data_9HH1
# 
_entry.id   9HH1 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9HH1         pdb_00009hh1 10.2210/pdb9hh1/pdb 
WWPDB D_1292143325 ?            ?                   
EMDB  EMD-52168    ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-16 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9HH1 
_pdbx_database_status.recvd_initial_deposition_date   2024-11-20 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'LysR Type Transcriptional Regulator LsrB from Agrobacterium tumefaciens' 
_pdbx_database_related.db_id          EMD-52168 
_pdbx_database_related.content_type   'associated EM volume' 
# 
loop_
_pdbx_contact_author.id 
_pdbx_contact_author.email 
_pdbx_contact_author.name_first 
_pdbx_contact_author.name_last 
_pdbx_contact_author.name_mi 
_pdbx_contact_author.role 
_pdbx_contact_author.identifier_ORCID 
2 franz.narberhaus@rub.de Franz   Narberhaus ? 'principal investigator/group leader' 0000-0002-8552-5310 
3 eckhard.hofmann@rub.de  Eckhard Hofmann    ? 'principal investigator/group leader' 0000-0003-4874-372X 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Elders, H.'     1 0009-0001-8534-5838 
'Schmidt, J.J.'  2 0009-0005-4526-4215 
'Fiedler, R.'    3 0009-0008-0838-7007 
'Hofmann, E.'    4 0000-0003-4874-372X 
'Narberhaus, F.' 5 0000-0002-8552-5310 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Nucleic Acids Res.' 
_citation.journal_id_ASTM           NARHAD 
_citation.journal_id_CSD            0389 
_citation.journal_id_ISSN           1362-4962 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            53 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Two redox-responsive LysR-type transcription factors control the oxidative stress response of Agrobacterium tumefaciens.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1093/nar/gkaf267 
_citation.pdbx_database_id_PubMed   40193708 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Schmidt, J.J.'     1  0009-0005-4526-4215 
primary 'Brandenburg, V.B.' 2  0000-0002-2443-2583 
primary 'Elders, H.'        3  0009-0001-8534-5838 
primary 'Shahzad, S.'       4  ?                   
primary 'Schakermann, S.'   5  0000-0001-7969-0005 
primary 'Fiedler, R.'       6  0009-0008-0838-7007 
primary 'Knoke, L.R.'       7  0000-0002-2424-1779 
primary 'Pfander, Y.'       8  ?                   
primary 'Dietze, P.'        9  ?                   
primary 'Bille, H.'         10 0009-0002-5714-2467 
primary 'Gartner, B.'       11 ?                   
primary 'Albin, L.J.'       12 ?                   
primary 'Leichert, L.I.'    13 0000-0002-5666-9681 
primary 'Bandow, J.E.'      14 0000-0003-4100-8829 
primary 'Hofmann, E.'       15 0000-0003-4874-372X 
primary 'Narberhaus, F.'    16 0000-0002-8552-5310 
# 
_entity.id                         1 
_entity.type                       polymer 
_entity.src_method                 man 
_entity.pdbx_description           'Transcriptional regulator, LysR family' 
_entity.formula_weight             35374.312 
_entity.pdbx_number_of_molecules   2 
_entity.pdbx_ec                    ? 
_entity.pdbx_mutation              ? 
_entity.pdbx_fragment              ? 
_entity.details                    ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MAMPLDWDKLRIFHAAAEAGSFTHAADKLHLSQSAISRQVSALEQDVGVKLFHRHARGLILTEQGELLYRTAHDVLLKLE
TVKMQLTETTEKPSGKLRVTTTVGLGQGWLTDKVQEFLQLYPEMSIQLILDNEELDVNMRHADCAIRLRQPQQSDLIQRK
LFTVHMHVYAAPSYINRHGEPQSVEDLDNHRIISFGEPAPNYLLDVNWLENAGRSSDNTRIPHLQINSQTSIKRACLLGI
GIACLPDYIVGRDPGLIQLSLAADIPSFDTYFCYPDEMKNAAKLKAFRDFIVAKARNWNFGTSAWSHPQFEK
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MAMPLDWDKLRIFHAAAEAGSFTHAADKLHLSQSAISRQVSALEQDVGVKLFHRHARGLILTEQGELLYRTAHDVLLKLE
TVKMQLTETTEKPSGKLRVTTTVGLGQGWLTDKVQEFLQLYPEMSIQLILDNEELDVNMRHADCAIRLRQPQQSDLIQRK
LFTVHMHVYAAPSYINRHGEPQSVEDLDNHRIISFGEPAPNYLLDVNWLENAGRSSDNTRIPHLQINSQTSIKRACLLGI
GIACLPDYIVGRDPGLIQLSLAADIPSFDTYFCYPDEMKNAAKLKAFRDFIVAKARNWNFGTSAWSHPQFEK
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ALA n 
1 3   MET n 
1 4   PRO n 
1 5   LEU n 
1 6   ASP n 
1 7   TRP n 
1 8   ASP n 
1 9   LYS n 
1 10  LEU n 
1 11  ARG n 
1 12  ILE n 
1 13  PHE n 
1 14  HIS n 
1 15  ALA n 
1 16  ALA n 
1 17  ALA n 
1 18  GLU n 
1 19  ALA n 
1 20  GLY n 
1 21  SER n 
1 22  PHE n 
1 23  THR n 
1 24  HIS n 
1 25  ALA n 
1 26  ALA n 
1 27  ASP n 
1 28  LYS n 
1 29  LEU n 
1 30  HIS n 
1 31  LEU n 
1 32  SER n 
1 33  GLN n 
1 34  SER n 
1 35  ALA n 
1 36  ILE n 
1 37  SER n 
1 38  ARG n 
1 39  GLN n 
1 40  VAL n 
1 41  SER n 
1 42  ALA n 
1 43  LEU n 
1 44  GLU n 
1 45  GLN n 
1 46  ASP n 
1 47  VAL n 
1 48  GLY n 
1 49  VAL n 
1 50  LYS n 
1 51  LEU n 
1 52  PHE n 
1 53  HIS n 
1 54  ARG n 
1 55  HIS n 
1 56  ALA n 
1 57  ARG n 
1 58  GLY n 
1 59  LEU n 
1 60  ILE n 
1 61  LEU n 
1 62  THR n 
1 63  GLU n 
1 64  GLN n 
1 65  GLY n 
1 66  GLU n 
1 67  LEU n 
1 68  LEU n 
1 69  TYR n 
1 70  ARG n 
1 71  THR n 
1 72  ALA n 
1 73  HIS n 
1 74  ASP n 
1 75  VAL n 
1 76  LEU n 
1 77  LEU n 
1 78  LYS n 
1 79  LEU n 
1 80  GLU n 
1 81  THR n 
1 82  VAL n 
1 83  LYS n 
1 84  MET n 
1 85  GLN n 
1 86  LEU n 
1 87  THR n 
1 88  GLU n 
1 89  THR n 
1 90  THR n 
1 91  GLU n 
1 92  LYS n 
1 93  PRO n 
1 94  SER n 
1 95  GLY n 
1 96  LYS n 
1 97  LEU n 
1 98  ARG n 
1 99  VAL n 
1 100 THR n 
1 101 THR n 
1 102 THR n 
1 103 VAL n 
1 104 GLY n 
1 105 LEU n 
1 106 GLY n 
1 107 GLN n 
1 108 GLY n 
1 109 TRP n 
1 110 LEU n 
1 111 THR n 
1 112 ASP n 
1 113 LYS n 
1 114 VAL n 
1 115 GLN n 
1 116 GLU n 
1 117 PHE n 
1 118 LEU n 
1 119 GLN n 
1 120 LEU n 
1 121 TYR n 
1 122 PRO n 
1 123 GLU n 
1 124 MET n 
1 125 SER n 
1 126 ILE n 
1 127 GLN n 
1 128 LEU n 
1 129 ILE n 
1 130 LEU n 
1 131 ASP n 
1 132 ASN n 
1 133 GLU n 
1 134 GLU n 
1 135 LEU n 
1 136 ASP n 
1 137 VAL n 
1 138 ASN n 
1 139 MET n 
1 140 ARG n 
1 141 HIS n 
1 142 ALA n 
1 143 ASP n 
1 144 CYS n 
1 145 ALA n 
1 146 ILE n 
1 147 ARG n 
1 148 LEU n 
1 149 ARG n 
1 150 GLN n 
1 151 PRO n 
1 152 GLN n 
1 153 GLN n 
1 154 SER n 
1 155 ASP n 
1 156 LEU n 
1 157 ILE n 
1 158 GLN n 
1 159 ARG n 
1 160 LYS n 
1 161 LEU n 
1 162 PHE n 
1 163 THR n 
1 164 VAL n 
1 165 HIS n 
1 166 MET n 
1 167 HIS n 
1 168 VAL n 
1 169 TYR n 
1 170 ALA n 
1 171 ALA n 
1 172 PRO n 
1 173 SER n 
1 174 TYR n 
1 175 ILE n 
1 176 ASN n 
1 177 ARG n 
1 178 HIS n 
1 179 GLY n 
1 180 GLU n 
1 181 PRO n 
1 182 GLN n 
1 183 SER n 
1 184 VAL n 
1 185 GLU n 
1 186 ASP n 
1 187 LEU n 
1 188 ASP n 
1 189 ASN n 
1 190 HIS n 
1 191 ARG n 
1 192 ILE n 
1 193 ILE n 
1 194 SER n 
1 195 PHE n 
1 196 GLY n 
1 197 GLU n 
1 198 PRO n 
1 199 ALA n 
1 200 PRO n 
1 201 ASN n 
1 202 TYR n 
1 203 LEU n 
1 204 LEU n 
1 205 ASP n 
1 206 VAL n 
1 207 ASN n 
1 208 TRP n 
1 209 LEU n 
1 210 GLU n 
1 211 ASN n 
1 212 ALA n 
1 213 GLY n 
1 214 ARG n 
1 215 SER n 
1 216 SER n 
1 217 ASP n 
1 218 ASN n 
1 219 THR n 
1 220 ARG n 
1 221 ILE n 
1 222 PRO n 
1 223 HIS n 
1 224 LEU n 
1 225 GLN n 
1 226 ILE n 
1 227 ASN n 
1 228 SER n 
1 229 GLN n 
1 230 THR n 
1 231 SER n 
1 232 ILE n 
1 233 LYS n 
1 234 ARG n 
1 235 ALA n 
1 236 CYS n 
1 237 LEU n 
1 238 LEU n 
1 239 GLY n 
1 240 ILE n 
1 241 GLY n 
1 242 ILE n 
1 243 ALA n 
1 244 CYS n 
1 245 LEU n 
1 246 PRO n 
1 247 ASP n 
1 248 TYR n 
1 249 ILE n 
1 250 VAL n 
1 251 GLY n 
1 252 ARG n 
1 253 ASP n 
1 254 PRO n 
1 255 GLY n 
1 256 LEU n 
1 257 ILE n 
1 258 GLN n 
1 259 LEU n 
1 260 SER n 
1 261 LEU n 
1 262 ALA n 
1 263 ALA n 
1 264 ASP n 
1 265 ILE n 
1 266 PRO n 
1 267 SER n 
1 268 PHE n 
1 269 ASP n 
1 270 THR n 
1 271 TYR n 
1 272 PHE n 
1 273 CYS n 
1 274 TYR n 
1 275 PRO n 
1 276 ASP n 
1 277 GLU n 
1 278 MET n 
1 279 LYS n 
1 280 ASN n 
1 281 ALA n 
1 282 ALA n 
1 283 LYS n 
1 284 LEU n 
1 285 LYS n 
1 286 ALA n 
1 287 PHE n 
1 288 ARG n 
1 289 ASP n 
1 290 PHE n 
1 291 ILE n 
1 292 VAL n 
1 293 ALA n 
1 294 LYS n 
1 295 ALA n 
1 296 ARG n 
1 297 ASN n 
1 298 TRP n 
1 299 ASN n 
1 300 PHE n 
1 301 GLY n 
1 302 THR n 
1 303 SER n 
1 304 ALA n 
1 305 TRP n 
1 306 SER n 
1 307 HIS n 
1 308 PRO n 
1 309 GLN n 
1 310 PHE n 
1 311 GLU n 
1 312 LYS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   312 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 Atu2186 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Agrobacterium fabrum str. C58' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     176299 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   ALA 2   2   ?   ?   ?   A . n 
A 1 3   MET 3   3   ?   ?   ?   A . n 
A 1 4   PRO 4   4   ?   ?   ?   A . n 
A 1 5   LEU 5   5   ?   ?   ?   A . n 
A 1 6   ASP 6   6   ?   ?   ?   A . n 
A 1 7   TRP 7   7   ?   ?   ?   A . n 
A 1 8   ASP 8   8   ?   ?   ?   A . n 
A 1 9   LYS 9   9   ?   ?   ?   A . n 
A 1 10  LEU 10  10  ?   ?   ?   A . n 
A 1 11  ARG 11  11  ?   ?   ?   A . n 
A 1 12  ILE 12  12  ?   ?   ?   A . n 
A 1 13  PHE 13  13  ?   ?   ?   A . n 
A 1 14  HIS 14  14  ?   ?   ?   A . n 
A 1 15  ALA 15  15  ?   ?   ?   A . n 
A 1 16  ALA 16  16  ?   ?   ?   A . n 
A 1 17  ALA 17  17  ?   ?   ?   A . n 
A 1 18  GLU 18  18  ?   ?   ?   A . n 
A 1 19  ALA 19  19  ?   ?   ?   A . n 
A 1 20  GLY 20  20  ?   ?   ?   A . n 
A 1 21  SER 21  21  ?   ?   ?   A . n 
A 1 22  PHE 22  22  ?   ?   ?   A . n 
A 1 23  THR 23  23  ?   ?   ?   A . n 
A 1 24  HIS 24  24  ?   ?   ?   A . n 
A 1 25  ALA 25  25  ?   ?   ?   A . n 
A 1 26  ALA 26  26  ?   ?   ?   A . n 
A 1 27  ASP 27  27  ?   ?   ?   A . n 
A 1 28  LYS 28  28  ?   ?   ?   A . n 
A 1 29  LEU 29  29  ?   ?   ?   A . n 
A 1 30  HIS 30  30  ?   ?   ?   A . n 
A 1 31  LEU 31  31  ?   ?   ?   A . n 
A 1 32  SER 32  32  ?   ?   ?   A . n 
A 1 33  GLN 33  33  ?   ?   ?   A . n 
A 1 34  SER 34  34  ?   ?   ?   A . n 
A 1 35  ALA 35  35  ?   ?   ?   A . n 
A 1 36  ILE 36  36  ?   ?   ?   A . n 
A 1 37  SER 37  37  ?   ?   ?   A . n 
A 1 38  ARG 38  38  ?   ?   ?   A . n 
A 1 39  GLN 39  39  ?   ?   ?   A . n 
A 1 40  VAL 40  40  ?   ?   ?   A . n 
A 1 41  SER 41  41  ?   ?   ?   A . n 
A 1 42  ALA 42  42  ?   ?   ?   A . n 
A 1 43  LEU 43  43  ?   ?   ?   A . n 
A 1 44  GLU 44  44  ?   ?   ?   A . n 
A 1 45  GLN 45  45  ?   ?   ?   A . n 
A 1 46  ASP 46  46  ?   ?   ?   A . n 
A 1 47  VAL 47  47  ?   ?   ?   A . n 
A 1 48  GLY 48  48  ?   ?   ?   A . n 
A 1 49  VAL 49  49  ?   ?   ?   A . n 
A 1 50  LYS 50  50  ?   ?   ?   A . n 
A 1 51  LEU 51  51  ?   ?   ?   A . n 
A 1 52  PHE 52  52  ?   ?   ?   A . n 
A 1 53  HIS 53  53  ?   ?   ?   A . n 
A 1 54  ARG 54  54  ?   ?   ?   A . n 
A 1 55  HIS 55  55  ?   ?   ?   A . n 
A 1 56  ALA 56  56  ?   ?   ?   A . n 
A 1 57  ARG 57  57  ?   ?   ?   A . n 
A 1 58  GLY 58  58  ?   ?   ?   A . n 
A 1 59  LEU 59  59  ?   ?   ?   A . n 
A 1 60  ILE 60  60  ?   ?   ?   A . n 
A 1 61  LEU 61  61  ?   ?   ?   A . n 
A 1 62  THR 62  62  ?   ?   ?   A . n 
A 1 63  GLU 63  63  ?   ?   ?   A . n 
A 1 64  GLN 64  64  ?   ?   ?   A . n 
A 1 65  GLY 65  65  ?   ?   ?   A . n 
A 1 66  GLU 66  66  ?   ?   ?   A . n 
A 1 67  LEU 67  67  ?   ?   ?   A . n 
A 1 68  LEU 68  68  ?   ?   ?   A . n 
A 1 69  TYR 69  69  ?   ?   ?   A . n 
A 1 70  ARG 70  70  ?   ?   ?   A . n 
A 1 71  THR 71  71  ?   ?   ?   A . n 
A 1 72  ALA 72  72  ?   ?   ?   A . n 
A 1 73  HIS 73  73  ?   ?   ?   A . n 
A 1 74  ASP 74  74  ?   ?   ?   A . n 
A 1 75  VAL 75  75  ?   ?   ?   A . n 
A 1 76  LEU 76  76  ?   ?   ?   A . n 
A 1 77  LEU 77  77  ?   ?   ?   A . n 
A 1 78  LYS 78  78  ?   ?   ?   A . n 
A 1 79  LEU 79  79  ?   ?   ?   A . n 
A 1 80  GLU 80  80  ?   ?   ?   A . n 
A 1 81  THR 81  81  ?   ?   ?   A . n 
A 1 82  VAL 82  82  ?   ?   ?   A . n 
A 1 83  LYS 83  83  ?   ?   ?   A . n 
A 1 84  MET 84  84  ?   ?   ?   A . n 
A 1 85  GLN 85  85  ?   ?   ?   A . n 
A 1 86  LEU 86  86  ?   ?   ?   A . n 
A 1 87  THR 87  87  ?   ?   ?   A . n 
A 1 88  GLU 88  88  ?   ?   ?   A . n 
A 1 89  THR 89  89  ?   ?   ?   A . n 
A 1 90  THR 90  90  ?   ?   ?   A . n 
A 1 91  GLU 91  91  ?   ?   ?   A . n 
A 1 92  LYS 92  92  ?   ?   ?   A . n 
A 1 93  PRO 93  93  ?   ?   ?   A . n 
A 1 94  SER 94  94  ?   ?   ?   A . n 
A 1 95  GLY 95  95  95  GLY GLY A . n 
A 1 96  LYS 96  96  96  LYS LYS A . n 
A 1 97  LEU 97  97  97  LEU LEU A . n 
A 1 98  ARG 98  98  98  ARG ARG A . n 
A 1 99  VAL 99  99  99  VAL VAL A . n 
A 1 100 THR 100 100 100 THR THR A . n 
A 1 101 THR 101 101 101 THR THR A . n 
A 1 102 THR 102 102 102 THR THR A . n 
A 1 103 VAL 103 103 103 VAL VAL A . n 
A 1 104 GLY 104 104 104 GLY GLY A . n 
A 1 105 LEU 105 105 105 LEU LEU A . n 
A 1 106 GLY 106 106 106 GLY GLY A . n 
A 1 107 GLN 107 107 107 GLN GLN A . n 
A 1 108 GLY 108 108 108 GLY GLY A . n 
A 1 109 TRP 109 109 109 TRP TRP A . n 
A 1 110 LEU 110 110 110 LEU LEU A . n 
A 1 111 THR 111 111 111 THR THR A . n 
A 1 112 ASP 112 112 112 ASP ASP A . n 
A 1 113 LYS 113 113 113 LYS LYS A . n 
A 1 114 VAL 114 114 114 VAL VAL A . n 
A 1 115 GLN 115 115 115 GLN GLN A . n 
A 1 116 GLU 116 116 116 GLU GLU A . n 
A 1 117 PHE 117 117 117 PHE PHE A . n 
A 1 118 LEU 118 118 118 LEU LEU A . n 
A 1 119 GLN 119 119 119 GLN GLN A . n 
A 1 120 LEU 120 120 120 LEU LEU A . n 
A 1 121 TYR 121 121 121 TYR TYR A . n 
A 1 122 PRO 122 122 122 PRO PRO A . n 
A 1 123 GLU 123 123 123 GLU GLU A . n 
A 1 124 MET 124 124 124 MET MET A . n 
A 1 125 SER 125 125 125 SER SER A . n 
A 1 126 ILE 126 126 126 ILE ILE A . n 
A 1 127 GLN 127 127 127 GLN GLN A . n 
A 1 128 LEU 128 128 128 LEU LEU A . n 
A 1 129 ILE 129 129 129 ILE ILE A . n 
A 1 130 LEU 130 130 130 LEU LEU A . n 
A 1 131 ASP 131 131 131 ASP ASP A . n 
A 1 132 ASN 132 132 132 ASN ASN A . n 
A 1 133 GLU 133 133 133 GLU GLU A . n 
A 1 134 GLU 134 134 134 GLU GLU A . n 
A 1 135 LEU 135 135 135 LEU LEU A . n 
A 1 136 ASP 136 136 136 ASP ASP A . n 
A 1 137 VAL 137 137 137 VAL VAL A . n 
A 1 138 ASN 138 138 138 ASN ASN A . n 
A 1 139 MET 139 139 139 MET MET A . n 
A 1 140 ARG 140 140 140 ARG ARG A . n 
A 1 141 HIS 141 141 141 HIS HIS A . n 
A 1 142 ALA 142 142 142 ALA ALA A . n 
A 1 143 ASP 143 143 143 ASP ASP A . n 
A 1 144 CYS 144 144 144 CYS CYS A . n 
A 1 145 ALA 145 145 145 ALA ALA A . n 
A 1 146 ILE 146 146 146 ILE ILE A . n 
A 1 147 ARG 147 147 147 ARG ARG A . n 
A 1 148 LEU 148 148 148 LEU LEU A . n 
A 1 149 ARG 149 149 149 ARG ARG A . n 
A 1 150 GLN 150 150 150 GLN GLN A . n 
A 1 151 PRO 151 151 151 PRO PRO A . n 
A 1 152 GLN 152 152 152 GLN GLN A . n 
A 1 153 GLN 153 153 153 GLN GLN A . n 
A 1 154 SER 154 154 154 SER SER A . n 
A 1 155 ASP 155 155 155 ASP ASP A . n 
A 1 156 LEU 156 156 156 LEU LEU A . n 
A 1 157 ILE 157 157 157 ILE ILE A . n 
A 1 158 GLN 158 158 158 GLN GLN A . n 
A 1 159 ARG 159 159 159 ARG ARG A . n 
A 1 160 LYS 160 160 160 LYS LYS A . n 
A 1 161 LEU 161 161 161 LEU LEU A . n 
A 1 162 PHE 162 162 162 PHE PHE A . n 
A 1 163 THR 163 163 163 THR THR A . n 
A 1 164 VAL 164 164 164 VAL VAL A . n 
A 1 165 HIS 165 165 165 HIS HIS A . n 
A 1 166 MET 166 166 166 MET MET A . n 
A 1 167 HIS 167 167 167 HIS HIS A . n 
A 1 168 VAL 168 168 168 VAL VAL A . n 
A 1 169 TYR 169 169 169 TYR TYR A . n 
A 1 170 ALA 170 170 170 ALA ALA A . n 
A 1 171 ALA 171 171 171 ALA ALA A . n 
A 1 172 PRO 172 172 172 PRO PRO A . n 
A 1 173 SER 173 173 173 SER SER A . n 
A 1 174 TYR 174 174 174 TYR TYR A . n 
A 1 175 ILE 175 175 175 ILE ILE A . n 
A 1 176 ASN 176 176 176 ASN ASN A . n 
A 1 177 ARG 177 177 177 ARG ARG A . n 
A 1 178 HIS 178 178 178 HIS HIS A . n 
A 1 179 GLY 179 179 179 GLY GLY A . n 
A 1 180 GLU 180 180 180 GLU GLU A . n 
A 1 181 PRO 181 181 181 PRO PRO A . n 
A 1 182 GLN 182 182 182 GLN GLN A . n 
A 1 183 SER 183 183 183 SER SER A . n 
A 1 184 VAL 184 184 184 VAL VAL A . n 
A 1 185 GLU 185 185 185 GLU GLU A . n 
A 1 186 ASP 186 186 186 ASP ASP A . n 
A 1 187 LEU 187 187 187 LEU LEU A . n 
A 1 188 ASP 188 188 188 ASP ASP A . n 
A 1 189 ASN 189 189 189 ASN ASN A . n 
A 1 190 HIS 190 190 190 HIS HIS A . n 
A 1 191 ARG 191 191 191 ARG ARG A . n 
A 1 192 ILE 192 192 192 ILE ILE A . n 
A 1 193 ILE 193 193 193 ILE ILE A . n 
A 1 194 SER 194 194 194 SER SER A . n 
A 1 195 PHE 195 195 195 PHE PHE A . n 
A 1 196 GLY 196 196 196 GLY GLY A . n 
A 1 197 GLU 197 197 197 GLU GLU A . n 
A 1 198 PRO 198 198 198 PRO PRO A . n 
A 1 199 ALA 199 199 199 ALA ALA A . n 
A 1 200 PRO 200 200 200 PRO PRO A . n 
A 1 201 ASN 201 201 201 ASN ASN A . n 
A 1 202 TYR 202 202 202 TYR TYR A . n 
A 1 203 LEU 203 203 203 LEU LEU A . n 
A 1 204 LEU 204 204 204 LEU LEU A . n 
A 1 205 ASP 205 205 205 ASP ASP A . n 
A 1 206 VAL 206 206 206 VAL VAL A . n 
A 1 207 ASN 207 207 207 ASN ASN A . n 
A 1 208 TRP 208 208 208 TRP TRP A . n 
A 1 209 LEU 209 209 209 LEU LEU A . n 
A 1 210 GLU 210 210 210 GLU GLU A . n 
A 1 211 ASN 211 211 211 ASN ASN A . n 
A 1 212 ALA 212 212 212 ALA ALA A . n 
A 1 213 GLY 213 213 213 GLY GLY A . n 
A 1 214 ARG 214 214 214 ARG ARG A . n 
A 1 215 SER 215 215 215 SER SER A . n 
A 1 216 SER 216 216 216 SER SER A . n 
A 1 217 ASP 217 217 217 ASP ASP A . n 
A 1 218 ASN 218 218 218 ASN ASN A . n 
A 1 219 THR 219 219 219 THR THR A . n 
A 1 220 ARG 220 220 220 ARG ARG A . n 
A 1 221 ILE 221 221 221 ILE ILE A . n 
A 1 222 PRO 222 222 222 PRO PRO A . n 
A 1 223 HIS 223 223 223 HIS HIS A . n 
A 1 224 LEU 224 224 224 LEU LEU A . n 
A 1 225 GLN 225 225 225 GLN GLN A . n 
A 1 226 ILE 226 226 226 ILE ILE A . n 
A 1 227 ASN 227 227 227 ASN ASN A . n 
A 1 228 SER 228 228 228 SER SER A . n 
A 1 229 GLN 229 229 229 GLN GLN A . n 
A 1 230 THR 230 230 230 THR THR A . n 
A 1 231 SER 231 231 231 SER SER A . n 
A 1 232 ILE 232 232 232 ILE ILE A . n 
A 1 233 LYS 233 233 233 LYS LYS A . n 
A 1 234 ARG 234 234 234 ARG ARG A . n 
A 1 235 ALA 235 235 235 ALA ALA A . n 
A 1 236 CYS 236 236 236 CYS CYS A . n 
A 1 237 LEU 237 237 237 LEU LEU A . n 
A 1 238 LEU 238 238 238 LEU LEU A . n 
A 1 239 GLY 239 239 239 GLY GLY A . n 
A 1 240 ILE 240 240 240 ILE ILE A . n 
A 1 241 GLY 241 241 241 GLY GLY A . n 
A 1 242 ILE 242 242 242 ILE ILE A . n 
A 1 243 ALA 243 243 243 ALA ALA A . n 
A 1 244 CYS 244 244 244 CYS CYS A . n 
A 1 245 LEU 245 245 245 LEU LEU A . n 
A 1 246 PRO 246 246 246 PRO PRO A . n 
A 1 247 ASP 247 247 247 ASP ASP A . n 
A 1 248 TYR 248 248 248 TYR TYR A . n 
A 1 249 ILE 249 249 249 ILE ILE A . n 
A 1 250 VAL 250 250 250 VAL VAL A . n 
A 1 251 GLY 251 251 251 GLY GLY A . n 
A 1 252 ARG 252 252 252 ARG ARG A . n 
A 1 253 ASP 253 253 253 ASP ASP A . n 
A 1 254 PRO 254 254 254 PRO PRO A . n 
A 1 255 GLY 255 255 255 GLY GLY A . n 
A 1 256 LEU 256 256 256 LEU LEU A . n 
A 1 257 ILE 257 257 257 ILE ILE A . n 
A 1 258 GLN 258 258 258 GLN GLN A . n 
A 1 259 LEU 259 259 259 LEU LEU A . n 
A 1 260 SER 260 260 260 SER SER A . n 
A 1 261 LEU 261 261 261 LEU LEU A . n 
A 1 262 ALA 262 262 262 ALA ALA A . n 
A 1 263 ALA 263 263 263 ALA ALA A . n 
A 1 264 ASP 264 264 264 ASP ASP A . n 
A 1 265 ILE 265 265 265 ILE ILE A . n 
A 1 266 PRO 266 266 266 PRO PRO A . n 
A 1 267 SER 267 267 267 SER SER A . n 
A 1 268 PHE 268 268 268 PHE PHE A . n 
A 1 269 ASP 269 269 269 ASP ASP A . n 
A 1 270 THR 270 270 270 THR THR A . n 
A 1 271 TYR 271 271 271 TYR TYR A . n 
A 1 272 PHE 272 272 272 PHE PHE A . n 
A 1 273 CYS 273 273 273 CYS CYS A . n 
A 1 274 TYR 274 274 274 TYR TYR A . n 
A 1 275 PRO 275 275 275 PRO PRO A . n 
A 1 276 ASP 276 276 276 ASP ASP A . n 
A 1 277 GLU 277 277 277 GLU GLU A . n 
A 1 278 MET 278 278 278 MET MET A . n 
A 1 279 LYS 279 279 279 LYS LYS A . n 
A 1 280 ASN 280 280 280 ASN ASN A . n 
A 1 281 ALA 281 281 281 ALA ALA A . n 
A 1 282 ALA 282 282 282 ALA ALA A . n 
A 1 283 LYS 283 283 283 LYS LYS A . n 
A 1 284 LEU 284 284 284 LEU LEU A . n 
A 1 285 LYS 285 285 285 LYS LYS A . n 
A 1 286 ALA 286 286 286 ALA ALA A . n 
A 1 287 PHE 287 287 287 PHE PHE A . n 
A 1 288 ARG 288 288 288 ARG ARG A . n 
A 1 289 ASP 289 289 289 ASP ASP A . n 
A 1 290 PHE 290 290 290 PHE PHE A . n 
A 1 291 ILE 291 291 291 ILE ILE A . n 
A 1 292 VAL 292 292 292 VAL VAL A . n 
A 1 293 ALA 293 293 293 ALA ALA A . n 
A 1 294 LYS 294 294 294 LYS LYS A . n 
A 1 295 ALA 295 295 295 ALA ALA A . n 
A 1 296 ARG 296 296 296 ARG ARG A . n 
A 1 297 ASN 297 297 297 ASN ASN A . n 
A 1 298 TRP 298 298 298 TRP TRP A . n 
A 1 299 ASN 299 299 299 ASN ASN A . n 
A 1 300 PHE 300 300 300 PHE PHE A . n 
A 1 301 GLY 301 301 ?   ?   ?   A . n 
A 1 302 THR 302 302 ?   ?   ?   A . n 
A 1 303 SER 303 303 ?   ?   ?   A . n 
A 1 304 ALA 304 304 ?   ?   ?   A . n 
A 1 305 TRP 305 305 ?   ?   ?   A . n 
A 1 306 SER 306 306 ?   ?   ?   A . n 
A 1 307 HIS 307 307 ?   ?   ?   A . n 
A 1 308 PRO 308 308 ?   ?   ?   A . n 
A 1 309 GLN 309 309 ?   ?   ?   A . n 
A 1 310 PHE 310 310 ?   ?   ?   A . n 
A 1 311 GLU 311 311 ?   ?   ?   A . n 
A 1 312 LYS 312 312 ?   ?   ?   A . n 
B 1 1   MET 1   1   ?   ?   ?   B . n 
B 1 2   ALA 2   2   ?   ?   ?   B . n 
B 1 3   MET 3   3   ?   ?   ?   B . n 
B 1 4   PRO 4   4   ?   ?   ?   B . n 
B 1 5   LEU 5   5   ?   ?   ?   B . n 
B 1 6   ASP 6   6   ?   ?   ?   B . n 
B 1 7   TRP 7   7   ?   ?   ?   B . n 
B 1 8   ASP 8   8   ?   ?   ?   B . n 
B 1 9   LYS 9   9   ?   ?   ?   B . n 
B 1 10  LEU 10  10  ?   ?   ?   B . n 
B 1 11  ARG 11  11  ?   ?   ?   B . n 
B 1 12  ILE 12  12  ?   ?   ?   B . n 
B 1 13  PHE 13  13  ?   ?   ?   B . n 
B 1 14  HIS 14  14  ?   ?   ?   B . n 
B 1 15  ALA 15  15  ?   ?   ?   B . n 
B 1 16  ALA 16  16  ?   ?   ?   B . n 
B 1 17  ALA 17  17  ?   ?   ?   B . n 
B 1 18  GLU 18  18  ?   ?   ?   B . n 
B 1 19  ALA 19  19  ?   ?   ?   B . n 
B 1 20  GLY 20  20  ?   ?   ?   B . n 
B 1 21  SER 21  21  ?   ?   ?   B . n 
B 1 22  PHE 22  22  ?   ?   ?   B . n 
B 1 23  THR 23  23  ?   ?   ?   B . n 
B 1 24  HIS 24  24  ?   ?   ?   B . n 
B 1 25  ALA 25  25  ?   ?   ?   B . n 
B 1 26  ALA 26  26  ?   ?   ?   B . n 
B 1 27  ASP 27  27  ?   ?   ?   B . n 
B 1 28  LYS 28  28  ?   ?   ?   B . n 
B 1 29  LEU 29  29  ?   ?   ?   B . n 
B 1 30  HIS 30  30  ?   ?   ?   B . n 
B 1 31  LEU 31  31  ?   ?   ?   B . n 
B 1 32  SER 32  32  ?   ?   ?   B . n 
B 1 33  GLN 33  33  ?   ?   ?   B . n 
B 1 34  SER 34  34  ?   ?   ?   B . n 
B 1 35  ALA 35  35  ?   ?   ?   B . n 
B 1 36  ILE 36  36  ?   ?   ?   B . n 
B 1 37  SER 37  37  ?   ?   ?   B . n 
B 1 38  ARG 38  38  ?   ?   ?   B . n 
B 1 39  GLN 39  39  ?   ?   ?   B . n 
B 1 40  VAL 40  40  ?   ?   ?   B . n 
B 1 41  SER 41  41  ?   ?   ?   B . n 
B 1 42  ALA 42  42  ?   ?   ?   B . n 
B 1 43  LEU 43  43  ?   ?   ?   B . n 
B 1 44  GLU 44  44  ?   ?   ?   B . n 
B 1 45  GLN 45  45  ?   ?   ?   B . n 
B 1 46  ASP 46  46  ?   ?   ?   B . n 
B 1 47  VAL 47  47  ?   ?   ?   B . n 
B 1 48  GLY 48  48  ?   ?   ?   B . n 
B 1 49  VAL 49  49  ?   ?   ?   B . n 
B 1 50  LYS 50  50  ?   ?   ?   B . n 
B 1 51  LEU 51  51  ?   ?   ?   B . n 
B 1 52  PHE 52  52  ?   ?   ?   B . n 
B 1 53  HIS 53  53  ?   ?   ?   B . n 
B 1 54  ARG 54  54  ?   ?   ?   B . n 
B 1 55  HIS 55  55  ?   ?   ?   B . n 
B 1 56  ALA 56  56  ?   ?   ?   B . n 
B 1 57  ARG 57  57  ?   ?   ?   B . n 
B 1 58  GLY 58  58  ?   ?   ?   B . n 
B 1 59  LEU 59  59  ?   ?   ?   B . n 
B 1 60  ILE 60  60  ?   ?   ?   B . n 
B 1 61  LEU 61  61  ?   ?   ?   B . n 
B 1 62  THR 62  62  ?   ?   ?   B . n 
B 1 63  GLU 63  63  ?   ?   ?   B . n 
B 1 64  GLN 64  64  ?   ?   ?   B . n 
B 1 65  GLY 65  65  ?   ?   ?   B . n 
B 1 66  GLU 66  66  ?   ?   ?   B . n 
B 1 67  LEU 67  67  ?   ?   ?   B . n 
B 1 68  LEU 68  68  ?   ?   ?   B . n 
B 1 69  TYR 69  69  ?   ?   ?   B . n 
B 1 70  ARG 70  70  ?   ?   ?   B . n 
B 1 71  THR 71  71  ?   ?   ?   B . n 
B 1 72  ALA 72  72  ?   ?   ?   B . n 
B 1 73  HIS 73  73  ?   ?   ?   B . n 
B 1 74  ASP 74  74  ?   ?   ?   B . n 
B 1 75  VAL 75  75  ?   ?   ?   B . n 
B 1 76  LEU 76  76  ?   ?   ?   B . n 
B 1 77  LEU 77  77  ?   ?   ?   B . n 
B 1 78  LYS 78  78  ?   ?   ?   B . n 
B 1 79  LEU 79  79  ?   ?   ?   B . n 
B 1 80  GLU 80  80  ?   ?   ?   B . n 
B 1 81  THR 81  81  ?   ?   ?   B . n 
B 1 82  VAL 82  82  ?   ?   ?   B . n 
B 1 83  LYS 83  83  ?   ?   ?   B . n 
B 1 84  MET 84  84  ?   ?   ?   B . n 
B 1 85  GLN 85  85  ?   ?   ?   B . n 
B 1 86  LEU 86  86  ?   ?   ?   B . n 
B 1 87  THR 87  87  ?   ?   ?   B . n 
B 1 88  GLU 88  88  ?   ?   ?   B . n 
B 1 89  THR 89  89  ?   ?   ?   B . n 
B 1 90  THR 90  90  ?   ?   ?   B . n 
B 1 91  GLU 91  91  ?   ?   ?   B . n 
B 1 92  LYS 92  92  ?   ?   ?   B . n 
B 1 93  PRO 93  93  ?   ?   ?   B . n 
B 1 94  SER 94  94  ?   ?   ?   B . n 
B 1 95  GLY 95  95  95  GLY GLY B . n 
B 1 96  LYS 96  96  96  LYS LYS B . n 
B 1 97  LEU 97  97  97  LEU LEU B . n 
B 1 98  ARG 98  98  98  ARG ARG B . n 
B 1 99  VAL 99  99  99  VAL VAL B . n 
B 1 100 THR 100 100 100 THR THR B . n 
B 1 101 THR 101 101 101 THR THR B . n 
B 1 102 THR 102 102 102 THR THR B . n 
B 1 103 VAL 103 103 103 VAL VAL B . n 
B 1 104 GLY 104 104 104 GLY GLY B . n 
B 1 105 LEU 105 105 105 LEU LEU B . n 
B 1 106 GLY 106 106 106 GLY GLY B . n 
B 1 107 GLN 107 107 107 GLN GLN B . n 
B 1 108 GLY 108 108 108 GLY GLY B . n 
B 1 109 TRP 109 109 109 TRP TRP B . n 
B 1 110 LEU 110 110 110 LEU LEU B . n 
B 1 111 THR 111 111 111 THR THR B . n 
B 1 112 ASP 112 112 112 ASP ASP B . n 
B 1 113 LYS 113 113 113 LYS LYS B . n 
B 1 114 VAL 114 114 114 VAL VAL B . n 
B 1 115 GLN 115 115 115 GLN GLN B . n 
B 1 116 GLU 116 116 116 GLU GLU B . n 
B 1 117 PHE 117 117 117 PHE PHE B . n 
B 1 118 LEU 118 118 118 LEU LEU B . n 
B 1 119 GLN 119 119 119 GLN GLN B . n 
B 1 120 LEU 120 120 120 LEU LEU B . n 
B 1 121 TYR 121 121 121 TYR TYR B . n 
B 1 122 PRO 122 122 122 PRO PRO B . n 
B 1 123 GLU 123 123 123 GLU GLU B . n 
B 1 124 MET 124 124 124 MET MET B . n 
B 1 125 SER 125 125 125 SER SER B . n 
B 1 126 ILE 126 126 126 ILE ILE B . n 
B 1 127 GLN 127 127 127 GLN GLN B . n 
B 1 128 LEU 128 128 128 LEU LEU B . n 
B 1 129 ILE 129 129 129 ILE ILE B . n 
B 1 130 LEU 130 130 130 LEU LEU B . n 
B 1 131 ASP 131 131 131 ASP ASP B . n 
B 1 132 ASN 132 132 132 ASN ASN B . n 
B 1 133 GLU 133 133 133 GLU GLU B . n 
B 1 134 GLU 134 134 134 GLU GLU B . n 
B 1 135 LEU 135 135 135 LEU LEU B . n 
B 1 136 ASP 136 136 136 ASP ASP B . n 
B 1 137 VAL 137 137 137 VAL VAL B . n 
B 1 138 ASN 138 138 138 ASN ASN B . n 
B 1 139 MET 139 139 139 MET MET B . n 
B 1 140 ARG 140 140 140 ARG ARG B . n 
B 1 141 HIS 141 141 141 HIS HIS B . n 
B 1 142 ALA 142 142 142 ALA ALA B . n 
B 1 143 ASP 143 143 143 ASP ASP B . n 
B 1 144 CYS 144 144 144 CYS CYS B . n 
B 1 145 ALA 145 145 145 ALA ALA B . n 
B 1 146 ILE 146 146 146 ILE ILE B . n 
B 1 147 ARG 147 147 147 ARG ARG B . n 
B 1 148 LEU 148 148 148 LEU LEU B . n 
B 1 149 ARG 149 149 149 ARG ARG B . n 
B 1 150 GLN 150 150 150 GLN GLN B . n 
B 1 151 PRO 151 151 151 PRO PRO B . n 
B 1 152 GLN 152 152 152 GLN GLN B . n 
B 1 153 GLN 153 153 153 GLN GLN B . n 
B 1 154 SER 154 154 154 SER SER B . n 
B 1 155 ASP 155 155 155 ASP ASP B . n 
B 1 156 LEU 156 156 156 LEU LEU B . n 
B 1 157 ILE 157 157 157 ILE ILE B . n 
B 1 158 GLN 158 158 158 GLN GLN B . n 
B 1 159 ARG 159 159 159 ARG ARG B . n 
B 1 160 LYS 160 160 160 LYS LYS B . n 
B 1 161 LEU 161 161 161 LEU LEU B . n 
B 1 162 PHE 162 162 162 PHE PHE B . n 
B 1 163 THR 163 163 163 THR THR B . n 
B 1 164 VAL 164 164 164 VAL VAL B . n 
B 1 165 HIS 165 165 165 HIS HIS B . n 
B 1 166 MET 166 166 166 MET MET B . n 
B 1 167 HIS 167 167 167 HIS HIS B . n 
B 1 168 VAL 168 168 168 VAL VAL B . n 
B 1 169 TYR 169 169 169 TYR TYR B . n 
B 1 170 ALA 170 170 170 ALA ALA B . n 
B 1 171 ALA 171 171 171 ALA ALA B . n 
B 1 172 PRO 172 172 172 PRO PRO B . n 
B 1 173 SER 173 173 173 SER SER B . n 
B 1 174 TYR 174 174 174 TYR TYR B . n 
B 1 175 ILE 175 175 175 ILE ILE B . n 
B 1 176 ASN 176 176 176 ASN ASN B . n 
B 1 177 ARG 177 177 177 ARG ARG B . n 
B 1 178 HIS 178 178 178 HIS HIS B . n 
B 1 179 GLY 179 179 179 GLY GLY B . n 
B 1 180 GLU 180 180 180 GLU GLU B . n 
B 1 181 PRO 181 181 181 PRO PRO B . n 
B 1 182 GLN 182 182 182 GLN GLN B . n 
B 1 183 SER 183 183 183 SER SER B . n 
B 1 184 VAL 184 184 184 VAL VAL B . n 
B 1 185 GLU 185 185 185 GLU GLU B . n 
B 1 186 ASP 186 186 186 ASP ASP B . n 
B 1 187 LEU 187 187 187 LEU LEU B . n 
B 1 188 ASP 188 188 188 ASP ASP B . n 
B 1 189 ASN 189 189 189 ASN ASN B . n 
B 1 190 HIS 190 190 190 HIS HIS B . n 
B 1 191 ARG 191 191 191 ARG ARG B . n 
B 1 192 ILE 192 192 192 ILE ILE B . n 
B 1 193 ILE 193 193 193 ILE ILE B . n 
B 1 194 SER 194 194 194 SER SER B . n 
B 1 195 PHE 195 195 195 PHE PHE B . n 
B 1 196 GLY 196 196 196 GLY GLY B . n 
B 1 197 GLU 197 197 197 GLU GLU B . n 
B 1 198 PRO 198 198 198 PRO PRO B . n 
B 1 199 ALA 199 199 199 ALA ALA B . n 
B 1 200 PRO 200 200 200 PRO PRO B . n 
B 1 201 ASN 201 201 201 ASN ASN B . n 
B 1 202 TYR 202 202 202 TYR TYR B . n 
B 1 203 LEU 203 203 203 LEU LEU B . n 
B 1 204 LEU 204 204 204 LEU LEU B . n 
B 1 205 ASP 205 205 205 ASP ASP B . n 
B 1 206 VAL 206 206 206 VAL VAL B . n 
B 1 207 ASN 207 207 207 ASN ASN B . n 
B 1 208 TRP 208 208 208 TRP TRP B . n 
B 1 209 LEU 209 209 209 LEU LEU B . n 
B 1 210 GLU 210 210 210 GLU GLU B . n 
B 1 211 ASN 211 211 211 ASN ASN B . n 
B 1 212 ALA 212 212 212 ALA ALA B . n 
B 1 213 GLY 213 213 213 GLY GLY B . n 
B 1 214 ARG 214 214 214 ARG ARG B . n 
B 1 215 SER 215 215 215 SER SER B . n 
B 1 216 SER 216 216 216 SER SER B . n 
B 1 217 ASP 217 217 217 ASP ASP B . n 
B 1 218 ASN 218 218 218 ASN ASN B . n 
B 1 219 THR 219 219 219 THR THR B . n 
B 1 220 ARG 220 220 220 ARG ARG B . n 
B 1 221 ILE 221 221 221 ILE ILE B . n 
B 1 222 PRO 222 222 222 PRO PRO B . n 
B 1 223 HIS 223 223 223 HIS HIS B . n 
B 1 224 LEU 224 224 224 LEU LEU B . n 
B 1 225 GLN 225 225 225 GLN GLN B . n 
B 1 226 ILE 226 226 226 ILE ILE B . n 
B 1 227 ASN 227 227 227 ASN ASN B . n 
B 1 228 SER 228 228 228 SER SER B . n 
B 1 229 GLN 229 229 229 GLN GLN B . n 
B 1 230 THR 230 230 230 THR THR B . n 
B 1 231 SER 231 231 231 SER SER B . n 
B 1 232 ILE 232 232 232 ILE ILE B . n 
B 1 233 LYS 233 233 233 LYS LYS B . n 
B 1 234 ARG 234 234 234 ARG ARG B . n 
B 1 235 ALA 235 235 235 ALA ALA B . n 
B 1 236 CYS 236 236 236 CYS CYS B . n 
B 1 237 LEU 237 237 237 LEU LEU B . n 
B 1 238 LEU 238 238 238 LEU LEU B . n 
B 1 239 GLY 239 239 239 GLY GLY B . n 
B 1 240 ILE 240 240 240 ILE ILE B . n 
B 1 241 GLY 241 241 241 GLY GLY B . n 
B 1 242 ILE 242 242 242 ILE ILE B . n 
B 1 243 ALA 243 243 243 ALA ALA B . n 
B 1 244 CYS 244 244 244 CYS CYS B . n 
B 1 245 LEU 245 245 245 LEU LEU B . n 
B 1 246 PRO 246 246 246 PRO PRO B . n 
B 1 247 ASP 247 247 247 ASP ASP B . n 
B 1 248 TYR 248 248 248 TYR TYR B . n 
B 1 249 ILE 249 249 249 ILE ILE B . n 
B 1 250 VAL 250 250 250 VAL VAL B . n 
B 1 251 GLY 251 251 251 GLY GLY B . n 
B 1 252 ARG 252 252 252 ARG ARG B . n 
B 1 253 ASP 253 253 253 ASP ASP B . n 
B 1 254 PRO 254 254 254 PRO PRO B . n 
B 1 255 GLY 255 255 255 GLY GLY B . n 
B 1 256 LEU 256 256 256 LEU LEU B . n 
B 1 257 ILE 257 257 257 ILE ILE B . n 
B 1 258 GLN 258 258 258 GLN GLN B . n 
B 1 259 LEU 259 259 259 LEU LEU B . n 
B 1 260 SER 260 260 260 SER SER B . n 
B 1 261 LEU 261 261 261 LEU LEU B . n 
B 1 262 ALA 262 262 262 ALA ALA B . n 
B 1 263 ALA 263 263 263 ALA ALA B . n 
B 1 264 ASP 264 264 264 ASP ASP B . n 
B 1 265 ILE 265 265 265 ILE ILE B . n 
B 1 266 PRO 266 266 266 PRO PRO B . n 
B 1 267 SER 267 267 267 SER SER B . n 
B 1 268 PHE 268 268 268 PHE PHE B . n 
B 1 269 ASP 269 269 269 ASP ASP B . n 
B 1 270 THR 270 270 270 THR THR B . n 
B 1 271 TYR 271 271 271 TYR TYR B . n 
B 1 272 PHE 272 272 272 PHE PHE B . n 
B 1 273 CYS 273 273 273 CYS CYS B . n 
B 1 274 TYR 274 274 274 TYR TYR B . n 
B 1 275 PRO 275 275 275 PRO PRO B . n 
B 1 276 ASP 276 276 276 ASP ASP B . n 
B 1 277 GLU 277 277 277 GLU GLU B . n 
B 1 278 MET 278 278 278 MET MET B . n 
B 1 279 LYS 279 279 279 LYS LYS B . n 
B 1 280 ASN 280 280 280 ASN ASN B . n 
B 1 281 ALA 281 281 281 ALA ALA B . n 
B 1 282 ALA 282 282 282 ALA ALA B . n 
B 1 283 LYS 283 283 283 LYS LYS B . n 
B 1 284 LEU 284 284 284 LEU LEU B . n 
B 1 285 LYS 285 285 285 LYS LYS B . n 
B 1 286 ALA 286 286 286 ALA ALA B . n 
B 1 287 PHE 287 287 287 PHE PHE B . n 
B 1 288 ARG 288 288 288 ARG ARG B . n 
B 1 289 ASP 289 289 289 ASP ASP B . n 
B 1 290 PHE 290 290 290 PHE PHE B . n 
B 1 291 ILE 291 291 291 ILE ILE B . n 
B 1 292 VAL 292 292 292 VAL VAL B . n 
B 1 293 ALA 293 293 293 ALA ALA B . n 
B 1 294 LYS 294 294 294 LYS LYS B . n 
B 1 295 ALA 295 295 295 ALA ALA B . n 
B 1 296 ARG 296 296 296 ARG ARG B . n 
B 1 297 ASN 297 297 297 ASN ASN B . n 
B 1 298 TRP 298 298 298 TRP TRP B . n 
B 1 299 ASN 299 299 299 ASN ASN B . n 
B 1 300 PHE 300 300 300 PHE PHE B . n 
B 1 301 GLY 301 301 ?   ?   ?   B . n 
B 1 302 THR 302 302 ?   ?   ?   B . n 
B 1 303 SER 303 303 ?   ?   ?   B . n 
B 1 304 ALA 304 304 ?   ?   ?   B . n 
B 1 305 TRP 305 305 ?   ?   ?   B . n 
B 1 306 SER 306 306 ?   ?   ?   B . n 
B 1 307 HIS 307 307 ?   ?   ?   B . n 
B 1 308 PRO 308 308 ?   ?   ?   B . n 
B 1 309 GLN 309 309 ?   ?   ?   B . n 
B 1 310 PHE 310 310 ?   ?   ?   B . n 
B 1 311 GLU 311 311 ?   ?   ?   B . n 
B 1 312 LYS 312 312 ?   ?   ?   B . n 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9HH1 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_struct.entry_id                     9HH1 
_struct.title                        'LysR Type Transcriptional Regulator LsrB from Agrobacterium tumefaciens' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9HH1 
_struct_keywords.text            
'LysR-type trancriptional regulator, DNA-Binding, Agrobacterium, transcription factor, DNA BINDING PROTEIN' 
_struct_keywords.pdbx_keywords   'DNA BINDING PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    A9CI74_AGRFC 
_struct_ref.pdbx_db_accession          A9CI74 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MAMPLDWDKLRIFHAAAEAGSFTHAADKLHLSQSAISRQVSALEQDVGVKLFHRHARGLILTEQGELLYRTAHDVLLKLE
TVKMQLTETTEKPSGKLRVTTTVGLGQGWLTDKVQEFLQLYPEMSIQLILDNEELDVNMRHADCAIRLRQPQQSDLIQRK
LFTVHMHVYAAPSYINRHGEPQSVEDLDNHRIISFGEPAPNYLLDVNWLENAGRSSDNTRIPHLQINSQTSIKRACLLGI
GIACLPDYIVGRDPGLIQLSLAADIPSFDTYFCYPDEMKNAAKLKAFRDFIVAKARNWNF
;
_struct_ref.pdbx_align_begin           1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9HH1 A 1 ? 300 ? A9CI74 1 ? 300 ? 1 300 
2 1 9HH1 B 1 ? 300 ? A9CI74 1 ? 300 ? 1 300 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9HH1 GLY A 301 ? UNP A9CI74 ? ? 'expression tag' 301 1  
1 9HH1 THR A 302 ? UNP A9CI74 ? ? 'expression tag' 302 2  
1 9HH1 SER A 303 ? UNP A9CI74 ? ? 'expression tag' 303 3  
1 9HH1 ALA A 304 ? UNP A9CI74 ? ? 'expression tag' 304 4  
1 9HH1 TRP A 305 ? UNP A9CI74 ? ? 'expression tag' 305 5  
1 9HH1 SER A 306 ? UNP A9CI74 ? ? 'expression tag' 306 6  
1 9HH1 HIS A 307 ? UNP A9CI74 ? ? 'expression tag' 307 7  
1 9HH1 PRO A 308 ? UNP A9CI74 ? ? 'expression tag' 308 8  
1 9HH1 GLN A 309 ? UNP A9CI74 ? ? 'expression tag' 309 9  
1 9HH1 PHE A 310 ? UNP A9CI74 ? ? 'expression tag' 310 10 
1 9HH1 GLU A 311 ? UNP A9CI74 ? ? 'expression tag' 311 11 
1 9HH1 LYS A 312 ? UNP A9CI74 ? ? 'expression tag' 312 12 
2 9HH1 GLY B 301 ? UNP A9CI74 ? ? 'expression tag' 301 13 
2 9HH1 THR B 302 ? UNP A9CI74 ? ? 'expression tag' 302 14 
2 9HH1 SER B 303 ? UNP A9CI74 ? ? 'expression tag' 303 15 
2 9HH1 ALA B 304 ? UNP A9CI74 ? ? 'expression tag' 304 16 
2 9HH1 TRP B 305 ? UNP A9CI74 ? ? 'expression tag' 305 17 
2 9HH1 SER B 306 ? UNP A9CI74 ? ? 'expression tag' 306 18 
2 9HH1 HIS B 307 ? UNP A9CI74 ? ? 'expression tag' 307 19 
2 9HH1 PRO B 308 ? UNP A9CI74 ? ? 'expression tag' 308 20 
2 9HH1 GLN B 309 ? UNP A9CI74 ? ? 'expression tag' 309 21 
2 9HH1 PHE B 310 ? UNP A9CI74 ? ? 'expression tag' 310 22 
2 9HH1 GLU B 311 ? UNP A9CI74 ? ? 'expression tag' 311 23 
2 9HH1 LYS B 312 ? UNP A9CI74 ? ? 'expression tag' 312 24 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0 
_pdbx_struct_oper_list.matrix[1][2]         0.0 
_pdbx_struct_oper_list.matrix[1][3]         0.0 
_pdbx_struct_oper_list.vector[1]            0.0 
_pdbx_struct_oper_list.matrix[2][1]         0.0 
_pdbx_struct_oper_list.matrix[2][2]         1.0 
_pdbx_struct_oper_list.matrix[2][3]         0.0 
_pdbx_struct_oper_list.vector[2]            0.0 
_pdbx_struct_oper_list.matrix[3][1]         0.0 
_pdbx_struct_oper_list.matrix[3][2]         0.0 
_pdbx_struct_oper_list.matrix[3][3]         1.0 
_pdbx_struct_oper_list.vector[3]            0.0 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 THR A 102 ? TRP A 109 ? THR A 102 TRP A 109 1 ? 8  
HELX_P HELX_P2  AA2 TRP A 109 ? TYR A 121 ? TRP A 109 TYR A 121 1 ? 13 
HELX_P HELX_P3  AA3 ALA A 171 ? GLY A 179 ? ALA A 171 GLY A 179 1 ? 9  
HELX_P HELX_P4  AA4 VAL A 184 ? HIS A 190 ? VAL A 184 HIS A 190 5 ? 7  
HELX_P HELX_P5  AA5 ASN A 207 ? ALA A 212 ? ASN A 207 ALA A 212 1 ? 6  
HELX_P HELX_P6  AA6 SER A 228 ? LEU A 238 ? SER A 228 LEU A 238 1 ? 11 
HELX_P HELX_P7  AA7 ASP A 247 ? GLY A 251 ? ASP A 247 GLY A 251 1 ? 5  
HELX_P HELX_P8  AA8 GLU A 277 ? LYS A 279 ? GLU A 277 LYS A 279 5 ? 3  
HELX_P HELX_P9  AA9 ALA A 281 ? ASN A 297 ? ALA A 281 ASN A 297 1 ? 17 
HELX_P HELX_P10 AB1 THR B 102 ? TRP B 109 ? THR B 102 TRP B 109 1 ? 8  
HELX_P HELX_P11 AB2 TRP B 109 ? TYR B 121 ? TRP B 109 TYR B 121 1 ? 13 
HELX_P HELX_P12 AB3 ALA B 171 ? GLY B 179 ? ALA B 171 GLY B 179 1 ? 9  
HELX_P HELX_P13 AB4 VAL B 184 ? HIS B 190 ? VAL B 184 HIS B 190 5 ? 7  
HELX_P HELX_P14 AB5 ASN B 207 ? ALA B 212 ? ASN B 207 ALA B 212 1 ? 6  
HELX_P HELX_P15 AB6 SER B 228 ? LEU B 238 ? SER B 228 LEU B 238 1 ? 11 
HELX_P HELX_P16 AB7 ASP B 247 ? GLY B 251 ? ASP B 247 GLY B 251 1 ? 5  
HELX_P HELX_P17 AB8 GLU B 277 ? LYS B 279 ? GLU B 277 LYS B 279 5 ? 3  
HELX_P HELX_P18 AB9 ALA B 281 ? ASN B 297 ? ALA B 281 ASN B 297 1 ? 17 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 GLU 197 A . ? GLU 197 A PRO 198 A ? PRO 198 A 1 -1.00 
2 GLU 197 B . ? GLU 197 B PRO 198 B ? PRO 198 B 1 -1.37 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 10 ? 
AA2 ? 10 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2  ? anti-parallel 
AA1 2 3  ? anti-parallel 
AA1 3 4  ? parallel      
AA1 4 5  ? parallel      
AA1 5 6  ? parallel      
AA1 6 7  ? parallel      
AA1 7 8  ? parallel      
AA1 8 9  ? anti-parallel 
AA1 9 10 ? anti-parallel 
AA2 1 2  ? anti-parallel 
AA2 2 3  ? anti-parallel 
AA2 3 4  ? parallel      
AA2 4 5  ? parallel      
AA2 5 6  ? parallel      
AA2 6 7  ? parallel      
AA2 7 8  ? parallel      
AA2 8 9  ? anti-parallel 
AA2 9 10 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1  LEU A 156 ? VAL A 164 ? LEU A 156 VAL A 164 
AA1 2  PHE A 268 ? PRO A 275 ? PHE A 268 PRO A 275 
AA1 3  CYS A 144 ? ARG A 147 ? CYS A 144 ARG A 147 
AA1 4  LYS A 96  ? THR A 101 ? LYS A 96  THR A 101 
AA1 5  SER A 125 ? LEU A 130 ? SER A 125 LEU A 130 
AA1 6  LEU B 224 ? ILE B 226 ? LEU B 224 ILE B 226 
AA1 7  ILE B 192 ? SER B 194 ? ILE B 192 SER B 194 
AA1 8  ILE B 242 ? PRO B 246 ? ILE B 242 PRO B 246 
AA1 9  MET B 166 ? ALA B 170 ? MET B 166 ALA B 170 
AA1 10 ILE B 257 ? LEU B 259 ? ILE B 257 LEU B 259 
AA2 1  ILE A 257 ? LEU A 259 ? ILE A 257 LEU A 259 
AA2 2  MET A 166 ? ALA A 170 ? MET A 166 ALA A 170 
AA2 3  ILE A 242 ? PRO A 246 ? ILE A 242 PRO A 246 
AA2 4  ILE A 192 ? SER A 194 ? ILE A 192 SER A 194 
AA2 5  LEU A 224 ? ILE A 226 ? LEU A 224 ILE A 226 
AA2 6  SER B 125 ? LEU B 130 ? SER B 125 LEU B 130 
AA2 7  LYS B 96  ? THR B 101 ? LYS B 96  THR B 101 
AA2 8  CYS B 144 ? ARG B 147 ? CYS B 144 ARG B 147 
AA2 9  PHE B 268 ? PRO B 275 ? PHE B 268 PRO B 275 
AA2 10 LEU B 156 ? VAL B 164 ? LEU B 156 VAL B 164 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2  N VAL A 164 ? N VAL A 164 O PHE A 268 ? O PHE A 268 
AA1 2 3  O TYR A 271 ? O TYR A 271 N ARG A 147 ? N ARG A 147 
AA1 3 4  O CYS A 144 ? O CYS A 144 N THR A 100 ? N THR A 100 
AA1 4 5  N VAL A 99  ? N VAL A 99  O GLN A 127 ? O GLN A 127 
AA1 5 6  N LEU A 128 ? N LEU A 128 O GLN B 225 ? O GLN B 225 
AA1 6 7  O ILE B 226 ? O ILE B 226 N SER B 194 ? N SER B 194 
AA1 7 8  N ILE B 193 ? N ILE B 193 O ILE B 242 ? O ILE B 242 
AA1 8 9  O ALA B 243 ? O ALA B 243 N TYR B 169 ? N TYR B 169 
AA1 9 10 N ALA B 170 ? N ALA B 170 O ILE B 257 ? O ILE B 257 
AA2 1 2  O ILE A 257 ? O ILE A 257 N ALA A 170 ? N ALA A 170 
AA2 2 3  N TYR A 169 ? N TYR A 169 O ALA A 243 ? O ALA A 243 
AA2 3 4  O ILE A 242 ? O ILE A 242 N ILE A 193 ? N ILE A 193 
AA2 4 5  N SER A 194 ? N SER A 194 O ILE A 226 ? O ILE A 226 
AA2 5 6  N GLN A 225 ? N GLN A 225 O LEU B 128 ? O LEU B 128 
AA2 6 7  O GLN B 127 ? O GLN B 127 N VAL B 99  ? N VAL B 99  
AA2 7 8  N THR B 100 ? N THR B 100 O CYS B 144 ? O CYS B 144 
AA2 8 9  N ARG B 147 ? N ARG B 147 O TYR B 271 ? O TYR B 271 
AA2 9 10 O PHE B 268 ? O PHE B 268 N VAL B 164 ? N VAL B 164 
# 
_pdbx_entry_details.entry_id                   9HH1 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 NE1 B TRP 298 ? ? CE2 B PHE 300 ? ? 1.89 
2 1 CE2 A TRP 298 ? ? CE2 A PHE 300 ? ? 1.89 
3 1 NE1 A TRP 298 ? ? CE2 A PHE 300 ? ? 1.93 
4 1 CE2 B TRP 298 ? ? CE2 B PHE 300 ? ? 1.99 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 TRP A 109 ? ? -132.26 -50.08 
2 1 LEU A 161 ? ? -97.42  -85.39 
3 1 ASP A 205 ? ? 59.43   17.15  
4 1 ASN A 227 ? ? -74.92  43.81  
5 1 TRP B 109 ? ? -132.09 -50.14 
6 1 LEU B 161 ? ? -97.85  -85.91 
7 1 ASN B 227 ? ? -74.32  43.50  
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9HH1 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         REAL 
_em_3d_fitting.ref_protocol      'AB INITIO MODEL' 
# 
_em_3d_fitting_list.id                            1 
_em_3d_fitting_list.3d_fitting_id                 1 
_em_3d_fitting_list.pdb_entry_id                  . 
_em_3d_fitting_list.pdb_chain_id                  . 
_em_3d_fitting_list.pdb_chain_residue_range       . 
_em_3d_fitting_list.details                       ? 
_em_3d_fitting_list.chain_id                      ? 
_em_3d_fitting_list.chain_residue_range           ? 
_em_3d_fitting_list.source_name                   AlphaFold 
_em_3d_fitting_list.type                          'in silico model' 
_em_3d_fitting_list.accession_code                ? 
_em_3d_fitting_list.initial_refinement_model_id   ? 
# 
_em_3d_reconstruction.entry_id                    9HH1 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   'FOURIER SPACE' 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.9 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               484971 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          1 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            8 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 'ORGANELLE OR CELLULAR COMPONENT' 
_em_entity_assembly.name                 'Dimeric LTTR-type transcriptional regulator LsrB' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1 
# 
_em_imaging.entry_id                        9HH1 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'TFS KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           'FEI TITAN KRIOS AUTOGRID HOLDER' 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             800 
_em_imaging.nominal_defocus_max             2800 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         NITROGEN 
# 
_em_sample_support.id               1 
_em_sample_support.film_material    ? 
_em_sample_support.method           ? 
_em_sample_support.grid_material    COPPER 
_em_sample_support.grid_mesh_size   200 
_em_sample_support.grid_type        'Quantifoil R1.2/1.3' 
_em_sample_support.details          15mA 
_em_sample_support.specimen_id      1 
_em_sample_support.citation_id      ? 
# 
_em_vitrification.entry_id              9HH1 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              95 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   277.15 
_em_vitrification.instrument            'FEI VITROBOT MARK IV' 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                9HH1 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
_em_single_particle_entity.entry_id              9HH1 
_em_single_particle_entity.id                    1 
_em_single_particle_entity.image_processing_id   1 
_em_single_particle_entity.point_symmetry        C2 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A MET 1   ? A MET 1   
2   1 Y 1 A ALA 2   ? A ALA 2   
3   1 Y 1 A MET 3   ? A MET 3   
4   1 Y 1 A PRO 4   ? A PRO 4   
5   1 Y 1 A LEU 5   ? A LEU 5   
6   1 Y 1 A ASP 6   ? A ASP 6   
7   1 Y 1 A TRP 7   ? A TRP 7   
8   1 Y 1 A ASP 8   ? A ASP 8   
9   1 Y 1 A LYS 9   ? A LYS 9   
10  1 Y 1 A LEU 10  ? A LEU 10  
11  1 Y 1 A ARG 11  ? A ARG 11  
12  1 Y 1 A ILE 12  ? A ILE 12  
13  1 Y 1 A PHE 13  ? A PHE 13  
14  1 Y 1 A HIS 14  ? A HIS 14  
15  1 Y 1 A ALA 15  ? A ALA 15  
16  1 Y 1 A ALA 16  ? A ALA 16  
17  1 Y 1 A ALA 17  ? A ALA 17  
18  1 Y 1 A GLU 18  ? A GLU 18  
19  1 Y 1 A ALA 19  ? A ALA 19  
20  1 Y 1 A GLY 20  ? A GLY 20  
21  1 Y 1 A SER 21  ? A SER 21  
22  1 Y 1 A PHE 22  ? A PHE 22  
23  1 Y 1 A THR 23  ? A THR 23  
24  1 Y 1 A HIS 24  ? A HIS 24  
25  1 Y 1 A ALA 25  ? A ALA 25  
26  1 Y 1 A ALA 26  ? A ALA 26  
27  1 Y 1 A ASP 27  ? A ASP 27  
28  1 Y 1 A LYS 28  ? A LYS 28  
29  1 Y 1 A LEU 29  ? A LEU 29  
30  1 Y 1 A HIS 30  ? A HIS 30  
31  1 Y 1 A LEU 31  ? A LEU 31  
32  1 Y 1 A SER 32  ? A SER 32  
33  1 Y 1 A GLN 33  ? A GLN 33  
34  1 Y 1 A SER 34  ? A SER 34  
35  1 Y 1 A ALA 35  ? A ALA 35  
36  1 Y 1 A ILE 36  ? A ILE 36  
37  1 Y 1 A SER 37  ? A SER 37  
38  1 Y 1 A ARG 38  ? A ARG 38  
39  1 Y 1 A GLN 39  ? A GLN 39  
40  1 Y 1 A VAL 40  ? A VAL 40  
41  1 Y 1 A SER 41  ? A SER 41  
42  1 Y 1 A ALA 42  ? A ALA 42  
43  1 Y 1 A LEU 43  ? A LEU 43  
44  1 Y 1 A GLU 44  ? A GLU 44  
45  1 Y 1 A GLN 45  ? A GLN 45  
46  1 Y 1 A ASP 46  ? A ASP 46  
47  1 Y 1 A VAL 47  ? A VAL 47  
48  1 Y 1 A GLY 48  ? A GLY 48  
49  1 Y 1 A VAL 49  ? A VAL 49  
50  1 Y 1 A LYS 50  ? A LYS 50  
51  1 Y 1 A LEU 51  ? A LEU 51  
52  1 Y 1 A PHE 52  ? A PHE 52  
53  1 Y 1 A HIS 53  ? A HIS 53  
54  1 Y 1 A ARG 54  ? A ARG 54  
55  1 Y 1 A HIS 55  ? A HIS 55  
56  1 Y 1 A ALA 56  ? A ALA 56  
57  1 Y 1 A ARG 57  ? A ARG 57  
58  1 Y 1 A GLY 58  ? A GLY 58  
59  1 Y 1 A LEU 59  ? A LEU 59  
60  1 Y 1 A ILE 60  ? A ILE 60  
61  1 Y 1 A LEU 61  ? A LEU 61  
62  1 Y 1 A THR 62  ? A THR 62  
63  1 Y 1 A GLU 63  ? A GLU 63  
64  1 Y 1 A GLN 64  ? A GLN 64  
65  1 Y 1 A GLY 65  ? A GLY 65  
66  1 Y 1 A GLU 66  ? A GLU 66  
67  1 Y 1 A LEU 67  ? A LEU 67  
68  1 Y 1 A LEU 68  ? A LEU 68  
69  1 Y 1 A TYR 69  ? A TYR 69  
70  1 Y 1 A ARG 70  ? A ARG 70  
71  1 Y 1 A THR 71  ? A THR 71  
72  1 Y 1 A ALA 72  ? A ALA 72  
73  1 Y 1 A HIS 73  ? A HIS 73  
74  1 Y 1 A ASP 74  ? A ASP 74  
75  1 Y 1 A VAL 75  ? A VAL 75  
76  1 Y 1 A LEU 76  ? A LEU 76  
77  1 Y 1 A LEU 77  ? A LEU 77  
78  1 Y 1 A LYS 78  ? A LYS 78  
79  1 Y 1 A LEU 79  ? A LEU 79  
80  1 Y 1 A GLU 80  ? A GLU 80  
81  1 Y 1 A THR 81  ? A THR 81  
82  1 Y 1 A VAL 82  ? A VAL 82  
83  1 Y 1 A LYS 83  ? A LYS 83  
84  1 Y 1 A MET 84  ? A MET 84  
85  1 Y 1 A GLN 85  ? A GLN 85  
86  1 Y 1 A LEU 86  ? A LEU 86  
87  1 Y 1 A THR 87  ? A THR 87  
88  1 Y 1 A GLU 88  ? A GLU 88  
89  1 Y 1 A THR 89  ? A THR 89  
90  1 Y 1 A THR 90  ? A THR 90  
91  1 Y 1 A GLU 91  ? A GLU 91  
92  1 Y 1 A LYS 92  ? A LYS 92  
93  1 Y 1 A PRO 93  ? A PRO 93  
94  1 Y 1 A SER 94  ? A SER 94  
95  1 Y 1 A GLY 301 ? A GLY 301 
96  1 Y 1 A THR 302 ? A THR 302 
97  1 Y 1 A SER 303 ? A SER 303 
98  1 Y 1 A ALA 304 ? A ALA 304 
99  1 Y 1 A TRP 305 ? A TRP 305 
100 1 Y 1 A SER 306 ? A SER 306 
101 1 Y 1 A HIS 307 ? A HIS 307 
102 1 Y 1 A PRO 308 ? A PRO 308 
103 1 Y 1 A GLN 309 ? A GLN 309 
104 1 Y 1 A PHE 310 ? A PHE 310 
105 1 Y 1 A GLU 311 ? A GLU 311 
106 1 Y 1 A LYS 312 ? A LYS 312 
107 1 Y 1 B MET 1   ? B MET 1   
108 1 Y 1 B ALA 2   ? B ALA 2   
109 1 Y 1 B MET 3   ? B MET 3   
110 1 Y 1 B PRO 4   ? B PRO 4   
111 1 Y 1 B LEU 5   ? B LEU 5   
112 1 Y 1 B ASP 6   ? B ASP 6   
113 1 Y 1 B TRP 7   ? B TRP 7   
114 1 Y 1 B ASP 8   ? B ASP 8   
115 1 Y 1 B LYS 9   ? B LYS 9   
116 1 Y 1 B LEU 10  ? B LEU 10  
117 1 Y 1 B ARG 11  ? B ARG 11  
118 1 Y 1 B ILE 12  ? B ILE 12  
119 1 Y 1 B PHE 13  ? B PHE 13  
120 1 Y 1 B HIS 14  ? B HIS 14  
121 1 Y 1 B ALA 15  ? B ALA 15  
122 1 Y 1 B ALA 16  ? B ALA 16  
123 1 Y 1 B ALA 17  ? B ALA 17  
124 1 Y 1 B GLU 18  ? B GLU 18  
125 1 Y 1 B ALA 19  ? B ALA 19  
126 1 Y 1 B GLY 20  ? B GLY 20  
127 1 Y 1 B SER 21  ? B SER 21  
128 1 Y 1 B PHE 22  ? B PHE 22  
129 1 Y 1 B THR 23  ? B THR 23  
130 1 Y 1 B HIS 24  ? B HIS 24  
131 1 Y 1 B ALA 25  ? B ALA 25  
132 1 Y 1 B ALA 26  ? B ALA 26  
133 1 Y 1 B ASP 27  ? B ASP 27  
134 1 Y 1 B LYS 28  ? B LYS 28  
135 1 Y 1 B LEU 29  ? B LEU 29  
136 1 Y 1 B HIS 30  ? B HIS 30  
137 1 Y 1 B LEU 31  ? B LEU 31  
138 1 Y 1 B SER 32  ? B SER 32  
139 1 Y 1 B GLN 33  ? B GLN 33  
140 1 Y 1 B SER 34  ? B SER 34  
141 1 Y 1 B ALA 35  ? B ALA 35  
142 1 Y 1 B ILE 36  ? B ILE 36  
143 1 Y 1 B SER 37  ? B SER 37  
144 1 Y 1 B ARG 38  ? B ARG 38  
145 1 Y 1 B GLN 39  ? B GLN 39  
146 1 Y 1 B VAL 40  ? B VAL 40  
147 1 Y 1 B SER 41  ? B SER 41  
148 1 Y 1 B ALA 42  ? B ALA 42  
149 1 Y 1 B LEU 43  ? B LEU 43  
150 1 Y 1 B GLU 44  ? B GLU 44  
151 1 Y 1 B GLN 45  ? B GLN 45  
152 1 Y 1 B ASP 46  ? B ASP 46  
153 1 Y 1 B VAL 47  ? B VAL 47  
154 1 Y 1 B GLY 48  ? B GLY 48  
155 1 Y 1 B VAL 49  ? B VAL 49  
156 1 Y 1 B LYS 50  ? B LYS 50  
157 1 Y 1 B LEU 51  ? B LEU 51  
158 1 Y 1 B PHE 52  ? B PHE 52  
159 1 Y 1 B HIS 53  ? B HIS 53  
160 1 Y 1 B ARG 54  ? B ARG 54  
161 1 Y 1 B HIS 55  ? B HIS 55  
162 1 Y 1 B ALA 56  ? B ALA 56  
163 1 Y 1 B ARG 57  ? B ARG 57  
164 1 Y 1 B GLY 58  ? B GLY 58  
165 1 Y 1 B LEU 59  ? B LEU 59  
166 1 Y 1 B ILE 60  ? B ILE 60  
167 1 Y 1 B LEU 61  ? B LEU 61  
168 1 Y 1 B THR 62  ? B THR 62  
169 1 Y 1 B GLU 63  ? B GLU 63  
170 1 Y 1 B GLN 64  ? B GLN 64  
171 1 Y 1 B GLY 65  ? B GLY 65  
172 1 Y 1 B GLU 66  ? B GLU 66  
173 1 Y 1 B LEU 67  ? B LEU 67  
174 1 Y 1 B LEU 68  ? B LEU 68  
175 1 Y 1 B TYR 69  ? B TYR 69  
176 1 Y 1 B ARG 70  ? B ARG 70  
177 1 Y 1 B THR 71  ? B THR 71  
178 1 Y 1 B ALA 72  ? B ALA 72  
179 1 Y 1 B HIS 73  ? B HIS 73  
180 1 Y 1 B ASP 74  ? B ASP 74  
181 1 Y 1 B VAL 75  ? B VAL 75  
182 1 Y 1 B LEU 76  ? B LEU 76  
183 1 Y 1 B LEU 77  ? B LEU 77  
184 1 Y 1 B LYS 78  ? B LYS 78  
185 1 Y 1 B LEU 79  ? B LEU 79  
186 1 Y 1 B GLU 80  ? B GLU 80  
187 1 Y 1 B THR 81  ? B THR 81  
188 1 Y 1 B VAL 82  ? B VAL 82  
189 1 Y 1 B LYS 83  ? B LYS 83  
190 1 Y 1 B MET 84  ? B MET 84  
191 1 Y 1 B GLN 85  ? B GLN 85  
192 1 Y 1 B LEU 86  ? B LEU 86  
193 1 Y 1 B THR 87  ? B THR 87  
194 1 Y 1 B GLU 88  ? B GLU 88  
195 1 Y 1 B THR 89  ? B THR 89  
196 1 Y 1 B THR 90  ? B THR 90  
197 1 Y 1 B GLU 91  ? B GLU 91  
198 1 Y 1 B LYS 92  ? B LYS 92  
199 1 Y 1 B PRO 93  ? B PRO 93  
200 1 Y 1 B SER 94  ? B SER 94  
201 1 Y 1 B GLY 301 ? B GLY 301 
202 1 Y 1 B THR 302 ? B THR 302 
203 1 Y 1 B SER 303 ? B SER 303 
204 1 Y 1 B ALA 304 ? B ALA 304 
205 1 Y 1 B TRP 305 ? B TRP 305 
206 1 Y 1 B SER 306 ? B SER 306 
207 1 Y 1 B HIS 307 ? B HIS 307 
208 1 Y 1 B PRO 308 ? B PRO 308 
209 1 Y 1 B GLN 309 ? B GLN 309 
210 1 Y 1 B PHE 310 ? B PHE 310 
211 1 Y 1 B GLU 311 ? B GLU 311 
212 1 Y 1 B LYS 312 ? B LYS 312 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
PHE N    N N N 247 
PHE CA   C N S 248 
PHE C    C N N 249 
PHE O    O N N 250 
PHE CB   C N N 251 
PHE CG   C Y N 252 
PHE CD1  C Y N 253 
PHE CD2  C Y N 254 
PHE CE1  C Y N 255 
PHE CE2  C Y N 256 
PHE CZ   C Y N 257 
PHE OXT  O N N 258 
PHE H    H N N 259 
PHE H2   H N N 260 
PHE HA   H N N 261 
PHE HB2  H N N 262 
PHE HB3  H N N 263 
PHE HD1  H N N 264 
PHE HD2  H N N 265 
PHE HE1  H N N 266 
PHE HE2  H N N 267 
PHE HZ   H N N 268 
PHE HXT  H N N 269 
PRO N    N N N 270 
PRO CA   C N S 271 
PRO C    C N N 272 
PRO O    O N N 273 
PRO CB   C N N 274 
PRO CG   C N N 275 
PRO CD   C N N 276 
PRO OXT  O N N 277 
PRO H    H N N 278 
PRO HA   H N N 279 
PRO HB2  H N N 280 
PRO HB3  H N N 281 
PRO HG2  H N N 282 
PRO HG3  H N N 283 
PRO HD2  H N N 284 
PRO HD3  H N N 285 
PRO HXT  H N N 286 
SER N    N N N 287 
SER CA   C N S 288 
SER C    C N N 289 
SER O    O N N 290 
SER CB   C N N 291 
SER OG   O N N 292 
SER OXT  O N N 293 
SER H    H N N 294 
SER H2   H N N 295 
SER HA   H N N 296 
SER HB2  H N N 297 
SER HB3  H N N 298 
SER HG   H N N 299 
SER HXT  H N N 300 
THR N    N N N 301 
THR CA   C N S 302 
THR C    C N N 303 
THR O    O N N 304 
THR CB   C N R 305 
THR OG1  O N N 306 
THR CG2  C N N 307 
THR OXT  O N N 308 
THR H    H N N 309 
THR H2   H N N 310 
THR HA   H N N 311 
THR HB   H N N 312 
THR HG1  H N N 313 
THR HG21 H N N 314 
THR HG22 H N N 315 
THR HG23 H N N 316 
THR HXT  H N N 317 
TRP N    N N N 318 
TRP CA   C N S 319 
TRP C    C N N 320 
TRP O    O N N 321 
TRP CB   C N N 322 
TRP CG   C Y N 323 
TRP CD1  C Y N 324 
TRP CD2  C Y N 325 
TRP NE1  N Y N 326 
TRP CE2  C Y N 327 
TRP CE3  C Y N 328 
TRP CZ2  C Y N 329 
TRP CZ3  C Y N 330 
TRP CH2  C Y N 331 
TRP OXT  O N N 332 
TRP H    H N N 333 
TRP H2   H N N 334 
TRP HA   H N N 335 
TRP HB2  H N N 336 
TRP HB3  H N N 337 
TRP HD1  H N N 338 
TRP HE1  H N N 339 
TRP HE3  H N N 340 
TRP HZ2  H N N 341 
TRP HZ3  H N N 342 
TRP HH2  H N N 343 
TRP HXT  H N N 344 
TYR N    N N N 345 
TYR CA   C N S 346 
TYR C    C N N 347 
TYR O    O N N 348 
TYR CB   C N N 349 
TYR CG   C Y N 350 
TYR CD1  C Y N 351 
TYR CD2  C Y N 352 
TYR CE1  C Y N 353 
TYR CE2  C Y N 354 
TYR CZ   C Y N 355 
TYR OH   O N N 356 
TYR OXT  O N N 357 
TYR H    H N N 358 
TYR H2   H N N 359 
TYR HA   H N N 360 
TYR HB2  H N N 361 
TYR HB3  H N N 362 
TYR HD1  H N N 363 
TYR HD2  H N N 364 
TYR HE1  H N N 365 
TYR HE2  H N N 366 
TYR HH   H N N 367 
TYR HXT  H N N 368 
VAL N    N N N 369 
VAL CA   C N S 370 
VAL C    C N N 371 
VAL O    O N N 372 
VAL CB   C N N 373 
VAL CG1  C N N 374 
VAL CG2  C N N 375 
VAL OXT  O N N 376 
VAL H    H N N 377 
VAL H2   H N N 378 
VAL HA   H N N 379 
VAL HB   H N N 380 
VAL HG11 H N N 381 
VAL HG12 H N N 382 
VAL HG13 H N N 383 
VAL HG21 H N N 384 
VAL HG22 H N N 385 
VAL HG23 H N N 386 
VAL HXT  H N N 387 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
PHE N   CA   sing N N 235 
PHE N   H    sing N N 236 
PHE N   H2   sing N N 237 
PHE CA  C    sing N N 238 
PHE CA  CB   sing N N 239 
PHE CA  HA   sing N N 240 
PHE C   O    doub N N 241 
PHE C   OXT  sing N N 242 
PHE CB  CG   sing N N 243 
PHE CB  HB2  sing N N 244 
PHE CB  HB3  sing N N 245 
PHE CG  CD1  doub Y N 246 
PHE CG  CD2  sing Y N 247 
PHE CD1 CE1  sing Y N 248 
PHE CD1 HD1  sing N N 249 
PHE CD2 CE2  doub Y N 250 
PHE CD2 HD2  sing N N 251 
PHE CE1 CZ   doub Y N 252 
PHE CE1 HE1  sing N N 253 
PHE CE2 CZ   sing Y N 254 
PHE CE2 HE2  sing N N 255 
PHE CZ  HZ   sing N N 256 
PHE OXT HXT  sing N N 257 
PRO N   CA   sing N N 258 
PRO N   CD   sing N N 259 
PRO N   H    sing N N 260 
PRO CA  C    sing N N 261 
PRO CA  CB   sing N N 262 
PRO CA  HA   sing N N 263 
PRO C   O    doub N N 264 
PRO C   OXT  sing N N 265 
PRO CB  CG   sing N N 266 
PRO CB  HB2  sing N N 267 
PRO CB  HB3  sing N N 268 
PRO CG  CD   sing N N 269 
PRO CG  HG2  sing N N 270 
PRO CG  HG3  sing N N 271 
PRO CD  HD2  sing N N 272 
PRO CD  HD3  sing N N 273 
PRO OXT HXT  sing N N 274 
SER N   CA   sing N N 275 
SER N   H    sing N N 276 
SER N   H2   sing N N 277 
SER CA  C    sing N N 278 
SER CA  CB   sing N N 279 
SER CA  HA   sing N N 280 
SER C   O    doub N N 281 
SER C   OXT  sing N N 282 
SER CB  OG   sing N N 283 
SER CB  HB2  sing N N 284 
SER CB  HB3  sing N N 285 
SER OG  HG   sing N N 286 
SER OXT HXT  sing N N 287 
THR N   CA   sing N N 288 
THR N   H    sing N N 289 
THR N   H2   sing N N 290 
THR CA  C    sing N N 291 
THR CA  CB   sing N N 292 
THR CA  HA   sing N N 293 
THR C   O    doub N N 294 
THR C   OXT  sing N N 295 
THR CB  OG1  sing N N 296 
THR CB  CG2  sing N N 297 
THR CB  HB   sing N N 298 
THR OG1 HG1  sing N N 299 
THR CG2 HG21 sing N N 300 
THR CG2 HG22 sing N N 301 
THR CG2 HG23 sing N N 302 
THR OXT HXT  sing N N 303 
TRP N   CA   sing N N 304 
TRP N   H    sing N N 305 
TRP N   H2   sing N N 306 
TRP CA  C    sing N N 307 
TRP CA  CB   sing N N 308 
TRP CA  HA   sing N N 309 
TRP C   O    doub N N 310 
TRP C   OXT  sing N N 311 
TRP CB  CG   sing N N 312 
TRP CB  HB2  sing N N 313 
TRP CB  HB3  sing N N 314 
TRP CG  CD1  doub Y N 315 
TRP CG  CD2  sing Y N 316 
TRP CD1 NE1  sing Y N 317 
TRP CD1 HD1  sing N N 318 
TRP CD2 CE2  doub Y N 319 
TRP CD2 CE3  sing Y N 320 
TRP NE1 CE2  sing Y N 321 
TRP NE1 HE1  sing N N 322 
TRP CE2 CZ2  sing Y N 323 
TRP CE3 CZ3  doub Y N 324 
TRP CE3 HE3  sing N N 325 
TRP CZ2 CH2  doub Y N 326 
TRP CZ2 HZ2  sing N N 327 
TRP CZ3 CH2  sing Y N 328 
TRP CZ3 HZ3  sing N N 329 
TRP CH2 HH2  sing N N 330 
TRP OXT HXT  sing N N 331 
TYR N   CA   sing N N 332 
TYR N   H    sing N N 333 
TYR N   H2   sing N N 334 
TYR CA  C    sing N N 335 
TYR CA  CB   sing N N 336 
TYR CA  HA   sing N N 337 
TYR C   O    doub N N 338 
TYR C   OXT  sing N N 339 
TYR CB  CG   sing N N 340 
TYR CB  HB2  sing N N 341 
TYR CB  HB3  sing N N 342 
TYR CG  CD1  doub Y N 343 
TYR CG  CD2  sing Y N 344 
TYR CD1 CE1  sing Y N 345 
TYR CD1 HD1  sing N N 346 
TYR CD2 CE2  doub Y N 347 
TYR CD2 HD2  sing N N 348 
TYR CE1 CZ   doub Y N 349 
TYR CE1 HE1  sing N N 350 
TYR CE2 CZ   sing Y N 351 
TYR CE2 HE2  sing N N 352 
TYR CZ  OH   sing N N 353 
TYR OH  HH   sing N N 354 
TYR OXT HXT  sing N N 355 
VAL N   CA   sing N N 356 
VAL N   H    sing N N 357 
VAL N   H2   sing N N 358 
VAL CA  C    sing N N 359 
VAL CA  CB   sing N N 360 
VAL CA  HA   sing N N 361 
VAL C   O    doub N N 362 
VAL C   OXT  sing N N 363 
VAL CB  CG1  sing N N 364 
VAL CB  CG2  sing N N 365 
VAL CB  HB   sing N N 366 
VAL CG1 HG11 sing N N 367 
VAL CG1 HG12 sing N N 368 
VAL CG1 HG13 sing N N 369 
VAL CG2 HG21 sing N N 370 
VAL CG2 HG22 sing N N 371 
VAL CG2 HG23 sing N N 372 
VAL OXT HXT  sing N N 373 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-11-20 
_em_admin.deposition_site    PDBE 
_em_admin.entry_id           9HH1 
_em_admin.last_update        2025-04-16 
_em_admin.map_release_date   2025-04-16 
_em_admin.title              'LysR Type Transcriptional Regulator LsrB from Agrobacterium tumefaciens' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     NONE 
# 
_em_entity_assembly_molwt.entity_assembly_id   1 
_em_entity_assembly_molwt.experimental_flag    YES 
_em_entity_assembly_molwt.id                   1 
_em_entity_assembly_molwt.units                MEGADALTONS 
_em_entity_assembly_molwt.value                0.076 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          358 
_em_entity_assembly_naturalsource.organism             'Agrobacterium tumefaciens' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          511693 
_em_entity_assembly_recombinant.organism             'Escherichia coli BL21' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         60 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 BIOCONTINUUM (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
_em_imaging_optics.chr_aberration_corrector   ? 
_em_imaging_optics.energyfilter_lower         ? 
_em_imaging_optics.energyfilter_slit_width    20 
_em_imaging_optics.energyfilter_name          ? 
_em_imaging_optics.energyfilter_upper         ? 
_em_imaging_optics.id                         1 
_em_imaging_optics.imaging_id                 1 
_em_imaging_optics.phase_plate                ? 
_em_imaging_optics.sph_aberration_corrector   ? 
_em_imaging_optics.details                    ? 
# 
_em_particle_selection.details                  ? 
_em_particle_selection.id                       1 
_em_particle_selection.image_processing_id      1 
_em_particle_selection.method                   ? 
_em_particle_selection.num_particles_selected   8864865 
_em_particle_selection.reference_model          ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'            ? 1  1 ? ? cryoSPARC       4.5.3 
'IMAGE ACQUISITION'             ? 2  ? ? 1 ?               ?     
MASKING                         ? 3  ? ? ? ?               ?     
'CTF CORRECTION'                ? 4  1 ? ? ?               ?     
'LAYERLINE INDEXING'            ? 5  ? ? ? ?               ?     
'DIFFRACTION INDEXING'          ? 6  ? ? ? ?               ?     
'MODEL FITTING'                 ? 7  ? 1 ? 'UCSF ChimeraX' 1.8   
OTHER                           ? 8  ? ? ? ?               ?     
'INITIAL EULER ASSIGNMENT'      ? 9  1 ? ? cryoSPARC       4.5.3 
'FINAL EULER ASSIGNMENT'        ? 10 1 ? ? cryoSPARC       4.5.3 
CLASSIFICATION                  ? 11 1 ? ? cryoSPARC       4.5.3 
RECONSTRUCTION                  ? 12 1 ? ? cryoSPARC       4.5.3 
'MODEL REFINEMENT'              ? 13 ? 1 ? 'UCSF ChimeraX' 1.8   
'VOLUME SELECTION'              ? 14 1 1 1 ?               ?     
'SERIES ALIGNMENT'              ? 15 1 1 1 ?               ?     
'MOLECULAR REPLACEMENT'         ? 16 1 1 1 ?               ?     
'LATTICE DISTORTION CORRECTION' ? 17 1 1 1 ?               ?     
'SYMMETRY DETERMINATION'        ? 18 1 1 1 ?               ?     
'CRYSTALLOGRAPHY MERGING'       ? 19 1 1 1 ?               ?     
# 
_em_specimen.concentration           1.2 
_em_specimen.details                 'homogeneous dimeric sample' 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'German Research Foundation (DFG)' Germany 'NA 240/11-2'                  1 
'German Research Foundation (DFG)' Germany 'Research Training Group 2341' 2 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'in silico model' 
_pdbx_initial_refinement_model.source_name      AlphaFold 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9HH1 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM 1    N N   . GLY A 1 95  ? 82.977  55.377  85.379  1.00 89.80 ? 95  GLY A N   1 
ATOM 2    C CA  . GLY A 1 95  ? 82.481  56.158  86.496  1.00 90.34 ? 95  GLY A CA  1 
ATOM 3    C C   . GLY A 1 95  ? 82.855  57.640  86.433  1.00 92.31 ? 95  GLY A C   1 
ATOM 4    O O   . GLY A 1 95  ? 83.460  58.130  85.480  1.00 90.71 ? 95  GLY A O   1 
ATOM 5    N N   . LYS A 1 96  ? 82.469  58.365  87.486  1.00 92.67 ? 96  LYS A N   1 
ATOM 6    C CA  . LYS A 1 96  ? 82.602  59.826  87.572  1.00 93.65 ? 96  LYS A CA  1 
ATOM 7    C C   . LYS A 1 96  ? 83.973  60.233  88.116  1.00 93.85 ? 96  LYS A C   1 
ATOM 8    O O   . LYS A 1 96  ? 84.389  59.748  89.169  1.00 92.12 ? 96  LYS A O   1 
ATOM 9    C CB  . LYS A 1 96  ? 81.437  60.372  88.416  1.00 91.93 ? 96  LYS A CB  1 
ATOM 10   C CG  . LYS A 1 96  ? 81.383  61.902  88.507  1.00 89.14 ? 96  LYS A CG  1 
ATOM 11   C CD  . LYS A 1 96  ? 80.093  62.348  89.191  1.00 86.53 ? 96  LYS A CD  1 
ATOM 12   C CE  . LYS A 1 96  ? 79.977  63.882  89.216  1.00 79.32 ? 96  LYS A CE  1 
ATOM 13   N NZ  . LYS A 1 96  ? 78.641  64.349  89.668  1.00 74.12 ? 96  LYS A NZ  1 
ATOM 14   N N   . LEU A 1 97  ? 84.613  61.181  87.426  1.00 94.06 ? 97  LEU A N   1 
ATOM 15   C CA  . LEU A 1 97  ? 85.780  61.902  87.915  1.00 95.18 ? 97  LEU A CA  1 
ATOM 16   C C   . LEU A 1 97  ? 85.409  63.374  88.114  1.00 95.84 ? 97  LEU A C   1 
ATOM 17   O O   . LEU A 1 97  ? 84.903  64.017  87.195  1.00 95.33 ? 97  LEU A O   1 
ATOM 18   C CB  . LEU A 1 97  ? 86.935  61.733  86.914  1.00 95.03 ? 97  LEU A CB  1 
ATOM 19   C CG  . LEU A 1 97  ? 88.258  62.337  87.396  1.00 94.82 ? 97  LEU A CG  1 
ATOM 20   C CD1 . LEU A 1 97  ? 88.897  61.498  88.507  1.00 91.19 ? 97  LEU A CD1 1 
ATOM 21   C CD2 . LEU A 1 97  ? 89.259  62.404  86.243  1.00 90.67 ? 97  LEU A CD2 1 
ATOM 22   N N   . ARG A 1 98  ? 85.666  63.910  89.294  1.00 95.46 ? 98  ARG A N   1 
ATOM 23   C CA  . ARG A 1 98  ? 85.453  65.327  89.608  1.00 95.16 ? 98  ARG A CA  1 
ATOM 24   C C   . ARG A 1 98  ? 86.759  66.094  89.413  1.00 95.29 ? 98  ARG A C   1 
ATOM 25   O O   . ARG A 1 98  ? 87.777  65.744  90.011  1.00 94.36 ? 98  ARG A O   1 
ATOM 26   C CB  . ARG A 1 98  ? 84.937  65.482  91.044  1.00 93.61 ? 98  ARG A CB  1 
ATOM 27   C CG  . ARG A 1 98  ? 83.583  64.789  91.281  1.00 89.54 ? 98  ARG A CG  1 
ATOM 28   C CD  . ARG A 1 98  ? 83.221  64.782  92.764  1.00 86.94 ? 98  ARG A CD  1 
ATOM 29   N NE  . ARG A 1 98  ? 84.182  63.973  93.521  1.00 79.89 ? 98  ARG A NE  1 
ATOM 30   C CZ  . ARG A 1 98  ? 84.420  64.018  94.828  1.00 76.23 ? 98  ARG A CZ  1 
ATOM 31   N NH1 . ARG A 1 98  ? 83.714  64.756  95.640  1.00 68.49 ? 98  ARG A NH1 1 
ATOM 32   N NH2 . ARG A 1 98  ? 85.388  63.311  95.313  1.00 68.44 ? 98  ARG A NH2 1 
ATOM 33   N N   . VAL A 1 99  ? 86.727  67.129  88.603  1.00 95.83 ? 99  VAL A N   1 
ATOM 34   C CA  . VAL A 1 99  ? 87.885  67.966  88.285  1.00 96.36 ? 99  VAL A CA  1 
ATOM 35   C C   . VAL A 1 99  ? 87.556  69.407  88.642  1.00 96.34 ? 99  VAL A C   1 
ATOM 36   O O   . VAL A 1 99  ? 86.569  69.947  88.150  1.00 95.66 ? 99  VAL A O   1 
ATOM 37   C CB  . VAL A 1 99  ? 88.257  67.865  86.791  1.00 96.13 ? 99  VAL A CB  1 
ATOM 38   C CG1 . VAL A 1 99  ? 89.563  68.614  86.501  1.00 93.26 ? 99  VAL A CG1 1 
ATOM 39   C CG2 . VAL A 1 99  ? 88.419  66.412  86.318  1.00 92.31 ? 99  VAL A CG2 1 
ATOM 40   N N   . THR A 1 100 ? 88.373  70.049  89.466  1.00 95.65 ? 100 THR A N   1 
ATOM 41   C CA  . THR A 1 100 ? 88.203  71.468  89.788  1.00 95.41 ? 100 THR A CA  1 
ATOM 42   C C   . THR A 1 100 ? 89.289  72.321  89.137  1.00 95.56 ? 100 THR A C   1 
ATOM 43   O O   . THR A 1 100 ? 90.433  71.891  88.978  1.00 95.08 ? 100 THR A O   1 
ATOM 44   C CB  . THR A 1 100 ? 88.088  71.703  91.307  1.00 94.35 ? 100 THR A CB  1 
ATOM 45   O OG1 . THR A 1 100 ? 87.735  73.056  91.544  1.00 89.06 ? 100 THR A OG1 1 
ATOM 46   C CG2 . THR A 1 100 ? 89.369  71.426  92.086  1.00 88.72 ? 100 THR A CG2 1 
ATOM 47   N N   . THR A 1 101 ? 88.933  73.535  88.731  1.00 95.55 ? 101 THR A N   1 
ATOM 48   C CA  . THR A 1 101 ? 89.879  74.554  88.263  1.00 95.79 ? 101 THR A CA  1 
ATOM 49   C C   . THR A 1 101 ? 89.229  75.937  88.358  1.00 95.33 ? 101 THR A C   1 
ATOM 50   O O   . THR A 1 101 ? 88.061  76.054  88.731  1.00 94.08 ? 101 THR A O   1 
ATOM 51   C CB  . THR A 1 101 ? 90.371  74.241  86.838  1.00 95.46 ? 101 THR A CB  1 
ATOM 52   O OG1 . THR A 1 101 ? 91.478  75.064  86.517  1.00 89.95 ? 101 THR A OG1 1 
ATOM 53   C CG2 . THR A 1 101 ? 89.313  74.446  85.751  1.00 89.20 ? 101 THR A CG2 1 
ATOM 54   N N   . THR A 1 102 ? 89.969  76.975  88.000  1.00 94.83 ? 102 THR A N   1 
ATOM 55   C CA  . THR A 1 102 ? 89.417  78.328  87.905  1.00 94.68 ? 102 THR A CA  1 
ATOM 56   C C   . THR A 1 102 ? 88.351  78.423  86.814  1.00 94.94 ? 102 THR A C   1 
ATOM 57   O O   . THR A 1 102 ? 88.373  77.682  85.829  1.00 94.22 ? 102 THR A O   1 
ATOM 58   C CB  . THR A 1 102 ? 90.513  79.365  87.635  1.00 93.56 ? 102 THR A CB  1 
ATOM 59   O OG1 . THR A 1 102 ? 91.072  79.173  86.352  1.00 86.94 ? 102 THR A OG1 1 
ATOM 60   C CG2 . THR A 1 102 ? 91.636  79.282  88.660  1.00 86.63 ? 102 THR A CG2 1 
ATOM 61   N N   . VAL A 1 103 ? 87.446  79.387  86.945  1.00 94.51 ? 103 VAL A N   1 
ATOM 62   C CA  . VAL A 1 103 ? 86.387  79.645  85.954  1.00 94.79 ? 103 VAL A CA  1 
ATOM 63   C C   . VAL A 1 103 ? 86.981  79.948  84.570  1.00 94.99 ? 103 VAL A C   1 
ATOM 64   O O   . VAL A 1 103 ? 86.554  79.368  83.582  1.00 93.81 ? 103 VAL A O   1 
ATOM 65   C CB  . VAL A 1 103 ? 85.472  80.795  86.420  1.00 94.09 ? 103 VAL A CB  1 
ATOM 66   C CG1 . VAL A 1 103 ? 84.369  81.084  85.400  1.00 91.32 ? 103 VAL A CG1 1 
ATOM 67   C CG2 . VAL A 1 103 ? 84.799  80.461  87.756  1.00 91.43 ? 103 VAL A CG2 1 
ATOM 68   N N   . GLY A 1 104 ? 88.012  80.783  84.500  1.00 93.94 ? 104 GLY A N   1 
ATOM 69   C CA  . GLY A 1 104 ? 88.656  81.160  83.243  1.00 93.77 ? 104 GLY A CA  1 
ATOM 70   C C   . GLY A 1 104 ? 89.276  79.981  82.499  1.00 94.49 ? 104 GLY A C   1 
ATOM 71   O O   . GLY A 1 104 ? 88.988  79.764  81.319  1.00 93.57 ? 104 GLY A O   1 
ATOM 72   N N   . LEU A 1 105 ? 90.086  79.167  83.190  1.00 94.76 ? 105 LEU A N   1 
ATOM 73   C CA  . LEU A 1 105 ? 90.717  77.992  82.580  1.00 94.97 ? 105 LEU A CA  1 
ATOM 74   C C   . LEU A 1 105 ? 89.676  76.930  82.200  1.00 94.97 ? 105 LEU A C   1 
ATOM 75   O O   . LEU A 1 105 ? 89.787  76.302  81.146  1.00 93.78 ? 105 LEU A O   1 
ATOM 76   C CB  . LEU A 1 105 ? 91.783  77.430  83.535  1.00 94.60 ? 105 LEU A CB  1 
ATOM 77   C CG  . LEU A 1 105 ? 92.642  76.319  82.887  1.00 93.11 ? 105 LEU A CG  1 
ATOM 78   C CD1 . LEU A 1 105 ? 93.600  76.891  81.836  1.00 86.03 ? 105 LEU A CD1 1 
ATOM 79   C CD2 . LEU A 1 105 ? 93.483  75.618  83.936  1.00 85.37 ? 105 LEU A CD2 1 
ATOM 80   N N   . GLY A 1 106 ? 88.655  76.751  83.030  1.00 95.61 ? 106 GLY A N   1 
ATOM 81   C CA  . GLY A 1 106 ? 87.578  75.816  82.769  1.00 95.82 ? 106 GLY A CA  1 
ATOM 82   C C   . GLY A 1 106 ? 86.775  76.167  81.520  1.00 96.29 ? 106 GLY A C   1 
ATOM 83   O O   . GLY A 1 106 ? 86.557  75.316  80.656  1.00 95.43 ? 106 GLY A O   1 
ATOM 84   N N   . GLN A 1 107 ? 86.391  77.424  81.395  1.00 95.20 ? 107 GLN A N   1 
ATOM 85   C CA  . GLN A 1 107 ? 85.622  77.923  80.255  1.00 94.82 ? 107 GLN A CA  1 
ATOM 86   C C   . GLN A 1 107 ? 86.468  78.074  78.980  1.00 94.35 ? 107 GLN A C   1 
ATOM 87   O O   . GLN A 1 107 ? 85.990  77.752  77.894  1.00 92.77 ? 107 GLN A O   1 
ATOM 88   C CB  . GLN A 1 107 ? 84.981  79.265  80.631  1.00 94.60 ? 107 GLN A CB  1 
ATOM 89   C CG  . GLN A 1 107 ? 83.876  79.101  81.689  1.00 93.69 ? 107 GLN A CG  1 
ATOM 90   C CD  . GLN A 1 107 ? 83.188  80.421  82.041  1.00 93.63 ? 107 GLN A CD  1 
ATOM 91   O OE1 . GLN A 1 107 ? 83.654  81.509  81.765  1.00 86.64 ? 107 GLN A OE1 1 
ATOM 92   N NE2 . GLN A 1 107 ? 82.026  80.352  82.652  1.00 85.94 ? 107 GLN A NE2 1 
ATOM 93   N N   . GLY A 1 108 ? 87.699  78.553  79.108  1.00 93.76 ? 108 GLY A N   1 
ATOM 94   C CA  . GLY A 1 108 ? 88.551  78.890  77.967  1.00 92.83 ? 108 GLY A CA  1 
ATOM 95   C C   . GLY A 1 108 ? 89.284  77.712  77.332  1.00 93.07 ? 108 GLY A C   1 
ATOM 96   O O   . GLY A 1 108 ? 89.532  77.728  76.126  1.00 90.42 ? 108 GLY A O   1 
ATOM 97   N N   . TRP A 1 109 ? 89.630  76.702  78.119  1.00 94.73 ? 109 TRP A N   1 
ATOM 98   C CA  . TRP A 1 109 ? 90.477  75.595  77.661  1.00 94.58 ? 109 TRP A CA  1 
ATOM 99   C C   . TRP A 1 109 ? 89.948  74.205  78.013  1.00 94.70 ? 109 TRP A C   1 
ATOM 100  O O   . TRP A 1 109 ? 89.866  73.333  77.143  1.00 93.47 ? 109 TRP A O   1 
ATOM 101  C CB  . TRP A 1 109 ? 91.889  75.803  78.221  1.00 93.77 ? 109 TRP A CB  1 
ATOM 102  C CG  . TRP A 1 109 ? 92.922  74.836  77.734  1.00 93.17 ? 109 TRP A CG  1 
ATOM 103  C CD1 . TRP A 1 109 ? 93.565  74.916  76.557  1.00 90.28 ? 109 TRP A CD1 1 
ATOM 104  C CD2 . TRP A 1 109 ? 93.446  73.652  78.417  1.00 92.10 ? 109 TRP A CD2 1 
ATOM 105  N NE1 . TRP A 1 109 ? 94.470  73.864  76.453  1.00 89.47 ? 109 TRP A NE1 1 
ATOM 106  C CE2 . TRP A 1 109 ? 94.430  73.069  77.577  1.00 90.89 ? 109 TRP A CE2 1 
ATOM 107  C CE3 . TRP A 1 109 ? 93.187  73.027  79.655  1.00 90.01 ? 109 TRP A CE3 1 
ATOM 108  C CZ2 . TRP A 1 109 ? 95.155  71.903  77.956  1.00 89.38 ? 109 TRP A CZ2 1 
ATOM 109  C CZ3 . TRP A 1 109 ? 93.904  71.859  80.033  1.00 88.32 ? 109 TRP A CZ3 1 
ATOM 110  C CH2 . TRP A 1 109 ? 94.876  71.313  79.185  1.00 88.48 ? 109 TRP A CH2 1 
ATOM 111  N N   . LEU A 1 110 ? 89.587  73.972  79.273  1.00 95.56 ? 110 LEU A N   1 
ATOM 112  C CA  . LEU A 1 110 ? 89.331  72.634  79.781  1.00 96.23 ? 110 LEU A CA  1 
ATOM 113  C C   . LEU A 1 110 ? 88.062  71.999  79.208  1.00 96.46 ? 110 LEU A C   1 
ATOM 114  O O   . LEU A 1 110 ? 88.066  70.798  78.956  1.00 95.79 ? 110 LEU A O   1 
ATOM 115  C CB  . LEU A 1 110 ? 89.324  72.673  81.320  1.00 96.14 ? 110 LEU A CB  1 
ATOM 116  C CG  . LEU A 1 110 ? 89.210  71.297  81.994  1.00 95.64 ? 110 LEU A CG  1 
ATOM 117  C CD1 . LEU A 1 110 ? 90.352  70.346  81.612  1.00 91.98 ? 110 LEU A CD1 1 
ATOM 118  C CD2 . LEU A 1 110 ? 89.244  71.471  83.517  1.00 91.54 ? 110 LEU A CD2 1 
ATOM 119  N N   . THR A 1 111 ? 87.008  72.763  78.945  1.00 95.61 ? 111 THR A N   1 
ATOM 120  C CA  . THR A 1 111 ? 85.761  72.247  78.358  1.00 95.52 ? 111 THR A CA  1 
ATOM 121  C C   . THR A 1 111 ? 86.022  71.551  77.019  1.00 95.24 ? 111 THR A C   1 
ATOM 122  O O   . THR A 1 111 ? 85.612  70.406  76.835  1.00 94.44 ? 111 THR A O   1 
ATOM 123  C CB  . THR A 1 111 ? 84.721  73.365  78.185  1.00 95.05 ? 111 THR A CB  1 
ATOM 124  O OG1 . THR A 1 111 ? 84.427  73.931  79.440  1.00 87.85 ? 111 THR A OG1 1 
ATOM 125  C CG2 . THR A 1 111 ? 83.400  72.853  77.611  1.00 87.39 ? 111 THR A CG2 1 
ATOM 126  N N   . ASP A 1 112 ? 86.781  72.178  76.127  1.00 94.44 ? 112 ASP A N   1 
ATOM 127  C CA  . ASP A 1 112 ? 87.148  71.602  74.829  1.00 93.03 ? 112 ASP A CA  1 
ATOM 128  C C   . ASP A 1 112 ? 88.040  70.359  74.995  1.00 92.92 ? 112 ASP A C   1 
ATOM 129  O O   . ASP A 1 112 ? 87.891  69.371  74.279  1.00 91.01 ? 112 ASP A O   1 
ATOM 130  C CB  . ASP A 1 112 ? 87.841  72.676  73.972  1.00 91.22 ? 112 ASP A CB  1 
ATOM 131  C CG  . ASP A 1 112 ? 86.888  73.733  73.402  1.00 88.14 ? 112 ASP A CG  1 
ATOM 132  O OD1 . ASP A 1 112 ? 85.933  74.163  74.085  1.00 81.41 ? 112 ASP A OD1 1 
ATOM 133  O OD2 . ASP A 1 112 ? 87.088  74.150  72.233  1.00 80.93 ? 112 ASP A OD2 1 
ATOM 134  N N   . LYS A 1 113 ? 88.939  70.352  75.982  1.00 93.76 ? 113 LYS A N   1 
ATOM 135  C CA  . LYS A 1 113 ? 89.758  69.173  76.282  1.00 92.98 ? 113 LYS A CA  1 
ATOM 136  C C   . LYS A 1 113 ? 88.944  68.017  76.842  1.00 93.38 ? 113 LYS A C   1 
ATOM 137  O O   . LYS A 1 113 ? 89.229  66.865  76.522  1.00 92.35 ? 113 LYS A O   1 
ATOM 138  C CB  . LYS A 1 113 ? 90.913  69.542  77.224  1.00 91.89 ? 113 LYS A CB  1 
ATOM 139  C CG  . LYS A 1 113 ? 91.888  70.577  76.636  1.00 89.63 ? 113 LYS A CG  1 
ATOM 140  C CD  . LYS A 1 113 ? 92.677  70.049  75.442  1.00 86.28 ? 113 LYS A CD  1 
ATOM 141  C CE  . LYS A 1 113 ? 93.012  71.172  74.444  1.00 83.83 ? 113 LYS A CE  1 
ATOM 142  N NZ  . LYS A 1 113 ? 92.079  71.158  73.298  1.00 77.24 ? 113 LYS A NZ  1 
ATOM 143  N N   . VAL A 1 114 ? 87.920  68.303  77.639  1.00 95.01 ? 114 VAL A N   1 
ATOM 144  C CA  . VAL A 1 114 ? 87.012  67.283  78.173  1.00 95.73 ? 114 VAL A CA  1 
ATOM 145  C C   . VAL A 1 114 ? 86.184  66.638  77.062  1.00 95.31 ? 114 VAL A C   1 
ATOM 146  O O   . VAL A 1 114 ? 85.947  65.439  77.121  1.00 94.41 ? 114 VAL A O   1 
ATOM 147  C CB  . VAL A 1 114 ? 86.118  67.875  79.282  1.00 95.51 ? 114 VAL A CB  1 
ATOM 148  C CG1 . VAL A 1 114 ? 84.958  66.956  79.682  1.00 89.96 ? 114 VAL A CG1 1 
ATOM 149  C CG2 . VAL A 1 114 ? 86.959  68.119  80.534  1.00 89.59 ? 114 VAL A CG2 1 
ATOM 150  N N   . GLN A 1 115 ? 85.797  67.377  76.014  1.00 94.36 ? 115 GLN A N   1 
ATOM 151  C CA  . GLN A 1 115 ? 85.166  66.789  74.829  1.00 92.70 ? 115 GLN A CA  1 
ATOM 152  C C   . GLN A 1 115 ? 86.072  65.736  74.192  1.00 91.87 ? 115 GLN A C   1 
ATOM 153  O O   . GLN A 1 115 ? 85.648  64.600  73.978  1.00 90.59 ? 115 GLN A O   1 
ATOM 154  C CB  . GLN A 1 115 ? 84.832  67.882  73.814  1.00 91.66 ? 115 GLN A CB  1 
ATOM 155  C CG  . GLN A 1 115 ? 84.101  67.329  72.577  1.00 85.25 ? 115 GLN A CG  1 
ATOM 156  C CD  . GLN A 1 115 ? 84.687  67.800  71.246  1.00 79.10 ? 115 GLN A CD  1 
ATOM 157  O OE1 . GLN A 1 115 ? 85.733  68.410  71.153  1.00 70.94 ? 115 GLN A OE1 1 
ATOM 158  N NE2 . GLN A 1 115 ? 84.014  67.505  70.146  1.00 67.98 ? 115 GLN A NE2 1 
ATOM 159  N N   . GLU A 1 116 ? 87.328  66.086  73.926  1.00 89.69 ? 116 GLU A N   1 
ATOM 160  C CA  . GLU A 1 116 ? 88.313  65.154  73.387  1.00 86.55 ? 116 GLU A CA  1 
ATOM 161  C C   . GLU A 1 116 ? 88.506  63.939  74.310  1.00 86.07 ? 116 GLU A C   1 
ATOM 162  O O   . GLU A 1 116 ? 88.557  62.810  73.835  1.00 84.36 ? 116 GLU A O   1 
ATOM 163  C CB  . GLU A 1 116 ? 89.659  65.877  73.173  1.00 84.31 ? 116 GLU A CB  1 
ATOM 164  C CG  . GLU A 1 116 ? 89.654  66.987  72.106  1.00 79.30 ? 116 GLU A CG  1 
ATOM 165  C CD  . GLU A 1 116 ? 90.996  67.762  72.082  1.00 77.29 ? 116 GLU A CD  1 
ATOM 166  O OE1 . GLU A 1 116 ? 91.008  69.006  72.021  1.00 70.29 ? 116 GLU A OE1 1 
ATOM 167  O OE2 . GLU A 1 116 ? 92.070  67.122  72.164  1.00 70.88 ? 116 GLU A OE2 1 
ATOM 168  N N   . PHE A 1 117 ? 88.551  64.153  75.632  1.00 89.58 ? 117 PHE A N   1 
ATOM 169  C CA  . PHE A 1 117 ? 88.705  63.084  76.613  1.00 89.98 ? 117 PHE A CA  1 
ATOM 170  C C   . PHE A 1 117 ? 87.524  62.105  76.621  1.00 88.93 ? 117 PHE A C   1 
ATOM 171  O O   . PHE A 1 117 ? 87.724  60.893  76.567  1.00 88.12 ? 117 PHE A O   1 
ATOM 172  C CB  . PHE A 1 117 ? 88.921  63.698  78.002  1.00 90.84 ? 117 PHE A CB  1 
ATOM 173  C CG  . PHE A 1 117 ? 89.089  62.659  79.089  1.00 91.59 ? 117 PHE A CG  1 
ATOM 174  C CD1 . PHE A 1 117 ? 88.015  62.335  79.934  1.00 88.87 ? 117 PHE A CD1 1 
ATOM 175  C CD2 . PHE A 1 117 ? 90.310  61.981  79.231  1.00 88.86 ? 117 PHE A CD2 1 
ATOM 176  C CE1 . PHE A 1 117 ? 88.161  61.339  80.914  1.00 89.17 ? 117 PHE A CE1 1 
ATOM 177  C CE2 . PHE A 1 117 ? 90.463  60.987  80.210  1.00 89.04 ? 117 PHE A CE2 1 
ATOM 178  C CZ  . PHE A 1 117 ? 89.386  60.660  81.053  1.00 91.84 ? 117 PHE A CZ  1 
ATOM 179  N N   . LEU A 1 118 ? 86.292  62.614  76.659  1.00 90.99 ? 118 LEU A N   1 
ATOM 180  C CA  . LEU A 1 118 ? 85.081  61.798  76.705  1.00 91.12 ? 118 LEU A CA  1 
ATOM 181  C C   . LEU A 1 118 ? 84.824  61.022  75.402  1.00 89.82 ? 118 LEU A C   1 
ATOM 182  O O   . LEU A 1 118 ? 84.143  60.000  75.427  1.00 88.30 ? 118 LEU A O   1 
ATOM 183  C CB  . LEU A 1 118 ? 83.880  62.681  77.046  1.00 92.17 ? 118 LEU A CB  1 
ATOM 184  C CG  . LEU A 1 118 ? 83.842  63.184  78.505  1.00 92.81 ? 118 LEU A CG  1 
ATOM 185  C CD1 . LEU A 1 118 ? 82.671  64.151  78.670  1.00 89.06 ? 118 LEU A CD1 1 
ATOM 186  C CD2 . LEU A 1 118 ? 83.670  62.042  79.513  1.00 89.19 ? 118 LEU A CD2 1 
ATOM 187  N N   . GLN A 1 119 ? 85.389  61.466  74.261  1.00 86.55 ? 119 GLN A N   1 
ATOM 188  C CA  . GLN A 1 119 ? 85.387  60.665  73.035  1.00 83.33 ? 119 GLN A CA  1 
ATOM 189  C C   . GLN A 1 119 ? 86.279  59.426  73.159  1.00 82.26 ? 119 GLN A C   1 
ATOM 190  O O   . GLN A 1 119 ? 85.984  58.402  72.555  1.00 79.52 ? 119 GLN A O   1 
ATOM 191  C CB  . GLN A 1 119 ? 85.837  61.514  71.838  1.00 80.93 ? 119 GLN A CB  1 
ATOM 192  C CG  . GLN A 1 119 ? 84.749  62.496  71.373  1.00 73.90 ? 119 GLN A CG  1 
ATOM 193  C CD  . GLN A 1 119 ? 85.148  63.277  70.109  1.00 69.60 ? 119 GLN A CD  1 
ATOM 194  O OE1 . GLN A 1 119 ? 86.269  63.227  69.629  1.00 62.17 ? 119 GLN A OE1 1 
ATOM 195  N NE2 . GLN A 1 119 ? 84.234  63.997  69.513  1.00 59.82 ? 119 GLN A NE2 1 
ATOM 196  N N   . LEU A 1 120 ? 87.355  59.513  73.954  1.00 83.18 ? 120 LEU A N   1 
ATOM 197  C CA  . LEU A 1 120 ? 88.302  58.418  74.163  1.00 80.75 ? 120 LEU A CA  1 
ATOM 198  C C   . LEU A 1 120 ? 87.841  57.449  75.254  1.00 80.54 ? 120 LEU A C   1 
ATOM 199  O O   . LEU A 1 120 ? 88.050  56.244  75.125  1.00 78.94 ? 120 LEU A O   1 
ATOM 200  C CB  . LEU A 1 120 ? 89.670  59.020  74.510  1.00 78.69 ? 120 LEU A CB  1 
ATOM 201  C CG  . LEU A 1 120 ? 90.221  59.978  73.448  1.00 74.84 ? 120 LEU A CG  1 
ATOM 202  C CD1 . LEU A 1 120 ? 91.468  60.686  73.970  1.00 71.37 ? 120 LEU A CD1 1 
ATOM 203  C CD2 . LEU A 1 120 ? 90.488  59.270  72.123  1.00 70.24 ? 120 LEU A CD2 1 
ATOM 204  N N   . TYR A 1 121 ? 87.183  57.971  76.286  1.00 84.78 ? 121 TYR A N   1 
ATOM 205  C CA  . TYR A 1 121 ? 86.719  57.217  77.448  1.00 86.10 ? 121 TYR A CA  1 
ATOM 206  C C   . TYR A 1 121 ? 85.201  57.384  77.641  1.00 87.63 ? 121 TYR A C   1 
ATOM 207  O O   . TYR A 1 121 ? 84.754  57.998  78.607  1.00 87.13 ? 121 TYR A O   1 
ATOM 208  C CB  . TYR A 1 121 ? 87.514  57.643  78.684  1.00 85.33 ? 121 TYR A CB  1 
ATOM 209  C CG  . TYR A 1 121 ? 89.011  57.521  78.509  1.00 84.34 ? 121 TYR A CG  1 
ATOM 210  C CD1 . TYR A 1 121 ? 89.651  56.276  78.595  1.00 81.43 ? 121 TYR A CD1 1 
ATOM 211  C CD2 . TYR A 1 121 ? 89.768  58.672  78.215  1.00 81.45 ? 121 TYR A CD2 1 
ATOM 212  C CE1 . TYR A 1 121 ? 91.036  56.176  78.400  1.00 80.11 ? 121 TYR A CE1 1 
ATOM 213  C CE2 . TYR A 1 121 ? 91.147  58.582  78.012  1.00 79.66 ? 121 TYR A CE2 1 
ATOM 214  C CZ  . TYR A 1 121 ? 91.783  57.332  78.100  1.00 81.51 ? 121 TYR A CZ  1 
ATOM 215  O OH  . TYR A 1 121 ? 93.132  57.263  77.900  1.00 79.64 ? 121 TYR A OH  1 
ATOM 216  N N   . PRO A 1 122 ? 84.380  56.842  76.723  1.00 86.79 ? 122 PRO A N   1 
ATOM 217  C CA  . PRO A 1 122 ? 82.936  57.079  76.722  1.00 86.69 ? 122 PRO A CA  1 
ATOM 218  C C   . PRO A 1 122 ? 82.195  56.475  77.919  1.00 88.44 ? 122 PRO A C   1 
ATOM 219  O O   . PRO A 1 122 ? 81.083  56.887  78.207  1.00 86.97 ? 122 PRO A O   1 
ATOM 220  C CB  . PRO A 1 122 ? 82.446  56.488  75.395  1.00 83.81 ? 122 PRO A CB  1 
ATOM 221  C CG  . PRO A 1 122 ? 83.465  55.399  75.082  1.00 81.63 ? 122 PRO A CG  1 
ATOM 222  C CD  . PRO A 1 122 ? 84.767  56.015  75.590  1.00 84.06 ? 122 PRO A CD  1 
ATOM 223  N N   . GLU A 1 123 ? 82.804  55.520  78.631  1.00 88.57 ? 123 GLU A N   1 
ATOM 224  C CA  . GLU A 1 123 ? 82.233  54.931  79.851  1.00 88.90 ? 123 GLU A CA  1 
ATOM 225  C C   . GLU A 1 123 ? 82.562  55.749  81.113  1.00 90.56 ? 123 GLU A C   1 
ATOM 226  O O   . GLU A 1 123 ? 82.074  55.436  82.210  1.00 88.66 ? 123 GLU A O   1 
ATOM 227  C CB  . GLU A 1 123 ? 82.655  53.460  79.998  1.00 86.46 ? 123 GLU A CB  1 
ATOM 228  C CG  . GLU A 1 123 ? 82.201  52.590  78.809  1.00 81.26 ? 123 GLU A CG  1 
ATOM 229  C CD  . GLU A 1 123 ? 82.094  51.089  79.135  1.00 73.03 ? 123 GLU A CD  1 
ATOM 230  O OE1 . GLU A 1 123 ? 82.433  50.246  78.256  1.00 64.09 ? 123 GLU A OE1 1 
ATOM 231  O OE2 . GLU A 1 123 ? 81.636  50.754  80.241  1.00 63.66 ? 123 GLU A OE2 1 
ATOM 232  N N   . MET A 1 124 ? 83.353  56.800  80.985  1.00 91.60 ? 124 MET A N   1 
ATOM 233  C CA  . MET A 1 124 ? 83.557  57.782  82.052  1.00 93.38 ? 124 MET A CA  1 
ATOM 234  C C   . MET A 1 124 ? 82.533  58.908  81.960  1.00 94.24 ? 124 MET A C   1 
ATOM 235  O O   . MET A 1 124 ? 82.005  59.236  80.906  1.00 93.30 ? 124 MET A O   1 
ATOM 236  C CB  . MET A 1 124 ? 84.990  58.325  82.036  1.00 92.72 ? 124 MET A CB  1 
ATOM 237  C CG  . MET A 1 124 ? 86.005  57.274  82.488  1.00 89.05 ? 124 MET A CG  1 
ATOM 238  S SD  . MET A 1 124 ? 87.696  57.900  82.737  1.00 90.19 ? 124 MET A SD  1 
ATOM 239  C CE  . MET A 1 124 ? 87.435  59.069  84.092  1.00 84.18 ? 124 MET A CE  1 
ATOM 240  N N   . SER A 1 125 ? 82.312  59.545  83.102  1.00 94.47 ? 125 SER A N   1 
ATOM 241  C CA  . SER A 1 125 ? 81.683  60.850  83.182  1.00 95.23 ? 125 SER A CA  1 
ATOM 242  C C   . SER A 1 125 ? 82.592  61.826  83.927  1.00 96.05 ? 125 SER A C   1 
ATOM 243  O O   . SER A 1 125 ? 83.397  61.431  84.775  1.00 94.70 ? 125 SER A O   1 
ATOM 244  C CB  . SER A 1 125 ? 80.288  60.752  83.807  1.00 93.16 ? 125 SER A CB  1 
ATOM 245  O OG  . SER A 1 125 ? 80.350  60.376  85.166  1.00 82.07 ? 125 SER A OG  1 
ATOM 246  N N   . ILE A 1 126 ? 82.482  63.101  83.595  1.00 95.69 ? 126 ILE A N   1 
ATOM 247  C CA  . ILE A 1 126 ? 83.259  64.171  84.224  1.00 96.56 ? 126 ILE A CA  1 
ATOM 248  C C   . ILE A 1 126 ? 82.307  65.165  84.894  1.00 96.58 ? 126 ILE A C   1 
ATOM 249  O O   . ILE A 1 126 ? 81.302  65.560  84.323  1.00 96.03 ? 126 ILE A O   1 
ATOM 250  C CB  . ILE A 1 126 ? 84.190  64.852  83.194  1.00 96.21 ? 126 ILE A CB  1 
ATOM 251  C CG1 . ILE A 1 126 ? 85.274  63.895  82.648  1.00 92.74 ? 126 ILE A CG1 1 
ATOM 252  C CG2 . ILE A 1 126 ? 84.853  66.112  83.765  1.00 93.17 ? 126 ILE A CG2 1 
ATOM 253  C CD1 . ILE A 1 126 ? 86.357  63.461  83.643  1.00 88.32 ? 126 ILE A CD1 1 
ATOM 254  N N   . GLN A 1 127 ? 82.677  65.597  86.089  1.00 95.59 ? 127 GLN A N   1 
ATOM 255  C CA  . GLN A 1 127 ? 82.136  66.817  86.684  1.00 95.32 ? 127 GLN A CA  1 
ATOM 256  C C   . GLN A 1 127 ? 83.251  67.860  86.749  1.00 95.30 ? 127 GLN A C   1 
ATOM 257  O O   . GLN A 1 127 ? 84.211  67.679  87.494  1.00 94.35 ? 127 GLN A O   1 
ATOM 258  C CB  . GLN A 1 127 ? 81.535  66.525  88.060  1.00 94.33 ? 127 GLN A CB  1 
ATOM 259  C CG  . GLN A 1 127 ? 80.977  67.795  88.734  1.00 93.58 ? 127 GLN A CG  1 
ATOM 260  C CD  . GLN A 1 127 ? 80.281  67.511  90.063  1.00 93.29 ? 127 GLN A CD  1 
ATOM 261  O OE1 . GLN A 1 127 ? 80.446  66.471  90.688  1.00 88.07 ? 127 GLN A OE1 1 
ATOM 262  N NE2 . GLN A 1 127 ? 79.478  68.439  90.560  1.00 85.82 ? 127 GLN A NE2 1 
ATOM 263  N N   . LEU A 1 128 ? 83.099  68.940  85.995  1.00 96.04 ? 128 LEU A N   1 
ATOM 264  C CA  . LEU A 1 128 ? 83.917  70.133  86.161  1.00 96.22 ? 128 LEU A CA  1 
ATOM 265  C C   . LEU A 1 128 ? 83.285  71.026  87.223  1.00 95.91 ? 128 LEU A C   1 
ATOM 266  O O   . LEU A 1 128 ? 82.113  71.403  87.119  1.00 95.21 ? 128 LEU A O   1 
ATOM 267  C CB  . LEU A 1 128 ? 84.078  70.885  84.830  1.00 96.12 ? 128 LEU A CB  1 
ATOM 268  C CG  . LEU A 1 128 ? 84.755  70.086  83.701  1.00 94.61 ? 128 LEU A CG  1 
ATOM 269  C CD1 . LEU A 1 128 ? 84.972  70.999  82.493  1.00 90.30 ? 128 LEU A CD1 1 
ATOM 270  C CD2 . LEU A 1 128 ? 86.105  69.515  84.121  1.00 91.09 ? 128 LEU A CD2 1 
ATOM 271  N N   . ILE A 1 129 ? 84.069  71.360  88.240  1.00 95.79 ? 129 ILE A N   1 
ATOM 272  C CA  . ILE A 1 129 ? 83.700  72.284  89.309  1.00 94.88 ? 129 ILE A CA  1 
ATOM 273  C C   . ILE A 1 129 ? 84.577  73.515  89.140  1.00 94.48 ? 129 ILE A C   1 
ATOM 274  O O   . ILE A 1 129 ? 85.768  73.498  89.478  1.00 93.26 ? 129 ILE A O   1 
ATOM 275  C CB  . ILE A 1 129 ? 83.848  71.620  90.698  1.00 94.07 ? 129 ILE A CB  1 
ATOM 276  C CG1 . ILE A 1 129 ? 83.092  70.265  90.773  1.00 91.44 ? 129 ILE A CG1 1 
ATOM 277  C CG2 . ILE A 1 129 ? 83.330  72.589  91.774  1.00 90.34 ? 129 ILE A CG2 1 
ATOM 278  C CD1 . ILE A 1 129 ? 83.471  69.430  92.006  1.00 85.69 ? 129 ILE A CD1 1 
ATOM 279  N N   . LEU A 1 130 ? 84.006  74.558  88.527  1.00 95.02 ? 130 LEU A N   1 
ATOM 280  C CA  . LEU A 1 130 ? 84.715  75.795  88.234  1.00 94.83 ? 130 LEU A CA  1 
ATOM 281  C C   . LEU A 1 130 ? 84.507  76.768  89.389  1.00 93.73 ? 130 LEU A C   1 
ATOM 282  O O   . LEU A 1 130 ? 83.374  77.151  89.680  1.00 91.67 ? 130 LEU A O   1 
ATOM 283  C CB  . LEU A 1 130 ? 84.249  76.385  86.895  1.00 94.74 ? 130 LEU A CB  1 
ATOM 284  C CG  . LEU A 1 130 ? 84.269  75.409  85.702  1.00 94.73 ? 130 LEU A CG  1 
ATOM 285  C CD1 . LEU A 1 130 ? 83.947  76.169  84.413  1.00 91.71 ? 130 LEU A CD1 1 
ATOM 286  C CD2 . LEU A 1 130 ? 85.606  74.705  85.513  1.00 91.14 ? 130 LEU A CD2 1 
ATOM 287  N N   . ASP A 1 131 ? 85.605  77.151  90.020  1.00 92.85 ? 131 ASP A N   1 
ATOM 288  C CA  . ASP A 1 131 ? 85.591  78.093  91.136  1.00 91.78 ? 131 ASP A CA  1 
ATOM 289  C C   . ASP A 1 131 ? 86.884  78.910  91.134  1.00 91.78 ? 131 ASP A C   1 
ATOM 290  O O   . ASP A 1 131 ? 87.969  78.392  90.843  1.00 89.82 ? 131 ASP A O   1 
ATOM 291  C CB  . ASP A 1 131 ? 85.406  77.325  92.450  1.00 89.53 ? 131 ASP A CB  1 
ATOM 292  C CG  . ASP A 1 131 ? 84.857  78.218  93.564  1.00 86.73 ? 131 ASP A CG  1 
ATOM 293  O OD1 . ASP A 1 131 ? 85.141  79.432  93.521  1.00 80.72 ? 131 ASP A OD1 1 
ATOM 294  O OD2 . ASP A 1 131 ? 84.145  77.671  94.433  1.00 79.28 ? 131 ASP A OD2 1 
ATOM 295  N N   . ASN A 1 132 ? 86.768  80.208  91.402  1.00 89.83 ? 132 ASN A N   1 
ATOM 296  C CA  . ASN A 1 132 ? 87.933  81.062  91.569  1.00 88.91 ? 132 ASN A CA  1 
ATOM 297  C C   . ASN A 1 132 ? 88.483  80.997  92.993  1.00 87.77 ? 132 ASN A C   1 
ATOM 298  O O   . ASN A 1 132 ? 89.647  81.323  93.206  1.00 83.65 ? 132 ASN A O   1 
ATOM 299  C CB  . ASN A 1 132 ? 87.604  82.488  91.114  1.00 87.70 ? 132 ASN A CB  1 
ATOM 300  C CG  . ASN A 1 132 ? 87.494  82.627  89.603  1.00 88.29 ? 132 ASN A CG  1 
ATOM 301  O OD1 . ASN A 1 132 ? 88.034  81.856  88.826  1.00 82.84 ? 132 ASN A OD1 1 
ATOM 302  N ND2 . ASN A 1 132 ? 86.821  83.657  89.144  1.00 82.25 ? 132 ASN A ND2 1 
ATOM 303  N N   . GLU A 1 133 ? 87.690  80.523  93.960  1.00 86.31 ? 133 GLU A N   1 
ATOM 304  C CA  . GLU A 1 133 ? 88.239  80.072  95.227  1.00 84.35 ? 133 GLU A CA  1 
ATOM 305  C C   . GLU A 1 133 ? 88.858  78.677  95.042  1.00 84.05 ? 133 GLU A C   1 
ATOM 306  O O   . GLU A 1 133 ? 88.339  77.812  94.333  1.00 78.60 ? 133 GLU A O   1 
ATOM 307  C CB  . GLU A 1 133 ? 87.193  80.117  96.342  1.00 80.74 ? 133 GLU A CB  1 
ATOM 308  C CG  . GLU A 1 133 ? 86.684  81.550  96.580  1.00 72.20 ? 133 GLU A CG  1 
ATOM 309  C CD  . GLU A 1 133 ? 86.010  81.764  97.942  1.00 64.83 ? 133 GLU A CD  1 
ATOM 310  O OE1 . GLU A 1 133 ? 85.871  82.948  98.329  1.00 55.83 ? 133 GLU A OE1 1 
ATOM 311  O OE2 . GLU A 1 133 ? 85.719  80.769  98.648  1.00 56.03 ? 133 GLU A OE2 1 
ATOM 312  N N   . GLU A 1 134 ? 90.028  78.456  95.620  1.00 82.61 ? 134 GLU A N   1 
ATOM 313  C CA  . GLU A 1 134 ? 90.694  77.163  95.503  1.00 82.97 ? 134 GLU A CA  1 
ATOM 314  C C   . GLU A 1 134 ? 89.999  76.119  96.380  1.00 82.82 ? 134 GLU A C   1 
ATOM 315  O O   . GLU A 1 134 ? 90.332  75.954  97.548  1.00 77.92 ? 134 GLU A O   1 
ATOM 316  C CB  . GLU A 1 134 ? 92.195  77.274  95.829  1.00 79.14 ? 134 GLU A CB  1 
ATOM 317  C CG  . GLU A 1 134 ? 93.034  77.758  94.643  1.00 74.47 ? 134 GLU A CG  1 
ATOM 318  C CD  . GLU A 1 134 ? 94.552  77.724  94.946  1.00 73.20 ? 134 GLU A CD  1 
ATOM 319  O OE1 . GLU A 1 134 ? 95.358  77.892  94.005  1.00 67.16 ? 134 GLU A OE1 1 
ATOM 320  O OE2 . GLU A 1 134 ? 94.955  77.587  96.120  1.00 71.61 ? 134 GLU A OE2 1 
ATOM 321  N N   . LEU A 1 135 ? 89.065  75.367  95.784  1.00 78.92 ? 135 LEU A N   1 
ATOM 322  C CA  . LEU A 1 135 ? 88.415  74.244  96.450  1.00 78.04 ? 135 LEU A CA  1 
ATOM 323  C C   . LEU A 1 135 ? 89.445  73.235  96.962  1.00 79.33 ? 135 LEU A C   1 
ATOM 324  O O   . LEU A 1 135 ? 90.322  72.783  96.217  1.00 74.69 ? 135 LEU A O   1 
ATOM 325  C CB  . LEU A 1 135 ? 87.440  73.556  95.491  1.00 73.74 ? 135 LEU A CB  1 
ATOM 326  C CG  . LEU A 1 135 ? 86.202  74.391  95.127  1.00 69.20 ? 135 LEU A CG  1 
ATOM 327  C CD1 . LEU A 1 135 ? 85.408  73.652  94.048  1.00 64.06 ? 135 LEU A CD1 1 
ATOM 328  C CD2 . LEU A 1 135 ? 85.286  74.611  96.330  1.00 63.83 ? 135 LEU A CD2 1 
ATOM 329  N N   . ASP A 1 136 ? 89.310  72.835  98.221  1.00 78.67 ? 136 ASP A N   1 
ATOM 330  C CA  . ASP A 1 136 ? 90.213  71.876  98.840  1.00 77.03 ? 136 ASP A CA  1 
ATOM 331  C C   . ASP A 1 136 ? 89.977  70.459  98.279  1.00 78.16 ? 136 ASP A C   1 
ATOM 332  O O   . ASP A 1 136 ? 88.954  69.821  98.499  1.00 72.73 ? 136 ASP A O   1 
ATOM 333  C CB  . ASP A 1 136 ? 90.099  71.934  100.364 1.00 71.41 ? 136 ASP A CB  1 
ATOM 334  C CG  . ASP A 1 136 ? 91.255  71.206  101.057 1.00 65.19 ? 136 ASP A CG  1 
ATOM 335  O OD1 . ASP A 1 136 ? 91.848  70.279  100.447 1.00 58.47 ? 136 ASP A OD1 1 
ATOM 336  O OD2 . ASP A 1 136 ? 91.561  71.579  102.210 1.00 59.06 ? 136 ASP A OD2 1 
ATOM 337  N N   . VAL A 1 137 ? 90.965  69.977  97.530  1.00 76.72 ? 137 VAL A N   1 
ATOM 338  C CA  . VAL A 1 137 ? 90.922  68.642  96.915  1.00 75.14 ? 137 VAL A CA  1 
ATOM 339  C C   . VAL A 1 137 ? 91.030  67.545  97.971  1.00 75.43 ? 137 VAL A C   1 
ATOM 340  O O   . VAL A 1 137 ? 90.408  66.497  97.835  1.00 70.10 ? 137 VAL A O   1 
ATOM 341  C CB  . VAL A 1 137 ? 92.042  68.495  95.863  1.00 70.29 ? 137 VAL A CB  1 
ATOM 342  C CG1 . VAL A 1 137 ? 91.864  67.223  95.042  1.00 64.51 ? 137 VAL A CG1 1 
ATOM 343  C CG2 . VAL A 1 137 ? 92.083  69.669  94.883  1.00 64.90 ? 137 VAL A CG2 1 
ATOM 344  N N   . ASN A 1 138 ? 91.775  67.791  99.043  1.00 73.98 ? 138 ASN A N   1 
ATOM 345  C CA  . ASN A 1 138 ? 91.924  66.816  100.118 1.00 71.28 ? 138 ASN A CA  1 
ATOM 346  C C   . ASN A 1 138 ? 90.639  66.641  100.940 1.00 72.27 ? 138 ASN A C   1 
ATOM 347  O O   . ASN A 1 138 ? 90.363  65.542  101.411 1.00 65.65 ? 138 ASN A O   1 
ATOM 348  C CB  . ASN A 1 138 ? 93.110  67.216  101.004 1.00 64.45 ? 138 ASN A CB  1 
ATOM 349  C CG  . ASN A 1 138 ? 94.439  67.000  100.298 1.00 58.73 ? 138 ASN A CG  1 
ATOM 350  O OD1 . ASN A 1 138 ? 94.594  66.146  99.444  1.00 52.59 ? 138 ASN A OD1 1 
ATOM 351  N ND2 . ASN A 1 138 ? 95.443  67.760  100.673 1.00 51.82 ? 138 ASN A ND2 1 
ATOM 352  N N   . MET A 1 139 ? 89.809  67.671  101.020 1.00 69.23 ? 139 MET A N   1 
ATOM 353  C CA  . MET A 1 139 ? 88.464  67.564  101.606 1.00 66.51 ? 139 MET A CA  1 
ATOM 354  C C   . MET A 1 139 ? 87.456  66.847  100.685 1.00 70.03 ? 139 MET A C   1 
ATOM 355  O O   . MET A 1 139 ? 86.259  66.859  100.969 1.00 62.92 ? 139 MET A O   1 
ATOM 356  C CB  . MET A 1 139 ? 87.952  68.930  102.049 1.00 58.31 ? 139 MET A CB  1 
ATOM 357  C CG  . MET A 1 139 ? 88.735  69.483  103.238 1.00 51.29 ? 139 MET A CG  1 
ATOM 358  S SD  . MET A 1 139 ? 87.827  70.800  104.101 1.00 43.76 ? 139 MET A SD  1 
ATOM 359  C CE  . MET A 1 139 ? 89.127  71.393  105.202 1.00 37.89 ? 139 MET A CE  1 
ATOM 360  N N   . ARG A 1 140 ? 87.920  66.206  99.616  1.00 75.81 ? 140 ARG A N   1 
ATOM 361  C CA  . ARG A 1 140 ? 87.097  65.433  98.671  1.00 76.29 ? 140 ARG A CA  1 
ATOM 362  C C   . ARG A 1 140 ? 85.994  66.246  97.978  1.00 80.17 ? 140 ARG A C   1 
ATOM 363  O O   . ARG A 1 140 ? 84.998  65.664  97.535  1.00 74.78 ? 140 ARG A O   1 
ATOM 364  C CB  . ARG A 1 140 ? 86.552  64.157  99.331  1.00 69.19 ? 140 ARG A CB  1 
ATOM 365  C CG  . ARG A 1 140 ? 87.648  63.246  99.899  1.00 60.03 ? 140 ARG A CG  1 
ATOM 366  C CD  . ARG A 1 140 ? 87.004  61.985  100.473 1.00 54.58 ? 140 ARG A CD  1 
ATOM 367  N NE  . ARG A 1 140 ? 88.013  61.013  100.886 1.00 47.94 ? 140 ARG A NE  1 
ATOM 368  C CZ  . ARG A 1 140 ? 87.807  59.818  101.409 1.00 41.21 ? 140 ARG A CZ  1 
ATOM 369  N NH1 . ARG A 1 140 ? 86.604  59.375  101.638 1.00 37.47 ? 140 ARG A NH1 1 
ATOM 370  N NH2 . ARG A 1 140 ? 88.830  59.073  101.698 1.00 35.64 ? 140 ARG A NH2 1 
ATOM 371  N N   . HIS A 1 141 ? 86.166  67.554  97.857  1.00 82.99 ? 141 HIS A N   1 
ATOM 372  C CA  . HIS A 1 141 ? 85.305  68.385  97.011  1.00 82.98 ? 141 HIS A CA  1 
ATOM 373  C C   . HIS A 1 141 ? 85.500  68.055  95.527  1.00 85.61 ? 141 HIS A C   1 
ATOM 374  O O   . HIS A 1 141 ? 84.549  68.079  94.756  1.00 82.38 ? 141 HIS A O   1 
ATOM 375  C CB  . HIS A 1 141 ? 85.581  69.870  97.290  1.00 78.44 ? 141 HIS A CB  1 
ATOM 376  C CG  . HIS A 1 141 ? 85.210  70.334  98.678  1.00 73.23 ? 141 HIS A CG  1 
ATOM 377  N ND1 . HIS A 1 141 ? 85.387  71.613  99.168  1.00 63.76 ? 141 HIS A ND1 1 
ATOM 378  C CD2 . HIS A 1 141 ? 84.615  69.618  99.686  1.00 62.81 ? 141 HIS A CD2 1 
ATOM 379  C CE1 . HIS A 1 141 ? 84.928  71.662  100.421 1.00 59.44 ? 141 HIS A CE1 1 
ATOM 380  N NE2 . HIS A 1 141 ? 84.449  70.457  100.775 1.00 59.80 ? 141 HIS A NE2 1 
ATOM 381  N N   . ALA A 1 142 ? 86.723  67.669  95.138  1.00 89.21 ? 142 ALA A N   1 
ATOM 382  C CA  . ALA A 1 142 ? 87.071  67.138  93.827  1.00 90.78 ? 142 ALA A CA  1 
ATOM 383  C C   . ALA A 1 142 ? 88.065  65.967  93.954  1.00 91.44 ? 142 ALA A C   1 
ATOM 384  O O   . ALA A 1 142 ? 88.639  65.743  95.012  1.00 89.40 ? 142 ALA A O   1 
ATOM 385  C CB  . ALA A 1 142 ? 87.626  68.284  92.971  1.00 89.49 ? 142 ALA A CB  1 
ATOM 386  N N   . ASP A 1 143 ? 88.262  65.229  92.855  1.00 93.36 ? 143 ASP A N   1 
ATOM 387  C CA  . ASP A 1 143 ? 89.232  64.133  92.790  1.00 93.32 ? 143 ASP A CA  1 
ATOM 388  C C   . ASP A 1 143 ? 90.622  64.612  92.325  1.00 93.74 ? 143 ASP A C   1 
ATOM 389  O O   . ASP A 1 143 ? 91.637  63.976  92.613  1.00 92.58 ? 143 ASP A O   1 
ATOM 390  C CB  . ASP A 1 143 ? 88.708  63.049  91.833  1.00 92.60 ? 143 ASP A CB  1 
ATOM 391  C CG  . ASP A 1 143 ? 87.357  62.448  92.221  1.00 92.35 ? 143 ASP A CG  1 
ATOM 392  O OD1 . ASP A 1 143 ? 87.184  62.018  93.386  1.00 88.50 ? 143 ASP A OD1 1 
ATOM 393  O OD2 . ASP A 1 143 ? 86.480  62.343  91.336  1.00 88.23 ? 143 ASP A OD2 1 
ATOM 394  N N   . CYS A 1 144 ? 90.662  65.713  91.578  1.00 94.76 ? 144 CYS A N   1 
ATOM 395  C CA  . CYS A 1 144 ? 91.873  66.355  91.085  1.00 95.21 ? 144 CYS A CA  1 
ATOM 396  C C   . CYS A 1 144 ? 91.608  67.834  90.758  1.00 95.44 ? 144 CYS A C   1 
ATOM 397  O O   . CYS A 1 144 ? 90.460  68.268  90.673  1.00 94.94 ? 144 CYS A O   1 
ATOM 398  C CB  . CYS A 1 144 ? 92.410  65.590  89.867  1.00 95.11 ? 144 CYS A CB  1 
ATOM 399  S SG  . CYS A 1 144 ? 91.202  65.519  88.512  1.00 94.50 ? 144 CYS A SG  1 
ATOM 400  N N   . ALA A 1 145 ? 92.682  68.595  90.543  1.00 95.69 ? 145 ALA A N   1 
ATOM 401  C CA  . ALA A 1 145 ? 92.595  70.009  90.213  1.00 95.60 ? 145 ALA A CA  1 
ATOM 402  C C   . ALA A 1 145 ? 93.630  70.438  89.172  1.00 95.85 ? 145 ALA A C   1 
ATOM 403  O O   . ALA A 1 145 ? 94.729  69.881  89.109  1.00 95.40 ? 145 ALA A O   1 
ATOM 404  C CB  . ALA A 1 145 ? 92.741  70.833  91.495  1.00 94.71 ? 145 ALA A CB  1 
ATOM 405  N N   . ILE A 1 146 ? 93.312  71.474  88.413  1.00 96.07 ? 146 ILE A N   1 
ATOM 406  C CA  . ILE A 1 146 ? 94.290  72.282  87.684  1.00 96.18 ? 146 ILE A CA  1 
ATOM 407  C C   . ILE A 1 146 ? 94.383  73.638  88.392  1.00 95.56 ? 146 ILE A C   1 
ATOM 408  O O   . ILE A 1 146 ? 93.383  74.343  88.531  1.00 94.60 ? 146 ILE A O   1 
ATOM 409  C CB  . ILE A 1 146 ? 93.947  72.421  86.187  1.00 96.21 ? 146 ILE A CB  1 
ATOM 410  C CG1 . ILE A 1 146 ? 93.810  71.029  85.530  1.00 94.49 ? 146 ILE A CG1 1 
ATOM 411  C CG2 . ILE A 1 146 ? 95.043  73.244  85.486  1.00 94.20 ? 146 ILE A CG2 1 
ATOM 412  C CD1 . ILE A 1 146 ? 93.311  71.072  84.083  1.00 90.42 ? 146 ILE A CD1 1 
ATOM 413  N N   . ARG A 1 147 ? 95.587  73.990  88.848  1.00 95.22 ? 147 ARG A N   1 
ATOM 414  C CA  . ARG A 1 147 ? 95.872  75.227  89.589  1.00 94.80 ? 147 ARG A CA  1 
ATOM 415  C C   . ARG A 1 147 ? 96.714  76.181  88.740  1.00 94.72 ? 147 ARG A C   1 
ATOM 416  O O   . ARG A 1 147 ? 97.566  75.736  87.979  1.00 93.70 ? 147 ARG A O   1 
ATOM 417  C CB  . ARG A 1 147 ? 96.606  74.905  90.905  1.00 93.67 ? 147 ARG A CB  1 
ATOM 418  C CG  . ARG A 1 147 ? 95.835  73.997  91.874  1.00 90.64 ? 147 ARG A CG  1 
ATOM 419  C CD  . ARG A 1 147 ? 94.530  74.633  92.344  1.00 88.46 ? 147 ARG A CD  1 
ATOM 420  N NE  . ARG A 1 147 ? 93.929  73.865  93.440  1.00 86.98 ? 147 ARG A NE  1 
ATOM 421  C CZ  . ARG A 1 147 ? 92.661  73.875  93.807  1.00 84.68 ? 147 ARG A CZ  1 
ATOM 422  N NH1 . ARG A 1 147 ? 91.756  74.589  93.179  1.00 77.42 ? 147 ARG A NH1 1 
ATOM 423  N NH2 . ARG A 1 147 ? 92.266  73.158  94.798  1.00 80.95 ? 147 ARG A NH2 1 
ATOM 424  N N   . LEU A 1 148 ? 96.503  77.484  88.911  1.00 93.97 ? 148 LEU A N   1 
ATOM 425  C CA  . LEU A 1 148 ? 97.292  78.539  88.261  1.00 93.29 ? 148 LEU A CA  1 
ATOM 426  C C   . LEU A 1 148 ? 98.552  78.935  89.047  1.00 92.49 ? 148 LEU A C   1 
ATOM 427  O O   . LEU A 1 148 ? 99.277  79.847  88.653  1.00 88.87 ? 148 LEU A O   1 
ATOM 428  C CB  . LEU A 1 148 ? 96.404  79.767  87.994  1.00 92.14 ? 148 LEU A CB  1 
ATOM 429  C CG  . LEU A 1 148 ? 95.141  79.527  87.149  1.00 90.56 ? 148 LEU A CG  1 
ATOM 430  C CD1 . LEU A 1 148 ? 94.522  80.875  86.791  1.00 83.29 ? 148 LEU A CD1 1 
ATOM 431  C CD2 . LEU A 1 148 ? 95.407  78.772  85.859  1.00 82.82 ? 148 LEU A CD2 1 
ATOM 432  N N   . ARG A 1 149 ? 98.818  78.280  90.172  1.00 92.36 ? 149 ARG A N   1 
ATOM 433  C CA  . ARG A 1 149 ? 100.032 78.407  90.977  1.00 91.88 ? 149 ARG A CA  1 
ATOM 434  C C   . ARG A 1 149 ? 100.453 77.036  91.488  1.00 92.65 ? 149 ARG A C   1 
ATOM 435  O O   . ARG A 1 149 ? 99.645  76.107  91.524  1.00 91.17 ? 149 ARG A O   1 
ATOM 436  C CB  . ARG A 1 149 ? 99.826  79.422  92.116  1.00 88.79 ? 149 ARG A CB  1 
ATOM 437  C CG  . ARG A 1 149 ? 98.788  78.973  93.161  1.00 83.23 ? 149 ARG A CG  1 
ATOM 438  C CD  . ARG A 1 149 ? 98.634  80.039  94.247  1.00 81.49 ? 149 ARG A CD  1 
ATOM 439  N NE  . ARG A 1 149 ? 97.638  79.635  95.247  1.00 75.99 ? 149 ARG A NE  1 
ATOM 440  C CZ  . ARG A 1 149 ? 97.242  80.334  96.297  1.00 72.62 ? 149 ARG A CZ  1 
ATOM 441  N NH1 . ARG A 1 149 ? 97.749  81.502  96.581  1.00 67.53 ? 149 ARG A NH1 1 
ATOM 442  N NH2 . ARG A 1 149 ? 96.322  79.857  97.067  1.00 66.46 ? 149 ARG A NH2 1 
ATOM 443  N N   . GLN A 1 150 ? 101.704 76.917  91.910  1.00 91.33 ? 150 GLN A N   1 
ATOM 444  C CA  . GLN A 1 150 ? 102.193 75.661  92.466  1.00 91.68 ? 150 GLN A CA  1 
ATOM 445  C C   . GLN A 1 150 ? 101.460 75.341  93.780  1.00 91.19 ? 150 GLN A C   1 
ATOM 446  O O   . GLN A 1 150 ? 101.513 76.139  94.710  1.00 88.73 ? 150 GLN A O   1 
ATOM 447  C CB  . GLN A 1 150 ? 103.713 75.732  92.655  1.00 90.83 ? 150 GLN A CB  1 
ATOM 448  C CG  . GLN A 1 150 ? 104.273 74.357  93.032  1.00 87.78 ? 150 GLN A CG  1 
ATOM 449  C CD  . GLN A 1 150 ? 105.804 74.297  93.075  1.00 85.75 ? 150 GLN A CD  1 
ATOM 450  O OE1 . GLN A 1 150 ? 106.502 75.294  93.030  1.00 79.81 ? 150 GLN A OE1 1 
ATOM 451  N NE2 . GLN A 1 150 ? 106.359 73.117  93.182  1.00 77.54 ? 150 GLN A NE2 1 
ATOM 452  N N   . PRO A 1 151 ? 100.812 74.163  93.888  1.00 90.71 ? 151 PRO A N   1 
ATOM 453  C CA  . PRO A 1 151 ? 100.194 73.732  95.133  1.00 90.03 ? 151 PRO A CA  1 
ATOM 454  C C   . PRO A 1 151 ? 101.232 73.640  96.260  1.00 89.50 ? 151 PRO A C   1 
ATOM 455  O O   . PRO A 1 151 ? 102.312 73.083  96.072  1.00 86.89 ? 151 PRO A O   1 
ATOM 456  C CB  . PRO A 1 151 ? 99.553  72.373  94.831  1.00 88.26 ? 151 PRO A CB  1 
ATOM 457  C CG  . PRO A 1 151 ? 99.350  72.398  93.319  1.00 86.40 ? 151 PRO A CG  1 
ATOM 458  C CD  . PRO A 1 151 ? 100.549 73.202  92.826  1.00 89.53 ? 151 PRO A CD  1 
ATOM 459  N N   . GLN A 1 152 ? 100.881 74.175  97.416  1.00 88.07 ? 152 GLN A N   1 
ATOM 460  C CA  . GLN A 1 152 ? 101.755 74.196  98.595  1.00 86.25 ? 152 GLN A CA  1 
ATOM 461  C C   . GLN A 1 152 ? 101.494 73.032  99.559  1.00 85.45 ? 152 GLN A C   1 
ATOM 462  O O   . GLN A 1 152 ? 102.300 72.784  100.452 1.00 80.50 ? 152 GLN A O   1 
ATOM 463  C CB  . GLN A 1 152 ? 101.598 75.544  99.318  1.00 83.61 ? 152 GLN A CB  1 
ATOM 464  C CG  . GLN A 1 152 ? 102.014 76.754  98.462  1.00 76.42 ? 152 GLN A CG  1 
ATOM 465  C CD  . GLN A 1 152 ? 103.498 76.712  98.059  1.00 69.72 ? 152 GLN A CD  1 
ATOM 466  O OE1 . GLN A 1 152 ? 104.378 76.498  98.874  1.00 62.00 ? 152 GLN A OE1 1 
ATOM 467  N NE2 . GLN A 1 152 ? 103.801 76.911  96.796  1.00 59.62 ? 152 GLN A NE2 1 
ATOM 468  N N   . GLN A 1 153 ? 100.386 72.310  99.390  1.00 84.66 ? 153 GLN A N   1 
ATOM 469  C CA  . GLN A 1 153 ? 100.073 71.138  100.203 1.00 83.05 ? 153 GLN A CA  1 
ATOM 470  C C   . GLN A 1 153 ? 101.029 69.992  99.883  1.00 83.74 ? 153 GLN A C   1 
ATOM 471  O O   . GLN A 1 153 ? 101.159 69.560  98.732  1.00 80.06 ? 153 GLN A O   1 
ATOM 472  C CB  . GLN A 1 153 ? 98.609  70.731  100.018 1.00 78.90 ? 153 GLN A CB  1 
ATOM 473  C CG  . GLN A 1 153 ? 97.654  71.578  100.873 1.00 69.87 ? 153 GLN A CG  1 
ATOM 474  C CD  . GLN A 1 153 ? 96.189  71.223  100.623 1.00 65.86 ? 153 GLN A CD  1 
ATOM 475  O OE1 . GLN A 1 153 ? 95.801  70.830  99.539  1.00 59.86 ? 153 GLN A OE1 1 
ATOM 476  N NE2 . GLN A 1 153 ? 95.325  71.359  101.610 1.00 57.47 ? 153 GLN A NE2 1 
ATOM 477  N N   . SER A 1 154 ? 101.718 69.479  100.919 1.00 82.31 ? 154 SER A N   1 
ATOM 478  C CA  . SER A 1 154 ? 102.736 68.434  100.784 1.00 81.70 ? 154 SER A CA  1 
ATOM 479  C C   . SER A 1 154 ? 102.175 67.037  100.480 1.00 81.92 ? 154 SER A C   1 
ATOM 480  O O   . SER A 1 154 ? 102.913 66.159  100.058 1.00 75.37 ? 154 SER A O   1 
ATOM 481  C CB  . SER A 1 154 ? 103.560 68.370  102.079 1.00 77.48 ? 154 SER A CB  1 
ATOM 482  O OG  . SER A 1 154 ? 102.726 68.227  103.210 1.00 68.91 ? 154 SER A OG  1 
ATOM 483  N N   . ASP A 1 155 ? 100.895 66.840  100.698 1.00 85.00 ? 155 ASP A N   1 
ATOM 484  C CA  . ASP A 1 155 ? 100.139 65.601  100.500 1.00 85.04 ? 155 ASP A CA  1 
ATOM 485  C C   . ASP A 1 155 ? 99.464  65.511  99.120  1.00 86.91 ? 155 ASP A C   1 
ATOM 486  O O   . ASP A 1 155 ? 98.813  64.513  98.809  1.00 83.78 ? 155 ASP A O   1 
ATOM 487  C CB  . ASP A 1 155 ? 99.141  65.458  101.657 1.00 80.57 ? 155 ASP A CB  1 
ATOM 488  C CG  . ASP A 1 155 ? 98.165  66.645  101.813 1.00 71.97 ? 155 ASP A CG  1 
ATOM 489  O OD1 . ASP A 1 155 ? 98.473  67.752  101.328 1.00 63.73 ? 155 ASP A OD1 1 
ATOM 490  O OD2 . ASP A 1 155 ? 97.129  66.444  102.476 1.00 65.29 ? 155 ASP A OD2 1 
ATOM 491  N N   . LEU A 1 156 ? 99.665  66.515  98.265  1.00 88.65 ? 156 LEU A N   1 
ATOM 492  C CA  . LEU A 1 156 ? 99.236  66.506  96.878  1.00 90.06 ? 156 LEU A CA  1 
ATOM 493  C C   . LEU A 1 156 ? 100.381 66.085  95.950  1.00 91.00 ? 156 LEU A C   1 
ATOM 494  O O   . LEU A 1 156 ? 101.442 66.707  95.901  1.00 89.35 ? 156 LEU A O   1 
ATOM 495  C CB  . LEU A 1 156 ? 98.682  67.886  96.472  1.00 88.60 ? 156 LEU A CB  1 
ATOM 496  C CG  . LEU A 1 156 ? 97.351  68.269  97.156  1.00 86.75 ? 156 LEU A CG  1 
ATOM 497  C CD1 . LEU A 1 156 ? 96.941  69.664  96.691  1.00 82.96 ? 156 LEU A CD1 1 
ATOM 498  C CD2 . LEU A 1 156 ? 96.228  67.295  96.805  1.00 82.92 ? 156 LEU A CD2 1 
ATOM 499  N N   . ILE A 1 157 ? 100.115 65.066  95.136  1.00 92.54 ? 157 ILE A N   1 
ATOM 500  C CA  . ILE A 1 157 ? 100.935 64.764  93.965  1.00 92.94 ? 157 ILE A CA  1 
ATOM 501  C C   . ILE A 1 157 ? 100.664 65.853  92.922  1.00 93.25 ? 157 ILE A C   1 
ATOM 502  O O   . ILE A 1 157 ? 99.507  66.127  92.606  1.00 92.34 ? 157 ILE A O   1 
ATOM 503  C CB  . ILE A 1 157 ? 100.640 63.353  93.423  1.00 92.21 ? 157 ILE A CB  1 
ATOM 504  C CG1 . ILE A 1 157 ? 100.913 62.290  94.510  1.00 89.84 ? 157 ILE A CG1 1 
ATOM 505  C CG2 . ILE A 1 157 ? 101.485 63.071  92.163  1.00 89.69 ? 157 ILE A CG2 1 
ATOM 506  C CD1 . ILE A 1 157 ? 100.462 60.877  94.137  1.00 84.03 ? 157 ILE A CD1 1 
ATOM 507  N N   . GLN A 1 158 ? 101.720 66.436  92.368  1.00 93.61 ? 158 GLN A N   1 
ATOM 508  C CA  . GLN A 1 158 ? 101.609 67.516  91.394  1.00 93.14 ? 158 GLN A CA  1 
ATOM 509  C C   . GLN A 1 158 ? 102.517 67.304  90.180  1.00 93.13 ? 158 GLN A C   1 
ATOM 510  O O   . GLN A 1 158 ? 103.607 66.752  90.269  1.00 91.22 ? 158 GLN A O   1 
ATOM 511  C CB  . GLN A 1 158 ? 101.846 68.880  92.070  1.00 90.29 ? 158 GLN A CB  1 
ATOM 512  C CG  . GLN A 1 158 ? 103.204 69.011  92.770  1.00 83.90 ? 158 GLN A CG  1 
ATOM 513  C CD  . GLN A 1 158 ? 103.414 70.418  93.331  1.00 85.88 ? 158 GLN A CD  1 
ATOM 514  O OE1 . GLN A 1 158 ? 103.535 71.372  92.580  1.00 77.37 ? 158 GLN A OE1 1 
ATOM 515  N NE2 . GLN A 1 158 ? 103.479 70.576  94.631  1.00 76.74 ? 158 GLN A NE2 1 
ATOM 516  N N   . ARG A 1 159 ? 102.053 67.778  89.008  1.00 92.48 ? 159 ARG A N   1 
ATOM 517  C CA  . ARG A 1 159 ? 102.838 67.885  87.778  1.00 91.95 ? 159 ARG A CA  1 
ATOM 518  C C   . ARG A 1 159 ? 102.641 69.271  87.180  1.00 93.03 ? 159 ARG A C   1 
ATOM 519  O O   . ARG A 1 159 ? 101.501 69.683  86.983  1.00 91.44 ? 159 ARG A O   1 
ATOM 520  C CB  . ARG A 1 159 ? 102.441 66.811  86.765  1.00 88.82 ? 159 ARG A CB  1 
ATOM 521  C CG  . ARG A 1 159 ? 102.918 65.416  87.159  1.00 79.55 ? 159 ARG A CG  1 
ATOM 522  C CD  . ARG A 1 159 ? 102.731 64.461  85.970  1.00 75.63 ? 159 ARG A CD  1 
ATOM 523  N NE  . ARG A 1 159 ? 103.230 63.110  86.245  1.00 70.58 ? 159 ARG A NE  1 
ATOM 524  C CZ  . ARG A 1 159 ? 103.312 62.116  85.366  1.00 63.87 ? 159 ARG A CZ  1 
ATOM 525  N NH1 . ARG A 1 159 ? 102.978 62.283  84.121  1.00 58.37 ? 159 ARG A NH1 1 
ATOM 526  N NH2 . ARG A 1 159 ? 103.729 60.947  85.738  1.00 57.98 ? 159 ARG A NH2 1 
ATOM 527  N N   . LYS A 1 160 ? 103.740 69.934  86.825  1.00 90.60 ? 160 LYS A N   1 
ATOM 528  C CA  . LYS A 1 160 ? 103.687 71.129  85.982  1.00 90.38 ? 160 LYS A CA  1 
ATOM 529  C C   . LYS A 1 160 ? 103.072 70.762  84.632  1.00 90.16 ? 160 LYS A C   1 
ATOM 530  O O   . LYS A 1 160 ? 103.447 69.743  84.048  1.00 88.40 ? 160 LYS A O   1 
ATOM 531  C CB  . LYS A 1 160 ? 105.093 71.738  85.849  1.00 88.35 ? 160 LYS A CB  1 
ATOM 532  C CG  . LYS A 1 160 ? 105.098 72.981  84.937  1.00 83.85 ? 160 LYS A CG  1 
ATOM 533  C CD  . LYS A 1 160 ? 106.447 73.705  84.922  1.00 79.56 ? 160 LYS A CD  1 
ATOM 534  C CE  . LYS A 1 160 ? 106.390 74.777  83.822  1.00 71.32 ? 160 LYS A CE  1 
ATOM 535  N NZ  . LYS A 1 160 ? 107.455 75.802  83.934  1.00 64.72 ? 160 LYS A NZ  1 
ATOM 536  N N   . LEU A 1 161 ? 102.146 71.578  84.148  1.00 92.17 ? 161 LEU A N   1 
ATOM 537  C CA  . LEU A 1 161 ? 101.506 71.420  82.844  1.00 92.25 ? 161 LEU A CA  1 
ATOM 538  C C   . LEU A 1 161 ? 102.183 72.311  81.803  1.00 90.85 ? 161 LEU A C   1 
ATOM 539  O O   . LEU A 1 161 ? 103.098 71.858  81.115  1.00 88.08 ? 161 LEU A O   1 
ATOM 540  C CB  . LEU A 1 161 ? 99.989  71.668  82.964  1.00 92.65 ? 161 LEU A CB  1 
ATOM 541  C CG  . LEU A 1 161 ? 99.213  70.633  83.796  1.00 93.03 ? 161 LEU A CG  1 
ATOM 542  C CD1 . LEU A 1 161 ? 97.741  71.056  83.858  1.00 90.52 ? 161 LEU A CD1 1 
ATOM 543  C CD2 . LEU A 1 161 ? 99.293  69.232  83.201  1.00 90.40 ? 161 LEU A CD2 1 
ATOM 544  N N   . PHE A 1 162 ? 101.775 73.568  81.707  1.00 91.07 ? 162 PHE A N   1 
ATOM 545  C CA  . PHE A 1 162 ? 102.291 74.554  80.761  1.00 90.88 ? 162 PHE A CA  1 
ATOM 546  C C   . PHE A 1 162 ? 102.507 75.904  81.457  1.00 91.46 ? 162 PHE A C   1 
ATOM 547  O O   . PHE A 1 162 ? 101.953 76.163  82.527  1.00 90.78 ? 162 PHE A O   1 
ATOM 548  C CB  . PHE A 1 162 ? 101.343 74.673  79.556  1.00 89.11 ? 162 PHE A CB  1 
ATOM 549  C CG  . PHE A 1 162 ? 99.887  74.900  79.906  1.00 89.09 ? 162 PHE A CG  1 
ATOM 550  C CD1 . PHE A 1 162 ? 99.002  73.804  79.963  1.00 82.84 ? 162 PHE A CD1 1 
ATOM 551  C CD2 . PHE A 1 162 ? 99.398  76.194  80.163  1.00 83.20 ? 162 PHE A CD2 1 
ATOM 552  C CE1 . PHE A 1 162 ? 97.643  74.007  80.271  1.00 79.92 ? 162 PHE A CE1 1 
ATOM 553  C CE2 . PHE A 1 162 ? 98.045  76.395  80.473  1.00 80.18 ? 162 PHE A CE2 1 
ATOM 554  C CZ  . PHE A 1 162 ? 97.164  75.303  80.530  1.00 82.97 ? 162 PHE A CZ  1 
ATOM 555  N N   . THR A 1 163 ? 103.331 76.739  80.832  1.00 90.33 ? 163 THR A N   1 
ATOM 556  C CA  . THR A 1 163 ? 103.496 78.137  81.227  1.00 90.15 ? 163 THR A CA  1 
ATOM 557  C C   . THR A 1 163 ? 102.451 78.981  80.513  1.00 89.94 ? 163 THR A C   1 
ATOM 558  O O   . THR A 1 163 ? 102.238 78.806  79.312  1.00 89.02 ? 163 THR A O   1 
ATOM 559  C CB  . THR A 1 163 ? 104.915 78.627  80.912  1.00 88.91 ? 163 THR A CB  1 
ATOM 560  O OG1 . THR A 1 163 ? 105.861 77.769  81.514  1.00 84.20 ? 163 THR A OG1 1 
ATOM 561  C CG2 . THR A 1 163 ? 105.178 80.030  81.441  1.00 83.75 ? 163 THR A CG2 1 
ATOM 562  N N   . VAL A 1 164 ? 101.804 79.872  81.242  1.00 92.33 ? 164 VAL A N   1 
ATOM 563  C CA  . VAL A 1 164 ? 100.820 80.822  80.721  1.00 92.49 ? 164 VAL A CA  1 
ATOM 564  C C   . VAL A 1 164 ? 101.486 82.173  80.539  1.00 92.38 ? 164 VAL A C   1 
ATOM 565  O O   . VAL A 1 164 ? 102.142 82.676  81.454  1.00 91.55 ? 164 VAL A O   1 
ATOM 566  C CB  . VAL A 1 164 ? 99.619  80.947  81.667  1.00 92.00 ? 164 VAL A CB  1 
ATOM 567  C CG1 . VAL A 1 164 ? 98.574  81.924  81.121  1.00 88.99 ? 164 VAL A CG1 1 
ATOM 568  C CG2 . VAL A 1 164 ? 98.936  79.591  81.892  1.00 89.31 ? 164 VAL A CG2 1 
ATOM 569  N N   . HIS A 1 165 ? 101.282 82.762  79.371  1.00 91.48 ? 165 HIS A N   1 
ATOM 570  C CA  . HIS A 1 165 ? 101.687 84.124  79.072  1.00 90.86 ? 165 HIS A CA  1 
ATOM 571  C C   . HIS A 1 165 ? 100.466 85.044  79.033  1.00 91.64 ? 165 HIS A C   1 
ATOM 572  O O   . HIS A 1 165 ? 99.408  84.682  78.509  1.00 90.99 ? 165 HIS A O   1 
ATOM 573  C CB  . HIS A 1 165 ? 102.492 84.151  77.771  1.00 88.99 ? 165 HIS A CB  1 
ATOM 574  C CG  . HIS A 1 165 ? 103.769 83.347  77.873  1.00 86.09 ? 165 HIS A CG  1 
ATOM 575  N ND1 . HIS A 1 165 ? 104.944 83.787  78.448  1.00 77.03 ? 165 HIS A ND1 1 
ATOM 576  C CD2 . HIS A 1 165 ? 103.976 82.051  77.479  1.00 76.65 ? 165 HIS A CD2 1 
ATOM 577  C CE1 . HIS A 1 165 ? 105.832 82.776  78.386  1.00 77.35 ? 165 HIS A CE1 1 
ATOM 578  N NE2 . HIS A 1 165 ? 105.285 81.705  77.813  1.00 78.08 ? 165 HIS A NE2 1 
ATOM 579  N N   . MET A 1 166 ? 100.615 86.234  79.594  1.00 92.52 ? 166 MET A N   1 
ATOM 580  C CA  . MET A 1 166 ? 99.638  87.310  79.502  1.00 92.99 ? 166 MET A CA  1 
ATOM 581  C C   . MET A 1 166 ? 100.078 88.273  78.403  1.00 92.97 ? 166 MET A C   1 
ATOM 582  O O   . MET A 1 166 ? 101.231 88.684  78.356  1.00 91.39 ? 166 MET A O   1 
ATOM 583  C CB  . MET A 1 166 ? 99.530  88.048  80.845  1.00 92.23 ? 166 MET A CB  1 
ATOM 584  C CG  . MET A 1 166 ? 99.053  87.170  82.001  1.00 87.98 ? 166 MET A CG  1 
ATOM 585  S SD  . MET A 1 166 ? 97.294  86.708  81.960  1.00 86.81 ? 166 MET A SD  1 
ATOM 586  C CE  . MET A 1 166 ? 96.519  88.279  82.429  1.00 78.80 ? 166 MET A CE  1 
ATOM 587  N N   . HIS A 1 167 ? 99.148  88.660  77.533  1.00 93.52 ? 167 HIS A N   1 
ATOM 588  C CA  . HIS A 1 167 ? 99.377  89.670  76.505  1.00 93.40 ? 167 HIS A CA  1 
ATOM 589  C C   . HIS A 1 167 ? 98.237  90.678  76.468  1.00 94.40 ? 167 HIS A C   1 
ATOM 590  O O   . HIS A 1 167 ? 97.144  90.434  76.974  1.00 94.07 ? 167 HIS A O   1 
ATOM 591  C CB  . HIS A 1 167 ? 99.596  88.996  75.147  1.00 91.71 ? 167 HIS A CB  1 
ATOM 592  C CG  . HIS A 1 167 ? 100.814 88.137  75.076  1.00 89.29 ? 167 HIS A CG  1 
ATOM 593  N ND1 . HIS A 1 167 ? 102.118 88.580  75.060  1.00 78.30 ? 167 HIS A ND1 1 
ATOM 594  C CD2 . HIS A 1 167 ? 100.866 86.760  75.015  1.00 77.49 ? 167 HIS A CD2 1 
ATOM 595  C CE1 . HIS A 1 167 ? 102.932 87.504  74.986  1.00 78.16 ? 167 HIS A CE1 1 
ATOM 596  N NE2 . HIS A 1 167 ? 102.204 86.380  74.953  1.00 79.76 ? 167 HIS A NE2 1 
ATOM 597  N N   . VAL A 1 168 ? 98.518  91.825  75.861  1.00 94.57 ? 168 VAL A N   1 
ATOM 598  C CA  . VAL A 1 168 ? 97.539  92.890  75.666  1.00 95.27 ? 168 VAL A CA  1 
ATOM 599  C C   . VAL A 1 168 ? 96.935  92.761  74.273  1.00 95.14 ? 168 VAL A C   1 
ATOM 600  O O   . VAL A 1 168 ? 97.657  92.574  73.298  1.00 94.24 ? 168 VAL A O   1 
ATOM 601  C CB  . VAL A 1 168 ? 98.170  94.272  75.900  1.00 95.18 ? 168 VAL A CB  1 
ATOM 602  C CG1 . VAL A 1 168 ? 97.114  95.379  75.803  1.00 92.88 ? 168 VAL A CG1 1 
ATOM 603  C CG2 . VAL A 1 168 ? 98.809  94.358  77.289  1.00 92.57 ? 168 VAL A CG2 1 
ATOM 604  N N   . TYR A 1 169 ? 95.606  92.877  74.184  1.00 95.22 ? 169 TYR A N   1 
ATOM 605  C CA  . TYR A 1 169 ? 94.860  92.673  72.945  1.00 95.31 ? 169 TYR A CA  1 
ATOM 606  C C   . TYR A 1 169 ? 93.832  93.782  72.708  1.00 95.96 ? 169 TYR A C   1 
ATOM 607  O O   . TYR A 1 169 ? 93.267  94.342  73.644  1.00 95.64 ? 169 TYR A O   1 
ATOM 608  C CB  . TYR A 1 169 ? 94.163  91.315  72.975  1.00 94.58 ? 169 TYR A CB  1 
ATOM 609  C CG  . TYR A 1 169 ? 95.088  90.124  73.083  1.00 94.06 ? 169 TYR A CG  1 
ATOM 610  C CD1 . TYR A 1 169 ? 95.669  89.569  71.934  1.00 91.27 ? 169 TYR A CD1 1 
ATOM 611  C CD2 . TYR A 1 169 ? 95.384  89.567  74.343  1.00 91.07 ? 169 TYR A CD2 1 
ATOM 612  C CE1 . TYR A 1 169 ? 96.531  88.461  72.023  1.00 89.73 ? 169 TYR A CE1 1 
ATOM 613  C CE2 . TYR A 1 169 ? 96.249  88.460  74.450  1.00 89.69 ? 169 TYR A CE2 1 
ATOM 614  C CZ  . TYR A 1 169 ? 96.822  87.908  73.290  1.00 91.24 ? 169 TYR A CZ  1 
ATOM 615  O OH  . TYR A 1 169 ? 97.658  86.829  73.384  1.00 89.36 ? 169 TYR A OH  1 
ATOM 616  N N   . ALA A 1 170 ? 93.542  94.023  71.438  1.00 94.45 ? 170 ALA A N   1 
ATOM 617  C CA  . ALA A 1 170 ? 92.397  94.807  71.001  1.00 94.57 ? 170 ALA A CA  1 
ATOM 618  C C   . ALA A 1 170 ? 91.749  94.174  69.754  1.00 94.12 ? 170 ALA A C   1 
ATOM 619  O O   . ALA A 1 170 ? 92.413  93.486  68.968  1.00 93.03 ? 170 ALA A O   1 
ATOM 620  C CB  . ALA A 1 170 ? 92.827  96.250  70.745  1.00 94.41 ? 170 ALA A CB  1 
ATOM 621  N N   . ALA A 1 171 ? 90.463  94.416  69.560  1.00 93.08 ? 171 ALA A N   1 
ATOM 622  C CA  . ALA A 1 171 ? 89.765  94.004  68.344  1.00 92.48 ? 171 ALA A CA  1 
ATOM 623  C C   . ALA A 1 171 ? 90.109  94.938  67.173  1.00 92.02 ? 171 ALA A C   1 
ATOM 624  O O   . ALA A 1 171 ? 90.276  96.143  67.381  1.00 90.97 ? 171 ALA A O   1 
ATOM 625  C CB  . ALA A 1 171 ? 88.262  93.988  68.606  1.00 91.47 ? 171 ALA A CB  1 
ATOM 626  N N   . PRO A 1 172 ? 90.082  94.442  65.932  1.00 88.95 ? 172 PRO A N   1 
ATOM 627  C CA  . PRO A 1 172 ? 90.138  95.286  64.735  1.00 87.04 ? 172 PRO A CA  1 
ATOM 628  C C   . PRO A 1 172 ? 89.144  96.452  64.773  1.00 86.92 ? 172 PRO A C   1 
ATOM 629  O O   . PRO A 1 172 ? 89.499  97.589  64.509  1.00 85.89 ? 172 PRO A O   1 
ATOM 630  C CB  . PRO A 1 172 ? 89.843  94.336  63.570  1.00 84.86 ? 172 PRO A CB  1 
ATOM 631  C CG  . PRO A 1 172 ? 90.356  92.996  64.072  1.00 83.15 ? 172 PRO A CG  1 
ATOM 632  C CD  . PRO A 1 172 ? 90.054  93.033  65.565  1.00 85.64 ? 172 PRO A CD  1 
ATOM 633  N N   . SER A 1 173 ? 87.912  96.194  65.210  1.00 86.61 ? 173 SER A N   1 
ATOM 634  C CA  . SER A 1 173 ? 86.859  97.219  65.313  1.00 85.77 ? 173 SER A CA  1 
ATOM 635  C C   . SER A 1 173 ? 87.157  98.324  66.338  1.00 86.39 ? 173 SER A C   1 
ATOM 636  O O   . SER A 1 173 ? 86.623  99.429  66.215  1.00 85.25 ? 173 SER A O   1 
ATOM 637  C CB  . SER A 1 173 ? 85.524  96.553  65.659  1.00 83.97 ? 173 SER A CB  1 
ATOM 638  O OG  . SER A 1 173 ? 85.559  95.979  66.948  1.00 79.95 ? 173 SER A OG  1 
ATOM 639  N N   . TYR A 1 174 ? 87.979  98.052  67.345  1.00 90.75 ? 174 TYR A N   1 
ATOM 640  C CA  . TYR A 1 174 ? 88.468  99.058  68.290  1.00 91.91 ? 174 TYR A CA  1 
ATOM 641  C C   . TYR A 1 174 ? 89.596  99.887  67.662  1.00 91.09 ? 174 TYR A C   1 
ATOM 642  O O   . TYR A 1 174 ? 89.491  101.113 67.620  1.00 89.34 ? 174 TYR A O   1 
ATOM 643  C CB  . TYR A 1 174 ? 88.913  98.385  69.595  1.00 93.06 ? 174 TYR A CB  1 
ATOM 644  C CG  . TYR A 1 174 ? 89.475  99.367  70.596  1.00 94.33 ? 174 TYR A CG  1 
ATOM 645  C CD1 . TYR A 1 174 ? 90.843  99.693  70.583  1.00 92.99 ? 174 TYR A CD1 1 
ATOM 646  C CD2 . TYR A 1 174 ? 88.618  100.024 71.509  1.00 93.10 ? 174 TYR A CD2 1 
ATOM 647  C CE1 . TYR A 1 174 ? 91.353  100.673 71.458  1.00 93.65 ? 174 TYR A CE1 1 
ATOM 648  C CE2 . TYR A 1 174 ? 89.111  100.997 72.384  1.00 93.47 ? 174 TYR A CE2 1 
ATOM 649  C CZ  . TYR A 1 174 ? 90.480  101.331 72.351  1.00 95.20 ? 174 TYR A CZ  1 
ATOM 650  O OH  . TYR A 1 174 ? 90.961  102.307 73.177  1.00 95.01 ? 174 TYR A OH  1 
ATOM 651  N N   . ILE A 1 175 ? 90.614  99.221  67.124  1.00 90.59 ? 175 ILE A N   1 
ATOM 652  C CA  . ILE A 1 175 ? 91.772  99.861  66.479  1.00 89.58 ? 175 ILE A CA  1 
ATOM 653  C C   . ILE A 1 175 ? 91.341  100.765 65.318  1.00 88.19 ? 175 ILE A C   1 
ATOM 654  O O   . ILE A 1 175 ? 91.744  101.925 65.264  1.00 86.38 ? 175 ILE A O   1 
ATOM 655  C CB  . ILE A 1 175 ? 92.799  98.802  66.039  1.00 89.00 ? 175 ILE A CB  1 
ATOM 656  C CG1 . ILE A 1 175 ? 93.349  97.986  67.232  1.00 86.46 ? 175 ILE A CG1 1 
ATOM 657  C CG2 . ILE A 1 175 ? 93.959  99.421  65.243  1.00 86.21 ? 175 ILE A CG2 1 
ATOM 658  C CD1 . ILE A 1 175 ? 94.095  98.782  68.302  1.00 79.67 ? 175 ILE A CD1 1 
ATOM 659  N N   . ASN A 1 176 ? 90.429  100.287 64.480  1.00 85.71 ? 176 ASN A N   1 
ATOM 660  C CA  . ASN A 1 176 ? 89.879  101.055 63.360  1.00 82.94 ? 176 ASN A CA  1 
ATOM 661  C C   . ASN A 1 176 ? 89.215  102.379 63.801  1.00 82.86 ? 176 ASN A C   1 
ATOM 662  O O   . ASN A 1 176 ? 89.070  103.287 62.983  1.00 81.08 ? 176 ASN A O   1 
ATOM 663  C CB  . ASN A 1 176 ? 88.850  100.190 62.614  1.00 80.15 ? 176 ASN A CB  1 
ATOM 664  C CG  . ASN A 1 176 ? 89.424  98.989  61.864  1.00 77.66 ? 176 ASN A CG  1 
ATOM 665  O OD1 . ASN A 1 176 ? 90.606  98.856  61.628  1.00 71.99 ? 176 ASN A OD1 1 
ATOM 666  N ND2 . ASN A 1 176 ? 88.572  98.071  61.436  1.00 70.87 ? 176 ASN A ND2 1 
ATOM 667  N N   . ARG A 1 177 ? 88.773  102.494 65.048  1.00 85.64 ? 177 ARG A N   1 
ATOM 668  C CA  . ARG A 1 177 ? 88.092  103.690 65.588  1.00 84.97 ? 177 ARG A CA  1 
ATOM 669  C C   . ARG A 1 177 ? 88.976  104.549 66.488  1.00 86.04 ? 177 ARG A C   1 
ATOM 670  O O   . ARG A 1 177 ? 88.779  105.762 66.518  1.00 84.21 ? 177 ARG A O   1 
ATOM 671  C CB  . ARG A 1 177 ? 86.832  103.275 66.356  1.00 82.41 ? 177 ARG A CB  1 
ATOM 672  C CG  . ARG A 1 177 ? 85.652  102.975 65.421  1.00 74.44 ? 177 ARG A CG  1 
ATOM 673  C CD  . ARG A 1 177 ? 84.379  102.686 66.229  1.00 71.84 ? 177 ARG A CD  1 
ATOM 674  N NE  . ARG A 1 177 ? 84.488  101.404 66.951  1.00 63.00 ? 177 ARG A NE  1 
ATOM 675  C CZ  . ARG A 1 177 ? 83.668  100.956 67.893  1.00 56.20 ? 177 ARG A CZ  1 
ATOM 676  N NH1 . ARG A 1 177 ? 82.637  101.642 68.290  1.00 51.45 ? 177 ARG A NH1 1 
ATOM 677  N NH2 . ARG A 1 177 ? 83.878  99.787  68.436  1.00 48.34 ? 177 ARG A NH2 1 
ATOM 678  N N   . HIS A 1 178 ? 89.869  103.939 67.243  1.00 90.58 ? 178 HIS A N   1 
ATOM 679  C CA  . HIS A 1 178 ? 90.627  104.593 68.310  1.00 90.98 ? 178 HIS A CA  1 
ATOM 680  C C   . HIS A 1 178 ? 92.144  104.644 68.060  1.00 91.03 ? 178 HIS A C   1 
ATOM 681  O O   . HIS A 1 178 ? 92.852  105.308 68.812  1.00 88.39 ? 178 HIS A O   1 
ATOM 682  C CB  . HIS A 1 178 ? 90.284  103.925 69.644  1.00 90.95 ? 178 HIS A CB  1 
ATOM 683  C CG  . HIS A 1 178 ? 88.834  104.079 70.040  1.00 90.92 ? 178 HIS A CG  1 
ATOM 684  N ND1 . HIS A 1 178 ? 88.273  105.240 70.546  1.00 79.78 ? 178 HIS A ND1 1 
ATOM 685  C CD2 . HIS A 1 178 ? 87.830  103.153 69.949  1.00 79.46 ? 178 HIS A CD2 1 
ATOM 686  C CE1 . HIS A 1 178 ? 86.976  105.005 70.755  1.00 82.08 ? 178 HIS A CE1 1 
ATOM 687  N NE2 . HIS A 1 178 ? 86.661  103.749 70.407  1.00 84.29 ? 178 HIS A NE2 1 
ATOM 688  N N   . GLY A 1 179 ? 92.626  103.984 67.017  1.00 89.39 ? 179 GLY A N   1 
ATOM 689  C CA  . GLY A 1 179 ? 94.052  103.832 66.757  1.00 89.79 ? 179 GLY A CA  1 
ATOM 690  C C   . GLY A 1 179 ? 94.699  102.779 67.657  1.00 91.11 ? 179 GLY A C   1 
ATOM 691  O O   . GLY A 1 179 ? 94.072  102.216 68.556  1.00 90.44 ? 179 GLY A O   1 
ATOM 692  N N   . GLU A 1 180 ? 95.983  102.515 67.416  1.00 91.44 ? 180 GLU A N   1 
ATOM 693  C CA  . GLU A 1 180 ? 96.773  101.548 68.171  1.00 91.36 ? 180 GLU A CA  1 
ATOM 694  C C   . GLU A 1 180 ? 97.732  102.264 69.137  1.00 92.08 ? 180 GLU A C   1 
ATOM 695  O O   . GLU A 1 180 ? 98.525  103.099 68.697  1.00 90.70 ? 180 GLU A O   1 
ATOM 696  C CB  . GLU A 1 180 ? 97.529  100.635 67.187  1.00 88.57 ? 180 GLU A CB  1 
ATOM 697  C CG  . GLU A 1 180 ? 98.255  99.497  67.920  1.00 80.81 ? 180 GLU A CG  1 
ATOM 698  C CD  . GLU A 1 180 ? 98.970  98.499  67.000  1.00 80.08 ? 180 GLU A CD  1 
ATOM 699  O OE1 . GLU A 1 180 ? 99.671  97.621  67.557  1.00 72.76 ? 180 GLU A OE1 1 
ATOM 700  O OE2 . GLU A 1 180 ? 98.819  98.596  65.762  1.00 74.02 ? 180 GLU A OE2 1 
ATOM 701  N N   . PRO A 1 181 ? 97.700  101.953 70.441  1.00 93.52 ? 181 PRO A N   1 
ATOM 702  C CA  . PRO A 1 181 ? 98.676  102.487 71.384  1.00 93.78 ? 181 PRO A CA  1 
ATOM 703  C C   . PRO A 1 181 ? 100.059 101.874 71.106  1.00 93.18 ? 181 PRO A C   1 
ATOM 704  O O   . PRO A 1 181 ? 100.198 100.667 70.916  1.00 91.03 ? 181 PRO A O   1 
ATOM 705  C CB  . PRO A 1 181 ? 98.157  102.109 72.768  1.00 93.17 ? 181 PRO A CB  1 
ATOM 706  C CG  . PRO A 1 181 ? 97.381  100.817 72.515  1.00 91.80 ? 181 PRO A CG  1 
ATOM 707  C CD  . PRO A 1 181 ? 96.801  101.026 71.117  1.00 93.50 ? 181 PRO A CD  1 
ATOM 708  N N   . GLN A 1 182 ? 101.091 102.717 71.139  1.00 91.52 ? 182 GLN A N   1 
ATOM 709  C CA  . GLN A 1 182 ? 102.476 102.316 70.886  1.00 89.88 ? 182 GLN A CA  1 
ATOM 710  C C   . GLN A 1 182 ? 103.289 102.076 72.170  1.00 89.91 ? 182 GLN A C   1 
ATOM 711  O O   . GLN A 1 182 ? 104.374 101.495 72.128  1.00 86.18 ? 182 GLN A O   1 
ATOM 712  C CB  . GLN A 1 182 ? 103.152 103.389 70.007  1.00 87.25 ? 182 GLN A CB  1 
ATOM 713  C CG  . GLN A 1 182 ? 102.460 103.599 68.642  1.00 83.51 ? 182 GLN A CG  1 
ATOM 714  C CD  . GLN A 1 182 ? 102.543 102.349 67.747  1.00 76.92 ? 182 GLN A CD  1 
ATOM 715  O OE1 . GLN A 1 182 ? 103.612 101.844 67.475  1.00 68.10 ? 182 GLN A OE1 1 
ATOM 716  N NE2 . GLN A 1 182 ? 101.424 101.825 67.302  1.00 65.78 ? 182 GLN A NE2 1 
ATOM 717  N N   . SER A 1 183 ? 102.774 102.533 73.316  1.00 92.44 ? 183 SER A N   1 
ATOM 718  C CA  . SER A 1 183 ? 103.449 102.427 74.615  1.00 92.95 ? 183 SER A CA  1 
ATOM 719  C C   . SER A 1 183 ? 102.444 102.232 75.757  1.00 93.86 ? 183 SER A C   1 
ATOM 720  O O   . SER A 1 183 ? 101.234 102.382 75.591  1.00 92.99 ? 183 SER A O   1 
ATOM 721  C CB  . SER A 1 183 ? 104.290 103.692 74.849  1.00 91.24 ? 183 SER A CB  1 
ATOM 722  O OG  . SER A 1 183 ? 103.460 104.813 75.083  1.00 87.36 ? 183 SER A OG  1 
ATOM 723  N N   . VAL A 1 184 ? 102.948 101.916 76.936  1.00 93.83 ? 184 VAL A N   1 
ATOM 724  C CA  . VAL A 1 184 ? 102.119 101.856 78.148  1.00 94.25 ? 184 VAL A CA  1 
ATOM 725  C C   . VAL A 1 184 ? 101.508 103.220 78.479  1.00 94.49 ? 184 VAL A C   1 
ATOM 726  O O   . VAL A 1 184 ? 100.362 103.285 78.916  1.00 93.14 ? 184 VAL A O   1 
ATOM 727  C CB  . VAL A 1 184 ? 102.950 101.321 79.339  1.00 92.96 ? 184 VAL A CB  1 
ATOM 728  C CG1 . VAL A 1 184 ? 102.220 101.446 80.679  1.00 87.26 ? 184 VAL A CG1 1 
ATOM 729  C CG2 . VAL A 1 184 ? 103.288 99.837  79.133  1.00 87.19 ? 184 VAL A CG2 1 
ATOM 730  N N   . GLU A 1 185 ? 102.242 104.309 78.241  1.00 93.71 ? 185 GLU A N   1 
ATOM 731  C CA  . GLU A 1 185 ? 101.747 105.674 78.507  1.00 93.39 ? 185 GLU A CA  1 
ATOM 732  C C   . GLU A 1 185 ? 100.590 106.065 77.581  1.00 93.97 ? 185 GLU A C   1 
ATOM 733  O O   . GLU A 1 185 ? 99.665  106.744 78.011  1.00 92.51 ? 185 GLU A O   1 
ATOM 734  C CB  . GLU A 1 185 ? 102.912 106.662 78.399  1.00 91.89 ? 185 GLU A CB  1 
ATOM 735  C CG  . GLU A 1 185 ? 103.805 106.612 79.651  1.00 80.26 ? 185 GLU A CG  1 
ATOM 736  C CD  . GLU A 1 185 ? 105.322 106.573 79.431  1.00 69.97 ? 185 GLU A CD  1 
ATOM 737  O OE1 . GLU A 1 185 ? 106.021 106.805 80.438  1.00 61.06 ? 185 GLU A OE1 1 
ATOM 738  O OE2 . GLU A 1 185 ? 105.767 106.261 78.309  1.00 60.29 ? 185 GLU A OE2 1 
ATOM 739  N N   . ASP A 1 186 ? 100.574 105.556 76.333  1.00 94.16 ? 186 ASP A N   1 
ATOM 740  C CA  . ASP A 1 186 ? 99.471  105.799 75.400  1.00 94.15 ? 186 ASP A CA  1 
ATOM 741  C C   . ASP A 1 186 ? 98.133  105.219 75.892  1.00 94.85 ? 186 ASP A C   1 
ATOM 742  O O   . ASP A 1 186 ? 97.072  105.715 75.509  1.00 93.69 ? 186 ASP A O   1 
ATOM 743  C CB  . ASP A 1 186 ? 99.801  105.233 74.016  1.00 92.64 ? 186 ASP A CB  1 
ATOM 744  C CG  . ASP A 1 186 ? 100.957 105.936 73.303  1.00 90.19 ? 186 ASP A CG  1 
ATOM 745  O OD1 . ASP A 1 186 ? 101.130 107.157 73.507  1.00 85.27 ? 186 ASP A OD1 1 
ATOM 746  O OD2 . ASP A 1 186 ? 101.650 105.225 72.529  1.00 85.48 ? 186 ASP A OD2 1 
ATOM 747  N N   . LEU A 1 187 ? 98.162  104.217 76.782  1.00 95.03 ? 187 LEU A N   1 
ATOM 748  C CA  . LEU A 1 187 ? 96.946  103.662 77.398  1.00 95.36 ? 187 LEU A CA  1 
ATOM 749  C C   . LEU A 1 187 ? 96.112  104.721 78.138  1.00 95.45 ? 187 LEU A C   1 
ATOM 750  O O   . LEU A 1 187 ? 94.918  104.524 78.327  1.00 94.23 ? 187 LEU A O   1 
ATOM 751  C CB  . LEU A 1 187 ? 97.309  102.539 78.383  1.00 95.02 ? 187 LEU A CB  1 
ATOM 752  C CG  . LEU A 1 187 ? 97.948  101.281 77.765  1.00 94.55 ? 187 LEU A CG  1 
ATOM 753  C CD1 . LEU A 1 187 ? 98.369  100.332 78.893  1.00 92.15 ? 187 LEU A CD1 1 
ATOM 754  C CD2 . LEU A 1 187 ? 96.974  100.537 76.856  1.00 91.49 ? 187 LEU A CD2 1 
ATOM 755  N N   . ASP A 1 188 ? 96.714  105.843 78.527  1.00 95.17 ? 188 ASP A N   1 
ATOM 756  C CA  . ASP A 1 188 ? 96.003  106.954 79.178  1.00 94.35 ? 188 ASP A CA  1 
ATOM 757  C C   . ASP A 1 188 ? 94.969  107.617 78.253  1.00 94.08 ? 188 ASP A C   1 
ATOM 758  O O   . ASP A 1 188 ? 93.998  108.203 78.727  1.00 90.81 ? 188 ASP A O   1 
ATOM 759  C CB  . ASP A 1 188 ? 97.023  107.991 79.690  1.00 92.87 ? 188 ASP A CB  1 
ATOM 760  C CG  . ASP A 1 188 ? 97.845  107.496 80.898  1.00 91.28 ? 188 ASP A CG  1 
ATOM 761  O OD1 . ASP A 1 188 ? 97.745  106.308 81.274  1.00 86.16 ? 188 ASP A OD1 1 
ATOM 762  O OD2 . ASP A 1 188 ? 98.498  108.331 81.553  1.00 85.62 ? 188 ASP A OD2 1 
ATOM 763  N N   . ASN A 1 189 ? 95.132  107.472 76.930  1.00 94.51 ? 189 ASN A N   1 
ATOM 764  C CA  . ASN A 1 189 ? 94.207  107.964 75.910  1.00 93.89 ? 189 ASN A CA  1 
ATOM 765  C C   . ASN A 1 189 ? 93.263  106.871 75.375  1.00 94.08 ? 189 ASN A C   1 
ATOM 766  O O   . ASN A 1 189 ? 92.473  107.131 74.464  1.00 90.96 ? 189 ASN A O   1 
ATOM 767  C CB  . ASN A 1 189 ? 95.020  108.606 74.782  1.00 92.21 ? 189 ASN A CB  1 
ATOM 768  C CG  . ASN A 1 189 ? 95.868  109.769 75.280  1.00 87.94 ? 189 ASN A CG  1 
ATOM 769  O OD1 . ASN A 1 189 ? 95.395  110.661 75.958  1.00 79.03 ? 189 ASN A OD1 1 
ATOM 770  N ND2 . ASN A 1 189 ? 97.136  109.776 74.940  1.00 76.26 ? 189 ASN A ND2 1 
ATOM 771  N N   . HIS A 1 190 ? 93.334  105.675 75.924  1.00 95.75 ? 190 HIS A N   1 
ATOM 772  C CA  . HIS A 1 190 ? 92.578  104.522 75.455  1.00 96.12 ? 190 HIS A CA  1 
ATOM 773  C C   . HIS A 1 190 ? 91.563  104.013 76.482  1.00 96.24 ? 190 HIS A C   1 
ATOM 774  O O   . HIS A 1 190 ? 91.595  104.336 77.664  1.00 94.84 ? 190 HIS A O   1 
ATOM 775  C CB  . HIS A 1 190 ? 93.556  103.434 75.005  1.00 95.79 ? 190 HIS A CB  1 
ATOM 776  C CG  . HIS A 1 190 ? 94.100  103.701 73.631  1.00 96.31 ? 190 HIS A CG  1 
ATOM 777  N ND1 . HIS A 1 190 ? 93.502  103.321 72.438  1.00 89.53 ? 190 HIS A ND1 1 
ATOM 778  C CD2 . HIS A 1 190 ? 95.238  104.398 73.302  1.00 89.45 ? 190 HIS A CD2 1 
ATOM 779  C CE1 . HIS A 1 190 ? 94.264  103.769 71.436  1.00 90.86 ? 190 HIS A CE1 1 
ATOM 780  N NE2 . HIS A 1 190 ? 95.324  104.428 71.921  1.00 91.80 ? 190 HIS A NE2 1 
ATOM 781  N N   . ARG A 1 191 ? 90.632  103.190 76.009  1.00 96.71 ? 191 ARG A N   1 
ATOM 782  C CA  . ARG A 1 191 ? 89.648  102.511 76.847  1.00 96.65 ? 191 ARG A CA  1 
ATOM 783  C C   . ARG A 1 191 ? 90.209  101.154 77.256  1.00 96.89 ? 191 ARG A C   1 
ATOM 784  O O   . ARG A 1 191 ? 90.452  100.314 76.392  1.00 95.87 ? 191 ARG A O   1 
ATOM 785  C CB  . ARG A 1 191 ? 88.322  102.361 76.099  1.00 95.43 ? 191 ARG A CB  1 
ATOM 786  C CG  . ARG A 1 191 ? 87.675  103.726 75.782  1.00 92.68 ? 191 ARG A CG  1 
ATOM 787  C CD  . ARG A 1 191 ? 86.385  103.510 74.992  1.00 89.54 ? 191 ARG A CD  1 
ATOM 788  N NE  . ARG A 1 191 ? 85.732  104.796 74.672  1.00 84.23 ? 191 ARG A NE  1 
ATOM 789  C CZ  . ARG A 1 191 ? 84.588  104.959 74.046  1.00 78.61 ? 191 ARG A CZ  1 
ATOM 790  N NH1 . ARG A 1 191 ? 83.895  103.943 73.620  1.00 73.50 ? 191 ARG A NH1 1 
ATOM 791  N NH2 . ARG A 1 191 ? 84.130  106.147 73.833  1.00 74.06 ? 191 ARG A NH2 1 
ATOM 792  N N   . ILE A 1 192 ? 90.380  100.937 78.548  1.00 96.95 ? 192 ILE A N   1 
ATOM 793  C CA  . ILE A 1 192 ? 90.866  99.662  79.073  1.00 96.94 ? 192 ILE A CA  1 
ATOM 794  C C   . ILE A 1 192 ? 89.733  98.831  79.680  1.00 97.26 ? 192 ILE A C   1 
ATOM 795  O O   . ILE A 1 192 ? 88.784  99.371  80.262  1.00 96.26 ? 192 ILE A O   1 
ATOM 796  C CB  . ILE A 1 192 ? 92.072  99.842  80.023  1.00 94.85 ? 192 ILE A CB  1 
ATOM 797  C CG1 . ILE A 1 192 ? 91.720  100.646 81.291  1.00 86.53 ? 192 ILE A CG1 1 
ATOM 798  C CG2 . ILE A 1 192 ? 93.243  100.493 79.248  1.00 82.43 ? 192 ILE A CG2 1 
ATOM 799  C CD1 . ILE A 1 192 ? 92.841  100.660 82.340  1.00 80.57 ? 192 ILE A CD1 1 
ATOM 800  N N   . ILE A 1 193 ? 89.847  97.519  79.525  1.00 96.71 ? 193 ILE A N   1 
ATOM 801  C CA  . ILE A 1 193 ? 88.974  96.513  80.125  1.00 96.94 ? 193 ILE A CA  1 
ATOM 802  C C   . ILE A 1 193 ? 89.822  95.699  81.100  1.00 96.31 ? 193 ILE A C   1 
ATOM 803  O O   . ILE A 1 193 ? 90.889  95.210  80.731  1.00 95.48 ? 193 ILE A O   1 
ATOM 804  C CB  . ILE A 1 193 ? 88.338  95.595  79.058  1.00 96.94 ? 193 ILE A CB  1 
ATOM 805  C CG1 . ILE A 1 193 ? 87.672  96.395  77.912  1.00 94.36 ? 193 ILE A CG1 1 
ATOM 806  C CG2 . ILE A 1 193 ? 87.310  94.660  79.718  1.00 93.70 ? 193 ILE A CG2 1 
ATOM 807  C CD1 . ILE A 1 193 ? 87.262  95.517  76.721  1.00 93.96 ? 193 ILE A CD1 1 
ATOM 808  N N   . SER A 1 194 ? 89.355  95.538  82.320  1.00 96.50 ? 194 SER A N   1 
ATOM 809  C CA  . SER A 1 194 ? 90.062  94.794  83.364  1.00 96.22 ? 194 SER A CA  1 
ATOM 810  C C   . SER A 1 194 ? 89.105  93.884  84.146  1.00 96.52 ? 194 SER A C   1 
ATOM 811  O O   . SER A 1 194 ? 87.901  93.824  83.875  1.00 94.66 ? 194 SER A O   1 
ATOM 812  C CB  . SER A 1 194 ? 90.831  95.769  84.261  1.00 93.63 ? 194 SER A CB  1 
ATOM 813  O OG  . SER A 1 194 ? 89.940  96.643  84.899  1.00 84.74 ? 194 SER A OG  1 
ATOM 814  N N   . PHE A 1 195 ? 89.654  93.135  85.088  1.00 95.63 ? 195 PHE A N   1 
ATOM 815  C CA  . PHE A 1 195 ? 88.881  92.180  85.886  1.00 95.37 ? 195 PHE A CA  1 
ATOM 816  C C   . PHE A 1 195 ? 88.111  92.884  87.013  1.00 94.82 ? 195 PHE A C   1 
ATOM 817  O O   . PHE A 1 195 ? 86.958  92.569  87.289  1.00 91.50 ? 195 PHE A O   1 
ATOM 818  C CB  . PHE A 1 195 ? 89.844  91.109  86.411  1.00 94.61 ? 195 PHE A CB  1 
ATOM 819  C CG  . PHE A 1 195 ? 89.169  89.880  86.978  1.00 95.62 ? 195 PHE A CG  1 
ATOM 820  C CD1 . PHE A 1 195 ? 88.794  89.828  88.341  1.00 92.37 ? 195 PHE A CD1 1 
ATOM 821  C CD2 . PHE A 1 195 ? 88.959  88.750  86.167  1.00 92.06 ? 195 PHE A CD2 1 
ATOM 822  C CE1 . PHE A 1 195 ? 88.223  88.670  88.873  1.00 91.63 ? 195 PHE A CE1 1 
ATOM 823  C CE2 . PHE A 1 195 ? 88.392  87.585  86.697  1.00 91.04 ? 195 PHE A CE2 1 
ATOM 824  C CZ  . PHE A 1 195 ? 88.027  87.537  88.058  1.00 93.65 ? 195 PHE A CZ  1 
ATOM 825  N N   . GLY A 1 196 ? 88.743  93.864  87.628  1.00 93.60 ? 196 GLY A N   1 
ATOM 826  C CA  . GLY A 1 196 ? 88.245  94.547  88.815  1.00 93.07 ? 196 GLY A CA  1 
ATOM 827  C C   . GLY A 1 196 ? 88.611  93.846  90.121  1.00 92.86 ? 196 GLY A C   1 
ATOM 828  O O   . GLY A 1 196 ? 89.253  92.796  90.141  1.00 89.66 ? 196 GLY A O   1 
ATOM 829  N N   . GLU A 1 197 ? 88.188  94.446  91.218  1.00 91.52 ? 197 GLU A N   1 
ATOM 830  C CA  . GLU A 1 197 ? 88.310  93.879  92.560  1.00 89.18 ? 197 GLU A CA  1 
ATOM 831  C C   . GLU A 1 197 ? 86.931  93.456  93.108  1.00 87.27 ? 197 GLU A C   1 
ATOM 832  O O   . GLU A 1 197 ? 85.922  94.097  92.793  1.00 81.50 ? 197 GLU A O   1 
ATOM 833  C CB  . GLU A 1 197 ? 89.007  94.873  93.505  1.00 86.92 ? 197 GLU A CB  1 
ATOM 834  C CG  . GLU A 1 197 ? 90.470  95.181  93.137  1.00 83.01 ? 197 GLU A CG  1 
ATOM 835  C CD  . GLU A 1 197 ? 91.414  93.965  93.177  1.00 80.42 ? 197 GLU A CD  1 
ATOM 836  O OE1 . GLU A 1 197 ? 92.494  94.049  92.543  1.00 70.75 ? 197 GLU A OE1 1 
ATOM 837  O OE2 . GLU A 1 197 ? 91.079  92.953  93.834  1.00 72.39 ? 197 GLU A OE2 1 
ATOM 838  N N   . PRO A 1 198 ? 86.848  92.395  93.940  1.00 84.87 ? 198 PRO A N   1 
ATOM 839  C CA  . PRO A 1 198 ? 87.966  91.572  94.369  1.00 83.98 ? 198 PRO A CA  1 
ATOM 840  C C   . PRO A 1 198 ? 88.442  90.613  93.270  1.00 85.44 ? 198 PRO A C   1 
ATOM 841  O O   . PRO A 1 198 ? 87.635  90.012  92.561  1.00 82.02 ? 198 PRO A O   1 
ATOM 842  C CB  . PRO A 1 198 ? 87.454  90.811  95.598  1.00 79.86 ? 198 PRO A CB  1 
ATOM 843  C CG  . PRO A 1 198 ? 85.962  90.645  95.304  1.00 77.98 ? 198 PRO A CG  1 
ATOM 844  C CD  . PRO A 1 198 ? 85.614  91.931  94.550  1.00 80.76 ? 198 PRO A CD  1 
ATOM 845  N N   . ALA A 1 199 ? 89.757  90.429  93.159  1.00 86.55 ? 199 ALA A N   1 
ATOM 846  C CA  . ALA A 1 199 ? 90.370  89.389  92.348  1.00 87.68 ? 199 ALA A CA  1 
ATOM 847  C C   . ALA A 1 199 ? 91.018  88.330  93.255  1.00 87.68 ? 199 ALA A C   1 
ATOM 848  O O   . ALA A 1 199 ? 91.566  88.672  94.306  1.00 84.16 ? 199 ALA A O   1 
ATOM 849  C CB  . ALA A 1 199 ? 91.377  90.025  91.379  1.00 85.96 ? 199 ALA A CB  1 
ATOM 850  N N   . PRO A 1 200 ? 91.013  87.037  92.876  1.00 86.24 ? 200 PRO A N   1 
ATOM 851  C CA  . PRO A 1 200 ? 91.698  86.002  93.632  1.00 84.76 ? 200 PRO A CA  1 
ATOM 852  C C   . PRO A 1 200 ? 93.209  86.254  93.701  1.00 85.15 ? 200 PRO A C   1 
ATOM 853  O O   . PRO A 1 200 ? 93.838  86.583  92.697  1.00 82.41 ? 200 PRO A O   1 
ATOM 854  C CB  . PRO A 1 200 ? 91.385  84.684  92.924  1.00 82.06 ? 200 PRO A CB  1 
ATOM 855  C CG  . PRO A 1 200 ? 90.132  84.993  92.103  1.00 79.16 ? 200 PRO A CG  1 
ATOM 856  C CD  . PRO A 1 200 ? 90.297  86.470  91.759  1.00 82.32 ? 200 PRO A CD  1 
ATOM 857  N N   . ASN A 1 201 ? 93.809  86.020  94.864  1.00 83.21 ? 201 ASN A N   1 
ATOM 858  C CA  . ASN A 1 201 ? 95.220  86.331  95.124  1.00 82.09 ? 201 ASN A CA  1 
ATOM 859  C C   . ASN A 1 201 ? 96.232  85.610  94.204  1.00 83.19 ? 201 ASN A C   1 
ATOM 860  O O   . ASN A 1 201 ? 97.387  86.019  94.114  1.00 78.29 ? 201 ASN A O   1 
ATOM 861  C CB  . ASN A 1 201 ? 95.538  85.973  96.587  1.00 77.00 ? 201 ASN A CB  1 
ATOM 862  C CG  . ASN A 1 201 ? 94.853  86.879  97.599  1.00 68.76 ? 201 ASN A CG  1 
ATOM 863  O OD1 . ASN A 1 201 ? 94.495  88.002  97.338  1.00 59.55 ? 201 ASN A OD1 1 
ATOM 864  N ND2 . ASN A 1 201 ? 94.678  86.406  98.820  1.00 60.39 ? 201 ASN A ND2 1 
ATOM 865  N N   . TYR A 1 202 ? 95.829  84.513  93.571  1.00 82.94 ? 202 TYR A N   1 
ATOM 866  C CA  . TYR A 1 202 ? 96.671  83.750  92.646  1.00 82.01 ? 202 TYR A CA  1 
ATOM 867  C C   . TYR A 1 202 ? 96.446  84.118  91.171  1.00 82.65 ? 202 TYR A C   1 
ATOM 868  O O   . TYR A 1 202 ? 97.225  83.694  90.324  1.00 78.99 ? 202 TYR A O   1 
ATOM 869  C CB  . TYR A 1 202 ? 96.438  82.248  92.872  1.00 79.54 ? 202 TYR A CB  1 
ATOM 870  C CG  . TYR A 1 202 ? 95.042  81.806  92.516  1.00 78.55 ? 202 TYR A CG  1 
ATOM 871  C CD1 . TYR A 1 202 ? 94.056  81.693  93.514  1.00 72.25 ? 202 TYR A CD1 1 
ATOM 872  C CD2 . TYR A 1 202 ? 94.692  81.557  91.172  1.00 74.74 ? 202 TYR A CD2 1 
ATOM 873  C CE1 . TYR A 1 202 ? 92.737  81.366  93.183  1.00 69.61 ? 202 TYR A CE1 1 
ATOM 874  C CE2 . TYR A 1 202 ? 93.381  81.237  90.818  1.00 70.40 ? 202 TYR A CE2 1 
ATOM 875  C CZ  . TYR A 1 202 ? 92.400  81.156  91.830  1.00 72.74 ? 202 TYR A CZ  1 
ATOM 876  O OH  . TYR A 1 202 ? 91.111  80.884  91.487  1.00 69.98 ? 202 TYR A OH  1 
ATOM 877  N N   . LEU A 1 203 ? 95.394  84.864  90.877  1.00 83.12 ? 203 LEU A N   1 
ATOM 878  C CA  . LEU A 1 203 ? 95.112  85.414  89.553  1.00 81.87 ? 203 LEU A CA  1 
ATOM 879  C C   . LEU A 1 203 ? 95.943  86.682  89.370  1.00 82.18 ? 203 LEU A C   1 
ATOM 880  O O   . LEU A 1 203 ? 95.509  87.791  89.662  1.00 78.39 ? 203 LEU A O   1 
ATOM 881  C CB  . LEU A 1 203 ? 93.590  85.620  89.401  1.00 78.90 ? 203 LEU A CB  1 
ATOM 882  C CG  . LEU A 1 203 ? 92.945  84.653  88.396  1.00 75.42 ? 203 LEU A CG  1 
ATOM 883  C CD1 . LEU A 1 203 ? 91.455  84.471  88.709  1.00 71.03 ? 203 LEU A CD1 1 
ATOM 884  C CD2 . LEU A 1 203 ? 93.055  85.176  86.964  1.00 71.10 ? 203 LEU A CD2 1 
ATOM 885  N N   . LEU A 1 204 ? 97.175  86.477  88.929  1.00 80.70 ? 204 LEU A N   1 
ATOM 886  C CA  . LEU A 1 204 ? 98.153  87.535  88.764  1.00 78.53 ? 204 LEU A CA  1 
ATOM 887  C C   . LEU A 1 204 ? 97.792  88.427  87.572  1.00 80.59 ? 204 LEU A C   1 
ATOM 888  O O   . LEU A 1 204 ? 97.329  87.944  86.541  1.00 73.27 ? 204 LEU A O   1 
ATOM 889  C CB  . LEU A 1 204 ? 99.552  86.913  88.617  1.00 71.08 ? 204 LEU A CB  1 
ATOM 890  C CG  . LEU A 1 204 ? 100.055 86.196  89.892  1.00 64.71 ? 204 LEU A CG  1 
ATOM 891  C CD1 . LEU A 1 204 ? 101.201 85.248  89.558  1.00 58.76 ? 204 LEU A CD1 1 
ATOM 892  C CD2 . LEU A 1 204 ? 100.549 87.202  90.941  1.00 58.47 ? 204 LEU A CD2 1 
ATOM 893  N N   . ASP A 1 205 ? 98.031  89.719  87.721  1.00 85.85 ? 205 ASP A N   1 
ATOM 894  C CA  . ASP A 1 205 ? 98.033  90.721  86.644  1.00 87.21 ? 205 ASP A CA  1 
ATOM 895  C C   . ASP A 1 205 ? 96.721  90.886  85.849  1.00 89.19 ? 205 ASP A C   1 
ATOM 896  O O   . ASP A 1 205 ? 96.699  91.524  84.801  1.00 85.74 ? 205 ASP A O   1 
ATOM 897  C CB  . ASP A 1 205 ? 99.272  90.515  85.766  1.00 83.06 ? 205 ASP A CB  1 
ATOM 898  C CG  . ASP A 1 205 ? 100.555 90.594  86.606  1.00 80.49 ? 205 ASP A CG  1 
ATOM 899  O OD1 . ASP A 1 205 ? 100.756 91.659  87.243  1.00 73.40 ? 205 ASP A OD1 1 
ATOM 900  O OD2 . ASP A 1 205 ? 101.294 89.591  86.657  1.00 74.62 ? 205 ASP A OD2 1 
ATOM 901  N N   . VAL A 1 206 ? 95.591  90.401  86.373  1.00 89.72 ? 206 VAL A N   1 
ATOM 902  C CA  . VAL A 1 206 ? 94.275  90.594  85.741  1.00 89.60 ? 206 VAL A CA  1 
ATOM 903  C C   . VAL A 1 206 ? 93.826  92.053  85.672  1.00 91.13 ? 206 VAL A C   1 
ATOM 904  O O   . VAL A 1 206 ? 92.953  92.390  84.870  1.00 89.05 ? 206 VAL A O   1 
ATOM 905  C CB  . VAL A 1 206 ? 93.184  89.751  86.433  1.00 87.26 ? 206 VAL A CB  1 
ATOM 906  C CG1 . VAL A 1 206 ? 93.464  88.262  86.253  1.00 81.35 ? 206 VAL A CG1 1 
ATOM 907  C CG2 . VAL A 1 206 ? 93.025  90.065  87.932  1.00 81.20 ? 206 VAL A CG2 1 
ATOM 908  N N   . ASN A 1 207 ? 94.440  92.925  86.482  1.00 93.13 ? 207 ASN A N   1 
ATOM 909  C CA  . ASN A 1 207 ? 94.260  94.375  86.465  1.00 93.43 ? 207 ASN A CA  1 
ATOM 910  C C   . ASN A 1 207 ? 95.542  95.115  86.028  1.00 93.74 ? 207 ASN A C   1 
ATOM 911  O O   . ASN A 1 207 ? 95.699  96.298  86.306  1.00 91.75 ? 207 ASN A O   1 
ATOM 912  C CB  . ASN A 1 207 ? 93.755  94.839  87.842  1.00 92.45 ? 207 ASN A CB  1 
ATOM 913  C CG  . ASN A 1 207 ? 92.378  94.288  88.176  1.00 93.00 ? 207 ASN A CG  1 
ATOM 914  O OD1 . ASN A 1 207 ? 91.474  94.222  87.362  1.00 87.54 ? 207 ASN A OD1 1 
ATOM 915  N ND2 . ASN A 1 207 ? 92.167  93.901  89.421  1.00 86.02 ? 207 ASN A ND2 1 
ATOM 916  N N   . TRP A 1 208 ? 96.440  94.432  85.307  1.00 93.74 ? 208 TRP A N   1 
ATOM 917  C CA  . TRP A 1 208 ? 97.735  94.999  84.889  1.00 93.73 ? 208 TRP A CA  1 
ATOM 918  C C   . TRP A 1 208 ? 97.594  96.332  84.143  1.00 94.03 ? 208 TRP A C   1 
ATOM 919  O O   . TRP A 1 208 ? 98.338  97.269  84.409  1.00 92.93 ? 208 TRP A O   1 
ATOM 920  C CB  . TRP A 1 208 ? 98.478  93.972  84.030  1.00 93.23 ? 208 TRP A CB  1 
ATOM 921  C CG  . TRP A 1 208 ? 99.832  94.422  83.572  1.00 92.74 ? 208 TRP A CG  1 
ATOM 922  C CD1 . TRP A 1 208 ? 100.993 94.275  84.263  1.00 89.51 ? 208 TRP A CD1 1 
ATOM 923  C CD2 . TRP A 1 208 ? 100.184 95.111  82.334  1.00 92.13 ? 208 TRP A CD2 1 
ATOM 924  N NE1 . TRP A 1 208 ? 102.037 94.817  83.534  1.00 88.34 ? 208 TRP A NE1 1 
ATOM 925  C CE2 . TRP A 1 208 ? 101.585 95.337  82.342  1.00 90.89 ? 208 TRP A CE2 1 
ATOM 926  C CE3 . TRP A 1 208 ? 99.452  95.555  81.213  1.00 89.21 ? 208 TRP A CE3 1 
ATOM 927  C CZ2 . TRP A 1 208 ? 102.251 95.991  81.273  1.00 89.45 ? 208 TRP A CZ2 1 
ATOM 928  C CZ3 . TRP A 1 208 ? 100.113 96.204  80.146  1.00 87.20 ? 208 TRP A CZ3 1 
ATOM 929  C CH2 . TRP A 1 208 ? 101.495 96.417  80.184  1.00 87.41 ? 208 TRP A CH2 1 
ATOM 930  N N   . LEU A 1 209 ? 96.600  96.440  83.254  1.00 94.57 ? 209 LEU A N   1 
ATOM 931  C CA  . LEU A 1 209 ? 96.345  97.658  82.478  1.00 94.97 ? 209 LEU A CA  1 
ATOM 932  C C   . LEU A 1 209 ? 95.994  98.879  83.346  1.00 94.98 ? 209 LEU A C   1 
ATOM 933  O O   . LEU A 1 209 ? 96.237  100.006 82.929  1.00 93.48 ? 209 LEU A O   1 
ATOM 934  C CB  . LEU A 1 209 ? 95.209  97.389  81.485  1.00 94.79 ? 209 LEU A CB  1 
ATOM 935  C CG  . LEU A 1 209 ? 95.567  96.439  80.337  1.00 94.79 ? 209 LEU A CG  1 
ATOM 936  C CD1 . LEU A 1 209 ? 94.295  96.072  79.576  1.00 92.67 ? 209 LEU A CD1 1 
ATOM 937  C CD2 . LEU A 1 209 ? 96.534  97.084  79.346  1.00 92.30 ? 209 LEU A CD2 1 
ATOM 938  N N   . GLU A 1 210 ? 95.426  98.678  84.537  1.00 94.66 ? 210 GLU A N   1 
ATOM 939  C CA  . GLU A 1 210 ? 95.124  99.772  85.467  1.00 94.12 ? 210 GLU A CA  1 
ATOM 940  C C   . GLU A 1 210 ? 96.392  100.309 86.139  1.00 93.57 ? 210 GLU A C   1 
ATOM 941  O O   . GLU A 1 210 ? 96.490  101.504 86.408  1.00 91.09 ? 210 GLU A O   1 
ATOM 942  C CB  . GLU A 1 210 ? 94.126  99.308  86.536  1.00 93.46 ? 210 GLU A CB  1 
ATOM 943  C CG  . GLU A 1 210 ? 92.742  98.940  85.970  1.00 92.79 ? 210 GLU A CG  1 
ATOM 944  C CD  . GLU A 1 210 ? 91.728  98.531  87.050  1.00 93.30 ? 210 GLU A CD  1 
ATOM 945  O OE1 . GLU A 1 210 ? 90.834  97.713  86.736  1.00 87.06 ? 210 GLU A OE1 1 
ATOM 946  O OE2 . GLU A 1 210 ? 91.808  99.038  88.189  1.00 88.96 ? 210 GLU A OE2 1 
ATOM 947  N N   . ASN A 1 211 ? 97.365  99.428  86.378  1.00 93.24 ? 211 ASN A N   1 
ATOM 948  C CA  . ASN A 1 211 ? 98.548  99.689  87.211  1.00 92.15 ? 211 ASN A CA  1 
ATOM 949  C C   . ASN A 1 211 ? 99.819  99.961  86.399  1.00 92.22 ? 211 ASN A C   1 
ATOM 950  O O   . ASN A 1 211 ? 100.745 100.607 86.905  1.00 88.77 ? 211 ASN A O   1 
ATOM 951  C CB  . ASN A 1 211 ? 98.735  98.473  88.128  1.00 89.58 ? 211 ASN A CB  1 
ATOM 952  C CG  . ASN A 1 211 ? 97.538  98.237  89.036  1.00 85.93 ? 211 ASN A CG  1 
ATOM 953  O OD1 . ASN A 1 211 ? 97.051  99.120  89.709  1.00 75.95 ? 211 ASN A OD1 1 
ATOM 954  N ND2 . ASN A 1 211 ? 97.038  97.026  89.086  1.00 75.11 ? 211 ASN A ND2 1 
ATOM 955  N N   . ALA A 1 212 ? 99.889  99.494  85.134  1.00 91.92 ? 212 ALA A N   1 
ATOM 956  C CA  . ALA A 1 212 ? 101.071 99.585  84.298  1.00 91.84 ? 212 ALA A CA  1 
ATOM 957  C C   . ALA A 1 212 ? 101.562 101.037 84.146  1.00 91.60 ? 212 ALA A C   1 
ATOM 958  O O   . ALA A 1 212 ? 100.838 101.903 83.673  1.00 88.95 ? 212 ALA A O   1 
ATOM 959  C CB  . ALA A 1 212 ? 100.772 98.944  82.940  1.00 91.02 ? 212 ALA A CB  1 
ATOM 960  N N   . GLY A 1 213 ? 102.813 101.280 84.554  1.00 89.59 ? 213 GLY A N   1 
ATOM 961  C CA  . GLY A 1 213 ? 103.437 102.610 84.514  1.00 88.74 ? 213 GLY A CA  1 
ATOM 962  C C   . GLY A 1 213 ? 102.864 103.631 85.503  1.00 89.51 ? 213 GLY A C   1 
ATOM 963  O O   . GLY A 1 213 ? 103.225 104.795 85.430  1.00 84.80 ? 213 GLY A O   1 
ATOM 964  N N   . ARG A 1 214 ? 101.975 103.221 86.416  1.00 89.50 ? 214 ARG A N   1 
ATOM 965  C CA  . ARG A 1 214 ? 101.370 104.112 87.413  1.00 90.04 ? 214 ARG A CA  1 
ATOM 966  C C   . ARG A 1 214 ? 101.668 103.667 88.843  1.00 89.71 ? 214 ARG A C   1 
ATOM 967  O O   . ARG A 1 214 ? 101.981 102.505 89.106  1.00 84.47 ? 214 ARG A O   1 
ATOM 968  C CB  . ARG A 1 214 ? 99.870  104.253 87.170  1.00 87.64 ? 214 ARG A CB  1 
ATOM 969  C CG  . ARG A 1 214 ? 99.560  104.970 85.846  1.00 85.39 ? 214 ARG A CG  1 
ATOM 970  C CD  . ARG A 1 214 ? 98.104  105.430 85.847  1.00 83.27 ? 214 ARG A CD  1 
ATOM 971  N NE  . ARG A 1 214 ? 97.751  106.265 84.691  1.00 82.04 ? 214 ARG A NE  1 
ATOM 972  C CZ  . ARG A 1 214 ? 96.773  107.161 84.663  1.00 82.21 ? 214 ARG A CZ  1 
ATOM 973  N NH1 . ARG A 1 214 ? 96.028  107.392 85.696  1.00 74.01 ? 214 ARG A NH1 1 
ATOM 974  N NH2 . ARG A 1 214 ? 96.532  107.836 83.587  1.00 76.19 ? 214 ARG A NH2 1 
ATOM 975  N N   . SER A 1 215 ? 101.552 104.614 89.768  1.00 87.99 ? 215 SER A N   1 
ATOM 976  C CA  . SER A 1 215 ? 101.604 104.319 91.198  1.00 87.67 ? 215 SER A CA  1 
ATOM 977  C C   . SER A 1 215 ? 100.272 103.724 91.675  1.00 87.60 ? 215 SER A C   1 
ATOM 978  O O   . SER A 1 215 ? 99.217  103.959 91.079  1.00 82.90 ? 215 SER A O   1 
ATOM 979  C CB  . SER A 1 215 ? 101.983 105.567 91.996  1.00 84.34 ? 215 SER A CB  1 
ATOM 980  O OG  . SER A 1 215 ? 101.089 106.633 91.752  1.00 77.10 ? 215 SER A OG  1 
ATOM 981  N N   . SER A 1 216 ? 100.315 102.967 92.764  1.00 85.28 ? 216 SER A N   1 
ATOM 982  C CA  . SER A 1 216 ? 99.144  102.265 93.313  1.00 84.31 ? 216 SER A CA  1 
ATOM 983  C C   . SER A 1 216 ? 97.990  103.181 93.743  1.00 85.38 ? 216 SER A C   1 
ATOM 984  O O   . SER A 1 216 ? 96.845  102.745 93.815  1.00 79.74 ? 216 SER A O   1 
ATOM 985  C CB  . SER A 1 216 ? 99.581  101.426 94.515  1.00 79.80 ? 216 SER A CB  1 
ATOM 986  O OG  . SER A 1 216 ? 100.272 102.218 95.468  1.00 69.87 ? 216 SER A OG  1 
ATOM 987  N N   . ASP A 1 217 ? 98.288  104.444 94.005  1.00 84.24 ? 217 ASP A N   1 
ATOM 988  C CA  . ASP A 1 217 ? 97.345  105.496 94.390  1.00 84.32 ? 217 ASP A CA  1 
ATOM 989  C C   . ASP A 1 217 ? 96.838  106.332 93.197  1.00 86.01 ? 217 ASP A C   1 
ATOM 990  O O   . ASP A 1 217 ? 95.944  107.158 93.363  1.00 79.92 ? 217 ASP A O   1 
ATOM 991  C CB  . ASP A 1 217 ? 98.008  106.375 95.466  1.00 79.91 ? 217 ASP A CB  1 
ATOM 992  C CG  . ASP A 1 217 ? 99.352  107.015 95.050  1.00 70.00 ? 217 ASP A CG  1 
ATOM 993  O OD1 . ASP A 1 217 ? 100.103 106.405 94.264  1.00 60.20 ? 217 ASP A OD1 1 
ATOM 994  O OD2 . ASP A 1 217 ? 99.655  108.110 95.571  1.00 61.69 ? 217 ASP A OD2 1 
ATOM 995  N N   . ASN A 1 218 ? 97.365  106.103 91.993  1.00 88.33 ? 218 ASN A N   1 
ATOM 996  C CA  . ASN A 1 218 ? 96.976  106.814 90.777  1.00 89.41 ? 218 ASN A CA  1 
ATOM 997  C C   . ASN A 1 218 ? 96.801  105.853 89.585  1.00 90.84 ? 218 ASN A C   1 
ATOM 998  O O   . ASN A 1 218 ? 97.380  106.031 88.514  1.00 86.74 ? 218 ASN A O   1 
ATOM 999  C CB  . ASN A 1 218 ? 97.999  107.929 90.520  1.00 85.22 ? 218 ASN A CB  1 
ATOM 1000 C CG  . ASN A 1 218 ? 97.584  108.857 89.390  1.00 78.75 ? 218 ASN A CG  1 
ATOM 1001 O OD1 . ASN A 1 218 ? 96.415  109.101 89.132  1.00 69.55 ? 218 ASN A OD1 1 
ATOM 1002 N ND2 . ASN A 1 218 ? 98.540  109.414 88.684  1.00 69.20 ? 218 ASN A ND2 1 
ATOM 1003 N N   . THR A 1 219 ? 95.991  104.821 89.765  1.00 91.12 ? 219 THR A N   1 
ATOM 1004 C CA  . THR A 1 219 ? 95.681  103.829 88.736  1.00 91.45 ? 219 THR A CA  1 
ATOM 1005 C C   . THR A 1 219 ? 94.816  104.414 87.612  1.00 92.35 ? 219 THR A C   1 
ATOM 1006 O O   . THR A 1 219 ? 94.141  105.431 87.778  1.00 89.18 ? 219 THR A O   1 
ATOM 1007 C CB  . THR A 1 219 ? 95.012  102.598 89.351  1.00 88.25 ? 219 THR A CB  1 
ATOM 1008 O OG1 . THR A 1 219 ? 93.838  102.964 90.039  1.00 78.29 ? 219 THR A OG1 1 
ATOM 1009 C CG2 . THR A 1 219 ? 95.928  101.891 90.350  1.00 77.10 ? 219 THR A CG2 1 
ATOM 1010 N N   . ARG A 1 220 ? 94.832  103.785 86.435  1.00 92.64 ? 220 ARG A N   1 
ATOM 1011 C CA  . ARG A 1 220 ? 93.930  104.153 85.332  1.00 93.12 ? 220 ARG A CA  1 
ATOM 1012 C C   . ARG A 1 220 ? 92.487  103.785 85.671  1.00 93.28 ? 220 ARG A C   1 
ATOM 1013 O O   . ARG A 1 220 ? 92.234  102.748 86.279  1.00 91.50 ? 220 ARG A O   1 
ATOM 1014 C CB  . ARG A 1 220 ? 94.347  103.473 84.017  1.00 91.99 ? 220 ARG A CB  1 
ATOM 1015 C CG  . ARG A 1 220 ? 95.675  104.022 83.489  1.00 89.35 ? 220 ARG A CG  1 
ATOM 1016 C CD  . ARG A 1 220 ? 96.058  103.411 82.138  1.00 89.53 ? 220 ARG A CD  1 
ATOM 1017 N NE  . ARG A 1 220 ? 97.388  103.882 81.761  1.00 89.05 ? 220 ARG A NE  1 
ATOM 1018 C CZ  . ARG A 1 220 ? 98.546  103.335 82.119  1.00 91.27 ? 220 ARG A CZ  1 
ATOM 1019 N NH1 . ARG A 1 220 ? 98.628  102.198 82.762  1.00 80.75 ? 220 ARG A NH1 1 
ATOM 1020 N NH2 . ARG A 1 220 ? 99.646  103.959 81.843  1.00 85.06 ? 220 ARG A NH2 1 
ATOM 1021 N N   . ILE A 1 221 ? 91.554  104.614 85.237  1.00 93.50 ? 221 ILE A N   1 
ATOM 1022 C CA  . ILE A 1 221 ? 90.130  104.314 85.366  1.00 92.81 ? 221 ILE A CA  1 
ATOM 1023 C C   . ILE A 1 221 ? 89.735  103.395 84.206  1.00 93.78 ? 221 ILE A C   1 
ATOM 1024 O O   . ILE A 1 221 ? 89.758  103.834 83.054  1.00 92.06 ? 221 ILE A O   1 
ATOM 1025 C CB  . ILE A 1 221 ? 89.290  105.606 85.413  1.00 90.18 ? 221 ILE A CB  1 
ATOM 1026 C CG1 . ILE A 1 221 ? 89.736  106.501 86.597  1.00 84.59 ? 221 ILE A CG1 1 
ATOM 1027 C CG2 . ILE A 1 221 ? 87.794  105.245 85.538  1.00 82.23 ? 221 ILE A CG2 1 
ATOM 1028 C CD1 . ILE A 1 221 ? 89.018  107.865 86.665  1.00 73.04 ? 221 ILE A CD1 1 
ATOM 1029 N N   . PRO A 1 222 ? 89.355  102.137 84.463  1.00 94.58 ? 222 PRO A N   1 
ATOM 1030 C CA  . PRO A 1 222 ? 88.913  101.234 83.411  1.00 95.01 ? 222 PRO A CA  1 
ATOM 1031 C C   . PRO A 1 222 ? 87.544  101.664 82.878  1.00 95.10 ? 222 PRO A C   1 
ATOM 1032 O O   . PRO A 1 222 ? 86.668  102.097 83.624  1.00 93.51 ? 222 PRO A O   1 
ATOM 1033 C CB  . PRO A 1 222 ? 88.879  99.847  84.056  1.00 93.57 ? 222 PRO A CB  1 
ATOM 1034 C CG  . PRO A 1 222 ? 88.573  100.164 85.514  1.00 90.98 ? 222 PRO A CG  1 
ATOM 1035 C CD  . PRO A 1 222 ? 89.305  101.480 85.760  1.00 93.53 ? 222 PRO A CD  1 
ATOM 1036 N N   . HIS A 1 223 ? 87.353  101.494 81.568  1.00 94.73 ? 223 HIS A N   1 
ATOM 1037 C CA  . HIS A 1 223 ? 86.061  101.742 80.934  1.00 95.16 ? 223 HIS A CA  1 
ATOM 1038 C C   . HIS A 1 223 ? 85.057  100.633 81.258  1.00 95.65 ? 223 HIS A C   1 
ATOM 1039 O O   . HIS A 1 223 ? 83.854  100.882 81.400  1.00 93.83 ? 223 HIS A O   1 
ATOM 1040 C CB  . HIS A 1 223 ? 86.279  101.894 79.423  1.00 93.96 ? 223 HIS A CB  1 
ATOM 1041 C CG  . HIS A 1 223 ? 85.091  102.484 78.727  1.00 93.35 ? 223 HIS A CG  1 
ATOM 1042 N ND1 . HIS A 1 223 ? 84.401  103.621 79.123  1.00 85.13 ? 223 HIS A ND1 1 
ATOM 1043 C CD2 . HIS A 1 223 ? 84.504  102.043 77.562  1.00 84.89 ? 223 HIS A CD2 1 
ATOM 1044 C CE1 . HIS A 1 223 ? 83.429  103.848 78.222  1.00 87.31 ? 223 HIS A CE1 1 
ATOM 1045 N NE2 . HIS A 1 223 ? 83.467  102.918 77.263  1.00 88.77 ? 223 HIS A NE2 1 
ATOM 1046 N N   . LEU A 1 224 ? 85.560  99.415  81.405  1.00 95.09 ? 224 LEU A N   1 
ATOM 1047 C CA  . LEU A 1 224 ? 84.781  98.249  81.800  1.00 95.20 ? 224 LEU A CA  1 
ATOM 1048 C C   . LEU A 1 224 ? 85.609  97.357  82.722  1.00 95.63 ? 224 LEU A C   1 
ATOM 1049 O O   . LEU A 1 224 ? 86.776  97.092  82.456  1.00 95.03 ? 224 LEU A O   1 
ATOM 1050 C CB  . LEU A 1 224 ? 84.349  97.516  80.515  1.00 94.73 ? 224 LEU A CB  1 
ATOM 1051 C CG  . LEU A 1 224 ? 83.561  96.208  80.732  1.00 93.55 ? 224 LEU A CG  1 
ATOM 1052 C CD1 . LEU A 1 224 ? 82.255  96.425  81.495  1.00 89.43 ? 224 LEU A CD1 1 
ATOM 1053 C CD2 . LEU A 1 224 ? 83.215  95.628  79.367  1.00 89.57 ? 224 LEU A CD2 1 
ATOM 1054 N N   . GLN A 1 225 ? 84.980  96.853  83.767  1.00 95.02 ? 225 GLN A N   1 
ATOM 1055 C CA  . GLN A 1 225 ? 85.513  95.763  84.581  1.00 94.99 ? 225 GLN A CA  1 
ATOM 1056 C C   . GLN A 1 225 ? 84.528  94.587  84.558  1.00 94.36 ? 225 GLN A C   1 
ATOM 1057 O O   . GLN A 1 225 ? 83.318  94.795  84.685  1.00 93.66 ? 225 GLN A O   1 
ATOM 1058 C CB  . GLN A 1 225 ? 85.768  96.222  86.017  1.00 94.04 ? 225 GLN A CB  1 
ATOM 1059 C CG  . GLN A 1 225 ? 86.944  97.203  86.142  1.00 92.81 ? 225 GLN A CG  1 
ATOM 1060 C CD  . GLN A 1 225 ? 87.082  97.755  87.556  1.00 93.98 ? 225 GLN A CD  1 
ATOM 1061 O OE1 . GLN A 1 225 ? 86.109  98.005  88.270  1.00 86.57 ? 225 GLN A OE1 1 
ATOM 1062 N NE2 . GLN A 1 225 ? 88.285  97.986  88.023  1.00 85.66 ? 225 GLN A NE2 1 
ATOM 1063 N N   . ILE A 1 226 ? 85.034  93.378  84.415  1.00 95.34 ? 226 ILE A N   1 
ATOM 1064 C CA  . ILE A 1 226 ? 84.239  92.150  84.516  1.00 95.45 ? 226 ILE A CA  1 
ATOM 1065 C C   . ILE A 1 226 ? 85.092  91.069  85.185  1.00 94.67 ? 226 ILE A C   1 
ATOM 1066 O O   . ILE A 1 226 ? 86.131  90.689  84.643  1.00 93.94 ? 226 ILE A O   1 
ATOM 1067 C CB  . ILE A 1 226 ? 83.729  91.647  83.135  1.00 95.28 ? 226 ILE A CB  1 
ATOM 1068 C CG1 . ILE A 1 226 ? 83.131  92.751  82.251  1.00 87.93 ? 226 ILE A CG1 1 
ATOM 1069 C CG2 . ILE A 1 226 ? 82.688  90.535  83.374  1.00 86.74 ? 226 ILE A CG2 1 
ATOM 1070 C CD1 . ILE A 1 226 ? 82.680  92.287  80.863  1.00 87.65 ? 226 ILE A CD1 1 
ATOM 1071 N N   . ASN A 1 227 ? 84.632  90.526  86.283  1.00 95.21 ? 227 ASN A N   1 
ATOM 1072 C CA  . ASN A 1 227 ? 85.305  89.426  86.999  1.00 93.81 ? 227 ASN A CA  1 
ATOM 1073 C C   . ASN A 1 227 ? 85.146  88.064  86.289  1.00 93.88 ? 227 ASN A C   1 
ATOM 1074 O O   . ASN A 1 227 ? 84.832  87.045  86.908  1.00 91.48 ? 227 ASN A O   1 
ATOM 1075 C CB  . ASN A 1 227 ? 84.838  89.420  88.465  1.00 91.78 ? 227 ASN A CB  1 
ATOM 1076 C CG  . ASN A 1 227 ? 83.370  89.076  88.630  1.00 92.19 ? 227 ASN A CG  1 
ATOM 1077 O OD1 . ASN A 1 227 ? 82.549  89.329  87.771  1.00 87.86 ? 227 ASN A OD1 1 
ATOM 1078 N ND2 . ASN A 1 227 ? 83.012  88.515  89.764  1.00 85.46 ? 227 ASN A ND2 1 
ATOM 1079 N N   . SER A 1 228 ? 85.310  88.053  84.973  1.00 94.56 ? 228 SER A N   1 
ATOM 1080 C CA  . SER A 1 228 ? 85.222  86.865  84.132  1.00 94.95 ? 228 SER A CA  1 
ATOM 1081 C C   . SER A 1 228 ? 86.107  87.027  82.905  1.00 95.20 ? 228 SER A C   1 
ATOM 1082 O O   . SER A 1 228 ? 85.806  87.826  82.012  1.00 94.64 ? 228 SER A O   1 
ATOM 1083 C CB  . SER A 1 228 ? 83.766  86.642  83.708  1.00 94.08 ? 228 SER A CB  1 
ATOM 1084 O OG  . SER A 1 228 ? 83.682  85.669  82.680  1.00 91.89 ? 228 SER A OG  1 
ATOM 1085 N N   . GLN A 1 229 ? 87.167  86.222  82.808  1.00 95.45 ? 229 GLN A N   1 
ATOM 1086 C CA  . GLN A 1 229 ? 88.129  86.283  81.704  1.00 95.28 ? 229 GLN A CA  1 
ATOM 1087 C C   . GLN A 1 229 ? 87.479  86.070  80.328  1.00 95.78 ? 229 GLN A C   1 
ATOM 1088 O O   . GLN A 1 229 ? 87.803  86.765  79.364  1.00 94.88 ? 229 GLN A O   1 
ATOM 1089 C CB  . GLN A 1 229 ? 89.229  85.234  81.938  1.00 93.80 ? 229 GLN A CB  1 
ATOM 1090 C CG  . GLN A 1 229 ? 90.150  85.533  83.138  1.00 89.41 ? 229 GLN A CG  1 
ATOM 1091 C CD  . GLN A 1 229 ? 91.125  86.683  82.900  1.00 84.98 ? 229 GLN A CD  1 
ATOM 1092 O OE1 . GLN A 1 229 ? 91.093  87.362  81.900  1.00 73.77 ? 229 GLN A OE1 1 
ATOM 1093 N NE2 . GLN A 1 229 ? 92.015  86.936  83.819  1.00 71.76 ? 229 GLN A NE2 1 
ATOM 1094 N N   . THR A 1 230 ? 86.525  85.158  80.227  1.00 95.13 ? 230 THR A N   1 
ATOM 1095 C CA  . THR A 1 230 ? 85.794  84.906  78.971  1.00 95.18 ? 230 THR A CA  1 
ATOM 1096 C C   . THR A 1 230 ? 84.910  86.095  78.570  1.00 95.74 ? 230 THR A C   1 
ATOM 1097 O O   . THR A 1 230 ? 84.824  86.418  77.390  1.00 94.95 ? 230 THR A O   1 
ATOM 1098 C CB  . THR A 1 230 ? 84.936  83.641  79.067  1.00 94.07 ? 230 THR A CB  1 
ATOM 1099 O OG1 . THR A 1 230 ? 84.120  83.704  80.212  1.00 86.64 ? 230 THR A OG1 1 
ATOM 1100 C CG2 . THR A 1 230 ? 85.799  82.386  79.174  1.00 85.29 ? 230 THR A CG2 1 
ATOM 1101 N N   . SER A 1 231 ? 84.314  86.786  79.533  1.00 94.61 ? 231 SER A N   1 
ATOM 1102 C CA  . SER A 1 231 ? 83.544  88.003  79.279  1.00 95.45 ? 231 SER A CA  1 
ATOM 1103 C C   . SER A 1 231 ? 84.449  89.183  78.912  1.00 96.04 ? 231 SER A C   1 
ATOM 1104 O O   . SER A 1 231 ? 84.079  89.966  78.046  1.00 96.07 ? 231 SER A O   1 
ATOM 1105 C CB  . SER A 1 231 ? 82.681  88.360  80.483  1.00 95.50 ? 231 SER A CB  1 
ATOM 1106 O OG  . SER A 1 231 ? 81.712  87.349  80.697  1.00 91.42 ? 231 SER A OG  1 
ATOM 1107 N N   . ILE A 1 232 ? 85.647  89.288  79.506  1.00 96.30 ? 232 ILE A N   1 
ATOM 1108 C CA  . ILE A 1 232 ? 86.654  90.276  79.089  1.00 96.63 ? 232 ILE A CA  1 
ATOM 1109 C C   . ILE A 1 232 ? 87.059  90.029  77.628  1.00 96.40 ? 232 ILE A C   1 
ATOM 1110 O O   . ILE A 1 232 ? 87.044  90.969  76.836  1.00 95.76 ? 232 ILE A O   1 
ATOM 1111 C CB  . ILE A 1 232 ? 87.885  90.265  80.026  1.00 96.60 ? 232 ILE A CB  1 
ATOM 1112 C CG1 . ILE A 1 232 ? 87.491  90.750  81.441  1.00 95.32 ? 232 ILE A CG1 1 
ATOM 1113 C CG2 . ILE A 1 232 ? 89.003  91.173  79.473  1.00 95.02 ? 232 ILE A CG2 1 
ATOM 1114 C CD1 . ILE A 1 232 ? 88.578  90.487  82.494  1.00 93.26 ? 232 ILE A CD1 1 
ATOM 1115 N N   . LYS A 1 233 ? 87.330  88.778  77.241  1.00 96.80 ? 233 LYS A N   1 
ATOM 1116 C CA  . LYS A 1 233 ? 87.588  88.431  75.835  1.00 96.45 ? 233 LYS A CA  1 
ATOM 1117 C C   . LYS A 1 233 ? 86.431  88.855  74.933  1.00 96.26 ? 233 LYS A C   1 
ATOM 1118 O O   . LYS A 1 233 ? 86.658  89.461  73.892  1.00 95.54 ? 233 LYS A O   1 
ATOM 1119 C CB  . LYS A 1 233 ? 87.866  86.926  75.700  1.00 95.57 ? 233 LYS A CB  1 
ATOM 1120 C CG  . LYS A 1 233 ? 88.120  86.507  74.238  1.00 94.12 ? 233 LYS A CG  1 
ATOM 1121 C CD  . LYS A 1 233 ? 88.336  84.998  74.126  1.00 90.56 ? 233 LYS A CD  1 
ATOM 1122 C CE  . LYS A 1 233 ? 88.538  84.593  72.659  1.00 85.40 ? 233 LYS A CE  1 
ATOM 1123 N NZ  . LYS A 1 233 ? 88.919  83.159  72.528  1.00 79.79 ? 233 LYS A NZ  1 
ATOM 1124 N N   . ARG A 1 234 ? 85.191  88.565  75.327  1.00 95.89 ? 234 ARG A N   1 
ATOM 1125 C CA  . ARG A 1 234 ? 84.000  88.943  74.567  1.00 95.44 ? 234 ARG A CA  1 
ATOM 1126 C C   . ARG A 1 234 ? 83.885  90.466  74.423  1.00 95.45 ? 234 ARG A C   1 
ATOM 1127 O O   . ARG A 1 234 ? 83.688  90.941  73.318  1.00 94.81 ? 234 ARG A O   1 
ATOM 1128 C CB  . ARG A 1 234 ? 82.760  88.318  75.217  1.00 94.67 ? 234 ARG A CB  1 
ATOM 1129 C CG  . ARG A 1 234 ? 81.434  88.660  74.502  1.00 91.33 ? 234 ARG A CG  1 
ATOM 1130 C CD  . ARG A 1 234 ? 81.434  88.216  73.032  1.00 86.94 ? 234 ARG A CD  1 
ATOM 1131 N NE  . ARG A 1 234 ? 80.143  88.501  72.409  1.00 83.19 ? 234 ARG A NE  1 
ATOM 1132 C CZ  . ARG A 1 234 ? 79.837  88.421  71.120  1.00 78.06 ? 234 ARG A CZ  1 
ATOM 1133 N NH1 . ARG A 1 234 ? 80.721  88.026  70.237  1.00 70.91 ? 234 ARG A NH1 1 
ATOM 1134 N NH2 . ARG A 1 234 ? 78.657  88.760  70.730  1.00 73.27 ? 234 ARG A NH2 1 
ATOM 1135 N N   . ALA A 1 235 ? 84.075  91.195  75.508  1.00 96.01 ? 235 ALA A N   1 
ATOM 1136 C CA  . ALA A 1 235 ? 84.057  92.658  75.506  1.00 96.26 ? 235 ALA A CA  1 
ATOM 1137 C C   . ALA A 1 235 ? 85.172  93.250  74.622  1.00 96.23 ? 235 ALA A C   1 
ATOM 1138 O O   . ALA A 1 235 ? 84.931  94.216  73.893  1.00 95.68 ? 235 ALA A O   1 
ATOM 1139 C CB  . ALA A 1 235 ? 84.185  93.126  76.957  1.00 96.37 ? 235 ALA A CB  1 
ATOM 1140 N N   . CYS A 1 236 ? 86.353  92.646  74.630  1.00 96.13 ? 236 CYS A N   1 
ATOM 1141 C CA  . CYS A 1 236 ? 87.467  93.023  73.766  1.00 95.73 ? 236 CYS A CA  1 
ATOM 1142 C C   . CYS A 1 236 ? 87.126  92.779  72.279  1.00 95.17 ? 236 CYS A C   1 
ATOM 1143 O O   . CYS A 1 236 ? 87.254  93.691  71.468  1.00 94.01 ? 236 CYS A O   1 
ATOM 1144 C CB  . CYS A 1 236 ? 88.712  92.247  74.219  1.00 95.67 ? 236 CYS A CB  1 
ATOM 1145 S SG  . CYS A 1 236 ? 90.203  92.874  73.408  1.00 94.75 ? 236 CYS A SG  1 
ATOM 1146 N N   . LEU A 1 237 ? 86.582  91.598  71.939  1.00 94.52 ? 237 LEU A N   1 
ATOM 1147 C CA  . LEU A 1 237 ? 86.129  91.258  70.581  1.00 93.10 ? 237 LEU A CA  1 
ATOM 1148 C C   . LEU A 1 237 ? 85.028  92.203  70.073  1.00 92.21 ? 237 LEU A C   1 
ATOM 1149 O O   . LEU A 1 237 ? 85.008  92.542  68.889  1.00 91.04 ? 237 LEU A O   1 
ATOM 1150 C CB  . LEU A 1 237 ? 85.610  89.808  70.556  1.00 91.88 ? 237 LEU A CB  1 
ATOM 1151 C CG  . LEU A 1 237 ? 86.707  88.737  70.545  1.00 86.87 ? 237 LEU A CG  1 
ATOM 1152 C CD1 . LEU A 1 237 ? 86.090  87.361  70.820  1.00 83.39 ? 237 LEU A CD1 1 
ATOM 1153 C CD2 . LEU A 1 237 ? 87.414  88.663  69.188  1.00 83.76 ? 237 LEU A CD2 1 
ATOM 1154 N N   . LEU A 1 238 ? 84.149  92.655  70.955  1.00 93.44 ? 238 LEU A N   1 
ATOM 1155 C CA  . LEU A 1 238 ? 83.107  93.641  70.639  1.00 92.23 ? 238 LEU A CA  1 
ATOM 1156 C C   . LEU A 1 238 ? 83.655  95.067  70.442  1.00 91.83 ? 238 LEU A C   1 
ATOM 1157 O O   . LEU A 1 238 ? 82.893  95.978  70.128  1.00 90.24 ? 238 LEU A O   1 
ATOM 1158 C CB  . LEU A 1 238 ? 82.043  93.608  71.746  1.00 91.77 ? 238 LEU A CB  1 
ATOM 1159 C CG  . LEU A 1 238 ? 81.184  92.329  71.783  1.00 90.67 ? 238 LEU A CG  1 
ATOM 1160 C CD1 . LEU A 1 238 ? 80.364  92.317  73.078  1.00 87.63 ? 238 LEU A CD1 1 
ATOM 1161 C CD2 . LEU A 1 238 ? 80.228  92.245  70.600  1.00 87.27 ? 238 LEU A CD2 1 
ATOM 1162 N N   . GLY A 1 239 ? 84.954  95.273  70.623  1.00 92.80 ? 239 GLY A N   1 
ATOM 1163 C CA  . GLY A 1 239 ? 85.606  96.566  70.443  1.00 92.40 ? 239 GLY A CA  1 
ATOM 1164 C C   . GLY A 1 239 ? 85.305  97.584  71.546  1.00 93.12 ? 239 GLY A C   1 
ATOM 1165 O O   . GLY A 1 239 ? 85.309  98.783  71.278  1.00 91.79 ? 239 GLY A O   1 
ATOM 1166 N N   . ILE A 1 240 ? 85.029  97.133  72.769  1.00 94.94 ? 240 ILE A N   1 
ATOM 1167 C CA  . ILE A 1 240 ? 84.808  98.034  73.910  1.00 95.12 ? 240 ILE A CA  1 
ATOM 1168 C C   . ILE A 1 240 ? 86.111  98.715  74.348  1.00 95.07 ? 240 ILE A C   1 
ATOM 1169 O O   . ILE A 1 240 ? 86.096  99.871  74.759  1.00 93.86 ? 240 ILE A O   1 
ATOM 1170 C CB  . ILE A 1 240 ? 84.146  97.279  75.098  1.00 95.22 ? 240 ILE A CB  1 
ATOM 1171 C CG1 . ILE A 1 240 ? 82.783  96.704  74.681  1.00 93.68 ? 240 ILE A CG1 1 
ATOM 1172 C CG2 . ILE A 1 240 ? 83.992  98.208  76.324  1.00 93.10 ? 240 ILE A CG2 1 
ATOM 1173 C CD1 . ILE A 1 240 ? 82.058  95.909  75.780  1.00 90.62 ? 240 ILE A CD1 1 
ATOM 1174 N N   . GLY A 1 241 ? 87.225  97.998  74.269  1.00 96.22 ? 241 GLY A N   1 
ATOM 1175 C CA  . GLY A 1 241 ? 88.516  98.479  74.728  1.00 96.32 ? 241 GLY A CA  1 
ATOM 1176 C C   . GLY A 1 241 ? 89.627  97.448  74.609  1.00 96.74 ? 241 GLY A C   1 
ATOM 1177 O O   . GLY A 1 241 ? 89.467  96.379  74.013  1.00 95.77 ? 241 GLY A O   1 
ATOM 1178 N N   . ILE A 1 242 ? 90.759  97.821  75.192  1.00 97.49 ? 242 ILE A N   1 
ATOM 1179 C CA  . ILE A 1 242 ? 91.974  97.015  75.262  1.00 97.68 ? 242 ILE A CA  1 
ATOM 1180 C C   . ILE A 1 242 ? 91.893  96.113  76.499  1.00 97.67 ? 242 ILE A C   1 
ATOM 1181 O O   . ILE A 1 242 ? 91.484  96.558  77.567  1.00 97.04 ? 242 ILE A O   1 
ATOM 1182 C CB  . ILE A 1 242 ? 93.196  97.950  75.304  1.00 97.19 ? 242 ILE A CB  1 
ATOM 1183 C CG1 . ILE A 1 242 ? 93.262  98.815  74.017  1.00 95.28 ? 242 ILE A CG1 1 
ATOM 1184 C CG2 . ILE A 1 242 ? 94.500  97.157  75.477  1.00 95.43 ? 242 ILE A CG2 1 
ATOM 1185 C CD1 . ILE A 1 242 ? 94.265  99.966  74.109  1.00 92.31 ? 242 ILE A CD1 1 
ATOM 1186 N N   . ALA A 1 243 ? 92.306  94.854  76.362  1.00 97.23 ? 243 ALA A N   1 
ATOM 1187 C CA  . ALA A 1 243 ? 92.276  93.884  77.446  1.00 97.19 ? 243 ALA A CA  1 
ATOM 1188 C C   . ALA A 1 243 ? 93.625  93.173  77.611  1.00 96.83 ? 243 ALA A C   1 
ATOM 1189 O O   . ALA A 1 243 ? 94.293  92.861  76.631  1.00 96.01 ? 243 ALA A O   1 
ATOM 1190 C CB  . ALA A 1 243 ? 91.149  92.880  77.185  1.00 96.62 ? 243 ALA A CB  1 
ATOM 1191 N N   . CYS A 1 244 ? 93.990  92.866  78.844  1.00 96.44 ? 244 CYS A N   1 
ATOM 1192 C CA  . CYS A 1 244 ? 95.080  91.953  79.166  1.00 96.01 ? 244 CYS A CA  1 
ATOM 1193 C C   . CYS A 1 244 ? 94.495  90.562  79.441  1.00 95.86 ? 244 CYS A C   1 
ATOM 1194 O O   . CYS A 1 244 ? 93.650  90.412  80.324  1.00 94.72 ? 244 CYS A O   1 
ATOM 1195 C CB  . CYS A 1 244 ? 95.863  92.511  80.358  1.00 95.17 ? 244 CYS A CB  1 
ATOM 1196 S SG  . CYS A 1 244 ? 97.271  91.444  80.726  1.00 91.63 ? 244 CYS A SG  1 
ATOM 1197 N N   . LEU A 1 245 ? 94.913  89.560  78.671  1.00 95.25 ? 245 LEU A N   1 
ATOM 1198 C CA  . LEU A 1 245 ? 94.330  88.216  78.712  1.00 95.12 ? 245 LEU A CA  1 
ATOM 1199 C C   . LEU A 1 245 ? 95.414  87.133  78.665  1.00 94.74 ? 245 LEU A C   1 
ATOM 1200 O O   . LEU A 1 245 ? 96.404  87.288  77.943  1.00 93.78 ? 245 LEU A O   1 
ATOM 1201 C CB  . LEU A 1 245 ? 93.363  88.045  77.527  1.00 94.87 ? 245 LEU A CB  1 
ATOM 1202 C CG  . LEU A 1 245 ? 92.059  88.856  77.625  1.00 94.70 ? 245 LEU A CG  1 
ATOM 1203 C CD1 . LEU A 1 245 ? 91.302  88.776  76.298  1.00 92.64 ? 245 LEU A CD1 1 
ATOM 1204 C CD2 . LEU A 1 245 ? 91.138  88.321  78.726  1.00 92.28 ? 245 LEU A CD2 1 
ATOM 1205 N N   . PRO A 1 246 ? 95.210  86.014  79.363  1.00 94.29 ? 246 PRO A N   1 
ATOM 1206 C CA  . PRO A 1 246 ? 96.068  84.852  79.217  1.00 94.07 ? 246 PRO A CA  1 
ATOM 1207 C C   . PRO A 1 246 ? 95.812  84.133  77.889  1.00 93.79 ? 246 PRO A C   1 
ATOM 1208 O O   . PRO A 1 246 ? 94.688  84.102  77.379  1.00 92.38 ? 246 PRO A O   1 
ATOM 1209 C CB  . PRO A 1 246 ? 95.743  83.972  80.426  1.00 93.10 ? 246 PRO A CB  1 
ATOM 1210 C CG  . PRO A 1 246 ? 94.281  84.297  80.712  1.00 91.58 ? 246 PRO A CG  1 
ATOM 1211 C CD  . PRO A 1 246 ? 94.156  85.769  80.324  1.00 93.74 ? 246 PRO A CD  1 
ATOM 1212 N N   . ASP A 1 247 ? 96.865  83.503  77.373  1.00 92.24 ? 247 ASP A N   1 
ATOM 1213 C CA  . ASP A 1 247 ? 96.837  82.729  76.125  1.00 90.94 ? 247 ASP A CA  1 
ATOM 1214 C C   . ASP A 1 247 ? 95.731  81.650  76.086  1.00 91.47 ? 247 ASP A C   1 
ATOM 1215 O O   . ASP A 1 247 ? 95.056  81.509  75.063  1.00 88.47 ? 247 ASP A O   1 
ATOM 1216 C CB  . ASP A 1 247 ? 98.238  82.150  75.884  1.00 87.32 ? 247 ASP A CB  1 
ATOM 1217 C CG  . ASP A 1 247 ? 98.853  81.354  77.056  1.00 80.96 ? 247 ASP A CG  1 
ATOM 1218 O OD1 . ASP A 1 247 ? 98.149  81.123  78.069  1.00 72.13 ? 247 ASP A OD1 1 
ATOM 1219 O OD2 . ASP A 1 247 ? 100.054 81.004  76.968  1.00 75.91 ? 247 ASP A OD2 1 
ATOM 1220 N N   . TYR A 1 248 ? 95.459  80.952  77.201  1.00 92.27 ? 248 TYR A N   1 
ATOM 1221 C CA  . TYR A 1 248 ? 94.410  79.925  77.259  1.00 92.47 ? 248 TYR A CA  1 
ATOM 1222 C C   . TYR A 1 248 ? 92.973  80.463  77.105  1.00 92.64 ? 248 TYR A C   1 
ATOM 1223 O O   . TYR A 1 248 ? 92.057  79.692  76.806  1.00 91.24 ? 248 TYR A O   1 
ATOM 1224 C CB  . TYR A 1 248 ? 94.523  79.103  78.558  1.00 92.08 ? 248 TYR A CB  1 
ATOM 1225 C CG  . TYR A 1 248 ? 94.253  79.860  79.846  1.00 92.39 ? 248 TYR A CG  1 
ATOM 1226 C CD1 . TYR A 1 248 ? 95.325  80.204  80.692  1.00 89.73 ? 248 TYR A CD1 1 
ATOM 1227 C CD2 . TYR A 1 248 ? 92.940  80.223  80.228  1.00 89.78 ? 248 TYR A CD2 1 
ATOM 1228 C CE1 . TYR A 1 248 ? 95.091  80.918  81.880  1.00 88.51 ? 248 TYR A CE1 1 
ATOM 1229 C CE2 . TYR A 1 248 ? 92.705  80.949  81.403  1.00 87.61 ? 248 TYR A CE2 1 
ATOM 1230 C CZ  . TYR A 1 248 ? 93.787  81.297  82.226  1.00 89.84 ? 248 TYR A CZ  1 
ATOM 1231 O OH  . TYR A 1 248 ? 93.564  82.021  83.371  1.00 87.90 ? 248 TYR A OH  1 
ATOM 1232 N N   . ILE A 1 249 ? 92.769  81.761  77.289  1.00 93.73 ? 249 ILE A N   1 
ATOM 1233 C CA  . ILE A 1 249 ? 91.490  82.434  77.019  1.00 93.94 ? 249 ILE A CA  1 
ATOM 1234 C C   . ILE A 1 249 ? 91.432  82.880  75.556  1.00 93.22 ? 249 ILE A C   1 
ATOM 1235 O O   . ILE A 1 249 ? 90.404  82.714  74.895  1.00 90.98 ? 249 ILE A O   1 
ATOM 1236 C CB  . ILE A 1 249 ? 91.281  83.624  77.975  1.00 93.82 ? 249 ILE A CB  1 
ATOM 1237 C CG1 . ILE A 1 249 ? 91.171  83.177  79.451  1.00 91.18 ? 249 ILE A CG1 1 
ATOM 1238 C CG2 . ILE A 1 249 ? 90.054  84.471  77.582  1.00 92.01 ? 249 ILE A CG2 1 
ATOM 1239 C CD1 . ILE A 1 249 ? 89.916  82.357  79.795  1.00 87.54 ? 249 ILE A CD1 1 
ATOM 1240 N N   . VAL A 1 250 ? 92.531  83.442  75.077  1.00 92.31 ? 250 VAL A N   1 
ATOM 1241 C CA  . VAL A 1 250 ? 92.607  84.004  73.723  1.00 90.98 ? 250 VAL A CA  1 
ATOM 1242 C C   . VAL A 1 250 ? 92.582  82.899  72.666  1.00 87.91 ? 250 VAL A C   1 
ATOM 1243 O O   . VAL A 1 250 ? 91.744  82.928  71.760  1.00 80.39 ? 250 VAL A O   1 
ATOM 1244 C CB  . VAL A 1 250 ? 93.837  84.936  73.610  1.00 89.99 ? 250 VAL A CB  1 
ATOM 1245 C CG1 . VAL A 1 250 ? 93.943  85.526  72.218  1.00 80.47 ? 250 VAL A CG1 1 
ATOM 1246 C CG2 . VAL A 1 250 ? 93.713  86.103  74.602  1.00 81.72 ? 250 VAL A CG2 1 
ATOM 1247 N N   . GLY A 1 251 ? 93.435  81.881  72.818  1.00 85.73 ? 251 GLY A N   1 
ATOM 1248 C CA  . GLY A 1 251 ? 93.534  80.766  71.879  1.00 82.45 ? 251 GLY A CA  1 
ATOM 1249 C C   . GLY A 1 251 ? 94.438  81.054  70.676  1.00 80.79 ? 251 GLY A C   1 
ATOM 1250 O O   . GLY A 1 251 ? 95.058  82.104  70.576  1.00 74.22 ? 251 GLY A O   1 
ATOM 1251 N N   . ARG A 1 252 ? 94.510  80.091  69.743  1.00 75.39 ? 252 ARG A N   1 
ATOM 1252 C CA  . ARG A 1 252 ? 95.425  80.146  68.581  1.00 70.77 ? 252 ARG A CA  1 
ATOM 1253 C C   . ARG A 1 252 ? 94.972  81.087  67.466  1.00 69.53 ? 252 ARG A C   1 
ATOM 1254 O O   . ARG A 1 252 ? 95.807  81.576  66.714  1.00 61.69 ? 252 ARG A O   1 
ATOM 1255 C CB  . ARG A 1 252 ? 95.635  78.744  67.989  1.00 64.12 ? 252 ARG A CB  1 
ATOM 1256 C CG  . ARG A 1 252 ? 96.495  77.854  68.892  1.00 56.51 ? 252 ARG A CG  1 
ATOM 1257 C CD  . ARG A 1 252 ? 96.791  76.510  68.206  1.00 51.84 ? 252 ARG A CD  1 
ATOM 1258 N NE  . ARG A 1 252 ? 97.654  75.670  69.046  1.00 46.13 ? 252 ARG A NE  1 
ATOM 1259 C CZ  . ARG A 1 252 ? 98.024  74.423  68.815  1.00 40.81 ? 252 ARG A CZ  1 
ATOM 1260 N NH1 . ARG A 1 252 ? 97.647  73.781  67.739  1.00 37.81 ? 252 ARG A NH1 1 
ATOM 1261 N NH2 . ARG A 1 252 ? 98.786  73.799  69.669  1.00 35.66 ? 252 ARG A NH2 1 
ATOM 1262 N N   . ASP A 1 253 ? 93.674  81.261  67.331  1.00 64.86 ? 253 ASP A N   1 
ATOM 1263 C CA  . ASP A 1 253 ? 93.057  82.107  66.302  1.00 63.42 ? 253 ASP A CA  1 
ATOM 1264 C C   . ASP A 1 253 ? 92.094  83.086  66.982  1.00 66.73 ? 253 ASP A C   1 
ATOM 1265 O O   . ASP A 1 253 ? 90.881  82.878  67.023  1.00 60.53 ? 253 ASP A O   1 
ATOM 1266 C CB  . ASP A 1 253 ? 92.387  81.240  65.225  1.00 54.73 ? 253 ASP A CB  1 
ATOM 1267 C CG  . ASP A 1 253 ? 91.976  82.062  63.994  1.00 47.66 ? 253 ASP A CG  1 
ATOM 1268 O OD1 . ASP A 1 253 ? 92.276  83.279  63.953  1.00 42.10 ? 253 ASP A OD1 1 
ATOM 1269 O OD2 . ASP A 1 253 ? 91.389  81.445  63.073  1.00 41.56 ? 253 ASP A OD2 1 
ATOM 1270 N N   . PRO A 1 254 ? 92.639  84.121  67.602  1.00 71.01 ? 254 PRO A N   1 
ATOM 1271 C CA  . PRO A 1 254 ? 91.862  84.944  68.517  1.00 69.60 ? 254 PRO A CA  1 
ATOM 1272 C C   . PRO A 1 254 ? 90.883  85.902  67.836  1.00 72.33 ? 254 PRO A C   1 
ATOM 1273 O O   . PRO A 1 254 ? 89.927  86.338  68.467  1.00 67.41 ? 254 PRO A O   1 
ATOM 1274 C CB  . PRO A 1 254 ? 92.915  85.698  69.336  1.00 63.94 ? 254 PRO A CB  1 
ATOM 1275 C CG  . PRO A 1 254 ? 94.115  85.793  68.404  1.00 63.01 ? 254 PRO A CG  1 
ATOM 1276 C CD  . PRO A 1 254 ? 94.056  84.486  67.632  1.00 66.17 ? 254 PRO A CD  1 
ATOM 1277 N N   . GLY A 1 255 ? 91.155  86.277  66.581  1.00 77.71 ? 255 GLY A N   1 
ATOM 1278 C CA  . GLY A 1 255 ? 90.491  87.446  65.990  1.00 80.70 ? 255 GLY A CA  1 
ATOM 1279 C C   . GLY A 1 255 ? 90.854  88.776  66.670  1.00 84.91 ? 255 GLY A C   1 
ATOM 1280 O O   . GLY A 1 255 ? 90.195  89.782  66.428  1.00 82.74 ? 255 GLY A O   1 
ATOM 1281 N N   . LEU A 1 256 ? 91.883  88.785  67.524  1.00 88.45 ? 256 LEU A N   1 
ATOM 1282 C CA  . LEU A 1 256 ? 92.379  89.943  68.249  1.00 90.49 ? 256 LEU A CA  1 
ATOM 1283 C C   . LEU A 1 256 ? 93.807  90.292  67.803  1.00 89.93 ? 256 LEU A C   1 
ATOM 1284 O O   . LEU A 1 256 ? 94.621  89.412  67.546  1.00 88.44 ? 256 LEU A O   1 
ATOM 1285 C CB  . LEU A 1 256 ? 92.334  89.674  69.763  1.00 91.13 ? 256 LEU A CB  1 
ATOM 1286 C CG  . LEU A 1 256 ? 90.926  89.499  70.360  1.00 91.73 ? 256 LEU A CG  1 
ATOM 1287 C CD1 . LEU A 1 256 ? 91.032  89.092  71.823  1.00 88.92 ? 256 LEU A CD1 1 
ATOM 1288 C CD2 . LEU A 1 256 ? 90.106  90.787  70.274  1.00 88.99 ? 256 LEU A CD2 1 
ATOM 1289 N N   . ILE A 1 257 ? 94.108  91.587  67.776  1.00 91.12 ? 257 ILE A N   1 
ATOM 1290 C CA  . ILE A 1 257 ? 95.455  92.104  67.548  1.00 90.73 ? 257 ILE A CA  1 
ATOM 1291 C C   . ILE A 1 257 ? 96.203  92.064  68.881  1.00 91.75 ? 257 ILE A C   1 
ATOM 1292 O O   . ILE A 1 257 ? 95.696  92.588  69.876  1.00 91.30 ? 257 ILE A O   1 
ATOM 1293 C CB  . ILE A 1 257 ? 95.413  93.539  66.991  1.00 88.54 ? 257 ILE A CB  1 
ATOM 1294 C CG1 . ILE A 1 257 ? 94.538  93.642  65.723  1.00 80.42 ? 257 ILE A CG1 1 
ATOM 1295 C CG2 . ILE A 1 257 ? 96.835  94.041  66.682  1.00 78.33 ? 257 ILE A CG2 1 
ATOM 1296 C CD1 . ILE A 1 257 ? 94.005  95.057  65.515  1.00 70.40 ? 257 ILE A CD1 1 
ATOM 1297 N N   . GLN A 1 258 ? 97.399  91.479  68.897  1.00 90.67 ? 258 GLN A N   1 
ATOM 1298 C CA  . GLN A 1 258 ? 98.289  91.569  70.045  1.00 89.93 ? 258 GLN A CA  1 
ATOM 1299 C C   . GLN A 1 258 ? 99.080  92.881  69.976  1.00 89.53 ? 258 GLN A C   1 
ATOM 1300 O O   . GLN A 1 258 ? 99.800  93.128  69.005  1.00 88.36 ? 258 GLN A O   1 
ATOM 1301 C CB  . GLN A 1 258 ? 99.189  90.333  70.102  1.00 88.10 ? 258 GLN A CB  1 
ATOM 1302 C CG  . GLN A 1 258 ? 100.064 90.321  71.364  1.00 83.91 ? 258 GLN A CG  1 
ATOM 1303 C CD  . GLN A 1 258 ? 100.978 89.093  71.440  1.00 82.72 ? 258 GLN A CD  1 
ATOM 1304 O OE1 . GLN A 1 258 ? 100.674 88.003  70.988  1.00 76.66 ? 258 GLN A OE1 1 
ATOM 1305 N NE2 . GLN A 1 258 ? 102.132 89.240  72.035  1.00 74.50 ? 258 GLN A NE2 1 
ATOM 1306 N N   . LEU A 1 259 ? 98.960  93.708  71.008  1.00 91.35 ? 259 LEU A N   1 
ATOM 1307 C CA  . LEU A 1 259 ? 99.612  95.005  71.092  1.00 91.12 ? 259 LEU A CA  1 
ATOM 1308 C C   . LEU A 1 259 ? 100.992 94.883  71.738  1.00 89.78 ? 259 LEU A C   1 
ATOM 1309 O O   . LEU A 1 259 ? 101.130 94.319  72.829  1.00 86.88 ? 259 LEU A O   1 
ATOM 1310 C CB  . LEU A 1 259 ? 98.715  95.981  71.865  1.00 91.44 ? 259 LEU A CB  1 
ATOM 1311 C CG  . LEU A 1 259 ? 97.281  96.136  71.322  1.00 91.54 ? 259 LEU A CG  1 
ATOM 1312 C CD1 . LEU A 1 259 ? 96.517  97.132  72.185  1.00 87.18 ? 259 LEU A CD1 1 
ATOM 1313 C CD2 . LEU A 1 259 ? 97.252  96.631  69.879  1.00 86.66 ? 259 LEU A CD2 1 
ATOM 1314 N N   . SER A 1 260 ? 102.003 95.451  71.078  1.00 87.57 ? 260 SER A N   1 
ATOM 1315 C CA  . SER A 1 260 ? 103.370 95.492  71.582  1.00 85.47 ? 260 SER A CA  1 
ATOM 1316 C C   . SER A 1 260 ? 103.631 96.808  72.310  1.00 86.07 ? 260 SER A C   1 
ATOM 1317 O O   . SER A 1 260 ? 104.100 97.777  71.713  1.00 80.32 ? 260 SER A O   1 
ATOM 1318 C CB  . SER A 1 260 ? 104.363 95.281  70.434  1.00 79.83 ? 260 SER A CB  1 
ATOM 1319 O OG  . SER A 1 260 ? 104.233 93.970  69.926  1.00 67.84 ? 260 SER A OG  1 
ATOM 1320 N N   . LEU A 1 261 ? 103.355 96.851  73.621  1.00 87.99 ? 261 LEU A N   1 
ATOM 1321 C CA  . LEU A 1 261 ? 103.494 98.066  74.433  1.00 88.11 ? 261 LEU A CA  1 
ATOM 1322 C C   . LEU A 1 261 ? 104.893 98.265  75.037  1.00 86.27 ? 261 LEU A C   1 
ATOM 1323 O O   . LEU A 1 261 ? 105.068 99.084  75.939  1.00 78.55 ? 261 LEU A O   1 
ATOM 1324 C CB  . LEU A 1 261 ? 102.398 98.096  75.510  1.00 87.51 ? 261 LEU A CB  1 
ATOM 1325 C CG  . LEU A 1 261 ? 100.960 98.039  74.971  1.00 88.74 ? 261 LEU A CG  1 
ATOM 1326 C CD1 . LEU A 1 261 ? 99.984  98.111  76.143  1.00 83.25 ? 261 LEU A CD1 1 
ATOM 1327 C CD2 . LEU A 1 261 ? 100.644 99.187  74.011  1.00 83.91 ? 261 LEU A CD2 1 
ATOM 1328 N N   . ALA A 1 262 ? 105.904 97.521  74.554  1.00 83.62 ? 262 ALA A N   1 
ATOM 1329 C CA  . ALA A 1 262 ? 107.265 97.520  75.105  1.00 81.81 ? 262 ALA A CA  1 
ATOM 1330 C C   . ALA A 1 262 ? 107.320 97.235  76.625  1.00 82.91 ? 262 ALA A C   1 
ATOM 1331 O O   . ALA A 1 262 ? 108.162 97.767  77.341  1.00 76.55 ? 262 ALA A O   1 
ATOM 1332 C CB  . ALA A 1 262 ? 108.001 98.798  74.684  1.00 76.46 ? 262 ALA A CB  1 
ATOM 1333 N N   . ALA A 1 263 ? 106.420 96.393  77.105  1.00 83.86 ? 263 ALA A N   1 
ATOM 1334 C CA  . ALA A 1 263 ? 106.351 95.963  78.495  1.00 83.66 ? 263 ALA A CA  1 
ATOM 1335 C C   . ALA A 1 263 ? 106.118 94.448  78.573  1.00 84.62 ? 263 ALA A C   1 
ATOM 1336 O O   . ALA A 1 263 ? 105.280 93.912  77.849  1.00 79.34 ? 263 ALA A O   1 
ATOM 1337 C CB  . ALA A 1 263 ? 105.239 96.736  79.196  1.00 78.66 ? 263 ALA A CB  1 
ATOM 1338 N N   . ASP A 1 264 ? 106.837 93.790  79.480  1.00 84.36 ? 264 ASP A N   1 
ATOM 1339 C CA  . ASP A 1 264 ? 106.638 92.379  79.779  1.00 84.47 ? 264 ASP A CA  1 
ATOM 1340 C C   . ASP A 1 264 ? 105.684 92.217  80.961  1.00 86.95 ? 264 ASP A C   1 
ATOM 1341 O O   . ASP A 1 264 ? 105.853 92.832  82.018  1.00 83.47 ? 264 ASP A O   1 
ATOM 1342 C CB  . ASP A 1 264 ? 107.983 91.685  80.054  1.00 77.71 ? 264 ASP A CB  1 
ATOM 1343 C CG  . ASP A 1 264 ? 108.796 91.417  78.793  1.00 67.78 ? 264 ASP A CG  1 
ATOM 1344 O OD1 . ASP A 1 264 ? 108.190 91.007  77.776  1.00 59.02 ? 264 ASP A OD1 1 
ATOM 1345 O OD2 . ASP A 1 264 ? 110.043 91.554  78.863  1.00 59.26 ? 264 ASP A OD2 1 
ATOM 1346 N N   . ILE A 1 265 ? 104.688 91.356  80.790  1.00 88.32 ? 265 ILE A N   1 
ATOM 1347 C CA  . ILE A 1 265 ? 103.790 90.917  81.855  1.00 90.28 ? 265 ILE A CA  1 
ATOM 1348 C C   . ILE A 1 265 ? 104.310 89.573  82.372  1.00 90.03 ? 265 ILE A C   1 
ATOM 1349 O O   . ILE A 1 265 ? 104.637 88.703  81.559  1.00 87.64 ? 265 ILE A O   1 
ATOM 1350 C CB  . ILE A 1 265 ? 102.336 90.824  81.339  1.00 90.15 ? 265 ILE A CB  1 
ATOM 1351 C CG1 . ILE A 1 265 ? 101.892 92.151  80.687  1.00 86.73 ? 265 ILE A CG1 1 
ATOM 1352 C CG2 . ILE A 1 265 ? 101.400 90.459  82.505  1.00 85.67 ? 265 ILE A CG2 1 
ATOM 1353 C CD1 . ILE A 1 265 ? 100.543 92.061  79.964  1.00 81.60 ? 265 ILE A CD1 1 
ATOM 1354 N N   . PRO A 1 266 ? 104.402 89.372  83.690  1.00 89.54 ? 266 PRO A N   1 
ATOM 1355 C CA  . PRO A 1 266 ? 104.890 88.108  84.241  1.00 88.87 ? 266 PRO A CA  1 
ATOM 1356 C C   . PRO A 1 266 ? 104.106 86.898  83.729  1.00 89.81 ? 266 PRO A C   1 
ATOM 1357 O O   . PRO A 1 266 ? 102.877 86.892  83.711  1.00 88.15 ? 266 PRO A O   1 
ATOM 1358 C CB  . PRO A 1 266 ? 104.800 88.251  85.758  1.00 86.15 ? 266 PRO A CB  1 
ATOM 1359 C CG  . PRO A 1 266 ? 104.875 89.762  85.981  1.00 84.16 ? 266 PRO A CG  1 
ATOM 1360 C CD  . PRO A 1 266 ? 104.155 90.325  84.759  1.00 87.36 ? 266 PRO A CD  1 
ATOM 1361 N N   . SER A 1 267 ? 104.832 85.844  83.351  1.00 90.35 ? 267 SER A N   1 
ATOM 1362 C CA  . SER A 1 267 ? 104.243 84.532  83.090  1.00 90.45 ? 267 SER A CA  1 
ATOM 1363 C C   . SER A 1 267 ? 104.072 83.738  84.388  1.00 90.77 ? 267 SER A C   1 
ATOM 1364 O O   . SER A 1 267 ? 104.753 83.992  85.384  1.00 89.33 ? 267 SER A O   1 
ATOM 1365 C CB  . SER A 1 267 ? 105.080 83.764  82.062  1.00 88.16 ? 267 SER A CB  1 
ATOM 1366 O OG  . SER A 1 267 ? 106.368 83.462  82.561  1.00 81.00 ? 267 SER A OG  1 
ATOM 1367 N N   . PHE A 1 268 ? 103.197 82.745  84.366  1.00 91.19 ? 268 PHE A N   1 
ATOM 1368 C CA  . PHE A 1 268 ? 103.002 81.832  85.481  1.00 91.45 ? 268 PHE A CA  1 
ATOM 1369 C C   . PHE A 1 268 ? 102.787 80.404  84.988  1.00 91.82 ? 268 PHE A C   1 
ATOM 1370 O O   . PHE A 1 268 ? 102.378 80.175  83.848  1.00 90.74 ? 268 PHE A O   1 
ATOM 1371 C CB  . PHE A 1 268 ? 101.854 82.326  86.380  1.00 90.19 ? 268 PHE A CB  1 
ATOM 1372 C CG  . PHE A 1 268 ? 100.514 82.457  85.678  1.00 90.17 ? 268 PHE A CG  1 
ATOM 1373 C CD1 . PHE A 1 268 ? 100.164 83.670  85.054  1.00 86.00 ? 268 PHE A CD1 1 
ATOM 1374 C CD2 . PHE A 1 268 ? 99.610  81.382  85.667  1.00 86.51 ? 268 PHE A CD2 1 
ATOM 1375 C CE1 . PHE A 1 268 ? 98.917  83.811  84.433  1.00 84.50 ? 268 PHE A CE1 1 
ATOM 1376 C CE2 . PHE A 1 268 ? 98.361  81.513  85.039  1.00 84.62 ? 268 PHE A CE2 1 
ATOM 1377 C CZ  . PHE A 1 268 ? 98.016  82.731  84.427  1.00 86.21 ? 268 PHE A CZ  1 
ATOM 1378 N N   . ASP A 1 269 ? 103.077 79.432  85.848  1.00 92.12 ? 269 ASP A N   1 
ATOM 1379 C CA  . ASP A 1 269 ? 102.918 78.024  85.517  1.00 92.77 ? 269 ASP A CA  1 
ATOM 1380 C C   . ASP A 1 269 ? 101.587 77.471  86.040  1.00 93.24 ? 269 ASP A C   1 
ATOM 1381 O O   . ASP A 1 269 ? 101.152 77.788  87.145  1.00 92.31 ? 269 ASP A O   1 
ATOM 1382 C CB  . ASP A 1 269 ? 104.107 77.236  86.065  1.00 91.64 ? 269 ASP A CB  1 
ATOM 1383 C CG  . ASP A 1 269 ? 105.420 77.489  85.339  1.00 90.70 ? 269 ASP A CG  1 
ATOM 1384 O OD1 . ASP A 1 269 ? 105.434 77.704  84.107  1.00 86.74 ? 269 ASP A OD1 1 
ATOM 1385 O OD2 . ASP A 1 269 ? 106.494 77.266  85.947  1.00 86.27 ? 269 ASP A OD2 1 
ATOM 1386 N N   . THR A 1 270 ? 100.986 76.570  85.255  1.00 94.41 ? 270 THR A N   1 
ATOM 1387 C CA  . THR A 1 270 ? 99.847  75.760  85.678  1.00 94.74 ? 270 THR A CA  1 
ATOM 1388 C C   . THR A 1 270 ? 100.297 74.380  86.146  1.00 94.83 ? 270 THR A C   1 
ATOM 1389 O O   . THR A 1 270 ? 101.288 73.825  85.663  1.00 93.94 ? 270 THR A O   1 
ATOM 1390 C CB  . THR A 1 270 ? 98.782  75.631  84.584  1.00 94.01 ? 270 THR A CB  1 
ATOM 1391 O OG1 . THR A 1 270 ? 99.335  75.060  83.429  1.00 86.52 ? 270 THR A OG1 1 
ATOM 1392 C CG2 . THR A 1 270 ? 98.195  76.988  84.198  1.00 85.51 ? 270 THR A CG2 1 
ATOM 1393 N N   . TYR A 1 271 ? 99.537  73.804  87.075  1.00 95.16 ? 271 TYR A N   1 
ATOM 1394 C CA  . TYR A 1 271 ? 99.836  72.508  87.678  1.00 95.43 ? 271 TYR A CA  1 
ATOM 1395 C C   . TYR A 1 271 ? 98.589  71.634  87.737  1.00 95.60 ? 271 TYR A C   1 
ATOM 1396 O O   . TYR A 1 271 ? 97.522  72.085  88.143  1.00 94.77 ? 271 TYR A O   1 
ATOM 1397 C CB  . TYR A 1 271 ? 100.416 72.706  89.085  1.00 95.00 ? 271 TYR A CB  1 
ATOM 1398 C CG  . TYR A 1 271 ? 101.749 73.410  89.104  1.00 94.62 ? 271 TYR A CG  1 
ATOM 1399 C CD1 . TYR A 1 271 ? 102.955 72.688  89.156  1.00 91.88 ? 271 TYR A CD1 1 
ATOM 1400 C CD2 . TYR A 1 271 ? 101.806 74.825  89.028  1.00 92.33 ? 271 TYR A CD2 1 
ATOM 1401 C CE1 . TYR A 1 271 ? 104.196 73.341  89.130  1.00 91.35 ? 271 TYR A CE1 1 
ATOM 1402 C CE2 . TYR A 1 271 ? 103.040 75.493  88.991  1.00 91.24 ? 271 TYR A CE2 1 
ATOM 1403 C CZ  . TYR A 1 271 ? 104.228 74.740  89.037  1.00 92.29 ? 271 TYR A CZ  1 
ATOM 1404 O OH  . TYR A 1 271 ? 105.438 75.394  88.991  1.00 90.52 ? 271 TYR A OH  1 
ATOM 1405 N N   . PHE A 1 272 ? 98.744  70.352  87.387  1.00 95.50 ? 272 PHE A N   1 
ATOM 1406 C CA  . PHE A 1 272 ? 97.773  69.316  87.709  1.00 95.78 ? 272 PHE A CA  1 
ATOM 1407 C C   . PHE A 1 272 ? 98.136  68.701  89.057  1.00 95.47 ? 272 PHE A C   1 
ATOM 1408 O O   . PHE A 1 272 ? 99.295  68.328  89.267  1.00 94.54 ? 272 PHE A O   1 
ATOM 1409 C CB  . PHE A 1 272 ? 97.742  68.267  86.595  1.00 95.78 ? 272 PHE A CB  1 
ATOM 1410 C CG  . PHE A 1 272 ? 96.676  67.211  86.801  1.00 96.25 ? 272 PHE A CG  1 
ATOM 1411 C CD1 . PHE A 1 272 ? 96.999  65.966  87.382  1.00 94.07 ? 272 PHE A CD1 1 
ATOM 1412 C CD2 . PHE A 1 272 ? 95.353  67.474  86.422  1.00 94.28 ? 272 PHE A CD2 1 
ATOM 1413 C CE1 . PHE A 1 272 ? 96.005  64.998  87.570  1.00 93.94 ? 272 PHE A CE1 1 
ATOM 1414 C CE2 . PHE A 1 272 ? 94.350  66.498  86.607  1.00 93.88 ? 272 PHE A CE2 1 
ATOM 1415 C CZ  . PHE A 1 272 ? 94.680  65.264  87.179  1.00 95.33 ? 272 PHE A CZ  1 
ATOM 1416 N N   . CYS A 1 273 ? 97.171  68.571  89.947  1.00 95.51 ? 273 CYS A N   1 
ATOM 1417 C CA  . CYS A 1 273 ? 97.390  67.966  91.258  1.00 95.20 ? 273 CYS A CA  1 
ATOM 1418 C C   . CYS A 1 273 ? 96.222  67.071  91.689  1.00 95.54 ? 273 CYS A C   1 
ATOM 1419 O O   . CYS A 1 273 ? 95.085  67.237  91.252  1.00 94.77 ? 273 CYS A O   1 
ATOM 1420 C CB  . CYS A 1 273 ? 97.719  69.057  92.283  1.00 93.10 ? 273 CYS A CB  1 
ATOM 1421 S SG  . CYS A 1 273 ? 96.322  70.186  92.567  1.00 86.61 ? 273 CYS A SG  1 
ATOM 1422 N N   . TYR A 1 274 ? 96.536  66.106  92.537  1.00 94.56 ? 274 TYR A N   1 
ATOM 1423 C CA  . TYR A 1 274 ? 95.580  65.136  93.065  1.00 94.48 ? 274 TYR A CA  1 
ATOM 1424 C C   . TYR A 1 274 ? 96.103  64.526  94.377  1.00 94.09 ? 274 TYR A C   1 
ATOM 1425 O O   . TYR A 1 274 ? 97.324  64.451  94.567  1.00 92.78 ? 274 TYR A O   1 
ATOM 1426 C CB  . TYR A 1 274 ? 95.302  64.046  92.020  1.00 93.93 ? 274 TYR A CB  1 
ATOM 1427 C CG  . TYR A 1 274 ? 96.526  63.310  91.509  1.00 94.11 ? 274 TYR A CG  1 
ATOM 1428 C CD1 . TYR A 1 274 ? 97.295  63.850  90.456  1.00 92.01 ? 274 TYR A CD1 1 
ATOM 1429 C CD2 . TYR A 1 274 ? 96.907  62.080  92.082  1.00 92.06 ? 274 TYR A CD2 1 
ATOM 1430 C CE1 . TYR A 1 274 ? 98.429  63.186  89.982  1.00 91.14 ? 274 TYR A CE1 1 
ATOM 1431 C CE2 . TYR A 1 274 ? 98.051  61.400  91.612  1.00 91.02 ? 274 TYR A CE2 1 
ATOM 1432 C CZ  . TYR A 1 274 ? 98.804  61.959  90.562  1.00 91.62 ? 274 TYR A CZ  1 
ATOM 1433 O OH  . TYR A 1 274 ? 99.911  61.300  90.098  1.00 90.11 ? 274 TYR A OH  1 
ATOM 1434 N N   . PRO A 1 275 ? 95.226  64.081  95.283  1.00 92.74 ? 275 PRO A N   1 
ATOM 1435 C CA  . PRO A 1 275 ? 95.641  63.453  96.532  1.00 91.63 ? 275 PRO A CA  1 
ATOM 1436 C C   . PRO A 1 275 ? 96.237  62.057  96.282  1.00 91.23 ? 275 PRO A C   1 
ATOM 1437 O O   . PRO A 1 275 ? 95.846  61.355  95.346  1.00 89.57 ? 275 PRO A O   1 
ATOM 1438 C CB  . PRO A 1 275 ? 94.376  63.403  97.387  1.00 89.60 ? 275 PRO A CB  1 
ATOM 1439 C CG  . PRO A 1 275 ? 93.254  63.321  96.352  1.00 87.03 ? 275 PRO A CG  1 
ATOM 1440 C CD  . PRO A 1 275 ? 93.775  64.157  95.198  1.00 90.67 ? 275 PRO A CD  1 
ATOM 1441 N N   . ASP A 1 276 ? 97.159  61.620  97.145  1.00 89.83 ? 276 ASP A N   1 
ATOM 1442 C CA  . ASP A 1 276 ? 97.827  60.320  97.023  1.00 88.61 ? 276 ASP A CA  1 
ATOM 1443 C C   . ASP A 1 276 ? 96.838  59.132  97.008  1.00 88.02 ? 276 ASP A C   1 
ATOM 1444 O O   . ASP A 1 276 ? 97.075  58.128  96.342  1.00 84.06 ? 276 ASP A O   1 
ATOM 1445 C CB  . ASP A 1 276 ? 98.850  60.162  98.161  1.00 86.25 ? 276 ASP A CB  1 
ATOM 1446 C CG  . ASP A 1 276 ? 99.767  58.947  97.953  1.00 80.05 ? 276 ASP A CG  1 
ATOM 1447 O OD1 . ASP A 1 276 ? 100.589 58.971  97.014  1.00 71.93 ? 276 ASP A OD1 1 
ATOM 1448 O OD2 . ASP A 1 276 ? 99.668  57.935  98.677  1.00 70.66 ? 276 ASP A OD2 1 
ATOM 1449 N N   . GLU A 1 277 ? 95.689  59.299  97.656  1.00 87.63 ? 277 GLU A N   1 
ATOM 1450 C CA  . GLU A 1 277 ? 94.589  58.326  97.682  1.00 85.97 ? 277 GLU A CA  1 
ATOM 1451 C C   . GLU A 1 277 ? 94.109  57.952  96.271  1.00 86.69 ? 277 GLU A C   1 
ATOM 1452 O O   . GLU A 1 277 ? 93.708  56.817  96.016  1.00 84.12 ? 277 GLU A O   1 
ATOM 1453 C CB  . GLU A 1 277 ? 93.393  58.899  98.456  1.00 82.60 ? 277 GLU A CB  1 
ATOM 1454 C CG  . GLU A 1 277 ? 93.722  59.429  99.866  1.00 72.26 ? 277 GLU A CG  1 
ATOM 1455 C CD  . GLU A 1 277 ? 92.489  60.033  100.563 1.00 67.10 ? 277 GLU A CD  1 
ATOM 1456 O OE1 . GLU A 1 277 ? 92.657  61.009  101.311 1.00 58.94 ? 277 GLU A OE1 1 
ATOM 1457 O OE2 . GLU A 1 277 ? 91.353  59.522  100.361 1.00 60.66 ? 277 GLU A OE2 1 
ATOM 1458 N N   . MET A 1 278 ? 94.171  58.910  95.333  1.00 86.59 ? 278 MET A N   1 
ATOM 1459 C CA  . MET A 1 278 ? 93.665  58.757  93.969  1.00 86.75 ? 278 MET A CA  1 
ATOM 1460 C C   . MET A 1 278 ? 94.712  58.214  92.985  1.00 87.73 ? 278 MET A C   1 
ATOM 1461 O O   . MET A 1 278 ? 94.360  57.856  91.862  1.00 85.82 ? 278 MET A O   1 
ATOM 1462 C CB  . MET A 1 278 ? 93.091  60.095  93.481  1.00 85.15 ? 278 MET A CB  1 
ATOM 1463 C CG  . MET A 1 278 ? 91.799  60.498  94.215  1.00 81.15 ? 278 MET A CG  1 
ATOM 1464 S SD  . MET A 1 278 ? 90.371  59.398  93.945  1.00 79.20 ? 278 MET A SD  1 
ATOM 1465 C CE  . MET A 1 278 ? 90.039  59.704  92.201  1.00 70.41 ? 278 MET A CE  1 
ATOM 1466 N N   . LYS A 1 279 ? 95.989  58.090  93.375  1.00 87.72 ? 279 LYS A N   1 
ATOM 1467 C CA  . LYS A 1 279 ? 97.105  57.768  92.464  1.00 87.35 ? 279 LYS A CA  1 
ATOM 1468 C C   . LYS A 1 279 ? 96.963  56.459  91.690  1.00 87.66 ? 279 LYS A C   1 
ATOM 1469 O O   . LYS A 1 279 ? 97.571  56.296  90.634  1.00 84.67 ? 279 LYS A O   1 
ATOM 1470 C CB  . LYS A 1 279 ? 98.430  57.783  93.247  1.00 85.29 ? 279 LYS A CB  1 
ATOM 1471 C CG  . LYS A 1 279 ? 98.663  56.531  94.115  1.00 81.77 ? 279 LYS A CG  1 
ATOM 1472 C CD  . LYS A 1 279 ? 99.902  56.740  94.980  1.00 80.03 ? 279 LYS A CD  1 
ATOM 1473 C CE  . LYS A 1 279 ? 100.051 55.649  96.031  1.00 70.97 ? 279 LYS A CE  1 
ATOM 1474 N NZ  . LYS A 1 279 ? 100.982 56.100  97.092  1.00 65.08 ? 279 LYS A NZ  1 
ATOM 1475 N N   . ASN A 1 280 ? 96.189  55.517  92.217  1.00 87.71 ? 280 ASN A N   1 
ATOM 1476 C CA  . ASN A 1 280 ? 95.987  54.202  91.620  1.00 87.23 ? 280 ASN A CA  1 
ATOM 1477 C C   . ASN A 1 280 ? 94.649  54.065  90.884  1.00 87.50 ? 280 ASN A C   1 
ATOM 1478 O O   . ASN A 1 280 ? 94.444  53.054  90.207  1.00 84.14 ? 280 ASN A O   1 
ATOM 1479 C CB  . ASN A 1 280 ? 96.180  53.129  92.701  1.00 85.47 ? 280 ASN A CB  1 
ATOM 1480 C CG  . ASN A 1 280 ? 97.624  52.998  93.142  1.00 83.39 ? 280 ASN A CG  1 
ATOM 1481 O OD1 . ASN A 1 280 ? 98.562  53.159  92.380  1.00 75.82 ? 280 ASN A OD1 1 
ATOM 1482 N ND2 . ASN A 1 280 ? 97.858  52.668  94.404  1.00 74.32 ? 280 ASN A ND2 1 
ATOM 1483 N N   . ALA A 1 281 ? 93.757  55.036  90.976  1.00 89.32 ? 281 ALA A N   1 
ATOM 1484 C CA  . ALA A 1 281 ? 92.472  55.005  90.292  1.00 89.33 ? 281 ALA A CA  1 
ATOM 1485 C C   . ALA A 1 281 ? 92.659  55.105  88.770  1.00 90.15 ? 281 ALA A C   1 
ATOM 1486 O O   . ALA A 1 281 ? 93.200  56.094  88.281  1.00 89.01 ? 281 ALA A O   1 
ATOM 1487 C CB  . ALA A 1 281 ? 91.584  56.122  90.845  1.00 87.34 ? 281 ALA A CB  1 
ATOM 1488 N N   . ALA A 1 282 ? 92.181  54.107  88.024  1.00 88.79 ? 282 ALA A N   1 
ATOM 1489 C CA  . ALA A 1 282 ? 92.307  54.061  86.564  1.00 88.44 ? 282 ALA A CA  1 
ATOM 1490 C C   . ALA A 1 282 ? 91.723  55.319  85.896  1.00 89.51 ? 282 ALA A C   1 
ATOM 1491 O O   . ALA A 1 282 ? 92.388  55.951  85.082  1.00 88.62 ? 282 ALA A O   1 
ATOM 1492 C CB  . ALA A 1 282 ? 91.634  52.781  86.058  1.00 85.95 ? 282 ALA A CB  1 
ATOM 1493 N N   . LYS A 1 283 ? 90.534  55.750  86.323  1.00 91.35 ? 283 LYS A N   1 
ATOM 1494 C CA  . LYS A 1 283 ? 89.878  56.980  85.856  1.00 92.18 ? 283 LYS A CA  1 
ATOM 1495 C C   . LYS A 1 283 ? 90.751  58.238  86.008  1.00 92.76 ? 283 LYS A C   1 
ATOM 1496 O O   . LYS A 1 283 ? 90.759  59.086  85.127  1.00 92.01 ? 283 LYS A O   1 
ATOM 1497 C CB  . LYS A 1 283 ? 88.511  57.142  86.547  1.00 90.55 ? 283 LYS A CB  1 
ATOM 1498 C CG  . LYS A 1 283 ? 88.580  57.344  88.072  1.00 87.35 ? 283 LYS A CG  1 
ATOM 1499 C CD  . LYS A 1 283 ? 87.189  57.573  88.691  1.00 85.86 ? 283 LYS A CD  1 
ATOM 1500 C CE  . LYS A 1 283 ? 87.340  57.907  90.186  1.00 78.08 ? 283 LYS A CE  1 
ATOM 1501 N NZ  . LYS A 1 283 ? 86.108  58.468  90.775  1.00 73.63 ? 283 LYS A NZ  1 
ATOM 1502 N N   . LEU A 1 284 ? 91.516  58.346  87.100  1.00 92.59 ? 284 LEU A N   1 
ATOM 1503 C CA  . LEU A 1 284 ? 92.407  59.478  87.322  1.00 93.12 ? 284 LEU A CA  1 
ATOM 1504 C C   . LEU A 1 284 ? 93.673  59.382  86.464  1.00 93.09 ? 284 LEU A C   1 
ATOM 1505 O O   . LEU A 1 284 ? 94.120  60.389  85.934  1.00 91.92 ? 284 LEU A O   1 
ATOM 1506 C CB  . LEU A 1 284 ? 92.769  59.587  88.814  1.00 92.76 ? 284 LEU A CB  1 
ATOM 1507 C CG  . LEU A 1 284 ? 93.728  60.766  89.106  1.00 91.39 ? 284 LEU A CG  1 
ATOM 1508 C CD1 . LEU A 1 284 ? 93.044  62.118  88.955  1.00 84.63 ? 284 LEU A CD1 1 
ATOM 1509 C CD2 . LEU A 1 284 ? 94.274  60.657  90.513  1.00 83.86 ? 284 LEU A CD2 1 
ATOM 1510 N N   . LYS A 1 285 ? 94.254  58.184  86.321  1.00 91.03 ? 285 LYS A N   1 
ATOM 1511 C CA  . LYS A 1 285 ? 95.426  57.971  85.461  1.00 89.86 ? 285 LYS A CA  1 
ATOM 1512 C C   . LYS A 1 285 ? 95.123  58.353  84.019  1.00 90.00 ? 285 LYS A C   1 
ATOM 1513 O O   . LYS A 1 285 ? 95.870  59.143  83.447  1.00 88.79 ? 285 LYS A O   1 
ATOM 1514 C CB  . LYS A 1 285 ? 95.900  56.511  85.542  1.00 88.09 ? 285 LYS A CB  1 
ATOM 1515 C CG  . LYS A 1 285 ? 96.560  56.168  86.886  1.00 81.98 ? 285 LYS A CG  1 
ATOM 1516 C CD  . LYS A 1 285 ? 96.890  54.676  86.904  1.00 79.00 ? 285 LYS A CD  1 
ATOM 1517 C CE  . LYS A 1 285 ? 97.541  54.270  88.224  1.00 70.13 ? 285 LYS A CE  1 
ATOM 1518 N NZ  . LYS A 1 285 ? 97.587  52.796  88.356  1.00 64.22 ? 285 LYS A NZ  1 
ATOM 1519 N N   . ALA A 1 286 ? 94.004  57.865  83.483  1.00 88.64 ? 286 ALA A N   1 
ATOM 1520 C CA  . ALA A 1 286 ? 93.524  58.202  82.151  1.00 88.10 ? 286 ALA A CA  1 
ATOM 1521 C C   . ALA A 1 286 ? 93.422  59.728  81.948  1.00 88.42 ? 286 ALA A C   1 
ATOM 1522 O O   . ALA A 1 286 ? 94.037  60.287  81.046  1.00 87.67 ? 286 ALA A O   1 
ATOM 1523 C CB  . ALA A 1 286 ? 92.159  57.523  81.951  1.00 87.28 ? 286 ALA A CB  1 
ATOM 1524 N N   . PHE A 1 287 ? 92.737  60.414  82.866  1.00 92.52 ? 287 PHE A N   1 
ATOM 1525 C CA  . PHE A 1 287 ? 92.570  61.863  82.772  1.00 93.64 ? 287 PHE A CA  1 
ATOM 1526 C C   . PHE A 1 287 ? 93.890  62.620  82.960  1.00 93.18 ? 287 PHE A C   1 
ATOM 1527 O O   . PHE A 1 287 ? 94.177  63.543  82.201  1.00 92.55 ? 287 PHE A O   1 
ATOM 1528 C CB  . PHE A 1 287 ? 91.526  62.334  83.782  1.00 94.51 ? 287 PHE A CB  1 
ATOM 1529 C CG  . PHE A 1 287 ? 91.159  63.785  83.600  1.00 95.28 ? 287 PHE A CG  1 
ATOM 1530 C CD1 . PHE A 1 287 ? 91.667  64.776  84.465  1.00 93.50 ? 287 PHE A CD1 1 
ATOM 1531 C CD2 . PHE A 1 287 ? 90.335  64.177  82.525  1.00 93.60 ? 287 PHE A CD2 1 
ATOM 1532 C CE1 . PHE A 1 287 ? 91.345  66.131  84.267  1.00 93.85 ? 287 PHE A CE1 1 
ATOM 1533 C CE2 . PHE A 1 287 ? 90.009  65.532  82.321  1.00 93.94 ? 287 PHE A CE2 1 
ATOM 1534 C CZ  . PHE A 1 287 ? 90.525  66.496  83.193  1.00 95.60 ? 287 PHE A CZ  1 
ATOM 1535 N N   . ARG A 1 288 ? 94.722  62.227  83.924  1.00 92.73 ? 288 ARG A N   1 
ATOM 1536 C CA  . ARG A 1 288 ? 96.034  62.835  84.171  1.00 91.77 ? 288 ARG A CA  1 
ATOM 1537 C C   . ARG A 1 288 ? 96.928  62.758  82.936  1.00 90.79 ? 288 ARG A C   1 
ATOM 1538 O O   . ARG A 1 288 ? 97.508  63.757  82.550  1.00 89.93 ? 288 ARG A O   1 
ATOM 1539 C CB  . ARG A 1 288 ? 96.710  62.128  85.352  1.00 91.09 ? 288 ARG A CB  1 
ATOM 1540 C CG  . ARG A 1 288 ? 98.131  62.655  85.663  1.00 89.32 ? 288 ARG A CG  1 
ATOM 1541 C CD  . ARG A 1 288 ? 98.905  61.669  86.537  1.00 87.06 ? 288 ARG A CD  1 
ATOM 1542 N NE  . ARG A 1 288 ? 99.249  60.460  85.789  1.00 82.29 ? 288 ARG A NE  1 
ATOM 1543 C CZ  . ARG A 1 288 ? 99.470  59.240  86.265  1.00 80.21 ? 288 ARG A CZ  1 
ATOM 1544 N NH1 . ARG A 1 288 ? 99.492  58.987  87.540  1.00 71.56 ? 288 ARG A NH1 1 
ATOM 1545 N NH2 . ARG A 1 288 ? 99.667  58.258  85.446  1.00 75.00 ? 288 ARG A NH2 1 
ATOM 1546 N N   . ASP A 1 289 ? 97.060  61.557  82.377  1.00 87.98 ? 289 ASP A N   1 
ATOM 1547 C CA  . ASP A 1 289 ? 97.985  61.315  81.279  1.00 85.26 ? 289 ASP A CA  1 
ATOM 1548 C C   . ASP A 1 289 ? 97.512  62.026  80.006  1.00 84.35 ? 289 ASP A C   1 
ATOM 1549 O O   . ASP A 1 289 ? 98.308  62.655  79.317  1.00 82.73 ? 289 ASP A O   1 
ATOM 1550 C CB  . ASP A 1 289 ? 98.202  59.801  81.114  1.00 83.55 ? 289 ASP A CB  1 
ATOM 1551 C CG  . ASP A 1 289 ? 98.938  59.160  82.316  1.00 81.04 ? 289 ASP A CG  1 
ATOM 1552 O OD1 . ASP A 1 289 ? 99.547  59.893  83.130  1.00 78.22 ? 289 ASP A OD1 1 
ATOM 1553 O OD2 . ASP A 1 289 ? 98.931  57.919  82.467  1.00 77.48 ? 289 ASP A OD2 1 
ATOM 1554 N N   . PHE A 1 290 ? 96.192  62.055  79.776  1.00 87.94 ? 290 PHE A N   1 
ATOM 1555 C CA  . PHE A 1 290 ? 95.574  62.865  78.732  1.00 87.36 ? 290 PHE A CA  1 
ATOM 1556 C C   . PHE A 1 290 ? 95.867  64.364  78.903  1.00 87.17 ? 290 PHE A C   1 
ATOM 1557 O O   . PHE A 1 290 ? 96.368  65.001  77.976  1.00 86.57 ? 290 PHE A O   1 
ATOM 1558 C CB  . PHE A 1 290 ? 94.068  62.598  78.725  1.00 87.17 ? 290 PHE A CB  1 
ATOM 1559 C CG  . PHE A 1 290 ? 93.299  63.497  77.783  1.00 87.03 ? 290 PHE A CG  1 
ATOM 1560 C CD1 . PHE A 1 290 ? 92.731  64.704  78.248  1.00 84.53 ? 290 PHE A CD1 1 
ATOM 1561 C CD2 . PHE A 1 290 ? 93.160  63.140  76.430  1.00 84.48 ? 290 PHE A CD2 1 
ATOM 1562 C CE1 . PHE A 1 290 ? 92.042  65.544  77.364  1.00 83.91 ? 290 PHE A CE1 1 
ATOM 1563 C CE2 . PHE A 1 290 ? 92.462  63.976  75.545  1.00 83.43 ? 290 PHE A CE2 1 
ATOM 1564 C CZ  . PHE A 1 290 ? 91.910  65.178  76.016  1.00 85.71 ? 290 PHE A CZ  1 
ATOM 1565 N N   . ILE A 1 291 ? 95.607  64.933  80.075  1.00 90.34 ? 291 ILE A N   1 
ATOM 1566 C CA  . ILE A 1 291 ? 95.821  66.362  80.340  1.00 91.10 ? 291 ILE A CA  1 
ATOM 1567 C C   . ILE A 1 291 ? 97.298  66.746  80.222  1.00 89.74 ? 291 ILE A C   1 
ATOM 1568 O O   . ILE A 1 291 ? 97.614  67.768  79.619  1.00 88.43 ? 291 ILE A O   1 
ATOM 1569 C CB  . ILE A 1 291 ? 95.208  66.765  81.694  1.00 91.96 ? 291 ILE A CB  1 
ATOM 1570 C CG1 . ILE A 1 291 ? 93.667  66.821  81.618  1.00 87.53 ? 291 ILE A CG1 1 
ATOM 1571 C CG2 . ILE A 1 291 ? 95.753  68.106  82.238  1.00 88.86 ? 291 ILE A CG2 1 
ATOM 1572 C CD1 . ILE A 1 291 ? 93.062  67.953  80.758  1.00 84.22 ? 291 ILE A CD1 1 
ATOM 1573 N N   . VAL A 1 292 ? 98.207  65.920  80.750  1.00 87.53 ? 292 VAL A N   1 
ATOM 1574 C CA  . VAL A 1 292 ? 99.651  66.143  80.624  1.00 85.54 ? 292 VAL A CA  1 
ATOM 1575 C C   . VAL A 1 292 ? 100.082 66.132  79.153  1.00 83.25 ? 292 VAL A C   1 
ATOM 1576 O O   . VAL A 1 292 ? 100.845 67.002  78.735  1.00 80.85 ? 292 VAL A O   1 
ATOM 1577 C CB  . VAL A 1 292 ? 100.440 65.116  81.456  1.00 85.30 ? 292 VAL A CB  1 
ATOM 1578 C CG1 . VAL A 1 292 ? 101.945 65.142  81.164  1.00 82.53 ? 292 VAL A CG1 1 
ATOM 1579 C CG2 . VAL A 1 292 ? 100.276 65.387  82.952  1.00 83.03 ? 292 VAL A CG2 1 
ATOM 1580 N N   . ALA A 1 293 ? 99.573  65.201  78.352  1.00 82.46 ? 293 ALA A N   1 
ATOM 1581 C CA  . ALA A 1 293 ? 99.849  65.153  76.924  1.00 79.08 ? 293 ALA A CA  1 
ATOM 1582 C C   . ALA A 1 293 ? 99.305  66.397  76.197  1.00 77.94 ? 293 ALA A C   1 
ATOM 1583 O O   . ALA A 1 293 ? 100.030 67.030  75.430  1.00 75.66 ? 293 ALA A O   1 
ATOM 1584 C CB  . ALA A 1 293 ? 99.274  63.854  76.352  1.00 75.91 ? 293 ALA A CB  1 
ATOM 1585 N N   . LYS A 1 294 ? 98.061  66.807  76.482  1.00 82.32 ? 294 LYS A N   1 
ATOM 1586 C CA  . LYS A 1 294 ? 97.457  68.005  75.888  1.00 81.72 ? 294 LYS A CA  1 
ATOM 1587 C C   . LYS A 1 294 ? 98.193  69.286  76.274  1.00 81.25 ? 294 LYS A C   1 
ATOM 1588 O O   . LYS A 1 294 ? 98.420  70.128  75.409  1.00 79.21 ? 294 LYS A O   1 
ATOM 1589 C CB  . LYS A 1 294 ? 95.968  68.108  76.241  1.00 80.92 ? 294 LYS A CB  1 
ATOM 1590 C CG  . LYS A 1 294 ? 95.113  67.019  75.581  1.00 77.63 ? 294 LYS A CG  1 
ATOM 1591 C CD  . LYS A 1 294 ? 95.134  67.081  74.049  1.00 76.06 ? 294 LYS A CD  1 
ATOM 1592 C CE  . LYS A 1 294 ? 94.382  65.881  73.477  1.00 72.80 ? 294 LYS A CE  1 
ATOM 1593 N NZ  . LYS A 1 294 ? 94.241  65.971  72.010  1.00 68.63 ? 294 LYS A NZ  1 
ATOM 1594 N N   . ALA A 1 295 ? 98.622  69.399  77.520  1.00 84.20 ? 295 ALA A N   1 
ATOM 1595 C CA  . ALA A 1 295 ? 99.389  70.546  78.002  1.00 82.82 ? 295 ALA A CA  1 
ATOM 1596 C C   . ALA A 1 295 ? 100.734 70.686  77.274  1.00 79.84 ? 295 ALA A C   1 
ATOM 1597 O O   . ALA A 1 295 ? 101.077 71.777  76.839  1.00 75.73 ? 295 ALA A O   1 
ATOM 1598 C CB  . ALA A 1 295 ? 99.573  70.389  79.506  1.00 83.68 ? 295 ALA A CB  1 
ATOM 1599 N N   . ARG A 1 296 ? 101.468 69.576  77.062  1.00 75.86 ? 296 ARG A N   1 
ATOM 1600 C CA  . ARG A 1 296 ? 102.728 69.588  76.302  1.00 71.85 ? 296 ARG A CA  1 
ATOM 1601 C C   . ARG A 1 296 ? 102.541 70.023  74.851  1.00 70.00 ? 296 ARG A C   1 
ATOM 1602 O O   . ARG A 1 296 ? 103.462 70.594  74.272  1.00 64.72 ? 296 ARG A O   1 
ATOM 1603 C CB  . ARG A 1 296 ? 103.356 68.194  76.316  1.00 68.20 ? 296 ARG A CB  1 
ATOM 1604 C CG  . ARG A 1 296 ? 103.968 67.830  77.672  1.00 61.30 ? 296 ARG A CG  1 
ATOM 1605 C CD  . ARG A 1 296 ? 104.460 66.388  77.592  1.00 57.93 ? 296 ARG A CD  1 
ATOM 1606 N NE  . ARG A 1 296 ? 105.031 65.925  78.871  1.00 51.38 ? 296 ARG A NE  1 
ATOM 1607 C CZ  . ARG A 1 296 ? 105.620 64.763  79.062  1.00 45.88 ? 296 ARG A CZ  1 
ATOM 1608 N NH1 . ARG A 1 296 ? 105.754 63.896  78.103  1.00 42.86 ? 296 ARG A NH1 1 
ATOM 1609 N NH2 . ARG A 1 296 ? 106.082 64.460  80.234  1.00 40.60 ? 296 ARG A NH2 1 
ATOM 1610 N N   . ASN A 1 297 ? 101.391 69.733  74.264  1.00 70.07 ? 297 ASN A N   1 
ATOM 1611 C CA  . ASN A 1 297 ? 101.089 70.071  72.873  1.00 66.42 ? 297 ASN A CA  1 
ATOM 1612 C C   . ASN A 1 297 ? 100.507 71.482  72.712  1.00 65.60 ? 297 ASN A C   1 
ATOM 1613 O O   . ASN A 1 297 ? 100.274 71.936  71.597  1.00 61.02 ? 297 ASN A O   1 
ATOM 1614 C CB  . ASN A 1 297 ? 100.169 68.992  72.276  1.00 62.11 ? 297 ASN A CB  1 
ATOM 1615 C CG  . ASN A 1 297 ? 100.603 68.566  70.891  1.00 56.09 ? 297 ASN A CG  1 
ATOM 1616 O OD1 . ASN A 1 297 ? 101.674 68.873  70.401  1.00 51.07 ? 297 ASN A OD1 1 
ATOM 1617 N ND2 . ASN A 1 297 ? 99.784  67.779  70.223  1.00 50.26 ? 297 ASN A ND2 1 
ATOM 1618 N N   . TRP A 1 298 ? 100.266 72.150  73.836  1.00 68.47 ? 298 TRP A N   1 
ATOM 1619 C CA  . TRP A 1 298 ? 99.702  73.491  73.876  1.00 65.68 ? 298 TRP A CA  1 
ATOM 1620 C C   . TRP A 1 298 ? 100.804 74.549  73.727  1.00 64.00 ? 298 TRP A C   1 
ATOM 1621 O O   . TRP A 1 298 ? 101.100 75.318  74.634  1.00 59.35 ? 298 TRP A O   1 
ATOM 1622 C CB  . TRP A 1 298 ? 98.837  73.628  75.134  1.00 63.12 ? 298 TRP A CB  1 
ATOM 1623 C CG  . TRP A 1 298 ? 97.841  74.736  75.082  1.00 63.05 ? 298 TRP A CG  1 
ATOM 1624 C CD1 . TRP A 1 298 ? 96.756  74.797  74.284  1.00 55.94 ? 298 TRP A CD1 1 
ATOM 1625 C CD2 . TRP A 1 298 ? 97.812  75.947  75.894  1.00 59.61 ? 298 TRP A CD2 1 
ATOM 1626 N NE1 . TRP A 1 298 ? 96.048  75.967  74.542  1.00 55.12 ? 298 TRP A NE1 1 
ATOM 1627 C CE2 . TRP A 1 298 ? 96.665  76.696  75.520  1.00 58.98 ? 298 TRP A CE2 1 
ATOM 1628 C CE3 . TRP A 1 298 ? 98.636  76.460  76.910  1.00 58.38 ? 298 TRP A CE3 1 
ATOM 1629 C CZ2 . TRP A 1 298 ? 96.353  77.932  76.119  1.00 56.89 ? 298 TRP A CZ2 1 
ATOM 1630 C CZ3 . TRP A 1 298 ? 98.325  77.688  77.512  1.00 51.83 ? 298 TRP A CZ3 1 
ATOM 1631 C CH2 . TRP A 1 298 ? 97.201  78.412  77.111  1.00 52.23 ? 298 TRP A CH2 1 
ATOM 1632 N N   . ASN A 1 299 ? 101.438 74.541  72.549  1.00 60.57 ? 299 ASN A N   1 
ATOM 1633 C CA  . ASN A 1 299 ? 102.291 75.636  72.118  1.00 57.51 ? 299 ASN A CA  1 
ATOM 1634 C C   . ASN A 1 299 ? 101.392 76.737  71.545  1.00 57.50 ? 299 ASN A C   1 
ATOM 1635 O O   . ASN A 1 299 ? 100.920 76.627  70.406  1.00 51.56 ? 299 ASN A O   1 
ATOM 1636 C CB  . ASN A 1 299 ? 103.341 75.139  71.111  1.00 50.17 ? 299 ASN A CB  1 
ATOM 1637 C CG  . ASN A 1 299 ? 104.463 74.334  71.747  1.00 43.98 ? 299 ASN A CG  1 
ATOM 1638 O OD1 . ASN A 1 299 ? 104.711 74.346  72.934  1.00 40.03 ? 299 ASN A OD1 1 
ATOM 1639 N ND2 . ASN A 1 299 ? 105.226 73.626  70.935  1.00 38.21 ? 299 ASN A ND2 1 
ATOM 1640 N N   . PHE A 1 300 ? 101.123 77.751  72.353  1.00 55.59 ? 300 PHE A N   1 
ATOM 1641 C CA  . PHE A 1 300 ? 100.633 79.039  71.905  1.00 51.60 ? 300 PHE A CA  1 
ATOM 1642 C C   . PHE A 1 300 ? 101.812 79.934  71.516  1.00 47.78 ? 300 PHE A C   1 
ATOM 1643 O O   . PHE A 1 300 ? 102.862 79.867  72.187  1.00 42.76 ? 300 PHE A O   1 
ATOM 1644 C CB  . PHE A 1 300 ? 99.729  79.683  72.959  1.00 47.77 ? 300 PHE A CB  1 
ATOM 1645 C CG  . PHE A 1 300 ? 98.325  79.126  72.958  1.00 44.95 ? 300 PHE A CG  1 
ATOM 1646 C CD1 . PHE A 1 300 ? 97.412  79.537  71.975  1.00 42.57 ? 300 PHE A CD1 1 
ATOM 1647 C CD2 . PHE A 1 300 ? 97.912  78.209  73.931  1.00 41.02 ? 300 PHE A CD2 1 
ATOM 1648 C CE1 . PHE A 1 300 ? 96.098  79.040  71.972  1.00 38.45 ? 300 PHE A CE1 1 
ATOM 1649 C CE2 . PHE A 1 300 ? 96.598  77.706  73.925  1.00 40.89 ? 300 PHE A CE2 1 
ATOM 1650 C CZ  . PHE A 1 300 ? 95.686  78.120  72.944  1.00 37.74 ? 300 PHE A CZ  1 
ATOM 1651 N N   . GLY B 1 95  ? 81.009  108.606 85.413  1.00 89.53 ? 95  GLY B N   1 
ATOM 1652 C CA  . GLY B 1 95  ? 81.511  107.819 86.523  1.00 90.04 ? 95  GLY B CA  1 
ATOM 1653 C C   . GLY B 1 95  ? 81.125  106.344 86.462  1.00 91.90 ? 95  GLY B C   1 
ATOM 1654 O O   . GLY B 1 95  ? 80.515  105.860 85.514  1.00 90.19 ? 95  GLY B O   1 
ATOM 1655 N N   . LYS B 1 96  ? 81.524  105.612 87.507  1.00 92.45 ? 96  LYS B N   1 
ATOM 1656 C CA  . LYS B 1 96  ? 81.390  104.162 87.588  1.00 93.37 ? 96  LYS B CA  1 
ATOM 1657 C C   . LYS B 1 96  ? 80.022  103.746 88.135  1.00 93.59 ? 96  LYS B C   1 
ATOM 1658 O O   . LYS B 1 96  ? 79.608  104.223 89.194  1.00 91.71 ? 96  LYS B O   1 
ATOM 1659 C CB  . LYS B 1 96  ? 82.562  103.613 88.426  1.00 91.55 ? 96  LYS B CB  1 
ATOM 1660 C CG  . LYS B 1 96  ? 82.612  102.082 88.507  1.00 88.73 ? 96  LYS B CG  1 
ATOM 1661 C CD  . LYS B 1 96  ? 83.910  101.632 89.194  1.00 86.41 ? 96  LYS B CD  1 
ATOM 1662 C CE  . LYS B 1 96  ? 84.032  100.106 89.203  1.00 79.53 ? 96  LYS B CE  1 
ATOM 1663 N NZ  . LYS B 1 96  ? 85.378  99.633  89.647  1.00 74.41 ? 96  LYS B NZ  1 
ATOM 1664 N N   . LEU B 1 97  ? 79.378  102.812 87.437  1.00 93.99 ? 97  LEU B N   1 
ATOM 1665 C CA  . LEU B 1 97  ? 78.207  102.087 87.928  1.00 94.85 ? 97  LEU B CA  1 
ATOM 1666 C C   . LEU B 1 97  ? 78.584  100.613 88.118  1.00 95.50 ? 97  LEU B C   1 
ATOM 1667 O O   . LEU B 1 97  ? 79.082  99.972  87.201  1.00 95.15 ? 97  LEU B O   1 
ATOM 1668 C CB  . LEU B 1 97  ? 77.058  102.260 86.926  1.00 94.77 ? 97  LEU B CB  1 
ATOM 1669 C CG  . LEU B 1 97  ? 75.726  101.649 87.415  1.00 94.47 ? 97  LEU B CG  1 
ATOM 1670 C CD1 . LEU B 1 97  ? 75.103  102.481 88.532  1.00 90.90 ? 97  LEU B CD1 1 
ATOM 1671 C CD2 . LEU B 1 97  ? 74.731  101.593 86.261  1.00 90.24 ? 97  LEU B CD2 1 
ATOM 1672 N N   . ARG B 1 98  ? 78.328  100.081 89.302  1.00 95.27 ? 98  ARG B N   1 
ATOM 1673 C CA  . ARG B 1 98  ? 78.547  98.663  89.616  1.00 94.96 ? 98  ARG B CA  1 
ATOM 1674 C C   . ARG B 1 98  ? 77.240  97.895  89.420  1.00 95.06 ? 98  ARG B C   1 
ATOM 1675 O O   . ARG B 1 98  ? 76.226  98.245  90.021  1.00 94.01 ? 98  ARG B O   1 
ATOM 1676 C CB  . ARG B 1 98  ? 79.064  98.513  91.050  1.00 93.34 ? 98  ARG B CB  1 
ATOM 1677 C CG  . ARG B 1 98  ? 80.417  99.219  91.283  1.00 89.43 ? 98  ARG B CG  1 
ATOM 1678 C CD  . ARG B 1 98  ? 80.781  99.218  92.762  1.00 86.89 ? 98  ARG B CD  1 
ATOM 1679 N NE  . ARG B 1 98  ? 79.818  100.019 93.536  1.00 79.98 ? 98  ARG B NE  1 
ATOM 1680 C CZ  . ARG B 1 98  ? 79.597  99.964  94.842  1.00 76.39 ? 98  ARG B CZ  1 
ATOM 1681 N NH1 . ARG B 1 98  ? 80.319  99.226  95.645  1.00 68.31 ? 98  ARG B NH1 1 
ATOM 1682 N NH2 . ARG B 1 98  ? 78.627  100.653 95.341  1.00 68.75 ? 98  ARG B NH2 1 
ATOM 1683 N N   . VAL B 1 99  ? 77.273  96.865  88.614  1.00 95.73 ? 99  VAL B N   1 
ATOM 1684 C CA  . VAL B 1 99  ? 76.118  96.027  88.292  1.00 96.16 ? 99  VAL B CA  1 
ATOM 1685 C C   . VAL B 1 99  ? 76.447  94.583  88.651  1.00 96.24 ? 99  VAL B C   1 
ATOM 1686 O O   . VAL B 1 99  ? 77.438  94.051  88.154  1.00 95.54 ? 99  VAL B O   1 
ATOM 1687 C CB  . VAL B 1 99  ? 75.739  96.129  86.804  1.00 95.97 ? 99  VAL B CB  1 
ATOM 1688 C CG1 . VAL B 1 99  ? 74.439  95.385  86.517  1.00 93.23 ? 99  VAL B CG1 1 
ATOM 1689 C CG2 . VAL B 1 99  ? 75.582  97.586  86.340  1.00 92.27 ? 99  VAL B CG2 1 
ATOM 1690 N N   . THR B 1 100 ? 75.633  93.944  89.474  1.00 95.55 ? 100 THR B N   1 
ATOM 1691 C CA  . THR B 1 100 ? 75.801  92.528  89.795  1.00 95.21 ? 100 THR B CA  1 
ATOM 1692 C C   . THR B 1 100 ? 74.711  91.677  89.138  1.00 95.36 ? 100 THR B C   1 
ATOM 1693 O O   . THR B 1 100 ? 73.571  92.103  88.978  1.00 94.92 ? 100 THR B O   1 
ATOM 1694 C CB  . THR B 1 100 ? 75.921  92.287  91.313  1.00 94.23 ? 100 THR B CB  1 
ATOM 1695 O OG1 . THR B 1 100 ? 76.272  90.938  91.553  1.00 89.15 ? 100 THR B OG1 1 
ATOM 1696 C CG2 . THR B 1 100 ? 74.638  92.558  92.091  1.00 88.93 ? 100 THR B CG2 1 
ATOM 1697 N N   . THR B 1 101 ? 75.076  90.461  88.731  1.00 95.35 ? 101 THR B N   1 
ATOM 1698 C CA  . THR B 1 101 ? 74.125  89.443  88.262  1.00 95.57 ? 101 THR B CA  1 
ATOM 1699 C C   . THR B 1 101 ? 74.772  88.061  88.354  1.00 95.10 ? 101 THR B C   1 
ATOM 1700 O O   . THR B 1 101 ? 75.944  87.942  88.729  1.00 93.97 ? 101 THR B O   1 
ATOM 1701 C CB  . THR B 1 101 ? 73.632  89.758  86.836  1.00 95.33 ? 101 THR B CB  1 
ATOM 1702 O OG1 . THR B 1 101 ? 72.523  88.935  86.519  1.00 89.67 ? 101 THR B OG1 1 
ATOM 1703 C CG2 . THR B 1 101 ? 74.691  89.561  85.755  1.00 89.08 ? 101 THR B CG2 1 
ATOM 1704 N N   . THR B 1 102 ? 74.033  87.027  88.000  1.00 94.64 ? 102 THR B N   1 
ATOM 1705 C CA  . THR B 1 102 ? 74.584  85.668  87.907  1.00 94.35 ? 102 THR B CA  1 
ATOM 1706 C C   . THR B 1 102 ? 75.654  85.576  86.814  1.00 94.73 ? 102 THR B C   1 
ATOM 1707 O O   . THR B 1 102 ? 75.628  86.314  85.825  1.00 93.99 ? 102 THR B O   1 
ATOM 1708 C CB  . THR B 1 102 ? 73.488  84.636  87.633  1.00 93.34 ? 102 THR B CB  1 
ATOM 1709 O OG1 . THR B 1 102 ? 72.932  84.825  86.353  1.00 86.85 ? 102 THR B OG1 1 
ATOM 1710 C CG2 . THR B 1 102 ? 72.360  84.725  88.656  1.00 86.30 ? 102 THR B CG2 1 
ATOM 1711 N N   . VAL B 1 103 ? 76.552  84.612  86.945  1.00 94.24 ? 103 VAL B N   1 
ATOM 1712 C CA  . VAL B 1 103 ? 77.613  84.359  85.949  1.00 94.59 ? 103 VAL B CA  1 
ATOM 1713 C C   . VAL B 1 103 ? 77.014  84.056  84.572  1.00 94.88 ? 103 VAL B C   1 
ATOM 1714 O O   . VAL B 1 103 ? 77.441  84.635  83.578  1.00 93.58 ? 103 VAL B O   1 
ATOM 1715 C CB  . VAL B 1 103 ? 78.531  83.213  86.421  1.00 93.85 ? 103 VAL B CB  1 
ATOM 1716 C CG1 . VAL B 1 103 ? 79.640  82.923  85.397  1.00 91.11 ? 103 VAL B CG1 1 
ATOM 1717 C CG2 . VAL B 1 103 ? 79.202  83.545  87.760  1.00 91.16 ? 103 VAL B CG2 1 
ATOM 1718 N N   . GLY B 1 104 ? 75.984  83.219  84.497  1.00 93.80 ? 104 GLY B N   1 
ATOM 1719 C CA  . GLY B 1 104 ? 75.342  82.843  83.237  1.00 93.55 ? 104 GLY B CA  1 
ATOM 1720 C C   . GLY B 1 104 ? 74.714  84.027  82.493  1.00 94.29 ? 104 GLY B C   1 
ATOM 1721 O O   . GLY B 1 104 ? 75.004  84.242  81.318  1.00 93.47 ? 104 GLY B O   1 
ATOM 1722 N N   . LEU B 1 105 ? 73.910  84.830  83.180  1.00 94.68 ? 105 LEU B N   1 
ATOM 1723 C CA  . LEU B 1 105 ? 73.282  86.002  82.573  1.00 94.89 ? 105 LEU B CA  1 
ATOM 1724 C C   . LEU B 1 105 ? 74.327  87.069  82.194  1.00 94.76 ? 105 LEU B C   1 
ATOM 1725 O O   . LEU B 1 105 ? 74.210  87.702  81.144  1.00 93.87 ? 105 LEU B O   1 
ATOM 1726 C CB  . LEU B 1 105 ? 72.217  86.568  83.533  1.00 94.44 ? 105 LEU B CB  1 
ATOM 1727 C CG  . LEU B 1 105 ? 71.357  87.680  82.881  1.00 92.93 ? 105 LEU B CG  1 
ATOM 1728 C CD1 . LEU B 1 105 ? 70.392  87.118  81.826  1.00 85.69 ? 105 LEU B CD1 1 
ATOM 1729 C CD2 . LEU B 1 105 ? 70.514  88.381  83.935  1.00 85.05 ? 105 LEU B CD2 1 
ATOM 1730 N N   . GLY B 1 106 ? 75.341  87.250  83.034  1.00 95.43 ? 106 GLY B N   1 
ATOM 1731 C CA  . GLY B 1 106 ? 76.424  88.185  82.772  1.00 95.64 ? 106 GLY B CA  1 
ATOM 1732 C C   . GLY B 1 106 ? 77.226  87.832  81.524  1.00 96.06 ? 106 GLY B C   1 
ATOM 1733 O O   . GLY B 1 106 ? 77.438  88.684  80.659  1.00 95.28 ? 106 GLY B O   1 
ATOM 1734 N N   . GLN B 1 107 ? 77.607  86.574  81.390  1.00 95.00 ? 107 GLN B N   1 
ATOM 1735 C CA  . GLN B 1 107 ? 78.379  86.075  80.252  1.00 94.60 ? 107 GLN B CA  1 
ATOM 1736 C C   . GLN B 1 107 ? 77.533  85.928  78.980  1.00 94.17 ? 107 GLN B C   1 
ATOM 1737 O O   . GLN B 1 107 ? 78.006  86.250  77.892  1.00 92.67 ? 107 GLN B O   1 
ATOM 1738 C CB  . GLN B 1 107 ? 79.025  84.734  80.626  1.00 94.35 ? 107 GLN B CB  1 
ATOM 1739 C CG  . GLN B 1 107 ? 80.122  84.903  81.684  1.00 93.55 ? 107 GLN B CG  1 
ATOM 1740 C CD  . GLN B 1 107 ? 80.807  83.583  82.042  1.00 93.60 ? 107 GLN B CD  1 
ATOM 1741 O OE1 . GLN B 1 107 ? 80.347  82.488  81.771  1.00 86.64 ? 107 GLN B OE1 1 
ATOM 1742 N NE2 . GLN B 1 107 ? 81.966  83.647  82.660  1.00 86.11 ? 107 GLN B NE2 1 
ATOM 1743 N N   . GLY B 1 108 ? 76.297  85.444  79.104  1.00 93.67 ? 108 GLY B N   1 
ATOM 1744 C CA  . GLY B 1 108 ? 75.449  85.106  77.963  1.00 92.73 ? 108 GLY B CA  1 
ATOM 1745 C C   . GLY B 1 108 ? 74.712  86.288  77.328  1.00 92.96 ? 108 GLY B C   1 
ATOM 1746 O O   . GLY B 1 108 ? 74.460  86.269  76.123  1.00 90.44 ? 108 GLY B O   1 
ATOM 1747 N N   . TRP B 1 109 ? 74.360  87.294  78.115  1.00 94.64 ? 109 TRP B N   1 
ATOM 1748 C CA  . TRP B 1 109 ? 73.506  88.405  77.663  1.00 94.48 ? 109 TRP B CA  1 
ATOM 1749 C C   . TRP B 1 109 ? 74.034  89.796  78.020  1.00 94.51 ? 109 TRP B C   1 
ATOM 1750 O O   . TRP B 1 109 ? 74.111  90.670  77.153  1.00 93.29 ? 109 TRP B O   1 
ATOM 1751 C CB  . TRP B 1 109 ? 72.099  88.190  78.226  1.00 93.55 ? 109 TRP B CB  1 
ATOM 1752 C CG  . TRP B 1 109 ? 71.062  89.157  77.743  1.00 92.84 ? 109 TRP B CG  1 
ATOM 1753 C CD1 . TRP B 1 109 ? 70.407  89.088  76.569  1.00 89.69 ? 109 TRP B CD1 1 
ATOM 1754 C CD2 . TRP B 1 109 ? 70.545  90.347  78.436  1.00 91.60 ? 109 TRP B CD2 1 
ATOM 1755 N NE1 . TRP B 1 109 ? 69.504  90.142  76.478  1.00 88.68 ? 109 TRP B NE1 1 
ATOM 1756 C CE2 . TRP B 1 109 ? 69.555  90.930  77.601  1.00 90.18 ? 109 TRP B CE2 1 
ATOM 1757 C CE3 . TRP B 1 109 ? 70.819  90.966  79.675  1.00 89.34 ? 109 TRP B CE3 1 
ATOM 1758 C CZ2 . TRP B 1 109 ? 68.834  92.093  77.989  1.00 88.53 ? 109 TRP B CZ2 1 
ATOM 1759 C CZ3 . TRP B 1 109 ? 70.104  92.129  80.055  1.00 87.35 ? 109 TRP B CZ3 1 
ATOM 1760 C CH2 . TRP B 1 109 ? 69.127  92.677  79.218  1.00 87.49 ? 109 TRP B CH2 1 
ATOM 1761 N N   . LEU B 1 110 ? 74.397  90.020  79.284  1.00 95.36 ? 110 LEU B N   1 
ATOM 1762 C CA  . LEU B 1 110 ? 74.659  91.364  79.794  1.00 96.03 ? 110 LEU B CA  1 
ATOM 1763 C C   . LEU B 1 110 ? 75.928  91.999  79.217  1.00 96.37 ? 110 LEU B C   1 
ATOM 1764 O O   . LEU B 1 110 ? 75.925  93.197  78.968  1.00 95.72 ? 110 LEU B O   1 
ATOM 1765 C CB  . LEU B 1 110 ? 74.673  91.322  81.329  1.00 95.96 ? 110 LEU B CB  1 
ATOM 1766 C CG  . LEU B 1 110 ? 74.791  92.697  82.007  1.00 95.46 ? 110 LEU B CG  1 
ATOM 1767 C CD1 . LEU B 1 110 ? 73.655  93.653  81.636  1.00 91.76 ? 110 LEU B CD1 1 
ATOM 1768 C CD2 . LEU B 1 110 ? 74.765  92.514  83.531  1.00 91.29 ? 110 LEU B CD2 1 
ATOM 1769 N N   . THR B 1 111 ? 76.986  91.226  78.955  1.00 95.53 ? 111 THR B N   1 
ATOM 1770 C CA  . THR B 1 111 ? 78.231  91.743  78.365  1.00 95.53 ? 111 THR B CA  1 
ATOM 1771 C C   . THR B 1 111 ? 77.965  92.438  77.029  1.00 95.12 ? 111 THR B C   1 
ATOM 1772 O O   . THR B 1 111 ? 78.377  93.578  76.844  1.00 94.33 ? 111 THR B O   1 
ATOM 1773 C CB  . THR B 1 111 ? 79.269  90.627  78.193  1.00 95.00 ? 111 THR B CB  1 
ATOM 1774 O OG1 . THR B 1 111 ? 79.563  90.059  79.448  1.00 87.87 ? 111 THR B OG1 1 
ATOM 1775 C CG2 . THR B 1 111 ? 80.593  91.138  77.621  1.00 87.41 ? 111 THR B CG2 1 
ATOM 1776 N N   . ASP B 1 112 ? 77.204  91.810  76.141  1.00 94.20 ? 112 ASP B N   1 
ATOM 1777 C CA  . ASP B 1 112 ? 76.837  92.389  74.843  1.00 92.80 ? 112 ASP B CA  1 
ATOM 1778 C C   . ASP B 1 112 ? 75.942  93.630  75.009  1.00 92.60 ? 112 ASP B C   1 
ATOM 1779 O O   . ASP B 1 112 ? 76.097  94.619  74.296  1.00 90.66 ? 112 ASP B O   1 
ATOM 1780 C CB  . ASP B 1 112 ? 76.135  91.318  73.986  1.00 91.06 ? 112 ASP B CB  1 
ATOM 1781 C CG  . ASP B 1 112 ? 77.090  90.257  73.411  1.00 87.89 ? 112 ASP B CG  1 
ATOM 1782 O OD1 . ASP B 1 112 ? 78.034  89.818  74.099  1.00 81.27 ? 112 ASP B OD1 1 
ATOM 1783 O OD2 . ASP B 1 112 ? 76.894  89.852  72.241  1.00 80.74 ? 112 ASP B OD2 1 
ATOM 1784 N N   . LYS B 1 113 ? 75.050  93.639  75.997  1.00 93.37 ? 113 LYS B N   1 
ATOM 1785 C CA  . LYS B 1 113 ? 74.230  94.815  76.301  1.00 92.68 ? 113 LYS B CA  1 
ATOM 1786 C C   . LYS B 1 113 ? 75.050  95.976  76.859  1.00 93.06 ? 113 LYS B C   1 
ATOM 1787 O O   . LYS B 1 113 ? 74.761  97.126  76.538  1.00 92.22 ? 113 LYS B O   1 
ATOM 1788 C CB  . LYS B 1 113 ? 73.074  94.447  77.242  1.00 91.71 ? 113 LYS B CB  1 
ATOM 1789 C CG  . LYS B 1 113 ? 72.097  93.417  76.665  1.00 89.56 ? 113 LYS B CG  1 
ATOM 1790 C CD  . LYS B 1 113 ? 71.348  93.923  75.430  1.00 86.17 ? 113 LYS B CD  1 
ATOM 1791 C CE  . LYS B 1 113 ? 70.991  92.776  74.480  1.00 83.44 ? 113 LYS B CE  1 
ATOM 1792 N NZ  . LYS B 1 113 ? 71.770  92.870  73.222  1.00 76.65 ? 113 LYS B NZ  1 
ATOM 1793 N N   . VAL B 1 114 ? 76.069  95.686  77.648  1.00 94.80 ? 114 VAL B N   1 
ATOM 1794 C CA  . VAL B 1 114 ? 76.981  96.703  78.186  1.00 95.53 ? 114 VAL B CA  1 
ATOM 1795 C C   . VAL B 1 114 ? 77.808  97.351  77.074  1.00 95.23 ? 114 VAL B C   1 
ATOM 1796 O O   . VAL B 1 114 ? 78.040  98.552  77.131  1.00 94.37 ? 114 VAL B O   1 
ATOM 1797 C CB  . VAL B 1 114 ? 77.874  96.109  79.290  1.00 95.39 ? 114 VAL B CB  1 
ATOM 1798 C CG1 . VAL B 1 114 ? 79.039  97.032  79.691  1.00 89.90 ? 114 VAL B CG1 1 
ATOM 1799 C CG2 . VAL B 1 114 ? 77.034  95.870  80.550  1.00 89.64 ? 114 VAL B CG2 1 
ATOM 1800 N N   . GLN B 1 115 ? 78.189  96.605  76.031  1.00 94.28 ? 115 GLN B N   1 
ATOM 1801 C CA  . GLN B 1 115 ? 78.819  97.203  74.843  1.00 92.52 ? 115 GLN B CA  1 
ATOM 1802 C C   . GLN B 1 115 ? 77.912  98.252  74.204  1.00 91.48 ? 115 GLN B C   1 
ATOM 1803 O O   . GLN B 1 115 ? 78.338  99.387  73.992  1.00 90.00 ? 115 GLN B O   1 
ATOM 1804 C CB  . GLN B 1 115 ? 79.161  96.106  73.836  1.00 91.41 ? 115 GLN B CB  1 
ATOM 1805 C CG  . GLN B 1 115 ? 79.876  96.640  72.578  1.00 85.37 ? 115 GLN B CG  1 
ATOM 1806 C CD  . GLN B 1 115 ? 79.225  96.234  71.264  1.00 79.47 ? 115 GLN B CD  1 
ATOM 1807 O OE1 . GLN B 1 115 ? 78.153  95.668  71.192  1.00 71.27 ? 115 GLN B OE1 1 
ATOM 1808 N NE2 . GLN B 1 115 ? 79.861  96.534  70.154  1.00 68.52 ? 115 GLN B NE2 1 
ATOM 1809 N N   . GLU B 1 116 ? 76.652  97.901  73.948  1.00 89.29 ? 116 GLU B N   1 
ATOM 1810 C CA  . GLU B 1 116 ? 75.662  98.825  73.408  1.00 85.86 ? 116 GLU B CA  1 
ATOM 1811 C C   . GLU B 1 116 ? 75.481  100.044 74.335  1.00 85.47 ? 116 GLU B C   1 
ATOM 1812 O O   . GLU B 1 116 ? 75.418  101.169 73.857  1.00 83.93 ? 116 GLU B O   1 
ATOM 1813 C CB  . GLU B 1 116 ? 74.320  98.104  73.203  1.00 83.56 ? 116 GLU B CB  1 
ATOM 1814 C CG  . GLU B 1 116 ? 74.321  96.991  72.134  1.00 78.47 ? 116 GLU B CG  1 
ATOM 1815 C CD  . GLU B 1 116 ? 72.978  96.218  72.116  1.00 76.22 ? 116 GLU B CD  1 
ATOM 1816 O OE1 . GLU B 1 116 ? 72.963  94.980  72.037  1.00 69.45 ? 116 GLU B OE1 1 
ATOM 1817 O OE2 . GLU B 1 116 ? 71.905  96.851  72.216  1.00 69.79 ? 116 GLU B OE2 1 
ATOM 1818 N N   . PHE B 1 117 ? 75.432  99.840  75.661  1.00 88.99 ? 117 PHE B N   1 
ATOM 1819 C CA  . PHE B 1 117 ? 75.278  100.908 76.639  1.00 89.35 ? 117 PHE B CA  1 
ATOM 1820 C C   . PHE B 1 117 ? 76.461  101.884 76.646  1.00 88.31 ? 117 PHE B C   1 
ATOM 1821 O O   . PHE B 1 117 ? 76.258  103.096 76.590  1.00 87.64 ? 117 PHE B O   1 
ATOM 1822 C CB  . PHE B 1 117 ? 75.068  100.296 78.027  1.00 90.24 ? 117 PHE B CB  1 
ATOM 1823 C CG  . PHE B 1 117 ? 74.903  101.331 79.113  1.00 90.98 ? 117 PHE B CG  1 
ATOM 1824 C CD1 . PHE B 1 117 ? 75.982  101.655 79.953  1.00 87.93 ? 117 PHE B CD1 1 
ATOM 1825 C CD2 . PHE B 1 117 ? 73.681  102.003 79.256  1.00 87.94 ? 117 PHE B CD2 1 
ATOM 1826 C CE1 . PHE B 1 117 ? 75.838  102.656 80.937  1.00 88.10 ? 117 PHE B CE1 1 
ATOM 1827 C CE2 . PHE B 1 117 ? 73.528  103.000 80.236  1.00 87.97 ? 117 PHE B CE2 1 
ATOM 1828 C CZ  . PHE B 1 117 ? 74.611  103.331 81.073  1.00 91.10 ? 117 PHE B CZ  1 
ATOM 1829 N N   . LEU B 1 118 ? 77.686  101.368 76.681  1.00 90.56 ? 118 LEU B N   1 
ATOM 1830 C CA  . LEU B 1 118 ? 78.903  102.190 76.725  1.00 90.80 ? 118 LEU B CA  1 
ATOM 1831 C C   . LEU B 1 118 ? 79.150  102.965 75.421  1.00 89.44 ? 118 LEU B C   1 
ATOM 1832 O O   . LEU B 1 118 ? 79.831  103.991 75.444  1.00 87.85 ? 118 LEU B O   1 
ATOM 1833 C CB  . LEU B 1 118 ? 80.106  101.302 77.068  1.00 91.85 ? 118 LEU B CB  1 
ATOM 1834 C CG  . LEU B 1 118 ? 80.145  100.798 78.520  1.00 92.40 ? 118 LEU B CG  1 
ATOM 1835 C CD1 . LEU B 1 118 ? 81.321  99.837  78.683  1.00 88.85 ? 118 LEU B CD1 1 
ATOM 1836 C CD2 . LEU B 1 118 ? 80.316  101.937 79.530  1.00 88.85 ? 118 LEU B CD2 1 
ATOM 1837 N N   . GLN B 1 119 ? 78.588  102.520 74.286  1.00 86.28 ? 119 GLN B N   1 
ATOM 1838 C CA  . GLN B 1 119 ? 78.588  103.323 73.056  1.00 82.90 ? 119 GLN B CA  1 
ATOM 1839 C C   . GLN B 1 119 ? 77.695  104.566 73.185  1.00 81.77 ? 119 GLN B C   1 
ATOM 1840 O O   . GLN B 1 119 ? 77.986  105.590 72.580  1.00 79.18 ? 119 GLN B O   1 
ATOM 1841 C CB  . GLN B 1 119 ? 78.128  102.472 71.865  1.00 80.42 ? 119 GLN B CB  1 
ATOM 1842 C CG  . GLN B 1 119 ? 79.215  101.487 71.392  1.00 73.13 ? 119 GLN B CG  1 
ATOM 1843 C CD  . GLN B 1 119 ? 78.813  100.712 70.134  1.00 68.40 ? 119 GLN B CD  1 
ATOM 1844 O OE1 . GLN B 1 119 ? 77.690  100.756 69.657  1.00 61.03 ? 119 GLN B OE1 1 
ATOM 1845 N NE2 . GLN B 1 119 ? 79.724  100.000 69.533  1.00 58.32 ? 119 GLN B NE2 1 
ATOM 1846 N N   . LEU B 1 120 ? 76.629  104.481 73.985  1.00 82.37 ? 120 LEU B N   1 
ATOM 1847 C CA  . LEU B 1 120 ? 75.677  105.572 74.192  1.00 79.85 ? 120 LEU B CA  1 
ATOM 1848 C C   . LEU B 1 120 ? 76.139  106.551 75.284  1.00 79.82 ? 120 LEU B C   1 
ATOM 1849 O O   . LEU B 1 120 ? 75.926  107.745 75.166  1.00 78.34 ? 120 LEU B O   1 
ATOM 1850 C CB  . LEU B 1 120 ? 74.320  104.973 74.549  1.00 77.77 ? 120 LEU B CB  1 
ATOM 1851 C CG  . LEU B 1 120 ? 73.774  104.004 73.478  1.00 73.95 ? 120 LEU B CG  1 
ATOM 1852 C CD1 . LEU B 1 120 ? 72.549  103.262 74.011  1.00 70.58 ? 120 LEU B CD1 1 
ATOM 1853 C CD2 . LEU B 1 120 ? 73.478  104.716 72.161  1.00 69.33 ? 120 LEU B CD2 1 
ATOM 1854 N N   . TYR B 1 121 ? 76.797  106.017 76.317  1.00 84.29 ? 121 TYR B N   1 
ATOM 1855 C CA  . TYR B 1 121 ? 77.265  106.772 77.481  1.00 85.41 ? 121 TYR B CA  1 
ATOM 1856 C C   . TYR B 1 121 ? 78.781  106.606 77.671  1.00 87.00 ? 121 TYR B C   1 
ATOM 1857 O O   . TYR B 1 121 ? 79.230  105.999 78.638  1.00 86.70 ? 121 TYR B O   1 
ATOM 1858 C CB  . TYR B 1 121 ? 76.471  106.342 78.717  1.00 84.57 ? 121 TYR B CB  1 
ATOM 1859 C CG  . TYR B 1 121 ? 74.978  106.471 78.547  1.00 83.47 ? 121 TYR B CG  1 
ATOM 1860 C CD1 . TYR B 1 121 ? 74.344  107.720 78.652  1.00 80.52 ? 121 TYR B CD1 1 
ATOM 1861 C CD2 . TYR B 1 121 ? 74.202  105.334 78.241  1.00 80.45 ? 121 TYR B CD2 1 
ATOM 1862 C CE1 . TYR B 1 121 ? 72.960  107.845 78.463  1.00 78.78 ? 121 TYR B CE1 1 
ATOM 1863 C CE2 . TYR B 1 121 ? 72.813  105.441 78.047  1.00 78.25 ? 121 TYR B CE2 1 
ATOM 1864 C CZ  . TYR B 1 121 ? 72.199  106.699 78.158  1.00 80.16 ? 121 TYR B CZ  1 
ATOM 1865 O OH  . TYR B 1 121 ? 70.862  106.801 77.965  1.00 78.18 ? 121 TYR B OH  1 
ATOM 1866 N N   . PRO B 1 122 ? 79.597  107.156 76.750  1.00 86.16 ? 122 PRO B N   1 
ATOM 1867 C CA  . PRO B 1 122 ? 81.041  106.918 76.744  1.00 86.15 ? 122 PRO B CA  1 
ATOM 1868 C C   . PRO B 1 122 ? 81.777  107.524 77.944  1.00 87.91 ? 122 PRO B C   1 
ATOM 1869 O O   . PRO B 1 122 ? 82.894  107.110 78.235  1.00 86.53 ? 122 PRO B O   1 
ATOM 1870 C CB  . PRO B 1 122 ? 81.526  107.509 75.418  1.00 83.23 ? 122 PRO B CB  1 
ATOM 1871 C CG  . PRO B 1 122 ? 80.507  108.605 75.106  1.00 81.18 ? 122 PRO B CG  1 
ATOM 1872 C CD  . PRO B 1 122 ? 79.207  107.982 75.615  1.00 83.75 ? 122 PRO B CD  1 
ATOM 1873 N N   . GLU B 1 123 ? 81.175  108.485 78.655  1.00 88.28 ? 123 GLU B N   1 
ATOM 1874 C CA  . GLU B 1 123 ? 81.746  109.066 79.881  1.00 88.63 ? 123 GLU B CA  1 
ATOM 1875 C C   . GLU B 1 123 ? 81.420  108.243 81.141  1.00 90.28 ? 123 GLU B C   1 
ATOM 1876 O O   . GLU B 1 123 ? 81.905  108.550 82.234  1.00 88.46 ? 123 GLU B O   1 
ATOM 1877 C CB  . GLU B 1 123 ? 81.314  110.535 80.036  1.00 86.13 ? 123 GLU B CB  1 
ATOM 1878 C CG  . GLU B 1 123 ? 81.781  111.433 78.871  1.00 80.97 ? 123 GLU B CG  1 
ATOM 1879 C CD  . GLU B 1 123 ? 81.673  112.941 79.179  1.00 73.03 ? 123 GLU B CD  1 
ATOM 1880 O OE1 . GLU B 1 123 ? 81.438  113.751 78.232  1.00 64.25 ? 123 GLU B OE1 1 
ATOM 1881 O OE2 . GLU B 1 123 ? 81.849  113.333 80.353  1.00 63.31 ? 123 GLU B OE2 1 
ATOM 1882 N N   . MET B 1 124 ? 80.630  107.186 81.011  1.00 91.40 ? 124 MET B N   1 
ATOM 1883 C CA  . MET B 1 124 ? 80.426  106.210 82.074  1.00 92.97 ? 124 MET B CA  1 
ATOM 1884 C C   . MET B 1 124 ? 81.450  105.077 81.984  1.00 93.83 ? 124 MET B C   1 
ATOM 1885 O O   . MET B 1 124 ? 81.968  104.750 80.924  1.00 93.03 ? 124 MET B O   1 
ATOM 1886 C CB  . MET B 1 124 ? 78.997  105.663 82.060  1.00 92.39 ? 124 MET B CB  1 
ATOM 1887 C CG  . MET B 1 124 ? 77.983  106.717 82.524  1.00 88.98 ? 124 MET B CG  1 
ATOM 1888 S SD  . MET B 1 124 ? 76.293  106.092 82.763  1.00 90.10 ? 124 MET B SD  1 
ATOM 1889 C CE  . MET B 1 124 ? 76.548  104.918 84.118  1.00 83.90 ? 124 MET B CE  1 
ATOM 1890 N N   . SER B 1 125 ? 81.671  104.451 83.120  1.00 94.47 ? 125 SER B N   1 
ATOM 1891 C CA  . SER B 1 125 ? 82.307  103.140 83.199  1.00 95.23 ? 125 SER B CA  1 
ATOM 1892 C C   . SER B 1 125 ? 81.394  102.167 83.938  1.00 95.89 ? 125 SER B C   1 
ATOM 1893 O O   . SER B 1 125 ? 80.589  102.560 84.788  1.00 94.52 ? 125 SER B O   1 
ATOM 1894 C CB  . SER B 1 125 ? 83.696  103.238 83.831  1.00 93.16 ? 125 SER B CB  1 
ATOM 1895 O OG  . SER B 1 125 ? 83.636  103.620 85.191  1.00 83.01 ? 125 SER B OG  1 
ATOM 1896 N N   . ILE B 1 126 ? 81.499  100.889 83.608  1.00 95.65 ? 126 ILE B N   1 
ATOM 1897 C CA  . ILE B 1 126 ? 80.728  99.817  84.235  1.00 96.58 ? 126 ILE B CA  1 
ATOM 1898 C C   . ILE B 1 126 ? 81.677  98.829  84.904  1.00 96.59 ? 126 ILE B C   1 
ATOM 1899 O O   . ILE B 1 126 ? 82.688  98.433  84.333  1.00 96.01 ? 126 ILE B O   1 
ATOM 1900 C CB  . ILE B 1 126 ? 79.803  99.135  83.203  1.00 96.09 ? 126 ILE B CB  1 
ATOM 1901 C CG1 . ILE B 1 126 ? 78.719  100.088 82.647  1.00 92.70 ? 126 ILE B CG1 1 
ATOM 1902 C CG2 . ILE B 1 126 ? 79.130  97.874  83.776  1.00 93.15 ? 126 ILE B CG2 1 
ATOM 1903 C CD1 . ILE B 1 126 ? 77.633  100.532 83.641  1.00 88.10 ? 126 ILE B CD1 1 
ATOM 1904 N N   . GLN B 1 127 ? 81.314  98.400  86.093  1.00 95.59 ? 127 GLN B N   1 
ATOM 1905 C CA  . GLN B 1 127 ? 81.854  97.184  86.687  1.00 95.30 ? 127 GLN B CA  1 
ATOM 1906 C C   . GLN B 1 127 ? 80.749  96.135  86.752  1.00 95.20 ? 127 GLN B C   1 
ATOM 1907 O O   . GLN B 1 127 ? 79.779  96.314  87.499  1.00 94.09 ? 127 GLN B O   1 
ATOM 1908 C CB  . GLN B 1 127 ? 82.456  97.477  88.069  1.00 94.19 ? 127 GLN B CB  1 
ATOM 1909 C CG  . GLN B 1 127 ? 83.016  96.202  88.741  1.00 93.36 ? 127 GLN B CG  1 
ATOM 1910 C CD  . GLN B 1 127 ? 83.714  96.484  90.073  1.00 93.16 ? 127 GLN B CD  1 
ATOM 1911 O OE1 . GLN B 1 127 ? 83.553  97.527  90.693  1.00 87.81 ? 127 GLN B OE1 1 
ATOM 1912 N NE2 . GLN B 1 127 ? 84.510  95.565  90.559  1.00 85.64 ? 127 GLN B NE2 1 
ATOM 1913 N N   . LEU B 1 128 ? 80.909  95.053  86.002  1.00 95.82 ? 128 LEU B N   1 
ATOM 1914 C CA  . LEU B 1 128 ? 80.094  93.863  86.170  1.00 96.04 ? 128 LEU B CA  1 
ATOM 1915 C C   . LEU B 1 128 ? 80.725  92.969  87.233  1.00 95.70 ? 128 LEU B C   1 
ATOM 1916 O O   . LEU B 1 128 ? 81.893  92.598  87.128  1.00 95.17 ? 128 LEU B O   1 
ATOM 1917 C CB  . LEU B 1 128 ? 79.932  93.112  84.837  1.00 95.96 ? 128 LEU B CB  1 
ATOM 1918 C CG  . LEU B 1 128 ? 79.258  93.906  83.709  1.00 94.48 ? 128 LEU B CG  1 
ATOM 1919 C CD1 . LEU B 1 128 ? 79.046  92.996  82.498  1.00 90.15 ? 128 LEU B CD1 1 
ATOM 1920 C CD2 . LEU B 1 128 ? 77.895  94.467  84.120  1.00 90.72 ? 128 LEU B CD2 1 
ATOM 1921 N N   . ILE B 1 129 ? 79.941  92.635  88.246  1.00 95.56 ? 129 ILE B N   1 
ATOM 1922 C CA  . ILE B 1 129 ? 80.314  91.718  89.313  1.00 94.68 ? 129 ILE B CA  1 
ATOM 1923 C C   . ILE B 1 129 ? 79.433  90.483  89.144  1.00 94.25 ? 129 ILE B C   1 
ATOM 1924 O O   . ILE B 1 129 ? 78.248  90.501  89.486  1.00 93.16 ? 129 ILE B O   1 
ATOM 1925 C CB  . ILE B 1 129 ? 80.165  92.380  90.696  1.00 93.90 ? 129 ILE B CB  1 
ATOM 1926 C CG1 . ILE B 1 129 ? 80.924  93.730  90.777  1.00 91.27 ? 129 ILE B CG1 1 
ATOM 1927 C CG2 . ILE B 1 129 ? 80.680  91.413  91.778  1.00 90.24 ? 129 ILE B CG2 1 
ATOM 1928 C CD1 . ILE B 1 129 ? 80.550  94.566  92.014  1.00 85.50 ? 129 ILE B CD1 1 
ATOM 1929 N N   . LEU B 1 130 ? 80.000  89.443  88.530  1.00 94.94 ? 130 LEU B N   1 
ATOM 1930 C CA  . LEU B 1 130 ? 79.294  88.206  88.237  1.00 94.60 ? 130 LEU B CA  1 
ATOM 1931 C C   . LEU B 1 130 ? 79.497  87.233  89.390  1.00 93.61 ? 130 LEU B C   1 
ATOM 1932 O O   . LEU B 1 130 ? 80.635  86.849  89.680  1.00 91.65 ? 130 LEU B O   1 
ATOM 1933 C CB  . LEU B 1 130 ? 79.759  87.620  86.898  1.00 94.57 ? 130 LEU B CB  1 
ATOM 1934 C CG  . LEU B 1 130 ? 79.750  88.593  85.710  1.00 94.62 ? 130 LEU B CG  1 
ATOM 1935 C CD1 . LEU B 1 130 ? 80.066  87.831  84.417  1.00 91.58 ? 130 LEU B CD1 1 
ATOM 1936 C CD2 . LEU B 1 130 ? 78.413  89.296  85.517  1.00 90.95 ? 130 LEU B CD2 1 
ATOM 1937 N N   . ASP B 1 131 ? 78.397  86.849  90.020  1.00 92.65 ? 131 ASP B N   1 
ATOM 1938 C CA  . ASP B 1 131 ? 78.409  85.913  91.136  1.00 91.69 ? 131 ASP B CA  1 
ATOM 1939 C C   . ASP B 1 131 ? 77.118  85.090  91.127  1.00 91.59 ? 131 ASP B C   1 
ATOM 1940 O O   . ASP B 1 131 ? 76.036  85.614  90.834  1.00 89.60 ? 131 ASP B O   1 
ATOM 1941 C CB  . ASP B 1 131 ? 78.603  86.681  92.449  1.00 89.35 ? 131 ASP B CB  1 
ATOM 1942 C CG  . ASP B 1 131 ? 79.148  85.783  93.565  1.00 86.67 ? 131 ASP B CG  1 
ATOM 1943 O OD1 . ASP B 1 131 ? 78.865  84.569  93.510  1.00 80.74 ? 131 ASP B OD1 1 
ATOM 1944 O OD2 . ASP B 1 131 ? 79.865  86.332  94.429  1.00 79.33 ? 131 ASP B OD2 1 
ATOM 1945 N N   . ASN B 1 132 ? 77.233  83.806  91.398  1.00 89.83 ? 132 ASN B N   1 
ATOM 1946 C CA  . ASN B 1 132 ? 76.071  82.942  91.566  1.00 88.72 ? 132 ASN B CA  1 
ATOM 1947 C C   . ASN B 1 132 ? 75.526  83.012  92.996  1.00 87.56 ? 132 ASN B C   1 
ATOM 1948 O O   . ASN B 1 132 ? 74.363  82.669  93.209  1.00 83.55 ? 132 ASN B O   1 
ATOM 1949 C CB  . ASN B 1 132 ? 76.409  81.522  91.115  1.00 87.56 ? 132 ASN B CB  1 
ATOM 1950 C CG  . ASN B 1 132 ? 76.507  81.381  89.601  1.00 87.96 ? 132 ASN B CG  1 
ATOM 1951 O OD1 . ASN B 1 132 ? 75.963  82.149  88.824  1.00 82.44 ? 132 ASN B OD1 1 
ATOM 1952 N ND2 . ASN B 1 132 ? 77.178  80.353  89.148  1.00 81.67 ? 132 ASN B ND2 1 
ATOM 1953 N N   . GLU B 1 133 ? 76.312  83.495  93.956  1.00 86.21 ? 133 GLU B N   1 
ATOM 1954 C CA  . GLU B 1 133 ? 75.769  83.947  95.224  1.00 83.97 ? 133 GLU B CA  1 
ATOM 1955 C C   . GLU B 1 133 ? 75.151  85.341  95.041  1.00 83.59 ? 133 GLU B C   1 
ATOM 1956 O O   . GLU B 1 133 ? 75.669  86.204  94.332  1.00 78.12 ? 133 GLU B O   1 
ATOM 1957 C CB  . GLU B 1 133 ? 76.820  83.900  96.343  1.00 80.28 ? 133 GLU B CB  1 
ATOM 1958 C CG  . GLU B 1 133 ? 77.331  82.463  96.577  1.00 71.83 ? 133 GLU B CG  1 
ATOM 1959 C CD  . GLU B 1 133 ? 78.013  82.251  97.938  1.00 64.64 ? 133 GLU B CD  1 
ATOM 1960 O OE1 . GLU B 1 133 ? 78.150  81.064  98.318  1.00 55.67 ? 133 GLU B OE1 1 
ATOM 1961 O OE2 . GLU B 1 133 ? 78.303  83.240  98.640  1.00 55.88 ? 133 GLU B OE2 1 
ATOM 1962 N N   . GLU B 1 134 ? 73.984  85.557  95.624  1.00 82.63 ? 134 GLU B N   1 
ATOM 1963 C CA  . GLU B 1 134 ? 73.313  86.856  95.507  1.00 82.58 ? 134 GLU B CA  1 
ATOM 1964 C C   . GLU B 1 134 ? 74.017  87.900  96.376  1.00 82.10 ? 134 GLU B C   1 
ATOM 1965 O O   . GLU B 1 134 ? 73.687  88.072  97.551  1.00 77.34 ? 134 GLU B O   1 
ATOM 1966 C CB  . GLU B 1 134 ? 71.817  86.744  95.841  1.00 78.94 ? 134 GLU B CB  1 
ATOM 1967 C CG  . GLU B 1 134 ? 70.961  86.266  94.661  1.00 74.51 ? 134 GLU B CG  1 
ATOM 1968 C CD  . GLU B 1 134 ? 69.459  86.290  94.969  1.00 73.30 ? 134 GLU B CD  1 
ATOM 1969 O OE1 . GLU B 1 134 ? 68.638  86.100  94.044  1.00 66.95 ? 134 GLU B OE1 1 
ATOM 1970 O OE2 . GLU B 1 134 ? 69.059  86.439  96.144  1.00 71.56 ? 134 GLU B OE2 1 
ATOM 1971 N N   . LEU B 1 135 ? 74.938  88.649  95.784  1.00 78.53 ? 135 LEU B N   1 
ATOM 1972 C CA  . LEU B 1 135 ? 75.593  89.775  96.443  1.00 77.53 ? 135 LEU B CA  1 
ATOM 1973 C C   . LEU B 1 135 ? 74.565  90.786  96.952  1.00 78.83 ? 135 LEU B C   1 
ATOM 1974 O O   . LEU B 1 135 ? 73.690  91.243  96.206  1.00 74.41 ? 135 LEU B O   1 
ATOM 1975 C CB  . LEU B 1 135 ? 76.571  90.461  95.480  1.00 73.32 ? 135 LEU B CB  1 
ATOM 1976 C CG  . LEU B 1 135 ? 77.806  89.621  95.116  1.00 69.08 ? 135 LEU B CG  1 
ATOM 1977 C CD1 . LEU B 1 135 ? 78.597  90.357  94.036  1.00 63.93 ? 135 LEU B CD1 1 
ATOM 1978 C CD2 . LEU B 1 135 ? 78.725  89.405  96.312  1.00 63.67 ? 135 LEU B CD2 1 
ATOM 1979 N N   . ASP B 1 136 ? 74.709  91.177  98.217  1.00 78.79 ? 136 ASP B N   1 
ATOM 1980 C CA  . ASP B 1 136 ? 73.808  92.144  98.836  1.00 76.93 ? 136 ASP B CA  1 
ATOM 1981 C C   . ASP B 1 136 ? 74.049  93.555  98.270  1.00 77.85 ? 136 ASP B C   1 
ATOM 1982 O O   . ASP B 1 136 ? 75.072  94.193  98.493  1.00 72.69 ? 136 ASP B O   1 
ATOM 1983 C CB  . ASP B 1 136 ? 73.929  92.083  100.361 1.00 71.48 ? 136 ASP B CB  1 
ATOM 1984 C CG  . ASP B 1 136 ? 72.771  92.814  101.049 1.00 65.40 ? 136 ASP B CG  1 
ATOM 1985 O OD1 . ASP B 1 136 ? 72.176  93.740  100.439 1.00 58.67 ? 136 ASP B OD1 1 
ATOM 1986 O OD2 . ASP B 1 136 ? 72.466  92.453  102.205 1.00 58.94 ? 136 ASP B OD2 1 
ATOM 1987 N N   . VAL B 1 137 ? 73.059  94.044  97.525  1.00 76.50 ? 137 VAL B N   1 
ATOM 1988 C CA  . VAL B 1 137 ? 73.104  95.377  96.902  1.00 74.73 ? 137 VAL B CA  1 
ATOM 1989 C C   . VAL B 1 137 ? 73.007  96.479  97.964  1.00 74.91 ? 137 VAL B C   1 
ATOM 1990 O O   . VAL B 1 137 ? 73.641  97.525  97.825  1.00 69.84 ? 137 VAL B O   1 
ATOM 1991 C CB  . VAL B 1 137 ? 71.984  95.528  95.860  1.00 70.29 ? 137 VAL B CB  1 
ATOM 1992 C CG1 . VAL B 1 137 ? 72.173  96.797  95.031  1.00 64.55 ? 137 VAL B CG1 1 
ATOM 1993 C CG2 . VAL B 1 137 ? 71.930  94.349  94.881  1.00 64.51 ? 137 VAL B CG2 1 
ATOM 1994 N N   . ASN B 1 138 ? 72.264  96.237  99.037  1.00 73.67 ? 138 ASN B N   1 
ATOM 1995 C CA  . ASN B 1 138 ? 72.125  97.215  100.118 1.00 70.87 ? 138 ASN B CA  1 
ATOM 1996 C C   . ASN B 1 138 ? 73.413  97.389  100.928 1.00 71.59 ? 138 ASN B C   1 
ATOM 1997 O O   . ASN B 1 138 ? 73.697  98.487  101.404 1.00 65.32 ? 138 ASN B O   1 
ATOM 1998 C CB  . ASN B 1 138 ? 70.946  96.821  101.010 1.00 64.23 ? 138 ASN B CB  1 
ATOM 1999 C CG  . ASN B 1 138 ? 69.613  97.048  100.312 1.00 58.69 ? 138 ASN B CG  1 
ATOM 2000 O OD1 . ASN B 1 138 ? 69.461  97.909  99.465  1.00 52.34 ? 138 ASN B OD1 1 
ATOM 2001 N ND2 . ASN B 1 138 ? 68.610  96.290  100.687 1.00 51.59 ? 138 ASN B ND2 1 
ATOM 2002 N N   . MET B 1 139 ? 74.241  96.344  101.010 1.00 68.84 ? 139 MET B N   1 
ATOM 2003 C CA  . MET B 1 139 ? 75.585  96.443  101.598 1.00 66.04 ? 139 MET B CA  1 
ATOM 2004 C C   . MET B 1 139 ? 76.601  97.151  100.685 1.00 69.32 ? 139 MET B C   1 
ATOM 2005 O O   . MET B 1 139 ? 77.797  97.138  100.970 1.00 62.55 ? 139 MET B O   1 
ATOM 2006 C CB  . MET B 1 139 ? 76.087  95.071  102.052 1.00 57.95 ? 139 MET B CB  1 
ATOM 2007 C CG  . MET B 1 139 ? 75.287  94.523  103.234 1.00 50.95 ? 139 MET B CG  1 
ATOM 2008 S SD  . MET B 1 139 ? 76.189  93.213  104.103 1.00 43.25 ? 139 MET B SD  1 
ATOM 2009 C CE  . MET B 1 139 ? 74.881  92.629  105.213 1.00 37.56 ? 139 MET B CE  1 
ATOM 2010 N N   . ARG B 1 140 ? 76.151  97.800  99.612  1.00 75.34 ? 140 ARG B N   1 
ATOM 2011 C CA  . ARG B 1 140 ? 76.979  98.576  98.678  1.00 75.78 ? 140 ARG B CA  1 
ATOM 2012 C C   . ARG B 1 140 ? 78.077  97.753  97.973  1.00 79.47 ? 140 ARG B C   1 
ATOM 2013 O O   . ARG B 1 140 ? 79.067  98.325  97.525  1.00 74.24 ? 140 ARG B O   1 
ATOM 2014 C CB  . ARG B 1 140 ? 77.543  99.827  99.354  1.00 68.63 ? 140 ARG B CB  1 
ATOM 2015 C CG  . ARG B 1 140 ? 76.456  100.747 99.935  1.00 59.76 ? 140 ARG B CG  1 
ATOM 2016 C CD  . ARG B 1 140 ? 77.128  101.985 100.533 1.00 54.25 ? 140 ARG B CD  1 
ATOM 2017 N NE  . ARG B 1 140 ? 76.129  102.966 100.962 1.00 47.79 ? 140 ARG B NE  1 
ATOM 2018 C CZ  . ARG B 1 140 ? 76.345  104.154 101.519 1.00 40.92 ? 140 ARG B CZ  1 
ATOM 2019 N NH1 . ARG B 1 140 ? 77.560  104.567 101.769 1.00 37.45 ? 140 ARG B NH1 1 
ATOM 2020 N NH2 . ARG B 1 140 ? 75.335  104.914 101.808 1.00 35.57 ? 140 ARG B NH2 1 
ATOM 2021 N N   . HIS B 1 141 ? 77.892  96.441  97.851  1.00 82.46 ? 141 HIS B N   1 
ATOM 2022 C CA  . HIS B 1 141 ? 78.733  95.604  96.991  1.00 82.36 ? 141 HIS B CA  1 
ATOM 2023 C C   . HIS B 1 141 ? 78.536  95.950  95.506  1.00 85.03 ? 141 HIS B C   1 
ATOM 2024 O O   . HIS B 1 141 ? 79.488  95.939  94.735  1.00 81.55 ? 141 HIS B O   1 
ATOM 2025 C CB  . HIS B 1 141 ? 78.450  94.125  97.263  1.00 77.79 ? 141 HIS B CB  1 
ATOM 2026 C CG  . HIS B 1 141 ? 78.915  93.685  98.622  1.00 72.76 ? 141 HIS B CG  1 
ATOM 2027 N ND1 . HIS B 1 141 ? 80.167  93.210  98.938  1.00 63.37 ? 141 HIS B ND1 1 
ATOM 2028 C CD2 . HIS B 1 141 ? 78.204  93.680  99.793  1.00 62.38 ? 141 HIS B CD2 1 
ATOM 2029 C CE1 . HIS B 1 141 ? 80.198  92.920  100.245 1.00 59.12 ? 141 HIS B CE1 1 
ATOM 2030 N NE2 . HIS B 1 141 ? 79.021  93.204  100.800 1.00 59.47 ? 141 HIS B NE2 1 
ATOM 2031 N N   . ALA B 1 142 ? 77.303  96.323  95.129  1.00 88.73 ? 142 ALA B N   1 
ATOM 2032 C CA  . ALA B 1 142 ? 76.945  96.854  93.823  1.00 90.38 ? 142 ALA B CA  1 
ATOM 2033 C C   . ALA B 1 142 ? 75.952  98.021  93.951  1.00 90.92 ? 142 ALA B C   1 
ATOM 2034 O O   . ALA B 1 142 ? 75.380  98.250  95.019  1.00 89.00 ? 142 ALA B O   1 
ATOM 2035 C CB  . ALA B 1 142 ? 76.381  95.708  92.977  1.00 89.03 ? 142 ALA B CB  1 
ATOM 2036 N N   . ASP B 1 143 ? 75.751  98.764  92.854  1.00 93.29 ? 143 ASP B N   1 
ATOM 2037 C CA  . ASP B 1 143 ? 74.777  99.862  92.797  1.00 93.12 ? 143 ASP B CA  1 
ATOM 2038 C C   . ASP B 1 143 ? 73.389  99.377  92.335  1.00 93.42 ? 143 ASP B C   1 
ATOM 2039 O O   . ASP B 1 143 ? 72.369  100.008 92.629  1.00 92.31 ? 143 ASP B O   1 
ATOM 2040 C CB  . ASP B 1 143 ? 75.286  100.945 91.843  1.00 92.44 ? 143 ASP B CB  1 
ATOM 2041 C CG  . ASP B 1 143 ? 76.646  101.553 92.219  1.00 92.12 ? 143 ASP B CG  1 
ATOM 2042 O OD1 . ASP B 1 143 ? 76.827  101.982 93.376  1.00 88.21 ? 143 ASP B OD1 1 
ATOM 2043 O OD2 . ASP B 1 143 ? 77.513  101.654 91.322  1.00 87.91 ? 143 ASP B OD2 1 
ATOM 2044 N N   . CYS B 1 144 ? 73.342  98.282  91.585  1.00 94.57 ? 144 CYS B N   1 
ATOM 2045 C CA  . CYS B 1 144 ? 72.134  97.627  91.096  1.00 95.01 ? 144 CYS B CA  1 
ATOM 2046 C C   . CYS B 1 144 ? 72.397  96.157  90.766  1.00 95.24 ? 144 CYS B C   1 
ATOM 2047 O O   . CYS B 1 144 ? 73.554  95.726  90.677  1.00 94.75 ? 144 CYS B O   1 
ATOM 2048 C CB  . CYS B 1 144 ? 71.592  98.402  89.878  1.00 94.92 ? 144 CYS B CB  1 
ATOM 2049 S SG  . CYS B 1 144 ? 72.795  98.478  88.526  1.00 94.34 ? 144 CYS B SG  1 
ATOM 2050 N N   . ALA B 1 145 ? 71.323  95.396  90.551  1.00 95.48 ? 145 ALA B N   1 
ATOM 2051 C CA  . ALA B 1 145 ? 71.417  93.981  90.218  1.00 95.42 ? 145 ALA B CA  1 
ATOM 2052 C C   . ALA B 1 145 ? 70.381  93.553  89.172  1.00 95.78 ? 145 ALA B C   1 
ATOM 2053 O O   . ALA B 1 145 ? 69.281  94.105  89.112  1.00 95.26 ? 145 ALA B O   1 
ATOM 2054 C CB  . ALA B 1 145 ? 71.271  93.157  91.501  1.00 94.58 ? 145 ALA B CB  1 
ATOM 2055 N N   . ILE B 1 146 ? 70.702  92.517  88.412  1.00 95.88 ? 146 ILE B N   1 
ATOM 2056 C CA  . ILE B 1 146 ? 69.725  91.711  87.680  1.00 95.85 ? 146 ILE B CA  1 
ATOM 2057 C C   . ILE B 1 146 ? 69.632  90.353  88.383  1.00 95.39 ? 146 ILE B C   1 
ATOM 2058 O O   . ILE B 1 146 ? 70.631  89.649  88.513  1.00 94.40 ? 146 ILE B O   1 
ATOM 2059 C CB  . ILE B 1 146 ? 70.067  91.582  86.182  1.00 96.00 ? 146 ILE B CB  1 
ATOM 2060 C CG1 . ILE B 1 146 ? 70.196  92.974  85.536  1.00 94.50 ? 146 ILE B CG1 1 
ATOM 2061 C CG2 . ILE B 1 146 ? 68.979  90.755  85.478  1.00 94.15 ? 146 ILE B CG2 1 
ATOM 2062 C CD1 . ILE B 1 146 ? 70.693  92.948  84.075  1.00 90.25 ? 146 ILE B CD1 1 
ATOM 2063 N N   . ARG B 1 147 ? 68.429  90.007  88.846  1.00 95.02 ? 147 ARG B N   1 
ATOM 2064 C CA  . ARG B 1 147 ? 68.144  88.769  89.583  1.00 94.63 ? 147 ARG B CA  1 
ATOM 2065 C C   . ARG B 1 147 ? 67.303  87.813  88.734  1.00 94.51 ? 147 ARG B C   1 
ATOM 2066 O O   . ARG B 1 147 ? 66.449  88.267  87.974  1.00 93.50 ? 147 ARG B O   1 
ATOM 2067 C CB  . ARG B 1 147 ? 67.417  89.088  90.901  1.00 93.48 ? 147 ARG B CB  1 
ATOM 2068 C CG  . ARG B 1 147 ? 68.184  90.002  91.871  1.00 90.54 ? 147 ARG B CG  1 
ATOM 2069 C CD  . ARG B 1 147 ? 69.510  89.385  92.321  1.00 88.19 ? 147 ARG B CD  1 
ATOM 2070 N NE  . ARG B 1 147 ? 70.101  90.165  93.419  1.00 86.43 ? 147 ARG B NE  1 
ATOM 2071 C CZ  . ARG B 1 147 ? 71.367  90.141  93.795  1.00 83.90 ? 147 ARG B CZ  1 
ATOM 2072 N NH1 . ARG B 1 147 ? 72.258  89.416  93.180  1.00 76.72 ? 147 ARG B NH1 1 
ATOM 2073 N NH2 . ARG B 1 147 ? 71.751  90.864  94.797  1.00 80.23 ? 147 ARG B NH2 1 
ATOM 2074 N N   . LEU B 1 148 ? 67.506  86.516  88.907  1.00 93.67 ? 148 LEU B N   1 
ATOM 2075 C CA  . LEU B 1 148 ? 66.719  85.463  88.250  1.00 92.98 ? 148 LEU B CA  1 
ATOM 2076 C C   . LEU B 1 148 ? 65.456  85.073  89.033  1.00 92.17 ? 148 LEU B C   1 
ATOM 2077 O O   . LEU B 1 148 ? 64.725  84.169  88.635  1.00 88.74 ? 148 LEU B O   1 
ATOM 2078 C CB  . LEU B 1 148 ? 67.603  84.236  87.980  1.00 91.75 ? 148 LEU B CB  1 
ATOM 2079 C CG  . LEU B 1 148 ? 68.871  84.484  87.147  1.00 90.23 ? 148 LEU B CG  1 
ATOM 2080 C CD1 . LEU B 1 148 ? 69.495  83.126  86.786  1.00 82.96 ? 148 LEU B CD1 1 
ATOM 2081 C CD2 . LEU B 1 148 ? 68.610  85.236  85.854  1.00 82.48 ? 148 LEU B CD2 1 
ATOM 2082 N N   . ARG B 1 149 ? 65.196  85.729  90.159  1.00 92.26 ? 149 ARG B N   1 
ATOM 2083 C CA  . ARG B 1 149 ? 63.982  85.608  90.961  1.00 91.46 ? 149 ARG B CA  1 
ATOM 2084 C C   . ARG B 1 149 ? 63.558  86.973  91.471  1.00 92.28 ? 149 ARG B C   1 
ATOM 2085 O O   . ARG B 1 149 ? 64.367  87.903  91.506  1.00 90.73 ? 149 ARG B O   1 
ATOM 2086 C CB  . ARG B 1 149 ? 64.182  84.590  92.096  1.00 88.45 ? 149 ARG B CB  1 
ATOM 2087 C CG  . ARG B 1 149 ? 65.225  85.039  93.139  1.00 82.97 ? 149 ARG B CG  1 
ATOM 2088 C CD  . ARG B 1 149 ? 65.383  83.968  94.232  1.00 80.99 ? 149 ARG B CD  1 
ATOM 2089 N NE  . ARG B 1 149 ? 66.384  84.371  95.221  1.00 75.65 ? 149 ARG B NE  1 
ATOM 2090 C CZ  . ARG B 1 149 ? 66.783  83.670  96.268  1.00 72.41 ? 149 ARG B CZ  1 
ATOM 2091 N NH1 . ARG B 1 149 ? 66.276  82.507  96.560  1.00 67.59 ? 149 ARG B NH1 1 
ATOM 2092 N NH2 . ARG B 1 149 ? 67.712  84.139  97.033  1.00 66.46 ? 149 ARG B NH2 1 
ATOM 2093 N N   . GLN B 1 150 ? 62.308  87.098  91.893  1.00 91.24 ? 150 GLN B N   1 
ATOM 2094 C CA  . GLN B 1 150 ? 61.825  88.349  92.455  1.00 91.37 ? 150 GLN B CA  1 
ATOM 2095 C C   . GLN B 1 150 ? 62.553  88.667  93.768  1.00 90.87 ? 150 GLN B C   1 
ATOM 2096 O O   . GLN B 1 150 ? 62.500  87.863  94.694  1.00 88.63 ? 150 GLN B O   1 
ATOM 2097 C CB  . GLN B 1 150 ? 60.301  88.282  92.641  1.00 90.55 ? 150 GLN B CB  1 
ATOM 2098 C CG  . GLN B 1 150 ? 59.744  89.660  93.019  1.00 87.36 ? 150 GLN B CG  1 
ATOM 2099 C CD  . GLN B 1 150 ? 58.212  89.717  93.064  1.00 85.13 ? 150 GLN B CD  1 
ATOM 2100 O OE1 . GLN B 1 150 ? 57.512  88.724  93.021  1.00 79.13 ? 150 GLN B OE1 1 
ATOM 2101 N NE2 . GLN B 1 150 ? 57.653  90.904  93.165  1.00 76.80 ? 150 GLN B NE2 1 
ATOM 2102 N N   . PRO B 1 151 ? 63.209  89.844  93.870  1.00 90.52 ? 151 PRO B N   1 
ATOM 2103 C CA  . PRO B 1 151 ? 63.827  90.275  95.119  1.00 89.71 ? 151 PRO B CA  1 
ATOM 2104 C C   . PRO B 1 151 ? 62.789  90.365  96.243  1.00 89.12 ? 151 PRO B C   1 
ATOM 2105 O O   . PRO B 1 151 ? 61.709  90.924  96.052  1.00 86.44 ? 151 PRO B O   1 
ATOM 2106 C CB  . PRO B 1 151 ? 64.464  91.630  94.821  1.00 87.95 ? 151 PRO B CB  1 
ATOM 2107 C CG  . PRO B 1 151 ? 64.677  91.609  93.310  1.00 86.07 ? 151 PRO B CG  1 
ATOM 2108 C CD  . PRO B 1 151 ? 63.476  90.807  92.816  1.00 89.15 ? 151 PRO B CD  1 
ATOM 2109 N N   . GLN B 1 152 ? 63.135  89.823  97.402  1.00 87.89 ? 152 GLN B N   1 
ATOM 2110 C CA  . GLN B 1 152 ? 62.270  89.805  98.581  1.00 85.76 ? 152 GLN B CA  1 
ATOM 2111 C C   . GLN B 1 152 ? 62.538  90.968  99.554  1.00 84.95 ? 152 GLN B C   1 
ATOM 2112 O O   . GLN B 1 152 ? 61.729  91.220  100.440 1.00 80.27 ? 152 GLN B O   1 
ATOM 2113 C CB  . GLN B 1 152 ? 62.422  88.453  99.302  1.00 83.14 ? 152 GLN B CB  1 
ATOM 2114 C CG  . GLN B 1 152 ? 61.989  87.248  98.441  1.00 75.85 ? 152 GLN B CG  1 
ATOM 2115 C CD  . GLN B 1 152 ? 60.506  87.288  98.050  1.00 68.79 ? 152 GLN B CD  1 
ATOM 2116 O OE1 . GLN B 1 152 ? 59.637  87.504  98.876  1.00 61.45 ? 152 GLN B OE1 1 
ATOM 2117 N NE2 . GLN B 1 152 ? 60.188  87.085  96.792  1.00 59.00 ? 152 GLN B NE2 1 
ATOM 2118 N N   . GLN B 1 153 ? 63.656  91.677  99.373  1.00 84.28 ? 153 GLN B N   1 
ATOM 2119 C CA  . GLN B 1 153 ? 63.969  92.845  100.194 1.00 82.67 ? 153 GLN B CA  1 
ATOM 2120 C C   . GLN B 1 153 ? 63.013  93.997  99.879  1.00 83.42 ? 153 GLN B C   1 
ATOM 2121 O O   . GLN B 1 153 ? 62.871  94.428  98.734  1.00 80.08 ? 153 GLN B O   1 
ATOM 2122 C CB  . GLN B 1 153 ? 65.437  93.255  99.996  1.00 78.67 ? 153 GLN B CB  1 
ATOM 2123 C CG  . GLN B 1 153 ? 66.404  92.407  100.837 1.00 69.77 ? 153 GLN B CG  1 
ATOM 2124 C CD  . GLN B 1 153 ? 67.863  92.779  100.588 1.00 65.66 ? 153 GLN B CD  1 
ATOM 2125 O OE1 . GLN B 1 153 ? 68.242  93.195  99.507  1.00 59.79 ? 153 GLN B OE1 1 
ATOM 2126 N NE2 . GLN B 1 153 ? 68.732  92.632  101.567 1.00 57.35 ? 153 GLN B NE2 1 
ATOM 2127 N N   . SER B 1 154 ? 62.338  94.514  100.927 1.00 81.90 ? 154 SER B N   1 
ATOM 2128 C CA  . SER B 1 154 ? 61.317  95.564  100.813 1.00 81.00 ? 154 SER B CA  1 
ATOM 2129 C C   . SER B 1 154 ? 61.880  96.961  100.507 1.00 81.24 ? 154 SER B C   1 
ATOM 2130 O O   . SER B 1 154 ? 61.141  97.847  100.091 1.00 75.05 ? 154 SER B O   1 
ATOM 2131 C CB  . SER B 1 154 ? 60.516  95.622  102.113 1.00 77.00 ? 154 SER B CB  1 
ATOM 2132 O OG  . SER B 1 154 ? 61.361  95.748  103.233 1.00 68.47 ? 154 SER B OG  1 
ATOM 2133 N N   . ASP B 1 155 ? 63.157  97.151  100.707 1.00 84.22 ? 155 ASP B N   1 
ATOM 2134 C CA  . ASP B 1 155 ? 63.915  98.385  100.508 1.00 84.23 ? 155 ASP B CA  1 
ATOM 2135 C C   . ASP B 1 155 ? 64.584  98.473  99.127  1.00 86.10 ? 155 ASP B C   1 
ATOM 2136 O O   . ASP B 1 155 ? 65.236  99.468  98.808  1.00 83.23 ? 155 ASP B O   1 
ATOM 2137 C CB  . ASP B 1 155 ? 64.924  98.527  101.661 1.00 80.11 ? 155 ASP B CB  1 
ATOM 2138 C CG  . ASP B 1 155 ? 65.888  97.333  101.817 1.00 72.10 ? 155 ASP B CG  1 
ATOM 2139 O OD1 . ASP B 1 155 ? 65.572  96.218  101.335 1.00 64.38 ? 155 ASP B OD1 1 
ATOM 2140 O OD2 . ASP B 1 155 ? 66.935  97.519  102.474 1.00 65.30 ? 155 ASP B OD2 1 
ATOM 2141 N N   . LEU B 1 156 ? 64.383  97.463  98.269  1.00 88.37 ? 156 LEU B N   1 
ATOM 2142 C CA  . LEU B 1 156 ? 64.806  97.469  96.876  1.00 89.68 ? 156 LEU B CA  1 
ATOM 2143 C C   . LEU B 1 156 ? 63.661  97.896  95.952  1.00 90.62 ? 156 LEU B C   1 
ATOM 2144 O O   . LEU B 1 156 ? 62.594  97.274  95.908  1.00 89.10 ? 156 LEU B O   1 
ATOM 2145 C CB  . LEU B 1 156 ? 65.355  96.091  96.473  1.00 88.21 ? 156 LEU B CB  1 
ATOM 2146 C CG  . LEU B 1 156 ? 66.681  95.714  97.155  1.00 86.15 ? 156 LEU B CG  1 
ATOM 2147 C CD1 . LEU B 1 156 ? 67.107  94.318  96.689  1.00 82.28 ? 156 LEU B CD1 1 
ATOM 2148 C CD2 . LEU B 1 156 ? 67.810  96.690  96.806  1.00 82.17 ? 156 LEU B CD2 1 
ATOM 2149 N N   . ILE B 1 157 ? 63.912  98.915  95.139  1.00 92.24 ? 157 ILE B N   1 
ATOM 2150 C CA  . ILE B 1 157 ? 63.088  99.215  93.971  1.00 92.51 ? 157 ILE B CA  1 
ATOM 2151 C C   . ILE B 1 157 ? 63.362  98.138  92.926  1.00 92.77 ? 157 ILE B C   1 
ATOM 2152 O O   . ILE B 1 157 ? 64.517  97.864  92.606  1.00 92.01 ? 157 ILE B O   1 
ATOM 2153 C CB  . ILE B 1 157 ? 63.377  100.630 93.440  1.00 91.81 ? 157 ILE B CB  1 
ATOM 2154 C CG1 . ILE B 1 157 ? 63.097  101.686 94.533  1.00 89.55 ? 157 ILE B CG1 1 
ATOM 2155 C CG2 . ILE B 1 157 ? 62.528  100.916 92.185  1.00 89.32 ? 157 ILE B CG2 1 
ATOM 2156 C CD1 . ILE B 1 157 ? 63.540  103.113 94.165  1.00 83.97 ? 157 ILE B CD1 1 
ATOM 2157 N N   . GLN B 1 158 ? 62.303  97.542  92.381  1.00 93.40 ? 158 GLN B N   1 
ATOM 2158 C CA  . GLN B 1 158 ? 62.415  96.470  91.399  1.00 92.92 ? 158 GLN B CA  1 
ATOM 2159 C C   . GLN B 1 158 ? 61.510  96.686  90.186  1.00 92.80 ? 158 GLN B C   1 
ATOM 2160 O O   . GLN B 1 158 ? 60.417  97.233  90.278  1.00 90.98 ? 158 GLN B O   1 
ATOM 2161 C CB  . GLN B 1 158 ? 62.190  95.107  92.076  1.00 90.16 ? 158 GLN B CB  1 
ATOM 2162 C CG  . GLN B 1 158 ? 60.827  94.969  92.762  1.00 83.77 ? 158 GLN B CG  1 
ATOM 2163 C CD  . GLN B 1 158 ? 60.625  93.558  93.323  1.00 85.69 ? 158 GLN B CD  1 
ATOM 2164 O OE1 . GLN B 1 158 ? 60.475  92.612  92.573  1.00 77.09 ? 158 GLN B OE1 1 
ATOM 2165 N NE2 . GLN B 1 158 ? 60.602  93.385  94.622  1.00 76.29 ? 158 GLN B NE2 1 
ATOM 2166 N N   . ARG B 1 159 ? 61.970  96.216  89.016  1.00 92.09 ? 159 ARG B N   1 
ATOM 2167 C CA  . ARG B 1 159 ? 61.181  96.107  87.786  1.00 91.35 ? 159 ARG B CA  1 
ATOM 2168 C C   . ARG B 1 159 ? 61.387  94.728  87.181  1.00 92.63 ? 159 ARG B C   1 
ATOM 2169 O O   . ARG B 1 159 ? 62.520  94.315  86.969  1.00 91.18 ? 159 ARG B O   1 
ATOM 2170 C CB  . ARG B 1 159 ? 61.574  97.181  86.775  1.00 88.36 ? 159 ARG B CB  1 
ATOM 2171 C CG  . ARG B 1 159 ? 61.091  98.587  87.178  1.00 79.38 ? 159 ARG B CG  1 
ATOM 2172 C CD  . ARG B 1 159 ? 61.276  99.539  85.997  1.00 75.39 ? 159 ARG B CD  1 
ATOM 2173 N NE  . ARG B 1 159 ? 60.760  100.895 86.284  1.00 70.12 ? 159 ARG B NE  1 
ATOM 2174 C CZ  . ARG B 1 159 ? 60.644  101.874 85.407  1.00 62.88 ? 159 ARG B CZ  1 
ATOM 2175 N NH1 . ARG B 1 159 ? 60.963  101.722 84.149  1.00 57.57 ? 159 ARG B NH1 1 
ATOM 2176 N NH2 . ARG B 1 159 ? 60.215  103.040 85.787  1.00 56.71 ? 159 ARG B NH2 1 
ATOM 2177 N N   . LYS B 1 160 ? 60.280  94.064  86.832  1.00 90.02 ? 160 LYS B N   1 
ATOM 2178 C CA  . LYS B 1 160 ? 60.340  92.869  85.982  1.00 89.69 ? 160 LYS B CA  1 
ATOM 2179 C C   . LYS B 1 160 ? 60.950  93.239  84.630  1.00 89.46 ? 160 LYS B C   1 
ATOM 2180 O O   . LYS B 1 160 ? 60.570  94.258  84.048  1.00 88.08 ? 160 LYS B O   1 
ATOM 2181 C CB  . LYS B 1 160 ? 58.926  92.255  85.850  1.00 87.88 ? 160 LYS B CB  1 
ATOM 2182 C CG  . LYS B 1 160 ? 58.927  91.017  84.933  1.00 83.78 ? 160 LYS B CG  1 
ATOM 2183 C CD  . LYS B 1 160 ? 57.577  90.288  84.906  1.00 79.63 ? 160 LYS B CD  1 
ATOM 2184 C CE  . LYS B 1 160 ? 57.640  89.221  83.808  1.00 71.61 ? 160 LYS B CE  1 
ATOM 2185 N NZ  . LYS B 1 160 ? 56.582  88.197  83.903  1.00 65.08 ? 160 LYS B NZ  1 
ATOM 2186 N N   . LEU B 1 161 ? 61.871  92.421  84.139  1.00 91.87 ? 161 LEU B N   1 
ATOM 2187 C CA  . LEU B 1 161 ? 62.513  92.583  82.835  1.00 91.88 ? 161 LEU B CA  1 
ATOM 2188 C C   . LEU B 1 161 ? 61.829  91.689  81.793  1.00 90.57 ? 161 LEU B C   1 
ATOM 2189 O O   . LEU B 1 161 ? 60.905  92.142  81.115  1.00 88.08 ? 161 LEU B O   1 
ATOM 2190 C CB  . LEU B 1 161 ? 64.025  92.333  82.960  1.00 92.25 ? 161 LEU B CB  1 
ATOM 2191 C CG  . LEU B 1 161 ? 64.802  93.364  83.796  1.00 92.55 ? 161 LEU B CG  1 
ATOM 2192 C CD1 . LEU B 1 161 ? 66.271  92.941  83.851  1.00 89.77 ? 161 LEU B CD1 1 
ATOM 2193 C CD2 . LEU B 1 161 ? 64.719  94.767  83.201  1.00 89.63 ? 161 LEU B CD2 1 
ATOM 2194 N N   . PHE B 1 162 ? 62.242  90.434  81.689  1.00 90.76 ? 162 PHE B N   1 
ATOM 2195 C CA  . PHE B 1 162 ? 61.723  89.455  80.747  1.00 90.47 ? 162 PHE B CA  1 
ATOM 2196 C C   . PHE B 1 162 ? 61.503  88.101  81.438  1.00 91.28 ? 162 PHE B C   1 
ATOM 2197 O O   . PHE B 1 162 ? 62.060  87.841  82.508  1.00 90.65 ? 162 PHE B O   1 
ATOM 2198 C CB  . PHE B 1 162 ? 62.669  89.333  79.537  1.00 88.71 ? 162 PHE B CB  1 
ATOM 2199 C CG  . PHE B 1 162 ? 64.128  89.100  79.887  1.00 88.53 ? 162 PHE B CG  1 
ATOM 2200 C CD1 . PHE B 1 162 ? 65.009  90.199  79.944  1.00 82.03 ? 162 PHE B CD1 1 
ATOM 2201 C CD2 . PHE B 1 162 ? 64.617  87.815  80.140  1.00 82.46 ? 162 PHE B CD2 1 
ATOM 2202 C CE1 . PHE B 1 162 ? 66.364  89.999  80.255  1.00 78.96 ? 162 PHE B CE1 1 
ATOM 2203 C CE2 . PHE B 1 162 ? 65.974  87.615  80.453  1.00 79.24 ? 162 PHE B CE2 1 
ATOM 2204 C CZ  . PHE B 1 162 ? 66.846  88.711  80.509  1.00 82.22 ? 162 PHE B CZ  1 
ATOM 2205 N N   . THR B 1 163 ? 60.676  87.270  80.808  1.00 90.03 ? 163 THR B N   1 
ATOM 2206 C CA  . THR B 1 163 ? 60.506  85.870  81.202  1.00 89.69 ? 163 THR B CA  1 
ATOM 2207 C C   . THR B 1 163 ? 61.560  85.033  80.493  1.00 89.40 ? 163 THR B C   1 
ATOM 2208 O O   . THR B 1 163 ? 61.784  85.216  79.295  1.00 88.63 ? 163 THR B O   1 
ATOM 2209 C CB  . THR B 1 163 ? 59.092  85.381  80.871  1.00 88.50 ? 163 THR B CB  1 
ATOM 2210 O OG1 . THR B 1 163 ? 58.132  86.238  81.460  1.00 83.98 ? 163 THR B OG1 1 
ATOM 2211 C CG2 . THR B 1 163 ? 58.821  83.980  81.410  1.00 83.27 ? 163 THR B CG2 1 
ATOM 2212 N N   . VAL B 1 164 ? 62.205  84.141  81.221  1.00 92.12 ? 164 VAL B N   1 
ATOM 2213 C CA  . VAL B 1 164 ? 63.187  83.193  80.706  1.00 92.28 ? 164 VAL B CA  1 
ATOM 2214 C C   . VAL B 1 164 ? 62.511  81.842  80.517  1.00 92.29 ? 164 VAL B C   1 
ATOM 2215 O O   . VAL B 1 164 ? 61.858  81.332  81.431  1.00 91.47 ? 164 VAL B O   1 
ATOM 2216 C CB  . VAL B 1 164 ? 64.386  83.060  81.651  1.00 91.76 ? 164 VAL B CB  1 
ATOM 2217 C CG1 . VAL B 1 164 ? 65.429  82.082  81.103  1.00 88.73 ? 164 VAL B CG1 1 
ATOM 2218 C CG2 . VAL B 1 164 ? 65.069  84.419  81.876  1.00 88.87 ? 164 VAL B CG2 1 
ATOM 2219 N N   . HIS B 1 165 ? 62.717  81.247  79.354  1.00 91.17 ? 165 HIS B N   1 
ATOM 2220 C CA  . HIS B 1 165 ? 62.308  79.888  79.053  1.00 90.68 ? 165 HIS B CA  1 
ATOM 2221 C C   . HIS B 1 165 ? 63.533  78.974  79.007  1.00 91.33 ? 165 HIS B C   1 
ATOM 2222 O O   . HIS B 1 165 ? 64.586  79.334  78.488  1.00 90.84 ? 165 HIS B O   1 
ATOM 2223 C CB  . HIS B 1 165 ? 61.505  79.867  77.751  1.00 88.85 ? 165 HIS B CB  1 
ATOM 2224 C CG  . HIS B 1 165 ? 60.232  80.674  77.858  1.00 85.87 ? 165 HIS B CG  1 
ATOM 2225 N ND1 . HIS B 1 165 ? 59.053  80.240  78.432  1.00 76.46 ? 165 HIS B ND1 1 
ATOM 2226 C CD2 . HIS B 1 165 ? 60.030  81.974  77.462  1.00 76.15 ? 165 HIS B CD2 1 
ATOM 2227 C CE1 . HIS B 1 165 ? 58.165  81.256  78.374  1.00 76.79 ? 165 HIS B CE1 1 
ATOM 2228 N NE2 . HIS B 1 165 ? 58.720  82.326  77.798  1.00 77.49 ? 165 HIS B NE2 1 
ATOM 2229 N N   . MET B 1 166 ? 63.380  77.776  79.570  1.00 92.43 ? 166 MET B N   1 
ATOM 2230 C CA  . MET B 1 166 ? 64.362  76.697  79.472  1.00 92.87 ? 166 MET B CA  1 
ATOM 2231 C C   . MET B 1 166 ? 63.921  75.742  78.374  1.00 92.86 ? 166 MET B C   1 
ATOM 2232 O O   . MET B 1 166 ? 62.757  75.331  78.330  1.00 91.33 ? 166 MET B O   1 
ATOM 2233 C CB  . MET B 1 166 ? 64.470  75.959  80.812  1.00 92.16 ? 166 MET B CB  1 
ATOM 2234 C CG  . MET B 1 166 ? 64.956  76.840  81.979  1.00 87.91 ? 166 MET B CG  1 
ATOM 2235 S SD  . MET B 1 166 ? 66.710  77.300  81.932  1.00 86.21 ? 166 MET B SD  1 
ATOM 2236 C CE  . MET B 1 166 ? 67.487  75.727  82.384  1.00 77.44 ? 166 MET B CE  1 
ATOM 2237 N N   . HIS B 1 167 ? 64.844  75.346  77.507  1.00 93.41 ? 167 HIS B N   1 
ATOM 2238 C CA  . HIS B 1 167 ? 64.610  74.341  76.479  1.00 93.34 ? 167 HIS B CA  1 
ATOM 2239 C C   . HIS B 1 167 ? 65.752  73.321  76.443  1.00 94.20 ? 167 HIS B C   1 
ATOM 2240 O O   . HIS B 1 167 ? 66.847  73.565  76.956  1.00 93.97 ? 167 HIS B O   1 
ATOM 2241 C CB  . HIS B 1 167 ? 64.394  75.009  75.122  1.00 91.68 ? 167 HIS B CB  1 
ATOM 2242 C CG  . HIS B 1 167 ? 63.175  75.880  75.048  1.00 89.20 ? 167 HIS B CG  1 
ATOM 2243 N ND1 . HIS B 1 167 ? 61.862  75.437  75.036  1.00 77.85 ? 167 HIS B ND1 1 
ATOM 2244 C CD2 . HIS B 1 167 ? 63.131  77.251  74.990  1.00 77.08 ? 167 HIS B CD2 1 
ATOM 2245 C CE1 . HIS B 1 167 ? 61.063  76.519  74.968  1.00 77.85 ? 167 HIS B CE1 1 
ATOM 2246 N NE2 . HIS B 1 167 ? 61.795  77.634  74.939  1.00 79.39 ? 167 HIS B NE2 1 
ATOM 2247 N N   . VAL B 1 168 ? 65.471  72.182  75.833  1.00 94.55 ? 168 VAL B N   1 
ATOM 2248 C CA  . VAL B 1 168 ? 66.450  71.111  75.643  1.00 95.27 ? 168 VAL B CA  1 
ATOM 2249 C C   . VAL B 1 168 ? 67.056  71.236  74.248  1.00 95.04 ? 168 VAL B C   1 
ATOM 2250 O O   . VAL B 1 168 ? 66.332  71.422  73.275  1.00 94.15 ? 168 VAL B O   1 
ATOM 2251 C CB  . VAL B 1 168 ? 65.811  69.731  75.881  1.00 95.17 ? 168 VAL B CB  1 
ATOM 2252 C CG1 . VAL B 1 168 ? 66.863  68.628  75.787  1.00 92.96 ? 168 VAL B CG1 1 
ATOM 2253 C CG2 . VAL B 1 168 ? 65.172  69.655  77.274  1.00 92.47 ? 168 VAL B CG2 1 
ATOM 2254 N N   . TYR B 1 169 ? 68.377  71.117  74.156  1.00 95.13 ? 169 TYR B N   1 
ATOM 2255 C CA  . TYR B 1 169 ? 69.125  71.314  72.923  1.00 95.32 ? 169 TYR B CA  1 
ATOM 2256 C C   . TYR B 1 169 ? 70.149  70.206  72.687  1.00 95.99 ? 169 TYR B C   1 
ATOM 2257 O O   . TYR B 1 169 ? 70.712  69.641  73.626  1.00 95.66 ? 169 TYR B O   1 
ATOM 2258 C CB  . TYR B 1 169 ? 69.832  72.670  72.949  1.00 94.53 ? 169 TYR B CB  1 
ATOM 2259 C CG  . TYR B 1 169 ? 68.900  73.865  73.060  1.00 93.96 ? 169 TYR B CG  1 
ATOM 2260 C CD1 . TYR B 1 169 ? 68.323  74.418  71.905  1.00 91.03 ? 169 TYR B CD1 1 
ATOM 2261 C CD2 . TYR B 1 169 ? 68.616  74.426  74.319  1.00 90.88 ? 169 TYR B CD2 1 
ATOM 2262 C CE1 . TYR B 1 169 ? 67.471  75.529  71.999  1.00 89.53 ? 169 TYR B CE1 1 
ATOM 2263 C CE2 . TYR B 1 169 ? 67.759  75.535  74.425  1.00 89.47 ? 169 TYR B CE2 1 
ATOM 2264 C CZ  . TYR B 1 169 ? 67.184  76.091  73.263  1.00 91.12 ? 169 TYR B CZ  1 
ATOM 2265 O OH  . TYR B 1 169 ? 66.359  77.176  73.362  1.00 89.18 ? 169 TYR B OH  1 
ATOM 2266 N N   . ALA B 1 170 ? 70.445  69.957  71.415  1.00 94.47 ? 170 ALA B N   1 
ATOM 2267 C CA  . ALA B 1 170 ? 71.586  69.175  70.977  1.00 94.66 ? 170 ALA B CA  1 
ATOM 2268 C C   . ALA B 1 170 ? 72.230  69.797  69.729  1.00 94.14 ? 170 ALA B C   1 
ATOM 2269 O O   . ALA B 1 170 ? 71.572  70.481  68.939  1.00 93.00 ? 170 ALA B O   1 
ATOM 2270 C CB  . ALA B 1 170 ? 71.153  67.729  70.732  1.00 94.50 ? 170 ALA B CB  1 
ATOM 2271 N N   . ALA B 1 171 ? 73.518  69.552  69.529  1.00 93.09 ? 171 ALA B N   1 
ATOM 2272 C CA  . ALA B 1 171 ? 74.206  69.960  68.312  1.00 92.45 ? 171 ALA B CA  1 
ATOM 2273 C C   . ALA B 1 171 ? 73.867  69.015  67.143  1.00 91.94 ? 171 ALA B C   1 
ATOM 2274 O O   . ALA B 1 171 ? 73.695  67.812  67.361  1.00 91.03 ? 171 ALA B O   1 
ATOM 2275 C CB  . ALA B 1 171 ? 75.716  69.972  68.569  1.00 91.60 ? 171 ALA B CB  1 
ATOM 2276 N N   . PRO B 1 172 ? 73.895  69.501  65.896  1.00 88.96 ? 172 PRO B N   1 
ATOM 2277 C CA  . PRO B 1 172 ? 73.835  68.648  64.707  1.00 87.02 ? 172 PRO B CA  1 
ATOM 2278 C C   . PRO B 1 172 ? 74.831  67.480  64.753  1.00 86.90 ? 172 PRO B C   1 
ATOM 2279 O O   . PRO B 1 172 ? 74.472  66.342  64.493  1.00 85.88 ? 172 PRO B O   1 
ATOM 2280 C CB  . PRO B 1 172 ? 74.135  69.587  63.535  1.00 84.87 ? 172 PRO B CB  1 
ATOM 2281 C CG  . PRO B 1 172 ? 73.637  70.936  64.027  1.00 83.29 ? 172 PRO B CG  1 
ATOM 2282 C CD  . PRO B 1 172 ? 73.934  70.909  65.519  1.00 85.70 ? 172 PRO B CD  1 
ATOM 2283 N N   . SER B 1 173 ? 76.061  67.737  65.185  1.00 86.61 ? 173 SER B N   1 
ATOM 2284 C CA  . SER B 1 173 ? 77.112  66.710  65.295  1.00 85.86 ? 173 SER B CA  1 
ATOM 2285 C C   . SER B 1 173 ? 76.810  65.612  66.325  1.00 86.37 ? 173 SER B C   1 
ATOM 2286 O O   . SER B 1 173 ? 77.349  64.509  66.214  1.00 85.34 ? 173 SER B O   1 
ATOM 2287 C CB  . SER B 1 173 ? 78.448  67.377  65.638  1.00 84.18 ? 173 SER B CB  1 
ATOM 2288 O OG  . SER B 1 173 ? 78.411  67.959  66.928  1.00 80.57 ? 173 SER B OG  1 
ATOM 2289 N N   . TYR B 1 174 ? 75.982  65.890  67.332  1.00 90.96 ? 174 TYR B N   1 
ATOM 2290 C CA  . TYR B 1 174 ? 75.484  64.893  68.275  1.00 92.14 ? 174 TYR B CA  1 
ATOM 2291 C C   . TYR B 1 174 ? 74.359  64.060  67.650  1.00 91.39 ? 174 TYR B C   1 
ATOM 2292 O O   . TYR B 1 174 ? 74.461  62.836  67.616  1.00 89.67 ? 174 TYR B O   1 
ATOM 2293 C CB  . TYR B 1 174 ? 75.039  65.575  69.577  1.00 93.18 ? 174 TYR B CB  1 
ATOM 2294 C CG  . TYR B 1 174 ? 74.482  64.590  70.582  1.00 94.46 ? 174 TYR B CG  1 
ATOM 2295 C CD1 . TYR B 1 174 ? 73.108  64.258  70.569  1.00 92.81 ? 174 TYR B CD1 1 
ATOM 2296 C CD2 . TYR B 1 174 ? 75.339  63.949  71.497  1.00 92.92 ? 174 TYR B CD2 1 
ATOM 2297 C CE1 . TYR B 1 174 ? 72.610  63.283  71.442  1.00 93.57 ? 174 TYR B CE1 1 
ATOM 2298 C CE2 . TYR B 1 174 ? 74.844  62.971  72.374  1.00 93.35 ? 174 TYR B CE2 1 
ATOM 2299 C CZ  . TYR B 1 174 ? 73.483  62.635  72.338  1.00 95.29 ? 174 TYR B CZ  1 
ATOM 2300 O OH  . TYR B 1 174 ? 73.006  61.656  73.167  1.00 95.06 ? 174 TYR B OH  1 
ATOM 2301 N N   . ILE B 1 175 ? 73.342  64.725  67.099  1.00 90.49 ? 175 ILE B N   1 
ATOM 2302 C CA  . ILE B 1 175 ? 72.183  64.088  66.465  1.00 89.39 ? 175 ILE B CA  1 
ATOM 2303 C C   . ILE B 1 175 ? 72.613  63.173  65.309  1.00 88.07 ? 175 ILE B C   1 
ATOM 2304 O O   . ILE B 1 175 ? 72.201  62.016  65.261  1.00 86.21 ? 175 ILE B O   1 
ATOM 2305 C CB  . ILE B 1 175 ? 71.159  65.147  66.012  1.00 88.90 ? 175 ILE B CB  1 
ATOM 2306 C CG1 . ILE B 1 175 ? 70.608  65.975  67.206  1.00 86.46 ? 175 ILE B CG1 1 
ATOM 2307 C CG2 . ILE B 1 175 ? 70.003  64.524  65.219  1.00 86.05 ? 175 ILE B CG2 1 
ATOM 2308 C CD1 . ILE B 1 175 ? 69.865  65.179  68.278  1.00 79.47 ? 175 ILE B CD1 1 
ATOM 2309 N N   . ASN B 1 176 ? 73.528  63.637  64.466  1.00 85.72 ? 176 ASN B N   1 
ATOM 2310 C CA  . ASN B 1 176 ? 74.077  62.855  63.354  1.00 82.82 ? 176 ASN B CA  1 
ATOM 2311 C C   . ASN B 1 176 ? 74.734  61.533  63.798  1.00 82.88 ? 176 ASN B C   1 
ATOM 2312 O O   . ASN B 1 176 ? 74.878  60.623  62.989  1.00 81.23 ? 176 ASN B O   1 
ATOM 2313 C CB  . ASN B 1 176 ? 75.110  63.710  62.600  1.00 80.11 ? 176 ASN B CB  1 
ATOM 2314 C CG  . ASN B 1 176 ? 74.537  64.903  61.837  1.00 77.64 ? 176 ASN B CG  1 
ATOM 2315 O OD1 . ASN B 1 176 ? 73.352  65.036  61.595  1.00 71.87 ? 176 ASN B OD1 1 
ATOM 2316 N ND2 . ASN B 1 176 ? 75.391  65.814  61.402  1.00 70.87 ? 176 ASN B ND2 1 
ATOM 2317 N N   . ARG B 1 177 ? 75.162  61.426  65.048  1.00 85.52 ? 177 ARG B N   1 
ATOM 2318 C CA  . ARG B 1 177 ? 75.844  60.233  65.599  1.00 85.07 ? 177 ARG B CA  1 
ATOM 2319 C C   . ARG B 1 177 ? 74.964  59.386  66.503  1.00 86.00 ? 177 ARG B C   1 
ATOM 2320 O O   . ARG B 1 177 ? 75.161  58.173  66.550  1.00 84.20 ? 177 ARG B O   1 
ATOM 2321 C CB  . ARG B 1 177 ? 77.106  60.658  66.369  1.00 82.50 ? 177 ARG B CB  1 
ATOM 2322 C CG  . ARG B 1 177 ? 78.285  60.968  65.436  1.00 74.92 ? 177 ARG B CG  1 
ATOM 2323 C CD  . ARG B 1 177 ? 79.561  61.269  66.241  1.00 72.48 ? 177 ARG B CD  1 
ATOM 2324 N NE  . ARG B 1 177 ? 79.437  62.537  66.981  1.00 63.97 ? 177 ARG B NE  1 
ATOM 2325 C CZ  . ARG B 1 177 ? 80.235  62.971  67.940  1.00 57.58 ? 177 ARG B CZ  1 
ATOM 2326 N NH1 . ARG B 1 177 ? 81.272  62.279  68.349  1.00 52.61 ? 177 ARG B NH1 1 
ATOM 2327 N NH2 . ARG B 1 177 ? 80.012  64.125  68.508  1.00 49.52 ? 177 ARG B NH2 1 
ATOM 2328 N N   . HIS B 1 178 ? 74.065  60.006  67.249  1.00 90.58 ? 178 HIS B N   1 
ATOM 2329 C CA  . HIS B 1 178 ? 73.311  59.353  68.320  1.00 91.19 ? 178 HIS B CA  1 
ATOM 2330 C C   . HIS B 1 178 ? 71.798  59.309  68.074  1.00 91.24 ? 178 HIS B C   1 
ATOM 2331 O O   . HIS B 1 178 ? 71.085  58.644  68.824  1.00 88.52 ? 178 HIS B O   1 
ATOM 2332 C CB  . HIS B 1 178 ? 73.640  60.037  69.653  1.00 91.10 ? 178 HIS B CB  1 
ATOM 2333 C CG  . HIS B 1 178 ? 75.091  59.884  70.054  1.00 91.13 ? 178 HIS B CG  1 
ATOM 2334 N ND1 . HIS B 1 178 ? 75.649  58.735  70.576  1.00 79.60 ? 178 HIS B ND1 1 
ATOM 2335 C CD2 . HIS B 1 178 ? 76.102  60.814  69.950  1.00 79.40 ? 178 HIS B CD2 1 
ATOM 2336 C CE1 . HIS B 1 178 ? 76.958  58.966  70.785  1.00 82.41 ? 178 HIS B CE1 1 
ATOM 2337 N NE2 . HIS B 1 178 ? 77.268  60.222  70.416  1.00 84.61 ? 178 HIS B NE2 1 
ATOM 2338 N N   . GLY B 1 179 ? 71.313  59.961  67.021  1.00 89.39 ? 179 GLY B N   1 
ATOM 2339 C CA  . GLY B 1 179 ? 69.883  60.120  66.766  1.00 89.85 ? 179 GLY B CA  1 
ATOM 2340 C C   . GLY B 1 179 ? 69.243  61.180  67.661  1.00 91.41 ? 179 GLY B C   1 
ATOM 2341 O O   . GLY B 1 179 ? 69.872  61.739  68.562  1.00 90.70 ? 179 GLY B O   1 
ATOM 2342 N N   . GLU B 1 180 ? 67.960  61.446  67.415  1.00 91.24 ? 180 GLU B N   1 
ATOM 2343 C CA  . GLU B 1 180 ? 67.169  62.421  68.165  1.00 91.26 ? 180 GLU B CA  1 
ATOM 2344 C C   . GLU B 1 180 ? 66.213  61.708  69.133  1.00 91.97 ? 180 GLU B C   1 
ATOM 2345 O O   . GLU B 1 180 ? 65.419  60.871  68.699  1.00 90.65 ? 180 GLU B O   1 
ATOM 2346 C CB  . GLU B 1 180 ? 66.416  63.329  67.177  1.00 88.58 ? 180 GLU B CB  1 
ATOM 2347 C CG  . GLU B 1 180 ? 65.691  64.473  67.897  1.00 81.07 ? 180 GLU B CG  1 
ATOM 2348 C CD  . GLU B 1 180 ? 64.981  65.464  66.959  1.00 80.27 ? 180 GLU B CD  1 
ATOM 2349 O OE1 . GLU B 1 180 ? 64.291  66.350  67.512  1.00 72.90 ? 180 GLU B OE1 1 
ATOM 2350 O OE2 . GLU B 1 180 ? 65.124  65.344  65.734  1.00 74.12 ? 180 GLU B OE2 1 
ATOM 2351 N N   . PRO B 1 181 ? 66.251  62.017  70.442  1.00 93.64 ? 181 PRO B N   1 
ATOM 2352 C CA  . PRO B 1 181 ? 65.270  61.499  71.387  1.00 93.87 ? 181 PRO B CA  1 
ATOM 2353 C C   . PRO B 1 181 ? 63.891  62.110  71.107  1.00 93.27 ? 181 PRO B C   1 
ATOM 2354 O O   . PRO B 1 181 ? 63.754  63.324  70.916  1.00 91.10 ? 181 PRO B O   1 
ATOM 2355 C CB  . PRO B 1 181 ? 65.798  61.881  72.768  1.00 93.37 ? 181 PRO B CB  1 
ATOM 2356 C CG  . PRO B 1 181 ? 66.578  63.166  72.508  1.00 92.00 ? 181 PRO B CG  1 
ATOM 2357 C CD  . PRO B 1 181 ? 67.153  62.949  71.101  1.00 93.71 ? 181 PRO B CD  1 
ATOM 2358 N N   . GLN B 1 182 ? 62.855  61.265  71.143  1.00 91.53 ? 182 GLN B N   1 
ATOM 2359 C CA  . GLN B 1 182 ? 61.468  61.678  70.888  1.00 89.86 ? 182 GLN B CA  1 
ATOM 2360 C C   . GLN B 1 182 ? 60.662  61.922  72.169  1.00 89.84 ? 182 GLN B C   1 
ATOM 2361 O O   . GLN B 1 182 ? 59.577  62.498  72.131  1.00 86.22 ? 182 GLN B O   1 
ATOM 2362 C CB  . GLN B 1 182 ? 60.788  60.601  70.017  1.00 87.38 ? 182 GLN B CB  1 
ATOM 2363 C CG  . GLN B 1 182 ? 61.487  60.387  68.653  1.00 83.75 ? 182 GLN B CG  1 
ATOM 2364 C CD  . GLN B 1 182 ? 61.408  61.629  67.756  1.00 76.81 ? 182 GLN B CD  1 
ATOM 2365 O OE1 . GLN B 1 182 ? 60.343  62.141  67.482  1.00 67.81 ? 182 GLN B OE1 1 
ATOM 2366 N NE2 . GLN B 1 182 ? 62.527  62.142  67.303  1.00 65.88 ? 182 GLN B NE2 1 
ATOM 2367 N N   . SER B 1 183 ? 61.179  61.480  73.324  1.00 92.44 ? 183 SER B N   1 
ATOM 2368 C CA  . SER B 1 183 ? 60.514  61.585  74.626  1.00 92.96 ? 183 SER B CA  1 
ATOM 2369 C C   . SER B 1 183 ? 61.519  61.794  75.759  1.00 93.85 ? 183 SER B C   1 
ATOM 2370 O O   . SER B 1 183 ? 62.726  61.639  75.588  1.00 93.20 ? 183 SER B O   1 
ATOM 2371 C CB  . SER B 1 183 ? 59.673  60.329  74.865  1.00 91.33 ? 183 SER B CB  1 
ATOM 2372 O OG  . SER B 1 183 ? 60.507  59.204  75.096  1.00 87.41 ? 183 SER B OG  1 
ATOM 2373 N N   . VAL B 1 184 ? 61.016  62.105  76.946  1.00 93.74 ? 184 VAL B N   1 
ATOM 2374 C CA  . VAL B 1 184 ? 61.846  62.172  78.158  1.00 94.26 ? 184 VAL B CA  1 
ATOM 2375 C C   . VAL B 1 184 ? 62.458  60.801  78.490  1.00 94.55 ? 184 VAL B C   1 
ATOM 2376 O O   . VAL B 1 184 ? 63.600  60.738  78.923  1.00 93.15 ? 184 VAL B O   1 
ATOM 2377 C CB  . VAL B 1 184 ? 61.023  62.707  79.342  1.00 93.00 ? 184 VAL B CB  1 
ATOM 2378 C CG1 . VAL B 1 184 ? 61.759  62.591  80.683  1.00 87.38 ? 184 VAL B CG1 1 
ATOM 2379 C CG2 . VAL B 1 184 ? 60.675  64.182  79.127  1.00 87.34 ? 184 VAL B CG2 1 
ATOM 2380 N N   . GLU B 1 185 ? 61.729  59.716  78.251  1.00 93.74 ? 185 GLU B N   1 
ATOM 2381 C CA  . GLU B 1 185 ? 62.221  58.356  78.523  1.00 93.35 ? 185 GLU B CA  1 
ATOM 2382 C C   . GLU B 1 185 ? 63.377  57.955  77.592  1.00 93.97 ? 185 GLU B C   1 
ATOM 2383 O O   . GLU B 1 185 ? 64.302  57.280  78.032  1.00 92.37 ? 185 GLU B O   1 
ATOM 2384 C CB  . GLU B 1 185 ? 61.046  57.371  78.436  1.00 91.96 ? 185 GLU B CB  1 
ATOM 2385 C CG  . GLU B 1 185 ? 60.137  57.493  79.666  1.00 80.12 ? 185 GLU B CG  1 
ATOM 2386 C CD  . GLU B 1 185 ? 58.648  57.195  79.429  1.00 70.37 ? 185 GLU B CD  1 
ATOM 2387 O OE1 . GLU B 1 185 ? 57.975  56.876  80.438  1.00 61.23 ? 185 GLU B OE1 1 
ATOM 2388 O OE2 . GLU B 1 185 ? 58.182  57.365  78.285  1.00 60.98 ? 185 GLU B OE2 1 
ATOM 2389 N N   . ASP B 1 186 ? 63.388  58.450  76.347  1.00 94.29 ? 186 ASP B N   1 
ATOM 2390 C CA  . ASP B 1 186 ? 64.484  58.202  75.419  1.00 94.26 ? 186 ASP B CA  1 
ATOM 2391 C C   . ASP B 1 186 ? 65.824  58.785  75.901  1.00 94.98 ? 186 ASP B C   1 
ATOM 2392 O O   . ASP B 1 186 ? 66.881  58.282  75.518  1.00 93.75 ? 186 ASP B O   1 
ATOM 2393 C CB  . ASP B 1 186 ? 64.157  58.769  74.034  1.00 92.70 ? 186 ASP B CB  1 
ATOM 2394 C CG  . ASP B 1 186 ? 63.000  58.069  73.322  1.00 90.29 ? 186 ASP B CG  1 
ATOM 2395 O OD1 . ASP B 1 186 ? 62.819  56.853  73.524  1.00 84.99 ? 186 ASP B OD1 1 
ATOM 2396 O OD2 . ASP B 1 186 ? 62.312  58.781  72.549  1.00 85.47 ? 186 ASP B OD2 1 
ATOM 2397 N N   . LEU B 1 187 ? 65.804  59.777  76.794  1.00 95.12 ? 187 LEU B N   1 
ATOM 2398 C CA  . LEU B 1 187 ? 67.017  60.334  77.404  1.00 95.35 ? 187 LEU B CA  1 
ATOM 2399 C C   . LEU B 1 187 ? 67.849  59.277  78.143  1.00 95.47 ? 187 LEU B C   1 
ATOM 2400 O O   . LEU B 1 187 ? 69.049  59.476  78.329  1.00 94.31 ? 187 LEU B O   1 
ATOM 2401 C CB  . LEU B 1 187 ? 66.662  61.462  78.380  1.00 95.02 ? 187 LEU B CB  1 
ATOM 2402 C CG  . LEU B 1 187 ? 66.023  62.715  77.761  1.00 94.54 ? 187 LEU B CG  1 
ATOM 2403 C CD1 . LEU B 1 187 ? 65.605  63.674  78.882  1.00 92.11 ? 187 LEU B CD1 1 
ATOM 2404 C CD2 . LEU B 1 187 ? 66.995  63.454  76.849  1.00 91.56 ? 187 LEU B CD2 1 
ATOM 2405 N N   . ASP B 1 188 ? 67.253  58.163  78.530  1.00 95.26 ? 188 ASP B N   1 
ATOM 2406 C CA  . ASP B 1 188 ? 67.964  57.059  79.187  1.00 94.47 ? 188 ASP B CA  1 
ATOM 2407 C C   . ASP B 1 188 ? 68.995  56.390  78.268  1.00 94.16 ? 188 ASP B C   1 
ATOM 2408 O O   . ASP B 1 188 ? 69.966  55.805  78.744  1.00 91.00 ? 188 ASP B O   1 
ATOM 2409 C CB  . ASP B 1 188 ? 66.946  56.024  79.702  1.00 92.96 ? 188 ASP B CB  1 
ATOM 2410 C CG  . ASP B 1 188 ? 66.135  56.508  80.907  1.00 91.32 ? 188 ASP B CG  1 
ATOM 2411 O OD1 . ASP B 1 188 ? 66.240  57.694  81.294  1.00 86.15 ? 188 ASP B OD1 1 
ATOM 2412 O OD2 . ASP B 1 188 ? 65.479  55.680  81.564  1.00 85.78 ? 188 ASP B OD2 1 
ATOM 2413 N N   . ASN B 1 189 ? 68.833  56.532  76.944  1.00 94.51 ? 189 ASN B N   1 
ATOM 2414 C CA  . ASN B 1 189 ? 69.759  56.034  75.925  1.00 93.89 ? 189 ASN B CA  1 
ATOM 2415 C C   . ASN B 1 189 ? 70.700  57.116  75.385  1.00 94.05 ? 189 ASN B C   1 
ATOM 2416 O O   . ASN B 1 189 ? 71.488  56.858  74.471  1.00 91.01 ? 189 ASN B O   1 
ATOM 2417 C CB  . ASN B 1 189 ? 68.938  55.387  74.802  1.00 92.29 ? 189 ASN B CB  1 
ATOM 2418 C CG  . ASN B 1 189 ? 68.092  54.228  75.302  1.00 88.26 ? 189 ASN B CG  1 
ATOM 2419 O OD1 . ASN B 1 189 ? 68.561  53.328  75.986  1.00 79.14 ? 189 ASN B OD1 1 
ATOM 2420 N ND2 . ASN B 1 189 ? 66.818  54.218  74.966  1.00 76.48 ? 189 ASN B ND2 1 
ATOM 2421 N N   . HIS B 1 190 ? 70.628  58.314  75.934  1.00 95.88 ? 190 HIS B N   1 
ATOM 2422 C CA  . HIS B 1 190 ? 71.383  59.469  75.462  1.00 96.23 ? 190 HIS B CA  1 
ATOM 2423 C C   . HIS B 1 190 ? 72.404  59.977  76.482  1.00 96.33 ? 190 HIS B C   1 
ATOM 2424 O O   . HIS B 1 190 ? 72.377  59.650  77.672  1.00 94.93 ? 190 HIS B O   1 
ATOM 2425 C CB  . HIS B 1 190 ? 70.406  60.561  75.019  1.00 95.85 ? 190 HIS B CB  1 
ATOM 2426 C CG  . HIS B 1 190 ? 69.855  60.291  73.641  1.00 96.40 ? 190 HIS B CG  1 
ATOM 2427 N ND1 . HIS B 1 190 ? 70.447  60.676  72.452  1.00 89.14 ? 190 HIS B ND1 1 
ATOM 2428 C CD2 . HIS B 1 190 ? 68.720  59.595  73.322  1.00 89.10 ? 190 HIS B CD2 1 
ATOM 2429 C CE1 . HIS B 1 190 ? 69.680  60.231  71.444  1.00 90.88 ? 190 HIS B CE1 1 
ATOM 2430 N NE2 . HIS B 1 190 ? 68.630  59.567  71.938  1.00 91.79 ? 190 HIS B NE2 1 
ATOM 2431 N N   . ARG B 1 191 ? 73.328  60.804  76.013  1.00 96.64 ? 191 ARG B N   1 
ATOM 2432 C CA  . ARG B 1 191 ? 74.316  61.484  76.853  1.00 96.65 ? 191 ARG B CA  1 
ATOM 2433 C C   . ARG B 1 191 ? 73.752  62.840  77.257  1.00 96.88 ? 191 ARG B C   1 
ATOM 2434 O O   . ARG B 1 191 ? 73.502  63.676  76.399  1.00 95.88 ? 191 ARG B O   1 
ATOM 2435 C CB  . ARG B 1 191 ? 75.638  61.629  76.100  1.00 95.44 ? 191 ARG B CB  1 
ATOM 2436 C CG  . ARG B 1 191 ? 76.282  60.265  75.790  1.00 92.88 ? 191 ARG B CG  1 
ATOM 2437 C CD  . ARG B 1 191 ? 77.570  60.475  74.986  1.00 89.61 ? 191 ARG B CD  1 
ATOM 2438 N NE  . ARG B 1 191 ? 78.221  59.196  74.677  1.00 84.45 ? 191 ARG B NE  1 
ATOM 2439 C CZ  . ARG B 1 191 ? 79.381  59.045  74.057  1.00 78.98 ? 191 ARG B CZ  1 
ATOM 2440 N NH1 . ARG B 1 191 ? 80.073  60.073  73.623  1.00 74.10 ? 191 ARG B NH1 1 
ATOM 2441 N NH2 . ARG B 1 191 ? 79.864  57.865  73.871  1.00 74.55 ? 191 ARG B NH2 1 
ATOM 2442 N N   . ILE B 1 192 ? 73.592  63.057  78.547  1.00 96.99 ? 192 ILE B N   1 
ATOM 2443 C CA  . ILE B 1 192 ? 73.107  64.334  79.070  1.00 96.83 ? 192 ILE B CA  1 
ATOM 2444 C C   . ILE B 1 192 ? 74.246  65.164  79.677  1.00 97.28 ? 192 ILE B C   1 
ATOM 2445 O O   . ILE B 1 192 ? 75.190  64.629  80.266  1.00 96.20 ? 192 ILE B O   1 
ATOM 2446 C CB  . ILE B 1 192 ? 71.908  64.160  80.021  1.00 94.81 ? 192 ILE B CB  1 
ATOM 2447 C CG1 . ILE B 1 192 ? 72.257  63.364  81.291  1.00 86.54 ? 192 ILE B CG1 1 
ATOM 2448 C CG2 . ILE B 1 192 ? 70.732  63.504  79.253  1.00 81.73 ? 192 ILE B CG2 1 
ATOM 2449 C CD1 . ILE B 1 192 ? 71.138  63.349  82.340  1.00 79.81 ? 192 ILE B CD1 1 
ATOM 2450 N N   . ILE B 1 193 ? 74.140  66.471  79.521  1.00 96.81 ? 193 ILE B N   1 
ATOM 2451 C CA  . ILE B 1 193 ? 75.015  67.482  80.114  1.00 96.94 ? 193 ILE B CA  1 
ATOM 2452 C C   . ILE B 1 193 ? 74.167  68.301  81.090  1.00 96.32 ? 193 ILE B C   1 
ATOM 2453 O O   . ILE B 1 193 ? 73.100  68.789  80.720  1.00 95.46 ? 193 ILE B O   1 
ATOM 2454 C CB  . ILE B 1 193 ? 75.649  68.390  79.045  1.00 96.98 ? 193 ILE B CB  1 
ATOM 2455 C CG1 . ILE B 1 193 ? 76.306  67.594  77.895  1.00 94.39 ? 193 ILE B CG1 1 
ATOM 2456 C CG2 . ILE B 1 193 ? 76.686  69.329  79.703  1.00 93.65 ? 193 ILE B CG2 1 
ATOM 2457 C CD1 . ILE B 1 193 ? 76.715  68.471  76.705  1.00 93.91 ? 193 ILE B CD1 1 
ATOM 2458 N N   . SER B 1 194 ? 74.639  68.468  82.310  1.00 96.51 ? 194 SER B N   1 
ATOM 2459 C CA  . SER B 1 194 ? 73.939  69.218  83.352  1.00 96.12 ? 194 SER B CA  1 
ATOM 2460 C C   . SER B 1 194 ? 74.892  70.125  84.133  1.00 96.42 ? 194 SER B C   1 
ATOM 2461 O O   . SER B 1 194 ? 76.099  70.183  83.861  1.00 94.61 ? 194 SER B O   1 
ATOM 2462 C CB  . SER B 1 194 ? 73.162  68.241  84.245  1.00 93.52 ? 194 SER B CB  1 
ATOM 2463 O OG  . SER B 1 194 ? 74.054  67.355  84.881  1.00 84.42 ? 194 SER B OG  1 
ATOM 2464 N N   . PHE B 1 195 ? 74.342  70.882  85.076  1.00 95.40 ? 195 PHE B N   1 
ATOM 2465 C CA  . PHE B 1 195 ? 75.125  71.832  85.869  1.00 95.27 ? 195 PHE B CA  1 
ATOM 2466 C C   . PHE B 1 195 ? 75.887  71.127  87.003  1.00 94.73 ? 195 PHE B C   1 
ATOM 2467 O O   . PHE B 1 195 ? 77.040  71.440  87.273  1.00 91.47 ? 195 PHE B O   1 
ATOM 2468 C CB  . PHE B 1 195 ? 74.165  72.906  86.396  1.00 94.49 ? 195 PHE B CB  1 
ATOM 2469 C CG  . PHE B 1 195 ? 74.840  74.135  86.963  1.00 95.42 ? 195 PHE B CG  1 
ATOM 2470 C CD1 . PHE B 1 195 ? 75.211  74.178  88.320  1.00 91.97 ? 195 PHE B CD1 1 
ATOM 2471 C CD2 . PHE B 1 195 ? 75.050  75.265  86.152  1.00 91.78 ? 195 PHE B CD2 1 
ATOM 2472 C CE1 . PHE B 1 195 ? 75.779  75.338  88.862  1.00 91.32 ? 195 PHE B CE1 1 
ATOM 2473 C CE2 . PHE B 1 195 ? 75.614  76.432  86.690  1.00 90.80 ? 195 PHE B CE2 1 
ATOM 2474 C CZ  . PHE B 1 195 ? 75.981  76.467  88.042  1.00 93.51 ? 195 PHE B CZ  1 
ATOM 2475 N N   . GLY B 1 196 ? 75.251  70.146  87.625  1.00 93.71 ? 196 GLY B N   1 
ATOM 2476 C CA  . GLY B 1 196 ? 75.741  69.466  88.807  1.00 92.87 ? 196 GLY B CA  1 
ATOM 2477 C C   . GLY B 1 196 ? 75.382  70.173  90.113  1.00 92.66 ? 196 GLY B C   1 
ATOM 2478 O O   . GLY B 1 196 ? 74.744  71.226  90.125  1.00 89.67 ? 196 GLY B O   1 
ATOM 2479 N N   . GLU B 1 197 ? 75.808  69.572  91.219  1.00 91.42 ? 197 GLU B N   1 
ATOM 2480 C CA  . GLU B 1 197 ? 75.682  70.143  92.557  1.00 89.05 ? 197 GLU B CA  1 
ATOM 2481 C C   . GLU B 1 197 ? 77.062  70.570  93.099  1.00 87.18 ? 197 GLU B C   1 
ATOM 2482 O O   . GLU B 1 197 ? 78.070  69.932  92.787  1.00 81.22 ? 197 GLU B O   1 
ATOM 2483 C CB  . GLU B 1 197 ? 74.986  69.153  93.507  1.00 86.70 ? 197 GLU B CB  1 
ATOM 2484 C CG  . GLU B 1 197 ? 73.522  68.841  93.138  1.00 82.77 ? 197 GLU B CG  1 
ATOM 2485 C CD  . GLU B 1 197 ? 72.579  70.059  93.174  1.00 79.93 ? 197 GLU B CD  1 
ATOM 2486 O OE1 . GLU B 1 197 ? 71.506  69.970  92.543  1.00 70.33 ? 197 GLU B OE1 1 
ATOM 2487 O OE2 . GLU B 1 197 ? 72.913  71.073  93.825  1.00 71.96 ? 197 GLU B OE2 1 
ATOM 2488 N N   . PRO B 1 198 ? 77.146  71.638  93.932  1.00 84.45 ? 198 PRO B N   1 
ATOM 2489 C CA  . PRO B 1 198 ? 76.031  72.469  94.361  1.00 83.68 ? 198 PRO B CA  1 
ATOM 2490 C C   . PRO B 1 198 ? 75.555  73.431  93.254  1.00 85.30 ? 198 PRO B C   1 
ATOM 2491 O O   . PRO B 1 198 ? 76.364  74.024  92.549  1.00 81.88 ? 198 PRO B O   1 
ATOM 2492 C CB  . PRO B 1 198 ? 76.550  73.229  95.588  1.00 79.60 ? 198 PRO B CB  1 
ATOM 2493 C CG  . PRO B 1 198 ? 78.045  73.394  95.284  1.00 77.66 ? 198 PRO B CG  1 
ATOM 2494 C CD  . PRO B 1 198 ? 78.383  72.105  94.531  1.00 80.51 ? 198 PRO B CD  1 
ATOM 2495 N N   . ALA B 1 199 ? 74.240  73.606  93.143  1.00 86.67 ? 199 ALA B N   1 
ATOM 2496 C CA  . ALA B 1 199 ? 73.628  74.648  92.335  1.00 87.55 ? 199 ALA B CA  1 
ATOM 2497 C C   . ALA B 1 199 ? 72.979  75.707  93.238  1.00 87.56 ? 199 ALA B C   1 
ATOM 2498 O O   . ALA B 1 199 ? 72.435  75.363  94.290  1.00 84.22 ? 199 ALA B O   1 
ATOM 2499 C CB  . ALA B 1 199 ? 72.621  74.015  91.366  1.00 85.99 ? 199 ALA B CB  1 
ATOM 2500 N N   . PRO B 1 200 ? 72.981  76.999  92.856  1.00 86.14 ? 200 PRO B N   1 
ATOM 2501 C CA  . PRO B 1 200 ? 72.299  78.037  93.617  1.00 84.55 ? 200 PRO B CA  1 
ATOM 2502 C C   . PRO B 1 200 ? 70.789  77.781  93.685  1.00 84.87 ? 200 PRO B C   1 
ATOM 2503 O O   . PRO B 1 200 ? 70.156  77.452  92.682  1.00 82.13 ? 200 PRO B O   1 
ATOM 2504 C CB  . PRO B 1 200 ? 72.612  79.354  92.902  1.00 81.95 ? 200 PRO B CB  1 
ATOM 2505 C CG  . PRO B 1 200 ? 73.867  79.044  92.087  1.00 79.02 ? 200 PRO B CG  1 
ATOM 2506 C CD  . PRO B 1 200 ? 73.698  77.566  91.737  1.00 82.20 ? 200 PRO B CD  1 
ATOM 2507 N N   . ASN B 1 201 ? 70.196  78.014  94.839  1.00 83.13 ? 201 ASN B N   1 
ATOM 2508 C CA  . ASN B 1 201 ? 68.784  77.707  95.101  1.00 81.65 ? 201 ASN B CA  1 
ATOM 2509 C C   . ASN B 1 201 ? 67.776  78.426  94.179  1.00 82.89 ? 201 ASN B C   1 
ATOM 2510 O O   . ASN B 1 201 ? 66.617  78.016  94.092  1.00 78.04 ? 201 ASN B O   1 
ATOM 2511 C CB  . ASN B 1 201 ? 68.465  78.069  96.563  1.00 76.59 ? 201 ASN B CB  1 
ATOM 2512 C CG  . ASN B 1 201 ? 69.151  77.158  97.577  1.00 68.38 ? 201 ASN B CG  1 
ATOM 2513 O OD1 . ASN B 1 201 ? 69.504  76.036  97.316  1.00 59.23 ? 201 ASN B OD1 1 
ATOM 2514 N ND2 . ASN B 1 201 ? 69.320  77.638  98.789  1.00 60.00 ? 201 ASN B ND2 1 
ATOM 2515 N N   . TYR B 1 202 ? 68.172  79.521  93.560  1.00 82.52 ? 202 TYR B N   1 
ATOM 2516 C CA  . TYR B 1 202 ? 67.330  80.287  92.632  1.00 81.40 ? 202 TYR B CA  1 
ATOM 2517 C C   . TYR B 1 202 ? 67.563  79.921  91.157  1.00 81.95 ? 202 TYR B C   1 
ATOM 2518 O O   . TYR B 1 202 ? 66.789  80.348  90.303  1.00 78.64 ? 202 TYR B O   1 
ATOM 2519 C CB  . TYR B 1 202 ? 67.557  81.782  92.859  1.00 79.13 ? 202 TYR B CB  1 
ATOM 2520 C CG  . TYR B 1 202 ? 68.955  82.226  92.513  1.00 77.95 ? 202 TYR B CG  1 
ATOM 2521 C CD1 . TYR B 1 202 ? 69.935  82.334  93.518  1.00 71.72 ? 202 TYR B CD1 1 
ATOM 2522 C CD2 . TYR B 1 202 ? 69.304  82.492  91.174  1.00 74.27 ? 202 TYR B CD2 1 
ATOM 2523 C CE1 . TYR B 1 202 ? 71.251  82.675  93.183  1.00 69.07 ? 202 TYR B CE1 1 
ATOM 2524 C CE2 . TYR B 1 202 ? 70.618  82.827  90.828  1.00 69.98 ? 202 TYR B CE2 1 
ATOM 2525 C CZ  . TYR B 1 202 ? 71.589  82.908  91.841  1.00 72.39 ? 202 TYR B CZ  1 
ATOM 2526 O OH  . TYR B 1 202 ? 72.869  83.203  91.505  1.00 69.67 ? 202 TYR B OH  1 
ATOM 2527 N N   . LEU B 1 203 ? 68.608  79.173  90.850  1.00 82.93 ? 203 LEU B N   1 
ATOM 2528 C CA  . LEU B 1 203 ? 68.896  78.629  89.530  1.00 81.65 ? 203 LEU B CA  1 
ATOM 2529 C C   . LEU B 1 203 ? 68.066  77.360  89.343  1.00 81.98 ? 203 LEU B C   1 
ATOM 2530 O O   . LEU B 1 203 ? 68.495  76.245  89.637  1.00 78.36 ? 203 LEU B O   1 
ATOM 2531 C CB  . LEU B 1 203 ? 70.415  78.419  89.381  1.00 78.63 ? 203 LEU B CB  1 
ATOM 2532 C CG  . LEU B 1 203 ? 71.050  79.371  88.353  1.00 74.75 ? 203 LEU B CG  1 
ATOM 2533 C CD1 . LEU B 1 203 ? 72.531  79.607  88.683  1.00 70.31 ? 203 LEU B CD1 1 
ATOM 2534 C CD2 . LEU B 1 203 ? 70.986  78.808  86.939  1.00 70.32 ? 203 LEU B CD2 1 
ATOM 2535 N N   . LEU B 1 204 ? 66.829  77.561  88.896  1.00 80.24 ? 204 LEU B N   1 
ATOM 2536 C CA  . LEU B 1 204 ? 65.855  76.499  88.727  1.00 78.03 ? 204 LEU B CA  1 
ATOM 2537 C C   . LEU B 1 204 ? 66.216  75.613  87.537  1.00 80.18 ? 204 LEU B C   1 
ATOM 2538 O O   . LEU B 1 204 ? 66.681  76.098  86.506  1.00 73.05 ? 204 LEU B O   1 
ATOM 2539 C CB  . LEU B 1 204 ? 64.451  77.129  88.576  1.00 70.66 ? 204 LEU B CB  1 
ATOM 2540 C CG  . LEU B 1 204 ? 63.952  77.836  89.844  1.00 64.09 ? 204 LEU B CG  1 
ATOM 2541 C CD1 . LEU B 1 204 ? 62.800  78.786  89.518  1.00 58.09 ? 204 LEU B CD1 1 
ATOM 2542 C CD2 . LEU B 1 204 ? 63.442  76.827  90.892  1.00 57.67 ? 204 LEU B CD2 1 
ATOM 2543 N N   . ASP B 1 205 ? 65.976  74.320  87.688  1.00 85.35 ? 205 ASP B N   1 
ATOM 2544 C CA  . ASP B 1 205 ? 65.969  73.321  86.610  1.00 86.63 ? 205 ASP B CA  1 
ATOM 2545 C C   . ASP B 1 205 ? 67.288  73.151  85.820  1.00 88.76 ? 205 ASP B C   1 
ATOM 2546 O O   . ASP B 1 205 ? 67.313  72.511  84.772  1.00 85.57 ? 205 ASP B O   1 
ATOM 2547 C CB  . ASP B 1 205 ? 64.735  73.522  85.726  1.00 82.77 ? 205 ASP B CB  1 
ATOM 2548 C CG  . ASP B 1 205 ? 63.458  73.442  86.562  1.00 80.07 ? 205 ASP B CG  1 
ATOM 2549 O OD1 . ASP B 1 205 ? 63.249  72.383  87.203  1.00 73.08 ? 205 ASP B OD1 1 
ATOM 2550 O OD2 . ASP B 1 205 ? 62.705  74.445  86.609  1.00 74.17 ? 205 ASP B OD2 1 
ATOM 2551 N N   . VAL B 1 206 ? 68.414  73.628  86.349  1.00 89.53 ? 206 VAL B N   1 
ATOM 2552 C CA  . VAL B 1 206 ? 69.736  73.436  85.716  1.00 89.33 ? 206 VAL B CA  1 
ATOM 2553 C C   . VAL B 1 206 ? 70.180  71.972  85.652  1.00 90.74 ? 206 VAL B C   1 
ATOM 2554 O O   . VAL B 1 206 ? 71.055  71.632  84.852  1.00 88.89 ? 206 VAL B O   1 
ATOM 2555 C CB  . VAL B 1 206 ? 70.824  74.276  86.405  1.00 87.06 ? 206 VAL B CB  1 
ATOM 2556 C CG1 . VAL B 1 206 ? 70.552  75.762  86.216  1.00 81.18 ? 206 VAL B CG1 1 
ATOM 2557 C CG2 . VAL B 1 206 ? 70.977  73.976  87.906  1.00 80.99 ? 206 VAL B CG2 1 
ATOM 2558 N N   . ASN B 1 207 ? 69.563  71.102  86.458  1.00 93.02 ? 207 ASN B N   1 
ATOM 2559 C CA  . ASN B 1 207 ? 69.736  69.652  86.447  1.00 93.22 ? 207 ASN B CA  1 
ATOM 2560 C C   . ASN B 1 207 ? 68.453  68.916  86.006  1.00 93.52 ? 207 ASN B C   1 
ATOM 2561 O O   . ASN B 1 207 ? 68.295  67.729  86.289  1.00 91.63 ? 207 ASN B O   1 
ATOM 2562 C CB  . ASN B 1 207 ? 70.243  69.189  87.820  1.00 92.32 ? 207 ASN B CB  1 
ATOM 2563 C CG  . ASN B 1 207 ? 71.621  69.733  88.166  1.00 92.88 ? 207 ASN B CG  1 
ATOM 2564 O OD1 . ASN B 1 207 ? 72.525  69.802  87.349  1.00 87.07 ? 207 ASN B OD1 1 
ATOM 2565 N ND2 . ASN B 1 207 ? 71.819  70.123  89.403  1.00 85.58 ? 207 ASN B ND2 1 
ATOM 2566 N N   . TRP B 1 208 ? 67.546  69.595  85.297  1.00 93.60 ? 208 TRP B N   1 
ATOM 2567 C CA  . TRP B 1 208 ? 66.259  69.033  84.880  1.00 93.54 ? 208 TRP B CA  1 
ATOM 2568 C C   . TRP B 1 208 ? 66.395  67.698  84.130  1.00 93.83 ? 208 TRP B C   1 
ATOM 2569 O O   . TRP B 1 208 ? 65.647  66.761  84.401  1.00 92.71 ? 208 TRP B O   1 
ATOM 2570 C CB  . TRP B 1 208 ? 65.519  70.058  84.015  1.00 93.07 ? 208 TRP B CB  1 
ATOM 2571 C CG  . TRP B 1 208 ? 64.163  69.613  83.555  1.00 92.65 ? 208 TRP B CG  1 
ATOM 2572 C CD1 . TRP B 1 208 ? 63.009  69.774  84.241  1.00 88.81 ? 208 TRP B CD1 1 
ATOM 2573 C CD2 . TRP B 1 208 ? 63.804  68.926  82.321  1.00 91.80 ? 208 TRP B CD2 1 
ATOM 2574 N NE1 . TRP B 1 208 ? 61.953  69.237  83.512  1.00 87.76 ? 208 TRP B NE1 1 
ATOM 2575 C CE2 . TRP B 1 208 ? 62.404  68.703  82.325  1.00 90.50 ? 208 TRP B CE2 1 
ATOM 2576 C CE3 . TRP B 1 208 ? 64.539  68.474  81.197  1.00 88.89 ? 208 TRP B CE3 1 
ATOM 2577 C CZ2 . TRP B 1 208 ? 61.743  68.060  81.254  1.00 89.23 ? 208 TRP B CZ2 1 
ATOM 2578 C CZ3 . TRP B 1 208 ? 63.881  67.827  80.131  1.00 86.50 ? 208 TRP B CZ3 1 
ATOM 2579 C CH2 . TRP B 1 208 ? 62.498  67.624  80.167  1.00 86.85 ? 208 TRP B CH2 1 
ATOM 2580 N N   . LEU B 1 209 ? 67.384  67.582  83.248  1.00 94.55 ? 209 LEU B N   1 
ATOM 2581 C CA  . LEU B 1 209 ? 67.640  66.363  82.472  1.00 94.85 ? 209 LEU B CA  1 
ATOM 2582 C C   . LEU B 1 209 ? 67.989  65.145  83.342  1.00 94.85 ? 209 LEU B C   1 
ATOM 2583 O O   . LEU B 1 209 ? 67.743  64.010  82.928  1.00 93.53 ? 209 LEU B O   1 
ATOM 2584 C CB  . LEU B 1 209 ? 68.780  66.622  81.479  1.00 94.66 ? 209 LEU B CB  1 
ATOM 2585 C CG  . LEU B 1 209 ? 68.421  67.573  80.326  1.00 94.69 ? 209 LEU B CG  1 
ATOM 2586 C CD1 . LEU B 1 209 ? 69.693  67.940  79.567  1.00 92.46 ? 209 LEU B CD1 1 
ATOM 2587 C CD2 . LEU B 1 209 ? 67.454  66.927  79.333  1.00 92.17 ? 209 LEU B CD2 1 
ATOM 2588 N N   . GLU B 1 210 ? 68.561  65.346  84.530  1.00 94.67 ? 210 GLU B N   1 
ATOM 2589 C CA  . GLU B 1 210 ? 68.863  64.251  85.465  1.00 94.00 ? 210 GLU B CA  1 
ATOM 2590 C C   . GLU B 1 210 ? 67.590  63.717  86.137  1.00 93.55 ? 210 GLU B C   1 
ATOM 2591 O O   . GLU B 1 210 ? 67.491  62.515  86.405  1.00 91.25 ? 210 GLU B O   1 
ATOM 2592 C CB  . GLU B 1 210 ? 69.865  64.716  86.533  1.00 93.45 ? 210 GLU B CB  1 
ATOM 2593 C CG  . GLU B 1 210 ? 71.245  65.084  85.960  1.00 92.81 ? 210 GLU B CG  1 
ATOM 2594 C CD  . GLU B 1 210 ? 72.260  65.491  87.041  1.00 93.14 ? 210 GLU B CD  1 
ATOM 2595 O OE1 . GLU B 1 210 ? 73.160  66.307  86.734  1.00 86.76 ? 210 GLU B OE1 1 
ATOM 2596 O OE2 . GLU B 1 210 ? 72.183  64.973  88.174  1.00 88.78 ? 210 GLU B OE2 1 
ATOM 2597 N N   . ASN B 1 211 ? 66.620  64.597  86.373  1.00 93.22 ? 211 ASN B N   1 
ATOM 2598 C CA  . ASN B 1 211 ? 65.446  64.341  87.199  1.00 92.05 ? 211 ASN B CA  1 
ATOM 2599 C C   . ASN B 1 211 ? 64.168  64.061  86.397  1.00 92.10 ? 211 ASN B C   1 
ATOM 2600 O O   . ASN B 1 211 ? 63.244  63.421  86.906  1.00 88.56 ? 211 ASN B O   1 
ATOM 2601 C CB  . ASN B 1 211 ? 65.255  65.562  88.121  1.00 89.37 ? 211 ASN B CB  1 
ATOM 2602 C CG  . ASN B 1 211 ? 66.453  65.798  89.027  1.00 85.71 ? 211 ASN B CG  1 
ATOM 2603 O OD1 . ASN B 1 211 ? 66.950  64.914  89.687  1.00 75.47 ? 211 ASN B OD1 1 
ATOM 2604 N ND2 . ASN B 1 211 ? 66.934  67.025  89.090  1.00 74.90 ? 211 ASN B ND2 1 
ATOM 2605 N N   . ALA B 1 212 ? 64.092  64.533  85.131  1.00 91.84 ? 212 ALA B N   1 
ATOM 2606 C CA  . ALA B 1 212 ? 62.905  64.450  84.301  1.00 91.63 ? 212 ALA B CA  1 
ATOM 2607 C C   . ALA B 1 212 ? 62.410  62.996  84.153  1.00 91.43 ? 212 ALA B C   1 
ATOM 2608 O O   . ALA B 1 212 ? 63.136  62.125  83.686  1.00 88.92 ? 212 ALA B O   1 
ATOM 2609 C CB  . ALA B 1 212 ? 63.202  65.087  82.943  1.00 90.88 ? 212 ALA B CB  1 
ATOM 2610 N N   . GLY B 1 213 ? 61.165  62.756  84.560  1.00 89.59 ? 213 GLY B N   1 
ATOM 2611 C CA  . GLY B 1 213 ? 60.542  61.424  84.521  1.00 88.64 ? 213 GLY B CA  1 
ATOM 2612 C C   . GLY B 1 213 ? 61.115  60.403  85.512  1.00 89.51 ? 213 GLY B C   1 
ATOM 2613 O O   . GLY B 1 213 ? 60.752  59.230  85.438  1.00 85.07 ? 213 GLY B O   1 
ATOM 2614 N N   . ARG B 1 214 ? 62.003  60.816  86.421  1.00 89.40 ? 214 ARG B N   1 
ATOM 2615 C CA  . ARG B 1 214 ? 62.608  59.927  87.420  1.00 89.83 ? 214 ARG B CA  1 
ATOM 2616 C C   . ARG B 1 214 ? 62.312  60.374  88.853  1.00 89.60 ? 214 ARG B C   1 
ATOM 2617 O O   . ARG B 1 214 ? 61.986  61.531  89.115  1.00 84.45 ? 214 ARG B O   1 
ATOM 2618 C CB  . ARG B 1 214 ? 64.115  59.783  87.178  1.00 87.48 ? 214 ARG B CB  1 
ATOM 2619 C CG  . ARG B 1 214 ? 64.425  59.073  85.850  1.00 85.30 ? 214 ARG B CG  1 
ATOM 2620 C CD  . ARG B 1 214 ? 65.880  58.609  85.858  1.00 83.13 ? 214 ARG B CD  1 
ATOM 2621 N NE  . ARG B 1 214 ? 66.237  57.771  84.708  1.00 81.69 ? 214 ARG B NE  1 
ATOM 2622 C CZ  . ARG B 1 214 ? 67.211  56.883  84.686  1.00 82.16 ? 214 ARG B CZ  1 
ATOM 2623 N NH1 . ARG B 1 214 ? 67.965  56.652  85.722  1.00 73.93 ? 214 ARG B NH1 1 
ATOM 2624 N NH2 . ARG B 1 214 ? 67.468  56.202  83.618  1.00 75.95 ? 214 ARG B NH2 1 
ATOM 2625 N N   . SER B 1 215 ? 62.433  59.421  89.779  1.00 88.05 ? 215 SER B N   1 
ATOM 2626 C CA  . SER B 1 215 ? 62.381  59.720  91.206  1.00 87.65 ? 215 SER B CA  1 
ATOM 2627 C C   . SER B 1 215 ? 63.713  60.318  91.681  1.00 87.73 ? 215 SER B C   1 
ATOM 2628 O O   . SER B 1 215 ? 64.765  60.084  91.085  1.00 83.21 ? 215 SER B O   1 
ATOM 2629 C CB  . SER B 1 215 ? 62.013  58.470  92.008  1.00 84.26 ? 215 SER B CB  1 
ATOM 2630 O OG  . SER B 1 215 ? 62.914  57.421  91.769  1.00 76.90 ? 215 SER B OG  1 
ATOM 2631 N N   . SER B 1 216 ? 63.671  61.075  92.776  1.00 85.55 ? 216 SER B N   1 
ATOM 2632 C CA  . SER B 1 216 ? 64.839  61.779  93.321  1.00 84.20 ? 216 SER B CA  1 
ATOM 2633 C C   . SER B 1 216 ? 65.995  60.864  93.752  1.00 85.29 ? 216 SER B C   1 
ATOM 2634 O O   . SER B 1 216 ? 67.131  61.308  93.825  1.00 79.67 ? 216 SER B O   1 
ATOM 2635 C CB  . SER B 1 216 ? 64.401  62.623  94.520  1.00 79.66 ? 216 SER B CB  1 
ATOM 2636 O OG  . SER B 1 216 ? 63.709  61.831  95.472  1.00 69.55 ? 216 SER B OG  1 
ATOM 2637 N N   . ASP B 1 217 ? 65.701  59.605  94.011  1.00 84.41 ? 217 ASP B N   1 
ATOM 2638 C CA  . ASP B 1 217 ? 66.644  58.556  94.400  1.00 84.01 ? 217 ASP B CA  1 
ATOM 2639 C C   . ASP B 1 217 ? 67.154  57.715  93.217  1.00 85.92 ? 217 ASP B C   1 
ATOM 2640 O O   . ASP B 1 217 ? 68.053  56.893  93.388  1.00 79.82 ? 217 ASP B O   1 
ATOM 2641 C CB  . ASP B 1 217 ? 65.983  57.679  95.483  1.00 79.33 ? 217 ASP B CB  1 
ATOM 2642 C CG  . ASP B 1 217 ? 64.650  57.033  95.072  1.00 69.79 ? 217 ASP B CG  1 
ATOM 2643 O OD1 . ASP B 1 217 ? 63.883  57.644  94.290  1.00 60.61 ? 217 ASP B OD1 1 
ATOM 2644 O OD2 . ASP B 1 217 ? 64.351  55.934  95.591  1.00 62.12 ? 217 ASP B OD2 1 
ATOM 2645 N N   . ASN B 1 218 ? 66.618  57.939  92.016  1.00 88.43 ? 218 ASN B N   1 
ATOM 2646 C CA  . ASN B 1 218 ? 67.002  57.229  90.798  1.00 89.41 ? 218 ASN B CA  1 
ATOM 2647 C C   . ASN B 1 218 ? 67.176  58.188  89.612  1.00 90.80 ? 218 ASN B C   1 
ATOM 2648 O O   . ASN B 1 218 ? 66.585  58.011  88.541  1.00 86.82 ? 218 ASN B O   1 
ATOM 2649 C CB  . ASN B 1 218 ? 65.982  56.105  90.538  1.00 85.05 ? 218 ASN B CB  1 
ATOM 2650 C CG  . ASN B 1 218 ? 66.406  55.197  89.402  1.00 78.60 ? 218 ASN B CG  1 
ATOM 2651 O OD1 . ASN B 1 218 ? 67.571  54.958  89.131  1.00 69.68 ? 218 ASN B OD1 1 
ATOM 2652 N ND2 . ASN B 1 218 ? 65.447  54.621  88.697  1.00 69.19 ? 218 ASN B ND2 1 
ATOM 2653 N N   . THR B 1 219 ? 67.994  59.219  89.783  1.00 91.13 ? 219 THR B N   1 
ATOM 2654 C CA  . THR B 1 219 ? 68.307  60.204  88.750  1.00 91.35 ? 219 THR B CA  1 
ATOM 2655 C C   . THR B 1 219 ? 69.161  59.613  87.626  1.00 92.28 ? 219 THR B C   1 
ATOM 2656 O O   . THR B 1 219 ? 69.833  58.591  87.797  1.00 89.27 ? 219 THR B O   1 
ATOM 2657 C CB  . THR B 1 219 ? 68.979  61.437  89.358  1.00 88.13 ? 219 THR B CB  1 
ATOM 2658 O OG1 . THR B 1 219 ? 70.154  61.066  90.053  1.00 78.51 ? 219 THR B OG1 1 
ATOM 2659 C CG2 . THR B 1 219 ? 68.068  62.147  90.355  1.00 77.14 ? 219 THR B CG2 1 
ATOM 2660 N N   . ARG B 1 220 ? 69.149  60.236  86.446  1.00 92.72 ? 220 ARG B N   1 
ATOM 2661 C CA  . ARG B 1 220 ? 70.050  59.875  85.343  1.00 93.14 ? 220 ARG B CA  1 
ATOM 2662 C C   . ARG B 1 220 ? 71.489  60.239  85.679  1.00 93.47 ? 220 ARG B C   1 
ATOM 2663 O O   . ARG B 1 220 ? 71.746  61.279  86.279  1.00 91.81 ? 220 ARG B O   1 
ATOM 2664 C CB  . ARG B 1 220 ? 69.636  60.553  84.027  1.00 92.11 ? 220 ARG B CB  1 
ATOM 2665 C CG  . ARG B 1 220 ? 68.310  60.007  83.489  1.00 89.76 ? 220 ARG B CG  1 
ATOM 2666 C CD  . ARG B 1 220 ? 67.934  60.622  82.147  1.00 89.86 ? 220 ARG B CD  1 
ATOM 2667 N NE  . ARG B 1 220 ? 66.599  60.154  81.760  1.00 89.34 ? 220 ARG B NE  1 
ATOM 2668 C CZ  . ARG B 1 220 ? 65.440  60.702  82.123  1.00 91.72 ? 220 ARG B CZ  1 
ATOM 2669 N NH1 . ARG B 1 220 ? 65.370  61.842  82.768  1.00 81.54 ? 220 ARG B NH1 1 
ATOM 2670 N NH2 . ARG B 1 220 ? 64.332  60.095  81.844  1.00 85.54 ? 220 ARG B NH2 1 
ATOM 2671 N N   . ILE B 1 221 ? 72.419  59.403  85.244  1.00 93.54 ? 221 ILE B N   1 
ATOM 2672 C CA  . ILE B 1 221 ? 73.851  59.699  85.374  1.00 92.81 ? 221 ILE B CA  1 
ATOM 2673 C C   . ILE B 1 221 ? 74.248  60.617  84.207  1.00 93.79 ? 221 ILE B C   1 
ATOM 2674 O O   . ILE B 1 221 ? 74.220  60.172  83.058  1.00 92.10 ? 221 ILE B O   1 
ATOM 2675 C CB  . ILE B 1 221 ? 74.690  58.409  85.425  1.00 90.17 ? 221 ILE B CB  1 
ATOM 2676 C CG1 . ILE B 1 221 ? 74.243  57.522  86.608  1.00 84.68 ? 221 ILE B CG1 1 
ATOM 2677 C CG2 . ILE B 1 221 ? 76.184  58.765  85.547  1.00 82.29 ? 221 ILE B CG2 1 
ATOM 2678 C CD1 . ILE B 1 221 ? 74.961  56.154  86.685  1.00 73.37 ? 221 ILE B CD1 1 
ATOM 2679 N N   . PRO B 1 222 ? 74.625  61.867  84.462  1.00 94.78 ? 222 PRO B N   1 
ATOM 2680 C CA  . PRO B 1 222 ? 75.068  62.766  83.412  1.00 95.00 ? 222 PRO B CA  1 
ATOM 2681 C C   . PRO B 1 222 ? 76.434  62.335  82.869  1.00 95.32 ? 222 PRO B C   1 
ATOM 2682 O O   . PRO B 1 222 ? 77.305  61.894  83.614  1.00 93.69 ? 222 PRO B O   1 
ATOM 2683 C CB  . PRO B 1 222 ? 75.103  64.154  84.053  1.00 93.65 ? 222 PRO B CB  1 
ATOM 2684 C CG  . PRO B 1 222 ? 75.419  63.839  85.514  1.00 90.79 ? 222 PRO B CG  1 
ATOM 2685 C CD  . PRO B 1 222 ? 74.680  62.524  85.757  1.00 93.43 ? 222 PRO B CD  1 
ATOM 2686 N N   . HIS B 1 223 ? 76.624  62.506  81.558  1.00 94.83 ? 223 HIS B N   1 
ATOM 2687 C CA  . HIS B 1 223 ? 77.912  62.256  80.920  1.00 95.39 ? 223 HIS B CA  1 
ATOM 2688 C C   . HIS B 1 223 ? 78.926  63.362  81.252  1.00 95.79 ? 223 HIS B C   1 
ATOM 2689 O O   . HIS B 1 223 ? 80.121  63.110  81.385  1.00 94.00 ? 223 HIS B O   1 
ATOM 2690 C CB  . HIS B 1 223 ? 77.690  62.111  79.410  1.00 94.17 ? 223 HIS B CB  1 
ATOM 2691 C CG  . HIS B 1 223 ? 78.884  61.515  78.709  1.00 93.64 ? 223 HIS B CG  1 
ATOM 2692 N ND1 . HIS B 1 223 ? 79.569  60.379  79.117  1.00 85.26 ? 223 HIS B ND1 1 
ATOM 2693 C CD2 . HIS B 1 223 ? 79.467  61.946  77.549  1.00 85.16 ? 223 HIS B CD2 1 
ATOM 2694 C CE1 . HIS B 1 223 ? 80.538  60.147  78.219  1.00 87.67 ? 223 HIS B CE1 1 
ATOM 2695 N NE2 . HIS B 1 223 ? 80.504  61.069  77.253  1.00 89.16 ? 223 HIS B NE2 1 
ATOM 2696 N N   . LEU B 1 224 ? 78.423  64.582  81.393  1.00 95.25 ? 224 LEU B N   1 
ATOM 2697 C CA  . LEU B 1 224 ? 79.205  65.749  81.792  1.00 95.32 ? 224 LEU B CA  1 
ATOM 2698 C C   . LEU B 1 224 ? 78.378  66.645  82.713  1.00 95.63 ? 224 LEU B C   1 
ATOM 2699 O O   . LEU B 1 224 ? 77.212  66.914  82.441  1.00 95.14 ? 224 LEU B O   1 
ATOM 2700 C CB  . LEU B 1 224 ? 79.643  66.483  80.512  1.00 94.72 ? 224 LEU B CB  1 
ATOM 2701 C CG  . LEU B 1 224 ? 80.429  67.787  80.724  1.00 93.41 ? 224 LEU B CG  1 
ATOM 2702 C CD1 . LEU B 1 224 ? 81.730  67.575  81.494  1.00 89.02 ? 224 LEU B CD1 1 
ATOM 2703 C CD2 . LEU B 1 224 ? 80.783  68.380  79.359  1.00 89.21 ? 224 LEU B CD2 1 
ATOM 2704 N N   . GLN B 1 225 ? 79.016  67.147  83.757  1.00 95.23 ? 225 GLN B N   1 
ATOM 2705 C CA  . GLN B 1 225 ? 78.487  68.241  84.564  1.00 94.98 ? 225 GLN B CA  1 
ATOM 2706 C C   . GLN B 1 225 ? 79.469  69.413  84.551  1.00 94.47 ? 225 GLN B C   1 
ATOM 2707 O O   . GLN B 1 225 ? 80.678  69.204  84.687  1.00 93.98 ? 225 GLN B O   1 
ATOM 2708 C CB  . GLN B 1 225 ? 78.228  67.775  86.005  1.00 94.11 ? 225 GLN B CB  1 
ATOM 2709 C CG  . GLN B 1 225 ? 77.055  66.797  86.128  1.00 92.86 ? 225 GLN B CG  1 
ATOM 2710 C CD  . GLN B 1 225 ? 76.908  66.247  87.549  1.00 93.87 ? 225 GLN B CD  1 
ATOM 2711 O OE1 . GLN B 1 225 ? 77.876  65.985  88.248  1.00 86.53 ? 225 GLN B OE1 1 
ATOM 2712 N NE2 . GLN B 1 225 ? 75.700  66.031  88.010  1.00 85.67 ? 225 GLN B NE2 1 
ATOM 2713 N N   . ILE B 1 226 ? 78.968  70.624  84.405  1.00 95.21 ? 226 ILE B N   1 
ATOM 2714 C CA  . ILE B 1 226 ? 79.767  71.846  84.505  1.00 95.49 ? 226 ILE B CA  1 
ATOM 2715 C C   . ILE B 1 226 ? 78.918  72.933  85.167  1.00 94.77 ? 226 ILE B C   1 
ATOM 2716 O O   . ILE B 1 226 ? 77.878  73.323  84.628  1.00 94.01 ? 226 ILE B O   1 
ATOM 2717 C CB  . ILE B 1 226 ? 80.268  72.353  83.126  1.00 95.35 ? 226 ILE B CB  1 
ATOM 2718 C CG1 . ILE B 1 226 ? 80.871  71.243  82.239  1.00 87.93 ? 226 ILE B CG1 1 
ATOM 2719 C CG2 . ILE B 1 226 ? 81.330  73.453  83.362  1.00 86.26 ? 226 ILE B CG2 1 
ATOM 2720 C CD1 . ILE B 1 226 ? 81.313  71.718  80.852  1.00 87.34 ? 226 ILE B CD1 1 
ATOM 2721 N N   . ASN B 1 227 ? 79.375  73.479  86.277  1.00 95.23 ? 227 ASN B N   1 
ATOM 2722 C CA  . ASN B 1 227 ? 78.711  74.575  86.989  1.00 93.83 ? 227 ASN B CA  1 
ATOM 2723 C C   . ASN B 1 227 ? 78.869  75.937  86.276  1.00 93.88 ? 227 ASN B C   1 
ATOM 2724 O O   . ASN B 1 227 ? 79.178  76.961  86.897  1.00 91.61 ? 227 ASN B O   1 
ATOM 2725 C CB  . ASN B 1 227 ? 79.178  74.586  88.456  1.00 91.93 ? 227 ASN B CB  1 
ATOM 2726 C CG  . ASN B 1 227 ? 80.648  74.923  88.612  1.00 92.34 ? 227 ASN B CG  1 
ATOM 2727 O OD1 . ASN B 1 227 ? 81.468  74.669  87.755  1.00 87.85 ? 227 ASN B OD1 1 
ATOM 2728 N ND2 . ASN B 1 227 ? 81.017  75.485  89.745  1.00 85.46 ? 227 ASN B ND2 1 
ATOM 2729 N N   . SER B 1 228 ? 78.707  75.954  84.958  1.00 94.46 ? 228 SER B N   1 
ATOM 2730 C CA  . SER B 1 228 ? 78.786  77.143  84.118  1.00 94.89 ? 228 SER B CA  1 
ATOM 2731 C C   . SER B 1 228 ? 77.897  76.979  82.887  1.00 95.03 ? 228 SER B C   1 
ATOM 2732 O O   . SER B 1 228 ? 78.199  76.176  82.001  1.00 94.50 ? 228 SER B O   1 
ATOM 2733 C CB  . SER B 1 228 ? 80.241  77.368  83.690  1.00 93.96 ? 228 SER B CB  1 
ATOM 2734 O OG  . SER B 1 228 ? 80.320  78.331  82.662  1.00 91.81 ? 228 SER B OG  1 
ATOM 2735 N N   . GLN B 1 229 ? 76.843  77.779  82.796  1.00 95.28 ? 229 GLN B N   1 
ATOM 2736 C CA  . GLN B 1 229 ? 75.880  77.718  81.693  1.00 95.08 ? 229 GLN B CA  1 
ATOM 2737 C C   . GLN B 1 229 ? 76.533  77.933  80.316  1.00 95.69 ? 229 GLN B C   1 
ATOM 2738 O O   . GLN B 1 229 ? 76.205  77.239  79.353  1.00 94.79 ? 229 GLN B O   1 
ATOM 2739 C CB  . GLN B 1 229 ? 74.778  78.769  81.928  1.00 93.60 ? 229 GLN B CB  1 
ATOM 2740 C CG  . GLN B 1 229 ? 73.859  78.473  83.129  1.00 89.18 ? 229 GLN B CG  1 
ATOM 2741 C CD  . GLN B 1 229 ? 72.884  77.316  82.890  1.00 84.41 ? 229 GLN B CD  1 
ATOM 2742 O OE1 . GLN B 1 229 ? 72.930  76.630  81.889  1.00 73.19 ? 229 GLN B OE1 1 
ATOM 2743 N NE2 . GLN B 1 229 ? 71.975  77.085  83.803  1.00 71.32 ? 229 GLN B NE2 1 
ATOM 2744 N N   . THR B 1 230 ? 77.493  78.844  80.206  1.00 94.94 ? 230 THR B N   1 
ATOM 2745 C CA  . THR B 1 230 ? 78.222  79.092  78.952  1.00 94.87 ? 230 THR B CA  1 
ATOM 2746 C C   . THR B 1 230 ? 79.095  77.902  78.549  1.00 95.52 ? 230 THR B C   1 
ATOM 2747 O O   . THR B 1 230 ? 79.181  77.579  77.368  1.00 94.88 ? 230 THR B O   1 
ATOM 2748 C CB  . THR B 1 230 ? 79.084  80.354  79.047  1.00 93.94 ? 230 THR B CB  1 
ATOM 2749 O OG1 . THR B 1 230 ? 79.905  80.284  80.187  1.00 87.07 ? 230 THR B OG1 1 
ATOM 2750 C CG2 . THR B 1 230 ? 78.223  81.611  79.158  1.00 85.72 ? 230 THR B CG2 1 
ATOM 2751 N N   . SER B 1 231 ? 79.685  77.208  79.518  1.00 94.83 ? 231 SER B N   1 
ATOM 2752 C CA  . SER B 1 231 ? 80.456  75.987  79.267  1.00 95.55 ? 231 SER B CA  1 
ATOM 2753 C C   . SER B 1 231 ? 79.550  74.809  78.902  1.00 96.00 ? 231 SER B C   1 
ATOM 2754 O O   . SER B 1 231 ? 79.917  74.022  78.038  1.00 96.17 ? 231 SER B O   1 
ATOM 2755 C CB  . SER B 1 231 ? 81.321  75.632  80.467  1.00 95.56 ? 231 SER B CB  1 
ATOM 2756 O OG  . SER B 1 231 ? 82.289  76.646  80.678  1.00 91.56 ? 231 SER B OG  1 
ATOM 2757 N N   . ILE B 1 232 ? 78.353  74.705  79.489  1.00 96.44 ? 232 ILE B N   1 
ATOM 2758 C CA  . ILE B 1 232 ? 77.342  73.718  79.077  1.00 96.63 ? 232 ILE B CA  1 
ATOM 2759 C C   . ILE B 1 232 ? 76.940  73.961  77.615  1.00 96.42 ? 232 ILE B C   1 
ATOM 2760 O O   . ILE B 1 232 ? 76.956  73.023  76.823  1.00 95.83 ? 232 ILE B O   1 
ATOM 2761 C CB  . ILE B 1 232 ? 76.113  73.731  80.008  1.00 96.62 ? 232 ILE B CB  1 
ATOM 2762 C CG1 . ILE B 1 232 ? 76.498  73.253  81.428  1.00 95.32 ? 232 ILE B CG1 1 
ATOM 2763 C CG2 . ILE B 1 232 ? 74.988  72.823  79.455  1.00 94.97 ? 232 ILE B CG2 1 
ATOM 2764 C CD1 . ILE B 1 232 ? 75.410  73.523  82.479  1.00 93.08 ? 232 ILE B CD1 1 
ATOM 2765 N N   . LYS B 1 233 ? 76.668  75.212  77.222  1.00 96.72 ? 233 LYS B N   1 
ATOM 2766 C CA  . LYS B 1 233 ? 76.410  75.561  75.816  1.00 96.37 ? 233 LYS B CA  1 
ATOM 2767 C C   . LYS B 1 233 ? 77.567  75.136  74.916  1.00 96.17 ? 233 LYS B C   1 
ATOM 2768 O O   . LYS B 1 233 ? 77.336  74.528  73.874  1.00 95.51 ? 233 LYS B O   1 
ATOM 2769 C CB  . LYS B 1 233 ? 76.133  77.066  75.681  1.00 95.48 ? 233 LYS B CB  1 
ATOM 2770 C CG  . LYS B 1 233 ? 75.891  77.484  74.217  1.00 94.14 ? 233 LYS B CG  1 
ATOM 2771 C CD  . LYS B 1 233 ? 75.647  78.991  74.102  1.00 90.68 ? 233 LYS B CD  1 
ATOM 2772 C CE  . LYS B 1 233 ? 75.466  79.397  72.635  1.00 85.48 ? 233 LYS B CE  1 
ATOM 2773 N NZ  . LYS B 1 233 ? 75.068  80.828  72.500  1.00 79.81 ? 233 LYS B NZ  1 
ATOM 2774 N N   . ARG B 1 234 ? 78.806  75.426  75.311  1.00 95.78 ? 234 ARG B N   1 
ATOM 2775 C CA  . ARG B 1 234 ? 79.998  75.037  74.552  1.00 95.32 ? 234 ARG B CA  1 
ATOM 2776 C C   . ARG B 1 234 ? 80.107  73.522  74.410  1.00 95.36 ? 234 ARG B C   1 
ATOM 2777 O O   . ARG B 1 234 ? 80.308  73.038  73.302  1.00 94.70 ? 234 ARG B O   1 
ATOM 2778 C CB  . ARG B 1 234 ? 81.246  75.662  75.198  1.00 94.59 ? 234 ARG B CB  1 
ATOM 2779 C CG  . ARG B 1 234 ? 82.560  75.319  74.477  1.00 91.38 ? 234 ARG B CG  1 
ATOM 2780 C CD  . ARG B 1 234 ? 82.561  75.760  73.012  1.00 86.99 ? 234 ARG B CD  1 
ATOM 2781 N NE  . ARG B 1 234 ? 83.850  75.478  72.373  1.00 83.23 ? 234 ARG B NE  1 
ATOM 2782 C CZ  . ARG B 1 234 ? 84.144  75.576  71.088  1.00 78.09 ? 234 ARG B CZ  1 
ATOM 2783 N NH1 . ARG B 1 234 ? 83.275  75.997  70.212  1.00 70.81 ? 234 ARG B NH1 1 
ATOM 2784 N NH2 . ARG B 1 234 ? 85.326  75.241  70.683  1.00 73.04 ? 234 ARG B NH2 1 
ATOM 2785 N N   . ALA B 1 235 ? 79.918  72.786  75.484  1.00 96.02 ? 235 ALA B N   1 
ATOM 2786 C CA  . ALA B 1 235 ? 79.928  71.332  75.489  1.00 96.16 ? 235 ALA B CA  1 
ATOM 2787 C C   . ALA B 1 235 ? 78.818  70.734  74.606  1.00 96.21 ? 235 ALA B C   1 
ATOM 2788 O O   . ALA B 1 235 ? 79.052  69.766  73.881  1.00 95.74 ? 235 ALA B O   1 
ATOM 2789 C CB  . ALA B 1 235 ? 79.801  70.869  76.944  1.00 96.35 ? 235 ALA B CB  1 
ATOM 2790 N N   . CYS B 1 236 ? 77.637  71.341  74.615  1.00 96.11 ? 236 CYS B N   1 
ATOM 2791 C CA  . CYS B 1 236 ? 76.524  70.967  73.750  1.00 95.71 ? 236 CYS B CA  1 
ATOM 2792 C C   . CYS B 1 236 ? 76.867  71.200  72.265  1.00 95.16 ? 236 CYS B C   1 
ATOM 2793 O O   . CYS B 1 236 ? 76.740  70.284  71.455  1.00 94.08 ? 236 CYS B O   1 
ATOM 2794 C CB  . CYS B 1 236 ? 75.273  71.739  74.205  1.00 95.70 ? 236 CYS B CB  1 
ATOM 2795 S SG  . CYS B 1 236 ? 73.786  71.113  73.390  1.00 94.75 ? 236 CYS B SG  1 
ATOM 2796 N N   . LEU B 1 237 ? 77.405  72.380  71.918  1.00 94.42 ? 237 LEU B N   1 
ATOM 2797 C CA  . LEU B 1 237 ? 77.862  72.713  70.561  1.00 92.94 ? 237 LEU B CA  1 
ATOM 2798 C C   . LEU B 1 237 ? 78.960  71.769  70.053  1.00 92.20 ? 237 LEU B C   1 
ATOM 2799 O O   . LEU B 1 237 ? 78.981  71.427  68.875  1.00 91.17 ? 237 LEU B O   1 
ATOM 2800 C CB  . LEU B 1 237 ? 78.376  74.165  70.537  1.00 91.74 ? 237 LEU B CB  1 
ATOM 2801 C CG  . LEU B 1 237 ? 77.282  75.239  70.521  1.00 86.83 ? 237 LEU B CG  1 
ATOM 2802 C CD1 . LEU B 1 237 ? 77.899  76.609  70.798  1.00 83.44 ? 237 LEU B CD1 1 
ATOM 2803 C CD2 . LEU B 1 237 ? 76.578  75.306  69.163  1.00 83.97 ? 237 LEU B CD2 1 
ATOM 2804 N N   . LEU B 1 238 ? 79.838  71.316  70.940  1.00 93.30 ? 238 LEU B N   1 
ATOM 2805 C CA  . LEU B 1 238 ? 80.874  70.331  70.630  1.00 92.14 ? 238 LEU B CA  1 
ATOM 2806 C C   . LEU B 1 238 ? 80.324  68.902  70.438  1.00 91.72 ? 238 LEU B C   1 
ATOM 2807 O O   . LEU B 1 238 ? 81.092  67.984  70.126  1.00 90.35 ? 238 LEU B O   1 
ATOM 2808 C CB  . LEU B 1 238 ? 81.940  70.366  71.736  1.00 91.71 ? 238 LEU B CB  1 
ATOM 2809 C CG  . LEU B 1 238 ? 82.798  71.647  71.768  1.00 90.53 ? 238 LEU B CG  1 
ATOM 2810 C CD1 . LEU B 1 238 ? 83.629  71.669  73.062  1.00 87.38 ? 238 LEU B CD1 1 
ATOM 2811 C CD2 . LEU B 1 238 ? 83.752  71.731  70.575  1.00 87.05 ? 238 LEU B CD2 1 
ATOM 2812 N N   . GLY B 1 239 ? 79.023  68.697  70.617  1.00 92.90 ? 239 GLY B N   1 
ATOM 2813 C CA  . GLY B 1 239 ? 78.367  67.400  70.441  1.00 92.51 ? 239 GLY B CA  1 
ATOM 2814 C C   . GLY B 1 239 ? 78.665  66.388  71.543  1.00 93.21 ? 239 GLY B C   1 
ATOM 2815 O O   . GLY B 1 239 ? 78.653  65.185  71.284  1.00 91.97 ? 239 GLY B O   1 
ATOM 2816 N N   . ILE B 1 240 ? 78.946  66.843  72.765  1.00 95.01 ? 240 ILE B N   1 
ATOM 2817 C CA  . ILE B 1 240 ? 79.169  65.942  73.909  1.00 95.24 ? 240 ILE B CA  1 
ATOM 2818 C C   . ILE B 1 240 ? 77.864  65.268  74.345  1.00 95.19 ? 240 ILE B C   1 
ATOM 2819 O O   . ILE B 1 240 ? 77.875  64.111  74.760  1.00 93.98 ? 240 ILE B O   1 
ATOM 2820 C CB  . ILE B 1 240 ? 79.822  66.695  75.097  1.00 95.26 ? 240 ILE B CB  1 
ATOM 2821 C CG1 . ILE B 1 240 ? 81.195  67.276  74.684  1.00 93.72 ? 240 ILE B CG1 1 
ATOM 2822 C CG2 . ILE B 1 240 ? 79.982  65.772  76.322  1.00 93.10 ? 240 ILE B CG2 1 
ATOM 2823 C CD1 . ILE B 1 240 ? 81.904  68.081  75.778  1.00 90.57 ? 240 ILE B CD1 1 
ATOM 2824 N N   . GLY B 1 241 ? 76.748  65.986  74.261  1.00 96.21 ? 241 GLY B N   1 
ATOM 2825 C CA  . GLY B 1 241 ? 75.458  65.508  74.720  1.00 96.33 ? 241 GLY B CA  1 
ATOM 2826 C C   . GLY B 1 241 ? 74.346  66.539  74.594  1.00 96.73 ? 241 GLY B C   1 
ATOM 2827 O O   . GLY B 1 241 ? 74.507  67.606  74.002  1.00 95.85 ? 241 GLY B O   1 
ATOM 2828 N N   . ILE B 1 242 ? 73.211  66.166  75.179  1.00 97.49 ? 242 ILE B N   1 
ATOM 2829 C CA  . ILE B 1 242 ? 72.003  66.978  75.250  1.00 97.68 ? 242 ILE B CA  1 
ATOM 2830 C C   . ILE B 1 242 ? 72.081  67.875  76.488  1.00 97.67 ? 242 ILE B C   1 
ATOM 2831 O O   . ILE B 1 242 ? 72.484  67.427  77.557  1.00 97.01 ? 242 ILE B O   1 
ATOM 2832 C CB  . ILE B 1 242 ? 70.772  66.041  75.290  1.00 97.22 ? 242 ILE B CB  1 
ATOM 2833 C CG1 . ILE B 1 242 ? 70.715  65.177  74.006  1.00 95.38 ? 242 ILE B CG1 1 
ATOM 2834 C CG2 . ILE B 1 242 ? 69.476  66.839  75.457  1.00 95.39 ? 242 ILE B CG2 1 
ATOM 2835 C CD1 . ILE B 1 242 ? 69.702  64.030  74.093  1.00 92.22 ? 242 ILE B CD1 1 
ATOM 2836 N N   . ALA B 1 243 ? 71.678  69.138  76.347  1.00 97.33 ? 243 ALA B N   1 
ATOM 2837 C CA  . ALA B 1 243 ? 71.709  70.113  77.426  1.00 97.15 ? 243 ALA B CA  1 
ATOM 2838 C C   . ALA B 1 243 ? 70.360  70.825  77.593  1.00 96.80 ? 243 ALA B C   1 
ATOM 2839 O O   . ALA B 1 243 ? 69.694  71.133  76.613  1.00 95.95 ? 243 ALA B O   1 
ATOM 2840 C CB  . ALA B 1 243 ? 72.839  71.108  77.165  1.00 96.62 ? 243 ALA B CB  1 
ATOM 2841 N N   . CYS B 1 244 ? 69.994  71.138  78.825  1.00 96.43 ? 244 CYS B N   1 
ATOM 2842 C CA  . CYS B 1 244 ? 68.904  72.051  79.150  1.00 96.03 ? 244 CYS B CA  1 
ATOM 2843 C C   . CYS B 1 244 ? 69.493  73.442  79.422  1.00 95.89 ? 244 CYS B C   1 
ATOM 2844 O O   . CYS B 1 244 ? 70.336  73.594  80.308  1.00 94.69 ? 244 CYS B O   1 
ATOM 2845 C CB  . CYS B 1 244 ? 68.125  71.498  80.340  1.00 95.20 ? 244 CYS B CB  1 
ATOM 2846 S SG  . CYS B 1 244 ? 66.713  72.572  80.701  1.00 91.37 ? 244 CYS B SG  1 
ATOM 2847 N N   . LEU B 1 245 ? 69.081  74.443  78.653  1.00 95.15 ? 245 LEU B N   1 
ATOM 2848 C CA  . LEU B 1 245 ? 69.666  75.784  78.691  1.00 95.01 ? 245 LEU B CA  1 
ATOM 2849 C C   . LEU B 1 245 ? 68.583  76.865  78.644  1.00 94.60 ? 245 LEU B C   1 
ATOM 2850 O O   . LEU B 1 245 ? 67.596  76.713  77.923  1.00 93.68 ? 245 LEU B O   1 
ATOM 2851 C CB  . LEU B 1 245 ? 70.635  75.953  77.511  1.00 94.73 ? 245 LEU B CB  1 
ATOM 2852 C CG  . LEU B 1 245 ? 71.940  75.139  77.609  1.00 94.58 ? 245 LEU B CG  1 
ATOM 2853 C CD1 . LEU B 1 245 ? 72.693  75.216  76.285  1.00 92.37 ? 245 LEU B CD1 1 
ATOM 2854 C CD2 . LEU B 1 245 ? 72.857  75.675  78.714  1.00 92.06 ? 245 LEU B CD2 1 
ATOM 2855 N N   . PRO B 1 246 ? 68.793  77.986  79.344  1.00 94.18 ? 246 PRO B N   1 
ATOM 2856 C CA  . PRO B 1 246 ? 67.939  79.152  79.199  1.00 93.86 ? 246 PRO B CA  1 
ATOM 2857 C C   . PRO B 1 246 ? 68.197  79.866  77.867  1.00 93.68 ? 246 PRO B C   1 
ATOM 2858 O O   . PRO B 1 246 ? 69.318  79.893  77.355  1.00 92.44 ? 246 PRO B O   1 
ATOM 2859 C CB  . PRO B 1 246 ? 68.266  80.031  80.407  1.00 92.98 ? 246 PRO B CB  1 
ATOM 2860 C CG  . PRO B 1 246 ? 69.732  79.707  80.687  1.00 91.43 ? 246 PRO B CG  1 
ATOM 2861 C CD  . PRO B 1 246 ? 69.852  78.237  80.307  1.00 93.55 ? 246 PRO B CD  1 
ATOM 2862 N N   . ASP B 1 247 ? 67.142  80.501  77.346  1.00 91.81 ? 247 ASP B N   1 
ATOM 2863 C CA  . ASP B 1 247 ? 67.165  81.272  76.101  1.00 90.51 ? 247 ASP B CA  1 
ATOM 2864 C C   . ASP B 1 247 ? 68.272  82.350  76.056  1.00 91.05 ? 247 ASP B C   1 
ATOM 2865 O O   . ASP B 1 247 ? 68.943  82.491  75.032  1.00 88.09 ? 247 ASP B O   1 
ATOM 2866 C CB  . ASP B 1 247 ? 65.760  81.855  75.859  1.00 86.99 ? 247 ASP B CB  1 
ATOM 2867 C CG  . ASP B 1 247 ? 65.152  82.643  77.032  1.00 81.10 ? 247 ASP B CG  1 
ATOM 2868 O OD1 . ASP B 1 247 ? 65.860  82.891  78.037  1.00 72.44 ? 247 ASP B OD1 1 
ATOM 2869 O OD2 . ASP B 1 247 ? 63.953  82.992  76.944  1.00 75.84 ? 247 ASP B OD2 1 
ATOM 2870 N N   . TYR B 1 248 ? 68.547  83.045  77.180  1.00 92.05 ? 248 TYR B N   1 
ATOM 2871 C CA  . TYR B 1 248 ? 69.601  84.070  77.245  1.00 92.25 ? 248 TYR B CA  1 
ATOM 2872 C C   . TYR B 1 248 ? 71.031  83.524  77.085  1.00 92.44 ? 248 TYR B C   1 
ATOM 2873 O O   . TYR B 1 248 ? 71.951  84.293  76.786  1.00 91.04 ? 248 TYR B O   1 
ATOM 2874 C CB  . TYR B 1 248 ? 69.485  84.891  78.535  1.00 91.78 ? 248 TYR B CB  1 
ATOM 2875 C CG  . TYR B 1 248 ? 69.752  84.139  79.822  1.00 92.03 ? 248 TYR B CG  1 
ATOM 2876 C CD1 . TYR B 1 248 ? 68.688  83.785  80.671  1.00 89.19 ? 248 TYR B CD1 1 
ATOM 2877 C CD2 . TYR B 1 248 ? 71.071  83.788  80.204  1.00 89.28 ? 248 TYR B CD2 1 
ATOM 2878 C CE1 . TYR B 1 248 ? 68.924  83.078  81.850  1.00 87.88 ? 248 TYR B CE1 1 
ATOM 2879 C CE2 . TYR B 1 248 ? 71.314  83.069  81.386  1.00 86.95 ? 248 TYR B CE2 1 
ATOM 2880 C CZ  . TYR B 1 248 ? 70.236  82.712  82.209  1.00 89.45 ? 248 TYR B CZ  1 
ATOM 2881 O OH  . TYR B 1 248 ? 70.464  81.996  83.355  1.00 87.39 ? 248 TYR B OH  1 
ATOM 2882 N N   . ILE B 1 249 ? 71.236  82.235  77.272  1.00 93.50 ? 249 ILE B N   1 
ATOM 2883 C CA  . ILE B 1 249 ? 72.513  81.557  77.003  1.00 93.70 ? 249 ILE B CA  1 
ATOM 2884 C C   . ILE B 1 249 ? 72.573  81.108  75.545  1.00 93.04 ? 249 ILE B C   1 
ATOM 2885 O O   . ILE B 1 249 ? 73.598  81.276  74.877  1.00 90.89 ? 249 ILE B O   1 
ATOM 2886 C CB  . ILE B 1 249 ? 72.720  80.368  77.966  1.00 93.70 ? 249 ILE B CB  1 
ATOM 2887 C CG1 . ILE B 1 249 ? 72.834  80.822  79.436  1.00 91.15 ? 249 ILE B CG1 1 
ATOM 2888 C CG2 . ILE B 1 249 ? 73.946  79.513  77.573  1.00 91.85 ? 249 ILE B CG2 1 
ATOM 2889 C CD1 . ILE B 1 249 ? 74.086  81.645  79.776  1.00 87.28 ? 249 ILE B CD1 1 
ATOM 2890 N N   . VAL B 1 250 ? 71.475  80.538  75.058  1.00 92.13 ? 250 VAL B N   1 
ATOM 2891 C CA  . VAL B 1 250 ? 71.397  79.974  73.706  1.00 90.65 ? 250 VAL B CA  1 
ATOM 2892 C C   . VAL B 1 250 ? 71.423  81.084  72.649  1.00 87.60 ? 250 VAL B C   1 
ATOM 2893 O O   . VAL B 1 250 ? 72.260  81.051  71.742  1.00 80.54 ? 250 VAL B O   1 
ATOM 2894 C CB  . VAL B 1 250 ? 70.170  79.047  73.590  1.00 89.82 ? 250 VAL B CB  1 
ATOM 2895 C CG1 . VAL B 1 250 ? 70.068  78.456  72.190  1.00 79.96 ? 250 VAL B CG1 1 
ATOM 2896 C CG2 . VAL B 1 250 ? 70.294  77.877  74.574  1.00 81.23 ? 250 VAL B CG2 1 
ATOM 2897 N N   . GLY B 1 251 ? 70.569  82.100  72.803  1.00 85.33 ? 251 GLY B N   1 
ATOM 2898 C CA  . GLY B 1 251 ? 70.460  83.213  71.870  1.00 82.16 ? 251 GLY B CA  1 
ATOM 2899 C C   . GLY B 1 251 ? 69.568  82.916  70.658  1.00 80.45 ? 251 GLY B C   1 
ATOM 2900 O O   . GLY B 1 251 ? 68.954  81.861  70.563  1.00 74.15 ? 251 GLY B O   1 
ATOM 2901 N N   . ARG B 1 252 ? 69.499  83.869  69.727  1.00 74.47 ? 252 ARG B N   1 
ATOM 2902 C CA  . ARG B 1 252 ? 68.584  83.807  68.562  1.00 69.86 ? 252 ARG B CA  1 
ATOM 2903 C C   . ARG B 1 252 ? 69.048  82.876  67.444  1.00 68.72 ? 252 ARG B C   1 
ATOM 2904 O O   . ARG B 1 252 ? 68.208  82.382  66.689  1.00 61.06 ? 252 ARG B O   1 
ATOM 2905 C CB  . ARG B 1 252 ? 68.375  85.216  67.974  1.00 63.22 ? 252 ARG B CB  1 
ATOM 2906 C CG  . ARG B 1 252 ? 67.517  86.101  68.881  1.00 55.95 ? 252 ARG B CG  1 
ATOM 2907 C CD  . ARG B 1 252 ? 67.231  87.435  68.203  1.00 51.28 ? 252 ARG B CD  1 
ATOM 2908 N NE  . ARG B 1 252 ? 66.356  88.278  69.052  1.00 45.60 ? 252 ARG B NE  1 
ATOM 2909 C CZ  . ARG B 1 252 ? 65.987  89.536  68.835  1.00 40.35 ? 252 ARG B CZ  1 
ATOM 2910 N NH1 . ARG B 1 252 ? 66.385  90.195  67.773  1.00 37.37 ? 252 ARG B NH1 1 
ATOM 2911 N NH2 . ARG B 1 252 ? 65.224  90.140  69.684  1.00 35.12 ? 252 ARG B NH2 1 
ATOM 2912 N N   . ASP B 1 253 ? 70.347  82.704  67.313  1.00 64.45 ? 253 ASP B N   1 
ATOM 2913 C CA  . ASP B 1 253 ? 70.959  81.861  66.282  1.00 63.03 ? 253 ASP B CA  1 
ATOM 2914 C C   . ASP B 1 253 ? 71.929  80.880  66.962  1.00 66.30 ? 253 ASP B C   1 
ATOM 2915 O O   . ASP B 1 253 ? 73.137  81.090  67.003  1.00 60.08 ? 253 ASP B O   1 
ATOM 2916 C CB  . ASP B 1 253 ? 71.630  82.735  65.214  1.00 54.46 ? 253 ASP B CB  1 
ATOM 2917 C CG  . ASP B 1 253 ? 72.040  81.915  63.980  1.00 47.56 ? 253 ASP B CG  1 
ATOM 2918 O OD1 . ASP B 1 253 ? 71.738  80.696  63.937  1.00 42.00 ? 253 ASP B OD1 1 
ATOM 2919 O OD2 . ASP B 1 253 ? 72.625  82.525  63.059  1.00 41.57 ? 253 ASP B OD2 1 
ATOM 2920 N N   . PRO B 1 254 ? 71.372  79.837  67.568  1.00 70.20 ? 254 PRO B N   1 
ATOM 2921 C CA  . PRO B 1 254 ? 72.148  79.012  68.481  1.00 69.04 ? 254 PRO B CA  1 
ATOM 2922 C C   . PRO B 1 254 ? 73.128  78.048  67.797  1.00 71.84 ? 254 PRO B C   1 
ATOM 2923 O O   . PRO B 1 254 ? 74.088  77.619  68.433  1.00 67.10 ? 254 PRO B O   1 
ATOM 2924 C CB  . PRO B 1 254 ? 71.096  78.255  69.295  1.00 63.16 ? 254 PRO B CB  1 
ATOM 2925 C CG  . PRO B 1 254 ? 69.898  78.159  68.360  1.00 61.95 ? 254 PRO B CG  1 
ATOM 2926 C CD  . PRO B 1 254 ? 69.963  79.470  67.595  1.00 65.08 ? 254 PRO B CD  1 
ATOM 2927 N N   . GLY B 1 255 ? 72.858  77.673  66.545  1.00 77.11 ? 255 GLY B N   1 
ATOM 2928 C CA  . GLY B 1 255 ? 73.515  76.505  65.952  1.00 80.11 ? 255 GLY B CA  1 
ATOM 2929 C C   . GLY B 1 255 ? 73.146  75.176  66.629  1.00 84.61 ? 255 GLY B C   1 
ATOM 2930 O O   . GLY B 1 255 ? 73.801  74.161  66.388  1.00 82.54 ? 255 GLY B O   1 
ATOM 2931 N N   . LEU B 1 256 ? 72.115  75.172  67.480  1.00 88.28 ? 256 LEU B N   1 
ATOM 2932 C CA  . LEU B 1 256 ? 71.616  74.013  68.214  1.00 90.25 ? 256 LEU B CA  1 
ATOM 2933 C C   . LEU B 1 256 ? 70.189  73.664  67.764  1.00 89.82 ? 256 LEU B C   1 
ATOM 2934 O O   . LEU B 1 256 ? 69.376  74.549  67.503  1.00 88.41 ? 256 LEU B O   1 
ATOM 2935 C CB  . LEU B 1 256 ? 71.657  74.288  69.725  1.00 91.00 ? 256 LEU B CB  1 
ATOM 2936 C CG  . LEU B 1 256 ? 73.065  74.466  70.328  1.00 91.56 ? 256 LEU B CG  1 
ATOM 2937 C CD1 . LEU B 1 256 ? 72.966  74.885  71.790  1.00 88.48 ? 256 LEU B CD1 1 
ATOM 2938 C CD2 . LEU B 1 256 ? 73.882  73.176  70.251  1.00 88.57 ? 256 LEU B CD2 1 
ATOM 2939 N N   . ILE B 1 257 ? 69.878  72.376  67.744  1.00 90.63 ? 257 ILE B N   1 
ATOM 2940 C CA  . ILE B 1 257 ? 68.527  71.857  67.521  1.00 90.30 ? 257 ILE B CA  1 
ATOM 2941 C C   . ILE B 1 257 ? 67.789  71.901  68.848  1.00 91.49 ? 257 ILE B C   1 
ATOM 2942 O O   . ILE B 1 257 ? 68.284  71.381  69.843  1.00 91.16 ? 257 ILE B O   1 
ATOM 2943 C CB  . ILE B 1 257 ? 68.574  70.419  66.963  1.00 88.24 ? 257 ILE B CB  1 
ATOM 2944 C CG1 . ILE B 1 257 ? 69.444  70.316  65.697  1.00 80.17 ? 257 ILE B CG1 1 
ATOM 2945 C CG2 . ILE B 1 257 ? 67.147  69.921  66.659  1.00 77.81 ? 257 ILE B CG2 1 
ATOM 2946 C CD1 . ILE B 1 257 ? 69.956  68.893  65.474  1.00 70.06 ? 257 ILE B CD1 1 
ATOM 2947 N N   . GLN B 1 258 ? 66.592  72.493  68.865  1.00 90.57 ? 258 GLN B N   1 
ATOM 2948 C CA  . GLN B 1 258 ? 65.696  72.409  70.011  1.00 89.80 ? 258 GLN B CA  1 
ATOM 2949 C C   . GLN B 1 258 ? 64.906  71.102  69.951  1.00 89.41 ? 258 GLN B C   1 
ATOM 2950 O O   . GLN B 1 258 ? 64.186  70.854  68.980  1.00 88.38 ? 258 GLN B O   1 
ATOM 2951 C CB  . GLN B 1 258 ? 64.803  73.656  70.061  1.00 88.11 ? 258 GLN B CB  1 
ATOM 2952 C CG  . GLN B 1 258 ? 63.928  73.677  71.324  1.00 83.91 ? 258 GLN B CG  1 
ATOM 2953 C CD  . GLN B 1 258 ? 63.026  74.915  71.397  1.00 82.46 ? 258 GLN B CD  1 
ATOM 2954 O OE1 . GLN B 1 258 ? 63.330  75.992  70.921  1.00 76.41 ? 258 GLN B OE1 1 
ATOM 2955 N NE2 . GLN B 1 258 ? 61.876  74.783  72.007  1.00 74.03 ? 258 GLN B NE2 1 
ATOM 2956 N N   . LEU B 1 259 ? 65.027  70.285  70.983  1.00 91.39 ? 259 LEU B N   1 
ATOM 2957 C CA  . LEU B 1 259 ? 64.370  68.987  71.075  1.00 91.11 ? 259 LEU B CA  1 
ATOM 2958 C C   . LEU B 1 259 ? 62.985  69.118  71.717  1.00 89.88 ? 259 LEU B C   1 
ATOM 2959 O O   . LEU B 1 259 ? 62.844  69.683  72.809  1.00 87.34 ? 259 LEU B O   1 
ATOM 2960 C CB  . LEU B 1 259 ? 65.263  68.008  71.856  1.00 91.49 ? 259 LEU B CB  1 
ATOM 2961 C CG  . LEU B 1 259 ? 66.694  67.845  71.315  1.00 91.52 ? 259 LEU B CG  1 
ATOM 2962 C CD1 . LEU B 1 259 ? 67.460  66.846  72.180  1.00 87.05 ? 259 LEU B CD1 1 
ATOM 2963 C CD2 . LEU B 1 259 ? 66.723  67.347  69.874  1.00 86.72 ? 259 LEU B CD2 1 
ATOM 2964 N N   . SER B 1 260 ? 61.975  68.545  71.064  1.00 87.19 ? 260 SER B N   1 
ATOM 2965 C CA  . SER B 1 260 ? 60.605  68.514  71.571  1.00 84.95 ? 260 SER B CA  1 
ATOM 2966 C C   . SER B 1 260 ? 60.340  67.196  72.301  1.00 85.66 ? 260 SER B C   1 
ATOM 2967 O O   . SER B 1 260 ? 59.872  66.233  71.704  1.00 80.36 ? 260 SER B O   1 
ATOM 2968 C CB  . SER B 1 260 ? 59.615  68.722  70.414  1.00 79.27 ? 260 SER B CB  1 
ATOM 2969 O OG  . SER B 1 260 ? 59.758  70.031  69.902  1.00 67.29 ? 260 SER B OG  1 
ATOM 2970 N N   . LEU B 1 261 ? 60.619  67.160  73.605  1.00 87.87 ? 261 LEU B N   1 
ATOM 2971 C CA  . LEU B 1 261 ? 60.476  65.941  74.420  1.00 88.01 ? 261 LEU B CA  1 
ATOM 2972 C C   . LEU B 1 261 ? 59.068  65.750  75.025  1.00 86.29 ? 261 LEU B C   1 
ATOM 2973 O O   . LEU B 1 261 ? 58.901  64.929  75.925  1.00 78.76 ? 261 LEU B O   1 
ATOM 2974 C CB  . LEU B 1 261 ? 61.572  65.914  75.499  1.00 87.50 ? 261 LEU B CB  1 
ATOM 2975 C CG  . LEU B 1 261 ? 63.012  65.964  74.965  1.00 88.76 ? 261 LEU B CG  1 
ATOM 2976 C CD1 . LEU B 1 261 ? 63.986  65.892  76.134  1.00 83.23 ? 261 LEU B CD1 1 
ATOM 2977 C CD2 . LEU B 1 261 ? 63.328  64.814  74.011  1.00 83.88 ? 261 LEU B CD2 1 
ATOM 2978 N N   . ALA B 1 262 ? 58.069  66.488  74.543  1.00 82.93 ? 262 ALA B N   1 
ATOM 2979 C CA  . ALA B 1 262 ? 56.708  66.493  75.093  1.00 81.11 ? 262 ALA B CA  1 
ATOM 2980 C C   . ALA B 1 262 ? 56.657  66.786  76.612  1.00 82.33 ? 262 ALA B C   1 
ATOM 2981 O O   . ALA B 1 262 ? 55.817  66.247  77.338  1.00 76.49 ? 262 ALA B O   1 
ATOM 2982 C CB  . ALA B 1 262 ? 55.966  65.219  74.673  1.00 75.76 ? 262 ALA B CB  1 
ATOM 2983 N N   . ALA B 1 263 ? 57.558  67.623  77.087  1.00 83.69 ? 263 ALA B N   1 
ATOM 2984 C CA  . ALA B 1 263 ? 57.632  68.054  78.472  1.00 83.16 ? 263 ALA B CA  1 
ATOM 2985 C C   . ALA B 1 263 ? 57.866  69.568  78.545  1.00 84.23 ? 263 ALA B C   1 
ATOM 2986 O O   . ALA B 1 263 ? 58.702  70.104  77.819  1.00 78.96 ? 263 ALA B O   1 
ATOM 2987 C CB  . ALA B 1 263 ? 58.745  67.281  79.176  1.00 78.01 ? 263 ALA B CB  1 
ATOM 2988 N N   . ASP B 1 264 ? 57.149  70.238  79.450  1.00 84.09 ? 264 ASP B N   1 
ATOM 2989 C CA  . ASP B 1 264 ? 57.352  71.647  79.743  1.00 84.07 ? 264 ASP B CA  1 
ATOM 2990 C C   . ASP B 1 264 ? 58.312  71.811  80.924  1.00 86.45 ? 264 ASP B C   1 
ATOM 2991 O O   . ASP B 1 264 ? 58.137  71.199  81.981  1.00 83.16 ? 264 ASP B O   1 
ATOM 2992 C CB  . ASP B 1 264 ? 56.007  72.343  80.020  1.00 77.34 ? 264 ASP B CB  1 
ATOM 2993 C CG  . ASP B 1 264 ? 55.185  72.607  78.753  1.00 67.30 ? 264 ASP B CG  1 
ATOM 2994 O OD1 . ASP B 1 264 ? 55.793  73.008  77.733  1.00 58.84 ? 264 ASP B OD1 1 
ATOM 2995 O OD2 . ASP B 1 264 ? 53.952  72.465  78.829  1.00 58.53 ? 264 ASP B OD2 1 
ATOM 2996 N N   . ILE B 1 265 ? 59.299  72.667  80.747  1.00 88.53 ? 265 ILE B N   1 
ATOM 2997 C CA  . ILE B 1 265 ? 60.202  73.109  81.812  1.00 90.19 ? 265 ILE B CA  1 
ATOM 2998 C C   . ILE B 1 265 ? 59.675  74.450  82.328  1.00 89.92 ? 265 ILE B C   1 
ATOM 2999 O O   . ILE B 1 265 ? 59.350  75.321  81.514  1.00 87.77 ? 265 ILE B O   1 
ATOM 3000 C CB  . ILE B 1 265 ? 61.659  73.203  81.298  1.00 90.18 ? 265 ILE B CB  1 
ATOM 3001 C CG1 . ILE B 1 265 ? 62.102  71.874  80.640  1.00 87.12 ? 265 ILE B CG1 1 
ATOM 3002 C CG2 . ILE B 1 265 ? 62.592  73.570  82.464  1.00 85.62 ? 265 ILE B CG2 1 
ATOM 3003 C CD1 . ILE B 1 265 ? 63.444  71.960  79.920  1.00 81.30 ? 265 ILE B CD1 1 
ATOM 3004 N N   . PRO B 1 266 ? 59.590  74.661  83.644  1.00 89.31 ? 266 PRO B N   1 
ATOM 3005 C CA  . PRO B 1 266 ? 59.102  75.916  84.194  1.00 88.57 ? 266 PRO B CA  1 
ATOM 3006 C C   . PRO B 1 266 ? 59.889  77.129  83.682  1.00 89.41 ? 266 PRO B C   1 
ATOM 3007 O O   . PRO B 1 266 ? 61.117  77.133  83.660  1.00 87.94 ? 266 PRO B O   1 
ATOM 3008 C CB  . PRO B 1 266 ? 59.198  75.777  85.717  1.00 85.89 ? 266 PRO B CB  1 
ATOM 3009 C CG  . PRO B 1 266 ? 59.117  74.262  85.936  1.00 83.78 ? 266 PRO B CG  1 
ATOM 3010 C CD  . PRO B 1 266 ? 59.838  73.707  84.713  1.00 86.97 ? 266 PRO B CD  1 
ATOM 3011 N N   . SER B 1 267 ? 59.161  78.181  83.313  1.00 90.06 ? 267 SER B N   1 
ATOM 3012 C CA  . SER B 1 267 ? 59.752  79.493  83.050  1.00 90.15 ? 267 SER B CA  1 
ATOM 3013 C C   . SER B 1 267 ? 59.925  80.279  84.353  1.00 90.47 ? 267 SER B C   1 
ATOM 3014 O O   . SER B 1 267 ? 59.251  80.024  85.353  1.00 89.17 ? 267 SER B O   1 
ATOM 3015 C CB  . SER B 1 267 ? 58.912  80.263  82.033  1.00 88.05 ? 267 SER B CB  1 
ATOM 3016 O OG  . SER B 1 267 ? 57.629  80.567  82.535  1.00 81.10 ? 267 SER B OG  1 
ATOM 3017 N N   . PHE B 1 268 ? 60.801  81.270  84.328  1.00 91.05 ? 268 PHE B N   1 
ATOM 3018 C CA  . PHE B 1 268 ? 60.995  82.183  85.448  1.00 91.27 ? 268 PHE B CA  1 
ATOM 3019 C C   . PHE B 1 268 ? 61.214  83.609  84.953  1.00 91.61 ? 268 PHE B C   1 
ATOM 3020 O O   . PHE B 1 268 ? 61.630  83.844  83.824  1.00 90.59 ? 268 PHE B O   1 
ATOM 3021 C CB  . PHE B 1 268 ? 62.141  81.690  86.345  1.00 89.98 ? 268 PHE B CB  1 
ATOM 3022 C CG  . PHE B 1 268 ? 63.480  81.554  85.649  1.00 89.81 ? 268 PHE B CG  1 
ATOM 3023 C CD1 . PHE B 1 268 ? 63.829  80.335  85.025  1.00 85.21 ? 268 PHE B CD1 1 
ATOM 3024 C CD2 . PHE B 1 268 ? 64.392  82.626  85.641  1.00 85.78 ? 268 PHE B CD2 1 
ATOM 3025 C CE1 . PHE B 1 268 ? 65.079  80.201  84.402  1.00 83.76 ? 268 PHE B CE1 1 
ATOM 3026 C CE2 . PHE B 1 268 ? 65.638  82.486  85.019  1.00 84.03 ? 268 PHE B CE2 1 
ATOM 3027 C CZ  . PHE B 1 268 ? 65.988  81.276  84.399  1.00 85.75 ? 268 PHE B CZ  1 
ATOM 3028 N N   . ASP B 1 269 ? 60.934  84.581  85.817  1.00 92.03 ? 269 ASP B N   1 
ATOM 3029 C CA  . ASP B 1 269 ? 61.091  85.990  85.495  1.00 92.58 ? 269 ASP B CA  1 
ATOM 3030 C C   . ASP B 1 269 ? 62.422  86.540  86.010  1.00 93.01 ? 269 ASP B C   1 
ATOM 3031 O O   . ASP B 1 269 ? 62.858  86.218  87.120  1.00 92.09 ? 269 ASP B O   1 
ATOM 3032 C CB  . ASP B 1 269 ? 59.900  86.776  86.048  1.00 91.55 ? 269 ASP B CB  1 
ATOM 3033 C CG  . ASP B 1 269 ? 58.576  86.523  85.322  1.00 90.56 ? 269 ASP B CG  1 
ATOM 3034 O OD1 . ASP B 1 269 ? 58.570  86.315  84.086  1.00 86.63 ? 269 ASP B OD1 1 
ATOM 3035 O OD2 . ASP B 1 269 ? 57.513  86.750  85.929  1.00 86.03 ? 269 ASP B OD2 1 
ATOM 3036 N N   . THR B 1 270 ? 63.023  87.440  85.234  1.00 94.34 ? 270 THR B N   1 
ATOM 3037 C CA  . THR B 1 270 ? 64.162  88.247  85.659  1.00 94.62 ? 270 THR B CA  1 
ATOM 3038 C C   . THR B 1 270 ? 63.719  89.630  86.131  1.00 94.74 ? 270 THR B C   1 
ATOM 3039 O O   . THR B 1 270 ? 62.726  90.189  85.646  1.00 93.83 ? 270 THR B O   1 
ATOM 3040 C CB  . THR B 1 270 ? 65.230  88.377  84.562  1.00 93.90 ? 270 THR B CB  1 
ATOM 3041 O OG1 . THR B 1 270 ? 64.677  88.953  83.406  1.00 86.95 ? 270 THR B OG1 1 
ATOM 3042 C CG2 . THR B 1 270 ? 65.814  87.026  84.174  1.00 85.69 ? 270 THR B CG2 1 
ATOM 3043 N N   . TYR B 1 271 ? 64.469  90.198  87.068  1.00 95.09 ? 271 TYR B N   1 
ATOM 3044 C CA  . TYR B 1 271 ? 64.173  91.493  87.670  1.00 95.20 ? 271 TYR B CA  1 
ATOM 3045 C C   . TYR B 1 271 ? 65.424  92.361  87.736  1.00 95.43 ? 271 TYR B C   1 
ATOM 3046 O O   . TYR B 1 271 ? 66.488  91.912  88.151  1.00 94.56 ? 271 TYR B O   1 
ATOM 3047 C CB  . TYR B 1 271 ? 63.587  91.297  89.077  1.00 94.82 ? 271 TYR B CB  1 
ATOM 3048 C CG  . TYR B 1 271 ? 62.249  90.590  89.092  1.00 94.37 ? 271 TYR B CG  1 
ATOM 3049 C CD1 . TYR B 1 271 ? 61.046  91.321  89.142  1.00 91.42 ? 271 TYR B CD1 1 
ATOM 3050 C CD2 . TYR B 1 271 ? 62.190  89.185  89.015  1.00 91.93 ? 271 TYR B CD2 1 
ATOM 3051 C CE1 . TYR B 1 271 ? 59.812  90.671  89.115  1.00 90.96 ? 271 TYR B CE1 1 
ATOM 3052 C CE2 . TYR B 1 271 ? 60.951  88.512  88.977  1.00 90.77 ? 271 TYR B CE2 1 
ATOM 3053 C CZ  . TYR B 1 271 ? 59.767  89.266  89.027  1.00 92.11 ? 271 TYR B CZ  1 
ATOM 3054 O OH  . TYR B 1 271 ? 58.563  88.621  88.974  1.00 90.28 ? 271 TYR B OH  1 
ATOM 3055 N N   . PHE B 1 272 ? 65.273  93.645  87.381  1.00 95.34 ? 272 PHE B N   1 
ATOM 3056 C CA  . PHE B 1 272 ? 66.246  94.683  87.708  1.00 95.58 ? 272 PHE B CA  1 
ATOM 3057 C C   . PHE B 1 272 ? 65.882  95.295  89.061  1.00 95.37 ? 272 PHE B C   1 
ATOM 3058 O O   . PHE B 1 272 ? 64.721  95.657  89.270  1.00 94.45 ? 272 PHE B O   1 
ATOM 3059 C CB  . PHE B 1 272 ? 66.280  95.727  86.597  1.00 95.51 ? 272 PHE B CB  1 
ATOM 3060 C CG  . PHE B 1 272 ? 67.336  96.788  86.802  1.00 95.86 ? 272 PHE B CG  1 
ATOM 3061 C CD1 . PHE B 1 272 ? 67.014  98.030  87.386  1.00 93.30 ? 272 PHE B CD1 1 
ATOM 3062 C CD2 . PHE B 1 272 ? 68.667  96.533  86.427  1.00 93.55 ? 272 PHE B CD2 1 
ATOM 3063 C CE1 . PHE B 1 272 ? 68.002  99.009  87.576  1.00 93.14 ? 272 PHE B CE1 1 
ATOM 3064 C CE2 . PHE B 1 272 ? 69.661  97.505  86.617  1.00 93.03 ? 272 PHE B CE2 1 
ATOM 3065 C CZ  . PHE B 1 272 ? 69.331  98.746  87.189  1.00 94.86 ? 272 PHE B CZ  1 
ATOM 3066 N N   . CYS B 1 273 ? 66.840  95.420  89.944  1.00 95.30 ? 273 CYS B N   1 
ATOM 3067 C CA  . CYS B 1 273 ? 66.629  96.020  91.250  1.00 94.94 ? 273 CYS B CA  1 
ATOM 3068 C C   . CYS B 1 273 ? 67.792  96.914  91.683  1.00 95.31 ? 273 CYS B C   1 
ATOM 3069 O O   . CYS B 1 273 ? 68.933  96.749  91.248  1.00 94.55 ? 273 CYS B O   1 
ATOM 3070 C CB  . CYS B 1 273 ? 66.294  94.930  92.279  1.00 92.92 ? 273 CYS B CB  1 
ATOM 3071 S SG  . CYS B 1 273 ? 67.693  93.802  92.558  1.00 86.64 ? 273 CYS B SG  1 
ATOM 3072 N N   . TYR B 1 274 ? 67.473  97.885  92.535  1.00 94.27 ? 274 TYR B N   1 
ATOM 3073 C CA  . TYR B 1 274 ? 68.433  98.852  93.067  1.00 94.15 ? 274 TYR B CA  1 
ATOM 3074 C C   . TYR B 1 274 ? 67.911  99.448  94.385  1.00 93.79 ? 274 TYR B C   1 
ATOM 3075 O O   . TYR B 1 274 ? 66.693  99.527  94.573  1.00 92.59 ? 274 TYR B O   1 
ATOM 3076 C CB  . TYR B 1 274 ? 68.709  99.943  92.025  1.00 93.59 ? 274 TYR B CB  1 
ATOM 3077 C CG  . TYR B 1 274 ? 67.488  100.681 91.514  1.00 93.62 ? 274 TYR B CG  1 
ATOM 3078 C CD1 . TYR B 1 274 ? 66.720  100.144 90.457  1.00 91.38 ? 274 TYR B CD1 1 
ATOM 3079 C CD2 . TYR B 1 274 ? 67.099  101.906 92.090  1.00 91.47 ? 274 TYR B CD2 1 
ATOM 3080 C CE1 . TYR B 1 274 ? 65.589  100.815 89.980  1.00 90.48 ? 274 TYR B CE1 1 
ATOM 3081 C CE2 . TYR B 1 274 ? 65.963  102.590 91.621  1.00 90.31 ? 274 TYR B CE2 1 
ATOM 3082 C CZ  . TYR B 1 274 ? 65.212  102.041 90.566  1.00 91.15 ? 274 TYR B CZ  1 
ATOM 3083 O OH  . TYR B 1 274 ? 64.102  102.707 90.103  1.00 89.60 ? 274 TYR B OH  1 
ATOM 3084 N N   . PRO B 1 275 ? 68.791  99.900  95.296  1.00 92.40 ? 275 PRO B N   1 
ATOM 3085 C CA  . PRO B 1 275 ? 68.378  100.524 96.544  1.00 91.20 ? 275 PRO B CA  1 
ATOM 3086 C C   . PRO B 1 275 ? 67.778  101.919 96.299  1.00 90.84 ? 275 PRO B C   1 
ATOM 3087 O O   . PRO B 1 275 ? 68.163  102.623 95.362  1.00 89.14 ? 275 PRO B O   1 
ATOM 3088 C CB  . PRO B 1 275 ? 69.647  100.578 97.402  1.00 89.36 ? 275 PRO B CB  1 
ATOM 3089 C CG  . PRO B 1 275 ? 70.766  100.673 96.372  1.00 86.89 ? 275 PRO B CG  1 
ATOM 3090 C CD  . PRO B 1 275 ? 70.243  99.831  95.209  1.00 90.42 ? 275 PRO B CD  1 
ATOM 3091 N N   . ASP B 1 276 ? 66.859  102.345 97.168  1.00 89.63 ? 276 ASP B N   1 
ATOM 3092 C CA  . ASP B 1 276 ? 66.189  103.648 97.051  1.00 88.21 ? 276 ASP B CA  1 
ATOM 3093 C C   . ASP B 1 276 ? 67.179  104.829 97.040  1.00 87.50 ? 276 ASP B C   1 
ATOM 3094 O O   . ASP B 1 276 ? 66.953  105.844 96.375  1.00 83.92 ? 276 ASP B O   1 
ATOM 3095 C CB  . ASP B 1 276 ? 65.167  103.801 98.193  1.00 85.99 ? 276 ASP B CB  1 
ATOM 3096 C CG  . ASP B 1 276 ? 64.259  105.023 97.991  1.00 79.59 ? 276 ASP B CG  1 
ATOM 3097 O OD1 . ASP B 1 276 ? 63.444  105.010 97.050  1.00 71.66 ? 276 ASP B OD1 1 
ATOM 3098 O OD2 . ASP B 1 276 ? 64.362  106.029 98.727  1.00 70.22 ? 276 ASP B OD2 1 
ATOM 3099 N N   . GLU B 1 277 ? 68.325  104.666 97.691  1.00 87.33 ? 277 GLU B N   1 
ATOM 3100 C CA  . GLU B 1 277 ? 69.431  105.638 97.712  1.00 85.69 ? 277 GLU B CA  1 
ATOM 3101 C C   . GLU B 1 277 ? 69.918  106.006 96.299  1.00 86.29 ? 277 GLU B C   1 
ATOM 3102 O O   . GLU B 1 277 ? 70.323  107.140 96.049  1.00 83.79 ? 277 GLU B O   1 
ATOM 3103 C CB  . GLU B 1 277 ? 70.625  105.057 98.498  1.00 82.31 ? 277 GLU B CB  1 
ATOM 3104 C CG  . GLU B 1 277 ? 70.297  104.593 99.928  1.00 72.12 ? 277 GLU B CG  1 
ATOM 3105 C CD  . GLU B 1 277 ? 71.506  103.984 100.655 1.00 66.90 ? 277 GLU B CD  1 
ATOM 3106 O OE1 . GLU B 1 277 ? 71.300  103.061 101.464 1.00 58.62 ? 277 GLU B OE1 1 
ATOM 3107 O OE2 . GLU B 1 277 ? 72.659  104.437 100.411 1.00 60.26 ? 277 GLU B OE2 1 
ATOM 3108 N N   . MET B 1 278 ? 69.846  105.069 95.367  1.00 86.35 ? 278 MET B N   1 
ATOM 3109 C CA  . MET B 1 278 ? 70.349  105.230 94.002  1.00 86.46 ? 278 MET B CA  1 
ATOM 3110 C C   . MET B 1 278 ? 69.301  105.777 93.020  1.00 87.32 ? 278 MET B C   1 
ATOM 3111 O O   . MET B 1 278 ? 69.648  106.132 91.899  1.00 85.42 ? 278 MET B O   1 
ATOM 3112 C CB  . MET B 1 278 ? 70.918  103.888 93.508  1.00 84.91 ? 278 MET B CB  1 
ATOM 3113 C CG  . MET B 1 278 ? 72.209  103.481 94.240  1.00 80.85 ? 278 MET B CG  1 
ATOM 3114 S SD  . MET B 1 278 ? 73.650  104.581 93.976  1.00 78.72 ? 278 MET B SD  1 
ATOM 3115 C CE  . MET B 1 278 ? 73.971  104.302 92.221  1.00 69.83 ? 278 MET B CE  1 
ATOM 3116 N N   . LYS B 1 279 ? 68.017  105.892 93.414  1.00 87.31 ? 279 LYS B N   1 
ATOM 3117 C CA  . LYS B 1 279 ? 66.902  106.211 92.506  1.00 86.88 ? 279 LYS B CA  1 
ATOM 3118 C C   . LYS B 1 279 ? 67.043  107.524 91.727  1.00 87.06 ? 279 LYS B C   1 
ATOM 3119 O O   . LYS B 1 279 ? 66.430  107.676 90.669  1.00 84.39 ? 279 LYS B O   1 
ATOM 3120 C CB  . LYS B 1 279 ? 65.582  106.203 93.292  1.00 84.98 ? 279 LYS B CB  1 
ATOM 3121 C CG  . LYS B 1 279 ? 65.357  107.457 94.157  1.00 81.14 ? 279 LYS B CG  1 
ATOM 3122 C CD  . LYS B 1 279 ? 64.115  107.244 95.032  1.00 79.28 ? 279 LYS B CD  1 
ATOM 3123 C CE  . LYS B 1 279 ? 63.985  108.331 96.092  1.00 70.33 ? 279 LYS B CE  1 
ATOM 3124 N NZ  . LYS B 1 279 ? 63.054  107.880 97.151  1.00 64.19 ? 279 LYS B NZ  1 
ATOM 3125 N N   . ASN B 1 280 ? 67.810  108.461 92.260  1.00 87.52 ? 280 ASN B N   1 
ATOM 3126 C CA  . ASN B 1 280 ? 68.013  109.772 91.659  1.00 87.03 ? 280 ASN B CA  1 
ATOM 3127 C C   . ASN B 1 280 ? 69.352  109.919 90.918  1.00 87.12 ? 280 ASN B C   1 
ATOM 3128 O O   . ASN B 1 280 ? 69.553  110.922 90.241  1.00 83.86 ? 280 ASN B O   1 
ATOM 3129 C CB  . ASN B 1 280 ? 67.821  110.851 92.742  1.00 85.34 ? 280 ASN B CB  1 
ATOM 3130 C CG  . ASN B 1 280 ? 66.373  110.978 93.185  1.00 83.34 ? 280 ASN B CG  1 
ATOM 3131 O OD1 . ASN B 1 280 ? 65.437  110.823 92.427  1.00 76.17 ? 280 ASN B OD1 1 
ATOM 3132 N ND2 . ASN B 1 280 ? 66.146  111.303 94.443  1.00 74.42 ? 280 ASN B ND2 1 
ATOM 3133 N N   . ALA B 1 281 ? 70.238  108.946 91.006  1.00 88.73 ? 281 ALA B N   1 
ATOM 3134 C CA  . ALA B 1 281 ? 71.522  108.979 90.321  1.00 88.94 ? 281 ALA B CA  1 
ATOM 3135 C C   . ALA B 1 281 ? 71.328  108.879 88.793  1.00 89.65 ? 281 ALA B C   1 
ATOM 3136 O O   . ALA B 1 281 ? 70.792  107.892 88.303  1.00 88.62 ? 281 ALA B O   1 
ATOM 3137 C CB  . ALA B 1 281 ? 72.411  107.856 90.871  1.00 87.00 ? 281 ALA B CB  1 
ATOM 3138 N N   . ALA B 1 282 ? 71.804  109.875 88.049  1.00 88.16 ? 282 ALA B N   1 
ATOM 3139 C CA  . ALA B 1 282 ? 71.680  109.924 86.590  1.00 87.80 ? 282 ALA B CA  1 
ATOM 3140 C C   . ALA B 1 282 ? 72.263  108.674 85.923  1.00 88.91 ? 282 ALA B C   1 
ATOM 3141 O O   . ALA B 1 282 ? 71.598  108.042 85.105  1.00 88.10 ? 282 ALA B O   1 
ATOM 3142 C CB  . ALA B 1 282 ? 72.353  111.205 86.085  1.00 85.37 ? 282 ALA B CB  1 
ATOM 3143 N N   . LYS B 1 283 ? 73.445  108.238 86.342  1.00 90.78 ? 283 LYS B N   1 
ATOM 3144 C CA  . LYS B 1 283 ? 74.107  107.011 85.873  1.00 91.58 ? 283 LYS B CA  1 
ATOM 3145 C C   . LYS B 1 283 ? 73.235  105.756 86.027  1.00 92.25 ? 283 LYS B C   1 
ATOM 3146 O O   . LYS B 1 283 ? 73.228  104.910 85.136  1.00 91.46 ? 283 LYS B O   1 
ATOM 3147 C CB  . LYS B 1 283 ? 75.476  106.849 86.568  1.00 90.01 ? 283 LYS B CB  1 
ATOM 3148 C CG  . LYS B 1 283 ? 75.409  106.643 88.097  1.00 86.75 ? 283 LYS B CG  1 
ATOM 3149 C CD  . LYS B 1 283 ? 76.799  106.420 88.708  1.00 85.45 ? 283 LYS B CD  1 
ATOM 3150 C CE  . LYS B 1 283 ? 76.656  106.078 90.193  1.00 77.72 ? 283 LYS B CE  1 
ATOM 3151 N NZ  . LYS B 1 283 ? 77.913  105.540 90.779  1.00 73.22 ? 283 LYS B NZ  1 
ATOM 3152 N N   . LEU B 1 284 ? 72.481  105.642 87.116  1.00 92.35 ? 284 LEU B N   1 
ATOM 3153 C CA  . LEU B 1 284 ? 71.589  104.503 87.336  1.00 92.70 ? 284 LEU B CA  1 
ATOM 3154 C C   . LEU B 1 284 ? 70.323  104.604 86.486  1.00 92.57 ? 284 LEU B C   1 
ATOM 3155 O O   . LEU B 1 284 ? 69.881  103.594 85.953  1.00 91.48 ? 284 LEU B O   1 
ATOM 3156 C CB  . LEU B 1 284 ? 71.227  104.397 88.827  1.00 92.38 ? 284 LEU B CB  1 
ATOM 3157 C CG  . LEU B 1 284 ? 70.276  103.214 89.122  1.00 90.97 ? 284 LEU B CG  1 
ATOM 3158 C CD1 . LEU B 1 284 ? 70.961  101.858 88.976  1.00 84.29 ? 284 LEU B CD1 1 
ATOM 3159 C CD2 . LEU B 1 284 ? 69.726  103.319 90.538  1.00 83.49 ? 284 LEU B CD2 1 
ATOM 3160 N N   . LYS B 1 285 ? 69.740  105.802 86.347  1.00 90.52 ? 285 LYS B N   1 
ATOM 3161 C CA  . LYS B 1 285 ? 68.563  106.019 85.491  1.00 89.15 ? 285 LYS B CA  1 
ATOM 3162 C C   . LYS B 1 285 ? 68.869  105.640 84.041  1.00 89.31 ? 285 LYS B C   1 
ATOM 3163 O O   . LYS B 1 285 ? 68.119  104.841 83.475  1.00 88.21 ? 285 LYS B O   1 
ATOM 3164 C CB  . LYS B 1 285 ? 68.091  107.478 85.579  1.00 87.35 ? 285 LYS B CB  1 
ATOM 3165 C CG  . LYS B 1 285 ? 67.442  107.815 86.925  1.00 81.41 ? 285 LYS B CG  1 
ATOM 3166 C CD  . LYS B 1 285 ? 67.104  109.314 86.946  1.00 78.31 ? 285 LYS B CD  1 
ATOM 3167 C CE  . LYS B 1 285 ? 66.468  109.714 88.271  1.00 69.60 ? 285 LYS B CE  1 
ATOM 3168 N NZ  . LYS B 1 285 ? 66.417  111.193 88.394  1.00 63.62 ? 285 LYS B NZ  1 
ATOM 3169 N N   . ALA B 1 286 ? 69.974  106.123 83.506  1.00 88.01 ? 286 ALA B N   1 
ATOM 3170 C CA  . ALA B 1 286 ? 70.458  105.789 82.169  1.00 87.52 ? 286 ALA B CA  1 
ATOM 3171 C C   . ALA B 1 286 ? 70.561  104.267 81.966  1.00 87.71 ? 286 ALA B C   1 
ATOM 3172 O O   . ALA B 1 286 ? 69.943  103.707 81.055  1.00 87.05 ? 286 ALA B O   1 
ATOM 3173 C CB  . ALA B 1 286 ? 71.820  106.476 81.968  1.00 86.75 ? 286 ALA B CB  1 
ATOM 3174 N N   . PHE B 1 287 ? 71.252  103.583 82.880  1.00 92.20 ? 287 PHE B N   1 
ATOM 3175 C CA  . PHE B 1 287 ? 71.415  102.127 82.785  1.00 93.12 ? 287 PHE B CA  1 
ATOM 3176 C C   . PHE B 1 287 ? 70.097  101.372 82.970  1.00 92.75 ? 287 PHE B C   1 
ATOM 3177 O O   . PHE B 1 287 ? 69.812  100.450 82.207  1.00 92.11 ? 287 PHE B O   1 
ATOM 3178 C CB  . PHE B 1 287 ? 72.459  101.657 83.793  1.00 94.09 ? 287 PHE B CB  1 
ATOM 3179 C CG  . PHE B 1 287 ? 72.833  100.202 83.607  1.00 94.86 ? 287 PHE B CG  1 
ATOM 3180 C CD1 . PHE B 1 287 ? 72.330  99.219  84.474  1.00 92.85 ? 287 PHE B CD1 1 
ATOM 3181 C CD2 . PHE B 1 287 ? 73.657  99.815  82.535  1.00 92.98 ? 287 PHE B CD2 1 
ATOM 3182 C CE1 . PHE B 1 287 ? 72.649  97.870  84.273  1.00 93.20 ? 287 PHE B CE1 1 
ATOM 3183 C CE2 . PHE B 1 287 ? 73.980  98.469  82.329  1.00 93.28 ? 287 PHE B CE2 1 
ATOM 3184 C CZ  . PHE B 1 287 ? 73.476  97.494  83.196  1.00 95.22 ? 287 PHE B CZ  1 
ATOM 3185 N N   . ARG B 1 288 ? 69.269  101.763 83.945  1.00 92.12 ? 288 ARG B N   1 
ATOM 3186 C CA  . ARG B 1 288 ? 67.951  101.151 84.191  1.00 91.05 ? 288 ARG B CA  1 
ATOM 3187 C C   . ARG B 1 288 ? 67.066  101.231 82.956  1.00 89.95 ? 288 ARG B C   1 
ATOM 3188 O O   . ARG B 1 288 ? 66.481  100.232 82.563  1.00 89.15 ? 288 ARG B O   1 
ATOM 3189 C CB  . ARG B 1 288 ? 67.281  101.862 85.372  1.00 90.43 ? 288 ARG B CB  1 
ATOM 3190 C CG  . ARG B 1 288 ? 65.864  101.337 85.671  1.00 88.86 ? 288 ARG B CG  1 
ATOM 3191 C CD  . ARG B 1 288 ? 65.088  102.326 86.537  1.00 86.60 ? 288 ARG B CD  1 
ATOM 3192 N NE  . ARG B 1 288 ? 64.741  103.536 85.786  1.00 81.95 ? 288 ARG B NE  1 
ATOM 3193 C CZ  . ARG B 1 288 ? 64.523  104.757 86.256  1.00 79.86 ? 288 ARG B CZ  1 
ATOM 3194 N NH1 . ARG B 1 288 ? 64.507  105.020 87.535  1.00 71.34 ? 288 ARG B NH1 1 
ATOM 3195 N NH2 . ARG B 1 288 ? 64.329  105.733 85.426  1.00 74.53 ? 288 ARG B NH2 1 
ATOM 3196 N N   . ASP B 1 289 ? 66.934  102.430 82.396  1.00 87.26 ? 289 ASP B N   1 
ATOM 3197 C CA  . ASP B 1 289 ? 66.004  102.672 81.298  1.00 84.26 ? 289 ASP B CA  1 
ATOM 3198 C C   . ASP B 1 289 ? 66.482  101.968 80.025  1.00 83.38 ? 289 ASP B C   1 
ATOM 3199 O O   . ASP B 1 289 ? 65.679  101.338 79.328  1.00 81.98 ? 289 ASP B O   1 
ATOM 3200 C CB  . ASP B 1 289 ? 65.791  104.194 81.143  1.00 82.54 ? 289 ASP B CB  1 
ATOM 3201 C CG  . ASP B 1 289 ? 65.046  104.827 82.347  1.00 79.99 ? 289 ASP B CG  1 
ATOM 3202 O OD1 . ASP B 1 289 ? 64.437  104.090 83.156  1.00 77.45 ? 289 ASP B OD1 1 
ATOM 3203 O OD2 . ASP B 1 289 ? 65.059  106.059 82.507  1.00 76.48 ? 289 ASP B OD2 1 
ATOM 3204 N N   . PHE B 1 290 ? 67.794  101.943 79.797  1.00 87.31 ? 290 PHE B N   1 
ATOM 3205 C CA  . PHE B 1 290 ? 68.408  101.135 78.747  1.00 86.77 ? 290 PHE B CA  1 
ATOM 3206 C C   . PHE B 1 290 ? 68.117  99.634  78.917  1.00 86.47 ? 290 PHE B C   1 
ATOM 3207 O O   . PHE B 1 290 ? 67.619  99.000  77.992  1.00 86.02 ? 290 PHE B O   1 
ATOM 3208 C CB  . PHE B 1 290 ? 69.921  101.402 78.746  1.00 86.66 ? 290 PHE B CB  1 
ATOM 3209 C CG  . PHE B 1 290 ? 70.683  100.504 77.802  1.00 86.52 ? 290 PHE B CG  1 
ATOM 3210 C CD1 . PHE B 1 290 ? 71.249  99.298  78.261  1.00 83.78 ? 290 PHE B CD1 1 
ATOM 3211 C CD2 . PHE B 1 290 ? 70.824  100.860 76.447  1.00 83.70 ? 290 PHE B CD2 1 
ATOM 3212 C CE1 . PHE B 1 290 ? 71.945  98.459  77.375  1.00 82.92 ? 290 PHE B CE1 1 
ATOM 3213 C CE2 . PHE B 1 290 ? 71.516  100.029 75.562  1.00 82.44 ? 290 PHE B CE2 1 
ATOM 3214 C CZ  . PHE B 1 290 ? 72.076  98.827  76.031  1.00 84.87 ? 290 PHE B CZ  1 
ATOM 3215 N N   . ILE B 1 291 ? 68.378  99.065  80.089  1.00 90.12 ? 291 ILE B N   1 
ATOM 3216 C CA  . ILE B 1 291 ? 68.170  97.633  80.351  1.00 90.80 ? 291 ILE B CA  1 
ATOM 3217 C C   . ILE B 1 291 ? 66.693  97.249  80.243  1.00 89.43 ? 291 ILE B C   1 
ATOM 3218 O O   . ILE B 1 291 ? 66.370  96.234  79.636  1.00 88.06 ? 291 ILE B O   1 
ATOM 3219 C CB  . ILE B 1 291 ? 68.778  97.231  81.710  1.00 91.72 ? 291 ILE B CB  1 
ATOM 3220 C CG1 . ILE B 1 291 ? 70.324  97.177  81.631  1.00 87.71 ? 291 ILE B CG1 1 
ATOM 3221 C CG2 . ILE B 1 291 ? 68.236  95.893  82.249  1.00 88.82 ? 291 ILE B CG2 1 
ATOM 3222 C CD1 . ILE B 1 291 ? 70.928  96.048  80.780  1.00 83.77 ? 291 ILE B CD1 1 
ATOM 3223 N N   . VAL B 1 292 ? 65.781  98.076  80.771  1.00 87.21 ? 292 VAL B N   1 
ATOM 3224 C CA  . VAL B 1 292 ? 64.340  97.853  80.648  1.00 85.12 ? 292 VAL B CA  1 
ATOM 3225 C C   . VAL B 1 292 ? 63.904  97.867  79.175  1.00 82.87 ? 292 VAL B C   1 
ATOM 3226 O O   . VAL B 1 292 ? 63.136  96.998  78.762  1.00 80.69 ? 292 VAL B O   1 
ATOM 3227 C CB  . VAL B 1 292 ? 63.546  98.883  81.482  1.00 84.83 ? 292 VAL B CB  1 
ATOM 3228 C CG1 . VAL B 1 292 ? 62.041  98.854  81.192  1.00 82.20 ? 292 VAL B CG1 1 
ATOM 3229 C CG2 . VAL B 1 292 ? 63.717  98.609  82.985  1.00 82.74 ? 292 VAL B CG2 1 
ATOM 3230 N N   . ALA B 1 293 ? 64.414  98.802  78.385  1.00 81.57 ? 293 ALA B N   1 
ATOM 3231 C CA  . ALA B 1 293 ? 64.137  98.850  76.953  1.00 78.05 ? 293 ALA B CA  1 
ATOM 3232 C C   . ALA B 1 293 ? 64.684  97.606  76.225  1.00 77.24 ? 293 ALA B C   1 
ATOM 3233 O O   . ALA B 1 293 ? 63.952  96.968  75.464  1.00 75.21 ? 293 ALA B O   1 
ATOM 3234 C CB  . ALA B 1 293 ? 64.709  100.153 76.378  1.00 74.91 ? 293 ALA B CB  1 
ATOM 3235 N N   . LYS B 1 294 ? 65.924  97.205  76.505  1.00 81.90 ? 294 LYS B N   1 
ATOM 3236 C CA  . LYS B 1 294 ? 66.518  96.006  75.908  1.00 81.32 ? 294 LYS B CA  1 
ATOM 3237 C C   . LYS B 1 294 ? 65.788  94.725  76.296  1.00 81.09 ? 294 LYS B C   1 
ATOM 3238 O O   . LYS B 1 294 ? 65.567  93.886  75.433  1.00 79.33 ? 294 LYS B O   1 
ATOM 3239 C CB  . LYS B 1 294 ? 68.014  95.904  76.266  1.00 80.59 ? 294 LYS B CB  1 
ATOM 3240 C CG  . LYS B 1 294 ? 68.871  96.994  75.595  1.00 77.38 ? 294 LYS B CG  1 
ATOM 3241 C CD  . LYS B 1 294 ? 68.862  96.925  74.075  1.00 75.46 ? 294 LYS B CD  1 
ATOM 3242 C CE  . LYS B 1 294 ? 69.610  98.115  73.497  1.00 71.86 ? 294 LYS B CE  1 
ATOM 3243 N NZ  . LYS B 1 294 ? 69.777  98.012  72.025  1.00 67.48 ? 294 LYS B NZ  1 
ATOM 3244 N N   . ALA B 1 295 ? 65.364  94.606  77.535  1.00 83.94 ? 295 ALA B N   1 
ATOM 3245 C CA  . ALA B 1 295 ? 64.597  93.460  78.013  1.00 82.54 ? 295 ALA B CA  1 
ATOM 3246 C C   . ALA B 1 295 ? 63.250  93.320  77.294  1.00 79.93 ? 295 ALA B C   1 
ATOM 3247 O O   . ALA B 1 295 ? 62.897  92.232  76.856  1.00 76.31 ? 295 ALA B O   1 
ATOM 3248 C CB  . ALA B 1 295 ? 64.411  93.615  79.527  1.00 83.33 ? 295 ALA B CB  1 
ATOM 3249 N N   . ARG B 1 296 ? 62.513  94.435  77.093  1.00 75.48 ? 296 ARG B N   1 
ATOM 3250 C CA  . ARG B 1 296 ? 61.252  94.427  76.340  1.00 71.45 ? 296 ARG B CA  1 
ATOM 3251 C C   . ARG B 1 296 ? 61.430  94.003  74.883  1.00 69.81 ? 296 ARG B C   1 
ATOM 3252 O O   . ARG B 1 296 ? 60.509  93.432  74.307  1.00 64.89 ? 296 ARG B O   1 
ATOM 3253 C CB  . ARG B 1 296 ? 60.621  95.825  76.363  1.00 67.71 ? 296 ARG B CB  1 
ATOM 3254 C CG  . ARG B 1 296 ? 60.016  96.180  77.722  1.00 60.97 ? 296 ARG B CG  1 
ATOM 3255 C CD  . ARG B 1 296 ? 59.519  97.624  77.650  1.00 57.31 ? 296 ARG B CD  1 
ATOM 3256 N NE  . ARG B 1 296 ? 58.958  98.069  78.937  1.00 50.64 ? 296 ARG B NE  1 
ATOM 3257 C CZ  . ARG B 1 296 ? 58.368  99.238  79.143  1.00 45.07 ? 296 ARG B CZ  1 
ATOM 3258 N NH1 . ARG B 1 296 ? 58.234  100.112 78.183  1.00 41.97 ? 296 ARG B NH1 1 
ATOM 3259 N NH2 . ARG B 1 296 ? 57.911  99.537  80.321  1.00 39.79 ? 296 ARG B NH2 1 
ATOM 3260 N N   . ASN B 1 297 ? 62.584  94.292  74.296  1.00 69.67 ? 297 ASN B N   1 
ATOM 3261 C CA  . ASN B 1 297 ? 62.880  93.960  72.901  1.00 66.01 ? 297 ASN B CA  1 
ATOM 3262 C C   . ASN B 1 297 ? 63.463  92.552  72.729  1.00 65.20 ? 297 ASN B C   1 
ATOM 3263 O O   . ASN B 1 297 ? 63.704  92.109  71.608  1.00 60.87 ? 297 ASN B O   1 
ATOM 3264 C CB  . ASN B 1 297 ? 63.791  95.049  72.310  1.00 61.62 ? 297 ASN B CB  1 
ATOM 3265 C CG  . ASN B 1 297 ? 63.319  95.527  70.947  1.00 55.80 ? 297 ASN B CG  1 
ATOM 3266 O OD1 . ASN B 1 297 ? 62.238  95.233  70.478  1.00 50.91 ? 297 ASN B OD1 1 
ATOM 3267 N ND2 . ASN B 1 297 ? 64.130  96.328  70.278  1.00 49.90 ? 297 ASN B ND2 1 
ATOM 3268 N N   . TRP B 1 298 ? 63.701  91.872  73.841  1.00 67.75 ? 298 TRP B N   1 
ATOM 3269 C CA  . TRP B 1 298 ? 64.272  90.530  73.868  1.00 65.26 ? 298 TRP B CA  1 
ATOM 3270 C C   . TRP B 1 298 ? 63.169  89.470  73.690  1.00 63.72 ? 298 TRP B C   1 
ATOM 3271 O O   . TRP B 1 298 ? 62.833  88.722  74.597  1.00 59.44 ? 298 TRP B O   1 
ATOM 3272 C CB  . TRP B 1 298 ? 65.113  90.378  75.134  1.00 62.76 ? 298 TRP B CB  1 
ATOM 3273 C CG  . TRP B 1 298 ? 66.100  89.257  75.093  1.00 62.66 ? 298 TRP B CG  1 
ATOM 3274 C CD1 . TRP B 1 298 ? 67.178  89.173  74.282  1.00 55.45 ? 298 TRP B CD1 1 
ATOM 3275 C CD2 . TRP B 1 298 ? 66.126  88.061  75.920  1.00 58.82 ? 298 TRP B CD2 1 
ATOM 3276 N NE1 . TRP B 1 298 ? 67.881  87.999  74.552  1.00 54.36 ? 298 TRP B NE1 1 
ATOM 3277 C CE2 . TRP B 1 298 ? 67.259  87.296  75.553  1.00 57.86 ? 298 TRP B CE2 1 
ATOM 3278 C CE3 . TRP B 1 298 ? 65.299  87.570  76.947  1.00 57.32 ? 298 TRP B CE3 1 
ATOM 3279 C CZ2 . TRP B 1 298 ? 67.577  86.074  76.177  1.00 55.55 ? 298 TRP B CZ2 1 
ATOM 3280 C CZ3 . TRP B 1 298 ? 65.611  86.348  77.569  1.00 51.22 ? 298 TRP B CZ3 1 
ATOM 3281 C CH2 . TRP B 1 298 ? 66.730  85.606  77.189  1.00 51.50 ? 298 TRP B CH2 1 
ATOM 3282 N N   . ASN B 1 299 ? 62.594  89.465  72.489  1.00 59.27 ? 299 ASN B N   1 
ATOM 3283 C CA  . ASN B 1 299 ? 61.739  88.368  72.040  1.00 56.63 ? 299 ASN B CA  1 
ATOM 3284 C C   . ASN B 1 299 ? 62.648  87.242  71.537  1.00 56.63 ? 299 ASN B C   1 
ATOM 3285 O O   . ASN B 1 299 ? 63.172  87.320  70.422  1.00 51.04 ? 299 ASN B O   1 
ATOM 3286 C CB  . ASN B 1 299 ? 60.752  88.858  70.970  1.00 49.50 ? 299 ASN B CB  1 
ATOM 3287 C CG  . ASN B 1 299 ? 59.617  89.712  71.526  1.00 43.58 ? 299 ASN B CG  1 
ATOM 3288 O OD1 . ASN B 1 299 ? 59.305  89.727  72.699  1.00 39.51 ? 299 ASN B OD1 1 
ATOM 3289 N ND2 . ASN B 1 299 ? 58.928  90.423  70.658  1.00 37.67 ? 299 ASN B ND2 1 
ATOM 3290 N N   . PHE B 1 300 ? 62.854  86.234  72.372  1.00 55.16 ? 300 PHE B N   1 
ATOM 3291 C CA  . PHE B 1 300 ? 63.331  84.915  71.981  1.00 51.50 ? 300 PHE B CA  1 
ATOM 3292 C C   . PHE B 1 300 ? 62.148  84.019  71.661  1.00 47.48 ? 300 PHE B C   1 
ATOM 3293 O O   . PHE B 1 300 ? 61.107  84.115  72.343  1.00 42.62 ? 300 PHE B O   1 
ATOM 3294 C CB  . PHE B 1 300 ? 64.253  84.319  73.045  1.00 47.93 ? 300 PHE B CB  1 
ATOM 3295 C CG  . PHE B 1 300 ? 65.662  84.859  72.977  1.00 45.36 ? 300 PHE B CG  1 
ATOM 3296 C CD1 . PHE B 1 300 ? 66.556  84.373  72.010  1.00 42.86 ? 300 PHE B CD1 1 
ATOM 3297 C CD2 . PHE B 1 300 ? 66.092  85.842  73.880  1.00 41.45 ? 300 PHE B CD2 1 
ATOM 3298 C CE1 . PHE B 1 300 ? 67.863  84.862  71.943  1.00 39.05 ? 300 PHE B CE1 1 
ATOM 3299 C CE2 . PHE B 1 300 ? 67.407  86.328  73.816  1.00 41.61 ? 300 PHE B CE2 1 
ATOM 3300 C CZ  . PHE B 1 300 ? 68.296  85.837  72.845  1.00 38.06 ? 300 PHE B CZ  1 
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