data_9H94
# 
_entry.id   9H94 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9H94         pdb_00009h94 10.2210/pdb9h94/pdb 
WWPDB D_1292142778 ?            ?                   
EMDB  EMD-51952    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-04-02 ? 
2 'EM metadata'     1 0 2025-04-02 ? 
3 FSC               1 0 2025-04-02 ? 
4 'Half map'        1 0 2025-04-02 1 
5 'Half map'        1 0 2025-04-02 2 
6 Image             1 0 2025-04-02 ? 
7 'Primary map'     1 0 2025-04-02 ? 
8 'Structure model' 1 1 2025-04-09 ? 
# 
loop_
_pdbx_audit_revision_details.ordinal 
_pdbx_audit_revision_details.revision_ordinal 
_pdbx_audit_revision_details.data_content_type 
_pdbx_audit_revision_details.provider 
_pdbx_audit_revision_details.type 
_pdbx_audit_revision_details.description 
_pdbx_audit_revision_details.details 
1 1 'Structure model' repository 'Initial release' ? ? 
2 2 'EM metadata'     repository 'Initial release' ? ? 
3 3 FSC               repository 'Initial release' ? ? 
4 4 'Half map'        repository 'Initial release' ? ? 
5 5 'Half map'        repository 'Initial release' ? ? 
6 6 Image             repository 'Initial release' ? ? 
7 7 'Primary map'     repository 'Initial release' ? ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 8 'Structure model' 'Data collection'     
2 8 'Structure model' 'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 8 'Structure model' citation        
2 8 'Structure model' citation_author 
3 8 'Structure model' em_admin        
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  8 'Structure model' '_citation.country'                 
2  8 'Structure model' '_citation.journal_abbrev'          
3  8 'Structure model' '_citation.journal_id_CSD'          
4  8 'Structure model' '_citation.journal_id_ISSN'         
5  8 'Structure model' '_citation.journal_volume'          
6  8 'Structure model' '_citation.page_first'              
7  8 'Structure model' '_citation.page_last'               
8  8 'Structure model' '_citation.pdbx_database_id_DOI'    
9  8 'Structure model' '_citation.pdbx_database_id_PubMed' 
10 8 'Structure model' '_citation.title'                   
11 8 'Structure model' '_citation.year'                    
12 8 'Structure model' '_em_admin.last_update'             
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9H94 
_pdbx_database_status.recvd_initial_deposition_date   2024-10-29 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        
'Poliovirus type 2 (strain MEF-1) stabilised virus-like particle (PV2 SC5a) from a yeast expression system.' 
_pdbx_database_related.db_id          EMD-51952 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              dave.stuart@strubi.ox.ac.uk 
_pdbx_contact_author.name_first         David 
_pdbx_contact_author.name_last          Stuart 
_pdbx_contact_author.name_mi            I. 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-3426-4210 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Bahar, M.W.'      1 0000-0002-2350-2682 
'Sherry, L.'       2 0000-0002-4367-772X 
'Stonehouse, N.J.' 3 0000-0003-1146-5519 
'Rowlands, D.J.'   4 0000-0002-4742-9272 
'Fry, E.E.'        5 0000-0001-9754-5303 
'Stuart, D.I.'     6 0000-0002-3426-4210 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Npj Vaccines' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2059-0105 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            10 
_citation.language                  ? 
_citation.page_first                64 
_citation.page_last                 64 
_citation.title                     
'Production of an immunogenic trivalent poliovirus virus-like particle vaccine candidate in yeast using controlled fermentation.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41541-025-01111-2 
_citation.pdbx_database_id_PubMed   40164627 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Sherry, L.'       1  ? 
primary 'Grehan, K.'       2  ? 
primary 'Bahar, M.W.'      3  ? 
primary 'Swanson, J.J.'    4  ? 
primary 'Fox, H.'          5  ? 
primary 'Matthews, S.'     6  ? 
primary 'Carlyle, S.'      7  ? 
primary 'Qin, L.'          8  ? 
primary 'Porta, C.'        9  ? 
primary 'Wilkinson, S.'    10 ? 
primary 'Robb, S.'         11 ? 
primary 'Clark, N.'        12 ? 
primary 'Liddell, J.'      13 ? 
primary 'Fry, E.E.'        14 ? 
primary 'Stuart, D.I.'     15 ? 
primary 'Macadam, A.J.'    16 ? 
primary 'Rowlands, D.J.'   17 ? 
primary 'Stonehouse, N.J.' 18 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Capsid protein VP1' 33073.246 1   ? 'VP1 T41I, VP1 F134L, VP1 Y159F' ? ? 
2 polymer     man 'Capsid protein VP0' 37456.855 1   ? ?                                ? ? 
3 polymer     man 'Capsid protein VP3' 26491.340 1   ? 'VP3 L85F, VP3 Q178L'            ? ? 
4 non-polymer syn SPHINGOSINE          299.492   1   ? ?                                ? ? 
5 water       nat water                18.015    194 ? ?                                ? ? 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;GLGDLIEGVVEGVTRNALTPLTPANNLPDTQSSGPAHSKEIPALTAVETGATNPLVPSDTVQTRHVIQKRTRSESTVESF
FARGACVAIIEVDNDAPTKRASKLFSVWKITYKDTVQLRRKLEFFTYSRFDMELTFVVTSNYTDANNGHALNQVYQIMFI
PPGAPIPGKWNDYTWQTSSNPSVFYTYGAPPARISVPYVGIANAYSHFYDGFAKVPLAGQASTEGDSLYGAASLNDFGSL
AVRVVNDHNPTKLTSKIRVYMKPKHVRVWCPRPPRAVPYYGPGVDYKDGLAPLPEKGLTTY
;
;GLGDLIEGVVEGVTRNALTPLTPANNLPDTQSSGPAHSKEIPALTAVETGATNPLVPSDTVQTRHVIQKRTRSESTVESF
FARGACVAIIEVDNDAPTKRASKLFSVWKITYKDTVQLRRKLEFFTYSRFDMELTFVVTSNYTDANNGHALNQVYQIMFI
PPGAPIPGKWNDYTWQTSSNPSVFYTYGAPPARISVPYVGIANAYSHFYDGFAKVPLAGQASTEGDSLYGAASLNDFGSL
AVRVVNDHNPTKLTSKIRVYMKPKHVRVWCPRPPRAVPYYGPGVDYKDGLAPLPEKGLTTY
;
A ? 
2 'polypeptide(L)' no no 
;MGAQVSSQKVGAHENSNRAYGGSTINYTTINYYRDSASNAASKQDFAQDPSKFTEPIKDVLIKTAPTLNSPNIEACGYSD
RVMQLTLGNSTITTQEAANSVVAYGRWPEYIKDSEANPVDQPTEPDVAACRFYTLDTVTWRKESRGWWWKLPDALKDMGL
FGQNMFYHYLGRAGYTVHVQCNASKFHQGALGVFAVPEMCLAGDSTTHMFTKYENANPGEKGGEFKGSFTLDTNATNPAR
NFCPVDYLFGSGVLAGNAFVYPHQIINLRTNNCATLVLPYVNSLSIDSMTKHNNWGIAILPLAPLDFATESSTEIPITLT
IAPMCCEFNGLRNITVPRTQ
;
;MGAQVSSQKVGAHENSNRAYGGSTINYTTINYYRDSASNAASKQDFAQDPSKFTEPIKDVLIKTAPTLNSPNIEACGYSD
RVMQLTLGNSTITTQEAANSVVAYGRWPEYIKDSEANPVDQPTEPDVAACRFYTLDTVTWRKESRGWWWKLPDALKDMGL
FGQNMFYHYLGRAGYTVHVQCNASKFHQGALGVFAVPEMCLAGDSTTHMFTKYENANPGEKGGEFKGSFTLDTNATNPAR
NFCPVDYLFGSGVLAGNAFVYPHQIINLRTNNCATLVLPYVNSLSIDSMTKHNNWGIAILPLAPLDFATESSTEIPITLT
IAPMCCEFNGLRNITVPRTQ
;
B ? 
3 'polypeptide(L)' no no 
;GLPVLNTPGSNQYLTADNYQSPCAIPEFDVTPPIDIPGEVRNMMELAEIDTMIPLNLTNQRKNTMDMYRVELNDAAHSDT
PILCFSLSPASDPRLAHTMLGEILNYYTHWAGSLKFTFLFCGSMMATGKLLVSYAPPGAEAPKSRKEAMLGTHVIWDIGL
QSSCTMVVPWISNTTYRLTINDSFTEGGYISMFYQTRVVVPLSTPRKMDILGFVSACNDFSVRLLRDTTHISQEAMPQ
;
;GLPVLNTPGSNQYLTADNYQSPCAIPEFDVTPPIDIPGEVRNMMELAEIDTMIPLNLTNQRKNTMDMYRVELNDAAHSDT
PILCFSLSPASDPRLAHTMLGEILNYYTHWAGSLKFTFLFCGSMMATGKLLVSYAPPGAEAPKSRKEAMLGTHVIWDIGL
QSSCTMVVPWISNTTYRLTINDSFTEGGYISMFYQTRVVVPLSTPRKMDILGFVSACNDFSVRLLRDTTHISQEAMPQ
;
C ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
4 SPHINGOSINE SPH 
5 water       HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   LEU n 
1 3   GLY n 
1 4   ASP n 
1 5   LEU n 
1 6   ILE n 
1 7   GLU n 
1 8   GLY n 
1 9   VAL n 
1 10  VAL n 
1 11  GLU n 
1 12  GLY n 
1 13  VAL n 
1 14  THR n 
1 15  ARG n 
1 16  ASN n 
1 17  ALA n 
1 18  LEU n 
1 19  THR n 
1 20  PRO n 
1 21  LEU n 
1 22  THR n 
1 23  PRO n 
1 24  ALA n 
1 25  ASN n 
1 26  ASN n 
1 27  LEU n 
1 28  PRO n 
1 29  ASP n 
1 30  THR n 
1 31  GLN n 
1 32  SER n 
1 33  SER n 
1 34  GLY n 
1 35  PRO n 
1 36  ALA n 
1 37  HIS n 
1 38  SER n 
1 39  LYS n 
1 40  GLU n 
1 41  ILE n 
1 42  PRO n 
1 43  ALA n 
1 44  LEU n 
1 45  THR n 
1 46  ALA n 
1 47  VAL n 
1 48  GLU n 
1 49  THR n 
1 50  GLY n 
1 51  ALA n 
1 52  THR n 
1 53  ASN n 
1 54  PRO n 
1 55  LEU n 
1 56  VAL n 
1 57  PRO n 
1 58  SER n 
1 59  ASP n 
1 60  THR n 
1 61  VAL n 
1 62  GLN n 
1 63  THR n 
1 64  ARG n 
1 65  HIS n 
1 66  VAL n 
1 67  ILE n 
1 68  GLN n 
1 69  LYS n 
1 70  ARG n 
1 71  THR n 
1 72  ARG n 
1 73  SER n 
1 74  GLU n 
1 75  SER n 
1 76  THR n 
1 77  VAL n 
1 78  GLU n 
1 79  SER n 
1 80  PHE n 
1 81  PHE n 
1 82  ALA n 
1 83  ARG n 
1 84  GLY n 
1 85  ALA n 
1 86  CYS n 
1 87  VAL n 
1 88  ALA n 
1 89  ILE n 
1 90  ILE n 
1 91  GLU n 
1 92  VAL n 
1 93  ASP n 
1 94  ASN n 
1 95  ASP n 
1 96  ALA n 
1 97  PRO n 
1 98  THR n 
1 99  LYS n 
1 100 ARG n 
1 101 ALA n 
1 102 SER n 
1 103 LYS n 
1 104 LEU n 
1 105 PHE n 
1 106 SER n 
1 107 VAL n 
1 108 TRP n 
1 109 LYS n 
1 110 ILE n 
1 111 THR n 
1 112 TYR n 
1 113 LYS n 
1 114 ASP n 
1 115 THR n 
1 116 VAL n 
1 117 GLN n 
1 118 LEU n 
1 119 ARG n 
1 120 ARG n 
1 121 LYS n 
1 122 LEU n 
1 123 GLU n 
1 124 PHE n 
1 125 PHE n 
1 126 THR n 
1 127 TYR n 
1 128 SER n 
1 129 ARG n 
1 130 PHE n 
1 131 ASP n 
1 132 MET n 
1 133 GLU n 
1 134 LEU n 
1 135 THR n 
1 136 PHE n 
1 137 VAL n 
1 138 VAL n 
1 139 THR n 
1 140 SER n 
1 141 ASN n 
1 142 TYR n 
1 143 THR n 
1 144 ASP n 
1 145 ALA n 
1 146 ASN n 
1 147 ASN n 
1 148 GLY n 
1 149 HIS n 
1 150 ALA n 
1 151 LEU n 
1 152 ASN n 
1 153 GLN n 
1 154 VAL n 
1 155 TYR n 
1 156 GLN n 
1 157 ILE n 
1 158 MET n 
1 159 PHE n 
1 160 ILE n 
1 161 PRO n 
1 162 PRO n 
1 163 GLY n 
1 164 ALA n 
1 165 PRO n 
1 166 ILE n 
1 167 PRO n 
1 168 GLY n 
1 169 LYS n 
1 170 TRP n 
1 171 ASN n 
1 172 ASP n 
1 173 TYR n 
1 174 THR n 
1 175 TRP n 
1 176 GLN n 
1 177 THR n 
1 178 SER n 
1 179 SER n 
1 180 ASN n 
1 181 PRO n 
1 182 SER n 
1 183 VAL n 
1 184 PHE n 
1 185 TYR n 
1 186 THR n 
1 187 TYR n 
1 188 GLY n 
1 189 ALA n 
1 190 PRO n 
1 191 PRO n 
1 192 ALA n 
1 193 ARG n 
1 194 ILE n 
1 195 SER n 
1 196 VAL n 
1 197 PRO n 
1 198 TYR n 
1 199 VAL n 
1 200 GLY n 
1 201 ILE n 
1 202 ALA n 
1 203 ASN n 
1 204 ALA n 
1 205 TYR n 
1 206 SER n 
1 207 HIS n 
1 208 PHE n 
1 209 TYR n 
1 210 ASP n 
1 211 GLY n 
1 212 PHE n 
1 213 ALA n 
1 214 LYS n 
1 215 VAL n 
1 216 PRO n 
1 217 LEU n 
1 218 ALA n 
1 219 GLY n 
1 220 GLN n 
1 221 ALA n 
1 222 SER n 
1 223 THR n 
1 224 GLU n 
1 225 GLY n 
1 226 ASP n 
1 227 SER n 
1 228 LEU n 
1 229 TYR n 
1 230 GLY n 
1 231 ALA n 
1 232 ALA n 
1 233 SER n 
1 234 LEU n 
1 235 ASN n 
1 236 ASP n 
1 237 PHE n 
1 238 GLY n 
1 239 SER n 
1 240 LEU n 
1 241 ALA n 
1 242 VAL n 
1 243 ARG n 
1 244 VAL n 
1 245 VAL n 
1 246 ASN n 
1 247 ASP n 
1 248 HIS n 
1 249 ASN n 
1 250 PRO n 
1 251 THR n 
1 252 LYS n 
1 253 LEU n 
1 254 THR n 
1 255 SER n 
1 256 LYS n 
1 257 ILE n 
1 258 ARG n 
1 259 VAL n 
1 260 TYR n 
1 261 MET n 
1 262 LYS n 
1 263 PRO n 
1 264 LYS n 
1 265 HIS n 
1 266 VAL n 
1 267 ARG n 
1 268 VAL n 
1 269 TRP n 
1 270 CYS n 
1 271 PRO n 
1 272 ARG n 
1 273 PRO n 
1 274 PRO n 
1 275 ARG n 
1 276 ALA n 
1 277 VAL n 
1 278 PRO n 
1 279 TYR n 
1 280 TYR n 
1 281 GLY n 
1 282 PRO n 
1 283 GLY n 
1 284 VAL n 
1 285 ASP n 
1 286 TYR n 
1 287 LYS n 
1 288 ASP n 
1 289 GLY n 
1 290 LEU n 
1 291 ALA n 
1 292 PRO n 
1 293 LEU n 
1 294 PRO n 
1 295 GLU n 
1 296 LYS n 
1 297 GLY n 
1 298 LEU n 
1 299 THR n 
1 300 THR n 
1 301 TYR n 
2 1   MET n 
2 2   GLY n 
2 3   ALA n 
2 4   GLN n 
2 5   VAL n 
2 6   SER n 
2 7   SER n 
2 8   GLN n 
2 9   LYS n 
2 10  VAL n 
2 11  GLY n 
2 12  ALA n 
2 13  HIS n 
2 14  GLU n 
2 15  ASN n 
2 16  SER n 
2 17  ASN n 
2 18  ARG n 
2 19  ALA n 
2 20  TYR n 
2 21  GLY n 
2 22  GLY n 
2 23  SER n 
2 24  THR n 
2 25  ILE n 
2 26  ASN n 
2 27  TYR n 
2 28  THR n 
2 29  THR n 
2 30  ILE n 
2 31  ASN n 
2 32  TYR n 
2 33  TYR n 
2 34  ARG n 
2 35  ASP n 
2 36  SER n 
2 37  ALA n 
2 38  SER n 
2 39  ASN n 
2 40  ALA n 
2 41  ALA n 
2 42  SER n 
2 43  LYS n 
2 44  GLN n 
2 45  ASP n 
2 46  PHE n 
2 47  ALA n 
2 48  GLN n 
2 49  ASP n 
2 50  PRO n 
2 51  SER n 
2 52  LYS n 
2 53  PHE n 
2 54  THR n 
2 55  GLU n 
2 56  PRO n 
2 57  ILE n 
2 58  LYS n 
2 59  ASP n 
2 60  VAL n 
2 61  LEU n 
2 62  ILE n 
2 63  LYS n 
2 64  THR n 
2 65  ALA n 
2 66  PRO n 
2 67  THR n 
2 68  LEU n 
2 69  ASN n 
2 70  SER n 
2 71  PRO n 
2 72  ASN n 
2 73  ILE n 
2 74  GLU n 
2 75  ALA n 
2 76  CYS n 
2 77  GLY n 
2 78  TYR n 
2 79  SER n 
2 80  ASP n 
2 81  ARG n 
2 82  VAL n 
2 83  MET n 
2 84  GLN n 
2 85  LEU n 
2 86  THR n 
2 87  LEU n 
2 88  GLY n 
2 89  ASN n 
2 90  SER n 
2 91  THR n 
2 92  ILE n 
2 93  THR n 
2 94  THR n 
2 95  GLN n 
2 96  GLU n 
2 97  ALA n 
2 98  ALA n 
2 99  ASN n 
2 100 SER n 
2 101 VAL n 
2 102 VAL n 
2 103 ALA n 
2 104 TYR n 
2 105 GLY n 
2 106 ARG n 
2 107 TRP n 
2 108 PRO n 
2 109 GLU n 
2 110 TYR n 
2 111 ILE n 
2 112 LYS n 
2 113 ASP n 
2 114 SER n 
2 115 GLU n 
2 116 ALA n 
2 117 ASN n 
2 118 PRO n 
2 119 VAL n 
2 120 ASP n 
2 121 GLN n 
2 122 PRO n 
2 123 THR n 
2 124 GLU n 
2 125 PRO n 
2 126 ASP n 
2 127 VAL n 
2 128 ALA n 
2 129 ALA n 
2 130 CYS n 
2 131 ARG n 
2 132 PHE n 
2 133 TYR n 
2 134 THR n 
2 135 LEU n 
2 136 ASP n 
2 137 THR n 
2 138 VAL n 
2 139 THR n 
2 140 TRP n 
2 141 ARG n 
2 142 LYS n 
2 143 GLU n 
2 144 SER n 
2 145 ARG n 
2 146 GLY n 
2 147 TRP n 
2 148 TRP n 
2 149 TRP n 
2 150 LYS n 
2 151 LEU n 
2 152 PRO n 
2 153 ASP n 
2 154 ALA n 
2 155 LEU n 
2 156 LYS n 
2 157 ASP n 
2 158 MET n 
2 159 GLY n 
2 160 LEU n 
2 161 PHE n 
2 162 GLY n 
2 163 GLN n 
2 164 ASN n 
2 165 MET n 
2 166 PHE n 
2 167 TYR n 
2 168 HIS n 
2 169 TYR n 
2 170 LEU n 
2 171 GLY n 
2 172 ARG n 
2 173 ALA n 
2 174 GLY n 
2 175 TYR n 
2 176 THR n 
2 177 VAL n 
2 178 HIS n 
2 179 VAL n 
2 180 GLN n 
2 181 CYS n 
2 182 ASN n 
2 183 ALA n 
2 184 SER n 
2 185 LYS n 
2 186 PHE n 
2 187 HIS n 
2 188 GLN n 
2 189 GLY n 
2 190 ALA n 
2 191 LEU n 
2 192 GLY n 
2 193 VAL n 
2 194 PHE n 
2 195 ALA n 
2 196 VAL n 
2 197 PRO n 
2 198 GLU n 
2 199 MET n 
2 200 CYS n 
2 201 LEU n 
2 202 ALA n 
2 203 GLY n 
2 204 ASP n 
2 205 SER n 
2 206 THR n 
2 207 THR n 
2 208 HIS n 
2 209 MET n 
2 210 PHE n 
2 211 THR n 
2 212 LYS n 
2 213 TYR n 
2 214 GLU n 
2 215 ASN n 
2 216 ALA n 
2 217 ASN n 
2 218 PRO n 
2 219 GLY n 
2 220 GLU n 
2 221 LYS n 
2 222 GLY n 
2 223 GLY n 
2 224 GLU n 
2 225 PHE n 
2 226 LYS n 
2 227 GLY n 
2 228 SER n 
2 229 PHE n 
2 230 THR n 
2 231 LEU n 
2 232 ASP n 
2 233 THR n 
2 234 ASN n 
2 235 ALA n 
2 236 THR n 
2 237 ASN n 
2 238 PRO n 
2 239 ALA n 
2 240 ARG n 
2 241 ASN n 
2 242 PHE n 
2 243 CYS n 
2 244 PRO n 
2 245 VAL n 
2 246 ASP n 
2 247 TYR n 
2 248 LEU n 
2 249 PHE n 
2 250 GLY n 
2 251 SER n 
2 252 GLY n 
2 253 VAL n 
2 254 LEU n 
2 255 ALA n 
2 256 GLY n 
2 257 ASN n 
2 258 ALA n 
2 259 PHE n 
2 260 VAL n 
2 261 TYR n 
2 262 PRO n 
2 263 HIS n 
2 264 GLN n 
2 265 ILE n 
2 266 ILE n 
2 267 ASN n 
2 268 LEU n 
2 269 ARG n 
2 270 THR n 
2 271 ASN n 
2 272 ASN n 
2 273 CYS n 
2 274 ALA n 
2 275 THR n 
2 276 LEU n 
2 277 VAL n 
2 278 LEU n 
2 279 PRO n 
2 280 TYR n 
2 281 VAL n 
2 282 ASN n 
2 283 SER n 
2 284 LEU n 
2 285 SER n 
2 286 ILE n 
2 287 ASP n 
2 288 SER n 
2 289 MET n 
2 290 THR n 
2 291 LYS n 
2 292 HIS n 
2 293 ASN n 
2 294 ASN n 
2 295 TRP n 
2 296 GLY n 
2 297 ILE n 
2 298 ALA n 
2 299 ILE n 
2 300 LEU n 
2 301 PRO n 
2 302 LEU n 
2 303 ALA n 
2 304 PRO n 
2 305 LEU n 
2 306 ASP n 
2 307 PHE n 
2 308 ALA n 
2 309 THR n 
2 310 GLU n 
2 311 SER n 
2 312 SER n 
2 313 THR n 
2 314 GLU n 
2 315 ILE n 
2 316 PRO n 
2 317 ILE n 
2 318 THR n 
2 319 LEU n 
2 320 THR n 
2 321 ILE n 
2 322 ALA n 
2 323 PRO n 
2 324 MET n 
2 325 CYS n 
2 326 CYS n 
2 327 GLU n 
2 328 PHE n 
2 329 ASN n 
2 330 GLY n 
2 331 LEU n 
2 332 ARG n 
2 333 ASN n 
2 334 ILE n 
2 335 THR n 
2 336 VAL n 
2 337 PRO n 
2 338 ARG n 
2 339 THR n 
2 340 GLN n 
3 1   GLY n 
3 2   LEU n 
3 3   PRO n 
3 4   VAL n 
3 5   LEU n 
3 6   ASN n 
3 7   THR n 
3 8   PRO n 
3 9   GLY n 
3 10  SER n 
3 11  ASN n 
3 12  GLN n 
3 13  TYR n 
3 14  LEU n 
3 15  THR n 
3 16  ALA n 
3 17  ASP n 
3 18  ASN n 
3 19  TYR n 
3 20  GLN n 
3 21  SER n 
3 22  PRO n 
3 23  CYS n 
3 24  ALA n 
3 25  ILE n 
3 26  PRO n 
3 27  GLU n 
3 28  PHE n 
3 29  ASP n 
3 30  VAL n 
3 31  THR n 
3 32  PRO n 
3 33  PRO n 
3 34  ILE n 
3 35  ASP n 
3 36  ILE n 
3 37  PRO n 
3 38  GLY n 
3 39  GLU n 
3 40  VAL n 
3 41  ARG n 
3 42  ASN n 
3 43  MET n 
3 44  MET n 
3 45  GLU n 
3 46  LEU n 
3 47  ALA n 
3 48  GLU n 
3 49  ILE n 
3 50  ASP n 
3 51  THR n 
3 52  MET n 
3 53  ILE n 
3 54  PRO n 
3 55  LEU n 
3 56  ASN n 
3 57  LEU n 
3 58  THR n 
3 59  ASN n 
3 60  GLN n 
3 61  ARG n 
3 62  LYS n 
3 63  ASN n 
3 64  THR n 
3 65  MET n 
3 66  ASP n 
3 67  MET n 
3 68  TYR n 
3 69  ARG n 
3 70  VAL n 
3 71  GLU n 
3 72  LEU n 
3 73  ASN n 
3 74  ASP n 
3 75  ALA n 
3 76  ALA n 
3 77  HIS n 
3 78  SER n 
3 79  ASP n 
3 80  THR n 
3 81  PRO n 
3 82  ILE n 
3 83  LEU n 
3 84  CYS n 
3 85  PHE n 
3 86  SER n 
3 87  LEU n 
3 88  SER n 
3 89  PRO n 
3 90  ALA n 
3 91  SER n 
3 92  ASP n 
3 93  PRO n 
3 94  ARG n 
3 95  LEU n 
3 96  ALA n 
3 97  HIS n 
3 98  THR n 
3 99  MET n 
3 100 LEU n 
3 101 GLY n 
3 102 GLU n 
3 103 ILE n 
3 104 LEU n 
3 105 ASN n 
3 106 TYR n 
3 107 TYR n 
3 108 THR n 
3 109 HIS n 
3 110 TRP n 
3 111 ALA n 
3 112 GLY n 
3 113 SER n 
3 114 LEU n 
3 115 LYS n 
3 116 PHE n 
3 117 THR n 
3 118 PHE n 
3 119 LEU n 
3 120 PHE n 
3 121 CYS n 
3 122 GLY n 
3 123 SER n 
3 124 MET n 
3 125 MET n 
3 126 ALA n 
3 127 THR n 
3 128 GLY n 
3 129 LYS n 
3 130 LEU n 
3 131 LEU n 
3 132 VAL n 
3 133 SER n 
3 134 TYR n 
3 135 ALA n 
3 136 PRO n 
3 137 PRO n 
3 138 GLY n 
3 139 ALA n 
3 140 GLU n 
3 141 ALA n 
3 142 PRO n 
3 143 LYS n 
3 144 SER n 
3 145 ARG n 
3 146 LYS n 
3 147 GLU n 
3 148 ALA n 
3 149 MET n 
3 150 LEU n 
3 151 GLY n 
3 152 THR n 
3 153 HIS n 
3 154 VAL n 
3 155 ILE n 
3 156 TRP n 
3 157 ASP n 
3 158 ILE n 
3 159 GLY n 
3 160 LEU n 
3 161 GLN n 
3 162 SER n 
3 163 SER n 
3 164 CYS n 
3 165 THR n 
3 166 MET n 
3 167 VAL n 
3 168 VAL n 
3 169 PRO n 
3 170 TRP n 
3 171 ILE n 
3 172 SER n 
3 173 ASN n 
3 174 THR n 
3 175 THR n 
3 176 TYR n 
3 177 ARG n 
3 178 LEU n 
3 179 THR n 
3 180 ILE n 
3 181 ASN n 
3 182 ASP n 
3 183 SER n 
3 184 PHE n 
3 185 THR n 
3 186 GLU n 
3 187 GLY n 
3 188 GLY n 
3 189 TYR n 
3 190 ILE n 
3 191 SER n 
3 192 MET n 
3 193 PHE n 
3 194 TYR n 
3 195 GLN n 
3 196 THR n 
3 197 ARG n 
3 198 VAL n 
3 199 VAL n 
3 200 VAL n 
3 201 PRO n 
3 202 LEU n 
3 203 SER n 
3 204 THR n 
3 205 PRO n 
3 206 ARG n 
3 207 LYS n 
3 208 MET n 
3 209 ASP n 
3 210 ILE n 
3 211 LEU n 
3 212 GLY n 
3 213 PHE n 
3 214 VAL n 
3 215 SER n 
3 216 ALA n 
3 217 CYS n 
3 218 ASN n 
3 219 ASP n 
3 220 PHE n 
3 221 SER n 
3 222 VAL n 
3 223 ARG n 
3 224 LEU n 
3 225 LEU n 
3 226 ARG n 
3 227 ASP n 
3 228 THR n 
3 229 THR n 
3 230 HIS n 
3 231 ILE n 
3 232 SER n 
3 233 GLN n 
3 234 GLU n 
3 235 ALA n 
3 236 MET n 
3 237 PRO n 
3 238 GLN n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 301 ? ? ? ? MEF-1 ? ? ? ? 'Poliovirus 2' 12083 ? ? ? ? ? ? ? ? 'Komagataella pastoris' 4922 ? ? 
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 340 ? ? ? ? MEF-1 ? ? ? ? 'Poliovirus 2' 12083 ? ? ? ? ? ? ? ? 'Komagataella pastoris' 4922 ? ? 
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
3 1 sample 'Biological sequence' 1 238 ? ? ? ? MEF-1 ? ? ? ? 'Poliovirus 2' 12083 ? ? ? ? ? ? ? ? 'Komagataella pastoris' 4922 ? ? 
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
SPH non-polymer         . SPHINGOSINE     ? 'C18 H37 N O2'   299.492 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   1   ?   ?   ?   A . n 
A 1 2   LEU 2   2   ?   ?   ?   A . n 
A 1 3   GLY 3   3   ?   ?   ?   A . n 
A 1 4   ASP 4   4   ?   ?   ?   A . n 
A 1 5   LEU 5   5   ?   ?   ?   A . n 
A 1 6   ILE 6   6   ?   ?   ?   A . n 
A 1 7   GLU 7   7   ?   ?   ?   A . n 
A 1 8   GLY 8   8   ?   ?   ?   A . n 
A 1 9   VAL 9   9   ?   ?   ?   A . n 
A 1 10  VAL 10  10  ?   ?   ?   A . n 
A 1 11  GLU 11  11  ?   ?   ?   A . n 
A 1 12  GLY 12  12  ?   ?   ?   A . n 
A 1 13  VAL 13  13  ?   ?   ?   A . n 
A 1 14  THR 14  14  ?   ?   ?   A . n 
A 1 15  ARG 15  15  ?   ?   ?   A . n 
A 1 16  ASN 16  16  ?   ?   ?   A . n 
A 1 17  ALA 17  17  ?   ?   ?   A . n 
A 1 18  LEU 18  18  ?   ?   ?   A . n 
A 1 19  THR 19  19  ?   ?   ?   A . n 
A 1 20  PRO 20  20  ?   ?   ?   A . n 
A 1 21  LEU 21  21  ?   ?   ?   A . n 
A 1 22  THR 22  22  ?   ?   ?   A . n 
A 1 23  PRO 23  23  ?   ?   ?   A . n 
A 1 24  ALA 24  24  ?   ?   ?   A . n 
A 1 25  ASN 25  25  ?   ?   ?   A . n 
A 1 26  ASN 26  26  ?   ?   ?   A . n 
A 1 27  LEU 27  27  ?   ?   ?   A . n 
A 1 28  PRO 28  28  ?   ?   ?   A . n 
A 1 29  ASP 29  29  ?   ?   ?   A . n 
A 1 30  THR 30  30  ?   ?   ?   A . n 
A 1 31  GLN 31  31  ?   ?   ?   A . n 
A 1 32  SER 32  32  ?   ?   ?   A . n 
A 1 33  SER 33  33  ?   ?   ?   A . n 
A 1 34  GLY 34  34  ?   ?   ?   A . n 
A 1 35  PRO 35  35  ?   ?   ?   A . n 
A 1 36  ALA 36  36  ?   ?   ?   A . n 
A 1 37  HIS 37  37  ?   ?   ?   A . n 
A 1 38  SER 38  38  ?   ?   ?   A . n 
A 1 39  LYS 39  39  ?   ?   ?   A . n 
A 1 40  GLU 40  40  ?   ?   ?   A . n 
A 1 41  ILE 41  41  ?   ?   ?   A . n 
A 1 42  PRO 42  42  ?   ?   ?   A . n 
A 1 43  ALA 43  43  ?   ?   ?   A . n 
A 1 44  LEU 44  44  ?   ?   ?   A . n 
A 1 45  THR 45  45  ?   ?   ?   A . n 
A 1 46  ALA 46  46  ?   ?   ?   A . n 
A 1 47  VAL 47  47  ?   ?   ?   A . n 
A 1 48  GLU 48  48  ?   ?   ?   A . n 
A 1 49  THR 49  49  ?   ?   ?   A . n 
A 1 50  GLY 50  50  ?   ?   ?   A . n 
A 1 51  ALA 51  51  ?   ?   ?   A . n 
A 1 52  THR 52  52  ?   ?   ?   A . n 
A 1 53  ASN 53  53  ?   ?   ?   A . n 
A 1 54  PRO 54  54  ?   ?   ?   A . n 
A 1 55  LEU 55  55  ?   ?   ?   A . n 
A 1 56  VAL 56  56  ?   ?   ?   A . n 
A 1 57  PRO 57  57  ?   ?   ?   A . n 
A 1 58  SER 58  58  ?   ?   ?   A . n 
A 1 59  ASP 59  59  ?   ?   ?   A . n 
A 1 60  THR 60  60  ?   ?   ?   A . n 
A 1 61  VAL 61  61  ?   ?   ?   A . n 
A 1 62  GLN 62  62  62  GLN GLN A . n 
A 1 63  THR 63  63  63  THR THR A . n 
A 1 64  ARG 64  64  64  ARG ARG A . n 
A 1 65  HIS 65  65  65  HIS HIS A . n 
A 1 66  VAL 66  66  66  VAL VAL A . n 
A 1 67  ILE 67  67  67  ILE ILE A . n 
A 1 68  GLN 68  68  68  GLN GLN A . n 
A 1 69  LYS 69  69  69  LYS LYS A . n 
A 1 70  ARG 70  70  70  ARG ARG A . n 
A 1 71  THR 71  71  71  THR THR A . n 
A 1 72  ARG 72  72  72  ARG ARG A . n 
A 1 73  SER 73  73  73  SER SER A . n 
A 1 74  GLU 74  74  74  GLU GLU A . n 
A 1 75  SER 75  75  75  SER SER A . n 
A 1 76  THR 76  76  76  THR THR A . n 
A 1 77  VAL 77  77  77  VAL VAL A . n 
A 1 78  GLU 78  78  78  GLU GLU A . n 
A 1 79  SER 79  79  79  SER SER A . n 
A 1 80  PHE 80  80  80  PHE PHE A . n 
A 1 81  PHE 81  81  81  PHE PHE A . n 
A 1 82  ALA 82  82  82  ALA ALA A . n 
A 1 83  ARG 83  83  83  ARG ARG A . n 
A 1 84  GLY 84  84  84  GLY GLY A . n 
A 1 85  ALA 85  85  85  ALA ALA A . n 
A 1 86  CYS 86  86  86  CYS CYS A . n 
A 1 87  VAL 87  87  87  VAL VAL A . n 
A 1 88  ALA 88  88  88  ALA ALA A . n 
A 1 89  ILE 89  89  89  ILE ILE A . n 
A 1 90  ILE 90  90  90  ILE ILE A . n 
A 1 91  GLU 91  91  91  GLU GLU A . n 
A 1 92  VAL 92  92  92  VAL VAL A . n 
A 1 93  ASP 93  93  93  ASP ASP A . n 
A 1 94  ASN 94  94  94  ASN ASN A . n 
A 1 95  ASP 95  95  95  ASP ASP A . n 
A 1 96  ALA 96  96  96  ALA ALA A . n 
A 1 97  PRO 97  97  97  PRO PRO A . n 
A 1 98  THR 98  98  98  THR THR A . n 
A 1 99  LYS 99  99  99  LYS LYS A . n 
A 1 100 ARG 100 100 100 ARG ARG A . n 
A 1 101 ALA 101 101 101 ALA ALA A . n 
A 1 102 SER 102 102 102 SER SER A . n 
A 1 103 LYS 103 103 103 LYS LYS A . n 
A 1 104 LEU 104 104 104 LEU LEU A . n 
A 1 105 PHE 105 105 105 PHE PHE A . n 
A 1 106 SER 106 106 106 SER SER A . n 
A 1 107 VAL 107 107 107 VAL VAL A . n 
A 1 108 TRP 108 108 108 TRP TRP A . n 
A 1 109 LYS 109 109 109 LYS LYS A . n 
A 1 110 ILE 110 110 110 ILE ILE A . n 
A 1 111 THR 111 111 111 THR THR A . n 
A 1 112 TYR 112 112 112 TYR TYR A . n 
A 1 113 LYS 113 113 113 LYS LYS A . n 
A 1 114 ASP 114 114 114 ASP ASP A . n 
A 1 115 THR 115 115 115 THR THR A . n 
A 1 116 VAL 116 116 116 VAL VAL A . n 
A 1 117 GLN 117 117 117 GLN GLN A . n 
A 1 118 LEU 118 118 118 LEU LEU A . n 
A 1 119 ARG 119 119 119 ARG ARG A . n 
A 1 120 ARG 120 120 120 ARG ARG A . n 
A 1 121 LYS 121 121 121 LYS LYS A . n 
A 1 122 LEU 122 122 122 LEU LEU A . n 
A 1 123 GLU 123 123 123 GLU GLU A . n 
A 1 124 PHE 124 124 124 PHE PHE A . n 
A 1 125 PHE 125 125 125 PHE PHE A . n 
A 1 126 THR 126 126 126 THR THR A . n 
A 1 127 TYR 127 127 127 TYR TYR A . n 
A 1 128 SER 128 128 128 SER SER A . n 
A 1 129 ARG 129 129 129 ARG ARG A . n 
A 1 130 PHE 130 130 130 PHE PHE A . n 
A 1 131 ASP 131 131 131 ASP ASP A . n 
A 1 132 MET 132 132 132 MET MET A . n 
A 1 133 GLU 133 133 133 GLU GLU A . n 
A 1 134 LEU 134 134 134 LEU LEU A . n 
A 1 135 THR 135 135 135 THR THR A . n 
A 1 136 PHE 136 136 136 PHE PHE A . n 
A 1 137 VAL 137 137 137 VAL VAL A . n 
A 1 138 VAL 138 138 138 VAL VAL A . n 
A 1 139 THR 139 139 139 THR THR A . n 
A 1 140 SER 140 140 140 SER SER A . n 
A 1 141 ASN 141 141 141 ASN ASN A . n 
A 1 142 TYR 142 142 142 TYR TYR A . n 
A 1 143 THR 143 143 143 THR THR A . n 
A 1 144 ASP 144 144 144 ASP ASP A . n 
A 1 145 ALA 145 145 145 ALA ALA A . n 
A 1 146 ASN 146 146 146 ASN ASN A . n 
A 1 147 ASN 147 147 147 ASN ASN A . n 
A 1 148 GLY 148 148 148 GLY GLY A . n 
A 1 149 HIS 149 149 149 HIS HIS A . n 
A 1 150 ALA 150 150 150 ALA ALA A . n 
A 1 151 LEU 151 151 151 LEU LEU A . n 
A 1 152 ASN 152 152 152 ASN ASN A . n 
A 1 153 GLN 153 153 153 GLN GLN A . n 
A 1 154 VAL 154 154 154 VAL VAL A . n 
A 1 155 TYR 155 155 155 TYR TYR A . n 
A 1 156 GLN 156 156 156 GLN GLN A . n 
A 1 157 ILE 157 157 157 ILE ILE A . n 
A 1 158 MET 158 158 158 MET MET A . n 
A 1 159 PHE 159 159 159 PHE PHE A . n 
A 1 160 ILE 160 160 160 ILE ILE A . n 
A 1 161 PRO 161 161 161 PRO PRO A . n 
A 1 162 PRO 162 162 162 PRO PRO A . n 
A 1 163 GLY 163 163 163 GLY GLY A . n 
A 1 164 ALA 164 164 164 ALA ALA A . n 
A 1 165 PRO 165 165 165 PRO PRO A . n 
A 1 166 ILE 166 166 166 ILE ILE A . n 
A 1 167 PRO 167 167 167 PRO PRO A . n 
A 1 168 GLY 168 168 168 GLY GLY A . n 
A 1 169 LYS 169 169 169 LYS LYS A . n 
A 1 170 TRP 170 170 170 TRP TRP A . n 
A 1 171 ASN 171 171 171 ASN ASN A . n 
A 1 172 ASP 172 172 172 ASP ASP A . n 
A 1 173 TYR 173 173 173 TYR TYR A . n 
A 1 174 THR 174 174 174 THR THR A . n 
A 1 175 TRP 175 175 175 TRP TRP A . n 
A 1 176 GLN 176 176 176 GLN GLN A . n 
A 1 177 THR 177 177 177 THR THR A . n 
A 1 178 SER 178 178 178 SER SER A . n 
A 1 179 SER 179 179 179 SER SER A . n 
A 1 180 ASN 180 180 180 ASN ASN A . n 
A 1 181 PRO 181 181 181 PRO PRO A . n 
A 1 182 SER 182 182 182 SER SER A . n 
A 1 183 VAL 183 183 183 VAL VAL A . n 
A 1 184 PHE 184 184 184 PHE PHE A . n 
A 1 185 TYR 185 185 185 TYR TYR A . n 
A 1 186 THR 186 186 186 THR THR A . n 
A 1 187 TYR 187 187 187 TYR TYR A . n 
A 1 188 GLY 188 188 188 GLY GLY A . n 
A 1 189 ALA 189 189 189 ALA ALA A . n 
A 1 190 PRO 190 190 190 PRO PRO A . n 
A 1 191 PRO 191 191 191 PRO PRO A . n 
A 1 192 ALA 192 192 192 ALA ALA A . n 
A 1 193 ARG 193 193 193 ARG ARG A . n 
A 1 194 ILE 194 194 194 ILE ILE A . n 
A 1 195 SER 195 195 195 SER SER A . n 
A 1 196 VAL 196 196 196 VAL VAL A . n 
A 1 197 PRO 197 197 197 PRO PRO A . n 
A 1 198 TYR 198 198 198 TYR TYR A . n 
A 1 199 VAL 199 199 199 VAL VAL A . n 
A 1 200 GLY 200 200 200 GLY GLY A . n 
A 1 201 ILE 201 201 201 ILE ILE A . n 
A 1 202 ALA 202 202 202 ALA ALA A . n 
A 1 203 ASN 203 203 203 ASN ASN A . n 
A 1 204 ALA 204 204 204 ALA ALA A . n 
A 1 205 TYR 205 205 205 TYR TYR A . n 
A 1 206 SER 206 206 206 SER SER A . n 
A 1 207 HIS 207 207 207 HIS HIS A . n 
A 1 208 PHE 208 208 208 PHE PHE A . n 
A 1 209 TYR 209 209 209 TYR TYR A . n 
A 1 210 ASP 210 210 210 ASP ASP A . n 
A 1 211 GLY 211 211 211 GLY GLY A . n 
A 1 212 PHE 212 212 212 PHE PHE A . n 
A 1 213 ALA 213 213 213 ALA ALA A . n 
A 1 214 LYS 214 214 214 LYS LYS A . n 
A 1 215 VAL 215 215 215 VAL VAL A . n 
A 1 216 PRO 216 216 216 PRO PRO A . n 
A 1 217 LEU 217 217 217 LEU LEU A . n 
A 1 218 ALA 218 218 218 ALA ALA A . n 
A 1 219 GLY 219 219 219 GLY GLY A . n 
A 1 220 GLN 220 220 220 GLN GLN A . n 
A 1 221 ALA 221 221 221 ALA ALA A . n 
A 1 222 SER 222 222 222 SER SER A . n 
A 1 223 THR 223 223 223 THR THR A . n 
A 1 224 GLU 224 224 224 GLU GLU A . n 
A 1 225 GLY 225 225 225 GLY GLY A . n 
A 1 226 ASP 226 226 226 ASP ASP A . n 
A 1 227 SER 227 227 227 SER SER A . n 
A 1 228 LEU 228 228 228 LEU LEU A . n 
A 1 229 TYR 229 229 229 TYR TYR A . n 
A 1 230 GLY 230 230 230 GLY GLY A . n 
A 1 231 ALA 231 231 231 ALA ALA A . n 
A 1 232 ALA 232 232 232 ALA ALA A . n 
A 1 233 SER 233 233 233 SER SER A . n 
A 1 234 LEU 234 234 234 LEU LEU A . n 
A 1 235 ASN 235 235 235 ASN ASN A . n 
A 1 236 ASP 236 236 236 ASP ASP A . n 
A 1 237 PHE 237 237 237 PHE PHE A . n 
A 1 238 GLY 238 238 238 GLY GLY A . n 
A 1 239 SER 239 239 239 SER SER A . n 
A 1 240 LEU 240 240 240 LEU LEU A . n 
A 1 241 ALA 241 241 241 ALA ALA A . n 
A 1 242 VAL 242 242 242 VAL VAL A . n 
A 1 243 ARG 243 243 243 ARG ARG A . n 
A 1 244 VAL 244 244 244 VAL VAL A . n 
A 1 245 VAL 245 245 245 VAL VAL A . n 
A 1 246 ASN 246 246 246 ASN ASN A . n 
A 1 247 ASP 247 247 247 ASP ASP A . n 
A 1 248 HIS 248 248 248 HIS HIS A . n 
A 1 249 ASN 249 249 249 ASN ASN A . n 
A 1 250 PRO 250 250 250 PRO PRO A . n 
A 1 251 THR 251 251 251 THR THR A . n 
A 1 252 LYS 252 252 252 LYS LYS A . n 
A 1 253 LEU 253 253 253 LEU LEU A . n 
A 1 254 THR 254 254 254 THR THR A . n 
A 1 255 SER 255 255 255 SER SER A . n 
A 1 256 LYS 256 256 256 LYS LYS A . n 
A 1 257 ILE 257 257 257 ILE ILE A . n 
A 1 258 ARG 258 258 258 ARG ARG A . n 
A 1 259 VAL 259 259 259 VAL VAL A . n 
A 1 260 TYR 260 260 260 TYR TYR A . n 
A 1 261 MET 261 261 261 MET MET A . n 
A 1 262 LYS 262 262 262 LYS LYS A . n 
A 1 263 PRO 263 263 263 PRO PRO A . n 
A 1 264 LYS 264 264 264 LYS LYS A . n 
A 1 265 HIS 265 265 265 HIS HIS A . n 
A 1 266 VAL 266 266 266 VAL VAL A . n 
A 1 267 ARG 267 267 267 ARG ARG A . n 
A 1 268 VAL 268 268 268 VAL VAL A . n 
A 1 269 TRP 269 269 269 TRP TRP A . n 
A 1 270 CYS 270 270 270 CYS CYS A . n 
A 1 271 PRO 271 271 271 PRO PRO A . n 
A 1 272 ARG 272 272 272 ARG ARG A . n 
A 1 273 PRO 273 273 273 PRO PRO A . n 
A 1 274 PRO 274 274 274 PRO PRO A . n 
A 1 275 ARG 275 275 275 ARG ARG A . n 
A 1 276 ALA 276 276 276 ALA ALA A . n 
A 1 277 VAL 277 277 277 VAL VAL A . n 
A 1 278 PRO 278 278 278 PRO PRO A . n 
A 1 279 TYR 279 279 279 TYR TYR A . n 
A 1 280 TYR 280 280 280 TYR TYR A . n 
A 1 281 GLY 281 281 281 GLY GLY A . n 
A 1 282 PRO 282 282 282 PRO PRO A . n 
A 1 283 GLY 283 283 283 GLY GLY A . n 
A 1 284 VAL 284 284 284 VAL VAL A . n 
A 1 285 ASP 285 285 285 ASP ASP A . n 
A 1 286 TYR 286 286 286 TYR TYR A . n 
A 1 287 LYS 287 287 287 LYS LYS A . n 
A 1 288 ASP 288 288 288 ASP ASP A . n 
A 1 289 GLY 289 289 289 GLY GLY A . n 
A 1 290 LEU 290 290 290 LEU LEU A . n 
A 1 291 ALA 291 291 291 ALA ALA A . n 
A 1 292 PRO 292 292 292 PRO PRO A . n 
A 1 293 LEU 293 293 293 LEU LEU A . n 
A 1 294 PRO 294 294 294 PRO PRO A . n 
A 1 295 GLU 295 295 295 GLU GLU A . n 
A 1 296 LYS 296 296 296 LYS LYS A . n 
A 1 297 GLY 297 297 297 GLY GLY A . n 
A 1 298 LEU 298 298 298 LEU LEU A . n 
A 1 299 THR 299 299 299 THR THR A . n 
A 1 300 THR 300 300 300 THR THR A . n 
A 1 301 TYR 301 301 301 TYR TYR A . n 
B 2 1   MET 1   1   ?   ?   ?   B . n 
B 2 2   GLY 2   2   ?   ?   ?   B . n 
B 2 3   ALA 3   3   ?   ?   ?   B . n 
B 2 4   GLN 4   4   ?   ?   ?   B . n 
B 2 5   VAL 5   5   ?   ?   ?   B . n 
B 2 6   SER 6   6   ?   ?   ?   B . n 
B 2 7   SER 7   7   ?   ?   ?   B . n 
B 2 8   GLN 8   8   ?   ?   ?   B . n 
B 2 9   LYS 9   9   ?   ?   ?   B . n 
B 2 10  VAL 10  10  ?   ?   ?   B . n 
B 2 11  GLY 11  11  ?   ?   ?   B . n 
B 2 12  ALA 12  12  ?   ?   ?   B . n 
B 2 13  HIS 13  13  ?   ?   ?   B . n 
B 2 14  GLU 14  14  ?   ?   ?   B . n 
B 2 15  ASN 15  15  ?   ?   ?   B . n 
B 2 16  SER 16  16  ?   ?   ?   B . n 
B 2 17  ASN 17  17  ?   ?   ?   B . n 
B 2 18  ARG 18  18  ?   ?   ?   B . n 
B 2 19  ALA 19  19  ?   ?   ?   B . n 
B 2 20  TYR 20  20  ?   ?   ?   B . n 
B 2 21  GLY 21  21  ?   ?   ?   B . n 
B 2 22  GLY 22  22  ?   ?   ?   B . n 
B 2 23  SER 23  23  ?   ?   ?   B . n 
B 2 24  THR 24  24  ?   ?   ?   B . n 
B 2 25  ILE 25  25  ?   ?   ?   B . n 
B 2 26  ASN 26  26  ?   ?   ?   B . n 
B 2 27  TYR 27  27  ?   ?   ?   B . n 
B 2 28  THR 28  28  ?   ?   ?   B . n 
B 2 29  THR 29  29  ?   ?   ?   B . n 
B 2 30  ILE 30  30  ?   ?   ?   B . n 
B 2 31  ASN 31  31  ?   ?   ?   B . n 
B 2 32  TYR 32  32  ?   ?   ?   B . n 
B 2 33  TYR 33  33  ?   ?   ?   B . n 
B 2 34  ARG 34  34  ?   ?   ?   B . n 
B 2 35  ASP 35  35  ?   ?   ?   B . n 
B 2 36  SER 36  36  ?   ?   ?   B . n 
B 2 37  ALA 37  37  ?   ?   ?   B . n 
B 2 38  SER 38  38  ?   ?   ?   B . n 
B 2 39  ASN 39  39  ?   ?   ?   B . n 
B 2 40  ALA 40  40  ?   ?   ?   B . n 
B 2 41  ALA 41  41  ?   ?   ?   B . n 
B 2 42  SER 42  42  ?   ?   ?   B . n 
B 2 43  LYS 43  43  ?   ?   ?   B . n 
B 2 44  GLN 44  44  ?   ?   ?   B . n 
B 2 45  ASP 45  45  ?   ?   ?   B . n 
B 2 46  PHE 46  46  ?   ?   ?   B . n 
B 2 47  ALA 47  47  ?   ?   ?   B . n 
B 2 48  GLN 48  48  ?   ?   ?   B . n 
B 2 49  ASP 49  49  ?   ?   ?   B . n 
B 2 50  PRO 50  50  ?   ?   ?   B . n 
B 2 51  SER 51  51  ?   ?   ?   B . n 
B 2 52  LYS 52  52  ?   ?   ?   B . n 
B 2 53  PHE 53  53  ?   ?   ?   B . n 
B 2 54  THR 54  54  ?   ?   ?   B . n 
B 2 55  GLU 55  55  ?   ?   ?   B . n 
B 2 56  PRO 56  56  ?   ?   ?   B . n 
B 2 57  ILE 57  57  ?   ?   ?   B . n 
B 2 58  LYS 58  58  ?   ?   ?   B . n 
B 2 59  ASP 59  59  ?   ?   ?   B . n 
B 2 60  VAL 60  60  ?   ?   ?   B . n 
B 2 61  LEU 61  61  ?   ?   ?   B . n 
B 2 62  ILE 62  62  ?   ?   ?   B . n 
B 2 63  LYS 63  63  ?   ?   ?   B . n 
B 2 64  THR 64  64  ?   ?   ?   B . n 
B 2 65  ALA 65  65  ?   ?   ?   B . n 
B 2 66  PRO 66  66  ?   ?   ?   B . n 
B 2 67  THR 67  67  ?   ?   ?   B . n 
B 2 68  LEU 68  68  ?   ?   ?   B . n 
B 2 69  ASN 69  69  ?   ?   ?   B . n 
B 2 70  SER 70  70  ?   ?   ?   B . n 
B 2 71  PRO 71  71  ?   ?   ?   B . n 
B 2 72  ASN 72  72  ?   ?   ?   B . n 
B 2 73  ILE 73  73  ?   ?   ?   B . n 
B 2 74  GLU 74  74  ?   ?   ?   B . n 
B 2 75  ALA 75  75  ?   ?   ?   B . n 
B 2 76  CYS 76  76  ?   ?   ?   B . n 
B 2 77  GLY 77  77  ?   ?   ?   B . n 
B 2 78  TYR 78  78  ?   ?   ?   B . n 
B 2 79  SER 79  79  ?   ?   ?   B . n 
B 2 80  ASP 80  80  ?   ?   ?   B . n 
B 2 81  ARG 81  81  ?   ?   ?   B . n 
B 2 82  VAL 82  82  ?   ?   ?   B . n 
B 2 83  MET 83  83  ?   ?   ?   B . n 
B 2 84  GLN 84  84  84  GLN GLN B . n 
B 2 85  LEU 85  85  85  LEU LEU B . n 
B 2 86  THR 86  86  86  THR THR B . n 
B 2 87  LEU 87  87  87  LEU LEU B . n 
B 2 88  GLY 88  88  88  GLY GLY B . n 
B 2 89  ASN 89  89  89  ASN ASN B . n 
B 2 90  SER 90  90  90  SER SER B . n 
B 2 91  THR 91  91  91  THR THR B . n 
B 2 92  ILE 92  92  92  ILE ILE B . n 
B 2 93  THR 93  93  93  THR THR B . n 
B 2 94  THR 94  94  ?   ?   ?   B . n 
B 2 95  GLN 95  95  ?   ?   ?   B . n 
B 2 96  GLU 96  96  ?   ?   ?   B . n 
B 2 97  ALA 97  97  ?   ?   ?   B . n 
B 2 98  ALA 98  98  ?   ?   ?   B . n 
B 2 99  ASN 99  99  99  ASN ASN B . n 
B 2 100 SER 100 100 100 SER SER B . n 
B 2 101 VAL 101 101 101 VAL VAL B . n 
B 2 102 VAL 102 102 102 VAL VAL B . n 
B 2 103 ALA 103 103 103 ALA ALA B . n 
B 2 104 TYR 104 104 104 TYR TYR B . n 
B 2 105 GLY 105 105 105 GLY GLY B . n 
B 2 106 ARG 106 106 106 ARG ARG B . n 
B 2 107 TRP 107 107 107 TRP TRP B . n 
B 2 108 PRO 108 108 108 PRO PRO B . n 
B 2 109 GLU 109 109 109 GLU GLU B . n 
B 2 110 TYR 110 110 110 TYR TYR B . n 
B 2 111 ILE 111 111 111 ILE ILE B . n 
B 2 112 LYS 112 112 112 LYS LYS B . n 
B 2 113 ASP 113 113 113 ASP ASP B . n 
B 2 114 SER 114 114 114 SER SER B . n 
B 2 115 GLU 115 115 115 GLU GLU B . n 
B 2 116 ALA 116 116 116 ALA ALA B . n 
B 2 117 ASN 117 117 117 ASN ASN B . n 
B 2 118 PRO 118 118 118 PRO PRO B . n 
B 2 119 VAL 119 119 119 VAL VAL B . n 
B 2 120 ASP 120 120 120 ASP ASP B . n 
B 2 121 GLN 121 121 121 GLN GLN B . n 
B 2 122 PRO 122 122 122 PRO PRO B . n 
B 2 123 THR 123 123 123 THR THR B . n 
B 2 124 GLU 124 124 124 GLU GLU B . n 
B 2 125 PRO 125 125 125 PRO PRO B . n 
B 2 126 ASP 126 126 126 ASP ASP B . n 
B 2 127 VAL 127 127 127 VAL VAL B . n 
B 2 128 ALA 128 128 128 ALA ALA B . n 
B 2 129 ALA 129 129 129 ALA ALA B . n 
B 2 130 CYS 130 130 130 CYS CYS B . n 
B 2 131 ARG 131 131 131 ARG ARG B . n 
B 2 132 PHE 132 132 132 PHE PHE B . n 
B 2 133 TYR 133 133 133 TYR TYR B . n 
B 2 134 THR 134 134 134 THR THR B . n 
B 2 135 LEU 135 135 135 LEU LEU B . n 
B 2 136 ASP 136 136 136 ASP ASP B . n 
B 2 137 THR 137 137 137 THR THR B . n 
B 2 138 VAL 138 138 138 VAL VAL B . n 
B 2 139 THR 139 139 139 THR THR B . n 
B 2 140 TRP 140 140 140 TRP TRP B . n 
B 2 141 ARG 141 141 141 ARG ARG B . n 
B 2 142 LYS 142 142 142 LYS LYS B . n 
B 2 143 GLU 143 143 143 GLU GLU B . n 
B 2 144 SER 144 144 144 SER SER B . n 
B 2 145 ARG 145 145 145 ARG ARG B . n 
B 2 146 GLY 146 146 146 GLY GLY B . n 
B 2 147 TRP 147 147 147 TRP TRP B . n 
B 2 148 TRP 148 148 148 TRP TRP B . n 
B 2 149 TRP 149 149 149 TRP TRP B . n 
B 2 150 LYS 150 150 150 LYS LYS B . n 
B 2 151 LEU 151 151 151 LEU LEU B . n 
B 2 152 PRO 152 152 152 PRO PRO B . n 
B 2 153 ASP 153 153 153 ASP ASP B . n 
B 2 154 ALA 154 154 154 ALA ALA B . n 
B 2 155 LEU 155 155 155 LEU LEU B . n 
B 2 156 LYS 156 156 156 LYS LYS B . n 
B 2 157 ASP 157 157 157 ASP ASP B . n 
B 2 158 MET 158 158 158 MET MET B . n 
B 2 159 GLY 159 159 159 GLY GLY B . n 
B 2 160 LEU 160 160 160 LEU LEU B . n 
B 2 161 PHE 161 161 161 PHE PHE B . n 
B 2 162 GLY 162 162 162 GLY GLY B . n 
B 2 163 GLN 163 163 163 GLN GLN B . n 
B 2 164 ASN 164 164 164 ASN ASN B . n 
B 2 165 MET 165 165 165 MET MET B . n 
B 2 166 PHE 166 166 166 PHE PHE B . n 
B 2 167 TYR 167 167 167 TYR TYR B . n 
B 2 168 HIS 168 168 168 HIS HIS B . n 
B 2 169 TYR 169 169 169 TYR TYR B . n 
B 2 170 LEU 170 170 170 LEU LEU B . n 
B 2 171 GLY 171 171 171 GLY GLY B . n 
B 2 172 ARG 172 172 172 ARG ARG B . n 
B 2 173 ALA 173 173 173 ALA ALA B . n 
B 2 174 GLY 174 174 174 GLY GLY B . n 
B 2 175 TYR 175 175 175 TYR TYR B . n 
B 2 176 THR 176 176 176 THR THR B . n 
B 2 177 VAL 177 177 177 VAL VAL B . n 
B 2 178 HIS 178 178 178 HIS HIS B . n 
B 2 179 VAL 179 179 179 VAL VAL B . n 
B 2 180 GLN 180 180 180 GLN GLN B . n 
B 2 181 CYS 181 181 181 CYS CYS B . n 
B 2 182 ASN 182 182 182 ASN ASN B . n 
B 2 183 ALA 183 183 183 ALA ALA B . n 
B 2 184 SER 184 184 184 SER SER B . n 
B 2 185 LYS 185 185 185 LYS LYS B . n 
B 2 186 PHE 186 186 186 PHE PHE B . n 
B 2 187 HIS 187 187 187 HIS HIS B . n 
B 2 188 GLN 188 188 188 GLN GLN B . n 
B 2 189 GLY 189 189 189 GLY GLY B . n 
B 2 190 ALA 190 190 190 ALA ALA B . n 
B 2 191 LEU 191 191 191 LEU LEU B . n 
B 2 192 GLY 192 192 192 GLY GLY B . n 
B 2 193 VAL 193 193 193 VAL VAL B . n 
B 2 194 PHE 194 194 194 PHE PHE B . n 
B 2 195 ALA 195 195 195 ALA ALA B . n 
B 2 196 VAL 196 196 196 VAL VAL B . n 
B 2 197 PRO 197 197 197 PRO PRO B . n 
B 2 198 GLU 198 198 198 GLU GLU B . n 
B 2 199 MET 199 199 199 MET MET B . n 
B 2 200 CYS 200 200 200 CYS CYS B . n 
B 2 201 LEU 201 201 201 LEU LEU B . n 
B 2 202 ALA 202 202 202 ALA ALA B . n 
B 2 203 GLY 203 203 203 GLY GLY B . n 
B 2 204 ASP 204 204 204 ASP ASP B . n 
B 2 205 SER 205 205 205 SER SER B . n 
B 2 206 THR 206 206 206 THR THR B . n 
B 2 207 THR 207 207 207 THR THR B . n 
B 2 208 HIS 208 208 208 HIS HIS B . n 
B 2 209 MET 209 209 209 MET MET B . n 
B 2 210 PHE 210 210 210 PHE PHE B . n 
B 2 211 THR 211 211 211 THR THR B . n 
B 2 212 LYS 212 212 212 LYS LYS B . n 
B 2 213 TYR 213 213 213 TYR TYR B . n 
B 2 214 GLU 214 214 214 GLU GLU B . n 
B 2 215 ASN 215 215 215 ASN ASN B . n 
B 2 216 ALA 216 216 216 ALA ALA B . n 
B 2 217 ASN 217 217 217 ASN ASN B . n 
B 2 218 PRO 218 218 218 PRO PRO B . n 
B 2 219 GLY 219 219 219 GLY GLY B . n 
B 2 220 GLU 220 220 220 GLU GLU B . n 
B 2 221 LYS 221 221 221 LYS LYS B . n 
B 2 222 GLY 222 222 222 GLY GLY B . n 
B 2 223 GLY 223 223 223 GLY GLY B . n 
B 2 224 GLU 224 224 224 GLU GLU B . n 
B 2 225 PHE 225 225 225 PHE PHE B . n 
B 2 226 LYS 226 226 226 LYS LYS B . n 
B 2 227 GLY 227 227 227 GLY GLY B . n 
B 2 228 SER 228 228 228 SER SER B . n 
B 2 229 PHE 229 229 229 PHE PHE B . n 
B 2 230 THR 230 230 230 THR THR B . n 
B 2 231 LEU 231 231 231 LEU LEU B . n 
B 2 232 ASP 232 232 232 ASP ASP B . n 
B 2 233 THR 233 233 233 THR THR B . n 
B 2 234 ASN 234 234 234 ASN ASN B . n 
B 2 235 ALA 235 235 235 ALA ALA B . n 
B 2 236 THR 236 236 236 THR THR B . n 
B 2 237 ASN 237 237 237 ASN ASN B . n 
B 2 238 PRO 238 238 238 PRO PRO B . n 
B 2 239 ALA 239 239 239 ALA ALA B . n 
B 2 240 ARG 240 240 240 ARG ARG B . n 
B 2 241 ASN 241 241 241 ASN ASN B . n 
B 2 242 PHE 242 242 242 PHE PHE B . n 
B 2 243 CYS 243 243 243 CYS CYS B . n 
B 2 244 PRO 244 244 244 PRO PRO B . n 
B 2 245 VAL 245 245 245 VAL VAL B . n 
B 2 246 ASP 246 246 246 ASP ASP B . n 
B 2 247 TYR 247 247 247 TYR TYR B . n 
B 2 248 LEU 248 248 248 LEU LEU B . n 
B 2 249 PHE 249 249 249 PHE PHE B . n 
B 2 250 GLY 250 250 250 GLY GLY B . n 
B 2 251 SER 251 251 251 SER SER B . n 
B 2 252 GLY 252 252 252 GLY GLY B . n 
B 2 253 VAL 253 253 253 VAL VAL B . n 
B 2 254 LEU 254 254 254 LEU LEU B . n 
B 2 255 ALA 255 255 255 ALA ALA B . n 
B 2 256 GLY 256 256 256 GLY GLY B . n 
B 2 257 ASN 257 257 257 ASN ASN B . n 
B 2 258 ALA 258 258 258 ALA ALA B . n 
B 2 259 PHE 259 259 259 PHE PHE B . n 
B 2 260 VAL 260 260 260 VAL VAL B . n 
B 2 261 TYR 261 261 261 TYR TYR B . n 
B 2 262 PRO 262 262 262 PRO PRO B . n 
B 2 263 HIS 263 263 263 HIS HIS B . n 
B 2 264 GLN 264 264 264 GLN GLN B . n 
B 2 265 ILE 265 265 265 ILE ILE B . n 
B 2 266 ILE 266 266 266 ILE ILE B . n 
B 2 267 ASN 267 267 267 ASN ASN B . n 
B 2 268 LEU 268 268 268 LEU LEU B . n 
B 2 269 ARG 269 269 269 ARG ARG B . n 
B 2 270 THR 270 270 270 THR THR B . n 
B 2 271 ASN 271 271 271 ASN ASN B . n 
B 2 272 ASN 272 272 272 ASN ASN B . n 
B 2 273 CYS 273 273 273 CYS CYS B . n 
B 2 274 ALA 274 274 274 ALA ALA B . n 
B 2 275 THR 275 275 275 THR THR B . n 
B 2 276 LEU 276 276 276 LEU LEU B . n 
B 2 277 VAL 277 277 277 VAL VAL B . n 
B 2 278 LEU 278 278 278 LEU LEU B . n 
B 2 279 PRO 279 279 279 PRO PRO B . n 
B 2 280 TYR 280 280 280 TYR TYR B . n 
B 2 281 VAL 281 281 281 VAL VAL B . n 
B 2 282 ASN 282 282 282 ASN ASN B . n 
B 2 283 SER 283 283 283 SER SER B . n 
B 2 284 LEU 284 284 284 LEU LEU B . n 
B 2 285 SER 285 285 285 SER SER B . n 
B 2 286 ILE 286 286 286 ILE ILE B . n 
B 2 287 ASP 287 287 287 ASP ASP B . n 
B 2 288 SER 288 288 288 SER SER B . n 
B 2 289 MET 289 289 289 MET MET B . n 
B 2 290 THR 290 290 290 THR THR B . n 
B 2 291 LYS 291 291 291 LYS LYS B . n 
B 2 292 HIS 292 292 292 HIS HIS B . n 
B 2 293 ASN 293 293 293 ASN ASN B . n 
B 2 294 ASN 294 294 294 ASN ASN B . n 
B 2 295 TRP 295 295 295 TRP TRP B . n 
B 2 296 GLY 296 296 296 GLY GLY B . n 
B 2 297 ILE 297 297 297 ILE ILE B . n 
B 2 298 ALA 298 298 298 ALA ALA B . n 
B 2 299 ILE 299 299 299 ILE ILE B . n 
B 2 300 LEU 300 300 300 LEU LEU B . n 
B 2 301 PRO 301 301 301 PRO PRO B . n 
B 2 302 LEU 302 302 302 LEU LEU B . n 
B 2 303 ALA 303 303 303 ALA ALA B . n 
B 2 304 PRO 304 304 304 PRO PRO B . n 
B 2 305 LEU 305 305 305 LEU LEU B . n 
B 2 306 ASP 306 306 306 ASP ASP B . n 
B 2 307 PHE 307 307 307 PHE PHE B . n 
B 2 308 ALA 308 308 308 ALA ALA B . n 
B 2 309 THR 309 309 309 THR THR B . n 
B 2 310 GLU 310 310 ?   ?   ?   B . n 
B 2 311 SER 311 311 ?   ?   ?   B . n 
B 2 312 SER 312 312 ?   ?   ?   B . n 
B 2 313 THR 313 313 313 THR THR B . n 
B 2 314 GLU 314 314 314 GLU GLU B . n 
B 2 315 ILE 315 315 315 ILE ILE B . n 
B 2 316 PRO 316 316 316 PRO PRO B . n 
B 2 317 ILE 317 317 317 ILE ILE B . n 
B 2 318 THR 318 318 318 THR THR B . n 
B 2 319 LEU 319 319 319 LEU LEU B . n 
B 2 320 THR 320 320 320 THR THR B . n 
B 2 321 ILE 321 321 321 ILE ILE B . n 
B 2 322 ALA 322 322 322 ALA ALA B . n 
B 2 323 PRO 323 323 323 PRO PRO B . n 
B 2 324 MET 324 324 324 MET MET B . n 
B 2 325 CYS 325 325 325 CYS CYS B . n 
B 2 326 CYS 326 326 326 CYS CYS B . n 
B 2 327 GLU 327 327 327 GLU GLU B . n 
B 2 328 PHE 328 328 328 PHE PHE B . n 
B 2 329 ASN 329 329 329 ASN ASN B . n 
B 2 330 GLY 330 330 330 GLY GLY B . n 
B 2 331 LEU 331 331 331 LEU LEU B . n 
B 2 332 ARG 332 332 332 ARG ARG B . n 
B 2 333 ASN 333 333 333 ASN ASN B . n 
B 2 334 ILE 334 334 334 ILE ILE B . n 
B 2 335 THR 335 335 335 THR THR B . n 
B 2 336 VAL 336 336 336 VAL VAL B . n 
B 2 337 PRO 337 337 337 PRO PRO B . n 
B 2 338 ARG 338 338 338 ARG ARG B . n 
B 2 339 THR 339 339 339 THR THR B . n 
B 2 340 GLN 340 340 340 GLN GLN B . n 
C 3 1   GLY 1   1   1   GLY GLY C . n 
C 3 2   LEU 2   2   2   LEU LEU C . n 
C 3 3   PRO 3   3   3   PRO PRO C . n 
C 3 4   VAL 4   4   4   VAL VAL C . n 
C 3 5   LEU 5   5   5   LEU LEU C . n 
C 3 6   ASN 6   6   6   ASN ASN C . n 
C 3 7   THR 7   7   7   THR THR C . n 
C 3 8   PRO 8   8   8   PRO PRO C . n 
C 3 9   GLY 9   9   9   GLY GLY C . n 
C 3 10  SER 10  10  10  SER SER C . n 
C 3 11  ASN 11  11  11  ASN ASN C . n 
C 3 12  GLN 12  12  12  GLN GLN C . n 
C 3 13  TYR 13  13  13  TYR TYR C . n 
C 3 14  LEU 14  14  14  LEU LEU C . n 
C 3 15  THR 15  15  15  THR THR C . n 
C 3 16  ALA 16  16  16  ALA ALA C . n 
C 3 17  ASP 17  17  17  ASP ASP C . n 
C 3 18  ASN 18  18  18  ASN ASN C . n 
C 3 19  TYR 19  19  19  TYR TYR C . n 
C 3 20  GLN 20  20  20  GLN GLN C . n 
C 3 21  SER 21  21  21  SER SER C . n 
C 3 22  PRO 22  22  22  PRO PRO C . n 
C 3 23  CYS 23  23  23  CYS CYS C . n 
C 3 24  ALA 24  24  24  ALA ALA C . n 
C 3 25  ILE 25  25  25  ILE ILE C . n 
C 3 26  PRO 26  26  26  PRO PRO C . n 
C 3 27  GLU 27  27  27  GLU GLU C . n 
C 3 28  PHE 28  28  28  PHE PHE C . n 
C 3 29  ASP 29  29  29  ASP ASP C . n 
C 3 30  VAL 30  30  30  VAL VAL C . n 
C 3 31  THR 31  31  31  THR THR C . n 
C 3 32  PRO 32  32  32  PRO PRO C . n 
C 3 33  PRO 33  33  33  PRO PRO C . n 
C 3 34  ILE 34  34  34  ILE ILE C . n 
C 3 35  ASP 35  35  35  ASP ASP C . n 
C 3 36  ILE 36  36  36  ILE ILE C . n 
C 3 37  PRO 37  37  37  PRO PRO C . n 
C 3 38  GLY 38  38  38  GLY GLY C . n 
C 3 39  GLU 39  39  39  GLU GLU C . n 
C 3 40  VAL 40  40  40  VAL VAL C . n 
C 3 41  ARG 41  41  41  ARG ARG C . n 
C 3 42  ASN 42  42  42  ASN ASN C . n 
C 3 43  MET 43  43  43  MET MET C . n 
C 3 44  MET 44  44  44  MET MET C . n 
C 3 45  GLU 45  45  45  GLU GLU C . n 
C 3 46  LEU 46  46  46  LEU LEU C . n 
C 3 47  ALA 47  47  47  ALA ALA C . n 
C 3 48  GLU 48  48  48  GLU GLU C . n 
C 3 49  ILE 49  49  49  ILE ILE C . n 
C 3 50  ASP 50  50  50  ASP ASP C . n 
C 3 51  THR 51  51  51  THR THR C . n 
C 3 52  MET 52  52  52  MET MET C . n 
C 3 53  ILE 53  53  53  ILE ILE C . n 
C 3 54  PRO 54  54  54  PRO PRO C . n 
C 3 55  LEU 55  55  55  LEU LEU C . n 
C 3 56  ASN 56  56  56  ASN ASN C . n 
C 3 57  LEU 57  57  57  LEU LEU C . n 
C 3 58  THR 58  58  58  THR THR C . n 
C 3 59  ASN 59  59  59  ASN ASN C . n 
C 3 60  GLN 60  60  60  GLN GLN C . n 
C 3 61  ARG 61  61  61  ARG ARG C . n 
C 3 62  LYS 62  62  62  LYS LYS C . n 
C 3 63  ASN 63  63  63  ASN ASN C . n 
C 3 64  THR 64  64  64  THR THR C . n 
C 3 65  MET 65  65  65  MET MET C . n 
C 3 66  ASP 66  66  66  ASP ASP C . n 
C 3 67  MET 67  67  67  MET MET C . n 
C 3 68  TYR 68  68  68  TYR TYR C . n 
C 3 69  ARG 69  69  69  ARG ARG C . n 
C 3 70  VAL 70  70  70  VAL VAL C . n 
C 3 71  GLU 71  71  71  GLU GLU C . n 
C 3 72  LEU 72  72  72  LEU LEU C . n 
C 3 73  ASN 73  73  73  ASN ASN C . n 
C 3 74  ASP 74  74  74  ASP ASP C . n 
C 3 75  ALA 75  75  75  ALA ALA C . n 
C 3 76  ALA 76  76  76  ALA ALA C . n 
C 3 77  HIS 77  77  77  HIS HIS C . n 
C 3 78  SER 78  78  78  SER SER C . n 
C 3 79  ASP 79  79  79  ASP ASP C . n 
C 3 80  THR 80  80  80  THR THR C . n 
C 3 81  PRO 81  81  81  PRO PRO C . n 
C 3 82  ILE 82  82  82  ILE ILE C . n 
C 3 83  LEU 83  83  83  LEU LEU C . n 
C 3 84  CYS 84  84  84  CYS CYS C . n 
C 3 85  PHE 85  85  85  PHE PHE C . n 
C 3 86  SER 86  86  86  SER SER C . n 
C 3 87  LEU 87  87  87  LEU LEU C . n 
C 3 88  SER 88  88  88  SER SER C . n 
C 3 89  PRO 89  89  89  PRO PRO C . n 
C 3 90  ALA 90  90  90  ALA ALA C . n 
C 3 91  SER 91  91  91  SER SER C . n 
C 3 92  ASP 92  92  92  ASP ASP C . n 
C 3 93  PRO 93  93  93  PRO PRO C . n 
C 3 94  ARG 94  94  94  ARG ARG C . n 
C 3 95  LEU 95  95  95  LEU LEU C . n 
C 3 96  ALA 96  96  96  ALA ALA C . n 
C 3 97  HIS 97  97  97  HIS HIS C . n 
C 3 98  THR 98  98  98  THR THR C . n 
C 3 99  MET 99  99  99  MET MET C . n 
C 3 100 LEU 100 100 100 LEU LEU C . n 
C 3 101 GLY 101 101 101 GLY GLY C . n 
C 3 102 GLU 102 102 102 GLU GLU C . n 
C 3 103 ILE 103 103 103 ILE ILE C . n 
C 3 104 LEU 104 104 104 LEU LEU C . n 
C 3 105 ASN 105 105 105 ASN ASN C . n 
C 3 106 TYR 106 106 106 TYR TYR C . n 
C 3 107 TYR 107 107 107 TYR TYR C . n 
C 3 108 THR 108 108 108 THR THR C . n 
C 3 109 HIS 109 109 109 HIS HIS C . n 
C 3 110 TRP 110 110 110 TRP TRP C . n 
C 3 111 ALA 111 111 111 ALA ALA C . n 
C 3 112 GLY 112 112 112 GLY GLY C . n 
C 3 113 SER 113 113 113 SER SER C . n 
C 3 114 LEU 114 114 114 LEU LEU C . n 
C 3 115 LYS 115 115 115 LYS LYS C . n 
C 3 116 PHE 116 116 116 PHE PHE C . n 
C 3 117 THR 117 117 117 THR THR C . n 
C 3 118 PHE 118 118 118 PHE PHE C . n 
C 3 119 LEU 119 119 119 LEU LEU C . n 
C 3 120 PHE 120 120 120 PHE PHE C . n 
C 3 121 CYS 121 121 121 CYS CYS C . n 
C 3 122 GLY 122 122 122 GLY GLY C . n 
C 3 123 SER 123 123 123 SER SER C . n 
C 3 124 MET 124 124 124 MET MET C . n 
C 3 125 MET 125 125 125 MET MET C . n 
C 3 126 ALA 126 126 126 ALA ALA C . n 
C 3 127 THR 127 127 127 THR THR C . n 
C 3 128 GLY 128 128 128 GLY GLY C . n 
C 3 129 LYS 129 129 129 LYS LYS C . n 
C 3 130 LEU 130 130 130 LEU LEU C . n 
C 3 131 LEU 131 131 131 LEU LEU C . n 
C 3 132 VAL 132 132 132 VAL VAL C . n 
C 3 133 SER 133 133 133 SER SER C . n 
C 3 134 TYR 134 134 134 TYR TYR C . n 
C 3 135 ALA 135 135 135 ALA ALA C . n 
C 3 136 PRO 136 136 136 PRO PRO C . n 
C 3 137 PRO 137 137 137 PRO PRO C . n 
C 3 138 GLY 138 138 138 GLY GLY C . n 
C 3 139 ALA 139 139 139 ALA ALA C . n 
C 3 140 GLU 140 140 140 GLU GLU C . n 
C 3 141 ALA 141 141 141 ALA ALA C . n 
C 3 142 PRO 142 142 142 PRO PRO C . n 
C 3 143 LYS 143 143 143 LYS LYS C . n 
C 3 144 SER 144 144 144 SER SER C . n 
C 3 145 ARG 145 145 145 ARG ARG C . n 
C 3 146 LYS 146 146 146 LYS LYS C . n 
C 3 147 GLU 147 147 147 GLU GLU C . n 
C 3 148 ALA 148 148 148 ALA ALA C . n 
C 3 149 MET 149 149 149 MET MET C . n 
C 3 150 LEU 150 150 150 LEU LEU C . n 
C 3 151 GLY 151 151 151 GLY GLY C . n 
C 3 152 THR 152 152 152 THR THR C . n 
C 3 153 HIS 153 153 153 HIS HIS C . n 
C 3 154 VAL 154 154 154 VAL VAL C . n 
C 3 155 ILE 155 155 155 ILE ILE C . n 
C 3 156 TRP 156 156 156 TRP TRP C . n 
C 3 157 ASP 157 157 157 ASP ASP C . n 
C 3 158 ILE 158 158 158 ILE ILE C . n 
C 3 159 GLY 159 159 159 GLY GLY C . n 
C 3 160 LEU 160 160 160 LEU LEU C . n 
C 3 161 GLN 161 161 161 GLN GLN C . n 
C 3 162 SER 162 162 162 SER SER C . n 
C 3 163 SER 163 163 163 SER SER C . n 
C 3 164 CYS 164 164 164 CYS CYS C . n 
C 3 165 THR 165 165 165 THR THR C . n 
C 3 166 MET 166 166 166 MET MET C . n 
C 3 167 VAL 167 167 167 VAL VAL C . n 
C 3 168 VAL 168 168 168 VAL VAL C . n 
C 3 169 PRO 169 169 169 PRO PRO C . n 
C 3 170 TRP 170 170 170 TRP TRP C . n 
C 3 171 ILE 171 171 171 ILE ILE C . n 
C 3 172 SER 172 172 172 SER SER C . n 
C 3 173 ASN 173 173 173 ASN ASN C . n 
C 3 174 THR 174 174 174 THR THR C . n 
C 3 175 THR 175 175 175 THR THR C . n 
C 3 176 TYR 176 176 176 TYR TYR C . n 
C 3 177 ARG 177 177 177 ARG ARG C . n 
C 3 178 LEU 178 178 178 LEU LEU C . n 
C 3 179 THR 179 179 179 THR THR C . n 
C 3 180 ILE 180 180 180 ILE ILE C . n 
C 3 181 ASN 181 181 181 ASN ASN C . n 
C 3 182 ASP 182 182 182 ASP ASP C . n 
C 3 183 SER 183 183 183 SER SER C . n 
C 3 184 PHE 184 184 184 PHE PHE C . n 
C 3 185 THR 185 185 185 THR THR C . n 
C 3 186 GLU 186 186 186 GLU GLU C . n 
C 3 187 GLY 187 187 187 GLY GLY C . n 
C 3 188 GLY 188 188 188 GLY GLY C . n 
C 3 189 TYR 189 189 189 TYR TYR C . n 
C 3 190 ILE 190 190 190 ILE ILE C . n 
C 3 191 SER 191 191 191 SER SER C . n 
C 3 192 MET 192 192 192 MET MET C . n 
C 3 193 PHE 193 193 193 PHE PHE C . n 
C 3 194 TYR 194 194 194 TYR TYR C . n 
C 3 195 GLN 195 195 195 GLN GLN C . n 
C 3 196 THR 196 196 196 THR THR C . n 
C 3 197 ARG 197 197 197 ARG ARG C . n 
C 3 198 VAL 198 198 198 VAL VAL C . n 
C 3 199 VAL 199 199 199 VAL VAL C . n 
C 3 200 VAL 200 200 200 VAL VAL C . n 
C 3 201 PRO 201 201 201 PRO PRO C . n 
C 3 202 LEU 202 202 202 LEU LEU C . n 
C 3 203 SER 203 203 203 SER SER C . n 
C 3 204 THR 204 204 204 THR THR C . n 
C 3 205 PRO 205 205 205 PRO PRO C . n 
C 3 206 ARG 206 206 206 ARG ARG C . n 
C 3 207 LYS 207 207 207 LYS LYS C . n 
C 3 208 MET 208 208 208 MET MET C . n 
C 3 209 ASP 209 209 209 ASP ASP C . n 
C 3 210 ILE 210 210 210 ILE ILE C . n 
C 3 211 LEU 211 211 211 LEU LEU C . n 
C 3 212 GLY 212 212 212 GLY GLY C . n 
C 3 213 PHE 213 213 213 PHE PHE C . n 
C 3 214 VAL 214 214 214 VAL VAL C . n 
C 3 215 SER 215 215 215 SER SER C . n 
C 3 216 ALA 216 216 216 ALA ALA C . n 
C 3 217 CYS 217 217 217 CYS CYS C . n 
C 3 218 ASN 218 218 218 ASN ASN C . n 
C 3 219 ASP 219 219 219 ASP ASP C . n 
C 3 220 PHE 220 220 220 PHE PHE C . n 
C 3 221 SER 221 221 221 SER SER C . n 
C 3 222 VAL 222 222 222 VAL VAL C . n 
C 3 223 ARG 223 223 223 ARG ARG C . n 
C 3 224 LEU 224 224 224 LEU LEU C . n 
C 3 225 LEU 225 225 225 LEU LEU C . n 
C 3 226 ARG 226 226 226 ARG ARG C . n 
C 3 227 ASP 227 227 227 ASP ASP C . n 
C 3 228 THR 228 228 228 THR THR C . n 
C 3 229 THR 229 229 229 THR THR C . n 
C 3 230 HIS 230 230 230 HIS HIS C . n 
C 3 231 ILE 231 231 231 ILE ILE C . n 
C 3 232 SER 232 232 232 SER SER C . n 
C 3 233 GLN 233 233 233 GLN GLN C . n 
C 3 234 GLU 234 234 234 GLU GLU C . n 
C 3 235 ALA 235 235 235 ALA ALA C . n 
C 3 236 MET 236 236 ?   ?   ?   C . n 
C 3 237 PRO 237 237 ?   ?   ?   C . n 
C 3 238 GLN 238 238 ?   ?   ?   C . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        SPH 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   SPH 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
D 4 SPH 1  401 401 SPH SPH A . 
E 5 HOH 1  501 323 HOH HOH A . 
E 5 HOH 2  502 333 HOH HOH A . 
E 5 HOH 3  503 329 HOH HOH A . 
E 5 HOH 4  504 347 HOH HOH A . 
E 5 HOH 5  505 310 HOH HOH A . 
E 5 HOH 6  506 307 HOH HOH A . 
E 5 HOH 7  507 304 HOH HOH A . 
E 5 HOH 8  508 348 HOH HOH A . 
E 5 HOH 9  509 345 HOH HOH A . 
E 5 HOH 10 510 322 HOH HOH A . 
E 5 HOH 11 511 352 HOH HOH A . 
E 5 HOH 12 512 350 HOH HOH A . 
E 5 HOH 13 513 314 HOH HOH A . 
E 5 HOH 14 514 338 HOH HOH A . 
E 5 HOH 15 515 331 HOH HOH A . 
E 5 HOH 16 516 344 HOH HOH A . 
E 5 HOH 17 517 349 HOH HOH A . 
E 5 HOH 18 518 330 HOH HOH A . 
E 5 HOH 19 519 353 HOH HOH A . 
E 5 HOH 20 520 351 HOH HOH A . 
E 5 HOH 21 521 313 HOH HOH A . 
E 5 HOH 22 522 315 HOH HOH A . 
E 5 HOH 23 523 341 HOH HOH A . 
E 5 HOH 24 524 343 HOH HOH A . 
E 5 HOH 25 525 346 HOH HOH A . 
E 5 HOH 26 526 325 HOH HOH A . 
E 5 HOH 27 527 335 HOH HOH A . 
E 5 HOH 28 528 318 HOH HOH A . 
E 5 HOH 29 529 356 HOH HOH A . 
E 5 HOH 30 530 332 HOH HOH A . 
E 5 HOH 31 531 334 HOH HOH A . 
E 5 HOH 32 532 339 HOH HOH A . 
E 5 HOH 33 533 312 HOH HOH A . 
E 5 HOH 34 534 359 HOH HOH A . 
E 5 HOH 35 535 306 HOH HOH A . 
E 5 HOH 36 536 320 HOH HOH A . 
E 5 HOH 37 537 336 HOH HOH A . 
E 5 HOH 38 538 358 HOH HOH A . 
E 5 HOH 39 539 354 HOH HOH A . 
E 5 HOH 40 540 303 HOH HOH A . 
E 5 HOH 41 541 340 HOH HOH A . 
E 5 HOH 42 542 305 HOH HOH A . 
E 5 HOH 43 543 309 HOH HOH A . 
E 5 HOH 44 544 317 HOH HOH A . 
E 5 HOH 45 545 328 HOH HOH A . 
E 5 HOH 46 546 355 HOH HOH A . 
E 5 HOH 47 547 342 HOH HOH A . 
E 5 HOH 48 548 324 HOH HOH A . 
E 5 HOH 49 549 360 HOH HOH A . 
E 5 HOH 50 550 302 HOH HOH A . 
E 5 HOH 51 551 337 HOH HOH A . 
E 5 HOH 52 552 316 HOH HOH A . 
E 5 HOH 53 553 321 HOH HOH A . 
E 5 HOH 54 554 311 HOH HOH A . 
E 5 HOH 55 555 326 HOH HOH A . 
E 5 HOH 56 556 319 HOH HOH A . 
E 5 HOH 57 557 357 HOH HOH A . 
E 5 HOH 58 558 308 HOH HOH A . 
F 5 HOH 1  401 404 HOH HOH B . 
F 5 HOH 2  402 397 HOH HOH B . 
F 5 HOH 3  403 364 HOH HOH B . 
F 5 HOH 4  404 359 HOH HOH B . 
F 5 HOH 5  405 403 HOH HOH B . 
F 5 HOH 6  406 358 HOH HOH B . 
F 5 HOH 7  407 363 HOH HOH B . 
F 5 HOH 8  408 391 HOH HOH B . 
F 5 HOH 9  409 394 HOH HOH B . 
F 5 HOH 10 410 400 HOH HOH B . 
F 5 HOH 11 411 349 HOH HOH B . 
F 5 HOH 12 412 366 HOH HOH B . 
F 5 HOH 13 413 408 HOH HOH B . 
F 5 HOH 14 414 381 HOH HOH B . 
F 5 HOH 15 415 385 HOH HOH B . 
F 5 HOH 16 416 361 HOH HOH B . 
F 5 HOH 17 417 345 HOH HOH B . 
F 5 HOH 18 418 347 HOH HOH B . 
F 5 HOH 19 419 351 HOH HOH B . 
F 5 HOH 20 420 355 HOH HOH B . 
F 5 HOH 21 421 384 HOH HOH B . 
F 5 HOH 22 422 357 HOH HOH B . 
F 5 HOH 23 423 406 HOH HOH B . 
F 5 HOH 24 424 365 HOH HOH B . 
F 5 HOH 25 425 387 HOH HOH B . 
F 5 HOH 26 426 377 HOH HOH B . 
F 5 HOH 27 427 380 HOH HOH B . 
F 5 HOH 28 428 344 HOH HOH B . 
F 5 HOH 29 429 369 HOH HOH B . 
F 5 HOH 30 430 399 HOH HOH B . 
F 5 HOH 31 431 410 HOH HOH B . 
F 5 HOH 32 432 407 HOH HOH B . 
F 5 HOH 33 433 402 HOH HOH B . 
F 5 HOH 34 434 386 HOH HOH B . 
F 5 HOH 35 435 382 HOH HOH B . 
F 5 HOH 36 436 389 HOH HOH B . 
F 5 HOH 37 437 343 HOH HOH B . 
F 5 HOH 38 438 374 HOH HOH B . 
F 5 HOH 39 439 352 HOH HOH B . 
F 5 HOH 40 440 356 HOH HOH B . 
F 5 HOH 41 441 367 HOH HOH B . 
F 5 HOH 42 442 393 HOH HOH B . 
F 5 HOH 43 443 373 HOH HOH B . 
F 5 HOH 44 444 405 HOH HOH B . 
F 5 HOH 45 445 376 HOH HOH B . 
F 5 HOH 46 446 342 HOH HOH B . 
F 5 HOH 47 447 353 HOH HOH B . 
F 5 HOH 48 448 354 HOH HOH B . 
F 5 HOH 49 449 409 HOH HOH B . 
F 5 HOH 50 450 341 HOH HOH B . 
F 5 HOH 51 451 378 HOH HOH B . 
F 5 HOH 52 452 379 HOH HOH B . 
F 5 HOH 53 453 368 HOH HOH B . 
F 5 HOH 54 454 401 HOH HOH B . 
F 5 HOH 55 455 362 HOH HOH B . 
F 5 HOH 56 456 390 HOH HOH B . 
F 5 HOH 57 457 375 HOH HOH B . 
F 5 HOH 58 458 411 HOH HOH B . 
F 5 HOH 59 459 348 HOH HOH B . 
F 5 HOH 60 460 346 HOH HOH B . 
F 5 HOH 61 461 398 HOH HOH B . 
F 5 HOH 62 462 388 HOH HOH B . 
F 5 HOH 63 463 371 HOH HOH B . 
F 5 HOH 64 464 370 HOH HOH B . 
F 5 HOH 65 465 396 HOH HOH B . 
F 5 HOH 66 466 383 HOH HOH B . 
F 5 HOH 67 467 372 HOH HOH B . 
F 5 HOH 68 468 392 HOH HOH B . 
F 5 HOH 69 469 360 HOH HOH B . 
F 5 HOH 70 470 350 HOH HOH B . 
F 5 HOH 71 471 395 HOH HOH B . 
G 5 HOH 1  301 269 HOH HOH C . 
G 5 HOH 2  302 268 HOH HOH C . 
G 5 HOH 3  303 293 HOH HOH C . 
G 5 HOH 4  304 297 HOH HOH C . 
G 5 HOH 5  305 258 HOH HOH C . 
G 5 HOH 6  306 265 HOH HOH C . 
G 5 HOH 7  307 263 HOH HOH C . 
G 5 HOH 8  308 288 HOH HOH C . 
G 5 HOH 9  309 281 HOH HOH C . 
G 5 HOH 10 310 255 HOH HOH C . 
G 5 HOH 11 311 245 HOH HOH C . 
G 5 HOH 12 312 286 HOH HOH C . 
G 5 HOH 13 313 295 HOH HOH C . 
G 5 HOH 14 314 273 HOH HOH C . 
G 5 HOH 15 315 277 HOH HOH C . 
G 5 HOH 16 316 294 HOH HOH C . 
G 5 HOH 17 317 284 HOH HOH C . 
G 5 HOH 18 318 243 HOH HOH C . 
G 5 HOH 19 319 254 HOH HOH C . 
G 5 HOH 20 320 289 HOH HOH C . 
G 5 HOH 21 321 260 HOH HOH C . 
G 5 HOH 22 322 259 HOH HOH C . 
G 5 HOH 23 323 261 HOH HOH C . 
G 5 HOH 24 324 237 HOH HOH C . 
G 5 HOH 25 325 291 HOH HOH C . 
G 5 HOH 26 326 283 HOH HOH C . 
G 5 HOH 27 327 249 HOH HOH C . 
G 5 HOH 28 328 250 HOH HOH C . 
G 5 HOH 29 329 251 HOH HOH C . 
G 5 HOH 30 330 271 HOH HOH C . 
G 5 HOH 31 331 247 HOH HOH C . 
G 5 HOH 32 332 279 HOH HOH C . 
G 5 HOH 33 333 244 HOH HOH C . 
G 5 HOH 34 334 287 HOH HOH C . 
G 5 HOH 35 335 285 HOH HOH C . 
G 5 HOH 36 336 299 HOH HOH C . 
G 5 HOH 37 337 275 HOH HOH C . 
G 5 HOH 38 338 292 HOH HOH C . 
G 5 HOH 39 339 248 HOH HOH C . 
G 5 HOH 40 340 264 HOH HOH C . 
G 5 HOH 41 341 272 HOH HOH C . 
G 5 HOH 42 342 327 HOH HOH C . 
G 5 HOH 43 343 274 HOH HOH C . 
G 5 HOH 44 344 241 HOH HOH C . 
G 5 HOH 45 345 282 HOH HOH C . 
G 5 HOH 46 346 278 HOH HOH C . 
G 5 HOH 47 347 239 HOH HOH C . 
G 5 HOH 48 348 256 HOH HOH C . 
G 5 HOH 49 349 257 HOH HOH C . 
G 5 HOH 50 350 240 HOH HOH C . 
G 5 HOH 51 351 266 HOH HOH C . 
G 5 HOH 52 352 280 HOH HOH C . 
G 5 HOH 53 353 296 HOH HOH C . 
G 5 HOH 54 354 246 HOH HOH C . 
G 5 HOH 55 355 238 HOH HOH C . 
G 5 HOH 56 356 276 HOH HOH C . 
G 5 HOH 57 357 267 HOH HOH C . 
G 5 HOH 58 358 253 HOH HOH C . 
G 5 HOH 59 359 242 HOH HOH C . 
G 5 HOH 60 360 262 HOH HOH C . 
G 5 HOH 61 361 252 HOH HOH C . 
G 5 HOH 62 362 236 HOH HOH C . 
G 5 HOH 63 363 290 HOH HOH C . 
G 5 HOH 64 364 298 HOH HOH C . 
G 5 HOH 65 365 270 HOH HOH C . 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9H94 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9H94 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9H94 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9H94 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.10 
_refine.ls_d_res_low                             ? 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    ? 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       ? 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'REAL-SPACE (WEIGHTED MAP SUM AT ATOM CENTERS)' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           ? 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.003  ? 35166 ? f_bond_d           ? ? 
'ELECTRON MICROSCOPY' ? 0.533  ? 47940 ? f_angle_d          ? ? 
'ELECTRON MICROSCOPY' ? 11.245 ? 12726 ? f_dihedral_angle_d ? ? 
'ELECTRON MICROSCOPY' ? 0.043  ? 5280  ? f_chiral_restr     ? ? 
'ELECTRON MICROSCOPY' ? 0.004  ? 6174  ? f_plane_restr      ? ? 
# 
_struct.entry_id                     9H94 
_struct.title                        
'Poliovirus type 2 (strain MEF-1) stabilised virus-like particle (PV2 SC5a) from a yeast expression system.' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9H94 
_struct_keywords.text            'Capsid protein, virus-like particle, vaccine, VIRUS LIKE PARTICLE' 
_struct_keywords.pdbx_keywords   'VIRUS LIKE PARTICLE' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 5 ? 
F N N 5 ? 
G N N 5 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP Q8QNU4_9ENTO     Q8QNU4     ? 1 
;GLGDLIEGVVEGVTRNALTPLTPANNLPDTQSSGPAHSKETPALTAVETGATNPLVPSDTVQTRHVIQKRTRSESTVESF
FARGACVAIIEVDNDAPTKRASKLFSVWKITYKDTVQLRRKLEFFTYSRFDMEFTFVVTSNYTDANNGHALNQVYQIMYI
PPGAPIPGKWNDYTWQTSSNPSVFYTYGAPPARISVPYVGIANAYSHFYDGFAKVPLAGQASTEGDSLYGAASLNDFGSL
AVRVVNDHNPTKLTSKIRVYMKPKHVRVWCPRPPRAVPYYGPGVDYKDGLAPLPEKGLTTY
;
1   
2 UNP POLG_POL2L       P06210     ? 2 
;MGAQVSSQKVGAHENSNRAYGGSTINYTTINYYRDSASNAASKQDFAQDPSKFTEPIKDVLIKTAPTLNSPNIEACGYSD
RVMQLTLGNSTITTQEAANSVVAYGRWPEYIKDSEANPVDQPTEPDVAACRFYTLDTVTWRKESRGWWWKLPDALKDMGL
FGQNMFYHYLGRAGYTVHVQCNASKFHQGALGVFAVPEMCLAGDSTTHMFTKYENANPGEKGGEFKGSFTLDTNATNPAR
NFCPVDYLFGSGVLAGNAFVYPHQIINLRTNNCATLVLPYVNSLSIDSMTKHNNWGIAILPLAPLDFATESSTEIPITLT
IAPMCCEFNGLRNITVPRTQ
;
1   
3 UNP A0A0K1U2R1_9ENTO A0A0K1U2R1 ? 3 
;GLPVLNTPGSNQYLTADNYQSPCAIPEFDVTPPIDIPGEVRNMMELAEIDTMIPLNLTNQRKNTMDMYRVELNDAAHSDT
PILCLSLSPASDPRLAHTMLGEILNYYTHWAGSLKFTFLFCGSMMATGKLLVSYAPPGAEAPKSRKEAMLGTHVIWDIGL
QSSCTMVVPWISNTTYRQTINDSFTEGGYISMFYQTRVVVPLSTPRKMDILGFVSACNDFSVRLLRDTTHISQEAMPQ
;
341 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9H94 A 1 ? 301 ? Q8QNU4     1   ? 301 ? 1 301 
2 2 9H94 B 1 ? 340 ? P06210     1   ? 340 ? 1 340 
3 3 9H94 C 1 ? 238 ? A0A0K1U2R1 341 ? 578 ? 1 238 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9H94 ILE A 41  ? UNP Q8QNU4     THR 41  'engineered mutation' 41  1 
1 9H94 LEU A 134 ? UNP Q8QNU4     PHE 134 'engineered mutation' 134 2 
1 9H94 PHE A 159 ? UNP Q8QNU4     TYR 159 'engineered mutation' 159 3 
3 9H94 PHE C 85  ? UNP A0A0K1U2R1 LEU 425 'engineered mutation' 85  4 
3 9H94 LEU C 178 ? UNP A0A0K1U2R1 GLN 518 'engineered mutation' 178 5 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   180-meric 
_pdbx_struct_assembly.oligomeric_count     180 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   
;1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60
;
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1  'identity operation'       1_555 x,y,z 1.0       0.0       0.0       0.0        0.0       1.0       0.0       0.0        0.0 
0.0       1.0       0.0        
2  'point symmetry operation' ?     ?     -0.809017 -0.500000 0.309017  478.08000  -0.500000 0.309017  -0.809017 478.08000  
0.309017  -0.809017 -0.500000 478.08000  
3  'point symmetry operation' ?     ?     0.0       1.0       0.0       0.0        0.0       0.0       -1.0      478.08000  -1.0 
0.0       0.0       478.08000  
4  'point symmetry operation' ?     ?     0.809017  -0.500000 -0.309017 239.04000  -0.500000 -0.309017 -0.809017 625.81484  
0.309017  0.809017  -0.500000 91.30516   
5  'point symmetry operation' ?     ?     0.500000  0.309017  -0.809017 239.04000  -0.309017 -0.809017 -0.500000 625.81484  
-0.809017 0.500000  -0.309017 386.77484  
6  'point symmetry operation' ?     ?     -0.309017 -0.809017 -0.500000 625.81484  -0.809017 0.500000  -0.309017 386.77484  
0.500000  0.309017  -0.809017 239.04000  
7  'point symmetry operation' ?     ?     -0.809017 0.500000  -0.309017 386.77484  0.500000  0.309017  -0.809017 239.04000  
-0.309017 -0.809017 -0.500000 625.81484  
8  'point symmetry operation' ?     ?     -0.809017 -0.500000 -0.309017 625.81484  0.500000  -0.309017 -0.809017 386.77484  
0.309017  -0.809017 0.500000  239.04000  
9  'point symmetry operation' ?     ?     -0.309017 0.809017  -0.500000 239.04000  -0.809017 -0.500000 -0.309017 625.81484  
-0.500000 0.309017  0.809017  91.30516   
10 'point symmetry operation' ?     ?     0.500000  -0.309017 -0.809017 386.77484  -0.309017 0.809017  -0.500000 239.04000  
0.809017  0.500000  0.309017  -147.73484 
11 'point symmetry operation' ?     ?     0.0       0.0       -1.0      478.08000  -1.0      0.0       0.0       478.08000  0.0 
1.0       0.0       0.0        
12 'point symmetry operation' ?     ?     -0.500000 -0.309017 -0.809017 625.81484  0.309017  0.809017  -0.500000 91.30516   
0.809017  -0.500000 -0.309017 239.04000  
13 'point symmetry operation' ?     ?     -0.500000 0.309017  -0.809017 478.08000  0.309017  -0.809017 -0.500000 478.08000  
-0.809017 -0.500000 0.309017  478.08000  
14 'point symmetry operation' ?     ?     -0.309017 -0.809017 -0.500000 625.81484  0.809017  -0.500000 0.309017  91.30516   
-0.500000 -0.309017 0.809017  239.04000  
15 'point symmetry operation' ?     ?     -0.809017 0.500000  -0.309017 386.77484  -0.500000 -0.309017 0.809017  239.04000  
0.309017  0.809017  0.500000  -147.73484 
16 'point symmetry operation' ?     ?     0.500000  0.309017  -0.809017 239.04000  0.309017  0.809017  0.500000  -147.73484 
0.809017  -0.500000 0.309017  91.30516   
17 'point symmetry operation' ?     ?     -0.500000 0.309017  -0.809017 478.08000  -0.309017 0.809017  0.500000  0.0        
0.809017  0.500000  -0.309017 0.0        
18 'point symmetry operation' ?     ?     0.0       0.0       -1.0      478.08000  1.0       0.0       0.0       0.0        0.0 
-1.0      0.0       478.08000  
19 'point symmetry operation' ?     ?     -0.500000 -0.309017 -0.809017 625.81484  -0.309017 -0.809017 0.500000  386.77484  
-0.809017 0.500000  0.309017  239.04000  
20 'point symmetry operation' ?     ?     0.0       -1.0      0.0       478.08000  0.0       0.0       1.0       0.0        -1.0 
0.0       0.0       478.08000  
21 'point symmetry operation' ?     ?     -0.809017 0.500000  0.309017  239.04000  0.500000  0.309017  0.809017  -147.73484 
0.309017  0.809017  -0.500000 91.30516   
22 'point symmetry operation' ?     ?     0.809017  0.500000  -0.309017 0.0        0.500000  -0.309017 0.809017  0.0        
0.309017  -0.809017 -0.500000 478.08000  
23 'point symmetry operation' ?     ?     -0.309017 0.809017  -0.500000 239.04000  0.809017  0.500000  0.309017  -147.73484 
0.500000  -0.309017 -0.809017 386.77484  
24 'point symmetry operation' ?     ?     0.500000  -0.309017 -0.809017 386.77484  0.309017  -0.809017 0.500000  239.04000  
-0.809017 -0.500000 -0.309017 625.81484  
25 'point symmetry operation' ?     ?     -0.809017 -0.500000 -0.309017 625.81484  -0.500000 0.309017  0.809017  91.30516   
-0.309017 0.809017  -0.500000 239.04000  
26 'point symmetry operation' ?     ?     -0.309017 -0.809017 0.500000  386.77484  -0.809017 0.500000  0.309017  239.04000  
-0.500000 -0.309017 -0.809017 625.81484  
27 'point symmetry operation' ?     ?     -0.309017 0.809017  0.500000  0.0        0.809017  0.500000  -0.309017 0.0        
-0.500000 0.309017  -0.809017 478.08000  
28 'point symmetry operation' ?     ?     1.0       0.0       0.0       0.0        0.0       -1.0      0.0       478.08000  0.0 
0.0       -1.0      478.08000  
29 'point symmetry operation' ?     ?     0.309017  0.809017  -0.500000 91.30516   0.809017  -0.500000 -0.309017 239.04000  
-0.500000 -0.309017 -0.809017 625.81484  
30 'point symmetry operation' ?     ?     0.309017  -0.809017 -0.500000 478.08000  -0.809017 -0.500000 0.309017  478.08000  
-0.500000 0.309017  -0.809017 478.08000  
31 'point symmetry operation' ?     ?     -1.0      0.0       0.0       478.08000  0.0       1.0       0.0       0.0        0.0 
0.0       -1.0      478.08000  
32 'point symmetry operation' ?     ?     0.809017  0.500000  -0.309017 0.0        -0.500000 0.309017  -0.809017 478.08000  
-0.309017 0.809017  0.500000  0.0        
33 'point symmetry operation' ?     ?     0.0       -1.0      0.0       478.08000  0.0       0.0       -1.0      478.08000  1.0 
0.0       0.0       0.0        
34 'point symmetry operation' ?     ?     -0.809017 0.500000  0.309017  239.04000  -0.500000 -0.309017 -0.809017 625.81484  
-0.309017 -0.809017 0.500000  386.77484  
35 'point symmetry operation' ?     ?     -0.500000 -0.309017 0.809017  239.04000  -0.309017 -0.809017 -0.500000 625.81484  
0.809017  -0.500000 0.309017  91.30516   
36 'point symmetry operation' ?     ?     0.309017  0.809017  0.500000  -147.73484 -0.809017 0.500000  -0.309017 386.77484  
-0.500000 -0.309017 0.809017  239.04000  
37 'point symmetry operation' ?     ?     0.809017  -0.500000 0.309017  91.30516   0.500000  0.309017  -0.809017 239.04000  
0.309017  0.809017  0.500000  -147.73484 
38 'point symmetry operation' ?     ?     0.809017  0.500000  0.309017  -147.73484 0.500000  -0.309017 -0.809017 386.77484  
-0.309017 0.809017  -0.500000 239.04000  
39 'point symmetry operation' ?     ?     0.309017  -0.809017 0.500000  239.04000  -0.809017 -0.500000 -0.309017 625.81484  
0.500000  -0.309017 -0.809017 386.77484  
40 'point symmetry operation' ?     ?     -0.500000 0.309017  0.809017  91.30516   -0.309017 0.809017  -0.500000 239.04000  
-0.809017 -0.500000 -0.309017 625.81484  
41 'point symmetry operation' ?     ?     0.0       0.0       1.0       0.0        -1.0      0.0       0.0       478.08000  0.0 
-1.0      0.0       478.08000  
42 'point symmetry operation' ?     ?     0.500000  0.309017  0.809017  -147.73484 0.309017  0.809017  -0.500000 91.30516   
-0.809017 0.500000  0.309017  239.04000  
43 'point symmetry operation' ?     ?     0.500000  -0.309017 0.809017  0.0        0.309017  -0.809017 -0.500000 478.08000  
0.809017  0.500000  -0.309017 0.0        
44 'point symmetry operation' ?     ?     0.309017  0.809017  0.500000  -147.73484 0.809017  -0.500000 0.309017  91.30516   
0.500000  0.309017  -0.809017 239.04000  
45 'point symmetry operation' ?     ?     0.809017  -0.500000 0.309017  91.30516   -0.500000 -0.309017 0.809017  239.04000  
-0.309017 -0.809017 -0.500000 625.81484  
46 'point symmetry operation' ?     ?     -0.500000 -0.309017 0.809017  239.04000  0.309017  0.809017  0.500000  -147.73484 
-0.809017 0.500000  -0.309017 386.77484  
47 'point symmetry operation' ?     ?     0.500000  -0.309017 0.809017  0.0        -0.309017 0.809017  0.500000  0.0        
-0.809017 -0.500000 0.309017  478.08000  
48 'point symmetry operation' ?     ?     0.0       0.0       1.0       0.0        1.0       0.0       0.0       0.0        0.0 
1.0       0.0       0.0        
49 'point symmetry operation' ?     ?     0.500000  0.309017  0.809017  -147.73484 -0.309017 -0.809017 0.500000  386.77484  
0.809017  -0.500000 -0.309017 239.04000  
50 'point symmetry operation' ?     ?     0.0       1.0       0.0       0.0        0.0       0.0       1.0       0.0        1.0 
0.0       0.0       0.0        
51 'point symmetry operation' ?     ?     0.809017  -0.500000 -0.309017 239.04000  0.500000  0.309017  0.809017  -147.73484 
-0.309017 -0.809017 0.500000  386.77484  
52 'point symmetry operation' ?     ?     -0.809017 -0.500000 0.309017  478.08000  0.500000  -0.309017 0.809017  0.0        
-0.309017 0.809017  0.500000  0.0        
53 'point symmetry operation' ?     ?     0.309017  -0.809017 0.500000  239.04000  0.809017  0.500000  0.309017  -147.73484 
-0.500000 0.309017  0.809017  91.30516   
54 'point symmetry operation' ?     ?     -0.500000 0.309017  0.809017  91.30516   0.309017  -0.809017 0.500000  239.04000  
0.809017  0.500000  0.309017  -147.73484 
55 'point symmetry operation' ?     ?     0.809017  0.500000  0.309017  -147.73484 -0.500000 0.309017  0.809017  91.30516   
0.309017  -0.809017 0.500000  239.04000  
56 'point symmetry operation' ?     ?     0.309017  0.809017  -0.500000 91.30516   -0.809017 0.500000  0.309017  239.04000  
0.500000  0.309017  0.809017  -147.73484 
57 'point symmetry operation' ?     ?     0.309017  -0.809017 -0.500000 478.08000  0.809017  0.500000  -0.309017 0.0        
0.500000  -0.309017 0.809017  0.0        
58 'point symmetry operation' ?     ?     -1.0      0.0       0.0       478.08000  0.0       -1.0      0.0       478.08000  0.0 
0.0       1.0       0.0        
59 'point symmetry operation' ?     ?     -0.309017 -0.809017 0.500000  386.77484  0.809017  -0.500000 -0.309017 239.04000  
0.500000  0.309017  0.809017  -147.73484 
60 'point symmetry operation' ?     ?     -0.309017 0.809017  0.500000  0.0        -0.809017 -0.500000 0.309017  478.08000  
0.500000  -0.309017 0.809017  0.0        
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ARG A 72  ? SER A 75  ? ARG A 72  SER A 75  5 ? 4  
HELX_P HELX_P2  AA2 THR A 76  ? PHE A 81  ? THR A 76  PHE A 81  1 ? 6  
HELX_P HELX_P3  AA3 ALA A 96  ? ARG A 100 ? ALA A 96  ARG A 100 5 ? 5  
HELX_P HELX_P4  AA4 VAL A 116 ? PHE A 124 ? VAL A 116 PHE A 124 1 ? 9  
HELX_P HELX_P5  AA5 ASP A 172 ? THR A 177 ? ASP A 172 THR A 177 5 ? 6  
HELX_P HELX_P6  AA6 ALA A 232 ? ASP A 236 ? ALA A 232 ASP A 236 5 ? 5  
HELX_P HELX_P7  AA7 TYR B 104 ? ARG B 106 ? TYR B 104 ARG B 106 5 ? 3  
HELX_P HELX_P8  AA8 PRO B 125 ? ALA B 129 ? PRO B 125 ALA B 129 5 ? 5  
HELX_P HELX_P9  AA9 PRO B 152 ? LYS B 156 ? PRO B 152 LYS B 156 5 ? 5  
HELX_P HELX_P10 AB1 MET B 158 ? TYR B 167 ? MET B 158 TYR B 167 1 ? 10 
HELX_P HELX_P11 AB2 LYS B 212 ? ASN B 217 ? LYS B 212 ASN B 217 1 ? 6  
HELX_P HELX_P12 AB3 PRO B 218 ? GLY B 222 ? PRO B 218 GLY B 222 5 ? 5  
HELX_P HELX_P13 AB4 LEU B 254 ? TYR B 261 ? LEU B 254 TYR B 261 5 ? 8  
HELX_P HELX_P14 AB5 ASN C 42  ? GLU C 48  ? ASN C 42  GLU C 48  1 ? 7  
HELX_P HELX_P15 AB6 THR C 64  ? MET C 67  ? THR C 64  MET C 67  5 ? 4  
HELX_P HELX_P16 AB7 ASP C 92  ? HIS C 97  ? ASP C 92  HIS C 97  1 ? 6  
HELX_P HELX_P17 AB8 THR C 98  ? ASN C 105 ? THR C 98  ASN C 105 1 ? 8  
HELX_P HELX_P18 AB9 SER C 144 ? MET C 149 ? SER C 144 MET C 149 1 ? 6  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          LEU 
_struct_mon_prot_cis.label_seq_id           151 
_struct_mon_prot_cis.label_asym_id          B 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           LEU 
_struct_mon_prot_cis.auth_seq_id            151 
_struct_mon_prot_cis.auth_asym_id           B 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    152 
_struct_mon_prot_cis.pdbx_label_asym_id_2   B 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     152 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    B 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       8.08 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 4 ? 
AA3 ? 4 ? 
AA4 ? 2 ? 
AA5 ? 5 ? 
AA6 ? 5 ? 
AA7 ? 5 ? 
AA8 ? 3 ? 
AA9 ? 4 ? 
AB1 ? 4 ? 
AB2 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA5 1 2 ? parallel      
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA5 4 5 ? anti-parallel 
AA6 1 2 ? parallel      
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
AA6 4 5 ? anti-parallel 
AA7 1 2 ? anti-parallel 
AA7 2 3 ? anti-parallel 
AA7 3 4 ? anti-parallel 
AA7 4 5 ? anti-parallel 
AA8 1 2 ? anti-parallel 
AA8 2 3 ? anti-parallel 
AA9 1 2 ? anti-parallel 
AA9 2 3 ? anti-parallel 
AA9 3 4 ? anti-parallel 
AB1 1 2 ? anti-parallel 
AB1 2 3 ? anti-parallel 
AB1 3 4 ? anti-parallel 
AB2 1 2 ? anti-parallel 
AB2 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ALA A 85  ? ASN A 94  ? ALA A 85  ASN A 94  
AA1 2 LEU A 253 ? PRO A 271 ? LEU A 253 PRO A 271 
AA1 3 PHE A 125 ? TYR A 142 ? PHE A 125 TYR A 142 
AA1 4 TYR A 205 ? SER A 206 ? TYR A 205 SER A 206 
AA2 1 ALA A 192 ? VAL A 196 ? ALA A 192 VAL A 196 
AA2 2 PHE A 125 ? TYR A 142 ? PHE A 125 TYR A 142 
AA2 3 LEU A 253 ? PRO A 271 ? LEU A 253 PRO A 271 
AA2 4 GLU C 39  ? VAL C 40  ? GLU C 39  VAL C 40  
AA3 1 PHE A 105 ? LYS A 109 ? PHE A 105 LYS A 109 
AA3 2 SER A 239 ? VAL A 244 ? SER A 239 VAL A 244 
AA3 3 VAL A 154 ? ILE A 160 ? VAL A 154 ILE A 160 
AA3 4 SER A 182 ? THR A 186 ? SER A 182 THR A 186 
AA4 1 LEU B 85  ? LEU B 87  ? LEU B 85  LEU B 87  
AA4 2 SER B 90  ? ILE B 92  ? SER B 90  ILE B 92  
AA5 1 SER B 100 ? VAL B 102 ? SER B 100 VAL B 102 
AA5 2 CYS B 273 ? LEU B 278 ? CYS B 273 LEU B 278 
AA5 3 HIS B 168 ? GLN B 180 ? HIS B 168 GLN B 180 
AA5 4 GLU B 314 ? LEU B 331 ? GLU B 314 LEU B 331 
AA5 5 TYR B 133 ? THR B 134 ? TYR B 133 THR B 134 
AA6 1 SER B 100 ? VAL B 102 ? SER B 100 VAL B 102 
AA6 2 CYS B 273 ? LEU B 278 ? CYS B 273 LEU B 278 
AA6 3 HIS B 168 ? GLN B 180 ? HIS B 168 GLN B 180 
AA6 4 GLU B 314 ? LEU B 331 ? GLU B 314 LEU B 331 
AA6 5 VAL B 138 ? ARG B 141 ? VAL B 138 ARG B 141 
AA7 1 GLY B 223 ? GLU B 224 ? GLY B 223 GLU B 224 
AA7 2 TRP B 147 ? LEU B 151 ? TRP B 147 LEU B 151 
AA7 3 TRP B 295 ? PHE B 307 ? TRP B 295 PHE B 307 
AA7 4 HIS B 187 ? PRO B 197 ? HIS B 187 PRO B 197 
AA7 5 HIS B 263 ? ASN B 267 ? HIS B 263 ASN B 267 
AA8 1 THR C 51  ? MET C 52  ? THR C 51  MET C 52  
AA8 2 LYS C 207 ? ALA C 216 ? LYS C 207 ALA C 216 
AA8 3 ARG C 69  ? ASN C 73  ? ARG C 69  ASN C 73  
AA9 1 THR C 51  ? MET C 52  ? THR C 51  MET C 52  
AA9 2 LYS C 207 ? ALA C 216 ? LYS C 207 ALA C 216 
AA9 3 LEU C 114 ? PHE C 120 ? LEU C 114 PHE C 120 
AA9 4 SER C 163 ? VAL C 168 ? SER C 163 VAL C 168 
AB1 1 PRO C 81  ? SER C 86  ? PRO C 81  SER C 86  
AB1 2 TYR C 189 ? TYR C 194 ? TYR C 189 TYR C 194 
AB1 3 LYS C 129 ? ALA C 135 ? LYS C 129 ALA C 135 
AB1 4 THR C 152 ? ASP C 157 ? THR C 152 ASP C 157 
AB2 1 ARG C 177 ? LEU C 178 ? ARG C 177 LEU C 178 
AB2 2 TYR C 107 ? ALA C 111 ? TYR C 107 ALA C 111 
AB2 3 SER C 221 ? LEU C 225 ? SER C 221 LEU C 225 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N VAL A 87  ? N VAL A 87  O VAL A 259 ? O VAL A 259 
AA1 2 3 O ARG A 258 ? O ARG A 258 N VAL A 137 ? N VAL A 137 
AA1 3 4 N SER A 128 ? N SER A 128 O TYR A 205 ? O TYR A 205 
AA2 1 2 O ALA A 192 ? O ALA A 192 N PHE A 136 ? N PHE A 136 
AA2 2 3 N VAL A 137 ? N VAL A 137 O ARG A 258 ? O ARG A 258 
AA2 3 4 N VAL A 268 ? N VAL A 268 O VAL C 40  ? O VAL C 40  
AA3 1 2 N SER A 106 ? N SER A 106 O VAL A 242 ? O VAL A 242 
AA3 2 3 O ALA A 241 ? O ALA A 241 N MET A 158 ? N MET A 158 
AA3 3 4 N TYR A 155 ? N TYR A 155 O TYR A 185 ? O TYR A 185 
AA4 1 2 N LEU B 87  ? N LEU B 87  O SER B 90  ? O SER B 90  
AA5 1 2 N VAL B 101 ? N VAL B 101 O VAL B 277 ? O VAL B 277 
AA5 2 3 O LEU B 276 ? O LEU B 276 N VAL B 177 ? N VAL B 177 
AA5 3 4 N LEU B 170 ? N LEU B 170 O ASN B 329 ? O ASN B 329 
AA5 4 5 O ILE B 321 ? O ILE B 321 N TYR B 133 ? N TYR B 133 
AA6 1 2 N VAL B 101 ? N VAL B 101 O VAL B 277 ? O VAL B 277 
AA6 2 3 O LEU B 276 ? O LEU B 276 N VAL B 177 ? N VAL B 177 
AA6 3 4 N LEU B 170 ? N LEU B 170 O ASN B 329 ? O ASN B 329 
AA6 4 5 O ILE B 315 ? O ILE B 315 N TRP B 140 ? N TRP B 140 
AA7 1 2 O GLY B 223 ? O GLY B 223 N TRP B 148 ? N TRP B 148 
AA7 2 3 N LEU B 151 ? N LEU B 151 O TRP B 295 ? O TRP B 295 
AA7 3 4 O ALA B 298 ? O ALA B 298 N PHE B 194 ? N PHE B 194 
AA7 4 5 N VAL B 193 ? N VAL B 193 O GLN B 264 ? O GLN B 264 
AA8 1 2 N THR C 51  ? N THR C 51  O VAL C 214 ? O VAL C 214 
AA8 2 3 O MET C 208 ? O MET C 208 N LEU C 72  ? N LEU C 72  
AA9 1 2 N THR C 51  ? N THR C 51  O VAL C 214 ? O VAL C 214 
AA9 2 3 O SER C 215 ? O SER C 215 N LYS C 115 ? N LYS C 115 
AA9 3 4 N PHE C 116 ? N PHE C 116 O MET C 166 ? O MET C 166 
AB1 1 2 N ILE C 82  ? N ILE C 82  O MET C 192 ? O MET C 192 
AB1 2 3 O SER C 191 ? O SER C 191 N SER C 133 ? N SER C 133 
AB1 3 4 N LEU C 130 ? N LEU C 130 O TRP C 156 ? O TRP C 156 
AB2 1 2 O ARG C 177 ? O ARG C 177 N TRP C 110 ? N TRP C 110 
AB2 2 3 N ALA C 111 ? N ALA C 111 O SER C 221 ? O SER C 221 
# 
_pdbx_entry_details.entry_id                   9H94 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ARG A 100 ? ? 74.19   -6.84   
2 1 CYS A 270 ? ? 61.71   74.34   
3 1 ASP B 126 ? ? 57.44   -124.92 
4 1 SER B 251 ? ? -141.15 21.12   
5 1 LEU C 57  ? ? -95.99  51.93   
6 1 THR C 196 ? ? -115.73 -73.46  
7 1 ARG C 197 ? ? 174.46  161.79  
8 1 LEU C 224 ? ? 61.62   68.82   
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9H94 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   'Cross-correlation coefficient' 
_em_3d_fitting.details           
;Initial model was rigid body fitted using UCSF chimera and Coot.  Global minimization and B-factor refinement 
was performed in real space using phenix_real.space.refine.
;
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         REAL 
_em_3d_fitting.ref_protocol      'RIGID BODY FIT' 
# 
_em_3d_fitting_list.id                            1 
_em_3d_fitting_list.3d_fitting_id                 1 
_em_3d_fitting_list.pdb_entry_id                  1EAH 
_em_3d_fitting_list.pdb_chain_id                  ? 
_em_3d_fitting_list.pdb_chain_residue_range       ? 
_em_3d_fitting_list.details                       ? 
_em_3d_fitting_list.chain_id                      ? 
_em_3d_fitting_list.chain_residue_range           ? 
_em_3d_fitting_list.source_name                   PDB 
_em_3d_fitting_list.type                          'experimental model' 
_em_3d_fitting_list.accession_code                1EAH 
_em_3d_fitting_list.initial_refinement_model_id   1 
# 
_em_3d_reconstruction.entry_id                    9H94 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   'BACK PROJECTION' 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     
;Icosahedral symmetry applied to final reconstruction. Final maps were post-processed with an inverse B-factor of -94.4 Angstrom squared.
;
_em_3d_reconstruction.resolution                  2.1 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               147409 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          1 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       '1 x DPBS, 20 mM EDTA, pH 7.0' 
_em_buffer.pH            7.0 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 VIRUS 
_em_entity_assembly.name                 'Poliovirus 2' 
_em_entity_assembly.details              'Recombinantly expressed virus-like particle of poliovirus type 2 (MEF-1 strain).' 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1,2,3 
# 
_em_image_scans.entry_id                9H94 
_em_image_scans.id                      1 
_em_image_scans.number_digital_images   ? 
_em_image_scans.details                 ? 
_em_image_scans.scanner_model           ? 
_em_image_scans.sampling_size           5.0 
_em_image_scans.od_range                ? 
_em_image_scans.quant_bit_size          ? 
_em_image_scans.citation_id             ? 
_em_image_scans.dimension_height        ? 
_em_image_scans.dimension_width         ? 
_em_image_scans.frames_per_image        ? 
_em_image_scans.image_recording_id      1 
_em_image_scans.used_frames_per_image   ? 
# 
_em_imaging.entry_id                        9H94 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'TFS KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           'FEI TITAN KRIOS AUTOGRID HOLDER' 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'DARK FIELD' 
_em_imaging.nominal_cs                      2.7 
_em_imaging.nominal_defocus_min             500 
_em_imaging.nominal_defocus_max             2300 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           150000 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             'COMA FREE' 
_em_imaging.c2_aperture_diameter            100 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         NITROGEN 
# 
_em_sample_support.id               1 
_em_sample_support.film_material    ? 
_em_sample_support.method           ? 
_em_sample_support.grid_material    COPPER 
_em_sample_support.grid_mesh_size   200 
_em_sample_support.grid_type        'Quantifoil R2/1' 
_em_sample_support.details          ? 
_em_sample_support.specimen_id      1 
_em_sample_support.citation_id      ? 
# 
_em_virus_entity.id                    1 
_em_virus_entity.virus_host_category   ? 
_em_virus_entity.virus_type            'VIRUS-LIKE PARTICLE' 
_em_virus_entity.virus_isolate         SEROTYPE 
_em_virus_entity.entity_assembly_id    1 
_em_virus_entity.enveloped             NO 
_em_virus_entity.empty                 YES 
_em_virus_entity.details               ? 
# 
_em_vitrification.entry_id              9H94 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE-PROPANE 
_em_vitrification.humidity              100 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   277.15 
_em_vitrification.instrument            'FEI VITROBOT MARK IV' 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               '3ul of sample double blotted for 3.5 seconds with -15 blot force on FEI Vitrobot mark IV.' 
# 
_em_experiment.entry_id                9H94 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
_em_single_particle_entity.entry_id              9H94 
_em_single_particle_entity.id                    1 
_em_single_particle_entity.image_processing_id   1 
_em_single_particle_entity.point_symmetry        I 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A GLY 1   ? A GLY 1   
2   1 Y 1 A LEU 2   ? A LEU 2   
3   1 Y 1 A GLY 3   ? A GLY 3   
4   1 Y 1 A ASP 4   ? A ASP 4   
5   1 Y 1 A LEU 5   ? A LEU 5   
6   1 Y 1 A ILE 6   ? A ILE 6   
7   1 Y 1 A GLU 7   ? A GLU 7   
8   1 Y 1 A GLY 8   ? A GLY 8   
9   1 Y 1 A VAL 9   ? A VAL 9   
10  1 Y 1 A VAL 10  ? A VAL 10  
11  1 Y 1 A GLU 11  ? A GLU 11  
12  1 Y 1 A GLY 12  ? A GLY 12  
13  1 Y 1 A VAL 13  ? A VAL 13  
14  1 Y 1 A THR 14  ? A THR 14  
15  1 Y 1 A ARG 15  ? A ARG 15  
16  1 Y 1 A ASN 16  ? A ASN 16  
17  1 Y 1 A ALA 17  ? A ALA 17  
18  1 Y 1 A LEU 18  ? A LEU 18  
19  1 Y 1 A THR 19  ? A THR 19  
20  1 Y 1 A PRO 20  ? A PRO 20  
21  1 Y 1 A LEU 21  ? A LEU 21  
22  1 Y 1 A THR 22  ? A THR 22  
23  1 Y 1 A PRO 23  ? A PRO 23  
24  1 Y 1 A ALA 24  ? A ALA 24  
25  1 Y 1 A ASN 25  ? A ASN 25  
26  1 Y 1 A ASN 26  ? A ASN 26  
27  1 Y 1 A LEU 27  ? A LEU 27  
28  1 Y 1 A PRO 28  ? A PRO 28  
29  1 Y 1 A ASP 29  ? A ASP 29  
30  1 Y 1 A THR 30  ? A THR 30  
31  1 Y 1 A GLN 31  ? A GLN 31  
32  1 Y 1 A SER 32  ? A SER 32  
33  1 Y 1 A SER 33  ? A SER 33  
34  1 Y 1 A GLY 34  ? A GLY 34  
35  1 Y 1 A PRO 35  ? A PRO 35  
36  1 Y 1 A ALA 36  ? A ALA 36  
37  1 Y 1 A HIS 37  ? A HIS 37  
38  1 Y 1 A SER 38  ? A SER 38  
39  1 Y 1 A LYS 39  ? A LYS 39  
40  1 Y 1 A GLU 40  ? A GLU 40  
41  1 Y 1 A ILE 41  ? A ILE 41  
42  1 Y 1 A PRO 42  ? A PRO 42  
43  1 Y 1 A ALA 43  ? A ALA 43  
44  1 Y 1 A LEU 44  ? A LEU 44  
45  1 Y 1 A THR 45  ? A THR 45  
46  1 Y 1 A ALA 46  ? A ALA 46  
47  1 Y 1 A VAL 47  ? A VAL 47  
48  1 Y 1 A GLU 48  ? A GLU 48  
49  1 Y 1 A THR 49  ? A THR 49  
50  1 Y 1 A GLY 50  ? A GLY 50  
51  1 Y 1 A ALA 51  ? A ALA 51  
52  1 Y 1 A THR 52  ? A THR 52  
53  1 Y 1 A ASN 53  ? A ASN 53  
54  1 Y 1 A PRO 54  ? A PRO 54  
55  1 Y 1 A LEU 55  ? A LEU 55  
56  1 Y 1 A VAL 56  ? A VAL 56  
57  1 Y 1 A PRO 57  ? A PRO 57  
58  1 Y 1 A SER 58  ? A SER 58  
59  1 Y 1 A ASP 59  ? A ASP 59  
60  1 Y 1 A THR 60  ? A THR 60  
61  1 Y 1 A VAL 61  ? A VAL 61  
62  1 Y 1 B MET 1   ? B MET 1   
63  1 Y 1 B GLY 2   ? B GLY 2   
64  1 Y 1 B ALA 3   ? B ALA 3   
65  1 Y 1 B GLN 4   ? B GLN 4   
66  1 Y 1 B VAL 5   ? B VAL 5   
67  1 Y 1 B SER 6   ? B SER 6   
68  1 Y 1 B SER 7   ? B SER 7   
69  1 Y 1 B GLN 8   ? B GLN 8   
70  1 Y 1 B LYS 9   ? B LYS 9   
71  1 Y 1 B VAL 10  ? B VAL 10  
72  1 Y 1 B GLY 11  ? B GLY 11  
73  1 Y 1 B ALA 12  ? B ALA 12  
74  1 Y 1 B HIS 13  ? B HIS 13  
75  1 Y 1 B GLU 14  ? B GLU 14  
76  1 Y 1 B ASN 15  ? B ASN 15  
77  1 Y 1 B SER 16  ? B SER 16  
78  1 Y 1 B ASN 17  ? B ASN 17  
79  1 Y 1 B ARG 18  ? B ARG 18  
80  1 Y 1 B ALA 19  ? B ALA 19  
81  1 Y 1 B TYR 20  ? B TYR 20  
82  1 Y 1 B GLY 21  ? B GLY 21  
83  1 Y 1 B GLY 22  ? B GLY 22  
84  1 Y 1 B SER 23  ? B SER 23  
85  1 Y 1 B THR 24  ? B THR 24  
86  1 Y 1 B ILE 25  ? B ILE 25  
87  1 Y 1 B ASN 26  ? B ASN 26  
88  1 Y 1 B TYR 27  ? B TYR 27  
89  1 Y 1 B THR 28  ? B THR 28  
90  1 Y 1 B THR 29  ? B THR 29  
91  1 Y 1 B ILE 30  ? B ILE 30  
92  1 Y 1 B ASN 31  ? B ASN 31  
93  1 Y 1 B TYR 32  ? B TYR 32  
94  1 Y 1 B TYR 33  ? B TYR 33  
95  1 Y 1 B ARG 34  ? B ARG 34  
96  1 Y 1 B ASP 35  ? B ASP 35  
97  1 Y 1 B SER 36  ? B SER 36  
98  1 Y 1 B ALA 37  ? B ALA 37  
99  1 Y 1 B SER 38  ? B SER 38  
100 1 Y 1 B ASN 39  ? B ASN 39  
101 1 Y 1 B ALA 40  ? B ALA 40  
102 1 Y 1 B ALA 41  ? B ALA 41  
103 1 Y 1 B SER 42  ? B SER 42  
104 1 Y 1 B LYS 43  ? B LYS 43  
105 1 Y 1 B GLN 44  ? B GLN 44  
106 1 Y 1 B ASP 45  ? B ASP 45  
107 1 Y 1 B PHE 46  ? B PHE 46  
108 1 Y 1 B ALA 47  ? B ALA 47  
109 1 Y 1 B GLN 48  ? B GLN 48  
110 1 Y 1 B ASP 49  ? B ASP 49  
111 1 Y 1 B PRO 50  ? B PRO 50  
112 1 Y 1 B SER 51  ? B SER 51  
113 1 Y 1 B LYS 52  ? B LYS 52  
114 1 Y 1 B PHE 53  ? B PHE 53  
115 1 Y 1 B THR 54  ? B THR 54  
116 1 Y 1 B GLU 55  ? B GLU 55  
117 1 Y 1 B PRO 56  ? B PRO 56  
118 1 Y 1 B ILE 57  ? B ILE 57  
119 1 Y 1 B LYS 58  ? B LYS 58  
120 1 Y 1 B ASP 59  ? B ASP 59  
121 1 Y 1 B VAL 60  ? B VAL 60  
122 1 Y 1 B LEU 61  ? B LEU 61  
123 1 Y 1 B ILE 62  ? B ILE 62  
124 1 Y 1 B LYS 63  ? B LYS 63  
125 1 Y 1 B THR 64  ? B THR 64  
126 1 Y 1 B ALA 65  ? B ALA 65  
127 1 Y 1 B PRO 66  ? B PRO 66  
128 1 Y 1 B THR 67  ? B THR 67  
129 1 Y 1 B LEU 68  ? B LEU 68  
130 1 Y 1 B ASN 69  ? B ASN 69  
131 1 Y 1 B SER 70  ? B SER 70  
132 1 Y 1 B PRO 71  ? B PRO 71  
133 1 Y 1 B ASN 72  ? B ASN 72  
134 1 Y 1 B ILE 73  ? B ILE 73  
135 1 Y 1 B GLU 74  ? B GLU 74  
136 1 Y 1 B ALA 75  ? B ALA 75  
137 1 Y 1 B CYS 76  ? B CYS 76  
138 1 Y 1 B GLY 77  ? B GLY 77  
139 1 Y 1 B TYR 78  ? B TYR 78  
140 1 Y 1 B SER 79  ? B SER 79  
141 1 Y 1 B ASP 80  ? B ASP 80  
142 1 Y 1 B ARG 81  ? B ARG 81  
143 1 Y 1 B VAL 82  ? B VAL 82  
144 1 Y 1 B MET 83  ? B MET 83  
145 1 Y 1 B THR 94  ? B THR 94  
146 1 Y 1 B GLN 95  ? B GLN 95  
147 1 Y 1 B GLU 96  ? B GLU 96  
148 1 Y 1 B ALA 97  ? B ALA 97  
149 1 Y 1 B ALA 98  ? B ALA 98  
150 1 Y 1 B GLU 310 ? B GLU 310 
151 1 Y 1 B SER 311 ? B SER 311 
152 1 Y 1 B SER 312 ? B SER 312 
153 1 Y 1 C MET 236 ? C MET 236 
154 1 Y 1 C PRO 237 ? C PRO 237 
155 1 Y 1 C GLN 238 ? C GLN 238 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
SPH C1   C N N 304 
SPH O1   O N N 305 
SPH C2   C N R 306 
SPH N2   N N N 307 
SPH C3   C N S 308 
SPH O3   O N N 309 
SPH C4   C N N 310 
SPH C5   C N N 311 
SPH C6   C N N 312 
SPH C7   C N N 313 
SPH C8   C N N 314 
SPH C9   C N N 315 
SPH C10  C N N 316 
SPH C11  C N N 317 
SPH C12  C N N 318 
SPH C13  C N N 319 
SPH C14  C N N 320 
SPH C15  C N N 321 
SPH C16  C N N 322 
SPH C17  C N N 323 
SPH C18  C N N 324 
SPH H11  H N N 325 
SPH H12  H N N 326 
SPH HO1  H N N 327 
SPH H2   H N N 328 
SPH HN21 H N N 329 
SPH HN22 H N N 330 
SPH H3   H N N 331 
SPH HO3  H N N 332 
SPH H4   H N N 333 
SPH H5   H N N 334 
SPH H61  H N N 335 
SPH H62  H N N 336 
SPH H71  H N N 337 
SPH H72  H N N 338 
SPH H81  H N N 339 
SPH H82  H N N 340 
SPH H91  H N N 341 
SPH H92  H N N 342 
SPH H101 H N N 343 
SPH H102 H N N 344 
SPH H111 H N N 345 
SPH H112 H N N 346 
SPH H121 H N N 347 
SPH H122 H N N 348 
SPH H131 H N N 349 
SPH H132 H N N 350 
SPH H141 H N N 351 
SPH H142 H N N 352 
SPH H151 H N N 353 
SPH H152 H N N 354 
SPH H161 H N N 355 
SPH H162 H N N 356 
SPH H171 H N N 357 
SPH H172 H N N 358 
SPH H181 H N N 359 
SPH H182 H N N 360 
SPH H183 H N N 361 
THR N    N N N 362 
THR CA   C N S 363 
THR C    C N N 364 
THR O    O N N 365 
THR CB   C N R 366 
THR OG1  O N N 367 
THR CG2  C N N 368 
THR OXT  O N N 369 
THR H    H N N 370 
THR H2   H N N 371 
THR HA   H N N 372 
THR HB   H N N 373 
THR HG1  H N N 374 
THR HG21 H N N 375 
THR HG22 H N N 376 
THR HG23 H N N 377 
THR HXT  H N N 378 
TRP N    N N N 379 
TRP CA   C N S 380 
TRP C    C N N 381 
TRP O    O N N 382 
TRP CB   C N N 383 
TRP CG   C Y N 384 
TRP CD1  C Y N 385 
TRP CD2  C Y N 386 
TRP NE1  N Y N 387 
TRP CE2  C Y N 388 
TRP CE3  C Y N 389 
TRP CZ2  C Y N 390 
TRP CZ3  C Y N 391 
TRP CH2  C Y N 392 
TRP OXT  O N N 393 
TRP H    H N N 394 
TRP H2   H N N 395 
TRP HA   H N N 396 
TRP HB2  H N N 397 
TRP HB3  H N N 398 
TRP HD1  H N N 399 
TRP HE1  H N N 400 
TRP HE3  H N N 401 
TRP HZ2  H N N 402 
TRP HZ3  H N N 403 
TRP HH2  H N N 404 
TRP HXT  H N N 405 
TYR N    N N N 406 
TYR CA   C N S 407 
TYR C    C N N 408 
TYR O    O N N 409 
TYR CB   C N N 410 
TYR CG   C Y N 411 
TYR CD1  C Y N 412 
TYR CD2  C Y N 413 
TYR CE1  C Y N 414 
TYR CE2  C Y N 415 
TYR CZ   C Y N 416 
TYR OH   O N N 417 
TYR OXT  O N N 418 
TYR H    H N N 419 
TYR H2   H N N 420 
TYR HA   H N N 421 
TYR HB2  H N N 422 
TYR HB3  H N N 423 
TYR HD1  H N N 424 
TYR HD2  H N N 425 
TYR HE1  H N N 426 
TYR HE2  H N N 427 
TYR HH   H N N 428 
TYR HXT  H N N 429 
VAL N    N N N 430 
VAL CA   C N S 431 
VAL C    C N N 432 
VAL O    O N N 433 
VAL CB   C N N 434 
VAL CG1  C N N 435 
VAL CG2  C N N 436 
VAL OXT  O N N 437 
VAL H    H N N 438 
VAL H2   H N N 439 
VAL HA   H N N 440 
VAL HB   H N N 441 
VAL HG11 H N N 442 
VAL HG12 H N N 443 
VAL HG13 H N N 444 
VAL HG21 H N N 445 
VAL HG22 H N N 446 
VAL HG23 H N N 447 
VAL HXT  H N N 448 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
SPH C1  O1   sing N N 290 
SPH C1  C2   sing N N 291 
SPH C1  H11  sing N N 292 
SPH C1  H12  sing N N 293 
SPH O1  HO1  sing N N 294 
SPH C2  N2   sing N N 295 
SPH C2  C3   sing N N 296 
SPH C2  H2   sing N N 297 
SPH N2  HN21 sing N N 298 
SPH N2  HN22 sing N N 299 
SPH C3  O3   sing N N 300 
SPH C3  C4   sing N N 301 
SPH C3  H3   sing N N 302 
SPH O3  HO3  sing N N 303 
SPH C4  C5   doub N Z 304 
SPH C4  H4   sing N N 305 
SPH C5  C6   sing N N 306 
SPH C5  H5   sing N N 307 
SPH C6  C7   sing N N 308 
SPH C6  H61  sing N N 309 
SPH C6  H62  sing N N 310 
SPH C7  C8   sing N N 311 
SPH C7  H71  sing N N 312 
SPH C7  H72  sing N N 313 
SPH C8  C9   sing N N 314 
SPH C8  H81  sing N N 315 
SPH C8  H82  sing N N 316 
SPH C9  C10  sing N N 317 
SPH C9  H91  sing N N 318 
SPH C9  H92  sing N N 319 
SPH C10 C11  sing N N 320 
SPH C10 H101 sing N N 321 
SPH C10 H102 sing N N 322 
SPH C11 C12  sing N N 323 
SPH C11 H111 sing N N 324 
SPH C11 H112 sing N N 325 
SPH C12 C13  sing N N 326 
SPH C12 H121 sing N N 327 
SPH C12 H122 sing N N 328 
SPH C13 C14  sing N N 329 
SPH C13 H131 sing N N 330 
SPH C13 H132 sing N N 331 
SPH C14 C15  sing N N 332 
SPH C14 H141 sing N N 333 
SPH C14 H142 sing N N 334 
SPH C15 C16  sing N N 335 
SPH C15 H151 sing N N 336 
SPH C15 H152 sing N N 337 
SPH C16 C17  sing N N 338 
SPH C16 H161 sing N N 339 
SPH C16 H162 sing N N 340 
SPH C17 C18  sing N N 341 
SPH C17 H171 sing N N 342 
SPH C17 H172 sing N N 343 
SPH C18 H181 sing N N 344 
SPH C18 H182 sing N N 345 
SPH C18 H183 sing N N 346 
THR N   CA   sing N N 347 
THR N   H    sing N N 348 
THR N   H2   sing N N 349 
THR CA  C    sing N N 350 
THR CA  CB   sing N N 351 
THR CA  HA   sing N N 352 
THR C   O    doub N N 353 
THR C   OXT  sing N N 354 
THR CB  OG1  sing N N 355 
THR CB  CG2  sing N N 356 
THR CB  HB   sing N N 357 
THR OG1 HG1  sing N N 358 
THR CG2 HG21 sing N N 359 
THR CG2 HG22 sing N N 360 
THR CG2 HG23 sing N N 361 
THR OXT HXT  sing N N 362 
TRP N   CA   sing N N 363 
TRP N   H    sing N N 364 
TRP N   H2   sing N N 365 
TRP CA  C    sing N N 366 
TRP CA  CB   sing N N 367 
TRP CA  HA   sing N N 368 
TRP C   O    doub N N 369 
TRP C   OXT  sing N N 370 
TRP CB  CG   sing N N 371 
TRP CB  HB2  sing N N 372 
TRP CB  HB3  sing N N 373 
TRP CG  CD1  doub Y N 374 
TRP CG  CD2  sing Y N 375 
TRP CD1 NE1  sing Y N 376 
TRP CD1 HD1  sing N N 377 
TRP CD2 CE2  doub Y N 378 
TRP CD2 CE3  sing Y N 379 
TRP NE1 CE2  sing Y N 380 
TRP NE1 HE1  sing N N 381 
TRP CE2 CZ2  sing Y N 382 
TRP CE3 CZ3  doub Y N 383 
TRP CE3 HE3  sing N N 384 
TRP CZ2 CH2  doub Y N 385 
TRP CZ2 HZ2  sing N N 386 
TRP CZ3 CH2  sing Y N 387 
TRP CZ3 HZ3  sing N N 388 
TRP CH2 HH2  sing N N 389 
TRP OXT HXT  sing N N 390 
TYR N   CA   sing N N 391 
TYR N   H    sing N N 392 
TYR N   H2   sing N N 393 
TYR CA  C    sing N N 394 
TYR CA  CB   sing N N 395 
TYR CA  HA   sing N N 396 
TYR C   O    doub N N 397 
TYR C   OXT  sing N N 398 
TYR CB  CG   sing N N 399 
TYR CB  HB2  sing N N 400 
TYR CB  HB3  sing N N 401 
TYR CG  CD1  doub Y N 402 
TYR CG  CD2  sing Y N 403 
TYR CD1 CE1  sing Y N 404 
TYR CD1 HD1  sing N N 405 
TYR CD2 CE2  doub Y N 406 
TYR CD2 HD2  sing N N 407 
TYR CE1 CZ   doub Y N 408 
TYR CE1 HE1  sing N N 409 
TYR CE2 CZ   sing Y N 410 
TYR CE2 HE2  sing N N 411 
TYR CZ  OH   sing N N 412 
TYR OH  HH   sing N N 413 
TYR OXT HXT  sing N N 414 
VAL N   CA   sing N N 415 
VAL N   H    sing N N 416 
VAL N   H2   sing N N 417 
VAL CA  C    sing N N 418 
VAL CA  CB   sing N N 419 
VAL CA  HA   sing N N 420 
VAL C   O    doub N N 421 
VAL C   OXT  sing N N 422 
VAL CB  CG1  sing N N 423 
VAL CB  CG2  sing N N 424 
VAL CB  HB   sing N N 425 
VAL CG1 HG11 sing N N 426 
VAL CG1 HG12 sing N N 427 
VAL CG1 HG13 sing N N 428 
VAL CG2 HG21 sing N N 429 
VAL CG2 HG22 sing N N 430 
VAL CG2 HG23 sing N N 431 
VAL OXT HXT  sing N N 432 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-10-29 
_em_admin.deposition_site    PDBE 
_em_admin.entry_id           9H94 
_em_admin.last_update        2025-04-09 
_em_admin.map_release_date   2025-04-02 
_em_admin.title              
'Poliovirus type 2 (strain MEF-1) stabilised virus-like particle (PV2 SC5a) from a yeast expression system.' 
# 
loop_
_em_buffer_component.buffer_id 
_em_buffer_component.concentration 
_em_buffer_component.concentration_units 
_em_buffer_component.formula 
_em_buffer_component.id 
_em_buffer_component.name 
1 1  x  ? 1 DPBS 
1 20 mM ? 2 EDTA 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_molwt.entity_assembly_id   1 
_em_entity_assembly_molwt.experimental_flag    NO 
_em_entity_assembly_molwt.id                   1 
_em_entity_assembly_molwt.units                MEGADALTONS 
_em_entity_assembly_molwt.value                5.81 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          12083 
_em_entity_assembly_naturalsource.organism             'Poliovirus 2' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               MEF-1 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          4922 
_em_entity_assembly_recombinant.organism             'Komagataella pastoris' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               3.0 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         47.50 
_em_image_recording.details                             
'Pixel sampling was 0.831 A/pixel. Super-resolution collection mode was used 0.415 A/pixel. Energy filter was Gatan GIF Quantum.' 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 BIOQUANTUM (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    1 
_em_image_recording.num_real_images                     1862 
# 
_em_imaging_optics.chr_aberration_corrector   ? 
_em_imaging_optics.energyfilter_lower         ? 
_em_imaging_optics.energyfilter_slit_width    20 
_em_imaging_optics.energyfilter_name          'GIF Bioquantum' 
_em_imaging_optics.energyfilter_upper         ? 
_em_imaging_optics.id                         1 
_em_imaging_optics.imaging_id                 1 
_em_imaging_optics.phase_plate                ? 
_em_imaging_optics.sph_aberration_corrector   ? 
_em_imaging_optics.details                    ? 
# 
_em_particle_selection.details                  ? 
_em_particle_selection.id                       1 
_em_particle_selection.image_processing_id      1 
_em_particle_selection.method                   ? 
_em_particle_selection.num_particles_selected   243874 
_em_particle_selection.reference_model          ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'            'Template picker'            1  1 ? ? cryoSPARC      4.5.3           
'IMAGE ACQUISITION'             ?                            2  ? ? 1 EPU            ?               
MASKING                         ?                            3  ? ? ? ?              ?               
'CTF CORRECTION'                'Patch CTF'                  4  1 ? ? cryoSPARC      4.5.3           
'LAYERLINE INDEXING'            ?                            5  ? ? ? ?              ?               
'DIFFRACTION INDEXING'          ?                            6  ? ? ? ?              ?               
'MODEL FITTING'                 ?                            7  ? 1 ? 'UCSF Chimera' 1.16            
'MODEL FITTING'                 ?                            8  ? 1 ? Coot           0.9.6           
OTHER                           ?                            9  ? ? ? ?              ?               
'INITIAL EULER ASSIGNMENT'      'ab initio reconstruction'   10 1 ? ? cryoSPARC      4.5.3           
'FINAL EULER ASSIGNMENT'        'Homogeneous reconstruction' 11 1 ? ? cryoSPARC      4.5.3           
CLASSIFICATION                  'Heterogeneous refinement'   12 1 ? ? cryoSPARC      4.5.3           
RECONSTRUCTION                  'Homogeneous reconstruction' 13 1 ? ? cryoSPARC      4.5.3           
'MODEL REFINEMENT'              ?                            14 ? 1 ? PHENIX         1.20.1-4487-000 
'VOLUME SELECTION'              ?                            15 1 1 1 ?              ?               
'SERIES ALIGNMENT'              ?                            16 1 1 1 ?              ?               
'MOLECULAR REPLACEMENT'         ?                            17 1 1 1 ?              ?               
'LATTICE DISTORTION CORRECTION' ?                            18 1 1 1 ?              ?               
'SYMMETRY DETERMINATION'        ?                            19 1 1 1 ?              ?               
'CRYSTALLOGRAPHY MERGING'       ?                            20 1 1 1 ?              ?               
# 
_em_specimen.concentration           0.6 
_em_specimen.details                 'Sample purified by sucrose density gradient ultracentrifugation.' 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_em_virus_natural_host.entity_assembly_id   1 
_em_virus_natural_host.id                   1 
_em_virus_natural_host.ncbi_tax_id          9606 
_em_virus_natural_host.organism             'Homo sapiens' 
_em_virus_natural_host.strain               ? 
# 
_em_virus_shell.diameter             310 
_em_virus_shell.entity_assembly_id   1 
_em_virus_shell.id                   1 
_em_virus_shell.name                 'Virus shell 1' 
_em_virus_shell.triangulation        1 
# 
_pdbx_audit_support.funding_organization   'Bill & Melinda Gates Foundation' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           RG.IMCB.I8-TSA-083 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   1EAH 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9H94 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . GLN A 1 62  ? 189.623 267.916 342.620 1.00 29.77 ? 62  GLN A N   1 
ATOM   2    C CA  . GLN A 1 62  ? 190.059 268.159 341.251 1.00 28.96 ? 62  GLN A CA  1 
ATOM   3    C C   . GLN A 1 62  ? 190.915 269.419 341.171 1.00 31.35 ? 62  GLN A C   1 
ATOM   4    O O   . GLN A 1 62  ? 190.690 270.383 341.904 1.00 33.67 ? 62  GLN A O   1 
ATOM   5    C CB  . GLN A 1 62  ? 188.852 268.274 340.318 1.00 30.10 ? 62  GLN A CB  1 
ATOM   6    C CG  . GLN A 1 62  ? 188.066 266.976 340.174 1.00 28.20 ? 62  GLN A CG  1 
ATOM   7    C CD  . GLN A 1 62  ? 186.826 267.115 339.305 1.00 27.55 ? 62  GLN A CD  1 
ATOM   8    O OE1 . GLN A 1 62  ? 185.827 266.430 339.525 1.00 27.71 ? 62  GLN A OE1 1 
ATOM   9    N NE2 . GLN A 1 62  ? 186.886 267.991 338.308 1.00 31.25 ? 62  GLN A NE2 1 
ATOM   10   N N   . THR A 1 63  ? 191.900 269.402 340.275 1.00 30.02 ? 63  THR A N   1 
ATOM   11   C CA  . THR A 1 63  ? 192.829 270.507 340.104 1.00 31.09 ? 63  THR A CA  1 
ATOM   12   C C   . THR A 1 63  ? 192.871 270.913 338.638 1.00 32.88 ? 63  THR A C   1 
ATOM   13   O O   . THR A 1 63  ? 192.560 270.124 337.742 1.00 35.86 ? 63  THR A O   1 
ATOM   14   C CB  . THR A 1 63  ? 194.246 270.138 340.573 1.00 32.24 ? 63  THR A CB  1 
ATOM   15   O OG1 . THR A 1 63  ? 194.814 269.172 339.679 1.00 34.50 ? 63  THR A OG1 1 
ATOM   16   C CG2 . THR A 1 63  ? 194.214 269.562 341.984 1.00 30.83 ? 63  THR A CG2 1 
ATOM   17   N N   . ARG A 1 64  ? 193.259 272.162 338.403 1.00 33.58 ? 64  ARG A N   1 
ATOM   18   C CA  . ARG A 1 64  ? 193.432 272.685 337.059 1.00 31.53 ? 64  ARG A CA  1 
ATOM   19   C C   . ARG A 1 64  ? 194.895 272.565 336.642 1.00 33.14 ? 64  ARG A C   1 
ATOM   20   O O   . ARG A 1 64  ? 195.751 272.094 337.395 1.00 36.66 ? 64  ARG A O   1 
ATOM   21   C CB  . ARG A 1 64  ? 192.961 274.138 336.980 1.00 30.83 ? 64  ARG A CB  1 
ATOM   22   C CG  . ARG A 1 64  ? 193.717 275.095 337.895 1.00 32.29 ? 64  ARG A CG  1 
ATOM   23   C CD  . ARG A 1 64  ? 193.396 276.547 337.571 1.00 33.15 ? 64  ARG A CD  1 
ATOM   24   N NE  . ARG A 1 64  ? 193.772 276.900 336.207 1.00 34.73 ? 64  ARG A NE  1 
ATOM   25   C CZ  . ARG A 1 64  ? 193.369 277.993 335.574 1.00 32.16 ? 64  ARG A CZ  1 
ATOM   26   N NH1 . ARG A 1 64  ? 192.562 278.869 336.150 1.00 31.16 ? 64  ARG A NH1 1 
ATOM   27   N NH2 . ARG A 1 64  ? 193.783 278.212 334.329 1.00 35.02 ? 64  ARG A NH2 1 
ATOM   28   N N   . HIS A 1 65  ? 195.182 273.002 335.421 1.00 36.51 ? 65  HIS A N   1 
ATOM   29   C CA  . HIS A 1 65  ? 196.546 273.040 334.915 1.00 35.68 ? 65  HIS A CA  1 
ATOM   30   C C   . HIS A 1 65  ? 197.152 274.400 335.234 1.00 35.94 ? 65  HIS A C   1 
ATOM   31   O O   . HIS A 1 65  ? 196.620 275.436 334.821 1.00 37.87 ? 65  HIS A O   1 
ATOM   32   C CB  . HIS A 1 65  ? 196.580 272.776 333.411 1.00 34.94 ? 65  HIS A CB  1 
ATOM   33   C CG  . HIS A 1 65  ? 197.927 272.987 332.793 1.00 37.09 ? 65  HIS A CG  1 
ATOM   34   N ND1 . HIS A 1 65  ? 198.141 273.866 331.754 1.00 39.21 ? 65  HIS A ND1 1 
ATOM   35   C CD2 . HIS A 1 65  ? 199.132 272.436 333.073 1.00 36.40 ? 65  HIS A CD2 1 
ATOM   36   C CE1 . HIS A 1 65  ? 199.417 273.845 331.417 1.00 38.17 ? 65  HIS A CE1 1 
ATOM   37   N NE2 . HIS A 1 65  ? 200.041 272.986 332.203 1.00 36.56 ? 65  HIS A NE2 1 
ATOM   38   N N   . VAL A 1 66  ? 198.258 274.395 335.971 1.00 35.15 ? 66  VAL A N   1 
ATOM   39   C CA  . VAL A 1 66  ? 198.976 275.610 336.333 1.00 36.15 ? 66  VAL A CA  1 
ATOM   40   C C   . VAL A 1 66  ? 200.414 275.454 335.862 1.00 36.81 ? 66  VAL A C   1 
ATOM   41   O O   . VAL A 1 66  ? 201.089 274.481 336.223 1.00 35.20 ? 66  VAL A O   1 
ATOM   42   C CB  . VAL A 1 66  ? 198.918 275.880 337.845 1.00 34.29 ? 66  VAL A CB  1 
ATOM   43   C CG1 . VAL A 1 66  ? 199.636 277.178 338.181 1.00 33.06 ? 66  VAL A CG1 1 
ATOM   44   C CG2 . VAL A 1 66  ? 197.473 275.923 338.326 1.00 34.11 ? 66  VAL A CG2 1 
ATOM   45   N N   . ILE A 1 67  ? 200.879 276.405 335.054 1.00 36.62 ? 67  ILE A N   1 
ATOM   46   C CA  . ILE A 1 67  ? 202.269 276.429 334.615 1.00 36.67 ? 67  ILE A CA  1 
ATOM   47   C C   . ILE A 1 67  ? 203.082 277.100 335.712 1.00 36.78 ? 67  ILE A C   1 
ATOM   48   O O   . ILE A 1 67  ? 203.275 278.321 335.701 1.00 36.97 ? 67  ILE A O   1 
ATOM   49   C CB  . ILE A 1 67  ? 202.427 277.161 333.269 1.00 37.26 ? 67  ILE A CB  1 
ATOM   50   C CG1 . ILE A 1 67  ? 201.580 276.477 332.191 1.00 36.94 ? 67  ILE A CG1 1 
ATOM   51   C CG2 . ILE A 1 67  ? 203.894 277.203 332.855 1.00 33.54 ? 67  ILE A CG2 1 
ATOM   52   C CD1 . ILE A 1 67  ? 201.539 277.220 330.869 1.00 36.62 ? 67  ILE A CD1 1 
ATOM   53   N N   . GLN A 1 68  ? 203.557 276.307 336.668 1.00 38.07 ? 68  GLN A N   1 
ATOM   54   C CA  . GLN A 1 68  ? 204.242 276.865 337.823 1.00 34.06 ? 68  GLN A CA  1 
ATOM   55   C C   . GLN A 1 68  ? 205.561 277.503 337.409 1.00 32.57 ? 68  GLN A C   1 
ATOM   56   O O   . GLN A 1 68  ? 206.313 276.953 336.600 1.00 36.10 ? 68  GLN A O   1 
ATOM   57   C CB  . GLN A 1 68  ? 204.490 275.779 338.870 1.00 32.86 ? 68  GLN A CB  1 
ATOM   58   C CG  . GLN A 1 68  ? 204.953 276.320 340.217 1.00 30.22 ? 68  GLN A CG  1 
ATOM   59   C CD  . GLN A 1 68  ? 203.927 277.232 340.860 1.00 35.03 ? 68  GLN A CD  1 
ATOM   60   O OE1 . GLN A 1 68  ? 204.196 278.406 341.116 1.00 34.47 ? 68  GLN A OE1 1 
ATOM   61   N NE2 . GLN A 1 68  ? 202.741 276.694 341.125 1.00 32.18 ? 68  GLN A NE2 1 
ATOM   62   N N   . LYS A 1 69  ? 205.836 278.678 337.973 1.00 31.87 ? 69  LYS A N   1 
ATOM   63   C CA  . LYS A 1 69  ? 207.051 279.419 337.683 1.00 28.69 ? 69  LYS A CA  1 
ATOM   64   C C   . LYS A 1 69  ? 207.936 279.625 338.903 1.00 28.73 ? 69  LYS A C   1 
ATOM   65   O O   . LYS A 1 69  ? 209.094 280.025 338.741 1.00 33.21 ? 69  LYS A O   1 
ATOM   66   C CB  . LYS A 1 69  ? 206.706 280.793 337.085 1.00 28.93 ? 69  LYS A CB  1 
ATOM   67   C CG  . LYS A 1 69  ? 205.889 280.731 335.802 1.00 28.19 ? 69  LYS A CG  1 
ATOM   68   C CD  . LYS A 1 69  ? 205.367 282.107 335.419 1.00 29.51 ? 69  LYS A CD  1 
ATOM   69   C CE  . LYS A 1 69  ? 204.621 282.086 334.099 1.00 32.96 ? 69  LYS A CE  1 
ATOM   70   N NZ  . LYS A 1 69  ? 204.180 283.449 333.695 1.00 31.96 ? 69  LYS A NZ  1 
ATOM   71   N N   . ARG A 1 70  ? 207.434 279.359 340.107 1.00 25.74 ? 70  ARG A N   1 
ATOM   72   C CA  . ARG A 1 70  ? 208.204 279.612 341.316 1.00 24.58 ? 70  ARG A CA  1 
ATOM   73   C C   . ARG A 1 70  ? 209.402 278.675 341.392 1.00 18.34 ? 70  ARG A C   1 
ATOM   74   O O   . ARG A 1 70  ? 209.287 277.477 341.120 1.00 26.58 ? 70  ARG A O   1 
ATOM   75   C CB  . ARG A 1 70  ? 207.318 279.444 342.550 1.00 23.81 ? 70  ARG A CB  1 
ATOM   76   C CG  . ARG A 1 70  ? 206.254 280.519 342.684 1.00 20.81 ? 70  ARG A CG  1 
ATOM   77   C CD  . ARG A 1 70  ? 205.442 280.375 343.961 1.00 17.05 ? 70  ARG A CD  1 
ATOM   78   N NE  . ARG A 1 70  ? 204.489 279.272 343.900 1.00 22.11 ? 70  ARG A NE  1 
ATOM   79   C CZ  . ARG A 1 70  ? 204.710 278.050 344.365 1.00 18.59 ? 70  ARG A CZ  1 
ATOM   80   N NH1 . ARG A 1 70  ? 205.860 277.719 344.930 1.00 21.27 ? 70  ARG A NH1 1 
ATOM   81   N NH2 . ARG A 1 70  ? 203.751 277.135 344.261 1.00 21.06 ? 70  ARG A NH2 1 
ATOM   82   N N   . THR A 1 71  ? 210.554 279.227 341.757 1.00 18.58 ? 71  THR A N   1 
ATOM   83   C CA  . THR A 1 71  ? 211.784 278.473 341.943 1.00 16.17 ? 71  THR A CA  1 
ATOM   84   C C   . THR A 1 71  ? 212.191 278.509 343.411 1.00 16.19 ? 71  THR A C   1 
ATOM   85   O O   . THR A 1 71  ? 211.650 279.271 344.217 1.00 18.46 ? 71  THR A O   1 
ATOM   86   C CB  . THR A 1 71  ? 212.916 279.034 341.073 1.00 18.53 ? 71  THR A CB  1 
ATOM   87   O OG1 . THR A 1 71  ? 213.453 280.214 341.684 1.00 24.68 ? 71  THR A OG1 1 
ATOM   88   C CG2 . THR A 1 71  ? 212.411 279.376 339.678 1.00 20.60 ? 71  THR A CG2 1 
ATOM   89   N N   . ARG A 1 72  ? 213.169 277.675 343.748 1.00 13.78 ? 72  ARG A N   1 
ATOM   90   C CA  . ARG A 1 72  ? 213.695 277.567 345.104 1.00 9.58  ? 72  ARG A CA  1 
ATOM   91   C C   . ARG A 1 72  ? 215.095 278.164 345.197 1.00 9.04  ? 72  ARG A C   1 
ATOM   92   O O   . ARG A 1 72  ? 215.953 277.674 345.932 1.00 16.23 ? 72  ARG A O   1 
ATOM   93   C CB  . ARG A 1 72  ? 213.695 276.110 345.561 1.00 6.94  ? 72  ARG A CB  1 
ATOM   94   C CG  . ARG A 1 72  ? 212.303 275.533 345.727 1.00 10.84 ? 72  ARG A CG  1 
ATOM   95   C CD  . ARG A 1 72  ? 212.334 274.053 346.055 1.00 7.91  ? 72  ARG A CD  1 
ATOM   96   N NE  . ARG A 1 72  ? 211.025 273.574 346.479 1.00 13.38 ? 72  ARG A NE  1 
ATOM   97   C CZ  . ARG A 1 72  ? 210.767 272.333 346.868 1.00 8.20  ? 72  ARG A CZ  1 
ATOM   98   N NH1 . ARG A 1 72  ? 211.709 271.405 346.890 1.00 10.52 ? 72  ARG A NH1 1 
ATOM   99   N NH2 . ARG A 1 72  ? 209.532 272.016 347.242 1.00 11.98 ? 72  ARG A NH2 1 
ATOM   100  N N   . SER A 1 73  ? 215.331 279.242 344.447 1.00 11.50 ? 73  SER A N   1 
ATOM   101  C CA  . SER A 1 73  ? 216.668 279.822 344.371 1.00 6.97  ? 73  SER A CA  1 
ATOM   102  C C   . SER A 1 73  ? 217.128 280.349 345.725 1.00 5.42  ? 73  SER A C   1 
ATOM   103  O O   . SER A 1 73  ? 218.293 280.181 346.100 1.00 13.66 ? 73  SER A O   1 
ATOM   104  C CB  . SER A 1 73  ? 216.696 280.937 343.324 1.00 8.85  ? 73  SER A CB  1 
ATOM   105  O OG  . SER A 1 73  ? 215.799 281.982 343.656 1.00 24.63 ? 73  SER A OG  1 
ATOM   106  N N   . GLU A 1 74  ? 216.236 280.990 346.473 1.00 8.26  ? 74  GLU A N   1 
ATOM   107  C CA  . GLU A 1 74  ? 216.628 281.605 347.733 1.00 9.95  ? 74  GLU A CA  1 
ATOM   108  C C   . GLU A 1 74  ? 216.632 280.625 348.900 1.00 8.46  ? 74  GLU A C   1 
ATOM   109  O O   . GLU A 1 74  ? 217.001 281.019 350.010 1.00 11.11 ? 74  GLU A O   1 
ATOM   110  C CB  . GLU A 1 74  ? 215.709 282.786 348.055 1.00 13.22 ? 74  GLU A CB  1 
ATOM   111  C CG  . GLU A 1 74  ? 216.332 283.793 349.013 1.00 15.23 ? 74  GLU A CG  1 
ATOM   112  C CD  . GLU A 1 74  ? 215.476 285.026 349.223 1.00 14.16 ? 74  GLU A CD  1 
ATOM   113  O OE1 . GLU A 1 74  ? 214.483 285.201 348.489 1.00 13.97 ? 74  GLU A OE1 1 
ATOM   114  O OE2 . GLU A 1 74  ? 215.800 285.821 350.128 1.00 22.20 ? 74  GLU A OE2 1 
ATOM   115  N N   . SER A 1 75  ? 216.241 279.371 348.684 1.00 9.07  ? 75  SER A N   1 
ATOM   116  C CA  . SER A 1 75  ? 216.295 278.351 349.723 1.00 7.89  ? 75  SER A CA  1 
ATOM   117  C C   . SER A 1 75  ? 217.418 277.344 349.503 1.00 5.48  ? 75  SER A C   1 
ATOM   118  O O   . SER A 1 75  ? 217.494 276.353 350.233 1.00 11.99 ? 75  SER A O   1 
ATOM   119  C CB  . SER A 1 75  ? 214.952 277.626 349.829 1.00 5.39  ? 75  SER A CB  1 
ATOM   120  O OG  . SER A 1 75  ? 214.566 277.068 348.591 1.00 13.75 ? 75  SER A OG  1 
ATOM   121  N N   . THR A 1 76  ? 218.288 277.568 348.522 1.00 1.92  ? 76  THR A N   1 
ATOM   122  C CA  . THR A 1 76  ? 219.489 276.752 348.414 1.00 8.19  ? 76  THR A CA  1 
ATOM   123  C C   . THR A 1 76  ? 220.354 276.966 349.649 1.00 1.79  ? 76  THR A C   1 
ATOM   124  O O   . THR A 1 76  ? 220.321 278.026 350.277 1.00 7.51  ? 76  THR A O   1 
ATOM   125  C CB  . THR A 1 76  ? 220.285 277.104 347.152 1.00 5.28  ? 76  THR A CB  1 
ATOM   126  O OG1 . THR A 1 76  ? 220.842 278.417 347.283 1.00 14.85 ? 76  THR A OG1 1 
ATOM   127  C CG2 . THR A 1 76  ? 219.401 277.052 345.913 1.00 3.99  ? 76  THR A CG2 1 
ATOM   128  N N   . VAL A 1 77  ? 221.122 275.937 350.013 1.00 9.87  ? 77  VAL A N   1 
ATOM   129  C CA  . VAL A 1 77  ? 221.966 276.053 351.199 1.00 8.62  ? 77  VAL A CA  1 
ATOM   130  C C   . VAL A 1 77  ? 222.934 277.218 351.052 1.00 5.79  ? 77  VAL A C   1 
ATOM   131  O O   . VAL A 1 77  ? 223.261 277.890 352.036 1.00 5.59  ? 77  VAL A O   1 
ATOM   132  C CB  . VAL A 1 77  ? 222.705 274.727 351.480 1.00 7.89  ? 77  VAL A CB  1 
ATOM   133  C CG1 . VAL A 1 77  ? 221.711 273.642 351.880 1.00 7.93  ? 77  VAL A CG1 1 
ATOM   134  C CG2 . VAL A 1 77  ? 223.531 274.289 350.276 1.00 14.59 ? 77  VAL A CG2 1 
ATOM   135  N N   . GLU A 1 78  ? 223.394 277.491 349.830 1.00 9.07  ? 78  GLU A N   1 
ATOM   136  C CA  . GLU A 1 78  ? 224.230 278.668 349.614 1.00 7.34  ? 78  GLU A CA  1 
ATOM   137  C C   . GLU A 1 78  ? 223.485 279.937 350.012 1.00 12.01 ? 78  GLU A C   1 
ATOM   138  O O   . GLU A 1 78  ? 223.984 280.738 350.810 1.00 10.54 ? 78  GLU A O   1 
ATOM   139  C CB  . GLU A 1 78  ? 224.676 278.735 348.151 1.00 11.85 ? 78  GLU A CB  1 
ATOM   140  C CG  . GLU A 1 78  ? 225.759 279.770 347.870 1.00 9.55  ? 78  GLU A CG  1 
ATOM   141  C CD  . GLU A 1 78  ? 227.091 279.424 348.516 1.00 16.84 ? 78  GLU A CD  1 
ATOM   142  O OE1 . GLU A 1 78  ? 227.221 278.309 349.061 1.00 22.62 ? 78  GLU A OE1 1 
ATOM   143  O OE2 . GLU A 1 78  ? 228.009 280.267 348.477 1.00 24.87 ? 78  GLU A OE2 1 
ATOM   144  N N   . SER A 1 79  ? 222.271 280.121 349.485 1.00 3.29  ? 79  SER A N   1 
ATOM   145  C CA  . SER A 1 79  ? 221.502 281.327 349.785 1.00 6.92  ? 79  SER A CA  1 
ATOM   146  C C   . SER A 1 79  ? 221.136 281.404 351.262 1.00 5.33  ? 79  SER A C   1 
ATOM   147  O O   . SER A 1 79  ? 221.169 282.484 351.861 1.00 10.30 ? 79  SER A O   1 
ATOM   148  C CB  . SER A 1 79  ? 220.238 281.370 348.925 1.00 7.85  ? 79  SER A CB  1 
ATOM   149  O OG  . SER A 1 79  ? 220.559 281.371 347.548 1.00 14.83 ? 79  SER A OG  1 
ATOM   150  N N   . PHE A 1 80  ? 220.780 280.270 351.866 1.00 3.59  ? 80  PHE A N   1 
ATOM   151  C CA  . PHE A 1 80  ? 220.385 280.274 353.270 1.00 6.24  ? 80  PHE A CA  1 
ATOM   152  C C   . PHE A 1 80  ? 221.508 280.780 354.168 1.00 4.95  ? 80  PHE A C   1 
ATOM   153  O O   . PHE A 1 80  ? 221.239 281.387 355.209 1.00 10.91 ? 80  PHE A O   1 
ATOM   154  C CB  . PHE A 1 80  ? 219.950 278.869 353.689 1.00 4.54  ? 80  PHE A CB  1 
ATOM   155  C CG  . PHE A 1 80  ? 219.394 278.792 355.082 1.00 5.46  ? 80  PHE A CG  1 
ATOM   156  C CD1 . PHE A 1 80  ? 218.175 279.375 355.390 1.00 8.12  ? 80  PHE A CD1 1 
ATOM   157  C CD2 . PHE A 1 80  ? 220.083 278.125 356.082 1.00 3.93  ? 80  PHE A CD2 1 
ATOM   158  C CE1 . PHE A 1 80  ? 217.659 279.302 356.669 1.00 4.90  ? 80  PHE A CE1 1 
ATOM   159  C CE2 . PHE A 1 80  ? 219.573 278.050 357.365 1.00 5.81  ? 80  PHE A CE2 1 
ATOM   160  C CZ  . PHE A 1 80  ? 218.360 278.638 357.659 1.00 6.45  ? 80  PHE A CZ  1 
ATOM   161  N N   . PHE A 1 81  ? 222.764 280.552 353.784 1.00 5.09  ? 81  PHE A N   1 
ATOM   162  C CA  . PHE A 1 81  ? 223.914 280.999 354.561 1.00 6.15  ? 81  PHE A CA  1 
ATOM   163  C C   . PHE A 1 81  ? 224.638 282.184 353.928 1.00 9.61  ? 81  PHE A C   1 
ATOM   164  O O   . PHE A 1 81  ? 225.703 282.574 354.415 1.00 17.22 ? 81  PHE A O   1 
ATOM   165  C CB  . PHE A 1 81  ? 224.891 279.838 354.765 1.00 5.03  ? 81  PHE A CB  1 
ATOM   166  C CG  . PHE A 1 81  ? 224.359 278.746 355.652 1.00 6.79  ? 81  PHE A CG  1 
ATOM   167  C CD1 . PHE A 1 81  ? 224.336 278.904 357.026 1.00 9.73  ? 81  PHE A CD1 1 
ATOM   168  C CD2 . PHE A 1 81  ? 223.888 277.562 355.113 1.00 3.80  ? 81  PHE A CD2 1 
ATOM   169  C CE1 . PHE A 1 81  ? 223.850 277.904 357.844 1.00 8.07  ? 81  PHE A CE1 1 
ATOM   170  C CE2 . PHE A 1 81  ? 223.400 276.556 355.930 1.00 9.75  ? 81  PHE A CE2 1 
ATOM   171  C CZ  . PHE A 1 81  ? 223.381 276.730 357.295 1.00 4.09  ? 81  PHE A CZ  1 
ATOM   172  N N   . ALA A 1 82  ? 224.085 282.777 352.869 1.00 4.01  ? 82  ALA A N   1 
ATOM   173  C CA  . ALA A 1 82  ? 224.767 283.846 352.147 1.00 14.23 ? 82  ALA A CA  1 
ATOM   174  C C   . ALA A 1 82  ? 224.587 285.190 352.844 1.00 8.33  ? 82  ALA A C   1 
ATOM   175  O O   . ALA A 1 82  ? 224.138 286.161 352.228 1.00 21.21 ? 82  ALA A O   1 
ATOM   176  C CB  . ALA A 1 82  ? 224.254 283.926 350.708 1.00 7.11  ? 82  ALA A CB  1 
ATOM   177  N N   . ARG A 1 83  ? 224.934 285.253 354.126 1.00 5.35  ? 83  ARG A N   1 
ATOM   178  C CA  . ARG A 1 83  ? 224.803 286.471 354.909 1.00 6.45  ? 83  ARG A CA  1 
ATOM   179  C C   . ARG A 1 83  ? 225.954 286.545 355.898 1.00 15.36 ? 83  ARG A C   1 
ATOM   180  O O   . ARG A 1 83  ? 226.402 285.520 356.417 1.00 15.73 ? 83  ARG A O   1 
ATOM   181  C CB  . ARG A 1 83  ? 223.473 286.517 355.670 1.00 10.83 ? 83  ARG A CB  1 
ATOM   182  C CG  . ARG A 1 83  ? 222.234 286.565 354.801 1.00 15.68 ? 83  ARG A CG  1 
ATOM   183  C CD  . ARG A 1 83  ? 222.062 287.914 354.126 1.00 11.22 ? 83  ARG A CD  1 
ATOM   184  N NE  . ARG A 1 83  ? 220.751 288.029 353.500 1.00 8.43  ? 83  ARG A NE  1 
ATOM   185  C CZ  . ARG A 1 83  ? 220.458 287.606 352.278 1.00 8.63  ? 83  ARG A CZ  1 
ATOM   186  N NH1 . ARG A 1 83  ? 221.373 287.063 351.493 1.00 14.01 ? 83  ARG A NH1 1 
ATOM   187  N NH2 . ARG A 1 83  ? 219.212 287.731 351.832 1.00 12.94 ? 83  ARG A NH2 1 
ATOM   188  N N   . GLY A 1 84  ? 226.427 287.760 356.151 1.00 11.96 ? 84  GLY A N   1 
ATOM   189  C CA  . GLY A 1 84  ? 227.365 287.979 357.230 1.00 9.79  ? 84  GLY A CA  1 
ATOM   190  C C   . GLY A 1 84  ? 226.645 288.026 358.560 1.00 8.41  ? 84  GLY A C   1 
ATOM   191  O O   . GLY A 1 84  ? 225.718 288.821 358.737 1.00 19.03 ? 84  GLY A O   1 
ATOM   192  N N   . ALA A 1 85  ? 227.052 287.180 359.500 1.00 8.99  ? 85  ALA A N   1 
ATOM   193  C CA  . ALA A 1 85  ? 226.428 287.095 360.813 1.00 7.91  ? 85  ALA A CA  1 
ATOM   194  C C   . ALA A 1 85  ? 227.454 287.438 361.880 1.00 5.16  ? 85  ALA A C   1 
ATOM   195  O O   . ALA A 1 85  ? 228.588 286.952 361.834 1.00 13.54 ? 85  ALA A O   1 
ATOM   196  C CB  . ALA A 1 85  ? 225.852 285.698 361.059 1.00 9.15  ? 85  ALA A CB  1 
ATOM   197  N N   . CYS A 1 86  ? 227.058 288.272 362.836 1.00 10.40 ? 86  CYS A N   1 
ATOM   198  C CA  . CYS A 1 86  ? 227.956 288.656 363.915 1.00 7.45  ? 86  CYS A CA  1 
ATOM   199  C C   . CYS A 1 86  ? 228.243 287.449 364.797 1.00 8.98  ? 86  CYS A C   1 
ATOM   200  O O   . CYS A 1 86  ? 227.320 286.849 365.355 1.00 23.80 ? 86  CYS A O   1 
ATOM   201  C CB  . CYS A 1 86  ? 227.346 289.783 364.741 1.00 7.97  ? 86  CYS A CB  1 
ATOM   202  S SG  . CYS A 1 86  ? 228.473 290.499 365.958 1.00 23.24 ? 86  CYS A SG  1 
ATOM   203  N N   . VAL A 1 87  ? 229.519 287.096 364.927 1.00 13.82 ? 87  VAL A N   1 
ATOM   204  C CA  . VAL A 1 87  ? 229.928 285.974 365.765 1.00 9.85  ? 87  VAL A CA  1 
ATOM   205  C C   . VAL A 1 87  ? 230.740 286.406 366.972 1.00 6.32  ? 87  VAL A C   1 
ATOM   206  O O   . VAL A 1 87  ? 231.038 285.557 367.827 1.00 18.85 ? 87  VAL A O   1 
ATOM   207  C CB  . VAL A 1 87  ? 230.716 284.919 364.959 1.00 10.64 ? 87  VAL A CB  1 
ATOM   208  C CG1 . VAL A 1 87  ? 229.841 284.323 363.868 1.00 13.15 ? 87  VAL A CG1 1 
ATOM   209  C CG2 . VAL A 1 87  ? 231.988 285.520 364.370 1.00 6.81  ? 87  VAL A CG2 1 
ATOM   210  N N   . ALA A 1 88  ? 231.109 287.680 367.082 1.00 4.96  ? 88  ALA A N   1 
ATOM   211  C CA  . ALA A 1 88  ? 231.907 288.106 368.223 1.00 8.43  ? 88  ALA A CA  1 
ATOM   212  C C   . ALA A 1 88  ? 232.024 289.620 368.250 1.00 8.17  ? 88  ALA A C   1 
ATOM   213  O O   . ALA A 1 88  ? 232.014 290.280 367.207 1.00 10.89 ? 88  ALA A O   1 
ATOM   214  C CB  . ALA A 1 88  ? 233.304 287.480 368.190 1.00 6.35  ? 88  ALA A CB  1 
ATOM   215  N N   . ILE A 1 89  ? 232.156 290.149 369.463 1.00 8.28  ? 89  ILE A N   1 
ATOM   216  C CA  . ILE A 1 89  ? 232.400 291.564 369.711 1.00 9.36  ? 89  ILE A CA  1 
ATOM   217  C C   . ILE A 1 89  ? 233.635 291.619 370.604 1.00 14.48 ? 89  ILE A C   1 
ATOM   218  O O   . ILE A 1 89  ? 233.555 291.330 371.802 1.00 17.52 ? 89  ILE A O   1 
ATOM   219  C CB  . ILE A 1 89  ? 231.204 292.259 370.372 1.00 9.48  ? 89  ILE A CB  1 
ATOM   220  C CG1 . ILE A 1 89  ? 229.921 291.968 369.586 1.00 15.95 ? 89  ILE A CG1 1 
ATOM   221  C CG2 . ILE A 1 89  ? 231.451 293.758 370.472 1.00 13.14 ? 89  ILE A CG2 1 
ATOM   222  C CD1 . ILE A 1 89  ? 228.674 292.576 370.186 1.00 14.70 ? 89  ILE A CD1 1 
ATOM   223  N N   . ILE A 1 90  ? 234.774 291.989 370.030 1.00 13.45 ? 90  ILE A N   1 
ATOM   224  C CA  . ILE A 1 90  ? 236.055 291.973 370.724 1.00 14.79 ? 90  ILE A CA  1 
ATOM   225  C C   . ILE A 1 90  ? 236.376 293.396 371.152 1.00 9.02  ? 90  ILE A C   1 
ATOM   226  O O   . ILE A 1 90  ? 236.517 294.288 370.310 1.00 16.65 ? 90  ILE A O   1 
ATOM   227  C CB  . ILE A 1 90  ? 237.167 291.404 369.828 1.00 8.07  ? 90  ILE A CB  1 
ATOM   228  C CG1 . ILE A 1 90  ? 236.771 290.023 369.300 1.00 10.54 ? 90  ILE A CG1 1 
ATOM   229  C CG2 . ILE A 1 90  ? 238.479 291.332 370.594 1.00 13.17 ? 90  ILE A CG2 1 
ATOM   230  C CD1 . ILE A 1 90  ? 237.685 289.500 368.225 1.00 12.52 ? 90  ILE A CD1 1 
ATOM   231  N N   . GLU A 1 91  ? 236.506 293.613 372.454 1.00 11.31 ? 91  GLU A N   1 
ATOM   232  C CA  . GLU A 1 91  ? 236.736 294.942 372.999 1.00 14.86 ? 91  GLU A CA  1 
ATOM   233  C C   . GLU A 1 91  ? 238.218 295.129 373.290 1.00 11.99 ? 91  GLU A C   1 
ATOM   234  O O   . GLU A 1 91  ? 238.847 294.269 373.915 1.00 25.38 ? 91  GLU A O   1 
ATOM   235  C CB  . GLU A 1 91  ? 235.912 295.157 374.268 1.00 14.04 ? 91  GLU A CB  1 
ATOM   236  C CG  . GLU A 1 91  ? 235.970 296.577 374.804 1.00 21.12 ? 91  GLU A CG  1 
ATOM   237  C CD  . GLU A 1 91  ? 234.945 296.832 375.889 1.00 21.73 ? 91  GLU A CD  1 
ATOM   238  O OE1 . GLU A 1 91  ? 234.150 295.916 376.184 1.00 24.44 ? 91  GLU A OE1 1 
ATOM   239  O OE2 . GLU A 1 91  ? 234.933 297.949 376.446 1.00 24.92 ? 91  GLU A OE2 1 
ATOM   240  N N   . VAL A 1 92  ? 238.775 296.246 372.822 1.00 13.56 ? 92  VAL A N   1 
ATOM   241  C CA  . VAL A 1 92  ? 240.153 296.614 373.110 1.00 13.75 ? 92  VAL A CA  1 
ATOM   242  C C   . VAL A 1 92  ? 240.187 298.077 373.526 1.00 10.73 ? 92  VAL A C   1 
ATOM   243  O O   . VAL A 1 92  ? 239.247 298.839 373.291 1.00 20.55 ? 92  VAL A O   1 
ATOM   244  C CB  . VAL A 1 92  ? 241.098 296.372 371.912 1.00 11.66 ? 92  VAL A CB  1 
ATOM   245  C CG1 . VAL A 1 92  ? 241.205 294.887 371.612 1.00 18.28 ? 92  VAL A CG1 1 
ATOM   246  C CG2 . VAL A 1 92  ? 240.625 297.137 370.688 1.00 13.48 ? 92  VAL A CG2 1 
ATOM   247  N N   . ASP A 1 93  ? 241.283 298.459 374.170 1.00 16.83 ? 93  ASP A N   1 
ATOM   248  C CA  . ASP A 1 93  ? 241.470 299.817 374.651 1.00 17.86 ? 93  ASP A CA  1 
ATOM   249  C C   . ASP A 1 93  ? 242.815 300.351 374.191 1.00 20.16 ? 93  ASP A C   1 
ATOM   250  O O   . ASP A 1 93  ? 243.824 299.641 374.230 1.00 25.12 ? 93  ASP A O   1 
ATOM   251  C CB  . ASP A 1 93  ? 241.394 299.884 376.177 1.00 19.76 ? 93  ASP A CB  1 
ATOM   252  C CG  . ASP A 1 93  ? 240.041 299.473 376.712 1.00 26.66 ? 93  ASP A CG  1 
ATOM   253  O OD1 . ASP A 1 93  ? 239.032 299.685 376.009 1.00 28.11 ? 93  ASP A OD1 1 
ATOM   254  O OD2 . ASP A 1 93  ? 239.987 298.935 377.837 1.00 30.05 ? 93  ASP A OD2 1 
ATOM   255  N N   . ASN A 1 94  ? 242.818 301.601 373.746 1.00 22.61 ? 94  ASN A N   1 
ATOM   256  C CA  . ASN A 1 94  ? 244.040 302.365 373.544 1.00 20.69 ? 94  ASN A CA  1 
ATOM   257  C C   . ASN A 1 94  ? 244.180 303.295 374.743 1.00 16.69 ? 94  ASN A C   1 
ATOM   258  O O   . ASN A 1 94  ? 243.399 304.238 374.902 1.00 22.23 ? 94  ASN A O   1 
ATOM   259  C CB  . ASN A 1 94  ? 243.999 303.143 372.232 1.00 18.37 ? 94  ASN A CB  1 
ATOM   260  C CG  . ASN A 1 94  ? 245.205 304.039 372.052 1.00 20.89 ? 94  ASN A CG  1 
ATOM   261  O OD1 . ASN A 1 94  ? 246.265 303.592 371.623 1.00 26.96 ? 94  ASN A OD1 1 
ATOM   262  N ND2 . ASN A 1 94  ? 245.048 305.314 372.383 1.00 29.20 ? 94  ASN A ND2 1 
ATOM   263  N N   . ASP A 1 95  ? 245.165 303.016 375.589 1.00 24.61 ? 95  ASP A N   1 
ATOM   264  C CA  . ASP A 1 95  ? 245.308 303.718 376.855 1.00 26.93 ? 95  ASP A CA  1 
ATOM   265  C C   . ASP A 1 95  ? 246.731 303.521 377.355 1.00 26.21 ? 95  ASP A C   1 
ATOM   266  O O   . ASP A 1 95  ? 247.491 302.712 376.820 1.00 25.02 ? 95  ASP A O   1 
ATOM   267  C CB  . ASP A 1 95  ? 244.285 303.211 377.877 1.00 25.99 ? 95  ASP A CB  1 
ATOM   268  C CG  . ASP A 1 95  ? 244.079 304.173 379.026 1.00 32.00 ? 95  ASP A CG  1 
ATOM   269  O OD1 . ASP A 1 95  ? 244.783 305.204 379.081 1.00 32.31 ? 95  ASP A OD1 1 
ATOM   270  O OD2 . ASP A 1 95  ? 243.210 303.897 379.877 1.00 33.35 ? 95  ASP A OD2 1 
ATOM   271  N N   . ALA A 1 96  ? 247.083 304.277 378.389 1.00 30.11 ? 96  ALA A N   1 
ATOM   272  C CA  . ALA A 1 96  ? 248.396 304.125 378.994 1.00 27.59 ? 96  ALA A CA  1 
ATOM   273  C C   . ALA A 1 96  ? 248.539 302.713 379.562 1.00 31.55 ? 96  ALA A C   1 
ATOM   274  O O   . ALA A 1 96  ? 247.591 302.186 380.156 1.00 33.57 ? 96  ALA A O   1 
ATOM   275  C CB  . ALA A 1 96  ? 248.602 305.162 380.098 1.00 30.46 ? 96  ALA A CB  1 
ATOM   276  N N   . PRO A 1 97  ? 249.698 302.068 379.400 1.00 30.31 ? 97  PRO A N   1 
ATOM   277  C CA  . PRO A 1 97  ? 249.831 300.680 379.877 1.00 31.30 ? 97  PRO A CA  1 
ATOM   278  C C   . PRO A 1 97  ? 249.665 300.516 381.379 1.00 33.64 ? 97  PRO A C   1 
ATOM   279  O O   . PRO A 1 97  ? 249.377 299.402 381.830 1.00 37.83 ? 97  PRO A O   1 
ATOM   280  C CB  . PRO A 1 97  ? 251.246 300.288 379.431 1.00 32.36 ? 97  PRO A CB  1 
ATOM   281  C CG  . PRO A 1 97  ? 251.580 301.221 378.330 1.00 32.47 ? 97  PRO A CG  1 
ATOM   282  C CD  . PRO A 1 97  ? 250.897 302.507 378.664 1.00 31.07 ? 97  PRO A CD  1 
ATOM   283  N N   . THR A 1 98  ? 249.830 301.575 382.167 1.00 36.10 ? 98  THR A N   1 
ATOM   284  C CA  . THR A 1 98  ? 249.849 301.466 383.620 1.00 37.57 ? 98  THR A CA  1 
ATOM   285  C C   . THR A 1 98  ? 248.472 301.631 384.254 1.00 38.02 ? 98  THR A C   1 
ATOM   286  O O   . THR A 1 98  ? 248.370 301.648 385.483 1.00 40.72 ? 98  THR A O   1 
ATOM   287  C CB  . THR A 1 98  ? 250.813 302.496 384.214 1.00 37.56 ? 98  THR A CB  1 
ATOM   288  O OG1 . THR A 1 98  ? 250.515 303.796 383.688 1.00 38.22 ? 98  THR A OG1 1 
ATOM   289  C CG2 . THR A 1 98  ? 252.254 302.133 383.891 1.00 37.12 ? 98  THR A CG2 1 
ATOM   290  N N   . LYS A 1 99  ? 247.413 301.761 383.452 1.00 37.55 ? 99  LYS A N   1 
ATOM   291  C CA  . LYS A 1 99  ? 246.081 301.939 384.023 1.00 37.06 ? 99  LYS A CA  1 
ATOM   292  C C   . LYS A 1 99  ? 245.571 300.661 384.681 1.00 38.82 ? 99  LYS A C   1 
ATOM   293  O O   . LYS A 1 99  ? 244.863 300.731 385.691 1.00 40.98 ? 99  LYS A O   1 
ATOM   294  C CB  . LYS A 1 99  ? 245.108 302.409 382.943 1.00 37.96 ? 99  LYS A CB  1 
ATOM   295  C CG  . LYS A 1 99  ? 245.409 303.800 382.397 1.00 37.74 ? 99  LYS A CG  1 
ATOM   296  C CD  . LYS A 1 99  ? 245.137 304.886 383.427 1.00 37.24 ? 99  LYS A CD  1 
ATOM   297  C CE  . LYS A 1 99  ? 245.374 306.277 382.853 1.00 37.57 ? 99  LYS A CE  1 
ATOM   298  N NZ  . LYS A 1 99  ? 244.435 306.610 381.743 1.00 38.95 ? 99  LYS A NZ  1 
ATOM   299  N N   . ARG A 1 100 ? 245.896 299.498 384.116 1.00 38.53 ? 100 ARG A N   1 
ATOM   300  C CA  . ARG A 1 100 ? 245.584 298.200 384.710 1.00 41.30 ? 100 ARG A CA  1 
ATOM   301  C C   . ARG A 1 100 ? 244.107 297.842 384.592 1.00 40.06 ? 100 ARG A C   1 
ATOM   302  O O   . ARG A 1 100 ? 243.712 296.721 384.926 1.00 41.58 ? 100 ARG A O   1 
ATOM   303  C CB  . ARG A 1 100 ? 246.000 298.164 386.185 1.00 41.17 ? 100 ARG A CB  1 
ATOM   304  C CG  . ARG A 1 100 ? 247.445 298.566 386.442 1.00 41.93 ? 100 ARG A CG  1 
ATOM   305  C CD  . ARG A 1 100 ? 248.413 297.759 385.595 1.00 42.18 ? 100 ARG A CD  1 
ATOM   306  N NE  . ARG A 1 100 ? 248.095 296.336 385.598 1.00 42.65 ? 100 ARG A NE  1 
ATOM   307  C CZ  . ARG A 1 100 ? 248.419 295.495 386.571 1.00 41.18 ? 100 ARG A CZ  1 
ATOM   308  N NH1 . ARG A 1 100 ? 249.055 295.903 387.658 1.00 41.11 ? 100 ARG A NH1 1 
ATOM   309  N NH2 . ARG A 1 100 ? 248.093 294.211 386.453 1.00 41.51 ? 100 ARG A NH2 1 
ATOM   310  N N   . ALA A 1 101 ? 243.283 298.775 384.113 1.00 37.48 ? 101 ALA A N   1 
ATOM   311  C CA  . ALA A 1 101 ? 241.888 298.496 383.812 1.00 38.01 ? 101 ALA A CA  1 
ATOM   312  C C   . ALA A 1 101 ? 241.611 298.431 382.321 1.00 37.12 ? 101 ALA A C   1 
ATOM   313  O O   . ALA A 1 101 ? 240.574 297.892 381.924 1.00 37.89 ? 101 ALA A O   1 
ATOM   314  C CB  . ALA A 1 101 ? 240.977 299.560 384.443 1.00 36.69 ? 101 ALA A CB  1 
ATOM   315  N N   . SER A 1 102 ? 242.509 298.961 381.497 1.00 33.61 ? 102 SER A N   1 
ATOM   316  C CA  . SER A 1 102 ? 242.343 298.933 380.054 1.00 28.68 ? 102 SER A CA  1 
ATOM   317  C C   . SER A 1 102 ? 243.006 297.689 379.477 1.00 25.50 ? 102 SER A C   1 
ATOM   318  O O   . SER A 1 102 ? 244.162 297.390 379.789 1.00 29.97 ? 102 SER A O   1 
ATOM   319  C CB  . SER A 1 102 ? 242.946 300.194 379.436 1.00 28.71 ? 102 SER A CB  1 
ATOM   320  O OG  . SER A 1 102 ? 242.408 301.357 380.040 1.00 31.29 ? 102 SER A OG  1 
ATOM   321  N N   . LYS A 1 103 ? 242.271 296.963 378.640 1.00 24.16 ? 103 LYS A N   1 
ATOM   322  C CA  . LYS A 1 103 ? 242.809 295.801 377.938 1.00 20.90 ? 103 LYS A CA  1 
ATOM   323  C C   . LYS A 1 103 ? 243.440 296.295 376.644 1.00 18.79 ? 103 LYS A C   1 
ATOM   324  O O   . LYS A 1 103 ? 242.743 296.595 375.673 1.00 22.68 ? 103 LYS A O   1 
ATOM   325  C CB  . LYS A 1 103 ? 241.717 294.773 377.669 1.00 23.77 ? 103 LYS A CB  1 
ATOM   326  C CG  . LYS A 1 103 ? 241.190 294.088 378.920 1.00 26.87 ? 103 LYS A CG  1 
ATOM   327  C CD  . LYS A 1 103 ? 240.008 293.177 378.617 1.00 27.10 ? 103 LYS A CD  1 
ATOM   328  C CE  . LYS A 1 103 ? 240.375 292.070 377.640 1.00 26.27 ? 103 LYS A CE  1 
ATOM   329  N NZ  . LYS A 1 103 ? 239.251 291.121 377.429 1.00 28.35 ? 103 LYS A NZ  1 
ATOM   330  N N   . LEU A 1 104 ? 244.770 296.376 376.626 1.00 18.00 ? 104 LEU A N   1 
ATOM   331  C CA  . LEU A 1 104 ? 245.458 296.875 375.444 1.00 20.40 ? 104 LEU A CA  1 
ATOM   332  C C   . LEU A 1 104 ? 245.427 295.878 374.296 1.00 12.74 ? 104 LEU A C   1 
ATOM   333  O O   . LEU A 1 104 ? 245.717 296.256 373.158 1.00 21.28 ? 104 LEU A O   1 
ATOM   334  C CB  . LEU A 1 104 ? 246.902 297.238 375.791 1.00 19.07 ? 104 LEU A CB  1 
ATOM   335  C CG  . LEU A 1 104 ? 247.081 298.368 376.810 1.00 19.36 ? 104 LEU A CG  1 
ATOM   336  C CD1 . LEU A 1 104 ? 248.544 298.767 376.906 1.00 24.01 ? 104 LEU A CD1 1 
ATOM   337  C CD2 . LEU A 1 104 ? 246.217 299.577 376.464 1.00 21.92 ? 104 LEU A CD2 1 
ATOM   338  N N   . PHE A 1 105 ? 245.080 294.623 374.564 1.00 18.81 ? 105 PHE A N   1 
ATOM   339  C CA  . PHE A 1 105 ? 244.890 293.644 373.507 1.00 12.03 ? 105 PHE A CA  1 
ATOM   340  C C   . PHE A 1 105 ? 243.894 292.604 373.991 1.00 10.25 ? 105 PHE A C   1 
ATOM   341  O O   . PHE A 1 105 ? 243.725 292.389 375.193 1.00 21.35 ? 105 PHE A O   1 
ATOM   342  C CB  . PHE A 1 105 ? 246.211 292.980 373.096 1.00 12.05 ? 105 PHE A CB  1 
ATOM   343  C CG  . PHE A 1 105 ? 246.708 291.961 374.079 1.00 13.01 ? 105 PHE A CG  1 
ATOM   344  C CD1 . PHE A 1 105 ? 247.376 292.355 375.225 1.00 12.81 ? 105 PHE A CD1 1 
ATOM   345  C CD2 . PHE A 1 105 ? 246.510 290.609 373.856 1.00 10.97 ? 105 PHE A CD2 1 
ATOM   346  C CE1 . PHE A 1 105 ? 247.835 291.422 376.130 1.00 13.21 ? 105 PHE A CE1 1 
ATOM   347  C CE2 . PHE A 1 105 ? 246.968 289.670 374.759 1.00 14.22 ? 105 PHE A CE2 1 
ATOM   348  C CZ  . PHE A 1 105 ? 247.632 290.076 375.896 1.00 15.67 ? 105 PHE A CZ  1 
ATOM   349  N N   . SER A 1 106 ? 243.231 291.961 373.036 1.00 10.72 ? 106 SER A N   1 
ATOM   350  C CA  . SER A 1 106 ? 242.201 290.979 373.341 1.00 12.99 ? 106 SER A CA  1 
ATOM   351  C C   . SER A 1 106 ? 242.363 289.766 372.441 1.00 10.99 ? 106 SER A C   1 
ATOM   352  O O   . SER A 1 106 ? 242.596 289.902 371.239 1.00 14.24 ? 106 SER A O   1 
ATOM   353  C CB  . SER A 1 106 ? 240.799 291.576 373.170 1.00 12.37 ? 106 SER A CB  1 
ATOM   354  O OG  . SER A 1 106 ? 239.802 290.629 373.500 1.00 25.95 ? 106 SER A OG  1 
ATOM   355  N N   . VAL A 1 107 ? 242.229 288.580 373.023 1.00 10.93 ? 107 VAL A N   1 
ATOM   356  C CA  . VAL A 1 107 ? 242.344 287.325 372.292 1.00 9.41  ? 107 VAL A CA  1 
ATOM   357  C C   . VAL A 1 107 ? 240.984 286.645 372.317 1.00 11.75 ? 107 VAL A C   1 
ATOM   358  O O   . VAL A 1 107 ? 240.433 286.378 373.391 1.00 23.29 ? 107 VAL A O   1 
ATOM   359  C CB  . VAL A 1 107 ? 243.432 286.419 372.890 1.00 8.57  ? 107 VAL A CB  1 
ATOM   360  C CG1 . VAL A 1 107 ? 243.551 285.129 372.090 1.00 7.36  ? 107 VAL A CG1 1 
ATOM   361  C CG2 . VAL A 1 107 ? 244.765 287.153 372.936 1.00 10.51 ? 107 VAL A CG2 1 
ATOM   362  N N   . TRP A 1 108 ? 240.444 286.367 371.134 1.00 10.13 ? 108 TRP A N   1 
ATOM   363  C CA  . TRP A 1 108 ? 239.145 285.724 370.984 1.00 10.01 ? 108 TRP A CA  1 
ATOM   364  C C   . TRP A 1 108 ? 239.334 284.408 370.248 1.00 11.92 ? 108 TRP A C   1 
ATOM   365  O O   . TRP A 1 108 ? 239.838 284.393 369.122 1.00 9.28  ? 108 TRP A O   1 
ATOM   366  C CB  . TRP A 1 108 ? 238.171 286.626 370.223 1.00 7.07  ? 108 TRP A CB  1 
ATOM   367  C CG  . TRP A 1 108 ? 236.917 285.925 369.791 1.00 9.85  ? 108 TRP A CG  1 
ATOM   368  C CD1 . TRP A 1 108 ? 235.888 285.520 370.589 1.00 10.17 ? 108 TRP A CD1 1 
ATOM   369  C CD2 . TRP A 1 108 ? 236.559 285.552 368.455 1.00 6.44  ? 108 TRP A CD2 1 
ATOM   370  N NE1 . TRP A 1 108 ? 234.914 284.916 369.834 1.00 11.55 ? 108 TRP A NE1 1 
ATOM   371  C CE2 . TRP A 1 108 ? 235.303 284.921 368.521 1.00 7.66  ? 108 TRP A CE2 1 
ATOM   372  C CE3 . TRP A 1 108 ? 237.180 285.688 367.211 1.00 12.54 ? 108 TRP A CE3 1 
ATOM   373  C CZ2 . TRP A 1 108 ? 234.653 284.432 367.390 1.00 9.39  ? 108 TRP A CZ2 1 
ATOM   374  C CZ3 . TRP A 1 108 ? 236.535 285.202 366.090 1.00 13.24 ? 108 TRP A CZ3 1 
ATOM   375  C CH2 . TRP A 1 108 ? 235.283 284.582 366.187 1.00 9.01  ? 108 TRP A CH2 1 
ATOM   376  N N   . LYS A 1 109 ? 238.934 283.311 370.881 1.00 9.85  ? 109 LYS A N   1 
ATOM   377  C CA  . LYS A 1 109 ? 238.990 282.017 370.218 1.00 7.87  ? 109 LYS A CA  1 
ATOM   378  C C   . LYS A 1 109 ? 237.931 281.959 369.124 1.00 7.78  ? 109 LYS A C   1 
ATOM   379  O O   . LYS A 1 109 ? 236.765 282.286 369.356 1.00 12.25 ? 109 LYS A O   1 
ATOM   380  C CB  . LYS A 1 109 ? 238.784 280.891 371.228 1.00 13.41 ? 109 LYS A CB  1 
ATOM   381  C CG  . LYS A 1 109 ? 239.136 279.517 370.686 1.00 12.88 ? 109 LYS A CG  1 
ATOM   382  C CD  . LYS A 1 109 ? 238.929 278.430 371.725 1.00 20.75 ? 109 LYS A CD  1 
ATOM   383  C CE  . LYS A 1 109 ? 239.384 277.074 371.208 1.00 17.66 ? 109 LYS A CE  1 
ATOM   384  N NZ  . LYS A 1 109 ? 238.704 276.689 369.940 1.00 21.78 ? 109 LYS A NZ  1 
ATOM   385  N N   . ILE A 1 110 ? 238.338 281.536 367.930 1.00 7.07  ? 110 ILE A N   1 
ATOM   386  C CA  . ILE A 1 110 ? 237.460 281.606 366.768 1.00 8.11  ? 110 ILE A CA  1 
ATOM   387  C C   . ILE A 1 110 ? 236.373 280.548 366.898 1.00 10.95 ? 110 ILE A C   1 
ATOM   388  O O   . ILE A 1 110 ? 236.660 279.353 367.031 1.00 14.95 ? 110 ILE A O   1 
ATOM   389  C CB  . ILE A 1 110 ? 238.257 281.431 365.470 1.00 10.36 ? 110 ILE A CB  1 
ATOM   390  C CG1 . ILE A 1 110 ? 239.241 282.594 365.293 1.00 9.15  ? 110 ILE A CG1 1 
ATOM   391  C CG2 . ILE A 1 110 ? 237.316 281.341 364.281 1.00 5.77  ? 110 ILE A CG2 1 
ATOM   392  C CD1 . ILE A 1 110 ? 240.355 282.311 364.310 1.00 12.02 ? 110 ILE A CD1 1 
ATOM   393  N N   . THR A 1 111 ? 235.118 280.985 366.860 1.00 13.79 ? 111 THR A N   1 
ATOM   394  C CA  . THR A 1 111 ? 233.985 280.080 366.988 1.00 11.82 ? 111 THR A CA  1 
ATOM   395  C C   . THR A 1 111 ? 232.732 280.804 366.526 1.00 9.13  ? 111 THR A C   1 
ATOM   396  O O   . THR A 1 111 ? 232.670 282.035 366.519 1.00 15.51 ? 111 THR A O   1 
ATOM   397  C CB  . THR A 1 111 ? 233.812 279.590 368.430 1.00 14.89 ? 111 THR A CB  1 
ATOM   398  O OG1 . THR A 1 111 ? 232.757 278.624 368.488 1.00 20.26 ? 111 THR A OG1 1 
ATOM   399  C CG2 . THR A 1 111 ? 233.472 280.747 369.353 1.00 15.48 ? 111 THR A CG2 1 
ATOM   400  N N   . TYR A 1 112 ? 231.731 280.019 366.141 1.00 12.42 ? 112 TYR A N   1 
ATOM   401  C CA  . TYR A 1 112 ? 230.409 280.540 365.830 1.00 8.25  ? 112 TYR A CA  1 
ATOM   402  C C   . TYR A 1 112 ? 229.436 280.390 366.991 1.00 10.50 ? 112 TYR A C   1 
ATOM   403  O O   . TYR A 1 112 ? 228.255 280.711 366.835 1.00 20.12 ? 112 TYR A O   1 
ATOM   404  C CB  . TYR A 1 112 ? 229.848 279.838 364.588 1.00 15.66 ? 112 TYR A CB  1 
ATOM   405  C CG  . TYR A 1 112 ? 229.592 278.359 364.778 1.00 10.21 ? 112 TYR A CG  1 
ATOM   406  C CD1 . TYR A 1 112 ? 228.397 277.904 365.316 1.00 12.41 ? 112 TYR A CD1 1 
ATOM   407  C CD2 . TYR A 1 112 ? 230.546 277.419 364.418 1.00 15.09 ? 112 TYR A CD2 1 
ATOM   408  C CE1 . TYR A 1 112 ? 228.160 276.554 365.490 1.00 12.27 ? 112 TYR A CE1 1 
ATOM   409  C CE2 . TYR A 1 112 ? 230.317 276.068 364.592 1.00 14.59 ? 112 TYR A CE2 1 
ATOM   410  C CZ  . TYR A 1 112 ? 229.126 275.641 365.125 1.00 12.19 ? 112 TYR A CZ  1 
ATOM   411  O OH  . TYR A 1 112 ? 228.905 274.295 365.291 1.00 28.69 ? 112 TYR A OH  1 
ATOM   412  N N   . LYS A 1 113 ? 229.895 279.913 368.146 1.00 11.45 ? 113 LYS A N   1 
ATOM   413  C CA  . LYS A 1 113 ? 229.013 279.584 369.258 1.00 13.30 ? 113 LYS A CA  1 
ATOM   414  C C   . LYS A 1 113 ? 228.897 280.691 370.296 1.00 10.32 ? 113 LYS A C   1 
ATOM   415  O O   . LYS A 1 113 ? 228.186 280.512 371.288 1.00 22.50 ? 113 LYS A O   1 
ATOM   416  C CB  . LYS A 1 113 ? 229.485 278.296 369.938 1.00 14.71 ? 113 LYS A CB  1 
ATOM   417  C CG  . LYS A 1 113 ? 229.319 277.060 369.077 1.00 17.52 ? 113 LYS A CG  1 
ATOM   418  C CD  . LYS A 1 113 ? 229.255 275.804 369.921 1.00 14.38 ? 113 LYS A CD  1 
ATOM   419  C CE  . LYS A 1 113 ? 228.992 274.575 369.069 1.00 17.04 ? 113 LYS A CE  1 
ATOM   420  N NZ  . LYS A 1 113 ? 230.193 274.144 368.309 1.00 24.89 ? 113 LYS A NZ  1 
ATOM   421  N N   . ASP A 1 114 ? 229.570 281.824 370.105 1.00 16.31 ? 114 ASP A N   1 
ATOM   422  C CA  . ASP A 1 114 ? 229.379 282.946 371.016 1.00 13.98 ? 114 ASP A CA  1 
ATOM   423  C C   . ASP A 1 114 ? 228.052 283.658 370.775 1.00 14.49 ? 114 ASP A C   1 
ATOM   424  O O   . ASP A 1 114 ? 227.539 284.312 371.688 1.00 19.69 ? 114 ASP A O   1 
ATOM   425  C CB  . ASP A 1 114 ? 230.542 283.929 370.886 1.00 13.37 ? 114 ASP A CB  1 
ATOM   426  C CG  . ASP A 1 114 ? 231.872 283.315 371.286 1.00 23.46 ? 114 ASP A CG  1 
ATOM   427  O OD1 . ASP A 1 114 ? 231.886 282.437 372.174 1.00 22.06 ? 114 ASP A OD1 1 
ATOM   428  O OD2 . ASP A 1 114 ? 232.906 283.710 370.710 1.00 28.58 ? 114 ASP A OD2 1 
ATOM   429  N N   . THR A 1 115 ? 227.490 283.541 369.577 1.00 17.40 ? 115 THR A N   1 
ATOM   430  C CA  . THR A 1 115 ? 226.160 284.036 369.256 1.00 13.87 ? 115 THR A CA  1 
ATOM   431  C C   . THR A 1 115 ? 225.289 282.857 368.835 1.00 11.18 ? 115 THR A C   1 
ATOM   432  O O   . THR A 1 115 ? 225.760 281.724 368.716 1.00 13.15 ? 115 THR A O   1 
ATOM   433  C CB  . THR A 1 115 ? 226.215 285.107 368.158 1.00 13.32 ? 115 THR A CB  1 
ATOM   434  O OG1 . THR A 1 115 ? 226.927 284.606 367.022 1.00 17.47 ? 115 THR A OG1 1 
ATOM   435  C CG2 . THR A 1 115 ? 226.904 286.358 368.673 1.00 13.57 ? 115 THR A CG2 1 
ATOM   436  N N   . VAL A 1 116 ? 224.004 283.125 368.606 1.00 12.22 ? 116 VAL A N   1 
ATOM   437  C CA  . VAL A 1 116 ? 223.001 282.075 368.495 1.00 7.01  ? 116 VAL A CA  1 
ATOM   438  C C   . VAL A 1 116 ? 222.440 281.957 367.082 1.00 8.66  ? 116 VAL A C   1 
ATOM   439  O O   . VAL A 1 116 ? 222.163 280.848 366.622 1.00 19.95 ? 116 VAL A O   1 
ATOM   440  C CB  . VAL A 1 116 ? 221.866 282.288 369.521 1.00 10.63 ? 116 VAL A CB  1 
ATOM   441  C CG1 . VAL A 1 116 ? 222.413 282.218 370.940 1.00 11.37 ? 116 VAL A CG1 1 
ATOM   442  C CG2 . VAL A 1 116 ? 221.150 283.610 369.281 1.00 14.55 ? 116 VAL A CG2 1 
ATOM   443  N N   . GLN A 1 117 ? 222.247 283.075 366.380 1.00 5.04  ? 117 GLN A N   1 
ATOM   444  C CA  . GLN A 1 117 ? 221.534 283.027 365.104 1.00 10.94 ? 117 GLN A CA  1 
ATOM   445  C C   . GLN A 1 117 ? 222.267 282.147 364.095 1.00 5.84  ? 117 GLN A C   1 
ATOM   446  O O   . GLN A 1 117 ? 221.724 281.146 363.600 1.00 18.47 ? 117 GLN A O   1 
ATOM   447  C CB  . GLN A 1 117 ? 221.345 284.444 364.555 1.00 10.51 ? 117 GLN A CB  1 
ATOM   448  C CG  . GLN A 1 117 ? 220.397 285.310 365.370 1.00 7.53  ? 117 GLN A CG  1 
ATOM   449  C CD  . GLN A 1 117 ? 220.000 286.593 364.657 1.00 14.14 ? 117 GLN A CD  1 
ATOM   450  O OE1 . GLN A 1 117 ? 220.683 287.050 363.739 1.00 20.21 ? 117 GLN A OE1 1 
ATOM   451  N NE2 . GLN A 1 117 ? 218.888 287.180 365.078 1.00 14.09 ? 117 GLN A NE2 1 
ATOM   452  N N   . LEU A 1 118 ? 223.514 282.507 363.781 1.00 8.00  ? 118 LEU A N   1 
ATOM   453  C CA  . LEU A 1 118 ? 224.304 281.681 362.878 1.00 8.12  ? 118 LEU A CA  1 
ATOM   454  C C   . LEU A 1 118 ? 224.471 280.278 363.438 1.00 4.71  ? 118 LEU A C   1 
ATOM   455  O O   . LEU A 1 118 ? 224.480 279.302 362.683 1.00 11.92 ? 118 LEU A O   1 
ATOM   456  C CB  . LEU A 1 118 ? 225.672 282.316 362.625 1.00 5.24  ? 118 LEU A CB  1 
ATOM   457  C CG  . LEU A 1 118 ? 226.583 281.526 361.678 1.00 6.67  ? 118 LEU A CG  1 
ATOM   458  C CD1 . LEU A 1 118 ? 225.915 281.338 360.322 1.00 6.61  ? 118 LEU A CD1 1 
ATOM   459  C CD2 . LEU A 1 118 ? 227.940 282.200 361.522 1.00 11.50 ? 118 LEU A CD2 1 
ATOM   460  N N   . ARG A 1 119 ? 224.616 280.156 364.759 1.00 7.14  ? 119 ARG A N   1 
ATOM   461  C CA  . ARG A 1 119 ? 224.759 278.837 365.363 1.00 10.53 ? 119 ARG A CA  1 
ATOM   462  C C   . ARG A 1 119 ? 223.548 277.964 365.062 1.00 5.67  ? 119 ARG A C   1 
ATOM   463  O O   . ARG A 1 119 ? 223.692 276.809 364.651 1.00 9.26  ? 119 ARG A O   1 
ATOM   464  C CB  . ARG A 1 119 ? 224.958 278.957 366.873 1.00 9.46  ? 119 ARG A CB  1 
ATOM   465  C CG  . ARG A 1 119 ? 225.041 277.608 367.572 1.00 5.63  ? 119 ARG A CG  1 
ATOM   466  C CD  . ARG A 1 119 ? 225.249 277.743 369.063 1.00 5.30  ? 119 ARG A CD  1 
ATOM   467  N NE  . ARG A 1 119 ? 225.435 276.443 369.693 1.00 6.40  ? 119 ARG A NE  1 
ATOM   468  C CZ  . ARG A 1 119 ? 225.705 276.262 370.978 1.00 12.37 ? 119 ARG A CZ  1 
ATOM   469  N NH1 . ARG A 1 119 ? 225.839 277.284 371.807 1.00 11.47 ? 119 ARG A NH1 1 
ATOM   470  N NH2 . ARG A 1 119 ? 225.834 275.024 371.445 1.00 9.05  ? 119 ARG A NH2 1 
ATOM   471  N N   . ARG A 1 120 ? 222.343 278.497 365.270 1.00 8.18  ? 120 ARG A N   1 
ATOM   472  C CA  . ARG A 1 120 ? 221.138 277.719 365.000 1.00 4.45  ? 120 ARG A CA  1 
ATOM   473  C C   . ARG A 1 120 ? 221.057 277.337 363.529 1.00 0.01  ? 120 ARG A C   1 
ATOM   474  O O   . ARG A 1 120 ? 220.779 276.175 363.190 1.00 12.83 ? 120 ARG A O   1 
ATOM   475  C CB  . ARG A 1 120 ? 219.903 278.514 365.418 1.00 4.54  ? 120 ARG A CB  1 
ATOM   476  C CG  . ARG A 1 120 ? 218.611 277.717 365.419 1.00 7.44  ? 120 ARG A CG  1 
ATOM   477  C CD  . ARG A 1 120 ? 217.542 278.459 366.188 1.00 7.33  ? 120 ARG A CD  1 
ATOM   478  N NE  . ARG A 1 120 ? 216.311 277.696 366.348 1.00 12.84 ? 120 ARG A NE  1 
ATOM   479  C CZ  . ARG A 1 120 ? 215.316 277.679 365.473 1.00 3.48  ? 120 ARG A CZ  1 
ATOM   480  N NH1 . ARG A 1 120 ? 215.391 278.331 364.326 1.00 5.04  ? 120 ARG A NH1 1 
ATOM   481  N NH2 . ARG A 1 120 ? 214.216 276.990 365.758 1.00 10.55 ? 120 ARG A NH2 1 
ATOM   482  N N   . LYS A 1 121 ? 221.330 278.293 362.639 1.00 5.40  ? 121 LYS A N   1 
ATOM   483  C CA  . LYS A 1 121 ? 221.259 277.989 361.213 1.00 10.27 ? 121 LYS A CA  1 
ATOM   484  C C   . LYS A 1 121 ? 222.237 276.880 360.843 1.00 1.37  ? 121 LYS A C   1 
ATOM   485  O O   . LYS A 1 121 ? 221.879 275.932 360.138 1.00 7.50  ? 121 LYS A O   1 
ATOM   486  C CB  . LYS A 1 121 ? 221.526 279.249 360.392 1.00 5.84  ? 121 LYS A CB  1 
ATOM   487  C CG  . LYS A 1 121 ? 220.427 280.291 360.517 1.00 5.65  ? 121 LYS A CG  1 
ATOM   488  C CD  . LYS A 1 121 ? 220.781 281.576 359.797 1.00 11.26 ? 121 LYS A CD  1 
ATOM   489  C CE  . LYS A 1 121 ? 220.784 281.405 358.292 1.00 5.59  ? 121 LYS A CE  1 
ATOM   490  N NZ  . LYS A 1 121 ? 221.224 282.651 357.605 1.00 15.47 ? 121 LYS A NZ  1 
ATOM   491  N N   . LEU A 1 122 ? 223.477 276.974 361.326 1.00 6.58  ? 122 LEU A N   1 
ATOM   492  C CA  . LEU A 1 122 ? 224.459 275.932 361.050 1.00 8.89  ? 122 LEU A CA  1 
ATOM   493  C C   . LEU A 1 122 ? 224.011 274.593 361.619 1.00 6.16  ? 122 LEU A C   1 
ATOM   494  O O   . LEU A 1 122 ? 224.113 273.560 360.949 1.00 6.08  ? 122 LEU A O   1 
ATOM   495  C CB  . LEU A 1 122 ? 225.820 276.324 361.629 1.00 3.84  ? 122 LEU A CB  1 
ATOM   496  C CG  . LEU A 1 122 ? 226.580 277.455 360.931 1.00 7.81  ? 122 LEU A CG  1 
ATOM   497  C CD1 . LEU A 1 122 ? 227.804 277.854 361.743 1.00 11.76 ? 122 LEU A CD1 1 
ATOM   498  C CD2 . LEU A 1 122 ? 226.976 277.059 359.521 1.00 4.52  ? 122 LEU A CD2 1 
ATOM   499  N N   . GLU A 1 123 ? 223.485 274.595 362.841 1.00 1.20  ? 123 GLU A N   1 
ATOM   500  C CA  . GLU A 1 123 ? 223.123 273.363 363.524 1.00 5.26  ? 123 GLU A CA  1 
ATOM   501  C C   . GLU A 1 123 ? 221.824 272.765 363.008 1.00 0.97  ? 123 GLU A C   1 
ATOM   502  O O   . GLU A 1 123 ? 221.414 271.709 363.498 1.00 17.75 ? 123 GLU A O   1 
ATOM   503  C CB  . GLU A 1 123 ? 223.040 273.605 365.032 1.00 5.90  ? 123 GLU A CB  1 
ATOM   504  C CG  . GLU A 1 123 ? 224.405 273.869 365.653 1.00 4.48  ? 123 GLU A CG  1 
ATOM   505  C CD  . GLU A 1 123 ? 224.369 273.963 367.160 1.00 10.96 ? 123 GLU A CD  1 
ATOM   506  O OE1 . GLU A 1 123 ? 223.267 273.902 367.738 1.00 20.08 ? 123 GLU A OE1 1 
ATOM   507  O OE2 . GLU A 1 123 ? 225.450 274.098 367.768 1.00 13.90 ? 123 GLU A OE2 1 
ATOM   508  N N   . PHE A 1 124 ? 221.170 273.408 362.039 1.00 3.61  ? 124 PHE A N   1 
ATOM   509  C CA  . PHE A 1 124 ? 220.215 272.672 361.217 1.00 5.75  ? 124 PHE A CA  1 
ATOM   510  C C   . PHE A 1 124 ? 220.838 271.427 360.593 1.00 6.41  ? 124 PHE A C   1 
ATOM   511  O O   . PHE A 1 124 ? 220.106 270.529 360.169 1.00 3.58  ? 124 PHE A O   1 
ATOM   512  C CB  . PHE A 1 124 ? 219.663 273.552 360.094 1.00 9.18  ? 124 PHE A CB  1 
ATOM   513  C CG  . PHE A 1 124 ? 218.331 274.170 360.398 1.00 7.26  ? 124 PHE A CG  1 
ATOM   514  C CD1 . PHE A 1 124 ? 217.158 273.469 360.164 1.00 11.96 ? 124 PHE A CD1 1 
ATOM   515  C CD2 . PHE A 1 124 ? 218.248 275.456 360.900 1.00 8.89  ? 124 PHE A CD2 1 
ATOM   516  C CE1 . PHE A 1 124 ? 215.929 274.037 360.433 1.00 8.27  ? 124 PHE A CE1 1 
ATOM   517  C CE2 . PHE A 1 124 ? 217.021 276.031 361.169 1.00 12.93 ? 124 PHE A CE2 1 
ATOM   518  C CZ  . PHE A 1 124 ? 215.861 275.321 360.936 1.00 10.32 ? 124 PHE A CZ  1 
ATOM   519  N N   . PHE A 1 125 ? 222.168 271.354 360.516 1.00 5.85  ? 125 PHE A N   1 
ATOM   520  C CA  . PHE A 1 125 ? 222.858 270.257 359.858 1.00 7.36  ? 125 PHE A CA  1 
ATOM   521  C C   . PHE A 1 125 ? 223.927 269.678 360.774 1.00 4.02  ? 125 PHE A C   1 
ATOM   522  O O   . PHE A 1 125 ? 224.407 270.333 361.702 1.00 8.45  ? 125 PHE A O   1 
ATOM   523  C CB  . PHE A 1 125 ? 223.487 270.718 358.541 1.00 5.47  ? 125 PHE A CB  1 
ATOM   524  C CG  . PHE A 1 125 ? 222.514 271.386 357.622 1.00 4.27  ? 125 PHE A CG  1 
ATOM   525  C CD1 . PHE A 1 125 ? 221.753 270.639 356.740 1.00 8.56  ? 125 PHE A CD1 1 
ATOM   526  C CD2 . PHE A 1 125 ? 222.345 272.758 357.650 1.00 2.53  ? 125 PHE A CD2 1 
ATOM   527  C CE1 . PHE A 1 125 ? 220.851 271.248 355.898 1.00 7.86  ? 125 PHE A CE1 1 
ATOM   528  C CE2 . PHE A 1 125 ? 221.442 273.371 356.809 1.00 10.22 ? 125 PHE A CE2 1 
ATOM   529  C CZ  . PHE A 1 125 ? 220.696 272.614 355.932 1.00 6.18  ? 125 PHE A CZ  1 
ATOM   530  N N   . THR A 1 126 ? 224.286 268.423 360.503 1.00 3.39  ? 126 THR A N   1 
ATOM   531  C CA  . THR A 1 126 ? 225.312 267.762 361.300 1.00 7.60  ? 126 THR A CA  1 
ATOM   532  C C   . THR A 1 126 ? 226.709 268.090 360.796 1.00 2.50  ? 126 THR A C   1 
ATOM   533  O O   . THR A 1 126 ? 227.604 268.369 361.599 1.00 2.41  ? 126 THR A O   1 
ATOM   534  C CB  . THR A 1 126 ? 225.115 266.247 361.295 1.00 1.61  ? 126 THR A CB  1 
ATOM   535  O OG1 . THR A 1 126 ? 223.800 265.921 361.754 1.00 10.74 ? 126 THR A OG1 1 
ATOM   536  C CG2 . THR A 1 126 ? 226.146 265.575 362.191 1.00 2.60  ? 126 THR A CG2 1 
ATOM   537  N N   . TYR A 1 127 ? 226.927 268.046 359.483 1.00 5.17  ? 127 TYR A N   1 
ATOM   538  C CA  . TYR A 1 127 ? 228.251 268.295 358.928 1.00 3.35  ? 127 TYR A CA  1 
ATOM   539  C C   . TYR A 1 127 ? 228.181 269.410 357.897 1.00 7.22  ? 127 TYR A C   1 
ATOM   540  O O   . TYR A 1 127 ? 227.194 269.531 357.169 1.00 7.20  ? 127 TYR A O   1 
ATOM   541  C CB  . TYR A 1 127 ? 228.842 267.032 358.291 1.00 4.12  ? 127 TYR A CB  1 
ATOM   542  C CG  . TYR A 1 127 ? 228.889 265.838 359.217 1.00 4.17  ? 127 TYR A CG  1 
ATOM   543  C CD1 . TYR A 1 127 ? 229.838 265.752 360.226 1.00 7.65  ? 127 TYR A CD1 1 
ATOM   544  C CD2 . TYR A 1 127 ? 227.986 264.793 359.078 1.00 2.82  ? 127 TYR A CD2 1 
ATOM   545  C CE1 . TYR A 1 127 ? 229.885 264.660 361.070 1.00 7.09  ? 127 TYR A CE1 1 
ATOM   546  C CE2 . TYR A 1 127 ? 228.024 263.699 359.915 1.00 3.69  ? 127 TYR A CE2 1 
ATOM   547  C CZ  . TYR A 1 127 ? 228.974 263.637 360.911 1.00 5.05  ? 127 TYR A CZ  1 
ATOM   548  O OH  . TYR A 1 127 ? 229.012 262.550 361.744 1.00 9.94  ? 127 TYR A OH  1 
ATOM   549  N N   . SER A 1 128 ? 229.232 270.221 357.837 1.00 11.91 ? 128 SER A N   1 
ATOM   550  C CA  . SER A 1 128 ? 229.298 271.308 356.874 1.00 7.33  ? 128 SER A CA  1 
ATOM   551  C C   . SER A 1 128 ? 230.705 271.410 356.308 1.00 5.84  ? 128 SER A C   1 
ATOM   552  O O   . SER A 1 128 ? 231.684 270.975 356.916 1.00 13.99 ? 128 SER A O   1 
ATOM   553  C CB  . SER A 1 128 ? 228.892 272.651 357.492 1.00 1.90  ? 128 SER A CB  1 
ATOM   554  O OG  . SER A 1 128 ? 229.813 273.060 358.484 1.00 15.91 ? 128 SER A OG  1 
ATOM   555  N N   . ARG A 1 129 ? 230.780 272.003 355.125 1.00 12.61 ? 129 ARG A N   1 
ATOM   556  C CA  . ARG A 1 129 ? 232.042 272.242 354.442 1.00 9.80  ? 129 ARG A CA  1 
ATOM   557  C C   . ARG A 1 129 ? 231.882 273.530 353.654 1.00 9.99  ? 129 ARG A C   1 
ATOM   558  O O   . ARG A 1 129 ? 231.044 273.601 352.750 1.00 12.69 ? 129 ARG A O   1 
ATOM   559  C CB  . ARG A 1 129 ? 232.394 271.071 353.526 1.00 10.10 ? 129 ARG A CB  1 
ATOM   560  C CG  . ARG A 1 129 ? 233.776 271.130 352.932 1.00 13.07 ? 129 ARG A CG  1 
ATOM   561  C CD  . ARG A 1 129 ? 233.972 270.033 351.899 1.00 9.70  ? 129 ARG A CD  1 
ATOM   562  N NE  . ARG A 1 129 ? 235.159 270.279 351.090 1.00 13.67 ? 129 ARG A NE  1 
ATOM   563  C CZ  . ARG A 1 129 ? 236.359 269.767 351.328 1.00 8.07  ? 129 ARG A CZ  1 
ATOM   564  N NH1 . ARG A 1 129 ? 236.568 268.920 352.323 1.00 9.39  ? 129 ARG A NH1 1 
ATOM   565  N NH2 . ARG A 1 129 ? 237.375 270.113 350.544 1.00 11.16 ? 129 ARG A NH2 1 
ATOM   566  N N   . PHE A 1 130 ? 232.654 274.552 354.011 1.00 10.82 ? 130 PHE A N   1 
ATOM   567  C CA  . PHE A 1 130 ? 232.539 275.837 353.340 1.00 8.61  ? 130 PHE A CA  1 
ATOM   568  C C   . PHE A 1 130 ? 233.814 276.636 353.546 1.00 8.59  ? 130 PHE A C   1 
ATOM   569  O O   . PHE A 1 130 ? 234.556 276.427 354.509 1.00 14.63 ? 130 PHE A O   1 
ATOM   570  C CB  . PHE A 1 130 ? 231.335 276.632 353.857 1.00 9.67  ? 130 PHE A CB  1 
ATOM   571  C CG  . PHE A 1 130 ? 231.332 276.834 355.345 1.00 4.57  ? 130 PHE A CG  1 
ATOM   572  C CD1 . PHE A 1 130 ? 232.096 277.828 355.928 1.00 9.88  ? 130 PHE A CD1 1 
ATOM   573  C CD2 . PHE A 1 130 ? 230.549 276.039 356.160 1.00 9.31  ? 130 PHE A CD2 1 
ATOM   574  C CE1 . PHE A 1 130 ? 232.086 278.016 357.289 1.00 13.08 ? 130 PHE A CE1 1 
ATOM   575  C CE2 . PHE A 1 130 ? 230.536 276.225 357.522 1.00 9.28  ? 130 PHE A CE2 1 
ATOM   576  C CZ  . PHE A 1 130 ? 231.300 277.216 358.085 1.00 5.94  ? 130 PHE A CZ  1 
ATOM   577  N N   . ASP A 1 131 ? 234.054 277.556 352.619 1.00 15.54 ? 131 ASP A N   1 
ATOM   578  C CA  . ASP A 1 131 ? 234.998 278.632 352.857 1.00 11.46 ? 131 ASP A CA  1 
ATOM   579  C C   . ASP A 1 131 ? 234.329 279.694 353.721 1.00 6.13  ? 131 ASP A C   1 
ATOM   580  O O   . ASP A 1 131 ? 233.106 279.757 353.822 1.00 16.13 ? 131 ASP A O   1 
ATOM   581  C CB  . ASP A 1 131 ? 235.472 279.235 351.536 1.00 7.68  ? 131 ASP A CB  1 
ATOM   582  C CG  . ASP A 1 131 ? 235.949 278.185 350.559 1.00 13.82 ? 131 ASP A CG  1 
ATOM   583  O OD1 . ASP A 1 131 ? 236.550 277.186 351.005 1.00 23.45 ? 131 ASP A OD1 1 
ATOM   584  O OD2 . ASP A 1 131 ? 235.720 278.353 349.345 1.00 16.84 ? 131 ASP A OD2 1 
ATOM   585  N N   . MET A 1 132 ? 235.138 280.528 354.356 1.00 13.29 ? 132 MET A N   1 
ATOM   586  C CA  . MET A 1 132 ? 234.629 281.537 355.271 1.00 12.15 ? 132 MET A CA  1 
ATOM   587  C C   . MET A 1 132 ? 235.077 282.919 354.822 1.00 11.70 ? 132 MET A C   1 
ATOM   588  O O   . MET A 1 132 ? 236.222 283.106 354.408 1.00 11.48 ? 132 MET A O   1 
ATOM   589  C CB  . MET A 1 132 ? 235.105 281.273 356.700 1.00 8.20  ? 132 MET A CB  1 
ATOM   590  C CG  . MET A 1 132 ? 234.604 282.285 357.711 1.00 18.98 ? 132 MET A CG  1 
ATOM   591  S SD  . MET A 1 132 ? 235.146 281.933 359.394 1.00 38.69 ? 132 MET A SD  1 
ATOM   592  C CE  . MET A 1 132 ? 236.922 282.076 359.218 1.00 22.60 ? 132 MET A CE  1 
ATOM   593  N N   . GLU A 1 133 ? 234.169 283.884 354.897 1.00 13.82 ? 133 GLU A N   1 
ATOM   594  C CA  . GLU A 1 133 ? 234.504 285.290 354.727 1.00 6.04  ? 133 GLU A CA  1 
ATOM   595  C C   . GLU A 1 133 ? 234.328 285.972 356.075 1.00 2.11  ? 133 GLU A C   1 
ATOM   596  O O   . GLU A 1 133 ? 233.256 285.881 356.683 1.00 11.72 ? 133 GLU A O   1 
ATOM   597  C CB  . GLU A 1 133 ? 233.627 285.943 353.660 1.00 10.69 ? 133 GLU A CB  1 
ATOM   598  C CG  . GLU A 1 133 ? 233.816 287.449 353.524 1.00 8.64  ? 133 GLU A CG  1 
ATOM   599  C CD  . GLU A 1 133 ? 232.837 288.066 352.545 1.00 17.33 ? 133 GLU A CD  1 
ATOM   600  O OE1 . GLU A 1 133 ? 233.012 287.874 351.325 1.00 23.54 ? 133 GLU A OE1 1 
ATOM   601  O OE2 . GLU A 1 133 ? 231.885 288.734 352.997 1.00 15.71 ? 133 GLU A OE2 1 
ATOM   602  N N   . LEU A 1 134 ? 235.381 286.628 356.548 1.00 8.56  ? 134 LEU A N   1 
ATOM   603  C CA  . LEU A 1 134 ? 235.346 287.386 357.788 1.00 5.42  ? 134 LEU A CA  1 
ATOM   604  C C   . LEU A 1 134 ? 235.373 288.872 357.472 1.00 4.15  ? 134 LEU A C   1 
ATOM   605  O O   . LEU A 1 134 ? 236.261 289.344 356.753 1.00 13.19 ? 134 LEU A O   1 
ATOM   606  C CB  . LEU A 1 134 ? 236.522 287.028 358.696 1.00 5.71  ? 134 LEU A CB  1 
ATOM   607  C CG  . LEU A 1 134 ? 236.523 285.621 359.290 1.00 14.15 ? 134 LEU A CG  1 
ATOM   608  C CD1 . LEU A 1 134 ? 237.675 285.474 360.269 1.00 13.16 ? 134 LEU A CD1 1 
ATOM   609  C CD2 . LEU A 1 134 ? 235.198 285.306 359.967 1.00 11.06 ? 134 LEU A CD2 1 
ATOM   610  N N   . THR A 1 135 ? 234.404 289.598 358.017 1.00 10.19 ? 135 THR A N   1 
ATOM   611  C CA  . THR A 1 135 ? 234.325 291.045 357.892 1.00 3.45  ? 135 THR A CA  1 
ATOM   612  C C   . THR A 1 135 ? 234.400 291.657 359.283 1.00 3.29  ? 135 THR A C   1 
ATOM   613  O O   . THR A 1 135 ? 233.649 291.270 360.180 1.00 12.76 ? 135 THR A O   1 
ATOM   614  C CB  . THR A 1 135 ? 233.037 291.468 357.181 1.00 8.45  ? 135 THR A CB  1 
ATOM   615  O OG1 . THR A 1 135 ? 232.909 290.742 355.953 1.00 15.66 ? 135 THR A OG1 1 
ATOM   616  C CG2 . THR A 1 135 ? 233.050 292.960 356.888 1.00 4.74  ? 135 THR A CG2 1 
ATOM   617  N N   . PHE A 1 136 ? 235.299 292.608 359.455 1.00 4.88  ? 136 PHE A N   1 
ATOM   618  C CA  . PHE A 1 136 ? 235.571 293.229 360.743 1.00 3.28  ? 136 PHE A CA  1 
ATOM   619  C C   . PHE A 1 136 ? 235.077 294.667 360.691 1.00 9.17  ? 136 PHE A C   1 
ATOM   620  O O   . PHE A 1 136 ? 235.594 295.480 359.913 1.00 13.90 ? 136 PHE A O   1 
ATOM   621  C CB  . PHE A 1 136 ? 237.062 293.163 361.064 1.00 4.29  ? 136 PHE A CB  1 
ATOM   622  C CG  . PHE A 1 136 ? 237.640 291.784 360.946 1.00 3.11  ? 136 PHE A CG  1 
ATOM   623  C CD1 . PHE A 1 136 ? 238.143 291.330 359.738 1.00 9.10  ? 136 PHE A CD1 1 
ATOM   624  C CD2 . PHE A 1 136 ? 237.677 290.939 362.040 1.00 5.79  ? 136 PHE A CD2 1 
ATOM   625  C CE1 . PHE A 1 136 ? 238.677 290.060 359.628 1.00 11.79 ? 136 PHE A CE1 1 
ATOM   626  C CE2 . PHE A 1 136 ? 238.210 289.670 361.934 1.00 7.70  ? 136 PHE A CE2 1 
ATOM   627  C CZ  . PHE A 1 136 ? 238.709 289.230 360.728 1.00 10.03 ? 136 PHE A CZ  1 
ATOM   628  N N   . VAL A 1 137 ? 234.074 294.967 361.513 1.00 7.98  ? 137 VAL A N   1 
ATOM   629  C CA  . VAL A 1 137 ? 233.531 296.312 361.654 1.00 4.70  ? 137 VAL A CA  1 
ATOM   630  C C   . VAL A 1 137 ? 234.089 296.895 362.942 1.00 6.86  ? 137 VAL A C   1 
ATOM   631  O O   . VAL A 1 137 ? 233.876 296.341 364.024 1.00 11.97 ? 137 VAL A O   1 
ATOM   632  C CB  . VAL A 1 137 ? 231.994 296.301 361.670 1.00 11.56 ? 137 VAL A CB  1 
ATOM   633  C CG1 . VAL A 1 137 ? 231.452 297.704 361.892 1.00 7.85  ? 137 VAL A CG1 1 
ATOM   634  C CG2 . VAL A 1 137 ? 231.453 295.712 360.378 1.00 10.37 ? 137 VAL A CG2 1 
ATOM   635  N N   . VAL A 1 138 ? 234.809 298.004 362.837 1.00 10.30 ? 138 VAL A N   1 
ATOM   636  C CA  . VAL A 1 138 ? 235.540 298.573 363.963 1.00 8.45  ? 138 VAL A CA  1 
ATOM   637  C C   . VAL A 1 138 ? 234.890 299.893 364.340 1.00 9.21  ? 138 VAL A C   1 
ATOM   638  O O   . VAL A 1 138 ? 234.770 300.797 363.505 1.00 16.52 ? 138 VAL A O   1 
ATOM   639  C CB  . VAL A 1 138 ? 237.025 298.769 363.627 1.00 9.07  ? 138 VAL A CB  1 
ATOM   640  C CG1 . VAL A 1 138 ? 237.802 299.191 364.866 1.00 5.44  ? 138 VAL A CG1 1 
ATOM   641  C CG2 . VAL A 1 138 ? 237.597 297.498 363.024 1.00 7.59  ? 138 VAL A CG2 1 
ATOM   642  N N   . THR A 1 139 ? 234.472 300.004 365.594 1.00 7.94  ? 139 THR A N   1 
ATOM   643  C CA  . THR A 1 139 ? 233.941 301.245 366.133 1.00 5.77  ? 139 THR A CA  1 
ATOM   644  C C   . THR A 1 139 ? 234.787 301.658 367.326 1.00 10.32 ? 139 THR A C   1 
ATOM   645  O O   . THR A 1 139 ? 235.357 300.813 368.015 1.00 18.27 ? 139 THR A O   1 
ATOM   646  C CB  . THR A 1 139 ? 232.469 301.102 366.553 1.00 12.14 ? 139 THR A CB  1 
ATOM   647  O OG1 . THR A 1 139 ? 232.322 299.982 367.435 1.00 19.28 ? 139 THR A OG1 1 
ATOM   648  C CG2 . THR A 1 139 ? 231.580 300.909 365.334 1.00 10.99 ? 139 THR A CG2 1 
ATOM   649  N N   . SER A 1 140 ? 234.887 302.963 367.556 1.00 8.66  ? 140 SER A N   1 
ATOM   650  C CA  . SER A 1 140 ? 235.685 303.468 368.662 1.00 12.18 ? 140 SER A CA  1 
ATOM   651  C C   . SER A 1 140 ? 235.022 304.711 369.230 1.00 11.68 ? 140 SER A C   1 
ATOM   652  O O   . SER A 1 140 ? 234.211 305.365 368.570 1.00 14.94 ? 140 SER A O   1 
ATOM   653  C CB  . SER A 1 140 ? 237.123 303.780 368.226 1.00 7.73  ? 140 SER A CB  1 
ATOM   654  O OG  . SER A 1 140 ? 237.954 304.014 369.348 1.00 14.27 ? 140 SER A OG  1 
ATOM   655  N N   . ASN A 1 141 ? 235.379 305.028 370.471 1.00 10.29 ? 141 ASN A N   1 
ATOM   656  C CA  . ASN A 1 141 ? 234.848 306.216 371.121 1.00 12.69 ? 141 ASN A CA  1 
ATOM   657  C C   . ASN A 1 141 ? 235.793 306.661 372.227 1.00 14.97 ? 141 ASN A C   1 
ATOM   658  O O   . ASN A 1 141 ? 236.568 305.869 372.777 1.00 19.71 ? 141 ASN A O   1 
ATOM   659  C CB  . ASN A 1 141 ? 233.446 305.965 371.690 1.00 15.70 ? 141 ASN A CB  1 
ATOM   660  C CG  . ASN A 1 141 ? 233.436 304.898 372.764 1.00 15.07 ? 141 ASN A CG  1 
ATOM   661  O OD1 . ASN A 1 141 ? 233.335 303.711 372.470 1.00 18.80 ? 141 ASN A OD1 1 
ATOM   662  N ND2 . ASN A 1 141 ? 233.547 305.317 374.017 1.00 19.95 ? 141 ASN A ND2 1 
ATOM   663  N N   . TYR A 1 142 ? 235.719 307.955 372.531 1.00 15.77 ? 142 TYR A N   1 
ATOM   664  C CA  . TYR A 1 142 ? 236.354 308.501 373.719 1.00 20.29 ? 142 TYR A CA  1 
ATOM   665  C C   . TYR A 1 142 ? 235.634 308.008 374.967 1.00 16.07 ? 142 TYR A C   1 
ATOM   666  O O   . TYR A 1 142 ? 234.432 307.734 374.951 1.00 22.15 ? 142 TYR A O   1 
ATOM   667  C CB  . TYR A 1 142 ? 236.329 310.033 373.696 1.00 19.60 ? 142 TYR A CB  1 
ATOM   668  C CG  . TYR A 1 142 ? 237.162 310.679 372.611 1.00 17.43 ? 142 TYR A CG  1 
ATOM   669  C CD1 . TYR A 1 142 ? 238.523 310.885 372.785 1.00 19.14 ? 142 TYR A CD1 1 
ATOM   670  C CD2 . TYR A 1 142 ? 236.581 311.109 371.425 1.00 19.17 ? 142 TYR A CD2 1 
ATOM   671  C CE1 . TYR A 1 142 ? 239.286 311.480 371.802 1.00 18.95 ? 142 TYR A CE1 1 
ATOM   672  C CE2 . TYR A 1 142 ? 237.336 311.707 370.436 1.00 16.44 ? 142 TYR A CE2 1 
ATOM   673  C CZ  . TYR A 1 142 ? 238.689 311.892 370.630 1.00 19.73 ? 142 TYR A CZ  1 
ATOM   674  O OH  . TYR A 1 142 ? 239.447 312.488 369.651 1.00 22.55 ? 142 TYR A OH  1 
ATOM   675  N N   . THR A 1 143 ? 236.384 307.904 376.063 1.00 22.88 ? 143 THR A N   1 
ATOM   676  C CA  . THR A 1 143 ? 235.820 307.537 377.352 1.00 21.65 ? 143 THR A CA  1 
ATOM   677  C C   . THR A 1 143 ? 235.698 308.710 378.312 1.00 25.92 ? 143 THR A C   1 
ATOM   678  O O   . THR A 1 143 ? 234.999 308.589 379.321 1.00 30.18 ? 143 THR A O   1 
ATOM   679  C CB  . THR A 1 143 ? 236.669 306.441 378.013 1.00 24.84 ? 143 THR A CB  1 
ATOM   680  O OG1 . THR A 1 143 ? 238.002 306.924 378.214 1.00 29.60 ? 143 THR A OG1 1 
ATOM   681  C CG2 . THR A 1 143 ? 236.707 305.200 377.138 1.00 21.88 ? 143 THR A CG2 1 
ATOM   682  N N   . ASP A 1 144 ? 236.355 309.831 378.026 1.00 30.18 ? 144 ASP A N   1 
ATOM   683  C CA  . ASP A 1 144 ? 236.231 311.033 378.838 1.00 27.76 ? 144 ASP A CA  1 
ATOM   684  C C   . ASP A 1 144 ? 236.566 312.229 377.961 1.00 31.45 ? 144 ASP A C   1 
ATOM   685  O O   . ASP A 1 144 ? 237.144 312.085 376.881 1.00 36.54 ? 144 ASP A O   1 
ATOM   686  C CB  . ASP A 1 144 ? 237.140 310.981 380.070 1.00 32.19 ? 144 ASP A CB  1 
ATOM   687  C CG  . ASP A 1 144 ? 238.604 310.841 379.708 1.00 35.38 ? 144 ASP A CG  1 
ATOM   688  O OD1 . ASP A 1 144 ? 238.897 310.320 378.613 1.00 38.18 ? 144 ASP A OD1 1 
ATOM   689  O OD2 . ASP A 1 144 ? 239.460 311.250 380.520 1.00 34.61 ? 144 ASP A OD2 1 
ATOM   690  N N   . ALA A 1 145 ? 236.196 313.414 378.441 1.00 33.45 ? 145 ALA A N   1 
ATOM   691  C CA  . ALA A 1 145 ? 236.288 314.633 377.650 1.00 33.26 ? 145 ALA A CA  1 
ATOM   692  C C   . ALA A 1 145 ? 237.380 315.586 378.114 1.00 34.05 ? 145 ALA A C   1 
ATOM   693  O O   . ALA A 1 145 ? 237.604 316.606 377.455 1.00 35.05 ? 145 ALA A O   1 
ATOM   694  C CB  . ALA A 1 145 ? 234.939 315.363 377.664 1.00 29.46 ? 145 ALA A CB  1 
ATOM   695  N N   . ASN A 1 146 ? 238.073 315.287 379.214 1.00 36.20 ? 146 ASN A N   1 
ATOM   696  C CA  . ASN A 1 146 ? 238.994 316.229 379.840 1.00 34.29 ? 146 ASN A CA  1 
ATOM   697  C C   . ASN A 1 146 ? 240.456 315.811 379.696 1.00 33.23 ? 146 ASN A C   1 
ATOM   698  O O   . ASN A 1 146 ? 241.290 316.177 380.527 1.00 36.46 ? 146 ASN A O   1 
ATOM   699  C CB  . ASN A 1 146 ? 238.646 316.403 381.318 1.00 33.62 ? 146 ASN A CB  1 
ATOM   700  C CG  . ASN A 1 146 ? 237.208 316.827 381.532 1.00 37.07 ? 146 ASN A CG  1 
ATOM   701  O OD1 . ASN A 1 146 ? 236.338 315.997 381.800 1.00 37.10 ? 146 ASN A OD1 1 
ATOM   702  N ND2 . ASN A 1 146 ? 236.948 318.122 381.414 1.00 35.14 ? 146 ASN A ND2 1 
ATOM   703  N N   . ASN A 1 147 ? 240.787 315.051 378.649 1.00 32.71 ? 147 ASN A N   1 
ATOM   704  C CA  . ASN A 1 147 ? 242.164 314.617 378.441 1.00 33.48 ? 147 ASN A CA  1 
ATOM   705  C C   . ASN A 1 147 ? 242.589 314.756 376.983 1.00 32.11 ? 147 ASN A C   1 
ATOM   706  O O   . ASN A 1 147 ? 243.377 313.946 376.484 1.00 34.26 ? 147 ASN A O   1 
ATOM   707  C CB  . ASN A 1 147 ? 242.360 313.172 378.906 1.00 31.38 ? 147 ASN A CB  1 
ATOM   708  C CG  . ASN A 1 147 ? 242.400 313.048 380.415 1.00 34.23 ? 147 ASN A CG  1 
ATOM   709  O OD1 . ASN A 1 147 ? 243.428 313.304 381.041 1.00 35.37 ? 147 ASN A OD1 1 
ATOM   710  N ND2 . ASN A 1 147 ? 241.279 312.656 381.008 1.00 32.97 ? 147 ASN A ND2 1 
ATOM   711  N N   . GLY A 1 148 ? 242.093 315.775 376.292 1.00 30.13 ? 148 GLY A N   1 
ATOM   712  C CA  . GLY A 1 148 ? 242.507 316.011 374.927 1.00 27.49 ? 148 GLY A CA  1 
ATOM   713  C C   . GLY A 1 148 ? 241.879 315.034 373.949 1.00 29.34 ? 148 GLY A C   1 
ATOM   714  O O   . GLY A 1 148 ? 240.886 314.359 374.237 1.00 30.94 ? 148 GLY A O   1 
ATOM   715  N N   . HIS A 1 149 ? 242.487 314.959 372.771 1.00 26.18 ? 149 HIS A N   1 
ATOM   716  C CA  . HIS A 1 149 ? 241.954 314.213 371.641 1.00 26.19 ? 149 HIS A CA  1 
ATOM   717  C C   . HIS A 1 149 ? 242.951 313.145 371.205 1.00 21.29 ? 149 HIS A C   1 
ATOM   718  O O   . HIS A 1 149 ? 244.006 312.956 371.815 1.00 24.36 ? 149 HIS A O   1 
ATOM   719  C CB  . HIS A 1 149 ? 241.616 315.161 370.488 1.00 23.04 ? 149 HIS A CB  1 
ATOM   720  C CG  . HIS A 1 149 ? 240.618 316.214 370.854 1.00 27.89 ? 149 HIS A CG  1 
ATOM   721  N ND1 . HIS A 1 149 ? 240.792 317.064 371.925 1.00 30.18 ? 149 HIS A ND1 1 
ATOM   722  C CD2 . HIS A 1 149 ? 239.432 316.549 370.297 1.00 30.85 ? 149 HIS A CD2 1 
ATOM   723  C CE1 . HIS A 1 149 ? 239.755 317.876 372.014 1.00 25.75 ? 149 HIS A CE1 1 
ATOM   724  N NE2 . HIS A 1 149 ? 238.919 317.589 371.034 1.00 33.05 ? 149 HIS A NE2 1 
ATOM   725  N N   . ALA A 1 150 ? 242.600 312.435 370.137 1.00 19.66 ? 150 ALA A N   1 
ATOM   726  C CA  . ALA A 1 150 ? 243.403 311.328 369.648 1.00 19.19 ? 150 ALA A CA  1 
ATOM   727  C C   . ALA A 1 150 ? 243.518 311.409 368.134 1.00 14.64 ? 150 ALA A C   1 
ATOM   728  O O   . ALA A 1 150 ? 242.673 311.991 367.454 1.00 23.22 ? 150 ALA A O   1 
ATOM   729  C CB  . ALA A 1 150 ? 242.804 309.979 370.056 1.00 19.89 ? 150 ALA A CB  1 
ATOM   730  N N   . LEU A 1 151 ? 244.589 310.822 367.617 1.00 17.38 ? 151 LEU A N   1 
ATOM   731  C CA  . LEU A 1 151 ? 244.769 310.677 366.183 1.00 15.06 ? 151 LEU A CA  1 
ATOM   732  C C   . LEU A 1 151 ? 244.187 309.343 365.728 1.00 11.81 ? 151 LEU A C   1 
ATOM   733  O O   . LEU A 1 151 ? 243.990 308.423 366.523 1.00 19.20 ? 151 LEU A O   1 
ATOM   734  C CB  . LEU A 1 151 ? 246.249 310.778 365.816 1.00 15.92 ? 151 LEU A CB  1 
ATOM   735  C CG  . LEU A 1 151 ? 246.924 312.089 366.233 1.00 20.88 ? 151 LEU A CG  1 
ATOM   736  C CD1 . LEU A 1 151 ? 248.398 312.080 365.873 1.00 17.15 ? 151 LEU A CD1 1 
ATOM   737  C CD2 . LEU A 1 151 ? 246.226 313.290 365.603 1.00 15.44 ? 151 LEU A CD2 1 
ATOM   738  N N   . ASN A 1 152 ? 243.911 309.250 364.430 1.00 15.61 ? 152 ASN A N   1 
ATOM   739  C CA  . ASN A 1 152 ? 243.218 308.083 363.901 1.00 10.43 ? 152 ASN A CA  1 
ATOM   740  C C   . ASN A 1 152 ? 243.970 306.808 364.264 1.00 12.54 ? 152 ASN A C   1 
ATOM   741  O O   . ASN A 1 152 ? 245.185 306.711 364.077 1.00 15.59 ? 152 ASN A O   1 
ATOM   742  C CB  . ASN A 1 152 ? 243.069 308.197 362.386 1.00 10.08 ? 152 ASN A CB  1 
ATOM   743  C CG  . ASN A 1 152 ? 241.975 307.300 361.844 1.00 10.25 ? 152 ASN A CG  1 
ATOM   744  O OD1 . ASN A 1 152 ? 240.794 307.539 362.079 1.00 17.39 ? 152 ASN A OD1 1 
ATOM   745  N ND2 . ASN A 1 152 ? 242.362 306.270 361.104 1.00 9.08  ? 152 ASN A ND2 1 
ATOM   746  N N   . GLN A 1 153 ? 243.238 305.829 364.779 1.00 10.40 ? 153 GLN A N   1 
ATOM   747  C CA  . GLN A 1 153 ? 243.837 304.605 365.282 1.00 11.45 ? 153 GLN A CA  1 
ATOM   748  C C   . GLN A 1 153 ? 244.019 303.588 364.166 1.00 6.28  ? 153 GLN A C   1 
ATOM   749  O O   . GLN A 1 153 ? 243.248 303.540 363.204 1.00 8.92  ? 153 GLN A O   1 
ATOM   750  C CB  . GLN A 1 153 ? 242.976 303.996 366.387 1.00 8.37  ? 153 GLN A CB  1 
ATOM   751  C CG  . GLN A 1 153 ? 242.787 304.894 367.588 1.00 10.94 ? 153 GLN A CG  1 
ATOM   752  C CD  . GLN A 1 153 ? 241.790 304.334 368.576 1.00 12.91 ? 153 GLN A CD  1 
ATOM   753  O OE1 . GLN A 1 153 ? 242.162 303.663 369.536 1.00 18.52 ? 153 GLN A OE1 1 
ATOM   754  N NE2 . GLN A 1 153 ? 240.512 304.610 368.348 1.00 15.99 ? 153 GLN A NE2 1 
ATOM   755  N N   . VAL A 1 154 ? 245.056 302.772 364.308 1.00 10.29 ? 154 VAL A N   1 
ATOM   756  C CA  . VAL A 1 154 ? 245.289 301.619 363.450 1.00 11.56 ? 154 VAL A CA  1 
ATOM   757  C C   . VAL A 1 154 ? 245.220 300.378 364.325 1.00 5.22  ? 154 VAL A C   1 
ATOM   758  O O   . VAL A 1 154 ? 245.794 300.350 365.419 1.00 18.45 ? 154 VAL A O   1 
ATOM   759  C CB  . VAL A 1 154 ? 246.640 301.711 362.718 1.00 8.19  ? 154 VAL A CB  1 
ATOM   760  C CG1 . VAL A 1 154 ? 246.921 300.431 361.942 1.00 7.38  ? 154 VAL A CG1 1 
ATOM   761  C CG2 . VAL A 1 154 ? 246.655 302.915 361.790 1.00 7.33  ? 154 VAL A CG2 1 
ATOM   762  N N   . TYR A 1 155 ? 244.506 299.366 363.851 1.00 8.51  ? 155 TYR A N   1 
ATOM   763  C CA  . TYR A 1 155 ? 244.269 298.140 364.592 1.00 6.65  ? 155 TYR A CA  1 
ATOM   764  C C   . TYR A 1 155 ? 244.986 296.987 363.910 1.00 10.52 ? 155 TYR A C   1 
ATOM   765  O O   . TYR A 1 155 ? 244.954 296.868 362.684 1.00 9.16  ? 155 TYR A O   1 
ATOM   766  C CB  . TYR A 1 155 ? 242.771 297.830 364.675 1.00 7.88  ? 155 TYR A CB  1 
ATOM   767  C CG  . TYR A 1 155 ? 241.944 298.922 365.305 1.00 11.12 ? 155 TYR A CG  1 
ATOM   768  C CD1 . TYR A 1 155 ? 241.618 300.072 364.597 1.00 5.49  ? 155 TYR A CD1 1 
ATOM   769  C CD2 . TYR A 1 155 ? 241.481 298.802 366.607 1.00 11.07 ? 155 TYR A CD2 1 
ATOM   770  C CE1 . TYR A 1 155 ? 240.863 301.071 365.171 1.00 8.63  ? 155 TYR A CE1 1 
ATOM   771  C CE2 . TYR A 1 155 ? 240.723 299.796 367.186 1.00 8.97  ? 155 TYR A CE2 1 
ATOM   772  C CZ  . TYR A 1 155 ? 240.419 300.928 366.465 1.00 6.31  ? 155 TYR A CZ  1 
ATOM   773  O OH  . TYR A 1 155 ? 239.665 301.920 367.039 1.00 16.61 ? 155 TYR A OH  1 
ATOM   774  N N   . GLN A 1 156 ? 245.635 296.146 364.702 1.00 11.41 ? 156 GLN A N   1 
ATOM   775  C CA  . GLN A 1 156 ? 246.181 294.892 364.209 1.00 5.99  ? 156 GLN A CA  1 
ATOM   776  C C   . GLN A 1 156 ? 245.268 293.757 364.648 1.00 2.48  ? 156 GLN A C   1 
ATOM   777  O O   . GLN A 1 156 ? 244.939 293.639 365.834 1.00 11.42 ? 156 GLN A O   1 
ATOM   778  C CB  . GLN A 1 156 ? 247.605 294.655 364.715 1.00 3.28  ? 156 GLN A CB  1 
ATOM   779  C CG  . GLN A 1 156 ? 248.269 293.434 364.088 1.00 3.96  ? 156 GLN A CG  1 
ATOM   780  C CD  . GLN A 1 156 ? 249.722 293.266 364.492 1.00 6.55  ? 156 GLN A CD  1 
ATOM   781  O OE1 . GLN A 1 156 ? 250.262 294.065 365.252 1.00 13.73 ? 156 GLN A OE1 1 
ATOM   782  N NE2 . GLN A 1 156 ? 250.361 292.222 363.981 1.00 5.03  ? 156 GLN A NE2 1 
ATOM   783  N N   . ILE A 1 157 ? 244.847 292.944 363.683 1.00 6.24  ? 157 ILE A N   1 
ATOM   784  C CA  . ILE A 1 157 ? 244.069 291.735 363.925 1.00 4.31  ? 157 ILE A CA  1 
ATOM   785  C C   . ILE A 1 157 ? 244.923 290.589 363.402 1.00 3.54  ? 157 ILE A C   1 
ATOM   786  O O   . ILE A 1 157 ? 245.027 290.389 362.187 1.00 11.61 ? 157 ILE A O   1 
ATOM   787  C CB  . ILE A 1 157 ? 242.701 291.771 363.232 1.00 9.64  ? 157 ILE A CB  1 
ATOM   788  C CG1 . ILE A 1 157 ? 241.916 293.017 363.652 1.00 8.96  ? 157 ILE A CG1 1 
ATOM   789  C CG2 . ILE A 1 157 ? 241.912 290.503 363.540 1.00 10.03 ? 157 ILE A CG2 1 
ATOM   790  C CD1 . ILE A 1 157 ? 240.672 293.257 362.828 1.00 12.96 ? 157 ILE A CD1 1 
ATOM   791  N N   . MET A 1 158 ? 245.556 289.852 364.305 1.00 6.90  ? 158 MET A N   1 
ATOM   792  C CA  . MET A 1 158 ? 246.459 288.772 363.942 1.00 6.74  ? 158 MET A CA  1 
ATOM   793  C C   . MET A 1 158 ? 245.765 287.438 364.162 1.00 6.16  ? 158 MET A C   1 
ATOM   794  O O   . MET A 1 158 ? 245.229 287.180 365.243 1.00 16.14 ? 158 MET A O   1 
ATOM   795  C CB  . MET A 1 158 ? 247.747 288.841 364.764 1.00 5.79  ? 158 MET A CB  1 
ATOM   796  C CG  . MET A 1 158 ? 248.759 287.759 364.419 1.00 10.01 ? 158 MET A CG  1 
ATOM   797  S SD  . MET A 1 158 ? 250.362 288.011 365.200 1.00 11.31 ? 158 MET A SD  1 
ATOM   798  C CE  . MET A 1 158 ? 249.907 288.012 366.930 1.00 5.87  ? 158 MET A CE  1 
ATOM   799  N N   . PHE A 1 159 ? 245.768 286.602 363.135 1.00 3.70  ? 159 PHE A N   1 
ATOM   800  C CA  . PHE A 1 159 ? 245.284 285.239 363.273 1.00 7.01  ? 159 PHE A CA  1 
ATOM   801  C C   . PHE A 1 159 ? 246.388 284.386 363.880 1.00 4.86  ? 159 PHE A C   1 
ATOM   802  O O   . PHE A 1 159 ? 247.485 284.288 363.322 1.00 10.88 ? 159 PHE A O   1 
ATOM   803  C CB  . PHE A 1 159 ? 244.846 284.688 361.920 1.00 4.32  ? 159 PHE A CB  1 
ATOM   804  C CG  . PHE A 1 159 ? 244.561 283.216 361.931 1.00 14.25 ? 159 PHE A CG  1 
ATOM   805  C CD1 . PHE A 1 159 ? 243.948 282.620 363.024 1.00 14.44 ? 159 PHE A CD1 1 
ATOM   806  C CD2 . PHE A 1 159 ? 244.891 282.428 360.846 1.00 10.54 ? 159 PHE A CD2 1 
ATOM   807  C CE1 . PHE A 1 159 ? 243.684 281.273 363.034 1.00 11.51 ? 159 PHE A CE1 1 
ATOM   808  C CE2 . PHE A 1 159 ? 244.626 281.074 360.851 1.00 16.83 ? 159 PHE A CE2 1 
ATOM   809  C CZ  . PHE A 1 159 ? 244.024 280.497 361.947 1.00 14.94 ? 159 PHE A CZ  1 
ATOM   810  N N   . ILE A 1 160 ? 246.100 283.781 365.025 1.00 10.27 ? 160 ILE A N   1 
ATOM   811  C CA  . ILE A 1 160 ? 247.032 282.895 365.710 1.00 7.32  ? 160 ILE A CA  1 
ATOM   812  C C   . ILE A 1 160 ? 246.511 281.476 365.531 1.00 7.15  ? 160 ILE A C   1 
ATOM   813  O O   . ILE A 1 160 ? 245.592 281.062 366.251 1.00 10.40 ? 160 ILE A O   1 
ATOM   814  C CB  . ILE A 1 160 ? 247.164 283.267 367.195 1.00 6.98  ? 160 ILE A CB  1 
ATOM   815  C CG1 . ILE A 1 160 ? 247.572 284.735 367.331 1.00 12.26 ? 160 ILE A CG1 1 
ATOM   816  C CG2 . ILE A 1 160 ? 248.174 282.356 367.886 1.00 9.20  ? 160 ILE A CG2 1 
ATOM   817  C CD1 . ILE A 1 160 ? 247.452 285.272 368.725 1.00 16.96 ? 160 ILE A CD1 1 
ATOM   818  N N   . PRO A 1 161 ? 247.045 280.706 364.587 1.00 9.81  ? 161 PRO A N   1 
ATOM   819  C CA  . PRO A 1 161 ? 246.616 279.318 364.437 1.00 8.81  ? 161 PRO A CA  1 
ATOM   820  C C   . PRO A 1 161 ? 247.031 278.497 365.643 1.00 6.73  ? 161 PRO A C   1 
ATOM   821  O O   . PRO A 1 161 ? 247.959 278.880 366.370 1.00 13.13 ? 161 PRO A O   1 
ATOM   822  C CB  . PRO A 1 161 ? 247.340 278.853 363.163 1.00 8.91  ? 161 PRO A CB  1 
ATOM   823  C CG  . PRO A 1 161 ? 247.756 280.099 362.469 1.00 8.79  ? 161 PRO A CG  1 
ATOM   824  C CD  . PRO A 1 161 ? 248.012 281.093 363.547 1.00 8.15  ? 161 PRO A CD  1 
ATOM   825  N N   . PRO A 1 162 ? 246.365 277.374 365.899 1.00 17.95 ? 162 PRO A N   1 
ATOM   826  C CA  . PRO A 1 162 ? 246.718 276.559 367.068 1.00 11.12 ? 162 PRO A CA  1 
ATOM   827  C C   . PRO A 1 162 ? 248.204 276.227 367.098 1.00 6.51  ? 162 PRO A C   1 
ATOM   828  O O   . PRO A 1 162 ? 248.775 275.753 366.114 1.00 10.40 ? 162 PRO A O   1 
ATOM   829  C CB  . PRO A 1 162 ? 245.859 275.302 366.891 1.00 8.32  ? 162 PRO A CB  1 
ATOM   830  C CG  . PRO A 1 162 ? 244.706 275.743 366.072 1.00 10.58 ? 162 PRO A CG  1 
ATOM   831  C CD  . PRO A 1 162 ? 245.222 276.811 365.159 1.00 11.54 ? 162 PRO A CD  1 
ATOM   832  N N   . GLY A 1 163 ? 248.828 276.479 368.247 1.00 11.32 ? 163 GLY A N   1 
ATOM   833  C CA  . GLY A 1 163 ? 250.234 276.226 368.454 1.00 6.31  ? 163 GLY A CA  1 
ATOM   834  C C   . GLY A 1 163 ? 251.120 277.452 368.365 1.00 13.61 ? 163 GLY A C   1 
ATOM   835  O O   . GLY A 1 163 ? 252.203 277.456 368.959 1.00 17.67 ? 163 GLY A O   1 
ATOM   836  N N   . ALA A 1 164 ? 250.693 278.487 367.649 1.00 8.42  ? 164 ALA A N   1 
ATOM   837  C CA  . ALA A 1 164 ? 251.490 279.696 367.555 1.00 5.43  ? 164 ALA A CA  1 
ATOM   838  C C   . ALA A 1 164 ? 251.443 280.463 368.877 1.00 2.32  ? 164 ALA A C   1 
ATOM   839  O O   . ALA A 1 164 ? 250.433 280.435 369.584 1.00 16.54 ? 164 ALA A O   1 
ATOM   840  C CB  . ALA A 1 164 ? 250.992 280.580 366.416 1.00 7.41  ? 164 ALA A CB  1 
ATOM   841  N N   . PRO A 1 165 ? 252.521 281.160 369.231 1.00 10.98 ? 165 PRO A N   1 
ATOM   842  C CA  . PRO A 1 165 ? 252.561 281.835 370.535 1.00 10.72 ? 165 PRO A CA  1 
ATOM   843  C C   . PRO A 1 165 ? 251.490 282.911 370.648 1.00 9.69  ? 165 PRO A C   1 
ATOM   844  O O   . PRO A 1 165 ? 251.373 283.792 369.795 1.00 15.99 ? 165 PRO A O   1 
ATOM   845  C CB  . PRO A 1 165 ? 253.974 282.430 370.582 1.00 10.33 ? 165 PRO A CB  1 
ATOM   846  C CG  . PRO A 1 165 ? 254.380 282.560 369.160 1.00 11.64 ? 165 PRO A CG  1 
ATOM   847  C CD  . PRO A 1 165 ? 253.736 281.416 368.440 1.00 11.34 ? 165 PRO A CD  1 
ATOM   848  N N   . ILE A 1 166 ? 250.706 282.825 371.713 1.00 13.46 ? 166 ILE A N   1 
ATOM   849  C CA  . ILE A 1 166 ? 249.691 283.839 372.005 1.00 13.12 ? 166 ILE A CA  1 
ATOM   850  C C   . ILE A 1 166 ? 250.385 285.068 372.587 1.00 9.20  ? 166 ILE A C   1 
ATOM   851  O O   . ILE A 1 166 ? 251.247 284.918 373.466 1.00 15.68 ? 166 ILE A O   1 
ATOM   852  C CB  . ILE A 1 166 ? 248.649 283.287 372.976 1.00 14.05 ? 166 ILE A CB  1 
ATOM   853  C CG1 . ILE A 1 166 ? 248.010 282.007 372.423 1.00 13.26 ? 166 ILE A CG1 1 
ATOM   854  C CG2 . ILE A 1 166 ? 247.581 284.331 373.269 1.00 15.99 ? 166 ILE A CG2 1 
ATOM   855  C CD1 . ILE A 1 166 ? 247.081 282.227 371.252 1.00 13.82 ? 166 ILE A CD1 1 
ATOM   856  N N   . PRO A 1 167 ? 250.056 286.280 372.138 1.00 16.38 ? 167 PRO A N   1 
ATOM   857  C CA  . PRO A 1 167 ? 250.676 287.466 372.740 1.00 15.12 ? 167 PRO A CA  1 
ATOM   858  C C   . PRO A 1 167 ? 250.357 287.565 374.225 1.00 11.49 ? 167 PRO A C   1 
ATOM   859  O O   . PRO A 1 167 ? 249.248 287.256 374.664 1.00 20.41 ? 167 PRO A O   1 
ATOM   860  C CB  . PRO A 1 167 ? 250.067 288.632 371.949 1.00 7.90  ? 167 PRO A CB  1 
ATOM   861  C CG  . PRO A 1 167 ? 248.843 288.083 371.319 1.00 15.15 ? 167 PRO A CG  1 
ATOM   862  C CD  . PRO A 1 167 ? 249.117 286.640 371.063 1.00 13.51 ? 167 PRO A CD  1 
ATOM   863  N N   . GLY A 1 168 ? 251.349 287.997 374.998 1.00 19.30 ? 168 GLY A N   1 
ATOM   864  C CA  . GLY A 1 168 ? 251.176 288.200 376.423 1.00 14.33 ? 168 GLY A CA  1 
ATOM   865  C C   . GLY A 1 168 ? 251.075 289.670 376.770 1.00 11.03 ? 168 GLY A C   1 
ATOM   866  O O   . GLY A 1 168 ? 250.506 290.039 377.800 1.00 17.10 ? 168 GLY A O   1 
ATOM   867  N N   . LYS A 1 169 ? 251.633 290.516 375.910 1.00 18.56 ? 169 LYS A N   1 
ATOM   868  C CA  . LYS A 1 169 ? 251.576 291.959 376.065 1.00 12.45 ? 169 LYS A CA  1 
ATOM   869  C C   . LYS A 1 169 ? 251.232 292.586 374.724 1.00 13.99 ? 169 LYS A C   1 
ATOM   870  O O   . LYS A 1 169 ? 251.490 292.014 373.662 1.00 19.69 ? 169 LYS A O   1 
ATOM   871  C CB  . LYS A 1 169 ? 252.903 292.526 376.589 1.00 14.40 ? 169 LYS A CB  1 
ATOM   872  C CG  . LYS A 1 169 ? 253.301 291.986 377.948 1.00 20.18 ? 169 LYS A CG  1 
ATOM   873  C CD  . LYS A 1 169 ? 254.583 292.622 378.455 1.00 22.02 ? 169 LYS A CD  1 
ATOM   874  C CE  . LYS A 1 169 ? 254.939 292.114 379.844 1.00 21.86 ? 169 LYS A CE  1 
ATOM   875  N NZ  . LYS A 1 169 ? 256.169 292.754 380.385 1.00 25.66 ? 169 LYS A NZ  1 
ATOM   876  N N   . TRP A 1 170 ? 250.649 293.782 374.783 1.00 17.27 ? 170 TRP A N   1 
ATOM   877  C CA  . TRP A 1 170 ? 250.181 294.434 373.568 1.00 14.19 ? 170 TRP A CA  1 
ATOM   878  C C   . TRP A 1 170 ? 251.315 294.715 372.590 1.00 14.52 ? 170 TRP A C   1 
ATOM   879  O O   . TRP A 1 170 ? 251.055 294.905 371.399 1.00 18.74 ? 170 TRP A O   1 
ATOM   880  C CB  . TRP A 1 170 ? 249.458 295.734 373.919 1.00 17.23 ? 170 TRP A CB  1 
ATOM   881  C CG  . TRP A 1 170 ? 250.374 296.891 374.143 1.00 18.18 ? 170 TRP A CG  1 
ATOM   882  C CD1 . TRP A 1 170 ? 251.123 297.140 375.253 1.00 16.75 ? 170 TRP A CD1 1 
ATOM   883  C CD2 . TRP A 1 170 ? 250.638 297.964 373.231 1.00 16.40 ? 170 TRP A CD2 1 
ATOM   884  N NE1 . TRP A 1 170 ? 251.840 298.299 375.090 1.00 21.50 ? 170 TRP A NE1 1 
ATOM   885  C CE2 . TRP A 1 170 ? 251.560 298.824 373.856 1.00 17.19 ? 170 TRP A CE2 1 
ATOM   886  C CE3 . TRP A 1 170 ? 250.184 298.279 371.946 1.00 15.54 ? 170 TRP A CE3 1 
ATOM   887  C CZ2 . TRP A 1 170 ? 252.038 299.979 373.242 1.00 17.38 ? 170 TRP A CZ2 1 
ATOM   888  C CZ3 . TRP A 1 170 ? 250.660 299.425 371.337 1.00 19.66 ? 170 TRP A CZ3 1 
ATOM   889  C CH2 . TRP A 1 170 ? 251.577 300.262 371.985 1.00 21.87 ? 170 TRP A CH2 1 
ATOM   890  N N   . ASN A 1 171 ? 252.564 294.734 373.058 1.00 13.13 ? 171 ASN A N   1 
ATOM   891  C CA  . ASN A 1 171 ? 253.698 295.096 372.217 1.00 17.95 ? 171 ASN A CA  1 
ATOM   892  C C   . ASN A 1 171 ? 254.819 294.065 372.301 1.00 13.88 ? 171 ASN A C   1 
ATOM   893  O O   . ASN A 1 171 ? 255.985 294.399 372.080 1.00 24.49 ? 171 ASN A O   1 
ATOM   894  C CB  . ASN A 1 171 ? 254.222 296.482 372.592 1.00 19.45 ? 171 ASN A CB  1 
ATOM   895  C CG  . ASN A 1 171 ? 254.708 296.553 374.026 1.00 21.46 ? 171 ASN A CG  1 
ATOM   896  O OD1 . ASN A 1 171 ? 254.370 295.707 374.851 1.00 27.20 ? 171 ASN A OD1 1 
ATOM   897  N ND2 . ASN A 1 171 ? 255.501 297.572 374.331 1.00 23.91 ? 171 ASN A ND2 1 
ATOM   898  N N   . ASP A 1 172 ? 254.494 292.810 372.606 1.00 14.02 ? 172 ASP A N   1 
ATOM   899  C CA  . ASP A 1 172 ? 255.524 291.785 372.672 1.00 14.95 ? 172 ASP A CA  1 
ATOM   900  C C   . ASP A 1 172 ? 255.916 291.341 371.261 1.00 10.52 ? 172 ASP A C   1 
ATOM   901  O O   . ASP A 1 172 ? 255.359 291.793 370.257 1.00 14.90 ? 172 ASP A O   1 
ATOM   902  C CB  . ASP A 1 172 ? 255.063 290.610 373.539 1.00 11.76 ? 172 ASP A CB  1 
ATOM   903  C CG  . ASP A 1 172 ? 253.980 289.766 372.888 1.00 17.57 ? 172 ASP A CG  1 
ATOM   904  O OD1 . ASP A 1 172 ? 253.645 289.980 371.707 1.00 21.24 ? 172 ASP A OD1 1 
ATOM   905  O OD2 . ASP A 1 172 ? 253.456 288.869 373.579 1.00 23.67 ? 172 ASP A OD2 1 
ATOM   906  N N   . TYR A 1 173 ? 256.895 290.438 371.189 1.00 14.07 ? 173 TYR A N   1 
ATOM   907  C CA  . TYR A 1 173 ? 257.480 290.067 369.905 1.00 14.70 ? 173 TYR A CA  1 
ATOM   908  C C   . TYR A 1 173 ? 256.454 289.453 368.960 1.00 6.27  ? 173 TYR A C   1 
ATOM   909  O O   . TYR A 1 173 ? 256.581 289.589 367.738 1.00 15.32 ? 173 TYR A O   1 
ATOM   910  C CB  . TYR A 1 173 ? 258.634 289.087 370.129 1.00 16.12 ? 173 TYR A CB  1 
ATOM   911  C CG  . TYR A 1 173 ? 258.171 287.725 370.586 1.00 12.34 ? 173 TYR A CG  1 
ATOM   912  C CD1 . TYR A 1 173 ? 257.896 287.477 371.923 1.00 13.80 ? 173 TYR A CD1 1 
ATOM   913  C CD2 . TYR A 1 173 ? 257.998 286.690 369.679 1.00 11.38 ? 173 TYR A CD2 1 
ATOM   914  C CE1 . TYR A 1 173 ? 257.462 286.237 372.344 1.00 14.93 ? 173 TYR A CE1 1 
ATOM   915  C CE2 . TYR A 1 173 ? 257.566 285.446 370.091 1.00 14.88 ? 173 TYR A CE2 1 
ATOM   916  C CZ  . TYR A 1 173 ? 257.300 285.225 371.424 1.00 15.02 ? 173 TYR A CZ  1 
ATOM   917  O OH  . TYR A 1 173 ? 256.870 283.988 371.840 1.00 23.37 ? 173 TYR A OH  1 
ATOM   918  N N   . THR A 1 174 ? 255.431 288.783 369.498 1.00 5.72  ? 174 THR A N   1 
ATOM   919  C CA  . THR A 1 174 ? 254.525 288.007 368.654 1.00 10.07 ? 174 THR A CA  1 
ATOM   920  C C   . THR A 1 174 ? 253.838 288.870 367.604 1.00 9.39  ? 174 THR A C   1 
ATOM   921  O O   . THR A 1 174 ? 253.441 288.360 366.551 1.00 14.31 ? 174 THR A O   1 
ATOM   922  C CB  . THR A 1 174 ? 253.463 287.306 369.505 1.00 14.06 ? 174 THR A CB  1 
ATOM   923  O OG1 . THR A 1 174 ? 252.665 288.287 370.176 1.00 20.11 ? 174 THR A OG1 1 
ATOM   924  C CG2 . THR A 1 174 ? 254.106 286.383 370.533 1.00 12.17 ? 174 THR A CG2 1 
ATOM   925  N N   . TRP A 1 175 ? 253.674 290.166 367.868 1.00 8.35  ? 175 TRP A N   1 
ATOM   926  C CA  . TRP A 1 175 ? 252.979 291.029 366.923 1.00 11.67 ? 175 TRP A CA  1 
ATOM   927  C C   . TRP A 1 175 ? 253.789 291.289 365.658 1.00 5.96  ? 175 TRP A C   1 
ATOM   928  O O   . TRP A 1 175 ? 253.243 291.849 364.703 1.00 8.80  ? 175 TRP A O   1 
ATOM   929  C CB  . TRP A 1 175 ? 252.609 292.347 367.603 1.00 8.30  ? 175 TRP A CB  1 
ATOM   930  C CG  . TRP A 1 175 ? 251.686 292.161 368.775 1.00 9.34  ? 175 TRP A CG  1 
ATOM   931  C CD1 . TRP A 1 175 ? 252.028 292.160 370.094 1.00 6.63  ? 175 TRP A CD1 1 
ATOM   932  C CD2 . TRP A 1 175 ? 250.271 291.935 368.728 1.00 9.30  ? 175 TRP A CD2 1 
ATOM   933  N NE1 . TRP A 1 175 ? 250.917 291.955 370.871 1.00 12.13 ? 175 TRP A NE1 1 
ATOM   934  C CE2 . TRP A 1 175 ? 249.825 291.812 370.057 1.00 6.03  ? 175 TRP A CE2 1 
ATOM   935  C CE3 . TRP A 1 175 ? 249.338 291.828 367.690 1.00 6.52  ? 175 TRP A CE3 1 
ATOM   936  C CZ2 . TRP A 1 175 ? 248.488 291.591 370.378 1.00 10.34 ? 175 TRP A CZ2 1 
ATOM   937  C CZ3 . TRP A 1 175 ? 248.011 291.605 368.011 1.00 5.65  ? 175 TRP A CZ3 1 
ATOM   938  C CH2 . TRP A 1 175 ? 247.598 291.491 369.342 1.00 4.08  ? 175 TRP A CH2 1 
ATOM   939  N N   . GLN A 1 176 ? 255.063 290.884 365.623 1.00 4.52  ? 176 GLN A N   1 
ATOM   940  C CA  . GLN A 1 176 ? 255.820 290.930 364.375 1.00 9.63  ? 176 GLN A CA  1 
ATOM   941  C C   . GLN A 1 176 ? 255.124 290.139 363.276 1.00 8.59  ? 176 GLN A C   1 
ATOM   942  O O   . GLN A 1 176 ? 255.281 290.455 362.093 1.00 14.10 ? 176 GLN A O   1 
ATOM   943  C CB  . GLN A 1 176 ? 257.233 290.387 364.592 1.00 12.67 ? 176 GLN A CB  1 
ATOM   944  C CG  . GLN A 1 176 ? 258.075 291.193 365.560 1.00 13.35 ? 176 GLN A CG  1 
ATOM   945  C CD  . GLN A 1 176 ? 259.375 290.496 365.911 1.00 16.39 ? 176 GLN A CD  1 
ATOM   946  O OE1 . GLN A 1 176 ? 259.820 289.597 365.200 1.00 17.24 ? 176 GLN A OE1 1 
ATOM   947  N NE2 . GLN A 1 176 ? 259.985 290.903 367.014 1.00 14.35 ? 176 GLN A NE2 1 
ATOM   948  N N   . THR A 1 177 ? 254.377 289.099 363.650 1.00 6.91  ? 177 THR A N   1 
ATOM   949  C CA  . THR A 1 177 ? 253.477 288.373 362.749 1.00 7.02  ? 177 THR A CA  1 
ATOM   950  C C   . THR A 1 177 ? 254.179 287.968 361.452 1.00 9.78  ? 177 THR A C   1 
ATOM   951  O O   . THR A 1 177 ? 253.639 288.100 360.353 1.00 21.04 ? 177 THR A O   1 
ATOM   952  C CB  . THR A 1 177 ? 252.205 289.193 362.468 1.00 11.48 ? 177 THR A CB  1 
ATOM   953  O OG1 . THR A 1 177 ? 251.259 288.391 361.751 1.00 12.45 ? 177 THR A OG1 1 
ATOM   954  C CG2 . THR A 1 177 ? 252.491 290.470 361.669 1.00 8.89  ? 177 THR A CG2 1 
ATOM   955  N N   . SER A 1 178 ? 255.397 287.439 361.591 1.00 13.26 ? 178 SER A N   1 
ATOM   956  C CA  . SER A 1 178 ? 256.169 287.062 360.411 1.00 8.93  ? 178 SER A CA  1 
ATOM   957  C C   . SER A 1 178 ? 255.509 285.923 359.645 1.00 10.79 ? 178 SER A C   1 
ATOM   958  O O   . SER A 1 178 ? 255.640 285.848 358.420 1.00 18.16 ? 178 SER A O   1 
ATOM   959  C CB  . SER A 1 178 ? 257.589 286.666 360.808 1.00 9.93  ? 178 SER A CB  1 
ATOM   960  O OG  . SER A 1 178 ? 257.660 285.287 361.121 1.00 13.94 ? 178 SER A OG  1 
ATOM   961  N N   . SER A 1 179 ? 254.810 285.033 360.340 1.00 8.98  ? 179 SER A N   1 
ATOM   962  C CA  . SER A 1 179 ? 254.131 283.906 359.718 1.00 10.90 ? 179 SER A CA  1 
ATOM   963  C C   . SER A 1 179 ? 252.631 283.893 359.963 1.00 9.36  ? 179 SER A C   1 
ATOM   964  O O   . SER A 1 179 ? 251.896 283.330 359.152 1.00 14.20 ? 179 SER A O   1 
ATOM   965  C CB  . SER A 1 179 ? 254.730 282.583 360.220 1.00 5.61  ? 179 SER A CB  1 
ATOM   966  O OG  . SER A 1 179 ? 256.106 282.492 359.903 1.00 13.17 ? 179 SER A OG  1 
ATOM   967  N N   . ASN A 1 180 ? 252.164 284.489 361.050 1.00 10.48 ? 180 ASN A N   1 
ATOM   968  C CA  . ASN A 1 180 ? 250.732 284.653 361.255 1.00 7.25  ? 180 ASN A CA  1 
ATOM   969  C C   . ASN A 1 180 ? 250.185 285.656 360.247 1.00 9.82  ? 180 ASN A C   1 
ATOM   970  O O   . ASN A 1 180 ? 250.774 286.728 360.070 1.00 13.18 ? 180 ASN A O   1 
ATOM   971  C CB  . ASN A 1 180 ? 250.438 285.146 362.669 1.00 13.58 ? 180 ASN A CB  1 
ATOM   972  C CG  . ASN A 1 180 ? 250.744 284.115 363.730 1.00 7.23  ? 180 ASN A CG  1 
ATOM   973  O OD1 . ASN A 1 180 ? 250.970 282.946 363.432 1.00 11.78 ? 180 ASN A OD1 1 
ATOM   974  N ND2 . ASN A 1 180 ? 250.740 284.546 364.982 1.00 8.38  ? 180 ASN A ND2 1 
ATOM   975  N N   . PRO A 1 181 ? 249.077 285.364 359.573 1.00 13.04 ? 181 PRO A N   1 
ATOM   976  C CA  . PRO A 1 181 ? 248.403 286.423 358.817 1.00 9.87  ? 181 PRO A CA  1 
ATOM   977  C C   . PRO A 1 181 ? 247.907 287.502 359.766 1.00 3.61  ? 181 PRO A C   1 
ATOM   978  O O   . PRO A 1 181 ? 247.340 287.212 360.821 1.00 16.03 ? 181 PRO A O   1 
ATOM   979  C CB  . PRO A 1 181 ? 247.247 285.693 358.122 1.00 9.07  ? 181 PRO A CB  1 
ATOM   980  C CG  . PRO A 1 181 ? 247.569 284.249 358.214 1.00 12.25 ? 181 PRO A CG  1 
ATOM   981  C CD  . PRO A 1 181 ? 248.373 284.077 359.456 1.00 12.74 ? 181 PRO A CD  1 
ATOM   982  N N   . SER A 1 182 ? 248.134 288.754 359.390 1.00 6.98  ? 182 SER A N   1 
ATOM   983  C CA  . SER A 1 182 ? 247.631 289.896 360.137 1.00 8.23  ? 182 SER A CA  1 
ATOM   984  C C   . SER A 1 182 ? 246.960 290.864 359.180 1.00 3.76  ? 182 SER A C   1 
ATOM   985  O O   . SER A 1 182 ? 247.412 291.048 358.047 1.00 10.24 ? 182 SER A O   1 
ATOM   986  C CB  . SER A 1 182 ? 248.748 290.619 360.899 1.00 4.46  ? 182 SER A CB  1 
ATOM   987  O OG  . SER A 1 182 ? 249.000 290.005 362.145 1.00 12.00 ? 182 SER A OG  1 
ATOM   988  N N   . VAL A 1 183 ? 245.877 291.475 359.641 1.00 7.76  ? 183 VAL A N   1 
ATOM   989  C CA  . VAL A 1 183 ? 245.217 292.556 358.925 1.00 7.89  ? 183 VAL A CA  1 
ATOM   990  C C   . VAL A 1 183 ? 245.388 293.819 359.749 1.00 2.96  ? 183 VAL A C   1 
ATOM   991  O O   . VAL A 1 183 ? 245.008 293.861 360.926 1.00 12.95 ? 183 VAL A O   1 
ATOM   992  C CB  . VAL A 1 183 ? 243.732 292.259 358.667 1.00 9.46  ? 183 VAL A CB  1 
ATOM   993  C CG1 . VAL A 1 183 ? 243.025 293.515 358.179 1.00 11.01 ? 183 VAL A CG1 1 
ATOM   994  C CG2 . VAL A 1 183 ? 243.589 291.153 357.648 1.00 11.12 ? 183 VAL A CG2 1 
ATOM   995  N N   . PHE A 1 184 ? 245.975 294.839 359.139 1.00 4.57  ? 184 PHE A N   1 
ATOM   996  C CA  . PHE A 1 184 ? 246.049 296.162 359.733 1.00 7.98  ? 184 PHE A CA  1 
ATOM   997  C C   . PHE A 1 184 ? 244.910 296.992 359.160 1.00 4.35  ? 184 PHE A C   1 
ATOM   998  O O   . PHE A 1 184 ? 244.849 297.222 357.948 1.00 11.55 ? 184 PHE A O   1 
ATOM   999  C CB  . PHE A 1 184 ? 247.406 296.811 359.467 1.00 4.39  ? 184 PHE A CB  1 
ATOM   1000 C CG  . PHE A 1 184 ? 248.539 296.133 360.178 1.00 5.14  ? 184 PHE A CG  1 
ATOM   1001 C CD1 . PHE A 1 184 ? 249.173 295.042 359.610 1.00 2.94  ? 184 PHE A CD1 1 
ATOM   1002 C CD2 . PHE A 1 184 ? 248.957 296.572 361.421 1.00 5.58  ? 184 PHE A CD2 1 
ATOM   1003 C CE1 . PHE A 1 184 ? 250.211 294.410 360.265 1.00 8.18  ? 184 PHE A CE1 1 
ATOM   1004 C CE2 . PHE A 1 184 ? 249.996 295.942 362.079 1.00 1.93  ? 184 PHE A CE2 1 
ATOM   1005 C CZ  . PHE A 1 184 ? 250.621 294.860 361.501 1.00 6.07  ? 184 PHE A CZ  1 
ATOM   1006 N N   . TYR A 1 185 ? 244.000 297.405 360.029 1.00 10.47 ? 185 TYR A N   1 
ATOM   1007 C CA  . TYR A 1 185 ? 242.821 298.162 359.643 1.00 7.66  ? 185 TYR A CA  1 
ATOM   1008 C C   . TYR A 1 185 ? 242.963 299.596 360.125 1.00 2.33  ? 185 TYR A C   1 
ATOM   1009 O O   . TYR A 1 185 ? 243.280 299.837 361.292 1.00 5.92  ? 185 TYR A O   1 
ATOM   1010 C CB  . TYR A 1 185 ? 241.549 297.537 360.220 1.00 2.85  ? 185 TYR A CB  1 
ATOM   1011 C CG  . TYR A 1 185 ? 240.358 298.452 360.097 1.00 7.31  ? 185 TYR A CG  1 
ATOM   1012 C CD1 . TYR A 1 185 ? 239.646 298.540 358.909 1.00 8.73  ? 185 TYR A CD1 1 
ATOM   1013 C CD2 . TYR A 1 185 ? 239.962 299.252 361.160 1.00 3.75  ? 185 TYR A CD2 1 
ATOM   1014 C CE1 . TYR A 1 185 ? 238.568 299.386 358.789 1.00 6.69  ? 185 TYR A CE1 1 
ATOM   1015 C CE2 . TYR A 1 185 ? 238.886 300.099 361.048 1.00 8.35  ? 185 TYR A CE2 1 
ATOM   1016 C CZ  . TYR A 1 185 ? 238.192 300.165 359.862 1.00 7.28  ? 185 TYR A CZ  1 
ATOM   1017 O OH  . TYR A 1 185 ? 237.118 301.011 359.749 1.00 11.81 ? 185 TYR A OH  1 
ATOM   1018 N N   . THR A 1 186 ? 242.712 300.541 359.230 1.00 3.62  ? 186 THR A N   1 
ATOM   1019 C CA  . THR A 1 186 ? 242.750 301.954 359.569 1.00 11.27 ? 186 THR A CA  1 
ATOM   1020 C C   . THR A 1 186 ? 241.345 302.412 359.928 1.00 6.57  ? 186 THR A C   1 
ATOM   1021 O O   . THR A 1 186 ? 240.394 302.148 359.187 1.00 11.87 ? 186 THR A O   1 
ATOM   1022 C CB  . THR A 1 186 ? 243.298 302.772 358.399 1.00 8.49  ? 186 THR A CB  1 
ATOM   1023 O OG1 . THR A 1 186 ? 244.555 302.226 357.984 1.00 13.71 ? 186 THR A OG1 1 
ATOM   1024 C CG2 . THR A 1 186 ? 243.482 304.231 358.797 1.00 9.18  ? 186 THR A CG2 1 
ATOM   1025 N N   . TYR A 1 187 ? 241.216 303.087 361.065 1.00 7.86  ? 187 TYR A N   1 
ATOM   1026 C CA  . TYR A 1 187 ? 239.901 303.515 361.519 1.00 5.80  ? 187 TYR A CA  1 
ATOM   1027 C C   . TYR A 1 187 ? 239.279 304.490 360.528 1.00 7.52  ? 187 TYR A C   1 
ATOM   1028 O O   . TYR A 1 187 ? 239.933 305.415 360.041 1.00 9.78  ? 187 TYR A O   1 
ATOM   1029 C CB  . TYR A 1 187 ? 239.989 304.157 362.900 1.00 8.69  ? 187 TYR A CB  1 
ATOM   1030 C CG  . TYR A 1 187 ? 238.634 304.330 363.540 1.00 9.22  ? 187 TYR A CG  1 
ATOM   1031 C CD1 . TYR A 1 187 ? 237.983 303.255 364.129 1.00 8.78  ? 187 TYR A CD1 1 
ATOM   1032 C CD2 . TYR A 1 187 ? 237.996 305.562 363.540 1.00 12.68 ? 187 TYR A CD2 1 
ATOM   1033 C CE1 . TYR A 1 187 ? 236.739 303.403 364.709 1.00 12.02 ? 187 TYR A CE1 1 
ATOM   1034 C CE2 . TYR A 1 187 ? 236.750 305.722 364.118 1.00 12.29 ? 187 TYR A CE2 1 
ATOM   1035 C CZ  . TYR A 1 187 ? 236.127 304.638 364.701 1.00 13.48 ? 187 TYR A CZ  1 
ATOM   1036 O OH  . TYR A 1 187 ? 234.890 304.791 365.277 1.00 14.24 ? 187 TYR A OH  1 
ATOM   1037 N N   . GLY A 1 188 ? 237.996 304.279 360.240 1.00 14.90 ? 188 GLY A N   1 
ATOM   1038 C CA  . GLY A 1 188 ? 237.288 305.046 359.247 1.00 6.35  ? 188 GLY A CA  1 
ATOM   1039 C C   . GLY A 1 188 ? 237.292 304.430 357.867 1.00 7.39  ? 188 GLY A C   1 
ATOM   1040 O O   . GLY A 1 188 ? 236.452 304.794 357.038 1.00 21.96 ? 188 GLY A O   1 
ATOM   1041 N N   . ALA A 1 189 ? 238.210 303.508 357.599 1.00 3.43  ? 189 ALA A N   1 
ATOM   1042 C CA  . ALA A 1 189 ? 238.183 302.764 356.360 1.00 7.17  ? 189 ALA A CA  1 
ATOM   1043 C C   . ALA A 1 189 ? 237.002 301.799 356.370 1.00 3.39  ? 189 ALA A C   1 
ATOM   1044 O O   . ALA A 1 189 ? 236.474 301.464 357.431 1.00 7.82  ? 189 ALA A O   1 
ATOM   1045 C CB  . ALA A 1 189 ? 239.490 301.999 356.169 1.00 5.83  ? 189 ALA A CB  1 
ATOM   1046 N N   . PRO A 1 190 ? 236.563 301.339 355.201 1.00 6.30  ? 190 PRO A N   1 
ATOM   1047 C CA  . PRO A 1 190 ? 235.488 300.356 355.176 1.00 5.60  ? 190 PRO A CA  1 
ATOM   1048 C C   . PRO A 1 190 ? 235.888 299.122 355.957 1.00 6.34  ? 190 PRO A C   1 
ATOM   1049 O O   . PRO A 1 190 ? 237.086 298.800 356.070 1.00 5.24  ? 190 PRO A O   1 
ATOM   1050 C CB  . PRO A 1 190 ? 235.317 300.054 353.680 1.00 4.18  ? 190 PRO A CB  1 
ATOM   1051 C CG  . PRO A 1 190 ? 236.550 300.558 353.023 1.00 10.34 ? 190 PRO A CG  1 
ATOM   1052 C CD  . PRO A 1 190 ? 237.011 301.704 353.848 1.00 4.17  ? 190 PRO A CD  1 
ATOM   1053 N N   . PRO A 1 191 ? 234.922 298.409 356.535 1.00 8.08  ? 191 PRO A N   1 
ATOM   1054 C CA  . PRO A 1 191 ? 235.261 297.260 357.383 1.00 5.28  ? 191 PRO A CA  1 
ATOM   1055 C C   . PRO A 1 191 ? 236.223 296.310 356.684 1.00 8.92  ? 191 PRO A C   1 
ATOM   1056 O O   . PRO A 1 191 ? 236.082 296.017 355.496 1.00 10.92 ? 191 PRO A O   1 
ATOM   1057 C CB  . PRO A 1 191 ? 233.901 296.603 357.639 1.00 4.32  ? 191 PRO A CB  1 
ATOM   1058 C CG  . PRO A 1 191 ? 232.929 297.717 357.536 1.00 11.78 ? 191 PRO A CG  1 
ATOM   1059 C CD  . PRO A 1 191 ? 233.467 298.641 356.482 1.00 7.88  ? 191 PRO A CD  1 
ATOM   1060 N N   . ALA A 1 192 ? 237.217 295.837 357.431 1.00 3.68  ? 192 ALA A N   1 
ATOM   1061 C CA  . ALA A 1 192 ? 238.213 294.945 356.851 1.00 6.27  ? 192 ALA A CA  1 
ATOM   1062 C C   . ALA A 1 192 ? 237.563 293.628 356.448 1.00 1.23  ? 192 ALA A C   1 
ATOM   1063 O O   . ALA A 1 192 ? 236.550 293.221 357.009 1.00 8.28  ? 192 ALA A O   1 
ATOM   1064 C CB  . ALA A 1 192 ? 239.347 294.688 357.842 1.00 3.24  ? 192 ALA A CB  1 
ATOM   1065 N N   . ARG A 1 193 ? 238.138 292.963 355.450 1.00 0.01  ? 193 ARG A N   1 
ATOM   1066 C CA  . ARG A 1 193 ? 237.580 291.692 355.012 1.00 8.77  ? 193 ARG A CA  1 
ATOM   1067 C C   . ARG A 1 193 ? 238.680 290.760 354.533 1.00 2.62  ? 193 ARG A C   1 
ATOM   1068 O O   . ARG A 1 193 ? 239.583 291.171 353.801 1.00 8.02  ? 193 ARG A O   1 
ATOM   1069 C CB  . ARG A 1 193 ? 236.550 291.874 353.892 1.00 7.16  ? 193 ARG A CB  1 
ATOM   1070 C CG  . ARG A 1 193 ? 236.006 290.552 353.357 1.00 7.92  ? 193 ARG A CG  1 
ATOM   1071 C CD  . ARG A 1 193 ? 234.913 290.764 352.329 1.00 7.94  ? 193 ARG A CD  1 
ATOM   1072 N NE  . ARG A 1 193 ? 233.650 291.123 352.958 1.00 5.88  ? 193 ARG A NE  1 
ATOM   1073 C CZ  . ARG A 1 193 ? 232.563 291.503 352.302 1.00 6.25  ? 193 ARG A CZ  1 
ATOM   1074 N NH1 . ARG A 1 193 ? 232.558 291.630 350.985 1.00 10.65 ? 193 ARG A NH1 1 
ATOM   1075 N NH2 . ARG A 1 193 ? 231.454 291.761 352.985 1.00 10.73 ? 193 ARG A NH2 1 
ATOM   1076 N N   . ILE A 1 194 ? 238.572 289.495 354.936 1.00 7.68  ? 194 ILE A N   1 
ATOM   1077 C CA  . ILE A 1 194 ? 239.449 288.438 354.452 1.00 8.96  ? 194 ILE A CA  1 
ATOM   1078 C C   . ILE A 1 194 ? 238.613 287.202 354.158 1.00 7.13  ? 194 ILE A C   1 
ATOM   1079 O O   . ILE A 1 194 ? 237.464 287.079 354.588 1.00 12.27 ? 194 ILE A O   1 
ATOM   1080 C CB  . ILE A 1 194 ? 240.575 288.092 355.452 1.00 8.60  ? 194 ILE A CB  1 
ATOM   1081 C CG1 . ILE A 1 194 ? 239.984 287.638 356.788 1.00 12.82 ? 194 ILE A CG1 1 
ATOM   1082 C CG2 . ILE A 1 194 ? 241.507 289.280 355.644 1.00 9.41  ? 194 ILE A CG2 1 
ATOM   1083 C CD1 . ILE A 1 194 ? 239.870 286.136 356.926 1.00 13.63 ? 194 ILE A CD1 1 
ATOM   1084 N N   . SER A 1 195 ? 239.206 286.283 353.405 1.00 9.94  ? 195 SER A N   1 
ATOM   1085 C CA  . SER A 1 195 ? 238.601 284.993 353.129 1.00 12.43 ? 195 SER A CA  1 
ATOM   1086 C C   . SER A 1 195 ? 239.572 283.886 353.513 1.00 11.99 ? 195 SER A C   1 
ATOM   1087 O O   . SER A 1 195 ? 240.792 284.060 353.474 1.00 13.40 ? 195 SER A O   1 
ATOM   1088 C CB  . SER A 1 195 ? 238.202 284.852 351.653 1.00 9.25  ? 195 SER A CB  1 
ATOM   1089 O OG  . SER A 1 195 ? 239.327 284.956 350.803 1.00 25.83 ? 195 SER A OG  1 
ATOM   1090 N N   . VAL A 1 196 ? 239.007 282.750 353.899 1.00 7.03  ? 196 VAL A N   1 
ATOM   1091 C CA  . VAL A 1 196 ? 239.761 281.554 354.252 1.00 13.93 ? 196 VAL A CA  1 
ATOM   1092 C C   . VAL A 1 196 ? 239.093 280.390 353.533 1.00 8.42  ? 196 VAL A C   1 
ATOM   1093 O O   . VAL A 1 196 ? 237.864 280.389 353.388 1.00 15.83 ? 196 VAL A O   1 
ATOM   1094 C CB  . VAL A 1 196 ? 239.788 281.341 355.774 1.00 11.82 ? 196 VAL A CB  1 
ATOM   1095 C CG1 . VAL A 1 196 ? 240.586 280.106 356.134 1.00 19.18 ? 196 VAL A CG1 1 
ATOM   1096 C CG2 . VAL A 1 196 ? 240.362 282.562 356.469 1.00 18.51 ? 196 VAL A CG2 1 
ATOM   1097 N N   . PRO A 1 197 ? 239.833 279.396 353.063 1.00 14.87 ? 197 PRO A N   1 
ATOM   1098 C CA  . PRO A 1 197 ? 239.204 278.213 352.476 1.00 11.91 ? 197 PRO A CA  1 
ATOM   1099 C C   . PRO A 1 197 ? 238.699 277.292 353.581 1.00 3.88  ? 197 PRO A C   1 
ATOM   1100 O O   . PRO A 1 197 ? 238.766 277.610 354.764 1.00 7.89  ? 197 PRO A O   1 
ATOM   1101 C CB  . PRO A 1 197 ? 240.341 277.576 351.678 1.00 8.15  ? 197 PRO A CB  1 
ATOM   1102 C CG  . PRO A 1 197 ? 241.556 277.945 352.438 1.00 11.55 ? 197 PRO A CG  1 
ATOM   1103 C CD  . PRO A 1 197 ? 241.303 279.323 352.982 1.00 6.47  ? 197 PRO A CD  1 
ATOM   1104 N N   . TYR A 1 198 ? 238.184 276.138 353.175 1.00 9.42  ? 198 TYR A N   1 
ATOM   1105 C CA  . TYR A 1 198 ? 237.858 275.106 354.147 1.00 8.54  ? 198 TYR A CA  1 
ATOM   1106 C C   . TYR A 1 198 ? 239.152 274.583 354.758 1.00 1.79  ? 198 TYR A C   1 
ATOM   1107 O O   . TYR A 1 198 ? 239.989 274.012 354.053 1.00 11.88 ? 198 TYR A O   1 
ATOM   1108 C CB  . TYR A 1 198 ? 237.074 273.970 353.495 1.00 6.03  ? 198 TYR A CB  1 
ATOM   1109 C CG  . TYR A 1 198 ? 236.906 272.801 354.430 1.00 8.03  ? 198 TYR A CG  1 
ATOM   1110 C CD1 . TYR A 1 198 ? 236.011 272.863 355.484 1.00 4.14  ? 198 TYR A CD1 1 
ATOM   1111 C CD2 . TYR A 1 198 ? 237.668 271.651 354.281 1.00 5.76  ? 198 TYR A CD2 1 
ATOM   1112 C CE1 . TYR A 1 198 ? 235.864 271.808 356.357 1.00 7.44  ? 198 TYR A CE1 1 
ATOM   1113 C CE2 . TYR A 1 198 ? 237.528 270.590 355.146 1.00 3.05  ? 198 TYR A CE2 1 
ATOM   1114 C CZ  . TYR A 1 198 ? 236.626 270.672 356.180 1.00 4.88  ? 198 TYR A CZ  1 
ATOM   1115 O OH  . TYR A 1 198 ? 236.497 269.619 357.040 1.00 10.01 ? 198 TYR A OH  1 
ATOM   1116 N N   . VAL A 1 199 ? 239.316 274.772 356.065 1.00 4.60  ? 199 VAL A N   1 
ATOM   1117 C CA  . VAL A 1 199 ? 240.565 274.458 356.748 1.00 9.17  ? 199 VAL A CA  1 
ATOM   1118 C C   . VAL A 1 199 ? 240.403 273.315 357.741 1.00 7.45  ? 199 VAL A C   1 
ATOM   1119 O O   . VAL A 1 199 ? 241.306 273.070 358.546 1.00 16.62 ? 199 VAL A O   1 
ATOM   1120 C CB  . VAL A 1 199 ? 241.146 275.698 357.447 1.00 11.35 ? 199 VAL A CB  1 
ATOM   1121 C CG1 . VAL A 1 199 ? 241.530 276.755 356.427 1.00 7.67  ? 199 VAL A CG1 1 
ATOM   1122 C CG2 . VAL A 1 199 ? 240.158 276.256 358.458 1.00 9.66  ? 199 VAL A CG2 1 
ATOM   1123 N N   . GLY A 1 200 ? 239.274 272.614 357.713 1.00 6.51  ? 200 GLY A N   1 
ATOM   1124 C CA  . GLY A 1 200 ? 239.088 271.511 358.639 1.00 3.42  ? 200 GLY A CA  1 
ATOM   1125 C C   . GLY A 1 200 ? 240.115 270.414 358.408 1.00 3.53  ? 200 GLY A C   1 
ATOM   1126 O O   . GLY A 1 200 ? 240.446 270.074 357.271 1.00 9.25  ? 200 GLY A O   1 
ATOM   1127 N N   . ILE A 1 201 ? 240.629 269.860 359.510 1.00 4.68  ? 201 ILE A N   1 
ATOM   1128 C CA  . ILE A 1 201 ? 241.503 268.697 359.414 1.00 8.30  ? 201 ILE A CA  1 
ATOM   1129 C C   . ILE A 1 201 ? 240.716 267.447 359.044 1.00 9.41  ? 201 ILE A C   1 
ATOM   1130 O O   . ILE A 1 201 ? 241.305 266.461 358.590 1.00 11.99 ? 201 ILE A O   1 
ATOM   1131 C CB  . ILE A 1 201 ? 242.279 268.480 360.728 1.00 8.93  ? 201 ILE A CB  1 
ATOM   1132 C CG1 . ILE A 1 201 ? 241.318 268.165 361.880 1.00 10.49 ? 201 ILE A CG1 1 
ATOM   1133 C CG2 . ILE A 1 201 ? 243.139 269.699 361.045 1.00 6.16  ? 201 ILE A CG2 1 
ATOM   1134 C CD1 . ILE A 1 201 ? 241.997 268.013 363.221 1.00 8.67  ? 201 ILE A CD1 1 
ATOM   1135 N N   . ALA A 1 202 ? 239.402 267.456 359.242 1.00 8.79  ? 202 ALA A N   1 
ATOM   1136 C CA  . ALA A 1 202 ? 238.535 266.404 358.740 1.00 8.15  ? 202 ALA A CA  1 
ATOM   1137 C C   . ALA A 1 202 ? 237.999 266.789 357.363 1.00 0.70  ? 202 ALA A C   1 
ATOM   1138 O O   . ALA A 1 202 ? 238.209 267.899 356.874 1.00 6.16  ? 202 ALA A O   1 
ATOM   1139 C CB  . ALA A 1 202 ? 237.384 266.145 359.711 1.00 7.05  ? 202 ALA A CB  1 
ATOM   1140 N N   . ASN A 1 203 ? 237.293 265.851 356.735 1.00 7.69  ? 203 ASN A N   1 
ATOM   1141 C CA  . ASN A 1 203 ? 236.702 266.111 355.428 1.00 4.54  ? 203 ASN A CA  1 
ATOM   1142 C C   . ASN A 1 203 ? 235.473 267.009 355.509 1.00 2.59  ? 203 ASN A C   1 
ATOM   1143 O O   . ASN A 1 203 ? 234.968 267.433 354.467 1.00 3.10  ? 203 ASN A O   1 
ATOM   1144 C CB  . ASN A 1 203 ? 236.350 264.790 354.749 1.00 4.66  ? 203 ASN A CB  1 
ATOM   1145 C CG  . ASN A 1 203 ? 237.546 263.863 354.630 1.00 7.86  ? 203 ASN A CG  1 
ATOM   1146 O OD1 . ASN A 1 203 ? 237.836 263.091 355.539 1.00 15.89 ? 203 ASN A OD1 1 
ATOM   1147 N ND2 . ASN A 1 203 ? 238.246 263.940 353.508 1.00 11.02 ? 203 ASN A ND2 1 
ATOM   1148 N N   . ALA A 1 204 ? 234.976 267.288 356.710 1.00 0.01  ? 204 ALA A N   1 
ATOM   1149 C CA  . ALA A 1 204 ? 233.937 268.286 356.908 1.00 3.93  ? 204 ALA A CA  1 
ATOM   1150 C C   . ALA A 1 204 ? 234.030 268.786 358.340 1.00 0.01  ? 204 ALA A C   1 
ATOM   1151 O O   . ALA A 1 204 ? 234.546 268.096 359.222 1.00 14.89 ? 204 ALA A O   1 
ATOM   1152 C CB  . ALA A 1 204 ? 232.542 267.720 356.620 1.00 4.50  ? 204 ALA A CB  1 
ATOM   1153 N N   . TYR A 1 205 ? 233.530 269.997 358.559 1.00 0.01  ? 205 TYR A N   1 
ATOM   1154 C CA  . TYR A 1 205 ? 233.348 270.477 359.918 1.00 5.75  ? 205 TYR A CA  1 
ATOM   1155 C C   . TYR A 1 205 ? 232.265 269.656 360.607 1.00 5.05  ? 205 TYR A C   1 
ATOM   1156 O O   . TYR A 1 205 ? 231.297 269.217 359.984 1.00 5.46  ? 205 TYR A O   1 
ATOM   1157 C CB  . TYR A 1 205 ? 232.958 271.955 359.935 1.00 7.91  ? 205 TYR A CB  1 
ATOM   1158 C CG  . TYR A 1 205 ? 233.965 272.904 359.321 1.00 11.95 ? 205 TYR A CG  1 
ATOM   1159 C CD1 . TYR A 1 205 ? 235.264 272.988 359.808 1.00 9.40  ? 205 TYR A CD1 1 
ATOM   1160 C CD2 . TYR A 1 205 ? 233.605 273.736 358.270 1.00 6.14  ? 205 TYR A CD2 1 
ATOM   1161 C CE1 . TYR A 1 205 ? 236.176 273.863 359.255 1.00 10.24 ? 205 TYR A CE1 1 
ATOM   1162 C CE2 . TYR A 1 205 ? 234.508 274.622 357.718 1.00 10.98 ? 205 TYR A CE2 1 
ATOM   1163 C CZ  . TYR A 1 205 ? 235.794 274.678 358.211 1.00 10.96 ? 205 TYR A CZ  1 
ATOM   1164 O OH  . TYR A 1 205 ? 236.699 275.548 357.661 1.00 15.62 ? 205 TYR A OH  1 
ATOM   1165 N N   . SER A 1 206 ? 232.441 269.436 361.903 1.00 6.46  ? 206 SER A N   1 
ATOM   1166 C CA  . SER A 1 206 ? 231.480 268.693 362.710 1.00 8.58  ? 206 SER A CA  1 
ATOM   1167 C C   . SER A 1 206 ? 230.775 269.673 363.637 1.00 5.17  ? 206 SER A C   1 
ATOM   1168 O O   . SER A 1 206 ? 231.394 270.230 364.548 1.00 14.29 ? 206 SER A O   1 
ATOM   1169 C CB  . SER A 1 206 ? 232.162 267.581 363.503 1.00 3.56  ? 206 SER A CB  1 
ATOM   1170 O OG  . SER A 1 206 ? 232.450 266.474 362.673 1.00 19.85 ? 206 SER A OG  1 
ATOM   1171 N N   . HIS A 1 207 ? 229.480 269.881 363.399 1.00 8.59  ? 207 HIS A N   1 
ATOM   1172 C CA  . HIS A 1 207 ? 228.690 270.709 364.301 1.00 6.02  ? 207 HIS A CA  1 
ATOM   1173 C C   . HIS A 1 207 ? 228.354 269.960 365.580 1.00 2.64  ? 207 HIS A C   1 
ATOM   1174 O O   . HIS A 1 207 ? 228.174 270.580 366.633 1.00 6.55  ? 207 HIS A O   1 
ATOM   1175 C CB  . HIS A 1 207 ? 227.416 271.173 363.601 1.00 4.28  ? 207 HIS A CB  1 
ATOM   1176 C CG  . HIS A 1 207 ? 227.669 271.943 362.345 1.00 10.06 ? 207 HIS A CG  1 
ATOM   1177 N ND1 . HIS A 1 207 ? 226.682 272.204 361.419 1.00 11.34 ? 207 HIS A ND1 1 
ATOM   1178 C CD2 . HIS A 1 207 ? 228.799 272.510 361.860 1.00 6.25  ? 207 HIS A CD2 1 
ATOM   1179 C CE1 . HIS A 1 207 ? 227.193 272.898 360.419 1.00 9.84  ? 207 HIS A CE1 1 
ATOM   1180 N NE2 . HIS A 1 207 ? 228.476 273.094 360.661 1.00 11.92 ? 207 HIS A NE2 1 
ATOM   1181 N N   . PHE A 1 208 ? 228.268 268.636 365.505 1.00 8.96  ? 208 PHE A N   1 
ATOM   1182 C CA  . PHE A 1 208 ? 228.030 267.787 366.660 1.00 8.80  ? 208 PHE A CA  1 
ATOM   1183 C C   . PHE A 1 208 ? 229.032 266.645 366.625 1.00 3.54  ? 208 PHE A C   1 
ATOM   1184 O O   . PHE A 1 208 ? 229.220 266.012 365.581 1.00 13.32 ? 208 PHE A O   1 
ATOM   1185 C CB  . PHE A 1 208 ? 226.590 267.255 366.664 1.00 2.70  ? 208 PHE A CB  1 
ATOM   1186 C CG  . PHE A 1 208 ? 225.549 268.339 366.643 1.00 2.86  ? 208 PHE A CG  1 
ATOM   1187 C CD1 . PHE A 1 208 ? 225.198 268.960 365.456 1.00 0.01  ? 208 PHE A CD1 1 
ATOM   1188 C CD2 . PHE A 1 208 ? 224.930 268.746 367.813 1.00 4.59  ? 208 PHE A CD2 1 
ATOM   1189 C CE1 . PHE A 1 208 ? 224.251 269.966 365.438 1.00 4.48  ? 208 PHE A CE1 1 
ATOM   1190 C CE2 . PHE A 1 208 ? 223.980 269.747 367.799 1.00 6.83  ? 208 PHE A CE2 1 
ATOM   1191 C CZ  . PHE A 1 208 ? 223.638 270.357 366.610 1.00 6.41  ? 208 PHE A CZ  1 
ATOM   1192 N N   . TYR A 1 209 ? 229.687 266.401 367.754 1.00 7.77  ? 209 TYR A N   1 
ATOM   1193 C CA  . TYR A 1 209 ? 230.662 265.322 367.889 1.00 5.52  ? 209 TYR A CA  1 
ATOM   1194 C C   . TYR A 1 209 ? 230.248 264.491 369.098 1.00 3.53  ? 209 TYR A C   1 
ATOM   1195 O O   . TYR A 1 209 ? 230.433 264.914 370.240 1.00 9.29  ? 209 TYR A O   1 
ATOM   1196 C CB  . TYR A 1 209 ? 232.079 265.870 368.038 1.00 2.56  ? 209 TYR A CB  1 
ATOM   1197 C CG  . TYR A 1 209 ? 233.105 264.820 368.394 1.00 7.40  ? 209 TYR A CG  1 
ATOM   1198 C CD1 . TYR A 1 209 ? 233.562 263.920 367.442 1.00 7.31  ? 209 TYR A CD1 1 
ATOM   1199 C CD2 . TYR A 1 209 ? 233.611 264.726 369.682 1.00 7.76  ? 209 TYR A CD2 1 
ATOM   1200 C CE1 . TYR A 1 209 ? 234.496 262.959 367.763 1.00 7.74  ? 209 TYR A CE1 1 
ATOM   1201 C CE2 . TYR A 1 209 ? 234.545 263.769 370.012 1.00 7.98  ? 209 TYR A CE2 1 
ATOM   1202 C CZ  . TYR A 1 209 ? 234.982 262.887 369.051 1.00 8.87  ? 209 TYR A CZ  1 
ATOM   1203 O OH  . TYR A 1 209 ? 235.913 261.931 369.376 1.00 14.98 ? 209 TYR A OH  1 
ATOM   1204 N N   . ASP A 1 210 ? 229.682 263.313 368.848 1.00 4.35  ? 210 ASP A N   1 
ATOM   1205 C CA  . ASP A 1 210 ? 229.188 262.452 369.923 1.00 8.41  ? 210 ASP A CA  1 
ATOM   1206 C C   . ASP A 1 210 ? 230.323 261.555 370.420 1.00 11.66 ? 210 ASP A C   1 
ATOM   1207 O O   . ASP A 1 210 ? 230.365 260.348 370.180 1.00 11.08 ? 210 ASP A O   1 
ATOM   1208 C CB  . ASP A 1 210 ? 227.996 261.636 369.442 1.00 9.17  ? 210 ASP A CB  1 
ATOM   1209 C CG  . ASP A 1 210 ? 227.393 260.784 370.540 1.00 11.70 ? 210 ASP A CG  1 
ATOM   1210 O OD1 . ASP A 1 210 ? 227.600 261.105 371.728 1.00 13.44 ? 210 ASP A OD1 1 
ATOM   1211 O OD2 . ASP A 1 210 ? 226.714 259.790 370.216 1.00 12.60 ? 210 ASP A OD2 1 
ATOM   1212 N N   . GLY A 1 211 ? 231.254 262.176 371.132 1.00 5.77  ? 211 GLY A N   1 
ATOM   1213 C CA  . GLY A 1 211 ? 232.400 261.438 371.618 1.00 11.21 ? 211 GLY A CA  1 
ATOM   1214 C C   . GLY A 1 211 ? 233.286 262.280 372.508 1.00 5.06  ? 211 GLY A C   1 
ATOM   1215 O O   . GLY A 1 211 ? 232.909 263.366 372.950 1.00 9.76  ? 211 GLY A O   1 
ATOM   1216 N N   . PHE A 1 212 ? 234.481 261.754 372.757 1.00 14.50 ? 212 PHE A N   1 
ATOM   1217 C CA  . PHE A 1 212 ? 235.469 262.389 373.615 1.00 9.39  ? 212 PHE A CA  1 
ATOM   1218 C C   . PHE A 1 212 ? 236.800 262.468 372.884 1.00 7.89  ? 212 PHE A C   1 
ATOM   1219 O O   . PHE A 1 212 ? 237.067 261.709 371.950 1.00 16.00 ? 212 PHE A O   1 
ATOM   1220 C CB  . PHE A 1 212 ? 235.652 261.620 374.931 1.00 11.14 ? 212 PHE A CB  1 
ATOM   1221 C CG  . PHE A 1 212 ? 234.416 261.561 375.774 1.00 13.03 ? 212 PHE A CG  1 
ATOM   1222 C CD1 . PHE A 1 212 ? 233.396 260.674 375.470 1.00 9.73  ? 212 PHE A CD1 1 
ATOM   1223 C CD2 . PHE A 1 212 ? 234.271 262.392 376.871 1.00 10.62 ? 212 PHE A CD2 1 
ATOM   1224 C CE1 . PHE A 1 212 ? 232.259 260.620 376.243 1.00 10.07 ? 212 PHE A CE1 1 
ATOM   1225 C CE2 . PHE A 1 212 ? 233.134 262.339 377.650 1.00 13.71 ? 212 PHE A CE2 1 
ATOM   1226 C CZ  . PHE A 1 212 ? 232.126 261.453 377.334 1.00 12.54 ? 212 PHE A CZ  1 
ATOM   1227 N N   . ALA A 1 213 ? 237.633 263.412 373.317 1.00 15.06 ? 213 ALA A N   1 
ATOM   1228 C CA  . ALA A 1 213 ? 238.995 263.487 372.805 1.00 16.40 ? 213 ALA A CA  1 
ATOM   1229 C C   . ALA A 1 213 ? 239.885 262.414 373.417 1.00 11.73 ? 213 ALA A C   1 
ATOM   1230 O O   . ALA A 1 213 ? 240.824 261.950 372.764 1.00 18.67 ? 213 ALA A O   1 
ATOM   1231 C CB  . ALA A 1 213 ? 239.583 264.873 373.070 1.00 8.35  ? 213 ALA A CB  1 
ATOM   1232 N N   . LYS A 1 214 ? 239.612 262.020 374.658 1.00 15.65 ? 214 LYS A N   1 
ATOM   1233 C CA  . LYS A 1 214 ? 240.336 260.962 375.346 1.00 18.03 ? 214 LYS A CA  1 
ATOM   1234 C C   . LYS A 1 214 ? 239.372 259.857 375.748 1.00 13.52 ? 214 LYS A C   1 
ATOM   1235 O O   . LYS A 1 214 ? 238.217 260.116 376.094 1.00 23.83 ? 214 LYS A O   1 
ATOM   1236 C CB  . LYS A 1 214 ? 241.030 261.469 376.617 1.00 16.79 ? 214 LYS A CB  1 
ATOM   1237 C CG  . LYS A 1 214 ? 242.030 262.583 376.432 1.00 19.40 ? 214 LYS A CG  1 
ATOM   1238 C CD  . LYS A 1 214 ? 242.474 263.103 377.794 1.00 22.85 ? 214 LYS A CD  1 
ATOM   1239 C CE  . LYS A 1 214 ? 243.481 264.231 377.679 1.00 20.42 ? 214 LYS A CE  1 
ATOM   1240 N NZ  . LYS A 1 214 ? 243.801 264.818 379.005 1.00 27.60 ? 214 LYS A NZ  1 
ATOM   1241 N N   . VAL A 1 215 ? 239.857 258.623 375.712 1.00 16.62 ? 215 VAL A N   1 
ATOM   1242 C CA  . VAL A 1 215 ? 239.175 257.491 376.331 1.00 18.24 ? 215 VAL A CA  1 
ATOM   1243 C C   . VAL A 1 215 ? 239.883 257.201 377.650 1.00 14.86 ? 215 VAL A C   1 
ATOM   1244 O O   . VAL A 1 215 ? 241.070 256.848 377.632 1.00 20.08 ? 215 VAL A O   1 
ATOM   1245 C CB  . VAL A 1 215 ? 239.175 256.252 375.425 1.00 14.56 ? 215 VAL A CB  1 
ATOM   1246 C CG1 . VAL A 1 215 ? 238.496 255.081 376.127 1.00 15.08 ? 215 VAL A CG1 1 
ATOM   1247 C CG2 . VAL A 1 215 ? 238.489 256.557 374.109 1.00 17.27 ? 215 VAL A CG2 1 
ATOM   1248 N N   . PRO A 1 216 ? 239.222 257.348 378.797 1.00 17.91 ? 216 PRO A N   1 
ATOM   1249 C CA  . PRO A 1 216 ? 239.870 256.961 380.053 1.00 17.82 ? 216 PRO A CA  1 
ATOM   1250 C C   . PRO A 1 216 ? 240.164 255.470 380.051 1.00 12.47 ? 216 PRO A C   1 
ATOM   1251 O O   . PRO A 1 216 ? 239.386 254.668 379.530 1.00 20.34 ? 216 PRO A O   1 
ATOM   1252 C CB  . PRO A 1 216 ? 238.840 257.342 381.120 1.00 18.88 ? 216 PRO A CB  1 
ATOM   1253 C CG  . PRO A 1 216 ? 237.538 257.275 380.418 1.00 17.75 ? 216 PRO A CG  1 
ATOM   1254 C CD  . PRO A 1 216 ? 237.802 257.685 378.996 1.00 10.45 ? 216 PRO A CD  1 
ATOM   1255 N N   . LEU A 1 217 ? 241.300 255.101 380.627 1.00 20.46 ? 217 LEU A N   1 
ATOM   1256 C CA  . LEU A 1 217 ? 241.745 253.717 380.651 1.00 18.29 ? 217 LEU A CA  1 
ATOM   1257 C C   . LEU A 1 217 ? 241.735 253.194 382.079 1.00 21.18 ? 217 LEU A C   1 
ATOM   1258 O O   . LEU A 1 217 ? 241.941 253.946 383.035 1.00 22.12 ? 217 LEU A O   1 
ATOM   1259 C CB  . LEU A 1 217 ? 243.148 253.578 380.053 1.00 17.67 ? 217 LEU A CB  1 
ATOM   1260 C CG  . LEU A 1 217 ? 243.329 254.157 378.648 1.00 18.06 ? 217 LEU A CG  1 
ATOM   1261 C CD1 . LEU A 1 217 ? 244.764 253.980 378.181 1.00 18.70 ? 217 LEU A CD1 1 
ATOM   1262 C CD2 . LEU A 1 217 ? 242.360 253.522 377.659 1.00 16.23 ? 217 LEU A CD2 1 
ATOM   1263 N N   . ALA A 1 218 ? 241.487 251.894 382.213 1.00 21.51 ? 218 ALA A N   1 
ATOM   1264 C CA  . ALA A 1 218 ? 241.475 251.273 383.529 1.00 23.80 ? 218 ALA A CA  1 
ATOM   1265 C C   . ALA A 1 218 ? 242.832 251.437 384.199 1.00 23.29 ? 218 ALA A C   1 
ATOM   1266 O O   . ALA A 1 218 ? 243.880 251.332 383.557 1.00 26.87 ? 218 ALA A O   1 
ATOM   1267 C CB  . ALA A 1 218 ? 241.115 249.792 383.414 1.00 23.81 ? 218 ALA A CB  1 
ATOM   1268 N N   . GLY A 1 219 ? 242.807 251.706 385.502 1.00 28.23 ? 219 GLY A N   1 
ATOM   1269 C CA  . GLY A 1 219 ? 244.013 251.952 386.258 1.00 26.55 ? 219 GLY A CA  1 
ATOM   1270 C C   . GLY A 1 219 ? 244.454 253.399 386.294 1.00 30.92 ? 219 GLY A C   1 
ATOM   1271 O O   . GLY A 1 219 ? 245.342 253.738 387.085 1.00 35.67 ? 219 GLY A O   1 
ATOM   1272 N N   . GLN A 1 220 ? 243.867 254.260 385.467 1.00 30.61 ? 220 GLN A N   1 
ATOM   1273 C CA  . GLN A 1 220 ? 244.152 255.685 385.529 1.00 30.84 ? 220 GLN A CA  1 
ATOM   1274 C C   . GLN A 1 220 ? 243.295 256.339 386.604 1.00 30.39 ? 220 GLN A C   1 
ATOM   1275 O O   . GLN A 1 220 ? 242.123 255.995 386.780 1.00 32.59 ? 220 GLN A O   1 
ATOM   1276 C CB  . GLN A 1 220 ? 243.887 256.349 384.177 1.00 27.48 ? 220 GLN A CB  1 
ATOM   1277 C CG  . GLN A 1 220 ? 244.842 255.926 383.073 1.00 27.51 ? 220 GLN A CG  1 
ATOM   1278 C CD  . GLN A 1 220 ? 244.556 256.624 381.757 1.00 29.79 ? 220 GLN A CD  1 
ATOM   1279 O OE1 . GLN A 1 220 ? 243.537 257.297 381.605 1.00 28.83 ? 220 GLN A OE1 1 
ATOM   1280 N NE2 . GLN A 1 220 ? 245.461 256.470 380.797 1.00 32.77 ? 220 GLN A NE2 1 
ATOM   1281 N N   . ALA A 1 221 ? 243.888 257.286 387.326 1.00 34.82 ? 221 ALA A N   1 
ATOM   1282 C CA  . ALA A 1 221 ? 243.153 258.011 388.348 1.00 33.24 ? 221 ALA A CA  1 
ATOM   1283 C C   . ALA A 1 221 ? 241.996 258.785 387.718 1.00 34.40 ? 221 ALA A C   1 
ATOM   1284 O O   . ALA A 1 221 ? 241.883 258.913 386.497 1.00 36.64 ? 221 ALA A O   1 
ATOM   1285 C CB  . ALA A 1 221 ? 244.083 258.962 389.099 1.00 33.18 ? 221 ALA A CB  1 
ATOM   1286 N N   . SER A 1 222 ? 241.125 259.312 388.580 1.00 34.06 ? 222 SER A N   1 
ATOM   1287 C CA  . SER A 1 222 ? 239.959 260.044 388.095 1.00 34.51 ? 222 SER A CA  1 
ATOM   1288 C C   . SER A 1 222 ? 240.373 261.262 387.279 1.00 35.82 ? 222 SER A C   1 
ATOM   1289 O O   . SER A 1 222 ? 239.769 261.558 386.241 1.00 35.61 ? 222 SER A O   1 
ATOM   1290 C CB  . SER A 1 222 ? 239.080 260.465 389.271 1.00 36.58 ? 222 SER A CB  1 
ATOM   1291 O OG  . SER A 1 222 ? 238.718 259.348 390.064 1.00 37.66 ? 222 SER A OG  1 
ATOM   1292 N N   . THR A 1 223 ? 241.402 261.982 387.734 1.00 32.21 ? 223 THR A N   1 
ATOM   1293 C CA  . THR A 1 223 ? 241.828 263.191 387.037 1.00 34.77 ? 223 THR A CA  1 
ATOM   1294 C C   . THR A 1 223 ? 242.331 262.889 385.631 1.00 36.93 ? 223 THR A C   1 
ATOM   1295 O O   . THR A 1 223 ? 242.219 263.738 384.739 1.00 35.73 ? 223 THR A O   1 
ATOM   1296 C CB  . THR A 1 223 ? 242.920 263.902 387.838 1.00 35.24 ? 223 THR A CB  1 
ATOM   1297 O OG1 . THR A 1 223 ? 243.987 262.986 388.117 1.00 38.07 ? 223 THR A OG1 1 
ATOM   1298 C CG2 . THR A 1 223 ? 242.360 264.442 389.144 1.00 36.71 ? 223 THR A CG2 1 
ATOM   1299 N N   . GLU A 1 224 ? 242.889 261.704 385.413 1.00 33.52 ? 224 GLU A N   1 
ATOM   1300 C CA  . GLU A 1 224 ? 243.449 261.347 384.119 1.00 31.85 ? 224 GLU A CA  1 
ATOM   1301 C C   . GLU A 1 224 ? 242.382 260.725 383.226 1.00 30.60 ? 224 GLU A C   1 
ATOM   1302 O O   . GLU A 1 224 ? 241.472 260.038 383.696 1.00 32.00 ? 224 GLU A O   1 
ATOM   1303 C CB  . GLU A 1 224 ? 244.618 260.375 384.290 1.00 32.33 ? 224 GLU A CB  1 
ATOM   1304 C CG  . GLU A 1 224 ? 245.685 260.864 385.259 1.00 33.58 ? 224 GLU A CG  1 
ATOM   1305 C CD  . GLU A 1 224 ? 246.257 262.213 384.869 1.00 37.17 ? 224 GLU A CD  1 
ATOM   1306 O OE1 . GLU A 1 224 ? 246.403 262.472 383.656 1.00 38.27 ? 224 GLU A OE1 1 
ATOM   1307 O OE2 . GLU A 1 224 ? 246.554 263.020 385.776 1.00 38.12 ? 224 GLU A OE2 1 
ATOM   1308 N N   . GLY A 1 225 ? 242.503 260.982 381.927 1.00 28.38 ? 225 GLY A N   1 
ATOM   1309 C CA  . GLY A 1 225 ? 241.566 260.455 380.957 1.00 23.08 ? 225 GLY A CA  1 
ATOM   1310 C C   . GLY A 1 225 ? 240.243 261.179 380.887 1.00 23.79 ? 225 GLY A C   1 
ATOM   1311 O O   . GLY A 1 225 ? 239.360 260.747 380.139 1.00 28.11 ? 225 GLY A O   1 
ATOM   1312 N N   . ASP A 1 226 ? 240.075 262.266 381.634 1.00 26.52 ? 226 ASP A N   1 
ATOM   1313 C CA  . ASP A 1 226 ? 238.825 263.013 381.654 1.00 24.03 ? 226 ASP A CA  1 
ATOM   1314 C C   . ASP A 1 226 ? 238.898 264.136 380.626 1.00 20.94 ? 226 ASP A C   1 
ATOM   1315 O O   . ASP A 1 226 ? 239.806 264.971 380.675 1.00 28.55 ? 226 ASP A O   1 
ATOM   1316 C CB  . ASP A 1 226 ? 238.557 263.576 383.049 1.00 24.88 ? 226 ASP A CB  1 
ATOM   1317 C CG  . ASP A 1 226 ? 237.239 264.323 383.137 1.00 29.45 ? 226 ASP A CG  1 
ATOM   1318 O OD1 . ASP A 1 226 ? 236.453 264.274 382.169 1.00 26.01 ? 226 ASP A OD1 1 
ATOM   1319 O OD2 . ASP A 1 226 ? 236.990 264.964 384.179 1.00 32.17 ? 226 ASP A OD2 1 
ATOM   1320 N N   . SER A 1 227 ? 237.948 264.147 379.696 1.00 18.87 ? 227 SER A N   1 
ATOM   1321 C CA  . SER A 1 227 ? 237.828 265.216 378.718 1.00 15.45 ? 227 SER A CA  1 
ATOM   1322 C C   . SER A 1 227 ? 236.358 265.576 378.574 1.00 11.59 ? 227 SER A C   1 
ATOM   1323 O O   . SER A 1 227 ? 235.470 264.772 378.867 1.00 19.95 ? 227 SER A O   1 
ATOM   1324 C CB  . SER A 1 227 ? 238.422 264.818 377.360 1.00 15.57 ? 227 SER A CB  1 
ATOM   1325 O OG  . SER A 1 227 ? 237.721 263.727 376.792 1.00 22.49 ? 227 SER A OG  1 
ATOM   1326 N N   . LEU A 1 228 ? 236.107 266.804 378.130 1.00 14.30 ? 228 LEU A N   1 
ATOM   1327 C CA  . LEU A 1 228 ? 234.736 267.278 378.006 1.00 16.63 ? 228 LEU A CA  1 
ATOM   1328 C C   . LEU A 1 228 ? 233.986 266.476 376.950 1.00 12.74 ? 228 LEU A C   1 
ATOM   1329 O O   . LEU A 1 228 ? 234.532 266.134 375.899 1.00 11.24 ? 228 LEU A O   1 
ATOM   1330 C CB  . LEU A 1 228 ? 234.718 268.764 377.650 1.00 16.67 ? 228 LEU A CB  1 
ATOM   1331 C CG  . LEU A 1 228 ? 235.314 269.722 378.684 1.00 12.66 ? 228 LEU A CG  1 
ATOM   1332 C CD1 . LEU A 1 228 ? 235.203 271.157 378.198 1.00 16.17 ? 228 LEU A CD1 1 
ATOM   1333 C CD2 . LEU A 1 228 ? 234.637 269.562 380.032 1.00 17.64 ? 228 LEU A CD2 1 
ATOM   1334 N N   . TYR A 1 229 ? 232.723 266.176 377.239 1.00 15.16 ? 229 TYR A N   1 
ATOM   1335 C CA  . TYR A 1 229 ? 231.887 265.455 376.290 1.00 7.68  ? 229 TYR A CA  1 
ATOM   1336 C C   . TYR A 1 229 ? 231.570 266.340 375.091 1.00 7.94  ? 229 TYR A C   1 
ATOM   1337 O O   . TYR A 1 229 ? 231.117 267.476 375.244 1.00 19.82 ? 229 TYR A O   1 
ATOM   1338 C CB  . TYR A 1 229 ? 230.598 264.996 376.968 1.00 10.69 ? 229 TYR A CB  1 
ATOM   1339 C CG  . TYR A 1 229 ? 229.582 264.399 376.020 1.00 14.64 ? 229 TYR A CG  1 
ATOM   1340 C CD1 . TYR A 1 229 ? 229.779 263.144 375.461 1.00 9.98  ? 229 TYR A CD1 1 
ATOM   1341 C CD2 . TYR A 1 229 ? 228.419 265.087 375.695 1.00 8.00  ? 229 TYR A CD2 1 
ATOM   1342 C CE1 . TYR A 1 229 ? 228.852 262.593 374.600 1.00 8.35  ? 229 TYR A CE1 1 
ATOM   1343 C CE2 . TYR A 1 229 ? 227.486 264.543 374.834 1.00 11.20 ? 229 TYR A CE2 1 
ATOM   1344 C CZ  . TYR A 1 229 ? 227.707 263.296 374.290 1.00 10.23 ? 229 TYR A CZ  1 
ATOM   1345 O OH  . TYR A 1 229 ? 226.784 262.750 373.433 1.00 12.97 ? 229 TYR A OH  1 
ATOM   1346 N N   . GLY A 1 230 ? 231.810 265.813 373.896 1.00 9.44  ? 230 GLY A N   1 
ATOM   1347 C CA  . GLY A 1 230 ? 231.560 266.553 372.680 1.00 11.63 ? 230 GLY A CA  1 
ATOM   1348 C C   . GLY A 1 230 ? 232.646 267.520 372.273 1.00 10.97 ? 230 GLY A C   1 
ATOM   1349 O O   . GLY A 1 230 ? 232.457 268.258 371.302 1.00 18.82 ? 230 GLY A O   1 
ATOM   1350 N N   . ALA A 1 231 ? 233.773 267.544 372.979 1.00 13.42 ? 231 ALA A N   1 
ATOM   1351 C CA  . ALA A 1 231 ? 234.873 268.449 372.674 1.00 14.24 ? 231 ALA A CA  1 
ATOM   1352 C C   . ALA A 1 231 ? 235.958 267.687 371.922 1.00 16.44 ? 231 ALA A C   1 
ATOM   1353 O O   . ALA A 1 231 ? 236.531 266.729 372.451 1.00 22.87 ? 231 ALA A O   1 
ATOM   1354 C CB  . ALA A 1 231 ? 235.443 269.065 373.951 1.00 13.73 ? 231 ALA A CB  1 
ATOM   1355 N N   . ALA A 1 232 ? 236.236 268.114 370.695 1.00 10.13 ? 232 ALA A N   1 
ATOM   1356 C CA  . ALA A 1 232 ? 237.310 267.546 369.898 1.00 13.73 ? 232 ALA A CA  1 
ATOM   1357 C C   . ALA A 1 232 ? 238.048 268.677 369.200 1.00 15.74 ? 232 ALA A C   1 
ATOM   1358 O O   . ALA A 1 232 ? 237.504 269.764 368.991 1.00 23.58 ? 232 ALA A O   1 
ATOM   1359 C CB  . ALA A 1 232 ? 236.784 266.536 368.869 1.00 15.26 ? 232 ALA A CB  1 
ATOM   1360 N N   . SER A 1 233 ? 239.300 268.408 368.835 1.00 11.92 ? 233 SER A N   1 
ATOM   1361 C CA  . SER A 1 233 ? 240.097 269.393 368.115 1.00 14.49 ? 233 SER A CA  1 
ATOM   1362 C C   . SER A 1 233 ? 239.619 269.601 366.684 1.00 10.72 ? 233 SER A C   1 
ATOM   1363 O O   . SER A 1 233 ? 240.228 270.390 365.957 1.00 16.60 ? 233 SER A O   1 
ATOM   1364 C CB  . SER A 1 233 ? 241.568 268.977 368.118 1.00 13.93 ? 233 SER A CB  1 
ATOM   1365 O OG  . SER A 1 233 ? 241.771 267.800 367.361 1.00 20.94 ? 233 SER A OG  1 
ATOM   1366 N N   . LEU A 1 234 ? 238.546 268.920 366.269 1.00 14.68 ? 234 LEU A N   1 
ATOM   1367 C CA  . LEU A 1 234 ? 237.971 269.139 364.948 1.00 14.71 ? 234 LEU A CA  1 
ATOM   1368 C C   . LEU A 1 234 ? 237.527 270.580 364.744 1.00 12.83 ? 234 LEU A C   1 
ATOM   1369 O O   . LEU A 1 234 ? 237.391 271.017 363.597 1.00 20.33 ? 234 LEU A O   1 
ATOM   1370 C CB  . LEU A 1 234 ? 236.775 268.207 364.736 1.00 14.82 ? 234 LEU A CB  1 
ATOM   1371 C CG  . LEU A 1 234 ? 237.059 266.705 364.746 1.00 15.08 ? 234 LEU A CG  1 
ATOM   1372 C CD1 . LEU A 1 234 ? 235.761 265.909 364.777 1.00 14.38 ? 234 LEU A CD1 1 
ATOM   1373 C CD2 . LEU A 1 234 ? 237.894 266.321 363.540 1.00 16.91 ? 234 LEU A CD2 1 
ATOM   1374 N N   . ASN A 1 235 ? 237.285 271.324 365.826 1.00 13.79 ? 235 ASN A N   1 
ATOM   1375 C CA  . ASN A 1 235 ? 236.878 272.721 365.736 1.00 20.73 ? 235 ASN A CA  1 
ATOM   1376 C C   . ASN A 1 235 ? 237.900 273.658 366.371 1.00 15.15 ? 235 ASN A C   1 
ATOM   1377 O O   . ASN A 1 235 ? 237.557 274.786 366.736 1.00 22.72 ? 235 ASN A O   1 
ATOM   1378 C CB  . ASN A 1 235 ? 235.503 272.920 366.377 1.00 18.06 ? 235 ASN A CB  1 
ATOM   1379 C CG  . ASN A 1 235 ? 235.524 272.721 367.877 1.00 17.51 ? 235 ASN A CG  1 
ATOM   1380 O OD1 . ASN A 1 235 ? 236.462 272.148 368.426 1.00 26.68 ? 235 ASN A OD1 1 
ATOM   1381 N ND2 . ASN A 1 235 ? 234.481 273.189 368.549 1.00 24.72 ? 235 ASN A ND2 1 
ATOM   1382 N N   . ASP A 1 236 ? 239.145 273.213 366.519 1.00 17.32 ? 236 ASP A N   1 
ATOM   1383 C CA  . ASP A 1 236 ? 240.214 274.060 367.043 1.00 15.30 ? 236 ASP A CA  1 
ATOM   1384 C C   . ASP A 1 236 ? 240.789 274.857 365.880 1.00 13.50 ? 236 ASP A C   1 
ATOM   1385 O O   . ASP A 1 236 ? 241.634 274.365 365.131 1.00 22.83 ? 236 ASP A O   1 
ATOM   1386 C CB  . ASP A 1 236 ? 241.289 273.221 367.725 1.00 15.30 ? 236 ASP A CB  1 
ATOM   1387 C CG  . ASP A 1 236 ? 242.359 274.071 368.385 1.00 22.17 ? 236 ASP A CG  1 
ATOM   1388 O OD1 . ASP A 1 236 ? 242.188 275.306 368.438 1.00 25.48 ? 236 ASP A OD1 1 
ATOM   1389 O OD2 . ASP A 1 236 ? 243.372 273.508 368.847 1.00 24.90 ? 236 ASP A OD2 1 
ATOM   1390 N N   . PHE A 1 237 ? 240.329 276.096 365.726 1.00 16.20 ? 237 PHE A N   1 
ATOM   1391 C CA  . PHE A 1 237 ? 240.696 276.929 364.590 1.00 14.94 ? 237 PHE A CA  1 
ATOM   1392 C C   . PHE A 1 237 ? 241.639 278.064 364.965 1.00 9.07  ? 237 PHE A C   1 
ATOM   1393 O O   . PHE A 1 237 ? 241.916 278.925 364.125 1.00 20.30 ? 237 PHE A O   1 
ATOM   1394 C CB  . PHE A 1 237 ? 239.437 277.494 363.935 1.00 10.94 ? 237 PHE A CB  1 
ATOM   1395 C CG  . PHE A 1 237 ? 238.471 276.444 363.476 1.00 16.82 ? 237 PHE A CG  1 
ATOM   1396 C CD1 . PHE A 1 237 ? 238.809 275.570 362.458 1.00 18.06 ? 237 PHE A CD1 1 
ATOM   1397 C CD2 . PHE A 1 237 ? 237.222 276.334 364.060 1.00 14.55 ? 237 PHE A CD2 1 
ATOM   1398 C CE1 . PHE A 1 237 ? 237.920 274.604 362.033 1.00 18.25 ? 237 PHE A CE1 1 
ATOM   1399 C CE2 . PHE A 1 237 ? 236.327 275.372 363.634 1.00 16.44 ? 237 PHE A CE2 1 
ATOM   1400 C CZ  . PHE A 1 237 ? 236.678 274.505 362.622 1.00 16.33 ? 237 PHE A CZ  1 
ATOM   1401 N N   . GLY A 1 238 ? 242.142 278.088 366.191 1.00 8.68  ? 238 GLY A N   1 
ATOM   1402 C CA  . GLY A 1 238 ? 243.004 279.167 366.628 1.00 11.69 ? 238 GLY A CA  1 
ATOM   1403 C C   . GLY A 1 238 ? 242.219 280.336 367.194 1.00 9.55  ? 238 GLY A C   1 
ATOM   1404 O O   . GLY A 1 238 ? 241.067 280.212 367.618 1.00 15.20 ? 238 GLY A O   1 
ATOM   1405 N N   . SER A 1 239 ? 242.867 281.498 367.196 1.00 12.94 ? 239 SER A N   1 
ATOM   1406 C CA  . SER A 1 239 ? 242.295 282.690 367.802 1.00 9.85  ? 239 SER A CA  1 
ATOM   1407 C C   . SER A 1 239 ? 242.619 283.911 366.955 1.00 9.68  ? 239 SER A C   1 
ATOM   1408 O O   . SER A 1 239 ? 243.427 283.860 366.027 1.00 13.72 ? 239 SER A O   1 
ATOM   1409 C CB  . SER A 1 239 ? 242.810 282.892 369.233 1.00 4.78  ? 239 SER A CB  1 
ATOM   1410 O OG  . SER A 1 239 ? 242.360 281.859 370.089 1.00 14.36 ? 239 SER A OG  1 
ATOM   1411 N N   . LEU A 1 240 ? 241.957 285.013 367.282 1.00 8.68  ? 240 LEU A N   1 
ATOM   1412 C CA  . LEU A 1 240 ? 242.287 286.332 366.765 1.00 7.95  ? 240 LEU A CA  1 
ATOM   1413 C C   . LEU A 1 240 ? 242.779 287.192 367.918 1.00 5.68  ? 240 LEU A C   1 
ATOM   1414 O O   . LEU A 1 240 ? 242.106 287.300 368.947 1.00 15.78 ? 240 LEU A O   1 
ATOM   1415 C CB  . LEU A 1 240 ? 241.077 286.992 366.100 1.00 9.12  ? 240 LEU A CB  1 
ATOM   1416 C CG  . LEU A 1 240 ? 240.519 286.326 364.842 1.00 9.88  ? 240 LEU A CG  1 
ATOM   1417 C CD1 . LEU A 1 240 ? 239.342 287.120 364.304 1.00 12.31 ? 240 LEU A CD1 1 
ATOM   1418 C CD2 . LEU A 1 240 ? 241.599 286.179 363.784 1.00 15.85 ? 240 LEU A CD2 1 
ATOM   1419 N N   . ALA A 1 241 ? 243.952 287.789 367.749 1.00 8.72  ? 241 ALA A N   1 
ATOM   1420 C CA  . ALA A 1 241 ? 244.514 288.717 368.718 1.00 8.51  ? 241 ALA A CA  1 
ATOM   1421 C C   . ALA A 1 241 ? 244.409 290.120 368.140 1.00 5.26  ? 241 ALA A C   1 
ATOM   1422 O O   . ALA A 1 241 ? 244.909 290.384 367.043 1.00 17.12 ? 241 ALA A O   1 
ATOM   1423 C CB  . ALA A 1 241 ? 245.963 288.363 369.045 1.00 4.43  ? 241 ALA A CB  1 
ATOM   1424 N N   . VAL A 1 242 ? 243.758 291.012 368.872 1.00 4.72  ? 242 VAL A N   1 
ATOM   1425 C CA  . VAL A 1 242 ? 243.441 292.349 368.395 1.00 11.21 ? 242 VAL A CA  1 
ATOM   1426 C C   . VAL A 1 242 ? 244.120 293.354 369.309 1.00 8.95  ? 242 VAL A C   1 
ATOM   1427 O O   . VAL A 1 242 ? 244.020 293.247 370.537 1.00 14.21 ? 242 VAL A O   1 
ATOM   1428 C CB  . VAL A 1 242 ? 241.921 292.587 368.350 1.00 8.81  ? 242 VAL A CB  1 
ATOM   1429 C CG1 . VAL A 1 242 ? 241.619 293.999 367.882 1.00 11.13 ? 242 VAL A CG1 1 
ATOM   1430 C CG2 . VAL A 1 242 ? 241.253 291.559 367.450 1.00 13.34 ? 242 VAL A CG2 1 
ATOM   1431 N N   . ARG A 1 243 ? 244.818 294.316 368.711 1.00 7.69  ? 243 ARG A N   1 
ATOM   1432 C CA  . ARG A 1 243 ? 245.411 295.416 369.457 1.00 5.88  ? 243 ARG A CA  1 
ATOM   1433 C C   . ARG A 1 243 ? 245.259 296.703 368.661 1.00 8.40  ? 243 ARG A C   1 
ATOM   1434 O O   . ARG A 1 243 ? 244.990 296.686 367.459 1.00 16.34 ? 243 ARG A O   1 
ATOM   1435 C CB  . ARG A 1 243 ? 246.898 295.171 369.768 1.00 8.71  ? 243 ARG A CB  1 
ATOM   1436 C CG  . ARG A 1 243 ? 247.809 295.156 368.544 1.00 9.14  ? 243 ARG A CG  1 
ATOM   1437 C CD  . ARG A 1 243 ? 249.270 295.290 368.930 1.00 9.50  ? 243 ARG A CD  1 
ATOM   1438 N NE  . ARG A 1 243 ? 250.145 295.308 367.764 1.00 8.31  ? 243 ARG A NE  1 
ATOM   1439 C CZ  . ARG A 1 243 ? 251.446 295.564 367.806 1.00 4.64  ? 243 ARG A CZ  1 
ATOM   1440 N NH1 . ARG A 1 243 ? 252.060 295.843 368.943 1.00 11.04 ? 243 ARG A NH1 1 
ATOM   1441 N NH2 . ARG A 1 243 ? 252.147 295.544 366.677 1.00 9.42  ? 243 ARG A NH2 1 
ATOM   1442 N N   . VAL A 1 244 ? 245.435 297.825 369.350 1.00 12.66 ? 244 VAL A N   1 
ATOM   1443 C CA  . VAL A 1 244 ? 245.590 299.125 368.709 1.00 9.33  ? 244 VAL A CA  1 
ATOM   1444 C C   . VAL A 1 244 ? 247.082 299.386 368.574 1.00 6.71  ? 244 VAL A C   1 
ATOM   1445 O O   . VAL A 1 244 ? 247.805 299.438 369.576 1.00 14.92 ? 244 VAL A O   1 
ATOM   1446 C CB  . VAL A 1 244 ? 244.895 300.240 369.507 1.00 10.45 ? 244 VAL A CB  1 
ATOM   1447 C CG1 . VAL A 1 244 ? 245.286 301.607 368.962 1.00 13.84 ? 244 VAL A CG1 1 
ATOM   1448 C CG2 . VAL A 1 244 ? 243.389 300.060 369.461 1.00 13.82 ? 244 VAL A CG2 1 
ATOM   1449 N N   . VAL A 1 245 ? 247.545 299.539 367.333 1.00 8.51  ? 245 VAL A N   1 
ATOM   1450 C CA  . VAL A 1 245 ? 248.974 299.684 367.085 1.00 9.42  ? 245 VAL A CA  1 
ATOM   1451 C C   . VAL A 1 245 ? 249.486 301.017 367.613 1.00 9.82  ? 245 VAL A C   1 
ATOM   1452 O O   . VAL A 1 245 ? 250.646 301.123 368.024 1.00 18.16 ? 245 VAL A O   1 
ATOM   1453 C CB  . VAL A 1 245 ? 249.263 299.515 365.582 1.00 11.46 ? 245 VAL A CB  1 
ATOM   1454 C CG1 . VAL A 1 245 ? 250.747 299.684 365.298 1.00 12.84 ? 245 VAL A CG1 1 
ATOM   1455 C CG2 . VAL A 1 245 ? 248.776 298.154 365.105 1.00 10.38 ? 245 VAL A CG2 1 
ATOM   1456 N N   . ASN A 1 246 ? 248.642 302.046 367.613 1.00 9.12  ? 246 ASN A N   1 
ATOM   1457 C CA  . ASN A 1 246 ? 249.064 303.365 368.061 1.00 11.68 ? 246 ASN A CA  1 
ATOM   1458 C C   . ASN A 1 246 ? 249.533 303.323 369.507 1.00 12.30 ? 246 ASN A C   1 
ATOM   1459 O O   . ASN A 1 246 ? 248.978 302.602 370.339 1.00 20.64 ? 246 ASN A O   1 
ATOM   1460 C CB  . ASN A 1 246 ? 247.912 304.366 367.934 1.00 7.68  ? 246 ASN A CB  1 
ATOM   1461 C CG  . ASN A 1 246 ? 247.360 304.450 366.530 1.00 8.92  ? 246 ASN A CG  1 
ATOM   1462 O OD1 . ASN A 1 246 ? 246.757 303.503 366.030 1.00 14.58 ? 246 ASN A OD1 1 
ATOM   1463 N ND2 . ASN A 1 246 ? 247.555 305.592 365.890 1.00 12.03 ? 246 ASN A ND2 1 
ATOM   1464 N N   . ASP A 1 247 ? 250.567 304.103 369.804 1.00 14.09 ? 247 ASP A N   1 
ATOM   1465 C CA  . ASP A 1 247 ? 250.873 304.419 371.189 1.00 18.37 ? 247 ASP A CA  1 
ATOM   1466 C C   . ASP A 1 247 ? 249.760 305.285 371.767 1.00 18.67 ? 247 ASP A C   1 
ATOM   1467 O O   . ASP A 1 247 ? 249.064 306.004 371.046 1.00 22.73 ? 247 ASP A O   1 
ATOM   1468 C CB  . ASP A 1 247 ? 252.219 305.132 371.293 1.00 10.39 ? 247 ASP A CB  1 
ATOM   1469 C CG  . ASP A 1 247 ? 253.377 304.239 370.909 1.00 17.55 ? 247 ASP A CG  1 
ATOM   1470 O OD1 . ASP A 1 247 ? 253.425 303.085 371.381 1.00 23.04 ? 247 ASP A OD1 1 
ATOM   1471 O OD2 . ASP A 1 247 ? 254.235 304.687 370.124 1.00 23.17 ? 247 ASP A OD2 1 
ATOM   1472 N N   . HIS A 1 248 ? 249.586 305.198 373.080 1.00 19.06 ? 248 HIS A N   1 
ATOM   1473 C CA  . HIS A 1 248 ? 248.416 305.788 373.711 1.00 20.40 ? 248 HIS A CA  1 
ATOM   1474 C C   . HIS A 1 248 ? 248.432 307.308 373.601 1.00 20.66 ? 248 HIS A C   1 
ATOM   1475 O O   . HIS A 1 248 ? 249.487 307.947 373.602 1.00 27.88 ? 248 HIS A O   1 
ATOM   1476 C CB  . HIS A 1 248 ? 248.337 305.378 375.180 1.00 22.58 ? 248 HIS A CB  1 
ATOM   1477 C CG  . HIS A 1 248 ? 249.392 305.998 376.041 1.00 23.91 ? 248 HIS A CG  1 
ATOM   1478 N ND1 . HIS A 1 248 ? 250.641 305.440 376.206 1.00 24.20 ? 248 HIS A ND1 1 
ATOM   1479 C CD2 . HIS A 1 248 ? 249.382 307.125 376.791 1.00 24.02 ? 248 HIS A CD2 1 
ATOM   1480 C CE1 . HIS A 1 248 ? 251.355 306.198 377.018 1.00 23.63 ? 248 HIS A CE1 1 
ATOM   1481 N NE2 . HIS A 1 248 ? 250.615 307.227 377.387 1.00 26.77 ? 248 HIS A NE2 1 
ATOM   1482 N N   . ASN A 1 249 ? 247.242 307.876 373.491 1.00 23.48 ? 249 ASN A N   1 
ATOM   1483 C CA  . ASN A 1 249 ? 247.032 309.309 373.621 1.00 21.01 ? 249 ASN A CA  1 
ATOM   1484 C C   . ASN A 1 249 ? 246.835 309.664 375.084 1.00 23.01 ? 249 ASN A C   1 
ATOM   1485 O O   . ASN A 1 249 ? 246.704 308.789 375.943 1.00 25.12 ? 249 ASN A O   1 
ATOM   1486 C CB  . ASN A 1 249 ? 245.823 309.729 372.789 1.00 21.91 ? 249 ASN A CB  1 
ATOM   1487 C CG  . ASN A 1 249 ? 246.035 309.526 371.304 1.00 21.19 ? 249 ASN A CG  1 
ATOM   1488 O OD1 . ASN A 1 249 ? 246.510 310.420 370.605 1.00 21.20 ? 249 ASN A OD1 1 
ATOM   1489 N ND2 . ASN A 1 249 ? 245.680 308.347 370.813 1.00 21.81 ? 249 ASN A ND2 1 
ATOM   1490 N N   . PRO A 1 250 ? 246.817 310.956 375.417 1.00 26.34 ? 250 PRO A N   1 
ATOM   1491 C CA  . PRO A 1 250 ? 246.561 311.341 376.814 1.00 26.58 ? 250 PRO A CA  1 
ATOM   1492 C C   . PRO A 1 250 ? 245.200 310.900 377.325 1.00 25.51 ? 250 PRO A C   1 
ATOM   1493 O O   . PRO A 1 250 ? 245.018 310.804 378.544 1.00 28.91 ? 250 PRO A O   1 
ATOM   1494 C CB  . PRO A 1 250 ? 246.683 312.871 376.785 1.00 29.71 ? 250 PRO A CB  1 
ATOM   1495 C CG  . PRO A 1 250 ? 247.522 313.165 375.589 1.00 29.42 ? 250 PRO A CG  1 
ATOM   1496 C CD  . PRO A 1 250 ? 247.171 312.117 374.582 1.00 26.38 ? 250 PRO A CD  1 
ATOM   1497 N N   . THR A 1 251 ? 244.243 310.631 376.443 1.00 23.26 ? 251 THR A N   1 
ATOM   1498 C CA  . THR A 1 251 ? 242.910 310.201 376.831 1.00 25.90 ? 251 THR A CA  1 
ATOM   1499 C C   . THR A 1 251 ? 242.682 308.758 376.398 1.00 24.06 ? 251 THR A C   1 
ATOM   1500 O O   . THR A 1 251 ? 243.190 308.313 375.366 1.00 26.98 ? 251 THR A O   1 
ATOM   1501 C CB  . THR A 1 251 ? 241.834 311.105 376.216 1.00 26.30 ? 251 THR A CB  1 
ATOM   1502 O OG1 . THR A 1 251 ? 240.566 310.826 376.820 1.00 32.79 ? 251 THR A OG1 1 
ATOM   1503 C CG2 . THR A 1 251 ? 241.733 310.888 374.713 1.00 25.50 ? 251 THR A CG2 1 
ATOM   1504 N N   . LYS A 1 252 ? 241.912 308.032 377.203 1.00 23.15 ? 252 LYS A N   1 
ATOM   1505 C CA  . LYS A 1 252 ? 241.609 306.641 376.899 1.00 20.53 ? 252 LYS A CA  1 
ATOM   1506 C C   . LYS A 1 252 ? 240.588 306.545 375.773 1.00 20.01 ? 252 LYS A C   1 
ATOM   1507 O O   . LYS A 1 252 ? 239.610 307.296 375.729 1.00 25.82 ? 252 LYS A O   1 
ATOM   1508 C CB  . LYS A 1 252 ? 241.079 305.931 378.146 1.00 23.24 ? 252 LYS A CB  1 
ATOM   1509 C CG  . LYS A 1 252 ? 240.656 304.487 377.907 1.00 24.75 ? 252 LYS A CG  1 
ATOM   1510 C CD  . LYS A 1 252 ? 240.113 303.841 379.170 1.00 23.97 ? 252 LYS A CD  1 
ATOM   1511 C CE  . LYS A 1 252 ? 239.702 302.401 378.915 1.00 24.80 ? 252 LYS A CE  1 
ATOM   1512 N NZ  . LYS A 1 252 ? 239.149 301.745 380.131 1.00 29.60 ? 252 LYS A NZ  1 
ATOM   1513 N N   . LEU A 1 253 ? 240.820 305.610 374.860 1.00 17.37 ? 253 LEU A N   1 
ATOM   1514 C CA  . LEU A 1 253 ? 239.893 305.310 373.780 1.00 17.09 ? 253 LEU A CA  1 
ATOM   1515 C C   . LEU A 1 253 ? 239.499 303.846 373.872 1.00 18.93 ? 253 LEU A C   1 
ATOM   1516 O O   . LEU A 1 253 ? 240.335 302.991 374.177 1.00 24.72 ? 253 LEU A O   1 
ATOM   1517 C CB  . LEU A 1 253 ? 240.516 305.595 372.410 1.00 16.95 ? 253 LEU A CB  1 
ATOM   1518 C CG  . LEU A 1 253 ? 241.167 306.970 372.248 1.00 20.44 ? 253 LEU A CG  1 
ATOM   1519 C CD1 . LEU A 1 253 ? 241.859 307.070 370.902 1.00 20.41 ? 253 LEU A CD1 1 
ATOM   1520 C CD2 . LEU A 1 253 ? 240.137 308.073 372.409 1.00 18.46 ? 253 LEU A CD2 1 
ATOM   1521 N N   . THR A 1 254 ? 238.228 303.555 373.619 1.00 16.53 ? 254 THR A N   1 
ATOM   1522 C CA  . THR A 1 254 ? 237.734 302.187 373.642 1.00 12.54 ? 254 THR A CA  1 
ATOM   1523 C C   . THR A 1 254 ? 237.196 301.830 372.268 1.00 8.26  ? 254 THR A C   1 
ATOM   1524 O O   . THR A 1 254 ? 236.461 302.612 371.660 1.00 22.89 ? 254 THR A O   1 
ATOM   1525 C CB  . THR A 1 254 ? 236.640 302.004 374.701 1.00 18.37 ? 254 THR A CB  1 
ATOM   1526 O OG1 . THR A 1 254 ? 237.202 302.179 376.007 1.00 27.31 ? 254 THR A OG1 1 
ATOM   1527 C CG2 . THR A 1 254 ? 236.024 300.616 374.602 1.00 18.50 ? 254 THR A CG2 1 
ATOM   1528 N N   . SER A 1 255 ? 237.558 300.644 371.782 1.00 8.57  ? 255 SER A N   1 
ATOM   1529 C CA  . SER A 1 255 ? 237.144 300.181 370.470 1.00 12.21 ? 255 SER A CA  1 
ATOM   1530 C C   . SER A 1 255 ? 236.536 298.792 370.582 1.00 9.20  ? 255 SER A C   1 
ATOM   1531 O O   . SER A 1 255 ? 236.893 298.002 371.459 1.00 19.23 ? 255 SER A O   1 
ATOM   1532 C CB  . SER A 1 255 ? 238.319 300.149 369.482 1.00 8.81  ? 255 SER A CB  1 
ATOM   1533 O OG  . SER A 1 255 ? 238.917 301.424 369.350 1.00 15.48 ? 255 SER A OG  1 
ATOM   1534 N N   . LYS A 1 256 ? 235.603 298.511 369.679 1.00 12.76 ? 256 LYS A N   1 
ATOM   1535 C CA  . LYS A 1 256 ? 235.012 297.192 369.528 1.00 7.82  ? 256 LYS A CA  1 
ATOM   1536 C C   . LYS A 1 256 ? 235.151 296.756 368.080 1.00 12.22 ? 256 LYS A C   1 
ATOM   1537 O O   . LYS A 1 256 ? 234.836 297.518 367.157 1.00 15.81 ? 256 LYS A O   1 
ATOM   1538 C CB  . LYS A 1 256 ? 233.540 297.180 369.956 1.00 9.47  ? 256 LYS A CB  1 
ATOM   1539 C CG  . LYS A 1 256 ? 233.350 297.247 371.461 1.00 15.57 ? 256 LYS A CG  1 
ATOM   1540 C CD  . LYS A 1 256 ? 231.890 297.190 371.861 1.00 15.69 ? 256 LYS A CD  1 
ATOM   1541 C CE  . LYS A 1 256 ? 231.738 297.216 373.375 1.00 14.99 ? 256 LYS A CE  1 
ATOM   1542 N NZ  . LYS A 1 256 ? 230.321 297.392 373.789 1.00 21.10 ? 256 LYS A NZ  1 
ATOM   1543 N N   . ILE A 1 257 ? 235.648 295.541 367.892 1.00 9.96  ? 257 ILE A N   1 
ATOM   1544 C CA  . ILE A 1 257 ? 235.748 294.907 366.587 1.00 8.71  ? 257 ILE A CA  1 
ATOM   1545 C C   . ILE A 1 257 ? 234.664 293.841 366.537 1.00 10.00 ? 257 ILE A C   1 
ATOM   1546 O O   . ILE A 1 257 ? 234.704 292.861 367.287 1.00 15.86 ? 257 ILE A O   1 
ATOM   1547 C CB  . ILE A 1 257 ? 237.145 294.313 366.349 1.00 8.89  ? 257 ILE A CB  1 
ATOM   1548 C CG1 . ILE A 1 257 ? 238.209 295.417 366.328 1.00 14.32 ? 257 ILE A CG1 1 
ATOM   1549 C CG2 . ILE A 1 257 ? 237.183 293.534 365.044 1.00 8.94  ? 257 ILE A CG2 1 
ATOM   1550 C CD1 . ILE A 1 257 ? 238.623 295.915 367.694 1.00 10.02 ? 257 ILE A CD1 1 
ATOM   1551 N N   . ARG A 1 258 ? 233.675 294.046 365.681 1.00 12.05 ? 258 ARG A N   1 
ATOM   1552 C CA  . ARG A 1 258 ? 232.614 293.078 365.470 1.00 8.34  ? 258 ARG A CA  1 
ATOM   1553 C C   . ARG A 1 258 ? 233.007 292.190 364.301 1.00 5.63  ? 258 ARG A C   1 
ATOM   1554 O O   . ARG A 1 258 ? 233.280 292.683 363.199 1.00 16.80 ? 258 ARG A O   1 
ATOM   1555 C CB  . ARG A 1 258 ? 231.283 293.780 365.211 1.00 4.30  ? 258 ARG A CB  1 
ATOM   1556 C CG  . ARG A 1 258 ? 230.676 294.381 366.462 1.00 8.41  ? 258 ARG A CG  1 
ATOM   1557 C CD  . ARG A 1 258 ? 229.477 295.255 366.160 1.00 8.33  ? 258 ARG A CD  1 
ATOM   1558 N NE  . ARG A 1 258 ? 228.702 295.536 367.362 1.00 9.55  ? 258 ARG A NE  1 
ATOM   1559 C CZ  . ARG A 1 258 ? 229.042 296.425 368.285 1.00 8.63  ? 258 ARG A CZ  1 
ATOM   1560 N NH1 . ARG A 1 258 ? 230.150 297.140 368.184 1.00 13.64 ? 258 ARG A NH1 1 
ATOM   1561 N NH2 . ARG A 1 258 ? 228.250 296.602 369.338 1.00 11.98 ? 258 ARG A NH2 1 
ATOM   1562 N N   . VAL A 1 259 ? 233.053 290.890 364.554 1.00 9.62  ? 259 VAL A N   1 
ATOM   1563 C CA  . VAL A 1 259 ? 233.446 289.899 363.566 1.00 8.89  ? 259 VAL A CA  1 
ATOM   1564 C C   . VAL A 1 259 ? 232.181 289.320 362.954 1.00 3.19  ? 259 VAL A C   1 
ATOM   1565 O O   . VAL A 1 259 ? 231.316 288.804 363.670 1.00 12.30 ? 259 VAL A O   1 
ATOM   1566 C CB  . VAL A 1 259 ? 234.311 288.797 364.203 1.00 5.57  ? 259 VAL A CB  1 
ATOM   1567 C CG1 . VAL A 1 259 ? 234.802 287.822 363.148 1.00 4.38  ? 259 VAL A CG1 1 
ATOM   1568 C CG2 . VAL A 1 259 ? 235.477 289.411 364.968 1.00 8.31  ? 259 VAL A CG2 1 
ATOM   1569 N N   . TYR A 1 260 ? 232.071 289.408 361.636 1.00 1.98  ? 260 TYR A N   1 
ATOM   1570 C CA  . TYR A 1 260 ? 230.947 288.866 360.896 1.00 5.75  ? 260 TYR A CA  1 
ATOM   1571 C C   . TYR A 1 260 ? 231.442 287.737 360.009 1.00 4.69  ? 260 TYR A C   1 
ATOM   1572 O O   . TYR A 1 260 ? 232.431 287.889 359.286 1.00 16.82 ? 260 TYR A O   1 
ATOM   1573 C CB  . TYR A 1 260 ? 230.263 289.953 360.060 1.00 6.30  ? 260 TYR A CB  1 
ATOM   1574 C CG  . TYR A 1 260 ? 229.661 291.039 360.914 1.00 10.14 ? 260 TYR A CG  1 
ATOM   1575 C CD1 . TYR A 1 260 ? 230.447 292.066 361.418 1.00 1.57  ? 260 TYR A CD1 1 
ATOM   1576 C CD2 . TYR A 1 260 ? 228.313 291.026 361.240 1.00 6.41  ? 260 TYR A CD2 1 
ATOM   1577 C CE1 . TYR A 1 260 ? 229.907 293.049 362.208 1.00 6.20  ? 260 TYR A CE1 1 
ATOM   1578 C CE2 . TYR A 1 260 ? 227.764 292.010 362.031 1.00 0.13  ? 260 TYR A CE2 1 
ATOM   1579 C CZ  . TYR A 1 260 ? 228.567 293.017 362.516 1.00 5.71  ? 260 TYR A CZ  1 
ATOM   1580 O OH  . TYR A 1 260 ? 228.033 294.002 363.308 1.00 17.28 ? 260 TYR A OH  1 
ATOM   1581 N N   . MET A 1 261 ? 230.751 286.608 360.078 1.00 6.40  ? 261 MET A N   1 
ATOM   1582 C CA  . MET A 1 261 ? 231.142 285.390 359.391 1.00 9.61  ? 261 MET A CA  1 
ATOM   1583 C C   . MET A 1 261 ? 230.120 285.087 358.309 1.00 4.58  ? 261 MET A C   1 
ATOM   1584 O O   . MET A 1 261 ? 228.912 285.146 358.560 1.00 12.35 ? 261 MET A O   1 
ATOM   1585 C CB  . MET A 1 261 ? 231.241 284.231 360.387 1.00 8.86  ? 261 MET A CB  1 
ATOM   1586 C CG  . MET A 1 261 ? 231.589 282.888 359.783 1.00 17.64 ? 261 MET A CG  1 
ATOM   1587 S SD  . MET A 1 261 ? 231.570 281.562 361.009 1.00 34.78 ? 261 MET A SD  1 
ATOM   1588 C CE  . MET A 1 261 ? 232.722 282.193 362.226 1.00 10.87 ? 261 MET A CE  1 
ATOM   1589 N N   . LYS A 1 262 ? 230.600 284.780 357.112 1.00 5.46  ? 262 LYS A N   1 
ATOM   1590 C CA  . LYS A 1 262 ? 229.734 284.358 356.014 1.00 6.61  ? 262 LYS A CA  1 
ATOM   1591 C C   . LYS A 1 262 ? 230.275 283.064 355.426 1.00 5.89  ? 262 LYS A C   1 
ATOM   1592 O O   . LYS A 1 262 ? 231.372 283.070 354.828 1.00 15.22 ? 262 LYS A O   1 
ATOM   1593 C CB  . LYS A 1 262 ? 229.625 285.434 354.937 1.00 10.21 ? 262 LYS A CB  1 
ATOM   1594 C CG  . LYS A 1 262 ? 228.572 285.118 353.887 1.00 9.87  ? 262 LYS A CG  1 
ATOM   1595 C CD  . LYS A 1 262 ? 228.424 286.229 352.864 1.00 11.06 ? 262 LYS A CD  1 
ATOM   1596 C CE  . LYS A 1 262 ? 229.630 286.307 351.942 1.00 11.80 ? 262 LYS A CE  1 
ATOM   1597 N NZ  . LYS A 1 262 ? 229.417 287.275 350.836 1.00 21.57 ? 262 LYS A NZ  1 
ATOM   1598 N N   . PRO A 1 263 ? 229.582 281.941 355.593 1.00 7.81  ? 263 PRO A N   1 
ATOM   1599 C CA  . PRO A 1 263 ? 229.961 280.736 354.849 1.00 9.60  ? 263 PRO A CA  1 
ATOM   1600 C C   . PRO A 1 263 ? 229.724 280.922 353.359 1.00 8.25  ? 263 PRO A C   1 
ATOM   1601 O O   . PRO A 1 263 ? 228.732 281.521 352.939 1.00 15.91 ? 263 PRO A O   1 
ATOM   1602 C CB  . PRO A 1 263 ? 229.049 279.650 355.436 1.00 7.23  ? 263 PRO A CB  1 
ATOM   1603 C CG  . PRO A 1 263 ? 228.586 280.193 356.745 1.00 13.20 ? 263 PRO A CG  1 
ATOM   1604 C CD  . PRO A 1 263 ? 228.509 281.672 356.563 1.00 6.88  ? 263 PRO A CD  1 
ATOM   1605 N N   . LYS A 1 264 ? 230.648 280.401 352.563 1.00 3.93  ? 264 LYS A N   1 
ATOM   1606 C CA  . LYS A 1 264 ? 230.573 280.460 351.114 1.00 6.45  ? 264 LYS A CA  1 
ATOM   1607 C C   . LYS A 1 264 ? 230.881 279.085 350.542 1.00 4.51  ? 264 LYS A C   1 
ATOM   1608 O O   . LYS A 1 264 ? 231.642 278.309 351.126 1.00 13.54 ? 264 LYS A O   1 
ATOM   1609 C CB  . LYS A 1 264 ? 231.552 281.488 350.541 1.00 11.13 ? 264 LYS A CB  1 
ATOM   1610 C CG  . LYS A 1 264 ? 231.349 282.895 351.073 1.00 15.61 ? 264 LYS A CG  1 
ATOM   1611 C CD  . LYS A 1 264 ? 232.400 283.860 350.543 1.00 15.05 ? 264 LYS A CD  1 
ATOM   1612 C CE  . LYS A 1 264 ? 232.453 283.864 349.023 1.00 13.13 ? 264 LYS A CE  1 
ATOM   1613 N NZ  . LYS A 1 264 ? 231.101 283.975 348.407 1.00 23.10 ? 264 LYS A NZ  1 
ATOM   1614 N N   . HIS A 1 265 ? 230.297 278.801 349.381 1.00 11.05 ? 265 HIS A N   1 
ATOM   1615 C CA  . HIS A 1 265 ? 230.450 277.502 348.733 1.00 14.03 ? 265 HIS A CA  1 
ATOM   1616 C C   . HIS A 1 265 ? 230.085 276.390 349.712 1.00 8.06  ? 265 HIS A C   1 
ATOM   1617 O O   . HIS A 1 265 ? 230.859 275.469 349.976 1.00 10.56 ? 265 HIS A O   1 
ATOM   1618 C CB  . HIS A 1 265 ? 231.870 277.331 348.194 1.00 7.86  ? 265 HIS A CB  1 
ATOM   1619 C CG  . HIS A 1 265 ? 232.371 278.525 347.444 1.00 17.04 ? 265 HIS A CG  1 
ATOM   1620 N ND1 . HIS A 1 265 ? 233.335 279.370 347.949 1.00 17.44 ? 265 HIS A ND1 1 
ATOM   1621 C CD2 . HIS A 1 265 ? 232.023 279.030 346.237 1.00 12.44 ? 265 HIS A CD2 1 
ATOM   1622 C CE1 . HIS A 1 265 ? 233.570 280.335 347.078 1.00 20.37 ? 265 HIS A CE1 1 
ATOM   1623 N NE2 . HIS A 1 265 ? 232.786 280.153 346.032 1.00 17.03 ? 265 HIS A NE2 1 
ATOM   1624 N N   . VAL A 1 266 ? 228.886 276.498 350.260 1.00 7.71  ? 266 VAL A N   1 
ATOM   1625 C CA  . VAL A 1 266 ? 228.471 275.680 351.389 1.00 9.70  ? 266 VAL A CA  1 
ATOM   1626 C C   . VAL A 1 266 ? 227.975 274.329 350.898 1.00 4.84  ? 266 VAL A C   1 
ATOM   1627 O O   . VAL A 1 266 ? 227.239 274.233 349.910 1.00 12.55 ? 266 VAL A O   1 
ATOM   1628 C CB  . VAL A 1 266 ? 227.387 276.410 352.203 1.00 13.35 ? 266 VAL A CB  1 
ATOM   1629 C CG1 . VAL A 1 266 ? 226.894 275.535 353.345 1.00 6.55  ? 266 VAL A CG1 1 
ATOM   1630 C CG2 . VAL A 1 266 ? 227.919 277.739 352.728 1.00 7.20  ? 266 VAL A CG2 1 
ATOM   1631 N N   . ARG A 1 267 ? 228.402 273.275 351.583 1.00 10.27 ? 267 ARG A N   1 
ATOM   1632 C CA  . ARG A 1 267 ? 227.814 271.951 351.464 1.00 7.54  ? 267 ARG A CA  1 
ATOM   1633 C C   . ARG A 1 267 ? 227.488 271.467 352.867 1.00 3.29  ? 267 ARG A C   1 
ATOM   1634 O O   . ARG A 1 267 ? 228.261 271.699 353.797 1.00 8.34  ? 267 ARG A O   1 
ATOM   1635 C CB  . ARG A 1 267 ? 228.760 270.970 350.763 1.00 5.89  ? 267 ARG A CB  1 
ATOM   1636 C CG  . ARG A 1 267 ? 229.080 271.342 349.325 1.00 2.86  ? 267 ARG A CG  1 
ATOM   1637 C CD  . ARG A 1 267 ? 230.050 270.362 348.694 1.00 2.72  ? 267 ARG A CD  1 
ATOM   1638 N NE  . ARG A 1 267 ? 229.495 269.017 348.600 1.00 10.56 ? 267 ARG A NE  1 
ATOM   1639 C CZ  . ARG A 1 267 ? 230.163 267.957 348.167 1.00 6.48  ? 267 ARG A CZ  1 
ATOM   1640 N NH1 . ARG A 1 267 ? 231.427 268.044 347.784 1.00 10.71 ? 267 ARG A NH1 1 
ATOM   1641 N NH2 . ARG A 1 267 ? 229.549 266.780 348.119 1.00 10.84 ? 267 ARG A NH2 1 
ATOM   1642 N N   . VAL A 1 268 ? 226.334 270.824 353.031 1.00 4.63  ? 268 VAL A N   1 
ATOM   1643 C CA  . VAL A 1 268 ? 225.893 270.362 354.341 1.00 2.86  ? 268 VAL A CA  1 
ATOM   1644 C C   . VAL A 1 268 ? 225.355 268.944 354.226 1.00 0.39  ? 268 VAL A C   1 
ATOM   1645 O O   . VAL A 1 268 ? 224.913 268.502 353.165 1.00 5.58  ? 268 VAL A O   1 
ATOM   1646 C CB  . VAL A 1 268 ? 224.829 271.295 354.966 1.00 4.51  ? 268 VAL A CB  1 
ATOM   1647 C CG1 . VAL A 1 268 ? 225.472 272.590 355.421 1.00 4.17  ? 268 VAL A CG1 1 
ATOM   1648 C CG2 . VAL A 1 268 ? 223.702 271.564 353.980 1.00 4.93  ? 268 VAL A CG2 1 
ATOM   1649 N N   . TRP A 1 269 ? 225.399 268.234 355.351 1.00 7.09  ? 269 TRP A N   1 
ATOM   1650 C CA  . TRP A 1 269 ? 224.991 266.841 355.423 1.00 1.60  ? 269 TRP A CA  1 
ATOM   1651 C C   . TRP A 1 269 ? 224.248 266.573 356.723 1.00 0.01  ? 269 TRP A C   1 
ATOM   1652 O O   . TRP A 1 269 ? 224.573 267.140 357.776 1.00 8.11  ? 269 TRP A O   1 
ATOM   1653 C CB  . TRP A 1 269 ? 226.184 265.880 355.357 1.00 2.55  ? 269 TRP A CB  1 
ATOM   1654 C CG  . TRP A 1 269 ? 226.966 265.907 354.092 1.00 3.14  ? 269 TRP A CG  1 
ATOM   1655 C CD1 . TRP A 1 269 ? 226.810 265.086 353.018 1.00 4.44  ? 269 TRP A CD1 1 
ATOM   1656 C CD2 . TRP A 1 269 ? 228.054 266.783 353.773 1.00 0.01  ? 269 TRP A CD2 1 
ATOM   1657 N NE1 . TRP A 1 269 ? 227.726 265.397 352.047 1.00 4.57  ? 269 TRP A NE1 1 
ATOM   1658 C CE2 . TRP A 1 269 ? 228.504 266.435 352.486 1.00 6.15  ? 269 TRP A CE2 1 
ATOM   1659 C CE3 . TRP A 1 269 ? 228.687 267.830 354.449 1.00 0.33  ? 269 TRP A CE3 1 
ATOM   1660 C CZ2 . TRP A 1 269 ? 229.557 267.099 351.859 1.00 7.83  ? 269 TRP A CZ2 1 
ATOM   1661 C CZ3 . TRP A 1 269 ? 229.733 268.486 353.827 1.00 1.45  ? 269 TRP A CZ3 1 
ATOM   1662 C CH2 . TRP A 1 269 ? 230.157 268.118 352.546 1.00 2.17  ? 269 TRP A CH2 1 
ATOM   1663 N N   . CYS A 1 270 ? 223.287 265.637 356.632 1.00 4.92  ? 270 CYS A N   1 
ATOM   1664 C CA  . CYS A 1 270 ? 222.564 265.046 357.753 1.00 3.77  ? 270 CYS A CA  1 
ATOM   1665 C C   . CYS A 1 270 ? 221.772 266.091 358.529 1.00 0.47  ? 270 CYS A C   1 
ATOM   1666 O O   . CYS A 1 270 ? 222.171 266.490 359.628 1.00 3.51  ? 270 CYS A O   1 
ATOM   1667 C CB  . CYS A 1 270 ? 223.540 264.304 358.663 1.00 5.10  ? 270 CYS A CB  1 
ATOM   1668 S SG  . CYS A 1 270 ? 224.501 263.052 357.793 1.00 12.98 ? 270 CYS A SG  1 
ATOM   1669 N N   . PRO A 1 271 ? 220.656 266.565 357.976 1.00 5.67  ? 271 PRO A N   1 
ATOM   1670 C CA  . PRO A 1 271 ? 219.886 267.617 358.646 1.00 9.01  ? 271 PRO A CA  1 
ATOM   1671 C C   . PRO A 1 271 ? 219.354 267.160 359.995 1.00 0.01  ? 271 PRO A C   1 
ATOM   1672 O O   . PRO A 1 271 ? 219.120 265.975 360.233 1.00 4.88  ? 271 PRO A O   1 
ATOM   1673 C CB  . PRO A 1 271 ? 218.746 267.902 357.663 1.00 2.94  ? 271 PRO A CB  1 
ATOM   1674 C CG  . PRO A 1 271 ? 218.582 266.637 356.906 1.00 3.14  ? 271 PRO A CG  1 
ATOM   1675 C CD  . PRO A 1 271 ? 219.952 266.037 356.795 1.00 1.65  ? 271 PRO A CD  1 
ATOM   1676 N N   . ARG A 1 272 ? 219.173 268.125 360.879 1.00 0.01  ? 272 ARG A N   1 
ATOM   1677 C CA  . ARG A 1 272 ? 218.759 267.911 362.253 1.00 1.48  ? 272 ARG A CA  1 
ATOM   1678 C C   . ARG A 1 272 ? 217.608 268.850 362.569 1.00 7.37  ? 272 ARG A C   1 
ATOM   1679 O O   . ARG A 1 272 ? 217.460 269.897 361.931 1.00 13.79 ? 272 ARG A O   1 
ATOM   1680 C CB  . ARG A 1 272 ? 219.920 268.172 363.224 1.00 1.69  ? 272 ARG A CB  1 
ATOM   1681 C CG  . ARG A 1 272 ? 221.263 267.629 362.761 1.00 5.51  ? 272 ARG A CG  1 
ATOM   1682 C CD  . ARG A 1 272 ? 222.386 268.091 363.670 1.00 0.01  ? 272 ARG A CD  1 
ATOM   1683 N NE  . ARG A 1 272 ? 222.266 267.541 365.015 1.00 4.22  ? 272 ARG A NE  1 
ATOM   1684 C CZ  . ARG A 1 272 ? 222.694 266.338 365.375 1.00 4.94  ? 272 ARG A CZ  1 
ATOM   1685 N NH1 . ARG A 1 272 ? 223.270 265.523 364.509 1.00 1.87  ? 272 ARG A NH1 1 
ATOM   1686 N NH2 . ARG A 1 272 ? 222.536 265.943 366.633 1.00 5.14  ? 272 ARG A NH2 1 
ATOM   1687 N N   . PRO A 1 273 ? 216.770 268.504 363.539 1.00 9.98  ? 273 PRO A N   1 
ATOM   1688 C CA  . PRO A 1 273 ? 215.788 269.463 364.029 1.00 7.81  ? 273 PRO A CA  1 
ATOM   1689 C C   . PRO A 1 273 ? 216.487 270.680 364.607 1.00 5.14  ? 273 PRO A C   1 
ATOM   1690 O O   . PRO A 1 273 ? 217.527 270.549 365.268 1.00 8.84  ? 273 PRO A O   1 
ATOM   1691 C CB  . PRO A 1 273 ? 215.031 268.676 365.108 1.00 9.85  ? 273 PRO A CB  1 
ATOM   1692 C CG  . PRO A 1 273 ? 215.968 267.620 365.529 1.00 6.81  ? 273 PRO A CG  1 
ATOM   1693 C CD  . PRO A 1 273 ? 216.743 267.253 364.314 1.00 3.16  ? 273 PRO A CD  1 
ATOM   1694 N N   . PRO A 1 274 ? 215.964 271.880 364.378 1.00 12.20 ? 274 PRO A N   1 
ATOM   1695 C CA  . PRO A 1 274 ? 216.630 273.077 364.898 1.00 5.82  ? 274 PRO A CA  1 
ATOM   1696 C C   . PRO A 1 274 ? 216.539 273.166 366.412 1.00 3.44  ? 274 PRO A C   1 
ATOM   1697 O O   . PRO A 1 274 ? 215.665 272.580 367.052 1.00 16.33 ? 274 PRO A O   1 
ATOM   1698 C CB  . PRO A 1 274 ? 215.872 274.228 364.232 1.00 12.60 ? 274 PRO A CB  1 
ATOM   1699 C CG  . PRO A 1 274 ? 214.539 273.664 363.915 1.00 6.98  ? 274 PRO A CG  1 
ATOM   1700 C CD  . PRO A 1 274 ? 214.765 272.220 363.593 1.00 6.17  ? 274 PRO A CD  1 
ATOM   1701 N N   . ARG A 1 275 ? 217.474 273.924 366.979 1.00 7.75  ? 275 ARG A N   1 
ATOM   1702 C CA  . ARG A 1 275 ? 217.442 274.213 368.404 1.00 11.07 ? 275 ARG A CA  1 
ATOM   1703 C C   . ARG A 1 275 ? 216.103 274.836 368.775 1.00 5.62  ? 275 ARG A C   1 
ATOM   1704 O O   . ARG A 1 275 ? 215.662 275.803 368.150 1.00 9.74  ? 275 ARG A O   1 
ATOM   1705 C CB  . ARG A 1 275 ? 218.588 275.160 368.768 1.00 7.13  ? 275 ARG A CB  1 
ATOM   1706 C CG  . ARG A 1 275 ? 218.729 275.436 370.253 1.00 9.27  ? 275 ARG A CG  1 
ATOM   1707 C CD  . ARG A 1 275 ? 219.221 274.214 371.001 1.00 5.71  ? 275 ARG A CD  1 
ATOM   1708 N NE  . ARG A 1 275 ? 219.317 274.447 372.436 1.00 8.38  ? 275 ARG A NE  1 
ATOM   1709 C CZ  . ARG A 1 275 ? 219.950 273.649 373.283 1.00 6.60  ? 275 ARG A CZ  1 
ATOM   1710 N NH1 . ARG A 1 275 ? 220.585 272.564 372.869 1.00 10.56 ? 275 ARG A NH1 1 
ATOM   1711 N NH2 . ARG A 1 275 ? 219.950 273.947 374.578 1.00 6.84  ? 275 ARG A NH2 1 
ATOM   1712 N N   . ALA A 1 276 ? 215.461 274.284 369.803 1.00 10.96 ? 276 ALA A N   1 
ATOM   1713 C CA  . ALA A 1 276 ? 214.140 274.730 370.219 1.00 5.54  ? 276 ALA A CA  1 
ATOM   1714 C C   . ALA A 1 276 ? 214.127 275.433 371.566 1.00 5.77  ? 276 ALA A C   1 
ATOM   1715 O O   . ALA A 1 276 ? 213.188 276.184 371.840 1.00 17.17 ? 276 ALA A O   1 
ATOM   1716 C CB  . ALA A 1 276 ? 213.172 273.539 370.274 1.00 12.49 ? 276 ALA A CB  1 
ATOM   1717 N N   . VAL A 1 277 ? 215.131 275.210 372.401 1.00 13.41 ? 277 VAL A N   1 
ATOM   1718 C CA  . VAL A 1 277 ? 215.238 275.865 373.701 1.00 6.75  ? 277 VAL A CA  1 
ATOM   1719 C C   . VAL A 1 277 ? 216.526 276.672 373.696 1.00 8.22  ? 277 VAL A C   1 
ATOM   1720 O O   . VAL A 1 277 ? 217.431 276.418 372.883 1.00 13.92 ? 277 VAL A O   1 
ATOM   1721 C CB  . VAL A 1 277 ? 215.202 274.845 374.864 1.00 9.81  ? 277 VAL A CB  1 
ATOM   1722 C CG1 . VAL A 1 277 ? 213.899 274.065 374.847 1.00 10.09 ? 277 VAL A CG1 1 
ATOM   1723 C CG2 . VAL A 1 277 ? 216.402 273.900 374.794 1.00 7.42  ? 277 VAL A CG2 1 
ATOM   1724 N N   . PRO A 1 278 ? 216.651 277.653 374.589 1.00 13.49 ? 278 PRO A N   1 
ATOM   1725 C CA  . PRO A 1 278 ? 217.840 278.514 374.564 1.00 7.33  ? 278 PRO A CA  1 
ATOM   1726 C C   . PRO A 1 278 ? 219.120 277.701 374.688 1.00 8.76  ? 278 PRO A C   1 
ATOM   1727 O O   . PRO A 1 278 ? 219.193 276.732 375.445 1.00 15.67 ? 278 PRO A O   1 
ATOM   1728 C CB  . PRO A 1 278 ? 217.640 279.434 375.774 1.00 12.33 ? 278 PRO A CB  1 
ATOM   1729 C CG  . PRO A 1 278 ? 216.177 279.389 376.060 1.00 11.47 ? 278 PRO A CG  1 
ATOM   1730 C CD  . PRO A 1 278 ? 215.725 278.021 375.673 1.00 8.13  ? 278 PRO A CD  1 
ATOM   1731 N N   . TYR A 1 279 ? 220.134 278.107 373.928 1.00 14.10 ? 279 TYR A N   1 
ATOM   1732 C CA  . TYR A 1 279 ? 221.442 277.478 374.027 1.00 10.07 ? 279 TYR A CA  1 
ATOM   1733 C C   . TYR A 1 279 ? 222.023 277.684 375.419 1.00 10.43 ? 279 TYR A C   1 
ATOM   1734 O O   . TYR A 1 279 ? 221.800 278.710 376.065 1.00 15.97 ? 279 TYR A O   1 
ATOM   1735 C CB  . TYR A 1 279 ? 222.398 278.050 372.979 1.00 5.08  ? 279 TYR A CB  1 
ATOM   1736 C CG  . TYR A 1 279 ? 222.186 277.512 371.585 1.00 10.46 ? 279 TYR A CG  1 
ATOM   1737 C CD1 . TYR A 1 279 ? 222.441 276.179 371.288 1.00 6.37  ? 279 TYR A CD1 1 
ATOM   1738 C CD2 . TYR A 1 279 ? 221.738 278.336 370.562 1.00 8.53  ? 279 TYR A CD2 1 
ATOM   1739 C CE1 . TYR A 1 279 ? 222.256 275.684 370.016 1.00 4.32  ? 279 TYR A CE1 1 
ATOM   1740 C CE2 . TYR A 1 279 ? 221.550 277.849 369.286 1.00 8.72  ? 279 TYR A CE2 1 
ATOM   1741 C CZ  . TYR A 1 279 ? 221.808 276.523 369.019 1.00 5.99  ? 279 TYR A CZ  1 
ATOM   1742 O OH  . TYR A 1 279 ? 221.619 276.038 367.748 1.00 15.36 ? 279 TYR A OH  1 
ATOM   1743 N N   . TYR A 1 280 ? 222.771 276.685 375.886 1.00 14.40 ? 280 TYR A N   1 
ATOM   1744 C CA  . TYR A 1 280 ? 223.422 276.736 377.197 1.00 13.82 ? 280 TYR A CA  1 
ATOM   1745 C C   . TYR A 1 280 ? 224.794 276.078 377.057 1.00 13.24 ? 280 TYR A C   1 
ATOM   1746 O O   . TYR A 1 280 ? 224.930 274.860 377.202 1.00 15.95 ? 280 TYR A O   1 
ATOM   1747 C CB  . TYR A 1 280 ? 222.565 276.057 378.257 1.00 11.63 ? 280 TYR A CB  1 
ATOM   1748 C CG  . TYR A 1 280 ? 223.137 276.137 379.650 1.00 14.27 ? 280 TYR A CG  1 
ATOM   1749 C CD1 . TYR A 1 280 ? 223.237 277.353 380.309 1.00 15.40 ? 280 TYR A CD1 1 
ATOM   1750 C CD2 . TYR A 1 280 ? 223.566 274.996 380.313 1.00 16.07 ? 280 TYR A CD2 1 
ATOM   1751 C CE1 . TYR A 1 280 ? 223.754 277.434 381.585 1.00 19.23 ? 280 TYR A CE1 1 
ATOM   1752 C CE2 . TYR A 1 280 ? 224.087 275.066 381.590 1.00 17.97 ? 280 TYR A CE2 1 
ATOM   1753 C CZ  . TYR A 1 280 ? 224.177 276.288 382.221 1.00 19.52 ? 280 TYR A CZ  1 
ATOM   1754 O OH  . TYR A 1 280 ? 224.693 276.367 383.490 1.00 26.88 ? 280 TYR A OH  1 
ATOM   1755 N N   . GLY A 1 281 ? 225.807 276.894 376.783 1.00 12.02 ? 281 GLY A N   1 
ATOM   1756 C CA  . GLY A 1 281 ? 227.156 276.411 376.620 1.00 12.99 ? 281 GLY A CA  1 
ATOM   1757 C C   . GLY A 1 281 ? 227.452 275.965 375.202 1.00 10.26 ? 281 GLY A C   1 
ATOM   1758 O O   . GLY A 1 281 ? 226.581 275.970 374.329 1.00 10.95 ? 281 GLY A O   1 
ATOM   1759 N N   . PRO A 1 282 ? 228.702 275.567 374.948 1.00 15.79 ? 282 PRO A N   1 
ATOM   1760 C CA  . PRO A 1 282 ? 229.075 275.137 373.590 1.00 10.96 ? 282 PRO A CA  1 
ATOM   1761 C C   . PRO A 1 282 ? 228.441 273.824 373.168 1.00 12.04 ? 282 PRO A C   1 
ATOM   1762 O O   . PRO A 1 282 ? 228.423 273.526 371.969 1.00 14.06 ? 282 PRO A O   1 
ATOM   1763 C CB  . PRO A 1 282 ? 230.606 275.010 373.662 1.00 14.31 ? 282 PRO A CB  1 
ATOM   1764 C CG  . PRO A 1 282 ? 231.009 275.592 374.982 1.00 11.45 ? 282 PRO A CG  1 
ATOM   1765 C CD  . PRO A 1 282 ? 229.834 275.479 375.882 1.00 8.78  ? 282 PRO A CD  1 
ATOM   1766 N N   . GLY A 1 283 ? 227.936 273.027 374.102 1.00 9.83  ? 283 GLY A N   1 
ATOM   1767 C CA  . GLY A 1 283 ? 227.342 271.745 373.792 1.00 7.45  ? 283 GLY A CA  1 
ATOM   1768 C C   . GLY A 1 283 ? 225.860 271.845 373.500 1.00 11.23 ? 283 GLY A C   1 
ATOM   1769 O O   . GLY A 1 283 ? 225.340 272.895 373.118 1.00 17.36 ? 283 GLY A O   1 
ATOM   1770 N N   . VAL A 1 284 ? 225.170 270.719 373.687 1.00 10.96 ? 284 VAL A N   1 
ATOM   1771 C CA  . VAL A 1 284 ? 223.727 270.646 373.496 1.00 9.91  ? 284 VAL A CA  1 
ATOM   1772 C C   . VAL A 1 284 ? 222.972 270.785 374.815 1.00 8.78  ? 284 VAL A C   1 
ATOM   1773 O O   . VAL A 1 284 ? 221.761 270.558 374.857 1.00 14.29 ? 284 VAL A O   1 
ATOM   1774 C CB  . VAL A 1 284 ? 223.331 269.343 372.777 1.00 8.44  ? 284 VAL A CB  1 
ATOM   1775 C CG1 . VAL A 1 284 ? 224.099 269.201 371.465 1.00 5.06  ? 284 VAL A CG1 1 
ATOM   1776 C CG2 . VAL A 1 284 ? 223.562 268.131 373.678 1.00 4.67  ? 284 VAL A CG2 1 
ATOM   1777 N N   . ASP A 1 285 ? 223.656 271.173 375.887 1.00 7.48  ? 285 ASP A N   1 
ATOM   1778 C CA  . ASP A 1 285 ? 223.024 271.249 377.196 1.00 7.98  ? 285 ASP A CA  1 
ATOM   1779 C C   . ASP A 1 285 ? 221.916 272.298 377.206 1.00 10.21 ? 285 ASP A C   1 
ATOM   1780 O O   . ASP A 1 285 ? 221.952 273.284 376.467 1.00 12.81 ? 285 ASP A O   1 
ATOM   1781 C CB  . ASP A 1 285 ? 224.067 271.580 378.265 1.00 7.41  ? 285 ASP A CB  1 
ATOM   1782 C CG  . ASP A 1 285 ? 225.187 270.556 378.327 1.00 16.94 ? 285 ASP A CG  1 
ATOM   1783 O OD1 . ASP A 1 285 ? 224.890 269.345 378.317 1.00 15.73 ? 285 ASP A OD1 1 
ATOM   1784 O OD2 . ASP A 1 285 ? 226.365 270.961 378.377 1.00 19.50 ? 285 ASP A OD2 1 
ATOM   1785 N N   . TYR A 1 286 ? 220.915 272.067 378.052 1.00 6.78  ? 286 TYR A N   1 
ATOM   1786 C CA  . TYR A 1 286 ? 219.839 273.019 378.280 1.00 12.26 ? 286 TYR A CA  1 
ATOM   1787 C C   . TYR A 1 286 ? 219.568 273.107 379.774 1.00 10.47 ? 286 TYR A C   1 
ATOM   1788 O O   . TYR A 1 286 ? 219.697 272.119 380.498 1.00 19.26 ? 286 TYR A O   1 
ATOM   1789 C CB  . TYR A 1 286 ? 218.560 272.614 377.530 1.00 8.67  ? 286 TYR A CB  1 
ATOM   1790 C CG  . TYR A 1 286 ? 218.258 271.132 377.582 1.00 8.82  ? 286 TYR A CG  1 
ATOM   1791 C CD1 . TYR A 1 286 ? 217.932 270.509 378.778 1.00 9.66  ? 286 TYR A CD1 1 
ATOM   1792 C CD2 . TYR A 1 286 ? 218.290 270.358 376.431 1.00 10.01 ? 286 TYR A CD2 1 
ATOM   1793 C CE1 . TYR A 1 286 ? 217.654 269.155 378.827 1.00 13.49 ? 286 TYR A CE1 1 
ATOM   1794 C CE2 . TYR A 1 286 ? 218.011 269.005 376.470 1.00 7.27  ? 286 TYR A CE2 1 
ATOM   1795 C CZ  . TYR A 1 286 ? 217.692 268.410 377.670 1.00 7.34  ? 286 TYR A CZ  1 
ATOM   1796 O OH  . TYR A 1 286 ? 217.420 267.064 377.714 1.00 17.32 ? 286 TYR A OH  1 
ATOM   1797 N N   . LYS A 1 287 ? 219.234 274.311 380.240 1.00 18.51 ? 287 LYS A N   1 
ATOM   1798 C CA  . LYS A 1 287 ? 218.824 274.479 381.629 1.00 15.24 ? 287 LYS A CA  1 
ATOM   1799 C C   . LYS A 1 287 ? 217.508 275.241 381.749 1.00 16.50 ? 287 LYS A C   1 
ATOM   1800 O O   . LYS A 1 287 ? 216.636 274.858 382.534 1.00 24.96 ? 287 LYS A O   1 
ATOM   1801 C CB  . LYS A 1 287 ? 219.920 275.196 382.419 1.00 21.49 ? 287 LYS A CB  1 
ATOM   1802 C CG  . LYS A 1 287 ? 219.683 275.207 383.922 1.00 20.29 ? 287 LYS A CG  1 
ATOM   1803 C CD  . LYS A 1 287 ? 220.794 275.922 384.672 1.00 21.27 ? 287 LYS A CD  1 
ATOM   1804 C CE  . LYS A 1 287 ? 220.919 277.370 384.231 1.00 23.44 ? 287 LYS A CE  1 
ATOM   1805 N NZ  . LYS A 1 287 ? 221.696 278.184 385.201 1.00 27.52 ? 287 LYS A NZ  1 
ATOM   1806 N N   . ASP A 1 288 ? 217.342 276.297 380.959 1.00 19.14 ? 288 ASP A N   1 
ATOM   1807 C CA  . ASP A 1 288 ? 216.222 277.220 381.088 1.00 17.84 ? 288 ASP A CA  1 
ATOM   1808 C C   . ASP A 1 288 ? 215.400 277.259 379.806 1.00 17.83 ? 288 ASP A C   1 
ATOM   1809 O O   . ASP A 1 288 ? 215.832 276.811 378.742 1.00 20.14 ? 288 ASP A O   1 
ATOM   1810 C CB  . ASP A 1 288 ? 216.717 278.631 381.430 1.00 16.22 ? 288 ASP A CB  1 
ATOM   1811 C CG  . ASP A 1 288 ? 217.320 278.722 382.817 1.00 22.27 ? 288 ASP A CG  1 
ATOM   1812 O OD1 . ASP A 1 288 ? 217.443 277.676 383.486 1.00 28.47 ? 288 ASP A OD1 1 
ATOM   1813 O OD2 . ASP A 1 288 ? 217.669 279.843 383.240 1.00 28.44 ? 288 ASP A OD2 1 
ATOM   1814 N N   . GLY A 1 289 ? 214.196 277.816 379.925 1.00 16.20 ? 289 GLY A N   1 
ATOM   1815 C CA  . GLY A 1 289 ? 213.310 277.974 378.788 1.00 16.45 ? 289 GLY A CA  1 
ATOM   1816 C C   . GLY A 1 289 ? 212.947 276.661 378.129 1.00 14.45 ? 289 GLY A C   1 
ATOM   1817 O O   . GLY A 1 289 ? 213.008 276.540 376.903 1.00 20.67 ? 289 GLY A O   1 
ATOM   1818 N N   . LEU A 1 290 ? 212.564 275.670 378.928 1.00 13.36 ? 290 LEU A N   1 
ATOM   1819 C CA  . LEU A 1 290 ? 212.273 274.335 378.427 1.00 13.62 ? 290 LEU A CA  1 
ATOM   1820 C C   . LEU A 1 290 ? 210.817 274.159 378.017 1.00 15.98 ? 290 LEU A C   1 
ATOM   1821 O O   . LEU A 1 290 ? 210.392 273.029 377.763 1.00 22.73 ? 290 LEU A O   1 
ATOM   1822 C CB  . LEU A 1 290 ? 212.645 273.289 379.481 1.00 14.43 ? 290 LEU A CB  1 
ATOM   1823 C CG  . LEU A 1 290 ? 214.080 273.361 380.010 1.00 14.25 ? 290 LEU A CG  1 
ATOM   1824 C CD1 . LEU A 1 290 ? 214.347 272.218 380.970 1.00 18.08 ? 290 LEU A CD1 1 
ATOM   1825 C CD2 . LEU A 1 290 ? 215.088 273.354 378.869 1.00 16.06 ? 290 LEU A CD2 1 
ATOM   1826 N N   . ALA A 1 291 ? 210.046 275.245 377.937 1.00 19.51 ? 291 ALA A N   1 
ATOM   1827 C CA  . ALA A 1 291 ? 208.632 275.198 377.573 1.00 14.49 ? 291 ALA A CA  1 
ATOM   1828 C C   . ALA A 1 291 ? 208.375 276.177 376.431 1.00 12.77 ? 291 ALA A C   1 
ATOM   1829 O O   . ALA A 1 291 ? 207.706 277.202 376.613 1.00 19.26 ? 291 ALA A O   1 
ATOM   1830 C CB  . ALA A 1 291 ? 207.747 275.518 378.776 1.00 15.53 ? 291 ALA A CB  1 
ATOM   1831 N N   . PRO A 1 292 ? 208.892 275.884 375.234 1.00 14.02 ? 292 PRO A N   1 
ATOM   1832 C CA  . PRO A 1 292 ? 208.724 276.828 374.117 1.00 14.33 ? 292 PRO A CA  1 
ATOM   1833 C C   . PRO A 1 292 ? 207.311 276.885 373.554 1.00 13.48 ? 292 PRO A C   1 
ATOM   1834 O O   . PRO A 1 292 ? 206.913 277.937 373.041 1.00 20.65 ? 292 PRO A O   1 
ATOM   1835 C CB  . PRO A 1 292 ? 209.723 276.311 373.073 1.00 13.94 ? 292 PRO A CB  1 
ATOM   1836 C CG  . PRO A 1 292 ? 209.878 274.862 373.383 1.00 14.39 ? 292 PRO A CG  1 
ATOM   1837 C CD  . PRO A 1 292 ? 209.733 274.732 374.870 1.00 13.49 ? 292 PRO A CD  1 
ATOM   1838 N N   . LEU A 1 293 ? 206.546 275.798 373.616 1.00 13.28 ? 293 LEU A N   1 
ATOM   1839 C CA  . LEU A 1 293 ? 205.212 275.794 373.017 1.00 11.94 ? 293 LEU A CA  1 
ATOM   1840 C C   . LEU A 1 293 ? 204.247 276.618 373.866 1.00 14.48 ? 293 LEU A C   1 
ATOM   1841 O O   . LEU A 1 293 ? 204.227 276.465 375.090 1.00 22.70 ? 293 LEU A O   1 
ATOM   1842 C CB  . LEU A 1 293 ? 204.679 274.369 372.877 1.00 14.66 ? 293 LEU A CB  1 
ATOM   1843 C CG  . LEU A 1 293 ? 205.124 273.540 371.668 1.00 16.37 ? 293 LEU A CG  1 
ATOM   1844 C CD1 . LEU A 1 293 ? 204.705 274.205 370.360 1.00 19.54 ? 293 LEU A CD1 1 
ATOM   1845 C CD2 . LEU A 1 293 ? 206.619 273.296 371.696 1.00 16.49 ? 293 LEU A CD2 1 
ATOM   1846 N N   . PRO A 1 294 ? 203.441 277.490 373.263 1.00 16.33 ? 294 PRO A N   1 
ATOM   1847 C CA  . PRO A 1 294 ? 202.392 278.182 374.019 1.00 13.59 ? 294 PRO A CA  1 
ATOM   1848 C C   . PRO A 1 294 ? 201.139 277.323 374.149 1.00 13.78 ? 294 PRO A C   1 
ATOM   1849 O O   . PRO A 1 294 ? 201.043 276.219 373.613 1.00 18.01 ? 294 PRO A O   1 
ATOM   1850 C CB  . PRO A 1 294 ? 202.121 279.431 373.179 1.00 15.49 ? 294 PRO A CB  1 
ATOM   1851 C CG  . PRO A 1 294 ? 202.415 279.001 371.792 1.00 13.31 ? 294 PRO A CG  1 
ATOM   1852 C CD  . PRO A 1 294 ? 203.539 278.000 371.883 1.00 15.79 ? 294 PRO A CD  1 
ATOM   1853 N N   . GLU A 1 295 ? 200.164 277.863 374.875 1.00 17.72 ? 295 GLU A N   1 
ATOM   1854 C CA  . GLU A 1 295 ? 198.912 277.158 375.104 1.00 13.55 ? 295 GLU A CA  1 
ATOM   1855 C C   . GLU A 1 295 ? 197.919 277.479 373.993 1.00 14.32 ? 295 GLU A C   1 
ATOM   1856 O O   . GLU A 1 295 ? 197.797 278.632 373.569 1.00 24.61 ? 295 GLU A O   1 
ATOM   1857 C CB  . GLU A 1 295 ? 198.333 277.537 376.466 1.00 14.54 ? 295 GLU A CB  1 
ATOM   1858 C CG  . GLU A 1 295 ? 197.158 276.681 376.892 1.00 16.89 ? 295 GLU A CG  1 
ATOM   1859 C CD  . GLU A 1 295 ? 196.712 276.970 378.310 1.00 24.96 ? 295 GLU A CD  1 
ATOM   1860 O OE1 . GLU A 1 295 ? 197.570 276.968 379.218 1.00 26.26 ? 295 GLU A OE1 1 
ATOM   1861 O OE2 . GLU A 1 295 ? 195.504 277.209 378.518 1.00 28.36 ? 295 GLU A OE2 1 
ATOM   1862 N N   . LYS A 1 296 ? 197.217 276.453 373.515 1.00 18.37 ? 296 LYS A N   1 
ATOM   1863 C CA  . LYS A 1 296 ? 196.250 276.608 372.436 1.00 12.35 ? 296 LYS A CA  1 
ATOM   1864 C C   . LYS A 1 296 ? 195.248 275.465 372.508 1.00 16.86 ? 296 LYS A C   1 
ATOM   1865 O O   . LYS A 1 296 ? 195.641 274.304 372.653 1.00 16.39 ? 296 LYS A O   1 
ATOM   1866 C CB  . LYS A 1 296 ? 196.953 276.625 371.073 1.00 14.11 ? 296 LYS A CB  1 
ATOM   1867 C CG  . LYS A 1 296 ? 196.046 276.903 369.887 1.00 16.54 ? 296 LYS A CG  1 
ATOM   1868 C CD  . LYS A 1 296 ? 195.470 278.307 369.930 1.00 14.03 ? 296 LYS A CD  1 
ATOM   1869 C CE  . LYS A 1 296 ? 195.032 278.759 368.548 1.00 16.82 ? 296 LYS A CE  1 
ATOM   1870 N NZ  . LYS A 1 296 ? 194.286 280.042 368.578 1.00 18.56 ? 296 LYS A NZ  1 
ATOM   1871 N N   . GLY A 1 297 ? 193.963 275.797 372.407 1.00 13.47 ? 297 GLY A N   1 
ATOM   1872 C CA  . GLY A 1 297 ? 192.937 274.773 372.479 1.00 13.12 ? 297 GLY A CA  1 
ATOM   1873 C C   . GLY A 1 297 ? 193.012 273.807 371.312 1.00 12.15 ? 297 GLY A C   1 
ATOM   1874 O O   . GLY A 1 297 ? 193.381 274.168 370.193 1.00 11.94 ? 297 GLY A O   1 
ATOM   1875 N N   . LEU A 1 298 ? 192.643 272.553 371.586 1.00 14.94 ? 298 LEU A N   1 
ATOM   1876 C CA  . LEU A 1 298 ? 192.703 271.518 370.558 1.00 9.54  ? 298 LEU A CA  1 
ATOM   1877 C C   . LEU A 1 298 ? 191.753 271.822 369.405 1.00 9.71  ? 298 LEU A C   1 
ATOM   1878 O O   . LEU A 1 298 ? 192.055 271.513 368.247 1.00 10.61 ? 298 LEU A O   1 
ATOM   1879 C CB  . LEU A 1 298 ? 192.383 270.154 371.174 1.00 12.59 ? 298 LEU A CB  1 
ATOM   1880 C CG  . LEU A 1 298 ? 192.300 268.961 370.218 1.00 14.56 ? 298 LEU A CG  1 
ATOM   1881 C CD1 . LEU A 1 298 ? 193.573 268.824 369.400 1.00 9.49  ? 298 LEU A CD1 1 
ATOM   1882 C CD2 . LEU A 1 298 ? 192.016 267.684 370.994 1.00 12.95 ? 298 LEU A CD2 1 
ATOM   1883 N N   . THR A 1 299 ? 190.601 272.422 369.699 1.00 9.14  ? 299 THR A N   1 
ATOM   1884 C CA  . THR A 1 299 ? 189.598 272.737 368.689 1.00 12.99 ? 299 THR A CA  1 
ATOM   1885 C C   . THR A 1 299 ? 189.446 274.243 368.485 1.00 12.28 ? 299 THR A C   1 
ATOM   1886 O O   . THR A 1 299 ? 188.369 274.722 368.123 1.00 23.08 ? 299 THR A O   1 
ATOM   1887 C CB  . THR A 1 299 ? 188.256 272.107 369.059 1.00 12.77 ? 299 THR A CB  1 
ATOM   1888 O OG1 . THR A 1 299 ? 187.841 272.563 370.352 1.00 21.13 ? 299 THR A OG1 1 
ATOM   1889 C CG2 . THR A 1 299 ? 188.372 270.590 369.071 1.00 10.64 ? 299 THR A CG2 1 
ATOM   1890 N N   . THR A 1 300 ? 190.519 274.996 368.704 1.00 13.35 ? 300 THR A N   1 
ATOM   1891 C CA  . THR A 1 300 ? 190.536 276.439 368.505 1.00 11.58 ? 300 THR A CA  1 
ATOM   1892 C C   . THR A 1 300 ? 191.351 276.743 367.256 1.00 11.53 ? 300 THR A C   1 
ATOM   1893 O O   . THR A 1 300 ? 192.548 276.446 367.207 1.00 15.14 ? 300 THR A O   1 
ATOM   1894 C CB  . THR A 1 300 ? 191.128 277.155 369.720 1.00 15.56 ? 300 THR A CB  1 
ATOM   1895 O OG1 . THR A 1 300 ? 190.387 276.805 370.895 1.00 17.96 ? 300 THR A OG1 1 
ATOM   1896 C CG2 . THR A 1 300 ? 191.090 278.667 369.528 1.00 11.68 ? 300 THR A CG2 1 
ATOM   1897 N N   . TYR A 1 301 ? 190.709 277.339 366.258 1.00 9.25  ? 301 TYR A N   1 
ATOM   1898 C CA  . TYR A 1 301 ? 191.390 277.682 365.016 1.00 11.23 ? 301 TYR A CA  1 
ATOM   1899 C C   . TYR A 1 301 ? 192.434 278.771 365.246 1.00 16.70 ? 301 TYR A C   1 
ATOM   1900 O O   . TYR A 1 301 ? 193.409 278.876 364.506 1.00 20.98 ? 301 TYR A O   1 
ATOM   1901 C CB  . TYR A 1 301 ? 190.386 278.139 363.959 1.00 14.71 ? 301 TYR A CB  1 
ATOM   1902 C CG  . TYR A 1 301 ? 189.490 277.039 363.442 1.00 11.68 ? 301 TYR A CG  1 
ATOM   1903 C CD1 . TYR A 1 301 ? 189.942 276.144 362.481 1.00 13.60 ? 301 TYR A CD1 1 
ATOM   1904 C CD2 . TYR A 1 301 ? 188.191 276.899 363.907 1.00 8.51  ? 301 TYR A CD2 1 
ATOM   1905 C CE1 . TYR A 1 301 ? 189.124 275.141 361.999 1.00 10.93 ? 301 TYR A CE1 1 
ATOM   1906 C CE2 . TYR A 1 301 ? 187.368 275.898 363.433 1.00 11.77 ? 301 TYR A CE2 1 
ATOM   1907 C CZ  . TYR A 1 301 ? 187.840 275.022 362.478 1.00 9.88  ? 301 TYR A CZ  1 
ATOM   1908 O OH  . TYR A 1 301 ? 187.029 274.021 361.998 1.00 20.56 ? 301 TYR A OH  1 
ATOM   1909 O OXT . TYR A 1 301 ? 192.329 279.569 366.175 1.00 23.88 ? 301 TYR A OXT 1 
ATOM   1910 N N   . GLN B 2 84  ? 213.714 237.689 354.856 1.00 27.22 ? 84  GLN B N   1 
ATOM   1911 C CA  . GLN B 2 84  ? 214.755 236.994 355.604 1.00 26.35 ? 84  GLN B CA  1 
ATOM   1912 C C   . GLN B 2 84  ? 216.127 237.613 355.342 1.00 25.44 ? 84  GLN B C   1 
ATOM   1913 O O   . GLN B 2 84  ? 216.659 237.525 354.237 1.00 25.25 ? 84  GLN B O   1 
ATOM   1914 C CB  . GLN B 2 84  ? 214.765 235.510 355.242 1.00 23.00 ? 84  GLN B CB  1 
ATOM   1915 C CG  . GLN B 2 84  ? 215.837 234.707 355.950 1.00 23.80 ? 84  GLN B CG  1 
ATOM   1916 C CD  . GLN B 2 84  ? 215.621 233.215 355.816 1.00 28.51 ? 84  GLN B CD  1 
ATOM   1917 O OE1 . GLN B 2 84  ? 214.553 232.700 356.146 1.00 29.73 ? 84  GLN B OE1 1 
ATOM   1918 N NE2 . GLN B 2 84  ? 216.630 232.512 355.317 1.00 28.89 ? 84  GLN B NE2 1 
ATOM   1919 N N   . LEU B 2 85  ? 216.692 238.234 356.373 1.00 25.19 ? 85  LEU B N   1 
ATOM   1920 C CA  . LEU B 2 85  ? 217.963 238.942 356.286 1.00 21.41 ? 85  LEU B CA  1 
ATOM   1921 C C   . LEU B 2 85  ? 219.033 238.130 357.004 1.00 23.60 ? 85  LEU B C   1 
ATOM   1922 O O   . LEU B 2 85  ? 218.912 237.864 358.204 1.00 23.46 ? 85  LEU B O   1 
ATOM   1923 C CB  . LEU B 2 85  ? 217.837 240.337 356.898 1.00 19.52 ? 85  LEU B CB  1 
ATOM   1924 C CG  . LEU B 2 85  ? 219.116 241.160 357.047 1.00 21.33 ? 85  LEU B CG  1 
ATOM   1925 C CD1 . LEU B 2 85  ? 219.828 241.319 355.714 1.00 23.78 ? 85  LEU B CD1 1 
ATOM   1926 C CD2 . LEU B 2 85  ? 218.785 242.517 357.642 1.00 21.62 ? 85  LEU B CD2 1 
ATOM   1927 N N   . THR B 2 86  ? 220.077 237.746 356.275 1.00 19.63 ? 86  THR B N   1 
ATOM   1928 C CA  . THR B 2 86  ? 221.133 236.890 356.797 1.00 14.78 ? 86  THR B CA  1 
ATOM   1929 C C   . THR B 2 86  ? 222.466 237.621 356.744 1.00 15.72 ? 86  THR B C   1 
ATOM   1930 O O   . THR B 2 86  ? 222.816 238.210 355.716 1.00 20.92 ? 86  THR B O   1 
ATOM   1931 C CB  . THR B 2 86  ? 221.224 235.582 356.004 1.00 21.90 ? 86  THR B CB  1 
ATOM   1932 O OG1 . THR B 2 86  ? 219.971 234.890 356.070 1.00 28.18 ? 86  THR B OG1 1 
ATOM   1933 C CG2 . THR B 2 86  ? 222.322 234.688 356.563 1.00 20.20 ? 86  THR B CG2 1 
ATOM   1934 N N   . LEU B 2 87  ? 223.203 237.579 357.850 1.00 17.45 ? 87  LEU B N   1 
ATOM   1935 C CA  . LEU B 2 87  ? 224.559 238.112 357.917 1.00 18.86 ? 87  LEU B CA  1 
ATOM   1936 C C   . LEU B 2 87  ? 225.407 237.135 358.715 1.00 19.62 ? 87  LEU B C   1 
ATOM   1937 O O   . LEU B 2 87  ? 225.083 236.830 359.867 1.00 20.14 ? 87  LEU B O   1 
ATOM   1938 C CB  . LEU B 2 87  ? 224.586 239.502 358.561 1.00 13.87 ? 87  LEU B CB  1 
ATOM   1939 C CG  . LEU B 2 87  ? 223.846 240.615 357.816 1.00 22.12 ? 87  LEU B CG  1 
ATOM   1940 C CD1 . LEU B 2 87  ? 223.884 241.902 358.619 1.00 17.25 ? 87  LEU B CD1 1 
ATOM   1941 C CD2 . LEU B 2 87  ? 224.435 240.838 356.433 1.00 22.14 ? 87  LEU B CD2 1 
ATOM   1942 N N   . GLY B 2 88  ? 226.482 236.646 358.106 1.00 20.73 ? 88  GLY B N   1 
ATOM   1943 C CA  . GLY B 2 88  ? 227.303 235.656 358.779 1.00 20.30 ? 88  GLY B CA  1 
ATOM   1944 C C   . GLY B 2 88  ? 226.470 234.440 359.130 1.00 19.60 ? 88  GLY B C   1 
ATOM   1945 O O   . GLY B 2 88  ? 225.760 233.881 358.289 1.00 24.35 ? 88  GLY B O   1 
ATOM   1946 N N   . ASN B 2 89  ? 226.540 234.029 360.391 1.00 13.89 ? 89  ASN B N   1 
ATOM   1947 C CA  . ASN B 2 89  ? 225.779 232.883 360.870 1.00 17.33 ? 89  ASN B CA  1 
ATOM   1948 C C   . ASN B 2 89  ? 224.409 233.268 361.421 1.00 13.04 ? 89  ASN B C   1 
ATOM   1949 O O   . ASN B 2 89  ? 223.706 232.400 361.945 1.00 16.10 ? 89  ASN B O   1 
ATOM   1950 C CB  . ASN B 2 89  ? 226.577 232.130 361.945 1.00 11.59 ? 89  ASN B CB  1 
ATOM   1951 C CG  . ASN B 2 89  ? 226.763 232.934 363.223 1.00 14.80 ? 89  ASN B CG  1 
ATOM   1952 O OD1 . ASN B 2 89  ? 226.198 234.015 363.384 1.00 20.96 ? 89  ASN B OD1 1 
ATOM   1953 N ND2 . ASN B 2 89  ? 227.555 232.400 364.143 1.00 12.68 ? 89  ASN B ND2 1 
ATOM   1954 N N   . SER B 2 90  ? 224.011 234.532 361.315 1.00 17.48 ? 90  SER B N   1 
ATOM   1955 C CA  . SER B 2 90  ? 222.792 235.028 361.939 1.00 12.79 ? 90  SER B CA  1 
ATOM   1956 C C   . SER B 2 90  ? 221.729 235.300 360.882 1.00 14.28 ? 90  SER B C   1 
ATOM   1957 O O   . SER B 2 90  ? 222.038 235.776 359.787 1.00 23.09 ? 90  SER B O   1 
ATOM   1958 C CB  . SER B 2 90  ? 223.070 236.305 362.738 1.00 14.16 ? 90  SER B CB  1 
ATOM   1959 O OG  . SER B 2 90  ? 223.623 237.317 361.913 1.00 18.85 ? 90  SER B OG  1 
ATOM   1960 N N   . THR B 2 91  ? 220.478 234.985 361.213 1.00 18.49 ? 91  THR B N   1 
ATOM   1961 C CA  . THR B 2 91  ? 219.358 235.202 360.310 1.00 17.49 ? 91  THR B CA  1 
ATOM   1962 C C   . THR B 2 91  ? 218.187 235.795 361.079 1.00 18.30 ? 91  THR B C   1 
ATOM   1963 O O   . THR B 2 91  ? 217.929 235.416 362.224 1.00 21.94 ? 91  THR B O   1 
ATOM   1964 C CB  . THR B 2 91  ? 218.925 233.896 359.629 1.00 18.21 ? 91  THR B CB  1 
ATOM   1965 O OG1 . THR B 2 91  ? 220.025 233.348 358.893 1.00 30.43 ? 91  THR B OG1 1 
ATOM   1966 C CG2 . THR B 2 91  ? 217.755 234.143 358.686 1.00 20.24 ? 91  THR B CG2 1 
ATOM   1967 N N   . ILE B 2 92  ? 217.484 236.726 360.440 1.00 18.10 ? 92  ILE B N   1 
ATOM   1968 C CA  . ILE B 2 92  ? 216.297 237.361 360.999 1.00 20.57 ? 92  ILE B CA  1 
ATOM   1969 C C   . ILE B 2 92  ? 215.160 237.203 360.001 1.00 17.01 ? 92  ILE B C   1 
ATOM   1970 O O   . ILE B 2 92  ? 215.347 237.429 358.801 1.00 18.70 ? 92  ILE B O   1 
ATOM   1971 C CB  . ILE B 2 92  ? 216.539 238.848 361.318 1.00 18.26 ? 92  ILE B CB  1 
ATOM   1972 C CG1 . ILE B 2 92  ? 217.545 238.983 362.465 1.00 20.99 ? 92  ILE B CG1 1 
ATOM   1973 C CG2 . ILE B 2 92  ? 215.229 239.539 361.671 1.00 21.53 ? 92  ILE B CG2 1 
ATOM   1974 C CD1 . ILE B 2 92  ? 217.948 240.407 362.765 1.00 15.86 ? 92  ILE B CD1 1 
ATOM   1975 N N   . THR B 2 93  ? 213.990 236.810 360.493 1.00 24.20 ? 93  THR B N   1 
ATOM   1976 C CA  . THR B 2 93  ? 212.814 236.645 359.647 1.00 24.56 ? 93  THR B CA  1 
ATOM   1977 C C   . THR B 2 93  ? 211.613 237.369 360.242 1.00 26.25 ? 93  THR B C   1 
ATOM   1978 O O   . THR B 2 93  ? 211.423 237.380 361.460 1.00 32.24 ? 93  THR B O   1 
ATOM   1979 C CB  . THR B 2 93  ? 212.461 235.159 359.455 1.00 24.92 ? 93  THR B CB  1 
ATOM   1980 O OG1 . THR B 2 93  ? 212.253 234.545 360.732 1.00 30.39 ? 93  THR B OG1 1 
ATOM   1981 C CG2 . THR B 2 93  ? 213.576 234.434 358.724 1.00 25.63 ? 93  THR B CG2 1 
ATOM   1982 N N   . ASN B 2 99  ? 208.679 249.411 356.070 1.00 23.75 ? 99  ASN B N   1 
ATOM   1983 C CA  . ASN B 2 99  ? 209.129 248.498 357.115 1.00 23.93 ? 99  ASN B CA  1 
ATOM   1984 C C   . ASN B 2 99  ? 210.646 248.551 357.274 1.00 24.62 ? 99  ASN B C   1 
ATOM   1985 O O   . ASN B 2 99  ? 211.167 248.457 358.386 1.00 25.55 ? 99  ASN B O   1 
ATOM   1986 C CB  . ASN B 2 99  ? 208.686 247.069 356.800 1.00 21.83 ? 99  ASN B CB  1 
ATOM   1987 C CG  . ASN B 2 99  ? 209.417 246.482 355.609 1.00 26.79 ? 99  ASN B CG  1 
ATOM   1988 O OD1 . ASN B 2 99  ? 210.329 245.671 355.765 1.00 29.06 ? 99  ASN B OD1 1 
ATOM   1989 N ND2 . ASN B 2 99  ? 209.025 246.897 354.410 1.00 23.55 ? 99  ASN B ND2 1 
ATOM   1990 N N   . SER B 2 100 ? 211.350 248.699 356.154 1.00 22.57 ? 100 SER B N   1 
ATOM   1991 C CA  . SER B 2 100 ? 212.806 248.742 356.130 1.00 17.19 ? 100 SER B CA  1 
ATOM   1992 C C   . SER B 2 100 ? 213.250 250.075 355.550 1.00 19.28 ? 100 SER B C   1 
ATOM   1993 O O   . SER B 2 100 ? 212.770 250.486 354.488 1.00 29.20 ? 100 SER B O   1 
ATOM   1994 C CB  . SER B 2 100 ? 213.376 247.586 355.306 1.00 17.90 ? 100 SER B CB  1 
ATOM   1995 O OG  . SER B 2 100 ? 214.791 247.568 355.372 1.00 27.02 ? 100 SER B OG  1 
ATOM   1996 N N   . VAL B 2 101 ? 214.162 250.746 356.244 1.00 13.51 ? 101 VAL B N   1 
ATOM   1997 C CA  . VAL B 2 101 ? 214.612 252.080 355.871 1.00 12.49 ? 101 VAL B CA  1 
ATOM   1998 C C   . VAL B 2 101 ? 216.126 252.054 355.734 1.00 8.98  ? 101 VAL B C   1 
ATOM   1999 O O   . VAL B 2 101 ? 216.831 251.653 356.667 1.00 12.97 ? 101 VAL B O   1 
ATOM   2000 C CB  . VAL B 2 101 ? 214.180 253.139 356.900 1.00 9.39  ? 101 VAL B CB  1 
ATOM   2001 C CG1 . VAL B 2 101 ? 214.691 254.512 356.499 1.00 11.64 ? 101 VAL B CG1 1 
ATOM   2002 C CG2 . VAL B 2 101 ? 212.671 253.149 357.036 1.00 17.60 ? 101 VAL B CG2 1 
ATOM   2003 N N   . VAL B 2 102 ? 216.621 252.474 354.578 1.00 10.66 ? 102 VAL B N   1 
ATOM   2004 C CA  . VAL B 2 102 ? 218.044 252.692 354.357 1.00 7.41  ? 102 VAL B CA  1 
ATOM   2005 C C   . VAL B 2 102 ? 218.305 254.172 354.601 1.00 1.96  ? 102 VAL B C   1 
ATOM   2006 O O   . VAL B 2 102 ? 217.862 255.025 353.827 1.00 14.79 ? 102 VAL B O   1 
ATOM   2007 C CB  . VAL B 2 102 ? 218.472 252.269 352.946 1.00 9.37  ? 102 VAL B CB  1 
ATOM   2008 C CG1 . VAL B 2 102 ? 219.961 252.498 352.750 1.00 6.77  ? 102 VAL B CG1 1 
ATOM   2009 C CG2 . VAL B 2 102 ? 218.115 250.813 352.699 1.00 11.05 ? 102 VAL B CG2 1 
ATOM   2010 N N   . ALA B 2 103 ? 219.023 254.479 355.678 1.00 3.66  ? 103 ALA B N   1 
ATOM   2011 C CA  . ALA B 2 103 ? 219.259 255.867 356.053 1.00 3.06  ? 103 ALA B CA  1 
ATOM   2012 C C   . ALA B 2 103 ? 219.929 256.622 354.913 1.00 2.19  ? 103 ALA B C   1 
ATOM   2013 O O   . ALA B 2 103 ? 220.991 256.221 354.427 1.00 13.07 ? 103 ALA B O   1 
ATOM   2014 C CB  . ALA B 2 103 ? 220.120 255.927 357.312 1.00 4.11  ? 103 ALA B CB  1 
ATOM   2015 N N   . TYR B 2 104 ? 219.296 257.712 354.480 1.00 2.37  ? 104 TYR B N   1 
ATOM   2016 C CA  . TYR B 2 104 ? 219.814 258.579 353.426 1.00 5.35  ? 104 TYR B CA  1 
ATOM   2017 C C   . TYR B 2 104 ? 219.977 257.843 352.102 1.00 2.34  ? 104 TYR B C   1 
ATOM   2018 O O   . TYR B 2 104 ? 220.755 258.268 351.245 1.00 8.37  ? 104 TYR B O   1 
ATOM   2019 C CB  . TYR B 2 104 ? 221.143 259.213 353.854 1.00 4.00  ? 104 TYR B CB  1 
ATOM   2020 C CG  . TYR B 2 104 ? 221.056 259.914 355.189 1.00 2.66  ? 104 TYR B CG  1 
ATOM   2021 C CD1 . TYR B 2 104 ? 220.078 260.871 355.429 1.00 2.30  ? 104 TYR B CD1 1 
ATOM   2022 C CD2 . TYR B 2 104 ? 221.933 259.604 356.218 1.00 1.71  ? 104 TYR B CD2 1 
ATOM   2023 C CE1 . TYR B 2 104 ? 219.987 261.508 356.648 1.00 0.01  ? 104 TYR B CE1 1 
ATOM   2024 C CE2 . TYR B 2 104 ? 221.849 260.236 357.443 1.00 0.50  ? 104 TYR B CE2 1 
ATOM   2025 C CZ  . TYR B 2 104 ? 220.876 261.189 357.651 1.00 3.51  ? 104 TYR B CZ  1 
ATOM   2026 O OH  . TYR B 2 104 ? 220.792 261.817 358.867 1.00 10.98 ? 104 TYR B OH  1 
ATOM   2027 N N   . GLY B 2 105 ? 219.256 256.740 351.920 1.00 7.14  ? 105 GLY B N   1 
ATOM   2028 C CA  . GLY B 2 105 ? 219.352 255.977 350.689 1.00 5.51  ? 105 GLY B CA  1 
ATOM   2029 C C   . GLY B 2 105 ? 220.750 255.503 350.366 1.00 3.61  ? 105 GLY B C   1 
ATOM   2030 O O   . GLY B 2 105 ? 221.066 255.286 349.193 1.00 15.69 ? 105 GLY B O   1 
ATOM   2031 N N   . ARG B 2 106 ? 221.601 255.333 351.377 1.00 8.16  ? 106 ARG B N   1 
ATOM   2032 C CA  . ARG B 2 106 ? 222.997 254.948 351.187 1.00 8.11  ? 106 ARG B CA  1 
ATOM   2033 C C   . ARG B 2 106 ? 223.257 253.644 351.929 1.00 5.36  ? 106 ARG B C   1 
ATOM   2034 O O   . ARG B 2 106 ? 223.270 253.617 353.164 1.00 6.12  ? 106 ARG B O   1 
ATOM   2035 C CB  . ARG B 2 106 ? 223.936 256.052 351.675 1.00 10.46 ? 106 ARG B CB  1 
ATOM   2036 C CG  . ARG B 2 106 ? 224.030 257.246 350.735 1.00 11.54 ? 106 ARG B CG  1 
ATOM   2037 C CD  . ARG B 2 106 ? 224.922 256.953 349.540 1.00 10.29 ? 106 ARG B CD  1 
ATOM   2038 N NE  . ARG B 2 106 ? 226.300 256.703 349.945 1.00 9.10  ? 106 ARG B NE  1 
ATOM   2039 C CZ  . ARG B 2 106 ? 227.169 257.649 350.277 1.00 11.90 ? 106 ARG B CZ  1 
ATOM   2040 N NH1 . ARG B 2 106 ? 226.838 258.930 350.260 1.00 11.56 ? 106 ARG B NH1 1 
ATOM   2041 N NH2 . ARG B 2 106 ? 228.399 257.300 350.640 1.00 16.54 ? 106 ARG B NH2 1 
ATOM   2042 N N   . TRP B 2 107 ? 223.464 252.570 351.176 1.00 7.75  ? 107 TRP B N   1 
ATOM   2043 C CA  . TRP B 2 107 ? 223.834 251.301 351.776 1.00 10.89 ? 107 TRP B CA  1 
ATOM   2044 C C   . TRP B 2 107 ? 225.240 251.398 352.372 1.00 7.54  ? 107 TRP B C   1 
ATOM   2045 O O   . TRP B 2 107 ? 226.092 252.120 351.850 1.00 13.37 ? 107 TRP B O   1 
ATOM   2046 C CB  . TRP B 2 107 ? 223.786 250.190 350.730 1.00 9.75  ? 107 TRP B CB  1 
ATOM   2047 C CG  . TRP B 2 107 ? 223.652 248.820 351.308 1.00 18.14 ? 107 TRP B CG  1 
ATOM   2048 C CD1 . TRP B 2 107 ? 224.651 247.912 351.514 1.00 12.70 ? 107 TRP B CD1 1 
ATOM   2049 C CD2 . TRP B 2 107 ? 222.445 248.198 351.766 1.00 7.12  ? 107 TRP B CD2 1 
ATOM   2050 N NE1 . TRP B 2 107 ? 224.139 246.764 352.067 1.00 17.96 ? 107 TRP B NE1 1 
ATOM   2051 C CE2 . TRP B 2 107 ? 222.788 246.915 352.232 1.00 15.31 ? 107 TRP B CE2 1 
ATOM   2052 C CE3 . TRP B 2 107 ? 221.109 248.602 351.824 1.00 10.00 ? 107 TRP B CE3 1 
ATOM   2053 C CZ2 . TRP B 2 107 ? 221.842 246.033 352.750 1.00 12.73 ? 107 TRP B CZ2 1 
ATOM   2054 C CZ3 . TRP B 2 107 ? 220.173 247.725 352.337 1.00 14.13 ? 107 TRP B CZ3 1 
ATOM   2055 C CH2 . TRP B 2 107 ? 220.543 246.457 352.793 1.00 13.00 ? 107 TRP B CH2 1 
ATOM   2056 N N   . PRO B 2 108 ? 225.507 250.696 353.474 1.00 7.65  ? 108 PRO B N   1 
ATOM   2057 C CA  . PRO B 2 108 ? 226.876 250.673 354.000 1.00 11.22 ? 108 PRO B CA  1 
ATOM   2058 C C   . PRO B 2 108 ? 227.852 250.110 352.978 1.00 8.77  ? 108 PRO B C   1 
ATOM   2059 O O   . PRO B 2 108 ? 227.525 249.217 352.195 1.00 19.98 ? 108 PRO B O   1 
ATOM   2060 C CB  . PRO B 2 108 ? 226.774 249.779 355.243 1.00 10.24 ? 108 PRO B CB  1 
ATOM   2061 C CG  . PRO B 2 108 ? 225.432 249.131 355.178 1.00 9.91  ? 108 PRO B CG  1 
ATOM   2062 C CD  . PRO B 2 108 ? 224.561 250.036 354.388 1.00 10.04 ? 108 PRO B CD  1 
ATOM   2063 N N   . GLU B 2 109 ? 229.064 250.660 352.989 1.00 15.73 ? 109 GLU B N   1 
ATOM   2064 C CA  . GLU B 2 109 ? 230.076 250.319 352.002 1.00 12.10 ? 109 GLU B CA  1 
ATOM   2065 C C   . GLU B 2 109 ? 231.449 250.430 352.644 1.00 15.87 ? 109 GLU B C   1 
ATOM   2066 O O   . GLU B 2 109 ? 231.626 251.093 353.668 1.00 18.65 ? 109 GLU B O   1 
ATOM   2067 C CB  . GLU B 2 109 ? 229.987 251.235 350.776 1.00 15.09 ? 109 GLU B CB  1 
ATOM   2068 C CG  . GLU B 2 109 ? 230.287 252.694 351.087 1.00 21.90 ? 109 GLU B CG  1 
ATOM   2069 C CD  . GLU B 2 109 ? 229.910 253.634 349.956 1.00 24.99 ? 109 GLU B CD  1 
ATOM   2070 O OE1 . GLU B 2 109 ? 229.359 253.163 348.940 1.00 25.46 ? 109 GLU B OE1 1 
ATOM   2071 O OE2 . GLU B 2 109 ? 230.167 254.848 350.087 1.00 27.02 ? 109 GLU B OE2 1 
ATOM   2072 N N   . TYR B 2 110 ? 232.423 249.772 352.024 1.00 17.02 ? 110 TYR B N   1 
ATOM   2073 C CA  . TYR B 2 110 ? 233.799 249.856 352.481 1.00 17.44 ? 110 TYR B CA  1 
ATOM   2074 C C   . TYR B 2 110 ? 234.448 251.145 351.986 1.00 18.22 ? 110 TYR B C   1 
ATOM   2075 O O   . TYR B 2 110 ? 233.989 251.777 351.032 1.00 20.88 ? 110 TYR B O   1 
ATOM   2076 C CB  . TYR B 2 110 ? 234.605 248.651 351.998 1.00 14.67 ? 110 TYR B CB  1 
ATOM   2077 C CG  . TYR B 2 110 ? 234.157 247.340 352.597 1.00 15.37 ? 110 TYR B CG  1 
ATOM   2078 C CD1 . TYR B 2 110 ? 234.507 246.994 353.894 1.00 16.40 ? 110 TYR B CD1 1 
ATOM   2079 C CD2 . TYR B 2 110 ? 233.387 246.448 351.867 1.00 20.24 ? 110 TYR B CD2 1 
ATOM   2080 C CE1 . TYR B 2 110 ? 234.103 245.800 354.447 1.00 18.23 ? 110 TYR B CE1 1 
ATOM   2081 C CE2 . TYR B 2 110 ? 232.976 245.248 352.413 1.00 22.42 ? 110 TYR B CE2 1 
ATOM   2082 C CZ  . TYR B 2 110 ? 233.339 244.929 353.702 1.00 18.22 ? 110 TYR B CZ  1 
ATOM   2083 O OH  . TYR B 2 110 ? 232.936 243.739 354.255 1.00 26.68 ? 110 TYR B OH  1 
ATOM   2084 N N   . ILE B 2 111 ? 235.539 251.529 352.651 1.00 17.42 ? 111 ILE B N   1 
ATOM   2085 C CA  . ILE B 2 111 ? 236.266 252.724 352.247 1.00 19.22 ? 111 ILE B CA  1 
ATOM   2086 C C   . ILE B 2 111 ? 236.817 252.525 350.845 1.00 23.13 ? 111 ILE B C   1 
ATOM   2087 O O   . ILE B 2 111 ? 237.470 251.516 350.551 1.00 21.87 ? 111 ILE B O   1 
ATOM   2088 C CB  . ILE B 2 111 ? 237.394 253.036 353.240 1.00 20.28 ? 111 ILE B CB  1 
ATOM   2089 C CG1 . ILE B 2 111 ? 236.829 253.311 354.632 1.00 20.45 ? 111 ILE B CG1 1 
ATOM   2090 C CG2 . ILE B 2 111 ? 238.210 254.229 352.750 1.00 25.03 ? 111 ILE B CG2 1 
ATOM   2091 C CD1 . ILE B 2 111 ? 237.868 253.265 355.729 1.00 18.59 ? 111 ILE B CD1 1 
ATOM   2092 N N   . LYS B 2 112 ? 236.550 253.486 349.970 1.00 25.92 ? 112 LYS B N   1 
ATOM   2093 C CA  . LYS B 2 112 ? 237.161 253.482 348.652 1.00 29.51 ? 112 LYS B CA  1 
ATOM   2094 C C   . LYS B 2 112 ? 238.633 253.861 348.761 1.00 29.89 ? 112 LYS B C   1 
ATOM   2095 O O   . LYS B 2 112 ? 239.040 254.607 349.655 1.00 28.98 ? 112 LYS B O   1 
ATOM   2096 C CB  . LYS B 2 112 ? 236.443 254.461 347.726 1.00 27.92 ? 112 LYS B CB  1 
ATOM   2097 C CG  . LYS B 2 112 ? 234.937 254.284 347.673 1.00 29.08 ? 112 LYS B CG  1 
ATOM   2098 C CD  . LYS B 2 112 ? 234.287 255.430 346.924 1.00 29.91 ? 112 LYS B CD  1 
ATOM   2099 C CE  . LYS B 2 112 ? 232.779 255.406 347.071 1.00 32.56 ? 112 LYS B CE  1 
ATOM   2100 N NZ  . LYS B 2 112 ? 232.142 256.595 346.446 1.00 33.11 ? 112 LYS B NZ  1 
ATOM   2101 N N   . ASP B 2 113 ? 239.437 253.339 347.833 1.00 31.19 ? 113 ASP B N   1 
ATOM   2102 C CA  . ASP B 2 113 ? 240.857 253.677 347.830 1.00 32.02 ? 113 ASP B CA  1 
ATOM   2103 C C   . ASP B 2 113 ? 241.070 255.182 347.742 1.00 32.07 ? 113 ASP B C   1 
ATOM   2104 O O   . ASP B 2 113 ? 242.069 255.698 348.253 1.00 34.71 ? 113 ASP B O   1 
ATOM   2105 C CB  . ASP B 2 113 ? 241.566 252.970 346.674 1.00 33.11 ? 113 ASP B CB  1 
ATOM   2106 C CG  . ASP B 2 113 ? 241.808 251.498 346.948 1.00 36.41 ? 113 ASP B CG  1 
ATOM   2107 O OD1 . ASP B 2 113 ? 241.528 251.044 348.076 1.00 38.47 ? 113 ASP B OD1 1 
ATOM   2108 O OD2 . ASP B 2 113 ? 242.286 250.792 346.034 1.00 37.08 ? 113 ASP B OD2 1 
ATOM   2109 N N   . SER B 2 114 ? 240.139 255.903 347.115 1.00 31.99 ? 114 SER B N   1 
ATOM   2110 C CA  . SER B 2 114 ? 240.260 257.347 346.965 1.00 32.47 ? 114 SER B CA  1 
ATOM   2111 C C   . SER B 2 114 ? 239.846 258.118 348.212 1.00 31.97 ? 114 SER B C   1 
ATOM   2112 O O   . SER B 2 114 ? 240.026 259.339 348.246 1.00 31.68 ? 114 SER B O   1 
ATOM   2113 C CB  . SER B 2 114 ? 239.419 257.822 345.777 1.00 29.91 ? 114 SER B CB  1 
ATOM   2114 O OG  . SER B 2 114 ? 238.036 257.630 346.021 1.00 34.63 ? 114 SER B OG  1 
ATOM   2115 N N   . GLU B 2 115 ? 239.294 257.448 349.226 1.00 29.54 ? 115 GLU B N   1 
ATOM   2116 C CA  . GLU B 2 115 ? 238.899 258.102 350.470 1.00 26.58 ? 115 GLU B CA  1 
ATOM   2117 C C   . GLU B 2 115 ? 239.655 257.570 351.682 1.00 27.26 ? 115 GLU B C   1 
ATOM   2118 O O   . GLU B 2 115 ? 239.384 258.007 352.805 1.00 28.25 ? 115 GLU B O   1 
ATOM   2119 C CB  . GLU B 2 115 ? 237.392 257.948 350.700 1.00 24.87 ? 115 GLU B CB  1 
ATOM   2120 C CG  . GLU B 2 115 ? 236.525 258.591 349.628 1.00 26.12 ? 115 GLU B CG  1 
ATOM   2121 C CD  . GLU B 2 115 ? 235.064 258.685 350.035 1.00 29.83 ? 115 GLU B CD  1 
ATOM   2122 O OE1 . GLU B 2 115 ? 234.762 258.481 351.230 1.00 31.25 ? 115 GLU B OE1 1 
ATOM   2123 O OE2 . GLU B 2 115 ? 234.215 258.961 349.163 1.00 22.53 ? 115 GLU B OE2 1 
ATOM   2124 N N   . ALA B 2 116 ? 240.596 256.651 351.489 1.00 27.03 ? 116 ALA B N   1 
ATOM   2125 C CA  . ALA B 2 116 ? 241.265 255.997 352.607 1.00 29.65 ? 116 ALA B CA  1 
ATOM   2126 C C   . ALA B 2 116 ? 242.335 256.917 353.185 1.00 26.43 ? 116 ALA B C   1 
ATOM   2127 O O   . ALA B 2 116 ? 243.297 257.268 352.494 1.00 34.33 ? 116 ALA B O   1 
ATOM   2128 C CB  . ALA B 2 116 ? 241.878 254.677 352.149 1.00 27.79 ? 116 ALA B CB  1 
ATOM   2129 N N   . ASN B 2 117 ? 242.162 257.324 354.444 1.00 22.83 ? 117 ASN B N   1 
ATOM   2130 C CA  . ASN B 2 117 ? 243.175 258.130 355.115 1.00 20.68 ? 117 ASN B CA  1 
ATOM   2131 C C   . ASN B 2 117 ? 244.322 257.258 355.626 1.00 22.31 ? 117 ASN B C   1 
ATOM   2132 O O   . ASN B 2 117 ? 245.479 257.500 355.261 1.00 27.36 ? 117 ASN B O   1 
ATOM   2133 C CB  . ASN B 2 117 ? 242.554 258.938 356.259 1.00 20.64 ? 117 ASN B CB  1 
ATOM   2134 C CG  . ASN B 2 117 ? 243.543 259.891 356.904 1.00 22.00 ? 117 ASN B CG  1 
ATOM   2135 O OD1 . ASN B 2 117 ? 244.378 260.488 356.226 1.00 22.74 ? 117 ASN B OD1 1 
ATOM   2136 N ND2 . ASN B 2 117 ? 243.457 260.034 358.220 1.00 19.26 ? 117 ASN B ND2 1 
ATOM   2137 N N   . PRO B 2 118 ? 244.063 256.240 356.451 1.00 27.18 ? 118 PRO B N   1 
ATOM   2138 C CA  . PRO B 2 118 ? 245.166 255.403 356.938 1.00 22.90 ? 118 PRO B CA  1 
ATOM   2139 C C   . PRO B 2 118 ? 245.785 254.576 355.823 1.00 24.33 ? 118 PRO B C   1 
ATOM   2140 O O   . PRO B 2 118 ? 245.127 254.214 354.845 1.00 31.92 ? 118 PRO B O   1 
ATOM   2141 C CB  . PRO B 2 118 ? 244.501 254.510 357.993 1.00 21.00 ? 118 PRO B CB  1 
ATOM   2142 C CG  . PRO B 2 118 ? 243.081 254.458 357.601 1.00 20.88 ? 118 PRO B CG  1 
ATOM   2143 C CD  . PRO B 2 118 ? 242.770 255.805 357.014 1.00 22.46 ? 118 PRO B CD  1 
ATOM   2144 N N   . VAL B 2 119 ? 247.072 254.272 355.988 1.00 26.00 ? 119 VAL B N   1 
ATOM   2145 C CA  . VAL B 2 119 ? 247.829 253.576 354.953 1.00 23.47 ? 119 VAL B CA  1 
ATOM   2146 C C   . VAL B 2 119 ? 248.060 252.100 355.270 1.00 27.33 ? 119 VAL B C   1 
ATOM   2147 O O   . VAL B 2 119 ? 248.312 251.316 354.343 1.00 28.85 ? 119 VAL B O   1 
ATOM   2148 C CB  . VAL B 2 119 ? 249.181 254.278 354.701 1.00 23.40 ? 119 VAL B CB  1 
ATOM   2149 C CG1 . VAL B 2 119 ? 248.969 255.757 354.410 1.00 24.33 ? 119 VAL B CG1 1 
ATOM   2150 C CG2 . VAL B 2 119 ? 250.115 254.090 355.884 1.00 22.83 ? 119 VAL B CG2 1 
ATOM   2151 N N   . ASP B 2 120 ? 247.978 251.698 356.536 1.00 27.23 ? 120 ASP B N   1 
ATOM   2152 C CA  . ASP B 2 120 ? 248.178 250.298 356.879 1.00 27.82 ? 120 ASP B CA  1 
ATOM   2153 C C   . ASP B 2 120 ? 247.041 249.442 356.326 1.00 26.17 ? 120 ASP B C   1 
ATOM   2154 O O   . ASP B 2 120 ? 245.932 249.920 356.070 1.00 30.84 ? 120 ASP B O   1 
ATOM   2155 C CB  . ASP B 2 120 ? 248.276 250.123 358.395 1.00 25.17 ? 120 ASP B CB  1 
ATOM   2156 C CG  . ASP B 2 120 ? 246.995 250.503 359.111 1.00 28.29 ? 120 ASP B CG  1 
ATOM   2157 O OD1 . ASP B 2 120 ? 246.336 251.473 358.680 1.00 31.30 ? 120 ASP B OD1 1 
ATOM   2158 O OD2 . ASP B 2 120 ? 246.645 249.830 360.103 1.00 23.80 ? 120 ASP B OD2 1 
ATOM   2159 N N   . GLN B 2 121 ? 247.331 248.160 356.139 1.00 26.66 ? 121 GLN B N   1 
ATOM   2160 C CA  . GLN B 2 121 ? 246.333 247.232 355.624 1.00 29.86 ? 121 GLN B CA  1 
ATOM   2161 C C   . GLN B 2 121 ? 245.177 247.121 356.615 1.00 25.91 ? 121 GLN B C   1 
ATOM   2162 O O   . GLN B 2 121 ? 245.403 246.741 357.774 1.00 31.00 ? 121 GLN B O   1 
ATOM   2163 C CB  . GLN B 2 121 ? 246.963 245.860 355.380 1.00 28.55 ? 121 GLN B CB  1 
ATOM   2164 C CG  . GLN B 2 121 ? 245.968 244.731 355.113 1.00 28.91 ? 121 GLN B CG  1 
ATOM   2165 C CD  . GLN B 2 121 ? 245.083 244.991 353.909 1.00 31.53 ? 121 GLN B CD  1 
ATOM   2166 O OE1 . GLN B 2 121 ? 243.857 244.924 354.000 1.00 30.18 ? 121 GLN B OE1 1 
ATOM   2167 N NE2 . GLN B 2 121 ? 245.700 245.281 352.771 1.00 31.76 ? 121 GLN B NE2 1 
ATOM   2168 N N   . PRO B 2 122 ? 243.945 247.436 356.220 1.00 27.68 ? 122 PRO B N   1 
ATOM   2169 C CA  . PRO B 2 122 ? 242.823 247.310 357.156 1.00 23.41 ? 122 PRO B CA  1 
ATOM   2170 C C   . PRO B 2 122 ? 242.521 245.860 357.492 1.00 27.25 ? 122 PRO B C   1 
ATOM   2171 O O   . PRO B 2 122 ? 242.798 244.941 356.717 1.00 29.24 ? 122 PRO B O   1 
ATOM   2172 C CB  . PRO B 2 122 ? 241.651 247.954 356.403 1.00 23.64 ? 122 PRO B CB  1 
ATOM   2173 C CG  . PRO B 2 122 ? 242.267 248.780 355.346 1.00 29.35 ? 122 PRO B CG  1 
ATOM   2174 C CD  . PRO B 2 122 ? 243.535 248.092 354.968 1.00 28.09 ? 122 PRO B CD  1 
ATOM   2175 N N   . THR B 2 123 ? 241.943 245.669 358.672 1.00 27.88 ? 123 THR B N   1 
ATOM   2176 C CA  . THR B 2 123 ? 241.398 244.386 359.088 1.00 24.53 ? 123 THR B CA  1 
ATOM   2177 C C   . THR B 2 123 ? 239.910 244.362 358.768 1.00 22.50 ? 123 THR B C   1 
ATOM   2178 O O   . THR B 2 123 ? 239.181 245.297 359.116 1.00 21.48 ? 123 THR B O   1 
ATOM   2179 C CB  . THR B 2 123 ? 241.621 244.157 360.584 1.00 21.12 ? 123 THR B CB  1 
ATOM   2180 O OG1 . THR B 2 123 ? 243.020 244.248 360.878 1.00 28.14 ? 123 THR B OG1 1 
ATOM   2181 C CG2 . THR B 2 123 ? 241.095 242.794 361.007 1.00 23.81 ? 123 THR B CG2 1 
ATOM   2182 N N   . GLU B 2 124 ? 239.464 243.293 358.111 1.00 29.42 ? 124 GLU B N   1 
ATOM   2183 C CA  . GLU B 2 124 ? 238.069 243.128 357.705 1.00 24.30 ? 124 GLU B CA  1 
ATOM   2184 C C   . GLU B 2 124 ? 237.584 241.775 358.209 1.00 24.73 ? 124 GLU B C   1 
ATOM   2185 O O   . GLU B 2 124 ? 237.581 240.784 357.466 1.00 26.08 ? 124 GLU B O   1 
ATOM   2186 C CB  . GLU B 2 124 ? 237.920 243.258 356.189 1.00 23.78 ? 124 GLU B CB  1 
ATOM   2187 C CG  . GLU B 2 124 ? 238.215 244.658 355.677 1.00 26.74 ? 124 GLU B CG  1 
ATOM   2188 C CD  . GLU B 2 124 ? 238.145 244.764 354.168 1.00 33.12 ? 124 GLU B CD  1 
ATOM   2189 O OE1 . GLU B 2 124 ? 237.824 243.753 353.511 1.00 33.42 ? 124 GLU B OE1 1 
ATOM   2190 O OE2 . GLU B 2 124 ? 238.414 245.863 353.638 1.00 31.94 ? 124 GLU B OE2 1 
ATOM   2191 N N   . PRO B 2 125 ? 237.162 241.697 359.475 1.00 28.15 ? 125 PRO B N   1 
ATOM   2192 C CA  . PRO B 2 125 ? 236.758 240.394 360.034 1.00 22.02 ? 125 PRO B CA  1 
ATOM   2193 C C   . PRO B 2 125 ? 235.562 239.773 359.334 1.00 21.11 ? 125 PRO B C   1 
ATOM   2194 O O   . PRO B 2 125 ? 235.354 238.560 359.461 1.00 32.04 ? 125 PRO B O   1 
ATOM   2195 C CB  . PRO B 2 125 ? 236.445 240.722 361.500 1.00 22.83 ? 125 PRO B CB  1 
ATOM   2196 C CG  . PRO B 2 125 ? 236.141 242.182 361.513 1.00 25.22 ? 125 PRO B CG  1 
ATOM   2197 C CD  . PRO B 2 125 ? 236.985 242.795 360.440 1.00 21.44 ? 125 PRO B CD  1 
ATOM   2198 N N   . ASP B 2 126 ? 234.771 240.558 358.608 1.00 24.34 ? 126 ASP B N   1 
ATOM   2199 C CA  . ASP B 2 126 ? 233.646 240.055 357.808 1.00 22.64 ? 126 ASP B CA  1 
ATOM   2200 C C   . ASP B 2 126 ? 232.689 239.297 358.732 1.00 23.14 ? 126 ASP B C   1 
ATOM   2201 O O   . ASP B 2 126 ? 232.248 239.869 359.738 1.00 23.71 ? 126 ASP B O   1 
ATOM   2202 C CB  . ASP B 2 126 ? 234.213 239.257 356.642 1.00 24.67 ? 126 ASP B CB  1 
ATOM   2203 C CG  . ASP B 2 126 ? 233.162 238.897 355.614 1.00 27.25 ? 126 ASP B CG  1 
ATOM   2204 O OD1 . ASP B 2 126 ? 232.603 239.819 354.984 1.00 33.26 ? 126 ASP B OD1 1 
ATOM   2205 O OD2 . ASP B 2 126 ? 232.899 237.691 355.429 1.00 32.63 ? 126 ASP B OD2 1 
ATOM   2206 N N   . VAL B 2 127 ? 232.357 238.032 358.447 1.00 20.26 ? 127 VAL B N   1 
ATOM   2207 C CA  . VAL B 2 127 ? 231.236 237.374 359.122 1.00 22.71 ? 127 VAL B CA  1 
ATOM   2208 C C   . VAL B 2 127 ? 231.484 237.255 360.620 1.00 19.40 ? 127 VAL B C   1 
ATOM   2209 O O   . VAL B 2 127 ? 230.555 237.380 361.428 1.00 24.02 ? 127 VAL B O   1 
ATOM   2210 C CB  . VAL B 2 127 ? 230.957 235.993 358.492 1.00 24.96 ? 127 VAL B CB  1 
ATOM   2211 C CG1 . VAL B 2 127 ? 230.599 236.137 357.024 1.00 24.94 ? 127 VAL B CG1 1 
ATOM   2212 C CG2 . VAL B 2 127 ? 232.145 235.049 358.671 1.00 23.14 ? 127 VAL B CG2 1 
ATOM   2213 N N   . ALA B 2 128 ? 232.731 236.998 361.018 1.00 17.96 ? 128 ALA B N   1 
ATOM   2214 C CA  . ALA B 2 128 ? 233.018 236.785 362.433 1.00 20.00 ? 128 ALA B CA  1 
ATOM   2215 C C   . ALA B 2 128 ? 232.545 237.951 363.287 1.00 18.16 ? 128 ALA B C   1 
ATOM   2216 O O   . ALA B 2 128 ? 232.131 237.753 364.434 1.00 22.73 ? 128 ALA B O   1 
ATOM   2217 C CB  . ALA B 2 128 ? 234.514 236.558 362.639 1.00 18.56 ? 128 ALA B CB  1 
ATOM   2218 N N   . ALA B 2 129 ? 232.598 239.168 362.752 1.00 21.63 ? 129 ALA B N   1 
ATOM   2219 C CA  . ALA B 2 129 ? 232.119 240.347 363.457 1.00 17.91 ? 129 ALA B CA  1 
ATOM   2220 C C   . ALA B 2 129 ? 230.887 240.969 362.822 1.00 14.96 ? 129 ALA B C   1 
ATOM   2221 O O   . ALA B 2 129 ? 230.060 241.530 363.540 1.00 25.06 ? 129 ALA B O   1 
ATOM   2222 C CB  . ALA B 2 129 ? 233.228 241.405 363.537 1.00 16.89 ? 129 ALA B CB  1 
ATOM   2223 N N   . CYS B 2 130 ? 230.740 240.875 361.500 1.00 16.23 ? 130 CYS B N   1 
ATOM   2224 C CA  . CYS B 2 130 ? 229.584 241.432 360.797 1.00 16.03 ? 130 CYS B CA  1 
ATOM   2225 C C   . CYS B 2 130 ? 228.435 240.436 360.895 1.00 15.41 ? 130 CYS B C   1 
ATOM   2226 O O   . CYS B 2 130 ? 228.150 239.660 359.980 1.00 26.75 ? 130 CYS B O   1 
ATOM   2227 C CB  . CYS B 2 130 ? 229.929 241.740 359.346 1.00 21.32 ? 130 CYS B CB  1 
ATOM   2228 S SG  . CYS B 2 130 ? 231.234 242.962 359.132 1.00 35.91 ? 130 CYS B SG  1 
ATOM   2229 N N   . ARG B 2 131 ? 227.763 240.463 362.041 1.00 17.64 ? 131 ARG B N   1 
ATOM   2230 C CA  . ARG B 2 131 ? 226.671 239.543 362.312 1.00 12.57 ? 131 ARG B CA  1 
ATOM   2231 C C   . ARG B 2 131 ? 225.728 240.197 363.307 1.00 8.65  ? 131 ARG B C   1 
ATOM   2232 O O   . ARG B 2 131 ? 226.088 241.151 363.998 1.00 13.79 ? 131 ARG B O   1 
ATOM   2233 C CB  . ARG B 2 131 ? 227.189 238.206 362.854 1.00 11.60 ? 131 ARG B CB  1 
ATOM   2234 C CG  . ARG B 2 131 ? 227.955 238.328 364.163 1.00 10.75 ? 131 ARG B CG  1 
ATOM   2235 C CD  . ARG B 2 131 ? 228.471 236.983 364.646 1.00 11.23 ? 131 ARG B CD  1 
ATOM   2236 N NE  . ARG B 2 131 ? 227.402 236.007 364.822 1.00 13.62 ? 131 ARG B NE  1 
ATOM   2237 C CZ  . ARG B 2 131 ? 226.549 236.000 365.837 1.00 8.00  ? 131 ARG B CZ  1 
ATOM   2238 N NH1 . ARG B 2 131 ? 226.590 236.924 366.782 1.00 14.87 ? 131 ARG B NH1 1 
ATOM   2239 N NH2 . ARG B 2 131 ? 225.627 235.045 365.902 1.00 11.32 ? 131 ARG B NH2 1 
ATOM   2240 N N   . PHE B 2 132 ? 224.514 239.666 363.381 1.00 2.21  ? 132 PHE B N   1 
ATOM   2241 C CA  . PHE B 2 132 ? 223.521 240.216 364.290 1.00 6.85  ? 132 PHE B CA  1 
ATOM   2242 C C   . PHE B 2 132 ? 223.834 239.816 365.727 1.00 3.23  ? 132 PHE B C   1 
ATOM   2243 O O   . PHE B 2 132 ? 224.023 238.635 366.030 1.00 10.70 ? 132 PHE B O   1 
ATOM   2244 C CB  . PHE B 2 132 ? 222.125 239.743 363.889 1.00 7.05  ? 132 PHE B CB  1 
ATOM   2245 C CG  . PHE B 2 132 ? 221.590 240.426 362.661 1.00 10.42 ? 132 PHE B CG  1 
ATOM   2246 C CD1 . PHE B 2 132 ? 221.116 241.728 362.725 1.00 8.48  ? 132 PHE B CD1 1 
ATOM   2247 C CD2 . PHE B 2 132 ? 221.568 239.773 361.443 1.00 8.78  ? 132 PHE B CD2 1 
ATOM   2248 C CE1 . PHE B 2 132 ? 220.631 242.360 361.599 1.00 9.26  ? 132 PHE B CE1 1 
ATOM   2249 C CE2 . PHE B 2 132 ? 221.076 240.399 360.314 1.00 14.00 ? 132 PHE B CE2 1 
ATOM   2250 C CZ  . PHE B 2 132 ? 220.610 241.695 360.393 1.00 13.99 ? 132 PHE B CZ  1 
ATOM   2251 N N   . TYR B 2 133 ? 223.913 240.811 366.604 1.00 3.01  ? 133 TYR B N   1 
ATOM   2252 C CA  . TYR B 2 133 ? 224.007 240.619 368.040 1.00 7.14  ? 133 TYR B CA  1 
ATOM   2253 C C   . TYR B 2 133 ? 222.732 241.144 368.683 1.00 5.67  ? 133 TYR B C   1 
ATOM   2254 O O   . TYR B 2 133 ? 222.262 242.232 368.344 1.00 13.43 ? 133 TYR B O   1 
ATOM   2255 C CB  . TYR B 2 133 ? 225.219 241.352 368.623 1.00 10.85 ? 133 TYR B CB  1 
ATOM   2256 C CG  . TYR B 2 133 ? 226.547 240.968 368.012 1.00 8.25  ? 133 TYR B CG  1 
ATOM   2257 C CD1 . TYR B 2 133 ? 227.236 239.845 368.449 1.00 7.60  ? 133 TYR B CD1 1 
ATOM   2258 C CD2 . TYR B 2 133 ? 227.120 241.738 367.008 1.00 3.73  ? 133 TYR B CD2 1 
ATOM   2259 C CE1 . TYR B 2 133 ? 228.453 239.496 367.900 1.00 9.37  ? 133 TYR B CE1 1 
ATOM   2260 C CE2 . TYR B 2 133 ? 228.336 241.397 366.453 1.00 8.03  ? 133 TYR B CE2 1 
ATOM   2261 C CZ  . TYR B 2 133 ? 228.999 240.274 366.902 1.00 7.74  ? 133 TYR B CZ  1 
ATOM   2262 O OH  . TYR B 2 133 ? 230.208 239.927 366.354 1.00 15.28 ? 133 TYR B OH  1 
ATOM   2263 N N   . THR B 2 134 ? 222.180 240.380 369.615 1.00 13.31 ? 134 THR B N   1 
ATOM   2264 C CA  . THR B 2 134 ? 220.929 240.733 370.272 1.00 6.98  ? 134 THR B CA  1 
ATOM   2265 C C   . THR B 2 134 ? 221.242 241.353 371.627 1.00 9.29  ? 134 THR B C   1 
ATOM   2266 O O   . THR B 2 134 ? 221.838 240.702 372.491 1.00 15.78 ? 134 THR B O   1 
ATOM   2267 C CB  . THR B 2 134 ? 220.023 239.511 370.430 1.00 12.08 ? 134 THR B CB  1 
ATOM   2268 O OG1 . THR B 2 134 ? 219.647 239.021 369.138 1.00 13.57 ? 134 THR B OG1 1 
ATOM   2269 C CG2 . THR B 2 134 ? 218.766 239.870 371.216 1.00 7.01  ? 134 THR B CG2 1 
ATOM   2270 N N   . LEU B 2 135 ? 220.837 242.607 371.805 1.00 5.70  ? 135 LEU B N   1 
ATOM   2271 C CA  . LEU B 2 135 ? 221.057 243.310 373.056 1.00 7.12  ? 135 LEU B CA  1 
ATOM   2272 C C   . LEU B 2 135 ? 220.086 242.810 374.123 1.00 7.19  ? 135 LEU B C   1 
ATOM   2273 O O   . LEU B 2 135 ? 219.129 242.084 373.846 1.00 12.19 ? 135 LEU B O   1 
ATOM   2274 C CB  . LEU B 2 135 ? 220.888 244.817 372.858 1.00 12.09 ? 135 LEU B CB  1 
ATOM   2275 C CG  . LEU B 2 135 ? 222.021 245.582 372.165 1.00 10.00 ? 135 LEU B CG  1 
ATOM   2276 C CD1 . LEU B 2 135 ? 222.366 244.985 370.808 1.00 9.00  ? 135 LEU B CD1 1 
ATOM   2277 C CD2 . LEU B 2 135 ? 221.639 247.050 372.024 1.00 11.98 ? 135 LEU B CD2 1 
ATOM   2278 N N   . ASP B 2 136 ? 220.347 243.208 375.364 1.00 12.99 ? 136 ASP B N   1 
ATOM   2279 C CA  . ASP B 2 136 ? 219.418 242.908 376.442 1.00 13.17 ? 136 ASP B CA  1 
ATOM   2280 C C   . ASP B 2 136 ? 218.067 243.554 376.157 1.00 10.04 ? 136 ASP B C   1 
ATOM   2281 O O   . ASP B 2 136 ? 217.985 244.716 375.751 1.00 11.01 ? 136 ASP B O   1 
ATOM   2282 C CB  . ASP B 2 136 ? 219.971 243.398 377.780 1.00 11.88 ? 136 ASP B CB  1 
ATOM   2283 C CG  . ASP B 2 136 ? 221.233 242.663 378.198 1.00 21.09 ? 136 ASP B CG  1 
ATOM   2284 O OD1 . ASP B 2 136 ? 221.457 241.530 377.720 1.00 22.83 ? 136 ASP B OD1 1 
ATOM   2285 O OD2 . ASP B 2 136 ? 222.002 243.218 379.009 1.00 24.56 ? 136 ASP B OD2 1 
ATOM   2286 N N   . THR B 2 137 ? 217.005 242.786 376.368 1.00 12.36 ? 137 THR B N   1 
ATOM   2287 C CA  . THR B 2 137 ? 215.658 243.259 376.088 1.00 6.38  ? 137 THR B CA  1 
ATOM   2288 C C   . THR B 2 137 ? 215.207 244.264 377.143 1.00 7.07  ? 137 THR B C   1 
ATOM   2289 O O   . THR B 2 137 ? 215.453 244.085 378.338 1.00 17.99 ? 137 THR B O   1 
ATOM   2290 C CB  . THR B 2 137 ? 214.697 242.068 376.039 1.00 12.37 ? 137 THR B CB  1 
ATOM   2291 O OG1 . THR B 2 137 ? 214.985 241.269 374.886 1.00 12.92 ? 137 THR B OG1 1 
ATOM   2292 C CG2 . THR B 2 137 ? 213.251 242.520 375.990 1.00 5.90  ? 137 THR B CG2 1 
ATOM   2293 N N   . VAL B 2 138 ? 214.547 245.325 376.696 1.00 1.95  ? 138 VAL B N   1 
ATOM   2294 C CA  . VAL B 2 138 ? 213.983 246.323 377.591 1.00 9.38  ? 138 VAL B CA  1 
ATOM   2295 C C   . VAL B 2 138 ? 212.473 246.126 377.650 1.00 8.88  ? 138 VAL B C   1 
ATOM   2296 O O   . VAL B 2 138 ? 211.888 245.406 376.848 1.00 14.11 ? 138 VAL B O   1 
ATOM   2297 C CB  . VAL B 2 138 ? 214.349 247.768 377.159 1.00 8.83  ? 138 VAL B CB  1 
ATOM   2298 C CG1 . VAL B 2 138 ? 215.858 247.942 377.115 1.00 8.71  ? 138 VAL B CG1 1 
ATOM   2299 C CG2 . VAL B 2 138 ? 213.721 248.114 375.817 1.00 8.73  ? 138 VAL B CG2 1 
ATOM   2300 N N   . THR B 2 139 ? 211.828 246.769 378.617 1.00 8.90  ? 139 THR B N   1 
ATOM   2301 C CA  . THR B 2 139 ? 210.400 246.601 378.853 1.00 7.42  ? 139 THR B CA  1 
ATOM   2302 C C   . THR B 2 139 ? 209.678 247.913 378.572 1.00 9.45  ? 139 THR B C   1 
ATOM   2303 O O   . THR B 2 139 ? 209.990 248.942 379.182 1.00 6.75  ? 139 THR B O   1 
ATOM   2304 C CB  . THR B 2 139 ? 210.138 246.142 380.288 1.00 13.26 ? 139 THR B CB  1 
ATOM   2305 O OG1 . THR B 2 139 ? 210.820 244.906 380.528 1.00 19.53 ? 139 THR B OG1 1 
ATOM   2306 C CG2 . THR B 2 139 ? 208.652 245.948 380.528 1.00 11.40 ? 139 THR B CG2 1 
ATOM   2307 N N   . TRP B 2 140 ? 208.713 247.871 377.657 1.00 11.17 ? 140 TRP B N   1 
ATOM   2308 C CA  . TRP B 2 140 ? 207.845 249.001 377.367 1.00 6.99  ? 140 TRP B CA  1 
ATOM   2309 C C   . TRP B 2 140 ? 206.631 248.919 378.284 1.00 6.38  ? 140 TRP B C   1 
ATOM   2310 O O   . TRP B 2 140 ? 205.876 247.938 378.243 1.00 11.48 ? 140 TRP B O   1 
ATOM   2311 C CB  . TRP B 2 140 ? 207.431 248.979 375.896 1.00 3.00  ? 140 TRP B CB  1 
ATOM   2312 C CG  . TRP B 2 140 ? 206.569 250.126 375.440 1.00 7.80  ? 140 TRP B CG  1 
ATOM   2313 C CD1 . TRP B 2 140 ? 206.269 251.262 376.131 1.00 3.35  ? 140 TRP B CD1 1 
ATOM   2314 C CD2 . TRP B 2 140 ? 205.899 250.238 374.178 1.00 8.98  ? 140 TRP B CD2 1 
ATOM   2315 N NE1 . TRP B 2 140 ? 205.455 252.072 375.380 1.00 8.17  ? 140 TRP B NE1 1 
ATOM   2316 C CE2 . TRP B 2 140 ? 205.215 251.468 374.175 1.00 3.05  ? 140 TRP B CE2 1 
ATOM   2317 C CE3 . TRP B 2 140 ? 205.814 249.415 373.049 1.00 7.17  ? 140 TRP B CE3 1 
ATOM   2318 C CZ2 . TRP B 2 140 ? 204.451 251.894 373.090 1.00 2.20  ? 140 TRP B CZ2 1 
ATOM   2319 C CZ3 . TRP B 2 140 ? 205.055 249.840 371.974 1.00 5.87  ? 140 TRP B CZ3 1 
ATOM   2320 C CH2 . TRP B 2 140 ? 204.386 251.070 372.001 1.00 2.66  ? 140 TRP B CH2 1 
ATOM   2321 N N   . ARG B 2 141 ? 206.462 249.937 379.116 1.00 9.33  ? 141 ARG B N   1 
ATOM   2322 C CA  . ARG B 2 141 ? 205.333 250.067 380.021 1.00 13.47 ? 141 ARG B CA  1 
ATOM   2323 C C   . ARG B 2 141 ? 204.540 251.311 379.646 1.00 10.55 ? 141 ARG B C   1 
ATOM   2324 O O   . ARG B 2 141 ? 204.966 252.122 378.821 1.00 14.32 ? 141 ARG B O   1 
ATOM   2325 C CB  . ARG B 2 141 ? 205.799 250.156 381.479 1.00 11.68 ? 141 ARG B CB  1 
ATOM   2326 C CG  . ARG B 2 141 ? 206.792 249.086 381.879 1.00 15.26 ? 141 ARG B CG  1 
ATOM   2327 C CD  . ARG B 2 141 ? 207.284 249.290 383.300 1.00 14.38 ? 141 ARG B CD  1 
ATOM   2328 N NE  . ARG B 2 141 ? 208.261 248.278 383.683 1.00 18.39 ? 141 ARG B NE  1 
ATOM   2329 C CZ  . ARG B 2 141 ? 209.543 248.308 383.346 1.00 17.21 ? 141 ARG B CZ  1 
ATOM   2330 N NH1 . ARG B 2 141 ? 210.040 249.279 382.598 1.00 19.95 ? 141 ARG B NH1 1 
ATOM   2331 N NH2 . ARG B 2 141 ? 210.347 247.335 383.766 1.00 21.05 ? 141 ARG B NH2 1 
ATOM   2332 N N   . LYS B 2 142 ? 203.369 251.457 380.269 1.00 15.96 ? 142 LYS B N   1 
ATOM   2333 C CA  . LYS B 2 142 ? 202.571 252.656 380.047 1.00 16.24 ? 142 LYS B CA  1 
ATOM   2334 C C   . LYS B 2 142 ? 203.351 253.914 380.406 1.00 12.07 ? 142 LYS B C   1 
ATOM   2335 O O   . LYS B 2 142 ? 203.178 254.956 379.766 1.00 18.77 ? 142 LYS B O   1 
ATOM   2336 C CB  . LYS B 2 142 ? 201.273 252.584 380.855 1.00 15.28 ? 142 LYS B CB  1 
ATOM   2337 C CG  . LYS B 2 142 ? 200.337 251.455 380.435 1.00 23.15 ? 142 LYS B CG  1 
ATOM   2338 C CD  . LYS B 2 142 ? 199.002 251.493 381.179 1.00 23.40 ? 142 LYS B CD  1 
ATOM   2339 C CE  . LYS B 2 142 ? 198.192 252.745 380.857 1.00 21.71 ? 142 LYS B CE  1 
ATOM   2340 N NZ  . LYS B 2 142 ? 197.966 252.928 379.393 1.00 25.30 ? 142 LYS B NZ  1 
ATOM   2341 N N   . GLU B 2 143 ? 204.225 253.831 381.406 1.00 16.15 ? 143 GLU B N   1 
ATOM   2342 C CA  . GLU B 2 143 ? 204.968 254.980 381.906 1.00 15.05 ? 143 GLU B CA  1 
ATOM   2343 C C   . GLU B 2 143 ? 206.320 255.175 381.227 1.00 14.29 ? 143 GLU B C   1 
ATOM   2344 O O   . GLU B 2 143 ? 207.014 256.146 381.542 1.00 20.88 ? 143 GLU B O   1 
ATOM   2345 C CB  . GLU B 2 143 ? 205.182 254.846 383.419 1.00 14.61 ? 143 GLU B CB  1 
ATOM   2346 C CG  . GLU B 2 143 ? 203.900 254.696 384.232 1.00 23.03 ? 143 GLU B CG  1 
ATOM   2347 C CD  . GLU B 2 143 ? 203.301 253.299 384.153 1.00 24.10 ? 143 GLU B CD  1 
ATOM   2348 O OE1 . GLU B 2 143 ? 204.024 252.354 383.772 1.00 21.76 ? 143 GLU B OE1 1 
ATOM   2349 O OE2 . GLU B 2 143 ? 202.102 253.150 384.471 1.00 27.78 ? 143 GLU B OE2 1 
ATOM   2350 N N   . SER B 2 144 ? 206.714 254.290 380.313 1.00 13.54 ? 144 SER B N   1 
ATOM   2351 C CA  . SER B 2 144 ? 208.017 254.417 379.672 1.00 9.84  ? 144 SER B CA  1 
ATOM   2352 C C   . SER B 2 144 ? 208.108 255.732 378.908 1.00 6.53  ? 144 SER B C   1 
ATOM   2353 O O   . SER B 2 144 ? 207.179 256.114 378.192 1.00 13.96 ? 144 SER B O   1 
ATOM   2354 C CB  . SER B 2 144 ? 208.263 253.241 378.724 1.00 9.13  ? 144 SER B CB  1 
ATOM   2355 O OG  . SER B 2 144 ? 208.331 252.017 379.430 1.00 9.72  ? 144 SER B OG  1 
ATOM   2356 N N   . ARG B 2 145 ? 209.232 256.427 379.063 1.00 12.56 ? 145 ARG B N   1 
ATOM   2357 C CA  . ARG B 2 145 ? 209.473 257.665 378.334 1.00 11.09 ? 145 ARG B CA  1 
ATOM   2358 C C   . ARG B 2 145 ? 210.310 257.467 377.081 1.00 13.00 ? 145 ARG B C   1 
ATOM   2359 O O   . ARG B 2 145 ? 210.187 258.256 376.140 1.00 18.97 ? 145 ARG B O   1 
ATOM   2360 C CB  . ARG B 2 145 ? 210.162 258.694 379.238 1.00 12.39 ? 145 ARG B CB  1 
ATOM   2361 C CG  . ARG B 2 145 ? 209.358 259.094 380.467 1.00 15.54 ? 145 ARG B CG  1 
ATOM   2362 C CD  . ARG B 2 145 ? 207.924 259.444 380.110 1.00 15.52 ? 145 ARG B CD  1 
ATOM   2363 N NE  . ARG B 2 145 ? 207.274 260.245 381.142 1.00 24.33 ? 145 ARG B NE  1 
ATOM   2364 C CZ  . ARG B 2 145 ? 206.759 261.456 380.962 1.00 21.12 ? 145 ARG B CZ  1 
ATOM   2365 N NH1 . ARG B 2 145 ? 206.762 262.047 379.777 1.00 19.60 ? 145 ARG B NH1 1 
ATOM   2366 N NH2 . ARG B 2 145 ? 206.219 262.089 381.999 1.00 22.77 ? 145 ARG B NH2 1 
ATOM   2367 N N   . GLY B 2 146 ? 211.146 256.445 377.041 1.00 4.54  ? 146 GLY B N   1 
ATOM   2368 C CA  . GLY B 2 146 ? 211.967 256.182 375.875 1.00 7.28  ? 146 GLY B CA  1 
ATOM   2369 C C   . GLY B 2 146 ? 213.293 255.569 376.268 1.00 0.80  ? 146 GLY B C   1 
ATOM   2370 O O   . GLY B 2 146 ? 213.653 255.485 377.438 1.00 11.45 ? 146 GLY B O   1 
ATOM   2371 N N   . TRP B 2 147 ? 214.026 255.138 375.245 1.00 8.33  ? 147 TRP B N   1 
ATOM   2372 C CA  . TRP B 2 147 ? 215.302 254.463 375.414 1.00 5.02  ? 147 TRP B CA  1 
ATOM   2373 C C   . TRP B 2 147 ? 216.288 255.008 374.395 1.00 4.42  ? 147 TRP B C   1 
ATOM   2374 O O   . TRP B 2 147 ? 215.894 255.508 373.339 1.00 9.35  ? 147 TRP B O   1 
ATOM   2375 C CB  . TRP B 2 147 ? 215.160 252.944 375.242 1.00 3.29  ? 147 TRP B CB  1 
ATOM   2376 C CG  . TRP B 2 147 ? 214.110 252.344 376.122 1.00 4.33  ? 147 TRP B CG  1 
ATOM   2377 C CD1 . TRP B 2 147 ? 214.291 251.808 377.360 1.00 2.88  ? 147 TRP B CD1 1 
ATOM   2378 C CD2 . TRP B 2 147 ? 212.713 252.230 375.834 1.00 1.25  ? 147 TRP B CD2 1 
ATOM   2379 N NE1 . TRP B 2 147 ? 213.095 251.363 377.860 1.00 13.03 ? 147 TRP B NE1 1 
ATOM   2380 C CE2 . TRP B 2 147 ? 212.110 251.608 376.942 1.00 5.51  ? 147 TRP B CE2 1 
ATOM   2381 C CE3 . TRP B 2 147 ? 211.914 252.588 374.744 1.00 1.46  ? 147 TRP B CE3 1 
ATOM   2382 C CZ2 . TRP B 2 147 ? 210.744 251.340 376.996 1.00 5.75  ? 147 TRP B CZ2 1 
ATOM   2383 C CZ3 . TRP B 2 147 ? 210.560 252.320 374.799 1.00 4.67  ? 147 TRP B CZ3 1 
ATOM   2384 C CH2 . TRP B 2 147 ? 209.989 251.701 375.917 1.00 2.18  ? 147 TRP B CH2 1 
ATOM   2385 N N   . TRP B 2 148 ? 217.576 254.911 374.716 1.00 4.59  ? 148 TRP B N   1 
ATOM   2386 C CA  . TRP B 2 148 ? 218.604 255.329 373.777 1.00 4.95  ? 148 TRP B CA  1 
ATOM   2387 C C   . TRP B 2 148 ? 219.832 254.442 373.924 1.00 0.97  ? 148 TRP B C   1 
ATOM   2388 O O   . TRP B 2 148 ? 220.163 253.980 375.018 1.00 12.63 ? 148 TRP B O   1 
ATOM   2389 C CB  . TRP B 2 148 ? 218.984 256.808 373.958 1.00 0.57  ? 148 TRP B CB  1 
ATOM   2390 C CG  . TRP B 2 148 ? 219.536 257.159 375.303 1.00 0.96  ? 148 TRP B CG  1 
ATOM   2391 C CD1 . TRP B 2 148 ? 218.847 257.656 376.366 1.00 0.01  ? 148 TRP B CD1 1 
ATOM   2392 C CD2 . TRP B 2 148 ? 220.898 257.043 375.726 1.00 4.70  ? 148 TRP B CD2 1 
ATOM   2393 N NE1 . TRP B 2 148 ? 219.692 257.857 377.426 1.00 3.30  ? 148 TRP B NE1 1 
ATOM   2394 C CE2 . TRP B 2 148 ? 220.958 257.487 377.060 1.00 6.24  ? 148 TRP B CE2 1 
ATOM   2395 C CE3 . TRP B 2 148 ? 222.072 256.603 375.109 1.00 4.22  ? 148 TRP B CE3 1 
ATOM   2396 C CZ2 . TRP B 2 148 ? 222.145 257.505 377.788 1.00 1.39  ? 148 TRP B CZ2 1 
ATOM   2397 C CZ3 . TRP B 2 148 ? 223.250 256.622 375.834 1.00 11.74 ? 148 TRP B CZ3 1 
ATOM   2398 C CH2 . TRP B 2 148 ? 223.276 257.071 377.159 1.00 8.78  ? 148 TRP B CH2 1 
ATOM   2399 N N   . TRP B 2 149 ? 220.485 254.201 372.793 1.00 0.81  ? 149 TRP B N   1 
ATOM   2400 C CA  . TRP B 2 149 ? 221.746 253.483 372.718 1.00 0.95  ? 149 TRP B CA  1 
ATOM   2401 C C   . TRP B 2 149 ? 222.692 254.258 371.816 1.00 6.54  ? 149 TRP B C   1 
ATOM   2402 O O   . TRP B 2 149 ? 222.268 255.078 371.003 1.00 15.04 ? 149 TRP B O   1 
ATOM   2403 C CB  . TRP B 2 149 ? 221.577 252.063 372.163 1.00 2.08  ? 149 TRP B CB  1 
ATOM   2404 C CG  . TRP B 2 149 ? 220.710 251.179 372.990 1.00 8.77  ? 149 TRP B CG  1 
ATOM   2405 C CD1 . TRP B 2 149 ? 221.120 250.262 373.907 1.00 3.92  ? 149 TRP B CD1 1 
ATOM   2406 C CD2 . TRP B 2 149 ? 219.280 251.121 372.974 1.00 0.01  ? 149 TRP B CD2 1 
ATOM   2407 N NE1 . TRP B 2 149 ? 220.037 249.637 374.468 1.00 7.81  ? 149 TRP B NE1 1 
ATOM   2408 C CE2 . TRP B 2 149 ? 218.894 250.144 373.911 1.00 8.57  ? 149 TRP B CE2 1 
ATOM   2409 C CE3 . TRP B 2 149 ? 218.290 251.799 372.260 1.00 2.61  ? 149 TRP B CE3 1 
ATOM   2410 C CZ2 . TRP B 2 149 ? 217.560 249.830 374.155 1.00 4.04  ? 149 TRP B CZ2 1 
ATOM   2411 C CZ3 . TRP B 2 149 ? 216.966 251.485 372.502 1.00 10.68 ? 149 TRP B CZ3 1 
ATOM   2412 C CH2 . TRP B 2 149 ? 216.614 250.508 373.440 1.00 5.90  ? 149 TRP B CH2 1 
ATOM   2413 N N   . LYS B 2 150 ? 223.981 253.982 371.953 1.00 8.51  ? 150 LYS B N   1 
ATOM   2414 C CA  . LYS B 2 150 ? 224.991 254.558 371.082 1.00 7.07  ? 150 LYS B CA  1 
ATOM   2415 C C   . LYS B 2 150 ? 225.733 253.437 370.370 1.00 3.96  ? 150 LYS B C   1 
ATOM   2416 O O   . LYS B 2 150 ? 226.038 252.401 370.968 1.00 6.98  ? 150 LYS B O   1 
ATOM   2417 C CB  . LYS B 2 150 ? 225.974 255.436 371.868 1.00 8.54  ? 150 LYS B CB  1 
ATOM   2418 C CG  . LYS B 2 150 ? 225.318 256.557 372.662 1.00 7.08  ? 150 LYS B CG  1 
ATOM   2419 C CD  . LYS B 2 150 ? 224.519 257.492 371.767 1.00 10.42 ? 150 LYS B CD  1 
ATOM   2420 C CE  . LYS B 2 150 ? 224.033 258.721 372.523 1.00 11.36 ? 150 LYS B CE  1 
ATOM   2421 N NZ  . LYS B 2 150 ? 225.146 259.611 372.949 1.00 15.87 ? 150 LYS B NZ  1 
ATOM   2422 N N   . LEU B 2 151 ? 225.993 253.645 369.087 1.00 2.90  ? 151 LEU B N   1 
ATOM   2423 C CA  . LEU B 2 151 ? 226.745 252.739 368.249 1.00 3.58  ? 151 LEU B CA  1 
ATOM   2424 C C   . LEU B 2 151 ? 228.032 253.413 367.805 1.00 2.48  ? 151 LEU B C   1 
ATOM   2425 O O   . LEU B 2 151 ? 227.990 254.559 367.326 1.00 8.64  ? 151 LEU B O   1 
ATOM   2426 C CB  . LEU B 2 151 ? 225.925 252.328 367.025 1.00 9.80  ? 151 LEU B CB  1 
ATOM   2427 C CG  . LEU B 2 151 ? 224.609 251.611 367.325 1.00 5.88  ? 151 LEU B CG  1 
ATOM   2428 C CD1 . LEU B 2 151 ? 223.773 251.490 366.061 1.00 5.93  ? 151 LEU B CD1 1 
ATOM   2429 C CD2 . LEU B 2 151 ? 224.884 250.249 367.933 1.00 8.14  ? 151 LEU B CD2 1 
ATOM   2430 N N   . PRO B 2 152 ? 229.184 252.725 367.911 1.00 10.70 ? 152 PRO B N   1 
ATOM   2431 C CA  . PRO B 2 152 ? 229.353 251.302 368.264 1.00 4.37  ? 152 PRO B CA  1 
ATOM   2432 C C   . PRO B 2 152 ? 229.375 250.985 369.761 1.00 5.13  ? 152 PRO B C   1 
ATOM   2433 O O   . PRO B 2 152 ? 229.707 249.865 370.130 1.00 14.16 ? 152 PRO B O   1 
ATOM   2434 C CB  . PRO B 2 152 ? 230.707 250.964 367.629 1.00 6.17  ? 152 PRO B CB  1 
ATOM   2435 C CG  . PRO B 2 152 ? 231.486 252.238 367.745 1.00 10.30 ? 152 PRO B CG  1 
ATOM   2436 C CD  . PRO B 2 152 ? 230.476 253.355 367.581 1.00 5.16  ? 152 PRO B CD  1 
ATOM   2437 N N   . ASP B 2 153 ? 229.035 251.922 370.648 1.00 4.87  ? 153 ASP B N   1 
ATOM   2438 C CA  . ASP B 2 153 ? 229.169 251.663 372.079 1.00 10.02 ? 153 ASP B CA  1 
ATOM   2439 C C   . ASP B 2 153 ? 228.328 250.470 372.522 1.00 7.75  ? 153 ASP B C   1 
ATOM   2440 O O   . ASP B 2 153 ? 228.770 249.668 373.351 1.00 10.09 ? 153 ASP B O   1 
ATOM   2441 C CB  . ASP B 2 153 ? 228.775 252.898 372.884 1.00 3.76  ? 153 ASP B CB  1 
ATOM   2442 C CG  . ASP B 2 153 ? 228.600 252.593 374.358 1.00 11.80 ? 153 ASP B CG  1 
ATOM   2443 O OD1 . ASP B 2 153 ? 229.598 252.242 375.016 1.00 18.02 ? 153 ASP B OD1 1 
ATOM   2444 O OD2 . ASP B 2 153 ? 227.463 252.690 374.861 1.00 20.12 ? 153 ASP B OD2 1 
ATOM   2445 N N   . ALA B 2 154 ? 227.107 250.347 371.999 1.00 6.68  ? 154 ALA B N   1 
ATOM   2446 C CA  . ALA B 2 154 ? 226.224 249.273 372.434 1.00 5.99  ? 154 ALA B CA  1 
ATOM   2447 C C   . ALA B 2 154 ? 226.780 247.892 372.105 1.00 6.28  ? 154 ALA B C   1 
ATOM   2448 O O   . ALA B 2 154 ? 226.411 246.918 372.764 1.00 10.24 ? 154 ALA B O   1 
ATOM   2449 C CB  . ALA B 2 154 ? 224.842 249.440 371.802 1.00 6.61  ? 154 ALA B CB  1 
ATOM   2450 N N   . LEU B 2 155 ? 227.664 247.787 371.115 1.00 6.61  ? 155 LEU B N   1 
ATOM   2451 C CA  . LEU B 2 155 ? 228.216 246.510 370.686 1.00 5.05  ? 155 LEU B CA  1 
ATOM   2452 C C   . LEU B 2 155 ? 229.633 246.269 371.194 1.00 6.61  ? 155 LEU B C   1 
ATOM   2453 O O   . LEU B 2 155 ? 230.274 245.306 370.765 1.00 11.23 ? 155 LEU B O   1 
ATOM   2454 C CB  . LEU B 2 155 ? 228.195 246.423 369.160 1.00 4.47  ? 155 LEU B CB  1 
ATOM   2455 C CG  . LEU B 2 155 ? 226.833 246.614 368.488 1.00 8.54  ? 155 LEU B CG  1 
ATOM   2456 C CD1 . LEU B 2 155 ? 226.984 246.577 366.976 1.00 8.94  ? 155 LEU B CD1 1 
ATOM   2457 C CD2 . LEU B 2 155 ? 225.829 245.569 368.954 1.00 16.44 ? 155 LEU B CD2 1 
ATOM   2458 N N   . LYS B 2 156 ? 230.133 247.110 372.102 1.00 10.20 ? 156 LYS B N   1 
ATOM   2459 C CA  . LYS B 2 156 ? 231.537 247.028 372.491 1.00 13.10 ? 156 LYS B CA  1 
ATOM   2460 C C   . LYS B 2 156 ? 231.886 245.705 373.161 1.00 9.71  ? 156 LYS B C   1 
ATOM   2461 O O   . LYS B 2 156 ? 233.060 245.325 373.175 1.00 16.31 ? 156 LYS B O   1 
ATOM   2462 C CB  . LYS B 2 156 ? 231.894 248.191 373.419 1.00 10.05 ? 156 LYS B CB  1 
ATOM   2463 C CG  . LYS B 2 156 ? 231.222 248.145 374.776 1.00 11.50 ? 156 LYS B CG  1 
ATOM   2464 C CD  . LYS B 2 156 ? 231.430 249.443 375.534 1.00 10.20 ? 156 LYS B CD  1 
ATOM   2465 C CE  . LYS B 2 156 ? 230.740 249.411 376.884 1.00 13.06 ? 156 LYS B CE  1 
ATOM   2466 N NZ  . LYS B 2 156 ? 230.740 250.740 377.545 1.00 16.50 ? 156 LYS B NZ  1 
ATOM   2467 N N   . ASP B 2 157 ? 230.900 244.999 373.717 1.00 8.77  ? 157 ASP B N   1 
ATOM   2468 C CA  . ASP B 2 157 ? 231.116 243.710 374.362 1.00 6.88  ? 157 ASP B CA  1 
ATOM   2469 C C   . ASP B 2 157 ? 230.509 242.561 373.564 1.00 9.98  ? 157 ASP B C   1 
ATOM   2470 O O   . ASP B 2 157 ? 230.161 241.527 374.140 1.00 16.18 ? 157 ASP B O   1 
ATOM   2471 C CB  . ASP B 2 157 ? 230.545 243.731 375.781 1.00 10.86 ? 157 ASP B CB  1 
ATOM   2472 C CG  . ASP B 2 157 ? 231.210 244.771 376.664 1.00 23.37 ? 157 ASP B CG  1 
ATOM   2473 O OD1 . ASP B 2 157 ? 232.450 244.905 376.601 1.00 26.64 ? 157 ASP B OD1 1 
ATOM   2474 O OD2 . ASP B 2 157 ? 230.493 245.461 377.417 1.00 26.06 ? 157 ASP B OD2 1 
ATOM   2475 N N   . MET B 2 158 ? 230.372 242.724 372.249 1.00 7.54  ? 158 MET B N   1 
ATOM   2476 C CA  . MET B 2 158 ? 229.726 241.724 371.400 1.00 9.73  ? 158 MET B CA  1 
ATOM   2477 C C   . MET B 2 158 ? 230.797 240.918 370.679 1.00 9.66  ? 158 MET B C   1 
ATOM   2478 O O   . MET B 2 158 ? 231.134 241.181 369.524 1.00 13.93 ? 158 MET B O   1 
ATOM   2479 C CB  . MET B 2 158 ? 228.778 242.395 370.414 1.00 3.93  ? 158 MET B CB  1 
ATOM   2480 C CG  . MET B 2 158 ? 227.559 243.023 371.060 1.00 11.63 ? 158 MET B CG  1 
ATOM   2481 S SD  . MET B 2 158 ? 226.558 241.842 371.978 1.00 14.93 ? 158 MET B SD  1 
ATOM   2482 C CE  . MET B 2 158 ? 225.215 242.894 372.524 1.00 10.84 ? 158 MET B CE  1 
ATOM   2483 N N   . GLY B 2 159 ? 231.340 239.925 371.376 1.00 12.13 ? 159 GLY B N   1 
ATOM   2484 C CA  . GLY B 2 159 ? 232.252 238.968 370.783 1.00 10.37 ? 159 GLY B CA  1 
ATOM   2485 C C   . GLY B 2 159 ? 233.402 239.556 369.988 1.00 10.31 ? 159 GLY B C   1 
ATOM   2486 O O   . GLY B 2 159 ? 234.115 240.457 370.449 1.00 15.53 ? 159 GLY B O   1 
ATOM   2487 N N   . LEU B 2 160 ? 233.585 239.040 368.772 1.00 10.77 ? 160 LEU B N   1 
ATOM   2488 C CA  . LEU B 2 160 ? 234.750 239.419 367.983 1.00 13.75 ? 160 LEU B CA  1 
ATOM   2489 C C   . LEU B 2 160 ? 234.650 240.847 367.469 1.00 8.71  ? 160 LEU B C   1 
ATOM   2490 O O   . LEU B 2 160 ? 235.680 241.487 367.242 1.00 11.24 ? 160 LEU B O   1 
ATOM   2491 C CB  . LEU B 2 160 ? 234.946 238.441 366.826 1.00 13.96 ? 160 LEU B CB  1 
ATOM   2492 C CG  . LEU B 2 160 ? 235.635 237.127 367.209 1.00 12.49 ? 160 LEU B CG  1 
ATOM   2493 C CD1 . LEU B 2 160 ? 235.689 236.179 366.030 1.00 9.13  ? 160 LEU B CD1 1 
ATOM   2494 C CD2 . LEU B 2 160 ? 237.039 237.380 367.750 1.00 10.25 ? 160 LEU B CD2 1 
ATOM   2495 N N   . PHE B 2 161 ? 233.439 241.376 367.285 1.00 6.76  ? 161 PHE B N   1 
ATOM   2496 C CA  . PHE B 2 161 ? 233.329 242.788 366.941 1.00 10.33 ? 161 PHE B CA  1 
ATOM   2497 C C   . PHE B 2 161 ? 233.906 243.654 368.051 1.00 6.23  ? 161 PHE B C   1 
ATOM   2498 O O   . PHE B 2 161 ? 234.681 244.580 367.791 1.00 9.03  ? 161 PHE B O   1 
ATOM   2499 C CB  . PHE B 2 161 ? 231.879 243.181 366.669 1.00 8.69  ? 161 PHE B CB  1 
ATOM   2500 C CG  . PHE B 2 161 ? 231.717 244.638 366.344 1.00 3.20  ? 161 PHE B CG  1 
ATOM   2501 C CD1 . PHE B 2 161 ? 231.965 245.104 365.065 1.00 2.70  ? 161 PHE B CD1 1 
ATOM   2502 C CD2 . PHE B 2 161 ? 231.356 245.547 367.323 1.00 4.57  ? 161 PHE B CD2 1 
ATOM   2503 C CE1 . PHE B 2 161 ? 231.833 246.441 364.763 1.00 4.52  ? 161 PHE B CE1 1 
ATOM   2504 C CE2 . PHE B 2 161 ? 231.223 246.887 367.024 1.00 9.37  ? 161 PHE B CE2 1 
ATOM   2505 C CZ  . PHE B 2 161 ? 231.463 247.335 365.743 1.00 11.07 ? 161 PHE B CZ  1 
ATOM   2506 N N   . GLY B 2 162 ? 233.541 243.360 369.299 1.00 11.08 ? 162 GLY B N   1 
ATOM   2507 C CA  . GLY B 2 162 ? 234.107 244.097 370.415 1.00 8.60  ? 162 GLY B CA  1 
ATOM   2508 C C   . GLY B 2 162 ? 235.608 243.917 370.526 1.00 6.32  ? 162 GLY B C   1 
ATOM   2509 O O   . GLY B 2 162 ? 236.341 244.870 370.813 1.00 12.21 ? 162 GLY B O   1 
ATOM   2510 N N   . GLN B 2 163 ? 236.090 242.692 370.300 1.00 10.18 ? 163 GLN B N   1 
ATOM   2511 C CA  . GLN B 2 163 ? 237.530 242.460 370.352 1.00 10.46 ? 163 GLN B CA  1 
ATOM   2512 C C   . GLN B 2 163 ? 238.258 243.297 369.304 1.00 8.71  ? 163 GLN B C   1 
ATOM   2513 O O   . GLN B 2 163 ? 239.238 243.983 369.614 1.00 14.12 ? 163 GLN B O   1 
ATOM   2514 C CB  . GLN B 2 163 ? 237.832 240.971 370.170 1.00 12.19 ? 163 GLN B CB  1 
ATOM   2515 C CG  . GLN B 2 163 ? 237.363 240.103 371.326 1.00 6.27  ? 163 GLN B CG  1 
ATOM   2516 C CD  . GLN B 2 163 ? 237.960 240.525 372.653 1.00 8.22  ? 163 GLN B CD  1 
ATOM   2517 O OE1 . GLN B 2 163 ? 239.170 240.700 372.774 1.00 15.88 ? 163 GLN B OE1 1 
ATOM   2518 N NE2 . GLN B 2 163 ? 237.110 240.700 373.654 1.00 15.57 ? 163 GLN B NE2 1 
ATOM   2519 N N   . ASN B 2 164 ? 237.778 243.272 368.059 1.00 4.31  ? 164 ASN B N   1 
ATOM   2520 C CA  . ASN B 2 164 ? 238.413 244.061 367.008 1.00 9.33  ? 164 ASN B CA  1 
ATOM   2521 C C   . ASN B 2 164 ? 238.320 245.551 367.306 1.00 9.52  ? 164 ASN B C   1 
ATOM   2522 O O   . ASN B 2 164 ? 239.263 246.305 367.041 1.00 13.94 ? 164 ASN B O   1 
ATOM   2523 C CB  . ASN B 2 164 ? 237.777 243.746 365.656 1.00 6.21  ? 164 ASN B CB  1 
ATOM   2524 C CG  . ASN B 2 164 ? 238.316 242.469 365.046 1.00 10.94 ? 164 ASN B CG  1 
ATOM   2525 O OD1 . ASN B 2 164 ? 239.371 242.470 364.416 1.00 21.34 ? 164 ASN B OD1 1 
ATOM   2526 N ND2 . ASN B 2 164 ? 237.595 241.374 365.228 1.00 13.74 ? 164 ASN B ND2 1 
ATOM   2527 N N   . MET B 2 165 ? 237.191 245.993 367.859 1.00 5.18  ? 165 MET B N   1 
ATOM   2528 C CA  . MET B 2 165 ? 237.027 247.399 368.201 1.00 12.54 ? 165 MET B CA  1 
ATOM   2529 C C   . MET B 2 165 ? 238.063 247.841 369.226 1.00 7.51  ? 165 MET B C   1 
ATOM   2530 O O   . MET B 2 165 ? 238.669 248.909 369.084 1.00 12.85 ? 165 MET B O   1 
ATOM   2531 C CB  . MET B 2 165 ? 235.610 247.629 368.726 1.00 10.32 ? 165 MET B CB  1 
ATOM   2532 C CG  . MET B 2 165 ? 235.363 248.982 369.358 1.00 15.19 ? 165 MET B CG  1 
ATOM   2533 S SD  . MET B 2 165 ? 233.646 249.167 369.886 1.00 28.19 ? 165 MET B SD  1 
ATOM   2534 C CE  . MET B 2 165 ? 233.774 250.617 370.929 1.00 16.86 ? 165 MET B CE  1 
ATOM   2535 N N   . PHE B 2 166 ? 238.282 247.036 370.265 1.00 4.36  ? 166 PHE B N   1 
ATOM   2536 C CA  . PHE B 2 166 ? 239.211 247.443 371.314 1.00 10.96 ? 166 PHE B CA  1 
ATOM   2537 C C   . PHE B 2 166 ? 240.668 247.154 370.975 1.00 9.04  ? 166 PHE B C   1 
ATOM   2538 O O   . PHE B 2 166 ? 241.557 247.703 371.631 1.00 13.10 ? 166 PHE B O   1 
ATOM   2539 C CB  . PHE B 2 166 ? 238.848 246.767 372.637 1.00 10.69 ? 166 PHE B CB  1 
ATOM   2540 C CG  . PHE B 2 166 ? 237.642 247.359 373.304 1.00 12.84 ? 166 PHE B CG  1 
ATOM   2541 C CD1 . PHE B 2 166 ? 237.610 248.703 373.640 1.00 11.90 ? 166 PHE B CD1 1 
ATOM   2542 C CD2 . PHE B 2 166 ? 236.541 246.576 373.600 1.00 14.21 ? 166 PHE B CD2 1 
ATOM   2543 C CE1 . PHE B 2 166 ? 236.504 249.254 374.252 1.00 16.05 ? 166 PHE B CE1 1 
ATOM   2544 C CE2 . PHE B 2 166 ? 235.433 247.124 374.216 1.00 13.68 ? 166 PHE B CE2 1 
ATOM   2545 C CZ  . PHE B 2 166 ? 235.416 248.464 374.541 1.00 14.30 ? 166 PHE B CZ  1 
ATOM   2546 N N   . TYR B 2 167 ? 240.939 246.321 369.974 1.00 5.41  ? 167 TYR B N   1 
ATOM   2547 C CA  . TYR B 2 167 ? 242.313 246.040 369.579 1.00 6.29  ? 167 TYR B CA  1 
ATOM   2548 C C   . TYR B 2 167 ? 242.846 246.996 368.520 1.00 5.73  ? 167 TYR B C   1 
ATOM   2549 O O   . TYR B 2 167 ? 244.043 246.954 368.221 1.00 9.12  ? 167 TYR B O   1 
ATOM   2550 C CB  . TYR B 2 167 ? 242.435 244.603 369.061 1.00 6.20  ? 167 TYR B CB  1 
ATOM   2551 C CG  . TYR B 2 167 ? 242.876 243.621 370.118 1.00 9.09  ? 167 TYR B CG  1 
ATOM   2552 C CD1 . TYR B 2 167 ? 244.205 243.553 370.518 1.00 9.17  ? 167 TYR B CD1 1 
ATOM   2553 C CD2 . TYR B 2 167 ? 241.967 242.762 370.719 1.00 9.70  ? 167 TYR B CD2 1 
ATOM   2554 C CE1 . TYR B 2 167 ? 244.616 242.659 371.484 1.00 10.41 ? 167 TYR B CE1 1 
ATOM   2555 C CE2 . TYR B 2 167 ? 242.371 241.859 371.686 1.00 9.65  ? 167 TYR B CE2 1 
ATOM   2556 C CZ  . TYR B 2 167 ? 243.695 241.813 372.064 1.00 10.11 ? 167 TYR B CZ  1 
ATOM   2557 O OH  . TYR B 2 167 ? 244.098 240.921 373.028 1.00 20.11 ? 167 TYR B OH  1 
ATOM   2558 N N   . HIS B 2 168 ? 242.004 247.854 367.955 1.00 9.67  ? 168 HIS B N   1 
ATOM   2559 C CA  . HIS B 2 168 ? 242.395 248.724 366.858 1.00 11.56 ? 168 HIS B CA  1 
ATOM   2560 C C   . HIS B 2 168 ? 242.182 250.182 367.237 1.00 7.50  ? 168 HIS B C   1 
ATOM   2561 O O   . HIS B 2 168 ? 241.209 250.529 367.911 1.00 9.49  ? 168 HIS B O   1 
ATOM   2562 C CB  . HIS B 2 168 ? 241.609 248.396 365.590 1.00 5.32  ? 168 HIS B CB  1 
ATOM   2563 C CG  . HIS B 2 168 ? 242.013 247.106 364.948 1.00 12.15 ? 168 HIS B CG  1 
ATOM   2564 N ND1 . HIS B 2 168 ? 241.443 245.897 365.282 1.00 8.06  ? 168 HIS B ND1 1 
ATOM   2565 C CD2 . HIS B 2 168 ? 242.920 246.840 363.979 1.00 9.04  ? 168 HIS B CD2 1 
ATOM   2566 C CE1 . HIS B 2 168 ? 241.985 244.941 364.550 1.00 9.92  ? 168 HIS B CE1 1 
ATOM   2567 N NE2 . HIS B 2 168 ? 242.884 245.486 363.752 1.00 14.38 ? 168 HIS B NE2 1 
ATOM   2568 N N   . TYR B 2 169 ? 243.116 251.026 366.806 1.00 9.80  ? 169 TYR B N   1 
ATOM   2569 C CA  . TYR B 2 169 ? 242.971 252.465 366.989 1.00 7.75  ? 169 TYR B CA  1 
ATOM   2570 C C   . TYR B 2 169 ? 241.781 253.007 366.201 1.00 1.78  ? 169 TYR B C   1 
ATOM   2571 O O   . TYR B 2 169 ? 241.028 253.847 366.705 1.00 7.13  ? 169 TYR B O   1 
ATOM   2572 C CB  . TYR B 2 169 ? 244.282 253.146 366.588 1.00 13.04 ? 169 TYR B CB  1 
ATOM   2573 C CG  . TYR B 2 169 ? 244.214 254.620 366.253 1.00 9.88  ? 169 TYR B CG  1 
ATOM   2574 C CD1 . TYR B 2 169 ? 243.521 255.516 367.057 1.00 9.42  ? 169 TYR B CD1 1 
ATOM   2575 C CD2 . TYR B 2 169 ? 244.886 255.119 365.148 1.00 12.20 ? 169 TYR B CD2 1 
ATOM   2576 C CE1 . TYR B 2 169 ? 243.477 256.860 366.749 1.00 10.20 ? 169 TYR B CE1 1 
ATOM   2577 C CE2 . TYR B 2 169 ? 244.850 256.460 364.832 1.00 8.47  ? 169 TYR B CE2 1 
ATOM   2578 C CZ  . TYR B 2 169 ? 244.148 257.326 365.636 1.00 9.21  ? 169 TYR B CZ  1 
ATOM   2579 O OH  . TYR B 2 169 ? 244.115 258.662 365.317 1.00 24.49 ? 169 TYR B OH  1 
ATOM   2580 N N   . LEU B 2 170 ? 241.577 252.518 364.983 1.00 4.97  ? 170 LEU B N   1 
ATOM   2581 C CA  . LEU B 2 170 ? 240.571 253.042 364.071 1.00 9.68  ? 170 LEU B CA  1 
ATOM   2582 C C   . LEU B 2 170 ? 239.574 251.954 363.700 1.00 7.96  ? 170 LEU B C   1 
ATOM   2583 O O   . LEU B 2 170 ? 239.955 250.807 363.455 1.00 7.81  ? 170 LEU B O   1 
ATOM   2584 C CB  . LEU B 2 170 ? 241.220 253.597 362.800 1.00 5.25  ? 170 LEU B CB  1 
ATOM   2585 C CG  . LEU B 2 170 ? 242.213 254.742 363.004 1.00 10.01 ? 170 LEU B CG  1 
ATOM   2586 C CD1 . LEU B 2 170 ? 242.748 255.231 361.671 1.00 7.42  ? 170 LEU B CD1 1 
ATOM   2587 C CD2 . LEU B 2 170 ? 241.573 255.882 363.782 1.00 8.62  ? 170 LEU B CD2 1 
ATOM   2588 N N   . GLY B 2 171 ? 238.306 252.329 363.639 1.00 16.58 ? 171 GLY B N   1 
ATOM   2589 C CA  . GLY B 2 171 ? 237.261 251.402 363.245 1.00 10.98 ? 171 GLY B CA  1 
ATOM   2590 C C   . GLY B 2 171 ? 236.167 252.113 362.486 1.00 6.77  ? 171 GLY B C   1 
ATOM   2591 O O   . GLY B 2 171 ? 235.894 253.296 362.710 1.00 16.08 ? 171 GLY B O   1 
ATOM   2592 N N   . ARG B 2 172 ? 235.540 251.380 361.572 1.00 10.50 ? 172 ARG B N   1 
ATOM   2593 C CA  . ARG B 2 172 ? 234.461 251.889 360.742 1.00 10.55 ? 172 ARG B CA  1 
ATOM   2594 C C   . ARG B 2 172 ? 233.444 250.779 360.530 1.00 7.79  ? 172 ARG B C   1 
ATOM   2595 O O   . ARG B 2 172 ? 233.816 249.641 360.234 1.00 8.19  ? 172 ARG B O   1 
ATOM   2596 C CB  . ARG B 2 172 ? 234.996 252.382 359.391 1.00 9.84  ? 172 ARG B CB  1 
ATOM   2597 C CG  . ARG B 2 172 ? 233.941 252.751 358.368 1.00 10.61 ? 172 ARG B CG  1 
ATOM   2598 C CD  . ARG B 2 172 ? 234.564 252.882 356.995 1.00 12.82 ? 172 ARG B CD  1 
ATOM   2599 N NE  . ARG B 2 172 ? 233.567 252.993 355.938 1.00 12.24 ? 172 ARG B NE  1 
ATOM   2600 C CZ  . ARG B 2 172 ? 233.284 254.101 355.267 1.00 11.26 ? 172 ARG B CZ  1 
ATOM   2601 N NH1 . ARG B 2 172 ? 233.901 255.244 355.518 1.00 10.93 ? 172 ARG B NH1 1 
ATOM   2602 N NH2 . ARG B 2 172 ? 232.363 254.058 354.310 1.00 17.68 ? 172 ARG B NH2 1 
ATOM   2603 N N   . ALA B 2 173 ? 232.165 251.115 360.671 1.00 6.60  ? 173 ALA B N   1 
ATOM   2604 C CA  . ALA B 2 173 ? 231.107 250.144 360.431 1.00 6.94  ? 173 ALA B CA  1 
ATOM   2605 C C   . ALA B 2 173 ? 229.785 250.862 360.218 1.00 2.53  ? 173 ALA B C   1 
ATOM   2606 O O   . ALA B 2 173 ? 229.491 251.849 360.895 1.00 13.73 ? 173 ALA B O   1 
ATOM   2607 C CB  . ALA B 2 173 ? 230.977 249.158 361.597 1.00 4.09  ? 173 ALA B CB  1 
ATOM   2608 N N   . GLY B 2 174 ? 229.001 250.361 359.271 1.00 9.38  ? 174 GLY B N   1 
ATOM   2609 C CA  . GLY B 2 174 ? 227.581 250.624 359.234 1.00 6.27  ? 174 GLY B CA  1 
ATOM   2610 C C   . GLY B 2 174 ? 226.857 249.660 360.153 1.00 2.91  ? 174 GLY B C   1 
ATOM   2611 O O   . GLY B 2 174 ? 227.462 248.853 360.857 1.00 3.07  ? 174 GLY B O   1 
ATOM   2612 N N   . TYR B 2 175 ? 225.530 249.729 360.125 1.00 4.66  ? 175 TYR B N   1 
ATOM   2613 C CA  . TYR B 2 175 ? 224.738 248.862 360.984 1.00 10.06 ? 175 TYR B CA  1 
ATOM   2614 C C   . TYR B 2 175 ? 223.427 248.487 360.311 1.00 6.20  ? 175 TYR B C   1 
ATOM   2615 O O   . TYR B 2 175 ? 222.932 249.192 359.433 1.00 7.63  ? 175 TYR B O   1 
ATOM   2616 C CB  . TYR B 2 175 ? 224.454 249.523 362.338 1.00 1.36  ? 175 TYR B CB  1 
ATOM   2617 C CG  . TYR B 2 175 ? 225.702 249.986 363.048 1.00 6.19  ? 175 TYR B CG  1 
ATOM   2618 C CD1 . TYR B 2 175 ? 226.432 249.118 363.849 1.00 5.87  ? 175 TYR B CD1 1 
ATOM   2619 C CD2 . TYR B 2 175 ? 226.161 251.287 362.901 1.00 6.03  ? 175 TYR B CD2 1 
ATOM   2620 C CE1 . TYR B 2 175 ? 227.578 249.540 364.492 1.00 4.90  ? 175 TYR B CE1 1 
ATOM   2621 C CE2 . TYR B 2 175 ? 227.301 251.716 363.537 1.00 5.79  ? 175 TYR B CE2 1 
ATOM   2622 C CZ  . TYR B 2 175 ? 228.009 250.840 364.331 1.00 8.79  ? 175 TYR B CZ  1 
ATOM   2623 O OH  . TYR B 2 175 ? 229.143 251.276 364.964 1.00 15.90 ? 175 TYR B OH  1 
ATOM   2624 N N   . THR B 2 176 ? 222.893 247.344 360.720 1.00 5.85  ? 176 THR B N   1 
ATOM   2625 C CA  . THR B 2 176 ? 221.498 246.983 360.500 1.00 7.27  ? 176 THR B CA  1 
ATOM   2626 C C   . THR B 2 176 ? 220.871 246.859 361.880 1.00 5.24  ? 176 THR B C   1 
ATOM   2627 O O   . THR B 2 176 ? 221.245 245.973 362.654 1.00 13.76 ? 176 THR B O   1 
ATOM   2628 C CB  . THR B 2 176 ? 221.362 245.681 359.710 1.00 6.44  ? 176 THR B CB  1 
ATOM   2629 O OG1 . THR B 2 176 ? 222.057 245.791 358.465 1.00 7.09  ? 176 THR B OG1 1 
ATOM   2630 C CG2 . THR B 2 176 ? 219.900 245.370 359.441 1.00 5.23  ? 176 THR B CG2 1 
ATOM   2631 N N   . VAL B 2 177 ? 219.949 247.761 362.197 1.00 2.97  ? 177 VAL B N   1 
ATOM   2632 C CA  . VAL B 2 177 ? 219.257 247.778 363.478 1.00 8.09  ? 177 VAL B CA  1 
ATOM   2633 C C   . VAL B 2 177 ? 217.866 247.201 363.272 1.00 3.39  ? 177 VAL B C   1 
ATOM   2634 O O   . VAL B 2 177 ? 217.109 247.677 362.418 1.00 10.98 ? 177 VAL B O   1 
ATOM   2635 C CB  . VAL B 2 177 ? 219.180 249.202 364.054 1.00 6.04  ? 177 VAL B CB  1 
ATOM   2636 C CG1 . VAL B 2 177 ? 218.420 249.202 365.371 1.00 6.04  ? 177 VAL B CG1 1 
ATOM   2637 C CG2 . VAL B 2 177 ? 220.577 249.789 364.231 1.00 7.94  ? 177 VAL B CG2 1 
ATOM   2638 N N   . HIS B 2 178 ? 217.526 246.185 364.053 1.00 3.28  ? 178 HIS B N   1 
ATOM   2639 C CA  . HIS B 2 178 ? 216.245 245.497 363.963 1.00 5.05  ? 178 HIS B CA  1 
ATOM   2640 C C   . HIS B 2 178 ? 215.593 245.589 365.337 1.00 4.52  ? 178 HIS B C   1 
ATOM   2641 O O   . HIS B 2 178 ? 215.999 244.896 366.275 1.00 14.90 ? 178 HIS B O   1 
ATOM   2642 C CB  . HIS B 2 178 ? 216.440 244.050 363.518 1.00 5.65  ? 178 HIS B CB  1 
ATOM   2643 C CG  . HIS B 2 178 ? 215.166 243.330 363.206 1.00 11.36 ? 178 HIS B CG  1 
ATOM   2644 N ND1 . HIS B 2 178 ? 214.313 243.727 362.199 1.00 14.19 ? 178 HIS B ND1 1 
ATOM   2645 C CD2 . HIS B 2 178 ? 214.603 242.234 363.765 1.00 8.75  ? 178 HIS B CD2 1 
ATOM   2646 C CE1 . HIS B 2 178 ? 213.279 242.907 362.153 1.00 9.35  ? 178 HIS B CE1 1 
ATOM   2647 N NE2 . HIS B 2 178 ? 213.430 241.993 363.093 1.00 14.55 ? 178 HIS B NE2 1 
ATOM   2648 N N   . VAL B 2 179 ? 214.606 246.462 365.456 1.00 8.69  ? 179 VAL B N   1 
ATOM   2649 C CA  . VAL B 2 179 ? 213.829 246.605 366.678 1.00 5.02  ? 179 VAL B CA  1 
ATOM   2650 C C   . VAL B 2 179 ? 212.636 245.668 366.586 1.00 7.23  ? 179 VAL B C   1 
ATOM   2651 O O   . VAL B 2 179 ? 211.901 245.685 365.594 1.00 10.33 ? 179 VAL B O   1 
ATOM   2652 C CB  . VAL B 2 179 ? 213.380 248.061 366.878 1.00 2.19  ? 179 VAL B CB  1 
ATOM   2653 C CG1 . VAL B 2 179 ? 212.577 248.197 368.160 1.00 6.07  ? 179 VAL B CG1 1 
ATOM   2654 C CG2 . VAL B 2 179 ? 214.587 248.990 366.885 1.00 5.29  ? 179 VAL B CG2 1 
ATOM   2655 N N   . GLN B 2 180 ? 212.449 244.847 367.614 1.00 8.70  ? 180 GLN B N   1 
ATOM   2656 C CA  . GLN B 2 180 ? 211.429 243.808 367.635 1.00 8.13  ? 180 GLN B CA  1 
ATOM   2657 C C   . GLN B 2 180 ? 210.501 244.061 368.811 1.00 5.06  ? 180 GLN B C   1 
ATOM   2658 O O   . GLN B 2 180 ? 210.949 244.108 369.961 1.00 13.51 ? 180 GLN B O   1 
ATOM   2659 C CB  . GLN B 2 180 ? 212.072 242.426 367.747 1.00 8.20  ? 180 GLN B CB  1 
ATOM   2660 C CG  . GLN B 2 180 ? 212.952 242.062 366.571 1.00 10.22 ? 180 GLN B CG  1 
ATOM   2661 C CD  . GLN B 2 180 ? 214.149 241.232 366.982 1.00 7.92  ? 180 GLN B CD  1 
ATOM   2662 O OE1 . GLN B 2 180 ? 214.172 240.020 366.792 1.00 14.96 ? 180 GLN B OE1 1 
ATOM   2663 N NE2 . GLN B 2 180 ? 215.151 241.885 367.552 1.00 10.42 ? 180 GLN B NE2 1 
ATOM   2664 N N   . CYS B 2 181 ? 209.210 244.227 368.519 1.00 8.70  ? 181 CYS B N   1 
ATOM   2665 C CA  . CYS B 2 181 ? 208.223 244.498 369.561 1.00 9.87  ? 181 CYS B CA  1 
ATOM   2666 C C   . CYS B 2 181 ? 206.867 244.018 369.045 1.00 11.12 ? 181 CYS B C   1 
ATOM   2667 O O   . CYS B 2 181 ? 206.225 244.712 368.252 1.00 20.18 ? 181 CYS B O   1 
ATOM   2668 C CB  . CYS B 2 181 ? 208.193 245.975 369.918 1.00 8.20  ? 181 CYS B CB  1 
ATOM   2669 S SG  . CYS B 2 181 ? 206.862 246.438 371.044 1.00 16.04 ? 181 CYS B SG  1 
ATOM   2670 N N   . ASN B 2 182 ? 206.444 242.849 369.508 1.00 13.94 ? 182 ASN B N   1 
ATOM   2671 C CA  . ASN B 2 182 ? 205.169 242.268 369.120 1.00 10.17 ? 182 ASN B CA  1 
ATOM   2672 C C   . ASN B 2 182 ? 204.174 242.370 370.267 1.00 7.25  ? 182 ASN B C   1 
ATOM   2673 O O   . ASN B 2 182 ? 204.544 242.359 371.443 1.00 12.93 ? 182 ASN B O   1 
ATOM   2674 C CB  . ASN B 2 182 ? 205.327 240.803 368.701 1.00 12.57 ? 182 ASN B CB  1 
ATOM   2675 C CG  . ASN B 2 182 ? 206.109 239.992 369.706 1.00 6.63  ? 182 ASN B CG  1 
ATOM   2676 O OD1 . ASN B 2 182 ? 207.307 239.779 369.544 1.00 15.74 ? 182 ASN B OD1 1 
ATOM   2677 N ND2 . ASN B 2 182 ? 205.439 239.546 370.760 1.00 9.33  ? 182 ASN B ND2 1 
ATOM   2678 N N   . ALA B 2 183 ? 202.905 242.491 369.900 1.00 7.87  ? 183 ALA B N   1 
ATOM   2679 C CA  . ALA B 2 183 ? 201.811 242.558 370.852 1.00 11.15 ? 183 ALA B CA  1 
ATOM   2680 C C   . ALA B 2 183 ? 200.580 241.972 370.174 1.00 7.44  ? 183 ALA B C   1 
ATOM   2681 O O   . ALA B 2 183 ? 200.635 241.530 369.025 1.00 22.26 ? 183 ALA B O   1 
ATOM   2682 C CB  . ALA B 2 183 ? 201.580 243.997 371.325 1.00 7.93  ? 183 ALA B CB  1 
ATOM   2683 N N   . SER B 2 184 ? 199.462 241.975 370.887 1.00 6.51  ? 184 SER B N   1 
ATOM   2684 C CA  . SER B 2 184 ? 198.242 241.406 370.343 1.00 8.91  ? 184 SER B CA  1 
ATOM   2685 C C   . SER B 2 184 ? 197.510 242.429 369.476 1.00 6.06  ? 184 SER B C   1 
ATOM   2686 O O   . SER B 2 184 ? 197.821 243.622 369.469 1.00 14.40 ? 184 SER B O   1 
ATOM   2687 C CB  . SER B 2 184 ? 197.332 240.917 371.468 1.00 7.97  ? 184 SER B CB  1 
ATOM   2688 O OG  . SER B 2 184 ? 196.717 242.004 372.136 1.00 11.49 ? 184 SER B OG  1 
ATOM   2689 N N   . LYS B 2 185 ? 196.512 241.942 368.737 1.00 8.73  ? 185 LYS B N   1 
ATOM   2690 C CA  . LYS B 2 185 ? 195.630 242.839 368.003 1.00 8.67  ? 185 LYS B CA  1 
ATOM   2691 C C   . LYS B 2 185 ? 194.812 243.716 368.939 1.00 6.80  ? 185 LYS B C   1 
ATOM   2692 O O   . LYS B 2 185 ? 194.220 244.702 368.491 1.00 12.83 ? 185 LYS B O   1 
ATOM   2693 C CB  . LYS B 2 185 ? 194.696 242.035 367.097 1.00 12.52 ? 185 LYS B CB  1 
ATOM   2694 C CG  . LYS B 2 185 ? 195.413 241.226 366.033 1.00 8.61  ? 185 LYS B CG  1 
ATOM   2695 C CD  . LYS B 2 185 ? 194.427 240.491 365.145 1.00 10.36 ? 185 LYS B CD  1 
ATOM   2696 C CE  . LYS B 2 185 ? 195.131 239.535 364.199 1.00 15.21 ? 185 LYS B CE  1 
ATOM   2697 N NZ  . LYS B 2 185 ? 196.142 240.218 363.352 1.00 21.44 ? 185 LYS B NZ  1 
ATOM   2698 N N   . PHE B 2 186 ? 194.759 243.373 370.223 1.00 4.09  ? 186 PHE B N   1 
ATOM   2699 C CA  . PHE B 2 186 ? 194.037 244.150 371.218 1.00 9.42  ? 186 PHE B CA  1 
ATOM   2700 C C   . PHE B 2 186 ? 194.938 245.105 371.991 1.00 6.38  ? 186 PHE B C   1 
ATOM   2701 O O   . PHE B 2 186 ? 194.447 245.827 372.860 1.00 9.56  ? 186 PHE B O   1 
ATOM   2702 C CB  . PHE B 2 186 ? 193.313 243.206 372.183 1.00 9.19  ? 186 PHE B CB  1 
ATOM   2703 C CG  . PHE B 2 186 ? 192.235 242.390 371.526 1.00 7.86  ? 186 PHE B CG  1 
ATOM   2704 C CD1 . PHE B 2 186 ? 192.553 241.260 370.791 1.00 8.67  ? 186 PHE B CD1 1 
ATOM   2705 C CD2 . PHE B 2 186 ? 190.904 242.761 371.631 1.00 8.09  ? 186 PHE B CD2 1 
ATOM   2706 C CE1 . PHE B 2 186 ? 191.562 240.511 370.179 1.00 11.39 ? 186 PHE B CE1 1 
ATOM   2707 C CE2 . PHE B 2 186 ? 189.911 242.016 371.023 1.00 8.08  ? 186 PHE B CE2 1 
ATOM   2708 C CZ  . PHE B 2 186 ? 190.240 240.891 370.295 1.00 11.35 ? 186 PHE B CZ  1 
ATOM   2709 N N   . HIS B 2 187 ? 196.234 245.118 371.705 1.00 14.62 ? 187 HIS B N   1 
ATOM   2710 C CA  . HIS B 2 187 ? 197.130 246.137 372.227 1.00 10.92 ? 187 HIS B CA  1 
ATOM   2711 C C   . HIS B 2 187 ? 197.128 247.349 371.303 1.00 3.40  ? 187 HIS B C   1 
ATOM   2712 O O   . HIS B 2 187 ? 196.724 247.275 370.142 1.00 18.31 ? 187 HIS B O   1 
ATOM   2713 C CB  . HIS B 2 187 ? 198.555 245.598 372.367 1.00 6.55  ? 187 HIS B CB  1 
ATOM   2714 C CG  . HIS B 2 187 ? 198.751 244.686 373.537 1.00 11.74 ? 187 HIS B CG  1 
ATOM   2715 N ND1 . HIS B 2 187 ? 198.370 243.362 373.523 1.00 7.13  ? 187 HIS B ND1 1 
ATOM   2716 C CD2 . HIS B 2 187 ? 199.303 244.905 374.753 1.00 9.95  ? 187 HIS B CD2 1 
ATOM   2717 C CE1 . HIS B 2 187 ? 198.671 242.808 374.682 1.00 9.58  ? 187 HIS B CE1 1 
ATOM   2718 N NE2 . HIS B 2 187 ? 199.239 243.722 375.447 1.00 11.17 ? 187 HIS B NE2 1 
ATOM   2719 N N   . GLN B 2 188 ? 197.576 248.479 371.840 1.00 7.58  ? 188 GLN B N   1 
ATOM   2720 C CA  . GLN B 2 188 ? 197.770 249.683 371.046 1.00 7.80  ? 188 GLN B CA  1 
ATOM   2721 C C   . GLN B 2 188 ? 198.986 250.431 371.571 1.00 8.37  ? 188 GLN B C   1 
ATOM   2722 O O   . GLN B 2 188 ? 199.369 250.302 372.735 1.00 13.27 ? 188 GLN B O   1 
ATOM   2723 C CB  . GLN B 2 188 ? 196.535 250.594 371.069 1.00 8.55  ? 188 GLN B CB  1 
ATOM   2724 C CG  . GLN B 2 188 ? 196.294 251.291 372.395 1.00 8.45  ? 188 GLN B CG  1 
ATOM   2725 C CD  . GLN B 2 188 ? 194.988 252.055 372.419 1.00 11.58 ? 188 GLN B CD  1 
ATOM   2726 O OE1 . GLN B 2 188 ? 194.040 251.700 371.724 1.00 14.72 ? 188 GLN B OE1 1 
ATOM   2727 N NE2 . GLN B 2 188 ? 194.933 253.112 373.217 1.00 10.11 ? 188 GLN B NE2 1 
ATOM   2728 N N   . GLY B 2 189 ? 199.578 251.218 370.697 1.00 6.97  ? 189 GLY B N   1 
ATOM   2729 C CA  . GLY B 2 189 ? 200.772 251.976 371.003 1.00 4.92  ? 189 GLY B CA  1 
ATOM   2730 C C   . GLY B 2 189 ? 201.643 252.087 369.773 1.00 5.06  ? 189 GLY B C   1 
ATOM   2731 O O   . GLY B 2 189 ? 201.541 251.313 368.825 1.00 8.48  ? 189 GLY B O   1 
ATOM   2732 N N   . ALA B 2 190 ? 202.520 253.083 369.785 1.00 6.52  ? 190 ALA B N   1 
ATOM   2733 C CA  . ALA B 2 190 ? 203.415 253.313 368.664 1.00 7.44  ? 190 ALA B CA  1 
ATOM   2734 C C   . ALA B 2 190 ? 204.774 253.753 369.181 1.00 5.71  ? 190 ALA B C   1 
ATOM   2735 O O   . ALA B 2 190 ? 204.866 254.526 370.135 1.00 13.74 ? 190 ALA B O   1 
ATOM   2736 C CB  . ALA B 2 190 ? 202.848 254.363 367.699 1.00 5.54  ? 190 ALA B CB  1 
ATOM   2737 N N   . LEU B 2 191 ? 205.824 253.247 368.547 1.00 10.23 ? 191 LEU B N   1 
ATOM   2738 C CA  . LEU B 2 191 ? 207.193 253.635 368.843 1.00 2.14  ? 191 LEU B CA  1 
ATOM   2739 C C   . LEU B 2 191 ? 207.798 254.327 367.632 1.00 7.24  ? 191 LEU B C   1 
ATOM   2740 O O   . LEU B 2 191 ? 207.625 253.876 366.498 1.00 7.13  ? 191 LEU B O   1 
ATOM   2741 C CB  . LEU B 2 191 ? 208.047 252.420 369.219 1.00 3.90  ? 191 LEU B CB  1 
ATOM   2742 C CG  . LEU B 2 191 ? 207.571 251.571 370.398 1.00 9.10  ? 191 LEU B CG  1 
ATOM   2743 C CD1 . LEU B 2 191 ? 208.330 250.258 370.433 1.00 7.07  ? 191 LEU B CD1 1 
ATOM   2744 C CD2 . LEU B 2 191 ? 207.730 252.321 371.711 1.00 3.68  ? 191 LEU B CD2 1 
ATOM   2745 N N   . GLY B 2 192 ? 208.490 255.438 367.876 1.00 3.02  ? 192 GLY B N   1 
ATOM   2746 C CA  . GLY B 2 192 ? 209.348 256.041 366.889 1.00 3.39  ? 192 GLY B CA  1 
ATOM   2747 C C   . GLY B 2 192 ? 210.773 255.591 367.137 1.00 3.85  ? 192 GLY B C   1 
ATOM   2748 O O   . GLY B 2 192 ? 211.321 255.810 368.218 1.00 5.64  ? 192 GLY B O   1 
ATOM   2749 N N   . VAL B 2 193 ? 211.356 254.930 366.143 1.00 8.02  ? 193 VAL B N   1 
ATOM   2750 C CA  . VAL B 2 193 ? 212.737 254.473 366.192 1.00 6.50  ? 193 VAL B CA  1 
ATOM   2751 C C   . VAL B 2 193 ? 213.534 255.387 365.277 1.00 0.01  ? 193 VAL B C   1 
ATOM   2752 O O   . VAL B 2 193 ? 213.310 255.403 364.062 1.00 9.68  ? 193 VAL B O   1 
ATOM   2753 C CB  . VAL B 2 193 ? 212.864 253.004 365.760 1.00 5.40  ? 193 VAL B CB  1 
ATOM   2754 C CG1 . VAL B 2 193 ? 214.308 252.533 365.873 1.00 8.37  ? 193 VAL B CG1 1 
ATOM   2755 C CG2 . VAL B 2 193 ? 211.938 252.121 366.588 1.00 8.40  ? 193 VAL B CG2 1 
ATOM   2756 N N   . PHE B 2 194 ? 214.453 256.150 365.857 1.00 0.76  ? 194 PHE B N   1 
ATOM   2757 C CA  . PHE B 2 194 ? 215.236 257.144 365.139 1.00 5.54  ? 194 PHE B CA  1 
ATOM   2758 C C   . PHE B 2 194 ? 216.710 256.770 365.211 1.00 2.56  ? 194 PHE B C   1 
ATOM   2759 O O   . PHE B 2 194 ? 217.227 256.470 366.292 1.00 6.36  ? 194 PHE B O   1 
ATOM   2760 C CB  . PHE B 2 194 ? 215.018 258.542 365.728 1.00 1.30  ? 194 PHE B CB  1 
ATOM   2761 C CG  . PHE B 2 194 ? 213.572 258.945 365.833 1.00 0.49  ? 194 PHE B CG  1 
ATOM   2762 C CD1 . PHE B 2 194 ? 212.819 258.590 366.940 1.00 1.26  ? 194 PHE B CD1 1 
ATOM   2763 C CD2 . PHE B 2 194 ? 212.968 259.681 364.827 1.00 4.76  ? 194 PHE B CD2 1 
ATOM   2764 C CE1 . PHE B 2 194 ? 211.492 258.960 367.041 1.00 6.60  ? 194 PHE B CE1 1 
ATOM   2765 C CE2 . PHE B 2 194 ? 211.642 260.054 364.921 1.00 0.40  ? 194 PHE B CE2 1 
ATOM   2766 C CZ  . PHE B 2 194 ? 210.901 259.693 366.030 1.00 3.39  ? 194 PHE B CZ  1 
ATOM   2767 N N   . ALA B 2 195 ? 217.376 256.778 364.060 1.00 3.40  ? 195 ALA B N   1 
ATOM   2768 C CA  . ALA B 2 195 ? 218.826 256.681 363.985 1.00 3.16  ? 195 ALA B CA  1 
ATOM   2769 C C   . ALA B 2 195 ? 219.376 258.081 363.739 1.00 0.94  ? 195 ALA B C   1 
ATOM   2770 O O   . ALA B 2 195 ? 219.076 258.700 362.714 1.00 10.92 ? 195 ALA B O   1 
ATOM   2771 C CB  . ALA B 2 195 ? 219.258 255.719 362.881 1.00 3.62  ? 195 ALA B CB  1 
ATOM   2772 N N   . VAL B 2 196 ? 220.174 258.570 364.678 1.00 6.75  ? 196 VAL B N   1 
ATOM   2773 C CA  . VAL B 2 196 ? 220.625 259.952 364.717 1.00 7.87  ? 196 VAL B CA  1 
ATOM   2774 C C   . VAL B 2 196 ? 222.142 259.971 364.560 1.00 5.42  ? 196 VAL B C   1 
ATOM   2775 O O   . VAL B 2 196 ? 222.854 259.448 365.418 1.00 4.54  ? 196 VAL B O   1 
ATOM   2776 C CB  . VAL B 2 196 ? 220.214 260.643 366.027 1.00 8.17  ? 196 VAL B CB  1 
ATOM   2777 C CG1 . VAL B 2 196 ? 220.695 262.088 366.041 1.00 2.31  ? 196 VAL B CG1 1 
ATOM   2778 C CG2 . VAL B 2 196 ? 218.709 260.553 366.218 1.00 8.12  ? 196 VAL B CG2 1 
ATOM   2779 N N   . PRO B 2 197 ? 222.690 260.563 363.502 1.00 5.28  ? 197 PRO B N   1 
ATOM   2780 C CA  . PRO B 2 197 ? 224.148 260.726 363.445 1.00 4.26  ? 197 PRO B CA  1 
ATOM   2781 C C   . PRO B 2 197 ? 224.601 261.769 364.457 1.00 0.01  ? 197 PRO B C   1 
ATOM   2782 O O   . PRO B 2 197 ? 224.002 262.839 364.573 1.00 8.85  ? 197 PRO B O   1 
ATOM   2783 C CB  . PRO B 2 197 ? 224.400 261.178 362.003 1.00 6.35  ? 197 PRO B CB  1 
ATOM   2784 C CG  . PRO B 2 197 ? 223.141 261.831 361.591 1.00 12.90 ? 197 PRO B CG  1 
ATOM   2785 C CD  . PRO B 2 197 ? 222.026 261.134 362.318 1.00 1.58  ? 197 PRO B CD  1 
ATOM   2786 N N   . GLU B 2 198 ? 225.658 261.446 365.200 1.00 6.11  ? 198 GLU B N   1 
ATOM   2787 C CA  . GLU B 2 198 ? 226.212 262.345 366.211 1.00 2.39  ? 198 GLU B CA  1 
ATOM   2788 C C   . GLU B 2 198 ? 225.144 262.724 367.241 1.00 3.93  ? 198 GLU B C   1 
ATOM   2789 O O   . GLU B 2 198 ? 224.868 263.899 367.485 1.00 15.78 ? 198 GLU B O   1 
ATOM   2790 C CB  . GLU B 2 198 ? 226.804 263.601 365.561 1.00 0.20  ? 198 GLU B CB  1 
ATOM   2791 C CG  . GLU B 2 198 ? 227.731 263.342 364.386 1.00 0.01  ? 198 GLU B CG  1 
ATOM   2792 C CD  . GLU B 2 198 ? 229.067 262.772 364.806 1.00 11.86 ? 198 GLU B CD  1 
ATOM   2793 O OE1 . GLU B 2 198 ? 229.257 262.521 366.012 1.00 15.16 ? 198 GLU B OE1 1 
ATOM   2794 O OE2 . GLU B 2 198 ? 229.929 262.577 363.927 1.00 18.12 ? 198 GLU B OE2 1 
ATOM   2795 N N   . MET B 2 199 ? 224.542 261.700 367.845 1.00 6.02  ? 199 MET B N   1 
ATOM   2796 C CA  . MET B 2 199 ? 223.440 261.906 368.786 1.00 6.21  ? 199 MET B CA  1 
ATOM   2797 C C   . MET B 2 199 ? 224.007 262.381 370.122 1.00 6.79  ? 199 MET B C   1 
ATOM   2798 O O   . MET B 2 199 ? 224.133 261.630 371.091 1.00 13.60 ? 199 MET B O   1 
ATOM   2799 C CB  . MET B 2 199 ? 222.619 260.634 368.949 1.00 9.53  ? 199 MET B CB  1 
ATOM   2800 C CG  . MET B 2 199 ? 221.259 260.875 369.593 1.00 11.07 ? 199 MET B CG  1 
ATOM   2801 S SD  . MET B 2 199 ? 220.180 259.429 369.615 1.00 22.44 ? 199 MET B SD  1 
ATOM   2802 C CE  . MET B 2 199 ? 220.833 258.532 371.016 1.00 11.92 ? 199 MET B CE  1 
ATOM   2803 N N   . CYS B 2 200 ? 224.341 263.666 370.170 1.00 6.12  ? 200 CYS B N   1 
ATOM   2804 C CA  . CYS B 2 200 ? 224.791 264.275 371.412 1.00 8.35  ? 200 CYS B CA  1 
ATOM   2805 C C   . CYS B 2 200 ? 223.604 264.499 372.341 1.00 5.48  ? 200 CYS B C   1 
ATOM   2806 O O   . CYS B 2 200 ? 222.529 264.917 371.907 1.00 20.25 ? 200 CYS B O   1 
ATOM   2807 C CB  . CYS B 2 200 ? 225.501 265.600 371.129 1.00 2.75  ? 200 CYS B CB  1 
ATOM   2808 S SG  . CYS B 2 200 ? 226.915 265.470 370.008 1.00 21.56 ? 200 CYS B SG  1 
ATOM   2809 N N   . LEU B 2 201 ? 223.801 264.214 373.625 1.00 5.92  ? 201 LEU B N   1 
ATOM   2810 C CA  . LEU B 2 201 ? 222.744 264.322 374.618 1.00 7.32  ? 201 LEU B CA  1 
ATOM   2811 C C   . LEU B 2 201 ? 223.106 265.367 375.665 1.00 9.70  ? 201 LEU B C   1 
ATOM   2812 O O   . LEU B 2 201 ? 224.279 265.568 375.990 1.00 12.58 ? 201 LEU B O   1 
ATOM   2813 C CB  . LEU B 2 201 ? 222.476 262.971 375.298 1.00 6.55  ? 201 LEU B CB  1 
ATOM   2814 C CG  . LEU B 2 201 ? 222.007 261.845 374.371 1.00 7.76  ? 201 LEU B CG  1 
ATOM   2815 C CD1 . LEU B 2 201 ? 221.725 260.572 375.160 1.00 10.35 ? 201 LEU B CD1 1 
ATOM   2816 C CD2 . LEU B 2 201 ? 220.780 262.270 373.576 1.00 7.42  ? 201 LEU B CD2 1 
ATOM   2817 N N   . ALA B 2 202 ? 222.080 266.039 376.177 1.00 9.28  ? 202 ALA B N   1 
ATOM   2818 C CA  . ALA B 2 202 ? 222.278 267.083 377.170 1.00 12.38 ? 202 ALA B CA  1 
ATOM   2819 C C   . ALA B 2 202 ? 222.700 266.489 378.508 1.00 9.20  ? 202 ALA B C   1 
ATOM   2820 O O   . ALA B 2 202 ? 222.322 265.371 378.865 1.00 15.73 ? 202 ALA B O   1 
ATOM   2821 C CB  . ALA B 2 202 ? 220.998 267.900 377.347 1.00 5.36  ? 202 ALA B CB  1 
ATOM   2822 N N   . GLY B 2 203 ? 223.485 267.260 379.255 1.00 5.76  ? 203 GLY B N   1 
ATOM   2823 C CA  . GLY B 2 203 ? 223.959 266.846 380.557 1.00 14.47 ? 203 GLY B CA  1 
ATOM   2824 C C   . GLY B 2 203 ? 222.928 267.075 381.646 1.00 11.85 ? 203 GLY B C   1 
ATOM   2825 O O   . GLY B 2 203 ? 221.759 267.371 381.397 1.00 16.69 ? 203 GLY B O   1 
ATOM   2826 N N   . ASP B 2 204 ? 223.388 266.930 382.890 1.00 18.49 ? 204 ASP B N   1 
ATOM   2827 C CA  . ASP B 2 204 ? 222.533 267.049 384.066 1.00 15.71 ? 204 ASP B CA  1 
ATOM   2828 C C   . ASP B 2 204 ? 223.035 268.106 385.044 1.00 20.56 ? 204 ASP B C   1 
ATOM   2829 O O   . ASP B 2 204 ? 222.587 268.137 386.193 1.00 26.78 ? 204 ASP B O   1 
ATOM   2830 C CB  . ASP B 2 204 ? 222.419 265.697 384.774 1.00 18.33 ? 204 ASP B CB  1 
ATOM   2831 C CG  . ASP B 2 204 ? 223.751 265.214 385.338 1.00 19.93 ? 204 ASP B CG  1 
ATOM   2832 O OD1 . ASP B 2 204 ? 224.782 265.884 385.120 1.00 19.45 ? 204 ASP B OD1 1 
ATOM   2833 O OD2 . ASP B 2 204 ? 223.767 264.159 386.001 1.00 22.30 ? 204 ASP B OD2 1 
ATOM   2834 N N   . SER B 2 205 ? 223.952 268.973 384.620 1.00 18.39 ? 205 SER B N   1 
ATOM   2835 C CA  . SER B 2 205 ? 224.619 269.888 385.534 1.00 20.67 ? 205 SER B CA  1 
ATOM   2836 C C   . SER B 2 205 ? 224.784 271.253 384.884 1.00 18.82 ? 205 SER B C   1 
ATOM   2837 O O   . SER B 2 205 ? 224.713 271.399 383.661 1.00 24.37 ? 205 SER B O   1 
ATOM   2838 C CB  . SER B 2 205 ? 225.991 269.351 385.959 1.00 22.62 ? 205 SER B CB  1 
ATOM   2839 O OG  . SER B 2 205 ? 226.820 269.138 384.832 1.00 22.22 ? 205 SER B OG  1 
ATOM   2840 N N   . THR B 2 206 ? 225.008 272.261 385.729 1.00 20.08 ? 206 THR B N   1 
ATOM   2841 C CA  . THR B 2 206 ? 225.299 273.597 385.229 1.00 21.99 ? 206 THR B CA  1 
ATOM   2842 C C   . THR B 2 206 ? 226.660 273.667 384.550 1.00 17.06 ? 206 THR B C   1 
ATOM   2843 O O   . THR B 2 206 ? 226.910 274.604 383.786 1.00 20.90 ? 206 THR B O   1 
ATOM   2844 C CB  . THR B 2 206 ? 225.235 274.618 386.367 1.00 22.22 ? 206 THR B CB  1 
ATOM   2845 O OG1 . THR B 2 206 ? 226.265 274.344 387.324 1.00 25.83 ? 206 THR B OG1 1 
ATOM   2846 C CG2 . THR B 2 206 ? 223.880 274.564 387.055 1.00 21.01 ? 206 THR B CG2 1 
ATOM   2847 N N   . THR B 2 207 ? 227.541 272.706 384.813 1.00 20.65 ? 207 THR B N   1 
ATOM   2848 C CA  . THR B 2 207 ? 228.817 272.636 384.117 1.00 16.59 ? 207 THR B CA  1 
ATOM   2849 C C   . THR B 2 207 ? 228.594 272.088 382.713 1.00 13.92 ? 207 THR B C   1 
ATOM   2850 O O   . THR B 2 207 ? 227.986 271.029 382.541 1.00 18.60 ? 207 THR B O   1 
ATOM   2851 C CB  . THR B 2 207 ? 229.799 271.752 384.887 1.00 17.46 ? 207 THR B CB  1 
ATOM   2852 O OG1 . THR B 2 207 ? 229.936 272.240 386.227 1.00 22.81 ? 207 THR B OG1 1 
ATOM   2853 C CG2 . THR B 2 207 ? 231.163 271.746 384.214 1.00 16.95 ? 207 THR B CG2 1 
ATOM   2854 N N   . HIS B 2 208 ? 229.079 272.815 381.712 1.00 18.21 ? 208 HIS B N   1 
ATOM   2855 C CA  . HIS B 2 208 ? 228.838 272.430 380.329 1.00 15.04 ? 208 HIS B CA  1 
ATOM   2856 C C   . HIS B 2 208 ? 229.641 271.189 379.960 1.00 16.99 ? 208 HIS B C   1 
ATOM   2857 O O   . HIS B 2 208 ? 230.789 271.024 380.378 1.00 16.92 ? 208 HIS B O   1 
ATOM   2858 C CB  . HIS B 2 208 ? 229.201 273.577 379.388 1.00 15.95 ? 208 HIS B CB  1 
ATOM   2859 C CG  . HIS B 2 208 ? 228.427 274.833 379.640 1.00 15.42 ? 208 HIS B CG  1 
ATOM   2860 N ND1 . HIS B 2 208 ? 228.947 276.086 379.400 1.00 16.24 ? 208 HIS B ND1 1 
ATOM   2861 C CD2 . HIS B 2 208 ? 227.172 275.030 380.107 1.00 15.87 ? 208 HIS B CD2 1 
ATOM   2862 C CE1 . HIS B 2 208 ? 228.047 277.001 379.712 1.00 17.28 ? 208 HIS B CE1 1 
ATOM   2863 N NE2 . HIS B 2 208 ? 226.959 276.386 380.140 1.00 21.64 ? 208 HIS B NE2 1 
ATOM   2864 N N   . MET B 2 209 ? 229.023 270.314 379.166 1.00 16.41 ? 209 MET B N   1 
ATOM   2865 C CA  . MET B 2 209 ? 229.721 269.188 378.545 1.00 16.01 ? 209 MET B CA  1 
ATOM   2866 C C   . MET B 2 209 ? 230.427 268.330 379.593 1.00 9.89  ? 209 MET B C   1 
ATOM   2867 O O   . MET B 2 209 ? 231.553 267.875 379.393 1.00 18.06 ? 209 MET B O   1 
ATOM   2868 C CB  . MET B 2 209 ? 230.711 269.692 377.493 1.00 15.45 ? 209 MET B CB  1 
ATOM   2869 C CG  . MET B 2 209 ? 230.063 270.538 376.399 1.00 12.55 ? 209 MET B CG  1 
ATOM   2870 S SD  . MET B 2 209 ? 231.233 271.469 375.391 1.00 35.32 ? 209 MET B SD  1 
ATOM   2871 C CE  . MET B 2 209 ? 232.034 270.163 374.467 1.00 18.03 ? 209 MET B CE  1 
ATOM   2872 N N   . PHE B 2 210 ? 229.753 268.104 380.717 1.00 15.81 ? 210 PHE B N   1 
ATOM   2873 C CA  . PHE B 2 210 ? 230.360 267.507 381.896 1.00 18.61 ? 210 PHE B CA  1 
ATOM   2874 C C   . PHE B 2 210 ? 230.041 266.026 382.060 1.00 11.72 ? 210 PHE B C   1 
ATOM   2875 O O   . PHE B 2 210 ? 230.483 265.421 383.040 1.00 18.04 ? 210 PHE B O   1 
ATOM   2876 C CB  . PHE B 2 210 ? 229.908 268.277 383.145 1.00 15.53 ? 210 PHE B CB  1 
ATOM   2877 C CG  . PHE B 2 210 ? 230.825 268.133 384.334 1.00 17.43 ? 210 PHE B CG  1 
ATOM   2878 C CD1 . PHE B 2 210 ? 232.202 268.117 384.182 1.00 16.64 ? 210 PHE B CD1 1 
ATOM   2879 C CD2 . PHE B 2 210 ? 230.301 268.055 385.612 1.00 18.13 ? 210 PHE B CD2 1 
ATOM   2880 C CE1 . PHE B 2 210 ? 233.032 268.002 385.278 1.00 16.94 ? 210 PHE B CE1 1 
ATOM   2881 C CE2 . PHE B 2 210 ? 231.128 267.941 386.711 1.00 19.08 ? 210 PHE B CE2 1 
ATOM   2882 C CZ  . PHE B 2 210 ? 232.493 267.914 386.543 1.00 16.41 ? 210 PHE B CZ  1 
ATOM   2883 N N   . THR B 2 211 ? 229.294 265.427 381.136 1.00 9.86  ? 211 THR B N   1 
ATOM   2884 C CA  . THR B 2 211 ? 228.967 264.009 381.237 1.00 15.31 ? 211 THR B CA  1 
ATOM   2885 C C   . THR B 2 211 ? 230.228 263.177 381.031 1.00 12.21 ? 211 THR B C   1 
ATOM   2886 O O   . THR B 2 211 ? 230.901 263.302 380.004 1.00 14.63 ? 211 THR B O   1 
ATOM   2887 C CB  . THR B 2 211 ? 227.898 263.639 380.211 1.00 13.76 ? 211 THR B CB  1 
ATOM   2888 O OG1 . THR B 2 211 ? 226.704 264.386 380.472 1.00 23.32 ? 211 THR B OG1 1 
ATOM   2889 C CG2 . THR B 2 211 ? 227.582 262.148 380.270 1.00 12.90 ? 211 THR B CG2 1 
ATOM   2890 N N   . LYS B 2 212 ? 230.549 262.327 382.002 1.00 10.42 ? 212 LYS B N   1 
ATOM   2891 C CA  . LYS B 2 212 ? 231.795 261.584 381.943 1.00 19.20 ? 212 LYS B CA  1 
ATOM   2892 C C   . LYS B 2 212 ? 231.678 260.398 380.989 1.00 9.99  ? 212 LYS B C   1 
ATOM   2893 O O   . LYS B 2 212 ? 230.586 259.963 380.616 1.00 15.07 ? 212 LYS B O   1 
ATOM   2894 C CB  . LYS B 2 212 ? 232.216 261.112 383.336 1.00 14.68 ? 212 LYS B CB  1 
ATOM   2895 C CG  . LYS B 2 212 ? 231.307 260.085 383.976 1.00 19.80 ? 212 LYS B CG  1 
ATOM   2896 C CD  . LYS B 2 212 ? 231.850 259.679 385.335 1.00 22.01 ? 212 LYS B CD  1 
ATOM   2897 C CE  . LYS B 2 212 ? 230.974 258.643 386.010 1.00 23.82 ? 212 LYS B CE  1 
ATOM   2898 N NZ  . LYS B 2 212 ? 231.449 258.336 387.387 1.00 27.01 ? 212 LYS B NZ  1 
ATOM   2899 N N   . TYR B 2 213 ? 232.842 259.869 380.607 1.00 19.10 ? 213 TYR B N   1 
ATOM   2900 C CA  . TYR B 2 213 ? 232.898 258.842 379.574 1.00 15.95 ? 213 TYR B CA  1 
ATOM   2901 C C   . TYR B 2 213 ? 232.083 257.614 379.960 1.00 7.68  ? 213 TYR B C   1 
ATOM   2902 O O   . TYR B 2 213 ? 231.387 257.036 379.119 1.00 11.14 ? 213 TYR B O   1 
ATOM   2903 C CB  . TYR B 2 213 ? 234.354 258.459 379.311 1.00 16.26 ? 213 TYR B CB  1 
ATOM   2904 C CG  . TYR B 2 213 ? 234.536 257.452 378.204 1.00 12.12 ? 213 TYR B CG  1 
ATOM   2905 C CD1 . TYR B 2 213 ? 234.489 256.089 378.463 1.00 12.68 ? 213 TYR B CD1 1 
ATOM   2906 C CD2 . TYR B 2 213 ? 234.765 257.863 376.900 1.00 14.70 ? 213 TYR B CD2 1 
ATOM   2907 C CE1 . TYR B 2 213 ? 234.657 255.165 377.452 1.00 14.14 ? 213 TYR B CE1 1 
ATOM   2908 C CE2 . TYR B 2 213 ? 234.935 256.949 375.884 1.00 14.47 ? 213 TYR B CE2 1 
ATOM   2909 C CZ  . TYR B 2 213 ? 234.882 255.600 376.166 1.00 16.71 ? 213 TYR B CZ  1 
ATOM   2910 O OH  . TYR B 2 213 ? 235.050 254.686 375.156 1.00 23.94 ? 213 TYR B OH  1 
ATOM   2911 N N   . GLU B 2 214 ? 232.153 257.203 381.228 1.00 15.50 ? 214 GLU B N   1 
ATOM   2912 C CA  . GLU B 2 214 ? 231.462 255.988 381.649 1.00 16.24 ? 214 GLU B CA  1 
ATOM   2913 C C   . GLU B 2 214 ? 229.957 256.105 381.442 1.00 17.47 ? 214 GLU B C   1 
ATOM   2914 O O   . GLU B 2 214 ? 229.312 255.159 380.974 1.00 23.97 ? 214 GLU B O   1 
ATOM   2915 C CB  . GLU B 2 214 ? 231.769 255.685 383.117 1.00 17.78 ? 214 GLU B CB  1 
ATOM   2916 C CG  . GLU B 2 214 ? 233.202 255.265 383.389 1.00 21.20 ? 214 GLU B CG  1 
ATOM   2917 C CD  . GLU B 2 214 ? 234.185 256.417 383.313 1.00 23.32 ? 214 GLU B CD  1 
ATOM   2918 O OE1 . GLU B 2 214 ? 233.751 257.569 383.108 1.00 24.72 ? 214 GLU B OE1 1 
ATOM   2919 O OE2 . GLU B 2 214 ? 235.396 256.168 383.456 1.00 26.59 ? 214 GLU B OE2 1 
ATOM   2920 N N   . ASN B 2 215 ? 229.379 257.255 381.788 1.00 20.99 ? 215 ASN B N   1 
ATOM   2921 C CA  . ASN B 2 215 ? 227.944 257.446 381.626 1.00 12.89 ? 215 ASN B CA  1 
ATOM   2922 C C   . ASN B 2 215 ? 227.558 257.702 380.175 1.00 8.89  ? 215 ASN B C   1 
ATOM   2923 O O   . ASN B 2 215 ? 226.470 257.300 379.751 1.00 18.61 ? 215 ASN B O   1 
ATOM   2924 C CB  . ASN B 2 215 ? 227.472 258.598 382.513 1.00 16.28 ? 215 ASN B CB  1 
ATOM   2925 C CG  . ASN B 2 215 ? 227.585 258.273 383.986 1.00 16.93 ? 215 ASN B CG  1 
ATOM   2926 O OD1 . ASN B 2 215 ? 227.424 257.123 384.387 1.00 23.45 ? 215 ASN B OD1 1 
ATOM   2927 N ND2 . ASN B 2 215 ? 227.871 259.280 384.799 1.00 17.94 ? 215 ASN B ND2 1 
ATOM   2928 N N   . ALA B 2 216 ? 228.425 258.358 379.403 1.00 15.77 ? 216 ALA B N   1 
ATOM   2929 C CA  . ALA B 2 216 ? 228.132 258.599 377.997 1.00 12.06 ? 216 ALA B CA  1 
ATOM   2930 C C   . ALA B 2 216 ? 228.205 257.327 377.165 1.00 6.37  ? 216 ALA B C   1 
ATOM   2931 O O   . ALA B 2 216 ? 227.675 257.300 376.051 1.00 13.60 ? 216 ALA B O   1 
ATOM   2932 C CB  . ALA B 2 216 ? 229.092 259.643 377.427 1.00 12.69 ? 216 ALA B CB  1 
ATOM   2933 N N   . ASN B 2 217 ? 228.835 256.277 377.684 1.00 12.18 ? 217 ASN B N   1 
ATOM   2934 C CA  . ASN B 2 217 ? 229.009 255.013 376.972 1.00 10.84 ? 217 ASN B CA  1 
ATOM   2935 C C   . ASN B 2 217 ? 228.501 253.883 377.860 1.00 6.39  ? 217 ASN B C   1 
ATOM   2936 O O   . ASN B 2 217 ? 229.286 253.100 378.407 1.00 18.30 ? 217 ASN B O   1 
ATOM   2937 C CB  . ASN B 2 217 ? 230.474 254.810 376.587 1.00 13.12 ? 217 ASN B CB  1 
ATOM   2938 C CG  . ASN B 2 217 ? 230.943 255.803 375.543 1.00 12.25 ? 217 ASN B CG  1 
ATOM   2939 O OD1 . ASN B 2 217 ? 230.740 255.602 374.348 1.00 18.96 ? 217 ASN B OD1 1 
ATOM   2940 N ND2 . ASN B 2 217 ? 231.570 256.885 375.990 1.00 13.06 ? 217 ASN B ND2 1 
ATOM   2941 N N   . PRO B 2 218 ? 227.179 253.775 378.030 1.00 17.03 ? 218 PRO B N   1 
ATOM   2942 C CA  . PRO B 2 218 ? 226.637 252.742 378.928 1.00 13.75 ? 218 PRO B CA  1 
ATOM   2943 C C   . PRO B 2 218 ? 226.756 251.325 378.393 1.00 12.30 ? 218 PRO B C   1 
ATOM   2944 O O   . PRO B 2 218 ? 226.590 250.378 379.169 1.00 18.29 ? 218 PRO B O   1 
ATOM   2945 C CB  . PRO B 2 218 ? 225.168 253.152 379.081 1.00 10.73 ? 218 PRO B CB  1 
ATOM   2946 C CG  . PRO B 2 218 ? 224.856 253.867 377.815 1.00 12.06 ? 218 PRO B CG  1 
ATOM   2947 C CD  . PRO B 2 218 ? 226.114 254.602 377.439 1.00 9.41  ? 218 PRO B CD  1 
ATOM   2948 N N   . GLY B 2 219 ? 227.030 251.143 377.105 1.00 13.69 ? 219 GLY B N   1 
ATOM   2949 C CA  . GLY B 2 219 ? 227.085 249.813 376.533 1.00 11.81 ? 219 GLY B CA  1 
ATOM   2950 C C   . GLY B 2 219 ? 225.731 249.315 376.067 1.00 11.80 ? 219 GLY B C   1 
ATOM   2951 O O   . GLY B 2 219 ? 224.856 250.116 375.728 1.00 11.37 ? 219 GLY B O   1 
ATOM   2952 N N   . GLU B 2 220 ? 225.541 247.993 376.055 1.00 11.17 ? 220 GLU B N   1 
ATOM   2953 C CA  . GLU B 2 220 ? 224.311 247.426 375.506 1.00 11.30 ? 220 GLU B CA  1 
ATOM   2954 C C   . GLU B 2 220 ? 223.078 247.852 376.295 1.00 10.37 ? 220 GLU B C   1 
ATOM   2955 O O   . GLU B 2 220 ? 221.980 247.921 375.733 1.00 16.83 ? 220 GLU B O   1 
ATOM   2956 C CB  . GLU B 2 220 ? 224.402 245.899 375.460 1.00 9.58  ? 220 GLU B CB  1 
ATOM   2957 C CG  . GLU B 2 220 ? 224.515 245.228 376.821 1.00 11.14 ? 220 GLU B CG  1 
ATOM   2958 C CD  . GLU B 2 220 ? 224.303 243.725 376.753 1.00 22.33 ? 220 GLU B CD  1 
ATOM   2959 O OE1 . GLU B 2 220 ? 223.479 243.272 375.931 1.00 19.14 ? 220 GLU B OE1 1 
ATOM   2960 O OE2 . GLU B 2 220 ? 224.962 242.997 377.523 1.00 26.67 ? 220 GLU B OE2 1 
ATOM   2961 N N   . LYS B 2 221 ? 223.224 248.128 377.592 1.00 10.82 ? 221 LYS B N   1 
ATOM   2962 C CA  . LYS B 2 221 ? 222.055 248.497 378.382 1.00 10.19 ? 221 LYS B CA  1 
ATOM   2963 C C   . LYS B 2 221 ? 221.473 249.830 377.932 1.00 12.39 ? 221 LYS B C   1 
ATOM   2964 O O   . LYS B 2 221 ? 220.280 250.080 378.132 1.00 13.65 ? 221 LYS B O   1 
ATOM   2965 C CB  . LYS B 2 221 ? 222.409 248.550 379.868 1.00 9.95  ? 221 LYS B CB  1 
ATOM   2966 C CG  . LYS B 2 221 ? 223.341 249.680 380.259 1.00 16.40 ? 221 LYS B CG  1 
ATOM   2967 C CD  . LYS B 2 221 ? 223.647 249.637 381.747 1.00 16.68 ? 221 LYS B CD  1 
ATOM   2968 C CE  . LYS B 2 221 ? 224.650 250.702 382.149 1.00 14.13 ? 221 LYS B CE  1 
ATOM   2969 N NZ  . LYS B 2 221 ? 224.097 252.075 382.021 1.00 24.22 ? 221 LYS B NZ  1 
ATOM   2970 N N   . GLY B 2 222 ? 222.289 250.692 377.332 1.00 8.03  ? 222 GLY B N   1 
ATOM   2971 C CA  . GLY B 2 222 ? 221.796 251.972 376.874 1.00 12.24 ? 222 GLY B CA  1 
ATOM   2972 C C   . GLY B 2 222 ? 221.344 252.848 378.033 1.00 4.30  ? 222 GLY B C   1 
ATOM   2973 O O   . GLY B 2 222 ? 221.760 252.689 379.182 1.00 16.73 ? 222 GLY B O   1 
ATOM   2974 N N   . GLY B 2 223 ? 220.463 253.792 377.705 1.00 6.21  ? 223 GLY B N   1 
ATOM   2975 C CA  . GLY B 2 223 ? 219.875 254.671 378.693 1.00 6.99  ? 223 GLY B CA  1 
ATOM   2976 C C   . GLY B 2 223 ? 218.431 254.977 378.349 1.00 6.44  ? 223 GLY B C   1 
ATOM   2977 O O   . GLY B 2 223 ? 217.918 254.551 377.313 1.00 14.13 ? 223 GLY B O   1 
ATOM   2978 N N   . GLU B 2 224 ? 217.787 255.728 379.235 1.00 8.91  ? 224 GLU B N   1 
ATOM   2979 C CA  . GLU B 2 224 ? 216.383 256.072 379.092 1.00 11.32 ? 224 GLU B CA  1 
ATOM   2980 C C   . GLU B 2 224 ? 216.198 257.582 379.082 1.00 9.32  ? 224 GLU B C   1 
ATOM   2981 O O   . GLU B 2 224 ? 216.928 258.320 379.747 1.00 13.86 ? 224 GLU B O   1 
ATOM   2982 C CB  . GLU B 2 224 ? 215.547 255.462 380.220 1.00 6.24  ? 224 GLU B CB  1 
ATOM   2983 C CG  . GLU B 2 224 ? 215.498 253.949 380.190 1.00 9.19  ? 224 GLU B CG  1 
ATOM   2984 C CD  . GLU B 2 224 ? 214.664 253.368 381.311 1.00 17.48 ? 224 GLU B CD  1 
ATOM   2985 O OE1 . GLU B 2 224 ? 214.194 254.143 382.169 1.00 22.83 ? 224 GLU B OE1 1 
ATOM   2986 O OE2 . GLU B 2 224 ? 214.476 252.134 381.336 1.00 23.28 ? 224 GLU B OE2 1 
ATOM   2987 N N   . PHE B 2 225 ? 215.215 258.031 378.309 1.00 12.03 ? 225 PHE B N   1 
ATOM   2988 C CA  . PHE B 2 225 ? 214.791 259.419 378.344 1.00 7.29  ? 225 PHE B CA  1 
ATOM   2989 C C   . PHE B 2 225 ? 213.966 259.685 379.598 1.00 4.19  ? 225 PHE B C   1 
ATOM   2990 O O   . PHE B 2 225 ? 213.380 258.778 380.193 1.00 11.28 ? 225 PHE B O   1 
ATOM   2991 C CB  . PHE B 2 225 ? 213.972 259.770 377.102 1.00 6.70  ? 225 PHE B CB  1 
ATOM   2992 C CG  . PHE B 2 225 ? 214.764 259.775 375.829 1.00 5.68  ? 225 PHE B CG  1 
ATOM   2993 C CD1 . PHE B 2 225 ? 214.940 258.609 375.102 1.00 8.00  ? 225 PHE B CD1 1 
ATOM   2994 C CD2 . PHE B 2 225 ? 215.326 260.947 375.354 1.00 12.24 ? 225 PHE B CD2 1 
ATOM   2995 C CE1 . PHE B 2 225 ? 215.665 258.613 373.929 1.00 11.02 ? 225 PHE B CE1 1 
ATOM   2996 C CE2 . PHE B 2 225 ? 216.053 260.956 374.182 1.00 13.65 ? 225 PHE B CE2 1 
ATOM   2997 C CZ  . PHE B 2 225 ? 216.223 259.788 373.469 1.00 8.75  ? 225 PHE B CZ  1 
ATOM   2998 N N   . LYS B 2 226 ? 213.922 260.950 379.995 1.00 18.71 ? 226 LYS B N   1 
ATOM   2999 C CA  . LYS B 2 226 ? 213.152 261.389 381.147 1.00 8.85  ? 226 LYS B CA  1 
ATOM   3000 C C   . LYS B 2 226 ? 212.000 262.280 380.703 1.00 9.42  ? 226 LYS B C   1 
ATOM   3001 O O   . LYS B 2 226 ? 212.024 262.877 379.623 1.00 14.55 ? 226 LYS B O   1 
ATOM   3002 C CB  . LYS B 2 226 ? 214.036 262.144 382.144 1.00 17.07 ? 226 LYS B CB  1 
ATOM   3003 C CG  . LYS B 2 226 ? 215.169 261.321 382.729 1.00 16.47 ? 226 LYS B CG  1 
ATOM   3004 C CD  . LYS B 2 226 ? 216.127 262.207 383.503 1.00 16.27 ? 226 LYS B CD  1 
ATOM   3005 C CE  . LYS B 2 226 ? 217.321 261.431 384.021 1.00 21.33 ? 226 LYS B CE  1 
ATOM   3006 N NZ  . LYS B 2 226 ? 218.236 262.290 384.817 1.00 25.27 ? 226 LYS B NZ  1 
ATOM   3007 N N   . GLY B 2 227 ? 210.977 262.350 381.553 1.00 15.66 ? 227 GLY B N   1 
ATOM   3008 C CA  . GLY B 2 227 ? 209.867 263.248 381.285 1.00 10.71 ? 227 GLY B CA  1 
ATOM   3009 C C   . GLY B 2 227 ? 210.249 264.710 381.409 1.00 15.38 ? 227 GLY B C   1 
ATOM   3010 O O   . GLY B 2 227 ? 209.821 265.543 380.606 1.00 20.62 ? 227 GLY B O   1 
ATOM   3011 N N   . SER B 2 228 ? 211.060 265.044 382.412 1.00 15.98 ? 228 SER B N   1 
ATOM   3012 C CA  . SER B 2 228 ? 211.431 266.425 382.681 1.00 18.92 ? 228 SER B CA  1 
ATOM   3013 C C   . SER B 2 228 ? 212.918 266.502 382.992 1.00 16.04 ? 228 SER B C   1 
ATOM   3014 O O   . SER B 2 228 ? 213.594 265.488 383.177 1.00 22.34 ? 228 SER B O   1 
ATOM   3015 C CB  . SER B 2 228 ? 210.614 267.009 383.842 1.00 22.22 ? 228 SER B CB  1 
ATOM   3016 O OG  . SER B 2 228 ? 210.820 266.271 385.033 1.00 21.94 ? 228 SER B OG  1 
ATOM   3017 N N   . PHE B 2 229 ? 213.423 267.730 383.045 1.00 18.04 ? 229 PHE B N   1 
ATOM   3018 C CA  . PHE B 2 229 ? 214.826 267.983 383.340 1.00 16.13 ? 229 PHE B CA  1 
ATOM   3019 C C   . PHE B 2 229 ? 215.012 268.168 384.839 1.00 15.90 ? 229 PHE B C   1 
ATOM   3020 O O   . PHE B 2 229 ? 214.336 268.994 385.458 1.00 24.02 ? 229 PHE B O   1 
ATOM   3021 C CB  . PHE B 2 229 ? 215.315 269.219 382.585 1.00 14.52 ? 229 PHE B CB  1 
ATOM   3022 C CG  . PHE B 2 229 ? 216.737 269.592 382.888 1.00 19.66 ? 229 PHE B CG  1 
ATOM   3023 C CD1 . PHE B 2 229 ? 217.789 268.869 382.351 1.00 16.73 ? 229 PHE B CD1 1 
ATOM   3024 C CD2 . PHE B 2 229 ? 217.022 270.670 383.706 1.00 14.04 ? 229 PHE B CD2 1 
ATOM   3025 C CE1 . PHE B 2 229 ? 219.097 269.212 382.630 1.00 17.02 ? 229 PHE B CE1 1 
ATOM   3026 C CE2 . PHE B 2 229 ? 218.327 271.019 383.986 1.00 20.32 ? 229 PHE B CE2 1 
ATOM   3027 C CZ  . PHE B 2 229 ? 219.366 270.289 383.447 1.00 22.16 ? 229 PHE B CZ  1 
ATOM   3028 N N   . THR B 2 230 ? 215.925 267.393 385.417 1.00 17.56 ? 230 THR B N   1 
ATOM   3029 C CA  . THR B 2 230 ? 216.293 267.504 386.825 1.00 21.06 ? 230 THR B CA  1 
ATOM   3030 C C   . THR B 2 230 ? 217.768 267.875 386.902 1.00 20.98 ? 230 THR B C   1 
ATOM   3031 O O   . THR B 2 230 ? 218.638 267.056 386.586 1.00 23.35 ? 230 THR B O   1 
ATOM   3032 C CB  . THR B 2 230 ? 216.018 266.199 387.572 1.00 20.84 ? 230 THR B CB  1 
ATOM   3033 O OG1 . THR B 2 230 ? 214.617 265.902 387.522 1.00 26.19 ? 230 THR B OG1 1 
ATOM   3034 C CG2 . THR B 2 230 ? 216.461 266.309 389.027 1.00 22.30 ? 230 THR B CG2 1 
ATOM   3035 N N   . LEU B 2 231 ? 218.045 269.107 387.313 1.00 19.49 ? 231 LEU B N   1 
ATOM   3036 C CA  . LEU B 2 231 ? 219.419 269.545 387.498 1.00 22.58 ? 231 LEU B CA  1 
ATOM   3037 C C   . LEU B 2 231 ? 220.051 268.811 388.674 1.00 25.91 ? 231 LEU B C   1 
ATOM   3038 O O   . LEU B 2 231 ? 219.459 268.706 389.750 1.00 31.05 ? 231 LEU B O   1 
ATOM   3039 C CB  . LEU B 2 231 ? 219.460 271.054 387.731 1.00 24.39 ? 231 LEU B CB  1 
ATOM   3040 C CG  . LEU B 2 231 ? 220.838 271.694 387.887 1.00 25.97 ? 231 LEU B CG  1 
ATOM   3041 C CD1 . LEU B 2 231 ? 221.604 271.642 386.573 1.00 23.87 ? 231 LEU B CD1 1 
ATOM   3042 C CD2 . LEU B 2 231 ? 220.696 273.124 388.380 1.00 27.09 ? 231 LEU B CD2 1 
ATOM   3043 N N   . ASP B 2 232 ? 221.262 268.300 388.464 1.00 25.91 ? 232 ASP B N   1 
ATOM   3044 C CA  . ASP B 2 232 ? 221.991 267.577 389.501 1.00 26.98 ? 232 ASP B CA  1 
ATOM   3045 C C   . ASP B 2 232 ? 222.683 268.593 390.403 1.00 29.28 ? 232 ASP B C   1 
ATOM   3046 O O   . ASP B 2 232 ? 223.593 269.305 389.966 1.00 32.09 ? 232 ASP B O   1 
ATOM   3047 C CB  . ASP B 2 232 ? 222.995 266.609 388.880 1.00 25.12 ? 232 ASP B CB  1 
ATOM   3048 C CG  . ASP B 2 232 ? 223.904 265.969 389.910 1.00 31.55 ? 232 ASP B CG  1 
ATOM   3049 O OD1 . ASP B 2 232 ? 223.391 265.466 390.930 1.00 31.66 ? 232 ASP B OD1 1 
ATOM   3050 O OD2 . ASP B 2 232 ? 225.133 265.963 389.695 1.00 31.84 ? 232 ASP B OD2 1 
ATOM   3051 N N   . THR B 2 233 ? 222.248 268.663 391.659 1.00 31.96 ? 233 THR B N   1 
ATOM   3052 C CA  . THR B 2 233 ? 222.741 269.655 392.605 1.00 34.50 ? 233 THR B CA  1 
ATOM   3053 C C   . THR B 2 233 ? 223.840 269.125 393.517 1.00 36.14 ? 233 THR B C   1 
ATOM   3054 O O   . THR B 2 233 ? 224.319 269.870 394.377 1.00 35.93 ? 233 THR B O   1 
ATOM   3055 C CB  . THR B 2 233 ? 221.586 270.183 393.462 1.00 33.82 ? 233 THR B CB  1 
ATOM   3056 O OG1 . THR B 2 233 ? 221.003 269.104 394.204 1.00 36.97 ? 233 THR B OG1 1 
ATOM   3057 C CG2 . THR B 2 233 ? 220.521 270.828 392.589 1.00 33.27 ? 233 THR B CG2 1 
ATOM   3058 N N   . ASN B 2 234 ? 224.252 267.869 393.358 1.00 37.95 ? 234 ASN B N   1 
ATOM   3059 C CA  . ASN B 2 234 ? 225.304 267.300 394.195 1.00 35.31 ? 234 ASN B CA  1 
ATOM   3060 C C   . ASN B 2 234 ? 226.647 267.858 393.740 1.00 35.44 ? 234 ASN B C   1 
ATOM   3061 O O   . ASN B 2 234 ? 227.131 267.526 392.653 1.00 39.31 ? 234 ASN B O   1 
ATOM   3062 C CB  . ASN B 2 234 ? 225.286 265.776 394.118 1.00 35.29 ? 234 ASN B CB  1 
ATOM   3063 C CG  . ASN B 2 234 ? 226.235 265.130 395.111 1.00 37.92 ? 234 ASN B CG  1 
ATOM   3064 O OD1 . ASN B 2 234 ? 227.180 265.759 395.587 1.00 39.54 ? 234 ASN B OD1 1 
ATOM   3065 N ND2 . ASN B 2 234 ? 225.987 263.866 395.427 1.00 35.53 ? 234 ASN B ND2 1 
ATOM   3066 N N   . ALA B 2 235 ? 227.253 268.704 394.572 1.00 37.99 ? 235 ALA B N   1 
ATOM   3067 C CA  . ALA B 2 235 ? 228.541 269.304 394.250 1.00 38.74 ? 235 ALA B CA  1 
ATOM   3068 C C   . ALA B 2 235 ? 229.716 268.408 394.615 1.00 37.03 ? 235 ALA B C   1 
ATOM   3069 O O   . ALA B 2 235 ? 230.729 268.413 393.908 1.00 35.93 ? 235 ALA B O   1 
ATOM   3070 C CB  . ALA B 2 235 ? 228.690 270.649 394.966 1.00 36.42 ? 235 ALA B CB  1 
ATOM   3071 N N   . THR B 2 236 ? 229.608 267.648 395.705 1.00 38.18 ? 236 THR B N   1 
ATOM   3072 C CA  . THR B 2 236 ? 230.707 266.776 396.110 1.00 37.30 ? 236 THR B CA  1 
ATOM   3073 C C   . THR B 2 236 ? 230.922 265.656 395.100 1.00 37.73 ? 236 THR B C   1 
ATOM   3074 O O   . THR B 2 236 ? 232.044 265.439 394.627 1.00 39.09 ? 236 THR B O   1 
ATOM   3075 C CB  . THR B 2 236 ? 230.428 266.194 397.497 1.00 38.85 ? 236 THR B CB  1 
ATOM   3076 O OG1 . THR B 2 236 ? 230.448 267.241 398.475 1.00 41.05 ? 236 THR B OG1 1 
ATOM   3077 C CG2 . THR B 2 236 ? 231.468 265.140 397.857 1.00 37.92 ? 236 THR B CG2 1 
ATOM   3078 N N   . ASN B 2 237 ? 229.856 264.943 394.749 1.00 37.11 ? 237 ASN B N   1 
ATOM   3079 C CA  . ASN B 2 237 ? 229.929 263.763 393.889 1.00 35.03 ? 237 ASN B CA  1 
ATOM   3080 C C   . ASN B 2 237 ? 228.907 263.909 392.770 1.00 32.41 ? 237 ASN B C   1 
ATOM   3081 O O   . ASN B 2 237 ? 227.890 263.206 392.741 1.00 33.65 ? 237 ASN B O   1 
ATOM   3082 C CB  . ASN B 2 237 ? 229.686 262.489 394.701 1.00 35.19 ? 237 ASN B CB  1 
ATOM   3083 C CG  . ASN B 2 237 ? 229.714 261.238 393.847 1.00 37.96 ? 237 ASN B CG  1 
ATOM   3084 O OD1 . ASN B 2 237 ? 230.295 261.224 392.762 1.00 39.74 ? 237 ASN B OD1 1 
ATOM   3085 N ND2 . ASN B 2 237 ? 229.080 260.177 394.333 1.00 36.37 ? 237 ASN B ND2 1 
ATOM   3086 N N   . PRO B 2 238 ? 229.146 264.819 391.829 1.00 29.55 ? 238 PRO B N   1 
ATOM   3087 C CA  . PRO B 2 238 ? 228.169 265.032 390.756 1.00 29.12 ? 238 PRO B CA  1 
ATOM   3088 C C   . PRO B 2 238 ? 227.962 263.765 389.941 1.00 22.59 ? 238 PRO B C   1 
ATOM   3089 O O   . PRO B 2 238 ? 228.908 263.037 389.635 1.00 28.82 ? 238 PRO B O   1 
ATOM   3090 C CB  . PRO B 2 238 ? 228.797 266.153 389.920 1.00 26.38 ? 238 PRO B CB  1 
ATOM   3091 C CG  . PRO B 2 238 ? 230.248 266.086 390.219 1.00 25.43 ? 238 PRO B CG  1 
ATOM   3092 C CD  . PRO B 2 238 ? 230.359 265.631 391.640 1.00 27.66 ? 238 PRO B CD  1 
ATOM   3093 N N   . ALA B 2 239 ? 226.702 263.509 389.586 1.00 28.61 ? 239 ALA B N   1 
ATOM   3094 C CA  . ALA B 2 239 ? 226.385 262.327 388.793 1.00 21.93 ? 239 ALA B CA  1 
ATOM   3095 C C   . ALA B 2 239 ? 227.088 262.368 387.443 1.00 20.93 ? 239 ALA B C   1 
ATOM   3096 O O   . ALA B 2 239 ? 227.498 261.327 386.917 1.00 23.47 ? 239 ALA B O   1 
ATOM   3097 C CB  . ALA B 2 239 ? 224.873 262.211 388.608 1.00 23.15 ? 239 ALA B CB  1 
ATOM   3098 N N   . ARG B 2 240 ? 227.231 263.559 386.866 1.00 19.39 ? 240 ARG B N   1 
ATOM   3099 C CA  . ARG B 2 240 ? 227.894 263.737 385.577 1.00 19.35 ? 240 ARG B CA  1 
ATOM   3100 C C   . ARG B 2 240 ? 227.302 262.798 384.530 1.00 17.68 ? 240 ARG B C   1 
ATOM   3101 O O   . ARG B 2 240 ? 228.013 262.115 383.791 1.00 19.37 ? 240 ARG B O   1 
ATOM   3102 C CB  . ARG B 2 240 ? 229.402 263.531 385.707 1.00 18.59 ? 240 ARG B CB  1 
ATOM   3103 C CG  . ARG B 2 240 ? 230.078 264.516 386.643 1.00 20.52 ? 240 ARG B CG  1 
ATOM   3104 C CD  . ARG B 2 240 ? 231.584 264.400 386.557 1.00 17.94 ? 240 ARG B CD  1 
ATOM   3105 N NE  . ARG B 2 240 ? 232.072 264.720 385.222 1.00 20.84 ? 240 ARG B NE  1 
ATOM   3106 C CZ  . ARG B 2 240 ? 233.291 264.440 384.782 1.00 22.56 ? 240 ARG B CZ  1 
ATOM   3107 N NH1 . ARG B 2 240 ? 234.181 263.832 385.549 1.00 23.92 ? 240 ARG B NH1 1 
ATOM   3108 N NH2 . ARG B 2 240 ? 233.623 264.770 383.538 1.00 22.11 ? 240 ARG B NH2 1 
ATOM   3109 N N   . ASN B 2 241 ? 225.977 262.767 384.477 1.00 16.63 ? 241 ASN B N   1 
ATOM   3110 C CA  . ASN B 2 241 ? 225.247 261.878 383.591 1.00 17.91 ? 241 ASN B CA  1 
ATOM   3111 C C   . ASN B 2 241 ? 224.375 262.693 382.647 1.00 10.58 ? 241 ASN B C   1 
ATOM   3112 O O   . ASN B 2 241 ? 224.112 263.876 382.872 1.00 19.75 ? 241 ASN B O   1 
ATOM   3113 C CB  . ASN B 2 241 ? 224.382 260.899 384.393 1.00 18.30 ? 241 ASN B CB  1 
ATOM   3114 C CG  . ASN B 2 241 ? 224.003 259.670 383.596 1.00 21.37 ? 241 ASN B CG  1 
ATOM   3115 O OD1 . ASN B 2 241 ? 223.890 259.717 382.372 1.00 25.71 ? 241 ASN B OD1 1 
ATOM   3116 N ND2 . ASN B 2 241 ? 223.809 258.556 384.290 1.00 22.54 ? 241 ASN B ND2 1 
ATOM   3117 N N   . PHE B 2 242 ? 223.937 262.048 381.572 1.00 12.53 ? 242 PHE B N   1 
ATOM   3118 C CA  . PHE B 2 242 ? 222.960 262.667 380.695 1.00 10.68 ? 242 PHE B CA  1 
ATOM   3119 C C   . PHE B 2 242 ? 221.636 262.847 381.425 1.00 14.06 ? 242 PHE B C   1 
ATOM   3120 O O   . PHE B 2 242 ? 221.290 262.087 382.332 1.00 17.86 ? 242 PHE B O   1 
ATOM   3121 C CB  . PHE B 2 242 ? 222.736 261.820 379.443 1.00 13.35 ? 242 PHE B CB  1 
ATOM   3122 C CG  . PHE B 2 242 ? 223.905 261.793 378.504 1.00 14.80 ? 242 PHE B CG  1 
ATOM   3123 C CD1 . PHE B 2 242 ? 224.642 262.938 378.248 1.00 8.71  ? 242 PHE B CD1 1 
ATOM   3124 C CD2 . PHE B 2 242 ? 224.263 260.618 377.869 1.00 9.16  ? 242 PHE B CD2 1 
ATOM   3125 C CE1 . PHE B 2 242 ? 225.713 262.907 377.380 1.00 10.71 ? 242 PHE B CE1 1 
ATOM   3126 C CE2 . PHE B 2 242 ? 225.332 260.584 377.001 1.00 10.64 ? 242 PHE B CE2 1 
ATOM   3127 C CZ  . PHE B 2 242 ? 226.058 261.730 376.758 1.00 11.01 ? 242 PHE B CZ  1 
ATOM   3128 N N   . CYS B 2 243 ? 220.899 263.877 381.025 1.00 17.34 ? 243 CYS B N   1 
ATOM   3129 C CA  . CYS B 2 243 ? 219.513 264.078 381.444 1.00 14.68 ? 243 CYS B CA  1 
ATOM   3130 C C   . CYS B 2 243 ? 218.685 264.344 380.195 1.00 13.16 ? 243 CYS B C   1 
ATOM   3131 O O   . CYS B 2 243 ? 218.217 265.466 379.969 1.00 15.13 ? 243 CYS B O   1 
ATOM   3132 C CB  . CYS B 2 243 ? 219.395 265.226 382.445 1.00 14.42 ? 243 CYS B CB  1 
ATOM   3133 S SG  . CYS B 2 243 ? 217.723 265.480 383.063 1.00 29.53 ? 243 CYS B SG  1 
ATOM   3134 N N   . PRO B 2 244 ? 218.489 263.329 379.354 1.00 11.76 ? 244 PRO B N   1 
ATOM   3135 C CA  . PRO B 2 244 ? 217.816 263.542 378.067 1.00 11.26 ? 244 PRO B CA  1 
ATOM   3136 C C   . PRO B 2 244 ? 216.304 263.573 378.234 1.00 12.29 ? 244 PRO B C   1 
ATOM   3137 O O   . PRO B 2 244 ? 215.679 262.564 378.572 1.00 14.20 ? 244 PRO B O   1 
ATOM   3138 C CB  . PRO B 2 244 ? 218.280 262.340 377.229 1.00 8.18  ? 244 PRO B CB  1 
ATOM   3139 C CG  . PRO B 2 244 ? 219.042 261.423 378.179 1.00 14.42 ? 244 PRO B CG  1 
ATOM   3140 C CD  . PRO B 2 244 ? 218.804 261.908 379.562 1.00 5.94  ? 244 PRO B CD  1 
ATOM   3141 N N   . VAL B 2 245 ? 215.714 264.737 377.991 1.00 9.23  ? 245 VAL B N   1 
ATOM   3142 C CA  . VAL B 2 245 ? 214.272 264.912 378.116 1.00 10.98 ? 245 VAL B CA  1 
ATOM   3143 C C   . VAL B 2 245 ? 213.602 264.480 376.820 1.00 7.54  ? 245 VAL B C   1 
ATOM   3144 O O   . VAL B 2 245 ? 214.066 264.806 375.722 1.00 11.51 ? 245 VAL B O   1 
ATOM   3145 C CB  . VAL B 2 245 ? 213.939 266.372 378.472 1.00 14.75 ? 245 VAL B CB  1 
ATOM   3146 C CG1 . VAL B 2 245 ? 212.438 266.587 378.480 1.00 9.26  ? 245 VAL B CG1 1 
ATOM   3147 C CG2 . VAL B 2 245 ? 214.546 266.737 379.824 1.00 11.87 ? 245 VAL B CG2 1 
ATOM   3148 N N   . ASP B 2 246 ? 212.502 263.734 376.949 1.00 8.93  ? 246 ASP B N   1 
ATOM   3149 C CA  . ASP B 2 246 ? 211.911 263.064 375.793 1.00 10.75 ? 246 ASP B CA  1 
ATOM   3150 C C   . ASP B 2 246 ? 211.392 264.062 374.762 1.00 6.14  ? 246 ASP B C   1 
ATOM   3151 O O   . ASP B 2 246 ? 211.710 263.958 373.573 1.00 7.93  ? 246 ASP B O   1 
ATOM   3152 C CB  . ASP B 2 246 ? 210.792 262.126 376.248 1.00 8.59  ? 246 ASP B CB  1 
ATOM   3153 C CG  . ASP B 2 246 ? 209.799 262.799 377.175 1.00 11.97 ? 246 ASP B CG  1 
ATOM   3154 O OD1 . ASP B 2 246 ? 209.821 264.042 377.287 1.00 22.15 ? 246 ASP B OD1 1 
ATOM   3155 O OD2 . ASP B 2 246 ? 209.002 262.079 377.802 1.00 16.09 ? 246 ASP B OD2 1 
ATOM   3156 N N   . TYR B 2 247 ? 210.582 265.033 375.192 1.00 4.91  ? 247 TYR B N   1 
ATOM   3157 C CA  . TYR B 2 247 ? 210.005 265.968 374.231 1.00 9.18  ? 247 TYR B CA  1 
ATOM   3158 C C   . TYR B 2 247 ? 211.048 266.928 373.671 1.00 12.28 ? 247 TYR B C   1 
ATOM   3159 O O   . TYR B 2 247 ? 210.810 267.538 372.625 1.00 14.81 ? 247 TYR B O   1 
ATOM   3160 C CB  . TYR B 2 247 ? 208.841 266.741 374.863 1.00 8.75  ? 247 TYR B CB  1 
ATOM   3161 C CG  . TYR B 2 247 ? 209.241 267.786 375.876 1.00 8.94  ? 247 TYR B CG  1 
ATOM   3162 C CD1 . TYR B 2 247 ? 209.517 269.090 375.484 1.00 10.70 ? 247 TYR B CD1 1 
ATOM   3163 C CD2 . TYR B 2 247 ? 209.330 267.476 377.225 1.00 9.39  ? 247 TYR B CD2 1 
ATOM   3164 C CE1 . TYR B 2 247 ? 209.880 270.049 376.403 1.00 10.33 ? 247 TYR B CE1 1 
ATOM   3165 C CE2 . TYR B 2 247 ? 209.695 268.429 378.152 1.00 11.83 ? 247 TYR B CE2 1 
ATOM   3166 C CZ  . TYR B 2 247 ? 209.969 269.714 377.735 1.00 10.31 ? 247 TYR B CZ  1 
ATOM   3167 O OH  . TYR B 2 247 ? 210.329 270.668 378.653 1.00 17.69 ? 247 TYR B OH  1 
ATOM   3168 N N   . LEU B 2 248 ? 212.197 267.062 374.327 1.00 5.77  ? 248 LEU B N   1 
ATOM   3169 C CA  . LEU B 2 248 ? 213.335 267.773 373.764 1.00 6.38  ? 248 LEU B CA  1 
ATOM   3170 C C   . LEU B 2 248 ? 214.295 266.838 373.037 1.00 8.41  ? 248 LEU B C   1 
ATOM   3171 O O   . LEU B 2 248 ? 215.395 267.260 372.670 1.00 6.95  ? 248 LEU B O   1 
ATOM   3172 C CB  . LEU B 2 248 ? 214.073 268.541 374.864 1.00 9.64  ? 248 LEU B CB  1 
ATOM   3173 C CG  . LEU B 2 248 ? 213.214 269.577 375.595 1.00 6.56  ? 248 LEU B CG  1 
ATOM   3174 C CD1 . LEU B 2 248 ? 214.021 270.297 376.661 1.00 12.36 ? 248 LEU B CD1 1 
ATOM   3175 C CD2 . LEU B 2 248 ? 212.600 270.573 374.615 1.00 8.08  ? 248 LEU B CD2 1 
ATOM   3176 N N   . PHE B 2 249 ? 213.894 265.584 372.819 1.00 7.93  ? 249 PHE B N   1 
ATOM   3177 C CA  . PHE B 2 249 ? 214.714 264.595 372.120 1.00 6.28  ? 249 PHE B CA  1 
ATOM   3178 C C   . PHE B 2 249 ? 216.100 264.484 372.746 1.00 7.97  ? 249 PHE B C   1 
ATOM   3179 O O   . PHE B 2 249 ? 217.080 264.154 372.075 1.00 9.12  ? 249 PHE B O   1 
ATOM   3180 C CB  . PHE B 2 249 ? 214.812 264.920 370.627 1.00 5.02  ? 249 PHE B CB  1 
ATOM   3181 C CG  . PHE B 2 249 ? 215.178 263.742 369.768 1.00 9.06  ? 249 PHE B CG  1 
ATOM   3182 C CD1 . PHE B 2 249 ? 214.411 262.586 369.783 1.00 12.88 ? 249 PHE B CD1 1 
ATOM   3183 C CD2 . PHE B 2 249 ? 216.276 263.798 368.929 1.00 3.33  ? 249 PHE B CD2 1 
ATOM   3184 C CE1 . PHE B 2 249 ? 214.743 261.505 368.990 1.00 5.41  ? 249 PHE B CE1 1 
ATOM   3185 C CE2 . PHE B 2 249 ? 216.612 262.722 368.134 1.00 4.98  ? 249 PHE B CE2 1 
ATOM   3186 C CZ  . PHE B 2 249 ? 215.843 261.573 368.163 1.00 7.33  ? 249 PHE B CZ  1 
ATOM   3187 N N   . GLY B 2 250 ? 216.185 264.770 374.042 1.00 8.47  ? 250 GLY B N   1 
ATOM   3188 C CA  . GLY B 2 250 ? 217.418 264.658 374.786 1.00 5.59  ? 250 GLY B CA  1 
ATOM   3189 C C   . GLY B 2 250 ? 218.492 265.660 374.425 1.00 10.34 ? 250 GLY B C   1 
ATOM   3190 O O   . GLY B 2 250 ? 219.576 265.606 375.012 1.00 16.27 ? 250 GLY B O   1 
ATOM   3191 N N   . SER B 2 251 ? 218.233 266.574 373.483 1.00 10.28 ? 251 SER B N   1 
ATOM   3192 C CA  . SER B 2 251 ? 219.261 267.509 373.043 1.00 11.93 ? 251 SER B CA  1 
ATOM   3193 C C   . SER B 2 251 ? 218.720 268.914 372.785 1.00 7.29  ? 251 SER B C   1 
ATOM   3194 O O   . SER B 2 251 ? 219.355 269.686 372.059 1.00 23.26 ? 251 SER B O   1 
ATOM   3195 C CB  . SER B 2 251 ? 219.949 266.985 371.782 1.00 10.65 ? 251 SER B CB  1 
ATOM   3196 O OG  . SER B 2 251 ? 219.007 266.681 370.770 1.00 12.72 ? 251 SER B OG  1 
ATOM   3197 N N   . GLY B 2 252 ? 217.574 269.271 373.356 1.00 14.03 ? 252 GLY B N   1 
ATOM   3198 C CA  . GLY B 2 252 ? 217.051 270.612 373.188 1.00 9.34  ? 252 GLY B CA  1 
ATOM   3199 C C   . GLY B 2 252 ? 216.401 270.888 371.851 1.00 9.11  ? 252 GLY B C   1 
ATOM   3200 O O   . GLY B 2 252 ? 216.412 272.033 371.393 1.00 14.60 ? 252 GLY B O   1 
ATOM   3201 N N   . VAL B 2 253 ? 215.838 269.869 371.207 1.00 9.25  ? 253 VAL B N   1 
ATOM   3202 C CA  . VAL B 2 253 ? 215.067 270.030 369.981 1.00 6.20  ? 253 VAL B CA  1 
ATOM   3203 C C   . VAL B 2 253 ? 213.738 269.317 370.171 1.00 6.71  ? 253 VAL B C   1 
ATOM   3204 O O   . VAL B 2 253 ? 213.656 268.300 370.863 1.00 20.46 ? 253 VAL B O   1 
ATOM   3205 C CB  . VAL B 2 253 ? 215.805 269.472 368.745 1.00 7.47  ? 253 VAL B CB  1 
ATOM   3206 C CG1 . VAL B 2 253 ? 217.182 270.103 368.603 1.00 10.72 ? 253 VAL B CG1 1 
ATOM   3207 C CG2 . VAL B 2 253 ? 215.900 267.952 368.829 1.00 9.76  ? 253 VAL B CG2 1 
ATOM   3208 N N   . LEU B 2 254 ? 212.692 269.839 369.541 1.00 5.16  ? 254 LEU B N   1 
ATOM   3209 C CA  . LEU B 2 254 ? 211.379 269.233 369.707 1.00 5.62  ? 254 LEU B CA  1 
ATOM   3210 C C   . LEU B 2 254 ? 211.373 267.822 369.136 1.00 8.24  ? 254 LEU B C   1 
ATOM   3211 O O   . LEU B 2 254 ? 211.842 267.584 368.020 1.00 10.38 ? 254 LEU B O   1 
ATOM   3212 C CB  . LEU B 2 254 ? 210.304 270.086 369.038 1.00 10.00 ? 254 LEU B CB  1 
ATOM   3213 C CG  . LEU B 2 254 ? 210.073 271.467 369.653 1.00 9.47  ? 254 LEU B CG  1 
ATOM   3214 C CD1 . LEU B 2 254 ? 208.831 272.088 369.056 1.00 15.17 ? 254 LEU B CD1 1 
ATOM   3215 C CD2 . LEU B 2 254 ? 209.962 271.404 371.170 1.00 6.81  ? 254 LEU B CD2 1 
ATOM   3216 N N   . ALA B 2 255 ? 210.827 266.884 369.913 1.00 9.04  ? 255 ALA B N   1 
ATOM   3217 C CA  . ALA B 2 255 ? 210.820 265.487 369.497 1.00 8.12  ? 255 ALA B CA  1 
ATOM   3218 C C   . ALA B 2 255 ? 210.054 265.290 368.198 1.00 7.72  ? 255 ALA B C   1 
ATOM   3219 O O   . ALA B 2 255 ? 210.415 264.426 367.393 1.00 10.88 ? 255 ALA B O   1 
ATOM   3220 C CB  . ALA B 2 255 ? 210.222 264.616 370.602 1.00 11.00 ? 255 ALA B CB  1 
ATOM   3221 N N   . GLY B 2 256 ? 209.006 266.083 367.968 1.00 10.59 ? 256 GLY B N   1 
ATOM   3222 C CA  . GLY B 2 256 ? 208.226 265.945 366.752 1.00 6.23  ? 256 GLY B CA  1 
ATOM   3223 C C   . GLY B 2 256 ? 209.033 266.129 365.485 1.00 1.82  ? 256 GLY B C   1 
ATOM   3224 O O   . GLY B 2 256 ? 208.652 265.600 364.438 1.00 5.32  ? 256 GLY B O   1 
ATOM   3225 N N   . ASN B 2 257 ? 210.140 266.862 365.555 1.00 10.55 ? 257 ASN B N   1 
ATOM   3226 C CA  . ASN B 2 257 ? 210.992 267.080 364.395 1.00 12.15 ? 257 ASN B CA  1 
ATOM   3227 C C   . ASN B 2 257 ? 212.065 266.010 364.232 1.00 3.49  ? 257 ASN B C   1 
ATOM   3228 O O   . ASN B 2 257 ? 212.761 266.006 363.211 1.00 11.27 ? 257 ASN B O   1 
ATOM   3229 C CB  . ASN B 2 257 ? 211.642 268.464 364.486 1.00 9.01  ? 257 ASN B CB  1 
ATOM   3230 C CG  . ASN B 2 257 ? 210.626 269.586 364.427 1.00 10.26 ? 257 ASN B CG  1 
ATOM   3231 O OD1 . ASN B 2 257 ? 209.657 269.519 363.675 1.00 16.51 ? 257 ASN B OD1 1 
ATOM   3232 N ND2 . ASN B 2 257 ? 210.835 270.618 365.229 1.00 10.69 ? 257 ASN B ND2 1 
ATOM   3233 N N   . ALA B 2 258 ? 212.185 265.078 365.182 1.00 2.72  ? 258 ALA B N   1 
ATOM   3234 C CA  . ALA B 2 258 ? 213.190 264.027 365.079 1.00 4.89  ? 258 ALA B CA  1 
ATOM   3235 C C   . ALA B 2 258 ? 212.974 263.136 363.865 1.00 5.27  ? 258 ALA B C   1 
ATOM   3236 O O   . ALA B 2 258 ? 213.882 262.385 363.497 1.00 12.39 ? 258 ALA B O   1 
ATOM   3237 C CB  . ALA B 2 258 ? 213.195 263.175 366.349 1.00 4.63  ? 258 ALA B CB  1 
ATOM   3238 N N   . PHE B 2 259 ? 211.799 263.202 363.240 1.00 10.57 ? 259 PHE B N   1 
ATOM   3239 C CA  . PHE B 2 259 ? 211.551 262.471 362.007 1.00 2.91  ? 259 PHE B CA  1 
ATOM   3240 C C   . PHE B 2 259 ? 212.410 262.961 360.849 1.00 0.08  ? 259 PHE B C   1 
ATOM   3241 O O   . PHE B 2 259 ? 212.471 262.280 359.821 1.00 0.01  ? 259 PHE B O   1 
ATOM   3242 C CB  . PHE B 2 259 ? 210.066 262.563 361.648 1.00 10.92 ? 259 PHE B CB  1 
ATOM   3243 C CG  . PHE B 2 259 ? 209.172 261.821 362.600 1.00 7.94  ? 259 PHE B CG  1 
ATOM   3244 C CD1 . PHE B 2 259 ? 208.731 262.418 363.767 1.00 8.61  ? 259 PHE B CD1 1 
ATOM   3245 C CD2 . PHE B 2 259 ? 208.792 260.516 362.338 1.00 8.46  ? 259 PHE B CD2 1 
ATOM   3246 C CE1 . PHE B 2 259 ? 207.920 261.734 364.647 1.00 7.73  ? 259 PHE B CE1 1 
ATOM   3247 C CE2 . PHE B 2 259 ? 207.979 259.828 363.217 1.00 10.54 ? 259 PHE B CE2 1 
ATOM   3248 C CZ  . PHE B 2 259 ? 207.544 260.438 364.371 1.00 7.88  ? 259 PHE B CZ  1 
ATOM   3249 N N   . VAL B 2 260 ? 213.075 264.114 360.977 1.00 6.53  ? 260 VAL B N   1 
ATOM   3250 C CA  . VAL B 2 260 ? 214.030 264.492 359.940 1.00 1.20  ? 260 VAL B CA  1 
ATOM   3251 C C   . VAL B 2 260 ? 215.179 263.491 359.901 1.00 4.60  ? 260 VAL B C   1 
ATOM   3252 O O   . VAL B 2 260 ? 215.800 263.286 358.851 1.00 6.16  ? 260 VAL B O   1 
ATOM   3253 C CB  . VAL B 2 260 ? 214.535 265.935 360.143 1.00 8.68  ? 260 VAL B CB  1 
ATOM   3254 C CG1 . VAL B 2 260 ? 213.359 266.922 360.187 1.00 11.03 ? 260 VAL B CG1 1 
ATOM   3255 C CG2 . VAL B 2 260 ? 215.400 266.045 361.388 1.00 8.61  ? 260 VAL B CG2 1 
ATOM   3256 N N   . TYR B 2 261 ? 215.474 262.846 361.026 1.00 1.83  ? 261 TYR B N   1 
ATOM   3257 C CA  . TYR B 2 261 ? 216.445 261.770 361.042 1.00 5.47  ? 261 TYR B CA  1 
ATOM   3258 C C   . TYR B 2 261 ? 215.864 260.521 360.383 1.00 4.90  ? 261 TYR B C   1 
ATOM   3259 O O   . TYR B 2 261 ? 214.646 260.347 360.329 1.00 9.93  ? 261 TYR B O   1 
ATOM   3260 C CB  . TYR B 2 261 ? 216.859 261.445 362.473 1.00 3.49  ? 261 TYR B CB  1 
ATOM   3261 C CG  . TYR B 2 261 ? 217.577 262.566 363.180 1.00 2.92  ? 261 TYR B CG  1 
ATOM   3262 C CD1 . TYR B 2 261 ? 218.752 263.098 362.663 1.00 1.04  ? 261 TYR B CD1 1 
ATOM   3263 C CD2 . TYR B 2 261 ? 217.091 263.086 364.372 1.00 3.75  ? 261 TYR B CD2 1 
ATOM   3264 C CE1 . TYR B 2 261 ? 219.413 264.116 363.305 1.00 3.81  ? 261 TYR B CE1 1 
ATOM   3265 C CE2 . TYR B 2 261 ? 217.752 264.103 365.024 1.00 4.38  ? 261 TYR B CE2 1 
ATOM   3266 C CZ  . TYR B 2 261 ? 218.913 264.615 364.484 1.00 2.18  ? 261 TYR B CZ  1 
ATOM   3267 O OH  . TYR B 2 261 ? 219.578 265.630 365.128 1.00 10.73 ? 261 TYR B OH  1 
ATOM   3268 N N   . PRO B 2 262 ? 216.717 259.634 359.869 1.00 6.67  ? 262 PRO B N   1 
ATOM   3269 C CA  . PRO B 2 262 ? 216.215 258.330 359.422 1.00 6.32  ? 262 PRO B CA  1 
ATOM   3270 C C   . PRO B 2 262 ? 215.480 257.636 360.557 1.00 0.99  ? 262 PRO B C   1 
ATOM   3271 O O   . PRO B 2 262 ? 215.931 257.627 361.703 1.00 8.89  ? 262 PRO B O   1 
ATOM   3272 C CB  . PRO B 2 262 ? 217.483 257.572 359.007 1.00 6.16  ? 262 PRO B CB  1 
ATOM   3273 C CG  . PRO B 2 262 ? 218.632 258.386 359.505 1.00 9.59  ? 262 PRO B CG  1 
ATOM   3274 C CD  . PRO B 2 262 ? 218.158 259.790 359.617 1.00 4.86  ? 262 PRO B CD  1 
ATOM   3275 N N   . HIS B 2 263 ? 214.321 257.074 360.236 1.00 2.95  ? 263 HIS B N   1 
ATOM   3276 C CA  . HIS B 2 263 ? 213.416 256.621 361.279 1.00 4.19  ? 263 HIS B CA  1 
ATOM   3277 C C   . HIS B 2 263 ? 212.479 255.563 360.723 1.00 1.20  ? 263 HIS B C   1 
ATOM   3278 O O   . HIS B 2 263 ? 212.357 255.376 359.511 1.00 7.80  ? 263 HIS B O   1 
ATOM   3279 C CB  . HIS B 2 263 ? 212.600 257.782 361.849 1.00 0.82  ? 263 HIS B CB  1 
ATOM   3280 C CG  . HIS B 2 263 ? 211.597 258.327 360.885 1.00 8.43  ? 263 HIS B CG  1 
ATOM   3281 N ND1 . HIS B 2 263 ? 211.890 259.344 360.003 1.00 10.42 ? 263 HIS B ND1 1 
ATOM   3282 C CD2 . HIS B 2 263 ? 210.312 257.976 360.640 1.00 5.66  ? 263 HIS B CD2 1 
ATOM   3283 C CE1 . HIS B 2 263 ? 210.825 259.607 359.268 1.00 7.17  ? 263 HIS B CE1 1 
ATOM   3284 N NE2 . HIS B 2 263 ? 209.854 258.790 359.634 1.00 8.63  ? 263 HIS B NE2 1 
ATOM   3285 N N   . GLN B 2 264 ? 211.809 254.882 361.645 1.00 4.92  ? 264 GLN B N   1 
ATOM   3286 C CA  . GLN B 2 264 ? 210.720 253.975 361.325 1.00 3.55  ? 264 GLN B CA  1 
ATOM   3287 C C   . GLN B 2 264 ? 209.744 253.980 362.492 1.00 9.52  ? 264 GLN B C   1 
ATOM   3288 O O   . GLN B 2 264 ? 210.152 254.073 363.651 1.00 13.16 ? 264 GLN B O   1 
ATOM   3289 C CB  . GLN B 2 264 ? 211.234 252.556 361.050 1.00 5.85  ? 264 GLN B CB  1 
ATOM   3290 C CG  . GLN B 2 264 ? 210.155 251.566 360.653 1.00 18.70 ? 264 GLN B CG  1 
ATOM   3291 C CD  . GLN B 2 264 ? 209.450 251.951 359.369 1.00 19.70 ? 264 GLN B CD  1 
ATOM   3292 O OE1 . GLN B 2 264 ? 208.430 252.641 359.390 1.00 21.68 ? 264 GLN B OE1 1 
ATOM   3293 N NE2 . GLN B 2 264 ? 209.990 251.505 358.241 1.00 22.70 ? 264 GLN B NE2 1 
ATOM   3294 N N   . ILE B 2 265 ? 208.458 253.882 362.186 1.00 10.08 ? 265 ILE B N   1 
ATOM   3295 C CA  . ILE B 2 265 ? 207.422 253.800 363.206 1.00 4.50  ? 265 ILE B CA  1 
ATOM   3296 C C   . ILE B 2 265 ? 206.984 252.349 363.340 1.00 5.00  ? 265 ILE B C   1 
ATOM   3297 O O   . ILE B 2 265 ? 206.672 251.687 362.342 1.00 12.49 ? 265 ILE B O   1 
ATOM   3298 C CB  . ILE B 2 265 ? 206.228 254.710 362.869 1.00 5.56  ? 265 ILE B CB  1 
ATOM   3299 C CG1 . ILE B 2 265 ? 206.680 256.174 362.821 1.00 9.39  ? 265 ILE B CG1 1 
ATOM   3300 C CG2 . ILE B 2 265 ? 205.108 254.510 363.891 1.00 11.28 ? 265 ILE B CG2 1 
ATOM   3301 C CD1 . ILE B 2 265 ? 205.570 257.167 362.554 1.00 12.22 ? 265 ILE B CD1 1 
ATOM   3302 N N   . ILE B 2 266 ? 206.976 251.852 364.569 1.00 8.24  ? 266 ILE B N   1 
ATOM   3303 C CA  . ILE B 2 266 ? 206.378 250.567 364.902 1.00 8.82  ? 266 ILE B CA  1 
ATOM   3304 C C   . ILE B 2 266 ? 205.011 250.881 365.496 1.00 4.02  ? 266 ILE B C   1 
ATOM   3305 O O   . ILE B 2 266 ? 204.904 251.284 366.655 1.00 6.31  ? 266 ILE B O   1 
ATOM   3306 C CB  . ILE B 2 266 ? 207.252 249.759 365.864 1.00 5.77  ? 266 ILE B CB  1 
ATOM   3307 C CG1 . ILE B 2 266 ? 208.588 249.420 365.200 1.00 8.71  ? 266 ILE B CG1 1 
ATOM   3308 C CG2 . ILE B 2 266 ? 206.529 248.483 366.299 1.00 11.43 ? 266 ILE B CG2 1 
ATOM   3309 C CD1 . ILE B 2 266 ? 209.559 248.684 366.096 1.00 3.74  ? 266 ILE B CD1 1 
ATOM   3310 N N   . ASN B 2 267 ? 203.968 250.727 364.688 1.00 9.74  ? 267 ASN B N   1 
ATOM   3311 C CA  . ASN B 2 267 ? 202.589 250.920 365.120 1.00 10.29 ? 267 ASN B CA  1 
ATOM   3312 C C   . ASN B 2 267 ? 202.014 249.538 365.400 1.00 8.78  ? 267 ASN B C   1 
ATOM   3313 O O   . ASN B 2 267 ? 201.870 248.724 364.483 1.00 15.89 ? 267 ASN B O   1 
ATOM   3314 C CB  . ASN B 2 267 ? 201.791 251.661 364.048 1.00 11.94 ? 267 ASN B CB  1 
ATOM   3315 C CG  . ASN B 2 267 ? 200.474 252.217 364.565 1.00 9.09  ? 267 ASN B CG  1 
ATOM   3316 O OD1 . ASN B 2 267 ? 200.220 252.243 365.768 1.00 10.00 ? 267 ASN B OD1 1 
ATOM   3317 N ND2 . ASN B 2 267 ? 199.634 252.678 363.648 1.00 7.71  ? 267 ASN B ND2 1 
ATOM   3318 N N   . LEU B 2 268 ? 201.690 249.273 366.668 1.00 6.68  ? 268 LEU B N   1 
ATOM   3319 C CA  . LEU B 2 268 ? 201.349 247.912 367.076 1.00 6.59  ? 268 LEU B CA  1 
ATOM   3320 C C   . LEU B 2 268 ? 200.207 247.334 366.250 1.00 9.36  ? 268 LEU B C   1 
ATOM   3321 O O   . LEU B 2 268 ? 200.159 246.119 366.030 1.00 16.91 ? 268 LEU B O   1 
ATOM   3322 C CB  . LEU B 2 268 ? 200.995 247.882 368.563 1.00 11.85 ? 268 LEU B CB  1 
ATOM   3323 C CG  . LEU B 2 268 ? 202.138 248.188 369.539 1.00 12.17 ? 268 LEU B CG  1 
ATOM   3324 C CD1 . LEU B 2 268 ? 201.669 248.053 370.977 1.00 8.63  ? 268 LEU B CD1 1 
ATOM   3325 C CD2 . LEU B 2 268 ? 203.343 247.295 369.288 1.00 8.49  ? 268 LEU B CD2 1 
ATOM   3326 N N   . ARG B 2 269 ? 199.284 248.173 365.783 1.00 8.34  ? 269 ARG B N   1 
ATOM   3327 C CA  . ARG B 2 269 ? 198.198 247.681 364.947 1.00 13.15 ? 269 ARG B CA  1 
ATOM   3328 C C   . ARG B 2 269 ? 198.653 247.311 363.540 1.00 8.70  ? 269 ARG B C   1 
ATOM   3329 O O   . ARG B 2 269 ? 197.905 246.633 362.831 1.00 17.63 ? 269 ARG B O   1 
ATOM   3330 C CB  . ARG B 2 269 ? 197.084 248.727 364.867 1.00 6.69  ? 269 ARG B CB  1 
ATOM   3331 C CG  . ARG B 2 269 ? 197.385 249.900 363.940 1.00 11.72 ? 269 ARG B CG  1 
ATOM   3332 C CD  . ARG B 2 269 ? 196.378 251.024 364.120 1.00 11.95 ? 269 ARG B CD  1 
ATOM   3333 N NE  . ARG B 2 269 ? 195.003 250.536 364.157 1.00 11.72 ? 269 ARG B NE  1 
ATOM   3334 C CZ  . ARG B 2 269 ? 194.226 250.374 363.094 1.00 10.86 ? 269 ARG B CZ  1 
ATOM   3335 N NH1 . ARG B 2 269 ? 194.650 250.660 361.875 1.00 17.53 ? 269 ARG B NH1 1 
ATOM   3336 N NH2 . ARG B 2 269 ? 192.992 249.908 363.259 1.00 12.39 ? 269 ARG B NH2 1 
ATOM   3337 N N   . THR B 2 270 ? 199.849 247.725 363.122 1.00 11.21 ? 270 THR B N   1 
ATOM   3338 C CA  . THR B 2 270 ? 200.316 247.515 361.756 1.00 9.74  ? 270 THR B CA  1 
ATOM   3339 C C   . THR B 2 270 ? 201.534 246.609 361.676 1.00 5.83  ? 270 THR B C   1 
ATOM   3340 O O   . THR B 2 270 ? 201.571 245.708 360.831 1.00 20.32 ? 270 THR B O   1 
ATOM   3341 C CB  . THR B 2 270 ? 200.634 248.870 361.094 1.00 14.04 ? 270 THR B CB  1 
ATOM   3342 O OG1 . THR B 2 270 ? 199.453 249.681 361.059 1.00 20.03 ? 270 THR B OG1 1 
ATOM   3343 C CG2 . THR B 2 270 ? 201.146 248.676 359.674 1.00 16.61 ? 270 THR B CG2 1 
ATOM   3344 N N   . ASN B 2 271 ? 202.539 246.819 362.522 1.00 12.42 ? 271 ASN B N   1 
ATOM   3345 C CA  . ASN B 2 271 ? 203.785 246.076 362.408 1.00 9.62  ? 271 ASN B CA  1 
ATOM   3346 C C   . ASN B 2 271 ? 204.366 245.836 363.792 1.00 7.27  ? 271 ASN B C   1 
ATOM   3347 O O   . ASN B 2 271 ? 204.017 246.511 364.764 1.00 13.13 ? 271 ASN B O   1 
ATOM   3348 C CB  . ASN B 2 271 ? 204.797 246.809 361.514 1.00 10.93 ? 271 ASN B CB  1 
ATOM   3349 C CG  . ASN B 2 271 ? 205.078 248.226 361.980 1.00 11.42 ? 271 ASN B CG  1 
ATOM   3350 O OD1 . ASN B 2 271 ? 204.183 248.934 362.440 1.00 15.70 ? 271 ASN B OD1 1 
ATOM   3351 N ND2 . ASN B 2 271 ? 206.330 248.647 361.860 1.00 20.03 ? 271 ASN B ND2 1 
ATOM   3352 N N   . ASN B 2 272 ? 205.258 244.850 363.868 1.00 8.16  ? 272 ASN B N   1 
ATOM   3353 C CA  . ASN B 2 272 ? 205.903 244.472 365.119 1.00 13.14 ? 272 ASN B CA  1 
ATOM   3354 C C   . ASN B 2 272 ? 207.417 244.625 365.064 1.00 14.23 ? 272 ASN B C   1 
ATOM   3355 O O   . ASN B 2 272 ? 208.104 244.207 366.002 1.00 17.66 ? 272 ASN B O   1 
ATOM   3356 C CB  . ASN B 2 272 ? 205.538 243.028 365.485 1.00 9.90  ? 272 ASN B CB  1 
ATOM   3357 C CG  . ASN B 2 272 ? 205.962 242.026 364.424 1.00 13.29 ? 272 ASN B CG  1 
ATOM   3358 O OD1 . ASN B 2 272 ? 206.902 242.259 363.666 1.00 17.66 ? 272 ASN B OD1 1 
ATOM   3359 N ND2 . ASN B 2 272 ? 205.267 240.898 364.370 1.00 17.19 ? 272 ASN B ND2 1 
ATOM   3360 N N   . CYS B 2 273 ? 207.957 245.202 363.994 1.00 10.70 ? 273 CYS B N   1 
ATOM   3361 C CA  . CYS B 2 273 ? 209.399 245.328 363.861 1.00 12.62 ? 273 CYS B CA  1 
ATOM   3362 C C   . CYS B 2 273 ? 209.734 246.538 363.004 1.00 8.00  ? 273 CYS B C   1 
ATOM   3363 O O   . CYS B 2 273 ? 208.932 246.992 362.185 1.00 20.93 ? 273 CYS B O   1 
ATOM   3364 C CB  . CYS B 2 273 ? 210.020 244.064 363.254 1.00 14.78 ? 273 CYS B CB  1 
ATOM   3365 S SG  . CYS B 2 273 ? 209.589 243.784 361.523 1.00 34.83 ? 273 CYS B SG  1 
ATOM   3366 N N   . ALA B 2 274 ? 210.941 247.053 363.214 1.00 8.70  ? 274 ALA B N   1 
ATOM   3367 C CA  . ALA B 2 274 ? 211.507 248.129 362.414 1.00 8.14  ? 274 ALA B CA  1 
ATOM   3368 C C   . ALA B 2 274 ? 212.933 247.768 362.030 1.00 7.90  ? 274 ALA B C   1 
ATOM   3369 O O   . ALA B 2 274 ? 213.708 247.306 362.868 1.00 7.17  ? 274 ALA B O   1 
ATOM   3370 C CB  . ALA B 2 274 ? 211.496 249.461 363.170 1.00 9.09  ? 274 ALA B CB  1 
ATOM   3371 N N   . THR B 2 275 ? 213.280 247.984 360.766 1.00 6.61  ? 275 THR B N   1 
ATOM   3372 C CA  . THR B 2 275 ? 214.622 247.710 360.268 1.00 5.58  ? 275 THR B CA  1 
ATOM   3373 C C   . THR B 2 275 ? 215.202 248.991 359.690 1.00 7.50  ? 275 THR B C   1 
ATOM   3374 O O   . THR B 2 275 ? 214.634 249.574 358.761 1.00 14.25 ? 275 THR B O   1 
ATOM   3375 C CB  . THR B 2 275 ? 214.611 246.598 359.215 1.00 11.34 ? 275 THR B CB  1 
ATOM   3376 O OG1 . THR B 2 275 ? 214.082 245.399 359.790 1.00 15.65 ? 275 THR B OG1 1 
ATOM   3377 C CG2 . THR B 2 275 ? 216.020 246.329 358.703 1.00 11.13 ? 275 THR B CG2 1 
ATOM   3378 N N   . LEU B 2 276 ? 216.326 249.425 360.245 1.00 4.31  ? 276 LEU B N   1 
ATOM   3379 C CA  . LEU B 2 276 ? 217.042 250.600 359.776 1.00 6.31  ? 276 LEU B CA  1 
ATOM   3380 C C   . LEU B 2 276 ? 218.435 250.179 359.335 1.00 7.45  ? 276 LEU B C   1 
ATOM   3381 O O   . LEU B 2 276 ? 219.177 249.573 360.111 1.00 11.60 ? 276 LEU B O   1 
ATOM   3382 C CB  . LEU B 2 276 ? 217.128 251.669 360.870 1.00 4.69  ? 276 LEU B CB  1 
ATOM   3383 C CG  . LEU B 2 276 ? 215.812 252.189 361.461 1.00 11.97 ? 276 LEU B CG  1 
ATOM   3384 C CD1 . LEU B 2 276 ? 215.125 251.134 362.323 1.00 16.03 ? 276 LEU B CD1 1 
ATOM   3385 C CD2 . LEU B 2 276 ? 216.051 253.455 362.265 1.00 12.00 ? 276 LEU B CD2 1 
ATOM   3386 N N   . VAL B 2 277 ? 218.786 250.494 358.096 1.00 11.95 ? 277 VAL B N   1 
ATOM   3387 C CA  . VAL B 2 277 ? 220.120 250.230 357.570 1.00 7.29  ? 277 VAL B CA  1 
ATOM   3388 C C   . VAL B 2 277 ? 220.869 251.555 357.578 1.00 9.28  ? 277 VAL B C   1 
ATOM   3389 O O   . VAL B 2 277 ? 220.508 252.491 356.859 1.00 9.05  ? 277 VAL B O   1 
ATOM   3390 C CB  . VAL B 2 277 ? 220.070 249.615 356.166 1.00 6.93  ? 277 VAL B CB  1 
ATOM   3391 C CG1 . VAL B 2 277 ? 221.477 249.306 355.670 1.00 8.44  ? 277 VAL B CG1 1 
ATOM   3392 C CG2 . VAL B 2 277 ? 219.206 248.357 356.162 1.00 8.09  ? 277 VAL B CG2 1 
ATOM   3393 N N   . LEU B 2 278 ? 221.913 251.636 358.395 1.00 4.56  ? 278 LEU B N   1 
ATOM   3394 C CA  . LEU B 2 278 ? 222.660 252.862 358.606 1.00 4.77  ? 278 LEU B CA  1 
ATOM   3395 C C   . LEU B 2 278 ? 224.022 252.745 357.944 1.00 3.21  ? 278 LEU B C   1 
ATOM   3396 O O   . LEU B 2 278 ? 224.808 251.872 358.338 1.00 6.80  ? 278 LEU B O   1 
ATOM   3397 C CB  . LEU B 2 278 ? 222.821 253.134 360.099 1.00 5.04  ? 278 LEU B CB  1 
ATOM   3398 C CG  . LEU B 2 278 ? 221.561 252.961 360.948 1.00 8.19  ? 278 LEU B CG  1 
ATOM   3399 C CD1 . LEU B 2 278 ? 221.869 253.205 362.419 1.00 2.24  ? 278 LEU B CD1 1 
ATOM   3400 C CD2 . LEU B 2 278 ? 220.451 253.878 360.460 1.00 4.56  ? 278 LEU B CD2 1 
ATOM   3401 N N   . PRO B 2 279 ? 224.356 253.565 356.954 1.00 4.74  ? 279 PRO B N   1 
ATOM   3402 C CA  . PRO B 2 279 ? 225.743 253.609 356.492 1.00 4.48  ? 279 PRO B CA  1 
ATOM   3403 C C   . PRO B 2 279 ? 226.620 254.262 357.546 1.00 0.71  ? 279 PRO B C   1 
ATOM   3404 O O   . PRO B 2 279 ? 226.142 254.925 358.468 1.00 2.82  ? 279 PRO B O   1 
ATOM   3405 C CB  . PRO B 2 279 ? 225.669 254.455 355.219 1.00 5.05  ? 279 PRO B CB  1 
ATOM   3406 C CG  . PRO B 2 279 ? 224.528 255.374 355.466 1.00 2.63  ? 279 PRO B CG  1 
ATOM   3407 C CD  . PRO B 2 279 ? 223.530 254.592 356.292 1.00 4.10  ? 279 PRO B CD  1 
ATOM   3408 N N   . TYR B 2 280 ? 227.923 254.051 357.415 1.00 4.95  ? 280 TYR B N   1 
ATOM   3409 C CA  . TYR B 2 280 ? 228.860 254.785 358.253 1.00 6.86  ? 280 TYR B CA  1 
ATOM   3410 C C   . TYR B 2 280 ? 228.775 256.268 357.920 1.00 0.01  ? 280 TYR B C   1 
ATOM   3411 O O   . TYR B 2 280 ? 229.062 256.678 356.793 1.00 11.09 ? 280 TYR B O   1 
ATOM   3412 C CB  . TYR B 2 280 ? 230.281 254.269 358.050 1.00 4.43  ? 280 TYR B CB  1 
ATOM   3413 C CG  . TYR B 2 280 ? 231.313 255.002 358.876 1.00 9.48  ? 280 TYR B CG  1 
ATOM   3414 C CD1 . TYR B 2 280 ? 231.498 254.702 360.220 1.00 1.67  ? 280 TYR B CD1 1 
ATOM   3415 C CD2 . TYR B 2 280 ? 232.107 255.991 358.311 1.00 2.70  ? 280 TYR B CD2 1 
ATOM   3416 C CE1 . TYR B 2 280 ? 232.442 255.367 360.976 1.00 7.08  ? 280 TYR B CE1 1 
ATOM   3417 C CE2 . TYR B 2 280 ? 233.056 256.657 359.057 1.00 3.11  ? 280 TYR B CE2 1 
ATOM   3418 C CZ  . TYR B 2 280 ? 233.220 256.343 360.388 1.00 7.24  ? 280 TYR B CZ  1 
ATOM   3419 O OH  . TYR B 2 280 ? 234.161 257.007 361.133 1.00 12.07 ? 280 TYR B OH  1 
ATOM   3420 N N   . VAL B 2 281 ? 228.361 257.067 358.896 1.00 4.97  ? 281 VAL B N   1 
ATOM   3421 C CA  . VAL B 2 281 ? 228.211 258.507 358.735 1.00 4.11  ? 281 VAL B CA  1 
ATOM   3422 C C   . VAL B 2 281 ? 229.183 259.184 359.688 1.00 8.02  ? 281 VAL B C   1 
ATOM   3423 O O   . VAL B 2 281 ? 229.128 258.960 360.903 1.00 18.28 ? 281 VAL B O   1 
ATOM   3424 C CB  . VAL B 2 281 ? 226.767 258.965 358.998 1.00 5.63  ? 281 VAL B CB  1 
ATOM   3425 C CG1 . VAL B 2 281 ? 226.681 260.483 358.985 1.00 6.63  ? 281 VAL B CG1 1 
ATOM   3426 C CG2 . VAL B 2 281 ? 225.823 258.362 357.965 1.00 10.03 ? 281 VAL B CG2 1 
ATOM   3427 N N   . ASN B 2 282 ? 230.066 260.009 359.135 1.00 6.84  ? 282 ASN B N   1 
ATOM   3428 C CA  . ASN B 2 282 ? 231.065 260.736 359.906 1.00 5.83  ? 282 ASN B CA  1 
ATOM   3429 C C   . ASN B 2 282 ? 231.702 261.762 358.980 1.00 3.67  ? 282 ASN B C   1 
ATOM   3430 O O   . ASN B 2 282 ? 231.570 261.678 357.756 1.00 8.31  ? 282 ASN B O   1 
ATOM   3431 C CB  . ASN B 2 282 ? 232.127 259.790 360.488 1.00 4.88  ? 282 ASN B CB  1 
ATOM   3432 C CG  . ASN B 2 282 ? 232.937 260.430 361.600 1.00 3.67  ? 282 ASN B CG  1 
ATOM   3433 O OD1 . ASN B 2 282 ? 232.700 261.576 361.978 1.00 18.81 ? 282 ASN B OD1 1 
ATOM   3434 N ND2 . ASN B 2 282 ? 233.888 259.685 362.137 1.00 10.80 ? 282 ASN B ND2 1 
ATOM   3435 N N   . SER B 2 283 ? 232.400 262.725 359.576 1.00 4.98  ? 283 SER B N   1 
ATOM   3436 C CA  . SER B 2 283 ? 233.172 263.689 358.800 1.00 9.92  ? 283 SER B CA  1 
ATOM   3437 C C   . SER B 2 283 ? 234.530 263.142 358.377 1.00 6.98  ? 283 SER B C   1 
ATOM   3438 O O   . SER B 2 283 ? 235.296 263.861 357.730 1.00 12.21 ? 283 SER B O   1 
ATOM   3439 C CB  . SER B 2 283 ? 233.360 264.984 359.595 1.00 3.75  ? 283 SER B CB  1 
ATOM   3440 O OG  . SER B 2 283 ? 234.060 264.757 360.801 1.00 10.15 ? 283 SER B OG  1 
ATOM   3441 N N   . LEU B 2 284 ? 234.837 261.897 358.729 1.00 6.93  ? 284 LEU B N   1 
ATOM   3442 C CA  . LEU B 2 284 ? 236.072 261.233 358.348 1.00 9.21  ? 284 LEU B CA  1 
ATOM   3443 C C   . LEU B 2 284 ? 235.734 259.885 357.730 1.00 9.25  ? 284 LEU B C   1 
ATOM   3444 O O   . LEU B 2 284 ? 234.669 259.317 357.979 1.00 17.68 ? 284 LEU B O   1 
ATOM   3445 C CB  . LEU B 2 284 ? 236.994 261.039 359.556 1.00 9.94  ? 284 LEU B CB  1 
ATOM   3446 C CG  . LEU B 2 284 ? 237.380 262.312 360.306 1.00 11.26 ? 284 LEU B CG  1 
ATOM   3447 C CD1 . LEU B 2 284 ? 237.860 261.983 361.710 1.00 12.53 ? 284 LEU B CD1 1 
ATOM   3448 C CD2 . LEU B 2 284 ? 238.444 263.074 359.534 1.00 10.40 ? 284 LEU B CD2 1 
ATOM   3449 N N   . SER B 2 285 ? 236.654 259.376 356.911 1.00 7.13  ? 285 SER B N   1 
ATOM   3450 C CA  . SER B 2 285 ? 236.476 258.039 356.356 1.00 12.42 ? 285 SER B CA  1 
ATOM   3451 C C   . SER B 2 285 ? 236.469 256.985 357.456 1.00 9.02  ? 285 SER B C   1 
ATOM   3452 O O   . SER B 2 285 ? 235.720 256.006 357.383 1.00 15.75 ? 285 SER B O   1 
ATOM   3453 C CB  . SER B 2 285 ? 237.570 257.739 355.334 1.00 14.52 ? 285 SER B CB  1 
ATOM   3454 O OG  . SER B 2 285 ? 237.315 258.409 354.115 1.00 25.54 ? 285 SER B OG  1 
ATOM   3455 N N   . ILE B 2 286 ? 237.298 257.167 358.481 1.00 7.61  ? 286 ILE B N   1 
ATOM   3456 C CA  . ILE B 2 286 ? 237.373 256.229 359.592 1.00 8.10  ? 286 ILE B CA  1 
ATOM   3457 C C   . ILE B 2 286 ? 237.791 257.003 360.832 1.00 6.20  ? 286 ILE B C   1 
ATOM   3458 O O   . ILE B 2 286 ? 238.455 258.037 360.743 1.00 18.78 ? 286 ILE B O   1 
ATOM   3459 C CB  . ILE B 2 286 ? 238.347 255.065 359.288 1.00 11.60 ? 286 ILE B CB  1 
ATOM   3460 C CG1 . ILE B 2 286 ? 238.241 253.987 360.369 1.00 5.48  ? 286 ILE B CG1 1 
ATOM   3461 C CG2 . ILE B 2 286 ? 239.776 255.580 359.167 1.00 8.63  ? 286 ILE B CG2 1 
ATOM   3462 C CD1 . ILE B 2 286 ? 238.910 252.688 360.002 1.00 14.46 ? 286 ILE B CD1 1 
ATOM   3463 N N   . ASP B 2 287 ? 237.392 256.501 361.995 1.00 5.00  ? 287 ASP B N   1 
ATOM   3464 C CA  . ASP B 2 287 ? 237.599 257.221 363.241 1.00 9.80  ? 287 ASP B CA  1 
ATOM   3465 C C   . ASP B 2 287 ? 237.857 256.214 364.355 1.00 3.81  ? 287 ASP B C   1 
ATOM   3466 O O   . ASP B 2 287 ? 237.854 255.001 364.138 1.00 17.02 ? 287 ASP B O   1 
ATOM   3467 C CB  . ASP B 2 287 ? 236.390 258.112 363.547 1.00 9.78  ? 287 ASP B CB  1 
ATOM   3468 C CG  . ASP B 2 287 ? 236.736 259.292 364.430 1.00 7.91  ? 287 ASP B CG  1 
ATOM   3469 O OD1 . ASP B 2 287 ? 237.761 259.235 365.138 1.00 20.17 ? 287 ASP B OD1 1 
ATOM   3470 O OD2 . ASP B 2 287 ? 235.972 260.278 364.423 1.00 18.84 ? 287 ASP B OD2 1 
ATOM   3471 N N   . SER B 2 288 ? 238.088 256.732 365.556 1.00 4.78  ? 288 SER B N   1 
ATOM   3472 C CA  . SER B 2 288 ? 238.256 255.895 366.737 1.00 11.15 ? 288 SER B CA  1 
ATOM   3473 C C   . SER B 2 288 ? 236.887 255.476 367.263 1.00 11.82 ? 288 SER B C   1 
ATOM   3474 O O   . SER B 2 288 ? 236.077 256.324 367.650 1.00 16.45 ? 288 SER B O   1 
ATOM   3475 C CB  . SER B 2 288 ? 239.040 256.647 367.809 1.00 10.78 ? 288 SER B CB  1 
ATOM   3476 O OG  . SER B 2 288 ? 239.015 255.953 369.041 1.00 20.32 ? 288 SER B OG  1 
ATOM   3477 N N   . MET B 2 289 ? 236.634 254.167 367.280 1.00 14.32 ? 289 MET B N   1 
ATOM   3478 C CA  . MET B 2 289 ? 235.348 253.669 367.758 1.00 10.43 ? 289 MET B CA  1 
ATOM   3479 C C   . MET B 2 289 ? 235.175 253.914 369.251 1.00 10.75 ? 289 MET B C   1 
ATOM   3480 O O   . MET B 2 289 ? 234.058 254.166 369.716 1.00 17.05 ? 289 MET B O   1 
ATOM   3481 C CB  . MET B 2 289 ? 235.213 252.179 367.447 1.00 9.68  ? 289 MET B CB  1 
ATOM   3482 C CG  . MET B 2 289 ? 234.827 251.877 366.012 1.00 12.62 ? 289 MET B CG  1 
ATOM   3483 S SD  . MET B 2 289 ? 234.355 250.152 365.787 1.00 31.29 ? 289 MET B SD  1 
ATOM   3484 C CE  . MET B 2 289 ? 233.587 250.216 364.173 1.00 14.49 ? 289 MET B CE  1 
ATOM   3485 N N   . THR B 2 290 ? 236.261 253.831 370.021 1.00 7.72  ? 290 THR B N   1 
ATOM   3486 C CA  . THR B 2 290 ? 236.148 253.998 371.465 1.00 13.16 ? 290 THR B CA  1 
ATOM   3487 C C   . THR B 2 290 ? 235.932 255.459 371.841 1.00 8.71  ? 290 THR B C   1 
ATOM   3488 O O   . THR B 2 290 ? 235.211 255.756 372.799 1.00 16.47 ? 290 THR B O   1 
ATOM   3489 C CB  . THR B 2 290 ? 237.394 253.442 372.158 1.00 11.96 ? 290 THR B CB  1 
ATOM   3490 O OG1 . THR B 2 290 ? 238.563 254.086 371.642 1.00 16.10 ? 290 THR B OG1 1 
ATOM   3491 C CG2 . THR B 2 290 ? 237.504 251.939 371.933 1.00 11.55 ? 290 THR B CG2 1 
ATOM   3492 N N   . LYS B 2 291 ? 236.550 256.385 371.106 1.00 7.12  ? 291 LYS B N   1 
ATOM   3493 C CA  . LYS B 2 291 ? 236.369 257.802 371.408 1.00 16.29 ? 291 LYS B CA  1 
ATOM   3494 C C   . LYS B 2 291 ? 234.999 258.297 370.962 1.00 10.36 ? 291 LYS B C   1 
ATOM   3495 O O   . LYS B 2 291 ? 234.376 259.113 371.649 1.00 12.64 ? 291 LYS B O   1 
ATOM   3496 C CB  . LYS B 2 291 ? 237.462 258.632 370.732 1.00 7.65  ? 291 LYS B CB  1 
ATOM   3497 C CG  . LYS B 2 291 ? 238.831 258.513 371.368 1.00 15.66 ? 291 LYS B CG  1 
ATOM   3498 C CD  . LYS B 2 291 ? 239.864 259.345 370.631 1.00 14.05 ? 291 LYS B CD  1 
ATOM   3499 C CE  . LYS B 2 291 ? 241.216 259.284 371.319 1.00 13.65 ? 291 LYS B CE  1 
ATOM   3500 N NZ  . LYS B 2 291 ? 242.214 260.168 370.663 1.00 15.63 ? 291 LYS B NZ  1 
ATOM   3501 N N   . HIS B 2 292 ? 234.516 257.811 369.823 1.00 7.53  ? 292 HIS B N   1 
ATOM   3502 C CA  . HIS B 2 292 ? 233.451 258.464 369.077 1.00 13.73 ? 292 HIS B CA  1 
ATOM   3503 C C   . HIS B 2 292 ? 232.340 257.474 368.761 1.00 5.92  ? 292 HIS B C   1 
ATOM   3504 O O   . HIS B 2 292 ? 232.603 256.385 368.242 1.00 10.54 ? 292 HIS B O   1 
ATOM   3505 C CB  . HIS B 2 292 ? 234.013 259.062 367.782 1.00 8.71  ? 292 HIS B CB  1 
ATOM   3506 C CG  . HIS B 2 292 ? 233.034 259.898 367.023 1.00 8.71  ? 292 HIS B CG  1 
ATOM   3507 N ND1 . HIS B 2 292 ? 233.174 260.170 365.679 1.00 12.26 ? 292 HIS B ND1 1 
ATOM   3508 C CD2 . HIS B 2 292 ? 231.906 260.533 367.419 1.00 10.67 ? 292 HIS B CD2 1 
ATOM   3509 C CE1 . HIS B 2 292 ? 232.172 260.930 365.279 1.00 4.84  ? 292 HIS B CE1 1 
ATOM   3510 N NE2 . HIS B 2 292 ? 231.388 261.164 366.316 1.00 15.24 ? 292 HIS B NE2 1 
ATOM   3511 N N   . ASN B 2 293 ? 231.104 257.857 369.067 1.00 9.68  ? 293 ASN B N   1 
ATOM   3512 C CA  . ASN B 2 293 ? 229.920 257.091 368.690 1.00 4.38  ? 293 ASN B CA  1 
ATOM   3513 C C   . ASN B 2 293 ? 229.320 257.724 367.442 1.00 3.98  ? 293 ASN B C   1 
ATOM   3514 O O   . ASN B 2 293 ? 228.848 258.863 367.481 1.00 16.60 ? 293 ASN B O   1 
ATOM   3515 C CB  . ASN B 2 293 ? 228.905 257.052 369.828 1.00 4.03  ? 293 ASN B CB  1 
ATOM   3516 C CG  . ASN B 2 293 ? 229.274 256.051 370.897 1.00 6.50  ? 293 ASN B CG  1 
ATOM   3517 O OD1 . ASN B 2 293 ? 229.633 254.914 370.599 1.00 13.46 ? 293 ASN B OD1 1 
ATOM   3518 N ND2 . ASN B 2 293 ? 229.198 256.470 372.150 1.00 9.84  ? 293 ASN B ND2 1 
ATOM   3519 N N   . ASN B 2 294 ? 229.339 256.980 366.336 1.00 8.31  ? 294 ASN B N   1 
ATOM   3520 C CA  . ASN B 2 294 ? 228.856 257.528 365.075 1.00 7.80  ? 294 ASN B CA  1 
ATOM   3521 C C   . ASN B 2 294 ? 227.339 257.639 365.052 1.00 8.65  ? 294 ASN B C   1 
ATOM   3522 O O   . ASN B 2 294 ? 226.802 258.576 364.452 1.00 8.16  ? 294 ASN B O   1 
ATOM   3523 C CB  . ASN B 2 294 ? 229.336 256.669 363.905 1.00 0.01  ? 294 ASN B CB  1 
ATOM   3524 C CG  . ASN B 2 294 ? 230.824 256.403 363.954 1.00 13.52 ? 294 ASN B CG  1 
ATOM   3525 O OD1 . ASN B 2 294 ? 231.259 255.332 364.370 1.00 17.71 ? 294 ASN B OD1 1 
ATOM   3526 N ND2 . ASN B 2 294 ? 231.616 257.386 363.540 1.00 17.46 ? 294 ASN B ND2 1 
ATOM   3527 N N   . TRP B 2 295 ? 226.631 256.708 365.686 1.00 10.96 ? 295 TRP B N   1 
ATOM   3528 C CA  . TRP B 2 295 ? 225.178 256.698 365.607 1.00 1.21  ? 295 TRP B CA  1 
ATOM   3529 C C   . TRP B 2 295 ? 224.570 256.636 366.996 1.00 0.01  ? 295 TRP B C   1 
ATOM   3530 O O   . TRP B 2 295 ? 225.154 256.087 367.927 1.00 15.50 ? 295 TRP B O   1 
ATOM   3531 C CB  . TRP B 2 295 ? 224.665 255.520 364.775 1.00 6.64  ? 295 TRP B CB  1 
ATOM   3532 C CG  . TRP B 2 295 ? 224.763 255.723 363.298 1.00 1.23  ? 295 TRP B CG  1 
ATOM   3533 C CD1 . TRP B 2 295 ? 225.741 255.259 362.472 1.00 3.43  ? 295 TRP B CD1 1 
ATOM   3534 C CD2 . TRP B 2 295 ? 223.841 256.438 362.467 1.00 2.98  ? 295 TRP B CD2 1 
ATOM   3535 N NE1 . TRP B 2 295 ? 225.487 255.638 361.178 1.00 7.71  ? 295 TRP B NE1 1 
ATOM   3536 C CE2 . TRP B 2 295 ? 224.327 256.365 361.148 1.00 1.97  ? 295 TRP B CE2 1 
ATOM   3537 C CE3 . TRP B 2 295 ? 222.651 257.132 362.710 1.00 3.76  ? 295 TRP B CE3 1 
ATOM   3538 C CZ2 . TRP B 2 295 ? 223.666 256.956 360.077 1.00 3.53  ? 295 TRP B CZ2 1 
ATOM   3539 C CZ3 . TRP B 2 295 ? 222.000 257.720 361.647 1.00 2.88  ? 295 TRP B CZ3 1 
ATOM   3540 C CH2 . TRP B 2 295 ? 222.506 257.628 360.346 1.00 5.47  ? 295 TRP B CH2 1 
ATOM   3541 N N   . GLY B 2 296 ? 223.398 257.226 367.126 1.00 4.86  ? 296 GLY B N   1 
ATOM   3542 C CA  . GLY B 2 296 ? 222.549 257.023 368.285 1.00 6.47  ? 296 GLY B CA  1 
ATOM   3543 C C   . GLY B 2 296 ? 221.244 256.405 367.828 1.00 0.46  ? 296 GLY B C   1 
ATOM   3544 O O   . GLY B 2 296 ? 220.770 256.687 366.731 1.00 7.34  ? 296 GLY B O   1 
ATOM   3545 N N   . ILE B 2 297 ? 220.689 255.538 368.659 1.00 8.44  ? 297 ILE B N   1 
ATOM   3546 C CA  . ILE B 2 297 ? 219.378 254.949 368.431 1.00 4.28  ? 297 ILE B CA  1 
ATOM   3547 C C   . ILE B 2 297 ? 218.476 255.450 369.542 1.00 2.51  ? 297 ILE B C   1 
ATOM   3548 O O   . ILE B 2 297 ? 218.763 255.231 370.722 1.00 10.64 ? 297 ILE B O   1 
ATOM   3549 C CB  . ILE B 2 297 ? 219.433 253.415 368.415 1.00 4.92  ? 297 ILE B CB  1 
ATOM   3550 C CG1 . ILE B 2 297 ? 220.455 252.914 367.387 1.00 6.05  ? 297 ILE B CG1 1 
ATOM   3551 C CG2 . ILE B 2 297 ? 218.055 252.843 368.132 1.00 2.99  ? 297 ILE B CG2 1 
ATOM   3552 C CD1 . ILE B 2 297 ? 220.084 253.191 365.950 1.00 6.61  ? 297 ILE B CD1 1 
ATOM   3553 N N   . ALA B 2 298 ? 217.400 256.133 369.175 1.00 3.50  ? 298 ALA B N   1 
ATOM   3554 C CA  . ALA B 2 298 ? 216.426 256.629 370.136 1.00 6.10  ? 298 ALA B CA  1 
ATOM   3555 C C   . ALA B 2 298 ? 215.075 256.003 369.832 1.00 0.22  ? 298 ALA B C   1 
ATOM   3556 O O   . ALA B 2 298 ? 214.591 256.083 368.701 1.00 5.45  ? 298 ALA B O   1 
ATOM   3557 C CB  . ALA B 2 298 ? 216.339 258.154 370.093 1.00 4.15  ? 298 ALA B CB  1 
ATOM   3558 N N   . ILE B 2 299 ? 214.474 255.379 370.835 1.00 0.01  ? 299 ILE B N   1 
ATOM   3559 C CA  . ILE B 2 299 ? 213.158 254.771 370.708 1.00 3.47  ? 299 ILE B CA  1 
ATOM   3560 C C   . ILE B 2 299 ? 212.241 255.522 371.659 1.00 1.43  ? 299 ILE B C   1 
ATOM   3561 O O   . ILE B 2 299 ? 212.413 255.455 372.880 1.00 10.35 ? 299 ILE B O   1 
ATOM   3562 C CB  . ILE B 2 299 ? 213.182 253.266 371.010 1.00 3.86  ? 299 ILE B CB  1 
ATOM   3563 C CG1 . ILE B 2 299 ? 214.093 252.554 370.002 1.00 7.39  ? 299 ILE B CG1 1 
ATOM   3564 C CG2 . ILE B 2 299 ? 211.766 252.689 370.987 1.00 8.43  ? 299 ILE B CG2 1 
ATOM   3565 C CD1 . ILE B 2 299 ? 214.210 251.061 370.195 1.00 3.32  ? 299 ILE B CD1 1 
ATOM   3566 N N   . LEU B 2 300 ? 211.283 256.243 371.104 1.00 6.12  ? 300 LEU B N   1 
ATOM   3567 C CA  . LEU B 2 300 ? 210.359 257.022 371.908 1.00 6.69  ? 300 LEU B CA  1 
ATOM   3568 C C   . LEU B 2 300 ? 208.940 256.490 371.762 1.00 6.81  ? 300 LEU B C   1 
ATOM   3569 O O   . LEU B 2 300 ? 208.521 256.157 370.651 1.00 8.38  ? 300 LEU B O   1 
ATOM   3570 C CB  . LEU B 2 300 ? 210.380 258.499 371.499 1.00 7.76  ? 300 LEU B CB  1 
ATOM   3571 C CG  . LEU B 2 300 ? 211.659 259.272 371.813 1.00 11.50 ? 300 LEU B CG  1 
ATOM   3572 C CD1 . LEU B 2 300 ? 211.632 260.629 371.131 1.00 14.69 ? 300 LEU B CD1 1 
ATOM   3573 C CD2 . LEU B 2 300 ? 211.834 259.429 373.314 1.00 9.58  ? 300 LEU B CD2 1 
ATOM   3574 N N   . PRO B 2 301 ? 208.168 256.398 372.845 1.00 7.39  ? 301 PRO B N   1 
ATOM   3575 C CA  . PRO B 2 301 ? 206.747 256.070 372.679 1.00 10.53 ? 301 PRO B CA  1 
ATOM   3576 C C   . PRO B 2 301 ? 205.977 257.251 372.108 1.00 5.60  ? 301 PRO B C   1 
ATOM   3577 O O   . PRO B 2 301 ? 205.688 258.217 372.819 1.00 20.17 ? 301 PRO B O   1 
ATOM   3578 C CB  . PRO B 2 301 ? 206.287 255.721 374.103 1.00 9.69  ? 301 PRO B CB  1 
ATOM   3579 C CG  . PRO B 2 301 ? 207.537 255.589 374.915 1.00 14.63 ? 301 PRO B CG  1 
ATOM   3580 C CD  . PRO B 2 301 ? 208.548 256.461 374.264 1.00 8.80  ? 301 PRO B CD  1 
ATOM   3581 N N   . LEU B 2 302 ? 205.657 257.188 370.817 1.00 7.97  ? 302 LEU B N   1 
ATOM   3582 C CA  . LEU B 2 302 ? 204.838 258.229 370.209 1.00 12.60 ? 302 LEU B CA  1 
ATOM   3583 C C   . LEU B 2 302 ? 203.394 258.125 370.681 1.00 7.39  ? 302 LEU B C   1 
ATOM   3584 O O   . LEU B 2 302 ? 202.727 259.142 370.892 1.00 15.82 ? 302 LEU B O   1 
ATOM   3585 C CB  . LEU B 2 302 ? 204.920 258.131 368.686 1.00 7.88  ? 302 LEU B CB  1 
ATOM   3586 C CG  . LEU B 2 302 ? 206.330 258.212 368.092 1.00 11.41 ? 302 LEU B CG  1 
ATOM   3587 C CD1 . LEU B 2 302 ? 206.291 258.027 366.586 1.00 10.06 ? 302 LEU B CD1 1 
ATOM   3588 C CD2 . LEU B 2 302 ? 206.997 259.531 368.452 1.00 7.95  ? 302 LEU B CD2 1 
ATOM   3589 N N   . ALA B 2 303 ? 202.898 256.901 370.847 1.00 10.24 ? 303 ALA B N   1 
ATOM   3590 C CA  . ALA B 2 303 ? 201.578 256.649 371.411 1.00 7.13  ? 303 ALA B CA  1 
ATOM   3591 C C   . ALA B 2 303 ? 201.775 255.696 372.582 1.00 6.97  ? 303 ALA B C   1 
ATOM   3592 O O   . ALA B 2 303 ? 202.359 254.610 372.396 1.00 16.67 ? 303 ALA B O   1 
ATOM   3593 C CB  . ALA B 2 303 ? 200.626 256.062 370.367 1.00 6.26  ? 303 ALA B CB  1 
ATOM   3594 N N   . PRO B 2 304 ? 201.339 256.045 373.790 1.00 9.64  ? 304 PRO B N   1 
ATOM   3595 C CA  . PRO B 2 304 ? 201.617 255.178 374.942 1.00 13.83 ? 304 PRO B CA  1 
ATOM   3596 C C   . PRO B 2 304 ? 201.012 253.794 374.766 1.00 4.10  ? 304 PRO B C   1 
ATOM   3597 O O   . PRO B 2 304 ? 199.939 253.630 374.184 1.00 13.06 ? 304 PRO B O   1 
ATOM   3598 C CB  . PRO B 2 304 ? 200.978 255.929 376.115 1.00 12.93 ? 304 PRO B CB  1 
ATOM   3599 C CG  . PRO B 2 304 ? 199.969 256.823 375.496 1.00 12.32 ? 304 PRO B CG  1 
ATOM   3600 C CD  . PRO B 2 304 ? 200.533 257.216 374.171 1.00 11.68 ? 304 PRO B CD  1 
ATOM   3601 N N   . LEU B 2 305 ? 201.724 252.792 375.273 1.00 13.07 ? 305 LEU B N   1 
ATOM   3602 C CA  . LEU B 2 305 ? 201.201 251.435 375.282 1.00 12.88 ? 305 LEU B CA  1 
ATOM   3603 C C   . LEU B 2 305 ? 199.918 251.377 376.099 1.00 6.05  ? 305 LEU B C   1 
ATOM   3604 O O   . LEU B 2 305 ? 199.822 251.966 377.177 1.00 14.78 ? 305 LEU B O   1 
ATOM   3605 C CB  . LEU B 2 305 ? 202.234 250.471 375.866 1.00 8.94  ? 305 LEU B CB  1 
ATOM   3606 C CG  . LEU B 2 305 ? 201.820 249.000 375.969 1.00 13.80 ? 305 LEU B CG  1 
ATOM   3607 C CD1 . LEU B 2 305 ? 201.690 248.378 374.590 1.00 11.66 ? 305 LEU B CD1 1 
ATOM   3608 C CD2 . LEU B 2 305 ? 202.813 248.224 376.820 1.00 10.14 ? 305 LEU B CD2 1 
ATOM   3609 N N   . ASP B 2 306 ? 198.927 250.660 375.580 1.00 8.05  ? 306 ASP B N   1 
ATOM   3610 C CA  . ASP B 2 306 ? 197.685 250.469 376.310 1.00 14.75 ? 306 ASP B CA  1 
ATOM   3611 C C   . ASP B 2 306 ? 197.110 249.102 375.978 1.00 9.93  ? 306 ASP B C   1 
ATOM   3612 O O   . ASP B 2 306 ? 197.346 248.554 374.899 1.00 9.39  ? 306 ASP B O   1 
ATOM   3613 C CB  . ASP B 2 306 ? 196.665 251.567 375.990 1.00 6.57  ? 306 ASP B CB  1 
ATOM   3614 C CG  . ASP B 2 306 ? 195.522 251.606 376.982 1.00 18.74 ? 306 ASP B CG  1 
ATOM   3615 O OD1 . ASP B 2 306 ? 195.531 250.808 377.941 1.00 21.81 ? 306 ASP B OD1 1 
ATOM   3616 O OD2 . ASP B 2 306 ? 194.610 252.439 376.805 1.00 26.06 ? 306 ASP B OD2 1 
ATOM   3617 N N   . PHE B 2 307 ? 196.352 248.563 376.928 1.00 14.92 ? 307 PHE B N   1 
ATOM   3618 C CA  . PHE B 2 307 ? 195.723 247.259 376.798 1.00 12.13 ? 307 PHE B CA  1 
ATOM   3619 C C   . PHE B 2 307 ? 194.513 247.249 377.720 1.00 14.17 ? 307 PHE B C   1 
ATOM   3620 O O   . PHE B 2 307 ? 194.556 247.832 378.805 1.00 26.23 ? 307 PHE B O   1 
ATOM   3621 C CB  . PHE B 2 307 ? 196.710 246.137 377.146 1.00 14.07 ? 307 PHE B CB  1 
ATOM   3622 C CG  . PHE B 2 307 ? 196.186 244.756 376.882 1.00 14.62 ? 307 PHE B CG  1 
ATOM   3623 C CD1 . PHE B 2 307 ? 195.896 244.342 375.593 1.00 10.04 ? 307 PHE B CD1 1 
ATOM   3624 C CD2 . PHE B 2 307 ? 196.003 243.863 377.923 1.00 13.15 ? 307 PHE B CD2 1 
ATOM   3625 C CE1 . PHE B 2 307 ? 195.421 243.070 375.350 1.00 13.21 ? 307 PHE B CE1 1 
ATOM   3626 C CE2 . PHE B 2 307 ? 195.531 242.589 377.685 1.00 13.40 ? 307 PHE B CE2 1 
ATOM   3627 C CZ  . PHE B 2 307 ? 195.239 242.192 376.398 1.00 12.56 ? 307 PHE B CZ  1 
ATOM   3628 N N   . ALA B 2 308 ? 193.440 246.584 377.288 1.00 21.38 ? 308 ALA B N   1 
ATOM   3629 C CA  . ALA B 2 308 ? 192.149 246.760 377.946 1.00 18.39 ? 308 ALA B CA  1 
ATOM   3630 C C   . ALA B 2 308 ? 192.182 246.388 379.422 1.00 24.36 ? 308 ALA B C   1 
ATOM   3631 O O   . ALA B 2 308 ? 191.321 246.845 380.181 1.00 27.38 ? 308 ALA B O   1 
ATOM   3632 C CB  . ALA B 2 308 ? 191.081 245.935 377.234 1.00 21.59 ? 308 ALA B CB  1 
ATOM   3633 N N   . THR B 2 309 ? 193.144 245.576 379.848 1.00 25.49 ? 309 THR B N   1 
ATOM   3634 C CA  . THR B 2 309 ? 193.223 245.159 381.241 1.00 24.20 ? 309 THR B CA  1 
ATOM   3635 C C   . THR B 2 309 ? 193.425 246.363 382.157 1.00 22.21 ? 309 THR B C   1 
ATOM   3636 O O   . THR B 2 309 ? 194.207 247.263 381.854 1.00 30.00 ? 309 THR B O   1 
ATOM   3637 C CB  . THR B 2 309 ? 194.366 244.153 381.466 1.00 23.33 ? 309 THR B CB  1 
ATOM   3638 O OG1 . THR B 2 309 ? 194.220 243.538 382.751 1.00 27.46 ? 309 THR B OG1 1 
ATOM   3639 C CG2 . THR B 2 309 ? 195.719 244.848 381.391 1.00 22.90 ? 309 THR B CG2 1 
ATOM   3640 N N   . THR B 2 313 ? 200.055 246.510 381.961 1.00 18.76 ? 313 THR B N   1 
ATOM   3641 C CA  . THR B 2 313 ? 200.531 245.801 380.779 1.00 19.27 ? 313 THR B CA  1 
ATOM   3642 C C   . THR B 2 313 ? 201.940 246.254 380.407 1.00 15.68 ? 313 THR B C   1 
ATOM   3643 O O   . THR B 2 313 ? 202.262 247.438 380.478 1.00 22.06 ? 313 THR B O   1 
ATOM   3644 C CB  . THR B 2 313 ? 199.591 246.014 379.574 1.00 21.06 ? 313 THR B CB  1 
ATOM   3645 O OG1 . THR B 2 313 ? 200.096 245.305 378.437 1.00 23.41 ? 313 THR B OG1 1 
ATOM   3646 C CG2 . THR B 2 313 ? 199.471 247.495 379.233 1.00 21.48 ? 313 THR B CG2 1 
ATOM   3647 N N   . GLU B 2 314 ? 202.777 245.297 380.019 1.00 13.39 ? 314 GLU B N   1 
ATOM   3648 C CA  . GLU B 2 314 ? 204.149 245.564 379.616 1.00 12.53 ? 314 GLU B CA  1 
ATOM   3649 C C   . GLU B 2 314 ? 204.509 244.631 378.474 1.00 9.39  ? 314 GLU B C   1 
ATOM   3650 O O   . GLU B 2 314 ? 204.130 243.457 378.490 1.00 18.49 ? 314 GLU B O   1 
ATOM   3651 C CB  . GLU B 2 314 ? 205.126 245.355 380.781 1.00 12.31 ? 314 GLU B CB  1 
ATOM   3652 C CG  . GLU B 2 314 ? 204.668 245.961 382.094 1.00 18.43 ? 314 GLU B CG  1 
ATOM   3653 C CD  . GLU B 2 314 ? 205.658 245.737 383.220 1.00 25.28 ? 314 GLU B CD  1 
ATOM   3654 O OE1 . GLU B 2 314 ? 206.645 245.001 383.014 1.00 25.78 ? 314 GLU B OE1 1 
ATOM   3655 O OE2 . GLU B 2 314 ? 205.447 246.300 384.315 1.00 25.77 ? 314 GLU B OE2 1 
ATOM   3656 N N   . ILE B 2 315 ? 205.234 245.142 377.483 1.00 12.34 ? 315 ILE B N   1 
ATOM   3657 C CA  . ILE B 2 315 ? 205.688 244.275 376.395 1.00 10.03 ? 315 ILE B CA  1 
ATOM   3658 C C   . ILE B 2 315 ? 207.177 244.492 376.152 1.00 11.95 ? 315 ILE B C   1 
ATOM   3659 O O   . ILE B 2 315 ? 207.661 245.626 376.242 1.00 16.15 ? 315 ILE B O   1 
ATOM   3660 C CB  . ILE B 2 315 ? 204.875 244.497 375.108 1.00 12.16 ? 315 ILE B CB  1 
ATOM   3661 C CG1 . ILE B 2 315 ? 205.032 245.924 374.585 1.00 10.93 ? 315 ILE B CG1 1 
ATOM   3662 C CG2 . ILE B 2 315 ? 203.402 244.176 375.343 1.00 14.24 ? 315 ILE B CG2 1 
ATOM   3663 C CD1 . ILE B 2 315 ? 204.343 246.148 373.257 1.00 16.47 ? 315 ILE B CD1 1 
ATOM   3664 N N   . PRO B 2 316 ? 207.943 243.448 375.857 1.00 9.95  ? 316 PRO B N   1 
ATOM   3665 C CA  . PRO B 2 316 ? 209.379 243.637 375.632 1.00 9.27  ? 316 PRO B CA  1 
ATOM   3666 C C   . PRO B 2 316 ? 209.687 244.270 374.284 1.00 2.17  ? 316 PRO B C   1 
ATOM   3667 O O   . PRO B 2 316 ? 208.947 244.125 373.309 1.00 10.94 ? 316 PRO B O   1 
ATOM   3668 C CB  . PRO B 2 316 ? 209.941 242.214 375.718 1.00 5.91  ? 316 PRO B CB  1 
ATOM   3669 C CG  . PRO B 2 316 ? 208.792 241.330 375.412 1.00 12.70 ? 316 PRO B CG  1 
ATOM   3670 C CD  . PRO B 2 316 ? 207.571 242.024 375.908 1.00 10.92 ? 316 PRO B CD  1 
ATOM   3671 N N   . ILE B 2 317 ? 210.803 244.989 374.252 1.00 6.87  ? 317 ILE B N   1 
ATOM   3672 C CA  . ILE B 2 317 ? 211.419 245.492 373.033 1.00 4.34  ? 317 ILE B CA  1 
ATOM   3673 C C   . ILE B 2 317 ? 212.827 244.920 372.973 1.00 2.37  ? 317 ILE B C   1 
ATOM   3674 O O   . ILE B 2 317 ? 213.584 245.026 373.946 1.00 12.02 ? 317 ILE B O   1 
ATOM   3675 C CB  . ILE B 2 317 ? 211.460 247.032 372.996 1.00 6.34  ? 317 ILE B CB  1 
ATOM   3676 C CG1 . ILE B 2 317 ? 210.043 247.611 373.005 1.00 11.06 ? 317 ILE B CG1 1 
ATOM   3677 C CG2 . ILE B 2 317 ? 212.240 247.508 371.773 1.00 3.34  ? 317 ILE B CG2 1 
ATOM   3678 C CD1 . ILE B 2 317 ? 209.990 249.089 373.346 1.00 6.28  ? 317 ILE B CD1 1 
ATOM   3679 N N   . THR B 2 318 ? 213.177 244.319 371.843 1.00 2.78  ? 318 THR B N   1 
ATOM   3680 C CA  . THR B 2 318 ? 214.470 243.674 371.673 1.00 7.98  ? 318 THR B CA  1 
ATOM   3681 C C   . THR B 2 318 ? 215.189 244.281 370.480 1.00 4.05  ? 318 THR B C   1 
ATOM   3682 O O   . THR B 2 318 ? 214.636 244.335 369.378 1.00 2.82  ? 318 THR B O   1 
ATOM   3683 C CB  . THR B 2 318 ? 214.311 242.163 371.484 1.00 8.71  ? 318 THR B CB  1 
ATOM   3684 O OG1 . THR B 2 318 ? 213.754 241.584 372.670 1.00 10.91 ? 318 THR B OG1 1 
ATOM   3685 C CG2 . THR B 2 318 ? 215.654 241.514 371.184 1.00 7.11  ? 318 THR B CG2 1 
ATOM   3686 N N   . LEU B 2 319 ? 216.417 244.729 370.697 1.00 4.10  ? 319 LEU B N   1 
ATOM   3687 C CA  . LEU B 2 319 ? 217.248 245.275 369.635 1.00 5.95  ? 319 LEU B CA  1 
ATOM   3688 C C   . LEU B 2 319 ? 218.226 244.212 369.159 1.00 7.91  ? 319 LEU B C   1 
ATOM   3689 O O   . LEU B 2 319 ? 218.903 243.574 369.972 1.00 8.89  ? 319 LEU B O   1 
ATOM   3690 C CB  . LEU B 2 319 ? 218.002 246.515 370.115 1.00 6.35  ? 319 LEU B CB  1 
ATOM   3691 C CG  . LEU B 2 319 ? 217.237 247.837 370.027 1.00 13.52 ? 319 LEU B CG  1 
ATOM   3692 C CD1 . LEU B 2 319 ? 215.990 247.815 370.899 1.00 11.97 ? 319 LEU B CD1 1 
ATOM   3693 C CD2 . LEU B 2 319 ? 218.142 249.000 370.408 1.00 12.44 ? 319 LEU B CD2 1 
ATOM   3694 N N   . THR B 2 320 ? 218.292 244.020 367.845 1.00 3.65  ? 320 THR B N   1 
ATOM   3695 C CA  . THR B 2 320 ? 219.256 243.122 367.219 1.00 7.42  ? 320 THR B CA  1 
ATOM   3696 C C   . THR B 2 320 ? 220.017 243.930 366.175 1.00 2.99  ? 320 THR B C   1 
ATOM   3697 O O   . THR B 2 320 ? 219.434 244.381 365.186 1.00 10.10 ? 320 THR B O   1 
ATOM   3698 C CB  . THR B 2 320 ? 218.555 241.910 366.601 1.00 8.57  ? 320 THR B CB  1 
ATOM   3699 O OG1 . THR B 2 320 ? 217.886 241.171 367.628 1.00 15.82 ? 320 THR B OG1 1 
ATOM   3700 C CG2 . THR B 2 320 ? 219.548 241.006 365.913 1.00 12.42 ? 320 THR B CG2 1 
ATOM   3701 N N   . ILE B 2 321 ? 221.312 244.117 366.394 1.00 4.56  ? 321 ILE B N   1 
ATOM   3702 C CA  . ILE B 2 321 ? 222.124 245.017 365.587 1.00 1.90  ? 321 ILE B CA  1 
ATOM   3703 C C   . ILE B 2 321 ? 223.270 244.224 364.979 1.00 2.12  ? 321 ILE B C   1 
ATOM   3704 O O   . ILE B 2 321 ? 223.994 243.524 365.692 1.00 14.59 ? 321 ILE B O   1 
ATOM   3705 C CB  . ILE B 2 321 ? 222.651 246.201 366.419 1.00 4.61  ? 321 ILE B CB  1 
ATOM   3706 C CG1 . ILE B 2 321 ? 221.489 246.889 367.144 1.00 8.96  ? 321 ILE B CG1 1 
ATOM   3707 C CG2 . ILE B 2 321 ? 223.389 247.188 365.526 1.00 9.08  ? 321 ILE B CG2 1 
ATOM   3708 C CD1 . ILE B 2 321 ? 221.902 248.005 368.067 1.00 9.05  ? 321 ILE B CD1 1 
ATOM   3709 N N   . ALA B 2 322 ? 223.417 244.318 363.663 1.00 6.69  ? 322 ALA B N   1 
ATOM   3710 C CA  . ALA B 2 322 ? 224.546 243.716 362.973 1.00 4.76  ? 322 ALA B CA  1 
ATOM   3711 C C   . ALA B 2 322 ? 225.458 244.809 362.444 1.00 7.44  ? 322 ALA B C   1 
ATOM   3712 O O   . ALA B 2 322 ? 225.013 245.614 361.615 1.00 14.81 ? 322 ALA B O   1 
ATOM   3713 C CB  . ALA B 2 322 ? 224.082 242.821 361.828 1.00 4.15  ? 322 ALA B CB  1 
ATOM   3714 N N   . PRO B 2 323 ? 226.712 244.900 362.877 1.00 11.08 ? 323 PRO B N   1 
ATOM   3715 C CA  . PRO B 2 323 ? 227.644 245.798 362.191 1.00 8.25  ? 323 PRO B CA  1 
ATOM   3716 C C   . PRO B 2 323 ? 227.917 245.304 360.779 1.00 3.92  ? 323 PRO B C   1 
ATOM   3717 O O   . PRO B 2 323 ? 227.928 244.103 360.506 1.00 15.70 ? 323 PRO B O   1 
ATOM   3718 C CB  . PRO B 2 323 ? 228.898 245.755 363.070 1.00 5.46  ? 323 PRO B CB  1 
ATOM   3719 C CG  . PRO B 2 323 ? 228.811 244.478 363.803 1.00 12.36 ? 323 PRO B CG  1 
ATOM   3720 C CD  . PRO B 2 323 ? 227.355 244.195 364.001 1.00 4.37  ? 323 PRO B CD  1 
ATOM   3721 N N   . MET B 2 324 ? 228.121 246.253 359.873 1.00 6.71  ? 324 MET B N   1 
ATOM   3722 C CA  . MET B 2 324 ? 228.205 245.974 358.448 1.00 12.82 ? 324 MET B CA  1 
ATOM   3723 C C   . MET B 2 324 ? 229.423 246.665 357.855 1.00 8.28  ? 324 MET B C   1 
ATOM   3724 O O   . MET B 2 324 ? 229.806 247.757 358.281 1.00 13.63 ? 324 MET B O   1 
ATOM   3725 C CB  . MET B 2 324 ? 226.945 246.450 357.708 1.00 9.54  ? 324 MET B CB  1 
ATOM   3726 C CG  . MET B 2 324 ? 225.644 245.844 358.217 1.00 15.43 ? 324 MET B CG  1 
ATOM   3727 S SD  . MET B 2 324 ? 224.202 246.527 357.381 1.00 32.54 ? 324 MET B SD  1 
ATOM   3728 C CE  . MET B 2 324 ? 224.369 245.796 355.758 1.00 11.90 ? 324 MET B CE  1 
ATOM   3729 N N   . CYS B 2 325 ? 230.022 246.016 356.859 1.00 15.43 ? 325 CYS B N   1 
ATOM   3730 C CA  . CYS B 2 325 ? 231.173 246.560 356.142 1.00 9.75  ? 325 CYS B CA  1 
ATOM   3731 C C   . CYS B 2 325 ? 232.247 247.035 357.118 1.00 11.36 ? 325 CYS B C   1 
ATOM   3732 O O   . CYS B 2 325 ? 232.813 248.120 356.982 1.00 16.13 ? 325 CYS B O   1 
ATOM   3733 C CB  . CYS B 2 325 ? 230.745 247.693 355.207 1.00 15.17 ? 325 CYS B CB  1 
ATOM   3734 S SG  . CYS B 2 325 ? 229.540 247.212 353.953 1.00 25.03 ? 325 CYS B SG  1 
ATOM   3735 N N   . CYS B 2 326 ? 232.519 246.206 358.121 1.00 14.06 ? 326 CYS B N   1 
ATOM   3736 C CA  . CYS B 2 326 ? 233.484 246.567 359.149 1.00 16.97 ? 326 CYS B CA  1 
ATOM   3737 C C   . CYS B 2 326 ? 234.890 246.669 358.574 1.00 11.96 ? 326 CYS B C   1 
ATOM   3738 O O   . CYS B 2 326 ? 235.324 245.822 357.789 1.00 20.43 ? 326 CYS B O   1 
ATOM   3739 C CB  . CYS B 2 326 ? 233.471 245.539 360.278 1.00 16.17 ? 326 CYS B CB  1 
ATOM   3740 S SG  . CYS B 2 326 ? 232.004 245.590 361.307 1.00 38.37 ? 326 CYS B SG  1 
ATOM   3741 N N   . GLU B 2 327 ? 235.602 247.716 358.980 1.00 13.65 ? 327 GLU B N   1 
ATOM   3742 C CA  . GLU B 2 327 ? 237.022 247.868 358.701 1.00 14.15 ? 327 GLU B CA  1 
ATOM   3743 C C   . GLU B 2 327 ? 237.709 248.337 359.972 1.00 11.12 ? 327 GLU B C   1 
ATOM   3744 O O   . GLU B 2 327 ? 237.158 249.149 360.718 1.00 14.69 ? 327 GLU B O   1 
ATOM   3745 C CB  . GLU B 2 327 ? 237.285 248.872 357.572 1.00 12.24 ? 327 GLU B CB  1 
ATOM   3746 C CG  . GLU B 2 327 ? 236.491 248.614 356.311 1.00 21.05 ? 327 GLU B CG  1 
ATOM   3747 C CD  . GLU B 2 327 ? 236.787 249.624 355.220 1.00 23.05 ? 327 GLU B CD  1 
ATOM   3748 O OE1 . GLU B 2 327 ? 237.975 249.829 354.900 1.00 27.50 ? 327 GLU B OE1 1 
ATOM   3749 O OE2 . GLU B 2 327 ? 235.829 250.221 354.690 1.00 28.17 ? 327 GLU B OE2 1 
ATOM   3750 N N   . PHE B 2 328 ? 238.907 247.825 360.220 1.00 10.81 ? 328 PHE B N   1 
ATOM   3751 C CA  . PHE B 2 328 ? 239.685 248.219 361.381 1.00 11.10 ? 328 PHE B CA  1 
ATOM   3752 C C   . PHE B 2 328 ? 241.127 248.473 360.969 1.00 14.73 ? 328 PHE B C   1 
ATOM   3753 O O   . PHE B 2 328 ? 241.662 247.811 360.076 1.00 18.31 ? 328 PHE B O   1 
ATOM   3754 C CB  . PHE B 2 328 ? 239.631 247.157 362.481 1.00 9.13  ? 328 PHE B CB  1 
ATOM   3755 C CG  . PHE B 2 328 ? 238.247 246.881 362.991 1.00 15.15 ? 328 PHE B CG  1 
ATOM   3756 C CD1 . PHE B 2 328 ? 237.453 245.917 362.394 1.00 9.28  ? 328 PHE B CD1 1 
ATOM   3757 C CD2 . PHE B 2 328 ? 237.742 247.581 364.072 1.00 12.13 ? 328 PHE B CD2 1 
ATOM   3758 C CE1 . PHE B 2 328 ? 236.182 245.661 362.865 1.00 15.92 ? 328 PHE B CE1 1 
ATOM   3759 C CE2 . PHE B 2 328 ? 236.474 247.329 364.547 1.00 12.81 ? 328 PHE B CE2 1 
ATOM   3760 C CZ  . PHE B 2 328 ? 235.692 246.367 363.943 1.00 11.03 ? 328 PHE B CZ  1 
ATOM   3761 N N   . ASN B 2 329 ? 241.746 249.448 361.627 1.00 12.39 ? 329 ASN B N   1 
ATOM   3762 C CA  . ASN B 2 329 ? 243.119 249.835 361.347 1.00 13.60 ? 329 ASN B CA  1 
ATOM   3763 C C   . ASN B 2 329 ? 243.824 250.167 362.651 1.00 11.77 ? 329 ASN B C   1 
ATOM   3764 O O   . ASN B 2 329 ? 243.190 250.553 363.634 1.00 10.40 ? 329 ASN B O   1 
ATOM   3765 C CB  . ASN B 2 329 ? 243.190 251.047 360.405 1.00 13.20 ? 329 ASN B CB  1 
ATOM   3766 C CG  . ASN B 2 329 ? 243.003 250.672 358.955 1.00 17.92 ? 329 ASN B CG  1 
ATOM   3767 O OD1 . ASN B 2 329 ? 243.970 250.403 358.245 1.00 25.82 ? 329 ASN B OD1 1 
ATOM   3768 N ND2 . ASN B 2 329 ? 241.757 250.660 358.502 1.00 19.65 ? 329 ASN B ND2 1 
ATOM   3769 N N   . GLY B 2 330 ? 245.145 250.022 362.646 1.00 8.17  ? 330 GLY B N   1 
ATOM   3770 C CA  . GLY B 2 330 ? 245.949 250.424 363.782 1.00 6.98  ? 330 GLY B CA  1 
ATOM   3771 C C   . GLY B 2 330 ? 245.950 249.419 364.909 1.00 5.12  ? 330 GLY B C   1 
ATOM   3772 O O   . GLY B 2 330 ? 245.542 249.730 366.030 1.00 9.93  ? 330 GLY B O   1 
ATOM   3773 N N   . LEU B 2 331 ? 246.417 248.210 364.618 1.00 13.38 ? 331 LEU B N   1 
ATOM   3774 C CA  . LEU B 2 331 ? 246.458 247.154 365.618 1.00 8.26  ? 331 LEU B CA  1 
ATOM   3775 C C   . LEU B 2 331 ? 247.559 247.411 366.640 1.00 6.61  ? 331 LEU B C   1 
ATOM   3776 O O   . LEU B 2 331 ? 248.686 247.767 366.288 1.00 12.50 ? 331 LEU B O   1 
ATOM   3777 C CB  . LEU B 2 331 ? 246.683 245.805 364.938 1.00 12.93 ? 331 LEU B CB  1 
ATOM   3778 C CG  . LEU B 2 331 ? 246.702 244.569 365.837 1.00 14.18 ? 331 LEU B CG  1 
ATOM   3779 C CD1 . LEU B 2 331 ? 245.314 244.269 366.379 1.00 11.21 ? 331 LEU B CD1 1 
ATOM   3780 C CD2 . LEU B 2 331 ? 247.260 243.381 365.071 1.00 15.94 ? 331 LEU B CD2 1 
ATOM   3781 N N   . ARG B 2 332 ? 247.222 247.237 367.913 1.00 4.61  ? 332 ARG B N   1 
ATOM   3782 C CA  . ARG B 2 332 ? 248.193 247.287 369.002 1.00 8.72  ? 332 ARG B CA  1 
ATOM   3783 C C   . ARG B 2 332 ? 247.602 246.517 370.181 1.00 3.82  ? 332 ARG B C   1 
ATOM   3784 O O   . ARG B 2 332 ? 246.648 245.749 370.014 1.00 16.20 ? 332 ARG B O   1 
ATOM   3785 C CB  . ARG B 2 332 ? 248.558 248.743 369.350 1.00 12.42 ? 332 ARG B CB  1 
ATOM   3786 C CG  . ARG B 2 332 ? 247.442 249.577 369.982 1.00 10.32 ? 332 ARG B CG  1 
ATOM   3787 C CD  . ARG B 2 332 ? 246.379 249.952 368.972 1.00 12.07 ? 332 ARG B CD  1 
ATOM   3788 N NE  . ARG B 2 332 ? 245.469 250.970 369.484 1.00 13.44 ? 332 ARG B NE  1 
ATOM   3789 C CZ  . ARG B 2 332 ? 244.369 250.718 370.180 1.00 7.33  ? 332 ARG B CZ  1 
ATOM   3790 N NH1 . ARG B 2 332 ? 244.020 249.484 370.503 1.00 12.61 ? 332 ARG B NH1 1 
ATOM   3791 N NH2 . ARG B 2 332 ? 243.597 251.731 370.557 1.00 11.75 ? 332 ARG B NH2 1 
ATOM   3792 N N   . ASN B 2 333 ? 248.177 246.704 371.365 1.00 7.40  ? 333 ASN B N   1 
ATOM   3793 C CA  . ASN B 2 333 ? 247.610 246.108 372.562 1.00 9.15  ? 333 ASN B CA  1 
ATOM   3794 C C   . ASN B 2 333 ? 246.165 246.569 372.741 1.00 9.75  ? 333 ASN B C   1 
ATOM   3795 O O   . ASN B 2 333 ? 245.746 247.609 372.227 1.00 12.69 ? 333 ASN B O   1 
ATOM   3796 C CB  . ASN B 2 333 ? 248.442 246.471 373.793 1.00 7.40  ? 333 ASN B CB  1 
ATOM   3797 C CG  . ASN B 2 333 ? 248.582 247.967 373.984 1.00 9.46  ? 333 ASN B CG  1 
ATOM   3798 O OD1 . ASN B 2 333 ? 249.000 248.681 373.076 1.00 18.00 ? 333 ASN B OD1 1 
ATOM   3799 N ND2 . ASN B 2 333 ? 248.218 248.449 375.163 1.00 9.45  ? 333 ASN B ND2 1 
ATOM   3800 N N   . ILE B 2 334 ? 245.395 245.773 373.482 1.00 10.81 ? 334 ILE B N   1 
ATOM   3801 C CA  . ILE B 2 334 ? 243.963 246.018 373.592 1.00 13.17 ? 334 ILE B CA  1 
ATOM   3802 C C   . ILE B 2 334 ? 243.705 247.245 374.455 1.00 6.10  ? 334 ILE B C   1 
ATOM   3803 O O   . ILE B 2 334 ? 244.335 247.440 375.502 1.00 17.37 ? 334 ILE B O   1 
ATOM   3804 C CB  . ILE B 2 334 ? 243.244 244.784 374.165 1.00 12.45 ? 334 ILE B CB  1 
ATOM   3805 C CG1 . ILE B 2 334 ? 241.738 244.886 373.906 1.00 12.29 ? 334 ILE B CG1 1 
ATOM   3806 C CG2 . ILE B 2 334 ? 243.517 244.649 375.656 1.00 7.88  ? 334 ILE B CG2 1 
ATOM   3807 C CD1 . ILE B 2 334 ? 240.944 243.689 374.387 1.00 11.26 ? 334 ILE B CD1 1 
ATOM   3808 N N   . THR B 2 335 ? 242.775 248.083 374.011 1.00 3.98  ? 335 THR B N   1 
ATOM   3809 C CA  . THR B 2 335 ? 242.272 249.163 374.847 1.00 10.05 ? 335 THR B CA  1 
ATOM   3810 C C   . THR B 2 335 ? 241.375 248.598 375.942 1.00 7.54  ? 335 THR B C   1 
ATOM   3811 O O   . THR B 2 335 ? 240.548 247.717 375.695 1.00 15.94 ? 335 THR B O   1 
ATOM   3812 C CB  . THR B 2 335 ? 241.494 250.173 374.001 1.00 9.16  ? 335 THR B CB  1 
ATOM   3813 O OG1 . THR B 2 335 ? 242.360 250.748 373.015 1.00 18.42 ? 335 THR B OG1 1 
ATOM   3814 C CG2 . THR B 2 335 ? 240.909 251.278 374.875 1.00 11.47 ? 335 THR B CG2 1 
ATOM   3815 N N   . VAL B 2 336 ? 241.540 249.110 377.156 1.00 9.85  ? 336 VAL B N   1 
ATOM   3816 C CA  . VAL B 2 336 ? 240.729 248.692 378.296 1.00 13.70 ? 336 VAL B CA  1 
ATOM   3817 C C   . VAL B 2 336 ? 240.123 249.940 378.927 1.00 14.48 ? 336 VAL B C   1 
ATOM   3818 O O   . VAL B 2 336 ? 240.708 250.508 379.860 1.00 17.32 ? 336 VAL B O   1 
ATOM   3819 C CB  . VAL B 2 336 ? 241.558 247.896 379.316 1.00 14.83 ? 336 VAL B CB  1 
ATOM   3820 C CG1 . VAL B 2 336 ? 240.666 247.389 380.443 1.00 13.03 ? 336 VAL B CG1 1 
ATOM   3821 C CG2 . VAL B 2 336 ? 242.278 246.740 378.634 1.00 13.40 ? 336 VAL B CG2 1 
ATOM   3822 N N   . PRO B 2 337 ? 238.973 250.412 378.451 1.00 19.71 ? 337 PRO B N   1 
ATOM   3823 C CA  . PRO B 2 337 ? 238.425 251.666 378.980 1.00 19.47 ? 337 PRO B CA  1 
ATOM   3824 C C   . PRO B 2 337 ? 238.081 251.557 380.457 1.00 14.78 ? 337 PRO B C   1 
ATOM   3825 O O   . PRO B 2 337 ? 237.684 250.502 380.952 1.00 24.47 ? 337 PRO B O   1 
ATOM   3826 C CB  . PRO B 2 337 ? 237.173 251.898 378.126 1.00 16.52 ? 337 PRO B CB  1 
ATOM   3827 C CG  . PRO B 2 337 ? 236.811 250.558 377.601 1.00 18.13 ? 337 PRO B CG  1 
ATOM   3828 C CD  . PRO B 2 337 ? 238.099 249.817 377.427 1.00 15.88 ? 337 PRO B CD  1 
ATOM   3829 N N   . ARG B 2 338 ? 238.249 252.672 381.161 1.00 19.16 ? 338 ARG B N   1 
ATOM   3830 C CA  . ARG B 2 338 ? 237.797 252.757 382.542 1.00 22.90 ? 338 ARG B CA  1 
ATOM   3831 C C   . ARG B 2 338 ? 236.279 252.641 382.591 1.00 17.96 ? 338 ARG B C   1 
ATOM   3832 O O   . ARG B 2 338 ? 235.574 253.150 381.717 1.00 23.51 ? 338 ARG B O   1 
ATOM   3833 C CB  . ARG B 2 338 ? 238.251 254.078 383.163 1.00 20.68 ? 338 ARG B CB  1 
ATOM   3834 C CG  . ARG B 2 338 ? 238.041 254.174 384.666 1.00 22.37 ? 338 ARG B CG  1 
ATOM   3835 C CD  . ARG B 2 338 ? 238.029 255.620 385.132 1.00 23.14 ? 338 ARG B CD  1 
ATOM   3836 N NE  . ARG B 2 338 ? 239.314 256.285 384.961 1.00 29.34 ? 338 ARG B NE  1 
ATOM   3837 C CZ  . ARG B 2 338 ? 239.475 257.601 384.903 1.00 29.71 ? 338 ARG B CZ  1 
ATOM   3838 N NH1 . ARG B 2 338 ? 238.443 258.428 384.949 1.00 26.75 ? 338 ARG B NH1 1 
ATOM   3839 N NH2 . ARG B 2 338 ? 240.701 258.100 384.788 1.00 29.74 ? 338 ARG B NH2 1 
ATOM   3840 N N   . THR B 2 339 ? 235.775 251.966 383.618 1.00 20.05 ? 339 THR B N   1 
ATOM   3841 C CA  . THR B 2 339 ? 234.350 251.704 383.759 1.00 27.35 ? 339 THR B CA  1 
ATOM   3842 C C   . THR B 2 339 ? 233.852 252.186 385.117 1.00 27.99 ? 339 THR B C   1 
ATOM   3843 O O   . THR B 2 339 ? 234.630 252.531 386.008 1.00 27.68 ? 339 THR B O   1 
ATOM   3844 C CB  . THR B 2 339 ? 234.044 250.211 383.581 1.00 27.01 ? 339 THR B CB  1 
ATOM   3845 O OG1 . THR B 2 339 ? 234.970 249.433 384.348 1.00 29.79 ? 339 THR B OG1 1 
ATOM   3846 C CG2 . THR B 2 339 ? 234.137 249.818 382.115 1.00 24.69 ? 339 THR B CG2 1 
ATOM   3847 N N   . GLN B 2 340 ? 232.527 252.187 385.255 1.00 32.59 ? 340 GLN B N   1 
ATOM   3848 C CA  . GLN B 2 340 ? 231.830 252.686 386.444 1.00 33.28 ? 340 GLN B CA  1 
ATOM   3849 C C   . GLN B 2 340 ? 232.424 253.997 386.957 1.00 35.92 ? 340 GLN B C   1 
ATOM   3850 O O   . GLN B 2 340 ? 231.914 255.071 386.641 1.00 35.59 ? 340 GLN B O   1 
ATOM   3851 C CB  . GLN B 2 340 ? 231.829 251.631 387.563 1.00 33.31 ? 340 GLN B CB  1 
ATOM   3852 C CG  . GLN B 2 340 ? 233.195 251.110 387.996 1.00 35.03 ? 340 GLN B CG  1 
ATOM   3853 C CD  . GLN B 2 340 ? 233.100 250.125 389.145 1.00 36.68 ? 340 GLN B CD  1 
ATOM   3854 O OE1 . GLN B 2 340 ? 232.446 249.087 389.037 1.00 37.73 ? 340 GLN B OE1 1 
ATOM   3855 N NE2 . GLN B 2 340 ? 233.749 250.449 390.257 1.00 36.83 ? 340 GLN B NE2 1 
ATOM   3856 O OXT . GLN B 2 340 ? 233.411 254.029 387.691 1.00 34.69 ? 340 GLN B OXT 1 
ATOM   3857 N N   . GLY C 3 1   ? 246.906 307.430 336.980 1.00 11.63 ? 1   GLY C N   1 
ATOM   3858 C CA  . GLY C 3 1   ? 246.083 306.187 337.036 1.00 6.30  ? 1   GLY C CA  1 
ATOM   3859 C C   . GLY C 3 1   ? 244.850 306.249 336.157 1.00 7.38  ? 1   GLY C C   1 
ATOM   3860 O O   . GLY C 3 1   ? 244.548 307.284 335.564 1.00 17.31 ? 1   GLY C O   1 
ATOM   3861 N N   . LEU C 3 2   ? 244.141 305.133 336.070 1.00 8.42  ? 2   LEU C N   1 
ATOM   3862 C CA  . LEU C 3 2   ? 242.896 305.097 335.320 1.00 6.10  ? 2   LEU C CA  1 
ATOM   3863 C C   . LEU C 3 2   ? 241.871 306.013 335.985 1.00 5.87  ? 2   LEU C C   1 
ATOM   3864 O O   . LEU C 3 2   ? 241.613 305.873 337.187 1.00 8.77  ? 2   LEU C O   1 
ATOM   3865 C CB  . LEU C 3 2   ? 242.360 303.668 335.254 1.00 6.60  ? 2   LEU C CB  1 
ATOM   3866 C CG  . LEU C 3 2   ? 241.003 303.469 334.577 1.00 5.98  ? 2   LEU C CG  1 
ATOM   3867 C CD1 . LEU C 3 2   ? 241.123 303.649 333.078 1.00 10.61 ? 2   LEU C CD1 1 
ATOM   3868 C CD2 . LEU C 3 2   ? 240.435 302.100 334.920 1.00 7.91  ? 2   LEU C CD2 1 
ATOM   3869 N N   . PRO C 3 3   ? 241.268 306.952 335.255 1.00 8.37  ? 3   PRO C N   1 
ATOM   3870 C CA  . PRO C 3 3   ? 240.251 307.816 335.875 1.00 3.67  ? 3   PRO C CA  1 
ATOM   3871 C C   . PRO C 3 3   ? 239.064 307.001 336.365 1.00 1.20  ? 3   PRO C C   1 
ATOM   3872 O O   . PRO C 3 3   ? 238.430 306.270 335.602 1.00 6.37  ? 3   PRO C O   1 
ATOM   3873 C CB  . PRO C 3 3   ? 239.861 308.773 334.743 1.00 5.45  ? 3   PRO C CB  1 
ATOM   3874 C CG  . PRO C 3 3   ? 240.996 308.725 333.781 1.00 5.61  ? 3   PRO C CG  1 
ATOM   3875 C CD  . PRO C 3 3   ? 241.531 307.335 333.858 1.00 4.88  ? 3   PRO C CD  1 
ATOM   3876 N N   . VAL C 3 4   ? 238.770 307.125 337.659 1.00 2.71  ? 4   VAL C N   1 
ATOM   3877 C CA  . VAL C 3 4   ? 237.650 306.436 338.279 1.00 3.71  ? 4   VAL C CA  1 
ATOM   3878 C C   . VAL C 3 4   ? 236.827 307.450 339.059 1.00 1.73  ? 4   VAL C C   1 
ATOM   3879 O O   . VAL C 3 4   ? 237.311 308.514 339.451 1.00 9.10  ? 4   VAL C O   1 
ATOM   3880 C CB  . VAL C 3 4   ? 238.104 305.283 339.206 1.00 1.94  ? 4   VAL C CB  1 
ATOM   3881 C CG1 . VAL C 3 4   ? 238.825 304.212 338.405 1.00 4.64  ? 4   VAL C CG1 1 
ATOM   3882 C CG2 . VAL C 3 4   ? 238.984 305.807 340.331 1.00 5.46  ? 4   VAL C CG2 1 
ATOM   3883 N N   . LEU C 3 5   ? 235.564 307.100 339.287 1.00 0.01  ? 5   LEU C N   1 
ATOM   3884 C CA  . LEU C 3 5   ? 234.636 307.949 340.028 1.00 6.17  ? 5   LEU C CA  1 
ATOM   3885 C C   . LEU C 3 5   ? 233.861 307.060 340.989 1.00 0.43  ? 5   LEU C C   1 
ATOM   3886 O O   . LEU C 3 5   ? 233.092 306.198 340.556 1.00 10.83 ? 5   LEU C O   1 
ATOM   3887 C CB  . LEU C 3 5   ? 233.699 308.697 339.078 1.00 3.82  ? 5   LEU C CB  1 
ATOM   3888 C CG  . LEU C 3 5   ? 232.841 309.819 339.672 1.00 6.78  ? 5   LEU C CG  1 
ATOM   3889 C CD1 . LEU C 3 5   ? 232.400 310.778 338.577 1.00 6.75  ? 5   LEU C CD1 1 
ATOM   3890 C CD2 . LEU C 3 5   ? 231.629 309.269 340.411 1.00 7.15  ? 5   LEU C CD2 1 
ATOM   3891 N N   . ASN C 3 6   ? 234.060 307.265 342.287 1.00 1.25  ? 6   ASN C N   1 
ATOM   3892 C CA  . ASN C 3 6   ? 233.422 306.422 343.290 1.00 5.68  ? 6   ASN C CA  1 
ATOM   3893 C C   . ASN C 3 6   ? 231.939 306.758 343.381 1.00 1.38  ? 6   ASN C C   1 
ATOM   3894 O O   . ASN C 3 6   ? 231.570 307.911 343.620 1.00 11.38 ? 6   ASN C O   1 
ATOM   3895 C CB  . ASN C 3 6   ? 234.099 306.611 344.644 1.00 4.26  ? 6   ASN C CB  1 
ATOM   3896 C CG  . ASN C 3 6   ? 235.609 306.500 344.560 1.00 6.46  ? 6   ASN C CG  1 
ATOM   3897 O OD1 . ASN C 3 6   ? 236.300 307.485 344.310 1.00 14.21 ? 6   ASN C OD1 1 
ATOM   3898 N ND2 . ASN C 3 6   ? 236.128 305.299 344.770 1.00 4.59  ? 6   ASN C ND2 1 
ATOM   3899 N N   . THR C 3 7   ? 231.097 305.757 343.190 1.00 1.95  ? 7   THR C N   1 
ATOM   3900 C CA  . THR C 3 7   ? 229.653 305.933 343.194 1.00 7.47  ? 7   THR C CA  1 
ATOM   3901 C C   . THR C 3 7   ? 229.114 305.827 344.610 1.00 3.52  ? 7   THR C C   1 
ATOM   3902 O O   . THR C 3 7   ? 229.824 305.440 345.538 1.00 6.51  ? 7   THR C O   1 
ATOM   3903 C CB  . THR C 3 7   ? 229.001 304.886 342.295 1.00 9.65  ? 7   THR C CB  1 
ATOM   3904 O OG1 . THR C 3 7   ? 229.213 303.579 342.841 1.00 13.66 ? 7   THR C OG1 1 
ATOM   3905 C CG2 . THR C 3 7   ? 229.577 304.947 340.890 1.00 1.93  ? 7   THR C CG2 1 
ATOM   3906 N N   . PRO C 3 8   ? 227.847 306.181 344.819 1.00 8.79  ? 8   PRO C N   1 
ATOM   3907 C CA  . PRO C 3 8   ? 227.213 305.883 346.107 1.00 5.99  ? 8   PRO C CA  1 
ATOM   3908 C C   . PRO C 3 8   ? 227.240 304.387 346.382 1.00 2.50  ? 8   PRO C C   1 
ATOM   3909 O O   . PRO C 3 8   ? 227.208 303.564 345.467 1.00 6.70  ? 8   PRO C O   1 
ATOM   3910 C CB  . PRO C 3 8   ? 225.782 306.402 345.930 1.00 5.15  ? 8   PRO C CB  1 
ATOM   3911 C CG  . PRO C 3 8   ? 225.892 307.449 344.871 1.00 6.90  ? 8   PRO C CG  1 
ATOM   3912 C CD  . PRO C 3 8   ? 226.963 306.966 343.939 1.00 6.57  ? 8   PRO C CD  1 
ATOM   3913 N N   . GLY C 3 9   ? 227.317 304.043 347.664 1.00 5.00  ? 9   GLY C N   1 
ATOM   3914 C CA  . GLY C 3 9   ? 227.522 302.677 348.083 1.00 7.72  ? 9   GLY C CA  1 
ATOM   3915 C C   . GLY C 3 9   ? 228.971 302.308 348.308 1.00 7.96  ? 9   GLY C C   1 
ATOM   3916 O O   . GLY C 3 9   ? 229.239 301.290 348.955 1.00 9.16  ? 9   GLY C O   1 
ATOM   3917 N N   . SER C 3 10  ? 229.910 303.106 347.801 1.00 4.78  ? 10  SER C N   1 
ATOM   3918 C CA  . SER C 3 10  ? 231.323 302.866 348.060 1.00 2.74  ? 10  SER C CA  1 
ATOM   3919 C C   . SER C 3 10  ? 231.604 302.915 349.555 1.00 3.93  ? 10  SER C C   1 
ATOM   3920 O O   . SER C 3 10  ? 231.096 303.780 350.272 1.00 8.22  ? 10  SER C O   1 
ATOM   3921 C CB  . SER C 3 10  ? 232.183 303.904 347.336 1.00 4.05  ? 10  SER C CB  1 
ATOM   3922 O OG  . SER C 3 10  ? 231.960 303.879 345.939 1.00 5.22  ? 10  SER C OG  1 
ATOM   3923 N N   . ASN C 3 11  ? 232.420 301.973 350.021 1.00 5.38  ? 11  ASN C N   1 
ATOM   3924 C CA  . ASN C 3 11  ? 232.921 301.849 351.387 1.00 4.38  ? 11  ASN C CA  1 
ATOM   3925 C C   . ASN C 3 11  ? 231.877 301.294 352.350 1.00 0.01  ? 11  ASN C C   1 
ATOM   3926 O O   . ASN C 3 11  ? 232.176 301.169 353.540 1.00 16.39 ? 11  ASN C O   1 
ATOM   3927 C CB  . ASN C 3 11  ? 233.441 303.181 351.954 1.00 6.72  ? 11  ASN C CB  1 
ATOM   3928 C CG  . ASN C 3 11  ? 234.576 303.759 351.136 1.00 9.06  ? 11  ASN C CG  1 
ATOM   3929 O OD1 . ASN C 3 11  ? 235.345 303.029 350.517 1.00 16.61 ? 11  ASN C OD1 1 
ATOM   3930 N ND2 . ASN C 3 11  ? 234.686 305.079 351.131 1.00 12.54 ? 11  ASN C ND2 1 
ATOM   3931 N N   . GLN C 3 12  ? 230.673 300.969 351.893 1.00 1.65  ? 12  GLN C N   1 
ATOM   3932 C CA  . GLN C 3 12  ? 229.688 300.354 352.766 1.00 7.72  ? 12  GLN C CA  1 
ATOM   3933 C C   . GLN C 3 12  ? 229.995 298.870 352.946 1.00 0.01  ? 12  GLN C C   1 
ATOM   3934 O O   . GLN C 3 12  ? 230.724 298.259 352.162 1.00 2.03  ? 12  GLN C O   1 
ATOM   3935 C CB  . GLN C 3 12  ? 228.277 300.526 352.200 1.00 3.88  ? 12  GLN C CB  1 
ATOM   3936 C CG  . GLN C 3 12  ? 227.936 299.556 351.077 1.00 0.01  ? 12  GLN C CG  1 
ATOM   3937 C CD  . GLN C 3 12  ? 226.697 299.966 350.305 1.00 7.55  ? 12  GLN C CD  1 
ATOM   3938 O OE1 . GLN C 3 12  ? 225.975 300.873 350.707 1.00 8.69  ? 12  GLN C OE1 1 
ATOM   3939 N NE2 . GLN C 3 12  ? 226.449 299.298 349.189 1.00 3.51  ? 12  GLN C NE2 1 
ATOM   3940 N N   . TYR C 3 13  ? 229.433 298.295 354.002 1.00 4.57  ? 13  TYR C N   1 
ATOM   3941 C CA  . TYR C 3 13  ? 229.453 296.851 354.217 1.00 5.14  ? 13  TYR C CA  1 
ATOM   3942 C C   . TYR C 3 13  ? 228.005 296.373 354.243 1.00 3.63  ? 13  TYR C C   1 
ATOM   3943 O O   . TYR C 3 13  ? 227.311 296.515 355.253 1.00 7.73  ? 13  TYR C O   1 
ATOM   3944 C CB  . TYR C 3 13  ? 230.192 296.477 355.500 1.00 0.47  ? 13  TYR C CB  1 
ATOM   3945 C CG  . TYR C 3 13  ? 229.982 295.038 355.929 1.00 4.30  ? 13  TYR C CG  1 
ATOM   3946 C CD1 . TYR C 3 13  ? 229.872 294.020 354.990 1.00 4.49  ? 13  TYR C CD1 1 
ATOM   3947 C CD2 . TYR C 3 13  ? 229.908 294.697 357.273 1.00 0.01  ? 13  TYR C CD2 1 
ATOM   3948 C CE1 . TYR C 3 13  ? 229.676 292.712 355.375 1.00 2.74  ? 13  TYR C CE1 1 
ATOM   3949 C CE2 . TYR C 3 13  ? 229.717 293.386 357.667 1.00 5.76  ? 13  TYR C CE2 1 
ATOM   3950 C CZ  . TYR C 3 13  ? 229.604 292.398 356.712 1.00 6.50  ? 13  TYR C CZ  1 
ATOM   3951 O OH  . TYR C 3 13  ? 229.412 291.093 357.085 1.00 13.95 ? 13  TYR C OH  1 
ATOM   3952 N N   . LEU C 3 14  ? 227.560 295.815 353.126 1.00 4.60  ? 14  LEU C N   1 
ATOM   3953 C CA  . LEU C 3 14  ? 226.269 295.151 353.043 1.00 1.87  ? 14  LEU C CA  1 
ATOM   3954 C C   . LEU C 3 14  ? 226.473 293.681 353.386 1.00 0.01  ? 14  LEU C C   1 
ATOM   3955 O O   . LEU C 3 14  ? 227.219 292.979 352.698 1.00 6.55  ? 14  LEU C O   1 
ATOM   3956 C CB  . LEU C 3 14  ? 225.671 295.315 351.646 1.00 8.32  ? 14  LEU C CB  1 
ATOM   3957 C CG  . LEU C 3 14  ? 224.463 294.446 351.284 1.00 7.66  ? 14  LEU C CG  1 
ATOM   3958 C CD1 . LEU C 3 14  ? 223.270 294.767 352.170 1.00 8.62  ? 14  LEU C CD1 1 
ATOM   3959 C CD2 . LEU C 3 14  ? 224.107 294.622 349.818 1.00 4.22  ? 14  LEU C CD2 1 
ATOM   3960 N N   . THR C 3 15  ? 225.819 293.220 354.454 1.00 0.32  ? 15  THR C N   1 
ATOM   3961 C CA  . THR C 3 15  ? 226.022 291.849 354.910 1.00 5.71  ? 15  THR C CA  1 
ATOM   3962 C C   . THR C 3 15  ? 225.582 290.827 353.871 1.00 3.01  ? 15  THR C C   1 
ATOM   3963 O O   . THR C 3 15  ? 226.008 289.670 353.939 1.00 12.12 ? 15  THR C O   1 
ATOM   3964 C CB  . THR C 3 15  ? 225.275 291.607 356.225 1.00 3.98  ? 15  THR C CB  1 
ATOM   3965 O OG1 . THR C 3 15  ? 223.877 291.863 356.047 1.00 12.67 ? 15  THR C OG1 1 
ATOM   3966 C CG2 . THR C 3 15  ? 225.818 292.508 357.323 1.00 2.74  ? 15  THR C CG2 1 
ATOM   3967 N N   . ALA C 3 16  ? 224.750 291.225 352.911 1.00 2.67  ? 16  ALA C N   1 
ATOM   3968 C CA  . ALA C 3 16  ? 224.307 290.341 351.844 1.00 7.37  ? 16  ALA C CA  1 
ATOM   3969 C C   . ALA C 3 16  ? 225.127 290.500 350.568 1.00 7.39  ? 16  ALA C C   1 
ATOM   3970 O O   . ALA C 3 16  ? 224.797 289.879 349.555 1.00 14.30 ? 16  ALA C O   1 
ATOM   3971 C CB  . ALA C 3 16  ? 222.826 290.579 351.546 1.00 6.56  ? 16  ALA C CB  1 
ATOM   3972 N N   . ASP C 3 17  ? 226.186 291.306 350.592 1.00 9.66  ? 17  ASP C N   1 
ATOM   3973 C CA  . ASP C 3 17  ? 226.994 291.493 349.396 1.00 11.69 ? 17  ASP C CA  1 
ATOM   3974 C C   . ASP C 3 17  ? 227.730 290.203 349.043 1.00 2.40  ? 17  ASP C C   1 
ATOM   3975 O O   . ASP C 3 17  ? 227.885 289.297 349.864 1.00 15.28 ? 17  ASP C O   1 
ATOM   3976 C CB  . ASP C 3 17  ? 227.993 292.639 349.584 1.00 10.35 ? 17  ASP C CB  1 
ATOM   3977 C CG  . ASP C 3 17  ? 229.097 292.312 350.586 1.00 10.52 ? 17  ASP C CG  1 
ATOM   3978 O OD1 . ASP C 3 17  ? 229.131 291.190 351.128 1.00 10.58 ? 17  ASP C OD1 1 
ATOM   3979 O OD2 . ASP C 3 17  ? 229.937 293.195 350.845 1.00 14.51 ? 17  ASP C OD2 1 
ATOM   3980 N N   . ASN C 3 18  ? 228.177 290.123 347.792 1.00 8.95  ? 18  ASN C N   1 
ATOM   3981 C CA  . ASN C 3 18  ? 228.946 288.983 347.298 1.00 9.78  ? 18  ASN C CA  1 
ATOM   3982 C C   . ASN C 3 18  ? 230.129 289.539 346.512 1.00 10.91 ? 18  ASN C C   1 
ATOM   3983 O O   . ASN C 3 18  ? 230.068 289.670 345.288 1.00 20.49 ? 18  ASN C O   1 
ATOM   3984 C CB  . ASN C 3 18  ? 228.072 288.068 346.448 1.00 13.58 ? 18  ASN C CB  1 
ATOM   3985 C CG  . ASN C 3 18  ? 228.789 286.810 346.015 1.00 13.26 ? 18  ASN C CG  1 
ATOM   3986 O OD1 . ASN C 3 18  ? 229.749 286.374 346.649 1.00 17.55 ? 18  ASN C OD1 1 
ATOM   3987 N ND2 . ASN C 3 18  ? 228.325 286.217 344.926 1.00 18.30 ? 18  ASN C ND2 1 
ATOM   3988 N N   . TYR C 3 19  ? 231.211 289.843 347.220 1.00 12.98 ? 19  TYR C N   1 
ATOM   3989 C CA  . TYR C 3 19  ? 232.420 290.395 346.633 1.00 9.90  ? 19  TYR C CA  1 
ATOM   3990 C C   . TYR C 3 19  ? 233.590 289.459 346.897 1.00 11.18 ? 19  TYR C C   1 
ATOM   3991 O O   . TYR C 3 19  ? 233.570 288.651 347.827 1.00 16.67 ? 19  TYR C O   1 
ATOM   3992 C CB  . TYR C 3 19  ? 232.751 291.780 347.206 1.00 7.91  ? 19  TYR C CB  1 
ATOM   3993 C CG  . TYR C 3 19  ? 231.746 292.866 346.902 1.00 8.95  ? 19  TYR C CG  1 
ATOM   3994 C CD1 . TYR C 3 19  ? 231.176 292.990 345.642 1.00 6.70  ? 19  TYR C CD1 1 
ATOM   3995 C CD2 . TYR C 3 19  ? 231.375 293.776 347.881 1.00 4.36  ? 19  TYR C CD2 1 
ATOM   3996 C CE1 . TYR C 3 19  ? 230.260 293.988 345.369 1.00 5.15  ? 19  TYR C CE1 1 
ATOM   3997 C CE2 . TYR C 3 19  ? 230.466 294.772 347.619 1.00 9.49  ? 19  TYR C CE2 1 
ATOM   3998 C CZ  . TYR C 3 19  ? 229.910 294.876 346.363 1.00 7.75  ? 19  TYR C CZ  1 
ATOM   3999 O OH  . TYR C 3 19  ? 229.001 295.875 346.109 1.00 18.06 ? 19  TYR C OH  1 
ATOM   4000 N N   . GLN C 3 20  ? 234.614 289.579 346.060 1.00 13.75 ? 20  GLN C N   1 
ATOM   4001 C CA  . GLN C 3 20  ? 235.870 288.900 346.322 1.00 15.93 ? 20  GLN C CA  1 
ATOM   4002 C C   . GLN C 3 20  ? 236.607 289.588 347.469 1.00 6.86  ? 20  GLN C C   1 
ATOM   4003 O O   . GLN C 3 20  ? 236.387 290.763 347.770 1.00 15.01 ? 20  GLN C O   1 
ATOM   4004 C CB  . GLN C 3 20  ? 236.748 288.887 345.071 1.00 12.32 ? 20  GLN C CB  1 
ATOM   4005 C CG  . GLN C 3 20  ? 236.081 288.282 343.849 1.00 11.95 ? 20  GLN C CG  1 
ATOM   4006 C CD  . GLN C 3 20  ? 235.703 286.829 344.049 1.00 16.56 ? 20  GLN C CD  1 
ATOM   4007 O OE1 . GLN C 3 20  ? 236.529 286.011 344.450 1.00 24.71 ? 20  GLN C OE1 1 
ATOM   4008 N NE2 . GLN C 3 20  ? 234.446 286.503 343.775 1.00 21.79 ? 20  GLN C NE2 1 
ATOM   4009 N N   . SER C 3 21  ? 237.487 288.836 348.116 1.00 13.92 ? 21  SER C N   1 
ATOM   4010 C CA  . SER C 3 21  ? 238.319 289.365 349.185 1.00 12.67 ? 21  SER C CA  1 
ATOM   4011 C C   . SER C 3 21  ? 239.616 288.572 349.215 1.00 10.53 ? 21  SER C C   1 
ATOM   4012 O O   . SER C 3 21  ? 239.654 287.424 348.758 1.00 18.63 ? 21  SER C O   1 
ATOM   4013 C CB  . SER C 3 21  ? 237.604 289.294 350.541 1.00 14.39 ? 21  SER C CB  1 
ATOM   4014 O OG  . SER C 3 21  ? 237.314 287.958 350.905 1.00 18.66 ? 21  SER C OG  1 
ATOM   4015 N N   . PRO C 3 22  ? 240.698 289.158 349.728 1.00 9.52  ? 22  PRO C N   1 
ATOM   4016 C CA  . PRO C 3 22  ? 241.980 288.442 349.740 1.00 8.51  ? 22  PRO C CA  1 
ATOM   4017 C C   . PRO C 3 22  ? 241.950 287.230 350.661 1.00 7.82  ? 22  PRO C C   1 
ATOM   4018 O O   . PRO C 3 22  ? 241.318 287.243 351.719 1.00 13.33 ? 22  PRO C O   1 
ATOM   4019 C CB  . PRO C 3 22  ? 242.971 289.501 350.237 1.00 10.97 ? 22  PRO C CB  1 
ATOM   4020 C CG  . PRO C 3 22  ? 242.141 290.455 351.021 1.00 8.32  ? 22  PRO C CG  1 
ATOM   4021 C CD  . PRO C 3 22  ? 240.813 290.500 350.325 1.00 8.15  ? 22  PRO C CD  1 
ATOM   4022 N N   . CYS C 3 23  ? 242.658 286.181 350.253 1.00 14.10 ? 23  CYS C N   1 
ATOM   4023 C CA  . CYS C 3 23  ? 242.766 284.976 351.062 1.00 9.60  ? 23  CYS C CA  1 
ATOM   4024 C C   . CYS C 3 23  ? 243.828 285.170 352.137 1.00 8.97  ? 23  CYS C C   1 
ATOM   4025 O O   . CYS C 3 23  ? 244.969 285.530 351.837 1.00 15.37 ? 23  CYS C O   1 
ATOM   4026 C CB  . CYS C 3 23  ? 243.112 283.771 350.188 1.00 14.66 ? 23  CYS C CB  1 
ATOM   4027 S SG  . CYS C 3 23  ? 243.190 282.203 351.090 1.00 27.85 ? 23  CYS C SG  1 
ATOM   4028 N N   . ALA C 3 24  ? 243.451 284.929 353.391 1.00 6.61  ? 24  ALA C N   1 
ATOM   4029 C CA  . ALA C 3 24  ? 244.398 285.051 354.490 1.00 10.39 ? 24  ALA C CA  1 
ATOM   4030 C C   . ALA C 3 24  ? 245.343 283.860 354.589 1.00 6.27  ? 24  ALA C C   1 
ATOM   4031 O O   . ALA C 3 24  ? 246.360 283.952 355.282 1.00 11.70 ? 24  ALA C O   1 
ATOM   4032 C CB  . ALA C 3 24  ? 243.650 285.223 355.813 1.00 8.06  ? 24  ALA C CB  1 
ATOM   4033 N N   . ILE C 3 25  ? 245.034 282.753 353.921 1.00 7.24  ? 25  ILE C N   1 
ATOM   4034 C CA  . ILE C 3 25  ? 245.867 281.554 353.982 1.00 9.49  ? 25  ILE C CA  1 
ATOM   4035 C C   . ILE C 3 25  ? 246.119 281.076 352.557 1.00 6.03  ? 25  ILE C C   1 
ATOM   4036 O O   . ILE C 3 25  ? 245.573 280.043 352.144 1.00 9.54  ? 25  ILE C O   1 
ATOM   4037 C CB  . ILE C 3 25  ? 245.210 280.458 354.836 1.00 14.09 ? 25  ILE C CB  1 
ATOM   4038 C CG1 . ILE C 3 25  ? 244.699 281.042 356.156 1.00 8.25  ? 25  ILE C CG1 1 
ATOM   4039 C CG2 . ILE C 3 25  ? 246.202 279.333 355.111 1.00 8.27  ? 25  ILE C CG2 1 
ATOM   4040 C CD1 . ILE C 3 25  ? 244.025 280.030 357.051 1.00 10.72 ? 25  ILE C CD1 1 
ATOM   4041 N N   . PRO C 3 26  ? 246.929 281.785 351.775 1.00 6.91  ? 26  PRO C N   1 
ATOM   4042 C CA  . PRO C 3 26  ? 247.134 281.388 350.377 1.00 11.17 ? 26  PRO C CA  1 
ATOM   4043 C C   . PRO C 3 26  ? 247.821 280.035 350.261 1.00 6.34  ? 26  PRO C C   1 
ATOM   4044 O O   . PRO C 3 26  ? 248.598 279.629 351.126 1.00 10.73 ? 26  PRO C O   1 
ATOM   4045 C CB  . PRO C 3 26  ? 248.013 282.512 349.813 1.00 7.86  ? 26  PRO C CB  1 
ATOM   4046 C CG  . PRO C 3 26  ? 248.691 283.096 351.000 1.00 12.82 ? 26  PRO C CG  1 
ATOM   4047 C CD  . PRO C 3 26  ? 247.714 282.979 352.131 1.00 11.03 ? 26  PRO C CD  1 
ATOM   4048 N N   . GLU C 3 27  ? 247.517 279.339 349.166 1.00 9.65  ? 27  GLU C N   1 
ATOM   4049 C CA  . GLU C 3 27  ? 248.138 278.057 348.835 1.00 8.76  ? 27  GLU C CA  1 
ATOM   4050 C C   . GLU C 3 27  ? 247.855 276.995 349.894 1.00 9.99  ? 27  GLU C C   1 
ATOM   4051 O O   . GLU C 3 27  ? 248.664 276.092 350.110 1.00 14.08 ? 27  GLU C O   1 
ATOM   4052 C CB  . GLU C 3 27  ? 249.650 278.211 348.634 1.00 15.27 ? 27  GLU C CB  1 
ATOM   4053 C CG  . GLU C 3 27  ? 250.030 279.224 347.570 1.00 12.52 ? 27  GLU C CG  1 
ATOM   4054 C CD  . GLU C 3 27  ? 249.523 278.842 346.193 1.00 15.54 ? 27  GLU C CD  1 
ATOM   4055 O OE1 . GLU C 3 27  ? 249.700 277.673 345.795 1.00 21.29 ? 27  GLU C OE1 1 
ATOM   4056 O OE2 . GLU C 3 27  ? 248.939 279.710 345.514 1.00 24.41 ? 27  GLU C OE2 1 
ATOM   4057 N N   . PHE C 3 28  ? 246.706 277.085 350.556 1.00 11.04 ? 28  PHE C N   1 
ATOM   4058 C CA  . PHE C 3 28  ? 246.316 276.078 351.532 1.00 6.51  ? 28  PHE C CA  1 
ATOM   4059 C C   . PHE C 3 28  ? 245.823 274.828 350.810 1.00 5.38  ? 28  PHE C C   1 
ATOM   4060 O O   . PHE C 3 28  ? 244.948 274.905 349.943 1.00 10.62 ? 28  PHE C O   1 
ATOM   4061 C CB  . PHE C 3 28  ? 245.231 276.631 352.456 1.00 10.21 ? 28  PHE C CB  1 
ATOM   4062 C CG  . PHE C 3 28  ? 244.819 275.689 353.554 1.00 10.01 ? 28  PHE C CG  1 
ATOM   4063 C CD1 . PHE C 3 28  ? 245.469 275.698 354.778 1.00 8.76  ? 28  PHE C CD1 1 
ATOM   4064 C CD2 . PHE C 3 28  ? 243.771 274.803 353.365 1.00 7.19  ? 28  PHE C CD2 1 
ATOM   4065 C CE1 . PHE C 3 28  ? 245.083 274.839 355.789 1.00 7.68  ? 28  PHE C CE1 1 
ATOM   4066 C CE2 . PHE C 3 28  ? 243.381 273.941 354.372 1.00 8.34  ? 28  PHE C CE2 1 
ATOM   4067 C CZ  . PHE C 3 28  ? 244.037 273.958 355.585 1.00 6.38  ? 28  PHE C CZ  1 
ATOM   4068 N N   . ASP C 3 29  ? 246.395 273.680 351.161 1.00 11.36 ? 29  ASP C N   1 
ATOM   4069 C CA  . ASP C 3 29  ? 246.024 272.399 350.557 1.00 8.97  ? 29  ASP C CA  1 
ATOM   4070 C C   . ASP C 3 29  ? 244.776 271.881 351.267 1.00 3.01  ? 29  ASP C C   1 
ATOM   4071 O O   . ASP C 3 29  ? 244.850 271.174 352.270 1.00 13.90 ? 29  ASP C O   1 
ATOM   4072 C CB  . ASP C 3 29  ? 247.179 271.410 350.651 1.00 6.71  ? 29  ASP C CB  1 
ATOM   4073 C CG  . ASP C 3 29  ? 246.895 270.110 349.927 1.00 17.19 ? 29  ASP C CG  1 
ATOM   4074 O OD1 . ASP C 3 29  ? 246.046 270.103 349.014 1.00 22.65 ? 29  ASP C OD1 1 
ATOM   4075 O OD2 . ASP C 3 29  ? 247.516 269.087 350.280 1.00 25.21 ? 29  ASP C OD2 1 
ATOM   4076 N N   . VAL C 3 30  ? 243.609 272.233 350.726 1.00 7.15  ? 30  VAL C N   1 
ATOM   4077 C CA  . VAL C 3 30  ? 242.340 271.917 351.376 1.00 10.11 ? 30  VAL C CA  1 
ATOM   4078 C C   . VAL C 3 30  ? 242.128 270.409 351.425 1.00 4.32  ? 30  VAL C C   1 
ATOM   4079 O O   . VAL C 3 30  ? 242.381 269.693 350.448 1.00 5.97  ? 30  VAL C O   1 
ATOM   4080 C CB  . VAL C 3 30  ? 241.182 272.610 350.635 1.00 8.61  ? 30  VAL C CB  1 
ATOM   4081 C CG1 . VAL C 3 30  ? 239.850 272.240 351.260 1.00 15.67 ? 30  VAL C CG1 1 
ATOM   4082 C CG2 . VAL C 3 30  ? 241.375 274.122 350.636 1.00 8.56  ? 30  VAL C CG2 1 
ATOM   4083 N N   . THR C 3 31  ? 241.643 269.920 352.563 1.00 10.43 ? 31  THR C N   1 
ATOM   4084 C CA  . THR C 3 31  ? 241.271 268.515 352.671 1.00 10.14 ? 31  THR C CA  1 
ATOM   4085 C C   . THR C 3 31  ? 240.120 268.227 351.710 1.00 5.15  ? 31  THR C C   1 
ATOM   4086 O O   . THR C 3 31  ? 239.095 268.920 351.758 1.00 13.70 ? 31  THR C O   1 
ATOM   4087 C CB  . THR C 3 31  ? 240.861 268.165 354.104 1.00 10.13 ? 31  THR C CB  1 
ATOM   4088 O OG1 . THR C 3 31  ? 242.005 268.218 354.962 1.00 14.71 ? 31  THR C OG1 1 
ATOM   4089 C CG2 . THR C 3 31  ? 240.241 266.771 354.176 1.00 7.60  ? 31  THR C CG2 1 
ATOM   4090 N N   . PRO C 3 32  ? 240.245 267.241 350.828 1.00 6.38  ? 32  PRO C N   1 
ATOM   4091 C CA  . PRO C 3 32  ? 239.188 266.988 349.842 1.00 10.99 ? 32  PRO C CA  1 
ATOM   4092 C C   . PRO C 3 32  ? 237.941 266.430 350.502 1.00 8.64  ? 32  PRO C C   1 
ATOM   4093 O O   . PRO C 3 32  ? 238.015 265.827 351.583 1.00 11.07 ? 32  PRO C O   1 
ATOM   4094 C CB  . PRO C 3 32  ? 239.826 265.963 348.895 1.00 11.28 ? 32  PRO C CB  1 
ATOM   4095 C CG  . PRO C 3 32  ? 240.829 265.266 349.729 1.00 14.38 ? 32  PRO C CG  1 
ATOM   4096 C CD  . PRO C 3 32  ? 241.353 266.279 350.701 1.00 8.46  ? 32  PRO C CD  1 
ATOM   4097 N N   . PRO C 3 33  ? 236.774 266.616 349.891 1.00 11.42 ? 33  PRO C N   1 
ATOM   4098 C CA  . PRO C 3 33  ? 235.546 266.066 350.469 1.00 9.98  ? 33  PRO C CA  1 
ATOM   4099 C C   . PRO C 3 33  ? 235.448 264.561 350.271 1.00 9.94  ? 33  PRO C C   1 
ATOM   4100 O O   . PRO C 3 33  ? 236.079 263.970 349.393 1.00 12.90 ? 33  PRO C O   1 
ATOM   4101 C CB  . PRO C 3 33  ? 234.438 266.799 349.706 1.00 9.38  ? 33  PRO C CB  1 
ATOM   4102 C CG  . PRO C 3 33  ? 235.049 267.117 348.389 1.00 8.81  ? 33  PRO C CG  1 
ATOM   4103 C CD  . PRO C 3 33  ? 236.509 267.372 348.654 1.00 12.83 ? 33  PRO C CD  1 
ATOM   4104 N N   . ILE C 3 34  ? 234.637 263.940 351.123 1.00 11.89 ? 34  ILE C N   1 
ATOM   4105 C CA  . ILE C 3 34  ? 234.257 262.544 350.975 1.00 9.40  ? 34  ILE C CA  1 
ATOM   4106 C C   . ILE C 3 34  ? 232.752 262.493 350.758 1.00 6.21  ? 34  ILE C C   1 
ATOM   4107 O O   . ILE C 3 34  ? 232.026 263.454 351.025 1.00 14.61 ? 34  ILE C O   1 
ATOM   4108 C CB  . ILE C 3 34  ? 234.669 261.678 352.187 1.00 8.96  ? 34  ILE C CB  1 
ATOM   4109 C CG1 . ILE C 3 34  ? 234.129 262.280 353.489 1.00 10.16 ? 34  ILE C CG1 1 
ATOM   4110 C CG2 . ILE C 3 34  ? 236.182 261.522 352.230 1.00 14.01 ? 34  ILE C CG2 1 
ATOM   4111 C CD1 . ILE C 3 34  ? 234.421 261.450 354.726 1.00 10.05 ? 34  ILE C CD1 1 
ATOM   4112 N N   . ASP C 3 35  ? 232.285 261.350 350.260 1.00 18.66 ? 35  ASP C N   1 
ATOM   4113 C CA  . ASP C 3 35  ? 230.872 261.166 349.933 1.00 8.28  ? 35  ASP C CA  1 
ATOM   4114 C C   . ASP C 3 35  ? 230.101 260.796 351.202 1.00 9.00  ? 35  ASP C C   1 
ATOM   4115 O O   . ASP C 3 35  ? 229.705 259.652 351.428 1.00 14.05 ? 35  ASP C O   1 
ATOM   4116 C CB  . ASP C 3 35  ? 230.712 260.107 348.852 1.00 11.94 ? 35  ASP C CB  1 
ATOM   4117 C CG  . ASP C 3 35  ? 229.299 260.035 348.310 1.00 16.07 ? 35  ASP C CG  1 
ATOM   4118 O OD1 . ASP C 3 35  ? 228.497 260.948 348.601 1.00 20.55 ? 35  ASP C OD1 1 
ATOM   4119 O OD2 . ASP C 3 35  ? 228.989 259.062 347.596 1.00 20.76 ? 35  ASP C OD2 1 
ATOM   4120 N N   . ILE C 3 36  ? 229.900 261.800 352.045 1.00 6.78  ? 36  ILE C N   1 
ATOM   4121 C CA  . ILE C 3 36  ? 229.091 261.609 353.254 1.00 5.14  ? 36  ILE C CA  1 
ATOM   4122 C C   . ILE C 3 36  ? 227.642 261.358 352.850 1.00 7.27  ? 36  ILE C C   1 
ATOM   4123 O O   . ILE C 3 36  ? 227.142 262.020 351.925 1.00 11.82 ? 36  ILE C O   1 
ATOM   4124 C CB  . ILE C 3 36  ? 229.204 262.832 354.169 1.00 1.95  ? 36  ILE C CB  1 
ATOM   4125 C CG1 . ILE C 3 36  ? 230.669 263.089 354.538 1.00 10.76 ? 36  ILE C CG1 1 
ATOM   4126 C CG2 . ILE C 3 36  ? 228.353 262.645 355.425 1.00 1.80  ? 36  ILE C CG2 1 
ATOM   4127 C CD1 . ILE C 3 36  ? 230.884 264.325 355.370 1.00 5.33  ? 36  ILE C CD1 1 
ATOM   4128 N N   . PRO C 3 37  ? 226.936 260.425 353.484 1.00 4.70  ? 37  PRO C N   1 
ATOM   4129 C CA  . PRO C 3 37  ? 225.510 260.256 353.185 1.00 7.00  ? 37  PRO C CA  1 
ATOM   4130 C C   . PRO C 3 37  ? 224.693 261.456 353.640 1.00 3.66  ? 37  PRO C C   1 
ATOM   4131 O O   . PRO C 3 37  ? 225.109 262.250 354.485 1.00 9.67  ? 37  PRO C O   1 
ATOM   4132 C CB  . PRO C 3 37  ? 225.123 258.995 353.969 1.00 3.73  ? 37  PRO C CB  1 
ATOM   4133 C CG  . PRO C 3 37  ? 226.402 258.279 354.199 1.00 9.86  ? 37  PRO C CG  1 
ATOM   4134 C CD  . PRO C 3 37  ? 227.433 259.352 354.362 1.00 6.05  ? 37  PRO C CD  1 
ATOM   4135 N N   . GLY C 3 38  ? 223.511 261.579 353.048 1.00 4.65  ? 38  GLY C N   1 
ATOM   4136 C CA  . GLY C 3 38  ? 222.547 262.584 353.463 1.00 5.11  ? 38  GLY C CA  1 
ATOM   4137 C C   . GLY C 3 38  ? 222.943 264.023 353.207 1.00 6.12  ? 38  GLY C C   1 
ATOM   4138 O O   . GLY C 3 38  ? 222.740 264.877 354.078 1.00 6.51  ? 38  GLY C O   1 
ATOM   4139 N N   . GLU C 3 39  ? 223.497 264.320 352.034 1.00 9.41  ? 39  GLU C N   1 
ATOM   4140 C CA  . GLU C 3 39  ? 223.778 265.704 351.679 1.00 5.41  ? 39  GLU C CA  1 
ATOM   4141 C C   . GLU C 3 39  ? 222.481 266.448 351.375 1.00 2.10  ? 39  GLU C C   1 
ATOM   4142 O O   . GLU C 3 39  ? 221.539 265.883 350.813 1.00 12.37 ? 39  GLU C O   1 
ATOM   4143 C CB  . GLU C 3 39  ? 224.715 265.778 350.473 1.00 1.34  ? 39  GLU C CB  1 
ATOM   4144 C CG  . GLU C 3 39  ? 225.132 267.205 350.134 1.00 10.88 ? 39  GLU C CG  1 
ATOM   4145 C CD  . GLU C 3 39  ? 226.234 267.281 349.093 1.00 13.14 ? 39  GLU C CD  1 
ATOM   4146 O OE1 . GLU C 3 39  ? 226.741 266.223 348.671 1.00 21.35 ? 39  GLU C OE1 1 
ATOM   4147 O OE2 . GLU C 3 39  ? 226.590 268.407 348.694 1.00 11.72 ? 39  GLU C OE2 1 
ATOM   4148 N N   . VAL C 3 40  ? 222.439 267.724 351.750 1.00 0.01  ? 40  VAL C N   1 
ATOM   4149 C CA  . VAL C 3 40  ? 221.276 268.583 351.550 1.00 10.62 ? 40  VAL C CA  1 
ATOM   4150 C C   . VAL C 3 40  ? 221.684 269.750 350.661 1.00 3.51  ? 40  VAL C C   1 
ATOM   4151 O O   . VAL C 3 40  ? 222.638 270.469 350.975 1.00 10.23 ? 40  VAL C O   1 
ATOM   4152 C CB  . VAL C 3 40  ? 220.713 269.091 352.891 1.00 8.56  ? 40  VAL C CB  1 
ATOM   4153 C CG1 . VAL C 3 40  ? 219.625 270.133 352.661 1.00 4.40  ? 40  VAL C CG1 1 
ATOM   4154 C CG2 . VAL C 3 40  ? 220.181 267.934 353.716 1.00 5.76  ? 40  VAL C CG2 1 
ATOM   4155 N N   . ARG C 3 41  ? 220.952 269.944 349.564 1.00 10.85 ? 41  ARG C N   1 
ATOM   4156 C CA  . ARG C 3 41  ? 221.212 271.043 348.639 1.00 8.20  ? 41  ARG C CA  1 
ATOM   4157 C C   . ARG C 3 41  ? 220.290 272.235 348.844 1.00 6.86  ? 41  ARG C C   1 
ATOM   4158 O O   . ARG C 3 41  ? 220.678 273.363 348.531 1.00 16.47 ? 41  ARG C O   1 
ATOM   4159 C CB  . ARG C 3 41  ? 221.062 270.569 347.190 1.00 8.28  ? 41  ARG C CB  1 
ATOM   4160 C CG  . ARG C 3 41  ? 221.787 269.281 346.868 1.00 13.59 ? 41  ARG C CG  1 
ATOM   4161 C CD  . ARG C 3 41  ? 223.286 269.464 346.846 1.00 12.66 ? 41  ARG C CD  1 
ATOM   4162 N NE  . ARG C 3 41  ? 223.976 268.182 346.906 1.00 25.81 ? 41  ARG C NE  1 
ATOM   4163 C CZ  . ARG C 3 41  ? 224.009 267.303 345.914 1.00 20.66 ? 41  ARG C CZ  1 
ATOM   4164 N NH1 . ARG C 3 41  ? 223.396 267.533 344.764 1.00 23.76 ? 41  ARG C NH1 1 
ATOM   4165 N NH2 . ARG C 3 41  ? 224.667 266.160 346.082 1.00 16.41 ? 41  ARG C NH2 1 
ATOM   4166 N N   . ASN C 3 42  ? 219.084 272.013 349.360 1.00 8.42  ? 42  ASN C N   1 
ATOM   4167 C CA  . ASN C 3 42  ? 218.078 273.059 349.455 1.00 10.49 ? 42  ASN C CA  1 
ATOM   4168 C C   . ASN C 3 42  ? 217.294 272.866 350.744 1.00 5.43  ? 42  ASN C C   1 
ATOM   4169 O O   . ASN C 3 42  ? 216.929 271.741 351.090 1.00 13.39 ? 42  ASN C O   1 
ATOM   4170 C CB  . ASN C 3 42  ? 217.138 273.022 348.241 1.00 7.31  ? 42  ASN C CB  1 
ATOM   4171 C CG  . ASN C 3 42  ? 216.374 274.317 348.049 1.00 7.85  ? 42  ASN C CG  1 
ATOM   4172 O OD1 . ASN C 3 42  ? 215.511 274.664 348.850 1.00 11.06 ? 42  ASN C OD1 1 
ATOM   4173 N ND2 . ASN C 3 42  ? 216.679 275.030 346.974 1.00 7.70  ? 42  ASN C ND2 1 
ATOM   4174 N N   . MET C 3 43  ? 217.025 273.971 351.441 1.00 11.58 ? 43  MET C N   1 
ATOM   4175 C CA  . MET C 3 43  ? 216.295 273.889 352.703 1.00 7.68  ? 43  MET C CA  1 
ATOM   4176 C C   . MET C 3 43  ? 214.905 273.292 352.513 1.00 9.05  ? 43  MET C C   1 
ATOM   4177 O O   . MET C 3 43  ? 214.364 272.676 353.437 1.00 12.82 ? 43  MET C O   1 
ATOM   4178 C CB  . MET C 3 43  ? 216.191 275.273 353.343 1.00 4.28  ? 43  MET C CB  1 
ATOM   4179 C CG  . MET C 3 43  ? 217.525 275.988 353.525 1.00 10.05 ? 43  MET C CG  1 
ATOM   4180 S SD  . MET C 3 43  ? 218.759 275.017 354.410 1.00 15.90 ? 43  MET C SD  1 
ATOM   4181 C CE  . MET C 3 43  ? 218.047 274.956 356.049 1.00 2.13  ? 43  MET C CE  1 
ATOM   4182 N N   . MET C 3 44  ? 214.312 273.457 351.327 1.00 6.85  ? 44  MET C N   1 
ATOM   4183 C CA  . MET C 3 44  ? 213.002 272.870 351.071 1.00 14.46 ? 44  MET C CA  1 
ATOM   4184 C C   . MET C 3 44  ? 213.015 271.355 351.214 1.00 10.58 ? 44  MET C C   1 
ATOM   4185 O O   . MET C 3 44  ? 211.988 270.771 351.573 1.00 15.28 ? 44  MET C O   1 
ATOM   4186 C CB  . MET C 3 44  ? 212.512 273.257 349.675 1.00 7.39  ? 44  MET C CB  1 
ATOM   4187 C CG  . MET C 3 44  ? 212.138 274.723 349.528 1.00 8.70  ? 44  MET C CG  1 
ATOM   4188 S SD  . MET C 3 44  ? 210.651 275.180 350.443 1.00 27.35 ? 44  MET C SD  1 
ATOM   4189 C CE  . MET C 3 44  ? 211.311 275.581 352.054 1.00 14.04 ? 44  MET C CE  1 
ATOM   4190 N N   . GLU C 3 45  ? 214.155 270.708 350.958 1.00 10.40 ? 45  GLU C N   1 
ATOM   4191 C CA  . GLU C 3 45  ? 214.257 269.273 351.205 1.00 6.42  ? 45  GLU C CA  1 
ATOM   4192 C C   . GLU C 3 45  ? 213.881 268.945 352.641 1.00 7.11  ? 45  GLU C C   1 
ATOM   4193 O O   . GLU C 3 45  ? 213.175 267.965 352.899 1.00 15.22 ? 45  GLU C O   1 
ATOM   4194 C CB  . GLU C 3 45  ? 215.674 268.783 350.912 1.00 9.78  ? 45  GLU C CB  1 
ATOM   4195 C CG  . GLU C 3 45  ? 216.134 268.987 349.485 1.00 14.57 ? 45  GLU C CG  1 
ATOM   4196 C CD  . GLU C 3 45  ? 217.605 268.669 349.310 1.00 13.66 ? 45  GLU C CD  1 
ATOM   4197 O OE1 . GLU C 3 45  ? 218.079 267.694 349.927 1.00 25.06 ? 45  GLU C OE1 1 
ATOM   4198 O OE2 . GLU C 3 45  ? 218.290 269.397 348.565 1.00 18.28 ? 45  GLU C OE2 1 
ATOM   4199 N N   . LEU C 3 46  ? 214.347 269.755 353.592 1.00 6.14  ? 46  LEU C N   1 
ATOM   4200 C CA  . LEU C 3 46  ? 213.965 269.554 354.983 1.00 9.22  ? 46  LEU C CA  1 
ATOM   4201 C C   . LEU C 3 46  ? 212.478 269.815 355.181 1.00 9.94  ? 46  LEU C C   1 
ATOM   4202 O O   . LEU C 3 46  ? 211.812 269.104 355.942 1.00 17.84 ? 46  LEU C O   1 
ATOM   4203 C CB  . LEU C 3 46  ? 214.799 270.456 355.894 1.00 7.51  ? 46  LEU C CB  1 
ATOM   4204 C CG  . LEU C 3 46  ? 216.231 270.008 356.203 1.00 9.08  ? 46  LEU C CG  1 
ATOM   4205 C CD1 . LEU C 3 46  ? 216.991 269.639 354.946 1.00 11.74 ? 46  LEU C CD1 1 
ATOM   4206 C CD2 . LEU C 3 46  ? 216.963 271.097 356.967 1.00 7.95  ? 46  LEU C CD2 1 
ATOM   4207 N N   . ALA C 3 47  ? 211.938 270.827 354.497 1.00 8.25  ? 47  ALA C N   1 
ATOM   4208 C CA  . ALA C 3 47  ? 210.525 271.152 354.640 1.00 14.11 ? 47  ALA C CA  1 
ATOM   4209 C C   . ALA C 3 47  ? 209.625 270.077 354.049 1.00 6.93  ? 47  ALA C C   1 
ATOM   4210 O O   . ALA C 3 47  ? 208.469 269.959 354.464 1.00 10.85 ? 47  ALA C O   1 
ATOM   4211 C CB  . ALA C 3 47  ? 210.229 272.501 353.984 1.00 9.04  ? 47  ALA C CB  1 
ATOM   4212 N N   . GLU C 3 48  ? 210.127 269.285 353.106 1.00 7.14  ? 48  GLU C N   1 
ATOM   4213 C CA  . GLU C 3 48  ? 209.338 268.223 352.499 1.00 7.87  ? 48  GLU C CA  1 
ATOM   4214 C C   . GLU C 3 48  ? 209.306 266.954 353.343 1.00 11.27 ? 48  GLU C C   1 
ATOM   4215 O O   . GLU C 3 48  ? 208.642 265.990 352.954 1.00 16.09 ? 48  GLU C O   1 
ATOM   4216 C CB  . GLU C 3 48  ? 209.876 267.907 351.101 1.00 7.43  ? 48  GLU C CB  1 
ATOM   4217 C CG  . GLU C 3 48  ? 209.625 269.014 350.086 1.00 11.47 ? 48  GLU C CG  1 
ATOM   4218 C CD  . GLU C 3 48  ? 210.231 268.717 348.727 1.00 18.02 ? 48  GLU C CD  1 
ATOM   4219 O OE1 . GLU C 3 48  ? 210.947 267.703 348.600 1.00 28.34 ? 48  GLU C OE1 1 
ATOM   4220 O OE2 . GLU C 3 48  ? 209.989 269.495 347.782 1.00 17.82 ? 48  GLU C OE2 1 
ATOM   4221 N N   . ILE C 3 49  ? 209.998 266.932 354.477 1.00 9.62  ? 49  ILE C N   1 
ATOM   4222 C CA  . ILE C 3 49  ? 209.999 265.780 355.371 1.00 11.89 ? 49  ILE C CA  1 
ATOM   4223 C C   . ILE C 3 49  ? 208.858 265.932 356.367 1.00 9.51  ? 49  ILE C C   1 
ATOM   4224 O O   . ILE C 3 49  ? 208.714 266.981 357.005 1.00 13.16 ? 49  ILE C O   1 
ATOM   4225 C CB  . ILE C 3 49  ? 211.348 265.648 356.098 1.00 11.22 ? 49  ILE C CB  1 
ATOM   4226 C CG1 . ILE C 3 49  ? 212.479 265.430 355.089 1.00 10.39 ? 49  ILE C CG1 1 
ATOM   4227 C CG2 . ILE C 3 49  ? 211.291 264.511 357.113 1.00 7.13  ? 49  ILE C CG2 1 
ATOM   4228 C CD1 . ILE C 3 49  ? 213.859 265.600 355.671 1.00 13.10 ? 49  ILE C CD1 1 
ATOM   4229 N N   . ASP C 3 50  ? 208.041 264.891 356.493 1.00 5.97  ? 50  ASP C N   1 
ATOM   4230 C CA  . ASP C 3 50  ? 206.950 264.904 357.460 1.00 7.98  ? 50  ASP C CA  1 
ATOM   4231 C C   . ASP C 3 50  ? 207.500 264.943 358.880 1.00 8.41  ? 50  ASP C C   1 
ATOM   4232 O O   . ASP C 3 50  ? 208.355 264.134 359.249 1.00 20.23 ? 50  ASP C O   1 
ATOM   4233 C CB  . ASP C 3 50  ? 206.063 263.675 357.271 1.00 5.88  ? 50  ASP C CB  1 
ATOM   4234 C CG  . ASP C 3 50  ? 205.089 263.829 356.121 1.00 18.53 ? 50  ASP C CG  1 
ATOM   4235 O OD1 . ASP C 3 50  ? 204.386 264.859 356.070 1.00 22.09 ? 50  ASP C OD1 1 
ATOM   4236 O OD2 . ASP C 3 50  ? 205.027 262.922 355.266 1.00 25.63 ? 50  ASP C OD2 1 
ATOM   4237 N N   . THR C 3 51  ? 207.005 265.886 359.678 1.00 5.72  ? 51  THR C N   1 
ATOM   4238 C CA  . THR C 3 51  ? 207.356 265.986 361.086 1.00 6.90  ? 51  THR C CA  1 
ATOM   4239 C C   . THR C 3 51  ? 206.081 266.119 361.906 1.00 1.95  ? 51  THR C C   1 
ATOM   4240 O O   . THR C 3 51  ? 205.060 266.606 361.420 1.00 12.32 ? 51  THR C O   1 
ATOM   4241 C CB  . THR C 3 51  ? 208.299 267.174 361.372 1.00 7.61  ? 51  THR C CB  1 
ATOM   4242 O OG1 . THR C 3 51  ? 207.648 268.409 361.050 1.00 10.62 ? 51  THR C OG1 1 
ATOM   4243 C CG2 . THR C 3 51  ? 209.581 267.045 360.560 1.00 11.60 ? 51  THR C CG2 1 
ATOM   4244 N N   . MET C 3 52  ? 206.155 265.676 363.157 1.00 3.33  ? 52  MET C N   1 
ATOM   4245 C CA  . MET C 3 52  ? 204.962 265.532 363.979 1.00 6.00  ? 52  MET C CA  1 
ATOM   4246 C C   . MET C 3 52  ? 204.452 266.891 364.445 1.00 7.39  ? 52  MET C C   1 
ATOM   4247 O O   . MET C 3 52  ? 205.229 267.748 364.874 1.00 14.31 ? 52  MET C O   1 
ATOM   4248 C CB  . MET C 3 52  ? 205.268 264.636 365.176 1.00 6.94  ? 52  MET C CB  1 
ATOM   4249 C CG  . MET C 3 52  ? 204.053 263.963 365.783 1.00 13.92 ? 52  MET C CG  1 
ATOM   4250 S SD  . MET C 3 52  ? 204.478 262.465 366.694 1.00 21.71 ? 52  MET C SD  1 
ATOM   4251 C CE  . MET C 3 52  ? 205.606 263.110 367.926 1.00 8.95  ? 52  MET C CE  1 
ATOM   4252 N N   . ILE C 3 53  ? 203.139 267.078 364.370 1.00 9.12  ? 53  ILE C N   1 
ATOM   4253 C CA  . ILE C 3 53  ? 202.497 268.337 364.738 1.00 4.72  ? 53  ILE C CA  1 
ATOM   4254 C C   . ILE C 3 53  ? 202.158 268.309 366.225 1.00 6.06  ? 53  ILE C C   1 
ATOM   4255 O O   . ILE C 3 53  ? 201.527 267.351 366.691 1.00 11.32 ? 53  ILE C O   1 
ATOM   4256 C CB  . ILE C 3 53  ? 201.228 268.582 363.904 1.00 12.01 ? 53  ILE C CB  1 
ATOM   4257 C CG1 . ILE C 3 53  ? 201.527 268.484 362.405 1.00 9.79  ? 53  ILE C CG1 1 
ATOM   4258 C CG2 . ILE C 3 53  ? 200.621 269.941 364.240 1.00 8.36  ? 53  ILE C CG2 1 
ATOM   4259 C CD1 . ILE C 3 53  ? 200.286 268.341 361.555 1.00 6.58  ? 53  ILE C CD1 1 
ATOM   4260 N N   . PRO C 3 54  ? 202.554 269.316 367.011 1.00 11.92 ? 54  PRO C N   1 
ATOM   4261 C CA  . PRO C 3 54  ? 202.015 269.424 368.386 1.00 9.20  ? 54  PRO C CA  1 
ATOM   4262 C C   . PRO C 3 54  ? 200.569 269.914 368.364 1.00 8.03  ? 54  PRO C C   1 
ATOM   4263 O O   . PRO C 3 54  ? 200.246 271.075 368.601 1.00 16.97 ? 54  PRO C O   1 
ATOM   4264 C CB  . PRO C 3 54  ? 202.968 270.425 369.044 1.00 10.73 ? 54  PRO C CB  1 
ATOM   4265 C CG  . PRO C 3 54  ? 203.473 271.254 367.919 1.00 6.21  ? 54  PRO C CG  1 
ATOM   4266 C CD  . PRO C 3 54  ? 203.597 270.323 366.754 1.00 6.87  ? 54  PRO C CD  1 
ATOM   4267 N N   . LEU C 3 55  ? 199.663 268.986 368.052 1.00 15.12 ? 55  LEU C N   1 
ATOM   4268 C CA  . LEU C 3 55  ? 198.260 269.331 367.855 1.00 10.16 ? 55  LEU C CA  1 
ATOM   4269 C C   . LEU C 3 55  ? 197.552 269.699 369.151 1.00 7.22  ? 55  LEU C C   1 
ATOM   4270 O O   . LEU C 3 55  ? 196.595 270.477 369.117 1.00 16.39 ? 55  LEU C O   1 
ATOM   4271 C CB  . LEU C 3 55  ? 197.529 268.162 367.193 1.00 9.76  ? 55  LEU C CB  1 
ATOM   4272 C CG  . LEU C 3 55  ? 197.899 267.871 365.739 1.00 9.83  ? 55  LEU C CG  1 
ATOM   4273 C CD1 . LEU C 3 55  ? 197.444 266.478 365.350 1.00 14.32 ? 55  LEU C CD1 1 
ATOM   4274 C CD2 . LEU C 3 55  ? 197.298 268.911 364.810 1.00 11.15 ? 55  LEU C CD2 1 
ATOM   4275 N N   . ASN C 3 56  ? 197.996 269.166 370.286 1.00 10.99 ? 56  ASN C N   1 
ATOM   4276 C CA  . ASN C 3 56  ? 197.273 269.281 371.548 1.00 8.73  ? 56  ASN C CA  1 
ATOM   4277 C C   . ASN C 3 56  ? 198.081 270.168 372.492 1.00 7.08  ? 56  ASN C C   1 
ATOM   4278 O O   . ASN C 3 56  ? 198.790 269.690 373.377 1.00 20.39 ? 56  ASN C O   1 
ATOM   4279 C CB  . ASN C 3 56  ? 197.045 267.872 372.132 1.00 13.10 ? 56  ASN C CB  1 
ATOM   4280 C CG  . ASN C 3 56  ? 195.663 267.693 372.720 1.00 10.55 ? 56  ASN C CG  1 
ATOM   4281 O OD1 . ASN C 3 56  ? 195.050 268.641 373.204 1.00 22.83 ? 56  ASN C OD1 1 
ATOM   4282 N ND2 . ASN C 3 56  ? 195.165 266.467 372.682 1.00 17.79 ? 56  ASN C ND2 1 
ATOM   4283 N N   . LEU C 3 57  ? 197.946 271.478 372.316 1.00 18.39 ? 57  LEU C N   1 
ATOM   4284 C CA  . LEU C 3 57  ? 198.657 272.443 373.154 1.00 12.87 ? 57  LEU C CA  1 
ATOM   4285 C C   . LEU C 3 57  ? 197.787 272.935 374.306 1.00 12.79 ? 57  LEU C C   1 
ATOM   4286 O O   . LEU C 3 57  ? 197.638 274.133 374.528 1.00 19.66 ? 57  LEU C O   1 
ATOM   4287 C CB  . LEU C 3 57  ? 199.150 273.606 372.302 1.00 10.78 ? 57  LEU C CB  1 
ATOM   4288 C CG  . LEU C 3 57  ? 200.179 273.249 371.226 1.00 14.15 ? 57  LEU C CG  1 
ATOM   4289 C CD1 . LEU C 3 57  ? 200.490 274.453 370.351 1.00 12.20 ? 57  LEU C CD1 1 
ATOM   4290 C CD2 . LEU C 3 57  ? 201.451 272.698 371.854 1.00 14.64 ? 57  LEU C CD2 1 
ATOM   4291 N N   . THR C 3 58  ? 197.214 272.003 375.060 1.00 15.19 ? 58  THR C N   1 
ATOM   4292 C CA  . THR C 3 58  ? 196.464 272.374 376.246 1.00 16.81 ? 58  THR C CA  1 
ATOM   4293 C C   . THR C 3 58  ? 197.427 272.710 377.380 1.00 17.10 ? 58  THR C C   1 
ATOM   4294 O O   . THR C 3 58  ? 198.638 272.493 377.293 1.00 18.44 ? 58  THR C O   1 
ATOM   4295 C CB  . THR C 3 58  ? 195.522 271.250 376.674 1.00 16.00 ? 58  THR C CB  1 
ATOM   4296 O OG1 . THR C 3 58  ? 196.284 270.109 377.085 1.00 21.83 ? 58  THR C OG1 1 
ATOM   4297 C CG2 . THR C 3 58  ? 194.601 270.859 375.533 1.00 19.05 ? 58  THR C CG2 1 
ATOM   4298 N N   . ASN C 3 59  ? 196.870 273.241 378.467 1.00 16.86 ? 59  ASN C N   1 
ATOM   4299 C CA  . ASN C 3 59  ? 197.706 273.626 379.596 1.00 19.59 ? 59  ASN C CA  1 
ATOM   4300 C C   . ASN C 3 59  ? 198.480 272.432 380.140 1.00 20.11 ? 59  ASN C C   1 
ATOM   4301 O O   . ASN C 3 59  ? 199.658 272.555 380.491 1.00 24.83 ? 59  ASN C O   1 
ATOM   4302 C CB  . ASN C 3 59  ? 196.851 274.249 380.695 1.00 21.48 ? 59  ASN C CB  1 
ATOM   4303 C CG  . ASN C 3 59  ? 197.652 274.568 381.935 1.00 22.11 ? 59  ASN C CG  1 
ATOM   4304 O OD1 . ASN C 3 59  ? 198.369 275.566 381.984 1.00 25.58 ? 59  ASN C OD1 1 
ATOM   4305 N ND2 . ASN C 3 59  ? 197.540 273.717 382.947 1.00 25.49 ? 59  ASN C ND2 1 
ATOM   4306 N N   . GLN C 3 60  ? 197.837 271.270 380.218 1.00 20.90 ? 60  GLN C N   1 
ATOM   4307 C CA  . GLN C 3 60  ? 198.463 270.093 380.802 1.00 19.14 ? 60  GLN C CA  1 
ATOM   4308 C C   . GLN C 3 60  ? 199.276 269.280 379.803 1.00 17.49 ? 60  GLN C C   1 
ATOM   4309 O O   . GLN C 3 60  ? 200.017 268.384 380.220 1.00 27.65 ? 60  GLN C O   1 
ATOM   4310 C CB  . GLN C 3 60  ? 197.394 269.197 381.434 1.00 20.80 ? 60  GLN C CB  1 
ATOM   4311 C CG  . GLN C 3 60  ? 196.634 269.866 382.568 1.00 21.99 ? 60  GLN C CG  1 
ATOM   4312 C CD  . GLN C 3 60  ? 195.628 268.943 383.228 1.00 28.83 ? 60  GLN C CD  1 
ATOM   4313 O OE1 . GLN C 3 60  ? 194.889 268.226 382.554 1.00 28.96 ? 60  GLN C OE1 1 
ATOM   4314 N NE2 . GLN C 3 60  ? 195.599 268.955 384.555 1.00 27.65 ? 60  GLN C NE2 1 
ATOM   4315 N N   . ARG C 3 61  ? 199.170 269.570 378.508 1.00 16.06 ? 61  ARG C N   1 
ATOM   4316 C CA  . ARG C 3 61  ? 199.869 268.802 377.486 1.00 15.72 ? 61  ARG C CA  1 
ATOM   4317 C C   . ARG C 3 61  ? 201.014 269.550 376.825 1.00 15.96 ? 61  ARG C C   1 
ATOM   4318 O O   . ARG C 3 61  ? 201.976 268.912 376.396 1.00 19.07 ? 61  ARG C O   1 
ATOM   4319 C CB  . ARG C 3 61  ? 198.893 268.355 376.391 1.00 15.66 ? 61  ARG C CB  1 
ATOM   4320 C CG  . ARG C 3 61  ? 197.914 267.283 376.824 1.00 14.86 ? 61  ARG C CG  1 
ATOM   4321 C CD  . ARG C 3 61  ? 196.989 266.906 375.683 1.00 14.03 ? 61  ARG C CD  1 
ATOM   4322 N NE  . ARG C 3 61  ? 196.072 265.834 376.049 1.00 19.67 ? 61  ARG C NE  1 
ATOM   4323 C CZ  . ARG C 3 61  ? 196.250 264.549 375.767 1.00 16.06 ? 61  ARG C CZ  1 
ATOM   4324 N NH1 . ARG C 3 61  ? 197.307 264.125 375.094 1.00 12.63 ? 61  ARG C NH1 1 
ATOM   4325 N NH2 . ARG C 3 61  ? 195.341 263.667 376.170 1.00 20.49 ? 61  ARG C NH2 1 
ATOM   4326 N N   . LYS C 3 62  ? 200.938 270.874 376.728 1.00 12.56 ? 62  LYS C N   1 
ATOM   4327 C CA  . LYS C 3 62  ? 201.953 271.619 375.997 1.00 15.50 ? 62  LYS C CA  1 
ATOM   4328 C C   . LYS C 3 62  ? 203.324 271.410 376.625 1.00 10.04 ? 62  LYS C C   1 
ATOM   4329 O O   . LYS C 3 62  ? 203.466 271.349 377.848 1.00 11.18 ? 62  LYS C O   1 
ATOM   4330 C CB  . LYS C 3 62  ? 201.603 273.108 375.966 1.00 16.18 ? 62  LYS C CB  1 
ATOM   4331 C CG  . LYS C 3 62  ? 201.646 273.798 377.317 1.00 14.67 ? 62  LYS C CG  1 
ATOM   4332 C CD  . LYS C 3 62  ? 201.029 275.184 377.240 1.00 15.85 ? 62  LYS C CD  1 
ATOM   4333 C CE  . LYS C 3 62  ? 201.158 275.930 378.556 1.00 17.07 ? 62  LYS C CE  1 
ATOM   4334 N NZ  . LYS C 3 62  ? 202.560 276.325 378.839 1.00 19.07 ? 62  LYS C NZ  1 
ATOM   4335 N N   . ASN C 3 63  ? 204.337 271.285 375.769 1.00 8.05  ? 63  ASN C N   1 
ATOM   4336 C CA  . ASN C 3 63  ? 205.716 271.068 376.203 1.00 14.67 ? 63  ASN C CA  1 
ATOM   4337 C C   . ASN C 3 63  ? 205.880 269.727 376.912 1.00 13.04 ? 63  ASN C C   1 
ATOM   4338 O O   . ASN C 3 63  ? 206.708 269.584 377.812 1.00 16.24 ? 63  ASN C O   1 
ATOM   4339 C CB  . ASN C 3 63  ? 206.193 272.219 377.091 1.00 10.50 ? 63  ASN C CB  1 
ATOM   4340 C CG  . ASN C 3 63  ? 205.967 273.570 376.447 1.00 10.39 ? 63  ASN C CG  1 
ATOM   4341 O OD1 . ASN C 3 63  ? 206.595 273.900 375.445 1.00 14.55 ? 63  ASN C OD1 1 
ATOM   4342 N ND2 . ASN C 3 63  ? 205.063 274.356 377.016 1.00 12.24 ? 63  ASN C ND2 1 
ATOM   4343 N N   . THR C 3 64  ? 205.072 268.745 376.518 1.00 15.99 ? 64  THR C N   1 
ATOM   4344 C CA  . THR C 3 64  ? 205.270 267.349 376.874 1.00 9.70  ? 64  THR C CA  1 
ATOM   4345 C C   . THR C 3 64  ? 205.010 266.519 375.626 1.00 11.84 ? 64  THR C C   1 
ATOM   4346 O O   . THR C 3 64  ? 204.579 267.038 374.594 1.00 15.83 ? 64  THR C O   1 
ATOM   4347 C CB  . THR C 3 64  ? 204.351 266.901 378.023 1.00 13.76 ? 64  THR C CB  1 
ATOM   4348 O OG1 . THR C 3 64  ? 203.045 266.608 377.514 1.00 17.85 ? 64  THR C OG1 1 
ATOM   4349 C CG2 . THR C 3 64  ? 204.242 267.984 379.094 1.00 12.71 ? 64  THR C CG2 1 
ATOM   4350 N N   . MET C 3 65  ? 205.282 265.216 375.712 1.00 13.43 ? 65  MET C N   1 
ATOM   4351 C CA  . MET C 3 65  ? 204.989 264.343 374.580 1.00 10.06 ? 65  MET C CA  1 
ATOM   4352 C C   . MET C 3 65  ? 203.490 264.274 374.309 1.00 13.27 ? 65  MET C C   1 
ATOM   4353 O O   . MET C 3 65  ? 203.072 264.094 373.158 1.00 13.16 ? 65  MET C O   1 
ATOM   4354 C CB  . MET C 3 65  ? 205.555 262.945 374.834 1.00 10.98 ? 65  MET C CB  1 
ATOM   4355 C CG  . MET C 3 65  ? 207.076 262.899 374.911 1.00 11.93 ? 65  MET C CG  1 
ATOM   4356 S SD  . MET C 3 65  ? 207.892 263.361 373.369 1.00 17.25 ? 65  MET C SD  1 
ATOM   4357 C CE  . MET C 3 65  ? 207.389 262.030 372.284 1.00 11.14 ? 65  MET C CE  1 
ATOM   4358 N N   . ASP C 3 66  ? 202.670 264.452 375.348 1.00 8.92  ? 66  ASP C N   1 
ATOM   4359 C CA  . ASP C 3 66  ? 201.223 264.398 375.179 1.00 10.77 ? 66  ASP C CA  1 
ATOM   4360 C C   . ASP C 3 66  ? 200.729 265.421 374.166 1.00 10.33 ? 66  ASP C C   1 
ATOM   4361 O O   . ASP C 3 66  ? 199.669 265.228 373.562 1.00 18.50 ? 66  ASP C O   1 
ATOM   4362 C CB  . ASP C 3 66  ? 200.530 264.620 376.521 1.00 11.91 ? 66  ASP C CB  1 
ATOM   4363 C CG  . ASP C 3 66  ? 200.722 263.462 377.471 1.00 18.86 ? 66  ASP C CG  1 
ATOM   4364 O OD1 . ASP C 3 66  ? 200.572 262.302 377.034 1.00 24.80 ? 66  ASP C OD1 1 
ATOM   4365 O OD2 . ASP C 3 66  ? 201.031 263.710 378.653 1.00 30.12 ? 66  ASP C OD2 1 
ATOM   4366 N N   . MET C 3 67  ? 201.472 266.510 373.960 1.00 9.16  ? 67  MET C N   1 
ATOM   4367 C CA  . MET C 3 67  ? 201.018 267.522 373.017 1.00 8.33  ? 67  MET C CA  1 
ATOM   4368 C C   . MET C 3 67  ? 200.961 266.990 371.593 1.00 5.77  ? 67  MET C C   1 
ATOM   4369 O O   . MET C 3 67  ? 200.281 267.585 370.752 1.00 10.30 ? 67  MET C O   1 
ATOM   4370 C CB  . MET C 3 67  ? 201.920 268.758 373.081 1.00 14.33 ? 67  MET C CB  1 
ATOM   4371 C CG  . MET C 3 67  ? 203.241 268.638 372.340 1.00 8.34  ? 67  MET C CG  1 
ATOM   4372 S SD  . MET C 3 67  ? 204.309 270.053 372.670 1.00 23.65 ? 67  MET C SD  1 
ATOM   4373 C CE  . MET C 3 67  ? 205.873 269.469 372.035 1.00 9.77  ? 67  MET C CE  1 
ATOM   4374 N N   . TYR C 3 68  ? 201.650 265.888 371.300 1.00 7.18  ? 68  TYR C N   1 
ATOM   4375 C CA  . TYR C 3 68  ? 201.622 265.320 369.960 1.00 12.53 ? 68  TYR C CA  1 
ATOM   4376 C C   . TYR C 3 68  ? 200.472 264.344 369.742 1.00 8.68  ? 68  TYR C C   1 
ATOM   4377 O O   . TYR C 3 68  ? 200.236 263.940 368.600 1.00 14.10 ? 68  TYR C O   1 
ATOM   4378 C CB  . TYR C 3 68  ? 202.946 264.613 369.659 1.00 10.02 ? 68  TYR C CB  1 
ATOM   4379 C CG  . TYR C 3 68  ? 204.124 265.550 369.563 1.00 10.76 ? 68  TYR C CG  1 
ATOM   4380 C CD1 . TYR C 3 68  ? 204.249 266.429 368.497 1.00 8.51  ? 68  TYR C CD1 1 
ATOM   4381 C CD2 . TYR C 3 68  ? 205.116 265.551 370.533 1.00 9.13  ? 68  TYR C CD2 1 
ATOM   4382 C CE1 . TYR C 3 68  ? 205.323 267.283 368.401 1.00 7.99  ? 68  TYR C CE1 1 
ATOM   4383 C CE2 . TYR C 3 68  ? 206.196 266.402 370.445 1.00 11.07 ? 68  TYR C CE2 1 
ATOM   4384 C CZ  . TYR C 3 68  ? 206.296 267.265 369.377 1.00 9.09  ? 68  TYR C CZ  1 
ATOM   4385 O OH  . TYR C 3 68  ? 207.371 268.116 369.287 1.00 15.27 ? 68  TYR C OH  1 
ATOM   4386 N N   . ARG C 3 69  ? 199.746 263.971 370.790 1.00 11.36 ? 69  ARG C N   1 
ATOM   4387 C CA  . ARG C 3 69  ? 198.721 262.940 370.717 1.00 13.24 ? 69  ARG C CA  1 
ATOM   4388 C C   . ARG C 3 69  ? 197.341 263.574 370.811 1.00 12.77 ? 69  ARG C C   1 
ATOM   4389 O O   . ARG C 3 69  ? 197.078 264.362 371.724 1.00 14.82 ? 69  ARG C O   1 
ATOM   4390 C CB  . ARG C 3 69  ? 198.909 261.916 371.839 1.00 5.21  ? 69  ARG C CB  1 
ATOM   4391 C CG  . ARG C 3 69  ? 200.251 261.208 371.796 1.00 16.18 ? 69  ARG C CG  1 
ATOM   4392 C CD  . ARG C 3 69  ? 200.764 260.887 373.186 1.00 12.44 ? 69  ARG C CD  1 
ATOM   4393 N NE  . ARG C 3 69  ? 202.154 260.448 373.157 1.00 13.65 ? 69  ARG C NE  1 
ATOM   4394 C CZ  . ARG C 3 69  ? 202.925 260.324 374.228 1.00 16.21 ? 69  ARG C CZ  1 
ATOM   4395 N NH1 . ARG C 3 69  ? 202.482 260.620 375.438 1.00 14.25 ? 69  ARG C NH1 1 
ATOM   4396 N NH2 . ARG C 3 69  ? 204.174 259.893 374.080 1.00 18.28 ? 69  ARG C NH2 1 
ATOM   4397 N N   . VAL C 3 70  ? 196.463 263.224 369.875 1.00 9.76  ? 70  VAL C N   1 
ATOM   4398 C CA  . VAL C 3 70  ? 195.069 263.659 369.909 1.00 12.38 ? 70  VAL C CA  1 
ATOM   4399 C C   . VAL C 3 70  ? 194.210 262.435 370.188 1.00 7.60  ? 70  VAL C C   1 
ATOM   4400 O O   . VAL C 3 70  ? 194.260 261.450 369.444 1.00 13.96 ? 70  VAL C O   1 
ATOM   4401 C CB  . VAL C 3 70  ? 194.651 264.347 368.600 1.00 13.68 ? 70  VAL C CB  1 
ATOM   4402 C CG1 . VAL C 3 70  ? 193.169 264.690 368.635 1.00 11.21 ? 70  VAL C CG1 1 
ATOM   4403 C CG2 . VAL C 3 70  ? 195.489 265.592 368.366 1.00 11.49 ? 70  VAL C CG2 1 
ATOM   4404 N N   . GLU C 3 71  ? 193.411 262.498 371.246 1.00 10.51 ? 71  GLU C N   1 
ATOM   4405 C CA  . GLU C 3 71  ? 192.687 261.332 371.731 1.00 14.80 ? 71  GLU C CA  1 
ATOM   4406 C C   . GLU C 3 71  ? 191.349 261.193 371.013 1.00 9.87  ? 71  GLU C C   1 
ATOM   4407 O O   . GLU C 3 71  ? 190.534 262.121 371.010 1.00 14.23 ? 71  GLU C O   1 
ATOM   4408 C CB  . GLU C 3 71  ? 192.476 261.421 373.240 1.00 12.59 ? 71  GLU C CB  1 
ATOM   4409 C CG  . GLU C 3 71  ? 191.708 260.244 373.813 1.00 20.55 ? 71  GLU C CG  1 
ATOM   4410 C CD  . GLU C 3 71  ? 191.803 260.163 375.321 1.00 21.34 ? 71  GLU C CD  1 
ATOM   4411 O OE1 . GLU C 3 71  ? 192.891 259.827 375.832 1.00 27.38 ? 71  GLU C OE1 1 
ATOM   4412 O OE2 . GLU C 3 71  ? 190.792 260.442 375.997 1.00 25.52 ? 71  GLU C OE2 1 
ATOM   4413 N N   . LEU C 3 72  ? 191.137 260.036 370.397 1.00 16.05 ? 72  LEU C N   1 
ATOM   4414 C CA  . LEU C 3 72  ? 189.832 259.594 369.937 1.00 12.42 ? 72  LEU C CA  1 
ATOM   4415 C C   . LEU C 3 72  ? 189.274 258.580 370.928 1.00 11.11 ? 72  LEU C C   1 
ATOM   4416 O O   . LEU C 3 72  ? 190.024 257.914 371.645 1.00 19.26 ? 72  LEU C O   1 
ATOM   4417 C CB  . LEU C 3 72  ? 189.921 258.960 368.548 1.00 11.32 ? 72  LEU C CB  1 
ATOM   4418 C CG  . LEU C 3 72  ? 190.574 259.771 367.429 1.00 13.31 ? 72  LEU C CG  1 
ATOM   4419 C CD1 . LEU C 3 72  ? 190.610 258.960 366.145 1.00 12.82 ? 72  LEU C CD1 1 
ATOM   4420 C CD2 . LEU C 3 72  ? 189.849 261.084 367.215 1.00 13.17 ? 72  LEU C CD2 1 
ATOM   4421 N N   . ASN C 3 73  ? 187.948 258.470 370.966 1.00 12.40 ? 73  ASN C N   1 
ATOM   4422 C CA  . ASN C 3 73  ? 187.278 257.456 371.766 1.00 15.07 ? 73  ASN C CA  1 
ATOM   4423 C C   . ASN C 3 73  ? 186.144 256.858 370.946 1.00 9.53  ? 73  ASN C C   1 
ATOM   4424 O O   . ASN C 3 73  ? 185.858 257.300 369.831 1.00 17.82 ? 73  ASN C O   1 
ATOM   4425 C CB  . ASN C 3 73  ? 186.767 258.028 373.097 1.00 11.00 ? 73  ASN C CB  1 
ATOM   4426 C CG  . ASN C 3 73  ? 185.802 259.178 372.912 1.00 15.12 ? 73  ASN C CG  1 
ATOM   4427 O OD1 . ASN C 3 73  ? 184.963 259.168 372.015 1.00 20.10 ? 73  ASN C OD1 1 
ATOM   4428 N ND2 . ASN C 3 73  ? 185.920 260.185 373.768 1.00 19.10 ? 73  ASN C ND2 1 
ATOM   4429 N N   . ASP C 3 74  ? 185.496 255.837 371.505 1.00 14.78 ? 74  ASP C N   1 
ATOM   4430 C CA  . ASP C 3 74  ? 184.449 255.101 370.809 1.00 14.01 ? 74  ASP C CA  1 
ATOM   4431 C C   . ASP C 3 74  ? 183.049 255.592 371.164 1.00 8.51  ? 74  ASP C C   1 
ATOM   4432 O O   . ASP C 3 74  ? 182.080 254.842 371.010 1.00 21.24 ? 74  ASP C O   1 
ATOM   4433 C CB  . ASP C 3 74  ? 184.570 253.605 371.103 1.00 8.20  ? 74  ASP C CB  1 
ATOM   4434 C CG  . ASP C 3 74  ? 184.076 253.238 372.491 1.00 17.11 ? 74  ASP C CG  1 
ATOM   4435 O OD1 . ASP C 3 74  ? 184.260 254.043 373.426 1.00 18.67 ? 74  ASP C OD1 1 
ATOM   4436 O OD2 . ASP C 3 74  ? 183.496 252.144 372.644 1.00 17.89 ? 74  ASP C OD2 1 
ATOM   4437 N N   . ALA C 3 75  ? 182.921 256.831 371.630 1.00 14.21 ? 75  ALA C N   1 
ATOM   4438 C CA  . ALA C 3 75  ? 181.619 257.364 371.993 1.00 10.32 ? 75  ALA C CA  1 
ATOM   4439 C C   . ALA C 3 75  ? 180.719 257.474 370.760 1.00 11.93 ? 75  ALA C C   1 
ATOM   4440 O O   . ALA C 3 75  ? 181.149 257.300 369.618 1.00 17.48 ? 75  ALA C O   1 
ATOM   4441 C CB  . ALA C 3 75  ? 181.770 258.729 372.661 1.00 14.07 ? 75  ALA C CB  1 
ATOM   4442 N N   . ALA C 3 76  ? 179.449 257.776 371.010 1.00 16.50 ? 76  ALA C N   1 
ATOM   4443 C CA  . ALA C 3 76  ? 178.475 257.884 369.934 1.00 11.97 ? 76  ALA C CA  1 
ATOM   4444 C C   . ALA C 3 76  ? 178.847 259.019 368.985 1.00 14.98 ? 76  ALA C C   1 
ATOM   4445 O O   . ALA C 3 76  ? 179.540 259.973 369.349 1.00 21.19 ? 76  ALA C O   1 
ATOM   4446 C CB  . ALA C 3 76  ? 177.075 258.113 370.499 1.00 11.77 ? 76  ALA C CB  1 
ATOM   4447 N N   . HIS C 3 77  ? 178.369 258.906 367.749 1.00 10.61 ? 77  HIS C N   1 
ATOM   4448 C CA  . HIS C 3 77  ? 178.713 259.880 366.725 1.00 13.83 ? 77  HIS C CA  1 
ATOM   4449 C C   . HIS C 3 77  ? 178.296 261.285 367.137 1.00 11.58 ? 77  HIS C C   1 
ATOM   4450 O O   . HIS C 3 77  ? 177.234 261.490 367.730 1.00 17.95 ? 77  HIS C O   1 
ATOM   4451 C CB  . HIS C 3 77  ? 178.042 259.530 365.400 1.00 12.25 ? 77  HIS C CB  1 
ATOM   4452 C CG  . HIS C 3 77  ? 178.231 260.574 364.345 1.00 13.43 ? 77  HIS C CG  1 
ATOM   4453 N ND1 . HIS C 3 77  ? 179.344 260.620 363.534 1.00 13.18 ? 77  HIS C ND1 1 
ATOM   4454 C CD2 . HIS C 3 77  ? 177.462 261.629 363.988 1.00 9.93  ? 77  HIS C CD2 1 
ATOM   4455 C CE1 . HIS C 3 77  ? 179.244 261.648 362.712 1.00 13.55 ? 77  HIS C CE1 1 
ATOM   4456 N NE2 . HIS C 3 77  ? 178.113 262.278 362.967 1.00 12.31 ? 77  HIS C NE2 1 
ATOM   4457 N N   . SER C 3 78  ? 179.147 262.253 366.815 1.00 14.72 ? 78  SER C N   1 
ATOM   4458 C CA  . SER C 3 78  ? 178.801 263.662 366.900 1.00 14.85 ? 78  SER C CA  1 
ATOM   4459 C C   . SER C 3 78  ? 179.394 264.368 365.691 1.00 12.43 ? 78  SER C C   1 
ATOM   4460 O O   . SER C 3 78  ? 180.266 263.834 365.003 1.00 15.96 ? 78  SER C O   1 
ATOM   4461 C CB  . SER C 3 78  ? 179.308 264.302 368.198 1.00 15.93 ? 78  SER C CB  1 
ATOM   4462 O OG  . SER C 3 78  ? 180.721 264.369 368.216 1.00 24.90 ? 78  SER C OG  1 
ATOM   4463 N N   . ASP C 3 79  ? 178.903 265.575 365.429 1.00 17.20 ? 79  ASP C N   1 
ATOM   4464 C CA  . ASP C 3 79  ? 179.429 266.409 364.359 1.00 11.40 ? 79  ASP C CA  1 
ATOM   4465 C C   . ASP C 3 79  ? 180.448 267.430 364.850 1.00 12.85 ? 79  ASP C C   1 
ATOM   4466 O O   . ASP C 3 79  ? 180.933 268.232 364.048 1.00 18.41 ? 79  ASP C O   1 
ATOM   4467 C CB  . ASP C 3 79  ? 178.284 267.131 363.640 1.00 10.75 ? 79  ASP C CB  1 
ATOM   4468 C CG  . ASP C 3 79  ? 177.544 266.232 362.664 1.00 19.21 ? 79  ASP C CG  1 
ATOM   4469 O OD1 . ASP C 3 79  ? 177.877 265.033 362.578 1.00 22.49 ? 79  ASP C OD1 1 
ATOM   4470 O OD2 . ASP C 3 79  ? 176.629 266.728 361.974 1.00 24.37 ? 79  ASP C OD2 1 
ATOM   4471 N N   . THR C 3 80  ? 180.786 267.425 366.136 1.00 13.59 ? 80  THR C N   1 
ATOM   4472 C CA  . THR C 3 80  ? 181.752 268.383 366.646 1.00 12.00 ? 80  THR C CA  1 
ATOM   4473 C C   . THR C 3 80  ? 183.165 267.986 366.216 1.00 7.18  ? 80  THR C C   1 
ATOM   4474 O O   . THR C 3 80  ? 183.464 266.801 366.059 1.00 10.81 ? 80  THR C O   1 
ATOM   4475 C CB  . THR C 3 80  ? 181.678 268.471 368.167 1.00 11.95 ? 80  THR C CB  1 
ATOM   4476 O OG1 . THR C 3 80  ? 182.007 267.202 368.742 1.00 24.54 ? 80  THR C OG1 1 
ATOM   4477 C CG2 . THR C 3 80  ? 180.282 268.877 368.606 1.00 16.40 ? 80  THR C CG2 1 
ATOM   4478 N N   . PRO C 3 81  ? 184.051 268.958 366.012 1.00 12.42 ? 81  PRO C N   1 
ATOM   4479 C CA  . PRO C 3 81  ? 185.391 268.629 365.519 1.00 12.23 ? 81  PRO C CA  1 
ATOM   4480 C C   . PRO C 3 81  ? 186.223 267.884 366.548 1.00 4.45  ? 81  PRO C C   1 
ATOM   4481 O O   . PRO C 3 81  ? 186.103 268.090 367.757 1.00 7.92  ? 81  PRO C O   1 
ATOM   4482 C CB  . PRO C 3 81  ? 186.000 269.998 365.200 1.00 8.87  ? 81  PRO C CB  1 
ATOM   4483 C CG  . PRO C 3 81  ? 185.260 270.949 366.057 1.00 11.44 ? 81  PRO C CG  1 
ATOM   4484 C CD  . PRO C 3 81  ? 183.871 270.409 366.187 1.00 11.97 ? 81  PRO C CD  1 
ATOM   4485 N N   . ILE C 3 82  ? 187.069 266.991 366.038 1.00 11.30 ? 82  ILE C N   1 
ATOM   4486 C CA  . ILE C 3 82  ? 188.101 266.371 366.860 1.00 8.44  ? 82  ILE C CA  1 
ATOM   4487 C C   . ILE C 3 82  ? 189.240 267.349 367.109 1.00 9.80  ? 82  ILE C C   1 
ATOM   4488 O O   . ILE C 3 82  ? 189.732 267.473 368.235 1.00 19.77 ? 82  ILE C O   1 
ATOM   4489 C CB  . ILE C 3 82  ? 188.600 265.081 366.186 1.00 10.82 ? 82  ILE C CB  1 
ATOM   4490 C CG1 . ILE C 3 82  ? 187.529 263.992 366.275 1.00 6.04  ? 82  ILE C CG1 1 
ATOM   4491 C CG2 . ILE C 3 82  ? 189.912 264.622 366.813 1.00 9.21  ? 82  ILE C CG2 1 
ATOM   4492 C CD1 . ILE C 3 82  ? 187.581 262.993 365.145 1.00 7.34  ? 82  ILE C CD1 1 
ATOM   4493 N N   . LEU C 3 83  ? 189.681 268.047 366.065 1.00 12.22 ? 83  LEU C N   1 
ATOM   4494 C CA  . LEU C 3 83  ? 190.760 269.015 366.174 1.00 13.12 ? 83  LEU C CA  1 
ATOM   4495 C C   . LEU C 3 83  ? 190.563 270.085 365.112 1.00 11.80 ? 83  LEU C C   1 
ATOM   4496 O O   . LEU C 3 83  ? 189.938 269.844 364.074 1.00 14.80 ? 83  LEU C O   1 
ATOM   4497 C CB  . LEU C 3 83  ? 192.135 268.350 366.023 1.00 9.14  ? 83  LEU C CB  1 
ATOM   4498 C CG  . LEU C 3 83  ? 192.401 267.613 364.706 1.00 12.06 ? 83  LEU C CG  1 
ATOM   4499 C CD1 . LEU C 3 83  ? 192.875 268.560 363.605 1.00 11.26 ? 83  LEU C CD1 1 
ATOM   4500 C CD2 . LEU C 3 83  ? 193.397 266.485 364.918 1.00 13.66 ? 83  LEU C CD2 1 
ATOM   4501 N N   . CYS C 3 84  ? 191.114 271.266 365.386 1.00 9.39  ? 84  CYS C N   1 
ATOM   4502 C CA  . CYS C 3 84  ? 190.984 272.425 364.515 1.00 13.85 ? 84  CYS C CA  1 
ATOM   4503 C C   . CYS C 3 84  ? 192.268 273.236 364.576 1.00 14.12 ? 84  CYS C C   1 
ATOM   4504 O O   . CYS C 3 84  ? 192.821 273.445 365.659 1.00 20.64 ? 84  CYS C O   1 
ATOM   4505 C CB  . CYS C 3 84  ? 189.807 273.311 364.936 1.00 7.65  ? 84  CYS C CB  1 
ATOM   4506 S SG  . CYS C 3 84  ? 188.249 272.451 365.179 1.00 23.39 ? 84  CYS C SG  1 
ATOM   4507 N N   . PHE C 3 85  ? 192.732 273.704 363.420 1.00 6.81  ? 85  PHE C N   1 
ATOM   4508 C CA  . PHE C 3 85  ? 193.844 274.646 363.406 1.00 13.14 ? 85  PHE C CA  1 
ATOM   4509 C C   . PHE C 3 85  ? 193.876 275.377 362.072 1.00 12.43 ? 85  PHE C C   1 
ATOM   4510 O O   . PHE C 3 85  ? 193.394 274.871 361.059 1.00 11.17 ? 85  PHE C O   1 
ATOM   4511 C CB  . PHE C 3 85  ? 195.185 273.949 363.686 1.00 8.73  ? 85  PHE C CB  1 
ATOM   4512 C CG  . PHE C 3 85  ? 195.579 272.920 362.661 1.00 4.21  ? 85  PHE C CG  1 
ATOM   4513 C CD1 . PHE C 3 85  ? 196.338 273.276 361.560 1.00 7.30  ? 85  PHE C CD1 1 
ATOM   4514 C CD2 . PHE C 3 85  ? 195.214 271.593 362.814 1.00 8.05  ? 85  PHE C CD2 1 
ATOM   4515 C CE1 . PHE C 3 85  ? 196.710 272.330 360.622 1.00 11.55 ? 85  PHE C CE1 1 
ATOM   4516 C CE2 . PHE C 3 85  ? 195.586 270.643 361.880 1.00 7.95  ? 85  PHE C CE2 1 
ATOM   4517 C CZ  . PHE C 3 85  ? 196.333 271.013 360.784 1.00 11.73 ? 85  PHE C CZ  1 
ATOM   4518 N N   . SER C 3 86  ? 194.461 276.568 362.083 1.00 12.67 ? 86  SER C N   1 
ATOM   4519 C CA  . SER C 3 86  ? 194.490 277.404 360.894 1.00 10.22 ? 86  SER C CA  1 
ATOM   4520 C C   . SER C 3 86  ? 195.681 277.056 360.010 1.00 9.36  ? 86  SER C C   1 
ATOM   4521 O O   . SER C 3 86  ? 196.709 276.563 360.480 1.00 15.64 ? 86  SER C O   1 
ATOM   4522 C CB  . SER C 3 86  ? 194.542 278.880 361.283 1.00 12.65 ? 86  SER C CB  1 
ATOM   4523 O OG  . SER C 3 86  ? 193.400 279.238 362.038 1.00 20.17 ? 86  SER C OG  1 
ATOM   4524 N N   . LEU C 3 87  ? 195.525 277.312 358.711 1.00 10.43 ? 87  LEU C N   1 
ATOM   4525 C CA  . LEU C 3 87  ? 196.580 277.051 357.732 1.00 12.21 ? 87  LEU C CA  1 
ATOM   4526 C C   . LEU C 3 87  ? 197.530 278.249 357.690 1.00 15.59 ? 87  LEU C C   1 
ATOM   4527 O O   . LEU C 3 87  ? 197.585 279.021 356.732 1.00 16.23 ? 87  LEU C O   1 
ATOM   4528 C CB  . LEU C 3 87  ? 195.986 276.763 356.361 1.00 11.60 ? 87  LEU C CB  1 
ATOM   4529 C CG  . LEU C 3 87  ? 196.953 276.099 355.380 1.00 17.16 ? 87  LEU C CG  1 
ATOM   4530 C CD1 . LEU C 3 87  ? 197.004 274.599 355.635 1.00 15.06 ? 87  LEU C CD1 1 
ATOM   4531 C CD2 . LEU C 3 87  ? 196.582 276.393 353.933 1.00 10.00 ? 87  LEU C CD2 1 
ATOM   4532 N N   . SER C 3 88  ? 198.282 278.397 358.775 1.00 14.70 ? 88  SER C N   1 
ATOM   4533 C CA  . SER C 3 88  ? 199.344 279.394 358.890 1.00 9.36  ? 88  SER C CA  1 
ATOM   4534 C C   . SER C 3 88  ? 200.589 278.629 359.308 1.00 9.43  ? 88  SER C C   1 
ATOM   4535 O O   . SER C 3 88  ? 200.942 278.592 360.493 1.00 16.81 ? 88  SER C O   1 
ATOM   4536 C CB  . SER C 3 88  ? 198.985 280.491 359.891 1.00 12.45 ? 88  SER C CB  1 
ATOM   4537 O OG  . SER C 3 88  ? 197.832 281.202 359.481 1.00 23.47 ? 88  SER C OG  1 
ATOM   4538 N N   . PRO C 3 89  ? 201.271 277.987 358.357 1.00 10.21 ? 89  PRO C N   1 
ATOM   4539 C CA  . PRO C 3 89  ? 202.334 277.041 358.732 1.00 8.20  ? 89  PRO C CA  1 
ATOM   4540 C C   . PRO C 3 89  ? 203.476 277.673 359.503 1.00 6.23  ? 89  PRO C C   1 
ATOM   4541 O O   . PRO C 3 89  ? 204.180 276.957 360.223 1.00 25.20 ? 89  PRO C O   1 
ATOM   4542 C CB  . PRO C 3 89  ? 202.802 276.485 357.380 1.00 10.00 ? 89  PRO C CB  1 
ATOM   4543 C CG  . PRO C 3 89  ? 202.419 277.524 356.383 1.00 7.73  ? 89  PRO C CG  1 
ATOM   4544 C CD  . PRO C 3 89  ? 201.160 278.145 356.898 1.00 9.79  ? 89  PRO C CD  1 
ATOM   4545 N N   . ALA C 3 90  ? 203.684 278.983 359.385 1.00 10.48 ? 90  ALA C N   1 
ATOM   4546 C CA  . ALA C 3 90  ? 204.770 279.652 360.088 1.00 8.19  ? 90  ALA C CA  1 
ATOM   4547 C C   . ALA C 3 90  ? 204.339 280.313 361.389 1.00 2.47  ? 90  ALA C C   1 
ATOM   4548 O O   . ALA C 3 90  ? 205.189 280.540 362.254 1.00 12.33 ? 90  ALA C O   1 
ATOM   4549 C CB  . ALA C 3 90  ? 205.409 280.714 359.188 1.00 7.10  ? 90  ALA C CB  1 
ATOM   4550 N N   . SER C 3 91  ? 203.055 280.620 361.557 1.00 14.66 ? 91  SER C N   1 
ATOM   4551 C CA  . SER C 3 91  ? 202.594 281.399 362.698 1.00 13.58 ? 91  SER C CA  1 
ATOM   4552 C C   . SER C 3 91  ? 201.548 280.698 363.550 1.00 7.63  ? 91  SER C C   1 
ATOM   4553 O O   . SER C 3 91  ? 201.370 281.080 364.707 1.00 16.93 ? 91  SER C O   1 
ATOM   4554 C CB  . SER C 3 91  ? 202.027 282.749 362.229 1.00 8.15  ? 91  SER C CB  1 
ATOM   4555 O OG  . SER C 3 91  ? 200.960 282.573 361.318 1.00 21.16 ? 91  SER C OG  1 
ATOM   4556 N N   . ASP C 3 92  ? 200.848 279.705 363.023 1.00 12.73 ? 92  ASP C N   1 
ATOM   4557 C CA  . ASP C 3 92  ? 199.943 278.924 363.853 1.00 13.31 ? 92  ASP C CA  1 
ATOM   4558 C C   . ASP C 3 92  ? 200.771 278.124 364.854 1.00 13.07 ? 92  ASP C C   1 
ATOM   4559 O O   . ASP C 3 92  ? 201.690 277.401 364.443 1.00 16.92 ? 92  ASP C O   1 
ATOM   4560 C CB  . ASP C 3 92  ? 199.079 277.995 363.002 1.00 8.27  ? 92  ASP C CB  1 
ATOM   4561 C CG  . ASP C 3 92  ? 198.061 277.220 363.826 1.00 14.59 ? 92  ASP C CG  1 
ATOM   4562 O OD1 . ASP C 3 92  ? 198.460 276.507 364.766 1.00 23.04 ? 92  ASP C OD1 1 
ATOM   4563 O OD2 . ASP C 3 92  ? 196.853 277.326 363.537 1.00 22.68 ? 92  ASP C OD2 1 
ATOM   4564 N N   . PRO C 3 93  ? 200.491 278.217 366.157 1.00 12.40 ? 93  PRO C N   1 
ATOM   4565 C CA  . PRO C 3 93  ? 201.381 277.575 367.140 1.00 14.44 ? 93  PRO C CA  1 
ATOM   4566 C C   . PRO C 3 93  ? 201.561 276.078 366.934 1.00 11.62 ? 93  PRO C C   1 
ATOM   4567 O O   . PRO C 3 93  ? 202.643 275.557 367.222 1.00 22.53 ? 93  PRO C O   1 
ATOM   4568 C CB  . PRO C 3 93  ? 200.707 277.894 368.485 1.00 12.70 ? 93  PRO C CB  1 
ATOM   4569 C CG  . PRO C 3 93  ? 199.323 278.325 368.154 1.00 16.61 ? 93  PRO C CG  1 
ATOM   4570 C CD  . PRO C 3 93  ? 199.389 278.945 366.805 1.00 16.02 ? 93  PRO C CD  1 
ATOM   4571 N N   . ARG C 3 94  ? 200.541 275.366 366.448 1.00 15.54 ? 94  ARG C N   1 
ATOM   4572 C CA  . ARG C 3 94  ? 200.717 273.938 366.201 1.00 7.84  ? 94  ARG C CA  1 
ATOM   4573 C C   . ARG C 3 94  ? 201.690 273.678 365.059 1.00 8.41  ? 94  ARG C C   1 
ATOM   4574 O O   . ARG C 3 94  ? 202.384 272.657 365.065 1.00 16.71 ? 94  ARG C O   1 
ATOM   4575 C CB  . ARG C 3 94  ? 199.381 273.266 365.888 1.00 14.16 ? 94  ARG C CB  1 
ATOM   4576 C CG  . ARG C 3 94  ? 198.370 273.307 367.014 1.00 9.94  ? 94  ARG C CG  1 
ATOM   4577 C CD  . ARG C 3 94  ? 197.502 274.539 366.920 1.00 17.16 ? 94  ARG C CD  1 
ATOM   4578 N NE  . ARG C 3 94  ? 196.191 274.299 367.499 1.00 18.39 ? 94  ARG C NE  1 
ATOM   4579 C CZ  . ARG C 3 94  ? 195.100 274.986 367.197 1.00 16.61 ? 94  ARG C CZ  1 
ATOM   4580 N NH1 . ARG C 3 94  ? 195.129 275.984 366.328 1.00 9.10  ? 94  ARG C NH1 1 
ATOM   4581 N NH2 . ARG C 3 94  ? 193.951 274.657 367.775 1.00 17.19 ? 94  ARG C NH2 1 
ATOM   4582 N N   . LEU C 3 95  ? 201.749 274.571 364.074 1.00 12.25 ? 95  LEU C N   1 
ATOM   4583 C CA  . LEU C 3 95  ? 202.582 274.358 362.899 1.00 11.61 ? 95  LEU C CA  1 
ATOM   4584 C C   . LEU C 3 95  ? 203.904 275.112 362.945 1.00 1.90  ? 95  LEU C C   1 
ATOM   4585 O O   . LEU C 3 95  ? 204.838 274.730 362.232 1.00 9.84  ? 95  LEU C O   1 
ATOM   4586 C CB  . LEU C 3 95  ? 201.817 274.768 361.634 1.00 3.36  ? 95  LEU C CB  1 
ATOM   4587 C CG  . LEU C 3 95  ? 200.478 274.063 361.397 1.00 13.96 ? 95  LEU C CG  1 
ATOM   4588 C CD1 . LEU C 3 95  ? 199.757 274.683 360.212 1.00 12.12 ? 95  LEU C CD1 1 
ATOM   4589 C CD2 . LEU C 3 95  ? 200.678 272.566 361.190 1.00 9.52  ? 95  LEU C CD2 1 
ATOM   4590 N N   . ALA C 3 96  ? 204.010 276.156 363.769 1.00 8.41  ? 96  ALA C N   1 
ATOM   4591 C CA  . ALA C 3 96  ? 205.187 277.020 363.730 1.00 10.03 ? 96  ALA C CA  1 
ATOM   4592 C C   . ALA C 3 96  ? 206.454 276.262 364.103 1.00 12.10 ? 96  ALA C C   1 
ATOM   4593 O O   . ALA C 3 96  ? 207.520 276.500 363.524 1.00 14.63 ? 96  ALA C O   1 
ATOM   4594 C CB  . ALA C 3 96  ? 204.988 278.215 364.661 1.00 7.86  ? 96  ALA C CB  1 
ATOM   4595 N N   . HIS C 3 97  ? 206.364 275.351 365.066 1.00 4.97  ? 97  HIS C N   1 
ATOM   4596 C CA  . HIS C 3 97  ? 207.532 274.631 365.552 1.00 8.02  ? 97  HIS C CA  1 
ATOM   4597 C C   . HIS C 3 97  ? 207.744 273.285 364.872 1.00 9.19  ? 97  HIS C C   1 
ATOM   4598 O O   . HIS C 3 97  ? 208.650 272.548 365.268 1.00 13.66 ? 97  HIS C O   1 
ATOM   4599 C CB  . HIS C 3 97  ? 207.435 274.439 367.063 1.00 5.03  ? 97  HIS C CB  1 
ATOM   4600 C CG  . HIS C 3 97  ? 207.454 275.722 367.830 1.00 16.59 ? 97  HIS C CG  1 
ATOM   4601 N ND1 . HIS C 3 97  ? 206.314 276.451 368.090 1.00 16.10 ? 97  HIS C ND1 1 
ATOM   4602 C CD2 . HIS C 3 97  ? 208.478 276.417 368.378 1.00 15.99 ? 97  HIS C CD2 1 
ATOM   4603 C CE1 . HIS C 3 97  ? 206.634 277.534 368.773 1.00 16.58 ? 97  HIS C CE1 1 
ATOM   4604 N NE2 . HIS C 3 97  ? 207.941 277.537 368.962 1.00 19.10 ? 97  HIS C NE2 1 
ATOM   4605 N N   . THR C 3 98  ? 206.943 272.939 363.870 1.00 11.26 ? 98  THR C N   1 
ATOM   4606 C CA  . THR C 3 98  ? 207.300 271.813 363.025 1.00 5.07  ? 98  THR C CA  1 
ATOM   4607 C C   . THR C 3 98  ? 208.498 272.192 362.160 1.00 1.40  ? 98  THR C C   1 
ATOM   4608 O O   . THR C 3 98  ? 208.817 273.369 361.980 1.00 9.44  ? 98  THR C O   1 
ATOM   4609 C CB  . THR C 3 98  ? 206.124 271.391 362.139 1.00 7.74  ? 98  THR C CB  1 
ATOM   4610 O OG1 . THR C 3 98  ? 205.840 272.421 361.184 1.00 7.02  ? 98  THR C OG1 1 
ATOM   4611 C CG2 . THR C 3 98  ? 204.885 271.118 362.980 1.00 9.71  ? 98  THR C CG2 1 
ATOM   4612 N N   . MET C 3 99  ? 209.179 271.176 361.630 1.00 5.28  ? 99  MET C N   1 
ATOM   4613 C CA  . MET C 3 99  ? 210.330 271.448 360.775 1.00 9.32  ? 99  MET C CA  1 
ATOM   4614 C C   . MET C 3 99  ? 209.957 272.408 359.653 1.00 4.12  ? 99  MET C C   1 
ATOM   4615 O O   . MET C 3 99  ? 210.705 273.345 359.347 1.00 10.62 ? 99  MET C O   1 
ATOM   4616 C CB  . MET C 3 99  ? 210.885 270.142 360.206 1.00 6.73  ? 99  MET C CB  1 
ATOM   4617 C CG  . MET C 3 99  ? 211.970 270.338 359.160 1.00 3.73  ? 99  MET C CG  1 
ATOM   4618 S SD  . MET C 3 99  ? 213.310 271.410 359.717 1.00 28.36 ? 99  MET C SD  1 
ATOM   4619 C CE  . MET C 3 99  ? 214.339 270.247 360.601 1.00 3.66  ? 99  MET C CE  1 
ATOM   4620 N N   . LEU C 3 100 ? 208.789 272.199 359.041 1.00 13.18 ? 100 LEU C N   1 
ATOM   4621 C CA  . LEU C 3 100 ? 208.305 273.118 358.018 1.00 10.33 ? 100 LEU C CA  1 
ATOM   4622 C C   . LEU C 3 100 ? 208.144 274.524 358.581 1.00 6.55  ? 100 LEU C C   1 
ATOM   4623 O O   . LEU C 3 100 ? 208.568 275.505 357.962 1.00 8.57  ? 100 LEU C O   1 
ATOM   4624 C CB  . LEU C 3 100 ? 206.979 272.610 357.450 1.00 7.28  ? 100 LEU C CB  1 
ATOM   4625 C CG  . LEU C 3 100 ? 206.195 273.582 356.561 1.00 8.68  ? 100 LEU C CG  1 
ATOM   4626 C CD1 . LEU C 3 100 ? 206.965 273.900 355.289 1.00 12.03 ? 100 LEU C CD1 1 
ATOM   4627 C CD2 . LEU C 3 100 ? 204.823 273.021 356.233 1.00 12.15 ? 100 LEU C CD2 1 
ATOM   4628 N N   . GLY C 3 101 ? 207.519 274.642 359.753 1.00 0.01  ? 101 GLY C N   1 
ATOM   4629 C CA  . GLY C 3 101 ? 207.369 275.950 360.365 1.00 5.55  ? 101 GLY C CA  1 
ATOM   4630 C C   . GLY C 3 101 ? 208.702 276.588 360.701 1.00 5.30  ? 101 GLY C C   1 
ATOM   4631 O O   . GLY C 3 101 ? 208.893 277.792 360.508 1.00 8.14  ? 101 GLY C O   1 
ATOM   4632 N N   . GLU C 3 102 ? 209.644 275.789 361.206 1.00 9.36  ? 102 GLU C N   1 
ATOM   4633 C CA  . GLU C 3 102 ? 210.962 276.314 361.543 1.00 6.51  ? 102 GLU C CA  1 
ATOM   4634 C C   . GLU C 3 102 ? 211.653 276.880 360.311 1.00 1.09  ? 102 GLU C C   1 
ATOM   4635 O O   . GLU C 3 102 ? 212.238 277.967 360.355 1.00 9.67  ? 102 GLU C O   1 
ATOM   4636 C CB  . GLU C 3 102 ? 211.816 275.213 362.172 1.00 8.64  ? 102 GLU C CB  1 
ATOM   4637 C CG  . GLU C 3 102 ? 211.308 274.709 363.506 1.00 7.72  ? 102 GLU C CG  1 
ATOM   4638 C CD  . GLU C 3 102 ? 211.387 275.759 364.589 1.00 16.21 ? 102 GLU C CD  1 
ATOM   4639 O OE1 . GLU C 3 102 ? 212.052 276.790 364.370 1.00 14.62 ? 102 GLU C OE1 1 
ATOM   4640 O OE2 . GLU C 3 102 ? 210.780 275.560 365.659 1.00 21.62 ? 102 GLU C OE2 1 
ATOM   4641 N N   . ILE C 3 103 ? 211.601 276.148 359.198 1.00 4.65  ? 103 ILE C N   1 
ATOM   4642 C CA  . ILE C 3 103 ? 212.204 276.643 357.965 1.00 7.27  ? 103 ILE C CA  1 
ATOM   4643 C C   . ILE C 3 103 ? 211.484 277.898 357.485 1.00 2.39  ? 103 ILE C C   1 
ATOM   4644 O O   . ILE C 3 103 ? 212.120 278.880 357.085 1.00 8.01  ? 103 ILE C O   1 
ATOM   4645 C CB  . ILE C 3 103 ? 212.200 275.540 356.892 1.00 7.78  ? 103 ILE C CB  1 
ATOM   4646 C CG1 . ILE C 3 103 ? 213.114 274.390 357.321 1.00 10.40 ? 103 ILE C CG1 1 
ATOM   4647 C CG2 . ILE C 3 103 ? 212.635 276.105 355.547 1.00 10.20 ? 103 ILE C CG2 1 
ATOM   4648 C CD1 . ILE C 3 103 ? 212.905 273.124 356.534 1.00 14.72 ? 103 ILE C CD1 1 
ATOM   4649 N N   . LEU C 3 104 ? 210.149 277.888 357.518 1.00 9.34  ? 104 LEU C N   1 
ATOM   4650 C CA  . LEU C 3 104 ? 209.389 279.027 357.017 1.00 8.34  ? 104 LEU C CA  1 
ATOM   4651 C C   . LEU C 3 104 ? 209.637 280.276 357.848 1.00 11.45 ? 104 LEU C C   1 
ATOM   4652 O O   . LEU C 3 104 ? 209.510 281.393 357.337 1.00 8.04  ? 104 LEU C O   1 
ATOM   4653 C CB  . LEU C 3 104 ? 207.897 278.697 356.998 1.00 5.28  ? 104 LEU C CB  1 
ATOM   4654 C CG  . LEU C 3 104 ? 207.342 278.058 355.723 1.00 7.76  ? 104 LEU C CG  1 
ATOM   4655 C CD1 . LEU C 3 104 ? 208.302 277.037 355.136 1.00 14.16 ? 104 LEU C CD1 1 
ATOM   4656 C CD2 . LEU C 3 104 ? 205.999 277.419 356.021 1.00 14.14 ? 104 LEU C CD2 1 
ATOM   4657 N N   . ASN C 3 105 ? 209.990 280.114 359.122 1.00 6.98  ? 105 ASN C N   1 
ATOM   4658 C CA  . ASN C 3 105 ? 210.238 281.276 359.966 1.00 2.66  ? 105 ASN C CA  1 
ATOM   4659 C C   . ASN C 3 105 ? 211.575 281.950 359.677 1.00 9.42  ? 105 ASN C C   1 
ATOM   4660 O O   . ASN C 3 105 ? 211.852 283.000 360.263 1.00 12.65 ? 105 ASN C O   1 
ATOM   4661 C CB  . ASN C 3 105 ? 210.147 280.878 361.435 1.00 4.86  ? 105 ASN C CB  1 
ATOM   4662 C CG  . ASN C 3 105 ? 208.735 280.987 361.971 1.00 9.88  ? 105 ASN C CG  1 
ATOM   4663 O OD1 . ASN C 3 105 ? 208.329 282.040 362.453 1.00 18.42 ? 105 ASN C OD1 1 
ATOM   4664 N ND2 . ASN C 3 105 ? 207.976 279.902 361.880 1.00 8.84  ? 105 ASN C ND2 1 
ATOM   4665 N N   . TYR C 3 106 ? 212.404 281.381 358.805 1.00 3.01  ? 106 TYR C N   1 
ATOM   4666 C CA  . TYR C 3 106 ? 213.559 282.084 358.263 1.00 4.65  ? 106 TYR C CA  1 
ATOM   4667 C C   . TYR C 3 106 ? 213.252 282.785 356.945 1.00 6.72  ? 106 TYR C C   1 
ATOM   4668 O O   . TYR C 3 106 ? 214.159 283.361 356.340 1.00 11.24 ? 106 TYR C O   1 
ATOM   4669 C CB  . TYR C 3 106 ? 214.730 281.117 358.061 1.00 3.67  ? 106 TYR C CB  1 
ATOM   4670 C CG  . TYR C 3 106 ? 215.443 280.741 359.338 1.00 2.92  ? 106 TYR C CG  1 
ATOM   4671 C CD1 . TYR C 3 106 ? 216.413 281.572 359.884 1.00 7.16  ? 106 TYR C CD1 1 
ATOM   4672 C CD2 . TYR C 3 106 ? 215.149 279.555 359.996 1.00 1.39  ? 106 TYR C CD2 1 
ATOM   4673 C CE1 . TYR C 3 106 ? 217.068 281.235 361.050 1.00 9.29  ? 106 TYR C CE1 1 
ATOM   4674 C CE2 . TYR C 3 106 ? 215.800 279.207 361.162 1.00 7.97  ? 106 TYR C CE2 1 
ATOM   4675 C CZ  . TYR C 3 106 ? 216.759 280.050 361.685 1.00 7.37  ? 106 TYR C CZ  1 
ATOM   4676 O OH  . TYR C 3 106 ? 217.410 279.711 362.845 1.00 16.21 ? 106 TYR C OH  1 
ATOM   4677 N N   . TYR C 3 107 ? 212.006 282.741 356.482 1.00 9.98  ? 107 TYR C N   1 
ATOM   4678 C CA  . TYR C 3 107 ? 211.620 283.360 355.225 1.00 8.34  ? 107 TYR C CA  1 
ATOM   4679 C C   . TYR C 3 107 ? 210.347 284.166 355.427 1.00 3.99  ? 107 TYR C C   1 
ATOM   4680 O O   . TYR C 3 107 ? 209.533 283.861 356.300 1.00 13.11 ? 107 TYR C O   1 
ATOM   4681 C CB  . TYR C 3 107 ? 211.429 282.308 354.127 1.00 0.59  ? 107 TYR C CB  1 
ATOM   4682 C CG  . TYR C 3 107 ? 212.736 281.695 353.686 1.00 12.70 ? 107 TYR C CG  1 
ATOM   4683 C CD1 . TYR C 3 107 ? 213.472 282.260 352.653 1.00 3.27  ? 107 TYR C CD1 1 
ATOM   4684 C CD2 . TYR C 3 107 ? 213.251 280.569 354.320 1.00 0.01  ? 107 TYR C CD2 1 
ATOM   4685 C CE1 . TYR C 3 107 ? 214.673 281.716 352.254 1.00 7.08  ? 107 TYR C CE1 1 
ATOM   4686 C CE2 . TYR C 3 107 ? 214.450 280.019 353.926 1.00 5.43  ? 107 TYR C CE2 1 
ATOM   4687 C CZ  . TYR C 3 107 ? 215.156 280.595 352.892 1.00 4.90  ? 107 TYR C CZ  1 
ATOM   4688 O OH  . TYR C 3 107 ? 216.352 280.054 352.500 1.00 14.99 ? 107 TYR C OH  1 
ATOM   4689 N N   . THR C 3 108 ? 210.198 285.218 354.627 1.00 7.41  ? 108 THR C N   1 
ATOM   4690 C CA  . THR C 3 108 ? 209.034 286.087 354.722 1.00 10.39 ? 108 THR C CA  1 
ATOM   4691 C C   . THR C 3 108 ? 207.865 285.555 353.905 1.00 2.51  ? 108 THR C C   1 
ATOM   4692 O O   . THR C 3 108 ? 206.716 285.641 354.346 1.00 6.63  ? 108 THR C O   1 
ATOM   4693 C CB  . THR C 3 108 ? 209.389 287.504 354.257 1.00 8.21  ? 108 THR C CB  1 
ATOM   4694 O OG1 . THR C 3 108 ? 210.642 287.900 354.827 1.00 14.72 ? 108 THR C OG1 1 
ATOM   4695 C CG2 . THR C 3 108 ? 208.319 288.504 354.668 1.00 9.29  ? 108 THR C CG2 1 
ATOM   4696 N N   . HIS C 3 109 ? 208.134 284.996 352.729 1.00 6.29  ? 109 HIS C N   1 
ATOM   4697 C CA  . HIS C 3 109 ? 207.086 284.583 351.808 1.00 2.67  ? 109 HIS C CA  1 
ATOM   4698 C C   . HIS C 3 109 ? 207.124 283.075 351.614 1.00 1.42  ? 109 HIS C C   1 
ATOM   4699 O O   . HIS C 3 109 ? 208.202 282.481 351.545 1.00 15.51 ? 109 HIS C O   1 
ATOM   4700 C CB  . HIS C 3 109 ? 207.242 285.287 350.457 1.00 6.68  ? 109 HIS C CB  1 
ATOM   4701 C CG  . HIS C 3 109 ? 207.230 286.780 350.551 1.00 5.64  ? 109 HIS C CG  1 
ATOM   4702 N ND1 . HIS C 3 109 ? 207.787 287.592 349.587 1.00 3.56  ? 109 HIS C ND1 1 
ATOM   4703 C CD2 . HIS C 3 109 ? 206.728 287.609 351.496 1.00 3.07  ? 109 HIS C CD2 1 
ATOM   4704 C CE1 . HIS C 3 109 ? 207.630 288.855 349.936 1.00 5.96  ? 109 HIS C CE1 1 
ATOM   4705 N NE2 . HIS C 3 109 ? 206.990 288.893 351.090 1.00 7.98  ? 109 HIS C NE2 1 
ATOM   4706 N N   . TRP C 3 110 ? 205.946 282.463 351.510 1.00 14.41 ? 110 TRP C N   1 
ATOM   4707 C CA  . TRP C 3 110 ? 205.844 281.042 351.215 1.00 10.03 ? 110 TRP C CA  1 
ATOM   4708 C C   . TRP C 3 110 ? 204.686 280.798 350.260 1.00 5.55  ? 110 TRP C C   1 
ATOM   4709 O O   . TRP C 3 110 ? 203.689 281.523 350.267 1.00 6.84  ? 110 TRP C O   1 
ATOM   4710 C CB  . TRP C 3 110 ? 205.658 280.208 352.490 1.00 6.93  ? 110 TRP C CB  1 
ATOM   4711 C CG  . TRP C 3 110 ? 204.283 280.271 353.093 1.00 5.44  ? 110 TRP C CG  1 
ATOM   4712 C CD1 . TRP C 3 110 ? 203.839 281.151 354.033 1.00 7.19  ? 110 TRP C CD1 1 
ATOM   4713 C CD2 . TRP C 3 110 ? 203.181 279.400 352.808 1.00 4.79  ? 110 TRP C CD2 1 
ATOM   4714 N NE1 . TRP C 3 110 ? 202.529 280.885 354.351 1.00 4.07  ? 110 TRP C NE1 1 
ATOM   4715 C CE2 . TRP C 3 110 ? 202.101 279.817 353.610 1.00 6.38  ? 110 TRP C CE2 1 
ATOM   4716 C CE3 . TRP C 3 110 ? 203.000 278.313 351.948 1.00 2.23  ? 110 TRP C CE3 1 
ATOM   4717 C CZ2 . TRP C 3 110 ? 200.860 279.184 353.580 1.00 3.38  ? 110 TRP C CZ2 1 
ATOM   4718 C CZ3 . TRP C 3 110 ? 201.770 277.686 351.920 1.00 7.86  ? 110 TRP C CZ3 1 
ATOM   4719 C CH2 . TRP C 3 110 ? 200.716 278.123 352.731 1.00 7.06  ? 110 TRP C CH2 1 
ATOM   4720 N N   . ALA C 3 111 ? 204.834 279.768 349.430 1.00 5.31  ? 111 ALA C N   1 
ATOM   4721 C CA  . ALA C 3 111 ? 203.760 279.338 348.549 1.00 8.99  ? 111 ALA C CA  1 
ATOM   4722 C C   . ALA C 3 111 ? 203.905 277.845 348.294 1.00 12.09 ? 111 ALA C C   1 
ATOM   4723 O O   . ALA C 3 111 ? 204.989 277.277 348.427 1.00 15.56 ? 111 ALA C O   1 
ATOM   4724 C CB  . ALA C 3 111 ? 203.764 280.112 347.225 1.00 7.73  ? 111 ALA C CB  1 
ATOM   4725 N N   . GLY C 3 112 ? 202.798 277.218 347.925 1.00 9.88  ? 112 GLY C N   1 
ATOM   4726 C CA  . GLY C 3 112 ? 202.780 275.812 347.580 1.00 14.60 ? 112 GLY C CA  1 
ATOM   4727 C C   . GLY C 3 112 ? 201.773 275.028 348.403 1.00 4.52  ? 112 GLY C C   1 
ATOM   4728 O O   . GLY C 3 112 ? 201.155 275.528 349.340 1.00 10.27 ? 112 GLY C O   1 
ATOM   4729 N N   . SER C 3 113 ? 201.623 273.768 348.011 1.00 10.84 ? 113 SER C N   1 
ATOM   4730 C CA  . SER C 3 113 ? 200.705 272.856 348.669 1.00 9.05  ? 113 SER C CA  1 
ATOM   4731 C C   . SER C 3 113 ? 201.352 272.251 349.909 1.00 6.52  ? 113 SER C C   1 
ATOM   4732 O O   . SER C 3 113 ? 202.575 272.235 350.059 1.00 13.83 ? 113 SER C O   1 
ATOM   4733 C CB  . SER C 3 113 ? 200.277 271.747 347.711 1.00 6.34  ? 113 SER C CB  1 
ATOM   4734 O OG  . SER C 3 113 ? 199.763 272.289 346.511 1.00 16.05 ? 113 SER C OG  1 
ATOM   4735 N N   . LEU C 3 114 ? 200.509 271.756 350.807 1.00 11.25 ? 114 LEU C N   1 
ATOM   4736 C CA  . LEU C 3 114 ? 200.968 271.110 352.027 1.00 14.53 ? 114 LEU C CA  1 
ATOM   4737 C C   . LEU C 3 114 ? 200.395 269.702 352.104 1.00 8.84  ? 114 LEU C C   1 
ATOM   4738 O O   . LEU C 3 114 ? 199.360 269.407 351.510 1.00 15.63 ? 114 LEU C O   1 
ATOM   4739 C CB  . LEU C 3 114 ? 200.565 271.917 353.266 1.00 11.56 ? 114 LEU C CB  1 
ATOM   4740 C CG  . LEU C 3 114 ? 201.216 273.297 353.371 1.00 14.66 ? 114 LEU C CG  1 
ATOM   4741 C CD1 . LEU C 3 114 ? 200.541 274.142 354.432 1.00 16.38 ? 114 LEU C CD1 1 
ATOM   4742 C CD2 . LEU C 3 114 ? 202.695 273.157 353.665 1.00 13.87 ? 114 LEU C CD2 1 
ATOM   4743 N N   . LYS C 3 115 ? 201.091 268.825 352.818 1.00 11.89 ? 115 LYS C N   1 
ATOM   4744 C CA  . LYS C 3 115 ? 200.632 267.467 353.080 1.00 8.36  ? 115 LYS C CA  1 
ATOM   4745 C C   . LYS C 3 115 ? 200.405 267.325 354.573 1.00 5.73  ? 115 LYS C C   1 
ATOM   4746 O O   . LYS C 3 115 ? 201.324 267.561 355.364 1.00 17.53 ? 115 LYS C O   1 
ATOM   4747 C CB  . LYS C 3 115 ? 201.650 266.430 352.607 1.00 9.04  ? 115 LYS C CB  1 
ATOM   4748 C CG  . LYS C 3 115 ? 201.464 265.972 351.182 1.00 16.11 ? 115 LYS C CG  1 
ATOM   4749 C CD  . LYS C 3 115 ? 202.358 264.782 350.856 1.00 15.15 ? 115 LYS C CD  1 
ATOM   4750 C CE  . LYS C 3 115 ? 203.833 265.112 351.026 1.00 18.55 ? 115 LYS C CE  1 
ATOM   4751 N NZ  . LYS C 3 115 ? 204.224 266.318 350.249 1.00 20.55 ? 115 LYS C NZ  1 
ATOM   4752 N N   . PHE C 3 116 ? 199.192 266.946 354.958 1.00 6.43  ? 116 PHE C N   1 
ATOM   4753 C CA  . PHE C 3 116 ? 198.870 266.621 356.341 1.00 5.51  ? 116 PHE C CA  1 
ATOM   4754 C C   . PHE C 3 116 ? 198.558 265.134 356.401 1.00 5.36  ? 116 PHE C C   1 
ATOM   4755 O O   . PHE C 3 116 ? 197.555 264.680 355.843 1.00 20.17 ? 116 PHE C O   1 
ATOM   4756 C CB  . PHE C 3 116 ? 197.702 267.458 356.853 1.00 5.83  ? 116 PHE C CB  1 
ATOM   4757 C CG  . PHE C 3 116 ? 198.045 268.901 357.067 1.00 11.29 ? 116 PHE C CG  1 
ATOM   4758 C CD1 . PHE C 3 116 ? 198.554 269.332 358.280 1.00 5.82  ? 116 PHE C CD1 1 
ATOM   4759 C CD2 . PHE C 3 116 ? 197.868 269.827 356.053 1.00 8.48  ? 116 PHE C CD2 1 
ATOM   4760 C CE1 . PHE C 3 116 ? 198.876 270.658 358.480 1.00 8.89  ? 116 PHE C CE1 1 
ATOM   4761 C CE2 . PHE C 3 116 ? 198.188 271.156 356.248 1.00 12.64 ? 116 PHE C CE2 1 
ATOM   4762 C CZ  . PHE C 3 116 ? 198.693 271.570 357.463 1.00 10.98 ? 116 PHE C CZ  1 
ATOM   4763 N N   . THR C 3 117 ? 199.428 264.381 357.055 1.00 4.45  ? 117 THR C N   1 
ATOM   4764 C CA  . THR C 3 117 ? 199.221 262.961 357.273 1.00 8.56  ? 117 THR C CA  1 
ATOM   4765 C C   . THR C 3 117 ? 198.764 262.742 358.707 1.00 7.64  ? 117 THR C C   1 
ATOM   4766 O O   . THR C 3 117 ? 199.203 263.436 359.623 1.00 13.09 ? 117 THR C O   1 
ATOM   4767 C CB  . THR C 3 117 ? 200.499 262.164 356.997 1.00 10.66 ? 117 THR C CB  1 
ATOM   4768 O OG1 . THR C 3 117 ? 200.860 262.300 355.618 1.00 17.79 ? 117 THR C OG1 1 
ATOM   4769 C CG2 . THR C 3 117 ? 200.295 260.690 357.315 1.00 11.82 ? 117 THR C CG2 1 
ATOM   4770 N N   . PHE C 3 118 ? 197.855 261.800 358.891 1.00 12.48 ? 118 PHE C N   1 
ATOM   4771 C CA  . PHE C 3 118 ? 197.377 261.436 360.213 1.00 9.09  ? 118 PHE C CA  1 
ATOM   4772 C C   . PHE C 3 118 ? 197.529 259.936 360.382 1.00 8.39  ? 118 PHE C C   1 
ATOM   4773 O O   . PHE C 3 118 ? 197.137 259.164 359.501 1.00 21.49 ? 118 PHE C O   1 
ATOM   4774 C CB  . PHE C 3 118 ? 195.928 261.877 360.418 1.00 8.91  ? 118 PHE C CB  1 
ATOM   4775 C CG  . PHE C 3 118 ? 195.763 263.365 360.497 1.00 9.92  ? 118 PHE C CG  1 
ATOM   4776 C CD1 . PHE C 3 118 ? 196.020 264.040 361.678 1.00 11.02 ? 118 PHE C CD1 1 
ATOM   4777 C CD2 . PHE C 3 118 ? 195.361 264.093 359.390 1.00 10.95 ? 118 PHE C CD2 1 
ATOM   4778 C CE1 . PHE C 3 118 ? 195.875 265.409 361.755 1.00 12.53 ? 118 PHE C CE1 1 
ATOM   4779 C CE2 . PHE C 3 118 ? 195.211 265.463 359.462 1.00 11.31 ? 118 PHE C CE2 1 
ATOM   4780 C CZ  . PHE C 3 118 ? 195.468 266.121 360.646 1.00 12.38 ? 118 PHE C CZ  1 
ATOM   4781 N N   . LEU C 3 119 ? 198.116 259.538 361.502 1.00 5.04  ? 119 LEU C N   1 
ATOM   4782 C CA  . LEU C 3 119 ? 198.382 258.144 361.816 1.00 9.55  ? 119 LEU C CA  1 
ATOM   4783 C C   . LEU C 3 119 ? 197.510 257.726 362.989 1.00 6.16  ? 119 LEU C C   1 
ATOM   4784 O O   . LEU C 3 119 ? 197.540 258.360 364.048 1.00 8.95  ? 119 LEU C O   1 
ATOM   4785 C CB  . LEU C 3 119 ? 199.860 257.934 362.151 1.00 2.41  ? 119 LEU C CB  1 
ATOM   4786 C CG  . LEU C 3 119 ? 200.269 256.504 362.502 1.00 11.32 ? 119 LEU C CG  1 
ATOM   4787 C CD1 . LEU C 3 119 ? 200.085 255.585 361.304 1.00 11.68 ? 119 LEU C CD1 1 
ATOM   4788 C CD2 . LEU C 3 119 ? 201.703 256.470 362.997 1.00 14.34 ? 119 LEU C CD2 1 
ATOM   4789 N N   . PHE C 3 120 ? 196.734 256.667 362.791 1.00 9.40  ? 120 PHE C N   1 
ATOM   4790 C CA  . PHE C 3 120 ? 195.888 256.112 363.837 1.00 9.66  ? 120 PHE C CA  1 
ATOM   4791 C C   . PHE C 3 120 ? 196.682 255.079 364.627 1.00 4.35  ? 120 PHE C C   1 
ATOM   4792 O O   . PHE C 3 120 ? 197.251 254.149 364.048 1.00 14.24 ? 120 PHE C O   1 
ATOM   4793 C CB  . PHE C 3 120 ? 194.635 255.488 363.222 1.00 6.70  ? 120 PHE C CB  1 
ATOM   4794 C CG  . PHE C 3 120 ? 193.734 254.819 364.214 1.00 7.89  ? 120 PHE C CG  1 
ATOM   4795 C CD1 . PHE C 3 120 ? 192.851 255.558 364.977 1.00 5.96  ? 120 PHE C CD1 1 
ATOM   4796 C CD2 . PHE C 3 120 ? 193.759 253.444 364.370 1.00 6.61  ? 120 PHE C CD2 1 
ATOM   4797 C CE1 . PHE C 3 120 ? 192.015 254.941 365.883 1.00 12.05 ? 120 PHE C CE1 1 
ATOM   4798 C CE2 . PHE C 3 120 ? 192.923 252.823 365.275 1.00 11.35 ? 120 PHE C CE2 1 
ATOM   4799 C CZ  . PHE C 3 120 ? 192.052 253.573 366.031 1.00 7.88  ? 120 PHE C CZ  1 
ATOM   4800 N N   . CYS C 3 121 ? 196.724 255.251 365.947 1.00 4.91  ? 121 CYS C N   1 
ATOM   4801 C CA  . CYS C 3 121 ? 197.540 254.410 366.814 1.00 8.70  ? 121 CYS C CA  1 
ATOM   4802 C C   . CYS C 3 121 ? 196.702 253.580 367.779 1.00 7.46  ? 121 CYS C C   1 
ATOM   4803 O O   . CYS C 3 121 ? 197.207 253.150 368.820 1.00 20.02 ? 121 CYS C O   1 
ATOM   4804 C CB  . CYS C 3 121 ? 198.546 255.265 367.585 1.00 11.74 ? 121 CYS C CB  1 
ATOM   4805 S SG  . CYS C 3 121 ? 199.736 256.119 366.531 1.00 18.08 ? 121 CYS C SG  1 
ATOM   4806 N N   . GLY C 3 122 ? 195.437 253.338 367.454 1.00 10.82 ? 122 GLY C N   1 
ATOM   4807 C CA  . GLY C 3 122 ? 194.611 252.448 368.235 1.00 11.44 ? 122 GLY C CA  1 
ATOM   4808 C C   . GLY C 3 122 ? 194.934 250.996 367.944 1.00 6.27  ? 122 GLY C C   1 
ATOM   4809 O O   . GLY C 3 122 ? 195.879 250.660 367.229 1.00 7.38  ? 122 GLY C O   1 
ATOM   4810 N N   . SER C 3 123 ? 194.122 250.118 368.520 1.00 9.14  ? 123 SER C N   1 
ATOM   4811 C CA  . SER C 3 123 ? 194.323 248.692 368.334 1.00 8.05  ? 123 SER C CA  1 
ATOM   4812 C C   . SER C 3 123 ? 193.933 248.278 366.918 1.00 5.69  ? 123 SER C C   1 
ATOM   4813 O O   . SER C 3 123 ? 193.241 249.000 366.195 1.00 8.47  ? 123 SER C O   1 
ATOM   4814 C CB  . SER C 3 123 ? 193.508 247.896 369.352 1.00 9.45  ? 123 SER C CB  1 
ATOM   4815 O OG  . SER C 3 123 ? 192.123 247.994 369.084 1.00 14.25 ? 123 SER C OG  1 
ATOM   4816 N N   . MET C 3 124 ? 194.396 247.093 366.524 1.00 12.23 ? 124 MET C N   1 
ATOM   4817 C CA  . MET C 3 124 ? 194.004 246.550 365.230 1.00 12.99 ? 124 MET C CA  1 
ATOM   4818 C C   . MET C 3 124 ? 192.509 246.259 365.185 1.00 7.69  ? 124 MET C C   1 
ATOM   4819 O O   . MET C 3 124 ? 191.908 246.263 364.107 1.00 11.43 ? 124 MET C O   1 
ATOM   4820 C CB  . MET C 3 124 ? 194.811 245.286 364.934 1.00 4.12  ? 124 MET C CB  1 
ATOM   4821 C CG  . MET C 3 124 ? 194.550 244.662 363.568 1.00 18.56 ? 124 MET C CG  1 
ATOM   4822 S SD  . MET C 3 124 ? 195.091 245.680 362.178 1.00 41.62 ? 124 MET C SD  1 
ATOM   4823 C CE  . MET C 3 124 ? 193.610 246.613 361.799 1.00 20.24 ? 124 MET C CE  1 
ATOM   4824 N N   . MET C 3 125 ? 191.890 246.020 366.341 1.00 7.74  ? 125 MET C N   1 
ATOM   4825 C CA  . MET C 3 125 ? 190.468 245.709 366.400 1.00 10.83 ? 125 MET C CA  1 
ATOM   4826 C C   . MET C 3 125 ? 189.579 246.943 366.291 1.00 10.82 ? 125 MET C C   1 
ATOM   4827 O O   . MET C 3 125 ? 188.367 246.792 366.111 1.00 18.49 ? 125 MET C O   1 
ATOM   4828 C CB  . MET C 3 125 ? 190.157 244.960 367.699 1.00 7.68  ? 125 MET C CB  1 
ATOM   4829 C CG  . MET C 3 125 ? 190.716 243.543 367.732 1.00 12.55 ? 125 MET C CG  1 
ATOM   4830 S SD  . MET C 3 125 ? 189.926 242.472 366.516 1.00 20.52 ? 125 MET C SD  1 
ATOM   4831 C CE  . MET C 3 125 ? 190.930 240.997 366.631 1.00 15.91 ? 125 MET C CE  1 
ATOM   4832 N N   . ALA C 3 126 ? 190.138 248.146 366.387 1.00 10.61 ? 126 ALA C N   1 
ATOM   4833 C CA  . ALA C 3 126 ? 189.342 249.359 366.286 1.00 10.38 ? 126 ALA C CA  1 
ATOM   4834 C C   . ALA C 3 126 ? 189.020 249.671 364.831 1.00 10.17 ? 126 ALA C C   1 
ATOM   4835 O O   . ALA C 3 126 ? 189.869 249.530 363.947 1.00 18.29 ? 126 ALA C O   1 
ATOM   4836 C CB  . ALA C 3 126 ? 190.078 250.540 366.918 1.00 8.69  ? 126 ALA C CB  1 
ATOM   4837 N N   . THR C 3 127 ? 187.782 250.087 364.589 1.00 5.81  ? 127 THR C N   1 
ATOM   4838 C CA  . THR C 3 127 ? 187.338 250.524 363.276 1.00 12.31 ? 127 THR C CA  1 
ATOM   4839 C C   . THR C 3 127 ? 186.750 251.920 363.399 1.00 11.89 ? 127 THR C C   1 
ATOM   4840 O O   . THR C 3 127 ? 186.344 252.352 364.479 1.00 10.64 ? 127 THR C O   1 
ATOM   4841 C CB  . THR C 3 127 ? 186.284 249.582 362.671 1.00 11.02 ? 127 THR C CB  1 
ATOM   4842 O OG1 . THR C 3 127 ? 185.056 249.703 363.398 1.00 17.31 ? 127 THR C OG1 1 
ATOM   4843 C CG2 . THR C 3 127 ? 186.758 248.140 362.714 1.00 14.14 ? 127 THR C CG2 1 
ATOM   4844 N N   . GLY C 3 128 ? 186.704 252.622 362.276 1.00 8.27  ? 128 GLY C N   1 
ATOM   4845 C CA  . GLY C 3 128 ? 186.108 253.939 362.264 1.00 8.62  ? 128 GLY C CA  1 
ATOM   4846 C C   . GLY C 3 128 ? 186.336 254.683 360.971 1.00 7.59  ? 128 GLY C C   1 
ATOM   4847 O O   . GLY C 3 128 ? 187.206 254.320 360.175 1.00 8.23  ? 128 GLY C O   1 
ATOM   4848 N N   . LYS C 3 129 ? 185.550 255.724 360.747 1.00 9.80  ? 129 LYS C N   1 
ATOM   4849 C CA  . LYS C 3 129 ? 185.759 256.626 359.630 1.00 7.05  ? 129 LYS C CA  1 
ATOM   4850 C C   . LYS C 3 129 ? 185.804 258.051 360.153 1.00 5.16  ? 129 LYS C C   1 
ATOM   4851 O O   . LYS C 3 129 ? 185.009 258.435 361.015 1.00 10.88 ? 129 LYS C O   1 
ATOM   4852 C CB  . LYS C 3 129 ? 184.665 256.470 358.568 1.00 6.76  ? 129 LYS C CB  1 
ATOM   4853 C CG  . LYS C 3 129 ? 184.722 255.140 357.832 1.00 8.48  ? 129 LYS C CG  1 
ATOM   4854 C CD  . LYS C 3 129 ? 183.501 254.934 356.958 1.00 16.73 ? 129 LYS C CD  1 
ATOM   4855 C CE  . LYS C 3 129 ? 183.429 253.516 356.404 1.00 14.47 ? 129 LYS C CE  1 
ATOM   4856 N NZ  . LYS C 3 129 ? 184.533 253.215 355.458 1.00 15.29 ? 129 LYS C NZ  1 
ATOM   4857 N N   . LEU C 3 130 ? 186.750 258.820 359.633 1.00 8.90  ? 130 LEU C N   1 
ATOM   4858 C CA  . LEU C 3 130 ? 186.932 260.216 359.984 1.00 7.93  ? 130 LEU C CA  1 
ATOM   4859 C C   . LEU C 3 130 ? 186.852 261.062 358.722 1.00 7.19  ? 130 LEU C C   1 
ATOM   4860 O O   . LEU C 3 130 ? 187.038 260.573 357.609 1.00 8.89  ? 130 LEU C O   1 
ATOM   4861 C CB  . LEU C 3 130 ? 188.280 260.443 360.683 1.00 11.72 ? 130 LEU C CB  1 
ATOM   4862 C CG  . LEU C 3 130 ? 188.549 259.556 361.900 1.00 8.35  ? 130 LEU C CG  1 
ATOM   4863 C CD1 . LEU C 3 130 ? 189.947 259.798 362.444 1.00 11.26 ? 130 LEU C CD1 1 
ATOM   4864 C CD2 . LEU C 3 130 ? 187.503 259.790 362.976 1.00 4.90  ? 130 LEU C CD2 1 
ATOM   4865 N N   . LEU C 3 131 ? 186.560 262.339 358.908 1.00 13.30 ? 131 LEU C N   1 
ATOM   4866 C CA  . LEU C 3 131 ? 186.547 263.311 357.828 1.00 4.83  ? 131 LEU C CA  1 
ATOM   4867 C C   . LEU C 3 131 ? 187.588 264.374 358.138 1.00 9.75  ? 131 LEU C C   1 
ATOM   4868 O O   . LEU C 3 131 ? 187.580 264.957 359.225 1.00 9.94  ? 131 LEU C O   1 
ATOM   4869 C CB  . LEU C 3 131 ? 185.159 263.935 357.666 1.00 11.64 ? 131 LEU C CB  1 
ATOM   4870 C CG  . LEU C 3 131 ? 184.948 264.797 356.421 1.00 6.77  ? 131 LEU C CG  1 
ATOM   4871 C CD1 . LEU C 3 131 ? 183.485 264.771 356.008 1.00 12.92 ? 131 LEU C CD1 1 
ATOM   4872 C CD2 . LEU C 3 131 ? 185.413 266.230 356.658 1.00 11.37 ? 131 LEU C CD2 1 
ATOM   4873 N N   . VAL C 3 132 ? 188.488 264.611 357.191 1.00 8.14  ? 132 VAL C N   1 
ATOM   4874 C CA  . VAL C 3 132 ? 189.545 265.605 357.329 1.00 10.84 ? 132 VAL C CA  1 
ATOM   4875 C C   . VAL C 3 132 ? 189.285 266.679 356.287 1.00 6.87  ? 132 VAL C C   1 
ATOM   4876 O O   . VAL C 3 132 ? 189.241 266.384 355.089 1.00 11.55 ? 132 VAL C O   1 
ATOM   4877 C CB  . VAL C 3 132 ? 190.936 264.980 357.148 1.00 9.15  ? 132 VAL C CB  1 
ATOM   4878 C CG1 . VAL C 3 132 ? 192.024 265.997 357.459 1.00 13.22 ? 132 VAL C CG1 1 
ATOM   4879 C CG2 . VAL C 3 132 ? 191.080 263.750 358.024 1.00 14.38 ? 132 VAL C CG2 1 
ATOM   4880 N N   . SER C 3 133 ? 189.124 267.921 356.733 1.00 9.55  ? 133 SER C N   1 
ATOM   4881 C CA  . SER C 3 133 ? 188.637 268.986 355.871 1.00 9.16  ? 133 SER C CA  1 
ATOM   4882 C C   . SER C 3 133 ? 189.577 270.180 355.886 1.00 10.64 ? 133 SER C C   1 
ATOM   4883 O O   . SER C 3 133 ? 190.084 270.579 356.938 1.00 14.80 ? 133 SER C O   1 
ATOM   4884 C CB  . SER C 3 133 ? 187.242 269.438 356.302 1.00 7.17  ? 133 SER C CB  1 
ATOM   4885 O OG  . SER C 3 133 ? 187.268 269.928 357.627 1.00 19.03 ? 133 SER C OG  1 
ATOM   4886 N N   . TYR C 3 134 ? 189.795 270.740 354.701 1.00 8.80  ? 134 TYR C N   1 
ATOM   4887 C CA  . TYR C 3 134 ? 190.391 272.052 354.512 1.00 7.99  ? 134 TYR C CA  1 
ATOM   4888 C C   . TYR C 3 134 ? 189.328 272.984 353.942 1.00 2.91  ? 134 TYR C C   1 
ATOM   4889 O O   . TYR C 3 134 ? 188.755 272.710 352.881 1.00 9.67  ? 134 TYR C O   1 
ATOM   4890 C CB  . TYR C 3 134 ? 191.598 271.981 353.580 1.00 4.41  ? 134 TYR C CB  1 
ATOM   4891 C CG  . TYR C 3 134 ? 192.082 273.334 353.117 1.00 10.26 ? 134 TYR C CG  1 
ATOM   4892 C CD1 . TYR C 3 134 ? 192.553 274.272 354.026 1.00 10.11 ? 134 TYR C CD1 1 
ATOM   4893 C CD2 . TYR C 3 134 ? 192.068 273.676 351.772 1.00 11.74 ? 134 TYR C CD2 1 
ATOM   4894 C CE1 . TYR C 3 134 ? 192.994 275.508 353.611 1.00 7.31  ? 134 TYR C CE1 1 
ATOM   4895 C CE2 . TYR C 3 134 ? 192.516 274.912 351.346 1.00 4.99  ? 134 TYR C CE2 1 
ATOM   4896 C CZ  . TYR C 3 134 ? 192.976 275.823 352.271 1.00 9.33  ? 134 TYR C CZ  1 
ATOM   4897 O OH  . TYR C 3 134 ? 193.420 277.056 351.864 1.00 15.93 ? 134 TYR C OH  1 
ATOM   4898 N N   . ALA C 3 135 ? 189.068 274.071 354.656 1.00 3.35  ? 135 ALA C N   1 
ATOM   4899 C CA  . ALA C 3 135 ? 188.166 275.122 354.207 1.00 5.86  ? 135 ALA C CA  1 
ATOM   4900 C C   . ALA C 3 135 ? 188.985 276.349 353.831 1.00 10.48 ? 135 ALA C C   1 
ATOM   4901 O O   . ALA C 3 135 ? 189.613 276.956 354.712 1.00 9.58  ? 135 ALA C O   1 
ATOM   4902 C CB  . ALA C 3 135 ? 187.156 275.472 355.300 1.00 6.33  ? 135 ALA C CB  1 
ATOM   4903 N N   . PRO C 3 136 ? 189.029 276.747 352.563 1.00 9.23  ? 136 PRO C N   1 
ATOM   4904 C CA  . PRO C 3 136 ? 189.664 278.021 352.212 1.00 5.14  ? 136 PRO C CA  1 
ATOM   4905 C C   . PRO C 3 136 ? 189.049 279.159 353.005 1.00 2.45  ? 136 PRO C C   1 
ATOM   4906 O O   . PRO C 3 136 ? 187.895 279.063 353.445 1.00 13.75 ? 136 PRO C O   1 
ATOM   4907 C CB  . PRO C 3 136 ? 189.377 278.156 350.710 1.00 9.03  ? 136 PRO C CB  1 
ATOM   4908 C CG  . PRO C 3 136 ? 189.240 276.761 350.235 1.00 11.93 ? 136 PRO C CG  1 
ATOM   4909 C CD  . PRO C 3 136 ? 188.622 275.990 351.367 1.00 6.33  ? 136 PRO C CD  1 
ATOM   4910 N N   . PRO C 3 137 ? 189.785 280.241 353.226 1.00 11.47 ? 137 PRO C N   1 
ATOM   4911 C CA  . PRO C 3 137 ? 189.338 281.284 354.156 1.00 5.89  ? 137 PRO C CA  1 
ATOM   4912 C C   . PRO C 3 137 ? 188.249 282.165 353.548 1.00 0.01  ? 137 PRO C C   1 
ATOM   4913 O O   . PRO C 3 137 ? 187.862 282.021 352.393 1.00 7.59  ? 137 PRO C O   1 
ATOM   4914 C CB  . PRO C 3 137 ? 190.619 282.074 354.425 1.00 8.93  ? 137 PRO C CB  1 
ATOM   4915 C CG  . PRO C 3 137 ? 191.426 281.905 353.200 1.00 0.60  ? 137 PRO C CG  1 
ATOM   4916 C CD  . PRO C 3 137 ? 191.101 280.551 352.642 1.00 8.17  ? 137 PRO C CD  1 
ATOM   4917 N N   . GLY C 3 138 ? 187.756 283.094 354.363 1.00 11.72 ? 138 GLY C N   1 
ATOM   4918 C CA  . GLY C 3 138 ? 186.736 284.039 353.956 1.00 5.21  ? 138 GLY C CA  1 
ATOM   4919 C C   . GLY C 3 138 ? 185.357 283.751 354.503 1.00 9.44  ? 138 GLY C C   1 
ATOM   4920 O O   . GLY C 3 138 ? 184.480 284.618 354.410 1.00 18.13 ? 138 GLY C O   1 
ATOM   4921 N N   . ALA C 3 139 ? 185.135 282.569 355.065 1.00 5.26  ? 139 ALA C N   1 
ATOM   4922 C CA  . ALA C 3 139 ? 183.877 282.206 355.695 1.00 10.80 ? 139 ALA C CA  1 
ATOM   4923 C C   . ALA C 3 139 ? 184.138 281.790 357.136 1.00 8.48  ? 139 ALA C C   1 
ATOM   4924 O O   . ALA C 3 139 ? 185.281 281.606 357.559 1.00 12.12 ? 139 ALA C O   1 
ATOM   4925 C CB  . ALA C 3 139 ? 183.179 281.075 354.928 1.00 3.92  ? 139 ALA C CB  1 
ATOM   4926 N N   . GLU C 3 140 ? 183.056 281.646 357.894 1.00 14.00 ? 140 GLU C N   1 
ATOM   4927 C CA  . GLU C 3 140 ? 183.171 281.193 359.273 1.00 16.90 ? 140 GLU C CA  1 
ATOM   4928 C C   . GLU C 3 140 ? 183.869 279.840 359.322 1.00 12.59 ? 140 GLU C C   1 
ATOM   4929 O O   . GLU C 3 140 ? 183.536 278.927 358.560 1.00 7.53  ? 140 GLU C O   1 
ATOM   4930 C CB  . GLU C 3 140 ? 181.785 281.101 359.907 1.00 13.79 ? 140 GLU C CB  1 
ATOM   4931 C CG  . GLU C 3 140 ? 181.798 280.785 361.388 1.00 16.41 ? 140 GLU C CG  1 
ATOM   4932 C CD  . GLU C 3 140 ? 180.404 280.628 361.956 1.00 22.72 ? 140 GLU C CD  1 
ATOM   4933 O OE1 . GLU C 3 140 ? 179.430 280.725 361.181 1.00 26.43 ? 140 GLU C OE1 1 
ATOM   4934 O OE2 . GLU C 3 140 ? 180.279 280.408 363.178 1.00 27.48 ? 140 GLU C OE2 1 
ATOM   4935 N N   . ALA C 3 141 ? 184.840 279.713 360.220 1.00 12.22 ? 141 ALA C N   1 
ATOM   4936 C CA  . ALA C 3 141 ? 185.578 278.465 360.329 1.00 13.41 ? 141 ALA C CA  1 
ATOM   4937 C C   . ALA C 3 141 ? 184.614 277.329 360.666 1.00 9.60  ? 141 ALA C C   1 
ATOM   4938 O O   . ALA C 3 141 ? 183.724 277.504 361.506 1.00 14.86 ? 141 ALA C O   1 
ATOM   4939 C CB  . ALA C 3 141 ? 186.667 278.576 361.397 1.00 9.96  ? 141 ALA C CB  1 
ATOM   4940 N N   . PRO C 3 142 ? 184.749 276.162 360.034 1.00 14.45 ? 142 PRO C N   1 
ATOM   4941 C CA  . PRO C 3 142 ? 183.734 275.108 360.204 1.00 14.25 ? 142 PRO C CA  1 
ATOM   4942 C C   . PRO C 3 142 ? 183.525 274.749 361.666 1.00 11.80 ? 142 PRO C C   1 
ATOM   4943 O O   . PRO C 3 142 ? 184.436 274.275 362.346 1.00 18.12 ? 142 PRO C O   1 
ATOM   4944 C CB  . PRO C 3 142 ? 184.310 273.931 359.406 1.00 14.48 ? 142 PRO C CB  1 
ATOM   4945 C CG  . PRO C 3 142 ? 185.252 274.543 358.444 1.00 18.43 ? 142 PRO C CG  1 
ATOM   4946 C CD  . PRO C 3 142 ? 185.834 275.733 359.135 1.00 11.10 ? 142 PRO C CD  1 
ATOM   4947 N N   . LYS C 3 143 ? 182.307 274.990 362.150 1.00 14.93 ? 143 LYS C N   1 
ATOM   4948 C CA  . LYS C 3 143 ? 181.966 274.644 363.523 1.00 18.55 ? 143 LYS C CA  1 
ATOM   4949 C C   . LYS C 3 143 ? 181.582 273.178 363.661 1.00 14.39 ? 143 LYS C C   1 
ATOM   4950 O O   . LYS C 3 143 ? 181.770 272.591 364.730 1.00 23.83 ? 143 LYS C O   1 
ATOM   4951 C CB  . LYS C 3 143 ? 180.818 275.523 364.020 1.00 18.77 ? 143 LYS C CB  1 
ATOM   4952 C CG  . LYS C 3 143 ? 181.132 277.009 364.055 1.00 22.45 ? 143 LYS C CG  1 
ATOM   4953 C CD  . LYS C 3 143 ? 180.117 277.774 364.894 1.00 22.92 ? 143 LYS C CD  1 
ATOM   4954 C CE  . LYS C 3 143 ? 178.696 277.609 364.371 1.00 24.90 ? 143 LYS C CE  1 
ATOM   4955 N NZ  . LYS C 3 143 ? 178.553 278.041 362.954 1.00 26.32 ? 143 LYS C NZ  1 
ATOM   4956 N N   . SER C 3 144 ? 181.044 272.578 362.603 1.00 10.77 ? 144 SER C N   1 
ATOM   4957 C CA  . SER C 3 144 ? 180.584 271.200 362.637 1.00 12.32 ? 144 SER C CA  1 
ATOM   4958 C C   . SER C 3 144 ? 180.904 270.537 361.306 1.00 10.83 ? 144 SER C C   1 
ATOM   4959 O O   . SER C 3 144 ? 181.347 271.183 360.353 1.00 15.08 ? 144 SER C O   1 
ATOM   4960 C CB  . SER C 3 144 ? 179.082 271.117 362.928 1.00 13.48 ? 144 SER C CB  1 
ATOM   4961 O OG  . SER C 3 144 ? 178.324 271.469 361.786 1.00 19.17 ? 144 SER C OG  1 
ATOM   4962 N N   . ARG C 3 145 ? 180.664 269.227 361.251 1.00 8.79  ? 145 ARG C N   1 
ATOM   4963 C CA  . ARG C 3 145 ? 180.940 268.477 360.032 1.00 15.32 ? 145 ARG C CA  1 
ATOM   4964 C C   . ARG C 3 145 ? 180.091 268.966 358.866 1.00 10.28 ? 145 ARG C C   1 
ATOM   4965 O O   . ARG C 3 145 ? 180.525 268.894 357.713 1.00 9.62  ? 145 ARG C O   1 
ATOM   4966 C CB  . ARG C 3 145 ? 180.704 266.987 360.273 1.00 9.49  ? 145 ARG C CB  1 
ATOM   4967 C CG  . ARG C 3 145 ? 181.175 266.097 359.140 1.00 7.97  ? 145 ARG C CG  1 
ATOM   4968 C CD  . ARG C 3 145 ? 180.751 264.655 359.346 1.00 12.11 ? 145 ARG C CD  1 
ATOM   4969 N NE  . ARG C 3 145 ? 179.301 264.501 359.332 1.00 13.25 ? 145 ARG C NE  1 
ATOM   4970 C CZ  . ARG C 3 145 ? 178.669 263.337 359.390 1.00 7.42  ? 145 ARG C CZ  1 
ATOM   4971 N NH1 . ARG C 3 145 ? 179.329 262.193 359.457 1.00 14.99 ? 145 ARG C NH1 1 
ATOM   4972 N NH2 . ARG C 3 145 ? 177.340 263.320 359.378 1.00 8.61  ? 145 ARG C NH2 1 
ATOM   4973 N N   . LYS C 3 146 ? 178.892 269.485 359.142 1.00 11.86 ? 146 LYS C N   1 
ATOM   4974 C CA  . LYS C 3 146 ? 178.028 269.955 358.062 1.00 13.81 ? 146 LYS C CA  1 
ATOM   4975 C C   . LYS C 3 146 ? 178.697 271.066 357.262 1.00 13.02 ? 146 LYS C C   1 
ATOM   4976 O O   . LYS C 3 146 ? 178.628 271.077 356.028 1.00 19.79 ? 146 LYS C O   1 
ATOM   4977 C CB  . LYS C 3 146 ? 176.690 270.431 358.628 1.00 15.15 ? 146 LYS C CB  1 
ATOM   4978 C CG  . LYS C 3 146 ? 175.928 269.354 359.383 1.00 18.69 ? 146 LYS C CG  1 
ATOM   4979 C CD  . LYS C 3 146 ? 174.607 269.867 359.949 1.00 18.48 ? 146 LYS C CD  1 
ATOM   4980 C CE  . LYS C 3 146 ? 173.598 270.184 358.854 1.00 20.95 ? 146 LYS C CE  1 
ATOM   4981 N NZ  . LYS C 3 146 ? 173.310 269.006 357.991 1.00 22.45 ? 146 LYS C NZ  1 
ATOM   4982 N N   . GLU C 3 147 ? 179.345 272.012 357.945 1.00 12.41 ? 147 GLU C N   1 
ATOM   4983 C CA  . GLU C 3 147 ? 180.085 273.054 357.237 1.00 15.12 ? 147 GLU C CA  1 
ATOM   4984 C C   . GLU C 3 147 ? 181.390 272.519 356.661 1.00 12.77 ? 147 GLU C C   1 
ATOM   4985 O O   . GLU C 3 147 ? 181.748 272.840 355.523 1.00 18.16 ? 147 GLU C O   1 
ATOM   4986 C CB  . GLU C 3 147 ? 180.368 274.232 358.168 1.00 9.86  ? 147 GLU C CB  1 
ATOM   4987 C CG  . GLU C 3 147 ? 179.140 275.026 358.566 1.00 14.86 ? 147 GLU C CG  1 
ATOM   4988 C CD  . GLU C 3 147 ? 178.399 274.416 359.734 1.00 22.41 ? 147 GLU C CD  1 
ATOM   4989 O OE1 . GLU C 3 147 ? 178.833 273.357 360.233 1.00 29.41 ? 147 GLU C OE1 1 
ATOM   4990 O OE2 . GLU C 3 147 ? 177.380 274.998 360.158 1.00 30.61 ? 147 GLU C OE2 1 
ATOM   4991 N N   . ALA C 3 148 ? 182.115 271.706 357.431 1.00 9.10  ? 148 ALA C N   1 
ATOM   4992 C CA  . ALA C 3 148 ? 183.441 271.270 357.004 1.00 12.04 ? 148 ALA C CA  1 
ATOM   4993 C C   . ALA C 3 148 ? 183.371 270.450 355.723 1.00 11.30 ? 148 ALA C C   1 
ATOM   4994 O O   . ALA C 3 148 ? 184.250 270.554 354.860 1.00 14.35 ? 148 ALA C O   1 
ATOM   4995 C CB  . ALA C 3 148 ? 184.108 270.468 358.119 1.00 10.63 ? 148 ALA C CB  1 
ATOM   4996 N N   . MET C 3 149 ? 182.330 269.632 355.580 1.00 6.80  ? 149 MET C N   1 
ATOM   4997 C CA  . MET C 3 149 ? 182.187 268.775 354.411 1.00 7.10  ? 149 MET C CA  1 
ATOM   4998 C C   . MET C 3 149 ? 181.993 269.570 353.123 1.00 8.21  ? 149 MET C C   1 
ATOM   4999 O O   . MET C 3 149 ? 182.167 269.013 352.035 1.00 7.03  ? 149 MET C O   1 
ATOM   5000 C CB  . MET C 3 149 ? 181.020 267.813 354.647 1.00 11.67 ? 149 MET C CB  1 
ATOM   5001 C CG  . MET C 3 149 ? 180.359 267.267 353.405 1.00 17.92 ? 149 MET C CG  1 
ATOM   5002 S SD  . MET C 3 149 ? 179.119 268.384 352.714 1.00 23.49 ? 149 MET C SD  1 
ATOM   5003 C CE  . MET C 3 149 ? 177.844 268.338 353.964 1.00 11.82 ? 149 MET C CE  1 
ATOM   5004 N N   . LEU C 3 150 ? 181.648 270.855 353.219 1.00 5.19  ? 150 LEU C N   1 
ATOM   5005 C CA  . LEU C 3 150 ? 181.494 271.678 352.025 1.00 10.90 ? 150 LEU C CA  1 
ATOM   5006 C C   . LEU C 3 150 ? 182.835 272.070 351.418 1.00 10.43 ? 150 LEU C C   1 
ATOM   5007 O O   . LEU C 3 150 ? 182.912 272.317 350.211 1.00 16.51 ? 150 LEU C O   1 
ATOM   5008 C CB  . LEU C 3 150 ? 180.678 272.928 352.358 1.00 4.60  ? 150 LEU C CB  1 
ATOM   5009 C CG  . LEU C 3 150 ? 179.268 272.631 352.878 1.00 13.39 ? 150 LEU C CG  1 
ATOM   5010 C CD1 . LEU C 3 150 ? 178.570 273.900 353.333 1.00 6.13  ? 150 LEU C CD1 1 
ATOM   5011 C CD2 . LEU C 3 150 ? 178.444 271.917 351.817 1.00 10.90 ? 150 LEU C CD2 1 
ATOM   5012 N N   . GLY C 3 151 ? 183.889 272.137 352.225 1.00 5.44  ? 151 GLY C N   1 
ATOM   5013 C CA  . GLY C 3 151 ? 185.217 272.415 351.727 1.00 8.86  ? 151 GLY C CA  1 
ATOM   5014 C C   . GLY C 3 151 ? 185.896 271.164 351.205 1.00 8.03  ? 151 GLY C C   1 
ATOM   5015 O O   . GLY C 3 151 ? 185.316 270.080 351.131 1.00 15.13 ? 151 GLY C O   1 
ATOM   5016 N N   . THR C 3 152 ? 187.160 271.330 350.830 1.00 15.26 ? 152 THR C N   1 
ATOM   5017 C CA  . THR C 3 152 ? 187.961 270.182 350.431 1.00 9.52  ? 152 THR C CA  1 
ATOM   5018 C C   . THR C 3 152 ? 188.019 269.196 351.588 1.00 9.38  ? 152 THR C C   1 
ATOM   5019 O O   . THR C 3 152 ? 188.147 269.593 352.743 1.00 14.83 ? 152 THR C O   1 
ATOM   5020 C CB  . THR C 3 152 ? 189.372 270.629 350.041 1.00 8.39  ? 152 THR C CB  1 
ATOM   5021 O OG1 . THR C 3 152 ? 189.295 271.589 348.982 1.00 23.16 ? 152 THR C OG1 1 
ATOM   5022 C CG2 . THR C 3 152 ? 190.216 269.446 349.588 1.00 11.11 ? 152 THR C CG2 1 
ATOM   5023 N N   . HIS C 3 153 ? 187.886 267.907 351.298 1.00 7.66  ? 153 HIS C N   1 
ATOM   5024 C CA  . HIS C 3 153 ? 187.944 266.960 352.401 1.00 13.01 ? 153 HIS C CA  1 
ATOM   5025 C C   . HIS C 3 153 ? 188.222 265.554 351.896 1.00 7.94  ? 153 HIS C C   1 
ATOM   5026 O O   . HIS C 3 153 ? 188.098 265.253 350.707 1.00 14.82 ? 153 HIS C O   1 
ATOM   5027 C CB  . HIS C 3 153 ? 186.656 266.984 353.234 1.00 7.53  ? 153 HIS C CB  1 
ATOM   5028 C CG  . HIS C 3 153 ? 185.462 266.430 352.524 1.00 11.72 ? 153 HIS C CG  1 
ATOM   5029 N ND1 . HIS C 3 153 ? 184.713 267.171 351.637 1.00 15.39 ? 153 HIS C ND1 1 
ATOM   5030 C CD2 . HIS C 3 153 ? 184.881 265.208 352.578 1.00 14.93 ? 153 HIS C CD2 1 
ATOM   5031 C CE1 . HIS C 3 153 ? 183.723 266.430 351.173 1.00 11.00 ? 153 HIS C CE1 1 
ATOM   5032 N NE2 . HIS C 3 153 ? 183.804 265.234 351.727 1.00 14.23 ? 153 HIS C NE2 1 
ATOM   5033 N N   . VAL C 3 154 ? 188.605 264.705 352.843 1.00 10.62 ? 154 VAL C N   1 
ATOM   5034 C CA  . VAL C 3 154 ? 188.941 263.309 352.609 1.00 11.05 ? 154 VAL C CA  1 
ATOM   5035 C C   . VAL C 3 154 ? 188.272 262.473 353.690 1.00 8.75  ? 154 VAL C C   1 
ATOM   5036 O O   . VAL C 3 154 ? 188.241 262.866 354.862 1.00 12.45 ? 154 VAL C O   1 
ATOM   5037 C CB  . VAL C 3 154 ? 190.469 263.081 352.621 1.00 15.20 ? 154 VAL C CB  1 
ATOM   5038 C CG1 . VAL C 3 154 ? 190.788 261.597 352.582 1.00 13.80 ? 154 VAL C CG1 1 
ATOM   5039 C CG2 . VAL C 3 154 ? 191.132 263.803 351.457 1.00 17.30 ? 154 VAL C CG2 1 
ATOM   5040 N N   . ILE C 3 155 ? 187.731 261.325 353.297 1.00 12.00 ? 155 ILE C N   1 
ATOM   5041 C CA  . ILE C 3 155 ? 187.182 260.351 354.233 1.00 11.75 ? 155 ILE C CA  1 
ATOM   5042 C C   . ILE C 3 155 ? 188.243 259.286 354.473 1.00 9.12  ? 155 ILE C C   1 
ATOM   5043 O O   . ILE C 3 155 ? 188.742 258.666 353.528 1.00 21.69 ? 155 ILE C O   1 
ATOM   5044 C CB  . ILE C 3 155 ? 185.877 259.732 353.707 1.00 10.52 ? 155 ILE C CB  1 
ATOM   5045 C CG1 . ILE C 3 155 ? 184.887 260.827 353.299 1.00 12.96 ? 155 ILE C CG1 1 
ATOM   5046 C CG2 . ILE C 3 155 ? 185.259 258.834 354.763 1.00 12.26 ? 155 ILE C CG2 1 
ATOM   5047 C CD1 . ILE C 3 155 ? 184.542 261.801 354.405 1.00 13.20 ? 155 ILE C CD1 1 
ATOM   5048 N N   . TRP C 3 156 ? 188.581 259.076 355.739 1.00 11.93 ? 156 TRP C N   1 
ATOM   5049 C CA  . TRP C 3 156 ? 189.660 258.195 356.164 1.00 15.05 ? 156 TRP C CA  1 
ATOM   5050 C C   . TRP C 3 156 ? 189.057 257.014 356.910 1.00 6.83  ? 156 TRP C C   1 
ATOM   5051 O O   . TRP C 3 156 ? 188.410 257.200 357.943 1.00 7.59  ? 156 TRP C O   1 
ATOM   5052 C CB  . TRP C 3 156 ? 190.637 258.960 357.058 1.00 8.28  ? 156 TRP C CB  1 
ATOM   5053 C CG  . TRP C 3 156 ? 191.695 258.136 357.735 1.00 10.40 ? 156 TRP C CG  1 
ATOM   5054 C CD1 . TRP C 3 156 ? 192.130 256.893 357.380 1.00 9.59  ? 156 TRP C CD1 1 
ATOM   5055 C CD2 . TRP C 3 156 ? 192.455 258.511 358.889 1.00 9.71  ? 156 TRP C CD2 1 
ATOM   5056 N NE1 . TRP C 3 156 ? 193.114 256.473 358.239 1.00 18.85 ? 156 TRP C NE1 1 
ATOM   5057 C CE2 . TRP C 3 156 ? 193.332 257.449 359.175 1.00 10.54 ? 156 TRP C CE2 1 
ATOM   5058 C CE3 . TRP C 3 156 ? 192.478 259.644 359.709 1.00 12.48 ? 156 TRP C CE3 1 
ATOM   5059 C CZ2 . TRP C 3 156 ? 194.221 257.483 360.246 1.00 11.36 ? 156 TRP C CZ2 1 
ATOM   5060 C CZ3 . TRP C 3 156 ? 193.360 259.676 360.771 1.00 16.16 ? 156 TRP C CZ3 1 
ATOM   5061 C CH2 . TRP C 3 156 ? 194.220 258.602 361.031 1.00 9.28  ? 156 TRP C CH2 1 
ATOM   5062 N N   . ASP C 3 157 ? 189.274 255.809 356.394 1.00 7.95  ? 157 ASP C N   1 
ATOM   5063 C CA  . ASP C 3 157 ? 188.832 254.581 357.051 1.00 14.39 ? 157 ASP C CA  1 
ATOM   5064 C C   . ASP C 3 157 ? 190.009 254.047 357.861 1.00 7.64  ? 157 ASP C C   1 
ATOM   5065 O O   . ASP C 3 157 ? 190.962 253.501 357.303 1.00 14.06 ? 157 ASP C O   1 
ATOM   5066 C CB  . ASP C 3 157 ? 188.338 253.566 356.025 1.00 11.64 ? 157 ASP C CB  1 
ATOM   5067 C CG  . ASP C 3 157 ? 187.580 252.414 356.659 1.00 16.14 ? 157 ASP C CG  1 
ATOM   5068 O OD1 . ASP C 3 157 ? 187.999 251.935 357.731 1.00 23.70 ? 157 ASP C OD1 1 
ATOM   5069 O OD2 . ASP C 3 157 ? 186.559 251.989 356.083 1.00 22.33 ? 157 ASP C OD2 1 
ATOM   5070 N N   . ILE C 3 158 ? 189.946 254.219 359.184 1.00 10.52 ? 158 ILE C N   1 
ATOM   5071 C CA  . ILE C 3 158 ? 191.063 253.816 360.033 1.00 12.39 ? 158 ILE C CA  1 
ATOM   5072 C C   . ILE C 3 158 ? 191.211 252.301 360.049 1.00 16.38 ? 158 ILE C C   1 
ATOM   5073 O O   . ILE C 3 158 ? 192.321 251.782 360.208 1.00 28.70 ? 158 ILE C O   1 
ATOM   5074 C CB  . ILE C 3 158 ? 190.905 254.378 361.460 1.00 14.61 ? 158 ILE C CB  1 
ATOM   5075 C CG1 . ILE C 3 158 ? 189.605 253.893 362.104 1.00 19.30 ? 158 ILE C CG1 1 
ATOM   5076 C CG2 . ILE C 3 158 ? 190.943 255.896 361.432 1.00 12.68 ? 158 ILE C CG2 1 
ATOM   5077 C CD1 . ILE C 3 158 ? 189.575 254.034 363.610 1.00 20.10 ? 158 ILE C CD1 1 
ATOM   5078 N N   . GLY C 3 159 ? 190.108 251.568 359.896 1.00 19.78 ? 159 GLY C N   1 
ATOM   5079 C CA  . GLY C 3 159 ? 190.208 250.121 359.820 1.00 17.34 ? 159 GLY C CA  1 
ATOM   5080 C C   . GLY C 3 159 ? 191.041 249.664 358.640 1.00 18.27 ? 159 GLY C C   1 
ATOM   5081 O O   . GLY C 3 159 ? 191.845 248.737 358.756 1.00 25.53 ? 159 GLY C O   1 
ATOM   5082 N N   . LEU C 3 160 ? 190.873 250.319 357.491 1.00 22.16 ? 160 LEU C N   1 
ATOM   5083 C CA  . LEU C 3 160 ? 191.596 249.932 356.286 1.00 19.00 ? 160 LEU C CA  1 
ATOM   5084 C C   . LEU C 3 160 ? 193.055 250.375 356.344 1.00 21.56 ? 160 LEU C C   1 
ATOM   5085 O O   . LEU C 3 160 ? 193.969 249.544 356.330 1.00 29.84 ? 160 LEU C O   1 
ATOM   5086 C CB  . LEU C 3 160 ? 190.901 250.524 355.056 1.00 21.99 ? 160 LEU C CB  1 
ATOM   5087 C CG  . LEU C 3 160 ? 191.696 250.538 353.747 1.00 24.20 ? 160 LEU C CG  1 
ATOM   5088 C CD1 . LEU C 3 160 ? 192.119 249.129 353.348 1.00 25.45 ? 160 LEU C CD1 1 
ATOM   5089 C CD2 . LEU C 3 160 ? 190.883 251.189 352.643 1.00 23.13 ? 160 LEU C CD2 1 
ATOM   5090 N N   . GLN C 3 161 ? 193.292 251.683 356.415 1.00 19.94 ? 161 GLN C N   1 
ATOM   5091 C CA  . GLN C 3 161 ? 194.637 252.243 356.420 1.00 21.64 ? 161 GLN C CA  1 
ATOM   5092 C C   . GLN C 3 161 ? 194.861 253.019 357.709 1.00 17.69 ? 161 GLN C C   1 
ATOM   5093 O O   . GLN C 3 161 ? 194.081 253.916 358.043 1.00 21.45 ? 161 GLN C O   1 
ATOM   5094 C CB  . GLN C 3 161 ? 194.865 253.148 355.204 1.00 19.18 ? 161 GLN C CB  1 
ATOM   5095 C CG  . GLN C 3 161 ? 193.873 254.289 355.060 1.00 20.68 ? 161 GLN C CG  1 
ATOM   5096 C CD  . GLN C 3 161 ? 194.159 255.157 353.845 1.00 24.12 ? 161 GLN C CD  1 
ATOM   5097 O OE1 . GLN C 3 161 ? 194.740 254.697 352.863 1.00 28.97 ? 161 GLN C OE1 1 
ATOM   5098 N NE2 . GLN C 3 161 ? 193.758 256.419 353.911 1.00 21.85 ? 161 GLN C NE2 1 
ATOM   5099 N N   . SER C 3 162 ? 195.928 252.669 358.428 1.00 9.80  ? 162 SER C N   1 
ATOM   5100 C CA  . SER C 3 162 ? 196.267 253.375 359.656 1.00 13.74 ? 162 SER C CA  1 
ATOM   5101 C C   . SER C 3 162 ? 196.702 254.811 359.398 1.00 9.40  ? 162 SER C C   1 
ATOM   5102 O O   . SER C 3 162 ? 196.710 255.619 360.332 1.00 8.91  ? 162 SER C O   1 
ATOM   5103 C CB  . SER C 3 162 ? 197.377 252.628 360.399 1.00 9.71  ? 162 SER C CB  1 
ATOM   5104 O OG  . SER C 3 162 ? 196.936 251.352 360.821 1.00 21.37 ? 162 SER C OG  1 
ATOM   5105 N N   . SER C 3 163 ? 197.061 255.145 358.163 1.00 7.39  ? 163 SER C N   1 
ATOM   5106 C CA  . SER C 3 163 ? 197.549 256.470 357.819 1.00 15.47 ? 163 SER C CA  1 
ATOM   5107 C C   . SER C 3 163 ? 196.710 257.045 356.689 1.00 9.22  ? 163 SER C C   1 
ATOM   5108 O O   . SER C 3 163 ? 196.350 256.334 355.747 1.00 20.45 ? 163 SER C O   1 
ATOM   5109 C CB  . SER C 3 163 ? 199.025 256.425 357.408 1.00 11.48 ? 163 SER C CB  1 
ATOM   5110 O OG  . SER C 3 163 ? 199.486 257.706 357.025 1.00 20.16 ? 163 SER C OG  1 
ATOM   5111 N N   . CYS C 3 164 ? 196.393 258.332 356.794 1.00 11.69 ? 164 CYS C N   1 
ATOM   5112 C CA  . CYS C 3 164 ? 195.681 259.055 355.747 1.00 12.09 ? 164 CYS C CA  1 
ATOM   5113 C C   . CYS C 3 164 ? 196.395 260.363 355.455 1.00 9.83  ? 164 CYS C C   1 
ATOM   5114 O O   . CYS C 3 164 ? 196.710 261.117 356.378 1.00 16.04 ? 164 CYS C O   1 
ATOM   5115 C CB  . CYS C 3 164 ? 194.232 259.341 356.145 1.00 11.64 ? 164 CYS C CB  1 
ATOM   5116 S SG  . CYS C 3 164 ? 193.430 260.620 355.144 1.00 36.76 ? 164 CYS C SG  1 
ATOM   5117 N N   . THR C 3 165 ? 196.629 260.642 354.179 1.00 9.40  ? 165 THR C N   1 
ATOM   5118 C CA  . THR C 3 165 ? 197.254 261.884 353.749 1.00 13.29 ? 165 THR C CA  1 
ATOM   5119 C C   . THR C 3 165 ? 196.230 262.742 353.021 1.00 13.28 ? 165 THR C C   1 
ATOM   5120 O O   . THR C 3 165 ? 195.595 262.282 352.068 1.00 20.37 ? 165 THR C O   1 
ATOM   5121 C CB  . THR C 3 165 ? 198.453 261.611 352.839 1.00 10.61 ? 165 THR C CB  1 
ATOM   5122 O OG1 . THR C 3 165 ? 199.430 260.842 353.550 1.00 24.80 ? 165 THR C OG1 1 
ATOM   5123 C CG2 . THR C 3 165 ? 199.083 262.915 352.376 1.00 16.14 ? 165 THR C CG2 1 
ATOM   5124 N N   . MET C 3 166 ? 196.067 263.979 353.479 1.00 15.07 ? 166 MET C N   1 
ATOM   5125 C CA  . MET C 3 166 ? 195.280 264.986 352.781 1.00 11.86 ? 166 MET C CA  1 
ATOM   5126 C C   . MET C 3 166 ? 196.227 266.061 352.270 1.00 13.76 ? 166 MET C C   1 
ATOM   5127 O O   . MET C 3 166 ? 197.003 266.633 353.044 1.00 12.97 ? 166 MET C O   1 
ATOM   5128 C CB  . MET C 3 166 ? 194.216 265.601 353.691 1.00 10.41 ? 166 MET C CB  1 
ATOM   5129 C CG  . MET C 3 166 ? 193.278 266.555 352.953 1.00 16.63 ? 166 MET C CG  1 
ATOM   5130 S SD  . MET C 3 166 ? 191.982 267.284 353.973 1.00 30.62 ? 166 MET C SD  1 
ATOM   5131 C CE  . MET C 3 166 ? 192.920 268.468 354.928 1.00 14.69 ? 166 MET C CE  1 
ATOM   5132 N N   . VAL C 3 167 ? 196.168 266.327 350.974 1.00 15.76 ? 167 VAL C N   1 
ATOM   5133 C CA  . VAL C 3 167 ? 196.924 267.415 350.373 1.00 13.10 ? 167 VAL C CA  1 
ATOM   5134 C C   . VAL C 3 167 ? 196.070 268.672 350.423 1.00 7.60  ? 167 VAL C C   1 
ATOM   5135 O O   . VAL C 3 167 ? 194.947 268.693 349.907 1.00 17.84 ? 167 VAL C O   1 
ATOM   5136 C CB  . VAL C 3 167 ? 197.330 267.077 348.929 1.00 12.15 ? 167 VAL C CB  1 
ATOM   5137 C CG1 . VAL C 3 167 ? 198.025 268.268 348.282 1.00 14.80 ? 167 VAL C CG1 1 
ATOM   5138 C CG2 . VAL C 3 167 ? 198.229 265.847 348.901 1.00 14.37 ? 167 VAL C CG2 1 
ATOM   5139 N N   . VAL C 3 168 ? 196.587 269.705 351.077 1.00 13.04 ? 168 VAL C N   1 
ATOM   5140 C CA  . VAL C 3 168 ? 195.984 271.031 351.069 1.00 10.19 ? 168 VAL C CA  1 
ATOM   5141 C C   . VAL C 3 168 ? 196.575 271.763 349.870 1.00 5.54  ? 168 VAL C C   1 
ATOM   5142 O O   . VAL C 3 168 ? 197.719 272.240 349.940 1.00 12.84 ? 168 VAL C O   1 
ATOM   5143 C CB  . VAL C 3 168 ? 196.247 271.779 352.384 1.00 9.02  ? 168 VAL C CB  1 
ATOM   5144 C CG1 . VAL C 3 168 ? 195.608 273.159 352.346 1.00 9.04  ? 168 VAL C CG1 1 
ATOM   5145 C CG2 . VAL C 3 168 ? 195.731 270.971 353.569 1.00 7.33  ? 168 VAL C CG2 1 
ATOM   5146 N N   . PRO C 3 169 ? 195.861 271.844 348.747 1.00 7.76  ? 169 PRO C N   1 
ATOM   5147 C CA  . PRO C 3 169 ? 196.445 272.466 347.554 1.00 12.17 ? 169 PRO C CA  1 
ATOM   5148 C C   . PRO C 3 169 ? 196.628 273.959 347.749 1.00 5.90  ? 169 PRO C C   1 
ATOM   5149 O O   . PRO C 3 169 ? 195.880 274.606 348.486 1.00 1.30  ? 169 PRO C O   1 
ATOM   5150 C CB  . PRO C 3 169 ? 195.418 272.169 346.453 1.00 14.89 ? 169 PRO C CB  1 
ATOM   5151 C CG  . PRO C 3 169 ? 194.441 271.202 347.051 1.00 13.59 ? 169 PRO C CG  1 
ATOM   5152 C CD  . PRO C 3 169 ? 194.464 271.451 348.512 1.00 9.01  ? 169 PRO C CD  1 
ATOM   5153 N N   . TRP C 3 170 ? 197.632 274.506 347.073 1.00 15.51 ? 170 TRP C N   1 
ATOM   5154 C CA  . TRP C 3 170 ? 197.847 275.944 347.100 1.00 8.76  ? 170 TRP C CA  1 
ATOM   5155 C C   . TRP C 3 170 ? 196.658 276.657 346.471 1.00 10.47 ? 170 TRP C C   1 
ATOM   5156 O O   . TRP C 3 170 ? 196.432 276.550 345.263 1.00 15.15 ? 170 TRP C O   1 
ATOM   5157 C CB  . TRP C 3 170 ? 199.137 276.308 346.370 1.00 6.06  ? 170 TRP C CB  1 
ATOM   5158 C CG  . TRP C 3 170 ? 199.360 277.779 346.229 1.00 9.37  ? 170 TRP C CG  1 
ATOM   5159 C CD1 . TRP C 3 170 ? 199.290 278.508 345.081 1.00 14.50 ? 170 TRP C CD1 1 
ATOM   5160 C CD2 . TRP C 3 170 ? 199.695 278.702 347.272 1.00 9.06  ? 170 TRP C CD2 1 
ATOM   5161 N NE1 . TRP C 3 170 ? 199.565 279.828 345.341 1.00 16.32 ? 170 TRP C NE1 1 
ATOM   5162 C CE2 . TRP C 3 170 ? 199.817 279.974 346.679 1.00 10.83 ? 170 TRP C CE2 1 
ATOM   5163 C CE3 . TRP C 3 170 ? 199.905 278.578 348.649 1.00 9.11  ? 170 TRP C CE3 1 
ATOM   5164 C CZ2 . TRP C 3 170 ? 200.136 281.112 347.413 1.00 7.50  ? 170 TRP C CZ2 1 
ATOM   5165 C CZ3 . TRP C 3 170 ? 200.223 279.709 349.375 1.00 8.81  ? 170 TRP C CZ3 1 
ATOM   5166 C CH2 . TRP C 3 170 ? 200.336 280.959 348.755 1.00 4.02  ? 170 TRP C CH2 1 
ATOM   5167 N N   . ILE C 3 171 ? 195.880 277.359 347.287 1.00 7.49  ? 171 ILE C N   1 
ATOM   5168 C CA  . ILE C 3 171 ? 194.834 278.252 346.809 1.00 11.86 ? 171 ILE C CA  1 
ATOM   5169 C C   . ILE C 3 171 ? 194.968 279.563 347.567 1.00 9.53  ? 171 ILE C C   1 
ATOM   5170 O O   . ILE C 3 171 ? 194.870 279.588 348.799 1.00 5.17  ? 171 ILE C O   1 
ATOM   5171 C CB  . ILE C 3 171 ? 193.425 277.658 346.978 1.00 10.51 ? 171 ILE C CB  1 
ATOM   5172 C CG1 . ILE C 3 171 ? 192.383 278.657 346.475 1.00 14.98 ? 171 ILE C CG1 1 
ATOM   5173 C CG2 . ILE C 3 171 ? 193.159 277.286 348.430 1.00 11.47 ? 171 ILE C CG2 1 
ATOM   5174 C CD1 . ILE C 3 171 ? 191.042 278.050 346.217 1.00 15.55 ? 171 ILE C CD1 1 
ATOM   5175 N N   . SER C 3 172 ? 195.186 280.648 346.834 1.00 12.96 ? 172 SER C N   1 
ATOM   5176 C CA  . SER C 3 172 ? 195.512 281.924 347.445 1.00 11.87 ? 172 SER C CA  1 
ATOM   5177 C C   . SER C 3 172 ? 195.204 283.030 346.451 1.00 5.91  ? 172 SER C C   1 
ATOM   5178 O O   . SER C 3 172 ? 195.355 282.853 345.241 1.00 9.56  ? 172 SER C O   1 
ATOM   5179 C CB  . SER C 3 172 ? 196.988 281.973 347.863 1.00 9.11  ? 172 SER C CB  1 
ATOM   5180 O OG  . SER C 3 172 ? 197.300 283.173 348.546 1.00 14.09 ? 172 SER C OG  1 
ATOM   5181 N N   . ASN C 3 173 ? 194.760 284.170 346.974 1.00 9.41  ? 173 ASN C N   1 
ATOM   5182 C CA  . ASN C 3 173 ? 194.641 285.355 346.134 1.00 10.97 ? 173 ASN C CA  1 
ATOM   5183 C C   . ASN C 3 173 ? 196.021 285.874 345.742 1.00 11.27 ? 173 ASN C C   1 
ATOM   5184 O O   . ASN C 3 173 ? 196.275 286.166 344.569 1.00 20.57 ? 173 ASN C O   1 
ATOM   5185 C CB  . ASN C 3 173 ? 193.829 286.431 346.856 1.00 6.31  ? 173 ASN C CB  1 
ATOM   5186 C CG  . ASN C 3 173 ? 194.377 286.755 348.229 1.00 12.24 ? 173 ASN C CG  1 
ATOM   5187 O OD1 . ASN C 3 173 ? 195.019 285.922 348.864 1.00 14.11 ? 173 ASN C OD1 1 
ATOM   5188 N ND2 . ASN C 3 173 ? 194.130 287.971 348.692 1.00 14.65 ? 173 ASN C ND2 1 
ATOM   5189 N N   . THR C 3 174 ? 196.929 285.975 346.709 1.00 5.49  ? 174 THR C N   1 
ATOM   5190 C CA  . THR C 3 174 ? 198.297 286.390 346.434 1.00 7.82  ? 174 THR C CA  1 
ATOM   5191 C C   . THR C 3 174 ? 199.137 285.206 345.967 1.00 5.88  ? 174 THR C C   1 
ATOM   5192 O O   . THR C 3 174 ? 198.852 284.049 346.287 1.00 16.10 ? 174 THR C O   1 
ATOM   5193 C CB  . THR C 3 174 ? 198.937 287.013 347.676 1.00 10.78 ? 174 THR C CB  1 
ATOM   5194 O OG1 . THR C 3 174 ? 198.846 286.101 348.777 1.00 11.26 ? 174 THR C OG1 1 
ATOM   5195 C CG2 . THR C 3 174 ? 198.249 288.319 348.042 1.00 9.74  ? 174 THR C CG2 1 
ATOM   5196 N N   . THR C 3 175 ? 200.180 285.507 345.192 1.00 7.95  ? 175 THR C N   1 
ATOM   5197 C CA  . THR C 3 175 ? 201.089 284.458 344.744 1.00 8.97  ? 175 THR C CA  1 
ATOM   5198 C C   . THR C 3 175 ? 201.948 283.926 345.884 1.00 1.76  ? 175 THR C C   1 
ATOM   5199 O O   . THR C 3 175 ? 202.508 282.833 345.762 1.00 8.94  ? 175 THR C O   1 
ATOM   5200 C CB  . THR C 3 175 ? 201.991 284.967 343.615 1.00 7.35  ? 175 THR C CB  1 
ATOM   5201 O OG1 . THR C 3 175 ? 202.892 285.959 344.123 1.00 13.65 ? 175 THR C OG1 1 
ATOM   5202 C CG2 . THR C 3 175 ? 201.160 285.568 342.490 1.00 10.98 ? 175 THR C CG2 1 
ATOM   5203 N N   . TYR C 3 176 ? 202.072 284.675 346.975 1.00 5.28  ? 176 TYR C N   1 
ATOM   5204 C CA  . TYR C 3 176 ? 202.759 284.214 348.170 1.00 5.94  ? 176 TYR C CA  1 
ATOM   5205 C C   . TYR C 3 176 ? 202.005 284.690 349.399 1.00 8.03  ? 176 TYR C C   1 
ATOM   5206 O O   . TYR C 3 176 ? 201.427 285.778 349.408 1.00 14.76 ? 176 TYR C O   1 
ATOM   5207 C CB  . TYR C 3 176 ? 204.200 284.728 348.246 1.00 10.00 ? 176 TYR C CB  1 
ATOM   5208 C CG  . TYR C 3 176 ? 205.159 284.006 347.340 1.00 3.53  ? 176 TYR C CG  1 
ATOM   5209 C CD1 . TYR C 3 176 ? 205.842 282.881 347.778 1.00 0.87  ? 176 TYR C CD1 1 
ATOM   5210 C CD2 . TYR C 3 176 ? 205.387 284.451 346.048 1.00 1.34  ? 176 TYR C CD2 1 
ATOM   5211 C CE1 . TYR C 3 176 ? 206.721 282.218 346.953 1.00 8.22  ? 176 TYR C CE1 1 
ATOM   5212 C CE2 . TYR C 3 176 ? 206.260 283.797 345.217 1.00 7.29  ? 176 TYR C CE2 1 
ATOM   5213 C CZ  . TYR C 3 176 ? 206.925 282.681 345.671 1.00 4.53  ? 176 TYR C CZ  1 
ATOM   5214 O OH  . TYR C 3 176 ? 207.799 282.032 344.838 1.00 20.50 ? 176 TYR C OH  1 
ATOM   5215 N N   . ARG C 3 177 ? 202.035 283.872 350.439 1.00 4.07  ? 177 ARG C N   1 
ATOM   5216 C CA  . ARG C 3 177 ? 201.525 284.259 351.742 1.00 9.32  ? 177 ARG C CA  1 
ATOM   5217 C C   . ARG C 3 177 ? 202.678 284.684 352.641 1.00 8.31  ? 177 ARG C C   1 
ATOM   5218 O O   . ARG C 3 177 ? 203.800 284.188 352.520 1.00 10.98 ? 177 ARG C O   1 
ATOM   5219 C CB  . ARG C 3 177 ? 200.748 283.114 352.394 1.00 10.72 ? 177 ARG C CB  1 
ATOM   5220 C CG  . ARG C 3 177 ? 199.397 282.849 351.751 1.00 8.86  ? 177 ARG C CG  1 
ATOM   5221 C CD  . ARG C 3 177 ? 198.588 281.844 352.546 1.00 10.92 ? 177 ARG C CD  1 
ATOM   5222 N NE  . ARG C 3 177 ? 197.196 281.817 352.115 1.00 12.82 ? 177 ARG C NE  1 
ATOM   5223 C CZ  . ARG C 3 177 ? 196.672 280.924 351.285 1.00 9.74  ? 177 ARG C CZ  1 
ATOM   5224 N NH1 . ARG C 3 177 ? 197.389 279.929 350.791 1.00 9.17  ? 177 ARG C NH1 1 
ATOM   5225 N NH2 . ARG C 3 177 ? 195.388 281.026 350.954 1.00 12.23 ? 177 ARG C NH2 1 
ATOM   5226 N N   . LEU C 3 178 ? 202.391 285.621 353.534 1.00 10.08 ? 178 LEU C N   1 
ATOM   5227 C CA  . LEU C 3 178 ? 203.364 286.004 354.541 1.00 13.23 ? 178 LEU C CA  1 
ATOM   5228 C C   . LEU C 3 178 ? 203.504 284.896 355.578 1.00 13.41 ? 178 LEU C C   1 
ATOM   5229 O O   . LEU C 3 178 ? 202.581 284.113 355.814 1.00 12.69 ? 178 LEU C O   1 
ATOM   5230 C CB  . LEU C 3 178 ? 202.950 287.309 355.218 1.00 6.25  ? 178 LEU C CB  1 
ATOM   5231 C CG  . LEU C 3 178 ? 202.770 288.515 354.293 1.00 15.09 ? 178 LEU C CG  1 
ATOM   5232 C CD1 . LEU C 3 178 ? 202.297 289.722 355.082 1.00 12.20 ? 178 LEU C CD1 1 
ATOM   5233 C CD2 . LEU C 3 178 ? 204.056 288.832 353.547 1.00 14.23 ? 178 LEU C CD2 1 
ATOM   5234 N N   . THR C 3 179 ? 204.678 284.835 356.203 1.00 11.07 ? 179 THR C N   1 
ATOM   5235 C CA  . THR C 3 179 ? 204.952 283.862 357.249 1.00 6.65  ? 179 THR C CA  1 
ATOM   5236 C C   . THR C 3 179 ? 204.559 284.373 358.631 1.00 10.33 ? 179 THR C C   1 
ATOM   5237 O O   . THR C 3 179 ? 205.108 283.909 359.635 1.00 24.54 ? 179 THR C O   1 
ATOM   5238 C CB  . THR C 3 179 ? 206.430 283.465 357.226 1.00 4.60  ? 179 THR C CB  1 
ATOM   5239 O OG1 . THR C 3 179 ? 207.250 284.639 357.227 1.00 14.22 ? 179 THR C OG1 1 
ATOM   5240 C CG2 . THR C 3 179 ? 206.731 282.633 355.994 1.00 10.16 ? 179 THR C CG2 1 
ATOM   5241 N N   . ILE C 3 180 ? 203.621 285.315 358.698 1.00 9.43  ? 180 ILE C N   1 
ATOM   5242 C CA  . ILE C 3 180 ? 203.063 285.808 359.948 1.00 13.97 ? 180 ILE C CA  1 
ATOM   5243 C C   . ILE C 3 180 ? 201.550 285.647 359.885 1.00 12.41 ? 180 ILE C C   1 
ATOM   5244 O O   . ILE C 3 180 ? 200.970 285.427 358.823 1.00 19.55 ? 180 ILE C O   1 
ATOM   5245 C CB  . ILE C 3 180 ? 203.428 287.282 360.214 1.00 12.02 ? 180 ILE C CB  1 
ATOM   5246 C CG1 . ILE C 3 180 ? 202.947 288.166 359.057 1.00 13.63 ? 180 ILE C CG1 1 
ATOM   5247 C CG2 . ILE C 3 180 ? 204.920 287.430 360.407 1.00 16.92 ? 180 ILE C CG2 1 
ATOM   5248 C CD1 . ILE C 3 180 ? 203.094 289.650 359.309 1.00 17.07 ? 180 ILE C CD1 1 
ATOM   5249 N N   . ASN C 3 181 ? 200.912 285.768 361.044 1.00 15.18 ? 181 ASN C N   1 
ATOM   5250 C CA  . ASN C 3 181 ? 199.456 285.832 361.092 1.00 15.20 ? 181 ASN C CA  1 
ATOM   5251 C C   . ASN C 3 181 ? 199.006 287.105 360.385 1.00 14.93 ? 181 ASN C C   1 
ATOM   5252 O O   . ASN C 3 181 ? 199.241 288.213 360.877 1.00 21.75 ? 181 ASN C O   1 
ATOM   5253 C CB  . ASN C 3 181 ? 198.965 285.799 362.536 1.00 12.00 ? 181 ASN C CB  1 
ATOM   5254 C CG  . ASN C 3 181 ? 199.163 284.444 363.190 1.00 24.36 ? 181 ASN C CG  1 
ATOM   5255 O OD1 . ASN C 3 181 ? 199.025 283.401 362.548 1.00 23.91 ? 181 ASN C OD1 1 
ATOM   5256 N ND2 . ASN C 3 181 ? 199.490 284.452 364.477 1.00 22.37 ? 181 ASN C ND2 1 
ATOM   5257 N N   . ASP C 3 182 ? 198.370 286.952 359.227 1.00 17.70 ? 182 ASP C N   1 
ATOM   5258 C CA  . ASP C 3 182 ? 197.974 288.084 358.401 1.00 16.63 ? 182 ASP C CA  1 
ATOM   5259 C C   . ASP C 3 182 ? 196.610 287.804 357.791 1.00 16.11 ? 182 ASP C C   1 
ATOM   5260 O O   . ASP C 3 182 ? 196.417 286.769 357.148 1.00 19.95 ? 182 ASP C O   1 
ATOM   5261 C CB  . ASP C 3 182 ? 199.007 288.343 357.299 1.00 14.82 ? 182 ASP C CB  1 
ATOM   5262 C CG  . ASP C 3 182 ? 198.684 289.568 356.475 1.00 16.65 ? 182 ASP C CG  1 
ATOM   5263 O OD1 . ASP C 3 182 ? 198.747 290.686 357.024 1.00 22.78 ? 182 ASP C OD1 1 
ATOM   5264 O OD2 . ASP C 3 182 ? 198.370 289.413 355.278 1.00 21.31 ? 182 ASP C OD2 1 
ATOM   5265 N N   . SER C 3 183 ? 195.671 288.732 357.989 1.00 15.70 ? 183 SER C N   1 
ATOM   5266 C CA  . SER C 3 183 ? 194.310 288.519 357.507 1.00 13.10 ? 183 SER C CA  1 
ATOM   5267 C C   . SER C 3 183 ? 194.261 288.448 355.987 1.00 12.92 ? 183 SER C C   1 
ATOM   5268 O O   . SER C 3 183 ? 193.546 287.615 355.421 1.00 14.79 ? 183 SER C O   1 
ATOM   5269 C CB  . SER C 3 183 ? 193.393 289.631 358.015 1.00 18.88 ? 183 SER C CB  1 
ATOM   5270 O OG  . SER C 3 183 ? 193.302 289.599 359.425 1.00 27.90 ? 183 SER C OG  1 
ATOM   5271 N N   . PHE C 3 184 ? 195.014 289.314 355.307 1.00 11.38 ? 184 PHE C N   1 
ATOM   5272 C CA  . PHE C 3 184 ? 194.935 289.360 353.852 1.00 10.68 ? 184 PHE C CA  1 
ATOM   5273 C C   . PHE C 3 184 ? 195.467 288.078 353.222 1.00 10.12 ? 184 PHE C C   1 
ATOM   5274 O O   . PHE C 3 184 ? 194.952 287.633 352.191 1.00 17.35 ? 184 PHE C O   1 
ATOM   5275 C CB  . PHE C 3 184 ? 195.696 290.573 353.321 1.00 14.32 ? 184 PHE C CB  1 
ATOM   5276 C CG  . PHE C 3 184 ? 195.530 290.783 351.849 1.00 15.08 ? 184 PHE C CG  1 
ATOM   5277 C CD1 . PHE C 3 184 ? 194.362 291.330 351.343 1.00 11.80 ? 184 PHE C CD1 1 
ATOM   5278 C CD2 . PHE C 3 184 ? 196.532 290.428 350.967 1.00 13.37 ? 184 PHE C CD2 1 
ATOM   5279 C CE1 . PHE C 3 184 ? 194.202 291.519 349.989 1.00 14.77 ? 184 PHE C CE1 1 
ATOM   5280 C CE2 . PHE C 3 184 ? 196.375 290.616 349.609 1.00 14.35 ? 184 PHE C CE2 1 
ATOM   5281 C CZ  . PHE C 3 184 ? 195.210 291.165 349.120 1.00 15.10 ? 184 PHE C CZ  1 
ATOM   5282 N N   . THR C 3 185 ? 196.498 287.475 353.815 1.00 12.72 ? 185 THR C N   1 
ATOM   5283 C CA  . THR C 3 185 ? 197.085 286.242 353.303 1.00 12.00 ? 185 THR C CA  1 
ATOM   5284 C C   . THR C 3 185 ? 196.761 285.042 354.190 1.00 10.63 ? 185 THR C C   1 
ATOM   5285 O O   . THR C 3 185 ? 197.522 284.074 354.235 1.00 14.11 ? 185 THR C O   1 
ATOM   5286 C CB  . THR C 3 185 ? 198.599 286.390 353.142 1.00 16.75 ? 185 THR C CB  1 
ATOM   5287 O OG1 . THR C 3 185 ? 199.200 286.680 354.410 1.00 18.81 ? 185 THR C OG1 1 
ATOM   5288 C CG2 . THR C 3 185 ? 198.926 287.503 352.152 1.00 13.64 ? 185 THR C CG2 1 
ATOM   5289 N N   . GLU C 3 186 ? 195.637 285.093 354.899 1.00 13.64 ? 186 GLU C N   1 
ATOM   5290 C CA  . GLU C 3 186 ? 195.207 283.947 355.689 1.00 12.45 ? 186 GLU C CA  1 
ATOM   5291 C C   . GLU C 3 186 ? 195.005 282.738 354.785 1.00 7.17  ? 186 GLU C C   1 
ATOM   5292 O O   . GLU C 3 186 ? 194.568 282.865 353.638 1.00 13.97 ? 186 GLU C O   1 
ATOM   5293 C CB  . GLU C 3 186 ? 193.916 284.276 356.436 1.00 8.02  ? 186 GLU C CB  1 
ATOM   5294 C CG  . GLU C 3 186 ? 192.759 284.655 355.529 1.00 15.72 ? 186 GLU C CG  1 
ATOM   5295 C CD  . GLU C 3 186 ? 191.559 285.157 356.300 1.00 23.54 ? 186 GLU C CD  1 
ATOM   5296 O OE1 . GLU C 3 186 ? 191.554 285.029 357.541 1.00 25.35 ? 186 GLU C OE1 1 
ATOM   5297 O OE2 . GLU C 3 186 ? 190.620 285.680 355.666 1.00 23.92 ? 186 GLU C OE2 1 
ATOM   5298 N N   . GLY C 3 187 ? 195.336 281.559 355.304 1.00 7.02  ? 187 GLY C N   1 
ATOM   5299 C CA  . GLY C 3 187 ? 195.391 280.363 354.488 1.00 7.57  ? 187 GLY C CA  1 
ATOM   5300 C C   . GLY C 3 187 ? 194.220 279.411 354.621 1.00 9.33  ? 187 GLY C C   1 
ATOM   5301 O O   . GLY C 3 187 ? 194.152 278.420 353.891 1.00 14.81 ? 187 GLY C O   1 
ATOM   5302 N N   . GLY C 3 188 ? 193.305 279.680 355.538 1.00 8.45  ? 188 GLY C N   1 
ATOM   5303 C CA  . GLY C 3 188 ? 192.134 278.851 355.723 1.00 10.18 ? 188 GLY C CA  1 
ATOM   5304 C C   . GLY C 3 188 ? 192.190 278.022 356.992 1.00 10.18 ? 188 GLY C C   1 
ATOM   5305 O O   . GLY C 3 188 ? 192.919 278.318 357.941 1.00 17.69 ? 188 GLY C O   1 
ATOM   5306 N N   . TYR C 3 189 ? 191.398 276.953 356.999 1.00 9.78  ? 189 TYR C N   1 
ATOM   5307 C CA  . TYR C 3 189 ? 191.148 276.176 358.205 1.00 14.37 ? 189 TYR C CA  1 
ATOM   5308 C C   . TYR C 3 189 ? 191.275 274.687 357.920 1.00 6.43  ? 189 TYR C C   1 
ATOM   5309 O O   . TYR C 3 189 ? 190.900 274.219 356.845 1.00 15.22 ? 189 TYR C O   1 
ATOM   5310 C CB  . TYR C 3 189 ? 189.757 276.478 358.761 1.00 10.00 ? 189 TYR C CB  1 
ATOM   5311 C CG  . TYR C 3 189 ? 189.509 277.950 358.993 1.00 8.30  ? 189 TYR C CG  1 
ATOM   5312 C CD1 . TYR C 3 189 ? 190.151 278.627 360.022 1.00 8.59  ? 189 TYR C CD1 1 
ATOM   5313 C CD2 . TYR C 3 189 ? 188.638 278.663 358.183 1.00 8.70  ? 189 TYR C CD2 1 
ATOM   5314 C CE1 . TYR C 3 189 ? 189.933 279.970 360.236 1.00 8.71  ? 189 TYR C CE1 1 
ATOM   5315 C CE2 . TYR C 3 189 ? 188.410 280.008 358.391 1.00 12.94 ? 189 TYR C CE2 1 
ATOM   5316 C CZ  . TYR C 3 189 ? 189.060 280.656 359.418 1.00 10.32 ? 189 TYR C CZ  1 
ATOM   5317 O OH  . TYR C 3 189 ? 188.838 281.994 359.628 1.00 21.25 ? 189 TYR C OH  1 
ATOM   5318 N N   . ILE C 3 190 ? 191.789 273.948 358.898 1.00 6.85  ? 190 ILE C N   1 
ATOM   5319 C CA  . ILE C 3 190 ? 191.894 272.497 358.854 1.00 5.29  ? 190 ILE C CA  1 
ATOM   5320 C C   . ILE C 3 190 ? 191.142 271.955 360.058 1.00 0.39  ? 190 ILE C C   1 
ATOM   5321 O O   . ILE C 3 190 ? 191.340 272.430 361.182 1.00 15.63 ? 190 ILE C O   1 
ATOM   5322 C CB  . ILE C 3 190 ? 193.360 272.020 358.881 1.00 7.92  ? 190 ILE C CB  1 
ATOM   5323 C CG1 . ILE C 3 190 ? 194.148 272.569 357.686 1.00 12.30 ? 190 ILE C CG1 1 
ATOM   5324 C CG2 . ILE C 3 190 ? 193.420 270.500 358.917 1.00 9.11  ? 190 ILE C CG2 1 
ATOM   5325 C CD1 . ILE C 3 190 ? 193.669 272.073 356.346 1.00 12.74 ? 190 ILE C CD1 1 
ATOM   5326 N N   . SER C 3 191 ? 190.281 270.970 359.826 1.00 8.05  ? 191 SER C N   1 
ATOM   5327 C CA  . SER C 3 191 ? 189.492 270.389 360.900 1.00 12.08 ? 191 SER C CA  1 
ATOM   5328 C C   . SER C 3 191 ? 189.352 268.890 360.685 1.00 9.43  ? 191 SER C C   1 
ATOM   5329 O O   . SER C 3 191 ? 189.482 268.383 359.569 1.00 11.74 ? 191 SER C O   1 
ATOM   5330 C CB  . SER C 3 191 ? 188.109 271.043 360.998 1.00 9.94  ? 191 SER C CB  1 
ATOM   5331 O OG  . SER C 3 191 ? 187.436 270.995 359.754 1.00 19.38 ? 191 SER C OG  1 
ATOM   5332 N N   . MET C 3 192 ? 189.104 268.181 361.780 1.00 12.10 ? 192 MET C N   1 
ATOM   5333 C CA  . MET C 3 192 ? 188.845 266.749 361.725 1.00 7.08  ? 192 MET C CA  1 
ATOM   5334 C C   . MET C 3 192 ? 187.566 266.441 362.489 1.00 7.33  ? 192 MET C C   1 
ATOM   5335 O O   . MET C 3 192 ? 187.322 266.999 363.561 1.00 12.54 ? 192 MET C O   1 
ATOM   5336 C CB  . MET C 3 192 ? 190.016 265.938 362.297 1.00 5.65  ? 192 MET C CB  1 
ATOM   5337 C CG  . MET C 3 192 ? 189.878 264.437 362.083 1.00 11.70 ? 192 MET C CG  1 
ATOM   5338 S SD  . MET C 3 192 ? 191.253 263.477 362.739 1.00 20.02 ? 192 MET C SD  1 
ATOM   5339 C CE  . MET C 3 192 ? 192.560 263.925 361.603 1.00 10.16 ? 192 MET C CE  1 
ATOM   5340 N N   . PHE C 3 193 ? 186.753 265.552 361.921 1.00 6.81  ? 193 PHE C N   1 
ATOM   5341 C CA  . PHE C 3 193 ? 185.472 265.164 362.492 1.00 5.71  ? 193 PHE C CA  1 
ATOM   5342 C C   . PHE C 3 193 ? 185.335 263.652 362.416 1.00 5.71  ? 193 PHE C C   1 
ATOM   5343 O O   . PHE C 3 193 ? 186.018 262.989 361.638 1.00 7.73  ? 193 PHE C O   1 
ATOM   5344 C CB  . PHE C 3 193 ? 184.293 265.818 361.753 1.00 5.81  ? 193 PHE C CB  1 
ATOM   5345 C CG  . PHE C 3 193 ? 184.292 267.315 361.815 1.00 5.77  ? 193 PHE C CG  1 
ATOM   5346 C CD1 . PHE C 3 193 ? 185.090 268.059 360.963 1.00 9.88  ? 193 PHE C CD1 1 
ATOM   5347 C CD2 . PHE C 3 193 ? 183.489 267.979 362.721 1.00 8.87  ? 193 PHE C CD2 1 
ATOM   5348 C CE1 . PHE C 3 193 ? 185.090 269.433 361.024 1.00 10.94 ? 193 PHE C CE1 1 
ATOM   5349 C CE2 . PHE C 3 193 ? 183.487 269.354 362.786 1.00 10.20 ? 193 PHE C CE2 1 
ATOM   5350 C CZ  . PHE C 3 193 ? 184.286 270.082 361.933 1.00 11.32 ? 193 PHE C CZ  1 
ATOM   5351 N N   . TYR C 3 194 ? 184.437 263.110 363.230 1.00 5.09  ? 194 TYR C N   1 
ATOM   5352 C CA  . TYR C 3 194 ? 184.047 261.713 363.097 1.00 8.35  ? 194 TYR C CA  1 
ATOM   5353 C C   . TYR C 3 194 ? 183.100 261.575 361.912 1.00 6.38  ? 194 TYR C C   1 
ATOM   5354 O O   . TYR C 3 194 ? 182.083 262.272 361.844 1.00 13.66 ? 194 TYR C O   1 
ATOM   5355 C CB  . TYR C 3 194 ? 183.372 261.215 364.370 1.00 7.80  ? 194 TYR C CB  1 
ATOM   5356 C CG  . TYR C 3 194 ? 184.301 261.060 365.547 1.00 9.18  ? 194 TYR C CG  1 
ATOM   5357 C CD1 . TYR C 3 194 ? 185.090 259.927 365.686 1.00 8.64  ? 194 TYR C CD1 1 
ATOM   5358 C CD2 . TYR C 3 194 ? 184.380 262.040 366.525 1.00 5.31  ? 194 TYR C CD2 1 
ATOM   5359 C CE1 . TYR C 3 194 ? 185.934 259.777 366.760 1.00 8.44  ? 194 TYR C CE1 1 
ATOM   5360 C CE2 . TYR C 3 194 ? 185.222 261.900 367.604 1.00 6.92  ? 194 TYR C CE2 1 
ATOM   5361 C CZ  . TYR C 3 194 ? 185.997 260.765 367.716 1.00 10.75 ? 194 TYR C CZ  1 
ATOM   5362 O OH  . TYR C 3 194 ? 186.838 260.620 368.789 1.00 18.97 ? 194 TYR C OH  1 
ATOM   5363 N N   . GLN C 3 195 ? 183.430 260.684 360.976 1.00 7.59  ? 195 GLN C N   1 
ATOM   5364 C CA  . GLN C 3 195 ? 182.507 260.413 359.880 1.00 10.03 ? 195 GLN C CA  1 
ATOM   5365 C C   . GLN C 3 195 ? 181.390 259.483 360.338 1.00 8.55  ? 195 GLN C C   1 
ATOM   5366 O O   . GLN C 3 195 ? 180.208 259.789 360.149 1.00 15.75 ? 195 GLN C O   1 
ATOM   5367 C CB  . GLN C 3 195 ? 183.250 259.827 358.679 1.00 8.70  ? 195 GLN C CB  1 
ATOM   5368 C CG  . GLN C 3 195 ? 182.365 259.522 357.466 1.00 10.42 ? 195 GLN C CG  1 
ATOM   5369 C CD  . GLN C 3 195 ? 181.798 260.764 356.791 1.00 9.27  ? 195 GLN C CD  1 
ATOM   5370 O OE1 . GLN C 3 195 ? 181.703 261.830 357.394 1.00 21.82 ? 195 GLN C OE1 1 
ATOM   5371 N NE2 . GLN C 3 195 ? 181.429 260.626 355.524 1.00 5.55  ? 195 GLN C NE2 1 
ATOM   5372 N N   . THR C 3 196 ? 181.736 258.341 360.947 1.00 12.12 ? 196 THR C N   1 
ATOM   5373 C CA  . THR C 3 196 ? 180.720 257.502 361.560 1.00 7.41  ? 196 THR C CA  1 
ATOM   5374 C C   . THR C 3 196 ? 180.964 257.453 363.059 1.00 10.96 ? 196 THR C C   1 
ATOM   5375 O O   . THR C 3 196 ? 180.260 258.127 363.820 1.00 22.64 ? 196 THR C O   1 
ATOM   5376 C CB  . THR C 3 196 ? 180.734 256.111 360.907 1.00 11.75 ? 196 THR C CB  1 
ATOM   5377 O OG1 . THR C 3 196 ? 182.035 255.526 361.050 1.00 13.04 ? 196 THR C OG1 1 
ATOM   5378 C CG2 . THR C 3 196 ? 180.372 256.189 359.426 1.00 9.90  ? 196 THR C CG2 1 
ATOM   5379 N N   . ARG C 3 197 ? 181.988 256.736 363.520 1.00 10.50 ? 197 ARG C N   1 
ATOM   5380 C CA  . ARG C 3 197 ? 182.484 256.768 364.892 1.00 7.78  ? 197 ARG C CA  1 
ATOM   5381 C C   . ARG C 3 197 ? 183.560 255.700 364.999 1.00 10.66 ? 197 ARG C C   1 
ATOM   5382 O O   . ARG C 3 197 ? 183.628 254.785 364.176 1.00 11.67 ? 197 ARG C O   1 
ATOM   5383 C CB  . ARG C 3 197 ? 181.392 256.549 365.958 1.00 9.03  ? 197 ARG C CB  1 
ATOM   5384 C CG  . ARG C 3 197 ? 180.946 255.110 366.211 1.00 6.75  ? 197 ARG C CG  1 
ATOM   5385 C CD  . ARG C 3 197 ? 180.062 255.070 367.454 1.00 8.46  ? 197 ARG C CD  1 
ATOM   5386 N NE  . ARG C 3 197 ? 179.447 253.771 367.703 1.00 11.31 ? 197 ARG C NE  1 
ATOM   5387 C CZ  . ARG C 3 197 ? 179.965 252.820 368.471 1.00 8.70  ? 197 ARG C CZ  1 
ATOM   5388 N NH1 . ARG C 3 197 ? 181.144 252.961 369.053 1.00 18.20 ? 197 ARG C NH1 1 
ATOM   5389 N NH2 . ARG C 3 197 ? 179.280 251.697 368.659 1.00 9.16  ? 197 ARG C NH2 1 
ATOM   5390 N N   . VAL C 3 198 ? 184.385 255.810 366.027 1.00 9.54  ? 198 VAL C N   1 
ATOM   5391 C CA  . VAL C 3 198 ? 185.329 254.745 366.337 1.00 10.70 ? 198 VAL C CA  1 
ATOM   5392 C C   . VAL C 3 198 ? 184.578 253.627 367.044 1.00 5.19  ? 198 VAL C C   1 
ATOM   5393 O O   . VAL C 3 198 ? 183.855 253.867 368.017 1.00 17.13 ? 198 VAL C O   1 
ATOM   5394 C CB  . VAL C 3 198 ? 186.492 255.275 367.190 1.00 10.92 ? 198 VAL C CB  1 
ATOM   5395 C CG1 . VAL C 3 198 ? 187.297 254.124 367.772 1.00 12.98 ? 198 VAL C CG1 1 
ATOM   5396 C CG2 . VAL C 3 198 ? 187.379 256.180 366.356 1.00 10.96 ? 198 VAL C CG2 1 
ATOM   5397 N N   . VAL C 3 199 ? 184.727 252.405 366.544 1.00 7.30  ? 199 VAL C N   1 
ATOM   5398 C CA  . VAL C 3 199 ? 184.065 251.237 367.107 1.00 7.27  ? 199 VAL C CA  1 
ATOM   5399 C C   . VAL C 3 199 ? 185.127 250.232 367.520 1.00 8.58  ? 199 VAL C C   1 
ATOM   5400 O O   . VAL C 3 199 ? 186.053 249.942 366.755 1.00 10.90 ? 199 VAL C O   1 
ATOM   5401 C CB  . VAL C 3 199 ? 183.073 250.597 366.111 1.00 6.23  ? 199 VAL C CB  1 
ATOM   5402 C CG1 . VAL C 3 199 ? 182.370 249.409 366.757 1.00 9.46  ? 199 VAL C CG1 1 
ATOM   5403 C CG2 . VAL C 3 199 ? 182.066 251.628 365.622 1.00 5.46  ? 199 VAL C CG2 1 
ATOM   5404 N N   . VAL C 3 200 ? 184.992 249.706 368.731 1.00 7.12  ? 200 VAL C N   1 
ATOM   5405 C CA  . VAL C 3 200 ? 185.892 248.672 369.230 1.00 12.33 ? 200 VAL C CA  1 
ATOM   5406 C C   . VAL C 3 200 ? 185.053 247.514 369.754 1.00 10.93 ? 200 VAL C C   1 
ATOM   5407 O O   . VAL C 3 200 ? 183.911 247.724 370.184 1.00 15.53 ? 200 VAL C O   1 
ATOM   5408 C CB  . VAL C 3 200 ? 186.830 249.214 370.322 1.00 10.68 ? 200 VAL C CB  1 
ATOM   5409 C CG1 . VAL C 3 200 ? 187.765 250.261 369.744 1.00 6.67  ? 200 VAL C CG1 1 
ATOM   5410 C CG2 . VAL C 3 200 ? 186.030 249.788 371.490 1.00 10.40 ? 200 VAL C CG2 1 
ATOM   5411 N N   . PRO C 3 201 ? 185.559 246.291 369.728 1.00 13.30 ? 201 PRO C N   1 
ATOM   5412 C CA  . PRO C 3 201 ? 184.882 245.187 370.407 1.00 10.52 ? 201 PRO C CA  1 
ATOM   5413 C C   . PRO C 3 201 ? 185.217 245.219 371.894 1.00 7.23  ? 201 PRO C C   1 
ATOM   5414 O O   . PRO C 3 201 ? 185.882 246.128 372.385 1.00 12.73 ? 201 PRO C O   1 
ATOM   5415 C CB  . PRO C 3 201 ? 185.453 243.955 369.708 1.00 9.93  ? 201 PRO C CB  1 
ATOM   5416 C CG  . PRO C 3 201 ? 186.835 244.360 369.345 1.00 8.28  ? 201 PRO C CG  1 
ATOM   5417 C CD  . PRO C 3 201 ? 186.785 245.840 369.045 1.00 3.64  ? 201 PRO C CD  1 
ATOM   5418 N N   . LEU C 3 202 ? 184.742 244.206 372.612 1.00 4.14  ? 202 LEU C N   1 
ATOM   5419 C CA  . LEU C 3 202 ? 185.048 244.105 374.029 1.00 10.54 ? 202 LEU C CA  1 
ATOM   5420 C C   . LEU C 3 202 ? 186.530 243.789 374.230 1.00 7.31  ? 202 LEU C C   1 
ATOM   5421 O O   . LEU C 3 202 ? 187.232 243.344 373.318 1.00 11.59 ? 202 LEU C O   1 
ATOM   5422 C CB  . LEU C 3 202 ? 184.183 243.033 374.690 1.00 11.17 ? 202 LEU C CB  1 
ATOM   5423 C CG  . LEU C 3 202 ? 182.672 243.275 374.676 1.00 15.99 ? 202 LEU C CG  1 
ATOM   5424 C CD1 . LEU C 3 202 ? 181.943 242.131 375.369 1.00 10.52 ? 202 LEU C CD1 1 
ATOM   5425 C CD2 . LEU C 3 202 ? 182.332 244.607 375.327 1.00 7.03  ? 202 LEU C CD2 1 
ATOM   5426 N N   . SER C 3 203 ? 187.003 244.026 375.451 1.00 9.62  ? 203 SER C N   1 
ATOM   5427 C CA  . SER C 3 203 ? 188.390 243.742 375.818 1.00 11.90 ? 203 SER C CA  1 
ATOM   5428 C C   . SER C 3 203 ? 189.362 244.512 374.927 1.00 12.13 ? 203 SER C C   1 
ATOM   5429 O O   . SER C 3 203 ? 190.431 244.020 374.564 1.00 11.32 ? 203 SER C O   1 
ATOM   5430 C CB  . SER C 3 203 ? 188.670 242.240 375.752 1.00 9.27  ? 203 SER C CB  1 
ATOM   5431 O OG  . SER C 3 203 ? 187.765 241.517 376.563 1.00 19.07 ? 203 SER C OG  1 
ATOM   5432 N N   . THR C 3 204 ? 188.983 245.736 374.566 1.00 11.08 ? 204 THR C N   1 
ATOM   5433 C CA  . THR C 3 204 ? 189.788 246.586 373.705 1.00 10.29 ? 204 THR C CA  1 
ATOM   5434 C C   . THR C 3 204 ? 189.841 247.989 374.296 1.00 9.84  ? 204 THR C C   1 
ATOM   5435 O O   . THR C 3 204 ? 188.843 248.455 374.859 1.00 22.35 ? 204 THR C O   1 
ATOM   5436 C CB  . THR C 3 204 ? 189.197 246.644 372.284 1.00 16.03 ? 204 THR C CB  1 
ATOM   5437 O OG1 . THR C 3 204 ? 188.936 245.316 371.816 1.00 15.28 ? 204 THR C OG1 1 
ATOM   5438 C CG2 . THR C 3 204 ? 190.148 247.340 371.323 1.00 13.44 ? 204 THR C CG2 1 
ATOM   5439 N N   . PRO C 3 205 ? 190.971 248.688 374.190 1.00 10.83 ? 205 PRO C N   1 
ATOM   5440 C CA  . PRO C 3 205 ? 191.002 250.079 374.657 1.00 14.84 ? 205 PRO C CA  1 
ATOM   5441 C C   . PRO C 3 205 ? 189.958 250.914 373.931 1.00 8.34  ? 205 PRO C C   1 
ATOM   5442 O O   . PRO C 3 205 ? 189.862 250.889 372.703 1.00 5.24  ? 205 PRO C O   1 
ATOM   5443 C CB  . PRO C 3 205 ? 192.429 250.536 374.330 1.00 12.42 ? 205 PRO C CB  1 
ATOM   5444 C CG  . PRO C 3 205 ? 193.221 249.281 374.242 1.00 9.59  ? 205 PRO C CG  1 
ATOM   5445 C CD  . PRO C 3 205 ? 192.287 248.250 373.692 1.00 12.73 ? 205 PRO C CD  1 
ATOM   5446 N N   . ARG C 3 206 ? 189.168 251.652 374.706 1.00 13.30 ? 206 ARG C N   1 
ATOM   5447 C CA  . ARG C 3 206 ? 188.121 252.502 374.158 1.00 16.92 ? 206 ARG C CA  1 
ATOM   5448 C C   . ARG C 3 206 ? 188.599 253.919 373.874 1.00 13.55 ? 206 ARG C C   1 
ATOM   5449 O O   . ARG C 3 206 ? 187.840 254.711 373.307 1.00 17.88 ? 206 ARG C O   1 
ATOM   5450 C CB  . ARG C 3 206 ? 186.922 252.536 375.114 1.00 14.40 ? 206 ARG C CB  1 
ATOM   5451 C CG  . ARG C 3 206 ? 186.270 251.172 375.298 1.00 15.41 ? 206 ARG C CG  1 
ATOM   5452 C CD  . ARG C 3 206 ? 185.110 251.200 376.281 1.00 17.92 ? 206 ARG C CD  1 
ATOM   5453 N NE  . ARG C 3 206 ? 183.993 252.005 375.797 1.00 20.86 ? 206 ARG C NE  1 
ATOM   5454 C CZ  . ARG C 3 206 ? 183.531 253.105 376.379 1.00 22.16 ? 206 ARG C CZ  1 
ATOM   5455 N NH1 . ARG C 3 206 ? 184.053 253.573 377.503 1.00 22.95 ? 206 ARG C NH1 1 
ATOM   5456 N NH2 . ARG C 3 206 ? 182.510 253.751 375.824 1.00 21.29 ? 206 ARG C NH2 1 
ATOM   5457 N N   . LYS C 3 207 ? 189.827 254.255 374.259 1.00 15.49 ? 207 LYS C N   1 
ATOM   5458 C CA  . LYS C 3 207 ? 190.448 255.526 373.917 1.00 12.88 ? 207 LYS C CA  1 
ATOM   5459 C C   . LYS C 3 207 ? 191.793 255.235 373.273 1.00 11.31 ? 207 LYS C C   1 
ATOM   5460 O O   . LYS C 3 207 ? 192.560 254.411 373.779 1.00 23.21 ? 207 LYS C O   1 
ATOM   5461 C CB  . LYS C 3 207 ? 190.630 256.415 375.151 1.00 9.26  ? 207 LYS C CB  1 
ATOM   5462 C CG  . LYS C 3 207 ? 189.343 256.701 375.896 1.00 21.12 ? 207 LYS C CG  1 
ATOM   5463 C CD  . LYS C 3 207 ? 189.604 257.447 377.190 1.00 17.24 ? 207 LYS C CD  1 
ATOM   5464 C CE  . LYS C 3 207 ? 188.336 257.580 378.015 1.00 19.57 ? 207 LYS C CE  1 
ATOM   5465 N NZ  . LYS C 3 207 ? 188.572 258.286 379.304 1.00 24.37 ? 207 LYS C NZ  1 
ATOM   5466 N N   . MET C 3 208 ? 192.071 255.896 372.155 1.00 6.94  ? 208 MET C N   1 
ATOM   5467 C CA  . MET C 3 208 ? 193.339 255.732 371.461 1.00 8.04  ? 208 MET C CA  1 
ATOM   5468 C C   . MET C 3 208 ? 193.808 257.100 370.989 1.00 13.31 ? 208 MET C C   1 
ATOM   5469 O O   . MET C 3 208 ? 193.108 258.102 371.136 1.00 19.25 ? 208 MET C O   1 
ATOM   5470 C CB  . MET C 3 208 ? 193.211 254.748 370.294 1.00 12.51 ? 208 MET C CB  1 
ATOM   5471 C CG  . MET C 3 208 ? 192.217 255.163 369.227 1.00 13.22 ? 208 MET C CG  1 
ATOM   5472 S SD  . MET C 3 208 ? 190.528 255.359 369.822 1.00 30.53 ? 208 MET C SD  1 
ATOM   5473 C CE  . MET C 3 208 ? 190.082 253.662 370.180 1.00 10.99 ? 208 MET C CE  1 
ATOM   5474 N N   . ASP C 3 209 ? 195.007 257.142 370.423 1.00 10.94 ? 209 ASP C N   1 
ATOM   5475 C CA  . ASP C 3 209 ? 195.626 258.388 370.001 1.00 9.29  ? 209 ASP C CA  1 
ATOM   5476 C C   . ASP C 3 209 ? 195.859 258.378 368.499 1.00 8.81  ? 209 ASP C C   1 
ATOM   5477 O O   . ASP C 3 209 ? 196.138 257.333 367.906 1.00 14.60 ? 209 ASP C O   1 
ATOM   5478 C CB  . ASP C 3 209 ? 196.952 258.620 370.729 1.00 15.70 ? 209 ASP C CB  1 
ATOM   5479 C CG  . ASP C 3 209 ? 196.765 258.879 372.209 1.00 17.28 ? 209 ASP C CG  1 
ATOM   5480 O OD1 . ASP C 3 209 ? 195.793 259.572 372.576 1.00 22.13 ? 209 ASP C OD1 1 
ATOM   5481 O OD2 . ASP C 3 209 ? 197.587 258.387 373.005 1.00 19.31 ? 209 ASP C OD2 1 
ATOM   5482 N N   . ILE C 3 210 ? 195.720 259.547 367.893 1.00 10.13 ? 210 ILE C N   1 
ATOM   5483 C CA  . ILE C 3 210 ? 196.167 259.790 366.533 1.00 10.17 ? 210 ILE C CA  1 
ATOM   5484 C C   . ILE C 3 210 ? 197.285 260.817 366.595 1.00 4.98  ? 210 ILE C C   1 
ATOM   5485 O O   . ILE C 3 210 ? 197.362 261.640 367.518 1.00 12.71 ? 210 ILE C O   1 
ATOM   5486 C CB  . ILE C 3 210 ? 195.031 260.264 365.600 1.00 13.63 ? 210 ILE C CB  1 
ATOM   5487 C CG1 . ILE C 3 210 ? 194.302 261.467 366.198 1.00 9.36  ? 210 ILE C CG1 1 
ATOM   5488 C CG2 . ILE C 3 210 ? 194.060 259.121 365.324 1.00 9.85  ? 210 ILE C CG2 1 
ATOM   5489 C CD1 . ILE C 3 210 ? 193.457 262.228 365.200 1.00 16.57 ? 210 ILE C CD1 1 
ATOM   5490 N N   . LEU C 3 211 ? 198.166 260.745 365.605 1.00 8.97  ? 211 LEU C N   1 
ATOM   5491 C CA  . LEU C 3 211 ? 199.297 261.648 365.468 1.00 4.06  ? 211 LEU C CA  1 
ATOM   5492 C C   . LEU C 3 211 ? 199.176 262.397 364.151 1.00 8.55  ? 211 LEU C C   1 
ATOM   5493 O O   . LEU C 3 211 ? 198.762 261.825 363.140 1.00 11.77 ? 211 LEU C O   1 
ATOM   5494 C CB  . LEU C 3 211 ? 200.624 260.885 365.512 1.00 10.24 ? 211 LEU C CB  1 
ATOM   5495 C CG  . LEU C 3 211 ? 200.809 259.923 366.687 1.00 12.66 ? 211 LEU C CG  1 
ATOM   5496 C CD1 . LEU C 3 211 ? 202.062 259.085 366.497 1.00 10.67 ? 211 LEU C CD1 1 
ATOM   5497 C CD2 . LEU C 3 211 ? 200.860 260.687 367.998 1.00 11.09 ? 211 LEU C CD2 1 
ATOM   5498 N N   . GLY C 3 212 ? 199.527 263.675 364.167 1.00 7.83  ? 212 GLY C N   1 
ATOM   5499 C CA  . GLY C 3 212 ? 199.512 264.511 362.976 1.00 8.60  ? 212 GLY C CA  1 
ATOM   5500 C C   . GLY C 3 212 ? 200.926 264.806 362.507 1.00 3.32  ? 212 GLY C C   1 
ATOM   5501 O O   . GLY C 3 212 ? 201.829 265.006 363.322 1.00 13.74 ? 212 GLY C O   1 
ATOM   5502 N N   . PHE C 3 213 ? 201.103 264.830 361.192 1.00 1.58  ? 213 PHE C N   1 
ATOM   5503 C CA  . PHE C 3 213 ? 202.357 265.185 360.550 1.00 6.10  ? 213 PHE C CA  1 
ATOM   5504 C C   . PHE C 3 213 ? 202.066 266.167 359.426 1.00 10.95 ? 213 PHE C C   1 
ATOM   5505 O O   . PHE C 3 213 ? 201.035 266.073 358.758 1.00 1.84  ? 213 PHE C O   1 
ATOM   5506 C CB  . PHE C 3 213 ? 203.076 263.952 359.982 1.00 8.30  ? 213 PHE C CB  1 
ATOM   5507 C CG  . PHE C 3 213 ? 203.445 262.931 361.017 1.00 9.17  ? 213 PHE C CG  1 
ATOM   5508 C CD1 . PHE C 3 213 ? 202.516 262.003 361.453 1.00 7.13  ? 213 PHE C CD1 1 
ATOM   5509 C CD2 . PHE C 3 213 ? 204.723 262.893 361.547 1.00 6.62  ? 213 PHE C CD2 1 
ATOM   5510 C CE1 . PHE C 3 213 ? 202.849 261.062 362.404 1.00 9.51  ? 213 PHE C CE1 1 
ATOM   5511 C CE2 . PHE C 3 213 ? 205.064 261.949 362.500 1.00 10.47 ? 213 PHE C CE2 1 
ATOM   5512 C CZ  . PHE C 3 213 ? 204.124 261.033 362.928 1.00 9.79  ? 213 PHE C CZ  1 
ATOM   5513 N N   . VAL C 3 214 ? 202.984 267.104 359.215 1.00 8.40  ? 214 VAL C N   1 
ATOM   5514 C CA  . VAL C 3 214 ? 202.864 268.086 358.147 1.00 3.82  ? 214 VAL C CA  1 
ATOM   5515 C C   . VAL C 3 214 ? 204.171 268.132 357.370 1.00 5.41  ? 214 VAL C C   1 
ATOM   5516 O O   . VAL C 3 214 ? 205.255 268.008 357.948 1.00 13.54 ? 214 VAL C O   1 
ATOM   5517 C CB  . VAL C 3 214 ? 202.504 269.487 358.685 1.00 8.90  ? 214 VAL C CB  1 
ATOM   5518 C CG1 . VAL C 3 214 ? 203.643 270.056 359.522 1.00 6.61  ? 214 VAL C CG1 1 
ATOM   5519 C CG2 . VAL C 3 214 ? 202.150 270.419 357.534 1.00 9.20  ? 214 VAL C CG2 1 
ATOM   5520 N N   . SER C 3 215 ? 204.063 268.305 356.058 1.00 7.01  ? 215 SER C N   1 
ATOM   5521 C CA  . SER C 3 215 ? 205.231 268.529 355.218 1.00 11.14 ? 215 SER C CA  1 
ATOM   5522 C C   . SER C 3 215 ? 204.835 269.412 354.044 1.00 6.31  ? 215 SER C C   1 
ATOM   5523 O O   . SER C 3 215 ? 203.656 269.668 353.799 1.00 12.81 ? 215 SER C O   1 
ATOM   5524 C CB  . SER C 3 215 ? 205.838 267.213 354.721 1.00 3.65  ? 215 SER C CB  1 
ATOM   5525 O OG  . SER C 3 215 ? 204.880 266.430 354.037 1.00 17.97 ? 215 SER C OG  1 
ATOM   5526 N N   . ALA C 3 216 ? 205.844 269.881 353.324 1.00 9.25  ? 216 ALA C N   1 
ATOM   5527 C CA  . ALA C 3 216 ? 205.639 270.642 352.105 1.00 11.43 ? 216 ALA C CA  1 
ATOM   5528 C C   . ALA C 3 216 ? 205.682 269.717 350.896 1.00 9.20  ? 216 ALA C C   1 
ATOM   5529 O O   . ALA C 3 216 ? 206.434 268.741 350.864 1.00 16.18 ? 216 ALA C O   1 
ATOM   5530 C CB  . ALA C 3 216 ? 206.700 271.732 351.966 1.00 6.34  ? 216 ALA C CB  1 
ATOM   5531 N N   . CYS C 3 217 ? 204.859 270.030 349.899 1.00 15.39 ? 217 CYS C N   1 
ATOM   5532 C CA  . CYS C 3 217 ? 204.856 269.287 348.649 1.00 14.61 ? 217 CYS C CA  1 
ATOM   5533 C C   . CYS C 3 217 ? 206.001 269.764 347.757 1.00 7.26  ? 217 CYS C C   1 
ATOM   5534 O O   . CYS C 3 217 ? 206.762 270.668 348.107 1.00 17.95 ? 217 CYS C O   1 
ATOM   5535 C CB  . CYS C 3 217 ? 203.510 269.436 347.946 1.00 14.08 ? 217 CYS C CB  1 
ATOM   5536 S SG  . CYS C 3 217 ? 202.094 268.894 348.927 1.00 26.22 ? 217 CYS C SG  1 
ATOM   5537 N N   . ASN C 3 218 ? 206.127 269.149 346.579 1.00 14.90 ? 218 ASN C N   1 
ATOM   5538 C CA  . ASN C 3 218 ? 207.209 269.496 345.665 1.00 7.39  ? 218 ASN C CA  1 
ATOM   5539 C C   . ASN C 3 218 ? 207.013 270.852 344.994 1.00 12.02 ? 218 ASN C C   1 
ATOM   5540 O O   . ASN C 3 218 ? 207.963 271.369 344.399 1.00 21.32 ? 218 ASN C O   1 
ATOM   5541 C CB  . ASN C 3 218 ? 207.374 268.407 344.597 1.00 11.18 ? 218 ASN C CB  1 
ATOM   5542 C CG  . ASN C 3 218 ? 206.101 268.152 343.804 1.00 21.46 ? 218 ASN C CG  1 
ATOM   5543 O OD1 . ASN C 3 218 ? 205.211 268.999 343.735 1.00 22.79 ? 218 ASN C OD1 1 
ATOM   5544 N ND2 . ASN C 3 218 ? 206.015 266.975 343.195 1.00 24.87 ? 218 ASN C ND2 1 
ATOM   5545 N N   . ASP C 3 219 ? 205.823 271.439 345.074 1.00 12.94 ? 219 ASP C N   1 
ATOM   5546 C CA  . ASP C 3 219 ? 205.574 272.762 344.516 1.00 15.26 ? 219 ASP C CA  1 
ATOM   5547 C C   . ASP C 3 219 ? 205.853 273.883 345.510 1.00 9.33  ? 219 ASP C C   1 
ATOM   5548 O O   . ASP C 3 219 ? 205.625 275.051 345.186 1.00 19.04 ? 219 ASP C O   1 
ATOM   5549 C CB  . ASP C 3 219 ? 204.126 272.861 344.023 1.00 9.47  ? 219 ASP C CB  1 
ATOM   5550 C CG  . ASP C 3 219 ? 203.113 272.783 345.152 1.00 12.81 ? 219 ASP C CG  1 
ATOM   5551 O OD1 . ASP C 3 219 ? 203.505 272.491 346.300 1.00 21.41 ? 219 ASP C OD1 1 
ATOM   5552 O OD2 . ASP C 3 219 ? 201.917 273.016 344.890 1.00 20.24 ? 219 ASP C OD2 1 
ATOM   5553 N N   . PHE C 3 220 ? 206.336 273.556 346.704 1.00 11.20 ? 220 PHE C N   1 
ATOM   5554 C CA  . PHE C 3 220 ? 206.525 274.542 347.756 1.00 8.70  ? 220 PHE C CA  1 
ATOM   5555 C C   . PHE C 3 220 ? 207.800 275.342 347.528 1.00 9.72  ? 220 PHE C C   1 
ATOM   5556 O O   . PHE C 3 220 ? 208.819 274.803 347.087 1.00 15.91 ? 220 PHE C O   1 
ATOM   5557 C CB  . PHE C 3 220 ? 206.581 273.843 349.113 1.00 14.67 ? 220 PHE C CB  1 
ATOM   5558 C CG  . PHE C 3 220 ? 206.169 274.707 350.266 1.00 9.23  ? 220 PHE C CG  1 
ATOM   5559 C CD1 . PHE C 3 220 ? 207.074 275.560 350.869 1.00 8.00  ? 220 PHE C CD1 1 
ATOM   5560 C CD2 . PHE C 3 220 ? 204.880 274.641 350.768 1.00 11.44 ? 220 PHE C CD2 1 
ATOM   5561 C CE1 . PHE C 3 220 ? 206.697 276.345 351.940 1.00 12.45 ? 220 PHE C CE1 1 
ATOM   5562 C CE2 . PHE C 3 220 ? 204.499 275.423 351.839 1.00 12.28 ? 220 PHE C CE2 1 
ATOM   5563 C CZ  . PHE C 3 220 ? 205.411 276.275 352.427 1.00 9.92  ? 220 PHE C CZ  1 
ATOM   5564 N N   . SER C 3 221 ? 207.737 276.638 347.826 1.00 7.78  ? 221 SER C N   1 
ATOM   5565 C CA  . SER C 3 221 ? 208.898 277.510 347.752 1.00 8.38  ? 221 SER C CA  1 
ATOM   5566 C C   . SER C 3 221 ? 208.747 278.641 348.759 1.00 7.29  ? 221 SER C C   1 
ATOM   5567 O O   . SER C 3 221 ? 207.643 278.940 349.226 1.00 12.81 ? 221 SER C O   1 
ATOM   5568 C CB  . SER C 3 221 ? 209.091 278.085 346.345 1.00 12.82 ? 221 SER C CB  1 
ATOM   5569 O OG  . SER C 3 221 ? 208.039 278.969 346.012 1.00 20.04 ? 221 SER C OG  1 
ATOM   5570 N N   . VAL C 3 222 ? 209.880 279.256 349.100 1.00 4.92  ? 222 VAL C N   1 
ATOM   5571 C CA  . VAL C 3 222 ? 209.937 280.352 350.055 1.00 6.69  ? 222 VAL C CA  1 
ATOM   5572 C C   . VAL C 3 222 ? 210.810 281.461 349.480 1.00 0.06  ? 222 VAL C C   1 
ATOM   5573 O O   . VAL C 3 222 ? 211.597 281.252 348.558 1.00 10.88 ? 222 VAL C O   1 
ATOM   5574 C CB  . VAL C 3 222 ? 210.465 279.901 351.434 1.00 3.92  ? 222 VAL C CB  1 
ATOM   5575 C CG1 . VAL C 3 222 ? 209.489 278.935 352.076 1.00 4.81  ? 222 VAL C CG1 1 
ATOM   5576 C CG2 . VAL C 3 222 ? 211.846 279.273 351.305 1.00 6.15  ? 222 VAL C CG2 1 
ATOM   5577 N N   . ARG C 3 223 ? 210.651 282.656 350.041 1.00 8.67  ? 223 ARG C N   1 
ATOM   5578 C CA  . ARG C 3 223 ? 211.381 283.825 349.569 1.00 8.82  ? 223 ARG C CA  1 
ATOM   5579 C C   . ARG C 3 223 ? 211.634 284.774 350.728 1.00 2.85  ? 223 ARG C C   1 
ATOM   5580 O O   . ARG C 3 223 ? 210.949 284.740 351.757 1.00 5.30  ? 223 ARG C O   1 
ATOM   5581 C CB  . ARG C 3 223 ? 210.629 284.586 348.472 1.00 3.13  ? 223 ARG C CB  1 
ATOM   5582 C CG  . ARG C 3 223 ? 210.042 283.751 347.364 1.00 7.62  ? 223 ARG C CG  1 
ATOM   5583 C CD  . ARG C 3 223 ? 209.569 284.650 346.236 1.00 9.53  ? 223 ARG C CD  1 
ATOM   5584 N NE  . ARG C 3 223 ? 208.624 285.661 346.695 1.00 7.77  ? 223 ARG C NE  1 
ATOM   5585 C CZ  . ARG C 3 223 ? 208.024 286.541 345.906 1.00 7.58  ? 223 ARG C CZ  1 
ATOM   5586 N NH1 . ARG C 3 223 ? 208.233 286.556 344.600 1.00 7.27  ? 223 ARG C NH1 1 
ATOM   5587 N NH2 . ARG C 3 223 ? 207.193 287.429 346.440 1.00 3.05  ? 223 ARG C NH2 1 
ATOM   5588 N N   . LEU C 3 224 ? 212.587 285.682 350.493 1.00 9.46  ? 224 LEU C N   1 
ATOM   5589 C CA  . LEU C 3 224 ? 212.922 286.787 351.389 1.00 7.79  ? 224 LEU C CA  1 
ATOM   5590 C C   . LEU C 3 224 ? 213.407 286.264 352.746 1.00 6.04  ? 224 LEU C C   1 
ATOM   5591 O O   . LEU C 3 224 ? 212.738 286.364 353.775 1.00 12.78 ? 224 LEU C O   1 
ATOM   5592 C CB  . LEU C 3 224 ? 211.727 287.736 351.535 1.00 8.83  ? 224 LEU C CB  1 
ATOM   5593 C CG  . LEU C 3 224 ? 211.922 289.124 352.165 1.00 12.75 ? 224 LEU C CG  1 
ATOM   5594 C CD1 . LEU C 3 224 ? 213.371 289.438 352.524 1.00 9.12  ? 224 LEU C CD1 1 
ATOM   5595 C CD2 . LEU C 3 224 ? 211.362 290.196 351.236 1.00 8.15  ? 224 LEU C CD2 1 
ATOM   5596 N N   . LEU C 3 225 ? 214.591 285.657 352.690 1.00 6.73  ? 225 LEU C N   1 
ATOM   5597 C CA  . LEU C 3 225 ? 215.300 285.237 353.891 1.00 5.39  ? 225 LEU C CA  1 
ATOM   5598 C C   . LEU C 3 225 ? 215.226 286.306 354.974 1.00 0.12  ? 225 LEU C C   1 
ATOM   5599 O O   . LEU C 3 225 ? 215.402 287.497 354.712 1.00 14.78 ? 225 LEU C O   1 
ATOM   5600 C CB  . LEU C 3 225 ? 216.761 284.943 353.553 1.00 5.12  ? 225 LEU C CB  1 
ATOM   5601 C CG  . LEU C 3 225 ? 217.646 284.444 354.696 1.00 10.06 ? 225 LEU C CG  1 
ATOM   5602 C CD1 . LEU C 3 225 ? 217.294 283.011 355.065 1.00 5.90  ? 225 LEU C CD1 1 
ATOM   5603 C CD2 . LEU C 3 225 ? 219.114 284.565 354.322 1.00 9.78  ? 225 LEU C CD2 1 
ATOM   5604 N N   . ARG C 3 226 ? 214.969 285.864 356.201 1.00 0.01  ? 226 ARG C N   1 
ATOM   5605 C CA  . ARG C 3 226 ? 214.865 286.761 357.340 1.00 1.56  ? 226 ARG C CA  1 
ATOM   5606 C C   . ARG C 3 226 ? 215.261 286.008 358.599 1.00 6.42  ? 226 ARG C C   1 
ATOM   5607 O O   . ARG C 3 226 ? 215.269 284.775 358.632 1.00 9.32  ? 226 ARG C O   1 
ATOM   5608 C CB  . ARG C 3 226 ? 213.448 287.329 357.491 1.00 7.43  ? 226 ARG C CB  1 
ATOM   5609 C CG  . ARG C 3 226 ? 212.372 286.293 357.820 1.00 7.82  ? 226 ARG C CG  1 
ATOM   5610 C CD  . ARG C 3 226 ? 211.120 286.966 358.354 1.00 14.55 ? 226 ARG C CD  1 
ATOM   5611 N NE  . ARG C 3 226 ? 210.060 286.020 358.682 1.00 12.65 ? 226 ARG C NE  1 
ATOM   5612 C CZ  . ARG C 3 226 ? 209.904 285.437 359.863 1.00 6.01  ? 226 ARG C CZ  1 
ATOM   5613 N NH1 . ARG C 3 226 ? 210.747 285.650 360.859 1.00 11.41 ? 226 ARG C NH1 1 
ATOM   5614 N NH2 . ARG C 3 226 ? 208.874 284.617 360.049 1.00 10.83 ? 226 ARG C NH2 1 
ATOM   5615 N N   . ASP C 3 227 ? 215.587 286.768 359.639 1.00 5.73  ? 227 ASP C N   1 
ATOM   5616 C CA  . ASP C 3 227 ? 215.870 286.173 360.936 1.00 10.04 ? 227 ASP C CA  1 
ATOM   5617 C C   . ASP C 3 227 ? 214.584 285.678 361.588 1.00 13.14 ? 227 ASP C C   1 
ATOM   5618 O O   . ASP C 3 227 ? 213.504 286.246 361.404 1.00 13.90 ? 227 ASP C O   1 
ATOM   5619 C CB  . ASP C 3 227 ? 216.578 287.179 361.844 1.00 6.30  ? 227 ASP C CB  1 
ATOM   5620 C CG  . ASP C 3 227 ? 218.057 287.304 361.526 1.00 16.15 ? 227 ASP C CG  1 
ATOM   5621 O OD1 . ASP C 3 227 ? 218.764 286.277 361.576 1.00 21.38 ? 227 ASP C OD1 1 
ATOM   5622 O OD2 . ASP C 3 227 ? 218.511 288.420 361.209 1.00 12.14 ? 227 ASP C OD2 1 
ATOM   5623 N N   . THR C 3 228 ? 214.710 284.598 362.348 1.00 10.16 ? 228 THR C N   1 
ATOM   5624 C CA  . THR C 3 228 ? 213.570 283.969 362.994 1.00 11.03 ? 228 THR C CA  1 
ATOM   5625 C C   . THR C 3 228 ? 213.359 284.538 364.393 1.00 4.44  ? 228 THR C C   1 
ATOM   5626 O O   . THR C 3 228 ? 214.275 285.069 365.023 1.00 17.04 ? 228 THR C O   1 
ATOM   5627 C CB  . THR C 3 228 ? 213.763 282.451 363.075 1.00 8.93  ? 228 THR C CB  1 
ATOM   5628 O OG1 . THR C 3 228 ? 212.616 281.853 363.690 1.00 16.54 ? 228 THR C OG1 1 
ATOM   5629 C CG2 . THR C 3 228 ? 215.014 282.098 363.880 1.00 7.01  ? 228 THR C CG2 1 
ATOM   5630 N N   . THR C 3 229 ? 212.129 284.409 364.878 1.00 8.69  ? 229 THR C N   1 
ATOM   5631 C CA  . THR C 3 229 ? 211.789 284.757 366.250 1.00 11.38 ? 229 THR C CA  1 
ATOM   5632 C C   . THR C 3 229 ? 211.934 283.580 367.207 1.00 8.46  ? 229 THR C C   1 
ATOM   5633 O O   . THR C 3 229 ? 211.650 283.734 368.398 1.00 19.04 ? 229 THR C O   1 
ATOM   5634 C CB  . THR C 3 229 ? 210.354 285.296 366.323 1.00 10.79 ? 229 THR C CB  1 
ATOM   5635 O OG1 . THR C 3 229 ? 209.438 284.301 365.851 1.00 18.95 ? 229 THR C OG1 1 
ATOM   5636 C CG2 . THR C 3 229 ? 210.205 286.560 365.486 1.00 12.14 ? 229 THR C CG2 1 
ATOM   5637 N N   . HIS C 3 230 ? 212.377 282.419 366.724 1.00 12.16 ? 230 HIS C N   1 
ATOM   5638 C CA  . HIS C 3 230 ? 212.405 281.205 367.528 1.00 13.05 ? 230 HIS C CA  1 
ATOM   5639 C C   . HIS C 3 230 ? 213.669 281.058 368.364 1.00 12.66 ? 230 HIS C C   1 
ATOM   5640 O O   . HIS C 3 230 ? 213.720 280.170 369.219 1.00 18.51 ? 230 HIS C O   1 
ATOM   5641 C CB  . HIS C 3 230 ? 212.249 279.976 366.627 1.00 11.76 ? 230 HIS C CB  1 
ATOM   5642 C CG  . HIS C 3 230 ? 210.880 279.832 366.040 1.00 12.85 ? 230 HIS C CG  1 
ATOM   5643 N ND1 . HIS C 3 230 ? 210.546 278.818 365.169 1.00 16.56 ? 230 HIS C ND1 1 
ATOM   5644 C CD2 . HIS C 3 230 ? 209.758 280.572 366.202 1.00 10.92 ? 230 HIS C CD2 1 
ATOM   5645 C CE1 . HIS C 3 230 ? 209.279 278.941 364.818 1.00 14.64 ? 230 HIS C CE1 1 
ATOM   5646 N NE2 . HIS C 3 230 ? 208.778 279.998 365.430 1.00 16.88 ? 230 HIS C NE2 1 
ATOM   5647 N N   . ILE C 3 231 ? 214.681 281.893 368.145 1.00 16.15 ? 231 ILE C N   1 
ATOM   5648 C CA  . ILE C 3 231 ? 215.899 281.876 368.944 1.00 9.59  ? 231 ILE C CA  1 
ATOM   5649 C C   . ILE C 3 231 ? 216.239 283.305 369.332 1.00 13.86 ? 231 ILE C C   1 
ATOM   5650 O O   . ILE C 3 231 ? 216.107 284.229 368.521 1.00 22.84 ? 231 ILE C O   1 
ATOM   5651 C CB  . ILE C 3 231 ? 217.076 281.216 368.192 1.00 14.53 ? 231 ILE C CB  1 
ATOM   5652 C CG1 . ILE C 3 231 ? 218.128 280.706 369.180 1.00 11.44 ? 231 ILE C CG1 1 
ATOM   5653 C CG2 . ILE C 3 231 ? 217.710 282.189 367.206 1.00 14.40 ? 231 ILE C CG2 1 
ATOM   5654 C CD1 . ILE C 3 231 ? 217.713 279.462 369.938 1.00 13.86 ? 231 ILE C CD1 1 
ATOM   5655 N N   . SER C 3 232 ? 216.665 283.486 370.576 1.00 10.59 ? 232 SER C N   1 
ATOM   5656 C CA  . SER C 3 232 ? 217.092 284.783 371.072 1.00 14.70 ? 232 SER C CA  1 
ATOM   5657 C C   . SER C 3 232 ? 218.265 284.579 372.018 1.00 19.14 ? 232 SER C C   1 
ATOM   5658 O O   . SER C 3 232 ? 218.472 283.491 372.558 1.00 25.95 ? 232 SER C O   1 
ATOM   5659 C CB  . SER C 3 232 ? 215.951 285.520 371.785 1.00 17.73 ? 232 SER C CB  1 
ATOM   5660 O OG  . SER C 3 232 ? 215.517 284.805 372.926 1.00 25.77 ? 232 SER C OG  1 
ATOM   5661 N N   . GLN C 3 233 ? 219.042 285.641 372.207 1.00 20.95 ? 233 GLN C N   1 
ATOM   5662 C CA  . GLN C 3 233 ? 220.177 285.628 373.117 1.00 16.03 ? 233 GLN C CA  1 
ATOM   5663 C C   . GLN C 3 233 ? 220.029 286.785 374.090 1.00 26.00 ? 233 GLN C C   1 
ATOM   5664 O O   . GLN C 3 233 ? 219.770 287.920 373.677 1.00 28.02 ? 233 GLN C O   1 
ATOM   5665 C CB  . GLN C 3 233 ? 221.502 285.732 372.355 1.00 18.40 ? 233 GLN C CB  1 
ATOM   5666 C CG  . GLN C 3 233 ? 222.731 285.546 373.225 1.00 22.05 ? 233 GLN C CG  1 
ATOM   5667 C CD  . GLN C 3 233 ? 224.006 285.446 372.417 1.00 19.15 ? 233 GLN C CD  1 
ATOM   5668 O OE1 . GLN C 3 233 ? 224.016 285.713 371.217 1.00 22.12 ? 233 GLN C OE1 1 
ATOM   5669 N NE2 . GLN C 3 233 ? 225.091 285.047 373.071 1.00 24.77 ? 233 GLN C NE2 1 
ATOM   5670 N N   . GLU C 3 234 ? 220.192 286.496 375.375 1.00 32.47 ? 234 GLU C N   1 
ATOM   5671 C CA  . GLU C 3 234 ? 220.051 287.491 376.427 1.00 34.73 ? 234 GLU C CA  1 
ATOM   5672 C C   . GLU C 3 234 ? 221.421 288.010 376.844 1.00 33.63 ? 234 GLU C C   1 
ATOM   5673 O O   . GLU C 3 234 ? 222.391 287.250 376.909 1.00 37.77 ? 234 GLU C O   1 
ATOM   5674 C CB  . GLU C 3 234 ? 219.331 286.895 377.638 1.00 35.52 ? 234 GLU C CB  1 
ATOM   5675 C CG  . GLU C 3 234 ? 217.962 286.311 377.322 1.00 34.50 ? 234 GLU C CG  1 
ATOM   5676 C CD  . GLU C 3 234 ? 217.385 285.533 378.487 1.00 36.92 ? 234 GLU C CD  1 
ATOM   5677 O OE1 . GLU C 3 234 ? 218.126 285.296 379.464 1.00 37.91 ? 234 GLU C OE1 1 
ATOM   5678 O OE2 . GLU C 3 234 ? 216.194 285.161 378.429 1.00 35.72 ? 234 GLU C OE2 1 
ATOM   5679 N N   . ALA C 3 235 ? 221.490 289.306 377.128 1.00 39.61 ? 235 ALA C N   1 
ATOM   5680 C CA  . ALA C 3 235 ? 222.723 289.932 377.597 1.00 38.92 ? 235 ALA C CA  1 
ATOM   5681 C C   . ALA C 3 235 ? 223.876 289.670 376.635 1.00 39.07 ? 235 ALA C C   1 
ATOM   5682 O O   . ALA C 3 235 ? 224.905 289.117 377.023 1.00 40.23 ? 235 ALA C O   1 
ATOM   5683 C CB  . ALA C 3 235 ? 223.074 289.430 378.991 1.00 37.41 ? 235 ALA C CB  1 
HETATM 5684 C C1  . SPH D 4 .   ? 231.909 275.289 361.877 1.00 15.27 ? 401 SPH A C1  1 
HETATM 5685 O O1  . SPH D 4 .   ? 231.284 274.584 360.827 1.00 19.59 ? 401 SPH A O1  1 
HETATM 5686 C C2  . SPH D 4 .   ? 233.237 275.920 361.465 1.00 17.45 ? 401 SPH A C2  1 
HETATM 5687 N N2  . SPH D 4 .   ? 233.195 276.273 360.067 1.00 27.77 ? 401 SPH A N2  1 
HETATM 5688 C C3  . SPH D 4 .   ? 233.526 277.162 362.304 1.00 17.92 ? 401 SPH A C3  1 
HETATM 5689 O O3  . SPH D 4 .   ? 233.555 276.780 363.660 1.00 24.43 ? 401 SPH A O3  1 
HETATM 5690 C C4  . SPH D 4 .   ? 234.845 277.782 361.937 1.00 15.75 ? 401 SPH A C4  1 
HETATM 5691 C C5  . SPH D 4 .   ? 234.964 278.555 360.693 1.00 18.07 ? 401 SPH A C5  1 
HETATM 5692 C C6  . SPH D 4 .   ? 236.280 278.647 359.960 1.00 21.42 ? 401 SPH A C6  1 
HETATM 5693 C C7  . SPH D 4 .   ? 237.384 279.137 360.886 1.00 21.06 ? 401 SPH A C7  1 
HETATM 5694 C C8  . SPH D 4 .   ? 238.705 279.180 360.134 1.00 17.47 ? 401 SPH A C8  1 
HETATM 5695 C C9  . SPH D 4 .   ? 239.833 279.711 361.006 1.00 16.45 ? 401 SPH A C9  1 
HETATM 5696 C C10 . SPH D 4 .   ? 240.743 280.644 360.220 1.00 15.20 ? 401 SPH A C10 1 
HETATM 5697 C C11 . SPH D 4 .   ? 240.264 282.089 360.220 1.00 11.32 ? 401 SPH A C11 1 
HETATM 5698 C C12 . SPH D 4 .   ? 241.472 282.998 360.381 1.00 14.85 ? 401 SPH A C12 1 
HETATM 5699 C C13 . SPH D 4 .   ? 241.144 284.458 360.119 1.00 14.60 ? 401 SPH A C13 1 
HETATM 5700 C C14 . SPH D 4 .   ? 242.236 285.096 359.272 1.00 15.49 ? 401 SPH A C14 1 
HETATM 5701 C C15 . SPH D 4 .   ? 242.067 286.607 359.223 1.00 23.79 ? 401 SPH A C15 1 
HETATM 5702 C C16 . SPH D 4 .   ? 242.835 287.330 360.323 1.00 15.82 ? 401 SPH A C16 1 
HETATM 5703 C C17 . SPH D 4 .   ? 244.327 287.397 360.031 1.00 19.15 ? 401 SPH A C17 1 
HETATM 5704 C C18 . SPH D 4 .   ? 244.652 288.426 358.960 1.00 12.80 ? 401 SPH A C18 1 
HETATM 5705 O O   . HOH E 5 .   ? 225.760 280.539 371.169 1.00 17.29 ? 501 HOH A O   1 
HETATM 5706 O O   . HOH E 5 .   ? 230.807 283.030 367.730 1.00 11.00 ? 502 HOH A O   1 
HETATM 5707 O O   . HOH E 5 .   ? 253.299 275.530 369.995 1.00 16.17 ? 503 HOH A O   1 
HETATM 5708 O O   . HOH E 5 .   ? 240.602 302.120 371.010 1.00 11.90 ? 504 HOH A O   1 
HETATM 5709 O O   . HOH E 5 .   ? 225.816 259.192 367.987 1.00 5.52  ? 505 HOH A O   1 
HETATM 5710 O O   . HOH E 5 .   ? 212.479 278.384 347.992 1.00 6.28  ? 506 HOH A O   1 
HETATM 5711 O O   . HOH E 5 .   ? 236.088 277.705 356.103 1.00 8.63  ? 507 HOH A O   1 
HETATM 5712 O O   . HOH E 5 .   ? 226.714 281.335 351.346 1.00 15.78 ? 508 HOH A O   1 
HETATM 5713 O O   . HOH E 5 .   ? 244.990 299.630 356.972 1.00 14.16 ? 509 HOH A O   1 
HETATM 5714 O O   . HOH E 5 .   ? 219.950 271.337 365.802 1.00 6.99  ? 510 HOH A O   1 
HETATM 5715 O O   . HOH E 5 .   ? 226.746 273.070 376.667 1.00 19.13 ? 511 HOH A O   1 
HETATM 5716 O O   . HOH E 5 .   ? 223.270 273.986 374.331 1.00 8.59  ? 512 HOH A O   1 
HETATM 5717 O O   . HOH E 5 .   ? 231.751 288.010 356.397 1.00 5.51  ? 513 HOH A O   1 
HETATM 5718 O O   . HOH E 5 .   ? 245.677 307.409 377.967 1.00 29.90 ? 514 HOH A O   1 
HETATM 5719 O O   . HOH E 5 .   ? 232.400 297.307 365.976 1.00 9.34  ? 515 HOH A O   1 
HETATM 5720 O O   . HOH E 5 .   ? 245.680 279.710 368.520 1.00 17.91 ? 516 HOH A O   1 
HETATM 5721 O O   . HOH E 5 .   ? 218.290 276.035 377.850 1.00 16.32 ? 517 HOH A O   1 
HETATM 5722 O O   . HOH E 5 .   ? 233.118 276.546 366.864 1.00 22.19 ? 518 HOH A O   1 
HETATM 5723 O O   . HOH E 5 .   ? 241.040 311.150 365.512 1.00 21.87 ? 519 HOH A O   1 
HETATM 5724 O O   . HOH E 5 .   ? 220.819 272.824 367.765 1.00 9.19  ? 520 HOH A O   1 
HETATM 5725 O O   . HOH E 5 .   ? 228.793 263.909 350.081 1.00 14.18 ? 521 HOH A O   1 
HETATM 5726 O O   . HOH E 5 .   ? 239.040 260.730 356.053 1.00 10.78 ? 522 HOH A O   1 
HETATM 5727 O O   . HOH E 5 .   ? 234.890 267.287 361.808 1.00 18.83 ? 523 HOH A O   1 
HETATM 5728 O O   . HOH E 5 .   ? 248.170 278.937 369.415 1.00 13.31 ? 524 HOH A O   1 
HETATM 5729 O O   . HOH E 5 .   ? 235.748 276.828 367.527 1.00 19.05 ? 525 HOH A O   1 
HETATM 5730 O O   . HOH E 5 .   ? 225.997 282.200 366.030 1.00 12.18 ? 526 HOH A O   1 
HETATM 5731 O O   . HOH E 5 .   ? 234.115 301.739 358.799 1.00 9.22  ? 527 HOH A O   1 
HETATM 5732 O O   . HOH E 5 .   ? 239.041 278.051 367.420 1.00 11.28 ? 528 HOH A O   1 
HETATM 5733 O O   . HOH E 5 .   ? 219.919 280.540 372.669 1.00 17.27 ? 529 HOH A O   1 
HETATM 5734 O O   . HOH E 5 .   ? 237.380 283.725 373.111 1.00 18.99 ? 530 HOH A O   1 
HETATM 5735 O O   . HOH E 5 .   ? 235.388 282.273 371.736 1.00 18.21 ? 531 HOH A O   1 
HETATM 5736 O O   . HOH E 5 .   ? 239.871 308.760 364.370 1.00 17.26 ? 532 HOH A O   1 
HETATM 5737 O O   . HOH E 5 .   ? 241.704 299.630 356.827 1.00 9.16  ? 533 HOH A O   1 
HETATM 5738 O O   . HOH E 5 .   ? 222.437 266.431 369.350 1.00 12.26 ? 534 HOH A O   1 
HETATM 5739 O O   . HOH E 5 .   ? 240.729 271.434 354.751 1.00 5.77  ? 535 HOH A O   1 
HETATM 5740 O O   . HOH E 5 .   ? 220.617 284.690 350.260 1.00 16.93 ? 536 HOH A O   1 
HETATM 5741 O O   . HOH E 5 .   ? 234.891 299.358 360.403 1.00 11.91 ? 537 HOH A O   1 
HETATM 5742 O O   . HOH E 5 .   ? 220.712 268.891 366.902 1.00 5.59  ? 538 HOH A O   1 
HETATM 5743 O O   . HOH E 5 .   ? 235.237 304.326 354.567 1.00 16.62 ? 539 HOH A O   1 
HETATM 5744 O O   . HOH E 5 .   ? 218.518 286.453 349.430 1.00 10.99 ? 540 HOH A O   1 
HETATM 5745 O O   . HOH E 5 .   ? 240.600 306.270 365.650 1.00 14.33 ? 541 HOH A O   1 
HETATM 5746 O O   . HOH E 5 .   ? 213.081 271.410 366.860 1.00 11.21 ? 542 HOH A O   1 
HETATM 5747 O O   . HOH E 5 .   ? 219.803 274.414 365.199 1.00 10.16 ? 543 HOH A O   1 
HETATM 5748 O O   . HOH E 5 .   ? 229.860 268.162 369.981 1.00 18.09 ? 544 HOH A O   1 
HETATM 5749 O O   . HOH E 5 .   ? 239.870 271.312 361.880 1.00 25.06 ? 545 HOH A O   1 
HETATM 5750 O O   . HOH E 5 .   ? 221.525 281.146 374.488 1.00 12.93 ? 546 HOH A O   1 
HETATM 5751 O O   . HOH E 5 .   ? 249.531 294.513 377.383 1.00 16.55 ? 547 HOH A O   1 
HETATM 5752 O O   . HOH E 5 .   ? 234.372 271.067 363.403 1.00 15.01 ? 548 HOH A O   1 
HETATM 5753 O O   . HOH E 5 .   ? 213.300 280.900 346.110 1.00 10.80 ? 549 HOH A O   1 
HETATM 5754 O O   . HOH E 5 .   ? 239.848 297.974 355.373 1.00 8.19  ? 550 HOH A O   1 
HETATM 5755 O O   . HOH E 5 .   ? 235.433 302.867 361.487 1.00 13.10 ? 551 HOH A O   1 
HETATM 5756 O O   . HOH E 5 .   ? 224.641 272.532 370.180 1.00 14.21 ? 552 HOH A O   1 
HETATM 5757 O O   . HOH E 5 .   ? 221.610 284.176 347.770 1.00 19.59 ? 553 HOH A O   1 
HETATM 5758 O O   . HOH E 5 .   ? 246.584 294.845 378.480 1.00 23.77 ? 554 HOH A O   1 
HETATM 5759 O O   . HOH E 5 .   ? 237.288 269.445 360.186 1.00 15.21 ? 555 HOH A O   1 
HETATM 5760 O O   . HOH E 5 .   ? 221.761 271.704 370.180 1.00 13.30 ? 556 HOH A O   1 
HETATM 5761 O O   . HOH E 5 .   ? 230.435 271.184 371.840 1.00 21.37 ? 557 HOH A O   1 
HETATM 5762 O O   . HOH E 5 .   ? 260.188 289.603 362.019 1.00 18.34 ? 558 HOH A O   1 
HETATM 5763 O O   . HOH F 5 .   ? 233.230 255.567 366.030 1.00 17.69 ? 401 HOH B O   1 
HETATM 5764 O O   . HOH F 5 .   ? 219.120 266.430 367.394 1.00 18.55 ? 402 HOH B O   1 
HETATM 5765 O O   . HOH F 5 .   ? 232.351 254.391 371.534 1.00 23.81 ? 403 HOH B O   1 
HETATM 5766 O O   . HOH F 5 .   ? 244.850 246.918 360.220 1.00 24.56 ? 404 HOH B O   1 
HETATM 5767 O O   . HOH F 5 .   ? 234.401 252.240 375.160 1.00 19.96 ? 405 HOH B O   1 
HETATM 5768 O O   . HOH F 5 .   ? 208.331 259.977 376.127 1.00 17.09 ? 406 HOH B O   1 
HETATM 5769 O O   . HOH F 5 .   ? 230.052 259.851 363.089 1.00 14.51 ? 407 HOH B O   1 
HETATM 5770 O O   . HOH F 5 .   ? 230.448 253.150 363.326 1.00 16.83 ? 408 HOH B O   1 
HETATM 5771 O O   . HOH F 5 .   ? 226.590 269.547 396.905 1.00 35.28 ? 409 HOH B O   1 
HETATM 5772 O O   . HOH F 5 .   ? 204.789 256.470 377.315 1.00 16.52 ? 410 HOH B O   1 
HETATM 5773 O O   . HOH F 5 .   ? 249.830 248.845 364.244 1.00 14.26 ? 411 HOH B O   1 
HETATM 5774 O O   . HOH F 5 .   ? 207.395 242.256 372.431 1.00 13.23 ? 412 HOH B O   1 
HETATM 5775 O O   . HOH F 5 .   ? 197.540 254.418 373.612 1.00 23.61 ? 413 HOH B O   1 
HETATM 5776 O O   . HOH F 5 .   ? 199.203 241.558 366.860 1.00 14.74 ? 414 HOH B O   1 
HETATM 5777 O O   . HOH F 5 .   ? 234.620 243.402 373.958 1.00 21.36 ? 415 HOH B O   1 
HETATM 5778 O O   . HOH F 5 .   ? 234.068 257.371 353.500 1.00 21.58 ? 416 HOH B O   1 
HETATM 5779 O O   . HOH F 5 .   ? 222.440 254.503 380.970 1.00 15.59 ? 417 HOH B O   1 
HETATM 5780 O O   . HOH F 5 .   ? 240.632 250.764 370.484 1.00 17.88 ? 418 HOH B O   1 
HETATM 5781 O O   . HOH F 5 .   ? 244.229 260.346 367.358 1.00 14.94 ? 419 HOH B O   1 
HETATM 5782 O O   . HOH F 5 .   ? 234.625 255.469 363.540 1.00 9.61  ? 420 HOH B O   1 
HETATM 5783 O O   . HOH F 5 .   ? 217.388 244.019 373.058 1.00 13.84 ? 421 HOH B O   1 
HETATM 5784 O O   . HOH F 5 .   ? 224.930 252.329 374.145 1.00 3.48  ? 422 HOH B O   1 
HETATM 5785 O O   . HOH F 5 .   ? 226.589 265.853 382.690 1.00 17.50 ? 423 HOH B O   1 
HETATM 5786 O O   . HOH F 5 .   ? 213.819 261.257 357.730 1.00 15.04 ? 424 HOH B O   1 
HETATM 5787 O O   . HOH F 5 .   ? 229.080 255.428 354.410 1.00 20.18 ? 425 HOH B O   1 
HETATM 5788 O O   . HOH F 5 .   ? 228.065 245.070 373.810 1.00 7.47  ? 426 HOH B O   1 
HETATM 5789 O O   . HOH F 5 .   ? 218.030 251.548 377.887 1.00 15.20 ? 427 HOH B O   1 
HETATM 5790 O O   . HOH F 5 .   ? 232.578 265.525 380.263 1.00 22.49 ? 428 HOH B O   1 
HETATM 5791 O O   . HOH F 5 .   ? 204.179 253.979 376.820 1.00 12.63 ? 429 HOH B O   1 
HETATM 5792 O O   . HOH F 5 .   ? 231.570 237.490 367.072 1.00 9.85  ? 430 HOH B O   1 
HETATM 5793 O O   . HOH F 5 .   ? 196.824 246.125 367.689 1.00 7.47  ? 431 HOH B O   1 
HETATM 5794 O O   . HOH F 5 .   ? 226.590 266.181 387.419 1.00 23.75 ? 432 HOH B O   1 
HETATM 5795 O O   . HOH F 5 .   ? 232.400 258.130 373.250 1.00 14.85 ? 433 HOH B O   1 
HETATM 5796 O O   . HOH F 5 .   ? 232.492 258.960 356.373 1.00 20.40 ? 434 HOH B O   1 
HETATM 5797 O O   . HOH F 5 .   ? 238.691 245.744 376.054 1.00 17.99 ? 435 HOH B O   1 
HETATM 5798 O O   . HOH F 5 .   ? 223.018 240.700 374.961 1.00 19.67 ? 436 HOH B O   1 
HETATM 5799 O O   . HOH F 5 .   ? 221.610 269.828 380.140 1.00 11.33 ? 437 HOH B O   1 
HETATM 5800 O O   . HOH F 5 .   ? 211.827 253.980 378.872 1.00 13.22 ? 438 HOH B O   1 
HETATM 5801 O O   . HOH F 5 .   ? 217.159 258.960 355.735 1.00 16.36 ? 439 HOH B O   1 
HETATM 5802 O O   . HOH F 5 .   ? 198.234 244.126 365.848 1.00 15.16 ? 440 HOH B O   1 
HETATM 5803 O O   . HOH F 5 .   ? 221.538 238.210 367.263 1.00 9.20  ? 441 HOH B O   1 
HETATM 5804 O O   . HOH F 5 .   ? 225.760 247.709 379.258 1.00 19.68 ? 442 HOH B O   1 
HETATM 5805 O O   . HOH F 5 .   ? 227.369 254.601 352.075 1.00 16.28 ? 443 HOH B O   1 
HETATM 5806 O O   . HOH F 5 .   ? 217.369 240.340 377.680 1.00 16.67 ? 444 HOH B O   1 
HETATM 5807 O O   . HOH F 5 .   ? 228.051 246.421 376.416 1.00 19.53 ? 445 HOH B O   1 
HETATM 5808 O O   . HOH F 5 .   ? 224.194 269.947 381.271 1.00 19.32 ? 446 HOH B O   1 
HETATM 5809 O O   . HOH F 5 .   ? 232.105 252.688 373.704 1.00 18.98 ? 447 HOH B O   1 
HETATM 5810 O O   . HOH F 5 .   ? 233.522 251.489 377.650 1.00 17.03 ? 448 HOH B O   1 
HETATM 5811 O O   . HOH F 5 .   ? 191.730 250.563 370.425 1.00 16.24 ? 449 HOH B O   1 
HETATM 5812 O O   . HOH F 5 .   ? 213.311 258.085 357.730 1.00 16.03 ? 450 HOH B O   1 
HETATM 5813 O O   . HOH F 5 .   ? 229.172 252.553 355.283 1.00 14.08 ? 451 HOH B O   1 
HETATM 5814 O O   . HOH F 5 .   ? 238.588 251.490 367.060 1.00 16.84 ? 452 HOH B O   1 
HETATM 5815 O O   . HOH F 5 .   ? 244.613 249.692 377.343 1.00 12.91 ? 453 HOH B O   1 
HETATM 5816 O O   . HOH F 5 .   ? 229.604 259.243 372.993 1.00 15.98 ? 454 HOH B O   1 
HETATM 5817 O O   . HOH F 5 .   ? 196.678 239.040 368.385 1.00 15.46 ? 455 HOH B O   1 
HETATM 5818 O O   . HOH F 5 .   ? 246.683 243.284 374.330 1.00 10.20 ? 456 HOH B O   1 
HETATM 5819 O O   . HOH F 5 .   ? 220.066 239.270 376.455 1.00 19.42 ? 457 HOH B O   1 
HETATM 5820 O O   . HOH F 5 .   ? 207.092 264.768 378.108 1.00 15.76 ? 458 HOH B O   1 
HETATM 5821 O O   . HOH F 5 .   ? 231.321 250.680 356.900 1.00 21.35 ? 459 HOH B O   1 
HETATM 5822 O O   . HOH F 5 .   ? 228.815 234.890 362.093 1.00 20.06 ? 460 HOH B O   1 
HETATM 5823 O O   . HOH F 5 .   ? 213.507 247.474 380.970 1.00 20.49 ? 461 HOH B O   1 
HETATM 5824 O O   . HOH F 5 .   ? 226.835 268.762 380.971 1.00 19.95 ? 462 HOH B O   1 
HETATM 5825 O O   . HOH F 5 .   ? 220.917 269.100 369.564 1.00 10.82 ? 463 HOH B O   1 
HETATM 5826 O O   . HOH F 5 .   ? 233.154 252.978 379.908 1.00 28.37 ? 464 HOH B O   1 
HETATM 5827 O O   . HOH F 5 .   ? 223.444 231.876 358.560 1.00 27.83 ? 465 HOH B O   1 
HETATM 5828 O O   . HOH F 5 .   ? 220.780 238.246 374.027 1.00 17.36 ? 466 HOH B O   1 
HETATM 5829 O O   . HOH F 5 .   ? 205.837 243.586 361.050 1.00 20.38 ? 467 HOH B O   1 
HETATM 5830 O O   . HOH F 5 .   ? 224.100 259.994 349.164 1.00 16.73 ? 468 HOH B O   1 
HETATM 5831 O O   . HOH F 5 .   ? 228.869 243.190 356.070 1.00 23.10 ? 469 HOH B O   1 
HETATM 5832 O O   . HOH F 5 .   ? 216.630 260.867 356.900 1.00 16.45 ? 470 HOH B O   1 
HETATM 5833 O O   . HOH F 5 .   ? 230.184 232.848 361.050 1.00 19.37 ? 471 HOH B O   1 
HETATM 5834 O O   . HOH G 5 .   ? 244.447 279.090 350.260 1.00 13.46 ? 301 HOH C O   1 
HETATM 5835 O O   . HOH G 5 .   ? 206.000 283.761 361.880 1.00 14.67 ? 302 HOH C O   1 
HETATM 5836 O O   . HOH G 5 .   ? 210.820 273.443 366.860 1.00 13.93 ? 303 HOH C O   1 
HETATM 5837 O O   . HOH G 5 .   ? 196.591 284.377 350.545 1.00 10.03 ? 304 HOH C O   1 
HETATM 5838 O O   . HOH G 5 .   ? 185.090 278.234 356.756 1.00 11.64 ? 305 HOH C O   1 
HETATM 5839 O O   . HOH G 5 .   ? 206.075 281.370 364.429 1.00 19.07 ? 306 HOH C O   1 
HETATM 5840 O O   . HOH G 5 .   ? 209.938 283.877 362.990 1.00 13.03 ? 307 HOH C O   1 
HETATM 5841 O O   . HOH G 5 .   ? 216.632 285.329 365.877 1.00 14.57 ? 308 HOH C O   1 
HETATM 5842 O O   . HOH G 5 .   ? 235.357 292.362 349.430 1.00 12.83 ? 309 HOH C O   1 
HETATM 5843 O O   . HOH G 5 .   ? 222.339 260.620 351.005 1.00 0.01  ? 310 HOH C O   1 
HETATM 5844 O O   . HOH G 5 .   ? 200.860 264.770 366.043 1.00 14.48 ? 311 HOH C O   1 
HETATM 5845 O O   . HOH G 5 .   ? 195.474 281.051 357.807 1.00 20.75 ? 312 HOH C O   1 
HETATM 5846 O O   . HOH G 5 .   ? 214.140 285.843 368.215 1.00 19.48 ? 313 HOH C O   1 
HETATM 5847 O O   . HOH G 5 .   ? 204.416 273.893 366.031 1.00 7.65  ? 314 HOH C O   1 
HETATM 5848 O O   . HOH G 5 .   ? 199.554 284.870 356.196 1.00 16.25 ? 315 HOH C O   1 
HETATM 5849 O O   . HOH G 5 .   ? 231.095 298.512 349.634 1.00 5.34  ? 316 HOH C O   1 
HETATM 5850 O O   . HOH G 5 .   ? 229.159 295.678 351.090 1.00 3.31  ? 317 HOH C O   1 
HETATM 5851 O O   . HOH G 5 .   ? 182.600 264.771 364.371 1.00 9.14  ? 318 HOH C O   1 
HETATM 5852 O O   . HOH G 5 .   ? 219.011 281.586 363.649 1.00 12.80 ? 319 HOH C O   1 
HETATM 5853 O O   . HOH G 5 .   ? 205.750 259.245 376.051 1.00 17.41 ? 320 HOH C O   1 
HETATM 5854 O O   . HOH G 5 .   ? 212.881 278.895 362.710 1.00 10.41 ? 321 HOH C O   1 
HETATM 5855 O O   . HOH G 5 .   ? 207.539 269.316 358.603 1.00 12.16 ? 322 HOH C O   1 
HETATM 5856 O O   . HOH G 5 .   ? 225.149 270.579 350.260 1.00 2.59  ? 323 HOH C O   1 
HETATM 5857 O O   . HOH G 5 .   ? 230.887 289.477 350.213 1.00 10.84 ? 324 HOH C O   1 
HETATM 5858 O O   . HOH G 5 .   ? 225.789 263.940 347.770 1.00 14.22 ? 325 HOH C O   1 
HETATM 5859 O O   . HOH G 5 .   ? 229.339 289.339 355.095 1.00 16.63 ? 326 HOH C O   1 
HETATM 5860 O O   . HOH G 5 .   ? 225.071 262.323 350.284 1.00 6.13  ? 327 HOH C O   1 
HETATM 5861 O O   . HOH G 5 .   ? 246.511 286.350 349.824 1.00 10.93 ? 328 HOH C O   1 
HETATM 5862 O O   . HOH G 5 .   ? 227.852 296.169 343.717 1.00 14.37 ? 329 HOH C O   1 
HETATM 5863 O O   . HOH G 5 .   ? 231.521 286.820 348.600 1.00 22.89 ? 330 HOH C O   1 
HETATM 5864 O O   . HOH G 5 .   ? 183.673 257.653 368.326 1.00 16.04 ? 331 HOH C O   1 
HETATM 5865 O O   . HOH G 5 .   ? 199.200 258.207 354.410 1.00 24.49 ? 332 HOH C O   1 
HETATM 5866 O O   . HOH G 5 .   ? 224.930 287.180 349.683 1.00 17.16 ? 333 HOH C O   1 
HETATM 5867 O O   . HOH G 5 .   ? 186.291 247.341 374.773 1.00 13.50 ? 334 HOH C O   1 
HETATM 5868 O O   . HOH G 5 .   ? 200.860 282.050 356.210 1.00 15.39 ? 335 HOH C O   1 
HETATM 5869 O O   . HOH G 5 .   ? 206.676 291.330 352.298 1.00 24.77 ? 336 HOH C O   1 
HETATM 5870 O O   . HOH G 5 .   ? 193.002 264.774 373.020 1.00 17.44 ? 337 HOH C O   1 
HETATM 5871 O O   . HOH G 5 .   ? 186.619 241.311 371.520 1.00 9.35  ? 338 HOH C O   1 
HETATM 5872 O O   . HOH G 5 .   ? 192.942 280.909 358.970 1.00 23.38 ? 339 HOH C O   1 
HETATM 5873 O O   . HOH G 5 .   ? 198.379 274.916 350.385 1.00 12.22 ? 340 HOH C O   1 
HETATM 5874 O O   . HOH G 5 .   ? 227.420 292.164 346.028 1.00 14.35 ? 341 HOH C O   1 
HETATM 5875 O O   . HOH G 5 .   ? 196.010 273.012 370.181 1.00 16.34 ? 342 HOH C O   1 
HETATM 5876 O O   . HOH G 5 .   ? 196.710 254.848 371.010 1.00 12.75 ? 343 HOH C O   1 
HETATM 5877 O O   . HOH G 5 .   ? 198.662 250.661 367.690 1.00 9.38  ? 344 HOH C O   1 
HETATM 5878 O O   . HOH G 5 .   ? 228.700 297.167 348.600 1.00 11.80 ? 345 HOH C O   1 
HETATM 5879 O O   . HOH G 5 .   ? 198.241 281.704 356.070 1.00 15.62 ? 346 HOH C O   1 
HETATM 5880 O O   . HOH G 5 .   ? 194.733 271.411 367.181 1.00 18.00 ? 347 HOH C O   1 
HETATM 5881 O O   . HOH G 5 .   ? 188.265 272.830 357.731 1.00 10.48 ? 348 HOH C O   1 
HETATM 5882 O O   . HOH G 5 .   ? 189.310 265.888 348.188 1.00 19.63 ? 349 HOH C O   1 
HETATM 5883 O O   . HOH G 5 .   ? 233.177 265.800 352.770 1.00 17.91 ? 350 HOH C O   1 
HETATM 5884 O O   . HOH G 5 .   ? 182.646 250.660 370.308 1.00 7.49  ? 351 HOH C O   1 
HETATM 5885 O O   . HOH G 5 .   ? 189.287 251.865 377.604 1.00 21.34 ? 352 HOH C O   1 
HETATM 5886 O O   . HOH G 5 .   ? 192.705 268.112 374.922 1.00 22.54 ? 353 HOH C O   1 
HETATM 5887 O O   . HOH G 5 .   ? 195.735 284.884 341.960 1.00 19.59 ? 354 HOH C O   1 
HETATM 5888 O O   . HOH G 5 .   ? 204.935 266.430 346.518 1.00 22.47 ? 355 HOH C O   1 
HETATM 5889 O O   . HOH G 5 .   ? 195.946 277.170 350.260 1.00 9.41  ? 356 HOH C O   1 
HETATM 5890 O O   . HOH G 5 .   ? 183.521 241.576 371.799 1.00 9.38  ? 357 HOH C O   1 
HETATM 5891 O O   . HOH G 5 .   ? 182.247 260.272 368.042 1.00 20.68 ? 358 HOH C O   1 
HETATM 5892 O O   . HOH G 5 .   ? 231.570 258.531 353.579 1.00 19.82 ? 359 HOH C O   1 
HETATM 5893 O O   . HOH G 5 .   ? 217.612 284.229 363.539 1.00 11.74 ? 360 HOH C O   1 
HETATM 5894 O O   . HOH G 5 .   ? 202.109 281.531 358.596 1.00 13.63 ? 361 HOH C O   1 
HETATM 5895 O O   . HOH G 5 .   ? 218.877 273.538 345.346 1.00 20.48 ? 362 HOH C O   1 
HETATM 5896 O O   . HOH G 5 .   ? 244.765 268.090 351.685 1.00 19.65 ? 363 HOH C O   1 
HETATM 5897 O O   . HOH G 5 .   ? 208.457 262.439 354.528 1.00 23.76 ? 364 HOH C O   1 
HETATM 5898 O O   . HOH G 5 .   ? 210.824 263.245 352.627 1.00 22.00 ? 365 HOH C O   1 
# 
