data_9HVJ
# 
_entry.id   9HVJ 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9HVJ         pdb_00009hvj 10.2210/pdb9hvj/pdb 
WWPDB D_1292143717 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-03-12 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9HVJ 
_pdbx_database_status.recvd_initial_deposition_date   2024-12-29 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              gert.bange@synmikro.uni-marburg.de 
_pdbx_contact_author.name_first         Gert 
_pdbx_contact_author.name_last          Bange 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-7826-0932 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Jalomo-Khayrova, E.' 1 0000-0001-6363-341X 
'Bange, G.'           2 0000-0002-7826-0932 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Biorxiv 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2692-8205 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Specificities of Chemosensory Receptors in the Human Gut Microbiota.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1101/2025.02.11.637667 
_citation.pdbx_database_id_PubMed   39990360 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Xu, W.'              1 ?                   
primary 'Jalomo-Khayrova, E.' 2 ?                   
primary 'Gumerov, V.M.'       3 ?                   
primary 'Ross, P.A.'          4 ?                   
primary 'Kobel, T.S.'         5 ?                   
primary 'Schindler, D.'       6 0000-0001-7423-6540 
primary 'Bange, G.'           7 ?                   
primary 'Zhulin, I.B.'        8 0000-0002-6708-5323 
primary 'Sourjik, V.'         9 0000-0003-1053-9192 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Cache domain protein' 33859.504 1   ? ? ? ? 
2 non-polymer syn URACIL                 112.087   1   ? ? ? ? 
3 non-polymer syn 'ACETATE ION'          59.044    1   ? ? ? ? 
4 non-polymer syn 1,2-ETHANEDIOL         62.068    1   ? ? ? ? 
5 water       nat water                  18.015    265 ? ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Methyl-accepting chemotaxis protein McpC' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MGSSHHHHHHSSGLVPRGSHMSTSYEDSQQEMQLKCVSQSDELDTMMQNVSQSVEMVYSIAVAKLEHAASFRTSKDYVDT
YTKQMLPILMQSAQNTKGALTAYIRYNPEFTEPTSGLFLTRDNSDSEFESVTPTDFSMYDPSDVEHVGWYYIPVQNGKET
WMEPYLNSNIGVYMISYVIPIEVDGESIGIIGMDIDFSEFTDTIDSLSIFDSGYGFLVNESGKVMYHKDLEIGSNLADAD
SGLQSVVDALGNEQTEETAVSYTYQGKDKVMYYKTLENGMKFVLTAPKTELQEKSRQLAKQ
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MGSSHHHHHHSSGLVPRGSHMSTSYEDSQQEMQLKCVSQSDELDTMMQNVSQSVEMVYSIAVAKLEHAASFRTSKDYVDT
YTKQMLPILMQSAQNTKGALTAYIRYNPEFTEPTSGLFLTRDNSDSEFESVTPTDFSMYDPSDVEHVGWYYIPVQNGKET
WMEPYLNSNIGVYMISYVIPIEVDGESIGIIGMDIDFSEFTDTIDSLSIFDSGYGFLVNESGKVMYHKDLEIGSNLADAD
SGLQSVVDALGNEQTEETAVSYTYQGKDKVMYYKTLENGMKFVLTAPKTELQEKSRQLAKQ
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 URACIL         URA 
3 'ACETATE ION'  ACT 
4 1,2-ETHANEDIOL EDO 
5 water          HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   GLY n 
1 3   SER n 
1 4   SER n 
1 5   HIS n 
1 6   HIS n 
1 7   HIS n 
1 8   HIS n 
1 9   HIS n 
1 10  HIS n 
1 11  SER n 
1 12  SER n 
1 13  GLY n 
1 14  LEU n 
1 15  VAL n 
1 16  PRO n 
1 17  ARG n 
1 18  GLY n 
1 19  SER n 
1 20  HIS n 
1 21  MET n 
1 22  SER n 
1 23  THR n 
1 24  SER n 
1 25  TYR n 
1 26  GLU n 
1 27  ASP n 
1 28  SER n 
1 29  GLN n 
1 30  GLN n 
1 31  GLU n 
1 32  MET n 
1 33  GLN n 
1 34  LEU n 
1 35  LYS n 
1 36  CYS n 
1 37  VAL n 
1 38  SER n 
1 39  GLN n 
1 40  SER n 
1 41  ASP n 
1 42  GLU n 
1 43  LEU n 
1 44  ASP n 
1 45  THR n 
1 46  MET n 
1 47  MET n 
1 48  GLN n 
1 49  ASN n 
1 50  VAL n 
1 51  SER n 
1 52  GLN n 
1 53  SER n 
1 54  VAL n 
1 55  GLU n 
1 56  MET n 
1 57  VAL n 
1 58  TYR n 
1 59  SER n 
1 60  ILE n 
1 61  ALA n 
1 62  VAL n 
1 63  ALA n 
1 64  LYS n 
1 65  LEU n 
1 66  GLU n 
1 67  HIS n 
1 68  ALA n 
1 69  ALA n 
1 70  SER n 
1 71  PHE n 
1 72  ARG n 
1 73  THR n 
1 74  SER n 
1 75  LYS n 
1 76  ASP n 
1 77  TYR n 
1 78  VAL n 
1 79  ASP n 
1 80  THR n 
1 81  TYR n 
1 82  THR n 
1 83  LYS n 
1 84  GLN n 
1 85  MET n 
1 86  LEU n 
1 87  PRO n 
1 88  ILE n 
1 89  LEU n 
1 90  MET n 
1 91  GLN n 
1 92  SER n 
1 93  ALA n 
1 94  GLN n 
1 95  ASN n 
1 96  THR n 
1 97  LYS n 
1 98  GLY n 
1 99  ALA n 
1 100 LEU n 
1 101 THR n 
1 102 ALA n 
1 103 TYR n 
1 104 ILE n 
1 105 ARG n 
1 106 TYR n 
1 107 ASN n 
1 108 PRO n 
1 109 GLU n 
1 110 PHE n 
1 111 THR n 
1 112 GLU n 
1 113 PRO n 
1 114 THR n 
1 115 SER n 
1 116 GLY n 
1 117 LEU n 
1 118 PHE n 
1 119 LEU n 
1 120 THR n 
1 121 ARG n 
1 122 ASP n 
1 123 ASN n 
1 124 SER n 
1 125 ASP n 
1 126 SER n 
1 127 GLU n 
1 128 PHE n 
1 129 GLU n 
1 130 SER n 
1 131 VAL n 
1 132 THR n 
1 133 PRO n 
1 134 THR n 
1 135 ASP n 
1 136 PHE n 
1 137 SER n 
1 138 MET n 
1 139 TYR n 
1 140 ASP n 
1 141 PRO n 
1 142 SER n 
1 143 ASP n 
1 144 VAL n 
1 145 GLU n 
1 146 HIS n 
1 147 VAL n 
1 148 GLY n 
1 149 TRP n 
1 150 TYR n 
1 151 TYR n 
1 152 ILE n 
1 153 PRO n 
1 154 VAL n 
1 155 GLN n 
1 156 ASN n 
1 157 GLY n 
1 158 LYS n 
1 159 GLU n 
1 160 THR n 
1 161 TRP n 
1 162 MET n 
1 163 GLU n 
1 164 PRO n 
1 165 TYR n 
1 166 LEU n 
1 167 ASN n 
1 168 SER n 
1 169 ASN n 
1 170 ILE n 
1 171 GLY n 
1 172 VAL n 
1 173 TYR n 
1 174 MET n 
1 175 ILE n 
1 176 SER n 
1 177 TYR n 
1 178 VAL n 
1 179 ILE n 
1 180 PRO n 
1 181 ILE n 
1 182 GLU n 
1 183 VAL n 
1 184 ASP n 
1 185 GLY n 
1 186 GLU n 
1 187 SER n 
1 188 ILE n 
1 189 GLY n 
1 190 ILE n 
1 191 ILE n 
1 192 GLY n 
1 193 MET n 
1 194 ASP n 
1 195 ILE n 
1 196 ASP n 
1 197 PHE n 
1 198 SER n 
1 199 GLU n 
1 200 PHE n 
1 201 THR n 
1 202 ASP n 
1 203 THR n 
1 204 ILE n 
1 205 ASP n 
1 206 SER n 
1 207 LEU n 
1 208 SER n 
1 209 ILE n 
1 210 PHE n 
1 211 ASP n 
1 212 SER n 
1 213 GLY n 
1 214 TYR n 
1 215 GLY n 
1 216 PHE n 
1 217 LEU n 
1 218 VAL n 
1 219 ASN n 
1 220 GLU n 
1 221 SER n 
1 222 GLY n 
1 223 LYS n 
1 224 VAL n 
1 225 MET n 
1 226 TYR n 
1 227 HIS n 
1 228 LYS n 
1 229 ASP n 
1 230 LEU n 
1 231 GLU n 
1 232 ILE n 
1 233 GLY n 
1 234 SER n 
1 235 ASN n 
1 236 LEU n 
1 237 ALA n 
1 238 ASP n 
1 239 ALA n 
1 240 ASP n 
1 241 SER n 
1 242 GLY n 
1 243 LEU n 
1 244 GLN n 
1 245 SER n 
1 246 VAL n 
1 247 VAL n 
1 248 ASP n 
1 249 ALA n 
1 250 LEU n 
1 251 GLY n 
1 252 ASN n 
1 253 GLU n 
1 254 GLN n 
1 255 THR n 
1 256 GLU n 
1 257 GLU n 
1 258 THR n 
1 259 ALA n 
1 260 VAL n 
1 261 SER n 
1 262 TYR n 
1 263 THR n 
1 264 TYR n 
1 265 GLN n 
1 266 GLY n 
1 267 LYS n 
1 268 ASP n 
1 269 LYS n 
1 270 VAL n 
1 271 MET n 
1 272 TYR n 
1 273 TYR n 
1 274 LYS n 
1 275 THR n 
1 276 LEU n 
1 277 GLU n 
1 278 ASN n 
1 279 GLY n 
1 280 MET n 
1 281 LYS n 
1 282 PHE n 
1 283 VAL n 
1 284 LEU n 
1 285 THR n 
1 286 ALA n 
1 287 PRO n 
1 288 LYS n 
1 289 THR n 
1 290 GLU n 
1 291 LEU n 
1 292 GLN n 
1 293 GLU n 
1 294 LYS n 
1 295 SER n 
1 296 ARG n 
1 297 GLN n 
1 298 LEU n 
1 299 ALA n 
1 300 LYS n 
1 301 GLN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   301 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'mcpC_1, RIL182_00127, ROSINTL182_06964' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Roseburia intestinalis L1-82' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     536231 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               'T7 Express' 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ACT non-polymer         . 'ACETATE ION'   ?                 'C2 H3 O2 -1'    59.044  
ALA 'L-peptide linking' y ALANINE         ?                 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ?                 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ?                 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ?                 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ?                 'C3 H7 N O2 S'   121.158 
EDO non-polymer         . 1,2-ETHANEDIOL  'ETHYLENE GLYCOL' 'C2 H6 O2'       62.068  
GLN 'L-peptide linking' y GLUTAMINE       ?                 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ?                 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ?                 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ?                 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ?                 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ?                 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ?                 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ?                 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ?                 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ?                 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ?                 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ?                 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ?                 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ?                 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ?                 'C9 H11 N O3'    181.189 
URA non-polymer         . URACIL          ?                 'C4 H4 N2 O2'    112.087 
VAL 'L-peptide linking' y VALINE          ?                 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   12  ?   ?   ?   A . n 
A 1 2   GLY 2   13  ?   ?   ?   A . n 
A 1 3   SER 3   14  ?   ?   ?   A . n 
A 1 4   SER 4   15  ?   ?   ?   A . n 
A 1 5   HIS 5   16  ?   ?   ?   A . n 
A 1 6   HIS 6   17  ?   ?   ?   A . n 
A 1 7   HIS 7   18  18  HIS HIS A . n 
A 1 8   HIS 8   19  19  HIS HIS A . n 
A 1 9   HIS 9   20  20  HIS HIS A . n 
A 1 10  HIS 10  21  21  HIS HIS A . n 
A 1 11  SER 11  22  22  SER SER A . n 
A 1 12  SER 12  23  23  SER SER A . n 
A 1 13  GLY 13  24  24  GLY GLY A . n 
A 1 14  LEU 14  25  25  LEU LEU A . n 
A 1 15  VAL 15  26  26  VAL VAL A . n 
A 1 16  PRO 16  27  27  PRO PRO A . n 
A 1 17  ARG 17  28  28  ARG ARG A . n 
A 1 18  GLY 18  29  29  GLY GLY A . n 
A 1 19  SER 19  30  30  SER SER A . n 
A 1 20  HIS 20  31  ?   ?   ?   A . n 
A 1 21  MET 21  32  ?   ?   ?   A . n 
A 1 22  SER 22  33  ?   ?   ?   A . n 
A 1 23  THR 23  34  ?   ?   ?   A . n 
A 1 24  SER 24  35  35  SER SER A . n 
A 1 25  TYR 25  36  36  TYR TYR A . n 
A 1 26  GLU 26  37  37  GLU GLU A . n 
A 1 27  ASP 27  38  38  ASP ASP A . n 
A 1 28  SER 28  39  39  SER SER A . n 
A 1 29  GLN 29  40  40  GLN GLN A . n 
A 1 30  GLN 30  41  41  GLN GLN A . n 
A 1 31  GLU 31  42  42  GLU GLU A . n 
A 1 32  MET 32  43  43  MET MET A . n 
A 1 33  GLN 33  44  44  GLN GLN A . n 
A 1 34  LEU 34  45  45  LEU LEU A . n 
A 1 35  LYS 35  46  46  LYS LYS A . n 
A 1 36  CYS 36  47  47  CYS CYS A . n 
A 1 37  VAL 37  48  48  VAL VAL A . n 
A 1 38  SER 38  49  49  SER SER A . n 
A 1 39  GLN 39  50  50  GLN GLN A . n 
A 1 40  SER 40  51  51  SER SER A . n 
A 1 41  ASP 41  52  52  ASP ASP A . n 
A 1 42  GLU 42  53  53  GLU GLU A . n 
A 1 43  LEU 43  54  54  LEU LEU A . n 
A 1 44  ASP 44  55  55  ASP ASP A . n 
A 1 45  THR 45  56  56  THR THR A . n 
A 1 46  MET 46  57  57  MET MET A . n 
A 1 47  MET 47  58  58  MET MET A . n 
A 1 48  GLN 48  59  59  GLN GLN A . n 
A 1 49  ASN 49  60  60  ASN ASN A . n 
A 1 50  VAL 50  61  61  VAL VAL A . n 
A 1 51  SER 51  62  62  SER SER A . n 
A 1 52  GLN 52  63  63  GLN GLN A . n 
A 1 53  SER 53  64  64  SER SER A . n 
A 1 54  VAL 54  65  65  VAL VAL A . n 
A 1 55  GLU 55  66  66  GLU GLU A . n 
A 1 56  MET 56  67  67  MET MET A . n 
A 1 57  VAL 57  68  68  VAL VAL A . n 
A 1 58  TYR 58  69  69  TYR TYR A . n 
A 1 59  SER 59  70  70  SER SER A . n 
A 1 60  ILE 60  71  71  ILE ILE A . n 
A 1 61  ALA 61  72  72  ALA ALA A . n 
A 1 62  VAL 62  73  73  VAL VAL A . n 
A 1 63  ALA 63  74  74  ALA ALA A . n 
A 1 64  LYS 64  75  75  LYS LYS A . n 
A 1 65  LEU 65  76  76  LEU LEU A . n 
A 1 66  GLU 66  77  77  GLU GLU A . n 
A 1 67  HIS 67  78  78  HIS HIS A . n 
A 1 68  ALA 68  79  79  ALA ALA A . n 
A 1 69  ALA 69  80  80  ALA ALA A . n 
A 1 70  SER 70  81  81  SER SER A . n 
A 1 71  PHE 71  82  82  PHE PHE A . n 
A 1 72  ARG 72  83  83  ARG ARG A . n 
A 1 73  THR 73  84  84  THR THR A . n 
A 1 74  SER 74  85  85  SER SER A . n 
A 1 75  LYS 75  86  86  LYS LYS A . n 
A 1 76  ASP 76  87  87  ASP ASP A . n 
A 1 77  TYR 77  88  88  TYR TYR A . n 
A 1 78  VAL 78  89  89  VAL VAL A . n 
A 1 79  ASP 79  90  90  ASP ASP A . n 
A 1 80  THR 80  91  91  THR THR A . n 
A 1 81  TYR 81  92  92  TYR TYR A . n 
A 1 82  THR 82  93  93  THR THR A . n 
A 1 83  LYS 83  94  94  LYS LYS A . n 
A 1 84  GLN 84  95  95  GLN GLN A . n 
A 1 85  MET 85  96  96  MET MET A . n 
A 1 86  LEU 86  97  97  LEU LEU A . n 
A 1 87  PRO 87  98  98  PRO PRO A . n 
A 1 88  ILE 88  99  99  ILE ILE A . n 
A 1 89  LEU 89  100 100 LEU LEU A . n 
A 1 90  MET 90  101 101 MET MET A . n 
A 1 91  GLN 91  102 102 GLN GLN A . n 
A 1 92  SER 92  103 103 SER SER A . n 
A 1 93  ALA 93  104 104 ALA ALA A . n 
A 1 94  GLN 94  105 105 GLN GLN A . n 
A 1 95  ASN 95  106 106 ASN ASN A . n 
A 1 96  THR 96  107 107 THR THR A . n 
A 1 97  LYS 97  108 108 LYS LYS A . n 
A 1 98  GLY 98  109 109 GLY GLY A . n 
A 1 99  ALA 99  110 110 ALA ALA A . n 
A 1 100 LEU 100 111 111 LEU LEU A . n 
A 1 101 THR 101 112 112 THR THR A . n 
A 1 102 ALA 102 113 113 ALA ALA A . n 
A 1 103 TYR 103 114 114 TYR TYR A . n 
A 1 104 ILE 104 115 115 ILE ILE A . n 
A 1 105 ARG 105 116 116 ARG ARG A . n 
A 1 106 TYR 106 117 117 TYR TYR A . n 
A 1 107 ASN 107 118 118 ASN ASN A . n 
A 1 108 PRO 108 119 119 PRO PRO A . n 
A 1 109 GLU 109 120 120 GLU GLU A . n 
A 1 110 PHE 110 121 121 PHE PHE A . n 
A 1 111 THR 111 122 122 THR THR A . n 
A 1 112 GLU 112 123 123 GLU GLU A . n 
A 1 113 PRO 113 124 124 PRO PRO A . n 
A 1 114 THR 114 125 125 THR THR A . n 
A 1 115 SER 115 126 126 SER SER A . n 
A 1 116 GLY 116 127 127 GLY GLY A . n 
A 1 117 LEU 117 128 128 LEU LEU A . n 
A 1 118 PHE 118 129 129 PHE PHE A . n 
A 1 119 LEU 119 130 130 LEU LEU A . n 
A 1 120 THR 120 131 131 THR THR A . n 
A 1 121 ARG 121 132 132 ARG ARG A . n 
A 1 122 ASP 122 133 133 ASP ASP A . n 
A 1 123 ASN 123 134 134 ASN ASN A . n 
A 1 124 SER 124 135 135 SER SER A . n 
A 1 125 ASP 125 136 136 ASP ASP A . n 
A 1 126 SER 126 137 137 SER SER A . n 
A 1 127 GLU 127 138 138 GLU GLU A . n 
A 1 128 PHE 128 139 139 PHE PHE A . n 
A 1 129 GLU 129 140 140 GLU GLU A . n 
A 1 130 SER 130 141 141 SER SER A . n 
A 1 131 VAL 131 142 142 VAL VAL A . n 
A 1 132 THR 132 143 143 THR THR A . n 
A 1 133 PRO 133 144 144 PRO PRO A . n 
A 1 134 THR 134 145 145 THR THR A . n 
A 1 135 ASP 135 146 146 ASP ASP A . n 
A 1 136 PHE 136 147 147 PHE PHE A . n 
A 1 137 SER 137 148 148 SER SER A . n 
A 1 138 MET 138 149 149 MET MET A . n 
A 1 139 TYR 139 150 150 TYR TYR A . n 
A 1 140 ASP 140 151 151 ASP ASP A . n 
A 1 141 PRO 141 152 152 PRO PRO A . n 
A 1 142 SER 142 153 153 SER SER A . n 
A 1 143 ASP 143 154 154 ASP ASP A . n 
A 1 144 VAL 144 155 155 VAL VAL A . n 
A 1 145 GLU 145 156 156 GLU GLU A . n 
A 1 146 HIS 146 157 157 HIS HIS A . n 
A 1 147 VAL 147 158 158 VAL VAL A . n 
A 1 148 GLY 148 159 159 GLY GLY A . n 
A 1 149 TRP 149 160 160 TRP TRP A . n 
A 1 150 TYR 150 161 161 TYR TYR A . n 
A 1 151 TYR 151 162 162 TYR TYR A . n 
A 1 152 ILE 152 163 163 ILE ILE A . n 
A 1 153 PRO 153 164 164 PRO PRO A . n 
A 1 154 VAL 154 165 165 VAL VAL A . n 
A 1 155 GLN 155 166 166 GLN GLN A . n 
A 1 156 ASN 156 167 167 ASN ASN A . n 
A 1 157 GLY 157 168 168 GLY GLY A . n 
A 1 158 LYS 158 169 169 LYS LYS A . n 
A 1 159 GLU 159 170 170 GLU GLU A . n 
A 1 160 THR 160 171 171 THR THR A . n 
A 1 161 TRP 161 172 172 TRP TRP A . n 
A 1 162 MET 162 173 173 MET MET A . n 
A 1 163 GLU 163 174 174 GLU GLU A . n 
A 1 164 PRO 164 175 175 PRO PRO A . n 
A 1 165 TYR 165 176 176 TYR TYR A . n 
A 1 166 LEU 166 177 177 LEU LEU A . n 
A 1 167 ASN 167 178 178 ASN ASN A . n 
A 1 168 SER 168 179 179 SER SER A . n 
A 1 169 ASN 169 180 180 ASN ASN A . n 
A 1 170 ILE 170 181 181 ILE ILE A . n 
A 1 171 GLY 171 182 182 GLY GLY A . n 
A 1 172 VAL 172 183 183 VAL VAL A . n 
A 1 173 TYR 173 184 184 TYR TYR A . n 
A 1 174 MET 174 185 185 MET MET A . n 
A 1 175 ILE 175 186 186 ILE ILE A . n 
A 1 176 SER 176 187 187 SER SER A . n 
A 1 177 TYR 177 188 188 TYR TYR A . n 
A 1 178 VAL 178 189 189 VAL VAL A . n 
A 1 179 ILE 179 190 190 ILE ILE A . n 
A 1 180 PRO 180 191 191 PRO PRO A . n 
A 1 181 ILE 181 192 192 ILE ILE A . n 
A 1 182 GLU 182 193 193 GLU GLU A . n 
A 1 183 VAL 183 194 194 VAL VAL A . n 
A 1 184 ASP 184 195 195 ASP ASP A . n 
A 1 185 GLY 185 196 196 GLY GLY A . n 
A 1 186 GLU 186 197 197 GLU GLU A . n 
A 1 187 SER 187 198 198 SER SER A . n 
A 1 188 ILE 188 199 199 ILE ILE A . n 
A 1 189 GLY 189 200 200 GLY GLY A . n 
A 1 190 ILE 190 201 201 ILE ILE A . n 
A 1 191 ILE 191 202 202 ILE ILE A . n 
A 1 192 GLY 192 203 203 GLY GLY A . n 
A 1 193 MET 193 204 204 MET MET A . n 
A 1 194 ASP 194 205 205 ASP ASP A . n 
A 1 195 ILE 195 206 206 ILE ILE A . n 
A 1 196 ASP 196 207 207 ASP ASP A . n 
A 1 197 PHE 197 208 208 PHE PHE A . n 
A 1 198 SER 198 209 209 SER SER A . n 
A 1 199 GLU 199 210 210 GLU GLU A . n 
A 1 200 PHE 200 211 211 PHE PHE A . n 
A 1 201 THR 201 212 212 THR THR A . n 
A 1 202 ASP 202 213 213 ASP ASP A . n 
A 1 203 THR 203 214 214 THR THR A . n 
A 1 204 ILE 204 215 215 ILE ILE A . n 
A 1 205 ASP 205 216 216 ASP ASP A . n 
A 1 206 SER 206 217 217 SER SER A . n 
A 1 207 LEU 207 218 218 LEU LEU A . n 
A 1 208 SER 208 219 219 SER SER A . n 
A 1 209 ILE 209 220 220 ILE ILE A . n 
A 1 210 PHE 210 221 221 PHE PHE A . n 
A 1 211 ASP 211 222 222 ASP ASP A . n 
A 1 212 SER 212 223 223 SER SER A . n 
A 1 213 GLY 213 224 224 GLY GLY A . n 
A 1 214 TYR 214 225 225 TYR TYR A . n 
A 1 215 GLY 215 226 226 GLY GLY A . n 
A 1 216 PHE 216 227 227 PHE PHE A . n 
A 1 217 LEU 217 228 228 LEU LEU A . n 
A 1 218 VAL 218 229 229 VAL VAL A . n 
A 1 219 ASN 219 230 230 ASN ASN A . n 
A 1 220 GLU 220 231 231 GLU GLU A . n 
A 1 221 SER 221 232 232 SER SER A . n 
A 1 222 GLY 222 233 233 GLY GLY A . n 
A 1 223 LYS 223 234 234 LYS LYS A . n 
A 1 224 VAL 224 235 235 VAL VAL A . n 
A 1 225 MET 225 236 236 MET MET A . n 
A 1 226 TYR 226 237 237 TYR TYR A . n 
A 1 227 HIS 227 238 238 HIS HIS A . n 
A 1 228 LYS 228 239 239 LYS LYS A . n 
A 1 229 ASP 229 240 240 ASP ASP A . n 
A 1 230 LEU 230 241 241 LEU LEU A . n 
A 1 231 GLU 231 242 242 GLU GLU A . n 
A 1 232 ILE 232 243 243 ILE ILE A . n 
A 1 233 GLY 233 244 244 GLY GLY A . n 
A 1 234 SER 234 245 245 SER SER A . n 
A 1 235 ASN 235 246 246 ASN ASN A . n 
A 1 236 LEU 236 247 247 LEU LEU A . n 
A 1 237 ALA 237 248 248 ALA ALA A . n 
A 1 238 ASP 238 249 249 ASP ASP A . n 
A 1 239 ALA 239 250 250 ALA ALA A . n 
A 1 240 ASP 240 251 251 ASP ASP A . n 
A 1 241 SER 241 252 252 SER SER A . n 
A 1 242 GLY 242 253 253 GLY GLY A . n 
A 1 243 LEU 243 254 254 LEU LEU A . n 
A 1 244 GLN 244 255 255 GLN GLN A . n 
A 1 245 SER 245 256 256 SER SER A . n 
A 1 246 VAL 246 257 257 VAL VAL A . n 
A 1 247 VAL 247 258 258 VAL VAL A . n 
A 1 248 ASP 248 259 259 ASP ASP A . n 
A 1 249 ALA 249 260 260 ALA ALA A . n 
A 1 250 LEU 250 261 261 LEU LEU A . n 
A 1 251 GLY 251 262 262 GLY GLY A . n 
A 1 252 ASN 252 263 263 ASN ASN A . n 
A 1 253 GLU 253 264 264 GLU GLU A . n 
A 1 254 GLN 254 265 265 GLN GLN A . n 
A 1 255 THR 255 266 266 THR THR A . n 
A 1 256 GLU 256 267 267 GLU GLU A . n 
A 1 257 GLU 257 268 268 GLU GLU A . n 
A 1 258 THR 258 269 269 THR THR A . n 
A 1 259 ALA 259 270 270 ALA ALA A . n 
A 1 260 VAL 260 271 271 VAL VAL A . n 
A 1 261 SER 261 272 272 SER SER A . n 
A 1 262 TYR 262 273 273 TYR TYR A . n 
A 1 263 THR 263 274 274 THR THR A . n 
A 1 264 TYR 264 275 275 TYR TYR A . n 
A 1 265 GLN 265 276 276 GLN GLN A . n 
A 1 266 GLY 266 277 277 GLY GLY A . n 
A 1 267 LYS 267 278 278 LYS LYS A . n 
A 1 268 ASP 268 279 279 ASP ASP A . n 
A 1 269 LYS 269 280 280 LYS LYS A . n 
A 1 270 VAL 270 281 281 VAL VAL A . n 
A 1 271 MET 271 282 282 MET MET A . n 
A 1 272 TYR 272 283 283 TYR TYR A . n 
A 1 273 TYR 273 284 284 TYR TYR A . n 
A 1 274 LYS 274 285 285 LYS LYS A . n 
A 1 275 THR 275 286 286 THR THR A . n 
A 1 276 LEU 276 287 287 LEU LEU A . n 
A 1 277 GLU 277 288 288 GLU GLU A . n 
A 1 278 ASN 278 289 289 ASN ASN A . n 
A 1 279 GLY 279 290 290 GLY GLY A . n 
A 1 280 MET 280 291 291 MET MET A . n 
A 1 281 LYS 281 292 292 LYS LYS A . n 
A 1 282 PHE 282 293 293 PHE PHE A . n 
A 1 283 VAL 283 294 294 VAL VAL A . n 
A 1 284 LEU 284 295 295 LEU LEU A . n 
A 1 285 THR 285 296 296 THR THR A . n 
A 1 286 ALA 286 297 297 ALA ALA A . n 
A 1 287 PRO 287 298 298 PRO PRO A . n 
A 1 288 LYS 288 299 299 LYS LYS A . n 
A 1 289 THR 289 300 300 THR THR A . n 
A 1 290 GLU 290 301 301 GLU GLU A . n 
A 1 291 LEU 291 302 302 LEU LEU A . n 
A 1 292 GLN 292 303 303 GLN GLN A . n 
A 1 293 GLU 293 304 304 GLU GLU A . n 
A 1 294 LYS 294 305 ?   ?   ?   A . n 
A 1 295 SER 295 306 ?   ?   ?   A . n 
A 1 296 ARG 296 307 ?   ?   ?   A . n 
A 1 297 GLN 297 308 ?   ?   ?   A . n 
A 1 298 LEU 298 309 ?   ?   ?   A . n 
A 1 299 ALA 299 310 ?   ?   ?   A . n 
A 1 300 LYS 300 311 ?   ?   ?   A . n 
A 1 301 GLN 301 312 ?   ?   ?   A . n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 ACT ? ? ACT ? ? 'SUBJECT OF INVESTIGATION' ? 
2 URA ? ? URA ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 URA 1   401 401 URA URA A . 
C 3 ACT 1   402 402 ACT ACT A . 
D 4 EDO 1   403 403 EDO EDO A . 
E 5 HOH 1   501 282 HOH HOH A . 
E 5 HOH 2   502 291 HOH HOH A . 
E 5 HOH 3   503 279 HOH HOH A . 
E 5 HOH 4   504 206 HOH HOH A . 
E 5 HOH 5   505 223 HOH HOH A . 
E 5 HOH 6   506 201 HOH HOH A . 
E 5 HOH 7   507 198 HOH HOH A . 
E 5 HOH 8   508 221 HOH HOH A . 
E 5 HOH 9   509 187 HOH HOH A . 
E 5 HOH 10  510 253 HOH HOH A . 
E 5 HOH 11  511 179 HOH HOH A . 
E 5 HOH 12  512 144 HOH HOH A . 
E 5 HOH 13  513 31  HOH HOH A . 
E 5 HOH 14  514 53  HOH HOH A . 
E 5 HOH 15  515 74  HOH HOH A . 
E 5 HOH 16  516 182 HOH HOH A . 
E 5 HOH 17  517 112 HOH HOH A . 
E 5 HOH 18  518 299 HOH HOH A . 
E 5 HOH 19  519 83  HOH HOH A . 
E 5 HOH 20  520 91  HOH HOH A . 
E 5 HOH 21  521 269 HOH HOH A . 
E 5 HOH 22  522 121 HOH HOH A . 
E 5 HOH 23  523 90  HOH HOH A . 
E 5 HOH 24  524 260 HOH HOH A . 
E 5 HOH 25  525 36  HOH HOH A . 
E 5 HOH 26  526 41  HOH HOH A . 
E 5 HOH 27  527 104 HOH HOH A . 
E 5 HOH 28  528 161 HOH HOH A . 
E 5 HOH 29  529 65  HOH HOH A . 
E 5 HOH 30  530 150 HOH HOH A . 
E 5 HOH 31  531 48  HOH HOH A . 
E 5 HOH 32  532 251 HOH HOH A . 
E 5 HOH 33  533 75  HOH HOH A . 
E 5 HOH 34  534 43  HOH HOH A . 
E 5 HOH 35  535 222 HOH HOH A . 
E 5 HOH 36  536 133 HOH HOH A . 
E 5 HOH 37  537 224 HOH HOH A . 
E 5 HOH 38  538 155 HOH HOH A . 
E 5 HOH 39  539 9   HOH HOH A . 
E 5 HOH 40  540 304 HOH HOH A . 
E 5 HOH 41  541 180 HOH HOH A . 
E 5 HOH 42  542 58  HOH HOH A . 
E 5 HOH 43  543 231 HOH HOH A . 
E 5 HOH 44  544 77  HOH HOH A . 
E 5 HOH 45  545 158 HOH HOH A . 
E 5 HOH 46  546 307 HOH HOH A . 
E 5 HOH 47  547 160 HOH HOH A . 
E 5 HOH 48  548 271 HOH HOH A . 
E 5 HOH 49  549 13  HOH HOH A . 
E 5 HOH 50  550 176 HOH HOH A . 
E 5 HOH 51  551 92  HOH HOH A . 
E 5 HOH 52  552 82  HOH HOH A . 
E 5 HOH 53  553 113 HOH HOH A . 
E 5 HOH 54  554 8   HOH HOH A . 
E 5 HOH 55  555 86  HOH HOH A . 
E 5 HOH 56  556 21  HOH HOH A . 
E 5 HOH 57  557 303 HOH HOH A . 
E 5 HOH 58  558 40  HOH HOH A . 
E 5 HOH 59  559 51  HOH HOH A . 
E 5 HOH 60  560 6   HOH HOH A . 
E 5 HOH 61  561 196 HOH HOH A . 
E 5 HOH 62  562 71  HOH HOH A . 
E 5 HOH 63  563 338 HOH HOH A . 
E 5 HOH 64  564 93  HOH HOH A . 
E 5 HOH 65  565 105 HOH HOH A . 
E 5 HOH 66  566 26  HOH HOH A . 
E 5 HOH 67  567 56  HOH HOH A . 
E 5 HOH 68  568 12  HOH HOH A . 
E 5 HOH 69  569 2   HOH HOH A . 
E 5 HOH 70  570 302 HOH HOH A . 
E 5 HOH 71  571 249 HOH HOH A . 
E 5 HOH 72  572 73  HOH HOH A . 
E 5 HOH 73  573 240 HOH HOH A . 
E 5 HOH 74  574 49  HOH HOH A . 
E 5 HOH 75  575 60  HOH HOH A . 
E 5 HOH 76  576 102 HOH HOH A . 
E 5 HOH 77  577 37  HOH HOH A . 
E 5 HOH 78  578 28  HOH HOH A . 
E 5 HOH 79  579 346 HOH HOH A . 
E 5 HOH 80  580 111 HOH HOH A . 
E 5 HOH 81  581 300 HOH HOH A . 
E 5 HOH 82  582 23  HOH HOH A . 
E 5 HOH 83  583 7   HOH HOH A . 
E 5 HOH 84  584 220 HOH HOH A . 
E 5 HOH 85  585 62  HOH HOH A . 
E 5 HOH 86  586 128 HOH HOH A . 
E 5 HOH 87  587 190 HOH HOH A . 
E 5 HOH 88  588 281 HOH HOH A . 
E 5 HOH 89  589 191 HOH HOH A . 
E 5 HOH 90  590 38  HOH HOH A . 
E 5 HOH 91  591 78  HOH HOH A . 
E 5 HOH 92  592 305 HOH HOH A . 
E 5 HOH 93  593 54  HOH HOH A . 
E 5 HOH 94  594 127 HOH HOH A . 
E 5 HOH 95  595 27  HOH HOH A . 
E 5 HOH 96  596 19  HOH HOH A . 
E 5 HOH 97  597 29  HOH HOH A . 
E 5 HOH 98  598 14  HOH HOH A . 
E 5 HOH 99  599 116 HOH HOH A . 
E 5 HOH 100 600 145 HOH HOH A . 
E 5 HOH 101 601 45  HOH HOH A . 
E 5 HOH 102 602 151 HOH HOH A . 
E 5 HOH 103 603 277 HOH HOH A . 
E 5 HOH 104 604 66  HOH HOH A . 
E 5 HOH 105 605 215 HOH HOH A . 
E 5 HOH 106 606 67  HOH HOH A . 
E 5 HOH 107 607 174 HOH HOH A . 
E 5 HOH 108 608 11  HOH HOH A . 
E 5 HOH 109 609 119 HOH HOH A . 
E 5 HOH 110 610 32  HOH HOH A . 
E 5 HOH 111 611 177 HOH HOH A . 
E 5 HOH 112 612 80  HOH HOH A . 
E 5 HOH 113 613 55  HOH HOH A . 
E 5 HOH 114 614 4   HOH HOH A . 
E 5 HOH 115 615 76  HOH HOH A . 
E 5 HOH 116 616 130 HOH HOH A . 
E 5 HOH 117 617 184 HOH HOH A . 
E 5 HOH 118 618 241 HOH HOH A . 
E 5 HOH 119 619 125 HOH HOH A . 
E 5 HOH 120 620 59  HOH HOH A . 
E 5 HOH 121 621 194 HOH HOH A . 
E 5 HOH 122 622 39  HOH HOH A . 
E 5 HOH 123 623 44  HOH HOH A . 
E 5 HOH 124 624 166 HOH HOH A . 
E 5 HOH 125 625 15  HOH HOH A . 
E 5 HOH 126 626 146 HOH HOH A . 
E 5 HOH 127 627 69  HOH HOH A . 
E 5 HOH 128 628 341 HOH HOH A . 
E 5 HOH 129 629 5   HOH HOH A . 
E 5 HOH 130 630 137 HOH HOH A . 
E 5 HOH 131 631 257 HOH HOH A . 
E 5 HOH 132 632 267 HOH HOH A . 
E 5 HOH 133 633 245 HOH HOH A . 
E 5 HOH 134 634 340 HOH HOH A . 
E 5 HOH 135 635 120 HOH HOH A . 
E 5 HOH 136 636 266 HOH HOH A . 
E 5 HOH 137 637 46  HOH HOH A . 
E 5 HOH 138 638 35  HOH HOH A . 
E 5 HOH 139 639 103 HOH HOH A . 
E 5 HOH 140 640 287 HOH HOH A . 
E 5 HOH 141 641 154 HOH HOH A . 
E 5 HOH 142 642 124 HOH HOH A . 
E 5 HOH 143 643 202 HOH HOH A . 
E 5 HOH 144 644 24  HOH HOH A . 
E 5 HOH 145 645 33  HOH HOH A . 
E 5 HOH 146 646 162 HOH HOH A . 
E 5 HOH 147 647 235 HOH HOH A . 
E 5 HOH 148 648 247 HOH HOH A . 
E 5 HOH 149 649 50  HOH HOH A . 
E 5 HOH 150 650 256 HOH HOH A . 
E 5 HOH 151 651 149 HOH HOH A . 
E 5 HOH 152 652 288 HOH HOH A . 
E 5 HOH 153 653 139 HOH HOH A . 
E 5 HOH 154 654 199 HOH HOH A . 
E 5 HOH 155 655 115 HOH HOH A . 
E 5 HOH 156 656 99  HOH HOH A . 
E 5 HOH 157 657 106 HOH HOH A . 
E 5 HOH 158 658 85  HOH HOH A . 
E 5 HOH 159 659 63  HOH HOH A . 
E 5 HOH 160 660 18  HOH HOH A . 
E 5 HOH 161 661 52  HOH HOH A . 
E 5 HOH 162 662 10  HOH HOH A . 
E 5 HOH 163 663 248 HOH HOH A . 
E 5 HOH 164 664 22  HOH HOH A . 
E 5 HOH 165 665 47  HOH HOH A . 
E 5 HOH 166 666 321 HOH HOH A . 
E 5 HOH 167 667 57  HOH HOH A . 
E 5 HOH 168 668 97  HOH HOH A . 
E 5 HOH 169 669 309 HOH HOH A . 
E 5 HOH 170 670 25  HOH HOH A . 
E 5 HOH 171 671 284 HOH HOH A . 
E 5 HOH 172 672 207 HOH HOH A . 
E 5 HOH 173 673 114 HOH HOH A . 
E 5 HOH 174 674 109 HOH HOH A . 
E 5 HOH 175 675 95  HOH HOH A . 
E 5 HOH 176 676 278 HOH HOH A . 
E 5 HOH 177 677 68  HOH HOH A . 
E 5 HOH 178 678 339 HOH HOH A . 
E 5 HOH 179 679 243 HOH HOH A . 
E 5 HOH 180 680 204 HOH HOH A . 
E 5 HOH 181 681 311 HOH HOH A . 
E 5 HOH 182 682 138 HOH HOH A . 
E 5 HOH 183 683 20  HOH HOH A . 
E 5 HOH 184 684 331 HOH HOH A . 
E 5 HOH 185 685 117 HOH HOH A . 
E 5 HOH 186 686 264 HOH HOH A . 
E 5 HOH 187 687 280 HOH HOH A . 
E 5 HOH 188 688 17  HOH HOH A . 
E 5 HOH 189 689 88  HOH HOH A . 
E 5 HOH 190 690 1   HOH HOH A . 
E 5 HOH 191 691 343 HOH HOH A . 
E 5 HOH 192 692 64  HOH HOH A . 
E 5 HOH 193 693 323 HOH HOH A . 
E 5 HOH 194 694 3   HOH HOH A . 
E 5 HOH 195 695 335 HOH HOH A . 
E 5 HOH 196 696 129 HOH HOH A . 
E 5 HOH 197 697 30  HOH HOH A . 
E 5 HOH 198 698 237 HOH HOH A . 
E 5 HOH 199 699 34  HOH HOH A . 
E 5 HOH 200 700 122 HOH HOH A . 
E 5 HOH 201 701 94  HOH HOH A . 
E 5 HOH 202 702 314 HOH HOH A . 
E 5 HOH 203 703 246 HOH HOH A . 
E 5 HOH 204 704 233 HOH HOH A . 
E 5 HOH 205 705 159 HOH HOH A . 
E 5 HOH 206 706 100 HOH HOH A . 
E 5 HOH 207 707 101 HOH HOH A . 
E 5 HOH 208 708 147 HOH HOH A . 
E 5 HOH 209 709 16  HOH HOH A . 
E 5 HOH 210 710 98  HOH HOH A . 
E 5 HOH 211 711 272 HOH HOH A . 
E 5 HOH 212 712 295 HOH HOH A . 
E 5 HOH 213 713 140 HOH HOH A . 
E 5 HOH 214 714 132 HOH HOH A . 
E 5 HOH 215 715 171 HOH HOH A . 
E 5 HOH 216 716 254 HOH HOH A . 
E 5 HOH 217 717 336 HOH HOH A . 
E 5 HOH 218 718 320 HOH HOH A . 
E 5 HOH 219 719 301 HOH HOH A . 
E 5 HOH 220 720 255 HOH HOH A . 
E 5 HOH 221 721 153 HOH HOH A . 
E 5 HOH 222 722 96  HOH HOH A . 
E 5 HOH 223 723 234 HOH HOH A . 
E 5 HOH 224 724 298 HOH HOH A . 
E 5 HOH 225 725 172 HOH HOH A . 
E 5 HOH 226 726 289 HOH HOH A . 
E 5 HOH 227 727 319 HOH HOH A . 
E 5 HOH 228 728 306 HOH HOH A . 
E 5 HOH 229 729 330 HOH HOH A . 
E 5 HOH 230 730 310 HOH HOH A . 
E 5 HOH 231 731 342 HOH HOH A . 
E 5 HOH 232 732 131 HOH HOH A . 
E 5 HOH 233 733 315 HOH HOH A . 
E 5 HOH 234 734 316 HOH HOH A . 
E 5 HOH 235 735 328 HOH HOH A . 
E 5 HOH 236 736 142 HOH HOH A . 
E 5 HOH 237 737 229 HOH HOH A . 
E 5 HOH 238 738 84  HOH HOH A . 
E 5 HOH 239 739 285 HOH HOH A . 
E 5 HOH 240 740 219 HOH HOH A . 
E 5 HOH 241 741 327 HOH HOH A . 
E 5 HOH 242 742 72  HOH HOH A . 
E 5 HOH 243 743 157 HOH HOH A . 
E 5 HOH 244 744 329 HOH HOH A . 
E 5 HOH 245 745 290 HOH HOH A . 
E 5 HOH 246 746 337 HOH HOH A . 
E 5 HOH 247 747 178 HOH HOH A . 
E 5 HOH 248 748 344 HOH HOH A . 
E 5 HOH 249 749 317 HOH HOH A . 
E 5 HOH 250 750 89  HOH HOH A . 
E 5 HOH 251 751 334 HOH HOH A . 
E 5 HOH 252 752 230 HOH HOH A . 
E 5 HOH 253 753 326 HOH HOH A . 
E 5 HOH 254 754 156 HOH HOH A . 
E 5 HOH 255 755 273 HOH HOH A . 
E 5 HOH 256 756 214 HOH HOH A . 
E 5 HOH 257 757 283 HOH HOH A . 
E 5 HOH 258 758 324 HOH HOH A . 
E 5 HOH 259 759 193 HOH HOH A . 
E 5 HOH 260 760 333 HOH HOH A . 
E 5 HOH 261 761 211 HOH HOH A . 
E 5 HOH 262 762 332 HOH HOH A . 
E 5 HOH 263 763 228 HOH HOH A . 
E 5 HOH 264 764 312 HOH HOH A . 
E 5 HOH 265 765 322 HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.20.1-4487 1 
? 'model building' ? ? ? ? ? ? ? ? ? ? ? Coot   ? ? ? .           2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           3 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XSCALE ? ? ? .           4 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? .           5 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   92.190 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9HVJ 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     35.000 
_cell.length_a_esd                 ? 
_cell.length_b                     93.080 
_cell.length_b_esd                 ? 
_cell.length_c                     44.380 
_cell.length_c_esd                 ? 
_cell.volume                       144475.562 
_cell.volume_esd                   ? 
_cell.Z_PDB                        2 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9HVJ 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                4 
_symmetry.space_group_name_Hall            'P 2yb' 
_symmetry.space_group_name_H-M             'P 1 21 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9HVJ 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.13 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          42.35 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.2 M Potassium fluoride, 20% (w/v) PEG 3350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 9M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2024-10-02 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.87313 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'ESRF BEAMLINE ID23-2' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.87313 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ID23-2 
_diffrn_source.pdbx_synchrotron_site       ESRF 
# 
_reflns.B_iso_Wilson_estimate                          10.32 
_reflns.entry_id                                       9HVJ 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.46 
_reflns.d_resolution_low                               46.54 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     48349 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.07 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                6.8 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          13.29 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                0.06886 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.996 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.1673 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.464 
_reflns_shell.d_res_low                                     1.516 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           3.31 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             4659 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               6.6 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               0.3939 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.732 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          95.55 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.9419 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               15.83 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9HVJ 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.46 
_refine.ls_d_res_low                             46.54 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     48332 
_refine.ls_number_reflns_R_free                  2416 
_refine.ls_number_reflns_R_work                  45916 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.07 
_refine.ls_percent_reflns_R_free                 5.00 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1691 
_refine.ls_R_factor_R_free                       0.1889 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1681 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.37 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 18.8534 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.1544 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.46 
_refine_hist.d_res_low                        46.54 
_refine_hist.number_atoms_solvent             265 
_refine_hist.number_atoms_total               2512 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2231 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         16 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0068 ? 2376 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.8948 ? 3243 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0856 ? 360  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0066 ? 422  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 5.3267 ? 337  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.46 1.49  . . 132 2507 92.79 . . . . 0.2366 . . . . . . . . . . . 0.3011 
'X-RAY DIFFRACTION' 1.49 1.53  . . 143 2726 99.34 . . . . 0.2268 . . . . . . . . . . . 0.2401 
'X-RAY DIFFRACTION' 1.53 1.56  . . 141 2678 99.30 . . . . 0.2176 . . . . . . . . . . . 0.2427 
'X-RAY DIFFRACTION' 1.56 1.60  . . 143 2709 99.58 . . . . 0.2117 . . . . . . . . . . . 0.2594 
'X-RAY DIFFRACTION' 1.60 1.64  . . 142 2711 99.51 . . . . 0.1914 . . . . . . . . . . . 0.2373 
'X-RAY DIFFRACTION' 1.64 1.69  . . 143 2715 99.62 . . . . 0.1831 . . . . . . . . . . . 0.2060 
'X-RAY DIFFRACTION' 1.69 1.75  . . 143 2711 99.51 . . . . 0.1772 . . . . . . . . . . . 0.2082 
'X-RAY DIFFRACTION' 1.75 1.81  . . 142 2687 99.61 . . . . 0.1690 . . . . . . . . . . . 0.1948 
'X-RAY DIFFRACTION' 1.81 1.88  . . 141 2694 99.61 . . . . 0.1726 . . . . . . . . . . . 0.2091 
'X-RAY DIFFRACTION' 1.88 1.97  . . 144 2726 99.62 . . . . 0.1684 . . . . . . . . . . . 0.2050 
'X-RAY DIFFRACTION' 1.97 2.07  . . 143 2717 99.58 . . . . 0.1656 . . . . . . . . . . . 0.2031 
'X-RAY DIFFRACTION' 2.07 2.20  . . 143 2728 99.48 . . . . 0.1565 . . . . . . . . . . . 0.1820 
'X-RAY DIFFRACTION' 2.20 2.37  . . 142 2696 99.51 . . . . 0.1616 . . . . . . . . . . . 0.1688 
'X-RAY DIFFRACTION' 2.37 2.61  . . 143 2721 99.34 . . . . 0.1648 . . . . . . . . . . . 0.1866 
'X-RAY DIFFRACTION' 2.61 2.99  . . 143 2709 99.48 . . . . 0.1699 . . . . . . . . . . . 0.1795 
'X-RAY DIFFRACTION' 2.99 3.76  . . 144 2726 99.51 . . . . 0.1505 . . . . . . . . . . . 0.1592 
'X-RAY DIFFRACTION' 3.76 46.54 . . 144 2755 98.84 . . . . 0.1441 . . . . . . . . . . . 0.1504 
# 
_struct.entry_id                     9HVJ 
_struct.title                        
'Ligand binding domain of Roseburia intestinalis L1-82 uracil chemoreceptor (dCache) in complex with uracil and acetate' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9HVJ 
_struct_keywords.text            'Chemoreceptor, dCache domain, Uracil, Acetate, Chemotaxis, SIGNALING PROTEIN' 
_struct_keywords.pdbx_keywords   'SIGNALING PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 5 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    C7GAN4_9FIRM 
_struct_ref.pdbx_db_accession          C7GAN4 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;STSYEDSQQEMQLKCVSQSDELDTMMQNVSQSVEMVYSIAVAKLEHAASFRTSKDYVDTYTKQMLPILMQSAQNTKGALT
AYIRYNPEFTEPTSGLFLTRDNSDSEFESVTPTDFSMYDPSDVEHVGWYYIPVQNGKETWMEPYLNSNIGVYMISYVIPI
EVDGESIGIIGMDIDFSEFTDTIDSLSIFDSGYGFLVNESGKVMYHKDLEIGSNLADADSGLQSVVDALGNEQTEETAVS
YTYQGKDKVMYYKTLENGMKFVLTAPKTELQEKSRQLAKQ
;
_struct_ref.pdbx_align_begin           33 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9HVJ 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 22 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 301 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             C7GAN4 
_struct_ref_seq.db_align_beg                  33 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  312 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       33 
_struct_ref_seq.pdbx_auth_seq_align_end       312 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9HVJ MET A 1  ? UNP C7GAN4 ? ? 'initiating methionine' 12 1  
1 9HVJ GLY A 2  ? UNP C7GAN4 ? ? 'expression tag'        13 2  
1 9HVJ SER A 3  ? UNP C7GAN4 ? ? 'expression tag'        14 3  
1 9HVJ SER A 4  ? UNP C7GAN4 ? ? 'expression tag'        15 4  
1 9HVJ HIS A 5  ? UNP C7GAN4 ? ? 'expression tag'        16 5  
1 9HVJ HIS A 6  ? UNP C7GAN4 ? ? 'expression tag'        17 6  
1 9HVJ HIS A 7  ? UNP C7GAN4 ? ? 'expression tag'        18 7  
1 9HVJ HIS A 8  ? UNP C7GAN4 ? ? 'expression tag'        19 8  
1 9HVJ HIS A 9  ? UNP C7GAN4 ? ? 'expression tag'        20 9  
1 9HVJ HIS A 10 ? UNP C7GAN4 ? ? 'expression tag'        21 10 
1 9HVJ SER A 11 ? UNP C7GAN4 ? ? 'expression tag'        22 11 
1 9HVJ SER A 12 ? UNP C7GAN4 ? ? 'expression tag'        23 12 
1 9HVJ GLY A 13 ? UNP C7GAN4 ? ? 'expression tag'        24 13 
1 9HVJ LEU A 14 ? UNP C7GAN4 ? ? 'expression tag'        25 14 
1 9HVJ VAL A 15 ? UNP C7GAN4 ? ? 'expression tag'        26 15 
1 9HVJ PRO A 16 ? UNP C7GAN4 ? ? 'expression tag'        27 16 
1 9HVJ ARG A 17 ? UNP C7GAN4 ? ? 'expression tag'        28 17 
1 9HVJ GLY A 18 ? UNP C7GAN4 ? ? 'expression tag'        29 18 
1 9HVJ SER A 19 ? UNP C7GAN4 ? ? 'expression tag'        30 19 
1 9HVJ HIS A 20 ? UNP C7GAN4 ? ? 'expression tag'        31 20 
1 9HVJ MET A 21 ? UNP C7GAN4 ? ? 'expression tag'        32 21 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 710   ? 
1 MORE         4     ? 
1 'SSA (A^2)'  14170 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 TYR A 25  ? LEU A 65  ? TYR A 36  LEU A 76  1 ? 41 
HELX_P HELX_P2  AA2 HIS A 67  ? ARG A 72  ? HIS A 78  ARG A 83  5 ? 6  
HELX_P HELX_P3  AA3 SER A 74  ? ASN A 95  ? SER A 85  ASN A 106 1 ? 22 
HELX_P HELX_P4  AA4 ASP A 135 ? TYR A 139 ? ASP A 146 TYR A 150 5 ? 5  
HELX_P HELX_P5  AA5 ASP A 143 ? GLY A 157 ? ASP A 154 GLY A 168 1 ? 15 
HELX_P HELX_P6  AA6 PHE A 197 ? SER A 206 ? PHE A 208 SER A 217 1 ? 10 
HELX_P HELX_P7  AA7 ASN A 235 ? ALA A 239 ? ASN A 246 ALA A 250 5 ? 5  
HELX_P HELX_P8  AA8 ASP A 240 ? GLY A 242 ? ASP A 251 GLY A 253 5 ? 3  
HELX_P HELX_P9  AA9 LEU A 243 ? GLY A 251 ? LEU A 254 GLY A 262 1 ? 9  
HELX_P HELX_P10 AB1 ASN A 252 ? GLU A 256 ? ASN A 263 GLU A 267 5 ? 5  
HELX_P HELX_P11 AB2 LYS A 288 ? GLN A 292 ? LYS A 299 GLN A 303 1 ? 5  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 6 ? 
AA2 ? 5 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 GLU A 129 ? VAL A 131 ? GLU A 140 VAL A 142 
AA1 2 LEU A 117 ? THR A 120 ? LEU A 128 THR A 131 
AA1 3 THR A 101 ? TYR A 106 ? THR A 112 TYR A 117 
AA1 4 GLU A 186 ? ASP A 196 ? GLU A 197 ASP A 207 
AA1 5 VAL A 172 ? VAL A 183 ? VAL A 183 VAL A 194 
AA1 6 THR A 160 ? ASN A 167 ? THR A 171 ASN A 178 
AA2 1 VAL A 224 ? TYR A 226 ? VAL A 235 TYR A 237 
AA2 2 TYR A 214 ? VAL A 218 ? TYR A 225 VAL A 229 
AA2 3 LYS A 281 ? PRO A 287 ? LYS A 292 PRO A 298 
AA2 4 LYS A 267 ? THR A 275 ? LYS A 278 THR A 286 
AA2 5 VAL A 260 ? TYR A 264 ? VAL A 271 TYR A 275 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O VAL A 131 ? O VAL A 142 N PHE A 118 ? N PHE A 129 
AA1 2 3 O LEU A 119 ? O LEU A 130 N ALA A 102 ? N ALA A 113 
AA1 3 4 N ARG A 105 ? N ARG A 116 O ILE A 190 ? O ILE A 201 
AA1 4 5 O GLY A 189 ? O GLY A 200 N ILE A 181 ? N ILE A 192 
AA1 5 6 O SER A 176 ? O SER A 187 N MET A 162 ? N MET A 173 
AA2 1 2 O TYR A 226 ? O TYR A 237 N LEU A 217 ? N LEU A 228 
AA2 2 3 N VAL A 218 ? N VAL A 229 O LYS A 281 ? O LYS A 292 
AA2 3 4 O LEU A 284 ? O LEU A 295 N TYR A 272 ? N TYR A 283 
AA2 4 5 O LYS A 269 ? O LYS A 280 N TYR A 262 ? N TYR A 273 
# 
_pdbx_entry_details.entry_id                   9HVJ 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 PHE A 221 ? ? 57.65   -141.24 
2 1 SER A 223 ? ? -145.26 16.70   
3 1 ASP A 251 ? ? -170.63 126.34  
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z       
2 -x,y+1/2,-z 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 12  ? A MET 1   
2  1 Y 1 A GLY 13  ? A GLY 2   
3  1 Y 1 A SER 14  ? A SER 3   
4  1 Y 1 A SER 15  ? A SER 4   
5  1 Y 1 A HIS 16  ? A HIS 5   
6  1 Y 1 A HIS 17  ? A HIS 6   
7  1 Y 1 A HIS 31  ? A HIS 20  
8  1 Y 1 A MET 32  ? A MET 21  
9  1 Y 1 A SER 33  ? A SER 22  
10 1 Y 1 A THR 34  ? A THR 23  
11 1 Y 1 A LYS 305 ? A LYS 294 
12 1 Y 1 A SER 306 ? A SER 295 
13 1 Y 1 A ARG 307 ? A ARG 296 
14 1 Y 1 A GLN 308 ? A GLN 297 
15 1 Y 1 A LEU 309 ? A LEU 298 
16 1 Y 1 A ALA 310 ? A ALA 299 
17 1 Y 1 A LYS 311 ? A LYS 300 
18 1 Y 1 A GLN 312 ? A GLN 301 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ACT C    C N N 1   
ACT O    O N N 2   
ACT OXT  O N N 3   
ACT CH3  C N N 4   
ACT H1   H N N 5   
ACT H2   H N N 6   
ACT H3   H N N 7   
ALA N    N N N 8   
ALA CA   C N S 9   
ALA C    C N N 10  
ALA O    O N N 11  
ALA CB   C N N 12  
ALA OXT  O N N 13  
ALA H    H N N 14  
ALA H2   H N N 15  
ALA HA   H N N 16  
ALA HB1  H N N 17  
ALA HB2  H N N 18  
ALA HB3  H N N 19  
ALA HXT  H N N 20  
ARG N    N N N 21  
ARG CA   C N S 22  
ARG C    C N N 23  
ARG O    O N N 24  
ARG CB   C N N 25  
ARG CG   C N N 26  
ARG CD   C N N 27  
ARG NE   N N N 28  
ARG CZ   C N N 29  
ARG NH1  N N N 30  
ARG NH2  N N N 31  
ARG OXT  O N N 32  
ARG H    H N N 33  
ARG H2   H N N 34  
ARG HA   H N N 35  
ARG HB2  H N N 36  
ARG HB3  H N N 37  
ARG HG2  H N N 38  
ARG HG3  H N N 39  
ARG HD2  H N N 40  
ARG HD3  H N N 41  
ARG HE   H N N 42  
ARG HH11 H N N 43  
ARG HH12 H N N 44  
ARG HH21 H N N 45  
ARG HH22 H N N 46  
ARG HXT  H N N 47  
ASN N    N N N 48  
ASN CA   C N S 49  
ASN C    C N N 50  
ASN O    O N N 51  
ASN CB   C N N 52  
ASN CG   C N N 53  
ASN OD1  O N N 54  
ASN ND2  N N N 55  
ASN OXT  O N N 56  
ASN H    H N N 57  
ASN H2   H N N 58  
ASN HA   H N N 59  
ASN HB2  H N N 60  
ASN HB3  H N N 61  
ASN HD21 H N N 62  
ASN HD22 H N N 63  
ASN HXT  H N N 64  
ASP N    N N N 65  
ASP CA   C N S 66  
ASP C    C N N 67  
ASP O    O N N 68  
ASP CB   C N N 69  
ASP CG   C N N 70  
ASP OD1  O N N 71  
ASP OD2  O N N 72  
ASP OXT  O N N 73  
ASP H    H N N 74  
ASP H2   H N N 75  
ASP HA   H N N 76  
ASP HB2  H N N 77  
ASP HB3  H N N 78  
ASP HD2  H N N 79  
ASP HXT  H N N 80  
CYS N    N N N 81  
CYS CA   C N R 82  
CYS C    C N N 83  
CYS O    O N N 84  
CYS CB   C N N 85  
CYS SG   S N N 86  
CYS OXT  O N N 87  
CYS H    H N N 88  
CYS H2   H N N 89  
CYS HA   H N N 90  
CYS HB2  H N N 91  
CYS HB3  H N N 92  
CYS HG   H N N 93  
CYS HXT  H N N 94  
EDO C1   C N N 95  
EDO O1   O N N 96  
EDO C2   C N N 97  
EDO O2   O N N 98  
EDO H11  H N N 99  
EDO H12  H N N 100 
EDO HO1  H N N 101 
EDO H21  H N N 102 
EDO H22  H N N 103 
EDO HO2  H N N 104 
GLN N    N N N 105 
GLN CA   C N S 106 
GLN C    C N N 107 
GLN O    O N N 108 
GLN CB   C N N 109 
GLN CG   C N N 110 
GLN CD   C N N 111 
GLN OE1  O N N 112 
GLN NE2  N N N 113 
GLN OXT  O N N 114 
GLN H    H N N 115 
GLN H2   H N N 116 
GLN HA   H N N 117 
GLN HB2  H N N 118 
GLN HB3  H N N 119 
GLN HG2  H N N 120 
GLN HG3  H N N 121 
GLN HE21 H N N 122 
GLN HE22 H N N 123 
GLN HXT  H N N 124 
GLU N    N N N 125 
GLU CA   C N S 126 
GLU C    C N N 127 
GLU O    O N N 128 
GLU CB   C N N 129 
GLU CG   C N N 130 
GLU CD   C N N 131 
GLU OE1  O N N 132 
GLU OE2  O N N 133 
GLU OXT  O N N 134 
GLU H    H N N 135 
GLU H2   H N N 136 
GLU HA   H N N 137 
GLU HB2  H N N 138 
GLU HB3  H N N 139 
GLU HG2  H N N 140 
GLU HG3  H N N 141 
GLU HE2  H N N 142 
GLU HXT  H N N 143 
GLY N    N N N 144 
GLY CA   C N N 145 
GLY C    C N N 146 
GLY O    O N N 147 
GLY OXT  O N N 148 
GLY H    H N N 149 
GLY H2   H N N 150 
GLY HA2  H N N 151 
GLY HA3  H N N 152 
GLY HXT  H N N 153 
HIS N    N N N 154 
HIS CA   C N S 155 
HIS C    C N N 156 
HIS O    O N N 157 
HIS CB   C N N 158 
HIS CG   C Y N 159 
HIS ND1  N Y N 160 
HIS CD2  C Y N 161 
HIS CE1  C Y N 162 
HIS NE2  N Y N 163 
HIS OXT  O N N 164 
HIS H    H N N 165 
HIS H2   H N N 166 
HIS HA   H N N 167 
HIS HB2  H N N 168 
HIS HB3  H N N 169 
HIS HD1  H N N 170 
HIS HD2  H N N 171 
HIS HE1  H N N 172 
HIS HE2  H N N 173 
HIS HXT  H N N 174 
HOH O    O N N 175 
HOH H1   H N N 176 
HOH H2   H N N 177 
ILE N    N N N 178 
ILE CA   C N S 179 
ILE C    C N N 180 
ILE O    O N N 181 
ILE CB   C N S 182 
ILE CG1  C N N 183 
ILE CG2  C N N 184 
ILE CD1  C N N 185 
ILE OXT  O N N 186 
ILE H    H N N 187 
ILE H2   H N N 188 
ILE HA   H N N 189 
ILE HB   H N N 190 
ILE HG12 H N N 191 
ILE HG13 H N N 192 
ILE HG21 H N N 193 
ILE HG22 H N N 194 
ILE HG23 H N N 195 
ILE HD11 H N N 196 
ILE HD12 H N N 197 
ILE HD13 H N N 198 
ILE HXT  H N N 199 
LEU N    N N N 200 
LEU CA   C N S 201 
LEU C    C N N 202 
LEU O    O N N 203 
LEU CB   C N N 204 
LEU CG   C N N 205 
LEU CD1  C N N 206 
LEU CD2  C N N 207 
LEU OXT  O N N 208 
LEU H    H N N 209 
LEU H2   H N N 210 
LEU HA   H N N 211 
LEU HB2  H N N 212 
LEU HB3  H N N 213 
LEU HG   H N N 214 
LEU HD11 H N N 215 
LEU HD12 H N N 216 
LEU HD13 H N N 217 
LEU HD21 H N N 218 
LEU HD22 H N N 219 
LEU HD23 H N N 220 
LEU HXT  H N N 221 
LYS N    N N N 222 
LYS CA   C N S 223 
LYS C    C N N 224 
LYS O    O N N 225 
LYS CB   C N N 226 
LYS CG   C N N 227 
LYS CD   C N N 228 
LYS CE   C N N 229 
LYS NZ   N N N 230 
LYS OXT  O N N 231 
LYS H    H N N 232 
LYS H2   H N N 233 
LYS HA   H N N 234 
LYS HB2  H N N 235 
LYS HB3  H N N 236 
LYS HG2  H N N 237 
LYS HG3  H N N 238 
LYS HD2  H N N 239 
LYS HD3  H N N 240 
LYS HE2  H N N 241 
LYS HE3  H N N 242 
LYS HZ1  H N N 243 
LYS HZ2  H N N 244 
LYS HZ3  H N N 245 
LYS HXT  H N N 246 
MET N    N N N 247 
MET CA   C N S 248 
MET C    C N N 249 
MET O    O N N 250 
MET CB   C N N 251 
MET CG   C N N 252 
MET SD   S N N 253 
MET CE   C N N 254 
MET OXT  O N N 255 
MET H    H N N 256 
MET H2   H N N 257 
MET HA   H N N 258 
MET HB2  H N N 259 
MET HB3  H N N 260 
MET HG2  H N N 261 
MET HG3  H N N 262 
MET HE1  H N N 263 
MET HE2  H N N 264 
MET HE3  H N N 265 
MET HXT  H N N 266 
PHE N    N N N 267 
PHE CA   C N S 268 
PHE C    C N N 269 
PHE O    O N N 270 
PHE CB   C N N 271 
PHE CG   C Y N 272 
PHE CD1  C Y N 273 
PHE CD2  C Y N 274 
PHE CE1  C Y N 275 
PHE CE2  C Y N 276 
PHE CZ   C Y N 277 
PHE OXT  O N N 278 
PHE H    H N N 279 
PHE H2   H N N 280 
PHE HA   H N N 281 
PHE HB2  H N N 282 
PHE HB3  H N N 283 
PHE HD1  H N N 284 
PHE HD2  H N N 285 
PHE HE1  H N N 286 
PHE HE2  H N N 287 
PHE HZ   H N N 288 
PHE HXT  H N N 289 
PRO N    N N N 290 
PRO CA   C N S 291 
PRO C    C N N 292 
PRO O    O N N 293 
PRO CB   C N N 294 
PRO CG   C N N 295 
PRO CD   C N N 296 
PRO OXT  O N N 297 
PRO H    H N N 298 
PRO HA   H N N 299 
PRO HB2  H N N 300 
PRO HB3  H N N 301 
PRO HG2  H N N 302 
PRO HG3  H N N 303 
PRO HD2  H N N 304 
PRO HD3  H N N 305 
PRO HXT  H N N 306 
SER N    N N N 307 
SER CA   C N S 308 
SER C    C N N 309 
SER O    O N N 310 
SER CB   C N N 311 
SER OG   O N N 312 
SER OXT  O N N 313 
SER H    H N N 314 
SER H2   H N N 315 
SER HA   H N N 316 
SER HB2  H N N 317 
SER HB3  H N N 318 
SER HG   H N N 319 
SER HXT  H N N 320 
THR N    N N N 321 
THR CA   C N S 322 
THR C    C N N 323 
THR O    O N N 324 
THR CB   C N R 325 
THR OG1  O N N 326 
THR CG2  C N N 327 
THR OXT  O N N 328 
THR H    H N N 329 
THR H2   H N N 330 
THR HA   H N N 331 
THR HB   H N N 332 
THR HG1  H N N 333 
THR HG21 H N N 334 
THR HG22 H N N 335 
THR HG23 H N N 336 
THR HXT  H N N 337 
TRP N    N N N 338 
TRP CA   C N S 339 
TRP C    C N N 340 
TRP O    O N N 341 
TRP CB   C N N 342 
TRP CG   C Y N 343 
TRP CD1  C Y N 344 
TRP CD2  C Y N 345 
TRP NE1  N Y N 346 
TRP CE2  C Y N 347 
TRP CE3  C Y N 348 
TRP CZ2  C Y N 349 
TRP CZ3  C Y N 350 
TRP CH2  C Y N 351 
TRP OXT  O N N 352 
TRP H    H N N 353 
TRP H2   H N N 354 
TRP HA   H N N 355 
TRP HB2  H N N 356 
TRP HB3  H N N 357 
TRP HD1  H N N 358 
TRP HE1  H N N 359 
TRP HE3  H N N 360 
TRP HZ2  H N N 361 
TRP HZ3  H N N 362 
TRP HH2  H N N 363 
TRP HXT  H N N 364 
TYR N    N N N 365 
TYR CA   C N S 366 
TYR C    C N N 367 
TYR O    O N N 368 
TYR CB   C N N 369 
TYR CG   C Y N 370 
TYR CD1  C Y N 371 
TYR CD2  C Y N 372 
TYR CE1  C Y N 373 
TYR CE2  C Y N 374 
TYR CZ   C Y N 375 
TYR OH   O N N 376 
TYR OXT  O N N 377 
TYR H    H N N 378 
TYR H2   H N N 379 
TYR HA   H N N 380 
TYR HB2  H N N 381 
TYR HB3  H N N 382 
TYR HD1  H N N 383 
TYR HD2  H N N 384 
TYR HE1  H N N 385 
TYR HE2  H N N 386 
TYR HH   H N N 387 
TYR HXT  H N N 388 
URA N1   N N N 389 
URA C2   C N N 390 
URA O2   O N N 391 
URA N3   N N N 392 
URA C4   C N N 393 
URA O4   O N N 394 
URA C5   C N N 395 
URA C6   C N N 396 
URA HN1  H N N 397 
URA HN3  H N N 398 
URA H5   H N N 399 
URA H6   H N N 400 
VAL N    N N N 401 
VAL CA   C N S 402 
VAL C    C N N 403 
VAL O    O N N 404 
VAL CB   C N N 405 
VAL CG1  C N N 406 
VAL CG2  C N N 407 
VAL OXT  O N N 408 
VAL H    H N N 409 
VAL H2   H N N 410 
VAL HA   H N N 411 
VAL HB   H N N 412 
VAL HG11 H N N 413 
VAL HG12 H N N 414 
VAL HG13 H N N 415 
VAL HG21 H N N 416 
VAL HG22 H N N 417 
VAL HG23 H N N 418 
VAL HXT  H N N 419 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ACT C   O    doub N N 1   
ACT C   OXT  sing N N 2   
ACT C   CH3  sing N N 3   
ACT CH3 H1   sing N N 4   
ACT CH3 H2   sing N N 5   
ACT CH3 H3   sing N N 6   
ALA N   CA   sing N N 7   
ALA N   H    sing N N 8   
ALA N   H2   sing N N 9   
ALA CA  C    sing N N 10  
ALA CA  CB   sing N N 11  
ALA CA  HA   sing N N 12  
ALA C   O    doub N N 13  
ALA C   OXT  sing N N 14  
ALA CB  HB1  sing N N 15  
ALA CB  HB2  sing N N 16  
ALA CB  HB3  sing N N 17  
ALA OXT HXT  sing N N 18  
ARG N   CA   sing N N 19  
ARG N   H    sing N N 20  
ARG N   H2   sing N N 21  
ARG CA  C    sing N N 22  
ARG CA  CB   sing N N 23  
ARG CA  HA   sing N N 24  
ARG C   O    doub N N 25  
ARG C   OXT  sing N N 26  
ARG CB  CG   sing N N 27  
ARG CB  HB2  sing N N 28  
ARG CB  HB3  sing N N 29  
ARG CG  CD   sing N N 30  
ARG CG  HG2  sing N N 31  
ARG CG  HG3  sing N N 32  
ARG CD  NE   sing N N 33  
ARG CD  HD2  sing N N 34  
ARG CD  HD3  sing N N 35  
ARG NE  CZ   sing N N 36  
ARG NE  HE   sing N N 37  
ARG CZ  NH1  sing N N 38  
ARG CZ  NH2  doub N N 39  
ARG NH1 HH11 sing N N 40  
ARG NH1 HH12 sing N N 41  
ARG NH2 HH21 sing N N 42  
ARG NH2 HH22 sing N N 43  
ARG OXT HXT  sing N N 44  
ASN N   CA   sing N N 45  
ASN N   H    sing N N 46  
ASN N   H2   sing N N 47  
ASN CA  C    sing N N 48  
ASN CA  CB   sing N N 49  
ASN CA  HA   sing N N 50  
ASN C   O    doub N N 51  
ASN C   OXT  sing N N 52  
ASN CB  CG   sing N N 53  
ASN CB  HB2  sing N N 54  
ASN CB  HB3  sing N N 55  
ASN CG  OD1  doub N N 56  
ASN CG  ND2  sing N N 57  
ASN ND2 HD21 sing N N 58  
ASN ND2 HD22 sing N N 59  
ASN OXT HXT  sing N N 60  
ASP N   CA   sing N N 61  
ASP N   H    sing N N 62  
ASP N   H2   sing N N 63  
ASP CA  C    sing N N 64  
ASP CA  CB   sing N N 65  
ASP CA  HA   sing N N 66  
ASP C   O    doub N N 67  
ASP C   OXT  sing N N 68  
ASP CB  CG   sing N N 69  
ASP CB  HB2  sing N N 70  
ASP CB  HB3  sing N N 71  
ASP CG  OD1  doub N N 72  
ASP CG  OD2  sing N N 73  
ASP OD2 HD2  sing N N 74  
ASP OXT HXT  sing N N 75  
CYS N   CA   sing N N 76  
CYS N   H    sing N N 77  
CYS N   H2   sing N N 78  
CYS CA  C    sing N N 79  
CYS CA  CB   sing N N 80  
CYS CA  HA   sing N N 81  
CYS C   O    doub N N 82  
CYS C   OXT  sing N N 83  
CYS CB  SG   sing N N 84  
CYS CB  HB2  sing N N 85  
CYS CB  HB3  sing N N 86  
CYS SG  HG   sing N N 87  
CYS OXT HXT  sing N N 88  
EDO C1  O1   sing N N 89  
EDO C1  C2   sing N N 90  
EDO C1  H11  sing N N 91  
EDO C1  H12  sing N N 92  
EDO O1  HO1  sing N N 93  
EDO C2  O2   sing N N 94  
EDO C2  H21  sing N N 95  
EDO C2  H22  sing N N 96  
EDO O2  HO2  sing N N 97  
GLN N   CA   sing N N 98  
GLN N   H    sing N N 99  
GLN N   H2   sing N N 100 
GLN CA  C    sing N N 101 
GLN CA  CB   sing N N 102 
GLN CA  HA   sing N N 103 
GLN C   O    doub N N 104 
GLN C   OXT  sing N N 105 
GLN CB  CG   sing N N 106 
GLN CB  HB2  sing N N 107 
GLN CB  HB3  sing N N 108 
GLN CG  CD   sing N N 109 
GLN CG  HG2  sing N N 110 
GLN CG  HG3  sing N N 111 
GLN CD  OE1  doub N N 112 
GLN CD  NE2  sing N N 113 
GLN NE2 HE21 sing N N 114 
GLN NE2 HE22 sing N N 115 
GLN OXT HXT  sing N N 116 
GLU N   CA   sing N N 117 
GLU N   H    sing N N 118 
GLU N   H2   sing N N 119 
GLU CA  C    sing N N 120 
GLU CA  CB   sing N N 121 
GLU CA  HA   sing N N 122 
GLU C   O    doub N N 123 
GLU C   OXT  sing N N 124 
GLU CB  CG   sing N N 125 
GLU CB  HB2  sing N N 126 
GLU CB  HB3  sing N N 127 
GLU CG  CD   sing N N 128 
GLU CG  HG2  sing N N 129 
GLU CG  HG3  sing N N 130 
GLU CD  OE1  doub N N 131 
GLU CD  OE2  sing N N 132 
GLU OE2 HE2  sing N N 133 
GLU OXT HXT  sing N N 134 
GLY N   CA   sing N N 135 
GLY N   H    sing N N 136 
GLY N   H2   sing N N 137 
GLY CA  C    sing N N 138 
GLY CA  HA2  sing N N 139 
GLY CA  HA3  sing N N 140 
GLY C   O    doub N N 141 
GLY C   OXT  sing N N 142 
GLY OXT HXT  sing N N 143 
HIS N   CA   sing N N 144 
HIS N   H    sing N N 145 
HIS N   H2   sing N N 146 
HIS CA  C    sing N N 147 
HIS CA  CB   sing N N 148 
HIS CA  HA   sing N N 149 
HIS C   O    doub N N 150 
HIS C   OXT  sing N N 151 
HIS CB  CG   sing N N 152 
HIS CB  HB2  sing N N 153 
HIS CB  HB3  sing N N 154 
HIS CG  ND1  sing Y N 155 
HIS CG  CD2  doub Y N 156 
HIS ND1 CE1  doub Y N 157 
HIS ND1 HD1  sing N N 158 
HIS CD2 NE2  sing Y N 159 
HIS CD2 HD2  sing N N 160 
HIS CE1 NE2  sing Y N 161 
HIS CE1 HE1  sing N N 162 
HIS NE2 HE2  sing N N 163 
HIS OXT HXT  sing N N 164 
HOH O   H1   sing N N 165 
HOH O   H2   sing N N 166 
ILE N   CA   sing N N 167 
ILE N   H    sing N N 168 
ILE N   H2   sing N N 169 
ILE CA  C    sing N N 170 
ILE CA  CB   sing N N 171 
ILE CA  HA   sing N N 172 
ILE C   O    doub N N 173 
ILE C   OXT  sing N N 174 
ILE CB  CG1  sing N N 175 
ILE CB  CG2  sing N N 176 
ILE CB  HB   sing N N 177 
ILE CG1 CD1  sing N N 178 
ILE CG1 HG12 sing N N 179 
ILE CG1 HG13 sing N N 180 
ILE CG2 HG21 sing N N 181 
ILE CG2 HG22 sing N N 182 
ILE CG2 HG23 sing N N 183 
ILE CD1 HD11 sing N N 184 
ILE CD1 HD12 sing N N 185 
ILE CD1 HD13 sing N N 186 
ILE OXT HXT  sing N N 187 
LEU N   CA   sing N N 188 
LEU N   H    sing N N 189 
LEU N   H2   sing N N 190 
LEU CA  C    sing N N 191 
LEU CA  CB   sing N N 192 
LEU CA  HA   sing N N 193 
LEU C   O    doub N N 194 
LEU C   OXT  sing N N 195 
LEU CB  CG   sing N N 196 
LEU CB  HB2  sing N N 197 
LEU CB  HB3  sing N N 198 
LEU CG  CD1  sing N N 199 
LEU CG  CD2  sing N N 200 
LEU CG  HG   sing N N 201 
LEU CD1 HD11 sing N N 202 
LEU CD1 HD12 sing N N 203 
LEU CD1 HD13 sing N N 204 
LEU CD2 HD21 sing N N 205 
LEU CD2 HD22 sing N N 206 
LEU CD2 HD23 sing N N 207 
LEU OXT HXT  sing N N 208 
LYS N   CA   sing N N 209 
LYS N   H    sing N N 210 
LYS N   H2   sing N N 211 
LYS CA  C    sing N N 212 
LYS CA  CB   sing N N 213 
LYS CA  HA   sing N N 214 
LYS C   O    doub N N 215 
LYS C   OXT  sing N N 216 
LYS CB  CG   sing N N 217 
LYS CB  HB2  sing N N 218 
LYS CB  HB3  sing N N 219 
LYS CG  CD   sing N N 220 
LYS CG  HG2  sing N N 221 
LYS CG  HG3  sing N N 222 
LYS CD  CE   sing N N 223 
LYS CD  HD2  sing N N 224 
LYS CD  HD3  sing N N 225 
LYS CE  NZ   sing N N 226 
LYS CE  HE2  sing N N 227 
LYS CE  HE3  sing N N 228 
LYS NZ  HZ1  sing N N 229 
LYS NZ  HZ2  sing N N 230 
LYS NZ  HZ3  sing N N 231 
LYS OXT HXT  sing N N 232 
MET N   CA   sing N N 233 
MET N   H    sing N N 234 
MET N   H2   sing N N 235 
MET CA  C    sing N N 236 
MET CA  CB   sing N N 237 
MET CA  HA   sing N N 238 
MET C   O    doub N N 239 
MET C   OXT  sing N N 240 
MET CB  CG   sing N N 241 
MET CB  HB2  sing N N 242 
MET CB  HB3  sing N N 243 
MET CG  SD   sing N N 244 
MET CG  HG2  sing N N 245 
MET CG  HG3  sing N N 246 
MET SD  CE   sing N N 247 
MET CE  HE1  sing N N 248 
MET CE  HE2  sing N N 249 
MET CE  HE3  sing N N 250 
MET OXT HXT  sing N N 251 
PHE N   CA   sing N N 252 
PHE N   H    sing N N 253 
PHE N   H2   sing N N 254 
PHE CA  C    sing N N 255 
PHE CA  CB   sing N N 256 
PHE CA  HA   sing N N 257 
PHE C   O    doub N N 258 
PHE C   OXT  sing N N 259 
PHE CB  CG   sing N N 260 
PHE CB  HB2  sing N N 261 
PHE CB  HB3  sing N N 262 
PHE CG  CD1  doub Y N 263 
PHE CG  CD2  sing Y N 264 
PHE CD1 CE1  sing Y N 265 
PHE CD1 HD1  sing N N 266 
PHE CD2 CE2  doub Y N 267 
PHE CD2 HD2  sing N N 268 
PHE CE1 CZ   doub Y N 269 
PHE CE1 HE1  sing N N 270 
PHE CE2 CZ   sing Y N 271 
PHE CE2 HE2  sing N N 272 
PHE CZ  HZ   sing N N 273 
PHE OXT HXT  sing N N 274 
PRO N   CA   sing N N 275 
PRO N   CD   sing N N 276 
PRO N   H    sing N N 277 
PRO CA  C    sing N N 278 
PRO CA  CB   sing N N 279 
PRO CA  HA   sing N N 280 
PRO C   O    doub N N 281 
PRO C   OXT  sing N N 282 
PRO CB  CG   sing N N 283 
PRO CB  HB2  sing N N 284 
PRO CB  HB3  sing N N 285 
PRO CG  CD   sing N N 286 
PRO CG  HG2  sing N N 287 
PRO CG  HG3  sing N N 288 
PRO CD  HD2  sing N N 289 
PRO CD  HD3  sing N N 290 
PRO OXT HXT  sing N N 291 
SER N   CA   sing N N 292 
SER N   H    sing N N 293 
SER N   H2   sing N N 294 
SER CA  C    sing N N 295 
SER CA  CB   sing N N 296 
SER CA  HA   sing N N 297 
SER C   O    doub N N 298 
SER C   OXT  sing N N 299 
SER CB  OG   sing N N 300 
SER CB  HB2  sing N N 301 
SER CB  HB3  sing N N 302 
SER OG  HG   sing N N 303 
SER OXT HXT  sing N N 304 
THR N   CA   sing N N 305 
THR N   H    sing N N 306 
THR N   H2   sing N N 307 
THR CA  C    sing N N 308 
THR CA  CB   sing N N 309 
THR CA  HA   sing N N 310 
THR C   O    doub N N 311 
THR C   OXT  sing N N 312 
THR CB  OG1  sing N N 313 
THR CB  CG2  sing N N 314 
THR CB  HB   sing N N 315 
THR OG1 HG1  sing N N 316 
THR CG2 HG21 sing N N 317 
THR CG2 HG22 sing N N 318 
THR CG2 HG23 sing N N 319 
THR OXT HXT  sing N N 320 
TRP N   CA   sing N N 321 
TRP N   H    sing N N 322 
TRP N   H2   sing N N 323 
TRP CA  C    sing N N 324 
TRP CA  CB   sing N N 325 
TRP CA  HA   sing N N 326 
TRP C   O    doub N N 327 
TRP C   OXT  sing N N 328 
TRP CB  CG   sing N N 329 
TRP CB  HB2  sing N N 330 
TRP CB  HB3  sing N N 331 
TRP CG  CD1  doub Y N 332 
TRP CG  CD2  sing Y N 333 
TRP CD1 NE1  sing Y N 334 
TRP CD1 HD1  sing N N 335 
TRP CD2 CE2  doub Y N 336 
TRP CD2 CE3  sing Y N 337 
TRP NE1 CE2  sing Y N 338 
TRP NE1 HE1  sing N N 339 
TRP CE2 CZ2  sing Y N 340 
TRP CE3 CZ3  doub Y N 341 
TRP CE3 HE3  sing N N 342 
TRP CZ2 CH2  doub Y N 343 
TRP CZ2 HZ2  sing N N 344 
TRP CZ3 CH2  sing Y N 345 
TRP CZ3 HZ3  sing N N 346 
TRP CH2 HH2  sing N N 347 
TRP OXT HXT  sing N N 348 
TYR N   CA   sing N N 349 
TYR N   H    sing N N 350 
TYR N   H2   sing N N 351 
TYR CA  C    sing N N 352 
TYR CA  CB   sing N N 353 
TYR CA  HA   sing N N 354 
TYR C   O    doub N N 355 
TYR C   OXT  sing N N 356 
TYR CB  CG   sing N N 357 
TYR CB  HB2  sing N N 358 
TYR CB  HB3  sing N N 359 
TYR CG  CD1  doub Y N 360 
TYR CG  CD2  sing Y N 361 
TYR CD1 CE1  sing Y N 362 
TYR CD1 HD1  sing N N 363 
TYR CD2 CE2  doub Y N 364 
TYR CD2 HD2  sing N N 365 
TYR CE1 CZ   doub Y N 366 
TYR CE1 HE1  sing N N 367 
TYR CE2 CZ   sing Y N 368 
TYR CE2 HE2  sing N N 369 
TYR CZ  OH   sing N N 370 
TYR OH  HH   sing N N 371 
TYR OXT HXT  sing N N 372 
URA N1  C2   sing N N 373 
URA N1  C6   sing N N 374 
URA N1  HN1  sing N N 375 
URA C2  O2   doub N N 376 
URA C2  N3   sing N N 377 
URA N3  C4   sing N N 378 
URA N3  HN3  sing N N 379 
URA C4  O4   doub N N 380 
URA C4  C5   sing N N 381 
URA C5  C6   doub N N 382 
URA C5  H5   sing N N 383 
URA C6  H6   sing N N 384 
VAL N   CA   sing N N 385 
VAL N   H    sing N N 386 
VAL N   H2   sing N N 387 
VAL CA  C    sing N N 388 
VAL CA  CB   sing N N 389 
VAL CA  HA   sing N N 390 
VAL C   O    doub N N 391 
VAL C   OXT  sing N N 392 
VAL CB  CG1  sing N N 393 
VAL CB  CG2  sing N N 394 
VAL CB  HB   sing N N 395 
VAL CG1 HG11 sing N N 396 
VAL CG1 HG12 sing N N 397 
VAL CG1 HG13 sing N N 398 
VAL CG2 HG21 sing N N 399 
VAL CG2 HG22 sing N N 400 
VAL CG2 HG23 sing N N 401 
VAL OXT HXT  sing N N 402 
# 
_pdbx_audit_support.funding_organization   'German Research Foundation (DFG)' 
_pdbx_audit_support.country                Germany 
_pdbx_audit_support.grant_number           464366151 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'in silico model' 
_pdbx_initial_refinement_model.source_name      AlphaFold 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 1 21 1' 
_space_group.name_Hall        'P 2yb' 
_space_group.IT_number        4 
_space_group.crystal_system   monoclinic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9HVJ 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.028571 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.001093 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.010743 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.022549 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . HIS A 1 7   ? 9.11168   -39.88308 -5.28302  1.000 32.06452 ? 18  HIS A N   1 
ATOM   2    C CA  . HIS A 1 7   ? 9.93683   -38.79589 -4.76072  1.000 31.86977 ? 18  HIS A CA  1 
ATOM   3    C C   . HIS A 1 7   ? 9.48124   -37.42991 -5.28357  1.000 29.50464 ? 18  HIS A C   1 
ATOM   4    O O   . HIS A 1 7   ? 10.29823  -36.63134 -5.75907  1.000 31.71529 ? 18  HIS A O   1 
ATOM   5    C CB  . HIS A 1 7   ? 11.40898  -39.03268 -5.10644  1.000 22.79748 ? 18  HIS A CB  1 
ATOM   6    C CG  . HIS A 1 7   ? 11.96715  -40.29079 -4.52101  1.000 20.45871 ? 18  HIS A CG  1 
ATOM   7    N ND1 . HIS A 1 7   ? 12.35665  -41.35955 -5.29902  1.000 22.60878 ? 18  HIS A ND1 1 
ATOM   8    C CD2 . HIS A 1 7   ? 12.18779  -40.65976 -3.23659  1.000 18.40253 ? 18  HIS A CD2 1 
ATOM   9    C CE1 . HIS A 1 7   ? 12.80047  -42.32928 -4.51999  1.000 23.83433 ? 18  HIS A CE1 1 
ATOM   10   N NE2 . HIS A 1 7   ? 12.70503  -41.93081 -3.26303  1.000 19.32814 ? 18  HIS A NE2 1 
ATOM   11   N N   . HIS A 1 8   ? 8.17685   -37.17138 -5.20536  1.000 24.18039 ? 19  HIS A N   1 
ATOM   12   C CA  . HIS A 1 8   ? 7.59928   -35.86969 -5.53365  1.000 21.23535 ? 19  HIS A CA  1 
ATOM   13   C C   . HIS A 1 8   ? 7.12705   -35.28215 -4.20978  1.000 15.69769 ? 19  HIS A C   1 
ATOM   14   O O   . HIS A 1 8   ? 5.96501   -35.40871 -3.82170  1.000 23.39429 ? 19  HIS A O   1 
ATOM   15   C CB  . HIS A 1 8   ? 6.43368   -35.97955 -6.53567  1.000 20.18066 ? 19  HIS A CB  1 
ATOM   16   C CG  . HIS A 1 8   ? 6.84781   -36.40378 -7.90921  1.000 24.79999 ? 19  HIS A CG  1 
ATOM   17   N ND1 . HIS A 1 8   ? 7.90038   -37.26324 -8.13679  1.000 31.55323 ? 19  HIS A ND1 1 
ATOM   18   C CD2 . HIS A 1 8   ? 6.34505   -36.09225 -9.12832  1.000 27.49134 ? 19  HIS A CD2 1 
ATOM   19   C CE1 . HIS A 1 8   ? 8.03326   -37.46050 -9.43714  1.000 26.93196 ? 19  HIS A CE1 1 
ATOM   20   N NE2 . HIS A 1 8   ? 7.10101   -36.76176 -10.06147 1.000 30.50259 ? 19  HIS A NE2 1 
ATOM   21   N N   . HIS A 1 9   ? 8.05105   -34.65096 -3.50672  1.000 13.46292 ? 20  HIS A N   1 
ATOM   22   C CA  . HIS A 1 9   ? 7.74998   -34.14164 -2.18414  1.000 12.89453 ? 20  HIS A CA  1 
ATOM   23   C C   . HIS A 1 9   ? 6.86502   -32.90953 -2.29592  1.000 13.48572 ? 20  HIS A C   1 
ATOM   24   O O   . HIS A 1 9   ? 6.99890   -32.10401 -3.22591  1.000 14.40436 ? 20  HIS A O   1 
ATOM   25   C CB  . HIS A 1 9   ? 9.05784   -33.80774 -1.47398  1.000 18.57165 ? 20  HIS A CB  1 
ATOM   26   C CG  . HIS A 1 9   ? 8.87528   -33.16702 -0.14040  1.000 18.21563 ? 20  HIS A CG  1 
ATOM   27   N ND1 . HIS A 1 9   ? 8.43790   -33.86679 0.96224   1.000 17.92824 ? 20  HIS A ND1 1 
ATOM   28   C CD2 . HIS A 1 9   ? 9.09154   -31.89710 0.27806   1.000 24.23568 ? 20  HIS A CD2 1 
ATOM   29   C CE1 . HIS A 1 9   ? 8.37824   -33.05097 1.99999   1.000 20.79119 ? 20  HIS A CE1 1 
ATOM   30   N NE2 . HIS A 1 9   ? 8.76931   -31.85104 1.61135   1.000 26.60044 ? 20  HIS A NE2 1 
ATOM   31   N N   . HIS A 1 10  ? 5.93393   -32.78012 -1.36238  1.000 12.25121 ? 21  HIS A N   1 
ATOM   32   C CA  . HIS A 1 10  ? 5.07024   -31.61428 -1.28051  1.000 13.34404 ? 21  HIS A CA  1 
ATOM   33   C C   . HIS A 1 10  ? 5.21615   -30.97000 0.08967   1.000 13.60996 ? 21  HIS A C   1 
ATOM   34   O O   . HIS A 1 10  ? 5.46087   -31.65410 1.09199   1.000 17.40143 ? 21  HIS A O   1 
ATOM   35   C CB  . HIS A 1 10  ? 3.61449   -32.02578 -1.48521  1.000 10.26978 ? 21  HIS A CB  1 
ATOM   36   C CG  . HIS A 1 10  ? 3.35538   -32.61616 -2.83228  1.000 12.67287 ? 21  HIS A CG  1 
ATOM   37   N ND1 . HIS A 1 10  ? 3.27456   -31.85111 -3.97690  1.000 28.00676 ? 21  HIS A ND1 1 
ATOM   38   C CD2 . HIS A 1 10  ? 3.22557   -33.90309 -3.22620  1.000 13.07216 ? 21  HIS A CD2 1 
ATOM   39   C CE1 . HIS A 1 10  ? 3.06883   -32.64225 -5.01462  1.000 22.63714 ? 21  HIS A CE1 1 
ATOM   40   N NE2 . HIS A 1 10  ? 3.03487   -33.89084 -4.58662  1.000 21.97222 ? 21  HIS A NE2 1 
ATOM   41   N N   . SER A 1 11  ? 5.05173   -29.64884 0.12433   1.000 13.84522 ? 22  SER A N   1 
ATOM   42   C CA  . SER A 1 11  ? 5.11866   -28.92079 1.38509   1.000 13.30778 ? 22  SER A CA  1 
ATOM   43   C C   . SER A 1 11  ? 3.93510   -29.28093 2.28086   1.000 17.26790 ? 22  SER A C   1 
ATOM   44   O O   . SER A 1 11  ? 2.90555   -29.78678 1.82403   1.000 13.72682 ? 22  SER A O   1 
ATOM   45   C CB  . SER A 1 11  ? 5.15576   -27.41255 1.14395   1.000 15.32336 ? 22  SER A CB  1 
ATOM   46   O OG  . SER A 1 11  ? 4.06337   -26.98282 0.34515   1.000 18.65097 ? 22  SER A OG  1 
ATOM   47   N N   . SER A 1 12  ? 4.09219   -29.00021 3.57307   1.000 16.54785 ? 23  SER A N   1 
ATOM   48   C CA  A SER A 1 12  ? 3.06704   -29.36170 4.54234   0.306 16.36127 ? 23  SER A CA  1 
ATOM   49   C CA  B SER A 1 12  ? 3.07104   -29.35334 4.55123   0.428 16.34540 ? 23  SER A CA  1 
ATOM   50   C CA  C SER A 1 12  ? 3.06985   -29.35666 4.54729   0.266 16.36796 ? 23  SER A CA  1 
ATOM   51   C C   . SER A 1 12  ? 1.81887   -28.50546 4.36084   1.000 15.31975 ? 23  SER A C   1 
ATOM   52   O O   . SER A 1 12  ? 1.89369   -27.30660 4.06837   1.000 18.35488 ? 23  SER A O   1 
ATOM   53   C CB  A SER A 1 12  ? 3.60420   -29.22037 5.96815   0.306 19.84967 ? 23  SER A CB  1 
ATOM   54   C CB  B SER A 1 12  ? 3.61571   -29.16183 5.96762   0.428 19.87040 ? 23  SER A CB  1 
ATOM   55   C CB  C SER A 1 12  ? 3.61127   -29.17546 5.96466   0.266 19.84273 ? 23  SER A CB  1 
ATOM   56   O OG  A SER A 1 12  ? 4.67176   -30.12438 6.20593   0.306 15.77510 ? 23  SER A OG  1 
ATOM   57   O OG  B SER A 1 12  ? 3.72977   -27.78555 6.29014   0.428 18.31281 ? 23  SER A OG  1 
ATOM   58   O OG  C SER A 1 12  ? 2.65137   -29.57074 6.92667   0.266 20.40632 ? 23  SER A OG  1 
ATOM   59   N N   . GLY A 1 13  ? 0.65758   -29.13472 4.53147   1.000 15.06633 ? 24  GLY A N   1 
ATOM   60   C CA  . GLY A 1 13  ? -0.60082  -28.42298 4.45011   1.000 15.55215 ? 24  GLY A CA  1 
ATOM   61   C C   . GLY A 1 13  ? -1.19943  -28.27921 5.83588   1.000 18.38117 ? 24  GLY A C   1 
ATOM   62   O O   . GLY A 1 13  ? -0.46519  -28.25843 6.82663   1.000 21.84707 ? 24  GLY A O   1 
ATOM   63   N N   . LEU A 1 14  ? -2.52879  -28.20862 5.91506   1.000 16.79170 ? 25  LEU A N   1 
ATOM   64   C CA  A LEU A 1 14  ? -3.19674  -28.06606 7.20243   0.558 17.13974 ? 25  LEU A CA  1 
ATOM   65   C CA  B LEU A 1 14  ? -3.21134  -28.07600 7.19710   0.442 17.15487 ? 25  LEU A CA  1 
ATOM   66   C C   . LEU A 1 14  ? -2.78792  -29.19617 8.13815   1.000 15.54752 ? 25  LEU A C   1 
ATOM   67   O O   . LEU A 1 14  ? -2.83381  -30.37767 7.78001   1.000 16.79493 ? 25  LEU A O   1 
ATOM   68   C CB  A LEU A 1 14  ? -4.71381  -28.03533 7.00354   0.558 14.87301 ? 25  LEU A CB  1 
ATOM   69   C CB  B LEU A 1 14  ? -4.72121  -28.12647 6.95351   0.442 14.92512 ? 25  LEU A CB  1 
ATOM   70   C CG  A LEU A 1 14  ? -5.22109  -26.79229 6.26980   0.558 13.76409 ? 25  LEU A CG  1 
ATOM   71   C CG  B LEU A 1 14  ? -5.67781  -27.84478 8.10632   0.442 17.47873 ? 25  LEU A CG  1 
ATOM   72   C CD1 A LEU A 1 14  ? -6.63651  -27.00363 5.76309   0.558 14.53311 ? 25  LEU A CD1 1 
ATOM   73   C CD1 B LEU A 1 14  ? -5.42218  -26.46537 8.68427   0.442 24.32842 ? 25  LEU A CD1 1 
ATOM   74   C CD2 A LEU A 1 14  ? -5.15503  -25.56334 7.16327   0.558 19.15460 ? 25  LEU A CD2 1 
ATOM   75   C CD2 B LEU A 1 14  ? -7.09371  -27.95899 7.57556   0.442 17.75628 ? 25  LEU A CD2 1 
ATOM   76   N N   . VAL A 1 15  ? -2.37353  -28.82292 9.34239   1.000 22.57224 ? 26  VAL A N   1 
ATOM   77   C CA  . VAL A 1 15  ? -1.75056  -29.74949 10.28104  1.000 21.18430 ? 26  VAL A CA  1 
ATOM   78   C C   . VAL A 1 15  ? -2.83743  -30.32223 11.18616  1.000 22.88006 ? 26  VAL A C   1 
ATOM   79   O O   . VAL A 1 15  ? -3.54677  -29.54522 11.84646  1.000 23.55547 ? 26  VAL A O   1 
ATOM   80   C CB  . VAL A 1 15  ? -0.67464  -29.04102 11.11039  1.000 30.71517 ? 26  VAL A CB  1 
ATOM   81   C CG1 . VAL A 1 15  ? -0.01645  -30.02925 12.06022  1.000 28.94655 ? 26  VAL A CG1 1 
ATOM   82   C CG2 . VAL A 1 15  ? 0.34891   -28.38187 10.19009  1.000 27.85840 ? 26  VAL A CG2 1 
ATOM   83   N N   . PRO A 1 16  ? -3.00681  -31.64134 11.23916  1.000 23.08431 ? 27  PRO A N   1 
ATOM   84   C CA  . PRO A 1 16  ? -3.99007  -32.22295 12.16490  1.000 26.87070 ? 27  PRO A CA  1 
ATOM   85   C C   . PRO A 1 16  ? -3.62215  -31.92686 13.61242  1.000 32.90085 ? 27  PRO A C   1 
ATOM   86   O O   . PRO A 1 16  ? -2.44456  -31.89906 13.97782  1.000 34.64227 ? 27  PRO A O   1 
ATOM   87   C CB  . PRO A 1 16  ? -3.90879  -33.72885 11.88259  1.000 30.40630 ? 27  PRO A CB  1 
ATOM   88   C CG  . PRO A 1 16  ? -2.99527  -33.91004 10.71255  1.000 27.57976 ? 27  PRO A CG  1 
ATOM   89   C CD  . PRO A 1 16  ? -2.56003  -32.58358 10.19961  1.000 26.42661 ? 27  PRO A CD  1 
ATOM   90   N N   . ARG A 1 17  ? -4.64449  -31.70762 14.44081  1.000 33.31199 ? 28  ARG A N   1 
ATOM   91   C CA  . ARG A 1 17  ? -4.41034  -31.50266 15.86730  1.000 41.18595 ? 28  ARG A CA  1 
ATOM   92   C C   . ARG A 1 17  ? -3.77885  -32.74748 16.47837  1.000 41.71108 ? 28  ARG A C   1 
ATOM   93   O O   . ARG A 1 17  ? -4.25181  -33.86818 16.26387  1.000 35.27376 ? 28  ARG A O   1 
ATOM   94   C CB  . ARG A 1 17  ? -5.71863  -31.17459 16.59255  1.000 39.46610 ? 28  ARG A CB  1 
ATOM   95   C CG  . ARG A 1 17  ? -6.32147  -29.81502 16.25576  1.000 59.17632 ? 28  ARG A CG  1 
ATOM   96   C CD  . ARG A 1 17  ? -7.59231  -29.55863 17.06957  1.000 76.94307 ? 28  ARG A CD  1 
ATOM   97   N NE  . ARG A 1 17  ? -8.23993  -28.29721 16.72136  1.000 91.31676 ? 28  ARG A NE  1 
ATOM   98   C CZ  . ARG A 1 17  ? -9.41219  -27.89732 17.19886  1.000 85.79120 ? 28  ARG A CZ  1 
ATOM   99   N NH1 . ARG A 1 17  ? -10.09835 -28.63644 18.05582  1.000 81.92467 ? 28  ARG A NH1 1 
ATOM   100  N NH2 . ARG A 1 17  ? -9.90693  -26.72436 16.80999  1.000 67.56794 ? 28  ARG A NH2 1 
ATOM   101  N N   . GLY A 1 18  ? -2.69974  -32.54640 17.23304  1.000 40.13398 ? 29  GLY A N   1 
ATOM   102  C CA  . GLY A 1 18  ? -2.01313  -33.64514 17.87876  1.000 44.46234 ? 29  GLY A CA  1 
ATOM   103  C C   . GLY A 1 18  ? -0.85465  -34.22942 17.10525  1.000 47.11322 ? 29  GLY A C   1 
ATOM   104  O O   . GLY A 1 18  ? -0.52609  -35.40510 17.29945  1.000 47.13323 ? 29  GLY A O   1 
ATOM   105  N N   . SER A 1 19  ? -0.21945  -33.45049 16.23538  1.000 52.61915 ? 30  SER A N   1 
ATOM   106  C CA  . SER A 1 19  ? 0.89561   -33.94911 15.43444  1.000 49.02652 ? 30  SER A CA  1 
ATOM   107  C C   . SER A 1 19  ? 2.20789   -33.86493 16.20841  1.000 51.47108 ? 30  SER A C   1 
ATOM   108  O O   . SER A 1 19  ? 3.12730   -34.65266 15.98392  1.000 54.52495 ? 30  SER A O   1 
ATOM   109  C CB  . SER A 1 19  ? 1.00677   -33.16051 14.12755  1.000 51.96530 ? 30  SER A CB  1 
ATOM   110  O OG  . SER A 1 19  ? -0.07644  -33.45456 13.26377  1.000 39.83105 ? 30  SER A OG  1 
ATOM   111  N N   . SER A 1 24  ? 12.28005  -36.90307 19.08864  1.000 23.66473 ? 35  SER A N   1 
ATOM   112  C CA  . SER A 1 24  ? 13.15476  -36.61937 20.21948  1.000 20.10639 ? 35  SER A CA  1 
ATOM   113  C C   . SER A 1 24  ? 13.19710  -35.13556 20.57380  1.000 20.85164 ? 35  SER A C   1 
ATOM   114  O O   . SER A 1 24  ? 12.81723  -34.28404 19.76469  1.000 16.56721 ? 35  SER A O   1 
ATOM   115  C CB  . SER A 1 24  ? 14.57356  -37.11660 19.93288  1.000 18.63923 ? 35  SER A CB  1 
ATOM   116  O OG  . SER A 1 24  ? 15.26861  -36.23454 19.06361  1.000 22.09067 ? 35  SER A OG  1 
ATOM   117  N N   . TYR A 1 25  ? 13.68273  -34.84292 21.78621  1.000 15.23043 ? 36  TYR A N   1 
ATOM   118  C CA  . TYR A 1 25  ? 13.83574  -33.45547 22.21549  1.000 12.49922 ? 36  TYR A CA  1 
ATOM   119  C C   . TYR A 1 25  ? 14.80612  -32.71701 21.30209  1.000 11.05638 ? 36  TYR A C   1 
ATOM   120  O O   . TYR A 1 25  ? 14.54659  -31.57121 20.91060  1.000 11.13393 ? 36  TYR A O   1 
ATOM   121  C CB  . TYR A 1 25  ? 14.31465  -33.40077 23.67336  1.000 14.86630 ? 36  TYR A CB  1 
ATOM   122  C CG  . TYR A 1 25  ? 14.32980  -32.01533 24.27076  1.000 13.18192 ? 36  TYR A CG  1 
ATOM   123  C CD1 . TYR A 1 25  ? 15.42192  -31.16988 24.10461  1.000 12.18428 ? 36  TYR A CD1 1 
ATOM   124  C CD2 . TYR A 1 25  ? 13.24936  -31.54140 25.00595  1.000 13.50297 ? 36  TYR A CD2 1 
ATOM   125  C CE1 . TYR A 1 25  ? 15.43312  -29.89790 24.64439  1.000 12.97914 ? 36  TYR A CE1 1 
ATOM   126  C CE2 . TYR A 1 25  ? 13.25664  -30.27834 25.54589  1.000 13.83695 ? 36  TYR A CE2 1 
ATOM   127  C CZ  . TYR A 1 25  ? 14.35316  -29.45694 25.35774  1.000 14.46247 ? 36  TYR A CZ  1 
ATOM   128  O OH  . TYR A 1 25  ? 14.38704  -28.19403 25.88884  1.000 18.63623 ? 36  TYR A OH  1 
ATOM   129  N N   . GLU A 1 26  ? 15.91950  -33.36836 20.93671  1.000 14.98388 ? 37  GLU A N   1 
ATOM   130  C CA  . GLU A 1 26  ? 16.88923  -32.76188 20.02525  1.000 16.08887 ? 37  GLU A CA  1 
ATOM   131  C C   . GLU A 1 26  ? 16.27202  -32.46859 18.65987  1.000 14.42449 ? 37  GLU A C   1 
ATOM   132  O O   . GLU A 1 26  ? 16.50757  -31.39337 18.09184  1.000 12.86718 ? 37  GLU A O   1 
ATOM   133  C CB  . GLU A 1 26  ? 18.10160  -33.68163 19.86828  1.000 19.64584 ? 37  GLU A CB  1 
ATOM   134  C CG  . GLU A 1 26  ? 18.64316  -34.22648 21.18387  1.000 32.50699 ? 37  GLU A CG  1 
ATOM   135  C CD  . GLU A 1 26  ? 18.07747  -35.60274 21.53094  1.000 41.48064 ? 37  GLU A CD  1 
ATOM   136  O OE1 . GLU A 1 26  ? 17.14370  -35.67391 22.36509  1.000 37.67030 ? 37  GLU A OE1 1 
ATOM   137  O OE2 . GLU A 1 26  ? 18.56400  -36.61078 20.96073  1.000 47.90203 ? 37  GLU A OE2 1 
ATOM   138  N N   . ASP A 1 27  ? 15.49019  -33.40779 18.10837  1.000 14.06760 ? 38  ASP A N   1 
ATOM   139  C CA  . ASP A 1 27  ? 14.80175  -33.13726 16.84248  1.000 12.71809 ? 38  ASP A CA  1 
ATOM   140  C C   . ASP A 1 27  ? 13.85930  -31.94318 16.95682  1.000 9.52528  ? 38  ASP A C   1 
ATOM   141  O O   . ASP A 1 27  ? 13.75786  -31.13025 16.03187  1.000 10.89201 ? 38  ASP A O   1 
ATOM   142  C CB  . ASP A 1 27  ? 14.04533  -34.36591 16.32042  1.000 17.08084 ? 38  ASP A CB  1 
ATOM   143  C CG  . ASP A 1 27  ? 14.96445  -35.49443 15.90639  1.000 33.47397 ? 38  ASP A CG  1 
ATOM   144  O OD1 . ASP A 1 27  ? 16.11939  -35.20593 15.53256  1.000 36.07885 ? 38  ASP A OD1 1 
ATOM   145  O OD2 . ASP A 1 27  ? 14.52060  -36.66251 15.91809  1.000 41.75789 ? 38  ASP A OD2 1 
ATOM   146  N N   . SER A 1 28  ? 13.17110  -31.80857 18.08990  1.000 10.03905 ? 39  SER A N   1 
ATOM   147  C CA  . SER A 1 28  ? 12.27094  -30.66838 18.26123  1.000 9.96072  ? 39  SER A CA  1 
ATOM   148  C C   . SER A 1 28  ? 13.03166  -29.34757 18.36349  1.000 8.56754  ? 39  SER A C   1 
ATOM   149  O O   . SER A 1 28  ? 12.59138  -28.32904 17.80718  1.000 8.83674  ? 39  SER A O   1 
ATOM   150  C CB  . SER A 1 28  ? 11.37830  -30.88995 19.48403  1.000 11.97987 ? 39  SER A CB  1 
ATOM   151  O OG  . SER A 1 28  ? 10.54069  -32.01674 19.29572  1.000 15.74813 ? 39  SER A OG  1 
ATOM   152  N N   . GLN A 1 29  ? 14.17122  -29.32869 19.06663  1.000 9.81755  ? 40  GLN A N   1 
ATOM   153  C CA  . GLN A 1 29  ? 15.00244  -28.12996 19.07335  1.000 9.51383  ? 40  GLN A CA  1 
ATOM   154  C C   . GLN A 1 29  ? 15.40071  -27.74617 17.65710  1.000 8.43067  ? 40  GLN A C   1 
ATOM   155  O O   . GLN A 1 29  ? 15.35567  -26.56504 17.28674  1.000 8.00606  ? 40  GLN A O   1 
ATOM   156  C CB  . GLN A 1 29  ? 16.28169  -28.37252 19.87012  1.000 10.19767 ? 40  GLN A CB  1 
ATOM   157  C CG  . GLN A 1 29  ? 16.10568  -28.38591 21.36758  1.000 12.64034 ? 40  GLN A CG  1 
ATOM   158  C CD  . GLN A 1 29  ? 17.44526  -28.50933 22.06563  1.000 14.93051 ? 40  GLN A CD  1 
ATOM   159  O OE1 . GLN A 1 29  ? 18.28590  -29.32193 21.66859  1.000 21.54046 ? 40  GLN A OE1 1 
ATOM   160  N NE2 . GLN A 1 29  ? 17.64573  -27.72421 23.11904  1.000 17.75645 ? 40  GLN A NE2 1 
ATOM   161  N N   . GLN A 1 30  ? 15.79791  -28.73320 16.85096  1.000 8.08938  ? 41  GLN A N   1 
ATOM   162  C CA  . GLN A 1 30  ? 16.25814  -28.44592 15.49433  1.000 7.01283  ? 41  GLN A CA  1 
ATOM   163  C C   . GLN A 1 30  ? 15.12637  -27.88915 14.64759  1.000 5.89688  ? 41  GLN A C   1 
ATOM   164  O O   . GLN A 1 30  ? 15.32761  -26.94374 13.87137  1.000 7.07261  ? 41  GLN A O   1 
ATOM   165  C CB  . GLN A 1 30  ? 16.85027  -29.70898 14.86678  1.000 8.41097  ? 41  GLN A CB  1 
ATOM   166  C CG  . GLN A 1 30  ? 18.25380  -29.99130 15.39282  1.000 8.82893  ? 41  GLN A CG  1 
ATOM   167  C CD  . GLN A 1 30  ? 18.94524  -31.11883 14.64369  1.000 16.89144 ? 41  GLN A CD  1 
ATOM   168  O OE1 . GLN A 1 30  ? 18.33895  -31.79382 13.81520  1.000 22.48149 ? 41  GLN A OE1 1 
ATOM   169  N NE2 . GLN A 1 30  ? 20.22722  -31.31278 14.92426  1.000 27.71985 ? 41  GLN A NE2 1 
ATOM   170  N N   . GLU A 1 31  ? 13.92436  -28.43462 14.80564  1.000 8.12844  ? 42  GLU A N   1 
ATOM   171  C CA  . GLU A 1 31  ? 12.77168  -27.94313 14.06204  1.000 8.84195  ? 42  GLU A CA  1 
ATOM   172  C C   . GLU A 1 31  ? 12.43050  -26.51532 14.47589  1.000 6.90658  ? 42  GLU A C   1 
ATOM   173  O O   . GLU A 1 31  ? 12.13981  -25.66514 13.62781  1.000 7.67359  ? 42  GLU A O   1 
ATOM   174  C CB  . GLU A 1 31  ? 11.58211  -28.88130 14.28926  1.000 11.49776 ? 42  GLU A CB  1 
ATOM   175  C CG  . GLU A 1 31  ? 10.29636  -28.44290 13.61818  1.000 16.59108 ? 42  GLU A CG  1 
ATOM   176  C CD  . GLU A 1 31  ? 9.09377   -29.26756 14.05043  1.000 29.40814 ? 42  GLU A CD  1 
ATOM   177  O OE1 . GLU A 1 31  ? 9.28180   -30.35802 14.64843  1.000 27.64955 ? 42  GLU A OE1 1 
ATOM   178  O OE2 . GLU A 1 31  ? 7.95648   -28.81349 13.79753  1.000 29.10313 ? 42  GLU A OE2 1 
ATOM   179  N N   . MET A 1 32  ? 12.50193  -26.22603 15.77373  1.000 7.27326  ? 43  MET A N   1 
ATOM   180  C CA  . MET A 1 32  ? 12.23404  -24.88089 16.26330  1.000 6.73271  ? 43  MET A CA  1 
ATOM   181  C C   . MET A 1 32  ? 13.28203  -23.87942 15.77236  1.000 5.67892  ? 43  MET A C   1 
ATOM   182  O O   . MET A 1 32  ? 12.93688  -22.75231 15.37917  1.000 6.74120  ? 43  MET A O   1 
ATOM   183  C CB  . MET A 1 32  ? 12.16796  -24.94927 17.78676  1.000 11.13059 ? 43  MET A CB  1 
ATOM   184  C CG  . MET A 1 32  ? 11.69559  -23.72979 18.45787  1.000 10.17781 ? 43  MET A CG  1 
ATOM   185  S SD  . MET A 1 32  ? 11.26748  -24.13703 20.17192  1.000 10.40150 ? 43  MET A SD  1 
ATOM   186  C CE  . MET A 1 32  ? 10.16341  -22.77086 20.46139  1.000 11.09138 ? 43  MET A CE  1 
ATOM   187  N N   . GLN A 1 33  ? 14.55798  -24.26996 15.75468  1.000 6.92658  ? 44  GLN A N   1 
ATOM   188  C CA  . GLN A 1 33  ? 15.59762  -23.37299 15.25596  1.000 6.66346  ? 44  GLN A CA  1 
ATOM   189  C C   . GLN A 1 33  ? 15.35033  -23.00240 13.79436  1.000 8.61159  ? 44  GLN A C   1 
ATOM   190  O O   . GLN A 1 33  ? 15.39286  -21.81780 13.41962  1.000 8.35953  ? 44  GLN A O   1 
ATOM   191  C CB  . GLN A 1 33  ? 16.98015  -23.99935 15.45824  1.000 9.07431  ? 44  GLN A CB  1 
ATOM   192  C CG  . GLN A 1 33  ? 18.13197  -23.06699 15.07723  1.000 8.96365  ? 44  GLN A CG  1 
ATOM   193  C CD  . GLN A 1 33  ? 19.49654  -23.63613 15.40213  1.000 12.84886 ? 44  GLN A CD  1 
ATOM   194  O OE1 . GLN A 1 33  ? 19.60854  -24.65532 16.07705  1.000 21.01605 ? 44  GLN A OE1 1 
ATOM   195  N NE2 . GLN A 1 33  ? 20.54228  -22.99427 14.90312  1.000 18.35461 ? 44  GLN A NE2 1 
ATOM   196  N N   . LEU A 1 34  ? 15.05929  -24.00092 12.95433  1.000 6.78751  ? 45  LEU A N   1 
ATOM   197  C CA  . LEU A 1 34  ? 14.81066  -23.71572 11.54280  1.000 7.01812  ? 45  LEU A CA  1 
ATOM   198  C C   . LEU A 1 34  ? 13.55153  -22.87810 11.35198  1.000 6.40770  ? 45  LEU A C   1 
ATOM   199  O O   . LEU A 1 34  ? 13.51856  -21.98128 10.49136  1.000 6.57102  ? 45  LEU A O   1 
ATOM   200  C CB  . LEU A 1 34  ? 14.72037  -25.02192 10.74542  1.000 8.14269  ? 45  LEU A CB  1 
ATOM   201  C CG  . LEU A 1 34  ? 16.06157  -25.59060 10.26486  1.000 11.94684 ? 45  LEU A CG  1 
ATOM   202  C CD1 . LEU A 1 34  ? 15.83825  -26.94794 9.59673   1.000 13.61798 ? 45  LEU A CD1 1 
ATOM   203  C CD2 . LEU A 1 34  ? 16.76519  -24.62991 9.30859   1.000 10.03888 ? 45  LEU A CD2 1 
ATOM   204  N N   . LYS A 1 35  ? 12.50944  -23.14025 12.14722  1.000 7.48146  ? 46  LYS A N   1 
ATOM   205  C CA  . LYS A 1 35  ? 11.27169  -22.36824 12.02795  1.000 6.06664  ? 46  LYS A CA  1 
ATOM   206  C C   . LYS A 1 35  ? 11.49445  -20.90918 12.41079  1.000 6.75485  ? 46  LYS A C   1 
ATOM   207  O O   . LYS A 1 35  ? 10.94491  -19.99492 11.77422  1.000 8.05871  ? 46  LYS A O   1 
ATOM   208  C CB  . LYS A 1 35  ? 10.18120  -22.97733 12.91511  1.000 10.45190 ? 46  LYS A CB  1 
ATOM   209  C CG  . LYS A 1 35  ? 8.81126   -22.35220 12.70112  1.000 15.39749 ? 46  LYS A CG  1 
ATOM   210  C CD  . LYS A 1 35  ? 7.99476   -23.12786 11.67499  1.000 20.97182 ? 46  LYS A CD  1 
ATOM   211  C CE  . LYS A 1 35  ? 6.60247   -22.53289 11.51067  1.000 24.56394 ? 46  LYS A CE  1 
ATOM   212  N NZ  . LYS A 1 35  ? 5.67999   -23.48339 10.82459  1.000 34.36011 ? 46  LYS A NZ  1 
ATOM   213  N N   . CYS A 1 36  ? 12.30796  -20.67021 13.44006  1.000 6.57171  ? 47  CYS A N   1 
ATOM   214  C CA  . CYS A 1 36  ? 12.66709  -19.30334 13.78639  1.000 7.12542  ? 47  CYS A CA  1 
ATOM   215  C C   . CYS A 1 36  ? 13.32572  -18.60717 12.60096  1.000 8.35072  ? 47  CYS A C   1 
ATOM   216  O O   . CYS A 1 36  ? 12.97356  -17.47331 12.24916  1.000 8.70796  ? 47  CYS A O   1 
ATOM   217  C CB  . CYS A 1 36  ? 13.61886  -19.32773 14.98284  1.000 6.66263  ? 47  CYS A CB  1 
ATOM   218  S SG  . CYS A 1 36  ? 14.05673  -17.68044 15.54153  1.000 10.93740 ? 47  CYS A SG  1 
ATOM   219  N N   . VAL A 1 37  ? 14.29671  -19.27915 11.97196  1.000 6.96406  ? 48  VAL A N   1 
ATOM   220  C CA  . VAL A 1 37  ? 15.02675  -18.66929 10.86050  1.000 7.71910  ? 48  VAL A CA  1 
ATOM   221  C C   . VAL A 1 37  ? 14.10837  -18.42067 9.66566   1.000 9.34783  ? 48  VAL A C   1 
ATOM   222  O O   . VAL A 1 37  ? 14.15947  -17.35011 9.03988   1.000 7.71117  ? 48  VAL A O   1 
ATOM   223  C CB  . VAL A 1 37  ? 16.24608  -19.53536 10.49197  1.000 7.36934  ? 48  VAL A CB  1 
ATOM   224  C CG1 . VAL A 1 37  ? 16.93526  -18.98075 9.24047   1.000 8.56599  ? 48  VAL A CG1 1 
ATOM   225  C CG2 . VAL A 1 37  ? 17.20894  -19.61473 11.65643  1.000 7.73960  ? 48  VAL A CG2 1 
ATOM   226  N N   . SER A 1 38  ? 13.24978  -19.38919 9.32243   1.000 7.17586  ? 49  SER A N   1 
ATOM   227  C CA  A SER A 1 38  ? 12.39253  -19.19455 8.15508   0.750 7.90007  ? 49  SER A CA  1 
ATOM   228  C CA  B SER A 1 38  ? 12.37906  -19.21137 8.16168   0.250 7.92991  ? 49  SER A CA  1 
ATOM   229  C C   . SER A 1 38  ? 11.32314  -18.13488 8.40047   1.000 9.83292  ? 49  SER A C   1 
ATOM   230  O O   . SER A 1 38  ? 11.02634  -17.33456 7.50266   1.000 8.63407  ? 49  SER A O   1 
ATOM   231  C CB  A SER A 1 38  ? 11.78598  -20.51518 7.67222   0.750 7.67227  ? 49  SER A CB  1 
ATOM   232  C CB  B SER A 1 38  ? 11.72102  -20.53647 7.78763   0.250 7.81850  ? 49  SER A CB  1 
ATOM   233  O OG  A SER A 1 38  ? 11.00649  -21.13614 8.67678   0.750 8.48127  ? 49  SER A OG  1 
ATOM   234  O OG  B SER A 1 38  ? 10.48720  -20.30836 7.13709   0.250 10.84632 ? 49  SER A OG  1 
ATOM   235  N N   . GLN A 1 39  ? 10.73121  -18.10323 9.60075   1.000 8.01484  ? 50  GLN A N   1 
ATOM   236  C CA  . GLN A 1 39  ? 9.72928   -17.07912 9.87663   1.000 8.92210  ? 50  GLN A CA  1 
ATOM   237  C C   . GLN A 1 39  ? 10.35415  -15.69462 9.91142   1.000 9.55657  ? 50  GLN A C   1 
ATOM   238  O O   . GLN A 1 39  ? 9.71990   -14.71492 9.49583   1.000 11.27235 ? 50  GLN A O   1 
ATOM   239  C CB  . GLN A 1 39  ? 8.97328   -17.40065 11.17397  1.000 8.54037  ? 50  GLN A CB  1 
ATOM   240  C CG  . GLN A 1 39  ? 8.03947   -18.59801 11.01969  1.000 16.58603 ? 50  GLN A CG  1 
ATOM   241  C CD  . GLN A 1 39  ? 7.09165   -18.39551 9.85746   1.000 27.38789 ? 50  GLN A CD  1 
ATOM   242  O OE1 . GLN A 1 39  ? 6.56224   -17.30042 9.67612   1.000 33.77155 ? 50  GLN A OE1 1 
ATOM   243  N NE2 . GLN A 1 39  ? 6.86830   -19.44151 9.06707   1.000 29.41392 ? 50  GLN A NE2 1 
ATOM   244  N N   . SER A 1 40  ? 11.61078  -15.60485 10.35040  1.000 7.55468  ? 51  SER A N   1 
ATOM   245  C CA  . SER A 1 40  ? 12.31628  -14.33215 10.31076  1.000 6.85285  ? 51  SER A CA  1 
ATOM   246  C C   . SER A 1 40  ? 12.55913  -13.89916 8.87422   1.000 8.33643  ? 51  SER A C   1 
ATOM   247  O O   . SER A 1 40  ? 12.46862  -12.70374 8.55777   1.000 11.53805 ? 51  SER A O   1 
ATOM   248  C CB  . SER A 1 40  ? 13.63391  -14.46575 11.07056  1.000 9.85925  ? 51  SER A CB  1 
ATOM   249  O OG  . SER A 1 40  ? 13.39080  -14.71950 12.44704  1.000 10.47739 ? 51  SER A OG  1 
ATOM   250  N N   . ASP A 1 41  ? 12.87123  -14.86041 8.00038   1.000 7.82621  ? 52  ASP A N   1 
ATOM   251  C CA  . ASP A 1 41  ? 13.05218  -14.55653 6.58419   1.000 10.02370 ? 52  ASP A CA  1 
ATOM   252  C C   . ASP A 1 41  ? 11.76390  -14.00338 5.98610   1.000 9.95694  ? 52  ASP A C   1 
ATOM   253  O O   . ASP A 1 41  ? 11.79658  -13.02454 5.22488   1.000 13.72966 ? 52  ASP A O   1 
ATOM   254  C CB  . ASP A 1 41  ? 13.50464  -15.83179 5.86332   1.000 10.11769 ? 52  ASP A CB  1 
ATOM   255  C CG  . ASP A 1 41  ? 13.47810  -15.70083 4.35387   1.000 19.10568 ? 52  ASP A CG  1 
ATOM   256  O OD1 . ASP A 1 41  ? 14.21578  -14.83910 3.82032   1.000 19.61249 ? 52  ASP A OD1 1 
ATOM   257  O OD2 . ASP A 1 41  ? 12.73880  -16.48182 3.71129   1.000 22.37707 ? 52  ASP A OD2 1 
ATOM   258  N N   . GLU A 1 42  ? 10.62128  -14.59513 6.33636   1.000 10.54532 ? 53  GLU A N   1 
ATOM   259  C CA  . GLU A 1 42  ? 9.33240   -14.10703 5.85044   1.000 13.85847 ? 53  GLU A CA  1 
ATOM   260  C C   . GLU A 1 42  ? 9.05120   -12.69012 6.33994   1.000 15.96651 ? 53  GLU A C   1 
ATOM   261  O O   . GLU A 1 42  ? 8.62780   -11.82539 5.56152   1.000 16.65614 ? 53  GLU A O   1 
ATOM   262  C CB  . GLU A 1 42  ? 8.21260   -15.03999 6.29894   1.000 16.53859 ? 53  GLU A CB  1 
ATOM   263  C CG  . GLU A 1 42  ? 8.16324   -16.36565 5.54435   1.000 25.45495 ? 53  GLU A CG  1 
ATOM   264  C CD  . GLU A 1 42  ? 7.77562   -16.19506 4.07644   1.000 43.17940 ? 53  GLU A CD  1 
ATOM   265  O OE1 . GLU A 1 42  ? 8.09776   -17.09013 3.26095   1.000 36.60789 ? 53  GLU A OE1 1 
ATOM   266  O OE2 . GLU A 1 42  ? 7.14394   -15.16869 3.74020   1.000 33.39917 ? 53  GLU A OE2 1 
ATOM   267  N N   . LEU A 1 43  ? 9.25459   -12.44488 7.63931   1.000 12.54133 ? 54  LEU A N   1 
ATOM   268  C CA  . LEU A 1 43  ? 9.01975   -11.11521 8.19428   1.000 13.58061 ? 54  LEU A CA  1 
ATOM   269  C C   . LEU A 1 43  ? 9.95071   -10.08879 7.56811   1.000 13.77638 ? 54  LEU A C   1 
ATOM   270  O O   . LEU A 1 43  ? 9.54941   -8.94166  7.33518   1.000 19.21567 ? 54  LEU A O   1 
ATOM   271  C CB  . LEU A 1 43  ? 9.21017   -11.14961 9.71559   1.000 12.11133 ? 54  LEU A CB  1 
ATOM   272  C CG  . LEU A 1 43  ? 8.14549   -11.89747 10.50571  1.000 12.60350 ? 54  LEU A CG  1 
ATOM   273  C CD1 . LEU A 1 43  ? 8.67710   -12.24275 11.90590  1.000 13.93077 ? 54  LEU A CD1 1 
ATOM   274  C CD2 . LEU A 1 43  ? 6.84288   -11.09324 10.60916  1.000 16.66755 ? 54  LEU A CD2 1 
ATOM   275  N N   . ASP A 1 44  ? 11.20359  -10.47368 7.30940   1.000 11.49352 ? 55  ASP A N   1 
ATOM   276  C CA  . ASP A 1 44  ? 12.17842  -9.57403  6.70631   1.000 13.06045 ? 55  ASP A CA  1 
ATOM   277  C C   . ASP A 1 44  ? 11.79266  -9.14269  5.29182   1.000 18.02214 ? 55  ASP A C   1 
ATOM   278  O O   . ASP A 1 44  ? 12.29966  -8.11102  4.83191   1.000 14.69485 ? 55  ASP A O   1 
ATOM   279  C CB  . ASP A 1 44  ? 13.56324  -10.23582 6.63517   1.000 16.14825 ? 55  ASP A CB  1 
ATOM   280  C CG  . ASP A 1 44  ? 14.36238  -10.11862 7.93248   1.000 19.18585 ? 55  ASP A CG  1 
ATOM   281  O OD1 . ASP A 1 44  ? 13.95223  -9.35775  8.83614   1.000 17.33118 ? 55  ASP A OD1 1 
ATOM   282  O OD2 . ASP A 1 44  ? 15.42245  -10.78459 8.04221   1.000 20.63750 ? 55  ASP A OD2 1 
ATOM   283  N N   . THR A 1 45  ? 10.90932  -9.89191  4.60643   1.000 17.16899 ? 56  THR A N   1 
ATOM   284  C CA  . THR A 1 45  ? 10.64512  -9.68154  3.17835   1.000 20.34837 ? 56  THR A CA  1 
ATOM   285  C C   . THR A 1 45  ? 10.32827  -8.22940  2.86579   1.000 15.99030 ? 56  THR A C   1 
ATOM   286  O O   . THR A 1 45  ? 11.03332  -7.58191  2.08172   1.000 11.21690 ? 56  THR A O   1 
ATOM   287  C CB  . THR A 1 45  ? 9.48478   -10.55754 2.68636   1.000 19.09124 ? 56  THR A CB  1 
ATOM   288  O OG1 . THR A 1 45  ? 9.76702   -11.93812 2.93429   1.000 18.75278 ? 56  THR A OG1 1 
ATOM   289  C CG2 . THR A 1 45  ? 9.26718   -10.37015 1.17054   1.000 17.83715 ? 56  THR A CG2 1 
ATOM   290  N N   . MET A 1 46  ? 9.24298   -7.70717  3.44913   1.000 13.33820 ? 57  MET A N   1 
ATOM   291  C CA  . MET A 1 46  ? 8.84681   -6.33842  3.12648   1.000 14.97460 ? 57  MET A CA  1 
ATOM   292  C C   . MET A 1 46  ? 9.82316   -5.31893  3.68730   1.000 8.61006  ? 57  MET A C   1 
ATOM   293  O O   . MET A 1 46  ? 9.98602   -4.23387  3.09797   1.000 13.97170 ? 57  MET A O   1 
ATOM   294  C CB  . MET A 1 46  ? 7.43159   -6.06679  3.62492   1.000 18.24641 ? 57  MET A CB  1 
ATOM   295  C CG  . MET A 1 46  ? 6.38246   -6.57044  2.65213   1.000 17.75139 ? 57  MET A CG  1 
ATOM   296  S SD  . MET A 1 46  ? 4.70583   -6.23181  3.19818   1.000 22.85273 ? 57  MET A SD  1 
ATOM   297  C CE  . MET A 1 46  ? 3.78474   -6.96583  1.85053   1.000 21.54994 ? 57  MET A CE  1 
ATOM   298  N N   . MET A 1 47  ? 10.51536  -5.65175  4.79274   1.000 11.39432 ? 58  MET A N   1 
ATOM   299  C CA  . MET A 1 47  ? 11.51306  -4.71936  5.30885   1.000 9.87689  ? 58  MET A CA  1 
ATOM   300  C C   . MET A 1 47  ? 12.66123  -4.55225  4.32028   1.000 7.78973  ? 58  MET A C   1 
ATOM   301  O O   . MET A 1 47  ? 13.10668  -3.42571  4.06467   1.000 8.52036  ? 58  MET A O   1 
ATOM   302  C CB  . MET A 1 47  ? 12.07830  -5.09238  6.68631   1.000 10.01670 ? 58  MET A CB  1 
ATOM   303  C CG  . MET A 1 47  ? 11.11645  -5.06129  7.85409   1.000 14.19291 ? 58  MET A CG  1 
ATOM   304  S SD  . MET A 1 47  ? 11.82763  -5.96541  9.26053   1.000 13.23240 ? 58  MET A SD  1 
ATOM   305  C CE  . MET A 1 47  ? 10.40502  -6.13035  10.33771  1.000 19.50078 ? 58  MET A CE  1 
ATOM   306  N N   . GLN A 1 48  ? 13.15482  -5.66220  3.75892   1.000 9.18861  ? 59  GLN A N   1 
ATOM   307  C CA  . GLN A 1 48  ? 14.19571  -5.58212  2.73896   1.000 14.19270 ? 59  GLN A CA  1 
ATOM   308  C C   . GLN A 1 48  ? 13.69996  -4.88433  1.47467   1.000 9.75873  ? 59  GLN A C   1 
ATOM   309  O O   . GLN A 1 48  ? 14.44796  -4.12222  0.85712   1.000 11.15801 ? 59  GLN A O   1 
ATOM   310  C CB  . GLN A 1 48  ? 14.69923  -6.98577  2.40503   1.000 12.93056 ? 59  GLN A CB  1 
ATOM   311  C CG  . GLN A 1 48  ? 15.54125  -7.60220  3.50487   1.000 24.71560 ? 59  GLN A CG  1 
ATOM   312  C CD  . GLN A 1 48  ? 16.01827  -8.99430  3.14557   1.000 39.26932 ? 59  GLN A CD  1 
ATOM   313  O OE1 . GLN A 1 48  ? 15.54369  -9.98902  3.70178   1.000 31.58255 ? 59  GLN A OE1 1 
ATOM   314  N NE2 . GLN A 1 48  ? 16.95738  -9.07531  2.21044   1.000 48.48721 ? 59  GLN A NE2 1 
ATOM   315  N N   . ASN A 1 49  ? 12.44874  -5.12322  1.07776   1.000 8.08499  ? 60  ASN A N   1 
ATOM   316  C CA  . ASN A 1 49  ? 11.91601  -4.45463  -0.11094  1.000 9.74388  ? 60  ASN A CA  1 
ATOM   317  C C   . ASN A 1 49  ? 12.00120  -2.94457  0.05647   1.000 10.06339 ? 60  ASN A C   1 
ATOM   318  O O   . ASN A 1 49  ? 12.45464  -2.22106  -0.83964  1.000 11.78964 ? 60  ASN A O   1 
ATOM   319  C CB  . ASN A 1 49  ? 10.44971  -4.83092  -0.31809  1.000 11.69996 ? 60  ASN A CB  1 
ATOM   320  C CG  . ASN A 1 49  ? 10.25190  -6.27148  -0.77471  1.000 16.56883 ? 60  ASN A CG  1 
ATOM   321  O OD1 . ASN A 1 49  ? 11.18743  -6.94514  -1.21676  1.000 17.29860 ? 60  ASN A OD1 1 
ATOM   322  N ND2 . ASN A 1 49  ? 9.01136   -6.73884  -0.69241  1.000 19.18242 ? 60  ASN A ND2 1 
ATOM   323  N N   . VAL A 1 50  ? 11.57832  -2.45069  1.21763   1.000 7.01897  ? 61  VAL A N   1 
ATOM   324  C CA  . VAL A 1 50  ? 11.54471  -1.00593  1.44997   1.000 8.47389  ? 61  VAL A CA  1 
ATOM   325  C C   . VAL A 1 50  ? 12.95046  -0.44221  1.61255   1.000 11.58220 ? 61  VAL A C   1 
ATOM   326  O O   . VAL A 1 50  ? 13.28338  0.60840   1.04471   1.000 10.74257 ? 61  VAL A O   1 
ATOM   327  C CB  . VAL A 1 50  ? 10.66131  -0.69077  2.66854   1.000 8.10010  ? 61  VAL A CB  1 
ATOM   328  C CG1 . VAL A 1 50  ? 10.95951  0.70149   3.22044   1.000 10.92754 ? 61  VAL A CG1 1 
ATOM   329  C CG2 . VAL A 1 50  ? 9.19780   -0.82729  2.28431   1.000 13.57027 ? 61  VAL A CG2 1 
ATOM   330  N N   . SER A 1 51  ? 13.79596  -1.10876  2.40336   1.000 9.54068  ? 62  SER A N   1 
ATOM   331  C CA  A SER A 1 51  ? 15.13070  -0.56223  2.61344   0.551 9.70144  ? 62  SER A CA  1 
ATOM   332  C CA  B SER A 1 51  ? 15.16455  -0.63340  2.62541   0.449 9.73802  ? 62  SER A CA  1 
ATOM   333  C C   . SER A 1 51  ? 15.92509  -0.49519  1.30902   1.000 11.89745 ? 62  SER A C   1 
ATOM   334  O O   . SER A 1 51  ? 16.59785  0.51001   1.05625   1.000 11.28507 ? 62  SER A O   1 
ATOM   335  C CB  A SER A 1 51  ? 15.86499  -1.30207  3.73238   0.551 15.78964 ? 62  SER A CB  1 
ATOM   336  C CB  B SER A 1 51  ? 15.89340  -1.60787  3.55863   0.449 13.76384 ? 62  SER A CB  1 
ATOM   337  O OG  A SER A 1 51  ? 16.19052  -2.60593  3.33416   0.551 13.21770 ? 62  SER A OG  1 
ATOM   338  O OG  B SER A 1 51  ? 17.18781  -1.13627  3.88500   0.449 16.69387 ? 62  SER A OG  1 
ATOM   339  N N   . GLN A 1 52  ? 15.82360  -1.51630  0.45005   1.000 10.48330 ? 63  GLN A N   1 
ATOM   340  C CA  . GLN A 1 52  ? 16.51550  -1.48033  -0.83727  1.000 10.94651 ? 63  GLN A CA  1 
ATOM   341  C C   . GLN A 1 52  ? 16.01713  -0.33552  -1.71080  1.000 8.29827  ? 63  GLN A C   1 
ATOM   342  O O   . GLN A 1 52  ? 16.81607  0.34515   -2.36386  1.000 9.24398  ? 63  GLN A O   1 
ATOM   343  C CB  . GLN A 1 52  ? 16.36994  -2.81993  -1.56287  1.000 12.29763 ? 63  GLN A CB  1 
ATOM   344  C CG  . GLN A 1 52  ? 17.36805  -3.87334  -1.08329  1.000 24.41379 ? 63  GLN A CG  1 
ATOM   345  C CD  . GLN A 1 52  ? 16.89018  -5.28750  -1.32934  1.000 34.88024 ? 63  GLN A CD  1 
ATOM   346  O OE1 . GLN A 1 52  ? 16.18647  -5.55332  -2.30382  1.000 39.66524 ? 63  GLN A OE1 1 
ATOM   347  N NE2 . GLN A 1 52  ? 17.27415  -6.20747  -0.44628  1.000 33.91137 ? 63  GLN A NE2 1 
ATOM   348  N N   . SER A 1 53  ? 14.70143  -0.09362  -1.72927  1.000 7.54232  ? 64  SER A N   1 
ATOM   349  C CA  . SER A 1 53  ? 14.16731  0.99969   -2.53944  1.000 8.75787  ? 64  SER A CA  1 
ATOM   350  C C   . SER A 1 53  ? 14.58543  2.36290   -1.99628  1.000 7.49852  ? 64  SER A C   1 
ATOM   351  O O   . SER A 1 53  ? 14.95928  3.25324   -2.77003  1.000 7.37191  ? 64  SER A O   1 
ATOM   352  C CB  . SER A 1 53  ? 12.64723  0.90532   -2.62166  1.000 8.70360  ? 64  SER A CB  1 
ATOM   353  O OG  . SER A 1 53  ? 12.23944  -0.19763  -3.42312  1.000 10.23618 ? 64  SER A OG  1 
ATOM   354  N N   . VAL A 1 54  ? 14.50009  2.56045   -0.68130  1.000 7.81016  ? 65  VAL A N   1 
ATOM   355  C CA  . VAL A 1 54  ? 14.91354  3.83713   -0.09612  1.000 6.81907  ? 65  VAL A CA  1 
ATOM   356  C C   . VAL A 1 54  ? 16.39053  4.10053   -0.36148  1.000 8.26349  ? 65  VAL A C   1 
ATOM   357  O O   . VAL A 1 54  ? 16.77836  5.22891   -0.69775  1.000 9.12055  ? 65  VAL A O   1 
ATOM   358  C CB  . VAL A 1 54  ? 14.56478  3.86611   1.40805   1.000 6.55667  ? 65  VAL A CB  1 
ATOM   359  C CG1 . VAL A 1 54  ? 15.20189  5.07745   2.09440   1.000 9.99339  ? 65  VAL A CG1 1 
ATOM   360  C CG2 . VAL A 1 54  ? 13.02932  3.88749   1.61380   1.000 7.61167  ? 65  VAL A CG2 1 
ATOM   361  N N   . GLU A 1 55  ? 17.23363  3.06632   -0.23385  1.000 8.46832  ? 66  GLU A N   1 
ATOM   362  C CA  . GLU A 1 55  ? 18.66405  3.23073   -0.48699  1.000 9.44306  ? 66  GLU A CA  1 
ATOM   363  C C   . GLU A 1 55  ? 18.91750  3.62377   -1.93341  1.000 10.53245 ? 66  GLU A C   1 
ATOM   364  O O   . GLU A 1 55  ? 19.79514  4.45083   -2.21725  1.000 9.83241  ? 66  GLU A O   1 
ATOM   365  C CB  . GLU A 1 55  ? 19.40190  1.92884   -0.18987  1.000 9.38681  ? 66  GLU A CB  1 
ATOM   366  C CG  . GLU A 1 55  ? 19.41621  1.56524   1.26843   1.000 16.37472 ? 66  GLU A CG  1 
ATOM   367  C CD  . GLU A 1 55  ? 20.39217  2.36886   2.07266   1.000 24.41624 ? 66  GLU A CD  1 
ATOM   368  O OE1 . GLU A 1 55  ? 21.22058  3.09354   1.47687   1.000 21.19594 ? 66  GLU A OE1 1 
ATOM   369  O OE2 . GLU A 1 55  ? 20.33291  2.25867   3.31758   1.000 29.16888 ? 66  GLU A OE2 1 
ATOM   370  N N   . MET A 1 56  ? 18.15367  3.04381   -2.86203  1.000 7.64051  ? 67  MET A N   1 
ATOM   371  C CA  . MET A 1 56  ? 18.36183  3.34818   -4.27308  1.000 9.78362  ? 67  MET A CA  1 
ATOM   372  C C   . MET A 1 56  ? 17.96965  4.79054   -4.57625  1.000 8.43983  ? 67  MET A C   1 
ATOM   373  O O   . MET A 1 56  ? 18.71448  5.52008   -5.25148  1.000 11.73151 ? 67  MET A O   1 
ATOM   374  C CB  . MET A 1 56  ? 17.58408  2.34794   -5.12741  1.000 12.19859 ? 67  MET A CB  1 
ATOM   375  C CG  . MET A 1 56  ? 17.64318  2.55014   -6.61911  1.000 24.37316 ? 67  MET A CG  1 
ATOM   376  S SD  . MET A 1 56  ? 17.78233  0.94380   -7.45080  1.000 64.35447 ? 67  MET A SD  1 
ATOM   377  C CE  . MET A 1 56  ? 16.77078  -0.09290  -6.39292  1.000 19.67655 ? 67  MET A CE  1 
ATOM   378  N N   . VAL A 1 57  ? 16.82902  5.24706   -4.04874  1.000 7.29275  ? 68  VAL A N   1 
ATOM   379  C CA  . VAL A 1 57  ? 16.42944  6.62743   -4.30133  1.000 10.32152 ? 68  VAL A CA  1 
ATOM   380  C C   . VAL A 1 57  ? 17.37137  7.59384   -3.59525  1.000 7.54928  ? 68  VAL A C   1 
ATOM   381  O O   . VAL A 1 57  ? 17.70508  8.65698   -4.13868  1.000 9.46184  ? 68  VAL A O   1 
ATOM   382  C CB  . VAL A 1 57  ? 14.95429  6.86796   -3.92989  1.000 11.62727 ? 68  VAL A CB  1 
ATOM   383  C CG1 . VAL A 1 57  ? 14.54080  8.30198   -4.31966  1.000 15.43349 ? 68  VAL A CG1 1 
ATOM   384  C CG2 . VAL A 1 57  ? 14.06924  5.91817   -4.67214  1.000 14.95275 ? 68  VAL A CG2 1 
ATOM   385  N N   . TYR A 1 58  ? 17.80410  7.25202   -2.37498  1.000 7.55543  ? 69  TYR A N   1 
ATOM   386  C CA  . TYR A 1 58  ? 18.77251  8.08044   -1.65505  1.000 7.39166  ? 69  TYR A CA  1 
ATOM   387  C C   . TYR A 1 58  ? 20.01808  8.31822   -2.49996  1.000 9.71073  ? 69  TYR A C   1 
ATOM   388  O O   . TYR A 1 58  ? 20.51733  9.44451   -2.58764  1.000 8.53865  ? 69  TYR A O   1 
ATOM   389  C CB  . TYR A 1 58  ? 19.15057  7.41679   -0.32074  1.000 9.11355  ? 69  TYR A CB  1 
ATOM   390  C CG  . TYR A 1 58  ? 20.34950  8.07103   0.34518   1.000 7.62036  ? 69  TYR A CG  1 
ATOM   391  C CD1 . TYR A 1 58  ? 20.19535  9.16368   1.19083   1.000 9.08234  ? 69  TYR A CD1 1 
ATOM   392  C CD2 . TYR A 1 58  ? 21.64486  7.62492   0.09526   1.000 9.85351  ? 69  TYR A CD2 1 
ATOM   393  C CE1 . TYR A 1 58  ? 21.28744  9.77922   1.78621   1.000 9.95681  ? 69  TYR A CE1 1 
ATOM   394  C CE2 . TYR A 1 58  ? 22.73813  8.24106   0.67953   1.000 11.76464 ? 69  TYR A CE2 1 
ATOM   395  C CZ  . TYR A 1 58  ? 22.55503  9.31926   1.52313   1.000 10.04069 ? 69  TYR A CZ  1 
ATOM   396  O OH  . TYR A 1 58  ? 23.65387  9.92126   2.09335   1.000 13.02377 ? 69  TYR A OH  1 
ATOM   397  N N   . SER A 1 59  ? 20.55190  7.25740   -3.11621  1.000 9.48700  ? 70  SER A N   1 
ATOM   398  C CA  A SER A 1 59  ? 21.77673  7.40886   -3.89244  0.369 9.04664  ? 70  SER A CA  1 
ATOM   399  C CA  B SER A 1 59  ? 21.77758  7.40613   -3.89459  0.335 9.04950  ? 70  SER A CA  1 
ATOM   400  C CA  C SER A 1 59  ? 21.77732  7.40476   -3.89504  0.296 9.05932  ? 70  SER A CA  1 
ATOM   401  C C   . SER A 1 59  ? 21.58549  8.38538   -5.04625  1.000 10.86658 ? 70  SER A C   1 
ATOM   402  O O   . SER A 1 59  ? 22.46808  9.20427   -5.32724  1.000 10.74705 ? 70  SER A O   1 
ATOM   403  C CB  A SER A 1 59  ? 22.25824  6.04730   -4.38194  0.369 12.27016 ? 70  SER A CB  1 
ATOM   404  C CB  B SER A 1 59  ? 22.25587  6.04943   -4.40699  0.335 12.26843 ? 70  SER A CB  1 
ATOM   405  C CB  C SER A 1 59  ? 22.24074  6.04512   -4.41063  0.296 12.26155 ? 70  SER A CB  1 
ATOM   406  O OG  A SER A 1 59  ? 22.68517  5.26544   -3.28169  0.369 11.11106 ? 70  SER A OG  1 
ATOM   407  O OG  B SER A 1 59  ? 23.53873  6.16694   -5.00204  0.335 13.74603 ? 70  SER A OG  1 
ATOM   408  O OG  C SER A 1 59  ? 21.40135  5.59316   -5.45272  0.296 11.54777 ? 70  SER A OG  1 
ATOM   409  N N   . ILE A 1 60  ? 20.43125  8.32566   -5.71630  1.000 8.43309  ? 71  ILE A N   1 
ATOM   410  C CA  . ILE A 1 60  ? 20.14584  9.27492   -6.79580  1.000 7.80721  ? 71  ILE A CA  1 
ATOM   411  C C   . ILE A 1 60  ? 19.96584  10.68455  -6.23569  1.000 8.80670  ? 71  ILE A C   1 
ATOM   412  O O   . ILE A 1 60  ? 20.46509  11.67145  -6.80046  1.000 9.53088  ? 71  ILE A O   1 
ATOM   413  C CB  . ILE A 1 60  ? 18.90791  8.80747   -7.58018  1.000 10.81892 ? 71  ILE A CB  1 
ATOM   414  C CG1 . ILE A 1 60  ? 19.21296  7.49399   -8.30404  1.000 11.45792 ? 71  ILE A CG1 1 
ATOM   415  C CG2 . ILE A 1 60  ? 18.45721  9.86335   -8.58997  1.000 12.47699 ? 71  ILE A CG2 1 
ATOM   416  C CD1 . ILE A 1 60  ? 17.98648  6.77481   -8.76421  1.000 16.65687 ? 71  ILE A CD1 1 
ATOM   417  N N   . ALA A 1 61  ? 19.24486  10.79901  -5.12081  1.000 7.50755  ? 72  ALA A N   1 
ATOM   418  C CA  . ALA A 1 61  ? 18.96917  12.09265  -4.50276  1.000 6.73113  ? 72  ALA A CA  1 
ATOM   419  C C   . ALA A 1 61  ? 20.25520  12.84209  -4.15563  1.000 8.74226  ? 72  ALA A C   1 
ATOM   420  O O   . ALA A 1 61  ? 20.38675  14.04743  -4.43587  1.000 8.90404  ? 72  ALA A O   1 
ATOM   421  C CB  . ALA A 1 61  ? 18.09932  11.87366  -3.25165  1.000 8.74482  ? 72  ALA A CB  1 
ATOM   422  N N   . VAL A 1 62  ? 21.21125  12.16246  -3.52238  1.000 8.42663  ? 73  VAL A N   1 
ATOM   423  C CA  . VAL A 1 62  ? 22.41788  12.88117  -3.11340  1.000 9.20164  ? 73  VAL A CA  1 
ATOM   424  C C   . VAL A 1 62  ? 23.33542  13.16590  -4.30211  1.000 11.68419 ? 73  VAL A C   1 
ATOM   425  O O   . VAL A 1 62  ? 24.06185  14.17197  -4.29796  1.000 14.18832 ? 73  VAL A O   1 
ATOM   426  C CB  . VAL A 1 62  ? 23.14982  12.18910  -1.94656  1.000 13.33864 ? 73  VAL A CB  1 
ATOM   427  C CG1 . VAL A 1 62  ? 22.27411  12.17774  -0.68618  1.000 13.93326 ? 73  VAL A CG1 1 
ATOM   428  C CG2 . VAL A 1 62  ? 23.56071  10.78886  -2.33374  1.000 13.13363 ? 73  VAL A CG2 1 
ATOM   429  N N   . ALA A 1 63  ? 23.31005  12.32384  -5.33537  1.000 10.51818 ? 74  ALA A N   1 
ATOM   430  C CA  . ALA A 1 63  ? 24.09433  12.62212  -6.53094  1.000 10.97273 ? 74  ALA A CA  1 
ATOM   431  C C   . ALA A 1 63  ? 23.55707  13.85865  -7.23810  1.000 14.81214 ? 74  ALA A C   1 
ATOM   432  O O   . ALA A 1 63  ? 24.33638  14.66967  -7.75534  1.000 13.97111 ? 74  ALA A O   1 
ATOM   433  C CB  . ALA A 1 63  ? 24.10525  11.42754  -7.47545  1.000 12.18355 ? 74  ALA A CB  1 
ATOM   434  N N   . LYS A 1 64  ? 22.23249  14.02380  -7.26094  1.000 8.92706  ? 75  LYS A N   1 
ATOM   435  C CA  . LYS A 1 64  ? 21.61289  15.18857  -7.89300  1.000 9.30336  ? 75  LYS A CA  1 
ATOM   436  C C   . LYS A 1 64  ? 21.74635  16.46921  -7.07178  1.000 9.48170  ? 75  LYS A C   1 
ATOM   437  O O   . LYS A 1 64  ? 21.67219  17.56603  -7.63917  1.000 11.82630 ? 75  LYS A O   1 
ATOM   438  C CB  . LYS A 1 64  ? 20.12519  14.93713  -8.14363  1.000 12.00356 ? 75  LYS A CB  1 
ATOM   439  C CG  . LYS A 1 64  ? 19.78967  14.13583  -9.39342  1.000 17.11189 ? 75  LYS A CG  1 
ATOM   440  C CD  . LYS A 1 64  ? 18.32666  14.40469  -9.79904  1.000 22.76964 ? 75  LYS A CD  1 
ATOM   441  C CE  . LYS A 1 64  ? 17.86965  13.46898  -10.89785 1.000 28.78254 ? 75  LYS A CE  1 
ATOM   442  N NZ  . LYS A 1 64  ? 18.38843  13.89764  -12.22438 1.000 31.92356 ? 75  LYS A NZ  1 
ATOM   443  N N   . LEU A 1 65  ? 21.93050  16.36036  -5.75602  1.000 9.05365  ? 76  LEU A N   1 
ATOM   444  C CA  . LEU A 1 65  ? 21.99900  17.51190  -4.85671  1.000 11.44877 ? 76  LEU A CA  1 
ATOM   445  C C   . LEU A 1 65  ? 23.41914  18.06687  -4.90290  1.000 14.48948 ? 76  LEU A C   1 
ATOM   446  O O   . LEU A 1 65  ? 24.22873  17.89729  -3.98688  1.000 17.14352 ? 76  LEU A O   1 
ATOM   447  C CB  . LEU A 1 65  ? 21.59029  17.08533  -3.44756  1.000 13.15737 ? 76  LEU A CB  1 
ATOM   448  C CG  . LEU A 1 65  ? 21.63795  18.09858  -2.30860  1.000 25.34689 ? 76  LEU A CG  1 
ATOM   449  C CD1 . LEU A 1 65  ? 20.74018  19.25268  -2.61911  1.000 18.01108 ? 76  LEU A CD1 1 
ATOM   450  C CD2 . LEU A 1 65  ? 21.20786  17.42707  -1.01062  1.000 23.58288 ? 76  LEU A CD2 1 
ATOM   451  N N   . GLU A 1 66  ? 23.71778  18.77160  -5.99642  1.000 12.18702 ? 77  GLU A N   1 
ATOM   452  C CA  . GLU A 1 66  ? 25.09381  19.14516  -6.29687  1.000 15.10561 ? 77  GLU A CA  1 
ATOM   453  C C   . GLU A 1 66  ? 25.55529  20.38574  -5.54456  1.000 16.06998 ? 77  GLU A C   1 
ATOM   454  O O   . GLU A 1 66  ? 26.76467  20.55712  -5.34130  1.000 21.33578 ? 77  GLU A O   1 
ATOM   455  C CB  . GLU A 1 66  ? 25.25887  19.32033  -7.81335  1.000 17.80118 ? 77  GLU A CB  1 
ATOM   456  C CG  . GLU A 1 66  ? 26.69626  19.58510  -8.30470  1.000 23.86399 ? 77  GLU A CG  1 
ATOM   457  C CD  . GLU A 1 66  ? 27.09750  21.05936  -8.32305  1.000 25.33637 ? 77  GLU A CD  1 
ATOM   458  O OE1 . GLU A 1 66  ? 26.21707  21.94392  -8.25089  1.000 22.21421 ? 77  GLU A OE1 1 
ATOM   459  O OE2 . GLU A 1 66  ? 28.31179  21.33708  -8.42973  1.000 29.14184 ? 77  GLU A OE2 1 
ATOM   460  N N   . HIS A 1 67  ? 24.63096  21.25130  -5.11824  1.000 11.82939 ? 78  HIS A N   1 
ATOM   461  C CA  . HIS A 1 67  ? 24.99825  22.50681  -4.45217  1.000 11.96977 ? 78  HIS A CA  1 
ATOM   462  C C   . HIS A 1 67  ? 24.01718  22.74952  -3.30634  1.000 13.63584 ? 78  HIS A C   1 
ATOM   463  O O   . HIS A 1 67  ? 23.06572  23.52829  -3.41336  1.000 12.59366 ? 78  HIS A O   1 
ATOM   464  C CB  . HIS A 1 67  ? 25.05892  23.66565  -5.43968  1.000 14.76719 ? 78  HIS A CB  1 
ATOM   465  C CG  . HIS A 1 67  ? 25.90225  24.80592  -4.96817  1.000 18.40985 ? 78  HIS A CG  1 
ATOM   466  N ND1 . HIS A 1 67  ? 25.37265  25.93016  -4.37239  1.000 24.65202 ? 78  HIS A ND1 1 
ATOM   467  C CD2 . HIS A 1 67  ? 27.24403  24.98688  -4.98891  1.000 21.94919 ? 78  HIS A CD2 1 
ATOM   468  C CE1 . HIS A 1 67  ? 26.35113  26.76057  -4.05915  1.000 24.41041 ? 78  HIS A CE1 1 
ATOM   469  N NE2 . HIS A 1 67  ? 27.49668  26.21190  -4.41983  1.000 28.08427 ? 78  HIS A NE2 1 
ATOM   470  N N   . ALA A 1 68  ? 24.27435  22.07200  -2.18374  1.000 15.74553 ? 79  ALA A N   1 
ATOM   471  C CA  . ALA A 1 68  ? 23.34436  22.08616  -1.06126  1.000 16.90244 ? 79  ALA A CA  1 
ATOM   472  C C   . ALA A 1 68  ? 23.18402  23.47346  -0.45411  1.000 11.38497 ? 79  ALA A C   1 
ATOM   473  O O   . ALA A 1 68  ? 22.13414  23.77406  0.12376   1.000 15.32169 ? 79  ALA A O   1 
ATOM   474  C CB  . ALA A 1 68  ? 23.80930  21.09269  0.00491   1.000 18.02798 ? 79  ALA A CB  1 
ATOM   475  N N   . ALA A 1 69  ? 24.19372  24.33647  -0.58960  1.000 14.05507 ? 80  ALA A N   1 
ATOM   476  C CA  . ALA A 1 69  ? 24.09630  25.68320  -0.04053  1.000 18.16317 ? 80  ALA A CA  1 
ATOM   477  C C   . ALA A 1 69  ? 22.90621  26.43418  -0.61773  1.000 17.46485 ? 80  ALA A C   1 
ATOM   478  O O   . ALA A 1 69  ? 22.32982  27.29994  0.04954   1.000 18.02941 ? 80  ALA A O   1 
ATOM   479  C CB  . ALA A 1 69  ? 25.39231  26.45184  -0.30712  1.000 24.36922 ? 80  ALA A CB  1 
ATOM   480  N N   . SER A 1 70  ? 22.51936  26.11275  -1.85441  1.000 14.23647 ? 81  SER A N   1 
ATOM   481  C CA  . SER A 1 70  ? 21.40564  26.80638  -2.48235  1.000 11.69371 ? 81  SER A CA  1 
ATOM   482  C C   . SER A 1 70  ? 20.05715  26.43585  -1.88347  1.000 12.20659 ? 81  SER A C   1 
ATOM   483  O O   . SER A 1 70  ? 19.08209  27.14465  -2.12900  1.000 14.03848 ? 81  SER A O   1 
ATOM   484  C CB  . SER A 1 70  ? 21.40006  26.55954  -3.99480  1.000 14.13627 ? 81  SER A CB  1 
ATOM   485  O OG  . SER A 1 70  ? 22.48076  27.22158  -4.60657  1.000 15.72646 ? 81  SER A OG  1 
ATOM   486  N N   . PHE A 1 71  ? 19.96541  25.34363  -1.11473  1.000 12.18854 ? 82  PHE A N   1 
ATOM   487  C CA  . PHE A 1 71  ? 18.70230  25.02934  -0.45010  1.000 12.54267 ? 82  PHE A CA  1 
ATOM   488  C C   . PHE A 1 71  ? 18.31757  26.09489  0.56699   1.000 15.36814 ? 82  PHE A C   1 
ATOM   489  O O   . PHE A 1 71  ? 17.13277  26.26715  0.86743   1.000 18.01132 ? 82  PHE A O   1 
ATOM   490  C CB  . PHE A 1 71  ? 18.79289  23.66404  0.23757   1.000 16.03108 ? 82  PHE A CB  1 
ATOM   491  C CG  . PHE A 1 71  ? 18.08407  22.56818  -0.50454  1.000 8.25398  ? 82  PHE A CG  1 
ATOM   492  C CD1 . PHE A 1 71  ? 18.51634  22.18707  -1.76192  1.000 13.21360 ? 82  PHE A CD1 1 
ATOM   493  C CD2 . PHE A 1 71  ? 16.98133  21.93914  0.03870   1.000 11.00089 ? 82  PHE A CD2 1 
ATOM   494  C CE1 . PHE A 1 71  ? 17.85283  21.20046  -2.46308  1.000 13.33972 ? 82  PHE A CE1 1 
ATOM   495  C CE2 . PHE A 1 71  ? 16.31834  20.94621  -0.65525  1.000 11.36051 ? 82  PHE A CE2 1 
ATOM   496  C CZ  . PHE A 1 71  ? 16.76240  20.56841  -1.90225  1.000 11.46666 ? 82  PHE A CZ  1 
ATOM   497  N N   . ARG A 1 72  ? 19.29843  26.81999  1.10956   1.000 13.34445 ? 83  ARG A N   1 
ATOM   498  C CA  . ARG A 1 72  ? 19.02115  27.81484  2.13862   1.000 15.58282 ? 83  ARG A CA  1 
ATOM   499  C C   . ARG A 1 72  ? 18.55666  29.14131  1.56215   1.000 20.41740 ? 83  ARG A C   1 
ATOM   500  O O   . ARG A 1 72  ? 17.89934  29.91309  2.26959   1.000 19.40836 ? 83  ARG A O   1 
ATOM   501  C CB  . ARG A 1 72  ? 20.28435  28.03188  2.97986   1.000 17.59943 ? 83  ARG A CB  1 
ATOM   502  C CG  . ARG A 1 72  ? 20.81318  26.74858  3.60260   1.000 19.90529 ? 83  ARG A CG  1 
ATOM   503  C CD  . ARG A 1 72  ? 22.16762  26.94058  4.30219   1.000 22.04955 ? 83  ARG A CD  1 
ATOM   504  N NE  . ARG A 1 72  ? 22.74433  25.66118  4.70254   1.000 22.89447 ? 83  ARG A NE  1 
ATOM   505  C CZ  . ARG A 1 72  ? 22.38106  24.96095  5.77235   1.000 22.92883 ? 83  ARG A CZ  1 
ATOM   506  N NH1 . ARG A 1 72  ? 21.52759  25.44460  6.66183   1.000 22.74192 ? 83  ARG A NH1 1 
ATOM   507  N NH2 . ARG A 1 72  ? 22.90507  23.75500  5.96455   1.000 22.20023 ? 83  ARG A NH2 1 
ATOM   508  N N   . THR A 1 73  ? 18.86049  29.41853  0.28890   1.000 15.20484 ? 84  THR A N   1 
ATOM   509  C CA  . THR A 1 73  ? 18.65135  30.74753  -0.26566  1.000 16.28393 ? 84  THR A CA  1 
ATOM   510  C C   . THR A 1 73  ? 17.88430  30.78348  -1.57857  1.000 16.68136 ? 84  THR A C   1 
ATOM   511  O O   . THR A 1 73  ? 17.56416  31.88598  -2.04420  1.000 17.16760 ? 84  THR A O   1 
ATOM   512  C CB  . THR A 1 73  ? 19.99792  31.45613  -0.47398  1.000 17.86115 ? 84  THR A CB  1 
ATOM   513  O OG1 . THR A 1 73  ? 20.92999  30.54903  -1.08947  1.000 18.23730 ? 84  THR A OG1 1 
ATOM   514  C CG2 . THR A 1 73  ? 20.56067  31.92825  0.85988   1.000 26.24882 ? 84  THR A CG2 1 
ATOM   515  N N   . SER A 1 74  ? 17.58819  29.63890  -2.19945  1.000 12.75933 ? 85  SER A N   1 
ATOM   516  C CA  . SER A 1 74  ? 16.92569  29.63009  -3.50388  1.000 11.47069 ? 85  SER A CA  1 
ATOM   517  C C   . SER A 1 74  ? 15.72157  28.69527  -3.49813  1.000 12.49191 ? 85  SER A C   1 
ATOM   518  O O   . SER A 1 74  ? 15.87319  27.47658  -3.62118  1.000 10.73711 ? 85  SER A O   1 
ATOM   519  C CB  . SER A 1 74  ? 17.89588  29.24192  -4.61988  1.000 11.33303 ? 85  SER A CB  1 
ATOM   520  O OG  . SER A 1 74  ? 17.22069  29.19396  -5.86754  1.000 12.55773 ? 85  SER A OG  1 
ATOM   521  N N   . LYS A 1 75  ? 14.52380  29.27796  -3.44219  1.000 10.39257 ? 86  LYS A N   1 
ATOM   522  C CA  . LYS A 1 75  ? 13.31211  28.49164  -3.62287  1.000 10.68976 ? 86  LYS A CA  1 
ATOM   523  C C   . LYS A 1 75  ? 13.26848  27.85411  -5.00939  1.000 11.68363 ? 86  LYS A C   1 
ATOM   524  O O   . LYS A 1 75  ? 12.78036  26.73079  -5.16174  1.000 9.84835  ? 86  LYS A O   1 
ATOM   525  C CB  . LYS A 1 75  ? 12.08591  29.36045  -3.34490  1.000 15.41350 ? 86  LYS A CB  1 
ATOM   526  C CG  . LYS A 1 75  ? 10.76594  28.64331  -3.48925  1.000 17.45502 ? 86  LYS A CG  1 
ATOM   527  C CD  . LYS A 1 75  ? 9.59964   29.64074  -3.43074  1.000 24.45486 ? 86  LYS A CD  1 
ATOM   528  C CE  . LYS A 1 75  ? 8.31105   29.03768  -3.97460  1.000 25.04598 ? 86  LYS A CE  1 
ATOM   529  N NZ  . LYS A 1 75  ? 7.98580   27.76390  -3.27842  1.000 33.12570 ? 86  LYS A NZ  1 
ATOM   530  N N   . ASP A 1 76  ? 13.80105  28.53952  -6.02328  1.000 10.29703 ? 87  ASP A N   1 
ATOM   531  C CA  . ASP A 1 76  ? 13.88792  27.94129  -7.35487  1.000 8.19577  ? 87  ASP A CA  1 
ATOM   532  C C   . ASP A 1 76  ? 14.71883  26.65951  -7.33703  1.000 7.93441  ? 87  ASP A C   1 
ATOM   533  O O   . ASP A 1 76  ? 14.33293  25.65086  -7.93779  1.000 9.16296  ? 87  ASP A O   1 
ATOM   534  C CB  . ASP A 1 76  ? 14.47308  28.96445  -8.33272  1.000 8.59864  ? 87  ASP A CB  1 
ATOM   535  C CG  . ASP A 1 76  ? 14.36002  28.53869  -9.79894  1.000 10.98512 ? 87  ASP A CG  1 
ATOM   536  O OD1 . ASP A 1 76  ? 13.69971  27.52373  -10.12822 1.000 15.69649 ? 87  ASP A OD1 1 
ATOM   537  O OD2 . ASP A 1 76  ? 14.95038  29.25415  -10.64088 1.000 15.17807 ? 87  ASP A OD2 1 
ATOM   538  N N   . TYR A 1 77  ? 15.85318  26.66562  -6.63307  1.000 8.11926  ? 88  TYR A N   1 
ATOM   539  C CA  . TYR A 1 77  ? 16.65255  25.44132  -6.55179  1.000 7.08838  ? 88  TYR A CA  1 
ATOM   540  C C   . TYR A 1 77  ? 15.87292  24.31489  -5.87728  1.000 7.30337  ? 88  TYR A C   1 
ATOM   541  O O   . TYR A 1 77  ? 15.83088  23.18661  -6.38179  1.000 8.18668  ? 88  TYR A O   1 
ATOM   542  C CB  . TYR A 1 77  ? 17.95797  25.70208  -5.81104  1.000 6.87513  ? 88  TYR A CB  1 
ATOM   543  C CG  . TYR A 1 77  ? 18.99046  24.61789  -5.97282  1.000 8.25885  ? 88  TYR A CG  1 
ATOM   544  C CD1 . TYR A 1 77  ? 19.79699  24.57106  -7.10475  1.000 11.63071 ? 88  TYR A CD1 1 
ATOM   545  C CD2 . TYR A 1 77  ? 19.16263  23.62928  -5.00142  1.000 12.75539 ? 88  TYR A CD2 1 
ATOM   546  C CE1 . TYR A 1 77  ? 20.75195  23.57635  -7.27000  1.000 10.38214 ? 88  TYR A CE1 1 
ATOM   547  C CE2 . TYR A 1 77  ? 20.12816  22.61835  -5.17046  1.000 11.95081 ? 88  TYR A CE2 1 
ATOM   548  C CZ  . TYR A 1 77  ? 20.92594  22.62479  -6.31024  1.000 9.88608  ? 88  TYR A CZ  1 
ATOM   549  O OH  . TYR A 1 77  ? 21.88914  21.66049  -6.51684  1.000 12.15422 ? 88  TYR A OH  1 
ATOM   550  N N   . VAL A 1 78  ? 15.25204  24.60369  -4.73088  1.000 6.81772  ? 89  VAL A N   1 
ATOM   551  C CA  . VAL A 1 78  ? 14.48525  23.58201  -4.01506  1.000 8.29295  ? 89  VAL A CA  1 
ATOM   552  C C   . VAL A 1 78  ? 13.38030  23.02924  -4.90507  1.000 9.30493  ? 89  VAL A C   1 
ATOM   553  O O   . VAL A 1 78  ? 13.19119  21.81137  -4.99889  1.000 7.08629  ? 89  VAL A O   1 
ATOM   554  C CB  . VAL A 1 78  ? 13.90836  24.16099  -2.71004  1.000 7.94677  ? 89  VAL A CB  1 
ATOM   555  C CG1 . VAL A 1 78  ? 13.00499  23.12300  -2.00894  1.000 9.16084  ? 89  VAL A CG1 1 
ATOM   556  C CG2 . VAL A 1 78  ? 15.02982  24.62988  -1.79041  1.000 8.67076  ? 89  VAL A CG2 1 
ATOM   557  N N   . ASP A 1 79  ? 12.62548  23.91927  -5.55744  1.000 9.87817  ? 90  ASP A N   1 
ATOM   558  C CA  . ASP A 1 79  ? 11.48734  23.49113  -6.36201  1.000 11.50243 ? 90  ASP A CA  1 
ATOM   559  C C   . ASP A 1 79  ? 11.93883  22.71095  -7.59706  1.000 9.26210  ? 90  ASP A C   1 
ATOM   560  O O   . ASP A 1 79  ? 11.31121  21.71248  -7.96150  1.000 9.65245  ? 90  ASP A O   1 
ATOM   561  C CB  . ASP A 1 79  ? 10.61169  24.69571  -6.74056  1.000 11.62929 ? 90  ASP A CB  1 
ATOM   562  C CG  . ASP A 1 79  ? 9.82937   25.25649  -5.54265  1.000 17.93660 ? 90  ASP A CG  1 
ATOM   563  O OD1 . ASP A 1 79  ? 9.78603   24.59079  -4.48824  1.000 20.05333 ? 90  ASP A OD1 1 
ATOM   564  O OD2 . ASP A 1 79  ? 9.26052   26.36193  -5.66886  1.000 35.13018 ? 90  ASP A OD2 1 
ATOM   565  N N   . THR A 1 80  ? 13.04096  23.12811  -8.23231  1.000 7.02252  ? 91  THR A N   1 
ATOM   566  C CA  . THR A 1 80  ? 13.51204  22.41666  -9.41684  1.000 6.62763  ? 91  THR A CA  1 
ATOM   567  C C   . THR A 1 80  ? 14.02546  21.02937  -9.04585  1.000 6.59030  ? 91  THR A C   1 
ATOM   568  O O   . THR A 1 80  ? 13.72851  20.03590  -9.73343  1.000 7.67456  ? 91  THR A O   1 
ATOM   569  C CB  . THR A 1 80  ? 14.60299  23.23933  -10.09995 1.000 9.37998  ? 91  THR A CB  1 
ATOM   570  O OG1 . THR A 1 80  ? 14.08301  24.53547  -10.43820 1.000 10.26684 ? 91  THR A OG1 1 
ATOM   571  C CG2 . THR A 1 80  ? 15.13091  22.52306  -11.36627 1.000 7.85098  ? 91  THR A CG2 1 
ATOM   572  N N   . TYR A 1 81  ? 14.79494  20.95370  -7.95425  1.000 6.73397  ? 92  TYR A N   1 
ATOM   573  C CA  . TYR A 1 81  ? 15.27854  19.67307  -7.44086  1.000 7.35299  ? 92  TYR A CA  1 
ATOM   574  C C   . TYR A 1 81  ? 14.12185  18.72918  -7.12576  1.000 7.63924  ? 92  TYR A C   1 
ATOM   575  O O   . TYR A 1 81  ? 14.14982  17.54559  -7.50199  1.000 7.32335  ? 92  TYR A O   1 
ATOM   576  C CB  . TYR A 1 81  ? 16.14202  19.92905  -6.20370  1.000 6.79918  ? 92  TYR A CB  1 
ATOM   577  C CG  . TYR A 1 81  ? 16.63159  18.67301  -5.52279  1.000 8.42370  ? 92  TYR A CG  1 
ATOM   578  C CD1 . TYR A 1 81  ? 17.79271  18.03611  -5.95187  1.000 8.63257  ? 92  TYR A CD1 1 
ATOM   579  C CD2 . TYR A 1 81  ? 15.94402  18.12949  -4.45018  1.000 9.11964  ? 92  TYR A CD2 1 
ATOM   580  C CE1 . TYR A 1 81  ? 18.24426  16.86938  -5.32819  1.000 9.40168  ? 92  TYR A CE1 1 
ATOM   581  C CE2 . TYR A 1 81  ? 16.39245  16.97373  -3.82442  1.000 8.97608  ? 92  TYR A CE2 1 
ATOM   582  C CZ  . TYR A 1 81  ? 17.54064  16.35660  -4.26375  1.000 9.06491  ? 92  TYR A CZ  1 
ATOM   583  O OH  . TYR A 1 81  ? 17.97929  15.19595  -3.63814  1.000 9.85987  ? 92  TYR A OH  1 
ATOM   584  N N   . THR A 1 82  ? 13.08510  19.24654  -6.44313  1.000 7.95619  ? 93  THR A N   1 
ATOM   585  C CA  . THR A 1 82  ? 11.92819  18.43397  -6.07720  1.000 7.66764  ? 93  THR A CA  1 
ATOM   586  C C   . THR A 1 82  ? 11.21803  17.88111  -7.30835  1.000 6.26464  ? 93  THR A C   1 
ATOM   587  O O   . THR A 1 82  ? 10.84126  16.70299  -7.33710  1.000 6.92591  ? 93  THR A O   1 
ATOM   588  C CB  . THR A 1 82  ? 10.98322  19.28487  -5.23119  1.000 7.47359  ? 93  THR A CB  1 
ATOM   589  O OG1 . THR A 1 82  ? 11.66371  19.69709  -4.04295  1.000 9.01637  ? 93  THR A OG1 1 
ATOM   590  C CG2 . THR A 1 82  ? 9.76946   18.47097  -4.79589  1.000 10.23127 ? 93  THR A CG2 1 
ATOM   591  N N   . LYS A 1 83  ? 11.04052  18.72063  -8.33830  1.000 7.82623  ? 94  LYS A N   1 
ATOM   592  C CA  . LYS A 1 83  ? 10.35924  18.27424  -9.55276  1.000 8.93620  ? 94  LYS A CA  1 
ATOM   593  C C   . LYS A 1 83  ? 11.15977  17.19752  -10.27819 1.000 7.43907  ? 94  LYS A C   1 
ATOM   594  O O   . LYS A 1 83  ? 10.58126  16.24891  -10.82472 1.000 10.51849 ? 94  LYS A O   1 
ATOM   595  C CB  . LYS A 1 83  ? 10.07017  19.47041  -10.45536 1.000 12.52349 ? 94  LYS A CB  1 
ATOM   596  C CG  . LYS A 1 83  ? 8.86190   20.25857  -9.98907  1.000 23.44121 ? 94  LYS A CG  1 
ATOM   597  C CD  . LYS A 1 83  ? 9.00952   21.76227  -10.15184 1.000 35.23122 ? 94  LYS A CD  1 
ATOM   598  C CE  . LYS A 1 83  ? 8.17929   22.47993  -9.08041  1.000 37.65244 ? 94  LYS A CE  1 
ATOM   599  N NZ  . LYS A 1 83  ? 8.33156   21.81181  -7.72278  1.000 20.58886 ? 94  LYS A NZ  1 
ATOM   600  N N   . GLN A 1 84  ? 12.49672  17.30521  -10.26639 1.000 7.77832  ? 95  GLN A N   1 
ATOM   601  C CA  . GLN A 1 84  ? 13.31512  16.24046  -10.84671 1.000 7.99787  ? 95  GLN A CA  1 
ATOM   602  C C   . GLN A 1 84  ? 13.20577  14.94085  -10.05368 1.000 9.23785  ? 95  GLN A C   1 
ATOM   603  O O   . GLN A 1 84  ? 13.28646  13.85424  -10.63456 1.000 9.77887  ? 95  GLN A O   1 
ATOM   604  C CB  . GLN A 1 84  ? 14.77772  16.69214  -10.91954 1.000 7.47750  ? 95  GLN A CB  1 
ATOM   605  C CG  . GLN A 1 84  ? 15.01663  17.84299  -11.90408 1.000 8.11802  ? 95  GLN A CG  1 
ATOM   606  C CD  . GLN A 1 84  ? 16.48786  18.22193  -12.03263 1.000 9.36424  ? 95  GLN A CD  1 
ATOM   607  O OE1 . GLN A 1 84  ? 17.36142  17.55532  -11.49496 1.000 11.08342 ? 95  GLN A OE1 1 
ATOM   608  N NE2 . GLN A 1 84  ? 16.76292  19.28924  -12.79822 1.000 9.42353  ? 95  GLN A NE2 1 
ATOM   609  N N   . MET A 1 85  ? 13.05277  15.02394  -8.72607  1.000 8.06811  ? 96  MET A N   1 
ATOM   610  C CA  . MET A 1 85  ? 13.00300  13.80887  -7.91831  1.000 8.94482  ? 96  MET A CA  1 
ATOM   611  C C   . MET A 1 85  ? 11.64703  13.12553  -7.95524  1.000 8.19062  ? 96  MET A C   1 
ATOM   612  O O   . MET A 1 85  ? 11.57878  11.91748  -7.69634  1.000 8.97275  ? 96  MET A O   1 
ATOM   613  C CB  . MET A 1 85  ? 13.42717  14.07677  -6.46293  1.000 7.80727  ? 96  MET A CB  1 
ATOM   614  C CG  . MET A 1 85  ? 14.89381  14.45774  -6.39643  1.000 9.81794  ? 96  MET A CG  1 
ATOM   615  S SD  . MET A 1 85  ? 15.98918  13.08386  -6.82731  1.000 10.22550 ? 96  MET A SD  1 
ATOM   616  C CE  . MET A 1 85  ? 15.21765  11.67430  -6.02101  1.000 12.19537 ? 96  MET A CE  1 
ATOM   617  N N   . LEU A 1 86  ? 10.58280  13.84968  -8.30739  1.000 7.60888  ? 97  LEU A N   1 
ATOM   618  C CA  . LEU A 1 86  ? 9.24216   13.26439  -8.24423  1.000 9.35163  ? 97  LEU A CA  1 
ATOM   619  C C   . LEU A 1 86  ? 9.10000   12.00115  -9.08057  1.000 7.58704  ? 97  LEU A C   1 
ATOM   620  O O   . LEU A 1 86  ? 8.65541   10.97840  -8.53154  1.000 9.43768  ? 97  LEU A O   1 
ATOM   621  C CB  . LEU A 1 86  ? 8.17209   14.31311  -8.56689  1.000 9.91856  ? 97  LEU A CB  1 
ATOM   622  C CG  . LEU A 1 86  ? 6.72737   13.83692  -8.78856  1.000 11.53210 ? 97  LEU A CG  1 
ATOM   623  C CD1 . LEU A 1 86  ? 6.14305   13.07872  -7.61098  1.000 13.23367 ? 97  LEU A CD1 1 
ATOM   624  C CD2 . LEU A 1 86  ? 5.85763   15.03095  -9.11956  1.000 14.77005 ? 97  LEU A CD2 1 
ATOM   625  N N   . PRO A 1 87  ? 9.44309   11.97184  -10.37153 1.000 8.18472  ? 98  PRO A N   1 
ATOM   626  C CA  . PRO A 1 87  ? 9.25439   10.71029  -11.11352 1.000 10.24684 ? 98  PRO A CA  1 
ATOM   627  C C   . PRO A 1 87  ? 10.12266  9.56978   -10.60450 1.000 9.46723  ? 98  PRO A C   1 
ATOM   628  O O   . PRO A 1 87  ? 9.71226   8.40311   -10.68215 1.000 10.78075 ? 98  PRO A O   1 
ATOM   629  C CB  . PRO A 1 87  ? 9.56373   11.09168  -12.57145 1.000 11.23282 ? 98  PRO A CB  1 
ATOM   630  C CG  . PRO A 1 87  ? 10.32133  12.34187  -12.49526 1.000 13.29411 ? 98  PRO A CG  1 
ATOM   631  C CD  . PRO A 1 87  ? 9.88120   13.06766  -11.25531 1.000 10.51360 ? 98  PRO A CD  1 
ATOM   632  N N   . ILE A 1 88  ? 11.30336  9.87967   -10.06809 1.000 8.05009  ? 99  ILE A N   1 
ATOM   633  C CA  . ILE A 1 88  ? 12.17274  8.85816   -9.50307  1.000 9.82893  ? 99  ILE A CA  1 
ATOM   634  C C   . ILE A 1 88  ? 11.55357  8.25728   -8.24525  1.000 8.15046  ? 99  ILE A C   1 
ATOM   635  O O   . ILE A 1 88  ? 11.45885  7.02618   -8.10092  1.000 10.53437 ? 99  ILE A O   1 
ATOM   636  C CB  . ILE A 1 88  ? 13.55233  9.46988   -9.22460  1.000 10.65661 ? 99  ILE A CB  1 
ATOM   637  C CG1 . ILE A 1 88  ? 14.16857  9.96654   -10.54582 1.000 11.41232 ? 99  ILE A CG1 1 
ATOM   638  C CG2 . ILE A 1 88  ? 14.43251  8.47707   -8.51830  1.000 12.92681 ? 99  ILE A CG2 1 
ATOM   639  C CD1 . ILE A 1 88  ? 15.29922  10.93931  -10.35234 1.000 20.06386 ? 99  ILE A CD1 1 
ATOM   640  N N   . LEU A 1 89  ? 11.10620  9.11136   -7.32129  1.000 7.65717  ? 100 LEU A N   1 
ATOM   641  C CA  . LEU A 1 89  ? 10.48913  8.59435   -6.10078  1.000 7.49433  ? 100 LEU A CA  1 
ATOM   642  C C   . LEU A 1 89  ? 9.21116   7.82717   -6.41078  1.000 8.52685  ? 100 LEU A C   1 
ATOM   643  O O   . LEU A 1 89  ? 8.94025   6.77667   -5.80113  1.000 8.96593  ? 100 LEU A O   1 
ATOM   644  C CB  . LEU A 1 89  ? 10.19307  9.75012   -5.13593  1.000 7.37434  ? 100 LEU A CB  1 
ATOM   645  C CG  . LEU A 1 89  ? 9.62350   9.35363   -3.77278  1.000 6.86729  ? 100 LEU A CG  1 
ATOM   646  C CD1 . LEU A 1 89  ? 10.66797  8.59239   -2.95958  1.000 12.01507 ? 100 LEU A CD1 1 
ATOM   647  C CD2 . LEU A 1 89  ? 9.13153   10.60882  -3.02981  1.000 8.20403  ? 100 LEU A CD2 1 
ATOM   648  N N   . MET A 1 90  ? 8.41392   8.34357   -7.34953  1.000 8.61994  ? 101 MET A N   1 
ATOM   649  C CA  A MET A 1 90  ? 7.14303   7.71407   -7.69381  0.567 9.97035  ? 101 MET A CA  1 
ATOM   650  C CA  B MET A 1 90  ? 7.14259   7.71687   -7.69865  0.433 9.98976  ? 101 MET A CA  1 
ATOM   651  C C   . MET A 1 90  ? 7.35585   6.33484   -8.30490  1.000 11.33349 ? 101 MET A C   1 
ATOM   652  O O   . MET A 1 90  ? 6.68564   5.37020   -7.92464  1.000 10.72826 ? 101 MET A O   1 
ATOM   653  C CB  A MET A 1 90  ? 6.34993   8.61818   -8.64227  0.567 13.86121 ? 101 MET A CB  1 
ATOM   654  C CB  B MET A 1 90  ? 6.37163   8.62265   -8.66352  0.433 13.83742 ? 101 MET A CB  1 
ATOM   655  C CG  A MET A 1 90  ? 5.08569   7.97337   -9.19597  0.567 16.09062 ? 101 MET A CG  1 
ATOM   656  C CG  B MET A 1 90  ? 5.02398   8.07031   -9.10783  0.433 16.03285 ? 101 MET A CG  1 
ATOM   657  S SD  A MET A 1 90  ? 3.80579   7.76519   -7.94254  0.567 13.99873 ? 101 MET A SD  1 
ATOM   658  S SD  B MET A 1 90  ? 3.83946   9.37018   -9.51679  0.433 23.03411 ? 101 MET A SD  1 
ATOM   659  C CE  A MET A 1 90  ? 3.32072   9.46052   -7.66878  0.567 14.05287 ? 101 MET A CE  1 
ATOM   660  C CE  B MET A 1 90  ? 3.61338   10.13980  -7.91498  0.433 13.65794 ? 101 MET A CE  1 
ATOM   661  N N   . GLN A 1 91  ? 8.29095   6.21908   -9.25652  1.000 9.49634  ? 102 GLN A N   1 
ATOM   662  C CA  . GLN A 1 91  ? 8.52923   4.91940   -9.88441  1.000 9.05463  ? 102 GLN A CA  1 
ATOM   663  C C   . GLN A 1 91  ? 9.00782   3.90711   -8.86040  1.000 11.66005 ? 102 GLN A C   1 
ATOM   664  O O   . GLN A 1 91  ? 8.54865   2.75164   -8.84595  1.000 12.81293 ? 102 GLN A O   1 
ATOM   665  C CB  . GLN A 1 91  ? 9.53481   5.05306   -11.03120 1.000 11.68315 ? 102 GLN A CB  1 
ATOM   666  C CG  . GLN A 1 91  ? 9.66731   3.78134   -11.90167 1.000 17.88711 ? 102 GLN A CG  1 
ATOM   667  C CD  . GLN A 1 91  ? 10.53476  2.68147   -11.28784 1.000 38.63836 ? 102 GLN A CD  1 
ATOM   668  O OE1 . GLN A 1 91  ? 11.41424  2.93909   -10.45531 1.000 29.03792 ? 102 GLN A OE1 1 
ATOM   669  N NE2 . GLN A 1 91  ? 10.28348  1.44024   -11.70092 1.000 38.97763 ? 102 GLN A NE2 1 
ATOM   670  N N   . SER A 1 92  ? 9.91253   4.33015   -7.97172  1.000 9.76364  ? 103 SER A N   1 
ATOM   671  C CA  . SER A 1 92  ? 10.43200  3.41361   -6.96395  1.000 12.06147 ? 103 SER A CA  1 
ATOM   672  C C   . SER A 1 92  ? 9.32837   2.95834   -6.01810  1.000 9.47752  ? 103 SER A C   1 
ATOM   673  O O   . SER A 1 92  ? 9.15495   1.75746   -5.77964  1.000 9.98620  ? 103 SER A O   1 
ATOM   674  C CB  . SER A 1 92  ? 11.56354  4.08215   -6.19710  1.000 11.72164 ? 103 SER A CB  1 
ATOM   675  O OG  . SER A 1 92  ? 11.89895  3.29788   -5.06596  1.000 13.98216 ? 103 SER A OG  1 
ATOM   676  N N   . ALA A 1 93  ? 8.54816   3.90902   -5.48989  1.000 9.20430  ? 104 ALA A N   1 
ATOM   677  C CA  . ALA A 1 93  ? 7.48787   3.56213   -4.54585  1.000 8.52302  ? 104 ALA A CA  1 
ATOM   678  C C   . ALA A 1 93  ? 6.46681   2.62790   -5.18121  1.000 9.59951  ? 104 ALA A C   1 
ATOM   679  O O   . ALA A 1 93  ? 6.07665   1.61945   -4.57507  1.000 9.15108  ? 104 ALA A O   1 
ATOM   680  C CB  . ALA A 1 93  ? 6.80142   4.83430   -4.04430  1.000 11.88861 ? 104 ALA A CB  1 
ATOM   681  N N   . GLN A 1 94  ? 6.04931   2.93570   -6.42045  1.000 11.85235 ? 105 GLN A N   1 
ATOM   682  C CA  A GLN A 1 94  ? 5.03612   2.12249   -7.08490  0.606 11.79998 ? 105 GLN A CA  1 
ATOM   683  C CA  B GLN A 1 94  ? 5.04737   2.12845   -7.11532  0.394 11.85395 ? 105 GLN A CA  1 
ATOM   684  C C   . GLN A 1 94  ? 5.45590   0.66154   -7.19818  1.000 12.56296 ? 105 GLN A C   1 
ATOM   685  O O   . GLN A 1 94  ? 4.59636   -0.22779  -7.21867  1.000 15.87258 ? 105 GLN A O   1 
ATOM   686  C CB  A GLN A 1 94  ? 4.73187   2.69513   -8.47034  0.606 12.99661 ? 105 GLN A CB  1 
ATOM   687  C CB  B GLN A 1 94  ? 4.83596   2.68067   -8.53117  0.394 13.01099 ? 105 GLN A CB  1 
ATOM   688  C CG  A GLN A 1 94  ? 3.45213   2.16136   -9.07764  0.606 14.76088 ? 105 GLN A CG  1 
ATOM   689  C CG  B GLN A 1 94  ? 3.92055   3.90294   -8.62300  0.394 11.96058 ? 105 GLN A CG  1 
ATOM   690  C CD  A GLN A 1 94  ? 2.26020   2.37764   -8.17265  0.606 17.88748 ? 105 GLN A CD  1 
ATOM   691  C CD  B GLN A 1 94  ? 3.89882   4.53178   -10.01355 0.394 18.16392 ? 105 GLN A CD  1 
ATOM   692  O OE1 A GLN A 1 94  ? 1.94350   3.50939   -7.80983  0.606 14.68048 ? 105 GLN A OE1 1 
ATOM   693  O OE1 B GLN A 1 94  ? 4.77169   4.26905   -10.84488 0.394 17.27311 ? 105 GLN A OE1 1 
ATOM   694  N NE2 A GLN A 1 94  ? 1.59723   1.29036   -7.79325  0.606 17.66618 ? 105 GLN A NE2 1 
ATOM   695  N NE2 B GLN A 1 94  ? 2.89439   5.36818   -10.26894 0.394 17.23741 ? 105 GLN A NE2 1 
ATOM   696  N N   . ASN A 1 95  ? 6.75431   0.38645   -7.25913  1.000 9.41854  ? 106 ASN A N   1 
ATOM   697  C CA  . ASN A 1 95  ? 7.23615   -0.97872  -7.42777  1.000 12.65629 ? 106 ASN A CA  1 
ATOM   698  C C   . ASN A 1 95  ? 7.86532   -1.55479  -6.16563  1.000 13.30392 ? 106 ASN A C   1 
ATOM   699  O O   . ASN A 1 95  ? 8.67058   -2.48564  -6.24737  1.000 17.39478 ? 106 ASN A O   1 
ATOM   700  C CB  . ASN A 1 95  ? 8.19183   -1.03537  -8.61554  1.000 13.59281 ? 106 ASN A CB  1 
ATOM   701  C CG  . ASN A 1 95  ? 7.49756   -0.66169  -9.90650  1.000 14.93544 ? 106 ASN A CG  1 
ATOM   702  O OD1 . ASN A 1 95  ? 7.87032   0.29864   -10.57281 1.000 26.08851 ? 106 ASN A OD1 1 
ATOM   703  N ND2 . ASN A 1 95  ? 6.45090   -1.40791  -10.24370 1.000 19.12285 ? 106 ASN A ND2 1 
ATOM   704  N N   . THR A 1 96  ? 7.51302   -1.02287  -5.00046  1.000 10.48044 ? 107 THR A N   1 
ATOM   705  C CA  . THR A 1 96  ? 8.02668   -1.49475  -3.71520  1.000 11.04703 ? 107 THR A CA  1 
ATOM   706  C C   . THR A 1 96  ? 6.86434   -2.19947  -3.02518  1.000 12.95684 ? 107 THR A C   1 
ATOM   707  O O   . THR A 1 96  ? 5.94939   -1.54797  -2.50828  1.000 11.18603 ? 107 THR A O   1 
ATOM   708  C CB  . THR A 1 96  ? 8.52479   -0.32041  -2.87264  1.000 9.18835  ? 107 THR A CB  1 
ATOM   709  O OG1 . THR A 1 96  ? 9.59140   0.34801   -3.55855  1.000 11.59820 ? 107 THR A OG1 1 
ATOM   710  C CG2 . THR A 1 96  ? 9.04522   -0.82321  -1.51473  1.000 12.78901 ? 107 THR A CG2 1 
ATOM   711  N N   . LYS A 1 97  ? 6.88974   -3.53173  -3.03357  1.000 12.14763 ? 108 LYS A N   1 
ATOM   712  C CA  . LYS A 1 97  ? 5.81493   -4.29675  -2.41654  1.000 11.06511 ? 108 LYS A CA  1 
ATOM   713  C C   . LYS A 1 97  ? 5.80788   -4.04952  -0.91616  1.000 11.64281 ? 108 LYS A C   1 
ATOM   714  O O   . LYS A 1 97  ? 6.82173   -4.25897  -0.24171  1.000 16.00210 ? 108 LYS A O   1 
ATOM   715  C CB  . LYS A 1 97  ? 5.95325   -5.79307  -2.72212  1.000 15.07285 ? 108 LYS A CB  1 
ATOM   716  C CG  . LYS A 1 97  ? 5.78238   -6.24405  -4.20442  1.000 31.39234 ? 108 LYS A CG  1 
ATOM   717  C CD  . LYS A 1 97  ? 6.51832   -5.43143  -5.26681  1.000 34.81336 ? 108 LYS A CD  1 
ATOM   718  C CE  . LYS A 1 97  ? 5.78493   -5.48145  -6.61037  1.000 39.96576 ? 108 LYS A CE  1 
ATOM   719  N NZ  . LYS A 1 97  ? 6.20986   -4.41857  -7.57101  1.000 28.37594 ? 108 LYS A NZ  1 
ATOM   720  N N   . GLY A 1 98  ? 4.66935   -3.57138  -0.40812  1.000 11.89342 ? 109 GLY A N   1 
ATOM   721  C CA  . GLY A 1 98  ? 4.49370   -3.28305  0.99660   1.000 14.75345 ? 109 GLY A CA  1 
ATOM   722  C C   . GLY A 1 98  ? 4.66953   -1.82956  1.37277   1.000 13.60251 ? 109 GLY A C   1 
ATOM   723  O O   . GLY A 1 98  ? 4.34986   -1.46298  2.50907   1.000 13.37600 ? 109 GLY A O   1 
ATOM   724  N N   . ALA A 1 99  ? 5.17280   -0.98897  0.47292   1.000 12.15303 ? 110 ALA A N   1 
ATOM   725  C CA  . ALA A 1 99  ? 5.27780   0.42876   0.80232   1.000 8.77102  ? 110 ALA A CA  1 
ATOM   726  C C   . ALA A 1 99  ? 3.89973   1.08001   0.82816   1.000 10.89874 ? 110 ALA A C   1 
ATOM   727  O O   . ALA A 1 99  ? 3.11072   0.94684   -0.11805  1.000 15.64875 ? 110 ALA A O   1 
ATOM   728  C CB  . ALA A 1 99  ? 6.17776   1.16451   -0.19256  1.000 9.76294  ? 110 ALA A CB  1 
ATOM   729  N N   . LEU A 1 100 ? 3.62613   1.82148   1.89797   1.000 8.10044  ? 111 LEU A N   1 
ATOM   730  C CA  . LEU A 1 100 ? 2.36048   2.51973   2.05683   1.000 10.61872 ? 111 LEU A CA  1 
ATOM   731  C C   . LEU A 1 100 ? 2.46735   4.00333   1.71097   1.000 10.18792 ? 111 LEU A C   1 
ATOM   732  O O   . LEU A 1 100 ? 1.51706   4.59094   1.17833   1.000 11.66092 ? 111 LEU A O   1 
ATOM   733  C CB  . LEU A 1 100 ? 1.89863   2.35468   3.51211   1.000 15.31791 ? 111 LEU A CB  1 
ATOM   734  C CG  . LEU A 1 100 ? 0.55541   2.91749   3.95010   1.000 24.20081 ? 111 LEU A CG  1 
ATOM   735  C CD1 . LEU A 1 100 ? -0.56003  2.13740   3.28720   1.000 31.32449 ? 111 LEU A CD1 1 
ATOM   736  C CD2 . LEU A 1 100 ? 0.44984   2.82592   5.45790   1.000 30.90110 ? 111 LEU A CD2 1 
ATOM   737  N N   . THR A 1 101 ? 3.60627   4.63101   2.01827   1.000 9.71536  ? 112 THR A N   1 
ATOM   738  C CA  . THR A 1 101 ? 3.87418   6.02225   1.65469   1.000 9.59636  ? 112 THR A CA  1 
ATOM   739  C C   . THR A 1 101 ? 5.34331   6.14368   1.28381   1.000 9.47665  ? 112 THR A C   1 
ATOM   740  O O   . THR A 1 101 ? 6.15696   5.28933   1.63310   1.000 9.79462  ? 112 THR A O   1 
ATOM   741  C CB  . THR A 1 101 ? 3.61862   7.02151   2.79675   1.000 10.37519 ? 112 THR A CB  1 
ATOM   742  O OG1 . THR A 1 101 ? 4.70067   6.95796   3.73200   1.000 19.04680 ? 112 THR A OG1 1 
ATOM   743  C CG2 . THR A 1 101 ? 2.31479   6.74700   3.51229   1.000 10.95639 ? 112 THR A CG2 1 
ATOM   744  N N   . ALA A 1 102 ? 5.68017   7.22045   0.57139   1.000 6.19870  ? 113 ALA A N   1 
ATOM   745  C CA  . ALA A 1 102 ? 7.06672   7.52735   0.25256   1.000 5.56175  ? 113 ALA A CA  1 
ATOM   746  C C   . ALA A 1 102 ? 7.22488   9.04155   0.29281   1.000 6.72990  ? 113 ALA A C   1 
ATOM   747  O O   . ALA A 1 102 ? 6.28563   9.77443   -0.02492  1.000 7.42395  ? 113 ALA A O   1 
ATOM   748  C CB  . ALA A 1 102 ? 7.44076   7.01228   -1.15105  1.000 6.25922  ? 113 ALA A CB  1 
ATOM   749  N N   . TYR A 1 103 ? 8.39934   9.52347   0.70923   1.000 4.86380  ? 114 TYR A N   1 
ATOM   750  C CA  . TYR A 1 103 ? 8.49214   10.96679  0.92452   1.000 3.68040  ? 114 TYR A CA  1 
ATOM   751  C C   . TYR A 1 103 ? 9.94100   11.44476  0.85160   1.000 4.52883  ? 114 TYR A C   1 
ATOM   752  O O   . TYR A 1 103 ? 10.87494  10.71183  1.18419   1.000 6.38170  ? 114 TYR A O   1 
ATOM   753  C CB  . TYR A 1 103 ? 7.85786   11.37267  2.26556   1.000 5.08791  ? 114 TYR A CB  1 
ATOM   754  C CG  . TYR A 1 103 ? 8.11095   10.41186  3.41279   1.000 4.86256  ? 114 TYR A CG  1 
ATOM   755  C CD1 . TYR A 1 103 ? 7.26469   9.32302   3.63688   1.000 5.63920  ? 114 TYR A CD1 1 
ATOM   756  C CD2 . TYR A 1 103 ? 9.17710   10.61258  4.28451   1.000 5.74917  ? 114 TYR A CD2 1 
ATOM   757  C CE1 . TYR A 1 103 ? 7.47200   8.43927   4.69975   1.000 5.25736  ? 114 TYR A CE1 1 
ATOM   758  C CE2 . TYR A 1 103 ? 9.39924   9.73098   5.36229   1.000 6.44980  ? 114 TYR A CE2 1 
ATOM   759  C CZ  . TYR A 1 103 ? 8.54215   8.65332   5.55406   1.000 5.18841  ? 114 TYR A CZ  1 
ATOM   760  O OH  . TYR A 1 103 ? 8.76076   7.79666   6.61966   1.000 7.30426  ? 114 TYR A OH  1 
ATOM   761  N N   . ILE A 1 104 ? 10.10534  12.69832  0.43259   1.000 4.54430  ? 115 ILE A N   1 
ATOM   762  C CA  . ILE A 1 104 ? 11.34270  13.45346  0.57959   1.000 5.00746  ? 115 ILE A CA  1 
ATOM   763  C C   . ILE A 1 104 ? 10.93235  14.78445  1.19543   1.000 5.53719  ? 115 ILE A C   1 
ATOM   764  O O   . ILE A 1 104 ? 10.12626  15.51636  0.60314   1.000 5.08421  ? 115 ILE A O   1 
ATOM   765  C CB  . ILE A 1 104 ? 12.03181  13.68788  -0.78206  1.000 4.80316  ? 115 ILE A CB  1 
ATOM   766  C CG1 . ILE A 1 104 ? 12.47701  12.35050  -1.37260  1.000 6.09093  ? 115 ILE A CG1 1 
ATOM   767  C CG2 . ILE A 1 104 ? 13.23459  14.60238  -0.60601  1.000 8.98905  ? 115 ILE A CG2 1 
ATOM   768  C CD1 . ILE A 1 104 ? 13.03635  12.46632  -2.81459  1.000 8.41991  ? 115 ILE A CD1 1 
ATOM   769  N N   . ARG A 1 105 ? 11.42785  15.07380  2.39817   1.000 5.36576  ? 116 ARG A N   1 
ATOM   770  C CA  . ARG A 1 105 ? 11.08140  16.31071  3.09079   1.000 4.37100  ? 116 ARG A CA  1 
ATOM   771  C C   . ARG A 1 105 ? 12.35725  17.03381  3.47930   1.000 6.07519  ? 116 ARG A C   1 
ATOM   772  O O   . ARG A 1 105 ? 13.41939  16.42119  3.57377   1.000 7.13198  ? 116 ARG A O   1 
ATOM   773  C CB  . ARG A 1 105 ? 10.18966  16.08098  4.33358   1.000 6.00407  ? 116 ARG A CB  1 
ATOM   774  C CG  . ARG A 1 105 ? 8.91770   15.25206  4.05172   1.000 5.74776  ? 116 ARG A CG  1 
ATOM   775  C CD  . ARG A 1 105 ? 7.93091   15.92684  3.06580   1.000 5.06948  ? 116 ARG A CD  1 
ATOM   776  N NE  . ARG A 1 105 ? 7.79491   17.35260  3.33329   1.000 5.36044  ? 116 ARG A NE  1 
ATOM   777  C CZ  . ARG A 1 105 ? 7.07048   17.89484  4.31059   1.000 5.52626  ? 116 ARG A CZ  1 
ATOM   778  N NH1 . ARG A 1 105 ? 6.33648   17.14935  5.13505   1.000 6.07289  ? 116 ARG A NH1 1 
ATOM   779  N NH2 . ARG A 1 105 ? 7.08370   19.21751  4.46595   1.000 6.60969  ? 116 ARG A NH2 1 
ATOM   780  N N   . TYR A 1 106 ? 12.25230  18.35169  3.69111   1.000 5.30060  ? 117 TYR A N   1 
ATOM   781  C CA  . TYR A 1 106 ? 13.43399  19.17164  3.91058   1.000 5.13595  ? 117 TYR A CA  1 
ATOM   782  C C   . TYR A 1 106 ? 13.40180  19.85213  5.27380   1.000 7.43231  ? 117 TYR A C   1 
ATOM   783  O O   . TYR A 1 106 ? 12.34516  20.00253  5.90770   1.000 7.02558  ? 117 TYR A O   1 
ATOM   784  C CB  . TYR A 1 106 ? 13.57982  20.22002  2.79854   1.000 4.80970  ? 117 TYR A CB  1 
ATOM   785  C CG  . TYR A 1 106 ? 13.48690  19.64461  1.40294   1.000 5.34925  ? 117 TYR A CG  1 
ATOM   786  C CD1 . TYR A 1 106 ? 14.29664  18.56809  1.00607   1.000 7.14721  ? 117 TYR A CD1 1 
ATOM   787  C CD2 . TYR A 1 106 ? 12.57601  20.15617  0.48820   1.000 6.22189  ? 117 TYR A CD2 1 
ATOM   788  C CE1 . TYR A 1 106 ? 14.20989  18.03003  -0.28762  1.000 8.51271  ? 117 TYR A CE1 1 
ATOM   789  C CE2 . TYR A 1 106 ? 12.48922  19.64300  -0.80193  1.000 7.18937  ? 117 TYR A CE2 1 
ATOM   790  C CZ  . TYR A 1 106 ? 13.30340  18.58000  -1.18186  1.000 8.60880  ? 117 TYR A CZ  1 
ATOM   791  O OH  . TYR A 1 106 ? 13.19442  18.07858  -2.46239  1.000 8.84944  ? 117 TYR A OH  1 
ATOM   792  N N   . ASN A 1 107 ? 14.58745  20.27355  5.70250   1.000 5.66027  ? 118 ASN A N   1 
ATOM   793  C CA  . ASN A 1 107 ? 14.79070  20.92304  6.99721   1.000 7.14234  ? 118 ASN A CA  1 
ATOM   794  C C   . ASN A 1 107 ? 13.91080  22.17043  7.10474   1.000 7.41135  ? 118 ASN A C   1 
ATOM   795  O O   . ASN A 1 107 ? 14.05932  23.09865  6.29007   1.000 7.18993  ? 118 ASN A O   1 
ATOM   796  C CB  . ASN A 1 107 ? 16.26548  21.30840  7.09323   1.000 10.26787 ? 118 ASN A CB  1 
ATOM   797  C CG  . ASN A 1 107 ? 16.66497  21.79121  8.47524   1.000 8.79082  ? 118 ASN A CG  1 
ATOM   798  O OD1 . ASN A 1 107 ? 15.85713  22.37827  9.19137   1.000 10.24454 ? 118 ASN A OD1 1 
ATOM   799  N ND2 . ASN A 1 107 ? 17.92260  21.56559  8.84955   1.000 11.49046 ? 118 ASN A ND2 1 
ATOM   800  N N   . PRO A 1 108 ? 13.00760  22.24532  8.09503   1.000 6.91352  ? 119 PRO A N   1 
ATOM   801  C CA  . PRO A 1 108 ? 12.07496  23.38474  8.17035   1.000 8.22619  ? 119 PRO A CA  1 
ATOM   802  C C   . PRO A 1 108 ? 12.73128  24.67095  8.63747   1.000 10.87927 ? 119 PRO A C   1 
ATOM   803  O O   . PRO A 1 108 ? 12.07536  25.72122  8.62120   1.000 10.56682 ? 119 PRO A O   1 
ATOM   804  C CB  . PRO A 1 108 ? 11.01576  22.91094  9.17948   1.000 10.82435 ? 119 PRO A CB  1 
ATOM   805  C CG  . PRO A 1 108 ? 11.71994  21.90547  10.01613  1.000 10.33851 ? 119 PRO A CG  1 
ATOM   806  C CD  . PRO A 1 108 ? 12.71507  21.20046  9.08749   1.000 7.36818  ? 119 PRO A CD  1 
ATOM   807  N N   . GLU A 1 109 ? 14.00422  24.62840  9.03168   1.000 8.83793  ? 120 GLU A N   1 
ATOM   808  C CA  . GLU A 1 109 ? 14.68698  25.85862  9.43252   1.000 11.01327 ? 120 GLU A CA  1 
ATOM   809  C C   . GLU A 1 109 ? 14.91869  26.80013  8.25168   1.000 12.72333 ? 120 GLU A C   1 
ATOM   810  O O   . GLU A 1 109 ? 15.00339  28.02196  8.44981   1.000 16.77208 ? 120 GLU A O   1 
ATOM   811  C CB  . GLU A 1 109 ? 16.00532  25.50913  10.12821  1.000 14.16921 ? 120 GLU A CB  1 
ATOM   812  C CG  . GLU A 1 109 ? 16.72079  26.71287  10.78599  1.000 19.73731 ? 120 GLU A CG  1 
ATOM   813  C CD  . GLU A 1 109 ? 18.07771  27.04248  10.17692  1.000 31.00405 ? 120 GLU A CD  1 
ATOM   814  O OE1 . GLU A 1 109 ? 18.90361  26.11676  9.96006   1.000 33.86930 ? 120 GLU A OE1 1 
ATOM   815  O OE2 . GLU A 1 109 ? 18.32588  28.24468  9.94481   1.000 28.56514 ? 120 GLU A OE2 1 
ATOM   816  N N   . PHE A 1 110 ? 15.02065  26.26725  7.01986   1.000 9.21238  ? 121 PHE A N   1 
ATOM   817  C CA  . PHE A 1 110 ? 15.34233  27.09987  5.86464   1.000 8.95001  ? 121 PHE A CA  1 
ATOM   818  C C   . PHE A 1 110 ? 14.54494  26.77017  4.60042   1.000 11.37425 ? 121 PHE A C   1 
ATOM   819  O O   . PHE A 1 110 ? 14.84723  27.33311  3.53900   1.000 14.28743 ? 121 PHE A O   1 
ATOM   820  C CB  . PHE A 1 110 ? 16.85190  27.11420  5.56797   1.000 10.70426 ? 121 PHE A CB  1 
ATOM   821  C CG  . PHE A 1 110 ? 17.46992  25.74350  5.44923   1.000 11.38294 ? 121 PHE A CG  1 
ATOM   822  C CD1 . PHE A 1 110 ? 17.35157  25.00354  4.27473   1.000 8.44998  ? 121 PHE A CD1 1 
ATOM   823  C CD2 . PHE A 1 110 ? 18.17178  25.19518  6.51476   1.000 9.82717  ? 121 PHE A CD2 1 
ATOM   824  C CE1 . PHE A 1 110 ? 17.92235  23.73852  4.17899   1.000 11.56108 ? 121 PHE A CE1 1 
ATOM   825  C CE2 . PHE A 1 110 ? 18.74394  23.94418  6.41752   1.000 11.88072 ? 121 PHE A CE2 1 
ATOM   826  C CZ  . PHE A 1 110 ? 18.61836  23.21298  5.25420   1.000 12.18651 ? 121 PHE A CZ  1 
ATOM   827  N N   . THR A 1 111 ? 13.54704  25.89163  4.66242   1.000 9.42299  ? 122 THR A N   1 
ATOM   828  C CA  . THR A 1 111 ? 12.67591  25.63508  3.51871   1.000 6.70564  ? 122 THR A CA  1 
ATOM   829  C C   . THR A 1 111 ? 11.22068  25.83738  3.91989   1.000 9.50912  ? 122 THR A C   1 
ATOM   830  O O   . THR A 1 111 ? 10.88217  25.85908  5.10576   1.000 10.91879 ? 122 THR A O   1 
ATOM   831  C CB  . THR A 1 111 ? 12.84983  24.20635  2.97610   1.000 7.82567  ? 122 THR A CB  1 
ATOM   832  O OG1 . THR A 1 111 ? 12.50806  23.27169  4.00549   1.000 7.84684  ? 122 THR A OG1 1 
ATOM   833  C CG2 . THR A 1 111 ? 14.28895  23.95372  2.52609   1.000 10.65133 ? 122 THR A CG2 1 
ATOM   834  N N   . GLU A 1 112 ? 10.35776  25.97839  2.91341   1.000 9.22770  ? 123 GLU A N   1 
ATOM   835  C CA  . GLU A 1 112 ? 8.93783   26.16074  3.17859   1.000 10.11143 ? 123 GLU A CA  1 
ATOM   836  C C   . GLU A 1 112 ? 8.37676   24.88521  3.82191   1.000 11.62691 ? 123 GLU A C   1 
ATOM   837  O O   . GLU A 1 112 ? 8.79583   23.77256  3.47723   1.000 9.98916  ? 123 GLU A O   1 
ATOM   838  C CB  . GLU A 1 112 ? 8.22931   26.45534  1.85756   1.000 11.10100 ? 123 GLU A CB  1 
ATOM   839  C CG  . GLU A 1 112 ? 8.37296   27.89531  1.39196   1.000 13.44207 ? 123 GLU A CG  1 
ATOM   840  C CD  . GLU A 1 112 ? 7.30298   28.26429  0.38022   1.000 42.59999 ? 123 GLU A CD  1 
ATOM   841  O OE1 . GLU A 1 112 ? 6.10454   28.05660  0.67586   1.000 56.35219 ? 123 GLU A OE1 1 
ATOM   842  O OE2 . GLU A 1 112 ? 7.65927   28.75015  -0.71289  1.000 48.60813 ? 123 GLU A OE2 1 
ATOM   843  N N   . PRO A 1 113 ? 7.44027   24.99757  4.76563   1.000 7.08341  ? 124 PRO A N   1 
ATOM   844  C CA  . PRO A 1 113 ? 7.12341   23.84202  5.62208   1.000 7.48112  ? 124 PRO A CA  1 
ATOM   845  C C   . PRO A 1 113 ? 6.26852   22.76993  4.95877   1.000 8.06290  ? 124 PRO A C   1 
ATOM   846  O O   . PRO A 1 113 ? 6.06178   21.71777  5.57542   1.000 8.82779  ? 124 PRO A O   1 
ATOM   847  C CB  . PRO A 1 113 ? 6.43304   24.48182  6.84444   1.000 10.62559 ? 124 PRO A CB  1 
ATOM   848  C CG  . PRO A 1 113 ? 5.86673   25.77826  6.31278   1.000 11.32271 ? 124 PRO A CG  1 
ATOM   849  C CD  . PRO A 1 113 ? 6.82161   26.24544  5.25427   1.000 8.75815  ? 124 PRO A CD  1 
ATOM   850  N N   . THR A 1 114 ? 5.78266   22.98221  3.72616   1.000 9.46239  ? 125 THR A N   1 
ATOM   851  C CA  . THR A 1 114 ? 5.16214   21.90892  2.94051   1.000 8.80209  ? 125 THR A CA  1 
ATOM   852  C C   . THR A 1 114 ? 5.94984   21.59225  1.66997   1.000 9.43728  ? 125 THR A C   1 
ATOM   853  O O   . THR A 1 114 ? 5.40393   20.97955  0.73748   1.000 10.40047 ? 125 THR A O   1 
ATOM   854  C CB  . THR A 1 114 ? 3.69846   22.19915  2.58061   1.000 11.70095 ? 125 THR A CB  1 
ATOM   855  O OG1 . THR A 1 114 ? 3.63016   23.36615  1.75156   1.000 15.48882 ? 125 THR A OG1 1 
ATOM   856  C CG2 . THR A 1 114 ? 2.86043   22.42253  3.83610   1.000 11.46710 ? 125 THR A CG2 1 
ATOM   857  N N   . SER A 1 115 ? 7.21654   21.99806  1.60887   1.000 8.14991  ? 126 SER A N   1 
ATOM   858  C CA  . SER A 1 115 ? 8.05793   21.68455  0.45986   1.000 8.37817  ? 126 SER A CA  1 
ATOM   859  C C   . SER A 1 115 ? 8.34402   20.18034  0.40512   1.000 6.79589  ? 126 SER A C   1 
ATOM   860  O O   . SER A 1 115 ? 8.15113   19.44190  1.37588   1.000 7.85724  ? 126 SER A O   1 
ATOM   861  C CB  . SER A 1 115 ? 9.38509   22.45041  0.53698   1.000 8.33743  ? 126 SER A CB  1 
ATOM   862  O OG  . SER A 1 115 ? 10.06931  22.16324  1.75050   1.000 8.38990  ? 126 SER A OG  1 
ATOM   863  N N   . GLY A 1 116 ? 8.81774   19.72467  -0.75237  1.000 5.82983  ? 127 GLY A N   1 
ATOM   864  C CA  . GLY A 1 116 ? 9.14070   18.32023  -0.92647  1.000 7.29912  ? 127 GLY A CA  1 
ATOM   865  C C   . GLY A 1 116 ? 8.01442   17.47239  -1.48247  1.000 9.21506  ? 127 GLY A C   1 
ATOM   866  O O   . GLY A 1 116 ? 7.13673   17.98832  -2.18540  1.000 7.60075  ? 127 GLY A O   1 
ATOM   867  N N   . LEU A 1 117 ? 8.02547   16.16748  -1.16484  1.000 6.20069  ? 128 LEU A N   1 
ATOM   868  C CA  . LEU A 1 117 ? 7.11693   15.19151  -1.76056  1.000 6.66031  ? 128 LEU A CA  1 
ATOM   869  C C   . LEU A 1 117 ? 6.55196   14.27363  -0.68741  1.000 7.49663  ? 128 LEU A C   1 
ATOM   870  O O   . LEU A 1 117 ? 7.27204   13.83461  0.21308   1.000 6.61304  ? 128 LEU A O   1 
ATOM   871  C CB  . LEU A 1 117 ? 7.84025   14.31481  -2.79446  1.000 5.76790  ? 128 LEU A CB  1 
ATOM   872  C CG  . LEU A 1 117 ? 8.42302   15.11071  -3.96592  1.000 9.06986  ? 128 LEU A CG  1 
ATOM   873  C CD1 . LEU A 1 117 ? 9.29294   14.20971  -4.78540  1.000 9.98161  ? 128 LEU A CD1 1 
ATOM   874  C CD2 . LEU A 1 117 ? 7.30414   15.68455  -4.80994  1.000 10.48417 ? 128 LEU A CD2 1 
ATOM   875  N N   . PHE A 1 118 ? 5.26540   13.94337  -0.82199  1.000 6.32616  ? 129 PHE A N   1 
ATOM   876  C CA  . PHE A 1 118 ? 4.58485   12.97885  0.04437   1.000 5.22776  ? 129 PHE A CA  1 
ATOM   877  C C   . PHE A 1 118 ? 3.67037   12.19261  -0.87618  1.000 5.45284  ? 129 PHE A C   1 
ATOM   878  O O   . PHE A 1 118 ? 2.74121   12.77043  -1.45213  1.000 8.62218  ? 129 PHE A O   1 
ATOM   879  C CB  . PHE A 1 118 ? 3.76930   13.71993  1.11651   1.000 7.10291  ? 129 PHE A CB  1 
ATOM   880  C CG  . PHE A 1 118 ? 3.10725   12.82762  2.15658   1.000 7.33664  ? 129 PHE A CG  1 
ATOM   881  C CD1 . PHE A 1 118 ? 3.64061   11.59359  2.50218   1.000 6.12235  ? 129 PHE A CD1 1 
ATOM   882  C CD2 . PHE A 1 118 ? 1.97286   13.26523  2.82244   1.000 10.32748 ? 129 PHE A CD2 1 
ATOM   883  C CE1 . PHE A 1 118 ? 3.05241   10.80958  3.49836   1.000 8.77541  ? 129 PHE A CE1 1 
ATOM   884  C CE2 . PHE A 1 118 ? 1.37074   12.47961  3.80061   1.000 9.99158  ? 129 PHE A CE2 1 
ATOM   885  C CZ  . PHE A 1 118 ? 1.90575   11.26276  4.13088   1.000 8.81335  ? 129 PHE A CZ  1 
ATOM   886  N N   . LEU A 1 119 ? 3.96686   10.90724  -1.06244  1.000 6.84124  ? 130 LEU A N   1 
ATOM   887  C CA  . LEU A 1 119 ? 3.19342   10.02994  -1.93518  1.000 6.17628  ? 130 LEU A CA  1 
ATOM   888  C C   . LEU A 1 119 ? 2.47879   8.99682   -1.08117  1.000 8.81288  ? 130 LEU A C   1 
ATOM   889  O O   . LEU A 1 119 ? 3.08733   8.40139   -0.19273  1.000 9.62675  ? 130 LEU A O   1 
ATOM   890  C CB  . LEU A 1 119 ? 4.07764   9.29742   -2.94302  1.000 7.28685  ? 130 LEU A CB  1 
ATOM   891  C CG  . LEU A 1 119 ? 5.14605   10.10951  -3.68048  1.000 7.56063  ? 130 LEU A CG  1 
ATOM   892  C CD1 . LEU A 1 119 ? 5.82463   9.16223   -4.65928  1.000 9.01903  ? 130 LEU A CD1 1 
ATOM   893  C CD2 . LEU A 1 119 ? 4.57784   11.33142  -4.39717  1.000 9.40722  ? 130 LEU A CD2 1 
ATOM   894  N N   . THR A 1 120 ? 1.19439   8.77360   -1.35064  1.000 7.91884  ? 131 THR A N   1 
ATOM   895  C CA  . THR A 1 120 ? 0.40718   7.88026   -0.51500  1.000 10.11862 ? 131 THR A CA  1 
ATOM   896  C C   . THR A 1 120 ? -0.39604  6.94057   -1.39399  1.000 12.07955 ? 131 THR A C   1 
ATOM   897  O O   . THR A 1 120 ? -0.69942  7.24637   -2.54512  1.000 14.84884 ? 131 THR A O   1 
ATOM   898  C CB  . THR A 1 120 ? -0.55498  8.62812   0.42715   1.000 11.28932 ? 131 THR A CB  1 
ATOM   899  O OG1 . THR A 1 120 ? -1.46007  9.42735   -0.33961  1.000 16.42355 ? 131 THR A OG1 1 
ATOM   900  C CG2 . THR A 1 120 ? 0.20158   9.52913   1.39300   1.000 12.40392 ? 131 THR A CG2 1 
ATOM   901  N N   . ARG A 1 121 ? -0.73635  5.78799   -0.82895  1.000 18.33330 ? 132 ARG A N   1 
ATOM   902  C CA  . ARG A 1 121 ? -1.72761  4.91546   -1.43775  1.000 26.86189 ? 132 ARG A CA  1 
ATOM   903  C C   . ARG A 1 121 ? -2.41850  4.13507   -0.33204  1.000 26.73679 ? 132 ARG A C   1 
ATOM   904  O O   . ARG A 1 121 ? -1.93276  4.05940   0.80019   1.000 36.11361 ? 132 ARG A O   1 
ATOM   905  C CB  . ARG A 1 121 ? -1.11587  3.97408   -2.47806  1.000 22.17137 ? 132 ARG A CB  1 
ATOM   906  C CG  . ARG A 1 121 ? 0.00338   3.11416   -1.95844  1.000 21.86558 ? 132 ARG A CG  1 
ATOM   907  C CD  . ARG A 1 121 ? 0.16055   1.89035   -2.84247  1.000 27.15027 ? 132 ARG A CD  1 
ATOM   908  N NE  . ARG A 1 121 ? 1.31689   1.09568   -2.45330  1.000 29.95350 ? 132 ARG A NE  1 
ATOM   909  C CZ  . ARG A 1 121 ? 2.00894   0.31786   -3.27433  1.000 32.57837 ? 132 ARG A CZ  1 
ATOM   910  N NH1 . ARG A 1 121 ? 1.65950   0.16341   -4.54261  1.000 34.50490 ? 132 ARG A NH1 1 
ATOM   911  N NH2 . ARG A 1 121 ? 3.08635   -0.30997  -2.81438  1.000 19.75291 ? 132 ARG A NH2 1 
ATOM   912  N N   . ASP A 1 122 ? -3.57284  3.56570   -0.66618  1.000 37.42194 ? 133 ASP A N   1 
ATOM   913  C CA  . ASP A 1 122 ? -4.32260  2.81595   0.33527   1.000 45.08304 ? 133 ASP A CA  1 
ATOM   914  C C   . ASP A 1 122 ? -3.79621  1.39315   0.48657   1.000 43.60810 ? 133 ASP A C   1 
ATOM   915  O O   . ASP A 1 122 ? -3.69410  0.88325   1.60801   1.000 45.31861 ? 133 ASP A O   1 
ATOM   916  C CB  . ASP A 1 122 ? -5.80523  2.80620   -0.02991  1.000 48.06021 ? 133 ASP A CB  1 
ATOM   917  C CG  . ASP A 1 122 ? -6.35567  4.20011   -0.24919  1.000 57.07639 ? 133 ASP A CG  1 
ATOM   918  O OD1 . ASP A 1 122 ? -6.24365  5.03431   0.67550   1.000 52.09139 ? 133 ASP A OD1 1 
ATOM   919  O OD2 . ASP A 1 122 ? -6.89037  4.46349   -1.34883  1.000 58.06950 ? 133 ASP A OD2 1 
ATOM   920  N N   . ASN A 1 123 ? -3.44340  0.74845   -0.62283  1.000 41.31889 ? 134 ASN A N   1 
ATOM   921  C CA  . ASN A 1 123 ? -3.08805  -0.66339  -0.61196  1.000 50.40909 ? 134 ASN A CA  1 
ATOM   922  C C   . ASN A 1 123 ? -2.20759  -0.95824  -1.81699  1.000 51.68596 ? 134 ASN A C   1 
ATOM   923  O O   . ASN A 1 123 ? -2.16427  -0.18630  -2.77891  1.000 54.12272 ? 134 ASN A O   1 
ATOM   924  C CB  . ASN A 1 123 ? -4.34627  -1.53130  -0.65371  1.000 49.25858 ? 134 ASN A CB  1 
ATOM   925  C CG  . ASN A 1 123 ? -5.34572  -1.04182  -1.68153  1.000 46.20629 ? 134 ASN A CG  1 
ATOM   926  O OD1 . ASN A 1 123 ? -5.09304  -1.09376  -2.88612  1.000 50.48745 ? 134 ASN A OD1 1 
ATOM   927  N ND2 . ASN A 1 123 ? -6.47740  -0.53529  -1.20932  1.000 50.13444 ? 134 ASN A ND2 1 
ATOM   928  N N   . SER A 1 124 ? -1.52511  -2.10792  -1.76268  1.000 49.61851 ? 135 SER A N   1 
ATOM   929  C CA  . SER A 1 124 ? -0.58054  -2.47473  -2.81530  1.000 51.85858 ? 135 SER A CA  1 
ATOM   930  C C   . SER A 1 124 ? -1.24281  -2.60889  -4.18286  1.000 50.65075 ? 135 SER A C   1 
ATOM   931  O O   . SER A 1 124 ? -0.54191  -2.59573  -5.20131  1.000 55.45804 ? 135 SER A O   1 
ATOM   932  C CB  . SER A 1 124 ? 0.15986   -3.76507  -2.44635  1.000 51.02391 ? 135 SER A CB  1 
ATOM   933  O OG  . SER A 1 124 ? 1.56920   -3.59423  -2.52754  1.000 48.94886 ? 135 SER A OG  1 
ATOM   934  N N   . ASP A 1 125 ? -2.56962  -2.73079  -4.23278  1.000 53.35698 ? 136 ASP A N   1 
ATOM   935  C CA  . ASP A 1 125 ? -3.28431  -2.80892  -5.50025  1.000 53.45066 ? 136 ASP A CA  1 
ATOM   936  C C   . ASP A 1 125 ? -3.62498  -1.44210  -6.08075  1.000 56.05539 ? 136 ASP A C   1 
ATOM   937  O O   . ASP A 1 125 ? -3.96200  -1.35304  -7.26783  1.000 55.06372 ? 136 ASP A O   1 
ATOM   938  C CB  . ASP A 1 125 ? -4.57328  -3.61998  -5.32977  1.000 60.75234 ? 136 ASP A CB  1 
ATOM   939  C CG  . ASP A 1 125 ? -4.30908  -5.05064  -4.89851  1.000 68.64298 ? 136 ASP A CG  1 
ATOM   940  O OD1 . ASP A 1 125 ? -3.55113  -5.75419  -5.60124  1.000 59.05461 ? 136 ASP A OD1 1 
ATOM   941  O OD2 . ASP A 1 125 ? -4.85814  -5.47015  -3.85597  1.000 67.41640 ? 136 ASP A OD2 1 
ATOM   942  N N   . SER A 1 126 ? -3.54701  -0.38346  -5.28343  1.000 49.40958 ? 137 SER A N   1 
ATOM   943  C CA  . SER A 1 126 ? -3.87794  0.95690   -5.73833  1.000 46.61273 ? 137 SER A CA  1 
ATOM   944  C C   . SER A 1 126 ? -2.61669  1.71524   -6.13761  1.000 41.98939 ? 137 SER A C   1 
ATOM   945  O O   . SER A 1 126 ? -1.48685  1.29368   -5.87247  1.000 33.71842 ? 137 SER A O   1 
ATOM   946  C CB  . SER A 1 126 ? -4.65659  1.71607   -4.65901  1.000 45.94361 ? 137 SER A CB  1 
ATOM   947  O OG  . SER A 1 126 ? -4.22021  1.34679   -3.36142  1.000 48.35304 ? 137 SER A OG  1 
ATOM   948  N N   . GLU A 1 127 ? -2.82624  2.85105   -6.79271  1.000 34.30337 ? 138 GLU A N   1 
ATOM   949  C CA  . GLU A 1 127 ? -1.72363  3.65237   -7.28962  1.000 19.95458 ? 138 GLU A CA  1 
ATOM   950  C C   . GLU A 1 127 ? -1.32911  4.70231   -6.26105  1.000 16.16606 ? 138 GLU A C   1 
ATOM   951  O O   . GLU A 1 127 ? -2.16164  5.19337   -5.49441  1.000 25.48647 ? 138 GLU A O   1 
ATOM   952  C CB  . GLU A 1 127 ? -2.11255  4.33933   -8.59964  1.000 28.27074 ? 138 GLU A CB  1 
ATOM   953  C CG  . GLU A 1 127 ? -1.08384  4.16209   -9.70450  1.000 46.29826 ? 138 GLU A CG  1 
ATOM   954  C CD  . GLU A 1 127 ? -0.98486  2.71944   -10.18846 1.000 47.20246 ? 138 GLU A CD  1 
ATOM   955  O OE1 . GLU A 1 127 ? -1.93459  1.93989   -9.95755  1.000 53.19450 ? 138 GLU A OE1 1 
ATOM   956  O OE2 . GLU A 1 127 ? 0.05190   2.36054   -10.79159 1.000 53.07954 ? 138 GLU A OE2 1 
ATOM   957  N N   . PHE A 1 128 ? -0.04166  5.03492   -6.25201  1.000 18.19498 ? 139 PHE A N   1 
ATOM   958  C CA  . PHE A 1 128 ? 0.43212   6.15138   -5.45057  1.000 13.70704 ? 139 PHE A CA  1 
ATOM   959  C C   . PHE A 1 128 ? -0.02225  7.46386   -6.07255  1.000 16.66454 ? 139 PHE A C   1 
ATOM   960  O O   . PHE A 1 128 ? -0.04096  7.61841   -7.30186  1.000 17.85578 ? 139 PHE A O   1 
ATOM   961  C CB  . PHE A 1 128 ? 1.95578   6.13959   -5.40797  1.000 13.72372 ? 139 PHE A CB  1 
ATOM   962  C CG  . PHE A 1 128 ? 2.52342   5.30710   -4.29942  1.000 10.73752 ? 139 PHE A CG  1 
ATOM   963  C CD1 . PHE A 1 128 ? 2.66512   5.84721   -3.03097  1.000 10.97852 ? 139 PHE A CD1 1 
ATOM   964  C CD2 . PHE A 1 128 ? 2.94142   4.00075   -4.52313  1.000 15.77969 ? 139 PHE A CD2 1 
ATOM   965  C CE1 . PHE A 1 128 ? 3.19565   5.09833   -1.99414  1.000 15.26913 ? 139 PHE A CE1 1 
ATOM   966  C CE2 . PHE A 1 128 ? 3.48274   3.24860   -3.49800  1.000 15.76371 ? 139 PHE A CE2 1 
ATOM   967  C CZ  . PHE A 1 128 ? 3.60481   3.80152   -2.22436  1.000 14.01466 ? 139 PHE A CZ  1 
ATOM   968  N N   . GLU A 1 129 ? -0.37331  8.41925   -5.21446  1.000 13.17925 ? 140 GLU A N   1 
ATOM   969  C CA  . GLU A 1 129 ? -0.70714  9.77479   -5.61916  1.000 16.49964 ? 140 GLU A CA  1 
ATOM   970  C C   . GLU A 1 129 ? 0.18679   10.75783  -4.87336  1.000 13.99358 ? 140 GLU A C   1 
ATOM   971  O O   . GLU A 1 129 ? 0.54673   10.52829  -3.71351  1.000 12.02742 ? 140 GLU A O   1 
ATOM   972  C CB  . GLU A 1 129 ? -2.17943  10.09152  -5.31554  1.000 20.10290 ? 140 GLU A CB  1 
ATOM   973  C CG  . GLU A 1 129 ? -3.13231  9.65341   -6.42123  1.000 39.49348 ? 140 GLU A CG  1 
ATOM   974  C CD  . GLU A 1 129 ? -4.53705  9.38986   -5.91756  1.000 54.84416 ? 140 GLU A CD  1 
ATOM   975  O OE1 . GLU A 1 129 ? -4.75197  9.46985   -4.68850  1.000 56.90048 ? 140 GLU A OE1 1 
ATOM   976  O OE2 . GLU A 1 129 ? -5.42354  9.09393   -6.75080  1.000 53.99747 ? 140 GLU A OE2 1 
ATOM   977  N N   . SER A 1 130 ? 0.53837   11.85399  -5.53847  1.000 11.91300 ? 141 SER A N   1 
ATOM   978  C CA  . SER A 1 130 ? 1.33360   12.91064  -4.92383  1.000 8.92343  ? 141 SER A CA  1 
ATOM   979  C C   . SER A 1 130 ? 0.40215   13.89094  -4.22172  1.000 12.86985 ? 141 SER A C   1 
ATOM   980  O O   . SER A 1 130 ? -0.42768  14.53457  -4.87209  1.000 12.90147 ? 141 SER A O   1 
ATOM   981  C CB  . SER A 1 130 ? 2.15458   13.63221  -5.99672  1.000 11.73560 ? 141 SER A CB  1 
ATOM   982  O OG  . SER A 1 130 ? 2.91481   14.71689  -5.46406  1.000 12.73621 ? 141 SER A OG  1 
ATOM   983  N N   . VAL A 1 131 ? 0.56250   14.03711  -2.90670  1.000 8.20854  ? 142 VAL A N   1 
ATOM   984  C CA  . VAL A 1 131 ? -0.34093  14.84052  -2.09207  1.000 8.51402  ? 142 VAL A CA  1 
ATOM   985  C C   . VAL A 1 131 ? 0.44977   15.92850  -1.36260  1.000 9.15137  ? 142 VAL A C   1 
ATOM   986  O O   . VAL A 1 131 ? 1.67607   15.89834  -1.30081  1.000 9.96486  ? 142 VAL A O   1 
ATOM   987  C CB  . VAL A 1 131 ? -1.16963  13.98748  -1.10755  1.000 11.18261 ? 142 VAL A CB  1 
ATOM   988  C CG1 . VAL A 1 131 ? -1.92078  12.87424  -1.85466  1.000 14.09311 ? 142 VAL A CG1 1 
ATOM   989  C CG2 . VAL A 1 131 ? -0.28314  13.39200  -0.00663  1.000 9.38782  ? 142 VAL A CG2 1 
ATOM   990  N N   . THR A 1 132 ? -0.27346  16.90389  -0.81180  1.000 10.60190 ? 143 THR A N   1 
ATOM   991  C CA  . THR A 1 132 ? 0.38959   17.98706  -0.09829  1.000 10.46099 ? 143 THR A CA  1 
ATOM   992  C C   . THR A 1 132 ? 1.13306   17.44209  1.12043   1.000 10.75616 ? 143 THR A C   1 
ATOM   993  O O   . THR A 1 132 ? 0.53730   16.75019  1.95498   1.000 10.99825 ? 143 THR A O   1 
ATOM   994  C CB  . THR A 1 132 ? -0.62475  19.03595  0.34255   1.000 12.71144 ? 143 THR A CB  1 
ATOM   995  O OG1 . THR A 1 132 ? -1.29700  19.54038  -0.82212  1.000 15.38125 ? 143 THR A OG1 1 
ATOM   996  C CG2 . THR A 1 132 ? 0.08384   20.19076  1.06786   1.000 13.29606 ? 143 THR A CG2 1 
ATOM   997  N N   . PRO A 1 133 ? 2.42352   17.70924  1.24920   1.000 7.55729  ? 144 PRO A N   1 
ATOM   998  C CA  . PRO A 1 133 ? 3.16256   17.19638  2.40916   1.000 7.79730  ? 144 PRO A CA  1 
ATOM   999  C C   . PRO A 1 133 ? 2.72233   17.83972  3.71847   1.000 7.70072  ? 144 PRO A C   1 
ATOM   1000 O O   . PRO A 1 133 ? 2.26207   18.98301  3.75750   1.000 9.00505  ? 144 PRO A O   1 
ATOM   1001 C CB  . PRO A 1 133 ? 4.62022   17.53951  2.07681   1.000 8.45024  ? 144 PRO A CB  1 
ATOM   1002 C CG  . PRO A 1 133 ? 4.65634   17.67980  0.57938   1.000 8.17244  ? 144 PRO A CG  1 
ATOM   1003 C CD  . PRO A 1 133 ? 3.31104   18.28976  0.22747   1.000 8.20031  ? 144 PRO A CD  1 
ATOM   1004 N N   . THR A 1 134 ? 2.86108   17.07137  4.80171   1.000 5.55665  ? 145 THR A N   1 
ATOM   1005 C CA  . THR A 1 134 ? 2.51030   17.54188  6.14719   1.000 7.17101  ? 145 THR A CA  1 
ATOM   1006 C C   . THR A 1 134 ? 3.25207   18.82911  6.51174   1.000 7.03876  ? 145 THR A C   1 
ATOM   1007 O O   . THR A 1 134 ? 4.46356   18.94180  6.31597   1.000 7.69295  ? 145 THR A O   1 
ATOM   1008 C CB  . THR A 1 134 ? 2.81874   16.42379  7.15433   1.000 6.49793  ? 145 THR A CB  1 
ATOM   1009 O OG1 . THR A 1 134 ? 2.07607   15.25529  6.76914   1.000 8.98204  ? 145 THR A OG1 1 
ATOM   1010 C CG2 . THR A 1 134 ? 2.40976   16.82909  8.58117   1.000 9.03676  ? 145 THR A CG2 1 
ATOM   1011 N N   . ASP A 1 135 ? 2.52258   19.80757  7.06808   1.000 7.23567  ? 146 ASP A N   1 
ATOM   1012 C CA  . ASP A 1 135 ? 3.05981   21.15177  7.30477   1.000 8.17909  ? 146 ASP A CA  1 
ATOM   1013 C C   . ASP A 1 135 ? 3.80494   21.19514  8.64369   1.000 8.81548  ? 146 ASP A C   1 
ATOM   1014 O O   . ASP A 1 135 ? 3.18319   21.12730  9.71329   1.000 7.93415  ? 146 ASP A O   1 
ATOM   1015 C CB  . ASP A 1 135 ? 1.89744   22.14182  7.26846   1.000 9.29939  ? 146 ASP A CB  1 
ATOM   1016 C CG  . ASP A 1 135 ? 2.32440   23.59437  7.41604   1.000 11.85459 ? 146 ASP A CG  1 
ATOM   1017 O OD1 . ASP A 1 135 ? 3.43351   23.89240  7.90865   1.000 11.49266 ? 146 ASP A OD1 1 
ATOM   1018 O OD2 . ASP A 1 135 ? 1.54269   24.47417  6.97226   1.000 16.35483 ? 146 ASP A OD2 1 
ATOM   1019 N N   . PHE A 1 136 ? 5.14319   21.32984  8.58801   1.000 8.92009  ? 147 PHE A N   1 
ATOM   1020 C CA  . PHE A 1 136 ? 5.96093   21.35389  9.80408   1.000 7.82834  ? 147 PHE A CA  1 
ATOM   1021 C C   . PHE A 1 136 ? 5.57048   22.49015  10.74716  1.000 8.76106  ? 147 PHE A C   1 
ATOM   1022 O O   . PHE A 1 136 ? 5.79489   22.38544  11.96109  1.000 10.48357 ? 147 PHE A O   1 
ATOM   1023 C CB  . PHE A 1 136 ? 7.44138   21.53147  9.44389   1.000 7.30839  ? 147 PHE A CB  1 
ATOM   1024 C CG  . PHE A 1 136 ? 8.12874   20.27850  8.96479   1.000 6.99857  ? 147 PHE A CG  1 
ATOM   1025 C CD1 . PHE A 1 136 ? 8.31938   19.20329  9.81637   1.000 9.11366  ? 147 PHE A CD1 1 
ATOM   1026 C CD2 . PHE A 1 136 ? 8.62435   20.19706  7.66889   1.000 7.35072  ? 147 PHE A CD2 1 
ATOM   1027 C CE1 . PHE A 1 136 ? 8.97476   18.05140  9.37338   1.000 10.39480 ? 147 PHE A CE1 1 
ATOM   1028 C CE2 . PHE A 1 136 ? 9.28651   19.03718  7.22221   1.000 7.24341  ? 147 PHE A CE2 1 
ATOM   1029 C CZ  . PHE A 1 136 ? 9.46051   17.97647  8.07389   1.000 10.37987 ? 147 PHE A CZ  1 
ATOM   1030 N N   . SER A 1 137 ? 5.01957   23.58333  10.21336  1.000 9.83392  ? 148 SER A N   1 
ATOM   1031 C CA  . SER A 1 137 ? 4.70746   24.74369  11.04689  1.000 8.43484  ? 148 SER A CA  1 
ATOM   1032 C C   . SER A 1 137 ? 3.49996   24.51903  11.93697  1.000 9.91248  ? 148 SER A C   1 
ATOM   1033 O O   . SER A 1 137 ? 3.28314   25.31948  12.85935  1.000 12.11458 ? 148 SER A O   1 
ATOM   1034 C CB  . SER A 1 137 ? 4.51897   26.00996  10.20307  1.000 8.66806  ? 148 SER A CB  1 
ATOM   1035 O OG  . SER A 1 137 ? 3.28875   26.00088  9.49756   1.000 12.73523 ? 148 SER A OG  1 
ATOM   1036 N N   . MET A 1 138 ? 2.72283   23.46015  11.69965  1.000 8.81355  ? 149 MET A N   1 
ATOM   1037 C CA  . MET A 1 138 ? 1.53621   23.18898  12.50540  1.000 10.86793 ? 149 MET A CA  1 
ATOM   1038 C C   . MET A 1 138 ? 1.76819   22.32630  13.74270  1.000 12.66687 ? 149 MET A C   1 
ATOM   1039 O O   . MET A 1 138 ? 0.84357   22.20233  14.55337  1.000 12.12017 ? 149 MET A O   1 
ATOM   1040 C CB  . MET A 1 138 ? 0.36733   22.62624  11.67319  1.000 12.32657 ? 149 MET A CB  1 
ATOM   1041 C CG  . MET A 1 138 ? -0.03336  23.45705  10.47177  1.000 14.07827 ? 149 MET A CG  1 
ATOM   1042 S SD  . MET A 1 138 ? -1.08275  22.58107  9.27399   1.000 23.91288 ? 149 MET A SD  1 
ATOM   1043 C CE  . MET A 1 138 ? -2.22166  21.71799  10.32737  1.000 18.95309 ? 149 MET A CE  1 
ATOM   1044 N N   . TYR A 1 139 ? 2.96754   21.76807  13.95634  1.000 9.88694  ? 150 TYR A N   1 
ATOM   1045 C CA  . TYR A 1 139 ? 3.13630   20.74568  14.98245  1.000 7.81640  ? 150 TYR A CA  1 
ATOM   1046 C C   . TYR A 1 139 ? 4.43852   20.93446  15.75452  1.000 11.07815 ? 150 TYR A C   1 
ATOM   1047 O O   . TYR A 1 139 ? 5.44423   21.38533  15.20596  1.000 14.09922 ? 150 TYR A O   1 
ATOM   1048 C CB  . TYR A 1 139 ? 3.13497   19.34577  14.34023  1.000 8.29087  ? 150 TYR A CB  1 
ATOM   1049 C CG  . TYR A 1 139 ? 1.87216   19.05846  13.56470  1.000 7.74211  ? 150 TYR A CG  1 
ATOM   1050 C CD1 . TYR A 1 139 ? 0.65866   18.87022  14.22761  1.000 11.44681 ? 150 TYR A CD1 1 
ATOM   1051 C CD2 . TYR A 1 139 ? 1.88598   19.02609  12.18156  1.000 7.63563  ? 150 TYR A CD2 1 
ATOM   1052 C CE1 . TYR A 1 139 ? -0.49579  18.63977  13.53025  1.000 10.86679 ? 150 TYR A CE1 1 
ATOM   1053 C CE2 . TYR A 1 139 ? 0.73493   18.78636  11.46268  1.000 11.85672 ? 150 TYR A CE2 1 
ATOM   1054 C CZ  . TYR A 1 139 ? -0.45221  18.59516  12.14339  1.000 12.54381 ? 150 TYR A CZ  1 
ATOM   1055 O OH  . TYR A 1 139 ? -1.60197  18.35250  11.41589  1.000 16.08212 ? 150 TYR A OH  1 
ATOM   1056 N N   . ASP A 1 140 ? 4.40733   20.57275  17.04189  1.000 12.15396 ? 151 ASP A N   1 
ATOM   1057 C CA  . ASP A 1 140 ? 5.60639   20.58941  17.87143  1.000 11.74523 ? 151 ASP A CA  1 
ATOM   1058 C C   . ASP A 1 140 ? 6.59324   19.51080  17.41446  1.000 12.15115 ? 151 ASP A C   1 
ATOM   1059 O O   . ASP A 1 140 ? 6.18381   18.41377  17.01631  1.000 12.04380 ? 151 ASP A O   1 
ATOM   1060 C CB  . ASP A 1 140 ? 5.22483   20.31996  19.32746  1.000 13.68010 ? 151 ASP A CB  1 
ATOM   1061 C CG  . ASP A 1 140 ? 6.36087   20.61438  20.28071  1.000 25.78434 ? 151 ASP A CG  1 
ATOM   1062 O OD1 . ASP A 1 140 ? 6.54505   21.80308  20.62726  1.000 27.72309 ? 151 ASP A OD1 1 
ATOM   1063 O OD2 . ASP A 1 140 ? 7.09211   19.67217  20.65840  1.000 23.06850 ? 151 ASP A OD2 1 
ATOM   1064 N N   . PRO A 1 141 ? 7.90050   19.77953  17.47808  1.000 12.14553 ? 152 PRO A N   1 
ATOM   1065 C CA  . PRO A 1 141 ? 8.88744   18.74199  17.12138  1.000 12.35577 ? 152 PRO A CA  1 
ATOM   1066 C C   . PRO A 1 141 ? 8.79817   17.46758  17.94375  1.000 14.79485 ? 152 PRO A C   1 
ATOM   1067 O O   . PRO A 1 141 ? 9.30877   16.43107  17.49499  1.000 16.30333 ? 152 PRO A O   1 
ATOM   1068 C CB  . PRO A 1 141 ? 10.23425  19.44940  17.33392  1.000 17.01546 ? 152 PRO A CB  1 
ATOM   1069 C CG  . PRO A 1 141 ? 9.92150   20.89568  17.11902  1.000 19.24266 ? 152 PRO A CG  1 
ATOM   1070 C CD  . PRO A 1 141 ? 8.54494   21.08237  17.72996  1.000 17.25373 ? 152 PRO A CD  1 
ATOM   1071 N N   . SER A 1 142 ? 8.18714   17.49533  19.12810  1.000 12.37945 ? 153 SER A N   1 
ATOM   1072 C CA  . SER A 1 142 ? 8.03579   16.29643  19.94682  1.000 12.83550 ? 153 SER A CA  1 
ATOM   1073 C C   . SER A 1 142 ? 6.80038   15.47623  19.58387  1.000 13.39304 ? 153 SER A C   1 
ATOM   1074 O O   . SER A 1 142 ? 6.56628   14.42385  20.19203  1.000 13.95312 ? 153 SER A O   1 
ATOM   1075 C CB  . SER A 1 142 ? 7.96915   16.68741  21.42790  1.000 17.99422 ? 153 SER A CB  1 
ATOM   1076 O OG  . SER A 1 142 ? 6.78515   17.43124  21.68713  1.000 19.12188 ? 153 SER A OG  1 
ATOM   1077 N N   . ASP A 1 143 ? 6.00306   15.92867  18.61594  1.000 11.23292 ? 154 ASP A N   1 
ATOM   1078 C CA  . ASP A 1 143 ? 4.73004   15.28830  18.27097  1.000 11.19184 ? 154 ASP A CA  1 
ATOM   1079 C C   . ASP A 1 143 ? 5.02821   14.17560  17.27414  1.000 10.68597 ? 154 ASP A C   1 
ATOM   1080 O O   . ASP A 1 143 ? 4.99782   14.38170  16.05926  1.000 10.72854 ? 154 ASP A O   1 
ATOM   1081 C CB  . ASP A 1 143 ? 3.78330   16.33896  17.70153  1.000 11.94033 ? 154 ASP A CB  1 
ATOM   1082 C CG  . ASP A 1 143 ? 2.40210   15.79524  17.37774  1.000 13.55410 ? 154 ASP A CG  1 
ATOM   1083 O OD1 . ASP A 1 143 ? 2.17264   14.57378  17.49699  1.000 16.31283 ? 154 ASP A OD1 1 
ATOM   1084 O OD2 . ASP A 1 143 ? 1.53519   16.61026  16.99299  1.000 13.47070 ? 154 ASP A OD2 1 
ATOM   1085 N N   . VAL A 1 144 ? 5.31602   12.97656  17.79963  1.000 10.37220 ? 155 VAL A N   1 
ATOM   1086 C CA  . VAL A 1 144 ? 5.71323   11.84258  16.95551  1.000 11.12837 ? 155 VAL A CA  1 
ATOM   1087 C C   . VAL A 1 144 ? 4.62520   11.49818  15.94480  1.000 8.67837  ? 155 VAL A C   1 
ATOM   1088 O O   . VAL A 1 144 ? 4.90755   11.18527  14.77706  1.000 8.65821  ? 155 VAL A O   1 
ATOM   1089 C CB  . VAL A 1 144 ? 6.06324   10.62613  17.83584  1.000 10.80905 ? 155 VAL A CB  1 
ATOM   1090 C CG1 . VAL A 1 144 ? 6.24345   9.37750   16.97547  1.000 12.66998 ? 155 VAL A CG1 1 
ATOM   1091 C CG2 . VAL A 1 144 ? 7.30607   10.90093  18.67819  1.000 12.27648 ? 155 VAL A CG2 1 
ATOM   1092 N N   . GLU A 1 145 ? 3.36857   11.52711  16.37863  1.000 9.41669  ? 156 GLU A N   1 
ATOM   1093 C CA  . GLU A 1 145 ? 2.25718   11.09547  15.54531  1.000 9.60110  ? 156 GLU A CA  1 
ATOM   1094 C C   . GLU A 1 145 ? 1.99606   12.01261  14.36171  1.000 8.99863  ? 156 GLU A C   1 
ATOM   1095 O O   . GLU A 1 145 ? 1.23837   11.62392  13.46266  1.000 8.88371  ? 156 GLU A O   1 
ATOM   1096 C CB  . GLU A 1 145 ? 0.98562   10.91675  16.38461  1.000 10.81565 ? 156 GLU A CB  1 
ATOM   1097 C CG  . GLU A 1 145 ? 1.07848   9.78897   17.43471  1.000 13.10990 ? 156 GLU A CG  1 
ATOM   1098 C CD  . GLU A 1 145 ? 2.00009   10.07205  18.61486  1.000 27.14195 ? 156 GLU A CD  1 
ATOM   1099 O OE1 . GLU A 1 145 ? 2.18691   11.25722  18.99435  1.000 23.70309 ? 156 GLU A OE1 1 
ATOM   1100 O OE2 . GLU A 1 145 ? 2.55025   9.08343   19.15921  1.000 34.37473 ? 156 GLU A OE2 1 
ATOM   1101 N N   . HIS A 1 146 ? 2.58174   13.21237  14.33911  1.000 8.32535  ? 157 HIS A N   1 
ATOM   1102 C CA  . HIS A 1 146 ? 2.47329   14.07477  13.16709  1.000 8.36949  ? 157 HIS A CA  1 
ATOM   1103 C C   . HIS A 1 146 ? 3.78695   14.30337  12.42927  1.000 6.99276  ? 157 HIS A C   1 
ATOM   1104 O O   . HIS A 1 146 ? 3.76020   14.40462  11.19841  1.000 7.31596  ? 157 HIS A O   1 
ATOM   1105 C CB  . HIS A 1 146 ? 1.84844   15.42780  13.54559  1.000 8.93734  ? 157 HIS A CB  1 
ATOM   1106 C CG  . HIS A 1 146 ? 0.38439   15.34677  13.86648  1.000 7.05678  ? 157 HIS A CG  1 
ATOM   1107 N ND1 . HIS A 1 146 ? -0.10368  15.52952  15.14343  1.000 11.18938 ? 157 HIS A ND1 1 
ATOM   1108 C CD2 . HIS A 1 146 ? -0.69469  15.11748  13.07961  1.000 10.33667 ? 157 HIS A CD2 1 
ATOM   1109 C CE1 . HIS A 1 146 ? -1.41987  15.41034  15.13042  1.000 11.61004 ? 157 HIS A CE1 1 
ATOM   1110 N NE2 . HIS A 1 146 ? -1.80404  15.16724  13.89037  1.000 12.10798 ? 157 HIS A NE2 1 
ATOM   1111 N N   . VAL A 1 147 ? 4.93162   14.35706  13.12895  1.000 7.20340  ? 158 VAL A N   1 
ATOM   1112 C CA  . VAL A 1 147 ? 6.19610   14.73769  12.49336  1.000 7.45133  ? 158 VAL A CA  1 
ATOM   1113 C C   . VAL A 1 147 ? 7.37186   13.87091  12.93984  1.000 6.43313  ? 158 VAL A C   1 
ATOM   1114 O O   . VAL A 1 147 ? 8.52955   14.21304  12.67747  1.000 7.43645  ? 158 VAL A O   1 
ATOM   1115 C CB  . VAL A 1 147 ? 6.49531   16.24318  12.68777  1.000 6.13453  ? 158 VAL A CB  1 
ATOM   1116 C CG1 . VAL A 1 147 ? 5.54240   17.10005  11.84332  1.000 8.70090  ? 158 VAL A CG1 1 
ATOM   1117 C CG2 . VAL A 1 147 ? 6.42905   16.62788  14.15708  1.000 7.74750  ? 158 VAL A CG2 1 
ATOM   1118 N N   . GLY A 1 148 ? 7.09913   12.72592  13.57815  1.000 7.05981  ? 159 GLY A N   1 
ATOM   1119 C CA  . GLY A 1 148 ? 8.18545   11.90891  14.11146  1.000 8.38831  ? 159 GLY A CA  1 
ATOM   1120 C C   . GLY A 1 148 ? 9.13800   11.36798  13.05854  1.000 7.45074  ? 159 GLY A C   1 
ATOM   1121 O O   . GLY A 1 148 ? 10.32740  11.15028  13.33968  1.000 7.21315  ? 159 GLY A O   1 
ATOM   1122 N N   . TRP A 1 149 ? 8.63487   11.12480  11.84603  1.000 6.06830  ? 160 TRP A N   1 
ATOM   1123 C CA  . TRP A 1 149 ? 9.42493   10.63223  10.72104  1.000 5.78022  ? 160 TRP A CA  1 
ATOM   1124 C C   . TRP A 1 149 ? 10.47484  11.62320  10.25140  1.000 6.43189  ? 160 TRP A C   1 
ATOM   1125 O O   . TRP A 1 149 ? 11.36520  11.23170  9.49681   1.000 7.37650  ? 160 TRP A O   1 
ATOM   1126 C CB  . TRP A 1 149 ? 8.49124   10.21630  9.57117   1.000 7.16396  ? 160 TRP A CB  1 
ATOM   1127 C CG  . TRP A 1 149 ? 7.40139   11.20130  9.47627   1.000 7.99538  ? 160 TRP A CG  1 
ATOM   1128 C CD1 . TRP A 1 149 ? 6.15997   11.08478  10.01714  1.000 6.38574  ? 160 TRP A CD1 1 
ATOM   1129 C CD2 . TRP A 1 149 ? 7.46468   12.50134  8.87913   1.000 6.57380  ? 160 TRP A CD2 1 
ATOM   1130 N NE1 . TRP A 1 149 ? 5.44499   12.23619  9.80533   1.000 7.95472  ? 160 TRP A NE1 1 
ATOM   1131 C CE2 . TRP A 1 149 ? 6.21278   13.11593  9.08950   1.000 6.43883  ? 160 TRP A CE2 1 
ATOM   1132 C CE3 . TRP A 1 149 ? 8.44951   13.20325  8.16338   1.000 7.07377  ? 160 TRP A CE3 1 
ATOM   1133 C CZ2 . TRP A 1 149 ? 5.92632   14.40791  8.64032   1.000 8.76496  ? 160 TRP A CZ2 1 
ATOM   1134 C CZ3 . TRP A 1 149 ? 8.16322   14.50136  7.72026   1.000 7.70908  ? 160 TRP A CZ3 1 
ATOM   1135 C CH2 . TRP A 1 149 ? 6.91225   15.08015  7.96104   1.000 8.02417  ? 160 TRP A CH2 1 
ATOM   1136 N N   . TYR A 1 150 ? 10.40362  12.88403  10.67886  1.000 6.62544  ? 161 TYR A N   1 
ATOM   1137 C CA  . TYR A 1 150 ? 11.50156  13.82552  10.46774  1.000 7.00822  ? 161 TYR A CA  1 
ATOM   1138 C C   . TYR A 1 150 ? 12.41495  13.89192  11.68771  1.000 8.43715  ? 161 TYR A C   1 
ATOM   1139 O O   . TYR A 1 150 ? 13.62124  13.64593  11.58049  1.000 7.09042  ? 161 TYR A O   1 
ATOM   1140 C CB  . TYR A 1 150 ? 10.98647  15.23918  10.12158  1.000 8.18569  ? 161 TYR A CB  1 
ATOM   1141 C CG  . TYR A 1 150 ? 12.13366  16.22569  9.93787   1.000 8.38437  ? 161 TYR A CG  1 
ATOM   1142 C CD1 . TYR A 1 150 ? 12.81435  16.32697  8.72456   1.000 9.59296  ? 161 TYR A CD1 1 
ATOM   1143 C CD2 . TYR A 1 150 ? 12.57310  17.00495  11.00113  1.000 9.61315  ? 161 TYR A CD2 1 
ATOM   1144 C CE1 . TYR A 1 150 ? 13.90068  17.20330  8.58027   1.000 7.01800  ? 161 TYR A CE1 1 
ATOM   1145 C CE2 . TYR A 1 150 ? 13.63986  17.87738  10.87291  1.000 9.20458  ? 161 TYR A CE2 1 
ATOM   1146 C CZ  . TYR A 1 150 ? 14.30209  17.97315  9.66624   1.000 8.84337  ? 161 TYR A CZ  1 
ATOM   1147 O OH  . TYR A 1 150 ? 15.35615  18.84381  9.58278   1.000 11.55647 ? 161 TYR A OH  1 
ATOM   1148 N N   . TYR A 1 151 ? 11.86460  14.23125  12.85715  1.000 7.08556  ? 162 TYR A N   1 
ATOM   1149 C CA  . TYR A 1 151 ? 12.72591  14.56373  13.99590  1.000 7.16875  ? 162 TYR A CA  1 
ATOM   1150 C C   . TYR A 1 151 ? 13.48585  13.35611  14.54822  1.000 8.25840  ? 162 TYR A C   1 
ATOM   1151 O O   . TYR A 1 151 ? 14.65580  13.48441  14.91975  1.000 9.85069  ? 162 TYR A O   1 
ATOM   1152 C CB  . TYR A 1 151 ? 11.94073  15.29589  15.08400  1.000 7.69593  ? 162 TYR A CB  1 
ATOM   1153 C CG  . TYR A 1 151 ? 11.48501  16.66495  14.61197  1.000 8.69151  ? 162 TYR A CG  1 
ATOM   1154 C CD1 . TYR A 1 151 ? 12.35517  17.74784  14.61963  1.000 11.13270 ? 162 TYR A CD1 1 
ATOM   1155 C CD2 . TYR A 1 151 ? 10.19560  16.85877  14.12626  1.000 8.48587  ? 162 TYR A CD2 1 
ATOM   1156 C CE1 . TYR A 1 151 ? 11.94432  18.99569  14.16809  1.000 10.53976 ? 162 TYR A CE1 1 
ATOM   1157 C CE2 . TYR A 1 151 ? 9.78044   18.09598  13.67108  1.000 10.45480 ? 162 TYR A CE2 1 
ATOM   1158 C CZ  . TYR A 1 151 ? 10.64737  19.15761  13.69900  1.000 11.11533 ? 162 TYR A CZ  1 
ATOM   1159 O OH  . TYR A 1 151 ? 10.18661  20.38553  13.24770  1.000 13.99945 ? 162 TYR A OH  1 
ATOM   1160 N N   . ILE A 1 152 ? 12.86651  12.18105  14.60270  1.000 7.39222  ? 163 ILE A N   1 
ATOM   1161 C CA  . ILE A 1 152 ? 13.57511  11.02421  15.15686  1.000 8.76896  ? 163 ILE A CA  1 
ATOM   1162 C C   . ILE A 1 152 ? 14.76524  10.61582  14.28491  1.000 8.37366  ? 163 ILE A C   1 
ATOM   1163 O O   . ILE A 1 152 ? 15.88989  10.49280  14.79942  1.000 8.54617  ? 163 ILE A O   1 
ATOM   1164 C CB  . ILE A 1 152 ? 12.61228  9.88470   15.53157  1.000 8.17198  ? 163 ILE A CB  1 
ATOM   1165 C CG1 . ILE A 1 152 ? 11.79664  10.30727  16.76783  1.000 9.80562  ? 163 ILE A CG1 1 
ATOM   1166 C CG2 . ILE A 1 152 ? 13.37646  8.59208   15.80584  1.000 10.76849 ? 163 ILE A CG2 1 
ATOM   1167 C CD1 . ILE A 1 152 ? 10.58872  9.43516   17.02537  1.000 14.82894 ? 163 ILE A CD1 1 
ATOM   1168 N N   . PRO A 1 153 ? 14.60320  10.42513  12.97130  1.000 6.41503  ? 164 PRO A N   1 
ATOM   1169 C CA  . PRO A 1 153 ? 15.78631  10.09233  12.15773  1.000 7.31989  ? 164 PRO A CA  1 
ATOM   1170 C C   . PRO A 1 153 ? 16.85075  11.17412  12.15241  1.000 8.29892  ? 164 PRO A C   1 
ATOM   1171 O O   . PRO A 1 153 ? 18.04223  10.85416  12.22041  1.000 9.68363  ? 164 PRO A O   1 
ATOM   1172 C CB  . PRO A 1 153 ? 15.19421  9.84836   10.76212  1.000 8.56223  ? 164 PRO A CB  1 
ATOM   1173 C CG  . PRO A 1 153 ? 13.76170  9.43040   11.04630  1.000 6.82442  ? 164 PRO A CG  1 
ATOM   1174 C CD  . PRO A 1 153 ? 13.35145  10.29146  12.20263  1.000 6.31092  ? 164 PRO A CD  1 
ATOM   1175 N N   . VAL A 1 154 ? 16.46619  12.44948  12.07472  1.000 7.55046  ? 165 VAL A N   1 
ATOM   1176 C CA  . VAL A 1 154 ? 17.46730  13.51713  12.03233  1.000 8.15473  ? 165 VAL A CA  1 
ATOM   1177 C C   . VAL A 1 154 ? 18.23927  13.59630  13.34999  1.000 9.95979  ? 165 VAL A C   1 
ATOM   1178 O O   . VAL A 1 154 ? 19.46493  13.76988  13.36397  1.000 11.77593 ? 165 VAL A O   1 
ATOM   1179 C CB  . VAL A 1 154 ? 16.79580  14.84007  11.63127  1.000 12.08937 ? 165 VAL A CB  1 
ATOM   1180 C CG1 . VAL A 1 154 ? 17.74629  16.00682  11.83822  1.000 17.56453 ? 165 VAL A CG1 1 
ATOM   1181 C CG2 . VAL A 1 154 ? 16.34373  14.75733  10.16655  1.000 9.81320  ? 165 VAL A CG2 1 
ATOM   1182 N N   . GLN A 1 155 ? 17.55141  13.39721  14.47518  1.000 8.48972  ? 166 GLN A N   1 
ATOM   1183 C CA  . GLN A 1 155 ? 18.23137  13.36105  15.76446  1.000 9.67404  ? 166 GLN A CA  1 
ATOM   1184 C C   . GLN A 1 155 ? 19.13293  12.13850  15.90221  1.000 11.81396 ? 166 GLN A C   1 
ATOM   1185 O O   . GLN A 1 155 ? 20.14764  12.19622  16.60403  1.000 16.05326 ? 166 GLN A O   1 
ATOM   1186 C CB  . GLN A 1 155 ? 17.19498  13.44001  16.88974  1.000 11.17220 ? 166 GLN A CB  1 
ATOM   1187 C CG  . GLN A 1 155 ? 16.56149  14.82406  16.93399  1.000 11.76289 ? 166 GLN A CG  1 
ATOM   1188 C CD  . GLN A 1 155 ? 15.32315  14.92787  17.80455  1.000 14.88883 ? 166 GLN A CD  1 
ATOM   1189 O OE1 . GLN A 1 155 ? 14.97282  13.99996  18.53698  1.000 21.32521 ? 166 GLN A OE1 1 
ATOM   1190 N NE2 . GLN A 1 155 ? 14.66647  16.08369  17.74198  1.000 17.62027 ? 166 GLN A NE2 1 
ATOM   1191 N N   . ASN A 1 156 ? 18.77408  11.02697  15.25649  1.000 10.77947 ? 167 ASN A N   1 
ATOM   1192 C CA  A ASN A 1 156 ? 19.63396  9.84930   15.27037  0.499 11.84408 ? 167 ASN A CA  1 
ATOM   1193 C CA  B ASN A 1 156 ? 19.62387  9.83916   15.26289  0.501 11.85459 ? 167 ASN A CA  1 
ATOM   1194 C C   . ASN A 1 156 ? 20.89902  10.07546  14.45878  1.000 13.43011 ? 167 ASN A C   1 
ATOM   1195 O O   . ASN A 1 156 ? 21.95390  9.52092   14.78876  1.000 16.72781 ? 167 ASN A O   1 
ATOM   1196 C CB  A ASN A 1 156 ? 18.88505  8.65103   14.69440  0.499 11.66653 ? 167 ASN A CB  1 
ATOM   1197 C CB  B ASN A 1 156 ? 18.82649  8.65107   14.69696  0.501 11.65146 ? 167 ASN A CB  1 
ATOM   1198 C CG  A ASN A 1 156 ? 17.91139  8.05828   15.66694  0.499 10.19415 ? 167 ASN A CG  1 
ATOM   1199 C CG  B ASN A 1 156 ? 19.35097  7.28732   15.15654  0.501 13.41085 ? 167 ASN A CG  1 
ATOM   1200 O OD1 A ASN A 1 156 ? 17.89214  8.42342   16.84719  0.499 15.43277 ? 167 ASN A OD1 1 
ATOM   1201 O OD1 B ASN A 1 156 ? 19.80451  7.12378   16.29013  0.501 17.08943 ? 167 ASN A OD1 1 
ATOM   1202 N ND2 A ASN A 1 156 ? 17.08978  7.13260   15.18751  0.499 13.02805 ? 167 ASN A ND2 1 
ATOM   1203 N ND2 B ASN A 1 156 ? 19.25988  6.29571   14.27388  0.501 17.01885 ? 167 ASN A ND2 1 
ATOM   1204 N N   . GLY A 1 157 ? 20.81590  10.87978  13.40181  1.000 11.15612 ? 168 GLY A N   1 
ATOM   1205 C CA  . GLY A 1 157 ? 21.97174  11.19169  12.58904  1.000 14.43213 ? 168 GLY A CA  1 
ATOM   1206 C C   . GLY A 1 157 ? 22.41807  10.09574  11.65708  1.000 17.46737 ? 168 GLY A C   1 
ATOM   1207 O O   . GLY A 1 157 ? 23.55472  10.13044  11.17998  1.000 20.68000 ? 168 GLY A O   1 
ATOM   1208 N N   . LYS A 1 158 ? 21.56001  9.11343   11.38926  1.000 10.34878 ? 169 LYS A N   1 
ATOM   1209 C CA  . LYS A 1 158 ? 21.88111  8.03017   10.46743  1.000 12.16363 ? 169 LYS A CA  1 
ATOM   1210 C C   . LYS A 1 158 ? 20.57115  7.39901   10.02186  1.000 9.31199  ? 169 LYS A C   1 
ATOM   1211 O O   . LYS A 1 158 ? 19.50217  7.73042   10.53453  1.000 10.03399 ? 169 LYS A O   1 
ATOM   1212 C CB  . LYS A 1 158 ? 22.78597  6.96694   11.10638  1.000 15.93018 ? 169 LYS A CB  1 
ATOM   1213 C CG  . LYS A 1 158 ? 22.26025  6.39083   12.40945  1.000 19.68303 ? 169 LYS A CG  1 
ATOM   1214 C CD  . LYS A 1 158 ? 23.39104  5.76603   13.21764  1.000 27.91850 ? 169 LYS A CD  1 
ATOM   1215 C CE  . LYS A 1 158 ? 22.94382  5.38561   14.61760  1.000 34.93996 ? 169 LYS A CE  1 
ATOM   1216 N NZ  . LYS A 1 158 ? 23.48614  6.32989   15.64240  1.000 45.76415 ? 169 LYS A NZ  1 
ATOM   1217 N N   . GLU A 1 159 ? 20.67627  6.45663   9.08954   1.000 8.00244  ? 170 GLU A N   1 
ATOM   1218 C CA  . GLU A 1 159 ? 19.51504  5.67094   8.68134   1.000 8.35193  ? 170 GLU A CA  1 
ATOM   1219 C C   . GLU A 1 159 ? 18.83520  5.04945   9.89335   1.000 8.97639  ? 170 GLU A C   1 
ATOM   1220 O O   . GLU A 1 159 ? 19.49803  4.53297   10.79932  1.000 11.82045 ? 170 GLU A O   1 
ATOM   1221 C CB  . GLU A 1 159 ? 19.93702  4.58995   7.67365   1.000 10.68449 ? 170 GLU A CB  1 
ATOM   1222 C CG  . GLU A 1 159 ? 20.85721  3.48467   8.22679   1.000 11.79686 ? 170 GLU A CG  1 
ATOM   1223 C CD  . GLU A 1 159 ? 22.29297  3.94055   8.52146   1.000 19.62400 ? 170 GLU A CD  1 
ATOM   1224 O OE1 . GLU A 1 159 ? 22.76795  4.97652   7.98246   1.000 17.40639 ? 170 GLU A OE1 1 
ATOM   1225 O OE2 . GLU A 1 159 ? 22.95530  3.24706   9.32138   1.000 31.48828 ? 170 GLU A OE2 1 
ATOM   1226 N N   . THR A 1 160 ? 17.50184  5.09699   9.88770   1.000 6.70027  ? 171 THR A N   1 
ATOM   1227 C CA  . THR A 1 160 ? 16.68545  4.81465   11.06568  1.000 6.29362  ? 171 THR A CA  1 
ATOM   1228 C C   . THR A 1 160 ? 15.46816  3.98964   10.67870  1.000 9.62575  ? 171 THR A C   1 
ATOM   1229 O O   . THR A 1 160 ? 14.68317  4.40222   9.82005   1.000 7.79465  ? 171 THR A O   1 
ATOM   1230 C CB  . THR A 1 160 ? 16.20060  6.13487   11.66086  1.000 7.15763  ? 171 THR A CB  1 
ATOM   1231 O OG1 . THR A 1 160 ? 17.33688  6.90785   12.07621  1.000 9.66284  ? 171 THR A OG1 1 
ATOM   1232 C CG2 . THR A 1 160 ? 15.26562  5.88104   12.85487  1.000 9.97584  ? 171 THR A CG2 1 
ATOM   1233 N N   . TRP A 1 161 ? 15.30867  2.83435   11.32215  1.000 7.89061  ? 172 TRP A N   1 
ATOM   1234 C CA  . TRP A 1 161 ? 14.03885  2.12822   11.36471  1.000 7.16444  ? 172 TRP A CA  1 
ATOM   1235 C C   . TRP A 1 161 ? 13.26097  2.63591   12.57577  1.000 8.35809  ? 172 TRP A C   1 
ATOM   1236 O O   . TRP A 1 161 ? 13.73246  2.53648   13.71889  1.000 12.22232 ? 172 TRP A O   1 
ATOM   1237 C CB  . TRP A 1 161 ? 14.27543  0.62229   11.49391  1.000 7.45999  ? 172 TRP A CB  1 
ATOM   1238 C CG  . TRP A 1 161 ? 14.53268  -0.07272  10.16517  1.000 6.87002  ? 172 TRP A CG  1 
ATOM   1239 C CD1 . TRP A 1 161 ? 15.74445  -0.51040  9.67254   1.000 9.05431  ? 172 TRP A CD1 1 
ATOM   1240 C CD2 . TRP A 1 161 ? 13.55633  -0.40841  9.17628   1.000 7.26027  ? 172 TRP A CD2 1 
ATOM   1241 N NE1 . TRP A 1 161 ? 15.55884  -1.11352  8.45054   1.000 9.75553  ? 172 TRP A NE1 1 
ATOM   1242 C CE2 . TRP A 1 161 ? 14.22966  -1.05310  8.11455   1.000 9.15326  ? 172 TRP A CE2 1 
ATOM   1243 C CE3 . TRP A 1 161 ? 12.16572  -0.24469  9.09319   1.000 7.16582  ? 172 TRP A CE3 1 
ATOM   1244 C CZ2 . TRP A 1 161 ? 13.55493  -1.51932  6.96894   1.000 9.00690  ? 172 TRP A CZ2 1 
ATOM   1245 C CZ3 . TRP A 1 161 ? 11.49899  -0.71264  7.96190   1.000 8.33302  ? 172 TRP A CZ3 1 
ATOM   1246 C CH2 . TRP A 1 161 ? 12.20014  -1.33758  6.90964   1.000 7.72489  ? 172 TRP A CH2 1 
ATOM   1247 N N   . MET A 1 162 ? 12.08963  3.20576   12.33599  1.000 7.23774  ? 173 MET A N   1 
ATOM   1248 C CA  A MET A 1 162 ? 11.24788  3.67235   13.42820  0.761 7.38746  ? 173 MET A CA  1 
ATOM   1249 C CA  B MET A 1 162 ? 11.23587  3.67453   13.41770  0.239 7.45622  ? 173 MET A CA  1 
ATOM   1250 C C   . MET A 1 162 ? 10.40583  2.51691   13.95946  1.000 6.36349  ? 173 MET A C   1 
ATOM   1251 O O   . MET A 1 162 ? 9.80524   1.76120   13.18342  1.000 7.54310  ? 173 MET A O   1 
ATOM   1252 C CB  A MET A 1 162 ? 10.35187  4.81693   12.96423  0.761 8.83248  ? 173 MET A CB  1 
ATOM   1253 C CB  B MET A 1 162 ? 10.30539  4.76453   12.89205  0.239 8.87227  ? 173 MET A CB  1 
ATOM   1254 C CG  A MET A 1 162 ? 11.14014  6.09236   12.69889  0.761 11.39782 ? 173 MET A CG  1 
ATOM   1255 C CG  B MET A 1 162 ? 11.04084  5.94144   12.28102  0.239 9.30415  ? 173 MET A CG  1 
ATOM   1256 S SD  A MET A 1 162 ? 10.06431  7.38640   12.06756  0.761 9.53470  ? 173 MET A SD  1 
ATOM   1257 S SD  B MET A 1 162 ? 11.06362  7.34201   13.41080  0.239 14.30004 ? 173 MET A SD  1 
ATOM   1258 C CE  A MET A 1 162 ? 9.16337   7.88226   13.53735  0.761 14.12852 ? 173 MET A CE  1 
ATOM   1259 C CE  B MET A 1 162 ? 9.31281   7.59957   13.68924  0.239 13.58941 ? 173 MET A CE  1 
ATOM   1260 N N   . GLU A 1 163 ? 10.37263  2.38249   15.28900  1.000 7.29214  ? 174 GLU A N   1 
ATOM   1261 C CA  . GLU A 1 163 ? 9.49188   1.42330   15.93001  1.000 7.59157  ? 174 GLU A CA  1 
ATOM   1262 C C   . GLU A 1 163 ? 8.04665   1.87982   15.71958  1.000 7.16430  ? 174 GLU A C   1 
ATOM   1263 O O   . GLU A 1 163 ? 7.80071   3.04099   15.37581  1.000 8.27307  ? 174 GLU A O   1 
ATOM   1264 C CB  . GLU A 1 163 ? 9.85457   1.30437   17.42025  1.000 8.40324  ? 174 GLU A CB  1 
ATOM   1265 C CG  . GLU A 1 163 ? 11.16112  0.51186   17.64179  1.000 9.83448  ? 174 GLU A CG  1 
ATOM   1266 C CD  . GLU A 1 163 ? 11.62304  0.44113   19.09781  1.000 10.74661 ? 174 GLU A CD  1 
ATOM   1267 O OE1 . GLU A 1 163 ? 11.01457  1.09813   19.97205  1.000 15.97160 ? 174 GLU A OE1 1 
ATOM   1268 O OE2 . GLU A 1 163 ? 12.61895  -0.27663  19.35276  1.000 13.04891 ? 174 GLU A OE2 1 
ATOM   1269 N N   . PRO A 1 164 ? 7.07469   0.98032   15.89159  1.000 5.82273  ? 175 PRO A N   1 
ATOM   1270 C CA  . PRO A 1 164 ? 5.68973   1.28590   15.49281  1.000 6.69629  ? 175 PRO A CA  1 
ATOM   1271 C C   . PRO A 1 164 ? 5.12011   2.52463   16.15978  1.000 7.33131  ? 175 PRO A C   1 
ATOM   1272 O O   . PRO A 1 164 ? 5.30193   2.75697   17.36254  1.000 9.67341  ? 175 PRO A O   1 
ATOM   1273 C CB  . PRO A 1 164 ? 4.91906   0.02566   15.90525  1.000 9.89751  ? 175 PRO A CB  1 
ATOM   1274 C CG  . PRO A 1 164 ? 5.95456   -1.04731  15.84071  1.000 9.60723  ? 175 PRO A CG  1 
ATOM   1275 C CD  . PRO A 1 164 ? 7.20484   -0.41602  16.34860  1.000 10.11261 ? 175 PRO A CD  1 
ATOM   1276 N N   . TYR A 1 165 ? 4.44563   3.33080   15.34657  1.000 8.53043  ? 176 TYR A N   1 
ATOM   1277 C CA  . TYR A 1 165 ? 3.76228   4.52156   15.82965  1.000 7.06230  ? 176 TYR A CA  1 
ATOM   1278 C C   . TYR A 1 165 ? 2.50217   4.74747   15.01317  1.000 6.51770  ? 176 TYR A C   1 
ATOM   1279 O O   . TYR A 1 165 ? 2.38223   4.30090   13.86845  1.000 7.81822  ? 176 TYR A O   1 
ATOM   1280 C CB  . TYR A 1 165 ? 4.67093   5.76080   15.75274  1.000 6.84496  ? 176 TYR A CB  1 
ATOM   1281 C CG  . TYR A 1 165 ? 5.10365   6.17857   14.34922  1.000 8.33656  ? 176 TYR A CG  1 
ATOM   1282 C CD1 . TYR A 1 165 ? 6.08683   5.46955   13.66210  1.000 10.08768 ? 176 TYR A CD1 1 
ATOM   1283 C CD2 . TYR A 1 165 ? 4.54174   7.29676   13.71842  1.000 7.37662  ? 176 TYR A CD2 1 
ATOM   1284 C CE1 . TYR A 1 165 ? 6.49981   5.85631   12.39586  1.000 8.72485  ? 176 TYR A CE1 1 
ATOM   1285 C CE2 . TYR A 1 165 ? 4.95584   7.69159   12.45747  1.000 7.45101  ? 176 TYR A CE2 1 
ATOM   1286 C CZ  . TYR A 1 165 ? 5.93125   6.96915   11.79554  1.000 8.60704  ? 176 TYR A CZ  1 
ATOM   1287 O OH  . TYR A 1 165 ? 6.34940   7.37754   10.53109  1.000 9.00012  ? 176 TYR A OH  1 
ATOM   1288 N N   . LEU A 1 166 ? 1.55498   5.46216   15.62310  1.000 9.08073  ? 177 LEU A N   1 
ATOM   1289 C CA  . LEU A 1 166 ? 0.35967   5.91156   14.91866  1.000 8.58319  ? 177 LEU A CA  1 
ATOM   1290 C C   . LEU A 1 166 ? 0.73356   7.14891   14.11425  1.000 7.62094  ? 177 LEU A C   1 
ATOM   1291 O O   . LEU A 1 166 ? 1.09089   8.18312   14.69011  1.000 10.22424 ? 177 LEU A O   1 
ATOM   1292 C CB  . LEU A 1 166 ? -0.74577  6.24262   15.92037  1.000 11.11338 ? 177 LEU A CB  1 
ATOM   1293 C CG  . LEU A 1 166 ? -2.00542  6.83576   15.28679  1.000 14.48443 ? 177 LEU A CG  1 
ATOM   1294 C CD1 . LEU A 1 166 ? -2.61621  5.87729   14.26715  1.000 14.29512 ? 177 LEU A CD1 1 
ATOM   1295 C CD2 . LEU A 1 166 ? -3.01403  7.21026   16.36317  1.000 15.61132 ? 177 LEU A CD2 1 
ATOM   1296 N N   . ASN A 1 167 ? 0.69796   7.02913   12.79350  1.000 7.31388  ? 178 ASN A N   1 
ATOM   1297 C CA  . ASN A 1 167 ? 0.78457   8.20259   11.92907  1.000 7.00559  ? 178 ASN A CA  1 
ATOM   1298 C C   . ASN A 1 167 ? -0.60833  8.81359   11.81641  1.000 8.07376  ? 178 ASN A C   1 
ATOM   1299 O O   . ASN A 1 167 ? -1.48597  8.27459   11.13233  1.000 9.15089  ? 178 ASN A O   1 
ATOM   1300 C CB  . ASN A 1 167 ? 1.32537   7.81092   10.55972  1.000 6.22822  ? 178 ASN A CB  1 
ATOM   1301 C CG  . ASN A 1 167 ? 1.52093   9.01333   9.64397   1.000 10.23798 ? 178 ASN A CG  1 
ATOM   1302 O OD1 . ASN A 1 167 ? 0.66047   9.89956   9.56737   1.000 11.47324 ? 178 ASN A OD1 1 
ATOM   1303 N ND2 . ASN A 1 167 ? 2.64598   9.04599   8.93312   1.000 10.41275 ? 178 ASN A ND2 1 
ATOM   1304 N N   . SER A 1 168 ? -0.81084  9.94482   12.48352  1.000 8.26831  ? 179 SER A N   1 
ATOM   1305 C CA  . SER A 1 168 ? -2.11629  10.59665  12.49704  1.000 6.19933  ? 179 SER A CA  1 
ATOM   1306 C C   . SER A 1 168 ? -2.41834  11.37265  11.21871  1.000 9.44821  ? 179 SER A C   1 
ATOM   1307 O O   . SER A 1 168 ? -3.56867  11.77737  11.01990  1.000 14.32614 ? 179 SER A O   1 
ATOM   1308 C CB  . SER A 1 168 ? -2.19655  11.52424  13.71319  1.000 8.64232  ? 179 SER A CB  1 
ATOM   1309 O OG  . SER A 1 168 ? -2.39470  10.76503  14.89311  1.000 14.67800 ? 179 SER A OG  1 
ATOM   1310 N N   . ASN A 1 169 ? -1.43376  11.58220  10.34535  1.000 9.36838  ? 180 ASN A N   1 
ATOM   1311 C CA  . ASN A 1 169 ? -1.72814  12.20749  9.06069   1.000 9.77093  ? 180 ASN A CA  1 
ATOM   1312 C C   . ASN A 1 169 ? -2.43931  11.25556  8.12455   1.000 14.14366 ? 180 ASN A C   1 
ATOM   1313 O O   . ASN A 1 169 ? -3.19406  11.69046  7.25486   1.000 14.53948 ? 180 ASN A O   1 
ATOM   1314 C CB  . ASN A 1 169 ? -0.44980  12.73586  8.40383   1.000 10.70084 ? 180 ASN A CB  1 
ATOM   1315 C CG  . ASN A 1 169 ? 0.36627   13.57720  9.34262   1.000 7.61187  ? 180 ASN A CG  1 
ATOM   1316 O OD1 . ASN A 1 169 ? -0.15160  14.53265  9.91790   1.000 12.33727 ? 180 ASN A OD1 1 
ATOM   1317 N ND2 . ASN A 1 169 ? 1.64463   13.23876  9.51890   1.000 7.46690  ? 180 ASN A ND2 1 
ATOM   1318 N N   . ILE A 1 170 ? -2.21013  9.95719   8.25487   1.000 11.52802 ? 181 ILE A N   1 
ATOM   1319 C CA  . ILE A 1 170 ? -2.88789  9.00936   7.38331   1.000 12.51618 ? 181 ILE A CA  1 
ATOM   1320 C C   . ILE A 1 170 ? -3.75837  8.01697   8.13357   1.000 12.54934 ? 181 ILE A C   1 
ATOM   1321 O O   . ILE A 1 170 ? -4.56807  7.33015   7.49152   1.000 13.39818 ? 181 ILE A O   1 
ATOM   1322 C CB  . ILE A 1 170 ? -1.93978  8.30926   6.38511   1.000 18.07248 ? 181 ILE A CB  1 
ATOM   1323 C CG1 . ILE A 1 170 ? -1.03382  7.32553   7.09572   1.000 13.04828 ? 181 ILE A CG1 1 
ATOM   1324 C CG2 . ILE A 1 170 ? -1.12749  9.34201   5.54854   1.000 16.45697 ? 181 ILE A CG2 1 
ATOM   1325 C CD1 . ILE A 1 170 ? -0.46893  6.26735   6.13228   1.000 17.34388 ? 181 ILE A CD1 1 
ATOM   1326 N N   . GLY A 1 171 ? -3.65709  7.95181   9.46176   1.000 10.92847 ? 182 GLY A N   1 
ATOM   1327 C CA  . GLY A 1 171 ? -4.53633  7.10982   10.25579  1.000 13.48498 ? 182 GLY A CA  1 
ATOM   1328 C C   . GLY A 1 171 ? -4.11903  5.66092   10.35711  1.000 16.35641 ? 182 GLY A C   1 
ATOM   1329 O O   . GLY A 1 171 ? -4.97795  4.79068   10.53892  1.000 17.18299 ? 182 GLY A O   1 
ATOM   1330 N N   . VAL A 1 172 ? -2.82066  5.37146   10.26062  1.000 12.39681 ? 183 VAL A N   1 
ATOM   1331 C CA  . VAL A 1 172 ? -2.31352  4.00837   10.17310  1.000 12.35867 ? 183 VAL A CA  1 
ATOM   1332 C C   . VAL A 1 172 ? -1.19024  3.83153   11.18876  1.000 10.47604 ? 183 VAL A C   1 
ATOM   1333 O O   . VAL A 1 172 ? -0.32717  4.70154   11.32974  1.000 11.35959 ? 183 VAL A O   1 
ATOM   1334 C CB  . VAL A 1 172 ? -1.78775  3.68981   8.75124   1.000 13.24109 ? 183 VAL A CB  1 
ATOM   1335 C CG1 . VAL A 1 172 ? -1.35825  2.24290   8.65935   1.000 15.18596 ? 183 VAL A CG1 1 
ATOM   1336 C CG2 . VAL A 1 172 ? -2.84574  3.99031   7.67919   1.000 19.77437 ? 183 VAL A CG2 1 
ATOM   1337 N N   . TYR A 1 173 ? -1.20763  2.70626   11.90533  1.000 9.04857  ? 184 TYR A N   1 
ATOM   1338 C CA  . TYR A 1 173 ? -0.09954  2.31776   12.76599  1.000 6.76560  ? 184 TYR A CA  1 
ATOM   1339 C C   . TYR A 1 173 ? 0.96918   1.67264   11.88198  1.000 6.62074  ? 184 TYR A C   1 
ATOM   1340 O O   . TYR A 1 173 ? 0.68129   0.70386   11.16070  1.000 9.05148  ? 184 TYR A O   1 
ATOM   1341 C CB  . TYR A 1 173 ? -0.64773  1.31463   13.78455  1.000 10.23051 ? 184 TYR A CB  1 
ATOM   1342 C CG  . TYR A 1 173 ? 0.18228   1.10682   15.01325  1.000 12.61046 ? 184 TYR A CG  1 
ATOM   1343 C CD1 . TYR A 1 173 ? 0.37868   2.12169   15.93667  1.000 12.14897 ? 184 TYR A CD1 1 
ATOM   1344 C CD2 . TYR A 1 173 ? 0.74500   -0.13632  15.27093  1.000 13.79364 ? 184 TYR A CD2 1 
ATOM   1345 C CE1 . TYR A 1 173 ? 1.13910   1.91595   17.07540  1.000 12.15524 ? 184 TYR A CE1 1 
ATOM   1346 C CE2 . TYR A 1 173 ? 1.50062   -0.35688  16.39870  1.000 15.73419 ? 184 TYR A CE2 1 
ATOM   1347 C CZ  . TYR A 1 173 ? 1.68433   0.66552   17.30607  1.000 14.19182 ? 184 TYR A CZ  1 
ATOM   1348 O OH  . TYR A 1 173 ? 2.43698   0.43494   18.43144  1.000 16.03480 ? 184 TYR A OH  1 
ATOM   1349 N N   . MET A 1 174 ? 2.19456   2.21456   11.90521  1.000 6.67173  ? 185 MET A N   1 
ATOM   1350 C CA  . MET A 1 174 ? 3.15650   1.87395   10.85858  1.000 6.98190  ? 185 MET A CA  1 
ATOM   1351 C C   . MET A 1 174 ? 4.55901   1.82343   11.45585  1.000 7.70165  ? 185 MET A C   1 
ATOM   1352 O O   . MET A 1 174 ? 4.80948   2.32278   12.56130  1.000 7.00731  ? 185 MET A O   1 
ATOM   1353 C CB  . MET A 1 174 ? 3.26726   2.97693   9.78760   1.000 7.83262  ? 185 MET A CB  1 
ATOM   1354 C CG  . MET A 1 174 ? 3.33180   4.39530   10.36510  1.000 7.21589  ? 185 MET A CG  1 
ATOM   1355 S SD  . MET A 1 174 ? 3.80181   5.61155   9.09830   1.000 8.65430  ? 185 MET A SD  1 
ATOM   1356 C CE  . MET A 1 174 ? 2.36582   5.50059   8.03467   1.000 10.53301 ? 185 MET A CE  1 
ATOM   1357 N N   . ILE A 1 175 ? 5.47602   1.22676   10.69113  1.000 7.24762  ? 186 ILE A N   1 
ATOM   1358 C CA  . ILE A 1 175 ? 6.91495   1.42948   10.85436  1.000 6.35295  ? 186 ILE A CA  1 
ATOM   1359 C C   . ILE A 1 175 ? 7.43211   2.17287   9.62547   1.000 6.17954  ? 186 ILE A C   1 
ATOM   1360 O O   . ILE A 1 175 ? 6.74912   2.27862   8.60018   1.000 7.35313  ? 186 ILE A O   1 
ATOM   1361 C CB  . ILE A 1 175 ? 7.69128   0.11675   11.12159  1.000 6.40707  ? 186 ILE A CB  1 
ATOM   1362 C CG1 . ILE A 1 175 ? 7.54329   -0.88237  9.96983   1.000 7.44346  ? 186 ILE A CG1 1 
ATOM   1363 C CG2 . ILE A 1 175 ? 7.19284   -0.50328  12.41504  1.000 8.69163  ? 186 ILE A CG2 1 
ATOM   1364 C CD1 . ILE A 1 175 ? 8.58454   -2.03240  10.04828  1.000 8.79811  ? 186 ILE A CD1 1 
ATOM   1365 N N   . SER A 1 176 ? 8.64341   2.71850   9.73951   1.000 6.31713  ? 187 SER A N   1 
ATOM   1366 C CA  . SER A 1 176 ? 9.19741   3.56146   8.67984   1.000 5.92263  ? 187 SER A CA  1 
ATOM   1367 C C   . SER A 1 176 ? 10.69678  3.33416   8.59647   1.000 6.87986  ? 187 SER A C   1 
ATOM   1368 O O   . SER A 1 176 ? 11.35574  3.12740   9.62120   1.000 7.62878  ? 187 SER A O   1 
ATOM   1369 C CB  . SER A 1 176 ? 9.02391   5.05125   8.99930   1.000 9.05418  ? 187 SER A CB  1 
ATOM   1370 O OG  . SER A 1 176 ? 7.67709   5.39033   9.28460   1.000 9.47995  ? 187 SER A OG  1 
ATOM   1371 N N   . TYR A 1 177 ? 11.23541  3.39188   7.38234   1.000 6.79982  ? 188 TYR A N   1 
ATOM   1372 C CA  . TYR A 1 177 ? 12.67804  3.42058   7.16225   1.000 5.17642  ? 188 TYR A CA  1 
ATOM   1373 C C   . TYR A 1 177 ? 13.02300  4.76927   6.53943   1.000 5.00879  ? 188 TYR A C   1 
ATOM   1374 O O   . TYR A 1 177 ? 12.52421  5.09726   5.45583   1.000 6.07042  ? 188 TYR A O   1 
ATOM   1375 C CB  . TYR A 1 177 ? 13.11972  2.28158   6.23976   1.000 6.53162  ? 188 TYR A CB  1 
ATOM   1376 C CG  . TYR A 1 177 ? 14.61633  2.23084   6.03514   1.000 5.82520  ? 188 TYR A CG  1 
ATOM   1377 C CD1 . TYR A 1 177 ? 15.48073  1.99313   7.10317   1.000 6.97779  ? 188 TYR A CD1 1 
ATOM   1378 C CD2 . TYR A 1 177 ? 15.17031  2.43833   4.77709   1.000 7.99163  ? 188 TYR A CD2 1 
ATOM   1379 C CE1 . TYR A 1 177 ? 16.87297  1.93936   6.92290   1.000 9.15924  ? 188 TYR A CE1 1 
ATOM   1380 C CE2 . TYR A 1 177 ? 16.57084  2.38348   4.59183   1.000 9.90702  ? 188 TYR A CE2 1 
ATOM   1381 C CZ  . TYR A 1 177 ? 17.40478  2.13212   5.66272   1.000 10.55994 ? 188 TYR A CZ  1 
ATOM   1382 O OH  . TYR A 1 177 ? 18.78322  2.07621   5.49037   1.000 13.57507 ? 188 TYR A OH  1 
ATOM   1383 N N   . VAL A 1 178 ? 13.84969  5.55519   7.23410   1.000 4.97919  ? 189 VAL A N   1 
ATOM   1384 C CA  . VAL A 1 178 ? 14.14517  6.93805   6.86106   1.000 5.07992  ? 189 VAL A CA  1 
ATOM   1385 C C   . VAL A 1 178 ? 15.64904  7.16023   6.86189   1.000 6.04848  ? 189 VAL A C   1 
ATOM   1386 O O   . VAL A 1 178 ? 16.32849  6.85336   7.84765   1.000 6.69336  ? 189 VAL A O   1 
ATOM   1387 C CB  . VAL A 1 178 ? 13.47868  7.94554   7.82066   1.000 5.04263  ? 189 VAL A CB  1 
ATOM   1388 C CG1 . VAL A 1 178 ? 13.72309  9.39543   7.36624   1.000 5.85268  ? 189 VAL A CG1 1 
ATOM   1389 C CG2 . VAL A 1 178 ? 11.98024  7.65441   7.93081   1.000 6.15880  ? 189 VAL A CG2 1 
ATOM   1390 N N   . ILE A 1 179 ? 16.16005  7.74750   5.78736   1.000 6.25773  ? 190 ILE A N   1 
ATOM   1391 C CA  . ILE A 1 179 ? 17.57270  8.10860   5.71297   1.000 6.68760  ? 190 ILE A CA  1 
ATOM   1392 C C   . ILE A 1 179 ? 17.68491  9.62720   5.72345   1.000 6.75249  ? 190 ILE A C   1 
ATOM   1393 O O   . ILE A 1 179 ? 17.19261  10.28695  4.79252   1.000 8.09056  ? 190 ILE A O   1 
ATOM   1394 C CB  . ILE A 1 179 ? 18.26260  7.54166   4.46463   1.000 9.39740  ? 190 ILE A CB  1 
ATOM   1395 C CG1 . ILE A 1 179 ? 18.13140  6.02408   4.36741   1.000 7.39745  ? 190 ILE A CG1 1 
ATOM   1396 C CG2 . ILE A 1 179 ? 19.74976  7.94010   4.51759   1.000 9.19160  ? 190 ILE A CG2 1 
ATOM   1397 C CD1 . ILE A 1 179 ? 18.74827  5.48785   3.06529   1.000 9.35094  ? 190 ILE A CD1 1 
ATOM   1398 N N   . PRO A 1 180 ? 18.33538  10.22070  6.71796   1.000 6.17489  ? 191 PRO A N   1 
ATOM   1399 C CA  . PRO A 1 180 ? 18.61224  11.65775  6.64680   1.000 6.94661  ? 191 PRO A CA  1 
ATOM   1400 C C   . PRO A 1 180 ? 19.56417  11.98883  5.50476   1.000 7.57759  ? 191 PRO A C   1 
ATOM   1401 O O   . PRO A 1 180 ? 20.53923  11.27199  5.24975   1.000 9.99376  ? 191 PRO A O   1 
ATOM   1402 C CB  . PRO A 1 180 ? 19.25240  11.96685  8.00665   1.000 8.20477  ? 191 PRO A CB  1 
ATOM   1403 C CG  . PRO A 1 180 ? 18.86493  10.80450  8.90501   1.000 11.39221 ? 191 PRO A CG  1 
ATOM   1404 C CD  . PRO A 1 180 ? 18.79484  9.61131   7.98179   1.000 7.54357  ? 191 PRO A CD  1 
ATOM   1405 N N   . ILE A 1 181 ? 19.26802  13.08368  4.81058   1.000 6.87980  ? 192 ILE A N   1 
ATOM   1406 C CA  . ILE A 1 181 ? 20.10994  13.60687  3.74289   1.000 7.42052  ? 192 ILE A CA  1 
ATOM   1407 C C   . ILE A 1 181 ? 20.92423  14.73098  4.36688   1.000 11.25229 ? 192 ILE A C   1 
ATOM   1408 O O   . ILE A 1 181 ? 20.37520  15.77009  4.75358   1.000 9.42089  ? 192 ILE A O   1 
ATOM   1409 C CB  . ILE A 1 181 ? 19.27088  14.11222  2.56159   1.000 8.85185  ? 192 ILE A CB  1 
ATOM   1410 C CG1 . ILE A 1 181 ? 18.46888  12.96113  1.93663   1.000 10.35025 ? 192 ILE A CG1 1 
ATOM   1411 C CG2 . ILE A 1 181 ? 20.15912  14.82924  1.52471   1.000 10.02440 ? 192 ILE A CG2 1 
ATOM   1412 C CD1 . ILE A 1 181 ? 17.37990  13.40447  0.94315   1.000 13.51376 ? 192 ILE A CD1 1 
ATOM   1413 N N   . GLU A 1 182 ? 22.22357  14.50197  4.50659   1.000 11.27341 ? 193 GLU A N   1 
ATOM   1414 C CA  . GLU A 1 182 ? 23.14299  15.44121  5.12766   1.000 12.60502 ? 193 GLU A CA  1 
ATOM   1415 C C   . GLU A 1 182 ? 24.23675  15.73073  4.11858   1.000 15.09584 ? 193 GLU A C   1 
ATOM   1416 O O   . GLU A 1 182 ? 24.58566  14.87439  3.30517   1.000 21.36356 ? 193 GLU A O   1 
ATOM   1417 C CB  . GLU A 1 182 ? 23.78914  14.82846  6.37889   1.000 19.59347 ? 193 GLU A CB  1 
ATOM   1418 C CG  . GLU A 1 182 ? 22.87802  13.89695  7.15990   1.000 29.94635 ? 193 GLU A CG  1 
ATOM   1419 C CD  . GLU A 1 182 ? 23.20201  13.84628  8.64376   1.000 48.10075 ? 193 GLU A CD  1 
ATOM   1420 O OE1 . GLU A 1 182 ? 24.40496  13.83686  8.99726   1.000 45.45822 ? 193 GLU A OE1 1 
ATOM   1421 O OE2 . GLU A 1 182 ? 22.25116  13.79277  9.45606   1.000 45.31831 ? 193 GLU A OE2 1 
ATOM   1422 N N   . VAL A 1 183 ? 24.76415  16.94336  4.14321   1.000 13.39960 ? 194 VAL A N   1 
ATOM   1423 C CA  . VAL A 1 183 ? 25.88564  17.29429  3.28541   1.000 13.46848 ? 194 VAL A CA  1 
ATOM   1424 C C   . VAL A 1 183 ? 26.94563  17.91141  4.17237   1.000 16.06572 ? 194 VAL A C   1 
ATOM   1425 O O   . VAL A 1 183 ? 26.68495  18.92048  4.83921   1.000 15.35881 ? 194 VAL A O   1 
ATOM   1426 C CB  . VAL A 1 183 ? 25.48249  18.25692  2.15777   1.000 19.60314 ? 194 VAL A CB  1 
ATOM   1427 C CG1 . VAL A 1 183 ? 26.68156  18.54967  1.27133   1.000 23.11374 ? 194 VAL A CG1 1 
ATOM   1428 C CG2 . VAL A 1 183 ? 24.35073  17.66052  1.33441   1.000 26.15934 ? 194 VAL A CG2 1 
ATOM   1429 N N   . ASP A 1 184 ? 28.12621  17.29605  4.20738   1.000 16.28042 ? 195 ASP A N   1 
ATOM   1430 C CA  . ASP A 1 184 ? 29.23565  17.80560  5.01449   1.000 19.74820 ? 195 ASP A CA  1 
ATOM   1431 C C   . ASP A 1 184 ? 28.79756  18.01901  6.46331   1.000 22.86567 ? 195 ASP A C   1 
ATOM   1432 O O   . ASP A 1 184 ? 29.15977  19.00805  7.10836   1.000 25.48317 ? 195 ASP A O   1 
ATOM   1433 C CB  . ASP A 1 184 ? 29.83970  19.08035  4.40790   1.000 20.87910 ? 195 ASP A CB  1 
ATOM   1434 C CG  . ASP A 1 184 ? 30.33872  18.88277  2.96838   1.000 21.57859 ? 195 ASP A CG  1 
ATOM   1435 O OD1 . ASP A 1 184 ? 30.81309  17.77328  2.63850   1.000 17.89026 ? 195 ASP A OD1 1 
ATOM   1436 O OD2 . ASP A 1 184 ? 30.30327  19.85914  2.18288   1.000 24.93936 ? 195 ASP A OD2 1 
ATOM   1437 N N   . GLY A 1 185 ? 27.97163  17.09588  6.96438   1.000 16.09510 ? 196 GLY A N   1 
ATOM   1438 C CA  . GLY A 1 185 ? 27.51481  17.09471  8.33865   1.000 18.11440 ? 196 GLY A CA  1 
ATOM   1439 C C   . GLY A 1 185 ? 26.28505  17.93355  8.64280   1.000 16.89663 ? 196 GLY A C   1 
ATOM   1440 O O   . GLY A 1 185 ? 25.81954  17.91805  9.79257   1.000 19.86845 ? 196 GLY A O   1 
ATOM   1441 N N   . GLU A 1 186 ? 25.74812  18.66399  7.66628   1.000 13.47511 ? 197 GLU A N   1 
ATOM   1442 C CA  . GLU A 1 186 ? 24.60512  19.54564  7.87087   1.000 13.65140 ? 197 GLU A CA  1 
ATOM   1443 C C   . GLU A 1 186 ? 23.33187  18.88049  7.35922   1.000 13.28280 ? 197 GLU A C   1 
ATOM   1444 O O   . GLU A 1 186 ? 23.30879  18.32156  6.25829   1.000 13.21598 ? 197 GLU A O   1 
ATOM   1445 C CB  . GLU A 1 186 ? 24.81828  20.86486  7.11932   1.000 12.60628 ? 197 GLU A CB  1 
ATOM   1446 C CG  . GLU A 1 186 ? 26.06535  21.63781  7.52297   1.000 15.78270 ? 197 GLU A CG  1 
ATOM   1447 C CD  . GLU A 1 186 ? 26.28316  22.86824  6.65534   1.000 33.00137 ? 197 GLU A CD  1 
ATOM   1448 O OE1 . GLU A 1 186 ? 25.71910  22.92992  5.54116   1.000 32.50954 ? 197 GLU A OE1 1 
ATOM   1449 O OE2 . GLU A 1 186 ? 27.02272  23.77406  7.08261   1.000 31.04484 ? 197 GLU A OE2 1 
ATOM   1450 N N   . SER A 1 187 ? 22.26102  18.98204  8.14463   1.000 10.68654 ? 198 SER A N   1 
ATOM   1451 C CA  . SER A 1 187 ? 20.98669  18.34641  7.82078   1.000 10.28366 ? 198 SER A CA  1 
ATOM   1452 C C   . SER A 1 187 ? 20.24974  19.11682  6.72692   1.000 8.57845  ? 198 SER A C   1 
ATOM   1453 O O   . SER A 1 187 ? 19.91604  20.29206  6.90151   1.000 10.57886 ? 198 SER A O   1 
ATOM   1454 C CB  . SER A 1 187 ? 20.11645  18.32209  9.07524   1.000 15.41831 ? 198 SER A CB  1 
ATOM   1455 O OG  . SER A 1 187 ? 20.75830  17.59000  10.09884  1.000 26.07449 ? 198 SER A OG  1 
ATOM   1456 N N   . ILE A 1 188 ? 19.96725  18.45025  5.60817   1.000 7.59827  ? 199 ILE A N   1 
ATOM   1457 C CA  . ILE A 1 188 ? 19.22435  19.04443  4.50598   1.000 8.30832  ? 199 ILE A CA  1 
ATOM   1458 C C   . ILE A 1 188 ? 17.79642  18.51792  4.43721   1.000 7.44163  ? 199 ILE A C   1 
ATOM   1459 O O   . ILE A 1 188 ? 16.86104  19.27905  4.18668   1.000 5.93129  ? 199 ILE A O   1 
ATOM   1460 C CB  . ILE A 1 188 ? 19.95877  18.81779  3.16761   1.000 9.10553  ? 199 ILE A CB  1 
ATOM   1461 C CG1 . ILE A 1 188 ? 21.40203  19.31434  3.24445   1.000 11.99453 ? 199 ILE A CG1 1 
ATOM   1462 C CG2 . ILE A 1 188 ? 19.21502  19.53080  2.03546   1.000 10.45308 ? 199 ILE A CG2 1 
ATOM   1463 C CD1 . ILE A 1 188 ? 21.52578  20.79641  3.58213   1.000 18.79007 ? 199 ILE A CD1 1 
ATOM   1464 N N   . GLY A 1 189 ? 17.61531  17.21999  4.63947   1.000 8.81655  ? 200 GLY A N   1 
ATOM   1465 C CA  . GLY A 1 189 ? 16.28528  16.65499  4.60498   1.000 7.84247  ? 200 GLY A CA  1 
ATOM   1466 C C   . GLY A 1 189 ? 16.31115  15.18322  4.94844   1.000 6.92233  ? 200 GLY A C   1 
ATOM   1467 O O   . GLY A 1 189 ? 17.23289  14.69737  5.61474   1.000 7.99104  ? 200 GLY A O   1 
ATOM   1468 N N   . ILE A 1 190 ? 15.26055  14.48141  4.50658   1.000 6.34193  ? 201 ILE A N   1 
ATOM   1469 C CA  . ILE A 1 190 ? 15.09293  13.05069  4.75166   1.000 5.57283  ? 201 ILE A CA  1 
ATOM   1470 C C   . ILE A 1 190 ? 14.46667  12.42024  3.51369   1.000 7.52516  ? 201 ILE A C   1 
ATOM   1471 O O   . ILE A 1 190 ? 13.77639  13.07823  2.73500   1.000 6.40481  ? 201 ILE A O   1 
ATOM   1472 C CB  . ILE A 1 190 ? 14.16127  12.76650  5.95799   1.000 7.83681  ? 201 ILE A CB  1 
ATOM   1473 C CG1 . ILE A 1 190 ? 12.80923  13.45373  5.76842   1.000 8.41360  ? 201 ILE A CG1 1 
ATOM   1474 C CG2 . ILE A 1 190 ? 14.79803  13.18911  7.26334   1.000 8.41946  ? 201 ILE A CG2 1 
ATOM   1475 C CD1 . ILE A 1 190 ? 11.65311  12.76655  6.42459   1.000 13.95631 ? 201 ILE A CD1 1 
ATOM   1476 N N   . ILE A 1 191 ? 14.69506  11.12051  3.33992   1.000 6.00253  ? 202 ILE A N   1 
ATOM   1477 C CA  . ILE A 1 191 ? 13.91813  10.33473  2.38419   1.000 6.28342  ? 202 ILE A CA  1 
ATOM   1478 C C   . ILE A 1 191 ? 13.47849  9.05631   3.08344   1.000 5.58220  ? 202 ILE A C   1 
ATOM   1479 O O   . ILE A 1 191 ? 14.26504  8.44760   3.80769   1.000 7.24763  ? 202 ILE A O   1 
ATOM   1480 C CB  . ILE A 1 191 ? 14.72230  10.03627  1.10084   1.000 8.52352  ? 202 ILE A CB  1 
ATOM   1481 C CG1 . ILE A 1 191 ? 13.87690  9.22999   0.12001   1.000 9.11342  ? 202 ILE A CG1 1 
ATOM   1482 C CG2 . ILE A 1 191 ? 16.05985  9.36312   1.41543   1.000 10.43968 ? 202 ILE A CG2 1 
ATOM   1483 C CD1 . ILE A 1 191 ? 14.52334  9.12722   -1.17303  1.000 20.36072 ? 202 ILE A CD1 1 
ATOM   1484 N N   . GLY A 1 192 ? 12.20788  8.68283   2.92394   1.000 5.04888  ? 203 GLY A N   1 
ATOM   1485 C CA  . GLY A 1 192 ? 11.76846  7.47686   3.60613   1.000 5.55581  ? 203 GLY A CA  1 
ATOM   1486 C C   . GLY A 1 192 ? 10.55212  6.85033   2.96031   1.000 5.29561  ? 203 GLY A C   1 
ATOM   1487 O O   . GLY A 1 192 ? 9.93416   7.41316   2.05623   1.000 5.52329  ? 203 GLY A O   1 
ATOM   1488 N N   . MET A 1 193 ? 10.23865  5.63889   3.43532   1.000 5.99686  ? 204 MET A N   1 
ATOM   1489 C CA  . MET A 1 193 ? 8.96099   4.99356   3.14245   1.000 5.48170  ? 204 MET A CA  1 
ATOM   1490 C C   . MET A 1 193 ? 8.44705   4.25616   4.37165   1.000 5.91409  ? 204 MET A C   1 
ATOM   1491 O O   . MET A 1 193 ? 9.21119   3.90157   5.28041   1.000 7.55668  ? 204 MET A O   1 
ATOM   1492 C CB  . MET A 1 193 ? 8.87866   4.00469   1.94576   1.000 10.56825 ? 204 MET A CB  1 
ATOM   1493 C CG  . MET A 1 193 ? 9.39828   4.50662   0.61390   1.000 5.90620  ? 204 MET A CG  1 
ATOM   1494 S SD  . MET A 1 193 ? 9.73129   3.14264   -0.56226  1.000 10.07386 ? 204 MET A SD  1 
ATOM   1495 C CE  . MET A 1 193 ? 10.15912  4.10778   -1.99183  1.000 12.61371 ? 204 MET A CE  1 
ATOM   1496 N N   . ASP A 1 194 ? 7.11882   4.04916   4.39329   1.000 6.90880  ? 205 ASP A N   1 
ATOM   1497 C CA  . ASP A 1 194 ? 6.41465   3.44936   5.52641   1.000 6.17641  ? 205 ASP A CA  1 
ATOM   1498 C C   . ASP A 1 194 ? 5.79458   2.11815   5.13617   1.000 8.01516  ? 205 ASP A C   1 
ATOM   1499 O O   . ASP A 1 194 ? 5.48733   1.87468   3.96702   1.000 8.22087  ? 205 ASP A O   1 
ATOM   1500 C CB  . ASP A 1 194 ? 5.27104   4.34310   6.01269   1.000 8.10465  ? 205 ASP A CB  1 
ATOM   1501 C CG  . ASP A 1 194 ? 5.72649   5.74039   6.38165   1.000 7.88710  ? 205 ASP A CG  1 
ATOM   1502 O OD1 . ASP A 1 194 ? 6.86741   5.89181   6.87346   1.000 8.48267  ? 205 ASP A OD1 1 
ATOM   1503 O OD2 . ASP A 1 194 ? 4.91776   6.68872   6.20918   1.000 9.69388  ? 205 ASP A OD2 1 
ATOM   1504 N N   . ILE A 1 195 ? 5.58110   1.27418   6.14731   1.000 6.30240  ? 206 ILE A N   1 
ATOM   1505 C CA  . ILE A 1 195 ? 4.90351   -0.01493  5.99108   1.000 6.28126  ? 206 ILE A CA  1 
ATOM   1506 C C   . ILE A 1 195 ? 3.83589   -0.11205  7.07263   1.000 5.92122  ? 206 ILE A C   1 
ATOM   1507 O O   . ILE A 1 195 ? 4.11455   0.18187   8.23847   1.000 7.24523  ? 206 ILE A O   1 
ATOM   1508 C CB  . ILE A 1 195 ? 5.88639   -1.19739  6.15081   1.000 7.83158  ? 206 ILE A CB  1 
ATOM   1509 C CG1 . ILE A 1 195 ? 7.12003   -1.03011  5.25871   1.000 11.94634 ? 206 ILE A CG1 1 
ATOM   1510 C CG2 . ILE A 1 195 ? 5.15652   -2.53538  5.90530   1.000 10.67092 ? 206 ILE A CG2 1 
ATOM   1511 C CD1 . ILE A 1 195 ? 8.24080   -2.05496  5.55811   1.000 11.62853 ? 206 ILE A CD1 1 
ATOM   1512 N N   . ASP A 1 196 ? 2.61644   -0.51297  6.69247   1.000 8.02488  ? 207 ASP A N   1 
ATOM   1513 C CA  . ASP A 1 196 ? 1.56125   -0.79787  7.67488   1.000 9.01014  ? 207 ASP A CA  1 
ATOM   1514 C C   . ASP A 1 196 ? 2.01963   -1.91837  8.60797   1.000 7.94514  ? 207 ASP A C   1 
ATOM   1515 O O   . ASP A 1 196 ? 2.38393   -3.00051  8.14726   1.000 8.84679  ? 207 ASP A O   1 
ATOM   1516 C CB  . ASP A 1 196 ? 0.31362   -1.23180  6.89659   1.000 9.63888  ? 207 ASP A CB  1 
ATOM   1517 C CG  . ASP A 1 196 ? -0.94511  -1.35352  7.75371   1.000 14.95486 ? 207 ASP A CG  1 
ATOM   1518 O OD1 . ASP A 1 196 ? -0.87438  -1.73362  8.93750   1.000 16.01381 ? 207 ASP A OD1 1 
ATOM   1519 O OD2 . ASP A 1 196 ? -2.03566  -1.08339  7.19885   1.000 24.68318 ? 207 ASP A OD2 1 
ATOM   1520 N N   . PHE A 1 197 ? 2.01301   -1.65912  9.91999   1.000 7.90132  ? 208 PHE A N   1 
ATOM   1521 C CA  . PHE A 1 197 ? 2.52564   -2.65919  10.86011  1.000 6.68127  ? 208 PHE A CA  1 
ATOM   1522 C C   . PHE A 1 197 ? 1.69701   -3.94251  10.85311  1.000 8.81631  ? 208 PHE A C   1 
ATOM   1523 O O   . PHE A 1 197 ? 2.21772   -5.00631  11.21584  1.000 10.00222 ? 208 PHE A O   1 
ATOM   1524 C CB  . PHE A 1 197 ? 2.60210   -2.07609  12.27716  1.000 10.75425 ? 208 PHE A CB  1 
ATOM   1525 C CG  . PHE A 1 197 ? 3.35942   -2.94184  13.26010  1.000 10.00528 ? 208 PHE A CG  1 
ATOM   1526 C CD1 . PHE A 1 197 ? 4.63396   -3.40344  12.97332  1.000 10.20782 ? 208 PHE A CD1 1 
ATOM   1527 C CD2 . PHE A 1 197 ? 2.79242   -3.26441  14.47689  1.000 10.65666 ? 208 PHE A CD2 1 
ATOM   1528 C CE1 . PHE A 1 197 ? 5.32937   -4.19166  13.88345  1.000 12.12626 ? 208 PHE A CE1 1 
ATOM   1529 C CE2 . PHE A 1 197 ? 3.49327   -4.03746  15.40614  1.000 11.06176 ? 208 PHE A CE2 1 
ATOM   1530 C CZ  . PHE A 1 197 ? 4.75889   -4.50585  15.09457  1.000 10.76930 ? 208 PHE A CZ  1 
ATOM   1531 N N   . SER A 1 198 ? 0.42975   -3.87256  10.43888  1.000 10.64803 ? 209 SER A N   1 
ATOM   1532 C CA  . SER A 1 198 ? -0.39448  -5.07923  10.36432  1.000 13.49604 ? 209 SER A CA  1 
ATOM   1533 C C   . SER A 1 198 ? 0.12409   -6.09673  9.35129   1.000 11.77653 ? 209 SER A C   1 
ATOM   1534 O O   . SER A 1 198 ? -0.20222  -7.28249  9.46119   1.000 13.89050 ? 209 SER A O   1 
ATOM   1535 C CB  . SER A 1 198 ? -1.85726  -4.72277  10.08539  1.000 16.18963 ? 209 SER A CB  1 
ATOM   1536 O OG  . SER A 1 198 ? -2.02530  -4.30689  8.73842   1.000 20.21982 ? 209 SER A OG  1 
ATOM   1537 N N   . GLU A 1 199 ? 0.93797   -5.68914  8.37343   1.000 12.85914 ? 210 GLU A N   1 
ATOM   1538 C CA  . GLU A 1 199 ? 1.57900   -6.69236  7.52828   1.000 12.17492 ? 210 GLU A CA  1 
ATOM   1539 C C   . GLU A 1 199 ? 2.38256   -7.67936  8.37226   1.000 13.99252 ? 210 GLU A C   1 
ATOM   1540 O O   . GLU A 1 199 ? 2.38862   -8.88401  8.09604   1.000 16.39195 ? 210 GLU A O   1 
ATOM   1541 C CB  . GLU A 1 199 ? 2.46800   -6.02718  6.48055   1.000 15.55365 ? 210 GLU A CB  1 
ATOM   1542 C CG  . GLU A 1 199 ? 1.72753   -5.04541  5.57651   1.000 21.71190 ? 210 GLU A CG  1 
ATOM   1543 C CD  . GLU A 1 199 ? 1.16720   -5.67995  4.30854   1.000 30.00255 ? 210 GLU A CD  1 
ATOM   1544 O OE1 . GLU A 1 199 ? 1.05837   -6.92423  4.23942   1.000 25.66496 ? 210 GLU A OE1 1 
ATOM   1545 O OE2 . GLU A 1 199 ? 0.83551   -4.92032  3.37229   1.000 38.12102 ? 210 GLU A OE2 1 
ATOM   1546 N N   . PHE A 1 200 ? 3.03880   -7.18865  9.42308   1.000 10.42154 ? 211 PHE A N   1 
ATOM   1547 C CA  . PHE A 1 200 ? 3.86435   -8.04943  10.25912  1.000 10.81989 ? 211 PHE A CA  1 
ATOM   1548 C C   . PHE A 1 200 ? 3.03893   -8.77000  11.31186  1.000 12.36871 ? 211 PHE A C   1 
ATOM   1549 O O   . PHE A 1 200 ? 3.25448   -9.96532  11.55036  1.000 13.00514 ? 211 PHE A O   1 
ATOM   1550 C CB  . PHE A 1 200 ? 4.99240   -7.23489  10.89488  1.000 11.68980 ? 211 PHE A CB  1 
ATOM   1551 C CG  . PHE A 1 200 ? 5.81508   -6.49181  9.88566   1.000 11.03437 ? 211 PHE A CG  1 
ATOM   1552 C CD1 . PHE A 1 200 ? 6.84401   -7.13189  9.21093   1.000 12.22922 ? 211 PHE A CD1 1 
ATOM   1553 C CD2 . PHE A 1 200 ? 5.52601   -5.17734  9.56397   1.000 11.83614 ? 211 PHE A CD2 1 
ATOM   1554 C CE1 . PHE A 1 200 ? 7.59700   -6.46062  8.25347   1.000 15.64655 ? 211 PHE A CE1 1 
ATOM   1555 C CE2 . PHE A 1 200 ? 6.26257   -4.51258  8.59390   1.000 12.30177 ? 211 PHE A CE2 1 
ATOM   1556 C CZ  . PHE A 1 200 ? 7.30914   -5.14675  7.94720   1.000 13.78623 ? 211 PHE A CZ  1 
ATOM   1557 N N   . THR A 1 201 ? 2.08430   -8.07825  11.93532  1.000 10.95108 ? 212 THR A N   1 
ATOM   1558 C CA  . THR A 1 201 ? 1.27900   -8.73925  12.96338  1.000 12.83429 ? 212 THR A CA  1 
ATOM   1559 C C   . THR A 1 201 ? 0.38168   -9.82586  12.37184  1.000 14.08934 ? 212 THR A C   1 
ATOM   1560 O O   . THR A 1 201 ? 0.15418   -10.86153 13.01672  1.000 14.38020 ? 212 THR A O   1 
ATOM   1561 C CB  . THR A 1 201 ? 0.48928   -7.72511  13.80220  1.000 12.87007 ? 212 THR A CB  1 
ATOM   1562 O OG1 . THR A 1 201 ? -0.58555  -7.16775  13.03426  1.000 14.63487 ? 212 THR A OG1 1 
ATOM   1563 C CG2 . THR A 1 201 ? 1.40531   -6.62048  14.30646  1.000 15.05910 ? 212 THR A CG2 1 
ATOM   1564 N N   . ASP A 1 202 ? -0.12051  -9.62613  11.14930  1.000 14.49904 ? 213 ASP A N   1 
ATOM   1565 C CA  . ASP A 1 202 ? -0.85058  -10.70189 10.47758  1.000 15.59084 ? 213 ASP A CA  1 
ATOM   1566 C C   . ASP A 1 202 ? 0.02756   -11.93354 10.28480  1.000 17.12175 ? 213 ASP A C   1 
ATOM   1567 O O   . ASP A 1 202 ? -0.42930  -13.06714 10.47867  1.000 16.18711 ? 213 ASP A O   1 
ATOM   1568 C CB  . ASP A 1 202 ? -1.37158  -10.21234 9.12717   1.000 16.18000 ? 213 ASP A CB  1 
ATOM   1569 C CG  . ASP A 1 202 ? -2.55767  -9.26832  9.25970   1.000 25.91967 ? 213 ASP A CG  1 
ATOM   1570 O OD1 . ASP A 1 202 ? -3.07273  -9.10301  10.38268  1.000 31.45771 ? 213 ASP A OD1 1 
ATOM   1571 O OD2 . ASP A 1 202 ? -2.96759  -8.67885  8.23314   1.000 27.21851 ? 213 ASP A OD2 1 
ATOM   1572 N N   . THR A 1 203 ? 1.28466   -11.73646 9.86931   1.000 14.50838 ? 214 THR A N   1 
ATOM   1573 C CA  . THR A 1 203 ? 2.19887   -12.86292 9.73241   1.000 11.70444 ? 214 THR A CA  1 
ATOM   1574 C C   . THR A 1 203 ? 2.42397   -13.54559 11.08196  1.000 14.19511 ? 214 THR A C   1 
ATOM   1575 O O   . THR A 1 203 ? 2.37058   -14.77725 11.17150  1.000 15.68999 ? 214 THR A O   1 
ATOM   1576 C CB  . THR A 1 203 ? 3.51395   -12.38680 9.11009   1.000 16.37037 ? 214 THR A CB  1 
ATOM   1577 O OG1 . THR A 1 203 ? 3.25291   -11.86230 7.80245   1.000 20.44222 ? 214 THR A OG1 1 
ATOM   1578 C CG2 . THR A 1 203 ? 4.51444   -13.53102 8.99311   1.000 20.26585 ? 214 THR A CG2 1 
ATOM   1579 N N   . ILE A 1 204 ? 2.63065   -12.76080 12.14655  1.000 13.02699 ? 215 ILE A N   1 
ATOM   1580 C CA  . ILE A 1 204 ? 2.78141   -13.32933 13.48897  1.000 14.23108 ? 215 ILE A CA  1 
ATOM   1581 C C   . ILE A 1 204 ? 1.56716   -14.18319 13.84377  1.000 16.77578 ? 215 ILE A C   1 
ATOM   1582 O O   . ILE A 1 204 ? 1.70025   -15.31442 14.33163  1.000 17.02345 ? 215 ILE A O   1 
ATOM   1583 C CB  . ILE A 1 204 ? 3.00438   -12.21558 14.53589  1.000 12.33245 ? 215 ILE A CB  1 
ATOM   1584 C CG1 . ILE A 1 204 ? 4.32622   -11.46303 14.30456  1.000 14.99923 ? 215 ILE A CG1 1 
ATOM   1585 C CG2 . ILE A 1 204 ? 2.95491   -12.79675 15.95597  1.000 12.85124 ? 215 ILE A CG2 1 
ATOM   1586 C CD1 . ILE A 1 204 ? 5.57698   -12.27690 14.60937  1.000 21.21713 ? 215 ILE A CD1 1 
ATOM   1587 N N   . ASP A 1 205 ? 0.36138   -13.63993 13.62374  1.000 13.56827 ? 216 ASP A N   1 
ATOM   1588 C CA  . ASP A 1 205 ? -0.86630  -14.33996 14.00428  1.000 13.92400 ? 216 ASP A CA  1 
ATOM   1589 C C   . ASP A 1 205 ? -0.99620  -15.68917 13.29773  1.000 15.70955 ? 216 ASP A C   1 
ATOM   1590 O O   . ASP A 1 205 ? -1.59000  -16.62332 13.85056  1.000 23.62567 ? 216 ASP A O   1 
ATOM   1591 C CB  . ASP A 1 205 ? -2.09599  -13.47798 13.69820  1.000 16.58773 ? 216 ASP A CB  1 
ATOM   1592 C CG  . ASP A 1 205 ? -2.22358  -12.26313 14.61279  1.000 23.01389 ? 216 ASP A CG  1 
ATOM   1593 O OD1 . ASP A 1 205 ? -1.59836  -12.23528 15.69827  1.000 21.57225 ? 216 ASP A OD1 1 
ATOM   1594 O OD2 . ASP A 1 205 ? -2.97395  -11.33386 14.24143  1.000 23.35968 ? 216 ASP A OD2 1 
ATOM   1595 N N   . SER A 1 206 ? -0.43553  -15.82234 12.09632  1.000 14.22598 ? 217 SER A N   1 
ATOM   1596 C CA  A SER A 1 206 ? -0.56589  -17.04793 11.31870  0.562 14.56676 ? 217 SER A CA  1 
ATOM   1597 C CA  B SER A 1 206 ? -0.56584  -17.04849 11.31853  0.438 14.61392 ? 217 SER A CA  1 
ATOM   1598 C C   . SER A 1 206 ? 0.46730   -18.10532 11.68406  1.000 17.92417 ? 217 SER A C   1 
ATOM   1599 O O   . SER A 1 206 ? 0.41981   -19.20474 11.12023  1.000 23.83908 ? 217 SER A O   1 
ATOM   1600 C CB  A SER A 1 206 ? -0.45606  -16.72930 9.82682   0.562 20.89347 ? 217 SER A CB  1 
ATOM   1601 C CB  B SER A 1 206 ? -0.46059  -16.73829 9.82261   0.438 20.85917 ? 217 SER A CB  1 
ATOM   1602 O OG  A SER A 1 206 ? 0.90110   -16.62550 9.43551   0.562 18.61647 ? 217 SER A OG  1 
ATOM   1603 O OG  B SER A 1 206 ? -1.35858  -15.71103 9.44448   0.438 19.72202 ? 217 SER A OG  1 
ATOM   1604 N N   . LEU A 1 207 ? 1.38761   -17.80248 12.60020  1.000 16.83387 ? 218 LEU A N   1 
ATOM   1605 C CA  A LEU A 1 207 ? 2.50251   -18.68680 12.92128  0.465 21.15551 ? 218 LEU A CA  1 
ATOM   1606 C CA  B LEU A 1 207 ? 2.49380   -18.69541 12.90701  0.535 21.16554 ? 218 LEU A CA  1 
ATOM   1607 C C   . LEU A 1 207 ? 2.16284   -19.58913 14.09562  1.000 16.79135 ? 218 LEU A C   1 
ATOM   1608 O O   . LEU A 1 207 ? 1.64394   -19.12898 15.11415  1.000 15.60619 ? 218 LEU A O   1 
ATOM   1609 C CB  A LEU A 1 207 ? 3.73834   -17.87153 13.30796  0.465 20.05895 ? 218 LEU A CB  1 
ATOM   1610 C CB  B LEU A 1 207 ? 3.75636   -17.89328 13.22692  0.535 20.14094 ? 218 LEU A CB  1 
ATOM   1611 C CG  A LEU A 1 207 ? 4.15755   -16.79701 12.31871  0.465 19.40263 ? 218 LEU A CG  1 
ATOM   1612 C CG  B LEU A 1 207 ? 4.74543   -18.63936 14.12523  0.535 19.20743 ? 218 LEU A CG  1 
ATOM   1613 C CD1 A LEU A 1 207 ? 5.57853   -16.31028 12.57855  0.465 14.64670 ? 218 LEU A CD1 1 
ATOM   1614 C CD1 B LEU A 1 207 ? 5.56468   -19.63403 13.31979  0.535 25.38600 ? 218 LEU A CD1 1 
ATOM   1615 C CD2 A LEU A 1 207 ? 3.98091   -17.34248 10.90960  0.465 25.89164 ? 218 LEU A CD2 1 
ATOM   1616 C CD2 B LEU A 1 207 ? 5.63697   -17.67791 14.84357  0.535 20.12952 ? 218 LEU A CD2 1 
ATOM   1617 N N   . SER A 1 208 ? 2.49975   -20.86949 13.96227  1.000 17.39322 ? 219 SER A N   1 
ATOM   1618 C CA  . SER A 1 208 ? 2.41891   -21.79849 15.07965  1.000 16.33752 ? 219 SER A CA  1 
ATOM   1619 C C   . SER A 1 208 ? 3.54945   -22.81425 14.95804  1.000 21.40545 ? 219 SER A C   1 
ATOM   1620 O O   . SER A 1 208 ? 4.17579   -22.96031 13.90396  1.000 21.80530 ? 219 SER A O   1 
ATOM   1621 C CB  . SER A 1 208 ? 1.05104   -22.48209 15.13071  1.000 20.28640 ? 219 SER A CB  1 
ATOM   1622 O OG  . SER A 1 208 ? 0.94459   -23.42680 14.08947  1.000 29.77474 ? 219 SER A OG  1 
ATOM   1623 N N   . ILE A 1 209 ? 3.82736   -23.49725 16.06703  1.000 15.64434 ? 220 ILE A N   1 
ATOM   1624 C CA  . ILE A 1 209 ? 4.69506   -24.66887 16.05653  1.000 11.77421 ? 220 ILE A CA  1 
ATOM   1625 C C   . ILE A 1 209 ? 4.20161   -25.59468 17.15879  1.000 11.20637 ? 220 ILE A C   1 
ATOM   1626 O O   . ILE A 1 209 ? 3.64552   -25.14091 18.15966  1.000 12.30947 ? 220 ILE A O   1 
ATOM   1627 C CB  . ILE A 1 209 ? 6.19259   -24.28791 16.21800  1.000 12.57506 ? 220 ILE A CB  1 
ATOM   1628 C CG1 . ILE A 1 209 ? 7.09425   -25.50604 15.94126  1.000 14.15529 ? 220 ILE A CG1 1 
ATOM   1629 C CG2 . ILE A 1 209 ? 6.44231   -23.65854 17.59199  1.000 13.62099 ? 220 ILE A CG2 1 
ATOM   1630 C CD1 . ILE A 1 209 ? 8.57926   -25.17523 15.80511  1.000 14.47687 ? 220 ILE A CD1 1 
ATOM   1631 N N   . PHE A 1 210 ? 4.37738   -26.89727 16.95480  1.000 12.68932 ? 221 PHE A N   1 
ATOM   1632 C CA  . PHE A 1 210 ? 3.96023   -27.91150 17.94925  1.000 14.27102 ? 221 PHE A CA  1 
ATOM   1633 C C   . PHE A 1 210 ? 2.45934   -27.73951 18.20741  1.000 14.47881 ? 221 PHE A C   1 
ATOM   1634 O O   . PHE A 1 210 ? 1.69826   -27.45685 17.27136  1.000 21.36071 ? 221 PHE A O   1 
ATOM   1635 C CB  . PHE A 1 210 ? 4.85379   -27.88453 19.19081  1.000 9.45549  ? 221 PHE A CB  1 
ATOM   1636 C CG  . PHE A 1 210 ? 6.33078   -27.94040 18.88254  1.000 10.44580 ? 221 PHE A CG  1 
ATOM   1637 C CD1 . PHE A 1 210 ? 6.84509   -28.87170 18.00267  1.000 11.47391 ? 221 PHE A CD1 1 
ATOM   1638 C CD2 . PHE A 1 210 ? 7.19783   -27.05041 19.48277  1.000 12.99622 ? 221 PHE A CD2 1 
ATOM   1639 C CE1 . PHE A 1 210 ? 8.19801   -28.91535 17.73333  1.000 11.46134 ? 221 PHE A CE1 1 
ATOM   1640 C CE2 . PHE A 1 210 ? 8.55774   -27.09068 19.21426  1.000 12.06216 ? 221 PHE A CE2 1 
ATOM   1641 C CZ  . PHE A 1 210 ? 9.05621   -28.02304 18.34310  1.000 12.04843 ? 221 PHE A CZ  1 
ATOM   1642 N N   . ASP A 1 211 ? 1.99821   -27.88739 19.44746  1.000 12.03631 ? 222 ASP A N   1 
ATOM   1643 C CA  . ASP A 1 211 ? 0.57330   -27.79222 19.74028  1.000 13.60562 ? 222 ASP A CA  1 
ATOM   1644 C C   . ASP A 1 211 ? 0.12563   -26.38023 20.06348  1.000 15.46862 ? 222 ASP A C   1 
ATOM   1645 O O   . ASP A 1 211 ? -1.01716  -26.01441 19.75805  1.000 20.01598 ? 222 ASP A O   1 
ATOM   1646 C CB  . ASP A 1 211 ? 0.23616   -28.67014 20.94613  1.000 15.23401 ? 222 ASP A CB  1 
ATOM   1647 C CG  . ASP A 1 211 ? 0.77712   -30.06372 20.80455  1.000 32.15495 ? 222 ASP A CG  1 
ATOM   1648 O OD1 . ASP A 1 211 ? 0.37021   -30.74568 19.84547  1.000 30.22889 ? 222 ASP A OD1 1 
ATOM   1649 O OD2 . ASP A 1 211 ? 1.62010   -30.46679 21.63566  1.000 45.02436 ? 222 ASP A OD2 1 
ATOM   1650 N N   . SER A 1 212 ? 0.98366   -25.58124 20.70335  1.000 14.77855 ? 223 SER A N   1 
ATOM   1651 C CA  . SER A 1 212 ? 0.55327   -24.26073 21.14493  1.000 14.57861 ? 223 SER A CA  1 
ATOM   1652 C C   . SER A 1 212 ? 1.67175   -23.22724 21.05592  1.000 15.13505 ? 223 SER A C   1 
ATOM   1653 O O   . SER A 1 212 ? 1.56366   -22.15586 21.66426  1.000 17.14796 ? 223 SER A O   1 
ATOM   1654 C CB  . SER A 1 212 ? -0.02783  -24.32000 22.55797  1.000 15.86345 ? 223 SER A CB  1 
ATOM   1655 O OG  . SER A 1 212 ? 0.97334   -24.62351 23.51712  1.000 17.69067 ? 223 SER A OG  1 
ATOM   1656 N N   . GLY A 1 213 ? 2.73226   -23.51335 20.31191  1.000 10.73139 ? 224 GLY A N   1 
ATOM   1657 C CA  . GLY A 1 213 ? 3.79881   -22.53870 20.15069  1.000 9.77126  ? 224 GLY A CA  1 
ATOM   1658 C C   . GLY A 1 213 ? 3.34499   -21.33601 19.34574  1.000 11.44857 ? 224 GLY A C   1 
ATOM   1659 O O   . GLY A 1 213 ? 2.45959   -21.42614 18.49344  1.000 11.31153 ? 224 GLY A O   1 
ATOM   1660 N N   . TYR A 1 214 ? 3.96743   -20.18415 19.62397  1.000 8.42698  ? 225 TYR A N   1 
ATOM   1661 C CA  . TYR A 1 214 ? 3.61463   -18.95507 18.93474  1.000 8.76574  ? 225 TYR A CA  1 
ATOM   1662 C C   . TYR A 1 214 ? 4.83476   -18.03894 18.89216  1.000 7.77429  ? 225 TYR A C   1 
ATOM   1663 O O   . TYR A 1 214 ? 5.86595   -18.30091 19.52505  1.000 8.23630  ? 225 TYR A O   1 
ATOM   1664 C CB  . TYR A 1 214 ? 2.38962   -18.28458 19.59350  1.000 8.16068  ? 225 TYR A CB  1 
ATOM   1665 C CG  . TYR A 1 214 ? 2.57843   -17.94813 21.06455  1.000 8.84621  ? 225 TYR A CG  1 
ATOM   1666 C CD1 . TYR A 1 214 ? 3.17944   -16.74574 21.45159  1.000 9.74951  ? 225 TYR A CD1 1 
ATOM   1667 C CD2 . TYR A 1 214 ? 2.15022   -18.81886 22.06632  1.000 10.91340 ? 225 TYR A CD2 1 
ATOM   1668 C CE1 . TYR A 1 214 ? 3.36023   -16.43061 22.79667  1.000 10.15655 ? 225 TYR A CE1 1 
ATOM   1669 C CE2 . TYR A 1 214 ? 2.31944   -18.50343 23.40265  1.000 10.92610 ? 225 TYR A CE2 1 
ATOM   1670 C CZ  . TYR A 1 214 ? 2.91971   -17.31661 23.76012  1.000 11.44643 ? 225 TYR A CZ  1 
ATOM   1671 O OH  . TYR A 1 214 ? 3.09368   -17.01662 25.10036  1.000 13.07597 ? 225 TYR A OH  1 
ATOM   1672 N N   . GLY A 1 215 ? 4.72112   -16.96828 18.09998  1.000 7.43138  ? 226 GLY A N   1 
ATOM   1673 C CA  . GLY A 1 215 ? 5.76774   -15.98267 17.98241  1.000 8.48564  ? 226 GLY A CA  1 
ATOM   1674 C C   . GLY A 1 215 ? 5.32789   -14.61502 18.48569  1.000 6.62003  ? 226 GLY A C   1 
ATOM   1675 O O   . GLY A 1 215 ? 4.13945   -14.34835 18.70040  1.000 8.35916  ? 226 GLY A O   1 
ATOM   1676 N N   . PHE A 1 216 ? 6.31640   -13.74219 18.66772  1.000 6.74906  ? 227 PHE A N   1 
ATOM   1677 C CA  . PHE A 1 216 ? 6.03461   -12.36177 19.05404  1.000 7.29582  ? 227 PHE A CA  1 
ATOM   1678 C C   . PHE A 1 216 ? 7.23039   -11.48275 18.69694  1.000 8.03188  ? 227 PHE A C   1 
ATOM   1679 O O   . PHE A 1 216 ? 8.29952   -11.97865 18.33692  1.000 6.43417  ? 227 PHE A O   1 
ATOM   1680 C CB  . PHE A 1 216 ? 5.58489   -12.23298 20.52238  1.000 7.62548  ? 227 PHE A CB  1 
ATOM   1681 C CG  . PHE A 1 216 ? 6.64029   -12.57289 21.54995  1.000 6.65806  ? 227 PHE A CG  1 
ATOM   1682 C CD1 . PHE A 1 216 ? 6.72850   -13.86073 22.06184  1.000 8.12303  ? 227 PHE A CD1 1 
ATOM   1683 C CD2 . PHE A 1 216 ? 7.48447   -11.59566 22.06545  1.000 9.70047  ? 227 PHE A CD2 1 
ATOM   1684 C CE1 . PHE A 1 216 ? 7.67276   -14.17911 23.04410  1.000 7.69017  ? 227 PHE A CE1 1 
ATOM   1685 C CE2 . PHE A 1 216 ? 8.42064   -11.90440 23.05296  1.000 9.77942  ? 227 PHE A CE2 1 
ATOM   1686 C CZ  . PHE A 1 216 ? 8.50906   -13.18793 23.54146  1.000 8.87551  ? 227 PHE A CZ  1 
ATOM   1687 N N   . LEU A 1 217 ? 7.03139   -10.15671 18.77674  1.000 6.61138  ? 228 LEU A N   1 
ATOM   1688 C CA  . LEU A 1 217 ? 8.04311   -9.17631  18.40245  1.000 7.89076  ? 228 LEU A CA  1 
ATOM   1689 C C   . LEU A 1 217 ? 8.37665   -8.29430  19.60074  1.000 8.71761  ? 228 LEU A C   1 
ATOM   1690 O O   . LEU A 1 217 ? 7.47043   -7.77841  20.26491  1.000 8.69115  ? 228 LEU A O   1 
ATOM   1691 C CB  . LEU A 1 217 ? 7.54873   -8.31382  17.23407  1.000 6.84663  ? 228 LEU A CB  1 
ATOM   1692 C CG  . LEU A 1 217 ? 7.40903   -9.04774  15.89743  1.000 9.05960  ? 228 LEU A CG  1 
ATOM   1693 C CD1 . LEU A 1 217 ? 6.59993   -8.20144  14.93564  1.000 11.35812 ? 228 LEU A CD1 1 
ATOM   1694 C CD2 . LEU A 1 217 ? 8.78005   -9.32928  15.29115  1.000 10.51045 ? 228 LEU A CD2 1 
ATOM   1695 N N   . VAL A 1 218 ? 9.67425   -8.08058  19.82808  1.000 8.27713  ? 229 VAL A N   1 
ATOM   1696 C CA  A VAL A 1 218 ? 10.17826  -7.30683  20.95535  0.483 7.84722  ? 229 VAL A CA  1 
ATOM   1697 C CA  B VAL A 1 218 ? 10.17140  -7.28461  20.94776  0.517 7.85307  ? 229 VAL A CA  1 
ATOM   1698 C C   . VAL A 1 218 ? 11.42869  -6.56344  20.49181  1.000 10.78384 ? 229 VAL A C   1 
ATOM   1699 O O   . VAL A 1 218 ? 12.10653  -6.98976  19.55656  1.000 11.38922 ? 229 VAL A O   1 
ATOM   1700 C CB  A VAL A 1 218 ? 10.46671  -8.28972  22.11577  0.483 9.52314  ? 229 VAL A CB  1 
ATOM   1701 C CB  B VAL A 1 218 ? 10.46275  -8.14000  22.20685  0.517 9.41650  ? 229 VAL A CB  1 
ATOM   1702 C CG1 A VAL A 1 218 ? 11.72579  -9.08842  21.82625  0.483 8.23567  ? 229 VAL A CG1 1 
ATOM   1703 C CG1 B VAL A 1 218 ? 9.19533   -8.38699  22.99307  0.517 10.50926 ? 229 VAL A CG1 1 
ATOM   1704 C CG2 A VAL A 1 218 ? 10.54542  -7.58251  23.43730  0.483 9.00762  ? 229 VAL A CG2 1 
ATOM   1705 C CG2 B VAL A 1 218 ? 11.13115  -9.45286  21.81942  0.517 8.21461  ? 229 VAL A CG2 1 
ATOM   1706 N N   . ASN A 1 219 ? 11.72787  -5.43029  21.13050  1.000 9.38449  ? 230 ASN A N   1 
ATOM   1707 C CA  . ASN A 1 219 ? 13.00197  -4.79049  20.83139  1.000 9.07571  ? 230 ASN A CA  1 
ATOM   1708 C C   . ASN A 1 219 ? 14.09331  -5.36216  21.73732  1.000 9.75636  ? 230 ASN A C   1 
ATOM   1709 O O   . ASN A 1 219 ? 13.84115  -6.19597  22.61153  1.000 10.70135 ? 230 ASN A O   1 
ATOM   1710 C CB  . ASN A 1 219 ? 12.91337  -3.25274  20.78934  1.000 10.21886 ? 230 ASN A CB  1 
ATOM   1711 C CG  . ASN A 1 219 ? 12.84461  -2.60027  22.17421  1.000 9.63173  ? 230 ASN A CG  1 
ATOM   1712 O OD1 . ASN A 1 219 ? 12.98951  -3.24989  23.20949  1.000 10.82589 ? 230 ASN A OD1 1 
ATOM   1713 N ND2 . ASN A 1 219 ? 12.62790  -1.28891  22.18305  1.000 10.40639 ? 230 ASN A ND2 1 
ATOM   1714 N N   . GLU A 1 220 ? 15.32722  -4.91420  21.51248  1.000 11.11226 ? 231 GLU A N   1 
ATOM   1715 C CA  . GLU A 1 220 ? 16.48394  -5.46170  22.20971  1.000 12.34378 ? 231 GLU A CA  1 
ATOM   1716 C C   . GLU A 1 220 ? 16.42743  -5.22813  23.71655  1.000 17.20678 ? 231 GLU A C   1 
ATOM   1717 O O   . GLU A 1 220 ? 17.06709  -5.96824  24.46844  1.000 19.53590 ? 231 GLU A O   1 
ATOM   1718 C CB  . GLU A 1 220 ? 17.75632  -4.86166  21.60741  1.000 20.29912 ? 231 GLU A CB  1 
ATOM   1719 C CG  . GLU A 1 220 ? 19.04555  -5.55275  21.99572  1.000 32.09798 ? 231 GLU A CG  1 
ATOM   1720 C CD  . GLU A 1 220 ? 20.23192  -4.60727  21.98395  1.000 46.95867 ? 231 GLU A CD  1 
ATOM   1721 O OE1 . GLU A 1 220 ? 20.04032  -3.41778  21.64714  1.000 54.93979 ? 231 GLU A OE1 1 
ATOM   1722 O OE2 . GLU A 1 220 ? 21.35510  -5.05259  22.30069  1.000 44.44865 ? 231 GLU A OE2 1 
ATOM   1723 N N   . SER A 1 221 ? 15.67297  -4.23120  24.17687  1.000 12.53468 ? 232 SER A N   1 
ATOM   1724 C CA  A SER A 1 221 ? 15.54364  -3.93329  25.59844  0.646 14.12015 ? 232 SER A CA  1 
ATOM   1725 C CA  B SER A 1 221 ? 15.55317  -3.94417  25.59974  0.354 14.11000 ? 232 SER A CA  1 
ATOM   1726 C C   . SER A 1 221 ? 14.34511  -4.61359  26.24057  1.000 14.06289 ? 232 SER A C   1 
ATOM   1727 O O   . SER A 1 221 ? 14.10011  -4.40433  27.43482  1.000 15.98470 ? 232 SER A O   1 
ATOM   1728 C CB  A SER A 1 221 ? 15.43836  -2.41799  25.82202  0.646 14.86952 ? 232 SER A CB  1 
ATOM   1729 C CB  B SER A 1 221 ? 15.49904  -2.42917  25.83412  0.354 14.89103 ? 232 SER A CB  1 
ATOM   1730 O OG  A SER A 1 221 ? 16.40859  -1.72085  25.06835  0.646 19.96546 ? 232 SER A OG  1 
ATOM   1731 O OG  B SER A 1 221 ? 14.25756  -1.89502  25.41427  0.354 13.68209 ? 232 SER A OG  1 
ATOM   1732 N N   . GLY A 1 222 ? 13.58986  -5.40626  25.48539  1.000 11.11614 ? 233 GLY A N   1 
ATOM   1733 C CA  . GLY A 1 222 ? 12.44110  -6.09806  26.03733  1.000 11.67307 ? 233 GLY A CA  1 
ATOM   1734 C C   . GLY A 1 222 ? 11.10958  -5.39676  25.88677  1.000 9.45494  ? 233 GLY A C   1 
ATOM   1735 O O   . GLY A 1 222 ? 10.09675  -5.89765  26.40494  1.000 10.82696 ? 233 GLY A O   1 
ATOM   1736 N N   . LYS A 1 223 ? 11.05300  -4.28427  25.15282  1.000 10.01248 ? 234 LYS A N   1 
ATOM   1737 C CA  . LYS A 1 223 ? 9.78933   -3.59300  24.94095  1.000 12.09574 ? 234 LYS A CA  1 
ATOM   1738 C C   . LYS A 1 223 ? 8.95501   -4.33197  23.89520  1.000 9.45053  ? 234 LYS A C   1 
ATOM   1739 O O   . LYS A 1 223 ? 9.45821   -4.68548  22.82297  1.000 9.88016  ? 234 LYS A O   1 
ATOM   1740 C CB  . LYS A 1 223 ? 10.05806  -2.16101  24.48584  1.000 11.80754 ? 234 LYS A CB  1 
ATOM   1741 C CG  . LYS A 1 223 ? 8.81838   -1.29978  24.34618  1.000 11.45511 ? 234 LYS A CG  1 
ATOM   1742 C CD  . LYS A 1 223 ? 9.20839   0.07730   23.81582  1.000 14.63982 ? 234 LYS A CD  1 
ATOM   1743 C CE  . LYS A 1 223 ? 8.00167   0.99203   23.71730  1.000 20.70004 ? 234 LYS A CE  1 
ATOM   1744 N NZ  . LYS A 1 223 ? 8.40329   2.39013   23.35791  1.000 23.30759 ? 234 LYS A NZ  1 
ATOM   1745 N N   . VAL A 1 224 ? 7.68416   -4.57040  24.21121  1.000 9.97920  ? 235 VAL A N   1 
ATOM   1746 C CA  . VAL A 1 224 ? 6.81154   -5.34022  23.32548  1.000 7.13546  ? 235 VAL A CA  1 
ATOM   1747 C C   . VAL A 1 224 ? 6.44197   -4.48569  22.11708  1.000 8.64115  ? 235 VAL A C   1 
ATOM   1748 O O   . VAL A 1 224 ? 5.86054   -3.40046  22.25954  1.000 10.45607 ? 235 VAL A O   1 
ATOM   1749 C CB  . VAL A 1 224 ? 5.55773   -5.80272  24.07959  1.000 9.04371  ? 235 VAL A CB  1 
ATOM   1750 C CG1 . VAL A 1 224 ? 4.55377   -6.42610  23.11764  1.000 11.90745 ? 235 VAL A CG1 1 
ATOM   1751 C CG2 . VAL A 1 224 ? 5.93242   -6.78403  25.19103  1.000 10.26203 ? 235 VAL A CG2 1 
ATOM   1752 N N   . MET A 1 225 ? 6.81489   -4.96170  20.92333  1.000 8.83900  ? 236 MET A N   1 
ATOM   1753 C CA  . MET A 1 225 ? 6.25830   -4.49345  19.64080  1.000 9.03034  ? 236 MET A CA  1 
ATOM   1754 C C   . MET A 1 225 ? 4.94101   -5.13795  19.24966  1.000 10.54848 ? 236 MET A C   1 
ATOM   1755 O O   . MET A 1 225 ? 4.03546   -4.45023  18.77833  1.000 10.57999 ? 236 MET A O   1 
ATOM   1756 C CB  . MET A 1 225 ? 7.28447   -4.50680  18.50194  1.000 13.40603 ? 236 MET A CB  1 
ATOM   1757 C CG  . MET A 1 225 ? 8.73973   -4.23965  18.81443  1.000 6.44618  ? 236 MET A CG  1 
ATOM   1758 S SD  . MET A 1 225 ? 8.93078   -2.40772  18.99604  1.000 11.77352 ? 236 MET A SD  1 
ATOM   1759 C CE  . MET A 1 225 ? 8.98421   -2.11348  20.76651  1.000 13.01313 ? 236 MET A CE  1 
ATOM   1760 N N   . TYR A 1 226 ? 4.82144   -6.45604  19.38327  1.000 7.66707  ? 237 TYR A N   1 
ATOM   1761 C CA  . TYR A 1 226 ? 3.53515   -7.10992  19.17458  1.000 9.76237  ? 237 TYR A CA  1 
ATOM   1762 C C   . TYR A 1 226 ? 3.55558   -8.43981  19.90869  1.000 9.25521  ? 237 TYR A C   1 
ATOM   1763 O O   . TYR A 1 226 ? 4.47555   -9.23495  19.69436  1.000 8.82998  ? 237 TYR A O   1 
ATOM   1764 C CB  . TYR A 1 226 ? 3.26399   -7.38906  17.68301  1.000 8.34557  ? 237 TYR A CB  1 
ATOM   1765 C CG  . TYR A 1 226 ? 1.93649   -8.07327  17.48975  1.000 9.71680  ? 237 TYR A CG  1 
ATOM   1766 C CD1 . TYR A 1 226 ? 0.74889   -7.43489  17.81194  1.000 12.87278 ? 237 TYR A CD1 1 
ATOM   1767 C CD2 . TYR A 1 226 ? 1.88090   -9.39742  17.07371  1.000 13.48368 ? 237 TYR A CD2 1 
ATOM   1768 C CE1 . TYR A 1 226 ? -0.46118  -8.07256  17.66722  1.000 17.16818 ? 237 TYR A CE1 1 
ATOM   1769 C CE2 . TYR A 1 226 ? 0.66970   -10.05010 16.93364  1.000 15.55761 ? 237 TYR A CE2 1 
ATOM   1770 C CZ  . TYR A 1 226 ? -0.49661  -9.37984  17.23019  1.000 21.80407 ? 237 TYR A CZ  1 
ATOM   1771 O OH  . TYR A 1 226 ? -1.71020  -10.00956 17.09382  1.000 26.59686 ? 237 TYR A OH  1 
ATOM   1772 N N   . HIS A 1 227 ? 2.53934   -8.68622  20.74000  1.000 8.36287  ? 238 HIS A N   1 
ATOM   1773 C CA  . HIS A 1 227 ? 2.35906   -9.95439  21.44237  1.000 9.42121  ? 238 HIS A CA  1 
ATOM   1774 C C   . HIS A 1 227 ? 0.85853   -10.12574 21.63321  1.000 11.54330 ? 238 HIS A C   1 
ATOM   1775 O O   . HIS A 1 227 ? 0.17310   -9.17832  22.02265  1.000 13.05052 ? 238 HIS A O   1 
ATOM   1776 C CB  . HIS A 1 227 ? 3.07782   -9.90191  22.80767  1.000 8.79584  ? 238 HIS A CB  1 
ATOM   1777 C CG  . HIS A 1 227 ? 3.16381   -11.21356 23.53699  1.000 9.65864  ? 238 HIS A CG  1 
ATOM   1778 N ND1 . HIS A 1 227 ? 2.05537   -11.87640 24.01811  1.000 9.24119  ? 238 HIS A ND1 1 
ATOM   1779 C CD2 . HIS A 1 227 ? 4.23904   -11.93984 23.93395  1.000 6.93854  ? 238 HIS A CD2 1 
ATOM   1780 C CE1 . HIS A 1 227 ? 2.43850   -12.98187 24.63657  1.000 8.27318  ? 238 HIS A CE1 1 
ATOM   1781 N NE2 . HIS A 1 227 ? 3.76285   -13.03915 24.60876  1.000 8.15165  ? 238 HIS A NE2 1 
ATOM   1782 N N   . LYS A 1 228 ? 0.34968   -11.33024 21.36311  1.000 9.82150  ? 239 LYS A N   1 
ATOM   1783 C CA  . LYS A 1 228 ? -1.09884  -11.55658 21.41729  1.000 12.95752 ? 239 LYS A CA  1 
ATOM   1784 C C   . LYS A 1 228 ? -1.70008  -11.31078 22.80124  1.000 14.44671 ? 239 LYS A C   1 
ATOM   1785 O O   . LYS A 1 228 ? -2.90387  -11.04510 22.90136  1.000 17.58197 ? 239 LYS A O   1 
ATOM   1786 C CB  . LYS A 1 228 ? -1.45314  -12.97141 20.94960  1.000 13.20347 ? 239 LYS A CB  1 
ATOM   1787 C CG  . LYS A 1 228 ? -0.87614  -14.07448 21.82856  1.000 13.16920 ? 239 LYS A CG  1 
ATOM   1788 C CD  . LYS A 1 228 ? -1.18337  -15.43984 21.24236  1.000 17.19488 ? 239 LYS A CD  1 
ATOM   1789 C CE  . LYS A 1 228 ? -0.88458  -16.54312 22.23311  1.000 23.64310 ? 239 LYS A CE  1 
ATOM   1790 N NZ  . LYS A 1 228 ? -1.87366  -16.51385 23.35094  1.000 27.44049 ? 239 LYS A NZ  1 
ATOM   1791 N N   . ASP A 1 229 ? -0.90447  -11.38962 23.86947  1.000 12.40898 ? 240 ASP A N   1 
ATOM   1792 C CA  . ASP A 1 229 ? -1.42293  -11.26698 25.22738  1.000 13.45455 ? 240 ASP A CA  1 
ATOM   1793 C C   . ASP A 1 229 ? -0.90346  -10.06694 25.99502  1.000 18.75434 ? 240 ASP A C   1 
ATOM   1794 O O   . ASP A 1 229 ? -1.53691  -9.67266  26.97856  1.000 25.64315 ? 240 ASP A O   1 
ATOM   1795 C CB  . ASP A 1 229 ? -1.09219  -12.52159 26.04468  1.000 16.47097 ? 240 ASP A CB  1 
ATOM   1796 C CG  . ASP A 1 229 ? -1.70087  -13.77318 25.45829  1.000 18.35688 ? 240 ASP A CG  1 
ATOM   1797 O OD1 . ASP A 1 229 ? -2.92281  -13.77652 25.21801  1.000 20.25616 ? 240 ASP A OD1 1 
ATOM   1798 O OD2 . ASP A 1 229 ? -0.96153  -14.75363 25.23287  1.000 21.58627 ? 240 ASP A OD2 1 
ATOM   1799 N N   . LEU A 1 230 ? 0.21505   -9.48111  25.59361  1.000 14.39948 ? 241 LEU A N   1 
ATOM   1800 C CA  . LEU A 1 230 ? 0.84694   -8.40672  26.34176  1.000 14.23940 ? 241 LEU A CA  1 
ATOM   1801 C C   . LEU A 1 230 ? 0.63373   -7.08433  25.62562  1.000 14.11687 ? 241 LEU A C   1 
ATOM   1802 O O   . LEU A 1 230 ? 0.60992   -7.02631  24.39168  1.000 20.41401 ? 241 LEU A O   1 
ATOM   1803 C CB  . LEU A 1 230 ? 2.34235   -8.67866  26.53183  1.000 13.76686 ? 241 LEU A CB  1 
ATOM   1804 C CG  . LEU A 1 230 ? 2.62743   -9.98118  27.25970  1.000 14.12803 ? 241 LEU A CG  1 
ATOM   1805 C CD1 . LEU A 1 230 ? 4.11439   -10.23889 27.35281  1.000 15.65845 ? 241 LEU A CD1 1 
ATOM   1806 C CD2 . LEU A 1 230 ? 1.99875   -9.93279  28.65340  1.000 16.60928 ? 241 LEU A CD2 1 
ATOM   1807 N N   . GLU A 1 231 ? 0.46211   -6.02472  26.40975  1.000 16.70444 ? 242 GLU A N   1 
ATOM   1808 C CA  . GLU A 1 231 ? 0.13407   -4.72683  25.84130  1.000 16.82785 ? 242 GLU A CA  1 
ATOM   1809 C C   . GLU A 1 231 ? 1.31111   -4.16051  25.05896  1.000 15.50744 ? 242 GLU A C   1 
ATOM   1810 O O   . GLU A 1 231 ? 2.46601   -4.24338  25.49551  1.000 17.34276 ? 242 GLU A O   1 
ATOM   1811 C CB  . GLU A 1 231 ? -0.24352  -3.76578  26.96883  1.000 27.42285 ? 242 GLU A CB  1 
ATOM   1812 C CG  . GLU A 1 231 ? -0.21805  -2.30564  26.56746  1.000 34.53938 ? 242 GLU A CG  1 
ATOM   1813 C CD  . GLU A 1 231 ? -1.07946  -1.43348  27.46246  1.000 48.02334 ? 242 GLU A CD  1 
ATOM   1814 O OE1 . GLU A 1 231 ? -1.96672  -0.73436  26.92785  1.000 51.25381 ? 242 GLU A OE1 1 
ATOM   1815 O OE2 . GLU A 1 231 ? -0.86140  -1.43747  28.69402  1.000 53.42271 ? 242 GLU A OE2 1 
ATOM   1816 N N   . ILE A 1 232 ? 1.01183   -3.57319  23.89276  1.000 18.04370 ? 243 ILE A N   1 
ATOM   1817 C CA  . ILE A 1 232 ? 2.04605   -2.91163  23.10658  1.000 16.69586 ? 243 ILE A CA  1 
ATOM   1818 C C   . ILE A 1 232 ? 2.75067   -1.86544  23.95836  1.000 17.98204 ? 243 ILE A C   1 
ATOM   1819 O O   . ILE A 1 232 ? 2.11296   -1.10477  24.70012  1.000 18.62595 ? 243 ILE A O   1 
ATOM   1820 C CB  . ILE A 1 232 ? 1.44542   -2.27027  21.84343  1.000 23.17136 ? 243 ILE A CB  1 
ATOM   1821 C CG1 . ILE A 1 232 ? 1.39338   -3.26720  20.69018  1.000 25.76885 ? 243 ILE A CG1 1 
ATOM   1822 C CG2 . ILE A 1 232 ? 2.24690   -1.05614  21.42111  1.000 35.49355 ? 243 ILE A CG2 1 
ATOM   1823 C CD1 . ILE A 1 232 ? 0.73031   -2.70451  19.45349  1.000 30.25193 ? 243 ILE A CD1 1 
ATOM   1824 N N   . GLY A 1 233 ? 4.08005   -1.83025  23.86672  1.000 11.61318 ? 244 GLY A N   1 
ATOM   1825 C CA  . GLY A 1 233 ? 4.86540   -0.83886  24.56382  1.000 13.31573 ? 244 GLY A CA  1 
ATOM   1826 C C   . GLY A 1 233 ? 5.21686   -1.17715  25.99231  1.000 11.11249 ? 244 GLY A C   1 
ATOM   1827 O O   . GLY A 1 233 ? 6.02834   -0.46237  26.59741  1.000 19.40443 ? 244 GLY A O   1 
ATOM   1828 N N   . SER A 1 234 ? 4.65202   -2.24279  26.55081  1.000 14.36845 ? 245 SER A N   1 
ATOM   1829 C CA  . SER A 1 234 ? 5.05590   -2.69887  27.86822  1.000 14.79919 ? 245 SER A CA  1 
ATOM   1830 C C   . SER A 1 234 ? 6.39370   -3.43451  27.76628  1.000 15.34681 ? 245 SER A C   1 
ATOM   1831 O O   . SER A 1 234 ? 6.85962   -3.77501  26.67360  1.000 14.61559 ? 245 SER A O   1 
ATOM   1832 C CB  . SER A 1 234 ? 3.97511   -3.60467  28.44575  1.000 13.89325 ? 245 SER A CB  1 
ATOM   1833 O OG  . SER A 1 234 ? 3.88178   -4.82213  27.70712  1.000 16.75969 ? 245 SER A OG  1 
ATOM   1834 N N   . ASN A 1 235 ? 7.03687   -3.66426  28.90812  1.000 12.90772 ? 246 ASN A N   1 
ATOM   1835 C CA  . ASN A 1 235 ? 8.28014   -4.42555  28.93372  1.000 12.93506 ? 246 ASN A CA  1 
ATOM   1836 C C   . ASN A 1 235 ? 7.99273   -5.85091  29.37514  1.000 11.72455 ? 246 ASN A C   1 
ATOM   1837 O O   . ASN A 1 235 ? 7.13449   -6.08256  30.23278  1.000 12.29651 ? 246 ASN A O   1 
ATOM   1838 C CB  . ASN A 1 235 ? 9.31951   -3.80017  29.86209  1.000 15.83137 ? 246 ASN A CB  1 
ATOM   1839 C CG  . ASN A 1 235 ? 10.71441  -4.37279  29.62934  1.000 15.84555 ? 246 ASN A CG  1 
ATOM   1840 O OD1 . ASN A 1 235 ? 11.07471  -5.42277  30.18013  1.000 22.22476 ? 246 ASN A OD1 1 
ATOM   1841 N ND2 . ASN A 1 235 ? 11.49905  -3.70108  28.77897  1.000 15.31600 ? 246 ASN A ND2 1 
ATOM   1842 N N   . LEU A 1 236 ? 8.71293   -6.81359  28.77886  1.000 11.72384 ? 247 LEU A N   1 
ATOM   1843 C CA  . LEU A 1 236 ? 8.51876   -8.21118  29.15745  1.000 13.08766 ? 247 LEU A CA  1 
ATOM   1844 C C   . LEU A 1 236 ? 8.70310   -8.41684  30.65177  1.000 12.99385 ? 247 LEU A C   1 
ATOM   1845 O O   . LEU A 1 236 ? 7.97642   -9.20439  31.26899  1.000 14.90709 ? 247 LEU A O   1 
ATOM   1846 C CB  . LEU A 1 236 ? 9.51563   -9.09710  28.42047  1.000 13.95631 ? 247 LEU A CB  1 
ATOM   1847 C CG  . LEU A 1 236 ? 9.24882   -9.36234  26.94512  1.000 11.18665 ? 247 LEU A CG  1 
ATOM   1848 C CD1 . LEU A 1 236 ? 10.33100  -10.31930 26.42842  1.000 12.15650 ? 247 LEU A CD1 1 
ATOM   1849 C CD2 . LEU A 1 236 ? 7.85142   -9.94839  26.73663  1.000 12.59945 ? 247 LEU A CD2 1 
ATOM   1850 N N   . ALA A 1 237 ? 9.69608   -7.75134  31.24079  1.000 11.93201 ? 248 ALA A N   1 
ATOM   1851 C CA  . ALA A 1 237 ? 10.00203  -7.95988  32.65175  1.000 15.23507 ? 248 ALA A CA  1 
ATOM   1852 C C   . ALA A 1 237 ? 8.85586   -7.53736  33.56613  1.000 23.42671 ? 248 ALA A C   1 
ATOM   1853 O O   . ALA A 1 237 ? 8.81495   -7.96479  34.72422  1.000 23.35212 ? 248 ALA A O   1 
ATOM   1854 C CB  . ALA A 1 237 ? 11.30199  -7.24127  33.01605  1.000 19.35713 ? 248 ALA A CB  1 
ATOM   1855 N N   . ASP A 1 238 ? 7.91176   -6.73908  33.07171  1.000 15.68332 ? 249 ASP A N   1 
ATOM   1856 C CA  . ASP A 1 238 ? 6.76060   -6.32366  33.86683  1.000 17.38038 ? 249 ASP A CA  1 
ATOM   1857 C C   . ASP A 1 238 ? 5.56093   -7.26120  33.75076  1.000 21.72475 ? 249 ASP A C   1 
ATOM   1858 O O   . ASP A 1 238 ? 4.58737   -7.08978  34.49417  1.000 20.93975 ? 249 ASP A O   1 
ATOM   1859 C CB  . ASP A 1 238 ? 6.36731   -4.87541  33.54047  1.000 19.85563 ? 249 ASP A CB  1 
ATOM   1860 C CG  . ASP A 1 238 ? 7.50148   -3.89024  33.80866  1.000 25.07387 ? 249 ASP A CG  1 
ATOM   1861 O OD1 . ASP A 1 238 ? 8.22576   -4.05406  34.82395  1.000 27.50778 ? 249 ASP A OD1 1 
ATOM   1862 O OD2 . ASP A 1 238 ? 7.66821   -2.95044  33.00836  1.000 21.67365 ? 249 ASP A OD2 1 
ATOM   1863 N N   . ALA A 1 239 ? 5.60466   -8.24911  32.85537  1.000 16.25957 ? 250 ALA A N   1 
ATOM   1864 C CA  . ALA A 1 239 ? 4.53293   -9.23764  32.78597  1.000 15.51145 ? 250 ALA A CA  1 
ATOM   1865 C C   . ALA A 1 239 ? 4.71394   -10.34554 33.81763  1.000 24.59146 ? 250 ALA A C   1 
ATOM   1866 O O   . ALA A 1 239 ? 3.72777   -10.88685 34.33026  1.000 28.96822 ? 250 ALA A O   1 
ATOM   1867 C CB  . ALA A 1 239 ? 4.52259   -9.89009  31.40134  1.000 16.18928 ? 250 ALA A CB  1 
ATOM   1868 N N   . ASP A 1 240 ? 5.95932   -10.69952 34.11159  1.000 20.11601 ? 251 ASP A N   1 
ATOM   1869 C CA  . ASP A 1 240 ? 6.29231   -11.87554 34.89806  1.000 20.77470 ? 251 ASP A CA  1 
ATOM   1870 C C   . ASP A 1 240 ? 7.78054   -11.75724 35.18056  1.000 27.70341 ? 251 ASP A C   1 
ATOM   1871 O O   . ASP A 1 240 ? 8.57211   -11.55312 34.24971  1.000 24.10604 ? 251 ASP A O   1 
ATOM   1872 C CB  . ASP A 1 240 ? 5.96649   -13.12991 34.07907  1.000 26.05466 ? 251 ASP A CB  1 
ATOM   1873 C CG  . ASP A 1 240 ? 6.16339   -14.43308 34.85259  1.000 39.24448 ? 251 ASP A CG  1 
ATOM   1874 O OD1 . ASP A 1 240 ? 7.23868   -14.63285 35.46372  1.000 29.38662 ? 251 ASP A OD1 1 
ATOM   1875 O OD2 . ASP A 1 240 ? 5.22393   -15.26786 34.83923  1.000 33.33483 ? 251 ASP A OD2 1 
ATOM   1876 N N   . SER A 1 241 ? 8.16694   -11.83167 36.45819  1.000 33.04750 ? 252 SER A N   1 
ATOM   1877 C CA  . SER A 1 241 ? 9.57632   -11.71526 36.81981  1.000 31.42802 ? 252 SER A CA  1 
ATOM   1878 C C   . SER A 1 241 ? 10.42738  -12.78618 36.15113  1.000 31.77499 ? 252 SER A C   1 
ATOM   1879 O O   . SER A 1 241 ? 11.63183  -12.57439 35.95570  1.000 32.43587 ? 252 SER A O   1 
ATOM   1880 C CB  . SER A 1 241 ? 9.73909   -11.77846 38.33935  1.000 27.77255 ? 252 SER A CB  1 
ATOM   1881 O OG  . SER A 1 241 ? 9.10277   -12.93082 38.86438  1.000 43.23400 ? 252 SER A OG  1 
ATOM   1882 N N   . GLY A 1 242 ? 9.82033   -13.91494 35.77018  1.000 28.07421 ? 253 GLY A N   1 
ATOM   1883 C CA  . GLY A 1 242 ? 10.52965  -14.95964 35.05226  1.000 23.65294 ? 253 GLY A CA  1 
ATOM   1884 C C   . GLY A 1 242 ? 11.00900  -14.56082 33.67152  1.000 21.47112 ? 253 GLY A C   1 
ATOM   1885 O O   . GLY A 1 242 ? 11.86410  -15.25176 33.10644  1.000 19.22140 ? 253 GLY A O   1 
ATOM   1886 N N   . LEU A 1 243 ? 10.48503  -13.46652 33.11388  1.000 17.52238 ? 254 LEU A N   1 
ATOM   1887 C CA  . LEU A 1 243 ? 10.88389  -13.04305 31.77408  1.000 14.96939 ? 254 LEU A CA  1 
ATOM   1888 C C   . LEU A 1 243 ? 12.16256  -12.21357 31.76064  1.000 20.25135 ? 254 LEU A C   1 
ATOM   1889 O O   . LEU A 1 243 ? 12.62423  -11.84082 30.67521  1.000 15.43059 ? 254 LEU A O   1 
ATOM   1890 C CB  . LEU A 1 243 ? 9.73719   -12.31837 31.06078  1.000 13.80566 ? 254 LEU A CB  1 
ATOM   1891 C CG  . LEU A 1 243 ? 8.45106   -13.12197 30.83830  1.000 9.67828  ? 254 LEU A CG  1 
ATOM   1892 C CD1 . LEU A 1 243 ? 7.46462   -12.36158 29.95691  1.000 16.21494 ? 254 LEU A CD1 1 
ATOM   1893 C CD2 . LEU A 1 243 ? 8.78467   -14.48358 30.23161  1.000 14.48847 ? 254 LEU A CD2 1 
ATOM   1894 N N   . GLN A 1 244 ? 12.75744  -11.92049 32.92244  1.000 18.19726 ? 255 GLN A N   1 
ATOM   1895 C CA  . GLN A 1 244 ? 14.05635  -11.25416 32.91225  1.000 14.79964 ? 255 GLN A CA  1 
ATOM   1896 C C   . GLN A 1 244 ? 15.11366  -12.10167 32.20957  1.000 16.50157 ? 255 GLN A C   1 
ATOM   1897 O O   . GLN A 1 244 ? 16.01918  -11.55239 31.56886  1.000 20.57903 ? 255 GLN A O   1 
ATOM   1898 C CB  . GLN A 1 244 ? 14.49880  -10.87828 34.33093  1.000 24.14284 ? 255 GLN A CB  1 
ATOM   1899 C CG  . GLN A 1 244 ? 15.78409  -10.04095 34.37459  1.000 25.45006 ? 255 GLN A CG  1 
ATOM   1900 C CD  . GLN A 1 244 ? 15.65577  -8.71772  33.62388  1.000 27.14789 ? 255 GLN A CD  1 
ATOM   1901 O OE1 . GLN A 1 244 ? 14.70329  -7.97096  33.83126  1.000 26.58771 ? 255 GLN A OE1 1 
ATOM   1902 N NE2 . GLN A 1 244 ? 16.62553  -8.41943  32.75850  1.000 23.69916 ? 255 GLN A NE2 1 
ATOM   1903 N N   . SER A 1 245 ? 15.00978  -13.43529 32.30174  1.000 16.68792 ? 256 SER A N   1 
ATOM   1904 C CA  A SER A 1 245 ? 15.94302  -14.29476 31.58075  0.336 17.61058 ? 256 SER A CA  1 
ATOM   1905 C CA  B SER A 1 245 ? 15.92825  -14.31147 31.57861  0.664 17.58031 ? 256 SER A CA  1 
ATOM   1906 C C   . SER A 1 245 ? 15.81100  -14.12432 30.07382  1.000 13.39495 ? 256 SER A C   1 
ATOM   1907 O O   . SER A 1 245 ? 16.80466  -14.26220 29.34420  1.000 16.36232 ? 256 SER A O   1 
ATOM   1908 C CB  A SER A 1 245 ? 15.71949  -15.75736 31.96471  0.336 19.30438 ? 256 SER A CB  1 
ATOM   1909 C CB  B SER A 1 245 ? 15.63854  -15.77146 31.93807  0.664 19.24233 ? 256 SER A CB  1 
ATOM   1910 O OG  A SER A 1 245 ? 14.33981  -16.03188 32.09532  0.336 18.58686 ? 256 SER A OG  1 
ATOM   1911 O OG  B SER A 1 245 ? 15.98856  -16.03387 33.28260  0.664 21.66318 ? 256 SER A OG  1 
ATOM   1912 N N   . VAL A 1 246 ? 14.60206  -13.85099 29.58687  1.000 13.16375 ? 257 VAL A N   1 
ATOM   1913 C CA  . VAL A 1 246 ? 14.42090  -13.62912 28.15776  1.000 13.59717 ? 257 VAL A CA  1 
ATOM   1914 C C   . VAL A 1 246 ? 15.05539  -12.30600 27.74891  1.000 13.28578 ? 257 VAL A C   1 
ATOM   1915 O O   . VAL A 1 246 ? 15.75333  -12.22812 26.73326  1.000 10.87546 ? 257 VAL A O   1 
ATOM   1916 C CB  . VAL A 1 246 ? 12.92857  -13.69143 27.78309  1.000 13.00874 ? 257 VAL A CB  1 
ATOM   1917 C CG1 . VAL A 1 246 ? 12.73442  -13.28517 26.33127  1.000 13.25640 ? 257 VAL A CG1 1 
ATOM   1918 C CG2 . VAL A 1 246 ? 12.36261  -15.08736 28.06410  1.000 16.06256 ? 257 VAL A CG2 1 
ATOM   1919 N N   . VAL A 1 247 ? 14.84549  -11.25613 28.55159  1.000 12.11599 ? 258 VAL A N   1 
ATOM   1920 C CA  . VAL A 1 247 ? 15.40620  -9.93982  28.24484  1.000 9.41403  ? 258 VAL A CA  1 
ATOM   1921 C C   . VAL A 1 247 ? 16.92983  -9.99725  28.23202  1.000 11.92381 ? 258 VAL A C   1 
ATOM   1922 O O   . VAL A 1 247 ? 17.58039  -9.39923  27.36287  1.000 12.34468 ? 258 VAL A O   1 
ATOM   1923 C CB  . VAL A 1 247 ? 14.87988  -8.89022  29.24223  1.000 13.30414 ? 258 VAL A CB  1 
ATOM   1924 C CG1 . VAL A 1 247 ? 15.54315  -7.54414  28.99449  1.000 15.93687 ? 258 VAL A CG1 1 
ATOM   1925 C CG2 . VAL A 1 247 ? 13.37417  -8.76405  29.14006  1.000 14.10154 ? 258 VAL A CG2 1 
ATOM   1926 N N   . ASP A 1 248 ? 17.51903  -10.74653 29.17373  1.000 14.79725 ? 259 ASP A N   1 
ATOM   1927 C CA  . ASP A 1 248 ? 18.96900  -10.93052 29.18101  1.000 15.67551 ? 259 ASP A CA  1 
ATOM   1928 C C   . ASP A 1 248 ? 19.47245  -11.55442 27.88030  1.000 16.49263 ? 259 ASP A C   1 
ATOM   1929 O O   . ASP A 1 248 ? 20.48628  -11.11393 27.32968  1.000 14.74448 ? 259 ASP A O   1 
ATOM   1930 C CB  . ASP A 1 248 ? 19.40414  -11.76268 30.39163  1.000 24.53903 ? 259 ASP A CB  1 
ATOM   1931 C CG  . ASP A 1 248 ? 19.12320  -11.07018 31.72021  1.000 32.20098 ? 259 ASP A CG  1 
ATOM   1932 O OD1 . ASP A 1 248 ? 18.84405  -9.85283  31.72443  1.000 33.84141 ? 259 ASP A OD1 1 
ATOM   1933 O OD2 . ASP A 1 248 ? 19.17845  -11.75311 32.76390  1.000 40.52256 ? 259 ASP A OD2 1 
ATOM   1934 N N   . ALA A 1 249 ? 18.77672  -12.57711 27.37326  1.000 13.88033 ? 260 ALA A N   1 
ATOM   1935 C CA  . ALA A 1 249 ? 19.17864  -13.22030 26.12341  1.000 11.78525 ? 260 ALA A CA  1 
ATOM   1936 C C   . ALA A 1 249 ? 19.10059  -12.24760 24.95030  1.000 11.74257 ? 260 ALA A C   1 
ATOM   1937 O O   . ALA A 1 249 ? 19.99464  -12.21793 24.09498  1.000 11.39302 ? 260 ALA A O   1 
ATOM   1938 C CB  . ALA A 1 249 ? 18.27678  -14.43282 25.85919  1.000 12.94857 ? 260 ALA A CB  1 
ATOM   1939 N N   . LEU A 1 250 ? 18.04274  -11.42994 24.90605  1.000 11.16515 ? 261 LEU A N   1 
ATOM   1940 C CA  . LEU A 1 250 ? 17.84761  -10.51183 23.78704  1.000 10.54693 ? 261 LEU A CA  1 
ATOM   1941 C C   . LEU A 1 250 ? 18.99522  -9.52281  23.65812  1.000 13.91468 ? 261 LEU A C   1 
ATOM   1942 O O   . LEU A 1 250 ? 19.29717  -9.06267  22.55225  1.000 16.72153 ? 261 LEU A O   1 
ATOM   1943 C CB  . LEU A 1 250 ? 16.55325  -9.72901  23.99444  1.000 10.24544 ? 261 LEU A CB  1 
ATOM   1944 C CG  . LEU A 1 250 ? 15.24408  -10.50097 24.03615  1.000 11.67987 ? 261 LEU A CG  1 
ATOM   1945 C CD1 . LEU A 1 250 ? 14.11477  -9.53153  24.38130  1.000 16.69319 ? 261 LEU A CD1 1 
ATOM   1946 C CD2 . LEU A 1 250 ? 14.96779  -11.20849 22.71105  1.000 14.72071 ? 261 LEU A CD2 1 
ATOM   1947 N N   . GLY A 1 251 ? 19.63840  -9.17307  24.76888  1.000 16.53460 ? 262 GLY A N   1 
ATOM   1948 C CA  . GLY A 1 251 ? 20.75332  -8.25177  24.69666  1.000 19.41249 ? 262 GLY A CA  1 
ATOM   1949 C C   . GLY A 1 251 ? 22.11450  -8.87515  24.50497  1.000 25.43384 ? 262 GLY A C   1 
ATOM   1950 O O   . GLY A 1 251 ? 23.11496  -8.15214  24.47570  1.000 23.96735 ? 262 GLY A O   1 
ATOM   1951 N N   . ASN A 1 252 ? 22.18531  -10.20005 24.37160  1.000 17.02174 ? 263 ASN A N   1 
ATOM   1952 C CA  . ASN A 1 252 ? 23.43349  -10.93448 24.20481  1.000 17.58768 ? 263 ASN A CA  1 
ATOM   1953 C C   . ASN A 1 252 ? 23.40047  -11.57615 22.82232  1.000 17.87550 ? 263 ASN A C   1 
ATOM   1954 O O   . ASN A 1 252 ? 22.68873  -12.56569 22.60951  1.000 19.64357 ? 263 ASN A O   1 
ATOM   1955 C CB  . ASN A 1 252 ? 23.56414  -11.99718 25.29376  1.000 21.97338 ? 263 ASN A CB  1 
ATOM   1956 C CG  . ASN A 1 252 ? 24.88801  -12.74088 25.23522  1.000 24.44992 ? 263 ASN A CG  1 
ATOM   1957 O OD1 . ASN A 1 252 ? 25.68534  -12.55216 24.31478  1.000 26.95499 ? 263 ASN A OD1 1 
ATOM   1958 N ND2 . ASN A 1 252 ? 25.11851  -13.60867 26.21553  1.000 28.31437 ? 263 ASN A ND2 1 
ATOM   1959 N N   . GLU A 1 253 ? 24.18786  -11.02223 21.89658  1.000 20.29308 ? 264 GLU A N   1 
ATOM   1960 C CA  . GLU A 1 253 ? 24.20951  -11.49922 20.51288  1.000 26.17559 ? 264 GLU A CA  1 
ATOM   1961 C C   . GLU A 1 253 ? 24.62110  -12.96574 20.40899  1.000 20.68025 ? 264 GLU A C   1 
ATOM   1962 O O   . GLU A 1 253 ? 24.18427  -13.67029 19.48790  1.000 18.83604 ? 264 GLU A O   1 
ATOM   1963 C CB  . GLU A 1 253 ? 25.15054  -10.60901 19.68974  1.000 30.21189 ? 264 GLU A CB  1 
ATOM   1964 C CG  . GLU A 1 253 ? 25.56315  -11.13079 18.30613  1.000 42.36078 ? 264 GLU A CG  1 
ATOM   1965 C CD  . GLU A 1 253 ? 24.39641  -11.59513 17.44501  1.000 56.23605 ? 264 GLU A CD  1 
ATOM   1966 O OE1 . GLU A 1 253 ? 23.36391  -10.88981 17.40519  1.000 57.53329 ? 264 GLU A OE1 1 
ATOM   1967 O OE2 . GLU A 1 253 ? 24.51757  -12.66734 16.80528  1.000 43.16201 ? 264 GLU A OE2 1 
ATOM   1968 N N   . GLN A 1 254 ? 25.45244  -13.45294 21.33365  1.000 18.33450 ? 265 GLN A N   1 
ATOM   1969 C CA  . GLN A 1 254 ? 25.87478  -14.84497 21.25508  1.000 17.42409 ? 265 GLN A CA  1 
ATOM   1970 C C   . GLN A 1 254 ? 24.74678  -15.82657 21.54590  1.000 15.93818 ? 265 GLN A C   1 
ATOM   1971 O O   . GLN A 1 254 ? 24.89324  -17.01004 21.24247  1.000 18.10923 ? 265 GLN A O   1 
ATOM   1972 C CB  . GLN A 1 254 ? 27.08064  -15.11862 22.16544  1.000 23.87395 ? 265 GLN A CB  1 
ATOM   1973 C CG  . GLN A 1 254 ? 28.11032  -13.99074 22.16544  1.000 32.28009 ? 265 GLN A CG  1 
ATOM   1974 C CD  . GLN A 1 254 ? 29.48967  -14.43356 22.62877  1.000 35.08104 ? 265 GLN A CD  1 
ATOM   1975 O OE1 . GLN A 1 254 ? 29.79697  -15.62601 22.67889  1.000 41.80150 ? 265 GLN A OE1 1 
ATOM   1976 N NE2 . GLN A 1 254 ? 30.32814  -13.46878 22.96452  1.000 23.34444 ? 265 GLN A NE2 1 
ATOM   1977 N N   . THR A 1 255 ? 23.62818  -15.37111 22.09762  1.000 11.27947 ? 266 THR A N   1 
ATOM   1978 C CA  . THR A 1 255 ? 22.50967  -16.27194 22.34501  1.000 9.92021  ? 266 THR A CA  1 
ATOM   1979 C C   . THR A 1 255 ? 21.49114  -16.28568 21.21155  1.000 10.58167 ? 266 THR A C   1 
ATOM   1980 O O   . THR A 1 255 ? 20.51475  -17.04303 21.28746  1.000 11.83941 ? 266 THR A O   1 
ATOM   1981 C CB  . THR A 1 255 ? 21.83402  -15.97367 23.69326  1.000 15.39478 ? 266 THR A CB  1 
ATOM   1982 O OG1 . THR A 1 255 ? 20.93664  -14.86046 23.56455  1.000 17.85646 ? 266 THR A OG1 1 
ATOM   1983 C CG2 . THR A 1 255 ? 22.88965  -15.67641 24.75912  1.000 17.07680 ? 266 THR A CG2 1 
ATOM   1984 N N   . GLU A 1 256 ? 21.69468  -15.48361 20.17002  1.000 9.65720  ? 267 GLU A N   1 
ATOM   1985 C CA  . GLU A 1 256 ? 20.80485  -15.53064 19.01491  1.000 12.08077 ? 267 GLU A CA  1 
ATOM   1986 C C   . GLU A 1 256 ? 20.75153  -16.93161 18.42860  1.000 9.64178  ? 267 GLU A C   1 
ATOM   1987 O O   . GLU A 1 256 ? 21.77747  -17.60136 18.29227  1.000 10.78872 ? 267 GLU A O   1 
ATOM   1988 C CB  . GLU A 1 256 ? 21.28936  -14.58266 17.91843  1.000 12.86492 ? 267 GLU A CB  1 
ATOM   1989 C CG  . GLU A 1 256 ? 20.16211  -14.19346 16.96878  1.000 15.27246 ? 267 GLU A CG  1 
ATOM   1990 C CD  . GLU A 1 256 ? 20.38383  -12.86211 16.27806  1.000 25.89568 ? 267 GLU A CD  1 
ATOM   1991 O OE1 . GLU A 1 256 ? 20.23465  -12.81125 15.03949  1.000 35.97181 ? 267 GLU A OE1 1 
ATOM   1992 O OE2 . GLU A 1 256 ? 20.72605  -11.87663 16.97369  1.000 44.01155 ? 267 GLU A OE2 1 
ATOM   1993 N N   . GLU A 1 257 ? 19.53839  -17.36298 18.06623  1.000 7.68306  ? 268 GLU A N   1 
ATOM   1994 C CA  . GLU A 1 257 ? 19.31567  -18.64152 17.37945  1.000 8.63393  ? 268 GLU A CA  1 
ATOM   1995 C C   . GLU A 1 257 ? 19.79973  -19.84011 18.19436  1.000 11.44824 ? 268 GLU A C   1 
ATOM   1996 O O   . GLU A 1 257 ? 20.19103  -20.86763 17.64148  1.000 12.01675 ? 268 GLU A O   1 
ATOM   1997 C CB  . GLU A 1 257 ? 19.88874  -18.61724 15.95729  1.000 12.26461 ? 268 GLU A CB  1 
ATOM   1998 C CG  . GLU A 1 257 ? 19.13856  -17.59816 15.09922  1.000 13.64044 ? 268 GLU A CG  1 
ATOM   1999 C CD  . GLU A 1 257 ? 19.86385  -17.23783 13.81670  1.000 18.26776 ? 268 GLU A CD  1 
ATOM   2000 O OE1 . GLU A 1 257 ? 20.12373  -18.15090 13.02790  1.000 16.44670 ? 268 GLU A OE1 1 
ATOM   2001 O OE2 . GLU A 1 257 ? 20.14378  -16.04082 13.58414  1.000 18.45738 ? 268 GLU A OE2 1 
ATOM   2002 N N   . THR A 1 258 ? 19.76139  -19.72094 19.51828  1.000 8.85460  ? 269 THR A N   1 
ATOM   2003 C CA  . THR A 1 258 ? 20.02394  -20.82583 20.43021  1.000 10.21789 ? 269 THR A CA  1 
ATOM   2004 C C   . THR A 1 258 ? 18.81716  -21.01668 21.34339  1.000 9.28847  ? 269 THR A C   1 
ATOM   2005 O O   . THR A 1 258 ? 18.02709  -20.09446 21.56481  1.000 9.28441  ? 269 THR A O   1 
ATOM   2006 C CB  . THR A 1 258 ? 21.28569  -20.58731 21.27962  1.000 11.30615 ? 269 THR A CB  1 
ATOM   2007 O OG1 . THR A 1 258 ? 21.00890  -19.62925 22.30230  1.000 15.54982 ? 269 THR A OG1 1 
ATOM   2008 C CG2 . THR A 1 258 ? 22.43581  -20.07534 20.42022  1.000 11.55802 ? 269 THR A CG2 1 
ATOM   2009 N N   . ALA A 1 259 ? 18.69236  -22.22075 21.90038  1.000 6.76055  ? 270 ALA A N   1 
ATOM   2010 C CA  . ALA A 1 259 ? 17.57560  -22.52717 22.78757  1.000 7.27652  ? 270 ALA A CA  1 
ATOM   2011 C C   . ALA A 1 259 ? 17.76234  -21.81643 24.12597  1.000 9.81011  ? 270 ALA A C   1 
ATOM   2012 O O   . ALA A 1 259 ? 18.78326  -22.00315 24.79602  1.000 12.29002 ? 270 ALA A O   1 
ATOM   2013 C CB  . ALA A 1 259 ? 17.48081  -24.03690 22.99198  1.000 9.16570  ? 270 ALA A CB  1 
ATOM   2014 N N   . VAL A 1 260 ? 16.78314  -20.99224 24.50817  1.000 7.49186  ? 271 VAL A N   1 
ATOM   2015 C CA  . VAL A 1 260 ? 16.79809  -20.27393 25.78444  1.000 8.17088  ? 271 VAL A CA  1 
ATOM   2016 C C   . VAL A 1 260 ? 15.63659  -20.78390 26.62927  1.000 8.75910  ? 271 VAL A C   1 
ATOM   2017 O O   . VAL A 1 260 ? 14.47421  -20.68846 26.21126  1.000 9.00086  ? 271 VAL A O   1 
ATOM   2018 C CB  . VAL A 1 260 ? 16.71898  -18.74896 25.58630  1.000 8.39947  ? 271 VAL A CB  1 
ATOM   2019 C CG1 . VAL A 1 260 ? 16.65602  -18.02655 26.94588  1.000 10.97738 ? 271 VAL A CG1 1 
ATOM   2020 C CG2 . VAL A 1 260 ? 17.89436  -18.26243 24.76121  1.000 10.52472 ? 271 VAL A CG2 1 
ATOM   2021 N N   . SER A 1 261 ? 15.94348  -21.30096 27.82402  1.000 9.19015  ? 272 SER A N   1 
ATOM   2022 C CA  . SER A 1 261 ? 14.92525  -21.82243 28.73348  1.000 7.89459  ? 272 SER A CA  1 
ATOM   2023 C C   . SER A 1 261 ? 14.50569  -20.74753 29.73106  1.000 8.82123  ? 272 SER A C   1 
ATOM   2024 O O   . SER A 1 261 ? 15.33061  -19.95009 30.20361  1.000 10.96350 ? 272 SER A O   1 
ATOM   2025 C CB  . SER A 1 261 ? 15.44399  -23.04184 29.51006  1.000 9.87761  ? 272 SER A CB  1 
ATOM   2026 O OG  . SER A 1 261 ? 15.69979  -24.13920 28.65503  1.000 16.69139 ? 272 SER A OG  1 
ATOM   2027 N N   . TYR A 1 262 ? 13.21428  -20.73820 30.05320  1.000 6.69915  ? 273 TYR A N   1 
ATOM   2028 C CA  . TYR A 1 262 ? 12.65711  -19.82109 31.03749  1.000 7.58200  ? 273 TYR A CA  1 
ATOM   2029 C C   . TYR A 1 262 ? 11.34172  -20.41011 31.54072  1.000 7.49869  ? 273 TYR A C   1 
ATOM   2030 O O   . TYR A 1 262 ? 10.90912  -21.47784 31.10089  1.000 10.80013 ? 273 TYR A O   1 
ATOM   2031 C CB  . TYR A 1 262 ? 12.48679  -18.41506 30.45092  1.000 9.52380  ? 273 TYR A CB  1 
ATOM   2032 C CG  . TYR A 1 262 ? 11.45951  -18.29275 29.32908  1.000 6.41656  ? 273 TYR A CG  1 
ATOM   2033 C CD1 . TYR A 1 262 ? 11.74613  -18.72838 28.04119  1.000 8.69146  ? 273 TYR A CD1 1 
ATOM   2034 C CD2 . TYR A 1 262 ? 10.21428  -17.69942 29.55653  1.000 8.01095  ? 273 TYR A CD2 1 
ATOM   2035 C CE1 . TYR A 1 262 ? 10.81352  -18.59261 27.01844  1.000 7.70862  ? 273 TYR A CE1 1 
ATOM   2036 C CE2 . TYR A 1 262 ? 9.28251   -17.55410 28.53951  1.000 6.13200  ? 273 TYR A CE2 1 
ATOM   2037 C CZ  . TYR A 1 262 ? 9.58606   -18.00633 27.27130  1.000 8.25183  ? 273 TYR A CZ  1 
ATOM   2038 O OH  . TYR A 1 262 ? 8.66540   -17.85050 26.24928  1.000 10.85277 ? 273 TYR A OH  1 
ATOM   2039 N N   . THR A 1 263 ? 10.73942  -19.73510 32.52412  1.000 7.92227  ? 274 THR A N   1 
ATOM   2040 C CA  . THR A 1 263 ? 9.47641   -20.14962 33.11794  1.000 8.64128  ? 274 THR A CA  1 
ATOM   2041 C C   . THR A 1 263 ? 8.51969   -18.96743 33.07012  1.000 11.22948 ? 274 THR A C   1 
ATOM   2042 O O   . THR A 1 263 ? 8.90145   -17.83532 33.38459  1.000 15.41499 ? 274 THR A O   1 
ATOM   2043 C CB  . THR A 1 263 ? 9.67622   -20.65372 34.56538  1.000 12.76699 ? 274 THR A CB  1 
ATOM   2044 O OG1 . THR A 1 263 ? 10.67405  -21.68426 34.58626  1.000 12.89797 ? 274 THR A OG1 1 
ATOM   2045 C CG2 . THR A 1 263 ? 8.37987   -21.21874 35.14909  1.000 16.46519 ? 274 THR A CG2 1 
ATOM   2046 N N   . TYR A 1 264 ? 7.27729   -19.23392 32.67610  1.000 10.48264 ? 275 TYR A N   1 
ATOM   2047 C CA  . TYR A 1 264 ? 6.29629   -18.17255 32.47463  1.000 11.50424 ? 275 TYR A CA  1 
ATOM   2048 C C   . TYR A 1 264 ? 4.90801   -18.73485 32.73029  1.000 13.90022 ? 275 TYR A C   1 
ATOM   2049 O O   . TYR A 1 264 ? 4.55246   -19.77605 32.17051  1.000 11.56650 ? 275 TYR A O   1 
ATOM   2050 C CB  . TYR A 1 264 ? 6.39599   -17.64000 31.03765  1.000 10.12392 ? 275 TYR A CB  1 
ATOM   2051 C CG  . TYR A 1 264 ? 5.41087   -16.55584 30.67791  1.000 14.92185 ? 275 TYR A CG  1 
ATOM   2052 C CD1 . TYR A 1 264 ? 5.42364   -15.33299 31.34612  1.000 21.87488 ? 275 TYR A CD1 1 
ATOM   2053 C CD2 . TYR A 1 264 ? 4.47567   -16.74652 29.65785  1.000 16.02332 ? 275 TYR A CD2 1 
ATOM   2054 C CE1 . TYR A 1 264 ? 4.53242   -14.33545 31.01711  1.000 19.37974 ? 275 TYR A CE1 1 
ATOM   2055 C CE2 . TYR A 1 264 ? 3.57731   -15.74423 29.31699  1.000 21.75073 ? 275 TYR A CE2 1 
ATOM   2056 C CZ  . TYR A 1 264 ? 3.61634   -14.54236 30.00376  1.000 23.53999 ? 275 TYR A CZ  1 
ATOM   2057 O OH  . TYR A 1 264 ? 2.72318   -13.54295 29.68022  1.000 32.05482 ? 275 TYR A OH  1 
ATOM   2058 N N   . GLN A 1 265 ? 4.14659   -18.05333 33.59318  1.000 14.47718 ? 276 GLN A N   1 
ATOM   2059 C CA  . GLN A 1 265 ? 2.76881   -18.44378 33.90797  1.000 15.33303 ? 276 GLN A CA  1 
ATOM   2060 C C   . GLN A 1 265 ? 2.65758   -19.93282 34.24527  1.000 15.75282 ? 276 GLN A C   1 
ATOM   2061 O O   . GLN A 1 265 ? 1.76727   -20.64420 33.77428  1.000 16.31491 ? 276 GLN A O   1 
ATOM   2062 C CB  . GLN A 1 265 ? 1.81987   -18.04447 32.78229  1.000 24.14030 ? 276 GLN A CB  1 
ATOM   2063 C CG  . GLN A 1 265 ? 1.69151   -16.54135 32.64942  1.000 20.45716 ? 276 GLN A CG  1 
ATOM   2064 C CD  . GLN A 1 265 ? 0.71750   -16.12692 31.56770  1.000 38.40121 ? 276 GLN A CD  1 
ATOM   2065 O OE1 . GLN A 1 265 ? 0.28311   -16.94688 30.75771  1.000 34.33991 ? 276 GLN A OE1 1 
ATOM   2066 N NE2 . GLN A 1 265 ? 0.37952   -14.84252 31.53858  1.000 34.98769 ? 276 GLN A NE2 1 
ATOM   2067 N N   . GLY A 1 266 ? 3.59189   -20.40447 35.06433  1.000 14.71638 ? 277 GLY A N   1 
ATOM   2068 C CA  . GLY A 1 266 ? 3.53538   -21.75676 35.57886  1.000 17.07028 ? 277 GLY A CA  1 
ATOM   2069 C C   . GLY A 1 266 ? 4.06834   -22.84713 34.67582  1.000 17.15232 ? 277 GLY A C   1 
ATOM   2070 O O   . GLY A 1 266 ? 3.93814   -24.02513 35.02314  1.000 14.98772 ? 277 GLY A O   1 
ATOM   2071 N N   . LYS A 1 267 ? 4.65487   -22.51412 33.52245  1.000 13.83646 ? 278 LYS A N   1 
ATOM   2072 C CA  . LYS A 1 267 ? 5.18267   -23.53037 32.62152  1.000 11.09255 ? 278 LYS A CA  1 
ATOM   2073 C C   . LYS A 1 267 ? 6.62865   -23.21943 32.27336  1.000 9.24718  ? 278 LYS A C   1 
ATOM   2074 O O   . LYS A 1 267 ? 6.98097   -22.06484 32.00470  1.000 9.79846  ? 278 LYS A O   1 
ATOM   2075 C CB  . LYS A 1 267 ? 4.40951   -23.59557 31.28150  1.000 10.25173 ? 278 LYS A CB  1 
ATOM   2076 C CG  . LYS A 1 267 ? 2.97759   -24.09027 31.39406  1.000 12.92918 ? 278 LYS A CG  1 
ATOM   2077 C CD  . LYS A 1 267 ? 2.31042   -24.08685 30.02256  1.000 14.51077 ? 278 LYS A CD  1 
ATOM   2078 C CE  . LYS A 1 267 ? 0.81579   -24.28947 30.17448  1.000 18.66137 ? 278 LYS A CE  1 
ATOM   2079 N NZ  . LYS A 1 267 ? 0.16700   -24.53396 28.85071  1.000 16.38307 ? 278 LYS A NZ  1 
ATOM   2080 N N   . ASP A 1 268 ? 7.44182   -24.26806 32.21895  1.000 9.22503  ? 279 ASP A N   1 
ATOM   2081 C CA  . ASP A 1 268 ? 8.75388   -24.16362 31.59965  1.000 9.28793  ? 279 ASP A CA  1 
ATOM   2082 C C   . ASP A 1 268 ? 8.56534   -23.99530 30.09759  1.000 9.05951  ? 279 ASP A C   1 
ATOM   2083 O O   . ASP A 1 268 ? 7.75337   -24.69098 29.47650  1.000 8.54819  ? 279 ASP A O   1 
ATOM   2084 C CB  . ASP A 1 268 ? 9.54469   -25.44586 31.85069  1.000 8.54563  ? 279 ASP A CB  1 
ATOM   2085 C CG  . ASP A 1 268 ? 10.14127  -25.51801 33.26223  1.000 13.89760 ? 279 ASP A CG  1 
ATOM   2086 O OD1 . ASP A 1 268 ? 10.07691  -24.52045 34.02017  1.000 15.22462 ? 279 ASP A OD1 1 
ATOM   2087 O OD2 . ASP A 1 268 ? 10.67453  -26.59138 33.60822  1.000 15.68428 ? 279 ASP A OD2 1 
ATOM   2088 N N   . LYS A 1 269 ? 9.30707   -23.05878 29.51503  1.000 6.63753  ? 280 LYS A N   1 
ATOM   2089 C CA  . LYS A 1 269 ? 9.21412   -22.77177 28.08801  1.000 6.00683  ? 280 LYS A CA  1 
ATOM   2090 C C   . LYS A 1 269 ? 10.60705  -22.74060 27.48387  1.000 7.57007  ? 280 LYS A C   1 
ATOM   2091 O O   . LYS A 1 269 ? 11.61968  -22.61325 28.18244  1.000 7.13735  ? 280 LYS A O   1 
ATOM   2092 C CB  . LYS A 1 269 ? 8.53421   -21.40524 27.87536  1.000 6.50962  ? 280 LYS A CB  1 
ATOM   2093 C CG  . LYS A 1 269 ? 7.09502   -21.37281 28.44499  1.000 9.64880  ? 280 LYS A CG  1 
ATOM   2094 C CD  . LYS A 1 269 ? 6.24626   -20.20456 27.91221  1.000 8.89172  ? 280 LYS A CD  1 
ATOM   2095 C CE  . LYS A 1 269 ? 5.73332   -20.51829 26.51055  1.000 9.29992  ? 280 LYS A CE  1 
ATOM   2096 N NZ  . LYS A 1 269 ? 4.89011   -19.39020 25.98160  1.000 12.13269 ? 280 LYS A NZ  1 
ATOM   2097 N N   . VAL A 1 270 ? 10.64205  -22.86289 26.15705  1.000 7.35460  ? 281 VAL A N   1 
ATOM   2098 C CA  . VAL A 1 270 ? 11.87657  -22.74603 25.39084  1.000 7.23797  ? 281 VAL A CA  1 
ATOM   2099 C C   . VAL A 1 270 ? 11.61377  -21.77288 24.26060  1.000 7.07159  ? 281 VAL A C   1 
ATOM   2100 O O   . VAL A 1 270 ? 10.56532  -21.83721 23.61698  1.000 8.41840  ? 281 VAL A O   1 
ATOM   2101 C CB  . VAL A 1 270 ? 12.29345  -24.11539 24.80829  1.000 9.00844  ? 281 VAL A CB  1 
ATOM   2102 C CG1 . VAL A 1 270 ? 13.51304  -23.97514 23.89032  1.000 11.47336 ? 281 VAL A CG1 1 
ATOM   2103 C CG2 . VAL A 1 270 ? 12.54676  -25.11880 25.92080  1.000 13.00973 ? 281 VAL A CG2 1 
ATOM   2104 N N   . MET A 1 271 ? 12.55694  -20.87346 24.00683  1.000 6.70147  ? 282 MET A N   1 
ATOM   2105 C CA  A MET A 1 271 ? 12.42465  -19.96513 22.88078  0.602 6.19928  ? 282 MET A CA  1 
ATOM   2106 C CA  B MET A 1 271 ? 12.43418  -19.93377 22.90315  0.398 6.21276  ? 282 MET A CA  1 
ATOM   2107 C C   . MET A 1 271 ? 13.70815  -19.91450 22.06989  1.000 7.76700  ? 282 MET A C   1 
ATOM   2108 O O   . MET A 1 271 ? 14.79164  -20.24784 22.54815  1.000 6.75501  ? 282 MET A O   1 
ATOM   2109 C CB  A MET A 1 271 ? 12.00031  -18.55701 23.30503  0.602 8.83903  ? 282 MET A CB  1 
ATOM   2110 C CB  B MET A 1 271 ? 12.14813  -18.52583 23.42191  0.398 9.01744  ? 282 MET A CB  1 
ATOM   2111 C CG  A MET A 1 271 ? 13.07236  -17.82986 24.07191  0.602 8.53858  ? 282 MET A CG  1 
ATOM   2112 C CG  B MET A 1 271 ? 13.27020  -17.98806 24.27958  0.398 9.37435  ? 282 MET A CG  1 
ATOM   2113 S SD  A MET A 1 271 ? 14.21553  -16.97322 22.98137  0.602 10.14484 ? 282 MET A SD  1 
ATOM   2114 S SD  B MET A 1 271 ? 13.08897  -16.25224 24.66507  0.398 18.49902 ? 282 MET A SD  1 
ATOM   2115 C CE  A MET A 1 271 ? 14.51851  -15.49678 23.94609  0.602 15.67554 ? 282 MET A CE  1 
ATOM   2116 C CE  B MET A 1 271 ? 14.48940  -15.55850 23.79842  0.398 15.41179 ? 282 MET A CE  1 
ATOM   2117 N N   . TYR A 1 272 ? 13.55225  -19.48118 20.81755  1.000 6.45271  ? 283 TYR A N   1 
ATOM   2118 C CA  . TYR A 1 272 ? 14.65065  -19.11217 19.93715  1.000 5.97759  ? 283 TYR A CA  1 
ATOM   2119 C C   . TYR A 1 272 ? 14.31885  -17.72245 19.42134  1.000 6.50828  ? 283 TYR A C   1 
ATOM   2120 O O   . TYR A 1 272 ? 13.15672  -17.43746 19.12917  1.000 7.38475  ? 283 TYR A O   1 
ATOM   2121 C CB  . TYR A 1 272 ? 14.69779  -20.04104 18.70839  1.000 7.20754  ? 283 TYR A CB  1 
ATOM   2122 C CG  . TYR A 1 272 ? 15.33198  -21.38506 18.97060  1.000 5.56052  ? 283 TYR A CG  1 
ATOM   2123 C CD1 . TYR A 1 272 ? 14.65535  -22.35967 19.69413  1.000 8.60918  ? 283 TYR A CD1 1 
ATOM   2124 C CD2 . TYR A 1 272 ? 16.61323  -21.66806 18.51581  1.000 8.30050  ? 283 TYR A CD2 1 
ATOM   2125 C CE1 . TYR A 1 272 ? 15.23491  -23.60641 19.94647  1.000 10.07745 ? 283 TYR A CE1 1 
ATOM   2126 C CE2 . TYR A 1 272 ? 17.20050  -22.90227 18.75705  1.000 8.95751  ? 283 TYR A CE2 1 
ATOM   2127 C CZ  . TYR A 1 272 ? 16.51196  -23.85856 19.47793  1.000 9.75330  ? 283 TYR A CZ  1 
ATOM   2128 O OH  . TYR A 1 272 ? 17.07887  -25.09566 19.72992  1.000 13.81590 ? 283 TYR A OH  1 
ATOM   2129 N N   . TYR A 1 273 ? 15.31939  -16.84865 19.29805  1.000 5.85668  ? 284 TYR A N   1 
ATOM   2130 C CA  . TYR A 1 273 ? 15.07644  -15.53403 18.71786  1.000 4.98283  ? 284 TYR A CA  1 
ATOM   2131 C C   . TYR A 1 273 ? 16.07792  -15.23850 17.61337  1.000 7.70550  ? 284 TYR A C   1 
ATOM   2132 O O   . TYR A 1 273 ? 17.19335  -15.77017 17.58934  1.000 7.55589  ? 284 TYR A O   1 
ATOM   2133 C CB  . TYR A 1 273 ? 15.06931  -14.40159 19.76891  1.000 7.42848  ? 284 TYR A CB  1 
ATOM   2134 C CG  . TYR A 1 273 ? 16.43362  -13.84412 20.14307  1.000 6.55218  ? 284 TYR A CG  1 
ATOM   2135 C CD1 . TYR A 1 273 ? 17.00988  -12.80354 19.41055  1.000 8.81619  ? 284 TYR A CD1 1 
ATOM   2136 C CD2 . TYR A 1 273 ? 17.14722  -14.36622 21.23315  1.000 7.80781  ? 284 TYR A CD2 1 
ATOM   2137 C CE1 . TYR A 1 273 ? 18.25903  -12.29518 19.74436  1.000 9.72204  ? 284 TYR A CE1 1 
ATOM   2138 C CE2 . TYR A 1 273 ? 18.39282  -13.86402 21.57815  1.000 9.87937  ? 284 TYR A CE2 1 
ATOM   2139 C CZ  . TYR A 1 273 ? 18.94047  -12.83143 20.83291  1.000 14.70031 ? 284 TYR A CZ  1 
ATOM   2140 O OH  . TYR A 1 273 ? 20.17628  -12.31921 21.16115  1.000 16.79468 ? 284 TYR A OH  1 
ATOM   2141 N N   . LYS A 1 274 ? 15.66142  -14.35331 16.71056  1.000 5.80187  ? 285 LYS A N   1 
ATOM   2142 C CA  . LYS A 1 274 ? 16.51619  -13.87569 15.62899  1.000 7.36239  ? 285 LYS A CA  1 
ATOM   2143 C C   . LYS A 1 274 ? 16.28727  -12.37995 15.44522  1.000 7.73167  ? 285 LYS A C   1 
ATOM   2144 O O   . LYS A 1 274 ? 15.15172  -11.91621 15.52438  1.000 8.39837  ? 285 LYS A O   1 
ATOM   2145 C CB  . LYS A 1 274 ? 16.23038  -14.63505 14.31544  1.000 7.18959  ? 285 LYS A CB  1 
ATOM   2146 C CG  . LYS A 1 274 ? 17.11192  -14.19932 13.13780  1.000 10.52406 ? 285 LYS A CG  1 
ATOM   2147 C CD  . LYS A 1 274 ? 17.05579  -15.22687 12.00174  1.000 10.34056 ? 285 LYS A CD  1 
ATOM   2148 C CE  . LYS A 1 274 ? 17.76531  -14.71276 10.74263  1.000 18.08896 ? 285 LYS A CE  1 
ATOM   2149 N NZ  . LYS A 1 274 ? 19.22579  -14.53044 10.94775  1.000 16.41327 ? 285 LYS A NZ  1 
ATOM   2150 N N   . THR A 1 275 ? 17.37021  -11.63428 15.19306  1.000 6.54086  ? 286 THR A N   1 
ATOM   2151 C CA  . THR A 1 275 ? 17.26029  -10.20184 14.91425  1.000 9.08566  ? 286 THR A CA  1 
ATOM   2152 C C   . THR A 1 275 ? 16.81434  -9.97150  13.47280  1.000 8.90695  ? 286 THR A C   1 
ATOM   2153 O O   . THR A 1 275 ? 17.39786  -10.52882 12.53874  1.000 10.54972 ? 286 THR A O   1 
ATOM   2154 C CB  . THR A 1 275 ? 18.60760  -9.51706  15.15016  1.000 8.55599  ? 286 THR A CB  1 
ATOM   2155 O OG1 . THR A 1 275 ? 19.04439  -9.77543  16.48770  1.000 11.98799 ? 286 THR A OG1 1 
ATOM   2156 C CG2 . THR A 1 275 ? 18.47971  -8.00655  14.96454  1.000 11.52194 ? 286 THR A CG2 1 
ATOM   2157 N N   . LEU A 1 276 ? 15.77890  -9.15427  13.29659  1.000 7.91641  ? 287 LEU A N   1 
ATOM   2158 C CA  . LEU A 1 276 ? 15.21595  -8.83192  11.98905  1.000 8.49282  ? 287 LEU A CA  1 
ATOM   2159 C C   . LEU A 1 276 ? 15.94591  -7.65391  11.34082  1.000 9.70007  ? 287 LEU A C   1 
ATOM   2160 O O   . LEU A 1 276 ? 16.77285  -6.97853  11.95559  1.000 8.85427  ? 287 LEU A O   1 
ATOM   2161 C CB  . LEU A 1 276 ? 13.71816  -8.52352  12.09700  1.000 7.94688  ? 287 LEU A CB  1 
ATOM   2162 C CG  . LEU A 1 276 ? 12.87096  -9.62731  12.73852  1.000 7.46449  ? 287 LEU A CG  1 
ATOM   2163 C CD1 . LEU A 1 276 ? 11.41855  -9.23621  12.68212  1.000 8.68963  ? 287 LEU A CD1 1 
ATOM   2164 C CD2 . LEU A 1 276 ? 13.08454  -10.95092 12.00317  1.000 8.17926  ? 287 LEU A CD2 1 
ATOM   2165 N N   . GLU A 1 277 ? 15.59095  -7.40827  10.07603  1.000 11.01290 ? 288 GLU A N   1 
ATOM   2166 C CA  . GLU A 1 277 ? 16.21724  -6.33895  9.29823   1.000 10.99927 ? 288 GLU A CA  1 
ATOM   2167 C C   . GLU A 1 277 ? 16.09954  -4.97640  9.98148   1.000 14.39416 ? 288 GLU A C   1 
ATOM   2168 O O   . GLU A 1 277 ? 17.01480  -4.14553  9.88416   1.000 11.23884 ? 288 GLU A O   1 
ATOM   2169 C CB  . GLU A 1 277 ? 15.58120  -6.30448  7.90972   1.000 10.98668 ? 288 GLU A CB  1 
ATOM   2170 C CG  . GLU A 1 277 ? 16.08622  -5.19866  7.01038   1.000 12.59066 ? 288 GLU A CG  1 
ATOM   2171 C CD  . GLU A 1 277 ? 17.49375  -5.45812  6.51723   1.000 25.00989 ? 288 GLU A CD  1 
ATOM   2172 O OE1 . GLU A 1 277 ? 17.93646  -6.63099  6.55400   1.000 22.89716 ? 288 GLU A OE1 1 
ATOM   2173 O OE2 . GLU A 1 277 ? 18.16350  -4.48348  6.11336   1.000 28.09216 ? 288 GLU A OE2 1 
ATOM   2174 N N   . ASN A 1 278 ? 14.98323  -4.72127  10.66873  1.000 10.09621 ? 289 ASN A N   1 
ATOM   2175 C CA  . ASN A 1 278 ? 14.73400  -3.44258  11.33337  1.000 6.48387  ? 289 ASN A CA  1 
ATOM   2176 C C   . ASN A 1 278 ? 15.25583  -3.38520  12.76684  1.000 10.08835 ? 289 ASN A C   1 
ATOM   2177 O O   . ASN A 1 278 ? 15.01054  -2.39361  13.46951  1.000 10.98753 ? 289 ASN A O   1 
ATOM   2178 C CB  . ASN A 1 278 ? 13.23768  -3.12278  11.30596  1.000 6.49325  ? 289 ASN A CB  1 
ATOM   2179 C CG  . ASN A 1 278 ? 12.41804  -4.06367  12.17235  1.000 7.15607  ? 289 ASN A CG  1 
ATOM   2180 O OD1 . ASN A 1 278 ? 12.88885  -5.12645  12.57293  1.000 8.38794  ? 289 ASN A OD1 1 
ATOM   2181 N ND2 . ASN A 1 278 ? 11.16544  -3.68599  12.43379  1.000 7.25015  ? 289 ASN A ND2 1 
ATOM   2182 N N   . GLY A 1 279 ? 15.95977  -4.42581  13.22475  1.000 9.15958  ? 290 GLY A N   1 
ATOM   2183 C CA  . GLY A 1 279 ? 16.51161  -4.47818  14.55905  1.000 8.83959  ? 290 GLY A CA  1 
ATOM   2184 C C   . GLY A 1 279 ? 15.60414  -5.06318  15.61414  1.000 7.79076  ? 290 GLY A C   1 
ATOM   2185 O O   . GLY A 1 279 ? 16.05580  -5.25919  16.74473  1.000 11.45504 ? 290 GLY A O   1 
ATOM   2186 N N   . MET A 1 280 ? 14.33130  -5.29251  15.30566  1.000 7.23213  ? 291 MET A N   1 
ATOM   2187 C CA  . MET A 1 280 ? 13.44449  -5.99519  16.22973  1.000 6.44643  ? 291 MET A CA  1 
ATOM   2188 C C   . MET A 1 280 ? 13.94505  -7.42398  16.40297  1.000 7.47512  ? 291 MET A C   1 
ATOM   2189 O O   . MET A 1 280 ? 14.67672  -7.96429  15.55555  1.000 8.94577  ? 291 MET A O   1 
ATOM   2190 C CB  . MET A 1 280 ? 12.05664  -6.02945  15.59554  1.000 7.63063  ? 291 MET A CB  1 
ATOM   2191 C CG  . MET A 1 280 ? 11.32253  -4.69270  15.61840  1.000 8.52508  ? 291 MET A CG  1 
ATOM   2192 S SD  . MET A 1 280 ? 9.59654   -4.93740  15.21662  1.000 9.99064  ? 291 MET A SD  1 
ATOM   2193 C CE  . MET A 1 280 ? 9.03082   -3.23798  15.24334  1.000 9.81293  ? 291 MET A CE  1 
ATOM   2194 N N   . LYS A 1 281 ? 13.55943  -8.03555  17.51420  1.000 6.32473  ? 292 LYS A N   1 
ATOM   2195 C CA  . LYS A 1 281 ? 13.78419  -9.46297  17.71844  1.000 6.22700  ? 292 LYS A CA  1 
ATOM   2196 C C   . LYS A 1 281 ? 12.48626  -10.22714 17.48971  1.000 6.88275  ? 292 LYS A C   1 
ATOM   2197 O O   . LYS A 1 281 ? 11.45253  -9.88932  18.07874  1.000 10.26428 ? 292 LYS A O   1 
ATOM   2198 C CB  . LYS A 1 281 ? 14.29511  -9.74597  19.13259  1.000 10.15320 ? 292 LYS A CB  1 
ATOM   2199 C CG  . LYS A 1 281 ? 15.37405  -8.77613  19.62482  1.000 10.73216 ? 292 LYS A CG  1 
ATOM   2200 C CD  . LYS A 1 281 ? 16.65198  -8.84541  18.80273  1.000 13.76894 ? 292 LYS A CD  1 
ATOM   2201 C CE  . LYS A 1 281 ? 17.71262  -7.95933  19.44341  1.000 16.39831 ? 292 LYS A CE  1 
ATOM   2202 N NZ  . LYS A 1 281 ? 18.98710  -7.91704  18.66126  1.000 17.83976 ? 292 LYS A NZ  1 
ATOM   2203 N N   . PHE A 1 282 ? 12.53616  -11.23600 16.62687  1.000 5.85110  ? 293 PHE A N   1 
ATOM   2204 C CA  . PHE A 1 282 ? 11.43359  -12.17991 16.49875  1.000 4.98214  ? 293 PHE A CA  1 
ATOM   2205 C C   . PHE A 1 282 ? 11.69681  -13.34783 17.43984  1.000 6.41982  ? 293 PHE A C   1 
ATOM   2206 O O   . PHE A 1 282 ? 12.77094  -13.96137 17.39305  1.000 7.32441  ? 293 PHE A O   1 
ATOM   2207 C CB  . PHE A 1 282 ? 11.29129  -12.69421 15.05573  1.000 7.41485  ? 293 PHE A CB  1 
ATOM   2208 C CG  . PHE A 1 282 ? 10.34700  -13.86266 14.94298  1.000 6.37624  ? 293 PHE A CG  1 
ATOM   2209 C CD1 . PHE A 1 282 ? 8.99519   -13.69754 15.18722  1.000 8.50059  ? 293 PHE A CD1 1 
ATOM   2210 C CD2 . PHE A 1 282 ? 10.81732  -15.13303 14.65453  1.000 9.74689  ? 293 PHE A CD2 1 
ATOM   2211 C CE1 . PHE A 1 282 ? 8.12561   -14.76293 15.13052  1.000 9.52837  ? 293 PHE A CE1 1 
ATOM   2212 C CE2 . PHE A 1 282 ? 9.95768   -16.20423 14.60453  1.000 9.55677  ? 293 PHE A CE2 1 
ATOM   2213 C CZ  . PHE A 1 282 ? 8.60269   -16.02119 14.82853  1.000 8.87154  ? 293 PHE A CZ  1 
ATOM   2214 N N   . VAL A 1 283 ? 10.72719  -13.64003 18.31026  1.000 6.16170  ? 294 VAL A N   1 
ATOM   2215 C CA  . VAL A 1 283 ? 10.85192  -14.69435 19.31515  1.000 5.91263  ? 294 VAL A CA  1 
ATOM   2216 C C   . VAL A 1 283 ? 9.83276   -15.77624 19.01140  1.000 5.37424  ? 294 VAL A C   1 
ATOM   2217 O O   . VAL A 1 283 ? 8.63775   -15.48899 18.87442  1.000 8.37174  ? 294 VAL A O   1 
ATOM   2218 C CB  . VAL A 1 283 ? 10.64791  -14.16282 20.74442  1.000 6.19901  ? 294 VAL A CB  1 
ATOM   2219 C CG1 . VAL A 1 283 ? 10.78597  -15.30572 21.73996  1.000 7.30555  ? 294 VAL A CG1 1 
ATOM   2220 C CG2 . VAL A 1 283 ? 11.64726  -13.07178 21.06054  1.000 6.69988  ? 294 VAL A CG2 1 
ATOM   2221 N N   . LEU A 1 284 ? 10.29701  -17.01658 18.91332  1.000 6.87165  ? 295 LEU A N   1 
ATOM   2222 C CA  . LEU A 1 284 ? 9.43484   -18.18008 18.75123  1.000 4.65997  ? 295 LEU A CA  1 
ATOM   2223 C C   . LEU A 1 284 ? 9.50816   -18.98462 20.04018  1.000 6.03726  ? 295 LEU A C   1 
ATOM   2224 O O   . LEU A 1 284 ? 10.59891  -19.34223 20.47181  1.000 6.83398  ? 295 LEU A O   1 
ATOM   2225 C CB  . LEU A 1 284 ? 9.87800   -19.02723 17.54775  1.000 6.07242  ? 295 LEU A CB  1 
ATOM   2226 C CG  . LEU A 1 284 ? 9.07783   -20.29292 17.25077  1.000 6.91416  ? 295 LEU A CG  1 
ATOM   2227 C CD1 . LEU A 1 284 ? 7.65507   -19.95426 16.84529  1.000 11.57999 ? 295 LEU A CD1 1 
ATOM   2228 C CD2 . LEU A 1 284 ? 9.78095   -21.08841 16.13988  1.000 8.95326  ? 295 LEU A CD2 1 
ATOM   2229 N N   . THR A 1 285 ? 8.35690   -19.27636 20.64576  1.000 6.31626  ? 296 THR A N   1 
ATOM   2230 C CA  . THR A 1 285 ? 8.35783   -19.92111 21.95509  1.000 6.35256  ? 296 THR A CA  1 
ATOM   2231 C C   . THR A 1 285 ? 7.33143   -21.05011 22.03593  1.000 7.73802  ? 296 THR A C   1 
ATOM   2232 O O   . THR A 1 285 ? 6.29312   -21.02678 21.36956  1.000 8.58713  ? 296 THR A O   1 
ATOM   2233 C CB  . THR A 1 285 ? 8.11604   -18.88328 23.05452  1.000 8.47392  ? 296 THR A CB  1 
ATOM   2234 O OG1 . THR A 1 285 ? 8.26208   -19.53441 24.32037  1.000 10.31594 ? 296 THR A OG1 1 
ATOM   2235 C CG2 . THR A 1 285 ? 6.72530   -18.29429 22.94793  1.000 10.49521 ? 296 THR A CG2 1 
ATOM   2236 N N   . ALA A 1 286 ? 7.61904   -22.04081 22.88565  1.000 6.45138  ? 297 ALA A N   1 
ATOM   2237 C CA  . ALA A 1 286 ? 6.72136   -23.17161 23.09654  1.000 7.77030  ? 297 ALA A CA  1 
ATOM   2238 C C   . ALA A 1 286 ? 6.93139   -23.71811 24.49643  1.000 6.67468  ? 297 ALA A C   1 
ATOM   2239 O O   . ALA A 1 286 ? 8.01906   -23.56340 25.06364  1.000 8.21944  ? 297 ALA A O   1 
ATOM   2240 C CB  . ALA A 1 286 ? 6.95883   -24.29208 22.07228  1.000 7.34157  ? 297 ALA A CB  1 
ATOM   2241 N N   . PRO A 1 287 ? 5.92649   -24.37752 25.07482  1.000 6.29237  ? 298 PRO A N   1 
ATOM   2242 C CA  . PRO A 1 287 ? 6.15119   -25.06630 26.34680  1.000 7.66181  ? 298 PRO A CA  1 
ATOM   2243 C C   . PRO A 1 287 ? 7.16035   -26.18622 26.16247  1.000 7.31749  ? 298 PRO A C   1 
ATOM   2244 O O   . PRO A 1 287 ? 7.15335   -26.89236 25.14972  1.000 7.19002  ? 298 PRO A O   1 
ATOM   2245 C CB  . PRO A 1 287 ? 4.75612   -25.60020 26.72098  1.000 8.13082  ? 298 PRO A CB  1 
ATOM   2246 C CG  . PRO A 1 287 ? 3.79548   -24.81705 25.87600  1.000 11.34074 ? 298 PRO A CG  1 
ATOM   2247 C CD  . PRO A 1 287 ? 4.53722   -24.51962 24.60115  1.000 8.21160  ? 298 PRO A CD  1 
ATOM   2248 N N   . LYS A 1 288 ? 8.03253   -26.34752 27.16526  1.000 6.58657  ? 299 LYS A N   1 
ATOM   2249 C CA  . LYS A 1 288 ? 9.04301   -27.40048 27.12763  1.000 8.05419  ? 299 LYS A CA  1 
ATOM   2250 C C   . LYS A 1 288 ? 8.42272   -28.77523 26.88993  1.000 9.38922  ? 299 LYS A C   1 
ATOM   2251 O O   . LYS A 1 288 ? 8.97456   -29.58610 26.14311  1.000 9.02185  ? 299 LYS A O   1 
ATOM   2252 C CB  . LYS A 1 288 ? 9.84541   -27.36346 28.43095  1.000 12.45145 ? 299 LYS A CB  1 
ATOM   2253 C CG  . LYS A 1 288 ? 10.63842  -28.62614 28.76333  1.000 18.86194 ? 299 LYS A CG  1 
ATOM   2254 C CD  . LYS A 1 288 ? 11.03878  -28.67382 30.24660  1.000 22.42143 ? 299 LYS A CD  1 
ATOM   2255 C CE  . LYS A 1 288 ? 9.85329   -29.02953 31.15940  1.000 23.42855 ? 299 LYS A CE  1 
ATOM   2256 N NZ  . LYS A 1 288 ? 10.21275  -29.02961 32.61821  1.000 28.76739 ? 299 LYS A NZ  1 
ATOM   2257 N N   . THR A 1 289 ? 7.25584   -29.04219 27.49041  1.000 8.45111  ? 300 THR A N   1 
ATOM   2258 C CA  . THR A 1 289 ? 6.62196   -30.34764 27.30631  1.000 9.71741  ? 300 THR A CA  1 
ATOM   2259 C C   . THR A 1 289 ? 6.28839   -30.64855 25.85017  1.000 9.25889  ? 300 THR A C   1 
ATOM   2260 O O   . THR A 1 289 ? 6.23758   -31.82443 25.47724  1.000 11.01089 ? 300 THR A O   1 
ATOM   2261 C CB  . THR A 1 289 ? 5.35934   -30.47636 28.16351  1.000 10.98207 ? 300 THR A CB  1 
ATOM   2262 O OG1 . THR A 1 289 ? 4.40126   -29.47628 27.79198  1.000 12.60499 ? 300 THR A OG1 1 
ATOM   2263 C CG2 . THR A 1 289 ? 5.69775   -30.36963 29.64746  1.000 13.83427 ? 300 THR A CG2 1 
ATOM   2264 N N   . GLU A 1 290 ? 6.09562   -29.62581 25.00849  1.000 9.12502  ? 301 GLU A N   1 
ATOM   2265 C CA  . GLU A 1 290 ? 5.78895   -29.88311 23.60566  1.000 9.84537  ? 301 GLU A CA  1 
ATOM   2266 C C   . GLU A 1 290 ? 7.01192   -30.31107 22.80402  1.000 11.59738 ? 301 GLU A C   1 
ATOM   2267 O O   . GLU A 1 290 ? 6.86212   -30.98837 21.78055  1.000 13.62554 ? 301 GLU A O   1 
ATOM   2268 C CB  . GLU A 1 290 ? 5.07704   -28.66614 22.99340  1.000 10.79159 ? 301 GLU A CB  1 
ATOM   2269 C CG  . GLU A 1 290 ? 3.76745   -28.39070 23.70996  1.000 12.79478 ? 301 GLU A CG  1 
ATOM   2270 C CD  . GLU A 1 290 ? 2.87521   -27.36356 23.04163  1.000 14.89604 ? 301 GLU A CD  1 
ATOM   2271 O OE1 . GLU A 1 290 ? 3.21411   -26.88685 21.93388  1.000 13.89661 ? 301 GLU A OE1 1 
ATOM   2272 O OE2 . GLU A 1 290 ? 1.83703   -27.02627 23.65372  1.000 18.43613 ? 301 GLU A OE2 1 
ATOM   2273 N N   . LEU A 1 291 ? 8.22141   -29.96371 23.25750  1.000 10.86681 ? 302 LEU A N   1 
ATOM   2274 C CA  . LEU A 1 291 ? 9.43370   -30.49290 22.64288  1.000 9.74842  ? 302 LEU A CA  1 
ATOM   2275 C C   . LEU A 1 291 ? 9.75939   -31.89739 23.12208  1.000 13.97663 ? 302 LEU A C   1 
ATOM   2276 O O   . LEU A 1 291 ? 10.47183  -32.62980 22.42881  1.000 13.89824 ? 302 LEU A O   1 
ATOM   2277 C CB  . LEU A 1 291 ? 10.61667  -29.58301 22.97841  1.000 9.50626  ? 302 LEU A CB  1 
ATOM   2278 C CG  . LEU A 1 291 ? 10.71885  -28.26023 22.21192  1.000 10.20502 ? 302 LEU A CG  1 
ATOM   2279 C CD1 . LEU A 1 291 ? 9.77418   -27.21844 22.80565  1.000 11.99868 ? 302 LEU A CD1 1 
ATOM   2280 C CD2 . LEU A 1 291 ? 12.17946  -27.78330 22.24300  1.000 11.58089 ? 302 LEU A CD2 1 
ATOM   2281 N N   . GLN A 1 292 ? 9.26973   -32.27403 24.29870  1.000 12.85426 ? 303 GLN A N   1 
ATOM   2282 C CA  . GLN A 1 292 ? 9.60524   -33.55842 24.88708  1.000 16.31678 ? 303 GLN A CA  1 
ATOM   2283 C C   . GLN A 1 292 ? 8.91752   -34.69123 24.13940  1.000 29.00236 ? 303 GLN A C   1 
ATOM   2284 O O   . GLN A 1 292 ? 7.85290   -34.51779 23.54069  1.000 30.17550 ? 303 GLN A O   1 
ATOM   2285 C CB  . GLN A 1 292 ? 9.23542   -33.55495 26.37752  1.000 10.56759 ? 303 GLN A CB  1 
ATOM   2286 C CG  . GLN A 1 292 ? 10.25256  -32.76569 27.20061  1.000 12.23711 ? 303 GLN A CG  1 
ATOM   2287 C CD  . GLN A 1 292 ? 9.85911   -32.56612 28.65679  1.000 13.24200 ? 303 GLN A CD  1 
ATOM   2288 O OE1 . GLN A 1 292 ? 8.68779   -32.40572 28.97893  1.000 18.88640 ? 303 GLN A OE1 1 
ATOM   2289 N NE2 . GLN A 1 292 ? 10.85138  -32.57215 29.54252  1.000 18.04197 ? 303 GLN A NE2 1 
ATOM   2290 N N   . GLU A 1 293 ? 9.55335   -35.85668 24.17212  1.000 29.05903 ? 304 GLU A N   1 
ATOM   2291 C CA  . GLU A 1 293 ? 9.13272   -37.00946 23.38372  1.000 38.90888 ? 304 GLU A CA  1 
ATOM   2292 C C   . GLU A 1 293 ? 8.16341   -37.89548 24.15971  1.000 34.63298 ? 304 GLU A C   1 
ATOM   2293 O O   . GLU A 1 293 ? 7.13780   -38.31981 23.62547  1.000 44.11299 ? 304 GLU A O   1 
ATOM   2294 C CB  . GLU A 1 293 ? 10.36094  -37.81641 22.95258  1.000 34.44529 ? 304 GLU A CB  1 
ATOM   2295 C CG  . GLU A 1 293 ? 10.04971  -39.19112 22.38165  1.000 50.03135 ? 304 GLU A CG  1 
ATOM   2296 C CD  . GLU A 1 293 ? 11.27155  -40.09312 22.34006  1.000 64.09885 ? 304 GLU A CD  1 
ATOM   2297 O OE1 . GLU A 1 293 ? 12.37451  -39.62189 22.69879  1.000 57.15274 ? 304 GLU A OE1 1 
ATOM   2298 O OE2 . GLU A 1 293 ? 11.12905  -41.27124 21.94464  1.000 60.51973 ? 304 GLU A OE2 1 
HETATM 2299 N N1  . URA B 2 .   ? 5.05083   11.22869  6.66893   1.000 6.37265  ? 401 URA A N1  1 
HETATM 2300 C C2  . URA B 2 .   ? 3.90240   11.95523  6.78015   1.000 6.40476  ? 401 URA A C2  1 
HETATM 2301 O O2  . URA B 2 .   ? 2.95388   11.59300  7.46581   1.000 6.81553  ? 401 URA A O2  1 
HETATM 2302 N N3  . URA B 2 .   ? 3.89174   13.14854  6.10435   1.000 7.91479  ? 401 URA A N3  1 
HETATM 2303 C C4  . URA B 2 .   ? 4.91141   13.63321  5.30218   1.000 7.35972  ? 401 URA A C4  1 
HETATM 2304 O O4  . URA B 2 .   ? 4.77689   14.73394  4.73410   1.000 6.63240  ? 401 URA A O4  1 
HETATM 2305 C C5  . URA B 2 .   ? 6.07928   12.79553  5.22792   1.000 6.41891  ? 401 URA A C5  1 
HETATM 2306 C C6  . URA B 2 .   ? 6.10041   11.62612  5.90530   1.000 5.92939  ? 401 URA A C6  1 
HETATM 2307 C C   . ACT C 3 .   ? 5.93984   -15.70206 26.28906  1.000 11.28026 ? 402 ACT A C   1 
HETATM 2308 O O   . ACT C 3 .   ? 4.88619   -15.28225 25.69230  1.000 11.16177 ? 402 ACT A O   1 
HETATM 2309 O OXT . ACT C 3 .   ? 6.33130   -16.89406 26.43933  1.000 11.25510 ? 402 ACT A OXT 1 
HETATM 2310 C CH3 . ACT C 3 .   ? 6.85986   -14.61888 26.88860  1.000 10.19706 ? 402 ACT A CH3 1 
HETATM 2311 C C1  . EDO D 4 .   ? 8.06693   5.11877   18.49501  1.000 24.59232 ? 403 EDO A C1  1 
HETATM 2312 O O1  . EDO D 4 .   ? 9.32428   4.93656   19.16545  1.000 23.75085 ? 403 EDO A O1  1 
HETATM 2313 C C2  . EDO D 4 .   ? 8.28416   5.94378   17.23531  1.000 17.89438 ? 403 EDO A C2  1 
HETATM 2314 O O2  . EDO D 4 .   ? 9.16485   5.26303   16.33774  1.000 14.92630 ? 403 EDO A O2  1 
HETATM 2315 O O   . HOH E 5 .   ? 16.31097  9.79593   17.60452  1.000 22.78011 ? 501 HOH A O   1 
HETATM 2316 O O   . HOH E 5 .   ? 20.46047  4.31230   -7.17622  1.000 22.84748 ? 502 HOH A O   1 
HETATM 2317 O O   . HOH E 5 .   ? 16.15064  -26.67107 25.37751  1.000 26.43023 ? 503 HOH A O   1 
HETATM 2318 O O   . HOH E 5 .   ? 24.34371  5.83104   -1.63934  1.000 40.92204 ? 504 HOH A O   1 
HETATM 2319 O O   . HOH E 5 .   ? -0.05114  -22.35238 12.13862  1.000 36.19903 ? 505 HOH A O   1 
HETATM 2320 O O   . HOH E 5 .   ? 17.11119  -11.09336 9.82543   1.000 29.42068 ? 506 HOH A O   1 
HETATM 2321 O O   . HOH E 5 .   ? 24.23775  -17.70702 18.02220  1.000 35.29227 ? 507 HOH A O   1 
HETATM 2322 O O   . HOH E 5 .   ? 26.34183  21.56931  3.56420   1.000 37.73452 ? 508 HOH A O   1 
HETATM 2323 O O   . HOH E 5 .   ? 26.093    17.468    -2.399    1.000 29.19673 ? 509 HOH A O   1 
HETATM 2324 O O   . HOH E 5 .   ? 9.27010   20.17775  21.77105  1.000 35.50484 ? 510 HOH A O   1 
HETATM 2325 O O   . HOH E 5 .   ? 19.24670  -25.72733 18.62656  1.000 24.69912 ? 511 HOH A O   1 
HETATM 2326 O O   . HOH E 5 .   ? 15.46215  11.68262  19.39907  1.000 25.40036 ? 512 HOH A O   1 
HETATM 2327 O O   . HOH E 5 .   ? -1.55981  -0.98342  11.24973  1.000 23.78122 ? 513 HOH A O   1 
HETATM 2328 O O   . HOH E 5 .   ? 2.44922   -30.55383 26.57625  1.000 25.51241 ? 514 HOH A O   1 
HETATM 2329 O O   . HOH E 5 .   ? 5.90723   -2.39209  31.26404  1.000 19.52772 ? 515 HOH A O   1 
HETATM 2330 O O   . HOH E 5 .   ? -3.04956  -13.87224 9.93761   1.000 28.24441 ? 516 HOH A O   1 
HETATM 2331 O O   . HOH E 5 .   ? 22.37668  3.93993   -0.64667  1.000 25.00469 ? 517 HOH A O   1 
HETATM 2332 O O   . HOH E 5 .   ? 2.06736   26.80433  6.04130   1.000 35.28402 ? 518 HOH A O   1 
HETATM 2333 O O   . HOH E 5 .   ? 9.63693   24.87145  -1.92783  1.000 21.19518 ? 519 HOH A O   1 
HETATM 2334 O O   . HOH E 5 .   ? -1.52486  16.57405  9.12734   1.000 27.53523 ? 520 HOH A O   1 
HETATM 2335 O O   . HOH E 5 .   ? 21.99086  -9.11693  27.99285  1.000 32.36690 ? 521 HOH A O   1 
HETATM 2336 O O   . HOH E 5 .   ? 17.09319  -24.31533 26.47326  1.000 21.71679 ? 522 HOH A O   1 
HETATM 2337 O O   . HOH E 5 .   ? 4.92543   25.50224  2.47970   1.000 27.85049 ? 523 HOH A O   1 
HETATM 2338 O O   . HOH E 5 .   ? 15.63501  -3.75019  29.43348  1.000 29.34983 ? 524 HOH A O   1 
HETATM 2339 O O   . HOH E 5 .   ? 14.45352  0.84726   15.56863  1.000 23.07814 ? 525 HOH A O   1 
HETATM 2340 O O   . HOH E 5 .   ? 17.75392  -1.96911  6.70068   1.000 18.18815 ? 526 HOH A O   1 
HETATM 2341 O O   . HOH E 5 .   ? 26.04520  9.03380   1.50622   1.000 25.97653 ? 527 HOH A O   1 
HETATM 2342 O O   . HOH E 5 .   ? 1.13328   27.15389  10.46699  1.000 32.93312 ? 528 HOH A O   1 
HETATM 2343 O O   . HOH E 5 .   ? 12.33839  -17.69696 33.95685  1.000 13.32315 ? 529 HOH A O   1 
HETATM 2344 O O   . HOH E 5 .   ? 16.16952  -13.18849 4.45963   1.000 23.85487 ? 530 HOH A O   1 
HETATM 2345 O O   . HOH E 5 .   ? 18.57066  -5.29513  17.56699  1.000 20.63317 ? 531 HOH A O   1 
HETATM 2346 O O   . HOH E 5 .   ? 15.02879  29.94922  3.16187   1.000 29.05362 ? 532 HOH A O   1 
HETATM 2347 O O   . HOH E 5 .   ? 8.02316   0.02456   28.27456  1.000 22.53578 ? 533 HOH A O   1 
HETATM 2348 O O   . HOH E 5 .   ? 8.87072   2.55199   20.54168  1.000 15.30647 ? 534 HOH A O   1 
HETATM 2349 O O   . HOH E 5 .   ? 1.10212   -9.87355  5.99742   1.000 26.47955 ? 535 HOH A O   1 
HETATM 2350 O O   . HOH E 5 .   ? -2.72306  -8.92053  13.15581  1.000 24.06509 ? 536 HOH A O   1 
HETATM 2351 O O   . HOH E 5 .   ? 1.66948   -25.90049 14.74129  1.000 30.10556 ? 537 HOH A O   1 
HETATM 2352 O O   . HOH E 5 .   ? 2.53909   2.34497   20.28461  1.000 29.51829 ? 538 HOH A O   1 
HETATM 2353 O O   . HOH E 5 .   ? 5.36288   8.72440   7.87016   1.000 8.56029  ? 539 HOH A O   1 
HETATM 2354 O O   . HOH E 5 .   ? 8.10062   22.27864  -5.10741  1.000 29.16814 ? 540 HOH A O   1 
HETATM 2355 O O   . HOH E 5 .   ? 13.775    13.335    -13.205   1.000 20.36871 ? 541 HOH A O   1 
HETATM 2356 O O   . HOH E 5 .   ? 3.15209   -24.95430 37.39687  1.000 23.16637 ? 542 HOH A O   1 
HETATM 2357 O O   . HOH E 5 .   ? 27.95507  -11.19383 23.96208  1.000 41.44174 ? 543 HOH A O   1 
HETATM 2358 O O   . HOH E 5 .   ? 8.29483   -21.62627 8.50304   1.000 26.37980 ? 544 HOH A O   1 
HETATM 2359 O O   . HOH E 5 .   ? -0.28536  21.28662  -2.57527  1.000 28.91948 ? 545 HOH A O   1 
HETATM 2360 O O   . HOH E 5 .   ? 23.209    29.881    0.138     1.000 31.89717 ? 546 HOH A O   1 
HETATM 2361 O O   . HOH E 5 .   ? -0.54509  24.22149  5.31124   1.000 28.25723 ? 547 HOH A O   1 
HETATM 2362 O O   . HOH E 5 .   ? 25.59527  -8.83044  22.53991  1.000 30.98086 ? 548 HOH A O   1 
HETATM 2363 O O   . HOH E 5 .   ? 16.48510  19.59896  11.89688  1.000 16.23902 ? 549 HOH A O   1 
HETATM 2364 O O   . HOH E 5 .   ? 3.88623   -25.52368 3.82305   1.000 32.17407 ? 550 HOH A O   1 
HETATM 2365 O O   . HOH E 5 .   ? -1.33018  17.19448  3.83263   1.000 21.64328 ? 551 HOH A O   1 
HETATM 2366 O O   . HOH E 5 .   ? 18.666    30.509    -7.717    1.000 15.67949 ? 552 HOH A O   1 
HETATM 2367 O O   . HOH E 5 .   ? 7.711     -36.456   0.828     1.000 23.97193 ? 553 HOH A O   1 
HETATM 2368 O O   . HOH E 5 .   ? 2.10622   -1.51249  4.00296   1.000 15.37414 ? 554 HOH A O   1 
HETATM 2369 O O   . HOH E 5 .   ? 15.11081  28.03106  0.57187   1.000 26.87217 ? 555 HOH A O   1 
HETATM 2370 O O   . HOH E 5 .   ? 3.83085   15.50464  -2.87936  1.000 9.19547  ? 556 HOH A O   1 
HETATM 2371 O O   . HOH E 5 .   ? 13.72961  -5.35215  -3.40682  1.000 33.32743 ? 557 HOH A O   1 
HETATM 2372 O O   . HOH E 5 .   ? 16.14622  -1.35379  22.40349  1.000 26.91217 ? 558 HOH A O   1 
HETATM 2373 O O   . HOH E 5 .   ? 17.74581  -17.52386 20.77519  1.000 8.51269  ? 559 HOH A O   1 
HETATM 2374 O O   . HOH E 5 .   ? 20.48941  -20.83335 12.98875  1.000 12.62332 ? 560 HOH A O   1 
HETATM 2375 O O   . HOH E 5 .   ? 19.13010  -30.21075 19.25241  1.000 33.72638 ? 561 HOH A O   1 
HETATM 2376 O O   . HOH E 5 .   ? 1.12256   -15.68488 26.69674  1.000 25.96792 ? 562 HOH A O   1 
HETATM 2377 O O   . HOH E 5 .   ? 31.14998  22.38384  2.69862   1.000 34.86208 ? 563 HOH A O   1 
HETATM 2378 O O   . HOH E 5 .   ? -3.32964  10.70466  1.15621   1.000 20.31924 ? 564 HOH A O   1 
HETATM 2379 O O   . HOH E 5 .   ? 18.12071  -6.78462  26.87030  1.000 20.86429 ? 565 HOH A O   1 
HETATM 2380 O O   . HOH E 5 .   ? 7.29713   20.51106  13.23203  1.000 12.44620 ? 566 HOH A O   1 
HETATM 2381 O O   . HOH E 5 .   ? 26.909    19.612    11.617    1.000 13.95139 ? 567 HOH A O   1 
HETATM 2382 O O   . HOH E 5 .   ? 9.58878   25.91769  7.53680   1.000 17.79091 ? 568 HOH A O   1 
HETATM 2383 O O   . HOH E 5 .   ? 20.772    14.655    -13.295   1.000 24.01320 ? 569 HOH A O   1 
HETATM 2384 O O   . HOH E 5 .   ? 12.01934  0.55564   -9.29039  1.000 36.04973 ? 570 HOH A O   1 
HETATM 2385 O O   . HOH E 5 .   ? 12.34297  -12.66572 2.42135   1.000 29.61828 ? 571 HOH A O   1 
HETATM 2386 O O   . HOH E 5 .   ? 4.59168   -6.87608  29.35323  1.000 15.59263 ? 572 HOH A O   1 
HETATM 2387 O O   . HOH E 5 .   ? 14.01901  29.90861  10.15457  1.000 20.13999 ? 573 HOH A O   1 
HETATM 2388 O O   . HOH E 5 .   ? 2.15491   -16.75501 16.60466  1.000 12.46385 ? 574 HOH A O   1 
HETATM 2389 O O   . HOH E 5 .   ? 0.97603   -28.43927 25.82570  1.000 26.63335 ? 575 HOH A O   1 
HETATM 2390 O O   . HOH E 5 .   ? 12.02268  2.27703   22.21947  1.000 27.98367 ? 576 HOH A O   1 
HETATM 2391 O O   . HOH E 5 .   ? 12.94583  -1.26160  14.85453  1.000 14.20721 ? 577 HOH A O   1 
HETATM 2392 O O   . HOH E 5 .   ? -0.40472  14.01578  18.21055  1.000 22.15234 ? 578 HOH A O   1 
HETATM 2393 O O   . HOH E 5 .   ? 9.81968   -34.42465 20.37055  1.000 24.98619 ? 579 HOH A O   1 
HETATM 2394 O O   . HOH E 5 .   ? 18.75237  -2.47545  2.08396   1.000 29.61054 ? 580 HOH A O   1 
HETATM 2395 O O   . HOH E 5 .   ? -5.14127  11.48640  -2.87860  1.000 38.00109 ? 581 HOH A O   1 
HETATM 2396 O O   . HOH E 5 .   ? -0.56979  15.66461  6.19585   1.000 15.90051 ? 582 HOH A O   1 
HETATM 2397 O O   . HOH E 5 .   ? 23.25661  11.80280  4.04328   1.000 14.84207 ? 583 HOH A O   1 
HETATM 2398 O O   . HOH E 5 .   ? -1.53675  -4.79234  14.01242  1.000 34.81326 ? 584 HOH A O   1 
HETATM 2399 O O   . HOH E 5 .   ? 4.35527   4.39473   19.34523  1.000 24.56838 ? 585 HOH A O   1 
HETATM 2400 O O   . HOH E 5 .   ? 7.316     -32.175   -5.949    1.000 17.46724 ? 586 HOH A O   1 
HETATM 2401 O O   . HOH E 5 .   ? 1.58694   -26.24163 7.03946   1.000 31.09296 ? 587 HOH A O   1 
HETATM 2402 O O   . HOH E 5 .   ? 15.928    18.249    16.605    1.000 26.53161 ? 588 HOH A O   1 
HETATM 2403 O O   . HOH E 5 .   ? -5.97786  -28.25511 11.90271  1.000 32.34220 ? 589 HOH A O   1 
HETATM 2404 O O   . HOH E 5 .   ? 13.23870  -2.29127  17.58142  1.000 19.39573 ? 590 HOH A O   1 
HETATM 2405 O O   . HOH E 5 .   ? -5.04017  9.99714   14.87844  1.000 19.47719 ? 591 HOH A O   1 
HETATM 2406 O O   . HOH E 5 .   ? 20.72116  -26.64712 14.53175  1.000 25.50811 ? 592 HOH A O   1 
HETATM 2407 O O   . HOH E 5 .   ? 3.35548   -27.60332 29.53223  1.000 15.97887 ? 593 HOH A O   1 
HETATM 2408 O O   . HOH E 5 .   ? 21.06529  -23.55957 24.84140  1.000 27.08507 ? 594 HOH A O   1 
HETATM 2409 O O   . HOH E 5 .   ? 1.92718   19.21121  17.84039  1.000 13.96310 ? 595 HOH A O   1 
HETATM 2410 O O   . HOH E 5 .   ? 5.74096   20.37105  -2.07215  1.000 18.68794 ? 596 HOH A O   1 
HETATM 2411 O O   . HOH E 5 .   ? -2.15671  12.16133  17.26772  1.000 18.49743 ? 597 HOH A O   1 
HETATM 2412 O O   . HOH E 5 .   ? 16.14569  22.40386  11.94140  1.000 16.80210 ? 598 HOH A O   1 
HETATM 2413 O O   . HOH E 5 .   ? 8.10379   16.25417  -12.05452 1.000 25.49054 ? 599 HOH A O   1 
HETATM 2414 O O   . HOH E 5 .   ? 16.97148  18.10067  7.45912   1.000 19.10123 ? 600 HOH A O   1 
HETATM 2415 O O   . HOH E 5 .   ? 4.32268   -1.54975  18.86448  1.000 16.79176 ? 601 HOH A O   1 
HETATM 2416 O O   . HOH E 5 .   ? 15.04530  0.55849   20.40070  1.000 33.79492 ? 602 HOH A O   1 
HETATM 2417 O O   . HOH E 5 .   ? 5.33248   -28.36924 14.57489  1.000 25.82584 ? 603 HOH A O   1 
HETATM 2418 O O   . HOH E 5 .   ? 2.86348   -20.63385 30.14351  1.000 18.93265 ? 604 HOH A O   1 
HETATM 2419 O O   . HOH E 5 .   ? 22.48959  8.35745   17.25662  1.000 32.99044 ? 605 HOH A O   1 
HETATM 2420 O O   . HOH E 5 .   ? 0.37342   -21.22130 31.44191  1.000 21.96812 ? 606 HOH A O   1 
HETATM 2421 O O   . HOH E 5 .   ? 5.34070   -32.29382 3.79630   1.000 28.78089 ? 607 HOH A O   1 
HETATM 2422 O O   . HOH E 5 .   ? 10.44145  22.00231  5.56298   1.000 8.21830  ? 608 HOH A O   1 
HETATM 2423 O O   . HOH E 5 .   ? 18.81782  -16.15214 29.69244  1.000 25.88787 ? 609 HOH A O   1 
HETATM 2424 O O   . HOH E 5 .   ? 8.86045   13.75702  16.86439  1.000 17.10590 ? 610 HOH A O   1 
HETATM 2425 O O   . HOH E 5 .   ? 11.45049  -2.60047  -6.12849  1.000 20.15753 ? 611 HOH A O   1 
HETATM 2426 O O   . HOH E 5 .   ? 19.86839  -12.04049 12.38818  1.000 16.44173 ? 612 HOH A O   1 
HETATM 2427 O O   . HOH E 5 .   ? 6.32430   -27.05548 29.88328  1.000 10.32314 ? 613 HOH A O   1 
HETATM 2428 O O   . HOH E 5 .   ? 22.341    17.878    -10.333   1.000 12.14266 ? 614 HOH A O   1 
HETATM 2429 O O   . HOH E 5 .   ? 23.439    22.251    -8.765    1.000 12.98318 ? 615 HOH A O   1 
HETATM 2430 O O   . HOH E 5 .   ? 25.19568  8.88595   -4.79485  1.000 19.30122 ? 616 HOH A O   1 
HETATM 2431 O O   . HOH E 5 .   ? 16.40931  -13.24853 7.15458   1.000 24.32598 ? 617 HOH A O   1 
HETATM 2432 O O   . HOH E 5 .   ? 11.79875  4.48235   16.87249  1.000 17.46567 ? 618 HOH A O   1 
HETATM 2433 O O   . HOH E 5 .   ? -4.283    18.464    12.214    1.000 22.39060 ? 619 HOH A O   1 
HETATM 2434 O O   . HOH E 5 .   ? 1.19540   -27.03131 28.10648  1.000 17.85466 ? 620 HOH A O   1 
HETATM 2435 O O   . HOH E 5 .   ? 7.580     7.975     -12.454   1.000 25.30045 ? 621 HOH A O   1 
HETATM 2436 O O   . HOH E 5 .   ? 15.59310  -3.48831  18.87225  1.000 17.98758 ? 622 HOH A O   1 
HETATM 2437 O O   . HOH E 5 .   ? 6.72787   1.35163   19.33396  1.000 18.98801 ? 623 HOH A O   1 
HETATM 2438 O O   . HOH E 5 .   ? 17.90167  -18.83449 30.43978  1.000 28.26535 ? 624 HOH A O   1 
HETATM 2439 O O   . HOH E 5 .   ? 11.768    -24.227   36.248    1.000 13.74785 ? 625 HOH A O   1 
HETATM 2440 O O   . HOH E 5 .   ? 18.83778  15.79194  7.65401   1.000 20.45029 ? 626 HOH A O   1 
HETATM 2441 O O   . HOH E 5 .   ? 1.62267   -22.08367 24.55372  1.000 25.49871 ? 627 HOH A O   1 
HETATM 2442 O O   . HOH E 5 .   ? -4.83840  -11.06275 20.84917  1.000 35.43235 ? 628 HOH A O   1 
HETATM 2443 O O   . HOH E 5 .   ? 11.33320  -26.29426 10.99753  1.000 12.60464 ? 629 HOH A O   1 
HETATM 2444 O O   . HOH E 5 .   ? -3.033    13.687    -5.548    1.000 29.62531 ? 630 HOH A O   1 
HETATM 2445 O O   . HOH E 5 .   ? 4.41097   -31.45668 20.46003  1.000 28.98728 ? 631 HOH A O   1 
HETATM 2446 O O   . HOH E 5 .   ? 7.71434   -17.36005 36.02184  1.000 28.40506 ? 632 HOH A O   1 
HETATM 2447 O O   . HOH E 5 .   ? -3.70802  8.31948   -1.64662  1.000 32.05533 ? 633 HOH A O   1 
HETATM 2448 O O   . HOH E 5 .   ? -3.70901  -9.27592  18.95272  1.000 32.15118 ? 634 HOH A O   1 
HETATM 2449 O O   . HOH E 5 .   ? 18.63019  -21.24895 28.70305  1.000 17.88386 ? 635 HOH A O   1 
HETATM 2450 O O   . HOH E 5 .   ? 13.72822  1.58580   -6.38427  1.000 28.06428 ? 636 HOH A O   1 
HETATM 2451 O O   . HOH E 5 .   ? 21.10743  10.55426  18.70499  1.000 18.58979 ? 637 HOH A O   1 
HETATM 2452 O O   . HOH E 5 .   ? 10.84403  -0.87325  13.03981  1.000 10.20390 ? 638 HOH A O   1 
HETATM 2453 O O   . HOH E 5 .   ? 12.733    -36.695   -7.212    1.000 25.69009 ? 639 HOH A O   1 
HETATM 2454 O O   . HOH E 5 .   ? 9.14426   -5.19353  -6.96291  1.000 30.71958 ? 640 HOH A O   1 
HETATM 2455 O O   . HOH E 5 .   ? 13.72103  -5.18800  31.18618  1.000 27.88101 ? 641 HOH A O   1 
HETATM 2456 O O   . HOH E 5 .   ? 5.51871   -18.95468 36.56648  1.000 24.11385 ? 642 HOH A O   1 
HETATM 2457 O O   . HOH E 5 .   ? 17.19636  -9.35754  6.25212   1.000 34.14791 ? 643 HOH A O   1 
HETATM 2458 O O   . HOH E 5 .   ? -0.30497  19.83803  4.62751   1.000 20.16049 ? 644 HOH A O   1 
HETATM 2459 O O   . HOH E 5 .   ? 2.16087   6.36530   18.41830  1.000 16.78973 ? 645 HOH A O   1 
HETATM 2460 O O   . HOH E 5 .   ? 4.36790   12.02876  20.65603  1.000 19.99948 ? 646 HOH A O   1 
HETATM 2461 O O   . HOH E 5 .   ? 14.20635  -26.54502 28.96768  1.000 37.57937 ? 647 HOH A O   1 
HETATM 2462 O O   . HOH E 5 .   ? 11.47888  22.83582  13.91284  1.000 23.94418 ? 648 HOH A O   1 
HETATM 2463 O O   . HOH E 5 .   ? 1.70947   -13.21137 19.66133  1.000 14.54800 ? 649 HOH A O   1 
HETATM 2464 O O   . HOH E 5 .   ? 8.66098   13.05688  21.56139  1.000 27.03176 ? 650 HOH A O   1 
HETATM 2465 O O   . HOH E 5 .   ? 12.76165  -8.98781  0.00055   1.000 23.16937 ? 651 HOH A O   1 
HETATM 2466 O O   . HOH E 5 .   ? 11.98965  -3.29416  -3.44073  1.000 23.64013 ? 652 HOH A O   1 
HETATM 2467 O O   . HOH E 5 .   ? 11.03754  26.53482  -9.85838  1.000 30.84079 ? 653 HOH A O   1 
HETATM 2468 O O   . HOH E 5 .   ? 22.86020  -21.11529 16.66284  1.000 30.54987 ? 654 HOH A O   1 
HETATM 2469 O O   . HOH E 5 .   ? 6.714     -28.258   4.424     1.000 26.93308 ? 655 HOH A O   1 
HETATM 2470 O O   . HOH E 5 .   ? 10.57072  -1.08505  28.10578  1.000 25.99329 ? 656 HOH A O   1 
HETATM 2471 O O   . HOH E 5 .   ? 12.42083  -24.97036 29.58623  1.000 21.99692 ? 657 HOH A O   1 
HETATM 2472 O O   . HOH E 5 .   ? 10.06623  28.20365  -7.70077  1.000 31.99142 ? 658 HOH A O   1 
HETATM 2473 O O   . HOH E 5 .   ? 13.03348  5.19342   -9.63025  1.000 16.50187 ? 659 HOH A O   1 
HETATM 2474 O O   . HOH E 5 .   ? 11.21539  25.72268  0.19211   1.000 13.27810 ? 660 HOH A O   1 
HETATM 2475 O O   . HOH E 5 .   ? 4.14937   -21.08619 23.78901  1.000 13.70731 ? 661 HOH A O   1 
HETATM 2476 O O   . HOH E 5 .   ? 9.86522   20.03626  3.67478   1.000 6.63568  ? 662 HOH A O   1 
HETATM 2477 O O   . HOH E 5 .   ? -0.13646  -13.89900 17.54168  1.000 27.66677 ? 663 HOH A O   1 
HETATM 2478 O O   . HOH E 5 .   ? -0.15045  12.13740  -8.32529  1.000 23.56012 ? 664 HOH A O   1 
HETATM 2479 O O   . HOH E 5 .   ? 17.10860  -0.52232  14.12321  1.000 24.34788 ? 665 HOH A O   1 
HETATM 2480 O O   . HOH E 5 .   ? -2.61382  -0.97922  4.36981   1.000 36.87850 ? 666 HOH A O   1 
HETATM 2481 O O   . HOH E 5 .   ? 4.07020   -26.80601 34.24348  1.000 19.36804 ? 667 HOH A O   1 
HETATM 2482 O O   . HOH E 5 .   ? 12.98179  0.66876   24.28673  1.000 18.79736 ? 668 HOH A O   1 
HETATM 2483 O O   . HOH E 5 .   ? 14.08225  -1.50224  -5.24434  1.000 25.58331 ? 669 HOH A O   1 
HETATM 2484 O O   . HOH E 5 .   ? -0.30087  19.33002  7.53194   1.000 19.34030 ? 670 HOH A O   1 
HETATM 2485 O O   . HOH E 5 .   ? 19.63441  -0.09785  7.21857   1.000 33.84933 ? 671 HOH A O   1 
HETATM 2486 O O   . HOH E 5 .   ? 26.86683  23.96797  -1.66960  1.000 28.32938 ? 672 HOH A O   1 
HETATM 2487 O O   . HOH E 5 .   ? 26.56533  20.28650  -2.05698  1.000 18.64728 ? 673 HOH A O   1 
HETATM 2488 O O   . HOH E 5 .   ? 18.33716  -2.16588  11.55692  1.000 28.11201 ? 674 HOH A O   1 
HETATM 2489 O O   . HOH E 5 .   ? 1.03650   -6.27410  21.61088  1.000 16.14128 ? 675 HOH A O   1 
HETATM 2490 O O   . HOH E 5 .   ? 11.82201  16.18233  18.96033  1.000 31.96401 ? 676 HOH A O   1 
HETATM 2491 O O   . HOH E 5 .   ? 2.54396   -19.61067 27.71279  1.000 15.96470 ? 677 HOH A O   1 
HETATM 2492 O O   . HOH E 5 .   ? -2.17329  -7.70336  21.08422  1.000 32.53775 ? 678 HOH A O   1 
HETATM 2493 O O   . HOH E 5 .   ? 20.88416  28.22292  7.32126   1.000 30.05475 ? 679 HOH A O   1 
HETATM 2494 O O   . HOH E 5 .   ? 19.52260  -0.61130  -2.94011  1.000 22.54215 ? 680 HOH A O   1 
HETATM 2495 O O   . HOH E 5 .   ? 17.70079  34.48296  -0.69618  1.000 35.00972 ? 681 HOH A O   1 
HETATM 2496 O O   . HOH E 5 .   ? 8.433     -26.680   11.847    1.000 32.15971 ? 682 HOH A O   1 
HETATM 2497 O O   . HOH E 5 .   ? -4.072    -28.331   3.422     1.000 13.94335 ? 683 HOH A O   1 
HETATM 2498 O O   . HOH E 5 .   ? 14.031    -36.918   23.833    1.000 26.45666 ? 684 HOH A O   1 
HETATM 2499 O O   . HOH E 5 .   ? 24.38588  15.92508  -10.41140 1.000 22.14384 ? 685 HOH A O   1 
HETATM 2500 O O   . HOH E 5 .   ? 6.67711   24.00859  14.68909  1.000 28.76904 ? 686 HOH A O   1 
HETATM 2501 O O   . HOH E 5 .   ? 20.04285  -27.53755 24.82214  1.000 31.21477 ? 687 HOH A O   1 
HETATM 2502 O O   . HOH E 5 .   ? 9.40425   21.66955  -2.89292  1.000 11.65093 ? 688 HOH A O   1 
HETATM 2503 O O   . HOH E 5 .   ? 14.49349  31.99130  -2.27710  1.000 19.02331 ? 689 HOH A O   1 
HETATM 2504 O O   . HOH E 5 .   ? 3.73389   11.00320  11.99943  1.000 10.48867 ? 690 HOH A O   1 
HETATM 2505 O O   . HOH E 5 .   ? 0.34191   -6.40145  29.34927  1.000 24.14754 ? 691 HOH A O   1 
HETATM 2506 O O   . HOH E 5 .   ? 11.41747  0.08051   -6.72044  1.000 22.42189 ? 692 HOH A O   1 
HETATM 2507 O O   . HOH E 5 .   ? -4.59131  14.37446  13.23755  1.000 29.40418 ? 693 HOH A O   1 
HETATM 2508 O O   . HOH E 5 .   ? 20.239    16.828    -11.713   1.000 12.73970 ? 694 HOH A O   1 
HETATM 2509 O O   . HOH E 5 .   ? 5.042     -34.161   26.894    1.000 34.78920 ? 695 HOH A O   1 
HETATM 2510 O O   . HOH E 5 .   ? -4.904    14.135    7.445     1.000 30.80050 ? 696 HOH A O   1 
HETATM 2511 O O   . HOH E 5 .   ? -3.66849  1.00440   11.83072  1.000 21.78548 ? 697 HOH A O   1 
HETATM 2512 O O   . HOH E 5 .   ? 14.46633  31.45936  -5.89437  1.000 16.17824 ? 698 HOH A O   1 
HETATM 2513 O O   . HOH E 5 .   ? 17.40824  1.92999   13.26179  1.000 17.60739 ? 699 HOH A O   1 
HETATM 2514 O O   . HOH E 5 .   ? 20.55335  -24.35502 20.90553  1.000 19.27889 ? 700 HOH A O   1 
HETATM 2515 O O   . HOH E 5 .   ? 5.283     -35.150   0.378     1.000 18.46466 ? 701 HOH A O   1 
HETATM 2516 O O   . HOH E 5 .   ? 9.45414   -4.80652  -3.99369  1.000 18.59832 ? 702 HOH A O   1 
HETATM 2517 O O   . HOH E 5 .   ? 11.93104  28.70193  9.09543   1.000 25.88512 ? 703 HOH A O   1 
HETATM 2518 O O   . HOH E 5 .   ? 1.77628   -12.07153 32.14590  1.000 30.69172 ? 704 HOH A O   1 
HETATM 2519 O O   . HOH E 5 .   ? 0.63316   23.74651  1.49266   1.000 37.91029 ? 705 HOH A O   1 
HETATM 2520 O O   . HOH E 5 .   ? 12.52337  0.14482   26.86704  1.000 31.20678 ? 706 HOH A O   1 
HETATM 2521 O O   . HOH E 5 .   ? 8.429     0.245     -13.809   1.000 29.15302 ? 707 HOH A O   1 
HETATM 2522 O O   . HOH E 5 .   ? 19.12295  19.16042  12.15052  1.000 27.32795 ? 708 HOH A O   1 
HETATM 2523 O O   . HOH E 5 .   ? 18.60315  23.23775  11.33062  1.000 22.65706 ? 709 HOH A O   1 
HETATM 2524 O O   . HOH E 5 .   ? -1.87375  -4.06968  22.96885  1.000 30.36747 ? 710 HOH A O   1 
HETATM 2525 O O   . HOH E 5 .   ? 28.51519  21.59695  -3.02586  1.000 33.62302 ? 711 HOH A O   1 
HETATM 2526 O O   . HOH E 5 .   ? 2.18755   -1.44732  -9.10591  1.000 34.89995 ? 712 HOH A O   1 
HETATM 2527 O O   . HOH E 5 .   ? 12.70766  20.38123  -12.63336 1.000 24.71995 ? 713 HOH A O   1 
HETATM 2528 O O   . HOH E 5 .   ? 26.79578  15.58391  -4.62247  1.000 32.07061 ? 714 HOH A O   1 
HETATM 2529 O O   . HOH E 5 .   ? 0.90607   -22.08426 27.10304  1.000 34.10798 ? 715 HOH A O   1 
HETATM 2530 O O   . HOH E 5 .   ? 8.85769   -9.31526  -2.41726  1.000 30.22299 ? 716 HOH A O   1 
HETATM 2531 O O   . HOH E 5 .   ? 5.502     -37.500   -12.709   1.000 37.71609 ? 717 HOH A O   1 
HETATM 2532 O O   . HOH E 5 .   ? 13.098    -25.248   32.032    1.000 32.25396 ? 718 HOH A O   1 
HETATM 2533 O O   . HOH E 5 .   ? -1.14618  -20.58041 21.07791  1.000 30.98838 ? 719 HOH A O   1 
HETATM 2534 O O   . HOH E 5 .   ? 2.85573   -21.88527 10.95539  1.000 30.66501 ? 720 HOH A O   1 
HETATM 2535 O O   . HOH E 5 .   ? 16.68269  -5.37422  31.79150  1.000 34.12676 ? 721 HOH A O   1 
HETATM 2536 O O   . HOH E 5 .   ? 5.46349   -0.46410  21.05921  1.000 23.06385 ? 722 HOH A O   1 
HETATM 2537 O O   . HOH E 5 .   ? -1.48252  -19.56671 31.32169  1.000 32.22334 ? 723 HOH A O   1 
HETATM 2538 O O   . HOH E 5 .   ? 3.55015   28.70032  7.59599   1.000 29.29188 ? 724 HOH A O   1 
HETATM 2539 O O   . HOH E 5 .   ? -0.66378  -20.54810 23.55540  1.000 28.12636 ? 725 HOH A O   1 
HETATM 2540 O O   . HOH E 5 .   ? 10.29267  -7.45896  -4.40924  1.000 39.19421 ? 726 HOH A O   1 
HETATM 2541 O O   . HOH E 5 .   ? 18.419    -26.662   26.211    1.000 41.74076 ? 727 HOH A O   1 
HETATM 2542 O O   . HOH E 5 .   ? 10.63510  -14.50373 0.90651   1.000 41.03001 ? 728 HOH A O   1 
HETATM 2543 O O   . HOH E 5 .   ? 17.39686  3.58699   15.29286  1.000 32.57550 ? 729 HOH A O   1 
HETATM 2544 O O   . HOH E 5 .   ? 15.10166  30.92574  0.50475   1.000 33.99230 ? 730 HOH A O   1 
HETATM 2545 O O   . HOH E 5 .   ? 0.44207   -17.96852 27.12461  1.000 39.11555 ? 731 HOH A O   1 
HETATM 2546 O O   . HOH E 5 .   ? -7.928    10.888    -4.737    1.000 32.05958 ? 732 HOH A O   1 
HETATM 2547 O O   . HOH E 5 .   ? 11.83862  29.16745  5.66091   1.000 36.63975 ? 733 HOH A O   1 
HETATM 2548 O O   . HOH E 5 .   ? 11.89548  24.89843  12.12575  1.000 35.27852 ? 734 HOH A O   1 
HETATM 2549 O O   . HOH E 5 .   ? 2.88392   23.99803  16.93829  1.000 33.43967 ? 735 HOH A O   1 
HETATM 2550 O O   . HOH E 5 .   ? 14.04137  4.95129   16.48589  1.000 34.20686 ? 736 HOH A O   1 
HETATM 2551 O O   . HOH E 5 .   ? 4.36362   1.47035   22.21347  1.000 28.49743 ? 737 HOH A O   1 
HETATM 2552 O O   . HOH E 5 .   ? 6.70937   24.81892  -1.15259  1.000 28.35080 ? 738 HOH A O   1 
HETATM 2553 O O   . HOH E 5 .   ? 25.69048  7.69312   -2.24898  1.000 37.65472 ? 739 HOH A O   1 
HETATM 2554 O O   . HOH E 5 .   ? -1.44866  -2.49298  13.46895  1.000 25.97647 ? 740 HOH A O   1 
HETATM 2555 O O   . HOH E 5 .   ? 1.09444   23.27250  18.27688  1.000 36.71769 ? 741 HOH A O   1 
HETATM 2556 O O   . HOH E 5 .   ? 2.49649   -6.75193  31.04916  1.000 24.11721 ? 742 HOH A O   1 
HETATM 2557 O O   . HOH E 5 .   ? -2.406    -26.128   2.611     1.000 28.10431 ? 743 HOH A O   1 
HETATM 2558 O O   . HOH E 5 .   ? 9.08608   24.56808  11.97823  1.000 34.47160 ? 744 HOH A O   1 
HETATM 2559 O O   . HOH E 5 .   ? 15.40934  4.32139   -7.67931  1.000 29.08356 ? 745 HOH A O   1 
HETATM 2560 O O   . HOH E 5 .   ? 27.22653  21.85844  0.55704   1.000 33.85479 ? 746 HOH A O   1 
HETATM 2561 O O   . HOH E 5 .   ? 20.25267  -28.10022 18.36078  1.000 30.39819 ? 747 HOH A O   1 
HETATM 2562 O O   . HOH E 5 .   ? 0.87311   -9.02130  32.16771  1.000 37.05738 ? 748 HOH A O   1 
HETATM 2563 O O   . HOH E 5 .   ? 19.727    -24.527   28.755    1.000 38.59700 ? 749 HOH A O   1 
HETATM 2564 O O   . HOH E 5 .   ? 12.93016  27.65347  -0.03202  1.000 24.01018 ? 750 HOH A O   1 
HETATM 2565 O O   . HOH E 5 .   ? -5.95393  12.76654  14.98225  1.000 33.21082 ? 751 HOH A O   1 
HETATM 2566 O O   . HOH E 5 .   ? 20.64276  -16.16516 27.97252  1.000 32.25718 ? 752 HOH A O   1 
HETATM 2567 O O   . HOH E 5 .   ? 1.99384   18.70317  20.63483  1.000 33.90375 ? 753 HOH A O   1 
HETATM 2568 O O   . HOH E 5 .   ? -1.39877  -5.58428  20.44073  1.000 30.17269 ? 754 HOH A O   1 
HETATM 2569 O O   . HOH E 5 .   ? 19.051    -22.844   31.020    1.000 32.64393 ? 755 HOH A O   1 
HETATM 2570 O O   . HOH E 5 .   ? 33.564    22.141    3.849     1.000 33.45828 ? 756 HOH A O   1 
HETATM 2571 O O   . HOH E 5 .   ? 19.62735  -0.09170  9.47634   1.000 32.49292 ? 757 HOH A O   1 
HETATM 2572 O O   . HOH E 5 .   ? -5.54195  16.07113  11.67611  1.000 31.10723 ? 758 HOH A O   1 
HETATM 2573 O O   . HOH E 5 .   ? 5.896     9.748     -12.552   1.000 33.81480 ? 759 HOH A O   1 
HETATM 2574 O O   . HOH E 5 .   ? 3.802     -37.008   26.384    1.000 37.51924 ? 760 HOH A O   1 
HETATM 2575 O O   . HOH E 5 .   ? 7.80049   27.28767  8.92221   1.000 30.50801 ? 761 HOH A O   1 
HETATM 2576 O O   . HOH E 5 .   ? -2.97928  10.32094  19.41724  1.000 35.80000 ? 762 HOH A O   1 
HETATM 2577 O O   . HOH E 5 .   ? 18.74320  -1.49241  16.10838  1.000 36.61713 ? 763 HOH A O   1 
HETATM 2578 O O   . HOH E 5 .   ? 11.60975  32.52716  -1.43485  1.000 35.03710 ? 764 HOH A O   1 
HETATM 2579 O O   . HOH E 5 .   ? 3.58916   -8.16435  -1.54389  1.000 37.15875 ? 765 HOH A O   1 
# 
