 
58 1 Y 1 A GLU 892 ? A GLU 629 
59 1 Y 1 A GLU 893 ? A GLU 630 
60 1 Y 1 A GLU 894 ? A GLU 631 
61 1 Y 1 A GLU 895 ? A GLU 632 
62 1 Y 1 A ALA 896 ? A ALA 633 
63 1 Y 1 A GLY 897 ? A GLY 634 
64 1 Y 1 A VAL 898 ? A VAL 635 
65 1 Y 1 A LEU 899 ? A LEU 636 
66 1 Y 1 A TRP 900 ? A TRP 637 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CL  CL   CL N N 74  
CYS N    N  N N 75  
CYS CA   C  N R 76  
CYS C    C  N N 77  
CYS O    O  N N 78  
CYS CB   C  N N 79  
CYS SG   S  N N 80  
CYS OXT  O  N N 81  
CYS H    H  N N 82  
CYS H2   H  N N 83  
CYS HA   H  N N 84  
CYS HB2  H  N N 85  
CYS HB3  H  N N 86  
CYS HG   H  N N 87  
CYS HXT  H  N N 88  
DMS S    S  N N 89  
DMS O    O  N N 90  
DMS C1   C  N N 91  
DMS C2   C  N N 92  
DMS H11  H  N N 93  
DMS H12  H  N N 94  
DMS H13  H  N N 95  
DMS H21  H  N N 96  
DMS H22  H  N N 97  
DMS H23  H  N N 98  
GLN N    N  N N 99  
GLN CA   C  N S 100 
GLN C    C  N N 101 
GLN O    O  N N 102 
GLN CB   C  N N 103 
GLN CG   C  N N 104 
GLN CD   C  N N 105 
GLN OE1  O  N N 106 
GLN NE2  N  N N 107 
GLN OXT  O  N N 108 
GLN H    H  N N 109 
GLN H2   H  N N 110 
GLN HA   H  N N 111 
GLN HB2  H  N N 112 
GLN HB3  H  N N 113 
GLN HG2  H  N N 114 
GLN HG3  H  N N 115 
GLN HE21 H  N N 116 
GLN HE22 H  N N 117 
GLN HXT  H  N N 118 
GLU N    N  N N 119 
GLU CA   C  N S 120 
GLU C    C  N N 121 
GLU O    O  N N 122 
GLU CB   C  N N 123 
GLU CG   C  N N 124 
GLU CD   C  N N 125 
GLU OE1  O  N N 126 
GLU OE2  O  N N 127 
GLU OXT  O  N N 128 
GLU H    H  N N 129 
GLU H2   H  N N 130 
GLU HA   H  N N 131 
GLU HB2  H  N N 132 
GLU HB3  H  N N 133 
GLU HG2  H  N N 134 
GLU HG3  H  N N 135 
GLU HE2  H  N N 136 
GLU HXT  H  N N 137 
GLY N    N  N N 138 
GLY CA   C  N N 139 
GLY C    C  N N 140 
GLY O    O  N N 141 
GLY OXT  O  N N 142 
GLY H    H  N N 143 
GLY H2   H  N N 144 
GLY HA2  H  N N 145 
GLY HA3  H  N N 146 
GLY HXT  H  N N 147 
HIS N    N  N N 148 
HIS CA   C  N S 149 
HIS C    C  N N 150 
HIS O    O  N N 151 
HIS CB   C  N N 152 
HIS CG   C  Y N 153 
HIS ND1  N  Y N 154 
HIS CD2  C  Y N 155 
HIS CE1  C  Y N 156 
HIS NE2  N  Y N 157 
HIS OXT  O  N N 158 
HIS H    H  N N 159 
HIS H2   H  N N 160 
HIS HA   H  N N 161 
HIS HB2  H  N N 162 
HIS HB3  H  N N 163 
HIS HD1  H  N N 164 
HIS HD2  H  N N 165 
HIS HE1  H  N N 166 
HIS HE2  H  N N 167 
HIS HXT  H  N N 168 
HOH O    O  N N 169 
HOH H1   H  N N 170 
HOH H2   H  N N 171 
ILE N    N  N N 172 
ILE CA   C  N S 173 
ILE C    C  N N 174 
ILE O    O  N N 175 
ILE CB   C  N S 176 
ILE CG1  C  N N 177 
ILE CG2  C  N N 178 
ILE CD1  C  N N 179 
ILE OXT  O  N N 180 
ILE H    H  N N 181 
ILE H2   H  N N 182 
ILE HA   H  N N 183 
ILE HB   H  N N 184 
ILE HG12 H  N N 185 
ILE HG13 H  N N 186 
ILE HG21 H  N N 187 
ILE HG22 H  N N 188 
ILE HG23 H  N N 189 
ILE HD11 H  N N 190 
ILE HD12 H  N N 191 
ILE HD13 H  N N 192 
ILE HXT  H  N N 193 
LEU N    N  N N 194 
LEU CA   C  N S 195 
LEU C    C  N N 196 
LEU O    O  N N 197 
LEU CB   C  N N 198 
LEU CG   C  N N 199 
LEU CD1  C  N N 200 
LEU CD2  C  N N 201 
LEU OXT  O  N N 202 
LEU H    H  N N 203 
LEU H2   H  N N 204 
LEU HA   H  N N 205 
LEU HB2  H  N N 206 
LEU HB3  H  N N 207 
LEU HG   H  N N 208 
LEU HD11 H  N N 209 
LEU HD12 H  N N 210 
LEU HD13 H  N N 211 
LEU HD21 H  N N 212 
LEU HD22 H  N N 213 
LEU HD23 H  N N 214 
LEU HXT  H  N N 215 
LYS N    N  N N 216 
LYS CA   C  N S 217 
LYS C    C  N N 218 
LYS O    O  N N 219 
LYS CB   C  N N 220 
LYS CG   C  N N 221 
LYS CD   C  N N 222 
LYS CE   C  N N 223 
LYS NZ   N  N N 224 
LYS OXT  O  N N 225 
LYS H    H  N N 226 
LYS H2   H  N N 227 
LYS HA   H  N N 228 
LYS HB2  H  N N 229 
LYS HB3  H  N N 230 
LYS HG2  H  N N 231 
LYS HG3  H  N N 232 
LYS HD2  H  N N 233 
LYS HD3  H  N N 234 
LYS HE2  H  N N 235 
LYS HE3  H  N N 236 
LYS HZ1  H  N N 237 
LYS HZ2  H  N N 238 
LYS HZ3  H  N N 239 
LYS HXT  H  N N 240 
MES O1   O  N N 241 
MES C2   C  N N 242 
MES C3   C  N N 243 
MES N4   N  N N 244 
MES C5   C  N N 245 
MES C6   C  N N 246 
MES C7   C  N N 247 
MES C8   C  N N 248 
MES S    S  N N 249 
MES O1S  O  N N 250 
MES O2S  O  N N 251 
MES O3S  O  N N 252 
MES H21  H  N N 253 
MES H22  H  N N 254 
MES H31  H  N N 255 
MES H32  H  N N 256 
MES HN4  H  N N 257 
MES H51  H  N N 258 
MES H52  H  N N 259 
MES H61  H  N N 260 
MES H62  H  N N 261 
MES H71  H  N N 262 
MES H72  H  N N 263 
MES H81  H  N N 264 
MES H82  H  N N 265 
MET N    N  N N 266 
MET CA   C  N S 267 
MET C    C  N N 268 
MET O    O  N N 269 
MET CB   C  N N 270 
MET CG   C  N N 271 
MET SD   S  N N 272 
MET CE   C  N N 273 
MET OXT  O  N N 274 
MET H    H  N N 275 
MET H2   H  N N 276 
MET HA   H  N N 277 
MET HB2  H  N N 278 
MET HB3  H  N N 279 
MET HG2  H  N N 280 
MET HG3  H  N N 281 
MET HE1  H  N N 282 
MET HE2  H  N N 283 
MET HE3  H  N N 284 
MET HXT  H  N N 285 
PEG C1   C  N N 286 
PEG O1   O  N N 287 
PEG C2   C  N N 288 
PEG O2   O  N N 289 
PEG C3   C  N N 290 
PEG C4   C  N N 291 
PEG O4   O  N N 292 
PEG H11  H  N N 293 
PEG H12  H  N N 294 
PEG HO1  H  N N 295 
PEG H21  H  N N 296 
PEG H22  H  N N 297 
PEG H31  H  N N 298 
PEG H32  H  N N 299 
PEG H41  H  N N 300 
PEG H42  H  N N 301 
PEG HO4  H  N N 302 
PHE N    N  N N 303 
PHE CA   C  N S 304 
PHE C    C  N N 305 
PHE O    O  N N 306 
PHE CB   C  N N 307 
PHE CG   C  Y N 308 
PHE CD1  C  Y N 309 
PHE CD2  C  Y N 310 
PHE CE1  C  Y N 311 
PHE CE2  C  Y N 312 
PHE CZ   C  Y N 313 
PHE OXT  O  N N 314 
PHE H    H  N N 315 
PHE H2   H  N N 316 
PHE HA   H  N N 317 
PHE HB2  H  N N 318 
PHE HB3  H  N N 319 
PHE HD1  H  N N 320 
PHE HD2  H  N N 321 
PHE HE1  H  N N 322 
PHE HE2  H  N N 323 
PHE HZ   H  N N 324 
PHE HXT  H  N N 325 
PO4 P    P  N N 326 
PO4 O1   O  N N 327 
PO4 O2   O  N N 328 
PO4 O3   O  N N 329 
PO4 O4   O  N N 330 
PRO N    N  N N 331 
PRO CA   C  N S 332 
PRO C    C  N N 333 
PRO O    O  N N 334 
PRO CB   C  N N 335 
PRO CG   C  N N 336 
PRO CD   C  N N 337 
PRO OXT  O  N N 338 
PRO H    H  N N 339 
PRO HA   H  N N 340 
PRO HB2  H  N N 341 
PRO HB3  H  N N 342 
PRO HG2  H  N N 343 
PRO HG3  H  N N 344 
PRO HD2  H  N N 345 
PRO HD3  H  N N 346 
PRO HXT  H  N N 347 
SER N    N  N N 348 
SER CA   C  N S 349 
SER C    C  N N 350 
SER O    O  N N 351 
SER CB   C  N N 352 
SER OG   O  N N 353 
SER OXT  O  N N 354 
SER H    H  N N 355 
SER H2   H  N N 356 
SER HA   H  N N 357 
SER HB2  H  N N 358 
SER HB3  H  N N 359 
SER HG   H  N N 360 
SER HXT  H  N N 361 
THR N    N  N N 362 
THR CA   C  N S 363 
THR C    C  N N 364 
THR O    O  N N 365 
THR CB   C  N R 366 
THR OG1  O  N N 367 
THR CG2  C  N N 368 
THR OXT  O  N N 369 
THR H    H  N N 370 
THR H2   H  N N 371 
THR HA   H  N N 372 
THR HB   H  N N 373 
THR HG1  H  N N 374 
THR HG21 H  N N 375 
THR HG22 H  N N 376 
THR HG23 H  N N 377 
THR HXT  H  N N 378 
TRP N    N  N N 379 
TRP CA   C  N S 380 
TRP C    C  N N 381 
TRP O    O  N N 382 
TRP CB   C  N N 383 
TRP CG   C  Y N 384 
TRP CD1  C  Y N 385 
TRP CD2  C  Y N 386 
TRP NE1  N  Y N 387 
TRP CE2  C  Y N 388 
TRP CE3  C  Y N 389 
TRP CZ2  C  Y N 390 
TRP CZ3  C  Y N 391 
TRP CH2  C  Y N 392 
TRP OXT  O  N N 393 
TRP H    H  N N 394 
TRP H2   H  N N 395 
TRP HA   H  N N 396 
TRP HB2  H  N N 397 
TRP HB3  H  N N 398 
TRP HD1  H  N N 399 
TRP HE1  H  N N 400 
TRP HE3  H  N N 401 
TRP HZ2  H  N N 402 
TRP HZ3  H  N N 403 
TRP HH2  H  N N 404 
TRP HXT  H  N N 405 
TYR N    N  N N 406 
TYR CA   C  N S 407 
TYR C    C  N N 408 
TYR O    O  N N 409 
TYR CB   C  N N 410 
TYR CG   C  Y N 411 
TYR CD1  C  Y N 412 
TYR CD2  C  Y N 413 
TYR CE1  C  Y N 414 
TYR CE2  C  Y N 415 
TYR CZ   C  Y N 416 
TYR OH   O  N N 417 
TYR OXT  O  N N 418 
TYR H    H  N N 419 
TYR H2   H  N N 420 
TYR HA   H  N N 421 
TYR HB2  H  N N 422 
TYR HB3  H  N N 423 
TYR HD1  H  N N 424 
TYR HD2  H  N N 425 
TYR HE1  H  N N 426 
TYR HE2  H  N N 427 
TYR HH   H  N N 428 
TYR HXT  H  N N 429 
VAL N    N  N N 430 
VAL CA   C  N S 431 
VAL C    C  N N 432 
VAL O    O  N N 433 
VAL CB   C  N N 434 
VAL CG1  C  N N 435 
VAL CG2  C  N N 436 
VAL OXT  O  N N 437 
VAL H    H  N N 438 
VAL H2   H  N N 439 
VAL HA   H  N N 440 
VAL HB   H  N N 441 
VAL HG11 H  N N 442 
VAL HG12 H  N N 443 
VAL HG13 H  N N 444 
VAL HG21 H  N N 445 
VAL HG22 H  N N 446 
VAL HG23 H  N N 447 
VAL HXT  H  N N 448 
X0S C4   C  Y N 449 
X0S C5   C  Y N 450 
X0S C6   C  Y N 451 
X0S C7   C  N N 452 
X0S N1   N  N N 453 
X0S C3   C  Y N 454 
X0S C1   C  Y N 455 
X0S C2   C  Y N 456 
X0S O1   O  N N 457 
X0S O2   O  N N 458 
X0S S1   S  N N 459 
X0S CL1  CL N N 460 
X0S H4   H  N N 461 
X0S H7   H  N N 462 
X0S H8   H  N N 463 
X0S H6   H  N N 464 
X0S H5   H  N N 465 
X0S H3   H  N N 466 
X0S H1   H  N N 467 
X0S H2   H  N N 468 
ZN  ZN   ZN N N 469 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
DMS S   O    doub N N 83  
DMS S   C1   sing N N 84  
DMS S   C2   sing N N 85  
DMS C1  H11  sing N N 86  
DMS C1  H12  sing N N 87  
DMS C1  H13  sing N N 88  
DMS C2  H21  sing N N 89  
DMS C2  H22  sing N N 90  
DMS C2  H23  sing N N 91  
GLN N   CA   sing N N 92  
GLN N   H    sing N N 93  
GLN N   H2   sing N N 94  
GLN CA  C    sing N N 95  
GLN CA  CB   sing N N 96  
GLN CA  HA   sing N N 97  
GLN C   O    doub N N 98  
GLN C   OXT  sing N N 99  
GLN CB  CG   sing N N 100 
GLN CB  HB2  sing N N 101 
GLN CB  HB3  sing N N 102 
GLN CG  CD   sing N N 103 
GLN CG  HG2  sing N N 104 
GLN CG  HG3  sing N N 105 
GLN CD  OE1  doub N N 106 
GLN CD  NE2  sing N N 107 
GLN NE2 HE21 sing N N 108 
GLN NE2 HE22 sing N N 109 
GLN OXT HXT  sing N N 110 
GLU N   CA   sing N N 111 
GLU N   H    sing N N 112 
GLU N   H2   sing N N 113 
GLU CA  C    sing N N 114 
GLU CA  CB   sing N N 115 
GLU CA  HA   sing N N 116 
GLU C   O    doub N N 117 
GLU C   OXT  sing N N 118 
GLU CB  CG   sing N N 119 
GLU CB  HB2  sing N N 120 
GLU CB  HB3  sing N N 121 
GLU CG  CD   sing N N 122 
GLU CG  HG2  sing N N 123 
GLU CG  HG3  sing N N 124 
GLU CD  OE1  doub N N 125 
GLU CD  OE2  sing N N 126 
GLU OE2 HE2  sing N N 127 
GLU OXT HXT  sing N N 128 
GLY N   CA   sing N N 129 
GLY N   H    sing N N 130 
GLY N   H2   sing N N 131 
GLY CA  C    sing N N 132 
GLY CA  HA2  sing N N 133 
GLY CA  HA3  sing N N 134 
GLY C   O    doub N N 135 
GLY C   OXT  sing N N 136 
GLY OXT HXT  sing N N 137 
HIS N   CA   sing N N 138 
HIS N   H    sing N N 139 
HIS N   H2   sing N N 140 
HIS CA  C    sing N N 141 
HIS CA  CB   sing N N 142 
HIS CA  HA   sing N N 143 
HIS C   O    doub N N 144 
HIS C   OXT  sing N N 145 
HIS CB  CG   sing N N 146 
HIS CB  HB2  sing N N 147 
HIS CB  HB3  sing N N 148 
HIS CG  ND1  sing Y N 149 
HIS CG  CD2  doub Y N 150 
HIS ND1 CE1  doub Y N 151 
HIS ND1 HD1  sing N N 152 
HIS CD2 NE2  sing Y N 153 
HIS CD2 HD2  sing N N 154 
HIS CE1 NE2  sing Y N 155 
HIS CE1 HE1  sing N N 156 
HIS NE2 HE2  sing N N 157 
HIS OXT HXT  sing N N 158 
HOH O   H1   sing N N 159 
HOH O   H2   sing N N 160 
ILE N   CA   sing N N 161 
ILE N   H    sing N N 162 
ILE N   H2   sing N N 163 
ILE CA  C    sing N N 164 
ILE CA  CB   sing N N 165 
ILE CA  HA   sing N N 166 
ILE C   O    doub N N 167 
ILE C   OXT  sing N N 168 
ILE CB  CG1  sing N N 169 
ILE CB  CG2  sing N N 170 
ILE CB  HB   sing N N 171 
ILE CG1 CD1  sing N N 172 
ILE CG1 HG12 sing N N 173 
ILE CG1 HG13 sing N N 174 
ILE CG2 HG21 sing N N 175 
ILE CG2 HG22 sing N N 176 
ILE CG2 HG23 sing N N 177 
ILE CD1 HD11 sing N N 178 
ILE CD1 HD12 sing N N 179 
ILE CD1 HD13 sing N N 180 
ILE OXT HXT  sing N N 181 
LEU N   CA   sing N N 182 
LEU N   H    sing N N 183 
LEU N   H2   sing N N 184 
LEU CA  C    sing N N 185 
LEU CA  CB   sing N N 186 
LEU CA  HA   sing N N 187 
LEU C   O    doub N N 188 
LEU C   OXT  sing N N 189 
LEU CB  CG   sing N N 190 
LEU CB  HB2  sing N N 191 
LEU CB  HB3  sing N N 192 
LEU CG  CD1  sing N N 193 
LEU CG  CD2  sing N N 194 
LEU CG  HG   sing N N 195 
LEU CD1 HD11 sing N N 196 
LEU CD1 HD12 sing N N 197 
LEU CD1 HD13 sing N N 198 
LEU CD2 HD21 sing N N 199 
LEU CD2 HD22 sing N N 200 
LEU CD2 HD23 sing N N 201 
LEU OXT HXT  sing N N 202 
LYS N   CA   sing N N 203 
LYS N   H    sing N N 204 
LYS N   H2   sing N N 205 
LYS CA  C    sing N N 206 
LYS CA  CB   sing N N 207 
LYS CA  HA   sing N N 208 
LYS C   O    doub N N 209 
LYS C   OXT  sing N N 210 
LYS CB  CG   sing N N 211 
LYS CB  HB2  sing N N 212 
LYS CB  HB3  sing N N 213 
LYS CG  CD   sing N N 214 
LYS CG  HG2  sing N N 215 
LYS CG  HG3  sing N N 216 
LYS CD  CE   sing N N 217 
LYS CD  HD2  sing N N 218 
LYS CD  HD3  sing N N 219 
LYS CE  NZ   sing N N 220 
LYS CE  HE2  sing N N 221 
LYS CE  HE3  sing N N 222 
LYS NZ  HZ1  sing N N 223 
LYS NZ  HZ2  sing N N 224 
LYS NZ  HZ3  sing N N 225 
LYS OXT HXT  sing N N 226 
MES O1  C2   sing N N 227 
MES O1  C6   sing N N 228 
MES C2  C3   sing N N 229 
MES C2  H21  sing N N 230 
MES C2  H22  sing N N 231 
MES C3  N4   sing N N 232 
MES C3  H31  sing N N 233 
MES C3  H32  sing N N 234 
MES N4  C5   sing N N 235 
MES N4  C7   sing N N 236 
MES N4  HN4  sing N N 237 
MES C5  C6   sing N N 238 
MES C5  H51  sing N N 239 
MES C5  H52  sing N N 240 
MES C6  H61  sing N N 241 
MES C6  H62  sing N N 242 
MES C7  C8   sing N N 243 
MES C7  H71  sing N N 244 
MES C7  H72  sing N N 245 
MES C8  S    sing N N 246 
MES C8  H81  sing N N 247 
MES C8  H82  sing N N 248 
MES S   O1S  doub N N 249 
MES S   O2S  doub N N 250 
MES S   O3S  sing N N 251 
MET N   CA   sing N N 252 
MET N   H    sing N N 253 
MET N   H2   sing N N 254 
MET CA  C    sing N N 255 
MET CA  CB   sing N N 256 
MET CA  HA   sing N N 257 
MET C   O    doub N N 258 
MET C   OXT  sing N N 259 
MET CB  CG   sing N N 260 
MET CB  HB2  sing N N 261 
MET CB  HB3  sing N N 262 
MET CG  SD   sing N N 263 
MET CG  HG2  sing N N 264 
MET CG  HG3  sing N N 265 
MET SD  CE   sing N N 266 
MET CE  HE1  sing N N 267 
MET CE  HE2  sing N N 268 
MET CE  HE3  sing N N 269 
MET OXT HXT  sing N N 270 
PEG C1  O1   sing N N 271 
PEG C1  C2   sing N N 272 
PEG C1  H11  sing N N 273 
PEG C1  H12  sing N N 274 
PEG O1  HO1  sing N N 275 
PEG C2  O2   sing N N 276 
PEG C2  H21  sing N N 277 
PEG C2  H22  sing N N 278 
PEG O2  C3   sing N N 279 
PEG C3  C4   sing N N 280 
PEG C3  H31  sing N N 281 
PEG C3  H32  sing N N 282 
PEG C4  O4   sing N N 283 
PEG C4  H41  sing N N 284 
PEG C4  H42  sing N N 285 
PEG O4  HO4  sing N N 286 
PHE N   CA   sing N N 287 
PHE N   H    sing N N 288 
PHE N   H2   sing N N 289 
PHE CA  C    sing N N 290 
PHE CA  CB   sing N N 291 
PHE CA  HA   sing N N 292 
PHE C   O    doub N N 293 
PHE C   OXT  sing N N 294 
PHE CB  CG   sing N N 295 
PHE CB  HB2  sing N N 296 
PHE CB  HB3  sing N N 297 
PHE CG  CD1  doub Y N 298 
PHE CG  CD2  sing Y N 299 
PHE CD1 CE1  sing Y N 300 
PHE CD1 HD1  sing N N 301 
PHE CD2 CE2  doub Y N 302 
PHE CD2 HD2  sing N N 303 
PHE CE1 CZ   doub Y N 304 
PHE CE1 HE1  sing N N 305 
PHE CE2 CZ   sing Y N 306 
PHE CE2 HE2  sing N N 307 
PHE CZ  HZ   sing N N 308 
PHE OXT HXT  sing N N 309 
PO4 P   O1   doub N N 310 
PO4 P   O2   sing N N 311 
PO4 P   O3   sing N N 312 
PO4 P   O4   sing N N 313 
PRO N   CA   sing N N 314 
PRO N   CD   sing N N 315 
PRO N   H    sing N N 316 
PRO CA  C    sing N N 317 
PRO CA  CB   sing N N 318 
PRO CA  HA   sing N N 319 
PRO C   O    doub N N 320 
PRO C   OXT  sing N N 321 
PRO CB  CG   sing N N 322 
PRO CB  HB2  sing N N 323 
PRO CB  HB3  sing N N 324 
PRO CG  CD   sing N N 325 
PRO CG  HG2  sing N N 326 
PRO CG  HG3  sing N N 327 
PRO CD  HD2  sing N N 328 
PRO CD  HD3  sing N N 329 
PRO OXT HXT  sing N N 330 
SER N   CA   sing N N 331 
SER N   H    sing N N 332 
SER N   H2   sing N N 333 
SER CA  C    sing N N 334 
SER CA  CB   sing N N 335 
SER CA  HA   sing N N 336 
SER C   O    doub N N 337 
SER C   OXT  sing N N 338 
SER CB  OG   sing N N 339 
SER CB  HB2  sing N N 340 
SER CB  HB3  sing N N 341 
SER OG  HG   sing N N 342 
SER OXT HXT  sing N N 343 
THR N   CA   sing N N 344 
THR N   H    sing N N 345 
THR N   H2   sing N N 346 
THR CA  C    sing N N 347 
THR CA  CB   sing N N 348 
THR CA  HA   sing N N 349 
THR C   O    doub N N 350 
THR C   OXT  sing N N 351 
THR CB  OG1  sing N N 352 
THR CB  CG2  sing N N 353 
THR CB  HB   sing N N 354 
THR OG1 HG1  sing N N 355 
THR CG2 HG21 sing N N 356 
THR CG2 HG22 sing N N 357 
THR CG2 HG23 sing N N 358 
THR OXT HXT  sing N N 359 
TRP N   CA   sing N N 360 
TRP N   H    sing N N 361 
TRP N   H2   sing N N 362 
TRP CA  C    sing N N 363 
TRP CA  CB   sing N N 364 
TRP CA  HA   sing N N 365 
TRP C   O    doub N N 366 
TRP C   OXT  sing N N 367 
TRP CB  CG   sing N N 368 
TRP CB  HB2  sing N N 369 
TRP CB  HB3  sing N N 370 
TRP CG  CD1  doub Y N 371 
TRP CG  CD2  sing Y N 372 
TRP CD1 NE1  sing Y N 373 
TRP CD1 HD1  sing N N 374 
TRP CD2 CE2  doub Y N 375 
TRP CD2 CE3  sing Y N 376 
TRP NE1 CE2  sing Y N 377 
TRP NE1 HE1  sing N N 378 
TRP CE2 CZ2  sing Y N 379 
TRP CE3 CZ3  doub Y N 380 
TRP CE3 HE3  sing N N 381 
TRP CZ2 CH2  doub Y N 382 
TRP CZ2 HZ2  sing N N 383 
TRP CZ3 CH2  sing Y N 384 
TRP CZ3 HZ3  sing N N 385 
TRP CH2 HH2  sing N N 386 
TRP OXT HXT  sing N N 387 
TYR N   CA   sing N N 388 
TYR N   H    sing N N 389 
TYR N   H2   sing N N 390 
TYR CA  C    sing N N 391 
TYR CA  CB   sing N N 392 
TYR CA  HA   sing N N 393 
TYR C   O    doub N N 394 
TYR C   OXT  sing N N 395 
TYR CB  CG   sing N N 396 
TYR CB  HB2  sing N N 397 
TYR CB  HB3  sing N N 398 
TYR CG  CD1  doub Y N 399 
TYR CG  CD2  sing Y N 400 
TYR CD1 CE1  sing Y N 401 
TYR CD1 HD1  sing N N 402 
TYR CD2 CE2  doub Y N 403 
TYR CD2 HD2  sing N N 404 
TYR CE1 CZ   doub Y N 405 
TYR CE1 HE1  sing N N 406 
TYR CE2 CZ   sing Y N 407 
TYR CE2 HE2  sing N N 408 
TYR CZ  OH   sing N N 409 
TYR OH  HH   sing N N 410 
TYR OXT HXT  sing N N 411 
VAL N   CA   sing N N 412 
VAL N   H    sing N N 413 
VAL N   H2   sing N N 414 
VAL CA  C    sing N N 415 
VAL CA  CB   sing N N 416 
VAL CA  HA   sing N N 417 
VAL C   O    doub N N 418 
VAL C   OXT  sing N N 419 
VAL CB  CG1  sing N N 420 
VAL CB  CG2  sing N N 421 
VAL CB  HB   sing N N 422 
VAL CG1 HG11 sing N N 423 
VAL CG1 HG12 sing N N 424 
VAL CG1 HG13 sing N N 425 
VAL CG2 HG21 sing N N 426 
VAL CG2 HG22 sing N N 427 
VAL CG2 HG23 sing N N 428 
VAL OXT HXT  sing N N 429 
X0S O2  S1   doub N N 430 
X0S C2  C3   doub Y N 431 
X0S C2  C1   sing Y N 432 
X0S C3  C4   sing Y N 433 
X0S C1  C6   doub Y N 434 
X0S C4  C5   doub Y N 435 
X0S C6  C5   sing Y N 436 
X0S C6  CL1  sing N N 437 
X0S C5  S1   sing N N 438 
X0S S1  N1   sing N N 439 
X0S S1  O1   doub N N 440 
X0S N1  C7   sing N N 441 
X0S C4  H4   sing N N 442 
X0S C7  H7   sing N N 443 
X0S C7  H8   sing N N 444 
X0S C7  H6   sing N N 445 
X0S N1  H5   sing N N 446 
X0S C3  H3   sing N N 447 
X0S C1  H1   sing N N 448 
X0S C2  H2   sing N N 449 
# 
_pdbx_audit_support.ordinal                1 
_pdbx_audit_support.funding_organization   
'National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)' 
_pdbx_audit_support.grant_number           U19AI171292 
_pdbx_audit_support.country                'United States' 
# 
_pdbx_deposit_group.group_id            G_1002341 
_pdbx_deposit_group.group_description   
'Crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_pdbx_deposit_group.group_title         
'Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_pdbx_deposit_group.group_type          'changed state' 
# 
_atom_sites.entry_id                    7I28 
_atom_sites.fract_transf_matrix[1][1]   0.012113 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.008535 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.006743 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
# 
loop_
_atom_type.symbol 
C  
CL 
N  
O  
P  
S  
ZN 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . ASN A 1 10  ? -14.012 -6.674  -12.444 0.41 86.83  ? 273  ASN A N   1 
ATOM   2    C  CA  . ASN A 1 10  ? -13.719 -7.232  -11.087 0.41 87.00  ? 273  ASN A CA  1 
ATOM   3    C  C   . ASN A 1 10  ? -14.971 -7.030  -10.217 0.41 87.86  ? 273  ASN A C   1 
ATOM   4    O  O   . ASN A 1 10  ? -16.018 -7.605  -10.584 0.41 81.38  ? 273  ASN A O   1 
ATOM   5    C  CB  . ASN A 1 10  ? -12.413 -6.653  -10.522 0.41 88.45  ? 273  ASN A CB  1 
ATOM   6    C  CG  . ASN A 1 10  ? -11.877 -7.393  -9.311  0.41 87.73  ? 273  ASN A CG  1 
ATOM   7    O  OD1 . ASN A 1 10  ? -12.506 -8.320  -8.806  0.41 85.45  ? 273  ASN A OD1 1 
ATOM   8    N  ND2 . ASN A 1 10  ? -10.708 -6.991  -8.836  0.41 87.39  ? 273  ASN A ND2 1 
ATOM   9    N  N   . LEU A 1 11  ? -14.888 -6.225  -9.147  0.41 88.07  ? 274  LEU A N   1 
ATOM   10   C  CA  . LEU A 1 11  ? -15.944 -6.094  -8.101  0.41 85.97  ? 274  LEU A CA  1 
ATOM   11   C  C   . LEU A 1 11  ? -17.246 -5.567  -8.714  0.41 84.59  ? 274  LEU A C   1 
ATOM   12   O  O   . LEU A 1 11  ? -18.312 -5.847  -8.140  0.41 81.00  ? 274  LEU A O   1 
ATOM   13   C  CB  . LEU A 1 11  ? -15.451 -5.179  -6.974  0.41 87.56  ? 274  LEU A CB  1 
ATOM   14   C  CG  . LEU A 1 11  ? -14.597 -5.864  -5.908  0.41 90.22  ? 274  LEU A CG  1 
ATOM   15   C  CD1 . LEU A 1 11  ? -13.822 -4.842  -5.091  0.41 90.49  ? 274  LEU A CD1 1 
ATOM   16   C  CD2 . LEU A 1 11  ? -15.453 -6.736  -4.999  0.41 89.82  ? 274  LEU A CD2 1 
ATOM   17   N  N   . ASP A 1 12  ? -17.168 -4.837  -9.830  0.41 84.76  ? 275  ASP A N   1 
ATOM   18   C  CA  . ASP A 1 12  ? -18.359 -4.423  -10.619 0.41 93.02  ? 275  ASP A CA  1 
ATOM   19   C  C   . ASP A 1 12  ? -19.164 -5.678  -10.991 0.41 91.10  ? 275  ASP A C   1 
ATOM   20   O  O   . ASP A 1 12  ? -20.393 -5.675  -10.783 0.41 89.29  ? 275  ASP A O   1 
ATOM   21   C  CB  . ASP A 1 12  ? -17.959 -3.590  -11.844 0.41 98.54  ? 275  ASP A CB  1 
ATOM   22   C  CG  . ASP A 1 12  ? -17.211 -4.362  -12.920 0.41 102.81 ? 275  ASP A CG  1 
ATOM   23   O  OD1 . ASP A 1 12  ? -16.420 -5.265  -12.557 0.41 104.94 ? 275  ASP A OD1 1 
ATOM   24   O  OD2 . ASP A 1 12  ? -17.434 -4.063  -14.114 0.41 102.54 ? 275  ASP A OD2 1 
ATOM   25   N  N   . ILE A 1 13  ? -18.484 -6.728  -11.470 0.41 91.37  ? 276  ILE A N   1 
ATOM   26   C  CA  . ILE A 1 13  ? -19.101 -7.952  -12.069 0.41 87.55  ? 276  ILE A CA  1 
ATOM   27   C  C   . ILE A 1 13  ? -19.454 -8.958  -10.962 0.41 85.48  ? 276  ILE A C   1 
ATOM   28   O  O   . ILE A 1 13  ? -20.583 -9.492  -10.996 0.41 79.90  ? 276  ILE A O   1 
ATOM   29   C  CB  . ILE A 1 13  ? -18.164 -8.558  -13.139 0.41 87.52  ? 276  ILE A CB  1 
ATOM   30   C  CG1 . ILE A 1 13  ? -18.081 -7.667  -14.383 0.41 85.95  ? 276  ILE A CG1 1 
ATOM   31   C  CG2 . ILE A 1 13  ? -18.582 -9.977  -13.497 0.41 88.29  ? 276  ILE A CG2 1 
ATOM   32   C  CD1 . ILE A 1 13  ? -16.884 -7.940  -15.268 0.41 84.87  ? 276  ILE A CD1 1 
ATOM   33   N  N   . ILE A 1 14  ? -18.535 -9.203  -10.021 0.41 87.23  ? 277  ILE A N   1 
ATOM   34   C  CA  . ILE A 1 14  ? -18.632 -10.306 -9.014  0.41 93.06  ? 277  ILE A CA  1 
ATOM   35   C  C   . ILE A 1 14  ? -19.175 -9.786  -7.674  0.41 97.21  ? 277  ILE A C   1 
ATOM   36   O  O   . ILE A 1 14  ? -19.536 -10.635 -6.831  0.41 94.13  ? 277  ILE A O   1 
ATOM   37   C  CB  . ILE A 1 14  ? -17.267 -11.007 -8.834  0.41 95.98  ? 277  ILE A CB  1 
ATOM   38   C  CG1 . ILE A 1 14  ? -16.214 -10.095 -8.198  0.41 97.57  ? 277  ILE A CG1 1 
ATOM   39   C  CG2 . ILE A 1 14  ? -16.781 -11.587 -10.154 0.41 94.98  ? 277  ILE A CG2 1 
ATOM   40   C  CD1 . ILE A 1 14  ? -15.014 -10.837 -7.657  0.41 98.87  ? 277  ILE A CD1 1 
ATOM   41   N  N   . GLY A 1 15  ? -19.227 -8.462  -7.476  0.41 102.80 ? 278  GLY A N   1 
ATOM   42   C  CA  . GLY A 1 15  ? -19.574 -7.819  -6.190  0.41 101.87 ? 278  GLY A CA  1 
ATOM   43   C  C   . GLY A 1 15  ? -20.938 -8.246  -5.669  0.41 102.52 ? 278  GLY A C   1 
ATOM   44   O  O   . GLY A 1 15  ? -20.996 -8.793  -4.547  0.41 101.60 ? 278  GLY A O   1 
ATOM   45   N  N   . LYS A 1 16  ? -21.993 -8.011  -6.456  0.41 101.02 ? 279  LYS A N   1 
ATOM   46   C  CA  . LYS A 1 16  ? -23.413 -8.250  -6.071  0.41 100.28 ? 279  LYS A CA  1 
ATOM   47   C  C   . LYS A 1 16  ? -23.567 -9.688  -5.555  0.41 96.84  ? 279  LYS A C   1 
ATOM   48   O  O   . LYS A 1 16  ? -24.248 -9.872  -4.527  0.41 91.58  ? 279  LYS A O   1 
ATOM   49   C  CB  . LYS A 1 16  ? -24.345 -7.960  -7.255  0.41 105.38 ? 279  LYS A CB  1 
ATOM   50   C  CG  . LYS A 1 16  ? -24.423 -6.497  -7.682  0.41 108.82 ? 279  LYS A CG  1 
ATOM   51   C  CD  . LYS A 1 16  ? -25.250 -6.242  -8.936  0.41 110.69 ? 279  LYS A CD  1 
ATOM   52   C  CE  . LYS A 1 16  ? -26.748 -6.236  -8.699  0.41 112.02 ? 279  LYS A CE  1 
ATOM   53   N  NZ  . LYS A 1 16  ? -27.358 -7.566  -8.940  0.41 113.25 ? 279  LYS A NZ  1 
ATOM   54   N  N   . ARG A 1 17  ? -22.948 -10.658 -6.238  0.41 95.56  ? 280  ARG A N   1 
ATOM   55   C  CA  . ARG A 1 17  ? -22.954 -12.100 -5.861  0.41 95.05  ? 280  ARG A CA  1 
ATOM   56   C  C   . ARG A 1 17  ? -22.382 -12.268 -4.450  0.41 95.89  ? 280  ARG A C   1 
ATOM   57   O  O   . ARG A 1 17  ? -23.003 -12.986 -3.644  0.41 93.25  ? 280  ARG A O   1 
ATOM   58   C  CB  . ARG A 1 17  ? -22.145 -12.930 -6.864  0.41 94.57  ? 280  ARG A CB  1 
ATOM   59   C  CG  . ARG A 1 17  ? -22.944 -13.389 -8.075  0.41 93.54  ? 280  ARG A CG  1 
ATOM   60   C  CD  . ARG A 1 17  ? -22.081 -14.078 -9.114  0.41 88.31  ? 280  ARG A CD  1 
ATOM   61   N  NE  . ARG A 1 17  ? -21.369 -13.135 -9.965  0.41 85.80  ? 280  ARG A NE  1 
ATOM   62   C  CZ  . ARG A 1 17  ? -20.517 -13.473 -10.928 0.41 83.39  ? 280  ARG A CZ  1 
ATOM   63   N  NH1 . ARG A 1 17  ? -20.249 -14.746 -11.174 0.41 83.69  ? 280  ARG A NH1 1 
ATOM   64   N  NH2 . ARG A 1 17  ? -19.931 -12.532 -11.646 0.41 82.24  ? 280  ARG A NH2 1 
ATOM   65   N  N   . ILE A 1 18  ? -21.239 -11.634 -4.176  0.41 100.11 ? 281  ILE A N   1 
ATOM   66   C  CA  . ILE A 1 18  ? -20.549 -11.671 -2.853  0.41 105.26 ? 281  ILE A CA  1 
ATOM   67   C  C   . ILE A 1 18  ? -21.418 -10.910 -1.843  0.41 108.85 ? 281  ILE A C   1 
ATOM   68   O  O   . ILE A 1 18  ? -21.740 -11.487 -0.781  0.41 100.54 ? 281  ILE A O   1 
ATOM   69   C  CB  . ILE A 1 18  ? -19.124 -11.086 -2.959  0.41 109.91 ? 281  ILE A CB  1 
ATOM   70   C  CG1 . ILE A 1 18  ? -18.252 -11.880 -3.936  0.41 110.07 ? 281  ILE A CG1 1 
ATOM   71   C  CG2 . ILE A 1 18  ? -18.473 -10.984 -1.587  0.41 111.09 ? 281  ILE A CG2 1 
ATOM   72   C  CD1 . ILE A 1 18  ? -17.089 -11.095 -4.497  0.41 112.04 ? 281  ILE A CD1 1 
ATOM   73   N  N   . GLU A 1 19  ? -21.798 -9.674  -2.188  0.41 113.35 ? 282  GLU A N   1 
ATOM   74   C  CA  . GLU A 1 19  ? -22.590 -8.745  -1.334  0.41 118.05 ? 282  GLU A CA  1 
ATOM   75   C  C   . GLU A 1 19  ? -23.896 -9.426  -0.901  0.41 115.74 ? 282  GLU A C   1 
ATOM   76   O  O   . GLU A 1 19  ? -24.274 -9.253  0.270   0.41 119.12 ? 282  GLU A O   1 
ATOM   77   C  CB  . GLU A 1 19  ? -22.840 -7.427  -2.072  0.41 122.36 ? 282  GLU A CB  1 
ATOM   78   C  CG  . GLU A 1 19  ? -21.594 -6.558  -2.185  0.41 125.98 ? 282  GLU A CG  1 
ATOM   79   C  CD  . GLU A 1 19  ? -21.650 -5.416  -3.189  0.41 129.21 ? 282  GLU A CD  1 
ATOM   80   O  OE1 . GLU A 1 19  ? -22.288 -5.579  -4.251  0.41 132.63 ? 282  GLU A OE1 1 
ATOM   81   O  OE2 . GLU A 1 19  ? -21.040 -4.363  -2.912  0.41 129.39 ? 282  GLU A OE2 1 
ATOM   82   N  N   . LYS A 1 20  ? -24.541 -10.181 -1.798  0.41 115.34 ? 283  LYS A N   1 
ATOM   83   C  CA  . LYS A 1 20  ? -25.805 -10.920 -1.518  0.41 117.46 ? 283  LYS A CA  1 
ATOM   84   C  C   . LYS A 1 20  ? -25.540 -12.045 -0.510  0.41 118.71 ? 283  LYS A C   1 
ATOM   85   O  O   . LYS A 1 20  ? -26.414 -12.274 0.349   0.41 119.59 ? 283  LYS A O   1 
ATOM   86   C  CB  . LYS A 1 20  ? -26.407 -11.502 -2.801  0.41 120.45 ? 283  LYS A CB  1 
ATOM   87   C  CG  . LYS A 1 20  ? -27.634 -12.385 -2.595  0.41 121.04 ? 283  LYS A CG  1 
ATOM   88   C  CD  . LYS A 1 20  ? -28.347 -12.752 -3.880  0.41 123.03 ? 283  LYS A CD  1 
ATOM   89   C  CE  . LYS A 1 20  ? -29.628 -13.527 -3.652  0.41 122.43 ? 283  LYS A CE  1 
ATOM   90   N  NZ  . LYS A 1 20  ? -29.377 -14.828 -2.988  0.41 123.78 ? 283  LYS A NZ  1 
ATOM   91   N  N   . ILE A 1 21  ? -24.402 -12.736 -0.638  0.41 121.22 ? 284  ILE A N   1 
ATOM   92   C  CA  . ILE A 1 21  ? -23.982 -13.850 0.267   0.41 123.87 ? 284  ILE A CA  1 
ATOM   93   C  C   . ILE A 1 21  ? -23.616 -13.262 1.636   0.41 123.57 ? 284  ILE A C   1 
ATOM   94   O  O   . ILE A 1 21  ? -23.988 -13.875 2.656   0.41 123.07 ? 284  ILE A O   1 
ATOM   95   C  CB  . ILE A 1 21  ? -22.824 -14.664 -0.351  0.41 124.82 ? 284  ILE A CB  1 
ATOM   96   C  CG1 . ILE A 1 21  ? -23.287 -15.459 -1.575  0.41 126.05 ? 284  ILE A CG1 1 
ATOM   97   C  CG2 . ILE A 1 21  ? -22.172 -15.568 0.688   0.41 123.31 ? 284  ILE A CG2 1 
ATOM   98   C  CD1 . ILE A 1 21  ? -22.159 -15.955 -2.453  0.41 127.03 ? 284  ILE A CD1 1 
ATOM   99   N  N   . LYS A 1 22  ? -22.911 -12.125 1.649   0.41 123.41 ? 285  LYS A N   1 
ATOM   100  C  CA  . LYS A 1 22  ? -22.489 -11.404 2.882   0.41 127.15 ? 285  LYS A CA  1 
ATOM   101  C  C   . LYS A 1 22  ? -23.726 -11.040 3.714   0.41 123.87 ? 285  LYS A C   1 
ATOM   102  O  O   . LYS A 1 22  ? -23.701 -11.279 4.936   0.41 123.01 ? 285  LYS A O   1 
ATOM   103  C  CB  . LYS A 1 22  ? -21.681 -10.154 2.517   0.41 134.12 ? 285  LYS A CB  1 
ATOM   104  C  CG  . LYS A 1 22  ? -21.207 -9.320  3.700   0.41 140.14 ? 285  LYS A CG  1 
ATOM   105  C  CD  . LYS A 1 22  ? -20.414 -8.093  3.305   0.41 144.32 ? 285  LYS A CD  1 
ATOM   106  C  CE  . LYS A 1 22  ? -20.040 -7.231  4.493   0.41 147.76 ? 285  LYS A CE  1 
ATOM   107  N  NZ  . LYS A 1 22  ? -19.482 -5.925  4.069   0.41 150.83 ? 285  LYS A NZ  1 
ATOM   108  N  N   . GLN A 1 23  ? -24.757 -10.482 3.068   0.41 122.51 ? 286  GLN A N   1 
ATOM   109  C  CA  . GLN A 1 23  ? -26.036 -10.050 3.700   0.41 122.29 ? 286  GLN A CA  1 
ATOM   110  C  C   . GLN A 1 23  ? -26.702 -11.232 4.418   0.41 127.05 ? 286  GLN A C   1 
ATOM   111  O  O   . GLN A 1 23  ? -27.155 -11.040 5.560   0.41 136.79 ? 286  GLN A O   1 
ATOM   112  C  CB  . GLN A 1 23  ? -26.989 -9.475  2.649   0.41 119.01 ? 286  GLN A CB  1 
ATOM   113  C  CG  . GLN A 1 23  ? -26.612 -8.076  2.180   0.41 117.47 ? 286  GLN A CG  1 
ATOM   114  C  CD  . GLN A 1 23  ? -27.286 -7.688  0.885   0.41 116.86 ? 286  GLN A CD  1 
ATOM   115  O  OE1 . GLN A 1 23  ? -28.076 -8.441  0.316   0.41 112.61 ? 286  GLN A OE1 1 
ATOM   116  N  NE2 . GLN A 1 23  ? -26.973 -6.497  0.401   0.41 117.19 ? 286  GLN A NE2 1 
ATOM   117  N  N   . GLU A 1 24  ? -26.760 -12.400 3.771   0.41 127.83 ? 287  GLU A N   1 
ATOM   118  C  CA  . GLU A 1 24  ? -27.489 -13.604 4.262   0.41 128.76 ? 287  GLU A CA  1 
ATOM   119  C  C   . GLU A 1 24  ? -26.742 -14.233 5.448   0.41 131.54 ? 287  GLU A C   1 
ATOM   120  O  O   . GLU A 1 24  ? -27.385 -14.996 6.198   0.41 131.67 ? 287  GLU A O   1 
ATOM   121  C  CB  . GLU A 1 24  ? -27.686 -14.605 3.121   0.41 131.66 ? 287  GLU A CB  1 
ATOM   122  C  CG  . GLU A 1 24  ? -28.662 -14.118 2.062   0.41 133.10 ? 287  GLU A CG  1 
ATOM   123  C  CD  . GLU A 1 24  ? -28.639 -14.875 0.744   0.41 133.08 ? 287  GLU A CD  1 
ATOM   124  O  OE1 . GLU A 1 24  ? -28.943 -14.249 -0.293  0.41 128.51 ? 287  GLU A OE1 1 
ATOM   125  O  OE2 . GLU A 1 24  ? -28.326 -16.084 0.755   0.41 134.46 ? 287  GLU A OE2 1 
ATOM   126  N  N   . HIS A 1 25  ? -25.446 -13.936 5.607   0.41 132.37 ? 288  HIS A N   1 
ATOM   127  C  CA  . HIS A 1 25  ? -24.594 -14.396 6.738   0.41 133.36 ? 288  HIS A CA  1 
ATOM   128  C  C   . HIS A 1 25  ? -23.896 -13.189 7.382   0.41 136.12 ? 288  HIS A C   1 
ATOM   129  O  O   . HIS A 1 25  ? -22.682 -13.285 7.655   0.41 137.96 ? 288  HIS A O   1 
ATOM   130  C  CB  . HIS A 1 25  ? -23.598 -15.461 6.256   0.41 130.50 ? 288  HIS A CB  1 
ATOM   131  C  CG  . HIS A 1 25  ? -24.228 -16.578 5.494   0.41 127.84 ? 288  HIS A CG  1 
ATOM   132  N  ND1 . HIS A 1 25  ? -25.003 -17.545 6.105   0.41 130.56 ? 288  HIS A ND1 1 
ATOM   133  C  CD2 . HIS A 1 25  ? -24.198 -16.890 4.181   0.41 125.99 ? 288  HIS A CD2 1 
ATOM   134  C  CE1 . HIS A 1 25  ? -25.427 -18.403 5.199   0.41 128.81 ? 288  HIS A CE1 1 
ATOM   135  N  NE2 . HIS A 1 25  ? -24.946 -18.023 4.010   0.41 126.23 ? 288  HIS A NE2 1 
ATOM   136  N  N   . GLU A 1 26  ? -24.648 -12.108 7.627   0.41 137.46 ? 289  GLU A N   1 
ATOM   137  C  CA  . GLU A 1 26  ? -24.142 -10.815 8.171   0.41 138.60 ? 289  GLU A CA  1 
ATOM   138  C  C   . GLU A 1 26  ? -23.679 -11.003 9.623   0.41 138.24 ? 289  GLU A C   1 
ATOM   139  O  O   . GLU A 1 26  ? -22.775 -10.256 10.051  0.41 137.78 ? 289  GLU A O   1 
ATOM   140  C  CB  . GLU A 1 26  ? -25.227 -9.737  8.085   0.41 136.63 ? 289  GLU A CB  1 
ATOM   141  C  CG  . GLU A 1 26  ? -24.703 -8.315  8.222   0.41 135.16 ? 289  GLU A CG  1 
ATOM   142  C  CD  . GLU A 1 26  ? -24.222 -7.673  6.930   0.41 133.77 ? 289  GLU A CD  1 
ATOM   143  O  OE1 . GLU A 1 26  ? -23.017 -7.363  6.840   0.41 133.32 ? 289  GLU A OE1 1 
ATOM   144  O  OE2 . GLU A 1 26  ? -25.056 -7.465  6.023   0.41 127.22 ? 289  GLU A OE2 1 
ATOM   145  N  N   . THR A 1 27  ? -24.269 -11.964 10.344  0.41 136.70 ? 290  THR A N   1 
ATOM   146  C  CA  . THR A 1 27  ? -24.015 -12.230 11.787  0.41 137.73 ? 290  THR A CA  1 
ATOM   147  C  C   . THR A 1 27  ? -22.747 -13.077 11.981  0.41 135.61 ? 290  THR A C   1 
ATOM   148  O  O   . THR A 1 27  ? -22.339 -13.226 13.152  0.41 138.39 ? 290  THR A O   1 
ATOM   149  C  CB  . THR A 1 27  ? -25.223 -12.912 12.445  0.41 139.91 ? 290  THR A CB  1 
ATOM   150  O  OG1 . THR A 1 27  ? -25.442 -14.166 11.798  0.41 145.55 ? 290  THR A OG1 1 
ATOM   151  C  CG2 . THR A 1 27  ? -26.486 -12.082 12.371  0.41 139.57 ? 290  THR A CG2 1 
ATOM   152  N  N   . SER A 1 28  ? -22.150 -13.614 10.905  0.41 129.27 ? 291  SER A N   1 
ATOM   153  C  CA  . SER A 1 28  ? -20.976 -14.531 10.960  0.41 119.55 ? 291  SER A CA  1 
ATOM   154  C  C   . SER A 1 28  ? -19.913 -14.182 9.905   0.41 110.46 ? 291  SER A C   1 
ATOM   155  O  O   . SER A 1 28  ? -19.042 -15.038 9.666   0.41 108.40 ? 291  SER A O   1 
ATOM   156  C  CB  . SER A 1 28  ? -21.418 -15.969 10.811  0.41 120.33 ? 291  SER A CB  1 
ATOM   157  O  OG  . SER A 1 28  ? -22.408 -16.305 11.772  0.41 119.36 ? 291  SER A OG  1 
ATOM   158  N  N   . TRP A 1 29  ? -19.946 -12.979 9.319   0.41 104.28 ? 292  TRP A N   1 
ATOM   159  C  CA  . TRP A 1 29  ? -19.019 -12.564 8.228   0.41 101.87 ? 292  TRP A CA  1 
ATOM   160  C  C   . TRP A 1 29  ? -17.701 -12.058 8.825   0.41 98.58  ? 292  TRP A C   1 
ATOM   161  O  O   . TRP A 1 29  ? -17.688 -10.927 9.353   0.41 101.13 ? 292  TRP A O   1 
ATOM   162  C  CB  . TRP A 1 29  ? -19.667 -11.507 7.324   0.41 100.17 ? 292  TRP A CB  1 
ATOM   163  C  CG  . TRP A 1 29  ? -18.939 -11.287 6.033   0.41 99.99  ? 292  TRP A CG  1 
ATOM   164  C  CD1 . TRP A 1 29  ? -18.130 -10.235 5.709   0.41 100.93 ? 292  TRP A CD1 1 
ATOM   165  C  CD2 . TRP A 1 29  ? -18.956 -12.147 4.879   0.41 96.26  ? 292  TRP A CD2 1 
ATOM   166  N  NE1 . TRP A 1 29  ? -17.647 -10.378 4.436   0.41 99.03  ? 292  TRP A NE1 1 
ATOM   167  C  CE2 . TRP A 1 29  ? -18.136 -11.542 3.902   0.41 97.25  ? 292  TRP A CE2 1 
ATOM   168  C  CE3 . TRP A 1 29  ? -19.583 -13.361 4.577   0.41 95.48  ? 292  TRP A CE3 1 
ATOM   169  C  CZ2 . TRP A 1 29  ? -17.932 -12.114 2.647   0.41 95.57  ? 292  TRP A CZ2 1 
ATOM   170  C  CZ3 . TRP A 1 29  ? -19.378 -13.926 3.338   0.41 93.44  ? 292  TRP A CZ3 1 
ATOM   171  C  CH2 . TRP A 1 29  ? -18.564 -13.309 2.388   0.41 93.76  ? 292  TRP A CH2 1 
ATOM   172  N  N   . HIS A 1 30  ? -16.635 -12.860 8.722   0.41 93.43  ? 293  HIS A N   1 
ATOM   173  C  CA  . HIS A 1 30  ? -15.284 -12.558 9.270   0.41 91.53  ? 293  HIS A CA  1 
ATOM   174  C  C   . HIS A 1 30  ? -14.221 -12.707 8.175   0.41 89.83  ? 293  HIS A C   1 
ATOM   175  O  O   . HIS A 1 30  ? -14.196 -13.760 7.515   0.41 88.94  ? 293  HIS A O   1 
ATOM   176  C  CB  . HIS A 1 30  ? -14.989 -13.443 10.491  0.41 87.59  ? 293  HIS A CB  1 
ATOM   177  C  CG  . HIS A 1 30  ? -14.903 -14.905 10.198  0.41 83.47  ? 293  HIS A CG  1 
ATOM   178  N  ND1 . HIS A 1 30  ? -16.026 -15.700 10.064  0.41 80.72  ? 293  HIS A ND1 1 
ATOM   179  C  CD2 . HIS A 1 30  ? -13.839 -15.722 10.039  0.41 81.34  ? 293  HIS A CD2 1 
ATOM   180  C  CE1 . HIS A 1 30  ? -15.656 -16.942 9.827   0.41 78.59  ? 293  HIS A CE1 1 
ATOM   181  N  NE2 . HIS A 1 30  ? -14.319 -16.982 9.806   0.41 79.34  ? 293  HIS A NE2 1 
ATOM   182  N  N   . TYR A 1 31  ? -13.387 -11.676 7.998   0.41 89.54  ? 294  TYR A N   1 
ATOM   183  C  CA  . TYR A 1 31  ? -12.191 -11.672 7.114   0.41 88.81  ? 294  TYR A CA  1 
ATOM   184  C  C   . TYR A 1 31  ? -11.076 -12.460 7.811   0.41 89.72  ? 294  TYR A C   1 
ATOM   185  O  O   . TYR A 1 31  ? -10.379 -11.882 8.665   0.41 91.36  ? 294  TYR A O   1 
ATOM   186  C  CB  . TYR A 1 31  ? -11.774 -10.231 6.796   0.41 88.56  ? 294  TYR A CB  1 
ATOM   187  C  CG  . TYR A 1 31  ? -10.781 -10.071 5.670   0.41 94.20  ? 294  TYR A CG  1 
ATOM   188  C  CD1 . TYR A 1 31  ? -9.437  -10.371 5.843   0.41 96.82  ? 294  TYR A CD1 1 
ATOM   189  C  CD2 . TYR A 1 31  ? -11.178 -9.591  4.431   0.41 93.70  ? 294  TYR A CD2 1 
ATOM   190  C  CE1 . TYR A 1 31  ? -8.521  -10.214 4.813   0.41 96.46  ? 294  TYR A CE1 1 
ATOM   191  C  CE2 . TYR A 1 31  ? -10.276 -9.429  3.392   0.41 91.84  ? 294  TYR A CE2 1 
ATOM   192  C  CZ  . TYR A 1 31  ? -8.942  -9.741  3.583   0.41 92.01  ? 294  TYR A CZ  1 
ATOM   193  O  OH  . TYR A 1 31  ? -8.051  -9.586  2.561   0.41 90.70  ? 294  TYR A OH  1 
ATOM   194  N  N   . ASP A 1 32  ? -10.930 -13.745 7.472   0.41 88.37  ? 295  ASP A N   1 
ATOM   195  C  CA  . ASP A 1 32  ? -9.901  -14.658 8.044   0.41 89.81  ? 295  ASP A CA  1 
ATOM   196  C  C   . ASP A 1 32  ? -8.523  -14.249 7.504   0.41 93.14  ? 295  ASP A C   1 
ATOM   197  O  O   . ASP A 1 32  ? -8.313  -14.340 6.276   0.41 92.96  ? 295  ASP A O   1 
ATOM   198  C  CB  . ASP A 1 32  ? -10.230 -16.124 7.742   0.41 85.05  ? 295  ASP A CB  1 
ATOM   199  C  CG  . ASP A 1 32  ? -9.544  -17.118 8.663   0.41 82.98  ? 295  ASP A CG  1 
ATOM   200  O  OD1 . ASP A 1 32  ? -8.375  -16.879 9.021   0.41 84.15  ? 295  ASP A OD1 1 
ATOM   201  O  OD2 . ASP A 1 32  ? -10.190 -18.123 9.015   0.41 83.26  ? 295  ASP A OD2 1 
ATOM   202  N  N   . GLN A 1 33  ? -7.624  -13.813 8.394   0.41 95.33  ? 296  GLN A N   1 
ATOM   203  C  CA  . GLN A 1 33  ? -6.272  -13.295 8.046   0.41 96.16  ? 296  GLN A CA  1 
ATOM   204  C  C   . GLN A 1 33  ? -5.314  -14.464 7.785   0.41 93.30  ? 296  GLN A C   1 
ATOM   205  O  O   . GLN A 1 33  ? -4.245  -14.213 7.191   0.41 92.60  ? 296  GLN A O   1 
ATOM   206  C  CB  . GLN A 1 33  ? -5.728  -12.402 9.165   0.41 98.11  ? 296  GLN A CB  1 
ATOM   207  C  CG  . GLN A 1 33  ? -6.547  -11.139 9.403   0.41 99.03  ? 296  GLN A CG  1 
ATOM   208  C  CD  . GLN A 1 33  ? -6.399  -10.115 8.303   0.41 100.44 ? 296  GLN A CD  1 
ATOM   209  O  OE1 . GLN A 1 33  ? -5.657  -10.301 7.340   0.41 104.10 ? 296  GLN A OE1 1 
ATOM   210  N  NE2 . GLN A 1 33  ? -7.113  -9.009  8.440   0.41 101.75 ? 296  GLN A NE2 1 
ATOM   211  N  N   . ASP A 1 34  ? -5.681  -15.679 8.213   0.41 89.33  ? 297  ASP A N   1 
ATOM   212  C  CA  . ASP A 1 34  ? -4.862  -16.914 8.074   0.41 89.99  ? 297  ASP A CA  1 
ATOM   213  C  C   . ASP A 1 34  ? -5.412  -17.773 6.924   0.41 90.55  ? 297  ASP A C   1 
ATOM   214  O  O   . ASP A 1 34  ? -5.356  -19.017 7.044   0.41 92.10  ? 297  ASP A O   1 
ATOM   215  C  CB  . ASP A 1 34  ? -4.831  -17.693 9.395   0.41 90.98  ? 297  ASP A CB  1 
ATOM   216  C  CG  . ASP A 1 34  ? -4.375  -16.885 10.603  0.41 92.13  ? 297  ASP A CG  1 
ATOM   217  O  OD1 . ASP A 1 34  ? -3.750  -15.816 10.409  0.41 86.36  ? 297  ASP A OD1 1 
ATOM   218  O  OD2 . ASP A 1 34  ? -4.649  -17.331 11.737  0.41 91.07  ? 297  ASP A OD2 1 
ATOM   219  N  N   . HIS A 1 35  ? -5.904  -17.143 5.846   0.41 88.17  ? 298  HIS A N   1 
ATOM   220  C  CA  . HIS A 1 35  ? -6.550  -17.824 4.688   0.41 81.60  ? 298  HIS A CA  1 
ATOM   221  C  C   . HIS A 1 35  ? -5.470  -18.458 3.812   0.41 78.71  ? 298  HIS A C   1 
ATOM   222  O  O   . HIS A 1 35  ? -4.443  -17.837 3.551   0.41 76.53  ? 298  HIS A O   1 
ATOM   223  C  CB  . HIS A 1 35  ? -7.490  -16.870 3.925   0.41 76.11  ? 298  HIS A CB  1 
ATOM   224  C  CG  . HIS A 1 35  ? -6.824  -15.815 3.100   0.41 74.67  ? 298  HIS A CG  1 
ATOM   225  N  ND1 . HIS A 1 35  ? -6.835  -14.478 3.459   0.41 76.37  ? 298  HIS A ND1 1 
ATOM   226  C  CD2 . HIS A 1 35  ? -6.177  -15.875 1.914   0.41 73.17  ? 298  HIS A CD2 1 
ATOM   227  C  CE1 . HIS A 1 35  ? -6.201  -13.769 2.545   0.41 72.79  ? 298  HIS A CE1 1 
ATOM   228  N  NE2 . HIS A 1 35  ? -5.786  -14.602 1.588   0.41 72.74  ? 298  HIS A NE2 1 
ATOM   229  N  N   . PRO A 1 36  ? -5.659  -19.714 3.341   0.41 77.80  ? 299  PRO A N   1 
ATOM   230  C  CA  . PRO A 1 36  ? -4.613  -20.416 2.593   0.41 78.88  ? 299  PRO A CA  1 
ATOM   231  C  C   . PRO A 1 36  ? -4.407  -20.008 1.123   0.41 81.12  ? 299  PRO A C   1 
ATOM   232  O  O   . PRO A 1 36  ? -3.455  -20.487 0.534   0.41 83.25  ? 299  PRO A O   1 
ATOM   233  C  CB  . PRO A 1 36  ? -5.091  -21.875 2.645   0.41 78.52  ? 299  PRO A CB  1 
ATOM   234  C  CG  . PRO A 1 36  ? -6.601  -21.772 2.699   0.41 77.98  ? 299  PRO A CG  1 
ATOM   235  C  CD  . PRO A 1 36  ? -6.870  -20.533 3.526   0.41 77.39  ? 299  PRO A CD  1 
ATOM   236  N  N   . TYR A 1 37  ? -5.278  -19.162 0.561   1.00 82.13  ? 300  TYR A N   1 
ATOM   237  C  CA  . TYR A 1 37  ? -5.263  -18.832 -0.896  1.00 78.12  ? 300  TYR A CA  1 
ATOM   238  C  C   . TYR A 1 37  ? -4.077  -17.931 -1.231  1.00 72.48  ? 300  TYR A C   1 
ATOM   239  O  O   . TYR A 1 37  ? -3.788  -16.993 -0.480  1.00 78.66  ? 300  TYR A O   1 
ATOM   240  C  CB  . TYR A 1 37  ? -6.611  -18.266 -1.368  1.00 78.55  ? 300  TYR A CB  1 
ATOM   241  C  CG  . TYR A 1 37  ? -7.766  -19.099 -0.876  1.00 65.76  ? 300  TYR A CG  1 
ATOM   242  C  CD1 . TYR A 1 37  ? -8.054  -20.333 -1.424  1.00 70.90  ? 300  TYR A CD1 1 
ATOM   243  C  CD2 . TYR A 1 37  ? -8.479  -18.713 0.237   1.00 66.94  ? 300  TYR A CD2 1 
ATOM   244  C  CE1 . TYR A 1 37  ? -9.063  -21.137 -0.913  1.00 67.52  ? 300  TYR A CE1 1 
ATOM   245  C  CE2 . TYR A 1 37  ? -9.472  -19.508 0.775   1.00 62.30  ? 300  TYR A CE2 1 
ATOM   246  C  CZ  . TYR A 1 37  ? -9.786  -20.708 0.182   1.00 57.68  ? 300  TYR A CZ  1 
ATOM   247  O  OH  . TYR A 1 37  ? -10.762 -21.484 0.706   1.00 66.37  ? 300  TYR A OH  1 
ATOM   248  N  N   . LYS A 1 38  ? -3.417  -18.248 -2.346  1.00 71.34  ? 301  LYS A N   1 
ATOM   249  C  CA  . LYS A 1 38  ? -2.388  -17.403 -2.994  1.00 73.01  ? 301  LYS A CA  1 
ATOM   250  C  C   . LYS A 1 38  ? -2.852  -16.916 -4.373  1.00 73.31  ? 301  LYS A C   1 
ATOM   251  O  O   . LYS A 1 38  ? -2.693  -15.731 -4.652  1.00 70.69  ? 301  LYS A O   1 
ATOM   252  C  CB  . LYS A 1 38  ? -1.070  -18.165 -3.146  1.00 79.69  ? 301  LYS A CB  1 
ATOM   253  C  CG  . LYS A 1 38  ? 0.132   -17.277 -3.475  1.00 93.81  ? 301  LYS A CG  1 
ATOM   254  C  CD  . LYS A 1 38  ? 0.346   -16.104 -2.506  1.00 97.96  ? 301  LYS A CD  1 
ATOM   255  C  CE  . LYS A 1 38  ? 1.229   -15.006 -3.070  1.00 109.53 ? 301  LYS A CE  1 
ATOM   256  N  NZ  . LYS A 1 38  ? 2.673   -15.312 -2.912  1.00 112.14 ? 301  LYS A NZ  1 
ATOM   257  N  N   . THR A 1 39  ? -3.373  -17.799 -5.230  1.00 77.20  ? 302  THR A N   1 
ATOM   258  C  CA  . THR A 1 39  ? -3.696  -17.471 -6.649  1.00 71.91  ? 302  THR A CA  1 
ATOM   259  C  C   . THR A 1 39  ? -5.193  -17.158 -6.822  1.00 67.26  ? 302  THR A C   1 
ATOM   260  O  O   . THR A 1 39  ? -5.537  -16.533 -7.820  1.00 67.15  ? 302  THR A O   1 
ATOM   261  C  CB  . THR A 1 39  ? -3.265  -18.625 -7.547  1.00 69.61  ? 302  THR A CB  1 
ATOM   262  O  OG1 . THR A 1 39  ? -4.204  -19.660 -7.267  1.00 69.86  ? 302  THR A OG1 1 
ATOM   263  C  CG2 . THR A 1 39  ? -1.849  -19.080 -7.273  1.00 73.74  ? 302  THR A CG2 1 
ATOM   264  N  N   . TRP A 1 40  ? -6.042  -17.644 -5.920  1.00 62.44  ? 303  TRP A N   1 
ATOM   265  C  CA  . TRP A 1 40  ? -7.455  -17.214 -5.772  1.00 62.30  ? 303  TRP A CA  1 
ATOM   266  C  C   . TRP A 1 40  ? -7.526  -15.915 -4.967  1.00 66.69  ? 303  TRP A C   1 
ATOM   267  O  O   . TRP A 1 40  ? -6.817  -15.806 -3.951  1.00 69.36  ? 303  TRP A O   1 
ATOM   268  C  CB  . TRP A 1 40  ? -8.231  -18.289 -5.020  1.00 65.80  ? 303  TRP A CB  1 
ATOM   269  C  CG  . TRP A 1 40  ? -8.467  -19.535 -5.797  1.00 65.71  ? 303  TRP A CG  1 
ATOM   270  C  CD1 . TRP A 1 40  ? -7.606  -20.565 -5.986  1.00 68.43  ? 303  TRP A CD1 1 
ATOM   271  C  CD2 . TRP A 1 40  ? -9.673  -19.881 -6.485  1.00 70.49  ? 303  TRP A CD2 1 
ATOM   272  N  NE1 . TRP A 1 40  ? -8.200  -21.532 -6.737  1.00 73.64  ? 303  TRP A NE1 1 
ATOM   273  C  CE2 . TRP A 1 40  ? -9.470  -21.146 -7.064  1.00 74.45  ? 303  TRP A CE2 1 
ATOM   274  C  CE3 . TRP A 1 40  ? -10.902 -19.247 -6.660  1.00 66.74  ? 303  TRP A CE3 1 
ATOM   275  C  CZ2 . TRP A 1 40  ? -10.459 -21.790 -7.805  1.00 72.25  ? 303  TRP A CZ2 1 
ATOM   276  C  CZ3 . TRP A 1 40  ? -11.873 -19.879 -7.397  1.00 71.29  ? 303  TRP A CZ3 1 
ATOM   277  C  CH2 . TRP A 1 40  ? -11.657 -21.134 -7.956  1.00 69.08  ? 303  TRP A CH2 1 
ATOM   278  N  N   . ALA A 1 41  ? -8.487  -15.052 -5.308  0.41 64.46  ? 304  ALA A N   1 
ATOM   279  C  CA  . ALA A 1 41  ? -8.724  -13.825 -4.514  0.41 63.67  ? 304  ALA A CA  1 
ATOM   280  C  C   . ALA A 1 41  ? -9.723  -14.153 -3.403  0.41 62.06  ? 304  ALA A C   1 
ATOM   281  O  O   . ALA A 1 41  ? -10.817 -14.648 -3.719  0.41 59.92  ? 304  ALA A O   1 
ATOM   282  C  CB  . ALA A 1 41  ? -9.251  -12.726 -5.395  0.41 63.13  ? 304  ALA A CB  1 
ATOM   283  N  N   . TYR A 1 42  ? -9.344  -13.903 -2.150  0.41 63.31  ? 305  TYR A N   1 
ATOM   284  C  CA  . TYR A 1 42  ? -10.242 -14.173 -1.000  0.41 61.98  ? 305  TYR A CA  1 
ATOM   285  C  C   . TYR A 1 42  ? -11.124 -12.943 -0.800  0.41 61.12  ? 305  TYR A C   1 
ATOM   286  O  O   . TYR A 1 42  ? -10.695 -11.836 -1.170  0.41 61.31  ? 305  TYR A O   1 
ATOM   287  C  CB  . TYR A 1 42  ? -9.409  -14.528 0.235   0.41 60.86  ? 305  TYR A CB  1 
ATOM   288  C  CG  . TYR A 1 42  ? -10.131 -14.543 1.557   0.41 58.99  ? 305  TYR A CG  1 
ATOM   289  C  CD1 . TYR A 1 42  ? -10.890 -15.633 1.948   0.41 56.54  ? 305  TYR A CD1 1 
ATOM   290  C  CD2 . TYR A 1 42  ? -10.018 -13.483 2.440   0.41 56.77  ? 305  TYR A CD2 1 
ATOM   291  C  CE1 . TYR A 1 42  ? -11.538 -15.658 3.171   0.41 56.15  ? 305  TYR A CE1 1 
ATOM   292  C  CE2 . TYR A 1 42  ? -10.660 -13.491 3.667   0.41 55.72  ? 305  TYR A CE2 1 
ATOM   293  C  CZ  . TYR A 1 42  ? -11.424 -14.584 4.033   0.41 54.34  ? 305  TYR A CZ  1 
ATOM   294  O  OH  . TYR A 1 42  ? -12.060 -14.598 5.240   0.41 54.49  ? 305  TYR A OH  1 
ATOM   295  N  N   . HIS A 1 43  ? -12.327 -13.144 -0.268  0.41 63.14  ? 306  HIS A N   1 
ATOM   296  C  CA  . HIS A 1 43  ? -13.266 -12.012 -0.063  0.41 63.51  ? 306  HIS A CA  1 
ATOM   297  C  C   . HIS A 1 43  ? -13.771 -12.036 1.379   0.41 61.91  ? 306  HIS A C   1 
ATOM   298  O  O   . HIS A 1 43  ? -13.822 -10.963 2.002   0.41 63.32  ? 306  HIS A O   1 
ATOM   299  C  CB  . HIS A 1 43  ? -14.399 -12.070 -1.094  0.41 63.55  ? 306  HIS A CB  1 
ATOM   300  C  CG  . HIS A 1 43  ? -13.925 -11.955 -2.502  0.41 59.17  ? 306  HIS A CG  1 
ATOM   301  N  ND1 . HIS A 1 43  ? -13.613 -10.741 -3.077  0.41 59.42  ? 306  HIS A ND1 1 
ATOM   302  C  CD2 . HIS A 1 43  ? -13.705 -12.892 -3.449  0.41 57.50  ? 306  HIS A CD2 1 
ATOM   303  C  CE1 . HIS A 1 43  ? -13.223 -10.933 -4.320  0.41 57.33  ? 306  HIS A CE1 1 
ATOM   304  N  NE2 . HIS A 1 43  ? -13.271 -12.244 -4.572  0.41 58.29  ? 306  HIS A NE2 1 
ATOM   305  N  N   . GLY A 1 44  ? -14.124 -13.220 1.876   0.41 61.89  ? 307  GLY A N   1 
ATOM   306  C  CA  . GLY A 1 44  ? -14.651 -13.325 3.246   0.41 63.40  ? 307  GLY A CA  1 
ATOM   307  C  C   . GLY A 1 44  ? -14.978 -14.749 3.638   0.41 66.00  ? 307  GLY A C   1 
ATOM   308  O  O   . GLY A 1 44  ? -14.896 -15.637 2.771   0.41 63.73  ? 307  GLY A O   1 
ATOM   309  N  N   . SER A 1 45  ? -15.345 -14.950 4.902   0.41 70.48  ? 308  SER A N   1 
ATOM   310  C  CA  . SER A 1 45  ? -15.669 -16.302 5.423   0.41 75.13  ? 308  SER A CA  1 
ATOM   311  C  C   . SER A 1 45  ? -16.874 -16.205 6.364   0.41 81.08  ? 308  SER A C   1 
ATOM   312  O  O   . SER A 1 45  ? -16.989 -15.171 7.054   0.41 83.62  ? 308  SER A O   1 
ATOM   313  C  CB  . SER A 1 45  ? -14.473 -16.914 6.116   0.41 75.30  ? 308  SER A CB  1 
ATOM   314  O  OG  . SER A 1 45  ? -13.296 -16.759 5.333   0.41 67.70  ? 308  SER A OG  1 
ATOM   315  N  N   . TYR A 1 46  ? -17.730 -17.234 6.378   0.41 87.65  ? 309  TYR A N   1 
ATOM   316  C  CA  . TYR A 1 46  ? -18.954 -17.320 7.221   0.41 93.33  ? 309  TYR A CA  1 
ATOM   317  C  C   . TYR A 1 46  ? -19.118 -18.746 7.770   0.41 99.87  ? 309  TYR A C   1 
ATOM   318  O  O   . TYR A 1 46  ? -18.705 -19.719 7.103   0.41 101.14 ? 309  TYR A O   1 
ATOM   319  C  CB  . TYR A 1 46  ? -20.181 -16.828 6.440   0.41 94.04  ? 309  TYR A CB  1 
ATOM   320  C  CG  . TYR A 1 46  ? -20.738 -17.769 5.398   0.41 92.42  ? 309  TYR A CG  1 
ATOM   321  C  CD1 . TYR A 1 46  ? -21.635 -18.768 5.744   0.41 90.00  ? 309  TYR A CD1 1 
ATOM   322  C  CD2 . TYR A 1 46  ? -20.406 -17.640 4.057   0.41 91.46  ? 309  TYR A CD2 1 
ATOM   323  C  CE1 . TYR A 1 46  ? -22.164 -19.630 4.796   0.41 91.27  ? 309  TYR A CE1 1 
ATOM   324  C  CE2 . TYR A 1 46  ? -20.929 -18.491 3.095   0.41 90.68  ? 309  TYR A CE2 1 
ATOM   325  C  CZ  . TYR A 1 46  ? -21.811 -19.492 3.465   0.41 91.29  ? 309  TYR A CZ  1 
ATOM   326  O  OH  . TYR A 1 46  ? -22.338 -20.341 2.533   0.41 87.17  ? 309  TYR A OH  1 
ATOM   327  N  N   . GLU A 1 47  ? -19.712 -18.849 8.964   0.41 105.82 ? 310  GLU A N   1 
ATOM   328  C  CA  . GLU A 1 47  ? -19.910 -20.111 9.729   0.41 113.26 ? 310  GLU A CA  1 
ATOM   329  C  C   . GLU A 1 47  ? -20.814 -21.058 8.930   0.41 113.56 ? 310  GLU A C   1 
ATOM   330  O  O   . GLU A 1 47  ? -21.825 -20.581 8.381   0.41 116.93 ? 310  GLU A O   1 
ATOM   331  C  CB  . GLU A 1 47  ? -20.505 -19.787 11.104  0.41 119.43 ? 310  GLU A CB  1 
ATOM   332  C  CG  . GLU A 1 47  ? -20.651 -20.992 12.019  0.41 124.27 ? 310  GLU A CG  1 
ATOM   333  C  CD  . GLU A 1 47  ? -20.998 -20.656 13.461  0.41 129.31 ? 310  GLU A CD  1 
ATOM   334  O  OE1 . GLU A 1 47  ? -20.443 -19.668 13.991  0.41 128.71 ? 310  GLU A OE1 1 
ATOM   335  O  OE2 . GLU A 1 47  ? -21.825 -21.381 14.052  0.41 135.04 ? 310  GLU A OE2 1 
ATOM   336  N  N   . THR A 1 48  ? -20.457 -22.346 8.875   0.41 116.09 ? 311  THR A N   1 
ATOM   337  C  CA  . THR A 1 48  ? -21.224 -23.420 8.184   0.41 117.28 ? 311  THR A CA  1 
ATOM   338  C  C   . THR A 1 48  ? -20.934 -24.770 8.851   0.41 118.69 ? 311  THR A C   1 
ATOM   339  O  O   . THR A 1 48  ? -19.784 -24.945 9.304   0.41 124.90 ? 311  THR A O   1 
ATOM   340  C  CB  . THR A 1 48  ? -20.913 -23.439 6.681   0.41 120.22 ? 311  THR A CB  1 
ATOM   341  O  OG1 . THR A 1 48  ? -21.619 -24.539 6.106   0.41 123.59 ? 311  THR A OG1 1 
ATOM   342  C  CG2 . THR A 1 48  ? -19.436 -23.556 6.371   0.41 119.65 ? 311  THR A CG2 1 
ATOM   343  N  N   . ALA A 1 54  ? -20.050 -39.054 1.931   0.41 80.56  ? 317  ALA A N   1 
ATOM   344  C  CA  . ALA A 1 54  ? -20.204 -39.347 0.483   0.41 81.46  ? 317  ALA A CA  1 
ATOM   345  C  C   . ALA A 1 54  ? -19.063 -40.261 0.010   0.41 80.09  ? 317  ALA A C   1 
ATOM   346  O  O   . ALA A 1 54  ? -18.191 -39.782 -0.747  0.41 84.90  ? 317  ALA A O   1 
ATOM   347  C  CB  . ALA A 1 54  ? -20.252 -38.056 -0.305  0.41 78.66  ? 317  ALA A CB  1 
ATOM   348  N  N   . SER A 1 55  ? -19.082 -41.532 0.433   0.41 74.63  ? 318  SER A N   1 
ATOM   349  C  CA  . SER A 1 55  ? -18.058 -42.563 0.109   0.41 65.94  ? 318  SER A CA  1 
ATOM   350  C  C   . SER A 1 55  ? -18.626 -43.576 -0.898  0.41 57.33  ? 318  SER A C   1 
ATOM   351  O  O   . SER A 1 55  ? -19.850 -43.581 -1.115  0.41 53.04  ? 318  SER A O   1 
ATOM   352  C  CB  . SER A 1 55  ? -17.559 -43.246 1.362   0.41 65.19  ? 318  SER A CB  1 
ATOM   353  O  OG  . SER A 1 55  ? -18.323 -44.411 1.656   0.41 63.52  ? 318  SER A OG  1 
ATOM   354  N  N   . SER A 1 56  ? -17.755 -44.391 -1.498  0.41 50.92  ? 319  SER A N   1 
ATOM   355  C  CA  . SER A 1 56  ? -18.132 -45.522 -2.382  0.41 48.00  ? 319  SER A CA  1 
ATOM   356  C  C   . SER A 1 56  ? -18.793 -46.614 -1.532  0.41 44.34  ? 319  SER A C   1 
ATOM   357  O  O   . SER A 1 56  ? -18.259 -46.919 -0.450  0.41 41.23  ? 319  SER A O   1 
ATOM   358  C  CB  . SER A 1 56  ? -16.942 -46.061 -3.153  0.41 50.81  ? 319  SER A CB  1 
ATOM   359  O  OG  . SER A 1 56  ? -15.828 -46.294 -2.303  0.41 51.75  ? 319  SER A OG  1 
ATOM   360  N  N   . MET A 1 57  ? -19.907 -47.173 -2.019  0.41 39.25  ? 320  MET A N   1 
ATOM   361  C  CA  . MET A 1 57  ? -20.664 -48.282 -1.379  0.41 35.37  ? 320  MET A CA  1 
ATOM   362  C  C   . MET A 1 57  ? -20.580 -49.532 -2.266  0.41 31.63  ? 320  MET A C   1 
ATOM   363  O  O   . MET A 1 57  ? -20.736 -49.403 -3.491  0.41 30.45  ? 320  MET A O   1 
ATOM   364  C  CB  . MET A 1 57  ? -22.123 -47.868 -1.204  0.41 37.06  ? 320  MET A CB  1 
ATOM   365  C  CG  . MET A 1 57  ? -22.277 -46.436 -0.695  0.41 39.09  ? 320  MET A CG  1 
ATOM   366  S  SD  . MET A 1 57  ? -21.498 -46.225 0.924   0.41 42.30  ? 320  MET A SD  1 
ATOM   367  C  CE  . MET A 1 57  ? -22.628 -47.180 1.936   0.41 39.15  ? 320  MET A CE  1 
ATOM   368  N  N   . VAL A 1 58  ? -20.390 -50.708 -1.673  1.00 29.70  ? 321  VAL A N   1 
ATOM   369  C  CA  . VAL A 1 58  ? -20.233 -51.943 -2.474  1.00 28.21  ? 321  VAL A CA  1 
ATOM   370  C  C   . VAL A 1 58  ? -21.592 -52.434 -3.006  1.00 28.28  ? 321  VAL A C   1 
ATOM   371  O  O   . VAL A 1 58  ? -22.508 -52.402 -2.253  1.00 31.77  ? 321  VAL A O   1 
ATOM   372  C  CB  . VAL A 1 58  ? -19.459 -53.022 -1.728  1.00 29.17  ? 321  VAL A CB  1 
ATOM   373  C  CG1 . VAL A 1 58  ? -19.346 -54.310 -2.560  1.00 25.97  ? 321  VAL A CG1 1 
ATOM   374  C  CG2 . VAL A 1 58  ? -18.097 -52.474 -1.380  1.00 33.92  ? 321  VAL A CG2 1 
ATOM   375  N  N   . ASN A 1 59  ? -21.643 -52.795 -4.302  1.00 24.37  ? 322  ASN A N   1 
ATOM   376  C  CA  . ASN A 1 59  ? -22.729 -53.539 -4.957  1.00 24.24  ? 322  ASN A CA  1 
ATOM   377  C  C   . ASN A 1 59  ? -22.609 -55.028 -4.599  1.00 24.43  ? 322  ASN A C   1 
ATOM   378  O  O   . ASN A 1 59  ? -21.773 -55.793 -5.160  1.00 25.54  ? 322  ASN A O   1 
ATOM   379  C  CB  . ASN A 1 59  ? -22.755 -53.315 -6.465  1.00 25.22  ? 322  ASN A CB  1 
ATOM   380  C  CG  . ASN A 1 59  ? -23.982 -53.929 -7.095  1.00 25.13  ? 322  ASN A CG  1 
ATOM   381  O  OD1 . ASN A 1 59  ? -24.425 -55.019 -6.713  1.00 24.66  ? 322  ASN A OD1 1 
ATOM   382  N  ND2 . ASN A 1 59  ? -24.542 -53.226 -8.086  1.00 27.55  ? 322  ASN A ND2 1 
ATOM   383  N  N   . GLY A 1 60  ? -23.454 -55.433 -3.692  1.00 26.83  ? 323  GLY A N   1 
ATOM   384  C  CA  . GLY A 1 60  ? -23.508 -56.808 -3.206  1.00 25.47  ? 323  GLY A CA  1 
ATOM   385  C  C   . GLY A 1 60  ? -23.877 -57.851 -4.230  1.00 26.55  ? 323  GLY A C   1 
ATOM   386  O  O   . GLY A 1 60  ? -23.333 -58.976 -4.199  1.00 26.47  ? 323  GLY A O   1 
ATOM   387  N  N   . VAL A 1 61  ? -24.743 -57.524 -5.162  1.00 25.34  ? 324  VAL A N   1 
ATOM   388  C  CA  . VAL A 1 61  ? -25.085 -58.515 -6.196  1.00 25.07  ? 324  VAL A CA  1 
ATOM   389  C  C   . VAL A 1 61  ? -23.805 -58.815 -6.978  1.00 23.58  ? 324  VAL A C   1 
ATOM   390  O  O   . VAL A 1 61  ? -23.488 -60.014 -7.185  1.00 23.35  ? 324  VAL A O   1 
ATOM   391  C  CB  . VAL A 1 61  ? -26.274 -58.020 -7.046  1.00 23.91  ? 324  VAL A CB  1 
ATOM   392  C  CG1 . VAL A 1 61  ? -26.417 -58.810 -8.306  1.00 22.94  ? 324  VAL A CG1 1 
ATOM   393  C  CG2 . VAL A 1 61  ? -27.552 -57.990 -6.218  1.00 27.02  ? 324  VAL A CG2 1 
ATOM   394  N  N   . VAL A 1 62  ? -23.085 -57.797 -7.472  1.00 21.47  ? 325  VAL A N   1 
ATOM   395  C  CA  . VAL A 1 62  ? -21.872 -58.019 -8.307  1.00 21.66  ? 325  VAL A CA  1 
ATOM   396  C  C   . VAL A 1 62  ? -20.784 -58.693 -7.453  1.00 21.54  ? 325  VAL A C   1 
ATOM   397  O  O   . VAL A 1 62  ? -20.159 -59.650 -7.935  1.00 20.36  ? 325  VAL A O   1 
ATOM   398  C  CB  . VAL A 1 62  ? -21.373 -56.723 -8.980  1.00 22.60  ? 325  VAL A CB  1 
ATOM   399  C  CG1 . VAL A 1 62  ? -20.100 -56.928 -9.766  1.00 23.05  ? 325  VAL A CG1 1 
ATOM   400  C  CG2 . VAL A 1 62  ? -22.410 -56.095 -9.887  1.00 26.02  ? 325  VAL A CG2 1 
ATOM   401  N  N   . ARG A 1 63  ? -20.615 -58.298 -6.199  1.00 22.59  ? 326  ARG A N   1 
ATOM   402  C  CA  . ARG A 1 63  ? -19.521 -58.887 -5.395  1.00 22.65  ? 326  ARG A CA  1 
ATOM   403  C  C   . ARG A 1 63  ? -19.795 -60.375 -5.176  1.00 22.49  ? 326  ARG A C   1 
ATOM   404  O  O   . ARG A 1 63  ? -18.834 -61.199 -5.314  1.00 20.33  ? 326  ARG A O   1 
ATOM   405  C  CB  . ARG A 1 63  ? -19.232 -58.136 -4.118  1.00 22.51  ? 326  ARG A CB  1 
ATOM   406  C  CG  . ARG A 1 63  ? -18.178 -58.809 -3.231  1.00 22.98  ? 326  ARG A CG  1 
ATOM   407  C  CD  . ARG A 1 63  ? -17.482 -57.851 -2.289  1.00 19.52  ? 326  ARG A CD  1 
ATOM   408  N  NE  . ARG A 1 63  ? -18.373 -57.418 -1.246  1.00 22.31  ? 326  ARG A NE  1 
ATOM   409  C  CZ  . ARG A 1 63  ? -18.048 -56.595 -0.265  1.00 23.27  ? 326  ARG A CZ  1 
ATOM   410  N  NH1 . ARG A 1 63  ? -16.805 -56.175 -0.139  1.00 23.81  ? 326  ARG A NH1 1 
ATOM   411  N  NH2 . ARG A 1 63  ? -18.979 -56.154 0.580   1.00 24.92  ? 326  ARG A NH2 1 
ATOM   412  N  N   . LEU A 1 64  ? -21.009 -60.789 -4.830  1.00 21.31  ? 327  LEU A N   1 
ATOM   413  C  CA  . LEU A 1 64  ? -21.260 -62.234 -4.571  1.00 22.74  ? 327  LEU A CA  1 
ATOM   414  C  C   . LEU A 1 64  ? -21.003 -63.054 -5.834  1.00 19.91  ? 327  LEU A C   1 
ATOM   415  O  O   . LEU A 1 64  ? -20.724 -64.254 -5.719  1.00 24.20  ? 327  LEU A O   1 
ATOM   416  C  CB  . LEU A 1 64  ? -22.703 -62.467 -4.088  1.00 20.89  ? 327  LEU A CB  1 
ATOM   417  C  CG  . LEU A 1 64  ? -22.945 -62.138 -2.626  1.00 24.41  ? 327  LEU A CG  1 
ATOM   418  C  CD1 . LEU A 1 64  ? -24.440 -62.241 -2.260  1.00 25.11  ? 327  LEU A CD1 1 
ATOM   419  C  CD2 . LEU A 1 64  ? -22.101 -62.973 -1.684  1.00 26.89  ? 327  LEU A CD2 1 
ATOM   420  N  N   . LEU A 1 65  ? -21.133 -62.484 -7.020  1.00 21.28  ? 328  LEU A N   1 
ATOM   421  C  CA  . LEU A 1 65  ? -20.908 -63.271 -8.285  1.00 21.22  ? 328  LEU A CA  1 
ATOM   422  C  C   . LEU A 1 65  ? -19.483 -63.109 -8.849  1.00 24.06  ? 328  LEU A C   1 
ATOM   423  O  O   . LEU A 1 65  ? -19.236 -63.583 -9.977  1.00 23.23  ? 328  LEU A O   1 
ATOM   424  C  CB  . LEU A 1 65  ? -21.994 -62.841 -9.277  1.00 24.88  ? 328  LEU A CB  1 
ATOM   425  C  CG  . LEU A 1 65  ? -23.409 -63.216 -8.799  1.00 24.22  ? 328  LEU A CG  1 
ATOM   426  C  CD1 . LEU A 1 65  ? -24.526 -62.586 -9.650  1.00 24.22  ? 328  LEU A CD1 1 
ATOM   427  C  CD2 . LEU A 1 65  ? -23.547 -64.714 -8.807  1.00 26.31  ? 328  LEU A CD2 1 
ATOM   428  N  N   . THR A 1 66  ? -18.610 -62.412 -8.135  1.00 19.04  ? 329  THR A N   1 
ATOM   429  C  CA  . THR A 1 66  ? -17.196 -62.245 -8.518  1.00 23.50  ? 329  THR A CA  1 
ATOM   430  C  C   . THR A 1 66  ? -16.278 -62.656 -7.335  1.00 22.70  ? 329  THR A C   1 
ATOM   431  O  O   . THR A 1 66  ? -15.272 -61.958 -7.030  1.00 21.14  ? 329  THR A O   1 
ATOM   432  C  CB  . THR A 1 66  ? -16.956 -60.825 -9.061  1.00 21.46  ? 329  THR A CB  1 
ATOM   433  O  OG1 . THR A 1 66  ? -17.396 -59.785 -8.164  1.00 19.66  ? 329  THR A OG1 1 
ATOM   434  C  CG2 . THR A 1 66  ? -17.650 -60.655 -10.398 1.00 22.01  ? 329  THR A CG2 1 
ATOM   435  N  N   . LYS A 1 67  ? -16.521 -63.794 -6.728  1.00 20.43  ? 330  LYS A N   1 
ATOM   436  C  CA  . LYS A 1 67  ? -15.792 -64.210 -5.505  1.00 21.47  ? 330  LYS A CA  1 
ATOM   437  C  C   . LYS A 1 67  ? -14.264 -64.228 -5.713  1.00 21.33  ? 330  LYS A C   1 
ATOM   438  O  O   . LYS A 1 67  ? -13.555 -63.829 -4.794  1.00 23.79  ? 330  LYS A O   1 
ATOM   439  C  CB  . LYS A 1 67  ? -16.342 -65.533 -4.992  1.00 24.03  ? 330  LYS A CB  1 
ATOM   440  C  CG  . LYS A 1 67  ? -15.840 -65.966 -3.627  1.00 26.28  ? 330  LYS A CG  1 
ATOM   441  C  CD  . LYS A 1 67  ? -16.387 -67.316 -3.188  1.00 26.33  ? 330  LYS A CD  1 
ATOM   442  C  CE  . LYS A 1 67  ? -16.174 -67.453 -1.682  1.00 31.63  ? 330  LYS A CE  1 
ATOM   443  N  NZ  . LYS A 1 67  ? -16.402 -68.848 -1.262  1.00 35.22  ? 330  LYS A NZ  1 
ATOM   444  N  N   . PRO A 1 68  ? -13.683 -64.717 -6.813  1.00 19.04  ? 331  PRO A N   1 
ATOM   445  C  CA  . PRO A 1 68  ? -12.220 -64.865 -6.909  1.00 19.84  ? 331  PRO A CA  1 
ATOM   446  C  C   . PRO A 1 68  ? -11.524 -63.512 -6.673  1.00 22.40  ? 331  PRO A C   1 
ATOM   447  O  O   . PRO A 1 68  ? -10.389 -63.478 -6.250  1.00 22.40  ? 331  PRO A O   1 
ATOM   448  C  CB  . PRO A 1 68  ? -11.971 -65.315 -8.368  1.00 21.20  ? 331  PRO A CB  1 
ATOM   449  C  CG  . PRO A 1 68  ? -13.251 -66.104 -8.679  1.00 23.51  ? 331  PRO A CG  1 
ATOM   450  C  CD  . PRO A 1 68  ? -14.367 -65.342 -7.957  1.00 22.87  ? 331  PRO A CD  1 
ATOM   451  N  N   . TRP A 1 69  ? -12.227 -62.403 -7.002  1.00 21.46  ? 332  TRP A N   1 
ATOM   452  C  CA  . TRP A 1 69  ? -11.658 -61.046 -6.944  1.00 22.56  ? 332  TRP A CA  1 
ATOM   453  C  C   . TRP A 1 69  ? -11.681 -60.494 -5.518  1.00 23.64  ? 332  TRP A C   1 
ATOM   454  O  O   . TRP A 1 69  ? -11.091 -59.412 -5.290  1.00 23.86  ? 332  TRP A O   1 
ATOM   455  C  CB  . TRP A 1 69  ? -12.288 -60.141 -8.003  1.00 22.00  ? 332  TRP A CB  1 
ATOM   456  C  CG  . TRP A 1 69  ? -11.934 -60.548 -9.393  1.00 21.34  ? 332  TRP A CG  1 
ATOM   457  C  CD1 . TRP A 1 69  ? -10.839 -60.122 -10.091 1.00 22.56  ? 332  TRP A CD1 1 
ATOM   458  C  CD2 . TRP A 1 69  ? -12.532 -61.587 -10.193 1.00 22.10  ? 332  TRP A CD2 1 
ATOM   459  N  NE1 . TRP A 1 69  ? -10.749 -60.785 -11.278 1.00 21.95  ? 332  TRP A NE1 1 
ATOM   460  C  CE2 . TRP A 1 69  ? -11.772 -61.685 -11.367 1.00 22.05  ? 332  TRP A CE2 1 
ATOM   461  C  CE3 . TRP A 1 69  ? -13.660 -62.393 -10.070 1.00 24.71  ? 332  TRP A CE3 1 
ATOM   462  C  CZ2 . TRP A 1 69  ? -12.104 -62.544 -12.395 1.00 27.54  ? 332  TRP A CZ2 1 
ATOM   463  C  CZ3 . TRP A 1 69  ? -14.009 -63.227 -11.096 1.00 24.35  ? 332  TRP A CZ3 1 
ATOM   464  C  CH2 . TRP A 1 69  ? -13.216 -63.327 -12.238 1.00 26.81  ? 332  TRP A CH2 1 
ATOM   465  N  N   . ASP A 1 70  ? -12.301 -61.215 -4.574  0.41 23.71  ? 333  ASP A N   1 
ATOM   466  C  CA  . ASP A 1 70  ? -12.407 -60.786 -3.148  0.41 23.28  ? 333  ASP A CA  1 
ATOM   467  C  C   . ASP A 1 70  ? -11.019 -60.754 -2.482  0.41 23.39  ? 333  ASP A C   1 
ATOM   468  O  O   . ASP A 1 70  ? -10.912 -60.214 -1.346  0.41 24.08  ? 333  ASP A O   1 
ATOM   469  C  CB  . ASP A 1 70  ? -13.359 -61.701 -2.367  0.41 23.31  ? 333  ASP A CB  1 
ATOM   470  C  CG  . ASP A 1 70  ? -14.798 -61.722 -2.881  0.41 23.03  ? 333  ASP A CG  1 
ATOM   471  O  OD1 . ASP A 1 70  ? -15.172 -60.812 -3.655  0.41 23.94  ? 333  ASP A OD1 1 
ATOM   472  O  OD2 . ASP A 1 70  ? -15.532 -62.646 -2.502  0.41 23.35  ? 333  ASP A OD2 1 
ATOM   473  N  N   . ILE A 1 71  ? -10.003 -61.345 -3.123  0.41 23.98  ? 334  ILE A N   1 
ATOM   474  C  CA  . ILE A 1 71  ? -8.618  -61.482 -2.585  0.41 24.32  ? 334  ILE A CA  1 
ATOM   475  C  C   . ILE A 1 71  ? -7.629  -60.624 -3.395  0.41 26.73  ? 334  ILE A C   1 
ATOM   476  O  O   . ILE A 1 71  ? -6.419  -60.558 -2.990  0.41 23.90  ? 334  ILE A O   1 
ATOM   477  C  CB  . ILE A 1 71  ? -8.184  -62.964 -2.546  0.41 25.19  ? 334  ILE A CB  1 
ATOM   478  C  CG1 . ILE A 1 71  ? -8.140  -63.615 -3.934  0.41 25.12  ? 334  ILE A CG1 1 
ATOM   479  C  CG2 . ILE A 1 71  ? -9.059  -63.767 -1.593  0.41 24.49  ? 334  ILE A CG2 1 
ATOM   480  C  CD1 . ILE A 1 71  ? -7.314  -64.878 -3.986  0.41 25.63  ? 334  ILE A CD1 1 
ATOM   481  N  N   . ILE A 1 72  ? -8.070  -60.009 -4.498  0.41 26.11  ? 335  ILE A N   1 
ATOM   482  C  CA  . ILE A 1 72  ? -7.182  -59.260 -5.439  0.41 26.77  ? 335  ILE A CA  1 
ATOM   483  C  C   . ILE A 1 72  ? -7.101  -57.809 -4.975  0.41 27.83  ? 335  ILE A C   1 
ATOM   484  O  O   . ILE A 1 72  ? -8.104  -57.082 -5.032  0.41 29.13  ? 335  ILE A O   1 
ATOM   485  C  CB  . ILE A 1 72  ? -7.703  -59.371 -6.889  0.41 28.55  ? 335  ILE A CB  1 
ATOM   486  C  CG1 . ILE A 1 72  ? -7.774  -60.831 -7.369  0.41 29.16  ? 335  ILE A CG1 1 
ATOM   487  C  CG2 . ILE A 1 72  ? -6.905  -58.456 -7.821  0.41 26.92  ? 335  ILE A CG2 1 
ATOM   488  C  CD1 . ILE A 1 72  ? -6.819  -61.223 -8.483  0.41 28.31  ? 335  ILE A CD1 1 
ATOM   489  N  N   . PRO A 1 73  ? -5.912  -57.335 -4.526  0.41 29.88  ? 336  PRO A N   1 
ATOM   490  C  CA  . PRO A 1 73  ? -5.760  -55.978 -3.996  0.41 30.84  ? 336  PRO A CA  1 
ATOM   491  C  C   . PRO A 1 73  ? -6.366  -54.874 -4.874  0.41 32.09  ? 336  PRO A C   1 
ATOM   492  O  O   . PRO A 1 73  ? -7.196  -54.126 -4.373  0.41 32.52  ? 336  PRO A O   1 
ATOM   493  C  CB  . PRO A 1 73  ? -4.237  -55.782 -3.898  0.41 31.70  ? 336  PRO A CB  1 
ATOM   494  C  CG  . PRO A 1 73  ? -3.692  -57.183 -3.729  0.41 30.48  ? 336  PRO A CG  1 
ATOM   495  C  CD  . PRO A 1 73  ? -4.649  -58.088 -4.486  0.41 28.81  ? 336  PRO A CD  1 
ATOM   496  N  N   . MET A 1 74  ? -5.981  -54.804 -6.150  0.41 31.60  ? 337  MET A N   1 
ATOM   497  C  CA  . MET A 1 74  ? -6.390  -53.685 -7.046  0.41 31.77  ? 337  MET A CA  1 
ATOM   498  C  C   . MET A 1 74  ? -7.904  -53.489 -6.944  0.41 29.99  ? 337  MET A C   1 
ATOM   499  O  O   . MET A 1 74  ? -8.326  -52.341 -6.734  0.41 27.06  ? 337  MET A O   1 
ATOM   500  C  CB  . MET A 1 74  ? -6.007  -53.949 -8.506  0.41 33.71  ? 337  MET A CB  1 
ATOM   501  C  CG  . MET A 1 74  ? -4.514  -53.825 -8.777  0.41 39.59  ? 337  MET A CG  1 
ATOM   502  S  SD  . MET A 1 74  ? -3.888  -52.119 -8.644  0.41 43.74  ? 337  MET A SD  1 
ATOM   503  C  CE  . MET A 1 74  ? -4.841  -51.310 -9.931  0.41 43.96  ? 337  MET A CE  1 
ATOM   504  N  N   . VAL A 1 75  ? -8.668  -54.583 -7.067  0.41 27.92  ? 338  VAL A N   1 
ATOM   505  C  CA  . VAL A 1 75  ? -10.163 -54.590 -7.078  0.41 26.85  ? 338  VAL A CA  1 
ATOM   506  C  C   . VAL A 1 75  ? -10.688 -54.168 -5.700  0.41 27.73  ? 338  VAL A C   1 
ATOM   507  O  O   . VAL A 1 75  ? -11.500 -53.250 -5.647  0.41 29.98  ? 338  VAL A O   1 
ATOM   508  C  CB  . VAL A 1 75  ? -10.724 -55.967 -7.487  0.41 26.67  ? 338  VAL A CB  1 
ATOM   509  C  CG1 . VAL A 1 75  ? -12.203 -56.107 -7.141  0.41 27.59  ? 338  VAL A CG1 1 
ATOM   510  C  CG2 . VAL A 1 75  ? -10.483 -56.256 -8.961  0.41 26.96  ? 338  VAL A CG2 1 
ATOM   511  N  N   . THR A 1 76  ? -10.258 -54.835 -4.631  0.41 28.05  ? 339  THR A N   1 
ATOM   512  C  CA  . THR A 1 76  ? -10.763 -54.602 -3.254  0.41 29.22  ? 339  THR A CA  1 
ATOM   513  C  C   . THR A 1 76  ? -10.537 -53.137 -2.873  0.41 29.66  ? 339  THR A C   1 
ATOM   514  O  O   . THR A 1 76  ? -11.501 -52.481 -2.411  0.41 28.24  ? 339  THR A O   1 
ATOM   515  C  CB  . THR A 1 76  ? -10.121 -55.576 -2.257  0.41 30.93  ? 339  THR A CB  1 
ATOM   516  O  OG1 . THR A 1 76  ? -8.700  -55.482 -2.354  0.41 31.13  ? 339  THR A OG1 1 
ATOM   517  C  CG2 . THR A 1 76  ? -10.554 -57.007 -2.496  0.41 32.02  ? 339  THR A CG2 1 
ATOM   518  N  N   . GLN A 1 77  ? -9.336  -52.622 -3.143  0.41 28.51  ? 340  GLN A N   1 
ATOM   519  C  CA  . GLN A 1 77  ? -8.868  -51.313 -2.616  0.41 29.72  ? 340  GLN A CA  1 
ATOM   520  C  C   . GLN A 1 77  ? -9.563  -50.174 -3.374  0.41 28.86  ? 340  GLN A C   1 
ATOM   521  O  O   . GLN A 1 77  ? -9.570  -49.061 -2.832  0.41 29.75  ? 340  GLN A O   1 
ATOM   522  C  CB  . GLN A 1 77  ? -7.337  -51.215 -2.667  0.41 28.94  ? 340  GLN A CB  1 
ATOM   523  C  CG  . GLN A 1 77  ? -6.619  -52.477 -2.193  0.41 32.03  ? 340  GLN A CG  1 
ATOM   524  C  CD  . GLN A 1 77  ? -6.036  -52.432 -0.797  0.41 33.66  ? 340  GLN A CD  1 
ATOM   525  O  OE1 . GLN A 1 77  ? -6.600  -51.832 0.112   0.41 34.69  ? 340  GLN A OE1 1 
ATOM   526  N  NE2 . GLN A 1 77  ? -4.898  -53.095 -0.616  0.41 33.87  ? 340  GLN A NE2 1 
ATOM   527  N  N   . MET A 1 78  ? -10.140 -50.435 -4.559  1.00 27.39  ? 341  MET A N   1 
ATOM   528  C  CA  . MET A 1 78  ? -10.927 -49.411 -5.296  1.00 30.77  ? 341  MET A CA  1 
ATOM   529  C  C   . MET A 1 78  ? -12.160 -49.007 -4.502  1.00 26.01  ? 341  MET A C   1 
ATOM   530  O  O   . MET A 1 78  ? -12.571 -47.895 -4.700  1.00 26.53  ? 341  MET A O   1 
ATOM   531  C  CB  . MET A 1 78  ? -11.433 -49.806 -6.688  1.00 32.06  ? 341  MET A CB  1 
ATOM   532  C  CG  . MET A 1 78  ? -10.344 -50.196 -7.624  1.00 41.20  ? 341  MET A CG  1 
ATOM   533  S  SD  . MET A 1 78  ? -10.912 -50.501 -9.363  1.00 42.03  ? 341  MET A SD  1 
ATOM   534  C  CE  . MET A 1 78  ? -12.228 -49.292 -9.397  1.00 29.00  ? 341  MET A CE  1 
ATOM   535  N  N   . ALA A 1 79  ? -12.724 -49.844 -3.620  1.00 28.54  ? 342  ALA A N   1 
ATOM   536  C  CA  . ALA A 1 79  ? -13.982 -49.523 -2.892  1.00 31.44  ? 342  ALA A CA  1 
ATOM   537  C  C   . ALA A 1 79  ? -13.643 -48.778 -1.593  1.00 33.20  ? 342  ALA A C   1 
ATOM   538  O  O   . ALA A 1 79  ? -14.558 -48.298 -0.928  1.00 32.94  ? 342  ALA A O   1 
ATOM   539  C  CB  . ALA A 1 79  ? -14.738 -50.823 -2.634  1.00 34.42  ? 342  ALA A CB  1 
ATOM   540  N  N   . MET A 1 80  ? -12.379 -48.657 -1.225  1.00 33.20  ? 343  MET A N   1 
ATOM   541  C  CA  . MET A 1 80  ? -11.975 -48.019 0.075   1.00 40.98  ? 343  MET A CA  1 
ATOM   542  C  C   . MET A 1 80  ? -11.737 -46.495 -0.077  1.00 50.56  ? 343  MET A C   1 
ATOM   543  O  O   . MET A 1 80  ? -11.526 -46.040 -1.211  1.00 52.70  ? 343  MET A O   1 
ATOM   544  C  CB  . MET A 1 80  ? -10.691 -48.666 0.614   1.00 39.16  ? 343  MET A CB  1 
ATOM   545  C  CG  . MET A 1 80  ? -10.769 -50.185 0.749   1.00 41.99  ? 343  MET A CG  1 
ATOM   546  S  SD  . MET A 1 80  ? -12.206 -50.821 1.755   1.00 42.97  ? 343  MET A SD  1 
ATOM   547  C  CE  . MET A 1 80  ? -11.647 -50.514 3.436   1.00 42.55  ? 343  MET A CE  1 
ATOM   548  N  N   . THR A 1 81  ? -11.726 -45.744 1.035   1.00 72.29  ? 344  THR A N   1 
ATOM   549  C  CA  . THR A 1 81  ? -11.239 -44.338 1.125   1.00 73.94  ? 344  THR A CA  1 
ATOM   550  C  C   . THR A 1 81  ? -12.225 -43.409 1.830   1.00 69.30  ? 344  THR A C   1 
ATOM   551  O  O   . THR A 1 81  ? -13.453 -43.605 1.622   1.00 71.87  ? 344  THR A O   1 
ATOM   552  N  N   . GLU A 1 94  ? -4.837  -30.362 -4.834  0.41 110.19 ? 357  GLU A N   1 
ATOM   553  C  CA  . GLU A 1 94  ? -4.396  -29.012 -4.386  0.41 108.89 ? 357  GLU A CA  1 
ATOM   554  C  C   . GLU A 1 94  ? -3.800  -28.247 -5.578  0.41 112.16 ? 357  GLU A C   1 
ATOM   555  O  O   . GLU A 1 94  ? -3.023  -27.296 -5.341  0.41 116.13 ? 357  GLU A O   1 
ATOM   556  C  CB  . GLU A 1 94  ? -3.387  -29.155 -3.242  0.41 107.08 ? 357  GLU A CB  1 
ATOM   557  C  CG  . GLU A 1 94  ? -3.718  -28.310 -2.023  0.41 106.51 ? 357  GLU A CG  1 
ATOM   558  C  CD  . GLU A 1 94  ? -4.758  -28.928 -1.101  0.41 104.96 ? 357  GLU A CD  1 
ATOM   559  O  OE1 . GLU A 1 94  ? -4.489  -29.025 0.113   0.41 100.43 ? 357  GLU A OE1 1 
ATOM   560  O  OE2 . GLU A 1 94  ? -5.834  -29.318 -1.599  0.41 102.36 ? 357  GLU A OE2 1 
ATOM   561  N  N   . LYS A 1 95  ? -4.173  -28.635 -6.805  0.41 110.42 ? 358  LYS A N   1 
ATOM   562  C  CA  . LYS A 1 95  ? -3.652  -28.072 -8.082  0.41 106.45 ? 358  LYS A CA  1 
ATOM   563  C  C   . LYS A 1 95  ? -4.473  -26.842 -8.496  0.41 101.10 ? 358  LYS A C   1 
ATOM   564  O  O   . LYS A 1 95  ? -4.070  -26.159 -9.461  0.41 93.69  ? 358  LYS A O   1 
ATOM   565  C  CB  . LYS A 1 95  ? -3.694  -29.138 -9.182  0.41 107.23 ? 358  LYS A CB  1 
ATOM   566  C  CG  . LYS A 1 95  ? -2.885  -28.812 -10.431 0.41 104.86 ? 358  LYS A CG  1 
ATOM   567  C  CD  . LYS A 1 95  ? -2.527  -30.032 -11.250 0.41 103.80 ? 358  LYS A CD  1 
ATOM   568  C  CE  . LYS A 1 95  ? -1.345  -29.801 -12.167 0.41 103.35 ? 358  LYS A CE  1 
ATOM   569  N  NZ  . LYS A 1 95  ? -0.715  -31.079 -12.570 0.41 102.72 ? 358  LYS A NZ  1 
ATOM   570  N  N   . VAL A 1 96  ? -5.577  -26.566 -7.796  0.41 98.83  ? 359  VAL A N   1 
ATOM   571  C  CA  . VAL A 1 96  ? -6.493  -25.428 -8.105  0.41 100.52 ? 359  VAL A CA  1 
ATOM   572  C  C   . VAL A 1 96  ? -5.788  -24.107 -7.761  0.41 100.60 ? 359  VAL A C   1 
ATOM   573  O  O   . VAL A 1 96  ? -5.961  -23.140 -8.529  0.41 100.42 ? 359  VAL A O   1 
ATOM   574  C  CB  . VAL A 1 96  ? -7.847  -25.579 -7.381  0.41 99.56  ? 359  VAL A CB  1 
ATOM   575  C  CG1 . VAL A 1 96  ? -7.778  -25.185 -5.911  0.41 98.57  ? 359  VAL A CG1 1 
ATOM   576  C  CG2 . VAL A 1 96  ? -8.947  -24.813 -8.098  0.41 97.37  ? 359  VAL A CG2 1 
ATOM   577  N  N   . ASP A 1 97  ? -5.007  -24.077 -6.672  1.00 99.45  ? 360  ASP A N   1 
ATOM   578  C  CA  . ASP A 1 97  ? -4.316  -22.844 -6.189  1.00 94.30  ? 360  ASP A CA  1 
ATOM   579  C  C   . ASP A 1 97  ? -2.928  -22.707 -6.861  1.00 98.55  ? 360  ASP A C   1 
ATOM   580  O  O   . ASP A 1 97  ? -1.968  -22.319 -6.152  1.00 104.09 ? 360  ASP A O   1 
ATOM   581  C  CB  . ASP A 1 97  ? -4.286  -22.803 -4.650  1.00 82.42  ? 360  ASP A CB  1 
ATOM   582  C  CG  . ASP A 1 97  ? -4.241  -21.409 -4.023  1.00 79.47  ? 360  ASP A CG  1 
ATOM   583  O  OD1 . ASP A 1 97  ? -4.262  -20.402 -4.769  1.00 76.91  ? 360  ASP A OD1 1 
ATOM   584  O  OD2 . ASP A 1 97  ? -4.180  -21.326 -2.779  1.00 82.28  ? 360  ASP A OD2 1 
ATOM   585  N  N   . THR A 1 98  ? -2.819  -22.970 -8.179  1.00 88.93  ? 361  THR A N   1 
ATOM   586  C  CA  . THR A 1 98  ? -1.677  -22.585 -9.060  1.00 86.27  ? 361  THR A CA  1 
ATOM   587  C  C   . THR A 1 98  ? -2.137  -21.479 -10.022 1.00 79.06  ? 361  THR A C   1 
ATOM   588  O  O   . THR A 1 98  ? -3.354  -21.291 -10.176 1.00 77.34  ? 361  THR A O   1 
ATOM   589  C  CB  . THR A 1 98  ? -1.089  -23.788 -9.822  1.00 84.32  ? 361  THR A CB  1 
ATOM   590  O  OG1 . THR A 1 98  ? -2.139  -24.469 -10.516 1.00 75.38  ? 361  THR A OG1 1 
ATOM   591  C  CG2 . THR A 1 98  ? -0.347  -24.749 -8.915  1.00 79.97  ? 361  THR A CG2 1 
ATOM   592  N  N   . ARG A 1 99  ? -1.190  -20.766 -10.630 1.00 80.38  ? 362  ARG A N   1 
ATOM   593  C  CA  . ARG A 1 99  ? -1.444  -19.706 -11.636 1.00 92.31  ? 362  ARG A CA  1 
ATOM   594  C  C   . ARG A 1 99  ? -0.827  -20.181 -12.954 1.00 97.37  ? 362  ARG A C   1 
ATOM   595  O  O   . ARG A 1 99  ? 0.022   -21.102 -12.899 1.00 93.66  ? 362  ARG A O   1 
ATOM   596  C  CB  . ARG A 1 99  ? -0.843  -18.375 -11.170 1.00 108.17 ? 362  ARG A CB  1 
ATOM   597  C  CG  . ARG A 1 99  ? -1.737  -17.160 -11.388 1.00 118.88 ? 362  ARG A CG  1 
ATOM   598  C  CD  . ARG A 1 99  ? -0.921  -15.877 -11.405 1.00 127.45 ? 362  ARG A CD  1 
ATOM   599  N  NE  . ARG A 1 99  ? 0.029   -15.860 -12.518 1.00 136.59 ? 362  ARG A NE  1 
ATOM   600  C  CZ  . ARG A 1 99  ? 1.057   -15.022 -12.651 1.00 124.33 ? 362  ARG A CZ  1 
ATOM   601  N  NH1 . ARG A 1 99  ? 1.297   -14.095 -11.737 1.00 124.71 ? 362  ARG A NH1 1 
ATOM   602  N  NH2 . ARG A 1 99  ? 1.847   -15.120 -13.708 1.00 112.06 ? 362  ARG A NH2 1 
ATOM   603  N  N   . THR A 1 100 ? -1.244  -19.599 -14.083 1.00 88.59  ? 363  THR A N   1 
ATOM   604  C  CA  . THR A 1 100 ? -0.723  -19.930 -15.431 1.00 79.80  ? 363  THR A CA  1 
ATOM   605  C  C   . THR A 1 100 ? -0.249  -18.642 -16.096 1.00 75.07  ? 363  THR A C   1 
ATOM   606  O  O   . THR A 1 100 ? -1.066  -17.742 -16.285 1.00 92.90  ? 363  THR A O   1 
ATOM   607  C  CB  . THR A 1 100 ? -1.765  -20.689 -16.259 1.00 86.28  ? 363  THR A CB  1 
ATOM   608  O  OG1 . THR A 1 100 ? -2.249  -21.775 -15.471 1.00 78.33  ? 363  THR A OG1 1 
ATOM   609  C  CG2 . THR A 1 100 ? -1.205  -21.221 -17.560 1.00 85.93  ? 363  THR A CG2 1 
ATOM   610  N  N   . GLN A 1 101 ? 1.041   -18.572 -16.415 1.00 76.30  ? 364  GLN A N   1 
ATOM   611  C  CA  . GLN A 1 101 ? 1.691   -17.397 -17.042 1.00 75.89  ? 364  GLN A CA  1 
ATOM   612  C  C   . GLN A 1 101 ? 0.955   -17.068 -18.351 1.00 69.93  ? 364  GLN A C   1 
ATOM   613  O  O   . GLN A 1 101 ? 0.461   -17.993 -18.988 1.00 71.20  ? 364  GLN A O   1 
ATOM   614  C  CB  . GLN A 1 101 ? 3.185   -17.691 -17.237 1.00 71.44  ? 364  GLN A CB  1 
ATOM   615  C  CG  . GLN A 1 101 ? 3.887   -16.650 -18.104 1.00 85.38  ? 364  GLN A CG  1 
ATOM   616  C  CD  . GLN A 1 101 ? 5.338   -16.423 -17.745 1.00 94.11  ? 364  GLN A CD  1 
ATOM   617  O  OE1 . GLN A 1 101 ? 6.107   -17.372 -17.585 1.00 101.72 ? 364  GLN A OE1 1 
ATOM   618  N  NE2 . GLN A 1 101 ? 5.721   -15.156 -17.623 1.00 84.53  ? 364  GLN A NE2 1 
ATOM   619  N  N   . GLU A 1 102 ? 0.909   -15.794 -18.743 1.00 73.89  ? 365  GLU A N   1 
ATOM   620  C  CA  . GLU A 1 102 ? 0.299   -15.334 -20.019 1.00 70.36  ? 365  GLU A CA  1 
ATOM   621  C  C   . GLU A 1 102 ? 1.193   -15.749 -21.186 1.00 62.58  ? 365  GLU A C   1 
ATOM   622  O  O   . GLU A 1 102 ? 2.402   -15.523 -21.196 1.00 54.48  ? 365  GLU A O   1 
ATOM   623  C  CB  . GLU A 1 102 ? 0.027   -13.821 -20.004 1.00 82.60  ? 365  GLU A CB  1 
ATOM   624  C  CG  . GLU A 1 102 ? -0.459  -13.259 -21.344 1.00 94.49  ? 365  GLU A CG  1 
ATOM   625  C  CD  . GLU A 1 102 ? -1.630  -12.280 -21.329 1.00 105.98 ? 365  GLU A CD  1 
ATOM   626  O  OE1 . GLU A 1 102 ? -1.476  -11.175 -21.897 1.00 114.73 ? 365  GLU A OE1 1 
ATOM   627  O  OE2 . GLU A 1 102 ? -2.714  -12.637 -20.810 1.00 108.39 ? 365  GLU A OE2 1 
ATOM   628  N  N   . PRO A 1 103 ? 0.613   -16.346 -22.248 1.00 56.09  ? 366  PRO A N   1 
ATOM   629  C  CA  . PRO A 1 103 ? 1.397   -16.735 -23.412 1.00 53.97  ? 366  PRO A CA  1 
ATOM   630  C  C   . PRO A 1 103 ? 2.061   -15.500 -24.024 1.00 53.98  ? 366  PRO A C   1 
ATOM   631  O  O   . PRO A 1 103 ? 1.621   -14.437 -23.733 1.00 50.29  ? 366  PRO A O   1 
ATOM   632  C  CB  . PRO A 1 103 ? 0.355   -17.361 -24.349 1.00 53.73  ? 366  PRO A CB  1 
ATOM   633  C  CG  . PRO A 1 103 ? -0.710  -17.844 -23.400 1.00 54.33  ? 366  PRO A CG  1 
ATOM   634  C  CD  . PRO A 1 103 ? -0.799  -16.734 -22.376 1.00 55.15  ? 366  PRO A CD  1 
ATOM   635  N  N   . LYS A 1 104 ? 3.091   -15.722 -24.836 1.00 54.08  ? 367  LYS A N   1 
ATOM   636  C  CA  . LYS A 1 104 ? 3.817   -14.699 -25.635 1.00 58.41  ? 367  LYS A CA  1 
ATOM   637  C  C   . LYS A 1 104 ? 2.903   -14.186 -26.761 1.00 59.63  ? 367  LYS A C   1 
ATOM   638  O  O   . LYS A 1 104 ? 1.893   -14.829 -27.065 1.00 54.49  ? 367  LYS A O   1 
ATOM   639  C  CB  . LYS A 1 104 ? 5.092   -15.301 -26.255 1.00 66.21  ? 367  LYS A CB  1 
ATOM   640  C  CG  . LYS A 1 104 ? 6.054   -16.044 -25.325 1.00 69.90  ? 367  LYS A CG  1 
ATOM   641  C  CD  . LYS A 1 104 ? 6.772   -15.165 -24.339 1.00 76.23  ? 367  LYS A CD  1 
ATOM   642  C  CE  . LYS A 1 104 ? 7.503   -15.942 -23.267 1.00 75.71  ? 367  LYS A CE  1 
ATOM   643  N  NZ  . LYS A 1 104 ? 7.140   -15.449 -21.913 1.00 70.29  ? 367  LYS A NZ  1 
ATOM   644  N  N   . GLU A 1 105 ? 3.330   -13.132 -27.448 1.00 54.38  ? 368  GLU A N   1 
ATOM   645  C  CA  . GLU A 1 105 ? 2.561   -12.426 -28.494 1.00 56.82  ? 368  GLU A CA  1 
ATOM   646  C  C   . GLU A 1 105 ? 2.342   -13.360 -29.684 1.00 50.98  ? 368  GLU A C   1 
ATOM   647  O  O   . GLU A 1 105 ? 1.190   -13.411 -30.166 1.00 52.33  ? 368  GLU A O   1 
ATOM   648  C  CB  . GLU A 1 105 ? 3.273   -11.121 -28.891 1.00 66.28  ? 368  GLU A CB  1 
ATOM   649  C  CG  . GLU A 1 105 ? 3.255   -10.081 -27.770 1.00 73.10  ? 368  GLU A CG  1 
ATOM   650  C  CD  . GLU A 1 105 ? 1.867   -9.734  -27.240 1.00 77.83  ? 368  GLU A CD  1 
ATOM   651  O  OE1 . GLU A 1 105 ? 1.013   -9.337  -28.060 1.00 91.59  ? 368  GLU A OE1 1 
ATOM   652  O  OE2 . GLU A 1 105 ? 1.626   -9.879  -26.025 1.00 70.81  ? 368  GLU A OE2 1 
ATOM   653  N  N   . GLY A 1 106 ? 3.400   -14.032 -30.151 1.00 43.33  ? 369  GLY A N   1 
ATOM   654  C  CA  . GLY A 1 106 ? 3.331   -15.017 -31.236 1.00 41.40  ? 369  GLY A CA  1 
ATOM   655  C  C   . GLY A 1 106 ? 2.293   -16.121 -30.908 1.00 38.85  ? 369  GLY A C   1 
ATOM   656  O  O   . GLY A 1 106 ? 1.468   -16.416 -31.788 1.00 40.23  ? 369  GLY A O   1 
ATOM   657  N  N   . THR A 1 107 ? 2.322   -16.693 -29.707 1.00 37.79  ? 370  THR A N   1 
ATOM   658  C  CA  . THR A 1 107 ? 1.364   -17.758 -29.269 1.00 44.05  ? 370  THR A CA  1 
ATOM   659  C  C   . THR A 1 107 ? -0.094  -17.263 -29.334 1.00 45.46  ? 370  THR A C   1 
ATOM   660  O  O   . THR A 1 107 ? -0.936  -17.924 -29.973 1.00 40.69  ? 370  THR A O   1 
ATOM   661  C  CB  . THR A 1 107 ? 1.706   -18.277 -27.881 1.00 45.71  ? 370  THR A CB  1 
ATOM   662  O  OG1 . THR A 1 107 ? 3.122   -18.473 -27.900 1.00 43.64  ? 370  THR A OG1 1 
ATOM   663  C  CG2 . THR A 1 107 ? 0.975   -19.571 -27.572 1.00 47.41  ? 370  THR A CG2 1 
ATOM   664  N  N   . LYS A 1 108 ? -0.363  -16.115 -28.704 0.41 46.50  ? 371  LYS A N   1 
ATOM   665  C  CA  . LYS A 1 108 ? -1.703  -15.469 -28.624 0.41 47.66  ? 371  LYS A CA  1 
ATOM   666  C  C   . LYS A 1 108 ? -2.256  -15.201 -30.031 0.41 46.93  ? 371  LYS A C   1 
ATOM   667  O  O   . LYS A 1 108 ? -3.463  -15.428 -30.235 0.41 46.80  ? 371  LYS A O   1 
ATOM   668  C  CB  . LYS A 1 108 ? -1.616  -14.189 -27.788 0.41 50.76  ? 371  LYS A CB  1 
ATOM   669  C  CG  . LYS A 1 108 ? -1.318  -14.417 -26.313 0.41 53.58  ? 371  LYS A CG  1 
ATOM   670  C  CD  . LYS A 1 108 ? -1.597  -13.216 -25.436 0.41 56.34  ? 371  LYS A CD  1 
ATOM   671  C  CE  . LYS A 1 108 ? -0.587  -12.104 -25.609 0.41 59.35  ? 371  LYS A CE  1 
ATOM   672  N  NZ  . LYS A 1 108 ? -0.611  -11.173 -24.456 0.41 61.84  ? 371  LYS A NZ  1 
ATOM   673  N  N   . LYS A 1 109 ? -1.413  -14.759 -30.969 0.41 45.83  ? 372  LYS A N   1 
ATOM   674  C  CA  . LYS A 1 109 ? -1.789  -14.561 -32.397 0.41 47.85  ? 372  LYS A CA  1 
ATOM   675  C  C   . LYS A 1 109 ? -2.136  -15.917 -33.036 0.41 46.36  ? 372  LYS A C   1 
ATOM   676  O  O   . LYS A 1 109 ? -3.162  -15.980 -33.740 0.41 47.18  ? 372  LYS A O   1 
ATOM   677  C  CB  . LYS A 1 109 ? -0.665  -13.833 -33.145 0.41 50.27  ? 372  LYS A CB  1 
ATOM   678  C  CG  . LYS A 1 109 ? -0.852  -13.673 -34.651 0.41 54.87  ? 372  LYS A CG  1 
ATOM   679  C  CD  . LYS A 1 109 ? -2.086  -12.876 -35.071 0.41 60.38  ? 372  LYS A CD  1 
ATOM   680  C  CE  . LYS A 1 109 ? -2.029  -11.412 -34.683 0.41 61.64  ? 372  LYS A CE  1 
ATOM   681  N  NZ  . LYS A 1 109 ? -2.989  -10.605 -35.473 0.41 61.40  ? 372  LYS A NZ  1 
ATOM   682  N  N   . LEU A 1 110 ? -1.315  -16.953 -32.806 1.00 45.03  ? 373  LEU A N   1 
ATOM   683  C  CA  . LEU A 1 110 ? -1.518  -18.327 -33.389 1.00 43.91  ? 373  LEU A CA  1 
ATOM   684  C  C   . LEU A 1 110 ? -2.877  -18.861 -32.910 1.00 31.35  ? 373  LEU A C   1 
ATOM   685  O  O   . LEU A 1 110 ? -3.678  -19.352 -33.744 1.00 36.61  ? 373  LEU A O   1 
ATOM   686  C  CB  . LEU A 1 110 ? -0.395  -19.280 -32.947 1.00 43.77  ? 373  LEU A CB  1 
ATOM   687  C  CG  . LEU A 1 110 ? 0.959   -19.062 -33.627 1.00 40.62  ? 373  LEU A CG  1 
ATOM   688  C  CD1 . LEU A 1 110 ? 2.081   -19.730 -32.849 1.00 37.63  ? 373  LEU A CD1 1 
ATOM   689  C  CD2 . LEU A 1 110 ? 0.905   -19.549 -35.074 1.00 44.60  ? 373  LEU A CD2 1 
ATOM   690  N  N   . MET A 1 111 ? -3.141  -18.706 -31.639 1.00 28.01  ? 374  MET A N   1 
ATOM   691  C  CA  . MET A 1 111 ? -4.387  -19.200 -31.015 1.00 33.06  ? 374  MET A CA  1 
ATOM   692  C  C   . MET A 1 111 ? -5.617  -18.467 -31.599 1.00 38.98  ? 374  MET A C   1 
ATOM   693  O  O   . MET A 1 111 ? -6.653  -19.146 -31.903 1.00 33.32  ? 374  MET A O   1 
ATOM   694  C  CB  . MET A 1 111 ? -4.344  -19.075 -29.484 1.00 33.34  ? 374  MET A CB  1 
ATOM   695  C  CG  . MET A 1 111 ? -3.334  -20.020 -28.830 1.00 34.77  ? 374  MET A CG  1 
ATOM   696  S  SD  . MET A 1 111 ? -3.483  -20.201 -27.037 1.00 44.52  ? 374  MET A SD  1 
ATOM   697  C  CE  . MET A 1 111 ? -2.996  -18.580 -26.478 1.00 42.25  ? 374  MET A CE  1 
ATOM   698  N  N   . LYS A 1 112 ? -5.546  -17.135 -31.715 0.41 37.44  ? 375  LYS A N   1 
ATOM   699  C  CA  . LYS A 1 112 ? -6.685  -16.280 -32.152 0.41 38.87  ? 375  LYS A CA  1 
ATOM   700  C  C   . LYS A 1 112 ? -7.063  -16.644 -33.589 0.41 37.95  ? 375  LYS A C   1 
ATOM   701  O  O   . LYS A 1 112 ? -8.259  -16.876 -33.837 0.41 37.08  ? 375  LYS A O   1 
ATOM   702  C  CB  . LYS A 1 112 ? -6.339  -14.790 -32.054 0.41 43.15  ? 375  LYS A CB  1 
ATOM   703  C  CG  . LYS A 1 112 ? -7.398  -13.836 -32.603 0.41 42.29  ? 375  LYS A CG  1 
ATOM   704  C  CD  . LYS A 1 112 ? -7.316  -12.456 -31.981 0.41 44.70  ? 375  LYS A CD  1 
ATOM   705  C  CE  . LYS A 1 112 ? -8.174  -11.416 -32.673 0.41 44.82  ? 375  LYS A CE  1 
ATOM   706  N  NZ  . LYS A 1 112 ? -7.711  -10.049 -32.331 0.41 45.80  ? 375  LYS A NZ  1 
ATOM   707  N  N   . ILE A 1 113 ? -6.071  -16.722 -34.478 0.41 36.97  ? 376  ILE A N   1 
ATOM   708  C  CA  . ILE A 1 113 ? -6.241  -17.098 -35.914 0.41 37.99  ? 376  ILE A CA  1 
ATOM   709  C  C   . ILE A 1 113 ? -6.843  -18.507 -36.007 0.41 39.89  ? 376  ILE A C   1 
ATOM   710  O  O   . ILE A 1 113 ? -7.791  -18.706 -36.815 0.41 37.93  ? 376  ILE A O   1 
ATOM   711  C  CB  . ILE A 1 113 ? -4.896  -17.019 -36.662 0.41 38.29  ? 376  ILE A CB  1 
ATOM   712  C  CG1 . ILE A 1 113 ? -4.345  -15.591 -36.701 0.41 42.39  ? 376  ILE A CG1 1 
ATOM   713  C  CG2 . ILE A 1 113 ? -5.012  -17.602 -38.061 0.41 38.55  ? 376  ILE A CG2 1 
ATOM   714  C  CD1 . ILE A 1 113 ? -2.861  -15.528 -36.987 0.41 42.15  ? 376  ILE A CD1 1 
ATOM   715  N  N   . THR A 1 114 ? -6.285  -19.457 -35.247 1.00 39.37  ? 377  THR A N   1 
ATOM   716  C  CA  . THR A 1 114 ? -6.733  -20.866 -35.268 1.00 34.71  ? 377  THR A CA  1 
ATOM   717  C  C   . THR A 1 114 ? -8.160  -20.973 -34.735 1.00 28.16  ? 377  THR A C   1 
ATOM   718  O  O   . THR A 1 114 ? -8.989  -21.618 -35.428 1.00 30.22  ? 377  THR A O   1 
ATOM   719  C  CB  . THR A 1 114 ? -5.754  -21.774 -34.534 1.00 37.31  ? 377  THR A CB  1 
ATOM   720  O  OG1 . THR A 1 114 ? -4.480  -21.551 -35.150 1.00 30.95  ? 377  THR A OG1 1 
ATOM   721  C  CG2 . THR A 1 114 ? -6.127  -23.224 -34.703 1.00 35.46  ? 377  THR A CG2 1 
ATOM   722  N  N   . ALA A 1 115 ? -8.460  -20.333 -33.617 1.00 29.67  ? 378  ALA A N   1 
ATOM   723  C  CA  . ALA A 1 115 ? -9.813  -20.320 -33.017 1.00 33.15  ? 378  ALA A CA  1 
ATOM   724  C  C   . ALA A 1 115 ? -10.854 -19.721 -33.978 1.00 38.08  ? 378  ALA A C   1 
ATOM   725  O  O   . ALA A 1 115 ? -11.988 -20.347 -34.167 1.00 34.68  ? 378  ALA A O   1 
ATOM   726  C  CB  . ALA A 1 115 ? -9.801  -19.608 -31.708 1.00 34.74  ? 378  ALA A CB  1 
ATOM   727  N  N   . GLU A 1 116 ? -10.528 -18.575 -34.590 0.41 34.79  ? 379  GLU A N   1 
ATOM   728  C  CA  . GLU A 1 116 ? -11.375 -17.909 -35.626 0.41 35.73  ? 379  GLU A CA  1 
ATOM   729  C  C   . GLU A 1 116 ? -11.731 -18.944 -36.692 0.41 35.24  ? 379  GLU A C   1 
ATOM   730  O  O   . GLU A 1 116 ? -12.933 -19.142 -36.965 0.41 35.69  ? 379  GLU A O   1 
ATOM   731  C  CB  . GLU A 1 116 ? -10.665 -16.706 -36.271 0.41 35.95  ? 379  GLU A CB  1 
ATOM   732  C  CG  . GLU A 1 116 ? -11.396 -16.136 -37.486 0.41 37.04  ? 379  GLU A CG  1 
ATOM   733  C  CD  . GLU A 1 116 ? -10.820 -14.876 -38.134 0.41 37.37  ? 379  GLU A CD  1 
ATOM   734  O  OE1 . GLU A 1 116 ? -9.759  -14.393 -37.691 0.41 36.18  ? 379  GLU A OE1 1 
ATOM   735  O  OE2 . GLU A 1 116 ? -11.437 -14.384 -39.107 0.41 40.43  ? 379  GLU A OE2 1 
ATOM   736  N  N   . TRP A 1 117 ? -10.710 -19.589 -37.258 1.00 33.10  ? 380  TRP A N   1 
ATOM   737  C  CA  . TRP A 1 117 ? -10.877 -20.534 -38.365 1.00 31.37  ? 380  TRP A CA  1 
ATOM   738  C  C   . TRP A 1 117 ? -11.713 -21.757 -37.901 1.00 33.59  ? 380  TRP A C   1 
ATOM   739  O  O   . TRP A 1 117 ? -12.624 -22.225 -38.660 1.00 30.93  ? 380  TRP A O   1 
ATOM   740  C  CB  . TRP A 1 117 ? -9.475  -20.909 -38.842 1.00 32.76  ? 380  TRP A CB  1 
ATOM   741  C  CG  . TRP A 1 117 ? -9.556  -21.947 -39.882 1.00 26.76  ? 380  TRP A CG  1 
ATOM   742  C  CD1 . TRP A 1 117 ? -9.679  -21.724 -41.206 1.00 29.00  ? 380  TRP A CD1 1 
ATOM   743  C  CD2 . TRP A 1 117 ? -9.561  -23.367 -39.693 1.00 29.63  ? 380  TRP A CD2 1 
ATOM   744  N  NE1 . TRP A 1 117 ? -9.739  -22.905 -41.874 1.00 31.89  ? 380  TRP A NE1 1 
ATOM   745  C  CE2 . TRP A 1 117 ? -9.634  -23.941 -40.969 1.00 30.47  ? 380  TRP A CE2 1 
ATOM   746  C  CE3 . TRP A 1 117 ? -9.404  -24.215 -38.592 1.00 31.82  ? 380  TRP A CE3 1 
ATOM   747  C  CZ2 . TRP A 1 117 ? -9.658  -25.324 -41.167 1.00 33.78  ? 380  TRP A CZ2 1 
ATOM   748  C  CZ3 . TRP A 1 117 ? -9.416  -25.571 -38.788 1.00 25.45  ? 380  TRP A CZ3 1 
ATOM   749  C  CH2 . TRP A 1 117 ? -9.559  -26.124 -40.048 1.00 29.50  ? 380  TRP A CH2 1 
ATOM   750  N  N   . LEU A 1 118 ? -11.491 -22.216 -36.666 1.00 29.56  ? 381  LEU A N   1 
ATOM   751  C  CA  . LEU A 1 118 ? -12.094 -23.477 -36.190 1.00 30.20  ? 381  LEU A CA  1 
ATOM   752  C  C   . LEU A 1 118 ? -13.590 -23.261 -35.919 1.00 27.00  ? 381  LEU A C   1 
ATOM   753  O  O   . LEU A 1 118 ? -14.398 -24.118 -36.371 1.00 29.35  ? 381  LEU A O   1 
ATOM   754  C  CB  . LEU A 1 118 ? -11.342 -23.959 -34.946 1.00 29.26  ? 381  LEU A CB  1 
ATOM   755  C  CG  . LEU A 1 118 ? -11.729 -25.358 -34.492 1.00 30.83  ? 381  LEU A CG  1 
ATOM   756  C  CD1 . LEU A 1 118 ? -11.523 -26.360 -35.603 1.00 30.39  ? 381  LEU A CD1 1 
ATOM   757  C  CD2 . LEU A 1 118 ? -10.955 -25.736 -33.242 1.00 32.47  ? 381  LEU A CD2 1 
ATOM   758  N  N   . TRP A 1 119 ? -13.970 -22.136 -35.289 1.00 31.36  ? 382  TRP A N   1 
ATOM   759  C  CA  . TRP A 1 119 ? -15.420 -21.794 -35.103 1.00 34.43  ? 382  TRP A CA  1 
ATOM   760  C  C   . TRP A 1 119 ? -16.148 -21.667 -36.453 1.00 35.64  ? 382  TRP A C   1 
ATOM   761  O  O   . TRP A 1 119 ? -17.236 -22.332 -36.612 1.00 37.08  ? 382  TRP A O   1 
ATOM   762  C  CB  . TRP A 1 119 ? -15.584 -20.561 -34.249 1.00 32.91  ? 382  TRP A CB  1 
ATOM   763  C  CG  . TRP A 1 119 ? -15.409 -20.780 -32.783 1.00 28.25  ? 382  TRP A CG  1 
ATOM   764  C  CD1 . TRP A 1 119 ? -14.611 -20.034 -31.981 1.00 31.68  ? 382  TRP A CD1 1 
ATOM   765  C  CD2 . TRP A 1 119 ? -16.076 -21.725 -31.923 1.00 28.10  ? 382  TRP A CD2 1 
ATOM   766  N  NE1 . TRP A 1 119 ? -14.752 -20.408 -30.689 1.00 29.91  ? 382  TRP A NE1 1 
ATOM   767  C  CE2 . TRP A 1 119 ? -15.635 -21.456 -30.621 1.00 27.48  ? 382  TRP A CE2 1 
ATOM   768  C  CE3 . TRP A 1 119 ? -17.029 -22.740 -32.102 1.00 29.80  ? 382  TRP A CE3 1 
ATOM   769  C  CZ2 . TRP A 1 119 ? -16.008 -22.228 -29.531 1.00 25.72  ? 382  TRP A CZ2 1 
ATOM   770  C  CZ3 . TRP A 1 119 ? -17.438 -23.474 -31.016 1.00 27.75  ? 382  TRP A CZ3 1 
ATOM   771  C  CH2 . TRP A 1 119 ? -16.930 -23.213 -29.743 1.00 25.84  ? 382  TRP A CH2 1 
ATOM   772  N  N   . LYS A 1 120 ? -15.514 -21.059 -37.462 1.00 35.25  ? 383  LYS A N   1 
ATOM   773  C  CA  . LYS A 1 120 ? -16.091 -21.022 -38.820 1.00 34.75  ? 383  LYS A CA  1 
ATOM   774  C  C   . LYS A 1 120 ? -16.286 -22.419 -39.371 1.00 33.03  ? 383  LYS A C   1 
ATOM   775  O  O   . LYS A 1 120 ? -17.366 -22.669 -39.896 1.00 34.06  ? 383  LYS A O   1 
ATOM   776  C  CB  . LYS A 1 120 ? -15.291 -20.240 -39.867 1.00 50.01  ? 383  LYS A CB  1 
ATOM   777  C  CG  . LYS A 1 120 ? -15.337 -18.724 -39.758 1.00 61.28  ? 383  LYS A CG  1 
ATOM   778  C  CD  . LYS A 1 120 ? -14.933 -18.024 -41.059 1.00 75.23  ? 383  LYS A CD  1 
ATOM   779  C  CE  . LYS A 1 120 ? -14.916 -16.506 -40.934 1.00 83.53  ? 383  LYS A CE  1 
ATOM   780  N  NZ  . LYS A 1 120 ? -14.014 -16.038 -39.848 1.00 82.09  ? 383  LYS A NZ  1 
ATOM   781  N  N   . GLU A 1 121 ? -15.290 -23.305 -39.282 0.21 27.23  ? 384  GLU A N   1 
ATOM   782  C  CA  . GLU A 1 121 ? -15.386 -24.632 -39.941 0.21 25.77  ? 384  GLU A CA  1 
ATOM   783  C  C   . GLU A 1 121 ? -16.461 -25.454 -39.237 0.21 26.28  ? 384  GLU A C   1 
ATOM   784  O  O   . GLU A 1 121 ? -17.140 -26.222 -39.912 0.21 25.63  ? 384  GLU A O   1 
ATOM   785  C  CB  . GLU A 1 121 ? -14.058 -25.388 -39.909 0.21 23.94  ? 384  GLU A CB  1 
ATOM   786  C  CG  . GLU A 1 121 ? -12.933 -24.569 -40.474 0.21 24.06  ? 384  GLU A CG  1 
ATOM   787  C  CD  . GLU A 1 121 ? -12.971 -24.403 -41.979 0.21 22.92  ? 384  GLU A CD  1 
ATOM   788  O  OE1 . GLU A 1 121 ? -12.667 -23.294 -42.423 0.21 22.09  ? 384  GLU A OE1 1 
ATOM   789  O  OE2 . GLU A 1 121 ? -13.288 -25.400 -42.699 0.21 21.55  ? 384  GLU A OE2 1 
ATOM   790  N  N   . LEU A 1 122 ? -16.553 -25.297 -37.911 0.41 30.35  ? 385  LEU A N   1 
ATOM   791  C  CA  . LEU A 1 122 ? -17.547 -26.068 -37.113 0.41 28.74  ? 385  LEU A CA  1 
ATOM   792  C  C   . LEU A 1 122 ? -18.946 -25.527 -37.438 0.41 28.89  ? 385  LEU A C   1 
ATOM   793  O  O   . LEU A 1 122 ? -19.854 -26.344 -37.686 0.41 24.29  ? 385  LEU A O   1 
ATOM   794  C  CB  . LEU A 1 122 ? -17.230 -25.919 -35.618 0.41 27.78  ? 385  LEU A CB  1 
ATOM   795  C  CG  . LEU A 1 122 ? -16.110 -26.808 -35.073 0.41 27.80  ? 385  LEU A CG  1 
ATOM   796  C  CD1 . LEU A 1 122 ? -15.644 -26.322 -33.708 0.41 28.33  ? 385  LEU A CD1 1 
ATOM   797  C  CD2 . LEU A 1 122 ? -16.561 -28.257 -34.988 0.41 27.88  ? 385  LEU A CD2 1 
ATOM   798  N  N   . GLY A 1 123 ? -19.082 -24.198 -37.464 0.41 29.51  ? 386  GLY A N   1 
ATOM   799  C  CA  . GLY A 1 123 ? -20.366 -23.490 -37.640 0.41 31.80  ? 386  GLY A CA  1 
ATOM   800  C  C   . GLY A 1 123 ? -20.809 -23.365 -39.090 0.41 33.61  ? 386  GLY A C   1 
ATOM   801  O  O   . GLY A 1 123 ? -21.862 -22.723 -39.298 0.41 31.33  ? 386  GLY A O   1 
ATOM   802  N  N   . LYS A 1 124 ? -20.077 -23.955 -40.047 0.41 35.35  ? 387  LYS A N   1 
ATOM   803  C  CA  . LYS A 1 124 ? -20.443 -23.958 -41.494 0.41 38.83  ? 387  LYS A CA  1 
ATOM   804  C  C   . LYS A 1 124 ? -21.727 -24.770 -41.725 0.41 40.83  ? 387  LYS A C   1 
ATOM   805  O  O   . LYS A 1 124 ? -22.565 -24.305 -42.509 0.41 43.39  ? 387  LYS A O   1 
ATOM   806  C  CB  . LYS A 1 124 ? -19.304 -24.500 -42.365 0.41 38.45  ? 387  LYS A CB  1 
ATOM   807  C  CG  . LYS A 1 124 ? -18.350 -23.440 -42.901 0.41 39.51  ? 387  LYS A CG  1 
ATOM   808  C  CD  . LYS A 1 124 ? -17.091 -23.987 -43.555 0.41 40.35  ? 387  LYS A CD  1 
ATOM   809  C  CE  . LYS A 1 124 ? -16.108 -22.893 -43.916 0.41 40.46  ? 387  LYS A CE  1 
ATOM   810  N  NZ  . LYS A 1 124 ? -14.835 -23.437 -44.446 0.41 40.53  ? 387  LYS A NZ  1 
ATOM   811  N  N   . LYS A 1 125 ? -21.870 -25.944 -41.102 0.41 39.40  ? 388  LYS A N   1 
ATOM   812  C  CA  . LYS A 1 125 ? -23.027 -26.857 -41.319 0.41 40.46  ? 388  LYS A CA  1 
ATOM   813  C  C   . LYS A 1 125 ? -23.982 -26.831 -40.115 0.41 37.65  ? 388  LYS A C   1 
ATOM   814  O  O   . LYS A 1 125 ? -24.917 -27.637 -40.101 0.41 39.15  ? 388  LYS A O   1 
ATOM   815  C  CB  . LYS A 1 125 ? -22.532 -28.286 -41.546 0.41 42.85  ? 388  LYS A CB  1 
ATOM   816  C  CG  . LYS A 1 125 ? -21.607 -28.472 -42.738 0.41 47.22  ? 388  LYS A CG  1 
ATOM   817  C  CD  . LYS A 1 125 ? -21.217 -29.923 -42.970 0.41 51.42  ? 388  LYS A CD  1 
ATOM   818  C  CE  . LYS A 1 125 ? -20.343 -30.499 -41.874 0.41 53.83  ? 388  LYS A CE  1 
ATOM   819  N  NZ  . LYS A 1 125 ? -20.081 -31.945 -42.077 0.41 55.57  ? 388  LYS A NZ  1 
ATOM   820  N  N   . LYS A 1 126 ? -23.753 -25.955 -39.136 0.41 36.45  ? 389  LYS A N   1 
ATOM   821  C  CA  . LYS A 1 126 ? -24.518 -25.932 -37.865 0.41 38.31  ? 389  LYS A CA  1 
ATOM   822  C  C   . LYS A 1 126 ? -24.900 -24.489 -37.543 0.41 39.12  ? 389  LYS A C   1 
ATOM   823  O  O   . LYS A 1 126 ? -24.027 -23.608 -37.653 0.41 37.50  ? 389  LYS A O   1 
ATOM   824  C  CB  . LYS A 1 126 ? -23.700 -26.508 -36.704 0.41 39.24  ? 389  LYS A CB  1 
ATOM   825  C  CG  . LYS A 1 126 ? -23.197 -27.931 -36.891 0.41 39.36  ? 389  LYS A CG  1 
ATOM   826  C  CD  . LYS A 1 126 ? -24.244 -28.984 -36.600 0.41 39.96  ? 389  LYS A CD  1 
ATOM   827  C  CE  . LYS A 1 126 ? -23.708 -30.388 -36.776 0.41 40.15  ? 389  LYS A CE  1 
ATOM   828  N  NZ  . LYS A 1 126 ? -24.675 -31.404 -36.307 0.41 40.63  ? 389  LYS A NZ  1 
ATOM   829  N  N   . THR A 1 127 ? -26.150 -24.272 -37.121 0.41 38.58  ? 390  THR A N   1 
ATOM   830  C  CA  . THR A 1 127 ? -26.673 -22.940 -36.717 0.41 37.25  ? 390  THR A CA  1 
ATOM   831  C  C   . THR A 1 127 ? -26.838 -22.910 -35.201 0.41 33.02  ? 390  THR A C   1 
ATOM   832  O  O   . THR A 1 127 ? -27.632 -23.655 -34.640 0.41 35.63  ? 390  THR A O   1 
ATOM   833  C  CB  . THR A 1 127 ? -27.963 -22.589 -37.470 0.41 39.48  ? 390  THR A CB  1 
ATOM   834  O  OG1 . THR A 1 127 ? -27.601 -22.385 -38.838 0.41 38.90  ? 390  THR A OG1 1 
ATOM   835  C  CG2 . THR A 1 127 ? -28.644 -21.353 -36.922 0.41 39.23  ? 390  THR A CG2 1 
ATOM   836  N  N   . PRO A 1 128 ? -26.106 -22.013 -34.514 1.00 30.45  ? 391  PRO A N   1 
ATOM   837  C  CA  . PRO A 1 128 ? -26.271 -21.804 -33.088 1.00 33.24  ? 391  PRO A CA  1 
ATOM   838  C  C   . PRO A 1 128 ? -27.732 -21.384 -32.781 1.00 37.66  ? 391  PRO A C   1 
ATOM   839  O  O   . PRO A 1 128 ? -28.347 -20.637 -33.545 1.00 36.95  ? 391  PRO A O   1 
ATOM   840  C  CB  . PRO A 1 128 ? -25.315 -20.642 -32.768 1.00 30.59  ? 391  PRO A CB  1 
ATOM   841  C  CG  . PRO A 1 128 ? -24.421 -20.500 -33.956 1.00 33.10  ? 391  PRO A CG  1 
ATOM   842  C  CD  . PRO A 1 128 ? -25.128 -21.121 -35.140 1.00 31.27  ? 391  PRO A CD  1 
ATOM   843  N  N   . ARG A 1 129 ? -28.261 -21.885 -31.668 0.41 35.72  ? 392  ARG A N   1 
ATOM   844  C  CA  . ARG A 1 129 ? -29.647 -21.616 -31.224 0.41 36.00  ? 392  ARG A CA  1 
ATOM   845  C  C   . ARG A 1 129 ? -29.699 -21.733 -29.700 0.41 41.18  ? 392  ARG A C   1 
ATOM   846  O  O   . ARG A 1 129 ? -28.719 -22.253 -29.108 0.41 34.85  ? 392  ARG A O   1 
ATOM   847  C  CB  . ARG A 1 129 ? -30.622 -22.547 -31.953 0.41 34.86  ? 392  ARG A CB  1 
ATOM   848  C  CG  . ARG A 1 129 ? -30.307 -24.033 -31.858 0.41 34.01  ? 392  ARG A CG  1 
ATOM   849  C  CD  . ARG A 1 129 ? -30.980 -24.692 -30.678 0.41 34.95  ? 392  ARG A CD  1 
ATOM   850  N  NE  . ARG A 1 129 ? -30.783 -26.133 -30.616 0.41 33.60  ? 392  ARG A NE  1 
ATOM   851  C  CZ  . ARG A 1 129 ? -31.451 -26.949 -29.810 0.41 34.10  ? 392  ARG A CZ  1 
ATOM   852  N  NH1 . ARG A 1 129 ? -32.391 -26.474 -29.011 0.41 33.56  ? 392  ARG A NH1 1 
ATOM   853  N  NH2 . ARG A 1 129 ? -31.206 -28.246 -29.827 0.41 34.10  ? 392  ARG A NH2 1 
ATOM   854  N  N   . MET A 1 130 ? -30.774 -21.212 -29.095 1.00 41.00  ? 393  MET A N   1 
ATOM   855  C  CA  . MET A 1 130 ? -31.037 -21.368 -27.655 1.00 43.22  ? 393  MET A CA  1 
ATOM   856  C  C   . MET A 1 130 ? -31.692 -22.705 -27.406 1.00 39.84  ? 393  MET A C   1 
ATOM   857  O  O   . MET A 1 130 ? -32.471 -23.163 -28.231 1.00 41.52  ? 393  MET A O   1 
ATOM   858  C  CB  . MET A 1 130 ? -31.942 -20.261 -27.125 1.00 51.40  ? 393  MET A CB  1 
ATOM   859  C  CG  . MET A 1 130 ? -31.253 -18.913 -27.162 1.00 59.00  ? 393  MET A CG  1 
ATOM   860  S  SD  . MET A 1 130 ? -32.208 -17.561 -26.378 1.00 69.80  ? 393  MET A SD  1 
ATOM   861  C  CE  . MET A 1 130 ? -33.445 -17.294 -27.650 1.00 69.12  ? 393  MET A CE  1 
ATOM   862  N  N   . CYS A 1 131 ? -31.340 -23.331 -26.296 1.00 37.30  ? 394  CYS A N   1 
ATOM   863  C  CA  . CYS A 1 131 ? -32.014 -24.544 -25.826 1.00 40.20  ? 394  CYS A CA  1 
ATOM   864  C  C   . CYS A 1 131 ? -33.182 -24.095 -24.922 1.00 42.47  ? 394  CYS A C   1 
ATOM   865  O  O   . CYS A 1 131 ? -33.178 -22.938 -24.447 1.00 44.82  ? 394  CYS A O   1 
ATOM   866  C  CB  . CYS A 1 131 ? -31.036 -25.474 -25.140 1.00 39.93  ? 394  CYS A CB  1 
ATOM   867  S  SG  . CYS A 1 131 ? -29.867 -26.278 -26.272 1.00 39.91  ? 394  CYS A SG  1 
ATOM   868  N  N   . THR A 1 132 ? -34.206 -24.921 -24.765 1.00 45.83  ? 395  THR A N   1 
ATOM   869  C  CA  . THR A 1 132 ? -35.524 -24.437 -24.244 1.00 46.91  ? 395  THR A CA  1 
ATOM   870  C  C   . THR A 1 132 ? -35.762 -24.967 -22.838 1.00 43.66  ? 395  THR A C   1 
ATOM   871  O  O   . THR A 1 132 ? -35.226 -26.027 -22.510 1.00 43.33  ? 395  THR A O   1 
ATOM   872  C  CB  . THR A 1 132 ? -36.633 -24.885 -25.191 1.00 44.81  ? 395  THR A CB  1 
ATOM   873  O  OG1 . THR A 1 132 ? -36.588 -26.311 -25.289 1.00 51.54  ? 395  THR A OG1 1 
ATOM   874  C  CG2 . THR A 1 132 ? -36.483 -24.273 -26.563 1.00 54.80  ? 395  THR A CG2 1 
ATOM   875  N  N   . ARG A 1 133 ? -36.633 -24.308 -22.081 1.00 51.17  ? 396  ARG A N   1 
ATOM   876  C  CA  . ARG A 1 133 ? -37.161 -24.825 -20.780 1.00 47.42  ? 396  ARG A CA  1 
ATOM   877  C  C   . ARG A 1 133 ? -37.636 -26.259 -20.981 1.00 52.12  ? 396  ARG A C   1 
ATOM   878  O  O   . ARG A 1 133 ? -37.319 -27.157 -20.152 1.00 54.77  ? 396  ARG A O   1 
ATOM   879  C  CB  . ARG A 1 133 ? -38.259 -23.904 -20.236 1.00 51.24  ? 396  ARG A CB  1 
ATOM   880  C  CG  . ARG A 1 133 ? -37.801 -22.463 -20.123 1.00 54.61  ? 396  ARG A CG  1 
ATOM   881  C  CD  . ARG A 1 133 ? -38.676 -21.510 -19.346 1.00 62.58  ? 396  ARG A CD  1 
ATOM   882  N  NE  . ARG A 1 133 ? -37.953 -20.269 -19.103 1.00 60.57  ? 396  ARG A NE  1 
ATOM   883  C  CZ  . ARG A 1 133 ? -38.377 -19.288 -18.311 1.00 72.73  ? 396  ARG A CZ  1 
ATOM   884  N  NH1 . ARG A 1 133 ? -39.576 -19.352 -17.747 1.00 77.44  ? 396  ARG A NH1 1 
ATOM   885  N  NH2 . ARG A 1 133 ? -37.613 -18.228 -18.122 1.00 65.32  ? 396  ARG A NH2 1 
ATOM   886  N  N   . GLU A 1 134 ? -38.343 -26.515 -22.081 0.41 55.48  ? 397  GLU A N   1 
ATOM   887  C  CA  . GLU A 1 134 ? -38.942 -27.846 -22.367 0.41 59.52  ? 397  GLU A CA  1 
ATOM   888  C  C   . GLU A 1 134 ? -37.816 -28.871 -22.535 0.41 57.32  ? 397  GLU A C   1 
ATOM   889  O  O   . GLU A 1 134 ? -37.934 -29.963 -21.952 0.41 59.96  ? 397  GLU A O   1 
ATOM   890  C  CB  . GLU A 1 134 ? -39.869 -27.778 -23.582 0.41 66.47  ? 397  GLU A CB  1 
ATOM   891  C  CG  . GLU A 1 134 ? -41.195 -27.094 -23.286 0.41 73.16  ? 397  GLU A CG  1 
ATOM   892  C  CD  . GLU A 1 134 ? -41.095 -25.682 -22.724 0.41 77.27  ? 397  GLU A CD  1 
ATOM   893  O  OE1 . GLU A 1 134 ? -40.191 -24.928 -23.170 0.41 77.31  ? 397  GLU A OE1 1 
ATOM   894  O  OE2 . GLU A 1 134 ? -41.917 -25.333 -21.839 0.41 74.65  ? 397  GLU A OE2 1 
ATOM   895  N  N   . GLU A 1 135 ? -36.756 -28.535 -23.282 1.00 58.33  ? 398  GLU A N   1 
ATOM   896  C  CA  . GLU A 1 135 ? -35.581 -29.451 -23.425 1.00 56.45  ? 398  GLU A CA  1 
ATOM   897  C  C   . GLU A 1 135 ? -34.928 -29.710 -22.063 1.00 53.26  ? 398  GLU A C   1 
ATOM   898  O  O   . GLU A 1 135 ? -34.558 -30.859 -21.771 1.00 52.07  ? 398  GLU A O   1 
ATOM   899  C  CB  . GLU A 1 135 ? -34.483 -28.921 -24.355 1.00 53.28  ? 398  GLU A CB  1 
ATOM   900  C  CG  . GLU A 1 135 ? -34.838 -29.091 -25.808 1.00 55.60  ? 398  GLU A CG  1 
ATOM   901  C  CD  . GLU A 1 135 ? -33.866 -28.417 -26.750 1.00 54.82  ? 398  GLU A CD  1 
ATOM   902  O  OE1 . GLU A 1 135 ? -33.600 -27.193 -26.539 1.00 40.57  ? 398  GLU A OE1 1 
ATOM   903  O  OE2 . GLU A 1 135 ? -33.373 -29.136 -27.684 1.00 56.62  ? 398  GLU A OE2 1 
ATOM   904  N  N   . PHE A 1 136 ? -34.774 -28.654 -21.260 0.41 53.18  ? 399  PHE A N   1 
ATOM   905  C  CA  . PHE A 1 136 ? -34.108 -28.699 -19.932 0.41 56.39  ? 399  PHE A CA  1 
ATOM   906  C  C   . PHE A 1 136 ? -34.902 -29.615 -18.988 0.41 59.67  ? 399  PHE A C   1 
ATOM   907  O  O   . PHE A 1 136 ? -34.292 -30.514 -18.362 0.41 57.97  ? 399  PHE A O   1 
ATOM   908  C  CB  . PHE A 1 136 ? -33.950 -27.285 -19.369 0.41 55.78  ? 399  PHE A CB  1 
ATOM   909  C  CG  . PHE A 1 136 ? -33.157 -27.212 -18.089 0.41 56.60  ? 399  PHE A CG  1 
ATOM   910  C  CD1 . PHE A 1 136 ? -31.841 -27.645 -18.048 0.41 53.00  ? 399  PHE A CD1 1 
ATOM   911  C  CD2 . PHE A 1 136 ? -33.721 -26.701 -16.929 0.41 55.71  ? 399  PHE A CD2 1 
ATOM   912  C  CE1 . PHE A 1 136 ? -31.107 -27.568 -16.876 0.41 54.20  ? 399  PHE A CE1 1 
ATOM   913  C  CE2 . PHE A 1 136 ? -32.985 -26.622 -15.758 0.41 55.57  ? 399  PHE A CE2 1 
ATOM   914  C  CZ  . PHE A 1 136 ? -31.679 -27.056 -15.734 0.41 56.36  ? 399  PHE A CZ  1 
ATOM   915  N  N   . THR A 1 137 ? -36.221 -29.405 -18.905 0.41 60.39  ? 400  THR A N   1 
ATOM   916  C  CA  . THR A 1 137 ? -37.153 -30.175 -18.034 0.41 61.68  ? 400  THR A CA  1 
ATOM   917  C  C   . THR A 1 137 ? -37.102 -31.658 -18.414 0.41 63.34  ? 400  THR A C   1 
ATOM   918  O  O   . THR A 1 137 ? -37.155 -32.492 -17.502 0.41 62.42  ? 400  THR A O   1 
ATOM   919  C  CB  . THR A 1 137 ? -38.572 -29.597 -18.097 0.41 59.60  ? 400  THR A CB  1 
ATOM   920  O  OG1 . THR A 1 137 ? -38.504 -28.313 -17.478 0.41 58.82  ? 400  THR A OG1 1 
ATOM   921  C  CG2 . THR A 1 137 ? -39.610 -30.451 -17.402 0.41 60.06  ? 400  THR A CG2 1 
ATOM   922  N  N   . ARG A 1 138 ? -36.998 -31.972 -19.707 0.41 68.24  ? 401  ARG A N   1 
ATOM   923  C  CA  . ARG A 1 138 ? -36.920 -33.374 -20.198 0.41 73.82  ? 401  ARG A CA  1 
ATOM   924  C  C   . ARG A 1 138 ? -35.641 -34.020 -19.652 0.41 75.71  ? 401  ARG A C   1 
ATOM   925  O  O   . ARG A 1 138 ? -35.674 -35.225 -19.352 0.41 77.82  ? 401  ARG A O   1 
ATOM   926  C  CB  . ARG A 1 138 ? -36.976 -33.415 -21.728 0.41 79.94  ? 401  ARG A CB  1 
ATOM   927  C  CG  . ARG A 1 138 ? -37.211 -34.803 -22.308 0.41 82.99  ? 401  ARG A CG  1 
ATOM   928  C  CD  . ARG A 1 138 ? -38.095 -34.772 -23.544 0.41 86.34  ? 401  ARG A CD  1 
ATOM   929  N  NE  . ARG A 1 138 ? -37.591 -33.854 -24.560 0.41 88.58  ? 401  ARG A NE  1 
ATOM   930  C  CZ  . ARG A 1 138 ? -36.631 -34.129 -25.444 0.41 88.31  ? 401  ARG A CZ  1 
ATOM   931  N  NH1 . ARG A 1 138 ? -36.043 -35.315 -25.461 0.41 89.68  ? 401  ARG A NH1 1 
ATOM   932  N  NH2 . ARG A 1 138 ? -36.258 -33.203 -26.312 0.41 83.70  ? 401  ARG A NH2 1 
ATOM   933  N  N   . LYS A 1 139 ? -34.565 -33.241 -19.507 0.41 79.30  ? 402  LYS A N   1 
ATOM   934  C  CA  . LYS A 1 139 ? -33.260 -33.718 -18.976 0.41 83.86  ? 402  LYS A CA  1 
ATOM   935  C  C   . LYS A 1 139 ? -33.391 -34.020 -17.477 0.41 87.20  ? 402  LYS A C   1 
ATOM   936  O  O   . LYS A 1 139 ? -32.759 -34.998 -17.025 0.41 86.63  ? 402  LYS A O   1 
ATOM   937  C  CB  . LYS A 1 139 ? -32.148 -32.697 -19.239 0.41 83.98  ? 402  LYS A CB  1 
ATOM   938  C  CG  . LYS A 1 139 ? -31.909 -32.369 -20.706 0.41 86.73  ? 402  LYS A CG  1 
ATOM   939  C  CD  . LYS A 1 139 ? -30.787 -31.377 -20.943 0.41 87.88  ? 402  LYS A CD  1 
ATOM   940  C  CE  . LYS A 1 139 ? -29.408 -31.998 -20.875 0.41 89.96  ? 402  LYS A CE  1 
ATOM   941  N  NZ  . LYS A 1 139 ? -29.175 -32.943 -21.994 0.41 90.69  ? 402  LYS A NZ  1 
ATOM   942  N  N   . VAL A 1 140 ? -34.173 -33.227 -16.732 0.41 89.77  ? 403  VAL A N   1 
ATOM   943  C  CA  . VAL A 1 140 ? -34.325 -33.386 -15.252 0.41 95.83  ? 403  VAL A CA  1 
ATOM   944  C  C   . VAL A 1 140 ? -35.304 -34.537 -14.976 0.41 100.51 ? 403  VAL A C   1 
ATOM   945  O  O   . VAL A 1 140 ? -35.071 -35.272 -13.994 0.41 102.33 ? 403  VAL A O   1 
ATOM   946  C  CB  . VAL A 1 140 ? -34.742 -32.082 -14.535 0.41 96.37  ? 403  VAL A CB  1 
ATOM   947  C  CG1 . VAL A 1 140 ? -34.037 -30.861 -15.104 0.41 95.50  ? 403  VAL A CG1 1 
ATOM   948  C  CG2 . VAL A 1 140 ? -36.245 -31.859 -14.521 0.41 97.88  ? 403  VAL A CG2 1 
ATOM   949  N  N   . ARG A 1 141 ? -36.344 -34.692 -15.808 0.41 102.16 ? 404  ARG A N   1 
ATOM   950  C  CA  . ARG A 1 141 ? -37.359 -35.776 -15.683 0.41 103.60 ? 404  ARG A CA  1 
ATOM   951  C  C   . ARG A 1 141 ? -36.726 -37.126 -16.046 0.41 104.07 ? 404  ARG A C   1 
ATOM   952  O  O   . ARG A 1 141 ? -37.184 -38.149 -15.504 0.41 108.00 ? 404  ARG A O   1 
ATOM   953  C  CB  . ARG A 1 141 ? -38.583 -35.503 -16.563 0.41 104.60 ? 404  ARG A CB  1 
ATOM   954  C  CG  . ARG A 1 141 ? -39.424 -34.314 -16.118 0.41 110.15 ? 404  ARG A CG  1 
ATOM   955  C  CD  . ARG A 1 141 ? -40.901 -34.638 -15.956 0.41 115.48 ? 404  ARG A CD  1 
ATOM   956  N  NE  . ARG A 1 141 ? -41.773 -33.615 -16.526 0.41 121.12 ? 404  ARG A NE  1 
ATOM   957  C  CZ  . ARG A 1 141 ? -42.027 -32.421 -15.989 0.41 122.34 ? 404  ARG A CZ  1 
ATOM   958  N  NH1 . ARG A 1 141 ? -41.469 -32.058 -14.844 0.41 121.87 ? 404  ARG A NH1 1 
ATOM   959  N  NH2 . ARG A 1 141 ? -42.842 -31.584 -16.610 0.41 122.75 ? 404  ARG A NH2 1 
ATOM   960  N  N   . SER A 1 142 ? -35.716 -37.127 -16.923 0.41 105.36 ? 405  SER A N   1 
ATOM   961  C  CA  . SER A 1 142 ? -34.975 -38.335 -17.376 0.41 106.67 ? 405  SER A CA  1 
ATOM   962  C  C   . SER A 1 142 ? -33.727 -38.561 -16.509 0.41 106.47 ? 405  SER A C   1 
ATOM   963  O  O   . SER A 1 142 ? -32.956 -39.491 -16.824 0.41 107.89 ? 405  SER A O   1 
ATOM   964  C  CB  . SER A 1 142 ? -34.621 -38.228 -18.840 0.41 107.93 ? 405  SER A CB  1 
ATOM   965  O  OG  . SER A 1 142 ? -33.805 -37.092 -19.083 0.41 108.14 ? 405  SER A OG  1 
ATOM   966  N  N   . ASN A 1 143 ? -33.532 -37.738 -15.469 0.41 105.13 ? 406  ASN A N   1 
ATOM   967  C  CA  . ASN A 1 143 ? -32.462 -37.881 -14.443 0.41 106.53 ? 406  ASN A CA  1 
ATOM   968  C  C   . ASN A 1 143 ? -31.081 -37.803 -15.110 0.41 105.68 ? 406  ASN A C   1 
ATOM   969  O  O   . ASN A 1 143 ? -30.300 -38.768 -14.976 0.41 108.98 ? 406  ASN A O   1 
ATOM   970  C  CB  . ASN A 1 143 ? -32.617 -39.177 -13.638 0.41 107.72 ? 406  ASN A CB  1 
ATOM   971  C  CG  . ASN A 1 143 ? -33.959 -39.298 -12.947 0.41 106.55 ? 406  ASN A CG  1 
ATOM   972  O  OD1 . ASN A 1 143 ? -34.931 -38.659 -13.344 0.41 104.30 ? 406  ASN A OD1 1 
ATOM   973  N  ND2 . ASN A 1 143 ? -34.027 -40.128 -11.919 0.41 107.36 ? 406  ASN A ND2 1 
ATOM   974  N  N   . ALA A 1 144 ? -30.794 -36.693 -15.796 0.41 103.96 ? 407  ALA A N   1 
ATOM   975  C  CA  . ALA A 1 144 ? -29.468 -36.373 -16.375 0.41 106.18 ? 407  ALA A CA  1 
ATOM   976  C  C   . ALA A 1 144 ? -28.661 -35.565 -15.352 0.41 108.51 ? 407  ALA A C   1 
ATOM   977  O  O   . ALA A 1 144 ? -29.276 -34.777 -14.601 0.41 106.40 ? 407  ALA A O   1 
ATOM   978  C  CB  . ALA A 1 144 ? -29.630 -35.623 -17.676 0.41 104.95 ? 407  ALA A CB  1 
ATOM   979  N  N   . ALA A 1 145 ? -27.339 -35.767 -15.319 0.41 106.93 ? 408  ALA A N   1 
ATOM   980  C  CA  . ALA A 1 145 ? -26.390 -35.059 -14.428 0.41 103.44 ? 408  ALA A CA  1 
ATOM   981  C  C   . ALA A 1 145 ? -26.169 -33.633 -14.952 0.41 103.39 ? 408  ALA A C   1 
ATOM   982  O  O   . ALA A 1 145 ? -25.560 -33.488 -16.032 0.41 100.65 ? 408  ALA A O   1 
ATOM   983  C  CB  . ALA A 1 145 ? -25.095 -35.832 -14.332 0.41 101.62 ? 408  ALA A CB  1 
ATOM   984  N  N   . LEU A 1 146 ? -26.673 -32.630 -14.222 0.41 103.60 ? 409  LEU A N   1 
ATOM   985  C  CA  . LEU A 1 146 ? -26.576 -31.182 -14.566 0.41 102.47 ? 409  LEU A CA  1 
ATOM   986  C  C   . LEU A 1 146 ? -25.587 -30.471 -13.633 0.41 100.24 ? 409  LEU A C   1 
ATOM   987  O  O   . LEU A 1 146 ? -25.083 -29.403 -14.028 0.41 98.47  ? 409  LEU A O   1 
ATOM   988  C  CB  . LEU A 1 146 ? -27.967 -30.552 -14.459 0.41 101.60 ? 409  LEU A CB  1 
ATOM   989  C  CG  . LEU A 1 146 ? -29.007 -31.090 -15.440 0.41 103.24 ? 409  LEU A CG  1 
ATOM   990  C  CD1 . LEU A 1 146 ? -30.406 -30.677 -15.019 0.41 104.12 ? 409  LEU A CD1 1 
ATOM   991  C  CD2 . LEU A 1 146 ? -28.718 -30.626 -16.861 0.41 100.89 ? 409  LEU A CD2 1 
ATOM   992  N  N   . GLY A 1 147 ? -25.330 -31.031 -12.446 0.41 98.61  ? 410  GLY A N   1 
ATOM   993  C  CA  . GLY A 1 147 ? -24.444 -30.440 -11.424 0.41 97.58  ? 410  GLY A CA  1 
ATOM   994  C  C   . GLY A 1 147 ? -25.165 -29.382 -10.607 0.41 97.28  ? 410  GLY A C   1 
ATOM   995  O  O   . GLY A 1 147 ? -24.584 -28.299 -10.398 0.41 90.59  ? 410  GLY A O   1 
ATOM   996  N  N   . ALA A 1 148 ? -26.388 -29.690 -10.160 0.41 99.69  ? 411  ALA A N   1 
ATOM   997  C  CA  . ALA A 1 148 ? -27.253 -28.806 -9.343  0.41 101.81 ? 411  ALA A CA  1 
ATOM   998  C  C   . ALA A 1 148 ? -26.866 -28.929 -7.862  0.41 105.48 ? 411  ALA A C   1 
ATOM   999  O  O   . ALA A 1 148 ? -26.012 -29.785 -7.543  0.41 102.27 ? 411  ALA A O   1 
ATOM   1000 C  CB  . ALA A 1 148 ? -28.704 -29.154 -9.570  0.41 100.23 ? 411  ALA A CB  1 
ATOM   1001 N  N   . ILE A 1 149 ? -27.471 -28.099 -7.002  0.41 110.13 ? 412  ILE A N   1 
ATOM   1002 C  CA  . ILE A 1 149 ? -27.249 -28.079 -5.522  0.41 111.30 ? 412  ILE A CA  1 
ATOM   1003 C  C   . ILE A 1 149 ? -28.608 -28.128 -4.811  0.41 113.66 ? 412  ILE A C   1 
ATOM   1004 O  O   . ILE A 1 149 ? -29.542 -27.463 -5.303  0.41 118.22 ? 412  ILE A O   1 
ATOM   1005 C  CB  . ILE A 1 149 ? -26.410 -26.854 -5.093  0.41 111.40 ? 412  ILE A CB  1 
ATOM   1006 C  CG1 . ILE A 1 149 ? -27.112 -25.521 -5.378  0.41 113.07 ? 412  ILE A CG1 1 
ATOM   1007 C  CG2 . ILE A 1 149 ? -25.027 -26.906 -5.723  0.41 111.36 ? 412  ILE A CG2 1 
ATOM   1008 C  CD1 . ILE A 1 149 ? -27.795 -24.905 -4.174  0.41 113.32 ? 412  ILE A CD1 1 
ATOM   1009 N  N   . TRP A 1 156 ? -37.386 -27.016 -2.748  0.41 64.12  ? 419  TRP A N   1 
ATOM   1010 C  CA  . TRP A 1 156 ? -37.057 -28.071 -3.745  0.41 65.30  ? 419  TRP A CA  1 
ATOM   1011 C  C   . TRP A 1 156 ? -35.815 -28.843 -3.286  0.41 69.47  ? 419  TRP A C   1 
ATOM   1012 O  O   . TRP A 1 156 ? -34.713 -28.257 -3.300  0.41 68.94  ? 419  TRP A O   1 
ATOM   1013 C  CB  . TRP A 1 156 ? -36.866 -27.466 -5.146  0.41 63.25  ? 419  TRP A CB  1 
ATOM   1014 C  CG  . TRP A 1 156 ? -37.867 -26.401 -5.474  0.41 58.39  ? 419  TRP A CG  1 
ATOM   1015 C  CD1 . TRP A 1 156 ? -39.222 -26.542 -5.515  0.41 57.21  ? 419  TRP A CD1 1 
ATOM   1016 C  CD2 . TRP A 1 156 ? -37.597 -25.017 -5.765  0.41 55.45  ? 419  TRP A CD2 1 
ATOM   1017 N  NE1 . TRP A 1 156 ? -39.814 -25.348 -5.821  0.41 56.92  ? 419  TRP A NE1 1 
ATOM   1018 C  CE2 . TRP A 1 156 ? -38.843 -24.394 -5.985  0.41 54.72  ? 419  TRP A CE2 1 
ATOM   1019 C  CE3 . TRP A 1 156 ? -36.432 -24.250 -5.871  0.41 53.77  ? 419  TRP A CE3 1 
ATOM   1020 C  CZ2 . TRP A 1 156 ? -38.951 -23.041 -6.305  0.41 54.98  ? 419  TRP A CZ2 1 
ATOM   1021 C  CZ3 . TRP A 1 156 ? -36.538 -22.914 -6.188  0.41 53.30  ? 419  TRP A CZ3 1 
ATOM   1022 C  CH2 . TRP A 1 156 ? -37.781 -22.318 -6.397  0.41 55.48  ? 419  TRP A CH2 1 
ATOM   1023 N  N   . LYS A 1 157 ? -36.003 -30.103 -2.877  0.41 77.62  ? 420  LYS A N   1 
ATOM   1024 C  CA  . LYS A 1 157 ? -34.915 -31.054 -2.511  0.41 79.77  ? 420  LYS A CA  1 
ATOM   1025 C  C   . LYS A 1 157 ? -34.439 -31.790 -3.772  0.41 80.95  ? 420  LYS A C   1 
ATOM   1026 O  O   . LYS A 1 157 ? -33.343 -32.394 -3.722  0.41 82.96  ? 420  LYS A O   1 
ATOM   1027 C  CB  . LYS A 1 157 ? -35.388 -32.023 -1.417  0.41 81.14  ? 420  LYS A CB  1 
ATOM   1028 C  CG  . LYS A 1 157 ? -36.174 -33.247 -1.879  0.41 82.57  ? 420  LYS A CG  1 
ATOM   1029 C  CD  . LYS A 1 157 ? -37.596 -32.954 -2.325  0.41 83.97  ? 420  LYS A CD  1 
ATOM   1030 C  CE  . LYS A 1 157 ? -38.465 -34.193 -2.415  0.41 82.79  ? 420  LYS A CE  1 
ATOM   1031 N  NZ  . LYS A 1 157 ? -38.785 -34.752 -1.079  0.41 79.40  ? 420  LYS A NZ  1 
ATOM   1032 N  N   . SER A 1 158 ? -35.232 -31.737 -4.852  0.41 76.76  ? 421  SER A N   1 
ATOM   1033 C  CA  . SER A 1 158 ? -34.970 -32.409 -6.152  0.41 74.53  ? 421  SER A CA  1 
ATOM   1034 C  C   . SER A 1 158 ? -35.163 -31.422 -7.310  0.41 72.79  ? 421  SER A C   1 
ATOM   1035 O  O   . SER A 1 158 ? -35.931 -30.448 -7.147  0.41 67.47  ? 421  SER A O   1 
ATOM   1036 C  CB  . SER A 1 158 ? -35.855 -33.617 -6.320  0.41 73.06  ? 421  SER A CB  1 
ATOM   1037 O  OG  . SER A 1 158 ? -37.225 -33.243 -6.332  0.41 77.04  ? 421  SER A OG  1 
ATOM   1038 N  N   . ALA A 1 159 ? -34.494 -31.690 -8.437  0.41 70.91  ? 422  ALA A N   1 
ATOM   1039 C  CA  . ALA A 1 159 ? -34.581 -30.923 -9.702  0.41 68.03  ? 422  ALA A CA  1 
ATOM   1040 C  C   . ALA A 1 159 ? -36.017 -30.964 -10.240 0.41 64.13  ? 422  ALA A C   1 
ATOM   1041 O  O   . ALA A 1 159 ? -36.513 -29.913 -10.684 0.41 57.42  ? 422  ALA A O   1 
ATOM   1042 C  CB  . ALA A 1 159 ? -33.604 -31.486 -10.705 0.41 70.21  ? 422  ALA A CB  1 
ATOM   1043 N  N   . ARG A 1 160 ? -36.658 -32.136 -10.177 0.41 64.01  ? 423  ARG A N   1 
ATOM   1044 C  CA  . ARG A 1 160 ? -38.045 -32.371 -10.662 0.41 66.87  ? 423  ARG A CA  1 
ATOM   1045 C  C   . ARG A 1 160 ? -39.009 -31.358 -10.021 0.41 67.95  ? 423  ARG A C   1 
ATOM   1046 O  O   . ARG A 1 160 ? -39.862 -30.812 -10.754 0.41 61.92  ? 423  ARG A O   1 
ATOM   1047 C  CB  . ARG A 1 160 ? -38.470 -33.813 -10.362 0.41 69.43  ? 423  ARG A CB  1 
ATOM   1048 C  CG  . ARG A 1 160 ? -37.713 -34.874 -11.150 0.41 72.77  ? 423  ARG A CG  1 
ATOM   1049 C  CD  . ARG A 1 160 ? -37.763 -36.236 -10.476 0.41 74.89  ? 423  ARG A CD  1 
ATOM   1050 N  NE  . ARG A 1 160 ? -37.308 -37.331 -11.325 0.41 75.31  ? 423  ARG A NE  1 
ATOM   1051 C  CZ  . ARG A 1 160 ? -38.006 -37.872 -12.326 0.41 77.58  ? 423  ARG A CZ  1 
ATOM   1052 N  NH1 . ARG A 1 160 ? -37.487 -38.872 -13.020 0.41 78.04  ? 423  ARG A NH1 1 
ATOM   1053 N  NH2 . ARG A 1 160 ? -39.209 -37.417 -12.643 0.41 74.74  ? 423  ARG A NH2 1 
ATOM   1054 N  N   . GLU A 1 161 ? -38.871 -31.103 -8.713  0.41 66.86  ? 424  GLU A N   1 
ATOM   1055 C  CA  . GLU A 1 161 ? -39.793 -30.242 -7.915  0.41 65.14  ? 424  GLU A CA  1 
ATOM   1056 C  C   . GLU A 1 161 ? -39.638 -28.771 -8.331  0.41 62.27  ? 424  GLU A C   1 
ATOM   1057 O  O   . GLU A 1 161 ? -40.648 -28.041 -8.291  0.41 60.63  ? 424  GLU A O   1 
ATOM   1058 C  CB  . GLU A 1 161 ? -39.529 -30.419 -6.417  0.41 65.94  ? 424  GLU A CB  1 
ATOM   1059 C  CG  . GLU A 1 161 ? -40.691 -29.998 -5.532  0.41 66.48  ? 424  GLU A CG  1 
ATOM   1060 C  CD  . GLU A 1 161 ? -40.382 -29.953 -4.042  0.41 66.36  ? 424  GLU A CD  1 
ATOM   1061 O  OE1 . GLU A 1 161 ? -39.301 -30.442 -3.639  0.41 61.42  ? 424  GLU A OE1 1 
ATOM   1062 O  OE2 . GLU A 1 161 ? -41.227 -29.432 -3.284  0.41 64.04  ? 424  GLU A OE2 1 
ATOM   1063 N  N   . ALA A 1 162 ? -38.423 -28.354 -8.707  0.41 59.05  ? 425  ALA A N   1 
ATOM   1064 C  CA  . ALA A 1 162 ? -38.080 -26.960 -9.080  0.41 57.41  ? 425  ALA A CA  1 
ATOM   1065 C  C   . ALA A 1 162 ? -38.663 -26.617 -10.458 0.41 55.24  ? 425  ALA A C   1 
ATOM   1066 O  O   . ALA A 1 162 ? -39.241 -25.520 -10.596 0.41 53.01  ? 425  ALA A O   1 
ATOM   1067 C  CB  . ALA A 1 162 ? -36.580 -26.770 -9.051  0.41 58.22  ? 425  ALA A CB  1 
ATOM   1068 N  N   . VAL A 1 163 ? -38.527 -27.519 -11.437 0.41 55.49  ? 426  VAL A N   1 
ATOM   1069 C  CA  . VAL A 1 163 ? -38.965 -27.295 -12.852 0.41 57.84  ? 426  VAL A CA  1 
ATOM   1070 C  C   . VAL A 1 163 ? -40.495 -27.370 -12.944 0.41 59.96  ? 426  VAL A C   1 
ATOM   1071 O  O   . VAL A 1 163 ? -41.032 -26.939 -13.978 0.41 58.97  ? 426  VAL A O   1 
ATOM   1072 C  CB  . VAL A 1 163 ? -38.299 -28.280 -13.836 0.41 55.34  ? 426  VAL A CB  1 
ATOM   1073 C  CG1 . VAL A 1 163 ? -36.782 -28.154 -13.814 0.41 56.44  ? 426  VAL A CG1 1 
ATOM   1074 C  CG2 . VAL A 1 163 ? -38.720 -29.724 -13.597 0.41 51.75  ? 426  VAL A CG2 1 
ATOM   1075 N  N   . GLU A 1 164 ? -41.162 -27.909 -11.916 0.41 67.31  ? 427  GLU A N   1 
ATOM   1076 C  CA  . GLU A 1 164 ? -42.647 -27.991 -11.820 0.41 71.30  ? 427  GLU A CA  1 
ATOM   1077 C  C   . GLU A 1 164 ? -43.199 -26.754 -11.091 0.41 71.70  ? 427  GLU A C   1 
ATOM   1078 O  O   . GLU A 1 164 ? -44.403 -26.461 -11.267 0.41 78.03  ? 427  GLU A O   1 
ATOM   1079 C  CB  . GLU A 1 164 ? -43.052 -29.302 -11.143 0.41 71.91  ? 427  GLU A CB  1 
ATOM   1080 C  CG  . GLU A 1 164 ? -42.778 -30.522 -12.010 0.41 74.33  ? 427  GLU A CG  1 
ATOM   1081 C  CD  . GLU A 1 164 ? -42.963 -31.876 -11.341 0.41 79.62  ? 427  GLU A CD  1 
ATOM   1082 O  OE1 . GLU A 1 164 ? -43.388 -31.909 -10.167 0.41 83.40  ? 427  GLU A OE1 1 
ATOM   1083 O  OE2 . GLU A 1 164 ? -42.685 -32.902 -12.002 0.41 80.71  ? 427  GLU A OE2 1 
ATOM   1084 N  N   . ASP A 1 165 ? -42.354 -26.040 -10.334 0.41 67.74  ? 428  ASP A N   1 
ATOM   1085 C  CA  . ASP A 1 165 ? -42.727 -24.825 -9.557  0.41 65.30  ? 428  ASP A CA  1 
ATOM   1086 C  C   . ASP A 1 165 ? -42.437 -23.560 -10.376 0.41 62.81  ? 428  ASP A C   1 
ATOM   1087 O  O   . ASP A 1 165 ? -41.249 -23.240 -10.581 0.41 60.02  ? 428  ASP A O   1 
ATOM   1088 C  CB  . ASP A 1 165 ? -41.994 -24.772 -8.213  0.41 64.79  ? 428  ASP A CB  1 
ATOM   1089 C  CG  . ASP A 1 165 ? -42.427 -23.614 -7.328  0.41 63.77  ? 428  ASP A CG  1 
ATOM   1090 O  OD1 . ASP A 1 165 ? -42.736 -22.539 -7.877  0.41 59.39  ? 428  ASP A OD1 1 
ATOM   1091 O  OD2 . ASP A 1 165 ? -42.457 -23.801 -6.093  0.41 64.32  ? 428  ASP A OD2 1 
ATOM   1092 N  N   . SER A 1 166 ? -43.497 -22.838 -10.753 0.41 62.19  ? 429  SER A N   1 
ATOM   1093 C  CA  . SER A 1 166 ? -43.471 -21.591 -11.564 0.41 58.56  ? 429  SER A CA  1 
ATOM   1094 C  C   . SER A 1 166 ? -42.688 -20.486 -10.848 0.41 56.41  ? 429  SER A C   1 
ATOM   1095 O  O   . SER A 1 166 ? -42.256 -19.539 -11.533 0.41 55.45  ? 429  SER A O   1 
ATOM   1096 C  CB  . SER A 1 166 ? -44.877 -21.145 -11.871 0.41 62.60  ? 429  SER A CB  1 
ATOM   1097 O  OG  . SER A 1 166 ? -45.720 -22.269 -12.082 0.41 65.26  ? 429  SER A OG  1 
ATOM   1098 N  N   . GLY A 1 167 ? -42.552 -20.573 -9.520  0.41 58.16  ? 430  GLY A N   1 
ATOM   1099 C  CA  . GLY A 1 167 ? -41.769 -19.625 -8.703  0.41 56.67  ? 430  GLY A CA  1 
ATOM   1100 C  C   . GLY A 1 167 ? -40.325 -19.572 -9.167  0.41 57.49  ? 430  GLY A C   1 
ATOM   1101 O  O   . GLY A 1 167 ? -39.844 -18.471 -9.471  0.41 54.88  ? 430  GLY A O   1 
ATOM   1102 N  N   . PHE A 1 168 ? -39.674 -20.737 -9.242  0.41 57.67  ? 431  PHE A N   1 
ATOM   1103 C  CA  . PHE A 1 168 ? -38.291 -20.930 -9.756  0.41 57.90  ? 431  PHE A CA  1 
ATOM   1104 C  C   . PHE A 1 168 ? -38.091 -20.134 -11.053 0.41 56.83  ? 431  PHE A C   1 
ATOM   1105 O  O   . PHE A 1 168 ? -37.179 -19.287 -11.117 0.41 55.28  ? 431  PHE A O   1 
ATOM   1106 C  CB  . PHE A 1 168 ? -38.018 -22.418 -9.986  0.41 59.01  ? 431  PHE A CB  1 
ATOM   1107 C  CG  . PHE A 1 168 ? -36.802 -22.707 -10.824 0.41 57.50  ? 431  PHE A CG  1 
ATOM   1108 C  CD1 . PHE A 1 168 ? -35.531 -22.485 -10.321 0.41 58.03  ? 431  PHE A CD1 1 
ATOM   1109 C  CD2 . PHE A 1 168 ? -36.929 -23.196 -12.116 0.41 59.15  ? 431  PHE A CD2 1 
ATOM   1110 C  CE1 . PHE A 1 168 ? -34.409 -22.745 -11.092 0.41 58.59  ? 431  PHE A CE1 1 
ATOM   1111 C  CE2 . PHE A 1 168 ? -35.807 -23.461 -12.886 0.41 59.22  ? 431  PHE A CE2 1 
ATOM   1112 C  CZ  . PHE A 1 168 ? -34.550 -23.235 -12.371 0.41 60.11  ? 431  PHE A CZ  1 
ATOM   1113 N  N   . TRP A 1 169 ? -38.938 -20.378 -12.057 0.41 57.63  ? 432  TRP A N   1 
ATOM   1114 C  CA  . TRP A 1 169 ? -38.819 -19.758 -13.406 0.41 54.32  ? 432  TRP A CA  1 
ATOM   1115 C  C   . TRP A 1 169 ? -38.891 -18.226 -13.292 0.41 57.10  ? 432  TRP A C   1 
ATOM   1116 O  O   . TRP A 1 169 ? -38.334 -17.550 -14.179 0.41 53.98  ? 432  TRP A O   1 
ATOM   1117 C  CB  . TRP A 1 169 ? -39.859 -20.341 -14.371 0.41 52.64  ? 432  TRP A CB  1 
ATOM   1118 C  CG  . TRP A 1 169 ? -39.646 -21.798 -14.653 0.41 51.41  ? 432  TRP A CG  1 
ATOM   1119 C  CD1 . TRP A 1 169 ? -40.471 -22.829 -14.312 0.41 51.94  ? 432  TRP A CD1 1 
ATOM   1120 C  CD2 . TRP A 1 169 ? -38.510 -22.399 -15.304 0.41 51.39  ? 432  TRP A CD2 1 
ATOM   1121 N  NE1 . TRP A 1 169 ? -39.937 -24.024 -14.714 0.41 52.53  ? 432  TRP A NE1 1 
ATOM   1122 C  CE2 . TRP A 1 169 ? -38.734 -23.793 -15.325 0.41 50.18  ? 432  TRP A CE2 1 
ATOM   1123 C  CE3 . TRP A 1 169 ? -37.337 -21.900 -15.882 0.41 51.81  ? 432  TRP A CE3 1 
ATOM   1124 C  CZ2 . TRP A 1 169 ? -37.830 -24.686 -15.898 0.41 50.00  ? 432  TRP A CZ2 1 
ATOM   1125 C  CZ3 . TRP A 1 169 ? -36.441 -22.786 -16.442 0.41 50.99  ? 432  TRP A CZ3 1 
ATOM   1126 C  CH2 . TRP A 1 169 ? -36.688 -24.159 -16.453 0.41 49.65  ? 432  TRP A CH2 1 
ATOM   1127 N  N   . GLU A 1 170 ? -39.520 -17.698 -12.232 0.41 59.61  ? 433  GLU A N   1 
ATOM   1128 C  CA  . GLU A 1 170 ? -39.540 -16.242 -11.910 0.41 59.48  ? 433  GLU A CA  1 
ATOM   1129 C  C   . GLU A 1 170 ? -38.136 -15.834 -11.443 0.41 56.57  ? 433  GLU A C   1 
ATOM   1130 O  O   . GLU A 1 170 ? -37.649 -14.768 -11.876 0.41 57.99  ? 433  GLU A O   1 
ATOM   1131 C  CB  . GLU A 1 170 ? -40.610 -15.916 -10.858 0.41 61.73  ? 433  GLU A CB  1 
ATOM   1132 C  CG  . GLU A 1 170 ? -42.027 -16.294 -11.277 0.41 64.34  ? 433  GLU A CG  1 
ATOM   1133 C  CD  . GLU A 1 170 ? -43.057 -16.456 -10.162 0.41 65.75  ? 433  GLU A CD  1 
ATOM   1134 O  OE1 . GLU A 1 170 ? -42.919 -15.782 -9.117  0.41 65.74  ? 433  GLU A OE1 1 
ATOM   1135 O  OE2 . GLU A 1 170 ? -44.010 -17.253 -10.345 0.41 60.52  ? 433  GLU A OE2 1 
ATOM   1136 N  N   . LEU A 1 171 ? -37.502 -16.670 -10.615 0.41 58.13  ? 434  LEU A N   1 
ATOM   1137 C  CA  . LEU A 1 171 ? -36.097 -16.485 -10.148 0.41 60.35  ? 434  LEU A CA  1 
ATOM   1138 C  C   . LEU A 1 171 ? -35.168 -16.498 -11.369 0.41 59.35  ? 434  LEU A C   1 
ATOM   1139 O  O   . LEU A 1 171 ? -34.377 -15.538 -11.526 0.41 55.43  ? 434  LEU A O   1 
ATOM   1140 C  CB  . LEU A 1 171 ? -35.717 -17.595 -9.160  0.41 62.06  ? 434  LEU A CB  1 
ATOM   1141 C  CG  . LEU A 1 171 ? -36.710 -17.871 -8.031  0.41 64.63  ? 434  LEU A CG  1 
ATOM   1142 C  CD1 . LEU A 1 171 ? -36.176 -18.948 -7.097  0.41 66.57  ? 434  LEU A CD1 1 
ATOM   1143 C  CD2 . LEU A 1 171 ? -37.025 -16.601 -7.253  0.41 65.18  ? 434  LEU A CD2 1 
ATOM   1144 N  N   . VAL A 1 172 ? -35.292 -17.533 -12.210 0.41 57.37  ? 435  VAL A N   1 
ATOM   1145 C  CA  . VAL A 1 172 ? -34.554 -17.682 -13.502 0.41 55.79  ? 435  VAL A CA  1 
ATOM   1146 C  C   . VAL A 1 172 ? -34.711 -16.385 -14.303 0.41 53.10  ? 435  VAL A C   1 
ATOM   1147 O  O   . VAL A 1 172 ? -33.683 -15.752 -14.627 0.41 53.67  ? 435  VAL A O   1 
ATOM   1148 C  CB  . VAL A 1 172 ? -35.045 -18.903 -14.307 0.41 58.05  ? 435  VAL A CB  1 
ATOM   1149 C  CG1 . VAL A 1 172 ? -34.429 -18.943 -15.700 0.41 56.85  ? 435  VAL A CG1 1 
ATOM   1150 C  CG2 . VAL A 1 172 ? -34.795 -20.215 -13.572 0.41 55.76  ? 435  VAL A CG2 1 
ATOM   1151 N  N   . ASP A 1 173 ? -35.951 -15.975 -14.579 0.41 55.12  ? 436  ASP A N   1 
ATOM   1152 C  CA  . ASP A 1 173 ? -36.232 -14.768 -15.404 0.41 56.01  ? 436  ASP A CA  1 
ATOM   1153 C  C   . ASP A 1 173 ? -35.625 -13.528 -14.734 0.41 55.09  ? 436  ASP A C   1 
ATOM   1154 O  O   . ASP A 1 173 ? -35.166 -12.639 -15.481 0.41 56.84  ? 436  ASP A O   1 
ATOM   1155 C  CB  . ASP A 1 173 ? -37.724 -14.608 -15.721 0.41 59.51  ? 436  ASP A CB  1 
ATOM   1156 C  CG  . ASP A 1 173 ? -38.116 -15.198 -17.067 0.41 60.05  ? 436  ASP A CG  1 
ATOM   1157 O  OD1 . ASP A 1 173 ? -37.668 -14.656 -18.106 0.41 61.05  ? 436  ASP A OD1 1 
ATOM   1158 O  OD2 . ASP A 1 173 ? -38.848 -16.210 -17.071 0.41 64.69  ? 436  ASP A OD2 1 
ATOM   1159 N  N   . LYS A 1 174 ? -35.585 -13.455 -13.397 1.00 56.86  ? 437  LYS A N   1 
ATOM   1160 C  CA  . LYS A 1 174 ? -34.950 -12.279 -12.742 1.00 58.18  ? 437  LYS A CA  1 
ATOM   1161 C  C   . LYS A 1 174 ? -33.479 -12.250 -13.163 1.00 58.44  ? 437  LYS A C   1 
ATOM   1162 O  O   . LYS A 1 174 ? -33.023 -11.199 -13.680 1.00 62.70  ? 437  LYS A O   1 
ATOM   1163 C  CB  . LYS A 1 174 ? -35.125 -12.295 -11.220 1.00 64.84  ? 437  LYS A CB  1 
ATOM   1164 C  CG  . LYS A 1 174 ? -34.819 -10.963 -10.546 1.00 70.32  ? 437  LYS A CG  1 
ATOM   1165 C  CD  . LYS A 1 174 ? -34.789 -11.020 -9.015  1.00 70.35  ? 437  LYS A CD  1 
ATOM   1166 C  CE  . LYS A 1 174 ? -34.133 -9.791  -8.413  1.00 71.51  ? 437  LYS A CE  1 
ATOM   1167 N  NZ  . LYS A 1 174 ? -34.033 -9.896  -6.936  1.00 81.03  ? 437  LYS A NZ  1 
ATOM   1168 N  N   . GLU A 1 175 ? -32.779 -13.379 -13.022 1.00 61.63  ? 438  GLU A N   1 
ATOM   1169 C  CA  . GLU A 1 175 ? -31.333 -13.479 -13.371 1.00 58.23  ? 438  GLU A CA  1 
ATOM   1170 C  C   . GLU A 1 175 ? -31.152 -13.201 -14.859 1.00 51.90  ? 438  GLU A C   1 
ATOM   1171 O  O   . GLU A 1 175 ? -30.225 -12.434 -15.222 1.00 57.26  ? 438  GLU A O   1 
ATOM   1172 C  CB  . GLU A 1 175 ? -30.798 -14.878 -13.107 1.00 67.90  ? 438  GLU A CB  1 
ATOM   1173 C  CG  . GLU A 1 175 ? -29.978 -14.997 -11.853 1.00 75.91  ? 438  GLU A CG  1 
ATOM   1174 C  CD  . GLU A 1 175 ? -28.722 -14.157 -11.804 1.00 61.08  ? 438  GLU A CD  1 
ATOM   1175 O  OE1 . GLU A 1 175 ? -27.669 -14.650 -12.186 1.00 77.52  ? 438  GLU A OE1 1 
ATOM   1176 O  OE2 . GLU A 1 175 ? -28.796 -13.049 -11.323 1.00 68.34  ? 438  GLU A OE2 1 
ATOM   1177 N  N   . ARG A 1 176 ? -32.008 -13.832 -15.670 1.00 55.59  ? 439  ARG A N   1 
ATOM   1178 C  CA  . ARG A 1 176 ? -32.005 -13.706 -17.147 1.00 51.05  ? 439  ARG A CA  1 
ATOM   1179 C  C   . ARG A 1 176 ? -31.981 -12.234 -17.528 1.00 57.08  ? 439  ARG A C   1 
ATOM   1180 O  O   . ARG A 1 176 ? -31.059 -11.839 -18.287 1.00 57.71  ? 439  ARG A O   1 
ATOM   1181 C  CB  . ARG A 1 176 ? -33.220 -14.430 -17.708 1.00 54.65  ? 439  ARG A CB  1 
ATOM   1182 C  CG  . ARG A 1 176 ? -33.175 -14.604 -19.213 1.00 55.26  ? 439  ARG A CG  1 
ATOM   1183 C  CD  . ARG A 1 176 ? -33.980 -15.829 -19.599 1.00 50.27  ? 439  ARG A CD  1 
ATOM   1184 N  NE  . ARG A 1 176 ? -33.988 -15.803 -21.040 1.00 65.83  ? 439  ARG A NE  1 
ATOM   1185 C  CZ  . ARG A 1 176 ? -34.786 -16.495 -21.820 1.00 82.11  ? 439  ARG A CZ  1 
ATOM   1186 N  NH1 . ARG A 1 176 ? -35.652 -17.351 -21.290 1.00 96.06  ? 439  ARG A NH1 1 
ATOM   1187 N  NH2 . ARG A 1 176 ? -34.682 -16.341 -23.134 1.00 75.72  ? 439  ARG A NH2 1 
ATOM   1188 N  N   . ASN A 1 177 ? -32.914 -11.424 -16.986 1.00 60.62  ? 440  ASN A N   1 
ATOM   1189 C  CA  . ASN A 1 177 ? -32.997 -9.971  -17.307 1.00 56.05  ? 440  ASN A CA  1 
ATOM   1190 C  C   . ASN A 1 177 ? -31.751 -9.277  -16.766 1.00 53.10  ? 440  ASN A C   1 
ATOM   1191 O  O   . ASN A 1 177 ? -31.215 -8.405  -17.471 1.00 61.61  ? 440  ASN A O   1 
ATOM   1192 C  CB  . ASN A 1 177 ? -34.329 -9.345  -16.870 1.00 63.27  ? 440  ASN A CB  1 
ATOM   1193 C  CG  . ASN A 1 177 ? -35.432 -9.720  -17.841 1.00 65.50  ? 440  ASN A CG  1 
ATOM   1194 O  OD1 . ASN A 1 177 ? -35.546 -9.152  -18.933 1.00 78.03  ? 440  ASN A OD1 1 
ATOM   1195 N  ND2 . ASN A 1 177 ? -36.202 -10.734 -17.494 1.00 61.55  ? 440  ASN A ND2 1 
ATOM   1196 N  N   . LEU A 1 178 ? -31.232 -9.715  -15.621 1.00 57.50  ? 441  LEU A N   1 
ATOM   1197 C  CA  . LEU A 1 178 ? -29.915 -9.245  -15.113 1.00 61.10  ? 441  LEU A CA  1 
ATOM   1198 C  C   . LEU A 1 178 ? -28.806 -9.531  -16.140 1.00 57.33  ? 441  LEU A C   1 
ATOM   1199 O  O   . LEU A 1 178 ? -28.044 -8.585  -16.476 1.00 57.68  ? 441  LEU A O   1 
ATOM   1200 C  CB  . LEU A 1 178 ? -29.650 -9.889  -13.751 1.00 70.20  ? 441  LEU A CB  1 
ATOM   1201 C  CG  . LEU A 1 178 ? -30.399 -9.234  -12.585 1.00 76.57  ? 441  LEU A CG  1 
ATOM   1202 C  CD1 . LEU A 1 178 ? -30.177 -9.994  -11.275 1.00 77.81  ? 441  LEU A CD1 1 
ATOM   1203 C  CD2 . LEU A 1 178 ? -29.987 -7.770  -12.435 1.00 76.59  ? 441  LEU A CD2 1 
ATOM   1204 N  N   . HIS A 1 179 ? -28.746 -10.734 -16.708 1.00 55.26  ? 442  HIS A N   1 
ATOM   1205 C  CA  . HIS A 1 179 ? -27.755 -11.075 -17.778 1.00 56.44  ? 442  HIS A CA  1 
ATOM   1206 C  C   . HIS A 1 179 ? -27.941 -10.185 -19.026 1.00 55.80  ? 442  HIS A C   1 
ATOM   1207 O  O   . HIS A 1 179 ? -26.918 -9.733  -19.579 1.00 56.01  ? 442  HIS A O   1 
ATOM   1208 C  CB  . HIS A 1 179 ? -27.809 -12.582 -18.099 1.00 56.02  ? 442  HIS A CB  1 
ATOM   1209 C  CG  . HIS A 1 179 ? -27.241 -13.447 -17.016 1.00 53.83  ? 442  HIS A CG  1 
ATOM   1210 N  ND1 . HIS A 1 179 ? -27.170 -14.821 -17.127 1.00 46.62  ? 442  HIS A ND1 1 
ATOM   1211 C  CD2 . HIS A 1 179 ? -26.683 -13.120 -15.824 1.00 48.99  ? 442  HIS A CD2 1 
ATOM   1212 C  CE1 . HIS A 1 179 ? -26.644 -15.300 -16.012 1.00 52.57  ? 442  HIS A CE1 1 
ATOM   1213 N  NE2 . HIS A 1 179 ? -26.314 -14.264 -15.200 1.00 46.11  ? 442  HIS A NE2 1 
ATOM   1214 N  N   . LEU A 1 180 ? -29.183 -9.897  -19.462 1.00 71.82  ? 443  LEU A N   1 
ATOM   1215 C  CA  . LEU A 1 180 ? -29.449 -8.997  -20.637 1.00 66.46  ? 443  LEU A CA  1 
ATOM   1216 C  C   . LEU A 1 180 ? -28.971 -7.574  -20.314 1.00 60.04  ? 443  LEU A C   1 
ATOM   1217 O  O   . LEU A 1 180 ? -28.520 -6.893  -21.232 1.00 64.36  ? 443  LEU A O   1 
ATOM   1218 C  CB  . LEU A 1 180 ? -30.934 -9.030  -21.022 1.00 62.92  ? 443  LEU A CB  1 
ATOM   1219 C  CG  . LEU A 1 180 ? -31.462 -10.379 -21.523 1.00 62.43  ? 443  LEU A CG  1 
ATOM   1220 C  CD1 . LEU A 1 180 ? -32.976 -10.382 -21.619 1.00 65.86  ? 443  LEU A CD1 1 
ATOM   1221 C  CD2 . LEU A 1 180 ? -30.860 -10.765 -22.865 1.00 62.81  ? 443  LEU A CD2 1 
ATOM   1222 N  N   . GLU A 1 181 ? -28.981 -7.199  -19.032 1.00 69.63  ? 444  GLU A N   1 
ATOM   1223 C  CA  . GLU A 1 181 ? -28.442 -5.928  -18.461 1.00 79.28  ? 444  GLU A CA  1 
ATOM   1224 C  C   . GLU A 1 181 ? -26.907 -5.983  -18.340 1.00 75.12  ? 444  GLU A C   1 
ATOM   1225 O  O   . GLU A 1 181 ? -26.287 -4.935  -18.045 1.00 70.30  ? 444  GLU A O   1 
ATOM   1226 C  CB  . GLU A 1 181 ? -29.040 -5.736  -17.062 1.00 91.51  ? 444  GLU A CB  1 
ATOM   1227 C  CG  . GLU A 1 181 ? -29.801 -4.441  -16.821 1.00 95.29  ? 444  GLU A CG  1 
ATOM   1228 C  CD  . GLU A 1 181 ? -30.508 -4.460  -15.468 1.00 97.12  ? 444  GLU A CD  1 
ATOM   1229 O  OE1 . GLU A 1 181 ? -30.065 -3.709  -14.560 1.00 95.26  ? 444  GLU A OE1 1 
ATOM   1230 O  OE2 . GLU A 1 181 ? -31.477 -5.271  -15.300 1.00 81.64  ? 444  GLU A OE2 1 
ATOM   1231 N  N   . GLY A 1 182 ? -26.306 -7.170  -18.499 1.00 73.23  ? 445  GLY A N   1 
ATOM   1232 C  CA  . GLY A 1 182 ? -24.847 -7.377  -18.393 1.00 61.15  ? 445  GLY A CA  1 
ATOM   1233 C  C   . GLY A 1 182 ? -24.383 -7.554  -16.952 1.00 55.25  ? 445  GLY A C   1 
ATOM   1234 O  O   . GLY A 1 182 ? -23.203 -7.299  -16.684 1.00 63.72  ? 445  GLY A O   1 
ATOM   1235 N  N   . LYS A 1 183 ? -25.266 -7.991  -16.060 1.00 48.14  ? 446  LYS A N   1 
ATOM   1236 C  CA  . LYS A 1 183 ? -25.005 -8.118  -14.604 1.00 54.02  ? 446  LYS A CA  1 
ATOM   1237 C  C   . LYS A 1 183 ? -25.405 -9.512  -14.118 1.00 47.57  ? 446  LYS A C   1 
ATOM   1238 O  O   . LYS A 1 183 ? -26.206 -10.183 -14.793 1.00 47.50  ? 446  LYS A O   1 
ATOM   1239 C  CB  . LYS A 1 183 ? -25.836 -7.112  -13.792 1.00 68.72  ? 446  LYS A CB  1 
ATOM   1240 C  CG  . LYS A 1 183 ? -25.548 -5.649  -14.091 1.00 73.64  ? 446  LYS A CG  1 
ATOM   1241 C  CD  . LYS A 1 183 ? -26.622 -4.708  -13.592 1.00 81.17  ? 446  LYS A CD  1 
ATOM   1242 C  CE  . LYS A 1 183 ? -26.744 -3.486  -14.480 1.00 90.56  ? 446  LYS A CE  1 
ATOM   1243 N  NZ  . LYS A 1 183 ? -27.077 -2.271  -13.699 1.00 97.63  ? 446  LYS A NZ  1 
ATOM   1244 N  N   . CYS A 1 184 ? -24.943 -9.901  -12.933 1.00 51.32  ? 447  CYS A N   1 
ATOM   1245 C  CA  . CYS A 1 184 ? -25.177 -11.258 -12.376 1.00 52.18  ? 447  CYS A CA  1 
ATOM   1246 C  C   . CYS A 1 184 ? -25.389 -11.178 -10.862 1.00 53.96  ? 447  CYS A C   1 
ATOM   1247 O  O   . CYS A 1 184 ? -24.696 -10.363 -10.235 1.00 60.08  ? 447  CYS A O   1 
ATOM   1248 C  CB  . CYS A 1 184 ? -23.962 -12.133 -12.714 1.00 59.18  ? 447  CYS A CB  1 
ATOM   1249 S  SG  . CYS A 1 184 ? -24.198 -13.873 -12.284 1.00 52.00  ? 447  CYS A SG  1 
ATOM   1250 N  N   . GLU A 1 185 ? -26.220 -12.058 -10.290 1.00 56.54  ? 448  GLU A N   1 
ATOM   1251 C  CA  . GLU A 1 185 ? -26.533 -12.010 -8.836  1.00 61.56  ? 448  GLU A CA  1 
ATOM   1252 C  C   . GLU A 1 185 ? -26.467 -13.355 -8.101  1.00 63.25  ? 448  GLU A C   1 
ATOM   1253 O  O   . GLU A 1 185 ? -26.128 -13.358 -6.881  1.00 63.88  ? 448  GLU A O   1 
ATOM   1254 C  CB  . GLU A 1 185 ? -27.934 -11.422 -8.620  1.00 75.10  ? 448  GLU A CB  1 
ATOM   1255 C  CG  . GLU A 1 185 ? -28.204 -10.955 -7.194  1.00 78.58  ? 448  GLU A CG  1 
ATOM   1256 C  CD  . GLU A 1 185 ? -29.640 -10.547 -6.892  1.00 84.47  ? 448  GLU A CD  1 
ATOM   1257 O  OE1 . GLU A 1 185 ? -29.856 -9.330  -6.703  1.00 83.24  ? 448  GLU A OE1 1 
ATOM   1258 O  OE2 . GLU A 1 185 ? -30.539 -11.445 -6.833  1.00 79.38  ? 448  GLU A OE2 1 
ATOM   1259 N  N   . THR A 1 186 ? -26.801 -14.461 -8.775  0.41 63.35  ? 449  THR A N   1 
ATOM   1260 C  CA  . THR A 1 186 ? -27.021 -15.780 -8.125  0.41 64.69  ? 449  THR A CA  1 
ATOM   1261 C  C   . THR A 1 186 ? -26.243 -16.909 -8.816  0.41 63.04  ? 449  THR A C   1 
ATOM   1262 O  O   . THR A 1 186 ? -26.456 -18.065 -8.411  0.41 66.21  ? 449  THR A O   1 
ATOM   1263 C  CB  . THR A 1 186 ? -28.520 -16.102 -8.080  0.41 68.81  ? 449  THR A CB  1 
ATOM   1264 O  OG1 . THR A 1 186 ? -28.982 -16.247 -9.423  0.41 69.67  ? 449  THR A OG1 1 
ATOM   1265 C  CG2 . THR A 1 186 ? -29.325 -15.034 -7.373  0.41 70.72  ? 449  THR A CG2 1 
ATOM   1266 N  N   . CYS A 1 187 ? -25.368 -16.615 -9.785  0.41 59.96  ? 450  CYS A N   1 
ATOM   1267 C  CA  . CYS A 1 187 ? -24.532 -17.635 -10.482 0.41 59.10  ? 450  CYS A CA  1 
ATOM   1268 C  C   . CYS A 1 187 ? -23.154 -17.730 -9.803  0.41 58.93  ? 450  CYS A C   1 
ATOM   1269 O  O   . CYS A 1 187 ? -22.183 -17.113 -10.297 0.41 55.89  ? 450  CYS A O   1 
ATOM   1270 C  CB  . CYS A 1 187 ? -24.443 -17.339 -11.975 0.41 58.16  ? 450  CYS A CB  1 
ATOM   1271 S  SG  . CYS A 1 187 ? -26.061 -17.380 -12.798 0.41 55.40  ? 450  CYS A SG  1 
ATOM   1272 N  N   . VAL A 1 188 ? -23.091 -18.498 -8.709  0.41 61.55  ? 451  VAL A N   1 
ATOM   1273 C  CA  . VAL A 1 188 ? -21.877 -18.756 -7.876  0.41 65.25  ? 451  VAL A CA  1 
ATOM   1274 C  C   . VAL A 1 188 ? -21.649 -20.272 -7.805  0.41 66.11  ? 451  VAL A C   1 
ATOM   1275 O  O   . VAL A 1 188 ? -22.622 -21.007 -7.550  0.41 62.10  ? 451  VAL A O   1 
ATOM   1276 C  CB  . VAL A 1 188 ? -22.035 -18.149 -6.468  0.41 66.01  ? 451  VAL A CB  1 
ATOM   1277 C  CG1 . VAL A 1 188 ? -20.881 -18.519 -5.545  0.41 65.77  ? 451  VAL A CG1 1 
ATOM   1278 C  CG2 . VAL A 1 188 ? -22.209 -16.639 -6.523  0.41 67.42  ? 451  VAL A CG2 1 
ATOM   1279 N  N   . TYR A 1 189 ? -20.403 -20.713 -7.989  0.41 72.01  ? 452  TYR A N   1 
ATOM   1280 C  CA  . TYR A 1 189 ? -20.004 -22.147 -8.006  0.41 76.70  ? 452  TYR A CA  1 
ATOM   1281 C  C   . TYR A 1 189 ? -19.790 -22.648 -6.573  0.41 79.45  ? 452  TYR A C   1 
ATOM   1282 O  O   . TYR A 1 189 ? -19.485 -21.827 -5.690  0.41 80.74  ? 452  TYR A O   1 
ATOM   1283 C  CB  . TYR A 1 189 ? -18.760 -22.345 -8.874  0.41 75.25  ? 452  TYR A CB  1 
ATOM   1284 C  CG  . TYR A 1 189 ? -19.024 -22.190 -10.349 0.41 75.42  ? 452  TYR A CG  1 
ATOM   1285 C  CD1 . TYR A 1 189 ? -19.692 -23.175 -11.060 0.41 76.69  ? 452  TYR A CD1 1 
ATOM   1286 C  CD2 . TYR A 1 189 ? -18.636 -21.048 -11.030 0.41 77.13  ? 452  TYR A CD2 1 
ATOM   1287 C  CE1 . TYR A 1 189 ? -19.953 -23.038 -12.413 0.41 77.90  ? 452  TYR A CE1 1 
ATOM   1288 C  CE2 . TYR A 1 189 ? -18.886 -20.895 -12.385 0.41 79.12  ? 452  TYR A CE2 1 
ATOM   1289 C  CZ  . TYR A 1 189 ? -19.548 -21.894 -13.079 0.41 79.74  ? 452  TYR A CZ  1 
ATOM   1290 O  OH  . TYR A 1 189 ? -19.807 -21.758 -14.413 0.41 82.93  ? 452  TYR A OH  1 
ATOM   1291 N  N   . ASN A 1 190 ? -19.962 -23.959 -6.366  0.41 86.07  ? 453  ASN A N   1 
ATOM   1292 C  CA  . ASN A 1 190 ? -19.899 -24.640 -5.044  0.41 88.98  ? 453  ASN A CA  1 
ATOM   1293 C  C   . ASN A 1 190 ? -18.935 -25.830 -5.123  0.41 91.38  ? 453  ASN A C   1 
ATOM   1294 O  O   . ASN A 1 190 ? -19.411 -26.960 -5.343  0.41 90.38  ? 453  ASN A O   1 
ATOM   1295 C  CB  . ASN A 1 190 ? -21.285 -25.101 -4.584  0.41 90.31  ? 453  ASN A CB  1 
ATOM   1296 C  CG  . ASN A 1 190 ? -22.300 -23.978 -4.523  0.41 93.13  ? 453  ASN A CG  1 
ATOM   1297 O  OD1 . ASN A 1 190 ? -22.393 -23.164 -5.440  0.41 97.86  ? 453  ASN A OD1 1 
ATOM   1298 N  ND2 . ASN A 1 190 ? -23.085 -23.940 -3.458  0.41 96.69  ? 453  ASN A ND2 1 
ATOM   1299 N  N   . MET A 1 191 ? -17.633 -25.579 -4.945  0.41 99.60  ? 454  MET A N   1 
ATOM   1300 C  CA  . MET A 1 191 ? -16.555 -26.607 -4.987  0.41 106.35 ? 454  MET A CA  1 
ATOM   1301 C  C   . MET A 1 191 ? -16.740 -27.577 -3.813  0.41 109.83 ? 454  MET A C   1 
ATOM   1302 O  O   . MET A 1 191 ? -16.949 -27.092 -2.684  0.41 112.85 ? 454  MET A O   1 
ATOM   1303 C  CB  . MET A 1 191 ? -15.174 -25.951 -4.892  0.41 110.02 ? 454  MET A CB  1 
ATOM   1304 C  CG  . MET A 1 191 ? -14.015 -26.926 -5.022  0.41 115.69 ? 454  MET A CG  1 
ATOM   1305 S  SD  . MET A 1 191 ? -12.429 -26.187 -4.548  0.41 122.40 ? 454  MET A SD  1 
ATOM   1306 C  CE  . MET A 1 191 ? -12.224 -24.974 -5.852  0.41 122.57 ? 454  MET A CE  1 
ATOM   1307 N  N   . MET A 1 192 ? -16.662 -28.888 -4.077  0.41 112.79 ? 455  MET A N   1 
ATOM   1308 C  CA  . MET A 1 192 ? -16.815 -29.972 -3.065  0.41 111.52 ? 455  MET A CA  1 
ATOM   1309 C  C   . MET A 1 192 ? -15.872 -31.137 -3.402  0.41 108.64 ? 455  MET A C   1 
ATOM   1310 O  O   . MET A 1 192 ? -16.266 -31.982 -4.232  0.41 107.55 ? 455  MET A O   1 
ATOM   1311 C  CB  . MET A 1 192 ? -18.264 -30.470 -3.011  0.41 111.61 ? 455  MET A CB  1 
ATOM   1312 C  CG  . MET A 1 192 ? -19.198 -29.528 -2.269  0.41 111.54 ? 455  MET A CG  1 
ATOM   1313 S  SD  . MET A 1 192 ? -20.945 -29.980 -2.422  0.41 112.72 ? 455  MET A SD  1 
ATOM   1314 C  CE  . MET A 1 192 ? -20.951 -31.594 -1.641  0.41 111.04 ? 455  MET A CE  1 
ATOM   1315 N  N   . ALA A 1 210 ? -12.070 -31.251 -9.737  0.41 105.56 ? 473  ALA A N   1 
ATOM   1316 C  CA  . ALA A 1 210 ? -13.014 -30.772 -8.698  0.41 103.74 ? 473  ALA A CA  1 
ATOM   1317 C  C   . ALA A 1 210 ? -14.327 -30.334 -9.358  0.41 102.26 ? 473  ALA A C   1 
ATOM   1318 O  O   . ALA A 1 210 ? -14.293 -29.364 -10.146 0.41 107.38 ? 473  ALA A O   1 
ATOM   1319 C  CB  . ALA A 1 210 ? -12.383 -29.643 -7.918  0.41 103.86 ? 473  ALA A CB  1 
ATOM   1320 N  N   . ILE A 1 211 ? -15.434 -31.018 -9.044  0.41 97.18  ? 474  ILE A N   1 
ATOM   1321 C  CA  . ILE A 1 211 ? -16.790 -30.724 -9.603  0.41 89.70  ? 474  ILE A CA  1 
ATOM   1322 C  C   . ILE A 1 211 ? -17.334 -29.484 -8.884  0.41 82.84  ? 474  ILE A C   1 
ATOM   1323 O  O   . ILE A 1 211 ? -17.497 -29.538 -7.646  0.41 83.30  ? 474  ILE A O   1 
ATOM   1324 C  CB  . ILE A 1 211 ? -17.747 -31.932 -9.485  0.41 90.12  ? 474  ILE A CB  1 
ATOM   1325 C  CG1 . ILE A 1 211 ? -17.142 -33.211 -10.074 0.41 93.47  ? 474  ILE A CG1 1 
ATOM   1326 C  CG2 . ILE A 1 211 ? -19.098 -31.616 -10.117 0.41 87.70  ? 474  ILE A CG2 1 
ATOM   1327 C  CD1 . ILE A 1 211 ? -16.601 -34.182 -9.044  0.41 93.26  ? 474  ILE A CD1 1 
ATOM   1328 N  N   . TRP A 1 212 ? -17.571 -28.407 -9.638  0.41 73.52  ? 475  TRP A N   1 
ATOM   1329 C  CA  . TRP A 1 212 ? -18.160 -27.131 -9.153  0.41 71.29  ? 475  TRP A CA  1 
ATOM   1330 C  C   . TRP A 1 212 ? -19.657 -27.130 -9.477  0.41 69.45  ? 475  TRP A C   1 
ATOM   1331 O  O   . TRP A 1 212 ? -19.998 -26.929 -10.656 0.41 73.52  ? 475  TRP A O   1 
ATOM   1332 C  CB  . TRP A 1 212 ? -17.447 -25.930 -9.790  0.41 69.66  ? 475  TRP A CB  1 
ATOM   1333 C  CG  . TRP A 1 212 ? -15.979 -25.828 -9.502  0.41 68.23  ? 475  TRP A CG  1 
ATOM   1334 C  CD1 . TRP A 1 212 ? -15.206 -26.689 -8.776  0.41 67.82  ? 475  TRP A CD1 1 
ATOM   1335 C  CD2 . TRP A 1 212 ? -15.089 -24.810 -9.990  0.41 66.11  ? 475  TRP A CD2 1 
ATOM   1336 N  NE1 . TRP A 1 212 ? -13.905 -26.267 -8.763  0.41 66.46  ? 475  TRP A NE1 1 
ATOM   1337 C  CE2 . TRP A 1 212 ? -13.801 -25.118 -9.501  0.41 65.06  ? 475  TRP A CE2 1 
ATOM   1338 C  CE3 . TRP A 1 212 ? -15.255 -23.665 -10.781 0.41 65.11  ? 475  TRP A CE3 1 
ATOM   1339 C  CZ2 . TRP A 1 212 ? -12.690 -24.323 -9.781  0.41 64.13  ? 475  TRP A CZ2 1 
ATOM   1340 C  CZ3 . TRP A 1 212 ? -14.157 -22.881 -11.059 0.41 64.72  ? 475  TRP A CZ3 1 
ATOM   1341 C  CH2 . TRP A 1 212 ? -12.892 -23.211 -10.569 0.41 66.37  ? 475  TRP A CH2 1 
ATOM   1342 N  N   . TYR A 1 213 ? -20.508 -27.357 -8.472  0.41 67.89  ? 476  TYR A N   1 
ATOM   1343 C  CA  . TYR A 1 213 ? -21.989 -27.407 -8.599  0.41 64.15  ? 476  TYR A CA  1 
ATOM   1344 C  C   . TYR A 1 213 ? -22.547 -25.975 -8.570  0.41 60.87  ? 476  TYR A C   1 
ATOM   1345 O  O   . TYR A 1 213 ? -21.810 -25.046 -8.186  0.41 56.79  ? 476  TYR A O   1 
ATOM   1346 C  CB  . TYR A 1 213 ? -22.586 -28.296 -7.502  0.41 66.84  ? 476  TYR A CB  1 
ATOM   1347 C  CG  . TYR A 1 213 ? -22.018 -29.694 -7.448  0.41 70.05  ? 476  TYR A CG  1 
ATOM   1348 C  CD1 . TYR A 1 213 ? -22.567 -30.720 -8.203  0.41 72.11  ? 476  TYR A CD1 1 
ATOM   1349 C  CD2 . TYR A 1 213 ? -20.923 -29.996 -6.653  0.41 74.30  ? 476  TYR A CD2 1 
ATOM   1350 C  CE1 . TYR A 1 213 ? -22.050 -32.006 -8.166  0.41 73.64  ? 476  TYR A CE1 1 
ATOM   1351 C  CE2 . TYR A 1 213 ? -20.394 -31.278 -6.603  0.41 76.07  ? 476  TYR A CE2 1 
ATOM   1352 C  CZ  . TYR A 1 213 ? -20.959 -32.289 -7.362  0.41 73.60  ? 476  TYR A CZ  1 
ATOM   1353 O  OH  . TYR A 1 213 ? -20.445 -33.555 -7.321  0.41 70.07  ? 476  TYR A OH  1 
ATOM   1354 N  N   . MET A 1 214 ? -23.808 -25.804 -8.980  0.41 58.83  ? 477  MET A N   1 
ATOM   1355 C  CA  . MET A 1 214 ? -24.511 -24.491 -9.047  0.41 58.00  ? 477  MET A CA  1 
ATOM   1356 C  C   . MET A 1 214 ? -25.998 -24.698 -8.751  0.41 56.89  ? 477  MET A C   1 
ATOM   1357 O  O   . MET A 1 214 ? -26.439 -25.853 -8.787  0.41 57.79  ? 477  MET A O   1 
ATOM   1358 C  CB  . MET A 1 214 ? -24.369 -23.859 -10.435 0.41 57.19  ? 477  MET A CB  1 
ATOM   1359 C  CG  . MET A 1 214 ? -23.383 -22.710 -10.501 0.41 57.14  ? 477  MET A CG  1 
ATOM   1360 S  SD  . MET A 1 214 ? -23.330 -21.991 -12.164 0.41 59.26  ? 477  MET A SD  1 
ATOM   1361 C  CE  . MET A 1 214 ? -22.473 -20.452 -11.835 0.41 53.27  ? 477  MET A CE  1 
ATOM   1362 N  N   . TRP A 1 215 ? -26.741 -23.616 -8.490  0.41 58.41  ? 478  TRP A N   1 
ATOM   1363 C  CA  . TRP A 1 215 ? -28.223 -23.655 -8.353  0.41 61.32  ? 478  TRP A CA  1 
ATOM   1364 C  C   . TRP A 1 215 ? -28.848 -23.878 -9.738  0.41 60.48  ? 478  TRP A C   1 
ATOM   1365 O  O   . TRP A 1 215 ? -28.391 -23.239 -10.706 0.41 58.65  ? 478  TRP A O   1 
ATOM   1366 C  CB  . TRP A 1 215 ? -28.762 -22.405 -7.641  0.41 60.00  ? 478  TRP A CB  1 
ATOM   1367 C  CG  . TRP A 1 215 ? -29.071 -21.218 -8.504  0.41 63.13  ? 478  TRP A CG  1 
ATOM   1368 C  CD1 . TRP A 1 215 ? -28.180 -20.377 -9.105  0.41 64.45  ? 478  TRP A CD1 1 
ATOM   1369 C  CD2 . TRP A 1 215 ? -30.378 -20.696 -8.812  0.41 62.55  ? 478  TRP A CD2 1 
ATOM   1370 N  NE1 . TRP A 1 215 ? -28.837 -19.383 -9.783  0.41 64.10  ? 478  TRP A NE1 1 
ATOM   1371 C  CE2 . TRP A 1 215 ? -30.187 -19.553 -9.621  0.41 63.85  ? 478  TRP A CE2 1 
ATOM   1372 C  CE3 . TRP A 1 215 ? -31.684 -21.089 -8.496  0.41 60.78  ? 478  TRP A CE3 1 
ATOM   1373 C  CZ2 . TRP A 1 215 ? -31.255 -18.802 -10.112 0.41 62.44  ? 478  TRP A CZ2 1 
ATOM   1374 C  CZ3 . TRP A 1 215 ? -32.738 -20.348 -8.985  0.41 62.74  ? 478  TRP A CZ3 1 
ATOM   1375 C  CH2 . TRP A 1 215 ? -32.524 -19.221 -9.781  0.41 62.85  ? 478  TRP A CH2 1 
ATOM   1376 N  N   . LEU A 1 216 ? -29.836 -24.774 -9.819  0.41 60.69  ? 479  LEU A N   1 
ATOM   1377 C  CA  . LEU A 1 216 ? -30.428 -25.292 -11.082 0.41 61.86  ? 479  LEU A CA  1 
ATOM   1378 C  C   . LEU A 1 216 ? -30.672 -24.143 -12.070 0.41 62.39  ? 479  LEU A C   1 
ATOM   1379 O  O   . LEU A 1 216 ? -30.438 -24.351 -13.276 0.41 63.72  ? 479  LEU A O   1 
ATOM   1380 C  CB  . LEU A 1 216 ? -31.730 -26.030 -10.759 0.41 63.80  ? 479  LEU A CB  1 
ATOM   1381 C  CG  . LEU A 1 216 ? -32.258 -26.937 -11.868 0.41 65.84  ? 479  LEU A CG  1 
ATOM   1382 C  CD1 . LEU A 1 216 ? -31.294 -28.084 -12.140 0.41 64.72  ? 479  LEU A CD1 1 
ATOM   1383 C  CD2 . LEU A 1 216 ? -33.639 -27.472 -11.519 0.41 66.23  ? 479  LEU A CD2 1 
ATOM   1384 N  N   . GLY A 1 217 ? -31.108 -22.981 -11.573 0.41 61.48  ? 480  GLY A N   1 
ATOM   1385 C  CA  . GLY A 1 217 ? -31.352 -21.765 -12.374 0.41 61.21  ? 480  GLY A CA  1 
ATOM   1386 C  C   . GLY A 1 217 ? -30.169 -21.425 -13.264 0.41 60.55  ? 480  GLY A C   1 
ATOM   1387 O  O   . GLY A 1 217 ? -30.335 -21.459 -14.503 0.41 56.31  ? 480  GLY A O   1 
ATOM   1388 N  N   . ALA A 1 218 ? -29.014 -21.131 -12.651 0.41 58.87  ? 481  ALA A N   1 
ATOM   1389 C  CA  . ALA A 1 218 ? -27.736 -20.787 -13.326 0.41 53.71  ? 481  ALA A CA  1 
ATOM   1390 C  C   . ALA A 1 218 ? -27.373 -21.871 -14.349 0.41 51.33  ? 481  ALA A C   1 
ATOM   1391 O  O   . ALA A 1 218 ? -26.855 -21.513 -15.424 0.41 48.56  ? 481  ALA A O   1 
ATOM   1392 C  CB  . ALA A 1 218 ? -26.641 -20.617 -12.304 0.41 52.58  ? 481  ALA A CB  1 
ATOM   1393 N  N   . ARG A 1 219 ? -27.632 -23.141 -14.017 0.41 48.57  ? 482  ARG A N   1 
ATOM   1394 C  CA  . ARG A 1 219 ? -27.368 -24.313 -14.897 0.41 49.45  ? 482  ARG A CA  1 
ATOM   1395 C  C   . ARG A 1 219 ? -28.227 -24.181 -16.158 0.41 47.34  ? 482  ARG A C   1 
ATOM   1396 O  O   . ARG A 1 219 ? -27.709 -24.464 -17.263 0.41 41.34  ? 482  ARG A O   1 
ATOM   1397 C  CB  . ARG A 1 219 ? -27.681 -25.633 -14.187 0.41 50.15  ? 482  ARG A CB  1 
ATOM   1398 C  CG  . ARG A 1 219 ? -26.518 -26.612 -14.152 0.41 54.51  ? 482  ARG A CG  1 
ATOM   1399 C  CD  . ARG A 1 219 ? -25.411 -26.164 -13.211 0.41 57.03  ? 482  ARG A CD  1 
ATOM   1400 N  NE  . ARG A 1 219 ? -24.224 -25.673 -13.905 0.41 56.58  ? 482  ARG A NE  1 
ATOM   1401 C  CZ  . ARG A 1 219 ? -22.964 -25.942 -13.563 0.41 58.62  ? 482  ARG A CZ  1 
ATOM   1402 N  NH1 . ARG A 1 219 ? -21.971 -25.419 -14.263 0.41 58.98  ? 482  ARG A NH1 1 
ATOM   1403 N  NH2 . ARG A 1 219 ? -22.690 -26.730 -12.535 0.41 55.68  ? 482  ARG A NH2 1 
ATOM   1404 N  N   . PHE A 1 220 ? -29.485 -23.754 -16.000 0.41 44.95  ? 483  PHE A N   1 
ATOM   1405 C  CA  . PHE A 1 220 ? -30.427 -23.570 -17.132 0.41 44.32  ? 483  PHE A CA  1 
ATOM   1406 C  C   . PHE A 1 220 ? -29.899 -22.470 -18.055 0.41 42.65  ? 483  PHE A C   1 
ATOM   1407 O  O   . PHE A 1 220 ? -29.896 -22.664 -19.285 0.41 45.12  ? 483  PHE A O   1 
ATOM   1408 C  CB  . PHE A 1 220 ? -31.842 -23.214 -16.673 0.41 45.03  ? 483  PHE A CB  1 
ATOM   1409 C  CG  . PHE A 1 220 ? -32.722 -22.838 -17.835 0.41 43.15  ? 483  PHE A CG  1 
ATOM   1410 C  CD1 . PHE A 1 220 ? -33.096 -23.793 -18.768 0.41 44.59  ? 483  PHE A CD1 1 
ATOM   1411 C  CD2 . PHE A 1 220 ? -33.097 -21.523 -18.048 0.41 43.15  ? 483  PHE A CD2 1 
ATOM   1412 C  CE1 . PHE A 1 220 ? -33.864 -23.449 -19.870 0.41 45.88  ? 483  PHE A CE1 1 
ATOM   1413 C  CE2 . PHE A 1 220 ? -33.867 -21.179 -19.150 0.41 45.40  ? 483  PHE A CE2 1 
ATOM   1414 C  CZ  . PHE A 1 220 ? -34.251 -22.143 -20.057 0.41 45.55  ? 483  PHE A CZ  1 
ATOM   1415 N  N   . LEU A 1 221 ? -29.480 -21.347 -17.471 0.41 42.01  ? 484  LEU A N   1 
ATOM   1416 C  CA  . LEU A 1 221 ? -28.988 -20.158 -18.215 0.41 42.15  ? 484  LEU A CA  1 
ATOM   1417 C  C   . LEU A 1 221 ? -27.752 -20.541 -19.042 0.41 40.49  ? 484  LEU A C   1 
ATOM   1418 O  O   . LEU A 1 221 ? -27.639 -20.063 -20.202 0.41 38.67  ? 484  LEU A O   1 
ATOM   1419 C  CB  . LEU A 1 221 ? -28.690 -19.032 -17.221 0.41 43.82  ? 484  LEU A CB  1 
ATOM   1420 C  CG  . LEU A 1 221 ? -29.907 -18.444 -16.503 0.41 46.50  ? 484  LEU A CG  1 
ATOM   1421 C  CD1 . LEU A 1 221 ? -29.500 -17.247 -15.656 0.41 48.68  ? 484  LEU A CD1 1 
ATOM   1422 C  CD2 . LEU A 1 221 ? -30.994 -18.039 -17.487 0.41 47.49  ? 484  LEU A CD2 1 
ATOM   1423 N  N   . GLU A 1 222 ? -26.876 -21.394 -18.497 0.41 36.86  ? 485  GLU A N   1 
ATOM   1424 C  CA  . GLU A 1 222 ? -25.718 -21.947 -19.256 0.41 35.44  ? 485  GLU A CA  1 
ATOM   1425 C  C   . GLU A 1 222 ? -26.250 -22.851 -20.385 0.41 33.86  ? 485  GLU A C   1 
ATOM   1426 O  O   . GLU A 1 222 ? -25.775 -22.709 -21.535 0.41 30.35  ? 485  GLU A O   1 
ATOM   1427 C  CB  . GLU A 1 222 ? -24.747 -22.686 -18.326 0.41 35.45  ? 485  GLU A CB  1 
ATOM   1428 C  CG  . GLU A 1 222 ? -23.617 -23.375 -19.078 0.41 35.00  ? 485  GLU A CG  1 
ATOM   1429 C  CD  . GLU A 1 222 ? -22.686 -24.235 -18.242 0.41 34.63  ? 485  GLU A CD  1 
ATOM   1430 O  OE1 . GLU A 1 222 ? -21.491 -23.883 -18.153 0.41 33.63  ? 485  GLU A OE1 1 
ATOM   1431 O  OE2 . GLU A 1 222 ? -23.144 -25.263 -17.706 0.41 34.25  ? 485  GLU A OE2 1 
ATOM   1432 N  N   . PHE A 1 223 ? -27.196 -23.746 -20.080 0.41 33.79  ? 486  PHE A N   1 
ATOM   1433 C  CA  . PHE A 1 223 ? -27.749 -24.746 -21.038 0.41 35.25  ? 486  PHE A CA  1 
ATOM   1434 C  C   . PHE A 1 223 ? -28.483 -24.014 -22.165 0.41 37.27  ? 486  PHE A C   1 
ATOM   1435 O  O   . PHE A 1 223 ? -28.345 -24.404 -23.343 0.41 35.56  ? 486  PHE A O   1 
ATOM   1436 C  CB  . PHE A 1 223 ? -28.651 -25.751 -20.318 0.41 34.92  ? 486  PHE A CB  1 
ATOM   1437 C  CG  . PHE A 1 223 ? -29.397 -26.704 -21.219 0.41 35.28  ? 486  PHE A CG  1 
ATOM   1438 C  CD1 . PHE A 1 223 ? -28.734 -27.726 -21.880 0.41 33.79  ? 486  PHE A CD1 1 
ATOM   1439 C  CD2 . PHE A 1 223 ? -30.768 -26.580 -21.404 0.41 35.85  ? 486  PHE A CD2 1 
ATOM   1440 C  CE1 . PHE A 1 223 ? -29.422 -28.601 -22.708 0.41 35.53  ? 486  PHE A CE1 1 
ATOM   1441 C  CE2 . PHE A 1 223 ? -31.457 -27.457 -22.228 0.41 35.53  ? 486  PHE A CE2 1 
ATOM   1442 C  CZ  . PHE A 1 223 ? -30.784 -28.468 -22.878 0.41 36.82  ? 486  PHE A CZ  1 
ATOM   1443 N  N   . GLU A 1 224 ? -29.214 -22.959 -21.807 0.41 38.53  ? 487  GLU A N   1 
ATOM   1444 C  CA  . GLU A 1 224 ? -29.997 -22.126 -22.752 0.41 40.02  ? 487  GLU A CA  1 
ATOM   1445 C  C   . GLU A 1 224 ? -29.043 -21.438 -23.740 0.41 40.77  ? 487  GLU A C   1 
ATOM   1446 O  O   . GLU A 1 224 ? -29.366 -21.390 -24.948 0.41 42.07  ? 487  GLU A O   1 
ATOM   1447 C  CB  . GLU A 1 224 ? -30.836 -21.126 -21.955 0.41 41.20  ? 487  GLU A CB  1 
ATOM   1448 C  CG  . GLU A 1 224 ? -31.761 -20.280 -22.806 0.41 40.27  ? 487  GLU A CG  1 
ATOM   1449 C  CD  . GLU A 1 224 ? -32.816 -19.544 -22.001 0.41 40.30  ? 487  GLU A CD  1 
ATOM   1450 O  OE1 . GLU A 1 224 ? -34.005 -19.909 -22.138 0.41 36.00  ? 487  GLU A OE1 1 
ATOM   1451 O  OE2 . GLU A 1 224 ? -32.444 -18.607 -21.252 0.41 38.52  ? 487  GLU A OE2 1 
ATOM   1452 N  N   . ALA A 1 225 ? -27.898 -20.951 -23.260 1.00 38.43  ? 488  ALA A N   1 
ATOM   1453 C  CA  . ALA A 1 225 ? -26.955 -20.187 -24.085 1.00 37.71  ? 488  ALA A CA  1 
ATOM   1454 C  C   . ALA A 1 225 ? -26.017 -21.101 -24.847 1.00 36.48  ? 488  ALA A C   1 
ATOM   1455 O  O   . ALA A 1 225 ? -25.679 -20.689 -25.981 1.00 36.04  ? 488  ALA A O   1 
ATOM   1456 C  CB  . ALA A 1 225 ? -26.200 -19.230 -23.209 1.00 41.55  ? 488  ALA A CB  1 
ATOM   1457 N  N   . LEU A 1 226 ? -25.600 -22.234 -24.266 1.00 35.46  ? 489  LEU A N   1 
ATOM   1458 C  CA  . LEU A 1 226 ? -24.404 -22.997 -24.755 1.00 33.46  ? 489  LEU A CA  1 
ATOM   1459 C  C   . LEU A 1 226 ? -24.703 -24.481 -24.937 1.00 33.88  ? 489  LEU A C   1 
ATOM   1460 O  O   . LEU A 1 226 ? -23.815 -25.209 -25.500 1.00 33.95  ? 489  LEU A O   1 
ATOM   1461 C  CB  . LEU A 1 226 ? -23.231 -22.780 -23.800 1.00 32.86  ? 489  LEU A CB  1 
ATOM   1462 C  CG  . LEU A 1 226 ? -22.660 -21.364 -23.746 1.00 37.32  ? 489  LEU A CG  1 
ATOM   1463 C  CD1 . LEU A 1 226 ? -21.415 -21.266 -22.843 1.00 42.17  ? 489  LEU A CD1 1 
ATOM   1464 C  CD2 . LEU A 1 226 ? -22.290 -20.877 -25.133 1.00 41.93  ? 489  LEU A CD2 1 
ATOM   1465 N  N   . GLY A 1 227 ? -25.928 -24.933 -24.620 1.00 30.11  ? 490  GLY A N   1 
ATOM   1466 C  CA  . GLY A 1 227 ? -26.288 -26.359 -24.713 1.00 30.26  ? 490  GLY A CA  1 
ATOM   1467 C  C   . GLY A 1 227 ? -26.308 -26.879 -26.125 1.00 30.89  ? 490  GLY A C   1 
ATOM   1468 O  O   . GLY A 1 227 ? -26.117 -28.127 -26.342 1.00 29.40  ? 490  GLY A O   1 
ATOM   1469 N  N   . PHE A 1 228 ? -26.530 -25.980 -27.091 0.41 31.05  ? 491  PHE A N   1 
ATOM   1470 C  CA  . PHE A 1 228 ? -26.558 -26.307 -28.542 0.41 31.86  ? 491  PHE A CA  1 
ATOM   1471 C  C   . PHE A 1 228 ? -25.286 -27.069 -28.923 0.41 29.95  ? 491  PHE A C   1 
ATOM   1472 O  O   . PHE A 1 228 ? -25.379 -27.964 -29.785 0.41 30.88  ? 491  PHE A O   1 
ATOM   1473 C  CB  . PHE A 1 228 ? -26.747 -25.058 -29.407 0.41 30.97  ? 491  PHE A CB  1 
ATOM   1474 C  CG  . PHE A 1 228 ? -25.580 -24.108 -29.456 0.41 29.15  ? 491  PHE A CG  1 
ATOM   1475 C  CD1 . PHE A 1 228 ? -25.444 -23.096 -28.520 0.41 31.33  ? 491  PHE A CD1 1 
ATOM   1476 C  CD2 . PHE A 1 228 ? -24.622 -24.222 -30.446 0.41 30.46  ? 491  PHE A CD2 1 
ATOM   1477 C  CE1 . PHE A 1 228 ? -24.368 -22.222 -28.570 0.41 31.21  ? 491  PHE A CE1 1 
ATOM   1478 C  CE2 . PHE A 1 228 ? -23.542 -23.354 -30.493 0.41 31.15  ? 491  PHE A CE2 1 
ATOM   1479 C  CZ  . PHE A 1 228 ? -23.415 -22.356 -29.553 0.41 31.45  ? 491  PHE A CZ  1 
ATOM   1480 N  N   . LEU A 1 229 ? -24.149 -26.739 -28.300 1.00 31.15  ? 492  LEU A N   1 
ATOM   1481 C  CA  . LEU A 1 229 ? -22.839 -27.409 -28.620 1.00 30.70  ? 492  LEU A CA  1 
ATOM   1482 C  C   . LEU A 1 229 ? -22.958 -28.928 -28.496 1.00 27.27  ? 492  LEU A C   1 
ATOM   1483 O  O   . LEU A 1 229 ? -22.540 -29.674 -29.426 1.00 29.26  ? 492  LEU A O   1 
ATOM   1484 C  CB  . LEU A 1 229 ? -21.740 -26.824 -27.736 1.00 32.43  ? 492  LEU A CB  1 
ATOM   1485 C  CG  . LEU A 1 229 ? -21.297 -25.397 -28.091 1.00 34.62  ? 492  LEU A CG  1 
ATOM   1486 C  CD1 . LEU A 1 229 ? -20.348 -24.930 -27.035 1.00 34.04  ? 492  LEU A CD1 1 
ATOM   1487 C  CD2 . LEU A 1 229 ? -20.676 -25.303 -29.471 1.00 32.37  ? 492  LEU A CD2 1 
ATOM   1488 N  N   . ASN A 1 230 ? -23.554 -29.423 -27.412 0.41 29.05  ? 493  ASN A N   1 
ATOM   1489 C  CA  . ASN A 1 230 ? -23.795 -30.884 -27.267 0.41 30.02  ? 493  ASN A CA  1 
ATOM   1490 C  C   . ASN A 1 230 ? -25.109 -31.293 -27.949 0.41 30.94  ? 493  ASN A C   1 
ATOM   1491 O  O   . ASN A 1 230 ? -25.096 -32.307 -28.678 0.41 29.27  ? 493  ASN A O   1 
ATOM   1492 C  CB  . ASN A 1 230 ? -23.807 -31.349 -25.815 0.41 32.22  ? 493  ASN A CB  1 
ATOM   1493 C  CG  . ASN A 1 230 ? -23.820 -32.860 -25.745 0.41 33.21  ? 493  ASN A CG  1 
ATOM   1494 O  OD1 . ASN A 1 230 ? -24.862 -33.472 -25.514 0.41 32.95  ? 493  ASN A OD1 1 
ATOM   1495 N  ND2 . ASN A 1 230 ? -22.678 -33.467 -26.022 0.41 33.08  ? 493  ASN A ND2 1 
ATOM   1496 N  N   . GLU A 1 231 ? -26.200 -30.546 -27.731 0.41 32.25  ? 494  GLU A N   1 
ATOM   1497 C  CA  . GLU A 1 231 ? -27.563 -30.901 -28.224 0.41 31.81  ? 494  GLU A CA  1 
ATOM   1498 C  C   . GLU A 1 231 ? -27.563 -31.059 -29.752 0.41 30.21  ? 494  GLU A C   1 
ATOM   1499 O  O   . GLU A 1 231 ? -28.289 -31.949 -30.245 0.41 28.86  ? 494  GLU A O   1 
ATOM   1500 C  CB  . GLU A 1 231 ? -28.589 -29.841 -27.808 0.41 34.48  ? 494  GLU A CB  1 
ATOM   1501 C  CG  . GLU A 1 231 ? -28.879 -29.818 -26.316 0.41 34.62  ? 494  GLU A CG  1 
ATOM   1502 C  CD  . GLU A 1 231 ? -29.755 -30.945 -25.786 0.41 36.33  ? 494  GLU A CD  1 
ATOM   1503 O  OE1 . GLU A 1 231 ? -30.656 -31.407 -26.519 0.41 35.00  ? 494  GLU A OE1 1 
ATOM   1504 O  OE2 . GLU A 1 231 ? -29.535 -31.349 -24.623 0.41 37.01  ? 494  GLU A OE2 1 
ATOM   1505 N  N   . ASP A 1 232 ? -26.787 -30.236 -30.471 0.41 29.26  ? 495  ASP A N   1 
ATOM   1506 C  CA  . ASP A 1 232 ? -26.706 -30.241 -31.956 0.41 28.89  ? 495  ASP A CA  1 
ATOM   1507 C  C   . ASP A 1 232 ? -25.407 -30.924 -32.426 0.41 30.42  ? 495  ASP A C   1 
ATOM   1508 O  O   . ASP A 1 232 ? -25.129 -30.879 -33.646 0.41 27.88  ? 495  ASP A O   1 
ATOM   1509 C  CB  . ASP A 1 232 ? -26.840 -28.817 -32.516 0.41 29.76  ? 495  ASP A CB  1 
ATOM   1510 C  CG  . ASP A 1 232 ? -28.230 -28.208 -32.371 0.41 29.47  ? 495  ASP A CG  1 
ATOM   1511 O  OD1 . ASP A 1 232 ? -29.175 -28.979 -32.168 0.41 26.77  ? 495  ASP A OD1 1 
ATOM   1512 O  OD2 . ASP A 1 232 ? -28.351 -26.964 -32.479 0.41 27.66  ? 495  ASP A OD2 1 
ATOM   1513 N  N   . HIS A 1 233 ? -24.655 -31.577 -31.528 1.00 30.25  ? 496  HIS A N   1 
ATOM   1514 C  CA  . HIS A 1 233 ? -23.524 -32.456 -31.942 1.00 30.72  ? 496  HIS A CA  1 
ATOM   1515 C  C   . HIS A 1 233 ? -22.469 -31.666 -32.722 1.00 24.41  ? 496  HIS A C   1 
ATOM   1516 O  O   . HIS A 1 233 ? -21.973 -32.165 -33.744 1.00 29.60  ? 496  HIS A O   1 
ATOM   1517 C  CB  . HIS A 1 233 ? -24.050 -33.635 -32.762 1.00 34.99  ? 496  HIS A CB  1 
ATOM   1518 C  CG  . HIS A 1 233 ? -25.169 -34.354 -32.106 1.00 41.92  ? 496  HIS A CG  1 
ATOM   1519 N  ND1 . HIS A 1 233 ? -25.000 -35.047 -30.945 1.00 45.86  ? 496  HIS A ND1 1 
ATOM   1520 C  CD2 . HIS A 1 233 ? -26.499 -34.413 -32.417 1.00 46.24  ? 496  HIS A CD2 1 
ATOM   1521 C  CE1 . HIS A 1 233 ? -26.177 -35.556 -30.566 1.00 45.51  ? 496  HIS A CE1 1 
ATOM   1522 N  NE2 . HIS A 1 233 ? -27.100 -35.194 -31.469 1.00 44.87  ? 496  HIS A NE2 1 
ATOM   1523 N  N   . TRP A 1 234 ? -22.047 -30.540 -32.189 1.00 24.16  ? 497  TRP A N   1 
ATOM   1524 C  CA  . TRP A 1 234 ? -20.981 -29.722 -32.831 1.00 25.11  ? 497  TRP A CA  1 
ATOM   1525 C  C   . TRP A 1 234 ? -19.634 -30.494 -32.923 1.00 27.25  ? 497  TRP A C   1 
ATOM   1526 O  O   . TRP A 1 234 ? -18.847 -30.272 -33.872 1.00 27.03  ? 497  TRP A O   1 
ATOM   1527 C  CB  . TRP A 1 234 ? -20.819 -28.375 -32.119 1.00 26.10  ? 497  TRP A CB  1 
ATOM   1528 C  CG  . TRP A 1 234 ? -21.812 -27.357 -32.609 1.00 33.06  ? 497  TRP A CG  1 
ATOM   1529 C  CD1 . TRP A 1 234 ? -23.163 -27.569 -32.689 1.00 31.10  ? 497  TRP A CD1 1 
ATOM   1530 C  CD2 . TRP A 1 234 ? -21.573 -26.074 -33.215 1.00 28.98  ? 497  TRP A CD2 1 
ATOM   1531 N  NE1 . TRP A 1 234 ? -23.775 -26.466 -33.209 1.00 34.74  ? 497  TRP A NE1 1 
ATOM   1532 C  CE2 . TRP A 1 234 ? -22.851 -25.539 -33.545 1.00 28.68  ? 497  TRP A CE2 1 
ATOM   1533 C  CE3 . TRP A 1 234 ? -20.442 -25.277 -33.431 1.00 29.51  ? 497  TRP A CE3 1 
ATOM   1534 C  CZ2 . TRP A 1 234 ? -23.024 -24.279 -34.099 1.00 31.96  ? 497  TRP A CZ2 1 
ATOM   1535 C  CZ3 . TRP A 1 234 ? -20.608 -24.059 -34.048 1.00 33.06  ? 497  TRP A CZ3 1 
ATOM   1536 C  CH2 . TRP A 1 234 ? -21.884 -23.557 -34.371 1.00 31.78  ? 497  TRP A CH2 1 
ATOM   1537 N  N   . PHE A 1 235 ? -19.363 -31.350 -31.938 0.41 26.90  ? 498  PHE A N   1 
ATOM   1538 C  CA  . PHE A 1 235 ? -18.077 -32.089 -31.797 0.41 26.87  ? 498  PHE A CA  1 
ATOM   1539 C  C   . PHE A 1 235 ? -18.215 -33.538 -32.281 0.41 28.86  ? 498  PHE A C   1 
ATOM   1540 O  O   . PHE A 1 235 ? -17.354 -34.368 -31.917 0.41 27.08  ? 498  PHE A O   1 
ATOM   1541 C  CB  . PHE A 1 235 ? -17.602 -31.974 -30.349 0.41 25.61  ? 498  PHE A CB  1 
ATOM   1542 C  CG  . PHE A 1 235 ? -17.296 -30.553 -29.965 0.41 25.46  ? 498  PHE A CG  1 
ATOM   1543 C  CD1 . PHE A 1 235 ? -16.239 -29.888 -30.564 0.41 24.95  ? 498  PHE A CD1 1 
ATOM   1544 C  CD2 . PHE A 1 235 ? -18.092 -29.861 -29.064 0.41 24.82  ? 498  PHE A CD2 1 
ATOM   1545 C  CE1 . PHE A 1 235 ? -15.958 -28.570 -30.251 0.41 26.15  ? 498  PHE A CE1 1 
ATOM   1546 C  CE2 . PHE A 1 235 ? -17.811 -28.537 -28.755 0.41 26.27  ? 498  PHE A CE2 1 
ATOM   1547 C  CZ  . PHE A 1 235 ? -16.745 -27.896 -29.348 0.41 26.54  ? 498  PHE A CZ  1 
ATOM   1548 N  N   . SER A 1 236 ? -19.246 -33.840 -33.081 0.41 29.36  ? 499  SER A N   1 
ATOM   1549 C  CA  . SER A 1 236 ? -19.360 -35.099 -33.865 0.41 29.42  ? 499  SER A CA  1 
ATOM   1550 C  C   . SER A 1 236 ? -18.166 -35.216 -34.816 0.41 29.16  ? 499  SER A C   1 
ATOM   1551 O  O   . SER A 1 236 ? -17.661 -34.169 -35.256 0.41 27.69  ? 499  SER A O   1 
ATOM   1552 C  CB  . SER A 1 236 ? -20.646 -35.140 -34.639 0.41 30.51  ? 499  SER A CB  1 
ATOM   1553 O  OG  . SER A 1 236 ? -20.716 -34.055 -35.559 0.41 29.94  ? 499  SER A OG  1 
ATOM   1554 N  N   . ARG A 1 237 ? -17.770 -36.436 -35.180 0.41 27.57  ? 500  ARG A N   1 
ATOM   1555 C  CA  . ARG A 1 237 ? -16.690 -36.661 -36.169 0.41 27.74  ? 500  ARG A CA  1 
ATOM   1556 C  C   . ARG A 1 237 ? -17.104 -36.112 -37.544 0.41 28.14  ? 500  ARG A C   1 
ATOM   1557 O  O   . ARG A 1 237 ? -16.198 -35.696 -38.297 0.41 26.69  ? 500  ARG A O   1 
ATOM   1558 C  CB  . ARG A 1 237 ? -16.280 -38.131 -36.240 0.41 28.38  ? 500  ARG A CB  1 
ATOM   1559 C  CG  . ARG A 1 237 ? -14.885 -38.322 -36.815 0.41 28.19  ? 500  ARG A CG  1 
ATOM   1560 C  CD  . ARG A 1 237 ? -14.191 -39.578 -36.331 0.41 27.74  ? 500  ARG A CD  1 
ATOM   1561 N  NE  . ARG A 1 237 ? -12.796 -39.590 -36.745 0.41 26.98  ? 500  ARG A NE  1 
ATOM   1562 C  CZ  . ARG A 1 237 ? -11.808 -38.940 -36.134 0.41 26.56  ? 500  ARG A CZ  1 
ATOM   1563 N  NH1 . ARG A 1 237 ? -12.046 -38.198 -35.064 0.41 25.44  ? 500  ARG A NH1 1 
ATOM   1564 N  NH2 . ARG A 1 237 ? -10.578 -39.028 -36.611 0.41 27.48  ? 500  ARG A NH2 1 
ATOM   1565 N  N   . GLU A 1 238 ? -18.407 -36.049 -37.853 0.41 26.93  ? 501  GLU A N   1 
ATOM   1566 C  CA  . GLU A 1 238 ? -18.895 -35.507 -39.155 0.41 27.48  ? 501  GLU A CA  1 
ATOM   1567 C  C   . GLU A 1 238 ? -18.641 -33.998 -39.205 0.41 26.40  ? 501  GLU A C   1 
ATOM   1568 O  O   . GLU A 1 238 ? -18.054 -33.540 -40.180 0.41 28.91  ? 501  GLU A O   1 
ATOM   1569 C  CB  . GLU A 1 238 ? -20.389 -35.764 -39.381 0.41 29.19  ? 501  GLU A CB  1 
ATOM   1570 C  CG  . GLU A 1 238 ? -20.898 -35.173 -40.687 0.41 29.62  ? 501  GLU A CG  1 
ATOM   1571 C  CD  . GLU A 1 238 ? -22.408 -35.106 -40.787 0.41 31.97  ? 501  GLU A CD  1 
ATOM   1572 O  OE1 . GLU A 1 238 ? -23.019 -34.405 -39.957 0.41 37.80  ? 501  GLU A OE1 1 
ATOM   1573 O  OE2 . GLU A 1 238 ? -22.965 -35.767 -41.669 0.41 30.46  ? 501  GLU A OE2 1 
ATOM   1574 N  N   . ASN A 1 239 ? -19.055 -33.259 -38.180 0.41 26.17  ? 502  ASN A N   1 
ATOM   1575 C  CA  . ASN A 1 239 ? -18.951 -31.779 -38.174 0.41 27.42  ? 502  ASN A CA  1 
ATOM   1576 C  C   . ASN A 1 239 ? -17.535 -31.294 -37.829 0.41 26.29  ? 502  ASN A C   1 
ATOM   1577 O  O   . ASN A 1 239 ? -17.211 -30.198 -38.284 0.41 26.58  ? 502  ASN A O   1 
ATOM   1578 C  CB  . ASN A 1 239 ? -19.930 -31.102 -37.213 0.41 26.34  ? 502  ASN A CB  1 
ATOM   1579 C  CG  . ASN A 1 239 ? -20.011 -29.623 -37.524 0.41 26.91  ? 502  ASN A CG  1 
ATOM   1580 O  OD1 . ASN A 1 239 ? -20.187 -29.265 -38.695 0.41 24.25  ? 502  ASN A OD1 1 
ATOM   1581 N  ND2 . ASN A 1 239 ? -19.811 -28.775 -36.518 0.41 23.93  ? 502  ASN A ND2 1 
ATOM   1582 N  N   . SER A 1 240 ? -16.764 -32.047 -37.030 0.41 26.45  ? 503  SER A N   1 
ATOM   1583 C  CA  . SER A 1 240 ? -15.487 -31.607 -36.392 0.41 26.52  ? 503  SER A CA  1 
ATOM   1584 C  C   . SER A 1 240 ? -14.257 -32.286 -37.022 0.41 26.17  ? 503  SER A C   1 
ATOM   1585 O  O   . SER A 1 240 ? -13.201 -31.651 -37.017 0.41 26.87  ? 503  SER A O   1 
ATOM   1586 C  CB  . SER A 1 240 ? -15.510 -31.869 -34.901 0.41 27.33  ? 503  SER A CB  1 
ATOM   1587 O  OG  . SER A 1 240 ? -15.451 -33.270 -34.629 0.41 23.71  ? 503  SER A OG  1 
ATOM   1588 N  N   . LEU A 1 241 ? -14.384 -33.533 -37.482 0.41 26.74  ? 504  LEU A N   1 
ATOM   1589 C  CA  . LEU A 1 241 ? -13.321 -34.363 -38.130 0.41 27.79  ? 504  LEU A CA  1 
ATOM   1590 C  C   . LEU A 1 241 ? -12.402 -34.992 -37.073 0.41 26.34  ? 504  LEU A C   1 
ATOM   1591 O  O   . LEU A 1 241 ? -12.038 -36.179 -37.262 0.41 25.80  ? 504  LEU A O   1 
ATOM   1592 C  CB  . LEU A 1 241 ? -12.514 -33.529 -39.129 0.41 27.38  ? 504  LEU A CB  1 
ATOM   1593 C  CG  . LEU A 1 241 ? -13.290 -33.018 -40.344 0.41 29.19  ? 504  LEU A CG  1 
ATOM   1594 C  CD1 . LEU A 1 241 ? -12.584 -31.826 -40.988 0.41 30.46  ? 504  LEU A CD1 1 
ATOM   1595 C  CD2 . LEU A 1 241 ? -13.483 -34.131 -41.356 0.41 29.95  ? 504  LEU A CD2 1 
ATOM   1596 N  N   . SER A 1 242 ? -12.036 -34.236 -36.030 0.41 24.88  ? 505  SER A N   1 
ATOM   1597 C  CA  . SER A 1 242 ? -11.167 -34.679 -34.908 0.41 25.35  ? 505  SER A CA  1 
ATOM   1598 C  C   . SER A 1 242 ? -11.997 -35.196 -33.740 0.41 24.09  ? 505  SER A C   1 
ATOM   1599 O  O   . SER A 1 242 ? -11.443 -35.959 -32.942 0.41 22.85  ? 505  SER A O   1 
ATOM   1600 C  CB  . SER A 1 242 ? -10.258 -33.568 -34.430 0.41 25.86  ? 505  SER A CB  1 
ATOM   1601 O  OG  . SER A 1 242 ? -9.588  -32.975 -35.523 0.41 27.56  ? 505  SER A OG  1 
ATOM   1602 N  N   . GLY A 1 243 ? -13.243 -34.737 -33.592 1.00 24.05  ? 506  GLY A N   1 
ATOM   1603 C  CA  . GLY A 1 243 ? -14.056 -35.114 -32.429 1.00 23.04  ? 506  GLY A CA  1 
ATOM   1604 C  C   . GLY A 1 243 ? -14.627 -36.500 -32.550 1.00 22.94  ? 506  GLY A C   1 
ATOM   1605 O  O   . GLY A 1 243 ? -14.565 -37.102 -33.619 1.00 24.72  ? 506  GLY A O   1 
ATOM   1606 N  N   . VAL A 1 244 ? -15.161 -37.026 -31.453 0.41 23.21  ? 507  VAL A N   1 
ATOM   1607 C  CA  . VAL A 1 244 ? -15.794 -38.376 -31.403 0.41 25.85  ? 507  VAL A CA  1 
ATOM   1608 C  C   . VAL A 1 244 ? -17.115 -38.307 -30.623 0.41 26.27  ? 507  VAL A C   1 
ATOM   1609 O  O   . VAL A 1 244 ? -17.667 -39.378 -30.295 0.41 25.04  ? 507  VAL A O   1 
ATOM   1610 C  CB  . VAL A 1 244 ? -14.836 -39.419 -30.788 0.41 25.32  ? 507  VAL A CB  1 
ATOM   1611 C  CG1 . VAL A 1 244 ? -13.700 -39.747 -31.738 0.41 25.14  ? 507  VAL A CG1 1 
ATOM   1612 C  CG2 . VAL A 1 244 ? -14.300 -38.975 -29.434 0.41 26.08  ? 507  VAL A CG2 1 
ATOM   1613 N  N   . GLU A 1 245 ? -17.626 -37.104 -30.347 0.41 28.61  ? 508  GLU A N   1 
ATOM   1614 C  CA  . GLU A 1 245 ? -18.790 -36.932 -29.435 0.41 30.03  ? 508  GLU A CA  1 
ATOM   1615 C  C   . GLU A 1 245 ? -19.968 -37.718 -30.029 0.41 28.69  ? 508  GLU A C   1 
ATOM   1616 O  O   . GLU A 1 245 ? -20.187 -37.629 -31.245 0.41 29.09  ? 508  GLU A O   1 
ATOM   1617 C  CB  . GLU A 1 245 ? -19.058 -35.446 -29.187 0.41 31.81  ? 508  GLU A CB  1 
ATOM   1618 C  CG  . GLU A 1 245 ? -19.985 -35.186 -28.012 0.41 33.46  ? 508  GLU A CG  1 
ATOM   1619 C  CD  . GLU A 1 245 ? -21.453 -35.332 -28.370 0.41 37.25  ? 508  GLU A CD  1 
ATOM   1620 O  OE1 . GLU A 1 245 ? -21.928 -34.549 -29.237 0.41 37.21  ? 508  GLU A OE1 1 
ATOM   1621 O  OE2 . GLU A 1 245 ? -22.114 -36.231 -27.798 0.41 38.80  ? 508  GLU A OE2 1 
ATOM   1622 N  N   . GLY A 1 246 ? -20.619 -38.540 -29.205 1.00 31.78  ? 509  GLY A N   1 
ATOM   1623 C  CA  . GLY A 1 246 ? -21.719 -39.453 -29.638 1.00 32.69  ? 509  GLY A CA  1 
ATOM   1624 C  C   . GLY A 1 246 ? -21.265 -40.730 -30.312 1.00 33.69  ? 509  GLY A C   1 
ATOM   1625 O  O   . GLY A 1 246 ? -22.113 -41.479 -30.746 1.00 32.63  ? 509  GLY A O   1 
ATOM   1626 N  N   . GLU A 1 247 ? -19.950 -40.966 -30.418 0.41 32.57  ? 510  GLU A N   1 
ATOM   1627 C  CA  . GLU A 1 247 ? -19.442 -42.117 -31.206 0.41 34.04  ? 510  GLU A CA  1 
ATOM   1628 C  C   . GLU A 1 247 ? -19.856 -43.399 -30.490 0.41 35.62  ? 510  GLU A C   1 
ATOM   1629 O  O   . GLU A 1 247 ? -20.668 -44.157 -31.065 0.41 39.60  ? 510  GLU A O   1 
ATOM   1630 C  CB  . GLU A 1 247 ? -17.931 -42.071 -31.451 0.41 33.14  ? 510  GLU A CB  1 
ATOM   1631 C  CG  . GLU A 1 247 ? -17.565 -41.387 -32.756 0.41 31.94  ? 510  GLU A CG  1 
ATOM   1632 C  CD  . GLU A 1 247 ? -18.288 -41.950 -33.965 0.41 32.61  ? 510  GLU A CD  1 
ATOM   1633 O  OE1 . GLU A 1 247 ? -18.693 -43.116 -33.904 0.41 33.58  ? 510  GLU A OE1 1 
ATOM   1634 O  OE2 . GLU A 1 247 ? -18.480 -41.212 -34.951 0.41 33.76  ? 510  GLU A OE2 1 
ATOM   1635 N  N   . GLY A 1 248 ? -19.388 -43.589 -29.261 1.00 34.79  ? 511  GLY A N   1 
ATOM   1636 C  CA  . GLY A 1 248 ? -19.550 -44.912 -28.596 1.00 34.56  ? 511  GLY A CA  1 
ATOM   1637 C  C   . GLY A 1 248 ? -18.239 -45.735 -28.584 1.00 33.52  ? 511  GLY A C   1 
ATOM   1638 O  O   . GLY A 1 248 ? -17.423 -45.677 -29.539 1.00 28.67  ? 511  GLY A O   1 
ATOM   1639 N  N   A LEU A 1 249 ? -18.057 -46.524 -27.532 0.20 31.82  ? 512  LEU A N   1 
ATOM   1640 N  N   B LEU A 1 249 ? -18.024 -46.480 -27.493 0.21 32.75  ? 512  LEU A N   1 
ATOM   1641 C  CA  A LEU A 1 249 ? -16.787 -47.228 -27.244 0.20 31.88  ? 512  LEU A CA  1 
ATOM   1642 C  CA  B LEU A 1 249 ? -16.785 -47.265 -27.243 0.21 33.32  ? 512  LEU A CA  1 
ATOM   1643 C  C   A LEU A 1 249 ? -16.539 -48.307 -28.302 0.20 32.73  ? 512  LEU A C   1 
ATOM   1644 C  C   B LEU A 1 249 ? -16.536 -48.204 -28.414 0.21 33.24  ? 512  LEU A C   1 
ATOM   1645 O  O   A LEU A 1 249 ? -15.375 -48.637 -28.531 0.20 36.49  ? 512  LEU A O   1 
ATOM   1646 O  O   B LEU A 1 249 ? -15.375 -48.342 -28.809 0.21 35.26  ? 512  LEU A O   1 
ATOM   1647 C  CB  A LEU A 1 249 ? -16.891 -47.795 -25.827 0.20 32.44  ? 512  LEU A CB  1 
ATOM   1648 C  CB  B LEU A 1 249 ? -16.904 -48.080 -25.951 0.21 35.73  ? 512  LEU A CB  1 
ATOM   1649 C  CG  A LEU A 1 249 ? -15.628 -48.422 -25.262 0.20 29.22  ? 512  LEU A CG  1 
ATOM   1650 C  CG  B LEU A 1 249 ? -16.034 -47.628 -24.786 0.21 33.52  ? 512  LEU A CG  1 
ATOM   1651 C  CD1 A LEU A 1 249 ? -14.503 -47.399 -25.187 0.20 29.19  ? 512  LEU A CD1 1 
ATOM   1652 C  CD1 B LEU A 1 249 ? -16.198 -48.582 -23.617 0.21 32.40  ? 512  LEU A CD1 1 
ATOM   1653 C  CD2 A LEU A 1 249 ? -15.915 -49.013 -23.896 0.20 28.66  ? 512  LEU A CD2 1 
ATOM   1654 C  CD2 B LEU A 1 249 ? -14.572 -47.526 -25.197 0.21 33.19  ? 512  LEU A CD2 1 
ATOM   1655 N  N   . HIS A 1 250 ? -17.598 -48.819 -28.932 1.00 34.04  ? 513  HIS A N   1 
ATOM   1656 C  CA  . HIS A 1 250 ? -17.513 -49.766 -30.058 1.00 30.16  ? 513  HIS A CA  1 
ATOM   1657 C  C   . HIS A 1 250 ? -17.094 -49.137 -31.403 1.00 31.24  ? 513  HIS A C   1 
ATOM   1658 O  O   . HIS A 1 250 ? -16.911 -49.890 -32.365 1.00 31.96  ? 513  HIS A O   1 
ATOM   1659 C  CB  . HIS A 1 250 ? -18.862 -50.484 -30.277 1.00 32.88  ? 513  HIS A CB  1 
ATOM   1660 C  CG  . HIS A 1 250 ? -19.987 -49.565 -30.587 1.00 31.64  ? 513  HIS A CG  1 
ATOM   1661 N  ND1 . HIS A 1 250 ? -20.478 -48.697 -29.632 1.00 33.14  ? 513  HIS A ND1 1 
ATOM   1662 C  CD2 . HIS A 1 250 ? -20.687 -49.352 -31.731 1.00 31.80  ? 513  HIS A CD2 1 
ATOM   1663 C  CE1 . HIS A 1 250 ? -21.475 -48.010 -30.174 1.00 32.97  ? 513  HIS A CE1 1 
ATOM   1664 N  NE2 . HIS A 1 250 ? -21.622 -48.399 -31.460 1.00 33.13  ? 513  HIS A NE2 1 
ATOM   1665 N  N   . LYS A 1 251 ? -17.003 -47.802 -31.449 0.41 28.28  ? 514  LYS A N   1 
ATOM   1666 C  CA  . LYS A 1 251 ? -16.586 -47.014 -32.637 0.41 26.76  ? 514  LYS A CA  1 
ATOM   1667 C  C   . LYS A 1 251 ? -15.104 -46.645 -32.505 0.41 25.36  ? 514  LYS A C   1 
ATOM   1668 O  O   . LYS A 1 251 ? -14.378 -46.705 -33.529 0.41 24.23  ? 514  LYS A O   1 
ATOM   1669 C  CB  . LYS A 1 251 ? -17.436 -45.744 -32.749 0.41 27.22  ? 514  LYS A CB  1 
ATOM   1670 C  CG  . LYS A 1 251 ? -18.911 -45.983 -33.061 0.41 29.45  ? 514  LYS A CG  1 
ATOM   1671 C  CD  . LYS A 1 251 ? -19.200 -46.122 -34.537 0.41 30.57  ? 514  LYS A CD  1 
ATOM   1672 C  CE  . LYS A 1 251 ? -20.647 -45.836 -34.882 0.41 30.23  ? 514  LYS A CE  1 
ATOM   1673 N  NZ  . LYS A 1 251 ? -20.848 -45.709 -36.346 0.41 32.21  ? 514  LYS A NZ  1 
ATOM   1674 N  N   . LEU A 1 252 ? -14.677 -46.308 -31.284 1.00 24.12  ? 515  LEU A N   1 
ATOM   1675 C  CA  . LEU A 1 252 ? -13.391 -45.604 -31.048 1.00 24.79  ? 515  LEU A CA  1 
ATOM   1676 C  C   . LEU A 1 252 ? -12.214 -46.404 -31.614 1.00 25.45  ? 515  LEU A C   1 
ATOM   1677 O  O   . LEU A 1 252 ? -11.275 -45.751 -32.200 1.00 24.20  ? 515  LEU A O   1 
ATOM   1678 C  CB  . LEU A 1 252 ? -13.250 -45.327 -29.580 1.00 22.94  ? 515  LEU A CB  1 
ATOM   1679 C  CG  . LEU A 1 252 ? -14.278 -44.381 -29.001 1.00 23.93  ? 515  LEU A CG  1 
ATOM   1680 C  CD1 . LEU A 1 252 ? -13.902 -44.065 -27.576 1.00 27.68  ? 515  LEU A CD1 1 
ATOM   1681 C  CD2 . LEU A 1 252 ? -14.378 -43.086 -29.780 1.00 25.60  ? 515  LEU A CD2 1 
ATOM   1682 N  N   . GLY A 1 253 ? -12.225 -47.734 -31.510 1.00 21.45  ? 516  GLY A N   1 
ATOM   1683 C  CA  . GLY A 1 253 ? -11.090 -48.514 -32.040 1.00 25.18  ? 516  GLY A CA  1 
ATOM   1684 C  C   . GLY A 1 253 ? -11.025 -48.399 -33.563 1.00 27.67  ? 516  GLY A C   1 
ATOM   1685 O  O   . GLY A 1 253 ? -9.903  -48.265 -34.131 1.00 25.69  ? 516  GLY A O   1 
ATOM   1686 N  N   . TYR A 1 254 ? -12.169 -48.479 -34.219 1.00 25.88  ? 517  TYR A N   1 
ATOM   1687 C  CA  . TYR A 1 254 ? -12.253 -48.370 -35.701 1.00 26.72  ? 517  TYR A CA  1 
ATOM   1688 C  C   . TYR A 1 254 ? -11.763 -46.987 -36.152 1.00 23.29  ? 517  TYR A C   1 
ATOM   1689 O  O   . TYR A 1 254 ? -11.050 -46.878 -37.146 1.00 25.15  ? 517  TYR A O   1 
ATOM   1690 C  CB  . TYR A 1 254 ? -13.670 -48.612 -36.196 1.00 27.32  ? 517  TYR A CB  1 
ATOM   1691 C  CG  . TYR A 1 254 ? -14.124 -50.044 -36.215 1.00 25.36  ? 517  TYR A CG  1 
ATOM   1692 C  CD1 . TYR A 1 254 ? -13.557 -50.977 -37.093 1.00 27.13  ? 517  TYR A CD1 1 
ATOM   1693 C  CD2 . TYR A 1 254 ? -15.095 -50.477 -35.336 1.00 24.65  ? 517  TYR A CD2 1 
ATOM   1694 C  CE1 . TYR A 1 254 ? -14.017 -52.300 -37.137 1.00 26.21  ? 517  TYR A CE1 1 
ATOM   1695 C  CE2 . TYR A 1 254 ? -15.564 -51.782 -35.362 1.00 25.55  ? 517  TYR A CE2 1 
ATOM   1696 C  CZ  . TYR A 1 254 ? -15.048 -52.693 -36.282 1.00 26.19  ? 517  TYR A CZ  1 
ATOM   1697 O  OH  . TYR A 1 254 ? -15.536 -53.989 -36.300 1.00 27.70  ? 517  TYR A OH  1 
ATOM   1698 N  N   . ILE A 1 255 ? -12.067 -45.972 -35.383 1.00 25.60  ? 518  ILE A N   1 
ATOM   1699 C  CA  . ILE A 1 255 ? -11.648 -44.599 -35.658 1.00 25.00  ? 518  ILE A CA  1 
ATOM   1700 C  C   . ILE A 1 255 ? -10.123 -44.498 -35.576 1.00 26.66  ? 518  ILE A C   1 
ATOM   1701 O  O   . ILE A 1 255 ? -9.532  -43.910 -36.509 1.00 29.83  ? 518  ILE A O   1 
ATOM   1702 C  CB  . ILE A 1 255 ? -12.387 -43.589 -34.765 1.00 26.53  ? 518  ILE A CB  1 
ATOM   1703 C  CG1 . ILE A 1 255 ? -13.844 -43.453 -35.221 1.00 24.87  ? 518  ILE A CG1 1 
ATOM   1704 C  CG2 . ILE A 1 255 ? -11.671 -42.225 -34.723 1.00 25.27  ? 518  ILE A CG2 1 
ATOM   1705 C  CD1 . ILE A 1 255 ? -14.716 -42.746 -34.183 1.00 29.19  ? 518  ILE A CD1 1 
ATOM   1706 N  N   . LEU A 1 256 ? -9.502  -45.065 -34.535 0.41 26.83  ? 519  LEU A N   1 
ATOM   1707 C  CA  . LEU A 1 256 ? -8.028  -45.001 -34.346 0.41 26.09  ? 519  LEU A CA  1 
ATOM   1708 C  C   . LEU A 1 256 ? -7.325  -45.847 -35.416 0.41 27.53  ? 519  LEU A C   1 
ATOM   1709 O  O   . LEU A 1 256 ? -6.180  -45.482 -35.784 0.41 26.96  ? 519  LEU A O   1 
ATOM   1710 C  CB  . LEU A 1 256 ? -7.654  -45.461 -32.936 0.41 25.26  ? 519  LEU A CB  1 
ATOM   1711 C  CG  . LEU A 1 256 ? -8.217  -44.619 -31.794 0.41 25.78  ? 519  LEU A CG  1 
ATOM   1712 C  CD1 . LEU A 1 256 ? -7.851  -45.229 -30.447 0.41 24.96  ? 519  LEU A CD1 1 
ATOM   1713 C  CD2 . LEU A 1 256 ? -7.743  -43.175 -31.875 0.41 25.98  ? 519  LEU A CD2 1 
ATOM   1714 N  N   . ARG A 1 257 ? -7.965  -46.929 -35.887 1.00 26.20  ? 520  ARG A N   1 
ATOM   1715 C  CA  . ARG A 1 257 ? -7.421  -47.749 -37.007 1.00 28.70  ? 520  ARG A CA  1 
ATOM   1716 C  C   . ARG A 1 257 ? -7.480  -46.898 -38.289 1.00 28.04  ? 520  ARG A C   1 
ATOM   1717 O  O   . ARG A 1 257 ? -6.512  -46.939 -39.075 1.00 27.58  ? 520  ARG A O   1 
ATOM   1718 C  CB  . ARG A 1 257 ? -8.122  -49.102 -37.152 1.00 30.51  ? 520  ARG A CB  1 
ATOM   1719 C  CG  . ARG A 1 257 ? -7.511  -49.969 -38.264 1.00 31.47  ? 520  ARG A CG  1 
ATOM   1720 C  CD  . ARG A 1 257 ? -8.209  -51.301 -38.436 1.00 28.61  ? 520  ARG A CD  1 
ATOM   1721 N  NE  . ARG A 1 257 ? -9.568  -51.145 -38.956 1.00 28.60  ? 520  ARG A NE  1 
ATOM   1722 C  CZ  . ARG A 1 257 ? -10.342 -52.143 -39.381 1.00 27.14  ? 520  ARG A CZ  1 
ATOM   1723 N  NH1 . ARG A 1 257 ? -9.940  -53.385 -39.270 1.00 29.88  ? 520  ARG A NH1 1 
ATOM   1724 N  NH2 . ARG A 1 257 ? -11.503 -51.883 -39.892 1.00 29.81  ? 520  ARG A NH2 1 
ATOM   1725 N  N   . ASP A 1 258 ? -8.531  -46.101 -38.476 1.00 26.12  ? 521  ASP A N   1 
ATOM   1726 C  CA  . ASP A 1 258 ? -8.647  -45.218 -39.700 1.00 29.59  ? 521  ASP A CA  1 
ATOM   1727 C  C   . ASP A 1 258 ? -7.531  -44.138 -39.653 1.00 28.16  ? 521  ASP A C   1 
ATOM   1728 O  O   . ASP A 1 258 ? -6.963  -43.819 -40.673 1.00 30.34  ? 521  ASP A O   1 
ATOM   1729 C  CB  . ASP A 1 258 ? -10.056 -44.614 -39.913 1.00 31.99  ? 521  ASP A CB  1 
ATOM   1730 C  CG  . ASP A 1 258 ? -11.095 -45.550 -40.560 1.00 31.87  ? 521  ASP A CG  1 
ATOM   1731 O  OD1 . ASP A 1 258 ? -10.740 -46.631 -41.026 1.00 32.04  ? 521  ASP A OD1 1 
ATOM   1732 O  OD2 . ASP A 1 258 ? -12.288 -45.217 -40.514 1.00 36.05  ? 521  ASP A OD2 1 
ATOM   1733 N  N   . VAL A 1 259 ? -7.282  -43.525 -38.521 1.00 26.97  ? 522  VAL A N   1 
ATOM   1734 C  CA  . VAL A 1 259 ? -6.181  -42.548 -38.355 1.00 28.59  ? 522  VAL A CA  1 
ATOM   1735 C  C   . VAL A 1 259 ? -4.834  -43.226 -38.705 1.00 31.54  ? 522  VAL A C   1 
ATOM   1736 O  O   . VAL A 1 259 ? -4.031  -42.626 -39.400 1.00 33.48  ? 522  VAL A O   1 
ATOM   1737 C  CB  . VAL A 1 259 ? -6.176  -41.951 -36.940 1.00 29.19  ? 522  VAL A CB  1 
ATOM   1738 C  CG1 . VAL A 1 259 ? -4.906  -41.096 -36.765 1.00 30.89  ? 522  VAL A CG1 1 
ATOM   1739 C  CG2 . VAL A 1 259 ? -7.423  -41.117 -36.699 1.00 27.89  ? 522  VAL A CG2 1 
ATOM   1740 N  N   . SER A 1 260 ? -4.620  -44.464 -38.252 0.41 29.31  ? 523  SER A N   1 
ATOM   1741 C  CA  . SER A 1 260 ? -3.381  -45.245 -38.509 0.41 29.86  ? 523  SER A CA  1 
ATOM   1742 C  C   . SER A 1 260 ? -3.093  -45.298 -40.016 0.41 30.60  ? 523  SER A C   1 
ATOM   1743 O  O   . SER A 1 260 ? -1.915  -45.132 -40.378 0.41 28.59  ? 523  SER A O   1 
ATOM   1744 C  CB  . SER A 1 260 ? -3.433  -46.631 -37.906 0.41 30.07  ? 523  SER A CB  1 
ATOM   1745 O  OG  . SER A 1 260 ? -3.961  -47.580 -38.825 0.41 32.04  ? 523  SER A OG  1 
ATOM   1746 N  N   . LYS A 1 261 ? -4.133  -45.453 -40.845 0.41 31.59  ? 524  LYS A N   1 
ATOM   1747 C  CA  . LYS A 1 261 ? -4.052  -45.661 -42.320 0.41 32.90  ? 524  LYS A CA  1 
ATOM   1748 C  C   . LYS A 1 261 ? -3.435  -44.438 -43.021 0.41 33.20  ? 524  LYS A C   1 
ATOM   1749 O  O   . LYS A 1 261 ? -3.026  -44.581 -44.196 0.41 32.67  ? 524  LYS A O   1 
ATOM   1750 C  CB  . LYS A 1 261 ? -5.440  -45.944 -42.910 0.41 35.35  ? 524  LYS A CB  1 
ATOM   1751 C  CG  . LYS A 1 261 ? -6.048  -47.284 -42.517 0.41 37.94  ? 524  LYS A CG  1 
ATOM   1752 C  CD  . LYS A 1 261 ? -7.476  -47.482 -43.004 0.41 40.58  ? 524  LYS A CD  1 
ATOM   1753 C  CE  . LYS A 1 261 ? -8.164  -48.639 -42.314 0.41 41.67  ? 524  LYS A CE  1 
ATOM   1754 N  NZ  . LYS A 1 261 ? -7.394  -49.898 -42.459 0.41 43.40  ? 524  LYS A NZ  1 
ATOM   1755 N  N   . LYS A 1 262 ? -3.395  -43.279 -42.361 0.41 32.55  ? 525  LYS A N   1 
ATOM   1756 C  CA  . LYS A 1 262 ? -2.831  -42.030 -42.935 0.41 32.88  ? 525  LYS A CA  1 
ATOM   1757 C  C   . LYS A 1 262 ? -1.303  -42.109 -42.914 0.41 33.58  ? 525  LYS A C   1 
ATOM   1758 O  O   . LYS A 1 262 ? -0.727  -42.366 -41.840 0.41 29.87  ? 525  LYS A O   1 
ATOM   1759 C  CB  . LYS A 1 262 ? -3.326  -40.810 -42.162 0.41 32.97  ? 525  LYS A CB  1 
ATOM   1760 C  CG  . LYS A 1 262 ? -4.828  -40.578 -42.265 0.41 34.22  ? 525  LYS A CG  1 
ATOM   1761 C  CD  . LYS A 1 262 ? -5.272  -39.242 -41.726 0.41 36.16  ? 525  LYS A CD  1 
ATOM   1762 C  CE  . LYS A 1 262 ? -6.709  -38.928 -42.066 0.41 37.87  ? 525  LYS A CE  1 
ATOM   1763 N  NZ  . LYS A 1 262 ? -6.882  -38.659 -43.517 0.41 40.43  ? 525  LYS A NZ  1 
ATOM   1764 N  N   . GLU A 1 263 ? -0.658  -41.877 -44.058 0.41 34.01  ? 526  GLU A N   1 
ATOM   1765 C  CA  . GLU A 1 263 ? 0.824   -41.782 -44.096 0.41 33.88  ? 526  GLU A CA  1 
ATOM   1766 C  C   . GLU A 1 263 ? 1.231   -40.688 -43.099 0.41 34.73  ? 526  GLU A C   1 
ATOM   1767 O  O   . GLU A 1 263 ? 0.554   -39.646 -43.051 0.41 33.55  ? 526  GLU A O   1 
ATOM   1768 C  CB  . GLU A 1 263 ? 1.350   -41.525 -45.510 0.41 33.64  ? 526  GLU A CB  1 
ATOM   1769 C  CG  . GLU A 1 263 ? 0.982   -42.609 -46.521 0.41 33.29  ? 526  GLU A CG  1 
ATOM   1770 C  CD  . GLU A 1 263 ? 1.583   -43.991 -46.302 0.41 34.33  ? 526  GLU A CD  1 
ATOM   1771 O  OE1 . GLU A 1 263 ? 2.788   -44.081 -45.930 0.41 33.80  ? 526  GLU A OE1 1 
ATOM   1772 O  OE2 . GLU A 1 263 ? 0.857   -44.980 -46.537 0.41 31.93  ? 526  GLU A OE2 1 
ATOM   1773 N  N   . GLY A 1 264 ? 2.276   -40.966 -42.321 1.00 35.29  ? 527  GLY A N   1 
ATOM   1774 C  CA  . GLY A 1 264 ? 2.871   -40.022 -41.367 1.00 36.80  ? 527  GLY A CA  1 
ATOM   1775 C  C   . GLY A 1 264 ? 3.774   -40.709 -40.396 1.00 34.40  ? 527  GLY A C   1 
ATOM   1776 O  O   . GLY A 1 264 ? 4.197   -41.801 -40.646 1.00 36.90  ? 527  GLY A O   1 
ATOM   1777 N  N   . GLY A 1 265 ? 4.028   -40.087 -39.265 1.00 38.48  ? 528  GLY A N   1 
ATOM   1778 C  CA  . GLY A 1 265 ? 4.899   -40.717 -38.271 1.00 35.94  ? 528  GLY A CA  1 
ATOM   1779 C  C   . GLY A 1 265 ? 4.132   -41.496 -37.207 1.00 38.88  ? 528  GLY A C   1 
ATOM   1780 O  O   . GLY A 1 265 ? 3.078   -42.050 -37.512 1.00 37.41  ? 528  GLY A O   1 
ATOM   1781 N  N   . ALA A 1 266 ? 4.712   -41.592 -36.017 1.00 30.79  ? 529  ALA A N   1 
ATOM   1782 C  CA  . ALA A 1 266 ? 4.180   -42.315 -34.855 1.00 28.58  ? 529  ALA A CA  1 
ATOM   1783 C  C   . ALA A 1 266 ? 2.814   -41.725 -34.511 1.00 29.22  ? 529  ALA A C   1 
ATOM   1784 O  O   . ALA A 1 266 ? 2.521   -40.614 -34.969 1.00 28.10  ? 529  ALA A O   1 
ATOM   1785 C  CB  . ALA A 1 266 ? 5.155   -42.201 -33.705 1.00 27.53  ? 529  ALA A CB  1 
ATOM   1786 N  N   . MET A 1 267 ? 1.997   -42.452 -33.739 1.00 27.01  ? 530  MET A N   1 
ATOM   1787 C  CA  . MET A 1 267 ? 0.804   -41.892 -33.066 1.00 26.06  ? 530  MET A CA  1 
ATOM   1788 C  C   . MET A 1 267 ? 1.223   -41.339 -31.706 1.00 24.76  ? 530  MET A C   1 
ATOM   1789 O  O   . MET A 1 267 ? 1.900   -42.018 -30.942 1.00 34.11  ? 530  MET A O   1 
ATOM   1790 C  CB  . MET A 1 267 ? -0.299  -42.975 -32.979 1.00 31.51  ? 530  MET A CB  1 
ATOM   1791 C  CG  . MET A 1 267 ? -0.713  -43.409 -34.388 1.00 31.97  ? 530  MET A CG  1 
ATOM   1792 S  SD  . MET A 1 267 ? -2.064  -44.631 -34.583 1.00 36.39  ? 530  MET A SD  1 
ATOM   1793 C  CE  . MET A 1 267 ? -3.387  -43.801 -33.732 1.00 39.12  ? 530  MET A CE  1 
ATOM   1794 N  N   . TYR A 1 268 ? 0.915   -40.085 -31.432 1.00 22.94  ? 531  TYR A N   1 
ATOM   1795 C  CA  . TYR A 1 268 ? 1.200   -39.425 -30.142 1.00 22.98  ? 531  TYR A CA  1 
ATOM   1796 C  C   . TYR A 1 268 ? -0.073  -39.351 -29.335 1.00 24.34  ? 531  TYR A C   1 
ATOM   1797 O  O   . TYR A 1 268 ? -1.169  -38.950 -29.864 1.00 27.32  ? 531  TYR A O   1 
ATOM   1798 C  CB  . TYR A 1 268 ? 1.845   -38.069 -30.426 1.00 23.42  ? 531  TYR A CB  1 
ATOM   1799 C  CG  . TYR A 1 268 ? 3.148   -38.230 -31.157 1.00 27.61  ? 531  TYR A CG  1 
ATOM   1800 C  CD1 . TYR A 1 268 ? 3.201   -38.374 -32.536 1.00 28.43  ? 531  TYR A CD1 1 
ATOM   1801 C  CD2 . TYR A 1 268 ? 4.331   -38.371 -30.451 1.00 28.10  ? 531  TYR A CD2 1 
ATOM   1802 C  CE1 . TYR A 1 268 ? 4.413   -38.602 -33.178 1.00 30.50  ? 531  TYR A CE1 1 
ATOM   1803 C  CE2 . TYR A 1 268 ? 5.533   -38.600 -31.087 1.00 31.92  ? 531  TYR A CE2 1 
ATOM   1804 C  CZ  . TYR A 1 268 ? 5.586   -38.709 -32.455 1.00 34.63  ? 531  TYR A CZ  1 
ATOM   1805 O  OH  . TYR A 1 268 ? 6.816   -38.924 -33.070 1.00 30.32  ? 531  TYR A OH  1 
ATOM   1806 N  N   . ALA A 1 269 ? 0.037   -39.640 -28.046 1.00 26.88  ? 532  ALA A N   1 
ATOM   1807 C  CA  . ALA A 1 269 ? -1.126  -39.573 -27.138 1.00 25.56  ? 532  ALA A CA  1 
ATOM   1808 C  C   . ALA A 1 269 ? -0.669  -38.958 -25.827 1.00 29.57  ? 532  ALA A C   1 
ATOM   1809 O  O   . ALA A 1 269 ? -0.683  -39.640 -24.789 1.00 31.47  ? 532  ALA A O   1 
ATOM   1810 C  CB  . ALA A 1 269 ? -1.748  -40.951 -27.002 1.00 23.75  ? 532  ALA A CB  1 
ATOM   1811 N  N   . ASP A 1 270 ? -0.278  -37.697 -25.853 1.00 27.99  ? 533  ASP A N   1 
ATOM   1812 C  CA  . ASP A 1 270 ? 0.310   -37.073 -24.644 1.00 29.01  ? 533  ASP A CA  1 
ATOM   1813 C  C   . ASP A 1 270 ? -0.837  -36.609 -23.756 1.00 32.69  ? 533  ASP A C   1 
ATOM   1814 O  O   . ASP A 1 270 ? -1.651  -35.854 -24.234 1.00 30.86  ? 533  ASP A O   1 
ATOM   1815 C  CB  . ASP A 1 270 ? 1.244   -35.912 -25.031 1.00 31.38  ? 533  ASP A CB  1 
ATOM   1816 C  CG  . ASP A 1 270 ? 2.551   -36.348 -25.700 1.00 35.24  ? 533  ASP A CG  1 
ATOM   1817 O  OD1 . ASP A 1 270 ? 2.877   -37.573 -25.639 1.00 35.09  ? 533  ASP A OD1 1 
ATOM   1818 O  OD2 . ASP A 1 270 ? 3.177   -35.501 -26.351 1.00 31.75  ? 533  ASP A OD2 1 
ATOM   1819 N  N   . ASP A 1 271 ? -0.859  -36.999 -22.495 1.00 32.90  ? 534  ASP A N   1 
ATOM   1820 C  CA  . ASP A 1 271 ? -1.795  -36.483 -21.462 1.00 38.73  ? 534  ASP A CA  1 
ATOM   1821 C  C   . ASP A 1 271 ? -1.291  -35.126 -20.968 1.00 36.25  ? 534  ASP A C   1 
ATOM   1822 O  O   . ASP A 1 271 ? -0.093  -34.940 -20.847 1.00 36.56  ? 534  ASP A O   1 
ATOM   1823 C  CB  . ASP A 1 271 ? -1.920  -37.444 -20.275 1.00 43.46  ? 534  ASP A CB  1 
ATOM   1824 C  CG  . ASP A 1 271 ? -2.962  -38.536 -20.459 1.00 57.86  ? 534  ASP A CG  1 
ATOM   1825 O  OD1 . ASP A 1 271 ? -3.838  -38.368 -21.313 1.00 64.08  ? 534  ASP A OD1 1 
ATOM   1826 O  OD2 . ASP A 1 271 ? -2.899  -39.548 -19.748 1.00 73.08  ? 534  ASP A OD2 1 
ATOM   1827 N  N   . THR A 1 272 ? -2.204  -34.191 -20.692 0.41 34.53  ? 535  THR A N   1 
ATOM   1828 C  CA  . THR A 1 272 ? -1.869  -32.875 -20.089 0.41 34.26  ? 535  THR A CA  1 
ATOM   1829 C  C   . THR A 1 272 ? -1.943  -33.006 -18.569 0.41 34.44  ? 535  THR A C   1 
ATOM   1830 O  O   . THR A 1 272 ? -2.867  -33.654 -18.081 0.41 35.94  ? 535  THR A O   1 
ATOM   1831 C  CB  . THR A 1 272 ? -2.754  -31.758 -20.644 0.41 33.53  ? 535  THR A CB  1 
ATOM   1832 O  OG1 . THR A 1 272 ? -2.606  -31.803 -22.064 0.41 33.28  ? 535  THR A OG1 1 
ATOM   1833 C  CG2 . THR A 1 272 ? -2.389  -30.386 -20.119 0.41 33.58  ? 535  THR A CG2 1 
ATOM   1834 N  N   . ALA A 1 273 ? -0.982  -32.414 -17.861 0.41 37.60  ? 536  ALA A N   1 
ATOM   1835 C  CA  . ALA A 1 273 ? -0.938  -32.356 -16.382 0.41 38.81  ? 536  ALA A CA  1 
ATOM   1836 C  C   . ALA A 1 273 ? -1.929  -31.290 -15.884 0.41 38.37  ? 536  ALA A C   1 
ATOM   1837 O  O   . ALA A 1 273 ? -1.550  -30.099 -15.820 0.41 40.23  ? 536  ALA A O   1 
ATOM   1838 C  CB  . ALA A 1 273 ? 0.481   -32.093 -15.930 0.41 38.88  ? 536  ALA A CB  1 
ATOM   1839 N  N   . GLY A 1 274 ? -3.158  -31.713 -15.570 0.41 37.54  ? 537  GLY A N   1 
ATOM   1840 C  CA  . GLY A 1 274 ? -4.236  -30.872 -15.008 0.41 37.38  ? 537  GLY A CA  1 
ATOM   1841 C  C   . GLY A 1 274 ? -4.813  -29.908 -16.032 0.41 35.65  ? 537  GLY A C   1 
ATOM   1842 O  O   . GLY A 1 274 ? -4.687  -28.681 -15.830 0.41 34.68  ? 537  GLY A O   1 
ATOM   1843 N  N   . TRP A 1 275 ? -5.464  -30.430 -17.075 0.41 34.16  ? 538  TRP A N   1 
ATOM   1844 C  CA  . TRP A 1 275 ? -5.958  -29.632 -18.231 0.41 34.61  ? 538  TRP A CA  1 
ATOM   1845 C  C   . TRP A 1 275 ? -6.821  -28.452 -17.756 0.41 34.26  ? 538  TRP A C   1 
ATOM   1846 O  O   . TRP A 1 275 ? -6.541  -27.315 -18.177 0.41 34.93  ? 538  TRP A O   1 
ATOM   1847 C  CB  . TRP A 1 275 ? -6.734  -30.512 -19.215 0.41 33.13  ? 538  TRP A CB  1 
ATOM   1848 C  CG  . TRP A 1 275 ? -7.340  -29.721 -20.331 0.41 32.87  ? 538  TRP A CG  1 
ATOM   1849 C  CD1 . TRP A 1 275 ? -8.552  -29.097 -20.328 0.41 33.26  ? 538  TRP A CD1 1 
ATOM   1850 C  CD2 . TRP A 1 275 ? -6.755  -29.450 -21.615 0.41 32.42  ? 538  TRP A CD2 1 
ATOM   1851 N  NE1 . TRP A 1 275 ? -8.762  -28.468 -21.524 0.41 34.01  ? 538  TRP A NE1 1 
ATOM   1852 C  CE2 . TRP A 1 275 ? -7.680  -28.664 -22.333 0.41 33.17  ? 538  TRP A CE2 1 
ATOM   1853 C  CE3 . TRP A 1 275 ? -5.551  -29.799 -22.231 0.41 32.79  ? 538  TRP A CE3 1 
ATOM   1854 C  CZ2 . TRP A 1 275 ? -7.434  -28.217 -23.629 0.41 33.43  ? 538  TRP A CZ2 1 
ATOM   1855 C  CZ3 . TRP A 1 275 ? -5.308  -29.358 -23.512 0.41 33.47  ? 538  TRP A CZ3 1 
ATOM   1856 C  CH2 . TRP A 1 275 ? -6.238  -28.581 -24.199 0.41 35.16  ? 538  TRP A CH2 1 
ATOM   1857 N  N   . ASP A 1 276 ? -7.838  -28.718 -16.938 0.41 35.63  ? 539  ASP A N   1 
ATOM   1858 C  CA  . ASP A 1 276 ? -8.834  -27.706 -16.476 0.41 37.88  ? 539  ASP A CA  1 
ATOM   1859 C  C   . ASP A 1 276 ? -8.110  -26.546 -15.767 0.41 39.78  ? 539  ASP A C   1 
ATOM   1860 O  O   . ASP A 1 276 ? -8.500  -25.375 -15.995 0.41 38.34  ? 539  ASP A O   1 
ATOM   1861 C  CB  . ASP A 1 276 ? -9.912  -28.344 -15.596 0.41 37.66  ? 539  ASP A CB  1 
ATOM   1862 C  CG  . ASP A 1 276 ? -11.090 -28.934 -16.366 0.41 40.24  ? 539  ASP A CG  1 
ATOM   1863 O  OD1 . ASP A 1 276 ? -10.906 -29.336 -17.540 0.41 40.62  ? 539  ASP A OD1 1 
ATOM   1864 O  OD2 . ASP A 1 276 ? -12.193 -28.991 -15.789 0.41 42.33  ? 539  ASP A OD2 1 
ATOM   1865 N  N   . THR A 1 277 ? -7.071  -26.847 -14.981 1.00 39.24  ? 540  THR A N   1 
ATOM   1866 C  CA  . THR A 1 277 ? -6.292  -25.812 -14.237 1.00 41.11  ? 540  THR A CA  1 
ATOM   1867 C  C   . THR A 1 277 ? -5.385  -24.982 -15.141 1.00 40.88  ? 540  THR A C   1 
ATOM   1868 O  O   . THR A 1 277 ? -4.949  -23.965 -14.679 1.00 41.08  ? 540  THR A O   1 
ATOM   1869 C  CB  . THR A 1 277 ? -5.453  -26.387 -13.085 1.00 42.43  ? 540  THR A CB  1 
ATOM   1870 O  OG1 . THR A 1 277 ? -4.427  -27.250 -13.571 1.00 48.86  ? 540  THR A OG1 1 
ATOM   1871 C  CG2 . THR A 1 277 ? -6.301  -27.164 -12.114 1.00 42.99  ? 540  THR A CG2 1 
ATOM   1872 N  N   . ARG A 1 278 ? -5.138  -25.424 -16.383 0.41 39.40  ? 541  ARG A N   1 
ATOM   1873 C  CA  . ARG A 1 278 ? -4.206  -24.782 -17.352 0.41 39.07  ? 541  ARG A CA  1 
ATOM   1874 C  C   . ARG A 1 278 ? -4.971  -23.987 -18.415 0.41 38.04  ? 541  ARG A C   1 
ATOM   1875 O  O   . ARG A 1 278 ? -4.313  -23.532 -19.372 0.41 37.13  ? 541  ARG A O   1 
ATOM   1876 C  CB  . ARG A 1 278 ? -3.365  -25.842 -18.072 0.41 43.31  ? 541  ARG A CB  1 
ATOM   1877 C  CG  . ARG A 1 278 ? -2.706  -26.855 -17.151 0.41 46.16  ? 541  ARG A CG  1 
ATOM   1878 C  CD  . ARG A 1 278 ? -1.491  -26.283 -16.459 0.41 52.27  ? 541  ARG A CD  1 
ATOM   1879 N  NE  . ARG A 1 278 ? -0.806  -27.311 -15.681 0.41 62.81  ? 541  ARG A NE  1 
ATOM   1880 C  CZ  . ARG A 1 278 ? 0.490   -27.308 -15.376 0.41 65.76  ? 541  ARG A CZ  1 
ATOM   1881 N  NH1 . ARG A 1 278 ? 1.280   -26.336 -15.806 0.41 67.74  ? 541  ARG A NH1 1 
ATOM   1882 N  NH2 . ARG A 1 278 ? 0.993   -28.288 -14.644 0.41 68.42  ? 541  ARG A NH2 1 
ATOM   1883 N  N   . ILE A 1 279 ? -6.301  -23.882 -18.296 1.00 35.46  ? 542  ILE A N   1 
ATOM   1884 C  CA  . ILE A 1 279 ? -7.121  -23.059 -19.220 1.00 35.72  ? 542  ILE A CA  1 
ATOM   1885 C  C   . ILE A 1 279 ? -6.844  -21.598 -18.848 1.00 35.23  ? 542  ILE A C   1 
ATOM   1886 O  O   . ILE A 1 279 ? -7.122  -21.193 -17.760 1.00 38.23  ? 542  ILE A O   1 
ATOM   1887 C  CB  . ILE A 1 279 ? -8.603  -23.455 -19.166 1.00 37.67  ? 542  ILE A CB  1 
ATOM   1888 C  CG1 . ILE A 1 279 ? -8.822  -24.821 -19.817 1.00 35.10  ? 542  ILE A CG1 1 
ATOM   1889 C  CG2 . ILE A 1 279 ? -9.497  -22.398 -19.826 1.00 37.08  ? 542  ILE A CG2 1 
ATOM   1890 C  CD1 . ILE A 1 279 ? -8.648  -24.790 -21.309 1.00 36.09  ? 542  ILE A CD1 1 
ATOM   1891 N  N   . THR A 1 280 ? -6.253  -20.855 -19.785 0.41 38.57  ? 543  THR A N   1 
ATOM   1892 C  CA  . THR A 1 280 ? -5.806  -19.447 -19.618 0.41 39.77  ? 543  THR A CA  1 
ATOM   1893 C  C   . THR A 1 280 ? -6.988  -18.512 -19.888 0.41 41.54  ? 543  THR A C   1 
ATOM   1894 O  O   . THR A 1 280 ? -8.014  -18.993 -20.429 0.41 39.52  ? 543  THR A O   1 
ATOM   1895 C  CB  . THR A 1 280 ? -4.638  -19.133 -20.559 0.41 37.99  ? 543  THR A CB  1 
ATOM   1896 O  OG1 . THR A 1 280 ? -5.115  -19.162 -21.904 0.41 38.78  ? 543  THR A OG1 1 
ATOM   1897 C  CG2 . THR A 1 280 ? -3.493  -20.109 -20.418 0.41 40.65  ? 543  THR A CG2 1 
ATOM   1898 N  N   . LEU A 1 281 ? -6.844  -17.225 -19.562 1.00 42.66  ? 544  LEU A N   1 
ATOM   1899 C  CA  . LEU A 1 281 ? -7.882  -16.224 -19.906 1.00 44.48  ? 544  LEU A CA  1 
ATOM   1900 C  C   . LEU A 1 281 ? -7.861  -16.066 -21.435 1.00 39.09  ? 544  LEU A C   1 
ATOM   1901 O  O   . LEU A 1 281 ? -8.885  -15.805 -22.027 1.00 37.15  ? 544  LEU A O   1 
ATOM   1902 C  CB  . LEU A 1 281 ? -7.606  -14.914 -19.154 1.00 59.57  ? 544  LEU A CB  1 
ATOM   1903 C  CG  . LEU A 1 281 ? -8.579  -13.766 -19.454 1.00 65.72  ? 544  LEU A CG  1 
ATOM   1904 C  CD1 . LEU A 1 281 ? -10.052 -14.198 -19.352 1.00 56.97  ? 544  LEU A CD1 1 
ATOM   1905 C  CD2 . LEU A 1 281 ? -8.301  -12.576 -18.531 1.00 64.55  ? 544  LEU A CD2 1 
ATOM   1906 N  N   . GLU A 1 282 ? -6.726  -16.287 -22.084 1.00 37.42  ? 545  GLU A N   1 
ATOM   1907 C  CA  . GLU A 1 282 ? -6.663  -16.198 -23.572 1.00 38.73  ? 545  GLU A CA  1 
ATOM   1908 C  C   . GLU A 1 282 ? -7.489  -17.329 -24.209 1.00 40.33  ? 545  GLU A C   1 
ATOM   1909 O  O   . GLU A 1 282 ? -8.193  -17.091 -25.261 1.00 41.56  ? 545  GLU A O   1 
ATOM   1910 C  CB  . GLU A 1 282 ? -5.206  -16.183 -23.995 1.00 46.30  ? 545  GLU A CB  1 
ATOM   1911 C  CG  . GLU A 1 282 ? -5.008  -15.516 -25.334 1.00 60.59  ? 545  GLU A CG  1 
ATOM   1912 C  CD  . GLU A 1 282 ? -5.160  -13.994 -25.392 1.00 59.12  ? 545  GLU A CD  1 
ATOM   1913 O  OE1 . GLU A 1 282 ? -5.088  -13.326 -24.329 1.00 55.10  ? 545  GLU A OE1 1 
ATOM   1914 O  OE2 . GLU A 1 282 ? -5.369  -13.492 -26.529 1.00 65.08  ? 545  GLU A OE2 1 
ATOM   1915 N  N   . ASP A 1 283 ? -7.437  -18.520 -23.600 0.41 37.91  ? 546  ASP A N   1 
ATOM   1916 C  CA  . ASP A 1 283 ? -8.254  -19.703 -23.989 0.41 36.96  ? 546  ASP A CA  1 
ATOM   1917 C  C   . ASP A 1 283 ? -9.746  -19.337 -23.898 0.41 38.51  ? 546  ASP A C   1 
ATOM   1918 O  O   . ASP A 1 283 ? -10.463 -19.539 -24.901 0.41 37.96  ? 546  ASP A O   1 
ATOM   1919 C  CB  . ASP A 1 283 ? -7.915  -20.928 -23.131 0.41 35.57  ? 546  ASP A CB  1 
ATOM   1920 C  CG  . ASP A 1 283 ? -6.554  -21.568 -23.396 0.41 35.05  ? 546  ASP A CG  1 
ATOM   1921 O  OD1 . ASP A 1 283 ? -6.043  -21.438 -24.529 0.41 33.78  ? 546  ASP A OD1 1 
ATOM   1922 O  OD2 . ASP A 1 283 ? -6.023  -22.220 -22.464 0.41 34.42  ? 546  ASP A OD2 1 
ATOM   1923 N  N   . LEU A 1 284 ? -10.187 -18.799 -22.756 0.41 38.32  ? 547  LEU A N   1 
ATOM   1924 C  CA  . LEU A 1 284 ? -11.603 -18.407 -22.500 0.41 38.73  ? 547  LEU A CA  1 
ATOM   1925 C  C   . LEU A 1 284 ? -12.055 -17.349 -23.523 0.41 37.90  ? 547  LEU A C   1 
ATOM   1926 O  O   . LEU A 1 284 ? -13.193 -17.456 -24.012 0.41 38.04  ? 547  LEU A O   1 
ATOM   1927 C  CB  . LEU A 1 284 ? -11.729 -17.905 -21.058 0.41 40.53  ? 547  LEU A CB  1 
ATOM   1928 C  CG  . LEU A 1 284 ? -11.458 -18.948 -19.972 0.41 40.26  ? 547  LEU A CG  1 
ATOM   1929 C  CD1 . LEU A 1 284 ? -11.410 -18.298 -18.600 0.41 44.99  ? 547  LEU A CD1 1 
ATOM   1930 C  CD2 . LEU A 1 284 ? -12.500 -20.059 -19.988 0.41 40.68  ? 547  LEU A CD2 1 
ATOM   1931 N  N   . LYS A 1 285 ? -11.182 -16.403 -23.884 1.00 37.71  ? 548  LYS A N   1 
ATOM   1932 C  CA  . LYS A 1 285 ? -11.483 -15.374 -24.922 1.00 40.36  ? 548  LYS A CA  1 
ATOM   1933 C  C   . LYS A 1 285 ? -11.601 -15.993 -26.320 1.00 40.80  ? 548  LYS A C   1 
ATOM   1934 O  O   . LYS A 1 285 ? -12.464 -15.558 -27.067 1.00 39.62  ? 548  LYS A O   1 
ATOM   1935 C  CB  . LYS A 1 285 ? -10.462 -14.221 -24.896 1.00 42.20  ? 548  LYS A CB  1 
ATOM   1936 C  CG  . LYS A 1 285 ? -10.562 -13.392 -23.627 1.00 48.93  ? 548  LYS A CG  1 
ATOM   1937 C  CD  . LYS A 1 285 ? -9.766  -12.092 -23.592 1.00 70.41  ? 548  LYS A CD  1 
ATOM   1938 C  CE  . LYS A 1 285 ? -10.307 -11.119 -22.548 1.00 76.13  ? 548  LYS A CE  1 
ATOM   1939 N  NZ  . LYS A 1 285 ? -9.259  -10.193 -22.044 1.00 95.27  ? 548  LYS A NZ  1 
ATOM   1940 N  N   . ASN A 1 286 ? -10.804 -16.991 -26.675 1.00 31.21  ? 549  ASN A N   1 
ATOM   1941 C  CA  . ASN A 1 286 ? -10.947 -17.654 -27.983 1.00 32.25  ? 549  ASN A CA  1 
ATOM   1942 C  C   . ASN A 1 286 ? -12.219 -18.512 -28.021 1.00 29.56  ? 549  ASN A C   1 
ATOM   1943 O  O   . ASN A 1 286 ? -12.886 -18.570 -29.095 1.00 32.49  ? 549  ASN A O   1 
ATOM   1944 C  CB  . ASN A 1 286 ? -9.676  -18.439 -28.267 1.00 36.87  ? 549  ASN A CB  1 
ATOM   1945 C  CG  . ASN A 1 286 ? -8.518  -17.478 -28.447 1.00 44.38  ? 549  ASN A CG  1 
ATOM   1946 O  OD1 . ASN A 1 286 ? -8.707  -16.416 -29.025 1.00 41.87  ? 549  ASN A OD1 1 
ATOM   1947 N  ND2 . ASN A 1 286 ? -7.327  -17.864 -28.036 1.00 43.23  ? 549  ASN A ND2 1 
ATOM   1948 N  N   . GLU A 1 287 ? -12.568 -19.119 -26.907 1.00 28.66  ? 550  GLU A N   1 
ATOM   1949 C  CA  . GLU A 1 287 ? -13.821 -19.925 -26.784 1.00 33.25  ? 550  GLU A CA  1 
ATOM   1950 C  C   . GLU A 1 287 ? -15.048 -18.991 -26.965 1.00 35.42  ? 550  GLU A C   1 
ATOM   1951 O  O   . GLU A 1 287 ? -16.019 -19.383 -27.681 1.00 31.47  ? 550  GLU A O   1 
ATOM   1952 C  CB  . GLU A 1 287 ? -13.779 -20.636 -25.438 1.00 31.00  ? 550  GLU A CB  1 
ATOM   1953 C  CG  . GLU A 1 287 ? -12.795 -21.800 -25.442 1.00 32.87  ? 550  GLU A CG  1 
ATOM   1954 C  CD  . GLU A 1 287 ? -12.501 -22.398 -24.082 1.00 35.17  ? 550  GLU A CD  1 
ATOM   1955 O  OE1 . GLU A 1 287 ? -13.149 -21.969 -23.087 1.00 40.42  ? 550  GLU A OE1 1 
ATOM   1956 O  OE2 . GLU A 1 287 ? -11.616 -23.316 -23.990 1.00 43.46  ? 550  GLU A OE2 1 
ATOM   1957 N  N   . GLU A 1 288 ? -14.978 -17.786 -26.388 0.41 35.19  ? 551  GLU A N   1 
ATOM   1958 C  CA  . GLU A 1 288 ? -16.065 -16.766 -26.415 0.41 37.09  ? 551  GLU A CA  1 
ATOM   1959 C  C   . GLU A 1 288 ? -16.408 -16.373 -27.859 0.41 36.59  ? 551  GLU A C   1 
ATOM   1960 O  O   . GLU A 1 288 ? -17.565 -15.973 -28.086 0.41 39.45  ? 551  GLU A O   1 
ATOM   1961 C  CB  . GLU A 1 288 ? -15.668 -15.537 -25.593 0.41 39.95  ? 551  GLU A CB  1 
ATOM   1962 C  CG  . GLU A 1 288 ? -16.821 -14.577 -25.323 0.41 41.66  ? 551  GLU A CG  1 
ATOM   1963 C  CD  . GLU A 1 288 ? -17.135 -13.574 -26.426 0.41 43.87  ? 551  GLU A CD  1 
ATOM   1964 O  OE1 . GLU A 1 288 ? -16.186 -13.132 -27.108 0.41 45.28  ? 551  GLU A OE1 1 
ATOM   1965 O  OE2 . GLU A 1 288 ? -18.337 -13.225 -26.597 0.41 44.42  ? 551  GLU A OE2 1 
ATOM   1966 N  N   . MET A 1 289 ? -15.470 -16.502 -28.803 1.00 33.58  ? 552  MET A N   1 
ATOM   1967 C  CA  . MET A 1 289 ? -15.704 -16.097 -30.209 1.00 35.33  ? 552  MET A CA  1 
ATOM   1968 C  C   . MET A 1 289 ? -16.829 -16.912 -30.859 1.00 36.95  ? 552  MET A C   1 
ATOM   1969 O  O   . MET A 1 289 ? -17.253 -16.568 -32.027 1.00 36.94  ? 552  MET A O   1 
ATOM   1970 C  CB  . MET A 1 289 ? -14.429 -16.181 -31.061 1.00 37.25  ? 552  MET A CB  1 
ATOM   1971 C  CG  . MET A 1 289 ? -13.320 -15.265 -30.540 1.00 46.22  ? 552  MET A CG  1 
ATOM   1972 S  SD  . MET A 1 289 ? -12.085 -14.783 -31.833 1.00 54.20  ? 552  MET A SD  1 
ATOM   1973 C  CE  . MET A 1 289 ? -11.419 -16.361 -32.330 1.00 46.74  ? 552  MET A CE  1 
ATOM   1974 N  N   . VAL A 1 290 ? -17.321 -17.980 -30.221 1.00 35.33  ? 553  VAL A N   1 
ATOM   1975 C  CA  . VAL A 1 290 ? -18.490 -18.706 -30.779 1.00 33.84  ? 553  VAL A CA  1 
ATOM   1976 C  C   . VAL A 1 290 ? -19.674 -17.712 -30.843 1.00 29.54  ? 553  VAL A C   1 
ATOM   1977 O  O   . VAL A 1 290 ? -20.498 -17.871 -31.747 1.00 38.28  ? 553  VAL A O   1 
ATOM   1978 C  CB  . VAL A 1 290 ? -18.832 -19.979 -29.980 1.00 30.61  ? 553  VAL A CB  1 
ATOM   1979 C  CG1 . VAL A 1 290 ? -19.315 -19.707 -28.572 1.00 31.61  ? 553  VAL A CG1 1 
ATOM   1980 C  CG2 . VAL A 1 290 ? -19.857 -20.785 -30.733 1.00 32.74  ? 553  VAL A CG2 1 
ATOM   1981 N  N   . THR A 1 291 ? -19.727 -16.721 -29.946 1.00 28.82  ? 554  THR A N   1 
ATOM   1982 C  CA  . THR A 1 291 ? -20.797 -15.666 -29.938 1.00 33.83  ? 554  THR A CA  1 
ATOM   1983 C  C   . THR A 1 291 ? -20.773 -14.817 -31.208 1.00 36.70  ? 554  THR A C   1 
ATOM   1984 O  O   . THR A 1 291 ? -21.842 -14.263 -31.563 1.00 40.00  ? 554  THR A O   1 
ATOM   1985 C  CB  . THR A 1 291 ? -20.683 -14.692 -28.781 1.00 33.58  ? 554  THR A CB  1 
ATOM   1986 O  OG1 . THR A 1 291 ? -19.400 -14.085 -28.830 1.00 35.03  ? 554  THR A OG1 1 
ATOM   1987 C  CG2 . THR A 1 291 ? -20.859 -15.360 -27.453 1.00 32.97  ? 554  THR A CG2 1 
ATOM   1988 N  N   . ASN A 1 292 ? -19.649 -14.755 -31.908 1.00 37.40  ? 555  ASN A N   1 
ATOM   1989 C  CA  . ASN A 1 292 ? -19.564 -14.028 -33.211 1.00 43.03  ? 555  ASN A CA  1 
ATOM   1990 C  C   . ASN A 1 292 ? -20.495 -14.626 -34.267 1.00 46.51  ? 555  ASN A C   1 
ATOM   1991 O  O   . ASN A 1 292 ? -20.768 -13.956 -35.288 1.00 48.32  ? 555  ASN A O   1 
ATOM   1992 C  CB  . ASN A 1 292 ? -18.168 -14.018 -33.844 1.00 39.25  ? 555  ASN A CB  1 
ATOM   1993 C  CG  . ASN A 1 292 ? -17.175 -13.279 -32.986 1.00 41.22  ? 555  ASN A CG  1 
ATOM   1994 O  OD1 . ASN A 1 292 ? -17.553 -12.634 -31.999 1.00 48.95  ? 555  ASN A OD1 1 
ATOM   1995 N  ND2 . ASN A 1 292 ? -15.902 -13.476 -33.276 1.00 45.71  ? 555  ASN A ND2 1 
ATOM   1996 N  N   . HIS A 1 293 ? -20.957 -15.858 -34.052 0.41 42.74  ? 556  HIS A N   1 
ATOM   1997 C  CA  . HIS A 1 293 ? -21.791 -16.617 -35.020 0.41 43.66  ? 556  HIS A CA  1 
ATOM   1998 C  C   . HIS A 1 293 ? -23.254 -16.613 -34.557 0.41 40.35  ? 556  HIS A C   1 
ATOM   1999 O  O   . HIS A 1 293 ? -24.066 -17.308 -35.187 0.41 41.35  ? 556  HIS A O   1 
ATOM   2000 C  CB  . HIS A 1 293 ? -21.172 -18.008 -35.216 0.41 42.39  ? 556  HIS A CB  1 
ATOM   2001 C  CG  . HIS A 1 293 ? -19.710 -17.934 -35.513 0.41 42.52  ? 556  HIS A CG  1 
ATOM   2002 N  ND1 . HIS A 1 293 ? -19.223 -17.787 -36.800 0.41 41.79  ? 556  HIS A ND1 1 
ATOM   2003 C  CD2 . HIS A 1 293 ? -18.632 -17.927 -34.697 0.41 41.35  ? 556  HIS A CD2 1 
ATOM   2004 C  CE1 . HIS A 1 293 ? -17.907 -17.723 -36.764 0.41 39.87  ? 556  HIS A CE1 1 
ATOM   2005 N  NE2 . HIS A 1 293 ? -17.520 -17.802 -35.484 0.41 40.30  ? 556  HIS A NE2 1 
ATOM   2006 N  N   . MET A 1 294 ? -23.565 -15.844 -33.507 1.00 39.06  ? 557  MET A N   1 
ATOM   2007 C  CA  . MET A 1 294 ? -24.911 -15.775 -32.899 1.00 39.95  ? 557  MET A CA  1 
ATOM   2008 C  C   . MET A 1 294 ? -25.582 -14.440 -33.288 1.00 44.17  ? 557  MET A C   1 
ATOM   2009 O  O   . MET A 1 294 ? -24.961 -13.623 -33.920 1.00 43.44  ? 557  MET A O   1 
ATOM   2010 C  CB  . MET A 1 294 ? -24.780 -15.879 -31.385 1.00 36.59  ? 557  MET A CB  1 
ATOM   2011 C  CG  . MET A 1 294 ? -24.218 -17.239 -30.916 1.00 37.16  ? 557  MET A CG  1 
ATOM   2012 S  SD  . MET A 1 294 ? -24.227 -17.283 -29.142 1.00 35.78  ? 557  MET A SD  1 
ATOM   2013 C  CE  . MET A 1 294 ? -23.359 -18.823 -28.799 1.00 43.09  ? 557  MET A CE  1 
ATOM   2014 N  N   . GLU A 1 295 ? -26.846 -14.271 -32.876 0.41 46.51  ? 558  GLU A N   1 
ATOM   2015 C  CA  . GLU A 1 295 ? -27.662 -13.035 -33.054 0.41 47.86  ? 558  GLU A CA  1 
ATOM   2016 C  C   . GLU A 1 295 ? -28.720 -12.944 -31.945 0.41 47.93  ? 558  GLU A C   1 
ATOM   2017 O  O   . GLU A 1 295 ? -29.019 -13.982 -31.319 0.41 48.34  ? 558  GLU A O   1 
ATOM   2018 C  CB  . GLU A 1 295 ? -28.328 -13.029 -34.432 0.41 47.32  ? 558  GLU A CB  1 
ATOM   2019 C  CG  . GLU A 1 295 ? -29.546 -13.932 -34.541 0.41 48.55  ? 558  GLU A CG  1 
ATOM   2020 C  CD  . GLU A 1 295 ? -30.328 -13.813 -35.841 0.41 53.03  ? 558  GLU A CD  1 
ATOM   2021 O  OE1 . GLU A 1 295 ? -29.699 -13.576 -36.899 0.41 59.45  ? 558  GLU A OE1 1 
ATOM   2022 O  OE2 . GLU A 1 295 ? -31.563 -13.967 -35.800 0.41 52.74  ? 558  GLU A OE2 1 
ATOM   2023 N  N   . GLY A 1 296 ? -29.273 -11.743 -31.734 0.41 51.24  ? 559  GLY A N   1 
ATOM   2024 C  CA  . GLY A 1 296 ? -30.476 -11.494 -30.914 0.41 46.27  ? 559  GLY A CA  1 
ATOM   2025 C  C   . GLY A 1 296 ? -30.253 -11.786 -29.439 0.41 47.75  ? 559  GLY A C   1 
ATOM   2026 O  O   . GLY A 1 296 ? -29.107 -11.613 -28.964 0.41 46.72  ? 559  GLY A O   1 
ATOM   2027 N  N   . GLU A 1 297 ? -31.317 -12.220 -28.749 0.41 46.37  ? 560  GLU A N   1 
ATOM   2028 C  CA  . GLU A 1 297 ? -31.322 -12.609 -27.311 0.41 48.27  ? 560  GLU A CA  1 
ATOM   2029 C  C   . GLU A 1 297 ? -30.241 -13.673 -27.044 0.41 46.73  ? 560  GLU A C   1 
ATOM   2030 O  O   . GLU A 1 297 ? -29.671 -13.685 -25.943 0.41 40.46  ? 560  GLU A O   1 
ATOM   2031 C  CB  . GLU A 1 297 ? -32.701 -13.145 -26.916 0.41 51.64  ? 560  GLU A CB  1 
ATOM   2032 C  CG  . GLU A 1 297 ? -32.948 -13.146 -25.418 0.41 55.95  ? 560  GLU A CG  1 
ATOM   2033 C  CD  . GLU A 1 297 ? -34.255 -13.784 -24.967 0.41 60.09  ? 560  GLU A CD  1 
ATOM   2034 O  OE1 . GLU A 1 297 ? -34.631 -14.835 -25.527 0.41 58.01  ? 560  GLU A OE1 1 
ATOM   2035 O  OE2 . GLU A 1 297 ? -34.891 -13.239 -24.036 0.41 66.55  ? 560  GLU A OE2 1 
ATOM   2036 N  N   . HIS A 1 298 ? -29.966 -14.541 -28.017 0.41 47.10  ? 561  HIS A N   1 
ATOM   2037 C  CA  . HIS A 1 298 ? -28.955 -15.624 -27.894 0.41 48.48  ? 561  HIS A CA  1 
ATOM   2038 C  C   . HIS A 1 298 ? -27.556 -15.010 -27.740 0.41 47.26  ? 561  HIS A C   1 
ATOM   2039 O  O   . HIS A 1 298 ? -26.891 -15.309 -26.728 0.41 52.48  ? 561  HIS A O   1 
ATOM   2040 C  CB  . HIS A 1 298 ? -29.060 -16.594 -29.075 0.41 47.61  ? 561  HIS A CB  1 
ATOM   2041 C  CG  . HIS A 1 298 ? -28.240 -17.828 -28.900 0.41 48.13  ? 561  HIS A CG  1 
ATOM   2042 N  ND1 . HIS A 1 298 ? -27.834 -18.601 -29.970 0.41 47.15  ? 561  HIS A ND1 1 
ATOM   2043 C  CD2 . HIS A 1 298 ? -27.735 -18.410 -27.790 0.41 46.30  ? 561  HIS A CD2 1 
ATOM   2044 C  CE1 . HIS A 1 298 ? -27.131 -19.621 -29.523 0.41 47.68  ? 561  HIS A CE1 1 
ATOM   2045 N  NE2 . HIS A 1 298 ? -27.061 -19.529 -28.191 0.41 47.51  ? 561  HIS A NE2 1 
ATOM   2046 N  N   . LYS A 1 299 ? -27.145 -14.153 -28.679 0.41 47.03  ? 562  LYS A N   1 
ATOM   2047 C  CA  . LYS A 1 299 ? -25.782 -13.557 -28.727 0.41 48.81  ? 562  LYS A CA  1 
ATOM   2048 C  C   . LYS A 1 299 ? -25.474 -12.852 -27.402 0.41 53.06  ? 562  LYS A C   1 
ATOM   2049 O  O   . LYS A 1 299 ? -24.346 -13.027 -26.889 0.41 54.35  ? 562  LYS A O   1 
ATOM   2050 C  CB  . LYS A 1 299 ? -25.640 -12.573 -29.892 0.41 47.44  ? 562  LYS A CB  1 
ATOM   2051 C  CG  . LYS A 1 299 ? -24.221 -12.069 -30.125 0.41 46.00  ? 562  LYS A CG  1 
ATOM   2052 C  CD  . LYS A 1 299 ? -24.105 -11.023 -31.213 0.41 46.23  ? 562  LYS A CD  1 
ATOM   2053 C  CE  . LYS A 1 299 ? -22.677 -10.654 -31.561 0.41 45.99  ? 562  LYS A CE  1 
ATOM   2054 N  NZ  . LYS A 1 299 ? -22.114 -11.518 -32.628 0.41 44.74  ? 562  LYS A NZ  1 
ATOM   2055 N  N   . LYS A 1 300 ? -26.425 -12.079 -26.872 0.41 53.21  ? 563  LYS A N   1 
ATOM   2056 C  CA  . LYS A 1 300 ? -26.220 -11.271 -25.639 0.41 55.18  ? 563  LYS A CA  1 
ATOM   2057 C  C   . LYS A 1 300 ? -26.170 -12.213 -24.434 0.41 49.81  ? 563  LYS A C   1 
ATOM   2058 O  O   . LYS A 1 300 ? -25.251 -12.054 -23.610 0.41 51.84  ? 563  LYS A O   1 
ATOM   2059 C  CB  . LYS A 1 300 ? -27.314 -10.208 -25.475 0.41 60.93  ? 563  LYS A CB  1 
ATOM   2060 C  CG  . LYS A 1 300 ? -27.437 -9.209  -26.624 0.41 64.91  ? 563  LYS A CG  1 
ATOM   2061 C  CD  . LYS A 1 300 ? -26.166 -8.435  -26.941 0.41 66.09  ? 563  LYS A CD  1 
ATOM   2062 C  CE  . LYS A 1 300 ? -26.362 -7.394  -28.026 0.41 70.17  ? 563  LYS A CE  1 
ATOM   2063 N  NZ  . LYS A 1 300 ? -25.136 -6.589  -28.255 0.41 70.52  ? 563  LYS A NZ  1 
ATOM   2064 N  N   . LEU A 1 301 ? -27.112 -13.156 -24.350 0.41 47.97  ? 564  LEU A N   1 
ATOM   2065 C  CA  . LEU A 1 301 ? -27.187 -14.159 -23.254 0.41 47.79  ? 564  LEU A CA  1 
ATOM   2066 C  C   . LEU A 1 301 ? -25.877 -14.969 -23.214 0.41 48.89  ? 564  LEU A C   1 
ATOM   2067 O  O   . LEU A 1 301 ? -25.273 -15.051 -22.123 0.41 45.74  ? 564  LEU A O   1 
ATOM   2068 C  CB  . LEU A 1 301 ? -28.413 -15.060 -23.459 0.41 49.38  ? 564  LEU A CB  1 
ATOM   2069 C  CG  . LEU A 1 301 ? -29.779 -14.456 -23.101 0.41 49.73  ? 564  LEU A CG  1 
ATOM   2070 C  CD1 . LEU A 1 301 ? -30.892 -15.465 -23.348 0.41 47.35  ? 564  LEU A CD1 1 
ATOM   2071 C  CD2 . LEU A 1 301 ? -29.823 -13.972 -21.657 0.41 48.46  ? 564  LEU A CD2 1 
ATOM   2072 N  N   . ALA A 1 302 ? -25.424 -15.498 -24.359 1.00 45.22  ? 565  ALA A N   1 
ATOM   2073 C  CA  . ALA A 1 302 ? -24.162 -16.287 -24.444 1.00 46.00  ? 565  ALA A CA  1 
ATOM   2074 C  C   . ALA A 1 302 ? -23.000 -15.399 -23.994 1.00 46.10  ? 565  ALA A C   1 
ATOM   2075 O  O   . ALA A 1 302 ? -22.170 -15.863 -23.215 1.00 47.09  ? 565  ALA A O   1 
ATOM   2076 C  CB  . ALA A 1 302 ? -23.921 -16.815 -25.839 1.00 41.25  ? 565  ALA A CB  1 
ATOM   2077 N  N   . GLU A 1 303 ? -22.966 -14.152 -24.457 1.00 47.32  ? 566  GLU A N   1 
ATOM   2078 C  CA  . GLU A 1 303 ? -21.923 -13.171 -24.057 1.00 44.83  ? 566  GLU A CA  1 
ATOM   2079 C  C   . GLU A 1 303 ? -21.912 -13.014 -22.534 1.00 43.76  ? 566  GLU A C   1 
ATOM   2080 O  O   . GLU A 1 303 ? -20.837 -12.913 -21.967 1.00 43.30  ? 566  GLU A O   1 
ATOM   2081 C  CB  . GLU A 1 303 ? -22.130 -11.842 -24.762 1.00 51.48  ? 566  GLU A CB  1 
ATOM   2082 C  CG  . GLU A 1 303 ? -21.570 -11.850 -26.152 1.00 53.19  ? 566  GLU A CG  1 
ATOM   2083 C  CD  . GLU A 1 303 ? -22.009 -10.656 -26.967 1.00 58.72  ? 566  GLU A CD  1 
ATOM   2084 O  OE1 . GLU A 1 303 ? -22.546 -9.734  -26.357 1.00 68.61  ? 566  GLU A OE1 1 
ATOM   2085 O  OE2 . GLU A 1 303 ? -21.775 -10.652 -28.212 1.00 60.61  ? 566  GLU A OE2 1 
ATOM   2086 N  N   . ALA A 1 304 ? -23.059 -13.094 -21.887 1.00 41.44  ? 567  ALA A N   1 
ATOM   2087 C  CA  . ALA A 1 304 ? -23.144 -12.888 -20.428 1.00 49.38  ? 567  ALA A CA  1 
ATOM   2088 C  C   . ALA A 1 304 ? -22.625 -14.132 -19.698 1.00 44.12  ? 567  ALA A C   1 
ATOM   2089 O  O   . ALA A 1 304 ? -22.002 -13.947 -18.637 1.00 40.91  ? 567  ALA A O   1 
ATOM   2090 C  CB  . ALA A 1 304 ? -24.555 -12.525 -20.002 1.00 46.46  ? 567  ALA A CB  1 
ATOM   2091 N  N   . ILE A 1 305 ? -22.923 -15.345 -20.188 1.00 43.01  ? 568  ILE A N   1 
ATOM   2092 C  CA  . ILE A 1 305 ? -22.356 -16.591 -19.579 1.00 45.56  ? 568  ILE A CA  1 
ATOM   2093 C  C   . ILE A 1 305 ? -20.813 -16.492 -19.607 1.00 40.49  ? 568  ILE A C   1 
ATOM   2094 O  O   . ILE A 1 305 ? -20.187 -16.606 -18.547 1.00 39.55  ? 568  ILE A O   1 
ATOM   2095 C  CB  . ILE A 1 305 ? -22.872 -17.881 -20.257 1.00 47.49  ? 568  ILE A CB  1 
ATOM   2096 C  CG1 . ILE A 1 305 ? -24.387 -18.079 -20.077 1.00 47.88  ? 568  ILE A CG1 1 
ATOM   2097 C  CG2 . ILE A 1 305 ? -22.081 -19.116 -19.783 1.00 48.31  ? 568  ILE A CG2 1 
ATOM   2098 C  CD1 . ILE A 1 305 ? -24.864 -18.125 -18.645 1.00 46.85  ? 568  ILE A CD1 1 
ATOM   2099 N  N   . PHE A 1 306 ? -20.215 -16.206 -20.756 1.00 37.21  ? 569  PHE A N   1 
ATOM   2100 C  CA  . PHE A 1 306 ? -18.745 -16.120 -20.914 1.00 41.44  ? 569  PHE A CA  1 
ATOM   2101 C  C   . PHE A 1 306 ? -18.160 -15.030 -19.990 1.00 49.31  ? 569  PHE A C   1 
ATOM   2102 O  O   . PHE A 1 306 ? -17.195 -15.326 -19.252 1.00 44.66  ? 569  PHE A O   1 
ATOM   2103 C  CB  . PHE A 1 306 ? -18.350 -15.915 -22.377 1.00 40.68  ? 569  PHE A CB  1 
ATOM   2104 C  CG  . PHE A 1 306 ? -18.369 -17.163 -23.222 1.00 44.10  ? 569  PHE A CG  1 
ATOM   2105 C  CD1 . PHE A 1 306 ? -17.387 -18.131 -23.074 1.00 46.70  ? 569  PHE A CD1 1 
ATOM   2106 C  CD2 . PHE A 1 306 ? -19.319 -17.341 -24.209 1.00 43.84  ? 569  PHE A CD2 1 
ATOM   2107 C  CE1 . PHE A 1 306 ? -17.422 -19.287 -23.838 1.00 45.23  ? 569  PHE A CE1 1 
ATOM   2108 C  CE2 . PHE A 1 306 ? -19.361 -18.492 -24.980 1.00 41.18  ? 569  PHE A CE2 1 
ATOM   2109 C  CZ  . PHE A 1 306 ? -18.412 -19.467 -24.783 1.00 46.46  ? 569  PHE A CZ  1 
ATOM   2110 N  N   . LYS A 1 307 ? -18.731 -13.823 -19.988 0.41 46.15  ? 570  LYS A N   1 
ATOM   2111 C  CA  . LYS A 1 307 ? -18.122 -12.653 -19.293 0.41 47.46  ? 570  LYS A CA  1 
ATOM   2112 C  C   . LYS A 1 307 ? -18.385 -12.728 -17.783 0.41 45.56  ? 570  LYS A C   1 
ATOM   2113 O  O   . LYS A 1 307 ? -17.448 -12.424 -17.031 0.41 46.33  ? 570  LYS A O   1 
ATOM   2114 C  CB  . LYS A 1 307 ? -18.593 -11.333 -19.915 0.41 50.51  ? 570  LYS A CB  1 
ATOM   2115 C  CG  . LYS A 1 307 ? -17.804 -10.923 -21.154 0.41 51.28  ? 570  LYS A CG  1 
ATOM   2116 C  CD  . LYS A 1 307 ? -18.584 -10.105 -22.167 0.41 51.64  ? 570  LYS A CD  1 
ATOM   2117 C  CE  . LYS A 1 307 ? -18.214 -10.436 -23.598 0.41 48.32  ? 570  LYS A CE  1 
ATOM   2118 N  NZ  . LYS A 1 307 ? -18.596 -11.827 -23.940 0.41 45.66  ? 570  LYS A NZ  1 
ATOM   2119 N  N   . LEU A 1 308 ? -19.581 -13.142 -17.354 1.00 44.41  ? 571  LEU A N   1 
ATOM   2120 C  CA  . LEU A 1 308 ? -19.960 -13.071 -15.927 1.00 43.98  ? 571  LEU A CA  1 
ATOM   2121 C  C   . LEU A 1 308 ? -19.682 -14.333 -15.117 1.00 47.96  ? 571  LEU A C   1 
ATOM   2122 O  O   . LEU A 1 308 ? -19.442 -14.185 -13.868 1.00 48.47  ? 571  LEU A O   1 
ATOM   2123 C  CB  . LEU A 1 308 ? -21.441 -12.667 -15.853 1.00 48.52  ? 571  LEU A CB  1 
ATOM   2124 C  CG  . LEU A 1 308 ? -21.788 -11.386 -16.646 1.00 54.51  ? 571  LEU A CG  1 
ATOM   2125 C  CD1 . LEU A 1 308 ? -23.280 -11.114 -16.653 1.00 58.97  ? 571  LEU A CD1 1 
ATOM   2126 C  CD2 . LEU A 1 308 ? -21.063 -10.162 -16.115 1.00 50.55  ? 571  LEU A CD2 1 
ATOM   2127 N  N   . THR A 1 309 ? -19.703 -15.507 -15.758 0.41 45.24  ? 572  THR A N   1 
ATOM   2128 C  CA  . THR A 1 309 ? -19.577 -16.824 -15.080 0.41 47.18  ? 572  THR A CA  1 
ATOM   2129 C  C   . THR A 1 309 ? -18.222 -17.482 -15.394 0.41 43.42  ? 572  THR A C   1 
ATOM   2130 O  O   . THR A 1 309 ? -17.709 -18.134 -14.496 0.41 43.20  ? 572  THR A O   1 
ATOM   2131 C  CB  . THR A 1 309 ? -20.779 -17.724 -15.402 0.41 50.31  ? 572  THR A CB  1 
ATOM   2132 O  OG1 . THR A 1 309 ? -20.734 -18.099 -16.777 0.41 50.59  ? 572  THR A OG1 1 
ATOM   2133 C  CG2 . THR A 1 309 ? -22.104 -17.056 -15.107 0.41 53.10  ? 572  THR A CG2 1 
ATOM   2134 N  N   . TYR A 1 310 ? -17.656 -17.324 -16.596 0.41 43.39  ? 573  TYR A N   1 
ATOM   2135 C  CA  . TYR A 1 310 ? -16.405 -18.022 -17.018 0.41 44.42  ? 573  TYR A CA  1 
ATOM   2136 C  C   . TYR A 1 310 ? -15.191 -17.102 -16.834 0.41 44.52  ? 573  TYR A C   1 
ATOM   2137 O  O   . TYR A 1 310 ? -14.309 -17.444 -16.019 0.41 51.38  ? 573  TYR A O   1 
ATOM   2138 C  CB  . TYR A 1 310 ? -16.458 -18.507 -18.474 0.41 40.92  ? 573  TYR A CB  1 
ATOM   2139 C  CG  . TYR A 1 310 ? -17.495 -19.550 -18.820 0.41 39.01  ? 573  TYR A CG  1 
ATOM   2140 C  CD1 . TYR A 1 310 ? -18.280 -20.169 -17.862 0.41 36.99  ? 573  TYR A CD1 1 
ATOM   2141 C  CD2 . TYR A 1 310 ? -17.675 -19.931 -20.139 0.41 37.92  ? 573  TYR A CD2 1 
ATOM   2142 C  CE1 . TYR A 1 310 ? -19.236 -21.110 -18.212 0.41 36.70  ? 573  TYR A CE1 1 
ATOM   2143 C  CE2 . TYR A 1 310 ? -18.621 -20.872 -20.504 0.41 37.48  ? 573  TYR A CE2 1 
ATOM   2144 C  CZ  . TYR A 1 310 ? -19.399 -21.471 -19.537 0.41 36.14  ? 573  TYR A CZ  1 
ATOM   2145 O  OH  . TYR A 1 310 ? -20.326 -22.395 -19.918 0.41 36.18  ? 573  TYR A OH  1 
ATOM   2146 N  N   . GLN A 1 311 ? -15.147 -15.988 -17.576 0.41 40.44  ? 574  GLN A N   1 
ATOM   2147 C  CA  . GLN A 1 311 ? -14.000 -15.043 -17.636 0.41 40.67  ? 574  GLN A CA  1 
ATOM   2148 C  C   . GLN A 1 311 ? -13.863 -14.269 -16.320 0.41 41.47  ? 574  GLN A C   1 
ATOM   2149 O  O   . GLN A 1 311 ? -12.810 -13.638 -16.120 0.41 40.23  ? 574  GLN A O   1 
ATOM   2150 C  CB  . GLN A 1 311 ? -14.183 -14.064 -18.791 0.41 40.88  ? 574  GLN A CB  1 
ATOM   2151 C  CG  . GLN A 1 311 ? -14.126 -14.726 -20.155 0.41 40.77  ? 574  GLN A CG  1 
ATOM   2152 C  CD  . GLN A 1 311 ? -14.448 -13.725 -21.232 0.41 41.13  ? 574  GLN A CD  1 
ATOM   2153 O  OE1 . GLN A 1 311 ? -15.221 -12.798 -21.015 0.41 47.60  ? 574  GLN A OE1 1 
ATOM   2154 N  NE2 . GLN A 1 311 ? -13.841 -13.893 -22.395 0.41 41.18  ? 574  GLN A NE2 1 
ATOM   2155 N  N   . ASN A 1 312 ? -14.918 -14.269 -15.502 0.41 43.64  ? 575  ASN A N   1 
ATOM   2156 C  CA  . ASN A 1 312 ? -14.937 -13.819 -14.083 0.41 43.46  ? 575  ASN A CA  1 
ATOM   2157 C  C   . ASN A 1 312 ? -15.788 -14.844 -13.331 0.41 44.14  ? 575  ASN A C   1 
ATOM   2158 O  O   . ASN A 1 312 ? -16.753 -15.339 -13.946 0.41 48.13  ? 575  ASN A O   1 
ATOM   2159 C  CB  . ASN A 1 312 ? -15.486 -12.393 -13.946 0.41 42.10  ? 575  ASN A CB  1 
ATOM   2160 C  CG  . ASN A 1 312 ? -14.693 -11.364 -14.727 0.41 42.85  ? 575  ASN A CG  1 
ATOM   2161 O  OD1 . ASN A 1 312 ? -13.737 -10.791 -14.210 0.41 40.40  ? 575  ASN A OD1 1 
ATOM   2162 N  ND2 . ASN A 1 312 ? -15.084 -11.109 -15.969 0.41 42.09  ? 575  ASN A ND2 1 
ATOM   2163 N  N   . LYS A 1 313 ? -15.422 -15.206 -12.100 0.41 44.62  ? 576  LYS A N   1 
ATOM   2164 C  CA  . LYS A 1 313 ? -16.124 -16.263 -11.320 0.41 46.65  ? 576  LYS A CA  1 
ATOM   2165 C  C   . LYS A 1 313 ? -16.223 -15.852 -9.852  0.41 48.22  ? 576  LYS A C   1 
ATOM   2166 O  O   . LYS A 1 313 ? -15.526 -14.909 -9.451  0.41 54.00  ? 576  LYS A O   1 
ATOM   2167 C  CB  . LYS A 1 313 ? -15.386 -17.606 -11.357 0.41 48.10  ? 576  LYS A CB  1 
ATOM   2168 C  CG  . LYS A 1 313 ? -14.914 -18.074 -12.721 0.41 50.27  ? 576  LYS A CG  1 
ATOM   2169 C  CD  . LYS A 1 313 ? -14.227 -19.420 -12.675 0.41 50.84  ? 576  LYS A CD  1 
ATOM   2170 C  CE  . LYS A 1 313 ? -13.507 -19.749 -13.964 0.41 51.40  ? 576  LYS A CE  1 
ATOM   2171 N  NZ  . LYS A 1 313 ? -12.503 -18.716 -14.308 0.41 52.52  ? 576  LYS A NZ  1 
ATOM   2172 N  N   . VAL A 1 314 ? -17.057 -16.577 -9.106  0.41 46.33  ? 577  VAL A N   1 
ATOM   2173 C  CA  . VAL A 1 314 ? -17.183 -16.532 -7.625  0.41 47.49  ? 577  VAL A CA  1 
ATOM   2174 C  C   . VAL A 1 314 ? -17.485 -17.961 -7.180  0.41 45.46  ? 577  VAL A C   1 
ATOM   2175 O  O   . VAL A 1 314 ? -18.316 -18.603 -7.841  0.41 41.50  ? 577  VAL A O   1 
ATOM   2176 C  CB  . VAL A 1 314 ? -18.291 -15.559 -7.176  0.41 50.29  ? 577  VAL A CB  1 
ATOM   2177 C  CG1 . VAL A 1 314 ? -18.418 -15.510 -5.660  0.41 51.45  ? 577  VAL A CG1 1 
ATOM   2178 C  CG2 . VAL A 1 314 ? -18.086 -14.165 -7.750  0.41 50.07  ? 577  VAL A CG2 1 
ATOM   2179 N  N   . VAL A 1 315 ? -16.829 -18.434 -6.120  0.41 47.51  ? 578  VAL A N   1 
ATOM   2180 C  CA  . VAL A 1 315 ? -16.893 -19.856 -5.669  0.41 50.31  ? 578  VAL A CA  1 
ATOM   2181 C  C   . VAL A 1 315 ? -16.968 -19.894 -4.142  0.41 52.33  ? 578  VAL A C   1 
ATOM   2182 O  O   . VAL A 1 315 ? -16.357 -19.021 -3.496  0.41 52.88  ? 578  VAL A O   1 
ATOM   2183 C  CB  . VAL A 1 315 ? -15.681 -20.661 -6.181  0.41 51.39  ? 578  VAL A CB  1 
ATOM   2184 C  CG1 . VAL A 1 315 ? -15.791 -22.135 -5.826  0.41 52.22  ? 578  VAL A CG1 1 
ATOM   2185 C  CG2 . VAL A 1 315 ? -15.469 -20.484 -7.678  0.41 52.19  ? 578  VAL A CG2 1 
ATOM   2186 N  N   . ARG A 1 316 ? -17.661 -20.898 -3.602  0.41 56.65  ? 579  ARG A N   1 
ATOM   2187 C  CA  . ARG A 1 316 ? -17.772 -21.156 -2.144  0.41 60.62  ? 579  ARG A CA  1 
ATOM   2188 C  C   . ARG A 1 316 ? -17.182 -22.540 -1.844  0.41 61.70  ? 579  ARG A C   1 
ATOM   2189 O  O   . ARG A 1 316 ? -17.734 -23.545 -2.332  0.41 63.52  ? 579  ARG A O   1 
ATOM   2190 C  CB  . ARG A 1 316 ? -19.221 -21.008 -1.666  0.41 64.72  ? 579  ARG A CB  1 
ATOM   2191 C  CG  . ARG A 1 316 ? -20.282 -21.443 -2.665  0.41 67.41  ? 579  ARG A CG  1 
ATOM   2192 C  CD  . ARG A 1 316 ? -21.682 -21.386 -2.081  0.41 72.01  ? 579  ARG A CD  1 
ATOM   2193 N  NE  . ARG A 1 316 ? -21.983 -20.109 -1.443  0.41 72.64  ? 579  ARG A NE  1 
ATOM   2194 C  CZ  . ARG A 1 316 ? -23.096 -19.840 -0.764  0.41 72.15  ? 579  ARG A CZ  1 
ATOM   2195 N  NH1 . ARG A 1 316 ? -23.260 -18.643 -0.225  0.41 68.31  ? 579  ARG A NH1 1 
ATOM   2196 N  NH2 . ARG A 1 316 ? -24.036 -20.761 -0.625  0.41 73.35  ? 579  ARG A NH2 1 
ATOM   2197 N  N   . VAL A 1 317 ? -16.086 -22.569 -1.081  0.41 61.98  ? 580  VAL A N   1 
ATOM   2198 C  CA  . VAL A 1 317 ? -15.336 -23.799 -0.691  0.41 62.41  ? 580  VAL A CA  1 
ATOM   2199 C  C   . VAL A 1 317 ? -15.311 -23.868 0.839   0.41 64.53  ? 580  VAL A C   1 
ATOM   2200 O  O   . VAL A 1 317 ? -14.942 -22.852 1.460   0.41 60.63  ? 580  VAL A O   1 
ATOM   2201 C  CB  . VAL A 1 317 ? -13.906 -23.789 -1.265  0.41 62.06  ? 580  VAL A CB  1 
ATOM   2202 C  CG1 . VAL A 1 317 ? -13.292 -25.179 -1.254  0.41 62.38  ? 580  VAL A CG1 1 
ATOM   2203 C  CG2 . VAL A 1 317 ? -13.854 -23.193 -2.663  0.41 61.35  ? 580  VAL A CG2 1 
ATOM   2204 N  N   . GLN A 1 318 ? -15.695 -25.015 1.409   0.41 71.25  ? 581  GLN A N   1 
ATOM   2205 C  CA  . GLN A 1 318 ? -15.659 -25.279 2.873   0.41 73.99  ? 581  GLN A CA  1 
ATOM   2206 C  C   . GLN A 1 318 ? -14.212 -25.538 3.302   0.41 79.57  ? 581  GLN A C   1 
ATOM   2207 O  O   . GLN A 1 318 ? -13.490 -26.223 2.551   0.41 79.24  ? 581  GLN A O   1 
ATOM   2208 C  CB  . GLN A 1 318 ? -16.537 -26.474 3.246   0.41 71.74  ? 581  GLN A CB  1 
ATOM   2209 C  CG  . GLN A 1 318 ? -18.011 -26.123 3.384   0.41 72.61  ? 581  GLN A CG  1 
ATOM   2210 C  CD  . GLN A 1 318 ? -18.742 -27.067 4.309   0.41 72.33  ? 581  GLN A CD  1 
ATOM   2211 O  OE1 . GLN A 1 318 ? -18.396 -28.240 4.439   0.41 71.90  ? 581  GLN A OE1 1 
ATOM   2212 N  NE2 . GLN A 1 318 ? -19.766 -26.553 4.971   0.41 72.99  ? 581  GLN A NE2 1 
ATOM   2213 N  N   . ARG A 1 319 ? -13.829 -25.016 4.472   0.41 88.53  ? 582  ARG A N   1 
ATOM   2214 C  CA  . ARG A 1 319 ? -12.494 -25.192 5.106   0.41 93.95  ? 582  ARG A CA  1 
ATOM   2215 C  C   . ARG A 1 319 ? -12.712 -25.680 6.536   0.41 103.20 ? 582  ARG A C   1 
ATOM   2216 O  O   . ARG A 1 319 ? -13.454 -25.042 7.280   0.41 102.85 ? 582  ARG A O   1 
ATOM   2217 C  CB  . ARG A 1 319 ? -11.733 -23.863 5.053   0.41 90.59  ? 582  ARG A CB  1 
ATOM   2218 C  CG  . ARG A 1 319 ? -10.278 -23.937 5.495   0.41 87.74  ? 582  ARG A CG  1 
ATOM   2219 C  CD  . ARG A 1 319 ? -9.454  -22.788 4.939   0.41 85.53  ? 582  ARG A CD  1 
ATOM   2220 N  NE  . ARG A 1 319 ? -10.138 -21.504 5.074   0.41 86.41  ? 582  ARG A NE  1 
ATOM   2221 C  CZ  . ARG A 1 319 ? -9.796  -20.515 5.901   0.41 86.01  ? 582  ARG A CZ  1 
ATOM   2222 N  NH1 . ARG A 1 319 ? -8.745  -20.619 6.699   0.41 87.17  ? 582  ARG A NH1 1 
ATOM   2223 N  NH2 . ARG A 1 319 ? -10.515 -19.406 5.921   0.41 84.27  ? 582  ARG A NH2 1 
ATOM   2224 N  N   . PRO A 1 320 ? -12.110 -26.818 6.968   1.00 117.61 ? 583  PRO A N   1 
ATOM   2225 C  CA  . PRO A 1 320 ? -12.388 -27.373 8.308   1.00 122.87 ? 583  PRO A CA  1 
ATOM   2226 C  C   . PRO A 1 320 ? -11.897 -26.623 9.568   1.00 122.93 ? 583  PRO A C   1 
ATOM   2227 O  O   . PRO A 1 320 ? -12.323 -26.974 10.672  1.00 121.18 ? 583  PRO A O   1 
ATOM   2228 C  CB  . PRO A 1 320 ? -11.685 -28.753 8.329   1.00 122.23 ? 583  PRO A CB  1 
ATOM   2229 C  CG  . PRO A 1 320 ? -11.024 -28.943 6.966   1.00 121.05 ? 583  PRO A CG  1 
ATOM   2230 C  CD  . PRO A 1 320 ? -11.132 -27.629 6.213   1.00 123.35 ? 583  PRO A CD  1 
ATOM   2231 N  N   . THR A 1 321 ? -11.019 -25.631 9.401   1.00 115.98 ? 584  THR A N   1 
ATOM   2232 C  CA  . THR A 1 321 ? -10.482 -24.762 10.484  1.00 119.37 ? 584  THR A CA  1 
ATOM   2233 C  C   . THR A 1 321 ? -11.641 -24.068 11.222  1.00 106.25 ? 584  THR A C   1 
ATOM   2234 O  O   . THR A 1 321 ? -11.530 -23.883 12.452  1.00 101.95 ? 584  THR A O   1 
ATOM   2235 C  CB  . THR A 1 321 ? -9.510  -23.743 9.881   1.00 138.82 ? 584  THR A CB  1 
ATOM   2236 O  OG1 . THR A 1 321 ? -10.262 -22.979 8.937   1.00 151.17 ? 584  THR A OG1 1 
ATOM   2237 C  CG2 . THR A 1 321 ? -8.317  -24.371 9.188   1.00 139.31 ? 584  THR A CG2 1 
ATOM   2238 N  N   . THR A 1 325 ? -15.213 -24.472 11.335  0.41 58.79  ? 588  THR A N   1 
ATOM   2239 C  CA  . THR A 1 325 ? -15.474 -24.676 9.882   0.41 63.99  ? 588  THR A CA  1 
ATOM   2240 C  C   . THR A 1 325 ? -16.099 -23.412 9.274   0.41 64.77  ? 588  THR A C   1 
ATOM   2241 O  O   . THR A 1 325 ? -17.235 -23.066 9.666   0.41 64.67  ? 588  THR A O   1 
ATOM   2242 C  CB  . THR A 1 325 ? -16.367 -25.901 9.638   0.41 63.21  ? 588  THR A CB  1 
ATOM   2243 O  OG1 . THR A 1 325 ? -15.676 -27.059 10.110  0.41 65.92  ? 588  THR A OG1 1 
ATOM   2244 C  CG2 . THR A 1 325 ? -16.721 -26.097 8.180   0.41 64.38  ? 588  THR A CG2 1 
ATOM   2245 N  N   . VAL A 1 326 ? -15.396 -22.772 8.333   0.41 64.70  ? 589  VAL A N   1 
ATOM   2246 C  CA  . VAL A 1 326 ? -15.849 -21.523 7.649   0.41 65.30  ? 589  VAL A CA  1 
ATOM   2247 C  C   . VAL A 1 326 ? -15.953 -21.781 6.140   0.41 63.35  ? 589  VAL A C   1 
ATOM   2248 O  O   . VAL A 1 326 ? -15.116 -22.532 5.600   0.41 60.20  ? 589  VAL A O   1 
ATOM   2249 C  CB  . VAL A 1 326 ? -14.924 -20.330 7.964   0.41 68.85  ? 589  VAL A CB  1 
ATOM   2250 C  CG1 . VAL A 1 326 ? -14.750 -20.138 9.465   0.41 73.43  ? 589  VAL A CG1 1 
ATOM   2251 C  CG2 . VAL A 1 326 ? -13.569 -20.444 7.282   0.41 72.66  ? 589  VAL A CG2 1 
ATOM   2252 N  N   . MET A 1 327 ? -16.964 -21.185 5.499   0.41 61.08  ? 590  MET A N   1 
ATOM   2253 C  CA  . MET A 1 327 ? -17.131 -21.148 4.022   0.41 58.81  ? 590  MET A CA  1 
ATOM   2254 C  C   . MET A 1 327 ? -16.361 -19.939 3.485   0.41 53.06  ? 590  MET A C   1 
ATOM   2255 O  O   . MET A 1 327 ? -16.690 -18.817 3.900   0.41 52.28  ? 590  MET A O   1 
ATOM   2256 C  CB  . MET A 1 327 ? -18.610 -21.021 3.634   0.41 60.34  ? 590  MET A CB  1 
ATOM   2257 C  CG  . MET A 1 327 ? -18.882 -21.206 2.147   0.41 58.97  ? 590  MET A CG  1 
ATOM   2258 S  SD  . MET A 1 327 ? -19.035 -22.946 1.659   0.41 58.87  ? 590  MET A SD  1 
ATOM   2259 C  CE  . MET A 1 327 ? -20.652 -23.356 2.316   0.41 59.23  ? 590  MET A CE  1 
ATOM   2260 N  N   . ASP A 1 328 ? -15.373 -20.167 2.614   0.41 50.32  ? 591  ASP A N   1 
ATOM   2261 C  CA  . ASP A 1 328 ? -14.610 -19.099 1.914   0.41 50.74  ? 591  ASP A CA  1 
ATOM   2262 C  C   . ASP A 1 328 ? -15.350 -18.724 0.628   0.41 52.00  ? 591  ASP A C   1 
ATOM   2263 O  O   . ASP A 1 328 ? -15.842 -19.635 -0.063  0.41 48.33  ? 591  ASP A O   1 
ATOM   2264 C  CB  . ASP A 1 328 ? -13.177 -19.525 1.574   0.41 49.56  ? 591  ASP A CB  1 
ATOM   2265 C  CG  . ASP A 1 328 ? -12.216 -19.534 2.752   0.41 48.71  ? 591  ASP A CG  1 
ATOM   2266 O  OD1 . ASP A 1 328 ? -12.301 -18.617 3.603   0.41 45.95  ? 591  ASP A OD1 1 
ATOM   2267 O  OD2 . ASP A 1 328 ? -11.378 -20.461 2.803   0.41 46.10  ? 591  ASP A OD2 1 
ATOM   2268 N  N   . ILE A 1 329 ? -15.410 -17.426 0.332   0.41 52.57  ? 592  ILE A N   1 
ATOM   2269 C  CA  . ILE A 1 329 ? -15.972 -16.862 -0.925  0.41 54.03  ? 592  ILE A CA  1 
ATOM   2270 C  C   . ILE A 1 329 ? -14.800 -16.298 -1.725  0.41 57.98  ? 592  ILE A C   1 
ATOM   2271 O  O   . ILE A 1 329 ? -14.337 -15.184 -1.402  0.41 59.24  ? 592  ILE A O   1 
ATOM   2272 C  CB  . ILE A 1 329 ? -17.049 -15.800 -0.627  0.41 55.86  ? 592  ILE A CB  1 
ATOM   2273 C  CG1 . ILE A 1 329 ? -18.187 -16.374 0.221   0.41 56.88  ? 592  ILE A CG1 1 
ATOM   2274 C  CG2 . ILE A 1 329 ? -17.561 -15.170 -1.913  0.41 56.22  ? 592  ILE A CG2 1 
ATOM   2275 C  CD1 . ILE A 1 329 ? -18.807 -17.635 -0.336  0.41 57.56  ? 592  ILE A CD1 1 
ATOM   2276 N  N   . ILE A 1 330 ? -14.358 -17.042 -2.742  1.00 61.99  ? 593  ILE A N   1 
ATOM   2277 C  CA  . ILE A 1 330 ? -13.129 -16.709 -3.508  1.00 61.51  ? 593  ILE A CA  1 
ATOM   2278 C  C   . ILE A 1 330 ? -13.530 -16.404 -4.952  1.00 59.07  ? 593  ILE A C   1 
ATOM   2279 O  O   . ILE A 1 330 ? -14.584 -16.872 -5.375  1.00 62.24  ? 593  ILE A O   1 
ATOM   2280 C  CB  . ILE A 1 330 ? -12.138 -17.880 -3.345  1.00 65.07  ? 593  ILE A CB  1 
ATOM   2281 C  CG1 . ILE A 1 330 ? -12.788 -19.234 -3.686  1.00 66.59  ? 593  ILE A CG1 1 
ATOM   2282 C  CG2 . ILE A 1 330 ? -11.566 -17.869 -1.928  1.00 58.63  ? 593  ILE A CG2 1 
ATOM   2283 C  CD1 . ILE A 1 330 ? -11.838 -20.426 -3.765  1.00 64.74  ? 593  ILE A CD1 1 
ATOM   2284 N  N   . SER A 1 331 ? -12.723 -15.626 -5.660  1.00 56.49  ? 594  SER A N   1 
ATOM   2285 C  CA  . SER A 1 331 ? -12.922 -15.375 -7.097  1.00 57.57  ? 594  SER A CA  1 
ATOM   2286 C  C   . SER A 1 331 ? -11.651 -15.682 -7.901  1.00 60.74  ? 594  SER A C   1 
ATOM   2287 O  O   . SER A 1 331 ? -10.549 -15.560 -7.348  1.00 52.90  ? 594  SER A O   1 
ATOM   2288 C  CB  . SER A 1 331 ? -13.389 -13.974 -7.304  1.00 56.10  ? 594  SER A CB  1 
ATOM   2289 O  OG  . SER A 1 331 ? -12.321 -13.054 -7.173  1.00 56.48  ? 594  SER A OG  1 
ATOM   2290 N  N   . ARG A 1 332 ? -11.794 -15.990 -9.194  1.00 54.51  ? 595  ARG A N   1 
ATOM   2291 C  CA  . ARG A 1 332 ? -10.660 -15.888 -10.143 1.00 52.99  ? 595  ARG A CA  1 
ATOM   2292 C  C   . ARG A 1 332 ? -11.188 -15.748 -11.554 1.00 55.11  ? 595  ARG A C   1 
ATOM   2293 O  O   . ARG A 1 332 ? -12.378 -16.018 -11.771 1.00 59.38  ? 595  ARG A O   1 
ATOM   2294 C  CB  . ARG A 1 332 ? -9.732  -17.100 -10.043 1.00 56.09  ? 595  ARG A CB  1 
ATOM   2295 C  CG  . ARG A 1 332 ? -10.099 -18.262 -10.936 1.00 57.37  ? 595  ARG A CG  1 
ATOM   2296 C  CD  . ARG A 1 332 ? -9.102  -19.384 -10.694 1.00 61.00  ? 595  ARG A CD  1 
ATOM   2297 N  NE  . ARG A 1 332 ? -7.747  -19.055 -11.146 1.00 56.13  ? 595  ARG A NE  1 
ATOM   2298 C  CZ  . ARG A 1 332 ? -6.638  -19.437 -10.524 1.00 59.66  ? 595  ARG A CZ  1 
ATOM   2299 N  NH1 . ARG A 1 332 ? -6.719  -20.135 -9.403  1.00 62.29  ? 595  ARG A NH1 1 
ATOM   2300 N  NH2 . ARG A 1 332 ? -5.452  -19.134 -11.023 1.00 62.07  ? 595  ARG A NH2 1 
ATOM   2301 N  N   . ARG A 1 333 ? -10.303 -15.362 -12.456 1.00 47.52  ? 596  ARG A N   1 
ATOM   2302 C  CA  . ARG A 1 333 ? -10.655 -15.030 -13.845 1.00 57.19  ? 596  ARG A CA  1 
ATOM   2303 C  C   . ARG A 1 333 ? -10.497 -16.250 -14.784 1.00 56.47  ? 596  ARG A C   1 
ATOM   2304 O  O   . ARG A 1 333 ? -11.360 -16.434 -15.671 1.00 63.88  ? 596  ARG A O   1 
ATOM   2305 C  CB  . ARG A 1 333 ? -9.837  -13.805 -14.248 1.00 57.46  ? 596  ARG A CB  1 
ATOM   2306 C  CG  . ARG A 1 333 ? -10.209 -12.558 -13.448 1.00 68.99  ? 596  ARG A CG  1 
ATOM   2307 C  CD  . ARG A 1 333 ? -10.337 -11.325 -14.342 1.00 76.42  ? 596  ARG A CD  1 
ATOM   2308 N  NE  . ARG A 1 333 ? -11.253 -11.566 -15.474 1.00 80.27  ? 596  ARG A NE  1 
ATOM   2309 C  CZ  . ARG A 1 333 ? -11.172 -11.015 -16.695 1.00 87.89  ? 596  ARG A CZ  1 
ATOM   2310 N  NH1 . ARG A 1 333 ? -10.216 -10.146 -16.997 1.00 97.71  ? 596  ARG A NH1 1 
ATOM   2311 N  NH2 . ARG A 1 333 ? -12.053 -11.347 -17.625 1.00 86.65  ? 596  ARG A NH2 1 
ATOM   2312 N  N   . ASP A 1 334 ? -9.428  -17.034 -14.622 0.41 52.44  ? 597  ASP A N   1 
ATOM   2313 C  CA  . ASP A 1 334 ? -9.032  -18.099 -15.587 0.41 52.26  ? 597  ASP A CA  1 
ATOM   2314 C  C   . ASP A 1 334 ? -9.302  -19.482 -14.974 0.41 48.77  ? 597  ASP A C   1 
ATOM   2315 O  O   . ASP A 1 334 ? -9.952  -19.540 -13.907 0.41 45.71  ? 597  ASP A O   1 
ATOM   2316 C  CB  . ASP A 1 334 ? -7.587  -17.896 -16.063 0.41 52.64  ? 597  ASP A CB  1 
ATOM   2317 C  CG  . ASP A 1 334 ? -6.542  -17.896 -14.961 0.41 53.61  ? 597  ASP A CG  1 
ATOM   2318 O  OD1 . ASP A 1 334 ? -6.929  -17.718 -13.788 0.41 55.26  ? 597  ASP A OD1 1 
ATOM   2319 O  OD2 . ASP A 1 334 ? -5.341  -18.061 -15.292 0.41 55.58  ? 597  ASP A OD2 1 
ATOM   2320 N  N   . GLN A 1 335 ? -8.839  -20.547 -15.647 0.41 45.86  ? 598  GLN A N   1 
ATOM   2321 C  CA  . GLN A 1 335 ? -9.123  -21.978 -15.343 0.41 44.16  ? 598  GLN A CA  1 
ATOM   2322 C  C   . GLN A 1 335 ? -10.566 -22.302 -15.753 0.41 45.19  ? 598  GLN A C   1 
ATOM   2323 O  O   . GLN A 1 335 ? -11.391 -21.367 -15.854 0.41 45.58  ? 598  GLN A O   1 
ATOM   2324 C  CB  . GLN A 1 335 ? -8.859  -22.309 -13.871 0.41 43.56  ? 598  GLN A CB  1 
ATOM   2325 C  CG  . GLN A 1 335 ? -7.526  -21.775 -13.364 0.41 44.44  ? 598  GLN A CG  1 
ATOM   2326 C  CD  . GLN A 1 335 ? -7.062  -22.411 -12.075 0.41 44.56  ? 598  GLN A CD  1 
ATOM   2327 O  OE1 . GLN A 1 335 ? -7.836  -23.018 -11.338 0.41 45.68  ? 598  GLN A OE1 1 
ATOM   2328 N  NE2 . GLN A 1 335 ? -5.778  -22.268 -11.795 0.41 42.93  ? 598  GLN A NE2 1 
ATOM   2329 N  N   . ARG A 1 336 ? -10.842 -23.583 -15.999 0.41 44.91  ? 599  ARG A N   1 
ATOM   2330 C  CA  . ARG A 1 336 ? -12.164 -24.090 -16.444 0.41 45.92  ? 599  ARG A CA  1 
ATOM   2331 C  C   . ARG A 1 336 ? -13.091 -24.198 -15.231 0.41 48.16  ? 599  ARG A C   1 
ATOM   2332 O  O   . ARG A 1 336 ? -12.775 -24.969 -14.303 0.41 50.19  ? 599  ARG A O   1 
ATOM   2333 C  CB  . ARG A 1 336 ? -12.023 -25.440 -17.156 0.41 45.22  ? 599  ARG A CB  1 
ATOM   2334 C  CG  . ARG A 1 336 ? -13.338 -26.064 -17.601 0.41 43.61  ? 599  ARG A CG  1 
ATOM   2335 C  CD  . ARG A 1 336 ? -13.892 -25.375 -18.834 0.41 43.03  ? 599  ARG A CD  1 
ATOM   2336 N  NE  . ARG A 1 336 ? -13.130 -25.730 -20.021 0.41 39.56  ? 599  ARG A NE  1 
ATOM   2337 C  CZ  . ARG A 1 336 ? -12.800 -24.893 -20.993 0.41 39.09  ? 599  ARG A CZ  1 
ATOM   2338 N  NH1 . ARG A 1 336 ? -13.150 -23.617 -20.931 0.41 40.35  ? 599  ARG A NH1 1 
ATOM   2339 N  NH2 . ARG A 1 336 ? -12.109 -25.338 -22.028 0.41 38.09  ? 599  ARG A NH2 1 
ATOM   2340 N  N   . GLY A 1 337 ? -14.182 -23.428 -15.267 0.41 51.47  ? 600  GLY A N   1 
ATOM   2341 C  CA  . GLY A 1 337 ? -15.324 -23.490 -14.337 0.41 52.41  ? 600  GLY A CA  1 
ATOM   2342 C  C   . GLY A 1 337 ? -16.619 -23.371 -15.118 0.41 53.93  ? 600  GLY A C   1 
ATOM   2343 O  O   . GLY A 1 337 ? -16.967 -22.240 -15.524 0.41 58.21  ? 600  GLY A O   1 
ATOM   2344 N  N   . SER A 1 338 ? -17.264 -24.510 -15.385 0.41 51.97  ? 601  SER A N   1 
ATOM   2345 C  CA  . SER A 1 338 ? -18.546 -24.620 -16.126 0.41 48.00  ? 601  SER A CA  1 
ATOM   2346 C  C   . SER A 1 338 ? -19.133 -26.019 -15.924 0.41 46.88  ? 601  SER A C   1 
ATOM   2347 O  O   . SER A 1 338 ? -18.439 -26.874 -15.333 0.41 48.02  ? 601  SER A O   1 
ATOM   2348 C  CB  . SER A 1 338 ? -18.350 -24.299 -17.589 0.41 49.57  ? 601  SER A CB  1 
ATOM   2349 O  OG  . SER A 1 338 ? -17.359 -25.131 -18.182 0.41 49.23  ? 601  SER A OG  1 
ATOM   2350 N  N   . GLY A 1 339 ? -20.364 -26.239 -16.393 0.41 47.82  ? 602  GLY A N   1 
ATOM   2351 C  CA  . GLY A 1 339 ? -21.035 -27.554 -16.367 0.41 47.24  ? 602  GLY A CA  1 
ATOM   2352 C  C   . GLY A 1 339 ? -20.234 -28.572 -17.157 0.41 44.44  ? 602  GLY A C   1 
ATOM   2353 O  O   . GLY A 1 339 ? -19.586 -28.160 -18.134 0.41 41.42  ? 602  GLY A O   1 
ATOM   2354 N  N   . GLN A 1 340 ? -20.277 -29.846 -16.752 0.41 43.34  ? 603  GLN A N   1 
ATOM   2355 C  CA  . GLN A 1 340 ? -19.410 -30.921 -17.310 0.41 43.32  ? 603  GLN A CA  1 
ATOM   2356 C  C   . GLN A 1 340 ? -19.586 -30.991 -18.833 0.41 39.37  ? 603  GLN A C   1 
ATOM   2357 O  O   . GLN A 1 340 ? -18.570 -31.070 -19.529 0.41 34.57  ? 603  GLN A O   1 
ATOM   2358 C  CB  . GLN A 1 340 ? -19.661 -32.280 -16.644 0.41 46.99  ? 603  GLN A CB  1 
ATOM   2359 C  CG  . GLN A 1 340 ? -21.119 -32.566 -16.285 0.41 52.14  ? 603  GLN A CG  1 
ATOM   2360 C  CD  . GLN A 1 340 ? -21.400 -34.036 -16.046 0.41 53.65  ? 603  GLN A CD  1 
ATOM   2361 O  OE1 . GLN A 1 340 ? -20.487 -34.864 -15.992 0.41 54.45  ? 603  GLN A OE1 1 
ATOM   2362 N  NE2 . GLN A 1 340 ? -22.674 -34.382 -15.913 0.41 55.41  ? 603  GLN A NE2 1 
ATOM   2363 N  N   . VAL A 1 341 ? -20.820 -30.925 -19.339 0.41 40.49  ? 604  VAL A N   1 
ATOM   2364 C  CA  . VAL A 1 341 ? -21.118 -31.210 -20.776 0.41 38.35  ? 604  VAL A CA  1 
ATOM   2365 C  C   . VAL A 1 341 ? -20.639 -30.036 -21.639 0.41 37.44  ? 604  VAL A C   1 
ATOM   2366 O  O   . VAL A 1 341 ? -20.123 -30.296 -22.749 0.41 33.95  ? 604  VAL A O   1 
ATOM   2367 C  CB  . VAL A 1 341 ? -22.608 -31.517 -21.009 0.41 38.69  ? 604  VAL A CB  1 
ATOM   2368 C  CG1 . VAL A 1 341 ? -22.905 -31.695 -22.493 0.41 39.69  ? 604  VAL A CG1 1 
ATOM   2369 C  CG2 . VAL A 1 341 ? -23.061 -32.740 -20.217 0.41 38.75  ? 604  VAL A CG2 1 
ATOM   2370 N  N   . VAL A 1 342 ? -20.811 -28.793 -21.171 0.41 36.56  ? 605  VAL A N   1 
ATOM   2371 C  CA  . VAL A 1 342 ? -20.235 -27.607 -21.869 0.41 35.96  ? 605  VAL A CA  1 
ATOM   2372 C  C   . VAL A 1 342 ? -18.711 -27.708 -21.774 0.41 32.97  ? 605  VAL A C   1 
ATOM   2373 O  O   . VAL A 1 342 ? -18.064 -27.627 -22.820 0.41 32.49  ? 605  VAL A O   1 
ATOM   2374 C  CB  . VAL A 1 342 ? -20.781 -26.278 -21.314 0.41 37.00  ? 605  VAL A CB  1 
ATOM   2375 C  CG1 . VAL A 1 342 ? -20.149 -25.078 -22.004 0.41 35.63  ? 605  VAL A CG1 1 
ATOM   2376 C  CG2 . VAL A 1 342 ? -22.297 -26.226 -21.438 0.41 37.40  ? 605  VAL A CG2 1 
ATOM   2377 N  N   . THR A 1 343 ? -18.175 -27.937 -20.573 0.41 32.32  ? 606  THR A N   1 
ATOM   2378 C  CA  . THR A 1 343 ? -16.720 -28.131 -20.324 0.41 32.67  ? 606  THR A CA  1 
ATOM   2379 C  C   . THR A 1 343 ? -16.158 -29.170 -21.302 0.41 30.71  ? 606  THR A C   1 
ATOM   2380 O  O   . THR A 1 343 ? -15.067 -28.926 -21.834 0.41 33.25  ? 606  THR A O   1 
ATOM   2381 C  CB  . THR A 1 343 ? -16.439 -28.518 -18.867 0.41 32.97  ? 606  THR A CB  1 
ATOM   2382 O  OG1 . THR A 1 343 ? -16.709 -27.358 -18.083 0.41 35.90  ? 606  THR A OG1 1 
ATOM   2383 C  CG2 . THR A 1 343 ? -15.015 -28.976 -18.633 0.41 34.62  ? 606  THR A CG2 1 
ATOM   2384 N  N   . TYR A 1 344 ? -16.877 -30.273 -21.538 1.00 29.61  ? 607  TYR A N   1 
ATOM   2385 C  CA  . TYR A 1 344 ? -16.454 -31.290 -22.507 1.00 29.46  ? 607  TYR A CA  1 
ATOM   2386 C  C   . TYR A 1 344 ? -16.256 -30.639 -23.887 1.00 29.54  ? 607  TYR A C   1 
ATOM   2387 O  O   . TYR A 1 344 ? -15.195 -30.857 -24.505 1.00 26.09  ? 607  TYR A O   1 
ATOM   2388 C  CB  . TYR A 1 344 ? -17.417 -32.467 -22.562 1.00 30.85  ? 607  TYR A CB  1 
ATOM   2389 C  CG  . TYR A 1 344 ? -17.030 -33.489 -23.594 1.00 28.28  ? 607  TYR A CG  1 
ATOM   2390 C  CD1 . TYR A 1 344 ? -16.060 -34.435 -23.307 1.00 31.07  ? 607  TYR A CD1 1 
ATOM   2391 C  CD2 . TYR A 1 344 ? -17.561 -33.454 -24.868 1.00 28.33  ? 607  TYR A CD2 1 
ATOM   2392 C  CE1 . TYR A 1 344 ? -15.681 -35.362 -24.263 1.00 30.55  ? 607  TYR A CE1 1 
ATOM   2393 C  CE2 . TYR A 1 344 ? -17.232 -34.400 -25.811 1.00 34.54  ? 607  TYR A CE2 1 
ATOM   2394 C  CZ  . TYR A 1 344 ? -16.269 -35.351 -25.509 1.00 31.99  ? 607  TYR A CZ  1 
ATOM   2395 O  OH  . TYR A 1 344 ? -15.866 -36.236 -26.470 1.00 38.41  ? 607  TYR A OH  1 
ATOM   2396 N  N   . GLY A 1 345 ? -17.238 -29.873 -24.363 1.00 24.49  ? 608  GLY A N   1 
ATOM   2397 C  CA  . GLY A 1 345 ? -17.210 -29.317 -25.730 1.00 26.14  ? 608  GLY A CA  1 
ATOM   2398 C  C   . GLY A 1 345 ? -16.129 -28.242 -25.829 1.00 22.92  ? 608  GLY A C   1 
ATOM   2399 O  O   . GLY A 1 345 ? -15.413 -28.244 -26.797 1.00 29.58  ? 608  GLY A O   1 
ATOM   2400 N  N   . LEU A 1 346 ? -15.949 -27.420 -24.802 1.00 23.73  ? 609  LEU A N   1 
ATOM   2401 C  CA  . LEU A 1 346 ? -14.977 -26.322 -24.904 1.00 29.45  ? 609  LEU A CA  1 
ATOM   2402 C  C   . LEU A 1 346 ? -13.542 -26.896 -24.727 1.00 27.45  ? 609  LEU A C   1 
ATOM   2403 O  O   . LEU A 1 346 ? -12.641 -26.366 -25.398 1.00 28.79  ? 609  LEU A O   1 
ATOM   2404 C  CB  . LEU A 1 346 ? -15.297 -25.237 -23.872 1.00 29.19  ? 609  LEU A CB  1 
ATOM   2405 C  CG  . LEU A 1 346 ? -16.598 -24.469 -24.052 1.00 28.58  ? 609  LEU A CG  1 
ATOM   2406 C  CD1 . LEU A 1 346 ? -16.670 -23.376 -23.012 1.00 36.02  ? 609  LEU A CD1 1 
ATOM   2407 C  CD2 . LEU A 1 346 ? -16.727 -23.907 -25.469 1.00 29.14  ? 609  LEU A CD2 1 
ATOM   2408 N  N   . ASN A 1 347 ? -13.366 -27.912 -23.876 1.00 29.19  ? 610  ASN A N   1 
ATOM   2409 C  CA  . ASN A 1 347 ? -12.103 -28.697 -23.785 1.00 25.86  ? 610  ASN A CA  1 
ATOM   2410 C  C   . ASN A 1 347 ? -11.796 -29.296 -25.159 1.00 23.73  ? 610  ASN A C   1 
ATOM   2411 O  O   . ASN A 1 347 ? -10.680 -29.090 -25.643 1.00 25.20  ? 610  ASN A O   1 
ATOM   2412 C  CB  . ASN A 1 347 ? -12.155 -29.762 -22.688 1.00 24.52  ? 610  ASN A CB  1 
ATOM   2413 C  CG  . ASN A 1 347 ? -12.027 -29.168 -21.303 1.00 26.79  ? 610  ASN A CG  1 
ATOM   2414 O  OD1 . ASN A 1 347 ? -11.647 -28.024 -21.134 1.00 26.85  ? 610  ASN A OD1 1 
ATOM   2415 N  ND2 . ASN A 1 347 ? -12.205 -29.977 -20.278 1.00 28.95  ? 610  ASN A ND2 1 
ATOM   2416 N  N   . THR A 1 348 ? -12.726 -29.976 -25.821 1.00 22.01  ? 611  THR A N   1 
ATOM   2417 C  CA  . THR A 1 348 ? -12.489 -30.538 -27.174 1.00 22.03  ? 611  THR A CA  1 
ATOM   2418 C  C   . THR A 1 348 ? -12.006 -29.436 -28.115 1.00 24.35  ? 611  THR A C   1 
ATOM   2419 O  O   . THR A 1 348 ? -10.999 -29.640 -28.880 1.00 24.47  ? 611  THR A O   1 
ATOM   2420 C  CB  . THR A 1 348 ? -13.713 -31.255 -27.694 1.00 20.88  ? 611  THR A CB  1 
ATOM   2421 O  OG1 . THR A 1 348 ? -14.141 -32.259 -26.778 1.00 26.28  ? 611  THR A OG1 1 
ATOM   2422 C  CG2 . THR A 1 348 ? -13.480 -31.863 -29.028 1.00 20.13  ? 611  THR A CG2 1 
ATOM   2423 N  N   . PHE A 1 349 ? -12.683 -28.282 -28.101 0.41 25.94  ? 612  PHE A N   1 
ATOM   2424 C  CA  . PHE A 1 349 ? -12.388 -27.145 -29.015 0.41 26.28  ? 612  PHE A CA  1 
ATOM   2425 C  C   . PHE A 1 349 ? -10.952 -26.648 -28.799 0.41 25.08  ? 612  PHE A C   1 
ATOM   2426 O  O   . PHE A 1 349 ? -10.206 -26.506 -29.783 0.41 26.29  ? 612  PHE A O   1 
ATOM   2427 C  CB  . PHE A 1 349 ? -13.379 -25.997 -28.801 0.41 27.53  ? 612  PHE A CB  1 
ATOM   2428 C  CG  . PHE A 1 349 ? -13.065 -24.777 -29.622 0.41 27.49  ? 612  PHE A CG  1 
ATOM   2429 C  CD1 . PHE A 1 349 ? -13.536 -24.659 -30.921 0.41 28.90  ? 612  PHE A CD1 1 
ATOM   2430 C  CD2 . PHE A 1 349 ? -12.286 -23.756 -29.103 0.41 26.98  ? 612  PHE A CD2 1 
ATOM   2431 C  CE1 . PHE A 1 349 ? -13.233 -23.542 -31.686 0.41 28.29  ? 612  PHE A CE1 1 
ATOM   2432 C  CE2 . PHE A 1 349 ? -11.999 -22.631 -29.866 0.41 28.62  ? 612  PHE A CE2 1 
ATOM   2433 C  CZ  . PHE A 1 349 ? -12.463 -22.531 -31.155 0.41 28.28  ? 612  PHE A CZ  1 
ATOM   2434 N  N   . THR A 1 350 ? -10.590 -26.366 -27.549 1.00 23.24  ? 613  THR A N   1 
ATOM   2435 C  CA  . THR A 1 350 ? -9.309  -25.737 -27.225 1.00 27.98  ? 613  THR A CA  1 
ATOM   2436 C  C   . THR A 1 350 ? -8.213  -26.798 -27.447 1.00 27.16  ? 613  THR A C   1 
ATOM   2437 O  O   . THR A 1 350 ? -7.134  -26.444 -27.937 1.00 28.18  ? 613  THR A O   1 
ATOM   2438 C  CB  . THR A 1 350 ? -9.362  -25.126 -25.832 1.00 32.75  ? 613  THR A CB  1 
ATOM   2439 O  OG1 . THR A 1 350 ? -10.290 -24.042 -25.949 1.00 32.50  ? 613  THR A OG1 1 
ATOM   2440 C  CG2 . THR A 1 350 ? -7.985  -24.671 -25.397 1.00 35.47  ? 613  THR A CG2 1 
ATOM   2441 N  N   . ASN A 1 351 ? -8.518  -28.080 -27.184 1.00 25.44  ? 614  ASN A N   1 
ATOM   2442 C  CA  . ASN A 1 351 ? -7.559  -29.190 -27.443 1.00 25.16  ? 614  ASN A CA  1 
ATOM   2443 C  C   . ASN A 1 351 ? -7.351  -29.301 -28.960 1.00 26.51  ? 614  ASN A C   1 
ATOM   2444 O  O   . ASN A 1 351 ? -6.202  -29.472 -29.407 1.00 26.12  ? 614  ASN A O   1 
ATOM   2445 C  CB  . ASN A 1 351 ? -7.978  -30.484 -26.763 1.00 23.84  ? 614  ASN A CB  1 
ATOM   2446 C  CG  . ASN A 1 351 ? -6.781  -31.395 -26.496 1.00 29.98  ? 614  ASN A CG  1 
ATOM   2447 O  OD1 . ASN A 1 351 ? -5.620  -31.044 -26.787 1.00 27.50  ? 614  ASN A OD1 1 
ATOM   2448 N  ND2 . ASN A 1 351 ? -7.058  -32.570 -25.952 1.00 28.47  ? 614  ASN A ND2 1 
ATOM   2449 N  N   . MET A 1 352 ? -8.414  -29.177 -29.748 1.00 23.12  ? 615  MET A N   1 
ATOM   2450 C  CA  . MET A 1 352 ? -8.274  -29.274 -31.225 1.00 27.31  ? 615  MET A CA  1 
ATOM   2451 C  C   . MET A 1 352 ? -7.347  -28.138 -31.700 1.00 28.55  ? 615  MET A C   1 
ATOM   2452 O  O   . MET A 1 352 ? -6.478  -28.357 -32.568 1.00 27.70  ? 615  MET A O   1 
ATOM   2453 C  CB  . MET A 1 352 ? -9.617  -29.160 -31.953 1.00 27.63  ? 615  MET A CB  1 
ATOM   2454 C  CG  . MET A 1 352 ? -10.411 -30.421 -31.883 1.00 27.92  ? 615  MET A CG  1 
ATOM   2455 S  SD  . MET A 1 352 ? -12.121 -30.113 -32.543 1.00 31.54  ? 615  MET A SD  1 
ATOM   2456 C  CE  . MET A 1 352 ? -11.876 -29.937 -34.282 1.00 29.16  ? 615  MET A CE  1 
ATOM   2457 N  N   . GLU A 1 353 ? -7.554  -26.946 -31.140 0.41 28.08  ? 616  GLU A N   1 
ATOM   2458 C  CA  . GLU A 1 353 ? -6.789  -25.706 -31.446 0.41 29.40  ? 616  GLU A CA  1 
ATOM   2459 C  C   . GLU A 1 353 ? -5.307  -25.937 -31.106 0.41 27.98  ? 616  GLU A C   1 
ATOM   2460 O  O   . GLU A 1 353 ? -4.465  -25.699 -31.974 0.41 27.85  ? 616  GLU A O   1 
ATOM   2461 C  CB  . GLU A 1 353 ? -7.405  -24.552 -30.655 0.41 30.35  ? 616  GLU A CB  1 
ATOM   2462 C  CG  . GLU A 1 353 ? -6.648  -23.239 -30.723 0.41 32.93  ? 616  GLU A CG  1 
ATOM   2463 C  CD  . GLU A 1 353 ? -7.073  -22.278 -29.620 0.41 34.12  ? 616  GLU A CD  1 
ATOM   2464 O  OE1 . GLU A 1 353 ? -8.263  -21.893 -29.610 0.41 36.51  ? 616  GLU A OE1 1 
ATOM   2465 O  OE2 . GLU A 1 353 ? -6.234  -21.961 -28.740 0.41 32.77  ? 616  GLU A OE2 1 
ATOM   2466 N  N   . ALA A 1 354 ? -5.018  -26.377 -29.878 1.00 27.67  ? 617  ALA A N   1 
ATOM   2467 C  CA  . ALA A 1 354 ? -3.648  -26.623 -29.390 1.00 27.47  ? 617  ALA A CA  1 
ATOM   2468 C  C   . ALA A 1 354 ? -2.936  -27.646 -30.266 1.00 29.96  ? 617  ALA A C   1 
ATOM   2469 O  O   . ALA A 1 354 ? -1.760  -27.425 -30.610 1.00 27.69  ? 617  ALA A O   1 
ATOM   2470 C  CB  . ALA A 1 354 ? -3.707  -27.080 -27.997 1.00 27.73  ? 617  ALA A CB  1 
ATOM   2471 N  N   . GLN A 1 355 ? -3.615  -28.719 -30.666 1.00 24.44  ? 618  GLN A N   1 
ATOM   2472 C  CA  . GLN A 1 355 ? -2.929  -29.778 -31.418 1.00 27.75  ? 618  GLN A CA  1 
ATOM   2473 C  C   . GLN A 1 355 ? -2.704  -29.334 -32.861 1.00 27.41  ? 618  GLN A C   1 
ATOM   2474 O  O   . GLN A 1 355 ? -1.708  -29.797 -33.479 1.00 27.48  ? 618  GLN A O   1 
ATOM   2475 C  CB  . GLN A 1 355 ? -3.685  -31.107 -31.319 1.00 27.22  ? 618  GLN A CB  1 
ATOM   2476 C  CG  . GLN A 1 355 ? -3.926  -31.619 -29.914 1.00 24.96  ? 618  GLN A CG  1 
ATOM   2477 C  CD  . GLN A 1 355 ? -2.651  -31.772 -29.135 1.00 29.17  ? 618  GLN A CD  1 
ATOM   2478 O  OE1 . GLN A 1 355 ? -1.592  -32.149 -29.635 1.00 29.42  ? 618  GLN A OE1 1 
ATOM   2479 N  NE2 . GLN A 1 355 ? -2.756  -31.471 -27.869 1.00 30.29  ? 618  GLN A NE2 1 
ATOM   2480 N  N   . LEU A 1 356 ? -3.578  -28.535 -33.481 1.00 28.71  ? 619  LEU A N   1 
ATOM   2481 C  CA  . LEU A 1 356 ? -3.306  -27.976 -34.849 1.00 26.32  ? 619  LEU A CA  1 
ATOM   2482 C  C   . LEU A 1 356 ? -2.062  -27.054 -34.788 1.00 28.85  ? 619  LEU A C   1 
ATOM   2483 O  O   . LEU A 1 356 ? -1.269  -27.103 -35.707 1.00 28.97  ? 619  LEU A O   1 
ATOM   2484 C  CB  . LEU A 1 356 ? -4.487  -27.121 -35.349 1.00 29.71  ? 619  LEU A CB  1 
ATOM   2485 C  CG  . LEU A 1 356 ? -5.613  -27.848 -36.048 1.00 29.12  ? 619  LEU A CG  1 
ATOM   2486 C  CD1 . LEU A 1 356 ? -6.744  -26.885 -36.419 1.00 33.83  ? 619  LEU A CD1 1 
ATOM   2487 C  CD2 . LEU A 1 356 ? -5.148  -28.581 -37.288 1.00 32.09  ? 619  LEU A CD2 1 
ATOM   2488 N  N   . ILE A 1 357 ? -1.906  -26.265 -33.741 1.00 24.18  ? 620  ILE A N   1 
ATOM   2489 C  CA  . ILE A 1 357 ? -0.738  -25.365 -33.566 1.00 29.34  ? 620  ILE A CA  1 
ATOM   2490 C  C   . ILE A 1 357 ? 0.508   -26.244 -33.371 1.00 33.40  ? 620  ILE A C   1 
ATOM   2491 O  O   . ILE A 1 357 ? 1.444   -26.049 -34.150 1.00 30.38  ? 620  ILE A O   1 
ATOM   2492 C  CB  . ILE A 1 357 ? -0.978  -24.359 -32.443 1.00 29.93  ? 620  ILE A CB  1 
ATOM   2493 C  CG1 . ILE A 1 357 ? -2.139  -23.423 -32.836 1.00 30.88  ? 620  ILE A CG1 1 
ATOM   2494 C  CG2 . ILE A 1 357 ? 0.282   -23.566 -32.135 1.00 34.17  ? 620  ILE A CG2 1 
ATOM   2495 C  CD1 . ILE A 1 357 ? -2.712  -22.632 -31.703 1.00 30.49  ? 620  ILE A CD1 1 
ATOM   2496 N  N   . ARG A 1 358 ? 0.430   -27.321 -32.572 1.00 29.08  ? 621  ARG A N   1 
ATOM   2497 C  CA  . ARG A 1 358 ? 1.594   -28.203 -32.391 1.00 29.54  ? 621  ARG A CA  1 
ATOM   2498 C  C   . ARG A 1 358 ? 1.947   -28.828 -33.732 1.00 29.87  ? 621  ARG A C   1 
ATOM   2499 O  O   . ARG A 1 358 ? 3.184   -28.880 -34.061 1.00 30.09  ? 621  ARG A O   1 
ATOM   2500 C  CB  . ARG A 1 358 ? 1.421   -29.222 -31.261 1.00 32.54  ? 621  ARG A CB  1 
ATOM   2501 C  CG  . ARG A 1 358 ? 2.668   -30.080 -31.102 1.00 28.63  ? 621  ARG A CG  1 
ATOM   2502 C  CD  . ARG A 1 358 ? 2.581   -30.934 -29.855 1.00 27.89  ? 621  ARG A CD  1 
ATOM   2503 N  NE  . ARG A 1 358 ? 3.727   -31.837 -29.811 1.00 29.32  ? 621  ARG A NE  1 
ATOM   2504 C  CZ  . ARG A 1 358 ? 3.892   -32.819 -28.928 1.00 30.55  ? 621  ARG A CZ  1 
ATOM   2505 N  NH1 . ARG A 1 358 ? 2.932   -33.149 -28.084 1.00 27.07  ? 621  ARG A NH1 1 
ATOM   2506 N  NH2 . ARG A 1 358 ? 5.017   -33.522 -28.936 1.00 34.90  ? 621  ARG A NH2 1 
ATOM   2507 N  N   . GLN A 1 359 ? 0.961   -29.242 -34.525 1.00 27.29  ? 622  GLN A N   1 
ATOM   2508 C  CA  . GLN A 1 359 ? 1.196   -29.730 -35.891 1.00 25.32  ? 622  GLN A CA  1 
ATOM   2509 C  C   . GLN A 1 359 ? 1.877   -28.592 -36.725 1.00 31.13  ? 622  GLN A C   1 
ATOM   2510 O  O   . GLN A 1 359 ? 2.849   -28.886 -37.515 1.00 37.89  ? 622  GLN A O   1 
ATOM   2511 C  CB  . GLN A 1 359 ? -0.060  -30.280 -36.572 1.00 26.52  ? 622  GLN A CB  1 
ATOM   2512 C  CG  . GLN A 1 359 ? -0.602  -31.590 -36.029 1.00 27.58  ? 622  GLN A CG  1 
ATOM   2513 C  CD  . GLN A 1 359 ? -1.575  -32.237 -36.975 1.00 28.52  ? 622  GLN A CD  1 
ATOM   2514 O  OE1 . GLN A 1 359 ? -1.222  -32.762 -38.041 1.00 27.97  ? 622  GLN A OE1 1 
ATOM   2515 N  NE2 . GLN A 1 359 ? -2.837  -32.260 -36.548 1.00 31.44  ? 622  GLN A NE2 1 
ATOM   2516 N  N   . MET A 1 360 ? 1.429   -27.354 -36.640 1.00 29.12  ? 623  MET A N   1 
ATOM   2517 C  CA  . MET A 1 360 ? 2.007   -26.229 -37.453 1.00 33.31  ? 623  MET A CA  1 
ATOM   2518 C  C   . MET A 1 360 ? 3.508   -26.093 -37.060 1.00 31.92  ? 623  MET A C   1 
ATOM   2519 O  O   . MET A 1 360 ? 4.323   -26.044 -37.960 1.00 34.15  ? 623  MET A O   1 
ATOM   2520 C  CB  . MET A 1 360 ? 1.301   -24.894 -37.186 1.00 33.31  ? 623  MET A CB  1 
ATOM   2521 C  CG  . MET A 1 360 ? -0.027  -24.713 -37.895 1.00 40.72  ? 623  MET A CG  1 
ATOM   2522 S  SD  . MET A 1 360 ? -0.731  -23.179 -37.289 1.00 42.11  ? 623  MET A SD  1 
ATOM   2523 C  CE  . MET A 1 360 ? -2.484  -23.547 -37.344 1.00 45.73  ? 623  MET A CE  1 
ATOM   2524 N  N   . GLU A 1 361 ? 3.822   -26.101 -35.771 1.00 29.03  ? 624  GLU A N   1 
ATOM   2525 C  CA  . GLU A 1 361 ? 5.206   -26.027 -35.273 1.00 33.05  ? 624  GLU A CA  1 
ATOM   2526 C  C   . GLU A 1 361 ? 6.030   -27.175 -35.848 1.00 39.14  ? 624  GLU A C   1 
ATOM   2527 O  O   . GLU A 1 361 ? 7.107   -26.916 -36.384 1.00 34.07  ? 624  GLU A O   1 
ATOM   2528 C  CB  . GLU A 1 361 ? 5.252   -26.063 -33.754 1.00 33.99  ? 624  GLU A CB  1 
ATOM   2529 C  CG  . GLU A 1 361 ? 6.576   -25.604 -33.218 1.00 37.58  ? 624  GLU A CG  1 
ATOM   2530 C  CD  . GLU A 1 361 ? 6.654   -25.408 -31.720 1.00 40.90  ? 624  GLU A CD  1 
ATOM   2531 O  OE1 . GLU A 1 361 ? 7.782   -25.453 -31.177 1.00 42.72  ? 624  GLU A OE1 1 
ATOM   2532 O  OE2 . GLU A 1 361 ? 5.593   -25.187 -31.077 1.00 42.49  ? 624  GLU A OE2 1 
ATOM   2533 N  N   . GLY A 1 362 ? 5.581   -28.418 -35.759 1.00 31.04  ? 625  GLY A N   1 
ATOM   2534 C  CA  . GLY A 1 362 ? 6.371   -29.518 -36.321 1.00 35.03  ? 625  GLY A CA  1 
ATOM   2535 C  C   . GLY A 1 362 ? 6.635   -29.309 -37.823 1.00 41.05  ? 625  GLY A C   1 
ATOM   2536 O  O   . GLY A 1 362 ? 7.684   -29.801 -38.323 1.00 38.06  ? 625  GLY A O   1 
ATOM   2537 N  N   . GLU A 1 363 ? 5.702   -28.676 -38.539 1.00 32.27  ? 626  GLU A N   1 
ATOM   2538 C  CA  . GLU A 1 363 ? 5.761   -28.583 -40.014 1.00 34.92  ? 626  GLU A CA  1 
ATOM   2539 C  C   . GLU A 1 363 ? 6.585   -27.330 -40.405 1.00 35.85  ? 626  GLU A C   1 
ATOM   2540 O  O   . GLU A 1 363 ? 6.740   -27.093 -41.579 1.00 35.91  ? 626  GLU A O   1 
ATOM   2541 C  CB  . GLU A 1 363 ? 4.353   -28.587 -40.631 1.00 34.76  ? 626  GLU A CB  1 
ATOM   2542 C  CG  . GLU A 1 363 ? 3.776   -30.013 -40.749 1.00 35.64  ? 626  GLU A CG  1 
ATOM   2543 C  CD  . GLU A 1 363 ? 2.381   -30.116 -41.327 1.00 40.67  ? 626  GLU A CD  1 
ATOM   2544 O  OE1 . GLU A 1 363 ? 2.193   -29.544 -42.448 1.00 34.63  ? 626  GLU A OE1 1 
ATOM   2545 O  OE2 . GLU A 1 363 ? 1.481   -30.759 -40.657 1.00 32.31  ? 626  GLU A OE2 1 
ATOM   2546 N  N   . GLY A 1 364 ? 7.055   -26.542 -39.457 1.00 29.59  ? 627  GLY A N   1 
ATOM   2547 C  CA  . GLY A 1 364 ? 7.839   -25.330 -39.771 1.00 40.19  ? 627  GLY A CA  1 
ATOM   2548 C  C   . GLY A 1 364 ? 7.000   -24.179 -40.300 1.00 49.60  ? 627  GLY A C   1 
ATOM   2549 O  O   . GLY A 1 364 ? 7.596   -23.335 -41.009 1.00 47.60  ? 627  GLY A O   1 
ATOM   2550 N  N   . VAL A 1 365 ? 5.687   -24.093 -39.986 1.00 36.09  ? 628  VAL A N   1 
ATOM   2551 C  CA  . VAL A 1 365 ? 4.802   -23.026 -40.550 1.00 38.71  ? 628  VAL A CA  1 
ATOM   2552 C  C   . VAL A 1 365 ? 5.251   -21.672 -39.991 1.00 37.66  ? 628  VAL A C   1 
ATOM   2553 O  O   . VAL A 1 365 ? 5.176   -20.688 -40.707 1.00 46.20  ? 628  VAL A O   1 
ATOM   2554 C  CB  . VAL A 1 365 ? 3.312   -23.325 -40.275 1.00 35.89  ? 628  VAL A CB  1 
ATOM   2555 C  CG1 . VAL A 1 365 ? 2.387   -22.221 -40.770 1.00 39.96  ? 628  VAL A CG1 1 
ATOM   2556 C  CG2 . VAL A 1 365 ? 2.923   -24.623 -40.946 1.00 40.88  ? 628  VAL A CG2 1 
ATOM   2557 N  N   . PHE A 1 366 ? 5.635   -21.634 -38.723 1.00 44.39  ? 629  PHE A N   1 
ATOM   2558 C  CA  . PHE A 1 366 ? 6.182   -20.451 -38.020 1.00 45.88  ? 629  PHE A CA  1 
ATOM   2559 C  C   . PHE A 1 366 ? 7.512   -20.843 -37.349 1.00 54.46  ? 629  PHE A C   1 
ATOM   2560 O  O   . PHE A 1 366 ? 7.754   -22.025 -37.115 1.00 55.81  ? 629  PHE A O   1 
ATOM   2561 C  CB  . PHE A 1 366 ? 5.125   -19.936 -37.051 1.00 44.91  ? 629  PHE A CB  1 
ATOM   2562 C  CG  . PHE A 1 366 ? 4.909   -20.791 -35.838 1.00 43.96  ? 629  PHE A CG  1 
ATOM   2563 C  CD1 . PHE A 1 366 ? 3.986   -21.816 -35.870 1.00 42.58  ? 629  PHE A CD1 1 
ATOM   2564 C  CD2 . PHE A 1 366 ? 5.596   -20.549 -34.661 1.00 44.27  ? 629  PHE A CD2 1 
ATOM   2565 C  CE1 . PHE A 1 366 ? 3.777   -22.610 -34.757 1.00 38.60  ? 629  PHE A CE1 1 
ATOM   2566 C  CE2 . PHE A 1 366 ? 5.382   -21.347 -33.553 1.00 48.55  ? 629  PHE A CE2 1 
ATOM   2567 C  CZ  . PHE A 1 366 ? 4.477   -22.389 -33.610 1.00 39.22  ? 629  PHE A CZ  1 
ATOM   2568 N  N   . LYS A 1 367 ? 8.391   -19.876 -37.084 1.00 57.25  ? 630  LYS A N   1 
ATOM   2569 C  CA  . LYS A 1 367 ? 9.777   -20.139 -36.637 1.00 55.52  ? 630  LYS A CA  1 
ATOM   2570 C  C   . LYS A 1 367 ? 9.854   -19.928 -35.131 1.00 49.94  ? 630  LYS A C   1 
ATOM   2571 O  O   . LYS A 1 367 ? 10.561  -20.705 -34.497 1.00 54.30  ? 630  LYS A O   1 
ATOM   2572 C  CB  . LYS A 1 367 ? 10.745  -19.232 -37.400 1.00 72.79  ? 630  LYS A CB  1 
ATOM   2573 C  CG  . LYS A 1 367 ? 12.227  -19.490 -37.136 1.00 79.73  ? 630  LYS A CG  1 
ATOM   2574 C  CD  . LYS A 1 367 ? 13.165  -18.541 -37.883 1.00 78.95  ? 630  LYS A CD  1 
ATOM   2575 C  CE  . LYS A 1 367 ? 14.322  -18.061 -37.030 1.00 80.29  ? 630  LYS A CE  1 
ATOM   2576 N  NZ  . LYS A 1 367 ? 13.916  -16.945 -36.138 1.00 81.52  ? 630  LYS A NZ  1 
ATOM   2577 N  N   . SER A 1 368 ? 9.146   -18.941 -34.579 1.00 47.79  ? 631  SER A N   1 
ATOM   2578 C  CA  . SER A 1 368 ? 9.212   -18.573 -33.137 1.00 47.12  ? 631  SER A CA  1 
ATOM   2579 C  C   . SER A 1 368 ? 7.869   -18.067 -32.594 1.00 48.35  ? 631  SER A C   1 
ATOM   2580 O  O   . SER A 1 368 ? 7.192   -17.301 -33.292 1.00 49.75  ? 631  SER A O   1 
ATOM   2581 C  CB  . SER A 1 368 ? 10.247  -17.528 -32.890 1.00 53.21  ? 631  SER A CB  1 
ATOM   2582 O  OG  . SER A 1 368 ? 10.022  -16.862 -31.649 1.00 55.62  ? 631  SER A OG  1 
ATOM   2583 N  N   . ILE A 1 369 ? 7.605   -18.379 -31.322 1.00 45.60  ? 632  ILE A N   1 
ATOM   2584 C  CA  . ILE A 1 369 ? 6.367   -18.038 -30.575 1.00 50.54  ? 632  ILE A CA  1 
ATOM   2585 C  C   . ILE A 1 369 ? 6.491   -16.608 -30.063 1.00 56.40  ? 632  ILE A C   1 
ATOM   2586 O  O   . ILE A 1 369 ? 5.486   -16.067 -29.460 1.00 46.72  ? 632  ILE A O   1 
ATOM   2587 C  CB  . ILE A 1 369 ? 6.114   -19.016 -29.407 1.00 50.25  ? 632  ILE A CB  1 
ATOM   2588 C  CG1 . ILE A 1 369 ? 7.292   -19.062 -28.443 1.00 45.39  ? 632  ILE A CG1 1 
ATOM   2589 C  CG2 . ILE A 1 369 ? 5.739   -20.407 -29.916 1.00 51.01  ? 632  ILE A CG2 1 
ATOM   2590 C  CD1 . ILE A 1 369 ? 6.963   -19.640 -27.110 1.00 47.40  ? 632  ILE A CD1 1 
ATOM   2591 N  N   . GLN A 1 370 ? 7.682   -16.030 -30.216 1.00 57.00  ? 633  GLN A N   1 
ATOM   2592 C  CA  . GLN A 1 370 ? 7.959   -14.717 -29.591 1.00 60.22  ? 633  GLN A CA  1 
ATOM   2593 C  C   . GLN A 1 370 ? 7.112   -13.689 -30.341 1.00 52.07  ? 633  GLN A C   1 
ATOM   2594 O  O   . GLN A 1 370 ? 6.512   -12.809 -29.721 1.00 43.58  ? 633  GLN A O   1 
ATOM   2595 C  CB  . GLN A 1 370 ? 9.454   -14.426 -29.587 1.00 61.10  ? 633  GLN A CB  1 
ATOM   2596 C  CG  . GLN A 1 370 ? 9.917   -13.842 -28.256 1.00 73.44  ? 633  GLN A CG  1 
ATOM   2597 C  CD  . GLN A 1 370 ? 10.039  -14.843 -27.133 1.00 72.25  ? 633  GLN A CD  1 
ATOM   2598 O  OE1 . GLN A 1 370 ? 10.204  -16.038 -27.358 1.00 80.58  ? 633  GLN A OE1 1 
ATOM   2599 N  NE2 . GLN A 1 370 ? 9.979   -14.352 -25.903 1.00 79.25  ? 633  GLN A NE2 1 
ATOM   2600 N  N   . HIS A 1 371 ? 7.009   -13.863 -31.649 1.00 51.36  ? 634  HIS A N   1 
ATOM   2601 C  CA  . HIS A 1 371 ? 6.419   -12.850 -32.531 1.00 56.86  ? 634  HIS A CA  1 
ATOM   2602 C  C   . HIS A 1 371 ? 6.161   -13.516 -33.874 1.00 57.84  ? 634  HIS A C   1 
ATOM   2603 O  O   . HIS A 1 371 ? 7.108   -14.111 -34.468 1.00 48.93  ? 634  HIS A O   1 
ATOM   2604 C  CB  . HIS A 1 371 ? 7.366   -11.632 -32.613 1.00 73.42  ? 634  HIS A CB  1 
ATOM   2605 C  CG  . HIS A 1 371 ? 7.006   -10.672 -33.693 1.00 84.58  ? 634  HIS A CG  1 
ATOM   2606 N  ND1 . HIS A 1 371 ? 5.935   -9.790  -33.571 1.00 95.34  ? 634  HIS A ND1 1 
ATOM   2607 C  CD2 . HIS A 1 371 ? 7.539   -10.470 -34.922 1.00 94.49  ? 634  HIS A CD2 1 
ATOM   2608 C  CE1 . HIS A 1 371 ? 5.840   -9.069  -34.678 1.00 109.22 ? 634  HIS A CE1 1 
ATOM   2609 N  NE2 . HIS A 1 371 ? 6.811   -9.474  -35.529 1.00 104.65 ? 634  HIS A NE2 1 
ATOM   2610 N  N   . LEU A 1 372 ? 4.917   -13.415 -34.323 1.00 57.46  ? 635  LEU A N   1 
ATOM   2611 C  CA  . LEU A 1 372 ? 4.526   -13.779 -35.698 1.00 63.64  ? 635  LEU A CA  1 
ATOM   2612 C  C   . LEU A 1 372 ? 4.746   -12.540 -36.554 1.00 63.63  ? 635  LEU A C   1 
ATOM   2613 O  O   . LEU A 1 372 ? 4.261   -11.476 -36.193 1.00 66.88  ? 635  LEU A O   1 
ATOM   2614 C  CB  . LEU A 1 372 ? 3.066   -14.251 -35.755 1.00 67.53  ? 635  LEU A CB  1 
ATOM   2615 C  CG  . LEU A 1 372 ? 2.880   -15.697 -36.198 1.00 68.49  ? 635  LEU A CG  1 
ATOM   2616 C  CD1 . LEU A 1 372 ? 3.562   -16.640 -35.218 1.00 66.55  ? 635  LEU A CD1 1 
ATOM   2617 C  CD2 . LEU A 1 372 ? 1.405   -16.031 -36.354 1.00 64.99  ? 635  LEU A CD2 1 
ATOM   2618 N  N   . THR A 1 373 ? 5.436   -12.705 -37.684 0.41 65.16  ? 636  THR A N   1 
ATOM   2619 C  CA  . THR A 1 373 ? 5.580   -11.686 -38.757 0.41 64.33  ? 636  THR A CA  1 
ATOM   2620 C  C   . THR A 1 373 ? 4.302   -11.705 -39.604 0.41 67.17  ? 636  THR A C   1 
ATOM   2621 O  O   . THR A 1 373 ? 3.629   -12.759 -39.623 0.41 65.40  ? 636  THR A O   1 
ATOM   2622 C  CB  . THR A 1 373 ? 6.838   -11.943 -39.598 0.41 63.54  ? 636  THR A CB  1 
ATOM   2623 O  OG1 . THR A 1 373 ? 6.610   -13.088 -40.419 0.41 65.12  ? 636  THR A OG1 1 
ATOM   2624 C  CG2 . THR A 1 373 ? 8.084   -12.154 -38.764 0.41 62.26  ? 636  THR A CG2 1 
ATOM   2625 N  N   . VAL A 1 374 ? 3.975   -10.595 -40.273 0.41 66.92  ? 637  VAL A N   1 
ATOM   2626 C  CA  . VAL A 1 374 ? 2.756   -10.474 -41.133 0.41 71.43  ? 637  VAL A CA  1 
ATOM   2627 C  C   . VAL A 1 374 ? 2.773   -11.591 -42.188 0.41 72.93  ? 637  VAL A C   1 
ATOM   2628 O  O   . VAL A 1 374 ? 1.684   -12.092 -42.535 0.41 72.44  ? 637  VAL A O   1 
ATOM   2629 C  CB  . VAL A 1 374 ? 2.627   -9.082  -41.787 0.41 73.54  ? 637  VAL A CB  1 
ATOM   2630 C  CG1 . VAL A 1 374 ? 2.315   -8.005  -40.759 0.41 73.84  ? 637  VAL A CG1 1 
ATOM   2631 C  CG2 . VAL A 1 374 ? 3.852   -8.704  -42.613 0.41 74.91  ? 637  VAL A CG2 1 
ATOM   2632 N  N   . THR A 1 375 ? 3.962   -11.962 -42.675 0.41 71.11  ? 638  THR A N   1 
ATOM   2633 C  CA  . THR A 1 375 ? 4.176   -13.056 -43.661 0.41 72.56  ? 638  THR A CA  1 
ATOM   2634 C  C   . THR A 1 375 ? 3.871   -14.408 -42.999 0.41 69.32  ? 638  THR A C   1 
ATOM   2635 O  O   . THR A 1 375 ? 3.243   -15.255 -43.662 0.41 63.91  ? 638  THR A O   1 
ATOM   2636 C  CB  . THR A 1 375 ? 5.599   -13.012 -44.234 0.41 76.10  ? 638  THR A CB  1 
ATOM   2637 O  OG1 . THR A 1 375 ? 6.518   -13.049 -43.142 0.41 79.11  ? 638  THR A OG1 1 
ATOM   2638 C  CG2 . THR A 1 375 ? 5.860   -11.779 -45.072 0.41 79.07  ? 638  THR A CG2 1 
ATOM   2639 N  N   . GLU A 1 376 ? 4.312   -14.604 -41.749 0.41 67.47  ? 639  GLU A N   1 
ATOM   2640 C  CA  . GLU A 1 376 ? 4.028   -15.828 -40.948 0.41 66.81  ? 639  GLU A CA  1 
ATOM   2641 C  C   . GLU A 1 376 ? 2.510   -15.953 -40.769 0.41 63.35  ? 639  GLU A C   1 
ATOM   2642 O  O   . GLU A 1 376 ? 1.993   -17.067 -40.957 0.41 62.70  ? 639  GLU A O   1 
ATOM   2643 C  CB  . GLU A 1 376 ? 4.758   -15.809 -39.599 0.41 65.46  ? 639  GLU A CB  1 
ATOM   2644 C  CG  . GLU A 1 376 ? 6.217   -16.240 -39.685 0.41 63.46  ? 639  GLU A CG  1 
ATOM   2645 C  CD  . GLU A 1 376 ? 7.026   -16.079 -38.404 0.41 63.82  ? 639  GLU A CD  1 
ATOM   2646 O  OE1 . GLU A 1 376 ? 7.848   -16.972 -38.102 0.41 63.65  ? 639  GLU A OE1 1 
ATOM   2647 O  OE2 . GLU A 1 376 ? 6.847   -15.056 -37.713 0.41 63.44  ? 639  GLU A OE2 1 
ATOM   2648 N  N   . GLU A 1 377 ? 1.825   -14.841 -40.480 0.41 62.31  ? 640  GLU A N   1 
ATOM   2649 C  CA  . GLU A 1 377 ? 0.355   -14.804 -40.236 0.41 59.74  ? 640  GLU A CA  1 
ATOM   2650 C  C   . GLU A 1 377 ? -0.398  -15.341 -41.459 0.41 59.81  ? 640  GLU A C   1 
ATOM   2651 O  O   . GLU A 1 377 ? -1.241  -16.232 -41.269 0.41 63.78  ? 640  GLU A O   1 
ATOM   2652 C  CB  . GLU A 1 377 ? -0.109  -13.392 -39.882 0.41 56.72  ? 640  GLU A CB  1 
ATOM   2653 C  CG  . GLU A 1 377 ? 0.340   -12.937 -38.505 0.41 55.71  ? 640  GLU A CG  1 
ATOM   2654 C  CD  . GLU A 1 377 ? 0.181   -11.446 -38.260 0.41 55.81  ? 640  GLU A CD  1 
ATOM   2655 O  OE1 . GLU A 1 377 ? -0.272  -10.745 -39.187 0.41 57.90  ? 640  GLU A OE1 1 
ATOM   2656 O  OE2 . GLU A 1 377 ? 0.517   -10.987 -37.147 0.41 54.19  ? 640  GLU A OE2 1 
ATOM   2657 N  N   . ILE A 1 378 ? -0.111  -14.837 -42.663 0.41 61.12  ? 641  ILE A N   1 
ATOM   2658 C  CA  . ILE A 1 378 ? -0.833  -15.248 -43.909 0.41 62.28  ? 641  ILE A CA  1 
ATOM   2659 C  C   . ILE A 1 378 ? -0.521  -16.723 -44.205 0.41 56.82  ? 641  ILE A C   1 
ATOM   2660 O  O   . ILE A 1 378 ? -1.426  -17.421 -44.698 0.41 59.46  ? 641  ILE A O   1 
ATOM   2661 C  CB  . ILE A 1 378 ? -0.514  -14.323 -45.110 0.41 64.70  ? 641  ILE A CB  1 
ATOM   2662 C  CG1 . ILE A 1 378 ? -1.494  -14.527 -46.274 0.41 67.89  ? 641  ILE A CG1 1 
ATOM   2663 C  CG2 . ILE A 1 378 ? 0.927   -14.481 -45.574 0.41 64.06  ? 641  ILE A CG2 1 
ATOM   2664 C  CD1 . ILE A 1 378 ? -2.931  -14.138 -45.971 0.41 68.34  ? 641  ILE A CD1 1 
ATOM   2665 N  N   . ALA A 1 379 ? 0.707   -17.174 -43.932 0.41 52.40  ? 642  ALA A N   1 
ATOM   2666 C  CA  . ALA A 1 379 ? 1.143   -18.581 -44.112 0.41 49.26  ? 642  ALA A CA  1 
ATOM   2667 C  C   . ALA A 1 379 ? 0.325   -19.488 -43.178 0.41 41.95  ? 642  ALA A C   1 
ATOM   2668 O  O   . ALA A 1 379 ? -0.237  -20.471 -43.673 0.41 39.38  ? 642  ALA A O   1 
ATOM   2669 C  CB  . ALA A 1 379 ? 2.628   -18.708 -43.864 0.41 49.97  ? 642  ALA A CB  1 
ATOM   2670 N  N   . VAL A 1 380 ? 0.251   -19.137 -41.890 1.00 36.04  ? 643  VAL A N   1 
ATOM   2671 C  CA  . VAL A 1 380 ? -0.633  -19.809 -40.896 1.00 44.97  ? 643  VAL A CA  1 
ATOM   2672 C  C   . VAL A 1 380 ? -2.068  -19.899 -41.449 1.00 47.47  ? 643  VAL A C   1 
ATOM   2673 O  O   . VAL A 1 380 ? -2.629  -21.024 -41.531 1.00 39.11  ? 643  VAL A O   1 
ATOM   2674 C  CB  . VAL A 1 380 ? -0.598  -19.144 -39.508 1.00 41.82  ? 643  VAL A CB  1 
ATOM   2675 C  CG1 . VAL A 1 380 ? -1.650  -19.752 -38.604 1.00 46.90  ? 643  VAL A CG1 1 
ATOM   2676 C  CG2 . VAL A 1 380 ? 0.751   -19.314 -38.822 1.00 45.65  ? 643  VAL A CG2 1 
ATOM   2677 N  N   . LYS A 1 381 ? -2.620  -18.757 -41.868 0.41 45.36  ? 644  LYS A N   1 
ATOM   2678 C  CA  . LYS A 1 381 ? -3.998  -18.652 -42.418 0.41 44.55  ? 644  LYS A CA  1 
ATOM   2679 C  C   . LYS A 1 381 ? -4.115  -19.557 -43.653 0.41 43.89  ? 644  LYS A C   1 
ATOM   2680 O  O   . LYS A 1 381 ? -5.119  -20.302 -43.741 0.41 40.50  ? 644  LYS A O   1 
ATOM   2681 C  CB  . LYS A 1 381 ? -4.334  -17.181 -42.687 0.41 47.71  ? 644  LYS A CB  1 
ATOM   2682 C  CG  . LYS A 1 381 ? -4.558  -16.363 -41.420 0.41 49.00  ? 644  LYS A CG  1 
ATOM   2683 C  CD  . LYS A 1 381 ? -4.152  -14.896 -41.480 0.41 48.82  ? 644  LYS A CD  1 
ATOM   2684 C  CE  . LYS A 1 381 ? -4.025  -14.310 -40.088 0.41 48.87  ? 644  LYS A CE  1 
ATOM   2685 N  NZ  . LYS A 1 381 ? -3.729  -12.858 -40.089 0.41 51.23  ? 644  LYS A NZ  1 
ATOM   2686 N  N   . ASN A 1 382 ? -3.112  -19.552 -44.540 0.41 40.25  ? 645  ASN A N   1 
ATOM   2687 C  CA  . ASN A 1 382 ? -3.148  -20.353 -45.795 0.41 39.80  ? 645  ASN A CA  1 
ATOM   2688 C  C   . ASN A 1 382 ? -3.037  -21.845 -45.468 0.41 39.62  ? 645  ASN A C   1 
ATOM   2689 O  O   . ASN A 1 382 ? -3.715  -22.640 -46.145 0.41 38.47  ? 645  ASN A O   1 
ATOM   2690 C  CB  . ASN A 1 382 ? -2.061  -19.978 -46.806 0.41 41.09  ? 645  ASN A CB  1 
ATOM   2691 C  CG  . ASN A 1 382 ? -2.280  -20.681 -48.131 0.41 41.38  ? 645  ASN A CG  1 
ATOM   2692 O  OD1 . ASN A 1 382 ? -3.417  -20.774 -48.601 0.41 44.73  ? 645  ASN A OD1 1 
ATOM   2693 N  ND2 . ASN A 1 382 ? -1.220  -21.198 -48.730 0.41 39.75  ? 645  ASN A ND2 1 
ATOM   2694 N  N   . TRP A 1 383 ? -2.206  -22.208 -44.481 1.00 41.56  ? 646  TRP A N   1 
ATOM   2695 C  CA  . TRP A 1 383 ? -2.055  -23.634 -44.046 1.00 40.44  ? 646  TRP A CA  1 
ATOM   2696 C  C   . TRP A 1 383 ? -3.450  -24.172 -43.629 1.00 30.72  ? 646  TRP A C   1 
ATOM   2697 O  O   . TRP A 1 383 ? -3.962  -25.159 -44.252 1.00 33.13  ? 646  TRP A O   1 
ATOM   2698 C  CB  . TRP A 1 383 ? -1.001  -23.695 -42.940 1.00 34.56  ? 646  TRP A CB  1 
ATOM   2699 C  CG  . TRP A 1 383 ? -0.622  -25.064 -42.462 1.00 42.02  ? 646  TRP A CG  1 
ATOM   2700 C  CD1 . TRP A 1 383 ? 0.410   -25.846 -42.898 1.00 43.85  ? 646  TRP A CD1 1 
ATOM   2701 C  CD2 . TRP A 1 383 ? -1.245  -25.802 -41.395 1.00 37.77  ? 646  TRP A CD2 1 
ATOM   2702 N  NE1 . TRP A 1 383 ? 0.498   -27.003 -42.167 1.00 38.77  ? 646  TRP A NE1 1 
ATOM   2703 C  CE2 . TRP A 1 383 ? -0.490  -26.993 -41.220 1.00 40.69  ? 646  TRP A CE2 1 
ATOM   2704 C  CE3 . TRP A 1 383 ? -2.317  -25.549 -40.532 1.00 34.32  ? 646  TRP A CE3 1 
ATOM   2705 C  CZ2 . TRP A 1 383 ? -0.802  -27.930 -40.230 1.00 33.85  ? 646  TRP A CZ2 1 
ATOM   2706 C  CZ3 . TRP A 1 383 ? -2.618  -26.471 -39.543 1.00 36.93  ? 646  TRP A CZ3 1 
ATOM   2707 C  CH2 . TRP A 1 383 ? -1.883  -27.659 -39.412 1.00 35.91  ? 646  TRP A CH2 1 
ATOM   2708 N  N   . LEU A 1 384 ? -4.128  -23.402 -42.791 1.00 35.88  ? 647  LEU A N   1 
ATOM   2709 C  CA  . LEU A 1 384 ? -5.495  -23.743 -42.303 1.00 40.23  ? 647  LEU A CA  1 
ATOM   2710 C  C   . LEU A 1 384 ? -6.460  -23.986 -43.480 1.00 41.30  ? 647  LEU A C   1 
ATOM   2711 O  O   . LEU A 1 384 ? -7.112  -25.064 -43.547 1.00 37.95  ? 647  LEU A O   1 
ATOM   2712 C  CB  . LEU A 1 384 ? -5.943  -22.663 -41.316 1.00 33.83  ? 647  LEU A CB  1 
ATOM   2713 C  CG  . LEU A 1 384 ? -5.253  -22.735 -39.964 1.00 35.46  ? 647  LEU A CG  1 
ATOM   2714 C  CD1 . LEU A 1 384 ? -5.587  -21.552 -39.098 1.00 38.35  ? 647  LEU A CD1 1 
ATOM   2715 C  CD2 . LEU A 1 384 ? -5.562  -24.023 -39.209 1.00 40.26  ? 647  LEU A CD2 1 
ATOM   2716 N  N   . VAL A 1 385 ? -6.557  -23.022 -44.397 0.41 42.25  ? 648  VAL A N   1 
ATOM   2717 C  CA  . VAL A 1 385 ? -7.531  -23.066 -45.526 0.41 41.93  ? 648  VAL A CA  1 
ATOM   2718 C  C   . VAL A 1 385 ? -7.117  -24.192 -46.477 0.41 41.99  ? 648  VAL A C   1 
ATOM   2719 O  O   . VAL A 1 385 ? -8.014  -24.901 -46.960 0.41 47.53  ? 648  VAL A O   1 
ATOM   2720 C  CB  . VAL A 1 385 ? -7.660  -21.703 -46.240 0.41 44.59  ? 648  VAL A CB  1 
ATOM   2721 C  CG1 . VAL A 1 385 ? -8.633  -21.767 -47.406 0.41 43.06  ? 648  VAL A CG1 1 
ATOM   2722 C  CG2 . VAL A 1 385 ? -8.074  -20.594 -45.278 0.41 45.32  ? 648  VAL A CG2 1 
ATOM   2723 N  N   . ARG A 1 386 ? -5.813  -24.388 -46.697 0.41 42.38  ? 649  ARG A N   1 
ATOM   2724 C  CA  . ARG A 1 386 ? -5.282  -25.433 -47.615 0.41 44.24  ? 649  ARG A CA  1 
ATOM   2725 C  C   . ARG A 1 386 ? -5.421  -26.827 -46.977 0.41 42.65  ? 649  ARG A C   1 
ATOM   2726 O  O   . ARG A 1 386 ? -6.044  -27.687 -47.620 0.41 44.22  ? 649  ARG A O   1 
ATOM   2727 C  CB  . ARG A 1 386 ? -3.828  -25.125 -48.000 0.41 50.61  ? 649  ARG A CB  1 
ATOM   2728 C  CG  . ARG A 1 386 ? -3.226  -26.074 -49.032 0.41 55.87  ? 649  ARG A CG  1 
ATOM   2729 C  CD  . ARG A 1 386 ? -1.845  -25.668 -49.551 0.41 61.27  ? 649  ARG A CD  1 
ATOM   2730 N  NE  . ARG A 1 386 ? -0.745  -25.906 -48.612 0.41 62.81  ? 649  ARG A NE  1 
ATOM   2731 C  CZ  . ARG A 1 386 ? -0.289  -25.033 -47.705 0.41 61.90  ? 649  ARG A CZ  1 
ATOM   2732 N  NH1 . ARG A 1 386 ? -0.830  -23.830 -47.586 0.41 63.92  ? 649  ARG A NH1 1 
ATOM   2733 N  NH2 . ARG A 1 386 ? 0.715   -25.372 -46.914 0.41 56.17  ? 649  ARG A NH2 1 
ATOM   2734 N  N   . VAL A 1 387 ? -4.859  -27.061 -45.782 0.41 38.72  ? 650  VAL A N   1 
ATOM   2735 C  CA  . VAL A 1 387 ? -4.659  -28.446 -45.241 0.41 38.77  ? 650  VAL A CA  1 
ATOM   2736 C  C   . VAL A 1 387 ? -5.401  -28.666 -43.908 0.41 37.14  ? 650  VAL A C   1 
ATOM   2737 O  O   . VAL A 1 387 ? -5.415  -29.838 -43.462 0.41 34.88  ? 650  VAL A O   1 
ATOM   2738 C  CB  . VAL A 1 387 ? -3.159  -28.781 -45.090 0.41 36.58  ? 650  VAL A CB  1 
ATOM   2739 C  CG1 . VAL A 1 387 ? -2.418  -28.592 -46.402 0.41 37.90  ? 650  VAL A CG1 1 
ATOM   2740 C  CG2 . VAL A 1 387 ? -2.487  -27.992 -43.972 0.41 35.04  ? 650  VAL A CG2 1 
ATOM   2741 N  N   . GLY A 1 388 ? -5.972  -27.613 -43.307 1.00 34.68  ? 651  GLY A N   1 
ATOM   2742 C  CA  . GLY A 1 388 ? -6.580  -27.650 -41.951 1.00 34.69  ? 651  GLY A CA  1 
ATOM   2743 C  C   . GLY A 1 388 ? -7.499  -28.858 -41.734 1.00 34.71  ? 651  GLY A C   1 
ATOM   2744 O  O   . GLY A 1 388 ? -7.372  -29.541 -40.746 1.00 32.58  ? 651  GLY A O   1 
ATOM   2745 N  N   . ARG A 1 389 ? -8.396  -29.114 -42.683 0.41 35.73  ? 652  ARG A N   1 
ATOM   2746 C  CA  . ARG A 1 389 ? -9.394  -30.211 -42.585 0.41 37.69  ? 652  ARG A CA  1 
ATOM   2747 C  C   . ARG A 1 389 ? -8.662  -31.560 -42.579 0.41 36.16  ? 652  ARG A C   1 
ATOM   2748 O  O   . ARG A 1 389 ? -9.056  -32.426 -41.776 0.41 36.39  ? 652  ARG A O   1 
ATOM   2749 C  CB  . ARG A 1 389 ? -10.426 -30.110 -43.714 0.41 38.34  ? 652  ARG A CB  1 
ATOM   2750 C  CG  . ARG A 1 389 ? -11.381 -28.934 -43.565 0.41 40.25  ? 652  ARG A CG  1 
ATOM   2751 C  CD  . ARG A 1 389 ? -12.441 -28.923 -44.654 0.41 40.89  ? 652  ARG A CD  1 
ATOM   2752 N  NE  . ARG A 1 389 ? -13.337 -30.070 -44.579 0.41 39.43  ? 652  ARG A NE  1 
ATOM   2753 C  CZ  . ARG A 1 389 ? -14.397 -30.166 -43.771 0.41 40.51  ? 652  ARG A CZ  1 
ATOM   2754 N  NH1 . ARG A 1 389 ? -14.719 -29.177 -42.947 0.41 40.39  ? 652  ARG A NH1 1 
ATOM   2755 N  NH2 . ARG A 1 389 ? -15.130 -31.266 -43.785 0.41 39.03  ? 652  ARG A NH2 1 
ATOM   2756 N  N   . GLU A 1 390 ? -7.636  -31.738 -43.419 0.41 34.16  ? 653  GLU A N   1 
ATOM   2757 C  CA  . GLU A 1 390 ? -6.851  -33.010 -43.473 0.41 34.72  ? 653  GLU A CA  1 
ATOM   2758 C  C   . GLU A 1 390 ? -6.150  -33.213 -42.122 0.41 31.82  ? 653  GLU A C   1 
ATOM   2759 O  O   . GLU A 1 390 ? -6.158  -34.360 -41.620 0.41 31.25  ? 653  GLU A O   1 
ATOM   2760 C  CB  . GLU A 1 390 ? -5.833  -33.023 -44.619 0.41 34.80  ? 653  GLU A CB  1 
ATOM   2761 C  CG  . GLU A 1 390 ? -5.436  -34.423 -45.071 0.41 35.49  ? 653  GLU A CG  1 
ATOM   2762 C  CD  . GLU A 1 390 ? -4.481  -35.199 -44.170 0.41 37.34  ? 653  GLU A CD  1 
ATOM   2763 O  OE1 . GLU A 1 390 ? -3.545  -34.588 -43.609 0.41 36.70  ? 653  GLU A OE1 1 
ATOM   2764 O  OE2 . GLU A 1 390 ? -4.670  -36.427 -44.032 0.41 40.71  ? 653  GLU A OE2 1 
ATOM   2765 N  N   . ARG A 1 391 ? -5.615  -32.136 -41.542 0.41 31.91  ? 654  ARG A N   1 
ATOM   2766 C  CA  . ARG A 1 391 ? -4.863  -32.174 -40.261 0.41 33.49  ? 654  ARG A CA  1 
ATOM   2767 C  C   . ARG A 1 391 ? -5.826  -32.536 -39.114 0.41 31.35  ? 654  ARG A C   1 
ATOM   2768 O  O   . ARG A 1 391 ? -5.460  -33.410 -38.288 0.41 27.33  ? 654  ARG A O   1 
ATOM   2769 C  CB  . ARG A 1 391 ? -4.110  -30.856 -40.053 0.41 35.20  ? 654  ARG A CB  1 
ATOM   2770 C  CG  . ARG A 1 391 ? -3.079  -30.545 -41.134 0.41 36.66  ? 654  ARG A CG  1 
ATOM   2771 C  CD  . ARG A 1 391 ? -2.005  -31.607 -41.312 0.41 39.29  ? 654  ARG A CD  1 
ATOM   2772 N  NE  . ARG A 1 391 ? -0.916  -31.065 -42.115 0.41 42.27  ? 654  ARG A NE  1 
ATOM   2773 C  CZ  . ARG A 1 391 ? -0.725  -31.289 -43.414 0.41 42.74  ? 654  ARG A CZ  1 
ATOM   2774 N  NH1 . ARG A 1 391 ? -1.516  -32.097 -44.102 0.41 44.32  ? 654  ARG A NH1 1 
ATOM   2775 N  NH2 . ARG A 1 391 ? 0.281   -30.699 -44.030 0.41 46.23  ? 654  ARG A NH2 1 
ATOM   2776 N  N   . LEU A 1 392 ? -7.021  -31.931 -39.072 0.41 30.85  ? 655  LEU A N   1 
ATOM   2777 C  CA  . LEU A 1 392 ? -8.062  -32.252 -38.054 0.41 30.53  ? 655  LEU A CA  1 
ATOM   2778 C  C   . LEU A 1 392 ? -8.417  -33.742 -38.150 0.41 31.83  ? 655  LEU A C   1 
ATOM   2779 O  O   . LEU A 1 392 ? -8.659  -34.365 -37.085 0.41 33.00  ? 655  LEU A O   1 
ATOM   2780 C  CB  . LEU A 1 392 ? -9.303  -31.376 -38.264 0.41 30.75  ? 655  LEU A CB  1 
ATOM   2781 C  CG  . LEU A 1 392 ? -9.171  -29.919 -37.835 0.41 31.10  ? 655  LEU A CG  1 
ATOM   2782 C  CD1 . LEU A 1 392 ? -10.406 -29.128 -38.242 0.41 33.24  ? 655  LEU A CD1 1 
ATOM   2783 C  CD2 . LEU A 1 392 ? -8.935  -29.801 -36.337 0.41 31.12  ? 655  LEU A CD2 1 
ATOM   2784 N  N   . SER A 1 393 ? -8.416  -34.297 -39.366 0.41 30.81  ? 656  SER A N   1 
ATOM   2785 C  CA  . SER A 1 393 ? -8.750  -35.716 -39.647 0.41 31.46  ? 656  SER A CA  1 
ATOM   2786 C  C   . SER A 1 393 ? -7.700  -36.661 -39.053 0.41 31.47  ? 656  SER A C   1 
ATOM   2787 O  O   . SER A 1 393 ? -8.051  -37.816 -38.821 0.41 29.90  ? 656  SER A O   1 
ATOM   2788 C  CB  . SER A 1 393 ? -8.927  -35.958 -41.124 0.41 33.39  ? 656  SER A CB  1 
ATOM   2789 O  OG  . SER A 1 393 ? -7.774  -35.553 -41.851 0.41 34.38  ? 656  SER A OG  1 
ATOM   2790 N  N   . ARG A 1 394 ? -6.460  -36.192 -38.841 0.41 30.88  ? 657  ARG A N   1 
ATOM   2791 C  CA  . ARG A 1 394 ? -5.319  -37.012 -38.348 0.41 30.81  ? 657  ARG A CA  1 
ATOM   2792 C  C   . ARG A 1 394 ? -5.401  -37.165 -36.828 0.41 28.81  ? 657  ARG A C   1 
ATOM   2793 O  O   . ARG A 1 394 ? -4.449  -37.717 -36.245 0.41 26.86  ? 657  ARG A O   1 
ATOM   2794 C  CB  . ARG A 1 394 ? -3.977  -36.357 -38.698 0.41 32.06  ? 657  ARG A CB  1 
ATOM   2795 C  CG  . ARG A 1 394 ? -3.673  -36.311 -40.185 0.41 33.12  ? 657  ARG A CG  1 
ATOM   2796 C  CD  . ARG A 1 394 ? -2.412  -35.523 -40.499 0.41 35.06  ? 657  ARG A CD  1 
ATOM   2797 N  NE  . ARG A 1 394 ? -1.979  -35.916 -41.825 0.41 36.01  ? 657  ARG A NE  1 
ATOM   2798 C  CZ  . ARG A 1 394 ? -1.253  -36.990 -42.099 0.41 38.29  ? 657  ARG A CZ  1 
ATOM   2799 N  NH1 . ARG A 1 394 ? -0.797  -37.765 -41.127 0.41 38.69  ? 657  ARG A NH1 1 
ATOM   2800 N  NH2 . ARG A 1 394 ? -0.967  -37.279 -43.356 0.41 39.90  ? 657  ARG A NH2 1 
ATOM   2801 N  N   . MET A 1 395 ? -6.486  -36.697 -36.207 0.41 26.85  ? 658  MET A N   1 
ATOM   2802 C  CA  . MET A 1 395 ? -6.620  -36.659 -34.729 0.41 26.39  ? 658  MET A CA  1 
ATOM   2803 C  C   . MET A 1 395 ? -7.938  -37.300 -34.267 0.41 25.46  ? 658  MET A C   1 
ATOM   2804 O  O   . MET A 1 395 ? -8.913  -37.351 -35.044 0.41 23.85  ? 658  MET A O   1 
ATOM   2805 C  CB  . MET A 1 395 ? -6.511  -35.210 -34.246 0.41 26.84  ? 658  MET A CB  1 
ATOM   2806 C  CG  . MET A 1 395 ? -5.253  -34.515 -34.764 0.41 27.88  ? 658  MET A CG  1 
ATOM   2807 S  SD  . MET A 1 395 ? -4.924  -32.926 -33.973 0.41 28.71  ? 658  MET A SD  1 
ATOM   2808 C  CE  . MET A 1 395 ? -6.206  -31.911 -34.712 0.41 28.49  ? 658  MET A CE  1 
ATOM   2809 N  N   . ALA A 1 396 ? -7.932  -37.816 -33.036 1.00 24.20  ? 659  ALA A N   1 
ATOM   2810 C  CA  . ALA A 1 396 ? -9.142  -38.213 -32.296 1.00 22.57  ? 659  ALA A CA  1 
ATOM   2811 C  C   . ALA A 1 396 ? -9.039  -37.533 -30.926 1.00 23.34  ? 659  ALA A C   1 
ATOM   2812 O  O   . ALA A 1 396 ? -8.040  -37.700 -30.248 1.00 22.27  ? 659  ALA A O   1 
ATOM   2813 C  CB  . ALA A 1 396 ? -9.247  -39.701 -32.227 1.00 24.28  ? 659  ALA A CB  1 
ATOM   2814 N  N   . ILE A 1 397 ? -9.942  -36.598 -30.670 1.00 23.37  ? 660  ILE A N   1 
ATOM   2815 C  CA  . ILE A 1 397 ? -9.936  -35.709 -29.502 1.00 22.54  ? 660  ILE A CA  1 
ATOM   2816 C  C   . ILE A 1 397 ? -11.285 -35.818 -28.763 1.00 27.28  ? 660  ILE A C   1 
ATOM   2817 O  O   . ILE A 1 397 ? -12.342 -35.559 -29.323 1.00 25.03  ? 660  ILE A O   1 
ATOM   2818 C  CB  . ILE A 1 397 ? -9.602  -34.301 -29.965 1.00 25.47  ? 660  ILE A CB  1 
ATOM   2819 C  CG1 . ILE A 1 397 ? -8.265  -34.295 -30.716 1.00 28.64  ? 660  ILE A CG1 1 
ATOM   2820 C  CG2 . ILE A 1 397 ? -9.648  -33.395 -28.750 1.00 25.48  ? 660  ILE A CG2 1 
ATOM   2821 C  CD1 . ILE A 1 397 ? -7.680  -32.940 -31.108 1.00 30.44  ? 660  ILE A CD1 1 
ATOM   2822 N  N   . SER A 1 398 ? -11.181 -36.123 -27.496 1.00 25.14  ? 661  SER A N   1 
ATOM   2823 C  CA  . SER A 1 398 ? -12.266 -36.296 -26.535 1.00 26.95  ? 661  SER A CA  1 
ATOM   2824 C  C   . SER A 1 398 ? -11.940 -35.440 -25.324 1.00 26.05  ? 661  SER A C   1 
ATOM   2825 O  O   . SER A 1 398 ? -11.206 -35.903 -24.467 1.00 26.81  ? 661  SER A O   1 
ATOM   2826 C  CB  . SER A 1 398 ? -12.428 -37.718 -26.170 1.00 28.07  ? 661  SER A CB  1 
ATOM   2827 O  OG  . SER A 1 398 ? -13.674 -37.869 -25.535 1.00 29.19  ? 661  SER A OG  1 
ATOM   2828 N  N   . GLY A 1 399 ? -12.459 -34.213 -25.297 1.00 26.18  ? 662  GLY A N   1 
ATOM   2829 C  CA  . GLY A 1 399 ? -12.090 -33.253 -24.244 1.00 27.55  ? 662  GLY A CA  1 
ATOM   2830 C  C   . GLY A 1 399 ? -10.584 -33.105 -24.136 1.00 28.65  ? 662  GLY A C   1 
ATOM   2831 O  O   . GLY A 1 399 ? -9.966  -32.792 -25.145 1.00 28.18  ? 662  GLY A O   1 
ATOM   2832 N  N   . ASP A 1 400 ? -10.011 -33.347 -22.962 1.00 27.55  ? 663  ASP A N   1 
ATOM   2833 C  CA  . ASP A 1 400 ? -8.543  -33.180 -22.750 1.00 29.20  ? 663  ASP A CA  1 
ATOM   2834 C  C   . ASP A 1 400 ? -7.744  -34.358 -23.321 1.00 29.60  ? 663  ASP A C   1 
ATOM   2835 O  O   . ASP A 1 400 ? -6.522  -34.292 -23.312 1.00 28.36  ? 663  ASP A O   1 
ATOM   2836 C  CB  . ASP A 1 400 ? -8.221  -32.952 -21.282 1.00 33.32  ? 663  ASP A CB  1 
ATOM   2837 C  CG  . ASP A 1 400 ? -8.580  -34.093 -20.342 1.00 38.28  ? 663  ASP A CG  1 
ATOM   2838 O  OD1 . ASP A 1 400 ? -9.201  -35.059 -20.762 1.00 42.81  ? 663  ASP A OD1 1 
ATOM   2839 O  OD2 . ASP A 1 400 ? -8.177  -34.014 -19.185 1.00 48.63  ? 663  ASP A OD2 1 
ATOM   2840 N  N   . ASP A 1 401 ? -8.383  -35.351 -23.894 1.00 27.84  ? 664  ASP A N   1 
ATOM   2841 C  CA  . ASP A 1 401 ? -7.725  -36.613 -24.332 1.00 29.33  ? 664  ASP A CA  1 
ATOM   2842 C  C   . ASP A 1 401 ? -7.487  -36.534 -25.831 1.00 29.22  ? 664  ASP A C   1 
ATOM   2843 O  O   . ASP A 1 401 ? -8.458  -36.167 -26.533 1.00 29.87  ? 664  ASP A O   1 
ATOM   2844 C  CB  . ASP A 1 401 ? -8.588  -37.816 -23.931 1.00 30.48  ? 664  ASP A CB  1 
ATOM   2845 C  CG  . ASP A 1 401 ? -7.769  -39.087 -23.825 1.00 41.54  ? 664  ASP A CG  1 
ATOM   2846 O  OD1 . ASP A 1 401 ? -6.623  -38.976 -24.158 1.00 37.60  ? 664  ASP A OD1 1 
ATOM   2847 O  OD2 . ASP A 1 401 ? -8.278  -40.145 -23.453 1.00 41.24  ? 664  ASP A OD2 1 
ATOM   2848 N  N   . CYS A 1 402 ? -6.249  -36.729 -26.319 1.00 25.24  ? 665  CYS A N   1 
ATOM   2849 C  CA  . CYS A 1 402 ? -5.980  -36.748 -27.775 1.00 24.29  ? 665  CYS A CA  1 
ATOM   2850 C  C   . CYS A 1 402 ? -5.109  -37.915 -28.200 1.00 24.57  ? 665  CYS A C   1 
ATOM   2851 O  O   . CYS A 1 402 ? -4.241  -38.376 -27.442 1.00 25.66  ? 665  CYS A O   1 
ATOM   2852 C  CB  . CYS A 1 402 ? -5.360  -35.464 -28.287 1.00 30.45  ? 665  CYS A CB  1 
ATOM   2853 S  SG  . CYS A 1 402 ? -3.810  -35.059 -27.455 1.00 36.61  ? 665  CYS A SG  1 
ATOM   2854 N  N   . VAL A 1 403 ? -5.284  -38.236 -29.463 1.00 22.25  ? 666  VAL A N   1 
ATOM   2855 C  CA  . VAL A 1 403 ? -4.408  -39.074 -30.315 1.00 25.29  ? 666  VAL A CA  1 
ATOM   2856 C  C   . VAL A 1 403 ? -4.194  -38.258 -31.588 1.00 24.69  ? 666  VAL A C   1 
ATOM   2857 O  O   . VAL A 1 403 ? -5.169  -37.757 -32.148 1.00 23.86  ? 666  VAL A O   1 
ATOM   2858 C  CB  . VAL A 1 403 ? -5.022  -40.457 -30.583 1.00 24.28  ? 666  VAL A CB  1 
ATOM   2859 C  CG1 . VAL A 1 403 ? -4.166  -41.324 -31.480 1.00 26.78  ? 666  VAL A CG1 1 
ATOM   2860 C  CG2 . VAL A 1 403 ? -5.333  -41.155 -29.237 1.00 26.82  ? 666  VAL A CG2 1 
ATOM   2861 N  N   . VAL A 1 404 ? -2.935  -38.076 -31.972 1.00 21.89  ? 667  VAL A N   1 
ATOM   2862 C  CA  . VAL A 1 404 ? -2.507  -37.314 -33.181 1.00 23.14  ? 667  VAL A CA  1 
ATOM   2863 C  C   . VAL A 1 404 ? -1.554  -38.182 -33.976 1.00 24.30  ? 667  VAL A C   1 
ATOM   2864 O  O   . VAL A 1 404 ? -0.573  -38.669 -33.399 1.00 25.15  ? 667  VAL A O   1 
ATOM   2865 C  CB  . VAL A 1 404 ? -1.808  -35.990 -32.804 1.00 24.24  ? 667  VAL A CB  1 
ATOM   2866 C  CG1 . VAL A 1 404 ? -1.371  -35.209 -34.053 1.00 27.22  ? 667  VAL A CG1 1 
ATOM   2867 C  CG2 . VAL A 1 404 ? -2.654  -35.110 -31.884 1.00 25.55  ? 667  VAL A CG2 1 
ATOM   2868 N  N   . LYS A 1 405 ? -1.831  -38.376 -35.270 0.41 24.87  ? 668  LYS A N   1 
ATOM   2869 C  CA  . LYS A 1 405 ? -0.885  -38.969 -36.254 0.41 24.59  ? 668  LYS A CA  1 
ATOM   2870 C  C   . LYS A 1 405 ? -0.388  -37.847 -37.165 0.41 25.75  ? 668  LYS A C   1 
ATOM   2871 O  O   . LYS A 1 405 ? -0.978  -37.580 -38.211 0.41 25.30  ? 668  LYS A O   1 
ATOM   2872 C  CB  . LYS A 1 405 ? -1.499  -40.096 -37.084 0.41 24.64  ? 668  LYS A CB  1 
ATOM   2873 C  CG  . LYS A 1 405 ? -0.561  -40.643 -38.160 0.41 25.71  ? 668  LYS A CG  1 
ATOM   2874 C  CD  . LYS A 1 405 ? -0.615  -42.147 -38.375 0.41 26.76  ? 668  LYS A CD  1 
ATOM   2875 C  CE  . LYS A 1 405 ? 0.602   -42.661 -39.126 0.41 27.53  ? 668  LYS A CE  1 
ATOM   2876 N  NZ  . LYS A 1 405 ? 0.667   -44.141 -39.145 0.41 27.31  ? 668  LYS A NZ  1 
ATOM   2877 N  N   . PRO A 1 406 ? 0.707   -37.148 -36.796 1.00 26.05  ? 669  PRO A N   1 
ATOM   2878 C  CA  . PRO A 1 406 ? 1.200   -36.024 -37.603 1.00 27.35  ? 669  PRO A CA  1 
ATOM   2879 C  C   . PRO A 1 406 ? 1.861   -36.469 -38.898 1.00 24.99  ? 669  PRO A C   1 
ATOM   2880 O  O   . PRO A 1 406 ? 2.096   -37.667 -39.164 1.00 26.42  ? 669  PRO A O   1 
ATOM   2881 C  CB  . PRO A 1 406 ? 2.170   -35.339 -36.632 1.00 25.52  ? 669  PRO A CB  1 
ATOM   2882 C  CG  . PRO A 1 406 ? 2.730   -36.495 -35.863 1.00 26.79  ? 669  PRO A CG  1 
ATOM   2883 C  CD  . PRO A 1 406 ? 1.533   -37.405 -35.615 1.00 26.15  ? 669  PRO A CD  1 
ATOM   2884 N  N   . LEU A 1 407 ? 2.174   -35.480 -39.721 1.00 30.99  ? 670  LEU A N   1 
ATOM   2885 C  CA  . LEU A 1 407 ? 2.813   -35.696 -41.057 1.00 32.85  ? 670  LEU A CA  1 
ATOM   2886 C  C   . LEU A 1 407 ? 4.144   -36.457 -40.866 1.00 29.54  ? 670  LEU A C   1 
ATOM   2887 O  O   . LEU A 1 407 ? 4.465   -37.282 -41.712 1.00 32.17  ? 670  LEU A O   1 
ATOM   2888 C  CB  . LEU A 1 407 ? 2.995   -34.316 -41.700 1.00 35.28  ? 670  LEU A CB  1 
ATOM   2889 C  CG  . LEU A 1 407 ? 3.040   -34.259 -43.217 1.00 47.21  ? 670  LEU A CG  1 
ATOM   2890 C  CD1 . LEU A 1 407 ? 1.706   -34.646 -43.850 1.00 46.68  ? 670  LEU A CD1 1 
ATOM   2891 C  CD2 . LEU A 1 407 ? 3.428   -32.846 -43.642 1.00 51.06  ? 670  LEU A CD2 1 
ATOM   2892 N  N   . ASP A 1 408 ? 4.859   -36.240 -39.769 1.00 28.96  ? 671  ASP A N   1 
ATOM   2893 C  CA  . ASP A 1 408 ? 6.176   -36.902 -39.517 1.00 32.54  ? 671  ASP A CA  1 
ATOM   2894 C  C   . ASP A 1 408 ? 6.544   -36.719 -38.057 1.00 28.95  ? 671  ASP A C   1 
ATOM   2895 O  O   . ASP A 1 408 ? 5.828   -36.018 -37.321 1.00 32.92  ? 671  ASP A O   1 
ATOM   2896 C  CB  . ASP A 1 408 ? 7.294   -36.381 -40.457 1.00 32.24  ? 671  ASP A CB  1 
ATOM   2897 C  CG  . ASP A 1 408 ? 7.303   -34.866 -40.533 1.00 31.30  ? 671  ASP A CG  1 
ATOM   2898 O  OD1 . ASP A 1 408 ? 7.574   -34.233 -39.460 1.00 31.69  ? 671  ASP A OD1 1 
ATOM   2899 O  OD2 . ASP A 1 408 ? 6.948   -34.310 -41.622 1.00 36.37  ? 671  ASP A OD2 1 
ATOM   2900 N  N   . ASP A 1 409 ? 7.684   -37.247 -37.657 1.00 27.55  ? 672  ASP A N   1 
ATOM   2901 C  CA  . ASP A 1 409 ? 8.055   -37.228 -36.220 1.00 27.20  ? 672  ASP A CA  1 
ATOM   2902 C  C   . ASP A 1 409 ? 8.703   -35.914 -35.785 1.00 27.03  ? 672  ASP A C   1 
ATOM   2903 O  O   . ASP A 1 409 ? 9.033   -35.816 -34.598 1.00 26.84  ? 672  ASP A O   1 
ATOM   2904 C  CB  . ASP A 1 409 ? 8.817   -38.502 -35.876 1.00 29.54  ? 672  ASP A CB  1 
ATOM   2905 C  CG  . ASP A 1 409 ? 7.924   -39.724 -36.038 1.00 34.78  ? 672  ASP A CG  1 
ATOM   2906 O  OD1 . ASP A 1 409 ? 6.753   -39.677 -35.536 1.00 34.13  ? 672  ASP A OD1 1 
ATOM   2907 O  OD2 . ASP A 1 409 ? 8.361   -40.683 -36.701 1.00 37.63  ? 672  ASP A OD2 1 
ATOM   2908 N  N   . ARG A 1 410 ? 8.736   -34.862 -36.598 1.00 27.84  ? 673  ARG A N   1 
ATOM   2909 C  CA  . ARG A 1 410 ? 9.213   -33.547 -36.067 1.00 32.43  ? 673  ARG A CA  1 
ATOM   2910 C  C   . ARG A 1 410 ? 8.299   -33.069 -34.949 1.00 32.37  ? 673  ARG A C   1 
ATOM   2911 O  O   . ARG A 1 410 ? 8.765   -32.353 -34.089 1.00 28.52  ? 673  ARG A O   1 
ATOM   2912 C  CB  . ARG A 1 410 ? 9.289   -32.472 -37.161 1.00 37.96  ? 673  ARG A CB  1 
ATOM   2913 C  CG  . ARG A 1 410 ? 10.373  -32.685 -38.207 1.00 36.91  ? 673  ARG A CG  1 
ATOM   2914 C  CD  . ARG A 1 410 ? 10.222  -31.621 -39.298 1.00 37.10  ? 673  ARG A CD  1 
ATOM   2915 N  NE  . ARG A 1 410 ? 9.050   -31.895 -40.124 1.00 34.79  ? 673  ARG A NE  1 
ATOM   2916 C  CZ  . ARG A 1 410 ? 8.541   -31.101 -41.065 1.00 40.70  ? 673  ARG A CZ  1 
ATOM   2917 N  NH1 . ARG A 1 410 ? 9.115   -29.926 -41.343 1.00 34.63  ? 673  ARG A NH1 1 
ATOM   2918 N  NH2 . ARG A 1 410 ? 7.486   -31.533 -41.764 1.00 38.27  ? 673  ARG A NH2 1 
ATOM   2919 N  N   . PHE A 1 411 ? 6.984   -33.408 -35.010 1.00 29.55  ? 674  PHE A N   1 
ATOM   2920 C  CA  . PHE A 1 411 ? 5.972   -33.195 -33.961 1.00 23.36  ? 674  PHE A CA  1 
ATOM   2921 C  C   . PHE A 1 411 ? 6.489   -33.544 -32.586 1.00 23.64  ? 674  PHE A C   1 
ATOM   2922 O  O   . PHE A 1 411 ? 6.208   -32.790 -31.635 1.00 25.96  ? 674  PHE A O   1 
ATOM   2923 C  CB  . PHE A 1 411 ? 4.739   -34.066 -34.265 1.00 27.43  ? 674  PHE A CB  1 
ATOM   2924 C  CG  . PHE A 1 411 ? 3.536   -33.845 -33.387 1.00 27.00  ? 674  PHE A CG  1 
ATOM   2925 C  CD1 . PHE A 1 411 ? 3.336   -34.620 -32.254 1.00 28.06  ? 674  PHE A CD1 1 
ATOM   2926 C  CD2 . PHE A 1 411 ? 2.557   -32.943 -33.748 1.00 26.52  ? 674  PHE A CD2 1 
ATOM   2927 C  CE1 . PHE A 1 411 ? 2.189   -34.466 -31.481 1.00 28.33  ? 674  PHE A CE1 1 
ATOM   2928 C  CE2 . PHE A 1 411 ? 1.410   -32.773 -32.975 1.00 25.35  ? 674  PHE A CE2 1 
ATOM   2929 C  CZ  . PHE A 1 411 ? 1.249   -33.500 -31.805 1.00 27.70  ? 674  PHE A CZ  1 
ATOM   2930 N  N   . ALA A 1 412 ? 7.221   -34.660 -32.438 1.00 25.49  ? 675  ALA A N   1 
ATOM   2931 C  CA  . ALA A 1 412 ? 7.677   -35.160 -31.128 1.00 26.46  ? 675  ALA A CA  1 
ATOM   2932 C  C   . ALA A 1 412 ? 8.453   -34.103 -30.327 1.00 31.09  ? 675  ALA A C   1 
ATOM   2933 O  O   . ALA A 1 412 ? 8.344   -34.054 -29.077 1.00 25.77  ? 675  ALA A O   1 
ATOM   2934 C  CB  . ALA A 1 412 ? 8.507   -36.407 -31.334 1.00 28.44  ? 675  ALA A CB  1 
ATOM   2935 N  N   . SER A 1 413 ? 9.222   -33.253 -30.989 1.00 31.63  ? 676  SER A N   1 
ATOM   2936 C  CA  . SER A 1 413 ? 10.067  -32.249 -30.294 1.00 33.63  ? 676  SER A CA  1 
ATOM   2937 C  C   . SER A 1 413 ? 9.566   -30.833 -30.580 1.00 38.96  ? 676  SER A C   1 
ATOM   2938 O  O   . SER A 1 413 ? 10.255  -29.894 -30.190 1.00 38.54  ? 676  SER A O   1 
ATOM   2939 C  CB  . SER A 1 413 ? 11.570  -32.422 -30.670 1.00 37.35  ? 676  SER A CB  1 
ATOM   2940 O  OG  . SER A 1 413 ? 11.708  -32.357 -32.086 1.00 36.68  ? 676  SER A OG  1 
ATOM   2941 N  N   . ALA A 1 414 ? 8.372   -30.664 -31.170 1.00 38.21  ? 677  ALA A N   1 
ATOM   2942 C  CA  . ALA A 1 414 ? 7.760   -29.332 -31.382 1.00 36.05  ? 677  ALA A CA  1 
ATOM   2943 C  C   . ALA A 1 414 ? 6.969   -28.985 -30.118 1.00 38.17  ? 677  ALA A C   1 
ATOM   2944 O  O   . ALA A 1 414 ? 5.778   -29.415 -29.998 1.00 36.80  ? 677  ALA A O   1 
ATOM   2945 C  CB  . ALA A 1 414 ? 6.919   -29.376 -32.624 1.00 35.85  ? 677  ALA A CB  1 
ATOM   2946 N  N   . LEU A 1 415 ? 7.619   -28.362 -29.154 1.00 30.05  ? 678  LEU A N   1 
ATOM   2947 C  CA  . LEU A 1 415 ? 7.149   -28.221 -27.766 1.00 31.87  ? 678  LEU A CA  1 
ATOM   2948 C  C   . LEU A 1 415 ? 7.010   -26.754 -27.353 1.00 32.80  ? 678  LEU A C   1 
ATOM   2949 O  O   . LEU A 1 415 ? 6.412   -26.547 -26.273 1.00 37.84  ? 678  LEU A O   1 
ATOM   2950 C  CB  . LEU A 1 415 ? 8.064   -28.970 -26.808 1.00 33.06  ? 678  LEU A CB  1 
ATOM   2951 C  CG  . LEU A 1 415 ? 8.106   -30.497 -26.996 1.00 34.71  ? 678  LEU A CG  1 
ATOM   2952 C  CD1 . LEU A 1 415 ? 9.252   -31.115 -26.221 1.00 33.16  ? 678  LEU A CD1 1 
ATOM   2953 C  CD2 . LEU A 1 415 ? 6.780   -31.140 -26.614 1.00 35.13  ? 678  LEU A CD2 1 
ATOM   2954 N  N   . THR A 1 416 ? 7.397   -25.769 -28.174 1.00 32.22  ? 679  THR A N   1 
ATOM   2955 C  CA  . THR A 1 416 ? 7.486   -24.375 -27.628 1.00 35.09  ? 679  THR A CA  1 
ATOM   2956 C  C   . THR A 1 416 ? 6.066   -23.784 -27.482 1.00 32.43  ? 679  THR A C   1 
ATOM   2957 O  O   . THR A 1 416 ? 5.761   -23.265 -26.395 1.00 33.96  ? 679  THR A O   1 
ATOM   2958 C  CB  . THR A 1 416 ? 8.380   -23.460 -28.470 1.00 34.60  ? 679  THR A CB  1 
ATOM   2959 O  OG1 . THR A 1 416 ? 7.889   -23.368 -29.808 1.00 37.50  ? 679  THR A OG1 1 
ATOM   2960 C  CG2 . THR A 1 416 ? 9.819   -23.929 -28.538 1.00 35.90  ? 679  THR A CG2 1 
ATOM   2961 N  N   . ALA A 1 417 ? 5.225   -23.887 -28.513 1.00 32.32  ? 680  ALA A N   1 
ATOM   2962 C  CA  . ALA A 1 417 ? 3.805   -23.422 -28.463 1.00 33.96  ? 680  ALA A CA  1 
ATOM   2963 C  C   . ALA A 1 417 ? 3.047   -24.222 -27.379 1.00 38.38  ? 680  ALA A C   1 
ATOM   2964 O  O   . ALA A 1 417 ? 2.386   -23.588 -26.487 1.00 41.71  ? 680  ALA A O   1 
ATOM   2965 C  CB  . ALA A 1 417 ? 3.197   -23.509 -29.833 1.00 35.50  ? 680  ALA A CB  1 
ATOM   2966 N  N   . LEU A 1 418 ? 3.196   -25.558 -27.334 1.00 33.81  ? 681  LEU A N   1 
ATOM   2967 C  CA  . LEU A 1 418 ? 2.395   -26.373 -26.392 1.00 33.09  ? 681  LEU A CA  1 
ATOM   2968 C  C   . LEU A 1 418 ? 2.718   -25.922 -24.975 1.00 34.93  ? 681  LEU A C   1 
ATOM   2969 O  O   . LEU A 1 418 ? 1.816   -25.786 -24.198 1.00 33.52  ? 681  LEU A O   1 
ATOM   2970 C  CB  . LEU A 1 418 ? 2.676   -27.862 -26.628 1.00 36.38  ? 681  LEU A CB  1 
ATOM   2971 C  CG  . LEU A 1 418 ? 1.808   -28.814 -25.826 1.00 38.40  ? 681  LEU A CG  1 
ATOM   2972 C  CD1 . LEU A 1 418 ? 0.403   -28.885 -26.425 1.00 39.44  ? 681  LEU A CD1 1 
ATOM   2973 C  CD2 . LEU A 1 418 ? 2.444   -30.198 -25.756 1.00 38.50  ? 681  LEU A CD2 1 
ATOM   2974 N  N   . ASN A 1 419 ? 4.005   -25.749 -24.639 1.00 39.92  ? 682  ASN A N   1 
ATOM   2975 C  CA  . ASN A 1 419 ? 4.449   -25.361 -23.267 1.00 36.11  ? 682  ASN A CA  1 
ATOM   2976 C  C   . ASN A 1 419 ? 4.024   -23.901 -23.017 1.00 33.26  ? 682  ASN A C   1 
ATOM   2977 O  O   . ASN A 1 419 ? 3.536   -23.602 -21.943 1.00 37.99  ? 682  ASN A O   1 
ATOM   2978 C  CB  . ASN A 1 419 ? 5.967   -25.601 -23.122 1.00 39.85  ? 682  ASN A CB  1 
ATOM   2979 C  CG  . ASN A 1 419 ? 6.343   -27.060 -22.824 1.00 41.59  ? 682  ASN A CG  1 
ATOM   2980 O  OD1 . ASN A 1 419 ? 5.563   -27.853 -22.269 1.00 37.91  ? 682  ASN A OD1 1 
ATOM   2981 N  ND2 . ASN A 1 419 ? 7.561   -27.442 -23.147 1.00 38.05  ? 682  ASN A ND2 1 
ATOM   2982 N  N   . ASP A 1 420 ? 4.128   -23.022 -24.007 1.00 32.51  ? 683  ASP A N   1 
ATOM   2983 C  CA  . ASP A 1 420 ? 3.780   -21.586 -23.829 1.00 39.18  ? 683  ASP A CA  1 
ATOM   2984 C  C   . ASP A 1 420 ? 2.245   -21.417 -23.713 1.00 38.53  ? 683  ASP A C   1 
ATOM   2985 O  O   . ASP A 1 420 ? 1.818   -20.475 -23.059 1.00 42.02  ? 683  ASP A O   1 
ATOM   2986 C  CB  . ASP A 1 420 ? 4.319   -20.701 -24.956 1.00 38.35  ? 683  ASP A CB  1 
ATOM   2987 C  CG  . ASP A 1 420 ? 4.262   -19.216 -24.577 1.00 42.44  ? 683  ASP A CG  1 
ATOM   2988 O  OD1 . ASP A 1 420 ? 4.610   -18.901 -23.417 1.00 39.44  ? 683  ASP A OD1 1 
ATOM   2989 O  OD2 . ASP A 1 420 ? 3.818   -18.399 -25.413 1.00 40.11  ? 683  ASP A OD2 1 
ATOM   2990 N  N   . MET A 1 421 ? 1.437   -22.330 -24.264 1.00 40.70  ? 684  MET A N   1 
ATOM   2991 C  CA  . MET A 1 421 ? -0.042  -22.242 -24.138 1.00 37.02  ? 684  MET A CA  1 
ATOM   2992 C  C   . MET A 1 421 ? -0.434  -22.704 -22.739 1.00 36.27  ? 684  MET A C   1 
ATOM   2993 O  O   . MET A 1 421 ? -1.580  -22.501 -22.365 1.00 40.39  ? 684  MET A O   1 
ATOM   2994 C  CB  . MET A 1 421 ? -0.745  -23.061 -25.229 1.00 39.81  ? 684  MET A CB  1 
ATOM   2995 C  CG  . MET A 1 421 ? -0.638  -22.412 -26.588 1.00 38.37  ? 684  MET A CG  1 
ATOM   2996 S  SD  . MET A 1 421 ? -1.509  -23.354 -27.922 1.00 43.29  ? 684  MET A SD  1 
ATOM   2997 C  CE  . MET A 1 421 ? -0.659  -24.930 -27.918 1.00 48.40  ? 684  MET A CE  1 
ATOM   2998 N  N   . GLY A 1 422 ? 0.494   -23.299 -21.988 1.00 38.51  ? 685  GLY A N   1 
ATOM   2999 C  CA  . GLY A 1 422 ? 0.279   -23.837 -20.627 1.00 30.26  ? 685  GLY A CA  1 
ATOM   3000 C  C   . GLY A 1 422 ? -0.114  -25.308 -20.602 1.00 31.58  ? 685  GLY A C   1 
ATOM   3001 O  O   . GLY A 1 422 ? -0.300  -25.853 -19.483 1.00 35.62  ? 685  GLY A O   1 
ATOM   3002 N  N   . LYS A 1 423 ? -0.230  -25.954 -21.754 1.00 30.51  ? 686  LYS A N   1 
ATOM   3003 C  CA  . LYS A 1 423 ? -0.647  -27.387 -21.862 1.00 36.67  ? 686  LYS A CA  1 
ATOM   3004 C  C   . LYS A 1 423 ? 0.566   -28.331 -21.690 1.00 35.22  ? 686  LYS A C   1 
ATOM   3005 O  O   . LYS A 1 423 ? 0.927   -29.111 -22.634 1.00 37.85  ? 686  LYS A O   1 
ATOM   3006 C  CB  . LYS A 1 423 ? -1.389  -27.565 -23.176 1.00 32.57  ? 686  LYS A CB  1 
ATOM   3007 C  CG  . LYS A 1 423 ? -2.524  -26.564 -23.367 1.00 29.37  ? 686  LYS A CG  1 
ATOM   3008 C  CD  . LYS A 1 423 ? -3.478  -26.576 -22.206 1.00 32.50  ? 686  LYS A CD  1 
ATOM   3009 C  CE  . LYS A 1 423 ? -4.657  -25.633 -22.368 1.00 36.98  ? 686  LYS A CE  1 
ATOM   3010 N  NZ  . LYS A 1 423 ? -4.203  -24.211 -22.332 1.00 42.43  ? 686  LYS A NZ  1 
ATOM   3011 N  N   . VAL A 1 424 ? 1.119   -28.298 -20.490 1.00 36.32  ? 687  VAL A N   1 
ATOM   3012 C  CA  . VAL A 1 424 ? 2.366   -29.005 -20.098 1.00 36.87  ? 687  VAL A CA  1 
ATOM   3013 C  C   . VAL A 1 424 ? 2.024   -30.479 -19.972 1.00 34.47  ? 687  VAL A C   1 
ATOM   3014 O  O   . VAL A 1 424 ? 0.987   -30.807 -19.307 1.00 36.61  ? 687  VAL A O   1 
ATOM   3015 C  CB  . VAL A 1 424 ? 2.941   -28.439 -18.779 1.00 47.47  ? 687  VAL A CB  1 
ATOM   3016 C  CG1 . VAL A 1 424 ? 3.917   -29.409 -18.125 1.00 53.39  ? 687  VAL A CG1 1 
ATOM   3017 C  CG2 . VAL A 1 424 ? 3.593   -27.075 -18.989 1.00 42.80  ? 687  VAL A CG2 1 
ATOM   3018 N  N   . ARG A 1 425 ? 2.868   -31.324 -20.561 1.00 33.44  ? 688  ARG A N   1 
ATOM   3019 C  CA  . ARG A 1 425 ? 2.662   -32.792 -20.617 1.00 37.33  ? 688  ARG A CA  1 
ATOM   3020 C  C   . ARG A 1 425 ? 2.872   -33.407 -19.232 1.00 37.51  ? 688  ARG A C   1 
ATOM   3021 O  O   . ARG A 1 425 ? 3.735   -32.913 -18.472 1.00 45.25  ? 688  ARG A O   1 
ATOM   3022 C  CB  . ARG A 1 425 ? 3.558   -33.447 -21.664 1.00 32.69  ? 688  ARG A CB  1 
ATOM   3023 C  CG  . ARG A 1 425 ? 3.174   -33.053 -23.078 1.00 33.18  ? 688  ARG A CG  1 
ATOM   3024 C  CD  . ARG A 1 425 ? 4.278   -33.340 -24.057 1.00 36.37  ? 688  ARG A CD  1 
ATOM   3025 N  NE  . ARG A 1 425 ? 5.546   -32.778 -23.575 1.00 36.45  ? 688  ARG A NE  1 
ATOM   3026 C  CZ  . ARG A 1 425 ? 6.776   -33.234 -23.855 1.00 35.18  ? 688  ARG A CZ  1 
ATOM   3027 N  NH1 . ARG A 1 425 ? 6.982   -34.248 -24.687 1.00 31.79  ? 688  ARG A NH1 1 
ATOM   3028 N  NH2 . ARG A 1 425 ? 7.805   -32.585 -23.329 1.00 36.73  ? 688  ARG A NH2 1 
ATOM   3029 N  N   . LYS A 1 426 ? 2.094   -34.451 -18.927 0.41 36.87  ? 689  LYS A N   1 
ATOM   3030 C  CA  . LYS A 1 426 ? 2.178   -35.265 -17.685 0.41 40.54  ? 689  LYS A CA  1 
ATOM   3031 C  C   . LYS A 1 426 ? 3.283   -36.323 -17.851 0.41 42.21  ? 689  LYS A C   1 
ATOM   3032 O  O   . LYS A 1 426 ? 3.446   -36.837 -18.973 0.41 42.07  ? 689  LYS A O   1 
ATOM   3033 C  CB  . LYS A 1 426 ? 0.822   -35.927 -17.397 0.41 42.22  ? 689  LYS A CB  1 
ATOM   3034 C  CG  . LYS A 1 426 ? 0.621   -36.389 -15.959 0.41 46.33  ? 689  LYS A CG  1 
ATOM   3035 C  CD  . LYS A 1 426 ? -0.778  -36.886 -15.639 0.41 49.21  ? 689  LYS A CD  1 
ATOM   3036 C  CE  . LYS A 1 426 ? -1.005  -38.329 -16.035 0.41 51.82  ? 689  LYS A CE  1 
ATOM   3037 N  NZ  . LYS A 1 426 ? -2.212  -38.897 -15.386 0.41 53.32  ? 689  LYS A NZ  1 
ATOM   3038 N  N   . ASP A 1 427 ? 4.026   -36.621 -16.782 0.41 45.28  ? 690  ASP A N   1 
ATOM   3039 C  CA  . ASP A 1 427 ? 4.960   -37.781 -16.698 0.41 47.88  ? 690  ASP A CA  1 
ATOM   3040 C  C   . ASP A 1 427 ? 6.079   -37.679 -17.752 0.41 48.80  ? 690  ASP A C   1 
ATOM   3041 O  O   . ASP A 1 427 ? 6.474   -38.746 -18.290 0.41 49.83  ? 690  ASP A O   1 
ATOM   3042 C  CB  . ASP A 1 427 ? 4.211   -39.110 -16.882 0.41 49.31  ? 690  ASP A CB  1 
ATOM   3043 C  CG  . ASP A 1 427 ? 3.102   -39.367 -15.876 0.41 52.46  ? 690  ASP A CG  1 
ATOM   3044 O  OD1 . ASP A 1 427 ? 3.224   -38.875 -14.731 0.41 57.84  ? 690  ASP A OD1 1 
ATOM   3045 O  OD2 . ASP A 1 427 ? 2.124   -40.066 -16.241 0.41 48.96  ? 690  ASP A OD2 1 
ATOM   3046 N  N   . ILE A 1 428 ? 6.598   -36.478 -18.041 1.00 44.77  ? 691  ILE A N   1 
ATOM   3047 C  CA  . ILE A 1 428 ? 7.720   -36.345 -19.009 1.00 45.66  ? 691  ILE A CA  1 
ATOM   3048 C  C   . ILE A 1 428 ? 8.307   -34.972 -18.722 1.00 43.40  ? 691  ILE A C   1 
ATOM   3049 O  O   . ILE A 1 428 ? 7.557   -34.131 -18.276 1.00 47.52  ? 691  ILE A O   1 
ATOM   3050 C  CB  . ILE A 1 428 ? 7.324   -36.524 -20.504 1.00 44.88  ? 691  ILE A CB  1 
ATOM   3051 C  CG1 . ILE A 1 428 ? 8.584   -36.620 -21.355 1.00 43.16  ? 691  ILE A CG1 1 
ATOM   3052 C  CG2 . ILE A 1 428 ? 6.445   -35.392 -21.026 1.00 42.92  ? 691  ILE A CG2 1 
ATOM   3053 C  CD1 . ILE A 1 428 ? 8.405   -37.247 -22.683 1.00 45.39  ? 691  ILE A CD1 1 
ATOM   3054 N  N   . GLN A 1 429 ? 9.605   -34.777 -18.903 1.00 47.75  ? 692  GLN A N   1 
ATOM   3055 C  CA  . GLN A 1 429 ? 10.276  -33.501 -18.524 1.00 46.83  ? 692  GLN A CA  1 
ATOM   3056 C  C   . GLN A 1 429 ? 9.946   -32.466 -19.596 1.00 43.48  ? 692  GLN A C   1 
ATOM   3057 O  O   . GLN A 1 429 ? 9.764   -32.808 -20.777 1.00 44.11  ? 692  GLN A O   1 
ATOM   3058 C  CB  . GLN A 1 429 ? 11.786  -33.715 -18.336 1.00 55.74  ? 692  GLN A CB  1 
ATOM   3059 C  CG  . GLN A 1 429 ? 12.103  -34.785 -17.288 1.00 71.97  ? 692  GLN A CG  1 
ATOM   3060 C  CD  . GLN A 1 429 ? 13.519  -35.311 -17.369 1.00 90.80  ? 692  GLN A CD  1 
ATOM   3061 O  OE1 . GLN A 1 429 ? 13.839  -36.166 -18.200 1.00 97.16  ? 692  GLN A OE1 1 
ATOM   3062 N  NE2 . GLN A 1 429 ? 14.383  -34.808 -16.494 1.00 99.89  ? 692  GLN A NE2 1 
ATOM   3063 N  N   . GLN A 1 430 ? 9.927   -31.227 -19.195 1.00 50.04  ? 693  GLN A N   1 
ATOM   3064 C  CA  . GLN A 1 430 ? 9.343   -30.138 -19.989 1.00 52.81  ? 693  GLN A CA  1 
ATOM   3065 C  C   . GLN A 1 430 ? 9.808   -30.250 -21.426 1.00 47.43  ? 693  GLN A C   1 
ATOM   3066 O  O   . GLN A 1 430 ? 8.960   -30.008 -22.323 1.00 44.09  ? 693  GLN A O   1 
ATOM   3067 C  CB  . GLN A 1 430 ? 9.696   -28.771 -19.406 1.00 62.72  ? 693  GLN A CB  1 
ATOM   3068 C  CG  . GLN A 1 430 ? 8.912   -27.660 -20.074 1.00 74.55  ? 693  GLN A CG  1 
ATOM   3069 C  CD  . GLN A 1 430 ? 8.710   -26.471 -19.175 1.00 77.71  ? 693  GLN A CD  1 
ATOM   3070 O  OE1 . GLN A 1 430 ? 7.580   -26.146 -18.795 1.00 78.80  ? 693  GLN A OE1 1 
ATOM   3071 N  NE2 . GLN A 1 430 ? 9.815   -25.832 -18.828 1.00 69.66  ? 693  GLN A NE2 1 
ATOM   3072 N  N   . TRP A 1 431 ? 11.105  -30.505 -21.652 1.00 42.61  ? 694  TRP A N   1 
ATOM   3073 C  CA  . TRP A 1 431 ? 11.733  -30.334 -22.994 1.00 40.44  ? 694  TRP A CA  1 
ATOM   3074 C  C   . TRP A 1 431 ? 12.166  -31.667 -23.635 1.00 37.47  ? 694  TRP A C   1 
ATOM   3075 O  O   . TRP A 1 431 ? 12.715  -31.616 -24.731 1.00 42.03  ? 694  TRP A O   1 
ATOM   3076 C  CB  . TRP A 1 431 ? 12.862  -29.305 -22.933 1.00 46.12  ? 694  TRP A CB  1 
ATOM   3077 C  CG  . TRP A 1 431 ? 12.384  -27.946 -22.504 1.00 55.14  ? 694  TRP A CG  1 
ATOM   3078 C  CD1 . TRP A 1 431 ? 12.610  -27.351 -21.300 1.00 53.72  ? 694  TRP A CD1 1 
ATOM   3079 C  CD2 . TRP A 1 431 ? 11.505  -27.050 -23.229 1.00 54.01  ? 694  TRP A CD2 1 
ATOM   3080 N  NE1 . TRP A 1 431 ? 11.972  -26.138 -21.245 1.00 61.67  ? 694  TRP A NE1 1 
ATOM   3081 C  CE2 . TRP A 1 431 ? 11.301  -25.918 -22.414 1.00 54.26  ? 694  TRP A CE2 1 
ATOM   3082 C  CE3 . TRP A 1 431 ? 10.930  -27.060 -24.508 1.00 49.33  ? 694  TRP A CE3 1 
ATOM   3083 C  CZ2 . TRP A 1 431 ? 10.502  -24.844 -22.807 1.00 52.45  ? 694  TRP A CZ2 1 
ATOM   3084 C  CZ3 . TRP A 1 431 ? 10.174  -25.982 -24.918 1.00 49.51  ? 694  TRP A CZ3 1 
ATOM   3085 C  CH2 . TRP A 1 431 ? 9.936   -24.904 -24.062 1.00 51.26  ? 694  TRP A CH2 1 
ATOM   3086 N  N   . GLU A 1 432 ? 11.811  -32.798 -23.043 1.00 39.71  ? 695  GLU A N   1 
ATOM   3087 C  CA  . GLU A 1 432 ? 12.101  -34.157 -23.572 1.00 44.14  ? 695  GLU A CA  1 
ATOM   3088 C  C   . GLU A 1 432 ? 11.050  -34.440 -24.653 1.00 41.63  ? 695  GLU A C   1 
ATOM   3089 O  O   . GLU A 1 432 ? 9.854   -34.204 -24.473 1.00 36.11  ? 695  GLU A O   1 
ATOM   3090 C  CB  . GLU A 1 432 ? 12.102  -35.146 -22.392 1.00 49.46  ? 695  GLU A CB  1 
ATOM   3091 C  CG  . GLU A 1 432 ? 12.889  -36.440 -22.612 1.00 74.19  ? 695  GLU A CG  1 
ATOM   3092 C  CD  . GLU A 1 432 ? 14.378  -36.344 -22.993 1.00 86.67  ? 695  GLU A CD  1 
ATOM   3093 O  OE1 . GLU A 1 432 ? 14.860  -37.297 -23.662 1.00 83.46  ? 695  GLU A OE1 1 
ATOM   3094 O  OE2 . GLU A 1 432 ? 15.075  -35.327 -22.643 1.00 79.85  ? 695  GLU A OE2 1 
ATOM   3095 N  N   . PRO A 1 433 ? 11.488  -34.928 -25.804 1.00 34.74  ? 696  PRO A N   1 
ATOM   3096 C  CA  . PRO A 1 433 ? 10.599  -35.187 -26.922 1.00 34.46  ? 696  PRO A CA  1 
ATOM   3097 C  C   . PRO A 1 433 ? 9.581   -36.254 -26.551 1.00 34.13  ? 696  PRO A C   1 
ATOM   3098 O  O   . PRO A 1 433 ? 9.874   -37.138 -25.800 1.00 31.67  ? 696  PRO A O   1 
ATOM   3099 C  CB  . PRO A 1 433 ? 11.478  -35.728 -28.064 1.00 40.96  ? 696  PRO A CB  1 
ATOM   3100 C  CG  . PRO A 1 433 ? 12.938  -35.492 -27.583 1.00 46.13  ? 696  PRO A CG  1 
ATOM   3101 C  CD  . PRO A 1 433 ? 12.898  -35.308 -26.078 1.00 36.01  ? 696  PRO A CD  1 
ATOM   3102 N  N   . SER A 1 434 ? 8.368   -36.123 -27.070 1.00 30.56  ? 697  SER A N   1 
ATOM   3103 C  CA  . SER A 1 434 ? 7.302   -37.109 -26.839 1.00 29.85  ? 697  SER A CA  1 
ATOM   3104 C  C   . SER A 1 434 ? 7.711   -38.505 -27.328 1.00 31.97  ? 697  SER A C   1 
ATOM   3105 O  O   . SER A 1 434 ? 8.278   -38.619 -28.349 1.00 36.67  ? 697  SER A O   1 
ATOM   3106 C  CB  . SER A 1 434 ? 6.024   -36.634 -27.543 1.00 29.25  ? 697  SER A CB  1 
ATOM   3107 O  OG  . SER A 1 434 ? 5.489   -35.497 -26.906 1.00 26.56  ? 697  SER A OG  1 
ATOM   3108 N  N   . ARG A 1 435 ? 7.367   -39.524 -26.532 0.41 32.30  ? 698  ARG A N   1 
ATOM   3109 C  CA  . ARG A 1 435 ? 7.335   -40.968 -26.901 0.41 34.61  ? 698  ARG A CA  1 
ATOM   3110 C  C   . ARG A 1 435 ? 6.090   -41.222 -27.768 0.41 34.59  ? 698  ARG A C   1 
ATOM   3111 O  O   . ARG A 1 435 ? 4.976   -40.928 -27.294 0.41 37.13  ? 698  ARG A O   1 
ATOM   3112 C  CB  . ARG A 1 435 ? 7.277   -41.847 -25.639 0.41 33.75  ? 698  ARG A CB  1 
ATOM   3113 C  CG  . ARG A 1 435 ? 8.375   -41.561 -24.621 0.41 35.17  ? 698  ARG A CG  1 
ATOM   3114 C  CD  . ARG A 1 435 ? 8.459   -42.559 -23.480 0.41 36.35  ? 698  ARG A CD  1 
ATOM   3115 N  NE  . ARG A 1 435 ? 7.602   -42.178 -22.369 0.41 38.11  ? 698  ARG A NE  1 
ATOM   3116 C  CZ  . ARG A 1 435 ? 7.990   -41.591 -21.239 0.41 39.51  ? 698  ARG A CZ  1 
ATOM   3117 N  NH1 . ARG A 1 435 ? 9.263   -41.307 -21.014 0.41 40.39  ? 698  ARG A NH1 1 
ATOM   3118 N  NH2 . ARG A 1 435 ? 7.089   -41.306 -20.316 0.41 41.75  ? 698  ARG A NH2 1 
ATOM   3119 N  N   . GLY A 1 436 ? 6.258   -41.728 -28.988 1.00 33.07  ? 699  GLY A N   1 
ATOM   3120 C  CA  . GLY A 1 436 ? 5.123   -42.085 -29.843 1.00 38.18  ? 699  GLY A CA  1 
ATOM   3121 C  C   . GLY A 1 436 ? 4.818   -43.573 -29.802 1.00 33.62  ? 699  GLY A C   1 
ATOM   3122 O  O   . GLY A 1 436 ? 5.633   -44.325 -29.301 1.00 33.85  ? 699  GLY A O   1 
ATOM   3123 N  N   . TRP A 1 437 ? 3.700   -43.974 -30.395 1.00 26.49  ? 700  TRP A N   1 
ATOM   3124 C  CA  . TRP A 1 437 ? 3.314   -45.382 -30.500 1.00 26.84  ? 700  TRP A CA  1 
ATOM   3125 C  C   . TRP A 1 437 ? 3.411   -45.778 -31.967 1.00 29.48  ? 700  TRP A C   1 
ATOM   3126 O  O   . TRP A 1 437 ? 2.937   -45.009 -32.828 1.00 29.17  ? 700  TRP A O   1 
ATOM   3127 C  CB  . TRP A 1 437 ? 1.896   -45.525 -29.938 1.00 26.93  ? 700  TRP A CB  1 
ATOM   3128 C  CG  . TRP A 1 437 ? 1.775   -45.092 -28.520 1.00 23.50  ? 700  TRP A CG  1 
ATOM   3129 C  CD1 . TRP A 1 437 ? 1.544   -43.831 -28.060 1.00 27.92  ? 700  TRP A CD1 1 
ATOM   3130 C  CD2 . TRP A 1 437 ? 1.896   -45.927 -27.359 1.00 24.72  ? 700  TRP A CD2 1 
ATOM   3131 N  NE1 . TRP A 1 437 ? 1.493   -43.835 -26.693 1.00 29.17  ? 700  TRP A NE1 1 
ATOM   3132 C  CE2 . TRP A 1 437 ? 1.687   -45.110 -26.242 1.00 24.75  ? 700  TRP A CE2 1 
ATOM   3133 C  CE3 . TRP A 1 437 ? 2.210   -47.252 -27.181 1.00 25.37  ? 700  TRP A CE3 1 
ATOM   3134 C  CZ2 . TRP A 1 437 ? 1.775   -45.575 -24.951 1.00 26.65  ? 700  TRP A CZ2 1 
ATOM   3135 C  CZ3 . TRP A 1 437 ? 2.241   -47.744 -25.904 1.00 30.70  ? 700  TRP A CZ3 1 
ATOM   3136 C  CH2 . TRP A 1 437 ? 2.002   -46.922 -24.815 1.00 27.30  ? 700  TRP A CH2 1 
ATOM   3137 N  N   . ASN A 1 438 ? 3.972   -46.958 -32.243 0.41 29.28  ? 701  ASN A N   1 
ATOM   3138 C  CA  . ASN A 1 438 ? 4.179   -47.479 -33.621 0.41 32.24  ? 701  ASN A CA  1 
ATOM   3139 C  C   . ASN A 1 438 ? 3.120   -48.522 -34.001 0.41 32.45  ? 701  ASN A C   1 
ATOM   3140 O  O   . ASN A 1 438 ? 3.243   -49.105 -35.092 0.41 32.54  ? 701  ASN A O   1 
ATOM   3141 C  CB  . ASN A 1 438 ? 5.596   -48.040 -33.749 0.41 34.98  ? 701  ASN A CB  1 
ATOM   3142 C  CG  . ASN A 1 438 ? 6.618   -47.020 -33.289 0.41 36.20  ? 701  ASN A CG  1 
ATOM   3143 O  OD1 . ASN A 1 438 ? 7.375   -47.266 -32.351 0.41 41.75  ? 701  ASN A OD1 1 
ATOM   3144 N  ND2 . ASN A 1 438 ? 6.592   -45.849 -33.901 0.41 34.35  ? 701  ASN A ND2 1 
ATOM   3145 N  N   . ASP A 1 439 ? 2.115   -48.753 -33.158 0.41 34.54  ? 702  ASP A N   1 
ATOM   3146 C  CA  . ASP A 1 439 ? 0.938   -49.599 -33.514 0.41 35.96  ? 702  ASP A CA  1 
ATOM   3147 C  C   . ASP A 1 439 ? -0.303  -49.007 -32.843 0.41 32.21  ? 702  ASP A C   1 
ATOM   3148 O  O   . ASP A 1 439 ? -0.270  -48.747 -31.627 0.41 32.67  ? 702  ASP A O   1 
ATOM   3149 C  CB  . ASP A 1 439 ? 1.166   -51.062 -33.127 0.41 38.29  ? 702  ASP A CB  1 
ATOM   3150 C  CG  . ASP A 1 439 ? 0.212   -52.063 -33.759 0.41 41.18  ? 702  ASP A CG  1 
ATOM   3151 O  OD1 . ASP A 1 439 ? -0.827  -51.639 -34.331 0.41 45.12  ? 702  ASP A OD1 1 
ATOM   3152 O  OD2 . ASP A 1 439 ? 0.509   -53.278 -33.660 0.41 47.10  ? 702  ASP A OD2 1 
ATOM   3153 N  N   . TRP A 1 440 ? -1.357  -48.825 -33.626 1.00 30.36  ? 703  TRP A N   1 
ATOM   3154 C  CA  . TRP A 1 440 ? -2.647  -48.264 -33.161 1.00 28.11  ? 703  TRP A CA  1 
ATOM   3155 C  C   . TRP A 1 440 ? -3.290  -49.142 -32.070 1.00 26.60  ? 703  TRP A C   1 
ATOM   3156 O  O   . TRP A 1 440 ? -4.018  -48.585 -31.202 1.00 26.78  ? 703  TRP A O   1 
ATOM   3157 C  CB  . TRP A 1 440 ? -3.547  -48.022 -34.358 1.00 28.83  ? 703  TRP A CB  1 
ATOM   3158 C  CG  . TRP A 1 440 ? -4.079  -49.266 -35.024 1.00 29.88  ? 703  TRP A CG  1 
ATOM   3159 C  CD1 . TRP A 1 440 ? -3.563  -49.908 -36.114 1.00 32.41  ? 703  TRP A CD1 1 
ATOM   3160 C  CD2 . TRP A 1 440 ? -5.208  -50.047 -34.633 1.00 29.24  ? 703  TRP A CD2 1 
ATOM   3161 N  NE1 . TRP A 1 440 ? -4.316  -50.991 -36.464 1.00 30.57  ? 703  TRP A NE1 1 
ATOM   3162 C  CE2 . TRP A 1 440 ? -5.322  -51.123 -35.550 1.00 32.84  ? 703  TRP A CE2 1 
ATOM   3163 C  CE3 . TRP A 1 440 ? -6.196  -49.874 -33.680 1.00 29.86  ? 703  TRP A CE3 1 
ATOM   3164 C  CZ2 . TRP A 1 440 ? -6.329  -52.078 -35.487 1.00 29.95  ? 703  TRP A CZ2 1 
ATOM   3165 C  CZ3 . TRP A 1 440 ? -7.203  -50.811 -33.627 1.00 30.32  ? 703  TRP A CZ3 1 
ATOM   3166 C  CH2 . TRP A 1 440 ? -7.262  -51.897 -34.502 1.00 35.34  ? 703  TRP A CH2 1 
ATOM   3167 N  N   . THR A 1 441 ? -2.973  -50.421 -32.019 1.00 24.76  ? 704  THR A N   1 
ATOM   3168 C  CA  . THR A 1 441 ? -3.506  -51.357 -30.994 1.00 27.31  ? 704  THR A CA  1 
ATOM   3169 C  C   . THR A 1 441 ? -2.836  -51.161 -29.638 1.00 25.47  ? 704  THR A C   1 
ATOM   3170 O  O   . THR A 1 441 ? -3.325  -51.744 -28.628 1.00 29.79  ? 704  THR A O   1 
ATOM   3171 C  CB  . THR A 1 441 ? -3.461  -52.836 -31.415 1.00 26.74  ? 704  THR A CB  1 
ATOM   3172 O  OG1 . THR A 1 441 ? -2.100  -53.280 -31.476 1.00 26.68  ? 704  THR A OG1 1 
ATOM   3173 C  CG2 . THR A 1 441 ? -4.134  -53.109 -32.745 1.00 25.78  ? 704  THR A CG2 1 
ATOM   3174 N  N   . GLN A 1 442 ? -1.801  -50.338 -29.549 1.00 27.75  ? 705  GLN A N   1 
ATOM   3175 C  CA  . GLN A 1 442 ? -1.103  -50.045 -28.277 1.00 25.85  ? 705  GLN A CA  1 
ATOM   3176 C  C   . GLN A 1 442 ? -1.466  -48.669 -27.710 1.00 23.23  ? 705  GLN A C   1 
ATOM   3177 O  O   . GLN A 1 442 ? -1.253  -48.480 -26.495 1.00 23.95  ? 705  GLN A O   1 
ATOM   3178 C  CB  . GLN A 1 442 ? 0.400   -50.189 -28.470 1.00 31.57  ? 705  GLN A CB  1 
ATOM   3179 C  CG  . GLN A 1 442 ? 0.728   -51.437 -29.259 1.00 34.79  ? 705  GLN A CG  1 
ATOM   3180 C  CD  . GLN A 1 442 ? 0.455   -52.647 -28.429 1.00 36.86  ? 705  GLN A CD  1 
ATOM   3181 O  OE1 . GLN A 1 442 ? 1.067   -52.771 -27.395 1.00 36.94  ? 705  GLN A OE1 1 
ATOM   3182 N  NE2 . GLN A 1 442 ? -0.422  -53.554 -28.891 1.00 41.63  ? 705  GLN A NE2 1 
ATOM   3183 N  N   . VAL A 1 443 ? -2.055  -47.808 -28.510 1.00 24.62  ? 706  VAL A N   1 
ATOM   3184 C  CA  . VAL A 1 443 ? -2.345  -46.379 -28.181 1.00 27.39  ? 706  VAL A CA  1 
ATOM   3185 C  C   . VAL A 1 443 ? -3.403  -46.323 -27.098 1.00 23.94  ? 706  VAL A C   1 
ATOM   3186 O  O   . VAL A 1 443 ? -4.441  -46.971 -27.201 1.00 26.55  ? 706  VAL A O   1 
ATOM   3187 C  CB  . VAL A 1 443 ? -2.835  -45.565 -29.406 1.00 30.31  ? 706  VAL A CB  1 
ATOM   3188 C  CG1 . VAL A 1 443 ? -3.207  -44.144 -29.041 1.00 35.78  ? 706  VAL A CG1 1 
ATOM   3189 C  CG2 . VAL A 1 443 ? -1.769  -45.527 -30.448 1.00 38.65  ? 706  VAL A CG2 1 
ATOM   3190 N  N   . PRO A 1 444 ? -3.165  -45.566 -26.024 1.00 23.99  ? 707  PRO A N   1 
ATOM   3191 C  CA  . PRO A 1 444 ? -4.191  -45.334 -25.022 1.00 23.48  ? 707  PRO A CA  1 
ATOM   3192 C  C   . PRO A 1 444 ? -5.184  -44.277 -25.531 1.00 23.95  ? 707  PRO A C   1 
ATOM   3193 O  O   . PRO A 1 444 ? -4.720  -43.314 -26.103 1.00 24.02  ? 707  PRO A O   1 
ATOM   3194 C  CB  . PRO A 1 444 ? -3.394  -44.805 -23.828 1.00 26.13  ? 707  PRO A CB  1 
ATOM   3195 C  CG  . PRO A 1 444 ? -2.134  -44.165 -24.432 1.00 26.18  ? 707  PRO A CG  1 
ATOM   3196 C  CD  . PRO A 1 444 ? -1.878  -44.908 -25.731 1.00 25.09  ? 707  PRO A CD  1 
ATOM   3197 N  N   . PHE A 1 445 ? -6.490  -44.446 -25.323 1.00 23.07  ? 708  PHE A N   1 
ATOM   3198 C  CA  . PHE A 1 445 ? -7.489  -43.389 -25.622 1.00 22.08  ? 708  PHE A CA  1 
ATOM   3199 C  C   . PHE A 1 445 ? -8.741  -43.672 -24.805 1.00 22.87  ? 708  PHE A C   1 
ATOM   3200 O  O   . PHE A 1 445 ? -9.212  -44.846 -24.836 1.00 21.29  ? 708  PHE A O   1 
ATOM   3201 C  CB  . PHE A 1 445 ? -7.797  -43.373 -27.129 1.00 23.06  ? 708  PHE A CB  1 
ATOM   3202 C  CG  . PHE A 1 445 ? -8.683  -42.235 -27.621 1.00 28.44  ? 708  PHE A CG  1 
ATOM   3203 C  CD1 . PHE A 1 445 ? -8.404  -40.915 -27.318 1.00 25.14  ? 708  PHE A CD1 1 
ATOM   3204 C  CD2 . PHE A 1 445 ? -9.833  -42.506 -28.364 1.00 29.99  ? 708  PHE A CD2 1 
ATOM   3205 C  CE1 . PHE A 1 445 ? -9.214  -39.882 -27.779 1.00 27.19  ? 708  PHE A CE1 1 
ATOM   3206 C  CE2 . PHE A 1 445 ? -10.586 -41.479 -28.914 1.00 27.65  ? 708  PHE A CE2 1 
ATOM   3207 C  CZ  . PHE A 1 445 ? -10.311 -40.165 -28.543 1.00 28.97  ? 708  PHE A CZ  1 
ATOM   3208 N  N   . CYS A 1 446 ? -9.263  -42.654 -24.115 1.00 24.17  ? 709  CYS A N   1 
ATOM   3209 C  CA  . CYS A 1 446 ? -10.495 -42.719 -23.267 1.00 26.56  ? 709  CYS A CA  1 
ATOM   3210 C  C   . CYS A 1 446 ? -10.414 -43.914 -22.303 1.00 25.94  ? 709  CYS A C   1 
ATOM   3211 O  O   . CYS A 1 446 ? -11.415 -44.680 -22.225 1.00 27.94  ? 709  CYS A O   1 
ATOM   3212 C  CB  . CYS A 1 446 ? -11.697 -42.786 -24.178 1.00 27.65  ? 709  CYS A CB  1 
ATOM   3213 S  SG  . CYS A 1 446 ? -11.868 -41.286 -25.196 1.00 30.69  ? 709  CYS A SG  1 
ATOM   3214 N  N   . SER A 1 447 ? -9.239  -44.109 -21.697 1.00 23.35  ? 710  SER A N   1 
ATOM   3215 C  CA  . SER A 1 447 ? -8.948  -45.119 -20.644 1.00 29.40  ? 710  SER A CA  1 
ATOM   3216 C  C   . SER A 1 447 ? -8.941  -46.539 -21.241 1.00 26.88  ? 710  SER A C   1 
ATOM   3217 O  O   . SER A 1 447 ? -8.881  -47.504 -20.479 1.00 28.53  ? 710  SER A O   1 
ATOM   3218 C  CB  . SER A 1 447 ? -9.974  -45.048 -19.518 1.00 35.43  ? 710  SER A CB  1 
ATOM   3219 O  OG  . SER A 1 447 ? -10.105 -43.744 -19.002 1.00 40.68  ? 710  SER A OG  1 
ATOM   3220 N  N   . HIS A 1 448 ? -8.919  -46.693 -22.558 1.00 23.54  ? 711  HIS A N   1 
ATOM   3221 C  CA  . HIS A 1 448 ? -8.907  -48.022 -23.217 1.00 21.32  ? 711  HIS A CA  1 
ATOM   3222 C  C   . HIS A 1 448 ? -7.676  -48.218 -24.113 1.00 20.39  ? 711  HIS A C   1 
ATOM   3223 O  O   . HIS A 1 448 ? -6.958  -47.221 -24.463 1.00 22.03  ? 711  HIS A O   1 
ATOM   3224 C  CB  . HIS A 1 448 ? -10.199 -48.227 -23.998 1.00 22.61  ? 711  HIS A CB  1 
ATOM   3225 C  CG  . HIS A 1 448 ? -11.390 -48.454 -23.139 1.00 23.42  ? 711  HIS A CG  1 
ATOM   3226 N  ND1 . HIS A 1 448 ? -11.987 -47.420 -22.421 1.00 23.53  ? 711  HIS A ND1 1 
ATOM   3227 C  CD2 . HIS A 1 448 ? -12.074 -49.591 -22.869 1.00 23.74  ? 711  HIS A CD2 1 
ATOM   3228 C  CE1 . HIS A 1 448 ? -13.003 -47.932 -21.716 1.00 24.69  ? 711  HIS A CE1 1 
ATOM   3229 N  NE2 . HIS A 1 448 ? -13.109 -49.289 -21.998 1.00 22.75  ? 711  HIS A NE2 1 
ATOM   3230 N  N   . HIS A 1 449 ? -7.505  -49.443 -24.572 1.00 19.84  ? 712  HIS A N   1 
ATOM   3231 C  CA  . HIS A 1 449 ? -6.759  -49.779 -25.810 1.00 19.87  ? 712  HIS A CA  1 
ATOM   3232 C  C   . HIS A 1 449 ? -7.668  -50.672 -26.616 1.00 21.31  ? 712  HIS A C   1 
ATOM   3233 O  O   . HIS A 1 449 ? -8.729  -51.011 -26.107 1.00 22.74  ? 712  HIS A O   1 
ATOM   3234 C  CB  . HIS A 1 449 ? -5.443  -50.513 -25.512 1.00 19.67  ? 712  HIS A CB  1 
ATOM   3235 C  CG  . HIS A 1 449 ? -5.625  -51.745 -24.673 1.00 18.54  ? 712  HIS A CG  1 
ATOM   3236 N  ND1 . HIS A 1 449 ? -5.792  -51.664 -23.329 1.00 20.36  ? 712  HIS A ND1 1 
ATOM   3237 C  CD2 . HIS A 1 449 ? -5.722  -53.043 -24.978 1.00 19.33  ? 712  HIS A CD2 1 
ATOM   3238 C  CE1 . HIS A 1 449 ? -5.968  -52.883 -22.824 1.00 19.72  ? 712  HIS A CE1 1 
ATOM   3239 N  NE2 . HIS A 1 449 ? -5.908  -53.752 -23.811 1.00 22.06  ? 712  HIS A NE2 1 
ATOM   3240 N  N   . PHE A 1 450 ? -7.279  -51.007 -27.823 1.00 21.95  ? 713  PHE A N   1 
ATOM   3241 C  CA  . PHE A 1 450 ? -8.183  -51.634 -28.808 1.00 23.54  ? 713  PHE A CA  1 
ATOM   3242 C  C   . PHE A 1 450 ? -7.483  -52.822 -29.457 1.00 24.73  ? 713  PHE A C   1 
ATOM   3243 O  O   . PHE A 1 450 ? -6.283  -52.729 -29.840 1.00 24.94  ? 713  PHE A O   1 
ATOM   3244 C  CB  . PHE A 1 450 ? -8.648  -50.555 -29.803 1.00 25.65  ? 713  PHE A CB  1 
ATOM   3245 C  CG  . PHE A 1 450 ? -9.401  -49.450 -29.106 1.00 21.34  ? 713  PHE A CG  1 
ATOM   3246 C  CD1 . PHE A 1 450 ? -8.721  -48.391 -28.546 1.00 22.45  ? 713  PHE A CD1 1 
ATOM   3247 C  CD2 . PHE A 1 450 ? -10.767 -49.522 -28.943 1.00 25.17  ? 713  PHE A CD2 1 
ATOM   3248 C  CE1 . PHE A 1 450 ? -9.399  -47.406 -27.829 1.00 25.04  ? 713  PHE A CE1 1 
ATOM   3249 C  CE2 . PHE A 1 450 ? -11.442 -48.552 -28.194 1.00 24.17  ? 713  PHE A CE2 1 
ATOM   3250 C  CZ  . PHE A 1 450 ? -10.758 -47.491 -27.667 1.00 24.80  ? 713  PHE A CZ  1 
ATOM   3251 N  N   . HIS A 1 451 ? -8.196  -53.951 -29.548 0.41 24.87  ? 714  HIS A N   1 
ATOM   3252 C  CA  . HIS A 1 451 ? -7.692  -55.210 -30.157 0.41 24.20  ? 714  HIS A CA  1 
ATOM   3253 C  C   . HIS A 1 451 ? -8.369  -55.423 -31.516 0.41 25.86  ? 714  HIS A C   1 
ATOM   3254 O  O   . HIS A 1 451 ? -9.571  -55.085 -31.656 0.41 26.42  ? 714  HIS A O   1 
ATOM   3255 C  CB  . HIS A 1 451 ? -7.926  -56.408 -29.219 0.41 23.48  ? 714  HIS A CB  1 
ATOM   3256 C  CG  . HIS A 1 451 ? -7.201  -56.394 -27.909 0.41 22.14  ? 714  HIS A CG  1 
ATOM   3257 N  ND1 . HIS A 1 451 ? -6.064  -57.135 -27.689 0.41 23.40  ? 714  HIS A ND1 1 
ATOM   3258 C  CD2 . HIS A 1 451 ? -7.491  -55.803 -26.729 0.41 22.14  ? 714  HIS A CD2 1 
ATOM   3259 C  CE1 . HIS A 1 451 ? -5.676  -56.984 -26.429 0.41 23.20  ? 714  HIS A CE1 1 
ATOM   3260 N  NE2 . HIS A 1 451 ? -6.541  -56.163 -25.813 0.41 18.66  ? 714  HIS A NE2 1 
ATOM   3261 N  N   . GLU A 1 452 ? -7.635  -55.980 -32.476 0.41 27.97  ? 715  GLU A N   1 
ATOM   3262 C  CA  . GLU A 1 452 ? -8.180  -56.497 -33.757 0.41 30.39  ? 715  GLU A CA  1 
ATOM   3263 C  C   . GLU A 1 452 ? -8.483  -57.985 -33.568 0.41 30.85  ? 715  GLU A C   1 
ATOM   3264 O  O   . GLU A 1 452 ? -7.571  -58.737 -33.240 0.41 33.50  ? 715  GLU A O   1 
ATOM   3265 C  CB  . GLU A 1 452 ? -7.209  -56.259 -34.914 0.41 33.89  ? 715  GLU A CB  1 
ATOM   3266 C  CG  . GLU A 1 452 ? -7.915  -55.800 -36.179 0.41 40.32  ? 715  GLU A CG  1 
ATOM   3267 C  CD  . GLU A 1 452 ? -7.008  -55.445 -37.352 0.41 45.15  ? 715  GLU A CD  1 
ATOM   3268 O  OE1 . GLU A 1 452 ? -7.453  -54.675 -38.239 0.41 43.91  ? 715  GLU A OE1 1 
ATOM   3269 O  OE2 . GLU A 1 452 ? -5.864  -55.951 -37.384 0.41 53.89  ? 715  GLU A OE2 1 
ATOM   3270 N  N   . LEU A 1 453 ? -9.735  -58.387 -33.737 0.41 29.65  ? 716  LEU A N   1 
ATOM   3271 C  CA  . LEU A 1 453 ? -10.196 -59.761 -33.417 0.41 31.72  ? 716  LEU A CA  1 
ATOM   3272 C  C   . LEU A 1 453 ? -10.842 -60.368 -34.665 0.41 33.19  ? 716  LEU A C   1 
ATOM   3273 O  O   . LEU A 1 453 ? -11.677 -59.688 -35.304 0.41 29.75  ? 716  LEU A O   1 
ATOM   3274 C  CB  . LEU A 1 453 ? -11.166 -59.634 -32.240 0.41 34.51  ? 716  LEU A CB  1 
ATOM   3275 C  CG  . LEU A 1 453 ? -11.807 -60.915 -31.722 0.41 37.23  ? 716  LEU A CG  1 
ATOM   3276 C  CD1 . LEU A 1 453 ? -10.767 -61.998 -31.482 0.41 37.66  ? 716  LEU A CD1 1 
ATOM   3277 C  CD2 . LEU A 1 453 ? -12.572 -60.610 -30.438 0.41 37.77  ? 716  LEU A CD2 1 
ATOM   3278 N  N   . ILE A 1 454 ? -10.421 -61.581 -35.028 0.41 35.05  ? 717  ILE A N   1 
ATOM   3279 C  CA  . ILE A 1 454 ? -10.885 -62.288 -36.256 0.41 35.14  ? 717  ILE A CA  1 
ATOM   3280 C  C   . ILE A 1 454 ? -11.953 -63.302 -35.837 0.41 33.75  ? 717  ILE A C   1 
ATOM   3281 O  O   . ILE A 1 454 ? -11.664 -64.174 -34.995 0.41 32.73  ? 717  ILE A O   1 
ATOM   3282 C  CB  . ILE A 1 454 ? -9.698  -62.919 -37.012 0.41 39.14  ? 717  ILE A CB  1 
ATOM   3283 C  CG1 . ILE A 1 454 ? -8.543  -61.922 -37.167 0.41 40.73  ? 717  ILE A CG1 1 
ATOM   3284 C  CG2 . ILE A 1 454 ? -10.147 -63.456 -38.369 0.41 42.30  ? 717  ILE A CG2 1 
ATOM   3285 C  CD1 . ILE A 1 454 ? -7.262  -62.529 -37.685 0.41 40.34  ? 717  ILE A CD1 1 
ATOM   3286 N  N   . MET A 1 455 ? -13.169 -63.130 -36.348 0.41 33.83  ? 718  MET A N   1 
ATOM   3287 C  CA  . MET A 1 455 ? -14.276 -64.102 -36.177 0.41 35.68  ? 718  MET A CA  1 
ATOM   3288 C  C   . MET A 1 455 ? -13.988 -65.341 -37.027 0.41 36.17  ? 718  MET A C   1 
ATOM   3289 O  O   . MET A 1 455 ? -13.332 -65.212 -38.086 0.41 35.44  ? 718  MET A O   1 
ATOM   3290 C  CB  . MET A 1 455 ? -15.615 -63.493 -36.597 0.41 35.56  ? 718  MET A CB  1 
ATOM   3291 C  CG  . MET A 1 455 ? -16.017 -62.324 -35.730 0.41 35.71  ? 718  MET A CG  1 
ATOM   3292 S  SD  . MET A 1 455 ? -17.692 -61.732 -36.067 0.41 37.30  ? 718  MET A SD  1 
ATOM   3293 C  CE  . MET A 1 455 ? -18.665 -63.053 -35.349 0.41 38.28  ? 718  MET A CE  1 
ATOM   3294 N  N   A LYS A 1 456 ? -14.503 -66.490 -36.597 0.20 37.61  ? 719  LYS A N   1 
ATOM   3295 N  N   B LYS A 1 456 ? -14.489 -66.508 -36.600 0.21 38.53  ? 719  LYS A N   1 
ATOM   3296 C  CA  A LYS A 1 456 ? -14.285 -67.801 -37.264 0.20 38.88  ? 719  LYS A CA  1 
ATOM   3297 C  CA  B LYS A 1 456 ? -14.259 -67.809 -37.289 0.21 40.21  ? 719  LYS A CA  1 
ATOM   3298 C  C   A LYS A 1 456 ? -14.650 -67.690 -38.755 0.20 36.66  ? 719  LYS A C   1 
ATOM   3299 C  C   B LYS A 1 456 ? -14.622 -67.672 -38.777 0.21 37.39  ? 719  LYS A C   1 
ATOM   3300 O  O   A LYS A 1 456 ? -13.984 -68.360 -39.554 0.20 38.02  ? 719  LYS A O   1 
ATOM   3301 O  O   B LYS A 1 456 ? -13.939 -68.309 -39.593 0.21 38.23  ? 719  LYS A O   1 
ATOM   3302 C  CB  A LYS A 1 456 ? -15.033 -68.892 -36.491 0.20 39.93  ? 719  LYS A CB  1 
ATOM   3303 C  CB  B LYS A 1 456 ? -15.010 -68.942 -36.579 0.21 42.29  ? 719  LYS A CB  1 
ATOM   3304 C  CG  A LYS A 1 456 ? -14.457 -69.184 -35.109 0.20 40.60  ? 719  LYS A CG  1 
ATOM   3305 C  CG  B LYS A 1 456 ? -14.488 -70.342 -36.889 0.21 44.45  ? 719  LYS A CG  1 
ATOM   3306 C  CD  A LYS A 1 456 ? -15.222 -70.229 -34.309 0.20 40.81  ? 719  LYS A CD  1 
ATOM   3307 C  CD  B LYS A 1 456 ? -14.932 -71.431 -35.926 0.21 43.96  ? 719  LYS A CD  1 
ATOM   3308 C  CE  A LYS A 1 456 ? -16.459 -69.689 -33.619 0.20 38.79  ? 719  LYS A CE  1 
ATOM   3309 C  CE  B LYS A 1 456 ? -14.694 -72.818 -36.486 0.21 44.51  ? 719  LYS A CE  1 
ATOM   3310 N  NZ  A LYS A 1 456 ? -17.241 -70.778 -32.985 0.20 38.59  ? 719  LYS A NZ  1 
ATOM   3311 N  NZ  B LYS A 1 456 ? -14.884 -73.878 -35.465 0.21 45.76  ? 719  LYS A NZ  1 
ATOM   3312 N  N   . ASP A 1 457 ? -15.592 -66.812 -39.128 0.41 36.83  ? 720  ASP A N   1 
ATOM   3313 C  CA  . ASP A 1 457 ? -16.051 -66.611 -40.534 0.41 37.51  ? 720  ASP A CA  1 
ATOM   3314 C  C   . ASP A 1 457 ? -15.196 -65.562 -41.271 0.41 41.73  ? 720  ASP A C   1 
ATOM   3315 O  O   . ASP A 1 457 ? -15.565 -65.202 -42.410 0.41 40.88  ? 720  ASP A O   1 
ATOM   3316 C  CB  . ASP A 1 457 ? -17.545 -66.254 -40.583 0.41 37.65  ? 720  ASP A CB  1 
ATOM   3317 C  CG  . ASP A 1 457 ? -17.929 -64.874 -40.070 0.41 36.60  ? 720  ASP A CG  1 
ATOM   3318 O  OD1 . ASP A 1 457 ? -17.026 -64.005 -39.948 0.41 33.73  ? 720  ASP A OD1 1 
ATOM   3319 O  OD2 . ASP A 1 457 ? -19.141 -64.669 -39.799 0.41 34.60  ? 720  ASP A OD2 1 
ATOM   3320 N  N   . GLY A 1 458 ? -14.123 -65.059 -40.646 0.41 43.42  ? 721  GLY A N   1 
ATOM   3321 C  CA  . GLY A 1 458 ? -13.156 -64.133 -41.267 0.41 40.41  ? 721  GLY A CA  1 
ATOM   3322 C  C   . GLY A 1 458 ? -13.501 -62.663 -41.076 0.41 41.00  ? 721  GLY A C   1 
ATOM   3323 O  O   . GLY A 1 458 ? -12.675 -61.827 -41.478 0.41 45.34  ? 721  GLY A O   1 
ATOM   3324 N  N   . ARG A 1 459 ? -14.669 -62.324 -40.512 1.00 38.29  ? 722  ARG A N   1 
ATOM   3325 C  CA  . ARG A 1 459 ? -15.051 -60.900 -40.355 1.00 33.65  ? 722  ARG A CA  1 
ATOM   3326 C  C   . ARG A 1 459 ? -14.207 -60.286 -39.197 1.00 36.98  ? 722  ARG A C   1 
ATOM   3327 O  O   . ARG A 1 459 ? -13.794 -60.986 -38.257 1.00 34.83  ? 722  ARG A O   1 
ATOM   3328 C  CB  . ARG A 1 459 ? -16.561 -60.747 -40.221 1.00 35.79  ? 722  ARG A CB  1 
ATOM   3329 C  CG  . ARG A 1 459 ? -17.360 -61.150 -41.459 1.00 33.85  ? 722  ARG A CG  1 
ATOM   3330 C  CD  . ARG A 1 459 ? -18.846 -60.839 -41.280 1.00 35.86  ? 722  ARG A CD  1 
ATOM   3331 N  NE  . ARG A 1 459 ? -19.420 -61.726 -40.303 1.00 36.58  ? 722  ARG A NE  1 
ATOM   3332 C  CZ  . ARG A 1 459 ? -20.687 -61.744 -40.001 1.00 32.78  ? 722  ARG A CZ  1 
ATOM   3333 N  NH1 . ARG A 1 459 ? -21.495 -60.863 -40.565 1.00 34.96  ? 722  ARG A NH1 1 
ATOM   3334 N  NH2 . ARG A 1 459 ? -21.135 -62.626 -39.129 1.00 35.23  ? 722  ARG A NH2 1 
ATOM   3335 N  N   . VAL A 1 460 ? -13.929 -59.006 -39.293 1.00 38.13  ? 723  VAL A N   1 
ATOM   3336 C  CA  . VAL A 1 460 ? -12.992 -58.308 -38.376 1.00 35.14  ? 723  VAL A CA  1 
ATOM   3337 C  C   . VAL A 1 460 ? -13.722 -57.397 -37.411 1.00 30.03  ? 723  VAL A C   1 
ATOM   3338 O  O   . VAL A 1 460 ? -14.359 -56.406 -37.835 1.00 41.60  ? 723  VAL A O   1 
ATOM   3339 C  CB  . VAL A 1 460 ? -11.898 -57.554 -39.139 1.00 39.77  ? 723  VAL A CB  1 
ATOM   3340 C  CG1 . VAL A 1 460 ? -10.952 -56.874 -38.149 1.00 46.50  ? 723  VAL A CG1 1 
ATOM   3341 C  CG2 . VAL A 1 460 ? -11.105 -58.503 -40.020 1.00 39.81  ? 723  VAL A CG2 1 
ATOM   3342 N  N   . LEU A 1 461 ? -13.578 -57.690 -36.114 1.00 27.11  ? 724  LEU A N   1 
ATOM   3343 C  CA  . LEU A 1 461 ? -14.046 -56.801 -35.023 1.00 24.46  ? 724  LEU A CA  1 
ATOM   3344 C  C   . LEU A 1 461 ? -12.863 -55.977 -34.464 1.00 26.70  ? 724  LEU A C   1 
ATOM   3345 O  O   . LEU A 1 461 ? -11.750 -56.526 -34.256 1.00 28.44  ? 724  LEU A O   1 
ATOM   3346 C  CB  . LEU A 1 461 ? -14.659 -57.649 -33.946 1.00 24.99  ? 724  LEU A CB  1 
ATOM   3347 C  CG  . LEU A 1 461 ? -15.825 -58.521 -34.395 1.00 26.66  ? 724  LEU A CG  1 
ATOM   3348 C  CD1 . LEU A 1 461 ? -16.138 -59.494 -33.312 1.00 29.67  ? 724  LEU A CD1 1 
ATOM   3349 C  CD2 . LEU A 1 461 ? -17.040 -57.687 -34.721 1.00 28.96  ? 724  LEU A CD2 1 
ATOM   3350 N  N   . VAL A 1 462 ? -13.064 -54.699 -34.237 1.00 24.36  ? 725  VAL A N   1 
ATOM   3351 C  CA  . VAL A 1 462 ? -12.087 -53.909 -33.443 1.00 23.38  ? 725  VAL A CA  1 
ATOM   3352 C  C   . VAL A 1 462 ? -12.757 -53.617 -32.114 1.00 21.44  ? 725  VAL A C   1 
ATOM   3353 O  O   . VAL A 1 462 ? -13.802 -52.961 -32.111 1.00 24.35  ? 725  VAL A O   1 
ATOM   3354 C  CB  . VAL A 1 462 ? -11.627 -52.673 -34.216 1.00 24.70  ? 725  VAL A CB  1 
ATOM   3355 C  CG1 . VAL A 1 462 ? -10.720 -51.804 -33.317 1.00 24.49  ? 725  VAL A CG1 1 
ATOM   3356 C  CG2 . VAL A 1 462 ? -10.974 -53.058 -35.537 1.00 23.78  ? 725  VAL A CG2 1 
ATOM   3357 N  N   . VAL A 1 463 ? -12.219 -54.150 -31.015 1.00 22.62  ? 726  VAL A N   1 
ATOM   3358 C  CA  . VAL A 1 463 ? -12.913 -54.144 -29.710 1.00 20.77  ? 726  VAL A CA  1 
ATOM   3359 C  C   . VAL A 1 463 ? -12.180 -53.311 -28.683 1.00 20.07  ? 726  VAL A C   1 
ATOM   3360 O  O   . VAL A 1 463 ? -10.946 -53.282 -28.638 1.00 23.97  ? 726  VAL A O   1 
ATOM   3361 C  CB  . VAL A 1 463 ? -13.143 -55.581 -29.212 1.00 22.68  ? 726  VAL A CB  1 
ATOM   3362 C  CG1 . VAL A 1 463 ? -14.018 -56.348 -30.202 1.00 24.65  ? 726  VAL A CG1 1 
ATOM   3363 C  CG2 . VAL A 1 463 ? -11.808 -56.311 -29.037 1.00 20.47  ? 726  VAL A CG2 1 
ATOM   3364 N  N   . PRO A 1 464 ? -12.943 -52.691 -27.760 1.00 21.58  ? 727  PRO A N   1 
ATOM   3365 C  CA  . PRO A 1 464 ? -12.364 -51.968 -26.631 1.00 19.23  ? 727  PRO A CA  1 
ATOM   3366 C  C   . PRO A 1 464 ? -11.938 -52.866 -25.471 1.00 18.95  ? 727  PRO A C   1 
ATOM   3367 O  O   . PRO A 1 464 ? -12.513 -53.949 -25.256 1.00 19.63  ? 727  PRO A O   1 
ATOM   3368 C  CB  . PRO A 1 464 ? -13.508 -51.091 -26.183 1.00 18.28  ? 727  PRO A CB  1 
ATOM   3369 C  CG  . PRO A 1 464 ? -14.761 -52.001 -26.430 1.00 21.82  ? 727  PRO A CG  1 
ATOM   3370 C  CD  . PRO A 1 464 ? -14.433 -52.631 -27.784 1.00 21.29  ? 727  PRO A CD  1 
ATOM   3371 N  N   . CYS A 1 465 ? -10.875 -52.464 -24.774 1.00 20.74  ? 728  CYS A N   1 
ATOM   3372 C  CA  . CYS A 1 465 ? -10.275 -53.306 -23.707 1.00 18.45  ? 728  CYS A CA  1 
ATOM   3373 C  C   . CYS A 1 465 ? -9.669  -52.412 -22.640 1.00 20.84  ? 728  CYS A C   1 
ATOM   3374 O  O   . CYS A 1 465 ? -9.200  -51.346 -22.981 1.00 20.70  ? 728  CYS A O   1 
ATOM   3375 C  CB  . CYS A 1 465 ? -9.262  -54.313 -24.269 1.00 20.17  ? 728  CYS A CB  1 
ATOM   3376 S  SG  . CYS A 1 465 ? -8.813  -55.627 -23.092 1.00 20.24  ? 728  CYS A SG  1 
ATOM   3377 N  N   . ARG A 1 466 ? -9.616  -52.883 -21.396 1.00 21.07  ? 729  ARG A N   1 
ATOM   3378 C  CA  . ARG A 1 466 ? -8.725  -52.301 -20.405 1.00 24.65  ? 729  ARG A CA  1 
ATOM   3379 C  C   . ARG A 1 466 ? -8.454  -53.352 -19.335 1.00 22.18  ? 729  ARG A C   1 
ATOM   3380 O  O   . ARG A 1 466 ? -9.040  -54.459 -19.356 1.00 21.18  ? 729  ARG A O   1 
ATOM   3381 C  CB  . ARG A 1 466 ? -9.301  -51.024 -19.821 1.00 29.17  ? 729  ARG A CB  1 
ATOM   3382 C  CG  . ARG A 1 466 ? -10.633 -51.168 -19.158 1.00 31.72  ? 729  ARG A CG  1 
ATOM   3383 C  CD  . ARG A 1 466 ? -11.314 -49.818 -18.838 1.00 27.37  ? 729  ARG A CD  1 
ATOM   3384 N  NE  . ARG A 1 466 ? -10.744 -49.085 -17.749 1.00 26.44  ? 729  ARG A NE  1 
ATOM   3385 C  CZ  . ARG A 1 466 ? -11.260 -47.959 -17.263 1.00 30.92  ? 729  ARG A CZ  1 
ATOM   3386 N  NH1 . ARG A 1 466 ? -12.446 -47.521 -17.665 1.00 33.45  ? 729  ARG A NH1 1 
ATOM   3387 N  NH2 . ARG A 1 466 ? -10.618 -47.318 -16.332 1.00 32.29  ? 729  ARG A NH2 1 
ATOM   3388 N  N   . ASN A 1 467 ? -7.481  -53.083 -18.508 1.00 21.99  ? 730  ASN A N   1 
ATOM   3389 C  CA  . ASN A 1 467 ? -7.121  -54.053 -17.446 1.00 22.12  ? 730  ASN A CA  1 
ATOM   3390 C  C   . ASN A 1 467 ? -8.413  -54.536 -16.728 1.00 21.73  ? 730  ASN A C   1 
ATOM   3391 O  O   . ASN A 1 467 ? -9.171  -53.724 -16.201 1.00 18.79  ? 730  ASN A O   1 
ATOM   3392 C  CB  . ASN A 1 467 ? -6.083  -53.457 -16.505 1.00 24.93  ? 730  ASN A CB  1 
ATOM   3393 C  CG  . ASN A 1 467 ? -5.785  -54.504 -15.459 1.00 30.84  ? 730  ASN A CG  1 
ATOM   3394 O  OD1 . ASN A 1 467 ? -6.466  -54.558 -14.447 1.00 29.58  ? 730  ASN A OD1 1 
ATOM   3395 N  ND2 . ASN A 1 467 ? -4.866  -55.420 -15.776 1.00 35.78  ? 730  ASN A ND2 1 
ATOM   3396 N  N   . GLN A 1 468 ? -8.595  -55.835 -16.573 1.00 21.28  ? 731  GLN A N   1 
ATOM   3397 C  CA  . GLN A 1 468 ? -9.893  -56.413 -16.142 1.00 22.35  ? 731  GLN A CA  1 
ATOM   3398 C  C   . GLN A 1 468 ? -10.146 -56.099 -14.667 1.00 23.04  ? 731  GLN A C   1 
ATOM   3399 O  O   . GLN A 1 468 ? -11.317 -56.033 -14.254 1.00 21.26  ? 731  GLN A O   1 
ATOM   3400 C  CB  . GLN A 1 468 ? -9.904  -57.878 -16.493 1.00 24.70  ? 731  GLN A CB  1 
ATOM   3401 C  CG  . GLN A 1 468 ? -11.208 -58.548 -16.183 1.00 23.89  ? 731  GLN A CG  1 
ATOM   3402 C  CD  . GLN A 1 468 ? -11.171 -60.034 -16.394 1.00 22.82  ? 731  GLN A CD  1 
ATOM   3403 O  OE1 . GLN A 1 468 ? -11.457 -60.533 -17.460 1.00 23.50  ? 731  GLN A OE1 1 
ATOM   3404 N  NE2 . GLN A 1 468 ? -10.908 -60.783 -15.362 1.00 22.44  ? 731  GLN A NE2 1 
ATOM   3405 N  N   . ASP A 1 469 ? -9.097  -55.871 -13.894 1.00 23.71  ? 732  ASP A N   1 
ATOM   3406 C  CA  . ASP A 1 469 ? -9.258  -55.502 -12.452 1.00 24.91  ? 732  ASP A CA  1 
ATOM   3407 C  C   . ASP A 1 469 ? -10.017 -54.177 -12.369 1.00 24.48  ? 732  ASP A C   1 
ATOM   3408 O  O   . ASP A 1 469 ? -10.803 -53.983 -11.440 1.00 25.63  ? 732  ASP A O   1 
ATOM   3409 C  CB  . ASP A 1 469 ? -7.916  -55.372 -11.745 1.00 24.50  ? 732  ASP A CB  1 
ATOM   3410 C  CG  . ASP A 1 469 ? -7.209  -56.688 -11.455 1.00 26.65  ? 732  ASP A CG  1 
ATOM   3411 O  OD1 . ASP A 1 469 ? -7.822  -57.766 -11.607 1.00 27.46  ? 732  ASP A OD1 1 
ATOM   3412 O  OD2 . ASP A 1 469 ? -6.004  -56.622 -11.129 1.00 31.87  ? 732  ASP A OD2 1 
ATOM   3413 N  N   . GLU A 1 470 ? -9.747  -53.240 -13.276 1.00 23.37  ? 733  GLU A N   1 
ATOM   3414 C  CA  . GLU A 1 470 ? -10.399 -51.925 -13.290 1.00 23.58  ? 733  GLU A CA  1 
ATOM   3415 C  C   . GLU A 1 470 ? -11.893 -52.142 -13.572 1.00 21.27  ? 733  GLU A C   1 
ATOM   3416 O  O   . GLU A 1 470 ? -12.730 -51.441 -12.960 1.00 23.33  ? 733  GLU A O   1 
ATOM   3417 C  CB  . GLU A 1 470 ? -9.853  -51.031 -14.407 1.00 24.82  ? 733  GLU A CB  1 
ATOM   3418 C  CG  . GLU A 1 470 ? -8.377  -50.680 -14.255 1.00 32.33  ? 733  GLU A CG  1 
ATOM   3419 C  CD  . GLU A 1 470 ? -7.751  -49.907 -15.430 1.00 38.74  ? 733  GLU A CD  1 
ATOM   3420 O  OE1 . GLU A 1 470 ? -6.543  -49.911 -15.476 1.00 42.58  ? 733  GLU A OE1 1 
ATOM   3421 O  OE2 . GLU A 1 470 ? -8.477  -49.292 -16.301 1.00 36.88  ? 733  GLU A OE2 1 
ATOM   3422 N  N   . LEU A 1 471 ? -12.225 -53.002 -14.527 1.00 20.71  ? 734  LEU A N   1 
ATOM   3423 C  CA  . LEU A 1 471 ? -13.634 -53.251 -14.904 1.00 20.48  ? 734  LEU A CA  1 
ATOM   3424 C  C   . LEU A 1 471 ? -14.415 -53.880 -13.752 1.00 20.63  ? 734  LEU A C   1 
ATOM   3425 O  O   . LEU A 1 471 ? -15.568 -53.392 -13.386 1.00 21.62  ? 734  LEU A O   1 
ATOM   3426 C  CB  . LEU A 1 471 ? -13.636 -54.101 -16.148 1.00 19.78  ? 734  LEU A CB  1 
ATOM   3427 C  CG  . LEU A 1 471 ? -13.109 -53.359 -17.379 1.00 22.78  ? 734  LEU A CG  1 
ATOM   3428 C  CD1 . LEU A 1 471 ? -13.076 -54.287 -18.589 1.00 23.64  ? 734  LEU A CD1 1 
ATOM   3429 C  CD2 . LEU A 1 471 ? -13.944 -52.164 -17.725 1.00 24.55  ? 734  LEU A CD2 1 
ATOM   3430 N  N   . ILE A 1 472 ? -13.850 -54.903 -13.145 1.00 21.32  ? 735  ILE A N   1 
ATOM   3431 C  CA  . ILE A 1 472 ? -14.545 -55.627 -12.050 1.00 22.44  ? 735  ILE A CA  1 
ATOM   3432 C  C   . ILE A 1 472 ? -14.640 -54.740 -10.818 1.00 22.65  ? 735  ILE A C   1 
ATOM   3433 O  O   . ILE A 1 472 ? -15.733 -54.737 -10.198 1.00 21.62  ? 735  ILE A O   1 
ATOM   3434 C  CB  . ILE A 1 472 ? -13.841 -56.934 -11.749 1.00 21.99  ? 735  ILE A CB  1 
ATOM   3435 C  CG1 . ILE A 1 472 ? -14.064 -57.865 -12.939 1.00 24.65  ? 735  ILE A CG1 1 
ATOM   3436 C  CG2 . ILE A 1 472 ? -14.308 -57.508 -10.424 1.00 21.07  ? 735  ILE A CG2 1 
ATOM   3437 C  CD1 . ILE A 1 472 ? -13.345 -59.146 -12.835 1.00 30.39  ? 735  ILE A CD1 1 
ATOM   3438 N  N   . GLY A 1 473 ? -13.578 -53.979 -10.532 1.00 19.47  ? 736  GLY A N   1 
ATOM   3439 C  CA  . GLY A 1 473 ? -13.551 -53.076 -9.368  1.00 21.16  ? 736  GLY A CA  1 
ATOM   3440 C  C   . GLY A 1 473 ? -14.615 -51.976 -9.469  1.00 23.86  ? 736  GLY A C   1 
ATOM   3441 O  O   . GLY A 1 473 ? -15.260 -51.651 -8.429  1.00 24.50  ? 736  GLY A O   1 
ATOM   3442 N  N   . ARG A 1 474 ? -14.847 -51.443 -10.662 1.00 23.31  ? 737  ARG A N   1 
ATOM   3443 C  CA  . ARG A 1 474 ? -15.861 -50.365 -10.878 1.00 24.94  ? 737  ARG A CA  1 
ATOM   3444 C  C   . ARG A 1 474 ? -17.284 -50.963 -10.733 1.00 23.13  ? 737  ARG A C   1 
ATOM   3445 O  O   . ARG A 1 474 ? -18.156 -50.323 -10.157 1.00 25.04  ? 737  ARG A O   1 
ATOM   3446 C  CB  . ARG A 1 474 ? -15.681 -49.771 -12.298 1.00 27.89  ? 737  ARG A CB  1 
ATOM   3447 C  CG  . ARG A 1 474 ? -14.272 -49.272 -12.589 1.00 46.26  ? 737  ARG A CG  1 
ATOM   3448 C  CD  . ARG A 1 474 ? -13.866 -49.224 -14.077 1.00 55.74  ? 737  ARG A CD  1 
ATOM   3449 N  NE  . ARG A 1 474 ? -14.416 -47.971 -14.569 1.00 69.07  ? 737  ARG A NE  1 
ATOM   3450 C  CZ  . ARG A 1 474 ? -13.978 -46.761 -14.195 1.00 66.29  ? 737  ARG A CZ  1 
ATOM   3451 N  NH1 . ARG A 1 474 ? -14.583 -45.680 -14.669 1.00 71.01  ? 737  ARG A NH1 1 
ATOM   3452 N  NH2 . ARG A 1 474 ? -12.928 -46.642 -13.392 1.00 52.45  ? 737  ARG A NH2 1 
ATOM   3453 N  N   . ALA A 1 475 ? -17.543 -52.112 -11.325 1.00 21.58  ? 738  ALA A N   1 
ATOM   3454 C  CA  . ALA A 1 475 ? -18.885 -52.759 -11.319 1.00 23.29  ? 738  ALA A CA  1 
ATOM   3455 C  C   . ALA A 1 475 ? -19.271 -53.133 -9.866  1.00 23.60  ? 738  ALA A C   1 
ATOM   3456 O  O   . ALA A 1 475 ? -20.519 -53.233 -9.554  1.00 22.87  ? 738  ALA A O   1 
ATOM   3457 C  CB  . ALA A 1 475 ? -18.865 -53.950 -12.258 1.00 20.55  ? 738  ALA A CB  1 
ATOM   3458 N  N   . ARG A 1 476 ? -18.295 -53.240 -8.952  1.00 23.40  ? 739  ARG A N   1 
ATOM   3459 C  CA  . ARG A 1 476 ? -18.534 -53.625 -7.532  1.00 22.06  ? 739  ARG A CA  1 
ATOM   3460 C  C   . ARG A 1 476 ? -18.864 -52.389 -6.703  1.00 23.40  ? 739  ARG A C   1 
ATOM   3461 O  O   . ARG A 1 476 ? -19.160 -52.524 -5.463  1.00 26.63  ? 739  ARG A O   1 
ATOM   3462 C  CB  . ARG A 1 476 ? -17.361 -54.427 -6.942  1.00 22.25  ? 739  ARG A CB  1 
ATOM   3463 C  CG  . ARG A 1 476 ? -17.348 -55.849 -7.464  1.00 22.84  ? 739  ARG A CG  1 
ATOM   3464 C  CD  . ARG A 1 476 ? -16.030 -56.637 -7.264  1.00 25.58  ? 739  ARG A CD  1 
ATOM   3465 N  NE  . ARG A 1 476 ? -15.630 -56.843 -5.899  1.00 24.62  ? 739  ARG A NE  1 
ATOM   3466 C  CZ  . ARG A 1 476 ? -15.312 -58.004 -5.355  1.00 20.57  ? 739  ARG A CZ  1 
ATOM   3467 N  NH1 . ARG A 1 476 ? -15.484 -59.147 -5.960  1.00 23.86  ? 739  ARG A NH1 1 
ATOM   3468 N  NH2 . ARG A 1 476 ? -14.808 -58.015 -4.159  1.00 23.25  ? 739  ARG A NH2 1 
ATOM   3469 N  N   . ILE A 1 477 ? -18.923 -51.236 -7.335  1.00 25.32  ? 740  ILE A N   1 
ATOM   3470 C  CA  . ILE A 1 477 ? -19.139 -49.972 -6.594  1.00 33.24  ? 740  ILE A CA  1 
ATOM   3471 C  C   . ILE A 1 477 ? -20.443 -49.311 -7.008  1.00 36.39  ? 740  ILE A C   1 
ATOM   3472 O  O   . ILE A 1 477 ? -20.762 -49.232 -8.247  1.00 30.47  ? 740  ILE A O   1 
ATOM   3473 C  CB  . ILE A 1 477 ? -17.961 -49.006 -6.783  1.00 31.54  ? 740  ILE A CB  1 
ATOM   3474 C  CG1 . ILE A 1 477 ? -16.720 -49.515 -6.048  1.00 37.13  ? 740  ILE A CG1 1 
ATOM   3475 C  CG2 . ILE A 1 477 ? -18.353 -47.636 -6.303  1.00 37.98  ? 740  ILE A CG2 1 
ATOM   3476 C  CD1 . ILE A 1 477 ? -15.462 -48.730 -6.398  1.00 37.69  ? 740  ILE A CD1 1 
ATOM   3477 N  N   A SER A 1 478 ? -21.230 -48.916 -6.002  0.20 37.20  ? 741  SER A N   1 
ATOM   3478 N  N   B SER A 1 478 ? -21.248 -48.935 -6.007  0.21 36.91  ? 741  SER A N   1 
ATOM   3479 C  CA  A SER A 1 478 ? -22.481 -48.115 -6.136  0.20 41.09  ? 741  SER A CA  1 
ATOM   3480 C  CA  B SER A 1 478 ? -22.489 -48.121 -6.170  0.21 40.52  ? 741  SER A CA  1 
ATOM   3481 C  C   A SER A 1 478 ? -22.342 -46.834 -5.303  0.20 43.81  ? 741  SER A C   1 
ATOM   3482 C  C   B SER A 1 478 ? -22.411 -46.864 -5.289  0.21 43.19  ? 741  SER A C   1 
ATOM   3483 O  O   A SER A 1 478 ? -21.795 -46.893 -4.177  0.20 43.88  ? 741  SER A O   1 
ATOM   3484 O  O   B SER A 1 478 ? -21.982 -46.964 -4.117  0.21 42.64  ? 741  SER A O   1 
ATOM   3485 C  CB  A SER A 1 478 ? -23.694 -48.928 -5.734  0.20 40.82  ? 741  SER A CB  1 
ATOM   3486 C  CB  B SER A 1 478 ? -23.754 -48.927 -5.914  0.21 40.35  ? 741  SER A CB  1 
ATOM   3487 O  OG  A SER A 1 478 ? -24.827 -48.105 -5.468  0.20 38.85  ? 741  SER A OG  1 
ATOM   3488 O  OG  B SER A 1 478 ? -23.616 -49.897 -4.880  0.21 37.62  ? 741  SER A OG  1 
ATOM   3489 N  N   . GLN A 1 479 ? -22.807 -45.710 -5.846  0.41 48.55  ? 742  GLN A N   1 
ATOM   3490 C  CA  . GLN A 1 479 ? -22.713 -44.377 -5.196  0.41 51.65  ? 742  GLN A CA  1 
ATOM   3491 C  C   . GLN A 1 479 ? -24.107 -43.961 -4.714  0.41 53.13  ? 742  GLN A C   1 
ATOM   3492 O  O   . GLN A 1 479 ? -25.094 -44.280 -5.418  0.41 48.88  ? 742  GLN A O   1 
ATOM   3493 C  CB  . GLN A 1 479 ? -22.127 -43.368 -6.188  0.41 55.70  ? 742  GLN A CB  1 
ATOM   3494 C  CG  . GLN A 1 479 ? -20.698 -43.690 -6.614  0.41 59.12  ? 742  GLN A CG  1 
ATOM   3495 C  CD  . GLN A 1 479 ? -19.692 -43.537 -5.494  0.41 58.89  ? 742  GLN A CD  1 
ATOM   3496 O  OE1 . GLN A 1 479 ? -19.894 -42.790 -4.535  0.41 57.54  ? 742  GLN A OE1 1 
ATOM   3497 N  NE2 . GLN A 1 479 ? -18.571 -44.228 -5.621  0.41 62.71  ? 742  GLN A NE2 1 
ATOM   3498 N  N   . GLY A 1 480 ? -24.172 -43.292 -3.558  0.41 53.25  ? 743  GLY A N   1 
ATOM   3499 C  CA  . GLY A 1 480 ? -25.408 -42.718 -2.989  0.41 56.39  ? 743  GLY A CA  1 
ATOM   3500 C  C   . GLY A 1 480 ? -26.059 -43.629 -1.960  0.41 57.15  ? 743  GLY A C   1 
ATOM   3501 O  O   . GLY A 1 480 ? -25.616 -44.783 -1.808  0.41 55.17  ? 743  GLY A O   1 
ATOM   3502 N  N   . ALA A 1 481 ? -27.092 -43.116 -1.285  1.00 61.30  ? 744  ALA A N   1 
ATOM   3503 C  CA  . ALA A 1 481 ? -27.830 -43.822 -0.220  1.00 58.20  ? 744  ALA A CA  1 
ATOM   3504 C  C   . ALA A 1 481 ? -29.198 -44.298 -0.720  1.00 49.25  ? 744  ALA A C   1 
ATOM   3505 O  O   . ALA A 1 481 ? -29.633 -43.900 -1.801  1.00 42.17  ? 744  ALA A O   1 
ATOM   3506 C  CB  . ALA A 1 481 ? -27.966 -42.882 0.973   1.00 63.92  ? 744  ALA A CB  1 
ATOM   3507 N  N   . GLY A 1 482 ? -29.819 -45.157 0.081   1.00 40.93  ? 745  GLY A N   1 
ATOM   3508 C  CA  . GLY A 1 482 ? -31.228 -45.604 -0.014  1.00 39.90  ? 745  GLY A CA  1 
ATOM   3509 C  C   . GLY A 1 482 ? -31.452 -46.546 -1.174  1.00 38.53  ? 745  GLY A C   1 
ATOM   3510 O  O   . GLY A 1 482 ? -32.524 -46.502 -1.751  1.00 42.57  ? 745  GLY A O   1 
ATOM   3511 N  N   . TRP A 1 483 ? -30.459 -47.381 -1.512  0.41 35.82  ? 746  TRP A N   1 
ATOM   3512 C  CA  . TRP A 1 483 ? -30.597 -48.382 -2.603  0.41 34.53  ? 746  TRP A CA  1 
ATOM   3513 C  C   . TRP A 1 483 ? -31.288 -49.642 -2.067  0.41 31.13  ? 746  TRP A C   1 
ATOM   3514 O  O   . TRP A 1 483 ? -30.720 -50.351 -1.209  0.41 29.95  ? 746  TRP A O   1 
ATOM   3515 C  CB  . TRP A 1 483 ? -29.251 -48.716 -3.247  0.41 37.53  ? 746  TRP A CB  1 
ATOM   3516 C  CG  . TRP A 1 483 ? -28.668 -47.639 -4.108  0.41 40.29  ? 746  TRP A CG  1 
ATOM   3517 C  CD1 . TRP A 1 483 ? -28.139 -46.449 -3.693  0.41 44.40  ? 746  TRP A CD1 1 
ATOM   3518 C  CD2 . TRP A 1 483 ? -28.470 -47.687 -5.530  0.41 41.09  ? 746  TRP A CD2 1 
ATOM   3519 N  NE1 . TRP A 1 483 ? -27.653 -45.742 -4.762  0.41 43.74  ? 746  TRP A NE1 1 
ATOM   3520 C  CE2 . TRP A 1 483 ? -27.840 -46.479 -5.902  0.41 43.93  ? 746  TRP A CE2 1 
ATOM   3521 C  CE3 . TRP A 1 483 ? -28.763 -48.625 -6.525  0.41 41.30  ? 746  TRP A CE3 1 
ATOM   3522 C  CZ2 . TRP A 1 483 ? -27.518 -46.186 -7.227  0.41 43.40  ? 746  TRP A CZ2 1 
ATOM   3523 C  CZ3 . TRP A 1 483 ? -28.440 -48.337 -7.833  0.41 41.50  ? 746  TRP A CZ3 1 
ATOM   3524 C  CH2 . TRP A 1 483 ? -27.836 -47.129 -8.178  0.41 42.60  ? 746  TRP A CH2 1 
ATOM   3525 N  N   . SER A 1 484 ? -32.473 -49.932 -2.592  0.41 29.34  ? 747  SER A N   1 
ATOM   3526 C  CA  . SER A 1 484 ? -33.179 -51.219 -2.397  0.41 28.51  ? 747  SER A CA  1 
ATOM   3527 C  C   . SER A 1 484 ? -32.321 -52.364 -2.957  0.41 26.91  ? 747  SER A C   1 
ATOM   3528 O  O   . SER A 1 484 ? -31.346 -52.078 -3.686  0.41 26.53  ? 747  SER A O   1 
ATOM   3529 C  CB  . SER A 1 484 ? -34.530 -51.167 -3.054  0.41 28.33  ? 747  SER A CB  1 
ATOM   3530 O  OG  . SER A 1 484 ? -34.405 -50.686 -4.381  0.41 26.62  ? 747  SER A OG  1 
ATOM   3531 N  N   . LEU A 1 485 ? -32.690 -53.608 -2.641  1.00 24.65  ? 748  LEU A N   1 
ATOM   3532 C  CA  . LEU A 1 485 ? -32.061 -54.809 -3.232  1.00 28.73  ? 748  LEU A CA  1 
ATOM   3533 C  C   . LEU A 1 485 ? -32.371 -54.837 -4.737  1.00 29.90  ? 748  LEU A C   1 
ATOM   3534 O  O   . LEU A 1 485 ? -31.478 -55.118 -5.576  1.00 24.82  ? 748  LEU A O   1 
ATOM   3535 C  CB  . LEU A 1 485 ? -32.553 -56.058 -2.518  1.00 28.03  ? 748  LEU A CB  1 
ATOM   3536 C  CG  . LEU A 1 485 ? -31.946 -57.341 -3.058  1.00 32.43  ? 748  LEU A CG  1 
ATOM   3537 C  CD1 . LEU A 1 485 ? -30.420 -57.187 -3.172  1.00 31.85  ? 748  LEU A CD1 1 
ATOM   3538 C  CD2 . LEU A 1 485 ? -32.324 -58.531 -2.184  1.00 33.99  ? 748  LEU A CD2 1 
ATOM   3539 N  N   . ARG A 1 486 ? -33.590 -54.421 -5.106  1.00 26.81  ? 749  ARG A N   1 
ATOM   3540 C  CA  . ARG A 1 486 ? -33.972 -54.405 -6.524  1.00 26.49  ? 749  ARG A CA  1 
ATOM   3541 C  C   . ARG A 1 486 ? -33.145 -53.378 -7.306  1.00 25.46  ? 749  ARG A C   1 
ATOM   3542 O  O   . ARG A 1 486 ? -32.715 -53.701 -8.376  1.00 25.66  ? 749  ARG A O   1 
ATOM   3543 C  CB  . ARG A 1 486 ? -35.475 -54.128 -6.677  1.00 28.24  ? 749  ARG A CB  1 
ATOM   3544 C  CG  . ARG A 1 486 ? -35.891 -53.880 -8.123  1.00 29.61  ? 749  ARG A CG  1 
ATOM   3545 C  CD  . ARG A 1 486 ? -37.435 -53.949 -8.163  1.00 29.02  ? 749  ARG A CD  1 
ATOM   3546 N  NE  . ARG A 1 486 ? -37.938 -53.826 -9.529  1.00 30.32  ? 749  ARG A NE  1 
ATOM   3547 C  CZ  . ARG A 1 486 ? -39.088 -54.380 -9.917  1.00 29.03  ? 749  ARG A CZ  1 
ATOM   3548 N  NH1 . ARG A 1 486 ? -39.775 -55.104 -9.032  1.00 27.79  ? 749  ARG A NH1 1 
ATOM   3549 N  NH2 . ARG A 1 486 ? -39.516 -54.237 -11.163 1.00 29.85  ? 749  ARG A NH2 1 
ATOM   3550 N  N   . GLU A 1 487 ? -32.977 -52.170 -6.763  0.41 25.29  ? 750  GLU A N   1 
ATOM   3551 C  CA  . GLU A 1 487 ? -32.185 -51.083 -7.403  0.41 26.58  ? 750  GLU A CA  1 
ATOM   3552 C  C   . GLU A 1 487 ? -30.738 -51.575 -7.599  0.41 25.88  ? 750  GLU A C   1 
ATOM   3553 O  O   . GLU A 1 487 ? -30.176 -51.374 -8.696  0.41 23.50  ? 750  GLU A O   1 
ATOM   3554 C  CB  . GLU A 1 487 ? -32.216 -49.804 -6.564  0.41 29.71  ? 750  GLU A CB  1 
ATOM   3555 C  CG  . GLU A 1 487 ? -32.034 -48.547 -7.393  0.41 34.49  ? 750  GLU A CG  1 
ATOM   3556 C  CD  . GLU A 1 487 ? -31.975 -47.220 -6.645  0.41 36.70  ? 750  GLU A CD  1 
ATOM   3557 O  OE1 . GLU A 1 487 ? -32.387 -47.178 -5.456  0.41 36.54  ? 750  GLU A OE1 1 
ATOM   3558 O  OE2 . GLU A 1 487 ? -31.524 -46.214 -7.270  0.41 38.11  ? 750  GLU A OE2 1 
ATOM   3559 N  N   . THR A 1 488 ? -30.190 -52.237 -6.574  1.00 25.23  ? 751  THR A N   1 
ATOM   3560 C  CA  . THR A 1 488 ? -28.776 -52.736 -6.559  1.00 23.10  ? 751  THR A CA  1 
ATOM   3561 C  C   . THR A 1 488 ? -28.654 -53.811 -7.658  1.00 23.28  ? 751  THR A C   1 
ATOM   3562 O  O   . THR A 1 488 ? -27.654 -53.808 -8.451  1.00 25.06  ? 751  THR A O   1 
ATOM   3563 C  CB  . THR A 1 488 ? -28.395 -53.271 -5.195  1.00 22.83  ? 751  THR A CB  1 
ATOM   3564 O  OG1 . THR A 1 488 ? -28.633 -52.228 -4.243  1.00 25.37  ? 751  THR A OG1 1 
ATOM   3565 C  CG2 . THR A 1 488 ? -26.955 -53.754 -5.169  1.00 22.37  ? 751  THR A CG2 1 
ATOM   3566 N  N   . ALA A 1 489 ? -29.623 -54.720 -7.726  1.00 20.68  ? 752  ALA A N   1 
ATOM   3567 C  CA  . ALA A 1 489 ? -29.652 -55.794 -8.727  1.00 22.56  ? 752  ALA A CA  1 
ATOM   3568 C  C   . ALA A 1 489 ? -29.689 -55.203 -10.131 1.00 24.36  ? 752  ALA A C   1 
ATOM   3569 O  O   . ALA A 1 489 ? -28.966 -55.696 -11.020 1.00 23.21  ? 752  ALA A O   1 
ATOM   3570 C  CB  . ALA A 1 489 ? -30.823 -56.702 -8.476  1.00 23.98  ? 752  ALA A CB  1 
ATOM   3571 N  N   . CYS A 1 490 ? -30.480 -54.141 -10.340 1.00 24.70  ? 753  CYS A N   1 
ATOM   3572 C  CA  . CYS A 1 490 ? -30.667 -53.560 -11.698 1.00 22.89  ? 753  CYS A CA  1 
ATOM   3573 C  C   . CYS A 1 490 ? -29.376 -52.816 -12.107 1.00 23.24  ? 753  CYS A C   1 
ATOM   3574 O  O   . CYS A 1 490 ? -29.041 -52.768 -13.303 1.00 22.63  ? 753  CYS A O   1 
ATOM   3575 C  CB  . CYS A 1 490 ? -31.886 -52.621 -11.703 1.00 24.44  ? 753  CYS A CB  1 
ATOM   3576 S  SG  . CYS A 1 490 ? -33.442 -53.584 -11.629 1.00 30.80  ? 753  CYS A SG  1 
ATOM   3577 N  N   . LEU A 1 491 ? -28.663 -52.199 -11.166 1.00 21.41  ? 754  LEU A N   1 
ATOM   3578 C  CA  . LEU A 1 491 ? -27.332 -51.610 -11.482 1.00 22.13  ? 754  LEU A CA  1 
ATOM   3579 C  C   . LEU A 1 491 ? -26.309 -52.709 -11.825 1.00 25.26  ? 754  LEU A C   1 
ATOM   3580 O  O   . LEU A 1 491 ? -25.539 -52.533 -12.742 1.00 25.35  ? 754  LEU A O   1 
ATOM   3581 C  CB  . LEU A 1 491 ? -26.843 -50.805 -10.276 1.00 24.60  ? 754  LEU A CB  1 
ATOM   3582 C  CG  . LEU A 1 491 ? -25.491 -50.132 -10.484 1.00 25.67  ? 754  LEU A CG  1 
ATOM   3583 C  CD1 . LEU A 1 491 ? -25.514 -49.214 -11.690 1.00 27.46  ? 754  LEU A CD1 1 
ATOM   3584 C  CD2 . LEU A 1 491 ? -25.049 -49.366 -9.252  1.00 28.95  ? 754  LEU A CD2 1 
ATOM   3585 N  N   . GLY A 1 492 ? -26.305 -53.830 -11.115 1.00 23.57  ? 755  GLY A N   1 
ATOM   3586 C  CA  . GLY A 1 492 ? -25.417 -54.941 -11.471 1.00 21.62  ? 755  GLY A CA  1 
ATOM   3587 C  C   . GLY A 1 492 ? -25.718 -55.416 -12.884 1.00 23.71  ? 755  GLY A C   1 
ATOM   3588 O  O   . GLY A 1 492 ? -24.791 -55.711 -13.674 1.00 21.72  ? 755  GLY A O   1 
ATOM   3589 N  N   . LYS A 1 493 ? -27.010 -55.460 -13.236 0.41 21.80  ? 756  LYS A N   1 
ATOM   3590 C  CA  . LYS A 1 493 ? -27.448 -55.915 -14.587 0.41 22.86  ? 756  LYS A CA  1 
ATOM   3591 C  C   . LYS A 1 493 ? -26.952 -54.951 -15.668 0.41 21.97  ? 756  LYS A C   1 
ATOM   3592 O  O   . LYS A 1 493 ? -26.608 -55.425 -16.760 0.41 23.44  ? 756  LYS A O   1 
ATOM   3593 C  CB  . LYS A 1 493 ? -28.977 -56.009 -14.640 0.41 23.24  ? 756  LYS A CB  1 
ATOM   3594 C  CG  . LYS A 1 493 ? -29.561 -56.596 -15.915 0.41 25.94  ? 756  LYS A CG  1 
ATOM   3595 C  CD  . LYS A 1 493 ? -31.042 -56.879 -15.795 0.41 26.08  ? 756  LYS A CD  1 
ATOM   3596 C  CE  . LYS A 1 493 ? -31.633 -57.527 -17.027 0.41 27.84  ? 756  LYS A CE  1 
ATOM   3597 N  NZ  . LYS A 1 493 ? -33.039 -57.938 -16.802 0.41 29.33  ? 756  LYS A NZ  1 
ATOM   3598 N  N   . SER A 1 494 ? -26.936 -53.651 -15.372 0.41 22.99  ? 757  SER A N   1 
ATOM   3599 C  CA  . SER A 1 494 ? -26.418 -52.649 -16.339 0.41 23.69  ? 757  SER A CA  1 
ATOM   3600 C  C   . SER A 1 494 ? -24.952 -52.961 -16.675 0.41 22.67  ? 757  SER A C   1 
ATOM   3601 O  O   . SER A 1 494 ? -24.606 -52.951 -17.866 0.41 20.29  ? 757  SER A O   1 
ATOM   3602 C  CB  . SER A 1 494 ? -26.572 -51.251 -15.803 0.41 24.72  ? 757  SER A CB  1 
ATOM   3603 O  OG  . SER A 1 494 ? -27.930 -50.965 -15.512 0.41 27.99  ? 757  SER A OG  1 
ATOM   3604 N  N   . TYR A 1 495 ? -24.134 -53.232 -15.654 1.00 21.07  ? 758  TYR A N   1 
ATOM   3605 C  CA  . TYR A 1 495 ? -22.699 -53.563 -15.885 1.00 23.41  ? 758  TYR A CA  1 
ATOM   3606 C  C   . TYR A 1 495 ? -22.575 -54.868 -16.680 1.00 22.42  ? 758  TYR A C   1 
ATOM   3607 O  O   . TYR A 1 495 ? -21.759 -54.945 -17.584 1.00 23.58  ? 758  TYR A O   1 
ATOM   3608 C  CB  . TYR A 1 495 ? -21.945 -53.626 -14.555 1.00 23.21  ? 758  TYR A CB  1 
ATOM   3609 C  CG  . TYR A 1 495 ? -21.485 -52.286 -14.046 1.00 22.40  ? 758  TYR A CG  1 
ATOM   3610 C  CD1 . TYR A 1 495 ? -20.361 -51.677 -14.571 1.00 24.11  ? 758  TYR A CD1 1 
ATOM   3611 C  CD2 . TYR A 1 495 ? -22.177 -51.622 -13.048 1.00 24.08  ? 758  TYR A CD2 1 
ATOM   3612 C  CE1 . TYR A 1 495 ? -19.931 -50.442 -14.120 1.00 23.09  ? 758  TYR A CE1 1 
ATOM   3613 C  CE2 . TYR A 1 495 ? -21.761 -50.386 -12.586 1.00 25.83  ? 758  TYR A CE2 1 
ATOM   3614 C  CZ  . TYR A 1 495 ? -20.634 -49.794 -13.123 1.00 28.16  ? 758  TYR A CZ  1 
ATOM   3615 O  OH  . TYR A 1 495 ? -20.215 -48.577 -12.675 1.00 29.19  ? 758  TYR A OH  1 
ATOM   3616 N  N   . ALA A 1 496 ? -23.382 -55.861 -16.317 1.00 22.80  ? 759  ALA A N   1 
ATOM   3617 C  CA  . ALA A 1 496 ? -23.332 -57.171 -16.995 1.00 20.70  ? 759  ALA A CA  1 
ATOM   3618 C  C   . ALA A 1 496 ? -23.626 -56.994 -18.487 1.00 21.74  ? 759  ALA A C   1 
ATOM   3619 O  O   . ALA A 1 496 ? -22.908 -57.571 -19.298 1.00 21.48  ? 759  ALA A O   1 
ATOM   3620 C  CB  . ALA A 1 496 ? -24.319 -58.086 -16.339 1.00 21.49  ? 759  ALA A CB  1 
ATOM   3621 N  N   . GLN A 1 497 ? -24.662 -56.222 -18.816 0.41 22.92  ? 760  GLN A N   1 
ATOM   3622 C  CA  . GLN A 1 497 ? -25.057 -56.040 -20.241 0.41 23.54  ? 760  GLN A CA  1 
ATOM   3623 C  C   . GLN A 1 497 ? -23.970 -55.235 -20.969 0.41 22.85  ? 760  GLN A C   1 
ATOM   3624 O  O   . GLN A 1 497 ? -23.678 -55.550 -22.132 0.41 22.29  ? 760  GLN A O   1 
ATOM   3625 C  CB  . GLN A 1 497 ? -26.467 -55.445 -20.307 0.41 24.56  ? 760  GLN A CB  1 
ATOM   3626 C  CG  . GLN A 1 497 ? -27.515 -56.369 -19.700 0.41 25.01  ? 760  GLN A CG  1 
ATOM   3627 C  CD  . GLN A 1 497 ? -28.938 -56.034 -20.074 0.41 25.30  ? 760  GLN A CD  1 
ATOM   3628 O  OE1 . GLN A 1 497 ? -29.816 -56.892 -20.062 0.41 27.11  ? 760  GLN A OE1 1 
ATOM   3629 N  NE2 . GLN A 1 497 ? -29.179 -54.780 -20.411 0.41 26.29  ? 760  GLN A NE2 1 
ATOM   3630 N  N   . MET A 1 498 ? -23.372 -54.257 -20.290 1.00 21.66  ? 761  MET A N   1 
ATOM   3631 C  CA  . MET A 1 498 ? -22.250 -53.502 -20.899 1.00 21.82  ? 761  MET A CA  1 
ATOM   3632 C  C   . MET A 1 498 ? -21.105 -54.466 -21.228 1.00 18.89  ? 761  MET A C   1 
ATOM   3633 O  O   . MET A 1 498 ? -20.571 -54.383 -22.323 1.00 21.78  ? 761  MET A O   1 
ATOM   3634 C  CB  . MET A 1 498 ? -21.738 -52.395 -19.977 1.00 24.30  ? 761  MET A CB  1 
ATOM   3635 C  CG  . MET A 1 498 ? -20.475 -51.737 -20.495 1.00 29.01  ? 761  MET A CG  1 
ATOM   3636 S  SD  . MET A 1 498 ? -19.789 -50.515 -19.364 1.00 38.61  ? 761  MET A SD  1 
ATOM   3637 C  CE  . MET A 1 498 ? -19.182 -51.575 -18.056 1.00 35.52  ? 761  MET A CE  1 
ATOM   3638 N  N   . TRP A 1 499 ? -20.766 -55.350 -20.295 1.00 19.07  ? 762  TRP A N   1 
ATOM   3639 C  CA  . TRP A 1 499 ? -19.678 -56.337 -20.530 1.00 18.30  ? 762  TRP A CA  1 
ATOM   3640 C  C   . TRP A 1 499 ? -20.020 -57.245 -21.729 1.00 22.00  ? 762  TRP A C   1 
ATOM   3641 O  O   . TRP A 1 499 ? -19.125 -57.563 -22.489 1.00 18.58  ? 762  TRP A O   1 
ATOM   3642 C  CB  . TRP A 1 499 ? -19.404 -57.154 -19.266 1.00 19.37  ? 762  TRP A CB  1 
ATOM   3643 C  CG  . TRP A 1 499 ? -18.859 -56.405 -18.091 1.00 19.23  ? 762  TRP A CG  1 
ATOM   3644 C  CD1 . TRP A 1 499 ? -18.400 -55.122 -18.054 1.00 22.42  ? 762  TRP A CD1 1 
ATOM   3645 C  CD2 . TRP A 1 499 ? -18.696 -56.926 -16.762 1.00 19.15  ? 762  TRP A CD2 1 
ATOM   3646 N  NE1 . TRP A 1 499 ? -17.974 -54.807 -16.793 1.00 21.02  ? 762  TRP A NE1 1 
ATOM   3647 C  CE2 . TRP A 1 499 ? -18.138 -55.895 -15.981 1.00 18.87  ? 762  TRP A CE2 1 
ATOM   3648 C  CE3 . TRP A 1 499 ? -18.966 -58.159 -16.160 1.00 22.84  ? 762  TRP A CE3 1 
ATOM   3649 C  CZ2 . TRP A 1 499 ? -17.852 -56.064 -14.629 1.00 20.73  ? 762  TRP A CZ2 1 
ATOM   3650 C  CZ3 . TRP A 1 499 ? -18.684 -58.323 -14.823 1.00 23.54  ? 762  TRP A CZ3 1 
ATOM   3651 C  CH2 . TRP A 1 499 ? -18.134 -57.287 -14.072 1.00 21.25  ? 762  TRP A CH2 1 
ATOM   3652 N  N   . SER A 1 500 ? -21.289 -57.645 -21.858 0.41 19.13  ? 763  SER A N   1 
ATOM   3653 C  CA  . SER A 1 500 ? -21.721 -58.537 -22.965 0.41 19.16  ? 763  SER A CA  1 
ATOM   3654 C  C   . SER A 1 500 ? -21.537 -57.854 -24.323 0.41 18.87  ? 763  SER A C   1 
ATOM   3655 O  O   . SER A 1 500 ? -21.287 -58.568 -25.302 0.41 21.08  ? 763  SER A O   1 
ATOM   3656 C  CB  . SER A 1 500 ? -23.157 -58.967 -22.776 0.41 19.39  ? 763  SER A CB  1 
ATOM   3657 O  OG  . SER A 1 500 ? -23.399 -59.317 -21.425 0.41 19.09  ? 763  SER A OG  1 
ATOM   3658 N  N   . LEU A 1 501 ? -21.661 -56.527 -24.381 0.41 19.88  ? 764  LEU A N   1 
ATOM   3659 C  CA  . LEU A 1 501 ? -21.607 -55.813 -25.689 0.41 20.64  ? 764  LEU A CA  1 
ATOM   3660 C  C   . LEU A 1 501 ? -20.214 -55.232 -25.962 0.41 21.20  ? 764  LEU A C   1 
ATOM   3661 O  O   . LEU A 1 501 ? -19.829 -55.199 -27.136 0.41 21.46  ? 764  LEU A O   1 
ATOM   3662 C  CB  . LEU A 1 501 ? -22.655 -54.695 -25.642 0.41 20.95  ? 764  LEU A CB  1 
ATOM   3663 C  CG  . LEU A 1 501 ? -22.851 -53.910 -26.937 0.41 20.21  ? 764  LEU A CG  1 
ATOM   3664 C  CD1 . LEU A 1 501 ? -23.245 -54.835 -28.077 0.41 20.81  ? 764  LEU A CD1 1 
ATOM   3665 C  CD2 . LEU A 1 501 ? -23.895 -52.820 -26.749 0.41 20.86  ? 764  LEU A CD2 1 
ATOM   3666 N  N   . MET A 1 502 ? -19.497 -54.796 -24.928 0.41 22.09  ? 765  MET A N   1 
ATOM   3667 C  CA  . MET A 1 502 ? -18.187 -54.113 -25.058 0.41 22.78  ? 765  MET A CA  1 
ATOM   3668 C  C   . MET A 1 502 ? -17.061 -55.126 -24.813 0.41 22.84  ? 765  MET A C   1 
ATOM   3669 O  O   . MET A 1 502 ? -16.078 -55.071 -25.555 0.41 21.88  ? 765  MET A O   1 
ATOM   3670 C  CB  . MET A 1 502 ? -18.065 -52.950 -24.072 0.41 25.15  ? 765  MET A CB  1 
ATOM   3671 C  CG  . MET A 1 502 ? -19.191 -51.931 -24.169 0.41 26.33  ? 765  MET A CG  1 
ATOM   3672 S  SD  . MET A 1 502 ? -19.042 -50.818 -25.604 0.41 30.89  ? 765  MET A SD  1 
ATOM   3673 C  CE  . MET A 1 502 ? -19.928 -51.733 -26.854 0.41 31.12  ? 765  MET A CE  1 
ATOM   3674 N  N   . TYR A 1 503 ? -17.194 -56.005 -23.810 1.00 22.17  ? 766  TYR A N   1 
ATOM   3675 C  CA  . TYR A 1 503 ? -16.038 -56.826 -23.331 1.00 22.61  ? 766  TYR A CA  1 
ATOM   3676 C  C   . TYR A 1 503 ? -16.304 -58.341 -23.467 1.00 25.40  ? 766  TYR A C   1 
ATOM   3677 O  O   . TYR A 1 503 ? -15.683 -59.132 -22.717 1.00 21.12  ? 766  TYR A O   1 
ATOM   3678 C  CB  . TYR A 1 503 ? -15.746 -56.396 -21.900 1.00 25.10  ? 766  TYR A CB  1 
ATOM   3679 C  CG  . TYR A 1 503 ? -15.554 -54.909 -21.695 1.00 25.24  ? 766  TYR A CG  1 
ATOM   3680 C  CD1 . TYR A 1 503 ? -14.560 -54.204 -22.348 1.00 24.41  ? 766  TYR A CD1 1 
ATOM   3681 C  CD2 . TYR A 1 503 ? -16.381 -54.181 -20.858 1.00 28.27  ? 766  TYR A CD2 1 
ATOM   3682 C  CE1 . TYR A 1 503 ? -14.392 -52.841 -22.167 1.00 23.41  ? 766  TYR A CE1 1 
ATOM   3683 C  CE2 . TYR A 1 503 ? -16.253 -52.801 -20.700 1.00 27.34  ? 766  TYR A CE2 1 
ATOM   3684 C  CZ  . TYR A 1 503 ? -15.238 -52.123 -21.341 1.00 23.68  ? 766  TYR A CZ  1 
ATOM   3685 O  OH  . TYR A 1 503 ? -15.057 -50.781 -21.130 1.00 23.27  ? 766  TYR A OH  1 
ATOM   3686 N  N   . PHE A 1 504 ? -17.224 -58.754 -24.369 1.00 22.50  ? 767  PHE A N   1 
ATOM   3687 C  CA  . PHE A 1 504 ? -17.599 -60.173 -24.648 1.00 24.01  ? 767  PHE A CA  1 
ATOM   3688 C  C   . PHE A 1 504 ? -16.349 -61.040 -24.921 1.00 22.95  ? 767  PHE A C   1 
ATOM   3689 O  O   . PHE A 1 504 ? -16.358 -62.299 -24.691 1.00 22.23  ? 767  PHE A O   1 
ATOM   3690 C  CB  . PHE A 1 504 ? -18.496 -60.288 -25.884 1.00 22.21  ? 767  PHE A CB  1 
ATOM   3691 C  CG  . PHE A 1 504 ? -17.953 -59.526 -27.067 1.00 21.10  ? 767  PHE A CG  1 
ATOM   3692 C  CD1 . PHE A 1 504 ? -17.173 -60.143 -27.999 1.00 21.99  ? 767  PHE A CD1 1 
ATOM   3693 C  CD2 . PHE A 1 504 ? -18.342 -58.231 -27.303 1.00 23.50  ? 767  PHE A CD2 1 
ATOM   3694 C  CE1 . PHE A 1 504 ? -16.711 -59.446 -29.089 1.00 21.44  ? 767  PHE A CE1 1 
ATOM   3695 C  CE2 . PHE A 1 504 ? -17.891 -57.539 -28.409 1.00 21.44  ? 767  PHE A CE2 1 
ATOM   3696 C  CZ  . PHE A 1 504 ? -17.020 -58.145 -29.257 1.00 22.04  ? 767  PHE A CZ  1 
ATOM   3697 N  N   . HIS A 1 505 ? -15.290 -60.391 -25.385 1.00 23.13  ? 768  HIS A N   1 
ATOM   3698 C  CA  . HIS A 1 505 ? -14.004 -61.050 -25.767 1.00 22.45  ? 768  HIS A CA  1 
ATOM   3699 C  C   . HIS A 1 505 ? -13.124 -61.420 -24.565 1.00 21.56  ? 768  HIS A C   1 
ATOM   3700 O  O   . HIS A 1 505 ? -12.053 -62.036 -24.770 1.00 22.20  ? 768  HIS A O   1 
ATOM   3701 C  CB  . HIS A 1 505 ? -13.232 -60.182 -26.774 1.00 23.27  ? 768  HIS A CB  1 
ATOM   3702 C  CG  . HIS A 1 505 ? -13.121 -58.768 -26.343 1.00 24.30  ? 768  HIS A CG  1 
ATOM   3703 N  ND1 . HIS A 1 505 ? -12.050 -58.316 -25.612 1.00 21.62  ? 768  HIS A ND1 1 
ATOM   3704 C  CD2 . HIS A 1 505 ? -13.959 -57.724 -26.520 1.00 24.01  ? 768  HIS A CD2 1 
ATOM   3705 C  CE1 . HIS A 1 505 ? -12.234 -57.062 -25.359 1.00 21.60  ? 768  HIS A CE1 1 
ATOM   3706 N  NE2 . HIS A 1 505 ? -13.414 -56.639 -25.901 1.00 22.88  ? 768  HIS A NE2 1 
ATOM   3707 N  N   . ARG A 1 506 ? -13.481 -61.016 -23.344 1.00 20.04  ? 769  ARG A N   1 
ATOM   3708 C  CA  . ARG A 1 506 ? -12.761 -61.346 -22.091 1.00 20.47  ? 769  ARG A CA  1 
ATOM   3709 C  C   . ARG A 1 506 ? -13.536 -62.518 -21.454 1.00 22.69  ? 769  ARG A C   1 
ATOM   3710 O  O   . ARG A 1 506 ? -14.765 -62.338 -21.093 1.00 22.21  ? 769  ARG A O   1 
ATOM   3711 C  CB  . ARG A 1 506 ? -12.754 -60.122 -21.163 1.00 20.47  ? 769  ARG A CB  1 
ATOM   3712 C  CG  . ARG A 1 506 ? -12.251 -58.848 -21.817 1.00 19.89  ? 769  ARG A CG  1 
ATOM   3713 C  CD  . ARG A 1 506 ? -10.897 -58.935 -22.515 1.00 21.00  ? 769  ARG A CD  1 
ATOM   3714 N  NE  . ARG A 1 506 ? -9.943  -59.473 -21.552 1.00 21.55  ? 769  ARG A NE  1 
ATOM   3715 C  CZ  . ARG A 1 506 ? -9.455  -58.823 -20.506 1.00 22.66  ? 769  ARG A CZ  1 
ATOM   3716 N  NH1 . ARG A 1 506 ? -8.678  -59.463 -19.638 1.00 22.83  ? 769  ARG A NH1 1 
ATOM   3717 N  NH2 . ARG A 1 506 ? -9.606  -57.517 -20.373 1.00 21.77  ? 769  ARG A NH2 1 
ATOM   3718 N  N   . ARG A 1 507 ? -12.900 -63.674 -21.358 1.00 21.06  ? 770  ARG A N   1 
ATOM   3719 C  CA  . ARG A 1 507 ? -13.503 -64.918 -20.847 1.00 21.67  ? 770  ARG A CA  1 
ATOM   3720 C  C   . ARG A 1 507 ? -14.191 -64.681 -19.509 1.00 21.29  ? 770  ARG A C   1 
ATOM   3721 O  O   . ARG A 1 507 ? -15.378 -65.080 -19.387 1.00 22.10  ? 770  ARG A O   1 
ATOM   3722 C  CB  . ARG A 1 507 ? -12.463 -66.035 -20.742 1.00 24.95  ? 770  ARG A CB  1 
ATOM   3723 C  CG  . ARG A 1 507 ? -11.996 -66.568 -22.101 1.00 25.45  ? 770  ARG A CG  1 
ATOM   3724 C  CD  . ARG A 1 507 ? -10.720 -67.430 -21.965 1.00 26.47  ? 770  ARG A CD  1 
ATOM   3725 N  NE  . ARG A 1 507 ? -10.415 -67.924 -23.297 1.00 25.44  ? 770  ARG A NE  1 
ATOM   3726 C  CZ  . ARG A 1 507 ? -9.806  -67.202 -24.214 1.00 26.83  ? 770  ARG A CZ  1 
ATOM   3727 N  NH1 . ARG A 1 507 ? -9.348  -65.983 -23.945 1.00 24.69  ? 770  ARG A NH1 1 
ATOM   3728 N  NH2 . ARG A 1 507 ? -9.675  -67.692 -25.433 1.00 24.30  ? 770  ARG A NH2 1 
ATOM   3729 N  N   . ASP A 1 508 ? -13.536 -64.052 -18.552 1.00 19.70  ? 771  ASP A N   1 
ATOM   3730 C  CA  . ASP A 1 508 ? -14.082 -63.893 -17.194 1.00 20.22  ? 771  ASP A CA  1 
ATOM   3731 C  C   . ASP A 1 508 ? -15.321 -62.962 -17.257 1.00 23.79  ? 771  ASP A C   1 
ATOM   3732 O  O   . ASP A 1 508 ? -16.238 -63.165 -16.463 1.00 21.11  ? 771  ASP A O   1 
ATOM   3733 C  CB  . ASP A 1 508 ? -13.064 -63.314 -16.221 1.00 20.17  ? 771  ASP A CB  1 
ATOM   3734 C  CG  . ASP A 1 508 ? -11.829 -64.208 -16.024 1.00 22.53  ? 771  ASP A CG  1 
ATOM   3735 O  OD1 . ASP A 1 508 ? -11.832 -65.401 -16.482 1.00 22.88  ? 771  ASP A OD1 1 
ATOM   3736 O  OD2 . ASP A 1 508 ? -10.866 -63.692 -15.430 1.00 22.54  ? 771  ASP A OD2 1 
ATOM   3737 N  N   . LEU A 1 509 ? -15.326 -61.947 -18.121 1.00 20.94  ? 772  LEU A N   1 
ATOM   3738 C  CA  . LEU A 1 509 ? -16.444 -60.957 -18.084 1.00 22.33  ? 772  LEU A CA  1 
ATOM   3739 C  C   . LEU A 1 509 ? -17.650 -61.546 -18.796 1.00 24.63  ? 772  LEU A C   1 
ATOM   3740 O  O   . LEU A 1 509 ? -18.783 -61.252 -18.378 1.00 21.83  ? 772  LEU A O   1 
ATOM   3741 C  CB  . LEU A 1 509 ? -15.997 -59.648 -18.716 1.00 22.60  ? 772  LEU A CB  1 
ATOM   3742 C  CG  . LEU A 1 509 ? -14.859 -58.898 -17.983 1.00 21.01  ? 772  LEU A CG  1 
ATOM   3743 C  CD1 . LEU A 1 509 ? -14.610 -57.514 -18.557 1.00 22.67  ? 772  LEU A CD1 1 
ATOM   3744 C  CD2 . LEU A 1 509 ? -15.137 -58.790 -16.466 1.00 23.43  ? 772  LEU A CD2 1 
ATOM   3745 N  N   . ARG A 1 510 ? -17.471 -62.353 -19.824 1.00 23.74  ? 773  ARG A N   1 
ATOM   3746 C  CA  . ARG A 1 510 ? -18.640 -62.948 -20.495 1.00 23.72  ? 773  ARG A CA  1 
ATOM   3747 C  C   . ARG A 1 510 ? -19.286 -63.945 -19.537 1.00 27.02  ? 773  ARG A C   1 
ATOM   3748 O  O   . ARG A 1 510 ? -20.526 -63.949 -19.465 1.00 25.61  ? 773  ARG A O   1 
ATOM   3749 C  CB  . ARG A 1 510 ? -18.266 -63.637 -21.796 1.00 22.75  ? 773  ARG A CB  1 
ATOM   3750 C  CG  . ARG A 1 510 ? -19.485 -63.964 -22.661 1.00 26.30  ? 773  ARG A CG  1 
ATOM   3751 C  CD  . ARG A 1 510 ? -19.252 -64.844 -23.873 1.00 23.76  ? 773  ARG A CD  1 
ATOM   3752 N  NE  . ARG A 1 510 ? -18.323 -64.283 -24.815 1.00 22.32  ? 773  ARG A NE  1 
ATOM   3753 C  CZ  . ARG A 1 510 ? -18.162 -64.720 -26.056 1.00 26.21  ? 773  ARG A CZ  1 
ATOM   3754 N  NH1 . ARG A 1 510 ? -18.968 -65.666 -26.540 1.00 26.16  ? 773  ARG A NH1 1 
ATOM   3755 N  NH2 . ARG A 1 510 ? -17.281 -64.141 -26.872 1.00 24.82  ? 773  ARG A NH2 1 
ATOM   3756 N  N   . LEU A 1 511 ? -18.490 -64.693 -18.765 1.00 23.90  ? 774  LEU A N   1 
ATOM   3757 C  CA  . LEU A 1 511 ? -19.031 -65.649 -17.765 1.00 24.93  ? 774  LEU A CA  1 
ATOM   3758 C  C   . LEU A 1 511 ? -19.719 -64.841 -16.647 1.00 23.77  ? 774  LEU A C   1 
ATOM   3759 O  O   . LEU A 1 511 ? -20.834 -65.207 -16.276 1.00 22.85  ? 774  LEU A O   1 
ATOM   3760 C  CB  . LEU A 1 511 ? -17.916 -66.557 -17.221 1.00 25.94  ? 774  LEU A CB  1 
ATOM   3761 C  CG  . LEU A 1 511 ? -18.349 -67.847 -16.528 1.00 29.09  ? 774  LEU A CG  1 
ATOM   3762 C  CD1 . LEU A 1 511 ? -17.194 -68.824 -16.435 1.00 30.60  ? 774  LEU A CD1 1 
ATOM   3763 C  CD2 . LEU A 1 511 ? -18.839 -67.562 -15.125 1.00 31.04  ? 774  LEU A CD2 1 
ATOM   3764 N  N   . ALA A 1 512 ? -19.090 -63.831 -16.077 1.00 21.41  ? 775  ALA A N   1 
ATOM   3765 C  CA  . ALA A 1 512 ? -19.662 -63.101 -14.936 1.00 20.28  ? 775  ALA A CA  1 
ATOM   3766 C  C   . ALA A 1 512 ? -20.944 -62.346 -15.388 1.00 22.40  ? 775  ALA A C   1 
ATOM   3767 O  O   . ALA A 1 512 ? -21.940 -62.329 -14.634 1.00 22.22  ? 775  ALA A O   1 
ATOM   3768 C  CB  . ALA A 1 512 ? -18.701 -62.145 -14.358 1.00 19.51  ? 775  ALA A CB  1 
ATOM   3769 N  N   . ALA A 1 513 ? -20.958 -61.828 -16.604 1.00 20.43  ? 776  ALA A N   1 
ATOM   3770 C  CA  . ALA A 1 513 ? -22.136 -61.157 -17.206 1.00 24.49  ? 776  ALA A CA  1 
ATOM   3771 C  C   . ALA A 1 513 ? -23.305 -62.140 -17.314 1.00 23.28  ? 776  ALA A C   1 
ATOM   3772 O  O   . ALA A 1 513 ? -24.480 -61.748 -16.920 1.00 22.97  ? 776  ALA A O   1 
ATOM   3773 C  CB  . ALA A 1 513 ? -21.790 -60.562 -18.555 1.00 24.14  ? 776  ALA A CB  1 
ATOM   3774 N  N   . ASN A 1 514 ? -23.044 -63.330 -17.844 1.00 21.56  ? 777  ASN A N   1 
ATOM   3775 C  CA  . ASN A 1 514 ? -24.088 -64.394 -17.935 1.00 25.39  ? 777  ASN A CA  1 
ATOM   3776 C  C   . ASN A 1 514 ? -24.553 -64.781 -16.528 1.00 24.70  ? 777  ASN A C   1 
ATOM   3777 O  O   . ASN A 1 514 ? -25.776 -64.888 -16.310 1.00 26.95  ? 777  ASN A O   1 
ATOM   3778 C  CB  . ASN A 1 514 ? -23.574 -65.607 -18.684 1.00 28.51  ? 777  ASN A CB  1 
ATOM   3779 C  CG  . ASN A 1 514 ? -23.493 -65.325 -20.169 1.00 30.74  ? 777  ASN A CG  1 
ATOM   3780 O  OD1 . ASN A 1 514 ? -24.356 -64.653 -20.711 1.00 30.50  ? 777  ASN A OD1 1 
ATOM   3781 N  ND2 . ASN A 1 514 ? -22.514 -65.902 -20.830 1.00 29.83  ? 777  ASN A ND2 1 
ATOM   3782 N  N   . ALA A 1 515 ? -23.652 -64.885 -15.567 1.00 23.13  ? 778  ALA A N   1 
ATOM   3783 C  CA  . ALA A 1 515 ? -24.045 -65.223 -14.182 1.00 21.44  ? 778  ALA A CA  1 
ATOM   3784 C  C   . ALA A 1 515 ? -24.959 -64.107 -13.634 1.00 25.03  ? 778  ALA A C   1 
ATOM   3785 O  O   . ALA A 1 515 ? -26.011 -64.426 -13.058 1.00 23.14  ? 778  ALA A O   1 
ATOM   3786 C  CB  . ALA A 1 515 ? -22.859 -65.496 -13.304 1.00 23.10  ? 778  ALA A CB  1 
ATOM   3787 N  N   . ILE A 1 516 ? -24.575 -62.842 -13.718 1.00 23.46  ? 779  ILE A N   1 
ATOM   3788 C  CA  . ILE A 1 516 ? -25.370 -61.723 -13.126 1.00 24.86  ? 779  ILE A CA  1 
ATOM   3789 C  C   . ILE A 1 516 ? -26.761 -61.663 -13.837 1.00 26.12  ? 779  ILE A C   1 
ATOM   3790 O  O   . ILE A 1 516 ? -27.794 -61.607 -13.162 1.00 23.76  ? 779  ILE A O   1 
ATOM   3791 C  CB  . ILE A 1 516 ? -24.640 -60.379 -13.269 1.00 22.86  ? 779  ILE A CB  1 
ATOM   3792 C  CG1 . ILE A 1 516 ? -23.397 -60.308 -12.405 1.00 22.95  ? 779  ILE A CG1 1 
ATOM   3793 C  CG2 . ILE A 1 516 ? -25.579 -59.201 -12.973 1.00 21.54  ? 779  ILE A CG2 1 
ATOM   3794 C  CD1 . ILE A 1 516 ? -22.369 -59.285 -12.884 1.00 23.84  ? 779  ILE A CD1 1 
ATOM   3795 N  N   . CYS A 1 517 ? -26.829 -61.819 -15.157 1.00 23.18  ? 780  CYS A N   1 
ATOM   3796 C  CA  . CYS A 1 517 ? -28.103 -61.800 -15.919 1.00 26.92  ? 780  CYS A CA  1 
ATOM   3797 C  C   . CYS A 1 517 ? -28.988 -63.003 -15.513 1.00 27.39  ? 780  CYS A C   1 
ATOM   3798 O  O   . CYS A 1 517 ? -30.240 -62.884 -15.564 1.00 26.34  ? 780  CYS A O   1 
ATOM   3799 C  CB  . CYS A 1 517 ? -27.884 -61.683 -17.433 1.00 26.20  ? 780  CYS A CB  1 
ATOM   3800 S  SG  . CYS A 1 517 ? -27.257 -60.042 -17.872 1.00 30.57  ? 780  CYS A SG  1 
ATOM   3801 N  N   . SER A 1 518 ? -28.378 -64.109 -15.074 0.41 26.31  ? 781  SER A N   1 
ATOM   3802 C  CA  . SER A 1 518 ? -29.096 -65.334 -14.628 0.41 26.21  ? 781  SER A CA  1 
ATOM   3803 C  C   . SER A 1 518 ? -29.581 -65.166 -13.183 0.41 26.09  ? 781  SER A C   1 
ATOM   3804 O  O   . SER A 1 518 ? -30.504 -65.916 -12.770 0.41 24.62  ? 781  SER A O   1 
ATOM   3805 C  CB  . SER A 1 518 ? -28.248 -66.568 -14.757 0.41 26.18  ? 781  SER A CB  1 
ATOM   3806 O  OG  . SER A 1 518 ? -27.926 -66.834 -16.111 0.41 28.42  ? 781  SER A OG  1 
ATOM   3807 N  N   . ALA A 1 519 ? -28.956 -64.259 -12.426 1.00 23.27  ? 782  ALA A N   1 
ATOM   3808 C  CA  . ALA A 1 519 ? -29.265 -64.075 -10.989 1.00 24.29  ? 782  ALA A CA  1 
ATOM   3809 C  C   . ALA A 1 519 ? -30.282 -62.963 -10.774 1.00 22.82  ? 782  ALA A C   1 
ATOM   3810 O  O   . ALA A 1 519 ? -30.792 -62.883 -9.688  1.00 27.74  ? 782  ALA A O   1 
ATOM   3811 C  CB  . ALA A 1 519 ? -28.008 -63.866 -10.181 1.00 22.03  ? 782  ALA A CB  1 
ATOM   3812 N  N   . VAL A 1 520 ? -30.426 -62.053 -11.718 1.00 22.19  ? 783  VAL A N   1 
ATOM   3813 C  CA  . VAL A 1 520 ? -31.389 -60.933 -11.632 1.00 27.06  ? 783  VAL A CA  1 
ATOM   3814 C  C   . VAL A 1 520 ? -32.642 -61.314 -12.430 1.00 27.76  ? 783  VAL A C   1 
ATOM   3815 O  O   . VAL A 1 520 ? -32.534 -61.823 -13.553 1.00 26.78  ? 783  VAL A O   1 
ATOM   3816 C  CB  . VAL A 1 520 ? -30.728 -59.663 -12.183 1.00 28.11  ? 783  VAL A CB  1 
ATOM   3817 C  CG1 . VAL A 1 520 ? -31.699 -58.498 -12.219 1.00 25.10  ? 783  VAL A CG1 1 
ATOM   3818 C  CG2 . VAL A 1 520 ? -29.492 -59.311 -11.344 1.00 26.53  ? 783  VAL A CG2 1 
ATOM   3819 N  N   . PRO A 1 521 ? -33.866 -61.023 -11.924 0.41 28.78  ? 784  PRO A N   1 
ATOM   3820 C  CA  . PRO A 1 521 ? -35.081 -61.311 -12.680 0.41 28.70  ? 784  PRO A CA  1 
ATOM   3821 C  C   . PRO A 1 521 ? -35.004 -60.774 -14.116 0.41 28.51  ? 784  PRO A C   1 
ATOM   3822 O  O   . PRO A 1 521 ? -34.678 -59.614 -14.296 0.41 27.11  ? 784  PRO A O   1 
ATOM   3823 C  CB  . PRO A 1 521 ? -36.167 -60.607 -11.852 0.41 28.87  ? 784  PRO A CB  1 
ATOM   3824 C  CG  . PRO A 1 521 ? -35.646 -60.701 -10.441 0.41 30.10  ? 784  PRO A CG  1 
ATOM   3825 C  CD  . PRO A 1 521 ? -34.153 -60.466 -10.591 0.41 28.28  ? 784  PRO A CD  1 
ATOM   3826 N  N   A SER A 1 522 ? -35.316 -61.631 -15.086 0.20 29.56  ? 785  SER A N   1 
ATOM   3827 N  N   B SER A 1 522 ? -35.344 -61.629 -15.086 0.21 29.81  ? 785  SER A N   1 
ATOM   3828 C  CA  A SER A 1 522 ? -35.206 -61.378 -16.548 0.20 30.60  ? 785  SER A CA  1 
ATOM   3829 C  CA  B SER A 1 522 ? -35.211 -61.389 -16.549 0.21 30.96  ? 785  SER A CA  1 
ATOM   3830 C  C   A SER A 1 522 ? -35.860 -60.050 -16.945 0.20 34.11  ? 785  SER A C   1 
ATOM   3831 C  C   B SER A 1 522 ? -35.874 -60.071 -16.966 0.21 34.37  ? 785  SER A C   1 
ATOM   3832 O  O   A SER A 1 522 ? -35.288 -59.350 -17.804 0.20 33.13  ? 785  SER A O   1 
ATOM   3833 O  O   B SER A 1 522 ? -35.322 -59.398 -17.860 0.21 33.20  ? 785  SER A O   1 
ATOM   3834 C  CB  A SER A 1 522 ? -35.805 -62.530 -17.322 0.20 31.75  ? 785  SER A CB  1 
ATOM   3835 C  CB  B SER A 1 522 ? -35.783 -62.549 -17.337 0.21 32.36  ? 785  SER A CB  1 
ATOM   3836 O  OG  A SER A 1 522 ? -37.005 -62.977 -16.707 0.20 31.48  ? 785  SER A OG  1 
ATOM   3837 O  OG  B SER A 1 522 ? -35.276 -63.793 -16.867 0.21 32.68  ? 785  SER A OG  1 
ATOM   3838 N  N   . HIS A 1 523 ? -37.025 -59.710 -16.370 0.41 34.55  ? 786  HIS A N   1 
ATOM   3839 C  CA  . HIS A 1 523 ? -37.845 -58.547 -16.805 0.41 34.97  ? 786  HIS A CA  1 
ATOM   3840 C  C   . HIS A 1 523 ? -37.504 -57.277 -16.014 0.41 35.53  ? 786  HIS A C   1 
ATOM   3841 O  O   . HIS A 1 523 ? -38.012 -56.206 -16.392 0.41 37.46  ? 786  HIS A O   1 
ATOM   3842 C  CB  . HIS A 1 523 ? -39.336 -58.920 -16.757 0.41 36.50  ? 786  HIS A CB  1 
ATOM   3843 C  CG  . HIS A 1 523 ? -39.659 -60.105 -17.603 0.41 36.58  ? 786  HIS A CG  1 
ATOM   3844 N  ND1 . HIS A 1 523 ? -39.807 -60.011 -18.975 0.41 38.62  ? 786  HIS A ND1 1 
ATOM   3845 C  CD2 . HIS A 1 523 ? -39.829 -61.409 -17.292 0.41 39.42  ? 786  HIS A CD2 1 
ATOM   3846 C  CE1 . HIS A 1 523 ? -40.072 -61.207 -19.471 0.41 39.39  ? 786  HIS A CE1 1 
ATOM   3847 N  NE2 . HIS A 1 523 ? -40.101 -62.084 -18.459 0.41 38.93  ? 786  HIS A NE2 1 
ATOM   3848 N  N   . TRP A 1 524 ? -36.647 -57.352 -14.991 0.41 36.92  ? 787  TRP A N   1 
ATOM   3849 C  CA  . TRP A 1 524 ? -36.200 -56.145 -14.241 0.41 35.83  ? 787  TRP A CA  1 
ATOM   3850 C  C   . TRP A 1 524 ? -35.298 -55.306 -15.148 0.41 35.26  ? 787  TRP A C   1 
ATOM   3851 O  O   . TRP A 1 524 ? -34.371 -55.872 -15.738 0.41 36.97  ? 787  TRP A O   1 
ATOM   3852 C  CB  . TRP A 1 524 ? -35.509 -56.523 -12.928 0.41 35.54  ? 787  TRP A CB  1 
ATOM   3853 C  CG  . TRP A 1 524 ? -36.454 -56.910 -11.833 0.41 34.59  ? 787  TRP A CG  1 
ATOM   3854 C  CD1 . TRP A 1 524 ? -37.796 -57.140 -11.936 0.41 35.17  ? 787  TRP A CD1 1 
ATOM   3855 C  CD2 . TRP A 1 524 ? -36.112 -57.156 -10.459 0.41 34.82  ? 787  TRP A CD2 1 
ATOM   3856 N  NE1 . TRP A 1 524 ? -38.312 -57.495 -10.719 0.41 35.21  ? 787  TRP A NE1 1 
ATOM   3857 C  CE2 . TRP A 1 524 ? -37.306 -57.501 -9.790  0.41 34.21  ? 787  TRP A CE2 1 
ATOM   3858 C  CE3 . TRP A 1 524 ? -34.920 -57.105 -9.728  0.41 34.79  ? 787  TRP A CE3 1 
ATOM   3859 C  CZ2 . TRP A 1 524 ? -37.338 -57.803 -8.428  0.41 35.46  ? 787  TRP A CZ2 1 
ATOM   3860 C  CZ3 . TRP A 1 524 ? -34.954 -57.408 -8.382  0.41 37.12  ? 787  TRP A CZ3 1 
ATOM   3861 C  CH2 . TRP A 1 524 ? -36.146 -57.752 -7.742  0.41 32.66  ? 787  TRP A CH2 1 
ATOM   3862 N  N   . VAL A 1 525 ? -35.592 -54.013 -15.273 0.41 36.97  ? 788  VAL A N   1 
ATOM   3863 C  CA  . VAL A 1 525 ? -34.924 -53.101 -16.242 0.41 39.58  ? 788  VAL A CA  1 
ATOM   3864 C  C   . VAL A 1 525 ? -33.613 -52.625 -15.623 0.41 40.36  ? 788  VAL A C   1 
ATOM   3865 O  O   . VAL A 1 525 ? -33.578 -52.227 -14.461 0.41 41.41  ? 788  VAL A O   1 
ATOM   3866 C  CB  . VAL A 1 525 ? -35.821 -51.908 -16.625 0.41 41.00  ? 788  VAL A CB  1 
ATOM   3867 C  CG1 . VAL A 1 525 ? -35.159 -51.031 -17.678 0.41 42.02  ? 788  VAL A CG1 1 
ATOM   3868 C  CG2 . VAL A 1 525 ? -37.196 -52.354 -17.090 0.41 42.49  ? 788  VAL A CG2 1 
ATOM   3869 N  N   . PRO A 1 526 ? -32.499 -52.642 -16.384 0.41 42.51  ? 789  PRO A N   1 
ATOM   3870 C  CA  . PRO A 1 526 ? -31.230 -52.087 -15.913 0.41 42.67  ? 789  PRO A CA  1 
ATOM   3871 C  C   . PRO A 1 526 ? -31.327 -50.586 -15.598 0.41 46.11  ? 789  PRO A C   1 
ATOM   3872 O  O   . PRO A 1 526 ? -31.984 -49.882 -16.349 0.41 48.12  ? 789  PRO A O   1 
ATOM   3873 C  CB  . PRO A 1 526 ? -30.256 -52.276 -17.081 0.41 42.02  ? 789  PRO A CB  1 
ATOM   3874 C  CG  . PRO A 1 526 ? -30.928 -53.238 -18.027 0.41 42.92  ? 789  PRO A CG  1 
ATOM   3875 C  CD  . PRO A 1 526 ? -32.409 -53.202 -17.737 0.41 42.49  ? 789  PRO A CD  1 
ATOM   3876 N  N   . THR A 1 527 ? -30.666 -50.139 -14.524 0.41 51.00  ? 790  THR A N   1 
ATOM   3877 C  CA  . THR A 1 527 ? -30.695 -48.735 -14.028 0.41 57.78  ? 790  THR A CA  1 
ATOM   3878 C  C   . THR A 1 527 ? -29.285 -48.156 -13.944 0.41 59.27  ? 790  THR A C   1 
ATOM   3879 O  O   . THR A 1 527 ? -28.316 -48.923 -14.056 0.41 60.66  ? 790  THR A O   1 
ATOM   3880 C  CB  . THR A 1 527 ? -31.330 -48.614 -12.636 0.41 63.93  ? 790  THR A CB  1 
ATOM   3881 O  OG1 . THR A 1 527 ? -30.681 -49.521 -11.740 0.41 64.42  ? 790  THR A OG1 1 
ATOM   3882 C  CG2 . THR A 1 527 ? -32.820 -48.863 -12.667 0.41 65.68  ? 790  THR A CG2 1 
ATOM   3883 N  N   . SER A 1 528 ? -29.213 -46.844 -13.727 0.41 63.10  ? 791  SER A N   1 
ATOM   3884 C  CA  . SER A 1 528 ? -27.975 -46.050 -13.520 0.41 71.65  ? 791  SER A CA  1 
ATOM   3885 C  C   . SER A 1 528 ? -28.375 -44.625 -13.117 0.41 76.33  ? 791  SER A C   1 
ATOM   3886 O  O   . SER A 1 528 ? -28.755 -43.846 -14.020 0.41 79.71  ? 791  SER A O   1 
ATOM   3887 C  CB  . SER A 1 528 ? -27.107 -46.069 -14.760 0.41 69.55  ? 791  SER A CB  1 
ATOM   3888 O  OG  . SER A 1 528 ? -25.944 -45.275 -14.587 0.41 73.13  ? 791  SER A OG  1 
ATOM   3889 N  N   . ARG A 1 529 ? -28.335 -44.320 -11.811 0.41 81.61  ? 792  ARG A N   1 
ATOM   3890 C  CA  . ARG A 1 529 ? -28.618 -42.972 -11.237 0.41 85.81  ? 792  ARG A CA  1 
ATOM   3891 C  C   . ARG A 1 529 ? -27.789 -41.909 -11.975 0.41 90.42  ? 792  ARG A C   1 
ATOM   3892 O  O   . ARG A 1 529 ? -28.298 -40.782 -12.138 0.41 88.44  ? 792  ARG A O   1 
ATOM   3893 C  CB  . ARG A 1 529 ? -28.300 -42.930 -9.738  0.41 83.73  ? 792  ARG A CB  1 
ATOM   3894 C  CG  . ARG A 1 529 ? -29.301 -43.664 -8.858  0.41 83.11  ? 792  ARG A CG  1 
ATOM   3895 C  CD  . ARG A 1 529 ? -29.133 -43.303 -7.390  0.41 82.06  ? 792  ARG A CD  1 
ATOM   3896 N  NE  . ARG A 1 529 ? -29.922 -44.149 -6.499  0.41 80.34  ? 792  ARG A NE  1 
ATOM   3897 C  CZ  . ARG A 1 529 ? -29.957 -44.040 -5.171  0.41 74.56  ? 792  ARG A CZ  1 
ATOM   3898 N  NH1 . ARG A 1 529 ? -29.236 -43.118 -4.553  0.41 71.71  ? 792  ARG A NH1 1 
ATOM   3899 N  NH2 . ARG A 1 529 ? -30.706 -44.869 -4.462  0.41 70.06  ? 792  ARG A NH2 1 
ATOM   3900 N  N   . THR A 1 530 ? -26.560 -42.257 -12.383 0.41 96.01  ? 793  THR A N   1 
ATOM   3901 C  CA  . THR A 1 530 ? -25.635 -41.398 -13.175 0.41 105.06 ? 793  THR A CA  1 
ATOM   3902 C  C   . THR A 1 530 ? -24.899 -42.252 -14.217 0.41 103.69 ? 793  THR A C   1 
ATOM   3903 O  O   . THR A 1 530 ? -24.064 -41.671 -14.945 0.41 101.06 ? 793  THR A O   1 
ATOM   3904 C  CB  . THR A 1 530 ? -24.648 -40.663 -12.257 0.41 109.77 ? 793  THR A CB  1 
ATOM   3905 O  OG1 . THR A 1 530 ? -24.046 -41.625 -11.389 0.41 112.76 ? 793  THR A OG1 1 
ATOM   3906 C  CG2 . THR A 1 530 ? -25.304 -39.575 -11.435 0.41 108.61 ? 793  THR A CG2 1 
ATOM   3907 N  N   . ALA A 1 536 ? -20.713 -40.673 -24.787 0.41 89.32  ? 799  ALA A N   1 
ATOM   3908 C  CA  . ALA A 1 536 ? -20.768 -42.132 -25.051 0.41 89.01  ? 799  ALA A CA  1 
ATOM   3909 C  C   . ALA A 1 536 ? -22.225 -42.593 -25.205 0.41 85.55  ? 799  ALA A C   1 
ATOM   3910 O  O   . ALA A 1 536 ? -23.105 -42.056 -24.494 0.41 83.87  ? 799  ALA A O   1 
ATOM   3911 C  CB  . ALA A 1 536 ? -20.073 -42.888 -23.942 0.41 87.75  ? 799  ALA A CB  1 
ATOM   3912 N  N   . THR A 1 537 ? -22.460 -43.554 -26.105 0.41 80.55  ? 800  THR A N   1 
ATOM   3913 C  CA  . THR A 1 537 ? -23.758 -44.262 -26.286 0.41 76.52  ? 800  THR A CA  1 
ATOM   3914 C  C   . THR A 1 537 ? -23.888 -45.328 -25.190 0.41 68.88  ? 800  THR A C   1 
ATOM   3915 O  O   . THR A 1 537 ? -22.840 -45.739 -24.644 0.41 60.54  ? 800  THR A O   1 
ATOM   3916 C  CB  . THR A 1 537 ? -23.865 -44.864 -27.692 0.41 82.34  ? 800  THR A CB  1 
ATOM   3917 O  OG1 . THR A 1 537 ? -22.843 -45.854 -27.809 0.41 90.28  ? 800  THR A OG1 1 
ATOM   3918 C  CG2 . THR A 1 537 ? -23.729 -43.832 -28.793 0.41 85.00  ? 800  THR A CG2 1 
ATOM   3919 N  N   A HIS A 1 538 ? -25.122 -45.741 -24.868 0.20 60.88  ? 801  HIS A N   1 
ATOM   3920 N  N   B HIS A 1 538 ? -25.127 -45.743 -24.887 0.21 61.99  ? 801  HIS A N   1 
ATOM   3921 C  CA  A HIS A 1 538 ? -25.437 -46.722 -23.793 0.20 54.22  ? 801  HIS A CA  1 
ATOM   3922 C  CA  B HIS A 1 538 ? -25.467 -46.703 -23.799 0.21 55.57  ? 801  HIS A CA  1 
ATOM   3923 C  C   A HIS A 1 538 ? -26.460 -47.743 -24.308 0.20 47.16  ? 801  HIS A C   1 
ATOM   3924 C  C   B HIS A 1 538 ? -26.480 -47.732 -24.319 0.21 48.02  ? 801  HIS A C   1 
ATOM   3925 O  O   A HIS A 1 538 ? -27.570 -47.813 -23.754 0.20 46.86  ? 801  HIS A O   1 
ATOM   3926 O  O   B HIS A 1 538 ? -27.598 -47.801 -23.780 0.21 47.91  ? 801  HIS A O   1 
ATOM   3927 C  CB  A HIS A 1 538 ? -25.910 -45.979 -22.536 0.20 55.75  ? 801  HIS A CB  1 
ATOM   3928 C  CB  B HIS A 1 538 ? -25.945 -45.953 -22.543 0.21 57.99  ? 801  HIS A CB  1 
ATOM   3929 C  CG  A HIS A 1 538 ? -24.817 -45.290 -21.791 0.20 53.83  ? 801  HIS A CG  1 
ATOM   3930 C  CG  B HIS A 1 538 ? -26.766 -44.732 -22.806 0.21 56.44  ? 801  HIS A CG  1 
ATOM   3931 N  ND1 A HIS A 1 538 ? -24.509 -45.604 -20.480 0.20 52.62  ? 801  HIS A ND1 1 
ATOM   3932 N  ND1 B HIS A 1 538 ? -26.658 -43.595 -22.025 0.21 55.54  ? 801  HIS A ND1 1 
ATOM   3933 C  CD2 A HIS A 1 538 ? -23.966 -44.307 -22.158 0.20 52.01  ? 801  HIS A CD2 1 
ATOM   3934 C  CD2 B HIS A 1 538 ? -27.686 -44.453 -23.756 0.21 57.36  ? 801  HIS A CD2 1 
ATOM   3935 C  CE1 A HIS A 1 538 ? -23.512 -44.844 -20.073 0.20 53.65  ? 801  HIS A CE1 1 
ATOM   3936 C  CE1 B HIS A 1 538 ? -27.480 -42.671 -22.482 0.21 58.41  ? 801  HIS A CE1 1 
ATOM   3937 N  NE2 A HIS A 1 538 ? -23.158 -44.043 -21.087 0.20 53.59  ? 801  HIS A NE2 1 
ATOM   3938 N  NE2 B HIS A 1 538 ? -28.123 -43.171 -23.547 0.21 56.21  ? 801  HIS A NE2 1 
ATOM   3939 N  N   . GLU A 1 539 ? -26.082 -48.533 -25.312 0.41 42.06  ? 802  GLU A N   1 
ATOM   3940 C  CA  . GLU A 1 539 ? -26.992 -49.479 -26.009 0.41 41.45  ? 802  GLU A CA  1 
ATOM   3941 C  C   . GLU A 1 539 ? -27.286 -50.689 -25.125 0.41 40.59  ? 802  GLU A C   1 
ATOM   3942 O  O   . GLU A 1 539 ? -28.292 -51.378 -25.406 0.41 39.69  ? 802  GLU A O   1 
ATOM   3943 C  CB  . GLU A 1 539 ? -26.386 -49.959 -27.320 0.41 43.90  ? 802  GLU A CB  1 
ATOM   3944 C  CG  . GLU A 1 539 ? -26.142 -48.838 -28.299 0.41 44.39  ? 802  GLU A CG  1 
ATOM   3945 C  CD  . GLU A 1 539 ? -24.767 -48.210 -28.190 0.41 46.10  ? 802  GLU A CD  1 
ATOM   3946 O  OE1 . GLU A 1 539 ? -24.282 -47.735 -29.231 0.41 49.76  ? 802  GLU A OE1 1 
ATOM   3947 O  OE2 . GLU A 1 539 ? -24.191 -48.184 -27.070 0.41 41.06  ? 802  GLU A OE2 1 
ATOM   3948 N  N   . TRP A 1 540 ? -26.435 -50.954 -24.125 0.41 37.16  ? 803  TRP A N   1 
ATOM   3949 C  CA  . TRP A 1 540 ? -26.630 -52.081 -23.175 0.41 39.46  ? 803  TRP A CA  1 
ATOM   3950 C  C   . TRP A 1 540 ? -27.836 -51.787 -22.276 0.41 40.56  ? 803  TRP A C   1 
ATOM   3951 O  O   . TRP A 1 540 ? -28.403 -52.741 -21.733 0.41 39.49  ? 803  TRP A O   1 
ATOM   3952 C  CB  . TRP A 1 540 ? -25.354 -52.369 -22.368 0.41 37.68  ? 803  TRP A CB  1 
ATOM   3953 C  CG  . TRP A 1 540 ? -24.826 -51.205 -21.588 0.41 34.36  ? 803  TRP A CG  1 
ATOM   3954 C  CD1 . TRP A 1 540 ? -25.186 -50.829 -20.330 0.41 34.25  ? 803  TRP A CD1 1 
ATOM   3955 C  CD2 . TRP A 1 540 ? -23.837 -50.255 -22.024 0.41 34.16  ? 803  TRP A CD2 1 
ATOM   3956 N  NE1 . TRP A 1 540 ? -24.491 -49.713 -19.951 0.41 35.68  ? 803  TRP A NE1 1 
ATOM   3957 C  CE2 . TRP A 1 540 ? -23.655 -49.336 -20.969 0.41 35.80  ? 803  TRP A CE2 1 
ATOM   3958 C  CE3 . TRP A 1 540 ? -23.090 -50.095 -23.195 0.41 36.21  ? 803  TRP A CE3 1 
ATOM   3959 C  CZ2 . TRP A 1 540 ? -22.754 -48.277 -21.054 0.41 37.82  ? 803  TRP A CZ2 1 
ATOM   3960 C  CZ3 . TRP A 1 540 ? -22.201 -49.045 -23.280 0.41 38.64  ? 803  TRP A CZ3 1 
ATOM   3961 C  CH2 . TRP A 1 540 ? -22.033 -48.151 -22.222 0.41 37.45  ? 803  TRP A CH2 1 
ATOM   3962 N  N   . MET A 1 541 ? -28.213 -50.513 -22.133 0.41 43.73  ? 804  MET A N   1 
ATOM   3963 C  CA  . MET A 1 541 ? -29.386 -50.086 -21.326 0.41 45.61  ? 804  MET A CA  1 
ATOM   3964 C  C   . MET A 1 541 ? -30.662 -50.413 -22.119 0.41 47.05  ? 804  MET A C   1 
ATOM   3965 O  O   . MET A 1 541 ? -31.027 -49.630 -23.022 0.41 44.24  ? 804  MET A O   1 
ATOM   3966 C  CB  . MET A 1 541 ? -29.321 -48.592 -20.997 0.41 47.55  ? 804  MET A CB  1 
ATOM   3967 C  CG  . MET A 1 541 ? -28.069 -48.183 -20.227 0.41 49.75  ? 804  MET A CG  1 
ATOM   3968 S  SD  . MET A 1 541 ? -27.890 -49.056 -18.646 0.41 53.18  ? 804  MET A SD  1 
ATOM   3969 C  CE  . MET A 1 541 ? -29.266 -48.368 -17.726 0.41 54.27  ? 804  MET A CE  1 
ATOM   3970 N  N   . THR A 1 542 ? -31.289 -51.551 -21.799 0.41 46.78  ? 805  THR A N   1 
ATOM   3971 C  CA  . THR A 1 542 ? -32.481 -52.115 -22.491 0.41 47.88  ? 805  THR A CA  1 
ATOM   3972 C  C   . THR A 1 542 ? -32.832 -53.476 -21.879 0.41 47.83  ? 805  THR A C   1 
ATOM   3973 O  O   . THR A 1 542 ? -31.997 -54.021 -21.123 0.41 46.95  ? 805  THR A O   1 
ATOM   3974 C  CB  . THR A 1 542 ? -32.249 -52.271 -24.000 0.41 49.58  ? 805  THR A CB  1 
ATOM   3975 O  OG1 . THR A 1 542 ? -33.423 -52.839 -24.586 0.41 49.92  ? 805  THR A OG1 1 
ATOM   3976 C  CG2 . THR A 1 542 ? -31.055 -53.143 -24.323 0.41 51.71  ? 805  THR A CG2 1 
ATOM   3977 N  N   . THR A 1 543 ? -34.015 -54.003 -22.214 0.41 45.56  ? 806  THR A N   1 
ATOM   3978 C  CA  . THR A 1 543 ? -34.523 -55.329 -21.770 0.41 47.34  ? 806  THR A CA  1 
ATOM   3979 C  C   . THR A 1 543 ? -34.525 -56.329 -22.936 0.41 43.72  ? 806  THR A C   1 
ATOM   3980 O  O   . THR A 1 543 ? -34.759 -57.523 -22.674 0.41 45.39  ? 806  THR A O   1 
ATOM   3981 C  CB  . THR A 1 543 ? -35.923 -55.191 -21.155 0.41 51.16  ? 806  THR A CB  1 
ATOM   3982 O  OG1 . THR A 1 543 ? -36.779 -54.611 -22.140 0.41 51.68  ? 806  THR A OG1 1 
ATOM   3983 C  CG2 . THR A 1 543 ? -35.919 -54.337 -19.905 0.41 54.45  ? 806  THR A CG2 1 
ATOM   3984 N  N   . GLU A 1 544 ? -34.257 -55.880 -24.168 0.41 39.58  ? 807  GLU A N   1 
ATOM   3985 C  CA  . GLU A 1 544 ? -34.170 -56.775 -25.354 0.41 37.83  ? 807  GLU A CA  1 
ATOM   3986 C  C   . GLU A 1 544 ? -33.054 -57.816 -25.163 0.41 37.31  ? 807  GLU A C   1 
ATOM   3987 O  O   . GLU A 1 544 ? -32.108 -57.567 -24.384 0.41 33.20  ? 807  GLU A O   1 
ATOM   3988 C  CB  . GLU A 1 544 ? -33.931 -55.976 -26.634 0.41 37.96  ? 807  GLU A CB  1 
ATOM   3989 C  CG  . GLU A 1 544 ? -33.935 -56.842 -27.878 0.41 39.82  ? 807  GLU A CG  1 
ATOM   3990 C  CD  . GLU A 1 544 ? -34.116 -56.099 -29.190 0.41 43.22  ? 807  GLU A CD  1 
ATOM   3991 O  OE1 . GLU A 1 544 ? -35.118 -56.382 -29.897 0.41 37.87  ? 807  GLU A OE1 1 
ATOM   3992 O  OE2 . GLU A 1 544 ? -33.252 -55.240 -29.501 0.41 45.95  ? 807  GLU A OE2 1 
ATOM   3993 N  N   . ASP A 1 545 ? -33.190 -58.961 -25.837 0.41 36.79  ? 808  ASP A N   1 
ATOM   3994 C  CA  . ASP A 1 545 ? -32.134 -59.994 -26.006 0.41 38.37  ? 808  ASP A CA  1 
ATOM   3995 C  C   . ASP A 1 545 ? -30.786 -59.288 -26.227 0.41 36.24  ? 808  ASP A C   1 
ATOM   3996 O  O   . ASP A 1 545 ? -30.745 -58.352 -27.054 0.41 32.65  ? 808  ASP A O   1 
ATOM   3997 C  CB  . ASP A 1 545 ? -32.492 -60.915 -27.175 0.41 41.41  ? 808  ASP A CB  1 
ATOM   3998 C  CG  . ASP A 1 545 ? -31.729 -62.228 -27.207 0.41 44.94  ? 808  ASP A CG  1 
ATOM   3999 O  OD1 . ASP A 1 545 ? -30.557 -62.234 -26.769 0.41 44.49  ? 808  ASP A OD1 1 
ATOM   4000 O  OD2 . ASP A 1 545 ? -32.315 -63.240 -27.683 0.41 48.18  ? 808  ASP A OD2 1 
ATOM   4001 N  N   . MET A 1 546 ? -29.729 -59.689 -25.510 0.41 35.90  ? 809  MET A N   1 
ATOM   4002 C  CA  . MET A 1 546 ? -28.378 -59.075 -25.676 0.41 35.26  ? 809  MET A CA  1 
ATOM   4003 C  C   . MET A 1 546 ? -27.783 -59.527 -27.017 0.41 32.51  ? 809  MET A C   1 
ATOM   4004 O  O   . MET A 1 546 ? -27.085 -58.710 -27.642 0.41 30.21  ? 809  MET A O   1 
ATOM   4005 C  CB  . MET A 1 546 ? -27.427 -59.418 -24.525 0.41 36.75  ? 809  MET A CB  1 
ATOM   4006 C  CG  . MET A 1 546 ? -27.368 -58.359 -23.429 0.41 36.67  ? 809  MET A CG  1 
ATOM   4007 S  SD  . MET A 1 546 ? -26.881 -56.704 -24.017 0.41 44.40  ? 809  MET A SD  1 
ATOM   4008 C  CE  . MET A 1 546 ? -28.438 -55.835 -23.850 0.41 40.25  ? 809  MET A CE  1 
ATOM   4009 N  N   . LEU A 1 547 ? -28.082 -60.750 -27.477 0.41 30.37  ? 810  LEU A N   1 
ATOM   4010 C  CA  . LEU A 1 547 ? -27.609 -61.227 -28.809 0.41 31.23  ? 810  LEU A CA  1 
ATOM   4011 C  C   . LEU A 1 547 ? -28.194 -60.338 -29.913 0.41 29.93  ? 810  LEU A C   1 
ATOM   4012 O  O   . LEU A 1 547 ? -27.453 -60.044 -30.865 0.41 28.79  ? 810  LEU A O   1 
ATOM   4013 C  CB  . LEU A 1 547 ? -27.977 -62.693 -29.044 0.41 32.57  ? 810  LEU A CB  1 
ATOM   4014 C  CG  . LEU A 1 547 ? -27.295 -63.352 -30.245 0.41 33.40  ? 810  LEU A CG  1 
ATOM   4015 C  CD1 . LEU A 1 547 ? -25.775 -63.357 -30.099 0.41 34.32  ? 810  LEU A CD1 1 
ATOM   4016 C  CD2 . LEU A 1 547 ? -27.794 -64.773 -30.434 0.41 34.23  ? 810  LEU A CD2 1 
ATOM   4017 N  N   . THR A 1 548 ? -29.466 -59.938 -29.804 1.00 28.33  ? 811  THR A N   1 
ATOM   4018 C  CA  . THR A 1 548 ? -30.099 -59.064 -30.826 1.00 29.30  ? 811  THR A CA  1 
ATOM   4019 C  C   . THR A 1 548 ? -29.389 -57.708 -30.837 1.00 29.10  ? 811  THR A C   1 
ATOM   4020 O  O   . THR A 1 548 ? -29.119 -57.184 -31.896 1.00 26.84  ? 811  THR A O   1 
ATOM   4021 C  CB  . THR A 1 548 ? -31.616 -58.914 -30.580 1.00 30.64  ? 811  THR A CB  1 
ATOM   4022 O  OG1 . THR A 1 548 ? -32.158 -60.240 -30.635 1.00 33.29  ? 811  THR A OG1 1 
ATOM   4023 C  CG2 . THR A 1 548 ? -32.271 -58.043 -31.626 1.00 32.49  ? 811  THR A CG2 1 
ATOM   4024 N  N   . VAL A 1 549 ? -29.136 -57.144 -29.670 1.00 27.51  ? 812  VAL A N   1 
ATOM   4025 C  CA  . VAL A 1 549 ? -28.409 -55.863 -29.565 1.00 28.14  ? 812  VAL A CA  1 
ATOM   4026 C  C   . VAL A 1 549 ? -26.976 -56.040 -30.077 1.00 26.52  ? 812  VAL A C   1 
ATOM   4027 O  O   . VAL A 1 549 ? -26.488 -55.136 -30.784 1.00 26.40  ? 812  VAL A O   1 
ATOM   4028 C  CB  . VAL A 1 549 ? -28.392 -55.344 -28.118 1.00 31.08  ? 812  VAL A CB  1 
ATOM   4029 C  CG1 . VAL A 1 549 ? -27.628 -54.016 -28.060 1.00 32.18  ? 812  VAL A CG1 1 
ATOM   4030 C  CG2 . VAL A 1 549 ? -29.818 -55.191 -27.579 1.00 36.33  ? 812  VAL A CG2 1 
ATOM   4031 N  N   . TRP A 1 550 ? -26.296 -57.140 -29.738 1.00 29.09  ? 813  TRP A N   1 
ATOM   4032 C  CA  . TRP A 1 550 ? -24.911 -57.382 -30.242 1.00 25.17  ? 813  TRP A CA  1 
ATOM   4033 C  C   . TRP A 1 550 ? -24.909 -57.316 -31.780 1.00 29.82  ? 813  TRP A C   1 
ATOM   4034 O  O   . TRP A 1 550 ? -24.046 -56.623 -32.384 1.00 29.84  ? 813  TRP A O   1 
ATOM   4035 C  CB  . TRP A 1 550 ? -24.342 -58.698 -29.688 1.00 24.28  ? 813  TRP A CB  1 
ATOM   4036 C  CG  . TRP A 1 550 ? -22.877 -58.852 -29.967 1.00 25.73  ? 813  TRP A CG  1 
ATOM   4037 C  CD1 . TRP A 1 550 ? -21.848 -58.631 -29.082 1.00 26.93  ? 813  TRP A CD1 1 
ATOM   4038 C  CD2 . TRP A 1 550 ? -22.261 -59.246 -31.199 1.00 24.95  ? 813  TRP A CD2 1 
ATOM   4039 N  NE1 . TRP A 1 550 ? -20.633 -58.874 -29.659 1.00 27.27  ? 813  TRP A NE1 1 
ATOM   4040 C  CE2 . TRP A 1 550 ? -20.851 -59.239 -30.982 1.00 27.58  ? 813  TRP A CE2 1 
ATOM   4041 C  CE3 . TRP A 1 550 ? -22.741 -59.664 -32.435 1.00 28.87  ? 813  TRP A CE3 1 
ATOM   4042 C  CZ2 . TRP A 1 550 ? -19.938 -59.616 -31.961 1.00 27.32  ? 813  TRP A CZ2 1 
ATOM   4043 C  CZ3 . TRP A 1 550 ? -21.837 -60.001 -33.424 1.00 26.31  ? 813  TRP A CZ3 1 
ATOM   4044 C  CH2 . TRP A 1 550 ? -20.451 -59.977 -33.195 1.00 26.28  ? 813  TRP A CH2 1 
ATOM   4045 N  N   . ASN A 1 551 ? -25.785 -58.103 -32.412 0.41 28.78  ? 814  ASN A N   1 
ATOM   4046 C  CA  . ASN A 1 551 ? -25.867 -58.216 -33.894 0.41 29.56  ? 814  ASN A CA  1 
ATOM   4047 C  C   . ASN A 1 551 ? -26.121 -56.831 -34.496 0.41 27.65  ? 814  ASN A C   1 
ATOM   4048 O  O   . ASN A 1 551 ? -25.534 -56.545 -35.543 0.41 27.98  ? 814  ASN A O   1 
ATOM   4049 C  CB  . ASN A 1 551 ? -26.937 -59.208 -34.366 0.41 30.78  ? 814  ASN A CB  1 
ATOM   4050 C  CG  . ASN A 1 551 ? -26.404 -60.613 -34.538 0.41 33.04  ? 814  ASN A CG  1 
ATOM   4051 O  OD1 . ASN A 1 551 ? -25.323 -60.815 -35.094 0.41 33.85  ? 814  ASN A OD1 1 
ATOM   4052 N  ND2 . ASN A 1 551 ? -27.174 -61.598 -34.099 0.41 36.10  ? 814  ASN A ND2 1 
ATOM   4053 N  N   . ARG A 1 552 ? -26.971 -56.014 -33.870 0.41 28.58  ? 815  ARG A N   1 
ATOM   4054 C  CA  . ARG A 1 552 ? -27.285 -54.652 -34.371 0.41 29.61  ? 815  ARG A CA  1 
ATOM   4055 C  C   . ARG A 1 552 ? -25.986 -53.831 -34.336 0.41 29.28  ? 815  ARG A C   1 
ATOM   4056 O  O   . ARG A 1 552 ? -25.535 -53.388 -35.424 0.41 27.31  ? 815  ARG A O   1 
ATOM   4057 C  CB  . ARG A 1 552 ? -28.414 -54.019 -33.551 0.41 31.27  ? 815  ARG A CB  1 
ATOM   4058 C  CG  . ARG A 1 552 ? -28.884 -52.673 -34.080 0.41 33.79  ? 815  ARG A CG  1 
ATOM   4059 C  CD  . ARG A 1 552 ? -29.776 -51.902 -33.119 0.41 37.44  ? 815  ARG A CD  1 
ATOM   4060 N  NE  . ARG A 1 552 ? -30.995 -52.635 -32.806 0.41 42.06  ? 815  ARG A NE  1 
ATOM   4061 C  CZ  . ARG A 1 552 ? -31.468 -52.877 -31.580 0.41 42.08  ? 815  ARG A CZ  1 
ATOM   4062 N  NH1 . ARG A 1 552 ? -30.848 -52.418 -30.506 0.41 39.39  ? 815  ARG A NH1 1 
ATOM   4063 N  NH2 . ARG A 1 552 ? -32.593 -53.561 -31.439 0.41 42.76  ? 815  ARG A NH2 1 
ATOM   4064 N  N   . VAL A 1 553 ? -25.384 -53.715 -33.145 1.00 28.58  ? 816  VAL A N   1 
ATOM   4065 C  CA  . VAL A 1 553 ? -24.201 -52.836 -32.870 1.00 29.27  ? 816  VAL A CA  1 
ATOM   4066 C  C   . VAL A 1 553 ? -22.984 -53.263 -33.707 1.00 27.41  ? 816  VAL A C   1 
ATOM   4067 O  O   . VAL A 1 553 ? -22.336 -52.389 -34.348 1.00 33.53  ? 816  VAL A O   1 
ATOM   4068 C  CB  . VAL A 1 553 ? -23.937 -52.825 -31.354 1.00 30.87  ? 816  VAL A CB  1 
ATOM   4069 C  CG1 . VAL A 1 553 ? -22.595 -52.185 -31.037 1.00 31.59  ? 816  VAL A CG1 1 
ATOM   4070 C  CG2 . VAL A 1 553 ? -25.063 -52.068 -30.679 1.00 29.95  ? 816  VAL A CG2 1 
ATOM   4071 N  N   . TRP A 1 554 ? -22.610 -54.538 -33.698 1.00 25.75  ? 817  TRP A N   1 
ATOM   4072 C  CA  . TRP A 1 554 ? -21.334 -55.013 -34.268 1.00 23.97  ? 817  TRP A CA  1 
ATOM   4073 C  C   . TRP A 1 554 ? -21.507 -55.386 -35.731 1.00 28.62  ? 817  TRP A C   1 
ATOM   4074 O  O   . TRP A 1 554 ? -20.505 -55.418 -36.382 1.00 26.87  ? 817  TRP A O   1 
ATOM   4075 C  CB  . TRP A 1 554 ? -20.761 -56.165 -33.434 1.00 27.07  ? 817  TRP A CB  1 
ATOM   4076 C  CG  . TRP A 1 554 ? -20.274 -55.705 -32.084 1.00 26.30  ? 817  TRP A CG  1 
ATOM   4077 C  CD1 . TRP A 1 554 ? -20.870 -55.852 -30.872 1.00 25.05  ? 817  TRP A CD1 1 
ATOM   4078 C  CD2 . TRP A 1 554 ? -19.076 -54.958 -31.856 1.00 24.19  ? 817  TRP A CD2 1 
ATOM   4079 N  NE1 . TRP A 1 554 ? -20.132 -55.243 -29.898 1.00 24.65  ? 817  TRP A NE1 1 
ATOM   4080 C  CE2 . TRP A 1 554 ? -19.003 -54.711 -30.471 1.00 23.81  ? 817  TRP A CE2 1 
ATOM   4081 C  CE3 . TRP A 1 554 ? -18.068 -54.492 -32.691 1.00 21.49  ? 817  TRP A CE3 1 
ATOM   4082 C  CZ2 . TRP A 1 554 ? -17.923 -54.039 -29.905 1.00 25.36  ? 817  TRP A CZ2 1 
ATOM   4083 C  CZ3 . TRP A 1 554 ? -16.994 -53.815 -32.124 1.00 25.55  ? 817  TRP A CZ3 1 
ATOM   4084 C  CH2 . TRP A 1 554 ? -16.955 -53.553 -30.753 1.00 22.01  ? 817  TRP A CH2 1 
ATOM   4085 N  N   . ILE A 1 555 ? -22.730 -55.710 -36.214 1.00 29.25  ? 818  ILE A N   1 
ATOM   4086 C  CA  . ILE A 1 555 ? -22.917 -56.185 -37.614 1.00 30.85  ? 818  ILE A CA  1 
ATOM   4087 C  C   . ILE A 1 555 ? -23.759 -55.155 -38.393 1.00 33.36  ? 818  ILE A C   1 
ATOM   4088 O  O   . ILE A 1 555 ? -23.196 -54.505 -39.280 1.00 29.66  ? 818  ILE A O   1 
ATOM   4089 C  CB  . ILE A 1 555 ? -23.537 -57.597 -37.709 1.00 32.10  ? 818  ILE A CB  1 
ATOM   4090 C  CG1 . ILE A 1 555 ? -22.804 -58.637 -36.857 1.00 32.48  ? 818  ILE A CG1 1 
ATOM   4091 C  CG2 . ILE A 1 555 ? -23.610 -58.049 -39.172 1.00 33.10  ? 818  ILE A CG2 1 
ATOM   4092 C  CD1 . ILE A 1 555 ? -21.396 -58.762 -37.200 1.00 35.30  ? 818  ILE A CD1 1 
ATOM   4093 N  N   . GLN A 1 556 ? -25.055 -54.994 -38.053 0.41 32.80  ? 819  GLN A N   1 
ATOM   4094 C  CA  . GLN A 1 556 ? -26.057 -54.170 -38.805 0.41 32.79  ? 819  GLN A CA  1 
ATOM   4095 C  C   . GLN A 1 556 ? -25.584 -52.715 -38.939 0.41 32.51  ? 819  GLN A C   1 
ATOM   4096 O  O   . GLN A 1 556 ? -25.437 -52.251 -40.082 0.41 32.15  ? 819  GLN A O   1 
ATOM   4097 C  CB  . GLN A 1 556 ? -27.436 -54.180 -38.126 0.41 33.34  ? 819  GLN A CB  1 
ATOM   4098 C  CG  . GLN A 1 556 ? -28.504 -53.332 -38.829 0.41 33.52  ? 819  GLN A CG  1 
ATOM   4099 C  CD  . GLN A 1 556 ? -29.781 -53.110 -38.039 0.41 35.50  ? 819  GLN A CD  1 
ATOM   4100 O  OE1 . GLN A 1 556 ? -30.443 -52.075 -38.169 0.41 34.56  ? 819  GLN A OE1 1 
ATOM   4101 N  NE2 . GLN A 1 556 ? -30.152 -54.076 -37.206 0.41 34.50  ? 819  GLN A NE2 1 
ATOM   4102 N  N   . GLU A 1 557 ? -25.409 -52.007 -37.819 0.41 31.49  ? 820  GLU A N   1 
ATOM   4103 C  CA  . GLU A 1 557 ? -25.120 -50.544 -37.798 0.41 33.01  ? 820  GLU A CA  1 
ATOM   4104 C  C   . GLU A 1 557 ? -23.646 -50.284 -38.156 0.41 31.77  ? 820  GLU A C   1 
ATOM   4105 O  O   . GLU A 1 557 ? -23.311 -49.128 -38.498 0.41 31.37  ? 820  GLU A O   1 
ATOM   4106 C  CB  . GLU A 1 557 ? -25.445 -49.933 -36.428 0.41 33.89  ? 820  GLU A CB  1 
ATOM   4107 C  CG  . GLU A 1 557 ? -26.915 -49.633 -36.203 0.41 37.36  ? 820  GLU A CG  1 
ATOM   4108 C  CD  . GLU A 1 557 ? -27.259 -49.021 -34.846 0.41 40.64  ? 820  GLU A CD  1 
ATOM   4109 O  OE1 . GLU A 1 557 ? -26.398 -49.043 -33.922 0.41 41.23  ? 820  GLU A OE1 1 
ATOM   4110 O  OE2 . GLU A 1 557 ? -28.401 -48.540 -34.702 0.41 45.98  ? 820  GLU A OE2 1 
ATOM   4111 N  N   . ASN A 1 558 ? -22.798 -51.312 -38.120 1.00 31.49  ? 821  ASN A N   1 
ATOM   4112 C  CA  . ASN A 1 558 ? -21.317 -51.119 -38.108 1.00 31.61  ? 821  ASN A CA  1 
ATOM   4113 C  C   . ASN A 1 558 ? -20.833 -50.782 -39.514 1.00 28.79  ? 821  ASN A C   1 
ATOM   4114 O  O   . ASN A 1 558 ? -20.765 -51.662 -40.359 1.00 28.00  ? 821  ASN A O   1 
ATOM   4115 C  CB  . ASN A 1 558 ? -20.659 -52.390 -37.590 1.00 30.26  ? 821  ASN A CB  1 
ATOM   4116 C  CG  . ASN A 1 558 ? -19.139 -52.357 -37.506 1.00 30.11  ? 821  ASN A CG  1 
ATOM   4117 O  OD1 . ASN A 1 558 ? -18.504 -51.384 -37.899 1.00 30.45  ? 821  ASN A OD1 1 
ATOM   4118 N  ND2 . ASN A 1 558 ? -18.557 -53.435 -36.980 1.00 26.49  ? 821  ASN A ND2 1 
ATOM   4119 N  N   . PRO A 1 559 ? -20.421 -49.526 -39.798 0.41 30.07  ? 822  PRO A N   1 
ATOM   4120 C  CA  . PRO A 1 559 ? -20.060 -49.135 -41.161 0.41 31.41  ? 822  PRO A CA  1 
ATOM   4121 C  C   . PRO A 1 559 ? -18.754 -49.797 -41.626 0.41 32.23  ? 822  PRO A C   1 
ATOM   4122 O  O   . PRO A 1 559 ? -18.505 -49.840 -42.819 0.41 32.92  ? 822  PRO A O   1 
ATOM   4123 C  CB  . PRO A 1 559 ? -19.919 -47.612 -41.072 0.41 31.64  ? 822  PRO A CB  1 
ATOM   4124 C  CG  . PRO A 1 559 ? -19.511 -47.363 -39.637 0.41 31.90  ? 822  PRO A CG  1 
ATOM   4125 C  CD  . PRO A 1 559 ? -20.216 -48.438 -38.831 0.41 31.70  ? 822  PRO A CD  1 
ATOM   4126 N  N   . TRP A 1 560 ? -17.970 -50.352 -40.695 1.00 31.60  ? 823  TRP A N   1 
ATOM   4127 C  CA  . TRP A 1 560 ? -16.702 -51.038 -41.067 1.00 32.25  ? 823  TRP A CA  1 
ATOM   4128 C  C   . TRP A 1 560 ? -16.885 -52.537 -41.414 1.00 35.47  ? 823  TRP A C   1 
ATOM   4129 O  O   . TRP A 1 560 ? -15.872 -53.162 -41.751 1.00 39.57  ? 823  TRP A O   1 
ATOM   4130 C  CB  . TRP A 1 560 ? -15.686 -50.821 -39.947 1.00 32.71  ? 823  TRP A CB  1 
ATOM   4131 C  CG  . TRP A 1 560 ? -15.209 -49.410 -39.861 1.00 28.97  ? 823  TRP A CG  1 
ATOM   4132 C  CD1 . TRP A 1 560 ? -14.251 -48.807 -40.627 1.00 28.14  ? 823  TRP A CD1 1 
ATOM   4133 C  CD2 . TRP A 1 560 ? -15.705 -48.414 -38.969 1.00 30.45  ? 823  TRP A CD2 1 
ATOM   4134 N  NE1 . TRP A 1 560 ? -14.101 -47.503 -40.236 1.00 32.95  ? 823  TRP A NE1 1 
ATOM   4135 C  CE2 . TRP A 1 560 ? -14.965 -47.237 -39.210 1.00 29.22  ? 823  TRP A CE2 1 
ATOM   4136 C  CE3 . TRP A 1 560 ? -16.650 -48.423 -37.953 1.00 28.48  ? 823  TRP A CE3 1 
ATOM   4137 C  CZ2 . TRP A 1 560 ? -15.195 -46.066 -38.503 1.00 31.54  ? 823  TRP A CZ2 1 
ATOM   4138 C  CZ3 . TRP A 1 560 ? -16.874 -47.270 -37.253 1.00 30.95  ? 823  TRP A CZ3 1 
ATOM   4139 C  CH2 . TRP A 1 560 ? -16.144 -46.107 -37.510 1.00 29.56  ? 823  TRP A CH2 1 
ATOM   4140 N  N   . MET A 1 561 ? -18.111 -53.096 -41.330 1.00 35.82  ? 824  MET A N   1 
ATOM   4141 C  CA  . MET A 1 561 ? -18.449 -54.530 -41.578 1.00 33.68  ? 824  MET A CA  1 
ATOM   4142 C  C   . MET A 1 561 ? -19.289 -54.602 -42.871 1.00 35.75  ? 824  MET A C   1 
ATOM   4143 O  O   . MET A 1 561 ? -20.476 -54.162 -42.865 1.00 33.37  ? 824  MET A O   1 
ATOM   4144 C  CB  . MET A 1 561 ? -19.274 -55.051 -40.392 1.00 34.80  ? 824  MET A CB  1 
ATOM   4145 C  CG  . MET A 1 561 ? -19.565 -56.551 -40.389 1.00 36.13  ? 824  MET A CG  1 
ATOM   4146 S  SD  . MET A 1 561 ? -18.085 -57.421 -40.096 1.00 53.40  ? 824  MET A SD  1 
ATOM   4147 C  CE  . MET A 1 561 ? -17.973 -57.226 -38.312 1.00 54.48  ? 824  MET A CE  1 
ATOM   4148 N  N   . GLU A 1 562 ? -18.720 -55.071 -43.973 1.00 37.70  ? 825  GLU A N   1 
ATOM   4149 C  CA  . GLU A 1 562 ? -19.437 -55.112 -45.282 1.00 46.57  ? 825  GLU A CA  1 
ATOM   4150 C  C   . GLU A 1 562 ? -20.489 -56.241 -45.290 1.00 42.04  ? 825  GLU A C   1 
ATOM   4151 O  O   . GLU A 1 562 ? -21.618 -55.977 -45.709 1.00 43.11  ? 825  GLU A O   1 
ATOM   4152 C  CB  . GLU A 1 562 ? -18.465 -55.268 -46.450 1.00 55.40  ? 825  GLU A CB  1 
ATOM   4153 C  CG  . GLU A 1 562 ? -19.104 -55.068 -47.817 1.00 65.51  ? 825  GLU A CG  1 
ATOM   4154 C  CD  . GLU A 1 562 ? -18.111 -54.971 -48.975 1.00 86.20  ? 825  GLU A CD  1 
ATOM   4155 O  OE1 . GLU A 1 562 ? -18.573 -54.941 -50.146 1.00 90.39  ? 825  GLU A OE1 1 
ATOM   4156 O  OE2 . GLU A 1 562 ? -16.869 -54.910 -48.716 1.00 100.13 ? 825  GLU A OE2 1 
ATOM   4157 N  N   . ASP A 1 563 ? -20.133 -57.443 -44.855 1.00 36.39  ? 826  ASP A N   1 
ATOM   4158 C  CA  . ASP A 1 563 ? -21.035 -58.618 -44.822 1.00 38.63  ? 826  ASP A CA  1 
ATOM   4159 C  C   . ASP A 1 563 ? -21.951 -58.488 -43.602 1.00 36.35  ? 826  ASP A C   1 
ATOM   4160 O  O   . ASP A 1 563 ? -21.419 -58.457 -42.466 1.00 37.86  ? 826  ASP A O   1 
ATOM   4161 C  CB  . ASP A 1 563 ? -20.182 -59.879 -44.808 1.00 37.89  ? 826  ASP A CB  1 
ATOM   4162 C  CG  . ASP A 1 563 ? -20.927 -61.174 -44.565 1.00 41.28  ? 826  ASP A CG  1 
ATOM   4163 O  OD1 . ASP A 1 563 ? -22.162 -61.119 -44.421 1.00 39.42  ? 826  ASP A OD1 1 
ATOM   4164 O  OD2 . ASP A 1 563 ? -20.251 -62.195 -44.412 1.00 44.75  ? 826  ASP A OD2 1 
ATOM   4165 N  N   . LYS A 1 564 ? -23.263 -58.437 -43.824 1.00 34.32  ? 827  LYS A N   1 
ATOM   4166 C  CA  . LYS A 1 564 ? -24.276 -58.185 -42.779 1.00 32.96  ? 827  LYS A CA  1 
ATOM   4167 C  C   . LYS A 1 564 ? -24.943 -59.474 -42.288 1.00 31.22  ? 827  LYS A C   1 
ATOM   4168 O  O   . LYS A 1 564 ? -26.008 -59.401 -41.623 1.00 34.88  ? 827  LYS A O   1 
ATOM   4169 C  CB  . LYS A 1 564 ? -25.324 -57.175 -43.233 1.00 35.01  ? 827  LYS A CB  1 
ATOM   4170 C  CG  . LYS A 1 564 ? -24.763 -55.833 -43.660 1.00 40.74  ? 827  LYS A CG  1 
ATOM   4171 C  CD  . LYS A 1 564 ? -23.861 -55.202 -42.622 1.00 36.30  ? 827  LYS A CD  1 
ATOM   4172 C  CE  . LYS A 1 564 ? -23.633 -53.739 -42.904 1.00 34.20  ? 827  LYS A CE  1 
ATOM   4173 N  NZ  . LYS A 1 564 ? -22.828 -53.103 -41.829 1.00 34.56  ? 827  LYS A NZ  1 
ATOM   4174 N  N   . THR A 1 565 ? -24.327 -60.622 -42.566 0.41 32.63  ? 828  THR A N   1 
ATOM   4175 C  CA  . THR A 1 565 ? -24.844 -61.957 -42.172 0.41 34.53  ? 828  THR A CA  1 
ATOM   4176 C  C   . THR A 1 565 ? -24.881 -62.030 -40.648 0.41 36.47  ? 828  THR A C   1 
ATOM   4177 O  O   . THR A 1 565 ? -23.841 -61.920 -40.002 0.41 32.98  ? 828  THR A O   1 
ATOM   4178 C  CB  . THR A 1 565 ? -24.007 -63.071 -42.804 0.41 36.26  ? 828  THR A CB  1 
ATOM   4179 O  OG1 . THR A 1 565 ? -24.191 -62.939 -44.213 0.41 34.62  ? 828  THR A OG1 1 
ATOM   4180 C  CG2 . THR A 1 565 ? -24.401 -64.455 -42.336 0.41 37.62  ? 828  THR A CG2 1 
ATOM   4181 N  N   . PRO A 1 566 ? -26.072 -62.204 -40.025 0.41 39.55  ? 829  PRO A N   1 
ATOM   4182 C  CA  . PRO A 1 566 ? -26.187 -62.130 -38.572 0.41 38.94  ? 829  PRO A CA  1 
ATOM   4183 C  C   . PRO A 1 566 ? -25.506 -63.317 -37.884 0.41 38.91  ? 829  PRO A C   1 
ATOM   4184 O  O   . PRO A 1 566 ? -25.235 -64.311 -38.533 0.41 35.43  ? 829  PRO A O   1 
ATOM   4185 C  CB  . PRO A 1 566 ? -27.706 -62.137 -38.316 0.41 41.89  ? 829  PRO A CB  1 
ATOM   4186 C  CG  . PRO A 1 566 ? -28.336 -61.855 -39.668 0.41 40.47  ? 829  PRO A CG  1 
ATOM   4187 C  CD  . PRO A 1 566 ? -27.374 -62.451 -40.668 0.41 40.04  ? 829  PRO A CD  1 
ATOM   4188 N  N   . VAL A 1 567 ? -25.235 -63.163 -36.588 0.41 38.40  ? 830  VAL A N   1 
ATOM   4189 C  CA  . VAL A 1 567 ? -24.768 -64.247 -35.678 0.41 39.57  ? 830  VAL A CA  1 
ATOM   4190 C  C   . VAL A 1 567 ? -26.000 -64.825 -34.962 0.41 38.52  ? 830  VAL A C   1 
ATOM   4191 O  O   . VAL A 1 567 ? -26.839 -64.035 -34.496 0.41 40.05  ? 830  VAL A O   1 
ATOM   4192 C  CB  . VAL A 1 567 ? -23.719 -63.692 -34.694 0.41 41.17  ? 830  VAL A CB  1 
ATOM   4193 C  CG1 . VAL A 1 567 ? -23.461 -64.637 -33.541 0.41 43.39  ? 830  VAL A CG1 1 
ATOM   4194 C  CG2 . VAL A 1 567 ? -22.424 -63.338 -35.402 0.41 41.46  ? 830  VAL A CG2 1 
ATOM   4195 N  N   . GLU A 1 568 ? -26.089 -66.152 -34.864 0.41 40.63  ? 831  GLU A N   1 
ATOM   4196 C  CA  . GLU A 1 568 ? -27.276 -66.898 -34.358 0.41 40.61  ? 831  GLU A CA  1 
ATOM   4197 C  C   . GLU A 1 568 ? -26.916 -67.639 -33.062 0.41 40.22  ? 831  GLU A C   1 
ATOM   4198 O  O   . GLU A 1 568 ? -27.731 -68.461 -32.603 0.41 37.28  ? 831  GLU A O   1 
ATOM   4199 C  CB  . GLU A 1 568 ? -27.747 -67.900 -35.416 0.41 42.92  ? 831  GLU A CB  1 
ATOM   4200 C  CG  . GLU A 1 568 ? -28.073 -67.275 -36.767 0.41 44.48  ? 831  GLU A CG  1 
ATOM   4201 C  CD  . GLU A 1 568 ? -29.480 -66.719 -36.910 0.41 46.68  ? 831  GLU A CD  1 
ATOM   4202 O  OE1 . GLU A 1 568 ? -30.415 -67.332 -36.359 0.41 49.47  ? 831  GLU A OE1 1 
ATOM   4203 O  OE2 . GLU A 1 568 ? -29.641 -65.676 -37.581 0.41 49.60  ? 831  GLU A OE2 1 
ATOM   4204 N  N   . SER A 1 569 ? -25.736 -67.373 -32.490 0.41 36.88  ? 832  SER A N   1 
ATOM   4205 C  CA  . SER A 1 569 ? -25.275 -67.990 -31.221 0.41 35.50  ? 832  SER A CA  1 
ATOM   4206 C  C   . SER A 1 569 ? -24.035 -67.266 -30.693 0.41 36.21  ? 832  SER A C   1 
ATOM   4207 O  O   . SER A 1 569 ? -23.152 -66.887 -31.497 0.41 34.24  ? 832  SER A O   1 
ATOM   4208 C  CB  . SER A 1 569 ? -25.002 -69.453 -31.396 0.41 36.37  ? 832  SER A CB  1 
ATOM   4209 O  OG  . SER A 1 569 ? -24.204 -69.675 -32.545 0.41 36.18  ? 832  SER A OG  1 
ATOM   4210 N  N   . TRP A 1 570 ? -23.975 -67.095 -29.377 0.41 34.60  ? 833  TRP A N   1 
ATOM   4211 C  CA  . TRP A 1 570 ? -22.831 -66.441 -28.699 0.41 34.73  ? 833  TRP A CA  1 
ATOM   4212 C  C   . TRP A 1 570 ? -21.532 -67.200 -29.006 0.41 35.66  ? 833  TRP A C   1 
ATOM   4213 O  O   . TRP A 1 570 ? -20.497 -66.541 -29.114 0.41 34.02  ? 833  TRP A O   1 
ATOM   4214 C  CB  . TRP A 1 570 ? -23.122 -66.293 -27.202 0.41 32.81  ? 833  TRP A CB  1 
ATOM   4215 C  CG  . TRP A 1 570 ? -23.991 -65.113 -26.904 0.41 33.14  ? 833  TRP A CG  1 
ATOM   4216 C  CD1 . TRP A 1 570 ? -25.350 -65.099 -26.794 0.41 32.27  ? 833  TRP A CD1 1 
ATOM   4217 C  CD2 . TRP A 1 570 ? -23.558 -63.751 -26.717 0.41 33.01  ? 833  TRP A CD2 1 
ATOM   4218 N  NE1 . TRP A 1 570 ? -25.791 -63.829 -26.540 0.41 33.66  ? 833  TRP A NE1 1 
ATOM   4219 C  CE2 . TRP A 1 570 ? -24.717 -62.982 -26.479 0.41 31.73  ? 833  TRP A CE2 1 
ATOM   4220 C  CE3 . TRP A 1 570 ? -22.310 -63.109 -26.710 0.41 31.80  ? 833  TRP A CE3 1 
ATOM   4221 C  CZ2 . TRP A 1 570 ? -24.661 -61.610 -26.237 0.41 32.45  ? 833  TRP A CZ2 1 
ATOM   4222 C  CZ3 . TRP A 1 570 ? -22.256 -61.752 -26.471 0.41 31.12  ? 833  TRP A CZ3 1 
ATOM   4223 C  CH2 . TRP A 1 570 ? -23.420 -61.013 -26.247 0.41 32.16  ? 833  TRP A CH2 1 
ATOM   4224 N  N   . GLU A 1 571 ? -21.575 -68.514 -29.235 0.41 37.06  ? 834  GLU A N   1 
ATOM   4225 C  CA  . GLU A 1 571 ? -20.351 -69.320 -29.515 0.41 39.63  ? 834  GLU A CA  1 
ATOM   4226 C  C   . GLU A 1 571 ? -19.732 -68.928 -30.869 0.41 37.57  ? 834  GLU A C   1 
ATOM   4227 O  O   . GLU A 1 571 ? -18.553 -69.268 -31.072 0.41 40.27  ? 834  GLU A O   1 
ATOM   4228 C  CB  . GLU A 1 571 ? -20.651 -70.820 -29.413 0.41 44.86  ? 834  GLU A CB  1 
ATOM   4229 C  CG  . GLU A 1 571 ? -20.969 -71.265 -27.988 0.41 49.71  ? 834  GLU A CG  1 
ATOM   4230 C  CD  . GLU A 1 571 ? -21.109 -72.769 -27.755 0.41 55.25  ? 834  GLU A CD  1 
ATOM   4231 O  OE1 . GLU A 1 571 ? -20.351 -73.550 -28.387 0.41 59.47  ? 834  GLU A OE1 1 
ATOM   4232 O  OE2 . GLU A 1 571 ? -21.975 -73.164 -26.931 0.41 52.07  ? 834  GLU A OE2 1 
ATOM   4233 N  N   . GLU A 1 572 ? -20.460 -68.217 -31.738 0.41 35.57  ? 835  GLU A N   1 
ATOM   4234 C  CA  . GLU A 1 572 ? -19.926 -67.600 -32.994 0.41 36.69  ? 835  GLU A CA  1 
ATOM   4235 C  C   . GLU A 1 572 ? -19.196 -66.273 -32.706 0.41 32.52  ? 835  GLU A C   1 
ATOM   4236 O  O   . GLU A 1 572 ? -18.679 -65.654 -33.666 0.41 28.94  ? 835  GLU A O   1 
ATOM   4237 C  CB  . GLU A 1 572 ? -21.043 -67.255 -33.984 0.41 37.91  ? 835  GLU A CB  1 
ATOM   4238 C  CG  . GLU A 1 572 ? -21.924 -68.422 -34.399 0.41 41.26  ? 835  GLU A CG  1 
ATOM   4239 C  CD  . GLU A 1 572 ? -23.144 -68.004 -35.218 0.41 43.65  ? 835  GLU A CD  1 
ATOM   4240 O  OE1 . GLU A 1 572 ? -23.042 -67.010 -35.979 0.41 42.73  ? 835  GLU A OE1 1 
ATOM   4241 O  OE2 . GLU A 1 572 ? -24.201 -68.666 -35.098 0.41 47.65  ? 835  GLU A OE2 1 
ATOM   4242 N  N   . ILE A 1 573 ? -19.219 -65.801 -31.459 0.41 29.51  ? 836  ILE A N   1 
ATOM   4243 C  CA  . ILE A 1 573 ? -18.578 -64.516 -31.053 0.41 30.15  ? 836  ILE A CA  1 
ATOM   4244 C  C   . ILE A 1 573 ? -17.258 -64.862 -30.367 0.41 29.18  ? 836  ILE A C   1 
ATOM   4245 O  O   . ILE A 1 573 ? -17.250 -65.544 -29.346 0.41 28.85  ? 836  ILE A O   1 
ATOM   4246 C  CB  . ILE A 1 573 ? -19.531 -63.683 -30.178 0.41 29.81  ? 836  ILE A CB  1 
ATOM   4247 C  CG1 . ILE A 1 573 ? -20.828 -63.376 -30.928 0.41 28.87  ? 836  ILE A CG1 1 
ATOM   4248 C  CG2 . ILE A 1 573 ? -18.842 -62.415 -29.703 0.41 31.56  ? 836  ILE A CG2 1 
ATOM   4249 C  CD1 . ILE A 1 573 ? -21.927 -62.796 -30.069 0.41 29.42  ? 836  ILE A CD1 1 
ATOM   4250 N  N   . PRO A 1 574 ? -16.106 -64.438 -30.931 1.00 28.01  ? 837  PRO A N   1 
ATOM   4251 C  CA  . PRO A 1 574 ? -14.797 -64.904 -30.449 1.00 26.76  ? 837  PRO A CA  1 
ATOM   4252 C  C   . PRO A 1 574 ? -14.315 -64.239 -29.143 1.00 25.39  ? 837  PRO A C   1 
ATOM   4253 O  O   . PRO A 1 574 ? -14.846 -63.193 -28.730 1.00 22.94  ? 837  PRO A O   1 
ATOM   4254 C  CB  . PRO A 1 574 ? -13.866 -64.464 -31.578 1.00 28.77  ? 837  PRO A CB  1 
ATOM   4255 C  CG  . PRO A 1 574 ? -14.523 -63.170 -32.035 1.00 32.81  ? 837  PRO A CG  1 
ATOM   4256 C  CD  . PRO A 1 574 ? -16.015 -63.449 -32.006 1.00 30.08  ? 837  PRO A CD  1 
ATOM   4257 N  N   . TYR A 1 575 ? -13.293 -64.832 -28.538 1.00 23.96  ? 838  TYR A N   1 
ATOM   4258 C  CA  . TYR A 1 575 ? -12.507 -64.219 -27.444 1.00 23.04  ? 838  TYR A CA  1 
ATOM   4259 C  C   . TYR A 1 575 ? -11.126 -63.778 -27.956 1.00 25.54  ? 838  TYR A C   1 
ATOM   4260 O  O   . TYR A 1 575 ? -10.703 -64.231 -29.042 1.00 24.73  ? 838  TYR A O   1 
ATOM   4261 C  CB  . TYR A 1 575 ? -12.283 -65.314 -26.413 1.00 25.55  ? 838  TYR A CB  1 
ATOM   4262 C  CG  . TYR A 1 575 ? -13.513 -65.824 -25.705 1.00 25.13  ? 838  TYR A CG  1 
ATOM   4263 C  CD1 . TYR A 1 575 ? -14.194 -65.039 -24.781 1.00 21.25  ? 838  TYR A CD1 1 
ATOM   4264 C  CD2 . TYR A 1 575 ? -13.986 -67.104 -25.925 1.00 30.75  ? 838  TYR A CD2 1 
ATOM   4265 C  CE1 . TYR A 1 575 ? -15.274 -65.536 -24.068 1.00 23.79  ? 838  TYR A CE1 1 
ATOM   4266 C  CE2 . TYR A 1 575 ? -15.058 -67.612 -25.212 1.00 31.11  ? 838  TYR A CE2 1 
ATOM   4267 C  CZ  . TYR A 1 575 ? -15.744 -66.802 -24.314 1.00 29.91  ? 838  TYR A CZ  1 
ATOM   4268 O  OH  . TYR A 1 575 ? -16.835 -67.271 -23.631 1.00 31.48  ? 838  TYR A OH  1 
ATOM   4269 N  N   . LEU A 1 576 ? -10.427 -62.926 -27.195 0.41 23.14  ? 839  LEU A N   1 
ATOM   4270 C  CA  . LEU A 1 576 ? -8.973  -62.676 -27.384 0.41 23.22  ? 839  LEU A CA  1 
ATOM   4271 C  C   . LEU A 1 576 ? -8.261  -64.024 -27.248 0.41 22.34  ? 839  LEU A C   1 
ATOM   4272 O  O   . LEU A 1 576 ? -8.833  -64.908 -26.597 0.41 22.06  ? 839  LEU A O   1 
ATOM   4273 C  CB  . LEU A 1 576 ? -8.462  -61.685 -26.324 0.41 23.96  ? 839  LEU A CB  1 
ATOM   4274 C  CG  . LEU A 1 576 ? -9.142  -60.316 -26.273 0.41 22.98  ? 839  LEU A CG  1 
ATOM   4275 C  CD1 . LEU A 1 576 ? -8.517  -59.428 -25.208 0.41 23.66  ? 839  LEU A CD1 1 
ATOM   4276 C  CD2 . LEU A 1 576 ? -9.076  -59.627 -27.621 0.41 25.56  ? 839  LEU A CD2 1 
ATOM   4277 N  N   . GLY A 1 577 ? -7.056  -64.173 -27.810 1.00 22.14  ? 840  GLY A N   1 
ATOM   4278 C  CA  . GLY A 1 577 ? -6.194  -65.331 -27.481 1.00 21.60  ? 840  GLY A CA  1 
ATOM   4279 C  C   . GLY A 1 577 ? -6.100  -65.503 -25.949 1.00 21.18  ? 840  GLY A C   1 
ATOM   4280 O  O   . GLY A 1 577 ? -6.207  -64.534 -25.204 1.00 23.14  ? 840  GLY A O   1 
ATOM   4281 N  N   . LYS A 1 578 ? -5.911  -66.738 -25.505 0.41 20.39  ? 841  LYS A N   1 
ATOM   4282 C  CA  . LYS A 1 578 ? -5.820  -67.095 -24.064 0.41 20.57  ? 841  LYS A CA  1 
ATOM   4283 C  C   . LYS A 1 578 ? -4.668  -66.333 -23.392 0.41 20.07  ? 841  LYS A C   1 
ATOM   4284 O  O   . LYS A 1 578 ? -4.830  -65.914 -22.237 0.41 18.21  ? 841  LYS A O   1 
ATOM   4285 C  CB  . LYS A 1 578 ? -5.622  -68.597 -23.930 0.41 21.02  ? 841  LYS A CB  1 
ATOM   4286 C  CG  . LYS A 1 578 ? -6.844  -69.439 -24.260 0.41 21.05  ? 841  LYS A CG  1 
ATOM   4287 C  CD  . LYS A 1 578 ? -6.697  -70.863 -23.762 0.41 22.73  ? 841  LYS A CD  1 
ATOM   4288 C  CE  . LYS A 1 578 ? -6.200  -71.840 -24.802 0.41 22.38  ? 841  LYS A CE  1 
ATOM   4289 N  NZ  . LYS A 1 578 ? -4.890  -71.458 -25.337 0.41 22.24  ? 841  LYS A NZ  1 
ATOM   4290 N  N   . ARG A 1 579 ? -3.545  -66.149 -24.083 0.41 20.28  ? 842  ARG A N   1 
ATOM   4291 C  CA  . ARG A 1 579 ? -2.373  -65.439 -23.509 0.41 21.17  ? 842  ARG A CA  1 
ATOM   4292 C  C   . ARG A 1 579 ? -2.676  -63.935 -23.432 0.41 21.85  ? 842  ARG A C   1 
ATOM   4293 O  O   . ARG A 1 579 ? -2.407  -63.327 -22.370 0.41 22.21  ? 842  ARG A O   1 
ATOM   4294 C  CB  . ARG A 1 579 ? -1.104  -65.753 -24.299 0.41 20.15  ? 842  ARG A CB  1 
ATOM   4295 C  CG  . ARG A 1 579 ? 0.146   -65.248 -23.599 0.41 20.51  ? 842  ARG A CG  1 
ATOM   4296 C  CD  . ARG A 1 579 ? 1.413   -65.447 -24.408 0.41 20.16  ? 842  ARG A CD  1 
ATOM   4297 N  NE  . ARG A 1 579 ? 1.753   -66.860 -24.480 0.41 20.75  ? 842  ARG A NE  1 
ATOM   4298 C  CZ  . ARG A 1 579 ? 2.466   -67.537 -23.595 0.41 18.94  ? 842  ARG A CZ  1 
ATOM   4299 N  NH1 . ARG A 1 579 ? 2.708   -68.814 -23.817 0.41 19.48  ? 842  ARG A NH1 1 
ATOM   4300 N  NH2 . ARG A 1 579 ? 2.967   -66.954 -22.520 0.41 20.02  ? 842  ARG A NH2 1 
ATOM   4301 N  N   . GLU A 1 580 ? -3.248  -63.363 -24.487 0.41 23.35  ? 843  GLU A N   1 
ATOM   4302 C  CA  . GLU A 1 580 ? -3.680  -61.935 -24.522 0.41 24.38  ? 843  GLU A CA  1 
ATOM   4303 C  C   . GLU A 1 580 ? -4.678  -61.630 -23.400 0.41 22.52  ? 843  GLU A C   1 
ATOM   4304 O  O   . GLU A 1 580 ? -4.559  -60.563 -22.779 0.41 21.87  ? 843  GLU A O   1 
ATOM   4305 C  CB  . GLU A 1 580 ? -4.334  -61.586 -25.849 0.41 25.81  ? 843  GLU A CB  1 
ATOM   4306 C  CG  . GLU A 1 580 ? -3.457  -61.858 -27.041 0.41 30.01  ? 843  GLU A CG  1 
ATOM   4307 C  CD  . GLU A 1 580 ? -4.131  -61.444 -28.332 0.41 34.69  ? 843  GLU A CD  1 
ATOM   4308 O  OE1 . GLU A 1 580 ? -5.143  -62.100 -28.715 0.41 36.61  ? 843  GLU A OE1 1 
ATOM   4309 O  OE2 . GLU A 1 580 ? -3.694  -60.422 -28.907 0.41 36.16  ? 843  GLU A OE2 1 
ATOM   4310 N  N   . ASP A 1 581 ? -5.626  -62.529 -23.159 1.00 21.55  ? 844  ASP A N   1 
ATOM   4311 C  CA  . ASP A 1 581 ? -6.646  -62.365 -22.101 1.00 21.34  ? 844  ASP A CA  1 
ATOM   4312 C  C   . ASP A 1 581 ? -5.944  -62.269 -20.758 1.00 21.55  ? 844  ASP A C   1 
ATOM   4313 O  O   . ASP A 1 581 ? -6.264  -61.359 -19.973 1.00 19.77  ? 844  ASP A O   1 
ATOM   4314 C  CB  . ASP A 1 581 ? -7.676  -63.499 -22.213 1.00 23.31  ? 844  ASP A CB  1 
ATOM   4315 C  CG  . ASP A 1 581 ? -9.105  -63.197 -21.732 1.00 21.90  ? 844  ASP A CG  1 
ATOM   4316 O  OD1 . ASP A 1 581 ? -9.335  -62.167 -21.102 1.00 22.03  ? 844  ASP A OD1 1 
ATOM   4317 O  OD2 . ASP A 1 581 ? -9.986  -64.063 -21.982 1.00 20.38  ? 844  ASP A OD2 1 
ATOM   4318 N  N   . GLN A 1 582 ? -4.962  -63.141 -20.524 0.41 21.72  ? 845  GLN A N   1 
ATOM   4319 C  CA  . GLN A 1 582 ? -4.169  -63.155 -19.274 0.41 21.63  ? 845  GLN A CA  1 
ATOM   4320 C  C   . GLN A 1 582 ? -3.383  -61.836 -19.160 0.41 21.18  ? 845  GLN A C   1 
ATOM   4321 O  O   . GLN A 1 582 ? -3.401  -61.239 -18.063 0.41 19.59  ? 845  GLN A O   1 
ATOM   4322 C  CB  . GLN A 1 582 ? -3.311  -64.427 -19.242 0.41 24.07  ? 845  GLN A CB  1 
ATOM   4323 C  CG  . GLN A 1 582 ? -2.660  -64.690 -17.898 0.41 24.84  ? 845  GLN A CG  1 
ATOM   4324 C  CD  . GLN A 1 582 ? -1.874  -65.978 -17.892 0.41 26.03  ? 845  GLN A CD  1 
ATOM   4325 O  OE1 . GLN A 1 582 ? -0.841  -66.080 -18.541 0.41 29.16  ? 845  GLN A OE1 1 
ATOM   4326 N  NE2 . GLN A 1 582 ? -2.361  -66.970 -17.164 0.41 25.85  ? 845  GLN A NE2 1 
ATOM   4327 N  N   . TRP A 1 583 ? -2.732  -61.383 -20.244 1.00 19.90  ? 846  TRP A N   1 
ATOM   4328 C  CA  . TRP A 1 583 ? -1.982  -60.111 -20.264 1.00 17.87  ? 846  TRP A CA  1 
ATOM   4329 C  C   . TRP A 1 583 ? -2.898  -58.925 -19.826 1.00 23.33  ? 846  TRP A C   1 
ATOM   4330 O  O   . TRP A 1 583 ? -2.433  -58.039 -19.047 1.00 20.43  ? 846  TRP A O   1 
ATOM   4331 C  CB  . TRP A 1 583 ? -1.392  -59.822 -21.649 1.00 19.84  ? 846  TRP A CB  1 
ATOM   4332 C  CG  . TRP A 1 583 ? -0.190  -60.648 -22.017 1.00 20.90  ? 846  TRP A CG  1 
ATOM   4333 C  CD1 . TRP A 1 583 ? 0.652   -61.296 -21.158 1.00 23.64  ? 846  TRP A CD1 1 
ATOM   4334 C  CD2 . TRP A 1 583 ? 0.316   -60.917 -23.335 1.00 21.85  ? 846  TRP A CD2 1 
ATOM   4335 N  NE1 . TRP A 1 583 ? 1.633   -61.950 -21.855 1.00 25.64  ? 846  TRP A NE1 1 
ATOM   4336 C  CE2 . TRP A 1 583 ? 1.457   -61.730 -23.188 1.00 22.78  ? 846  TRP A CE2 1 
ATOM   4337 C  CE3 . TRP A 1 583 ? -0.059  -60.537 -24.618 1.00 24.97  ? 846  TRP A CE3 1 
ATOM   4338 C  CZ2 . TRP A 1 583 ? 2.221   -62.147 -24.267 1.00 25.20  ? 846  TRP A CZ2 1 
ATOM   4339 C  CZ3 . TRP A 1 583 ? 0.641   -61.024 -25.694 1.00 25.57  ? 846  TRP A CZ3 1 
ATOM   4340 C  CH2 . TRP A 1 583 ? 1.773   -61.823 -25.520 1.00 24.23  ? 846  TRP A CH2 1 
ATOM   4341 N  N   . CYS A 1 584 ? -4.176  -58.955 -20.251 1.00 18.56  ? 847  CYS A N   1 
ATOM   4342 C  CA  . CYS A 1 584 ? -5.128  -57.879 -19.959 1.00 18.79  ? 847  CYS A CA  1 
ATOM   4343 C  C   . CYS A 1 584 ? -5.885  -58.156 -18.648 1.00 20.41  ? 847  CYS A C   1 
ATOM   4344 O  O   . CYS A 1 584 ? -6.940  -57.477 -18.413 1.00 20.59  ? 847  CYS A O   1 
ATOM   4345 C  CB  . CYS A 1 584 ? -5.987  -57.666 -21.170 1.00 22.36  ? 847  CYS A CB  1 
ATOM   4346 S  SG  . CYS A 1 584 ? -5.046  -56.879 -22.485 1.00 21.57  ? 847  CYS A SG  1 
ATOM   4347 N  N   . GLY A 1 585 ? -5.410  -59.114 -17.833 1.00 20.97  ? 848  GLY A N   1 
ATOM   4348 C  CA  . GLY A 1 585 ? -5.773  -59.289 -16.409 1.00 21.29  ? 848  GLY A CA  1 
ATOM   4349 C  C   . GLY A 1 585 ? -6.702  -60.461 -16.129 1.00 21.76  ? 848  GLY A C   1 
ATOM   4350 O  O   . GLY A 1 585 ? -7.127  -60.598 -14.976 1.00 23.91  ? 848  GLY A O   1 
ATOM   4351 N  N   . SER A 1 586 ? -6.989  -61.345 -17.084 1.00 20.66  ? 849  SER A N   1 
ATOM   4352 C  CA  . SER A 1 586 ? -7.835  -62.561 -16.851 1.00 22.07  ? 849  SER A CA  1 
ATOM   4353 C  C   . SER A 1 586 ? -7.221  -63.417 -15.730 1.00 24.26  ? 849  SER A C   1 
ATOM   4354 O  O   . SER A 1 586 ? -5.980  -63.597 -15.703 1.00 22.09  ? 849  SER A O   1 
ATOM   4355 C  CB  . SER A 1 586 ? -7.929  -63.394 -18.089 1.00 20.36  ? 849  SER A CB  1 
ATOM   4356 O  OG  . SER A 1 586 ? -8.787  -64.504 -17.923 1.00 22.06  ? 849  SER A OG  1 
ATOM   4357 N  N   . LEU A 1 587 ? -8.084  -64.099 -14.999 1.00 22.44  ? 850  LEU A N   1 
ATOM   4358 C  CA  . LEU A 1 587 ? -7.701  -65.124 -14.004 1.00 24.49  ? 850  LEU A CA  1 
ATOM   4359 C  C   . LEU A 1 587 ? -7.717  -66.545 -14.556 1.00 25.76  ? 850  LEU A C   1 
ATOM   4360 O  O   . LEU A 1 587 ? -7.496  -67.477 -13.755 1.00 27.77  ? 850  LEU A O   1 
ATOM   4361 C  CB  . LEU A 1 587 ? -8.598  -64.998 -12.770 1.00 24.45  ? 850  LEU A CB  1 
ATOM   4362 C  CG  . LEU A 1 587 ? -8.548  -63.668 -12.044 1.00 25.10  ? 850  LEU A CG  1 
ATOM   4363 C  CD1 . LEU A 1 587 ? -9.253  -63.858 -10.691 1.00 30.10  ? 850  LEU A CD1 1 
ATOM   4364 C  CD2 . LEU A 1 587 ? -7.114  -63.141 -11.870 1.00 28.59  ? 850  LEU A CD2 1 
ATOM   4365 N  N   . ILE A 1 588 ? -7.935  -66.728 -15.870 0.41 22.72  ? 851  ILE A N   1 
ATOM   4366 C  CA  . ILE A 1 588 ? -7.910  -68.089 -16.480 0.41 23.10  ? 851  ILE A CA  1 
ATOM   4367 C  C   . ILE A 1 588 ? -6.576  -68.743 -16.097 0.41 26.52  ? 851  ILE A C   1 
ATOM   4368 O  O   . ILE A 1 588 ? -5.530  -68.051 -16.158 0.41 24.36  ? 851  ILE A O   1 
ATOM   4369 C  CB  . ILE A 1 588 ? -8.158  -68.110 -18.004 0.41 21.14  ? 851  ILE A CB  1 
ATOM   4370 C  CG1 . ILE A 1 588 ? -7.266  -67.133 -18.778 0.41 20.37  ? 851  ILE A CG1 1 
ATOM   4371 C  CG2 . ILE A 1 588 ? -9.631  -67.873 -18.303 0.41 18.89  ? 851  ILE A CG2 1 
ATOM   4372 C  CD1 . ILE A 1 588 ? -7.302  -67.333 -20.277 0.41 19.48  ? 851  ILE A CD1 1 
ATOM   4373 N  N   . GLY A 1 589 ? -6.637  -69.998 -15.644 1.00 28.85  ? 852  GLY A N   1 
ATOM   4374 C  CA  . GLY A 1 589 ? -5.450  -70.735 -15.192 1.00 31.04  ? 852  GLY A CA  1 
ATOM   4375 C  C   . GLY A 1 589 ? -5.342  -70.765 -13.673 1.00 35.74  ? 852  GLY A C   1 
ATOM   4376 O  O   . GLY A 1 589 ? -4.668  -71.634 -13.171 1.00 38.14  ? 852  GLY A O   1 
ATOM   4377 N  N   . LEU A 1 590 ? -5.995  -69.884 -12.923 1.00 30.85  ? 853  LEU A N   1 
ATOM   4378 C  CA  . LEU A 1 590 ? -5.972  -69.952 -11.448 1.00 28.43  ? 853  LEU A CA  1 
ATOM   4379 C  C   . LEU A 1 590 ? -7.012  -70.971 -10.965 1.00 34.26  ? 853  LEU A C   1 
ATOM   4380 O  O   . LEU A 1 590 ? -8.158  -71.065 -11.485 1.00 29.67  ? 853  LEU A O   1 
ATOM   4381 C  CB  . LEU A 1 590 ? -6.255  -68.590 -10.836 1.00 31.93  ? 853  LEU A CB  1 
ATOM   4382 C  CG  . LEU A 1 590 ? -5.244  -67.457 -11.067 1.00 38.96  ? 853  LEU A CG  1 
ATOM   4383 C  CD1 . LEU A 1 590 ? -5.602  -66.302 -10.124 1.00 41.79  ? 853  LEU A CD1 1 
ATOM   4384 C  CD2 . LEU A 1 590 ? -3.802  -67.896 -10.845 1.00 40.11  ? 853  LEU A CD2 1 
ATOM   4385 N  N   . THR A 1 591 ? -6.664  -71.665 -9.907  1.00 34.24  ? 854  THR A N   1 
ATOM   4386 C  CA  . THR A 1 591 ? -7.575  -72.574 -9.177  1.00 33.41  ? 854  THR A CA  1 
ATOM   4387 C  C   . THR A 1 591 ? -8.792  -71.819 -8.663  1.00 27.84  ? 854  THR A C   1 
ATOM   4388 O  O   . THR A 1 591 ? -9.887  -72.381 -8.716  1.00 29.37  ? 854  THR A O   1 
ATOM   4389 C  CB  . THR A 1 591 ? -6.779  -73.213 -8.021  1.00 37.54  ? 854  THR A CB  1 
ATOM   4390 O  OG1 . THR A 1 591 ? -5.702  -73.913 -8.635  1.00 45.03  ? 854  THR A OG1 1 
ATOM   4391 C  CG2 . THR A 1 591 ? -7.574  -74.184 -7.199  1.00 42.04  ? 854  THR A CG2 1 
ATOM   4392 N  N   . SER A 1 592 ? -8.644  -70.647 -8.067  1.00 26.03  ? 855  SER A N   1 
ATOM   4393 C  CA  . SER A 1 592 ? -9.824  -69.836 -7.638  1.00 27.91  ? 855  SER A CA  1 
ATOM   4394 C  C   . SER A 1 592 ? -10.825 -69.661 -8.826  1.00 29.52  ? 855  SER A C   1 
ATOM   4395 O  O   . SER A 1 592 ? -12.077 -69.796 -8.622  1.00 29.50  ? 855  SER A O   1 
ATOM   4396 C  CB  . SER A 1 592 ? -9.396  -68.534 -7.002  1.00 29.69  ? 855  SER A CB  1 
ATOM   4397 O  OG  . SER A 1 592 ? -8.649  -67.688 -7.874  1.00 33.20  ? 855  SER A OG  1 
ATOM   4398 N  N   . ARG A 1 593 ? -10.332 -69.398 -10.029 1.00 28.10  ? 856  ARG A N   1 
ATOM   4399 C  CA  . ARG A 1 593 ? -11.203 -69.033 -11.176 1.00 28.77  ? 856  ARG A CA  1 
ATOM   4400 C  C   . ARG A 1 593 ? -11.875 -70.327 -11.630 1.00 27.26  ? 856  ARG A C   1 
ATOM   4401 O  O   . ARG A 1 593 ? -13.034 -70.293 -11.949 1.00 25.49  ? 856  ARG A O   1 
ATOM   4402 C  CB  . ARG A 1 593 ? -10.373 -68.320 -12.236 1.00 27.83  ? 856  ARG A CB  1 
ATOM   4403 C  CG  . ARG A 1 593 ? -11.142 -67.725 -13.411 1.00 26.05  ? 856  ARG A CG  1 
ATOM   4404 C  CD  . ARG A 1 593 ? -11.587 -68.776 -14.417 1.00 25.05  ? 856  ARG A CD  1 
ATOM   4405 N  NE  . ARG A 1 593 ? -12.059 -68.035 -15.556 1.00 27.51  ? 856  ARG A NE  1 
ATOM   4406 C  CZ  . ARG A 1 593 ? -12.854 -68.531 -16.506 1.00 30.82  ? 856  ARG A CZ  1 
ATOM   4407 N  NH1 . ARG A 1 593 ? -13.173 -69.815 -16.490 1.00 26.45  ? 856  ARG A NH1 1 
ATOM   4408 N  NH2 . ARG A 1 593 ? -13.317 -67.735 -17.471 1.00 28.39  ? 856  ARG A NH2 1 
ATOM   4409 N  N   . ALA A 1 594 ? -11.146 -71.421 -11.689 1.00 25.99  ? 857  ALA A N   1 
ATOM   4410 C  CA  . ALA A 1 594 ? -11.691 -72.737 -12.118 1.00 30.92  ? 857  ALA A CA  1 
ATOM   4411 C  C   . ALA A 1 594 ? -12.820 -73.169 -11.172 1.00 28.67  ? 857  ALA A C   1 
ATOM   4412 O  O   . ALA A 1 594 ? -13.855 -73.658 -11.668 1.00 27.80  ? 857  ALA A O   1 
ATOM   4413 C  CB  . ALA A 1 594 ? -10.588 -73.779 -12.197 1.00 35.23  ? 857  ALA A CB  1 
ATOM   4414 N  N   . THR A 1 595 ? -12.672 -72.981 -9.878  1.00 26.35  ? 858  THR A N   1 
ATOM   4415 C  CA  . THR A 1 595 ? -13.716 -73.398 -8.927  1.00 32.66  ? 858  THR A CA  1 
ATOM   4416 C  C   . THR A 1 595 ? -14.953 -72.494 -9.094  1.00 32.52  ? 858  THR A C   1 
ATOM   4417 O  O   . THR A 1 595 ? -16.102 -72.945 -8.981  1.00 28.84  ? 858  THR A O   1 
ATOM   4418 C  CB  . THR A 1 595 ? -13.202 -73.247 -7.500  1.00 35.12  ? 858  THR A CB  1 
ATOM   4419 O  OG1 . THR A 1 595 ? -12.029 -74.052 -7.374  1.00 44.33  ? 858  THR A OG1 1 
ATOM   4420 C  CG2 . THR A 1 595 ? -14.257 -73.652 -6.501  1.00 37.60  ? 858  THR A CG2 1 
ATOM   4421 N  N   . TRP A 1 596 ? -14.716 -71.206 -9.278  1.00 28.60  ? 859  TRP A N   1 
ATOM   4422 C  CA  . TRP A 1 596 ? -15.804 -70.228 -9.526  1.00 24.58  ? 859  TRP A CA  1 
ATOM   4423 C  C   . TRP A 1 596 ? -16.578 -70.647 -10.772 1.00 22.40  ? 859  TRP A C   1 
ATOM   4424 O  O   . TRP A 1 596 ? -17.825 -70.740 -10.701 1.00 26.68  ? 859  TRP A O   1 
ATOM   4425 C  CB  . TRP A 1 596 ? -15.178 -68.835 -9.648  1.00 27.19  ? 859  TRP A CB  1 
ATOM   4426 C  CG  . TRP A 1 596 ? -16.071 -67.754 -10.161 1.00 23.01  ? 859  TRP A CG  1 
ATOM   4427 C  CD1 . TRP A 1 596 ? -17.091 -67.160 -9.482  1.00 23.68  ? 859  TRP A CD1 1 
ATOM   4428 C  CD2 . TRP A 1 596 ? -15.937 -67.072 -11.407 1.00 24.71  ? 859  TRP A CD2 1 
ATOM   4429 N  NE1 . TRP A 1 596 ? -17.613 -66.142 -10.233 1.00 23.25  ? 859  TRP A NE1 1 
ATOM   4430 C  CE2 . TRP A 1 596 ? -16.931 -66.070 -11.418 1.00 23.34  ? 859  TRP A CE2 1 
ATOM   4431 C  CE3 . TRP A 1 596 ? -15.069 -67.191 -12.499 1.00 24.81  ? 859  TRP A CE3 1 
ATOM   4432 C  CZ2 . TRP A 1 596 ? -17.058 -65.170 -12.470 1.00 23.80  ? 859  TRP A CZ2 1 
ATOM   4433 C  CZ3 . TRP A 1 596 ? -15.173 -66.282 -13.535 1.00 25.88  ? 859  TRP A CZ3 1 
ATOM   4434 C  CH2 . TRP A 1 596 ? -16.178 -65.289 -13.511 1.00 25.34  ? 859  TRP A CH2 1 
ATOM   4435 N  N   . ALA A 1 597 ? -15.897 -70.890 -11.886 1.00 23.39  ? 860  ALA A N   1 
ATOM   4436 C  CA  . ALA A 1 597 ? -16.582 -71.264 -13.156 1.00 28.03  ? 860  ALA A CA  1 
ATOM   4437 C  C   . ALA A 1 597 ? -17.384 -72.562 -12.979 1.00 31.78  ? 860  ALA A C   1 
ATOM   4438 O  O   . ALA A 1 597 ? -18.539 -72.621 -13.364 1.00 32.31  ? 860  ALA A O   1 
ATOM   4439 C  CB  . ALA A 1 597 ? -15.603 -71.386 -14.315 1.00 23.34  ? 860  ALA A CB  1 
ATOM   4440 N  N   . LYS A 1 598 ? -16.736 -73.591 -12.418 0.41 32.25  ? 861  LYS A N   1 
ATOM   4441 C  CA  . LYS A 1 598 ? -17.330 -74.935 -12.155 0.41 33.63  ? 861  LYS A CA  1 
ATOM   4442 C  C   . LYS A 1 598 ? -18.647 -74.783 -11.394 0.41 29.95  ? 861  LYS A C   1 
ATOM   4443 O  O   . LYS A 1 598 ? -19.660 -75.351 -11.833 0.41 33.13  ? 861  LYS A O   1 
ATOM   4444 C  CB  . LYS A 1 598 ? -16.362 -75.797 -11.332 0.41 35.55  ? 861  LYS A CB  1 
ATOM   4445 C  CG  . LYS A 1 598 ? -16.889 -77.153 -10.859 0.41 38.17  ? 861  LYS A CG  1 
ATOM   4446 C  CD  . LYS A 1 598 ? -15.927 -77.924 -9.954  0.41 40.77  ? 861  LYS A CD  1 
ATOM   4447 C  CE  . LYS A 1 598 ? -14.567 -78.152 -10.583 0.41 44.93  ? 861  LYS A CE  1 
ATOM   4448 N  NZ  . LYS A 1 598 ? -13.851 -79.304 -9.977  0.41 48.47  ? 861  LYS A NZ  1 
ATOM   4449 N  N   . ASN A 1 599 ? -18.614 -74.026 -10.298 0.41 29.49  ? 862  ASN A N   1 
ATOM   4450 C  CA  . ASN A 1 599 ? -19.669 -73.956 -9.254  0.41 28.24  ? 862  ASN A CA  1 
ATOM   4451 C  C   . ASN A 1 599 ? -20.547 -72.710 -9.446  0.41 26.64  ? 862  ASN A C   1 
ATOM   4452 O  O   . ASN A 1 599 ? -21.207 -72.303 -8.479  0.41 27.72  ? 862  ASN A O   1 
ATOM   4453 C  CB  . ASN A 1 599 ? -19.009 -73.999 -7.870  0.41 27.88  ? 862  ASN A CB  1 
ATOM   4454 C  CG  . ASN A 1 599 ? -18.382 -75.349 -7.598  0.41 27.06  ? 862  ASN A CG  1 
ATOM   4455 O  OD1 . ASN A 1 599 ? -19.100 -76.329 -7.462  0.41 27.14  ? 862  ASN A OD1 1 
ATOM   4456 N  ND2 . ASN A 1 599 ? -17.061 -75.428 -7.587  0.41 25.58  ? 862  ASN A ND2 1 
ATOM   4457 N  N   . ILE A 1 600 ? -20.572 -72.124 -10.643 1.00 26.83  ? 863  ILE A N   1 
ATOM   4458 C  CA  . ILE A 1 600 ? -21.271 -70.812 -10.859 1.00 24.52  ? 863  ILE A CA  1 
ATOM   4459 C  C   . ILE A 1 600 ? -22.787 -70.883 -10.528 1.00 26.70  ? 863  ILE A C   1 
ATOM   4460 O  O   . ILE A 1 600 ? -23.333 -69.916 -10.014 1.00 24.65  ? 863  ILE A O   1 
ATOM   4461 C  CB  . ILE A 1 600 ? -20.961 -70.246 -12.256 1.00 23.66  ? 863  ILE A CB  1 
ATOM   4462 C  CG1 . ILE A 1 600 ? -21.299 -68.763 -12.323 1.00 26.99  ? 863  ILE A CG1 1 
ATOM   4463 C  CG2 . ILE A 1 600 ? -21.656 -71.003 -13.396 1.00 26.04  ? 863  ILE A CG2 1 
ATOM   4464 C  CD1 . ILE A 1 600 ? -20.414 -67.913 -11.546 1.00 25.36  ? 863  ILE A CD1 1 
ATOM   4465 N  N   A GLN A 1 601 ? -23.440 -72.023 -10.776 0.20 27.57  ? 864  GLN A N   1 
ATOM   4466 N  N   B GLN A 1 601 ? -23.433 -72.029 -10.770 0.21 27.81  ? 864  GLN A N   1 
ATOM   4467 C  CA  A GLN A 1 601 ? -24.899 -72.184 -10.514 0.20 28.26  ? 864  GLN A CA  1 
ATOM   4468 C  CA  B GLN A 1 601 ? -24.890 -72.196 -10.505 0.21 28.65  ? 864  GLN A CA  1 
ATOM   4469 C  C   A GLN A 1 601 ? -25.200 -72.033 -9.013  0.20 27.85  ? 864  GLN A C   1 
ATOM   4470 C  C   B GLN A 1 601 ? -25.189 -72.012 -9.010  0.21 28.07  ? 864  GLN A C   1 
ATOM   4471 O  O   A GLN A 1 601 ? -26.283 -71.508 -8.685  0.20 28.74  ? 864  GLN A O   1 
ATOM   4472 O  O   B GLN A 1 601 ? -26.261 -71.459 -8.688  0.21 28.86  ? 864  GLN A O   1 
ATOM   4473 C  CB  A GLN A 1 601 ? -25.421 -73.500 -11.093 0.20 29.23  ? 864  GLN A CB  1 
ATOM   4474 C  CB  B GLN A 1 601 ? -25.406 -73.545 -11.004 0.21 30.03  ? 864  GLN A CB  1 
ATOM   4475 C  CG  A GLN A 1 601 ? -25.549 -73.481 -12.615 0.20 28.74  ? 864  GLN A CG  1 
ATOM   4476 C  CG  B GLN A 1 601 ? -26.923 -73.602 -11.121 0.21 29.71  ? 864  GLN A CG  1 
ATOM   4477 C  CD  A GLN A 1 601 ? -26.698 -72.644 -13.124 0.20 28.58  ? 864  GLN A CD  1 
ATOM   4478 C  CD  B GLN A 1 601 ? -27.504 -72.434 -11.879 0.21 30.72  ? 864  GLN A CD  1 
ATOM   4479 O  OE1 A GLN A 1 601 ? -27.672 -72.400 -12.419 0.20 29.16  ? 864  GLN A OE1 1 
ATOM   4480 O  OE1 B GLN A 1 601 ? -27.079 -72.112 -12.986 0.21 30.87  ? 864  GLN A OE1 1 
ATOM   4481 N  NE2 A GLN A 1 601 ? -26.606 -72.215 -14.377 0.20 27.71  ? 864  GLN A NE2 1 
ATOM   4482 N  NE2 B GLN A 1 601 ? -28.483 -71.774 -11.277 0.21 31.58  ? 864  GLN A NE2 1 
ATOM   4483 N  N   . THR A 1 602 ? -24.278 -72.437 -8.140  1.00 27.37  ? 865  THR A N   1 
ATOM   4484 C  CA  . THR A 1 602 ? -24.404 -72.249 -6.667  1.00 28.89  ? 865  THR A CA  1 
ATOM   4485 C  C   . THR A 1 602 ? -24.368 -70.757 -6.318  1.00 27.66  ? 865  THR A C   1 
ATOM   4486 O  O   . THR A 1 602 ? -25.098 -70.321 -5.413  1.00 28.47  ? 865  THR A O   1 
ATOM   4487 C  CB  . THR A 1 602 ? -23.284 -73.019 -5.960  1.00 31.08  ? 865  THR A CB  1 
ATOM   4488 O  OG1 . THR A 1 602 ? -23.439 -74.369 -6.409  1.00 37.04  ? 865  THR A OG1 1 
ATOM   4489 C  CG2 . THR A 1 602 ? -23.379 -72.950 -4.466  1.00 36.56  ? 865  THR A CG2 1 
ATOM   4490 N  N   . ALA A 1 603 ? -23.533 -69.975 -7.000  1.00 26.73  ? 866  ALA A N   1 
ATOM   4491 C  CA  . ALA A 1 603 ? -23.414 -68.538 -6.723  1.00 25.69  ? 866  ALA A CA  1 
ATOM   4492 C  C   . ALA A 1 603 ? -24.668 -67.862 -7.220  1.00 23.70  ? 866  ALA A C   1 
ATOM   4493 O  O   . ALA A 1 603 ? -25.223 -67.002 -6.531  1.00 24.85  ? 866  ALA A O   1 
ATOM   4494 C  CB  . ALA A 1 603 ? -22.230 -67.957 -7.403  1.00 27.68  ? 866  ALA A CB  1 
ATOM   4495 N  N   . ILE A 1 604 ? -25.088 -68.261 -8.415  1.00 25.99  ? 867  ILE A N   1 
ATOM   4496 C  CA  . ILE A 1 604 ? -26.326 -67.706 -9.024  1.00 26.64  ? 867  ILE A CA  1 
ATOM   4497 C  C   . ILE A 1 604 ? -27.487 -67.956 -8.043  1.00 25.74  ? 867  ILE A C   1 
ATOM   4498 O  O   . ILE A 1 604 ? -28.233 -67.038 -7.762  1.00 25.06  ? 867  ILE A O   1 
ATOM   4499 C  CB  . ILE A 1 604 ? -26.541 -68.318 -10.409 1.00 28.70  ? 867  ILE A CB  1 
ATOM   4500 C  CG1 . ILE A 1 604 ? -25.550 -67.732 -11.409 1.00 25.81  ? 867  ILE A CG1 1 
ATOM   4501 C  CG2 . ILE A 1 604 ? -27.966 -68.117 -10.872 1.00 27.59  ? 867  ILE A CG2 1 
ATOM   4502 C  CD1 . ILE A 1 604 ? -25.492 -68.495 -12.730 1.00 30.39  ? 867  ILE A CD1 1 
ATOM   4503 N  N   . ASN A 1 605 ? -27.576 -69.178 -7.513  0.41 27.39  ? 868  ASN A N   1 
ATOM   4504 C  CA  . ASN A 1 605 ? -28.689 -69.623 -6.630  0.41 28.95  ? 868  ASN A CA  1 
ATOM   4505 C  C   . ASN A 1 605 ? -28.605 -68.882 -5.284  0.41 27.83  ? 868  ASN A C   1 
ATOM   4506 O  O   . ASN A 1 605 ? -29.668 -68.617 -4.701  0.41 27.37  ? 868  ASN A O   1 
ATOM   4507 C  CB  . ASN A 1 605 ? -28.717 -71.153 -6.513  0.41 30.66  ? 868  ASN A CB  1 
ATOM   4508 C  CG  . ASN A 1 605 ? -29.270 -71.840 -7.751  0.41 32.86  ? 868  ASN A CG  1 
ATOM   4509 O  OD1 . ASN A 1 605 ? -29.285 -71.286 -8.854  0.41 36.75  ? 868  ASN A OD1 1 
ATOM   4510 N  ND2 . ASN A 1 605 ? -29.749 -73.058 -7.584  0.41 33.63  ? 868  ASN A ND2 1 
ATOM   4511 N  N   . GLN A 1 606 ? -27.402 -68.524 -4.819  1.00 28.57  ? 869  GLN A N   1 
ATOM   4512 C  CA  . GLN A 1 606 ? -27.264 -67.744 -3.575  1.00 26.10  ? 869  GLN A CA  1 
ATOM   4513 C  C   . GLN A 1 606 ? -27.957 -66.394 -3.764  1.00 25.02  ? 869  GLN A C   1 
ATOM   4514 O  O   . GLN A 1 606 ? -28.655 -65.940 -2.837  1.00 29.10  ? 869  GLN A O   1 
ATOM   4515 C  CB  . GLN A 1 606 ? -25.832 -67.523 -3.114  1.00 28.59  ? 869  GLN A CB  1 
ATOM   4516 C  CG  . GLN A 1 606 ? -25.729 -66.756 -1.790  1.00 32.51  ? 869  GLN A CG  1 
ATOM   4517 C  CD  . GLN A 1 606 ? -24.301 -66.426 -1.377  1.00 39.15  ? 869  GLN A CD  1 
ATOM   4518 O  OE1 . GLN A 1 606 ? -23.410 -66.315 -2.223  1.00 36.93  ? 869  GLN A OE1 1 
ATOM   4519 N  NE2 . GLN A 1 606 ? -24.071 -66.279 -0.073  1.00 35.27  ? 869  GLN A NE2 1 
ATOM   4520 N  N   . VAL A 1 607 ? -27.713 -65.733 -4.889  1.00 24.39  ? 870  VAL A N   1 
ATOM   4521 C  CA  . VAL A 1 607 ? -28.261 -64.388 -5.165  1.00 22.68  ? 870  VAL A CA  1 
ATOM   4522 C  C   . VAL A 1 607 ? -29.766 -64.524 -5.440  1.00 22.48  ? 870  VAL A C   1 
ATOM   4523 O  O   . VAL A 1 607 ? -30.530 -63.739 -4.864  1.00 24.05  ? 870  VAL A O   1 
ATOM   4524 C  CB  . VAL A 1 607 ? -27.514 -63.718 -6.328  1.00 24.33  ? 870  VAL A CB  1 
ATOM   4525 C  CG1 . VAL A 1 607 ? -28.236 -62.466 -6.780  1.00 23.86  ? 870  VAL A CG1 1 
ATOM   4526 C  CG2 . VAL A 1 607 ? -26.102 -63.428 -5.915  1.00 21.35  ? 870  VAL A CG2 1 
ATOM   4527 N  N   . ARG A 1 608 ? -30.180 -65.537 -6.210  1.00 23.33  ? 871  ARG A N   1 
ATOM   4528 C  CA  . ARG A 1 608 ? -31.636 -65.770 -6.412  1.00 27.66  ? 871  ARG A CA  1 
ATOM   4529 C  C   . ARG A 1 608 ? -32.345 -65.930 -5.074  1.00 26.15  ? 871  ARG A C   1 
ATOM   4530 O  O   . ARG A 1 608 ? -33.473 -65.365 -4.897  1.00 28.95  ? 871  ARG A O   1 
ATOM   4531 C  CB  . ARG A 1 608 ? -31.852 -66.968 -7.325  1.00 25.21  ? 871  ARG A CB  1 
ATOM   4532 C  CG  . ARG A 1 608 ? -31.497 -66.705 -8.786  1.00 25.27  ? 871  ARG A CG  1 
ATOM   4533 C  CD  . ARG A 1 608 ? -31.721 -68.010 -9.516  1.00 24.35  ? 871  ARG A CD  1 
ATOM   4534 N  NE  . ARG A 1 608 ? -31.642 -67.792 -10.925 1.00 28.32  ? 871  ARG A NE  1 
ATOM   4535 C  CZ  . ARG A 1 608 ? -31.565 -68.752 -11.824 1.00 33.14  ? 871  ARG A CZ  1 
ATOM   4536 N  NH1 . ARG A 1 608 ? -31.623 -70.024 -11.454 1.00 39.60  ? 871  ARG A NH1 1 
ATOM   4537 N  NH2 . ARG A 1 608 ? -31.465 -68.443 -13.105 1.00 30.80  ? 871  ARG A NH2 1 
ATOM   4538 N  N   . SER A 1 609 ? -31.812 -66.721 -4.172  1.00 25.34  ? 872  SER A N   1 
ATOM   4539 C  CA  . SER A 1 609 ? -32.448 -66.910 -2.833  1.00 28.33  ? 872  SER A CA  1 
ATOM   4540 C  C   . SER A 1 609 ? -32.566 -65.578 -2.092  1.00 28.77  ? 872  SER A C   1 
ATOM   4541 O  O   . SER A 1 609 ? -33.453 -65.462 -1.273  1.00 27.52  ? 872  SER A O   1 
ATOM   4542 C  CB  . SER A 1 609 ? -31.701 -67.921 -1.994  1.00 27.18  ? 872  SER A CB  1 
ATOM   4543 O  OG  . SER A 1 609 ? -31.627 -69.150 -2.722  1.00 29.88  ? 872  SER A OG  1 
ATOM   4544 N  N   . LEU A 1 610 ? -31.598 -64.659 -2.208  1.00 26.30  ? 873  LEU A N   1 
ATOM   4545 C  CA  . LEU A 1 610 ? -31.669 -63.378 -1.460  1.00 25.96  ? 873  LEU A CA  1 
ATOM   4546 C  C   . LEU A 1 610 ? -32.785 -62.523 -2.086  1.00 26.57  ? 873  LEU A C   1 
ATOM   4547 O  O   . LEU A 1 610 ? -33.469 -61.777 -1.372  1.00 25.51  ? 873  LEU A O   1 
ATOM   4548 C  CB  . LEU A 1 610 ? -30.284 -62.712 -1.524  1.00 27.74  ? 873  LEU A CB  1 
ATOM   4549 C  CG  . LEU A 1 610 ? -29.210 -63.430 -0.730  1.00 25.52  ? 873  LEU A CG  1 
ATOM   4550 C  CD1 . LEU A 1 610 ? -27.816 -62.895 -1.040  1.00 30.42  ? 873  LEU A CD1 1 
ATOM   4551 C  CD2 . LEU A 1 610 ? -29.484 -63.340 0.780   1.00 26.86  ? 873  LEU A CD2 1 
ATOM   4552 N  N   . ILE A 1 611 ? -32.867 -62.485 -3.406  1.00 28.95  ? 874  ILE A N   1 
ATOM   4553 C  CA  . ILE A 1 611 ? -33.854 -61.612 -4.108  1.00 26.88  ? 874  ILE A CA  1 
ATOM   4554 C  C   . ILE A 1 611 ? -35.277 -62.174 -3.897  1.00 30.24  ? 874  ILE A C   1 
ATOM   4555 O  O   . ILE A 1 611 ? -36.224 -61.364 -3.679  1.00 30.45  ? 874  ILE A O   1 
ATOM   4556 C  CB  . ILE A 1 611 ? -33.449 -61.440 -5.591  1.00 28.31  ? 874  ILE A CB  1 
ATOM   4557 C  CG1 . ILE A 1 611 ? -32.110 -60.704 -5.691  1.00 27.07  ? 874  ILE A CG1 1 
ATOM   4558 C  CG2 . ILE A 1 611 ? -34.529 -60.704 -6.363  1.00 27.76  ? 874  ILE A CG2 1 
ATOM   4559 C  CD1 . ILE A 1 611 ? -31.662 -60.411 -7.072  1.00 28.65  ? 874  ILE A CD1 1 
ATOM   4560 N  N   . GLY A 1 612 ? -35.394 -63.503 -3.918  0.41 29.41  ? 875  GLY A N   1 
ATOM   4561 C  CA  . GLY A 1 612 ? -36.628 -64.258 -3.616  0.41 31.89  ? 875  GLY A CA  1 
ATOM   4562 C  C   . GLY A 1 612 ? -37.284 -64.817 -4.870  0.41 31.85  ? 875  GLY A C   1 
ATOM   4563 O  O   . GLY A 1 612 ? -36.721 -64.671 -5.984  0.41 26.48  ? 875  GLY A O   1 
ATOM   4564 N  N   . ASN A 1 613 ? -38.477 -65.388 -4.693  0.41 35.71  ? 876  ASN A N   1 
ATOM   4565 C  CA  . ASN A 1 613 ? -39.259 -66.081 -5.750  0.41 36.32  ? 876  ASN A CA  1 
ATOM   4566 C  C   . ASN A 1 613 ? -39.648 -65.074 -6.843  0.41 34.91  ? 876  ASN A C   1 
ATOM   4567 O  O   . ASN A 1 613 ? -40.560 -64.232 -6.609  0.41 34.27  ? 876  ASN A O   1 
ATOM   4568 C  CB  . ASN A 1 613 ? -40.492 -66.764 -5.153  0.41 39.54  ? 876  ASN A CB  1 
ATOM   4569 C  CG  . ASN A 1 613 ? -41.200 -67.656 -6.148  0.41 41.22  ? 876  ASN A CG  1 
ATOM   4570 O  OD1 . ASN A 1 613 ? -40.968 -67.547 -7.350  0.41 38.84  ? 876  ASN A OD1 1 
ATOM   4571 N  ND2 . ASN A 1 613 ? -42.047 -68.551 -5.653  0.41 44.20  ? 876  ASN A ND2 1 
ATOM   4572 N  N   . GLU A 1 614 ? -39.015 -65.200 -8.008  0.41 28.42  ? 877  GLU A N   1 
ATOM   4573 C  CA  . GLU A 1 614 ? -39.104 -64.249 -9.141  0.41 28.53  ? 877  GLU A CA  1 
ATOM   4574 C  C   . GLU A 1 614 ? -38.951 -65.067 -10.430 0.41 28.84  ? 877  GLU A C   1 
ATOM   4575 O  O   . GLU A 1 614 ? -38.674 -66.297 -10.324 0.41 30.70  ? 877  GLU A O   1 
ATOM   4576 C  CB  . GLU A 1 614 ? -38.032 -63.159 -9.007  0.41 27.87  ? 877  GLU A CB  1 
ATOM   4577 C  CG  . GLU A 1 614 ? -38.186 -62.263 -7.788  0.41 27.39  ? 877  GLU A CG  1 
ATOM   4578 C  CD  . GLU A 1 614 ? -39.459 -61.432 -7.758  0.41 27.43  ? 877  GLU A CD  1 
ATOM   4579 O  OE1 . GLU A 1 614 ? -40.057 -61.228 -8.830  0.41 27.23  ? 877  GLU A OE1 1 
ATOM   4580 O  OE2 . GLU A 1 614 ? -39.834 -60.982 -6.665  0.41 28.65  ? 877  GLU A OE2 1 
ATOM   4581 N  N   . GLU A 1 615 ? -39.173 -64.446 -11.597 0.41 31.67  ? 878  GLU A N   1 
ATOM   4582 C  CA  . GLU A 1 615 ? -38.970 -65.124 -12.909 0.41 36.07  ? 878  GLU A CA  1 
ATOM   4583 C  C   . GLU A 1 615 ? -37.495 -64.973 -13.296 0.41 37.14  ? 878  GLU A C   1 
ATOM   4584 O  O   . GLU A 1 615 ? -37.082 -63.841 -13.595 0.41 35.70  ? 878  GLU A O   1 
ATOM   4585 C  CB  . GLU A 1 615 ? -39.879 -64.565 -14.011 0.41 36.61  ? 878  GLU A CB  1 
ATOM   4586 C  CG  . GLU A 1 615 ? -39.466 -65.012 -15.412 0.41 38.90  ? 878  GLU A CG  1 
ATOM   4587 C  CD  . GLU A 1 615 ? -40.414 -64.643 -16.549 0.41 43.09  ? 878  GLU A CD  1 
ATOM   4588 O  OE1 . GLU A 1 615 ? -41.422 -63.944 -16.287 0.41 41.11  ? 878  GLU A OE1 1 
ATOM   4589 O  OE2 . GLU A 1 615 ? -40.145 -65.059 -17.708 0.41 45.46  ? 878  GLU A OE2 1 
ATOM   4590 N  N   . TYR A 1 616 ? -36.756 -66.083 -13.313 0.41 39.20  ? 879  TYR A N   1 
ATOM   4591 C  CA  . TYR A 1 616 ? -35.311 -66.151 -13.644 0.41 40.18  ? 879  TYR A CA  1 
ATOM   4592 C  C   . TYR A 1 616 ? -35.100 -66.989 -14.908 0.41 43.39  ? 879  TYR A C   1 
ATOM   4593 O  O   . TYR A 1 616 ? -35.800 -68.007 -15.086 0.41 39.98  ? 879  TYR A O   1 
ATOM   4594 C  CB  . TYR A 1 616 ? -34.537 -66.759 -12.476 0.41 39.15  ? 879  TYR A CB  1 
ATOM   4595 C  CG  . TYR A 1 616 ? -34.551 -65.934 -11.215 0.41 36.36  ? 879  TYR A CG  1 
ATOM   4596 C  CD1 . TYR A 1 616 ? -33.802 -64.775 -11.115 0.41 34.07  ? 879  TYR A CD1 1 
ATOM   4597 C  CD2 . TYR A 1 616 ? -35.278 -66.339 -10.106 0.41 34.86  ? 879  TYR A CD2 1 
ATOM   4598 C  CE1 . TYR A 1 616 ? -33.793 -64.021 -9.953  0.41 34.90  ? 879  TYR A CE1 1 
ATOM   4599 C  CE2 . TYR A 1 616 ? -35.274 -65.602 -8.934  0.41 33.89  ? 879  TYR A CE2 1 
ATOM   4600 C  CZ  . TYR A 1 616 ? -34.522 -64.440 -8.855  0.41 33.67  ? 879  TYR A CZ  1 
ATOM   4601 O  OH  . TYR A 1 616 ? -34.500 -63.689 -7.715  0.41 34.17  ? 879  TYR A OH  1 
ATOM   4602 N  N   . THR A 1 617 ? -34.147 -66.561 -15.743 0.41 46.11  ? 880  THR A N   1 
ATOM   4603 C  CA  . THR A 1 617 ? -33.715 -67.230 -16.999 0.41 47.26  ? 880  THR A CA  1 
ATOM   4604 C  C   . THR A 1 617 ? -32.217 -67.544 -16.892 0.41 46.84  ? 880  THR A C   1 
ATOM   4605 O  O   . THR A 1 617 ? -31.436 -66.594 -16.678 0.41 44.32  ? 880  THR A O   1 
ATOM   4606 C  CB  . THR A 1 617 ? -34.033 -66.343 -18.209 0.41 50.22  ? 880  THR A CB  1 
ATOM   4607 O  OG1 . THR A 1 617 ? -35.443 -66.117 -18.195 0.41 47.79  ? 880  THR A OG1 1 
ATOM   4608 C  CG2 . THR A 1 617 ? -33.605 -66.949 -19.530 0.41 52.13  ? 880  THR A CG2 1 
ATOM   4609 N  N   . ASP A 1 618 ? -31.842 -68.822 -17.018 0.41 47.25  ? 881  ASP A N   1 
ATOM   4610 C  CA  . ASP A 1 618 ? -30.426 -69.275 -17.080 0.41 48.49  ? 881  ASP A CA  1 
ATOM   4611 C  C   . ASP A 1 618 ? -29.829 -68.791 -18.410 0.41 48.10  ? 881  ASP A C   1 
ATOM   4612 O  O   . ASP A 1 618 ? -30.431 -69.081 -19.468 0.41 45.58  ? 881  ASP A O   1 
ATOM   4613 C  CB  . ASP A 1 618 ? -30.320 -70.798 -16.921 0.41 49.72  ? 881  ASP A CB  1 
ATOM   4614 C  CG  . ASP A 1 618 ? -28.952 -71.301 -16.470 0.41 53.15  ? 881  ASP A CG  1 
ATOM   4615 O  OD1 . ASP A 1 618 ? -28.044 -70.462 -16.285 0.41 46.79  ? 881  ASP A OD1 1 
ATOM   4616 O  OD2 . ASP A 1 618 ? -28.804 -72.534 -16.290 0.41 54.15  ? 881  ASP A OD2 1 
ATOM   4617 N  N   . TYR A 1 619 ? -28.701 -68.070 -18.358 0.41 48.05  ? 882  TYR A N   1 
ATOM   4618 C  CA  . TYR A 1 619 ? -27.936 -67.605 -19.547 0.41 48.20  ? 882  TYR A CA  1 
ATOM   4619 C  C   . TYR A 1 619 ? -26.552 -68.269 -19.595 0.41 49.47  ? 882  TYR A C   1 
ATOM   4620 O  O   . TYR A 1 619 ? -25.700 -67.816 -20.388 0.41 48.92  ? 882  TYR A O   1 
ATOM   4621 C  CB  . TYR A 1 619 ? -27.813 -66.079 -19.535 0.41 48.58  ? 882  TYR A CB  1 
ATOM   4622 C  CG  . TYR A 1 619 ? -29.125 -65.346 -19.626 0.41 49.97  ? 882  TYR A CG  1 
ATOM   4623 C  CD1 . TYR A 1 619 ? -29.834 -65.292 -20.817 0.41 50.50  ? 882  TYR A CD1 1 
ATOM   4624 C  CD2 . TYR A 1 619 ? -29.660 -64.701 -18.523 0.41 48.06  ? 882  TYR A CD2 1 
ATOM   4625 C  CE1 . TYR A 1 619 ? -31.042 -64.617 -20.910 0.41 50.16  ? 882  TYR A CE1 1 
ATOM   4626 C  CE2 . TYR A 1 619 ? -30.864 -64.019 -18.600 0.41 50.77  ? 882  TYR A CE2 1 
ATOM   4627 C  CZ  . TYR A 1 619 ? -31.559 -63.975 -19.796 0.41 51.56  ? 882  TYR A CZ  1 
ATOM   4628 O  OH  . TYR A 1 619 ? -32.744 -63.298 -19.860 0.41 52.25  ? 882  TYR A OH  1 
ATOM   4629 N  N   . MET A 1 620 ? -26.316 -69.300 -18.777 0.41 52.84  ? 883  MET A N   1 
ATOM   4630 C  CA  . MET A 1 620 ? -25.039 -70.068 -18.775 0.41 57.31  ? 883  MET A CA  1 
ATOM   4631 C  C   . MET A 1 620 ? -25.008 -71.059 -19.945 0.41 62.15  ? 883  MET A C   1 
ATOM   4632 O  O   . MET A 1 620 ? -23.964 -71.201 -20.579 0.41 66.99  ? 883  MET A O   1 
ATOM   4633 C  CB  . MET A 1 620 ? -24.804 -70.796 -17.445 0.41 55.27  ? 883  MET A CB  1 
ATOM   4634 C  CG  . MET A 1 620 ? -24.889 -69.898 -16.205 0.41 54.25  ? 883  MET A CG  1 
ATOM   4635 S  SD  . MET A 1 620 ? -23.978 -68.324 -16.315 0.41 53.71  ? 883  MET A SD  1 
ATOM   4636 C  CE  . MET A 1 620 ? -22.328 -68.902 -16.708 0.41 52.65  ? 883  MET A CE  1 
ATOM   4637 N  N   . PRO A 1 621 ? -26.114 -71.765 -20.299 0.41 67.87  ? 884  PRO A N   1 
ATOM   4638 C  CA  . PRO A 1 621 ? -26.117 -72.669 -21.457 0.41 70.87  ? 884  PRO A CA  1 
ATOM   4639 C  C   . PRO A 1 621 ? -25.663 -72.062 -22.797 0.41 70.53  ? 884  PRO A C   1 
ATOM   4640 O  O   . PRO A 1 621 ? -25.230 -72.826 -23.650 0.41 71.81  ? 884  PRO A O   1 
ATOM   4641 C  CB  . PRO A 1 621 ? -27.592 -73.098 -21.570 0.41 71.34  ? 884  PRO A CB  1 
ATOM   4642 C  CG  . PRO A 1 621 ? -28.106 -73.011 -20.152 0.41 69.92  ? 884  PRO A CG  1 
ATOM   4643 C  CD  . PRO A 1 621 ? -27.399 -71.799 -19.578 0.41 70.97  ? 884  PRO A CD  1 
ATOM   4644 N  N   . SER A 1 622 ? -25.781 -70.735 -22.961 0.41 69.95  ? 885  SER A N   1 
ATOM   4645 C  CA  . SER A 1 622 ? -25.270 -69.963 -24.129 0.41 68.95  ? 885  SER A CA  1 
ATOM   4646 C  C   . SER A 1 622 ? -23.780 -70.267 -24.348 0.41 68.59  ? 885  SER A C   1 
ATOM   4647 O  O   . SER A 1 622 ? -23.366 -70.396 -25.523 0.41 67.05  ? 885  SER A O   1 
ATOM   4648 C  CB  . SER A 1 622 ? -25.509 -68.475 -23.964 0.41 70.06  ? 885  SER A CB  1 
ATOM   4649 O  OG  . SER A 1 622 ? -24.687 -67.921 -22.946 0.41 67.75  ? 885  SER A OG  1 
ATOM   4650 N  N   . MET A 1 623 ? -23.017 -70.380 -23.254 0.41 64.72  ? 886  MET A N   1 
ATOM   4651 C  CA  . MET A 1 623 ? -21.568 -70.714 -23.263 0.41 67.67  ? 886  MET A CA  1 
ATOM   4652 C  C   . MET A 1 623 ? -21.394 -72.217 -23.519 0.41 68.24  ? 886  MET A C   1 
ATOM   4653 O  O   . MET A 1 623 ? -22.163 -73.010 -22.941 0.41 66.81  ? 886  MET A O   1 
ATOM   4654 C  CB  . MET A 1 623 ? -20.903 -70.341 -21.933 0.41 68.39  ? 886  MET A CB  1 
ATOM   4655 C  CG  . MET A 1 623 ? -20.972 -68.858 -21.608 0.41 67.71  ? 886  MET A CG  1 
ATOM   4656 S  SD  . MET A 1 623 ? -19.861 -68.372 -20.250 0.41 62.95  ? 886  MET A SD  1 
ATOM   4657 C  CE  . MET A 1 623 ? -18.342 -68.067 -21.150 0.41 63.48  ? 886  MET A CE  1 
ATOM   4658 N  N   . LYS A 1 624 ? -20.407 -72.574 -24.347 1.00 66.87  ? 887  LYS A N   1 
ATOM   4659 C  CA  . LYS A 1 624 ? -20.095 -73.985 -24.739 1.00 75.06  ? 887  LYS A CA  1 
ATOM   4660 C  C   . LYS A 1 624 ? -19.952 -74.932 -23.527 1.00 73.61  ? 887  LYS A C   1 
ATOM   4661 O  O   . LYS A 1 624 ? -20.509 -76.047 -23.586 1.00 63.54  ? 887  LYS A O   1 
ATOM   4662 C  CB  . LYS A 1 624 ? -18.809 -74.024 -25.582 1.00 81.94  ? 887  LYS A CB  1 
ATOM   4663 C  CG  . LYS A 1 624 ? -18.621 -75.305 -26.394 1.00 89.96  ? 887  LYS A CG  1 
ATOM   4664 C  CD  . LYS A 1 624 ? -17.587 -75.209 -27.512 1.00 101.60 ? 887  LYS A CD  1 
ATOM   4665 C  CE  . LYS A 1 624 ? -16.354 -76.071 -27.291 1.00 109.81 ? 887  LYS A CE  1 
ATOM   4666 N  NZ  . LYS A 1 624 ? -15.410 -75.482 -26.308 1.00 109.18 ? 887  LYS A NZ  1 
ATOM   4667 N  N   . ARG A 1 625 ? -19.219 -74.536 -22.480 1.00 73.07  ? 888  ARG A N   1 
ATOM   4668 C  CA  . ARG A 1 625 ? -18.862 -75.435 -21.339 1.00 77.07  ? 888  ARG A CA  1 
ATOM   4669 C  C   . ARG A 1 625 ? -20.084 -75.786 -20.460 1.00 71.85  ? 888  ARG A C   1 
ATOM   4670 O  O   . ARG A 1 625 ? -19.975 -76.759 -19.709 1.00 63.29  ? 888  ARG A O   1 
ATOM   4671 C  CB  . ARG A 1 625 ? -17.755 -74.815 -20.478 1.00 79.18  ? 888  ARG A CB  1 
ATOM   4672 C  CG  . ARG A 1 625 ? -18.159 -73.577 -19.685 1.00 79.72  ? 888  ARG A CG  1 
ATOM   4673 C  CD  . ARG A 1 625 ? -17.130 -73.216 -18.624 1.00 79.05  ? 888  ARG A CD  1 
ATOM   4674 N  NE  . ARG A 1 625 ? -17.038 -74.224 -17.564 1.00 79.24  ? 888  ARG A NE  1 
ATOM   4675 C  CZ  . ARG A 1 625 ? -15.974 -74.428 -16.781 1.00 69.58  ? 888  ARG A CZ  1 
ATOM   4676 N  NH1 . ARG A 1 625 ? -14.873 -73.699 -16.938 1.00 69.45  ? 888  ARG A NH1 1 
ATOM   4677 N  NH2 . ARG A 1 625 ? -16.017 -75.379 -15.857 1.00 58.99  ? 888  ARG A NH2 1 
ATOM   4678 N  N   . PHE A 1 626 ? -21.180 -75.010 -20.496 1.00 74.77  ? 889  PHE A N   1 
ATOM   4679 C  CA  . PHE A 1 626 ? -22.425 -75.251 -19.703 1.00 72.04  ? 889  PHE A CA  1 
ATOM   4680 C  C   . PHE A 1 626 ? -23.503 -75.834 -20.637 1.00 78.48  ? 889  PHE A C   1 
ATOM   4681 O  O   . PHE A 1 626 ? -24.675 -76.075 -20.217 1.00 69.47  ? 889  PHE A O   1 
ATOM   4682 C  CB  . PHE A 1 626 ? -22.859 -73.966 -18.974 1.00 65.74  ? 889  PHE A CB  1 
ATOM   4683 C  CG  . PHE A 1 626 ? -21.812 -73.360 -18.061 1.00 67.48  ? 889  PHE A CG  1 
ATOM   4684 C  CD1 . PHE A 1 626 ? -21.452 -73.979 -16.865 1.00 66.85  ? 889  PHE A CD1 1 
ATOM   4685 C  CD2 . PHE A 1 626 ? -21.167 -72.180 -18.403 1.00 58.00  ? 889  PHE A CD2 1 
ATOM   4686 C  CE1 . PHE A 1 626 ? -20.463 -73.442 -16.048 1.00 75.96  ? 889  PHE A CE1 1 
ATOM   4687 C  CE2 . PHE A 1 626 ? -20.187 -71.634 -17.579 1.00 68.53  ? 889  PHE A CE2 1 
ATOM   4688 C  CZ  . PHE A 1 626 ? -19.831 -72.262 -16.399 1.00 65.38  ? 889  PHE A CZ  1 
ATOM   4689 N  N   . ARG A 1 627 ? -23.126 -76.069 -21.895 1.00 82.08  ? 890  ARG A N   1 
ATOM   4690 C  CA  . ARG A 1 627 ? -24.024 -76.632 -22.930 1.00 112.06 ? 890  ARG A CA  1 
ATOM   4691 C  C   . ARG A 1 627 ? -23.769 -78.151 -22.998 1.00 136.59 ? 890  ARG A C   1 
ATOM   4692 O  O   . ARG A 1 627 ? -23.162 -78.599 -23.994 1.00 167.26 ? 890  ARG A O   1 
ATOM   4693 C  CB  . ARG A 1 627 ? -23.806 -75.871 -24.248 1.00 111.25 ? 890  ARG A CB  1 
ATOM   4694 C  CG  . ARG A 1 627 ? -24.975 -75.950 -25.221 1.00 110.88 ? 890  ARG A CG  1 
ATOM   4695 C  CD  . ARG A 1 627 ? -24.740 -75.172 -26.498 1.00 105.10 ? 890  ARG A CD  1 
ATOM   4696 N  NE  . ARG A 1 627 ? -23.369 -75.331 -26.960 1.00 107.54 ? 890  ARG A NE  1 
ATOM   4697 C  CZ  . ARG A 1 627 ? -22.907 -76.314 -27.737 1.00 101.92 ? 890  ARG A CZ  1 
ATOM   4698 N  NH1 . ARG A 1 627 ? -23.709 -77.271 -28.177 1.00 110.24 ? 890  ARG A NH1 1 
ATOM   4699 N  NH2 . ARG A 1 627 ? -21.632 -76.328 -28.087 1.00 90.91  ? 890  ARG A NH2 1 
ATOM   4700 N  N   . ARG A 1 628 ? -24.165 -78.898 -21.951 1.00 140.32 ? 891  ARG A N   1 
ATOM   4701 C  CA  . ARG A 1 628 ? -24.338 -80.384 -21.953 1.00 135.72 ? 891  ARG A CA  1 
ATOM   4702 C  C   . ARG A 1 628 ? -23.091 -81.113 -22.484 1.00 124.70 ? 891  ARG A C   1 
ATOM   4703 O  O   . ARG A 1 628 ? -21.932 -80.843 -22.183 1.00 101.05 ? 891  ARG A O   1 
ATOM   4704 C  CB  . ARG A 1 628 ? -25.539 -80.752 -22.832 1.00 134.20 ? 891  ARG A CB  1 
ATOM   4705 C  CG  . ARG A 1 628 ? -26.861 -80.158 -22.367 1.00 130.34 ? 891  ARG A CG  1 
ATOM   4706 C  CD  . ARG A 1 628 ? -27.148 -80.522 -20.924 1.00 133.30 ? 891  ARG A CD  1 
ATOM   4707 N  NE  . ARG A 1 628 ? -26.900 -81.940 -20.665 1.00 135.54 ? 891  ARG A NE  1 
ATOM   4708 C  CZ  . ARG A 1 628 ? -26.611 -82.475 -19.479 1.00 135.51 ? 891  ARG A CZ  1 
ATOM   4709 N  NH1 . ARG A 1 628 ? -26.502 -81.721 -18.396 1.00 141.53 ? 891  ARG A NH1 1 
ATOM   4710 N  NH2 . ARG A 1 628 ? -26.417 -83.777 -19.380 1.00 131.92 ? 891  ARG A NH2 1 
HETATM 4711 ZN ZN  . ZN  B 2 .   ? -6.584  -55.727 -23.817 1.00 21.91  2 1001 ZN  A ZN  1 
HETATM 4712 ZN ZN  . ZN  C 2 .   ? -25.968 -14.884 -13.271 1.00 49.81  2 1002 ZN  A ZN  1 
HETATM 4713 O  O1  . MES D 3 .   ? -28.399 -58.556 -0.848  0.41 23.64  ? 1003 MES A O1  1 
HETATM 4714 C  C2  . MES D 3 .   ? -28.040 -58.777 0.507   0.41 33.36  ? 1003 MES A C2  1 
HETATM 4715 C  C3  . MES D 3 .   ? -26.659 -58.248 0.800   0.41 34.50  ? 1003 MES A C3  1 
HETATM 4716 N  N4  . MES D 3 .   ? -25.662 -58.902 -0.101  0.41 23.68  ? 1003 MES A N4  1 
HETATM 4717 C  C5  . MES D 3 .   ? -26.086 -58.727 -1.524  0.41 23.82  ? 1003 MES A C5  1 
HETATM 4718 C  C6  . MES D 3 .   ? -27.494 -59.233 -1.706  0.41 24.67  ? 1003 MES A C6  1 
HETATM 4719 C  C7  . MES D 3 .   ? -24.275 -58.376 0.128   0.41 35.22  ? 1003 MES A C7  1 
HETATM 4720 C  C8  . MES D 3 .   ? -23.216 -59.192 -0.583  0.41 23.95  ? 1003 MES A C8  1 
HETATM 4721 S  S   . MES D 3 .   ? -21.569 -58.574 -0.325  0.41 14.94  ? 1003 MES A S   1 
HETATM 4722 O  O1S . MES D 3 .   ? -21.325 -58.668 1.080   0.41 26.10  ? 1003 MES A O1S 1 
HETATM 4723 O  O2S . MES D 3 .   ? -20.711 -59.420 -1.098  0.41 33.87  ? 1003 MES A O2S 1 
HETATM 4724 O  O3S . MES D 3 .   ? -21.568 -57.221 -0.794  0.41 412.78 ? 1003 MES A O3S 1 
HETATM 4725 S  S   . DMS E 4 .   ? -26.079 -62.428 -22.259 0.41 98.41  ? 1004 DMS A S   1 
HETATM 4726 O  O   . DMS E 4 .   ? -25.777 -61.678 -23.521 0.41 91.95  ? 1004 DMS A O   1 
HETATM 4727 C  C1  . DMS E 4 .   ? -27.730 -61.973 -21.780 0.41 99.24  ? 1004 DMS A C1  1 
HETATM 4728 C  C2  . DMS E 4 .   ? -25.224 -61.573 -20.960 0.41 97.76  ? 1004 DMS A C2  1 
HETATM 4729 S  S   . DMS F 4 .   ? -22.875 -48.554 -16.559 0.41 48.76  ? 1005 DMS A S   1 
HETATM 4730 O  O   . DMS F 4 .   ? -24.104 -48.131 -17.306 0.41 43.79  ? 1005 DMS A O   1 
HETATM 4731 C  C1  . DMS F 4 .   ? -21.512 -47.837 -17.435 0.41 48.57  ? 1005 DMS A C1  1 
HETATM 4732 C  C2  . DMS F 4 .   ? -22.586 -50.235 -16.990 0.41 47.84  ? 1005 DMS A C2  1 
HETATM 4733 C  C1  . PEG G 5 .   ? -31.173 -47.257 -25.104 0.41 51.73  ? 1006 PEG A C1  1 
HETATM 4734 O  O1  . PEG G 5 .   ? -30.220 -47.470 -26.130 0.41 52.61  ? 1006 PEG A O1  1 
HETATM 4735 C  C2  . PEG G 5 .   ? -30.649 -46.373 -24.011 0.41 52.30  ? 1006 PEG A C2  1 
HETATM 4736 O  O2  . PEG G 5 .   ? -31.417 -46.548 -22.823 0.41 50.00  ? 1006 PEG A O2  1 
HETATM 4737 C  C3  . PEG G 5 .   ? -31.480 -45.382 -22.002 0.41 51.05  ? 1006 PEG A C3  1 
HETATM 4738 C  C4  . PEG G 5 .   ? -30.136 -45.075 -21.402 0.41 49.26  ? 1006 PEG A C4  1 
HETATM 4739 O  O4  . PEG G 5 .   ? -30.232 -44.479 -20.117 0.41 51.64  ? 1006 PEG A O4  1 
HETATM 4740 P  P   . PO4 H 6 .   ? -4.613  -40.701 -23.554 0.41 32.75  ? 1007 PO4 A P   1 
HETATM 4741 O  O1  . PO4 H 6 .   ? -3.098  -41.139 -23.335 0.41 31.72  ? 1007 PO4 A O1  1 
HETATM 4742 O  O2  . PO4 H 6 .   ? -4.740  -39.290 -23.028 0.41 35.46  ? 1007 PO4 A O2  1 
HETATM 4743 O  O3  . PO4 H 6 .   ? -4.974  -40.767 -25.066 0.41 30.66  ? 1007 PO4 A O3  1 
HETATM 4744 O  O4  . PO4 H 6 .   ? -5.575  -41.608 -22.789 0.41 29.32  ? 1007 PO4 A O4  1 
HETATM 4745 P  P   . PO4 I 6 .   ? -17.170 -9.687  -27.866 0.41 66.38  ? 1008 PO4 A P   1 
HETATM 4746 O  O1  . PO4 I 6 .   ? -17.551 -10.379 -26.563 0.41 57.59  ? 1008 PO4 A O1  1 
HETATM 4747 O  O2  . PO4 I 6 .   ? -15.727 -9.182  -27.787 0.41 63.68  ? 1008 PO4 A O2  1 
HETATM 4748 O  O3  . PO4 I 6 .   ? -17.287 -10.682 -29.011 0.41 66.55  ? 1008 PO4 A O3  1 
HETATM 4749 O  O4  . PO4 I 6 .   ? -18.117 -8.504  -28.114 0.41 64.70  ? 1008 PO4 A O4  1 
HETATM 4750 C  C1  . PEG J 5 .   ? -16.699 -44.107 -41.020 0.41 45.90  ? 1009 PEG A C1  1 
HETATM 4751 O  O1  . PEG J 5 .   ? -18.087 -44.298 -41.200 0.41 42.04  ? 1009 PEG A O1  1 
HETATM 4752 C  C2  . PEG J 5 .   ? -15.890 -44.697 -42.131 0.41 45.83  ? 1009 PEG A C2  1 
HETATM 4753 O  O2  . PEG J 5 .   ? -16.351 -46.011 -42.425 0.41 47.96  ? 1009 PEG A O2  1 
HETATM 4754 C  C3  . PEG J 5 .   ? -15.799 -46.534 -43.630 0.41 49.06  ? 1009 PEG A C3  1 
HETATM 4755 C  C4  . PEG J 5 .   ? -16.233 -47.959 -43.818 0.41 48.92  ? 1009 PEG A C4  1 
HETATM 4756 O  O4  . PEG J 5 .   ? -15.336 -48.702 -44.632 0.41 47.74  ? 1009 PEG A O4  1 
HETATM 4757 C  C4  . X0S K 7 .   ? -2.498  -68.827 -20.788 0.41 44.64  ? 1010 X0S A C4  1 
HETATM 4758 C  C5  . X0S K 7 .   ? -2.489  -70.216 -20.829 0.41 47.15  ? 1010 X0S A C5  1 
HETATM 4759 C  C6  . X0S K 7 .   ? -1.287  -70.884 -21.088 0.41 46.61  ? 1010 X0S A C6  1 
HETATM 4760 C  C7  . X0S K 7 .   ? -3.970  -71.456 -17.908 0.41 51.70  ? 1010 X0S A C7  1 
HETATM 4761 N  N1  . X0S K 7 .   ? -3.796  -72.016 -19.239 0.41 51.51  ? 1010 X0S A N1  1 
HETATM 4762 C  C3  . X0S K 7 .   ? -1.323  -68.122 -20.993 0.41 47.03  ? 1010 X0S A C3  1 
HETATM 4763 C  C1  . X0S K 7 .   ? -0.116  -70.169 -21.287 0.41 45.25  ? 1010 X0S A C1  1 
HETATM 4764 C  C2  . X0S K 7 .   ? -0.143  -68.787 -21.234 0.41 44.73  ? 1010 X0S A C2  1 
HETATM 4765 O  O1  . X0S K 7 .   ? -4.988  -70.081 -20.133 0.41 52.83  ? 1010 X0S A O1  1 
HETATM 4766 O  O2  . X0S K 7 .   ? -4.278  -71.919 -21.630 0.41 56.00  ? 1010 X0S A O2  1 
HETATM 4767 S  S1  . X0S K 7 .   ? -4.018  -71.060 -20.514 0.41 53.26  ? 1010 X0S A S1  1 
HETATM 4768 CL CL1 . X0S K 7 .   ? -1.215  -72.612 -21.157 0.41 50.17  ? 1010 X0S A CL1 1 
HETATM 4769 C  C4  A X0S L 7 .   ? -11.262 -71.368 -18.574 0.20 33.84  ? 1011 X0S A C4  1 
HETATM 4770 C  C4  B X0S L 7 .   ? -10.014 -71.829 -18.095 0.21 44.13  ? 1011 X0S A C4  1 
HETATM 4771 C  C5  A X0S L 7 .   ? -10.070 -71.820 -18.026 0.20 35.40  ? 1011 X0S A C5  1 
HETATM 4772 C  C5  B X0S L 7 .   ? -10.053 -71.517 -19.447 0.21 44.12  ? 1011 X0S A C5  1 
HETATM 4773 C  C6  A X0S L 7 .   ? -8.970  -72.027 -18.872 0.20 36.27  ? 1011 X0S A C6  1 
HETATM 4774 C  C6  B X0S L 7 .   ? -8.865  -71.514 -20.183 0.21 39.88  ? 1011 X0S A C6  1 
HETATM 4775 C  C7  A X0S L 7 .   ? -10.923 -74.576 -16.531 0.20 37.05  ? 1011 X0S A C7  1 
HETATM 4776 C  C7  B X0S L 7 .   ? -13.413 -73.088 -20.253 0.21 48.30  ? 1011 X0S A C7  1 
HETATM 4777 N  N1  A X0S L 7 .   ? -9.865  -73.691 -16.049 0.20 36.95  ? 1011 X0S A N1  1 
HETATM 4778 N  N1  B X0S L 7 .   ? -12.749 -72.060 -19.459 0.21 49.19  ? 1011 X0S A N1  1 
HETATM 4779 C  C3  A X0S L 7 .   ? -11.348 -71.093 -19.929 0.20 34.92  ? 1011 X0S A C3  1 
HETATM 4780 C  C3  B X0S L 7 .   ? -8.807  -72.137 -17.492 0.21 41.32  ? 1011 X0S A C3  1 
HETATM 4781 C  C1  A X0S L 7 .   ? -9.067  -71.752 -20.230 0.20 34.89  ? 1011 X0S A C1  1 
HETATM 4782 C  C1  B X0S L 7 .   ? -7.663  -71.825 -19.571 0.21 40.05  ? 1011 X0S A C1  1 
HETATM 4783 C  C2  A X0S L 7 .   ? -10.258 -71.278 -20.749 0.20 34.11  ? 1011 X0S A C2  1 
HETATM 4784 C  C2  B X0S L 7 .   ? -7.644  -72.136 -18.223 0.21 41.04  ? 1011 X0S A C2  1 
HETATM 4785 O  O1  A X0S L 7 .   ? -8.815  -71.497 -15.775 0.20 33.68  ? 1011 X0S A O1  1 
HETATM 4786 O  O1  B X0S L 7 .   ? -11.942 -69.781 -19.858 0.21 50.29  ? 1011 X0S A O1  1 
HETATM 4787 O  O2  A X0S L 7 .   ? -11.273 -71.722 -15.693 0.20 35.30  ? 1011 X0S A O2  1 
HETATM 4788 O  O2  B X0S L 7 .   ? -11.551 -71.567 -21.523 0.21 52.13  ? 1011 X0S A O2  1 
HETATM 4789 S  S1  A X0S L 7 .   ? -10.016 -72.098 -16.264 0.20 34.64  ? 1011 X0S A S1  1 
HETATM 4790 S  S1  B X0S L 7 .   ? -11.628 -71.144 -20.160 0.21 49.62  ? 1011 X0S A S1  1 
HETATM 4791 CL CL1 A X0S L 7 .   ? -7.471  -72.665 -18.280 0.20 36.12  ? 1011 X0S A CL1 1 
HETATM 4792 CL CL1 B X0S L 7 .   ? -8.856  -71.120 -21.871 0.21 32.41  ? 1011 X0S A CL1 1 
HETATM 4793 CL CL  . CL  M 8 .   ? 3.959   -49.321 -29.854 0.41 18.04  ? 1012 CL  A CL  1 
HETATM 4794 O  O   . HOH N 9 .   ? -21.754 -43.215 -2.056  0.41 34.04  ? 1101 HOH A O   1 
HETATM 4795 O  O   . HOH N 9 .   ? -5.354  -59.153 -29.476 0.41 27.96  ? 1102 HOH A O   1 
HETATM 4796 O  O   . HOH N 9 .   ? -31.659 -52.385 -28.482 0.41 46.61  ? 1103 HOH A O   1 
HETATM 4797 O  O   . HOH N 9 .   ? -5.186  -60.850 -1.144  0.41 22.10  ? 1104 HOH A O   1 
HETATM 4798 O  O   . HOH N 9 .   ? -34.867 -20.784 -24.024 0.41 30.99  ? 1105 HOH A O   1 
HETATM 4799 O  O   . HOH N 9 .   ? -19.658 -27.314 -39.753 0.41 18.99  ? 1106 HOH A O   1 
HETATM 4800 O  O   . HOH N 9 .   ? -12.455 -70.480 -23.323 0.41 21.36  ? 1107 HOH A O   1 
HETATM 4801 O  O   . HOH N 9 .   ? 5.908   -45.119 -35.963 0.41 16.47  ? 1108 HOH A O   1 
HETATM 4802 O  O   . HOH N 9 .   ? -22.931 -33.727 -37.734 0.41 24.32  ? 1109 HOH A O   1 
HETATM 4803 O  O   . HOH N 9 .   ? 1.274   -21.536 -45.089 0.41 30.70  ? 1110 HOH A O   1 
HETATM 4804 O  O   . HOH N 9 .   ? 15.541  -33.162 -21.906 0.42 37.35  ? 1111 HOH A O   1 
HETATM 4805 O  O   . HOH N 9 .   ? -42.330 -63.914 -18.450 0.41 29.99  ? 1112 HOH A O   1 
HETATM 4806 O  O   . HOH N 9 .   ? -9.609  -21.819 -26.328 0.41 26.30  ? 1113 HOH A O   1 
HETATM 4807 O  O   . HOH N 9 .   ? 6.514   -35.211 -43.779 0.41 22.39  ? 1114 HOH A O   1 
HETATM 4808 O  O   . HOH N 9 .   ? -33.832 -47.754 -3.312  0.41 36.65  ? 1115 HOH A O   1 
HETATM 4809 O  O   . HOH N 9 .   ? -0.407  -31.624 -23.004 0.41 28.38  ? 1116 HOH A O   1 
HETATM 4810 O  O   . HOH N 9 .   ? -13.794 -49.691 -30.021 0.41 25.77  ? 1117 HOH A O   1 
HETATM 4811 O  O   . HOH N 9 .   ? -32.837 -63.577 -15.188 0.41 29.17  ? 1118 HOH A O   1 
HETATM 4812 O  O   . HOH N 9 .   ? -22.335 -32.093 -39.596 0.41 27.51  ? 1119 HOH A O   1 
HETATM 4813 O  O   . HOH N 9 .   ? 4.242   -26.973 -29.051 0.42 35.48  ? 1120 HOH A O   1 
HETATM 4814 O  O   . HOH N 9 .   ? 6.167   -33.345 -37.332 0.41 34.79  ? 1121 HOH A O   1 
HETATM 4815 O  O   . HOH N 9 .   ? -8.812  -59.919 -13.305 0.41 24.03  ? 1122 HOH A O   1 
HETATM 4816 O  O   . HOH N 9 .   ? -38.367 -61.817 -14.188 0.41 22.67  ? 1123 HOH A O   1 
HETATM 4817 O  O   . HOH N 9 .   ? -10.889 -48.285 -39.191 0.41 24.56  ? 1124 HOH A O   1 
HETATM 4818 O  O   . HOH N 9 .   ? -20.727 -29.501 -25.018 1.00 44.44  ? 1125 HOH A O   1 
HETATM 4819 O  O   . HOH N 9 .   ? -40.338 -62.253 -11.501 0.41 23.09  ? 1126 HOH A O   1 
HETATM 4820 O  O   . HOH N 9 .   ? -6.655  -20.437 -26.720 0.41 33.47  ? 1127 HOH A O   1 
HETATM 4821 O  O   . HOH N 9 .   ? -30.539 -64.913 -27.197 0.41 27.64  ? 1128 HOH A O   1 
HETATM 4822 O  O   . HOH N 9 .   ? 11.304  -35.725 -33.582 0.41 27.99  ? 1129 HOH A O   1 
HETATM 4823 O  O   . HOH N 9 .   ? 6.012   -32.002 -18.906 0.41 28.64  ? 1130 HOH A O   1 
HETATM 4824 O  O   . HOH N 9 .   ? 5.214   -30.084 -21.202 0.41 26.33  ? 1131 HOH A O   1 
HETATM 4825 O  O   . HOH N 9 .   ? -1.732  -41.928 -21.397 1.00 58.53  ? 1132 HOH A O   1 
HETATM 4826 O  O   . HOH N 9 .   ? -18.911 -70.490 -8.456  0.41 21.24  ? 1133 HOH A O   1 
HETATM 4827 O  O   . HOH N 9 .   ? -26.541 -25.336 -33.077 0.41 16.78  ? 1134 HOH A O   1 
HETATM 4828 O  O   . HOH N 9 .   ? -4.104  -57.892 -10.083 0.41 17.14  ? 1135 HOH A O   1 
HETATM 4829 O  O   . HOH N 9 .   ? -7.704  -43.077 -42.973 0.41 22.09  ? 1136 HOH A O   1 
HETATM 4830 O  O   . HOH N 9 .   ? -17.159 -52.189 -14.942 0.41 23.88  ? 1137 HOH A O   1 
HETATM 4831 O  O   . HOH N 9 .   ? -7.874  -47.387 -17.856 0.42 44.79  ? 1138 HOH A O   1 
HETATM 4832 O  O   . HOH N 9 .   ? -14.814 -17.457 -36.738 0.41 26.48  ? 1139 HOH A O   1 
HETATM 4833 O  O   . HOH N 9 .   ? -14.686 -48.484 -18.398 0.41 28.04  ? 1140 HOH A O   1 
HETATM 4834 O  O   . HOH N 9 .   ? -42.860 -62.525 -14.725 0.41 26.62  ? 1141 HOH A O   1 
HETATM 4835 O  O   . HOH N 9 .   ? 11.829  -36.972 -19.576 0.44 32.83  ? 1142 HOH A O   1 
HETATM 4836 O  O   . HOH N 9 .   ? -30.021 -61.747 -24.005 0.41 45.26  ? 1143 HOH A O   1 
HETATM 4837 O  O   . HOH N 9 .   ? -31.849 -71.146 -8.908  0.41 28.61  ? 1144 HOH A O   1 
HETATM 4838 O  O   . HOH N 9 .   ? -13.992 -52.640 -5.771  0.41 28.15  ? 1145 HOH A O   1 
HETATM 4839 O  O   . HOH N 9 .   ? -4.182  -55.112 -12.166 0.41 25.82  ? 1146 HOH A O   1 
HETATM 4840 O  O   . HOH N 9 .   ? -22.837 -49.863 -34.586 0.41 28.37  ? 1147 HOH A O   1 
HETATM 4841 O  O   . HOH N 9 .   ? -12.136 -37.355 -39.565 0.41 16.07  ? 1148 HOH A O   1 
HETATM 4842 O  O   . HOH N 9 .   ? -13.353 -69.550 -6.381  0.41 30.18  ? 1149 HOH A O   1 
HETATM 4843 O  O   . HOH N 9 .   ? -5.410  -15.119 -28.550 0.41 69.29  ? 1150 HOH A O   1 
HETATM 4844 O  O   . HOH N 9 .   ? -37.817 -56.017 -24.057 0.41 35.21  ? 1151 HOH A O   1 
HETATM 4845 O  O   . HOH N 9 .   ? -13.785 -74.838 -13.992 0.41 17.72  ? 1152 HOH A O   1 
HETATM 4846 O  O   . HOH N 9 .   ? -16.870 -32.668 -18.365 0.41 26.65  ? 1153 HOH A O   1 
HETATM 4847 O  O   . HOH N 9 .   ? -32.974 -14.782 -9.461  0.41 25.79  ? 1154 HOH A O   1 
HETATM 4848 O  O   . HOH N 9 .   ? -27.898 -16.577 -32.243 0.41 47.56  ? 1155 HOH A O   1 
HETATM 4849 O  O   . HOH N 9 .   ? -42.665 -63.433 -5.282  0.41 32.85  ? 1156 HOH A O   1 
HETATM 4850 O  O   . HOH N 9 .   ? -15.459 -54.854 -39.802 0.41 39.86  ? 1157 HOH A O   1 
HETATM 4851 O  O   . HOH N 9 .   ? -26.166 -72.092 -3.812  0.41 28.52  ? 1158 HOH A O   1 
HETATM 4852 O  O   . HOH N 9 .   ? -12.457 -58.584 0.000   0.41 27.46  ? 1159 HOH A O   1 
HETATM 4853 O  O   . HOH N 9 .   ? -29.326 -70.721 -13.564 0.41 45.68  ? 1160 HOH A O   1 
HETATM 4854 O  O   . HOH N 9 .   ? -32.002 -58.214 -21.846 0.41 32.40  ? 1161 HOH A O   1 
HETATM 4855 O  O   . HOH N 9 .   ? -5.483  -33.452 -18.167 0.41 26.90  ? 1162 HOH A O   1 
HETATM 4856 O  O   . HOH N 9 .   ? -29.704 -63.973 -35.584 0.41 36.43  ? 1163 HOH A O   1 
HETATM 4857 O  O   . HOH N 9 .   ? -17.460 -32.004 -42.228 0.41 27.64  ? 1164 HOH A O   1 
HETATM 4858 O  O   . HOH N 9 .   ? -36.245 -58.933 -2.672  0.41 29.46  ? 1165 HOH A O   1 
HETATM 4859 O  O   . HOH N 9 .   ? -8.418  -17.172 -38.860 0.41 26.71  ? 1166 HOH A O   1 
HETATM 4860 O  O   . HOH N 9 .   ? -4.189  -61.775 -15.066 0.41 23.93  ? 1167 HOH A O   1 
HETATM 4861 O  O   . HOH N 9 .   ? -38.400 -68.302 -8.639  0.41 29.33  ? 1168 HOH A O   1 
HETATM 4862 O  O   . HOH N 9 .   ? -14.841 -51.252 -44.180 0.41 34.75  ? 1169 HOH A O   1 
HETATM 4863 O  O   . HOH N 9 .   ? -22.018 -47.552 -9.846  0.41 31.08  ? 1170 HOH A O   1 
HETATM 4864 O  O   . HOH N 9 .   ? -32.081 -60.923 -18.912 0.41 41.79  ? 1171 HOH A O   1 
HETATM 4865 O  O   . HOH N 9 .   ? -17.679 -62.499 -44.939 0.41 30.92  ? 1172 HOH A O   1 
HETATM 4866 O  O   . HOH N 9 .   ? -22.732 -51.664 -9.234  0.41 19.08  ? 1173 HOH A O   1 
HETATM 4867 O  O   . HOH N 9 .   ? 1.864   -40.843 -26.543 0.41 46.98  ? 1174 HOH A O   1 
HETATM 4868 O  O   . HOH N 9 .   ? 1.312   -33.032 -39.149 0.41 23.68  ? 1175 HOH A O   1 
HETATM 4869 O  O   . HOH N 9 .   ? -39.712 -61.947 -4.190  0.41 41.47  ? 1176 HOH A O   1 
HETATM 4870 O  O   . HOH N 9 .   ? -28.497 -50.655 0.221   0.41 28.05  ? 1177 HOH A O   1 
HETATM 4871 O  O   . HOH N 9 .   ? -22.958 -66.121 -38.486 0.41 33.10  ? 1178 HOH A O   1 
HETATM 4872 O  O   . HOH N 9 .   ? -18.167 -62.874 -2.799  0.41 18.84  ? 1179 HOH A O   1 
HETATM 4873 O  O   . HOH N 9 .   ? -10.993 -62.755 -18.850 0.42 15.57  ? 1180 HOH A O   1 
HETATM 4874 O  O   . HOH N 9 .   ? -22.569 -20.766 -37.636 0.41 22.69  ? 1181 HOH A O   1 
HETATM 4875 O  O   . HOH N 9 .   ? -17.610 -66.852 -37.389 0.41 47.25  ? 1182 HOH A O   1 
HETATM 4876 O  O   . HOH N 9 .   ? -15.204 -35.529 -29.246 0.41 13.79  ? 1183 HOH A O   1 
HETATM 4877 O  O   . HOH N 9 .   ? -2.699  -58.442 -27.411 0.41 27.27  ? 1184 HOH A O   1 
HETATM 4878 O  O   . HOH N 9 .   ? -26.343 -51.163 -3.358  0.41 45.07  ? 1185 HOH A O   1 
HETATM 4879 O  O   . HOH N 9 .   ? -30.609 -57.081 -34.120 0.41 26.30  ? 1186 HOH A O   1 
HETATM 4880 O  O   . HOH N 9 .   ? -17.616 -41.829 -37.415 0.41 30.70  ? 1187 HOH A O   1 
HETATM 4881 O  O   . HOH N 9 .   ? -4.847  -33.901 -21.250 0.41 31.49  ? 1188 HOH A O   1 
HETATM 4882 O  O   . HOH N 9 .   ? 7.761   -43.297 -36.547 1.00 46.60  ? 1189 HOH A O   1 
HETATM 4883 O  O   . HOH N 9 .   ? 4.079   -28.868 -44.238 0.41 22.11  ? 1190 HOH A O   1 
HETATM 4884 O  O   . HOH N 9 .   ? -42.702 -66.897 -9.301  0.41 39.97  ? 1191 HOH A O   1 
HETATM 4885 O  O   . HOH N 9 .   ? -22.459 -29.921 -14.338 0.41 49.16  ? 1192 HOH A O   1 
HETATM 4886 O  O   . HOH N 9 .   ? -3.426  -20.843 -24.289 0.41 38.24  ? 1193 HOH A O   1 
HETATM 4887 O  O   . HOH N 9 .   ? 7.417   -49.445 -30.753 0.41 32.90  ? 1194 HOH A O   1 
HETATM 4888 O  O   . HOH N 9 .   ? -22.331 -66.665 -23.417 0.41 32.25  ? 1195 HOH A O   1 
HETATM 4889 O  O   . HOH N 9 .   ? -15.004 -71.201 -18.235 0.41 29.24  ? 1196 HOH A O   1 
HETATM 4890 O  O   . HOH N 9 .   ? 7.263   -28.799 -43.614 0.41 28.84  ? 1197 HOH A O   1 
HETATM 4891 O  O   . HOH N 9 .   ? -9.536  -39.196 -43.466 0.41 39.36  ? 1198 HOH A O   1 
HETATM 4892 O  O   . HOH N 9 .   ? -35.584 -67.033 -0.680  0.41 15.85  ? 1199 HOH A O   1 
HETATM 4893 O  O   . HOH N 9 .   ? -4.874  -49.342 -28.457 0.41 19.82  ? 1200 HOH A O   1 
HETATM 4894 O  O   . HOH N 9 .   ? -9.969  -65.128 -33.095 0.41 28.37  ? 1201 HOH A O   1 
HETATM 4895 O  O   . HOH N 9 .   ? -27.224 -16.044 -20.500 0.41 35.51  ? 1202 HOH A O   1 
HETATM 4896 O  O   . HOH N 9 .   ? -4.444  -54.175 -28.099 0.41 25.14  ? 1203 HOH A O   1 
HETATM 4897 O  O   . HOH N 9 .   ? 10.860  -40.756 -37.799 0.44 26.27  ? 1204 HOH A O   1 
HETATM 4898 O  O   . HOH N 9 .   ? 3.663   -43.294 -43.466 0.41 28.16  ? 1205 HOH A O   1 
HETATM 4899 O  O   . HOH N 9 .   ? -22.880 -8.147  -12.568 0.41 31.24  ? 1206 HOH A O   1 
HETATM 4900 O  O   . HOH N 9 .   ? -17.714 -57.908 -43.668 0.41 26.79  ? 1207 HOH A O   1 
HETATM 4901 O  O   . HOH N 9 .   ? -19.234 -38.390 -33.694 0.41 27.38  ? 1208 HOH A O   1 
HETATM 4902 O  O   . HOH N 9 .   ? 7.705   -46.716 -29.687 0.41 54.52  ? 1209 HOH A O   1 
HETATM 4903 O  O   . HOH N 9 .   ? -15.939 -66.285 -34.270 0.41 84.74  ? 1210 HOH A O   1 
HETATM 4904 O  O   . HOH N 9 .   ? -38.932 -55.205 -18.777 0.41 18.55  ? 1211 HOH A O   1 
HETATM 4905 O  O   . HOH N 9 .   ? 2.523   -44.630 -41.110 0.41 23.17  ? 1212 HOH A O   1 
HETATM 4906 O  O   . HOH N 9 .   ? 10.526  -38.906 -29.905 0.41 28.30  ? 1213 HOH A O   1 
HETATM 4907 O  O   . HOH N 9 .   ? 3.152   -50.991 -27.112 0.41 29.10  ? 1214 HOH A O   1 
HETATM 4908 O  O   . HOH N 9 .   ? 0.188   -33.646 -28.154 0.41 14.19  ? 1215 HOH A O   1 
HETATM 4909 O  O   . HOH N 9 .   ? -14.294 -57.056 -1.624  0.41 9.34   ? 1216 HOH A O   1 
HETATM 4910 O  O   . HOH N 9 .   ? -32.292 -19.739 -30.869 0.41 29.99  ? 1217 HOH A O   1 
HETATM 4911 O  O   . HOH N 9 .   ? -35.273 -50.731 -12.873 1.00 41.31  ? 1218 HOH A O   1 
HETATM 4912 O  O   . HOH N 9 .   ? -23.230 -28.071 -25.023 0.41 17.97  ? 1219 HOH A O   1 
HETATM 4913 O  O   . HOH N 9 .   ? -26.528 -32.203 -23.699 0.41 32.76  ? 1220 HOH A O   1 
HETATM 4914 O  O   . HOH N 9 .   ? -28.556 -24.153 -26.589 0.41 37.96  ? 1221 HOH A O   1 
HETATM 4915 O  O   . HOH N 9 .   ? 10.430  -27.139 -29.889 0.50 37.15  ? 1222 HOH A O   1 
HETATM 4916 O  O   . HOH N 9 .   ? -22.315 -74.628 -12.223 0.41 23.95  ? 1223 HOH A O   1 
HETATM 4917 O  O   . HOH N 9 .   ? -22.188 -66.468 -4.719  0.41 21.01  ? 1224 HOH A O   1 
HETATM 4918 O  O   . HOH N 9 .   ? -41.889 -59.119 -6.405  0.41 20.73  ? 1225 HOH A O   1 
HETATM 4919 O  O   . HOH N 9 .   ? -6.190  -50.489 -18.181 0.44 27.32  ? 1226 HOH A O   1 
HETATM 4920 O  O   . HOH N 9 .   ? -20.421 -67.880 -25.666 0.41 21.07  ? 1227 HOH A O   1 
HETATM 4921 O  O   . HOH N 9 .   ? -8.284  -64.975 -7.315  0.41 21.06  ? 1228 HOH A O   1 
HETATM 4922 O  O   . HOH N 9 .   ? -12.444 -54.495 -40.240 0.41 40.07  ? 1229 HOH A O   1 
HETATM 4923 O  O   . HOH N 9 .   ? -24.986 -53.531 -1.607  0.41 20.36  ? 1230 HOH A O   1 
HETATM 4924 O  O   . HOH N 9 .   ? -20.728 -31.783 -29.099 0.41 22.99  ? 1231 HOH A O   1 
HETATM 4925 O  O   . HOH N 9 .   ? -5.716  -59.665 -12.743 0.41 28.17  ? 1232 HOH A O   1 
HETATM 4926 O  O   . HOH N 9 .   ? 6.775   -27.584 -16.529 0.42 38.12  ? 1233 HOH A O   1 
HETATM 4927 O  O   . HOH N 9 .   ? 6.598   -19.298 -42.684 0.41 56.80  ? 1234 HOH A O   1 
HETATM 4928 O  O   . HOH N 9 .   ? -16.768 -68.291 -29.034 0.41 24.68  ? 1235 HOH A O   1 
HETATM 4929 O  O   . HOH N 9 .   ? 10.471  -30.124 -34.271 1.00 45.62  ? 1236 HOH A O   1 
HETATM 4930 O  O   . HOH N 9 .   ? 8.844   -40.502 -31.912 1.00 49.15  ? 1237 HOH A O   1 
HETATM 4931 O  O   . HOH N 9 .   ? 5.229   -38.565 -24.444 0.41 20.16  ? 1238 HOH A O   1 
HETATM 4932 O  O   . HOH N 9 .   ? -31.778 -60.480 -15.914 0.41 19.28  ? 1239 HOH A O   1 
HETATM 4933 O  O   . HOH N 9 .   ? -35.117 -67.595 -5.449  0.41 27.51  ? 1240 HOH A O   1 
HETATM 4934 O  O   . HOH N 9 .   ? -1.047  -33.274 -25.243 0.41 46.96  ? 1241 HOH A O   1 
HETATM 4935 O  O   . HOH N 9 .   ? -25.062 -69.239 -27.862 0.41 37.17  ? 1242 HOH A O   1 
HETATM 4936 O  O   . HOH N 9 .   ? -4.230  -65.616 -14.734 0.41 20.29  ? 1243 HOH A O   1 
HETATM 4937 O  O   . HOH N 9 .   ? -21.647 -65.427 -40.928 0.41 34.77  ? 1244 HOH A O   1 
HETATM 4938 O  O   . HOH N 9 .   ? -11.012 -23.430 -44.741 0.41 32.33  ? 1245 HOH A O   1 
HETATM 4939 O  O   . HOH N 9 .   ? -11.351 -43.755 -16.437 0.44 45.82  ? 1246 HOH A O   1 
HETATM 4940 O  O   . HOH N 9 .   ? -13.894 -50.159 -32.633 0.41 31.57  ? 1247 HOH A O   1 
HETATM 4941 O  O   . HOH N 9 .   ? -29.551 -59.736 -20.045 0.41 24.31  ? 1248 HOH A O   1 
HETATM 4942 O  O   . HOH N 9 .   ? -35.810 -59.279 -26.937 0.41 27.92  ? 1249 HOH A O   1 
HETATM 4943 O  O   . HOH N 9 .   ? -27.945 -47.972 -0.277  0.41 25.95  ? 1250 HOH A O   1 
HETATM 4944 O  O   . HOH N 9 .   ? -15.512 -55.528 -43.332 0.41 32.40  ? 1251 HOH A O   1 
HETATM 4945 O  O   . HOH N 9 .   ? -19.285 -20.559 -40.209 0.41 30.50  ? 1252 HOH A O   1 
HETATM 4946 O  O   . HOH N 9 .   ? -19.993 -66.021 -37.415 0.41 49.05  ? 1253 HOH A O   1 
HETATM 4947 O  O   . HOH N 9 .   ? -8.545  -64.324 -30.932 0.41 35.48  ? 1254 HOH A O   1 
HETATM 4948 O  O   . HOH N 9 .   ? -14.820 -64.647 -0.569  0.41 17.54  ? 1255 HOH A O   1 
HETATM 4949 O  O   . HOH N 9 .   ? -14.423 -57.990 -41.937 0.41 21.18  ? 1256 HOH A O   1 
HETATM 4950 O  O   . HOH N 9 .   ? -29.681 -36.322 -30.875 0.41 42.72  ? 1257 HOH A O   1 
HETATM 4951 O  O   . HOH N 9 .   ? -18.724 -65.576 -7.315  0.41 9.81   ? 1258 HOH A O   1 
HETATM 4952 O  O   . HOH N 9 .   ? -33.833 -57.633 -19.619 0.41 18.03  ? 1259 HOH A O   1 
HETATM 4953 O  O   . HOH N 9 .   ? -0.826  -11.228 -29.244 0.41 42.12  ? 1260 HOH A O   1 
HETATM 4954 O  O   . HOH N 9 .   ? -15.015 -54.592 -4.185  0.41 13.02  ? 1261 HOH A O   1 
HETATM 4955 O  O   . HOH N 9 .   ? -27.842 -17.958 -34.524 0.41 41.09  ? 1262 HOH A O   1 
HETATM 4956 O  O   . HOH N 9 .   ? -8.661  -40.479 -39.812 0.41 25.91  ? 1263 HOH A O   1 
HETATM 4957 O  O   . HOH N 9 .   ? -27.357 -57.251 -40.193 0.41 29.18  ? 1264 HOH A O   1 
HETATM 4958 O  O   . HOH N 9 .   ? -12.446 -66.979 -30.324 0.41 32.50  ? 1265 HOH A O   1 
HETATM 4959 O  O   . HOH N 9 .   ? -5.859  -68.881 -27.486 0.41 17.72  ? 1266 HOH A O   1 
HETATM 4960 O  O   . HOH N 9 .   ? -29.362 -70.996 -2.838  0.41 26.28  ? 1267 HOH A O   1 
HETATM 4961 O  O   . HOH N 9 .   ? -0.099  -64.134 -20.594 0.41 23.99  ? 1268 HOH A O   1 
HETATM 4962 O  O   . HOH N 9 .   ? -36.264 -51.742 -21.899 0.41 31.93  ? 1269 HOH A O   1 
HETATM 4963 O  O   . HOH N 9 .   ? -13.820 -54.017 -1.488  0.41 23.34  ? 1270 HOH A O   1 
HETATM 4964 O  O   . HOH N 9 .   ? -38.880 -57.636 -20.444 0.41 25.87  ? 1271 HOH A O   1 
HETATM 4965 O  O   . HOH N 9 .   ? -34.920 -63.620 0.493   0.41 13.15  ? 1272 HOH A O   1 
HETATM 4966 O  O   . HOH N 9 .   ? -37.180 -51.337 -5.162  0.41 26.60  ? 1273 HOH A O   1 
HETATM 4967 O  O   . HOH N 9 .   ? -27.386 -52.862 -42.227 0.41 27.29  ? 1274 HOH A O   1 
HETATM 4968 O  O   . HOH N 9 .   ? -24.231 -58.647 -46.618 0.41 22.32  ? 1275 HOH A O   1 
HETATM 4969 O  O   . HOH N 9 .   ? -15.967 -49.750 -16.366 0.41 20.12  ? 1276 HOH A O   1 
HETATM 4970 O  O   . HOH N 9 .   ? -0.579  -36.136 -28.362 0.41 22.28  ? 1277 HOH A O   1 
HETATM 4971 O  O   . HOH N 9 .   ? -28.527 -63.300 -24.859 0.41 33.05  ? 1278 HOH A O   1 
HETATM 4972 O  O   . HOH N 9 .   ? -20.335 -31.737 -26.688 1.00 35.52  ? 1279 HOH A O   1 
HETATM 4973 O  O   . HOH N 9 .   ? -19.304 -17.582 -11.288 0.41 25.86  ? 1280 HOH A O   1 
HETATM 4974 O  O   . HOH N 9 .   ? 3.465   -69.896 -21.120 0.41 26.01  ? 1281 HOH A O   1 
HETATM 4975 O  O   . HOH N 9 .   ? -34.838 -59.598 -29.441 0.41 34.16  ? 1282 HOH A O   1 
HETATM 4976 O  O   . HOH N 9 .   ? -7.611  -49.138 0.973   0.41 35.27  ? 1283 HOH A O   1 
HETATM 4977 O  O   . HOH N 9 .   ? -13.667 -32.595 -20.533 0.41 18.80  ? 1284 HOH A O   1 
HETATM 4978 O  O   . HOH N 9 .   ? -37.863 -53.025 -13.373 0.41 20.34  ? 1285 HOH A O   1 
HETATM 4979 O  O   . HOH N 9 .   ? -20.501 -47.216 -25.855 0.41 29.83  ? 1286 HOH A O   1 
HETATM 4980 O  O   . HOH N 9 .   ? -31.771 -71.948 -13.779 0.41 49.08  ? 1287 HOH A O   1 
HETATM 4981 O  O   . HOH N 9 .   ? -27.298 -26.694 -35.311 0.41 35.62  ? 1288 HOH A O   1 
HETATM 4982 O  O   . HOH N 9 .   ? -7.750  -62.336 -33.803 0.41 23.05  ? 1289 HOH A O   1 
HETATM 4983 O  O   . HOH N 9 .   ? -3.630  -56.451 -7.142  0.41 21.78  ? 1290 HOH A O   1 
HETATM 4984 O  O   . HOH N 9 .   ? -36.012 -54.975 -3.355  0.41 20.45  ? 1291 HOH A O   1 
HETATM 4985 O  O   . HOH N 9 .   ? -22.710 -44.560 -33.301 0.41 28.49  ? 1292 HOH A O   1 
HETATM 4986 O  O   . HOH N 9 .   ? -30.479 -67.100 -32.423 0.41 40.63  ? 1293 HOH A O   1 
HETATM 4987 O  O   . HOH N 9 .   ? -20.824 -70.577 -5.681  0.41 49.25  ? 1294 HOH A O   1 
HETATM 4988 O  O   . HOH N 9 .   ? -41.279 -58.584 -9.822  0.41 38.62  ? 1295 HOH A O   1 
HETATM 4989 O  O   . HOH N 9 .   ? 3.263   -38.285 -44.371 0.41 31.23  ? 1296 HOH A O   1 
HETATM 4990 O  O   . HOH N 9 .   ? -5.796  -49.030 -21.699 0.46 23.39  ? 1297 HOH A O   1 
HETATM 4991 O  O   . HOH N 9 .   ? 2.252   -40.357 -24.105 0.41 44.33  ? 1298 HOH A O   1 
HETATM 4992 O  O   . HOH N 9 .   ? -8.897  -27.584 -45.330 0.41 27.95  ? 1299 HOH A O   1 
HETATM 4993 O  O   . HOH N 9 .   ? -19.624 -38.875 -37.379 0.41 46.06  ? 1300 HOH A O   1 
HETATM 4994 O  O   . HOH N 9 .   ? 3.074   -64.419 -20.616 0.41 19.90  ? 1301 HOH A O   1 
HETATM 4995 O  O   . HOH N 9 .   ? -3.590  -71.554 -9.392  0.41 26.67  ? 1302 HOH A O   1 
HETATM 4996 O  O   . HOH N 9 .   ? -26.607 -28.143 -42.682 0.41 29.04  ? 1303 HOH A O   1 
HETATM 4997 O  O   . HOH N 9 .   ? -7.777  -37.708 -19.829 0.41 37.74  ? 1304 HOH A O   1 
HETATM 4998 O  O   . HOH N 9 .   ? -31.512 -45.843 -15.634 0.41 30.66  ? 1305 HOH A O   1 
HETATM 4999 O  O   . HOH N 9 .   ? -21.113 -44.070 -42.139 0.41 36.35  ? 1306 HOH A O   1 
HETATM 5000 O  O   . HOH N 9 .   ? -11.905 -47.077 3.914   0.44 28.23  ? 1307 HOH A O   1 
HETATM 5001 O  O   . HOH N 9 .   ? -4.843  -63.053 -4.180  0.41 23.02  ? 1308 HOH A O   1 
HETATM 5002 O  O   . HOH N 9 .   ? -1.302  -69.970 -17.283 0.41 29.20  ? 1309 HOH A O   1 
HETATM 5003 O  O   . HOH N 9 .   ? -25.729 -19.804 -38.834 0.41 24.64  ? 1310 HOH A O   1 
HETATM 5004 O  O   . HOH N 9 .   ? -40.064 -63.888 -2.368  0.41 23.07  ? 1311 HOH A O   1 
HETATM 5005 O  O   . HOH N 9 .   ? -15.613 -22.503 -18.701 0.41 32.59  ? 1312 HOH A O   1 
HETATM 5006 O  O   . HOH N 9 .   ? -4.738  -56.535 -31.240 0.41 25.51  ? 1313 HOH A O   1 
HETATM 5007 O  O   . HOH N 9 .   ? -6.069  -60.393 -35.529 0.41 33.98  ? 1314 HOH A O   1 
HETATM 5008 O  O   . HOH N 9 .   ? -3.966  -57.483 -13.493 0.41 21.32  ? 1315 HOH A O   1 
HETATM 5009 O  O   . HOH N 9 .   ? 3.454   -34.732 -14.227 0.41 29.62  ? 1316 HOH A O   1 
HETATM 5010 O  O   . HOH N 9 .   ? -33.921 -71.196 -17.758 0.41 25.91  ? 1317 HOH A O   1 
HETATM 5011 O  O   . HOH N 9 .   ? 3.200   -32.112 -37.677 0.41 22.60  ? 1318 HOH A O   1 
HETATM 5012 O  O   . HOH N 9 .   ? -29.499 -17.299 -20.823 0.41 68.03  ? 1319 HOH A O   1 
HETATM 5013 O  O   . HOH N 9 .   ? -4.272  -23.592 -26.206 0.41 34.10  ? 1320 HOH A O   1 
HETATM 5014 O  O   . HOH N 9 .   ? -29.347 -34.904 -29.124 0.41 42.00  ? 1321 HOH A O   1 
HETATM 5015 O  O   . HOH N 9 .   ? -23.836 -49.681 -41.671 0.41 24.00  ? 1322 HOH A O   1 
HETATM 5016 O  O   . HOH N 9 .   ? -8.593  -31.481 -15.371 0.41 30.06  ? 1323 HOH A O   1 
HETATM 5017 O  O   . HOH N 9 .   ? -0.651  -46.559 -43.067 0.41 43.40  ? 1324 HOH A O   1 
HETATM 5018 O  O   . HOH N 9 .   ? -32.648 -47.877 -18.881 0.41 36.09  ? 1325 HOH A O   1 
HETATM 5019 O  O   . HOH N 9 .   ? -34.260 -47.712 -15.357 0.41 31.86  ? 1326 HOH A O   1 
HETATM 5020 O  O   . HOH N 9 .   ? -34.120 -71.191 -9.630  0.41 32.17  ? 1327 HOH A O   1 
HETATM 5021 O  O   . HOH N 9 .   ? -40.002 -24.635 -26.464 1.00 52.85  ? 1328 HOH A O   1 
HETATM 5022 O  O   . HOH N 9 .   ? -16.798 -72.250 -22.288 0.41 44.56  ? 1329 HOH A O   1 
HETATM 5023 O  O   . HOH N 9 .   ? -4.499  -54.177 -19.577 0.42 19.94  ? 1330 HOH A O   1 
HETATM 5024 O  O   . HOH N 9 .   ? -6.918  -29.967 -13.669 0.41 51.70  ? 1331 HOH A O   1 
HETATM 5025 O  O   . HOH N 9 .   ? -37.319 -69.092 -11.718 0.41 30.91  ? 1332 HOH A O   1 
HETATM 5026 O  O   . HOH N 9 .   ? -13.018 -41.823 -21.297 0.44 48.50  ? 1333 HOH A O   1 
HETATM 5027 O  O   . HOH N 9 .   ? -0.391  -48.436 -36.872 0.41 26.05  ? 1334 HOH A O   1 
HETATM 5028 O  O   . HOH N 9 .   ? -5.635  -68.839 -6.731  0.41 36.77  ? 1335 HOH A O   1 
HETATM 5029 O  O   . HOH N 9 .   ? -17.653 -47.541 -15.639 0.41 25.41  ? 1336 HOH A O   1 
HETATM 5030 O  O   . HOH N 9 .   ? -9.873  -25.707 -12.509 0.41 41.81  ? 1337 HOH A O   1 
HETATM 5031 O  O   . HOH N 9 .   ? -3.137  -56.093 -29.316 0.41 22.63  ? 1338 HOH A O   1 
HETATM 5032 O  O   . HOH N 9 .   ? -28.382 -49.611 -31.085 0.41 27.98  ? 1339 HOH A O   1 
HETATM 5033 O  O   . HOH N 9 .   ? -10.734 -17.785 -40.286 0.41 25.20  ? 1340 HOH A O   1 
HETATM 5034 O  O   . HOH N 9 .   ? -23.274 -75.908 -9.580  0.41 27.56  ? 1341 HOH A O   1 
HETATM 5035 O  O   . HOH N 9 .   ? -18.227 -69.981 -25.465 0.41 38.47  ? 1342 HOH A O   1 
HETATM 5036 O  O   . HOH N 9 .   ? -5.299  -74.185 -16.852 0.41 36.71  ? 1343 HOH A O   1 
HETATM 5037 O  O   . HOH N 9 .   ? -13.589 -42.182 -39.062 0.41 43.12  ? 1344 HOH A O   1 
HETATM 5038 O  O   . HOH N 9 .   ? -14.740 -70.093 -22.267 0.41 40.60  ? 1345 HOH A O   1 
HETATM 5039 O  O   . HOH N 9 .   ? -27.185 -67.774 -27.913 0.41 27.58  ? 1346 HOH A O   1 
HETATM 5040 O  O   . HOH N 9 .   ? -2.600  -39.413 -45.819 0.41 28.52  ? 1347 HOH A O   1 
HETATM 5041 O  O   . HOH N 9 .   ? -26.923 -74.354 -5.384  0.41 29.67  ? 1348 HOH A O   1 
HETATM 5042 O  O   . HOH N 9 .   ? -4.962  -34.727 -14.632 0.41 37.93  ? 1349 HOH A O   1 
HETATM 5043 O  O   . HOH N 9 .   ? -15.941 -27.992 -46.173 0.41 52.43  ? 1350 HOH A O   1 
HETATM 5044 O  O   . HOH N 9 .   ? -28.858 -68.912 -23.687 0.41 39.27  ? 1351 HOH A O   1 
HETATM 5045 O  O   . HOH N 9 .   ? 7.631   -22.638 -23.033 0.42 37.94  ? 1352 HOH A O   1 
HETATM 5046 O  O   . HOH N 9 .   ? -24.948 -31.236 -40.746 0.41 31.78  ? 1353 HOH A O   1 
HETATM 5047 O  O   . HOH N 9 .   ? -16.427 -47.250 -11.299 0.41 33.72  ? 1354 HOH A O   1 
HETATM 5048 O  O   . HOH N 9 .   ? -17.822 -27.649 -44.324 0.41 37.20  ? 1355 HOH A O   1 
HETATM 5049 O  O   . HOH N 9 .   ? -2.592  -58.235 -24.924 0.41 50.04  ? 1356 HOH A O   1 
HETATM 5050 O  O   . HOH N 9 .   ? -19.457 -65.065 -2.296  0.41 27.58  ? 1357 HOH A O   1 
HETATM 5051 O  O   . HOH N 9 .   ? 0.126   -62.483 -17.800 0.41 27.12  ? 1358 HOH A O   1 
HETATM 5052 O  O   . HOH N 9 .   ? -41.577 -56.199 -13.608 0.41 25.30  ? 1359 HOH A O   1 
HETATM 5053 O  O   . HOH N 9 .   ? -38.853 -52.001 -20.400 0.41 28.32  ? 1360 HOH A O   1 
HETATM 5054 O  O   . HOH N 9 .   ? -15.916 -69.753 -5.977  0.41 25.72  ? 1361 HOH A O   1 
HETATM 5055 O  O   . HOH N 9 .   ? -9.433  -41.569 -42.498 0.41 46.45  ? 1362 HOH A O   1 
HETATM 5056 O  O   . HOH N 9 .   ? -28.993 -57.717 -37.349 0.41 43.47  ? 1363 HOH A O   1 
HETATM 5057 O  O   . HOH N 9 .   ? -1.802  -63.719 -15.218 0.41 36.63  ? 1364 HOH A O   1 
HETATM 5058 O  O   . HOH N 9 .   ? -12.762 -77.120 -12.930 0.41 34.14  ? 1365 HOH A O   1 
HETATM 5059 O  O   . HOH N 9 .   ? -34.357 -49.843 -10.353 0.41 23.71  ? 1366 HOH A O   1 
HETATM 5060 O  O   . HOH N 9 .   ? -19.015 -45.810 -9.313  0.41 32.04  ? 1367 HOH A O   1 
HETATM 5061 O  O   . HOH N 9 .   ? -23.518 -37.768 -33.489 0.41 30.91  ? 1368 HOH A O   1 
HETATM 5062 O  O   . HOH N 9 .   ? -3.162  -52.134 -5.095  0.41 32.84  ? 1369 HOH A O   1 
HETATM 5063 O  O   . HOH N 9 .   ? -2.412  -65.332 -13.341 0.41 36.79  ? 1370 HOH A O   1 
HETATM 5064 O  O   . HOH N 9 .   ? -11.476 -75.121 -27.634 0.41 49.23  ? 1371 HOH A O   1 
HETATM 5065 O  O   . HOH N 9 .   ? -2.212  -35.050 -13.105 0.41 65.52  ? 1372 HOH A O   1 
HETATM 5066 O  O   . HOH N 9 .   ? -10.160 -28.136 -11.925 0.41 31.25  ? 1373 HOH A O   1 
HETATM 5067 O  O   . HOH N 9 .   ? -15.938 -41.188 -39.222 0.41 49.68  ? 1374 HOH A O   1 
HETATM 5068 O  O   . HOH N 9 .   ? -8.931  -72.174 -26.517 0.41 24.10  ? 1375 HOH A O   1 
HETATM 5069 O  O   . HOH N 9 .   ? 5.139   -51.414 -31.582 0.41 34.33  ? 1376 HOH A O   1 
HETATM 5070 O  O   . HOH N 9 .   ? -0.961  -55.852 -13.870 0.41 41.58  ? 1377 HOH A O   1 
HETATM 5071 O  O   . HOH N 9 .   ? -36.026 -48.623 -14.049 1.00 49.78  ? 1378 HOH A O   1 
HETATM 5072 O  O   . HOH N 9 .   ? -19.448 -68.668 -4.408  0.41 33.21  ? 1379 HOH A O   1 
HETATM 5073 O  O   . HOH N 9 .   ? 0.000   -58.584 -27.313 0.41 117.68 ? 1380 HOH A O   1 
HETATM 5074 O  O   . HOH N 9 .   ? -12.148 -10.986 -33.781 0.41 30.07  ? 1381 HOH A O   1 
HETATM 5075 O  O   . HOH N 9 .   ? -17.987 -68.526 -6.388  0.41 22.06  ? 1382 HOH A O   1 
HETATM 5076 O  O   . HOH N 9 .   ? -2.774  -61.550 -5.541  0.41 32.94  ? 1383 HOH A O   1 
HETATM 5077 O  O   . HOH N 9 .   ? -38.293 -56.962 -5.043  0.41 41.44  ? 1384 HOH A O   1 
HETATM 5078 O  O   . HOH N 9 .   ? -2.380  -56.707 0.743   0.41 30.72  ? 1385 HOH A O   1 
HETATM 5079 O  O   . HOH N 9 .   ? -4.379  -60.958 -10.663 0.41 26.41  ? 1386 HOH A O   1 
HETATM 5080 O  O   . HOH N 9 .   ? -4.361  -66.540 -6.298  0.41 30.54  ? 1387 HOH A O   1 
HETATM 5081 O  O   . HOH N 9 .   ? -5.072  -64.195 -6.240  0.41 34.96  ? 1388 HOH A O   1 
HETATM 5082 O  O   . HOH N 9 .   ? -42.318 -62.541 -1.919  0.41 31.26  ? 1389 HOH A O   1 
HETATM 5083 O  O   . HOH N 9 .   ? -4.275  -63.043 -8.682  0.41 28.05  ? 1390 HOH A O   1 
# 
