data_9HT4
# 
_entry.id   9HT4 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.401 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9HT4         pdb_00009ht4 10.2210/pdb9ht4/pdb 
WWPDB D_1292143776 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-02-05 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9HT4 
_pdbx_database_status.recvd_initial_deposition_date   2024-12-19 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              gavin.thomas@york.ac.uk 
_pdbx_contact_author.name_first         Gavin 
_pdbx_contact_author.name_last          Thomas 
_pdbx_contact_author.name_mi            H 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-9763-1313 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Herman, R.'               1 0000-0002-6620-3981 
'Mehboob, J.'              2 0000-0002-2777-3228 
'Elston, R.'               3 0000-0003-1856-2696 
'Afolabi, H.'              4 0009-0003-0208-3241 
'Kinniment-Williams, B.E.' 5 0009-0001-9809-4134 
'Wilkinson, A.J.'          6 0000-0003-4577-9479 
'Thomas, G.H.'             7 0000-0002-9763-1313 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'PA0884 is part of a high-affinity itaconate TRAP transporter in Pseudomonas aeruginosa' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Herman, R.'               1 ? 
primary 'Mehboob, J.M.'            2 ? 
primary 'Elston, R.'               3 ? 
primary 'Afolabi, H.'              4 ? 
primary 'Kinniment-Williams, B.E.' 5 ? 
primary 'Wilkinson, A.J.'          6 ? 
primary 'Thomas, G.H.'             7 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Probable C4-dicarboxylate-binding periplasmic protein' 34935.547 2   ? ? ? ? 
2 non-polymer syn 'SUCCINIC ACID'                                         118.088   2   ? ? ? ? 
3 water       nat water                                                   18.015    320 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;AQPIVIKFSHVVAENTPKGQGALLFKKLVEQRLGGRVEVDVYPNSSLFGDGKEMEALLLGDVQMLAPSLAKFEQYTRKVQ
IFDLPFLFDDIQAVDRFQRSPQGRALLTSMQGKGILGLAYWHNGMKQLSANRPLLEPEDARGLKFRVQASDVLNEQFRQL
RAISRKMSFAEVYQGLQTGVVNGTENTWSNYESQKVNEVQKYFTESNHGLVDYMVITNAKFWNGLPADIREELQRIMDEV
TVQVNLEAERLNRDARQRILASGASEIHTLSPQQRADWRQAMQPVWQKFRGNVGADLLQAAEASNRPD
;
_entity_poly.pdbx_seq_one_letter_code_can   
;AQPIVIKFSHVVAENTPKGQGALLFKKLVEQRLGGRVEVDVYPNSSLFGDGKEMEALLLGDVQMLAPSLAKFEQYTRKVQ
IFDLPFLFDDIQAVDRFQRSPQGRALLTSMQGKGILGLAYWHNGMKQLSANRPLLEPEDARGLKFRVQASDVLNEQFRQL
RAISRKMSFAEVYQGLQTGVVNGTENTWSNYESQKVNEVQKYFTESNHGLVDYMVITNAKFWNGLPADIREELQRIMDEV
TVQVNLEAERLNRDARQRILASGASEIHTLSPQQRADWRQAMQPVWQKFRGNVGADLLQAAEASNRPD
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'SUCCINIC ACID' SIN 
3 water           HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   ALA n 
1 2   GLN n 
1 3   PRO n 
1 4   ILE n 
1 5   VAL n 
1 6   ILE n 
1 7   LYS n 
1 8   PHE n 
1 9   SER n 
1 10  HIS n 
1 11  VAL n 
1 12  VAL n 
1 13  ALA n 
1 14  GLU n 
1 15  ASN n 
1 16  THR n 
1 17  PRO n 
1 18  LYS n 
1 19  GLY n 
1 20  GLN n 
1 21  GLY n 
1 22  ALA n 
1 23  LEU n 
1 24  LEU n 
1 25  PHE n 
1 26  LYS n 
1 27  LYS n 
1 28  LEU n 
1 29  VAL n 
1 30  GLU n 
1 31  GLN n 
1 32  ARG n 
1 33  LEU n 
1 34  GLY n 
1 35  GLY n 
1 36  ARG n 
1 37  VAL n 
1 38  GLU n 
1 39  VAL n 
1 40  ASP n 
1 41  VAL n 
1 42  TYR n 
1 43  PRO n 
1 44  ASN n 
1 45  SER n 
1 46  SER n 
1 47  LEU n 
1 48  PHE n 
1 49  GLY n 
1 50  ASP n 
1 51  GLY n 
1 52  LYS n 
1 53  GLU n 
1 54  MET n 
1 55  GLU n 
1 56  ALA n 
1 57  LEU n 
1 58  LEU n 
1 59  LEU n 
1 60  GLY n 
1 61  ASP n 
1 62  VAL n 
1 63  GLN n 
1 64  MET n 
1 65  LEU n 
1 66  ALA n 
1 67  PRO n 
1 68  SER n 
1 69  LEU n 
1 70  ALA n 
1 71  LYS n 
1 72  PHE n 
1 73  GLU n 
1 74  GLN n 
1 75  TYR n 
1 76  THR n 
1 77  ARG n 
1 78  LYS n 
1 79  VAL n 
1 80  GLN n 
1 81  ILE n 
1 82  PHE n 
1 83  ASP n 
1 84  LEU n 
1 85  PRO n 
1 86  PHE n 
1 87  LEU n 
1 88  PHE n 
1 89  ASP n 
1 90  ASP n 
1 91  ILE n 
1 92  GLN n 
1 93  ALA n 
1 94  VAL n 
1 95  ASP n 
1 96  ARG n 
1 97  PHE n 
1 98  GLN n 
1 99  ARG n 
1 100 SER n 
1 101 PRO n 
1 102 GLN n 
1 103 GLY n 
1 104 ARG n 
1 105 ALA n 
1 106 LEU n 
1 107 LEU n 
1 108 THR n 
1 109 SER n 
1 110 MET n 
1 111 GLN n 
1 112 GLY n 
1 113 LYS n 
1 114 GLY n 
1 115 ILE n 
1 116 LEU n 
1 117 GLY n 
1 118 LEU n 
1 119 ALA n 
1 120 TYR n 
1 121 TRP n 
1 122 HIS n 
1 123 ASN n 
1 124 GLY n 
1 125 MET n 
1 126 LYS n 
1 127 GLN n 
1 128 LEU n 
1 129 SER n 
1 130 ALA n 
1 131 ASN n 
1 132 ARG n 
1 133 PRO n 
1 134 LEU n 
1 135 LEU n 
1 136 GLU n 
1 137 PRO n 
1 138 GLU n 
1 139 ASP n 
1 140 ALA n 
1 141 ARG n 
1 142 GLY n 
1 143 LEU n 
1 144 LYS n 
1 145 PHE n 
1 146 ARG n 
1 147 VAL n 
1 148 GLN n 
1 149 ALA n 
1 150 SER n 
1 151 ASP n 
1 152 VAL n 
1 153 LEU n 
1 154 ASN n 
1 155 GLU n 
1 156 GLN n 
1 157 PHE n 
1 158 ARG n 
1 159 GLN n 
1 160 LEU n 
1 161 ARG n 
1 162 ALA n 
1 163 ILE n 
1 164 SER n 
1 165 ARG n 
1 166 LYS n 
1 167 MET n 
1 168 SER n 
1 169 PHE n 
1 170 ALA n 
1 171 GLU n 
1 172 VAL n 
1 173 TYR n 
1 174 GLN n 
1 175 GLY n 
1 176 LEU n 
1 177 GLN n 
1 178 THR n 
1 179 GLY n 
1 180 VAL n 
1 181 VAL n 
1 182 ASN n 
1 183 GLY n 
1 184 THR n 
1 185 GLU n 
1 186 ASN n 
1 187 THR n 
1 188 TRP n 
1 189 SER n 
1 190 ASN n 
1 191 TYR n 
1 192 GLU n 
1 193 SER n 
1 194 GLN n 
1 195 LYS n 
1 196 VAL n 
1 197 ASN n 
1 198 GLU n 
1 199 VAL n 
1 200 GLN n 
1 201 LYS n 
1 202 TYR n 
1 203 PHE n 
1 204 THR n 
1 205 GLU n 
1 206 SER n 
1 207 ASN n 
1 208 HIS n 
1 209 GLY n 
1 210 LEU n 
1 211 VAL n 
1 212 ASP n 
1 213 TYR n 
1 214 MET n 
1 215 VAL n 
1 216 ILE n 
1 217 THR n 
1 218 ASN n 
1 219 ALA n 
1 220 LYS n 
1 221 PHE n 
1 222 TRP n 
1 223 ASN n 
1 224 GLY n 
1 225 LEU n 
1 226 PRO n 
1 227 ALA n 
1 228 ASP n 
1 229 ILE n 
1 230 ARG n 
1 231 GLU n 
1 232 GLU n 
1 233 LEU n 
1 234 GLN n 
1 235 ARG n 
1 236 ILE n 
1 237 MET n 
1 238 ASP n 
1 239 GLU n 
1 240 VAL n 
1 241 THR n 
1 242 VAL n 
1 243 GLN n 
1 244 VAL n 
1 245 ASN n 
1 246 LEU n 
1 247 GLU n 
1 248 ALA n 
1 249 GLU n 
1 250 ARG n 
1 251 LEU n 
1 252 ASN n 
1 253 ARG n 
1 254 ASP n 
1 255 ALA n 
1 256 ARG n 
1 257 GLN n 
1 258 ARG n 
1 259 ILE n 
1 260 LEU n 
1 261 ALA n 
1 262 SER n 
1 263 GLY n 
1 264 ALA n 
1 265 SER n 
1 266 GLU n 
1 267 ILE n 
1 268 HIS n 
1 269 THR n 
1 270 LEU n 
1 271 SER n 
1 272 PRO n 
1 273 GLN n 
1 274 GLN n 
1 275 ARG n 
1 276 ALA n 
1 277 ASP n 
1 278 TRP n 
1 279 ARG n 
1 280 GLN n 
1 281 ALA n 
1 282 MET n 
1 283 GLN n 
1 284 PRO n 
1 285 VAL n 
1 286 TRP n 
1 287 GLN n 
1 288 LYS n 
1 289 PHE n 
1 290 ARG n 
1 291 GLY n 
1 292 ASN n 
1 293 VAL n 
1 294 GLY n 
1 295 ALA n 
1 296 ASP n 
1 297 LEU n 
1 298 LEU n 
1 299 GLN n 
1 300 ALA n 
1 301 ALA n 
1 302 GLU n 
1 303 ALA n 
1 304 SER n 
1 305 ASN n 
1 306 ARG n 
1 307 PRO n 
1 308 ASP n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   308 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 PA0884 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Pseudomonas aeruginosa PAO1' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     208964 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
SIN non-polymer         . 'SUCCINIC ACID' ? 'C4 H6 O4'       118.088 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   ALA 1   24  ?   ?   ?   A . n 
A 1 2   GLN 2   25  ?   ?   ?   A . n 
A 1 3   PRO 3   26  26  PRO PRO A . n 
A 1 4   ILE 4   27  27  ILE ILE A . n 
A 1 5   VAL 5   28  28  VAL VAL A . n 
A 1 6   ILE 6   29  29  ILE ILE A . n 
A 1 7   LYS 7   30  30  LYS LYS A . n 
A 1 8   PHE 8   31  31  PHE PHE A . n 
A 1 9   SER 9   32  32  SER SER A . n 
A 1 10  HIS 10  33  33  HIS HIS A . n 
A 1 11  VAL 11  34  34  VAL VAL A . n 
A 1 12  VAL 12  35  35  VAL VAL A . n 
A 1 13  ALA 13  36  36  ALA ALA A . n 
A 1 14  GLU 14  37  37  GLU GLU A . n 
A 1 15  ASN 15  38  38  ASN ASN A . n 
A 1 16  THR 16  39  39  THR THR A . n 
A 1 17  PRO 17  40  40  PRO PRO A . n 
A 1 18  LYS 18  41  41  LYS LYS A . n 
A 1 19  GLY 19  42  42  GLY GLY A . n 
A 1 20  GLN 20  43  43  GLN GLN A . n 
A 1 21  GLY 21  44  44  GLY GLY A . n 
A 1 22  ALA 22  45  45  ALA ALA A . n 
A 1 23  LEU 23  46  46  LEU LEU A . n 
A 1 24  LEU 24  47  47  LEU LEU A . n 
A 1 25  PHE 25  48  48  PHE PHE A . n 
A 1 26  LYS 26  49  49  LYS LYS A . n 
A 1 27  LYS 27  50  50  LYS LYS A . n 
A 1 28  LEU 28  51  51  LEU LEU A . n 
A 1 29  VAL 29  52  52  VAL VAL A . n 
A 1 30  GLU 30  53  53  GLU GLU A . n 
A 1 31  GLN 31  54  54  GLN GLN A . n 
A 1 32  ARG 32  55  55  ARG ARG A . n 
A 1 33  LEU 33  56  56  LEU LEU A . n 
A 1 34  GLY 34  57  57  GLY GLY A . n 
A 1 35  GLY 35  58  58  GLY GLY A . n 
A 1 36  ARG 36  59  59  ARG ARG A . n 
A 1 37  VAL 37  60  60  VAL VAL A . n 
A 1 38  GLU 38  61  61  GLU GLU A . n 
A 1 39  VAL 39  62  62  VAL VAL A . n 
A 1 40  ASP 40  63  63  ASP ASP A . n 
A 1 41  VAL 41  64  64  VAL VAL A . n 
A 1 42  TYR 42  65  65  TYR TYR A . n 
A 1 43  PRO 43  66  66  PRO PRO A . n 
A 1 44  ASN 44  67  67  ASN ASN A . n 
A 1 45  SER 45  68  68  SER SER A . n 
A 1 46  SER 46  69  69  SER SER A . n 
A 1 47  LEU 47  70  70  LEU LEU A . n 
A 1 48  PHE 48  71  71  PHE PHE A . n 
A 1 49  GLY 49  72  72  GLY GLY A . n 
A 1 50  ASP 50  73  73  ASP ASP A . n 
A 1 51  GLY 51  74  74  GLY GLY A . n 
A 1 52  LYS 52  75  75  LYS LYS A . n 
A 1 53  GLU 53  76  76  GLU GLU A . n 
A 1 54  MET 54  77  77  MET MET A . n 
A 1 55  GLU 55  78  78  GLU GLU A . n 
A 1 56  ALA 56  79  79  ALA ALA A . n 
A 1 57  LEU 57  80  80  LEU LEU A . n 
A 1 58  LEU 58  81  81  LEU LEU A . n 
A 1 59  LEU 59  82  82  LEU LEU A . n 
A 1 60  GLY 60  83  83  GLY GLY A . n 
A 1 61  ASP 61  84  84  ASP ASP A . n 
A 1 62  VAL 62  85  85  VAL VAL A . n 
A 1 63  GLN 63  86  86  GLN GLN A . n 
A 1 64  MET 64  87  87  MET MET A . n 
A 1 65  LEU 65  88  88  LEU LEU A . n 
A 1 66  ALA 66  89  89  ALA ALA A . n 
A 1 67  PRO 67  90  90  PRO PRO A . n 
A 1 68  SER 68  91  91  SER SER A . n 
A 1 69  LEU 69  92  92  LEU LEU A . n 
A 1 70  ALA 70  93  93  ALA ALA A . n 
A 1 71  LYS 71  94  94  LYS LYS A . n 
A 1 72  PHE 72  95  95  PHE PHE A . n 
A 1 73  GLU 73  96  96  GLU GLU A . n 
A 1 74  GLN 74  97  97  GLN GLN A . n 
A 1 75  TYR 75  98  98  TYR TYR A . n 
A 1 76  THR 76  99  99  THR THR A . n 
A 1 77  ARG 77  100 100 ARG ARG A . n 
A 1 78  LYS 78  101 101 LYS LYS A . n 
A 1 79  VAL 79  102 102 VAL VAL A . n 
A 1 80  GLN 80  103 103 GLN GLN A . n 
A 1 81  ILE 81  104 104 ILE ILE A . n 
A 1 82  PHE 82  105 105 PHE PHE A . n 
A 1 83  ASP 83  106 106 ASP ASP A . n 
A 1 84  LEU 84  107 107 LEU LEU A . n 
A 1 85  PRO 85  108 108 PRO PRO A . n 
A 1 86  PHE 86  109 109 PHE PHE A . n 
A 1 87  LEU 87  110 110 LEU LEU A . n 
A 1 88  PHE 88  111 111 PHE PHE A . n 
A 1 89  ASP 89  112 112 ASP ASP A . n 
A 1 90  ASP 90  113 113 ASP ASP A . n 
A 1 91  ILE 91  114 114 ILE ILE A . n 
A 1 92  GLN 92  115 115 GLN GLN A . n 
A 1 93  ALA 93  116 116 ALA ALA A . n 
A 1 94  VAL 94  117 117 VAL VAL A . n 
A 1 95  ASP 95  118 118 ASP ASP A . n 
A 1 96  ARG 96  119 119 ARG ARG A . n 
A 1 97  PHE 97  120 120 PHE PHE A . n 
A 1 98  GLN 98  121 121 GLN GLN A . n 
A 1 99  ARG 99  122 122 ARG ARG A . n 
A 1 100 SER 100 123 123 SER SER A . n 
A 1 101 PRO 101 124 124 PRO PRO A . n 
A 1 102 GLN 102 125 125 GLN GLN A . n 
A 1 103 GLY 103 126 126 GLY GLY A . n 
A 1 104 ARG 104 127 127 ARG ARG A . n 
A 1 105 ALA 105 128 128 ALA ALA A . n 
A 1 106 LEU 106 129 129 LEU LEU A . n 
A 1 107 LEU 107 130 130 LEU LEU A . n 
A 1 108 THR 108 131 131 THR THR A . n 
A 1 109 SER 109 132 132 SER SER A . n 
A 1 110 MET 110 133 133 MET MET A . n 
A 1 111 GLN 111 134 134 GLN GLN A . n 
A 1 112 GLY 112 135 135 GLY GLY A . n 
A 1 113 LYS 113 136 136 LYS LYS A . n 
A 1 114 GLY 114 137 137 GLY GLY A . n 
A 1 115 ILE 115 138 138 ILE ILE A . n 
A 1 116 LEU 116 139 139 LEU LEU A . n 
A 1 117 GLY 117 140 140 GLY GLY A . n 
A 1 118 LEU 118 141 141 LEU LEU A . n 
A 1 119 ALA 119 142 142 ALA ALA A . n 
A 1 120 TYR 120 143 143 TYR TYR A . n 
A 1 121 TRP 121 144 144 TRP TRP A . n 
A 1 122 HIS 122 145 145 HIS HIS A . n 
A 1 123 ASN 123 146 146 ASN ASN A . n 
A 1 124 GLY 124 147 147 GLY GLY A . n 
A 1 125 MET 125 148 148 MET MET A . n 
A 1 126 LYS 126 149 149 LYS LYS A . n 
A 1 127 GLN 127 150 150 GLN GLN A . n 
A 1 128 LEU 128 151 151 LEU LEU A . n 
A 1 129 SER 129 152 152 SER SER A . n 
A 1 130 ALA 130 153 153 ALA ALA A . n 
A 1 131 ASN 131 154 154 ASN ASN A . n 
A 1 132 ARG 132 155 155 ARG ARG A . n 
A 1 133 PRO 133 156 156 PRO PRO A . n 
A 1 134 LEU 134 157 157 LEU LEU A . n 
A 1 135 LEU 135 158 158 LEU LEU A . n 
A 1 136 GLU 136 159 159 GLU GLU A . n 
A 1 137 PRO 137 160 160 PRO PRO A . n 
A 1 138 GLU 138 161 161 GLU GLU A . n 
A 1 139 ASP 139 162 162 ASP ASP A . n 
A 1 140 ALA 140 163 163 ALA ALA A . n 
A 1 141 ARG 141 164 164 ARG ARG A . n 
A 1 142 GLY 142 165 165 GLY GLY A . n 
A 1 143 LEU 143 166 166 LEU LEU A . n 
A 1 144 LYS 144 167 167 LYS LYS A . n 
A 1 145 PHE 145 168 168 PHE PHE A . n 
A 1 146 ARG 146 169 169 ARG ARG A . n 
A 1 147 VAL 147 170 170 VAL VAL A . n 
A 1 148 GLN 148 171 171 GLN GLN A . n 
A 1 149 ALA 149 172 172 ALA ALA A . n 
A 1 150 SER 150 173 173 SER SER A . n 
A 1 151 ASP 151 174 174 ASP ASP A . n 
A 1 152 VAL 152 175 175 VAL VAL A . n 
A 1 153 LEU 153 176 176 LEU LEU A . n 
A 1 154 ASN 154 177 177 ASN ASN A . n 
A 1 155 GLU 155 178 178 GLU GLU A . n 
A 1 156 GLN 156 179 179 GLN GLN A . n 
A 1 157 PHE 157 180 180 PHE PHE A . n 
A 1 158 ARG 158 181 181 ARG ARG A . n 
A 1 159 GLN 159 182 182 GLN GLN A . n 
A 1 160 LEU 160 183 183 LEU LEU A . n 
A 1 161 ARG 161 184 184 ARG ARG A . n 
A 1 162 ALA 162 185 185 ALA ALA A . n 
A 1 163 ILE 163 186 186 ILE ILE A . n 
A 1 164 SER 164 187 187 SER SER A . n 
A 1 165 ARG 165 188 188 ARG ARG A . n 
A 1 166 LYS 166 189 189 LYS LYS A . n 
A 1 167 MET 167 190 190 MET MET A . n 
A 1 168 SER 168 191 191 SER SER A . n 
A 1 169 PHE 169 192 192 PHE PHE A . n 
A 1 170 ALA 170 193 193 ALA ALA A . n 
A 1 171 GLU 171 194 194 GLU GLU A . n 
A 1 172 VAL 172 195 195 VAL VAL A . n 
A 1 173 TYR 173 196 196 TYR TYR A . n 
A 1 174 GLN 174 197 197 GLN GLN A . n 
A 1 175 GLY 175 198 198 GLY GLY A . n 
A 1 176 LEU 176 199 199 LEU LEU A . n 
A 1 177 GLN 177 200 200 GLN GLN A . n 
A 1 178 THR 178 201 201 THR THR A . n 
A 1 179 GLY 179 202 202 GLY GLY A . n 
A 1 180 VAL 180 203 203 VAL VAL A . n 
A 1 181 VAL 181 204 204 VAL VAL A . n 
A 1 182 ASN 182 205 205 ASN ASN A . n 
A 1 183 GLY 183 206 206 GLY GLY A . n 
A 1 184 THR 184 207 207 THR THR A . n 
A 1 185 GLU 185 208 208 GLU GLU A . n 
A 1 186 ASN 186 209 209 ASN ASN A . n 
A 1 187 THR 187 210 210 THR THR A . n 
A 1 188 TRP 188 211 211 TRP TRP A . n 
A 1 189 SER 189 212 212 SER SER A . n 
A 1 190 ASN 190 213 213 ASN ASN A . n 
A 1 191 TYR 191 214 214 TYR TYR A . n 
A 1 192 GLU 192 215 215 GLU GLU A . n 
A 1 193 SER 193 216 216 SER SER A . n 
A 1 194 GLN 194 217 217 GLN GLN A . n 
A 1 195 LYS 195 218 218 LYS LYS A . n 
A 1 196 VAL 196 219 219 VAL VAL A . n 
A 1 197 ASN 197 220 220 ASN ASN A . n 
A 1 198 GLU 198 221 221 GLU GLU A . n 
A 1 199 VAL 199 222 222 VAL VAL A . n 
A 1 200 GLN 200 223 223 GLN GLN A . n 
A 1 201 LYS 201 224 224 LYS LYS A . n 
A 1 202 TYR 202 225 225 TYR TYR A . n 
A 1 203 PHE 203 226 226 PHE PHE A . n 
A 1 204 THR 204 227 227 THR THR A . n 
A 1 205 GLU 205 228 228 GLU GLU A . n 
A 1 206 SER 206 229 229 SER SER A . n 
A 1 207 ASN 207 230 230 ASN ASN A . n 
A 1 208 HIS 208 231 231 HIS HIS A . n 
A 1 209 GLY 209 232 232 GLY GLY A . n 
A 1 210 LEU 210 233 233 LEU LEU A . n 
A 1 211 VAL 211 234 234 VAL VAL A . n 
A 1 212 ASP 212 235 235 ASP ASP A . n 
A 1 213 TYR 213 236 236 TYR TYR A . n 
A 1 214 MET 214 237 237 MET MET A . n 
A 1 215 VAL 215 238 238 VAL VAL A . n 
A 1 216 ILE 216 239 239 ILE ILE A . n 
A 1 217 THR 217 240 240 THR THR A . n 
A 1 218 ASN 218 241 241 ASN ASN A . n 
A 1 219 ALA 219 242 242 ALA ALA A . n 
A 1 220 LYS 220 243 243 LYS LYS A . n 
A 1 221 PHE 221 244 244 PHE PHE A . n 
A 1 222 TRP 222 245 245 TRP TRP A . n 
A 1 223 ASN 223 246 246 ASN ASN A . n 
A 1 224 GLY 224 247 247 GLY GLY A . n 
A 1 225 LEU 225 248 248 LEU LEU A . n 
A 1 226 PRO 226 249 249 PRO PRO A . n 
A 1 227 ALA 227 250 250 ALA ALA A . n 
A 1 228 ASP 228 251 251 ASP ASP A . n 
A 1 229 ILE 229 252 252 ILE ILE A . n 
A 1 230 ARG 230 253 253 ARG ARG A . n 
A 1 231 GLU 231 254 254 GLU GLU A . n 
A 1 232 GLU 232 255 255 GLU GLU A . n 
A 1 233 LEU 233 256 256 LEU LEU A . n 
A 1 234 GLN 234 257 257 GLN GLN A . n 
A 1 235 ARG 235 258 258 ARG ARG A . n 
A 1 236 ILE 236 259 259 ILE ILE A . n 
A 1 237 MET 237 260 260 MET MET A . n 
A 1 238 ASP 238 261 261 ASP ASP A . n 
A 1 239 GLU 239 262 262 GLU GLU A . n 
A 1 240 VAL 240 263 263 VAL VAL A . n 
A 1 241 THR 241 264 264 THR THR A . n 
A 1 242 VAL 242 265 265 VAL VAL A . n 
A 1 243 GLN 243 266 266 GLN GLN A . n 
A 1 244 VAL 244 267 267 VAL VAL A . n 
A 1 245 ASN 245 268 268 ASN ASN A . n 
A 1 246 LEU 246 269 269 LEU LEU A . n 
A 1 247 GLU 247 270 270 GLU GLU A . n 
A 1 248 ALA 248 271 271 ALA ALA A . n 
A 1 249 GLU 249 272 272 GLU GLU A . n 
A 1 250 ARG 250 273 273 ARG ARG A . n 
A 1 251 LEU 251 274 274 LEU LEU A . n 
A 1 252 ASN 252 275 275 ASN ASN A . n 
A 1 253 ARG 253 276 276 ARG ARG A . n 
A 1 254 ASP 254 277 277 ASP ASP A . n 
A 1 255 ALA 255 278 278 ALA ALA A . n 
A 1 256 ARG 256 279 279 ARG ARG A . n 
A 1 257 GLN 257 280 280 GLN GLN A . n 
A 1 258 ARG 258 281 281 ARG ARG A . n 
A 1 259 ILE 259 282 282 ILE ILE A . n 
A 1 260 LEU 260 283 283 LEU LEU A . n 
A 1 261 ALA 261 284 284 ALA ALA A . n 
A 1 262 SER 262 285 285 SER SER A . n 
A 1 263 GLY 263 286 286 GLY GLY A . n 
A 1 264 ALA 264 287 287 ALA ALA A . n 
A 1 265 SER 265 288 288 SER SER A . n 
A 1 266 GLU 266 289 289 GLU GLU A . n 
A 1 267 ILE 267 290 290 ILE ILE A . n 
A 1 268 HIS 268 291 291 HIS HIS A . n 
A 1 269 THR 269 292 292 THR THR A . n 
A 1 270 LEU 270 293 293 LEU LEU A . n 
A 1 271 SER 271 294 294 SER SER A . n 
A 1 272 PRO 272 295 295 PRO PRO A . n 
A 1 273 GLN 273 296 296 GLN GLN A . n 
A 1 274 GLN 274 297 297 GLN GLN A . n 
A 1 275 ARG 275 298 298 ARG ARG A . n 
A 1 276 ALA 276 299 299 ALA ALA A . n 
A 1 277 ASP 277 300 300 ASP ASP A . n 
A 1 278 TRP 278 301 301 TRP TRP A . n 
A 1 279 ARG 279 302 302 ARG ARG A . n 
A 1 280 GLN 280 303 303 GLN GLN A . n 
A 1 281 ALA 281 304 304 ALA ALA A . n 
A 1 282 MET 282 305 305 MET MET A . n 
A 1 283 GLN 283 306 306 GLN GLN A . n 
A 1 284 PRO 284 307 307 PRO PRO A . n 
A 1 285 VAL 285 308 308 VAL VAL A . n 
A 1 286 TRP 286 309 309 TRP TRP A . n 
A 1 287 GLN 287 310 310 GLN GLN A . n 
A 1 288 LYS 288 311 311 LYS LYS A . n 
A 1 289 PHE 289 312 312 PHE PHE A . n 
A 1 290 ARG 290 313 313 ARG ARG A . n 
A 1 291 GLY 291 314 314 GLY GLY A . n 
A 1 292 ASN 292 315 315 ASN ASN A . n 
A 1 293 VAL 293 316 316 VAL VAL A . n 
A 1 294 GLY 294 317 317 GLY GLY A . n 
A 1 295 ALA 295 318 318 ALA ALA A . n 
A 1 296 ASP 296 319 319 ASP ASP A . n 
A 1 297 LEU 297 320 320 LEU LEU A . n 
A 1 298 LEU 298 321 321 LEU LEU A . n 
A 1 299 GLN 299 322 322 GLN GLN A . n 
A 1 300 ALA 300 323 323 ALA ALA A . n 
A 1 301 ALA 301 324 324 ALA ALA A . n 
A 1 302 GLU 302 325 325 GLU GLU A . n 
A 1 303 ALA 303 326 326 ALA ALA A . n 
A 1 304 SER 304 327 327 SER SER A . n 
A 1 305 ASN 305 328 328 ASN ASN A . n 
A 1 306 ARG 306 329 329 ARG ARG A . n 
A 1 307 PRO 307 330 330 PRO PRO A . n 
A 1 308 ASP 308 331 ?   ?   ?   A . n 
B 1 1   ALA 1   24  ?   ?   ?   B . n 
B 1 2   GLN 2   25  ?   ?   ?   B . n 
B 1 3   PRO 3   26  26  PRO PRO B . n 
B 1 4   ILE 4   27  27  ILE ILE B . n 
B 1 5   VAL 5   28  28  VAL VAL B . n 
B 1 6   ILE 6   29  29  ILE ILE B . n 
B 1 7   LYS 7   30  30  LYS LYS B . n 
B 1 8   PHE 8   31  31  PHE PHE B . n 
B 1 9   SER 9   32  32  SER SER B . n 
B 1 10  HIS 10  33  33  HIS HIS B . n 
B 1 11  VAL 11  34  34  VAL VAL B . n 
B 1 12  VAL 12  35  35  VAL VAL B . n 
B 1 13  ALA 13  36  36  ALA ALA B . n 
B 1 14  GLU 14  37  37  GLU GLU B . n 
B 1 15  ASN 15  38  38  ASN ASN B . n 
B 1 16  THR 16  39  39  THR THR B . n 
B 1 17  PRO 17  40  40  PRO PRO B . n 
B 1 18  LYS 18  41  41  LYS LYS B . n 
B 1 19  GLY 19  42  42  GLY GLY B . n 
B 1 20  GLN 20  43  43  GLN GLN B . n 
B 1 21  GLY 21  44  44  GLY GLY B . n 
B 1 22  ALA 22  45  45  ALA ALA B . n 
B 1 23  LEU 23  46  46  LEU LEU B . n 
B 1 24  LEU 24  47  47  LEU LEU B . n 
B 1 25  PHE 25  48  48  PHE PHE B . n 
B 1 26  LYS 26  49  49  LYS LYS B . n 
B 1 27  LYS 27  50  50  LYS LYS B . n 
B 1 28  LEU 28  51  51  LEU LEU B . n 
B 1 29  VAL 29  52  52  VAL VAL B . n 
B 1 30  GLU 30  53  53  GLU GLU B . n 
B 1 31  GLN 31  54  54  GLN GLN B . n 
B 1 32  ARG 32  55  55  ARG ARG B . n 
B 1 33  LEU 33  56  56  LEU LEU B . n 
B 1 34  GLY 34  57  57  GLY GLY B . n 
B 1 35  GLY 35  58  58  GLY GLY B . n 
B 1 36  ARG 36  59  59  ARG ARG B . n 
B 1 37  VAL 37  60  60  VAL VAL B . n 
B 1 38  GLU 38  61  61  GLU GLU B . n 
B 1 39  VAL 39  62  62  VAL VAL B . n 
B 1 40  ASP 40  63  63  ASP ASP B . n 
B 1 41  VAL 41  64  64  VAL VAL B . n 
B 1 42  TYR 42  65  65  TYR TYR B . n 
B 1 43  PRO 43  66  66  PRO PRO B . n 
B 1 44  ASN 44  67  67  ASN ASN B . n 
B 1 45  SER 45  68  68  SER SER B . n 
B 1 46  SER 46  69  69  SER SER B . n 
B 1 47  LEU 47  70  70  LEU LEU B . n 
B 1 48  PHE 48  71  71  PHE PHE B . n 
B 1 49  GLY 49  72  72  GLY GLY B . n 
B 1 50  ASP 50  73  73  ASP ASP B . n 
B 1 51  GLY 51  74  74  GLY GLY B . n 
B 1 52  LYS 52  75  75  LYS LYS B . n 
B 1 53  GLU 53  76  76  GLU GLU B . n 
B 1 54  MET 54  77  77  MET MET B . n 
B 1 55  GLU 55  78  78  GLU GLU B . n 
B 1 56  ALA 56  79  79  ALA ALA B . n 
B 1 57  LEU 57  80  80  LEU LEU B . n 
B 1 58  LEU 58  81  81  LEU LEU B . n 
B 1 59  LEU 59  82  82  LEU LEU B . n 
B 1 60  GLY 60  83  83  GLY GLY B . n 
B 1 61  ASP 61  84  84  ASP ASP B . n 
B 1 62  VAL 62  85  85  VAL VAL B . n 
B 1 63  GLN 63  86  86  GLN GLN B . n 
B 1 64  MET 64  87  87  MET MET B . n 
B 1 65  LEU 65  88  88  LEU LEU B . n 
B 1 66  ALA 66  89  89  ALA ALA B . n 
B 1 67  PRO 67  90  90  PRO PRO B . n 
B 1 68  SER 68  91  91  SER SER B . n 
B 1 69  LEU 69  92  92  LEU LEU B . n 
B 1 70  ALA 70  93  93  ALA ALA B . n 
B 1 71  LYS 71  94  94  LYS LYS B . n 
B 1 72  PHE 72  95  95  PHE PHE B . n 
B 1 73  GLU 73  96  96  GLU GLU B . n 
B 1 74  GLN 74  97  97  GLN GLN B . n 
B 1 75  TYR 75  98  98  TYR TYR B . n 
B 1 76  THR 76  99  99  THR THR B . n 
B 1 77  ARG 77  100 100 ARG ARG B . n 
B 1 78  LYS 78  101 101 LYS LYS B . n 
B 1 79  VAL 79  102 102 VAL VAL B . n 
B 1 80  GLN 80  103 103 GLN GLN B . n 
B 1 81  ILE 81  104 104 ILE ILE B . n 
B 1 82  PHE 82  105 105 PHE PHE B . n 
B 1 83  ASP 83  106 106 ASP ASP B . n 
B 1 84  LEU 84  107 107 LEU LEU B . n 
B 1 85  PRO 85  108 108 PRO PRO B . n 
B 1 86  PHE 86  109 109 PHE PHE B . n 
B 1 87  LEU 87  110 110 LEU LEU B . n 
B 1 88  PHE 88  111 111 PHE PHE B . n 
B 1 89  ASP 89  112 112 ASP ASP B . n 
B 1 90  ASP 90  113 113 ASP ASP B . n 
B 1 91  ILE 91  114 114 ILE ILE B . n 
B 1 92  GLN 92  115 115 GLN GLN B . n 
B 1 93  ALA 93  116 116 ALA ALA B . n 
B 1 94  VAL 94  117 117 VAL VAL B . n 
B 1 95  ASP 95  118 118 ASP ASP B . n 
B 1 96  ARG 96  119 119 ARG ARG B . n 
B 1 97  PHE 97  120 120 PHE PHE B . n 
B 1 98  GLN 98  121 121 GLN GLN B . n 
B 1 99  ARG 99  122 122 ARG ARG B . n 
B 1 100 SER 100 123 123 SER SER B . n 
B 1 101 PRO 101 124 124 PRO PRO B . n 
B 1 102 GLN 102 125 125 GLN GLN B . n 
B 1 103 GLY 103 126 126 GLY GLY B . n 
B 1 104 ARG 104 127 127 ARG ARG B . n 
B 1 105 ALA 105 128 128 ALA ALA B . n 
B 1 106 LEU 106 129 129 LEU LEU B . n 
B 1 107 LEU 107 130 130 LEU LEU B . n 
B 1 108 THR 108 131 131 THR THR B . n 
B 1 109 SER 109 132 132 SER SER B . n 
B 1 110 MET 110 133 133 MET MET B . n 
B 1 111 GLN 111 134 134 GLN GLN B . n 
B 1 112 GLY 112 135 135 GLY GLY B . n 
B 1 113 LYS 113 136 136 LYS LYS B . n 
B 1 114 GLY 114 137 137 GLY GLY B . n 
B 1 115 ILE 115 138 138 ILE ILE B . n 
B 1 116 LEU 116 139 139 LEU LEU B . n 
B 1 117 GLY 117 140 140 GLY GLY B . n 
B 1 118 LEU 118 141 141 LEU LEU B . n 
B 1 119 ALA 119 142 142 ALA ALA B . n 
B 1 120 TYR 120 143 143 TYR TYR B . n 
B 1 121 TRP 121 144 144 TRP TRP B . n 
B 1 122 HIS 122 145 145 HIS HIS B . n 
B 1 123 ASN 123 146 146 ASN ASN B . n 
B 1 124 GLY 124 147 147 GLY GLY B . n 
B 1 125 MET 125 148 148 MET MET B . n 
B 1 126 LYS 126 149 149 LYS LYS B . n 
B 1 127 GLN 127 150 150 GLN GLN B . n 
B 1 128 LEU 128 151 151 LEU LEU B . n 
B 1 129 SER 129 152 152 SER SER B . n 
B 1 130 ALA 130 153 153 ALA ALA B . n 
B 1 131 ASN 131 154 154 ASN ASN B . n 
B 1 132 ARG 132 155 155 ARG ARG B . n 
B 1 133 PRO 133 156 156 PRO PRO B . n 
B 1 134 LEU 134 157 157 LEU LEU B . n 
B 1 135 LEU 135 158 158 LEU LEU B . n 
B 1 136 GLU 136 159 159 GLU GLU B . n 
B 1 137 PRO 137 160 160 PRO PRO B . n 
B 1 138 GLU 138 161 161 GLU GLU B . n 
B 1 139 ASP 139 162 162 ASP ASP B . n 
B 1 140 ALA 140 163 163 ALA ALA B . n 
B 1 141 ARG 141 164 164 ARG ARG B . n 
B 1 142 GLY 142 165 165 GLY GLY B . n 
B 1 143 LEU 143 166 166 LEU LEU B . n 
B 1 144 LYS 144 167 167 LYS LYS B . n 
B 1 145 PHE 145 168 168 PHE PHE B . n 
B 1 146 ARG 146 169 169 ARG ARG B . n 
B 1 147 VAL 147 170 170 VAL VAL B . n 
B 1 148 GLN 148 171 171 GLN GLN B . n 
B 1 149 ALA 149 172 172 ALA ALA B . n 
B 1 150 SER 150 173 173 SER SER B . n 
B 1 151 ASP 151 174 174 ASP ASP B . n 
B 1 152 VAL 152 175 175 VAL VAL B . n 
B 1 153 LEU 153 176 176 LEU LEU B . n 
B 1 154 ASN 154 177 177 ASN ASN B . n 
B 1 155 GLU 155 178 178 GLU GLU B . n 
B 1 156 GLN 156 179 179 GLN GLN B . n 
B 1 157 PHE 157 180 180 PHE PHE B . n 
B 1 158 ARG 158 181 181 ARG ARG B . n 
B 1 159 GLN 159 182 182 GLN GLN B . n 
B 1 160 LEU 160 183 183 LEU LEU B . n 
B 1 161 ARG 161 184 184 ARG ARG B . n 
B 1 162 ALA 162 185 185 ALA ALA B . n 
B 1 163 ILE 163 186 186 ILE ILE B . n 
B 1 164 SER 164 187 187 SER SER B . n 
B 1 165 ARG 165 188 188 ARG ARG B . n 
B 1 166 LYS 166 189 189 LYS LYS B . n 
B 1 167 MET 167 190 190 MET MET B . n 
B 1 168 SER 168 191 191 SER SER B . n 
B 1 169 PHE 169 192 192 PHE PHE B . n 
B 1 170 ALA 170 193 193 ALA ALA B . n 
B 1 171 GLU 171 194 194 GLU GLU B . n 
B 1 172 VAL 172 195 195 VAL VAL B . n 
B 1 173 TYR 173 196 196 TYR TYR B . n 
B 1 174 GLN 174 197 197 GLN GLN B . n 
B 1 175 GLY 175 198 198 GLY GLY B . n 
B 1 176 LEU 176 199 199 LEU LEU B . n 
B 1 177 GLN 177 200 200 GLN GLN B . n 
B 1 178 THR 178 201 201 THR THR B . n 
B 1 179 GLY 179 202 202 GLY GLY B . n 
B 1 180 VAL 180 203 203 VAL VAL B . n 
B 1 181 VAL 181 204 204 VAL VAL B . n 
B 1 182 ASN 182 205 205 ASN ASN B . n 
B 1 183 GLY 183 206 206 GLY GLY B . n 
B 1 184 THR 184 207 207 THR THR B . n 
B 1 185 GLU 185 208 208 GLU GLU B . n 
B 1 186 ASN 186 209 209 ASN ASN B . n 
B 1 187 THR 187 210 210 THR THR B . n 
B 1 188 TRP 188 211 211 TRP TRP B . n 
B 1 189 SER 189 212 212 SER SER B . n 
B 1 190 ASN 190 213 213 ASN ASN B . n 
B 1 191 TYR 191 214 214 TYR TYR B . n 
B 1 192 GLU 192 215 215 GLU GLU B . n 
B 1 193 SER 193 216 216 SER SER B . n 
B 1 194 GLN 194 217 217 GLN GLN B . n 
B 1 195 LYS 195 218 218 LYS LYS B . n 
B 1 196 VAL 196 219 219 VAL VAL B . n 
B 1 197 ASN 197 220 220 ASN ASN B . n 
B 1 198 GLU 198 221 221 GLU GLU B . n 
B 1 199 VAL 199 222 222 VAL VAL B . n 
B 1 200 GLN 200 223 223 GLN GLN B . n 
B 1 201 LYS 201 224 224 LYS LYS B . n 
B 1 202 TYR 202 225 225 TYR TYR B . n 
B 1 203 PHE 203 226 226 PHE PHE B . n 
B 1 204 THR 204 227 227 THR THR B . n 
B 1 205 GLU 205 228 228 GLU GLU B . n 
B 1 206 SER 206 229 229 SER SER B . n 
B 1 207 ASN 207 230 230 ASN ASN B . n 
B 1 208 HIS 208 231 231 HIS HIS B . n 
B 1 209 GLY 209 232 232 GLY GLY B . n 
B 1 210 LEU 210 233 233 LEU LEU B . n 
B 1 211 VAL 211 234 234 VAL VAL B . n 
B 1 212 ASP 212 235 235 ASP ASP B . n 
B 1 213 TYR 213 236 236 TYR TYR B . n 
B 1 214 MET 214 237 237 MET MET B . n 
B 1 215 VAL 215 238 238 VAL VAL B . n 
B 1 216 ILE 216 239 239 ILE ILE B . n 
B 1 217 THR 217 240 240 THR THR B . n 
B 1 218 ASN 218 241 241 ASN ASN B . n 
B 1 219 ALA 219 242 242 ALA ALA B . n 
B 1 220 LYS 220 243 243 LYS LYS B . n 
B 1 221 PHE 221 244 244 PHE PHE B . n 
B 1 222 TRP 222 245 245 TRP TRP B . n 
B 1 223 ASN 223 246 246 ASN ASN B . n 
B 1 224 GLY 224 247 247 GLY GLY B . n 
B 1 225 LEU 225 248 248 LEU LEU B . n 
B 1 226 PRO 226 249 249 PRO PRO B . n 
B 1 227 ALA 227 250 250 ALA ALA B . n 
B 1 228 ASP 228 251 251 ASP ASP B . n 
B 1 229 ILE 229 252 252 ILE ILE B . n 
B 1 230 ARG 230 253 253 ARG ARG B . n 
B 1 231 GLU 231 254 254 GLU GLU B . n 
B 1 232 GLU 232 255 255 GLU GLU B . n 
B 1 233 LEU 233 256 256 LEU LEU B . n 
B 1 234 GLN 234 257 257 GLN GLN B . n 
B 1 235 ARG 235 258 258 ARG ARG B . n 
B 1 236 ILE 236 259 259 ILE ILE B . n 
B 1 237 MET 237 260 260 MET MET B . n 
B 1 238 ASP 238 261 261 ASP ASP B . n 
B 1 239 GLU 239 262 262 GLU GLU B . n 
B 1 240 VAL 240 263 263 VAL VAL B . n 
B 1 241 THR 241 264 264 THR THR B . n 
B 1 242 VAL 242 265 265 VAL VAL B . n 
B 1 243 GLN 243 266 266 GLN GLN B . n 
B 1 244 VAL 244 267 267 VAL VAL B . n 
B 1 245 ASN 245 268 268 ASN ASN B . n 
B 1 246 LEU 246 269 269 LEU LEU B . n 
B 1 247 GLU 247 270 270 GLU GLU B . n 
B 1 248 ALA 248 271 271 ALA ALA B . n 
B 1 249 GLU 249 272 272 GLU GLU B . n 
B 1 250 ARG 250 273 273 ARG ARG B . n 
B 1 251 LEU 251 274 274 LEU LEU B . n 
B 1 252 ASN 252 275 275 ASN ASN B . n 
B 1 253 ARG 253 276 276 ARG ARG B . n 
B 1 254 ASP 254 277 277 ASP ASP B . n 
B 1 255 ALA 255 278 278 ALA ALA B . n 
B 1 256 ARG 256 279 279 ARG ARG B . n 
B 1 257 GLN 257 280 280 GLN GLN B . n 
B 1 258 ARG 258 281 281 ARG ARG B . n 
B 1 259 ILE 259 282 282 ILE ILE B . n 
B 1 260 LEU 260 283 283 LEU LEU B . n 
B 1 261 ALA 261 284 284 ALA ALA B . n 
B 1 262 SER 262 285 285 SER SER B . n 
B 1 263 GLY 263 286 286 GLY GLY B . n 
B 1 264 ALA 264 287 287 ALA ALA B . n 
B 1 265 SER 265 288 288 SER SER B . n 
B 1 266 GLU 266 289 289 GLU GLU B . n 
B 1 267 ILE 267 290 290 ILE ILE B . n 
B 1 268 HIS 268 291 291 HIS HIS B . n 
B 1 269 THR 269 292 292 THR THR B . n 
B 1 270 LEU 270 293 293 LEU LEU B . n 
B 1 271 SER 271 294 294 SER SER B . n 
B 1 272 PRO 272 295 295 PRO PRO B . n 
B 1 273 GLN 273 296 296 GLN GLN B . n 
B 1 274 GLN 274 297 297 GLN GLN B . n 
B 1 275 ARG 275 298 298 ARG ARG B . n 
B 1 276 ALA 276 299 299 ALA ALA B . n 
B 1 277 ASP 277 300 300 ASP ASP B . n 
B 1 278 TRP 278 301 301 TRP TRP B . n 
B 1 279 ARG 279 302 302 ARG ARG B . n 
B 1 280 GLN 280 303 303 GLN GLN B . n 
B 1 281 ALA 281 304 304 ALA ALA B . n 
B 1 282 MET 282 305 305 MET MET B . n 
B 1 283 GLN 283 306 306 GLN GLN B . n 
B 1 284 PRO 284 307 307 PRO PRO B . n 
B 1 285 VAL 285 308 308 VAL VAL B . n 
B 1 286 TRP 286 309 309 TRP TRP B . n 
B 1 287 GLN 287 310 310 GLN GLN B . n 
B 1 288 LYS 288 311 311 LYS LYS B . n 
B 1 289 PHE 289 312 312 PHE PHE B . n 
B 1 290 ARG 290 313 313 ARG ARG B . n 
B 1 291 GLY 291 314 314 GLY GLY B . n 
B 1 292 ASN 292 315 315 ASN ASN B . n 
B 1 293 VAL 293 316 316 VAL VAL B . n 
B 1 294 GLY 294 317 317 GLY GLY B . n 
B 1 295 ALA 295 318 318 ALA ALA B . n 
B 1 296 ASP 296 319 319 ASP ASP B . n 
B 1 297 LEU 297 320 320 LEU LEU B . n 
B 1 298 LEU 298 321 321 LEU LEU B . n 
B 1 299 GLN 299 322 322 GLN GLN B . n 
B 1 300 ALA 300 323 323 ALA ALA B . n 
B 1 301 ALA 301 324 324 ALA ALA B . n 
B 1 302 GLU 302 325 325 GLU GLU B . n 
B 1 303 ALA 303 326 326 ALA ALA B . n 
B 1 304 SER 304 327 327 SER SER B . n 
B 1 305 ASN 305 328 328 ASN ASN B . n 
B 1 306 ARG 306 329 329 ARG ARG B . n 
B 1 307 PRO 307 330 330 PRO PRO B . n 
B 1 308 ASP 308 331 ?   ?   ?   B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        SIN 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   SIN 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 SIN 1   401 401 SIN SIN A . 
D 2 SIN 1   401 401 SIN SIN B . 
E 3 HOH 1   501 207 HOH HOH A . 
E 3 HOH 2   502 181 HOH HOH A . 
E 3 HOH 3   503 259 HOH HOH A . 
E 3 HOH 4   504 39  HOH HOH A . 
E 3 HOH 5   505 245 HOH HOH A . 
E 3 HOH 6   506 123 HOH HOH A . 
E 3 HOH 7   507 120 HOH HOH A . 
E 3 HOH 8   508 225 HOH HOH A . 
E 3 HOH 9   509 228 HOH HOH A . 
E 3 HOH 10  510 128 HOH HOH A . 
E 3 HOH 11  511 223 HOH HOH A . 
E 3 HOH 12  512 28  HOH HOH A . 
E 3 HOH 13  513 54  HOH HOH A . 
E 3 HOH 14  514 327 HOH HOH A . 
E 3 HOH 15  515 81  HOH HOH A . 
E 3 HOH 16  516 143 HOH HOH A . 
E 3 HOH 17  517 175 HOH HOH A . 
E 3 HOH 18  518 208 HOH HOH A . 
E 3 HOH 19  519 147 HOH HOH A . 
E 3 HOH 20  520 192 HOH HOH A . 
E 3 HOH 21  521 304 HOH HOH A . 
E 3 HOH 22  522 290 HOH HOH A . 
E 3 HOH 23  523 227 HOH HOH A . 
E 3 HOH 24  524 184 HOH HOH A . 
E 3 HOH 25  525 72  HOH HOH A . 
E 3 HOH 26  526 306 HOH HOH A . 
E 3 HOH 27  527 68  HOH HOH A . 
E 3 HOH 28  528 129 HOH HOH A . 
E 3 HOH 29  529 201 HOH HOH A . 
E 3 HOH 30  530 164 HOH HOH A . 
E 3 HOH 31  531 233 HOH HOH A . 
E 3 HOH 32  532 253 HOH HOH A . 
E 3 HOH 33  533 18  HOH HOH A . 
E 3 HOH 34  534 273 HOH HOH A . 
E 3 HOH 35  535 261 HOH HOH A . 
E 3 HOH 36  536 33  HOH HOH A . 
E 3 HOH 37  537 249 HOH HOH A . 
E 3 HOH 38  538 3   HOH HOH A . 
E 3 HOH 39  539 98  HOH HOH A . 
E 3 HOH 40  540 330 HOH HOH A . 
E 3 HOH 41  541 53  HOH HOH A . 
E 3 HOH 42  542 23  HOH HOH A . 
E 3 HOH 43  543 248 HOH HOH A . 
E 3 HOH 44  544 301 HOH HOH A . 
E 3 HOH 45  545 9   HOH HOH A . 
E 3 HOH 46  546 96  HOH HOH A . 
E 3 HOH 47  547 25  HOH HOH A . 
E 3 HOH 48  548 115 HOH HOH A . 
E 3 HOH 49  549 133 HOH HOH A . 
E 3 HOH 50  550 60  HOH HOH A . 
E 3 HOH 51  551 220 HOH HOH A . 
E 3 HOH 52  552 108 HOH HOH A . 
E 3 HOH 53  553 27  HOH HOH A . 
E 3 HOH 54  554 234 HOH HOH A . 
E 3 HOH 55  555 135 HOH HOH A . 
E 3 HOH 56  556 94  HOH HOH A . 
E 3 HOH 57  557 17  HOH HOH A . 
E 3 HOH 58  558 167 HOH HOH A . 
E 3 HOH 59  559 63  HOH HOH A . 
E 3 HOH 60  560 264 HOH HOH A . 
E 3 HOH 61  561 283 HOH HOH A . 
E 3 HOH 62  562 191 HOH HOH A . 
E 3 HOH 63  563 82  HOH HOH A . 
E 3 HOH 64  564 70  HOH HOH A . 
E 3 HOH 65  565 203 HOH HOH A . 
E 3 HOH 66  566 111 HOH HOH A . 
E 3 HOH 67  567 212 HOH HOH A . 
E 3 HOH 68  568 8   HOH HOH A . 
E 3 HOH 69  569 162 HOH HOH A . 
E 3 HOH 70  570 182 HOH HOH A . 
E 3 HOH 71  571 242 HOH HOH A . 
E 3 HOH 72  572 77  HOH HOH A . 
E 3 HOH 73  573 206 HOH HOH A . 
E 3 HOH 74  574 36  HOH HOH A . 
E 3 HOH 75  575 41  HOH HOH A . 
E 3 HOH 76  576 204 HOH HOH A . 
E 3 HOH 77  577 278 HOH HOH A . 
E 3 HOH 78  578 84  HOH HOH A . 
E 3 HOH 79  579 190 HOH HOH A . 
E 3 HOH 80  580 130 HOH HOH A . 
E 3 HOH 81  581 26  HOH HOH A . 
E 3 HOH 82  582 76  HOH HOH A . 
E 3 HOH 83  583 235 HOH HOH A . 
E 3 HOH 84  584 91  HOH HOH A . 
E 3 HOH 85  585 186 HOH HOH A . 
E 3 HOH 86  586 263 HOH HOH A . 
E 3 HOH 87  587 59  HOH HOH A . 
E 3 HOH 88  588 194 HOH HOH A . 
E 3 HOH 89  589 299 HOH HOH A . 
E 3 HOH 90  590 34  HOH HOH A . 
E 3 HOH 91  591 171 HOH HOH A . 
E 3 HOH 92  592 188 HOH HOH A . 
E 3 HOH 93  593 183 HOH HOH A . 
E 3 HOH 94  594 112 HOH HOH A . 
E 3 HOH 95  595 170 HOH HOH A . 
E 3 HOH 96  596 31  HOH HOH A . 
E 3 HOH 97  597 10  HOH HOH A . 
E 3 HOH 98  598 12  HOH HOH A . 
E 3 HOH 99  599 105 HOH HOH A . 
E 3 HOH 100 600 307 HOH HOH A . 
E 3 HOH 101 601 231 HOH HOH A . 
E 3 HOH 102 602 271 HOH HOH A . 
E 3 HOH 103 603 21  HOH HOH A . 
E 3 HOH 104 604 279 HOH HOH A . 
E 3 HOH 105 605 177 HOH HOH A . 
E 3 HOH 106 606 187 HOH HOH A . 
E 3 HOH 107 607 52  HOH HOH A . 
E 3 HOH 108 608 155 HOH HOH A . 
E 3 HOH 109 609 229 HOH HOH A . 
E 3 HOH 110 610 276 HOH HOH A . 
E 3 HOH 111 611 153 HOH HOH A . 
E 3 HOH 112 612 217 HOH HOH A . 
E 3 HOH 113 613 45  HOH HOH A . 
E 3 HOH 114 614 308 HOH HOH A . 
E 3 HOH 115 615 160 HOH HOH A . 
E 3 HOH 116 616 323 HOH HOH A . 
E 3 HOH 117 617 101 HOH HOH A . 
E 3 HOH 118 618 329 HOH HOH A . 
E 3 HOH 119 619 43  HOH HOH A . 
E 3 HOH 120 620 83  HOH HOH A . 
E 3 HOH 121 621 214 HOH HOH A . 
E 3 HOH 122 622 7   HOH HOH A . 
E 3 HOH 123 623 254 HOH HOH A . 
E 3 HOH 124 624 262 HOH HOH A . 
E 3 HOH 125 625 213 HOH HOH A . 
E 3 HOH 126 626 30  HOH HOH A . 
E 3 HOH 127 627 325 HOH HOH A . 
E 3 HOH 128 628 38  HOH HOH A . 
E 3 HOH 129 629 302 HOH HOH A . 
E 3 HOH 130 630 314 HOH HOH A . 
E 3 HOH 131 631 168 HOH HOH A . 
E 3 HOH 132 632 125 HOH HOH A . 
E 3 HOH 133 633 65  HOH HOH A . 
E 3 HOH 134 634 24  HOH HOH A . 
E 3 HOH 135 635 161 HOH HOH A . 
E 3 HOH 136 636 103 HOH HOH A . 
E 3 HOH 137 637 22  HOH HOH A . 
E 3 HOH 138 638 100 HOH HOH A . 
E 3 HOH 139 639 198 HOH HOH A . 
E 3 HOH 140 640 199 HOH HOH A . 
E 3 HOH 141 641 5   HOH HOH A . 
E 3 HOH 142 642 106 HOH HOH A . 
E 3 HOH 143 643 172 HOH HOH A . 
E 3 HOH 144 644 78  HOH HOH A . 
E 3 HOH 145 645 284 HOH HOH A . 
E 3 HOH 146 646 107 HOH HOH A . 
E 3 HOH 147 647 13  HOH HOH A . 
E 3 HOH 148 648 156 HOH HOH A . 
E 3 HOH 149 649 251 HOH HOH A . 
E 3 HOH 150 650 145 HOH HOH A . 
E 3 HOH 151 651 268 HOH HOH A . 
E 3 HOH 152 652 222 HOH HOH A . 
E 3 HOH 153 653 196 HOH HOH A . 
E 3 HOH 154 654 310 HOH HOH A . 
E 3 HOH 155 655 211 HOH HOH A . 
E 3 HOH 156 656 166 HOH HOH A . 
E 3 HOH 157 657 309 HOH HOH A . 
E 3 HOH 158 658 312 HOH HOH A . 
E 3 HOH 159 659 221 HOH HOH A . 
E 3 HOH 160 660 257 HOH HOH A . 
E 3 HOH 161 661 315 HOH HOH A . 
E 3 HOH 162 662 140 HOH HOH A . 
E 3 HOH 163 663 215 HOH HOH A . 
E 3 HOH 164 664 287 HOH HOH A . 
E 3 HOH 165 665 281 HOH HOH A . 
E 3 HOH 166 666 317 HOH HOH A . 
E 3 HOH 167 667 298 HOH HOH A . 
E 3 HOH 168 668 321 HOH HOH A . 
E 3 HOH 169 669 240 HOH HOH A . 
E 3 HOH 170 670 296 HOH HOH A . 
E 3 HOH 171 671 313 HOH HOH A . 
E 3 HOH 172 672 139 HOH HOH A . 
E 3 HOH 173 673 47  HOH HOH A . 
F 3 HOH 1   501 197 HOH HOH B . 
F 3 HOH 2   502 232 HOH HOH B . 
F 3 HOH 3   503 19  HOH HOH B . 
F 3 HOH 4   504 157 HOH HOH B . 
F 3 HOH 5   505 243 HOH HOH B . 
F 3 HOH 6   506 266 HOH HOH B . 
F 3 HOH 7   507 200 HOH HOH B . 
F 3 HOH 8   508 146 HOH HOH B . 
F 3 HOH 9   509 219 HOH HOH B . 
F 3 HOH 10  510 305 HOH HOH B . 
F 3 HOH 11  511 44  HOH HOH B . 
F 3 HOH 12  512 48  HOH HOH B . 
F 3 HOH 13  513 185 HOH HOH B . 
F 3 HOH 14  514 42  HOH HOH B . 
F 3 HOH 15  515 55  HOH HOH B . 
F 3 HOH 16  516 141 HOH HOH B . 
F 3 HOH 17  517 289 HOH HOH B . 
F 3 HOH 18  518 40  HOH HOH B . 
F 3 HOH 19  519 224 HOH HOH B . 
F 3 HOH 20  520 236 HOH HOH B . 
F 3 HOH 21  521 293 HOH HOH B . 
F 3 HOH 22  522 297 HOH HOH B . 
F 3 HOH 23  523 270 HOH HOH B . 
F 3 HOH 24  524 88  HOH HOH B . 
F 3 HOH 25  525 179 HOH HOH B . 
F 3 HOH 26  526 255 HOH HOH B . 
F 3 HOH 27  527 176 HOH HOH B . 
F 3 HOH 28  528 326 HOH HOH B . 
F 3 HOH 29  529 119 HOH HOH B . 
F 3 HOH 30  530 209 HOH HOH B . 
F 3 HOH 31  531 37  HOH HOH B . 
F 3 HOH 32  532 14  HOH HOH B . 
F 3 HOH 33  533 218 HOH HOH B . 
F 3 HOH 34  534 144 HOH HOH B . 
F 3 HOH 35  535 66  HOH HOH B . 
F 3 HOH 36  536 56  HOH HOH B . 
F 3 HOH 37  537 216 HOH HOH B . 
F 3 HOH 38  538 86  HOH HOH B . 
F 3 HOH 39  539 180 HOH HOH B . 
F 3 HOH 40  540 189 HOH HOH B . 
F 3 HOH 41  541 277 HOH HOH B . 
F 3 HOH 42  542 292 HOH HOH B . 
F 3 HOH 43  543 202 HOH HOH B . 
F 3 HOH 44  544 51  HOH HOH B . 
F 3 HOH 45  545 174 HOH HOH B . 
F 3 HOH 46  546 50  HOH HOH B . 
F 3 HOH 47  547 159 HOH HOH B . 
F 3 HOH 48  548 117 HOH HOH B . 
F 3 HOH 49  549 246 HOH HOH B . 
F 3 HOH 50  550 109 HOH HOH B . 
F 3 HOH 51  551 85  HOH HOH B . 
F 3 HOH 52  552 32  HOH HOH B . 
F 3 HOH 53  553 69  HOH HOH B . 
F 3 HOH 54  554 136 HOH HOH B . 
F 3 HOH 55  555 260 HOH HOH B . 
F 3 HOH 56  556 124 HOH HOH B . 
F 3 HOH 57  557 158 HOH HOH B . 
F 3 HOH 58  558 252 HOH HOH B . 
F 3 HOH 59  559 104 HOH HOH B . 
F 3 HOH 60  560 20  HOH HOH B . 
F 3 HOH 61  561 122 HOH HOH B . 
F 3 HOH 62  562 272 HOH HOH B . 
F 3 HOH 63  563 113 HOH HOH B . 
F 3 HOH 64  564 92  HOH HOH B . 
F 3 HOH 65  565 169 HOH HOH B . 
F 3 HOH 66  566 280 HOH HOH B . 
F 3 HOH 67  567 178 HOH HOH B . 
F 3 HOH 68  568 4   HOH HOH B . 
F 3 HOH 69  569 286 HOH HOH B . 
F 3 HOH 70  570 93  HOH HOH B . 
F 3 HOH 71  571 89  HOH HOH B . 
F 3 HOH 72  572 324 HOH HOH B . 
F 3 HOH 73  573 151 HOH HOH B . 
F 3 HOH 74  574 300 HOH HOH B . 
F 3 HOH 75  575 288 HOH HOH B . 
F 3 HOH 76  576 99  HOH HOH B . 
F 3 HOH 77  577 90  HOH HOH B . 
F 3 HOH 78  578 58  HOH HOH B . 
F 3 HOH 79  579 126 HOH HOH B . 
F 3 HOH 80  580 195 HOH HOH B . 
F 3 HOH 81  581 29  HOH HOH B . 
F 3 HOH 82  582 49  HOH HOH B . 
F 3 HOH 83  583 149 HOH HOH B . 
F 3 HOH 84  584 154 HOH HOH B . 
F 3 HOH 85  585 256 HOH HOH B . 
F 3 HOH 86  586 131 HOH HOH B . 
F 3 HOH 87  587 132 HOH HOH B . 
F 3 HOH 88  588 87  HOH HOH B . 
F 3 HOH 89  589 116 HOH HOH B . 
F 3 HOH 90  590 16  HOH HOH B . 
F 3 HOH 91  591 163 HOH HOH B . 
F 3 HOH 92  592 142 HOH HOH B . 
F 3 HOH 93  593 15  HOH HOH B . 
F 3 HOH 94  594 11  HOH HOH B . 
F 3 HOH 95  595 311 HOH HOH B . 
F 3 HOH 96  596 75  HOH HOH B . 
F 3 HOH 97  597 64  HOH HOH B . 
F 3 HOH 98  598 150 HOH HOH B . 
F 3 HOH 99  599 95  HOH HOH B . 
F 3 HOH 100 600 74  HOH HOH B . 
F 3 HOH 101 601 127 HOH HOH B . 
F 3 HOH 102 602 57  HOH HOH B . 
F 3 HOH 103 603 238 HOH HOH B . 
F 3 HOH 104 604 237 HOH HOH B . 
F 3 HOH 105 605 148 HOH HOH B . 
F 3 HOH 106 606 61  HOH HOH B . 
F 3 HOH 107 607 294 HOH HOH B . 
F 3 HOH 108 608 247 HOH HOH B . 
F 3 HOH 109 609 274 HOH HOH B . 
F 3 HOH 110 610 73  HOH HOH B . 
F 3 HOH 111 611 35  HOH HOH B . 
F 3 HOH 112 612 67  HOH HOH B . 
F 3 HOH 113 613 269 HOH HOH B . 
F 3 HOH 114 614 97  HOH HOH B . 
F 3 HOH 115 615 165 HOH HOH B . 
F 3 HOH 116 616 193 HOH HOH B . 
F 3 HOH 117 617 118 HOH HOH B . 
F 3 HOH 118 618 173 HOH HOH B . 
F 3 HOH 119 619 137 HOH HOH B . 
F 3 HOH 120 620 226 HOH HOH B . 
F 3 HOH 121 621 62  HOH HOH B . 
F 3 HOH 122 622 265 HOH HOH B . 
F 3 HOH 123 623 6   HOH HOH B . 
F 3 HOH 124 624 114 HOH HOH B . 
F 3 HOH 125 625 80  HOH HOH B . 
F 3 HOH 126 626 250 HOH HOH B . 
F 3 HOH 127 627 285 HOH HOH B . 
F 3 HOH 128 628 205 HOH HOH B . 
F 3 HOH 129 629 267 HOH HOH B . 
F 3 HOH 130 630 328 HOH HOH B . 
F 3 HOH 131 631 134 HOH HOH B . 
F 3 HOH 132 632 230 HOH HOH B . 
F 3 HOH 133 633 319 HOH HOH B . 
F 3 HOH 134 634 303 HOH HOH B . 
F 3 HOH 135 635 316 HOH HOH B . 
F 3 HOH 136 636 138 HOH HOH B . 
F 3 HOH 137 637 239 HOH HOH B . 
F 3 HOH 138 638 79  HOH HOH B . 
F 3 HOH 139 639 320 HOH HOH B . 
F 3 HOH 140 640 102 HOH HOH B . 
F 3 HOH 141 641 244 HOH HOH B . 
F 3 HOH 142 642 291 HOH HOH B . 
F 3 HOH 143 643 241 HOH HOH B . 
F 3 HOH 144 644 318 HOH HOH B . 
F 3 HOH 145 645 295 HOH HOH B . 
F 3 HOH 146 646 282 HOH HOH B . 
F 3 HOH 147 647 322 HOH HOH B . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement     ? ? ? ? ? ? ? ? ? ? ? REFMAC  ? ? ? 5.8.0419 1 
? 'data scaling' ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .        2 
? phasing        ? ? ? ? ? ? ? ? ? ? ? MOLREP  ? ? ? .        3 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9HT4 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     33.957 
_cell.length_a_esd                 ? 
_cell.length_b                     118.525 
_cell.length_b_esd                 ? 
_cell.length_c                     167.210 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9HT4 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9HT4 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.41 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          48.92 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
'JCSG-plus HT-96 D12: 0.04 M Potassium phosphate monobasic, 16 % w/v PEG 8000, 20 % v/v Glycerol' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 XE 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-03-21 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.9763 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'DIAMOND BEAMLINE I03' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.9763 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   I03 
_diffrn_source.pdbx_synchrotron_site       Diamond 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9HT4 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.75 
_reflns.d_resolution_low                               50.44 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     69593 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           100.0 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                13.0 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          5.3 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.434 
_reflns.pdbx_Rpim_I_all                                0.165 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.992 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.402 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
loop_
_reflns_shell.d_res_high 
_reflns_shell.d_res_low 
_reflns_shell.meanI_over_sigI_all 
_reflns_shell.meanI_over_sigI_obs 
_reflns_shell.number_measured_all 
_reflns_shell.number_measured_obs 
_reflns_shell.number_possible 
_reflns_shell.number_unique_all 
_reflns_shell.number_unique_obs 
_reflns_shell.percent_possible_obs 
_reflns_shell.Rmerge_F_all 
_reflns_shell.Rmerge_F_obs 
_reflns_shell.meanI_over_sigI_gt 
_reflns_shell.meanI_over_uI_all 
_reflns_shell.meanI_over_uI_gt 
_reflns_shell.number_measured_gt 
_reflns_shell.number_unique_gt 
_reflns_shell.percent_possible_gt 
_reflns_shell.Rmerge_F_gt 
_reflns_shell.Rmerge_I_gt 
_reflns_shell.pdbx_redundancy 
_reflns_shell.pdbx_chi_squared 
_reflns_shell.pdbx_netI_over_sigmaI_all 
_reflns_shell.pdbx_netI_over_sigmaI_obs 
_reflns_shell.pdbx_Rrim_I_all 
_reflns_shell.pdbx_Rpim_I_all 
_reflns_shell.pdbx_rejects 
_reflns_shell.pdbx_ordinal 
_reflns_shell.pdbx_diffrn_id 
_reflns_shell.pdbx_CC_half 
_reflns_shell.pdbx_CC_star 
_reflns_shell.pdbx_R_split 
_reflns_shell.percent_possible_all 
_reflns_shell.Rmerge_I_all 
_reflns_shell.Rmerge_I_obs 
_reflns_shell.pdbx_Rsym_value 
_reflns_shell.pdbx_percent_possible_ellipsoidal 
_reflns_shell.pdbx_percent_possible_spherical 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous 
_reflns_shell.pdbx_percent_possible_spherical_anomalous 
_reflns_shell.pdbx_redundancy_anomalous 
_reflns_shell.pdbx_CC_half_anomalous 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous 
_reflns_shell.pdbx_percent_possible_anomalous 
9.09 50.44 ? ? ? ? ? ? 6845 ? ? ? ? ? ? ? ? ? ? ? 11.3 ? ? ? 0.060 0.022 ? 1 1 0.999 ? ? 99.5 ? 0.055 ? ? ? ? ? ? ? ? ? 
1.75 1.78  ? ? ? ? ? ? 6845 ? ? ? ? ? ? ? ? ? ? ? 12.6 ? ? ? 5.662 2.205 ? 2 1 0.199 ? ? ?    ? 5.210 ? ? ? ? ? ? ? ? ? 
# 
_refine.aniso_B[1][1]                            -1.99 
_refine.aniso_B[1][2]                            0.00 
_refine.aniso_B[1][3]                            -0.00 
_refine.aniso_B[2][2]                            1.40 
_refine.aniso_B[2][3]                            0.00 
_refine.aniso_B[3][3]                            0.58 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               24.944 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.959 
_refine.correlation_coeff_Fo_to_Fc_free          0.935 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9HT4 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.75 
_refine.ls_d_res_low                             50.44 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     65952 
_refine.ls_number_reflns_R_free                  3530 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.96 
_refine.ls_percent_reflns_R_free                 5.1 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.20307 
_refine.ls_R_factor_R_free                       0.24125 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.20097 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.122 
_refine.pdbx_overall_ESU_R_Free                  0.121 
_refine.pdbx_solvent_vdw_probe_radii             1.20 
_refine.pdbx_solvent_ion_probe_radii             0.80 
_refine.pdbx_solvent_shrinkage_radii             0.80 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             4.318 
_refine.overall_SU_ML                            0.123 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         1 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.75 
_refine_hist.d_res_low                        50.44 
_refine_hist.number_atoms_solvent             320 
_refine_hist.number_atoms_total               5210 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        4874 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         16 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.015  0.012  4990 ? r_bond_refined_d             ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_bond_other_d               ? ? 
'X-RAY DIFFRACTION' ? 2.553  1.833  6735 ? r_angle_refined_deg          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_angle_other_deg            ? ? 
'X-RAY DIFFRACTION' ? 6.646  5.000  610  ? r_dihedral_angle_1_deg       ? ? 
'X-RAY DIFFRACTION' ? 11.624 5.000  44   ? r_dihedral_angle_2_deg       ? ? 
'X-RAY DIFFRACTION' ? 15.098 10.000 886  ? r_dihedral_angle_3_deg       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_dihedral_angle_4_deg       ? ? 
'X-RAY DIFFRACTION' ? 0.159  0.200  723  ? r_chiral_restr               ? ? 
'X-RAY DIFFRACTION' ? 0.014  0.020  3864 ? r_gen_planes_refined         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_gen_planes_other           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbd_refined                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbd_other                  ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbtor_refined              ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbtor_other                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_xyhbond_nbd_refined        ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_xyhbond_nbd_other          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_metal_ion_refined          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_metal_ion_other            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_vdw_refined       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_vdw_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_hbond_refined     ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_hbond_other       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_metal_ion_refined ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_metal_ion_other   ? ? 
'X-RAY DIFFRACTION' ? 2.985  2.223  2443 ? r_mcbond_it                  ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_mcbond_other               ? ? 
'X-RAY DIFFRACTION' ? 3.862  3.984  3052 ? r_mcangle_it                 ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_mcangle_other              ? ? 
'X-RAY DIFFRACTION' ? 5.417  2.629  2547 ? r_scbond_it                  ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_scbond_other               ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_scangle_it                 ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_scangle_other              ? ? 
'X-RAY DIFFRACTION' ? 7.970  24.44  7775 ? r_long_range_B_refined       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_long_range_B_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_rigid_bond_restr           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_sphericity_free            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_sphericity_bonded          ? ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.d_res_high                       1.750 
_refine_ls_shell.d_res_low                        1.795 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.number_reflns_obs                ? 
_refine_ls_shell.number_reflns_R_free             215 
_refine_ls_shell.number_reflns_R_work             4895 
_refine_ls_shell.percent_reflns_obs               100.00 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.R_factor_R_work                  0.373 
_refine_ls_shell.redundancy_reflns_all            ? 
_refine_ls_shell.redundancy_reflns_obs            ? 
_refine_ls_shell.wR_factor_all                    ? 
_refine_ls_shell.wR_factor_obs                    ? 
_refine_ls_shell.wR_factor_R_free                 ? 
_refine_ls_shell.wR_factor_R_work                 ? 
_refine_ls_shell.pdbx_R_complete                  ? 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.pdbx_phase_error                 ? 
_refine_ls_shell.pdbx_fsc_work                    ? 
_refine_ls_shell.pdbx_fsc_free                    ? 
_refine_ls_shell.R_factor_R_free                  0.380 
# 
_struct.entry_id                     9HT4 
_struct.title                        
;Crystal structure of PA0884, the SBP component of a Pseudomonas aeruginosa PAO1 Tripartite ATP-independent Periplasmic (TRAP) transporter, complexed with succinate
;
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9HT4 
_struct_keywords.text            'periplasmic substrate binding protein, C4-dicarboxylate transport, succinate, TRANSPORT PROTEIN' 
_struct_keywords.pdbx_keywords   'TRANSPORT PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 2 ? 
E N N 3 ? 
F N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    Q9I561_PSEAE 
_struct_ref.pdbx_db_accession          Q9I561 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;AQPIVIKFSHVVAENTPKGQGALLFKKLVEQRLGGRVEVDVYPNSSLFGDGKEMEALLLGDVQMLAPSLAKFEQYTRKVQ
IFDLPFLFDDIQAVDRFQRSPQGRALLTSMQGKGILGLAYWHNGMKQLSANRPLLEPEDARGLKFRVQASDVLNEQFRQL
RAISRKMSFAEVYQGLQTGVVNGTENTWSNYESQKVNEVQKYFTESNHGLVDYMVITNAKFWNGLPADIREELQRIMDEV
TVQVNLEAERLNRDARQRILASGASEIHTLSPQQRADWRQAMQPVWQKFRGNVGADLLQAAEASNRPD
;
_struct_ref.pdbx_align_begin           24 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9HT4 A 1 ? 308 ? Q9I561 24 ? 331 ? 24 331 
2 1 9HT4 B 1 ? 308 ? Q9I561 24 ? 331 ? 24 331 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 author_defined_assembly ? monomeric 1 
2 author_defined_assembly ? monomeric 1 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1 A,C,E 
2 1 B,D,F 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 THR A 16  ? LEU A 33  ? THR A 39  LEU A 56  1 ? 18 
HELX_P HELX_P2  AA2 GLY A 51  ? GLY A 60  ? GLY A 74  GLY A 83  1 ? 10 
HELX_P HELX_P3  AA3 SER A 68  ? PHE A 72  ? SER A 91  PHE A 95  5 ? 5  
HELX_P HELX_P4  AA4 LYS A 78  ? LEU A 84  ? LYS A 101 LEU A 107 5 ? 7  
HELX_P HELX_P5  AA5 ASP A 90  ? SER A 100 ? ASP A 113 SER A 123 1 ? 11 
HELX_P HELX_P6  AA6 SER A 100 ? LEU A 106 ? SER A 123 LEU A 129 1 ? 7  
HELX_P HELX_P7  AA7 LEU A 107 ? SER A 109 ? LEU A 130 SER A 132 5 ? 3  
HELX_P HELX_P8  AA8 MET A 110 ? LYS A 113 ? MET A 133 LYS A 136 5 ? 4  
HELX_P HELX_P9  AA9 GLU A 136 ? ARG A 141 ? GLU A 159 ARG A 164 5 ? 6  
HELX_P HELX_P10 AB1 SER A 150 ? LEU A 160 ? SER A 173 LEU A 183 1 ? 11 
HELX_P HELX_P11 AB2 SER A 168 ? ALA A 170 ? SER A 191 ALA A 193 5 ? 3  
HELX_P HELX_P12 AB3 GLU A 171 ? THR A 178 ? GLU A 194 THR A 201 1 ? 8  
HELX_P HELX_P13 AB4 THR A 187 ? GLN A 194 ? THR A 210 GLN A 217 1 ? 8  
HELX_P HELX_P14 AB5 LYS A 195 ? GLN A 200 ? LYS A 218 GLN A 223 5 ? 6  
HELX_P HELX_P15 AB6 ALA A 219 ? GLY A 224 ? ALA A 242 GLY A 247 1 ? 6  
HELX_P HELX_P16 AB7 PRO A 226 ? GLY A 263 ? PRO A 249 GLY A 286 1 ? 38 
HELX_P HELX_P17 AB8 SER A 271 ? GLN A 283 ? SER A 294 GLN A 306 1 ? 13 
HELX_P HELX_P18 AB9 PRO A 284 ? LYS A 288 ? PRO A 307 LYS A 311 5 ? 5  
HELX_P HELX_P19 AC1 PHE A 289 ? GLY A 294 ? PHE A 312 GLY A 317 1 ? 6  
HELX_P HELX_P20 AC2 GLY A 294 ? SER A 304 ? GLY A 317 SER A 327 1 ? 11 
HELX_P HELX_P21 AC3 THR B 16  ? LEU B 33  ? THR B 39  LEU B 56  1 ? 18 
HELX_P HELX_P22 AC4 GLY B 51  ? GLY B 60  ? GLY B 74  GLY B 83  1 ? 10 
HELX_P HELX_P23 AC5 SER B 68  ? PHE B 72  ? SER B 91  PHE B 95  5 ? 5  
HELX_P HELX_P24 AC6 LYS B 78  ? LEU B 84  ? LYS B 101 LEU B 107 5 ? 7  
HELX_P HELX_P25 AC7 ASP B 90  ? SER B 100 ? ASP B 113 SER B 123 1 ? 11 
HELX_P HELX_P26 AC8 SER B 100 ? LEU B 106 ? SER B 123 LEU B 129 1 ? 7  
HELX_P HELX_P27 AC9 LEU B 107 ? SER B 109 ? LEU B 130 SER B 132 5 ? 3  
HELX_P HELX_P28 AD1 MET B 110 ? LYS B 113 ? MET B 133 LYS B 136 5 ? 4  
HELX_P HELX_P29 AD2 GLU B 136 ? ARG B 141 ? GLU B 159 ARG B 164 5 ? 6  
HELX_P HELX_P30 AD3 SER B 150 ? LEU B 160 ? SER B 173 LEU B 183 1 ? 11 
HELX_P HELX_P31 AD4 SER B 168 ? ALA B 170 ? SER B 191 ALA B 193 5 ? 3  
HELX_P HELX_P32 AD5 GLU B 171 ? THR B 178 ? GLU B 194 THR B 201 1 ? 8  
HELX_P HELX_P33 AD6 THR B 187 ? GLN B 194 ? THR B 210 GLN B 217 1 ? 8  
HELX_P HELX_P34 AD7 LYS B 195 ? GLN B 200 ? LYS B 218 GLN B 223 5 ? 6  
HELX_P HELX_P35 AD8 ALA B 219 ? GLY B 224 ? ALA B 242 GLY B 247 1 ? 6  
HELX_P HELX_P36 AD9 PRO B 226 ? GLY B 263 ? PRO B 249 GLY B 286 1 ? 38 
HELX_P HELX_P37 AE1 SER B 271 ? GLN B 283 ? SER B 294 GLN B 306 1 ? 13 
HELX_P HELX_P38 AE2 VAL B 285 ? GLY B 294 ? VAL B 308 GLY B 317 1 ? 10 
HELX_P HELX_P39 AE3 GLY B 294 ? SER B 304 ? GLY B 317 SER B 327 1 ? 11 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 2 ? 
AA2 ? 6 ? 
AA3 ? 3 ? 
AA4 ? 2 ? 
AA5 ? 6 ? 
AA6 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? parallel      
AA2 5 6 ? parallel      
AA3 1 2 ? anti-parallel 
AA3 2 3 ? parallel      
AA4 1 2 ? parallel      
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA5 4 5 ? parallel      
AA5 5 6 ? parallel      
AA6 1 2 ? anti-parallel 
AA6 2 3 ? parallel      
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ILE A 4   ? SER A 9   ? ILE A 27  SER A 32  
AA1 2 VAL A 37  ? TYR A 42  ? VAL A 60  TYR A 65  
AA2 1 MET A 64  ? LEU A 65  ? MET A 87  LEU A 88  
AA2 2 TYR A 202 ? ASN A 218 ? TYR A 225 ASN A 241 
AA2 3 ILE A 115 ? ALA A 130 ? ILE A 138 ALA A 153 
AA2 4 GLY A 183 ? ASN A 186 ? GLY A 206 ASN A 209 
AA2 5 LYS A 144 ? VAL A 147 ? LYS A 167 VAL A 170 
AA2 6 ILE A 163 ? LYS A 166 ? ILE A 186 LYS A 189 
AA3 1 MET A 64  ? LEU A 65  ? MET A 87  LEU A 88  
AA3 2 TYR A 202 ? ASN A 218 ? TYR A 225 ASN A 241 
AA3 3 GLU A 266 ? THR A 269 ? GLU A 289 THR A 292 
AA4 1 ILE B 4   ? SER B 9   ? ILE B 27  SER B 32  
AA4 2 VAL B 37  ? TYR B 42  ? VAL B 60  TYR B 65  
AA5 1 MET B 64  ? LEU B 65  ? MET B 87  LEU B 88  
AA5 2 TYR B 202 ? ASN B 218 ? TYR B 225 ASN B 241 
AA5 3 ILE B 115 ? ALA B 130 ? ILE B 138 ALA B 153 
AA5 4 GLY B 183 ? ASN B 186 ? GLY B 206 ASN B 209 
AA5 5 LYS B 144 ? VAL B 147 ? LYS B 167 VAL B 170 
AA5 6 ILE B 163 ? LYS B 166 ? ILE B 186 LYS B 189 
AA6 1 MET B 64  ? LEU B 65  ? MET B 87  LEU B 88  
AA6 2 TYR B 202 ? ASN B 218 ? TYR B 225 ASN B 241 
AA6 3 GLU B 266 ? THR B 269 ? GLU B 289 THR B 292 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N PHE A 8   ? N PHE A 31  O ASP A 40  ? O ASP A 63  
AA2 1 2 N LEU A 65  ? N LEU A 88  O ILE A 216 ? O ILE A 239 
AA2 2 3 O VAL A 215 ? O VAL A 238 N LEU A 118 ? N LEU A 141 
AA2 3 4 N GLN A 127 ? N GLN A 150 O ASN A 186 ? O ASN A 209 
AA2 4 5 O GLY A 183 ? O GLY A 206 N ARG A 146 ? N ARG A 169 
AA2 5 6 N PHE A 145 ? N PHE A 168 O ILE A 163 ? O ILE A 186 
AA3 1 2 N LEU A 65  ? N LEU A 88  O ILE A 216 ? O ILE A 239 
AA3 2 3 N PHE A 203 ? N PHE A 226 O GLU A 266 ? O GLU A 289 
AA4 1 2 N ILE B 4   ? N ILE B 27  O GLU B 38  ? O GLU B 61  
AA5 1 2 N LEU B 65  ? N LEU B 88  O ILE B 216 ? O ILE B 239 
AA5 2 3 O VAL B 215 ? O VAL B 238 N LEU B 118 ? N LEU B 141 
AA5 3 4 N GLN B 127 ? N GLN B 150 O ASN B 186 ? O ASN B 209 
AA5 4 5 O GLY B 183 ? O GLY B 206 N ARG B 146 ? N ARG B 169 
AA5 5 6 N PHE B 145 ? N PHE B 168 O ILE B 163 ? O ILE B 186 
AA6 1 2 N LEU B 65  ? N LEU B 88  O ILE B 216 ? O ILE B 239 
AA6 2 3 N PHE B 203 ? N PHE B 226 O HIS B 268 ? O HIS B 291 
# 
_pdbx_entry_details.entry_id                   9HT4 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASN A 146 ? ? -118.90 -74.60  
2 1 ALA A 172 ? ? -66.20  74.48   
3 1 THR A 207 ? ? -162.51 -167.60 
4 1 LEU B 70  ? ? -99.66  -61.08  
5 1 ASN B 146 ? ? -118.18 -74.86  
# 
loop_
_pdbx_validate_planes.id 
_pdbx_validate_planes.PDB_model_num 
_pdbx_validate_planes.auth_comp_id 
_pdbx_validate_planes.auth_asym_id 
_pdbx_validate_planes.auth_seq_id 
_pdbx_validate_planes.PDB_ins_code 
_pdbx_validate_planes.label_alt_id 
_pdbx_validate_planes.rmsd 
_pdbx_validate_planes.type 
1  1 ARG A 100 ? ? 0.275 'SIDE CHAIN' 
2  1 ARG A 181 ? ? 0.259 'SIDE CHAIN' 
3  1 ARG A 298 ? ? 0.089 'SIDE CHAIN' 
4  1 ARG A 313 ? ? 0.184 'SIDE CHAIN' 
5  1 ARG A 329 ? ? 0.189 'SIDE CHAIN' 
6  1 ARG B 59  ? ? 0.230 'SIDE CHAIN' 
7  1 ARG B 100 ? ? 0.289 'SIDE CHAIN' 
8  1 ARG B 122 ? ? 0.263 'SIDE CHAIN' 
9  1 ARG B 127 ? ? 0.110 'SIDE CHAIN' 
10 1 ARG B 164 ? ? 0.087 'SIDE CHAIN' 
11 1 ARG B 181 ? ? 0.249 'SIDE CHAIN' 
12 1 ARG B 184 ? ? 0.269 'SIDE CHAIN' 
13 1 ARG B 273 ? ? 0.106 'SIDE CHAIN' 
14 1 ARG B 302 ? ? 0.084 'SIDE CHAIN' 
15 1 ARG B 329 ? ? 0.196 'SIDE CHAIN' 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A ALA 24  ? A ALA 1   
2 1 Y 1 A GLN 25  ? A GLN 2   
3 1 Y 1 A ASP 331 ? A ASP 308 
4 1 Y 1 B ALA 24  ? B ALA 1   
5 1 Y 1 B GLN 25  ? B GLN 2   
6 1 Y 1 B ASP 331 ? B ASP 308 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
GLN N    N N N 74  
GLN CA   C N S 75  
GLN C    C N N 76  
GLN O    O N N 77  
GLN CB   C N N 78  
GLN CG   C N N 79  
GLN CD   C N N 80  
GLN OE1  O N N 81  
GLN NE2  N N N 82  
GLN OXT  O N N 83  
GLN H    H N N 84  
GLN H2   H N N 85  
GLN HA   H N N 86  
GLN HB2  H N N 87  
GLN HB3  H N N 88  
GLN HG2  H N N 89  
GLN HG3  H N N 90  
GLN HE21 H N N 91  
GLN HE22 H N N 92  
GLN HXT  H N N 93  
GLU N    N N N 94  
GLU CA   C N S 95  
GLU C    C N N 96  
GLU O    O N N 97  
GLU CB   C N N 98  
GLU CG   C N N 99  
GLU CD   C N N 100 
GLU OE1  O N N 101 
GLU OE2  O N N 102 
GLU OXT  O N N 103 
GLU H    H N N 104 
GLU H2   H N N 105 
GLU HA   H N N 106 
GLU HB2  H N N 107 
GLU HB3  H N N 108 
GLU HG2  H N N 109 
GLU HG3  H N N 110 
GLU HE2  H N N 111 
GLU HXT  H N N 112 
GLY N    N N N 113 
GLY CA   C N N 114 
GLY C    C N N 115 
GLY O    O N N 116 
GLY OXT  O N N 117 
GLY H    H N N 118 
GLY H2   H N N 119 
GLY HA2  H N N 120 
GLY HA3  H N N 121 
GLY HXT  H N N 122 
HIS N    N N N 123 
HIS CA   C N S 124 
HIS C    C N N 125 
HIS O    O N N 126 
HIS CB   C N N 127 
HIS CG   C Y N 128 
HIS ND1  N Y N 129 
HIS CD2  C Y N 130 
HIS CE1  C Y N 131 
HIS NE2  N Y N 132 
HIS OXT  O N N 133 
HIS H    H N N 134 
HIS H2   H N N 135 
HIS HA   H N N 136 
HIS HB2  H N N 137 
HIS HB3  H N N 138 
HIS HD1  H N N 139 
HIS HD2  H N N 140 
HIS HE1  H N N 141 
HIS HE2  H N N 142 
HIS HXT  H N N 143 
HOH O    O N N 144 
HOH H1   H N N 145 
HOH H2   H N N 146 
ILE N    N N N 147 
ILE CA   C N S 148 
ILE C    C N N 149 
ILE O    O N N 150 
ILE CB   C N S 151 
ILE CG1  C N N 152 
ILE CG2  C N N 153 
ILE CD1  C N N 154 
ILE OXT  O N N 155 
ILE H    H N N 156 
ILE H2   H N N 157 
ILE HA   H N N 158 
ILE HB   H N N 159 
ILE HG12 H N N 160 
ILE HG13 H N N 161 
ILE HG21 H N N 162 
ILE HG22 H N N 163 
ILE HG23 H N N 164 
ILE HD11 H N N 165 
ILE HD12 H N N 166 
ILE HD13 H N N 167 
ILE HXT  H N N 168 
LEU N    N N N 169 
LEU CA   C N S 170 
LEU C    C N N 171 
LEU O    O N N 172 
LEU CB   C N N 173 
LEU CG   C N N 174 
LEU CD1  C N N 175 
LEU CD2  C N N 176 
LEU OXT  O N N 177 
LEU H    H N N 178 
LEU H2   H N N 179 
LEU HA   H N N 180 
LEU HB2  H N N 181 
LEU HB3  H N N 182 
LEU HG   H N N 183 
LEU HD11 H N N 184 
LEU HD12 H N N 185 
LEU HD13 H N N 186 
LEU HD21 H N N 187 
LEU HD22 H N N 188 
LEU HD23 H N N 189 
LEU HXT  H N N 190 
LYS N    N N N 191 
LYS CA   C N S 192 
LYS C    C N N 193 
LYS O    O N N 194 
LYS CB   C N N 195 
LYS CG   C N N 196 
LYS CD   C N N 197 
LYS CE   C N N 198 
LYS NZ   N N N 199 
LYS OXT  O N N 200 
LYS H    H N N 201 
LYS H2   H N N 202 
LYS HA   H N N 203 
LYS HB2  H N N 204 
LYS HB3  H N N 205 
LYS HG2  H N N 206 
LYS HG3  H N N 207 
LYS HD2  H N N 208 
LYS HD3  H N N 209 
LYS HE2  H N N 210 
LYS HE3  H N N 211 
LYS HZ1  H N N 212 
LYS HZ2  H N N 213 
LYS HZ3  H N N 214 
LYS HXT  H N N 215 
MET N    N N N 216 
MET CA   C N S 217 
MET C    C N N 218 
MET O    O N N 219 
MET CB   C N N 220 
MET CG   C N N 221 
MET SD   S N N 222 
MET CE   C N N 223 
MET OXT  O N N 224 
MET H    H N N 225 
MET H2   H N N 226 
MET HA   H N N 227 
MET HB2  H N N 228 
MET HB3  H N N 229 
MET HG2  H N N 230 
MET HG3  H N N 231 
MET HE1  H N N 232 
MET HE2  H N N 233 
MET HE3  H N N 234 
MET HXT  H N N 235 
PHE N    N N N 236 
PHE CA   C N S 237 
PHE C    C N N 238 
PHE O    O N N 239 
PHE CB   C N N 240 
PHE CG   C Y N 241 
PHE CD1  C Y N 242 
PHE CD2  C Y N 243 
PHE CE1  C Y N 244 
PHE CE2  C Y N 245 
PHE CZ   C Y N 246 
PHE OXT  O N N 247 
PHE H    H N N 248 
PHE H2   H N N 249 
PHE HA   H N N 250 
PHE HB2  H N N 251 
PHE HB3  H N N 252 
PHE HD1  H N N 253 
PHE HD2  H N N 254 
PHE HE1  H N N 255 
PHE HE2  H N N 256 
PHE HZ   H N N 257 
PHE HXT  H N N 258 
PRO N    N N N 259 
PRO CA   C N S 260 
PRO C    C N N 261 
PRO O    O N N 262 
PRO CB   C N N 263 
PRO CG   C N N 264 
PRO CD   C N N 265 
PRO OXT  O N N 266 
PRO H    H N N 267 
PRO HA   H N N 268 
PRO HB2  H N N 269 
PRO HB3  H N N 270 
PRO HG2  H N N 271 
PRO HG3  H N N 272 
PRO HD2  H N N 273 
PRO HD3  H N N 274 
PRO HXT  H N N 275 
SER N    N N N 276 
SER CA   C N S 277 
SER C    C N N 278 
SER O    O N N 279 
SER CB   C N N 280 
SER OG   O N N 281 
SER OXT  O N N 282 
SER H    H N N 283 
SER H2   H N N 284 
SER HA   H N N 285 
SER HB2  H N N 286 
SER HB3  H N N 287 
SER HG   H N N 288 
SER HXT  H N N 289 
SIN C1   C N N 290 
SIN O1   O N N 291 
SIN O2   O N N 292 
SIN C2   C N N 293 
SIN C3   C N N 294 
SIN C4   C N N 295 
SIN O3   O N N 296 
SIN O4   O N N 297 
SIN HO2  H N N 298 
SIN H21  H N N 299 
SIN H22  H N N 300 
SIN H31  H N N 301 
SIN H32  H N N 302 
SIN HO4  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
VAL N    N N N 372 
VAL CA   C N S 373 
VAL C    C N N 374 
VAL O    O N N 375 
VAL CB   C N N 376 
VAL CG1  C N N 377 
VAL CG2  C N N 378 
VAL OXT  O N N 379 
VAL H    H N N 380 
VAL H2   H N N 381 
VAL HA   H N N 382 
VAL HB   H N N 383 
VAL HG11 H N N 384 
VAL HG12 H N N 385 
VAL HG13 H N N 386 
VAL HG21 H N N 387 
VAL HG22 H N N 388 
VAL HG23 H N N 389 
VAL HXT  H N N 390 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
GLN N   CA   sing N N 70  
GLN N   H    sing N N 71  
GLN N   H2   sing N N 72  
GLN CA  C    sing N N 73  
GLN CA  CB   sing N N 74  
GLN CA  HA   sing N N 75  
GLN C   O    doub N N 76  
GLN C   OXT  sing N N 77  
GLN CB  CG   sing N N 78  
GLN CB  HB2  sing N N 79  
GLN CB  HB3  sing N N 80  
GLN CG  CD   sing N N 81  
GLN CG  HG2  sing N N 82  
GLN CG  HG3  sing N N 83  
GLN CD  OE1  doub N N 84  
GLN CD  NE2  sing N N 85  
GLN NE2 HE21 sing N N 86  
GLN NE2 HE22 sing N N 87  
GLN OXT HXT  sing N N 88  
GLU N   CA   sing N N 89  
GLU N   H    sing N N 90  
GLU N   H2   sing N N 91  
GLU CA  C    sing N N 92  
GLU CA  CB   sing N N 93  
GLU CA  HA   sing N N 94  
GLU C   O    doub N N 95  
GLU C   OXT  sing N N 96  
GLU CB  CG   sing N N 97  
GLU CB  HB2  sing N N 98  
GLU CB  HB3  sing N N 99  
GLU CG  CD   sing N N 100 
GLU CG  HG2  sing N N 101 
GLU CG  HG3  sing N N 102 
GLU CD  OE1  doub N N 103 
GLU CD  OE2  sing N N 104 
GLU OE2 HE2  sing N N 105 
GLU OXT HXT  sing N N 106 
GLY N   CA   sing N N 107 
GLY N   H    sing N N 108 
GLY N   H2   sing N N 109 
GLY CA  C    sing N N 110 
GLY CA  HA2  sing N N 111 
GLY CA  HA3  sing N N 112 
GLY C   O    doub N N 113 
GLY C   OXT  sing N N 114 
GLY OXT HXT  sing N N 115 
HIS N   CA   sing N N 116 
HIS N   H    sing N N 117 
HIS N   H2   sing N N 118 
HIS CA  C    sing N N 119 
HIS CA  CB   sing N N 120 
HIS CA  HA   sing N N 121 
HIS C   O    doub N N 122 
HIS C   OXT  sing N N 123 
HIS CB  CG   sing N N 124 
HIS CB  HB2  sing N N 125 
HIS CB  HB3  sing N N 126 
HIS CG  ND1  sing Y N 127 
HIS CG  CD2  doub Y N 128 
HIS ND1 CE1  doub Y N 129 
HIS ND1 HD1  sing N N 130 
HIS CD2 NE2  sing Y N 131 
HIS CD2 HD2  sing N N 132 
HIS CE1 NE2  sing Y N 133 
HIS CE1 HE1  sing N N 134 
HIS NE2 HE2  sing N N 135 
HIS OXT HXT  sing N N 136 
HOH O   H1   sing N N 137 
HOH O   H2   sing N N 138 
ILE N   CA   sing N N 139 
ILE N   H    sing N N 140 
ILE N   H2   sing N N 141 
ILE CA  C    sing N N 142 
ILE CA  CB   sing N N 143 
ILE CA  HA   sing N N 144 
ILE C   O    doub N N 145 
ILE C   OXT  sing N N 146 
ILE CB  CG1  sing N N 147 
ILE CB  CG2  sing N N 148 
ILE CB  HB   sing N N 149 
ILE CG1 CD1  sing N N 150 
ILE CG1 HG12 sing N N 151 
ILE CG1 HG13 sing N N 152 
ILE CG2 HG21 sing N N 153 
ILE CG2 HG22 sing N N 154 
ILE CG2 HG23 sing N N 155 
ILE CD1 HD11 sing N N 156 
ILE CD1 HD12 sing N N 157 
ILE CD1 HD13 sing N N 158 
ILE OXT HXT  sing N N 159 
LEU N   CA   sing N N 160 
LEU N   H    sing N N 161 
LEU N   H2   sing N N 162 
LEU CA  C    sing N N 163 
LEU CA  CB   sing N N 164 
LEU CA  HA   sing N N 165 
LEU C   O    doub N N 166 
LEU C   OXT  sing N N 167 
LEU CB  CG   sing N N 168 
LEU CB  HB2  sing N N 169 
LEU CB  HB3  sing N N 170 
LEU CG  CD1  sing N N 171 
LEU CG  CD2  sing N N 172 
LEU CG  HG   sing N N 173 
LEU CD1 HD11 sing N N 174 
LEU CD1 HD12 sing N N 175 
LEU CD1 HD13 sing N N 176 
LEU CD2 HD21 sing N N 177 
LEU CD2 HD22 sing N N 178 
LEU CD2 HD23 sing N N 179 
LEU OXT HXT  sing N N 180 
LYS N   CA   sing N N 181 
LYS N   H    sing N N 182 
LYS N   H2   sing N N 183 
LYS CA  C    sing N N 184 
LYS CA  CB   sing N N 185 
LYS CA  HA   sing N N 186 
LYS C   O    doub N N 187 
LYS C   OXT  sing N N 188 
LYS CB  CG   sing N N 189 
LYS CB  HB2  sing N N 190 
LYS CB  HB3  sing N N 191 
LYS CG  CD   sing N N 192 
LYS CG  HG2  sing N N 193 
LYS CG  HG3  sing N N 194 
LYS CD  CE   sing N N 195 
LYS CD  HD2  sing N N 196 
LYS CD  HD3  sing N N 197 
LYS CE  NZ   sing N N 198 
LYS CE  HE2  sing N N 199 
LYS CE  HE3  sing N N 200 
LYS NZ  HZ1  sing N N 201 
LYS NZ  HZ2  sing N N 202 
LYS NZ  HZ3  sing N N 203 
LYS OXT HXT  sing N N 204 
MET N   CA   sing N N 205 
MET N   H    sing N N 206 
MET N   H2   sing N N 207 
MET CA  C    sing N N 208 
MET CA  CB   sing N N 209 
MET CA  HA   sing N N 210 
MET C   O    doub N N 211 
MET C   OXT  sing N N 212 
MET CB  CG   sing N N 213 
MET CB  HB2  sing N N 214 
MET CB  HB3  sing N N 215 
MET CG  SD   sing N N 216 
MET CG  HG2  sing N N 217 
MET CG  HG3  sing N N 218 
MET SD  CE   sing N N 219 
MET CE  HE1  sing N N 220 
MET CE  HE2  sing N N 221 
MET CE  HE3  sing N N 222 
MET OXT HXT  sing N N 223 
PHE N   CA   sing N N 224 
PHE N   H    sing N N 225 
PHE N   H2   sing N N 226 
PHE CA  C    sing N N 227 
PHE CA  CB   sing N N 228 
PHE CA  HA   sing N N 229 
PHE C   O    doub N N 230 
PHE C   OXT  sing N N 231 
PHE CB  CG   sing N N 232 
PHE CB  HB2  sing N N 233 
PHE CB  HB3  sing N N 234 
PHE CG  CD1  doub Y N 235 
PHE CG  CD2  sing Y N 236 
PHE CD1 CE1  sing Y N 237 
PHE CD1 HD1  sing N N 238 
PHE CD2 CE2  doub Y N 239 
PHE CD2 HD2  sing N N 240 
PHE CE1 CZ   doub Y N 241 
PHE CE1 HE1  sing N N 242 
PHE CE2 CZ   sing Y N 243 
PHE CE2 HE2  sing N N 244 
PHE CZ  HZ   sing N N 245 
PHE OXT HXT  sing N N 246 
PRO N   CA   sing N N 247 
PRO N   CD   sing N N 248 
PRO N   H    sing N N 249 
PRO CA  C    sing N N 250 
PRO CA  CB   sing N N 251 
PRO CA  HA   sing N N 252 
PRO C   O    doub N N 253 
PRO C   OXT  sing N N 254 
PRO CB  CG   sing N N 255 
PRO CB  HB2  sing N N 256 
PRO CB  HB3  sing N N 257 
PRO CG  CD   sing N N 258 
PRO CG  HG2  sing N N 259 
PRO CG  HG3  sing N N 260 
PRO CD  HD2  sing N N 261 
PRO CD  HD3  sing N N 262 
PRO OXT HXT  sing N N 263 
SER N   CA   sing N N 264 
SER N   H    sing N N 265 
SER N   H2   sing N N 266 
SER CA  C    sing N N 267 
SER CA  CB   sing N N 268 
SER CA  HA   sing N N 269 
SER C   O    doub N N 270 
SER C   OXT  sing N N 271 
SER CB  OG   sing N N 272 
SER CB  HB2  sing N N 273 
SER CB  HB3  sing N N 274 
SER OG  HG   sing N N 275 
SER OXT HXT  sing N N 276 
SIN C1  O1   doub N N 277 
SIN C1  O2   sing N N 278 
SIN C1  C2   sing N N 279 
SIN O2  HO2  sing N N 280 
SIN C2  C3   sing N N 281 
SIN C2  H21  sing N N 282 
SIN C2  H22  sing N N 283 
SIN C3  C4   sing N N 284 
SIN C3  H31  sing N N 285 
SIN C3  H32  sing N N 286 
SIN C4  O3   doub N N 287 
SIN C4  O4   sing N N 288 
SIN O4  HO4  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
# 
_pdbx_audit_support.funding_organization   'Biotechnology and Biological Sciences Research Council (BBSRC)' 
_pdbx_audit_support.country                'United Kingdom' 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'in silico model' 
_pdbx_initial_refinement_model.source_name      AlphaFold 
_pdbx_initial_refinement_model.accession_code   AF-Q9I561-F1 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9HT4 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.029449 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   -0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.008437 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   -0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.005981 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.pdbx_scat_Z 
_atom_type.pdbx_N_electrons 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
C 6  6  2.3103  20.8439 1.0201 10.2075 1.5888 0.5687  0.8651 51.6512 0.2156   
H 1  1  0.4930  10.5109 0.3229 26.1257 0.1402 3.1424  0.0408 57.7997 0.0030   
N 7  7  12.2220 0.0057  3.1346 9.8933  2.0141 28.9975 1.1672 0.5826  -11.5379 
O 8  8  3.0487  13.2771 2.2870 5.7011  1.5464 0.3239  0.8671 32.9089 0.2508   
S 16 16 6.9054  1.4679  5.2035 22.2151 1.4379 0.2536  1.5863 56.1720 1.0486   
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
_atom_site.calc_flag 
ATOM   1    N N   . PRO A 1 3   ? 9.919   -0.102  52.135 1.00 28.24  ? 26  PRO A N   1 ? 
ATOM   2    C CA  . PRO A 1 3   ? 10.567  0.482   50.974 1.00 23.42  ? 26  PRO A CA  1 ? 
ATOM   3    C C   . PRO A 1 3   ? 9.674   1.425   50.167 1.00 23.35  ? 26  PRO A C   1 ? 
ATOM   4    O O   . PRO A 1 3   ? 8.567   1.019   49.809 1.00 24.71  ? 26  PRO A O   1 ? 
ATOM   5    C CB  . PRO A 1 3   ? 10.964  -0.767  50.179 1.00 24.04  ? 26  PRO A CB  1 ? 
ATOM   6    C CG  . PRO A 1 3   ? 11.319  -1.769  51.219 1.00 25.74  ? 26  PRO A CG  1 ? 
ATOM   7    C CD  . PRO A 1 3   ? 10.230  -1.530  52.236 1.00 30.22  ? 26  PRO A CD  1 ? 
ATOM   8    N N   . ILE A 1 4   ? 10.142  2.649   49.921 1.00 23.67  ? 27  ILE A N   1 ? 
ATOM   9    C CA  . ILE A 1 4   ? 9.411   3.613   49.050 1.00 22.93  ? 27  ILE A CA  1 ? 
ATOM   10   C C   . ILE A 1 4   ? 9.750   3.294   47.586 1.00 23.27  ? 27  ILE A C   1 ? 
ATOM   11   O O   . ILE A 1 4   ? 10.924  3.286   47.250 1.00 26.99  ? 27  ILE A O   1 ? 
ATOM   12   C CB  . ILE A 1 4   ? 9.792   5.061   49.401 1.00 24.63  ? 27  ILE A CB  1 ? 
ATOM   13   C CG1 . ILE A 1 4   ? 9.465   5.386   50.851 1.00 21.85  ? 27  ILE A CG1 1 ? 
ATOM   14   C CG2 . ILE A 1 4   ? 9.140   6.049   48.437 1.00 22.26  ? 27  ILE A CG2 1 ? 
ATOM   15   C CD1 . ILE A 1 4   ? 10.236  6.566   51.406 1.00 21.92  ? 27  ILE A CD1 1 ? 
ATOM   16   N N   . VAL A 1 5   ? 8.740   3.053   46.769 1.00 21.27  ? 28  VAL A N   1 ? 
ATOM   17   C CA  . VAL A 1 5   ? 8.961   2.723   45.334 1.00 21.17  ? 28  VAL A CA  1 ? 
ATOM   18   C C   . VAL A 1 5   ? 8.789   3.980   44.470 1.00 19.22  ? 28  VAL A C   1 ? 
ATOM   19   O O   . VAL A 1 5   ? 7.846   4.728   44.685 1.00 25.77  ? 28  VAL A O   1 ? 
ATOM   20   C CB  . VAL A 1 5   ? 8.076   1.569   44.817 1.00 22.00  ? 28  VAL A CB  1 ? 
ATOM   21   C CG1 . VAL A 1 5   ? 8.216   1.366   43.316 1.00 18.29  ? 28  VAL A CG1 1 ? 
ATOM   22   C CG2 . VAL A 1 5   ? 8.362   0.273   45.563 1.00 18.90  ? 28  VAL A CG2 1 ? 
ATOM   23   N N   . ILE A 1 6   ? 9.725   4.196   43.566 1.00 19.92  ? 29  ILE A N   1 ? 
ATOM   24   C CA  . ILE A 1 6   ? 9.609   5.316   42.601 1.00 16.90  ? 29  ILE A CA  1 ? 
ATOM   25   C C   . ILE A 1 6   ? 9.589   4.685   41.200 1.00 17.17  ? 29  ILE A C   1 ? 
ATOM   26   O O   . ILE A 1 6   ? 10.605  4.094   40.812 1.00 15.98  ? 29  ILE A O   1 ? 
ATOM   27   C CB  . ILE A 1 6   ? 10.763  6.323   42.722 1.00 17.72  ? 29  ILE A CB  1 ? 
ATOM   28   C CG1 . ILE A 1 6   ? 10.784  7.010   44.077 1.00 15.03  ? 29  ILE A CG1 1 ? 
ATOM   29   C CG2 . ILE A 1 6   ? 10.713  7.339   41.580 1.00 15.22  ? 29  ILE A CG2 1 ? 
ATOM   30   C CD1 . ILE A 1 6   ? 11.870  8.060   44.202 1.00 18.51  ? 29  ILE A CD1 1 ? 
ATOM   31   N N   . LYS A 1 7   ? 8.455   4.784   40.521 1.00 14.40  ? 30  LYS A N   1 ? 
ATOM   32   C CA  . LYS A 1 7   ? 8.355   4.287   39.133 1.00 15.67  ? 30  LYS A CA  1 ? 
ATOM   33   C C   . LYS A 1 7   ? 8.671   5.471   38.210 1.00 15.87  ? 30  LYS A C   1 ? 
ATOM   34   O O   . LYS A 1 7   ? 8.050   6.521   38.383 1.00 20.08  ? 30  LYS A O   1 ? 
ATOM   35   C CB  . LYS A 1 7   ? 7.013   3.590   38.887 1.00 20.23  ? 30  LYS A CB  1 ? 
ATOM   36   C CG  . LYS A 1 7   ? 6.693   2.390   39.759 1.00 17.41  ? 30  LYS A CG  1 ? 
ATOM   37   C CD  . LYS A 1 7   ? 5.376   1.743   39.355 1.00 25.32  ? 30  LYS A CD  1 ? 
ATOM   38   C CE  . LYS A 1 7   ? 5.145   0.388   39.953 1.00 31.38  ? 30  LYS A CE  1 ? 
ATOM   39   N NZ  . LYS A 1 7   ? 6.290   -0.516  39.827 1.00 32.64  ? 30  LYS A NZ  1 ? 
ATOM   40   N N   . PHE A 1 8   ? 9.643   5.284   37.328 1.00 16.64  ? 31  PHE A N   1 ? 
ATOM   41   C CA  . PHE A 1 8   ? 10.103  6.352   36.417 1.00 14.63  ? 31  PHE A CA  1 ? 
ATOM   42   C C   . PHE A 1 8   ? 9.824   5.859   35.012 1.00 14.97  ? 31  PHE A C   1 ? 
ATOM   43   O O   . PHE A 1 8   ? 10.490  4.924   34.583 1.00 15.79  ? 31  PHE A O   1 ? 
ATOM   44   C CB  . PHE A 1 8   ? 11.580  6.645   36.697 1.00 14.19  ? 31  PHE A CB  1 ? 
ATOM   45   C CG  . PHE A 1 8   ? 12.189  7.885   36.054 1.00 15.91  ? 31  PHE A CG  1 ? 
ATOM   46   C CD1 . PHE A 1 8   ? 11.574  8.527   34.988 1.00 14.44  ? 31  PHE A CD1 1 ? 
ATOM   47   C CD2 . PHE A 1 8   ? 13.388  8.408   36.521 1.00 17.34  ? 31  PHE A CD2 1 ? 
ATOM   48   C CE1 . PHE A 1 8   ? 12.138  9.652   34.414 1.00 16.77  ? 31  PHE A CE1 1 ? 
ATOM   49   C CE2 . PHE A 1 8   ? 13.946  9.538   35.944 1.00 17.29  ? 31  PHE A CE2 1 ? 
ATOM   50   C CZ  . PHE A 1 8   ? 13.321  10.156  34.892 1.00 15.21  ? 31  PHE A CZ  1 ? 
ATOM   51   N N   . SER A 1 9   ? 8.861   6.487   34.351 1.00 15.38  ? 32  SER A N   1 ? 
ATOM   52   C CA  . SER A 1 9   ? 8.454   6.110   32.980 1.00 13.55  ? 32  SER A CA  1 ? 
ATOM   53   C C   . SER A 1 9   ? 8.981   7.140   31.974 1.00 14.25  ? 32  SER A C   1 ? 
ATOM   54   O O   . SER A 1 9   ? 9.021   8.321   32.314 1.00 12.49  ? 32  SER A O   1 ? 
ATOM   55   C CB  . SER A 1 9   ? 6.944   6.048   32.855 1.00 12.71  ? 32  SER A CB  1 ? 
ATOM   56   O OG  . SER A 1 9   ? 6.546   5.513   31.607 1.00 28.04  ? 32  SER A OG  1 ? 
ATOM   57   N N   . HIS A 1 10  ? 9.296   6.675   30.765 1.00 13.43  ? 33  HIS A N   1 ? 
ATOM   58   C CA  . HIS A 1 10  ? 9.680   7.632   29.702 1.00 16.02  ? 33  HIS A CA  1 ? 
ATOM   59   C C   . HIS A 1 10  ? 9.420   7.021   28.323 1.00 14.95  ? 33  HIS A C   1 ? 
ATOM   60   O O   . HIS A 1 10  ? 9.143   5.829   28.242 1.00 18.38  ? 33  HIS A O   1 ? 
ATOM   61   C CB  . HIS A 1 10  ? 11.103  8.152   29.913 1.00 13.68  ? 33  HIS A CB  1 ? 
ATOM   62   C CG  . HIS A 1 10  ? 12.194  7.152   29.775 1.00 17.01  ? 33  HIS A CG  1 ? 
ATOM   63   N ND1 . HIS A 1 10  ? 12.699  6.744   28.562 1.00 16.41  ? 33  HIS A ND1 1 ? 
ATOM   64   C CD2 . HIS A 1 10  ? 12.901  6.515   30.705 1.00 15.85  ? 33  HIS A CD2 1 ? 
ATOM   65   C CE1 . HIS A 1 10  ? 13.671  5.875   28.772 1.00 20.23  ? 33  HIS A CE1 1 ? 
ATOM   66   N NE2 . HIS A 1 10  ? 13.806  5.719   30.066 1.00 19.39  ? 33  HIS A NE2 1 ? 
ATOM   67   N N   . VAL A 1 11  ? 9.541   7.843   27.288 1.00 15.16  ? 34  VAL A N   1 ? 
ATOM   68   C CA  . VAL A 1 11  ? 9.194   7.395   25.911 1.00 15.31  ? 34  VAL A CA  1 ? 
ATOM   69   C C   . VAL A 1 11  ? 10.429  7.167   25.023 1.00 18.89  ? 34  VAL A C   1 ? 
ATOM   70   O O   . VAL A 1 11  ? 10.242  6.863   23.852 1.00 19.90  ? 34  VAL A O   1 ? 
ATOM   71   C CB  . VAL A 1 11  ? 8.269   8.463   25.303 1.00 14.33  ? 34  VAL A CB  1 ? 
ATOM   72   C CG1 . VAL A 1 11  ? 7.003   8.645   26.126 1.00 16.11  ? 34  VAL A CG1 1 ? 
ATOM   73   C CG2 . VAL A 1 11  ? 8.984   9.789   25.087 1.00 11.09  ? 34  VAL A CG2 1 ? 
ATOM   74   N N   . VAL A 1 12  ? 11.634  7.322   25.559 1.00 17.39  ? 35  VAL A N   1 ? 
ATOM   75   C CA  . VAL A 1 12  ? 12.831  7.223   24.680 1.00 14.34  ? 35  VAL A CA  1 ? 
ATOM   76   C C   . VAL A 1 12  ? 13.533  5.865   24.827 1.00 16.75  ? 35  VAL A C   1 ? 
ATOM   77   O O   . VAL A 1 12  ? 13.209  5.113   25.742 1.00 14.74  ? 35  VAL A O   1 ? 
ATOM   78   C CB  . VAL A 1 12  ? 13.824  8.371   24.936 1.00 13.91  ? 35  VAL A CB  1 ? 
ATOM   79   C CG1 . VAL A 1 12  ? 13.224  9.727   24.613 1.00 16.26  ? 35  VAL A CG1 1 ? 
ATOM   80   C CG2 . VAL A 1 12  ? 14.407  8.340   26.339 1.00 13.52  ? 35  VAL A CG2 1 ? 
ATOM   81   N N   . ALA A 1 13  ? 14.431  5.582   23.895 1.00 14.01  ? 36  ALA A N   1 ? 
ATOM   82   C CA  . ALA A 1 13  ? 15.242  4.353   23.978 1.00 14.30  ? 36  ALA A CA  1 ? 
ATOM   83   C C   . ALA A 1 13  ? 16.178  4.438   25.187 1.00 16.07  ? 36  ALA A C   1 ? 
ATOM   84   O O   . ALA A 1 13  ? 16.500  5.521   25.662 1.00 15.68  ? 36  ALA A O   1 ? 
ATOM   85   C CB  . ALA A 1 13  ? 16.026  4.208   22.713 1.00 12.54  ? 36  ALA A CB  1 ? 
ATOM   86   N N   . GLU A 1 14  ? 16.659  3.289   25.633 1.00 15.28  ? 37  GLU A N   1 ? 
ATOM   87   C CA  . GLU A 1 14  ? 17.583  3.284   26.793 1.00 16.01  ? 37  GLU A CA  1 ? 
ATOM   88   C C   . GLU A 1 14  ? 18.906  3.971   26.424 1.00 17.31  ? 37  GLU A C   1 ? 
ATOM   89   O O   . GLU A 1 14  ? 19.489  4.610   27.290 1.00 20.25  ? 37  GLU A O   1 ? 
ATOM   90   C CB  . GLU A 1 14  ? 17.847  1.857   27.261 1.00 16.40  ? 37  GLU A CB  1 ? 
ATOM   91   C CG  . GLU A 1 14  ? 16.612  1.142   27.791 1.00 23.71  ? 37  GLU A CG  1 ? 
ATOM   92   C CD  . GLU A 1 14  ? 17.009  -0.170  28.435 1.00 30.02  ? 37  GLU A CD  1 ? 
ATOM   93   O OE1 . GLU A 1 14  ? 16.397  -0.555  29.438 1.00 27.31  ? 37  GLU A OE1 1 ? 
ATOM   94   O OE2 . GLU A 1 14  ? 17.951  -0.800  27.926 1.00 39.60  ? 37  GLU A OE2 1 ? 
ATOM   95   N N   . ASN A 1 15  ? 19.359  3.813   25.186 1.00 17.14  ? 38  ASN A N   1 ? 
ATOM   96   C CA  . ASN A 1 15  ? 20.683  4.344   24.760 1.00 18.37  ? 38  ASN A CA  1 ? 
ATOM   97   C C   . ASN A 1 15  ? 20.580  5.831   24.420 1.00 16.00  ? 38  ASN A C   1 ? 
ATOM   98   O O   . ASN A 1 15  ? 20.974  6.204   23.320 1.00 19.76  ? 38  ASN A O   1 ? 
ATOM   99   C CB  . ASN A 1 15  ? 21.240  3.496   23.627 1.00 20.39  ? 38  ASN A CB  1 ? 
ATOM   100  C CG  . ASN A 1 15  ? 20.340  3.418   22.420 1.00 26.85  ? 38  ASN A CG  1 ? 
ATOM   101  O OD1 . ASN A 1 15  ? 19.122  3.295   22.553 1.00 29.17  ? 38  ASN A OD1 1 ? 
ATOM   102  N ND2 . ASN A 1 15  ? 20.928  3.467   21.236 1.00 28.65  ? 38  ASN A ND2 1 ? 
ATOM   103  N N   . THR A 1 16  ? 20.076  6.623   25.353 1.00 16.14  ? 39  THR A N   1 ? 
ATOM   104  C CA  . THR A 1 16  ? 19.832  8.060   25.126 1.00 15.00  ? 39  THR A CA  1 ? 
ATOM   105  C C   . THR A 1 16  ? 20.170  8.831   26.382 1.00 14.03  ? 39  THR A C   1 ? 
ATOM   106  O O   . THR A 1 16  ? 20.292  8.223   27.431 1.00 15.10  ? 39  THR A O   1 ? 
ATOM   107  C CB  . THR A 1 16  ? 18.345  8.237   24.808 1.00 13.90  ? 39  THR A CB  1 ? 
ATOM   108  O OG1 . THR A 1 16  ? 17.630  7.784   25.952 1.00 15.20  ? 39  THR A OG1 1 ? 
ATOM   109  C CG2 . THR A 1 16  ? 17.909  7.509   23.548 1.00 13.44  ? 39  THR A CG2 1 ? 
ATOM   110  N N   . PRO A 1 17  ? 20.269  10.167  26.319 1.00 13.21  ? 40  PRO A N   1 ? 
ATOM   111  C CA  . PRO A 1 17  ? 20.475  10.941  27.532 1.00 13.87  ? 40  PRO A CA  1 ? 
ATOM   112  C C   . PRO A 1 17  ? 19.480  10.591  28.651 1.00 15.76  ? 40  PRO A C   1 ? 
ATOM   113  O O   . PRO A 1 17  ? 19.894  10.224  29.758 1.00 14.22  ? 40  PRO A O   1 ? 
ATOM   114  C CB  . PRO A 1 17  ? 20.294  12.384  27.013 1.00 17.33  ? 40  PRO A CB  1 ? 
ATOM   115  C CG  . PRO A 1 17  ? 20.680  12.321  25.561 1.00 17.75  ? 40  PRO A CG  1 ? 
ATOM   116  C CD  . PRO A 1 17  ? 20.242  10.954  25.100 1.00 14.38  ? 40  PRO A CD  1 ? 
ATOM   117  N N   . LYS A 1 18  ? 18.183  10.679  28.356 1.00 13.93  ? 41  LYS A N   1 ? 
ATOM   118  C CA  . LYS A 1 18  ? 17.138  10.433  29.388 1.00 12.71  ? 41  LYS A CA  1 ? 
ATOM   119  C C   . LYS A 1 18  ? 17.131  8.950   29.815 1.00 13.87  ? 41  LYS A C   1 ? 
ATOM   120  O O   . LYS A 1 18  ? 17.004  8.660   30.994 1.00 11.96  ? 41  LYS A O   1 ? 
ATOM   121  C CB  . LYS A 1 18  ? 15.759  10.863  28.880 1.00 12.39  ? 41  LYS A CB  1 ? 
ATOM   122  C CG  . LYS A 1 18  ? 14.583  10.533  29.782 1.00 13.06  ? 41  LYS A CG  1 ? 
ATOM   123  C CD  . LYS A 1 18  ? 13.360  11.397  29.508 1.00 11.58  ? 41  LYS A CD  1 ? 
ATOM   124  C CE  . LYS A 1 18  ? 12.829  11.254  28.120 1.00 11.13  ? 41  LYS A CE  1 ? 
ATOM   125  N NZ  . LYS A 1 18  ? 11.689  12.131  27.860 1.00 12.38  ? 41  LYS A NZ  1 ? 
ATOM   126  N N   . GLY A 1 19  ? 17.298  8.060   28.851 1.00 15.81  ? 42  GLY A N   1 ? 
ATOM   127  C CA  . GLY A 1 19  ? 17.267  6.622   29.185 1.00 17.64  ? 42  GLY A CA  1 ? 
ATOM   128  C C   . GLY A 1 19  ? 18.386  6.245   30.134 1.00 16.10  ? 42  GLY A C   1 ? 
ATOM   129  O O   . GLY A 1 19  ? 18.124  5.552   31.113 1.00 13.82  ? 42  GLY A O   1 ? 
ATOM   130  N N   . GLN A 1 20  ? 19.595  6.707   29.831 1.00 18.72  ? 43  GLN A N   1 ? 
ATOM   131  C CA  . GLN A 1 20  ? 20.746  6.477   30.734 1.00 17.28  ? 43  GLN A CA  1 ? 
ATOM   132  C C   . GLN A 1 20  ? 20.508  7.206   32.074 1.00 18.42  ? 43  GLN A C   1 ? 
ATOM   133  O O   . GLN A 1 20  ? 20.826  6.645   33.114 1.00 17.85  ? 43  GLN A O   1 ? 
ATOM   134  C CB  . GLN A 1 20  ? 22.025  6.961   30.051 1.00 18.96  ? 43  GLN A CB  1 ? 
ATOM   135  C CG  . GLN A 1 20  ? 22.388  6.177   28.800 1.00 20.43  ? 43  GLN A CG  1 ? 
ATOM   136  C CD  . GLN A 1 20  ? 22.663  4.725   29.108 1.00 30.16  ? 43  GLN A CD  1 ? 
ATOM   137  O OE1 . GLN A 1 20  ? 21.902  3.828   28.734 1.00 35.08  ? 43  GLN A OE1 1 ? 
ATOM   138  N NE2 . GLN A 1 20  ? 23.750  4.487   29.825 1.00 26.59  ? 43  GLN A NE2 1 ? 
ATOM   139  N N   . GLY A 1 21  ? 19.956  8.415   32.029 1.00 15.54  ? 44  GLY A N   1 ? 
ATOM   140  C CA  . GLY A 1 21  ? 19.723  9.187   33.261 1.00 15.05  ? 44  GLY A CA  1 ? 
ATOM   141  C C   . GLY A 1 21  ? 18.813  8.442   34.222 1.00 13.50  ? 44  GLY A C   1 ? 
ATOM   142  O O   . GLY A 1 21  ? 19.125  8.364   35.413 1.00 13.79  ? 44  GLY A O   1 ? 
ATOM   143  N N   . ALA A 1 22  ? 17.718  7.910   33.698 1.00 12.68  ? 45  ALA A N   1 ? 
ATOM   144  C CA  . ALA A 1 22  ? 16.751  7.190   34.553 1.00 13.18  ? 45  ALA A CA  1 ? 
ATOM   145  C C   . ALA A 1 22  ? 17.431  5.966   35.173 1.00 12.58  ? 45  ALA A C   1 ? 
ATOM   146  O O   . ALA A 1 22  ? 17.251  5.685   36.343 1.00 13.82  ? 45  ALA A O   1 ? 
ATOM   147  C CB  . ALA A 1 22  ? 15.552  6.810   33.740 1.00 12.76  ? 45  ALA A CB  1 ? 
ATOM   148  N N   . LEU A 1 23  ? 18.227  5.277   34.361 1.00 16.80  ? 46  LEU A N   1 ? 
ATOM   149  C CA  . LEU A 1 23  ? 18.919  4.050   34.854 1.00 15.78  ? 46  LEU A CA  1 ? 
ATOM   150  C C   . LEU A 1 23  ? 20.010  4.418   35.882 1.00 14.62  ? 46  LEU A C   1 ? 
ATOM   151  O O   . LEU A 1 23  ? 20.209  3.651   36.813 1.00 15.90  ? 46  LEU A O   1 ? 
ATOM   152  C CB  . LEU A 1 23  ? 19.478  3.273   33.668 1.00 16.13  ? 46  LEU A CB  1 ? 
ATOM   153  C CG  . LEU A 1 23  ? 18.463  2.501   32.826 1.00 17.88  ? 46  LEU A CG  1 ? 
ATOM   154  C CD1 . LEU A 1 23  ? 19.071  2.150   31.485 1.00 18.30  ? 46  LEU A CD1 1 ? 
ATOM   155  C CD2 . LEU A 1 23  ? 18.058  1.256   33.576 1.00 21.32  ? 46  LEU A CD2 1 ? 
ATOM   156  N N   . LEU A 1 24  ? 20.680  5.555   35.706 1.00 13.09  ? 47  LEU A N   1 ? 
ATOM   157  C CA  . LEU A 1 24  ? 21.689  6.029   36.693 1.00 13.26  ? 47  LEU A CA  1 ? 
ATOM   158  C C   . LEU A 1 24  ? 21.001  6.395   38.017 1.00 12.48  ? 47  LEU A C   1 ? 
ATOM   159  O O   . LEU A 1 24  ? 21.519  6.057   39.067 1.00 13.07  ? 47  LEU A O   1 ? 
ATOM   160  C CB  . LEU A 1 24  ? 22.474  7.232   36.183 1.00 14.79  ? 47  LEU A CB  1 ? 
ATOM   161  C CG  . LEU A 1 24  ? 23.649  7.656   37.068 1.00 17.28  ? 47  LEU A CG  1 ? 
ATOM   162  C CD1 . LEU A 1 24  ? 24.541  6.470   37.373 1.00 14.03  ? 47  LEU A CD1 1 ? 
ATOM   163  C CD2 . LEU A 1 24  ? 24.452  8.783   36.461 1.00 16.16  ? 47  LEU A CD2 1 ? 
ATOM   164  N N   . PHE A 1 25  ? 19.850  7.056   37.918 1.00 12.45  ? 48  PHE A N   1 ? 
ATOM   165  C CA  . PHE A 1 25  ? 19.108  7.448   39.143 1.00 13.20  ? 48  PHE A CA  1 ? 
ATOM   166  C C   . PHE A 1 25  ? 18.817  6.173   39.940 1.00 13.89  ? 48  PHE A C   1 ? 
ATOM   167  O O   . PHE A 1 25  ? 19.037  6.109   41.141 1.00 15.32  ? 48  PHE A O   1 ? 
ATOM   168  C CB  . PHE A 1 25  ? 17.840  8.228   38.792 1.00 11.95  ? 48  PHE A CB  1 ? 
ATOM   169  C CG  . PHE A 1 25  ? 17.072  8.746   40.000 1.00 14.65  ? 48  PHE A CG  1 ? 
ATOM   170  C CD1 . PHE A 1 25  ? 17.599  9.753   40.796 1.00 12.70  ? 48  PHE A CD1 1 ? 
ATOM   171  C CD2 . PHE A 1 25  ? 15.830  8.227   40.338 1.00 13.40  ? 48  PHE A CD2 1 ? 
ATOM   172  C CE1 . PHE A 1 25  ? 16.909  10.218  41.901 1.00 13.71  ? 48  PHE A CE1 1 ? 
ATOM   173  C CE2 . PHE A 1 25  ? 15.145  8.698   41.444 1.00 14.18  ? 48  PHE A CE2 1 ? 
ATOM   174  C CZ  . PHE A 1 25  ? 15.684  9.694   42.220 1.00 12.84  ? 48  PHE A CZ  1 ? 
ATOM   175  N N   . LYS A 1 26  ? 18.353  5.152   39.233 1.00 15.93  ? 49  LYS A N   1 ? 
ATOM   176  C CA  . LYS A 1 26  ? 18.010  3.872   39.900 1.00 14.88  ? 49  LYS A CA  1 ? 
ATOM   177  C C   . LYS A 1 26  ? 19.258  3.276   40.565 1.00 12.65  ? 49  LYS A C   1 ? 
ATOM   178  O O   . LYS A 1 26  ? 19.178  2.874   41.720 1.00 17.30  ? 49  LYS A O   1 ? 
ATOM   179  C CB  . LYS A 1 26  ? 17.461  2.919   38.840 1.00 16.03  ? 49  LYS A CB  1 ? 
ATOM   180  C CG  . LYS A 1 26  ? 17.185  1.496   39.277 1.00 14.81  ? 49  LYS A CG  1 ? 
ATOM   181  C CD  . LYS A 1 26  ? 16.627  0.677   38.124 1.00 14.75  ? 49  LYS A CD  1 ? 
ATOM   182  C CE  . LYS A 1 26  ? 16.629  -0.783  38.420 1.00 17.48  ? 49  LYS A CE  1 ? 
ATOM   183  N NZ  . LYS A 1 26  ? 15.726  -1.065  39.531 1.00 21.57  ? 49  LYS A NZ  1 ? 
ATOM   184  N N   . LYS A 1 27  ? 20.374  3.273   39.856 1.00 17.76  ? 50  LYS A N   1 ? 
ATOM   185  C CA  . LYS A 1 27  ? 21.640  2.690   40.374 1.00 13.52  ? 50  LYS A CA  1 ? 
ATOM   186  C C   . LYS A 1 27  ? 22.117  3.423   41.631 1.00 15.55  ? 50  LYS A C   1 ? 
ATOM   187  O O   . LYS A 1 27  ? 22.399  2.767   42.625 1.00 20.46  ? 50  LYS A O   1 ? 
ATOM   188  C CB  . LYS A 1 27  ? 22.688  2.816   39.274 1.00 15.50  ? 50  LYS A CB  1 ? 
ATOM   189  C CG  . LYS A 1 27  ? 24.088  2.429   39.667 1.00 20.65  ? 50  LYS A CG  1 ? 
ATOM   190  C CD  . LYS A 1 27  ? 24.919  2.219   38.414 1.00 25.53  ? 50  LYS A CD  1 ? 
ATOM   191  C CE  . LYS A 1 27  ? 26.360  2.311   38.727 1.00 29.12  ? 50  LYS A CE  1 ? 
ATOM   192  N NZ  . LYS A 1 27  ? 27.152  2.449   37.505 1.00 34.29  ? 50  LYS A NZ  1 ? 
ATOM   193  N N   . LEU A 1 28  ? 22.162  4.748   41.563 1.00 15.21  ? 51  LEU A N   1 ? 
ATOM   194  C CA  . LEU A 1 28  ? 22.664  5.555   42.704 1.00 14.98  ? 51  LEU A CA  1 ? 
ATOM   195  C C   . LEU A 1 28  ? 21.721  5.420   43.913 1.00 14.28  ? 51  LEU A C   1 ? 
ATOM   196  O O   . LEU A 1 28  ? 22.225  5.309   45.028 1.00 15.91  ? 51  LEU A O   1 ? 
ATOM   197  C CB  . LEU A 1 28  ? 22.862  7.005   42.272 1.00 12.44  ? 51  LEU A CB  1 ? 
ATOM   198  C CG  . LEU A 1 28  ? 23.909  7.263   41.187 1.00 15.39  ? 51  LEU A CG  1 ? 
ATOM   199  C CD1 . LEU A 1 28  ? 24.187  8.750   41.075 1.00 13.14  ? 51  LEU A CD1 1 ? 
ATOM   200  C CD2 . LEU A 1 28  ? 25.186  6.489   41.438 1.00 12.71  ? 51  LEU A CD2 1 ? 
ATOM   201  N N   . VAL A 1 29  ? 20.412  5.397   43.678 1.00 14.08  ? 52  VAL A N   1 ? 
ATOM   202  C CA  . VAL A 1 29  ? 19.454  5.168   44.802 1.00 15.80  ? 52  VAL A CA  1 ? 
ATOM   203  C C   . VAL A 1 29  ? 19.767  3.798   45.434 1.00 15.11  ? 52  VAL A C   1 ? 
ATOM   204  O O   . VAL A 1 29  ? 19.860  3.712   46.648 1.00 17.97  ? 52  VAL A O   1 ? 
ATOM   205  C CB  . VAL A 1 29  ? 17.972  5.281   44.395 1.00 15.47  ? 52  VAL A CB  1 ? 
ATOM   206  C CG1 . VAL A 1 29  ? 17.037  4.787   45.487 1.00 14.85  ? 52  VAL A CG1 1 ? 
ATOM   207  C CG2 . VAL A 1 29  ? 17.616  6.707   44.005 1.00 14.00  ? 52  VAL A CG2 1 ? 
ATOM   208  N N   . GLU A 1 30  ? 19.939  2.789   44.599 1.00 14.23  ? 53  GLU A N   1 ? 
ATOM   209  C CA  . GLU A 1 30  ? 20.288  1.446   45.122 1.00 14.32  ? 53  GLU A CA  1 ? 
ATOM   210  C C   . GLU A 1 30  ? 21.612  1.485   45.907 1.00 18.70  ? 53  GLU A C   1 ? 
ATOM   211  O O   . GLU A 1 30  ? 21.692  0.848   46.956 1.00 17.73  ? 53  GLU A O   1 ? 
ATOM   212  C CB  . GLU A 1 30  ? 20.330  0.490   43.939 1.00 15.30  ? 53  GLU A CB  1 ? 
ATOM   213  C CG  . GLU A 1 30  ? 18.946  0.186   43.383 1.00 17.76  ? 53  GLU A CG  1 ? 
ATOM   214  C CD  . GLU A 1 30  ? 18.943  -0.587  42.082 1.00 19.65  ? 53  GLU A CD  1 ? 
ATOM   215  O OE1 . GLU A 1 30  ? 17.839  -0.953  41.656 1.00 22.31  ? 53  GLU A OE1 1 ? 
ATOM   216  O OE2 . GLU A 1 30  ? 20.022  -0.823  41.510 1.00 24.32  ? 53  GLU A OE2 1 ? 
ATOM   217  N N   . GLN A 1 31  ? 22.592  2.236   45.422 1.00 15.31  ? 54  GLN A N   1 ? 
ATOM   218  C CA  . GLN A 1 31  ? 23.926  2.258   46.057 1.00 19.56  ? 54  GLN A CA  1 ? 
ATOM   219  C C   . GLN A 1 31  ? 23.970  3.136   47.314 1.00 21.65  ? 54  GLN A C   1 ? 
ATOM   220  O O   . GLN A 1 31  ? 24.845  2.904   48.143 1.00 18.52  ? 54  GLN A O   1 ? 
ATOM   221  C CB  . GLN A 1 31  ? 24.905  2.835   45.043 1.00 21.18  ? 54  GLN A CB  1 ? 
ATOM   222  C CG  . GLN A 1 31  ? 25.211  1.903   43.879 1.00 14.78  ? 54  GLN A CG  1 ? 
ATOM   223  C CD  . GLN A 1 31  ? 26.401  2.350   43.063 1.00 14.33  ? 54  GLN A CD  1 ? 
ATOM   224  O OE1 . GLN A 1 31  ? 26.880  3.480   43.186 1.00 16.97  ? 54  GLN A OE1 1 ? 
ATOM   225  N NE2 . GLN A 1 31  ? 26.893  1.456   42.222 1.00 13.96  ? 54  GLN A NE2 1 ? 
ATOM   226  N N   . ARG A 1 32  ? 23.044  4.078   47.447 1.00 20.39  ? 55  ARG A N   1 ? 
ATOM   227  C CA  . ARG A 1 32  ? 23.157  5.067   48.549 1.00 20.41  ? 55  ARG A CA  1 ? 
ATOM   228  C C   . ARG A 1 32  ? 21.999  5.075   49.571 1.00 21.08  ? 55  ARG A C   1 ? 
ATOM   229  O O   . ARG A 1 32  ? 22.212  5.615   50.649 1.00 21.97  ? 55  ARG A O   1 ? 
ATOM   230  C CB  . ARG A 1 32  ? 23.261  6.429   47.859 1.00 16.64  ? 55  ARG A CB  1 ? 
ATOM   231  C CG  . ARG A 1 32  ? 24.546  6.659   47.084 1.00 21.59  ? 55  ARG A CG  1 ? 
ATOM   232  C CD  . ARG A 1 32  ? 24.414  7.869   46.186 1.00 18.33  ? 55  ARG A CD  1 ? 
ATOM   233  N NE  . ARG A 1 32  ? 25.607  8.058   45.359 1.00 20.83  ? 55  ARG A NE  1 ? 
ATOM   234  C CZ  . ARG A 1 32  ? 25.936  9.219   44.821 1.00 21.55  ? 55  ARG A CZ  1 ? 
ATOM   235  N NH1 . ARG A 1 32  ? 25.307  10.312  45.199 1.00 18.62  ? 55  ARG A NH1 1 ? 
ATOM   236  N NH2 . ARG A 1 32  ? 26.888  9.282   43.912 1.00 18.61  ? 55  ARG A NH2 1 ? 
ATOM   237  N N   . LEU A 1 33  ? 20.833  4.520   49.250 1.00 20.38  ? 56  LEU A N   1 ? 
ATOM   238  C CA  . LEU A 1 33  ? 19.696  4.659   50.204 1.00 20.15  ? 56  LEU A CA  1 ? 
ATOM   239  C C   . LEU A 1 33  ? 19.408  3.367   51.002 1.00 21.21  ? 56  LEU A C   1 ? 
ATOM   240  O O   . LEU A 1 33  ? 18.387  3.329   51.677 1.00 22.15  ? 56  LEU A O   1 ? 
ATOM   241  C CB  . LEU A 1 33  ? 18.472  5.250   49.502 1.00 20.75  ? 56  LEU A CB  1 ? 
ATOM   242  C CG  . LEU A 1 33  ? 18.499  6.778   49.430 1.00 25.03  ? 56  LEU A CG  1 ? 
ATOM   243  C CD1 . LEU A 1 33  ? 17.777  7.336   48.240 1.00 25.01  ? 56  LEU A CD1 1 ? 
ATOM   244  C CD2 . LEU A 1 33  ? 18.014  7.411   50.719 1.00 20.70  ? 56  LEU A CD2 1 ? 
ATOM   245  N N   . GLY A 1 34  ? 20.281  2.371   50.934 1.00 18.12  ? 57  GLY A N   1 ? 
ATOM   246  C CA  . GLY A 1 34  ? 20.152  1.176   51.787 1.00 20.95  ? 57  GLY A CA  1 ? 
ATOM   247  C C   . GLY A 1 34  ? 18.812  0.473   51.720 1.00 25.53  ? 57  GLY A C   1 ? 
ATOM   248  O O   . GLY A 1 34  ? 18.414  -0.105  52.736 1.00 29.83  ? 57  GLY A O   1 ? 
ATOM   249  N N   . GLY A 1 35  ? 18.140  0.516   50.578 1.00 22.25  ? 58  GLY A N   1 ? 
ATOM   250  C CA  . GLY A 1 35  ? 16.866  -0.201  50.416 1.00 21.76  ? 58  GLY A CA  1 ? 
ATOM   251  C C   . GLY A 1 35  ? 15.657  0.569   50.912 1.00 22.85  ? 58  GLY A C   1 ? 
ATOM   252  O O   . GLY A 1 35  ? 14.551  0.057   50.759 1.00 23.71  ? 58  GLY A O   1 ? 
ATOM   253  N N   . ARG A 1 36  ? 15.864  1.765   51.468 1.00 20.19  ? 59  ARG A N   1 ? 
ATOM   254  C CA  . ARG A 1 36  ? 14.732  2.607   51.917 1.00 24.69  ? 59  ARG A CA  1 ? 
ATOM   255  C C   . ARG A 1 36  ? 13.924  3.105   50.702 1.00 25.13  ? 59  ARG A C   1 ? 
ATOM   256  O O   . ARG A 1 36  ? 12.728  3.361   50.848 1.00 26.38  ? 59  ARG A O   1 ? 
ATOM   257  C CB  . ARG A 1 36  ? 15.266  3.753   52.772 1.00 24.10  ? 59  ARG A CB  1 ? 
ATOM   258  C CG  . ARG A 1 36  ? 16.153  3.369   53.943 1.00 25.62  ? 59  ARG A CG  1 ? 
ATOM   259  C CD  . ARG A 1 36  ? 16.791  4.632   54.484 1.00 32.99  ? 59  ARG A CD  1 ? 
ATOM   260  N NE  . ARG A 1 36  ? 15.832  5.321   55.349 1.00 44.90  ? 59  ARG A NE  1 ? 
ATOM   261  C CZ  . ARG A 1 36  ? 15.883  6.602   55.683 1.00 57.99  ? 59  ARG A CZ  1 ? 
ATOM   262  N NH1 . ARG A 1 36  ? 16.926  7.333   55.338 1.00 49.55  ? 59  ARG A NH1 1 ? 
ATOM   263  N NH2 . ARG A 1 36  ? 14.888  7.144   56.360 1.00 48.90  ? 59  ARG A NH2 1 ? 
ATOM   264  N N   . VAL A 1 37  ? 14.584  3.238   49.564 1.00 21.85  ? 60  VAL A N   1 ? 
ATOM   265  C CA  . VAL A 1 37  ? 13.886  3.632   48.315 1.00 19.86  ? 60  VAL A CA  1 ? 
ATOM   266  C C   . VAL A 1 37  ? 14.274  2.626   47.224 1.00 19.87  ? 60  VAL A C   1 ? 
ATOM   267  O O   . VAL A 1 37  ? 15.446  2.237   47.164 1.00 20.74  ? 60  VAL A O   1 ? 
ATOM   268  C CB  . VAL A 1 37  ? 14.190  5.075   47.866 1.00 19.24  ? 60  VAL A CB  1 ? 
ATOM   269  C CG1 . VAL A 1 37  ? 13.461  5.477   46.591 1.00 16.65  ? 60  VAL A CG1 1 ? 
ATOM   270  C CG2 . VAL A 1 37  ? 13.966  6.089   48.975 1.00 18.63  ? 60  VAL A CG2 1 ? 
ATOM   271  N N   . GLU A 1 38  ? 13.306  2.231   46.420 1.00 22.12  ? 61  GLU A N   1 ? 
ATOM   272  C CA  . GLU A 1 38  ? 13.578  1.369   45.251 1.00 19.48  ? 61  GLU A CA  1 ? 
ATOM   273  C C   . GLU A 1 38  ? 13.091  2.123   44.009 1.00 18.37  ? 61  GLU A C   1 ? 
ATOM   274  O O   . GLU A 1 38  ? 12.170  2.928   44.138 1.00 22.99  ? 61  GLU A O   1 ? 
ATOM   275  C CB  . GLU A 1 38  ? 12.867  0.030   45.405 1.00 19.73  ? 61  GLU A CB  1 ? 
ATOM   276  C CG  . GLU A 1 38  ? 13.285  -0.723  46.662 1.00 22.85  ? 61  GLU A CG  1 ? 
ATOM   277  C CD  . GLU A 1 38  ? 12.832  -2.167  46.669 1.00 34.82  ? 61  GLU A CD  1 ? 
ATOM   278  O OE1 . GLU A 1 38  ? 12.479  -2.665  45.585 1.00 28.04  ? 61  GLU A OE1 1 ? 
ATOM   279  O OE2 . GLU A 1 38  ? 12.837  -2.785  47.754 1.00 33.09  ? 61  GLU A OE2 1 ? 
ATOM   280  N N   . VAL A 1 39  ? 13.711  1.864   42.871 1.00 14.99  ? 62  VAL A N   1 ? 
ATOM   281  C CA  . VAL A 1 39  ? 13.338  2.612   41.640 1.00 15.13  ? 62  VAL A CA  1 ? 
ATOM   282  C C   . VAL A 1 39  ? 13.087  1.621   40.499 1.00 18.01  ? 62  VAL A C   1 ? 
ATOM   283  O O   . VAL A 1 39  ? 13.884  0.695   40.340 1.00 16.81  ? 62  VAL A O   1 ? 
ATOM   284  C CB  . VAL A 1 39  ? 14.352  3.695   41.221 1.00 18.09  ? 62  VAL A CB  1 ? 
ATOM   285  C CG1 . VAL A 1 39  ? 13.964  4.366   39.908 1.00 17.76  ? 62  VAL A CG1 1 ? 
ATOM   286  C CG2 . VAL A 1 39  ? 14.581  4.737   42.302 1.00 17.32  ? 62  VAL A CG2 1 ? 
ATOM   287  N N   . ASP A 1 40  ? 11.964  1.793   39.811 1.00 17.02  ? 63  ASP A N   1 ? 
ATOM   288  C CA  . ASP A 1 40  ? 11.694  0.949   38.617 1.00 17.73  ? 63  ASP A CA  1 ? 
ATOM   289  C C   . ASP A 1 40  ? 11.687  1.880   37.409 1.00 17.42  ? 63  ASP A C   1 ? 
ATOM   290  O O   . ASP A 1 40  ? 11.121  2.965   37.523 1.00 16.30  ? 63  ASP A O   1 ? 
ATOM   291  C CB  . ASP A 1 40  ? 10.428  0.122   38.727 1.00 18.69  ? 63  ASP A CB  1 ? 
ATOM   292  C CG  . ASP A 1 40  ? 10.254  -0.669  40.014 1.00 23.55  ? 63  ASP A CG  1 ? 
ATOM   293  O OD1 . ASP A 1 40  ? 11.224  -1.314  40.439 1.00 23.06  ? 63  ASP A OD1 1 ? 
ATOM   294  O OD2 . ASP A 1 40  ? 9.144   -0.635  40.570 1.00 28.65  ? 63  ASP A OD2 1 ? 
ATOM   295  N N   . VAL A 1 41  ? 12.302  1.434   36.327 1.00 15.37  ? 64  VAL A N   1 ? 
ATOM   296  C CA  . VAL A 1 41  ? 12.441  2.295   35.122 1.00 15.79  ? 64  VAL A CA  1 ? 
ATOM   297  C C   . VAL A 1 41  ? 11.703  1.630   33.952 1.00 16.50  ? 64  VAL A C   1 ? 
ATOM   298  O O   . VAL A 1 41  ? 11.923  0.447   33.736 1.00 16.29  ? 64  VAL A O   1 ? 
ATOM   299  C CB  . VAL A 1 41  ? 13.918  2.595   34.793 1.00 13.20  ? 64  VAL A CB  1 ? 
ATOM   300  C CG1 . VAL A 1 41  ? 14.072  3.344   33.477 1.00 13.23  ? 64  VAL A CG1 1 ? 
ATOM   301  C CG2 . VAL A 1 41  ? 14.592  3.364   35.921 1.00 13.01  ? 64  VAL A CG2 1 ? 
ATOM   302  N N   . TYR A 1 42  ? 10.856  2.395   33.269 1.00 16.25  ? 65  TYR A N   1 ? 
ATOM   303  C CA  . TYR A 1 42  ? 10.060  1.869   32.129 1.00 16.79  ? 65  TYR A CA  1 ? 
ATOM   304  C C   . TYR A 1 42  ? 10.345  2.732   30.897 1.00 15.24  ? 65  TYR A C   1 ? 
ATOM   305  O O   . TYR A 1 42  ? 9.787   3.818   30.715 1.00 16.70  ? 65  TYR A O   1 ? 
ATOM   306  C CB  . TYR A 1 42  ? 8.575   1.783   32.493 1.00 16.99  ? 65  TYR A CB  1 ? 
ATOM   307  C CG  . TYR A 1 42  ? 8.274   1.060   33.794 1.00 15.98  ? 65  TYR A CG  1 ? 
ATOM   308  C CD1 . TYR A 1 42  ? 8.268   1.738   35.004 1.00 16.42  ? 65  TYR A CD1 1 ? 
ATOM   309  C CD2 . TYR A 1 42  ? 7.992   -0.297  33.809 1.00 18.90  ? 65  TYR A CD2 1 ? 
ATOM   310  C CE1 . TYR A 1 42  ? 7.994   1.085   36.190 1.00 19.76  ? 65  TYR A CE1 1 ? 
ATOM   311  C CE2 . TYR A 1 42  ? 7.717   -0.963  34.990 1.00 19.79  ? 65  TYR A CE2 1 ? 
ATOM   312  C CZ  . TYR A 1 42  ? 7.717   -0.268  36.184 1.00 21.96  ? 65  TYR A CZ  1 ? 
ATOM   313  O OH  . TYR A 1 42  ? 7.445   -0.909  37.354 1.00 24.47  ? 65  TYR A OH  1 ? 
ATOM   314  N N   . PRO A 1 43  ? 11.252  2.258   30.030 1.00 15.91  ? 66  PRO A N   1 ? 
ATOM   315  C CA  . PRO A 1 43  ? 11.602  3.012   28.841 1.00 16.46  ? 66  PRO A CA  1 ? 
ATOM   316  C C   . PRO A 1 43  ? 10.760  2.817   27.586 1.00 19.34  ? 66  PRO A C   1 ? 
ATOM   317  O O   . PRO A 1 43  ? 9.922   1.926   27.534 1.00 17.60  ? 66  PRO A O   1 ? 
ATOM   318  C CB  . PRO A 1 43  ? 13.004  2.426   28.616 1.00 14.45  ? 66  PRO A CB  1 ? 
ATOM   319  C CG  . PRO A 1 43  ? 12.827  0.964   28.925 1.00 13.74  ? 66  PRO A CG  1 ? 
ATOM   320  C CD  . PRO A 1 43  ? 11.983  1.011   30.181 1.00 15.51  ? 66  PRO A CD  1 ? 
ATOM   321  N N   . ASN A 1 44  ? 10.971  3.676   26.598 1.00 17.07  ? 67  ASN A N   1 ? 
ATOM   322  C CA  . ASN A 1 44  ? 10.373  3.435   25.260 1.00 17.93  ? 67  ASN A CA  1 ? 
ATOM   323  C C   . ASN A 1 44  ? 8.856   3.227   25.311 1.00 18.05  ? 67  ASN A C   1 ? 
ATOM   324  O O   . ASN A 1 44  ? 8.369   2.388   24.564 1.00 18.85  ? 67  ASN A O   1 ? 
ATOM   325  C CB  . ASN A 1 44  ? 11.124  2.293   24.593 1.00 21.21  ? 67  ASN A CB  1 ? 
ATOM   326  C CG  . ASN A 1 44  ? 11.327  2.512   23.116 1.00 26.53  ? 67  ASN A CG  1 ? 
ATOM   327  O OD1 . ASN A 1 44  ? 11.357  3.655   22.655 1.00 30.62  ? 67  ASN A OD1 1 ? 
ATOM   328  N ND2 . ASN A 1 44  ? 11.452  1.429   22.364 1.00 31.48  ? 67  ASN A ND2 1 ? 
ATOM   329  N N   . SER A 1 45  ? 8.163   3.991   26.145 1.00 15.53  ? 68  SER A N   1 ? 
ATOM   330  C CA  . SER A 1 45  ? 6.682   3.925   26.218 1.00 18.05  ? 68  SER A CA  1 ? 
ATOM   331  C C   . SER A 1 45  ? 6.221   2.513   26.621 1.00 18.11  ? 68  SER A C   1 ? 
ATOM   332  O O   . SER A 1 45  ? 5.091   2.169   26.316 1.00 20.15  ? 68  SER A O   1 ? 
ATOM   333  C CB  . SER A 1 45  ? 6.070   4.398   24.916 1.00 17.20  ? 68  SER A CB  1 ? 
ATOM   334  O OG  . SER A 1 45  ? 6.498   5.705   24.569 1.00 22.46  ? 68  SER A OG  1 ? 
ATOM   335  N N   . SER A 1 46  ? 7.078   1.767   27.310 1.00 16.13  ? 69  SER A N   1 ? 
ATOM   336  C CA  . SER A 1 46  ? 6.766   0.387   27.746 1.00 19.70  ? 69  SER A CA  1 ? 
ATOM   337  C C   . SER A 1 46  ? 5.657   0.378   28.806 1.00 22.21  ? 69  SER A C   1 ? 
ATOM   338  O O   . SER A 1 46  ? 4.958   -0.623  28.900 1.00 20.24  ? 69  SER A O   1 ? 
ATOM   339  C CB  . SER A 1 46  ? 8.013   -0.289  28.295 1.00 17.54  ? 69  SER A CB  1 ? 
ATOM   340  O OG  . SER A 1 46  ? 8.616   0.456   29.336 1.00 19.25  ? 69  SER A OG  1 ? 
ATOM   341  N N   . LEU A 1 47  ? 5.568   1.438   29.603 1.00 15.57  ? 70  LEU A N   1 ? 
ATOM   342  C CA  . LEU A 1 47  ? 4.491   1.536   30.617 1.00 16.71  ? 70  LEU A CA  1 ? 
ATOM   343  C C   . LEU A 1 47  ? 3.517   2.637   30.183 1.00 18.03  ? 70  LEU A C   1 ? 
ATOM   344  O O   . LEU A 1 47  ? 2.334   2.362   30.072 1.00 17.85  ? 70  LEU A O   1 ? 
ATOM   345  C CB  . LEU A 1 47  ? 5.030   1.816   32.011 1.00 17.14  ? 70  LEU A CB  1 ? 
ATOM   346  C CG  . LEU A 1 47  ? 4.015   1.723   33.149 1.00 18.61  ? 70  LEU A CG  1 ? 
ATOM   347  C CD1 . LEU A 1 47  ? 3.633   0.270   33.344 1.00 19.95  ? 70  LEU A CD1 1 ? 
ATOM   348  C CD2 . LEU A 1 47  ? 4.611   2.307   34.412 1.00 16.21  ? 70  LEU A CD2 1 ? 
ATOM   349  N N   . PHE A 1 48  ? 4.055   3.828   29.933 1.00 18.45  ? 71  PHE A N   1 ? 
ATOM   350  C CA  . PHE A 1 48  ? 3.198   4.959   29.516 1.00 18.40  ? 71  PHE A CA  1 ? 
ATOM   351  C C   . PHE A 1 48  ? 3.871   5.757   28.429 1.00 17.01  ? 71  PHE A C   1 ? 
ATOM   352  O O   . PHE A 1 48  ? 5.074   6.001   28.483 1.00 17.07  ? 71  PHE A O   1 ? 
ATOM   353  C CB  . PHE A 1 48  ? 2.839   5.868   30.690 1.00 17.85  ? 71  PHE A CB  1 ? 
ATOM   354  C CG  . PHE A 1 48  ? 2.032   5.205   31.794 1.00 20.26  ? 71  PHE A CG  1 ? 
ATOM   355  C CD1 . PHE A 1 48  ? 0.758   4.713   31.549 1.00 20.60  ? 71  PHE A CD1 1 ? 
ATOM   356  C CD2 . PHE A 1 48  ? 2.550   5.078   33.075 1.00 22.37  ? 71  PHE A CD2 1 ? 
ATOM   357  C CE1 . PHE A 1 48  ? 0.030   4.106   32.556 1.00 19.97  ? 71  PHE A CE1 1 ? 
ATOM   358  C CE2 . PHE A 1 48  ? 1.817   4.466   34.075 1.00 23.75  ? 71  PHE A CE2 1 ? 
ATOM   359  C CZ  . PHE A 1 48  ? 0.561   3.983   33.814 1.00 20.32  ? 71  PHE A CZ  1 ? 
ATOM   360  N N   . GLY A 1 49  ? 3.061   6.147   27.454 1.00 16.55  ? 72  GLY A N   1 ? 
ATOM   361  C CA  . GLY A 1 49  ? 3.568   7.011   26.394 1.00 16.04  ? 72  GLY A CA  1 ? 
ATOM   362  C C   . GLY A 1 49  ? 3.190   8.453   26.634 1.00 15.52  ? 72  GLY A C   1 ? 
ATOM   363  O O   . GLY A 1 49  ? 2.721   8.778   27.717 1.00 16.79  ? 72  GLY A O   1 ? 
ATOM   364  N N   . ASP A 1 50  ? 3.374   9.275   25.611 1.00 14.57  ? 73  ASP A N   1 ? 
ATOM   365  C CA  . ASP A 1 50  ? 3.065   10.717  25.720 1.00 17.54  ? 73  ASP A CA  1 ? 
ATOM   366  C C   . ASP A 1 50  ? 1.629   10.954  26.205 1.00 18.00  ? 73  ASP A C   1 ? 
ATOM   367  O O   . ASP A 1 50  ? 0.739   10.200  25.797 1.00 18.01  ? 73  ASP A O   1 ? 
ATOM   368  C CB  . ASP A 1 50  ? 3.286   11.402  24.380 1.00 18.04  ? 73  ASP A CB  1 ? 
ATOM   369  C CG  . ASP A 1 50  ? 4.725   11.677  23.976 1.00 20.57  ? 73  ASP A CG  1 ? 
ATOM   370  O OD1 . ASP A 1 50  ? 5.610   11.576  24.844 1.00 21.07  ? 73  ASP A OD1 1 ? 
ATOM   371  O OD2 . ASP A 1 50  ? 4.939   12.016  22.796 1.00 16.34  ? 73  ASP A OD2 1 ? 
ATOM   372  N N   . GLY A 1 51  ? 1.429   12.008  26.988 1.00 16.14  ? 74  GLY A N   1 ? 
ATOM   373  C CA  . GLY A 1 51  ? 0.098   12.397  27.483 1.00 17.10  ? 74  GLY A CA  1 ? 
ATOM   374  C C   . GLY A 1 51  ? -0.355  11.502  28.607 1.00 14.46  ? 74  GLY A C   1 ? 
ATOM   375  O O   . GLY A 1 51  ? -0.491  11.988  29.733 1.00 19.03  ? 74  GLY A O   1 ? 
ATOM   376  N N   . LYS A 1 52  ? -0.566  10.231  28.293 1.00 18.95  ? 75  LYS A N   1 ? 
ATOM   377  C CA  . LYS A 1 52  ? -0.970  9.236   29.312 1.00 19.27  ? 75  LYS A CA  1 ? 
ATOM   378  C C   . LYS A 1 52  ? -0.025  9.309   30.520 1.00 19.84  ? 75  LYS A C   1 ? 
ATOM   379  O O   . LYS A 1 52  ? -0.495  9.223   31.653 1.00 21.37  ? 75  LYS A O   1 ? 
ATOM   380  C CB  . LYS A 1 52  ? -0.918  7.866   28.636 1.00 23.53  ? 75  LYS A CB  1 ? 
ATOM   381  C CG  . LYS A 1 52  ? -1.451  6.722   29.473 1.00 28.48  ? 75  LYS A CG  1 ? 
ATOM   382  C CD  . LYS A 1 52  ? -2.913  6.924   29.840 1.00 29.86  ? 75  LYS A CD  1 ? 
ATOM   383  C CE  . LYS A 1 52  ? -3.550  5.677   30.345 1.00 36.95  ? 75  LYS A CE  1 ? 
ATOM   384  N NZ  . LYS A 1 52  ? -3.456  4.612   29.343 1.00 49.18  ? 75  LYS A NZ  1 ? 
ATOM   385  N N   . GLU A 1 53  ? 1.268   9.483   30.266 1.00 18.40  ? 76  GLU A N   1 ? 
ATOM   386  C CA  . GLU A 1 53  ? 2.251   9.492   31.379 1.00 18.95  ? 76  GLU A CA  1 ? 
ATOM   387  C C   . GLU A 1 53  ? 1.858   10.549  32.446 1.00 18.09  ? 76  GLU A C   1 ? 
ATOM   388  O O   . GLU A 1 53  ? 1.900   10.231  33.633 1.00 14.59  ? 76  GLU A O   1 ? 
ATOM   389  C CB  . GLU A 1 53  ? 3.634   9.640   30.744 1.00 18.29  ? 76  GLU A CB  1 ? 
ATOM   390  C CG  . GLU A 1 53  ? 3.842   10.953  29.996 1.00 18.01  ? 76  GLU A CG  1 ? 
ATOM   391  C CD  . GLU A 1 53  ? 5.296   11.318  29.754 1.00 19.07  ? 76  GLU A CD  1 ? 
ATOM   392  O OE1 . GLU A 1 53  ? 5.540   12.384  29.176 1.00 19.97  ? 76  GLU A OE1 1 ? 
ATOM   393  O OE2 . GLU A 1 53  ? 6.181   10.539  30.140 1.00 19.71  ? 76  GLU A OE2 1 ? 
ATOM   394  N N   . MET A 1 54  ? 1.469   11.751  32.017 1.00 17.54  ? 77  MET A N   1 ? 
ATOM   395  C CA  . MET A 1 54  ? 1.116   12.842  32.963 1.00 19.45  ? 77  MET A CA  1 ? 
ATOM   396  C C   . MET A 1 54  ? -0.196  12.519  33.697 1.00 18.24  ? 77  MET A C   1 ? 
ATOM   397  O O   . MET A 1 54  ? -0.310  12.826  34.883 1.00 19.23  ? 77  MET A O   1 ? 
ATOM   398  C CB  . MET A 1 54  ? 0.929   14.155  32.205 1.00 21.77  ? 77  MET A CB  1 ? 
ATOM   399  C CG  . MET A 1 54  ? 2.145   14.596  31.447 1.00 32.35  ? 77  MET A CG  1 ? 
ATOM   400  S SD  . MET A 1 54  ? 3.338   15.069  32.706 1.00 32.37  ? 77  MET A SD  1 ? 
ATOM   401  C CE  . MET A 1 54  ? 2.782   16.713  33.172 1.00 21.93  ? 77  MET A CE  1 ? 
ATOM   402  N N   . GLU A 1 55  ? -1.151  11.949  32.980 1.00 18.87  ? 78  GLU A N   1 ? 
ATOM   403  C CA  . GLU A 1 55  ? -2.417  11.530  33.617 1.00 17.93  ? 78  GLU A CA  1 ? 
ATOM   404  C C   . GLU A 1 55  ? -2.061  10.535  34.734 1.00 15.78  ? 78  GLU A C   1 ? 
ATOM   405  O O   . GLU A 1 55  ? -2.522  10.706  35.843 1.00 18.18  ? 78  GLU A O   1 ? 
ATOM   406  C CB  . GLU A 1 55  ? -3.339  10.964  32.537 1.00 19.49  ? 78  GLU A CB  1 ? 
ATOM   407  C CG  . GLU A 1 55  ? -3.731  11.972  31.464 1.00 20.85  ? 78  GLU A CG  1 ? 
ATOM   408  C CD  . GLU A 1 55  ? -4.089  11.362  30.121 1.00 23.98  ? 78  GLU A CD  1 ? 
ATOM   409  O OE1 . GLU A 1 55  ? -4.103  12.121  29.140 1.00 35.04  ? 78  GLU A OE1 1 ? 
ATOM   410  O OE2 . GLU A 1 55  ? -4.349  10.152  30.043 1.00 22.69  ? 78  GLU A OE2 1 ? 
ATOM   411  N N   . ALA A 1 56  ? -1.195  9.579   34.421 1.00 15.51  ? 79  ALA A N   1 ? 
ATOM   412  C CA  . ALA A 1 56  ? -0.756  8.566   35.408 1.00 16.00  ? 79  ALA A CA  1 ? 
ATOM   413  C C   . ALA A 1 56  ? 0.012   9.207   36.571 1.00 14.93  ? 79  ALA A C   1 ? 
ATOM   414  O O   . ALA A 1 56  ? -0.162  8.794   37.714 1.00 16.69  ? 79  ALA A O   1 ? 
ATOM   415  C CB  . ALA A 1 56  ? 0.085   7.550   34.700 1.00 15.61  ? 79  ALA A CB  1 ? 
ATOM   416  N N   . LEU A 1 57  ? 0.860   10.184  36.259 1.00 16.51  ? 80  LEU A N   1 ? 
ATOM   417  C CA  . LEU A 1 57  ? 1.614   10.892  37.319 1.00 18.76  ? 80  LEU A CA  1 ? 
ATOM   418  C C   . LEU A 1 57  ? 0.609   11.505  38.301 1.00 15.79  ? 80  LEU A C   1 ? 
ATOM   419  O O   . LEU A 1 57  ? 0.786   11.343  39.512 1.00 15.76  ? 80  LEU A O   1 ? 
ATOM   420  C CB  . LEU A 1 57  ? 2.516   11.991  36.761 1.00 15.97  ? 80  LEU A CB  1 ? 
ATOM   421  C CG  . LEU A 1 57  ? 3.465   12.645  37.765 1.00 16.87  ? 80  LEU A CG  1 ? 
ATOM   422  C CD1 . LEU A 1 57  ? 4.409   11.609  38.330 1.00 15.70  ? 80  LEU A CD1 1 ? 
ATOM   423  C CD2 . LEU A 1 57  ? 4.233   13.772  37.114 1.00 17.92  ? 80  LEU A CD2 1 ? 
ATOM   424  N N   . LEU A 1 58  ? -0.384  12.204  37.764 1.00 16.08  ? 81  LEU A N   1 ? 
ATOM   425  C CA  . LEU A 1 58  ? -1.370  12.894  38.634 1.00 17.09  ? 81  LEU A CA  1 ? 
ATOM   426  C C   . LEU A 1 58  ? -2.205  11.850  39.401 1.00 16.29  ? 81  LEU A C   1 ? 
ATOM   427  O O   . LEU A 1 58  ? -2.627  12.138  40.503 1.00 17.67  ? 81  LEU A O   1 ? 
ATOM   428  C CB  . LEU A 1 58  ? -2.207  13.828  37.772 1.00 17.44  ? 81  LEU A CB  1 ? 
ATOM   429  C CG  . LEU A 1 58  ? -1.471  15.078  37.289 1.00 19.45  ? 81  LEU A CG  1 ? 
ATOM   430  C CD1 . LEU A 1 58  ? -2.204  15.748  36.153 1.00 23.90  ? 81  LEU A CD1 1 ? 
ATOM   431  C CD2 . LEU A 1 58  ? -1.313  16.021  38.457 1.00 20.61  ? 81  LEU A CD2 1 ? 
ATOM   432  N N   . LEU A 1 59  ? -2.376  10.667  38.813 1.00 17.72  ? 82  LEU A N   1 ? 
ATOM   433  C CA  . LEU A 1 59  ? -3.173  9.606   39.478 1.00 17.58  ? 82  LEU A CA  1 ? 
ATOM   434  C C   . LEU A 1 59  ? -2.328  8.835   40.516 1.00 23.36  ? 82  LEU A C   1 ? 
ATOM   435  O O   . LEU A 1 59  ? -2.923  8.219   41.397 1.00 18.61  ? 82  LEU A O   1 ? 
ATOM   436  C CB  . LEU A 1 59  ? -3.728  8.633   38.443 1.00 20.21  ? 82  LEU A CB  1 ? 
ATOM   437  C CG  . LEU A 1 59  ? -5.208  8.735   38.078 1.00 27.85  ? 82  LEU A CG  1 ? 
ATOM   438  C CD1 . LEU A 1 59  ? -5.574  7.432   37.393 1.00 21.65  ? 82  LEU A CD1 1 ? 
ATOM   439  C CD2 . LEU A 1 59  ? -6.074  8.962   39.299 1.00 22.10  ? 82  LEU A CD2 1 ? 
ATOM   440  N N   . GLY A 1 60  ? -1.000  8.838   40.373 1.00 24.38  ? 83  GLY A N   1 ? 
ATOM   441  C CA  . GLY A 1 60  ? -0.131  8.075   41.287 1.00 22.66  ? 83  GLY A CA  1 ? 
ATOM   442  C C   . GLY A 1 60  ? 0.210   6.699   40.746 1.00 21.84  ? 83  GLY A C   1 ? 
ATOM   443  O O   . GLY A 1 60  ? 0.695   5.871   41.514 1.00 20.44  ? 83  GLY A O   1 ? 
ATOM   444  N N   . ASP A 1 61  ? -0.003  6.485   39.452 1.00 18.83  ? 84  ASP A N   1 ? 
ATOM   445  C CA  . ASP A 1 61  ? 0.409   5.198   38.833 1.00 18.98  ? 84  ASP A CA  1 ? 
ATOM   446  C C   . ASP A 1 61  ? 1.905   5.264   38.514 1.00 20.31  ? 84  ASP A C   1 ? 
ATOM   447  O O   . ASP A 1 61  ? 2.494   4.215   38.233 1.00 21.28  ? 84  ASP A O   1 ? 
ATOM   448  C CB  . ASP A 1 61  ? -0.467  4.861   37.645 1.00 21.45  ? 84  ASP A CB  1 ? 
ATOM   449  C CG  . ASP A 1 61  ? -1.923  4.605   37.992 1.00 31.82  ? 84  ASP A CG  1 ? 
ATOM   450  O OD1 . ASP A 1 61  ? -2.160  3.835   38.934 1.00 35.08  ? 84  ASP A OD1 1 ? 
ATOM   451  O OD2 . ASP A 1 61  ? -2.795  5.184   37.323 1.00 36.39  ? 84  ASP A OD2 1 ? 
ATOM   452  N N   . VAL A 1 62  ? 2.473   6.464   38.532 1.00 16.06  ? 85  VAL A N   1 ? 
ATOM   453  C CA  . VAL A 1 62  ? 3.938   6.642   38.321 1.00 16.15  ? 85  VAL A CA  1 ? 
ATOM   454  C C   . VAL A 1 62  ? 4.380   7.771   39.272 1.00 16.95  ? 85  VAL A C   1 ? 
ATOM   455  O O   . VAL A 1 62  ? 3.523   8.542   39.668 1.00 19.96  ? 85  VAL A O   1 ? 
ATOM   456  C CB  . VAL A 1 62  ? 4.255   6.941   36.834 1.00 18.28  ? 85  VAL A CB  1 ? 
ATOM   457  C CG1 . VAL A 1 62  ? 3.821   8.323   36.382 1.00 15.84  ? 85  VAL A CG1 1 ? 
ATOM   458  C CG2 . VAL A 1 62  ? 5.686   6.632   36.431 1.00 23.39  ? 85  VAL A CG2 1 ? 
ATOM   459  N N   . GLN A 1 63  ? 5.664   7.838   39.604 1.00 16.32  ? 86  GLN A N   1 ? 
ATOM   460  C CA  . GLN A 1 63  ? 6.154   8.828   40.592 1.00 16.21  ? 86  GLN A CA  1 ? 
ATOM   461  C C   . GLN A 1 63  ? 7.156   9.801   39.945 1.00 16.22  ? 86  GLN A C   1 ? 
ATOM   462  O O   . GLN A 1 63  ? 7.460   10.829  40.540 1.00 19.39  ? 86  GLN A O   1 ? 
ATOM   463  C CB  . GLN A 1 63  ? 6.767   8.093   41.782 1.00 17.12  ? 86  GLN A CB  1 ? 
ATOM   464  C CG  . GLN A 1 63  ? 5.750   7.433   42.704 1.00 14.65  ? 86  GLN A CG  1 ? 
ATOM   465  C CD  . GLN A 1 63  ? 5.153   6.174   42.121 1.00 17.47  ? 86  GLN A CD  1 ? 
ATOM   466  O OE1 . GLN A 1 63  ? 5.850   5.373   41.496 1.00 21.15  ? 86  GLN A OE1 1 ? 
ATOM   467  N NE2 . GLN A 1 63  ? 3.852   6.004   42.297 1.00 15.01  ? 86  GLN A NE2 1 ? 
ATOM   468  N N   . MET A 1 64  ? 7.665   9.449   38.780 1.00 15.78  ? 87  MET A N   1 ? 
ATOM   469  C CA  . MET A 1 64  ? 8.673   10.336  38.162 1.00 16.80  ? 87  MET A CA  1 ? 
ATOM   470  C C   . MET A 1 64  ? 8.625   10.267  36.640 1.00 17.01  ? 87  MET A C   1 ? 
ATOM   471  O O   . MET A 1 64  ? 8.471   9.183   36.113 1.00 16.36  ? 87  MET A O   1 ? 
ATOM   472  C CB  . MET A 1 64  ? 10.086  10.005  38.638 1.00 16.82  ? 87  MET A CB  1 ? 
ATOM   473  C CG  . MET A 1 64  ? 11.143  11.042  38.320 1.00 17.22  ? 87  MET A CG  1 ? 
ATOM   474  S SD  . MET A 1 64  ? 12.700  10.621  39.127 1.00 17.54  ? 87  MET A SD  1 ? 
ATOM   475  C CE  . MET A 1 64  ? 12.363  11.226  40.786 1.00 16.20  ? 87  MET A CE  1 ? 
ATOM   476  N N   . LEU A 1 65  ? 8.761   11.429  36.015 1.00 13.39  ? 88  LEU A N   1 ? 
ATOM   477  C CA  . LEU A 1 65  ? 8.796   11.527  34.547 1.00 14.44  ? 88  LEU A CA  1 ? 
ATOM   478  C C   . LEU A 1 65  ? 9.848   12.574  34.159 1.00 15.71  ? 88  LEU A C   1 ? 
ATOM   479  O O   . LEU A 1 65  ? 10.312  13.310  35.029 1.00 13.92  ? 88  LEU A O   1 ? 
ATOM   480  C CB  . LEU A 1 65  ? 7.442   11.982  34.009 1.00 13.14  ? 88  LEU A CB  1 ? 
ATOM   481  C CG  . LEU A 1 65  ? 6.218   11.120  34.330 1.00 12.61  ? 88  LEU A CG  1 ? 
ATOM   482  C CD1 . LEU A 1 65  ? 4.978   11.849  33.865 1.00 15.00  ? 88  LEU A CD1 1 ? 
ATOM   483  C CD2 . LEU A 1 65  ? 6.303   9.760   33.678 1.00 12.95  ? 88  LEU A CD2 1 ? 
ATOM   484  N N   . ALA A 1 66  ? 10.169  12.631  32.879 1.00 14.81  ? 89  ALA A N   1 ? 
ATOM   485  C CA  . ALA A 1 66  ? 11.032  13.725  32.388 1.00 15.21  ? 89  ALA A CA  1 ? 
ATOM   486  C C   . ALA A 1 66  ? 10.587  14.040  30.948 1.00 14.98  ? 89  ALA A C   1 ? 
ATOM   487  O O   . ALA A 1 66  ? 11.292  13.750  30.007 1.00 14.02  ? 89  ALA A O   1 ? 
ATOM   488  C CB  . ALA A 1 66  ? 12.482  13.358  32.491 1.00 14.71  ? 89  ALA A CB  1 ? 
ATOM   489  N N   . PRO A 1 67  ? 9.396   14.645  30.782 1.00 16.04  ? 90  PRO A N   1 ? 
ATOM   490  C CA  . PRO A 1 67  ? 8.873   14.923  29.460 1.00 13.06  ? 90  PRO A CA  1 ? 
ATOM   491  C C   . PRO A 1 67  ? 9.519   16.122  28.794 1.00 13.71  ? 90  PRO A C   1 ? 
ATOM   492  O O   . PRO A 1 67  ? 10.014  16.988  29.504 1.00 16.70  ? 90  PRO A O   1 ? 
ATOM   493  C CB  . PRO A 1 67  ? 7.392   15.193  29.775 1.00 13.91  ? 90  PRO A CB  1 ? 
ATOM   494  C CG  . PRO A 1 67  ? 7.190   14.778  31.205 1.00 14.04  ? 90  PRO A CG  1 ? 
ATOM   495  C CD  . PRO A 1 67  ? 8.520   15.085  31.841 1.00 16.61  ? 90  PRO A CD  1 ? 
ATOM   496  N N   . SER A 1 68  ? 9.477   16.169  27.468 1.00 13.11  ? 91  SER A N   1 ? 
ATOM   497  C CA  . SER A 1 68  ? 9.971   17.362  26.746 1.00 13.82  ? 91  SER A CA  1 ? 
ATOM   498  C C   . SER A 1 68  ? 9.226   18.605  27.237 1.00 14.74  ? 91  SER A C   1 ? 
ATOM   499  O O   . SER A 1 68  ? 8.034   18.519  27.479 1.00 13.19  ? 91  SER A O   1 ? 
ATOM   500  C CB  . SER A 1 68  ? 9.871   17.258  25.227 1.00 13.17  ? 91  SER A CB  1 ? 
ATOM   501  O OG  . SER A 1 68  ? 9.976   18.512  24.579 1.00 13.33  ? 91  SER A OG  1 ? 
ATOM   502  N N   . LEU A 1 69  ? 9.934   19.728  27.273 1.00 13.73  ? 92  LEU A N   1 ? 
ATOM   503  C CA  . LEU A 1 69  ? 9.323   21.016  27.678 1.00 13.86  ? 92  LEU A CA  1 ? 
ATOM   504  C C   . LEU A 1 69  ? 8.225   21.430  26.681 1.00 16.43  ? 92  LEU A C   1 ? 
ATOM   505  O O   . LEU A 1 69  ? 7.494   22.368  26.968 1.00 16.26  ? 92  LEU A O   1 ? 
ATOM   506  C CB  . LEU A 1 69  ? 10.461  22.028  27.730 1.00 14.54  ? 92  LEU A CB  1 ? 
ATOM   507  C CG  . LEU A 1 69  ? 11.549  21.740  28.768 1.00 13.98  ? 92  LEU A CG  1 ? 
ATOM   508  C CD1 . LEU A 1 69  ? 12.782  22.596  28.573 1.00 12.74  ? 92  LEU A CD1 1 ? 
ATOM   509  C CD2 . LEU A 1 69  ? 10.987  21.903  30.160 1.00 16.12  ? 92  LEU A CD2 1 ? 
ATOM   510  N N   . ALA A 1 70  ? 8.144   20.755  25.537 1.00 15.17  ? 93  ALA A N   1 ? 
ATOM   511  C CA  . ALA A 1 70  ? 7.069   21.027  24.559 1.00 16.04  ? 93  ALA A CA  1 ? 
ATOM   512  C C   . ALA A 1 70  ? 5.740   20.379  24.962 1.00 15.59  ? 93  ALA A C   1 ? 
ATOM   513  O O   . ALA A 1 70  ? 4.760   20.631  24.266 1.00 17.68  ? 93  ALA A O   1 ? 
ATOM   514  C CB  . ALA A 1 70  ? 7.501   20.464  23.240 1.00 20.66  ? 93  ALA A CB  1 ? 
ATOM   515  N N   . LYS A 1 71  ? 5.716   19.576  26.024 1.00 12.24  ? 94  LYS A N   1 ? 
ATOM   516  C CA  . LYS A 1 71  ? 4.514   18.776  26.354 1.00 13.91  ? 94  LYS A CA  1 ? 
ATOM   517  C C   . LYS A 1 71  ? 3.772   19.227  27.636 1.00 14.79  ? 94  LYS A C   1 ? 
ATOM   518  O O   . LYS A 1 71  ? 3.062   18.404  28.187 1.00 17.09  ? 94  LYS A O   1 ? 
ATOM   519  C CB  . LYS A 1 71  ? 5.024   17.328  26.387 1.00 13.73  ? 94  LYS A CB  1 ? 
ATOM   520  C CG  . LYS A 1 71  ? 5.535   16.822  25.048 1.00 14.21  ? 94  LYS A CG  1 ? 
ATOM   521  C CD  . LYS A 1 71  ? 6.065   15.396  25.060 1.00 16.89  ? 94  LYS A CD  1 ? 
ATOM   522  C CE  . LYS A 1 71  ? 6.515   14.958  23.708 1.00 13.54  ? 94  LYS A CE  1 ? 
ATOM   523  N NZ  . LYS A 1 71  ? 7.335   13.750  23.762 1.00 15.63  ? 94  LYS A NZ  1 ? 
ATOM   524  N N   . PHE A 1 72  ? 3.836   20.506  27.984 1.00 14.25  ? 95  PHE A N   1 ? 
ATOM   525  C CA  . PHE A 1 72  ? 3.236   21.000  29.254 1.00 14.79  ? 95  PHE A CA  1 ? 
ATOM   526  C C   . PHE A 1 72  ? 2.136   22.069  29.051 1.00 16.64  ? 95  PHE A C   1 ? 
ATOM   527  O O   . PHE A 1 72  ? 1.718   22.681  30.036 1.00 13.65  ? 95  PHE A O   1 ? 
ATOM   528  C CB  . PHE A 1 72  ? 4.404   21.557  30.059 1.00 13.98  ? 95  PHE A CB  1 ? 
ATOM   529  C CG  . PHE A 1 72  ? 5.374   20.506  30.578 1.00 18.20  ? 95  PHE A CG  1 ? 
ATOM   530  C CD1 . PHE A 1 72  ? 4.960   19.536  31.481 1.00 18.10  ? 95  PHE A CD1 1 ? 
ATOM   531  C CD2 . PHE A 1 72  ? 6.697   20.485  30.157 1.00 17.38  ? 95  PHE A CD2 1 ? 
ATOM   532  C CE1 . PHE A 1 72  ? 5.845   18.582  31.951 1.00 17.98  ? 95  PHE A CE1 1 ? 
ATOM   533  C CE2 . PHE A 1 72  ? 7.577   19.529  30.633 1.00 18.42  ? 95  PHE A CE2 1 ? 
ATOM   534  C CZ  . PHE A 1 72  ? 7.149   18.583  31.529 1.00 14.43  ? 95  PHE A CZ  1 ? 
ATOM   535  N N   . GLU A 1 73  ? 1.674   22.253  27.822 1.00 14.67  ? 96  GLU A N   1 ? 
ATOM   536  C CA  . GLU A 1 73  ? 0.707   23.360  27.554 1.00 20.45  ? 96  GLU A CA  1 ? 
ATOM   537  C C   . GLU A 1 73  ? -0.627  23.150  28.313 1.00 19.08  ? 96  GLU A C   1 ? 
ATOM   538  O O   . GLU A 1 73  ? -1.316  24.132  28.544 1.00 16.73  ? 96  GLU A O   1 ? 
ATOM   539  C CB  . GLU A 1 73  ? 0.466   23.597  26.061 1.00 16.49  ? 96  GLU A CB  1 ? 
ATOM   540  C CG  . GLU A 1 73  ? 1.642   24.263  25.355 1.00 23.18  ? 96  GLU A CG  1 ? 
ATOM   541  C CD  . GLU A 1 73  ? 1.561   24.231  23.838 1.00 26.75  ? 96  GLU A CD  1 ? 
ATOM   542  O OE1 . GLU A 1 73  ? 0.700   23.500  23.309 1.00 26.33  ? 96  GLU A OE1 1 ? 
ATOM   543  O OE2 . GLU A 1 73  ? 2.356   24.937  23.190 1.00 22.51  ? 96  GLU A OE2 1 ? 
ATOM   544  N N   . GLN A 1 74  ? -0.945  21.911  28.693 1.00 16.10  ? 97  GLN A N   1 ? 
ATOM   545  C CA  . GLN A 1 74  ? -2.229  21.671  29.385 1.00 18.94  ? 97  GLN A CA  1 ? 
ATOM   546  C C   . GLN A 1 74  ? -2.096  22.099  30.848 1.00 21.22  ? 97  GLN A C   1 ? 
ATOM   547  O O   . GLN A 1 74  ? -3.122  22.145  31.525 1.00 20.11  ? 97  GLN A O   1 ? 
ATOM   548  C CB  . GLN A 1 74  ? -2.612  20.199  29.295 1.00 18.35  ? 97  GLN A CB  1 ? 
ATOM   549  C CG  . GLN A 1 74  ? -2.930  19.711  27.891 1.00 20.85  ? 97  GLN A CG  1 ? 
ATOM   550  C CD  . GLN A 1 74  ? -2.789  18.212  27.770 1.00 23.47  ? 97  GLN A CD  1 ? 
ATOM   551  O OE1 . GLN A 1 74  ? -1.714  17.650  27.992 1.00 33.98  ? 97  GLN A OE1 1 ? 
ATOM   552  N NE2 . GLN A 1 74  ? -3.881  17.551  27.424 1.00 23.57  ? 97  GLN A NE2 1 ? 
ATOM   553  N N   . TYR A 1 75  ? -0.870  22.389  31.294 1.00 19.22  ? 98  TYR A N   1 ? 
ATOM   554  C CA  . TYR A 1 75  ? -0.621  22.673  32.735 1.00 16.88  ? 98  TYR A CA  1 ? 
ATOM   555  C C   . TYR A 1 75  ? -0.125  24.077  32.911 1.00 19.42  ? 98  TYR A C   1 ? 
ATOM   556  O O   . TYR A 1 75  ? -0.387  24.647  33.962 1.00 21.47  ? 98  TYR A O   1 ? 
ATOM   557  C CB  . TYR A 1 75  ? 0.401   21.670  33.261 1.00 15.16  ? 98  TYR A CB  1 ? 
ATOM   558  C CG  . TYR A 1 75  ? 0.017   20.246  32.907 1.00 15.23  ? 98  TYR A CG  1 ? 
ATOM   559  C CD1 . TYR A 1 75  ? -0.898  19.547  33.678 1.00 15.41  ? 98  TYR A CD1 1 ? 
ATOM   560  C CD2 . TYR A 1 75  ? 0.531   19.627  31.777 1.00 18.82  ? 98  TYR A CD2 1 ? 
ATOM   561  C CE1 . TYR A 1 75  ? -1.272  18.258  33.350 1.00 18.56  ? 98  TYR A CE1 1 ? 
ATOM   562  C CE2 . TYR A 1 75  ? 0.160   18.342  31.434 1.00 16.42  ? 98  TYR A CE2 1 ? 
ATOM   563  C CZ  . TYR A 1 75  ? -0.741  17.658  32.226 1.00 17.54  ? 98  TYR A CZ  1 ? 
ATOM   564  O OH  . TYR A 1 75  ? -1.112  16.398  31.897 1.00 19.91  ? 98  TYR A OH  1 ? 
ATOM   565  N N   . THR A 1 76  ? 0.602   24.587  31.929 1.00 16.83  ? 99  THR A N   1 ? 
ATOM   566  C CA  . THR A 1 76  ? 1.030   25.996  31.943 1.00 19.45  ? 99  THR A CA  1 ? 
ATOM   567  C C   . THR A 1 76  ? 1.340   26.395  30.529 1.00 19.02  ? 99  THR A C   1 ? 
ATOM   568  O O   . THR A 1 76  ? 1.641   25.510  29.733 1.00 20.04  ? 99  THR A O   1 ? 
ATOM   569  C CB  . THR A 1 76  ? 2.273   26.237  32.798 1.00 23.37  ? 99  THR A CB  1 ? 
ATOM   570  O OG1 . THR A 1 76  ? 2.685   27.587  32.620 1.00 20.51  ? 99  THR A OG1 1 ? 
ATOM   571  C CG2 . THR A 1 76  ? 3.418   25.318  32.418 1.00 22.52  ? 99  THR A CG2 1 ? 
ATOM   572  N N   . ARG A 1 77  ? 1.304   27.691  30.253 1.00 21.05  ? 100 ARG A N   1 ? 
ATOM   573  C CA  . ARG A 1 77  ? 1.696   28.179  28.912 1.00 22.32  ? 100 ARG A CA  1 ? 
ATOM   574  C C   . ARG A 1 77  ? 3.043   28.916  29.003 1.00 25.66  ? 100 ARG A C   1 ? 
ATOM   575  O O   . ARG A 1 77  ? 3.476   29.443  27.987 1.00 24.81  ? 100 ARG A O   1 ? 
ATOM   576  C CB  . ARG A 1 77  ? 0.605   29.068  28.316 1.00 29.21  ? 100 ARG A CB  1 ? 
ATOM   577  C CG  . ARG A 1 77  ? -0.082  28.412  27.131 1.00 42.46  ? 100 ARG A CG  1 ? 
ATOM   578  C CD  . ARG A 1 77  ? -1.243  27.537  27.530 1.00 39.17  ? 100 ARG A CD  1 ? 
ATOM   579  N NE  . ARG A 1 77  ? -1.917  27.047  26.325 1.00 52.62  ? 100 ARG A NE  1 ? 
ATOM   580  C CZ  . ARG A 1 77  ? -3.138  26.539  26.296 1.00 75.45  ? 100 ARG A CZ  1 ? 
ATOM   581  N NH1 . ARG A 1 77  ? -3.377  25.359  26.837 1.00 56.76  ? 100 ARG A NH1 1 ? 
ATOM   582  N NH2 . ARG A 1 77  ? -4.118  27.222  25.731 1.00 83.06  ? 100 ARG A NH2 1 ? 
ATOM   583  N N   . LYS A 1 78  ? 3.662   28.929  30.185 1.00 16.59  ? 101 LYS A N   1 ? 
ATOM   584  C CA  . LYS A 1 78  ? 4.940   29.661  30.350 1.00 18.32  ? 101 LYS A CA  1 ? 
ATOM   585  C C   . LYS A 1 78  ? 6.096   28.846  29.741 1.00 20.27  ? 101 LYS A C   1 ? 
ATOM   586  O O   . LYS A 1 78  ? 7.020   29.469  29.221 1.00 19.46  ? 101 LYS A O   1 ? 
ATOM   587  C CB  . LYS A 1 78  ? 5.188   29.998  31.823 1.00 19.06  ? 101 LYS A CB  1 ? 
ATOM   588  C CG  . LYS A 1 78  ? 4.221   31.011  32.400 1.00 22.28  ? 101 LYS A CG  1 ? 
ATOM   589  C CD  . LYS A 1 78  ? 4.428   32.389  31.786 1.00 21.38  ? 101 LYS A CD  1 ? 
ATOM   590  C CE  . LYS A 1 78  ? 3.666   33.445  32.510 1.00 24.85  ? 101 LYS A CE  1 ? 
ATOM   591  N NZ  . LYS A 1 78  ? 3.821   34.748  31.863 1.00 26.94  ? 101 LYS A NZ  1 ? 
ATOM   592  N N   . VAL A 1 79  ? 6.012   27.513  29.782 1.00 19.09  ? 102 VAL A N   1 ? 
ATOM   593  C CA  . VAL A 1 79  ? 7.126   26.635  29.314 1.00 18.46  ? 102 VAL A CA  1 ? 
ATOM   594  C C   . VAL A 1 79  ? 7.158   26.645  27.776 1.00 18.85  ? 102 VAL A C   1 ? 
ATOM   595  O O   . VAL A 1 79  ? 8.168   26.239  27.215 1.00 22.37  ? 102 VAL A O   1 ? 
ATOM   596  C CB  . VAL A 1 79  ? 6.979   25.239  29.960 1.00 20.21  ? 102 VAL A CB  1 ? 
ATOM   597  C CG1 . VAL A 1 79  ? 8.065   24.261  29.552 1.00 21.54  ? 102 VAL A CG1 1 ? 
ATOM   598  C CG2 . VAL A 1 79  ? 6.927   25.351  31.478 1.00 18.42  ? 102 VAL A CG2 1 ? 
ATOM   599  N N   . GLN A 1 80  ? 6.106   27.145  27.140 1.00 18.34  ? 103 GLN A N   1 ? 
ATOM   600  C CA  . GLN A 1 80  ? 6.076   27.314  25.663 1.00 24.79  ? 103 GLN A CA  1 ? 
ATOM   601  C C   . GLN A 1 80  ? 7.313   28.080  25.166 1.00 20.72  ? 103 GLN A C   1 ? 
ATOM   602  O O   . GLN A 1 80  ? 7.686   27.882  24.016 1.00 17.43  ? 103 GLN A O   1 ? 
ATOM   603  C CB  . GLN A 1 80  ? 4.885   28.173  25.227 1.00 22.59  ? 103 GLN A CB  1 ? 
ATOM   604  C CG  . GLN A 1 80  ? 3.527   27.513  25.386 1.00 27.59  ? 103 GLN A CG  1 ? 
ATOM   605  C CD  . GLN A 1 80  ? 2.444   28.269  24.656 1.00 22.58  ? 103 GLN A CD  1 ? 
ATOM   606  O OE1 . GLN A 1 80  ? 2.341   29.497  24.737 1.00 20.64  ? 103 GLN A OE1 1 ? 
ATOM   607  N NE2 . GLN A 1 80  ? 1.633   27.527  23.925 1.00 25.56  ? 103 GLN A NE2 1 ? 
ATOM   608  N N   . ILE A 1 81  ? 7.878   28.943  26.003 1.00 17.25  ? 104 ILE A N   1 ? 
ATOM   609  C CA  . ILE A 1 81  ? 9.115   29.699  25.646 1.00 22.95  ? 104 ILE A CA  1 ? 
ATOM   610  C C   . ILE A 1 81  ? 10.179  28.757  25.051 1.00 19.39  ? 104 ILE A C   1 ? 
ATOM   611  O O   . ILE A 1 81  ? 10.841  29.158  24.102 1.00 20.25  ? 104 ILE A O   1 ? 
ATOM   612  C CB  . ILE A 1 81  ? 9.663   30.438  26.882 1.00 23.33  ? 104 ILE A CB  1 ? 
ATOM   613  C CG1 . ILE A 1 81  ? 10.834  31.353  26.533 1.00 22.82  ? 104 ILE A CG1 1 ? 
ATOM   614  C CG2 . ILE A 1 81  ? 10.022  29.476  28.014 1.00 17.78  ? 104 ILE A CG2 1 ? 
ATOM   615  C CD1 . ILE A 1 81  ? 10.422  32.756  26.144 1.00 28.42  ? 104 ILE A CD1 1 ? 
ATOM   616  N N   . PHE A 1 82  ? 10.306  27.549  25.583 1.00 15.58  ? 105 PHE A N   1 ? 
ATOM   617  C CA  . PHE A 1 82  ? 11.371  26.623  25.138 1.00 17.52  ? 105 PHE A CA  1 ? 
ATOM   618  C C   . PHE A 1 82  ? 11.123  26.133  23.714 1.00 20.28  ? 105 PHE A C   1 ? 
ATOM   619  O O   . PHE A 1 82  ? 12.055  25.570  23.140 1.00 21.47  ? 105 PHE A O   1 ? 
ATOM   620  C CB  . PHE A 1 82  ? 11.425  25.483  26.155 1.00 16.23  ? 105 PHE A CB  1 ? 
ATOM   621  C CG  . PHE A 1 82  ? 12.010  25.851  27.509 1.00 15.34  ? 105 PHE A CG  1 ? 
ATOM   622  C CD1 . PHE A 1 82  ? 13.355  26.167  27.641 1.00 16.39  ? 105 PHE A CD1 1 ? 
ATOM   623  C CD2 . PHE A 1 82  ? 11.219  25.858  28.651 1.00 14.95  ? 105 PHE A CD2 1 ? 
ATOM   624  C CE1 . PHE A 1 82  ? 13.886  26.490  28.877 1.00 17.33  ? 105 PHE A CE1 1 ? 
ATOM   625  C CE2 . PHE A 1 82  ? 11.757  26.182  29.883 1.00 15.33  ? 105 PHE A CE2 1 ? 
ATOM   626  C CZ  . PHE A 1 82  ? 13.089  26.492  29.994 1.00 14.24  ? 105 PHE A CZ  1 ? 
ATOM   627  N N   . ASP A 1 83  ? 9.926   26.352  23.177 1.00 17.59  ? 106 ASP A N   1 ? 
ATOM   628  C CA  . ASP A 1 83  ? 9.556   25.817  21.841 1.00 16.09  ? 106 ASP A CA  1 ? 
ATOM   629  C C   . ASP A 1 83  ? 9.723   26.853  20.730 1.00 17.24  ? 106 ASP A C   1 ? 
ATOM   630  O O   . ASP A 1 83  ? 9.669   26.474  19.560 1.00 17.53  ? 106 ASP A O   1 ? 
ATOM   631  C CB  . ASP A 1 83  ? 8.127   25.333  21.811 1.00 21.41  ? 106 ASP A CB  1 ? 
ATOM   632  C CG  . ASP A 1 83  ? 7.926   23.886  22.222 1.00 28.49  ? 106 ASP A CG  1 ? 
ATOM   633  O OD1 . ASP A 1 83  ? 8.934   23.155  22.271 1.00 27.49  ? 106 ASP A OD1 1 ? 
ATOM   634  O OD2 . ASP A 1 83  ? 6.767   23.516  22.476 1.00 29.35  ? 106 ASP A OD2 1 ? 
ATOM   635  N N   . LEU A 1 84  ? 9.880   28.108  21.114 1.00 15.18  ? 107 LEU A N   1 ? 
ATOM   636  C CA  . LEU A 1 84  ? 9.980   29.167  20.090 1.00 15.48  ? 107 LEU A CA  1 ? 
ATOM   637  C C   . LEU A 1 84  ? 11.194  28.892  19.186 1.00 15.04  ? 107 LEU A C   1 ? 
ATOM   638  O O   . LEU A 1 84  ? 12.299  28.754  19.676 1.00 16.21  ? 107 LEU A O   1 ? 
ATOM   639  C CB  . LEU A 1 84  ? 10.030  30.526  20.779 1.00 18.46  ? 107 LEU A CB  1 ? 
ATOM   640  C CG  . LEU A 1 84  ? 8.748   30.963  21.493 1.00 19.72  ? 107 LEU A CG  1 ? 
ATOM   641  C CD1 . LEU A 1 84  ? 8.869   32.407  21.922 1.00 21.78  ? 107 LEU A CD1 1 ? 
ATOM   642  C CD2 . LEU A 1 84  ? 7.520   30.770  20.624 1.00 20.76  ? 107 LEU A CD2 1 ? 
ATOM   643  N N   . PRO A 1 85  ? 10.991  28.814  17.858 1.00 20.06  ? 108 PRO A N   1 ? 
ATOM   644  C CA  . PRO A 1 85  ? 12.088  28.512  16.959 1.00 16.04  ? 108 PRO A CA  1 ? 
ATOM   645  C C   . PRO A 1 85  ? 13.184  29.567  16.927 1.00 16.63  ? 108 PRO A C   1 ? 
ATOM   646  O O   . PRO A 1 85  ? 12.841  30.748  16.901 1.00 17.28  ? 108 PRO A O   1 ? 
ATOM   647  C CB  . PRO A 1 85  ? 11.395  28.330  15.596 1.00 16.15  ? 108 PRO A CB  1 ? 
ATOM   648  C CG  . PRO A 1 85  ? 10.094  29.075  15.735 1.00 15.26  ? 108 PRO A CG  1 ? 
ATOM   649  C CD  . PRO A 1 85  ? 9.715   28.950  17.195 1.00 14.62  ? 108 PRO A CD  1 ? 
ATOM   650  N N   . PHE A 1 86  ? 14.442  29.128  16.999 1.00 16.72  ? 109 PHE A N   1 ? 
ATOM   651  C CA  . PHE A 1 86  ? 15.627  30.021  16.904 1.00 20.31  ? 109 PHE A CA  1 ? 
ATOM   652  C C   . PHE A 1 86  ? 15.754  30.958  18.105 1.00 26.25  ? 109 PHE A C   1 ? 
ATOM   653  O O   . PHE A 1 86  ? 16.584  31.865  18.057 1.00 29.22  ? 109 PHE A O   1 ? 
ATOM   654  C CB  . PHE A 1 86  ? 15.604  30.770  15.575 1.00 21.84  ? 109 PHE A CB  1 ? 
ATOM   655  C CG  . PHE A 1 86  ? 15.762  29.881  14.353 1.00 21.71  ? 109 PHE A CG  1 ? 
ATOM   656  C CD1 . PHE A 1 86  ? 17.008  29.401  13.980 1.00 24.36  ? 109 PHE A CD1 1 ? 
ATOM   657  C CD2 . PHE A 1 86  ? 14.664  29.535  13.580 1.00 24.70  ? 109 PHE A CD2 1 ? 
ATOM   658  C CE1 . PHE A 1 86  ? 17.148  28.603  12.858 1.00 23.99  ? 109 PHE A CE1 1 ? 
ATOM   659  C CE2 . PHE A 1 86  ? 14.812  28.728  12.468 1.00 20.53  ? 109 PHE A CE2 1 ? 
ATOM   660  C CZ  . PHE A 1 86  ? 16.052  28.271  12.106 1.00 21.47  ? 109 PHE A CZ  1 ? 
ATOM   661  N N   . LEU A 1 87  ? 14.964  30.743  19.144 1.00 21.51  ? 110 LEU A N   1 ? 
ATOM   662  C CA  . LEU A 1 87  ? 15.149  31.563  20.363 1.00 21.98  ? 110 LEU A CA  1 ? 
ATOM   663  C C   . LEU A 1 87  ? 16.549  31.313  20.942 1.00 22.51  ? 110 LEU A C   1 ? 
ATOM   664  O O   . LEU A 1 87  ? 17.249  32.279  21.234 1.00 20.31  ? 110 LEU A O   1 ? 
ATOM   665  C CB  . LEU A 1 87  ? 14.080  31.217  21.393 1.00 20.14  ? 110 LEU A CB  1 ? 
ATOM   666  C CG  . LEU A 1 87  ? 14.124  32.016  22.698 1.00 18.72  ? 110 LEU A CG  1 ? 
ATOM   667  C CD1 . LEU A 1 87  ? 14.250  33.508  22.460 1.00 18.70  ? 110 LEU A CD1 1 ? 
ATOM   668  C CD2 . LEU A 1 87  ? 12.890  31.713  23.508 1.00 19.32  ? 110 LEU A CD2 1 ? 
ATOM   669  N N   . PHE A 1 88  ? 16.894  30.049  21.133 1.00 16.82  ? 111 PHE A N   1 ? 
ATOM   670  C CA  . PHE A 1 88  ? 18.187  29.694  21.761 1.00 18.28  ? 111 PHE A CA  1 ? 
ATOM   671  C C   . PHE A 1 88  ? 19.186  29.267  20.682 1.00 23.76  ? 111 PHE A C   1 ? 
ATOM   672  O O   . PHE A 1 88  ? 18.878  28.388  19.875 1.00 20.84  ? 111 PHE A O   1 ? 
ATOM   673  C CB  . PHE A 1 88  ? 17.983  28.612  22.820 1.00 18.81  ? 111 PHE A CB  1 ? 
ATOM   674  C CG  . PHE A 1 88  ? 16.990  28.982  23.909 1.00 21.49  ? 111 PHE A CG  1 ? 
ATOM   675  C CD1 . PHE A 1 88  ? 17.362  29.809  24.959 1.00 19.58  ? 111 PHE A CD1 1 ? 
ATOM   676  C CD2 . PHE A 1 88  ? 15.688  28.498  23.878 1.00 23.46  ? 111 PHE A CD2 1 ? 
ATOM   677  C CE1 . PHE A 1 88  ? 16.455  30.136  25.950 1.00 21.58  ? 111 PHE A CE1 1 ? 
ATOM   678  C CE2 . PHE A 1 88  ? 14.788  28.831  24.873 1.00 24.13  ? 111 PHE A CE2 1 ? 
ATOM   679  C CZ  . PHE A 1 88  ? 15.173  29.649  25.903 1.00 21.05  ? 111 PHE A CZ  1 ? 
ATOM   680  N N   . ASP A 1 89  ? 20.354  29.901  20.690 1.00 21.19  ? 112 ASP A N   1 ? 
ATOM   681  C CA  . ASP A 1 89  ? 21.395  29.597  19.681 1.00 19.80  ? 112 ASP A CA  1 ? 
ATOM   682  C C   . ASP A 1 89  ? 21.867  28.163  19.869 1.00 23.48  ? 112 ASP A C   1 ? 
ATOM   683  O O   . ASP A 1 89  ? 22.178  27.502  18.880 1.00 19.33  ? 112 ASP A O   1 ? 
ATOM   684  C CB  . ASP A 1 89  ? 22.565  30.556  19.815 1.00 21.14  ? 112 ASP A CB  1 ? 
ATOM   685  C CG  . ASP A 1 89  ? 22.251  31.990  19.426 1.00 26.13  ? 112 ASP A CG  1 ? 
ATOM   686  O OD1 . ASP A 1 89  ? 21.198  32.196  18.797 1.00 27.20  ? 112 ASP A OD1 1 ? 
ATOM   687  O OD2 . ASP A 1 89  ? 23.056  32.874  19.769 1.00 29.98  ? 112 ASP A OD2 1 ? 
ATOM   688  N N   . ASP A 1 90  ? 21.933  27.735  21.126 1.00 20.47  ? 113 ASP A N   1 ? 
ATOM   689  C CA  . ASP A 1 90  ? 22.473  26.384  21.407 1.00 19.57  ? 113 ASP A CA  1 ? 
ATOM   690  C C   . ASP A 1 90  ? 22.085  25.931  22.812 1.00 16.70  ? 113 ASP A C   1 ? 
ATOM   691  O O   . ASP A 1 90  ? 21.402  26.683  23.500 1.00 19.34  ? 113 ASP A O   1 ? 
ATOM   692  C CB  . ASP A 1 90  ? 23.977  26.363  21.260 1.00 23.79  ? 113 ASP A CB  1 ? 
ATOM   693  C CG  . ASP A 1 90  ? 24.718  27.527  21.901 1.00 27.82  ? 113 ASP A CG  1 ? 
ATOM   694  O OD1 . ASP A 1 90  ? 24.242  28.029  22.931 1.00 24.86  ? 113 ASP A OD1 1 ? 
ATOM   695  O OD2 . ASP A 1 90  ? 25.772  27.910  21.363 1.00 29.24  ? 113 ASP A OD2 1 ? 
ATOM   696  N N   . ILE A 1 91  ? 22.556  24.751  23.210 1.00 15.58  ? 114 ILE A N   1 ? 
ATOM   697  C CA  . ILE A 1 91  ? 22.146  24.197  24.531 1.00 17.68  ? 114 ILE A CA  1 ? 
ATOM   698  C C   . ILE A 1 91  ? 22.816  25.012  25.654 1.00 20.14  ? 114 ILE A C   1 ? 
ATOM   699  O O   . ILE A 1 91  ? 22.244  25.091  26.743 1.00 22.50  ? 114 ILE A O   1 ? 
ATOM   700  C CB  . ILE A 1 91  ? 22.426  22.686  24.606 1.00 18.37  ? 114 ILE A CB  1 ? 
ATOM   701  C CG1 . ILE A 1 91  ? 21.557  21.922  23.617 1.00 18.15  ? 114 ILE A CG1 1 ? 
ATOM   702  C CG2 . ILE A 1 91  ? 22.252  22.147  26.023 1.00 16.49  ? 114 ILE A CG2 1 ? 
ATOM   703  C CD1 . ILE A 1 91  ? 20.069  22.108  23.843 1.00 22.78  ? 114 ILE A CD1 1 ? 
ATOM   704  N N   . GLN A 1 92  ? 23.962  25.629  25.374 1.00 19.01  ? 115 GLN A N   1 ? 
ATOM   705  C CA  . GLN A 1 92  ? 24.625  26.492  26.386 1.00 19.99  ? 115 GLN A CA  1 ? 
ATOM   706  C C   . GLN A 1 92  ? 23.716  27.695  26.711 1.00 19.01  ? 115 GLN A C   1 ? 
ATOM   707  O O   . GLN A 1 92  ? 23.613  28.065  27.876 1.00 17.80  ? 115 GLN A O   1 ? 
ATOM   708  C CB  . GLN A 1 92  ? 26.010  26.891  25.887 1.00 24.32  ? 115 GLN A CB  1 ? 
ATOM   709  C CG  . GLN A 1 92  ? 26.935  25.712  25.607 1.00 34.09  ? 115 GLN A CG  1 ? 
ATOM   710  C CD  . GLN A 1 92  ? 26.965  25.276  24.158 1.00 52.26  ? 115 GLN A CD  1 ? 
ATOM   711  O OE1 . GLN A 1 92  ? 25.935  24.992  23.540 1.00 42.67  ? 115 GLN A OE1 1 ? 
ATOM   712  N NE2 . GLN A 1 92  ? 28.164  25.190  23.602 1.00 62.70  ? 115 GLN A NE2 1 ? 
ATOM   713  N N   . ALA A 1 93  ? 23.083  28.257  25.690 1.00 16.28  ? 116 ALA A N   1 ? 
ATOM   714  C CA  . ALA A 1 93  ? 22.142  29.375  25.919 1.00 15.69  ? 116 ALA A CA  1 ? 
ATOM   715  C C   . ALA A 1 93  ? 20.936  28.892  26.736 1.00 21.07  ? 116 ALA A C   1 ? 
ATOM   716  O O   . ALA A 1 93  ? 20.571  29.531  27.718 1.00 23.05  ? 116 ALA A O   1 ? 
ATOM   717  C CB  . ALA A 1 93  ? 21.734  29.999  24.610 1.00 20.38  ? 116 ALA A CB  1 ? 
ATOM   718  N N   . VAL A 1 94  ? 20.353  27.764  26.341 1.00 23.66  ? 117 VAL A N   1 ? 
ATOM   719  C CA  . VAL A 1 94  ? 19.140  27.265  27.057 1.00 19.28  ? 117 VAL A CA  1 ? 
ATOM   720  C C   . VAL A 1 94  ? 19.548  27.015  28.521 1.00 18.72  ? 117 VAL A C   1 ? 
ATOM   721  O O   . VAL A 1 94  ? 18.780  27.388  29.405 1.00 18.26  ? 117 VAL A O   1 ? 
ATOM   722  C CB  . VAL A 1 94  ? 18.427  26.047  26.423 1.00 19.73  ? 117 VAL A CB  1 ? 
ATOM   723  C CG1 . VAL A 1 94  ? 19.107  24.720  26.715 1.00 17.55  ? 117 VAL A CG1 1 ? 
ATOM   724  C CG2 . VAL A 1 94  ? 16.964  25.991  26.834 1.00 21.78  ? 117 VAL A CG2 1 ? 
ATOM   725  N N   . ASP A 1 95  ? 20.728  26.432  28.736 1.00 19.47  ? 118 ASP A N   1 ? 
ATOM   726  C CA  . ASP A 1 95  ? 21.213  26.115  30.104 1.00 18.55  ? 118 ASP A CA  1 ? 
ATOM   727  C C   . ASP A 1 95  ? 21.254  27.403  30.922 1.00 19.41  ? 118 ASP A C   1 ? 
ATOM   728  O O   . ASP A 1 95  ? 20.821  27.399  32.066 1.00 24.40  ? 118 ASP A O   1 ? 
ATOM   729  C CB  . ASP A 1 95  ? 22.556  25.410  30.052 1.00 18.88  ? 118 ASP A CB  1 ? 
ATOM   730  C CG  . ASP A 1 95  ? 23.092  24.932  31.389 1.00 20.97  ? 118 ASP A CG  1 ? 
ATOM   731  O OD1 . ASP A 1 95  ? 22.564  23.934  31.897 1.00 21.27  ? 118 ASP A OD1 1 ? 
ATOM   732  O OD2 . ASP A 1 95  ? 24.025  25.567  31.902 1.00 19.82  ? 118 ASP A OD2 1 ? 
ATOM   733  N N   . ARG A 1 96  ? 21.743  28.467  30.307 1.00 19.24  ? 119 ARG A N   1 ? 
ATOM   734  C CA  . ARG A 1 96  ? 21.826  29.768  31.003 1.00 19.61  ? 119 ARG A CA  1 ? 
ATOM   735  C C   . ARG A 1 96  ? 20.413  30.228  31.399 1.00 20.38  ? 119 ARG A C   1 ? 
ATOM   736  O O   . ARG A 1 96  ? 20.236  30.647  32.532 1.00 19.06  ? 119 ARG A O   1 ? 
ATOM   737  C CB  . ARG A 1 96  ? 22.580  30.785  30.143 1.00 21.61  ? 119 ARG A CB  1 ? 
ATOM   738  C CG  . ARG A 1 96  ? 24.084  30.574  30.201 1.00 26.56  ? 119 ARG A CG  1 ? 
ATOM   739  C CD  . ARG A 1 96  ? 24.861  31.734  29.613 1.00 27.42  ? 119 ARG A CD  1 ? 
ATOM   740  N NE  . ARG A 1 96  ? 24.700  31.819  28.160 1.00 28.53  ? 119 ARG A NE  1 ? 
ATOM   741  C CZ  . ARG A 1 96  ? 25.507  31.279  27.258 1.00 26.26  ? 119 ARG A CZ  1 ? 
ATOM   742  N NH1 . ARG A 1 96  ? 26.517  30.519  27.631 1.00 27.41  ? 119 ARG A NH1 1 ? 
ATOM   743  N NH2 . ARG A 1 96  ? 25.293  31.500  25.979 1.00 22.88  ? 119 ARG A NH2 1 ? 
ATOM   744  N N   . PHE A 1 97  ? 19.471  30.147  30.462 1.00 21.58  ? 120 PHE A N   1 ? 
ATOM   745  C CA  . PHE A 1 97  ? 18.074  30.567  30.760 1.00 22.17  ? 120 PHE A CA  1 ? 
ATOM   746  C C   . PHE A 1 97  ? 17.527  29.710  31.922 1.00 16.80  ? 120 PHE A C   1 ? 
ATOM   747  O O   . PHE A 1 97  ? 16.994  30.225  32.890 1.00 16.13  ? 120 PHE A O   1 ? 
ATOM   748  C CB  . PHE A 1 97  ? 17.228  30.469  29.493 1.00 21.70  ? 120 PHE A CB  1 ? 
ATOM   749  C CG  . PHE A 1 97  ? 15.760  30.778  29.730 1.00 20.05  ? 120 PHE A CG  1 ? 
ATOM   750  C CD1 . PHE A 1 97  ? 15.357  32.048  30.121 1.00 22.96  ? 120 PHE A CD1 1 ? 
ATOM   751  C CD2 . PHE A 1 97  ? 14.792  29.794  29.584 1.00 19.42  ? 120 PHE A CD2 1 ? 
ATOM   752  C CE1 . PHE A 1 97  ? 14.021  32.328  30.338 1.00 17.92  ? 120 PHE A CE1 1 ? 
ATOM   753  C CE2 . PHE A 1 97  ? 13.459  30.081  29.803 1.00 16.22  ? 120 PHE A CE2 1 ? 
ATOM   754  C CZ  . PHE A 1 97  ? 13.078  31.343  30.182 1.00 19.60  ? 120 PHE A CZ  1 ? 
ATOM   755  N N   . GLN A 1 98  ? 17.703  28.406  31.804 1.00 12.66  ? 121 GLN A N   1 ? 
ATOM   756  C CA  . GLN A 1 98  ? 17.224  27.469  32.851 1.00 14.63  ? 121 GLN A CA  1 ? 
ATOM   757  C C   . GLN A 1 98  ? 17.816  27.808  34.239 1.00 16.32  ? 121 GLN A C   1 ? 
ATOM   758  O O   . GLN A 1 98  ? 17.142  27.579  35.229 1.00 13.92  ? 121 GLN A O   1 ? 
ATOM   759  C CB  . GLN A 1 98  ? 17.561  26.061  32.364 1.00 17.70  ? 121 GLN A CB  1 ? 
ATOM   760  C CG  . GLN A 1 98  ? 16.767  25.638  31.133 1.00 14.61  ? 121 GLN A CG  1 ? 
ATOM   761  C CD  . GLN A 1 98  ? 17.232  24.337  30.516 1.00 17.55  ? 121 GLN A CD  1 ? 
ATOM   762  O OE1 . GLN A 1 98  ? 18.335  23.854  30.778 1.00 17.45  ? 121 GLN A OE1 1 ? 
ATOM   763  N NE2 . GLN A 1 98  ? 16.384  23.752  29.687 1.00 17.80  ? 121 GLN A NE2 1 ? 
ATOM   764  N N   . ARG A 1 99  ? 19.024  28.365  34.275 1.00 19.07  ? 122 ARG A N   1 ? 
ATOM   765  C CA  . ARG A 1 99  ? 19.707  28.680  35.566 1.00 18.52  ? 122 ARG A CA  1 ? 
ATOM   766  C C   . ARG A 1 99  ? 19.333  30.091  36.057 1.00 18.30  ? 122 ARG A C   1 ? 
ATOM   767  O O   . ARG A 1 99  ? 19.703  30.441  37.174 1.00 20.75  ? 122 ARG A O   1 ? 
ATOM   768  C CB  . ARG A 1 99  ? 21.211  28.485  35.383 1.00 14.91  ? 122 ARG A CB  1 ? 
ATOM   769  C CG  . ARG A 1 99  ? 21.680  27.045  35.265 1.00 17.76  ? 122 ARG A CG  1 ? 
ATOM   770  C CD  . ARG A 1 99  ? 23.106  27.050  34.758 1.00 26.00  ? 122 ARG A CD  1 ? 
ATOM   771  N NE  . ARG A 1 99  ? 23.763  25.759  34.965 1.00 37.68  ? 122 ARG A NE  1 ? 
ATOM   772  C CZ  . ARG A 1 99  ? 24.397  25.404  36.073 1.00 58.34  ? 122 ARG A CZ  1 ? 
ATOM   773  N NH1 . ARG A 1 99  ? 24.373  26.182  37.140 1.00 60.74  ? 122 ARG A NH1 1 ? 
ATOM   774  N NH2 . ARG A 1 99  ? 25.063  24.267  36.110 1.00 55.77  ? 122 ARG A NH2 1 ? 
ATOM   775  N N   . SER A 1 100 ? 18.670  30.873  35.218 1.00 18.03  ? 123 SER A N   1 ? 
ATOM   776  C CA  . SER A 1 100 ? 18.177  32.214  35.601 1.00 18.14  ? 123 SER A CA  1 ? 
ATOM   777  C C   . SER A 1 100 ? 17.113  32.091  36.702 1.00 19.40  ? 123 SER A C   1 ? 
ATOM   778  O O   . SER A 1 100 ? 16.506  31.038  36.834 1.00 17.96  ? 123 SER A O   1 ? 
ATOM   779  C CB  . SER A 1 100 ? 17.578  32.900  34.410 1.00 17.75  ? 123 SER A CB  1 ? 
ATOM   780  O OG  . SER A 1 100 ? 16.301  32.382  34.089 1.00 21.81  ? 123 SER A OG  1 ? 
ATOM   781  N N   . PRO A 1 101 ? 16.846  33.164  37.477 1.00 18.35  ? 124 PRO A N   1 ? 
ATOM   782  C CA  . PRO A 1 101 ? 15.773  33.108  38.454 1.00 23.03  ? 124 PRO A CA  1 ? 
ATOM   783  C C   . PRO A 1 101 ? 14.471  32.680  37.789 1.00 18.10  ? 124 PRO A C   1 ? 
ATOM   784  O O   . PRO A 1 101 ? 13.763  31.837  38.326 1.00 18.91  ? 124 PRO A O   1 ? 
ATOM   785  C CB  . PRO A 1 101 ? 15.726  34.542  38.985 1.00 17.74  ? 124 PRO A CB  1 ? 
ATOM   786  C CG  . PRO A 1 101 ? 17.135  35.039  38.784 1.00 19.04  ? 124 PRO A CG  1 ? 
ATOM   787  C CD  . PRO A 1 101 ? 17.568  34.419  37.470 1.00 20.54  ? 124 PRO A CD  1 ? 
ATOM   788  N N   . GLN A 1 102 ? 14.175  33.273  36.636 1.00 16.78  ? 125 GLN A N   1 ? 
ATOM   789  C CA  . GLN A 1 102 ? 12.954  32.918  35.876 1.00 19.47  ? 125 GLN A CA  1 ? 
ATOM   790  C C   . GLN A 1 102 ? 12.962  31.434  35.473 1.00 18.70  ? 125 GLN A C   1 ? 
ATOM   791  O O   . GLN A 1 102 ? 11.943  30.765  35.660 1.00 17.74  ? 125 GLN A O   1 ? 
ATOM   792  C CB  . GLN A 1 102 ? 12.842  33.817  34.652 1.00 17.93  ? 125 GLN A CB  1 ? 
ATOM   793  C CG  . GLN A 1 102 ? 12.644  35.286  34.994 1.00 19.03  ? 125 GLN A CG  1 ? 
ATOM   794  C CD  . GLN A 1 102 ? 13.923  36.083  34.907 1.00 19.13  ? 125 GLN A CD  1 ? 
ATOM   795  O OE1 . GLN A 1 102 ? 14.995  35.620  35.304 1.00 21.56  ? 125 GLN A OE1 1 ? 
ATOM   796  N NE2 . GLN A 1 102 ? 13.813  37.293  34.384 1.00 19.18  ? 125 GLN A NE2 1 ? 
ATOM   797  N N   . GLY A 1 103 ? 14.077  30.972  34.922 1.00 17.73  ? 126 GLY A N   1 ? 
ATOM   798  C CA  . GLY A 1 103 ? 14.154  29.581  34.465 1.00 19.21  ? 126 GLY A CA  1 ? 
ATOM   799  C C   . GLY A 1 103 ? 13.947  28.643  35.632 1.00 18.14  ? 126 GLY A C   1 ? 
ATOM   800  O O   . GLY A 1 103 ? 13.214  27.664  35.478 1.00 24.68  ? 126 GLY A O   1 ? 
ATOM   801  N N   . ARG A 1 104 ? 14.549  28.962  36.771 1.00 17.72  ? 127 ARG A N   1 ? 
ATOM   802  C CA  . ARG A 1 104 ? 14.385  28.117  37.982 1.00 19.59  ? 127 ARG A CA  1 ? 
ATOM   803  C C   . ARG A 1 104 ? 12.915  28.145  38.435 1.00 17.76  ? 127 ARG A C   1 ? 
ATOM   804  O O   . ARG A 1 104 ? 12.395  27.102  38.814 1.00 16.77  ? 127 ARG A O   1 ? 
ATOM   805  C CB  . ARG A 1 104 ? 15.323  28.556  39.106 1.00 22.24  ? 127 ARG A CB  1 ? 
ATOM   806  C CG  . ARG A 1 104 ? 16.794  28.311  38.805 1.00 32.22  ? 127 ARG A CG  1 ? 
ATOM   807  C CD  . ARG A 1 104 ? 17.070  26.885  38.365 1.00 37.65  ? 127 ARG A CD  1 ? 
ATOM   808  N NE  . ARG A 1 104 ? 17.130  25.934  39.481 1.00 42.40  ? 127 ARG A NE  1 ? 
ATOM   809  C CZ  . ARG A 1 104 ? 17.236  24.618  39.356 1.00 42.01  ? 127 ARG A CZ  1 ? 
ATOM   810  N NH1 . ARG A 1 104 ? 17.570  24.080  38.200 1.00 39.21  ? 127 ARG A NH1 1 ? 
ATOM   811  N NH2 . ARG A 1 104 ? 17.003  23.840  40.394 1.00 46.04  ? 127 ARG A NH2 1 ? 
ATOM   812  N N   . ALA A 1 105 ? 12.287  29.310  38.344 1.00 15.49  ? 128 ALA A N   1 ? 
ATOM   813  C CA  . ALA A 1 105 ? 10.892  29.455  38.806 1.00 16.34  ? 128 ALA A CA  1 ? 
ATOM   814  C C   . ALA A 1 105 ? 9.966   28.556  37.984 1.00 16.79  ? 128 ALA A C   1 ? 
ATOM   815  O O   . ALA A 1 105 ? 8.941   28.125  38.512 1.00 17.33  ? 128 ALA A O   1 ? 
ATOM   816  C CB  . ALA A 1 105 ? 10.485  30.896  38.704 1.00 13.78  ? 128 ALA A CB  1 ? 
ATOM   817  N N   . LEU A 1 106 ? 10.333  28.295  36.729 1.00 17.44  ? 129 LEU A N   1 ? 
ATOM   818  C CA  . LEU A 1 106 ? 9.447   27.517  35.828 1.00 18.08  ? 129 LEU A CA  1 ? 
ATOM   819  C C   . LEU A 1 106 ? 9.328   26.065  36.323 1.00 22.20  ? 129 LEU A C   1 ? 
ATOM   820  O O   . LEU A 1 106 ? 8.352   25.425  35.984 1.00 20.85  ? 129 LEU A O   1 ? 
ATOM   821  C CB  . LEU A 1 106 ? 9.970   27.597  34.400 1.00 19.13  ? 129 LEU A CB  1 ? 
ATOM   822  C CG  . LEU A 1 106 ? 9.840   28.961  33.720 1.00 19.07  ? 129 LEU A CG  1 ? 
ATOM   823  C CD1 . LEU A 1 106 ? 10.305  28.902  32.282 1.00 21.60  ? 129 LEU A CD1 1 ? 
ATOM   824  C CD2 . LEU A 1 106 ? 8.416   29.475  33.799 1.00 19.57  ? 129 LEU A CD2 1 ? 
ATOM   825  N N   . LEU A 1 107 ? 10.296  25.597  37.102 1.00 15.59  ? 130 LEU A N   1 ? 
ATOM   826  C CA  . LEU A 1 107 ? 10.192  24.242  37.699 1.00 18.46  ? 130 LEU A CA  1 ? 
ATOM   827  C C   . LEU A 1 107 ? 8.962   24.132  38.632 1.00 17.71  ? 130 LEU A C   1 ? 
ATOM   828  O O   . LEU A 1 107 ? 8.551   23.020  38.912 1.00 16.32  ? 130 LEU A O   1 ? 
ATOM   829  C CB  . LEU A 1 107 ? 11.499  23.970  38.428 1.00 18.02  ? 130 LEU A CB  1 ? 
ATOM   830  C CG  . LEU A 1 107 ? 12.750  23.828  37.556 1.00 17.82  ? 130 LEU A CG  1 ? 
ATOM   831  C CD1 . LEU A 1 107 ? 13.970  23.695  38.438 1.00 15.97  ? 130 LEU A CD1 1 ? 
ATOM   832  C CD2 . LEU A 1 107 ? 12.638  22.634  36.641 1.00 18.39  ? 130 LEU A CD2 1 ? 
ATOM   833  N N   . THR A 1 108 ? 8.409   25.261  39.086 1.00 16.37  ? 131 THR A N   1 ? 
ATOM   834  C CA  . THR A 1 108 ? 7.255   25.275  40.017 1.00 17.73  ? 131 THR A CA  1 ? 
ATOM   835  C C   . THR A 1 108 ? 6.020   25.834  39.312 1.00 18.11  ? 131 THR A C   1 ? 
ATOM   836  O O   . THR A 1 108 ? 5.002   25.977  39.969 1.00 16.59  ? 131 THR A O   1 ? 
ATOM   837  C CB  . THR A 1 108 ? 7.613   26.093  41.264 1.00 20.13  ? 131 THR A CB  1 ? 
ATOM   838  O OG1 . THR A 1 108 ? 8.007   27.387  40.825 1.00 26.28  ? 131 THR A OG1 1 ? 
ATOM   839  C CG2 . THR A 1 108 ? 8.723   25.456  42.076 1.00 27.70  ? 131 THR A CG2 1 ? 
ATOM   840  N N   . SER A 1 109 ? 6.115   26.091  38.008 1.00 19.00  ? 132 SER A N   1 ? 
ATOM   841  C CA  . SER A 1 109 ? 5.015   26.679  37.199 1.00 21.41  ? 132 SER A CA  1 ? 
ATOM   842  C C   . SER A 1 109 ? 3.747   25.817  37.241 1.00 27.93  ? 132 SER A C   1 ? 
ATOM   843  O O   . SER A 1 109 ? 2.674   26.362  36.995 1.00 24.25  ? 132 SER A O   1 ? 
ATOM   844  C CB  . SER A 1 109 ? 5.463   26.853  35.774 1.00 20.67  ? 132 SER A CB  1 ? 
ATOM   845  O OG  . SER A 1 109 ? 5.800   25.609  35.183 1.00 21.58  ? 132 SER A OG  1 ? 
ATOM   846  N N   . MET A 1 110 ? 3.888   24.531  37.542 1.00 20.92  ? 133 MET A N   1 ? 
ATOM   847  C CA  . MET A 1 110 ? 2.740   23.596  37.512 1.00 17.39  ? 133 MET A CA  1 ? 
ATOM   848  C C   . MET A 1 110 ? 2.433   23.040  38.918 1.00 18.23  ? 133 MET A C   1 ? 
ATOM   849  O O   . MET A 1 110 ? 1.635   22.117  39.005 1.00 16.80  ? 133 MET A O   1 ? 
ATOM   850  C CB  . MET A 1 110 ? 3.072   22.476  36.526 1.00 17.60  ? 133 MET A CB  1 ? 
ATOM   851  C CG  . MET A 1 110 ? 3.231   22.955  35.105 1.00 17.22  ? 133 MET A CG  1 ? 
ATOM   852  S SD  . MET A 1 110 ? 3.892   21.687  34.009 1.00 21.53  ? 133 MET A SD  1 ? 
ATOM   853  C CE  . MET A 1 110 ? 5.638   21.810  34.410 1.00 23.00  ? 133 MET A CE  1 ? 
ATOM   854  N N   . GLN A 1 111 ? 3.031   23.617  39.960 1.00 17.61  ? 134 GLN A N   1 ? 
ATOM   855  C CA  . GLN A 1 111 ? 2.840   23.124  41.350 1.00 19.17  ? 134 GLN A CA  1 ? 
ATOM   856  C C   . GLN A 1 111 ? 1.357   23.202  41.754 1.00 21.47  ? 134 GLN A C   1 ? 
ATOM   857  O O   . GLN A 1 111 ? 0.912   22.346  42.506 1.00 16.52  ? 134 GLN A O   1 ? 
ATOM   858  C CB  . GLN A 1 111 ? 3.709   23.949  42.294 1.00 25.55  ? 134 GLN A CB  1 ? 
ATOM   859  C CG  . GLN A 1 111 ? 3.727   23.434  43.727 1.00 34.92  ? 134 GLN A CG  1 ? 
ATOM   860  C CD  . GLN A 1 111 ? 5.077   23.558  44.398 1.00 41.14  ? 134 GLN A CD  1 ? 
ATOM   861  O OE1 . GLN A 1 111 ? 6.030   24.106  43.840 1.00 43.85  ? 134 GLN A OE1 1 ? 
ATOM   862  N NE2 . GLN A 1 111 ? 5.165   23.052  45.618 1.00 45.35  ? 134 GLN A NE2 1 ? 
ATOM   863  N N   . GLY A 1 112 ? 0.636   24.190  41.227 1.00 22.26  ? 135 GLY A N   1 ? 
ATOM   864  C CA  . GLY A 1 112 ? -0.803  24.347  41.501 1.00 23.45  ? 135 GLY A CA  1 ? 
ATOM   865  C C   . GLY A 1 112 ? -1.647  23.233  40.899 1.00 31.05  ? 135 GLY A C   1 ? 
ATOM   866  O O   . GLY A 1 112 ? -2.801  23.107  41.324 1.00 26.37  ? 135 GLY A O   1 ? 
ATOM   867  N N   . LYS A 1 113 ? -1.110  22.493  39.927 1.00 21.51  ? 136 LYS A N   1 ? 
ATOM   868  C CA  . LYS A 1 113 ? -1.807  21.330  39.330 1.00 19.73  ? 136 LYS A CA  1 ? 
ATOM   869  C C   . LYS A 1 113 ? -1.259  20.014  39.922 1.00 20.27  ? 136 LYS A C   1 ? 
ATOM   870  O O   . LYS A 1 113 ? -1.704  18.968  39.483 1.00 25.05  ? 136 LYS A O   1 ? 
ATOM   871  C CB  . LYS A 1 113 ? -1.653  21.380  37.811 1.00 20.62  ? 136 LYS A CB  1 ? 
ATOM   872  C CG  . LYS A 1 113 ? -1.758  22.749  37.175 1.00 23.87  ? 136 LYS A CG  1 ? 
ATOM   873  C CD  . LYS A 1 113 ? -2.988  22.864  36.288 1.00 25.45  ? 136 LYS A CD  1 ? 
ATOM   874  C CE  . LYS A 1 113 ? -3.225  24.250  35.784 1.00 30.88  ? 136 LYS A CE  1 ? 
ATOM   875  N NZ  . LYS A 1 113 ? -4.653  24.546  35.680 1.00 31.44  ? 136 LYS A NZ  1 ? 
ATOM   876  N N   . GLY A 1 114 ? -0.336  20.084  40.871 1.00 20.70  ? 137 GLY A N   1 ? 
ATOM   877  C CA  . GLY A 1 114 ? 0.182   18.882  41.551 1.00 17.31  ? 137 GLY A CA  1 ? 
ATOM   878  C C   . GLY A 1 114 ? 1.481   18.374  40.961 1.00 15.40  ? 137 GLY A C   1 ? 
ATOM   879  O O   . GLY A 1 114 ? 1.881   17.266  41.320 1.00 17.36  ? 137 GLY A O   1 ? 
ATOM   880  N N   . ILE A 1 115 ? 2.122   19.180  40.115 1.00 19.02  ? 138 ILE A N   1 ? 
ATOM   881  C CA  . ILE A 1 115 ? 3.385   18.771  39.428 1.00 18.67  ? 138 ILE A CA  1 ? 
ATOM   882  C C   . ILE A 1 115 ? 4.570   19.582  39.964 1.00 18.66  ? 138 ILE A C   1 ? 
ATOM   883  O O   . ILE A 1 115 ? 4.495   20.812  39.957 1.00 18.85  ? 138 ILE A O   1 ? 
ATOM   884  C CB  . ILE A 1 115 ? 3.272   18.905  37.896 1.00 19.84  ? 138 ILE A CB  1 ? 
ATOM   885  C CG1 . ILE A 1 115 ? 2.210   17.960  37.350 1.00 21.41  ? 138 ILE A CG1 1 ? 
ATOM   886  C CG2 . ILE A 1 115 ? 4.622   18.690  37.216 1.00 17.10  ? 138 ILE A CG2 1 ? 
ATOM   887  C CD1 . ILE A 1 115 ? 1.392   18.548  36.220 1.00 22.04  ? 138 ILE A CD1 1 ? 
ATOM   888  N N   . LEU A 1 116 ? 5.602   18.880  40.403 1.00 19.11  ? 139 LEU A N   1 ? 
ATOM   889  C CA  . LEU A 1 116 ? 6.820   19.535  40.925 1.00 16.95  ? 139 LEU A CA  1 ? 
ATOM   890  C C   . LEU A 1 116 ? 7.975   19.242  39.975 1.00 15.96  ? 139 LEU A C   1 ? 
ATOM   891  O O   . LEU A 1 116 ? 8.190   18.073  39.681 1.00 13.53  ? 139 LEU A O   1 ? 
ATOM   892  C CB  . LEU A 1 116 ? 7.160   19.024  42.318 1.00 21.59  ? 139 LEU A CB  1 ? 
ATOM   893  C CG  . LEU A 1 116 ? 8.217   19.804  43.098 1.00 25.80  ? 139 LEU A CG  1 ? 
ATOM   894  C CD1 . LEU A 1 116 ? 8.045   21.298  42.907 1.00 30.72  ? 139 LEU A CD1 1 ? 
ATOM   895  C CD2 . LEU A 1 116 ? 8.107   19.417  44.561 1.00 30.10  ? 139 LEU A CD2 1 ? 
ATOM   896  N N   . GLY A 1 117 ? 8.632   20.294  39.497 1.00 15.36  ? 140 GLY A N   1 ? 
ATOM   897  C CA  . GLY A 1 117 ? 9.836   20.121  38.679 1.00 14.45  ? 140 GLY A CA  1 ? 
ATOM   898  C C   . GLY A 1 117 ? 11.064  19.968  39.558 1.00 16.95  ? 140 GLY A C   1 ? 
ATOM   899  O O   . GLY A 1 117 ? 11.225  20.759  40.492 1.00 16.12  ? 140 GLY A O   1 ? 
ATOM   900  N N   . LEU A 1 118 ? 11.904  18.982  39.257 1.00 17.94  ? 141 LEU A N   1 ? 
ATOM   901  C CA  . LEU A 1 118 ? 13.076  18.697  40.125 1.00 20.42  ? 141 LEU A CA  1 ? 
ATOM   902  C C   . LEU A 1 118 ? 14.381  19.089  39.418 1.00 18.42  ? 141 LEU A C   1 ? 
ATOM   903  O O   . LEU A 1 118 ? 15.393  19.249  40.106 1.00 18.63  ? 141 LEU A O   1 ? 
ATOM   904  C CB  . LEU A 1 118 ? 13.091  17.218  40.495 1.00 16.27  ? 141 LEU A CB  1 ? 
ATOM   905  C CG  . LEU A 1 118 ? 11.824  16.652  41.138 1.00 20.29  ? 141 LEU A CG  1 ? 
ATOM   906  C CD1 . LEU A 1 118 ? 11.990  15.154  41.296 1.00 15.22  ? 141 LEU A CD1 1 ? 
ATOM   907  C CD2 . LEU A 1 118 ? 11.586  17.308  42.483 1.00 22.39  ? 141 LEU A CD2 1 ? 
ATOM   908  N N   . ALA A 1 119 ? 14.316  19.220  38.099 1.00 19.56  ? 142 ALA A N   1 ? 
ATOM   909  C CA  . ALA A 1 119 ? 15.529  19.505  37.315 1.00 19.65  ? 142 ALA A CA  1 ? 
ATOM   910  C C   . ALA A 1 119 ? 15.240  19.643  35.831 1.00 18.24  ? 142 ALA A C   1 ? 
ATOM   911  O O   . ALA A 1 119 ? 14.188  19.213  35.360 1.00 14.82  ? 142 ALA A O   1 ? 
ATOM   912  C CB  . ALA A 1 119 ? 16.491  18.366  37.472 1.00 19.32  ? 142 ALA A CB  1 ? 
ATOM   913  N N   . TYR A 1 120 ? 16.196  20.243  35.137 1.00 12.92  ? 143 TYR A N   1 ? 
ATOM   914  C CA  . TYR A 1 120 ? 16.135  20.262  33.665 1.00 13.79  ? 143 TYR A CA  1 ? 
ATOM   915  C C   . TYR A 1 120 ? 17.195  19.275  33.154 1.00 17.04  ? 143 TYR A C   1 ? 
ATOM   916  O O   . TYR A 1 120 ? 18.321  19.305  33.674 1.00 16.81  ? 143 TYR A O   1 ? 
ATOM   917  C CB  . TYR A 1 120 ? 16.512  21.667  33.214 1.00 11.96  ? 143 TYR A CB  1 ? 
ATOM   918  C CG  . TYR A 1 120 ? 15.468  22.759  33.368 1.00 12.79  ? 143 TYR A CG  1 ? 
ATOM   919  C CD1 . TYR A 1 120 ? 14.358  22.810  32.539 1.00 12.78  ? 143 TYR A CD1 1 ? 
ATOM   920  C CD2 . TYR A 1 120 ? 15.625  23.768  34.309 1.00 11.94  ? 143 TYR A CD2 1 ? 
ATOM   921  C CE1 . TYR A 1 120 ? 13.421  23.821  32.656 1.00 13.44  ? 143 TYR A CE1 1 ? 
ATOM   922  C CE2 . TYR A 1 120 ? 14.698  24.787  34.431 1.00 14.06  ? 143 TYR A CE2 1 ? 
ATOM   923  C CZ  . TYR A 1 120 ? 13.592  24.815  33.602 1.00 15.78  ? 143 TYR A CZ  1 ? 
ATOM   924  O OH  . TYR A 1 120 ? 12.674  25.808  33.725 1.00 13.52  ? 143 TYR A OH  1 ? 
ATOM   925  N N   . TRP A 1 121 ? 16.844  18.420  32.194 1.00 14.70  ? 144 TRP A N   1 ? 
ATOM   926  C CA  . TRP A 1 121 ? 17.844  17.538  31.550 1.00 13.63  ? 144 TRP A CA  1 ? 
ATOM   927  C C   . TRP A 1 121 ? 17.944  17.948  30.077 1.00 18.13  ? 144 TRP A C   1 ? 
ATOM   928  O O   . TRP A 1 121 ? 16.914  18.138  29.439 1.00 15.02  ? 144 TRP A O   1 ? 
ATOM   929  C CB  . TRP A 1 121 ? 17.428  16.068  31.629 1.00 14.98  ? 144 TRP A CB  1 ? 
ATOM   930  C CG  . TRP A 1 121 ? 17.643  15.411  32.966 1.00 14.73  ? 144 TRP A CG  1 ? 
ATOM   931  C CD1 . TRP A 1 121 ? 18.093  15.979  34.120 1.00 13.61  ? 144 TRP A CD1 1 ? 
ATOM   932  C CD2 . TRP A 1 121 ? 17.392  14.024  33.275 1.00 14.06  ? 144 TRP A CD2 1 ? 
ATOM   933  N NE1 . TRP A 1 121 ? 18.148  15.045  35.120 1.00 11.93  ? 144 TRP A NE1 1 ? 
ATOM   934  C CE2 . TRP A 1 121 ? 17.724  13.839  34.632 1.00 13.95  ? 144 TRP A CE2 1 ? 
ATOM   935  C CE3 . TRP A 1 121 ? 16.927  12.931  32.537 1.00 12.61  ? 144 TRP A CE3 1 ? 
ATOM   936  C CZ2 . TRP A 1 121 ? 17.597  12.604  35.262 1.00 13.14  ? 144 TRP A CZ2 1 ? 
ATOM   937  C CZ3 . TRP A 1 121 ? 16.800  11.713  33.163 1.00 13.01  ? 144 TRP A CZ3 1 ? 
ATOM   938  C CH2 . TRP A 1 121 ? 17.125  11.557  34.507 1.00 14.06  ? 144 TRP A CH2 1 ? 
ATOM   939  N N   . HIS A 1 122 ? 19.163  18.020  29.565 1.00 14.52  ? 145 HIS A N   1 ? 
ATOM   940  C CA  . HIS A 1 122 ? 19.310  18.372  28.143 1.00 16.85  ? 145 HIS A CA  1 ? 
ATOM   941  C C   . HIS A 1 122 ? 19.274  17.136  27.260 1.00 16.79  ? 145 HIS A C   1 ? 
ATOM   942  O O   . HIS A 1 122 ? 19.634  16.058  27.720 1.00 16.03  ? 145 HIS A O   1 ? 
ATOM   943  C CB  . HIS A 1 122 ? 20.656  19.028  27.833 1.00 18.09  ? 145 HIS A CB  1 ? 
ATOM   944  C CG  . HIS A 1 122 ? 20.937  20.273  28.596 1.00 18.43  ? 145 HIS A CG  1 ? 
ATOM   945  N ND1 . HIS A 1 122 ? 20.040  21.312  28.681 1.00 17.23  ? 145 HIS A ND1 1 ? 
ATOM   946  C CD2 . HIS A 1 122 ? 22.015  20.658  29.282 1.00 15.89  ? 145 HIS A CD2 1 ? 
ATOM   947  C CE1 . HIS A 1 122 ? 20.569  22.278  29.412 1.00 15.74  ? 145 HIS A CE1 1 ? 
ATOM   948  N NE2 . HIS A 1 122 ? 21.764  21.900  29.789 1.00 17.90  ? 145 HIS A NE2 1 ? 
ATOM   949  N N   . ASN A 1 123 ? 18.808  17.323  26.032 1.00 15.52  ? 146 ASN A N   1 ? 
ATOM   950  C CA  . ASN A 1 123 ? 18.949  16.255  25.017 1.00 16.15  ? 146 ASN A CA  1 ? 
ATOM   951  C C   . ASN A 1 123 ? 19.803  16.941  23.948 1.00 16.21  ? 146 ASN A C   1 ? 
ATOM   952  O O   . ASN A 1 123 ? 21.010  16.718  23.906 1.00 17.49  ? 146 ASN A O   1 ? 
ATOM   953  C CB  . ASN A 1 123 ? 17.627  15.687  24.523 1.00 16.65  ? 146 ASN A CB  1 ? 
ATOM   954  C CG  . ASN A 1 123 ? 17.792  14.617  23.468 1.00 21.07  ? 146 ASN A CG  1 ? 
ATOM   955  O OD1 . ASN A 1 123 ? 18.802  14.573  22.764 1.00 23.02  ? 146 ASN A OD1 1 ? 
ATOM   956  N ND2 . ASN A 1 123 ? 16.807  13.746  23.333 1.00 20.05  ? 146 ASN A ND2 1 ? 
ATOM   957  N N   . GLY A 1 124 ? 19.175  17.833  23.200 1.00 13.34  ? 147 GLY A N   1 ? 
ATOM   958  C CA  . GLY A 1 124 ? 19.940  18.581  22.204 1.00 14.66  ? 147 GLY A CA  1 ? 
ATOM   959  C C   . GLY A 1 124 ? 19.092  19.425  21.294 1.00 17.06  ? 147 GLY A C   1 ? 
ATOM   960  O O   . GLY A 1 124 ? 17.892  19.545  21.526 1.00 15.39  ? 147 GLY A O   1 ? 
ATOM   961  N N   . MET A 1 125 ? 19.752  19.995  20.297 1.00 15.93  ? 148 MET A N   1 ? 
ATOM   962  C CA  . MET A 1 125 ? 19.045  20.864  19.344 1.00 17.66  ? 148 MET A CA  1 ? 
ATOM   963  C C   . MET A 1 125 ? 18.257  19.987  18.374 1.00 19.68  ? 148 MET A C   1 ? 
ATOM   964  O O   . MET A 1 125 ? 18.626  18.825  18.169 1.00 14.93  ? 148 MET A O   1 ? 
ATOM   965  C CB  . MET A 1 125 ? 19.995  21.759  18.535 1.00 19.05  ? 148 MET A CB  1 ? 
ATOM   966  C CG  . MET A 1 125 ? 20.959  22.570  19.369 1.00 17.99  ? 148 MET A CG  1 ? 
ATOM   967  S SD  . MET A 1 125 ? 20.107  23.766  20.411 1.00 23.85  ? 148 MET A SD  1 ? 
ATOM   968  C CE  . MET A 1 125 ? 19.499  24.958  19.213 1.00 24.23  ? 148 MET A CE  1 ? 
ATOM   969  N N   . LYS A 1 126 ? 17.244  20.592  17.777 1.00 17.01  ? 149 LYS A N   1 ? 
ATOM   970  C CA  . LYS A 1 126 ? 16.414  19.847  16.815 1.00 17.12  ? 149 LYS A CA  1 ? 
ATOM   971  C C   . LYS A 1 126 ? 16.882  20.093  15.381 1.00 18.36  ? 149 LYS A C   1 ? 
ATOM   972  O O   . LYS A 1 126 ? 17.311  21.210  15.072 1.00 19.56  ? 149 LYS A O   1 ? 
ATOM   973  C CB  . LYS A 1 126 ? 14.934  20.221  16.914 1.00 18.59  ? 149 LYS A CB  1 ? 
ATOM   974  C CG  . LYS A 1 126 ? 14.201  19.641  18.107 1.00 18.41  ? 149 LYS A CG  1 ? 
ATOM   975  C CD  . LYS A 1 126 ? 12.722  19.995  18.141 1.00 18.74  ? 149 LYS A CD  1 ? 
ATOM   976  C CE  . LYS A 1 126 ? 12.481  21.462  18.051 1.00 20.73  ? 149 LYS A CE  1 ? 
ATOM   977  N NZ  . LYS A 1 126 ? 11.074  21.793  18.256 1.00 13.26  ? 149 LYS A NZ  1 ? 
ATOM   978  N N   . GLN A 1 127 ? 16.798  19.051  14.571 1.00 15.83  ? 150 GLN A N   1 ? 
ATOM   979  C CA  . GLN A 1 127 ? 17.094  19.157  13.133 1.00 17.17  ? 150 GLN A CA  1 ? 
ATOM   980  C C   . GLN A 1 127 ? 15.797  18.844  12.376 1.00 18.64  ? 150 GLN A C   1 ? 
ATOM   981  O O   . GLN A 1 127 ? 14.826  18.448  13.011 1.00 14.89  ? 150 GLN A O   1 ? 
ATOM   982  C CB  . GLN A 1 127 ? 18.191  18.153  12.779 1.00 15.81  ? 150 GLN A CB  1 ? 
ATOM   983  C CG  . GLN A 1 127 ? 19.295  18.033  13.821 1.00 17.89  ? 150 GLN A CG  1 ? 
ATOM   984  C CD  . GLN A 1 127 ? 19.987  19.346  14.113 1.00 17.00  ? 150 GLN A CD  1 ? 
ATOM   985  O OE1 . GLN A 1 127 ? 19.918  20.296  13.331 1.00 18.65  ? 150 GLN A OE1 1 ? 
ATOM   986  N NE2 . GLN A 1 127 ? 20.654  19.412  15.253 1.00 16.33  ? 150 GLN A NE2 1 ? 
ATOM   987  N N   . LEU A 1 128 ? 15.838  18.979  11.057 1.00 17.75  ? 151 LEU A N   1 ? 
ATOM   988  C CA  . LEU A 1 128 ? 14.662  18.682  10.211 1.00 15.40  ? 151 LEU A CA  1 ? 
ATOM   989  C C   . LEU A 1 128 ? 14.910  17.398  9.404  1.00 18.24  ? 151 LEU A C   1 ? 
ATOM   990  O O   . LEU A 1 128 ? 16.064  17.094  9.128  1.00 19.13  ? 151 LEU A O   1 ? 
ATOM   991  C CB  . LEU A 1 128 ? 14.389  19.870  9.297  1.00 18.72  ? 151 LEU A CB  1 ? 
ATOM   992  C CG  . LEU A 1 128 ? 13.857  21.133  9.975  1.00 17.00  ? 151 LEU A CG  1 ? 
ATOM   993  C CD1 . LEU A 1 128 ? 14.047  22.322  9.059  1.00 17.65  ? 151 LEU A CD1 1 ? 
ATOM   994  C CD2 . LEU A 1 128 ? 12.397  20.949  10.319 1.00 15.71  ? 151 LEU A CD2 1 ? 
ATOM   995  N N   . SER A 1 129 ? 13.834  16.685  9.094  1.00 18.06  ? 152 SER A N   1 ? 
ATOM   996  C CA  . SER A 1 129 ? 13.930  15.432  8.319  1.00 18.32  ? 152 SER A CA  1 ? 
ATOM   997  C C   . SER A 1 129 ? 12.754  15.375  7.350  1.00 17.73  ? 152 SER A C   1 ? 
ATOM   998  O O   . SER A 1 129 ? 11.697  15.892  7.698  1.00 21.58  ? 152 SER A O   1 ? 
ATOM   999  C CB  . SER A 1 129 ? 13.884  14.229  9.215  1.00 17.39  ? 152 SER A CB  1 ? 
ATOM   1000 O OG  . SER A 1 129 ? 12.617  14.061  9.815  1.00 19.50  ? 152 SER A OG  1 ? 
ATOM   1001 N N   . ALA A 1 130 ? 12.957  14.752  6.206  1.00 17.92  ? 153 ALA A N   1 ? 
ATOM   1002 C CA  . ALA A 1 130 ? 11.845  14.528  5.269  1.00 19.95  ? 153 ALA A CA  1 ? 
ATOM   1003 C C   . ALA A 1 130 ? 12.289  13.554  4.174  1.00 21.18  ? 153 ALA A C   1 ? 
ATOM   1004 O O   . ALA A 1 130 ? 13.415  13.060  4.195  1.00 18.65  ? 153 ALA A O   1 ? 
ATOM   1005 C CB  . ALA A 1 130 ? 11.367  15.826  4.693  1.00 18.88  ? 153 ALA A CB  1 ? 
ATOM   1006 N N   . ASN A 1 131 ? 11.391  13.316  3.231  1.00 24.69  ? 154 ASN A N   1 ? 
ATOM   1007 C CA  . ASN A 1 131 ? 11.704  12.372  2.120  1.00 24.78  ? 154 ASN A CA  1 ? 
ATOM   1008 C C   . ASN A 1 131 ? 12.081  13.190  0.883  1.00 26.15  ? 154 ASN A C   1 ? 
ATOM   1009 O O   . ASN A 1 131 ? 12.285  12.600  -0.183 1.00 22.43  ? 154 ASN A O   1 ? 
ATOM   1010 C CB  . ASN A 1 131 ? 10.601  11.331  1.996  1.00 27.00  ? 154 ASN A CB  1 ? 
ATOM   1011 C CG  . ASN A 1 131 ? 10.810  10.234  3.011  1.00 32.06  ? 154 ASN A CG  1 ? 
ATOM   1012 O OD1 . ASN A 1 131 ? 11.938  9.764   3.192  1.00 28.73  ? 154 ASN A OD1 1 ? 
ATOM   1013 N ND2 . ASN A 1 131 ? 9.752   9.827   3.689  1.00 26.94  ? 154 ASN A ND2 1 ? 
ATOM   1014 N N   . ARG A 1 132 ? 12.135  14.504  1.042  1.00 24.23  ? 155 ARG A N   1 ? 
ATOM   1015 C CA  . ARG A 1 132 ? 12.614  15.394  -0.029 1.00 24.81  ? 155 ARG A CA  1 ? 
ATOM   1016 C C   . ARG A 1 132 ? 13.631  16.324  0.639  1.00 30.41  ? 155 ARG A C   1 ? 
ATOM   1017 O O   . ARG A 1 132 ? 13.579  16.466  1.858  1.00 28.72  ? 155 ARG A O   1 ? 
ATOM   1018 C CB  . ARG A 1 132 ? 11.484  16.202  -0.669 1.00 25.65  ? 155 ARG A CB  1 ? 
ATOM   1019 C CG  . ARG A 1 132 ? 10.788  17.197  0.244  1.00 31.59  ? 155 ARG A CG  1 ? 
ATOM   1020 C CD  . ARG A 1 132 ? 10.522  18.491  -0.491 1.00 35.91  ? 155 ARG A CD  1 ? 
ATOM   1021 N NE  . ARG A 1 132 ? 11.799  19.106  -0.859 1.00 49.50  ? 155 ARG A NE  1 ? 
ATOM   1022 C CZ  . ARG A 1 132 ? 11.998  19.921  -1.882 1.00 51.72  ? 155 ARG A CZ  1 ? 
ATOM   1023 N NH1 . ARG A 1 132 ? 10.979  20.326  -2.616 1.00 47.67  ? 155 ARG A NH1 1 ? 
ATOM   1024 N NH2 . ARG A 1 132 ? 13.219  20.327  -2.162 1.00 39.72  ? 155 ARG A NH2 1 ? 
ATOM   1025 N N   . PRO A 1 133 ? 14.568  16.922  -0.115 1.00 30.41  ? 156 PRO A N   1 ? 
ATOM   1026 C CA  . PRO A 1 133 ? 15.515  17.855  0.469  1.00 25.31  ? 156 PRO A CA  1 ? 
ATOM   1027 C C   . PRO A 1 133 ? 14.904  19.103  1.084  1.00 25.33  ? 156 PRO A C   1 ? 
ATOM   1028 O O   . PRO A 1 133 ? 13.955  19.658  0.550  1.00 25.30  ? 156 PRO A O   1 ? 
ATOM   1029 C CB  . PRO A 1 133 ? 16.431  18.174  -0.727 1.00 29.31  ? 156 PRO A CB  1 ? 
ATOM   1030 C CG  . PRO A 1 133 ? 16.261  17.002  -1.651 1.00 29.16  ? 156 PRO A CG  1 ? 
ATOM   1031 C CD  . PRO A 1 133 ? 14.801  16.651  -1.516 1.00 27.89  ? 156 PRO A CD  1 ? 
ATOM   1032 N N   . LEU A 1 134 ? 15.460  19.527  2.214  1.00 30.42  ? 157 LEU A N   1 ? 
ATOM   1033 C CA  . LEU A 1 134 ? 15.011  20.777  2.872  1.00 28.74  ? 157 LEU A CA  1 ? 
ATOM   1034 C C   . LEU A 1 134 ? 16.196  21.757  2.955  1.00 29.46  ? 157 LEU A C   1 ? 
ATOM   1035 O O   . LEU A 1 134 ? 16.914  21.737  3.947  1.00 29.54  ? 157 LEU A O   1 ? 
ATOM   1036 C CB  . LEU A 1 134 ? 14.462  20.398  4.242  1.00 27.23  ? 157 LEU A CB  1 ? 
ATOM   1037 C CG  . LEU A 1 134 ? 13.189  19.550  4.263  1.00 19.86  ? 157 LEU A CG  1 ? 
ATOM   1038 C CD1 . LEU A 1 134 ? 12.809  19.279  5.703  1.00 17.96  ? 157 LEU A CD1 1 ? 
ATOM   1039 C CD2 . LEU A 1 134 ? 12.064  20.264  3.549  1.00 19.10  ? 157 LEU A CD2 1 ? 
ATOM   1040 N N   . LEU A 1 135 ? 16.385  22.582  1.924  1.00 27.31  ? 158 LEU A N   1 ? 
ATOM   1041 C CA  . LEU A 1 135 ? 17.551  23.496  1.895  1.00 29.42  ? 158 LEU A CA  1 ? 
ATOM   1042 C C   . LEU A 1 135 ? 17.058  24.933  2.082  1.00 26.43  ? 158 LEU A C   1 ? 
ATOM   1043 O O   . LEU A 1 135 ? 17.721  25.706  2.772  1.00 33.50  ? 158 LEU A O   1 ? 
ATOM   1044 C CB  . LEU A 1 135 ? 18.314  23.338  0.585  1.00 29.41  ? 158 LEU A CB  1 ? 
ATOM   1045 C CG  . LEU A 1 135 ? 18.433  21.923  0.014  1.00 38.89  ? 158 LEU A CG  1 ? 
ATOM   1046 C CD1 . LEU A 1 135 ? 19.077  22.008  -1.353 1.00 37.24  ? 158 LEU A CD1 1 ? 
ATOM   1047 C CD2 . LEU A 1 135 ? 19.254  21.031  0.918  1.00 32.81  ? 158 LEU A CD2 1 ? 
ATOM   1048 N N   . GLU A 1 136 ? 15.929  25.237  1.478  1.00 28.16  ? 159 GLU A N   1 ? 
ATOM   1049 C CA  . GLU A 1 136 ? 15.331  26.584  1.593  1.00 24.80  ? 159 GLU A CA  1 ? 
ATOM   1050 C C   . GLU A 1 136 ? 13.941  26.455  2.231  1.00 25.43  ? 159 GLU A C   1 ? 
ATOM   1051 O O   . GLU A 1 136 ? 13.272  25.445  2.027  1.00 25.47  ? 159 GLU A O   1 ? 
ATOM   1052 C CB  . GLU A 1 136 ? 15.323  27.145  0.176  1.00 28.87  ? 159 GLU A CB  1 ? 
ATOM   1053 C CG  . GLU A 1 136 ? 16.715  27.312  -0.426 1.00 25.25  ? 159 GLU A CG  1 ? 
ATOM   1054 C CD  . GLU A 1 136 ? 17.678  28.217  0.319  1.00 30.98  ? 159 GLU A CD  1 ? 
ATOM   1055 O OE1 . GLU A 1 136 ? 18.892  28.024  0.132  1.00 32.85  ? 159 GLU A OE1 1 ? 
ATOM   1056 O OE2 . GLU A 1 136 ? 17.238  29.110  1.068  1.00 35.61  ? 159 GLU A OE2 1 ? 
ATOM   1057 N N   . PRO A 1 137 ? 13.499  27.445  3.014  1.00 23.90  ? 160 PRO A N   1 ? 
ATOM   1058 C CA  . PRO A 1 137 ? 12.199  27.366  3.667  1.00 27.72  ? 160 PRO A CA  1 ? 
ATOM   1059 C C   . PRO A 1 137 ? 11.004  26.973  2.767  1.00 33.63  ? 160 PRO A C   1 ? 
ATOM   1060 O O   . PRO A 1 137 ? 10.134  26.233  3.212  1.00 27.97  ? 160 PRO A O   1 ? 
ATOM   1061 C CB  . PRO A 1 137 ? 12.070  28.770  4.297  1.00 26.67  ? 160 PRO A CB  1 ? 
ATOM   1062 C CG  . PRO A 1 137 ? 13.147  29.604  3.661  1.00 23.22  ? 160 PRO A CG  1 ? 
ATOM   1063 C CD  . PRO A 1 137 ? 14.251  28.637  3.321  1.00 27.19  ? 160 PRO A CD  1 ? 
ATOM   1064 N N   . GLU A 1 138 ? 10.989  27.436  1.511  1.00 32.78  ? 161 GLU A N   1 ? 
ATOM   1065 C CA  . GLU A 1 138 ? 9.901   27.093  0.560  1.00 29.54  ? 161 GLU A CA  1 ? 
ATOM   1066 C C   . GLU A 1 138 ? 9.842   25.569  0.356  1.00 24.98  ? 161 GLU A C   1 ? 
ATOM   1067 O O   . GLU A 1 138 ? 8.785   25.067  -0.022 1.00 24.63  ? 161 GLU A O   1 ? 
ATOM   1068 C CB  . GLU A 1 138 ? 10.137  27.757  -0.791 1.00 29.85  ? 161 GLU A CB  1 ? 
ATOM   1069 C CG  . GLU A 1 138 ? 11.591  27.688  -1.238 1.00 41.05  ? 161 GLU A CG  1 ? 
ATOM   1070 C CD  . GLU A 1 138 ? 12.285  29.026  -1.087 1.00 71.31  ? 161 GLU A CD  1 ? 
ATOM   1071 O OE1 . GLU A 1 138 ? 12.315  29.568  0.043  1.00 69.17  ? 161 GLU A OE1 1 ? 
ATOM   1072 O OE2 . GLU A 1 138 ? 12.780  29.528  -2.116 1.00 62.39  ? 161 GLU A OE2 1 ? 
ATOM   1073 N N   . ASP A 1 139 ? 10.942  24.882  0.622  1.00 20.25  ? 162 ASP A N   1 ? 
ATOM   1074 C CA  . ASP A 1 139 ? 11.008  23.410  0.447  1.00 22.46  ? 162 ASP A CA  1 ? 
ATOM   1075 C C   . ASP A 1 139 ? 10.017  22.688  1.381  1.00 26.50  ? 162 ASP A C   1 ? 
ATOM   1076 O O   . ASP A 1 139 ? 9.664   21.537  1.087  1.00 25.37  ? 162 ASP A O   1 ? 
ATOM   1077 C CB  . ASP A 1 139 ? 12.444  22.930  0.593  1.00 24.22  ? 162 ASP A CB  1 ? 
ATOM   1078 C CG  . ASP A 1 139 ? 13.440  23.466  -0.427 1.00 28.84  ? 162 ASP A CG  1 ? 
ATOM   1079 O OD1 . ASP A 1 139 ? 13.008  24.164  -1.360 1.00 34.59  ? 162 ASP A OD1 1 ? 
ATOM   1080 O OD2 . ASP A 1 139 ? 14.641  23.182  -0.282 1.00 33.43  ? 162 ASP A OD2 1 ? 
ATOM   1081 N N   . ALA A 1 140 ? 9.562   23.345  2.444  1.00 21.78  ? 163 ALA A N   1 ? 
ATOM   1082 C CA  . ALA A 1 140 ? 8.698   22.660  3.435  1.00 26.02  ? 163 ALA A CA  1 ? 
ATOM   1083 C C   . ALA A 1 140 ? 7.221   22.750  3.055  1.00 27.43  ? 163 ALA A C   1 ? 
ATOM   1084 O O   . ALA A 1 140 ? 6.419   21.996  3.595  1.00 23.70  ? 163 ALA A O   1 ? 
ATOM   1085 C CB  . ALA A 1 140 ? 8.943   23.239  4.799  1.00 22.68  ? 163 ALA A CB  1 ? 
ATOM   1086 N N   . ARG A 1 141 ? 6.892   23.635  2.116  1.00 26.37  ? 164 ARG A N   1 ? 
ATOM   1087 C CA  . ARG A 1 141 ? 5.472   23.841  1.749  1.00 22.14  ? 164 ARG A CA  1 ? 
ATOM   1088 C C   . ARG A 1 141 ? 4.815   22.510  1.371  1.00 21.62  ? 164 ARG A C   1 ? 
ATOM   1089 O O   . ARG A 1 141 ? 5.428   21.734  0.645  1.00 24.70  ? 164 ARG A O   1 ? 
ATOM   1090 C CB  . ARG A 1 141 ? 5.302   24.818  0.578  1.00 28.54  ? 164 ARG A CB  1 ? 
ATOM   1091 C CG  . ARG A 1 141 ? 5.686   26.264  0.844  1.00 37.71  ? 164 ARG A CG  1 ? 
ATOM   1092 C CD  . ARG A 1 141 ? 5.665   27.055  -0.454 1.00 37.71  ? 164 ARG A CD  1 ? 
ATOM   1093 N NE  . ARG A 1 141 ? 4.327   27.103  -1.051 1.00 35.60  ? 164 ARG A NE  1 ? 
ATOM   1094 C CZ  . ARG A 1 141 ? 3.428   28.044  -0.804 1.00 33.27  ? 164 ARG A CZ  1 ? 
ATOM   1095 N NH1 . ARG A 1 141 ? 3.756   29.105  -0.092 1.00 28.46  ? 164 ARG A NH1 1 ? 
ATOM   1096 N NH2 . ARG A 1 141 ? 2.200   27.919  -1.266 1.00 27.71  ? 164 ARG A NH2 1 ? 
ATOM   1097 N N   . GLY A 1 142 ? 3.605   22.274  1.860  1.00 23.10  ? 165 GLY A N   1 ? 
ATOM   1098 C CA  . GLY A 1 142 ? 2.851   21.079  1.456  1.00 21.39  ? 165 GLY A CA  1 ? 
ATOM   1099 C C   . GLY A 1 142 ? 3.230   19.839  2.230  1.00 26.62  ? 165 GLY A C   1 ? 
ATOM   1100 O O   . GLY A 1 142 ? 2.468   18.872  2.188  1.00 27.85  ? 165 GLY A O   1 ? 
ATOM   1101 N N   . LEU A 1 143 ? 4.371   19.856  2.897  1.00 23.79  ? 166 LEU A N   1 ? 
ATOM   1102 C CA  . LEU A 1 143 ? 4.783   18.611  3.584  1.00 26.85  ? 166 LEU A CA  1 ? 
ATOM   1103 C C   . LEU A 1 143 ? 3.931   18.397  4.843  1.00 25.30  ? 166 LEU A C   1 ? 
ATOM   1104 O O   . LEU A 1 143 ? 3.378   19.372  5.362  1.00 27.33  ? 166 LEU A O   1 ? 
ATOM   1105 C CB  . LEU A 1 143 ? 6.273   18.588  3.905  1.00 23.21  ? 166 LEU A CB  1 ? 
ATOM   1106 C CG  . LEU A 1 143 ? 7.223   18.606  2.706  1.00 28.91  ? 166 LEU A CG  1 ? 
ATOM   1107 C CD1 . LEU A 1 143 ? 8.664   18.497  3.158  1.00 24.31  ? 166 LEU A CD1 1 ? 
ATOM   1108 C CD2 . LEU A 1 143 ? 6.874   17.486  1.751  1.00 25.10  ? 166 LEU A CD2 1 ? 
ATOM   1109 N N   . LYS A 1 144 ? 3.871   17.154  5.296  1.00 20.62  ? 167 LYS A N   1 ? 
ATOM   1110 C CA  . LYS A 1 144 ? 3.152   16.813  6.538  1.00 24.70  ? 167 LYS A CA  1 ? 
ATOM   1111 C C   . LYS A 1 144 ? 4.207   16.465  7.597  1.00 22.71  ? 167 LYS A C   1 ? 
ATOM   1112 O O   . LYS A 1 144 ? 4.895   15.459  7.436  1.00 21.40  ? 167 LYS A O   1 ? 
ATOM   1113 C CB  . LYS A 1 144 ? 2.217   15.632  6.286  1.00 26.64  ? 167 LYS A CB  1 ? 
ATOM   1114 C CG  . LYS A 1 144 ? 1.334   15.711  5.061  1.00 33.14  ? 167 LYS A CG  1 ? 
ATOM   1115 C CD  . LYS A 1 144 ? 0.813   14.330  4.689  1.00 34.87  ? 167 LYS A CD  1 ? 
ATOM   1116 C CE  . LYS A 1 144 ? -0.651  14.348  4.417  1.00 46.33  ? 167 LYS A CE  1 ? 
ATOM   1117 N NZ  . LYS A 1 144 ? -1.424  13.746  5.507  1.00 67.04  ? 167 LYS A NZ  1 ? 
ATOM   1118 N N   . PHE A 1 145 ? 4.320   17.299  8.622  1.00 19.72  ? 168 PHE A N   1 ? 
ATOM   1119 C CA  . PHE A 1 145 ? 5.371   17.085  9.645  1.00 20.10  ? 168 PHE A CA  1 ? 
ATOM   1120 C C   . PHE A 1 145 ? 4.785   16.590  10.953 1.00 20.27  ? 168 PHE A C   1 ? 
ATOM   1121 O O   . PHE A 1 145 ? 3.809   17.166  11.430 1.00 21.24  ? 168 PHE A O   1 ? 
ATOM   1122 C CB  . PHE A 1 145 ? 6.171   18.338  9.989  1.00 19.16  ? 168 PHE A CB  1 ? 
ATOM   1123 C CG  . PHE A 1 145 ? 7.096   18.856  8.902  1.00 18.59  ? 168 PHE A CG  1 ? 
ATOM   1124 C CD1 . PHE A 1 145 ? 6.621   19.708  7.914  1.00 20.98  ? 168 PHE A CD1 1 ? 
ATOM   1125 C CD2 . PHE A 1 145 ? 8.437   18.501  8.879  1.00 17.91  ? 168 PHE A CD2 1 ? 
ATOM   1126 C CE1 . PHE A 1 145 ? 7.467   20.186  6.932  1.00 23.30  ? 168 PHE A CE1 1 ? 
ATOM   1127 C CE2 . PHE A 1 145 ? 9.277   18.984  7.893  1.00 25.30  ? 168 PHE A CE2 1 ? 
ATOM   1128 C CZ  . PHE A 1 145 ? 8.791   19.826  6.925  1.00 24.14  ? 168 PHE A CZ  1 ? 
ATOM   1129 N N   . ARG A 1 146 ? 5.369   15.517  11.477 1.00 16.91  ? 169 ARG A N   1 ? 
ATOM   1130 C CA  . ARG A 1 146 ? 4.988   15.059  12.820 1.00 15.95  ? 169 ARG A CA  1 ? 
ATOM   1131 C C   . ARG A 1 146 ? 5.598   16.049  13.805 1.00 16.45  ? 169 ARG A C   1 ? 
ATOM   1132 O O   . ARG A 1 146 ? 6.784   16.376  13.649 1.00 17.18  ? 169 ARG A O   1 ? 
ATOM   1133 C CB  . ARG A 1 146 ? 5.516   13.685  13.226 1.00 16.32  ? 169 ARG A CB  1 ? 
ATOM   1134 C CG  . ARG A 1 146 ? 5.162   13.239  14.637 1.00 14.19  ? 169 ARG A CG  1 ? 
ATOM   1135 C CD  . ARG A 1 146 ? 6.315   13.487  15.585 1.00 15.95  ? 169 ARG A CD  1 ? 
ATOM   1136 N NE  . ARG A 1 146 ? 5.958   13.340  16.997 1.00 17.46  ? 169 ARG A NE  1 ? 
ATOM   1137 C CZ  . ARG A 1 146 ? 6.820   13.514  17.985 1.00 19.92  ? 169 ARG A CZ  1 ? 
ATOM   1138 N NH1 . ARG A 1 146 ? 8.063   13.859  17.718 1.00 16.87  ? 169 ARG A NH1 1 ? 
ATOM   1139 N NH2 . ARG A 1 146 ? 6.433   13.356  19.233 1.00 18.36  ? 169 ARG A NH2 1 ? 
ATOM   1140 N N   . VAL A 1 147 ? 4.789   16.498  14.746 1.00 16.53  ? 170 VAL A N   1 ? 
ATOM   1141 C CA  . VAL A 1 147 ? 5.316   17.343  15.836 1.00 14.93  ? 170 VAL A CA  1 ? 
ATOM   1142 C C   . VAL A 1 147 ? 4.892   16.741  17.180 1.00 15.57  ? 170 VAL A C   1 ? 
ATOM   1143 O O   . VAL A 1 147 ? 3.961   15.929  17.224 1.00 18.59  ? 170 VAL A O   1 ? 
ATOM   1144 C CB  . VAL A 1 147 ? 4.834   18.803  15.750 1.00 16.01  ? 170 VAL A CB  1 ? 
ATOM   1145 C CG1 . VAL A 1 147 ? 5.631   19.600  14.732 1.00 14.75  ? 170 VAL A CG1 1 ? 
ATOM   1146 C CG2 . VAL A 1 147 ? 3.340   18.899  15.475 1.00 16.41  ? 170 VAL A CG2 1 ? 
ATOM   1147 N N   . GLN A 1 148 ? 5.592   17.142  18.226 1.00 16.67  ? 171 GLN A N   1 ? 
ATOM   1148 C CA  . GLN A 1 148 ? 5.129   16.786  19.574 1.00 15.23  ? 171 GLN A CA  1 ? 
ATOM   1149 C C   . GLN A 1 148 ? 3.793   17.514  19.797 1.00 18.22  ? 171 GLN A C   1 ? 
ATOM   1150 O O   . GLN A 1 148 ? 3.507   18.472  19.065 1.00 17.21  ? 171 GLN A O   1 ? 
ATOM   1151 C CB  . GLN A 1 148 ? 6.169   17.278  20.576 1.00 14.46  ? 171 GLN A CB  1 ? 
ATOM   1152 C CG  . GLN A 1 148 ? 7.557   16.687  20.388 1.00 14.93  ? 171 GLN A CG  1 ? 
ATOM   1153 C CD  . GLN A 1 148 ? 8.610   17.477  21.125 1.00 17.56  ? 171 GLN A CD  1 ? 
ATOM   1154 O OE1 . GLN A 1 148 ? 8.865   17.249  22.309 1.00 18.65  ? 171 GLN A OE1 1 ? 
ATOM   1155 N NE2 . GLN A 1 148 ? 9.213   18.432  20.436 1.00 16.65  ? 171 GLN A NE2 1 ? 
ATOM   1156 N N   . ALA A 1 149 ? 3.022   17.080  20.792 1.00 20.70  ? 172 ALA A N   1 ? 
ATOM   1157 C CA  . ALA A 1 149 ? 1.728   17.726  21.124 1.00 18.02  ? 172 ALA A CA  1 ? 
ATOM   1158 C C   . ALA A 1 149 ? 1.979   19.144  21.642 1.00 18.57  ? 172 ALA A C   1 ? 
ATOM   1159 O O   . ALA A 1 149 ? 1.888   19.350  22.849 1.00 18.37  ? 172 ALA A O   1 ? 
ATOM   1160 C CB  . ALA A 1 149 ? 0.961   16.872  22.109 1.00 14.95  ? 172 ALA A CB  1 ? 
ATOM   1161 N N   . SER A 1 150 ? 2.318   20.065  20.741 1.00 17.83  ? 173 SER A N   1 ? 
ATOM   1162 C CA  . SER A 1 150 ? 2.610   21.472  21.094 1.00 14.63  ? 173 SER A CA  1 ? 
ATOM   1163 C C   . SER A 1 150 ? 1.949   22.432  20.096 1.00 15.26  ? 173 SER A C   1 ? 
ATOM   1164 O O   . SER A 1 150 ? 2.179   22.290  18.899 1.00 20.57  ? 173 SER A O   1 ? 
ATOM   1165 C CB  . SER A 1 150 ? 4.087   21.762  21.166 1.00 13.85  ? 173 SER A CB  1 ? 
ATOM   1166 O OG  . SER A 1 150 ? 4.343   23.148  21.008 1.00 16.32  ? 173 SER A OG  1 ? 
ATOM   1167 N N   . ASP A 1 151 ? 1.215   23.410  20.612 1.00 18.36  ? 174 ASP A N   1 ? 
ATOM   1168 C CA  . ASP A 1 151 ? 0.577   24.425  19.733 1.00 21.40  ? 174 ASP A CA  1 ? 
ATOM   1169 C C   . ASP A 1 151 ? 1.662   25.257  19.045 1.00 16.49  ? 174 ASP A C   1 ? 
ATOM   1170 O O   . ASP A 1 151 ? 1.467   25.628  17.896 1.00 19.89  ? 174 ASP A O   1 ? 
ATOM   1171 C CB  . ASP A 1 151 ? -0.403  25.311  20.480 1.00 24.14  ? 174 ASP A CB  1 ? 
ATOM   1172 C CG  . ASP A 1 151 ? -1.692  24.657  20.954 1.00 33.87  ? 174 ASP A CG  1 ? 
ATOM   1173 O OD1 . ASP A 1 151 ? -2.108  23.657  20.342 1.00 30.49  ? 174 ASP A OD1 1 ? 
ATOM   1174 O OD2 . ASP A 1 151 ? -2.270  25.169  21.930 1.00 39.33  ? 174 ASP A OD2 1 ? 
ATOM   1175 N N   . VAL A 1 152 ? 2.763   25.507  19.748 1.00 17.77  ? 175 VAL A N   1 ? 
ATOM   1176 C CA  . VAL A 1 152 ? 3.876   26.317  19.171 1.00 17.82  ? 175 VAL A CA  1 ? 
ATOM   1177 C C   . VAL A 1 152 ? 4.408   25.555  17.952 1.00 17.58  ? 175 VAL A C   1 ? 
ATOM   1178 O O   . VAL A 1 152 ? 4.469   26.131  16.875 1.00 21.78  ? 175 VAL A O   1 ? 
ATOM   1179 C CB  . VAL A 1 152 ? 5.017   26.626  20.159 1.00 19.32  ? 175 VAL A CB  1 ? 
ATOM   1180 C CG1 . VAL A 1 152 ? 6.191   27.326  19.488 1.00 15.76  ? 175 VAL A CG1 1 ? 
ATOM   1181 C CG2 . VAL A 1 152 ? 4.529   27.414  21.365 1.00 18.28  ? 175 VAL A CG2 1 ? 
ATOM   1182 N N   . LEU A 1 153 ? 4.739   24.291  18.152 1.00 17.94  ? 176 LEU A N   1 ? 
ATOM   1183 C CA  . LEU A 1 153 ? 5.342   23.486  17.059 1.00 18.77  ? 176 LEU A CA  1 ? 
ATOM   1184 C C   . LEU A 1 153 ? 4.330   23.285  15.924 1.00 20.09  ? 176 LEU A C   1 ? 
ATOM   1185 O O   . LEU A 1 153 ? 4.749   23.283  14.770 1.00 20.50  ? 176 LEU A O   1 ? 
ATOM   1186 C CB  . LEU A 1 153 ? 5.846   22.192  17.689 1.00 17.94  ? 176 LEU A CB  1 ? 
ATOM   1187 C CG  . LEU A 1 153 ? 6.885   22.368  18.799 1.00 15.36  ? 176 LEU A CG  1 ? 
ATOM   1188 C CD1 . LEU A 1 153 ? 7.431   21.043  19.279 1.00 13.18  ? 176 LEU A CD1 1 ? 
ATOM   1189 C CD2 . LEU A 1 153 ? 8.008   23.282  18.375 1.00 13.78  ? 176 LEU A CD2 1 ? 
ATOM   1190 N N   . ASN A 1 154 ? 3.045   23.147  16.260 1.00 21.56  ? 177 ASN A N   1 ? 
ATOM   1191 C CA  . ASN A 1 154 ? 1.987   23.055  15.222 1.00 18.73  ? 177 ASN A CA  1 ? 
ATOM   1192 C C   . ASN A 1 154 ? 2.053   24.317  14.360 1.00 21.74  ? 177 ASN A C   1 ? 
ATOM   1193 O O   . ASN A 1 154 ? 2.119   24.177  13.141 1.00 24.16  ? 177 ASN A O   1 ? 
ATOM   1194 C CB  . ASN A 1 154 ? 0.609   22.877  15.838 1.00 20.35  ? 177 ASN A CB  1 ? 
ATOM   1195 C CG  . ASN A 1 154 ? -0.395  22.310  14.870 1.00 24.52  ? 177 ASN A CG  1 ? 
ATOM   1196 O OD1 . ASN A 1 154 ? -0.591  21.093  14.826 1.00 41.87  ? 177 ASN A OD1 1 ? 
ATOM   1197 N ND2 . ASN A 1 154 ? -1.040  23.170  14.101 1.00 29.43  ? 177 ASN A ND2 1 ? 
ATOM   1198 N N   . GLU A 1 155 ? 2.081   25.480  14.999 1.00 21.79  ? 178 GLU A N   1 ? 
ATOM   1199 C CA  . GLU A 1 155 ? 2.118   26.782  14.293 1.00 25.52  ? 178 GLU A CA  1 ? 
ATOM   1200 C C   . GLU A 1 155 ? 3.443   26.979  13.534 1.00 24.09  ? 178 GLU A C   1 ? 
ATOM   1201 O O   . GLU A 1 155 ? 3.415   27.568  12.444 1.00 22.78  ? 178 GLU A O   1 ? 
ATOM   1202 C CB  . GLU A 1 155 ? 1.856   27.839  15.356 1.00 30.79  ? 178 GLU A CB  1 ? 
ATOM   1203 C CG  . GLU A 1 155 ? 1.522   29.214  14.794 1.00 41.21  ? 178 GLU A CG  1 ? 
ATOM   1204 C CD  . GLU A 1 155 ? 0.484   29.138  13.692 1.00 52.09  ? 178 GLU A CD  1 ? 
ATOM   1205 O OE1 . GLU A 1 155 ? 0.730   29.760  12.638 1.00 50.49  ? 178 GLU A OE1 1 ? 
ATOM   1206 O OE2 . GLU A 1 155 ? -0.551  28.467  13.888 1.00 35.80  ? 178 GLU A OE2 1 ? 
ATOM   1207 N N   . GLN A 1 156 ? 4.550   26.506  14.086 1.00 21.00  ? 179 GLN A N   1 ? 
ATOM   1208 C CA  . GLN A 1 156 ? 5.872   26.609  13.420 1.00 23.30  ? 179 GLN A CA  1 ? 
ATOM   1209 C C   . GLN A 1 156 ? 5.768   26.129  11.962 1.00 21.09  ? 179 GLN A C   1 ? 
ATOM   1210 O O   . GLN A 1 156 ? 6.230   26.844  11.066 1.00 20.76  ? 179 GLN A O   1 ? 
ATOM   1211 C CB  . GLN A 1 156 ? 6.859   25.767  14.231 1.00 26.51  ? 179 GLN A CB  1 ? 
ATOM   1212 C CG  . GLN A 1 156 ? 8.151   25.374  13.538 1.00 24.36  ? 179 GLN A CG  1 ? 
ATOM   1213 C CD  . GLN A 1 156 ? 9.132   24.782  14.523 1.00 26.75  ? 179 GLN A CD  1 ? 
ATOM   1214 O OE1 . GLN A 1 156 ? 9.620   25.465  15.427 1.00 24.26  ? 179 GLN A OE1 1 ? 
ATOM   1215 N NE2 . GLN A 1 156 ? 9.406   23.497  14.375 1.00 22.22  ? 179 GLN A NE2 1 ? 
ATOM   1216 N N   . PHE A 1 157 ? 5.164   24.965  11.749 1.00 18.91  ? 180 PHE A N   1 ? 
ATOM   1217 C CA  . PHE A 1 157 ? 5.130   24.402  10.371 1.00 18.23  ? 180 PHE A CA  1 ? 
ATOM   1218 C C   . PHE A 1 157 ? 3.967   25.044  9.594  1.00 21.95  ? 180 PHE A C   1 ? 
ATOM   1219 O O   . PHE A 1 157 ? 4.059   25.180  8.376  1.00 22.06  ? 180 PHE A O   1 ? 
ATOM   1220 C CB  . PHE A 1 157 ? 5.134   22.877  10.451 1.00 17.27  ? 180 PHE A CB  1 ? 
ATOM   1221 C CG  . PHE A 1 157 ? 6.467   22.276  10.872 1.00 21.53  ? 180 PHE A CG  1 ? 
ATOM   1222 C CD1 . PHE A 1 157 ? 7.580   22.362  10.050 1.00 21.34  ? 180 PHE A CD1 1 ? 
ATOM   1223 C CD2 . PHE A 1 157 ? 6.607   21.637  12.096 1.00 22.49  ? 180 PHE A CD2 1 ? 
ATOM   1224 C CE1 . PHE A 1 157 ? 8.791   21.819  10.438 1.00 22.92  ? 180 PHE A CE1 1 ? 
ATOM   1225 C CE2 . PHE A 1 157 ? 7.822   21.095  12.476 1.00 20.97  ? 180 PHE A CE2 1 ? 
ATOM   1226 C CZ  . PHE A 1 157 ? 8.909   21.185  11.648 1.00 23.25  ? 180 PHE A CZ  1 ? 
ATOM   1227 N N   . ARG A 1 158 ? 2.927   25.469  10.306 1.00 19.57  ? 181 ARG A N   1 ? 
ATOM   1228 C CA  . ARG A 1 158 ? 1.812   26.177  9.631  1.00 24.92  ? 181 ARG A CA  1 ? 
ATOM   1229 C C   . ARG A 1 158 ? 2.384   27.455  8.995  1.00 25.74  ? 181 ARG A C   1 ? 
ATOM   1230 O O   . ARG A 1 158 ? 2.009   27.772  7.876  1.00 24.51  ? 181 ARG A O   1 ? 
ATOM   1231 C CB  . ARG A 1 158 ? 0.644   26.437  10.587 1.00 22.28  ? 181 ARG A CB  1 ? 
ATOM   1232 C CG  . ARG A 1 158 ? -0.067  25.196  11.107 1.00 39.71  ? 181 ARG A CG  1 ? 
ATOM   1233 C CD  . ARG A 1 158 ? -0.805  24.437  10.022 1.00 54.69  ? 181 ARG A CD  1 ? 
ATOM   1234 N NE  . ARG A 1 158 ? -1.854  25.255  9.403  1.00 74.89  ? 181 ARG A NE  1 ? 
ATOM   1235 C CZ  . ARG A 1 158 ? -2.930  25.714  10.029 1.00 66.95  ? 181 ARG A CZ  1 ? 
ATOM   1236 N NH1 . ARG A 1 158 ? -3.118  27.014  10.162 1.00 53.02  ? 181 ARG A NH1 1 ? 
ATOM   1237 N NH2 . ARG A 1 158 ? -3.819  24.869  10.515 1.00 81.23  ? 181 ARG A NH2 1 ? 
ATOM   1238 N N   . GLN A 1 159 ? 3.286   28.128  9.703  1.00 23.59  ? 182 GLN A N   1 ? 
ATOM   1239 C CA  . GLN A 1 159 ? 3.894   29.376  9.186  1.00 23.41  ? 182 GLN A CA  1 ? 
ATOM   1240 C C   . GLN A 1 159 ? 4.676   29.071  7.898  1.00 27.96  ? 182 GLN A C   1 ? 
ATOM   1241 O O   . GLN A 1 159 ? 4.749   29.951  7.044  1.00 29.45  ? 182 GLN A O   1 ? 
ATOM   1242 C CB  . GLN A 1 159 ? 4.801   29.975  10.255 1.00 27.16  ? 182 GLN A CB  1 ? 
ATOM   1243 C CG  . GLN A 1 159 ? 5.639   31.162  9.809  1.00 24.85  ? 182 GLN A CG  1 ? 
ATOM   1244 C CD  . GLN A 1 159 ? 4.834   32.431  9.666  1.00 33.80  ? 182 GLN A CD  1 ? 
ATOM   1245 O OE1 . GLN A 1 159 ? 3.779   32.598  10.284 1.00 32.88  ? 182 GLN A OE1 1 ? 
ATOM   1246 N NE2 . GLN A 1 159 ? 5.329   33.336  8.837  1.00 34.41  ? 182 GLN A NE2 1 ? 
ATOM   1247 N N   . LEU A 1 160 ? 5.232   27.866  7.791  1.00 26.13  ? 183 LEU A N   1 ? 
ATOM   1248 C CA  . LEU A 1 160 ? 5.998   27.469  6.583  1.00 23.97  ? 183 LEU A CA  1 ? 
ATOM   1249 C C   . LEU A 1 160 ? 5.056   26.914  5.502  1.00 24.73  ? 183 LEU A C   1 ? 
ATOM   1250 O O   . LEU A 1 160 ? 5.564   26.344  4.536  1.00 26.51  ? 183 LEU A O   1 ? 
ATOM   1251 C CB  . LEU A 1 160 ? 7.061   26.445  6.957  1.00 22.82  ? 183 LEU A CB  1 ? 
ATOM   1252 C CG  . LEU A 1 160 ? 8.270   26.957  7.742  1.00 22.18  ? 183 LEU A CG  1 ? 
ATOM   1253 C CD1 . LEU A 1 160 ? 9.052   25.760  8.238  1.00 18.29  ? 183 LEU A CD1 1 ? 
ATOM   1254 C CD2 . LEU A 1 160 ? 9.146   27.832  6.867  1.00 22.01  ? 183 LEU A CD2 1 ? 
ATOM   1255 N N   . ARG A 1 161 ? 3.749   27.057  5.685  1.00 26.68  ? 184 ARG A N   1 ? 
ATOM   1256 C CA  . ARG A 1 161 ? 2.739   26.578  4.703  1.00 26.38  ? 184 ARG A CA  1 ? 
ATOM   1257 C C   . ARG A 1 161 ? 2.824   25.052  4.613  1.00 23.88  ? 184 ARG A C   1 ? 
ATOM   1258 O O   . ARG A 1 161 ? 2.544   24.494  3.557  1.00 23.49  ? 184 ARG A O   1 ? 
ATOM   1259 C CB  . ARG A 1 161 ? 2.827   27.272  3.338  1.00 30.35  ? 184 ARG A CB  1 ? 
ATOM   1260 C CG  . ARG A 1 161 ? 3.204   28.744  3.366  1.00 36.83  ? 184 ARG A CG  1 ? 
ATOM   1261 C CD  . ARG A 1 161 ? 2.111   29.595  3.965  1.00 42.61  ? 184 ARG A CD  1 ? 
ATOM   1262 N NE  . ARG A 1 161 ? 0.798   29.336  3.368  1.00 55.43  ? 184 ARG A NE  1 ? 
ATOM   1263 C CZ  . ARG A 1 161 ? -0.268  30.085  3.606  1.00 55.86  ? 184 ARG A CZ  1 ? 
ATOM   1264 N NH1 . ARG A 1 161 ? -1.418  29.802  3.026  1.00 44.06  ? 184 ARG A NH1 1 ? 
ATOM   1265 N NH2 . ARG A 1 161 ? -0.173  31.119  4.424  1.00 50.14  ? 184 ARG A NH2 1 ? 
ATOM   1266 N N   . ALA A 1 162 ? 3.200   24.428  5.720  1.00 26.93  ? 185 ALA A N   1 ? 
ATOM   1267 C CA  . ALA A 1 162 ? 3.183   22.955  5.765  1.00 22.59  ? 185 ALA A CA  1 ? 
ATOM   1268 C C   . ALA A 1 162 ? 2.050   22.479  6.675  1.00 21.87  ? 185 ALA A C   1 ? 
ATOM   1269 O O   . ALA A 1 162 ? 1.395   23.307  7.314  1.00 24.99  ? 185 ALA A O   1 ? 
ATOM   1270 C CB  . ALA A 1 162 ? 4.507   22.434  6.220  1.00 24.24  ? 185 ALA A CB  1 ? 
ATOM   1271 N N   . ILE A 1 163 ? 1.818   21.175  6.682  1.00 20.76  ? 186 ILE A N   1 ? 
ATOM   1272 C CA  . ILE A 1 163 ? 0.781   20.560  7.554  1.00 22.48  ? 186 ILE A CA  1 ? 
ATOM   1273 C C   . ILE A 1 163 ? 1.466   19.965  8.796  1.00 22.55  ? 186 ILE A C   1 ? 
ATOM   1274 O O   . ILE A 1 163 ? 2.463   19.280  8.636  1.00 24.61  ? 186 ILE A O   1 ? 
ATOM   1275 C CB  . ILE A 1 163 ? 0.018   19.477  6.774  1.00 24.33  ? 186 ILE A CB  1 ? 
ATOM   1276 C CG1 . ILE A 1 163 ? -0.780  20.070  5.620  1.00 25.44  ? 186 ILE A CG1 1 ? 
ATOM   1277 C CG2 . ILE A 1 163 ? -0.855  18.631  7.701  1.00 23.26  ? 186 ILE A CG2 1 ? 
ATOM   1278 C CD1 . ILE A 1 163 ? -0.926  19.136  4.435  1.00 28.08  ? 186 ILE A CD1 1 ? 
ATOM   1279 N N   . SER A 1 164 ? 0.940   20.256  9.976  1.00 21.83  ? 187 SER A N   1 ? 
ATOM   1280 C CA  . SER A 1 164 ? 1.478   19.691  11.231 1.00 22.19  ? 187 SER A CA  1 ? 
ATOM   1281 C C   . SER A 1 164 ? 0.584   18.555  11.739 1.00 18.46  ? 187 SER A C   1 ? 
ATOM   1282 O O   . SER A 1 164 ? -0.633  18.704  11.696 1.00 18.41  ? 187 SER A O   1 ? 
ATOM   1283 C CB  . SER A 1 164 ? 1.593   20.761  12.285 1.00 25.31  ? 187 SER A CB  1 ? 
ATOM   1284 O OG  . SER A 1 164 ? 2.512   21.776  11.920 1.00 31.49  ? 187 SER A OG  1 ? 
ATOM   1285 N N   . ARG A 1 165 ? 1.189   17.478  12.231 1.00 16.24  ? 188 ARG A N   1 ? 
ATOM   1286 C CA  . ARG A 1 165 ? 0.390   16.398  12.857 1.00 18.08  ? 188 ARG A CA  1 ? 
ATOM   1287 C C   . ARG A 1 165 ? 0.976   16.093  14.246 1.00 16.75  ? 188 ARG A C   1 ? 
ATOM   1288 O O   . ARG A 1 165 ? 2.080   15.564  14.329 1.00 16.07  ? 188 ARG A O   1 ? 
ATOM   1289 C CB  . ARG A 1 165 ? 0.300   15.145  11.982 1.00 21.12  ? 188 ARG A CB  1 ? 
ATOM   1290 C CG  . ARG A 1 165 ? -0.522  15.316  10.715 1.00 25.88  ? 188 ARG A CG  1 ? 
ATOM   1291 C CD  . ARG A 1 165 ? -1.944  14.842  10.946 1.00 40.74  ? 188 ARG A CD  1 ? 
ATOM   1292 N NE  . ARG A 1 165 ? -2.739  15.749  11.777 1.00 40.93  ? 188 ARG A NE  1 ? 
ATOM   1293 C CZ  . ARG A 1 165 ? -3.441  16.765  11.309 1.00 37.49  ? 188 ARG A CZ  1 ? 
ATOM   1294 N NH1 . ARG A 1 165 ? -3.522  16.966  10.007 1.00 42.33  ? 188 ARG A NH1 1 ? 
ATOM   1295 N NH2 . ARG A 1 165 ? -4.061  17.572  12.145 1.00 33.55  ? 188 ARG A NH2 1 ? 
ATOM   1296 N N   . LYS A 1 166 ? 0.245   16.472  15.282 1.00 15.58  ? 189 LYS A N   1 ? 
ATOM   1297 C CA  . LYS A 1 166 ? 0.691   16.131  16.647 1.00 20.32  ? 189 LYS A CA  1 ? 
ATOM   1298 C C   . LYS A 1 166 ? 0.582   14.605  16.787 1.00 21.95  ? 189 LYS A C   1 ? 
ATOM   1299 O O   . LYS A 1 166 ? -0.514  14.078  16.588 1.00 23.30  ? 189 LYS A O   1 ? 
ATOM   1300 C CB  . LYS A 1 166 ? -0.147  16.909  17.661 1.00 16.36  ? 189 LYS A CB  1 ? 
ATOM   1301 C CG  . LYS A 1 166 ? 0.017   18.411  17.650 1.00 14.20  ? 189 LYS A CG  1 ? 
ATOM   1302 C CD  . LYS A 1 166 ? -1.004  19.022  18.598 1.00 20.89  ? 189 LYS A CD  1 ? 
ATOM   1303 C CE  . LYS A 1 166 ? -1.145  20.495  18.476 1.00 22.35  ? 189 LYS A CE  1 ? 
ATOM   1304 N NZ  . LYS A 1 166 ? -2.064  20.986  19.501 1.00 20.89  ? 189 LYS A NZ  1 ? 
ATOM   1305 N N   . MET A 1 167 ? 1.692   13.955  17.105 1.00 17.41  ? 190 MET A N   1 ? 
ATOM   1306 C CA  . MET A 1 167 ? 1.663   12.491  17.293 1.00 18.05  ? 190 MET A CA  1 ? 
ATOM   1307 C C   . MET A 1 167 ? 2.595   12.105  18.442 1.00 19.20  ? 190 MET A C   1 ? 
ATOM   1308 O O   . MET A 1 167 ? 3.656   12.713  18.589 1.00 15.73  ? 190 MET A O   1 ? 
ATOM   1309 C CB  . MET A 1 167 ? 2.085   11.702  16.050 1.00 16.77  ? 190 MET A CB  1 ? 
ATOM   1310 C CG  . MET A 1 167 ? 1.410   12.092  14.753 1.00 20.31  ? 190 MET A CG  1 ? 
ATOM   1311 S SD  . MET A 1 167 ? 2.112   11.216  13.341 1.00 24.67  ? 190 MET A SD  1 ? 
ATOM   1312 C CE  . MET A 1 167 ? 1.783   9.503   13.765 1.00 24.76  ? 190 MET A CE  1 ? 
ATOM   1313 N N   . SER A 1 168 ? 2.180   11.092  19.182 1.00 18.28  ? 191 SER A N   1 ? 
ATOM   1314 C CA  . SER A 1 168 ? 3.013   10.591  20.297 1.00 19.67  ? 191 SER A CA  1 ? 
ATOM   1315 C C   . SER A 1 168 ? 4.333   10.039  19.733 1.00 16.87  ? 191 SER A C   1 ? 
ATOM   1316 O O   . SER A 1 168 ? 4.314   9.460   18.645 1.00 17.76  ? 191 SER A O   1 ? 
ATOM   1317 C CB  . SER A 1 168 ? 2.239   9.603   21.128 1.00 18.44  ? 191 SER A CB  1 ? 
ATOM   1318 O OG  . SER A 1 168 ? 1.053   10.181  21.651 1.00 23.43  ? 191 SER A OG  1 ? 
ATOM   1319 N N   . PHE A 1 169 ? 5.426   10.199  20.463 1.00 17.73  ? 192 PHE A N   1 ? 
ATOM   1320 C CA  . PHE A 1 169 ? 6.779   9.831   19.955 1.00 17.99  ? 192 PHE A CA  1 ? 
ATOM   1321 C C   . PHE A 1 169 ? 6.844   8.400   19.465 1.00 19.15  ? 192 PHE A C   1 ? 
ATOM   1322 O O   . PHE A 1 169 ? 7.543   8.112   18.508 1.00 18.11  ? 192 PHE A O   1 ? 
ATOM   1323 C CB  . PHE A 1 169 ? 7.780   9.979   21.093 1.00 17.88  ? 192 PHE A CB  1 ? 
ATOM   1324 C CG  . PHE A 1 169 ? 9.245   9.804   20.726 1.00 20.64  ? 192 PHE A CG  1 ? 
ATOM   1325 C CD1 . PHE A 1 169 ? 9.841   10.607  19.763 1.00 17.64  ? 192 PHE A CD1 1 ? 
ATOM   1326 C CD2 . PHE A 1 169 ? 10.025  8.847   21.360 1.00 17.90  ? 192 PHE A CD2 1 ? 
ATOM   1327 C CE1 . PHE A 1 169 ? 11.176  10.450  19.443 1.00 16.15  ? 192 PHE A CE1 1 ? 
ATOM   1328 C CE2 . PHE A 1 169 ? 11.357  8.693   21.032 1.00 14.67  ? 192 PHE A CE2 1 ? 
ATOM   1329 C CZ  . PHE A 1 169 ? 11.925  9.491   20.073 1.00 18.79  ? 192 PHE A CZ  1 ? 
ATOM   1330 N N   . ALA A 1 170 ? 6.148   7.513   20.160 1.00 18.16  ? 193 ALA A N   1 ? 
ATOM   1331 C CA  . ALA A 1 170 ? 6.216   6.085   19.801 1.00 18.31  ? 193 ALA A CA  1 ? 
ATOM   1332 C C   . ALA A 1 170 ? 5.653   5.844   18.401 1.00 20.03  ? 193 ALA A C   1 ? 
ATOM   1333 O O   . ALA A 1 170 ? 6.043   4.855   17.792 1.00 22.58  ? 193 ALA A O   1 ? 
ATOM   1334 C CB  . ALA A 1 170 ? 5.473   5.285   20.827 1.00 20.81  ? 193 ALA A CB  1 ? 
ATOM   1335 N N   . GLU A 1 171 ? 4.793   6.736   17.909 1.00 22.31  ? 194 GLU A N   1 ? 
ATOM   1336 C CA  . GLU A 1 171 ? 4.105   6.474   16.624 1.00 21.28  ? 194 GLU A CA  1 ? 
ATOM   1337 C C   . GLU A 1 171 ? 4.864   7.067   15.436 1.00 24.55  ? 194 GLU A C   1 ? 
ATOM   1338 O O   . GLU A 1 171 ? 4.374   6.929   14.313 1.00 23.92  ? 194 GLU A O   1 ? 
ATOM   1339 C CB  . GLU A 1 171 ? 2.717   7.108   16.712 1.00 23.26  ? 194 GLU A CB  1 ? 
ATOM   1340 C CG  . GLU A 1 171 ? 1.809   6.465   17.757 1.00 25.86  ? 194 GLU A CG  1 ? 
ATOM   1341 C CD  . GLU A 1 171 ? 0.548   7.232   18.126 1.00 35.01  ? 194 GLU A CD  1 ? 
ATOM   1342 O OE1 . GLU A 1 171 ? -0.090  6.853   19.125 1.00 34.47  ? 194 GLU A OE1 1 ? 
ATOM   1343 O OE2 . GLU A 1 171 ? 0.189   8.200   17.433 1.00 31.46  ? 194 GLU A OE2 1 ? 
ATOM   1344 N N   . VAL A 1 172 ? 6.010   7.692   15.684 1.00 20.91  ? 195 VAL A N   1 ? 
ATOM   1345 C CA  . VAL A 1 172 ? 6.695   8.426   14.586 1.00 18.22  ? 195 VAL A CA  1 ? 
ATOM   1346 C C   . VAL A 1 172 ? 7.155   7.469   13.475 1.00 19.76  ? 195 VAL A C   1 ? 
ATOM   1347 O O   . VAL A 1 172 ? 6.914   7.771   12.303 1.00 18.39  ? 195 VAL A O   1 ? 
ATOM   1348 C CB  . VAL A 1 172 ? 7.857   9.273   15.139 1.00 18.72  ? 195 VAL A CB  1 ? 
ATOM   1349 C CG1 . VAL A 1 172 ? 8.549   10.061  14.033 1.00 19.83  ? 195 VAL A CG1 1 ? 
ATOM   1350 C CG2 . VAL A 1 172 ? 7.392   10.220  16.231 1.00 16.90  ? 195 VAL A CG2 1 ? 
ATOM   1351 N N   . TYR A 1 173 ? 7.798   6.367   13.844 1.00 18.15  ? 196 TYR A N   1 ? 
ATOM   1352 C CA  . TYR A 1 173 ? 8.384   5.507   12.785 1.00 19.56  ? 196 TYR A CA  1 ? 
ATOM   1353 C C   . TYR A 1 173 ? 7.303   5.064   11.821 1.00 18.90  ? 196 TYR A C   1 ? 
ATOM   1354 O O   . TYR A 1 173 ? 7.472   5.205   10.616 1.00 18.77  ? 196 TYR A O   1 ? 
ATOM   1355 C CB  . TYR A 1 173 ? 9.088   4.291   13.385 1.00 18.90  ? 196 TYR A CB  1 ? 
ATOM   1356 C CG  . TYR A 1 173 ? 9.868   3.459   12.378 1.00 22.13  ? 196 TYR A CG  1 ? 
ATOM   1357 C CD1 . TYR A 1 173 ? 9.218   2.588   11.514 1.00 23.79  ? 196 TYR A CD1 1 ? 
ATOM   1358 C CD2 . TYR A 1 173 ? 11.251  3.529   12.307 1.00 21.28  ? 196 TYR A CD2 1 ? 
ATOM   1359 C CE1 . TYR A 1 173 ? 9.914   1.825   10.597 1.00 26.80  ? 196 TYR A CE1 1 ? 
ATOM   1360 C CE2 . TYR A 1 173 ? 11.962  2.769   11.395 1.00 22.80  ? 196 TYR A CE2 1 ? 
ATOM   1361 C CZ  . TYR A 1 173 ? 11.291  1.916   10.537 1.00 26.37  ? 196 TYR A CZ  1 ? 
ATOM   1362 O OH  . TYR A 1 173 ? 11.965  1.154   9.637  1.00 24.93  ? 196 TYR A OH  1 ? 
ATOM   1363 N N   . GLN A 1 174 ? 6.237   4.499   12.370 1.00 21.71  ? 197 GLN A N   1 ? 
ATOM   1364 C CA  . GLN A 1 174 ? 5.134   3.966   11.543 1.00 21.42  ? 197 GLN A CA  1 ? 
ATOM   1365 C C   . GLN A 1 174 ? 4.483   5.096   10.730 1.00 23.00  ? 197 GLN A C   1 ? 
ATOM   1366 O O   . GLN A 1 174 ? 4.212   4.874   9.568  1.00 20.46  ? 197 GLN A O   1 ? 
ATOM   1367 C CB  . GLN A 1 174 ? 4.157   3.263   12.478 1.00 24.46  ? 197 GLN A CB  1 ? 
ATOM   1368 C CG  . GLN A 1 174 ? 3.665   1.905   11.994 1.00 46.74  ? 197 GLN A CG  1 ? 
ATOM   1369 C CD  . GLN A 1 174 ? 4.759   0.977   11.515 1.00 65.11  ? 197 GLN A CD  1 ? 
ATOM   1370 O OE1 . GLN A 1 174 ? 5.832   0.863   12.117 1.00 59.88  ? 197 GLN A OE1 1 ? 
ATOM   1371 N NE2 . GLN A 1 174 ? 4.483   0.282   10.423 1.00 72.40  ? 197 GLN A NE2 1 ? 
ATOM   1372 N N   . GLY A 1 175 ? 4.277   6.257   11.349 1.00 18.19  ? 198 GLY A N   1 ? 
ATOM   1373 C CA  . GLY A 1 175 ? 3.647   7.392   10.657 1.00 14.54  ? 198 GLY A CA  1 ? 
ATOM   1374 C C   . GLY A 1 175 ? 4.417   7.758   9.409  1.00 16.59  ? 198 GLY A C   1 ? 
ATOM   1375 O O   . GLY A 1 175 ? 3.792   8.096   8.401  1.00 16.24  ? 198 GLY A O   1 ? 
ATOM   1376 N N   . LEU A 1 176 ? 5.739   7.677   9.492  1.00 19.48  ? 199 LEU A N   1 ? 
ATOM   1377 C CA  . LEU A 1 176 ? 6.608   8.064   8.359  1.00 18.18  ? 199 LEU A CA  1 ? 
ATOM   1378 C C   . LEU A 1 176 ? 6.668   6.918   7.342  1.00 22.84  ? 199 LEU A C   1 ? 
ATOM   1379 O O   . LEU A 1 176 ? 6.588   7.184   6.147  1.00 23.10  ? 199 LEU A O   1 ? 
ATOM   1380 C CB  . LEU A 1 176 ? 7.979   8.422   8.925  1.00 21.91  ? 199 LEU A CB  1 ? 
ATOM   1381 C CG  . LEU A 1 176 ? 8.060   9.763   9.658  1.00 20.76  ? 199 LEU A CG  1 ? 
ATOM   1382 C CD1 . LEU A 1 176 ? 9.319   9.882   10.486 1.00 20.25  ? 199 LEU A CD1 1 ? 
ATOM   1383 C CD2 . LEU A 1 176 ? 7.978   10.892  8.660  1.00 17.47  ? 199 LEU A CD2 1 ? 
ATOM   1384 N N   . GLN A 1 177 ? 6.776   5.694   7.836  1.00 22.74  ? 200 GLN A N   1 ? 
ATOM   1385 C CA  . GLN A 1 177 ? 6.858   4.524   6.932  1.00 25.02  ? 200 GLN A CA  1 ? 
ATOM   1386 C C   . GLN A 1 177 ? 5.572   4.419   6.110  1.00 25.93  ? 200 GLN A C   1 ? 
ATOM   1387 O O   . GLN A 1 177 ? 5.673   4.054   4.945  1.00 28.40  ? 200 GLN A O   1 ? 
ATOM   1388 C CB  . GLN A 1 177 ? 7.069   3.271   7.778  1.00 23.41  ? 200 GLN A CB  1 ? 
ATOM   1389 C CG  . GLN A 1 177 ? 7.392   2.011   6.990  1.00 25.66  ? 200 GLN A CG  1 ? 
ATOM   1390 C CD  . GLN A 1 177 ? 7.357   0.780   7.864  1.00 39.67  ? 200 GLN A CD  1 ? 
ATOM   1391 O OE1 . GLN A 1 177 ? 6.333   0.456   8.470  1.00 50.44  ? 200 GLN A OE1 1 ? 
ATOM   1392 N NE2 . GLN A 1 177 ? 8.486   0.094   7.958  1.00 45.35  ? 200 GLN A NE2 1 ? 
ATOM   1393 N N   . THR A 1 178 ? 4.426   4.753   6.704  1.00 27.50  ? 201 THR A N   1 ? 
ATOM   1394 C CA  . THR A 1 178 ? 3.110   4.609   6.056  1.00 22.29  ? 201 THR A CA  1 ? 
ATOM   1395 C C   . THR A 1 178 ? 2.671   5.881   5.364  1.00 25.92  ? 201 THR A C   1 ? 
ATOM   1396 O O   . THR A 1 178 ? 1.668   5.815   4.662  1.00 32.33  ? 201 THR A O   1 ? 
ATOM   1397 C CB  . THR A 1 178 ? 2.091   4.171   7.111  1.00 20.49  ? 201 THR A CB  1 ? 
ATOM   1398 O OG1 . THR A 1 178 ? 2.016   5.212   8.075  1.00 19.64  ? 201 THR A OG1 1 ? 
ATOM   1399 C CG2 . THR A 1 178 ? 2.458   2.839   7.739  1.00 18.77  ? 201 THR A CG2 1 ? 
ATOM   1400 N N   . GLY A 1 179 ? 3.348   7.003   5.570  1.00 26.37  ? 202 GLY A N   1 ? 
ATOM   1401 C CA  . GLY A 1 179 ? 3.022   8.238   4.822  1.00 21.77  ? 202 GLY A CA  1 ? 
ATOM   1402 C C   . GLY A 1 179 ? 1.978   9.118   5.497  1.00 23.16  ? 202 GLY A C   1 ? 
ATOM   1403 O O   . GLY A 1 179 ? 1.535   10.081  4.871  1.00 21.25  ? 202 GLY A O   1 ? 
ATOM   1404 N N   . VAL A 1 180 ? 1.575   8.780   6.721  1.00 23.80  ? 203 VAL A N   1 ? 
ATOM   1405 C CA  . VAL A 1 180 ? 0.663   9.673   7.484  1.00 20.80  ? 203 VAL A CA  1 ? 
ATOM   1406 C C   . VAL A 1 180 ? 1.412   11.001  7.589  1.00 20.11  ? 203 VAL A C   1 ? 
ATOM   1407 O O   . VAL A 1 180 ? 0.778   12.054  7.470  1.00 22.81  ? 203 VAL A O   1 ? 
ATOM   1408 C CB  . VAL A 1 180 ? 0.393   9.058   8.863  1.00 21.00  ? 203 VAL A CB  1 ? 
ATOM   1409 C CG1 . VAL A 1 180 ? -0.313  10.019  9.807  1.00 22.24  ? 203 VAL A CG1 1 ? 
ATOM   1410 C CG2 . VAL A 1 180 ? -0.328  7.722   8.764  1.00 22.52  ? 203 VAL A CG2 1 ? 
ATOM   1411 N N   . VAL A 1 181 ? 2.711   10.907  7.823  1.00 18.45  ? 204 VAL A N   1 ? 
ATOM   1412 C CA  . VAL A 1 181 ? 3.580   12.107  7.846  1.00 20.72  ? 204 VAL A CA  1 ? 
ATOM   1413 C C   . VAL A 1 181 ? 4.709   11.861  6.834  1.00 23.59  ? 204 VAL A C   1 ? 
ATOM   1414 O O   . VAL A 1 181 ? 4.976   10.694  6.535  1.00 21.17  ? 204 VAL A O   1 ? 
ATOM   1415 C CB  . VAL A 1 181 ? 4.116   12.422  9.255  1.00 19.75  ? 204 VAL A CB  1 ? 
ATOM   1416 C CG1 . VAL A 1 181 ? 3.141   13.296  10.031 1.00 21.43  ? 204 VAL A CG1 1 ? 
ATOM   1417 C CG2 . VAL A 1 181 ? 4.435   11.161  10.041 1.00 22.53  ? 204 VAL A CG2 1 ? 
ATOM   1418 N N   . ASN A 1 182 ? 5.304   12.935  6.323  1.00 21.53  ? 205 ASN A N   1 ? 
ATOM   1419 C CA  . ASN A 1 182 ? 6.397   12.848  5.324  1.00 22.49  ? 205 ASN A CA  1 ? 
ATOM   1420 C C   . ASN A 1 182 ? 7.710   13.340  5.946  1.00 20.07  ? 205 ASN A C   1 ? 
ATOM   1421 O O   . ASN A 1 182 ? 8.777   13.011  5.433  1.00 20.91  ? 205 ASN A O   1 ? 
ATOM   1422 C CB  . ASN A 1 182 ? 6.136   13.775  4.140  1.00 28.27  ? 205 ASN A CB  1 ? 
ATOM   1423 C CG  . ASN A 1 182 ? 4.708   13.767  3.656  1.00 39.33  ? 205 ASN A CG  1 ? 
ATOM   1424 O OD1 . ASN A 1 182 ? 4.127   14.832  3.442  1.00 52.93  ? 205 ASN A OD1 1 ? 
ATOM   1425 N ND2 . ASN A 1 182 ? 4.134   12.592  3.449  1.00 56.58  ? 205 ASN A ND2 1 ? 
ATOM   1426 N N   . GLY A 1 183 ? 7.610   14.158  6.987  1.00 19.16  ? 206 GLY A N   1 ? 
ATOM   1427 C CA  . GLY A 1 183 ? 8.814   14.655  7.654  1.00 16.72  ? 206 GLY A CA  1 ? 
ATOM   1428 C C   . GLY A 1 183 ? 8.610   14.892  9.134  1.00 19.55  ? 206 GLY A C   1 ? 
ATOM   1429 O O   . GLY A 1 183 ? 7.491   14.671  9.612  1.00 23.15  ? 206 GLY A O   1 ? 
ATOM   1430 N N   . THR A 1 184 ? 9.664   15.321  9.820  1.00 17.47  ? 207 THR A N   1 ? 
ATOM   1431 C CA  . THR A 1 184 ? 9.526   15.684  11.244 1.00 15.59  ? 207 THR A CA  1 ? 
ATOM   1432 C C   . THR A 1 184 ? 10.708  16.531  11.690 1.00 18.58  ? 207 THR A C   1 ? 
ATOM   1433 O O   . THR A 1 184 ? 11.443  17.040  10.842 1.00 17.29  ? 207 THR A O   1 ? 
ATOM   1434 C CB  . THR A 1 184 ? 9.356   14.436  12.126 1.00 16.52  ? 207 THR A CB  1 ? 
ATOM   1435 O OG1 . THR A 1 184 ? 9.033   14.855  13.447 1.00 19.54  ? 207 THR A OG1 1 ? 
ATOM   1436 C CG2 . THR A 1 184 ? 10.595  13.560  12.163 1.00 17.53  ? 207 THR A CG2 1 ? 
ATOM   1437 N N   . GLU A 1 185 ? 10.833  16.706  12.999 1.00 16.77  ? 208 GLU A N   1 ? 
ATOM   1438 C CA  . GLU A 1 185 ? 11.953  17.458  13.596 1.00 14.37  ? 208 GLU A CA  1 ? 
ATOM   1439 C C   . GLU A 1 185 ? 12.344  16.692  14.865 1.00 15.93  ? 208 GLU A C   1 ? 
ATOM   1440 O O   . GLU A 1 185 ? 11.443  16.184  15.528 1.00 17.77  ? 208 GLU A O   1 ? 
ATOM   1441 C CB  . GLU A 1 185 ? 11.555  18.884  13.974 1.00 13.94  ? 208 GLU A CB  1 ? 
ATOM   1442 C CG  . GLU A 1 185 ? 10.245  19.008  14.742 1.00 17.33  ? 208 GLU A CG  1 ? 
ATOM   1443 C CD  . GLU A 1 185 ? 10.139  20.326  15.487 1.00 17.72  ? 208 GLU A CD  1 ? 
ATOM   1444 O OE1 . GLU A 1 185 ? 9.391   20.390  16.474 1.00 21.81  ? 208 GLU A OE1 1 ? 
ATOM   1445 O OE2 . GLU A 1 185 ? 10.815  21.286  15.084 1.00 17.21  ? 208 GLU A OE2 1 ? 
ATOM   1446 N N   . ASN A 1 186 ? 13.641  16.602  15.136 1.00 17.23  ? 209 ASN A N   1 ? 
ATOM   1447 C CA  . ASN A 1 186 ? 14.113  15.931  16.373 1.00 16.37  ? 209 ASN A CA  1 ? 
ATOM   1448 C C   . ASN A 1 186 ? 15.628  16.036  16.549 1.00 16.22  ? 209 ASN A C   1 ? 
ATOM   1449 O O   . ASN A 1 186 ? 16.299  16.577  15.679 1.00 16.92  ? 209 ASN A O   1 ? 
ATOM   1450 C CB  . ASN A 1 186 ? 13.683  14.467  16.453 1.00 14.50  ? 209 ASN A CB  1 ? 
ATOM   1451 C CG  . ASN A 1 186 ? 13.078  14.147  17.798 1.00 16.41  ? 209 ASN A CG  1 ? 
ATOM   1452 O OD1 . ASN A 1 186 ? 13.724  14.351  18.827 1.00 14.43  ? 209 ASN A OD1 1 ? 
ATOM   1453 N ND2 . ASN A 1 186 ? 11.846  13.663  17.809 1.00 14.93  ? 209 ASN A ND2 1 ? 
ATOM   1454 N N   . THR A 1 187 ? 16.106  15.521  17.672 1.00 14.37  ? 210 THR A N   1 ? 
ATOM   1455 C CA  . THR A 1 187 ? 17.544  15.487  17.941 1.00 15.64  ? 210 THR A CA  1 ? 
ATOM   1456 C C   . THR A 1 187 ? 18.133  14.300  17.217 1.00 15.45  ? 210 THR A C   1 ? 
ATOM   1457 O O   . THR A 1 187 ? 17.420  13.319  17.029 1.00 14.70  ? 210 THR A O   1 ? 
ATOM   1458 C CB  . THR A 1 187 ? 17.776  15.330  19.445 1.00 16.90  ? 210 THR A CB  1 ? 
ATOM   1459 O OG1 . THR A 1 187 ? 17.351  14.022  19.805 1.00 16.52  ? 210 THR A OG1 1 ? 
ATOM   1460 C CG2 . THR A 1 187 ? 17.039  16.385  20.250 1.00 17.21  ? 210 THR A CG2 1 ? 
ATOM   1461 N N   . TRP A 1 188 ? 19.430  14.367  16.912 1.00 17.15  ? 211 TRP A N   1 ? 
ATOM   1462 C CA  . TRP A 1 188 ? 20.107  13.203  16.296 1.00 16.49  ? 211 TRP A CA  1 ? 
ATOM   1463 C C   . TRP A 1 188 ? 19.849  11.956  17.161 1.00 18.48  ? 211 TRP A C   1 ? 
ATOM   1464 O O   . TRP A 1 188 ? 19.562  10.908  16.592 1.00 15.34  ? 211 TRP A O   1 ? 
ATOM   1465 C CB  . TRP A 1 188 ? 21.612  13.449  16.102 1.00 13.90  ? 211 TRP A CB  1 ? 
ATOM   1466 C CG  . TRP A 1 188 ? 22.004  14.626  15.250 1.00 14.41  ? 211 TRP A CG  1 ? 
ATOM   1467 C CD1 . TRP A 1 188 ? 22.796  15.667  15.634 1.00 13.51  ? 211 TRP A CD1 1 ? 
ATOM   1468 C CD2 . TRP A 1 188 ? 21.669  14.869  13.866 1.00 16.10  ? 211 TRP A CD2 1 ? 
ATOM   1469 N NE1 . TRP A 1 188 ? 22.970  16.543  14.600 1.00 17.16  ? 211 TRP A NE1 1 ? 
ATOM   1470 C CE2 . TRP A 1 188 ? 22.293  16.083  13.502 1.00 17.40  ? 211 TRP A CE2 1 ? 
ATOM   1471 C CE3 . TRP A 1 188 ? 20.905  14.195  12.909 1.00 17.38  ? 211 TRP A CE3 1 ? 
ATOM   1472 C CZ2 . TRP A 1 188 ? 22.174  16.627  12.227 1.00 17.85  ? 211 TRP A CZ2 1 ? 
ATOM   1473 C CZ3 . TRP A 1 188 ? 20.786  14.737  11.651 1.00 18.37  ? 211 TRP A CZ3 1 ? 
ATOM   1474 C CH2 . TRP A 1 188 ? 21.414  15.934  11.315 1.00 22.31  ? 211 TRP A CH2 1 ? 
ATOM   1475 N N   . SER A 1 189 ? 19.947  12.082  18.489 1.00 13.80  ? 212 SER A N   1 ? 
ATOM   1476 C CA  . SER A 1 189 ? 19.783  10.879  19.350 1.00 15.43  ? 212 SER A CA  1 ? 
ATOM   1477 C C   . SER A 1 189 ? 18.437  10.204  19.072 1.00 17.30  ? 212 SER A C   1 ? 
ATOM   1478 O O   . SER A 1 189 ? 18.413  8.995   18.916 1.00 16.68  ? 212 SER A O   1 ? 
ATOM   1479 C CB  . SER A 1 189 ? 19.898  11.157  20.841 1.00 14.98  ? 212 SER A CB  1 ? 
ATOM   1480 O OG  . SER A 1 189 ? 19.556  10.034  21.630 1.00 16.17  ? 212 SER A OG  1 ? 
ATOM   1481 N N   . ASN A 1 190 ? 17.365  10.987  19.058 1.00 15.40  ? 213 ASN A N   1 ? 
ATOM   1482 C CA  . ASN A 1 190 ? 16.016  10.380  18.914 1.00 14.97  ? 213 ASN A CA  1 ? 
ATOM   1483 C C   . ASN A 1 190 ? 15.877  9.731   17.528 1.00 15.12  ? 213 ASN A C   1 ? 
ATOM   1484 O O   . ASN A 1 190 ? 15.321  8.654   17.417 1.00 18.27  ? 213 ASN A O   1 ? 
ATOM   1485 C CB  . ASN A 1 190 ? 14.929  11.396  19.205 1.00 14.39  ? 213 ASN A CB  1 ? 
ATOM   1486 C CG  . ASN A 1 190 ? 14.604  11.500  20.675 1.00 16.98  ? 213 ASN A CG  1 ? 
ATOM   1487 O OD1 . ASN A 1 190 ? 14.904  10.584  21.443 1.00 17.59  ? 213 ASN A OD1 1 ? 
ATOM   1488 N ND2 . ASN A 1 190 ? 13.988  12.599  21.081 1.00 13.58  ? 213 ASN A ND2 1 ? 
ATOM   1489 N N   . TYR A 1 191 ? 16.401  10.394  16.519 1.00 16.12  ? 214 TYR A N   1 ? 
ATOM   1490 C CA  . TYR A 1 191 ? 16.299  9.842   15.144 1.00 15.46  ? 214 TYR A CA  1 ? 
ATOM   1491 C C   . TYR A 1 191 ? 16.997  8.479   15.058 1.00 14.12  ? 214 TYR A C   1 ? 
ATOM   1492 O O   . TYR A 1 191 ? 16.388  7.501   14.650 1.00 18.88  ? 214 TYR A O   1 ? 
ATOM   1493 C CB  . TYR A 1 191 ? 16.938  10.852  14.209 1.00 14.12  ? 214 TYR A CB  1 ? 
ATOM   1494 C CG  . TYR A 1 191 ? 16.041  11.970  13.700 1.00 18.64  ? 214 TYR A CG  1 ? 
ATOM   1495 C CD1 . TYR A 1 191 ? 14.857  11.687  13.038 1.00 18.80  ? 214 TYR A CD1 1 ? 
ATOM   1496 C CD2 . TYR A 1 191 ? 16.403  13.302  13.845 1.00 18.27  ? 214 TYR A CD2 1 ? 
ATOM   1497 C CE1 . TYR A 1 191 ? 14.050  12.695  12.545 1.00 20.12  ? 214 TYR A CE1 1 ? 
ATOM   1498 C CE2 . TYR A 1 191 ? 15.605  14.320  13.353 1.00 21.02  ? 214 TYR A CE2 1 ? 
ATOM   1499 C CZ  . TYR A 1 191 ? 14.426  14.015  12.700 1.00 21.14  ? 214 TYR A CZ  1 ? 
ATOM   1500 O OH  . TYR A 1 191 ? 13.625  15.002  12.215 1.00 17.89  ? 214 TYR A OH  1 ? 
ATOM   1501 N N   . GLU A 1 192 ? 18.261  8.436   15.456 1.00 16.92  ? 215 GLU A N   1 ? 
ATOM   1502 C CA  . GLU A 1 192 ? 19.046  7.181   15.312 1.00 17.50  ? 215 GLU A CA  1 ? 
ATOM   1503 C C   . GLU A 1 192 ? 18.537  6.112   16.289 1.00 16.77  ? 215 GLU A C   1 ? 
ATOM   1504 O O   . GLU A 1 192 ? 18.366  4.971   15.867 1.00 15.69  ? 215 GLU A O   1 ? 
ATOM   1505 C CB  . GLU A 1 192 ? 20.543  7.438   15.488 1.00 22.28  ? 215 GLU A CB  1 ? 
ATOM   1506 C CG  . GLU A 1 192 ? 21.437  6.313   14.982 1.00 17.20  ? 215 GLU A CG  1 ? 
ATOM   1507 C CD  . GLU A 1 192 ? 21.685  5.234   16.019 1.00 23.77  ? 215 GLU A CD  1 ? 
ATOM   1508 O OE1 . GLU A 1 192 ? 22.079  4.130   15.620 1.00 25.81  ? 215 GLU A OE1 1 ? 
ATOM   1509 O OE2 . GLU A 1 192 ? 21.477  5.496   17.216 1.00 19.27  ? 215 GLU A OE2 1 ? 
ATOM   1510 N N   . SER A 1 193 ? 18.334  6.493   17.551 1.00 16.16  ? 216 SER A N   1 ? 
ATOM   1511 C CA  . SER A 1 193 ? 17.880  5.521   18.578 1.00 15.15  ? 216 SER A CA  1 ? 
ATOM   1512 C C   . SER A 1 193 ? 16.578  4.824   18.139 1.00 17.04  ? 216 SER A C   1 ? 
ATOM   1513 O O   . SER A 1 193 ? 16.383  3.679   18.542 1.00 18.02  ? 216 SER A O   1 ? 
ATOM   1514 C CB  . SER A 1 193 ? 17.726  6.181   19.946 1.00 17.09  ? 216 SER A CB  1 ? 
ATOM   1515 O OG  . SER A 1 193 ? 16.817  7.267   19.934 1.00 18.98  ? 216 SER A OG  1 ? 
ATOM   1516 N N   . GLN A 1 194 ? 15.720  5.514   17.382 1.00 15.74  ? 217 GLN A N   1 ? 
ATOM   1517 C CA  . GLN A 1 194 ? 14.410  4.952   16.956 1.00 16.53  ? 217 GLN A CA  1 ? 
ATOM   1518 C C   . GLN A 1 194 ? 14.486  4.499   15.481 1.00 17.13  ? 217 GLN A C   1 ? 
ATOM   1519 O O   . GLN A 1 194 ? 13.448  4.152   14.927 1.00 20.15  ? 217 GLN A O   1 ? 
ATOM   1520 C CB  . GLN A 1 194 ? 13.287  5.955   17.228 1.00 17.09  ? 217 GLN A CB  1 ? 
ATOM   1521 C CG  . GLN A 1 194 ? 13.117  6.329   18.697 1.00 13.95  ? 217 GLN A CG  1 ? 
ATOM   1522 C CD  . GLN A 1 194 ? 12.573  5.207   19.557 1.00 21.18  ? 217 GLN A CD  1 ? 
ATOM   1523 O OE1 . GLN A 1 194 ? 11.981  4.241   19.068 1.00 21.36  ? 217 GLN A OE1 1 ? 
ATOM   1524 N NE2 . GLN A 1 194 ? 12.767  5.331   20.860 1.00 16.33  ? 217 GLN A NE2 1 ? 
ATOM   1525 N N   . LYS A 1 195 ? 15.676  4.535   14.893 1.00 20.46  ? 218 LYS A N   1 ? 
ATOM   1526 C CA  . LYS A 1 195 ? 15.901  4.067   13.498 1.00 21.12  ? 218 LYS A CA  1 ? 
ATOM   1527 C C   . LYS A 1 195 ? 15.077  4.881   12.486 1.00 17.86  ? 218 LYS A C   1 ? 
ATOM   1528 O O   . LYS A 1 195 ? 14.855  4.387   11.387 1.00 19.55  ? 218 LYS A O   1 ? 
ATOM   1529 C CB  . LYS A 1 195 ? 15.633  2.563   13.421 1.00 20.57  ? 218 LYS A CB  1 ? 
ATOM   1530 C CG  . LYS A 1 195 ? 16.681  1.736   14.134 1.00 22.31  ? 218 LYS A CG  1 ? 
ATOM   1531 C CD  . LYS A 1 195 ? 16.252  0.291   14.331 1.00 32.37  ? 218 LYS A CD  1 ? 
ATOM   1532 C CE  . LYS A 1 195 ? 17.374  -0.660  14.095 1.00 30.51  ? 218 LYS A CE  1 ? 
ATOM   1533 N NZ  . LYS A 1 195 ? 16.864  -1.953  13.638 1.00 45.23  ? 218 LYS A NZ  1 ? 
ATOM   1534 N N   . VAL A 1 196 ? 14.670  6.094   12.847 1.00 19.20  ? 219 VAL A N   1 ? 
ATOM   1535 C CA  . VAL A 1 196 ? 13.797  6.899   11.939 1.00 15.36  ? 219 VAL A CA  1 ? 
ATOM   1536 C C   . VAL A 1 196 ? 14.558  7.290   10.648 1.00 21.01  ? 219 VAL A C   1 ? 
ATOM   1537 O O   . VAL A 1 196 ? 13.892  7.576   9.655  1.00 22.09  ? 219 VAL A O   1 ? 
ATOM   1538 C CB  . VAL A 1 196 ? 13.190  8.084   12.714 1.00 18.06  ? 219 VAL A CB  1 ? 
ATOM   1539 C CG1 . VAL A 1 196 ? 12.581  9.162   11.828 1.00 13.40  ? 219 VAL A CG1 1 ? 
ATOM   1540 C CG2 . VAL A 1 196 ? 12.182  7.607   13.752 1.00 14.57  ? 219 VAL A CG2 1 ? 
ATOM   1541 N N   . ASN A 1 197 ? 15.893  7.272   10.653 1.00 21.45  ? 220 ASN A N   1 ? 
ATOM   1542 C CA  . ASN A 1 197 ? 16.705  7.537   9.429  1.00 19.82  ? 220 ASN A CA  1 ? 
ATOM   1543 C C   . ASN A 1 197 ? 16.377  6.506   8.338  1.00 20.75  ? 220 ASN A C   1 ? 
ATOM   1544 O O   . ASN A 1 197 ? 16.559  6.812   7.163  1.00 16.32  ? 220 ASN A O   1 ? 
ATOM   1545 C CB  . ASN A 1 197 ? 18.197  7.568   9.737  1.00 20.36  ? 220 ASN A CB  1 ? 
ATOM   1546 C CG  . ASN A 1 197 ? 18.675  6.360   10.503 1.00 28.68  ? 220 ASN A CG  1 ? 
ATOM   1547 O OD1 . ASN A 1 197 ? 18.314  6.178   11.668 1.00 23.01  ? 220 ASN A OD1 1 ? 
ATOM   1548 N ND2 . ASN A 1 197 ? 19.501  5.539   9.874  1.00 25.95  ? 220 ASN A ND2 1 ? 
ATOM   1549 N N   . GLU A 1 198 ? 15.879  5.338   8.741  1.00 24.15  ? 221 GLU A N   1 ? 
ATOM   1550 C CA  . GLU A 1 198 ? 15.482  4.289   7.766  1.00 22.90  ? 221 GLU A CA  1 ? 
ATOM   1551 C C   . GLU A 1 198 ? 14.259  4.751   6.963  1.00 24.29  ? 221 GLU A C   1 ? 
ATOM   1552 O O   . GLU A 1 198 ? 14.006  4.166   5.915  1.00 22.51  ? 221 GLU A O   1 ? 
ATOM   1553 C CB  . GLU A 1 198 ? 15.130  2.963   8.432  1.00 21.87  ? 221 GLU A CB  1 ? 
ATOM   1554 C CG  . GLU A 1 198 ? 16.284  2.321   9.190  1.00 24.20  ? 221 GLU A CG  1 ? 
ATOM   1555 C CD  . GLU A 1 198 ? 15.863  1.039   9.881  1.00 24.51  ? 221 GLU A CD  1 ? 
ATOM   1556 O OE1 . GLU A 1 198 ? 16.744  0.312   10.357 1.00 27.29  ? 221 GLU A OE1 1 ? 
ATOM   1557 O OE2 . GLU A 1 198 ? 14.653  0.770   9.936  1.00 32.19  ? 221 GLU A OE2 1 ? 
ATOM   1558 N N   . VAL A 1 199 ? 13.541  5.755   7.458  1.00 19.55  ? 222 VAL A N   1 ? 
ATOM   1559 C CA  . VAL A 1 199 ? 12.287  6.218   6.796  1.00 22.88  ? 222 VAL A CA  1 ? 
ATOM   1560 C C   . VAL A 1 199 ? 12.393  7.724   6.504  1.00 18.99  ? 222 VAL A C   1 ? 
ATOM   1561 O O   . VAL A 1 199 ? 11.360  8.347   6.256  1.00 22.14  ? 222 VAL A O   1 ? 
ATOM   1562 C CB  . VAL A 1 199 ? 11.030  5.861   7.617  1.00 20.93  ? 222 VAL A CB  1 ? 
ATOM   1563 C CG1 . VAL A 1 199 ? 10.791  4.358   7.646  1.00 23.00  ? 222 VAL A CG1 1 ? 
ATOM   1564 C CG2 . VAL A 1 199 ? 11.057  6.422   9.030  1.00 17.84  ? 222 VAL A CG2 1 ? 
ATOM   1565 N N   . GLN A 1 200 ? 13.607  8.253   6.543  1.00 18.55  ? 223 GLN A N   1 ? 
ATOM   1566 C CA  . GLN A 1 200 ? 13.835  9.673   6.189  1.00 18.74  ? 223 GLN A CA  1 ? 
ATOM   1567 C C   . GLN A 1 200 ? 15.158  9.735   5.416  1.00 21.17  ? 223 GLN A C   1 ? 
ATOM   1568 O O   . GLN A 1 200 ? 16.192  9.535   6.033  1.00 21.92  ? 223 GLN A O   1 ? 
ATOM   1569 C CB  . GLN A 1 200 ? 13.839  10.602  7.402  1.00 15.94  ? 223 GLN A CB  1 ? 
ATOM   1570 C CG  . GLN A 1 200 ? 12.521  10.653  8.164  1.00 21.46  ? 223 GLN A CG  1 ? 
ATOM   1571 C CD  . GLN A 1 200 ? 11.502  11.596  7.562  1.00 21.16  ? 223 GLN A CD  1 ? 
ATOM   1572 O OE1 . GLN A 1 200 ? 11.287  12.703  8.060  1.00 14.79  ? 223 GLN A OE1 1 ? 
ATOM   1573 N NE2 . GLN A 1 200 ? 10.850  11.160  6.496  1.00 14.95  ? 223 GLN A NE2 1 ? 
ATOM   1574 N N   . LYS A 1 201 ? 15.090  10.042  4.121  1.00 23.93  ? 224 LYS A N   1 ? 
ATOM   1575 C CA  . LYS A 1 201 ? 16.290  10.079  3.253  1.00 24.19  ? 224 LYS A CA  1 ? 
ATOM   1576 C C   . LYS A 1 201 ? 17.041  11.404  3.389  1.00 24.99  ? 224 LYS A C   1 ? 
ATOM   1577 O O   . LYS A 1 201 ? 18.220  11.444  3.032  1.00 27.80  ? 224 LYS A O   1 ? 
ATOM   1578 C CB  . LYS A 1 201 ? 15.868  9.976   1.787  1.00 27.96  ? 224 LYS A CB  1 ? 
ATOM   1579 C CG  . LYS A 1 201 ? 14.752  8.987   1.509  1.00 41.97  ? 224 LYS A CG  1 ? 
ATOM   1580 C CD  . LYS A 1 201 ? 13.870  9.390   0.333  1.00 59.57  ? 224 LYS A CD  1 ? 
ATOM   1581 C CE  . LYS A 1 201 ? 12.799  8.383   0.073  1.00 60.37  ? 224 LYS A CE  1 ? 
ATOM   1582 N NZ  . LYS A 1 201 ? 12.221  8.531   -1.265 1.00 64.72  ? 224 LYS A NZ  1 ? 
ATOM   1583 N N   . TYR A 1 202 ? 16.358  12.444  3.845  1.00 19.71  ? 225 TYR A N   1 ? 
ATOM   1584 C CA  . TYR A 1 202 ? 17.014  13.763  3.894  1.00 19.39  ? 225 TYR A CA  1 ? 
ATOM   1585 C C   . TYR A 1 202 ? 16.933  14.365  5.284  1.00 23.57  ? 225 TYR A C   1 ? 
ATOM   1586 O O   . TYR A 1 202 ? 15.856  14.431  5.868  1.00 23.83  ? 225 TYR A O   1 ? 
ATOM   1587 C CB  . TYR A 1 202 ? 16.393  14.663  2.829  1.00 20.19  ? 225 TYR A CB  1 ? 
ATOM   1588 C CG  . TYR A 1 202 ? 16.595  14.153  1.413  1.00 26.40  ? 225 TYR A CG  1 ? 
ATOM   1589 C CD1 . TYR A 1 202 ? 17.793  14.361  0.745  1.00 36.26  ? 225 TYR A CD1 1 ? 
ATOM   1590 C CD2 . TYR A 1 202 ? 15.595  13.454  0.755  1.00 25.46  ? 225 TYR A CD2 1 ? 
ATOM   1591 C CE1 . TYR A 1 202 ? 17.985  13.896  -0.543 1.00 31.98  ? 225 TYR A CE1 1 ? 
ATOM   1592 C CE2 . TYR A 1 202 ? 15.775  12.983  -0.532 1.00 26.31  ? 225 TYR A CE2 1 ? 
ATOM   1593 C CZ  . TYR A 1 202 ? 16.974  13.204  -1.181 1.00 29.84  ? 225 TYR A CZ  1 ? 
ATOM   1594 O OH  . TYR A 1 202 ? 17.163  12.745  -2.448 1.00 32.70  ? 225 TYR A OH  1 ? 
ATOM   1595 N N   . PHE A 1 203 ? 18.079  14.810  5.775  1.00 22.98  ? 226 PHE A N   1 ? 
ATOM   1596 C CA  . PHE A 1 203 ? 18.124  15.519  7.069  1.00 21.65  ? 226 PHE A CA  1 ? 
ATOM   1597 C C   . PHE A 1 203 ? 18.761  16.875  6.823  1.00 21.93  ? 226 PHE A C   1 ? 
ATOM   1598 O O   . PHE A 1 203 ? 19.637  16.977  5.975  1.00 25.76  ? 226 PHE A O   1 ? 
ATOM   1599 C CB  . PHE A 1 203 ? 18.942  14.782  8.126  1.00 17.55  ? 226 PHE A CB  1 ? 
ATOM   1600 C CG  . PHE A 1 203 ? 18.333  13.508  8.681  1.00 20.65  ? 226 PHE A CG  1 ? 
ATOM   1601 C CD1 . PHE A 1 203 ? 18.485  12.300  8.019  1.00 21.50  ? 226 PHE A CD1 1 ? 
ATOM   1602 C CD2 . PHE A 1 203 ? 17.625  13.526  9.874  1.00 20.76  ? 226 PHE A CD2 1 ? 
ATOM   1603 C CE1 . PHE A 1 203 ? 17.929  11.145  8.531  1.00 21.80  ? 226 PHE A CE1 1 ? 
ATOM   1604 C CE2 . PHE A 1 203 ? 17.072  12.367  10.377 1.00 19.21  ? 226 PHE A CE2 1 ? 
ATOM   1605 C CZ  . PHE A 1 203 ? 17.224  11.182  9.707  1.00 24.72  ? 226 PHE A CZ  1 ? 
ATOM   1606 N N   . THR A 1 204 ? 18.299  17.891  7.534  1.00 20.88  ? 227 THR A N   1 ? 
ATOM   1607 C CA  . THR A 1 204 ? 18.924  19.221  7.459  1.00 24.07  ? 227 THR A CA  1 ? 
ATOM   1608 C C   . THR A 1 204 ? 19.324  19.639  8.866  1.00 25.20  ? 227 THR A C   1 ? 
ATOM   1609 O O   . THR A 1 204 ? 18.432  19.706  9.715  1.00 20.05  ? 227 THR A O   1 ? 
ATOM   1610 C CB  . THR A 1 204 ? 17.995  20.234  6.795  1.00 23.59  ? 227 THR A CB  1 ? 
ATOM   1611 O OG1 . THR A 1 204 ? 17.919  19.868  5.426  1.00 28.18  ? 227 THR A OG1 1 ? 
ATOM   1612 C CG2 . THR A 1 204 ? 18.518  21.650  6.927  1.00 22.42  ? 227 THR A CG2 1 ? 
ATOM   1613 N N   . GLU A 1 205 ? 20.625  19.859  9.100  1.00 22.86  ? 228 GLU A N   1 ? 
ATOM   1614 C CA  . GLU A 1 205 ? 21.131  20.332  10.413 1.00 21.84  ? 228 GLU A CA  1 ? 
ATOM   1615 C C   . GLU A 1 205 ? 20.762  21.811  10.520 1.00 18.79  ? 228 GLU A C   1 ? 
ATOM   1616 O O   . GLU A 1 205 ? 21.517  22.646  10.022 1.00 20.30  ? 228 GLU A O   1 ? 
ATOM   1617 C CB  . GLU A 1 205 ? 22.623  20.085  10.618 1.00 25.10  ? 228 GLU A CB  1 ? 
ATOM   1618 C CG  . GLU A 1 205 ? 23.116  20.445  12.012 1.00 24.10  ? 228 GLU A CG  1 ? 
ATOM   1619 C CD  . GLU A 1 205 ? 24.567  20.055  12.189 1.00 35.59  ? 228 GLU A CD  1 ? 
ATOM   1620 O OE1 . GLU A 1 205 ? 25.256  20.735  12.970 1.00 43.73  ? 228 GLU A OE1 1 ? 
ATOM   1621 O OE2 . GLU A 1 205 ? 25.006  19.088  11.541 1.00 31.18  ? 228 GLU A OE2 1 ? 
ATOM   1622 N N   . SER A 1 206 ? 19.635  22.085  11.146 1.00 20.06  ? 229 SER A N   1 ? 
ATOM   1623 C CA  . SER A 1 206 ? 19.084  23.456  11.185 1.00 17.84  ? 229 SER A CA  1 ? 
ATOM   1624 C C   . SER A 1 206 ? 19.254  24.061  12.583 1.00 17.61  ? 229 SER A C   1 ? 
ATOM   1625 O O   . SER A 1 206 ? 19.250  25.286  12.692 1.00 19.13  ? 229 SER A O   1 ? 
ATOM   1626 C CB  . SER A 1 206 ? 17.631  23.347  10.815 1.00 22.17  ? 229 SER A CB  1 ? 
ATOM   1627 O OG  . SER A 1 206 ? 16.985  22.312  11.540 1.00 20.01  ? 229 SER A OG  1 ? 
ATOM   1628 N N   . ASN A 1 207 ? 19.347  23.205  13.602 1.00 17.49  ? 230 ASN A N   1 ? 
ATOM   1629 C CA  . ASN A 1 207 ? 19.397  23.714  15.002 1.00 19.30  ? 230 ASN A CA  1 ? 
ATOM   1630 C C   . ASN A 1 207 ? 18.314  24.793  15.157 1.00 20.06  ? 230 ASN A C   1 ? 
ATOM   1631 O O   . ASN A 1 207 ? 18.619  25.850  15.726 1.00 21.03  ? 230 ASN A O   1 ? 
ATOM   1632 C CB  . ASN A 1 207 ? 20.812  24.145  15.367 1.00 21.28  ? 230 ASN A CB  1 ? 
ATOM   1633 C CG  . ASN A 1 207 ? 21.832  23.045  15.188 1.00 19.90  ? 230 ASN A CG  1 ? 
ATOM   1634 O OD1 . ASN A 1 207 ? 21.722  21.983  15.803 1.00 20.61  ? 230 ASN A OD1 1 ? 
ATOM   1635 N ND2 . ASN A 1 207 ? 22.839  23.284  14.365 1.00 19.90  ? 230 ASN A ND2 1 ? 
ATOM   1636 N N   . HIS A 1 208 ? 17.088  24.509  14.709 1.00 18.26  ? 231 HIS A N   1 ? 
ATOM   1637 C CA  . HIS A 1 208 ? 15.993  25.516  14.698 1.00 19.83  ? 231 HIS A CA  1 ? 
ATOM   1638 C C   . HIS A 1 208 ? 15.237  25.508  16.027 1.00 17.17  ? 231 HIS A C   1 ? 
ATOM   1639 O O   . HIS A 1 208 ? 14.371  26.340  16.247 1.00 17.75  ? 231 HIS A O   1 ? 
ATOM   1640 C CB  . HIS A 1 208 ? 15.048  25.248  13.528 1.00 16.92  ? 231 HIS A CB  1 ? 
ATOM   1641 C CG  . HIS A 1 208 ? 14.359  23.933  13.620 1.00 17.95  ? 231 HIS A CG  1 ? 
ATOM   1642 N ND1 . HIS A 1 208 ? 14.950  22.746  13.253 1.00 20.72  ? 231 HIS A ND1 1 ? 
ATOM   1643 C CD2 . HIS A 1 208 ? 13.138  23.620  14.051 1.00 16.71  ? 231 HIS A CD2 1 ? 
ATOM   1644 C CE1 . HIS A 1 208 ? 14.096  21.759  13.452 1.00 19.03  ? 231 HIS A CE1 1 ? 
ATOM   1645 N NE2 . HIS A 1 208 ? 12.992  22.268  13.937 1.00 21.55  ? 231 HIS A NE2 1 ? 
ATOM   1646 N N   . GLY A 1 209 ? 15.605  24.570  16.881 1.00 17.73  ? 232 GLY A N   1 ? 
ATOM   1647 C CA  . GLY A 1 209 ? 14.985  24.480  18.200 1.00 15.81  ? 232 GLY A CA  1 ? 
ATOM   1648 C C   . GLY A 1 209 ? 15.697  23.449  19.030 1.00 16.44  ? 232 GLY A C   1 ? 
ATOM   1649 O O   . GLY A 1 209 ? 16.830  23.116  18.701 1.00 18.64  ? 232 GLY A O   1 ? 
ATOM   1650 N N   . LEU A 1 210 ? 15.008  22.938  20.043 1.00 16.69  ? 233 LEU A N   1 ? 
ATOM   1651 C CA  . LEU A 1 210 ? 15.659  21.971  20.946 1.00 19.26  ? 233 LEU A CA  1 ? 
ATOM   1652 C C   . LEU A 1 210 ? 14.680  20.994  21.601 1.00 17.86  ? 233 LEU A C   1 ? 
ATOM   1653 O O   . LEU A 1 210 ? 13.473  21.271  21.614 1.00 18.35  ? 233 LEU A O   1 ? 
ATOM   1654 C CB  . LEU A 1 210 ? 16.405  22.725  22.040 1.00 19.42  ? 233 LEU A CB  1 ? 
ATOM   1655 C CG  . LEU A 1 210 ? 15.587  23.743  22.839 1.00 19.72  ? 233 LEU A CG  1 ? 
ATOM   1656 C CD1 . LEU A 1 210 ? 15.055  23.149  24.128 1.00 15.08  ? 233 LEU A CD1 1 ? 
ATOM   1657 C CD2 . LEU A 1 210 ? 16.461  24.941  23.137 1.00 26.41  ? 233 LEU A CD2 1 ? 
ATOM   1658 N N   . VAL A 1 211 ? 15.224  19.876  22.062 1.00 19.53  ? 234 VAL A N   1 ? 
ATOM   1659 C CA  . VAL A 1 211 ? 14.442  18.934  22.905 1.00 17.39  ? 234 VAL A CA  1 ? 
ATOM   1660 C C   . VAL A 1 211 ? 15.164  18.904  24.268 1.00 19.04  ? 234 VAL A C   1 ? 
ATOM   1661 O O   . VAL A 1 211 ? 16.301  18.465  24.304 1.00 19.59  ? 234 VAL A O   1 ? 
ATOM   1662 C CB  . VAL A 1 211 ? 14.202  17.506  22.381 1.00 18.07  ? 234 VAL A CB  1 ? 
ATOM   1663 C CG1 . VAL A 1 211 ? 13.559  16.621  23.436 1.00 15.19  ? 234 VAL A CG1 1 ? 
ATOM   1664 C CG2 . VAL A 1 211 ? 13.382  17.504  21.100 1.00 16.45  ? 234 VAL A CG2 1 ? 
ATOM   1665 N N   . ASP A 1 212 ? 14.542  19.472  25.295 1.00 19.03  ? 235 ASP A N   1 ? 
ATOM   1666 C CA  . ASP A 1 212 ? 15.053  19.431  26.685 1.00 14.14  ? 235 ASP A CA  1 ? 
ATOM   1667 C C   . ASP A 1 212 ? 13.912  18.904  27.556 1.00 14.61  ? 235 ASP A C   1 ? 
ATOM   1668 O O   . ASP A 1 212 ? 12.761  18.940  27.118 1.00 12.81  ? 235 ASP A O   1 ? 
ATOM   1669 C CB  . ASP A 1 212 ? 15.590  20.771  27.157 1.00 16.66  ? 235 ASP A CB  1 ? 
ATOM   1670 C CG  . ASP A 1 212 ? 17.096  20.968  27.048 1.00 15.90  ? 235 ASP A CG  1 ? 
ATOM   1671 O OD1 . ASP A 1 212 ? 17.715  20.319  26.190 1.00 18.84  ? 235 ASP A OD1 1 ? 
ATOM   1672 O OD2 . ASP A 1 212 ? 17.632  21.771  27.825 1.00 20.32  ? 235 ASP A OD2 1 ? 
ATOM   1673 N N   . TYR A 1 213 ? 14.241  18.482  28.770 1.00 12.45  ? 236 TYR A N   1 ? 
ATOM   1674 C CA  . TYR A 1 213 ? 13.227  17.841  29.627 1.00 11.82  ? 236 TYR A CA  1 ? 
ATOM   1675 C C   . TYR A 1 213 ? 13.120  18.484  30.986 1.00 16.37  ? 236 TYR A C   1 ? 
ATOM   1676 O O   . TYR A 1 213 ? 14.098  19.044  31.476 1.00 17.17  ? 236 TYR A O   1 ? 
ATOM   1677 C CB  . TYR A 1 213 ? 13.704  16.431  29.944 1.00 13.82  ? 236 TYR A CB  1 ? 
ATOM   1678 C CG  . TYR A 1 213 ? 14.034  15.599  28.717 1.00 15.03  ? 236 TYR A CG  1 ? 
ATOM   1679 C CD1 . TYR A 1 213 ? 13.083  15.385  27.731 1.00 13.99  ? 236 TYR A CD1 1 ? 
ATOM   1680 C CD2 . TYR A 1 213 ? 15.293  15.042  28.543 1.00 17.49  ? 236 TYR A CD2 1 ? 
ATOM   1681 C CE1 . TYR A 1 213 ? 13.372  14.637  26.606 1.00 13.46  ? 236 TYR A CE1 1 ? 
ATOM   1682 C CE2 . TYR A 1 213 ? 15.593  14.289  27.421 1.00 17.15  ? 236 TYR A CE2 1 ? 
ATOM   1683 C CZ  . TYR A 1 213 ? 14.627  14.082  26.454 1.00 13.41  ? 236 TYR A CZ  1 ? 
ATOM   1684 O OH  . TYR A 1 213 ? 14.906  13.341  25.349 1.00 13.36  ? 236 TYR A OH  1 ? 
ATOM   1685 N N   . MET A 1 214 ? 11.934  18.380  31.564 1.00 15.45  ? 237 MET A N   1 ? 
ATOM   1686 C CA  . MET A 1 214 ? 11.798  18.803  32.968 1.00 16.06  ? 237 MET A CA  1 ? 
ATOM   1687 C C   . MET A 1 214 ? 11.534  17.531  33.776 1.00 15.90  ? 237 MET A C   1 ? 
ATOM   1688 O O   . MET A 1 214 ? 10.530  16.865  33.523 1.00 12.36  ? 237 MET A O   1 ? 
ATOM   1689 C CB  . MET A 1 214 ? 10.668  19.792  33.259 1.00 15.16  ? 237 MET A CB  1 ? 
ATOM   1690 C CG  . MET A 1 214 ? 10.723  20.320  34.666 1.00 13.19  ? 237 MET A CG  1 ? 
ATOM   1691 S SD  . MET A 1 214 ? 9.326   21.397  35.028 1.00 16.99  ? 237 MET A SD  1 ? 
ATOM   1692 C CE  . MET A 1 214 ? 9.644   22.721  33.857 1.00 13.51  ? 237 MET A CE  1 ? 
ATOM   1693 N N   . VAL A 1 215 ? 12.481  17.203  34.639 1.00 13.85  ? 238 VAL A N   1 ? 
ATOM   1694 C CA  . VAL A 1 215 ? 12.260  16.058  35.550 1.00 15.16  ? 238 VAL A CA  1 ? 
ATOM   1695 C C   . VAL A 1 215 ? 11.149  16.486  36.516 1.00 13.64  ? 238 VAL A C   1 ? 
ATOM   1696 O O   . VAL A 1 215 ? 11.308  17.494  37.185 1.00 14.24  ? 238 VAL A O   1 ? 
ATOM   1697 C CB  . VAL A 1 215 ? 13.532  15.616  36.292 1.00 14.33  ? 238 VAL A CB  1 ? 
ATOM   1698 C CG1 . VAL A 1 215 ? 13.257  14.416  37.186 1.00 13.38  ? 238 VAL A CG1 1 ? 
ATOM   1699 C CG2 . VAL A 1 215 ? 14.654  15.316  35.313 1.00 12.84  ? 238 VAL A CG2 1 ? 
ATOM   1700 N N   . ILE A 1 216 ? 10.083  15.692  36.559 1.00 13.83  ? 239 ILE A N   1 ? 
ATOM   1701 C CA  . ILE A 1 216 ? 8.925   16.085  37.403 1.00 15.69  ? 239 ILE A CA  1 ? 
ATOM   1702 C C   . ILE A 1 216 ? 8.438   14.911  38.260 1.00 16.21  ? 239 ILE A C   1 ? 
ATOM   1703 O O   . ILE A 1 216 ? 8.747   13.766  37.941 1.00 13.59  ? 239 ILE A O   1 ? 
ATOM   1704 C CB  . ILE A 1 216 ? 7.790   16.628  36.523 1.00 15.18  ? 239 ILE A CB  1 ? 
ATOM   1705 C CG1 . ILE A 1 216 ? 7.369   15.576  35.503 1.00 12.33  ? 239 ILE A CG1 1 ? 
ATOM   1706 C CG2 . ILE A 1 216 ? 8.160   17.946  35.853 1.00 11.64  ? 239 ILE A CG2 1 ? 
ATOM   1707 C CD1 . ILE A 1 216 ? 6.088   15.902  34.769 1.00 14.36  ? 239 ILE A CD1 1 ? 
ATOM   1708 N N   . THR A 1 217 ? 7.717   15.252  39.318 1.00 15.99  ? 240 THR A N   1 ? 
ATOM   1709 C CA  . THR A 1 217 ? 7.127   14.233  40.189 1.00 14.14  ? 240 THR A CA  1 ? 
ATOM   1710 C C   . THR A 1 217 ? 5.771   14.729  40.670 1.00 16.63  ? 240 THR A C   1 ? 
ATOM   1711 O O   . THR A 1 217 ? 5.422   15.876  40.380 1.00 18.03  ? 240 THR A O   1 ? 
ATOM   1712 C CB  . THR A 1 217 ? 8.074   13.953  41.358 1.00 15.55  ? 240 THR A CB  1 ? 
ATOM   1713 O OG1 . THR A 1 217 ? 7.524   12.936  42.188 1.00 15.53  ? 240 THR A OG1 1 ? 
ATOM   1714 C CG2 . THR A 1 217 ? 8.296   15.196  42.200 1.00 14.01  ? 240 THR A CG2 1 ? 
ATOM   1715 N N   . ASN A 1 218 ? 5.035   13.870  41.352 1.00 15.75  ? 241 ASN A N   1 ? 
ATOM   1716 C CA  . ASN A 1 218 ? 3.723   14.226  41.940 1.00 17.60  ? 241 ASN A CA  1 ? 
ATOM   1717 C C   . ASN A 1 218 ? 4.001   14.974  43.250 1.00 20.30  ? 241 ASN A C   1 ? 
ATOM   1718 O O   . ASN A 1 218 ? 4.557   14.365  44.159 1.00 21.98  ? 241 ASN A O   1 ? 
ATOM   1719 C CB  . ASN A 1 218 ? 2.892   12.951  42.043 1.00 20.08  ? 241 ASN A CB  1 ? 
ATOM   1720 C CG  . ASN A 1 218 ? 1.569   13.092  42.755 1.00 25.57  ? 241 ASN A CG  1 ? 
ATOM   1721 O OD1 . ASN A 1 218 ? 1.516   13.536  43.904 1.00 29.68  ? 241 ASN A OD1 1 ? 
ATOM   1722 N ND2 . ASN A 1 218 ? 0.499   12.668  42.105 1.00 19.65  ? 241 ASN A ND2 1 ? 
ATOM   1723 N N   . ALA A 1 219 ? 3.632   16.245  43.324 1.00 19.70  ? 242 ALA A N   1 ? 
ATOM   1724 C CA  . ALA A 1 219 ? 3.929   17.092  44.504 1.00 23.00  ? 242 ALA A CA  1 ? 
ATOM   1725 C C   . ALA A 1 219 ? 3.510   16.427  45.826 1.00 26.82  ? 242 ALA A C   1 ? 
ATOM   1726 O O   . ALA A 1 219 ? 4.226   16.576  46.816 1.00 22.63  ? 242 ALA A O   1 ? 
ATOM   1727 C CB  . ALA A 1 219 ? 3.304   18.450  44.323 1.00 22.15  ? 242 ALA A CB  1 ? 
ATOM   1728 N N   . LYS A 1 220 ? 2.411   15.688  45.813 1.00 26.16  ? 243 LYS A N   1 ? 
ATOM   1729 C CA  . LYS A 1 220 ? 1.924   15.031  47.048 1.00 30.39  ? 243 LYS A CA  1 ? 
ATOM   1730 C C   . LYS A 1 220 ? 2.880   13.891  47.436 1.00 30.34  ? 243 LYS A C   1 ? 
ATOM   1731 O O   . LYS A 1 220 ? 3.244   13.817  48.614 1.00 29.34  ? 243 LYS A O   1 ? 
ATOM   1732 C CB  . LYS A 1 220 ? 0.493   14.527  46.857 1.00 28.08  ? 243 LYS A CB  1 ? 
ATOM   1733 C CG  . LYS A 1 220 ? -0.021  13.505  47.848 1.00 36.41  ? 243 LYS A CG  1 ? 
ATOM   1734 C CD  . LYS A 1 220 ? -1.532  13.330  47.767 1.00 38.03  ? 243 LYS A CD  1 ? 
ATOM   1735 C CE  . LYS A 1 220 ? -2.046  12.460  48.866 1.00 48.43  ? 243 LYS A CE  1 ? 
ATOM   1736 N NZ  . LYS A 1 220 ? -1.281  11.216  48.961 1.00 52.50  ? 243 LYS A NZ  1 ? 
ATOM   1737 N N   . PHE A 1 221 ? 3.272   13.056  46.471 1.00 24.46  ? 244 PHE A N   1 ? 
ATOM   1738 C CA  . PHE A 1 221 ? 4.227   11.948  46.747 1.00 25.97  ? 244 PHE A CA  1 ? 
ATOM   1739 C C   . PHE A 1 221 ? 5.545   12.508  47.279 1.00 21.81  ? 244 PHE A C   1 ? 
ATOM   1740 O O   . PHE A 1 221 ? 6.028   12.072  48.326 1.00 22.31  ? 244 PHE A O   1 ? 
ATOM   1741 C CB  . PHE A 1 221 ? 4.473   11.106  45.491 1.00 24.03  ? 244 PHE A CB  1 ? 
ATOM   1742 C CG  . PHE A 1 221 ? 5.681   10.188  45.572 1.00 22.37  ? 244 PHE A CG  1 ? 
ATOM   1743 C CD1 . PHE A 1 221 ? 5.605   8.979   46.248 1.00 25.53  ? 244 PHE A CD1 1 ? 
ATOM   1744 C CD2 . PHE A 1 221 ? 6.888   10.544  44.985 1.00 19.96  ? 244 PHE A CD2 1 ? 
ATOM   1745 C CE1 . PHE A 1 221 ? 6.706   8.147   46.322 1.00 23.27  ? 244 PHE A CE1 1 ? 
ATOM   1746 C CE2 . PHE A 1 221 ? 7.986   9.712   45.071 1.00 19.36  ? 244 PHE A CE2 1 ? 
ATOM   1747 C CZ  . PHE A 1 221 ? 7.893   8.518   45.739 1.00 22.70  ? 244 PHE A CZ  1 ? 
ATOM   1748 N N   . TRP A 1 222 ? 6.079   13.493  46.573 1.00 21.39  ? 245 TRP A N   1 ? 
ATOM   1749 C CA  . TRP A 1 222 ? 7.404   14.034  46.922 1.00 18.87  ? 245 TRP A CA  1 ? 
ATOM   1750 C C   . TRP A 1 222 ? 7.358   14.758  48.260 1.00 24.23  ? 245 TRP A C   1 ? 
ATOM   1751 O O   . TRP A 1 222 ? 8.265   14.587  49.068 1.00 25.89  ? 245 TRP A O   1 ? 
ATOM   1752 C CB  . TRP A 1 222 ? 7.852   14.978  45.800 1.00 16.33  ? 245 TRP A CB  1 ? 
ATOM   1753 C CG  . TRP A 1 222 ? 9.334   15.219  45.763 1.00 18.47  ? 245 TRP A CG  1 ? 
ATOM   1754 C CD1 . TRP A 1 222 ? 9.996   16.337  46.167 1.00 18.44  ? 245 TRP A CD1 1 ? 
ATOM   1755 C CD2 . TRP A 1 222 ? 10.342  14.303  45.288 1.00 18.00  ? 245 TRP A CD2 1 ? 
ATOM   1756 N NE1 . TRP A 1 222 ? 11.342  16.181  45.984 1.00 19.46  ? 245 TRP A NE1 1 ? 
ATOM   1757 C CE2 . TRP A 1 222 ? 11.585  14.948  45.445 1.00 18.83  ? 245 TRP A CE2 1 ? 
ATOM   1758 C CE3 . TRP A 1 222 ? 10.314  13.014  44.749 1.00 23.57  ? 245 TRP A CE3 1 ? 
ATOM   1759 C CZ2 . TRP A 1 222 ? 12.785  14.345  45.081 1.00 18.77  ? 245 TRP A CZ2 1 ? 
ATOM   1760 C CZ3 . TRP A 1 222 ? 11.501  12.424  44.384 1.00 20.37  ? 245 TRP A CZ3 1 ? 
ATOM   1761 C CH2 . TRP A 1 222 ? 12.717  13.079  44.551 1.00 19.03  ? 245 TRP A CH2 1 ? 
ATOM   1762 N N   . ASN A 1 223 ? 6.309   15.538  48.467 1.00 26.74  ? 246 ASN A N   1 ? 
ATOM   1763 C CA  . ASN A 1 223 ? 6.223   16.348  49.706 1.00 28.27  ? 246 ASN A CA  1 ? 
ATOM   1764 C C   . ASN A 1 223 ? 5.885   15.435  50.883 1.00 27.26  ? 246 ASN A C   1 ? 
ATOM   1765 O O   . ASN A 1 223 ? 6.082   15.856  52.023 1.00 33.93  ? 246 ASN A O   1 ? 
ATOM   1766 C CB  . ASN A 1 223 ? 5.265   17.514  49.515 1.00 34.66  ? 246 ASN A CB  1 ? 
ATOM   1767 C CG  . ASN A 1 223 ? 5.875   18.609  48.679 1.00 32.39  ? 246 ASN A CG  1 ? 
ATOM   1768 O OD1 . ASN A 1 223 ? 7.101   18.683  48.552 1.00 50.48  ? 246 ASN A OD1 1 ? 
ATOM   1769 N ND2 . ASN A 1 223 ? 5.043   19.461  48.104 1.00 40.68  ? 246 ASN A ND2 1 ? 
ATOM   1770 N N   . GLY A 1 224 ? 5.458   14.215  50.596 1.00 28.70  ? 247 GLY A N   1 ? 
ATOM   1771 C CA  . GLY A 1 224 ? 5.081   13.271  51.654 1.00 28.82  ? 247 GLY A CA  1 ? 
ATOM   1772 C C   . GLY A 1 224 ? 6.246   12.396  52.044 1.00 34.58  ? 247 GLY A C   1 ? 
ATOM   1773 O O   . GLY A 1 224 ? 6.111   11.617  52.996 1.00 27.90  ? 247 GLY A O   1 ? 
ATOM   1774 N N   . LEU A 1 225 ? 7.350   12.512  51.310 1.00 27.97  ? 248 LEU A N   1 ? 
ATOM   1775 C CA  . LEU A 1 225 ? 8.556   11.711  51.615 1.00 22.34  ? 248 LEU A CA  1 ? 
ATOM   1776 C C   . LEU A 1 225 ? 9.182   12.169  52.938 1.00 20.08  ? 248 LEU A C   1 ? 
ATOM   1777 O O   . LEU A 1 225 ? 9.018   13.336  53.313 1.00 21.36  ? 248 LEU A O   1 ? 
ATOM   1778 C CB  . LEU A 1 225 ? 9.562   11.870  50.475 1.00 20.58  ? 248 LEU A CB  1 ? 
ATOM   1779 C CG  . LEU A 1 225 ? 9.240   11.216  49.130 1.00 20.57  ? 248 LEU A CG  1 ? 
ATOM   1780 C CD1 . LEU A 1 225 ? 10.300  11.599  48.118 1.00 17.03  ? 248 LEU A CD1 1 ? 
ATOM   1781 C CD2 . LEU A 1 225 ? 9.155   9.714   49.250 1.00 20.31  ? 248 LEU A CD2 1 ? 
ATOM   1782 N N   . PRO A 1 226 ? 9.878   11.282  53.669 1.00 20.29  ? 249 PRO A N   1 ? 
ATOM   1783 C CA  . PRO A 1 226 ? 10.656  11.729  54.812 1.00 23.81  ? 249 PRO A CA  1 ? 
ATOM   1784 C C   . PRO A 1 226 ? 11.661  12.776  54.306 1.00 25.70  ? 249 PRO A C   1 ? 
ATOM   1785 O O   . PRO A 1 226 ? 12.240  12.589  53.232 1.00 22.75  ? 249 PRO A O   1 ? 
ATOM   1786 C CB  . PRO A 1 226 ? 11.318  10.444  55.280 1.00 23.80  ? 249 PRO A CB  1 ? 
ATOM   1787 C CG  . PRO A 1 226 ? 10.412  9.352   54.781 1.00 24.01  ? 249 PRO A CG  1 ? 
ATOM   1788 C CD  . PRO A 1 226 ? 9.897   9.857   53.452 1.00 22.27  ? 249 PRO A CD  1 ? 
ATOM   1789 N N   . ALA A 1 227 ? 11.848  13.861  55.055 1.00 19.69  ? 250 ALA A N   1 ? 
ATOM   1790 C CA  . ALA A 1 227 ? 12.737  14.962  54.613 1.00 17.89  ? 250 ALA A CA  1 ? 
ATOM   1791 C C   . ALA A 1 227 ? 14.140  14.470  54.247 1.00 17.36  ? 250 ALA A C   1 ? 
ATOM   1792 O O   . ALA A 1 227 ? 14.677  14.899  53.230 1.00 19.49  ? 250 ALA A O   1 ? 
ATOM   1793 C CB  . ALA A 1 227 ? 12.790  16.052  55.658 1.00 18.69  ? 250 ALA A CB  1 ? 
ATOM   1794 N N   . ASP A 1 228 ? 14.720  13.615  55.076 1.00 16.71  ? 251 ASP A N   1 ? 
ATOM   1795 C CA  . ASP A 1 228 ? 16.106  13.159  54.827 1.00 19.71  ? 251 ASP A CA  1 ? 
ATOM   1796 C C   . ASP A 1 228 ? 16.157  12.442  53.478 1.00 19.78  ? 251 ASP A C   1 ? 
ATOM   1797 O O   . ASP A 1 228 ? 17.064  12.709  52.701 1.00 23.36  ? 251 ASP A O   1 ? 
ATOM   1798 C CB  . ASP A 1 228 ? 16.585  12.298  55.976 1.00 21.46  ? 251 ASP A CB  1 ? 
ATOM   1799 C CG  . ASP A 1 228 ? 15.752  11.067  56.299 1.00 28.07  ? 251 ASP A CG  1 ? 
ATOM   1800 O OD1 . ASP A 1 228 ? 14.522  11.135  56.161 1.00 38.33  ? 251 ASP A OD1 1 ? 
ATOM   1801 O OD2 . ASP A 1 228 ? 16.346  10.052  56.698 1.00 38.62  ? 251 ASP A OD2 1 ? 
ATOM   1802 N N   . ILE A 1 229 ? 15.182  11.574  53.231 1.00 20.25  ? 252 ILE A N   1 ? 
ATOM   1803 C CA  . ILE A 1 229 ? 15.114  10.822  51.946 1.00 20.29  ? 252 ILE A CA  1 ? 
ATOM   1804 C C   . ILE A 1 229 ? 14.946  11.800  50.768 1.00 21.59  ? 252 ILE A C   1 ? 
ATOM   1805 O O   . ILE A 1 229 ? 15.678  11.679  49.796 1.00 18.13  ? 252 ILE A O   1 ? 
ATOM   1806 C CB  . ILE A 1 229 ? 13.992  9.774   52.022 1.00 23.48  ? 252 ILE A CB  1 ? 
ATOM   1807 C CG1 . ILE A 1 229 ? 14.332  8.696   53.044 1.00 17.39  ? 252 ILE A CG1 1 ? 
ATOM   1808 C CG2 . ILE A 1 229 ? 13.680  9.189   50.648 1.00 23.09  ? 252 ILE A CG2 1 ? 
ATOM   1809 C CD1 . ILE A 1 229 ? 13.507  7.432   52.916 1.00 24.37  ? 252 ILE A CD1 1 ? 
ATOM   1810 N N   . ARG A 1 230 ? 13.992  12.718  50.883 1.00 19.12  ? 253 ARG A N   1 ? 
ATOM   1811 C CA  . ARG A 1 230 ? 13.733  13.680  49.785 1.00 18.76  ? 253 ARG A CA  1 ? 
ATOM   1812 C C   . ARG A 1 230 ? 15.029  14.431  49.448 1.00 22.66  ? 253 ARG A C   1 ? 
ATOM   1813 O O   . ARG A 1 230 ? 15.407  14.497  48.284 1.00 19.49  ? 253 ARG A O   1 ? 
ATOM   1814 C CB  . ARG A 1 230 ? 12.635  14.672  50.162 1.00 19.54  ? 253 ARG A CB  1 ? 
ATOM   1815 C CG  . ARG A 1 230 ? 12.478  15.822  49.181 1.00 22.73  ? 253 ARG A CG  1 ? 
ATOM   1816 C CD  . ARG A 1 230 ? 11.255  16.656  49.485 1.00 26.38  ? 253 ARG A CD  1 ? 
ATOM   1817 N NE  . ARG A 1 230 ? 11.352  17.270  50.811 1.00 37.80  ? 253 ARG A NE  1 ? 
ATOM   1818 C CZ  . ARG A 1 230 ? 10.602  16.933  51.848 1.00 44.62  ? 253 ARG A CZ  1 ? 
ATOM   1819 N NH1 . ARG A 1 230 ? 9.717   15.957  51.739 1.00 38.57  ? 253 ARG A NH1 1 ? 
ATOM   1820 N NH2 . ARG A 1 230 ? 10.740  17.578  52.990 1.00 39.30  ? 253 ARG A NH2 1 ? 
ATOM   1821 N N   . GLU A 1 231 ? 15.673  14.984  50.465 1.00 24.02  ? 254 GLU A N   1 ? 
ATOM   1822 C CA  . GLU A 1 231 ? 16.887  15.791  50.210 1.00 22.80  ? 254 GLU A CA  1 ? 
ATOM   1823 C C   . GLU A 1 231 ? 17.975  14.905  49.578 1.00 22.09  ? 254 GLU A C   1 ? 
ATOM   1824 O O   . GLU A 1 231 ? 18.643  15.353  48.654 1.00 22.49  ? 254 GLU A O   1 ? 
ATOM   1825 C CB  . GLU A 1 231 ? 17.349  16.438  51.509 1.00 25.31  ? 254 GLU A CB  1 ? 
ATOM   1826 C CG  . GLU A 1 231 ? 16.336  17.428  52.067 1.00 34.06  ? 254 GLU A CG  1 ? 
ATOM   1827 C CD  . GLU A 1 231 ? 16.944  18.347  53.104 1.00 43.15  ? 254 GLU A CD  1 ? 
ATOM   1828 O OE1 . GLU A 1 231 ? 16.688  19.562  53.015 1.00 40.25  ? 254 GLU A OE1 1 ? 
ATOM   1829 O OE2 . GLU A 1 231 ? 17.679  17.851  53.984 1.00 41.68  ? 254 GLU A OE2 1 ? 
ATOM   1830 N N   . GLU A 1 232 ? 18.095  13.675  50.051 1.00 18.82  ? 255 GLU A N   1 ? 
ATOM   1831 C CA  . GLU A 1 232 ? 19.108  12.756  49.480 1.00 17.64  ? 255 GLU A CA  1 ? 
ATOM   1832 C C   . GLU A 1 232 ? 18.772  12.481  48.006 1.00 16.57  ? 255 GLU A C   1 ? 
ATOM   1833 O O   . GLU A 1 232 ? 19.674  12.510  47.179 1.00 19.14  ? 255 GLU A O   1 ? 
ATOM   1834 C CB  . GLU A 1 232 ? 19.188  11.445  50.247 1.00 15.60  ? 255 GLU A CB  1 ? 
ATOM   1835 C CG  . GLU A 1 232 ? 20.168  10.440  49.650 1.00 25.00  ? 255 GLU A CG  1 ? 
ATOM   1836 C CD  . GLU A 1 232 ? 21.645  10.744  49.817 1.00 28.10  ? 255 GLU A CD  1 ? 
ATOM   1837 O OE1 . GLU A 1 232 ? 22.467  10.004  49.248 1.00 30.80  ? 255 GLU A OE1 1 ? 
ATOM   1838 O OE2 . GLU A 1 232 ? 21.979  11.715  50.518 1.00 35.11  ? 255 GLU A OE2 1 ? 
ATOM   1839 N N   . LEU A 1 233 ? 17.508  12.212  47.725 1.00 15.92  ? 256 LEU A N   1 ? 
ATOM   1840 C CA  . LEU A 1 233 ? 17.086  11.937  46.331 1.00 13.74  ? 256 LEU A CA  1 ? 
ATOM   1841 C C   . LEU A 1 233 ? 17.373  13.170  45.460 1.00 16.23  ? 256 LEU A C   1 ? 
ATOM   1842 O O   . LEU A 1 233 ? 17.818  13.004  44.335 1.00 15.78  ? 256 LEU A O   1 ? 
ATOM   1843 C CB  . LEU A 1 233 ? 15.609  11.560  46.319 1.00 15.34  ? 256 LEU A CB  1 ? 
ATOM   1844 C CG  . LEU A 1 233 ? 15.235  10.211  46.933 1.00 14.74  ? 256 LEU A CG  1 ? 
ATOM   1845 C CD1 . LEU A 1 233 ? 13.728  10.105  46.961 1.00 15.89  ? 256 LEU A CD1 1 ? 
ATOM   1846 C CD2 . LEU A 1 233 ? 15.818  9.109   46.086 1.00 15.07  ? 256 LEU A CD2 1 ? 
ATOM   1847 N N   . GLN A 1 234 ? 17.133  14.357  46.012 1.00 14.32  ? 257 GLN A N   1 ? 
ATOM   1848 C CA  . GLN A 1 234 ? 17.413  15.608  45.267 1.00 16.45  ? 257 GLN A CA  1 ? 
ATOM   1849 C C   . GLN A 1 234 ? 18.918  15.731  44.972 1.00 17.17  ? 257 GLN A C   1 ? 
ATOM   1850 O O   . GLN A 1 234 ? 19.268  16.135  43.860 1.00 20.07  ? 257 GLN A O   1 ? 
ATOM   1851 C CB  . GLN A 1 234 ? 16.937  16.860  45.998 1.00 16.92  ? 257 GLN A CB  1 ? 
ATOM   1852 C CG  . GLN A 1 234 ? 17.000  18.118  45.139 1.00 20.49  ? 257 GLN A CG  1 ? 
ATOM   1853 C CD  . GLN A 1 234 ? 16.244  17.987  43.835 1.00 22.46  ? 257 GLN A CD  1 ? 
ATOM   1854 O OE1 . GLN A 1 234 ? 15.048  17.687  43.816 1.00 24.82  ? 257 GLN A OE1 1 ? 
ATOM   1855 N NE2 . GLN A 1 234 ? 16.937  18.197  42.727 1.00 22.34  ? 257 GLN A NE2 1 ? 
ATOM   1856 N N   . ARG A 1 235 ? 19.761  15.429  45.958 1.00 17.32  ? 258 ARG A N   1 ? 
ATOM   1857 C CA  . ARG A 1 235 ? 21.230  15.490  45.762 1.00 15.16  ? 258 ARG A CA  1 ? 
ATOM   1858 C C   . ARG A 1 235 ? 21.641  14.512  44.646 1.00 16.38  ? 258 ARG A C   1 ? 
ATOM   1859 O O   . ARG A 1 235 ? 22.409  14.881  43.757 1.00 19.16  ? 258 ARG A O   1 ? 
ATOM   1860 C CB  . ARG A 1 235 ? 21.856  15.196  47.124 1.00 19.01  ? 258 ARG A CB  1 ? 
ATOM   1861 C CG  . ARG A 1 235 ? 21.794  16.377  48.079 1.00 24.10  ? 258 ARG A CG  1 ? 
ATOM   1862 C CD  . ARG A 1 235 ? 22.812  16.251  49.193 1.00 25.61  ? 258 ARG A CD  1 ? 
ATOM   1863 N NE  . ARG A 1 235 ? 22.523  15.116  50.073 1.00 29.51  ? 258 ARG A NE  1 ? 
ATOM   1864 C CZ  . ARG A 1 235 ? 21.756  15.180  51.149 1.00 34.02  ? 258 ARG A CZ  1 ? 
ATOM   1865 N NH1 . ARG A 1 235 ? 21.234  16.333  51.523 1.00 32.66  ? 258 ARG A NH1 1 ? 
ATOM   1866 N NH2 . ARG A 1 235 ? 21.519  14.091  51.852 1.00 27.88  ? 258 ARG A NH2 1 ? 
ATOM   1867 N N   . ILE A 1 236 ? 21.100  13.307  44.693 1.00 16.93  ? 259 ILE A N   1 ? 
ATOM   1868 C CA  . ILE A 1 236 ? 21.381  12.286  43.652 1.00 14.68  ? 259 ILE A CA  1 ? 
ATOM   1869 C C   . ILE A 1 236 ? 20.905  12.808  42.291 1.00 14.28  ? 259 ILE A C   1 ? 
ATOM   1870 O O   . ILE A 1 236 ? 21.658  12.714  41.330 1.00 14.89  ? 259 ILE A O   1 ? 
ATOM   1871 C CB  . ILE A 1 236 ? 20.713  10.964  44.065 1.00 15.80  ? 259 ILE A CB  1 ? 
ATOM   1872 C CG1 . ILE A 1 236 ? 21.309  10.452  45.378 1.00 19.41  ? 259 ILE A CG1 1 ? 
ATOM   1873 C CG2 . ILE A 1 236 ? 20.787  9.919   42.956 1.00 14.05  ? 259 ILE A CG2 1 ? 
ATOM   1874 C CD1 . ILE A 1 236 ? 20.604  9.245   45.968 1.00 16.55  ? 259 ILE A CD1 1 ? 
ATOM   1875 N N   . MET A 1 237 ? 19.700  13.354  42.255 1.00 15.27  ? 260 MET A N   1 ? 
ATOM   1876 C CA  . MET A 1 237 ? 19.148  13.916  41.003 1.00 15.24  ? 260 MET A CA  1 ? 
ATOM   1877 C C   . MET A 1 237 ? 20.118  14.978  40.461 1.00 14.42  ? 260 MET A C   1 ? 
ATOM   1878 O O   . MET A 1 237 ? 20.372  14.995  39.268 1.00 15.68  ? 260 MET A O   1 ? 
ATOM   1879 C CB  . MET A 1 237 ? 17.757  14.506  41.262 1.00 14.49  ? 260 MET A CB  1 ? 
ATOM   1880 C CG  . MET A 1 237 ? 17.087  15.096  40.034 1.00 17.10  ? 260 MET A CG  1 ? 
ATOM   1881 S SD  . MET A 1 237 ? 16.998  13.944  38.649 1.00 18.55  ? 260 MET A SD  1 ? 
ATOM   1882 C CE  . MET A 1 237 ? 15.836  12.746  39.314 1.00 15.88  ? 260 MET A CE  1 ? 
ATOM   1883 N N   . ASP A 1 238 ? 20.609  15.841  41.343 1.00 19.77  ? 261 ASP A N   1 ? 
ATOM   1884 C CA  . ASP A 1 238 ? 21.603  16.875  40.946 1.00 17.89  ? 261 ASP A CA  1 ? 
ATOM   1885 C C   . ASP A 1 238 ? 22.837  16.228  40.301 1.00 16.67  ? 261 ASP A C   1 ? 
ATOM   1886 O O   . ASP A 1 238 ? 23.292  16.721  39.279 1.00 19.52  ? 261 ASP A O   1 ? 
ATOM   1887 C CB  . ASP A 1 238 ? 21.954  17.740  42.138 1.00 19.38  ? 261 ASP A CB  1 ? 
ATOM   1888 C CG  . ASP A 1 238 ? 20.793  18.549  42.695 1.00 22.27  ? 261 ASP A CG  1 ? 
ATOM   1889 O OD1 . ASP A 1 238 ? 19.816  18.749  41.953 1.00 26.15  ? 261 ASP A OD1 1 ? 
ATOM   1890 O OD2 . ASP A 1 238 ? 20.871  18.953  43.869 1.00 29.64  ? 261 ASP A OD2 1 ? 
ATOM   1891 N N   . GLU A 1 239 ? 23.333  15.154  40.892 1.00 15.76  ? 262 GLU A N   1 ? 
ATOM   1892 C CA  . GLU A 1 239 ? 24.488  14.440  40.295 1.00 18.59  ? 262 GLU A CA  1 ? 
ATOM   1893 C C   . GLU A 1 239 ? 24.085  13.827  38.944 1.00 16.85  ? 262 GLU A C   1 ? 
ATOM   1894 O O   . GLU A 1 239 ? 24.900  13.868  38.016 1.00 17.17  ? 262 GLU A O   1 ? 
ATOM   1895 C CB  . GLU A 1 239 ? 25.029  13.346  41.205 1.00 22.67  ? 262 GLU A CB  1 ? 
ATOM   1896 C CG  . GLU A 1 239 ? 25.704  13.900  42.452 1.00 24.75  ? 262 GLU A CG  1 ? 
ATOM   1897 C CD  . GLU A 1 239 ? 26.348  12.821  43.296 1.00 22.88  ? 262 GLU A CD  1 ? 
ATOM   1898 O OE1 . GLU A 1 239 ? 26.938  11.887  42.729 1.00 19.14  ? 262 GLU A OE1 1 ? 
ATOM   1899 O OE2 . GLU A 1 239 ? 26.250  12.925  44.528 1.00 27.12  ? 262 GLU A OE2 1 ? 
ATOM   1900 N N   . VAL A 1 240 ? 22.885  13.255  38.871 1.00 13.75  ? 263 VAL A N   1 ? 
ATOM   1901 C CA  . VAL A 1 240 ? 22.438  12.592  37.605 1.00 12.26  ? 263 VAL A CA  1 ? 
ATOM   1902 C C   . VAL A 1 240 ? 22.296  13.658  36.500 1.00 14.14  ? 263 VAL A C   1 ? 
ATOM   1903 O O   . VAL A 1 240 ? 22.671  13.397  35.355 1.00 14.56  ? 263 VAL A O   1 ? 
ATOM   1904 C CB  . VAL A 1 240 ? 21.149  11.760  37.755 1.00 14.30  ? 263 VAL A CB  1 ? 
ATOM   1905 C CG1 . VAL A 1 240 ? 20.693  11.149  36.440 1.00 12.97  ? 263 VAL A CG1 1 ? 
ATOM   1906 C CG2 . VAL A 1 240 ? 21.292  10.680  38.819 1.00 15.35  ? 263 VAL A CG2 1 ? 
ATOM   1907 N N   . THR A 1 241 ? 21.771  14.815  36.858 1.00 12.27  ? 264 THR A N   1 ? 
ATOM   1908 C CA  . THR A 1 241 ? 21.589  15.899  35.882 1.00 15.37  ? 264 THR A CA  1 ? 
ATOM   1909 C C   . THR A 1 241 ? 22.909  16.214  35.193 1.00 14.67  ? 264 THR A C   1 ? 
ATOM   1910 O O   . THR A 1 241 ? 22.931  16.274  33.963 1.00 14.86  ? 264 THR A O   1 ? 
ATOM   1911 C CB  . THR A 1 241 ? 20.970  17.072  36.641 1.00 13.57  ? 264 THR A CB  1 ? 
ATOM   1912 O OG1 . THR A 1 241 ? 19.674  16.638  37.031 1.00 13.46  ? 264 THR A OG1 1 ? 
ATOM   1913 C CG2 . THR A 1 241 ? 20.885  18.326  35.789 1.00 13.17  ? 264 THR A CG2 1 ? 
ATOM   1914 N N   . VAL A 1 242 ? 23.983  16.363  35.971 1.00 16.88  ? 265 VAL A N   1 ? 
ATOM   1915 C CA  . VAL A 1 242 ? 25.335  16.652  35.394 1.00 15.07  ? 265 VAL A CA  1 ? 
ATOM   1916 C C   . VAL A 1 242 ? 25.688  15.546  34.386 1.00 13.07  ? 265 VAL A C   1 ? 
ATOM   1917 O O   . VAL A 1 242 ? 26.072  15.854  33.272 1.00 17.76  ? 265 VAL A O   1 ? 
ATOM   1918 C CB  . VAL A 1 242 ? 26.390  16.774  36.513 1.00 16.99  ? 265 VAL A CB  1 ? 
ATOM   1919 C CG1 . VAL A 1 242 ? 27.810  16.727  35.967 1.00 17.15  ? 265 VAL A CG1 1 ? 
ATOM   1920 C CG2 . VAL A 1 242 ? 26.167  18.006  37.374 1.00 18.78  ? 265 VAL A CG2 1 ? 
ATOM   1921 N N   . GLN A 1 243 ? 25.481  14.300  34.778 1.00 14.83  ? 266 GLN A N   1 ? 
ATOM   1922 C CA  . GLN A 1 243 ? 25.857  13.172  33.899 1.00 15.41  ? 266 GLN A CA  1 ? 
ATOM   1923 C C   . GLN A 1 243 ? 25.063  13.200  32.586 1.00 16.57  ? 266 GLN A C   1 ? 
ATOM   1924 O O   . GLN A 1 243 ? 25.662  13.003  31.534 1.00 18.08  ? 266 GLN A O   1 ? 
ATOM   1925 C CB  . GLN A 1 243 ? 25.565  11.890  34.663 1.00 15.32  ? 266 GLN A CB  1 ? 
ATOM   1926 C CG  . GLN A 1 243 ? 26.413  11.728  35.920 1.00 20.60  ? 266 GLN A CG  1 ? 
ATOM   1927 C CD  . GLN A 1 243 ? 27.871  11.452  35.626 1.00 16.01  ? 266 GLN A CD  1 ? 
ATOM   1928 O OE1 . GLN A 1 243 ? 28.213  10.618  34.784 1.00 17.44  ? 266 GLN A OE1 1 ? 
ATOM   1929 N NE2 . GLN A 1 243 ? 28.745  12.154  36.327 1.00 16.42  ? 266 GLN A NE2 1 ? 
ATOM   1930 N N   . VAL A 1 244 ? 23.748  13.393  32.684 1.00 17.16  ? 267 VAL A N   1 ? 
ATOM   1931 C CA  . VAL A 1 244 ? 22.884  13.446  31.474 1.00 15.22  ? 267 VAL A CA  1 ? 
ATOM   1932 C C   . VAL A 1 244 ? 23.393  14.572  30.577 1.00 14.51  ? 267 VAL A C   1 ? 
ATOM   1933 O O   . VAL A 1 244 ? 23.574  14.355  29.385 1.00 16.02  ? 267 VAL A O   1 ? 
ATOM   1934 C CB  . VAL A 1 244 ? 21.407  13.690  31.849 1.00 13.42  ? 267 VAL A CB  1 ? 
ATOM   1935 C CG1 . VAL A 1 244 ? 20.537  13.968  30.634 1.00 14.21  ? 267 VAL A CG1 1 ? 
ATOM   1936 C CG2 . VAL A 1 244 ? 20.847  12.526  32.653 1.00 12.27  ? 267 VAL A CG2 1 ? 
ATOM   1937 N N   . ASN A 1 245 ? 23.590  15.735  31.178 1.00 16.52  ? 268 ASN A N   1 ? 
ATOM   1938 C CA  . ASN A 1 245 ? 23.954  16.934  30.384 1.00 16.66  ? 268 ASN A CA  1 ? 
ATOM   1939 C C   . ASN A 1 245 ? 25.268  16.716  29.635 1.00 21.96  ? 268 ASN A C   1 ? 
ATOM   1940 O O   . ASN A 1 245 ? 25.431  17.265  28.549 1.00 23.09  ? 268 ASN A O   1 ? 
ATOM   1941 C CB  . ASN A 1 245 ? 23.962  18.140  31.303 1.00 17.32  ? 268 ASN A CB  1 ? 
ATOM   1942 C CG  . ASN A 1 245 ? 22.562  18.556  31.686 1.00 22.58  ? 268 ASN A CG  1 ? 
ATOM   1943 O OD1 . ASN A 1 245 ? 21.584  18.010  31.167 1.00 17.53  ? 268 ASN A OD1 1 ? 
ATOM   1944 N ND2 . ASN A 1 245 ? 22.448  19.527  32.576 1.00 22.09  ? 268 ASN A ND2 1 ? 
ATOM   1945 N N   . LEU A 1 246 ? 26.176  15.960  30.233 1.00 23.67  ? 269 LEU A N   1 ? 
ATOM   1946 C CA  . LEU A 1 246 ? 27.485  15.698  29.598 1.00 22.98  ? 269 LEU A CA  1 ? 
ATOM   1947 C C   . LEU A 1 246 ? 27.313  14.635  28.510 1.00 27.83  ? 269 LEU A C   1 ? 
ATOM   1948 O O   . LEU A 1 246 ? 27.838  14.814  27.417 1.00 33.21  ? 269 LEU A O   1 ? 
ATOM   1949 C CB  . LEU A 1 246 ? 28.430  15.251  30.707 1.00 27.53  ? 269 LEU A CB  1 ? 
ATOM   1950 C CG  . LEU A 1 246 ? 28.909  16.341  31.666 1.00 22.98  ? 269 LEU A CG  1 ? 
ATOM   1951 C CD1 . LEU A 1 246 ? 29.725  15.735  32.790 1.00 21.86  ? 269 LEU A CD1 1 ? 
ATOM   1952 C CD2 . LEU A 1 246 ? 29.716  17.377  30.916 1.00 18.79  ? 269 LEU A CD2 1 ? 
ATOM   1953 N N   . GLU A 1 247 ? 26.590  13.569  28.821 1.00 23.91  ? 270 GLU A N   1 ? 
ATOM   1954 C CA  . GLU A 1 247 ? 26.423  12.475  27.844 1.00 25.15  ? 270 GLU A CA  1 ? 
ATOM   1955 C C   . GLU A 1 247 ? 25.591  12.960  26.651 1.00 27.78  ? 270 GLU A C   1 ? 
ATOM   1956 O O   . GLU A 1 247 ? 25.829  12.490  25.544 1.00 27.64  ? 270 GLU A O   1 ? 
ATOM   1957 C CB  . GLU A 1 247 ? 25.773  11.270  28.516 1.00 30.62  ? 270 GLU A CB  1 ? 
ATOM   1958 C CG  . GLU A 1 247 ? 26.483  9.967   28.172 1.00 44.58  ? 270 GLU A CG  1 ? 
ATOM   1959 C CD  . GLU A 1 247 ? 25.797  8.704   28.642 1.00 58.11  ? 270 GLU A CD  1 ? 
ATOM   1960 O OE1 . GLU A 1 247 ? 25.204  8.722   29.736 1.00 51.35  ? 270 GLU A OE1 1 ? 
ATOM   1961 O OE2 . GLU A 1 247 ? 25.866  7.702   27.900 1.00 78.59  ? 270 GLU A OE2 1 ? 
ATOM   1962 N N   . ALA A 1 248 ? 24.663  13.882  26.886 1.00 22.46  ? 271 ALA A N   1 ? 
ATOM   1963 C CA  . ALA A 1 248 ? 23.743  14.301  25.808 1.00 20.52  ? 271 ALA A CA  1 ? 
ATOM   1964 C C   . ALA A 1 248 ? 24.512  14.759  24.573 1.00 19.67  ? 271 ALA A C   1 ? 
ATOM   1965 O O   . ALA A 1 248 ? 24.155  14.331  23.472 1.00 21.58  ? 271 ALA A O   1 ? 
ATOM   1966 C CB  . ALA A 1 248 ? 22.845  15.391  26.313 1.00 16.98  ? 271 ALA A CB  1 ? 
ATOM   1967 N N   . GLU A 1 249 ? 25.507  15.617  24.766 1.00 17.07  ? 272 GLU A N   1 ? 
ATOM   1968 C CA  . GLU A 1 249 ? 26.210  16.209  23.601 1.00 21.88  ? 272 GLU A CA  1 ? 
ATOM   1969 C C   . GLU A 1 249 ? 26.933  15.116  22.811 1.00 17.83  ? 272 GLU A C   1 ? 
ATOM   1970 O O   . GLU A 1 249 ? 26.906  15.168  21.589 1.00 20.72  ? 272 GLU A O   1 ? 
ATOM   1971 C CB  . GLU A 1 249 ? 27.182  17.307  24.041 1.00 28.79  ? 272 GLU A CB  1 ? 
ATOM   1972 C CG  . GLU A 1 249 ? 28.450  16.820  24.729 1.00 35.39  ? 272 GLU A CG  1 ? 
ATOM   1973 C CD  . GLU A 1 249 ? 29.640  16.826  23.792 1.00 55.94  ? 272 GLU A CD  1 ? 
ATOM   1974 O OE1 . GLU A 1 249 ? 29.500  17.360  22.675 1.00 74.30  ? 272 GLU A OE1 1 ? 
ATOM   1975 O OE2 . GLU A 1 249 ? 30.702  16.293  24.166 1.00 59.73  ? 272 GLU A OE2 1 ? 
ATOM   1976 N N   . ARG A 1 250 ? 27.481  14.135  23.510 1.00 17.79  ? 273 ARG A N   1 ? 
ATOM   1977 C CA  . ARG A 1 250 ? 28.316  13.122  22.821 1.00 22.12  ? 273 ARG A CA  1 ? 
ATOM   1978 C C   . ARG A 1 250 ? 27.440  12.067  22.137 1.00 18.96  ? 273 ARG A C   1 ? 
ATOM   1979 O O   . ARG A 1 250 ? 27.797  11.626  21.051 1.00 20.09  ? 273 ARG A O   1 ? 
ATOM   1980 C CB  . ARG A 1 250 ? 29.245  12.495  23.860 1.00 21.01  ? 273 ARG A CB  1 ? 
ATOM   1981 C CG  . ARG A 1 250 ? 30.427  11.751  23.264 1.00 26.27  ? 273 ARG A CG  1 ? 
ATOM   1982 C CD  . ARG A 1 250 ? 31.342  11.267  24.366 1.00 34.62  ? 273 ARG A CD  1 ? 
ATOM   1983 N NE  . ARG A 1 250 ? 30.644  10.344  25.265 1.00 30.01  ? 273 ARG A NE  1 ? 
ATOM   1984 C CZ  . ARG A 1 250 ? 30.282  10.615  26.505 1.00 30.76  ? 273 ARG A CZ  1 ? 
ATOM   1985 N NH1 . ARG A 1 250 ? 29.623  9.710   27.200 1.00 34.57  ? 273 ARG A NH1 1 ? 
ATOM   1986 N NH2 . ARG A 1 250 ? 30.586  11.781  27.043 1.00 43.75  ? 273 ARG A NH2 1 ? 
ATOM   1987 N N   . LEU A 1 251 ? 26.366  11.660  22.801 1.00 18.21  ? 274 LEU A N   1 ? 
ATOM   1988 C CA  . LEU A 1 251 ? 25.425  10.682  22.204 1.00 16.84  ? 274 LEU A CA  1 ? 
ATOM   1989 C C   . LEU A 1 251 ? 24.801  11.283  20.933 1.00 17.28  ? 274 LEU A C   1 ? 
ATOM   1990 O O   . LEU A 1 251 ? 24.647  10.561  19.952 1.00 20.72  ? 274 LEU A O   1 ? 
ATOM   1991 C CB  . LEU A 1 251 ? 24.381  10.308  23.245 1.00 16.58  ? 274 LEU A CB  1 ? 
ATOM   1992 C CG  . LEU A 1 251 ? 24.809  9.316   24.327 1.00 23.13  ? 274 LEU A CG  1 ? 
ATOM   1993 C CD1 . LEU A 1 251 ? 23.712  9.228   25.363 1.00 25.24  ? 274 LEU A CD1 1 ? 
ATOM   1994 C CD2 . LEU A 1 251 ? 25.067  7.955   23.716 1.00 25.83  ? 274 LEU A CD2 1 ? 
ATOM   1995 N N   . ASN A 1 252 ? 24.484  12.570  20.962 1.00 14.95  ? 275 ASN A N   1 ? 
ATOM   1996 C CA  . ASN A 1 252 ? 23.938  13.237  19.752 1.00 18.60  ? 275 ASN A CA  1 ? 
ATOM   1997 C C   . ASN A 1 252 ? 25.005  13.265  18.644 1.00 16.81  ? 275 ASN A C   1 ? 
ATOM   1998 O O   . ASN A 1 252 ? 24.659  13.021  17.495 1.00 20.45  ? 275 ASN A O   1 ? 
ATOM   1999 C CB  . ASN A 1 252 ? 23.371  14.615  20.077 1.00 20.23  ? 275 ASN A CB  1 ? 
ATOM   2000 C CG  . ASN A 1 252 ? 21.927  14.554  20.516 1.00 20.09  ? 275 ASN A CG  1 ? 
ATOM   2001 O OD1 . ASN A 1 252 ? 21.036  14.345  19.690 1.00 19.12  ? 275 ASN A OD1 1 ? 
ATOM   2002 N ND2 . ASN A 1 252 ? 21.676  14.737  21.802 1.00 17.28  ? 275 ASN A ND2 1 ? 
ATOM   2003 N N   . ARG A 1 253 ? 26.267  13.495  19.010 1.00 18.66  ? 276 ARG A N   1 ? 
ATOM   2004 C CA  . ARG A 1 253 ? 27.356  13.496  17.994 1.00 17.91  ? 276 ARG A CA  1 ? 
ATOM   2005 C C   . ARG A 1 253 ? 27.484  12.094  17.380 1.00 16.82  ? 276 ARG A C   1 ? 
ATOM   2006 O O   . ARG A 1 253 ? 27.541  11.999  16.157 1.00 18.85  ? 276 ARG A O   1 ? 
ATOM   2007 C CB  . ARG A 1 253 ? 28.675  14.046  18.540 1.00 17.25  ? 276 ARG A CB  1 ? 
ATOM   2008 C CG  . ARG A 1 253 ? 28.700  15.563  18.612 1.00 24.89  ? 276 ARG A CG  1 ? 
ATOM   2009 C CD  . ARG A 1 253 ? 30.098  16.130  18.751 1.00 31.86  ? 276 ARG A CD  1 ? 
ATOM   2010 N NE  . ARG A 1 253 ? 31.058  15.102  19.160 1.00 38.57  ? 276 ARG A NE  1 ? 
ATOM   2011 C CZ  . ARG A 1 253 ? 31.433  14.898  20.409 1.00 36.73  ? 276 ARG A CZ  1 ? 
ATOM   2012 N NH1 . ARG A 1 253 ? 31.072  15.750  21.343 1.00 33.95  ? 276 ARG A NH1 1 ? 
ATOM   2013 N NH2 . ARG A 1 253 ? 32.170  13.851  20.716 1.00 34.71  ? 276 ARG A NH2 1 ? 
ATOM   2014 N N   . ASP A 1 254 ? 27.494  11.068  18.220 1.00 16.59  ? 277 ASP A N   1 ? 
ATOM   2015 C CA  . ASP A 1 254 ? 27.576  9.666   17.725 1.00 22.28  ? 277 ASP A CA  1 ? 
ATOM   2016 C C   . ASP A 1 254 ? 26.368  9.342   16.842 1.00 18.55  ? 277 ASP A C   1 ? 
ATOM   2017 O O   . ASP A 1 254 ? 26.543  8.683   15.825 1.00 18.95  ? 277 ASP A O   1 ? 
ATOM   2018 C CB  . ASP A 1 254 ? 27.697  8.695   18.883 1.00 26.73  ? 277 ASP A CB  1 ? 
ATOM   2019 C CG  . ASP A 1 254 ? 27.829  7.231   18.502 1.00 45.15  ? 277 ASP A CG  1 ? 
ATOM   2020 O OD1 . ASP A 1 254 ? 28.740  6.912   17.714 1.00 51.50  ? 277 ASP A OD1 1 ? 
ATOM   2021 O OD2 . ASP A 1 254 ? 27.020  6.428   19.000 1.00 49.93  ? 277 ASP A OD2 1 ? 
ATOM   2022 N N   . ALA A 1 255 ? 25.184  9.806   17.237 1.00 17.76  ? 278 ALA A N   1 ? 
ATOM   2023 C CA  . ALA A 1 255 ? 23.940  9.526   16.475 1.00 20.17  ? 278 ALA A CA  1 ? 
ATOM   2024 C C   . ALA A 1 255 ? 24.038  10.088  15.052 1.00 20.30  ? 278 ALA A C   1 ? 
ATOM   2025 O O   . ALA A 1 255 ? 23.653  9.413   14.105 1.00 20.35  ? 278 ALA A O   1 ? 
ATOM   2026 C CB  . ALA A 1 255 ? 22.729  10.085  17.196 1.00 15.58  ? 278 ALA A CB  1 ? 
ATOM   2027 N N   . ARG A 1 256 ? 24.540  11.309  14.938 1.00 19.54  ? 279 ARG A N   1 ? 
ATOM   2028 C CA  . ARG A 1 256 ? 24.674  11.946  13.605 1.00 20.22  ? 279 ARG A CA  1 ? 
ATOM   2029 C C   . ARG A 1 256 ? 25.657  11.128  12.768 1.00 21.19  ? 279 ARG A C   1 ? 
ATOM   2030 O O   . ARG A 1 256 ? 25.418  10.958  11.574 1.00 25.42  ? 279 ARG A O   1 ? 
ATOM   2031 C CB  . ARG A 1 256 ? 25.196  13.380  13.744 1.00 19.97  ? 279 ARG A CB  1 ? 
ATOM   2032 C CG  . ARG A 1 256 ? 25.327  14.207  12.478 1.00 17.04  ? 279 ARG A CG  1 ? 
ATOM   2033 C CD  . ARG A 1 256 ? 26.090  15.485  12.762 1.00 19.28  ? 279 ARG A CD  1 ? 
ATOM   2034 N NE  . ARG A 1 256 ? 25.940  16.482  11.698 1.00 20.52  ? 279 ARG A NE  1 ? 
ATOM   2035 C CZ  . ARG A 1 256 ? 26.485  16.392  10.498 1.00 21.28  ? 279 ARG A CZ  1 ? 
ATOM   2036 N NH1 . ARG A 1 256 ? 27.263  15.369  10.198 1.00 22.23  ? 279 ARG A NH1 1 ? 
ATOM   2037 N NH2 . ARG A 1 256 ? 26.257  17.332  9.602  1.00 18.90  ? 279 ARG A NH2 1 ? 
ATOM   2038 N N   . GLN A 1 257 ? 26.717  10.638  13.401 1.00 22.02  ? 280 GLN A N   1 ? 
ATOM   2039 C CA  . GLN A 1 257 ? 27.771  9.939   12.624 1.00 21.97  ? 280 GLN A CA  1 ? 
ATOM   2040 C C   . GLN A 1 257 ? 27.202  8.607   12.115 1.00 21.71  ? 280 GLN A C   1 ? 
ATOM   2041 O O   . GLN A 1 257 ? 27.469  8.244   10.979 1.00 23.93  ? 280 GLN A O   1 ? 
ATOM   2042 C CB  . GLN A 1 257 ? 29.065  9.914   13.444 1.00 24.71  ? 280 GLN A CB  1 ? 
ATOM   2043 C CG  . GLN A 1 257 ? 29.330  8.682   14.296 1.00 36.52  ? 280 GLN A CG  1 ? 
ATOM   2044 C CD  . GLN A 1 257 ? 30.648  8.787   15.032 1.00 52.21  ? 280 GLN A CD  1 ? 
ATOM   2045 O OE1 . GLN A 1 257 ? 31.556  9.518   14.620 1.00 43.26  ? 280 GLN A OE1 1 ? 
ATOM   2046 N NE2 . GLN A 1 257 ? 30.766  8.066   16.136 1.00 43.85  ? 280 GLN A NE2 1 ? 
ATOM   2047 N N   . ARG A 1 258 ? 26.406  7.940   12.940 1.00 21.98  ? 281 ARG A N   1 ? 
ATOM   2048 C CA  . ARG A 1 258 ? 25.825  6.640   12.529 1.00 25.17  ? 281 ARG A CA  1 ? 
ATOM   2049 C C   . ARG A 1 258 ? 24.785  6.849   11.422 1.00 22.79  ? 281 ARG A C   1 ? 
ATOM   2050 O O   . ARG A 1 258 ? 24.656  5.973   10.566 1.00 25.38  ? 281 ARG A O   1 ? 
ATOM   2051 C CB  . ARG A 1 258 ? 25.211  5.898   13.715 1.00 26.01  ? 281 ARG A CB  1 ? 
ATOM   2052 C CG  . ARG A 1 258 ? 26.195  5.613   14.837 1.00 28.27  ? 281 ARG A CG  1 ? 
ATOM   2053 C CD  . ARG A 1 258 ? 25.443  5.384   16.127 1.00 36.69  ? 281 ARG A CD  1 ? 
ATOM   2054 N NE  . ARG A 1 258 ? 26.217  4.594   17.086 1.00 43.68  ? 281 ARG A NE  1 ? 
ATOM   2055 C CZ  . ARG A 1 258 ? 26.052  3.296   17.266 1.00 55.16  ? 281 ARG A CZ  1 ? 
ATOM   2056 N NH1 . ARG A 1 258 ? 25.186  2.635   16.522 1.00 52.66  ? 281 ARG A NH1 1 ? 
ATOM   2057 N NH2 . ARG A 1 258 ? 26.753  2.663   18.189 1.00 58.74  ? 281 ARG A NH2 1 ? 
ATOM   2058 N N   . ILE A 1 259 ? 24.070  7.964   11.463 1.00 20.91  ? 282 ILE A N   1 ? 
ATOM   2059 C CA  . ILE A 1 259 ? 23.091  8.273   10.384 1.00 21.97  ? 282 ILE A CA  1 ? 
ATOM   2060 C C   . ILE A 1 259 ? 23.864  8.521   9.083  1.00 22.16  ? 282 ILE A C   1 ? 
ATOM   2061 O O   . ILE A 1 259 ? 23.535  7.910   8.077  1.00 22.36  ? 282 ILE A O   1 ? 
ATOM   2062 C CB  . ILE A 1 259 ? 22.185  9.462   10.756 1.00 23.02  ? 282 ILE A CB  1 ? 
ATOM   2063 C CG1 . ILE A 1 259 ? 21.262  9.112   11.924 1.00 22.70  ? 282 ILE A CG1 1 ? 
ATOM   2064 C CG2 . ILE A 1 259 ? 21.397  9.953   9.544  1.00 22.19  ? 282 ILE A CG2 1 ? 
ATOM   2065 C CD1 . ILE A 1 259 ? 20.631  10.309  12.612 1.00 23.57  ? 282 ILE A CD1 1 ? 
ATOM   2066 N N   . LEU A 1 260 ? 24.873  9.381   9.145  1.00 23.18  ? 283 LEU A N   1 ? 
ATOM   2067 C CA  . LEU A 1 260 ? 25.690  9.677   7.943  1.00 25.38  ? 283 LEU A CA  1 ? 
ATOM   2068 C C   . LEU A 1 260 ? 26.318  8.374   7.410  1.00 29.16  ? 283 LEU A C   1 ? 
ATOM   2069 O O   . LEU A 1 260 ? 26.324  8.194   6.191  1.00 30.67  ? 283 LEU A O   1 ? 
ATOM   2070 C CB  . LEU A 1 260 ? 26.737  10.741  8.263  1.00 31.53  ? 283 LEU A CB  1 ? 
ATOM   2071 C CG  . LEU A 1 260 ? 27.278  11.541  7.077  1.00 34.31  ? 283 LEU A CG  1 ? 
ATOM   2072 C CD1 . LEU A 1 260 ? 26.160  12.299  6.397  1.00 32.16  ? 283 LEU A CD1 1 ? 
ATOM   2073 C CD2 . LEU A 1 260 ? 28.368  12.494  7.525  1.00 26.65  ? 283 LEU A CD2 1 ? 
ATOM   2074 N N   . ALA A 1 261 ? 26.818  7.515   8.297  1.00 24.18  ? 284 ALA A N   1 ? 
ATOM   2075 C CA  . ALA A 1 261 ? 27.477  6.259   7.880  1.00 30.12  ? 284 ALA A CA  1 ? 
ATOM   2076 C C   . ALA A 1 261 ? 26.479  5.362   7.161  1.00 38.23  ? 284 ALA A C   1 ? 
ATOM   2077 O O   . ALA A 1 261 ? 26.900  4.590   6.287  1.00 37.43  ? 284 ALA A O   1 ? 
ATOM   2078 C CB  . ALA A 1 261 ? 27.998  5.542   9.090  1.00 26.45  ? 284 ALA A CB  1 ? 
ATOM   2079 N N   . SER A 1 262 ? 25.201  5.456   7.526  1.00 41.99  ? 285 SER A N   1 ? 
ATOM   2080 C CA  . SER A 1 262 ? 24.165  4.552   6.963  1.00 31.90  ? 285 SER A CA  1 ? 
ATOM   2081 C C   . SER A 1 262 ? 24.205  4.553   5.431  1.00 36.45  ? 285 SER A C   1 ? 
ATOM   2082 O O   . SER A 1 262 ? 23.992  3.484   4.844  1.00 44.14  ? 285 SER A O   1 ? 
ATOM   2083 C CB  . SER A 1 262 ? 22.821  4.978   7.467  1.00 28.38  ? 285 SER A CB  1 ? 
ATOM   2084 O OG  . SER A 1 262 ? 22.353  6.116   6.760  1.00 31.76  ? 285 SER A OG  1 ? 
ATOM   2085 N N   . GLY A 1 263 ? 24.452  5.707   4.819  1.00 33.00  ? 286 GLY A N   1 ? 
ATOM   2086 C CA  . GLY A 1 263 ? 24.425  5.832   3.354  1.00 39.66  ? 286 GLY A CA  1 ? 
ATOM   2087 C C   . GLY A 1 263 ? 23.005  5.877   2.806  1.00 49.50  ? 286 GLY A C   1 ? 
ATOM   2088 O O   . GLY A 1 263 ? 22.862  6.136   1.602  1.00 48.17  ? 286 GLY A O   1 ? 
ATOM   2089 N N   . ALA A 1 264 ? 21.993  5.639   3.645  1.00 40.52  ? 287 ALA A N   1 ? 
ATOM   2090 C CA  . ALA A 1 264 ? 20.584  5.600   3.200  1.00 35.62  ? 287 ALA A CA  1 ? 
ATOM   2091 C C   . ALA A 1 264 ? 19.904  6.938   3.498  1.00 34.76  ? 287 ALA A C   1 ? 
ATOM   2092 O O   . ALA A 1 264 ? 18.723  7.096   3.198  1.00 27.28  ? 287 ALA A O   1 ? 
ATOM   2093 C CB  . ALA A 1 264 ? 19.890  4.473   3.903  1.00 35.80  ? 287 ALA A CB  1 ? 
ATOM   2094 N N   . SER A 1 265 ? 20.656  7.859   4.085  1.00 28.25  ? 288 SER A N   1 ? 
ATOM   2095 C CA  . SER A 1 265 ? 20.120  9.200   4.400  1.00 30.45  ? 288 SER A CA  1 ? 
ATOM   2096 C C   . SER A 1 265 ? 21.245  10.217  4.204  1.00 27.72  ? 288 SER A C   1 ? 
ATOM   2097 O O   . SER A 1 265 ? 22.407  9.866   4.422  1.00 31.47  ? 288 SER A O   1 ? 
ATOM   2098 C CB  . SER A 1 265 ? 19.523  9.273   5.801  1.00 22.23  ? 288 SER A CB  1 ? 
ATOM   2099 O OG  . SER A 1 265 ? 18.532  8.284   6.021  1.00 23.02  ? 288 SER A OG  1 ? 
ATOM   2100 N N   . GLU A 1 266 ? 20.888  11.407  3.750  1.00 23.94  ? 289 GLU A N   1 ? 
ATOM   2101 C CA  . GLU A 1 266 ? 21.889  12.468  3.579  1.00 27.09  ? 289 GLU A CA  1 ? 
ATOM   2102 C C   . GLU A 1 266 ? 21.614  13.588  4.583  1.00 29.17  ? 289 GLU A C   1 ? 
ATOM   2103 O O   . GLU A 1 266 ? 20.468  13.765  4.983  1.00 30.61  ? 289 GLU A O   1 ? 
ATOM   2104 C CB  . GLU A 1 266 ? 21.817  13.075  2.183  1.00 28.20  ? 289 GLU A CB  1 ? 
ATOM   2105 C CG  . GLU A 1 266 ? 21.705  12.068  1.045  1.00 35.70  ? 289 GLU A CG  1 ? 
ATOM   2106 C CD  . GLU A 1 266 ? 21.531  12.785  -0.281 1.00 39.39  ? 289 GLU A CD  1 ? 
ATOM   2107 O OE1 . GLU A 1 266 ? 21.186  12.124  -1.274 1.00 54.00  ? 289 GLU A OE1 1 ? 
ATOM   2108 O OE2 . GLU A 1 266 ? 21.735  14.012  -0.320 1.00 41.88  ? 289 GLU A OE2 1 ? 
ATOM   2109 N N   . ILE A 1 267 ? 22.657  14.311  4.936  1.00 21.45  ? 290 ILE A N   1 ? 
ATOM   2110 C CA  . ILE A 1 267 ? 22.483  15.460  5.846  1.00 21.04  ? 290 ILE A CA  1 ? 
ATOM   2111 C C   . ILE A 1 267 ? 22.997  16.711  5.138  1.00 25.40  ? 290 ILE A C   1 ? 
ATOM   2112 O O   . ILE A 1 267 ? 24.142  16.684  4.675  1.00 29.69  ? 290 ILE A O   1 ? 
ATOM   2113 C CB  . ILE A 1 267 ? 23.232  15.251  7.172  1.00 18.58  ? 290 ILE A CB  1 ? 
ATOM   2114 C CG1 . ILE A 1 267 ? 22.798  13.974  7.892  1.00 18.41  ? 290 ILE A CG1 1 ? 
ATOM   2115 C CG2 . ILE A 1 267 ? 23.110  16.484  8.068  1.00 20.37  ? 290 ILE A CG2 1 ? 
ATOM   2116 C CD1 . ILE A 1 267 ? 23.659  13.618  9.087  1.00 17.85  ? 290 ILE A CD1 1 ? 
ATOM   2117 N N   . HIS A 1 268 ? 22.161  17.729  5.034  1.00 25.42  ? 291 HIS A N   1 ? 
ATOM   2118 C CA  . HIS A 1 268 ? 22.632  19.036  4.526  1.00 29.12  ? 291 HIS A CA  1 ? 
ATOM   2119 C C   . HIS A 1 268 ? 22.772  19.949  5.745  1.00 29.71  ? 291 HIS A C   1 ? 
ATOM   2120 O O   . HIS A 1 268 ? 21.845  20.026  6.547  1.00 27.72  ? 291 HIS A O   1 ? 
ATOM   2121 C CB  . HIS A 1 268 ? 21.689  19.612  3.465  1.00 34.10  ? 291 HIS A CB  1 ? 
ATOM   2122 C CG  . HIS A 1 268 ? 21.912  21.055  3.182  1.00 38.33  ? 291 HIS A CG  1 ? 
ATOM   2123 N ND1 . HIS A 1 268 ? 22.918  21.498  2.355  1.00 42.90  ? 291 HIS A ND1 1 ? 
ATOM   2124 C CD2 . HIS A 1 268 ? 21.268  22.148  3.600  1.00 45.06  ? 291 HIS A CD2 1 ? 
ATOM   2125 C CE1 . HIS A 1 268 ? 22.876  22.819  2.290  1.00 43.18  ? 291 HIS A CE1 1 ? 
ATOM   2126 N NE2 . HIS A 1 268 ? 21.883  23.233  3.039  1.00 42.78  ? 291 HIS A NE2 1 ? 
ATOM   2127 N N   . THR A 1 269 ? 23.919  20.611  5.870  1.00 27.66  ? 292 THR A N   1 ? 
ATOM   2128 C CA  . THR A 1 269 ? 24.105  21.567  6.970  1.00 28.47  ? 292 THR A CA  1 ? 
ATOM   2129 C C   . THR A 1 269 ? 23.819  22.941  6.423  1.00 31.97  ? 292 THR A C   1 ? 
ATOM   2130 O O   . THR A 1 269 ? 24.333  23.290  5.364  1.00 35.06  ? 292 THR A O   1 ? 
ATOM   2131 C CB  . THR A 1 269 ? 25.483  21.457  7.624  1.00 26.22  ? 292 THR A CB  1 ? 
ATOM   2132 O OG1 . THR A 1 269 ? 25.732  20.090  7.935  1.00 31.77  ? 292 THR A OG1 1 ? 
ATOM   2133 C CG2 . THR A 1 269 ? 25.569  22.267  8.904  1.00 27.82  ? 292 THR A CG2 1 ? 
ATOM   2134 N N   . LEU A 1 270 ? 23.007  23.700  7.136  1.00 32.35  ? 293 LEU A N   1 ? 
ATOM   2135 C CA  . LEU A 1 270 ? 22.614  25.021  6.610  1.00 32.78  ? 293 LEU A CA  1 ? 
ATOM   2136 C C   . LEU A 1 270 ? 23.775  26.010  6.738  1.00 34.51  ? 293 LEU A C   1 ? 
ATOM   2137 O O   . LEU A 1 270 ? 24.456  25.984  7.772  1.00 39.38  ? 293 LEU A O   1 ? 
ATOM   2138 C CB  . LEU A 1 270 ? 21.402  25.529  7.383  1.00 26.16  ? 293 LEU A CB  1 ? 
ATOM   2139 C CG  . LEU A 1 270 ? 20.055  24.858  7.119  1.00 25.54  ? 293 LEU A CG  1 ? 
ATOM   2140 C CD1 . LEU A 1 270 ? 19.026  25.570  7.971  1.00 26.57  ? 293 LEU A CD1 1 ? 
ATOM   2141 C CD2 . LEU A 1 270 ? 19.681  24.932  5.652  1.00 18.94  ? 293 LEU A CD2 1 ? 
ATOM   2142 N N   . SER A 1 271 ? 23.947  26.873  5.752  1.00 34.31  ? 294 SER A N   1 ? 
ATOM   2143 C CA  . SER A 1 271 ? 24.925  27.979  5.851  1.00 33.06  ? 294 SER A CA  1 ? 
ATOM   2144 C C   . SER A 1 271 ? 24.380  29.031  6.821  1.00 33.79  ? 294 SER A C   1 ? 
ATOM   2145 O O   . SER A 1 271 ? 23.165  29.057  7.033  1.00 36.64  ? 294 SER A O   1 ? 
ATOM   2146 C CB  . SER A 1 271 ? 25.106  28.607  4.503  1.00 31.50  ? 294 SER A CB  1 ? 
ATOM   2147 O OG  . SER A 1 271 ? 24.030  29.471  4.174  1.00 36.11  ? 294 SER A OG  1 ? 
ATOM   2148 N N   . PRO A 1 272 ? 25.218  29.925  7.380  1.00 36.01  ? 295 PRO A N   1 ? 
ATOM   2149 C CA  . PRO A 1 272 ? 24.711  31.003  8.212  1.00 35.14  ? 295 PRO A CA  1 ? 
ATOM   2150 C C   . PRO A 1 272 ? 23.600  31.787  7.545  1.00 27.63  ? 295 PRO A C   1 ? 
ATOM   2151 O O   . PRO A 1 272 ? 22.619  32.167  8.178  1.00 26.99  ? 295 PRO A O   1 ? 
ATOM   2152 C CB  . PRO A 1 272 ? 25.986  31.832  8.381  1.00 33.81  ? 295 PRO A CB  1 ? 
ATOM   2153 C CG  . PRO A 1 272 ? 27.085  30.812  8.401  1.00 33.40  ? 295 PRO A CG  1 ? 
ATOM   2154 C CD  . PRO A 1 272 ? 26.665  29.867  7.301  1.00 30.44  ? 295 PRO A CD  1 ? 
ATOM   2155 N N   . GLN A 1 273 ? 23.754  32.008  6.255  1.00 32.61  ? 296 GLN A N   1 ? 
ATOM   2156 C CA  . GLN A 1 273 ? 22.771  32.818  5.507  1.00 34.71  ? 296 GLN A CA  1 ? 
ATOM   2157 C C   . GLN A 1 273 ? 21.473  32.022  5.346  1.00 32.56  ? 296 GLN A C   1 ? 
ATOM   2158 O O   . GLN A 1 273 ? 20.402  32.600  5.519  1.00 32.83  ? 296 GLN A O   1 ? 
ATOM   2159 C CB  . GLN A 1 273 ? 23.428  33.188  4.181  1.00 44.31  ? 296 GLN A CB  1 ? 
ATOM   2160 C CG  . GLN A 1 273 ? 24.777  33.884  4.324  1.00 59.11  ? 296 GLN A CG  1 ? 
ATOM   2161 C CD  . GLN A 1 273 ? 25.944  32.929  4.453  1.00 63.53  ? 296 GLN A CD  1 ? 
ATOM   2162 O OE1 . GLN A 1 273 ? 25.843  31.741  4.138  1.00 73.19  ? 296 GLN A OE1 1 ? 
ATOM   2163 N NE2 . GLN A 1 273 ? 27.067  33.438  4.934  1.00 66.74  ? 296 GLN A NE2 1 ? 
ATOM   2164 N N   . GLN A 1 274 ? 21.593  30.741  5.023  1.00 29.55  ? 297 GLN A N   1 ? 
ATOM   2165 C CA  . GLN A 1 274 ? 20.386  29.893  4.891  1.00 31.40  ? 297 GLN A CA  1 ? 
ATOM   2166 C C   . GLN A 1 274 ? 19.675  29.847  6.253  1.00 30.54  ? 297 GLN A C   1 ? 
ATOM   2167 O O   . GLN A 1 274 ? 18.457  30.039  6.289  1.00 33.06  ? 297 GLN A O   1 ? 
ATOM   2168 C CB  . GLN A 1 274 ? 20.758  28.477  4.471  1.00 31.01  ? 297 GLN A CB  1 ? 
ATOM   2169 C CG  . GLN A 1 274 ? 20.751  28.217  2.971  1.00 29.84  ? 297 GLN A CG  1 ? 
ATOM   2170 C CD  . GLN A 1 274 ? 21.299  26.851  2.623  1.00 32.09  ? 297 GLN A CD  1 ? 
ATOM   2171 O OE1 . GLN A 1 274 ? 22.186  26.325  3.301  1.00 32.22  ? 297 GLN A OE1 1 ? 
ATOM   2172 N NE2 . GLN A 1 274 ? 20.769  26.256  1.567  1.00 38.24  ? 297 GLN A NE2 1 ? 
ATOM   2173 N N   . ARG A 1 275 ? 20.432  29.604  7.325  1.00 26.70  ? 298 ARG A N   1 ? 
ATOM   2174 C CA  . ARG A 1 275 ? 19.835  29.578  8.687  1.00 26.46  ? 298 ARG A CA  1 ? 
ATOM   2175 C C   . ARG A 1 275 ? 19.023  30.862  8.914  1.00 26.91  ? 298 ARG A C   1 ? 
ATOM   2176 O O   . ARG A 1 275 ? 17.882  30.766  9.358  1.00 26.83  ? 298 ARG A O   1 ? 
ATOM   2177 C CB  . ARG A 1 275 ? 20.891  29.384  9.778  1.00 29.54  ? 298 ARG A CB  1 ? 
ATOM   2178 C CG  . ARG A 1 275 ? 20.289  28.668  10.978 1.00 32.58  ? 298 ARG A CG  1 ? 
ATOM   2179 C CD  . ARG A 1 275 ? 21.302  28.203  12.005 1.00 34.82  ? 298 ARG A CD  1 ? 
ATOM   2180 N NE  . ARG A 1 275 ? 20.678  27.693  13.231 1.00 34.06  ? 298 ARG A NE  1 ? 
ATOM   2181 C CZ  . ARG A 1 275 ? 20.448  28.422  14.314 1.00 38.99  ? 298 ARG A CZ  1 ? 
ATOM   2182 N NH1 . ARG A 1 275 ? 20.450  29.739  14.239 1.00 41.20  ? 298 ARG A NH1 1 ? 
ATOM   2183 N NH2 . ARG A 1 275 ? 20.221  27.840  15.473 1.00 28.59  ? 298 ARG A NH2 1 ? 
ATOM   2184 N N   . ALA A 1 276 ? 19.600  32.015  8.586  1.00 27.30  ? 299 ALA A N   1 ? 
ATOM   2185 C CA  . ALA A 1 276 ? 18.910  33.312  8.791  1.00 30.46  ? 299 ALA A CA  1 ? 
ATOM   2186 C C   . ALA A 1 276 ? 17.609  33.393  7.998  1.00 28.10  ? 299 ALA A C   1 ? 
ATOM   2187 O O   . ALA A 1 276 ? 16.659  34.020  8.464  1.00 30.05  ? 299 ALA A O   1 ? 
ATOM   2188 C CB  . ALA A 1 276 ? 19.832  34.435  8.402  1.00 26.05  ? 299 ALA A CB  1 ? 
ATOM   2189 N N   . ASP A 1 277 ? 17.584  32.797  6.810  1.00 26.84  ? 300 ASP A N   1 ? 
ATOM   2190 C CA  . ASP A 1 277 ? 16.368  32.857  5.954  1.00 30.46  ? 300 ASP A CA  1 ? 
ATOM   2191 C C   . ASP A 1 277 ? 15.293  31.948  6.562  1.00 27.80  ? 300 ASP A C   1 ? 
ATOM   2192 O O   . ASP A 1 277 ? 14.133  32.343  6.597  1.00 28.17  ? 300 ASP A O   1 ? 
ATOM   2193 C CB  . ASP A 1 277 ? 16.722  32.566  4.503  1.00 34.00  ? 300 ASP A CB  1 ? 
ATOM   2194 C CG  . ASP A 1 277 ? 17.551  33.638  3.810  1.00 34.38  ? 300 ASP A CG  1 ? 
ATOM   2195 O OD1 . ASP A 1 277 ? 17.526  34.788  4.280  1.00 29.19  ? 300 ASP A OD1 1 ? 
ATOM   2196 O OD2 . ASP A 1 277 ? 18.215  33.312  2.808  1.00 33.47  ? 300 ASP A OD2 1 ? 
ATOM   2197 N N   . TRP A 1 278 ? 15.697  30.784  7.042  1.00 25.93  ? 301 TRP A N   1 ? 
ATOM   2198 C CA  . TRP A 1 278 ? 14.762  29.883  7.754  1.00 25.53  ? 301 TRP A CA  1 ? 
ATOM   2199 C C   . TRP A 1 278 ? 14.228  30.582  9.015  1.00 23.63  ? 301 TRP A C   1 ? 
ATOM   2200 O O   . TRP A 1 278 ? 13.032  30.542  9.265  1.00 27.87  ? 301 TRP A O   1 ? 
ATOM   2201 C CB  . TRP A 1 278 ? 15.485  28.576  8.090  1.00 21.20  ? 301 TRP A CB  1 ? 
ATOM   2202 C CG  . TRP A 1 278 ? 15.550  27.573  6.974  1.00 26.16  ? 301 TRP A CG  1 ? 
ATOM   2203 C CD1 . TRP A 1 278 ? 16.496  27.484  5.998  1.00 26.69  ? 301 TRP A CD1 1 ? 
ATOM   2204 C CD2 . TRP A 1 278 ? 14.629  26.489  6.744  1.00 22.77  ? 301 TRP A CD2 1 ? 
ATOM   2205 N NE1 . TRP A 1 278 ? 16.227  26.426  5.175  1.00 31.41  ? 301 TRP A NE1 1 ? 
ATOM   2206 C CE2 . TRP A 1 278 ? 15.089  25.797  5.605  1.00 26.30  ? 301 TRP A CE2 1 ? 
ATOM   2207 C CE3 . TRP A 1 278 ? 13.467  26.043  7.380  1.00 21.70  ? 301 TRP A CE3 1 ? 
ATOM   2208 C CZ2 . TRP A 1 278 ? 14.427  24.685  5.096  1.00 28.83  ? 301 TRP A CZ2 1 ? 
ATOM   2209 C CZ3 . TRP A 1 278 ? 12.812  24.946  6.870  1.00 24.38  ? 301 TRP A CZ3 1 ? 
ATOM   2210 C CH2 . TRP A 1 278 ? 13.289  24.274  5.748  1.00 22.58  ? 301 TRP A CH2 1 ? 
ATOM   2211 N N   . ARG A 1 279 ? 15.103  31.238  9.764  1.00 28.96  ? 302 ARG A N   1 ? 
ATOM   2212 C CA  . ARG A 1 279 ? 14.671  31.990  10.970 1.00 30.16  ? 302 ARG A CA  1 ? 
ATOM   2213 C C   . ARG A 1 279 ? 13.691  33.105  10.565 1.00 29.94  ? 302 ARG A C   1 ? 
ATOM   2214 O O   . ARG A 1 279 ? 12.618  33.196  11.149 1.00 24.28  ? 302 ARG A O   1 ? 
ATOM   2215 C CB  . ARG A 1 279 ? 15.875  32.591  11.688 1.00 23.82  ? 302 ARG A CB  1 ? 
ATOM   2216 C CG  . ARG A 1 279 ? 15.476  33.485  12.850 1.00 30.84  ? 302 ARG A CG  1 ? 
ATOM   2217 C CD  . ARG A 1 279 ? 16.643  33.838  13.744 1.00 29.33  ? 302 ARG A CD  1 ? 
ATOM   2218 N NE  . ARG A 1 279 ? 16.209  34.653  14.882 1.00 33.49  ? 302 ARG A NE  1 ? 
ATOM   2219 C CZ  . ARG A 1 279 ? 16.678  34.528  16.116 1.00 40.06  ? 302 ARG A CZ  1 ? 
ATOM   2220 N NH1 . ARG A 1 279 ? 17.759  33.808  16.342 1.00 29.32  ? 302 ARG A NH1 1 ? 
ATOM   2221 N NH2 . ARG A 1 279 ? 16.062  35.124  17.119 1.00 36.77  ? 302 ARG A NH2 1 ? 
ATOM   2222 N N   . GLN A 1 280 ? 14.068  33.911  9.576  1.00 27.45  ? 303 GLN A N   1 ? 
ATOM   2223 C CA  . GLN A 1 280 ? 13.154  34.975  9.093  1.00 31.29  ? 303 GLN A CA  1 ? 
ATOM   2224 C C   . GLN A 1 280 ? 11.782  34.386  8.740  1.00 27.02  ? 303 GLN A C   1 ? 
ATOM   2225 O O   . GLN A 1 280 ? 10.790  35.085  8.898  1.00 26.77  ? 303 GLN A O   1 ? 
ATOM   2226 C CB  . GLN A 1 280 ? 13.704  35.693  7.858  1.00 31.00  ? 303 GLN A CB  1 ? 
ATOM   2227 C CG  . GLN A 1 280 ? 13.028  37.019  7.536  1.00 41.79  ? 303 GLN A CG  1 ? 
ATOM   2228 C CD  . GLN A 1 280 ? 13.328  37.508  6.136  1.00 59.79  ? 303 GLN A CD  1 ? 
ATOM   2229 O OE1 . GLN A 1 280 ? 14.250  37.029  5.469  1.00 62.64  ? 303 GLN A OE1 1 ? 
ATOM   2230 N NE2 . GLN A 1 280 ? 12.549  38.475  5.676  1.00 75.17  ? 303 GLN A NE2 1 ? 
ATOM   2231 N N   . ALA A 1 281 ? 11.749  33.148  8.253  1.00 24.35  ? 304 ALA A N   1 ? 
ATOM   2232 C CA  . ALA A 1 281 ? 10.467  32.568  7.797  1.00 25.03  ? 304 ALA A CA  1 ? 
ATOM   2233 C C   . ALA A 1 281 ? 9.673   31.991  8.965  1.00 26.55  ? 304 ALA A C   1 ? 
ATOM   2234 O O   . ALA A 1 281 ? 8.451   31.992  8.897  1.00 28.41  ? 304 ALA A O   1 ? 
ATOM   2235 C CB  . ALA A 1 281 ? 10.743  31.521  6.756  1.00 26.62  ? 304 ALA A CB  1 ? 
ATOM   2236 N N   . MET A 1 282 ? 10.357  31.544  10.009 1.00 24.69  ? 305 MET A N   1 ? 
ATOM   2237 C CA  . MET A 1 282 ? 9.649   30.850  11.109 1.00 24.33  ? 305 MET A CA  1 ? 
ATOM   2238 C C   . MET A 1 282 ? 9.392   31.795  12.291 1.00 26.98  ? 305 MET A C   1 ? 
ATOM   2239 O O   . MET A 1 282 ? 8.334   31.679  12.906 1.00 34.75  ? 305 MET A O   1 ? 
ATOM   2240 C CB  . MET A 1 282 ? 10.469  29.632  11.543 1.00 23.61  ? 305 MET A CB  1 ? 
ATOM   2241 C CG  . MET A 1 282 ? 10.642  28.599  10.452 1.00 25.71  ? 305 MET A CG  1 ? 
ATOM   2242 S SD  . MET A 1 282 ? 11.867  27.325  10.809 1.00 37.24  ? 305 MET A SD  1 ? 
ATOM   2243 C CE  . MET A 1 282 ? 11.229  26.704  12.366 1.00 36.63  ? 305 MET A CE  1 ? 
ATOM   2244 N N   . GLN A 1 283 ? 10.300  32.719  12.560 1.00 29.05  ? 306 GLN A N   1 ? 
ATOM   2245 C CA  . GLN A 1 283 ? 10.175  33.611  13.747 1.00 31.63  ? 306 GLN A CA  1 ? 
ATOM   2246 C C   . GLN A 1 283 ? 8.817   34.341  13.810 1.00 27.27  ? 306 GLN A C   1 ? 
ATOM   2247 O O   . GLN A 1 283 ? 8.398   34.669  14.916 1.00 27.94  ? 306 GLN A O   1 ? 
ATOM   2248 C CB  . GLN A 1 283 ? 11.395  34.528  13.823 1.00 31.86  ? 306 GLN A CB  1 ? 
ATOM   2249 C CG  . GLN A 1 283 ? 11.358  35.531  14.968 1.00 40.26  ? 306 GLN A CG  1 ? 
ATOM   2250 C CD  . GLN A 1 283 ? 12.719  35.772  15.575 1.00 47.78  ? 306 GLN A CD  1 ? 
ATOM   2251 O OE1 . GLN A 1 283 ? 13.682  35.061  15.280 1.00 50.25  ? 306 GLN A OE1 1 ? 
ATOM   2252 N NE2 . GLN A 1 283 ? 12.811  36.784  16.422 1.00 49.07  ? 306 GLN A NE2 1 ? 
ATOM   2253 N N   . PRO A 1 284 ? 8.105   34.661  12.710 1.00 31.98  ? 307 PRO A N   1 ? 
ATOM   2254 C CA  . PRO A 1 284 ? 6.771   35.233  12.836 1.00 29.05  ? 307 PRO A CA  1 ? 
ATOM   2255 C C   . PRO A 1 284 ? 5.824   34.491  13.789 1.00 25.95  ? 307 PRO A C   1 ? 
ATOM   2256 O O   . PRO A 1 284 ? 4.901   35.126  14.303 1.00 25.85  ? 307 PRO A O   1 ? 
ATOM   2257 C CB  . PRO A 1 284 ? 6.291   35.205  11.381 1.00 28.61  ? 307 PRO A CB  1 ? 
ATOM   2258 C CG  . PRO A 1 284 ? 7.526   35.520  10.597 1.00 31.81  ? 307 PRO A CG  1 ? 
ATOM   2259 C CD  . PRO A 1 284 ? 8.570   34.712  11.328 1.00 34.10  ? 307 PRO A CD  1 ? 
ATOM   2260 N N   . VAL A 1 285 ? 6.062   33.197  14.023 1.00 24.40  ? 308 VAL A N   1 ? 
ATOM   2261 C CA  . VAL A 1 285 ? 5.226   32.386  14.969 1.00 27.94  ? 308 VAL A CA  1 ? 
ATOM   2262 C C   . VAL A 1 285 ? 5.322   32.930  16.406 1.00 25.72  ? 308 VAL A C   1 ? 
ATOM   2263 O O   . VAL A 1 285 ? 4.366   32.747  17.164 1.00 21.84  ? 308 VAL A O   1 ? 
ATOM   2264 C CB  . VAL A 1 285 ? 5.545   30.880  14.957 1.00 29.47  ? 308 VAL A CB  1 ? 
ATOM   2265 C CG1 . VAL A 1 285 ? 5.491   30.297  13.558 1.00 36.72  ? 308 VAL A CG1 1 ? 
ATOM   2266 C CG2 . VAL A 1 285 ? 6.847   30.541  15.661 1.00 24.99  ? 308 VAL A CG2 1 ? 
ATOM   2267 N N   . TRP A 1 286 ? 6.423   33.588  16.741 1.00 23.60  ? 309 TRP A N   1 ? 
ATOM   2268 C CA  . TRP A 1 286 ? 6.618   34.085  18.118 1.00 19.53  ? 309 TRP A CA  1 ? 
ATOM   2269 C C   . TRP A 1 286 ? 5.475   35.021  18.528 1.00 26.69  ? 309 TRP A C   1 ? 
ATOM   2270 O O   . TRP A 1 286 ? 5.102   35.024  19.702 1.00 26.60  ? 309 TRP A O   1 ? 
ATOM   2271 C CB  . TRP A 1 286 ? 7.952   34.821  18.229 1.00 21.42  ? 309 TRP A CB  1 ? 
ATOM   2272 C CG  . TRP A 1 286 ? 9.212   34.013  18.109 1.00 22.93  ? 309 TRP A CG  1 ? 
ATOM   2273 C CD1 . TRP A 1 286 ? 9.403   32.789  17.541 1.00 19.40  ? 309 TRP A CD1 1 ? 
ATOM   2274 C CD2 . TRP A 1 286 ? 10.507  34.449  18.569 1.00 23.59  ? 309 TRP A CD2 1 ? 
ATOM   2275 N NE1 . TRP A 1 286 ? 10.721  32.430  17.624 1.00 20.97  ? 309 TRP A NE1 1 ? 
ATOM   2276 C CE2 . TRP A 1 286 ? 11.422  33.427  18.248 1.00 24.33  ? 309 TRP A CE2 1 ? 
ATOM   2277 C CE3 . TRP A 1 286 ? 10.972  35.598  19.216 1.00 24.44  ? 309 TRP A CE3 1 ? 
ATOM   2278 C CZ2 . TRP A 1 286 ? 12.775  33.527  18.557 1.00 27.99  ? 309 TRP A CZ2 1 ? 
ATOM   2279 C CZ3 . TRP A 1 286 ? 12.310  35.691  19.523 1.00 22.76  ? 309 TRP A CZ3 1 ? 
ATOM   2280 C CH2 . TRP A 1 286 ? 13.198  34.673  19.187 1.00 22.78  ? 309 TRP A CH2 1 ? 
ATOM   2281 N N   . GLN A 1 287 ? 4.948   35.792  17.587 1.00 26.70  ? 310 GLN A N   1 ? 
ATOM   2282 C CA  . GLN A 1 287 ? 3.921   36.814  17.929 1.00 30.78  ? 310 GLN A CA  1 ? 
ATOM   2283 C C   . GLN A 1 287 ? 2.658   36.141  18.472 1.00 28.39  ? 310 GLN A C   1 ? 
ATOM   2284 O O   . GLN A 1 287 ? 1.938   36.771  19.251 1.00 23.07  ? 310 GLN A O   1 ? 
ATOM   2285 C CB  . GLN A 1 287 ? 3.575   37.683  16.722 1.00 27.71  ? 310 GLN A CB  1 ? 
ATOM   2286 C CG  . GLN A 1 287 ? 4.749   37.991  15.798 1.00 53.56  ? 310 GLN A CG  1 ? 
ATOM   2287 C CD  . GLN A 1 287 ? 6.019   38.401  16.514 1.00 81.79  ? 310 GLN A CD  1 ? 
ATOM   2288 O OE1 . GLN A 1 287 ? 6.017   39.279  17.383 1.00 74.86  ? 310 GLN A OE1 1 ? 
ATOM   2289 N NE2 . GLN A 1 287 ? 7.124   37.767  16.143 1.00 74.49  ? 310 GLN A NE2 1 ? 
ATOM   2290 N N   . LYS A 1 288 ? 2.412   34.908  18.050 1.00 22.03  ? 311 LYS A N   1 ? 
ATOM   2291 C CA  . LYS A 1 288 ? 1.190   34.205  18.492 1.00 25.24  ? 311 LYS A CA  1 ? 
ATOM   2292 C C   . LYS A 1 288 ? 1.300   33.797  19.969 1.00 25.78  ? 311 LYS A C   1 ? 
ATOM   2293 O O   . LYS A 1 288 ? 0.239   33.603  20.567 1.00 28.13  ? 311 LYS A O   1 ? 
ATOM   2294 C CB  . LYS A 1 288 ? 0.913   32.985  17.612 1.00 29.25  ? 311 LYS A CB  1 ? 
ATOM   2295 C CG  . LYS A 1 288 ? 1.151   33.216  16.137 1.00 39.05  ? 311 LYS A CG  1 ? 
ATOM   2296 C CD  . LYS A 1 288 ? 0.099   34.112  15.504 1.00 55.71  ? 311 LYS A CD  1 ? 
ATOM   2297 C CE  . LYS A 1 288 ? -0.063  33.802  14.053 1.00 57.55  ? 311 LYS A CE  1 ? 
ATOM   2298 N NZ  . LYS A 1 288 ? 0.072   32.367  13.805 1.00 53.20  ? 311 LYS A NZ  1 ? 
ATOM   2299 N N   . PHE A 1 289 ? 2.508   33.700  20.521 1.00 21.05  ? 312 PHE A N   1 ? 
ATOM   2300 C CA  . PHE A 1 289 ? 2.678   33.169  21.906 1.00 22.24  ? 312 PHE A CA  1 ? 
ATOM   2301 C C   . PHE A 1 289 ? 3.299   34.198  22.857 1.00 22.82  ? 312 PHE A C   1 ? 
ATOM   2302 O O   . PHE A 1 289 ? 3.408   33.929  24.045 1.00 21.38  ? 312 PHE A O   1 ? 
ATOM   2303 C CB  . PHE A 1 289 ? 3.529   31.908  21.796 1.00 18.35  ? 312 PHE A CB  1 ? 
ATOM   2304 C CG  . PHE A 1 289 ? 2.874   30.872  20.898 1.00 16.97  ? 312 PHE A CG  1 ? 
ATOM   2305 C CD1 . PHE A 1 289 ? 1.814   30.107  21.362 1.00 16.52  ? 312 PHE A CD1 1 ? 
ATOM   2306 C CD2 . PHE A 1 289 ? 3.294   30.696  19.587 1.00 20.10  ? 312 PHE A CD2 1 ? 
ATOM   2307 C CE1 . PHE A 1 289 ? 1.201   29.182  20.540 1.00 19.51  ? 312 PHE A CE1 1 ? 
ATOM   2308 C CE2 . PHE A 1 289 ? 2.675   29.769  18.771 1.00 19.04  ? 312 PHE A CE2 1 ? 
ATOM   2309 C CZ  . PHE A 1 289 ? 1.629   29.020  19.247 1.00 19.21  ? 312 PHE A CZ  1 ? 
ATOM   2310 N N   . ARG A 1 290 ? 3.681   35.349  22.329 1.00 24.51  ? 313 ARG A N   1 ? 
ATOM   2311 C CA  . ARG A 1 290 ? 4.376   36.373  23.146 1.00 29.42  ? 313 ARG A CA  1 ? 
ATOM   2312 C C   . ARG A 1 290 ? 3.564   36.755  24.380 1.00 25.52  ? 313 ARG A C   1 ? 
ATOM   2313 O O   . ARG A 1 290 ? 4.161   37.005  25.430 1.00 29.70  ? 313 ARG A O   1 ? 
ATOM   2314 C CB  . ARG A 1 290 ? 4.619   37.626  22.299 1.00 36.27  ? 313 ARG A CB  1 ? 
ATOM   2315 C CG  . ARG A 1 290 ? 5.517   38.655  22.963 1.00 46.81  ? 313 ARG A CG  1 ? 
ATOM   2316 C CD  . ARG A 1 290 ? 5.615   39.885  22.087 1.00 65.91  ? 313 ARG A CD  1 ? 
ATOM   2317 N NE  . ARG A 1 290 ? 6.059   39.536  20.734 1.00 79.58  ? 313 ARG A NE  1 ? 
ATOM   2318 C CZ  . ARG A 1 290 ? 7.329   39.430  20.378 1.00 79.59  ? 313 ARG A CZ  1 ? 
ATOM   2319 N NH1 . ARG A 1 290 ? 7.703   38.471  19.552 1.00 59.95  ? 313 ARG A NH1 1 ? 
ATOM   2320 N NH2 . ARG A 1 290 ? 8.218   40.281  20.856 1.00 65.70  ? 313 ARG A NH2 1 ? 
ATOM   2321 N N   . GLY A 1 291 ? 2.258   36.841  24.231 1.00 27.06  ? 314 GLY A N   1 ? 
ATOM   2322 C CA  . GLY A 1 291 ? 1.407   37.233  25.367 1.00 23.10  ? 314 GLY A CA  1 ? 
ATOM   2323 C C   . GLY A 1 291 ? 1.402   36.160  26.433 1.00 26.66  ? 314 GLY A C   1 ? 
ATOM   2324 O O   . GLY A 1 291 ? 1.419   36.513  27.612 1.00 27.82  ? 314 GLY A O   1 ? 
ATOM   2325 N N   . ASN A 1 292 ? 1.404   34.890  26.027 1.00 21.92  ? 315 ASN A N   1 ? 
ATOM   2326 C CA  . ASN A 1 292 ? 1.451   33.769  26.996 1.00 25.40  ? 315 ASN A CA  1 ? 
ATOM   2327 C C   . ASN A 1 292 ? 2.773   33.760  27.767 1.00 24.43  ? 315 ASN A C   1 ? 
ATOM   2328 O O   . ASN A 1 292 ? 2.753   33.513  28.967 1.00 21.43  ? 315 ASN A O   1 ? 
ATOM   2329 C CB  . ASN A 1 292 ? 1.325   32.420  26.307 1.00 24.96  ? 315 ASN A CB  1 ? 
ATOM   2330 C CG  . ASN A 1 292 ? -0.039  32.166  25.719 1.00 27.20  ? 315 ASN A CG  1 ? 
ATOM   2331 O OD1 . ASN A 1 292 ? -0.993  32.885  26.026 1.00 32.98  ? 315 ASN A OD1 1 ? 
ATOM   2332 N ND2 . ASN A 1 292 ? -0.147  31.156  24.871 1.00 27.27  ? 315 ASN A ND2 1 ? 
ATOM   2333 N N   . VAL A 1 293 ? 3.887   33.945  27.068 1.00 24.25  ? 316 VAL A N   1 ? 
ATOM   2334 C CA  . VAL A 1 293 ? 5.204   33.811  27.758 1.00 22.21  ? 316 VAL A CA  1 ? 
ATOM   2335 C C   . VAL A 1 293 ? 5.552   35.137  28.460 1.00 22.31  ? 316 VAL A C   1 ? 
ATOM   2336 O O   . VAL A 1 293 ? 5.999   35.092  29.611 1.00 20.35  ? 316 VAL A O   1 ? 
ATOM   2337 C CB  . VAL A 1 293 ? 6.312   33.318  26.804 1.00 27.95  ? 316 VAL A CB  1 ? 
ATOM   2338 C CG1 . VAL A 1 293 ? 5.986   31.949  26.227 1.00 18.05  ? 316 VAL A CG1 1 ? 
ATOM   2339 C CG2 . VAL A 1 293 ? 6.612   34.307  25.688 1.00 28.66  ? 316 VAL A CG2 1 ? 
ATOM   2340 N N   . GLY A 1 294 ? 5.316   36.262  27.794 1.00 21.73  ? 317 GLY A N   1 ? 
ATOM   2341 C CA  . GLY A 1 294 ? 5.559   37.559  28.438 1.00 19.68  ? 317 GLY A CA  1 ? 
ATOM   2342 C C   . GLY A 1 294 ? 6.875   38.176  28.021 1.00 21.64  ? 317 GLY A C   1 ? 
ATOM   2343 O O   . GLY A 1 294 ? 7.797   37.444  27.679 1.00 23.96  ? 317 GLY A O   1 ? 
ATOM   2344 N N   . ALA A 1 295 ? 6.956   39.499  28.089 1.00 19.99  ? 318 ALA A N   1 ? 
ATOM   2345 C CA  . ALA A 1 295 ? 8.179   40.207  27.663 1.00 23.82  ? 318 ALA A CA  1 ? 
ATOM   2346 C C   . ALA A 1 295 ? 9.394   39.793  28.491 1.00 22.29  ? 318 ALA A C   1 ? 
ATOM   2347 O O   . ALA A 1 295 ? 10.461  39.676  27.912 1.00 23.67  ? 318 ALA A O   1 ? 
ATOM   2348 C CB  . ALA A 1 295 ? 7.964   41.699  27.791 1.00 21.81  ? 318 ALA A CB  1 ? 
ATOM   2349 N N   . ASP A 1 296 ? 9.218   39.626  29.801 1.00 18.21  ? 319 ASP A N   1 ? 
ATOM   2350 C CA  . ASP A 1 296 ? 10.370  39.359  30.699 1.00 17.00  ? 319 ASP A CA  1 ? 
ATOM   2351 C C   . ASP A 1 296 ? 11.043  38.024  30.364 1.00 18.39  ? 319 ASP A C   1 ? 
ATOM   2352 O O   . ASP A 1 296 ? 12.258  37.981  30.280 1.00 19.01  ? 319 ASP A O   1 ? 
ATOM   2353 C CB  . ASP A 1 296 ? 9.968   39.463  32.158 1.00 16.90  ? 319 ASP A CB  1 ? 
ATOM   2354 C CG  . ASP A 1 296 ? 11.092  39.116  33.117 1.00 19.11  ? 319 ASP A CG  1 ? 
ATOM   2355 O OD1 . ASP A 1 296 ? 12.021  39.930  33.235 1.00 16.51  ? 319 ASP A OD1 1 ? 
ATOM   2356 O OD2 . ASP A 1 296 ? 11.044  38.020  33.695 1.00 20.79  ? 319 ASP A OD2 1 ? 
ATOM   2357 N N   . LEU A 1 297 ? 10.246  36.976  30.209 1.00 16.01  ? 320 LEU A N   1 ? 
ATOM   2358 C CA  . LEU A 1 297 ? 10.815  35.648  29.890 1.00 17.49  ? 320 LEU A CA  1 ? 
ATOM   2359 C C   . LEU A 1 297 ? 11.512  35.720  28.523 1.00 17.70  ? 320 LEU A C   1 ? 
ATOM   2360 O O   . LEU A 1 297 ? 12.595  35.175  28.374 1.00 15.94  ? 320 LEU A O   1 ? 
ATOM   2361 C CB  . LEU A 1 297 ? 9.705   34.605  29.883 1.00 17.39  ? 320 LEU A CB  1 ? 
ATOM   2362 C CG  . LEU A 1 297 ? 9.168   34.154  31.239 1.00 17.85  ? 320 LEU A CG  1 ? 
ATOM   2363 C CD1 . LEU A 1 297 ? 8.331   32.914  31.018 1.00 18.74  ? 320 LEU A CD1 1 ? 
ATOM   2364 C CD2 . LEU A 1 297 ? 10.324  33.849  32.158 1.00 23.24  ? 320 LEU A CD2 1 ? 
ATOM   2365 N N   . LEU A 1 298 ? 10.859  36.379  27.577 1.00 18.90  ? 321 LEU A N   1 ? 
ATOM   2366 C CA  . LEU A 1 298 ? 11.431  36.490  26.218 1.00 19.10  ? 321 LEU A CA  1 ? 
ATOM   2367 C C   . LEU A 1 298 ? 12.738  37.295  26.307 1.00 23.18  ? 321 LEU A C   1 ? 
ATOM   2368 O O   . LEU A 1 298 ? 13.732  36.877  25.729 1.00 25.19  ? 321 LEU A O   1 ? 
ATOM   2369 C CB  . LEU A 1 298 ? 10.362  37.102  25.321 1.00 18.74  ? 321 LEU A CB  1 ? 
ATOM   2370 C CG  . LEU A 1 298 ? 10.498  36.827  23.823 1.00 34.24  ? 321 LEU A CG  1 ? 
ATOM   2371 C CD1 . LEU A 1 298 ? 10.565  35.337  23.576 1.00 32.32  ? 321 LEU A CD1 1 ? 
ATOM   2372 C CD2 . LEU A 1 298 ? 9.326   37.446  23.082 1.00 33.17  ? 321 LEU A CD2 1 ? 
ATOM   2373 N N   . GLN A 1 299 ? 12.740  38.381  27.070 1.00 21.30  ? 322 GLN A N   1 ? 
ATOM   2374 C CA  . GLN A 1 299 ? 13.992  39.160  27.276 1.00 23.94  ? 322 GLN A CA  1 ? 
ATOM   2375 C C   . GLN A 1 299 ? 15.084  38.270  27.915 1.00 24.47  ? 322 GLN A C   1 ? 
ATOM   2376 O O   . GLN A 1 299 ? 16.206  38.242  27.411 1.00 19.82  ? 322 GLN A O   1 ? 
ATOM   2377 C CB  . GLN A 1 299 ? 13.713  40.415  28.090 1.00 22.69  ? 322 GLN A CB  1 ? 
ATOM   2378 C CG  . GLN A 1 299 ? 14.930  41.315  28.256 1.00 40.34  ? 322 GLN A CG  1 ? 
ATOM   2379 C CD  . GLN A 1 299 ? 14.940  42.060  29.571 1.00 61.49  ? 322 GLN A CD  1 ? 
ATOM   2380 O OE1 . GLN A 1 299 ? 14.148  42.981  29.794 1.00 62.64  ? 322 GLN A OE1 1 ? 
ATOM   2381 N NE2 . GLN A 1 299 ? 15.843  41.663  30.455 1.00 72.34  ? 322 GLN A NE2 1 ? 
ATOM   2382 N N   . ALA A 1 300 ? 14.729  37.544  28.965 1.00 21.12  ? 323 ALA A N   1 ? 
ATOM   2383 C CA  . ALA A 1 300 ? 15.709  36.674  29.642 1.00 19.47  ? 323 ALA A CA  1 ? 
ATOM   2384 C C   . ALA A 1 300 ? 16.227  35.586  28.691 1.00 24.57  ? 323 ALA A C   1 ? 
ATOM   2385 O O   . ALA A 1 300 ? 17.411  35.238  28.737 1.00 24.30  ? 323 ALA A O   1 ? 
ATOM   2386 C CB  . ALA A 1 300 ? 15.083  36.098  30.872 1.00 18.47  ? 323 ALA A CB  1 ? 
ATOM   2387 N N   . ALA A 1 301 ? 15.348  35.041  27.867 1.00 18.87  ? 324 ALA A N   1 ? 
ATOM   2388 C CA  . ALA A 1 301 ? 15.759  33.956  26.946 1.00 22.35  ? 324 ALA A CA  1 ? 
ATOM   2389 C C   . ALA A 1 301 ? 16.700  34.520  25.882 1.00 25.50  ? 324 ALA A C   1 ? 
ATOM   2390 O O   . ALA A 1 301 ? 17.742  33.924  25.604 1.00 25.44  ? 324 ALA A O   1 ? 
ATOM   2391 C CB  . ALA A 1 301 ? 14.541  33.319  26.335 1.00 18.53  ? 324 ALA A CB  1 ? 
ATOM   2392 N N   . GLU A 1 302 ? 16.321  35.657  25.301 1.00 23.04  ? 325 GLU A N   1 ? 
ATOM   2393 C CA  . GLU A 1 302 ? 17.199  36.323  24.306 1.00 26.82  ? 325 GLU A CA  1 ? 
ATOM   2394 C C   . GLU A 1 302 ? 18.554  36.703  24.950 1.00 26.93  ? 325 GLU A C   1 ? 
ATOM   2395 O O   . GLU A 1 302 ? 19.577  36.558  24.297 1.00 24.74  ? 325 GLU A O   1 ? 
ATOM   2396 C CB  . GLU A 1 302 ? 16.497  37.553  23.734 1.00 24.46  ? 325 GLU A CB  1 ? 
ATOM   2397 C CG  . GLU A 1 302 ? 15.246  37.226  22.929 1.00 36.37  ? 325 GLU A CG  1 ? 
ATOM   2398 C CD  . GLU A 1 302 ? 15.435  37.488  21.450 1.00 47.06  ? 325 GLU A CD  1 ? 
ATOM   2399 O OE1 . GLU A 1 302 ? 16.406  36.947  20.894 1.00 67.00  ? 325 GLU A OE1 1 ? 
ATOM   2400 O OE2 . GLU A 1 302 ? 14.627  38.229  20.863 1.00 48.61  ? 325 GLU A OE2 1 ? 
ATOM   2401 N N   . ALA A 1 303 ? 18.539  37.133  26.208 1.00 20.26  ? 326 ALA A N   1 ? 
ATOM   2402 C CA  . ALA A 1 303 ? 19.786  37.527  26.896 1.00 20.70  ? 326 ALA A CA  1 ? 
ATOM   2403 C C   . ALA A 1 303 ? 20.687  36.315  27.133 1.00 25.50  ? 326 ALA A C   1 ? 
ATOM   2404 O O   . ALA A 1 303 ? 21.878  36.494  27.369 1.00 22.37  ? 326 ALA A O   1 ? 
ATOM   2405 C CB  . ALA A 1 303 ? 19.434  38.199  28.196 1.00 22.55  ? 326 ALA A CB  1 ? 
ATOM   2406 N N   . SER A 1 304 ? 20.109  35.124  27.085 1.00 23.01  ? 327 SER A N   1 ? 
ATOM   2407 C CA  . SER A 1 304 ? 20.861  33.878  27.371 1.00 20.45  ? 327 SER A CA  1 ? 
ATOM   2408 C C   . SER A 1 304 ? 21.815  33.549  26.223 1.00 21.10  ? 327 SER A C   1 ? 
ATOM   2409 O O   . SER A 1 304 ? 22.675  32.690  26.416 1.00 21.67  ? 327 SER A O   1 ? 
ATOM   2410 C CB  . SER A 1 304 ? 19.903  32.758  27.600 1.00 25.65  ? 327 SER A CB  1 ? 
ATOM   2411 O OG  . SER A 1 304 ? 19.416  32.225  26.380 1.00 33.16  ? 327 SER A OG  1 ? 
ATOM   2412 N N   . ASN A 1 305 ? 21.663  34.232  25.093 1.00 24.53  ? 328 ASN A N   1 ? 
ATOM   2413 C CA  . ASN A 1 305 ? 22.488  33.982  23.885 1.00 28.14  ? 328 ASN A CA  1 ? 
ATOM   2414 C C   . ASN A 1 305 ? 23.782  34.773  24.037 1.00 33.41  ? 328 ASN A C   1 ? 
ATOM   2415 O O   . ASN A 1 305 ? 24.718  34.568  23.266 1.00 31.26  ? 328 ASN A O   1 ? 
ATOM   2416 C CB  . ASN A 1 305 ? 21.699  34.373  22.651 1.00 24.22  ? 328 ASN A CB  1 ? 
ATOM   2417 C CG  . ASN A 1 305 ? 20.629  33.364  22.314 1.00 23.95  ? 328 ASN A CG  1 ? 
ATOM   2418 O OD1 . ASN A 1 305 ? 20.891  32.160  22.312 1.00 21.43  ? 328 ASN A OD1 1 ? 
ATOM   2419 N ND2 . ASN A 1 305 ? 19.425  33.833  22.029 1.00 23.59  ? 328 ASN A ND2 1 ? 
ATOM   2420 N N   . ARG A 1 306 ? 23.768  35.707  24.975 1.00 31.34  ? 329 ARG A N   1 ? 
ATOM   2421 C CA  . ARG A 1 306 ? 25.000  36.448  25.281 1.00 46.15  ? 329 ARG A CA  1 ? 
ATOM   2422 C C   . ARG A 1 306 ? 25.610  35.766  26.497 1.00 53.00  ? 329 ARG A C   1 ? 
ATOM   2423 O O   . ARG A 1 306 ? 24.953  35.709  27.553 1.00 63.57  ? 329 ARG A O   1 ? 
ATOM   2424 C CB  . ARG A 1 306 ? 24.701  37.926  25.542 1.00 47.31  ? 329 ARG A CB  1 ? 
ATOM   2425 C CG  . ARG A 1 306 ? 23.276  38.334  25.201 1.00 82.51  ? 329 ARG A CG  1 ? 
ATOM   2426 C CD  . ARG A 1 306 ? 23.184  39.699  24.548 1.00 83.19  ? 329 ARG A CD  1 ? 
ATOM   2427 N NE  . ARG A 1 306 ? 22.797  40.722  25.524 1.00 78.98  ? 329 ARG A NE  1 ? 
ATOM   2428 C CZ  . ARG A 1 306 ? 21.579  40.873  26.021 1.00 79.82  ? 329 ARG A CZ  1 ? 
ATOM   2429 N NH1 . ARG A 1 306 ? 20.520  40.761  25.237 1.00 71.96  ? 329 ARG A NH1 1 ? 
ATOM   2430 N NH2 . ARG A 1 306 ? 21.429  41.144  27.305 1.00 70.75  ? 329 ARG A NH2 1 ? 
ATOM   2431 N N   . PRO A 1 307 ? 26.785  35.150  26.370 1.00 77.08  ? 330 PRO A N   1 ? 
ATOM   2432 C CA  . PRO A 1 307 ? 27.445  34.611  27.535 1.00 92.82  ? 330 PRO A CA  1 ? 
ATOM   2433 C C   . PRO A 1 307 ? 27.701  35.824  28.410 1.00 91.66  ? 330 PRO A C   1 ? 
ATOM   2434 O O   . PRO A 1 307 ? 28.479  36.669  27.929 1.00 99.75  ? 330 PRO A O   1 ? 
ATOM   2435 C CB  . PRO A 1 307 ? 28.718  34.015  26.941 1.00 79.81  ? 330 PRO A CB  1 ? 
ATOM   2436 C CG  . PRO A 1 307 ? 28.365  33.747  25.500 1.00 72.88  ? 330 PRO A CG  1 ? 
ATOM   2437 C CD  . PRO A 1 307 ? 27.487  34.924  25.122 1.00 76.54  ? 330 PRO A CD  1 ? 
ATOM   2438 N N   . PRO B 1 3   ? -6.778  -12.003 57.141 1.00 28.28  ? 26  PRO B N   1 ? 
ATOM   2439 C CA  . PRO B 1 3   ? -5.951  -12.272 55.967 1.00 30.26  ? 26  PRO B CA  1 ? 
ATOM   2440 C C   . PRO B 1 3   ? -6.709  -12.118 54.651 1.00 24.01  ? 26  PRO B C   1 ? 
ATOM   2441 O O   . PRO B 1 3   ? -7.801  -12.671 54.510 1.00 27.38  ? 26  PRO B O   1 ? 
ATOM   2442 C CB  . PRO B 1 3   ? -5.460  -13.721 56.154 1.00 27.90  ? 26  PRO B CB  1 ? 
ATOM   2443 C CG  . PRO B 1 3   ? -6.100  -14.185 57.434 1.00 30.50  ? 26  PRO B CG  1 ? 
ATOM   2444 C CD  . PRO B 1 3   ? -7.263  -13.248 57.685 1.00 30.57  ? 26  PRO B CD  1 ? 
ATOM   2445 N N   . ILE B 1 4   ? -6.132  -11.391 53.704 1.00 21.72  ? 27  ILE B N   1 ? 
ATOM   2446 C CA  . ILE B 1 4   ? -6.780  -11.287 52.364 1.00 18.57  ? 27  ILE B CA  1 ? 
ATOM   2447 C C   . ILE B 1 4   ? -6.491  -12.581 51.589 1.00 16.47  ? 27  ILE B C   1 ? 
ATOM   2448 O O   . ILE B 1 4   ? -5.329  -12.967 51.515 1.00 18.51  ? 27  ILE B O   1 ? 
ATOM   2449 C CB  . ILE B 1 4   ? -6.318  -10.047 51.591 1.00 18.37  ? 27  ILE B CB  1 ? 
ATOM   2450 C CG1 . ILE B 1 4   ? -6.679  -8.771  52.329 1.00 22.13  ? 27  ILE B CG1 1 ? 
ATOM   2451 C CG2 . ILE B 1 4   ? -6.884  -10.059 50.173 1.00 21.65  ? 27  ILE B CG2 1 ? 
ATOM   2452 C CD1 . ILE B 1 4   ? -5.844  -7.574  51.926 1.00 24.91  ? 27  ILE B CD1 1 ? 
ATOM   2453 N N   . VAL B 1 5   ? -7.536  -13.204 51.055 1.00 16.87  ? 28  VAL B N   1 ? 
ATOM   2454 C CA  . VAL B 1 5   ? -7.398  -14.485 50.322 1.00 17.99  ? 28  VAL B CA  1 ? 
ATOM   2455 C C   . VAL B 1 5   ? -7.380  -14.261 48.800 1.00 17.76  ? 28  VAL B C   1 ? 
ATOM   2456 O O   . VAL B 1 5   ? -8.262  -13.576 48.288 1.00 17.23  ? 28  VAL B O   1 ? 
ATOM   2457 C CB  . VAL B 1 5   ? -8.501  -15.483 50.725 1.00 17.32  ? 28  VAL B CB  1 ? 
ATOM   2458 C CG1 . VAL B 1 5   ? -8.583  -16.674 49.780 1.00 18.45  ? 28  VAL B CG1 1 ? 
ATOM   2459 C CG2 . VAL B 1 5   ? -8.322  -15.952 52.161 1.00 18.29  ? 28  VAL B CG2 1 ? 
ATOM   2460 N N   . ILE B 1 6   ? -6.394  -14.850 48.132 1.00 18.16  ? 29  ILE B N   1 ? 
ATOM   2461 C CA  . ILE B 1 6   ? -6.341  -14.820 46.647 1.00 15.24  ? 29  ILE B CA  1 ? 
ATOM   2462 C C   . ILE B 1 6   ? -6.327  -16.271 46.167 1.00 17.64  ? 29  ILE B C   1 ? 
ATOM   2463 O O   . ILE B 1 6   ? -5.294  -16.923 46.312 1.00 20.06  ? 29  ILE B O   1 ? 
ATOM   2464 C CB  . ILE B 1 6   ? -5.125  -14.063 46.096 1.00 19.33  ? 29  ILE B CB  1 ? 
ATOM   2465 C CG1 . ILE B 1 6   ? -5.132  -12.605 46.533 1.00 20.72  ? 29  ILE B CG1 1 ? 
ATOM   2466 C CG2 . ILE B 1 6   ? -5.057  -14.185 44.575 1.00 17.11  ? 29  ILE B CG2 1 ? 
ATOM   2467 C CD1 . ILE B 1 6   ? -3.993  -11.793 45.954 1.00 23.78  ? 29  ILE B CD1 1 ? 
ATOM   2468 N N   . LYS B 1 7   ? -7.473  -16.746 45.708 1.00 16.42  ? 30  LYS B N   1 ? 
ATOM   2469 C CA  . LYS B 1 7   ? -7.506  -18.092 45.100 1.00 17.95  ? 30  LYS B CA  1 ? 
ATOM   2470 C C   . LYS B 1 7   ? -7.123  -17.893 43.628 1.00 17.75  ? 30  LYS B C   1 ? 
ATOM   2471 O O   . LYS B 1 7   ? -7.715  -17.033 42.963 1.00 16.83  ? 30  LYS B O   1 ? 
ATOM   2472 C CB  . LYS B 1 7   ? -8.823  -18.829 45.363 1.00 19.91  ? 30  LYS B CB  1 ? 
ATOM   2473 C CG  . LYS B 1 7   ? -9.010  -19.366 46.762 1.00 17.69  ? 30  LYS B CG  1 ? 
ATOM   2474 C CD  . LYS B 1 7   ? -10.449 -19.811 46.968 1.00 21.95  ? 30  LYS B CD  1 ? 
ATOM   2475 C CE  . LYS B 1 7   ? -11.391 -18.658 46.977 1.00 17.16  ? 30  LYS B CE  1 ? 
ATOM   2476 N NZ  . LYS B 1 7   ? -12.564 -18.956 47.796 1.00 20.79  ? 30  LYS B NZ  1 ? 
ATOM   2477 N N   . PHE B 1 8   ? -6.117  -18.632 43.190 1.00 18.48  ? 31  PHE B N   1 ? 
ATOM   2478 C CA  . PHE B 1 8   ? -5.637  -18.552 41.797 1.00 15.77  ? 31  PHE B CA  1 ? 
ATOM   2479 C C   . PHE B 1 8   ? -5.931  -19.893 41.174 1.00 15.67  ? 31  PHE B C   1 ? 
ATOM   2480 O O   . PHE B 1 8   ? -5.275  -20.877 41.517 1.00 19.74  ? 31  PHE B O   1 ? 
ATOM   2481 C CB  . PHE B 1 8   ? -4.153  -18.178 41.799 1.00 15.90  ? 31  PHE B CB  1 ? 
ATOM   2482 C CG  . PHE B 1 8   ? -3.526  -17.806 40.464 1.00 18.37  ? 31  PHE B CG  1 ? 
ATOM   2483 C CD1 . PHE B 1 8   ? -4.118  -18.160 39.259 1.00 15.81  ? 31  PHE B CD1 1 ? 
ATOM   2484 C CD2 . PHE B 1 8   ? -2.328  -17.106 40.422 1.00 16.17  ? 31  PHE B CD2 1 ? 
ATOM   2485 C CE1 . PHE B 1 8   ? -3.530  -17.820 38.056 1.00 18.10  ? 31  PHE B CE1 1 ? 
ATOM   2486 C CE2 . PHE B 1 8   ? -1.746  -16.769 39.213 1.00 15.74  ? 31  PHE B CE2 1 ? 
ATOM   2487 C CZ  . PHE B 1 8   ? -2.348  -17.125 38.035 1.00 17.96  ? 31  PHE B CZ  1 ? 
ATOM   2488 N N   . SER B 1 9   ? -6.875  -19.903 40.253 1.00 16.41  ? 32  SER B N   1 ? 
ATOM   2489 C CA  . SER B 1 9   ? -7.296  -21.161 39.605 1.00 18.48  ? 32  SER B CA  1 ? 
ATOM   2490 C C   . SER B 1 9   ? -6.789  -21.195 38.161 1.00 17.62  ? 32  SER B C   1 ? 
ATOM   2491 O O   . SER B 1 9   ? -6.755  -20.150 37.526 1.00 12.95  ? 32  SER B O   1 ? 
ATOM   2492 C CB  . SER B 1 9   ? -8.823  -21.347 39.646 1.00 16.35  ? 32  SER B CB  1 ? 
ATOM   2493 O OG  . SER B 1 9   ? -9.251  -22.477 38.912 1.00 22.22  ? 32  SER B OG  1 ? 
ATOM   2494 N N   . HIS B 1 10  ? -6.440  -22.388 37.699 1.00 15.05  ? 33  HIS B N   1 ? 
ATOM   2495 C CA  . HIS B 1 10  ? -6.060  -22.542 36.278 1.00 14.97  ? 33  HIS B CA  1 ? 
ATOM   2496 C C   . HIS B 1 10  ? -6.316  -23.988 35.828 1.00 16.25  ? 33  HIS B C   1 ? 
ATOM   2497 O O   . HIS B 1 10  ? -6.558  -24.863 36.662 1.00 15.23  ? 33  HIS B O   1 ? 
ATOM   2498 C CB  . HIS B 1 10  ? -4.637  -22.036 36.036 1.00 15.61  ? 33  HIS B CB  1 ? 
ATOM   2499 C CG  . HIS B 1 10  ? -3.571  -22.828 36.703 1.00 16.47  ? 33  HIS B CG  1 ? 
ATOM   2500 N ND1 . HIS B 1 10  ? -3.067  -23.992 36.172 1.00 15.61  ? 33  HIS B ND1 1 ? 
ATOM   2501 C CD2 . HIS B 1 10  ? -2.912  -22.622 37.841 1.00 14.92  ? 33  HIS B CD2 1 ? 
ATOM   2502 C CE1 . HIS B 1 10  ? -2.130  -24.458 36.974 1.00 14.73  ? 33  HIS B CE1 1 ? 
ATOM   2503 N NE2 . HIS B 1 10  ? -2.023  -23.645 37.994 1.00 16.37  ? 33  HIS B NE2 1 ? 
ATOM   2504 N N   . VAL B 1 11  ? -6.211  -24.209 34.526 1.00 16.52  ? 34  VAL B N   1 ? 
ATOM   2505 C CA  . VAL B 1 11  ? -6.575  -25.534 33.955 1.00 17.10  ? 34  VAL B CA  1 ? 
ATOM   2506 C C   . VAL B 1 11  ? -5.340  -26.347 33.527 1.00 19.68  ? 34  VAL B C   1 ? 
ATOM   2507 O O   . VAL B 1 11  ? -5.520  -27.437 33.002 1.00 16.84  ? 34  VAL B O   1 ? 
ATOM   2508 C CB  . VAL B 1 11  ? -7.483  -25.230 32.756 1.00 18.48  ? 34  VAL B CB  1 ? 
ATOM   2509 C CG1 . VAL B 1 11  ? -8.710  -24.417 33.148 1.00 13.02  ? 34  VAL B CG1 1 ? 
ATOM   2510 C CG2 . VAL B 1 11  ? -6.720  -24.559 31.621 1.00 20.22  ? 34  VAL B CG2 1 ? 
ATOM   2511 N N   . VAL B 1 12  ? -4.148  -25.817 33.758 1.00 17.11  ? 35  VAL B N   1 ? 
ATOM   2512 C CA  . VAL B 1 12  ? -2.940  -26.525 33.249 1.00 17.03  ? 35  VAL B CA  1 ? 
ATOM   2513 C C   . VAL B 1 12  ? -2.270  -27.348 34.361 1.00 16.83  ? 35  VAL B C   1 ? 
ATOM   2514 O O   . VAL B 1 12  ? -2.593  -27.160 35.529 1.00 20.21  ? 35  VAL B O   1 ? 
ATOM   2515 C CB  . VAL B 1 12  ? -1.928  -25.588 32.561 1.00 17.09  ? 35  VAL B CB  1 ? 
ATOM   2516 C CG1 . VAL B 1 12  ? -2.524  -24.882 31.359 1.00 17.67  ? 35  VAL B CG1 1 ? 
ATOM   2517 C CG2 . VAL B 1 12  ? -1.289  -24.608 33.530 1.00 16.43  ? 35  VAL B CG2 1 ? 
ATOM   2518 N N   . ALA B 1 13  ? -1.373  -28.242 33.962 1.00 15.53  ? 36  ALA B N   1 ? 
ATOM   2519 C CA  . ALA B 1 13  ? -0.588  -28.995 34.962 1.00 16.67  ? 36  ALA B CA  1 ? 
ATOM   2520 C C   . ALA B 1 13  ? 0.366   -28.068 35.715 1.00 14.28  ? 36  ALA B C   1 ? 
ATOM   2521 O O   . ALA B 1 13  ? 0.604   -26.959 35.296 1.00 15.61  ? 36  ALA B O   1 ? 
ATOM   2522 C CB  . ALA B 1 13  ? 0.195   -30.089 34.303 1.00 16.31  ? 36  ALA B CB  1 ? 
ATOM   2523 N N   . GLU B 1 14  ? 0.912   -28.580 36.806 1.00 17.08  ? 37  GLU B N   1 ? 
ATOM   2524 C CA  . GLU B 1 14  ? 1.833   -27.770 37.639 1.00 18.76  ? 37  GLU B CA  1 ? 
ATOM   2525 C C   . GLU B 1 14  ? 3.167   -27.583 36.913 1.00 18.85  ? 37  GLU B C   1 ? 
ATOM   2526 O O   . GLU B 1 14  ? 3.756   -26.509 37.045 1.00 20.94  ? 37  GLU B O   1 ? 
ATOM   2527 C CB  . GLU B 1 14  ? 2.040   -28.469 38.981 1.00 21.28  ? 37  GLU B CB  1 ? 
ATOM   2528 C CG  . GLU B 1 14  ? 0.793   -28.545 39.849 1.00 24.31  ? 37  GLU B CG  1 ? 
ATOM   2529 C CD  . GLU B 1 14  ? 1.167   -29.010 41.243 1.00 36.00  ? 37  GLU B CD  1 ? 
ATOM   2530 O OE1 . GLU B 1 14  ? 1.258   -28.156 42.137 1.00 35.92  ? 37  GLU B OE1 1 ? 
ATOM   2531 O OE2 . GLU B 1 14  ? 1.380   -30.221 41.429 1.00 35.75  ? 37  GLU B OE2 1 ? 
ATOM   2532 N N   . ASN B 1 15  ? 3.596   -28.594 36.167 1.00 17.30  ? 38  ASN B N   1 ? 
ATOM   2533 C CA  . ASN B 1 15  ? 4.925   -28.561 35.502 1.00 17.12  ? 38  ASN B CA  1 ? 
ATOM   2534 C C   . ASN B 1 15  ? 4.826   -27.804 34.174 1.00 21.14  ? 38  ASN B C   1 ? 
ATOM   2535 O O   . ASN B 1 15  ? 5.268   -28.338 33.158 1.00 20.35  ? 38  ASN B O   1 ? 
ATOM   2536 C CB  . ASN B 1 15  ? 5.474   -29.978 35.392 1.00 20.35  ? 38  ASN B CB  1 ? 
ATOM   2537 C CG  . ASN B 1 15  ? 4.611   -30.911 34.577 1.00 24.91  ? 38  ASN B CG  1 ? 
ATOM   2538 O OD1 . ASN B 1 15  ? 3.382   -30.819 34.607 1.00 25.31  ? 38  ASN B OD1 1 ? 
ATOM   2539 N ND2 . ASN B 1 15  ? 5.237   -31.823 33.849 1.00 22.07  ? 38  ASN B ND2 1 ? 
ATOM   2540 N N   . THR B 1 16  ? 4.311   -26.582 34.216 1.00 16.51  ? 39  THR B N   1 ? 
ATOM   2541 C CA  . THR B 1 16  ? 4.073   -25.817 32.990 1.00 15.94  ? 39  THR B CA  1 ? 
ATOM   2542 C C   . THR B 1 16  ? 4.420   -24.380 33.282 1.00 16.53  ? 39  THR B C   1 ? 
ATOM   2543 O O   . THR B 1 16  ? 4.493   -24.022 34.452 1.00 16.67  ? 39  THR B O   1 ? 
ATOM   2544 C CB  . THR B 1 16  ? 2.588   -25.930 32.617 1.00 15.83  ? 39  THR B CB  1 ? 
ATOM   2545 O OG1 . THR B 1 16  ? 1.876   -25.382 33.721 1.00 16.32  ? 39  THR B OG1 1 ? 
ATOM   2546 C CG2 . THR B 1 16  ? 2.146   -27.349 32.315 1.00 17.04  ? 39  THR B CG2 1 ? 
ATOM   2547 N N   . PRO B 1 17  ? 4.598   -23.530 32.263 1.00 14.18  ? 40  PRO B N   1 ? 
ATOM   2548 C CA  . PRO B 1 17  ? 4.831   -22.118 32.535 1.00 13.55  ? 40  PRO B CA  1 ? 
ATOM   2549 C C   . PRO B 1 17  ? 3.810   -21.476 33.498 1.00 16.26  ? 40  PRO B C   1 ? 
ATOM   2550 O O   . PRO B 1 17  ? 4.219   -20.801 34.441 1.00 15.25  ? 40  PRO B O   1 ? 
ATOM   2551 C CB  . PRO B 1 17  ? 4.796   -21.487 31.148 1.00 12.04  ? 40  PRO B CB  1 ? 
ATOM   2552 C CG  . PRO B 1 17  ? 5.070   -22.618 30.190 1.00 14.64  ? 40  PRO B CG  1 ? 
ATOM   2553 C CD  . PRO B 1 17  ? 4.603   -23.887 30.861 1.00 13.90  ? 40  PRO B CD  1 ? 
ATOM   2554 N N   . LYS B 1 18  ? 2.514   -21.679 33.240 1.00 16.18  ? 41  LYS B N   1 ? 
ATOM   2555 C CA  . LYS B 1 18  ? 1.463   -21.044 34.080 1.00 12.75  ? 41  LYS B CA  1 ? 
ATOM   2556 C C   . LYS B 1 18  ? 1.421   -21.721 35.462 1.00 12.66  ? 41  LYS B C   1 ? 
ATOM   2557 O O   . LYS B 1 18  ? 1.347   -21.036 36.467 1.00 15.60  ? 41  LYS B O   1 ? 
ATOM   2558 C CB  . LYS B 1 18  ? 0.081   -21.084 33.424 1.00 12.70  ? 41  LYS B CB  1 ? 
ATOM   2559 C CG  . LYS B 1 18  ? -1.059  -20.560 34.280 1.00 13.60  ? 41  LYS B CG  1 ? 
ATOM   2560 C CD  . LYS B 1 18  ? -2.299  -20.218 33.467 1.00 13.63  ? 41  LYS B CD  1 ? 
ATOM   2561 C CE  . LYS B 1 18  ? -2.740  -21.295 32.542 1.00 12.11  ? 41  LYS B CE  1 ? 
ATOM   2562 N NZ  . LYS B 1 18  ? -3.950  -20.911 31.815 1.00 16.25  ? 41  LYS B NZ  1 ? 
ATOM   2563 N N   . GLY B 1 19  ? 1.519   -23.037 35.483 1.00 13.10  ? 42  GLY B N   1 ? 
ATOM   2564 C CA  . GLY B 1 19  ? 1.510   -23.747 36.770 1.00 15.56  ? 42  GLY B CA  1 ? 
ATOM   2565 C C   . GLY B 1 19  ? 2.627   -23.291 37.694 1.00 18.77  ? 42  GLY B C   1 ? 
ATOM   2566 O O   . GLY B 1 19  ? 2.364   -23.097 38.891 1.00 18.20  ? 42  GLY B O   1 ? 
ATOM   2567 N N   . GLN B 1 20  ? 3.835   -23.150 37.148 1.00 19.72  ? 43  GLN B N   1 ? 
ATOM   2568 C CA  . GLN B 1 20  ? 4.991   -22.666 37.936 1.00 18.86  ? 43  GLN B CA  1 ? 
ATOM   2569 C C   . GLN B 1 20  ? 4.784   -21.198 38.337 1.00 15.73  ? 43  GLN B C   1 ? 
ATOM   2570 O O   . GLN B 1 20  ? 5.113   -20.846 39.467 1.00 16.89  ? 43  GLN B O   1 ? 
ATOM   2571 C CB  . GLN B 1 20  ? 6.272   -22.869 37.136 1.00 20.34  ? 43  GLN B CB  1 ? 
ATOM   2572 C CG  . GLN B 1 20  ? 6.590   -24.332 36.858 1.00 22.92  ? 43  GLN B CG  1 ? 
ATOM   2573 C CD  . GLN B 1 20  ? 6.858   -25.106 38.126 1.00 29.90  ? 43  GLN B CD  1 ? 
ATOM   2574 O OE1 . GLN B 1 20  ? 7.859   -24.878 38.813 1.00 45.55  ? 43  GLN B OE1 1 ? 
ATOM   2575 N NE2 . GLN B 1 20  ? 5.959   -26.016 38.463 1.00 33.11  ? 43  GLN B NE2 1 ? 
ATOM   2576 N N   . GLY B 1 21  ? 4.277   -20.383 37.421 1.00 14.09  ? 44  GLY B N   1 ? 
ATOM   2577 C CA  . GLY B 1 21  ? 4.029   -18.971 37.748 1.00 15.13  ? 44  GLY B CA  1 ? 
ATOM   2578 C C   . GLY B 1 21  ? 3.096   -18.795 38.936 1.00 16.38  ? 44  GLY B C   1 ? 
ATOM   2579 O O   . GLY B 1 21  ? 3.418   -18.015 39.840 1.00 15.09  ? 44  GLY B O   1 ? 
ATOM   2580 N N   . ALA B 1 22  ? 1.961   -19.485 38.916 1.00 13.53  ? 45  ALA B N   1 ? 
ATOM   2581 C CA  . ALA B 1 22  ? 0.994   -19.401 40.030 1.00 15.72  ? 45  ALA B CA  1 ? 
ATOM   2582 C C   . ALA B 1 22  ? 1.677   -19.772 41.347 1.00 14.24  ? 45  ALA B C   1 ? 
ATOM   2583 O O   . ALA B 1 22  ? 1.511   -19.081 42.347 1.00 17.15  ? 45  ALA B O   1 ? 
ATOM   2584 C CB  . ALA B 1 22  ? -0.178  -20.303 39.756 1.00 15.66  ? 45  ALA B CB  1 ? 
ATOM   2585 N N   . LEU B 1 23  ? 2.410   -20.873 41.327 1.00 16.04  ? 46  LEU B N   1 ? 
ATOM   2586 C CA  . LEU B 1 23  ? 3.088   -21.345 42.556 1.00 17.07  ? 46  LEU B CA  1 ? 
ATOM   2587 C C   . LEU B 1 23  ? 4.125   -20.312 43.037 1.00 13.97  ? 46  LEU B C   1 ? 
ATOM   2588 O O   . LEU B 1 23  ? 4.178   -20.025 44.231 1.00 17.99  ? 46  LEU B O   1 ? 
ATOM   2589 C CB  . LEU B 1 23  ? 3.704   -22.702 42.246 1.00 13.53  ? 46  LEU B CB  1 ? 
ATOM   2590 C CG  . LEU B 1 23  ? 2.719   -23.872 42.217 1.00 16.86  ? 46  LEU B CG  1 ? 
ATOM   2591 C CD1 . LEU B 1 23  ? 3.376   -25.137 41.708 1.00 16.43  ? 46  LEU B CD1 1 ? 
ATOM   2592 C CD2 . LEU B 1 23  ? 2.107   -24.091 43.584 1.00 21.60  ? 46  LEU B CD2 1 ? 
ATOM   2593 N N   . LEU B 1 24  ? 4.875   -19.742 42.109 1.00 15.65  ? 47  LEU B N   1 ? 
ATOM   2594 C CA  . LEU B 1 24  ? 5.877   -18.712 42.480 1.00 14.28  ? 47  LEU B CA  1 ? 
ATOM   2595 C C   . LEU B 1 24  ? 5.172   -17.492 43.092 1.00 16.05  ? 47  LEU B C   1 ? 
ATOM   2596 O O   . LEU B 1 24  ? 5.641   -16.987 44.108 1.00 16.84  ? 47  LEU B O   1 ? 
ATOM   2597 C CB  . LEU B 1 24  ? 6.726   -18.285 41.292 1.00 14.38  ? 47  LEU B CB  1 ? 
ATOM   2598 C CG  . LEU B 1 24  ? 7.875   -17.328 41.621 1.00 13.23  ? 47  LEU B CG  1 ? 
ATOM   2599 C CD1 . LEU B 1 24  ? 8.764   -17.921 42.698 1.00 18.33  ? 47  LEU B CD1 1 ? 
ATOM   2600 C CD2 . LEU B 1 24  ? 8.682   -16.967 40.393 1.00 11.03  ? 47  LEU B CD2 1 ? 
ATOM   2601 N N   . PHE B 1 25  ? 4.104   -17.037 42.445 1.00 17.58  ? 48  PHE B N   1 ? 
ATOM   2602 C CA  . PHE B 1 25  ? 3.337   -15.879 42.985 1.00 16.05  ? 48  PHE B CA  1 ? 
ATOM   2603 C C   . PHE B 1 25  ? 2.944   -16.178 44.446 1.00 16.76  ? 48  PHE B C   1 ? 
ATOM   2604 O O   . PHE B 1 25  ? 3.170   -15.354 45.327 1.00 15.13  ? 48  PHE B O   1 ? 
ATOM   2605 C CB  . PHE B 1 25  ? 2.145   -15.565 42.076 1.00 15.68  ? 48  PHE B CB  1 ? 
ATOM   2606 C CG  . PHE B 1 25  ? 1.353   -14.344 42.515 1.00 17.02  ? 48  PHE B CG  1 ? 
ATOM   2607 C CD1 . PHE B 1 25  ? 1.895   -13.071 42.400 1.00 16.65  ? 48  PHE B CD1 1 ? 
ATOM   2608 C CD2 . PHE B 1 25  ? 0.081   -14.475 43.055 1.00 15.77  ? 48  PHE B CD2 1 ? 
ATOM   2609 C CE1 . PHE B 1 25  ? 1.182   -11.962 42.813 1.00 13.80  ? 48  PHE B CE1 1 ? 
ATOM   2610 C CE2 . PHE B 1 25  ? -0.625  -13.359 43.468 1.00 18.36  ? 48  PHE B CE2 1 ? 
ATOM   2611 C CZ  . PHE B 1 25  ? -0.077  -12.107 43.338 1.00 15.66  ? 48  PHE B CZ  1 ? 
ATOM   2612 N N   . LYS B 1 26  ? 2.386   -17.365 44.674 1.00 13.52  ? 49  LYS B N   1 ? 
ATOM   2613 C CA  . LYS B 1 26  ? 2.042   -17.757 46.061 1.00 13.86  ? 49  LYS B CA  1 ? 
ATOM   2614 C C   . LYS B 1 26  ? 3.294   -17.625 46.954 1.00 16.69  ? 49  LYS B C   1 ? 
ATOM   2615 O O   . LYS B 1 26  ? 3.226   -16.967 47.990 1.00 16.30  ? 49  LYS B O   1 ? 
ATOM   2616 C CB  . LYS B 1 26  ? 1.513   -19.196 46.072 1.00 13.09  ? 49  LYS B CB  1 ? 
ATOM   2617 C CG  . LYS B 1 26  ? 1.330   -19.807 47.449 1.00 14.39  ? 49  LYS B CG  1 ? 
ATOM   2618 C CD  . LYS B 1 26  ? 0.759   -21.216 47.387 1.00 13.77  ? 49  LYS B CD  1 ? 
ATOM   2619 C CE  . LYS B 1 26  ? 0.845   -21.919 48.701 1.00 13.71  ? 49  LYS B CE  1 ? 
ATOM   2620 N NZ  . LYS B 1 26  ? 0.095   -21.224 49.747 1.00 16.20  ? 49  LYS B NZ  1 ? 
ATOM   2621 N N   . LYS B 1 27  ? 4.410   -18.210 46.524 1.00 16.95  ? 50  LYS B N   1 ? 
ATOM   2622 C CA  . LYS B 1 27  ? 5.629   -18.218 47.380 1.00 19.56  ? 50  LYS B CA  1 ? 
ATOM   2623 C C   . LYS B 1 27  ? 6.096   -16.793 47.699 1.00 15.51  ? 50  LYS B C   1 ? 
ATOM   2624 O O   . LYS B 1 27  ? 6.326   -16.494 48.863 1.00 18.47  ? 50  LYS B O   1 ? 
ATOM   2625 C CB  . LYS B 1 27  ? 6.791   -18.965 46.726 1.00 21.11  ? 50  LYS B CB  1 ? 
ATOM   2626 C CG  . LYS B 1 27  ? 8.036   -19.124 47.567 1.00 22.73  ? 50  LYS B CG  1 ? 
ATOM   2627 C CD  . LYS B 1 27  ? 9.125   -19.865 46.804 1.00 29.80  ? 50  LYS B CD  1 ? 
ATOM   2628 C CE  . LYS B 1 27  ? 9.829   -20.870 47.652 1.00 41.81  ? 50  LYS B CE  1 ? 
ATOM   2629 N NZ  . LYS B 1 27  ? 10.331  -22.005 46.874 1.00 46.42  ? 50  LYS B NZ  1 ? 
ATOM   2630 N N   . LEU B 1 28  ? 6.205   -15.960 46.683 1.00 15.21  ? 51  LEU B N   1 ? 
ATOM   2631 C CA  . LEU B 1 28  ? 6.749   -14.602 46.918 1.00 18.98  ? 51  LEU B CA  1 ? 
ATOM   2632 C C   . LEU B 1 28  ? 5.768   -13.769 47.766 1.00 20.15  ? 51  LEU B C   1 ? 
ATOM   2633 O O   . LEU B 1 28  ? 6.209   -13.029 48.643 1.00 22.02  ? 51  LEU B O   1 ? 
ATOM   2634 C CB  . LEU B 1 28  ? 7.056   -13.961 45.569 1.00 18.73  ? 51  LEU B CB  1 ? 
ATOM   2635 C CG  . LEU B 1 28  ? 8.155   -14.634 44.746 1.00 21.41  ? 51  LEU B CG  1 ? 
ATOM   2636 C CD1 . LEU B 1 28  ? 8.515   -13.769 43.560 1.00 22.58  ? 51  LEU B CD1 1 ? 
ATOM   2637 C CD2 . LEU B 1 28  ? 9.371   -14.873 45.614 1.00 23.85  ? 51  LEU B CD2 1 ? 
ATOM   2638 N N   . VAL B 1 29  ? 4.478   -13.903 47.490 1.00 17.11  ? 52  VAL B N   1 ? 
ATOM   2639 C CA  . VAL B 1 29  ? 3.479   -13.123 48.271 1.00 17.56  ? 52  VAL B CA  1 ? 
ATOM   2640 C C   . VAL B 1 29  ? 3.610   -13.520 49.745 1.00 19.73  ? 52  VAL B C   1 ? 
ATOM   2641 O O   . VAL B 1 29  ? 3.641   -12.636 50.592 1.00 24.24  ? 52  VAL B O   1 ? 
ATOM   2642 C CB  . VAL B 1 29  ? 2.050   -13.333 47.744 1.00 19.17  ? 52  VAL B CB  1 ? 
ATOM   2643 C CG1 . VAL B 1 29  ? 0.992   -12.927 48.762 1.00 19.32  ? 52  VAL B CG1 1 ? 
ATOM   2644 C CG2 . VAL B 1 29  ? 1.841   -12.614 46.422 1.00 19.71  ? 52  VAL B CG2 1 ? 
ATOM   2645 N N   . GLU B 1 30  ? 3.706   -14.815 50.009 1.00 17.34  ? 53  GLU B N   1 ? 
ATOM   2646 C CA  . GLU B 1 30  ? 3.736   -15.274 51.417 1.00 19.06  ? 53  GLU B CA  1 ? 
ATOM   2647 C C   . GLU B 1 30  ? 5.088   -14.937 52.080 1.00 21.80  ? 53  GLU B C   1 ? 
ATOM   2648 O O   . GLU B 1 30  ? 5.126   -14.849 53.305 1.00 25.15  ? 53  GLU B O   1 ? 
ATOM   2649 C CB  . GLU B 1 30  ? 3.280   -16.731 51.418 1.00 19.01  ? 53  GLU B CB  1 ? 
ATOM   2650 C CG  . GLU B 1 30  ? 1.781   -16.821 51.141 1.00 24.78  ? 53  GLU B CG  1 ? 
ATOM   2651 C CD  . GLU B 1 30  ? 1.117   -18.182 51.020 1.00 31.63  ? 53  GLU B CD  1 ? 
ATOM   2652 O OE1 . GLU B 1 30  ? -0.129  -18.211 50.979 1.00 30.15  ? 53  GLU B OE1 1 ? 
ATOM   2653 O OE2 . GLU B 1 30  ? 1.834   -19.196 50.963 1.00 29.20  ? 53  GLU B OE2 1 ? 
ATOM   2654 N N   . GLN B 1 31  ? 6.141   -14.734 51.299 1.00 22.79  ? 54  GLN B N   1 ? 
ATOM   2655 C CA  . GLN B 1 31  ? 7.428   -14.344 51.923 1.00 26.17  ? 54  GLN B CA  1 ? 
ATOM   2656 C C   . GLN B 1 31  ? 7.469   -12.833 52.153 1.00 28.36  ? 54  GLN B C   1 ? 
ATOM   2657 O O   . GLN B 1 31  ? 8.178   -12.416 53.065 1.00 32.15  ? 54  GLN B O   1 ? 
ATOM   2658 C CB  . GLN B 1 31  ? 8.609   -14.719 51.034 1.00 28.78  ? 54  GLN B CB  1 ? 
ATOM   2659 C CG  . GLN B 1 31  ? 8.845   -16.215 50.886 1.00 27.70  ? 54  GLN B CG  1 ? 
ATOM   2660 C CD  . GLN B 1 31  ? 9.945   -16.553 49.903 1.00 36.95  ? 54  GLN B CD  1 ? 
ATOM   2661 O OE1 . GLN B 1 31  ? 10.257  -15.789 48.983 1.00 30.92  ? 54  GLN B OE1 1 ? 
ATOM   2662 N NE2 . GLN B 1 31  ? 10.538  -17.720 50.089 1.00 32.92  ? 54  GLN B NE2 1 ? 
ATOM   2663 N N   . ARG B 1 32  ? 6.708   -12.067 51.381 1.00 21.52  ? 55  ARG B N   1 ? 
ATOM   2664 C CA  . ARG B 1 32  ? 6.853   -10.597 51.454 1.00 22.87  ? 55  ARG B CA  1 ? 
ATOM   2665 C C   . ARG B 1 32  ? 5.662   -9.886  52.111 1.00 24.10  ? 55  ARG B C   1 ? 
ATOM   2666 O O   . ARG B 1 32  ? 5.861   -8.772  52.592 1.00 28.05  ? 55  ARG B O   1 ? 
ATOM   2667 C CB  . ARG B 1 32  ? 7.135   -10.110 50.031 1.00 19.65  ? 55  ARG B CB  1 ? 
ATOM   2668 C CG  . ARG B 1 32  ? 8.413   -10.670 49.430 1.00 25.03  ? 55  ARG B CG  1 ? 
ATOM   2669 C CD  . ARG B 1 32  ? 8.432   -10.510 47.927 1.00 27.58  ? 55  ARG B CD  1 ? 
ATOM   2670 N NE  . ARG B 1 32  ? 9.654   -11.051 47.328 1.00 24.86  ? 55  ARG B NE  1 ? 
ATOM   2671 C CZ  . ARG B 1 32  ? 10.090  -10.725 46.126 1.00 28.58  ? 55  ARG B CZ  1 ? 
ATOM   2672 N NH1 . ARG B 1 32  ? 9.476   -9.786  45.435 1.00 24.59  ? 55  ARG B NH1 1 ? 
ATOM   2673 N NH2 . ARG B 1 32  ? 11.137  -11.344 45.618 1.00 30.96  ? 55  ARG B NH2 1 ? 
ATOM   2674 N N   . LEU B 1 33  ? 4.483   -10.487 52.134 1.00 26.00  ? 56  LEU B N   1 ? 
ATOM   2675 C CA  . LEU B 1 33  ? 3.311   -9.731  52.654 1.00 28.43  ? 56  LEU B CA  1 ? 
ATOM   2676 C C   . LEU B 1 33  ? 3.024   -10.090 54.130 1.00 39.65  ? 56  LEU B C   1 ? 
ATOM   2677 O O   . LEU B 1 33  ? 2.003   -9.639  54.641 1.00 37.73  ? 56  LEU B O   1 ? 
ATOM   2678 C CB  . LEU B 1 33  ? 2.117   -9.933  51.725 1.00 25.59  ? 56  LEU B CB  1 ? 
ATOM   2679 C CG  . LEU B 1 33  ? 1.883   -8.870  50.648 1.00 31.42  ? 56  LEU B CG  1 ? 
ATOM   2680 C CD1 . LEU B 1 33  ? 1.652   -7.507  51.262 1.00 34.30  ? 56  LEU B CD1 1 ? 
ATOM   2681 C CD2 . LEU B 1 33  ? 2.974   -8.818  49.603 1.00 34.01  ? 56  LEU B CD2 1 ? 
ATOM   2682 N N   . GLY B 1 34  ? 3.881   -10.888 54.766 1.00 45.95  ? 57  GLY B N   1 ? 
ATOM   2683 C CA  . GLY B 1 34  ? 3.766   -11.195 56.208 1.00 43.04  ? 57  GLY B CA  1 ? 
ATOM   2684 C C   . GLY B 1 34  ? 2.406   -11.694 56.648 1.00 40.10  ? 57  GLY B C   1 ? 
ATOM   2685 O O   . GLY B 1 34  ? 1.872   -11.147 57.620 1.00 43.24  ? 57  GLY B O   1 ? 
ATOM   2686 N N   . GLY B 1 35  ? 1.874   -12.710 55.976 1.00 37.55  ? 58  GLY B N   1 ? 
ATOM   2687 C CA  . GLY B 1 35  ? 0.574   -13.282 56.366 1.00 34.47  ? 58  GLY B CA  1 ? 
ATOM   2688 C C   . GLY B 1 35  ? -0.616  -12.357 56.116 1.00 39.94  ? 58  GLY B C   1 ? 
ATOM   2689 O O   . GLY B 1 35  ? -1.754  -12.812 56.324 1.00 44.26  ? 58  GLY B O   1 ? 
ATOM   2690 N N   . ARG B 1 36  ? -0.383  -11.128 55.668 1.00 23.22  ? 59  ARG B N   1 ? 
ATOM   2691 C CA  . ARG B 1 36  ? -1.503  -10.216 55.329 1.00 25.37  ? 59  ARG B CA  1 ? 
ATOM   2692 C C   . ARG B 1 36  ? -2.288  -10.745 54.123 1.00 19.79  ? 59  ARG B C   1 ? 
ATOM   2693 O O   . ARG B 1 36  ? -3.452  -10.385 53.959 1.00 23.96  ? 59  ARG B O   1 ? 
ATOM   2694 C CB  . ARG B 1 36  ? -0.962  -8.819  55.042 1.00 25.72  ? 59  ARG B CB  1 ? 
ATOM   2695 C CG  . ARG B 1 36  ? -0.891  -7.967  56.298 1.00 36.96  ? 59  ARG B CG  1 ? 
ATOM   2696 C CD  . ARG B 1 36  ? 0.355   -7.109  56.315 1.00 40.54  ? 59  ARG B CD  1 ? 
ATOM   2697 N NE  . ARG B 1 36  ? 0.695   -6.621  54.976 1.00 41.96  ? 59  ARG B NE  1 ? 
ATOM   2698 C CZ  . ARG B 1 36  ? 0.900   -5.350  54.675 1.00 46.20  ? 59  ARG B CZ  1 ? 
ATOM   2699 N NH1 . ARG B 1 36  ? 2.005   -4.995  54.046 1.00 38.51  ? 59  ARG B NH1 1 ? 
ATOM   2700 N NH2 . ARG B 1 36  ? 0.006   -4.440  55.012 1.00 40.49  ? 59  ARG B NH2 1 ? 
ATOM   2701 N N   . VAL B 1 37  ? -1.639  -11.562 53.314 1.00 19.43  ? 60  VAL B N   1 ? 
ATOM   2702 C CA  . VAL B 1 37  ? -2.298  -12.085 52.093 1.00 17.74  ? 60  VAL B CA  1 ? 
ATOM   2703 C C   . VAL B 1 37  ? -1.982  -13.573 51.968 1.00 16.69  ? 60  VAL B C   1 ? 
ATOM   2704 O O   . VAL B 1 37  ? -0.829  -13.941 52.157 1.00 20.16  ? 60  VAL B O   1 ? 
ATOM   2705 C CB  . VAL B 1 37  ? -1.907  -11.337 50.802 1.00 17.00  ? 60  VAL B CB  1 ? 
ATOM   2706 C CG1 . VAL B 1 37  ? -2.591  -11.919 49.574 1.00 14.84  ? 60  VAL B CG1 1 ? 
ATOM   2707 C CG2 . VAL B 1 37  ? -2.181  -9.844  50.895 1.00 15.17  ? 60  VAL B CG2 1 ? 
ATOM   2708 N N   . GLU B 1 38  ? -2.995  -14.359 51.645 1.00 17.42  ? 61  GLU B N   1 ? 
ATOM   2709 C CA  . GLU B 1 38  ? -2.765  -15.789 51.369 1.00 16.63  ? 61  GLU B CA  1 ? 
ATOM   2710 C C   . GLU B 1 38  ? -3.103  -16.050 49.894 1.00 16.42  ? 61  GLU B C   1 ? 
ATOM   2711 O O   . GLU B 1 38  ? -4.011  -15.415 49.368 1.00 15.71  ? 61  GLU B O   1 ? 
ATOM   2712 C CB  . GLU B 1 38  ? -3.566  -16.719 52.272 1.00 15.61  ? 61  GLU B CB  1 ? 
ATOM   2713 C CG  . GLU B 1 38  ? -3.159  -16.633 53.738 1.00 19.59  ? 61  GLU B CG  1 ? 
ATOM   2714 C CD  . GLU B 1 38  ? -3.955  -17.544 54.652 1.00 27.20  ? 61  GLU B CD  1 ? 
ATOM   2715 O OE1 . GLU B 1 38  ? -4.744  -18.351 54.135 1.00 25.05  ? 61  GLU B OE1 1 ? 
ATOM   2716 O OE2 . GLU B 1 38  ? -3.784  -17.448 55.879 1.00 27.63  ? 61  GLU B OE2 1 ? 
ATOM   2717 N N   . VAL B 1 39  ? -2.351  -16.954 49.287 1.00 15.51  ? 62  VAL B N   1 ? 
ATOM   2718 C CA  . VAL B 1 39  ? -2.617  -17.336 47.878 1.00 15.98  ? 62  VAL B CA  1 ? 
ATOM   2719 C C   . VAL B 1 39  ? -2.843  -18.851 47.870 1.00 19.10  ? 62  VAL B C   1 ? 
ATOM   2720 O O   . VAL B 1 39  ? -1.958  -19.562 48.329 1.00 16.76  ? 62  VAL B O   1 ? 
ATOM   2721 C CB  . VAL B 1 39  ? -1.504  -16.927 46.892 1.00 18.04  ? 62  VAL B CB  1 ? 
ATOM   2722 C CG1 . VAL B 1 39  ? -1.834  -17.338 45.465 1.00 13.88  ? 62  VAL B CG1 1 ? 
ATOM   2723 C CG2 . VAL B 1 39  ? -1.183  -15.444 46.972 1.00 14.04  ? 62  VAL B CG2 1 ? 
ATOM   2724 N N   . ASP B 1 40  ? -4.026  -19.265 47.436 1.00 17.20  ? 63  ASP B N   1 ? 
ATOM   2725 C CA  . ASP B 1 40  ? -4.330  -20.706 47.305 1.00 17.41  ? 63  ASP B CA  1 ? 
ATOM   2726 C C   . ASP B 1 40  ? -4.329  -21.017 45.808 1.00 17.84  ? 63  ASP B C   1 ? 
ATOM   2727 O O   . ASP B 1 40  ? -5.099  -20.396 45.078 1.00 17.16  ? 63  ASP B O   1 ? 
ATOM   2728 C CB  . ASP B 1 40  ? -5.615  -21.053 48.026 1.00 16.73  ? 63  ASP B CB  1 ? 
ATOM   2729 C CG  . ASP B 1 40  ? -5.571  -20.912 49.540 1.00 23.45  ? 63  ASP B CG  1 ? 
ATOM   2730 O OD1 . ASP B 1 40  ? -4.462  -20.799 50.089 1.00 24.66  ? 63  ASP B OD1 1 ? 
ATOM   2731 O OD2 . ASP B 1 40  ? -6.649  -20.917 50.152 1.00 29.62  ? 63  ASP B OD2 1 ? 
ATOM   2732 N N   . VAL B 1 41  ? -3.468  -21.948 45.406 1.00 16.43  ? 64  VAL B N   1 ? 
ATOM   2733 C CA  . VAL B 1 41  ? -3.344  -22.280 43.960 1.00 13.93  ? 64  VAL B CA  1 ? 
ATOM   2734 C C   . VAL B 1 41  ? -4.096  -23.578 43.628 1.00 17.04  ? 64  VAL B C   1 ? 
ATOM   2735 O O   . VAL B 1 41  ? -3.839  -24.580 44.298 1.00 16.85  ? 64  VAL B O   1 ? 
ATOM   2736 C CB  . VAL B 1 41  ? -1.878  -22.346 43.502 1.00 14.54  ? 64  VAL B CB  1 ? 
ATOM   2737 C CG1 . VAL B 1 41  ? -1.764  -22.768 42.044 1.00 14.19  ? 64  VAL B CG1 1 ? 
ATOM   2738 C CG2 . VAL B 1 41  ? -1.171  -21.017 43.734 1.00 16.43  ? 64  VAL B CG2 1 ? 
ATOM   2739 N N   . TYR B 1 42  ? -4.921  -23.541 42.577 1.00 15.08  ? 65  TYR B N   1 ? 
ATOM   2740 C CA  . TYR B 1 42  ? -5.735  -24.711 42.160 1.00 20.78  ? 65  TYR B CA  1 ? 
ATOM   2741 C C   . TYR B 1 42  ? -5.446  -24.997 40.698 1.00 16.03  ? 65  TYR B C   1 ? 
ATOM   2742 O O   . TYR B 1 42  ? -5.983  -24.352 39.802 1.00 21.22  ? 65  TYR B O   1 ? 
ATOM   2743 C CB  . TYR B 1 42  ? -7.238  -24.523 42.371 1.00 15.51  ? 65  TYR B CB  1 ? 
ATOM   2744 C CG  . TYR B 1 42  ? -7.626  -24.493 43.841 1.00 17.12  ? 65  TYR B CG  1 ? 
ATOM   2745 C CD1 . TYR B 1 42  ? -7.921  -25.666 44.521 1.00 19.71  ? 65  TYR B CD1 1 ? 
ATOM   2746 C CD2 . TYR B 1 42  ? -7.686  -23.300 44.546 1.00 15.93  ? 65  TYR B CD2 1 ? 
ATOM   2747 C CE1 . TYR B 1 42  ? -8.271  -25.653 45.858 1.00 19.19  ? 65  TYR B CE1 1 ? 
ATOM   2748 C CE2 . TYR B 1 42  ? -8.037  -23.273 45.883 1.00 18.11  ? 65  TYR B CE2 1 ? 
ATOM   2749 C CZ  . TYR B 1 42  ? -8.329  -24.454 46.541 1.00 18.08  ? 65  TYR B CZ  1 ? 
ATOM   2750 O OH  . TYR B 1 42  ? -8.677  -24.449 47.856 1.00 16.59  ? 65  TYR B OH  1 ? 
ATOM   2751 N N   . PRO B 1 43  ? -4.581  -25.981 40.443 1.00 17.26  ? 66  PRO B N   1 ? 
ATOM   2752 C CA  . PRO B 1 43  ? -4.251  -26.344 39.084 1.00 15.45  ? 66  PRO B CA  1 ? 
ATOM   2753 C C   . PRO B 1 43  ? -5.143  -27.382 38.440 1.00 18.92  ? 66  PRO B C   1 ? 
ATOM   2754 O O   . PRO B 1 43  ? -6.023  -27.917 39.101 1.00 16.18  ? 66  PRO B O   1 ? 
ATOM   2755 C CB  . PRO B 1 43  ? -2.862  -26.924 39.323 1.00 19.11  ? 66  PRO B CB  1 ? 
ATOM   2756 C CG  . PRO B 1 43  ? -3.008  -27.679 40.620 1.00 18.21  ? 66  PRO B CG  1 ? 
ATOM   2757 C CD  . PRO B 1 43  ? -3.888  -26.768 41.450 1.00 16.89  ? 66  PRO B CD  1 ? 
ATOM   2758 N N   . ASN B 1 44  ? -4.905  -27.639 37.159 1.00 17.78  ? 67  ASN B N   1 ? 
ATOM   2759 C CA  . ASN B 1 44  ? -5.595  -28.729 36.427 1.00 21.44  ? 67  ASN B CA  1 ? 
ATOM   2760 C C   . ASN B 1 44  ? -7.117  -28.714 36.620 1.00 18.97  ? 67  ASN B C   1 ? 
ATOM   2761 O O   . ASN B 1 44  ? -7.684  -29.799 36.694 1.00 15.45  ? 67  ASN B O   1 ? 
ATOM   2762 C CB  . ASN B 1 44  ? -4.943  -30.074 36.735 1.00 24.47  ? 67  ASN B CB  1 ? 
ATOM   2763 C CG  . ASN B 1 44  ? -4.194  -30.619 35.546 1.00 38.21  ? 67  ASN B CG  1 ? 
ATOM   2764 O OD1 . ASN B 1 44  ? -4.697  -30.585 34.420 1.00 38.93  ? 67  ASN B OD1 1 ? 
ATOM   2765 N ND2 . ASN B 1 44  ? -2.996  -31.130 35.778 1.00 62.63  ? 67  ASN B ND2 1 ? 
ATOM   2766 N N   . SER B 1 45  ? -7.734  -27.534 36.645 1.00 15.36  ? 68  SER B N   1 ? 
ATOM   2767 C CA  . SER B 1 45  ? -9.216  -27.453 36.706 1.00 16.42  ? 68  SER B CA  1 ? 
ATOM   2768 C C   . SER B 1 45  ? -9.758  -28.042 38.023 1.00 19.26  ? 68  SER B C   1 ? 
ATOM   2769 O O   . SER B 1 45  ? -10.960 -28.294 38.096 1.00 16.24  ? 68  SER B O   1 ? 
ATOM   2770 C CB  . SER B 1 45  ? -9.829  -28.098 35.492 1.00 16.20  ? 68  SER B CB  1 ? 
ATOM   2771 O OG  . SER B 1 45  ? -9.379  -27.502 34.287 1.00 19.54  ? 68  SER B OG  1 ? 
ATOM   2772 N N   . SER B 1 46  ? -8.899  -28.176 39.028 1.00 18.89  ? 69  SER B N   1 ? 
ATOM   2773 C CA  . SER B 1 46  ? -9.276  -28.736 40.349 1.00 17.49  ? 69  SER B CA  1 ? 
ATOM   2774 C C   . SER B 1 46  ? -10.434 -27.948 40.972 1.00 22.40  ? 69  SER B C   1 ? 
ATOM   2775 O O   . SER B 1 46  ? -11.290 -28.570 41.596 1.00 23.02  ? 69  SER B O   1 ? 
ATOM   2776 C CB  . SER B 1 46  ? -8.073  -28.758 41.289 1.00 19.00  ? 69  SER B CB  1 ? 
ATOM   2777 O OG  . SER B 1 46  ? -7.383  -27.525 41.331 1.00 22.23  ? 69  SER B OG  1 ? 
ATOM   2778 N N   . LEU B 1 47  ? -10.412 -26.622 40.830 1.00 18.85  ? 70  LEU B N   1 ? 
ATOM   2779 C CA  . LEU B 1 47  ? -11.464 -25.770 41.431 1.00 16.98  ? 70  LEU B CA  1 ? 
ATOM   2780 C C   . LEU B 1 47  ? -12.464 -25.418 40.334 1.00 16.28  ? 70  LEU B C   1 ? 
ATOM   2781 O O   . LEU B 1 47  ? -13.626 -25.783 40.458 1.00 17.75  ? 70  LEU B O   1 ? 
ATOM   2782 C CB  . LEU B 1 47  ? -10.828 -24.519 42.022 1.00 15.68  ? 70  LEU B CB  1 ? 
ATOM   2783 C CG  . LEU B 1 47  ? -11.704 -23.655 42.931 1.00 15.40  ? 70  LEU B CG  1 ? 
ATOM   2784 C CD1 . LEU B 1 47  ? -11.950 -24.344 44.251 1.00 16.37  ? 70  LEU B CD1 1 ? 
ATOM   2785 C CD2 . LEU B 1 47  ? -11.070 -22.297 43.158 1.00 16.66  ? 70  LEU B CD2 1 ? 
ATOM   2786 N N   . PHE B 1 48  ? -11.975 -24.735 39.300 1.00 16.78  ? 71  PHE B N   1 ? 
ATOM   2787 C CA  . PHE B 1 48  ? -12.834 -24.367 38.152 1.00 18.32  ? 71  PHE B CA  1 ? 
ATOM   2788 C C   . PHE B 1 48  ? -12.107 -24.618 36.834 1.00 20.18  ? 71  PHE B C   1 ? 
ATOM   2789 O O   . PHE B 1 48  ? -10.891 -24.434 36.723 1.00 17.41  ? 71  PHE B O   1 ? 
ATOM   2790 C CB  . PHE B 1 48  ? -13.236 -22.895 38.192 1.00 17.99  ? 71  PHE B CB  1 ? 
ATOM   2791 C CG  . PHE B 1 48  ? -13.937 -22.488 39.478 1.00 16.46  ? 71  PHE B CG  1 ? 
ATOM   2792 C CD1 . PHE B 1 48  ? -15.175 -23.020 39.812 1.00 17.78  ? 71  PHE B CD1 1 ? 
ATOM   2793 C CD2 . PHE B 1 48  ? -13.351 -21.586 40.354 1.00 21.05  ? 71  PHE B CD2 1 ? 
ATOM   2794 C CE1 . PHE B 1 48  ? -15.810 -22.655 40.985 1.00 15.33  ? 71  PHE B CE1 1 ? 
ATOM   2795 C CE2 . PHE B 1 48  ? -13.990 -21.229 41.528 1.00 18.66  ? 71  PHE B CE2 1 ? 
ATOM   2796 C CZ  . PHE B 1 48  ? -15.217 -21.760 41.839 1.00 17.54  ? 71  PHE B CZ  1 ? 
ATOM   2797 N N   . GLY B 1 49  ? -12.890 -25.031 35.848 1.00 16.86  ? 72  GLY B N   1 ? 
ATOM   2798 C CA  . GLY B 1 49  ? -12.317 -25.261 34.528 1.00 17.10  ? 72  GLY B CA  1 ? 
ATOM   2799 C C   . GLY B 1 49  ? -12.677 -24.143 33.572 1.00 15.55  ? 72  GLY B C   1 ? 
ATOM   2800 O O   . GLY B 1 49  ? -13.148 -23.095 34.020 1.00 13.97  ? 72  GLY B O   1 ? 
ATOM   2801 N N   . ASP B 1 50  ? -12.445 -24.392 32.287 1.00 16.14  ? 73  ASP B N   1 ? 
ATOM   2802 C CA  . ASP B 1 50  ? -12.709 -23.377 31.246 1.00 18.02  ? 73  ASP B CA  1 ? 
ATOM   2803 C C   . ASP B 1 50  ? -14.128 -22.813 31.387 1.00 19.86  ? 73  ASP B C   1 ? 
ATOM   2804 O O   . ASP B 1 50  ? -15.051 -23.589 31.654 1.00 19.14  ? 73  ASP B O   1 ? 
ATOM   2805 C CB  . ASP B 1 50  ? -12.458 -23.958 29.862 1.00 15.70  ? 73  ASP B CB  1 ? 
ATOM   2806 C CG  . ASP B 1 50  ? -11.016 -24.019 29.389 1.00 19.24  ? 73  ASP B CG  1 ? 
ATOM   2807 O OD1 . ASP B 1 50  ? -10.160 -23.380 30.024 1.00 20.21  ? 73  ASP B OD1 1 ? 
ATOM   2808 O OD2 . ASP B 1 50  ? -10.773 -24.697 28.374 1.00 20.07  ? 73  ASP B OD2 1 ? 
ATOM   2809 N N   . GLY B 1 51  ? -14.278 -21.512 31.150 1.00 15.95  ? 74  GLY B N   1 ? 
ATOM   2810 C CA  . GLY B 1 51  ? -15.601 -20.874 31.201 1.00 17.76  ? 74  GLY B CA  1 ? 
ATOM   2811 C C   . GLY B 1 51  ? -16.044 -20.630 32.621 1.00 18.16  ? 74  GLY B C   1 ? 
ATOM   2812 O O   . GLY B 1 51  ? -16.153 -19.464 33.000 1.00 20.25  ? 74  GLY B O   1 ? 
ATOM   2813 N N   . LYS B 1 52  ? -16.293 -21.708 33.370 1.00 15.24  ? 75  LYS B N   1 ? 
ATOM   2814 C CA  . LYS B 1 52  ? -16.743 -21.599 34.779 1.00 15.14  ? 75  LYS B CA  1 ? 
ATOM   2815 C C   . LYS B 1 52  ? -15.790 -20.687 35.580 1.00 16.48  ? 75  LYS B C   1 ? 
ATOM   2816 O O   . LYS B 1 52  ? -16.278 -19.876 36.363 1.00 16.68  ? 75  LYS B O   1 ? 
ATOM   2817 C CB  . LYS B 1 52  ? -16.838 -23.001 35.385 1.00 16.14  ? 75  LYS B CB  1 ? 
ATOM   2818 C CG  . LYS B 1 52  ? -17.288 -23.072 36.828 1.00 19.05  ? 75  LYS B CG  1 ? 
ATOM   2819 C CD  . LYS B 1 52  ? -18.766 -22.742 36.954 1.00 21.53  ? 75  LYS B CD  1 ? 
ATOM   2820 C CE  . LYS B 1 52  ? -19.305 -22.948 38.328 1.00 27.00  ? 75  LYS B CE  1 ? 
ATOM   2821 N NZ  . LYS B 1 52  ? -20.755 -22.757 38.342 1.00 29.06  ? 75  LYS B NZ  1 ? 
ATOM   2822 N N   . GLU B 1 53  ? -14.481 -20.805 35.342 1.00 16.84  ? 76  GLU B N   1 ? 
ATOM   2823 C CA  . GLU B 1 53  ? -13.485 -19.963 36.053 1.00 17.04  ? 76  GLU B CA  1 ? 
ATOM   2824 C C   . GLU B 1 53  ? -13.852 -18.467 35.951 1.00 17.42  ? 76  GLU B C   1 ? 
ATOM   2825 O O   . GLU B 1 53  ? -13.738 -17.754 36.946 1.00 17.72  ? 76  GLU B O   1 ? 
ATOM   2826 C CB  . GLU B 1 53  ? -12.088 -20.250 35.510 1.00 15.92  ? 76  GLU B CB  1 ? 
ATOM   2827 C CG  . GLU B 1 53  ? -11.896 -19.969 34.023 1.00 19.34  ? 76  GLU B CG  1 ? 
ATOM   2828 C CD  . GLU B 1 53  ? -10.446 -19.970 33.569 1.00 20.46  ? 76  GLU B CD  1 ? 
ATOM   2829 O OE1 . GLU B 1 53  ? -10.217 -19.728 32.376 1.00 20.34  ? 76  GLU B OE1 1 ? 
ATOM   2830 O OE2 . GLU B 1 53  ? -9.550  -20.221 34.394 1.00 19.73  ? 76  GLU B OE2 1 ? 
ATOM   2831 N N   . MET B 1 54  ? -14.275 -18.026 34.775 1.00 15.19  ? 77  MET B N   1 ? 
ATOM   2832 C CA  . MET B 1 54  ? -14.607 -16.596 34.555 1.00 16.94  ? 77  MET B CA  1 ? 
ATOM   2833 C C   . MET B 1 54  ? -15.898 -16.211 35.294 1.00 14.12  ? 77  MET B C   1 ? 
ATOM   2834 O O   . MET B 1 54  ? -15.976 -15.108 35.816 1.00 16.85  ? 77  MET B O   1 ? 
ATOM   2835 C CB  . MET B 1 54  ? -14.798 -16.327 33.063 1.00 17.65  ? 77  MET B CB  1 ? 
ATOM   2836 C CG  . MET B 1 54  ? -13.547 -16.468 32.230 1.00 25.71  ? 77  MET B CG  1 ? 
ATOM   2837 S SD  . MET B 1 54  ? -12.317 -15.213 32.624 1.00 27.63  ? 77  MET B SD  1 ? 
ATOM   2838 C CE  . MET B 1 54  ? -13.098 -13.665 32.156 1.00 24.27  ? 77  MET B CE  1 ? 
ATOM   2839 N N   . GLU B 1 55  ? -16.873 -17.108 35.291 1.00 17.80  ? 78  GLU B N   1 ? 
ATOM   2840 C CA  . GLU B 1 55  ? -18.118 -16.852 36.044 1.00 16.64  ? 78  GLU B CA  1 ? 
ATOM   2841 C C   . GLU B 1 55  ? -17.754 -16.689 37.528 1.00 16.31  ? 78  GLU B C   1 ? 
ATOM   2842 O O   . GLU B 1 55  ? -18.189 -15.712 38.139 1.00 16.40  ? 78  GLU B O   1 ? 
ATOM   2843 C CB  . GLU B 1 55  ? -19.093 -17.987 35.738 1.00 19.64  ? 78  GLU B CB  1 ? 
ATOM   2844 C CG  . GLU B 1 55  ? -19.448 -18.072 34.257 1.00 17.67  ? 78  GLU B CG  1 ? 
ATOM   2845 C CD  . GLU B 1 55  ? -19.776 -19.458 33.737 1.00 23.14  ? 78  GLU B CD  1 ? 
ATOM   2846 O OE1 . GLU B 1 55  ? -20.063 -20.352 34.546 1.00 19.82  ? 78  GLU B OE1 1 ? 
ATOM   2847 O OE2 . GLU B 1 55  ? -19.743 -19.637 32.509 1.00 26.36  ? 78  GLU B OE2 1 ? 
ATOM   2848 N N   . ALA B 1 56  ? -16.915 -17.585 38.034 1.00 11.96  ? 79  ALA B N   1 ? 
ATOM   2849 C CA  . ALA B 1 56  ? -16.516 -17.543 39.456 1.00 13.79  ? 79  ALA B CA  1 ? 
ATOM   2850 C C   . ALA B 1 56  ? -15.753 -16.254 39.779 1.00 15.47  ? 79  ALA B C   1 ? 
ATOM   2851 O O   . ALA B 1 56  ? -15.948 -15.699 40.852 1.00 19.91  ? 79  ALA B O   1 ? 
ATOM   2852 C CB  . ALA B 1 56  ? -15.691 -18.754 39.769 1.00 12.41  ? 79  ALA B CB  1 ? 
ATOM   2853 N N   . LEU B 1 57  ? -14.908 -15.802 38.855 1.00 15.72  ? 80  LEU B N   1 ? 
ATOM   2854 C CA  . LEU B 1 57  ? -14.138 -14.556 39.089 1.00 14.88  ? 80  LEU B CA  1 ? 
ATOM   2855 C C   . LEU B 1 57  ? -15.117 -13.376 39.180 1.00 16.99  ? 80  LEU B C   1 ? 
ATOM   2856 O O   . LEU B 1 57  ? -14.978 -12.534 40.069 1.00 17.17  ? 80  LEU B O   1 ? 
ATOM   2857 C CB  . LEU B 1 57  ? -13.103 -14.342 37.989 1.00 14.54  ? 80  LEU B CB  1 ? 
ATOM   2858 C CG  . LEU B 1 57  ? -12.243 -13.081 38.091 1.00 13.38  ? 80  LEU B CG  1 ? 
ATOM   2859 C CD1 . LEU B 1 57  ? -11.233 -13.212 39.207 1.00 13.80  ? 80  LEU B CD1 1 ? 
ATOM   2860 C CD2 . LEU B 1 57  ? -11.546 -12.809 36.774 1.00 12.21  ? 80  LEU B CD2 1 ? 
ATOM   2861 N N   . LEU B 1 58  ? -16.080 -13.350 38.274 1.00 18.60  ? 81  LEU B N   1 ? 
ATOM   2862 C CA  . LEU B 1 58  ? -17.062 -12.243 38.264 1.00 19.68  ? 81  LEU B CA  1 ? 
ATOM   2863 C C   . LEU B 1 58  ? -17.915 -12.288 39.541 1.00 17.33  ? 81  LEU B C   1 ? 
ATOM   2864 O O   . LEU B 1 58  ? -18.224 -11.220 40.072 1.00 19.49  ? 81  LEU B O   1 ? 
ATOM   2865 C CB  . LEU B 1 58  ? -17.867 -12.327 36.970 1.00 21.55  ? 81  LEU B CB  1 ? 
ATOM   2866 C CG  . LEU B 1 58  ? -17.149 -11.812 35.722 1.00 21.45  ? 81  LEU B CG  1 ? 
ATOM   2867 C CD1 . LEU B 1 58  ? -17.976 -11.997 34.469 1.00 22.20  ? 81  LEU B CD1 1 ? 
ATOM   2868 C CD2 . LEU B 1 58  ? -16.753 -10.361 35.909 1.00 26.22  ? 81  LEU B CD2 1 ? 
ATOM   2869 N N   . LEU B 1 59  ? -18.203 -13.484 40.039 1.00 16.28  ? 82  LEU B N   1 ? 
ATOM   2870 C CA  . LEU B 1 59  ? -19.052 -13.645 41.247 1.00 17.45  ? 82  LEU B CA  1 ? 
ATOM   2871 C C   . LEU B 1 59  ? -18.225 -13.459 42.530 1.00 20.00  ? 82  LEU B C   1 ? 
ATOM   2872 O O   . LEU B 1 59  ? -18.829 -13.213 43.587 1.00 19.87  ? 82  LEU B O   1 ? 
ATOM   2873 C CB  . LEU B 1 59  ? -19.694 -15.026 41.204 1.00 20.13  ? 82  LEU B CB  1 ? 
ATOM   2874 C CG  . LEU B 1 59  ? -20.911 -15.242 42.105 1.00 21.21  ? 82  LEU B CG  1 ? 
ATOM   2875 C CD1 . LEU B 1 59  ? -21.969 -14.217 41.775 1.00 20.62  ? 82  LEU B CD1 1 ? 
ATOM   2876 C CD2 . LEU B 1 59  ? -21.447 -16.646 41.940 1.00 24.35  ? 82  LEU B CD2 1 ? 
ATOM   2877 N N   . GLY B 1 60  ? -16.913 -13.659 42.445 1.00 20.35  ? 83  GLY B N   1 ? 
ATOM   2878 C CA  . GLY B 1 60  ? -16.033 -13.508 43.616 1.00 23.55  ? 83  GLY B CA  1 ? 
ATOM   2879 C C   . GLY B 1 60  ? -15.725 -14.815 44.317 1.00 24.64  ? 83  GLY B C   1 ? 
ATOM   2880 O O   . GLY B 1 60  ? -15.318 -14.759 45.483 1.00 28.88  ? 83  GLY B O   1 ? 
ATOM   2881 N N   . ASP B 1 61  ? -15.875 -15.940 43.627 1.00 19.33  ? 84  ASP B N   1 ? 
ATOM   2882 C CA  . ASP B 1 61  ? -15.547 -17.275 44.193 1.00 19.19  ? 84  ASP B CA  1 ? 
ATOM   2883 C C   . ASP B 1 61  ? -14.095 -17.623 43.856 1.00 17.41  ? 84  ASP B C   1 ? 
ATOM   2884 O O   . ASP B 1 61  ? -13.621 -18.658 44.310 1.00 18.43  ? 84  ASP B O   1 ? 
ATOM   2885 C CB  . ASP B 1 61  ? -16.549 -18.306 43.722 1.00 23.59  ? 84  ASP B CB  1 ? 
ATOM   2886 C CG  . ASP B 1 61  ? -17.977 -18.056 44.185 1.00 28.38  ? 84  ASP B CG  1 ? 
ATOM   2887 O OD1 . ASP B 1 61  ? -18.147 -17.309 45.162 1.00 34.08  ? 84  ASP B OD1 1 ? 
ATOM   2888 O OD2 . ASP B 1 61  ? -18.900 -18.610 43.567 1.00 29.13  ? 84  ASP B OD2 1 ? 
ATOM   2889 N N   . VAL B 1 62  ? -13.447 -16.777 43.066 1.00 17.56  ? 85  VAL B N   1 ? 
ATOM   2890 C CA  . VAL B 1 62  ? -12.003 -16.921 42.738 1.00 14.82  ? 85  VAL B CA  1 ? 
ATOM   2891 C C   . VAL B 1 62  ? -11.499 -15.482 42.532 1.00 14.23  ? 85  VAL B C   1 ? 
ATOM   2892 O O   . VAL B 1 62  ? -12.315 -14.637 42.209 1.00 14.17  ? 85  VAL B O   1 ? 
ATOM   2893 C CB  . VAL B 1 62  ? -11.739 -17.832 41.525 1.00 15.45  ? 85  VAL B CB  1 ? 
ATOM   2894 C CG1 . VAL B 1 62  ? -12.136 -17.198 40.207 1.00 12.50  ? 85  VAL B CG1 1 ? 
ATOM   2895 C CG2 . VAL B 1 62  ? -10.315 -18.364 41.496 1.00 22.47  ? 85  VAL B CG2 1 ? 
ATOM   2896 N N   . GLN B 1 63  ? -10.209 -15.234 42.741 1.00 13.05  ? 86  GLN B N   1 ? 
ATOM   2897 C CA  . GLN B 1 63  ? -9.707  -13.834 42.712 1.00 15.55  ? 86  GLN B CA  1 ? 
ATOM   2898 C C   . GLN B 1 63  ? -8.627  -13.636 41.639 1.00 14.45  ? 86  GLN B C   1 ? 
ATOM   2899 O O   . GLN B 1 63  ? -8.342  -12.497 41.300 1.00 17.06  ? 86  GLN B O   1 ? 
ATOM   2900 C CB  . GLN B 1 63  ? -9.123  -13.449 44.070 1.00 15.93  ? 86  GLN B CB  1 ? 
ATOM   2901 C CG  . GLN B 1 63  ? -10.147 -13.307 45.190 1.00 17.32  ? 86  GLN B CG  1 ? 
ATOM   2902 C CD  . GLN B 1 63  ? -10.712 -14.624 45.671 1.00 16.17  ? 86  GLN B CD  1 ? 
ATOM   2903 O OE1 . GLN B 1 63  ? -10.006 -15.629 45.777 1.00 17.83  ? 86  GLN B OE1 1 ? 
ATOM   2904 N NE2 . GLN B 1 63  ? -12.005 -14.630 45.951 1.00 19.73  ? 86  GLN B NE2 1 ? 
ATOM   2905 N N   . MET B 1 64  ? -8.055  -14.733 41.156 1.00 13.99  ? 87  MET B N   1 ? 
ATOM   2906 C CA  . MET B 1 64  ? -7.046  -14.588 40.091 1.00 14.48  ? 87  MET B CA  1 ? 
ATOM   2907 C C   . MET B 1 64  ? -7.114  -15.733 39.080 1.00 12.35  ? 87  MET B C   1 ? 
ATOM   2908 O O   . MET B 1 64  ? -7.287  -16.879 39.490 1.00 11.91  ? 87  MET B O   1 ? 
ATOM   2909 C CB  . MET B 1 64  ? -5.634  -14.473 40.676 1.00 15.86  ? 87  MET B CB  1 ? 
ATOM   2910 C CG  . MET B 1 64  ? -4.558  -14.020 39.713 1.00 15.39  ? 87  MET B CG  1 ? 
ATOM   2911 S SD  . MET B 1 64  ? -3.006  -13.666 40.567 1.00 16.08  ? 87  MET B SD  1 ? 
ATOM   2912 C CE  . MET B 1 64  ? -3.410  -12.078 41.305 1.00 14.05  ? 87  MET B CE  1 ? 
ATOM   2913 N N   . LEU B 1 65  ? -7.006  -15.361 37.815 1.00 11.67  ? 88  LEU B N   1 ? 
ATOM   2914 C CA  . LEU B 1 65  ? -6.955  -16.367 36.732 1.00 10.79  ? 88  LEU B CA  1 ? 
ATOM   2915 C C   . LEU B 1 65  ? -5.874  -15.955 35.720 1.00 12.14  ? 88  LEU B C   1 ? 
ATOM   2916 O O   . LEU B 1 65  ? -5.426  -14.820 35.765 1.00 13.91  ? 88  LEU B O   1 ? 
ATOM   2917 C CB  . LEU B 1 65  ? -8.289  -16.531 36.007 1.00 8.53   ? 88  LEU B CB  1 ? 
ATOM   2918 C CG  . LEU B 1 65  ? -9.534  -16.777 36.859 1.00 9.58   ? 88  LEU B CG  1 ? 
ATOM   2919 C CD1 . LEU B 1 65  ? -10.758 -16.630 35.988 1.00 11.41  ? 88  LEU B CD1 1 ? 
ATOM   2920 C CD2 . LEU B 1 65  ? -9.495  -18.146 37.501 1.00 8.54   ? 88  LEU B CD2 1 ? 
ATOM   2921 N N   . ALA B 1 66  ? -5.553  -16.864 34.808 1.00 14.28  ? 89  ALA B N   1 ? 
ATOM   2922 C CA  . ALA B 1 66  ? -4.635  -16.519 33.702 1.00 12.80  ? 89  ALA B CA  1 ? 
ATOM   2923 C C   . ALA B 1 66  ? -5.079  -17.294 32.459 1.00 14.38  ? 89  ALA B C   1 ? 
ATOM   2924 O O   . ALA B 1 66  ? -4.350  -18.163 31.990 1.00 12.87  ? 89  ALA B O   1 ? 
ATOM   2925 C CB  . ALA B 1 66  ? -3.221  -16.807 34.090 1.00 12.64  ? 89  ALA B CB  1 ? 
ATOM   2926 N N   . PRO B 1 67  ? -6.285  -16.997 31.923 1.00 16.84  ? 90  PRO B N   1 ? 
ATOM   2927 C CA  . PRO B 1 67  ? -6.803  -17.710 30.770 1.00 12.92  ? 90  PRO B CA  1 ? 
ATOM   2928 C C   . PRO B 1 67  ? -6.114  -17.410 29.453 1.00 13.17  ? 90  PRO B C   1 ? 
ATOM   2929 O O   . PRO B 1 67  ? -5.621  -16.299 29.263 1.00 14.23  ? 90  PRO B O   1 ? 
ATOM   2930 C CB  . PRO B 1 67  ? -8.298  -17.280 30.729 1.00 12.88  ? 90  PRO B CB  1 ? 
ATOM   2931 C CG  . PRO B 1 67  ? -8.533  -16.576 32.040 1.00 16.90  ? 90  PRO B CG  1 ? 
ATOM   2932 C CD  . PRO B 1 67  ? -7.193  -15.961 32.367 1.00 13.63  ? 90  PRO B CD  1 ? 
ATOM   2933 N N   . SER B 1 68  ? -6.128  -18.391 28.553 1.00 14.38  ? 91  SER B N   1 ? 
ATOM   2934 C CA  . SER B 1 68  ? -5.615  -18.156 27.185 1.00 14.88  ? 91  SER B CA  1 ? 
ATOM   2935 C C   . SER B 1 68  ? -6.341  -16.950 26.582 1.00 16.15  ? 91  SER B C   1 ? 
ATOM   2936 O O   . SER B 1 68  ? -7.530  -16.779 26.847 1.00 15.80  ? 91  SER B O   1 ? 
ATOM   2937 C CB  . SER B 1 68  ? -5.788  -19.352 26.265 1.00 16.67  ? 91  SER B CB  1 ? 
ATOM   2938 O OG  . SER B 1 68  ? -5.674  -18.985 24.902 1.00 14.23  ? 91  SER B OG  1 ? 
ATOM   2939 N N   . LEU B 1 69  ? -5.641  -16.210 25.742 1.00 16.91  ? 92  LEU B N   1 ? 
ATOM   2940 C CA  . LEU B 1 69  ? -6.225  -15.012 25.098 1.00 21.50  ? 92  LEU B CA  1 ? 
ATOM   2941 C C   . LEU B 1 69  ? -7.331  -15.393 24.098 1.00 19.91  ? 92  LEU B C   1 ? 
ATOM   2942 O O   . LEU B 1 69  ? -8.016  -14.493 23.627 1.00 20.75  ? 92  LEU B O   1 ? 
ATOM   2943 C CB  . LEU B 1 69  ? -5.045  -14.280 24.469 1.00 19.35  ? 92  LEU B CB  1 ? 
ATOM   2944 C CG  . LEU B 1 69  ? -4.014  -13.725 25.455 1.00 16.61  ? 92  LEU B CG  1 ? 
ATOM   2945 C CD1 . LEU B 1 69  ? -2.721  -13.340 24.768 1.00 14.87  ? 92  LEU B CD1 1 ? 
ATOM   2946 C CD2 . LEU B 1 69  ? -4.584  -12.553 26.213 1.00 19.20  ? 92  LEU B CD2 1 ? 
ATOM   2947 N N   . ALA B 1 70  ? -7.489  -16.684 23.817 1.00 21.47  ? 93  ALA B N   1 ? 
ATOM   2948 C CA  . ALA B 1 70  ? -8.539  -17.177 22.901 1.00 20.48  ? 93  ALA B CA  1 ? 
ATOM   2949 C C   . ALA B 1 70  ? -9.881  -17.293 23.619 1.00 19.75  ? 93  ALA B C   1 ? 
ATOM   2950 O O   . ALA B 1 70  ? -10.845 -17.672 22.975 1.00 19.76  ? 93  ALA B O   1 ? 
ATOM   2951 C CB  . ALA B 1 70  ? -8.135  -18.542 22.425 1.00 18.08  ? 93  ALA B CB  1 ? 
ATOM   2952 N N   . LYS B 1 71  ? -9.924  -16.991 24.912 1.00 17.32  ? 94  LYS B N   1 ? 
ATOM   2953 C CA  . LYS B 1 71  ? -11.153 -17.269 25.687 1.00 17.16  ? 94  LYS B CA  1 ? 
ATOM   2954 C C   . LYS B 1 71  ? -11.840 -16.014 26.259 1.00 16.43  ? 94  LYS B C   1 ? 
ATOM   2955 O O   . LYS B 1 71  ? -12.516 -16.153 27.269 1.00 17.30  ? 94  LYS B O   1 ? 
ATOM   2956 C CB  . LYS B 1 71  ? -10.699 -18.249 26.773 1.00 17.81  ? 94  LYS B CB  1 ? 
ATOM   2957 C CG  . LYS B 1 71  ? -10.180 -19.581 26.262 1.00 19.74  ? 94  LYS B CG  1 ? 
ATOM   2958 C CD  . LYS B 1 71  ? -9.669  -20.521 27.346 1.00 20.01  ? 94  LYS B CD  1 ? 
ATOM   2959 C CE  . LYS B 1 71  ? -9.162  -21.803 26.770 1.00 18.99  ? 94  LYS B CE  1 ? 
ATOM   2960 N NZ  . LYS B 1 71  ? -8.522  -22.675 27.755 1.00 17.18  ? 94  LYS B NZ  1 ? 
ATOM   2961 N N   . PHE B 1 72  ? -11.715 -14.885 25.570 1.00 16.85  ? 95  PHE B N   1 ? 
ATOM   2962 C CA  . PHE B 1 72  ? -12.301 -13.620 26.069 1.00 18.69  ? 95  PHE B CA  1 ? 
ATOM   2963 C C   . PHE B 1 72  ? -13.369 -13.072 25.090 1.00 19.56  ? 95  PHE B C   1 ? 
ATOM   2964 O O   . PHE B 1 72  ? -13.818 -11.972 25.431 1.00 16.35  ? 95  PHE B O   1 ? 
ATOM   2965 C CB  . PHE B 1 72  ? -11.138 -12.662 26.321 1.00 18.90  ? 95  PHE B CB  1 ? 
ATOM   2966 C CG  . PHE B 1 72  ? -10.233 -12.989 27.499 1.00 16.76  ? 95  PHE B CG  1 ? 
ATOM   2967 C CD1 . PHE B 1 72  ? -10.657 -12.778 28.803 1.00 20.86  ? 95  PHE B CD1 1 ? 
ATOM   2968 C CD2 . PHE B 1 72  ? -8.949  -13.476 27.300 1.00 16.23  ? 95  PHE B CD2 1 ? 
ATOM   2969 C CE1 . PHE B 1 72  ? -9.825  -13.062 29.871 1.00 17.79  ? 95  PHE B CE1 1 ? 
ATOM   2970 C CE2 . PHE B 1 72  ? -8.123  -13.758 28.374 1.00 18.64  ? 95  PHE B CE2 1 ? 
ATOM   2971 C CZ  . PHE B 1 72  ? -8.561  -13.546 29.655 1.00 16.52  ? 95  PHE B CZ  1 ? 
ATOM   2972 N N   A GLU B 1 73  ? -13.824 -13.786 24.162 0.50 18.31  ? 96  GLU B N   1 ? 
ATOM   2973 N N   B GLU B 1 73  ? -13.816 -13.784 24.157 0.50 17.32  ? 96  GLU B N   1 ? 
ATOM   2974 C CA  A GLU B 1 73  ? -14.737 -13.234 23.120 0.50 21.35  ? 96  GLU B CA  1 ? 
ATOM   2975 C CA  B GLU B 1 73  ? -14.744 -13.241 23.125 0.50 19.14  ? 96  GLU B CA  1 ? 
ATOM   2976 C C   A GLU B 1 73  ? -16.088 -12.778 23.713 0.50 22.54  ? 96  GLU B C   1 ? 
ATOM   2977 C C   B GLU B 1 73  ? -16.040 -12.713 23.761 0.50 21.16  ? 96  GLU B C   1 ? 
ATOM   2978 O O   A GLU B 1 73  ? -16.671 -11.831 23.168 0.50 24.84  ? 96  GLU B O   1 ? 
ATOM   2979 O O   B GLU B 1 73  ? -16.706 -11.880 23.132 0.50 22.75  ? 96  GLU B O   1 ? 
ATOM   2980 C CB  A GLU B 1 73  ? -14.967 -14.201 21.955 0.50 21.78  ? 96  GLU B CB  1 ? 
ATOM   2981 C CB  B GLU B 1 73  ? -15.096 -14.271 22.054 0.50 18.42  ? 96  GLU B CB  1 ? 
ATOM   2982 C CG  A GLU B 1 73  ? -16.054 -15.242 22.200 0.50 22.64  ? 96  GLU B CG  1 ? 
ATOM   2983 C CG  B GLU B 1 73  ? -14.150 -14.220 20.860 0.50 16.47  ? 96  GLU B CG  1 ? 
ATOM   2984 C CD  A GLU B 1 73  ? -15.949 -16.438 21.269 0.50 25.54  ? 96  GLU B CD  1 ? 
ATOM   2985 C CD  B GLU B 1 73  ? -14.103 -15.486 20.025 0.50 18.71  ? 96  GLU B CD  1 ? 
ATOM   2986 O OE1 A GLU B 1 73  ? -16.796 -17.346 21.375 0.50 35.38  ? 96  GLU B OE1 1 ? 
ATOM   2987 O OE1 B GLU B 1 73  ? -14.901 -16.407 20.311 0.50 28.09  ? 96  GLU B OE1 1 ? 
ATOM   2988 O OE2 A GLU B 1 73  ? -15.020 -16.463 20.438 0.50 30.77  ? 96  GLU B OE2 1 ? 
ATOM   2989 O OE2 B GLU B 1 73  ? -13.271 -15.544 19.095 0.50 10.75  ? 96  GLU B OE2 1 ? 
ATOM   2990 N N   . GLN B 1 74  ? -16.460 -13.302 24.882 1.00 21.82  ? 97  GLN B N   1 ? 
ATOM   2991 C CA  . GLN B 1 74  ? -17.728 -12.888 25.530 1.00 23.13  ? 97  GLN B CA  1 ? 
ATOM   2992 C C   . GLN B 1 74  ? -17.544 -11.540 26.246 1.00 21.31  ? 97  GLN B C   1 ? 
ATOM   2993 O O   . GLN B 1 74  ? -18.565 -10.957 26.620 1.00 21.57  ? 97  GLN B O   1 ? 
ATOM   2994 C CB  . GLN B 1 74  ? -18.216 -13.940 26.518 1.00 21.32  ? 97  GLN B CB  1 ? 
ATOM   2995 C CG  . GLN B 1 74  ? -18.390 -15.335 25.937 1.00 22.79  ? 97  GLN B CG  1 ? 
ATOM   2996 C CD  . GLN B 1 74  ? -18.404 -16.397 27.014 1.00 29.02  ? 97  GLN B CD  1 ? 
ATOM   2997 O OE1 . GLN B 1 74  ? -17.361 -16.794 27.537 1.00 30.66  ? 97  GLN B OE1 1 ? 
ATOM   2998 N NE2 . GLN B 1 74  ? -19.595 -16.847 27.372 1.00 26.63  ? 97  GLN B NE2 1 ? 
ATOM   2999 N N   . TYR B 1 75  ? -16.307 -11.069 26.407 1.00 18.95  ? 98  TYR B N   1 ? 
ATOM   3000 C CA  . TYR B 1 75  ? -16.026 -9.824  27.175 1.00 18.89  ? 98  TYR B CA  1 ? 
ATOM   3001 C C   . TYR B 1 75  ? -15.532 -8.715  26.244 1.00 22.61  ? 98  TYR B C   1 ? 
ATOM   3002 O O   . TYR B 1 75  ? -15.834 -7.554  26.512 1.00 32.13  ? 98  TYR B O   1 ? 
ATOM   3003 C CB  . TYR B 1 75  ? -15.071 -10.187 28.317 1.00 18.15  ? 98  TYR B CB  1 ? 
ATOM   3004 C CG  . TYR B 1 75  ? -15.506 -11.427 29.078 1.00 20.35  ? 98  TYR B CG  1 ? 
ATOM   3005 C CD1 . TYR B 1 75  ? -16.469 -11.345 30.072 1.00 22.32  ? 98  TYR B CD1 1 ? 
ATOM   3006 C CD2 . TYR B 1 75  ? -14.987 -12.678 28.774 1.00 17.14  ? 98  TYR B CD2 1 ? 
ATOM   3007 C CE1 . TYR B 1 75  ? -16.886 -12.467 30.763 1.00 19.68  ? 98  TYR B CE1 1 ? 
ATOM   3008 C CE2 . TYR B 1 75  ? -15.404 -13.810 29.451 1.00 20.43  ? 98  TYR B CE2 1 ? 
ATOM   3009 C CZ  . TYR B 1 75  ? -16.353 -13.702 30.452 1.00 20.42  ? 98  TYR B CZ  1 ? 
ATOM   3010 O OH  . TYR B 1 75  ? -16.780 -14.795 31.137 1.00 20.46  ? 98  TYR B OH  1 ? 
ATOM   3011 N N   . THR B 1 76  ? -14.763 -9.062  25.226 1.00 21.33  ? 99  THR B N   1 ? 
ATOM   3012 C CA  . THR B 1 76  ? -14.321 -8.096  24.214 1.00 21.76  ? 99  THR B CA  1 ? 
ATOM   3013 C C   . THR B 1 76  ? -14.072 -8.858  22.937 1.00 26.87  ? 99  THR B C   1 ? 
ATOM   3014 O O   . THR B 1 76  ? -13.838 -10.068 23.010 1.00 31.26  ? 99  THR B O   1 ? 
ATOM   3015 C CB  . THR B 1 76  ? -13.054 -7.362  24.646 1.00 24.63  ? 99  THR B CB  1 ? 
ATOM   3016 O OG1 . THR B 1 76  ? -12.703 -6.499  23.572 1.00 24.18  ? 99  THR B OG1 1 ? 
ATOM   3017 C CG2 . THR B 1 76  ? -11.909 -8.312  24.942 1.00 24.27  ? 99  THR B CG2 1 ? 
ATOM   3018 N N   . ARG B 1 77  ? -14.107 -8.167  21.807 1.00 22.04  ? 100 ARG B N   1 ? 
ATOM   3019 C CA  . ARG B 1 77  ? -13.777 -8.815  20.521 1.00 26.80  ? 100 ARG B CA  1 ? 
ATOM   3020 C C   . ARG B 1 77  ? -12.376 -8.366  20.071 1.00 25.62  ? 100 ARG B C   1 ? 
ATOM   3021 O O   . ARG B 1 77  ? -11.929 -8.792  19.006 1.00 34.86  ? 100 ARG B O   1 ? 
ATOM   3022 C CB  . ARG B 1 77  ? -14.854 -8.419  19.518 1.00 36.95  ? 100 ARG B CB  1 ? 
ATOM   3023 C CG  . ARG B 1 77  ? -16.211 -9.019  19.848 1.00 50.40  ? 100 ARG B CG  1 ? 
ATOM   3024 C CD  . ARG B 1 77  ? -16.186 -10.516 19.646 1.00 48.18  ? 100 ARG B CD  1 ? 
ATOM   3025 N NE  . ARG B 1 77  ? -17.535 -11.074 19.530 1.00 69.43  ? 100 ARG B NE  1 ? 
ATOM   3026 C CZ  . ARG B 1 77  ? -17.869 -12.297 19.918 1.00 74.57  ? 100 ARG B CZ  1 ? 
ATOM   3027 N NH1 . ARG B 1 77  ? -17.542 -13.337 19.176 1.00 60.19  ? 100 ARG B NH1 1 ? 
ATOM   3028 N NH2 . ARG B 1 77  ? -18.524 -12.474 21.050 1.00 77.62  ? 100 ARG B NH2 1 ? 
ATOM   3029 N N   . LYS B 1 78  ? -11.716 -7.549  20.875 1.00 19.69  ? 101 LYS B N   1 ? 
ATOM   3030 C CA  . LYS B 1 78  ? -10.392 -7.023  20.462 1.00 22.29  ? 101 LYS B CA  1 ? 
ATOM   3031 C C   . LYS B 1 78  ? -9.279  -8.058  20.720 1.00 22.01  ? 101 LYS B C   1 ? 
ATOM   3032 O O   . LYS B 1 78  ? -8.390  -8.159  19.881 1.00 27.11  ? 101 LYS B O   1 ? 
ATOM   3033 C CB  . LYS B 1 78  ? -10.149 -5.679  21.145 1.00 25.37  ? 101 LYS B CB  1 ? 
ATOM   3034 C CG  . LYS B 1 78  ? -10.797 -4.508  20.431 1.00 32.22  ? 101 LYS B CG  1 ? 
ATOM   3035 C CD  . LYS B 1 78  ? -10.756 -3.227  21.253 1.00 49.54  ? 101 LYS B CD  1 ? 
ATOM   3036 C CE  . LYS B 1 78  ? -11.484 -2.107  20.577 1.00 61.06  ? 101 LYS B CE  1 ? 
ATOM   3037 N NZ  . LYS B 1 78  ? -11.739 -0.965  21.460 1.00 46.38  ? 101 LYS B NZ  1 ? 
ATOM   3038 N N   . VAL B 1 79  ? -9.349  -8.807  21.817 1.00 24.03  ? 102 VAL B N   1 ? 
ATOM   3039 C CA  . VAL B 1 79  ? -8.286  -9.801  22.189 1.00 22.35  ? 102 VAL B CA  1 ? 
ATOM   3040 C C   . VAL B 1 79  ? -8.307  -11.003 21.223 1.00 22.50  ? 102 VAL B C   1 ? 
ATOM   3041 O O   . VAL B 1 79  ? -7.325  -11.749 21.197 1.00 23.06  ? 102 VAL B O   1 ? 
ATOM   3042 C CB  . VAL B 1 79  ? -8.471  -10.161 23.676 1.00 25.92  ? 102 VAL B CB  1 ? 
ATOM   3043 C CG1 . VAL B 1 79  ? -7.516  -11.237 24.169 1.00 21.79  ? 102 VAL B CG1 1 ? 
ATOM   3044 C CG2 . VAL B 1 79  ? -8.369  -8.921  24.555 1.00 19.28  ? 102 VAL B CG2 1 ? 
ATOM   3045 N N   . GLN B 1 80  ? -9.343  -11.124 20.396 1.00 25.08  ? 103 GLN B N   1 ? 
ATOM   3046 C CA  . GLN B 1 80  ? -9.414  -12.174 19.345 1.00 26.52  ? 103 GLN B CA  1 ? 
ATOM   3047 C C   . GLN B 1 80  ? -8.227  -12.067 18.380 1.00 23.32  ? 103 GLN B C   1 ? 
ATOM   3048 O O   . GLN B 1 80  ? -7.953  -13.035 17.676 1.00 27.78  ? 103 GLN B O   1 ? 
ATOM   3049 C CB  . GLN B 1 80  ? -10.582 -11.889 18.408 1.00 32.43  ? 103 GLN B CB  1 ? 
ATOM   3050 C CG  . GLN B 1 80  ? -11.953 -12.315 18.908 1.00 37.34  ? 103 GLN B CG  1 ? 
ATOM   3051 C CD  . GLN B 1 80  ? -13.003 -12.173 17.830 1.00 33.01  ? 103 GLN B CD  1 ? 
ATOM   3052 O OE1 . GLN B 1 80  ? -13.128 -11.123 17.193 1.00 41.09  ? 103 GLN B OE1 1 ? 
ATOM   3053 N NE2 . GLN B 1 80  ? -13.745 -13.240 17.593 1.00 29.75  ? 103 GLN B NE2 1 ? 
ATOM   3054 N N   . ILE B 1 81  ? -7.582  -10.908 18.334 1.00 24.41  ? 104 ILE B N   1 ? 
ATOM   3055 C CA  . ILE B 1 81  ? -6.408  -10.692 17.438 1.00 26.91  ? 104 ILE B CA  1 ? 
ATOM   3056 C C   . ILE B 1 81  ? -5.360  -11.781 17.694 1.00 23.31  ? 104 ILE B C   1 ? 
ATOM   3057 O O   . ILE B 1 81  ? -4.751  -12.239 16.734 1.00 24.62  ? 104 ILE B O   1 ? 
ATOM   3058 C CB  . ILE B 1 81  ? -5.833  -9.283  17.655 1.00 24.41  ? 104 ILE B CB  1 ? 
ATOM   3059 C CG1 . ILE B 1 81  ? -4.847  -8.915  16.551 1.00 28.29  ? 104 ILE B CG1 1 ? 
ATOM   3060 C CG2 . ILE B 1 81  ? -5.215  -9.118  19.044 1.00 22.00  ? 104 ILE B CG2 1 ? 
ATOM   3061 C CD1 . ILE B 1 81  ? -4.819  -7.439  16.215 1.00 31.49  ? 104 ILE B CD1 1 ? 
ATOM   3062 N N   . PHE B 1 82  ? -5.236  -12.223 18.937 1.00 20.68  ? 105 PHE B N   1 ? 
ATOM   3063 C CA  . PHE B 1 82  ? -4.173  -13.190 19.304 1.00 18.66  ? 105 PHE B CA  1 ? 
ATOM   3064 C C   . PHE B 1 82  ? -4.439  -14.549 18.681 1.00 22.60  ? 105 PHE B C   1 ? 
ATOM   3065 O O   . PHE B 1 82  ? -3.527  -15.371 18.685 1.00 25.49  ? 105 PHE B O   1 ? 
ATOM   3066 C CB  . PHE B 1 82  ? -4.082  -13.259 20.825 1.00 16.95  ? 105 PHE B CB  1 ? 
ATOM   3067 C CG  . PHE B 1 82  ? -3.431  -12.041 21.462 1.00 18.91  ? 105 PHE B CG  1 ? 
ATOM   3068 C CD1 . PHE B 1 82  ? -2.059  -11.835 21.370 1.00 21.90  ? 105 PHE B CD1 1 ? 
ATOM   3069 C CD2 . PHE B 1 82  ? -4.189  -11.109 22.158 1.00 19.20  ? 105 PHE B CD2 1 ? 
ATOM   3070 C CE1 . PHE B 1 82  ? -1.468  -10.732 21.960 1.00 19.81  ? 105 PHE B CE1 1 ? 
ATOM   3071 C CE2 . PHE B 1 82  ? -3.592  -10.008 22.744 1.00 18.13  ? 105 PHE B CE2 1 ? 
ATOM   3072 C CZ  . PHE B 1 82  ? -2.235  -9.822  22.643 1.00 19.62  ? 105 PHE B CZ  1 ? 
ATOM   3073 N N   . ASP B 1 83  ? -5.653  -14.769 18.193 1.00 20.50  ? 106 ASP B N   1 ? 
ATOM   3074 C CA  . ASP B 1 83  ? -6.028  -16.080 17.609 1.00 20.41  ? 106 ASP B CA  1 ? 
ATOM   3075 C C   . ASP B 1 83  ? -5.805  -16.104 16.095 1.00 20.62  ? 106 ASP B C   1 ? 
ATOM   3076 O O   . ASP B 1 83  ? -5.814  -17.189 15.518 1.00 22.37  ? 106 ASP B O   1 ? 
ATOM   3077 C CB  . ASP B 1 83  ? -7.468  -16.402 17.944 1.00 27.12  ? 106 ASP B CB  1 ? 
ATOM   3078 C CG  . ASP B 1 83  ? -7.692  -16.904 19.355 1.00 38.28  ? 106 ASP B CG  1 ? 
ATOM   3079 O OD1 . ASP B 1 83  ? -6.685  -17.240 20.009 1.00 38.30  ? 106 ASP B OD1 1 ? 
ATOM   3080 O OD2 . ASP B 1 83  ? -8.864  -16.947 19.767 1.00 31.80  ? 106 ASP B OD2 1 ? 
ATOM   3081 N N   . LEU B 1 84  ? -5.660  -14.934 15.480 1.00 21.95  ? 107 LEU B N   1 ? 
ATOM   3082 C CA  . LEU B 1 84  ? -5.567  -14.925 14.001 1.00 21.59  ? 107 LEU B CA  1 ? 
ATOM   3083 C C   . LEU B 1 84  ? -4.372  -15.795 13.559 1.00 23.51  ? 107 LEU B C   1 ? 
ATOM   3084 O O   . LEU B 1 84  ? -3.253  -15.533 13.991 1.00 23.71  ? 107 LEU B O   1 ? 
ATOM   3085 C CB  . LEU B 1 84  ? -5.494  -13.490 13.487 1.00 20.61  ? 107 LEU B CB  1 ? 
ATOM   3086 C CG  . LEU B 1 84  ? -6.751  -12.644 13.690 1.00 21.24  ? 107 LEU B CG  1 ? 
ATOM   3087 C CD1 . LEU B 1 84  ? -6.519  -11.221 13.222 1.00 27.04  ? 107 LEU B CD1 1 ? 
ATOM   3088 C CD2 . LEU B 1 84  ? -7.933  -13.263 12.979 1.00 20.43  ? 107 LEU B CD2 1 ? 
ATOM   3089 N N   . PRO B 1 85  ? -4.589  -16.808 12.695 1.00 24.87  ? 108 PRO B N   1 ? 
ATOM   3090 C CA  . PRO B 1 85  ? -3.502  -17.663 12.236 1.00 23.65  ? 108 PRO B CA  1 ? 
ATOM   3091 C C   . PRO B 1 85  ? -2.330  -16.982 11.515 1.00 23.72  ? 108 PRO B C   1 ? 
ATOM   3092 O O   . PRO B 1 85  ? -2.575  -16.149 10.648 1.00 24.14  ? 108 PRO B O   1 ? 
ATOM   3093 C CB  . PRO B 1 85  ? -4.228  -18.671 11.338 1.00 26.75  ? 108 PRO B CB  1 ? 
ATOM   3094 C CG  . PRO B 1 85  ? -5.479  -17.961 10.904 1.00 29.44  ? 108 PRO B CG  1 ? 
ATOM   3095 C CD  . PRO B 1 85  ? -5.873  -17.145 12.117 1.00 27.37  ? 108 PRO B CD  1 ? 
ATOM   3096 N N   . PHE B 1 86  ? -1.099  -17.302 11.916 1.00 26.08  ? 109 PHE B N   1 ? 
ATOM   3097 C CA  . PHE B 1 86  ? 0.147   -16.800 11.268 1.00 26.24  ? 109 PHE B CA  1 ? 
ATOM   3098 C C   . PHE B 1 86  ? 0.380   -15.266 11.454 1.00 33.63  ? 109 PHE B C   1 ? 
ATOM   3099 O O   . PHE B 1 86  ? 1.315   -14.760 10.825 1.00 31.36  ? 109 PHE B O   1 ? 
ATOM   3100 C CB  . PHE B 1 86  ? 0.241   -17.264 9.809  1.00 23.30  ? 109 PHE B CB  1 ? 
ATOM   3101 C CG  . PHE B 1 86  ? 0.454   -18.757 9.626  1.00 21.85  ? 109 PHE B CG  1 ? 
ATOM   3102 C CD1 . PHE B 1 86  ? 1.696   -19.333 9.853  1.00 25.91  ? 109 PHE B CD1 1 ? 
ATOM   3103 C CD2 . PHE B 1 86  ? -0.587  -19.580 9.223  1.00 25.83  ? 109 PHE B CD2 1 ? 
ATOM   3104 C CE1 . PHE B 1 86  ? 1.888   -20.692 9.679  1.00 28.55  ? 109 PHE B CE1 1 ? 
ATOM   3105 C CE2 . PHE B 1 86  ? -0.387  -20.937 9.050  1.00 24.50  ? 109 PHE B CE2 1 ? 
ATOM   3106 C CZ  . PHE B 1 86  ? 0.848   -21.489 9.275  1.00 24.97  ? 109 PHE B CZ  1 ? 
ATOM   3107 N N   . LEU B 1 87  ? -0.381  -14.585 12.311 1.00 28.17  ? 110 LEU B N   1 ? 
ATOM   3108 C CA  . LEU B 1 87  ? -0.203  -13.118 12.476 1.00 25.69  ? 110 LEU B CA  1 ? 
ATOM   3109 C C   . LEU B 1 87  ? 1.175   -12.834 13.083 1.00 24.86  ? 110 LEU B C   1 ? 
ATOM   3110 O O   . LEU B 1 87  ? 1.787   -11.835 12.721 1.00 24.55  ? 110 LEU B O   1 ? 
ATOM   3111 C CB  . LEU B 1 87  ? -1.319  -12.530 13.337 1.00 29.84  ? 110 LEU B CB  1 ? 
ATOM   3112 C CG  . LEU B 1 87  ? -1.147  -11.090 13.825 1.00 28.01  ? 110 LEU B CG  1 ? 
ATOM   3113 C CD1 . LEU B 1 87  ? -1.006  -10.109 12.679 1.00 21.52  ? 110 LEU B CD1 1 ? 
ATOM   3114 C CD2 . LEU B 1 87  ? -2.357  -10.752 14.668 1.00 24.77  ? 110 LEU B CD2 1 ? 
ATOM   3115 N N   . PHE B 1 88  ? 1.628   -13.707 13.979 1.00 28.39  ? 111 PHE B N   1 ? 
ATOM   3116 C CA  . PHE B 1 88  ? 2.919   -13.496 14.679 1.00 27.29  ? 111 PHE B CA  1 ? 
ATOM   3117 C C   . PHE B 1 88  ? 3.865   -14.612 14.303 1.00 31.96  ? 111 PHE B C   1 ? 
ATOM   3118 O O   . PHE B 1 88  ? 3.499   -15.792 14.385 1.00 27.44  ? 111 PHE B O   1 ? 
ATOM   3119 C CB  . PHE B 1 88  ? 2.746   -13.453 16.200 1.00 24.78  ? 111 PHE B CB  1 ? 
ATOM   3120 C CG  . PHE B 1 88  ? 1.747   -12.430 16.717 1.00 26.62  ? 111 PHE B CG  1 ? 
ATOM   3121 C CD1 . PHE B 1 88  ? 2.096   -11.091 16.828 1.00 23.75  ? 111 PHE B CD1 1 ? 
ATOM   3122 C CD2 . PHE B 1 88  ? 0.468   -12.812 17.100 1.00 23.86  ? 111 PHE B CD2 1 ? 
ATOM   3123 C CE1 . PHE B 1 88  ? 1.188   -10.166 17.307 1.00 28.70  ? 111 PHE B CE1 1 ? 
ATOM   3124 C CE2 . PHE B 1 88  ? -0.435  -11.881 17.579 1.00 22.91  ? 111 PHE B CE2 1 ? 
ATOM   3125 C CZ  . PHE B 1 88  ? -0.073  -10.562 17.677 1.00 29.28  ? 111 PHE B CZ  1 ? 
ATOM   3126 N N   . ASP B 1 89  ? 5.072   -14.229 13.888 1.00 34.13  ? 112 ASP B N   1 ? 
ATOM   3127 C CA  . ASP B 1 89  ? 6.078   -15.234 13.454 1.00 31.36  ? 112 ASP B CA  1 ? 
ATOM   3128 C C   . ASP B 1 89  ? 6.549   -16.049 14.658 1.00 27.13  ? 112 ASP B C   1 ? 
ATOM   3129 O O   . ASP B 1 89  ? 6.805   -17.243 14.470 1.00 31.71  ? 112 ASP B O   1 ? 
ATOM   3130 C CB  . ASP B 1 89  ? 7.232   -14.576 12.718 1.00 30.68  ? 112 ASP B CB  1 ? 
ATOM   3131 C CG  . ASP B 1 89  ? 6.846   -13.668 11.563 1.00 31.01  ? 112 ASP B CG  1 ? 
ATOM   3132 O OD1 . ASP B 1 89  ? 5.780   -13.900 10.968 1.00 38.35  ? 112 ASP B OD1 1 ? 
ATOM   3133 O OD2 . ASP B 1 89  ? 7.619   -12.740 11.275 1.00 39.45  ? 112 ASP B OD2 1 ? 
ATOM   3134 N N   . ASP B 1 90  ? 6.634   -15.420 15.826 1.00 27.65  ? 113 ASP B N   1 ? 
ATOM   3135 C CA  . ASP B 1 90  ? 7.144   -16.111 17.038 1.00 27.86  ? 113 ASP B CA  1 ? 
ATOM   3136 C C   . ASP B 1 90  ? 6.778   -15.346 18.315 1.00 24.87  ? 113 ASP B C   1 ? 
ATOM   3137 O O   . ASP B 1 90  ? 6.279   -14.232 18.223 1.00 29.12  ? 113 ASP B O   1 ? 
ATOM   3138 C CB  . ASP B 1 90  ? 8.643   -16.324 16.922 1.00 27.23  ? 113 ASP B CB  1 ? 
ATOM   3139 C CG  . ASP B 1 90  ? 9.427   -15.122 16.415 1.00 31.68  ? 113 ASP B CG  1 ? 
ATOM   3140 O OD1 . ASP B 1 90  ? 9.108   -13.995 16.830 1.00 29.28  ? 113 ASP B OD1 1 ? 
ATOM   3141 O OD2 . ASP B 1 90  ? 10.341  -15.324 15.597 1.00 37.90  ? 113 ASP B OD2 1 ? 
ATOM   3142 N N   . ILE B 1 91  ? 7.072   -15.934 19.470 1.00 27.58  ? 114 ILE B N   1 ? 
ATOM   3143 C CA  . ILE B 1 91  ? 6.720   -15.313 20.782 1.00 31.77  ? 114 ILE B CA  1 ? 
ATOM   3144 C C   . ILE B 1 91  ? 7.410   -13.945 20.941 1.00 29.30  ? 114 ILE B C   1 ? 
ATOM   3145 O O   . ILE B 1 91  ? 6.841   -13.065 21.590 1.00 28.41  ? 114 ILE B O   1 ? 
ATOM   3146 C CB  . ILE B 1 91  ? 7.063   -16.295 21.921 1.00 25.56  ? 114 ILE B CB  1 ? 
ATOM   3147 C CG1 . ILE B 1 91  ? 6.098   -17.473 21.936 1.00 30.17  ? 114 ILE B CG1 1 ? 
ATOM   3148 C CG2 . ILE B 1 91  ? 7.099   -15.602 23.280 1.00 27.95  ? 114 ILE B CG2 1 ? 
ATOM   3149 C CD1 . ILE B 1 91  ? 4.684   -17.100 22.340 1.00 28.55  ? 114 ILE B CD1 1 ? 
ATOM   3150 N N   . GLN B 1 92  ? 8.598   -13.782 20.364 1.00 33.58  ? 115 GLN B N   1 ? 
ATOM   3151 C CA  . GLN B 1 92  ? 9.334   -12.491 20.453 1.00 33.73  ? 115 GLN B CA  1 ? 
ATOM   3152 C C   . GLN B 1 92  ? 8.448   -11.400 19.849 1.00 29.90  ? 115 GLN B C   1 ? 
ATOM   3153 O O   . GLN B 1 92  ? 8.318   -10.339 20.459 1.00 32.50  ? 115 GLN B O   1 ? 
ATOM   3154 C CB  . GLN B 1 92  ? 10.699  -12.637 19.781 1.00 40.44  ? 115 GLN B CB  1 ? 
ATOM   3155 C CG  . GLN B 1 92  ? 11.597  -13.676 20.446 1.00 40.07  ? 115 GLN B CG  1 ? 
ATOM   3156 C CD  . GLN B 1 92  ? 11.609  -15.010 19.731 1.00 62.64  ? 115 GLN B CD  1 ? 
ATOM   3157 O OE1 . GLN B 1 92  ? 10.823  -15.914 20.033 1.00 66.40  ? 115 GLN B OE1 1 ? 
ATOM   3158 N NE2 . GLN B 1 92  ? 12.514  -15.147 18.773 1.00 72.38  ? 115 GLN B NE2 1 ? 
ATOM   3159 N N   . ALA B 1 93  ? 7.833   -11.696 18.713 1.00 26.24  ? 116 ALA B N   1 ? 
ATOM   3160 C CA  . ALA B 1 93  ? 6.897   -10.749 18.076 1.00 28.11  ? 116 ALA B CA  1 ? 
ATOM   3161 C C   . ALA B 1 93  ? 5.687   -10.480 18.978 1.00 28.56  ? 116 ALA B C   1 ? 
ATOM   3162 O O   . ALA B 1 93  ? 5.345   -9.317  19.194 1.00 29.66  ? 116 ALA B O   1 ? 
ATOM   3163 C CB  . ALA B 1 93  ? 6.457   -11.362 16.783 1.00 29.55  ? 116 ALA B CB  1 ? 
ATOM   3164 N N   . VAL B 1 94  ? 5.045   -11.549 19.461 1.00 25.62  ? 117 VAL B N   1 ? 
ATOM   3165 C CA  . VAL B 1 94  ? 3.838   -11.409 20.322 1.00 26.33  ? 117 VAL B CA  1 ? 
ATOM   3166 C C   . VAL B 1 94  ? 4.241   -10.538 21.508 1.00 23.76  ? 117 VAL B C   1 ? 
ATOM   3167 O O   . VAL B 1 94  ? 3.455   -9.701  21.923 1.00 24.26  ? 117 VAL B O   1 ? 
ATOM   3168 C CB  . VAL B 1 94  ? 3.340   -12.777 20.824 1.00 35.84  ? 117 VAL B CB  1 ? 
ATOM   3169 C CG1 . VAL B 1 94  ? 1.939   -12.693 21.409 1.00 40.45  ? 117 VAL B CG1 1 ? 
ATOM   3170 C CG2 . VAL B 1 94  ? 3.411   -13.849 19.749 1.00 39.83  ? 117 VAL B CG2 1 ? 
ATOM   3171 N N   . ASP B 1 95  ? 5.448   -10.758 22.000 1.00 24.13  ? 118 ASP B N   1 ? 
ATOM   3172 C CA  . ASP B 1 95  ? 5.913   -10.020 23.193 1.00 27.06  ? 118 ASP B CA  1 ? 
ATOM   3173 C C   . ASP B 1 95  ? 6.002   -8.524  22.865 1.00 26.81  ? 118 ASP B C   1 ? 
ATOM   3174 O O   . ASP B 1 95  ? 5.642   -7.718  23.706 1.00 25.27  ? 118 ASP B O   1 ? 
ATOM   3175 C CB  . ASP B 1 95  ? 7.185   -10.655 23.724 1.00 26.06  ? 118 ASP B CB  1 ? 
ATOM   3176 C CG  . ASP B 1 95  ? 7.741   -10.033 24.990 1.00 28.00  ? 118 ASP B CG  1 ? 
ATOM   3177 O OD1 . ASP B 1 95  ? 7.168   -10.288 26.061 1.00 28.02  ? 118 ASP B OD1 1 ? 
ATOM   3178 O OD2 . ASP B 1 95  ? 8.739   -9.307  24.879 1.00 30.21  ? 118 ASP B OD2 1 ? 
ATOM   3179 N N   . ARG B 1 96  ? 6.451   -8.194  21.660 1.00 29.96  ? 119 ARG B N   1 ? 
ATOM   3180 C CA  . ARG B 1 96  ? 6.610   -6.770  21.269 1.00 30.02  ? 119 ARG B CA  1 ? 
ATOM   3181 C C   . ARG B 1 96  ? 5.228   -6.132  21.142 1.00 26.33  ? 119 ARG B C   1 ? 
ATOM   3182 O O   . ARG B 1 96  ? 5.066   -5.005  21.602 1.00 26.88  ? 119 ARG B O   1 ? 
ATOM   3183 C CB  . ARG B 1 96  ? 7.412   -6.663  19.964 1.00 29.69  ? 119 ARG B CB  1 ? 
ATOM   3184 C CG  . ARG B 1 96  ? 8.875   -7.065  20.073 1.00 29.47  ? 119 ARG B CG  1 ? 
ATOM   3185 C CD  . ARG B 1 96  ? 9.702   -6.648  18.864 1.00 32.49  ? 119 ARG B CD  1 ? 
ATOM   3186 N NE  . ARG B 1 96  ? 9.473   -7.486  17.682 1.00 32.89  ? 119 ARG B NE  1 ? 
ATOM   3187 C CZ  . ARG B 1 96  ? 10.125  -8.604  17.408 1.00 36.24  ? 119 ARG B CZ  1 ? 
ATOM   3188 N NH1 . ARG B 1 96  ? 11.079  -9.030  18.211 1.00 33.71  ? 119 ARG B NH1 1 ? 
ATOM   3189 N NH2 . ARG B 1 96  ? 9.815   -9.300  16.331 1.00 40.06  ? 119 ARG B NH2 1 ? 
ATOM   3190 N N   . PHE B 1 97  ? 4.300   -6.834  20.503 1.00 23.83  ? 120 PHE B N   1 ? 
ATOM   3191 C CA  . PHE B 1 97  ? 2.913   -6.322  20.393 1.00 24.65  ? 120 PHE B CA  1 ? 
ATOM   3192 C C   . PHE B 1 97  ? 2.330   -6.110  21.801 1.00 27.70  ? 120 PHE B C   1 ? 
ATOM   3193 O O   . PHE B 1 97  ? 1.748   -5.069  22.056 1.00 25.69  ? 120 PHE B O   1 ? 
ATOM   3194 C CB  . PHE B 1 97  ? 2.053   -7.281  19.571 1.00 23.38  ? 120 PHE B CB  1 ? 
ATOM   3195 C CG  . PHE B 1 97  ? 0.578   -6.916  19.540 1.00 26.31  ? 120 PHE B CG  1 ? 
ATOM   3196 C CD1 . PHE B 1 97  ? 0.155   -5.715  18.987 1.00 27.56  ? 120 PHE B CD1 1 ? 
ATOM   3197 C CD2 . PHE B 1 97  ? -0.376  -7.767  20.080 1.00 26.84  ? 120 PHE B CD2 1 ? 
ATOM   3198 C CE1 . PHE B 1 97  ? -1.185  -5.382  18.966 1.00 25.44  ? 120 PHE B CE1 1 ? 
ATOM   3199 C CE2 . PHE B 1 97  ? -1.716  -7.427  20.050 1.00 26.21  ? 120 PHE B CE2 1 ? 
ATOM   3200 C CZ  . PHE B 1 97  ? -2.115  -6.240  19.493 1.00 25.71  ? 120 PHE B CZ  1 ? 
ATOM   3201 N N   . GLN B 1 98  ? 2.503   -7.091  22.684 1.00 23.84  ? 121 GLN B N   1 ? 
ATOM   3202 C CA  . GLN B 1 98  ? 1.916   -7.009  24.044 1.00 25.44  ? 121 GLN B CA  1 ? 
ATOM   3203 C C   . GLN B 1 98  ? 2.528   -5.814  24.791 1.00 29.97  ? 121 GLN B C   1 ? 
ATOM   3204 O O   . GLN B 1 98  ? 1.829   -5.209  25.605 1.00 26.75  ? 121 GLN B O   1 ? 
ATOM   3205 C CB  . GLN B 1 98  ? 2.114   -8.335  24.779 1.00 20.64  ? 121 GLN B CB  1 ? 
ATOM   3206 C CG  . GLN B 1 98  ? 1.266   -9.494  24.269 1.00 20.59  ? 121 GLN B CG  1 ? 
ATOM   3207 C CD  . GLN B 1 98  ? 1.752   -10.844 24.752 1.00 24.96  ? 121 GLN B CD  1 ? 
ATOM   3208 O OE1 . GLN B 1 98  ? 2.874   -10.984 25.242 1.00 23.49  ? 121 GLN B OE1 1 ? 
ATOM   3209 N NE2 . GLN B 1 98  ? 0.913   -11.859 24.616 1.00 26.44  ? 121 GLN B NE2 1 ? 
ATOM   3210 N N   . ARG B 1 99  ? 3.782   -5.488  24.479 1.00 27.85  ? 122 ARG B N   1 ? 
ATOM   3211 C CA  . ARG B 1 99  ? 4.484   -4.392  25.191 1.00 30.49  ? 122 ARG B CA  1 ? 
ATOM   3212 C C   . ARG B 1 99  ? 4.148   -3.061  24.517 1.00 29.23  ? 122 ARG B C   1 ? 
ATOM   3213 O O   . ARG B 1 99  ? 4.308   -2.020  25.164 1.00 30.17  ? 122 ARG B O   1 ? 
ATOM   3214 C CB  . ARG B 1 99  ? 5.990   -4.647  25.193 1.00 38.22  ? 122 ARG B CB  1 ? 
ATOM   3215 C CG  . ARG B 1 99  ? 6.415   -5.772  26.124 1.00 45.19  ? 122 ARG B CG  1 ? 
ATOM   3216 C CD  . ARG B 1 99  ? 7.730   -6.377  25.673 1.00 46.83  ? 122 ARG B CD  1 ? 
ATOM   3217 N NE  . ARG B 1 99  ? 8.890   -5.737  26.297 1.00 50.55  ? 122 ARG B NE  1 ? 
ATOM   3218 C CZ  . ARG B 1 99  ? 9.193   -5.837  27.584 1.00 69.62  ? 122 ARG B CZ  1 ? 
ATOM   3219 N NH1 . ARG B 1 99  ? 9.506   -7.011  28.101 1.00 62.74  ? 122 ARG B NH1 1 ? 
ATOM   3220 N NH2 . ARG B 1 99  ? 9.187   -4.760  28.351 1.00 68.92  ? 122 ARG B NH2 1 ? 
ATOM   3221 N N   . SER B 1 100 ? 3.723   -3.119  23.265 1.00 21.86  ? 123 SER B N   1 ? 
ATOM   3222 C CA  . SER B 1 100 ? 3.255   -1.897  22.569 1.00 32.39  ? 123 SER B CA  1 ? 
ATOM   3223 C C   . SER B 1 100 ? 2.141   -1.210  23.371 1.00 29.74  ? 123 SER B C   1 ? 
ATOM   3224 O O   . SER B 1 100 ? 1.346   -1.905  23.997 1.00 25.95  ? 123 SER B O   1 ? 
ATOM   3225 C CB  . SER B 1 100 ? 2.723   -2.234  21.220 1.00 28.00  ? 123 SER B CB  1 ? 
ATOM   3226 O OG  . SER B 1 100 ? 1.389   -2.708  21.315 1.00 29.79  ? 123 SER B OG  1 ? 
ATOM   3227 N N   . PRO B 1 101 ? 2.003   0.127   23.278 1.00 29.34  ? 124 PRO B N   1 ? 
ATOM   3228 C CA  . PRO B 1 101 ? 0.901   0.810   23.947 1.00 26.14  ? 124 PRO B CA  1 ? 
ATOM   3229 C C   . PRO B 1 101 ? -0.467  0.202   23.596 1.00 24.40  ? 124 PRO B C   1 ? 
ATOM   3230 O O   . PRO B 1 101 ? -1.330  0.091   24.460 1.00 22.50  ? 124 PRO B O   1 ? 
ATOM   3231 C CB  . PRO B 1 101 ? 1.084   2.238   23.413 1.00 26.71  ? 124 PRO B CB  1 ? 
ATOM   3232 C CG  . PRO B 1 101 ? 2.561   2.355   23.156 1.00 22.42  ? 124 PRO B CG  1 ? 
ATOM   3233 C CD  . PRO B 1 101 ? 2.910   1.006   22.574 1.00 26.80  ? 124 PRO B CD  1 ? 
ATOM   3234 N N   . GLN B 1 102 ? -0.660  -0.164  22.333 1.00 27.87  ? 125 GLN B N   1 ? 
ATOM   3235 C CA  . GLN B 1 102 ? -1.912  -0.816  21.877 1.00 31.34  ? 125 GLN B CA  1 ? 
ATOM   3236 C C   . GLN B 1 102 ? -2.127  -2.161  22.592 1.00 29.76  ? 125 GLN B C   1 ? 
ATOM   3237 O O   . GLN B 1 102 ? -3.250  -2.440  23.018 1.00 27.19  ? 125 GLN B O   1 ? 
ATOM   3238 C CB  . GLN B 1 102 ? -1.851  -1.086  20.378 1.00 33.59  ? 125 GLN B CB  1 ? 
ATOM   3239 C CG  . GLN B 1 102 ? -2.016  0.156   19.512 1.00 39.16  ? 125 GLN B CG  1 ? 
ATOM   3240 C CD  . GLN B 1 102 ? -0.706  0.646   18.940 1.00 50.24  ? 125 GLN B CD  1 ? 
ATOM   3241 O OE1 . GLN B 1 102 ? 0.352   0.549   19.572 1.00 45.68  ? 125 GLN B OE1 1 ? 
ATOM   3242 N NE2 . GLN B 1 102 ? -0.768  1.173   17.727 1.00 59.79  ? 125 GLN B NE2 1 ? 
ATOM   3243 N N   . GLY B 1 103 ? -1.080  -2.968  22.680 1.00 26.21  ? 126 GLY B N   1 ? 
ATOM   3244 C CA  . GLY B 1 103 ? -1.227  -4.283  23.321 1.00 25.89  ? 126 GLY B CA  1 ? 
ATOM   3245 C C   . GLY B 1 103 ? -1.453  -4.133  24.810 1.00 26.09  ? 126 GLY B C   1 ? 
ATOM   3246 O O   . GLY B 1 103 ? -2.315  -4.830  25.351 1.00 25.11  ? 126 GLY B O   1 ? 
ATOM   3247 N N   . ARG B 1 104 ? -0.703  -3.242  25.442 1.00 22.08  ? 127 ARG B N   1 ? 
ATOM   3248 C CA  . ARG B 1 104 ? -0.855  -2.996  26.895 1.00 26.69  ? 127 ARG B CA  1 ? 
ATOM   3249 C C   . ARG B 1 104 ? -2.281  -2.498  27.178 1.00 22.06  ? 127 ARG B C   1 ? 
ATOM   3250 O O   . ARG B 1 104 ? -2.803  -2.809  28.240 1.00 23.39  ? 127 ARG B O   1 ? 
ATOM   3251 C CB  . ARG B 1 104 ? 0.238   -2.014  27.323 1.00 24.65  ? 127 ARG B CB  1 ? 
ATOM   3252 C CG  . ARG B 1 104 ? 1.417   -2.684  28.011 1.00 34.57  ? 127 ARG B CG  1 ? 
ATOM   3253 C CD  . ARG B 1 104 ? 2.040   -1.838  29.113 1.00 32.52  ? 127 ARG B CD  1 ? 
ATOM   3254 N NE  . ARG B 1 104 ? 1.354   -1.877  30.409 1.00 33.07  ? 127 ARG B NE  1 ? 
ATOM   3255 C CZ  . ARG B 1 104 ? 1.532   -2.805  31.336 1.00 31.52  ? 127 ARG B CZ  1 ? 
ATOM   3256 N NH1 . ARG B 1 104 ? 1.992   -3.994  31.001 1.00 25.86  ? 127 ARG B NH1 1 ? 
ATOM   3257 N NH2 . ARG B 1 104 ? 1.243   -2.547  32.597 1.00 34.38  ? 127 ARG B NH2 1 ? 
ATOM   3258 N N   . ALA B 1 105 ? -2.844  -1.720  26.258 1.00 18.69  ? 128 ALA B N   1 ? 
ATOM   3259 C CA  . ALA B 1 105 ? -4.216  -1.193  26.402 1.00 21.45  ? 128 ALA B CA  1 ? 
ATOM   3260 C C   . ALA B 1 105 ? -5.240  -2.328  26.546 1.00 20.48  ? 128 ALA B C   1 ? 
ATOM   3261 O O   . ALA B 1 105 ? -6.229  -2.168  27.252 1.00 21.12  ? 128 ALA B O   1 ? 
ATOM   3262 C CB  . ALA B 1 105 ? -4.533  -0.343  25.207 1.00 20.36  ? 128 ALA B CB  1 ? 
ATOM   3263 N N   . LEU B 1 106 ? -4.992  -3.458  25.887 1.00 18.10  ? 129 LEU B N   1 ? 
ATOM   3264 C CA  . LEU B 1 106 ? -5.957  -4.582  25.940 1.00 17.59  ? 129 LEU B CA  1 ? 
ATOM   3265 C C   . LEU B 1 106 ? -6.147  -5.081  27.388 1.00 20.05  ? 129 LEU B C   1 ? 
ATOM   3266 O O   . LEU B 1 106 ? -7.159  -5.714  27.656 1.00 19.96  ? 129 LEU B O   1 ? 
ATOM   3267 C CB  . LEU B 1 106 ? -5.498  -5.693  25.005 1.00 17.12  ? 129 LEU B CB  1 ? 
ATOM   3268 C CG  . LEU B 1 106 ? -5.533  -5.343  23.516 1.00 20.80  ? 129 LEU B CG  1 ? 
ATOM   3269 C CD1 . LEU B 1 106 ? -5.177  -6.527  22.641 1.00 20.95  ? 129 LEU B CD1 1 ? 
ATOM   3270 C CD2 . LEU B 1 106 ? -6.889  -4.782  23.153 1.00 17.88  ? 129 LEU B CD2 1 ? 
ATOM   3271 N N   . LEU B 1 107 ? -5.187  -4.826  28.266 1.00 18.28  ? 130 LEU B N   1 ? 
ATOM   3272 C CA  . LEU B 1 107 ? -5.272  -5.341  29.657 1.00 19.26  ? 130 LEU B CA  1 ? 
ATOM   3273 C C   . LEU B 1 107 ? -6.477  -4.714  30.396 1.00 18.24  ? 130 LEU B C   1 ? 
ATOM   3274 O O   . LEU B 1 107 ? -6.930  -5.315  31.366 1.00 17.61  ? 130 LEU B O   1 ? 
ATOM   3275 C CB  . LEU B 1 107 ? -3.958  -5.126  30.397 1.00 18.78  ? 130 LEU B CB  1 ? 
ATOM   3276 C CG  . LEU B 1 107 ? -2.743  -5.895  29.871 1.00 22.24  ? 130 LEU B CG  1 ? 
ATOM   3277 C CD1 . LEU B 1 107 ? -1.475  -5.355  30.501 1.00 25.23  ? 130 LEU B CD1 1 ? 
ATOM   3278 C CD2 . LEU B 1 107 ? -2.876  -7.372  30.153 1.00 16.62  ? 130 LEU B CD2 1 ? 
ATOM   3279 N N   . THR B 1 108 ? -6.944  -3.554  29.948 1.00 20.52  ? 131 THR B N   1 ? 
ATOM   3280 C CA  . THR B 1 108 ? -8.094  -2.851  30.574 1.00 24.58  ? 131 THR B CA  1 ? 
ATOM   3281 C C   . THR B 1 108 ? -9.288  -2.868  29.631 1.00 25.40  ? 131 THR B C   1 ? 
ATOM   3282 O O   . THR B 1 108 ? -10.269 -2.206  29.943 1.00 25.65  ? 131 THR B O   1 ? 
ATOM   3283 C CB  . THR B 1 108 ? -7.664  -1.431  30.935 1.00 28.66  ? 131 THR B CB  1 ? 
ATOM   3284 O OG1 . THR B 1 108 ? -7.138  -0.875  29.736 1.00 32.74  ? 131 THR B OG1 1 ? 
ATOM   3285 C CG2 . THR B 1 108 ? -6.620  -1.395  32.036 1.00 20.45  ? 131 THR B CG2 1 ? 
ATOM   3286 N N   . SER B 1 109 ? -9.235  -3.665  28.562 1.00 22.93  ? 132 SER B N   1 ? 
ATOM   3287 C CA  . SER B 1 109 ? -10.311 -3.758  27.539 1.00 23.27  ? 132 SER B CA  1 ? 
ATOM   3288 C C   . SER B 1 109 ? -11.624 -4.289  28.121 1.00 28.39  ? 132 SER B C   1 ? 
ATOM   3289 O O   . SER B 1 109 ? -12.659 -4.101  27.478 1.00 27.47  ? 132 SER B O   1 ? 
ATOM   3290 C CB  . SER B 1 109 ? -9.879  -4.680  26.433 1.00 20.32  ? 132 SER B CB  1 ? 
ATOM   3291 O OG  . SER B 1 109 ? -9.687  -6.010  26.883 1.00 24.61  ? 132 SER B OG  1 ? 
ATOM   3292 N N   . MET B 1 110 ? -11.569 -4.944  29.268 1.00 24.88  ? 133 MET B N   1 ? 
ATOM   3293 C CA  . MET B 1 110 ? -12.758 -5.619  29.836 1.00 20.96  ? 133 MET B CA  1 ? 
ATOM   3294 C C   . MET B 1 110 ? -13.116 -5.032  31.213 1.00 18.65  ? 133 MET B C   1 ? 
ATOM   3295 O O   . MET B 1 110 ? -13.977 -5.583  31.878 1.00 16.66  ? 133 MET B O   1 ? 
ATOM   3296 C CB  . MET B 1 110 ? -12.416 -7.105  29.941 1.00 22.31  ? 133 MET B CB  1 ? 
ATOM   3297 C CG  . MET B 1 110 ? -12.272 -7.808  28.612 1.00 20.07  ? 133 MET B CG  1 ? 
ATOM   3298 S SD  . MET B 1 110 ? -11.576 -9.459  28.806 1.00 22.89  ? 133 MET B SD  1 ? 
ATOM   3299 C CE  . MET B 1 110 ? -9.850  -9.014  29.035 1.00 23.32  ? 133 MET B CE  1 ? 
ATOM   3300 N N   . GLN B 1 111 ? -12.474 -3.933  31.585 1.00 17.48  ? 134 GLN B N   1 ? 
ATOM   3301 C CA  . GLN B 1 111 ? -12.720 -3.275  32.891 1.00 15.50  ? 134 GLN B CA  1 ? 
ATOM   3302 C C   . GLN B 1 111 ? -14.208 -2.946  33.068 1.00 17.56  ? 134 GLN B C   1 ? 
ATOM   3303 O O   . GLN B 1 111 ? -14.669 -2.949  34.207 1.00 19.46  ? 134 GLN B O   1 ? 
ATOM   3304 C CB  . GLN B 1 111 ? -11.892 -1.992  32.925 1.00 18.29  ? 134 GLN B CB  1 ? 
ATOM   3305 C CG  . GLN B 1 111 ? -11.837 -1.305  34.282 1.00 27.97  ? 134 GLN B CG  1 ? 
ATOM   3306 C CD  . GLN B 1 111 ? -11.024 -0.031  34.249 1.00 43.41  ? 134 GLN B CD  1 ? 
ATOM   3307 O OE1 . GLN B 1 111 ? -10.130 0.137   33.414 1.00 40.33  ? 134 GLN B OE1 1 ? 
ATOM   3308 N NE2 . GLN B 1 111 ? -11.332 0.879   35.159 1.00 31.81  ? 134 GLN B NE2 1 ? 
ATOM   3309 N N   . GLY B 1 112 ? -14.900 -2.630  31.972 1.00 16.15  ? 135 GLY B N   1 ? 
ATOM   3310 C CA  . GLY B 1 112 ? -16.337 -2.303  32.021 1.00 17.36  ? 135 GLY B CA  1 ? 
ATOM   3311 C C   . GLY B 1 112 ? -17.173 -3.522  32.364 1.00 17.75  ? 135 GLY B C   1 ? 
ATOM   3312 O O   . GLY B 1 112 ? -18.312 -3.328  32.788 1.00 21.59  ? 135 GLY B O   1 ? 
ATOM   3313 N N   . LYS B 1 113 ? -16.625 -4.719  32.152 1.00 19.38  ? 136 LYS B N   1 ? 
ATOM   3314 C CA  . LYS B 1 113 ? -17.323 -5.973  32.535 1.00 19.25  ? 136 LYS B CA  1 ? 
ATOM   3315 C C   . LYS B 1 113 ? -16.785 -6.513  33.870 1.00 17.96  ? 136 LYS B C   1 ? 
ATOM   3316 O O   . LYS B 1 113 ? -17.192 -7.598  34.244 1.00 20.93  ? 136 LYS B O   1 ? 
ATOM   3317 C CB  . LYS B 1 113 ? -17.206 -7.024  31.430 1.00 21.64  ? 136 LYS B CB  1 ? 
ATOM   3318 C CG  . LYS B 1 113 ? -17.428 -6.497  30.027 1.00 32.33  ? 136 LYS B CG  1 ? 
ATOM   3319 C CD  . LYS B 1 113 ? -18.366 -7.380  29.218 1.00 33.28  ? 136 LYS B CD  1 ? 
ATOM   3320 C CE  . LYS B 1 113 ? -18.910 -6.691  28.013 1.00 35.00  ? 136 LYS B CE  1 ? 
ATOM   3321 N NZ  . LYS B 1 113 ? -18.697 -5.244  28.070 1.00 38.85  ? 136 LYS B NZ  1 ? 
ATOM   3322 N N   . GLY B 1 114 ? -15.918 -5.769  34.552 1.00 17.73  ? 137 GLY B N   1 ? 
ATOM   3323 C CA  . GLY B 1 114 ? -15.463 -6.178  35.895 1.00 17.89  ? 137 GLY B CA  1 ? 
ATOM   3324 C C   . GLY B 1 114 ? -14.152 -6.951  35.907 1.00 17.11  ? 137 GLY B C   1 ? 
ATOM   3325 O O   . GLY B 1 114 ? -13.762 -7.420  36.986 1.00 22.18  ? 137 GLY B O   1 ? 
ATOM   3326 N N   . ILE B 1 115 ? -13.476 -7.034  34.771 1.00 14.69  ? 138 ILE B N   1 ? 
ATOM   3327 C CA  . ILE B 1 115 ? -12.221 -7.831  34.654 1.00 18.34  ? 138 ILE B CA  1 ? 
ATOM   3328 C C   . ILE B 1 115 ? -11.004 -6.910  34.467 1.00 20.07  ? 138 ILE B C   1 ? 
ATOM   3329 O O   . ILE B 1 115 ? -11.057 -6.042  33.582 1.00 22.66  ? 138 ILE B O   1 ? 
ATOM   3330 C CB  . ILE B 1 115 ? -12.331 -8.834  33.495 1.00 17.53  ? 138 ILE B CB  1 ? 
ATOM   3331 C CG1 . ILE B 1 115 ? -13.453 -9.830  33.734 1.00 23.80  ? 138 ILE B CG1 1 ? 
ATOM   3332 C CG2 . ILE B 1 115 ? -10.999 -9.531  33.238 1.00 19.41  ? 138 ILE B CG2 1 ? 
ATOM   3333 C CD1 . ILE B 1 115 ? -14.269 -10.122 32.493 1.00 29.34  ? 138 ILE B CD1 1 ? 
ATOM   3334 N N   . LEU B 1 116 ? -9.964  -7.131  35.268 1.00 16.66  ? 139 LEU B N   1 ? 
ATOM   3335 C CA  . LEU B 1 116 ? -8.731  -6.320  35.163 1.00 16.99  ? 139 LEU B CA  1 ? 
ATOM   3336 C C   . LEU B 1 116 ? -7.565  -7.224  34.762 1.00 15.74  ? 139 LEU B C   1 ? 
ATOM   3337 O O   . LEU B 1 116 ? -7.321  -8.195  35.466 1.00 16.02  ? 139 LEU B O   1 ? 
ATOM   3338 C CB  . LEU B 1 116 ? -8.395  -5.565  36.448 1.00 18.88  ? 139 LEU B CB  1 ? 
ATOM   3339 C CG  . LEU B 1 116 ? -7.150  -4.680  36.403 1.00 22.90  ? 139 LEU B CG  1 ? 
ATOM   3340 C CD1 . LEU B 1 116 ? -7.271  -3.658  35.290 1.00 20.02  ? 139 LEU B CD1 1 ? 
ATOM   3341 C CD2 . LEU B 1 116 ? -7.002  -4.003  37.750 1.00 22.70  ? 139 LEU B CD2 1 ? 
ATOM   3342 N N   . GLY B 1 117 ? -6.936  -6.913  33.641 1.00 13.65  ? 140 GLY B N   1 ? 
ATOM   3343 C CA  . GLY B 1 117 ? -5.701  -7.614  33.271 1.00 16.47  ? 140 GLY B CA  1 ? 
ATOM   3344 C C   . GLY B 1 117 ? -4.488  -7.031  33.989 1.00 17.99  ? 140 GLY B C   1 ? 
ATOM   3345 O O   . GLY B 1 117 ? -4.336  -5.806  33.977 1.00 16.70  ? 140 GLY B O   1 ? 
ATOM   3346 N N   . LEU B 1 118 ? -3.672  -7.890  34.598 1.00 14.52  ? 141 LEU B N   1 ? 
ATOM   3347 C CA  . LEU B 1 118 ? -2.485  -7.446  35.364 1.00 18.49  ? 141 LEU B CA  1 ? 
ATOM   3348 C C   . LEU B 1 118 ? -1.188  -7.683  34.571 1.00 19.26  ? 141 LEU B C   1 ? 
ATOM   3349 O O   . LEU B 1 118 ? -0.194  -7.010  34.861 1.00 20.25  ? 141 LEU B O   1 ? 
ATOM   3350 C CB  . LEU B 1 118 ? -2.482  -8.233  36.672 1.00 15.98  ? 141 LEU B CB  1 ? 
ATOM   3351 C CG  . LEU B 1 118 ? -3.732  -8.104  37.543 1.00 16.22  ? 141 LEU B CG  1 ? 
ATOM   3352 C CD1 . LEU B 1 118 ? -3.588  -8.975  38.771 1.00 15.08  ? 141 LEU B CD1 1 ? 
ATOM   3353 C CD2 . LEU B 1 118 ? -3.944  -6.657  37.934 1.00 15.72  ? 141 LEU B CD2 1 ? 
ATOM   3354 N N   . ALA B 1 119 ? -1.230  -8.610  33.621 1.00 19.04  ? 142 ALA B N   1 ? 
ATOM   3355 C CA  . ALA B 1 119 ? -0.009  -8.979  32.885 1.00 17.92  ? 142 ALA B CA  1 ? 
ATOM   3356 C C   . ALA B 1 119 ? -0.284  -9.982  31.775 1.00 20.26  ? 142 ALA B C   1 ? 
ATOM   3357 O O   . ALA B 1 119 ? -1.359  -10.592 31.749 1.00 17.76  ? 142 ALA B O   1 ? 
ATOM   3358 C CB  . ALA B 1 119 ? 0.964   -9.621  33.834 1.00 17.80  ? 142 ALA B CB  1 ? 
ATOM   3359 N N   . TYR B 1 120 ? 0.682   -10.087 30.870 1.00 19.04  ? 143 TYR B N   1 ? 
ATOM   3360 C CA  . TYR B 1 120 ? 0.635   -11.137 29.840 1.00 19.83  ? 143 TYR B CA  1 ? 
ATOM   3361 C C   . TYR B 1 120 ? 1.684   -12.167 30.238 1.00 20.19  ? 143 TYR B C   1 ? 
ATOM   3362 O O   . TYR B 1 120 ? 2.789   -11.767 30.622 1.00 16.12  ? 143 TYR B O   1 ? 
ATOM   3363 C CB  . TYR B 1 120 ? 1.002   -10.579 28.470 1.00 20.69  ? 143 TYR B CB  1 ? 
ATOM   3364 C CG  . TYR B 1 120 ? -0.038  -9.749  27.741 1.00 19.65  ? 143 TYR B CG  1 ? 
ATOM   3365 C CD1 . TYR B 1 120 ? -1.174  -10.334 27.201 1.00 15.58  ? 143 TYR B CD1 1 ? 
ATOM   3366 C CD2 . TYR B 1 120 ? 0.146   -8.386  27.559 1.00 17.24  ? 143 TYR B CD2 1 ? 
ATOM   3367 C CE1 . TYR B 1 120 ? -2.102  -9.581  26.505 1.00 14.89  ? 143 TYR B CE1 1 ? 
ATOM   3368 C CE2 . TYR B 1 120 ? -0.774  -7.625  26.864 1.00 18.26  ? 143 TYR B CE2 1 ? 
ATOM   3369 C CZ  . TYR B 1 120 ? -1.899  -8.225  26.335 1.00 18.25  ? 143 TYR B CZ  1 ? 
ATOM   3370 O OH  . TYR B 1 120 ? -2.806  -7.476  25.658 1.00 22.27  ? 143 TYR B OH  1 ? 
ATOM   3371 N N   . TRP B 1 121 ? 1.311   -13.440 30.212 1.00 15.52  ? 144 TRP B N   1 ? 
ATOM   3372 C CA  . TRP B 1 121 ? 2.266   -14.536 30.472 1.00 19.66  ? 144 TRP B CA  1 ? 
ATOM   3373 C C   . TRP B 1 121 ? 2.324   -15.384 29.210 1.00 18.98  ? 144 TRP B C   1 ? 
ATOM   3374 O O   . TRP B 1 121 ? 1.271   -15.707 28.672 1.00 16.53  ? 144 TRP B O   1 ? 
ATOM   3375 C CB  . TRP B 1 121 ? 1.799   -15.440 31.618 1.00 17.38  ? 144 TRP B CB  1 ? 
ATOM   3376 C CG  . TRP B 1 121 ? 2.022   -14.918 33.009 1.00 17.43  ? 144 TRP B CG  1 ? 
ATOM   3377 C CD1 . TRP B 1 121 ? 2.505   -13.704 33.391 1.00 14.78  ? 144 TRP B CD1 1 ? 
ATOM   3378 C CD2 . TRP B 1 121 ? 1.733   -15.639 34.224 1.00 16.99  ? 144 TRP B CD2 1 ? 
ATOM   3379 N NE1 . TRP B 1 121 ? 2.545   -13.620 34.756 1.00 16.72  ? 144 TRP B NE1 1 ? 
ATOM   3380 C CE2 . TRP B 1 121 ? 2.078   -14.789 35.295 1.00 15.54  ? 144 TRP B CE2 1 ? 
ATOM   3381 C CE3 . TRP B 1 121 ? 1.219   -16.908 34.504 1.00 14.78  ? 144 TRP B CE3 1 ? 
ATOM   3382 C CZ2 . TRP B 1 121 ? 1.924   -15.176 36.623 1.00 15.71  ? 144 TRP B CZ2 1 ? 
ATOM   3383 C CZ3 . TRP B 1 121 ? 1.064   -17.284 35.817 1.00 17.13  ? 144 TRP B CZ3 1 ? 
ATOM   3384 C CH2 . TRP B 1 121 ? 1.411   -16.429 36.859 1.00 15.58  ? 144 TRP B CH2 1 ? 
ATOM   3385 N N   . HIS B 1 122 ? 3.525   -15.764 28.806 1.00 18.52  ? 145 HIS B N   1 ? 
ATOM   3386 C CA  . HIS B 1 122 ? 3.685   -16.573 27.579 1.00 17.85  ? 145 HIS B CA  1 ? 
ATOM   3387 C C   . HIS B 1 122 ? 3.577   -18.070 27.856 1.00 19.47  ? 145 HIS B C   1 ? 
ATOM   3388 O O   . HIS B 1 122 ? 3.834   -18.505 28.968 1.00 20.20  ? 145 HIS B O   1 ? 
ATOM   3389 C CB  . HIS B 1 122 ? 5.073   -16.366 26.972 1.00 19.87  ? 145 HIS B CB  1 ? 
ATOM   3390 C CG  . HIS B 1 122 ? 5.416   -14.992 26.525 1.00 18.54  ? 145 HIS B CG  1 ? 
ATOM   3391 N ND1 . HIS B 1 122 ? 4.565   -14.174 25.823 1.00 17.79  ? 145 HIS B ND1 1 ? 
ATOM   3392 C CD2 . HIS B 1 122 ? 6.554   -14.312 26.657 1.00 19.40  ? 145 HIS B CD2 1 ? 
ATOM   3393 C CE1 . HIS B 1 122 ? 5.177   -13.033 25.567 1.00 23.39  ? 145 HIS B CE1 1 ? 
ATOM   3394 N NE2 . HIS B 1 122 ? 6.384   -13.094 26.071 1.00 21.36  ? 145 HIS B NE2 1 ? 
ATOM   3395 N N   . ASN B 1 123 ? 3.123   -18.828 26.862 1.00 18.51  ? 146 ASN B N   1 ? 
ATOM   3396 C CA  . ASN B 1 123 ? 3.248   -20.303 26.954 1.00 18.28  ? 146 ASN B CA  1 ? 
ATOM   3397 C C   . ASN B 1 123 ? 4.145   -20.651 25.759 1.00 19.72  ? 146 ASN B C   1 ? 
ATOM   3398 O O   . ASN B 1 123 ? 5.328   -20.884 25.945 1.00 21.00  ? 146 ASN B O   1 ? 
ATOM   3399 C CB  . ASN B 1 123 ? 1.921   -21.053 27.028 1.00 19.24  ? 146 ASN B CB  1 ? 
ATOM   3400 C CG  . ASN B 1 123 ? 2.080   -22.552 27.146 1.00 20.97  ? 146 ASN B CG  1 ? 
ATOM   3401 O OD1 . ASN B 1 123 ? 3.154   -23.098 26.883 1.00 22.80  ? 146 ASN B OD1 1 ? 
ATOM   3402 N ND2 . ASN B 1 123 ? 1.020   -23.241 27.535 1.00 19.72  ? 146 ASN B ND2 1 ? 
ATOM   3403 N N   . GLY B 1 124 ? 3.569   -20.602 24.566 1.00 21.79  ? 147 GLY B N   1 ? 
ATOM   3404 C CA  . GLY B 1 124 ? 4.351   -20.869 23.357 1.00 19.43  ? 147 GLY B CA  1 ? 
ATOM   3405 C C   . GLY B 1 124 ? 3.531   -20.837 22.096 1.00 23.45  ? 147 GLY B C   1 ? 
ATOM   3406 O O   . GLY B 1 124 ? 2.344   -20.494 22.160 1.00 23.86  ? 147 GLY B O   1 ? 
ATOM   3407 N N   . MET B 1 125 ? 4.173   -21.155 20.986 1.00 22.47  ? 148 MET B N   1 ? 
ATOM   3408 C CA  . MET B 1 125 ? 3.454   -21.256 19.698 1.00 22.93  ? 148 MET B CA  1 ? 
ATOM   3409 C C   . MET B 1 125 ? 2.623   -22.546 19.677 1.00 22.33  ? 148 MET B C   1 ? 
ATOM   3410 O O   . MET B 1 125 ? 2.922   -23.481 20.426 1.00 18.91  ? 148 MET B O   1 ? 
ATOM   3411 C CB  . MET B 1 125 ? 4.444   -21.236 18.525 1.00 21.38  ? 148 MET B CB  1 ? 
ATOM   3412 C CG  . MET B 1 125 ? 5.380   -20.052 18.535 1.00 21.38  ? 148 MET B CG  1 ? 
ATOM   3413 S SD  . MET B 1 125 ? 4.535   -18.476 18.308 1.00 26.63  ? 148 MET B SD  1 ? 
ATOM   3414 C CE  . MET B 1 125 ? 4.104   -18.550 16.566 1.00 23.58  ? 148 MET B CE  1 ? 
ATOM   3415 N N   . LYS B 1 126 ? 1.639   -22.569 18.795 1.00 20.45  ? 149 LYS B N   1 ? 
ATOM   3416 C CA  . LYS B 1 126 ? 0.796   -23.767 18.664 1.00 21.13  ? 149 LYS B CA  1 ? 
ATOM   3417 C C   . LYS B 1 126 ? 1.297   -24.668 17.530 1.00 22.03  ? 149 LYS B C   1 ? 
ATOM   3418 O O   . LYS B 1 126 ? 1.785   -24.143 16.513 1.00 20.28  ? 149 LYS B O   1 ? 
ATOM   3419 C CB  . LYS B 1 126 ? -0.686  -23.438 18.437 1.00 18.59  ? 149 LYS B CB  1 ? 
ATOM   3420 C CG  . LYS B 1 126 ? -1.470  -22.984 19.649 1.00 18.87  ? 149 LYS B CG  1 ? 
ATOM   3421 C CD  . LYS B 1 126 ? -2.935  -22.730 19.324 1.00 16.38  ? 149 LYS B CD  1 ? 
ATOM   3422 C CE  . LYS B 1 126 ? -3.130  -21.802 18.174 1.00 18.21  ? 149 LYS B CE  1 ? 
ATOM   3423 N NZ  . LYS B 1 126 ? -4.500  -21.289 18.122 1.00 18.81  ? 149 LYS B NZ  1 ? 
ATOM   3424 N N   . GLN B 1 127 ? 1.119   -25.962 17.726 1.00 17.20  ? 150 GLN B N   1 ? 
ATOM   3425 C CA  . GLN B 1 127 ? 1.463   -26.965 16.709 1.00 22.17  ? 150 GLN B CA  1 ? 
ATOM   3426 C C   . GLN B 1 127 ? 0.176   -27.715 16.357 1.00 24.76  ? 150 GLN B C   1 ? 
ATOM   3427 O O   . GLN B 1 127 ? -0.835  -27.481 17.016 1.00 20.60  ? 150 GLN B O   1 ? 
ATOM   3428 C CB  . GLN B 1 127 ? 2.470   -27.949 17.299 1.00 20.56  ? 150 GLN B CB  1 ? 
ATOM   3429 C CG  . GLN B 1 127 ? 3.588   -27.284 18.094 1.00 22.57  ? 150 GLN B CG  1 ? 
ATOM   3430 C CD  . GLN B 1 127 ? 4.305   -26.193 17.330 1.00 25.61  ? 150 GLN B CD  1 ? 
ATOM   3431 O OE1 . GLN B 1 127 ? 4.357   -26.194 16.097 1.00 31.22  ? 150 GLN B OE1 1 ? 
ATOM   3432 N NE2 . GLN B 1 127 ? 4.864   -25.243 18.061 1.00 24.29  ? 150 GLN B NE2 1 ? 
ATOM   3433 N N   . LEU B 1 128 ? 0.258   -28.598 15.368 1.00 22.49  ? 151 LEU B N   1 ? 
ATOM   3434 C CA  . LEU B 1 128 ? -0.917  -29.393 14.955 1.00 25.13  ? 151 LEU B CA  1 ? 
ATOM   3435 C C   . LEU B 1 128 ? -0.701  -30.852 15.358 1.00 24.06  ? 151 LEU B C   1 ? 
ATOM   3436 O O   . LEU B 1 128 ? 0.452   -31.274 15.445 1.00 26.43  ? 151 LEU B O   1 ? 
ATOM   3437 C CB  . LEU B 1 128 ? -1.164  -29.253 13.458 1.00 26.96  ? 151 LEU B CB  1 ? 
ATOM   3438 C CG  . LEU B 1 128 ? -1.657  -27.887 12.986 1.00 24.30  ? 151 LEU B CG  1 ? 
ATOM   3439 C CD1 . LEU B 1 128 ? -1.534  -27.828 11.480 1.00 28.95  ? 151 LEU B CD1 1 ? 
ATOM   3440 C CD2 . LEU B 1 128 ? -3.091  -27.685 13.427 1.00 22.13  ? 151 LEU B CD2 1 ? 
ATOM   3441 N N   . SER B 1 129 ? -1.791  -31.552 15.640 1.00 24.77  ? 152 SER B N   1 ? 
ATOM   3442 C CA  . SER B 1 129 ? -1.708  -32.984 15.997 1.00 19.91  ? 152 SER B CA  1 ? 
ATOM   3443 C C   . SER B 1 129 ? -2.913  -33.731 15.418 1.00 20.29  ? 152 SER B C   1 ? 
ATOM   3444 O O   . SER B 1 129 ? -3.955  -33.115 15.287 1.00 20.29  ? 152 SER B O   1 ? 
ATOM   3445 C CB  . SER B 1 129 ? -1.620  -33.187 17.495 1.00 19.87  ? 152 SER B CB  1 ? 
ATOM   3446 O OG  . SER B 1 129 ? -2.844  -32.890 18.144 1.00 23.89  ? 152 SER B OG  1 ? 
ATOM   3447 N N   . ALA B 1 130 ? -2.731  -35.012 15.115 1.00 23.42  ? 153 ALA B N   1 ? 
ATOM   3448 C CA  . ALA B 1 130 ? -3.837  -35.866 14.648 1.00 22.43  ? 153 ALA B CA  1 ? 
ATOM   3449 C C   . ALA B 1 130 ? -3.399  -37.329 14.687 1.00 21.44  ? 153 ALA B C   1 ? 
ATOM   3450 O O   . ALA B 1 130 ? -2.245  -37.616 14.991 1.00 23.32  ? 153 ALA B O   1 ? 
ATOM   3451 C CB  . ALA B 1 130 ? -4.267  -35.490 13.258 1.00 24.39  ? 153 ALA B CB  1 ? 
ATOM   3452 N N   . ASN B 1 131 ? -4.335  -38.211 14.375 1.00 26.95  ? 154 ASN B N   1 ? 
ATOM   3453 C CA  . ASN B 1 131 ? -3.995  -39.657 14.292 1.00 30.95  ? 154 ASN B CA  1 ? 
ATOM   3454 C C   . ASN B 1 131 ? -3.608  -39.966 12.842 1.00 31.52  ? 154 ASN B C   1 ? 
ATOM   3455 O O   . ASN B 1 131 ? -3.493  -41.152 12.505 1.00 28.79  ? 154 ASN B O   1 ? 
ATOM   3456 C CB  . ASN B 1 131 ? -5.073  -40.512 14.929 1.00 29.25  ? 154 ASN B CB  1 ? 
ATOM   3457 C CG  . ASN B 1 131 ? -4.850  -40.599 16.419 1.00 35.78  ? 154 ASN B CG  1 ? 
ATOM   3458 O OD1 . ASN B 1 131 ? -3.737  -40.899 16.861 1.00 40.06  ? 154 ASN B OD1 1 ? 
ATOM   3459 N ND2 . ASN B 1 131 ? -5.879  -40.322 17.201 1.00 26.90  ? 154 ASN B ND2 1 ? 
ATOM   3460 N N   . ARG B 1 132 ? -3.382  -38.921 12.050 1.00 24.21  ? 155 ARG B N   1 ? 
ATOM   3461 C CA  . ARG B 1 132 ? -2.882  -39.104 10.672 1.00 26.70  ? 155 ARG B CA  1 ? 
ATOM   3462 C C   . ARG B 1 132 ? -1.925  -37.944 10.336 1.00 31.43  ? 155 ARG B C   1 ? 
ATOM   3463 O O   . ARG B 1 132 ? -2.026  -36.878 10.947 1.00 28.09  ? 155 ARG B O   1 ? 
ATOM   3464 C CB  . ARG B 1 132 ? -4.055  -39.234 9.705  1.00 35.25  ? 155 ARG B CB  1 ? 
ATOM   3465 C CG  . ARG B 1 132 ? -5.016  -38.057 9.670  1.00 44.25  ? 155 ARG B CG  1 ? 
ATOM   3466 C CD  . ARG B 1 132 ? -5.795  -38.098 8.370  1.00 54.42  ? 155 ARG B CD  1 ? 
ATOM   3467 N NE  . ARG B 1 132 ? -4.906  -38.283 7.219  1.00 60.16  ? 155 ARG B NE  1 ? 
ATOM   3468 C CZ  . ARG B 1 132 ? -4.047  -37.366 6.811  1.00 58.02  ? 155 ARG B CZ  1 ? 
ATOM   3469 N NH1 . ARG B 1 132 ? -4.154  -36.139 7.274  1.00 79.25  ? 155 ARG B NH1 1 ? 
ATOM   3470 N NH2 . ARG B 1 132 ? -3.082  -37.668 5.961  1.00 44.00  ? 155 ARG B NH2 1 ? 
ATOM   3471 N N   . PRO B 1 133 ? -0.962  -38.138 9.418  1.00 34.39  ? 156 PRO B N   1 ? 
ATOM   3472 C CA  . PRO B 1 133 ? -0.022  -37.081 9.096  1.00 31.09  ? 156 PRO B CA  1 ? 
ATOM   3473 C C   . PRO B 1 133 ? -0.664  -35.799 8.640  1.00 31.89  ? 156 PRO B C   1 ? 
ATOM   3474 O O   . PRO B 1 133 ? -1.666  -35.856 7.927  1.00 46.47  ? 156 PRO B O   1 ? 
ATOM   3475 C CB  . PRO B 1 133 ? 0.795   -37.713 7.975  1.00 35.40  ? 156 PRO B CB  1 ? 
ATOM   3476 C CG  . PRO B 1 133 ? 0.720   -39.190 8.267  1.00 38.48  ? 156 PRO B CG  1 ? 
ATOM   3477 C CD  . PRO B 1 133 ? -0.711  -39.379 8.715  1.00 30.63  ? 156 PRO B CD  1 ? 
ATOM   3478 N N   . LEU B 1 134 ? -0.083  -34.662 9.003  1.00 28.73  ? 157 LEU B N   1 ? 
ATOM   3479 C CA  . LEU B 1 134 ? -0.581  -33.353 8.520  1.00 29.25  ? 157 LEU B CA  1 ? 
ATOM   3480 C C   . LEU B 1 134 ? 0.615   -32.630 7.886  1.00 31.67  ? 157 LEU B C   1 ? 
ATOM   3481 O O   . LEU B 1 134 ? 1.246   -31.830 8.563  1.00 32.99  ? 157 LEU B O   1 ? 
ATOM   3482 C CB  . LEU B 1 134 ? -1.225  -32.543 9.648  1.00 35.85  ? 157 LEU B CB  1 ? 
ATOM   3483 C CG  . LEU B 1 134 ? -2.412  -33.195 10.363 1.00 32.03  ? 157 LEU B CG  1 ? 
ATOM   3484 C CD1 . LEU B 1 134 ? -2.798  -32.396 11.589 1.00 30.95  ? 157 LEU B CD1 1 ? 
ATOM   3485 C CD2 . LEU B 1 134 ? -3.585  -33.319 9.417  1.00 34.24  ? 157 LEU B CD2 1 ? 
ATOM   3486 N N   . LEU B 1 135 ? 0.916   -32.952 6.633  1.00 38.57  ? 158 LEU B N   1 ? 
ATOM   3487 C CA  . LEU B 1 135 ? 2.097   -32.378 5.943  1.00 40.74  ? 158 LEU B CA  1 ? 
ATOM   3488 C C   . LEU B 1 135 ? 1.631   -31.202 5.103  1.00 36.79  ? 158 LEU B C   1 ? 
ATOM   3489 O O   . LEU B 1 135 ? 2.300   -30.160 5.110  1.00 35.05  ? 158 LEU B O   1 ? 
ATOM   3490 C CB  . LEU B 1 135 ? 2.700   -33.464 5.056  1.00 39.08  ? 158 LEU B CB  1 ? 
ATOM   3491 C CG  . LEU B 1 135 ? 2.988   -34.819 5.705  1.00 36.19  ? 158 LEU B CG  1 ? 
ATOM   3492 C CD1 . LEU B 1 135 ? 3.769   -35.666 4.718  1.00 32.55  ? 158 LEU B CD1 1 ? 
ATOM   3493 C CD2 . LEU B 1 135 ? 3.766   -34.666 6.988  1.00 30.26  ? 158 LEU B CD2 1 ? 
ATOM   3494 N N   . GLU B 1 136 ? 0.501   -31.392 4.432  1.00 35.93  ? 159 GLU B N   1 ? 
ATOM   3495 C CA  . GLU B 1 136 ? -0.058  -30.324 3.577  1.00 34.76  ? 159 GLU B CA  1 ? 
ATOM   3496 C C   . GLU B 1 136 ? -1.450  -29.905 4.080  1.00 31.06  ? 159 GLU B C   1 ? 
ATOM   3497 O O   . GLU B 1 136 ? -2.126  -30.711 4.718  1.00 29.68  ? 159 GLU B O   1 ? 
ATOM   3498 C CB  . GLU B 1 136 ? -0.075  -30.825 2.130  1.00 43.50  ? 159 GLU B CB  1 ? 
ATOM   3499 C CG  . GLU B 1 136 ? 1.218   -31.504 1.692  1.00 40.58  ? 159 GLU B CG  1 ? 
ATOM   3500 C CD  . GLU B 1 136 ? 2.370   -30.552 1.442  1.00 38.37  ? 159 GLU B CD  1 ? 
ATOM   3501 O OE1 . GLU B 1 136 ? 3.512   -31.042 1.386  1.00 46.09  ? 159 GLU B OE1 1 ? 
ATOM   3502 O OE2 . GLU B 1 136 ? 2.135   -29.338 1.307  1.00 39.40  ? 159 GLU B OE2 1 ? 
ATOM   3503 N N   . PRO B 1 137 ? -1.910  -28.680 3.764  1.00 29.17  ? 160 PRO B N   1 ? 
ATOM   3504 C CA  . PRO B 1 137 ? -3.189  -28.196 4.264  1.00 34.75  ? 160 PRO B CA  1 ? 
ATOM   3505 C C   . PRO B 1 137 ? -4.427  -29.045 3.934  1.00 38.29  ? 160 PRO B C   1 ? 
ATOM   3506 O O   . PRO B 1 137 ? -5.380  -29.059 4.705  1.00 38.42  ? 160 PRO B O   1 ? 
ATOM   3507 C CB  . PRO B 1 137 ? -3.250  -26.776 3.663  1.00 32.27  ? 160 PRO B CB  1 ? 
ATOM   3508 C CG  . PRO B 1 137 ? -1.830  -26.418 3.342  1.00 30.72  ? 160 PRO B CG  1 ? 
ATOM   3509 C CD  . PRO B 1 137 ? -1.195  -27.723 2.948  1.00 32.60  ? 160 PRO B CD  1 ? 
ATOM   3510 N N   . GLU B 1 138 ? -4.388  -29.786 2.826  1.00 34.97  ? 161 GLU B N   1 ? 
ATOM   3511 C CA  . GLU B 1 138 ? -5.532  -30.624 2.416  1.00 30.73  ? 161 GLU B CA  1 ? 
ATOM   3512 C C   . GLU B 1 138 ? -5.650  -31.845 3.331  1.00 33.74  ? 161 GLU B C   1 ? 
ATOM   3513 O O   . GLU B 1 138 ? -6.748  -32.397 3.418  1.00 28.79  ? 161 GLU B O   1 ? 
ATOM   3514 C CB  . GLU B 1 138 ? -5.291  -31.033 0.969  1.00 42.30  ? 161 GLU B CB  1 ? 
ATOM   3515 C CG  . GLU B 1 138 ? -3.910  -31.639 0.747  1.00 54.62  ? 161 GLU B CG  1 ? 
ATOM   3516 C CD  . GLU B 1 138 ? -2.990  -30.750 -0.066 1.00 74.06  ? 161 GLU B CD  1 ? 
ATOM   3517 O OE1 . GLU B 1 138 ? -2.847  -29.554 0.269  1.00 70.12  ? 161 GLU B OE1 1 ? 
ATOM   3518 O OE2 . GLU B 1 138 ? -2.414  -31.270 -1.043 1.00 72.27  ? 161 GLU B OE2 1 ? 
ATOM   3519 N N   . ASP B 1 139 ? -4.560  -32.215 4.005  1.00 33.85  ? 162 ASP B N   1 ? 
ATOM   3520 C CA  . ASP B 1 139 ? -4.545  -33.386 4.916  1.00 32.11  ? 162 ASP B CA  1 ? 
ATOM   3521 C C   . ASP B 1 139 ? -5.477  -33.156 6.112  1.00 31.82  ? 162 ASP B C   1 ? 
ATOM   3522 O O   . ASP B 1 139 ? -5.779  -34.134 6.806  1.00 39.62  ? 162 ASP B O   1 ? 
ATOM   3523 C CB  . ASP B 1 139 ? -3.129  -33.700 5.369  1.00 34.80  ? 162 ASP B CB  1 ? 
ATOM   3524 C CG  . ASP B 1 139 ? -2.121  -34.067 4.292  1.00 39.86  ? 162 ASP B CG  1 ? 
ATOM   3525 O OD1 . ASP B 1 139 ? -2.552  -34.398 3.172  1.00 41.11  ? 162 ASP B OD1 1 ? 
ATOM   3526 O OD2 . ASP B 1 139 ? -0.914  -34.029 4.596  1.00 34.73  ? 162 ASP B OD2 1 ? 
ATOM   3527 N N   . ALA B 1 140 ? -5.906  -31.915 6.349  1.00 31.19  ? 163 ALA B N   1 ? 
ATOM   3528 C CA  . ALA B 1 140 ? -6.808  -31.580 7.471  1.00 29.36  ? 163 ALA B CA  1 ? 
ATOM   3529 C C   . ALA B 1 140 ? -8.279  -31.817 7.113  1.00 35.69  ? 163 ALA B C   1 ? 
ATOM   3530 O O   . ALA B 1 140 ? -9.112  -31.874 8.025  1.00 26.81  ? 163 ALA B O   1 ? 
ATOM   3531 C CB  . ALA B 1 140 ? -6.602  -30.144 7.834  1.00 31.67  ? 163 ALA B CB  1 ? 
ATOM   3532 N N   . ARG B 1 141 ? -8.575  -31.976 5.824  1.00 31.83  ? 164 ARG B N   1 ? 
ATOM   3533 C CA  . ARG B 1 141 ? -9.989  -32.085 5.379  1.00 35.05  ? 164 ARG B CA  1 ? 
ATOM   3534 C C   . ARG B 1 141 ? -10.723 -33.254 6.051  1.00 25.87  ? 164 ARG B C   1 ? 
ATOM   3535 O O   . ARG B 1 141 ? -10.167 -34.346 6.118  1.00 31.83  ? 164 ARG B O   1 ? 
ATOM   3536 C CB  . ARG B 1 141 ? -10.094 -32.183 3.850  1.00 33.43  ? 164 ARG B CB  1 ? 
ATOM   3537 C CG  . ARG B 1 141 ? -9.703  -30.933 3.081  1.00 35.65  ? 164 ARG B CG  1 ? 
ATOM   3538 C CD  . ARG B 1 141 ? -9.531  -31.266 1.609  1.00 39.35  ? 164 ARG B CD  1 ? 
ATOM   3539 N NE  . ARG B 1 141 ? -10.723 -31.920 1.058  1.00 47.81  ? 164 ARG B NE  1 ? 
ATOM   3540 C CZ  . ARG B 1 141 ? -11.759 -31.269 0.552  1.00 34.87  ? 164 ARG B CZ  1 ? 
ATOM   3541 N NH1 . ARG B 1 141 ? -12.915 -31.886 0.399  1.00 37.40  ? 164 ARG B NH1 1 ? 
ATOM   3542 N NH2 . ARG B 1 141 ? -11.631 -30.005 0.198  1.00 37.08  ? 164 ARG B NH2 1 ? 
ATOM   3543 N N   . GLY B 1 142 ? -11.910 -32.982 6.573  1.00 30.11  ? 165 GLY B N   1 ? 
ATOM   3544 C CA  . GLY B 1 142 ? -12.742 -34.038 7.170  1.00 36.05  ? 165 GLY B CA  1 ? 
ATOM   3545 C C   . GLY B 1 142 ? -12.435 -34.345 8.616  1.00 35.59  ? 165 GLY B C   1 ? 
ATOM   3546 O O   . GLY B 1 142 ? -13.265 -35.002 9.251  1.00 40.15  ? 165 GLY B O   1 ? 
ATOM   3547 N N   . LEU B 1 143 ? -11.293 -33.905 9.113  1.00 30.44  ? 166 LEU B N   1 ? 
ATOM   3548 C CA  . LEU B 1 143 ? -10.918 -34.288 10.498 1.00 29.11  ? 166 LEU B CA  1 ? 
ATOM   3549 C C   . LEU B 1 143 ? -11.718 -33.485 11.539 1.00 28.71  ? 166 LEU B C   1 ? 
ATOM   3550 O O   . LEU B 1 143 ? -12.258 -32.429 11.206 1.00 29.58  ? 166 LEU B O   1 ? 
ATOM   3551 C CB  . LEU B 1 143 ? -9.415  -34.140 10.712 1.00 27.52  ? 166 LEU B CB  1 ? 
ATOM   3552 C CG  . LEU B 1 143 ? -8.509  -35.020 9.851  1.00 35.44  ? 166 LEU B CG  1 ? 
ATOM   3553 C CD1 . LEU B 1 143 ? -7.072  -34.673 10.177 1.00 36.11  ? 166 LEU B CD1 1 ? 
ATOM   3554 C CD2 . LEU B 1 143 ? -8.784  -36.478 10.144 1.00 28.82  ? 166 LEU B CD2 1 ? 
ATOM   3555 N N   . LYS B 1 144 ? -11.746 -34.002 12.762 1.00 26.30  ? 167 LYS B N   1 ? 
ATOM   3556 C CA  . LYS B 1 144 ? -12.427 -33.310 13.869 1.00 26.19  ? 167 LYS B CA  1 ? 
ATOM   3557 C C   . LYS B 1 144 ? -11.338 -32.743 14.783 1.00 23.72  ? 167 LYS B C   1 ? 
ATOM   3558 O O   . LYS B 1 144 ? -10.613 -33.530 15.381 1.00 21.16  ? 167 LYS B O   1 ? 
ATOM   3559 C CB  . LYS B 1 144 ? -13.341 -34.297 14.590 1.00 22.49  ? 167 LYS B CB  1 ? 
ATOM   3560 C CG  . LYS B 1 144 ? -14.393 -34.942 13.712 1.00 26.96  ? 167 LYS B CG  1 ? 
ATOM   3561 C CD  . LYS B 1 144 ? -15.320 -35.816 14.542 1.00 30.79  ? 167 LYS B CD  1 ? 
ATOM   3562 C CE  . LYS B 1 144 ? -16.666 -35.937 13.922 1.00 44.59  ? 167 LYS B CE  1 ? 
ATOM   3563 N NZ  . LYS B 1 144 ? -16.806 -37.216 13.224 1.00 51.26  ? 167 LYS B NZ  1 ? 
ATOM   3564 N N   . PHE B 1 145 ? -11.257 -31.422 14.840 1.00 23.50  ? 168 PHE B N   1 ? 
ATOM   3565 C CA  . PHE B 1 145 ? -10.224 -30.744 15.654 1.00 25.66  ? 168 PHE B CA  1 ? 
ATOM   3566 C C   . PHE B 1 145 ? -10.834 -30.129 16.907 1.00 23.15  ? 168 PHE B C   1 ? 
ATOM   3567 O O   . PHE B 1 145 ? -11.819 -29.403 16.823 1.00 20.57  ? 168 PHE B O   1 ? 
ATOM   3568 C CB  . PHE B 1 145 ? -9.568  -29.633 14.836 1.00 21.75  ? 168 PHE B CB  1 ? 
ATOM   3569 C CG  . PHE B 1 145 ? -8.521  -30.117 13.848 1.00 23.08  ? 168 PHE B CG  1 ? 
ATOM   3570 C CD1 . PHE B 1 145 ? -7.200  -30.285 14.237 1.00 20.07  ? 168 PHE B CD1 1 ? 
ATOM   3571 C CD2 . PHE B 1 145 ? -8.863  -30.399 12.533 1.00 24.27  ? 168 PHE B CD2 1 ? 
ATOM   3572 C CE1 . PHE B 1 145 ? -6.249  -30.727 13.336 1.00 28.54  ? 168 PHE B CE1 1 ? 
ATOM   3573 C CE2 . PHE B 1 145 ? -7.905  -30.834 11.635 1.00 29.60  ? 168 PHE B CE2 1 ? 
ATOM   3574 C CZ  . PHE B 1 145 ? -6.603  -30.998 12.038 1.00 27.16  ? 168 PHE B CZ  1 ? 
ATOM   3575 N N   . ARG B 1 146 ? -10.241 -30.444 18.049 1.00 22.15  ? 169 ARG B N   1 ? 
ATOM   3576 C CA  . ARG B 1 146 ? -10.681 -29.773 19.283 1.00 20.09  ? 169 ARG B CA  1 ? 
ATOM   3577 C C   . ARG B 1 146 ? -10.085 -28.371 19.246 1.00 20.92  ? 169 ARG B C   1 ? 
ATOM   3578 O O   . ARG B 1 146 ? -8.898  -28.238 18.942 1.00 17.68  ? 169 ARG B O   1 ? 
ATOM   3579 C CB  . ARG B 1 146 ? -10.153 -30.416 20.564 1.00 19.66  ? 169 ARG B CB  1 ? 
ATOM   3580 C CG  . ARG B 1 146 ? -10.496 -29.687 21.851 1.00 18.21  ? 169 ARG B CG  1 ? 
ATOM   3581 C CD  . ARG B 1 146 ? -9.323  -28.886 22.368 1.00 16.48  ? 169 ARG B CD  1 ? 
ATOM   3582 N NE  . ARG B 1 146 ? -9.731  -27.962 23.428 1.00 16.37  ? 169 ARG B NE  1 ? 
ATOM   3583 C CZ  . ARG B 1 146 ? -8.902  -27.133 24.035 1.00 19.00  ? 169 ARG B CZ  1 ? 
ATOM   3584 N NH1 . ARG B 1 146 ? -7.628  -27.119 23.696 1.00 17.44  ? 169 ARG B NH1 1 ? 
ATOM   3585 N NH2 . ARG B 1 146 ? -9.351  -26.328 24.977 1.00 15.03  ? 169 ARG B NH2 1 ? 
ATOM   3586 N N   . VAL B 1 147 ? -10.903 -27.383 19.562 1.00 19.80  ? 170 VAL B N   1 ? 
ATOM   3587 C CA  . VAL B 1 147 ? -10.370 -26.014 19.679 1.00 15.79  ? 170 VAL B CA  1 ? 
ATOM   3588 C C   . VAL B 1 147 ? -10.799 -25.449 21.039 1.00 18.94  ? 170 VAL B C   1 ? 
ATOM   3589 O O   . VAL B 1 147 ? -11.742 -25.964 21.655 1.00 18.40  ? 170 VAL B O   1 ? 
ATOM   3590 C CB  . VAL B 1 147 ? -10.886 -25.109 18.539 1.00 19.29  ? 170 VAL B CB  1 ? 
ATOM   3591 C CG1 . VAL B 1 147 ? -10.203 -25.416 17.217 1.00 18.86  ? 170 VAL B CG1 1 ? 
ATOM   3592 C CG2 . VAL B 1 147 ? -12.399 -25.165 18.392 1.00 16.91  ? 170 VAL B CG2 1 ? 
ATOM   3593 N N   . GLN B 1 148 ? -10.070 -24.450 21.493 1.00 16.01  ? 171 GLN B N   1 ? 
ATOM   3594 C CA  . GLN B 1 148 ? -10.561 -23.714 22.665 1.00 17.77  ? 171 GLN B CA  1 ? 
ATOM   3595 C C   . GLN B 1 148 ? -11.886 -23.065 22.220 1.00 18.09  ? 171 GLN B C   1 ? 
ATOM   3596 O O   . GLN B 1 148 ? -12.144 -22.985 21.017 1.00 20.15  ? 171 GLN B O   1 ? 
ATOM   3597 C CB  . GLN B 1 148 ? -9.517  -22.680 23.078 1.00 15.31  ? 171 GLN B CB  1 ? 
ATOM   3598 C CG  . GLN B 1 148 ? -8.107  -23.226 23.250 1.00 18.30  ? 171 GLN B CG  1 ? 
ATOM   3599 C CD  . GLN B 1 148 ? -7.057  -22.139 23.235 1.00 21.91  ? 171 GLN B CD  1 ? 
ATOM   3600 O OE1 . GLN B 1 148 ? -6.917  -21.368 24.188 1.00 20.43  ? 171 GLN B OE1 1 ? 
ATOM   3601 N NE2 . GLN B 1 148 ? -6.314  -22.059 22.144 1.00 18.02  ? 171 GLN B NE2 1 ? 
ATOM   3602 N N   . ALA B 1 149 ? -12.671 -22.575 23.167 1.00 18.53  ? 172 ALA B N   1 ? 
ATOM   3603 C CA  . ALA B 1 149 ? -13.952 -21.909 22.846 1.00 18.84  ? 172 ALA B CA  1 ? 
ATOM   3604 C C   . ALA B 1 149 ? -13.684 -20.537 22.207 1.00 22.54  ? 172 ALA B C   1 ? 
ATOM   3605 O O   . ALA B 1 149 ? -13.711 -19.530 22.930 1.00 19.52  ? 172 ALA B O   1 ? 
ATOM   3606 C CB  . ALA B 1 149 ? -14.794 -21.834 24.095 1.00 18.39  ? 172 ALA B CB  1 ? 
ATOM   3607 N N   . SER B 1 150 ? -13.416 -20.524 20.901 1.00 19.47  ? 173 SER B N   1 ? 
ATOM   3608 C CA  . SER B 1 150 ? -13.097 -19.284 20.141 1.00 16.93  ? 173 SER B CA  1 ? 
ATOM   3609 C C   . SER B 1 150 ? -13.724 -19.357 18.743 1.00 20.20  ? 173 SER B C   1 ? 
ATOM   3610 O O   . SER B 1 150 ? -13.496 -20.348 18.051 1.00 22.40  ? 173 SER B O   1 ? 
ATOM   3611 C CB  . SER B 1 150 ? -11.605 -19.044 20.009 1.00 16.97  ? 173 SER B CB  1 ? 
ATOM   3612 O OG  . SER B 1 150 ? -11.300 -18.105 18.992 1.00 18.16  ? 173 SER B OG  1 ? 
ATOM   3613 N N   . ASP B 1 151 ? -14.444 -18.313 18.344 1.00 23.69  ? 174 ASP B N   1 ? 
ATOM   3614 C CA  . ASP B 1 151 ? -15.011 -18.291 16.965 1.00 27.07  ? 174 ASP B CA  1 ? 
ATOM   3615 C C   . ASP B 1 151 ? -13.870 -18.272 15.937 1.00 24.92  ? 174 ASP B C   1 ? 
ATOM   3616 O O   . ASP B 1 151 ? -13.990 -18.926 14.905 1.00 26.46  ? 174 ASP B O   1 ? 
ATOM   3617 C CB  . ASP B 1 151 ? -15.967 -17.130 16.741 1.00 32.52  ? 174 ASP B CB  1 ? 
ATOM   3618 C CG  . ASP B 1 151 ? -17.084 -16.984 17.764 1.00 58.87  ? 174 ASP B CG  1 ? 
ATOM   3619 O OD1 . ASP B 1 151 ? -17.548 -18.019 18.278 1.00 66.38  ? 174 ASP B OD1 1 ? 
ATOM   3620 O OD2 . ASP B 1 151 ? -17.481 -15.834 18.033 1.00 79.59  ? 174 ASP B OD2 1 ? 
ATOM   3621 N N   . VAL B 1 152 ? -12.796 -17.551 16.240 1.00 25.45  ? 175 VAL B N   1 ? 
ATOM   3622 C CA  . VAL B 1 152 ? -11.650 -17.437 15.291 1.00 21.99  ? 175 VAL B CA  1 ? 
ATOM   3623 C C   . VAL B 1 152 ? -11.093 -18.847 15.047 1.00 26.10  ? 175 VAL B C   1 ? 
ATOM   3624 O O   . VAL B 1 152 ? -10.969 -19.255 13.892 1.00 23.77  ? 175 VAL B O   1 ? 
ATOM   3625 C CB  . VAL B 1 152 ? -10.545 -16.489 15.792 1.00 25.36  ? 175 VAL B CB  1 ? 
ATOM   3626 C CG1 . VAL B 1 152 ? -9.388  -16.400 14.807 1.00 23.05  ? 175 VAL B CG1 1 ? 
ATOM   3627 C CG2 . VAL B 1 152 ? -11.081 -15.105 16.122 1.00 25.13  ? 175 VAL B CG2 1 ? 
ATOM   3628 N N   . LEU B 1 153 ? -10.803 -19.549 16.129 1.00 18.35  ? 176 LEU B N   1 ? 
ATOM   3629 C CA  . LEU B 1 153 ? -10.215 -20.904 16.005 1.00 22.12  ? 176 LEU B CA  1 ? 
ATOM   3630 C C   . LEU B 1 153 ? -11.231 -21.875 15.378 1.00 21.19  ? 176 LEU B C   1 ? 
ATOM   3631 O O   . LEU B 1 153 ? -10.811 -22.744 14.616 1.00 23.15  ? 176 LEU B O   1 ? 
ATOM   3632 C CB  . LEU B 1 153 ? -9.732  -21.334 17.387 1.00 17.41  ? 176 LEU B CB  1 ? 
ATOM   3633 C CG  . LEU B 1 153 ? -8.731  -20.389 18.052 1.00 17.47  ? 176 LEU B CG  1 ? 
ATOM   3634 C CD1 . LEU B 1 153 ? -8.256  -20.964 19.371 1.00 15.75  ? 176 LEU B CD1 1 ? 
ATOM   3635 C CD2 . LEU B 1 153 ? -7.570  -20.140 17.113 1.00 14.97  ? 176 LEU B CD2 1 ? 
ATOM   3636 N N   . ASN B 1 154 ? -12.515 -21.694 15.675 1.00 24.41  ? 177 ASN B N   1 ? 
ATOM   3637 C CA  . ASN B 1 154 ? -13.557 -22.534 15.023 1.00 24.95  ? 177 ASN B CA  1 ? 
ATOM   3638 C C   . ASN B 1 154 ? -13.470 -22.293 13.511 1.00 24.15  ? 177 ASN B C   1 ? 
ATOM   3639 O O   . ASN B 1 154 ? -13.318 -23.267 12.774 1.00 25.11  ? 177 ASN B O   1 ? 
ATOM   3640 C CB  . ASN B 1 154 ? -14.936 -22.291 15.622 1.00 29.54  ? 177 ASN B CB  1 ? 
ATOM   3641 C CG  . ASN B 1 154 ? -16.063 -22.766 14.738 1.00 39.24  ? 177 ASN B CG  1 ? 
ATOM   3642 O OD1 . ASN B 1 154 ? -16.066 -23.916 14.294 1.00 50.97  ? 177 ASN B OD1 1 ? 
ATOM   3643 N ND2 . ASN B 1 154 ? -17.032 -21.904 14.478 1.00 45.67  ? 177 ASN B ND2 1 ? 
ATOM   3644 N N   . GLU B 1 155 ? -13.468 -21.033 13.099 1.00 20.56  ? 178 GLU B N   1 ? 
ATOM   3645 C CA  . GLU B 1 155 ? -13.400 -20.661 11.665 1.00 24.26  ? 178 GLU B CA  1 ? 
ATOM   3646 C C   . GLU B 1 155 ? -12.084 -21.117 11.018 1.00 30.95  ? 178 GLU B C   1 ? 
ATOM   3647 O O   . GLU B 1 155 ? -12.089 -21.405 9.818  1.00 28.94  ? 178 GLU B O   1 ? 
ATOM   3648 C CB  . GLU B 1 155 ? -13.555 -19.145 11.586 1.00 28.78  ? 178 GLU B CB  1 ? 
ATOM   3649 C CG  . GLU B 1 155 ? -14.086 -18.645 10.247 1.00 49.70  ? 178 GLU B CG  1 ? 
ATOM   3650 C CD  . GLU B 1 155 ? -15.405 -19.266 9.827  1.00 56.21  ? 178 GLU B CD  1 ? 
ATOM   3651 O OE1 . GLU B 1 155 ? -15.519 -19.640 8.643  1.00 72.91  ? 178 GLU B OE1 1 ? 
ATOM   3652 O OE2 . GLU B 1 155 ? -16.313 -19.375 10.673 1.00 56.91  ? 178 GLU B OE2 1 ? 
ATOM   3653 N N   . GLN B 1 156 ? -11.003 -21.161 11.788 1.00 24.90  ? 179 GLN B N   1 ? 
ATOM   3654 C CA  . GLN B 1 156 ? -9.685  -21.535 11.226 1.00 24.81  ? 179 GLN B CA  1 ? 
ATOM   3655 C C   . GLN B 1 156 ? -9.778  -22.957 10.647 1.00 24.21  ? 179 GLN B C   1 ? 
ATOM   3656 O O   . GLN B 1 156 ? -9.352  -23.155 9.518  1.00 28.53  ? 179 GLN B O   1 ? 
ATOM   3657 C CB  . GLN B 1 156 ? -8.595  -21.350 12.279 1.00 26.48  ? 179 GLN B CB  1 ? 
ATOM   3658 C CG  . GLN B 1 156 ? -7.368  -22.232 12.102 1.00 25.75  ? 179 GLN B CG  1 ? 
ATOM   3659 C CD  . GLN B 1 156 ? -6.414  -22.109 13.267 1.00 24.67  ? 179 GLN B CD  1 ? 
ATOM   3660 O OE1 . GLN B 1 156 ? -5.717  -21.103 13.425 1.00 29.92  ? 179 GLN B OE1 1 ? 
ATOM   3661 N NE2 . GLN B 1 156 ? -6.392  -23.128 14.107 1.00 26.71  ? 179 GLN B NE2 1 ? 
ATOM   3662 N N   . PHE B 1 157 ? -10.350 -23.885 11.398 1.00 23.09  ? 180 PHE B N   1 ? 
ATOM   3663 C CA  . PHE B 1 157 ? -10.396 -25.277 10.896 1.00 23.12  ? 180 PHE B CA  1 ? 
ATOM   3664 C C   . PHE B 1 157 ? -11.509 -25.398 9.846  1.00 33.12  ? 180 PHE B C   1 ? 
ATOM   3665 O O   . PHE B 1 157 ? -11.375 -26.209 8.924  1.00 35.64  ? 180 PHE B O   1 ? 
ATOM   3666 C CB  . PHE B 1 157 ? -10.498 -26.229 12.086 1.00 23.56  ? 180 PHE B CB  1 ? 
ATOM   3667 C CG  . PHE B 1 157 ? -9.166  -26.360 12.808 1.00 24.86  ? 180 PHE B CG  1 ? 
ATOM   3668 C CD1 . PHE B 1 157 ? -8.087  -26.987 12.201 1.00 27.22  ? 180 PHE B CD1 1 ? 
ATOM   3669 C CD2 . PHE B 1 157 ? -8.983  -25.825 14.073 1.00 22.49  ? 180 PHE B CD2 1 ? 
ATOM   3670 C CE1 . PHE B 1 157 ? -6.873  -27.098 12.853 1.00 22.82  ? 180 PHE B CE1 1 ? 
ATOM   3671 C CE2 . PHE B 1 157 ? -7.766  -25.943 14.723 1.00 25.72  ? 180 PHE B CE2 1 ? 
ATOM   3672 C CZ  . PHE B 1 157 ? -6.715  -26.579 14.113 1.00 21.29  ? 180 PHE B CZ  1 ? 
ATOM   3673 N N   . ARG B 1 158 ? -12.560 -24.600 9.982  1.00 30.09  ? 181 ARG B N   1 ? 
ATOM   3674 C CA  . ARG B 1 158 ? -13.657 -24.607 8.993  1.00 31.11  ? 181 ARG B CA  1 ? 
ATOM   3675 C C   . ARG B 1 158 ? -13.072 -24.164 7.645  1.00 28.89  ? 181 ARG B C   1 ? 
ATOM   3676 O O   . ARG B 1 158 ? -13.486 -24.712 6.621  1.00 28.59  ? 181 ARG B O   1 ? 
ATOM   3677 C CB  . ARG B 1 158 ? -14.789 -23.708 9.488  1.00 36.60  ? 181 ARG B CB  1 ? 
ATOM   3678 C CG  . ARG B 1 158 ? -15.573 -24.161 10.710 1.00 48.51  ? 181 ARG B CG  1 ? 
ATOM   3679 C CD  . ARG B 1 158 ? -15.798 -25.662 10.784 1.00 69.60  ? 181 ARG B CD  1 ? 
ATOM   3680 N NE  . ARG B 1 158 ? -16.527 -26.214 9.636  1.00 99.64  ? 181 ARG B NE  1 ? 
ATOM   3681 C CZ  . ARG B 1 158 ? -17.840 -26.147 9.435  1.00 80.18  ? 181 ARG B CZ  1 ? 
ATOM   3682 N NH1 . ARG B 1 158 ? -18.435 -24.977 9.303  1.00 74.74  ? 181 ARG B NH1 1 ? 
ATOM   3683 N NH2 . ARG B 1 158 ? -18.552 -27.255 9.351  1.00 62.61  ? 181 ARG B NH2 1 ? 
ATOM   3684 N N   . GLN B 1 159 ? -12.113 -23.244 7.677  1.00 24.96  ? 182 GLN B N   1 ? 
ATOM   3685 C CA  . GLN B 1 159 ? -11.464 -22.753 6.433  1.00 30.48  ? 182 GLN B CA  1 ? 
ATOM   3686 C C   . GLN B 1 159 ? -10.692 -23.903 5.765  1.00 36.30  ? 182 GLN B C   1 ? 
ATOM   3687 O O   . GLN B 1 159 ? -10.537 -23.873 4.536  1.00 36.59  ? 182 GLN B O   1 ? 
ATOM   3688 C CB  . GLN B 1 159 ? -10.540 -21.578 6.721  1.00 26.48  ? 182 GLN B CB  1 ? 
ATOM   3689 C CG  . GLN B 1 159 ? -9.856  -20.977 5.501  1.00 31.59  ? 182 GLN B CG  1 ? 
ATOM   3690 C CD  . GLN B 1 159 ? -10.809 -20.245 4.586  1.00 37.12  ? 182 GLN B CD  1 ? 
ATOM   3691 O OE1 . GLN B 1 159 ? -11.848 -19.733 5.011  1.00 47.92  ? 182 GLN B OE1 1 ? 
ATOM   3692 N NE2 . GLN B 1 159 ? -10.455 -20.184 3.313  1.00 51.13  ? 182 GLN B NE2 1 ? 
ATOM   3693 N N   . LEU B 1 160 ? -10.238 -24.876 6.548  1.00 32.33  ? 183 LEU B N   1 ? 
ATOM   3694 C CA  . LEU B 1 160 ? -9.465  -26.023 6.003  1.00 30.48  ? 183 LEU B CA  1 ? 
ATOM   3695 C C   . LEU B 1 160 ? -10.423 -27.169 5.653  1.00 34.57  ? 183 LEU B C   1 ? 
ATOM   3696 O O   . LEU B 1 160 ? -9.932  -28.277 5.400  1.00 31.79  ? 183 LEU B O   1 ? 
ATOM   3697 C CB  . LEU B 1 160 ? -8.397  -26.470 6.998  1.00 24.57  ? 183 LEU B CB  1 ? 
ATOM   3698 C CG  . LEU B 1 160 ? -7.256  -25.487 7.265  1.00 24.13  ? 183 LEU B CG  1 ? 
ATOM   3699 C CD1 . LEU B 1 160 ? -6.498  -25.909 8.507  1.00 26.37  ? 183 LEU B CD1 1 ? 
ATOM   3700 C CD2 . LEU B 1 160 ? -6.322  -25.393 6.076  1.00 20.99  ? 183 LEU B CD2 1 ? 
ATOM   3701 N N   . ARG B 1 161 ? -11.726 -26.899 5.665  1.00 34.29  ? 184 ARG B N   1 ? 
ATOM   3702 C CA  . ARG B 1 161 ? -12.767 -27.920 5.361  1.00 33.99  ? 184 ARG B CA  1 ? 
ATOM   3703 C C   . ARG B 1 161 ? -12.696 -29.017 6.428  1.00 30.19  ? 184 ARG B C   1 ? 
ATOM   3704 O O   . ARG B 1 161 ? -12.968 -30.182 6.114  1.00 33.34  ? 184 ARG B O   1 ? 
ATOM   3705 C CB  . ARG B 1 161 ? -12.705 -28.443 3.920  1.00 39.32  ? 184 ARG B CB  1 ? 
ATOM   3706 C CG  . ARG B 1 161 ? -12.640 -27.353 2.861  1.00 45.62  ? 184 ARG B CG  1 ? 
ATOM   3707 C CD  . ARG B 1 161 ? -13.902 -26.520 2.824  1.00 47.87  ? 184 ARG B CD  1 ? 
ATOM   3708 N NE  . ARG B 1 161 ? -14.774 -26.914 1.714  1.00 59.99  ? 184 ARG B NE  1 ? 
ATOM   3709 C CZ  . ARG B 1 161 ? -16.039 -27.283 1.845  1.00 54.19  ? 184 ARG B CZ  1 ? 
ATOM   3710 N NH1 . ARG B 1 161 ? -16.940 -26.408 2.240  1.00 43.98  ? 184 ARG B NH1 1 ? 
ATOM   3711 N NH2 . ARG B 1 161 ? -16.396 -28.526 1.582  1.00 47.70  ? 184 ARG B NH2 1 ? 
ATOM   3712 N N   . ALA B 1 162 ? -12.324 -28.630 7.638  1.00 26.72  ? 185 ALA B N   1 ? 
ATOM   3713 C CA  . ALA B 1 162 ? -12.321 -29.590 8.757  1.00 27.68  ? 185 ALA B CA  1 ? 
ATOM   3714 C C   . ALA B 1 162 ? -13.489 -29.270 9.687  1.00 28.53  ? 185 ALA B C   1 ? 
ATOM   3715 O O   . ALA B 1 162 ? -14.154 -28.243 9.479  1.00 27.30  ? 185 ALA B O   1 ? 
ATOM   3716 C CB  . ALA B 1 162 ? -11.007 -29.523 9.465  1.00 27.09  ? 185 ALA B CB  1 ? 
ATOM   3717 N N   . ILE B 1 163 ? -13.705 -30.120 10.685 1.00 25.05  ? 186 ILE B N   1 ? 
ATOM   3718 C CA  . ILE B 1 163 ? -14.803 -29.913 11.669 1.00 25.87  ? 186 ILE B CA  1 ? 
ATOM   3719 C C   . ILE B 1 163 ? -14.184 -29.451 12.994 1.00 33.40  ? 186 ILE B C   1 ? 
ATOM   3720 O O   . ILE B 1 163 ? -13.262 -30.116 13.459 1.00 29.98  ? 186 ILE B O   1 ? 
ATOM   3721 C CB  . ILE B 1 163 ? -15.623 -31.198 11.875 1.00 30.96  ? 186 ILE B CB  1 ? 
ATOM   3722 C CG1 . ILE B 1 163 ? -16.371 -31.601 10.612 1.00 33.34  ? 186 ILE B CG1 1 ? 
ATOM   3723 C CG2 . ILE B 1 163 ? -16.563 -31.070 13.071 1.00 31.84  ? 186 ILE B CG2 1 ? 
ATOM   3724 C CD1 . ILE B 1 163 ? -16.935 -33.006 10.666 1.00 30.10  ? 186 ILE B CD1 1 ? 
ATOM   3725 N N   . SER B 1 164 ? -14.700 -28.357 13.544 1.00 28.24  ? 187 SER B N   1 ? 
ATOM   3726 C CA  . SER B 1 164 ? -14.214 -27.809 14.830 1.00 28.79  ? 187 SER B CA  1 ? 
ATOM   3727 C C   . SER B 1 164 ? -15.141 -28.227 15.975 1.00 27.48  ? 187 SER B C   1 ? 
ATOM   3728 O O   . SER B 1 164 ? -16.354 -28.229 15.784 1.00 26.49  ? 187 SER B O   1 ? 
ATOM   3729 C CB  . SER B 1 164 ? -14.100 -26.315 14.760 1.00 23.44  ? 187 SER B CB  1 ? 
ATOM   3730 O OG  . SER B 1 164 ? -13.156 -25.903 13.788 1.00 30.00  ? 187 SER B OG  1 ? 
ATOM   3731 N N   . ARG B 1 165 ? -14.555 -28.555 17.122 1.00 27.85  ? 188 ARG B N   1 ? 
ATOM   3732 C CA  . ARG B 1 165 ? -15.350 -28.908 18.318 1.00 22.87  ? 188 ARG B CA  1 ? 
ATOM   3733 C C   . ARG B 1 165 ? -14.783 -28.129 19.508 1.00 22.54  ? 188 ARG B C   1 ? 
ATOM   3734 O O   . ARG B 1 165 ? -13.677 -28.443 19.944 1.00 20.71  ? 188 ARG B O   1 ? 
ATOM   3735 C CB  . ARG B 1 165 ? -15.326 -30.410 18.606 1.00 22.20  ? 188 ARG B CB  1 ? 
ATOM   3736 C CG  . ARG B 1 165 ? -16.074 -31.272 17.601 1.00 30.67  ? 188 ARG B CG  1 ? 
ATOM   3737 C CD  . ARG B 1 165 ? -17.439 -31.675 18.126 1.00 34.78  ? 188 ARG B CD  1 ? 
ATOM   3738 N NE  . ARG B 1 165 ? -18.354 -30.539 18.266 1.00 30.07  ? 188 ARG B NE  1 ? 
ATOM   3739 C CZ  . ARG B 1 165 ? -19.033 -29.984 17.272 1.00 35.06  ? 188 ARG B CZ  1 ? 
ATOM   3740 N NH1 . ARG B 1 165 ? -19.063 -30.556 16.083 1.00 30.64  ? 188 ARG B NH1 1 ? 
ATOM   3741 N NH2 . ARG B 1 165 ? -19.685 -28.855 17.472 1.00 33.24  ? 188 ARG B NH2 1 ? 
ATOM   3742 N N   . LYS B 1 166 ? -15.515 -27.112 19.955 1.00 19.81  ? 189 LYS B N   1 ? 
ATOM   3743 C CA  . LYS B 1 166 ? -15.093 -26.354 21.146 1.00 18.63  ? 189 LYS B CA  1 ? 
ATOM   3744 C C   . LYS B 1 166 ? -15.219 -27.278 22.364 1.00 21.22  ? 189 LYS B C   1 ? 
ATOM   3745 O O   . LYS B 1 166 ? -16.321 -27.739 22.644 1.00 21.37  ? 189 LYS B O   1 ? 
ATOM   3746 C CB  . LYS B 1 166 ? -15.926 -25.079 21.276 1.00 17.40  ? 189 LYS B CB  1 ? 
ATOM   3747 C CG  . LYS B 1 166 ? -15.722 -24.080 20.161 1.00 18.27  ? 189 LYS B CG  1 ? 
ATOM   3748 C CD  . LYS B 1 166 ? -16.636 -22.872 20.311 1.00 23.56  ? 189 LYS B CD  1 ? 
ATOM   3749 C CE  . LYS B 1 166 ? -16.637 -21.997 19.110 1.00 21.52  ? 189 LYS B CE  1 ? 
ATOM   3750 N NZ  . LYS B 1 166 ? -17.561 -20.879 19.287 1.00 23.73  ? 189 LYS B NZ  1 ? 
ATOM   3751 N N   . MET B 1 167 ? -14.093 -27.570 23.010 1.00 19.96  ? 190 MET B N   1 ? 
ATOM   3752 C CA  . MET B 1 167 ? -14.122 -28.385 24.247 1.00 20.26  ? 190 MET B CA  1 ? 
ATOM   3753 C C   . MET B 1 167 ? -13.203 -27.759 25.300 1.00 22.29  ? 190 MET B C   1 ? 
ATOM   3754 O O   . MET B 1 167 ? -12.191 -27.171 24.935 1.00 19.70  ? 190 MET B O   1 ? 
ATOM   3755 C CB  . MET B 1 167 ? -13.667 -29.829 24.014 1.00 19.01  ? 190 MET B CB  1 ? 
ATOM   3756 C CG  . MET B 1 167 ? -14.195 -30.446 22.743 1.00 25.05  ? 190 MET B CG  1 ? 
ATOM   3757 S SD  . MET B 1 167 ? -13.546 -32.106 22.479 1.00 26.71  ? 190 MET B SD  1 ? 
ATOM   3758 C CE  . MET B 1 167 ? -13.971 -32.884 24.040 1.00 27.17  ? 190 MET B CE  1 ? 
ATOM   3759 N N   . SER B 1 168 ? -13.580 -27.902 26.558 1.00 17.47  ? 191 SER B N   1 ? 
ATOM   3760 C CA  . SER B 1 168 ? -12.702 -27.424 27.646 1.00 22.95  ? 191 SER B CA  1 ? 
ATOM   3761 C C   . SER B 1 168 ? -11.372 -28.197 27.637 1.00 20.31  ? 191 SER B C   1 ? 
ATOM   3762 O O   . SER B 1 168 ? -11.383 -29.384 27.347 1.00 19.58  ? 191 SER B O   1 ? 
ATOM   3763 C CB  . SER B 1 168 ? -13.414 -27.571 28.957 1.00 24.11  ? 191 SER B CB  1 ? 
ATOM   3764 O OG  . SER B 1 168 ? -14.644 -26.863 28.945 1.00 31.14  ? 191 SER B OG  1 ? 
ATOM   3765 N N   . PHE B 1 169 ? -10.284 -27.529 27.999 1.00 19.89  ? 192 PHE B N   1 ? 
ATOM   3766 C CA  . PHE B 1 169 ? -8.941  -28.164 28.043 1.00 18.15  ? 192 PHE B CA  1 ? 
ATOM   3767 C C   . PHE B 1 169 ? -8.946  -29.509 28.787 1.00 17.81  ? 192 PHE B C   1 ? 
ATOM   3768 O O   . PHE B 1 169 ? -8.202  -30.404 28.406 1.00 20.32  ? 192 PHE B O   1 ? 
ATOM   3769 C CB  . PHE B 1 169 ? -7.979  -27.221 28.755 1.00 16.07  ? 192 PHE B CB  1 ? 
ATOM   3770 C CG  . PHE B 1 169 ? -6.524  -27.642 28.661 1.00 19.24  ? 192 PHE B CG  1 ? 
ATOM   3771 C CD1 . PHE B 1 169 ? -5.918  -27.824 27.426 1.00 15.98  ? 192 PHE B CD1 1 ? 
ATOM   3772 C CD2 . PHE B 1 169 ? -5.775  -27.864 29.808 1.00 15.50  ? 192 PHE B CD2 1 ? 
ATOM   3773 C CE1 . PHE B 1 169 ? -4.594  -28.206 27.344 1.00 17.88  ? 192 PHE B CE1 1 ? 
ATOM   3774 C CE2 . PHE B 1 169 ? -4.452  -28.248 29.716 1.00 19.45  ? 192 PHE B CE2 1 ? 
ATOM   3775 C CZ  . PHE B 1 169 ? -3.867  -28.415 28.487 1.00 17.63  ? 192 PHE B CZ  1 ? 
ATOM   3776 N N   . ALA B 1 170 ? -9.750  -29.620 29.836 1.00 17.94  ? 193 ALA B N   1 ? 
ATOM   3777 C CA  . ALA B 1 170 ? -9.724  -30.854 30.659 1.00 20.42  ? 193 ALA B CA  1 ? 
ATOM   3778 C C   . ALA B 1 170 ? -10.258 -32.053 29.874 1.00 22.22  ? 193 ALA B C   1 ? 
ATOM   3779 O O   . ALA B 1 170 ? -9.926  -33.186 30.228 1.00 23.49  ? 193 ALA B O   1 ? 
ATOM   3780 C CB  . ALA B 1 170 ? -10.514 -30.632 31.911 1.00 21.19  ? 193 ALA B CB  1 ? 
ATOM   3781 N N   . GLU B 1 171 ? -11.029 -31.808 28.821 1.00 18.29  ? 194 GLU B N   1 ? 
ATOM   3782 C CA  . GLU B 1 171 ? -11.692 -32.937 28.124 1.00 23.40  ? 194 GLU B CA  1 ? 
ATOM   3783 C C   . GLU B 1 171 ? -10.888 -33.392 26.899 1.00 22.51  ? 194 GLU B C   1 ? 
ATOM   3784 O O   . GLU B 1 171 ? -11.282 -34.405 26.309 1.00 24.65  ? 194 GLU B O   1 ? 
ATOM   3785 C CB  . GLU B 1 171 ? -13.084 -32.459 27.705 1.00 24.14  ? 194 GLU B CB  1 ? 
ATOM   3786 C CG  . GLU B 1 171 ? -13.941 -31.934 28.849 1.00 29.00  ? 194 GLU B CG  1 ? 
ATOM   3787 C CD  . GLU B 1 171 ? -15.247 -31.337 28.355 1.00 47.22  ? 194 GLU B CD  1 ? 
ATOM   3788 O OE1 . GLU B 1 171 ? -16.061 -30.933 29.204 1.00 49.01  ? 194 GLU B OE1 1 ? 
ATOM   3789 O OE2 . GLU B 1 171 ? -15.451 -31.278 27.127 1.00 44.75  ? 194 GLU B OE2 1 ? 
ATOM   3790 N N   . VAL B 1 172 ? -9.790  -32.715 26.583 1.00 20.07  ? 195 VAL B N   1 ? 
ATOM   3791 C CA  . VAL B 1 172 ? -9.058  -32.984 25.313 1.00 18.32  ? 195 VAL B CA  1 ? 
ATOM   3792 C C   . VAL B 1 172 ? -8.569  -34.439 25.239 1.00 21.65  ? 195 VAL B C   1 ? 
ATOM   3793 O O   . VAL B 1 172 ? -8.806  -35.078 24.215 1.00 22.23  ? 195 VAL B O   1 ? 
ATOM   3794 C CB  . VAL B 1 172 ? -7.904  -31.985 25.132 1.00 18.89  ? 195 VAL B CB  1 ? 
ATOM   3795 C CG1 . VAL B 1 172 ? -7.124  -32.236 23.851 1.00 23.20  ? 195 VAL B CG1 1 ? 
ATOM   3796 C CG2 . VAL B 1 172 ? -8.392  -30.550 25.194 1.00 21.66  ? 195 VAL B CG2 1 ? 
ATOM   3797 N N   . TYR B 1 173 ? -7.930  -34.932 26.294 1.00 18.59  ? 196 TYR B N   1 ? 
ATOM   3798 C CA  . TYR B 1 173 ? -7.329  -36.293 26.197 1.00 21.31  ? 196 TYR B CA  1 ? 
ATOM   3799 C C   . TYR B 1 173 ? -8.405  -37.316 25.874 1.00 20.68  ? 196 TYR B C   1 ? 
ATOM   3800 O O   . TYR B 1 173 ? -8.254  -38.097 24.934 1.00 25.24  ? 196 TYR B O   1 ? 
ATOM   3801 C CB  . TYR B 1 173 ? -6.595  -36.684 27.482 1.00 18.19  ? 196 TYR B CB  1 ? 
ATOM   3802 C CG  . TYR B 1 173 ? -5.853  -38.012 27.473 1.00 22.38  ? 196 TYR B CG  1 ? 
ATOM   3803 C CD1 . TYR B 1 173 ? -6.525  -39.216 27.647 1.00 22.34  ? 196 TYR B CD1 1 ? 
ATOM   3804 C CD2 . TYR B 1 173 ? -4.473  -38.058 27.325 1.00 22.34  ? 196 TYR B CD2 1 ? 
ATOM   3805 C CE1 . TYR B 1 173 ? -5.853  -40.425 27.646 1.00 23.59  ? 196 TYR B CE1 1 ? 
ATOM   3806 C CE2 . TYR B 1 173 ? -3.791  -39.261 27.331 1.00 24.50  ? 196 TYR B CE2 1 ? 
ATOM   3807 C CZ  . TYR B 1 173 ? -4.480  -40.447 27.486 1.00 23.74  ? 196 TYR B CZ  1 ? 
ATOM   3808 O OH  . TYR B 1 173 ? -3.804  -41.627 27.480 1.00 26.32  ? 196 TYR B OH  1 ? 
ATOM   3809 N N   . GLN B 1 174 ? -9.462  -37.325 26.672 1.00 20.39  ? 197 GLN B N   1 ? 
ATOM   3810 C CA  . GLN B 1 174 ? -10.507 -38.361 26.490 1.00 28.08  ? 197 GLN B CA  1 ? 
ATOM   3811 C C   . GLN B 1 174 ? -11.204 -38.152 25.138 1.00 24.40  ? 197 GLN B C   1 ? 
ATOM   3812 O O   . GLN B 1 174 ? -11.534 -39.143 24.507 1.00 24.13  ? 197 GLN B O   1 ? 
ATOM   3813 C CB  . GLN B 1 174 ? -11.454 -38.334 27.682 1.00 26.87  ? 197 GLN B CB  1 ? 
ATOM   3814 C CG  . GLN B 1 174 ? -12.806 -38.967 27.388 1.00 48.10  ? 197 GLN B CG  1 ? 
ATOM   3815 C CD  . GLN B 1 174 ? -13.509 -39.470 28.625 1.00 53.25  ? 197 GLN B CD  1 ? 
ATOM   3816 O OE1 . GLN B 1 174 ? -12.948 -39.482 29.726 1.00 46.85  ? 197 GLN B OE1 1 ? 
ATOM   3817 N NE2 . GLN B 1 174 ? -14.749 -39.896 28.443 1.00 48.22  ? 197 GLN B NE2 1 ? 
ATOM   3818 N N   . GLY B 1 175 ? -11.359 -36.893 24.720 1.00 20.00  ? 198 GLY B N   1 ? 
ATOM   3819 C CA  . GLY B 1 175 ? -11.964 -36.615 23.406 1.00 21.12  ? 198 GLY B CA  1 ? 
ATOM   3820 C C   . GLY B 1 175 ? -11.184 -37.272 22.289 1.00 22.99  ? 198 GLY B C   1 ? 
ATOM   3821 O O   . GLY B 1 175 ? -11.795 -37.895 21.413 1.00 22.29  ? 198 GLY B O   1 ? 
ATOM   3822 N N   . LEU B 1 176 ? -9.868  -37.141 22.335 1.00 24.00  ? 199 LEU B N   1 ? 
ATOM   3823 C CA  . LEU B 1 176 ? -9.004  -37.726 21.281 1.00 24.06  ? 199 LEU B CA  1 ? 
ATOM   3824 C C   . LEU B 1 176 ? -8.977  -39.253 21.428 1.00 25.28  ? 199 LEU B C   1 ? 
ATOM   3825 O O   . LEU B 1 176 ? -8.995  -39.943 20.418 1.00 27.08  ? 199 LEU B O   1 ? 
ATOM   3826 C CB  . LEU B 1 176 ? -7.616  -37.099 21.369 1.00 26.28  ? 199 LEU B CB  1 ? 
ATOM   3827 C CG  . LEU B 1 176 ? -7.539  -35.593 21.112 1.00 24.09  ? 199 LEU B CG  1 ? 
ATOM   3828 C CD1 . LEU B 1 176 ? -6.284  -35.040 21.735 1.00 21.18  ? 199 LEU B CD1 1 ? 
ATOM   3829 C CD2 . LEU B 1 176 ? -7.584  -35.274 19.636 1.00 21.36  ? 199 LEU B CD2 1 ? 
ATOM   3830 N N   . GLN B 1 177 ? -8.955  -39.736 22.660 1.00 26.62  ? 200 GLN B N   1 ? 
ATOM   3831 C CA  . GLN B 1 177 ? -8.888  -41.196 22.903 1.00 30.79  ? 200 GLN B CA  1 ? 
ATOM   3832 C C   . GLN B 1 177 ? -10.154 -41.866 22.387 1.00 28.75  ? 200 GLN B C   1 ? 
ATOM   3833 O O   . GLN B 1 177 ? -10.013 -42.958 21.823 1.00 39.37  ? 200 GLN B O   1 ? 
ATOM   3834 C CB  . GLN B 1 177 ? -8.788  -41.408 24.409 1.00 26.03  ? 200 GLN B CB  1 ? 
ATOM   3835 C CG  . GLN B 1 177 ? -8.787  -42.850 24.890 1.00 29.61  ? 200 GLN B CG  1 ? 
ATOM   3836 C CD  . GLN B 1 177 ? -8.688  -42.930 26.395 1.00 32.96  ? 200 GLN B CD  1 ? 
ATOM   3837 O OE1 . GLN B 1 177 ? -9.417  -42.249 27.123 1.00 36.88  ? 200 GLN B OE1 1 ? 
ATOM   3838 N NE2 . GLN B 1 177 ? -7.759  -43.741 26.876 1.00 40.77  ? 200 GLN B NE2 1 ? 
ATOM   3839 N N   . THR B 1 178 ? -11.313 -41.226 22.535 1.00 26.16  ? 201 THR B N   1 ? 
ATOM   3840 C CA  . THR B 1 178 ? -12.620 -41.844 22.212 1.00 28.25  ? 201 THR B CA  1 ? 
ATOM   3841 C C   . THR B 1 178 ? -13.039 -41.625 20.770 1.00 28.73  ? 201 THR B C   1 ? 
ATOM   3842 O O   . THR B 1 178 ? -14.058 -42.177 20.371 1.00 27.70  ? 201 THR B O   1 ? 
ATOM   3843 C CB  . THR B 1 178 ? -13.662 -41.253 23.159 1.00 26.93  ? 201 THR B CB  1 ? 
ATOM   3844 O OG1 . THR B 1 178 ? -13.536 -39.839 23.087 1.00 25.90  ? 201 THR B OG1 1 ? 
ATOM   3845 C CG2 . THR B 1 178 ? -13.474 -41.749 24.582 1.00 25.74  ? 201 THR B CG2 1 ? 
ATOM   3846 N N   . GLY B 1 179 ? -12.315 -40.789 20.040 1.00 30.88  ? 202 GLY B N   1 ? 
ATOM   3847 C CA  . GLY B 1 179 ? -12.688 -40.492 18.647 1.00 26.47  ? 202 GLY B CA  1 ? 
ATOM   3848 C C   . GLY B 1 179 ? -13.677 -39.351 18.534 1.00 29.52  ? 202 GLY B C   1 ? 
ATOM   3849 O O   . GLY B 1 179 ? -14.002 -38.971 17.407 1.00 25.37  ? 202 GLY B O   1 ? 
ATOM   3850 N N   . VAL B 1 180 ? -14.150 -38.811 19.653 1.00 21.93  ? 203 VAL B N   1 ? 
ATOM   3851 C CA  . VAL B 1 180 ? -15.023 -37.599 19.581 1.00 24.31  ? 203 VAL B CA  1 ? 
ATOM   3852 C C   . VAL B 1 180 ? -14.296 -36.562 18.715 1.00 18.64  ? 203 VAL B C   1 ? 
ATOM   3853 O O   . VAL B 1 180 ? -14.966 -35.862 17.947 1.00 21.18  ? 203 VAL B O   1 ? 
ATOM   3854 C CB  . VAL B 1 180 ? -15.335 -37.039 20.977 1.00 20.74  ? 203 VAL B CB  1 ? 
ATOM   3855 C CG1 . VAL B 1 180 ? -15.965 -35.654 20.921 1.00 21.21  ? 203 VAL B CG1 1 ? 
ATOM   3856 C CG2 . VAL B 1 180 ? -16.178 -38.000 21.797 1.00 20.18  ? 203 VAL B CG2 1 ? 
ATOM   3857 N N   . VAL B 1 181 ? -12.990 -36.443 18.903 1.00 18.61  ? 204 VAL B N   1 ? 
ATOM   3858 C CA  . VAL B 1 181 ? -12.139 -35.563 18.052 1.00 20.53  ? 204 VAL B CA  1 ? 
ATOM   3859 C C   . VAL B 1 181 ? -10.940 -36.411 17.582 1.00 19.18  ? 204 VAL B C   1 ? 
ATOM   3860 O O   . VAL B 1 181 ? -10.637 -37.408 18.237 1.00 26.63  ? 204 VAL B O   1 ? 
ATOM   3861 C CB  . VAL B 1 181 ? -11.716 -34.222 18.697 1.00 17.62  ? 204 VAL B CB  1 ? 
ATOM   3862 C CG1 . VAL B 1 181 ? -12.803 -33.167 18.571 1.00 15.33  ? 204 VAL B CG1 1 ? 
ATOM   3863 C CG2 . VAL B 1 181 ? -11.253 -34.369 20.139 1.00 15.65  ? 204 VAL B CG2 1 ? 
ATOM   3864 N N   . ASN B 1 182 ? -10.340 -36.059 16.456 1.00 18.37  ? 205 ASN B N   1 ? 
ATOM   3865 C CA  . ASN B 1 182 ? -9.226  -36.853 15.879 1.00 23.32  ? 205 ASN B CA  1 ? 
ATOM   3866 C C   . ASN B 1 182 ? -7.916  -36.062 15.939 1.00 22.13  ? 205 ASN B C   1 ? 
ATOM   3867 O O   . ASN B 1 182 ? -6.865  -36.675 15.796 1.00 28.05  ? 205 ASN B O   1 ? 
ATOM   3868 C CB  . ASN B 1 182 ? -9.473  -37.231 14.423 1.00 27.71  ? 205 ASN B CB  1 ? 
ATOM   3869 C CG  . ASN B 1 182 ? -10.905 -37.581 14.107 1.00 38.10  ? 205 ASN B CG  1 ? 
ATOM   3870 O OD1 . ASN B 1 182 ? -11.503 -36.979 13.213 1.00 36.36  ? 205 ASN B OD1 1 ? 
ATOM   3871 N ND2 . ASN B 1 182 ? -11.461 -38.560 14.803 1.00 61.95  ? 205 ASN B ND2 1 ? 
ATOM   3872 N N   . GLY B 1 183 ? -8.003  -34.751 16.109 1.00 21.81  ? 206 GLY B N   1 ? 
ATOM   3873 C CA  . GLY B 1 183 ? -6.810  -33.904 16.110 1.00 19.14  ? 206 GLY B CA  1 ? 
ATOM   3874 C C   . GLY B 1 183 ? -7.031  -32.653 16.924 1.00 22.05  ? 206 GLY B C   1 ? 
ATOM   3875 O O   . GLY B 1 183 ? -8.160  -32.430 17.354 1.00 24.00  ? 206 GLY B O   1 ? 
ATOM   3876 N N   . THR B 1 184 ? -5.965  -31.904 17.161 1.00 21.38  ? 207 THR B N   1 ? 
ATOM   3877 C CA  . THR B 1 184 ? -6.098  -30.625 17.876 1.00 19.99  ? 207 THR B CA  1 ? 
ATOM   3878 C C   . THR B 1 184 ? -4.900  -29.752 17.593 1.00 20.13  ? 207 THR B C   1 ? 
ATOM   3879 O O   . THR B 1 184 ? -4.126  -30.079 16.696 1.00 17.71  ? 207 THR B O   1 ? 
ATOM   3880 C CB  . THR B 1 184 ? -6.307  -30.851 19.380 1.00 20.07  ? 207 THR B CB  1 ? 
ATOM   3881 O OG1 . THR B 1 184 ? -6.666  -29.597 19.953 1.00 20.38  ? 207 THR B OG1 1 ? 
ATOM   3882 C CG2 . THR B 1 184 ? -5.086  -31.423 20.076 1.00 18.81  ? 207 THR B CG2 1 ? 
ATOM   3883 N N   . GLU B 1 185 ? -4.810  -28.651 18.318 1.00 17.41  ? 208 GLU B N   1 ? 
ATOM   3884 C CA  . GLU B 1 185 ? -3.675  -27.722 18.200 1.00 19.27  ? 208 GLU B CA  1 ? 
ATOM   3885 C C   . GLU B 1 185 ? -3.326  -27.304 19.636 1.00 21.70  ? 208 GLU B C   1 ? 
ATOM   3886 O O   . GLU B 1 185 ? -4.251  -27.198 20.449 1.00 17.28  ? 208 GLU B O   1 ? 
ATOM   3887 C CB  . GLU B 1 185 ? -4.000  -26.478 17.382 1.00 17.33  ? 208 GLU B CB  1 ? 
ATOM   3888 C CG  . GLU B 1 185 ? -5.269  -25.767 17.841 1.00 21.43  ? 208 GLU B CG  1 ? 
ATOM   3889 C CD  . GLU B 1 185 ? -5.458  -24.362 17.305 1.00 23.16  ? 208 GLU B CD  1 ? 
ATOM   3890 O OE1 . GLU B 1 185 ? -6.205  -23.593 17.932 1.00 23.80  ? 208 GLU B OE1 1 ? 
ATOM   3891 O OE2 . GLU B 1 185 ? -4.859  -24.035 16.269 1.00 21.24  ? 208 GLU B OE2 1 ? 
ATOM   3892 N N   . ASN B 1 186 ? -2.039  -27.141 19.914 1.00 18.84  ? 209 ASN B N   1 ? 
ATOM   3893 C CA  . ASN B 1 186 ? -1.603  -26.685 21.262 1.00 21.67  ? 209 ASN B CA  1 ? 
ATOM   3894 C C   . ASN B 1 186 ? -0.078  -26.517 21.327 1.00 22.47  ? 209 ASN B C   1 ? 
ATOM   3895 O O   . ASN B 1 186 ? 0.603   -26.788 20.332 1.00 22.32  ? 209 ASN B O   1 ? 
ATOM   3896 C CB  . ASN B 1 186 ? -2.034  -27.626 22.378 1.00 16.26  ? 209 ASN B CB  1 ? 
ATOM   3897 C CG  . ASN B 1 186 ? -2.611  -26.865 23.548 1.00 17.37  ? 209 ASN B CG  1 ? 
ATOM   3898 O OD1 . ASN B 1 186 ? -1.969  -25.956 24.080 1.00 13.40  ? 209 ASN B OD1 1 ? 
ATOM   3899 N ND2 . ASN B 1 186 ? -3.823  -27.212 23.950 1.00 16.52  ? 209 ASN B ND2 1 ? 
ATOM   3900 N N   . THR B 1 187 ? 0.412   -26.101 22.486 1.00 21.84  ? 210 THR B N   1 ? 
ATOM   3901 C CA  . THR B 1 187 ? 1.855   -25.967 22.708 1.00 18.58  ? 210 THR B CA  1 ? 
ATOM   3902 C C   . THR B 1 187 ? 2.433   -27.314 23.066 1.00 16.95  ? 210 THR B C   1 ? 
ATOM   3903 O O   . THR B 1 187 ? 1.720   -28.146 23.634 1.00 21.55  ? 210 THR B O   1 ? 
ATOM   3904 C CB  . THR B 1 187 ? 2.089   -24.952 23.827 1.00 18.21  ? 210 THR B CB  1 ? 
ATOM   3905 O OG1 . THR B 1 187 ? 1.594   -25.529 25.030 1.00 21.29  ? 210 THR B OG1 1 ? 
ATOM   3906 C CG2 . THR B 1 187 ? 1.399   -23.628 23.555 1.00 21.14  ? 210 THR B CG2 1 ? 
ATOM   3907 N N   . TRP B 1 188 ? 3.718   -27.498 22.794 1.00 18.60  ? 211 TRP B N   1 ? 
ATOM   3908 C CA  . TRP B 1 188 ? 4.385   -28.745 23.221 1.00 18.95  ? 211 TRP B CA  1 ? 
ATOM   3909 C C   . TRP B 1 188 ? 4.117   -28.986 24.712 1.00 18.41  ? 211 TRP B C   1 ? 
ATOM   3910 O O   . TRP B 1 188 ? 3.838   -30.129 25.081 1.00 17.44  ? 211 TRP B O   1 ? 
ATOM   3911 C CB  . TRP B 1 188 ? 5.894   -28.658 22.944 1.00 16.83  ? 211 TRP B CB  1 ? 
ATOM   3912 C CG  . TRP B 1 188 ? 6.301   -28.435 21.513 1.00 15.40  ? 211 TRP B CG  1 ? 
ATOM   3913 C CD1 . TRP B 1 188 ? 7.075   -27.420 21.037 1.00 16.63  ? 211 TRP B CD1 1 ? 
ATOM   3914 C CD2 . TRP B 1 188 ? 6.000   -29.274 20.378 1.00 19.04  ? 211 TRP B CD2 1 ? 
ATOM   3915 N NE1 . TRP B 1 188 ? 7.254   -27.549 19.688 1.00 20.00  ? 211 TRP B NE1 1 ? 
ATOM   3916 C CE2 . TRP B 1 188 ? 6.614   -28.679 19.256 1.00 18.17  ? 211 TRP B CE2 1 ? 
ATOM   3917 C CE3 . TRP B 1 188 ? 5.274   -30.456 20.199 1.00 20.83  ? 211 TRP B CE3 1 ? 
ATOM   3918 C CZ2 . TRP B 1 188 ? 6.523   -29.230 17.981 1.00 18.67  ? 211 TRP B CZ2 1 ? 
ATOM   3919 C CZ3 . TRP B 1 188 ? 5.186   -30.997 18.938 1.00 18.94  ? 211 TRP B CZ3 1 ? 
ATOM   3920 C CH2 . TRP B 1 188 ? 5.802   -30.391 17.847 1.00 18.18  ? 211 TRP B CH2 1 ? 
ATOM   3921 N N   . SER B 1 189 ? 4.220   -27.934 25.529 1.00 15.85  ? 212 SER B N   1 ? 
ATOM   3922 C CA  . SER B 1 189 ? 4.037   -28.074 26.999 1.00 19.04  ? 212 SER B CA  1 ? 
ATOM   3923 C C   . SER B 1 189 ? 2.679   -28.705 27.344 1.00 19.27  ? 212 SER B C   1 ? 
ATOM   3924 O O   . SER B 1 189 ? 2.658   -29.619 28.155 1.00 18.93  ? 212 SER B O   1 ? 
ATOM   3925 C CB  . SER B 1 189 ? 4.232   -26.755 27.749 1.00 15.76  ? 212 SER B CB  1 ? 
ATOM   3926 O OG  . SER B 1 189 ? 3.773   -26.851 29.084 1.00 16.87  ? 212 SER B OG  1 ? 
ATOM   3927 N N   . ASN B 1 190 ? 1.594   -28.195 26.758 1.00 18.18  ? 213 ASN B N   1 ? 
ATOM   3928 C CA  . ASN B 1 190 ? 0.228   -28.712 27.054 1.00 19.69  ? 213 ASN B CA  1 ? 
ATOM   3929 C C   . ASN B 1 190 ? 0.096   -30.171 26.587 1.00 18.43  ? 213 ASN B C   1 ? 
ATOM   3930 O O   . ASN B 1 190 ? -0.423  -30.993 27.328 1.00 20.60  ? 213 ASN B O   1 ? 
ATOM   3931 C CB  . ASN B 1 190 ? -0.842  -27.785 26.486 1.00 20.14  ? 213 ASN B CB  1 ? 
ATOM   3932 C CG  . ASN B 1 190 ? -1.119  -26.617 27.405 1.00 17.06  ? 213 ASN B CG  1 ? 
ATOM   3933 O OD1 . ASN B 1 190 ? -0.920  -26.723 28.617 1.00 14.80  ? 213 ASN B OD1 1 ? 
ATOM   3934 N ND2 . ASN B 1 190 ? -1.580  -25.506 26.852 1.00 18.55  ? 213 ASN B ND2 1 ? 
ATOM   3935 N N   . TYR B 1 191 ? 0.585   -30.456 25.395 1.00 18.91  ? 214 TYR B N   1 ? 
ATOM   3936 C CA  . TYR B 1 191 ? 0.496   -31.835 24.857 1.00 19.01  ? 214 TYR B CA  1 ? 
ATOM   3937 C C   . TYR B 1 191 ? 1.214   -32.813 25.774 1.00 18.39  ? 214 TYR B C   1 ? 
ATOM   3938 O O   . TYR B 1 191 ? 0.666   -33.873 26.056 1.00 21.64  ? 214 TYR B O   1 ? 
ATOM   3939 C CB  . TYR B 1 191 ? 1.145   -31.835 23.477 1.00 18.81  ? 214 TYR B CB  1 ? 
ATOM   3940 C CG  . TYR B 1 191 ? 0.300   -31.419 22.286 1.00 20.54  ? 214 TYR B CG  1 ? 
ATOM   3941 C CD1 . TYR B 1 191 ? -0.887  -32.072 21.990 1.00 19.23  ? 214 TYR B CD1 1 ? 
ATOM   3942 C CD2 . TYR B 1 191 ? 0.720   -30.409 21.431 1.00 19.36  ? 214 TYR B CD2 1 ? 
ATOM   3943 C CE1 . TYR B 1 191 ? -1.646  -31.715 20.892 1.00 19.03  ? 214 TYR B CE1 1 ? 
ATOM   3944 C CE2 . TYR B 1 191 ? -0.032  -30.044 20.329 1.00 25.08  ? 214 TYR B CE2 1 ? 
ATOM   3945 C CZ  . TYR B 1 191 ? -1.220  -30.697 20.062 1.00 23.01  ? 214 TYR B CZ  1 ? 
ATOM   3946 O OH  . TYR B 1 191 ? -1.964  -30.356 18.976 1.00 21.24  ? 214 TYR B OH  1 ? 
ATOM   3947 N N   . GLU B 1 192 ? 2.431   -32.461 26.193 1.00 16.12  ? 215 GLU B N   1 ? 
ATOM   3948 C CA  . GLU B 1 192 ? 3.263   -33.409 26.973 1.00 18.31  ? 215 GLU B CA  1 ? 
ATOM   3949 C C   . GLU B 1 192 ? 2.786   -33.474 28.420 1.00 16.53  ? 215 GLU B C   1 ? 
ATOM   3950 O O   . GLU B 1 192 ? 2.711   -34.578 28.955 1.00 18.38  ? 215 GLU B O   1 ? 
ATOM   3951 C CB  . GLU B 1 192 ? 4.731   -32.986 26.954 1.00 21.59  ? 215 GLU B CB  1 ? 
ATOM   3952 C CG  . GLU B 1 192 ? 5.702   -34.092 27.355 1.00 23.24  ? 215 GLU B CG  1 ? 
ATOM   3953 C CD  . GLU B 1 192 ? 5.892   -34.265 28.850 1.00 24.60  ? 215 GLU B CD  1 ? 
ATOM   3954 O OE1 . GLU B 1 192 ? 6.183   -35.390 29.271 1.00 29.36  ? 215 GLU B OE1 1 ? 
ATOM   3955 O OE2 . GLU B 1 192 ? 5.729   -33.284 29.594 1.00 28.96  ? 215 GLU B OE2 1 ? 
ATOM   3956 N N   . SER B 1 193 ? 2.473   -32.320 29.002 1.00 14.75  ? 216 SER B N   1 ? 
ATOM   3957 C CA  . SER B 1 193 ? 2.079   -32.259 30.435 1.00 19.80  ? 216 SER B CA  1 ? 
ATOM   3958 C C   . SER B 1 193 ? 0.768   -33.021 30.669 1.00 19.51  ? 216 SER B C   1 ? 
ATOM   3959 O O   . SER B 1 193 ? 0.543   -33.431 31.807 1.00 19.31  ? 216 SER B O   1 ? 
ATOM   3960 C CB  . SER B 1 193 ? 1.949   -30.824 30.898 1.00 19.06  ? 216 SER B CB  1 ? 
ATOM   3961 O OG  . SER B 1 193 ? 1.000   -30.101 30.135 1.00 21.35  ? 216 SER B OG  1 ? 
ATOM   3962 N N   . GLN B 1 194 ? -0.064  -33.148 29.634 1.00 16.74  ? 217 GLN B N   1 ? 
ATOM   3963 C CA  . GLN B 1 194 ? -1.354  -33.887 29.739 1.00 21.61  ? 217 GLN B CA  1 ? 
ATOM   3964 C C   . GLN B 1 194 ? -1.254  -35.251 29.022 1.00 22.27  ? 217 GLN B C   1 ? 
ATOM   3965 O O   . GLN B 1 194 ? -2.295  -35.895 28.863 1.00 24.20  ? 217 GLN B O   1 ? 
ATOM   3966 C CB  . GLN B 1 194 ? -2.509  -33.049 29.190 1.00 20.26  ? 217 GLN B CB  1 ? 
ATOM   3967 C CG  . GLN B 1 194 ? -2.658  -31.684 29.855 1.00 17.67  ? 217 GLN B CG  1 ? 
ATOM   3968 C CD  . GLN B 1 194 ? -3.193  -31.760 31.268 1.00 24.14  ? 217 GLN B CD  1 ? 
ATOM   3969 O OE1 . GLN B 1 194 ? -3.761  -32.771 31.688 1.00 23.35  ? 217 GLN B OE1 1 ? 
ATOM   3970 N NE2 . GLN B 1 194 ? -3.006  -30.688 32.022 1.00 22.49  ? 217 GLN B NE2 1 ? 
ATOM   3971 N N   . LYS B 1 195 ? -0.053  -35.664 28.634 1.00 19.79  ? 218 LYS B N   1 ? 
ATOM   3972 C CA  . LYS B 1 195 ? 0.181   -36.983 27.984 1.00 22.92  ? 218 LYS B CA  1 ? 
ATOM   3973 C C   . LYS B 1 195 ? -0.737  -37.194 26.769 1.00 26.70  ? 218 LYS B C   1 ? 
ATOM   3974 O O   . LYS B 1 195 ? -1.034  -38.342 26.460 1.00 24.94  ? 218 LYS B O   1 ? 
ATOM   3975 C CB  . LYS B 1 195 ? 0.045   -38.080 29.037 1.00 23.39  ? 218 LYS B CB  1 ? 
ATOM   3976 C CG  . LYS B 1 195 ? 1.030   -37.931 30.175 1.00 28.58  ? 218 LYS B CG  1 ? 
ATOM   3977 C CD  . LYS B 1 195 ? 0.400   -38.226 31.527 1.00 40.96  ? 218 LYS B CD  1 ? 
ATOM   3978 C CE  . LYS B 1 195 ? 0.913   -39.494 32.128 1.00 52.94  ? 218 LYS B CE  1 ? 
ATOM   3979 N NZ  . LYS B 1 195 ? 1.741   -40.265 31.198 1.00 53.87  ? 218 LYS B NZ  1 ? 
ATOM   3980 N N   . VAL B 1 196 ? -1.080  -36.115 26.063 1.00 26.12  ? 219 VAL B N   1 ? 
ATOM   3981 C CA  . VAL B 1 196 ? -1.959  -36.210 24.859 1.00 19.47  ? 219 VAL B CA  1 ? 
ATOM   3982 C C   . VAL B 1 196 ? -1.173  -36.874 23.717 1.00 24.70  ? 219 VAL B C   1 ? 
ATOM   3983 O O   . VAL B 1 196 ? -1.787  -37.458 22.826 1.00 22.25  ? 219 VAL B O   1 ? 
ATOM   3984 C CB  . VAL B 1 196 ? -2.501  -34.813 24.519 1.00 21.05  ? 219 VAL B CB  1 ? 
ATOM   3985 C CG1 . VAL B 1 196 ? -3.097  -34.718 23.123 1.00 22.93  ? 219 VAL B CG1 1 ? 
ATOM   3986 C CG2 . VAL B 1 196 ? -3.476  -34.308 25.573 1.00 19.53  ? 219 VAL B CG2 1 ? 
ATOM   3987 N N   . ASN B 1 197 ? 0.151   -36.808 23.778 1.00 25.53  ? 220 ASN B N   1 ? 
ATOM   3988 C CA  . ASN B 1 197 ? 0.996   -37.512 22.781 1.00 25.11  ? 220 ASN B CA  1 ? 
ATOM   3989 C C   . ASN B 1 197 ? 0.655   -39.010 22.809 1.00 26.02  ? 220 ASN B C   1 ? 
ATOM   3990 O O   . ASN B 1 197 ? 0.869   -39.673 21.795 1.00 30.84  ? 220 ASN B O   1 ? 
ATOM   3991 C CB  . ASN B 1 197 ? 2.473   -37.215 23.020 1.00 25.59  ? 220 ASN B CB  1 ? 
ATOM   3992 C CG  . ASN B 1 197 ? 2.925   -37.569 24.413 1.00 29.11  ? 220 ASN B CG  1 ? 
ATOM   3993 O OD1 . ASN B 1 197 ? 2.597   -36.861 25.367 1.00 30.61  ? 220 ASN B OD1 1 ? 
ATOM   3994 N ND2 . ASN B 1 197 ? 3.679   -38.649 24.546 1.00 31.89  ? 220 ASN B ND2 1 ? 
ATOM   3995 N N   . GLU B 1 198 ? 0.119   -39.501 23.919 1.00 22.87  ? 221 GLU B N   1 ? 
ATOM   3996 C CA  . GLU B 1 198 ? -0.277  -40.928 24.035 1.00 25.58  ? 221 GLU B CA  1 ? 
ATOM   3997 C C   . GLU B 1 198 ? -1.477  -41.235 23.120 1.00 26.52  ? 221 GLU B C   1 ? 
ATOM   3998 O O   . GLU B 1 198 ? -1.688  -42.413 22.821 1.00 24.24  ? 221 GLU B O   1 ? 
ATOM   3999 C CB  . GLU B 1 198 ? -0.647  -41.275 25.474 1.00 22.83  ? 221 GLU B CB  1 ? 
ATOM   4000 C CG  . GLU B 1 198 ? 0.500   -41.194 26.473 1.00 29.41  ? 221 GLU B CG  1 ? 
ATOM   4001 C CD  . GLU B 1 198 ? 0.058   -41.591 27.870 1.00 30.55  ? 221 GLU B CD  1 ? 
ATOM   4002 O OE1 . GLU B 1 198 ? 0.941   -41.835 28.708 1.00 34.59  ? 221 GLU B OE1 1 ? 
ATOM   4003 O OE2 . GLU B 1 198 ? -1.161  -41.652 28.124 1.00 27.41  ? 221 GLU B OE2 1 ? 
ATOM   4004 N N   . VAL B 1 199 ? -2.241  -40.211 22.728 1.00 21.21  ? 222 VAL B N   1 ? 
ATOM   4005 C CA  . VAL B 1 199 ? -3.463  -40.418 21.898 1.00 21.74  ? 222 VAL B CA  1 ? 
ATOM   4006 C C   . VAL B 1 199 ? -3.353  -39.621 20.587 1.00 23.06  ? 222 VAL B C   1 ? 
ATOM   4007 O O   . VAL B 1 199 ? -4.372  -39.432 19.925 1.00 23.34  ? 222 VAL B O   1 ? 
ATOM   4008 C CB  . VAL B 1 199 ? -4.715  -40.070 22.722 1.00 21.11  ? 222 VAL B CB  1 ? 
ATOM   4009 C CG1 . VAL B 1 199 ? -4.972  -41.111 23.801 1.00 18.15  ? 222 VAL B CG1 1 ? 
ATOM   4010 C CG2 . VAL B 1 199 ? -4.642  -38.681 23.337 1.00 18.09  ? 222 VAL B CG2 1 ? 
ATOM   4011 N N   . GLN B 1 200 ? -2.147  -39.183 20.244 1.00 24.87  ? 223 GLN B N   1 ? 
ATOM   4012 C CA  . GLN B 1 200 ? -1.909  -38.442 18.976 1.00 24.43  ? 223 GLN B CA  1 ? 
ATOM   4013 C C   . GLN B 1 200 ? -0.597  -38.955 18.365 1.00 29.72  ? 223 GLN B C   1 ? 
ATOM   4014 O O   . GLN B 1 200 ? 0.457   -38.684 18.940 1.00 28.93  ? 223 GLN B O   1 ? 
ATOM   4015 C CB  . GLN B 1 200 ? -1.901  -36.933 19.181 1.00 22.98  ? 223 GLN B CB  1 ? 
ATOM   4016 C CG  . GLN B 1 200 ? -3.242  -36.346 19.597 1.00 21.61  ? 223 GLN B CG  1 ? 
ATOM   4017 C CD  . GLN B 1 200 ? -4.177  -36.134 18.429 1.00 21.34  ? 223 GLN B CD  1 ? 
ATOM   4018 O OE1 . GLN B 1 200 ? -4.303  -35.027 17.904 1.00 20.16  ? 223 GLN B OE1 1 ? 
ATOM   4019 N NE2 . GLN B 1 200 ? -4.836  -37.202 18.010 1.00 20.36  ? 223 GLN B NE2 1 ? 
ATOM   4020 N N   . LYS B 1 201 ? -0.687  -39.656 17.238 1.00 26.74  ? 224 LYS B N   1 ? 
ATOM   4021 C CA  . LYS B 1 201 ? 0.516   -40.310 16.668 1.00 33.48  ? 224 LYS B CA  1 ? 
ATOM   4022 C C   . LYS B 1 201 ? 1.310   -39.318 15.818 1.00 28.28  ? 224 LYS B C   1 ? 
ATOM   4023 O O   . LYS B 1 201 ? 2.516   -39.489 15.685 1.00 32.11  ? 224 LYS B O   1 ? 
ATOM   4024 C CB  . LYS B 1 201 ? 0.096   -41.539 15.856 1.00 34.34  ? 224 LYS B CB  1 ? 
ATOM   4025 C CG  . LYS B 1 201 ? 1.243   -42.322 15.238 1.00 48.87  ? 224 LYS B CG  1 ? 
ATOM   4026 C CD  . LYS B 1 201 ? 1.453   -43.704 15.839 1.00 63.08  ? 224 LYS B CD  1 ? 
ATOM   4027 C CE  . LYS B 1 201 ? 1.759   -44.717 14.787 1.00 63.22  ? 224 LYS B CE  1 ? 
ATOM   4028 N NZ  . LYS B 1 201 ? 2.762   -44.224 13.842 1.00 55.97  ? 224 LYS B NZ  1 ? 
ATOM   4029 N N   . TYR B 1 202 ? 0.642   -38.301 15.295 1.00 31.25  ? 225 TYR B N   1 ? 
ATOM   4030 C CA  . TYR B 1 202 ? 1.365   -37.396 14.374 1.00 25.72  ? 225 TYR B CA  1 ? 
ATOM   4031 C C   . TYR B 1 202 ? 1.268   -35.968 14.823 1.00 25.90  ? 225 TYR B C   1 ? 
ATOM   4032 O O   . TYR B 1 202 ? 0.154   -35.462 14.975 1.00 26.74  ? 225 TYR B O   1 ? 
ATOM   4033 C CB  . TYR B 1 202 ? 0.839   -37.565 12.950 1.00 26.51  ? 225 TYR B CB  1 ? 
ATOM   4034 C CG  . TYR B 1 202 ? 0.981   -38.987 12.434 1.00 31.62  ? 225 TYR B CG  1 ? 
ATOM   4035 C CD1 . TYR B 1 202 ? 2.180   -39.441 11.903 1.00 31.81  ? 225 TYR B CD1 1 ? 
ATOM   4036 C CD2 . TYR B 1 202 ? -0.076  -39.880 12.510 1.00 32.30  ? 225 TYR B CD2 1 ? 
ATOM   4037 C CE1 . TYR B 1 202 ? 2.312   -40.740 11.445 1.00 34.85  ? 225 TYR B CE1 1 ? 
ATOM   4038 C CE2 . TYR B 1 202 ? 0.040   -41.177 12.048 1.00 35.57  ? 225 TYR B CE2 1 ? 
ATOM   4039 C CZ  . TYR B 1 202 ? 1.239   -41.609 11.515 1.00 35.70  ? 225 TYR B CZ  1 ? 
ATOM   4040 O OH  . TYR B 1 202 ? 1.348   -42.891 11.066 1.00 37.67  ? 225 TYR B OH  1 ? 
ATOM   4041 N N   . PHE B 1 203 ? 2.430   -35.340 14.982 1.00 23.65  ? 226 PHE B N   1 ? 
ATOM   4042 C CA  . PHE B 1 203 ? 2.487   -33.904 15.314 1.00 26.53  ? 226 PHE B CA  1 ? 
ATOM   4043 C C   . PHE B 1 203 ? 3.141   -33.190 14.142 1.00 30.15  ? 226 PHE B C   1 ? 
ATOM   4044 O O   . PHE B 1 203 ? 4.021   -33.768 13.506 1.00 33.88  ? 226 PHE B O   1 ? 
ATOM   4045 C CB  . PHE B 1 203 ? 3.311   -33.655 16.575 1.00 21.55  ? 226 PHE B CB  1 ? 
ATOM   4046 C CG  . PHE B 1 203 ? 2.667   -34.082 17.879 1.00 23.25  ? 226 PHE B CG  1 ? 
ATOM   4047 C CD1 . PHE B 1 203 ? 2.726   -35.401 18.301 1.00 21.25  ? 226 PHE B CD1 1 ? 
ATOM   4048 C CD2 . PHE B 1 203 ? 2.013   -33.158 18.680 1.00 21.72  ? 226 PHE B CD2 1 ? 
ATOM   4049 C CE1 . PHE B 1 203 ? 2.141   -35.783 19.490 1.00 21.16  ? 226 PHE B CE1 1 ? 
ATOM   4050 C CE2 . PHE B 1 203 ? 1.432   -33.553 19.868 1.00 22.20  ? 226 PHE B CE2 1 ? 
ATOM   4051 C CZ  . PHE B 1 203 ? 1.495   -34.860 20.269 1.00 23.67  ? 226 PHE B CZ  1 ? 
ATOM   4052 N N   . THR B 1 204 ? 2.704   -31.973 13.861 1.00 22.22  ? 227 THR B N   1 ? 
ATOM   4053 C CA  . THR B 1 204 ? 3.340   -31.169 12.817 1.00 24.94  ? 227 THR B CA  1 ? 
ATOM   4054 C C   . THR B 1 204 ? 3.769   -29.859 13.441 1.00 32.59  ? 227 THR B C   1 ? 
ATOM   4055 O O   . THR B 1 204 ? 2.896   -29.166 13.996 1.00 32.35  ? 227 THR B O   1 ? 
ATOM   4056 C CB  . THR B 1 204 ? 2.398   -30.973 11.633 1.00 24.79  ? 227 THR B CB  1 ? 
ATOM   4057 O OG1 . THR B 1 204 ? 2.383   -32.209 10.930 1.00 30.22  ? 227 THR B OG1 1 ? 
ATOM   4058 C CG2 . THR B 1 204 ? 2.846   -29.849 10.719 1.00 21.75  ? 227 THR B CG2 1 ? 
ATOM   4059 N N   . GLU B 1 205 ? 5.065   -29.545 13.382 1.00 32.48  ? 228 GLU B N   1 ? 
ATOM   4060 C CA  . GLU B 1 205 ? 5.577   -28.256 13.914 1.00 26.24  ? 228 GLU B CA  1 ? 
ATOM   4061 C C   . GLU B 1 205 ? 5.189   -27.170 12.916 1.00 23.60  ? 228 GLU B C   1 ? 
ATOM   4062 O O   . GLU B 1 205 ? 5.954   -26.947 11.970 1.00 25.51  ? 228 GLU B O   1 ? 
ATOM   4063 C CB  . GLU B 1 205 ? 7.075   -28.243 14.208 1.00 27.86  ? 228 GLU B CB  1 ? 
ATOM   4064 C CG  . GLU B 1 205 ? 7.508   -26.988 14.956 1.00 28.03  ? 228 GLU B CG  1 ? 
ATOM   4065 C CD  . GLU B 1 205 ? 8.899   -27.033 15.555 1.00 32.23  ? 228 GLU B CD  1 ? 
ATOM   4066 O OE1 . GLU B 1 205 ? 9.440   -25.947 15.825 1.00 39.38  ? 228 GLU B OE1 1 ? 
ATOM   4067 O OE2 . GLU B 1 205 ? 9.439   -28.135 15.753 1.00 36.69  ? 228 GLU B OE2 1 ? 
ATOM   4068 N N   . SER B 1 206 ? 4.085   -26.487 13.177 1.00 25.67  ? 229 SER B N   1 ? 
ATOM   4069 C CA  . SER B 1 206 ? 3.521   -25.489 12.234 1.00 27.73  ? 229 SER B CA  1 ? 
ATOM   4070 C C   . SER B 1 206 ? 3.765   -24.057 12.709 1.00 25.66  ? 229 SER B C   1 ? 
ATOM   4071 O O   . SER B 1 206 ? 3.799   -23.160 11.858 1.00 24.49  ? 229 SER B O   1 ? 
ATOM   4072 C CB  . SER B 1 206 ? 2.038   -25.740 12.123 1.00 24.26  ? 229 SER B CB  1 ? 
ATOM   4073 O OG  . SER B 1 206 ? 1.483   -26.061 13.388 1.00 22.63  ? 229 SER B OG  1 ? 
ATOM   4074 N N   . ASN B 1 207 ? 3.867   -23.853 14.020 1.00 25.03  ? 230 ASN B N   1 ? 
ATOM   4075 C CA  . ASN B 1 207 ? 4.005   -22.478 14.576 1.00 24.44  ? 230 ASN B CA  1 ? 
ATOM   4076 C C   . ASN B 1 207 ? 2.925   -21.600 13.937 1.00 22.24  ? 230 ASN B C   1 ? 
ATOM   4077 O O   . ASN B 1 207 ? 3.231   -20.464 13.600 1.00 23.53  ? 230 ASN B O   1 ? 
ATOM   4078 C CB  . ASN B 1 207 ? 5.447   -21.990 14.477 1.00 23.95  ? 230 ASN B CB  1 ? 
ATOM   4079 C CG  . ASN B 1 207 ? 6.365   -22.894 15.258 1.00 22.44  ? 230 ASN B CG  1 ? 
ATOM   4080 O OD1 . ASN B 1 207 ? 6.132   -23.129 16.444 1.00 18.18  ? 230 ASN B OD1 1 ? 
ATOM   4081 N ND2 . ASN B 1 207 ? 7.383   -23.432 14.608 1.00 22.63  ? 230 ASN B ND2 1 ? 
ATOM   4082 N N   . HIS B 1 208 ? 1.696   -22.116 13.854 1.00 20.15  ? 231 HIS B N   1 ? 
ATOM   4083 C CA  . HIS B 1 208 ? 0.609   -21.421 13.115 1.00 20.98  ? 231 HIS B CA  1 ? 
ATOM   4084 C C   . HIS B 1 208 ? -0.182  -20.452 13.999 1.00 24.55  ? 231 HIS B C   1 ? 
ATOM   4085 O O   . HIS B 1 208 ? -1.062  -19.750 13.494 1.00 23.32  ? 231 HIS B O   1 ? 
ATOM   4086 C CB  . HIS B 1 208 ? -0.333  -22.466 12.511 1.00 25.20  ? 231 HIS B CB  1 ? 
ATOM   4087 C CG  . HIS B 1 208 ? -1.078  -23.267 13.519 1.00 19.37  ? 231 HIS B CG  1 ? 
ATOM   4088 N ND1 . HIS B 1 208 ? -0.558  -24.396 14.106 1.00 21.46  ? 231 HIS B ND1 1 ? 
ATOM   4089 C CD2 . HIS B 1 208 ? -2.294  -23.103 14.044 1.00 21.27  ? 231 HIS B CD2 1 ? 
ATOM   4090 C CE1 . HIS B 1 208 ? -1.443  -24.887 14.956 1.00 17.73  ? 231 HIS B CE1 1 ? 
ATOM   4091 N NE2 . HIS B 1 208 ? -2.502  -24.118 14.931 1.00 16.71  ? 231 HIS B NE2 1 ? 
ATOM   4092 N N   . GLY B 1 209 ? 0.120   -20.451 15.292 1.00 23.82  ? 232 GLY B N   1 ? 
ATOM   4093 C CA  . GLY B 1 209 ? -0.583  -19.581 16.233 1.00 21.49  ? 232 GLY B CA  1 ? 
ATOM   4094 C C   . GLY B 1 209 ? 0.069   -19.650 17.587 1.00 21.93  ? 232 GLY B C   1 ? 
ATOM   4095 O O   . GLY B 1 209 ? 1.191   -20.146 17.675 1.00 25.69  ? 232 GLY B O   1 ? 
ATOM   4096 N N   . LEU B 1 210 ? -0.628  -19.173 18.605 1.00 20.43  ? 233 LEU B N   1 ? 
ATOM   4097 C CA  . LEU B 1 210 ? 0.012   -19.113 19.932 1.00 24.07  ? 233 LEU B CA  1 ? 
ATOM   4098 C C   . LEU B 1 210 ? -0.965  -19.399 21.064 1.00 22.15  ? 233 LEU B C   1 ? 
ATOM   4099 O O   . LEU B 1 210 ? -2.164  -19.243 20.861 1.00 18.10  ? 233 LEU B O   1 ? 
ATOM   4100 C CB  . LEU B 1 210 ? 0.604   -17.726 20.171 1.00 27.72  ? 233 LEU B CB  1 ? 
ATOM   4101 C CG  . LEU B 1 210 ? -0.376  -16.557 20.075 1.00 29.91  ? 233 LEU B CG  1 ? 
ATOM   4102 C CD1 . LEU B 1 210 ? -0.515  -15.820 21.387 1.00 36.44  ? 233 LEU B CD1 1 ? 
ATOM   4103 C CD2 . LEU B 1 210 ? 0.096   -15.617 18.996 1.00 47.93  ? 233 LEU B CD2 1 ? 
ATOM   4104 N N   . VAL B 1 211 ? -0.416  -19.853 22.186 1.00 20.45  ? 234 VAL B N   1 ? 
ATOM   4105 C CA  . VAL B 1 211 ? -1.207  -19.927 23.439 1.00 20.10  ? 234 VAL B CA  1 ? 
ATOM   4106 C C   . VAL B 1 211 ? -0.460  -18.981 24.399 1.00 23.17  ? 234 VAL B C   1 ? 
ATOM   4107 O O   . VAL B 1 211 ? 0.678   -19.289 24.747 1.00 19.09  ? 234 VAL B O   1 ? 
ATOM   4108 C CB  . VAL B 1 211 ? -1.452  -21.297 24.100 1.00 18.14  ? 234 VAL B CB  1 ? 
ATOM   4109 C CG1 . VAL B 1 211 ? -2.199  -21.159 25.418 1.00 18.61  ? 234 VAL B CG1 1 ? 
ATOM   4110 C CG2 . VAL B 1 211 ? -2.186  -22.254 23.174 1.00 21.53  ? 234 VAL B CG2 1 ? 
ATOM   4111 N N   . ASP B 1 212 ? -1.037  -17.820 24.670 1.00 18.63  ? 235 ASP B N   1 ? 
ATOM   4112 C CA  . ASP B 1 212 ? -0.499  -16.890 25.684 1.00 22.55  ? 235 ASP B CA  1 ? 
ATOM   4113 C C   . ASP B 1 212 ? -1.650  -16.593 26.653 1.00 21.28  ? 235 ASP B C   1 ? 
ATOM   4114 O O   . ASP B 1 212 ? -2.791  -16.953 26.338 1.00 19.93  ? 235 ASP B O   1 ? 
ATOM   4115 C CB  . ASP B 1 212 ? 0.098   -15.650 25.046 1.00 20.95  ? 235 ASP B CB  1 ? 
ATOM   4116 C CG  . ASP B 1 212 ? 1.610   -15.643 24.898 1.00 24.50  ? 235 ASP B CG  1 ? 
ATOM   4117 O OD1 . ASP B 1 212 ? 2.196   -16.737 24.789 1.00 24.67  ? 235 ASP B OD1 1 ? 
ATOM   4118 O OD2 . ASP B 1 212 ? 2.182   -14.542 24.898 1.00 27.86  ? 235 ASP B OD2 1 ? 
ATOM   4119 N N   . TYR B 1 213 ? -1.354  -15.921 27.758 1.00 17.24  ? 236 TYR B N   1 ? 
ATOM   4120 C CA  . TYR B 1 213 ? -2.373  -15.703 28.801 1.00 15.61  ? 236 TYR B CA  1 ? 
ATOM   4121 C C   . TYR B 1 213 ? -2.446  -14.275 29.259 1.00 15.97  ? 236 TYR B C   1 ? 
ATOM   4122 O O   . TYR B 1 213 ? -1.458  -13.552 29.183 1.00 15.95  ? 236 TYR B O   1 ? 
ATOM   4123 C CB  . TYR B 1 213 ? -1.964  -16.470 30.057 1.00 13.72  ? 236 TYR B CB  1 ? 
ATOM   4124 C CG  . TYR B 1 213 ? -1.649  -17.939 29.826 1.00 12.59  ? 236 TYR B CG  1 ? 
ATOM   4125 C CD1 . TYR B 1 213 ? -2.595  -18.793 29.279 1.00 14.86  ? 236 TYR B CD1 1 ? 
ATOM   4126 C CD2 . TYR B 1 213 ? -0.408  -18.466 30.151 1.00 16.12  ? 236 TYR B CD2 1 ? 
ATOM   4127 C CE1 . TYR B 1 213 ? -2.318  -20.130 29.062 1.00 15.70  ? 236 TYR B CE1 1 ? 
ATOM   4128 C CE2 . TYR B 1 213 ? -0.118  -19.802 29.938 1.00 16.86  ? 236 TYR B CE2 1 ? 
ATOM   4129 C CZ  . TYR B 1 213 ? -1.077  -20.638 29.396 1.00 16.30  ? 236 TYR B CZ  1 ? 
ATOM   4130 O OH  . TYR B 1 213 ? -0.804  -21.956 29.192 1.00 14.86  ? 236 TYR B OH  1 ? 
ATOM   4131 N N   . MET B 1 214 ? -3.647  -13.887 29.660 1.00 14.95  ? 237 MET B N   1 ? 
ATOM   4132 C CA  . MET B 1 214 ? -3.782  -12.593 30.342 1.00 12.97  ? 237 MET B CA  1 ? 
ATOM   4133 C C   . MET B 1 214 ? -4.053  -12.930 31.815 1.00 14.20  ? 237 MET B C   1 ? 
ATOM   4134 O O   . MET B 1 214 ? -5.031  -13.617 32.080 1.00 14.80  ? 237 MET B O   1 ? 
ATOM   4135 C CB  . MET B 1 214 ? -4.915  -11.704 29.831 1.00 12.58  ? 237 MET B CB  1 ? 
ATOM   4136 C CG  . MET B 1 214 ? -4.865  -10.319 30.417 1.00 13.24  ? 237 MET B CG  1 ? 
ATOM   4137 S SD  . MET B 1 214 ? -6.219  -9.270  29.858 1.00 17.22  ? 237 MET B SD  1 ? 
ATOM   4138 C CE  . MET B 1 214 ? -5.857  -9.198  28.098 1.00 14.13  ? 237 MET B CE  1 ? 
ATOM   4139 N N   . VAL B 1 215 ? -3.141  -12.536 32.689 1.00 13.80  ? 238 VAL B N   1 ? 
ATOM   4140 C CA  . VAL B 1 215 ? -3.393  -12.688 34.145 1.00 14.16  ? 238 VAL B CA  1 ? 
ATOM   4141 C C   . VAL B 1 215 ? -4.479  -11.659 34.459 1.00 15.69  ? 238 VAL B C   1 ? 
ATOM   4142 O O   . VAL B 1 215 ? -4.292  -10.496 34.114 1.00 14.29  ? 238 VAL B O   1 ? 
ATOM   4143 C CB  . VAL B 1 215 ? -2.165  -12.489 35.054 1.00 14.63  ? 238 VAL B CB  1 ? 
ATOM   4144 C CG1 . VAL B 1 215 ? -2.525  -12.606 36.527 1.00 15.58  ? 238 VAL B CG1 1 ? 
ATOM   4145 C CG2 . VAL B 1 215 ? -1.045  -13.448 34.687 1.00 14.88  ? 238 VAL B CG2 1 ? 
ATOM   4146 N N   . ILE B 1 216 ? -5.548  -12.115 35.099 1.00 15.97  ? 239 ILE B N   1 ? 
ATOM   4147 C CA  . ILE B 1 216 ? -6.692  -11.215 35.390 1.00 13.53  ? 239 ILE B CA  1 ? 
ATOM   4148 C C   . ILE B 1 216 ? -7.181  -11.367 36.836 1.00 15.88  ? 239 ILE B C   1 ? 
ATOM   4149 O O   . ILE B 1 216 ? -6.936  -12.414 37.455 1.00 13.44  ? 239 ILE B O   1 ? 
ATOM   4150 C CB  . ILE B 1 216 ? -7.847  -11.476 34.404 1.00 12.99  ? 239 ILE B CB  1 ? 
ATOM   4151 C CG1 . ILE B 1 216 ? -8.337  -12.911 34.489 1.00 11.76  ? 239 ILE B CG1 1 ? 
ATOM   4152 C CG2 . ILE B 1 216 ? -7.464  -11.101 32.976 1.00 12.46  ? 239 ILE B CG2 1 ? 
ATOM   4153 C CD1 . ILE B 1 216 ? -9.518  -13.201 33.587 1.00 10.97  ? 239 ILE B CD1 1 ? 
ATOM   4154 N N   . THR B 1 217 ? -7.846  -10.320 37.313 1.00 15.66  ? 240 THR B N   1 ? 
ATOM   4155 C CA  . THR B 1 217 ? -8.479  -10.366 38.629 1.00 15.38  ? 240 THR B CA  1 ? 
ATOM   4156 C C   . THR B 1 217 ? -9.831  -9.699  38.532 1.00 18.13  ? 240 THR B C   1 ? 
ATOM   4157 O O   . THR B 1 217 ? -10.154 -9.160  37.456 1.00 13.18  ? 240 THR B O   1 ? 
ATOM   4158 C CB  . THR B 1 217 ? -7.627  -9.660  39.687 1.00 16.01  ? 240 THR B CB  1 ? 
ATOM   4159 O OG1 . THR B 1 217 ? -8.303  -9.792  40.931 1.00 16.00  ? 240 THR B OG1 1 ? 
ATOM   4160 C CG2 . THR B 1 217 ? -7.390  -8.204  39.331 1.00 13.62  ? 240 THR B CG2 1 ? 
ATOM   4161 N N   . ASN B 1 218 ? -10.600 -9.800  39.603 1.00 14.65  ? 241 ASN B N   1 ? 
ATOM   4162 C CA  . ASN B 1 218 ? -11.874 -9.061  39.698 1.00 17.57  ? 241 ASN B CA  1 ? 
ATOM   4163 C C   . ASN B 1 218 ? -11.501 -7.597  39.982 1.00 15.04  ? 241 ASN B C   1 ? 
ATOM   4164 O O   . ASN B 1 218 ? -10.929 -7.330  41.021 1.00 14.65  ? 241 ASN B O   1 ? 
ATOM   4165 C CB  . ASN B 1 218 ? -12.768 -9.732  40.734 1.00 18.58  ? 241 ASN B CB  1 ? 
ATOM   4166 C CG  . ASN B 1 218 ? -14.085 -9.031  40.947 1.00 21.50  ? 241 ASN B CG  1 ? 
ATOM   4167 O OD1 . ASN B 1 218 ? -14.115 -7.855  41.317 1.00 19.89  ? 241 ASN B OD1 1 ? 
ATOM   4168 N ND2 . ASN B 1 218 ? -15.179 -9.749  40.747 1.00 17.80  ? 241 ASN B ND2 1 ? 
ATOM   4169 N N   . ALA B 1 219 ? -11.852 -6.695  39.074 1.00 17.86  ? 242 ALA B N   1 ? 
ATOM   4170 C CA  . ALA B 1 219 ? -11.428 -5.279  39.218 1.00 19.55  ? 242 ALA B CA  1 ? 
ATOM   4171 C C   . ALA B 1 219 ? -11.881 -4.702  40.558 1.00 19.89  ? 242 ALA B C   1 ? 
ATOM   4172 O O   . ALA B 1 219 ? -11.111 -4.004  41.191 1.00 18.71  ? 242 ALA B O   1 ? 
ATOM   4173 C CB  . ALA B 1 219 ? -11.941 -4.458  38.076 1.00 18.93  ? 242 ALA B CB  1 ? 
ATOM   4174 N N   . LYS B 1 220 ? -13.110 -5.019  40.948 1.00 21.68  ? 243 LYS B N   1 ? 
ATOM   4175 C CA  . LYS B 1 220 ? -13.647 -4.471  42.218 1.00 22.50  ? 243 LYS B CA  1 ? 
ATOM   4176 C C   . LYS B 1 220 ? -12.823 -5.019  43.394 1.00 19.03  ? 243 LYS B C   1 ? 
ATOM   4177 O O   . LYS B 1 220 ? -12.479 -4.245  44.278 1.00 19.37  ? 243 LYS B O   1 ? 
ATOM   4178 C CB  . LYS B 1 220 ? -15.144 -4.761  42.343 1.00 23.15  ? 243 LYS B CB  1 ? 
ATOM   4179 C CG  . LYS B 1 220 ? -15.849 -4.137  43.523 1.00 26.48  ? 243 LYS B CG  1 ? 
ATOM   4180 C CD  . LYS B 1 220 ? -17.362 -4.269  43.426 1.00 36.70  ? 243 LYS B CD  1 ? 
ATOM   4181 C CE  . LYS B 1 220 ? -18.014 -3.870  44.702 1.00 46.34  ? 243 LYS B CE  1 ? 
ATOM   4182 N NZ  . LYS B 1 220 ? -17.878 -4.922  45.707 1.00 50.73  ? 243 LYS B NZ  1 ? 
ATOM   4183 N N   . PHE B 1 221 ? -12.537 -6.318  43.376 1.00 21.08  ? 244 PHE B N   1 ? 
ATOM   4184 C CA  . PHE B 1 221 ? -11.746 -6.947  44.466 1.00 18.48  ? 244 PHE B CA  1 ? 
ATOM   4185 C C   . PHE B 1 221 ? -10.386 -6.262  44.535 1.00 15.79  ? 244 PHE B C   1 ? 
ATOM   4186 O O   . PHE B 1 221 ? -9.913  -5.926  45.619 1.00 18.07  ? 244 PHE B O   1 ? 
ATOM   4187 C CB  . PHE B 1 221 ? -11.567 -8.443  44.198 1.00 17.36  ? 244 PHE B CB  1 ? 
ATOM   4188 C CG  . PHE B 1 221 ? -10.430 -9.070  44.993 1.00 18.44  ? 244 PHE B CG  1 ? 
ATOM   4189 C CD1 . PHE B 1 221 ? -10.594 -9.392  46.333 1.00 15.95  ? 244 PHE B CD1 1 ? 
ATOM   4190 C CD2 . PHE B 1 221 ? -9.195  -9.317  44.408 1.00 19.08  ? 244 PHE B CD2 1 ? 
ATOM   4191 C CE1 . PHE B 1 221 ? -9.559  -9.956  47.057 1.00 17.13  ? 244 PHE B CE1 1 ? 
ATOM   4192 C CE2 . PHE B 1 221 ? -8.164  -9.875  45.139 1.00 16.71  ? 244 PHE B CE2 1 ? 
ATOM   4193 C CZ  . PHE B 1 221 ? -8.350  -10.198 46.459 1.00 15.43  ? 244 PHE B CZ  1 ? 
ATOM   4194 N N   . TRP B 1 222 ? -9.783  -6.059  43.371 1.00 15.99  ? 245 TRP B N   1 ? 
ATOM   4195 C CA  . TRP B 1 222 ? -8.426  -5.468  43.289 1.00 15.84  ? 245 TRP B CA  1 ? 
ATOM   4196 C C   . TRP B 1 222 ? -8.437  -4.000  43.738 1.00 16.39  ? 245 TRP B C   1 ? 
ATOM   4197 O O   . TRP B 1 222 ? -7.548  -3.589  44.479 1.00 16.24  ? 245 TRP B O   1 ? 
ATOM   4198 C CB  . TRP B 1 222 ? -7.930  -5.605  41.851 1.00 14.92  ? 245 TRP B CB  1 ? 
ATOM   4199 C CG  . TRP B 1 222 ? -6.441  -5.489  41.680 1.00 18.56  ? 245 TRP B CG  1 ? 
ATOM   4200 C CD1 . TRP B 1 222 ? -5.756  -4.432  41.161 1.00 15.85  ? 245 TRP B CD1 1 ? 
ATOM   4201 C CD2 . TRP B 1 222 ? -5.452  -6.486  42.010 1.00 14.87  ? 245 TRP B CD2 1 ? 
ATOM   4202 N NE1 . TRP B 1 222 ? -4.414  -4.695  41.151 1.00 18.94  ? 245 TRP B NE1 1 ? 
ATOM   4203 C CE2 . TRP B 1 222 ? -4.196  -5.943  41.666 1.00 14.85  ? 245 TRP B CE2 1 ? 
ATOM   4204 C CE3 . TRP B 1 222 ? -5.504  -7.769  42.559 1.00 14.85  ? 245 TRP B CE3 1 ? 
ATOM   4205 C CZ2 . TRP B 1 222 ? -3.009  -6.642  41.856 1.00 14.84  ? 245 TRP B CZ2 1 ? 
ATOM   4206 C CZ3 . TRP B 1 222 ? -4.329  -8.460  42.742 1.00 15.73  ? 245 TRP B CZ3 1 ? 
ATOM   4207 C CH2 . TRP B 1 222 ? -3.102  -7.903  42.395 1.00 14.32  ? 245 TRP B CH2 1 ? 
ATOM   4208 N N   . ASN B 1 223 ? -9.444  -3.254  43.298 1.00 16.66  ? 246 ASN B N   1 ? 
ATOM   4209 C CA  . ASN B 1 223 ? -9.521  -1.817  43.651 1.00 18.04  ? 246 ASN B CA  1 ? 
ATOM   4210 C C   . ASN B 1 223 ? -9.807  -1.667  45.147 1.00 22.37  ? 246 ASN B C   1 ? 
ATOM   4211 O O   . ASN B 1 223 ? -9.375  -0.679  45.718 1.00 23.24  ? 246 ASN B O   1 ? 
ATOM   4212 C CB  . ASN B 1 223 ? -10.529 -1.097  42.770 1.00 21.23  ? 246 ASN B CB  1 ? 
ATOM   4213 C CG  . ASN B 1 223 ? -10.064 -1.007  41.342 1.00 23.13  ? 246 ASN B CG  1 ? 
ATOM   4214 O OD1 . ASN B 1 223 ? -8.866  -0.868  41.091 1.00 24.07  ? 246 ASN B OD1 1 ? 
ATOM   4215 N ND2 . ASN B 1 223 ? -10.993 -1.079  40.403 1.00 31.79  ? 246 ASN B ND2 1 ? 
ATOM   4216 N N   . GLY B 1 224 ? -10.507 -2.629  45.732 1.00 19.53  ? 247 GLY B N   1 ? 
ATOM   4217 C CA  . GLY B 1 224 ? -10.878 -2.568  47.156 1.00 21.95  ? 247 GLY B CA  1 ? 
ATOM   4218 C C   . GLY B 1 224 ? -9.758  -3.005  48.071 1.00 20.25  ? 247 GLY B C   1 ? 
ATOM   4219 O O   . GLY B 1 224 ? -9.918  -2.912  49.284 1.00 21.19  ? 247 GLY B O   1 ? 
ATOM   4220 N N   . LEU B 1 225 ? -8.651  -3.445  47.485 1.00 19.01  ? 248 LEU B N   1 ? 
ATOM   4221 C CA  . LEU B 1 225 ? -7.485  -3.832  48.303 1.00 22.62  ? 248 LEU B CA  1 ? 
ATOM   4222 C C   . LEU B 1 225 ? -6.900  -2.574  48.934 1.00 18.45  ? 248 LEU B C   1 ? 
ATOM   4223 O O   . LEU B 1 225 ? -7.062  -1.487  48.352 1.00 17.80  ? 248 LEU B O   1 ? 
ATOM   4224 C CB  . LEU B 1 225 ? -6.429  -4.540  47.456 1.00 17.62  ? 248 LEU B CB  1 ? 
ATOM   4225 C CG  . LEU B 1 225 ? -6.724  -5.970  46.997 1.00 19.20  ? 248 LEU B CG  1 ? 
ATOM   4226 C CD1 . LEU B 1 225 ? -5.708  -6.362  45.946 1.00 15.43  ? 248 LEU B CD1 1 ? 
ATOM   4227 C CD2 . LEU B 1 225 ? -6.681  -6.938  48.152 1.00 18.12  ? 248 LEU B CD2 1 ? 
ATOM   4228 N N   . PRO B 1 226 ? -6.247  -2.672  50.108 1.00 21.76  ? 249 PRO B N   1 ? 
ATOM   4229 C CA  . PRO B 1 226 ? -5.531  -1.524  50.642 1.00 20.23  ? 249 PRO B CA  1 ? 
ATOM   4230 C C   . PRO B 1 226 ? -4.458  -1.193  49.596 1.00 18.18  ? 249 PRO B C   1 ? 
ATOM   4231 O O   . PRO B 1 226 ? -3.860  -2.113  49.037 1.00 17.94  ? 249 PRO B O   1 ? 
ATOM   4232 C CB  . PRO B 1 226 ? -4.983  -2.036  51.968 1.00 20.15  ? 249 PRO B CB  1 ? 
ATOM   4233 C CG  . PRO B 1 226 ? -5.873  -3.204  52.303 1.00 22.87  ? 249 PRO B CG  1 ? 
ATOM   4234 C CD  . PRO B 1 226 ? -6.208  -3.835  50.965 1.00 24.08  ? 249 PRO B CD  1 ? 
ATOM   4235 N N   . ALA B 1 227 ? -4.237  0.090   49.323 1.00 17.90  ? 250 ALA B N   1 ? 
ATOM   4236 C CA  . ALA B 1 227 ? -3.314  0.516   48.240 1.00 16.98  ? 250 ALA B CA  1 ? 
ATOM   4237 C C   . ALA B 1 227 ? -1.922  -0.116  48.358 1.00 19.29  ? 250 ALA B C   1 ? 
ATOM   4238 O O   . ALA B 1 227 ? -1.374  -0.554  47.345 1.00 20.92  ? 250 ALA B O   1 ? 
ATOM   4239 C CB  . ALA B 1 227 ? -3.233  2.023   48.210 1.00 19.06  ? 250 ALA B CB  1 ? 
ATOM   4240 N N   . ASP B 1 228 ? -1.360  -0.139  49.559 1.00 15.51  ? 251 ASP B N   1 ? 
ATOM   4241 C CA  . ASP B 1 228 ? 0.017   -0.666  49.720 1.00 21.39  ? 251 ASP B CA  1 ? 
ATOM   4242 C C   . ASP B 1 228 ? 0.034   -2.135  49.291 1.00 21.20  ? 251 ASP B C   1 ? 
ATOM   4243 O O   . ASP B 1 228 ? 0.955   -2.535  48.582 1.00 24.45  ? 251 ASP B O   1 ? 
ATOM   4244 C CB  . ASP B 1 228 ? 0.523   -0.444  51.134 1.00 21.22  ? 251 ASP B CB  1 ? 
ATOM   4245 C CG  . ASP B 1 228 ? -0.250  -1.159  52.226 1.00 27.06  ? 251 ASP B CG  1 ? 
ATOM   4246 O OD1 . ASP B 1 228 ? -1.487  -1.058  52.216 1.00 27.90  ? 251 ASP B OD1 1 ? 
ATOM   4247 O OD2 . ASP B 1 228 ? 0.399   -1.812  53.062 1.00 35.41  ? 251 ASP B OD2 1 ? 
ATOM   4248 N N   . ILE B 1 229 ? -0.986  -2.876  49.697 1.00 17.04  ? 252 ILE B N   1 ? 
ATOM   4249 C CA  . ILE B 1 229 ? -1.077  -4.317  49.344 1.00 16.96  ? 252 ILE B CA  1 ? 
ATOM   4250 C C   . ILE B 1 229 ? -1.207  -4.466  47.820 1.00 17.09  ? 252 ILE B C   1 ? 
ATOM   4251 O O   . ILE B 1 229 ? -0.421  -5.213  47.247 1.00 17.89  ? 252 ILE B O   1 ? 
ATOM   4252 C CB  . ILE B 1 229 ? -2.211  -4.989  50.136 1.00 19.97  ? 252 ILE B CB  1 ? 
ATOM   4253 C CG1 . ILE B 1 229 ? -1.839  -5.057  51.613 1.00 21.48  ? 252 ILE B CG1 1 ? 
ATOM   4254 C CG2 . ILE B 1 229 ? -2.542  -6.363  49.566 1.00 21.58  ? 252 ILE B CG2 1 ? 
ATOM   4255 C CD1 . ILE B 1 229 ? -2.781  -5.880  52.466 1.00 19.99  ? 252 ILE B CD1 1 ? 
ATOM   4256 N N   . ARG B 1 230 ? -2.135  -3.733  47.208 1.00 15.23  ? 253 ARG B N   1 ? 
ATOM   4257 C CA  . ARG B 1 230 ? -2.312  -3.798  45.733 1.00 15.93  ? 253 ARG B CA  1 ? 
ATOM   4258 C C   . ARG B 1 230 ? -0.980  -3.513  45.011 1.00 18.91  ? 253 ARG B C   1 ? 
ATOM   4259 O O   . ARG B 1 230 ? -0.615  -4.271  44.102 1.00 16.46  ? 253 ARG B O   1 ? 
ATOM   4260 C CB  . ARG B 1 230 ? -3.368  -2.812  45.226 1.00 15.44  ? 253 ARG B CB  1 ? 
ATOM   4261 C CG  . ARG B 1 230 ? -3.470  -2.696  43.714 1.00 14.78  ? 253 ARG B CG  1 ? 
ATOM   4262 C CD  . ARG B 1 230 ? -4.719  -1.954  43.274 1.00 15.53  ? 253 ARG B CD  1 ? 
ATOM   4263 N NE  . ARG B 1 230 ? -4.777  -0.586  43.794 1.00 18.90  ? 253 ARG B NE  1 ? 
ATOM   4264 C CZ  . ARG B 1 230 ? -5.488  -0.202  44.841 1.00 18.17  ? 253 ARG B CZ  1 ? 
ATOM   4265 N NH1 . ARG B 1 230 ? -6.384  -1.013  45.365 1.00 18.90  ? 253 ARG B NH1 1 ? 
ATOM   4266 N NH2 . ARG B 1 230 ? -5.292  0.988   45.369 1.00 15.68  ? 253 ARG B NH2 1 ? 
ATOM   4267 N N   . GLU B 1 231 ? -0.302  -2.432  45.391 1.00 15.35  ? 254 GLU B N   1 ? 
ATOM   4268 C CA  . GLU B 1 231 ? 0.928   -2.065  44.638 1.00 20.45  ? 254 GLU B CA  1 ? 
ATOM   4269 C C   . GLU B 1 231 ? 1.984   -3.174  44.834 1.00 18.53  ? 254 GLU B C   1 ? 
ATOM   4270 O O   . GLU B 1 231 ? 2.637   -3.555  43.876 1.00 19.86  ? 254 GLU B O   1 ? 
ATOM   4271 C CB  . GLU B 1 231 ? 1.422   -0.666  45.028 1.00 22.68  ? 254 GLU B CB  1 ? 
ATOM   4272 C CG  . GLU B 1 231 ? 0.396   0.434   44.786 1.00 22.69  ? 254 GLU B CG  1 ? 
ATOM   4273 C CD  . GLU B 1 231 ? 0.644   1.694   45.593 1.00 30.85  ? 254 GLU B CD  1 ? 
ATOM   4274 O OE1 . GLU B 1 231 ? -0.190  2.609   45.501 1.00 34.69  ? 254 GLU B OE1 1 ? 
ATOM   4275 O OE2 . GLU B 1 231 ? 1.660   1.761   46.311 1.00 32.63  ? 254 GLU B OE2 1 ? 
ATOM   4276 N N   . GLU B 1 232 ? 2.101   -3.679  46.057 1.00 17.45  ? 255 GLU B N   1 ? 
ATOM   4277 C CA  . GLU B 1 232 ? 3.126   -4.710  46.328 1.00 18.08  ? 255 GLU B CA  1 ? 
ATOM   4278 C C   . GLU B 1 232 ? 2.798   -5.971  45.505 1.00 20.69  ? 255 GLU B C   1 ? 
ATOM   4279 O O   . GLU B 1 232 ? 3.716   -6.526  44.892 1.00 23.10  ? 255 GLU B O   1 ? 
ATOM   4280 C CB  . GLU B 1 232 ? 3.209   -5.001  47.817 1.00 28.03  ? 255 GLU B CB  1 ? 
ATOM   4281 C CG  . GLU B 1 232 ? 3.850   -3.883  48.633 1.00 46.15  ? 255 GLU B CG  1 ? 
ATOM   4282 C CD  . GLU B 1 232 ? 3.817   -4.107  50.134 1.00 47.56  ? 255 GLU B CD  1 ? 
ATOM   4283 O OE1 . GLU B 1 232 ? 4.045   -5.251  50.564 1.00 50.52  ? 255 GLU B OE1 1 ? 
ATOM   4284 O OE2 . GLU B 1 232 ? 3.573   -3.140  50.876 1.00 47.83  ? 255 GLU B OE2 1 ? 
ATOM   4285 N N   . LEU B 1 233 ? 1.533   -6.380  45.501 1.00 16.43  ? 256 LEU B N   1 ? 
ATOM   4286 C CA  . LEU B 1 233 ? 1.109   -7.589  44.750 1.00 17.31  ? 256 LEU B CA  1 ? 
ATOM   4287 C C   . LEU B 1 233 ? 1.444   -7.406  43.257 1.00 16.90  ? 256 LEU B C   1 ? 
ATOM   4288 O O   . LEU B 1 233 ? 1.930   -8.341  42.646 1.00 14.98  ? 256 LEU B O   1 ? 
ATOM   4289 C CB  . LEU B 1 233 ? -0.380  -7.849  44.988 1.00 15.05  ? 256 LEU B CB  1 ? 
ATOM   4290 C CG  . LEU B 1 233 ? -0.791  -8.308  46.388 1.00 16.45  ? 256 LEU B CG  1 ? 
ATOM   4291 C CD1 . LEU B 1 233 ? -2.302  -8.320  46.491 1.00 16.97  ? 256 LEU B CD1 1 ? 
ATOM   4292 C CD2 . LEU B 1 233 ? -0.230  -9.675  46.714 1.00 18.01  ? 256 LEU B CD2 1 ? 
ATOM   4293 N N   . GLN B 1 234 ? 1.211   -6.209  42.734 1.00 15.39  ? 257 GLN B N   1 ? 
ATOM   4294 C CA  . GLN B 1 234 ? 1.463   -5.956  41.296 1.00 19.12  ? 257 GLN B CA  1 ? 
ATOM   4295 C C   . GLN B 1 234 ? 2.967   -6.064  40.991 1.00 17.88  ? 257 GLN B C   1 ? 
ATOM   4296 O O   . GLN B 1 234 ? 3.316   -6.609  39.949 1.00 14.59  ? 257 GLN B O   1 ? 
ATOM   4297 C CB  . GLN B 1 234 ? 0.955   -4.580  40.876 1.00 17.97  ? 257 GLN B CB  1 ? 
ATOM   4298 C CG  . GLN B 1 234 ? 1.211   -4.240  39.415 1.00 18.49  ? 257 GLN B CG  1 ? 
ATOM   4299 C CD  . GLN B 1 234 ? 0.393   -5.095  38.476 1.00 19.58  ? 257 GLN B CD  1 ? 
ATOM   4300 O OE1 . GLN B 1 234 ? -0.838  -5.108  38.539 1.00 20.47  ? 257 GLN B OE1 1 ? 
ATOM   4301 N NE2 . GLN B 1 234 ? 1.073   -5.829  37.610 1.00 15.28  ? 257 GLN B NE2 1 ? 
ATOM   4302 N N   . ARG B 1 235 ? 3.799   -5.537  41.882 1.00 17.56  ? 258 ARG B N   1 ? 
ATOM   4303 C CA  . ARG B 1 235 ? 5.265   -5.595  41.682 1.00 18.35  ? 258 ARG B CA  1 ? 
ATOM   4304 C C   . ARG B 1 235 ? 5.727   -7.061  41.698 1.00 18.35  ? 258 ARG B C   1 ? 
ATOM   4305 O O   . ARG B 1 235 ? 6.580   -7.428  40.901 1.00 19.49  ? 258 ARG B O   1 ? 
ATOM   4306 C CB  . ARG B 1 235 ? 5.989   -4.779  42.753 1.00 22.60  ? 258 ARG B CB  1 ? 
ATOM   4307 C CG  . ARG B 1 235 ? 7.246   -4.082  42.266 1.00 24.19  ? 258 ARG B CG  1 ? 
ATOM   4308 C CD  . ARG B 1 235 ? 7.435   -2.788  43.021 1.00 21.67  ? 258 ARG B CD  1 ? 
ATOM   4309 N NE  . ARG B 1 235 ? 8.787   -2.265  42.816 1.00 25.37  ? 258 ARG B NE  1 ? 
ATOM   4310 C CZ  . ARG B 1 235 ? 9.831   -2.529  43.581 1.00 24.85  ? 258 ARG B CZ  1 ? 
ATOM   4311 N NH1 . ARG B 1 235 ? 11.025  -2.103  43.219 1.00 30.79  ? 258 ARG B NH1 1 ? 
ATOM   4312 N NH2 . ARG B 1 235 ? 9.678   -3.202  44.705 1.00 26.96  ? 258 ARG B NH2 1 ? 
ATOM   4313 N N   . ILE B 1 236 ? 5.163   -7.850  42.600 1.00 18.72  ? 259 ILE B N   1 ? 
ATOM   4314 C CA  . ILE B 1 236 ? 5.551   -9.284  42.679 1.00 16.61  ? 259 ILE B CA  1 ? 
ATOM   4315 C C   . ILE B 1 236 ? 5.067   -9.975  41.392 1.00 18.86  ? 259 ILE B C   1 ? 
ATOM   4316 O O   . ILE B 1 236 ? 5.818   -10.759 40.833 1.00 18.51  ? 259 ILE B O   1 ? 
ATOM   4317 C CB  . ILE B 1 236 ? 4.999   -9.927  43.961 1.00 17.27  ? 259 ILE B CB  1 ? 
ATOM   4318 C CG1 . ILE B 1 236 ? 5.619   -9.325  45.214 1.00 17.11  ? 259 ILE B CG1 1 ? 
ATOM   4319 C CG2 . ILE B 1 236 ? 5.144   -11.448 43.933 1.00 16.92  ? 259 ILE B CG2 1 ? 
ATOM   4320 C CD1 . ILE B 1 236 ? 4.881   -9.688  46.487 1.00 20.30  ? 259 ILE B CD1 1 ? 
ATOM   4321 N N   . MET B 1 237 ? 3.857   -9.656  40.940 1.00 21.34  ? 260 MET B N   1 ? 
ATOM   4322 C CA  . MET B 1 237 ? 3.334   -10.213 39.668 1.00 18.14  ? 260 MET B CA  1 ? 
ATOM   4323 C C   . MET B 1 237 ? 4.301   -9.833  38.537 1.00 18.18  ? 260 MET B C   1 ? 
ATOM   4324 O O   . MET B 1 237 ? 4.567   -10.664 37.672 1.00 16.83  ? 260 MET B O   1 ? 
ATOM   4325 C CB  . MET B 1 237 ? 1.938   -9.665  39.355 1.00 16.31  ? 260 MET B CB  1 ? 
ATOM   4326 C CG  . MET B 1 237 ? 1.353   -10.110 38.029 1.00 16.32  ? 260 MET B CG  1 ? 
ATOM   4327 S SD  . MET B 1 237 ? 1.266   -11.898 37.813 1.00 18.31  ? 260 MET B SD  1 ? 
ATOM   4328 C CE  . MET B 1 237 ? 0.150   -12.400 39.128 1.00 16.01  ? 260 MET B CE  1 ? 
ATOM   4329 N N   . ASP B 1 238 ? 4.763   -8.587  38.542 1.00 18.99  ? 261 ASP B N   1 ? 
ATOM   4330 C CA  . ASP B 1 238 ? 5.748   -8.126  37.526 1.00 19.92  ? 261 ASP B CA  1 ? 
ATOM   4331 C C   . ASP B 1 238 ? 6.995   -9.034  37.536 1.00 19.08  ? 261 ASP B C   1 ? 
ATOM   4332 O O   . ASP B 1 238 ? 7.460   -9.426  36.477 1.00 22.42  ? 261 ASP B O   1 ? 
ATOM   4333 C CB  . ASP B 1 238 ? 6.082   -6.662  37.731 1.00 21.10  ? 261 ASP B CB  1 ? 
ATOM   4334 C CG  . ASP B 1 238 ? 4.932   -5.683  37.550 1.00 24.01  ? 261 ASP B CG  1 ? 
ATOM   4335 O OD1 . ASP B 1 238 ? 3.922   -6.075  36.946 1.00 21.41  ? 261 ASP B OD1 1 ? 
ATOM   4336 O OD2 . ASP B 1 238 ? 5.058   -4.540  38.026 1.00 24.99  ? 261 ASP B OD2 1 ? 
ATOM   4337 N N   . GLU B 1 239 ? 7.496   -9.353  38.717 1.00 15.99  ? 262 GLU B N   1 ? 
ATOM   4338 C CA  . GLU B 1 239 ? 8.698   -10.214 38.793 1.00 22.45  ? 262 GLU B CA  1 ? 
ATOM   4339 C C   . GLU B 1 239 ? 8.341   -11.610 38.278 1.00 21.74  ? 262 GLU B C   1 ? 
ATOM   4340 O O   . GLU B 1 239 ? 9.144   -12.194 37.549 1.00 21.43  ? 262 GLU B O   1 ? 
ATOM   4341 C CB  . GLU B 1 239 ? 9.262   -10.312 40.210 1.00 22.97  ? 262 GLU B CB  1 ? 
ATOM   4342 C CG  . GLU B 1 239 ? 9.809   -8.989  40.727 1.00 37.56  ? 262 GLU B CG  1 ? 
ATOM   4343 C CD  . GLU B 1 239 ? 10.324  -9.157  42.137 1.00 37.50  ? 262 GLU B CD  1 ? 
ATOM   4344 O OE1 . GLU B 1 239 ? 11.123  -10.087 42.355 1.00 31.81  ? 262 GLU B OE1 1 ? 
ATOM   4345 O OE2 . GLU B 1 239 ? 9.914   -8.361  43.002 1.00 47.90  ? 262 GLU B OE2 1 ? 
ATOM   4346 N N   . VAL B 1 240 ? 7.161   -12.099 38.643 1.00 16.79  ? 263 VAL B N   1 ? 
ATOM   4347 C CA  . VAL B 1 240 ? 6.795   -13.496 38.275 1.00 15.35  ? 263 VAL B CA  1 ? 
ATOM   4348 C C   . VAL B 1 240 ? 6.618   -13.572 36.745 1.00 16.59  ? 263 VAL B C   1 ? 
ATOM   4349 O O   . VAL B 1 240 ? 7.041   -14.555 36.158 1.00 17.18  ? 263 VAL B O   1 ? 
ATOM   4350 C CB  . VAL B 1 240 ? 5.569   -13.983 39.072 1.00 13.70  ? 263 VAL B CB  1 ? 
ATOM   4351 C CG1 . VAL B 1 240 ? 5.073   -15.337 38.594 1.00 11.64  ? 263 VAL B CG1 1 ? 
ATOM   4352 C CG2 . VAL B 1 240 ? 5.823   -13.987 40.572 1.00 14.60  ? 263 VAL B CG2 1 ? 
ATOM   4353 N N   . THR B 1 241 ? 6.087   -12.511 36.137 1.00 17.66  ? 264 THR B N   1 ? 
ATOM   4354 C CA  . THR B 1 241 ? 5.901   -12.473 34.669 1.00 19.49  ? 264 THR B CA  1 ? 
ATOM   4355 C C   . THR B 1 241 ? 7.236   -12.711 33.963 1.00 16.46  ? 264 THR B C   1 ? 
ATOM   4356 O O   . THR B 1 241 ? 7.296   -13.546 33.069 1.00 14.86  ? 264 THR B O   1 ? 
ATOM   4357 C CB  . THR B 1 241 ? 5.244   -11.138 34.304 1.00 16.30  ? 264 THR B CB  1 ? 
ATOM   4358 O OG1 . THR B 1 241 ? 3.956   -11.158 34.906 1.00 18.09  ? 264 THR B OG1 1 ? 
ATOM   4359 C CG2 . THR B 1 241 ? 5.147   -10.923 32.805 1.00 13.09  ? 264 THR B CG2 1 ? 
ATOM   4360 N N   . VAL B 1 242 ? 8.285   -12.011 34.393 1.00 17.32  ? 265 VAL B N   1 ? 
ATOM   4361 C CA  . VAL B 1 242 ? 9.636   -12.185 33.786 1.00 16.91  ? 265 VAL B CA  1 ? 
ATOM   4362 C C   . VAL B 1 242 ? 10.065  -13.656 33.907 1.00 14.32  ? 265 VAL B C   1 ? 
ATOM   4363 O O   . VAL B 1 242 ? 10.468  -14.246 32.914 1.00 19.65  ? 265 VAL B O   1 ? 
ATOM   4364 C CB  . VAL B 1 242 ? 10.633  -11.243 34.480 1.00 20.50  ? 265 VAL B CB  1 ? 
ATOM   4365 C CG1 . VAL B 1 242 ? 12.076  -11.591 34.141 1.00 23.59  ? 265 VAL B CG1 1 ? 
ATOM   4366 C CG2 . VAL B 1 242 ? 10.334  -9.783  34.183 1.00 16.26  ? 265 VAL B CG2 1 ? 
ATOM   4367 N N   . GLN B 1 243 ? 9.902   -14.217 35.086 1.00 15.46  ? 266 GLN B N   1 ? 
ATOM   4368 C CA  . GLN B 1 243 ? 10.273  -15.627 35.327 1.00 14.58  ? 266 GLN B CA  1 ? 
ATOM   4369 C C   . GLN B 1 243 ? 9.502   -16.550 34.377 1.00 17.90  ? 266 GLN B C   1 ? 
ATOM   4370 O O   . GLN B 1 243 ? 10.128  -17.414 33.774 1.00 19.97  ? 266 GLN B O   1 ? 
ATOM   4371 C CB  . GLN B 1 243 ? 9.933   -15.894 36.786 1.00 13.68  ? 266 GLN B CB  1 ? 
ATOM   4372 C CG  . GLN B 1 243 ? 10.812  -15.141 37.777 1.00 17.18  ? 266 GLN B CG  1 ? 
ATOM   4373 C CD  . GLN B 1 243 ? 12.263  -15.568 37.728 1.00 18.10  ? 266 GLN B CD  1 ? 
ATOM   4374 O OE1 . GLN B 1 243 ? 12.590  -16.750 37.859 1.00 17.38  ? 266 GLN B OE1 1 ? 
ATOM   4375 N NE2 . GLN B 1 243 ? 13.151  -14.607 37.536 1.00 13.55  ? 266 GLN B NE2 1 ? 
ATOM   4376 N N   . VAL B 1 244 ? 8.186   -16.347 34.266 1.00 17.89  ? 267 VAL B N   1 ? 
ATOM   4377 C CA  . VAL B 1 244 ? 7.343   -17.250 33.431 1.00 18.82  ? 267 VAL B CA  1 ? 
ATOM   4378 C C   . VAL B 1 244 ? 7.756   -17.106 31.962 1.00 18.29  ? 267 VAL B C   1 ? 
ATOM   4379 O O   . VAL B 1 244 ? 7.995   -18.115 31.314 1.00 14.28  ? 267 VAL B O   1 ? 
ATOM   4380 C CB  . VAL B 1 244 ? 5.846   -16.923 33.596 1.00 20.09  ? 267 VAL B CB  1 ? 
ATOM   4381 C CG1 . VAL B 1 244 ? 4.970   -17.647 32.585 1.00 17.54  ? 267 VAL B CG1 1 ? 
ATOM   4382 C CG2 . VAL B 1 244 ? 5.357   -17.136 35.022 1.00 16.39  ? 267 VAL B CG2 1 ? 
ATOM   4383 N N   . ASN B 1 245 ? 7.817   -15.864 31.492 1.00 15.12  ? 268 ASN B N   1 ? 
ATOM   4384 C CA  . ASN B 1 245 ? 8.115   -15.635 30.057 1.00 18.58  ? 268 ASN B CA  1 ? 
ATOM   4385 C C   . ASN B 1 245 ? 9.486   -16.227 29.702 1.00 22.61  ? 268 ASN B C   1 ? 
ATOM   4386 O O   . ASN B 1 245 ? 9.654   -16.713 28.581 1.00 24.57  ? 268 ASN B O   1 ? 
ATOM   4387 C CB  . ASN B 1 245 ? 8.010   -14.157 29.722 1.00 17.10  ? 268 ASN B CB  1 ? 
ATOM   4388 C CG  . ASN B 1 245 ? 6.603   -13.644 29.907 1.00 24.11  ? 268 ASN B CG  1 ? 
ATOM   4389 O OD1 . ASN B 1 245 ? 5.689   -14.428 30.174 1.00 24.84  ? 268 ASN B OD1 1 ? 
ATOM   4390 N ND2 . ASN B 1 245 ? 6.409   -12.344 29.757 1.00 19.25  ? 268 ASN B ND2 1 ? 
ATOM   4391 N N   . LEU B 1 246 ? 10.421  -16.193 30.646 1.00 18.98  ? 269 LEU B N   1 ? 
ATOM   4392 C CA  . LEU B 1 246 ? 11.771  -16.731 30.349 1.00 26.59  ? 269 LEU B CA  1 ? 
ATOM   4393 C C   . LEU B 1 246 ? 11.707  -18.273 30.302 1.00 27.53  ? 269 LEU B C   1 ? 
ATOM   4394 O O   . LEU B 1 246 ? 12.276  -18.845 29.374 1.00 33.50  ? 269 LEU B O   1 ? 
ATOM   4395 C CB  . LEU B 1 246 ? 12.833  -16.199 31.313 1.00 23.95  ? 269 LEU B CB  1 ? 
ATOM   4396 C CG  . LEU B 1 246 ? 13.171  -14.711 31.231 1.00 23.72  ? 269 LEU B CG  1 ? 
ATOM   4397 C CD1 . LEU B 1 246 ? 14.075  -14.342 32.390 1.00 26.41  ? 269 LEU B CD1 1 ? 
ATOM   4398 C CD2 . LEU B 1 246 ? 13.837  -14.385 29.913 1.00 31.33  ? 269 LEU B CD2 1 ? 
ATOM   4399 N N   . GLU B 1 247 ? 10.994  -18.910 31.225 1.00 25.38  ? 270 GLU B N   1 ? 
ATOM   4400 C CA  . GLU B 1 247 ? 10.996  -20.395 31.285 1.00 23.38  ? 270 GLU B CA  1 ? 
ATOM   4401 C C   . GLU B 1 247 ? 10.070  -21.041 30.234 1.00 26.02  ? 270 GLU B C   1 ? 
ATOM   4402 O O   . GLU B 1 247 ? 10.284  -22.209 29.897 1.00 24.27  ? 270 GLU B O   1 ? 
ATOM   4403 C CB  . GLU B 1 247 ? 10.548  -20.873 32.654 1.00 24.36  ? 270 GLU B CB  1 ? 
ATOM   4404 C CG  . GLU B 1 247 ? 10.857  -22.343 32.900 1.00 35.13  ? 270 GLU B CG  1 ? 
ATOM   4405 C CD  . GLU B 1 247 ? 10.375  -22.874 34.230 1.00 40.26  ? 270 GLU B CD  1 ? 
ATOM   4406 O OE1 . GLU B 1 247 ? 10.569  -24.082 34.449 1.00 31.31  ? 270 GLU B OE1 1 ? 
ATOM   4407 O OE2 . GLU B 1 247 ? 9.813   -22.095 35.027 1.00 37.19  ? 270 GLU B OE2 1 ? 
ATOM   4408 N N   . ALA B 1 248 ? 9.082   -20.304 29.742 1.00 19.92  ? 271 ALA B N   1 ? 
ATOM   4409 C CA  . ALA B 1 248 ? 8.139   -20.859 28.749 1.00 16.47  ? 271 ALA B CA  1 ? 
ATOM   4410 C C   . ALA B 1 248 ? 8.866   -21.517 27.568 1.00 17.98  ? 271 ALA B C   1 ? 
ATOM   4411 O O   . ALA B 1 248 ? 8.528   -22.652 27.246 1.00 18.58  ? 271 ALA B O   1 ? 
ATOM   4412 C CB  . ALA B 1 248 ? 7.197   -19.789 28.296 1.00 14.60  ? 271 ALA B CB  1 ? 
ATOM   4413 N N   . GLU B 1 249 ? 9.821   -20.818 26.959 1.00 20.15  ? 272 GLU B N   1 ? 
ATOM   4414 C CA  . GLU B 1 249 ? 10.528  -21.334 25.756 1.00 23.11  ? 272 GLU B CA  1 ? 
ATOM   4415 C C   . GLU B 1 249 ? 11.266  -22.634 26.093 1.00 16.94  ? 272 GLU B C   1 ? 
ATOM   4416 O O   . GLU B 1 249 ? 11.177  -23.590 25.339 1.00 21.40  ? 272 GLU B O   1 ? 
ATOM   4417 C CB  . GLU B 1 249 ? 11.553  -20.311 25.272 1.00 31.49  ? 272 GLU B CB  1 ? 
ATOM   4418 C CG  . GLU B 1 249 ? 10.987  -19.275 24.306 1.00 52.70  ? 272 GLU B CG  1 ? 
ATOM   4419 C CD  . GLU B 1 249 ? 11.808  -18.003 24.170 1.00 73.04  ? 272 GLU B CD  1 ? 
ATOM   4420 O OE1 . GLU B 1 249 ? 11.228  -16.912 24.344 1.00 68.01  ? 272 GLU B OE1 1 ? 
ATOM   4421 O OE2 . GLU B 1 249 ? 13.023  -18.100 23.898 1.00 63.88  ? 272 GLU B OE2 1 ? 
ATOM   4422 N N   . ARG B 1 250 ? 11.913  -22.648 27.242 1.00 23.13  ? 273 ARG B N   1 ? 
ATOM   4423 C CA  . ARG B 1 250 ? 12.716  -23.828 27.637 1.00 28.59  ? 273 ARG B CA  1 ? 
ATOM   4424 C C   . ARG B 1 250 ? 11.780  -25.011 27.911 1.00 24.84  ? 273 ARG B C   1 ? 
ATOM   4425 O O   . ARG B 1 250 ? 12.050  -26.095 27.404 1.00 22.11  ? 273 ARG B O   1 ? 
ATOM   4426 C CB  . ARG B 1 250 ? 13.562  -23.461 28.854 1.00 27.88  ? 273 ARG B CB  1 ? 
ATOM   4427 C CG  . ARG B 1 250 ? 14.838  -24.276 28.996 1.00 39.95  ? 273 ARG B CG  1 ? 
ATOM   4428 C CD  . ARG B 1 250 ? 15.697  -23.719 30.113 1.00 35.54  ? 273 ARG B CD  1 ? 
ATOM   4429 N NE  . ARG B 1 250 ? 14.932  -22.929 31.082 1.00 30.47  ? 273 ARG B NE  1 ? 
ATOM   4430 C CZ  . ARG B 1 250 ? 14.422  -23.423 32.195 1.00 33.03  ? 273 ARG B CZ  1 ? 
ATOM   4431 N NH1 . ARG B 1 250 ? 14.205  -24.719 32.303 1.00 49.73  ? 273 ARG B NH1 1 ? 
ATOM   4432 N NH2 . ARG B 1 250 ? 14.125  -22.628 33.200 1.00 32.51  ? 273 ARG B NH2 1 ? 
ATOM   4433 N N   . LEU B 1 251 ? 10.719  -24.776 28.687 1.00 21.47  ? 274 LEU B N   1 ? 
ATOM   4434 C CA  . LEU B 1 251 ? 9.787   -25.877 29.034 1.00 21.63  ? 274 LEU B CA  1 ? 
ATOM   4435 C C   . LEU B 1 251 ? 9.194   -26.471 27.741 1.00 19.76  ? 274 LEU B C   1 ? 
ATOM   4436 O O   . LEU B 1 251 ? 9.045   -27.677 27.657 1.00 23.05  ? 274 LEU B O   1 ? 
ATOM   4437 C CB  . LEU B 1 251 ? 8.706   -25.405 30.003 1.00 24.67  ? 274 LEU B CB  1 ? 
ATOM   4438 C CG  . LEU B 1 251 ? 9.069   -25.417 31.488 1.00 30.96  ? 274 LEU B CG  1 ? 
ATOM   4439 C CD1 . LEU B 1 251 ? 7.893   -24.957 32.321 1.00 23.43  ? 274 LEU B CD1 1 ? 
ATOM   4440 C CD2 . LEU B 1 251 ? 9.501   -26.804 31.907 1.00 29.65  ? 274 LEU B CD2 1 ? 
ATOM   4441 N N   . ASN B 1 252 ? 8.912   -25.619 26.767 1.00 19.66  ? 275 ASN B N   1 ? 
ATOM   4442 C CA  . ASN B 1 252 ? 8.346   -26.106 25.483 1.00 19.91  ? 275 ASN B CA  1 ? 
ATOM   4443 C C   . ASN B 1 252 ? 9.390   -26.961 24.739 1.00 22.43  ? 275 ASN B C   1 ? 
ATOM   4444 O O   . ASN B 1 252 ? 9.015   -28.006 24.190 1.00 19.35  ? 275 ASN B O   1 ? 
ATOM   4445 C CB  . ASN B 1 252 ? 7.737   -24.970 24.673 1.00 18.54  ? 275 ASN B CB  1 ? 
ATOM   4446 C CG  . ASN B 1 252 ? 6.328   -24.653 25.117 1.00 24.47  ? 275 ASN B CG  1 ? 
ATOM   4447 O OD1 . ASN B 1 252 ? 5.384   -25.338 24.717 1.00 21.02  ? 275 ASN B OD1 1 ? 
ATOM   4448 N ND2 . ASN B 1 252 ? 6.168   -23.639 25.954 1.00 19.46  ? 275 ASN B ND2 1 ? 
ATOM   4449 N N   . ARG B 1 253 ? 10.645  -26.530 24.724 1.00 22.11  ? 276 ARG B N   1 ? 
ATOM   4450 C CA  . ARG B 1 253 ? 11.714  -27.331 24.070 1.00 22.20  ? 276 ARG B CA  1 ? 
ATOM   4451 C C   . ARG B 1 253 ? 11.824  -28.686 24.787 1.00 20.42  ? 276 ARG B C   1 ? 
ATOM   4452 O O   . ARG B 1 253 ? 11.877  -29.716 24.122 1.00 23.42  ? 276 ARG B O   1 ? 
ATOM   4453 C CB  . ARG B 1 253 ? 13.050  -26.583 24.008 1.00 22.43  ? 276 ARG B CB  1 ? 
ATOM   4454 C CG  . ARG B 1 253 ? 13.034  -25.384 23.074 1.00 27.29  ? 276 ARG B CG  1 ? 
ATOM   4455 C CD  . ARG B 1 253 ? 14.423  -24.828 22.800 1.00 30.10  ? 276 ARG B CD  1 ? 
ATOM   4456 N NE  . ARG B 1 253 ? 15.173  -24.564 24.031 1.00 32.83  ? 276 ARG B NE  1 ? 
ATOM   4457 C CZ  . ARG B 1 253 ? 15.313  -23.371 24.582 1.00 41.95  ? 276 ARG B CZ  1 ? 
ATOM   4458 N NH1 . ARG B 1 253 ? 14.575  -22.363 24.164 1.00 52.13  ? 276 ARG B NH1 1 ? 
ATOM   4459 N NH2 . ARG B 1 253 ? 16.193  -23.184 25.547 1.00 35.40  ? 276 ARG B NH2 1 ? 
ATOM   4460 N N   . ASP B 1 254 ? 11.802  -28.659 26.108 1.00 21.90  ? 277 ASP B N   1 ? 
ATOM   4461 C CA  . ASP B 1 254 ? 11.889  -29.928 26.877 1.00 24.44  ? 277 ASP B CA  1 ? 
ATOM   4462 C C   . ASP B 1 254 ? 10.693  -30.807 26.536 1.00 21.32  ? 277 ASP B C   1 ? 
ATOM   4463 O O   . ASP B 1 254 ? 10.865  -32.018 26.427 1.00 24.51  ? 277 ASP B O   1 ? 
ATOM   4464 C CB  . ASP B 1 254 ? 11.962  -29.716 28.371 1.00 21.51  ? 277 ASP B CB  1 ? 
ATOM   4465 C CG  . ASP B 1 254 ? 12.144  -30.998 29.165 1.00 31.36  ? 277 ASP B CG  1 ? 
ATOM   4466 O OD1 . ASP B 1 254 ? 13.039  -31.780 28.801 1.00 36.43  ? 277 ASP B OD1 1 ? 
ATOM   4467 O OD2 . ASP B 1 254 ? 11.376  -31.212 30.114 1.00 33.40  ? 277 ASP B OD2 1 ? 
ATOM   4468 N N   . ALA B 1 255 ? 9.530   -30.191 26.377 1.00 17.10  ? 278 ALA B N   1 ? 
ATOM   4469 C CA  . ALA B 1 255 ? 8.305   -30.953 26.076 1.00 20.57  ? 278 ALA B CA  1 ? 
ATOM   4470 C C   . ALA B 1 255 ? 8.424   -31.591 24.686 1.00 23.09  ? 278 ALA B C   1 ? 
ATOM   4471 O O   . ALA B 1 255 ? 8.138   -32.788 24.555 1.00 22.60  ? 278 ALA B O   1 ? 
ATOM   4472 C CB  . ALA B 1 255 ? 7.125   -30.032 26.198 1.00 20.01  ? 278 ALA B CB  1 ? 
ATOM   4473 N N   . ARG B 1 256 ? 8.844   -30.814 23.698 1.00 18.41  ? 279 ARG B N   1 ? 
ATOM   4474 C CA  . ARG B 1 256 ? 9.034   -31.335 22.323 1.00 21.17  ? 279 ARG B CA  1 ? 
ATOM   4475 C C   . ARG B 1 256 ? 9.957   -32.559 22.332 1.00 23.13  ? 279 ARG B C   1 ? 
ATOM   4476 O O   . ARG B 1 256 ? 9.623   -33.544 21.677 1.00 27.38  ? 279 ARG B O   1 ? 
ATOM   4477 C CB  . ARG B 1 256 ? 9.666   -30.276 21.425 1.00 20.92  ? 279 ARG B CB  1 ? 
ATOM   4478 C CG  . ARG B 1 256 ? 9.607   -30.607 19.945 1.00 23.27  ? 279 ARG B CG  1 ? 
ATOM   4479 C CD  . ARG B 1 256 ? 10.417  -29.617 19.135 1.00 24.99  ? 279 ARG B CD  1 ? 
ATOM   4480 N NE  . ARG B 1 256 ? 10.307  -29.838 17.690 1.00 24.00  ? 279 ARG B NE  1 ? 
ATOM   4481 C CZ  . ARG B 1 256 ? 10.871  -30.817 17.000 1.00 24.58  ? 279 ARG B CZ  1 ? 
ATOM   4482 N NH1 . ARG B 1 256 ? 11.584  -31.749 17.607 1.00 22.78  ? 279 ARG B NH1 1 ? 
ATOM   4483 N NH2 . ARG B 1 256 ? 10.719  -30.860 15.693 1.00 22.80  ? 279 ARG B NH2 1 ? 
ATOM   4484 N N   . GLN B 1 257 ? 11.046  -32.501 23.096 1.00 25.44  ? 280 GLN B N   1 ? 
ATOM   4485 C CA  . GLN B 1 257 ? 12.035  -33.611 23.063 1.00 24.53  ? 280 GLN B CA  1 ? 
ATOM   4486 C C   . GLN B 1 257 ? 11.470  -34.840 23.781 1.00 26.09  ? 280 GLN B C   1 ? 
ATOM   4487 O O   . GLN B 1 257 ? 11.724  -35.948 23.309 1.00 28.52  ? 280 GLN B O   1 ? 
ATOM   4488 C CB  . GLN B 1 257 ? 13.413  -33.208 23.589 1.00 24.16  ? 280 GLN B CB  1 ? 
ATOM   4489 C CG  . GLN B 1 257 ? 13.550  -32.965 25.086 1.00 30.03  ? 280 GLN B CG  1 ? 
ATOM   4490 C CD  . GLN B 1 257 ? 14.931  -32.469 25.461 1.00 41.73  ? 280 GLN B CD  1 ? 
ATOM   4491 O OE1 . GLN B 1 257 ? 15.191  -32.062 26.597 1.00 45.20  ? 280 GLN B OE1 1 ? 
ATOM   4492 N NE2 . GLN B 1 257 ? 15.840  -32.496 24.499 1.00 39.35  ? 280 GLN B NE2 1 ? 
ATOM   4493 N N   . ARG B 1 258 ? 10.730  -34.638 24.865 1.00 20.63  ? 281 ARG B N   1 ? 
ATOM   4494 C CA  . ARG B 1 258 ? 10.096  -35.801 25.525 1.00 24.37  ? 281 ARG B CA  1 ? 
ATOM   4495 C C   . ARG B 1 258 ? 9.074   -36.444 24.570 1.00 31.74  ? 281 ARG B C   1 ? 
ATOM   4496 O O   . ARG B 1 258 ? 8.990   -37.671 24.557 1.00 33.83  ? 281 ARG B O   1 ? 
ATOM   4497 C CB  . ARG B 1 258 ? 9.470   -35.498 26.883 1.00 22.57  ? 281 ARG B CB  1 ? 
ATOM   4498 C CG  . ARG B 1 258 ? 10.460  -34.914 27.877 1.00 26.08  ? 281 ARG B CG  1 ? 
ATOM   4499 C CD  . ARG B 1 258 ? 9.740   -34.372 29.094 1.00 29.44  ? 281 ARG B CD  1 ? 
ATOM   4500 N NE  . ARG B 1 258 ? 10.679  -33.988 30.150 1.00 43.67  ? 281 ARG B NE  1 ? 
ATOM   4501 C CZ  . ARG B 1 258 ? 11.182  -34.810 31.060 1.00 52.56  ? 281 ARG B CZ  1 ? 
ATOM   4502 N NH1 . ARG B 1 258 ? 12.047  -34.355 31.948 1.00 43.60  ? 281 ARG B NH1 1 ? 
ATOM   4503 N NH2 . ARG B 1 258 ? 10.816  -36.077 31.086 1.00 40.15  ? 281 ARG B NH2 1 ? 
ATOM   4504 N N   . ILE B 1 259 ? 8.362   -35.631 23.791 1.00 26.92  ? 282 ILE B N   1 ? 
ATOM   4505 C CA  . ILE B 1 259 ? 7.342   -36.198 22.862 1.00 35.20  ? 282 ILE B CA  1 ? 
ATOM   4506 C C   . ILE B 1 259 ? 8.086   -37.039 21.819 1.00 34.49  ? 282 ILE B C   1 ? 
ATOM   4507 O O   . ILE B 1 259 ? 7.620   -38.131 21.490 1.00 28.71  ? 282 ILE B O   1 ? 
ATOM   4508 C CB  . ILE B 1 259 ? 6.454   -35.110 22.227 1.00 26.10  ? 282 ILE B CB  1 ? 
ATOM   4509 C CG1 . ILE B 1 259 ? 5.550   -34.465 23.272 1.00 21.94  ? 282 ILE B CG1 1 ? 
ATOM   4510 C CG2 . ILE B 1 259 ? 5.653   -35.654 21.045 1.00 21.08  ? 282 ILE B CG2 1 ? 
ATOM   4511 C CD1 . ILE B 1 259 ? 4.904   -33.171 22.821 1.00 21.11  ? 282 ILE B CD1 1 ? 
ATOM   4512 N N   . LEU B 1 260 ? 9.222   -36.530 21.352 1.00 31.68  ? 283 LEU B N   1 ? 
ATOM   4513 C CA  . LEU B 1 260 ? 9.994   -37.267 20.324 1.00 32.77  ? 283 LEU B CA  1 ? 
ATOM   4514 C C   . LEU B 1 260 ? 10.561  -38.558 20.952 1.00 33.97  ? 283 LEU B C   1 ? 
ATOM   4515 O O   . LEU B 1 260 ? 10.406  -39.620 20.353 1.00 34.25  ? 283 LEU B O   1 ? 
ATOM   4516 C CB  . LEU B 1 260 ? 11.044  -36.335 19.724 1.00 28.79  ? 283 LEU B CB  1 ? 
ATOM   4517 C CG  . LEU B 1 260 ? 11.672  -36.780 18.403 1.00 36.41  ? 283 LEU B CG  1 ? 
ATOM   4518 C CD1 . LEU B 1 260 ? 10.574  -37.096 17.414 1.00 41.60  ? 283 LEU B CD1 1 ? 
ATOM   4519 C CD2 . LEU B 1 260 ? 12.599  -35.708 17.859 1.00 32.66  ? 283 LEU B CD2 1 ? 
ATOM   4520 N N   . ALA B 1 261 ? 11.096  -38.479 22.166 1.00 38.59  ? 284 ALA B N   1 ? 
ATOM   4521 C CA  . ALA B 1 261 ? 11.737  -39.656 22.802 1.00 39.96  ? 284 ALA B CA  1 ? 
ATOM   4522 C C   . ALA B 1 261 ? 10.713  -40.726 23.173 1.00 44.82  ? 284 ALA B C   1 ? 
ATOM   4523 O O   . ALA B 1 261 ? 11.134  -41.824 23.553 1.00 42.25  ? 284 ALA B O   1 ? 
ATOM   4524 C CB  . ALA B 1 261 ? 12.503  -39.247 24.025 1.00 26.79  ? 284 ALA B CB  1 ? 
ATOM   4525 N N   . SER B 1 262 ? 9.426   -40.387 23.139 1.00 46.38  ? 285 SER B N   1 ? 
ATOM   4526 C CA  . SER B 1 262 ? 8.379   -41.353 23.561 1.00 47.50  ? 285 SER B CA  1 ? 
ATOM   4527 C C   . SER B 1 262 ? 8.431   -42.572 22.639 1.00 40.06  ? 285 SER B C   1 ? 
ATOM   4528 O O   . SER B 1 262 ? 8.333   -43.695 23.148 1.00 38.87  ? 285 SER B O   1 ? 
ATOM   4529 C CB  . SER B 1 262 ? 7.028   -40.710 23.518 1.00 39.92  ? 285 SER B CB  1 ? 
ATOM   4530 O OG  . SER B 1 262 ? 6.611   -40.500 22.178 1.00 36.53  ? 285 SER B OG  1 ? 
ATOM   4531 N N   . GLY B 1 263 ? 8.579   -42.327 21.339 1.00 41.40  ? 286 GLY B N   1 ? 
ATOM   4532 C CA  . GLY B 1 263 ? 8.621   -43.399 20.333 1.00 39.99  ? 286 GLY B CA  1 ? 
ATOM   4533 C C   . GLY B 1 263 ? 7.247   -43.646 19.754 1.00 48.12  ? 286 GLY B C   1 ? 
ATOM   4534 O O   . GLY B 1 263 ? 7.169   -44.217 18.657 1.00 55.34  ? 286 GLY B O   1 ? 
ATOM   4535 N N   . ALA B 1 264 ? 6.204   -43.197 20.439 1.00 41.40  ? 287 ALA B N   1 ? 
ATOM   4536 C CA  . ALA B 1 264 ? 4.824   -43.502 20.010 1.00 39.45  ? 287 ALA B CA  1 ? 
ATOM   4537 C C   . ALA B 1 264 ? 4.216   -42.335 19.227 1.00 37.57  ? 287 ALA B C   1 ? 
ATOM   4538 O O   . ALA B 1 264 ? 3.073   -42.439 18.781 1.00 31.26  ? 287 ALA B O   1 ? 
ATOM   4539 C CB  . ALA B 1 264 ? 4.030   -43.820 21.241 1.00 35.56  ? 287 ALA B CB  1 ? 
ATOM   4540 N N   . SER B 1 265 ? 4.979   -41.262 19.070 1.00 28.29  ? 288 SER B N   1 ? 
ATOM   4541 C CA  . SER B 1 265 ? 4.503   -40.111 18.275 1.00 34.73  ? 288 SER B CA  1 ? 
ATOM   4542 C C   . SER B 1 265 ? 5.621   -39.610 17.350 1.00 30.10  ? 288 SER B C   1 ? 
ATOM   4543 O O   . SER B 1 265 ? 6.787   -39.651 17.747 1.00 33.95  ? 288 SER B O   1 ? 
ATOM   4544 C CB  . SER B 1 265 ? 3.935   -38.999 19.155 1.00 26.67  ? 288 SER B CB  1 ? 
ATOM   4545 O OG  . SER B 1 265 ? 2.810   -39.439 19.898 1.00 33.37  ? 288 SER B OG  1 ? 
ATOM   4546 N N   . GLU B 1 266 ? 5.250   -39.169 16.160 1.00 31.08  ? 289 GLU B N   1 ? 
ATOM   4547 C CA  . GLU B 1 266 ? 6.238   -38.598 15.227 1.00 34.68  ? 289 GLU B CA  1 ? 
ATOM   4548 C C   . GLU B 1 266 ? 6.055   -37.084 15.149 1.00 37.09  ? 289 GLU B C   1 ? 
ATOM   4549 O O   . GLU B 1 266 ? 4.939   -36.614 15.373 1.00 33.81  ? 289 GLU B O   1 ? 
ATOM   4550 C CB  . GLU B 1 266 ? 6.019   -39.079 13.800 1.00 33.95  ? 289 GLU B CB  1 ? 
ATOM   4551 C CG  . GLU B 1 266 ? 6.012   -40.596 13.652 1.00 40.96  ? 289 GLU B CG  1 ? 
ATOM   4552 C CD  . GLU B 1 266 ? 6.021   -41.009 12.193 1.00 49.27  ? 289 GLU B CD  1 ? 
ATOM   4553 O OE1 . GLU B 1 266 ? 6.007   -42.225 11.920 1.00 56.76  ? 289 GLU B OE1 1 ? 
ATOM   4554 O OE2 . GLU B 1 266 ? 6.041   -40.112 11.329 1.00 42.44  ? 289 GLU B OE2 1 ? 
ATOM   4555 N N   . ILE B 1 267 ? 7.119   -36.366 14.810 1.00 32.01  ? 290 ILE B N   1 ? 
ATOM   4556 C CA  . ILE B 1 267 ? 6.987   -34.896 14.613 1.00 27.20  ? 290 ILE B CA  1 ? 
ATOM   4557 C C   . ILE B 1 267 ? 7.469   -34.527 13.201 1.00 32.29  ? 290 ILE B C   1 ? 
ATOM   4558 O O   . ILE B 1 267 ? 8.635   -34.808 12.887 1.00 35.57  ? 290 ILE B O   1 ? 
ATOM   4559 C CB  . ILE B 1 267 ? 7.714   -34.079 15.696 1.00 21.80  ? 290 ILE B CB  1 ? 
ATOM   4560 C CG1 . ILE B 1 267 ? 7.312   -34.502 17.107 1.00 25.15  ? 290 ILE B CG1 1 ? 
ATOM   4561 C CG2 . ILE B 1 267 ? 7.509   -32.582 15.471 1.00 21.46  ? 290 ILE B CG2 1 ? 
ATOM   4562 C CD1 . ILE B 1 267 ? 8.069   -33.783 18.207 1.00 26.04  ? 290 ILE B CD1 1 ? 
ATOM   4563 N N   . HIS B 1 268 ? 6.594   -33.951 12.397 1.00 25.32  ? 291 HIS B N   1 ? 
ATOM   4564 C CA  . HIS B 1 268 ? 7.032   -33.428 11.085 1.00 32.66  ? 291 HIS B CA  1 ? 
ATOM   4565 C C   . HIS B 1 268 ? 7.197   -31.917 11.224 1.00 40.40  ? 291 HIS B C   1 ? 
ATOM   4566 O O   . HIS B 1 268 ? 6.224   -31.221 11.527 1.00 37.10  ? 291 HIS B O   1 ? 
ATOM   4567 C CB  . HIS B 1 268 ? 6.035   -33.725 9.973  1.00 30.02  ? 291 HIS B CB  1 ? 
ATOM   4568 C CG  . HIS B 1 268 ? 6.344   -33.006 8.708  1.00 41.41  ? 291 HIS B CG  1 ? 
ATOM   4569 N ND1 . HIS B 1 268 ? 5.623   -31.916 8.279  1.00 50.14  ? 291 HIS B ND1 1 ? 
ATOM   4570 C CD2 . HIS B 1 268 ? 7.283   -33.215 7.786  1.00 38.07  ? 291 HIS B CD2 1 ? 
ATOM   4571 C CE1 . HIS B 1 268 ? 6.119   -31.493 7.131  1.00 40.56  ? 291 HIS B CE1 1 ? 
ATOM   4572 N NE2 . HIS B 1 268 ? 7.130   -32.264 6.816  1.00 44.60  ? 291 HIS B NE2 1 ? 
ATOM   4573 N N   . THR B 1 269 ? 8.415   -31.434 11.014 1.00 34.57  ? 292 THR B N   1 ? 
ATOM   4574 C CA  . THR B 1 269 ? 8.653   -29.989 11.049 1.00 39.60  ? 292 THR B CA  1 ? 
ATOM   4575 C C   . THR B 1 269 ? 8.351   -29.438 9.677  1.00 38.57  ? 292 THR B C   1 ? 
ATOM   4576 O O   . THR B 1 269 ? 8.939   -29.914 8.698  1.00 34.41  ? 292 THR B O   1 ? 
ATOM   4577 C CB  . THR B 1 269 ? 10.075  -29.695 11.516 1.00 32.71  ? 292 THR B CB  1 ? 
ATOM   4578 O OG1 . THR B 1 269 ? 10.128  -30.093 12.879 1.00 34.84  ? 292 THR B OG1 1 ? 
ATOM   4579 C CG2 . THR B 1 269 ? 10.424  -28.223 11.410 1.00 37.82  ? 292 THR B CG2 1 ? 
ATOM   4580 N N   . LEU B 1 270 ? 7.438   -28.474 9.614  1.00 33.86  ? 293 LEU B N   1 ? 
ATOM   4581 C CA  . LEU B 1 270 ? 7.034   -27.931 8.300  1.00 31.29  ? 293 LEU B CA  1 ? 
ATOM   4582 C C   . LEU B 1 270 ? 8.223   -27.238 7.646  1.00 35.23  ? 293 LEU B C   1 ? 
ATOM   4583 O O   . LEU B 1 270 ? 8.945   -26.518 8.343  1.00 34.23  ? 293 LEU B O   1 ? 
ATOM   4584 C CB  . LEU B 1 270 ? 5.869   -26.948 8.355  1.00 31.53  ? 293 LEU B CB  1 ? 
ATOM   4585 C CG  . LEU B 1 270 ? 4.461   -27.527 8.488  1.00 29.15  ? 293 LEU B CG  1 ? 
ATOM   4586 C CD1 . LEU B 1 270 ? 3.479   -26.379 8.409  1.00 27.76  ? 293 LEU B CD1 1 ? 
ATOM   4587 C CD2 . LEU B 1 270 ? 4.201   -28.527 7.388  1.00 29.33  ? 293 LEU B CD2 1 ? 
ATOM   4588 N N   . SER B 1 271 ? 8.373   -27.447 6.343  1.00 38.41  ? 294 SER B N   1 ? 
ATOM   4589 C CA  . SER B 1 271 ? 9.376   -26.711 5.556  1.00 40.90  ? 294 SER B CA  1 ? 
ATOM   4590 C C   . SER B 1 271 ? 8.922   -25.259 5.435  1.00 41.60  ? 294 SER B C   1 ? 
ATOM   4591 O O   . SER B 1 271 ? 7.726   -24.992 5.611  1.00 43.24  ? 294 SER B O   1 ? 
ATOM   4592 C CB  . SER B 1 271 ? 9.461   -27.307 4.193  1.00 33.61  ? 294 SER B CB  1 ? 
ATOM   4593 O OG  . SER B 1 271 ? 8.473   -26.756 3.338  1.00 36.43  ? 294 SER B OG  1 ? 
ATOM   4594 N N   . PRO B 1 272 ? 9.820   -24.318 5.100  1.00 46.40  ? 295 PRO B N   1 ? 
ATOM   4595 C CA  . PRO B 1 272 ? 9.400   -22.949 4.846  1.00 42.28  ? 295 PRO B CA  1 ? 
ATOM   4596 C C   . PRO B 1 272 ? 8.278   -22.821 3.827  1.00 43.10  ? 295 PRO B C   1 ? 
ATOM   4597 O O   . PRO B 1 272 ? 7.359   -22.007 3.997  1.00 37.57  ? 295 PRO B O   1 ? 
ATOM   4598 C CB  . PRO B 1 272 ? 10.721  -22.389 4.326  1.00 39.28  ? 295 PRO B CB  1 ? 
ATOM   4599 C CG  . PRO B 1 272 ? 11.754  -23.091 5.155  1.00 37.02  ? 295 PRO B CG  1 ? 
ATOM   4600 C CD  . PRO B 1 272 ? 11.259  -24.514 5.070  1.00 40.59  ? 295 PRO B CD  1 ? 
ATOM   4601 N N   . GLN B 1 273 ? 8.346   -23.622 2.772  1.00 45.70  ? 296 GLN B N   1 ? 
ATOM   4602 C CA  . GLN B 1 273 ? 7.341   -23.540 1.691  1.00 43.98  ? 296 GLN B CA  1 ? 
ATOM   4603 C C   . GLN B 1 273 ? 6.029   -24.185 2.130  1.00 41.72  ? 296 GLN B C   1 ? 
ATOM   4604 O O   . GLN B 1 273 ? 4.978   -23.608 1.854  1.00 48.06  ? 296 GLN B O   1 ? 
ATOM   4605 C CB  . GLN B 1 273 ? 7.897   -24.291 0.488  1.00 66.46  ? 296 GLN B CB  1 ? 
ATOM   4606 C CG  . GLN B 1 273 ? 9.216   -23.727 -0.032 1.00 61.31  ? 296 GLN B CG  1 ? 
ATOM   4607 C CD  . GLN B 1 273 ? 10.433  -24.478 0.461  1.00 66.54  ? 296 GLN B CD  1 ? 
ATOM   4608 O OE1 . GLN B 1 273 ? 10.545  -24.830 1.639  1.00 60.32  ? 296 GLN B OE1 1 ? 
ATOM   4609 N NE2 . GLN B 1 273 ? 11.366  -24.722 -0.445 1.00 82.86  ? 296 GLN B NE2 1 ? 
ATOM   4610 N N   . GLN B 1 274 ? 6.095   -25.352 2.754  1.00 41.02  ? 297 GLN B N   1 ? 
ATOM   4611 C CA  . GLN B 1 274 ? 4.859   -25.968 3.299  1.00 38.49  ? 297 GLN B CA  1 ? 
ATOM   4612 C C   . GLN B 1 274 ? 4.175   -24.970 4.251  1.00 36.38  ? 297 GLN B C   1 ? 
ATOM   4613 O O   . GLN B 1 274 ? 2.955   -24.832 4.193  1.00 33.96  ? 297 GLN B O   1 ? 
ATOM   4614 C CB  . GLN B 1 274 ? 5.171   -27.256 4.049  1.00 42.30  ? 297 GLN B CB  1 ? 
ATOM   4615 C CG  . GLN B 1 274 ? 5.420   -28.490 3.198  1.00 37.61  ? 297 GLN B CG  1 ? 
ATOM   4616 C CD  . GLN B 1 274 ? 5.928   -29.638 4.038  1.00 36.14  ? 297 GLN B CD  1 ? 
ATOM   4617 O OE1 . GLN B 1 274 ? 6.712   -29.445 4.972  1.00 37.53  ? 297 GLN B OE1 1 ? 
ATOM   4618 N NE2 . GLN B 1 274 ? 5.468   -30.840 3.731  1.00 38.69  ? 297 GLN B NE2 1 ? 
ATOM   4619 N N   . ARG B 1 275 ? 4.955   -24.296 5.094  1.00 34.02  ? 298 ARG B N   1 ? 
ATOM   4620 C CA  . ARG B 1 275 ? 4.379   -23.318 6.048  1.00 36.65  ? 298 ARG B CA  1 ? 
ATOM   4621 C C   . ARG B 1 275 ? 3.699   -22.196 5.256  1.00 33.37  ? 298 ARG B C   1 ? 
ATOM   4622 O O   . ARG B 1 275 ? 2.603   -21.767 5.634  1.00 32.41  ? 298 ARG B O   1 ? 
ATOM   4623 C CB  . ARG B 1 275 ? 5.440   -22.807 7.026  1.00 36.94  ? 298 ARG B CB  1 ? 
ATOM   4624 C CG  . ARG B 1 275 ? 4.921   -21.980 8.193  1.00 32.10  ? 298 ARG B CG  1 ? 
ATOM   4625 C CD  . ARG B 1 275 ? 5.891   -22.028 9.362  1.00 42.58  ? 298 ARG B CD  1 ? 
ATOM   4626 N NE  . ARG B 1 275 ? 5.418   -21.338 10.566 1.00 46.86  ? 298 ARG B NE  1 ? 
ATOM   4627 C CZ  . ARG B 1 275 ? 5.503   -20.032 10.779 1.00 51.38  ? 298 ARG B CZ  1 ? 
ATOM   4628 N NH1 . ARG B 1 275 ? 5.875   -19.227 9.803  1.00 52.46  ? 298 ARG B NH1 1 ? 
ATOM   4629 N NH2 . ARG B 1 275 ? 5.206   -19.530 11.963 1.00 43.62  ? 298 ARG B NH2 1 ? 
ATOM   4630 N N   . ALA B 1 276 ? 4.329   -21.768 4.171  1.00 29.11  ? 299 ALA B N   1 ? 
ATOM   4631 C CA  . ALA B 1 276 ? 3.732   -20.699 3.343  1.00 32.20  ? 299 ALA B CA  1 ? 
ATOM   4632 C C   . ALA B 1 276 ? 2.373   -21.128 2.786  1.00 32.59  ? 299 ALA B C   1 ? 
ATOM   4633 O O   . ALA B 1 276 ? 1.450   -20.312 2.745  1.00 35.60  ? 299 ALA B O   1 ? 
ATOM   4634 C CB  . ALA B 1 276 ? 4.685   -20.306 2.247  1.00 33.04  ? 299 ALA B CB  1 ? 
ATOM   4635 N N   . ASP B 1 277 ? 2.256   -22.387 2.376  1.00 32.81  ? 300 ASP B N   1 ? 
ATOM   4636 C CA  . ASP B 1 277 ? 0.971   -22.883 1.823  1.00 34.67  ? 300 ASP B CA  1 ? 
ATOM   4637 C C   . ASP B 1 277 ? -0.068  -23.046 2.945  1.00 32.14  ? 300 ASP B C   1 ? 
ATOM   4638 O O   . ASP B 1 277 ? -1.231  -22.704 2.722  1.00 33.29  ? 300 ASP B O   1 ? 
ATOM   4639 C CB  . ASP B 1 277 ? 1.173   -24.120 0.967  1.00 38.47  ? 300 ASP B CB  1 ? 
ATOM   4640 C CG  . ASP B 1 277 ? 2.095   -23.940 -0.228 1.00 45.91  ? 300 ASP B CG  1 ? 
ATOM   4641 O OD1 . ASP B 1 277 ? 2.107   -22.829 -0.794 1.00 51.84  ? 300 ASP B OD1 1 ? 
ATOM   4642 O OD2 . ASP B 1 277 ? 2.793   -24.910 -0.576 1.00 40.91  ? 300 ASP B OD2 1 ? 
ATOM   4643 N N   . TRP B 1 278 ? 0.339   -23.525 4.113  1.00 28.81  ? 301 TRP B N   1 ? 
ATOM   4644 C CA  . TRP B 1 278 ? -0.632  -23.600 5.229  1.00 31.29  ? 301 TRP B CA  1 ? 
ATOM   4645 C C   . TRP B 1 278 ? -1.155  -22.189 5.514  1.00 28.54  ? 301 TRP B C   1 ? 
ATOM   4646 O O   . TRP B 1 278 ? -2.354  -22.029 5.671  1.00 30.22  ? 301 TRP B O   1 ? 
ATOM   4647 C CB  . TRP B 1 278 ? -0.002  -24.236 6.470  1.00 29.65  ? 301 TRP B CB  1 ? 
ATOM   4648 C CG  . TRP B 1 278 ? 0.076   -25.737 6.448  1.00 23.35  ? 301 TRP B CG  1 ? 
ATOM   4649 C CD1 . TRP B 1 278 ? 1.072   -26.501 5.922  1.00 26.69  ? 301 TRP B CD1 1 ? 
ATOM   4650 C CD2 . TRP B 1 278 ? -0.879  -26.657 7.015  1.00 26.97  ? 301 TRP B CD2 1 ? 
ATOM   4651 N NE1 . TRP B 1 278 ? 0.806   -27.828 6.115  1.00 27.58  ? 301 TRP B NE1 1 ? 
ATOM   4652 C CE2 . TRP B 1 278 ? -0.382  -27.955 6.783  1.00 27.56  ? 301 TRP B CE2 1 ? 
ATOM   4653 C CE3 . TRP B 1 278 ? -2.094  -26.511 7.689  1.00 25.00  ? 301 TRP B CE3 1 ? 
ATOM   4654 C CZ2 . TRP B 1 278 ? -1.060  -29.094 7.205  1.00 29.78  ? 301 TRP B CZ2 1 ? 
ATOM   4655 C CZ3 . TRP B 1 278 ? -2.768  -27.638 8.095  1.00 27.89  ? 301 TRP B CZ3 1 ? 
ATOM   4656 C CH2 . TRP B 1 278 ? -2.253  -28.911 7.863  1.00 33.83  ? 301 TRP B CH2 1 ? 
ATOM   4657 N N   . ARG B 1 279 ? -0.265  -21.203 5.489  1.00 31.98  ? 302 ARG B N   1 ? 
ATOM   4658 C CA  . ARG B 1 279 ? -0.662  -19.794 5.729  1.00 32.91  ? 302 ARG B CA  1 ? 
ATOM   4659 C C   . ARG B 1 279 ? -1.652  -19.319 4.659  1.00 37.13  ? 302 ARG B C   1 ? 
ATOM   4660 O O   . ARG B 1 279 ? -2.621  -18.648 5.004  1.00 28.80  ? 302 ARG B O   1 ? 
ATOM   4661 C CB  . ARG B 1 279 ? 0.583   -18.909 5.708  1.00 37.44  ? 302 ARG B CB  1 ? 
ATOM   4662 C CG  . ARG B 1 279 ? 0.289   -17.445 5.997  1.00 37.49  ? 302 ARG B CG  1 ? 
ATOM   4663 C CD  . ARG B 1 279 ? 1.498   -16.651 6.441  1.00 36.07  ? 302 ARG B CD  1 ? 
ATOM   4664 N NE  . ARG B 1 279 ? 1.144   -15.237 6.602  1.00 55.29  ? 302 ARG B NE  1 ? 
ATOM   4665 C CZ  . ARG B 1 279 ? 1.566   -14.447 7.582  1.00 69.63  ? 302 ARG B CZ  1 ? 
ATOM   4666 N NH1 . ARG B 1 279 ? 2.615   -14.794 8.305  1.00 67.41  ? 302 ARG B NH1 1 ? 
ATOM   4667 N NH2 . ARG B 1 279 ? 0.937   -13.313 7.834  1.00 48.71  ? 302 ARG B NH2 1 ? 
ATOM   4668 N N   . GLN B 1 280 ? -1.378  -19.660 3.401  1.00 40.15  ? 303 GLN B N   1 ? 
ATOM   4669 C CA  . GLN B 1 280 ? -2.251  -19.207 2.294  1.00 42.48  ? 303 GLN B CA  1 ? 
ATOM   4670 C C   . GLN B 1 280 ? -3.640  -19.817 2.476  1.00 30.56  ? 303 GLN B C   1 ? 
ATOM   4671 O O   . GLN B 1 280 ? -4.616  -19.113 2.264  1.00 34.04  ? 303 GLN B O   1 ? 
ATOM   4672 C CB  . GLN B 1 280 ? -1.596  -19.613 0.973  1.00 52.36  ? 303 GLN B CB  1 ? 
ATOM   4673 C CG  . GLN B 1 280 ? -2.544  -19.661 -0.217 1.00 62.41  ? 303 GLN B CG  1 ? 
ATOM   4674 C CD  . GLN B 1 280 ? -1.811  -19.891 -1.517 1.00 74.36  ? 303 GLN B CD  1 ? 
ATOM   4675 O OE1 . GLN B 1 280 ? -1.506  -18.950 -2.257 1.00 79.77  ? 303 GLN B OE1 1 ? 
ATOM   4676 N NE2 . GLN B 1 280 ? -1.501  -21.148 -1.794 1.00 67.73  ? 303 GLN B NE2 1 ? 
ATOM   4677 N N   . ALA B 1 281 ? -3.688  -21.082 2.863  1.00 27.46  ? 304 ALA B N   1 ? 
ATOM   4678 C CA  . ALA B 1 281 ? -4.967  -21.783 3.084  1.00 29.08  ? 304 ALA B CA  1 ? 
ATOM   4679 C C   . ALA B 1 281 ? -5.705  -21.272 4.318  1.00 33.40  ? 304 ALA B C   1 ? 
ATOM   4680 O O   . ALA B 1 281 ? -6.935  -21.234 4.274  1.00 30.44  ? 304 ALA B O   1 ? 
ATOM   4681 C CB  . ALA B 1 281 ? -4.678  -23.240 3.256  1.00 28.21  ? 304 ALA B CB  1 ? 
ATOM   4682 N N   . MET B 1 282 ? -4.975  -20.885 5.362  1.00 31.67  ? 305 MET B N   1 ? 
ATOM   4683 C CA  . MET B 1 282 ? -5.628  -20.539 6.653  1.00 34.06  ? 305 MET B CA  1 ? 
ATOM   4684 C C   . MET B 1 282 ? -5.926  -19.034 6.799  1.00 36.08  ? 305 MET B C   1 ? 
ATOM   4685 O O   . MET B 1 282 ? -6.882  -18.710 7.504  1.00 39.35  ? 305 MET B O   1 ? 
ATOM   4686 C CB  . MET B 1 282 ? -4.739  -21.033 7.798  1.00 28.41  ? 305 MET B CB  1 ? 
ATOM   4687 C CG  . MET B 1 282 ? -4.658  -22.540 7.873  1.00 32.94  ? 305 MET B CG  1 ? 
ATOM   4688 S SD  . MET B 1 282 ? -3.393  -23.122 9.017  1.00 41.57  ? 305 MET B SD  1 ? 
ATOM   4689 C CE  . MET B 1 282 ? -4.002  -22.358 10.523 1.00 26.63  ? 305 MET B CE  1 ? 
ATOM   4690 N N   . GLN B 1 283 ? -5.184  -18.161 6.129  1.00 33.70  ? 306 GLN B N   1 ? 
ATOM   4691 C CA  . GLN B 1 283 ? -5.328  -16.693 6.347  1.00 41.86  ? 306 GLN B CA  1 ? 
ATOM   4692 C C   . GLN B 1 283 ? -6.653  -16.061 5.868  1.00 37.77  ? 306 GLN B C   1 ? 
ATOM   4693 O O   . GLN B 1 283 ? -6.972  -14.978 6.377  1.00 37.61  ? 306 GLN B O   1 ? 
ATOM   4694 C CB  . GLN B 1 283 ? -4.139  -15.952 5.749  1.00 48.31  ? 306 GLN B CB  1 ? 
ATOM   4695 C CG  . GLN B 1 283 ? -3.278  -15.266 6.798  1.00 58.43  ? 306 GLN B CG  1 ? 
ATOM   4696 C CD  . GLN B 1 283 ? -2.392  -14.194 6.213  1.00 53.94  ? 306 GLN B CD  1 ? 
ATOM   4697 O OE1 . GLN B 1 283 ? -1.191  -14.396 6.020  1.00 44.34  ? 306 GLN B OE1 1 ? 
ATOM   4698 N NE2 . GLN B 1 283 ? -2.980  -13.044 5.921  1.00 53.52  ? 306 GLN B NE2 1 ? 
ATOM   4699 N N   . PRO B 1 284 ? -7.423  -16.601 4.904  1.00 33.38  ? 307 PRO B N   1 ? 
ATOM   4700 C CA  . PRO B 1 284 ? -8.727  -16.027 4.594  1.00 36.12  ? 307 PRO B CA  1 ? 
ATOM   4701 C C   . PRO B 1 284 ? -9.608  -15.764 5.824  1.00 33.46  ? 307 PRO B C   1 ? 
ATOM   4702 O O   . PRO B 1 284 ? -10.467 -14.887 5.767  1.00 33.46  ? 307 PRO B O   1 ? 
ATOM   4703 C CB  . PRO B 1 284 ? -9.303  -17.098 3.676  1.00 31.01  ? 307 PRO B CB  1 ? 
ATOM   4704 C CG  . PRO B 1 284 ? -8.114  -17.564 2.894  1.00 31.62  ? 307 PRO B CG  1 ? 
ATOM   4705 C CD  . PRO B 1 284 ? -7.070  -17.671 3.978  1.00 37.14  ? 307 PRO B CD  1 ? 
ATOM   4706 N N   . VAL B 1 285 ? -9.387  -16.500 6.912  1.00 34.53  ? 308 VAL B N   1 ? 
ATOM   4707 C CA  . VAL B 1 285 ? -10.160 -16.333 8.179  1.00 32.48  ? 308 VAL B CA  1 ? 
ATOM   4708 C C   . VAL B 1 285 ? -10.040 -14.891 8.696  1.00 29.61  ? 308 VAL B C   1 ? 
ATOM   4709 O O   . VAL B 1 285 ? -10.994 -14.398 9.300  1.00 32.46  ? 308 VAL B O   1 ? 
ATOM   4710 C CB  . VAL B 1 285 ? -9.602  -17.369 9.176  1.00 39.02  ? 308 VAL B CB  1 ? 
ATOM   4711 C CG1 . VAL B 1 285 ? -9.778  -16.949 10.630 1.00 53.29  ? 308 VAL B CG1 1 ? 
ATOM   4712 C CG2 . VAL B 1 285 ? -10.205 -18.740 8.933  1.00 49.03  ? 308 VAL B CG2 1 ? 
ATOM   4713 N N   . TRP B 1 286 ? -8.926  -14.226 8.418  1.00 25.45  ? 309 TRP B N   1 ? 
ATOM   4714 C CA  . TRP B 1 286 ? -8.731  -12.875 8.990  1.00 27.54  ? 309 TRP B CA  1 ? 
ATOM   4715 C C   . TRP B 1 286 ? -9.868  -11.969 8.555  1.00 30.05  ? 309 TRP B C   1 ? 
ATOM   4716 O O   . TRP B 1 286 ? -10.251 -11.096 9.334  1.00 34.96  ? 309 TRP B O   1 ? 
ATOM   4717 C CB  . TRP B 1 286 ? -7.396  -12.283 8.534  1.00 26.96  ? 309 TRP B CB  1 ? 
ATOM   4718 C CG  . TRP B 1 286 ? -6.159  -12.943 9.074  1.00 30.96  ? 309 TRP B CG  1 ? 
ATOM   4719 C CD1 . TRP B 1 286 ? -5.998  -14.223 9.515  1.00 27.67  ? 309 TRP B CD1 1 ? 
ATOM   4720 C CD2 . TRP B 1 286 ? -4.870  -12.311 9.190  1.00 24.51  ? 309 TRP B CD2 1 ? 
ATOM   4721 N NE1 . TRP B 1 286 ? -4.703  -14.427 9.906  1.00 26.71  ? 309 TRP B NE1 1 ? 
ATOM   4722 C CE2 . TRP B 1 286 ? -3.989  -13.274 9.719  1.00 29.14  ? 309 TRP B CE2 1 ? 
ATOM   4723 C CE3 . TRP B 1 286 ? -4.385  -11.033 8.902  1.00 30.23  ? 309 TRP B CE3 1 ? 
ATOM   4724 C CZ2 . TRP B 1 286 ? -2.649  -12.994 9.961  1.00 32.39  ? 309 TRP B CZ2 1 ? 
ATOM   4725 C CZ3 . TRP B 1 286 ? -3.060  -10.756 9.144  1.00 35.79  ? 309 TRP B CZ3 1 ? 
ATOM   4726 C CH2 . TRP B 1 286 ? -2.205  -11.728 9.659  1.00 34.63  ? 309 TRP B CH2 1 ? 
ATOM   4727 N N   . GLN B 1 287 ? -10.389 -12.181 7.350  1.00 32.80  ? 310 GLN B N   1 ? 
ATOM   4728 C CA  . GLN B 1 287 ? -11.406 -11.261 6.781  1.00 32.53  ? 310 GLN B CA  1 ? 
ATOM   4729 C C   . GLN B 1 287 ? -12.675 -11.208 7.642  1.00 31.77  ? 310 GLN B C   1 ? 
ATOM   4730 O O   . GLN B 1 287 ? -13.229 -10.110 7.760  1.00 37.04  ? 310 GLN B O   1 ? 
ATOM   4731 C CB  . GLN B 1 287 ? -11.682 -11.673 5.340  1.00 34.51  ? 310 GLN B CB  1 ? 
ATOM   4732 C CG  . GLN B 1 287 ? -10.866 -10.887 4.324  1.00 59.19  ? 310 GLN B CG  1 ? 
ATOM   4733 C CD  . GLN B 1 287 ? -10.923 -9.393  4.544  1.00 68.18  ? 310 GLN B CD  1 ? 
ATOM   4734 O OE1 . GLN B 1 287 ? -9.898  -8.705  4.554  1.00 77.29  ? 310 GLN B OE1 1 ? 
ATOM   4735 N NE2 . GLN B 1 287 ? -12.130 -8.871  4.712  1.00 68.35  ? 310 GLN B NE2 1 ? 
ATOM   4736 N N   . LYS B 1 288 ? -13.074 -12.327 8.233  1.00 26.90  ? 311 LYS B N   1 ? 
ATOM   4737 C CA  . LYS B 1 288 ? -14.255 -12.386 9.124  1.00 31.13  ? 311 LYS B CA  1 ? 
ATOM   4738 C C   . LYS B 1 288 ? -14.046 -11.584 10.414 1.00 32.09  ? 311 LYS B C   1 ? 
ATOM   4739 O O   . LYS B 1 288 ? -15.049 -11.225 11.025 1.00 40.07  ? 311 LYS B O   1 ? 
ATOM   4740 C CB  . LYS B 1 288 ? -14.510 -13.831 9.535  1.00 36.61  ? 311 LYS B CB  1 ? 
ATOM   4741 C CG  . LYS B 1 288 ? -15.537 -14.627 8.759  1.00 48.73  ? 311 LYS B CG  1 ? 
ATOM   4742 C CD  . LYS B 1 288 ? -16.279 -15.576 9.691  1.00 59.12  ? 311 LYS B CD  1 ? 
ATOM   4743 C CE  . LYS B 1 288 ? -16.865 -14.857 10.867 1.00 49.02  ? 311 LYS B CE  1 ? 
ATOM   4744 N NZ  . LYS B 1 288 ? -17.091 -15.745 12.008 1.00 41.65  ? 311 LYS B NZ  1 ? 
ATOM   4745 N N   . PHE B 1 289 ? -12.808 -11.289 10.793 1.00 30.80  ? 312 PHE B N   1 ? 
ATOM   4746 C CA  . PHE B 1 289 ? -12.589 -10.650 12.118 1.00 34.07  ? 312 PHE B CA  1 ? 
ATOM   4747 C C   . PHE B 1 289 ? -11.918 -9.289  11.972 1.00 35.61  ? 312 PHE B C   1 ? 
ATOM   4748 O O   . PHE B 1 289 ? -11.885 -8.537  12.961 1.00 32.56  ? 312 PHE B O   1 ? 
ATOM   4749 C CB  . PHE B 1 289 ? -11.830 -11.670 12.978 1.00 26.94  ? 312 PHE B CB  1 ? 
ATOM   4750 C CG  . PHE B 1 289 ? -12.524 -13.017 13.108 1.00 26.42  ? 312 PHE B CG  1 ? 
ATOM   4751 C CD1 . PHE B 1 289 ? -13.628 -13.173 13.934 1.00 22.81  ? 312 PHE B CD1 1 ? 
ATOM   4752 C CD2 . PHE B 1 289 ? -12.081 -14.120 12.391 1.00 25.01  ? 312 PHE B CD2 1 ? 
ATOM   4753 C CE1 . PHE B 1 289 ? -14.263 -14.396 14.043 1.00 24.25  ? 312 PHE B CE1 1 ? 
ATOM   4754 C CE2 . PHE B 1 289 ? -12.722 -15.339 12.504 1.00 28.31  ? 312 PHE B CE2 1 ? 
ATOM   4755 C CZ  . PHE B 1 289 ? -13.809 -15.474 13.329 1.00 25.85  ? 312 PHE B CZ  1 ? 
ATOM   4756 N N   . ARG B 1 290 ? -11.437 -8.967  10.775 1.00 32.02  ? 313 ARG B N   1 ? 
ATOM   4757 C CA  . ARG B 1 290 ? -10.740 -7.674  10.531 1.00 36.96  ? 313 ARG B CA  1 ? 
ATOM   4758 C C   . ARG B 1 290 ? -11.512 -6.483  11.129 1.00 34.16  ? 313 ARG B C   1 ? 
ATOM   4759 O O   . ARG B 1 290 ? -10.874 -5.612  11.733 1.00 35.16  ? 313 ARG B O   1 ? 
ATOM   4760 C CB  . ARG B 1 290 ? -10.525 -7.531  9.022  1.00 37.72  ? 313 ARG B CB  1 ? 
ATOM   4761 C CG  . ARG B 1 290 ? -9.113  -7.817  8.546  1.00 44.49  ? 313 ARG B CG  1 ? 
ATOM   4762 C CD  . ARG B 1 290 ? -8.916  -7.260  7.151  1.00 40.35  ? 313 ARG B CD  1 ? 
ATOM   4763 N NE  . ARG B 1 290 ? -7.493  -7.112  6.836  1.00 54.31  ? 313 ARG B NE  1 ? 
ATOM   4764 C CZ  . ARG B 1 290 ? -6.681  -8.103  6.499  1.00 58.90  ? 313 ARG B CZ  1 ? 
ATOM   4765 N NH1 . ARG B 1 290 ? -7.171  -9.278  6.149  1.00 58.10  ? 313 ARG B NH1 1 ? 
ATOM   4766 N NH2 . ARG B 1 290 ? -5.376  -7.906  6.502  1.00 56.09  ? 313 ARG B NH2 1 ? 
ATOM   4767 N N   . GLY B 1 291 ? -12.836 -6.462  10.983 1.00 41.26  ? 314 GLY B N   1 ? 
ATOM   4768 C CA  . GLY B 1 291 ? -13.662 -5.354  11.505 1.00 39.79  ? 314 GLY B CA  1 ? 
ATOM   4769 C C   . GLY B 1 291 ? -13.754 -5.353  13.018 1.00 46.82  ? 314 GLY B C   1 ? 
ATOM   4770 O O   . GLY B 1 291 ? -13.732 -4.262  13.608 1.00 41.13  ? 314 GLY B O   1 ? 
ATOM   4771 N N   . ASN B 1 292 ? -13.915 -6.522  13.623 1.00 37.80  ? 315 ASN B N   1 ? 
ATOM   4772 C CA  . ASN B 1 292 ? -13.969 -6.656  15.098 1.00 36.83  ? 315 ASN B CA  1 ? 
ATOM   4773 C C   . ASN B 1 292 ? -12.689 -6.147  15.762 1.00 31.81  ? 315 ASN B C   1 ? 
ATOM   4774 O O   . ASN B 1 292 ? -12.790 -5.467  16.784 1.00 33.52  ? 315 ASN B O   1 ? 
ATOM   4775 C CB  . ASN B 1 292 ? -14.082 -8.125  15.479 1.00 45.49  ? 315 ASN B CB  1 ? 
ATOM   4776 C CG  . ASN B 1 292 ? -15.488 -8.588  15.762 1.00 47.28  ? 315 ASN B CG  1 ? 
ATOM   4777 O OD1 . ASN B 1 292 ? -16.393 -7.769  15.945 1.00 49.27  ? 315 ASN B OD1 1 ? 
ATOM   4778 N ND2 . ASN B 1 292 ? -15.680 -9.898  15.818 1.00 37.47  ? 315 ASN B ND2 1 ? 
ATOM   4779 N N   . VAL B 1 293 ? -11.529 -6.508  15.225 1.00 27.95  ? 316 VAL B N   1 ? 
ATOM   4780 C CA  . VAL B 1 293 ? -10.253 -6.158  15.908 1.00 29.48  ? 316 VAL B CA  1 ? 
ATOM   4781 C C   . VAL B 1 293 ? -9.878  -4.706  15.591 1.00 40.61  ? 316 VAL B C   1 ? 
ATOM   4782 O O   . VAL B 1 293 ? -9.327  -4.041  16.480 1.00 50.19  ? 316 VAL B O   1 ? 
ATOM   4783 C CB  . VAL B 1 293 ? -9.107  -7.127  15.560 1.00 30.21  ? 316 VAL B CB  1 ? 
ATOM   4784 C CG1 . VAL B 1 293 ? -9.489  -8.571  15.863 1.00 27.06  ? 316 VAL B CG1 1 ? 
ATOM   4785 C CG2 . VAL B 1 293 ? -8.628  -6.993  14.123 1.00 29.10  ? 316 VAL B CG2 1 ? 
ATOM   4786 N N   . GLY B 1 294 ? -10.179 -4.235  14.390 1.00 40.64  ? 317 GLY B N   1 ? 
ATOM   4787 C CA  . GLY B 1 294 ? -9.741  -2.876  14.022 1.00 35.83  ? 317 GLY B CA  1 ? 
ATOM   4788 C C   . GLY B 1 294 ? -8.445  -2.889  13.250 1.00 31.99  ? 317 GLY B C   1 ? 
ATOM   4789 O O   . GLY B 1 294 ? -7.622  -3.776  13.495 1.00 41.50  ? 317 GLY B O   1 ? 
ATOM   4790 N N   . ALA B 1 295 ? -8.260  -1.915  12.366 1.00 37.95  ? 318 ALA B N   1 ? 
ATOM   4791 C CA  . ALA B 1 295 ? -7.061  -1.886  11.496 1.00 38.01  ? 318 ALA B CA  1 ? 
ATOM   4792 C C   . ALA B 1 295 ? -5.817  -1.400  12.247 1.00 34.46  ? 318 ALA B C   1 ? 
ATOM   4793 O O   . ALA B 1 295 ? -4.731  -1.913  12.009 1.00 37.52  ? 318 ALA B O   1 ? 
ATOM   4794 C CB  . ALA B 1 295 ? -7.348  -1.047  10.278 1.00 29.85  ? 318 ALA B CB  1 ? 
ATOM   4795 N N   . ASP B 1 296 ? -5.990  -0.435  13.138 1.00 32.39  ? 319 ASP B N   1 ? 
ATOM   4796 C CA  . ASP B 1 296 ? -4.834  0.081   13.911 1.00 37.80  ? 319 ASP B CA  1 ? 
ATOM   4797 C C   . ASP B 1 296 ? -4.280  -1.010  14.836 1.00 39.04  ? 319 ASP B C   1 ? 
ATOM   4798 O O   . ASP B 1 296 ? -3.057  -1.128  14.916 1.00 37.11  ? 319 ASP B O   1 ? 
ATOM   4799 C CB  . ASP B 1 296 ? -5.179  1.399   14.579 1.00 45.59  ? 319 ASP B CB  1 ? 
ATOM   4800 C CG  . ASP B 1 296 ? -5.641  2.458   13.589 1.00 71.97  ? 319 ASP B CG  1 ? 
ATOM   4801 O OD1 . ASP B 1 296 ? -6.816  2.397   13.172 1.00 87.74  ? 319 ASP B OD1 1 ? 
ATOM   4802 O OD2 . ASP B 1 296 ? -4.809  3.303   13.205 1.00 75.13  ? 319 ASP B OD2 1 ? 
ATOM   4803 N N   . LEU B 1 297 ? -5.146  -1.820  15.451 1.00 36.98  ? 320 LEU B N   1 ? 
ATOM   4804 C CA  . LEU B 1 297 ? -4.645  -2.944  16.292 1.00 34.50  ? 320 LEU B CA  1 ? 
ATOM   4805 C C   . LEU B 1 297 ? -3.931  -3.970  15.401 1.00 32.58  ? 320 LEU B C   1 ? 
ATOM   4806 O O   . LEU B 1 297 ? -2.843  -4.417  15.777 1.00 32.30  ? 320 LEU B O   1 ? 
ATOM   4807 C CB  . LEU B 1 297 ? -5.765  -3.601  17.098 1.00 30.68  ? 320 LEU B CB  1 ? 
ATOM   4808 C CG  . LEU B 1 297 ? -5.345  -4.413  18.323 1.00 31.02  ? 320 LEU B CG  1 ? 
ATOM   4809 C CD1 . LEU B 1 297 ? -4.682  -3.519  19.347 1.00 29.55  ? 320 LEU B CD1 1 ? 
ATOM   4810 C CD2 . LEU B 1 297 ? -6.575  -5.084  18.903 1.00 30.18  ? 320 LEU B CD2 1 ? 
ATOM   4811 N N   . LEU B 1 298 ? -4.543  -4.320  14.270 1.00 30.37  ? 321 LEU B N   1 ? 
ATOM   4812 C CA  . LEU B 1 298 ? -3.940  -5.321  13.353 1.00 31.65  ? 321 LEU B CA  1 ? 
ATOM   4813 C C   . LEU B 1 298 ? -2.595  -4.796  12.824 1.00 32.31  ? 321 LEU B C   1 ? 
ATOM   4814 O O   . LEU B 1 298 ? -1.622  -5.547  12.858 1.00 35.09  ? 321 LEU B O   1 ? 
ATOM   4815 C CB  . LEU B 1 298 ? -4.910  -5.674  12.227 1.00 32.94  ? 321 LEU B CB  1 ? 
ATOM   4816 C CG  . LEU B 1 298 ? -4.503  -6.859  11.351 1.00 33.79  ? 321 LEU B CG  1 ? 
ATOM   4817 C CD1 . LEU B 1 298 ? -4.403  -8.135  12.161 1.00 35.28  ? 321 LEU B CD1 1 ? 
ATOM   4818 C CD2 . LEU B 1 298 ? -5.452  -7.023  10.184 1.00 40.38  ? 321 LEU B CD2 1 ? 
ATOM   4819 N N   . GLN B 1 299 ? -2.549  -3.538  12.386 1.00 33.56  ? 322 GLN B N   1 ? 
ATOM   4820 C CA  . GLN B 1 299 ? -1.277  -2.933  11.912 1.00 32.53  ? 322 GLN B CA  1 ? 
ATOM   4821 C C   . GLN B 1 299 ? -0.214  -3.043  13.011 1.00 28.26  ? 322 GLN B C   1 ? 
ATOM   4822 O O   . GLN B 1 299 ? 0.896   -3.487  12.722 1.00 31.79  ? 322 GLN B O   1 ? 
ATOM   4823 C CB  . GLN B 1 299 ? -1.466  -1.477  11.496 1.00 31.47  ? 322 GLN B CB  1 ? 
ATOM   4824 C CG  . GLN B 1 299 ? -0.169  -0.698  11.333 1.00 51.40  ? 322 GLN B CG  1 ? 
ATOM   4825 C CD  . GLN B 1 299 ? -0.371  0.647   10.671 1.00 73.16  ? 322 GLN B CD  1 ? 
ATOM   4826 O OE1 . GLN B 1 299 ? -1.489  1.025   10.306 1.00 70.82  ? 322 GLN B OE1 1 ? 
ATOM   4827 N NE2 . GLN B 1 299 ? 0.717   1.385   10.512 1.00 70.88  ? 322 GLN B NE2 1 ? 
ATOM   4828 N N   . ALA B 1 300 ? -0.571  -2.672  14.233 1.00 30.85  ? 323 ALA B N   1 ? 
ATOM   4829 C CA  . ALA B 1 300 ? 0.377   -2.799  15.365 1.00 31.14  ? 323 ALA B CA  1 ? 
ATOM   4830 C C   . ALA B 1 300 ? 0.894   -4.235  15.481 1.00 34.63  ? 323 ALA B C   1 ? 
ATOM   4831 O O   . ALA B 1 300 ? 2.092   -4.425  15.717 1.00 28.86  ? 323 ALA B O   1 ? 
ATOM   4832 C CB  . ALA B 1 300 ? -0.288  -2.363  16.638 1.00 32.07  ? 323 ALA B CB  1 ? 
ATOM   4833 N N   . ALA B 1 301 ? -0.006  -5.209  15.346 1.00 29.17  ? 324 ALA B N   1 ? 
ATOM   4834 C CA  . ALA B 1 301 ? 0.391   -6.626  15.487 1.00 26.40  ? 324 ALA B CA  1 ? 
ATOM   4835 C C   . ALA B 1 301 ? 1.349   -7.002  14.361 1.00 28.34  ? 324 ALA B C   1 ? 
ATOM   4836 O O   . ALA B 1 301 ? 2.360   -7.670  14.588 1.00 29.17  ? 324 ALA B O   1 ? 
ATOM   4837 C CB  . ALA B 1 301 ? -0.835  -7.490  15.492 1.00 21.69  ? 324 ALA B CB  1 ? 
ATOM   4838 N N   . GLU B 1 302 ? 1.012   -6.567  13.150 1.00 33.89  ? 325 GLU B N   1 ? 
ATOM   4839 C CA  . GLU B 1 302 ? 1.870   -6.903  11.987 1.00 36.63  ? 325 GLU B CA  1 ? 
ATOM   4840 C C   . GLU B 1 302 ? 3.240   -6.222  12.170 1.00 32.44  ? 325 GLU B C   1 ? 
ATOM   4841 O O   . GLU B 1 302 ? 4.247   -6.910  11.999 1.00 40.44  ? 325 GLU B O   1 ? 
ATOM   4842 C CB  . GLU B 1 302 ? 1.157   -6.598  10.666 1.00 32.27  ? 325 GLU B CB  1 ? 
ATOM   4843 C CG  . GLU B 1 302 ? -0.222  -7.237  10.551 1.00 37.42  ? 325 GLU B CG  1 ? 
ATOM   4844 C CD  . GLU B 1 302 ? -0.601  -7.755  9.176  1.00 55.93  ? 325 GLU B CD  1 ? 
ATOM   4845 O OE1 . GLU B 1 302 ? 0.066   -8.695  8.698  1.00 61.96  ? 325 GLU B OE1 1 ? 
ATOM   4846 O OE2 . GLU B 1 302 ? -1.569  -7.229  8.590  1.00 46.80  ? 325 GLU B OE2 1 ? 
ATOM   4847 N N   . ALA B 1 303 ? 3.266   -4.955  12.578 1.00 30.06  ? 326 ALA B N   1 ? 
ATOM   4848 C CA  . ALA B 1 303 ? 4.541   -4.230  12.809 1.00 29.68  ? 326 ALA B CA  1 ? 
ATOM   4849 C C   . ALA B 1 303 ? 5.423   -4.932  13.845 1.00 38.62  ? 326 ALA B C   1 ? 
ATOM   4850 O O   . ALA B 1 303 ? 6.631   -4.662  13.857 1.00 33.52  ? 326 ALA B O   1 ? 
ATOM   4851 C CB  . ALA B 1 303 ? 4.246   -2.821  13.241 1.00 28.23  ? 326 ALA B CB  1 ? 
ATOM   4852 N N   . SER B 1 304 ? 4.835   -5.776  14.697 1.00 35.26  ? 327 SER B N   1 ? 
ATOM   4853 C CA  . SER B 1 304 ? 5.574   -6.460  15.788 1.00 35.09  ? 327 SER B CA  1 ? 
ATOM   4854 C C   . SER B 1 304 ? 6.509   -7.534  15.228 1.00 31.74  ? 327 SER B C   1 ? 
ATOM   4855 O O   . SER B 1 304 ? 7.350   -8.037  15.966 1.00 32.74  ? 327 SER B O   1 ? 
ATOM   4856 C CB  . SER B 1 304 ? 4.600   -7.053  16.773 1.00 36.31  ? 327 SER B CB  1 ? 
ATOM   4857 O OG  . SER B 1 304 ? 4.087   -8.296  16.324 1.00 36.54  ? 327 SER B OG  1 ? 
ATOM   4858 N N   . ASN B 1 305 ? 6.320   -7.880  13.969 1.00 30.77  ? 328 ASN B N   1 ? 
ATOM   4859 C CA  . ASN B 1 305 ? 7.153   -8.934  13.348 1.00 34.36  ? 328 ASN B CA  1 ? 
ATOM   4860 C C   . ASN B 1 305 ? 8.499   -8.309  12.977 1.00 35.79  ? 328 ASN B C   1 ? 
ATOM   4861 O O   . ASN B 1 305 ? 9.477   -9.048  12.882 1.00 43.90  ? 328 ASN B O   1 ? 
ATOM   4862 C CB  . ASN B 1 305 ? 6.389   -9.565  12.199 1.00 35.41  ? 328 ASN B CB  1 ? 
ATOM   4863 C CG  . ASN B 1 305 ? 5.309   -10.492 12.703 1.00 36.64  ? 328 ASN B CG  1 ? 
ATOM   4864 O OD1 . ASN B 1 305 ? 5.596   -11.428 13.455 1.00 28.29  ? 328 ASN B OD1 1 ? 
ATOM   4865 N ND2 . ASN B 1 305 ? 4.069   -10.240 12.316 1.00 25.40  ? 328 ASN B ND2 1 ? 
ATOM   4866 N N   . ARG B 1 306 ? 8.537   -6.988  12.846 1.00 47.15  ? 329 ARG B N   1 ? 
ATOM   4867 C CA  . ARG B 1 306 ? 9.798   -6.263  12.562 1.00 56.17  ? 329 ARG B CA  1 ? 
ATOM   4868 C C   . ARG B 1 306 ? 10.683  -6.261  13.814 1.00 56.66  ? 329 ARG B C   1 ? 
ATOM   4869 O O   . ARG B 1 306 ? 10.296  -5.645  14.816 1.00 50.89  ? 329 ARG B O   1 ? 
ATOM   4870 C CB  . ARG B 1 306 ? 9.456   -4.834  12.131 1.00 65.86  ? 329 ARG B CB  1 ? 
ATOM   4871 C CG  . ARG B 1 306 ? 10.619  -3.906  11.805 1.00 73.87  ? 329 ARG B CG  1 ? 
ATOM   4872 C CD  . ARG B 1 306 ? 10.211  -2.442  11.640 1.00 76.44  ? 329 ARG B CD  1 ? 
ATOM   4873 N NE  . ARG B 1 306 ? 9.268   -2.196  10.542 1.00 100.07 ? 329 ARG B NE  1 ? 
ATOM   4874 C CZ  . ARG B 1 306 ? 7.986   -1.886  10.702 1.00 97.12  ? 329 ARG B CZ  1 ? 
ATOM   4875 N NH1 . ARG B 1 306 ? 7.627   -1.023  11.634 1.00 77.05  ? 329 ARG B NH1 1 ? 
ATOM   4876 N NH2 . ARG B 1 306 ? 7.067   -2.450  9.938  1.00 85.84  ? 329 ARG B NH2 1 ? 
ATOM   4877 N N   . PRO B 1 307 ? 11.852  -6.929  13.791 1.00 59.63  ? 330 PRO B N   1 ? 
ATOM   4878 C CA  . PRO B 1 307 ? 12.761  -6.910  14.925 1.00 51.71  ? 330 PRO B CA  1 ? 
ATOM   4879 C C   . PRO B 1 307 ? 13.405  -5.540  15.102 1.00 46.31  ? 330 PRO B C   1 ? 
ATOM   4880 O O   . PRO B 1 307 ? 13.332  -5.083  16.250 1.00 52.98  ? 330 PRO B O   1 ? 
ATOM   4881 C CB  . PRO B 1 307 ? 13.773  -7.994  14.581 1.00 51.53  ? 330 PRO B CB  1 ? 
ATOM   4882 C CG  . PRO B 1 307 ? 13.119  -8.776  13.466 1.00 54.08  ? 330 PRO B CG  1 ? 
ATOM   4883 C CD  . PRO B 1 307 ? 12.331  -7.737  12.694 1.00 55.73  ? 330 PRO B CD  1 ? 
HETATM 4884 C C1  . SIN C 2 .   ? 9.566   13.817  21.042 1.00 17.85  ? 401 SIN A C1  1 ? 
HETATM 4885 O O1  . SIN C 2 .   ? 8.378   13.377  21.320 1.00 19.28  ? 401 SIN A O1  1 ? 
HETATM 4886 O O2  . SIN C 2 .   ? 10.014  14.169  19.844 1.00 17.25  ? 401 SIN A O2  1 ? 
HETATM 4887 C C2  . SIN C 2 .   ? 10.548  13.951  22.198 1.00 15.23  ? 401 SIN A C2  1 ? 
HETATM 4888 C C3  . SIN C 2 .   ? 10.745  12.568  22.881 1.00 12.88  ? 401 SIN A C3  1 ? 
HETATM 4889 C C4  . SIN C 2 .   ? 11.760  12.661  24.017 1.00 15.39  ? 401 SIN A C4  1 ? 
HETATM 4890 O O3  . SIN C 2 .   ? 11.317  12.536  25.248 1.00 15.63  ? 401 SIN A O3  1 ? 
HETATM 4891 O O4  . SIN C 2 .   ? 12.998  12.905  23.691 1.00 19.50  ? 401 SIN A O4  1 ? 
HETATM 4892 C C1  . SIN D 2 .   ? -6.271  -24.625 25.852 1.00 18.11  ? 401 SIN B C1  1 ? 
HETATM 4893 O O1  . SIN D 2 .   ? -7.414  -24.736 26.303 1.00 16.25  ? 401 SIN B O1  1 ? 
HETATM 4894 O O2  . SIN D 2 .   ? -5.818  -25.339 24.909 1.00 18.49  ? 401 SIN B O2  1 ? 
HETATM 4895 C C2  . SIN D 2 .   ? -5.326  -23.650 26.564 1.00 17.68  ? 401 SIN B C2  1 ? 
HETATM 4896 C C3  . SIN D 2 .   ? -4.928  -24.211 27.968 1.00 15.56  ? 401 SIN B C3  1 ? 
HETATM 4897 C C4  . SIN D 2 .   ? -3.987  -23.294 28.740 1.00 16.96  ? 401 SIN B C4  1 ? 
HETATM 4898 O O3  . SIN D 2 .   ? -2.750  -23.353 28.440 1.00 16.31  ? 401 SIN B O3  1 ? 
HETATM 4899 O O4  . SIN D 2 .   ? -4.466  -22.562 29.643 1.00 15.14  ? 401 SIN B O4  1 ? 
HETATM 4900 O O   . HOH E 3 .   ? 14.591  -2.196  49.837 1.00 30.28  ? 501 HOH A O   1 ? 
HETATM 4901 O O   . HOH E 3 .   ? 26.200  17.168  20.354 1.00 24.28  ? 502 HOH A O   1 ? 
HETATM 4902 O O   . HOH E 3 .   ? 17.466  18.122  3.755  1.00 30.94  ? 503 HOH A O   1 ? 
HETATM 4903 O O   . HOH E 3 .   ? 21.257  8.240   21.392 1.00 21.08  ? 504 HOH A O   1 ? 
HETATM 4904 O O   . HOH E 3 .   ? -0.748  10.198  18.616 1.00 30.30  ? 505 HOH A O   1 ? 
HETATM 4905 O O   . HOH E 3 .   ? 20.260  20.908  33.914 1.00 20.88  ? 506 HOH A O   1 ? 
HETATM 4906 O O   . HOH E 3 .   ? -3.970  18.608  38.423 1.00 23.27  ? 507 HOH A O   1 ? 
HETATM 4907 O O   . HOH E 3 .   ? 25.575  14.978  45.861 1.00 27.51  ? 508 HOH A O   1 ? 
HETATM 4908 O O   . HOH E 3 .   ? 0.984   5.270   20.803 1.00 29.42  ? 509 HOH A O   1 ? 
HETATM 4909 O O   . HOH E 3 .   ? 2.795   16.298  1.844  1.00 23.89  ? 510 HOH A O   1 ? 
HETATM 4910 O O   . HOH E 3 .   ? 8.381   5.709   22.550 1.00 21.86  ? 511 HOH A O   1 ? 
HETATM 4911 O O   . HOH E 3 .   ? 7.047   3.931   29.673 1.00 13.67  ? 512 HOH A O   1 ? 
HETATM 4912 O O   . HOH E 3 .   ? 15.573  1.266   31.021 1.00 19.49  ? 513 HOH A O   1 ? 
HETATM 4913 O O   . HOH E 3 .   ? 8.329   -0.180  54.134 1.00 54.70  ? 514 HOH A O   1 ? 
HETATM 4914 O O   . HOH E 3 .   ? 2.167   1.869   37.255 1.00 25.03  ? 515 HOH A O   1 ? 
HETATM 4915 O O   . HOH E 3 .   ? 22.279  7.071   19.091 1.00 24.55  ? 516 HOH A O   1 ? 
HETATM 4916 O O   . HOH E 3 .   ? 20.623  28.654  38.799 1.00 32.58  ? 517 HOH A O   1 ? 
HETATM 4917 O O   . HOH E 3 .   ? 12.605  26.189  41.226 1.00 30.67  ? 518 HOH A O   1 ? 
HETATM 4918 O O   . HOH E 3 .   ? 17.220  34.765  19.749 1.00 26.75  ? 519 HOH A O   1 ? 
HETATM 4919 O O   . HOH E 3 .   ? 24.270  23.077  33.936 1.00 29.88  ? 520 HOH A O   1 ? 
HETATM 4920 O O   . HOH E 3 .   ? -0.901  27.833  23.417 1.00 40.08  ? 521 HOH A O   1 ? 
HETATM 4921 O O   . HOH E 3 .   ? 24.353  16.391  44.602 1.00 31.77  ? 522 HOH A O   1 ? 
HETATM 4922 O O   . HOH E 3 .   ? 7.526   -3.501  37.579 1.00 28.00  ? 523 HOH A O   1 ? 
HETATM 4923 O O   . HOH E 3 .   ? 24.183  18.833  26.886 1.00 24.68  ? 524 HOH A O   1 ? 
HETATM 4924 O O   . HOH E 3 .   ? 17.099  10.950  22.800 1.00 15.46  ? 525 HOH A O   1 ? 
HETATM 4925 O O   . HOH E 3 .   ? 11.242  3.534   16.667 1.00 36.77  ? 526 HOH A O   1 ? 
HETATM 4926 O O   . HOH E 3 .   ? 2.374   21.145  25.193 1.00 14.94  ? 527 HOH A O   1 ? 
HETATM 4927 O O   . HOH E 3 .   ? 14.197  31.459  40.877 1.00 33.12  ? 528 HOH A O   1 ? 
HETATM 4928 O O   . HOH E 3 .   ? 11.256  22.800  23.421 1.00 24.87  ? 529 HOH A O   1 ? 
HETATM 4929 O O   . HOH E 3 .   ? 7.795   27.447  3.300  1.00 22.94  ? 530 HOH A O   1 ? 
HETATM 4930 O O   . HOH E 3 .   ? 13.032  33.797  4.683  1.00 35.85  ? 531 HOH A O   1 ? 
HETATM 4931 O O   . HOH E 3 .   ? 9.660   7.193   3.921  1.00 36.51  ? 532 HOH A O   1 ? 
HETATM 4932 O O   . HOH E 3 .   ? 7.258   11.922  27.216 1.00 14.11  ? 533 HOH A O   1 ? 
HETATM 4933 O O   . HOH E 3 .   ? 19.706  5.947   6.763  1.00 31.18  ? 534 HOH A O   1 ? 
HETATM 4934 O O   . HOH E 3 .   ? 16.961  35.811  10.402 1.00 31.73  ? 535 HOH A O   1 ? 
HETATM 4935 O O   . HOH E 3 .   ? 4.935   23.086  26.972 1.00 16.52  ? 536 HOH A O   1 ? 
HETATM 4936 O O   . HOH E 3 .   ? 19.737  16.346  3.393  1.00 25.02  ? 537 HOH A O   1 ? 
HETATM 4937 O O   . HOH E 3 .   ? 8.744   10.660  31.056 1.00 13.57  ? 538 HOH A O   1 ? 
HETATM 4938 O O   . HOH E 3 .   ? 13.129  26.357  20.819 1.00 24.01  ? 539 HOH A O   1 ? 
HETATM 4939 O O   . HOH E 3 .   ? 9.538   -1.684  30.659 1.00 34.28  ? 540 HOH A O   1 ? 
HETATM 4940 O O   . HOH E 3 .   ? 20.091  23.667  32.895 1.00 25.34  ? 541 HOH A O   1 ? 
HETATM 4941 O O   . HOH E 3 .   ? 15.803  3.999   30.608 1.00 12.58  ? 542 HOH A O   1 ? 
HETATM 4942 O O   . HOH E 3 .   ? 23.646  20.720  17.201 1.00 32.24  ? 543 HOH A O   1 ? 
HETATM 4943 O O   . HOH E 3 .   ? 18.991  -3.033  29.026 1.00 31.82  ? 544 HOH A O   1 ? 
HETATM 4944 O O   . HOH E 3 .   ? 10.446  16.540  18.010 1.00 19.76  ? 545 HOH A O   1 ? 
HETATM 4945 O O   . HOH E 3 .   ? 27.089  5.666   44.757 1.00 19.57  ? 546 HOH A O   1 ? 
HETATM 4946 O O   . HOH E 3 .   ? 6.335   7.845   30.237 1.00 15.38  ? 547 HOH A O   1 ? 
HETATM 4947 O O   . HOH E 3 .   ? 0.507   0.755   31.251 1.00 31.80  ? 548 HOH A O   1 ? 
HETATM 4948 O O   . HOH E 3 .   ? 5.734   22.750  38.530 1.00 22.37  ? 549 HOH A O   1 ? 
HETATM 4949 O O   . HOH E 3 .   ? 26.925  1.203   47.813 1.00 20.77  ? 550 HOH A O   1 ? 
HETATM 4950 O O   . HOH E 3 .   ? 27.632  18.706  27.907 1.00 28.84  ? 551 HOH A O   1 ? 
HETATM 4951 O O   . HOH E 3 .   ? 4.795   24.185  24.208 1.00 25.36  ? 552 HOH A O   1 ? 
HETATM 4952 O O   . HOH E 3 .   ? 8.169   18.288  17.669 1.00 18.84  ? 553 HOH A O   1 ? 
HETATM 4953 O O   . HOH E 3 .   ? 5.264   4.379   45.440 1.00 32.70  ? 554 HOH A O   1 ? 
HETATM 4954 O O   . HOH E 3 .   ? 25.582  30.325  23.548 1.00 26.21  ? 555 HOH A O   1 ? 
HETATM 4955 O O   . HOH E 3 .   ? 2.061   15.885  28.400 1.00 20.21  ? 556 HOH A O   1 ? 
HETATM 4956 O O   . HOH E 3 .   ? 3.625   13.629  27.698 1.00 16.24  ? 557 HOH A O   1 ? 
HETATM 4957 O O   . HOH E 3 .   ? -2.188  13.789  14.455 1.00 25.01  ? 558 HOH A O   1 ? 
HETATM 4958 O O   . HOH E 3 .   ? 6.105   3.832   15.264 1.00 21.04  ? 559 HOH A O   1 ? 
HETATM 4959 O O   . HOH E 3 .   ? 26.995  -0.104  36.554 1.00 37.10  ? 560 HOH A O   1 ? 
HETATM 4960 O O   . HOH E 3 .   ? 7.333   37.128  30.854 1.00 29.02  ? 561 HOH A O   1 ? 
HETATM 4961 O O   . HOH E 3 .   ? 0.645   4.935   27.047 1.00 22.60  ? 562 HOH A O   1 ? 
HETATM 4962 O O   . HOH E 3 .   ? 17.280  27.459  17.858 1.00 15.82  ? 563 HOH A O   1 ? 
HETATM 4963 O O   . HOH E 3 .   ? 0.641   32.360  30.274 1.00 29.32  ? 564 HOH A O   1 ? 
HETATM 4964 O O   . HOH E 3 .   ? 18.028  2.060   20.363 1.00 26.84  ? 565 HOH A O   1 ? 
HETATM 4965 O O   . HOH E 3 .   ? 23.006  4.986   32.997 1.00 21.13  ? 566 HOH A O   1 ? 
HETATM 4966 O O   . HOH E 3 .   ? -4.576  23.174  21.440 1.00 41.70  ? 567 HOH A O   1 ? 
HETATM 4967 O O   . HOH E 3 .   ? 20.603  17.076  17.409 1.00 13.52  ? 568 HOH A O   1 ? 
HETATM 4968 O O   . HOH E 3 .   ? 0.833   36.990  21.758 1.00 31.54  ? 569 HOH A O   1 ? 
HETATM 4969 O O   . HOH E 3 .   ? 11.852  3.473   53.456 1.00 36.81  ? 570 HOH A O   1 ? 
HETATM 4970 O O   . HOH E 3 .   ? 0.481   18.510  25.062 1.00 32.57  ? 571 HOH A O   1 ? 
HETATM 4971 O O   . HOH E 3 .   ? 15.698  -0.283  43.254 1.00 22.09  ? 572 HOH A O   1 ? 
HETATM 4972 O O   . HOH E 3 .   ? 18.103  2.106   48.329 1.00 27.42  ? 573 HOH A O   1 ? 
HETATM 4973 O O   . HOH E 3 .   ? 3.985   25.447  28.286 1.00 15.26  ? 574 HOH A O   1 ? 
HETATM 4974 O O   . HOH E 3 .   ? 0.308   19.515  27.815 1.00 17.76  ? 575 HOH A O   1 ? 
HETATM 4975 O O   . HOH E 3 .   ? 22.873  19.374  38.656 1.00 25.09  ? 576 HOH A O   1 ? 
HETATM 4976 O O   . HOH E 3 .   ? 19.487  13.599  53.675 1.00 32.72  ? 577 HOH A O   1 ? 
HETATM 4977 O O   . HOH E 3 .   ? 14.685  7.564   21.665 1.00 17.90  ? 578 HOH A O   1 ? 
HETATM 4978 O O   . HOH E 3 .   ? 24.466  12.940  50.472 1.00 27.75  ? 579 HOH A O   1 ? 
HETATM 4979 O O   . HOH E 3 .   ? 23.371  18.133  24.256 1.00 23.20  ? 580 HOH A O   1 ? 
HETATM 4980 O O   . HOH E 3 .   ? 8.902   13.752  26.054 1.00 15.10  ? 581 HOH A O   1 ? 
HETATM 4981 O O   . HOH E 3 .   ? -0.537  15.478  29.261 1.00 22.76  ? 582 HOH A O   1 ? 
HETATM 4982 O O   . HOH E 3 .   ? 13.435  18.098  46.044 1.00 27.09  ? 583 HOH A O   1 ? 
HETATM 4983 O O   . HOH E 3 .   ? 23.202  25.140  17.822 1.00 26.99  ? 584 HOH A O   1 ? 
HETATM 4984 O O   . HOH E 3 .   ? 4.963   9.996   49.846 1.00 30.16  ? 585 HOH A O   1 ? 
HETATM 4985 O O   . HOH E 3 .   ? 2.433   7.664   44.027 1.00 32.26  ? 586 HOH A O   1 ? 
HETATM 4986 O O   . HOH E 3 .   ? 16.821  11.334  25.608 1.00 14.93  ? 587 HOH A O   1 ? 
HETATM 4987 O O   . HOH E 3 .   ? 22.188  3.620   12.880 1.00 32.62  ? 588 HOH A O   1 ? 
HETATM 4988 O O   . HOH E 3 .   ? 19.683  18.923  39.172 1.00 45.29  ? 589 HOH A O   1 ? 
HETATM 4989 O O   . HOH E 3 .   ? 9.984   13.283  15.548 1.00 14.27  ? 590 HOH A O   1 ? 
HETATM 4990 O O   . HOH E 3 .   ? 28.964  13.726  14.485 1.00 25.43  ? 591 HOH A O   1 ? 
HETATM 4991 O O   . HOH E 3 .   ? 18.861  18.138  48.674 1.00 34.57  ? 592 HOH A O   1 ? 
HETATM 4992 O O   . HOH E 3 .   ? 24.893  32.206  21.769 1.00 27.96  ? 593 HOH A O   1 ? 
HETATM 4993 O O   . HOH E 3 .   ? 0.457   8.032   24.052 1.00 22.76  ? 594 HOH A O   1 ? 
HETATM 4994 O O   . HOH E 3 .   ? 15.835  0.975   24.284 1.00 23.14  ? 595 HOH A O   1 ? 
HETATM 4995 O O   . HOH E 3 .   ? 9.342   10.689  28.389 1.00 16.40  ? 596 HOH A O   1 ? 
HETATM 4996 O O   . HOH E 3 .   ? 11.918  20.538  24.680 1.00 17.54  ? 597 HOH A O   1 ? 
HETATM 4997 O O   . HOH E 3 .   ? -5.284  7.363   42.656 1.00 19.07  ? 598 HOH A O   1 ? 
HETATM 4998 O O   . HOH E 3 .   ? 29.904  9.261   10.014 1.00 23.19  ? 599 HOH A O   1 ? 
HETATM 4999 O O   . HOH E 3 .   ? 17.236  36.523  33.869 1.00 35.39  ? 600 HOH A O   1 ? 
HETATM 5000 O O   . HOH E 3 .   ? 19.708  34.574  18.600 1.00 31.91  ? 601 HOH A O   1 ? 
HETATM 5001 O O   . HOH E 3 .   ? 25.983  20.429  3.967  1.00 41.62  ? 602 HOH A O   1 ? 
HETATM 5002 O O   . HOH E 3 .   ? 10.950  24.703  17.788 1.00 17.75  ? 603 HOH A O   1 ? 
HETATM 5003 O O   . HOH E 3 .   ? 17.529  21.179  39.637 1.00 35.08  ? 604 HOH A O   1 ? 
HETATM 5004 O O   . HOH E 3 .   ? 22.086  32.106  34.077 1.00 32.64  ? 605 HOH A O   1 ? 
HETATM 5005 O O   . HOH E 3 .   ? 12.020  42.541  32.166 1.00 26.93  ? 606 HOH A O   1 ? 
HETATM 5006 O O   . HOH E 3 .   ? 12.387  23.939  20.399 1.00 17.10  ? 607 HOH A O   1 ? 
HETATM 5007 O O   . HOH E 3 .   ? 28.375  5.042   41.362 1.00 21.94  ? 608 HOH A O   1 ? 
HETATM 5008 O O   . HOH E 3 .   ? -2.061  23.551  17.510 1.00 35.42  ? 609 HOH A O   1 ? 
HETATM 5009 O O   . HOH E 3 .   ? 8.930   3.644   21.175 1.00 40.33  ? 610 HOH A O   1 ? 
HETATM 5010 O O   . HOH E 3 .   ? 28.445  12.346  40.361 1.00 21.91  ? 611 HOH A O   1 ? 
HETATM 5011 O O   . HOH E 3 .   ? -2.934  5.734   34.534 1.00 28.65  ? 612 HOH A O   1 ? 
HETATM 5012 O O   . HOH E 3 .   ? 3.397   14.279  22.009 1.00 22.52  ? 613 HOH A O   1 ? 
HETATM 5013 O O   . HOH E 3 .   ? 28.871  4.001   39.169 1.00 37.35  ? 614 HOH A O   1 ? 
HETATM 5014 O O   . HOH E 3 .   ? 6.053   2.795   47.694 1.00 25.76  ? 615 HOH A O   1 ? 
HETATM 5015 O O   . HOH E 3 .   ? 0.856   13.017  21.908 1.00 22.10  ? 616 HOH A O   1 ? 
HETATM 5016 O O   . HOH E 3 .   ? 14.470  -0.536  32.901 1.00 17.08  ? 617 HOH A O   1 ? 
HETATM 5017 O O   . HOH E 3 .   ? -3.111  14.716  41.638 1.00 36.34  ? 618 HOH A O   1 ? 
HETATM 5018 O O   . HOH E 3 .   ? 27.727  13.870  38.484 1.00 17.44  ? 619 HOH A O   1 ? 
HETATM 5019 O O   . HOH E 3 .   ? 20.591  3.016   18.366 1.00 20.99  ? 620 HOH A O   1 ? 
HETATM 5020 O O   . HOH E 3 .   ? 24.952  20.329  33.736 1.00 36.58  ? 621 HOH A O   1 ? 
HETATM 5021 O O   . HOH E 3 .   ? 13.370  -1.236  36.512 1.00 18.29  ? 622 HOH A O   1 ? 
HETATM 5022 O O   . HOH E 3 .   ? 16.179  2.682   4.723  1.00 37.18  ? 623 HOH A O   1 ? 
HETATM 5023 O O   . HOH E 3 .   ? -2.516  14.423  28.412 1.00 35.92  ? 624 HOH A O   1 ? 
HETATM 5024 O O   . HOH E 3 .   ? 28.757  12.032  45.673 1.00 35.05  ? 625 HOH A O   1 ? 
HETATM 5025 O O   . HOH E 3 .   ? 10.639  20.989  21.078 1.00 19.37  ? 626 HOH A O   1 ? 
HETATM 5026 O O   . HOH E 3 .   ? 1.601   26.672  40.060 1.00 33.34  ? 627 HOH A O   1 ? 
HETATM 5027 O O   . HOH E 3 .   ? 15.748  27.489  20.358 1.00 19.97  ? 628 HOH A O   1 ? 
HETATM 5028 O O   . HOH E 3 .   ? -2.835  15.233  7.578  1.00 31.78  ? 629 HOH A O   1 ? 
HETATM 5029 O O   . HOH E 3 .   ? 29.294  1.168   40.585 1.00 27.89  ? 630 HOH A O   1 ? 
HETATM 5030 O O   . HOH E 3 .   ? 19.121  30.893  16.970 1.00 30.27  ? 631 HOH A O   1 ? 
HETATM 5031 O O   . HOH E 3 .   ? 24.211  22.962  21.571 1.00 21.54  ? 632 HOH A O   1 ? 
HETATM 5032 O O   . HOH E 3 .   ? 8.732   5.956   16.599 1.00 24.25  ? 633 HOH A O   1 ? 
HETATM 5033 O O   . HOH E 3 .   ? 18.376  21.353  36.785 1.00 20.15  ? 634 HOH A O   1 ? 
HETATM 5034 O O   . HOH E 3 .   ? 0.187   16.171  43.681 1.00 26.83  ? 635 HOH A O   1 ? 
HETATM 5035 O O   . HOH E 3 .   ? 28.563  13.186  11.725 1.00 19.45  ? 636 HOH A O   1 ? 
HETATM 5036 O O   . HOH E 3 .   ? 12.624  9.523   16.480 1.00 17.90  ? 637 HOH A O   1 ? 
HETATM 5037 O O   . HOH E 3 .   ? -2.547  17.575  15.306 1.00 23.37  ? 638 HOH A O   1 ? 
HETATM 5038 O O   . HOH E 3 .   ? 32.389  11.662  12.679 1.00 26.38  ? 639 HOH A O   1 ? 
HETATM 5039 O O   . HOH E 3 .   ? 7.380   -0.437  24.209 1.00 32.30  ? 640 HOH A O   1 ? 
HETATM 5040 O O   . HOH E 3 .   ? 4.797   7.774   23.186 1.00 12.53  ? 641 HOH A O   1 ? 
HETATM 5041 O O   . HOH E 3 .   ? 22.836  1.268   49.765 1.00 30.02  ? 642 HOH A O   1 ? 
HETATM 5042 O O   . HOH E 3 .   ? 6.021   34.770  33.937 1.00 35.24  ? 643 HOH A O   1 ? 
HETATM 5043 O O   . HOH E 3 .   ? 0.385   30.055  31.900 1.00 28.15  ? 644 HOH A O   1 ? 
HETATM 5044 O O   . HOH E 3 .   ? -1.948  13.124  8.434  1.00 37.25  ? 645 HOH A O   1 ? 
HETATM 5045 O O   . HOH E 3 .   ? 19.186  24.014  35.625 1.00 30.96  ? 646 HOH A O   1 ? 
HETATM 5046 O O   . HOH E 3 .   ? 10.406  7.877   17.485 1.00 17.82  ? 647 HOH A O   1 ? 
HETATM 5047 O O   . HOH E 3 .   ? 13.869  -1.808  42.085 1.00 26.84  ? 648 HOH A O   1 ? 
HETATM 5048 O O   . HOH E 3 .   ? 11.335  -2.258  35.086 1.00 43.43  ? 649 HOH A O   1 ? 
HETATM 5049 O O   . HOH E 3 .   ? 25.236  13.588  3.382  1.00 28.57  ? 650 HOH A O   1 ? 
HETATM 5050 O O   . HOH E 3 .   ? 6.243   29.539  39.462 1.00 38.19  ? 651 HOH A O   1 ? 
HETATM 5051 O O   . HOH E 3 .   ? 1.495   1.879   27.092 1.00 37.81  ? 652 HOH A O   1 ? 
HETATM 5052 O O   . HOH E 3 .   ? 13.542  -1.804  11.365 1.00 33.97  ? 653 HOH A O   1 ? 
HETATM 5053 O O   . HOH E 3 .   ? 16.088  -1.766  54.072 1.00 46.47  ? 654 HOH A O   1 ? 
HETATM 5054 O O   . HOH E 3 .   ? -2.590  12.002  18.048 1.00 37.02  ? 655 HOH A O   1 ? 
HETATM 5055 O O   . HOH E 3 .   ? 32.087  19.317  23.259 1.00 37.02  ? 656 HOH A O   1 ? 
HETATM 5056 O O   . HOH E 3 .   ? 21.516  16.971  1.240  1.00 43.29  ? 657 HOH A O   1 ? 
HETATM 5057 O O   . HOH E 3 .   ? -1.935  14.431  43.609 1.00 29.19  ? 658 HOH A O   1 ? 
HETATM 5058 O O   . HOH E 3 .   ? 25.221  16.650  18.095 1.00 27.22  ? 659 HOH A O   1 ? 
HETATM 5059 O O   . HOH E 3 .   ? -5.238  16.133  15.075 1.00 25.97  ? 660 HOH A O   1 ? 
HETATM 5060 O O   . HOH E 3 .   ? 22.704  18.564  19.069 1.00 37.30  ? 661 HOH A O   1 ? 
HETATM 5061 O O   . HOH E 3 .   ? 11.860  11.513  14.874 1.00 19.16  ? 662 HOH A O   1 ? 
HETATM 5062 O O   . HOH E 3 .   ? 5.993   8.384   51.255 1.00 50.55  ? 663 HOH A O   1 ? 
HETATM 5063 O O   . HOH E 3 .   ? 3.250   6.186   46.074 1.00 42.87  ? 664 HOH A O   1 ? 
HETATM 5064 O O   . HOH E 3 .   ? 24.088  20.560  36.199 1.00 36.51  ? 665 HOH A O   1 ? 
HETATM 5065 O O   . HOH E 3 .   ? 5.066   -0.262  43.456 1.00 24.58  ? 666 HOH A O   1 ? 
HETATM 5066 O O   . HOH E 3 .   ? 25.335  19.939  40.449 1.00 36.66  ? 667 HOH A O   1 ? 
HETATM 5067 O O   . HOH E 3 .   ? 14.522  18.504  48.383 1.00 28.99  ? 668 HOH A O   1 ? 
HETATM 5068 O O   . HOH E 3 .   ? 8.564   29.956  4.002  1.00 37.86  ? 669 HOH A O   1 ? 
HETATM 5069 O O   . HOH E 3 .   ? 26.708  17.361  16.178 1.00 36.88  ? 670 HOH A O   1 ? 
HETATM 5070 O O   . HOH E 3 .   ? 2.328   6.380   22.796 1.00 23.48  ? 671 HOH A O   1 ? 
HETATM 5071 O O   . HOH E 3 .   ? -3.299  11.725  10.611 1.00 22.49  ? 672 HOH A O   1 ? 
HETATM 5072 O O   . HOH E 3 .   ? -5.195  16.233  39.508 1.00 16.91  ? 673 HOH A O   1 ? 
HETATM 5073 O O   . HOH F 3 .   ? -21.044 -20.382 36.750 1.00 28.01  ? 501 HOH B O   1 ? 
HETATM 5074 O O   . HOH F 3 .   ? 8.381   -7.565  45.898 1.00 27.90  ? 502 HOH B O   1 ? 
HETATM 5075 O O   . HOH F 3 .   ? -8.672  -24.928 39.029 1.00 12.12  ? 503 HOH B O   1 ? 
HETATM 5076 O O   . HOH F 3 .   ? -16.221 -17.062 30.150 1.00 26.89  ? 504 HOH B O   1 ? 
HETATM 5077 O O   . HOH F 3 .   ? -13.134 -12.315 42.835 1.00 27.91  ? 505 HOH B O   1 ? 
HETATM 5078 O O   . HOH F 3 .   ? -5.469  -1.463  22.229 1.00 34.85  ? 506 HOH B O   1 ? 
HETATM 5079 O O   . HOH F 3 .   ? -2.500  -1.471  54.520 1.00 30.88  ? 507 HOH B O   1 ? 
HETATM 5080 O O   . HOH F 3 .   ? -3.370  -3.490  34.445 1.00 24.77  ? 508 HOH B O   1 ? 
HETATM 5081 O O   . HOH F 3 .   ? -18.263 -18.938 30.549 1.00 24.77  ? 509 HOH B O   1 ? 
HETATM 5082 O O   . HOH F 3 .   ? 7.549   -19.443 15.538 1.00 28.50  ? 510 HOH B O   1 ? 
HETATM 5083 O O   . HOH F 3 .   ? 5.387   -28.367 30.365 1.00 30.44  ? 511 HOH B O   1 ? 
HETATM 5084 O O   . HOH F 3 .   ? -8.729  -22.156 48.991 1.00 17.76  ? 512 HOH B O   1 ? 
HETATM 5085 O O   . HOH F 3 .   ? 3.280   -1.924  42.004 1.00 25.40  ? 513 HOH B O   1 ? 
HETATM 5086 O O   . HOH F 3 .   ? -7.738  -28.995 32.994 1.00 20.80  ? 514 HOH B O   1 ? 
HETATM 5087 O O   . HOH F 3 .   ? -2.308  -3.378  39.739 1.00 14.94  ? 515 HOH B O   1 ? 
HETATM 5088 O O   . HOH F 3 .   ? -10.718 -15.395 20.647 1.00 24.13  ? 516 HOH B O   1 ? 
HETATM 5089 O O   . HOH F 3 .   ? -1.444  0.820   14.423 1.00 29.90  ? 517 HOH B O   1 ? 
HETATM 5090 O O   . HOH F 3 .   ? -0.235  -26.085 41.761 1.00 19.13  ? 518 HOH B O   1 ? 
HETATM 5091 O O   . HOH F 3 .   ? 4.035   -40.510 21.999 1.00 35.60  ? 519 HOH B O   1 ? 
HETATM 5092 O O   . HOH F 3 .   ? -8.239  -31.652 38.415 1.00 28.80  ? 520 HOH B O   1 ? 
HETATM 5093 O O   . HOH F 3 .   ? -14.154 -3.142  45.918 1.00 36.42  ? 521 HOH B O   1 ? 
HETATM 5094 O O   . HOH F 3 .   ? 8.420   -18.131 19.772 1.00 45.16  ? 522 HOH B O   1 ? 
HETATM 5095 O O   . HOH F 3 .   ? 0.276   -36.044 3.458  1.00 38.77  ? 523 HOH B O   1 ? 
HETATM 5096 O O   . HOH F 3 .   ? -5.179  -25.223 21.867 1.00 25.88  ? 524 HOH B O   1 ? 
HETATM 5097 O O   . HOH F 3 .   ? -3.654  -20.225 52.498 1.00 28.00  ? 525 HOH B O   1 ? 
HETATM 5098 O O   . HOH F 3 .   ? -19.642 -8.441  33.941 1.00 25.17  ? 526 HOH B O   1 ? 
HETATM 5099 O O   . HOH F 3 .   ? -10.460 -13.768 23.064 1.00 17.53  ? 527 HOH B O   1 ? 
HETATM 5100 O O   . HOH F 3 .   ? -2.073  -15.681 56.755 1.00 30.65  ? 528 HOH B O   1 ? 
HETATM 5101 O O   . HOH F 3 .   ? -11.571 -11.154 22.280 1.00 25.27  ? 529 HOH B O   1 ? 
HETATM 5102 O O   . HOH F 3 .   ? 7.279   -7.812  34.419 1.00 29.74  ? 530 HOH B O   1 ? 
HETATM 5103 O O   . HOH F 3 .   ? -9.271  -22.242 36.300 1.00 17.90  ? 531 HOH B O   1 ? 
HETATM 5104 O O   . HOH F 3 .   ? -8.452  -21.399 31.390 1.00 17.06  ? 532 HOH B O   1 ? 
HETATM 5105 O O   . HOH F 3 .   ? -7.790  -28.380 3.889  1.00 31.69  ? 533 HOH B O   1 ? 
HETATM 5106 O O   . HOH F 3 .   ? -13.990 -20.680 45.944 1.00 21.96  ? 534 HOH B O   1 ? 
HETATM 5107 O O   . HOH F 3 .   ? -1.563  -25.914 44.363 1.00 17.26  ? 535 HOH B O   1 ? 
HETATM 5108 O O   . HOH F 3 .   ? 4.650   -9.735  26.747 1.00 26.52  ? 536 HOH B O   1 ? 
HETATM 5109 O O   . HOH F 3 .   ? -3.702  -1.179  30.118 1.00 35.35  ? 537 HOH B O   1 ? 
HETATM 5110 O O   . HOH F 3 .   ? -10.916 -6.212  48.063 1.00 20.77  ? 538 HOH B O   1 ? 
HETATM 5111 O O   . HOH F 3 .   ? 10.265  -32.922 9.820  1.00 31.78  ? 539 HOH B O   1 ? 
HETATM 5112 O O   . HOH F 3 .   ? -6.755  -19.198 52.176 1.00 21.25  ? 540 HOH B O   1 ? 
HETATM 5113 O O   . HOH F 3 .   ? 8.683   -17.317 26.182 1.00 31.54  ? 541 HOH B O   1 ? 
HETATM 5114 O O   . HOH F 3 .   ? -9.547  -5.743  31.167 1.00 23.20  ? 542 HOH B O   1 ? 
HETATM 5115 O O   . HOH F 3 .   ? -9.942  -35.662 29.232 1.00 20.75  ? 543 HOH B O   1 ? 
HETATM 5116 O O   . HOH F 3 .   ? 1.487   -25.517 29.465 1.00 13.47  ? 544 HOH B O   1 ? 
HETATM 5117 O O   . HOH F 3 .   ? 0.798   -41.988 20.113 1.00 26.99  ? 545 HOH B O   1 ? 
HETATM 5118 O O   . HOH F 3 .   ? -1.026  -28.572 30.979 1.00 15.62  ? 546 HOH B O   1 ? 
HETATM 5119 O O   . HOH F 3 .   ? -2.615  -22.714 49.800 1.00 21.79  ? 547 HOH B O   1 ? 
HETATM 5120 O O   . HOH F 3 .   ? -7.438  -24.114 20.252 1.00 16.63  ? 548 HOH B O   1 ? 
HETATM 5121 O O   . HOH F 3 .   ? 4.080   -36.127 12.222 1.00 32.29  ? 549 HOH B O   1 ? 
HETATM 5122 O O   . HOH F 3 .   ? -15.239 -26.251 31.967 1.00 25.07  ? 550 HOH B O   1 ? 
HETATM 5123 O O   . HOH F 3 .   ? -10.767 -12.897 49.050 1.00 21.48  ? 551 HOH B O   1 ? 
HETATM 5124 O O   . HOH F 3 .   ? 4.859   -25.221 21.161 1.00 22.41  ? 552 HOH B O   1 ? 
HETATM 5125 O O   . HOH F 3 .   ? -18.672 -19.662 41.084 1.00 23.95  ? 553 HOH B O   1 ? 
HETATM 5126 O O   . HOH F 3 .   ? 4.249   -22.000 46.087 1.00 18.68  ? 554 HOH B O   1 ? 
HETATM 5127 O O   . HOH F 3 .   ? -8.410  -0.567  27.074 1.00 41.56  ? 555 HOH B O   1 ? 
HETATM 5128 O O   . HOH F 3 .   ? -6.671  -21.038 29.212 1.00 17.51  ? 556 HOH B O   1 ? 
HETATM 5129 O O   . HOH F 3 .   ? 4.666   -33.996 31.989 1.00 20.40  ? 557 HOH B O   1 ? 
HETATM 5130 O O   . HOH F 3 .   ? 10.243  -11.890 15.534 1.00 42.55  ? 558 HOH B O   1 ? 
HETATM 5131 O O   . HOH F 3 .   ? -15.335 -6.585  39.238 1.00 19.35  ? 559 HOH B O   1 ? 
HETATM 5132 O O   . HOH F 3 .   ? -12.138 -19.825 30.446 1.00 15.51  ? 560 HOH B O   1 ? 
HETATM 5133 O O   . HOH F 3 .   ? -13.257 -16.410 23.095 1.00 18.31  ? 561 HOH B O   1 ? 
HETATM 5134 O O   . HOH F 3 .   ? -1.993  -23.044 0.103  1.00 44.00  ? 562 HOH B O   1 ? 
HETATM 5135 O O   . HOH F 3 .   ? -10.470 3.466   35.283 1.00 24.90  ? 563 HOH B O   1 ? 
HETATM 5136 O O   . HOH F 3 .   ? -16.484 -28.759 26.895 1.00 25.80  ? 564 HOH B O   1 ? 
HETATM 5137 O O   . HOH F 3 .   ? 13.412  -29.564 21.866 1.00 32.33  ? 565 HOH B O   1 ? 
HETATM 5138 O O   . HOH F 3 .   ? 5.880   -37.530 10.445 1.00 41.74  ? 566 HOH B O   1 ? 
HETATM 5139 O O   . HOH F 3 .   ? -14.907 -18.224 25.014 1.00 30.66  ? 567 HOH B O   1 ? 
HETATM 5140 O O   . HOH F 3 .   ? -6.931  -19.575 34.852 1.00 15.84  ? 568 HOH B O   1 ? 
HETATM 5141 O O   . HOH F 3 .   ? 1.571   -11.238 10.052 1.00 38.46  ? 569 HOH B O   1 ? 
HETATM 5142 O O   . HOH F 3 .   ? -13.586 0.892   36.737 1.00 31.82  ? 570 HOH B O   1 ? 
HETATM 5143 O O   . HOH F 3 .   ? -3.233  -18.416 18.072 1.00 26.20  ? 571 HOH B O   1 ? 
HETATM 5144 O O   . HOH F 3 .   ? 6.509   -30.636 29.441 1.00 29.63  ? 572 HOH B O   1 ? 
HETATM 5145 O O   . HOH F 3 .   ? 7.237   -22.058 40.759 1.00 19.25  ? 573 HOH B O   1 ? 
HETATM 5146 O O   . HOH F 3 .   ? 5.981   -6.528  49.055 1.00 31.86  ? 574 HOH B O   1 ? 
HETATM 5147 O O   . HOH F 3 .   ? 13.869  -18.896 39.058 1.00 29.41  ? 575 HOH B O   1 ? 
HETATM 5148 O O   . HOH F 3 .   ? 7.526   -19.516 24.957 1.00 24.68  ? 576 HOH B O   1 ? 
HETATM 5149 O O   . HOH F 3 .   ? 2.015   -33.273 34.156 1.00 25.35  ? 577 HOH B O   1 ? 
HETATM 5150 O O   . HOH F 3 .   ? -10.047 -12.119 51.535 1.00 26.47  ? 578 HOH B O   1 ? 
HETATM 5151 O O   . HOH F 3 .   ? -13.442 -17.946 29.180 1.00 20.54  ? 579 HOH B O   1 ? 
HETATM 5152 O O   . HOH F 3 .   ? 9.496   -37.758 14.430 1.00 35.63  ? 580 HOH B O   1 ? 
HETATM 5153 O O   . HOH F 3 .   ? -15.118 -15.664 26.332 1.00 17.31  ? 581 HOH B O   1 ? 
HETATM 5154 O O   . HOH F 3 .   ? -3.108  2.386   44.351 1.00 27.11  ? 582 HOH B O   1 ? 
HETATM 5155 O O   . HOH F 3 .   ? 12.767  -31.944 20.124 1.00 20.17  ? 583 HOH B O   1 ? 
HETATM 5156 O O   . HOH F 3 .   ? -15.370 -26.047 36.623 1.00 27.20  ? 584 HOH B O   1 ? 
HETATM 5157 O O   . HOH F 3 .   ? -2.309  -16.554 16.411 1.00 24.22  ? 585 HOH B O   1 ? 
HETATM 5158 O O   . HOH F 3 .   ? 1.851   -17.991 13.871 1.00 30.01  ? 586 HOH B O   1 ? 
HETATM 5159 O O   . HOH F 3 .   ? 8.079   -23.221 18.451 1.00 30.91  ? 587 HOH B O   1 ? 
HETATM 5160 O O   . HOH F 3 .   ? -4.596  -19.765 15.775 1.00 22.48  ? 588 HOH B O   1 ? 
HETATM 5161 O O   . HOH F 3 .   ? -4.902  -19.843 20.706 1.00 19.08  ? 589 HOH B O   1 ? 
HETATM 5162 O O   . HOH F 3 .   ? 0.010   -24.595 39.688 1.00 14.59  ? 590 HOH B O   1 ? 
HETATM 5163 O O   . HOH F 3 .   ? -12.522 -2.226  50.121 1.00 29.73  ? 591 HOH B O   1 ? 
HETATM 5164 O O   . HOH F 3 .   ? 8.731   -30.343 30.579 1.00 31.46  ? 592 HOH B O   1 ? 
HETATM 5165 O O   . HOH F 3 .   ? -3.724  -17.451 23.539 1.00 14.62  ? 593 HOH B O   1 ? 
HETATM 5166 O O   . HOH F 3 .   ? -12.189 -23.638 26.163 1.00 22.90  ? 594 HOH B O   1 ? 
HETATM 5167 O O   . HOH F 3 .   ? 12.642  -11.049 40.166 1.00 36.58  ? 595 HOH B O   1 ? 
HETATM 5168 O O   . HOH F 3 .   ? 11.969  -11.987 37.712 1.00 18.20  ? 596 HOH B O   1 ? 
HETATM 5169 O O   . HOH F 3 .   ? -18.184 -26.544 19.176 1.00 26.82  ? 597 HOH B O   1 ? 
HETATM 5170 O O   . HOH F 3 .   ? 0.051   -23.070 51.906 1.00 26.12  ? 598 HOH B O   1 ? 
HETATM 5171 O O   . HOH F 3 .   ? -5.700  -29.106 22.587 1.00 16.80  ? 599 HOH B O   1 ? 
HETATM 5172 O O   . HOH F 3 .   ? -6.399  -21.557 33.126 1.00 15.32  ? 600 HOH B O   1 ? 
HETATM 5173 O O   . HOH F 3 .   ? 2.652   -8.004  30.916 1.00 22.88  ? 601 HOH B O   1 ? 
HETATM 5174 O O   . HOH F 3 .   ? -13.915 -16.274 47.473 1.00 21.51  ? 602 HOH B O   1 ? 
HETATM 5175 O O   . HOH F 3 .   ? -2.621  0.673   42.383 1.00 29.76  ? 603 HOH B O   1 ? 
HETATM 5176 O O   . HOH F 3 .   ? 1.863   -5.911  33.143 1.00 28.99  ? 604 HOH B O   1 ? 
HETATM 5177 O O   . HOH F 3 .   ? -13.307 -1.194  38.687 1.00 32.89  ? 605 HOH B O   1 ? 
HETATM 5178 O O   . HOH F 3 .   ? -2.227  -23.624 47.407 1.00 17.01  ? 606 HOH B O   1 ? 
HETATM 5179 O O   . HOH F 3 .   ? -0.433  -4.119  34.952 1.00 32.07  ? 607 HOH B O   1 ? 
HETATM 5180 O O   . HOH F 3 .   ? -14.736 -7.813  9.245  1.00 38.26  ? 608 HOH B O   1 ? 
HETATM 5181 O O   . HOH F 3 .   ? -6.757  -38.044 12.769 1.00 31.17  ? 609 HOH B O   1 ? 
HETATM 5182 O O   . HOH F 3 .   ? -0.114  -31.237 37.416 1.00 24.43  ? 610 HOH B O   1 ? 
HETATM 5183 O O   . HOH F 3 .   ? 0.192   -15.954 15.170 1.00 24.11  ? 611 HOH B O   1 ? 
HETATM 5184 O O   . HOH F 3 .   ? 1.239   -23.128 30.942 1.00 20.51  ? 612 HOH B O   1 ? 
HETATM 5185 O O   . HOH F 3 .   ? -21.347 -18.273 45.182 1.00 34.80  ? 613 HOH B O   1 ? 
HETATM 5186 O O   . HOH F 3 .   ? -7.070  -33.538 28.751 1.00 19.00  ? 614 HOH B O   1 ? 
HETATM 5187 O O   . HOH F 3 .   ? -5.658  2.048   51.035 1.00 24.59  ? 615 HOH B O   1 ? 
HETATM 5188 O O   . HOH F 3 .   ? 3.722   -2.415  36.431 1.00 32.76  ? 616 HOH B O   1 ? 
HETATM 5189 O O   . HOH F 3 .   ? -17.750 -9.057  23.240 1.00 34.30  ? 617 HOH B O   1 ? 
HETATM 5190 O O   . HOH F 3 .   ? 6.128   -6.148  46.615 1.00 31.33  ? 618 HOH B O   1 ? 
HETATM 5191 O O   . HOH F 3 .   ? -7.349  -31.570 33.431 1.00 34.45  ? 619 HOH B O   1 ? 
HETATM 5192 O O   . HOH F 3 .   ? 7.192   -20.627 34.825 1.00 29.14  ? 620 HOH B O   1 ? 
HETATM 5193 O O   . HOH F 3 .   ? 14.255  -35.981 21.669 1.00 24.14  ? 621 HOH B O   1 ? 
HETATM 5194 O O   . HOH F 3 .   ? -20.586 -27.730 20.123 1.00 33.61  ? 622 HOH B O   1 ? 
HETATM 5195 O O   . HOH F 3 .   ? -10.998 -27.125 31.748 1.00 9.89   ? 623 HOH B O   1 ? 
HETATM 5196 O O   . HOH F 3 .   ? -0.196  0.038   33.283 1.00 34.19  ? 624 HOH B O   1 ? 
HETATM 5197 O O   . HOH F 3 .   ? -3.159  -30.870 26.013 1.00 21.78  ? 625 HOH B O   1 ? 
HETATM 5198 O O   . HOH F 3 .   ? 0.618   -17.451 2.130  1.00 47.75  ? 626 HOH B O   1 ? 
HETATM 5199 O O   . HOH F 3 .   ? -10.897 -37.336 5.662  1.00 45.97  ? 627 HOH B O   1 ? 
HETATM 5200 O O   . HOH F 3 .   ? -4.456  -25.100 47.316 1.00 30.08  ? 628 HOH B O   1 ? 
HETATM 5201 O O   . HOH F 3 .   ? 6.846   -3.260  46.072 1.00 42.02  ? 629 HOH B O   1 ? 
HETATM 5202 O O   . HOH F 3 .   ? -2.652  -41.215 30.882 1.00 45.38  ? 630 HOH B O   1 ? 
HETATM 5203 O O   . HOH F 3 .   ? -9.707  -1.222  37.247 1.00 35.12  ? 631 HOH B O   1 ? 
HETATM 5204 O O   . HOH F 3 .   ? 7.508   -21.583 43.485 1.00 33.71  ? 632 HOH B O   1 ? 
HETATM 5205 O O   . HOH F 3 .   ? 7.646   -19.347 37.135 1.00 23.52  ? 633 HOH B O   1 ? 
HETATM 5206 O O   . HOH F 3 .   ? -13.592 -11.514 45.282 1.00 34.81  ? 634 HOH B O   1 ? 
HETATM 5207 O O   . HOH F 3 .   ? 5.194   -1.606  45.554 1.00 29.54  ? 635 HOH B O   1 ? 
HETATM 5208 O O   . HOH F 3 .   ? -12.327 -15.169 49.591 1.00 25.00  ? 636 HOH B O   1 ? 
HETATM 5209 O O   . HOH F 3 .   ? 8.801   -20.728 39.100 1.00 27.99  ? 637 HOH B O   1 ? 
HETATM 5210 O O   . HOH F 3 .   ? -13.544 -28.245 32.438 1.00 19.57  ? 638 HOH B O   1 ? 
HETATM 5211 O O   . HOH F 3 .   ? -12.713 -11.339 48.161 1.00 31.06  ? 639 HOH B O   1 ? 
HETATM 5212 O O   . HOH F 3 .   ? -1.135  -1.380  41.316 1.00 24.68  ? 640 HOH B O   1 ? 
HETATM 5213 O O   . HOH F 3 .   ? -14.689 -19.879 27.388 1.00 32.06  ? 641 HOH B O   1 ? 
HETATM 5214 O O   . HOH F 3 .   ? -22.683 -20.181 40.868 1.00 33.65  ? 642 HOH B O   1 ? 
HETATM 5215 O O   . HOH F 3 .   ? -10.817 -32.372 38.541 1.00 33.39  ? 643 HOH B O   1 ? 
HETATM 5216 O O   . HOH F 3 .   ? 6.651   -23.204 45.083 1.00 24.70  ? 644 HOH B O   1 ? 
HETATM 5217 O O   . HOH F 3 .   ? 1.326   -0.626  40.673 1.00 32.63  ? 645 HOH B O   1 ? 
HETATM 5218 O O   . HOH F 3 .   ? -11.403 -32.054 35.400 1.00 35.79  ? 646 HOH B O   1 ? 
HETATM 5219 O O   . HOH F 3 .   ? 8.974   -19.765 17.618 1.00 35.43  ? 647 HOH B O   1 ? 
# 
