data_9H93
# 
_entry.id   9H93 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9H93         pdb_00009h93 10.2210/pdb9h93/pdb 
WWPDB D_1292142771 ?            ?                   
EMDB  EMD-51951    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-04-02 ? 
2 'EM metadata'     1 0 2025-04-02 ? 
3 FSC               1 0 2025-04-02 ? 
4 'Half map'        1 0 2025-04-02 1 
5 'Half map'        1 0 2025-04-02 2 
6 Image             1 0 2025-04-02 ? 
7 'Primary map'     1 0 2025-04-02 ? 
8 'Structure model' 1 1 2025-04-09 ? 
# 
loop_
_pdbx_audit_revision_details.ordinal 
_pdbx_audit_revision_details.revision_ordinal 
_pdbx_audit_revision_details.data_content_type 
_pdbx_audit_revision_details.provider 
_pdbx_audit_revision_details.type 
_pdbx_audit_revision_details.description 
_pdbx_audit_revision_details.details 
1 1 'Structure model' repository 'Initial release' ? ? 
2 2 'EM metadata'     repository 'Initial release' ? ? 
3 3 FSC               repository 'Initial release' ? ? 
4 4 'Half map'        repository 'Initial release' ? ? 
5 5 'Half map'        repository 'Initial release' ? ? 
6 6 Image             repository 'Initial release' ? ? 
7 7 'Primary map'     repository 'Initial release' ? ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 8 'Structure model' 'Data collection'     
2 8 'Structure model' 'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 8 'Structure model' citation        
2 8 'Structure model' citation_author 
3 8 'Structure model' em_admin        
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  8 'Structure model' '_citation.country'                 
2  8 'Structure model' '_citation.journal_abbrev'          
3  8 'Structure model' '_citation.journal_id_CSD'          
4  8 'Structure model' '_citation.journal_id_ISSN'         
5  8 'Structure model' '_citation.journal_volume'          
6  8 'Structure model' '_citation.page_first'              
7  8 'Structure model' '_citation.page_last'               
8  8 'Structure model' '_citation.pdbx_database_id_DOI'    
9  8 'Structure model' '_citation.pdbx_database_id_PubMed' 
10 8 'Structure model' '_citation.title'                   
11 8 'Structure model' '_citation.year'                    
12 8 'Structure model' '_em_admin.last_update'             
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9H93 
_pdbx_database_status.recvd_initial_deposition_date   2024-10-29 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        
'Poliovirus type 2 (strain MEF-1) stabilised virus-like particle (PV2 SC6b) from a yeast expression system.' 
_pdbx_database_related.db_id          EMD-51951 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              dave.stuart@strubi.ox.ac.uk 
_pdbx_contact_author.name_first         David 
_pdbx_contact_author.name_last          Stuart 
_pdbx_contact_author.name_mi            I. 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-3426-4210 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Bahar, M.W.'      1 0000-0002-2350-2682 
'Sherry, L.'       2 0000-0002-4367-772X 
'Stonehouse, N.J.' 3 0000-0003-1146-5519 
'Rowlands, D.J.'   4 0000-0002-4742-9272 
'Fry, E.E.'        5 0000-0001-9754-5303 
'Stuart, D.I.'     6 0000-0002-3426-4210 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Npj Vaccines' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2059-0105 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            10 
_citation.language                  ? 
_citation.page_first                64 
_citation.page_last                 64 
_citation.title                     
'Production of an immunogenic trivalent poliovirus virus-like particle vaccine candidate in yeast using controlled fermentation.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41541-025-01111-2 
_citation.pdbx_database_id_PubMed   40164627 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Sherry, L.'       1  ? 
primary 'Grehan, K.'       2  ? 
primary 'Bahar, M.W.'      3  ? 
primary 'Swanson, J.J.'    4  ? 
primary 'Fox, H.'          5  ? 
primary 'Matthews, S.'     6  ? 
primary 'Carlyle, S.'      7  ? 
primary 'Qin, L.'          8  ? 
primary 'Porta, C.'        9  ? 
primary 'Wilkinson, S.'    10 ? 
primary 'Robb, S.'         11 ? 
primary 'Clark, N.'        12 ? 
primary 'Liddell, J.'      13 ? 
primary 'Fry, E.E.'        14 ? 
primary 'Stuart, D.I.'     15 ? 
primary 'Macadam, A.J.'    16 ? 
primary 'Rowlands, D.J.'   17 ? 
primary 'Stonehouse, N.J.' 18 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Capsid protein VP1'  33105.246 1 ? 'VP1 V107I, VP1 F134L, VP1 V183L' ? ? 
2 polymer     man 'Capsid protein, VP0' 37398.816 1 ? 'VP4 I57V, VP2 D57A'              ? ? 
3 polymer     man 'Capsid protein VP3'  26457.322 1 ? 'VP3 Q178L'                       ? ? 
4 non-polymer syn SPHINGOSINE           299.492   1 ? ?                                 ? ? 
# 
loop_
_entity_name_com.entity_id 
_entity_name_com.name 
1 'Capsid protein VP1'  
2 'Capsid protein, VP0' 
3 'Capsid protein VP3'  
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;GLGDLIEGVVEGVTRNALTPLTPANNLPDTQSSGPAHSKETPALTAVETGATNPLVPSDTVQTRHVIQKRTRSESTVESF
FARGACVAIIEVDNDAPTKRASKLFSIWKITYKDTVQLRRKLEFFTYSRFDMELTFVVTSNYTDANNGHALNQVYQIMYI
PPGAPIPGKWNDYTWQTSSNPSLFYTYGAPPARISVPYVGIANAYSHFYDGFAKVPLAGQASTEGDSLYGAASLNDFGSL
AVRVVNDHNPTKLTSKIRVYMKPKHVRVWCPRPPRAVPYYGPGVDYKDGLAPLPEKGLTTY
;
;GLGDLIEGVVEGVTRNALTPLTPANNLPDTQSSGPAHSKETPALTAVETGATNPLVPSDTVQTRHVIQKRTRSESTVESF
FARGACVAIIEVDNDAPTKRASKLFSIWKITYKDTVQLRRKLEFFTYSRFDMELTFVVTSNYTDANNGHALNQVYQIMYI
PPGAPIPGKWNDYTWQTSSNPSLFYTYGAPPARISVPYVGIANAYSHFYDGFAKVPLAGQASTEGDSLYGAASLNDFGSL
AVRVVNDHNPTKLTSKIRVYMKPKHVRVWCPRPPRAVPYYGPGVDYKDGLAPLPEKGLTTY
;
A ? 
2 'polypeptide(L)' no no 
;MGAQVSSQKVGAHENSNRAYGGSTINYTTINYYRDSASNAASKQDFAQDPSKFTEPVKDVLIKTAPTLNSPNIEACGYSD
RVMQLTLGNSTITTQEAANSVVAYGRWPEYIKDSEANPVDQPTEPAVAACRFYTLDTVTWRKESRGWWWKLPDALKDMGL
FGQNMFYHYLGRAGYTVHVQCNASKFHQGALGVFAVPEMCLAGDSTTHMFTKYENANPGEKGGEFKGSFTLDTNATNPAR
NFCPVDYLFGSGVLAGNAFVYPHQIINLRTNNCATLVLPYVNSLSIDSMTKHNNWGIAILPLAPLDFATESSTEIPITLT
IAPMCCEFNGLRNITVPRTQ
;
;MGAQVSSQKVGAHENSNRAYGGSTINYTTINYYRDSASNAASKQDFAQDPSKFTEPVKDVLIKTAPTLNSPNIEACGYSD
RVMQLTLGNSTITTQEAANSVVAYGRWPEYIKDSEANPVDQPTEPAVAACRFYTLDTVTWRKESRGWWWKLPDALKDMGL
FGQNMFYHYLGRAGYTVHVQCNASKFHQGALGVFAVPEMCLAGDSTTHMFTKYENANPGEKGGEFKGSFTLDTNATNPAR
NFCPVDYLFGSGVLAGNAFVYPHQIINLRTNNCATLVLPYVNSLSIDSMTKHNNWGIAILPLAPLDFATESSTEIPITLT
IAPMCCEFNGLRNITVPRTQ
;
B ? 
3 'polypeptide(L)' no no 
;GLPVLNTPGSNQYLTADNYQSPCAIPEFDVTPPIDIPGEVRNMMELAEIDTMIPLNLTNQRKNTMDMYRVELNDAAHSDT
PILCLSLSPASDPRLAHTMLGEILNYYTHWAGSLKFTFLFCGSMMATGKLLVSYAPPGAEAPKSRKEAMLGTHVIWDIGL
QSSCTMVVPWISNTTYRLTINDSFTEGGYISMFYQTRVVVPLSTPRKMDILGFVSACNDFSVRLLRDTTHISQEAMPQ
;
;GLPVLNTPGSNQYLTADNYQSPCAIPEFDVTPPIDIPGEVRNMMELAEIDTMIPLNLTNQRKNTMDMYRVELNDAAHSDT
PILCLSLSPASDPRLAHTMLGEILNYYTHWAGSLKFTFLFCGSMMATGKLLVSYAPPGAEAPKSRKEAMLGTHVIWDIGL
QSSCTMVVPWISNTTYRLTINDSFTEGGYISMFYQTRVVVPLSTPRKMDILGFVSACNDFSVRLLRDTTHISQEAMPQ
;
C ? 
# 
_pdbx_entity_nonpoly.entity_id   4 
_pdbx_entity_nonpoly.name        SPHINGOSINE 
_pdbx_entity_nonpoly.comp_id     SPH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   LEU n 
1 3   GLY n 
1 4   ASP n 
1 5   LEU n 
1 6   ILE n 
1 7   GLU n 
1 8   GLY n 
1 9   VAL n 
1 10  VAL n 
1 11  GLU n 
1 12  GLY n 
1 13  VAL n 
1 14  THR n 
1 15  ARG n 
1 16  ASN n 
1 17  ALA n 
1 18  LEU n 
1 19  THR n 
1 20  PRO n 
1 21  LEU n 
1 22  THR n 
1 23  PRO n 
1 24  ALA n 
1 25  ASN n 
1 26  ASN n 
1 27  LEU n 
1 28  PRO n 
1 29  ASP n 
1 30  THR n 
1 31  GLN n 
1 32  SER n 
1 33  SER n 
1 34  GLY n 
1 35  PRO n 
1 36  ALA n 
1 37  HIS n 
1 38  SER n 
1 39  LYS n 
1 40  GLU n 
1 41  THR n 
1 42  PRO n 
1 43  ALA n 
1 44  LEU n 
1 45  THR n 
1 46  ALA n 
1 47  VAL n 
1 48  GLU n 
1 49  THR n 
1 50  GLY n 
1 51  ALA n 
1 52  THR n 
1 53  ASN n 
1 54  PRO n 
1 55  LEU n 
1 56  VAL n 
1 57  PRO n 
1 58  SER n 
1 59  ASP n 
1 60  THR n 
1 61  VAL n 
1 62  GLN n 
1 63  THR n 
1 64  ARG n 
1 65  HIS n 
1 66  VAL n 
1 67  ILE n 
1 68  GLN n 
1 69  LYS n 
1 70  ARG n 
1 71  THR n 
1 72  ARG n 
1 73  SER n 
1 74  GLU n 
1 75  SER n 
1 76  THR n 
1 77  VAL n 
1 78  GLU n 
1 79  SER n 
1 80  PHE n 
1 81  PHE n 
1 82  ALA n 
1 83  ARG n 
1 84  GLY n 
1 85  ALA n 
1 86  CYS n 
1 87  VAL n 
1 88  ALA n 
1 89  ILE n 
1 90  ILE n 
1 91  GLU n 
1 92  VAL n 
1 93  ASP n 
1 94  ASN n 
1 95  ASP n 
1 96  ALA n 
1 97  PRO n 
1 98  THR n 
1 99  LYS n 
1 100 ARG n 
1 101 ALA n 
1 102 SER n 
1 103 LYS n 
1 104 LEU n 
1 105 PHE n 
1 106 SER n 
1 107 ILE n 
1 108 TRP n 
1 109 LYS n 
1 110 ILE n 
1 111 THR n 
1 112 TYR n 
1 113 LYS n 
1 114 ASP n 
1 115 THR n 
1 116 VAL n 
1 117 GLN n 
1 118 LEU n 
1 119 ARG n 
1 120 ARG n 
1 121 LYS n 
1 122 LEU n 
1 123 GLU n 
1 124 PHE n 
1 125 PHE n 
1 126 THR n 
1 127 TYR n 
1 128 SER n 
1 129 ARG n 
1 130 PHE n 
1 131 ASP n 
1 132 MET n 
1 133 GLU n 
1 134 LEU n 
1 135 THR n 
1 136 PHE n 
1 137 VAL n 
1 138 VAL n 
1 139 THR n 
1 140 SER n 
1 141 ASN n 
1 142 TYR n 
1 143 THR n 
1 144 ASP n 
1 145 ALA n 
1 146 ASN n 
1 147 ASN n 
1 148 GLY n 
1 149 HIS n 
1 150 ALA n 
1 151 LEU n 
1 152 ASN n 
1 153 GLN n 
1 154 VAL n 
1 155 TYR n 
1 156 GLN n 
1 157 ILE n 
1 158 MET n 
1 159 TYR n 
1 160 ILE n 
1 161 PRO n 
1 162 PRO n 
1 163 GLY n 
1 164 ALA n 
1 165 PRO n 
1 166 ILE n 
1 167 PRO n 
1 168 GLY n 
1 169 LYS n 
1 170 TRP n 
1 171 ASN n 
1 172 ASP n 
1 173 TYR n 
1 174 THR n 
1 175 TRP n 
1 176 GLN n 
1 177 THR n 
1 178 SER n 
1 179 SER n 
1 180 ASN n 
1 181 PRO n 
1 182 SER n 
1 183 LEU n 
1 184 PHE n 
1 185 TYR n 
1 186 THR n 
1 187 TYR n 
1 188 GLY n 
1 189 ALA n 
1 190 PRO n 
1 191 PRO n 
1 192 ALA n 
1 193 ARG n 
1 194 ILE n 
1 195 SER n 
1 196 VAL n 
1 197 PRO n 
1 198 TYR n 
1 199 VAL n 
1 200 GLY n 
1 201 ILE n 
1 202 ALA n 
1 203 ASN n 
1 204 ALA n 
1 205 TYR n 
1 206 SER n 
1 207 HIS n 
1 208 PHE n 
1 209 TYR n 
1 210 ASP n 
1 211 GLY n 
1 212 PHE n 
1 213 ALA n 
1 214 LYS n 
1 215 VAL n 
1 216 PRO n 
1 217 LEU n 
1 218 ALA n 
1 219 GLY n 
1 220 GLN n 
1 221 ALA n 
1 222 SER n 
1 223 THR n 
1 224 GLU n 
1 225 GLY n 
1 226 ASP n 
1 227 SER n 
1 228 LEU n 
1 229 TYR n 
1 230 GLY n 
1 231 ALA n 
1 232 ALA n 
1 233 SER n 
1 234 LEU n 
1 235 ASN n 
1 236 ASP n 
1 237 PHE n 
1 238 GLY n 
1 239 SER n 
1 240 LEU n 
1 241 ALA n 
1 242 VAL n 
1 243 ARG n 
1 244 VAL n 
1 245 VAL n 
1 246 ASN n 
1 247 ASP n 
1 248 HIS n 
1 249 ASN n 
1 250 PRO n 
1 251 THR n 
1 252 LYS n 
1 253 LEU n 
1 254 THR n 
1 255 SER n 
1 256 LYS n 
1 257 ILE n 
1 258 ARG n 
1 259 VAL n 
1 260 TYR n 
1 261 MET n 
1 262 LYS n 
1 263 PRO n 
1 264 LYS n 
1 265 HIS n 
1 266 VAL n 
1 267 ARG n 
1 268 VAL n 
1 269 TRP n 
1 270 CYS n 
1 271 PRO n 
1 272 ARG n 
1 273 PRO n 
1 274 PRO n 
1 275 ARG n 
1 276 ALA n 
1 277 VAL n 
1 278 PRO n 
1 279 TYR n 
1 280 TYR n 
1 281 GLY n 
1 282 PRO n 
1 283 GLY n 
1 284 VAL n 
1 285 ASP n 
1 286 TYR n 
1 287 LYS n 
1 288 ASP n 
1 289 GLY n 
1 290 LEU n 
1 291 ALA n 
1 292 PRO n 
1 293 LEU n 
1 294 PRO n 
1 295 GLU n 
1 296 LYS n 
1 297 GLY n 
1 298 LEU n 
1 299 THR n 
1 300 THR n 
1 301 TYR n 
2 1   MET n 
2 2   GLY n 
2 3   ALA n 
2 4   GLN n 
2 5   VAL n 
2 6   SER n 
2 7   SER n 
2 8   GLN n 
2 9   LYS n 
2 10  VAL n 
2 11  GLY n 
2 12  ALA n 
2 13  HIS n 
2 14  GLU n 
2 15  ASN n 
2 16  SER n 
2 17  ASN n 
2 18  ARG n 
2 19  ALA n 
2 20  TYR n 
2 21  GLY n 
2 22  GLY n 
2 23  SER n 
2 24  THR n 
2 25  ILE n 
2 26  ASN n 
2 27  TYR n 
2 28  THR n 
2 29  THR n 
2 30  ILE n 
2 31  ASN n 
2 32  TYR n 
2 33  TYR n 
2 34  ARG n 
2 35  ASP n 
2 36  SER n 
2 37  ALA n 
2 38  SER n 
2 39  ASN n 
2 40  ALA n 
2 41  ALA n 
2 42  SER n 
2 43  LYS n 
2 44  GLN n 
2 45  ASP n 
2 46  PHE n 
2 47  ALA n 
2 48  GLN n 
2 49  ASP n 
2 50  PRO n 
2 51  SER n 
2 52  LYS n 
2 53  PHE n 
2 54  THR n 
2 55  GLU n 
2 56  PRO n 
2 57  VAL n 
2 58  LYS n 
2 59  ASP n 
2 60  VAL n 
2 61  LEU n 
2 62  ILE n 
2 63  LYS n 
2 64  THR n 
2 65  ALA n 
2 66  PRO n 
2 67  THR n 
2 68  LEU n 
2 69  ASN n 
2 70  SER n 
2 71  PRO n 
2 72  ASN n 
2 73  ILE n 
2 74  GLU n 
2 75  ALA n 
2 76  CYS n 
2 77  GLY n 
2 78  TYR n 
2 79  SER n 
2 80  ASP n 
2 81  ARG n 
2 82  VAL n 
2 83  MET n 
2 84  GLN n 
2 85  LEU n 
2 86  THR n 
2 87  LEU n 
2 88  GLY n 
2 89  ASN n 
2 90  SER n 
2 91  THR n 
2 92  ILE n 
2 93  THR n 
2 94  THR n 
2 95  GLN n 
2 96  GLU n 
2 97  ALA n 
2 98  ALA n 
2 99  ASN n 
2 100 SER n 
2 101 VAL n 
2 102 VAL n 
2 103 ALA n 
2 104 TYR n 
2 105 GLY n 
2 106 ARG n 
2 107 TRP n 
2 108 PRO n 
2 109 GLU n 
2 110 TYR n 
2 111 ILE n 
2 112 LYS n 
2 113 ASP n 
2 114 SER n 
2 115 GLU n 
2 116 ALA n 
2 117 ASN n 
2 118 PRO n 
2 119 VAL n 
2 120 ASP n 
2 121 GLN n 
2 122 PRO n 
2 123 THR n 
2 124 GLU n 
2 125 PRO n 
2 126 ALA n 
2 127 VAL n 
2 128 ALA n 
2 129 ALA n 
2 130 CYS n 
2 131 ARG n 
2 132 PHE n 
2 133 TYR n 
2 134 THR n 
2 135 LEU n 
2 136 ASP n 
2 137 THR n 
2 138 VAL n 
2 139 THR n 
2 140 TRP n 
2 141 ARG n 
2 142 LYS n 
2 143 GLU n 
2 144 SER n 
2 145 ARG n 
2 146 GLY n 
2 147 TRP n 
2 148 TRP n 
2 149 TRP n 
2 150 LYS n 
2 151 LEU n 
2 152 PRO n 
2 153 ASP n 
2 154 ALA n 
2 155 LEU n 
2 156 LYS n 
2 157 ASP n 
2 158 MET n 
2 159 GLY n 
2 160 LEU n 
2 161 PHE n 
2 162 GLY n 
2 163 GLN n 
2 164 ASN n 
2 165 MET n 
2 166 PHE n 
2 167 TYR n 
2 168 HIS n 
2 169 TYR n 
2 170 LEU n 
2 171 GLY n 
2 172 ARG n 
2 173 ALA n 
2 174 GLY n 
2 175 TYR n 
2 176 THR n 
2 177 VAL n 
2 178 HIS n 
2 179 VAL n 
2 180 GLN n 
2 181 CYS n 
2 182 ASN n 
2 183 ALA n 
2 184 SER n 
2 185 LYS n 
2 186 PHE n 
2 187 HIS n 
2 188 GLN n 
2 189 GLY n 
2 190 ALA n 
2 191 LEU n 
2 192 GLY n 
2 193 VAL n 
2 194 PHE n 
2 195 ALA n 
2 196 VAL n 
2 197 PRO n 
2 198 GLU n 
2 199 MET n 
2 200 CYS n 
2 201 LEU n 
2 202 ALA n 
2 203 GLY n 
2 204 ASP n 
2 205 SER n 
2 206 THR n 
2 207 THR n 
2 208 HIS n 
2 209 MET n 
2 210 PHE n 
2 211 THR n 
2 212 LYS n 
2 213 TYR n 
2 214 GLU n 
2 215 ASN n 
2 216 ALA n 
2 217 ASN n 
2 218 PRO n 
2 219 GLY n 
2 220 GLU n 
2 221 LYS n 
2 222 GLY n 
2 223 GLY n 
2 224 GLU n 
2 225 PHE n 
2 226 LYS n 
2 227 GLY n 
2 228 SER n 
2 229 PHE n 
2 230 THR n 
2 231 LEU n 
2 232 ASP n 
2 233 THR n 
2 234 ASN n 
2 235 ALA n 
2 236 THR n 
2 237 ASN n 
2 238 PRO n 
2 239 ALA n 
2 240 ARG n 
2 241 ASN n 
2 242 PHE n 
2 243 CYS n 
2 244 PRO n 
2 245 VAL n 
2 246 ASP n 
2 247 TYR n 
2 248 LEU n 
2 249 PHE n 
2 250 GLY n 
2 251 SER n 
2 252 GLY n 
2 253 VAL n 
2 254 LEU n 
2 255 ALA n 
2 256 GLY n 
2 257 ASN n 
2 258 ALA n 
2 259 PHE n 
2 260 VAL n 
2 261 TYR n 
2 262 PRO n 
2 263 HIS n 
2 264 GLN n 
2 265 ILE n 
2 266 ILE n 
2 267 ASN n 
2 268 LEU n 
2 269 ARG n 
2 270 THR n 
2 271 ASN n 
2 272 ASN n 
2 273 CYS n 
2 274 ALA n 
2 275 THR n 
2 276 LEU n 
2 277 VAL n 
2 278 LEU n 
2 279 PRO n 
2 280 TYR n 
2 281 VAL n 
2 282 ASN n 
2 283 SER n 
2 284 LEU n 
2 285 SER n 
2 286 ILE n 
2 287 ASP n 
2 288 SER n 
2 289 MET n 
2 290 THR n 
2 291 LYS n 
2 292 HIS n 
2 293 ASN n 
2 294 ASN n 
2 295 TRP n 
2 296 GLY n 
2 297 ILE n 
2 298 ALA n 
2 299 ILE n 
2 300 LEU n 
2 301 PRO n 
2 302 LEU n 
2 303 ALA n 
2 304 PRO n 
2 305 LEU n 
2 306 ASP n 
2 307 PHE n 
2 308 ALA n 
2 309 THR n 
2 310 GLU n 
2 311 SER n 
2 312 SER n 
2 313 THR n 
2 314 GLU n 
2 315 ILE n 
2 316 PRO n 
2 317 ILE n 
2 318 THR n 
2 319 LEU n 
2 320 THR n 
2 321 ILE n 
2 322 ALA n 
2 323 PRO n 
2 324 MET n 
2 325 CYS n 
2 326 CYS n 
2 327 GLU n 
2 328 PHE n 
2 329 ASN n 
2 330 GLY n 
2 331 LEU n 
2 332 ARG n 
2 333 ASN n 
2 334 ILE n 
2 335 THR n 
2 336 VAL n 
2 337 PRO n 
2 338 ARG n 
2 339 THR n 
2 340 GLN n 
3 1   GLY n 
3 2   LEU n 
3 3   PRO n 
3 4   VAL n 
3 5   LEU n 
3 6   ASN n 
3 7   THR n 
3 8   PRO n 
3 9   GLY n 
3 10  SER n 
3 11  ASN n 
3 12  GLN n 
3 13  TYR n 
3 14  LEU n 
3 15  THR n 
3 16  ALA n 
3 17  ASP n 
3 18  ASN n 
3 19  TYR n 
3 20  GLN n 
3 21  SER n 
3 22  PRO n 
3 23  CYS n 
3 24  ALA n 
3 25  ILE n 
3 26  PRO n 
3 27  GLU n 
3 28  PHE n 
3 29  ASP n 
3 30  VAL n 
3 31  THR n 
3 32  PRO n 
3 33  PRO n 
3 34  ILE n 
3 35  ASP n 
3 36  ILE n 
3 37  PRO n 
3 38  GLY n 
3 39  GLU n 
3 40  VAL n 
3 41  ARG n 
3 42  ASN n 
3 43  MET n 
3 44  MET n 
3 45  GLU n 
3 46  LEU n 
3 47  ALA n 
3 48  GLU n 
3 49  ILE n 
3 50  ASP n 
3 51  THR n 
3 52  MET n 
3 53  ILE n 
3 54  PRO n 
3 55  LEU n 
3 56  ASN n 
3 57  LEU n 
3 58  THR n 
3 59  ASN n 
3 60  GLN n 
3 61  ARG n 
3 62  LYS n 
3 63  ASN n 
3 64  THR n 
3 65  MET n 
3 66  ASP n 
3 67  MET n 
3 68  TYR n 
3 69  ARG n 
3 70  VAL n 
3 71  GLU n 
3 72  LEU n 
3 73  ASN n 
3 74  ASP n 
3 75  ALA n 
3 76  ALA n 
3 77  HIS n 
3 78  SER n 
3 79  ASP n 
3 80  THR n 
3 81  PRO n 
3 82  ILE n 
3 83  LEU n 
3 84  CYS n 
3 85  LEU n 
3 86  SER n 
3 87  LEU n 
3 88  SER n 
3 89  PRO n 
3 90  ALA n 
3 91  SER n 
3 92  ASP n 
3 93  PRO n 
3 94  ARG n 
3 95  LEU n 
3 96  ALA n 
3 97  HIS n 
3 98  THR n 
3 99  MET n 
3 100 LEU n 
3 101 GLY n 
3 102 GLU n 
3 103 ILE n 
3 104 LEU n 
3 105 ASN n 
3 106 TYR n 
3 107 TYR n 
3 108 THR n 
3 109 HIS n 
3 110 TRP n 
3 111 ALA n 
3 112 GLY n 
3 113 SER n 
3 114 LEU n 
3 115 LYS n 
3 116 PHE n 
3 117 THR n 
3 118 PHE n 
3 119 LEU n 
3 120 PHE n 
3 121 CYS n 
3 122 GLY n 
3 123 SER n 
3 124 MET n 
3 125 MET n 
3 126 ALA n 
3 127 THR n 
3 128 GLY n 
3 129 LYS n 
3 130 LEU n 
3 131 LEU n 
3 132 VAL n 
3 133 SER n 
3 134 TYR n 
3 135 ALA n 
3 136 PRO n 
3 137 PRO n 
3 138 GLY n 
3 139 ALA n 
3 140 GLU n 
3 141 ALA n 
3 142 PRO n 
3 143 LYS n 
3 144 SER n 
3 145 ARG n 
3 146 LYS n 
3 147 GLU n 
3 148 ALA n 
3 149 MET n 
3 150 LEU n 
3 151 GLY n 
3 152 THR n 
3 153 HIS n 
3 154 VAL n 
3 155 ILE n 
3 156 TRP n 
3 157 ASP n 
3 158 ILE n 
3 159 GLY n 
3 160 LEU n 
3 161 GLN n 
3 162 SER n 
3 163 SER n 
3 164 CYS n 
3 165 THR n 
3 166 MET n 
3 167 VAL n 
3 168 VAL n 
3 169 PRO n 
3 170 TRP n 
3 171 ILE n 
3 172 SER n 
3 173 ASN n 
3 174 THR n 
3 175 THR n 
3 176 TYR n 
3 177 ARG n 
3 178 LEU n 
3 179 THR n 
3 180 ILE n 
3 181 ASN n 
3 182 ASP n 
3 183 SER n 
3 184 PHE n 
3 185 THR n 
3 186 GLU n 
3 187 GLY n 
3 188 GLY n 
3 189 TYR n 
3 190 ILE n 
3 191 SER n 
3 192 MET n 
3 193 PHE n 
3 194 TYR n 
3 195 GLN n 
3 196 THR n 
3 197 ARG n 
3 198 VAL n 
3 199 VAL n 
3 200 VAL n 
3 201 PRO n 
3 202 LEU n 
3 203 SER n 
3 204 THR n 
3 205 PRO n 
3 206 ARG n 
3 207 LYS n 
3 208 MET n 
3 209 ASP n 
3 210 ILE n 
3 211 LEU n 
3 212 GLY n 
3 213 PHE n 
3 214 VAL n 
3 215 SER n 
3 216 ALA n 
3 217 CYS n 
3 218 ASN n 
3 219 ASP n 
3 220 PHE n 
3 221 SER n 
3 222 VAL n 
3 223 ARG n 
3 224 LEU n 
3 225 LEU n 
3 226 ARG n 
3 227 ASP n 
3 228 THR n 
3 229 THR n 
3 230 HIS n 
3 231 ILE n 
3 232 SER n 
3 233 GLN n 
3 234 GLU n 
3 235 ALA n 
3 236 MET n 
3 237 PRO n 
3 238 GLN n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 301 ? ? ? ? MEF-1 ? ? ? ? 'Poliovirus 2' 12083 ? ? ? ? ? ? ? ? 'Komagataella pastoris' 4922 ? ? 
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 340 ? ? ? ? MEF-1 ? ? ? ? 'Poliovirus 2' 12083 ? ? ? ? ? ? ? ? 'Komagataella pastoris' 4922 ? ? 
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
3 1 sample 'Biological sequence' 1 238 ? ? ? ? MEF-1 ? ? ? ? 'Poliovirus 2' 12083 ? ? ? ? ? ? ? ? 'Komagataella pastoris' 4922 ? ? 
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
SPH non-polymer         . SPHINGOSINE     ? 'C18 H37 N O2'   299.492 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   1   ?   ?   ?   A . n 
A 1 2   LEU 2   2   ?   ?   ?   A . n 
A 1 3   GLY 3   3   ?   ?   ?   A . n 
A 1 4   ASP 4   4   ?   ?   ?   A . n 
A 1 5   LEU 5   5   ?   ?   ?   A . n 
A 1 6   ILE 6   6   ?   ?   ?   A . n 
A 1 7   GLU 7   7   ?   ?   ?   A . n 
A 1 8   GLY 8   8   ?   ?   ?   A . n 
A 1 9   VAL 9   9   ?   ?   ?   A . n 
A 1 10  VAL 10  10  ?   ?   ?   A . n 
A 1 11  GLU 11  11  ?   ?   ?   A . n 
A 1 12  GLY 12  12  ?   ?   ?   A . n 
A 1 13  VAL 13  13  ?   ?   ?   A . n 
A 1 14  THR 14  14  ?   ?   ?   A . n 
A 1 15  ARG 15  15  ?   ?   ?   A . n 
A 1 16  ASN 16  16  ?   ?   ?   A . n 
A 1 17  ALA 17  17  ?   ?   ?   A . n 
A 1 18  LEU 18  18  ?   ?   ?   A . n 
A 1 19  THR 19  19  ?   ?   ?   A . n 
A 1 20  PRO 20  20  ?   ?   ?   A . n 
A 1 21  LEU 21  21  ?   ?   ?   A . n 
A 1 22  THR 22  22  ?   ?   ?   A . n 
A 1 23  PRO 23  23  ?   ?   ?   A . n 
A 1 24  ALA 24  24  ?   ?   ?   A . n 
A 1 25  ASN 25  25  ?   ?   ?   A . n 
A 1 26  ASN 26  26  ?   ?   ?   A . n 
A 1 27  LEU 27  27  ?   ?   ?   A . n 
A 1 28  PRO 28  28  ?   ?   ?   A . n 
A 1 29  ASP 29  29  ?   ?   ?   A . n 
A 1 30  THR 30  30  ?   ?   ?   A . n 
A 1 31  GLN 31  31  ?   ?   ?   A . n 
A 1 32  SER 32  32  ?   ?   ?   A . n 
A 1 33  SER 33  33  ?   ?   ?   A . n 
A 1 34  GLY 34  34  ?   ?   ?   A . n 
A 1 35  PRO 35  35  ?   ?   ?   A . n 
A 1 36  ALA 36  36  ?   ?   ?   A . n 
A 1 37  HIS 37  37  ?   ?   ?   A . n 
A 1 38  SER 38  38  ?   ?   ?   A . n 
A 1 39  LYS 39  39  ?   ?   ?   A . n 
A 1 40  GLU 40  40  ?   ?   ?   A . n 
A 1 41  THR 41  41  ?   ?   ?   A . n 
A 1 42  PRO 42  42  ?   ?   ?   A . n 
A 1 43  ALA 43  43  ?   ?   ?   A . n 
A 1 44  LEU 44  44  ?   ?   ?   A . n 
A 1 45  THR 45  45  ?   ?   ?   A . n 
A 1 46  ALA 46  46  ?   ?   ?   A . n 
A 1 47  VAL 47  47  ?   ?   ?   A . n 
A 1 48  GLU 48  48  ?   ?   ?   A . n 
A 1 49  THR 49  49  ?   ?   ?   A . n 
A 1 50  GLY 50  50  ?   ?   ?   A . n 
A 1 51  ALA 51  51  ?   ?   ?   A . n 
A 1 52  THR 52  52  ?   ?   ?   A . n 
A 1 53  ASN 53  53  ?   ?   ?   A . n 
A 1 54  PRO 54  54  ?   ?   ?   A . n 
A 1 55  LEU 55  55  ?   ?   ?   A . n 
A 1 56  VAL 56  56  ?   ?   ?   A . n 
A 1 57  PRO 57  57  ?   ?   ?   A . n 
A 1 58  SER 58  58  ?   ?   ?   A . n 
A 1 59  ASP 59  59  ?   ?   ?   A . n 
A 1 60  THR 60  60  ?   ?   ?   A . n 
A 1 61  VAL 61  61  ?   ?   ?   A . n 
A 1 62  GLN 62  62  ?   ?   ?   A . n 
A 1 63  THR 63  63  ?   ?   ?   A . n 
A 1 64  ARG 64  64  ?   ?   ?   A . n 
A 1 65  HIS 65  65  ?   ?   ?   A . n 
A 1 66  VAL 66  66  ?   ?   ?   A . n 
A 1 67  ILE 67  67  ?   ?   ?   A . n 
A 1 68  GLN 68  68  ?   ?   ?   A . n 
A 1 69  LYS 69  69  ?   ?   ?   A . n 
A 1 70  ARG 70  70  70  ARG ARG A . n 
A 1 71  THR 71  71  71  THR THR A . n 
A 1 72  ARG 72  72  72  ARG ARG A . n 
A 1 73  SER 73  73  73  SER SER A . n 
A 1 74  GLU 74  74  74  GLU GLU A . n 
A 1 75  SER 75  75  75  SER SER A . n 
A 1 76  THR 76  76  76  THR THR A . n 
A 1 77  VAL 77  77  77  VAL VAL A . n 
A 1 78  GLU 78  78  78  GLU GLU A . n 
A 1 79  SER 79  79  79  SER SER A . n 
A 1 80  PHE 80  80  80  PHE PHE A . n 
A 1 81  PHE 81  81  81  PHE PHE A . n 
A 1 82  ALA 82  82  82  ALA ALA A . n 
A 1 83  ARG 83  83  83  ARG ARG A . n 
A 1 84  GLY 84  84  84  GLY GLY A . n 
A 1 85  ALA 85  85  85  ALA ALA A . n 
A 1 86  CYS 86  86  86  CYS CYS A . n 
A 1 87  VAL 87  87  87  VAL VAL A . n 
A 1 88  ALA 88  88  88  ALA ALA A . n 
A 1 89  ILE 89  89  89  ILE ILE A . n 
A 1 90  ILE 90  90  90  ILE ILE A . n 
A 1 91  GLU 91  91  91  GLU GLU A . n 
A 1 92  VAL 92  92  92  VAL VAL A . n 
A 1 93  ASP 93  93  93  ASP ASP A . n 
A 1 94  ASN 94  94  94  ASN ASN A . n 
A 1 95  ASP 95  95  95  ASP ASP A . n 
A 1 96  ALA 96  96  96  ALA ALA A . n 
A 1 97  PRO 97  97  97  PRO PRO A . n 
A 1 98  THR 98  98  ?   ?   ?   A . n 
A 1 99  LYS 99  99  ?   ?   ?   A . n 
A 1 100 ARG 100 100 ?   ?   ?   A . n 
A 1 101 ALA 101 101 101 ALA ALA A . n 
A 1 102 SER 102 102 102 SER SER A . n 
A 1 103 LYS 103 103 103 LYS LYS A . n 
A 1 104 LEU 104 104 104 LEU LEU A . n 
A 1 105 PHE 105 105 105 PHE PHE A . n 
A 1 106 SER 106 106 106 SER SER A . n 
A 1 107 ILE 107 107 107 ILE ILE A . n 
A 1 108 TRP 108 108 108 TRP TRP A . n 
A 1 109 LYS 109 109 109 LYS LYS A . n 
A 1 110 ILE 110 110 110 ILE ILE A . n 
A 1 111 THR 111 111 111 THR THR A . n 
A 1 112 TYR 112 112 112 TYR TYR A . n 
A 1 113 LYS 113 113 113 LYS LYS A . n 
A 1 114 ASP 114 114 114 ASP ASP A . n 
A 1 115 THR 115 115 115 THR THR A . n 
A 1 116 VAL 116 116 116 VAL VAL A . n 
A 1 117 GLN 117 117 117 GLN GLN A . n 
A 1 118 LEU 118 118 118 LEU LEU A . n 
A 1 119 ARG 119 119 119 ARG ARG A . n 
A 1 120 ARG 120 120 120 ARG ARG A . n 
A 1 121 LYS 121 121 121 LYS LYS A . n 
A 1 122 LEU 122 122 122 LEU LEU A . n 
A 1 123 GLU 123 123 123 GLU GLU A . n 
A 1 124 PHE 124 124 124 PHE PHE A . n 
A 1 125 PHE 125 125 125 PHE PHE A . n 
A 1 126 THR 126 126 126 THR THR A . n 
A 1 127 TYR 127 127 127 TYR TYR A . n 
A 1 128 SER 128 128 128 SER SER A . n 
A 1 129 ARG 129 129 129 ARG ARG A . n 
A 1 130 PHE 130 130 130 PHE PHE A . n 
A 1 131 ASP 131 131 131 ASP ASP A . n 
A 1 132 MET 132 132 132 MET MET A . n 
A 1 133 GLU 133 133 133 GLU GLU A . n 
A 1 134 LEU 134 134 134 LEU LEU A . n 
A 1 135 THR 135 135 135 THR THR A . n 
A 1 136 PHE 136 136 136 PHE PHE A . n 
A 1 137 VAL 137 137 137 VAL VAL A . n 
A 1 138 VAL 138 138 138 VAL VAL A . n 
A 1 139 THR 139 139 139 THR THR A . n 
A 1 140 SER 140 140 140 SER SER A . n 
A 1 141 ASN 141 141 141 ASN ASN A . n 
A 1 142 TYR 142 142 142 TYR TYR A . n 
A 1 143 THR 143 143 143 THR THR A . n 
A 1 144 ASP 144 144 144 ASP ASP A . n 
A 1 145 ALA 145 145 145 ALA ALA A . n 
A 1 146 ASN 146 146 146 ASN ASN A . n 
A 1 147 ASN 147 147 147 ASN ASN A . n 
A 1 148 GLY 148 148 148 GLY GLY A . n 
A 1 149 HIS 149 149 149 HIS HIS A . n 
A 1 150 ALA 150 150 150 ALA ALA A . n 
A 1 151 LEU 151 151 151 LEU LEU A . n 
A 1 152 ASN 152 152 152 ASN ASN A . n 
A 1 153 GLN 153 153 153 GLN GLN A . n 
A 1 154 VAL 154 154 154 VAL VAL A . n 
A 1 155 TYR 155 155 155 TYR TYR A . n 
A 1 156 GLN 156 156 156 GLN GLN A . n 
A 1 157 ILE 157 157 157 ILE ILE A . n 
A 1 158 MET 158 158 158 MET MET A . n 
A 1 159 TYR 159 159 159 TYR TYR A . n 
A 1 160 ILE 160 160 160 ILE ILE A . n 
A 1 161 PRO 161 161 161 PRO PRO A . n 
A 1 162 PRO 162 162 162 PRO PRO A . n 
A 1 163 GLY 163 163 163 GLY GLY A . n 
A 1 164 ALA 164 164 164 ALA ALA A . n 
A 1 165 PRO 165 165 165 PRO PRO A . n 
A 1 166 ILE 166 166 166 ILE ILE A . n 
A 1 167 PRO 167 167 167 PRO PRO A . n 
A 1 168 GLY 168 168 168 GLY GLY A . n 
A 1 169 LYS 169 169 169 LYS LYS A . n 
A 1 170 TRP 170 170 170 TRP TRP A . n 
A 1 171 ASN 171 171 171 ASN ASN A . n 
A 1 172 ASP 172 172 172 ASP ASP A . n 
A 1 173 TYR 173 173 173 TYR TYR A . n 
A 1 174 THR 174 174 174 THR THR A . n 
A 1 175 TRP 175 175 175 TRP TRP A . n 
A 1 176 GLN 176 176 176 GLN GLN A . n 
A 1 177 THR 177 177 177 THR THR A . n 
A 1 178 SER 178 178 178 SER SER A . n 
A 1 179 SER 179 179 179 SER SER A . n 
A 1 180 ASN 180 180 180 ASN ASN A . n 
A 1 181 PRO 181 181 181 PRO PRO A . n 
A 1 182 SER 182 182 182 SER SER A . n 
A 1 183 LEU 183 183 183 LEU LEU A . n 
A 1 184 PHE 184 184 184 PHE PHE A . n 
A 1 185 TYR 185 185 185 TYR TYR A . n 
A 1 186 THR 186 186 186 THR THR A . n 
A 1 187 TYR 187 187 187 TYR TYR A . n 
A 1 188 GLY 188 188 188 GLY GLY A . n 
A 1 189 ALA 189 189 189 ALA ALA A . n 
A 1 190 PRO 190 190 190 PRO PRO A . n 
A 1 191 PRO 191 191 191 PRO PRO A . n 
A 1 192 ALA 192 192 192 ALA ALA A . n 
A 1 193 ARG 193 193 193 ARG ARG A . n 
A 1 194 ILE 194 194 194 ILE ILE A . n 
A 1 195 SER 195 195 195 SER SER A . n 
A 1 196 VAL 196 196 196 VAL VAL A . n 
A 1 197 PRO 197 197 197 PRO PRO A . n 
A 1 198 TYR 198 198 198 TYR TYR A . n 
A 1 199 VAL 199 199 199 VAL VAL A . n 
A 1 200 GLY 200 200 200 GLY GLY A . n 
A 1 201 ILE 201 201 201 ILE ILE A . n 
A 1 202 ALA 202 202 202 ALA ALA A . n 
A 1 203 ASN 203 203 203 ASN ASN A . n 
A 1 204 ALA 204 204 204 ALA ALA A . n 
A 1 205 TYR 205 205 205 TYR TYR A . n 
A 1 206 SER 206 206 206 SER SER A . n 
A 1 207 HIS 207 207 207 HIS HIS A . n 
A 1 208 PHE 208 208 208 PHE PHE A . n 
A 1 209 TYR 209 209 209 TYR TYR A . n 
A 1 210 ASP 210 210 210 ASP ASP A . n 
A 1 211 GLY 211 211 211 GLY GLY A . n 
A 1 212 PHE 212 212 212 PHE PHE A . n 
A 1 213 ALA 213 213 213 ALA ALA A . n 
A 1 214 LYS 214 214 214 LYS LYS A . n 
A 1 215 VAL 215 215 215 VAL VAL A . n 
A 1 216 PRO 216 216 216 PRO PRO A . n 
A 1 217 LEU 217 217 217 LEU LEU A . n 
A 1 218 ALA 218 218 218 ALA ALA A . n 
A 1 219 GLY 219 219 219 GLY GLY A . n 
A 1 220 GLN 220 220 220 GLN GLN A . n 
A 1 221 ALA 221 221 221 ALA ALA A . n 
A 1 222 SER 222 222 222 SER SER A . n 
A 1 223 THR 223 223 ?   ?   ?   A . n 
A 1 224 GLU 224 224 ?   ?   ?   A . n 
A 1 225 GLY 225 225 225 GLY GLY A . n 
A 1 226 ASP 226 226 226 ASP ASP A . n 
A 1 227 SER 227 227 227 SER SER A . n 
A 1 228 LEU 228 228 228 LEU LEU A . n 
A 1 229 TYR 229 229 229 TYR TYR A . n 
A 1 230 GLY 230 230 230 GLY GLY A . n 
A 1 231 ALA 231 231 231 ALA ALA A . n 
A 1 232 ALA 232 232 232 ALA ALA A . n 
A 1 233 SER 233 233 233 SER SER A . n 
A 1 234 LEU 234 234 234 LEU LEU A . n 
A 1 235 ASN 235 235 235 ASN ASN A . n 
A 1 236 ASP 236 236 236 ASP ASP A . n 
A 1 237 PHE 237 237 237 PHE PHE A . n 
A 1 238 GLY 238 238 238 GLY GLY A . n 
A 1 239 SER 239 239 239 SER SER A . n 
A 1 240 LEU 240 240 240 LEU LEU A . n 
A 1 241 ALA 241 241 241 ALA ALA A . n 
A 1 242 VAL 242 242 242 VAL VAL A . n 
A 1 243 ARG 243 243 243 ARG ARG A . n 
A 1 244 VAL 244 244 244 VAL VAL A . n 
A 1 245 VAL 245 245 245 VAL VAL A . n 
A 1 246 ASN 246 246 246 ASN ASN A . n 
A 1 247 ASP 247 247 247 ASP ASP A . n 
A 1 248 HIS 248 248 248 HIS HIS A . n 
A 1 249 ASN 249 249 249 ASN ASN A . n 
A 1 250 PRO 250 250 250 PRO PRO A . n 
A 1 251 THR 251 251 251 THR THR A . n 
A 1 252 LYS 252 252 252 LYS LYS A . n 
A 1 253 LEU 253 253 253 LEU LEU A . n 
A 1 254 THR 254 254 254 THR THR A . n 
A 1 255 SER 255 255 255 SER SER A . n 
A 1 256 LYS 256 256 256 LYS LYS A . n 
A 1 257 ILE 257 257 257 ILE ILE A . n 
A 1 258 ARG 258 258 258 ARG ARG A . n 
A 1 259 VAL 259 259 259 VAL VAL A . n 
A 1 260 TYR 260 260 260 TYR TYR A . n 
A 1 261 MET 261 261 261 MET MET A . n 
A 1 262 LYS 262 262 262 LYS LYS A . n 
A 1 263 PRO 263 263 263 PRO PRO A . n 
A 1 264 LYS 264 264 264 LYS LYS A . n 
A 1 265 HIS 265 265 265 HIS HIS A . n 
A 1 266 VAL 266 266 266 VAL VAL A . n 
A 1 267 ARG 267 267 267 ARG ARG A . n 
A 1 268 VAL 268 268 268 VAL VAL A . n 
A 1 269 TRP 269 269 269 TRP TRP A . n 
A 1 270 CYS 270 270 270 CYS CYS A . n 
A 1 271 PRO 271 271 271 PRO PRO A . n 
A 1 272 ARG 272 272 272 ARG ARG A . n 
A 1 273 PRO 273 273 273 PRO PRO A . n 
A 1 274 PRO 274 274 274 PRO PRO A . n 
A 1 275 ARG 275 275 275 ARG ARG A . n 
A 1 276 ALA 276 276 276 ALA ALA A . n 
A 1 277 VAL 277 277 277 VAL VAL A . n 
A 1 278 PRO 278 278 278 PRO PRO A . n 
A 1 279 TYR 279 279 279 TYR TYR A . n 
A 1 280 TYR 280 280 280 TYR TYR A . n 
A 1 281 GLY 281 281 281 GLY GLY A . n 
A 1 282 PRO 282 282 282 PRO PRO A . n 
A 1 283 GLY 283 283 283 GLY GLY A . n 
A 1 284 VAL 284 284 284 VAL VAL A . n 
A 1 285 ASP 285 285 285 ASP ASP A . n 
A 1 286 TYR 286 286 286 TYR TYR A . n 
A 1 287 LYS 287 287 287 LYS LYS A . n 
A 1 288 ASP 288 288 288 ASP ASP A . n 
A 1 289 GLY 289 289 289 GLY GLY A . n 
A 1 290 LEU 290 290 290 LEU LEU A . n 
A 1 291 ALA 291 291 291 ALA ALA A . n 
A 1 292 PRO 292 292 292 PRO PRO A . n 
A 1 293 LEU 293 293 293 LEU LEU A . n 
A 1 294 PRO 294 294 294 PRO PRO A . n 
A 1 295 GLU 295 295 295 GLU GLU A . n 
A 1 296 LYS 296 296 296 LYS LYS A . n 
A 1 297 GLY 297 297 297 GLY GLY A . n 
A 1 298 LEU 298 298 298 LEU LEU A . n 
A 1 299 THR 299 299 299 THR THR A . n 
A 1 300 THR 300 300 300 THR THR A . n 
A 1 301 TYR 301 301 301 TYR TYR A . n 
B 2 1   MET 1   1   ?   ?   ?   B . n 
B 2 2   GLY 2   2   ?   ?   ?   B . n 
B 2 3   ALA 3   3   ?   ?   ?   B . n 
B 2 4   GLN 4   4   ?   ?   ?   B . n 
B 2 5   VAL 5   5   ?   ?   ?   B . n 
B 2 6   SER 6   6   ?   ?   ?   B . n 
B 2 7   SER 7   7   ?   ?   ?   B . n 
B 2 8   GLN 8   8   ?   ?   ?   B . n 
B 2 9   LYS 9   9   ?   ?   ?   B . n 
B 2 10  VAL 10  10  ?   ?   ?   B . n 
B 2 11  GLY 11  11  ?   ?   ?   B . n 
B 2 12  ALA 12  12  ?   ?   ?   B . n 
B 2 13  HIS 13  13  ?   ?   ?   B . n 
B 2 14  GLU 14  14  ?   ?   ?   B . n 
B 2 15  ASN 15  15  ?   ?   ?   B . n 
B 2 16  SER 16  16  ?   ?   ?   B . n 
B 2 17  ASN 17  17  ?   ?   ?   B . n 
B 2 18  ARG 18  18  ?   ?   ?   B . n 
B 2 19  ALA 19  19  ?   ?   ?   B . n 
B 2 20  TYR 20  20  ?   ?   ?   B . n 
B 2 21  GLY 21  21  ?   ?   ?   B . n 
B 2 22  GLY 22  22  ?   ?   ?   B . n 
B 2 23  SER 23  23  ?   ?   ?   B . n 
B 2 24  THR 24  24  ?   ?   ?   B . n 
B 2 25  ILE 25  25  ?   ?   ?   B . n 
B 2 26  ASN 26  26  ?   ?   ?   B . n 
B 2 27  TYR 27  27  ?   ?   ?   B . n 
B 2 28  THR 28  28  ?   ?   ?   B . n 
B 2 29  THR 29  29  ?   ?   ?   B . n 
B 2 30  ILE 30  30  ?   ?   ?   B . n 
B 2 31  ASN 31  31  ?   ?   ?   B . n 
B 2 32  TYR 32  32  ?   ?   ?   B . n 
B 2 33  TYR 33  33  ?   ?   ?   B . n 
B 2 34  ARG 34  34  ?   ?   ?   B . n 
B 2 35  ASP 35  35  ?   ?   ?   B . n 
B 2 36  SER 36  36  ?   ?   ?   B . n 
B 2 37  ALA 37  37  ?   ?   ?   B . n 
B 2 38  SER 38  38  ?   ?   ?   B . n 
B 2 39  ASN 39  39  ?   ?   ?   B . n 
B 2 40  ALA 40  40  ?   ?   ?   B . n 
B 2 41  ALA 41  41  ?   ?   ?   B . n 
B 2 42  SER 42  42  ?   ?   ?   B . n 
B 2 43  LYS 43  43  ?   ?   ?   B . n 
B 2 44  GLN 44  44  ?   ?   ?   B . n 
B 2 45  ASP 45  45  ?   ?   ?   B . n 
B 2 46  PHE 46  46  ?   ?   ?   B . n 
B 2 47  ALA 47  47  ?   ?   ?   B . n 
B 2 48  GLN 48  48  ?   ?   ?   B . n 
B 2 49  ASP 49  49  ?   ?   ?   B . n 
B 2 50  PRO 50  50  ?   ?   ?   B . n 
B 2 51  SER 51  51  ?   ?   ?   B . n 
B 2 52  LYS 52  52  ?   ?   ?   B . n 
B 2 53  PHE 53  53  ?   ?   ?   B . n 
B 2 54  THR 54  54  ?   ?   ?   B . n 
B 2 55  GLU 55  55  ?   ?   ?   B . n 
B 2 56  PRO 56  56  ?   ?   ?   B . n 
B 2 57  VAL 57  57  ?   ?   ?   B . n 
B 2 58  LYS 58  58  ?   ?   ?   B . n 
B 2 59  ASP 59  59  ?   ?   ?   B . n 
B 2 60  VAL 60  60  ?   ?   ?   B . n 
B 2 61  LEU 61  61  ?   ?   ?   B . n 
B 2 62  ILE 62  62  ?   ?   ?   B . n 
B 2 63  LYS 63  63  ?   ?   ?   B . n 
B 2 64  THR 64  64  ?   ?   ?   B . n 
B 2 65  ALA 65  65  ?   ?   ?   B . n 
B 2 66  PRO 66  66  ?   ?   ?   B . n 
B 2 67  THR 67  67  ?   ?   ?   B . n 
B 2 68  LEU 68  68  ?   ?   ?   B . n 
B 2 69  ASN 69  69  ?   ?   ?   B . n 
B 2 70  SER 70  70  ?   ?   ?   B . n 
B 2 71  PRO 71  71  ?   ?   ?   B . n 
B 2 72  ASN 72  72  ?   ?   ?   B . n 
B 2 73  ILE 73  73  ?   ?   ?   B . n 
B 2 74  GLU 74  74  ?   ?   ?   B . n 
B 2 75  ALA 75  75  ?   ?   ?   B . n 
B 2 76  CYS 76  76  ?   ?   ?   B . n 
B 2 77  GLY 77  77  ?   ?   ?   B . n 
B 2 78  TYR 78  78  ?   ?   ?   B . n 
B 2 79  SER 79  79  ?   ?   ?   B . n 
B 2 80  ASP 80  80  ?   ?   ?   B . n 
B 2 81  ARG 81  81  ?   ?   ?   B . n 
B 2 82  VAL 82  82  ?   ?   ?   B . n 
B 2 83  MET 83  83  ?   ?   ?   B . n 
B 2 84  GLN 84  84  ?   ?   ?   B . n 
B 2 85  LEU 85  85  ?   ?   ?   B . n 
B 2 86  THR 86  86  86  THR THR B . n 
B 2 87  LEU 87  87  87  LEU LEU B . n 
B 2 88  GLY 88  88  88  GLY GLY B . n 
B 2 89  ASN 89  89  89  ASN ASN B . n 
B 2 90  SER 90  90  90  SER SER B . n 
B 2 91  THR 91  91  91  THR THR B . n 
B 2 92  ILE 92  92  92  ILE ILE B . n 
B 2 93  THR 93  93  ?   ?   ?   B . n 
B 2 94  THR 94  94  ?   ?   ?   B . n 
B 2 95  GLN 95  95  ?   ?   ?   B . n 
B 2 96  GLU 96  96  ?   ?   ?   B . n 
B 2 97  ALA 97  97  ?   ?   ?   B . n 
B 2 98  ALA 98  98  ?   ?   ?   B . n 
B 2 99  ASN 99  99  99  ASN ASN B . n 
B 2 100 SER 100 100 100 SER SER B . n 
B 2 101 VAL 101 101 101 VAL VAL B . n 
B 2 102 VAL 102 102 102 VAL VAL B . n 
B 2 103 ALA 103 103 103 ALA ALA B . n 
B 2 104 TYR 104 104 104 TYR TYR B . n 
B 2 105 GLY 105 105 105 GLY GLY B . n 
B 2 106 ARG 106 106 106 ARG ARG B . n 
B 2 107 TRP 107 107 107 TRP TRP B . n 
B 2 108 PRO 108 108 108 PRO PRO B . n 
B 2 109 GLU 109 109 109 GLU GLU B . n 
B 2 110 TYR 110 110 110 TYR TYR B . n 
B 2 111 ILE 111 111 111 ILE ILE B . n 
B 2 112 LYS 112 112 ?   ?   ?   B . n 
B 2 113 ASP 113 113 ?   ?   ?   B . n 
B 2 114 SER 114 114 ?   ?   ?   B . n 
B 2 115 GLU 115 115 ?   ?   ?   B . n 
B 2 116 ALA 116 116 ?   ?   ?   B . n 
B 2 117 ASN 117 117 ?   ?   ?   B . n 
B 2 118 PRO 118 118 ?   ?   ?   B . n 
B 2 119 VAL 119 119 ?   ?   ?   B . n 
B 2 120 ASP 120 120 ?   ?   ?   B . n 
B 2 121 GLN 121 121 ?   ?   ?   B . n 
B 2 122 PRO 122 122 ?   ?   ?   B . n 
B 2 123 THR 123 123 ?   ?   ?   B . n 
B 2 124 GLU 124 124 ?   ?   ?   B . n 
B 2 125 PRO 125 125 ?   ?   ?   B . n 
B 2 126 ALA 126 126 126 ALA ALA B . n 
B 2 127 VAL 127 127 127 VAL VAL B . n 
B 2 128 ALA 128 128 128 ALA ALA B . n 
B 2 129 ALA 129 129 129 ALA ALA B . n 
B 2 130 CYS 130 130 130 CYS CYS B . n 
B 2 131 ARG 131 131 131 ARG ARG B . n 
B 2 132 PHE 132 132 132 PHE PHE B . n 
B 2 133 TYR 133 133 133 TYR TYR B . n 
B 2 134 THR 134 134 134 THR THR B . n 
B 2 135 LEU 135 135 135 LEU LEU B . n 
B 2 136 ASP 136 136 136 ASP ASP B . n 
B 2 137 THR 137 137 137 THR THR B . n 
B 2 138 VAL 138 138 138 VAL VAL B . n 
B 2 139 THR 139 139 139 THR THR B . n 
B 2 140 TRP 140 140 140 TRP TRP B . n 
B 2 141 ARG 141 141 141 ARG ARG B . n 
B 2 142 LYS 142 142 142 LYS LYS B . n 
B 2 143 GLU 143 143 143 GLU GLU B . n 
B 2 144 SER 144 144 144 SER SER B . n 
B 2 145 ARG 145 145 145 ARG ARG B . n 
B 2 146 GLY 146 146 146 GLY GLY B . n 
B 2 147 TRP 147 147 147 TRP TRP B . n 
B 2 148 TRP 148 148 148 TRP TRP B . n 
B 2 149 TRP 149 149 149 TRP TRP B . n 
B 2 150 LYS 150 150 150 LYS LYS B . n 
B 2 151 LEU 151 151 151 LEU LEU B . n 
B 2 152 PRO 152 152 152 PRO PRO B . n 
B 2 153 ASP 153 153 153 ASP ASP B . n 
B 2 154 ALA 154 154 154 ALA ALA B . n 
B 2 155 LEU 155 155 155 LEU LEU B . n 
B 2 156 LYS 156 156 156 LYS LYS B . n 
B 2 157 ASP 157 157 157 ASP ASP B . n 
B 2 158 MET 158 158 158 MET MET B . n 
B 2 159 GLY 159 159 159 GLY GLY B . n 
B 2 160 LEU 160 160 160 LEU LEU B . n 
B 2 161 PHE 161 161 161 PHE PHE B . n 
B 2 162 GLY 162 162 162 GLY GLY B . n 
B 2 163 GLN 163 163 163 GLN GLN B . n 
B 2 164 ASN 164 164 164 ASN ASN B . n 
B 2 165 MET 165 165 165 MET MET B . n 
B 2 166 PHE 166 166 166 PHE PHE B . n 
B 2 167 TYR 167 167 167 TYR TYR B . n 
B 2 168 HIS 168 168 168 HIS HIS B . n 
B 2 169 TYR 169 169 169 TYR TYR B . n 
B 2 170 LEU 170 170 170 LEU LEU B . n 
B 2 171 GLY 171 171 171 GLY GLY B . n 
B 2 172 ARG 172 172 172 ARG ARG B . n 
B 2 173 ALA 173 173 173 ALA ALA B . n 
B 2 174 GLY 174 174 174 GLY GLY B . n 
B 2 175 TYR 175 175 175 TYR TYR B . n 
B 2 176 THR 176 176 176 THR THR B . n 
B 2 177 VAL 177 177 177 VAL VAL B . n 
B 2 178 HIS 178 178 178 HIS HIS B . n 
B 2 179 VAL 179 179 179 VAL VAL B . n 
B 2 180 GLN 180 180 180 GLN GLN B . n 
B 2 181 CYS 181 181 181 CYS CYS B . n 
B 2 182 ASN 182 182 182 ASN ASN B . n 
B 2 183 ALA 183 183 183 ALA ALA B . n 
B 2 184 SER 184 184 184 SER SER B . n 
B 2 185 LYS 185 185 185 LYS LYS B . n 
B 2 186 PHE 186 186 186 PHE PHE B . n 
B 2 187 HIS 187 187 187 HIS HIS B . n 
B 2 188 GLN 188 188 188 GLN GLN B . n 
B 2 189 GLY 189 189 189 GLY GLY B . n 
B 2 190 ALA 190 190 190 ALA ALA B . n 
B 2 191 LEU 191 191 191 LEU LEU B . n 
B 2 192 GLY 192 192 192 GLY GLY B . n 
B 2 193 VAL 193 193 193 VAL VAL B . n 
B 2 194 PHE 194 194 194 PHE PHE B . n 
B 2 195 ALA 195 195 195 ALA ALA B . n 
B 2 196 VAL 196 196 196 VAL VAL B . n 
B 2 197 PRO 197 197 197 PRO PRO B . n 
B 2 198 GLU 198 198 198 GLU GLU B . n 
B 2 199 MET 199 199 199 MET MET B . n 
B 2 200 CYS 200 200 200 CYS CYS B . n 
B 2 201 LEU 201 201 201 LEU LEU B . n 
B 2 202 ALA 202 202 202 ALA ALA B . n 
B 2 203 GLY 203 203 203 GLY GLY B . n 
B 2 204 ASP 204 204 204 ASP ASP B . n 
B 2 205 SER 205 205 205 SER SER B . n 
B 2 206 THR 206 206 206 THR THR B . n 
B 2 207 THR 207 207 207 THR THR B . n 
B 2 208 HIS 208 208 208 HIS HIS B . n 
B 2 209 MET 209 209 209 MET MET B . n 
B 2 210 PHE 210 210 210 PHE PHE B . n 
B 2 211 THR 211 211 211 THR THR B . n 
B 2 212 LYS 212 212 212 LYS LYS B . n 
B 2 213 TYR 213 213 213 TYR TYR B . n 
B 2 214 GLU 214 214 214 GLU GLU B . n 
B 2 215 ASN 215 215 215 ASN ASN B . n 
B 2 216 ALA 216 216 216 ALA ALA B . n 
B 2 217 ASN 217 217 217 ASN ASN B . n 
B 2 218 PRO 218 218 218 PRO PRO B . n 
B 2 219 GLY 219 219 219 GLY GLY B . n 
B 2 220 GLU 220 220 220 GLU GLU B . n 
B 2 221 LYS 221 221 221 LYS LYS B . n 
B 2 222 GLY 222 222 222 GLY GLY B . n 
B 2 223 GLY 223 223 223 GLY GLY B . n 
B 2 224 GLU 224 224 224 GLU GLU B . n 
B 2 225 PHE 225 225 225 PHE PHE B . n 
B 2 226 LYS 226 226 226 LYS LYS B . n 
B 2 227 GLY 227 227 227 GLY GLY B . n 
B 2 228 SER 228 228 228 SER SER B . n 
B 2 229 PHE 229 229 229 PHE PHE B . n 
B 2 230 THR 230 230 230 THR THR B . n 
B 2 231 LEU 231 231 231 LEU LEU B . n 
B 2 232 ASP 232 232 232 ASP ASP B . n 
B 2 233 THR 233 233 233 THR THR B . n 
B 2 234 ASN 234 234 234 ASN ASN B . n 
B 2 235 ALA 235 235 235 ALA ALA B . n 
B 2 236 THR 236 236 236 THR THR B . n 
B 2 237 ASN 237 237 237 ASN ASN B . n 
B 2 238 PRO 238 238 238 PRO PRO B . n 
B 2 239 ALA 239 239 239 ALA ALA B . n 
B 2 240 ARG 240 240 240 ARG ARG B . n 
B 2 241 ASN 241 241 241 ASN ASN B . n 
B 2 242 PHE 242 242 242 PHE PHE B . n 
B 2 243 CYS 243 243 243 CYS CYS B . n 
B 2 244 PRO 244 244 244 PRO PRO B . n 
B 2 245 VAL 245 245 245 VAL VAL B . n 
B 2 246 ASP 246 246 246 ASP ASP B . n 
B 2 247 TYR 247 247 247 TYR TYR B . n 
B 2 248 LEU 248 248 248 LEU LEU B . n 
B 2 249 PHE 249 249 249 PHE PHE B . n 
B 2 250 GLY 250 250 250 GLY GLY B . n 
B 2 251 SER 251 251 251 SER SER B . n 
B 2 252 GLY 252 252 252 GLY GLY B . n 
B 2 253 VAL 253 253 253 VAL VAL B . n 
B 2 254 LEU 254 254 254 LEU LEU B . n 
B 2 255 ALA 255 255 255 ALA ALA B . n 
B 2 256 GLY 256 256 256 GLY GLY B . n 
B 2 257 ASN 257 257 257 ASN ASN B . n 
B 2 258 ALA 258 258 258 ALA ALA B . n 
B 2 259 PHE 259 259 259 PHE PHE B . n 
B 2 260 VAL 260 260 260 VAL VAL B . n 
B 2 261 TYR 261 261 261 TYR TYR B . n 
B 2 262 PRO 262 262 262 PRO PRO B . n 
B 2 263 HIS 263 263 263 HIS HIS B . n 
B 2 264 GLN 264 264 264 GLN GLN B . n 
B 2 265 ILE 265 265 265 ILE ILE B . n 
B 2 266 ILE 266 266 266 ILE ILE B . n 
B 2 267 ASN 267 267 267 ASN ASN B . n 
B 2 268 LEU 268 268 268 LEU LEU B . n 
B 2 269 ARG 269 269 269 ARG ARG B . n 
B 2 270 THR 270 270 270 THR THR B . n 
B 2 271 ASN 271 271 271 ASN ASN B . n 
B 2 272 ASN 272 272 272 ASN ASN B . n 
B 2 273 CYS 273 273 273 CYS CYS B . n 
B 2 274 ALA 274 274 274 ALA ALA B . n 
B 2 275 THR 275 275 275 THR THR B . n 
B 2 276 LEU 276 276 276 LEU LEU B . n 
B 2 277 VAL 277 277 277 VAL VAL B . n 
B 2 278 LEU 278 278 278 LEU LEU B . n 
B 2 279 PRO 279 279 279 PRO PRO B . n 
B 2 280 TYR 280 280 280 TYR TYR B . n 
B 2 281 VAL 281 281 281 VAL VAL B . n 
B 2 282 ASN 282 282 282 ASN ASN B . n 
B 2 283 SER 283 283 283 SER SER B . n 
B 2 284 LEU 284 284 284 LEU LEU B . n 
B 2 285 SER 285 285 285 SER SER B . n 
B 2 286 ILE 286 286 286 ILE ILE B . n 
B 2 287 ASP 287 287 287 ASP ASP B . n 
B 2 288 SER 288 288 288 SER SER B . n 
B 2 289 MET 289 289 289 MET MET B . n 
B 2 290 THR 290 290 290 THR THR B . n 
B 2 291 LYS 291 291 291 LYS LYS B . n 
B 2 292 HIS 292 292 292 HIS HIS B . n 
B 2 293 ASN 293 293 293 ASN ASN B . n 
B 2 294 ASN 294 294 294 ASN ASN B . n 
B 2 295 TRP 295 295 295 TRP TRP B . n 
B 2 296 GLY 296 296 296 GLY GLY B . n 
B 2 297 ILE 297 297 297 ILE ILE B . n 
B 2 298 ALA 298 298 298 ALA ALA B . n 
B 2 299 ILE 299 299 299 ILE ILE B . n 
B 2 300 LEU 300 300 300 LEU LEU B . n 
B 2 301 PRO 301 301 301 PRO PRO B . n 
B 2 302 LEU 302 302 302 LEU LEU B . n 
B 2 303 ALA 303 303 303 ALA ALA B . n 
B 2 304 PRO 304 304 304 PRO PRO B . n 
B 2 305 LEU 305 305 305 LEU LEU B . n 
B 2 306 ASP 306 306 306 ASP ASP B . n 
B 2 307 PHE 307 307 307 PHE PHE B . n 
B 2 308 ALA 308 308 308 ALA ALA B . n 
B 2 309 THR 309 309 309 THR THR B . n 
B 2 310 GLU 310 310 310 GLU GLU B . n 
B 2 311 SER 311 311 311 SER SER B . n 
B 2 312 SER 312 312 312 SER SER B . n 
B 2 313 THR 313 313 313 THR THR B . n 
B 2 314 GLU 314 314 314 GLU GLU B . n 
B 2 315 ILE 315 315 315 ILE ILE B . n 
B 2 316 PRO 316 316 316 PRO PRO B . n 
B 2 317 ILE 317 317 317 ILE ILE B . n 
B 2 318 THR 318 318 318 THR THR B . n 
B 2 319 LEU 319 319 319 LEU LEU B . n 
B 2 320 THR 320 320 320 THR THR B . n 
B 2 321 ILE 321 321 321 ILE ILE B . n 
B 2 322 ALA 322 322 322 ALA ALA B . n 
B 2 323 PRO 323 323 323 PRO PRO B . n 
B 2 324 MET 324 324 324 MET MET B . n 
B 2 325 CYS 325 325 325 CYS CYS B . n 
B 2 326 CYS 326 326 326 CYS CYS B . n 
B 2 327 GLU 327 327 327 GLU GLU B . n 
B 2 328 PHE 328 328 328 PHE PHE B . n 
B 2 329 ASN 329 329 329 ASN ASN B . n 
B 2 330 GLY 330 330 330 GLY GLY B . n 
B 2 331 LEU 331 331 331 LEU LEU B . n 
B 2 332 ARG 332 332 332 ARG ARG B . n 
B 2 333 ASN 333 333 333 ASN ASN B . n 
B 2 334 ILE 334 334 334 ILE ILE B . n 
B 2 335 THR 335 335 335 THR THR B . n 
B 2 336 VAL 336 336 336 VAL VAL B . n 
B 2 337 PRO 337 337 337 PRO PRO B . n 
B 2 338 ARG 338 338 338 ARG ARG B . n 
B 2 339 THR 339 339 339 THR THR B . n 
B 2 340 GLN 340 340 340 GLN GLN B . n 
C 3 1   GLY 1   1   1   GLY GLY C . n 
C 3 2   LEU 2   2   2   LEU LEU C . n 
C 3 3   PRO 3   3   3   PRO PRO C . n 
C 3 4   VAL 4   4   4   VAL VAL C . n 
C 3 5   LEU 5   5   5   LEU LEU C . n 
C 3 6   ASN 6   6   6   ASN ASN C . n 
C 3 7   THR 7   7   7   THR THR C . n 
C 3 8   PRO 8   8   8   PRO PRO C . n 
C 3 9   GLY 9   9   9   GLY GLY C . n 
C 3 10  SER 10  10  10  SER SER C . n 
C 3 11  ASN 11  11  11  ASN ASN C . n 
C 3 12  GLN 12  12  12  GLN GLN C . n 
C 3 13  TYR 13  13  13  TYR TYR C . n 
C 3 14  LEU 14  14  14  LEU LEU C . n 
C 3 15  THR 15  15  15  THR THR C . n 
C 3 16  ALA 16  16  16  ALA ALA C . n 
C 3 17  ASP 17  17  17  ASP ASP C . n 
C 3 18  ASN 18  18  18  ASN ASN C . n 
C 3 19  TYR 19  19  19  TYR TYR C . n 
C 3 20  GLN 20  20  20  GLN GLN C . n 
C 3 21  SER 21  21  21  SER SER C . n 
C 3 22  PRO 22  22  22  PRO PRO C . n 
C 3 23  CYS 23  23  23  CYS CYS C . n 
C 3 24  ALA 24  24  24  ALA ALA C . n 
C 3 25  ILE 25  25  25  ILE ILE C . n 
C 3 26  PRO 26  26  26  PRO PRO C . n 
C 3 27  GLU 27  27  27  GLU GLU C . n 
C 3 28  PHE 28  28  28  PHE PHE C . n 
C 3 29  ASP 29  29  29  ASP ASP C . n 
C 3 30  VAL 30  30  30  VAL VAL C . n 
C 3 31  THR 31  31  31  THR THR C . n 
C 3 32  PRO 32  32  32  PRO PRO C . n 
C 3 33  PRO 33  33  33  PRO PRO C . n 
C 3 34  ILE 34  34  34  ILE ILE C . n 
C 3 35  ASP 35  35  35  ASP ASP C . n 
C 3 36  ILE 36  36  36  ILE ILE C . n 
C 3 37  PRO 37  37  37  PRO PRO C . n 
C 3 38  GLY 38  38  38  GLY GLY C . n 
C 3 39  GLU 39  39  39  GLU GLU C . n 
C 3 40  VAL 40  40  40  VAL VAL C . n 
C 3 41  ARG 41  41  41  ARG ARG C . n 
C 3 42  ASN 42  42  42  ASN ASN C . n 
C 3 43  MET 43  43  43  MET MET C . n 
C 3 44  MET 44  44  44  MET MET C . n 
C 3 45  GLU 45  45  45  GLU GLU C . n 
C 3 46  LEU 46  46  46  LEU LEU C . n 
C 3 47  ALA 47  47  47  ALA ALA C . n 
C 3 48  GLU 48  48  48  GLU GLU C . n 
C 3 49  ILE 49  49  49  ILE ILE C . n 
C 3 50  ASP 50  50  50  ASP ASP C . n 
C 3 51  THR 51  51  51  THR THR C . n 
C 3 52  MET 52  52  52  MET MET C . n 
C 3 53  ILE 53  53  53  ILE ILE C . n 
C 3 54  PRO 54  54  54  PRO PRO C . n 
C 3 55  LEU 55  55  55  LEU LEU C . n 
C 3 56  ASN 56  56  56  ASN ASN C . n 
C 3 57  LEU 57  57  57  LEU LEU C . n 
C 3 58  THR 58  58  58  THR THR C . n 
C 3 59  ASN 59  59  59  ASN ASN C . n 
C 3 60  GLN 60  60  60  GLN GLN C . n 
C 3 61  ARG 61  61  61  ARG ARG C . n 
C 3 62  LYS 62  62  62  LYS LYS C . n 
C 3 63  ASN 63  63  63  ASN ASN C . n 
C 3 64  THR 64  64  64  THR THR C . n 
C 3 65  MET 65  65  65  MET MET C . n 
C 3 66  ASP 66  66  66  ASP ASP C . n 
C 3 67  MET 67  67  67  MET MET C . n 
C 3 68  TYR 68  68  68  TYR TYR C . n 
C 3 69  ARG 69  69  69  ARG ARG C . n 
C 3 70  VAL 70  70  70  VAL VAL C . n 
C 3 71  GLU 71  71  71  GLU GLU C . n 
C 3 72  LEU 72  72  72  LEU LEU C . n 
C 3 73  ASN 73  73  73  ASN ASN C . n 
C 3 74  ASP 74  74  74  ASP ASP C . n 
C 3 75  ALA 75  75  75  ALA ALA C . n 
C 3 76  ALA 76  76  76  ALA ALA C . n 
C 3 77  HIS 77  77  77  HIS HIS C . n 
C 3 78  SER 78  78  78  SER SER C . n 
C 3 79  ASP 79  79  79  ASP ASP C . n 
C 3 80  THR 80  80  80  THR THR C . n 
C 3 81  PRO 81  81  81  PRO PRO C . n 
C 3 82  ILE 82  82  82  ILE ILE C . n 
C 3 83  LEU 83  83  83  LEU LEU C . n 
C 3 84  CYS 84  84  84  CYS CYS C . n 
C 3 85  LEU 85  85  85  LEU LEU C . n 
C 3 86  SER 86  86  86  SER SER C . n 
C 3 87  LEU 87  87  87  LEU LEU C . n 
C 3 88  SER 88  88  88  SER SER C . n 
C 3 89  PRO 89  89  89  PRO PRO C . n 
C 3 90  ALA 90  90  90  ALA ALA C . n 
C 3 91  SER 91  91  91  SER SER C . n 
C 3 92  ASP 92  92  92  ASP ASP C . n 
C 3 93  PRO 93  93  93  PRO PRO C . n 
C 3 94  ARG 94  94  94  ARG ARG C . n 
C 3 95  LEU 95  95  95  LEU LEU C . n 
C 3 96  ALA 96  96  96  ALA ALA C . n 
C 3 97  HIS 97  97  97  HIS HIS C . n 
C 3 98  THR 98  98  98  THR THR C . n 
C 3 99  MET 99  99  99  MET MET C . n 
C 3 100 LEU 100 100 100 LEU LEU C . n 
C 3 101 GLY 101 101 101 GLY GLY C . n 
C 3 102 GLU 102 102 102 GLU GLU C . n 
C 3 103 ILE 103 103 103 ILE ILE C . n 
C 3 104 LEU 104 104 104 LEU LEU C . n 
C 3 105 ASN 105 105 105 ASN ASN C . n 
C 3 106 TYR 106 106 106 TYR TYR C . n 
C 3 107 TYR 107 107 107 TYR TYR C . n 
C 3 108 THR 108 108 108 THR THR C . n 
C 3 109 HIS 109 109 109 HIS HIS C . n 
C 3 110 TRP 110 110 110 TRP TRP C . n 
C 3 111 ALA 111 111 111 ALA ALA C . n 
C 3 112 GLY 112 112 112 GLY GLY C . n 
C 3 113 SER 113 113 113 SER SER C . n 
C 3 114 LEU 114 114 114 LEU LEU C . n 
C 3 115 LYS 115 115 115 LYS LYS C . n 
C 3 116 PHE 116 116 116 PHE PHE C . n 
C 3 117 THR 117 117 117 THR THR C . n 
C 3 118 PHE 118 118 118 PHE PHE C . n 
C 3 119 LEU 119 119 119 LEU LEU C . n 
C 3 120 PHE 120 120 120 PHE PHE C . n 
C 3 121 CYS 121 121 121 CYS CYS C . n 
C 3 122 GLY 122 122 122 GLY GLY C . n 
C 3 123 SER 123 123 123 SER SER C . n 
C 3 124 MET 124 124 124 MET MET C . n 
C 3 125 MET 125 125 125 MET MET C . n 
C 3 126 ALA 126 126 126 ALA ALA C . n 
C 3 127 THR 127 127 127 THR THR C . n 
C 3 128 GLY 128 128 128 GLY GLY C . n 
C 3 129 LYS 129 129 129 LYS LYS C . n 
C 3 130 LEU 130 130 130 LEU LEU C . n 
C 3 131 LEU 131 131 131 LEU LEU C . n 
C 3 132 VAL 132 132 132 VAL VAL C . n 
C 3 133 SER 133 133 133 SER SER C . n 
C 3 134 TYR 134 134 134 TYR TYR C . n 
C 3 135 ALA 135 135 135 ALA ALA C . n 
C 3 136 PRO 136 136 136 PRO PRO C . n 
C 3 137 PRO 137 137 137 PRO PRO C . n 
C 3 138 GLY 138 138 138 GLY GLY C . n 
C 3 139 ALA 139 139 139 ALA ALA C . n 
C 3 140 GLU 140 140 140 GLU GLU C . n 
C 3 141 ALA 141 141 141 ALA ALA C . n 
C 3 142 PRO 142 142 142 PRO PRO C . n 
C 3 143 LYS 143 143 143 LYS LYS C . n 
C 3 144 SER 144 144 144 SER SER C . n 
C 3 145 ARG 145 145 145 ARG ARG C . n 
C 3 146 LYS 146 146 146 LYS LYS C . n 
C 3 147 GLU 147 147 147 GLU GLU C . n 
C 3 148 ALA 148 148 148 ALA ALA C . n 
C 3 149 MET 149 149 149 MET MET C . n 
C 3 150 LEU 150 150 150 LEU LEU C . n 
C 3 151 GLY 151 151 151 GLY GLY C . n 
C 3 152 THR 152 152 152 THR THR C . n 
C 3 153 HIS 153 153 153 HIS HIS C . n 
C 3 154 VAL 154 154 154 VAL VAL C . n 
C 3 155 ILE 155 155 155 ILE ILE C . n 
C 3 156 TRP 156 156 156 TRP TRP C . n 
C 3 157 ASP 157 157 157 ASP ASP C . n 
C 3 158 ILE 158 158 158 ILE ILE C . n 
C 3 159 GLY 159 159 159 GLY GLY C . n 
C 3 160 LEU 160 160 160 LEU LEU C . n 
C 3 161 GLN 161 161 161 GLN GLN C . n 
C 3 162 SER 162 162 162 SER SER C . n 
C 3 163 SER 163 163 163 SER SER C . n 
C 3 164 CYS 164 164 164 CYS CYS C . n 
C 3 165 THR 165 165 165 THR THR C . n 
C 3 166 MET 166 166 166 MET MET C . n 
C 3 167 VAL 167 167 167 VAL VAL C . n 
C 3 168 VAL 168 168 168 VAL VAL C . n 
C 3 169 PRO 169 169 169 PRO PRO C . n 
C 3 170 TRP 170 170 170 TRP TRP C . n 
C 3 171 ILE 171 171 171 ILE ILE C . n 
C 3 172 SER 172 172 172 SER SER C . n 
C 3 173 ASN 173 173 173 ASN ASN C . n 
C 3 174 THR 174 174 174 THR THR C . n 
C 3 175 THR 175 175 175 THR THR C . n 
C 3 176 TYR 176 176 176 TYR TYR C . n 
C 3 177 ARG 177 177 177 ARG ARG C . n 
C 3 178 LEU 178 178 178 LEU LEU C . n 
C 3 179 THR 179 179 179 THR THR C . n 
C 3 180 ILE 180 180 180 ILE ILE C . n 
C 3 181 ASN 181 181 181 ASN ASN C . n 
C 3 182 ASP 182 182 182 ASP ASP C . n 
C 3 183 SER 183 183 183 SER SER C . n 
C 3 184 PHE 184 184 184 PHE PHE C . n 
C 3 185 THR 185 185 185 THR THR C . n 
C 3 186 GLU 186 186 186 GLU GLU C . n 
C 3 187 GLY 187 187 187 GLY GLY C . n 
C 3 188 GLY 188 188 188 GLY GLY C . n 
C 3 189 TYR 189 189 189 TYR TYR C . n 
C 3 190 ILE 190 190 190 ILE ILE C . n 
C 3 191 SER 191 191 191 SER SER C . n 
C 3 192 MET 192 192 192 MET MET C . n 
C 3 193 PHE 193 193 193 PHE PHE C . n 
C 3 194 TYR 194 194 194 TYR TYR C . n 
C 3 195 GLN 195 195 195 GLN GLN C . n 
C 3 196 THR 196 196 196 THR THR C . n 
C 3 197 ARG 197 197 197 ARG ARG C . n 
C 3 198 VAL 198 198 198 VAL VAL C . n 
C 3 199 VAL 199 199 199 VAL VAL C . n 
C 3 200 VAL 200 200 200 VAL VAL C . n 
C 3 201 PRO 201 201 201 PRO PRO C . n 
C 3 202 LEU 202 202 202 LEU LEU C . n 
C 3 203 SER 203 203 203 SER SER C . n 
C 3 204 THR 204 204 204 THR THR C . n 
C 3 205 PRO 205 205 205 PRO PRO C . n 
C 3 206 ARG 206 206 206 ARG ARG C . n 
C 3 207 LYS 207 207 207 LYS LYS C . n 
C 3 208 MET 208 208 208 MET MET C . n 
C 3 209 ASP 209 209 209 ASP ASP C . n 
C 3 210 ILE 210 210 210 ILE ILE C . n 
C 3 211 LEU 211 211 211 LEU LEU C . n 
C 3 212 GLY 212 212 212 GLY GLY C . n 
C 3 213 PHE 213 213 213 PHE PHE C . n 
C 3 214 VAL 214 214 214 VAL VAL C . n 
C 3 215 SER 215 215 215 SER SER C . n 
C 3 216 ALA 216 216 216 ALA ALA C . n 
C 3 217 CYS 217 217 217 CYS CYS C . n 
C 3 218 ASN 218 218 218 ASN ASN C . n 
C 3 219 ASP 219 219 219 ASP ASP C . n 
C 3 220 PHE 220 220 220 PHE PHE C . n 
C 3 221 SER 221 221 221 SER SER C . n 
C 3 222 VAL 222 222 222 VAL VAL C . n 
C 3 223 ARG 223 223 223 ARG ARG C . n 
C 3 224 LEU 224 224 224 LEU LEU C . n 
C 3 225 LEU 225 225 225 LEU LEU C . n 
C 3 226 ARG 226 226 226 ARG ARG C . n 
C 3 227 ASP 227 227 227 ASP ASP C . n 
C 3 228 THR 228 228 228 THR THR C . n 
C 3 229 THR 229 229 229 THR THR C . n 
C 3 230 HIS 230 230 230 HIS HIS C . n 
C 3 231 ILE 231 231 231 ILE ILE C . n 
C 3 232 SER 232 232 232 SER SER C . n 
C 3 233 GLN 233 233 233 GLN GLN C . n 
C 3 234 GLU 234 234 234 GLU GLU C . n 
C 3 235 ALA 235 235 ?   ?   ?   C . n 
C 3 236 MET 236 236 ?   ?   ?   C . n 
C 3 237 PRO 237 237 ?   ?   ?   C . n 
C 3 238 GLN 238 238 ?   ?   ?   C . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        SPH 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   SPH 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
_pdbx_nonpoly_scheme.asym_id         D 
_pdbx_nonpoly_scheme.entity_id       4 
_pdbx_nonpoly_scheme.mon_id          SPH 
_pdbx_nonpoly_scheme.ndb_seq_num     1 
_pdbx_nonpoly_scheme.pdb_seq_num     401 
_pdbx_nonpoly_scheme.auth_seq_num    401 
_pdbx_nonpoly_scheme.pdb_mon_id      SPH 
_pdbx_nonpoly_scheme.auth_mon_id     SPH 
_pdbx_nonpoly_scheme.pdb_strand_id   A 
_pdbx_nonpoly_scheme.pdb_ins_code    . 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9H93 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9H93 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9H93 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9H93 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.40 
_refine.ls_d_res_low                             ? 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    ? 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       ? 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'REAL-SPACE (WEIGHTED MAP SUM AT ATOM CENTERS)' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           ? 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.003  ? 33744 ? f_bond_d           ? ? 
'ELECTRON MICROSCOPY' ? 0.546  ? 45984 ? f_angle_d          ? ? 
'ELECTRON MICROSCOPY' ? 12.078 ? 12150 ? f_dihedral_angle_d ? ? 
'ELECTRON MICROSCOPY' ? 0.044  ? 5064  ? f_chiral_restr     ? ? 
'ELECTRON MICROSCOPY' ? 0.004  ? 5892  ? f_plane_restr      ? ? 
# 
_struct.entry_id                     9H93 
_struct.title                        
'Poliovirus type 2 (strain MEF-1) stabilised virus-like particle (PV2 SC6b) from a yeast expression system.' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9H93 
_struct_keywords.text            'Capsid protein, virus-like particle, vaccine, VIRUS LIKE PARTICLE' 
_struct_keywords.pdbx_keywords   'VIRUS LIKE PARTICLE' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP Q8QNU4_9ENTO     Q8QNU4     ? 1 
;GLGDLIEGVVEGVTRNALTPLTPANNLPDTQSSGPAHSKETPALTAVETGATNPLVPSDTVQTRHVIQKRTRSESTVESF
FARGACVAIIEVDNDAPTKRASKLFSVWKITYKDTVQLRRKLEFFTYSRFDMEFTFVVTSNYTDANNGHALNQVYQIMYI
PPGAPIPGKWNDYTWQTSSNPSVFYTYGAPPARISVPYVGIANAYSHFYDGFAKVPLAGQASTEGDSLYGAASLNDFGSL
AVRVVNDHNPTKLTSKIRVYMKPKHVRVWCPRPPRAVPYYGPGVDYKDGLAPLPEKGLTTY
;
1   
2 UNP POLG_POL2L       P06210     ? 2 
;MGAQVSSQKVGAHENSNRAYGGSTINYTTINYYRDSASNAASKQDFAQDPSKFTEPIKDVLIKTAPTLNSPNIEACGYSD
RVMQLTLGNSTITTQEAANSVVAYGRWPEYIKDSEANPVDQPTEPDVAACRFYTLDTVTWRKESRGWWWKLPDALKDMGL
FGQNMFYHYLGRAGYTVHVQCNASKFHQGALGVFAVPEMCLAGDSTTHMFTKYENANPGEKGGEFKGSFTLDTNATNPAR
NFCPVDYLFGSGVLAGNAFVYPHQIINLRTNNCATLVLPYVNSLSIDSMTKHNNWGIAILPLAPLDFATESSTEIPITLT
IAPMCCEFNGLRNITVPRTQ
;
1   
3 UNP A0A0K1U2R1_9ENTO A0A0K1U2R1 ? 3 
;GLPVLNTPGSNQYLTADNYQSPCAIPEFDVTPPIDIPGEVRNMMELAEIDTMIPLNLTNQRKNTMDMYRVELNDAAHSDT
PILCLSLSPASDPRLAHTMLGEILNYYTHWAGSLKFTFLFCGSMMATGKLLVSYAPPGAEAPKSRKEAMLGTHVIWDIGL
QSSCTMVVPWISNTTYRQTINDSFTEGGYISMFYQTRVVVPLSTPRKMDILGFVSACNDFSVRLLRDTTHISQEAMPQ
;
341 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9H93 A 1 ? 301 ? Q8QNU4     1   ? 301 ? 1 301 
2 2 9H93 B 1 ? 340 ? P06210     1   ? 340 ? 1 340 
3 3 9H93 C 1 ? 238 ? A0A0K1U2R1 341 ? 578 ? 1 238 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9H93 ILE A 107 ? UNP Q8QNU4     VAL 107 'engineered mutation' 107 1 
1 9H93 LEU A 134 ? UNP Q8QNU4     PHE 134 'engineered mutation' 134 2 
1 9H93 LEU A 183 ? UNP Q8QNU4     VAL 183 'engineered mutation' 183 3 
2 9H93 VAL B 57  ? UNP P06210     ILE 57  'engineered mutation' 57  4 
2 9H93 ALA B 126 ? UNP P06210     ASP 126 'engineered mutation' 126 5 
3 9H93 LEU C 178 ? UNP A0A0K1U2R1 GLN 518 'engineered mutation' 178 6 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   180-meric 
_pdbx_struct_assembly.oligomeric_count     180 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   
;1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60
;
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1  'identity operation'       1_555 x,y,z 1.0       0.0       0.0       0.0        0.0       1.0       0.0       0.0        0.0 
0.0       1.0       0.0        
2  'point symmetry operation' ?     ?     -0.809017 -0.500000 0.309017  478.65600  -0.500000 0.309017  -0.809017 478.65600  
0.309017  -0.809017 -0.500000 478.65600  
3  'point symmetry operation' ?     ?     0.0       1.0       0.0       0.0        0.0       0.0       -1.0      478.65600  -1.0 
0.0       0.0       478.65600  
4  'point symmetry operation' ?     ?     0.809017  -0.500000 -0.309017 239.32800  -0.500000 -0.309017 -0.809017 626.56884  
0.309017  0.809017  -0.500000 91.41516   
5  'point symmetry operation' ?     ?     0.500000  0.309017  -0.809017 239.32800  -0.309017 -0.809017 -0.500000 626.56884  
-0.809017 0.500000  -0.309017 387.24084  
6  'point symmetry operation' ?     ?     -0.309017 -0.809017 -0.500000 626.56884  -0.809017 0.500000  -0.309017 387.24084  
0.500000  0.309017  -0.809017 239.32800  
7  'point symmetry operation' ?     ?     -0.809017 0.500000  -0.309017 387.24084  0.500000  0.309017  -0.809017 239.32800  
-0.309017 -0.809017 -0.500000 626.56884  
8  'point symmetry operation' ?     ?     -0.809017 -0.500000 -0.309017 626.56884  0.500000  -0.309017 -0.809017 387.24084  
0.309017  -0.809017 0.500000  239.32800  
9  'point symmetry operation' ?     ?     -0.309017 0.809017  -0.500000 239.32800  -0.809017 -0.500000 -0.309017 626.56884  
-0.500000 0.309017  0.809017  91.41516   
10 'point symmetry operation' ?     ?     0.500000  -0.309017 -0.809017 387.24084  -0.309017 0.809017  -0.500000 239.32800  
0.809017  0.500000  0.309017  -147.91284 
11 'point symmetry operation' ?     ?     0.0       0.0       -1.0      478.65600  -1.0      0.0       0.0       478.65600  0.0 
1.0       0.0       0.0        
12 'point symmetry operation' ?     ?     -0.500000 -0.309017 -0.809017 626.56884  0.309017  0.809017  -0.500000 91.41516   
0.809017  -0.500000 -0.309017 239.32800  
13 'point symmetry operation' ?     ?     -0.500000 0.309017  -0.809017 478.65600  0.309017  -0.809017 -0.500000 478.65600  
-0.809017 -0.500000 0.309017  478.65600  
14 'point symmetry operation' ?     ?     -0.309017 -0.809017 -0.500000 626.56884  0.809017  -0.500000 0.309017  91.41516   
-0.500000 -0.309017 0.809017  239.32800  
15 'point symmetry operation' ?     ?     -0.809017 0.500000  -0.309017 387.24084  -0.500000 -0.309017 0.809017  239.32800  
0.309017  0.809017  0.500000  -147.91284 
16 'point symmetry operation' ?     ?     0.500000  0.309017  -0.809017 239.32800  0.309017  0.809017  0.500000  -147.91284 
0.809017  -0.500000 0.309017  91.41516   
17 'point symmetry operation' ?     ?     -0.500000 0.309017  -0.809017 478.65600  -0.309017 0.809017  0.500000  0.0        
0.809017  0.500000  -0.309017 0.0        
18 'point symmetry operation' ?     ?     0.0       0.0       -1.0      478.65600  1.0       0.0       0.0       0.0        0.0 
-1.0      0.0       478.65600  
19 'point symmetry operation' ?     ?     -0.500000 -0.309017 -0.809017 626.56884  -0.309017 -0.809017 0.500000  387.24084  
-0.809017 0.500000  0.309017  239.32800  
20 'point symmetry operation' ?     ?     0.0       -1.0      0.0       478.65600  0.0       0.0       1.0       0.0        -1.0 
0.0       0.0       478.65600  
21 'point symmetry operation' ?     ?     -0.809017 0.500000  0.309017  239.32800  0.500000  0.309017  0.809017  -147.91284 
0.309017  0.809017  -0.500000 91.41516   
22 'point symmetry operation' ?     ?     0.809017  0.500000  -0.309017 0.0        0.500000  -0.309017 0.809017  0.0        
0.309017  -0.809017 -0.500000 478.65600  
23 'point symmetry operation' ?     ?     -0.309017 0.809017  -0.500000 239.32800  0.809017  0.500000  0.309017  -147.91284 
0.500000  -0.309017 -0.809017 387.24084  
24 'point symmetry operation' ?     ?     0.500000  -0.309017 -0.809017 387.24084  0.309017  -0.809017 0.500000  239.32800  
-0.809017 -0.500000 -0.309017 626.56884  
25 'point symmetry operation' ?     ?     -0.809017 -0.500000 -0.309017 626.56884  -0.500000 0.309017  0.809017  91.41516   
-0.309017 0.809017  -0.500000 239.32800  
26 'point symmetry operation' ?     ?     -0.309017 -0.809017 0.500000  387.24084  -0.809017 0.500000  0.309017  239.32800  
-0.500000 -0.309017 -0.809017 626.56884  
27 'point symmetry operation' ?     ?     -0.309017 0.809017  0.500000  0.0        0.809017  0.500000  -0.309017 0.0        
-0.500000 0.309017  -0.809017 478.65600  
28 'point symmetry operation' ?     ?     1.0       0.0       0.0       0.0        0.0       -1.0      0.0       478.65600  0.0 
0.0       -1.0      478.65600  
29 'point symmetry operation' ?     ?     0.309017  0.809017  -0.500000 91.41516   0.809017  -0.500000 -0.309017 239.32800  
-0.500000 -0.309017 -0.809017 626.56884  
30 'point symmetry operation' ?     ?     0.309017  -0.809017 -0.500000 478.65600  -0.809017 -0.500000 0.309017  478.65600  
-0.500000 0.309017  -0.809017 478.65600  
31 'point symmetry operation' ?     ?     -1.0      0.0       0.0       478.65600  0.0       1.0       0.0       0.0        0.0 
0.0       -1.0      478.65600  
32 'point symmetry operation' ?     ?     0.809017  0.500000  -0.309017 0.0        -0.500000 0.309017  -0.809017 478.65600  
-0.309017 0.809017  0.500000  0.0        
33 'point symmetry operation' ?     ?     0.0       -1.0      0.0       478.65600  0.0       0.0       -1.0      478.65600  1.0 
0.0       0.0       0.0        
34 'point symmetry operation' ?     ?     -0.809017 0.500000  0.309017  239.32800  -0.500000 -0.309017 -0.809017 626.56884  
-0.309017 -0.809017 0.500000  387.24084  
35 'point symmetry operation' ?     ?     -0.500000 -0.309017 0.809017  239.32800  -0.309017 -0.809017 -0.500000 626.56884  
0.809017  -0.500000 0.309017  91.41516   
36 'point symmetry operation' ?     ?     0.309017  0.809017  0.500000  -147.91284 -0.809017 0.500000  -0.309017 387.24084  
-0.500000 -0.309017 0.809017  239.32800  
37 'point symmetry operation' ?     ?     0.809017  -0.500000 0.309017  91.41516   0.500000  0.309017  -0.809017 239.32800  
0.309017  0.809017  0.500000  -147.91284 
38 'point symmetry operation' ?     ?     0.809017  0.500000  0.309017  -147.91284 0.500000  -0.309017 -0.809017 387.24084  
-0.309017 0.809017  -0.500000 239.32800  
39 'point symmetry operation' ?     ?     0.309017  -0.809017 0.500000  239.32800  -0.809017 -0.500000 -0.309017 626.56884  
0.500000  -0.309017 -0.809017 387.24084  
40 'point symmetry operation' ?     ?     -0.500000 0.309017  0.809017  91.41516   -0.309017 0.809017  -0.500000 239.32800  
-0.809017 -0.500000 -0.309017 626.56884  
41 'point symmetry operation' ?     ?     0.0       0.0       1.0       0.0        -1.0      0.0       0.0       478.65600  0.0 
-1.0      0.0       478.65600  
42 'point symmetry operation' ?     ?     0.500000  0.309017  0.809017  -147.91284 0.309017  0.809017  -0.500000 91.41516   
-0.809017 0.500000  0.309017  239.32800  
43 'point symmetry operation' ?     ?     0.500000  -0.309017 0.809017  0.0        0.309017  -0.809017 -0.500000 478.65600  
0.809017  0.500000  -0.309017 0.0        
44 'point symmetry operation' ?     ?     0.309017  0.809017  0.500000  -147.91284 0.809017  -0.500000 0.309017  91.41516   
0.500000  0.309017  -0.809017 239.32800  
45 'point symmetry operation' ?     ?     0.809017  -0.500000 0.309017  91.41516   -0.500000 -0.309017 0.809017  239.32800  
-0.309017 -0.809017 -0.500000 626.56884  
46 'point symmetry operation' ?     ?     -0.500000 -0.309017 0.809017  239.32800  0.309017  0.809017  0.500000  -147.91284 
-0.809017 0.500000  -0.309017 387.24084  
47 'point symmetry operation' ?     ?     0.500000  -0.309017 0.809017  0.0        -0.309017 0.809017  0.500000  0.0        
-0.809017 -0.500000 0.309017  478.65600  
48 'point symmetry operation' ?     ?     0.0       0.0       1.0       0.0        1.0       0.0       0.0       0.0        0.0 
1.0       0.0       0.0        
49 'point symmetry operation' ?     ?     0.500000  0.309017  0.809017  -147.91284 -0.309017 -0.809017 0.500000  387.24084  
0.809017  -0.500000 -0.309017 239.32800  
50 'point symmetry operation' ?     ?     0.0       1.0       0.0       0.0        0.0       0.0       1.0       0.0        1.0 
0.0       0.0       0.0        
51 'point symmetry operation' ?     ?     0.809017  -0.500000 -0.309017 239.32800  0.500000  0.309017  0.809017  -147.91284 
-0.309017 -0.809017 0.500000  387.24084  
52 'point symmetry operation' ?     ?     -0.809017 -0.500000 0.309017  478.65600  0.500000  -0.309017 0.809017  0.0        
-0.309017 0.809017  0.500000  0.0        
53 'point symmetry operation' ?     ?     0.309017  -0.809017 0.500000  239.32800  0.809017  0.500000  0.309017  -147.91284 
-0.500000 0.309017  0.809017  91.41516   
54 'point symmetry operation' ?     ?     -0.500000 0.309017  0.809017  91.41516   0.309017  -0.809017 0.500000  239.32800  
0.809017  0.500000  0.309017  -147.91284 
55 'point symmetry operation' ?     ?     0.809017  0.500000  0.309017  -147.91284 -0.500000 0.309017  0.809017  91.41516   
0.309017  -0.809017 0.500000  239.32800  
56 'point symmetry operation' ?     ?     0.309017  0.809017  -0.500000 91.41516   -0.809017 0.500000  0.309017  239.32800  
0.500000  0.309017  0.809017  -147.91284 
57 'point symmetry operation' ?     ?     0.309017  -0.809017 -0.500000 478.65600  0.809017  0.500000  -0.309017 0.0        
0.500000  -0.309017 0.809017  0.0        
58 'point symmetry operation' ?     ?     -1.0      0.0       0.0       478.65600  0.0       -1.0      0.0       478.65600  0.0 
0.0       1.0       0.0        
59 'point symmetry operation' ?     ?     -0.309017 -0.809017 0.500000  387.24084  0.809017  -0.500000 -0.309017 239.32800  
0.500000  0.309017  0.809017  -147.91284 
60 'point symmetry operation' ?     ?     -0.309017 0.809017  0.500000  0.0        -0.809017 -0.500000 0.309017  478.65600  
0.500000  -0.309017 0.809017  0.0        
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ARG A 72  ? SER A 75  ? ARG A 72  SER A 75  5 ? 4  
HELX_P HELX_P2  AA2 THR A 76  ? ALA A 82  ? THR A 76  ALA A 82  1 ? 7  
HELX_P HELX_P3  AA3 VAL A 116 ? GLU A 123 ? VAL A 116 GLU A 123 1 ? 8  
HELX_P HELX_P4  AA4 ASP A 172 ? THR A 177 ? ASP A 172 THR A 177 5 ? 6  
HELX_P HELX_P5  AA5 ALA A 232 ? ASP A 236 ? ALA A 232 ASP A 236 5 ? 5  
HELX_P HELX_P6  AA6 TYR B 104 ? ARG B 106 ? TYR B 104 ARG B 106 5 ? 3  
HELX_P HELX_P7  AA7 PRO B 152 ? LYS B 156 ? PRO B 152 LYS B 156 5 ? 5  
HELX_P HELX_P8  AA8 MET B 158 ? TYR B 167 ? MET B 158 TYR B 167 1 ? 10 
HELX_P HELX_P9  AA9 LYS B 212 ? ASN B 217 ? LYS B 212 ASN B 217 1 ? 6  
HELX_P HELX_P10 AB1 LEU B 254 ? TYR B 261 ? LEU B 254 TYR B 261 5 ? 8  
HELX_P HELX_P11 AB2 MET C 43  ? GLU C 48  ? MET C 43  GLU C 48  1 ? 6  
HELX_P HELX_P12 AB3 THR C 64  ? ARG C 69  ? THR C 64  ARG C 69  5 ? 6  
HELX_P HELX_P13 AB4 ASP C 92  ? HIS C 97  ? ASP C 92  HIS C 97  1 ? 6  
HELX_P HELX_P14 AB5 THR C 98  ? ASN C 105 ? THR C 98  ASN C 105 1 ? 8  
HELX_P HELX_P15 AB6 SER C 144 ? MET C 149 ? SER C 144 MET C 149 1 ? 6  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_conn.id                            disulf1 
_struct_conn.conn_type_id                  disulf 
_struct_conn.pdbx_leaving_atom_flag        ? 
_struct_conn.pdbx_PDB_id                   ? 
_struct_conn.ptnr1_label_asym_id           B 
_struct_conn.ptnr1_label_comp_id           CYS 
_struct_conn.ptnr1_label_seq_id            130 
_struct_conn.ptnr1_label_atom_id           SG 
_struct_conn.pdbx_ptnr1_label_alt_id       ? 
_struct_conn.pdbx_ptnr1_PDB_ins_code       ? 
_struct_conn.pdbx_ptnr1_standard_comp_id   ? 
_struct_conn.ptnr1_symmetry                1_555 
_struct_conn.ptnr2_label_asym_id           B 
_struct_conn.ptnr2_label_comp_id           CYS 
_struct_conn.ptnr2_label_seq_id            326 
_struct_conn.ptnr2_label_atom_id           SG 
_struct_conn.pdbx_ptnr2_label_alt_id       ? 
_struct_conn.pdbx_ptnr2_PDB_ins_code       ? 
_struct_conn.ptnr1_auth_asym_id            B 
_struct_conn.ptnr1_auth_comp_id            CYS 
_struct_conn.ptnr1_auth_seq_id             130 
_struct_conn.ptnr2_auth_asym_id            B 
_struct_conn.ptnr2_auth_comp_id            CYS 
_struct_conn.ptnr2_auth_seq_id             326 
_struct_conn.ptnr2_symmetry                1_555 
_struct_conn.pdbx_ptnr3_label_atom_id      ? 
_struct_conn.pdbx_ptnr3_label_seq_id       ? 
_struct_conn.pdbx_ptnr3_label_comp_id      ? 
_struct_conn.pdbx_ptnr3_label_asym_id      ? 
_struct_conn.pdbx_ptnr3_label_alt_id       ? 
_struct_conn.pdbx_ptnr3_PDB_ins_code       ? 
_struct_conn.details                       ? 
_struct_conn.pdbx_dist_value               2.029 
_struct_conn.pdbx_value_order              ? 
_struct_conn.pdbx_role                     ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      CYS 
_pdbx_modification_feature.label_asym_id                      B 
_pdbx_modification_feature.label_seq_id                       130 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     CYS 
_pdbx_modification_feature.modified_residue_label_asym_id     B 
_pdbx_modification_feature.modified_residue_label_seq_id      326 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       CYS 
_pdbx_modification_feature.auth_asym_id                       B 
_pdbx_modification_feature.auth_seq_id                        130 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      CYS 
_pdbx_modification_feature.modified_residue_auth_asym_id      B 
_pdbx_modification_feature.modified_residue_auth_seq_id       326 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          1_555 
_pdbx_modification_feature.comp_id_linking_atom               SG 
_pdbx_modification_feature.modified_residue_id_linking_atom   SG 
_pdbx_modification_feature.modified_residue_id                . 
_pdbx_modification_feature.ref_pcm_id                         . 
_pdbx_modification_feature.ref_comp_id                        . 
_pdbx_modification_feature.type                               None 
_pdbx_modification_feature.category                           'Disulfide bridge' 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          LEU 
_struct_mon_prot_cis.label_seq_id           151 
_struct_mon_prot_cis.label_asym_id          B 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           LEU 
_struct_mon_prot_cis.auth_seq_id            151 
_struct_mon_prot_cis.auth_asym_id           B 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    152 
_struct_mon_prot_cis.pdbx_label_asym_id_2   B 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     152 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    B 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       9.22 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 4 ? 
AA3 ? 4 ? 
AA4 ? 5 ? 
AA5 ? 5 ? 
AA6 ? 5 ? 
AA7 ? 3 ? 
AA8 ? 4 ? 
AA9 ? 4 ? 
AB1 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA4 1 2 ? parallel      
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA4 4 5 ? anti-parallel 
AA5 1 2 ? parallel      
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA5 4 5 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
AA6 4 5 ? anti-parallel 
AA7 1 2 ? anti-parallel 
AA7 2 3 ? anti-parallel 
AA8 1 2 ? anti-parallel 
AA8 2 3 ? anti-parallel 
AA8 3 4 ? anti-parallel 
AA9 1 2 ? anti-parallel 
AA9 2 3 ? anti-parallel 
AA9 3 4 ? anti-parallel 
AB1 1 2 ? anti-parallel 
AB1 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ALA A 85  ? ASN A 94  ? ALA A 85  ASN A 94  
AA1 2 LEU A 253 ? PRO A 271 ? LEU A 253 PRO A 271 
AA1 3 PHE A 125 ? TYR A 142 ? PHE A 125 TYR A 142 
AA1 4 TYR A 205 ? SER A 206 ? TYR A 205 SER A 206 
AA2 1 ALA A 192 ? VAL A 196 ? ALA A 192 VAL A 196 
AA2 2 PHE A 125 ? TYR A 142 ? PHE A 125 TYR A 142 
AA2 3 LEU A 253 ? PRO A 271 ? LEU A 253 PRO A 271 
AA2 4 GLU C 39  ? VAL C 40  ? GLU C 39  VAL C 40  
AA3 1 PHE A 105 ? LYS A 109 ? PHE A 105 LYS A 109 
AA3 2 SER A 239 ? VAL A 244 ? SER A 239 VAL A 244 
AA3 3 VAL A 154 ? ILE A 160 ? VAL A 154 ILE A 160 
AA3 4 SER A 182 ? THR A 186 ? SER A 182 THR A 186 
AA4 1 SER B 100 ? VAL B 102 ? SER B 100 VAL B 102 
AA4 2 CYS B 273 ? LEU B 278 ? CYS B 273 LEU B 278 
AA4 3 HIS B 168 ? GLN B 180 ? HIS B 168 GLN B 180 
AA4 4 ILE B 315 ? LEU B 331 ? ILE B 315 LEU B 331 
AA4 5 TYR B 133 ? THR B 134 ? TYR B 133 THR B 134 
AA5 1 SER B 100 ? VAL B 102 ? SER B 100 VAL B 102 
AA5 2 CYS B 273 ? LEU B 278 ? CYS B 273 LEU B 278 
AA5 3 HIS B 168 ? GLN B 180 ? HIS B 168 GLN B 180 
AA5 4 ILE B 315 ? LEU B 331 ? ILE B 315 LEU B 331 
AA5 5 VAL B 138 ? TRP B 140 ? VAL B 138 TRP B 140 
AA6 1 GLY B 223 ? GLU B 224 ? GLY B 223 GLU B 224 
AA6 2 TRP B 147 ? LEU B 151 ? TRP B 147 LEU B 151 
AA6 3 TRP B 295 ? PHE B 307 ? TRP B 295 PHE B 307 
AA6 4 HIS B 187 ? PRO B 197 ? HIS B 187 PRO B 197 
AA6 5 HIS B 263 ? ASN B 267 ? HIS B 263 ASN B 267 
AA7 1 THR C 51  ? MET C 52  ? THR C 51  MET C 52  
AA7 2 LYS C 207 ? ALA C 216 ? LYS C 207 ALA C 216 
AA7 3 VAL C 70  ? ASN C 73  ? VAL C 70  ASN C 73  
AA8 1 THR C 51  ? MET C 52  ? THR C 51  MET C 52  
AA8 2 LYS C 207 ? ALA C 216 ? LYS C 207 ALA C 216 
AA8 3 LEU C 114 ? PHE C 120 ? LEU C 114 PHE C 120 
AA8 4 SER C 163 ? VAL C 168 ? SER C 163 VAL C 168 
AA9 1 LEU C 83  ? SER C 86  ? LEU C 83  SER C 86  
AA9 2 TYR C 189 ? TYR C 194 ? TYR C 189 TYR C 194 
AA9 3 LYS C 129 ? ALA C 135 ? LYS C 129 ALA C 135 
AA9 4 THR C 152 ? ASP C 157 ? THR C 152 ASP C 157 
AB1 1 ARG C 177 ? LEU C 178 ? ARG C 177 LEU C 178 
AB1 2 HIS C 109 ? ALA C 111 ? HIS C 109 ALA C 111 
AB1 3 SER C 221 ? ARG C 223 ? SER C 221 ARG C 223 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ALA A 85  ? N ALA A 85  O MET A 261 ? O MET A 261 
AA1 2 3 O ARG A 258 ? O ARG A 258 N VAL A 137 ? N VAL A 137 
AA1 3 4 N SER A 128 ? N SER A 128 O TYR A 205 ? O TYR A 205 
AA2 1 2 O VAL A 196 ? O VAL A 196 N MET A 132 ? N MET A 132 
AA2 2 3 N VAL A 137 ? N VAL A 137 O ARG A 258 ? O ARG A 258 
AA2 3 4 N VAL A 268 ? N VAL A 268 O VAL C 40  ? O VAL C 40  
AA3 1 2 N SER A 106 ? N SER A 106 O VAL A 242 ? O VAL A 242 
AA3 2 3 O ALA A 241 ? O ALA A 241 N MET A 158 ? N MET A 158 
AA3 3 4 N TYR A 155 ? N TYR A 155 O TYR A 185 ? O TYR A 185 
AA4 1 2 N VAL B 101 ? N VAL B 101 O VAL B 277 ? O VAL B 277 
AA4 2 3 O LEU B 276 ? O LEU B 276 N VAL B 177 ? N VAL B 177 
AA4 3 4 N LEU B 170 ? N LEU B 170 O ASN B 329 ? O ASN B 329 
AA4 4 5 O ILE B 321 ? O ILE B 321 N TYR B 133 ? N TYR B 133 
AA5 1 2 N VAL B 101 ? N VAL B 101 O VAL B 277 ? O VAL B 277 
AA5 2 3 O LEU B 276 ? O LEU B 276 N VAL B 177 ? N VAL B 177 
AA5 3 4 N LEU B 170 ? N LEU B 170 O ASN B 329 ? O ASN B 329 
AA5 4 5 O ILE B 315 ? O ILE B 315 N TRP B 140 ? N TRP B 140 
AA6 1 2 O GLY B 223 ? O GLY B 223 N TRP B 148 ? N TRP B 148 
AA6 2 3 N LEU B 151 ? N LEU B 151 O TRP B 295 ? O TRP B 295 
AA6 3 4 O ALA B 298 ? O ALA B 298 N PHE B 194 ? N PHE B 194 
AA6 4 5 N VAL B 193 ? N VAL B 193 O GLN B 264 ? O GLN B 264 
AA7 1 2 N THR C 51  ? N THR C 51  O VAL C 214 ? O VAL C 214 
AA7 2 3 O MET C 208 ? O MET C 208 N LEU C 72  ? N LEU C 72  
AA8 1 2 N THR C 51  ? N THR C 51  O VAL C 214 ? O VAL C 214 
AA8 2 3 O PHE C 213 ? O PHE C 213 N THR C 117 ? N THR C 117 
AA8 3 4 N PHE C 116 ? N PHE C 116 O MET C 166 ? O MET C 166 
AA9 1 2 N LEU C 85  ? N LEU C 85  O ILE C 190 ? O ILE C 190 
AA9 2 3 O PHE C 193 ? O PHE C 193 N LEU C 131 ? N LEU C 131 
AA9 3 4 N LEU C 130 ? N LEU C 130 O TRP C 156 ? O TRP C 156 
AB1 1 2 O ARG C 177 ? O ARG C 177 N TRP C 110 ? N TRP C 110 
AB1 2 3 N ALA C 111 ? N ALA C 111 O SER C 221 ? O SER C 221 
# 
_pdbx_entry_details.entry_id                   9H93 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
_pdbx_validate_close_contact.id               1 
_pdbx_validate_close_contact.PDB_model_num    1 
_pdbx_validate_close_contact.auth_atom_id_1   OE1 
_pdbx_validate_close_contact.auth_asym_id_1   A 
_pdbx_validate_close_contact.auth_comp_id_1   GLU 
_pdbx_validate_close_contact.auth_seq_id_1    123 
_pdbx_validate_close_contact.PDB_ins_code_1   ? 
_pdbx_validate_close_contact.label_alt_id_1   ? 
_pdbx_validate_close_contact.auth_atom_id_2   OH 
_pdbx_validate_close_contact.auth_asym_id_2   A 
_pdbx_validate_close_contact.auth_comp_id_2   TYR 
_pdbx_validate_close_contact.auth_seq_id_2    279 
_pdbx_validate_close_contact.PDB_ins_code_2   ? 
_pdbx_validate_close_contact.label_alt_id_2   ? 
_pdbx_validate_close_contact.dist             2.16 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASN A 146 ? ? 47.43   26.88  
2 1 CYS A 270 ? ? 62.82   74.59  
3 1 ALA A 291 ? ? -112.60 72.16  
4 1 TYR B 104 ? ? 56.63   18.95  
5 1 SER B 251 ? ? -140.42 18.80  
6 1 SER B 311 ? ? -91.98  46.40  
7 1 SER B 312 ? ? -140.51 -12.36 
8 1 LEU C 224 ? ? 63.30   69.38  
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9H93 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   'Cross-correlation coefficient' 
_em_3d_fitting.details           
;Initial model was rigid body fitted using UCSF chimera and Coot.  Global minimization and B-factor refinement 
was performed in real space using phenix_real.space.refine.
;
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         REAL 
_em_3d_fitting.ref_protocol      'RIGID BODY FIT' 
# 
_em_3d_fitting_list.id                            1 
_em_3d_fitting_list.3d_fitting_id                 1 
_em_3d_fitting_list.pdb_entry_id                  1EAH 
_em_3d_fitting_list.pdb_chain_id                  ? 
_em_3d_fitting_list.pdb_chain_residue_range       ? 
_em_3d_fitting_list.details                       ? 
_em_3d_fitting_list.chain_id                      ? 
_em_3d_fitting_list.chain_residue_range           ? 
_em_3d_fitting_list.source_name                   PDB 
_em_3d_fitting_list.type                          'experimental model' 
_em_3d_fitting_list.accession_code                1EAH 
_em_3d_fitting_list.initial_refinement_model_id   1 
# 
_em_3d_reconstruction.entry_id                    9H93 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   'BACK PROJECTION' 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     
;Icosahedral symmetry applied to final reconstruction. Final maps were post-processed with an inverse B-factor of -86.1 Angstrom squared.
;
_em_3d_reconstruction.resolution                  2.4 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               113853 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          1 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       '1 x DPBS, 20 mM EDTA, pH 7.0' 
_em_buffer.pH            7.0 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 VIRUS 
_em_entity_assembly.name                 'Poliovirus 2' 
_em_entity_assembly.details              'Recombinantly expressed virus-like particle of poliovirus type 2 (MEF-1 strain).' 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       '1, 2, 3' 
# 
_em_image_scans.entry_id                9H93 
_em_image_scans.id                      1 
_em_image_scans.number_digital_images   ? 
_em_image_scans.details                 ? 
_em_image_scans.scanner_model           ? 
_em_image_scans.sampling_size           5.0 
_em_image_scans.od_range                ? 
_em_image_scans.quant_bit_size          ? 
_em_image_scans.citation_id             ? 
_em_image_scans.dimension_height        ? 
_em_image_scans.dimension_width         ? 
_em_image_scans.frames_per_image        30 
_em_image_scans.image_recording_id      1 
_em_image_scans.used_frames_per_image   1-30 
# 
_em_imaging.entry_id                        9H93 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'TFS KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           'FEI TITAN KRIOS AUTOGRID HOLDER' 
_em_imaging.details                         'Calibrated pixel size was 0.831 A/pixel.' 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'DARK FIELD' 
_em_imaging.nominal_cs                      2.7 
_em_imaging.nominal_defocus_min             800 
_em_imaging.nominal_defocus_max             2300 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           150000 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             'COMA FREE' 
_em_imaging.c2_aperture_diameter            100 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         NITROGEN 
# 
_em_sample_support.id               1 
_em_sample_support.film_material    ? 
_em_sample_support.method           ? 
_em_sample_support.grid_material    COPPER 
_em_sample_support.grid_mesh_size   200 
_em_sample_support.grid_type        'Quantifoil R2/1' 
_em_sample_support.details          ? 
_em_sample_support.specimen_id      1 
_em_sample_support.citation_id      ? 
# 
_em_virus_entity.id                    1 
_em_virus_entity.virus_host_category   ? 
_em_virus_entity.virus_type            'VIRUS-LIKE PARTICLE' 
_em_virus_entity.virus_isolate         SEROTYPE 
_em_virus_entity.entity_assembly_id    1 
_em_virus_entity.enveloped             NO 
_em_virus_entity.empty                 YES 
_em_virus_entity.details               ? 
# 
_em_vitrification.entry_id              9H93 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE-PROPANE 
_em_vitrification.humidity              100 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   277.15 
_em_vitrification.instrument            'FEI VITROBOT MARK IV' 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               '3ul of sample double blotted for 3.5 seconds with -15 blot force on FEI Vitrobot mark IV.' 
# 
_em_experiment.entry_id                9H93 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
_em_single_particle_entity.entry_id              9H93 
_em_single_particle_entity.id                    1 
_em_single_particle_entity.image_processing_id   1 
_em_single_particle_entity.point_symmetry        I 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A GLY 1   ? A GLY 1   
2   1 Y 1 A LEU 2   ? A LEU 2   
3   1 Y 1 A GLY 3   ? A GLY 3   
4   1 Y 1 A ASP 4   ? A ASP 4   
5   1 Y 1 A LEU 5   ? A LEU 5   
6   1 Y 1 A ILE 6   ? A ILE 6   
7   1 Y 1 A GLU 7   ? A GLU 7   
8   1 Y 1 A GLY 8   ? A GLY 8   
9   1 Y 1 A VAL 9   ? A VAL 9   
10  1 Y 1 A VAL 10  ? A VAL 10  
11  1 Y 1 A GLU 11  ? A GLU 11  
12  1 Y 1 A GLY 12  ? A GLY 12  
13  1 Y 1 A VAL 13  ? A VAL 13  
14  1 Y 1 A THR 14  ? A THR 14  
15  1 Y 1 A ARG 15  ? A ARG 15  
16  1 Y 1 A ASN 16  ? A ASN 16  
17  1 Y 1 A ALA 17  ? A ALA 17  
18  1 Y 1 A LEU 18  ? A LEU 18  
19  1 Y 1 A THR 19  ? A THR 19  
20  1 Y 1 A PRO 20  ? A PRO 20  
21  1 Y 1 A LEU 21  ? A LEU 21  
22  1 Y 1 A THR 22  ? A THR 22  
23  1 Y 1 A PRO 23  ? A PRO 23  
24  1 Y 1 A ALA 24  ? A ALA 24  
25  1 Y 1 A ASN 25  ? A ASN 25  
26  1 Y 1 A ASN 26  ? A ASN 26  
27  1 Y 1 A LEU 27  ? A LEU 27  
28  1 Y 1 A PRO 28  ? A PRO 28  
29  1 Y 1 A ASP 29  ? A ASP 29  
30  1 Y 1 A THR 30  ? A THR 30  
31  1 Y 1 A GLN 31  ? A GLN 31  
32  1 Y 1 A SER 32  ? A SER 32  
33  1 Y 1 A SER 33  ? A SER 33  
34  1 Y 1 A GLY 34  ? A GLY 34  
35  1 Y 1 A PRO 35  ? A PRO 35  
36  1 Y 1 A ALA 36  ? A ALA 36  
37  1 Y 1 A HIS 37  ? A HIS 37  
38  1 Y 1 A SER 38  ? A SER 38  
39  1 Y 1 A LYS 39  ? A LYS 39  
40  1 Y 1 A GLU 40  ? A GLU 40  
41  1 Y 1 A THR 41  ? A THR 41  
42  1 Y 1 A PRO 42  ? A PRO 42  
43  1 Y 1 A ALA 43  ? A ALA 43  
44  1 Y 1 A LEU 44  ? A LEU 44  
45  1 Y 1 A THR 45  ? A THR 45  
46  1 Y 1 A ALA 46  ? A ALA 46  
47  1 Y 1 A VAL 47  ? A VAL 47  
48  1 Y 1 A GLU 48  ? A GLU 48  
49  1 Y 1 A THR 49  ? A THR 49  
50  1 Y 1 A GLY 50  ? A GLY 50  
51  1 Y 1 A ALA 51  ? A ALA 51  
52  1 Y 1 A THR 52  ? A THR 52  
53  1 Y 1 A ASN 53  ? A ASN 53  
54  1 Y 1 A PRO 54  ? A PRO 54  
55  1 Y 1 A LEU 55  ? A LEU 55  
56  1 Y 1 A VAL 56  ? A VAL 56  
57  1 Y 1 A PRO 57  ? A PRO 57  
58  1 Y 1 A SER 58  ? A SER 58  
59  1 Y 1 A ASP 59  ? A ASP 59  
60  1 Y 1 A THR 60  ? A THR 60  
61  1 Y 1 A VAL 61  ? A VAL 61  
62  1 Y 1 A GLN 62  ? A GLN 62  
63  1 Y 1 A THR 63  ? A THR 63  
64  1 Y 1 A ARG 64  ? A ARG 64  
65  1 Y 1 A HIS 65  ? A HIS 65  
66  1 Y 1 A VAL 66  ? A VAL 66  
67  1 Y 1 A ILE 67  ? A ILE 67  
68  1 Y 1 A GLN 68  ? A GLN 68  
69  1 Y 1 A LYS 69  ? A LYS 69  
70  1 Y 1 A THR 98  ? A THR 98  
71  1 Y 1 A LYS 99  ? A LYS 99  
72  1 Y 1 A ARG 100 ? A ARG 100 
73  1 Y 1 A THR 223 ? A THR 223 
74  1 Y 1 A GLU 224 ? A GLU 224 
75  1 Y 1 B MET 1   ? B MET 1   
76  1 Y 1 B GLY 2   ? B GLY 2   
77  1 Y 1 B ALA 3   ? B ALA 3   
78  1 Y 1 B GLN 4   ? B GLN 4   
79  1 Y 1 B VAL 5   ? B VAL 5   
80  1 Y 1 B SER 6   ? B SER 6   
81  1 Y 1 B SER 7   ? B SER 7   
82  1 Y 1 B GLN 8   ? B GLN 8   
83  1 Y 1 B LYS 9   ? B LYS 9   
84  1 Y 1 B VAL 10  ? B VAL 10  
85  1 Y 1 B GLY 11  ? B GLY 11  
86  1 Y 1 B ALA 12  ? B ALA 12  
87  1 Y 1 B HIS 13  ? B HIS 13  
88  1 Y 1 B GLU 14  ? B GLU 14  
89  1 Y 1 B ASN 15  ? B ASN 15  
90  1 Y 1 B SER 16  ? B SER 16  
91  1 Y 1 B ASN 17  ? B ASN 17  
92  1 Y 1 B ARG 18  ? B ARG 18  
93  1 Y 1 B ALA 19  ? B ALA 19  
94  1 Y 1 B TYR 20  ? B TYR 20  
95  1 Y 1 B GLY 21  ? B GLY 21  
96  1 Y 1 B GLY 22  ? B GLY 22  
97  1 Y 1 B SER 23  ? B SER 23  
98  1 Y 1 B THR 24  ? B THR 24  
99  1 Y 1 B ILE 25  ? B ILE 25  
100 1 Y 1 B ASN 26  ? B ASN 26  
101 1 Y 1 B TYR 27  ? B TYR 27  
102 1 Y 1 B THR 28  ? B THR 28  
103 1 Y 1 B THR 29  ? B THR 29  
104 1 Y 1 B ILE 30  ? B ILE 30  
105 1 Y 1 B ASN 31  ? B ASN 31  
106 1 Y 1 B TYR 32  ? B TYR 32  
107 1 Y 1 B TYR 33  ? B TYR 33  
108 1 Y 1 B ARG 34  ? B ARG 34  
109 1 Y 1 B ASP 35  ? B ASP 35  
110 1 Y 1 B SER 36  ? B SER 36  
111 1 Y 1 B ALA 37  ? B ALA 37  
112 1 Y 1 B SER 38  ? B SER 38  
113 1 Y 1 B ASN 39  ? B ASN 39  
114 1 Y 1 B ALA 40  ? B ALA 40  
115 1 Y 1 B ALA 41  ? B ALA 41  
116 1 Y 1 B SER 42  ? B SER 42  
117 1 Y 1 B LYS 43  ? B LYS 43  
118 1 Y 1 B GLN 44  ? B GLN 44  
119 1 Y 1 B ASP 45  ? B ASP 45  
120 1 Y 1 B PHE 46  ? B PHE 46  
121 1 Y 1 B ALA 47  ? B ALA 47  
122 1 Y 1 B GLN 48  ? B GLN 48  
123 1 Y 1 B ASP 49  ? B ASP 49  
124 1 Y 1 B PRO 50  ? B PRO 50  
125 1 Y 1 B SER 51  ? B SER 51  
126 1 Y 1 B LYS 52  ? B LYS 52  
127 1 Y 1 B PHE 53  ? B PHE 53  
128 1 Y 1 B THR 54  ? B THR 54  
129 1 Y 1 B GLU 55  ? B GLU 55  
130 1 Y 1 B PRO 56  ? B PRO 56  
131 1 Y 1 B VAL 57  ? B VAL 57  
132 1 Y 1 B LYS 58  ? B LYS 58  
133 1 Y 1 B ASP 59  ? B ASP 59  
134 1 Y 1 B VAL 60  ? B VAL 60  
135 1 Y 1 B LEU 61  ? B LEU 61  
136 1 Y 1 B ILE 62  ? B ILE 62  
137 1 Y 1 B LYS 63  ? B LYS 63  
138 1 Y 1 B THR 64  ? B THR 64  
139 1 Y 1 B ALA 65  ? B ALA 65  
140 1 Y 1 B PRO 66  ? B PRO 66  
141 1 Y 1 B THR 67  ? B THR 67  
142 1 Y 1 B LEU 68  ? B LEU 68  
143 1 Y 1 B ASN 69  ? B ASN 69  
144 1 Y 1 B SER 70  ? B SER 70  
145 1 Y 1 B PRO 71  ? B PRO 71  
146 1 Y 1 B ASN 72  ? B ASN 72  
147 1 Y 1 B ILE 73  ? B ILE 73  
148 1 Y 1 B GLU 74  ? B GLU 74  
149 1 Y 1 B ALA 75  ? B ALA 75  
150 1 Y 1 B CYS 76  ? B CYS 76  
151 1 Y 1 B GLY 77  ? B GLY 77  
152 1 Y 1 B TYR 78  ? B TYR 78  
153 1 Y 1 B SER 79  ? B SER 79  
154 1 Y 1 B ASP 80  ? B ASP 80  
155 1 Y 1 B ARG 81  ? B ARG 81  
156 1 Y 1 B VAL 82  ? B VAL 82  
157 1 Y 1 B MET 83  ? B MET 83  
158 1 Y 1 B GLN 84  ? B GLN 84  
159 1 Y 1 B LEU 85  ? B LEU 85  
160 1 Y 1 B THR 93  ? B THR 93  
161 1 Y 1 B THR 94  ? B THR 94  
162 1 Y 1 B GLN 95  ? B GLN 95  
163 1 Y 1 B GLU 96  ? B GLU 96  
164 1 Y 1 B ALA 97  ? B ALA 97  
165 1 Y 1 B ALA 98  ? B ALA 98  
166 1 Y 1 B LYS 112 ? B LYS 112 
167 1 Y 1 B ASP 113 ? B ASP 113 
168 1 Y 1 B SER 114 ? B SER 114 
169 1 Y 1 B GLU 115 ? B GLU 115 
170 1 Y 1 B ALA 116 ? B ALA 116 
171 1 Y 1 B ASN 117 ? B ASN 117 
172 1 Y 1 B PRO 118 ? B PRO 118 
173 1 Y 1 B VAL 119 ? B VAL 119 
174 1 Y 1 B ASP 120 ? B ASP 120 
175 1 Y 1 B GLN 121 ? B GLN 121 
176 1 Y 1 B PRO 122 ? B PRO 122 
177 1 Y 1 B THR 123 ? B THR 123 
178 1 Y 1 B GLU 124 ? B GLU 124 
179 1 Y 1 B PRO 125 ? B PRO 125 
180 1 Y 1 C ALA 235 ? C ALA 235 
181 1 Y 1 C MET 236 ? C MET 236 
182 1 Y 1 C PRO 237 ? C PRO 237 
183 1 Y 1 C GLN 238 ? C GLN 238 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
PHE N    N N N 247 
PHE CA   C N S 248 
PHE C    C N N 249 
PHE O    O N N 250 
PHE CB   C N N 251 
PHE CG   C Y N 252 
PHE CD1  C Y N 253 
PHE CD2  C Y N 254 
PHE CE1  C Y N 255 
PHE CE2  C Y N 256 
PHE CZ   C Y N 257 
PHE OXT  O N N 258 
PHE H    H N N 259 
PHE H2   H N N 260 
PHE HA   H N N 261 
PHE HB2  H N N 262 
PHE HB3  H N N 263 
PHE HD1  H N N 264 
PHE HD2  H N N 265 
PHE HE1  H N N 266 
PHE HE2  H N N 267 
PHE HZ   H N N 268 
PHE HXT  H N N 269 
PRO N    N N N 270 
PRO CA   C N S 271 
PRO C    C N N 272 
PRO O    O N N 273 
PRO CB   C N N 274 
PRO CG   C N N 275 
PRO CD   C N N 276 
PRO OXT  O N N 277 
PRO H    H N N 278 
PRO HA   H N N 279 
PRO HB2  H N N 280 
PRO HB3  H N N 281 
PRO HG2  H N N 282 
PRO HG3  H N N 283 
PRO HD2  H N N 284 
PRO HD3  H N N 285 
PRO HXT  H N N 286 
SER N    N N N 287 
SER CA   C N S 288 
SER C    C N N 289 
SER O    O N N 290 
SER CB   C N N 291 
SER OG   O N N 292 
SER OXT  O N N 293 
SER H    H N N 294 
SER H2   H N N 295 
SER HA   H N N 296 
SER HB2  H N N 297 
SER HB3  H N N 298 
SER HG   H N N 299 
SER HXT  H N N 300 
SPH C1   C N N 301 
SPH O1   O N N 302 
SPH C2   C N R 303 
SPH N2   N N N 304 
SPH C3   C N S 305 
SPH O3   O N N 306 
SPH C4   C N N 307 
SPH C5   C N N 308 
SPH C6   C N N 309 
SPH C7   C N N 310 
SPH C8   C N N 311 
SPH C9   C N N 312 
SPH C10  C N N 313 
SPH C11  C N N 314 
SPH C12  C N N 315 
SPH C13  C N N 316 
SPH C14  C N N 317 
SPH C15  C N N 318 
SPH C16  C N N 319 
SPH C17  C N N 320 
SPH C18  C N N 321 
SPH H11  H N N 322 
SPH H12  H N N 323 
SPH HO1  H N N 324 
SPH H2   H N N 325 
SPH HN21 H N N 326 
SPH HN22 H N N 327 
SPH H3   H N N 328 
SPH HO3  H N N 329 
SPH H4   H N N 330 
SPH H5   H N N 331 
SPH H61  H N N 332 
SPH H62  H N N 333 
SPH H71  H N N 334 
SPH H72  H N N 335 
SPH H81  H N N 336 
SPH H82  H N N 337 
SPH H91  H N N 338 
SPH H92  H N N 339 
SPH H101 H N N 340 
SPH H102 H N N 341 
SPH H111 H N N 342 
SPH H112 H N N 343 
SPH H121 H N N 344 
SPH H122 H N N 345 
SPH H131 H N N 346 
SPH H132 H N N 347 
SPH H141 H N N 348 
SPH H142 H N N 349 
SPH H151 H N N 350 
SPH H152 H N N 351 
SPH H161 H N N 352 
SPH H162 H N N 353 
SPH H171 H N N 354 
SPH H172 H N N 355 
SPH H181 H N N 356 
SPH H182 H N N 357 
SPH H183 H N N 358 
THR N    N N N 359 
THR CA   C N S 360 
THR C    C N N 361 
THR O    O N N 362 
THR CB   C N R 363 
THR OG1  O N N 364 
THR CG2  C N N 365 
THR OXT  O N N 366 
THR H    H N N 367 
THR H2   H N N 368 
THR HA   H N N 369 
THR HB   H N N 370 
THR HG1  H N N 371 
THR HG21 H N N 372 
THR HG22 H N N 373 
THR HG23 H N N 374 
THR HXT  H N N 375 
TRP N    N N N 376 
TRP CA   C N S 377 
TRP C    C N N 378 
TRP O    O N N 379 
TRP CB   C N N 380 
TRP CG   C Y N 381 
TRP CD1  C Y N 382 
TRP CD2  C Y N 383 
TRP NE1  N Y N 384 
TRP CE2  C Y N 385 
TRP CE3  C Y N 386 
TRP CZ2  C Y N 387 
TRP CZ3  C Y N 388 
TRP CH2  C Y N 389 
TRP OXT  O N N 390 
TRP H    H N N 391 
TRP H2   H N N 392 
TRP HA   H N N 393 
TRP HB2  H N N 394 
TRP HB3  H N N 395 
TRP HD1  H N N 396 
TRP HE1  H N N 397 
TRP HE3  H N N 398 
TRP HZ2  H N N 399 
TRP HZ3  H N N 400 
TRP HH2  H N N 401 
TRP HXT  H N N 402 
TYR N    N N N 403 
TYR CA   C N S 404 
TYR C    C N N 405 
TYR O    O N N 406 
TYR CB   C N N 407 
TYR CG   C Y N 408 
TYR CD1  C Y N 409 
TYR CD2  C Y N 410 
TYR CE1  C Y N 411 
TYR CE2  C Y N 412 
TYR CZ   C Y N 413 
TYR OH   O N N 414 
TYR OXT  O N N 415 
TYR H    H N N 416 
TYR H2   H N N 417 
TYR HA   H N N 418 
TYR HB2  H N N 419 
TYR HB3  H N N 420 
TYR HD1  H N N 421 
TYR HD2  H N N 422 
TYR HE1  H N N 423 
TYR HE2  H N N 424 
TYR HH   H N N 425 
TYR HXT  H N N 426 
VAL N    N N N 427 
VAL CA   C N S 428 
VAL C    C N N 429 
VAL O    O N N 430 
VAL CB   C N N 431 
VAL CG1  C N N 432 
VAL CG2  C N N 433 
VAL OXT  O N N 434 
VAL H    H N N 435 
VAL H2   H N N 436 
VAL HA   H N N 437 
VAL HB   H N N 438 
VAL HG11 H N N 439 
VAL HG12 H N N 440 
VAL HG13 H N N 441 
VAL HG21 H N N 442 
VAL HG22 H N N 443 
VAL HG23 H N N 444 
VAL HXT  H N N 445 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
PHE N   CA   sing N N 235 
PHE N   H    sing N N 236 
PHE N   H2   sing N N 237 
PHE CA  C    sing N N 238 
PHE CA  CB   sing N N 239 
PHE CA  HA   sing N N 240 
PHE C   O    doub N N 241 
PHE C   OXT  sing N N 242 
PHE CB  CG   sing N N 243 
PHE CB  HB2  sing N N 244 
PHE CB  HB3  sing N N 245 
PHE CG  CD1  doub Y N 246 
PHE CG  CD2  sing Y N 247 
PHE CD1 CE1  sing Y N 248 
PHE CD1 HD1  sing N N 249 
PHE CD2 CE2  doub Y N 250 
PHE CD2 HD2  sing N N 251 
PHE CE1 CZ   doub Y N 252 
PHE CE1 HE1  sing N N 253 
PHE CE2 CZ   sing Y N 254 
PHE CE2 HE2  sing N N 255 
PHE CZ  HZ   sing N N 256 
PHE OXT HXT  sing N N 257 
PRO N   CA   sing N N 258 
PRO N   CD   sing N N 259 
PRO N   H    sing N N 260 
PRO CA  C    sing N N 261 
PRO CA  CB   sing N N 262 
PRO CA  HA   sing N N 263 
PRO C   O    doub N N 264 
PRO C   OXT  sing N N 265 
PRO CB  CG   sing N N 266 
PRO CB  HB2  sing N N 267 
PRO CB  HB3  sing N N 268 
PRO CG  CD   sing N N 269 
PRO CG  HG2  sing N N 270 
PRO CG  HG3  sing N N 271 
PRO CD  HD2  sing N N 272 
PRO CD  HD3  sing N N 273 
PRO OXT HXT  sing N N 274 
SER N   CA   sing N N 275 
SER N   H    sing N N 276 
SER N   H2   sing N N 277 
SER CA  C    sing N N 278 
SER CA  CB   sing N N 279 
SER CA  HA   sing N N 280 
SER C   O    doub N N 281 
SER C   OXT  sing N N 282 
SER CB  OG   sing N N 283 
SER CB  HB2  sing N N 284 
SER CB  HB3  sing N N 285 
SER OG  HG   sing N N 286 
SER OXT HXT  sing N N 287 
SPH C1  O1   sing N N 288 
SPH C1  C2   sing N N 289 
SPH C1  H11  sing N N 290 
SPH C1  H12  sing N N 291 
SPH O1  HO1  sing N N 292 
SPH C2  N2   sing N N 293 
SPH C2  C3   sing N N 294 
SPH C2  H2   sing N N 295 
SPH N2  HN21 sing N N 296 
SPH N2  HN22 sing N N 297 
SPH C3  O3   sing N N 298 
SPH C3  C4   sing N N 299 
SPH C3  H3   sing N N 300 
SPH O3  HO3  sing N N 301 
SPH C4  C5   doub N Z 302 
SPH C4  H4   sing N N 303 
SPH C5  C6   sing N N 304 
SPH C5  H5   sing N N 305 
SPH C6  C7   sing N N 306 
SPH C6  H61  sing N N 307 
SPH C6  H62  sing N N 308 
SPH C7  C8   sing N N 309 
SPH C7  H71  sing N N 310 
SPH C7  H72  sing N N 311 
SPH C8  C9   sing N N 312 
SPH C8  H81  sing N N 313 
SPH C8  H82  sing N N 314 
SPH C9  C10  sing N N 315 
SPH C9  H91  sing N N 316 
SPH C9  H92  sing N N 317 
SPH C10 C11  sing N N 318 
SPH C10 H101 sing N N 319 
SPH C10 H102 sing N N 320 
SPH C11 C12  sing N N 321 
SPH C11 H111 sing N N 322 
SPH C11 H112 sing N N 323 
SPH C12 C13  sing N N 324 
SPH C12 H121 sing N N 325 
SPH C12 H122 sing N N 326 
SPH C13 C14  sing N N 327 
SPH C13 H131 sing N N 328 
SPH C13 H132 sing N N 329 
SPH C14 C15  sing N N 330 
SPH C14 H141 sing N N 331 
SPH C14 H142 sing N N 332 
SPH C15 C16  sing N N 333 
SPH C15 H151 sing N N 334 
SPH C15 H152 sing N N 335 
SPH C16 C17  sing N N 336 
SPH C16 H161 sing N N 337 
SPH C16 H162 sing N N 338 
SPH C17 C18  sing N N 339 
SPH C17 H171 sing N N 340 
SPH C17 H172 sing N N 341 
SPH C18 H181 sing N N 342 
SPH C18 H182 sing N N 343 
SPH C18 H183 sing N N 344 
THR N   CA   sing N N 345 
THR N   H    sing N N 346 
THR N   H2   sing N N 347 
THR CA  C    sing N N 348 
THR CA  CB   sing N N 349 
THR CA  HA   sing N N 350 
THR C   O    doub N N 351 
THR C   OXT  sing N N 352 
THR CB  OG1  sing N N 353 
THR CB  CG2  sing N N 354 
THR CB  HB   sing N N 355 
THR OG1 HG1  sing N N 356 
THR CG2 HG21 sing N N 357 
THR CG2 HG22 sing N N 358 
THR CG2 HG23 sing N N 359 
THR OXT HXT  sing N N 360 
TRP N   CA   sing N N 361 
TRP N   H    sing N N 362 
TRP N   H2   sing N N 363 
TRP CA  C    sing N N 364 
TRP CA  CB   sing N N 365 
TRP CA  HA   sing N N 366 
TRP C   O    doub N N 367 
TRP C   OXT  sing N N 368 
TRP CB  CG   sing N N 369 
TRP CB  HB2  sing N N 370 
TRP CB  HB3  sing N N 371 
TRP CG  CD1  doub Y N 372 
TRP CG  CD2  sing Y N 373 
TRP CD1 NE1  sing Y N 374 
TRP CD1 HD1  sing N N 375 
TRP CD2 CE2  doub Y N 376 
TRP CD2 CE3  sing Y N 377 
TRP NE1 CE2  sing Y N 378 
TRP NE1 HE1  sing N N 379 
TRP CE2 CZ2  sing Y N 380 
TRP CE3 CZ3  doub Y N 381 
TRP CE3 HE3  sing N N 382 
TRP CZ2 CH2  doub Y N 383 
TRP CZ2 HZ2  sing N N 384 
TRP CZ3 CH2  sing Y N 385 
TRP CZ3 HZ3  sing N N 386 
TRP CH2 HH2  sing N N 387 
TRP OXT HXT  sing N N 388 
TYR N   CA   sing N N 389 
TYR N   H    sing N N 390 
TYR N   H2   sing N N 391 
TYR CA  C    sing N N 392 
TYR CA  CB   sing N N 393 
TYR CA  HA   sing N N 394 
TYR C   O    doub N N 395 
TYR C   OXT  sing N N 396 
TYR CB  CG   sing N N 397 
TYR CB  HB2  sing N N 398 
TYR CB  HB3  sing N N 399 
TYR CG  CD1  doub Y N 400 
TYR CG  CD2  sing Y N 401 
TYR CD1 CE1  sing Y N 402 
TYR CD1 HD1  sing N N 403 
TYR CD2 CE2  doub Y N 404 
TYR CD2 HD2  sing N N 405 
TYR CE1 CZ   doub Y N 406 
TYR CE1 HE1  sing N N 407 
TYR CE2 CZ   sing Y N 408 
TYR CE2 HE2  sing N N 409 
TYR CZ  OH   sing N N 410 
TYR OH  HH   sing N N 411 
TYR OXT HXT  sing N N 412 
VAL N   CA   sing N N 413 
VAL N   H    sing N N 414 
VAL N   H2   sing N N 415 
VAL CA  C    sing N N 416 
VAL CA  CB   sing N N 417 
VAL CA  HA   sing N N 418 
VAL C   O    doub N N 419 
VAL C   OXT  sing N N 420 
VAL CB  CG1  sing N N 421 
VAL CB  CG2  sing N N 422 
VAL CB  HB   sing N N 423 
VAL CG1 HG11 sing N N 424 
VAL CG1 HG12 sing N N 425 
VAL CG1 HG13 sing N N 426 
VAL CG2 HG21 sing N N 427 
VAL CG2 HG22 sing N N 428 
VAL CG2 HG23 sing N N 429 
VAL OXT HXT  sing N N 430 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-10-29 
_em_admin.deposition_site    PDBE 
_em_admin.entry_id           9H93 
_em_admin.last_update        2025-04-09 
_em_admin.map_release_date   2025-04-02 
_em_admin.title              
'Poliovirus type 2 (strain MEF-1) stabilised virus-like particle (PV2 SC6b) from a yeast expression system.' 
# 
loop_
_em_buffer_component.buffer_id 
_em_buffer_component.concentration 
_em_buffer_component.concentration_units 
_em_buffer_component.formula 
_em_buffer_component.id 
_em_buffer_component.name 
1 1  x  ? 1 DPBS 
1 20 mM ? 2 EDTA 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_molwt.entity_assembly_id   1 
_em_entity_assembly_molwt.experimental_flag    NO 
_em_entity_assembly_molwt.id                   1 
_em_entity_assembly_molwt.units                MEGADALTONS 
_em_entity_assembly_molwt.value                5.81 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          12083 
_em_entity_assembly_naturalsource.organism             'Poliovirus 2' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               MEF-1 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          4922 
_em_entity_assembly_recombinant.organism             'Komagataella pastoris' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               1.6 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         35.12 
_em_image_recording.details                             'Pixel sampling was 0.831 A/pixel. Energy filter was Gatan GIF Quantum.' 
_em_image_recording.detector_mode                       COUNTING 
_em_image_recording.film_or_detector_model              'GATAN K3 BIOQUANTUM (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    1 
_em_image_recording.num_real_images                     29172 
# 
_em_imaging_optics.chr_aberration_corrector   ? 
_em_imaging_optics.energyfilter_lower         ? 
_em_imaging_optics.energyfilter_slit_width    20 
_em_imaging_optics.energyfilter_name          'GIF Bioquantum' 
_em_imaging_optics.energyfilter_upper         ? 
_em_imaging_optics.id                         1 
_em_imaging_optics.imaging_id                 1 
_em_imaging_optics.phase_plate                ? 
_em_imaging_optics.sph_aberration_corrector   ? 
_em_imaging_optics.details                    ? 
# 
_em_particle_selection.details                  ? 
_em_particle_selection.id                       1 
_em_particle_selection.image_processing_id      1 
_em_particle_selection.method                   ? 
_em_particle_selection.num_particles_selected   660747 
_em_particle_selection.reference_model          ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'            'Template picker'            1  1 ? ? cryoSPARC      4.5.3           
'IMAGE ACQUISITION'             ?                            2  1 ? 1 EPU            ?               
MASKING                         ?                            3  1 1 1 ?              ?               
'CTF CORRECTION'                'Patch CTF'                  4  1 ? ? cryoSPARC      4.5.3           
'LAYERLINE INDEXING'            ?                            5  1 1 1 ?              ?               
'DIFFRACTION INDEXING'          ?                            6  1 1 1 ?              ?               
'MODEL FITTING'                 ?                            7  1 1 ? 'UCSF Chimera' 1.16            
'MODEL FITTING'                 ?                            8  ? 1 ? Coot           0.9.6           
OTHER                           ?                            9  1 1 1 ?              ?               
'INITIAL EULER ASSIGNMENT'      'ab initio reconstruction'   10 1 ? ? cryoSPARC      4.5.3           
'FINAL EULER ASSIGNMENT'        'Homogeneous reconstruction' 11 1 ? ? cryoSPARC      4.5.3           
CLASSIFICATION                  'Heterogeneous refinement'   12 1 ? ? cryoSPARC      4.5.3           
RECONSTRUCTION                  'Homogeneous reconstruction' 13 1 ? ? cryoSPARC      4.5.3           
'MODEL REFINEMENT'              ?                            14 ? 1 ? PHENIX         1.20.1-4487-000 
'VOLUME SELECTION'              ?                            15 1 1 1 ?              ?               
'SERIES ALIGNMENT'              ?                            16 1 1 1 ?              ?               
'MOLECULAR REPLACEMENT'         ?                            17 1 1 1 ?              ?               
'LATTICE DISTORTION CORRECTION' ?                            18 1 1 1 ?              ?               
'SYMMETRY DETERMINATION'        ?                            19 1 1 1 ?              ?               
'CRYSTALLOGRAPHY MERGING'       ?                            20 1 1 1 ?              ?               
# 
_em_specimen.concentration           0.1 
_em_specimen.details                 'Sample purified by sucrose density gradient ultracentrifugation.' 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_em_virus_natural_host.entity_assembly_id   1 
_em_virus_natural_host.id                   1 
_em_virus_natural_host.ncbi_tax_id          9606 
_em_virus_natural_host.organism             'Homo sapiens' 
_em_virus_natural_host.strain               ? 
# 
_em_virus_shell.diameter             310 
_em_virus_shell.entity_assembly_id   1 
_em_virus_shell.id                   1 
_em_virus_shell.name                 'Virus shell 1' 
_em_virus_shell.triangulation        1 
# 
_pdbx_audit_support.funding_organization   'Bill & Melinda Gates Foundation' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           RG.IMCB.I8-TSA-083 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   1EAH 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9H93 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . ARG A 1 70  ? 207.703 279.881 342.148 1.00 37.85 ? 70  ARG A N   1 
ATOM   2    C CA  . ARG A 1 70  ? 208.328 280.283 343.402 1.00 35.01 ? 70  ARG A CA  1 
ATOM   3    C C   . ARG A 1 70  ? 209.543 279.413 343.702 1.00 35.93 ? 70  ARG A C   1 
ATOM   4    O O   . ARG A 1 70  ? 209.412 278.237 344.034 1.00 37.47 ? 70  ARG A O   1 
ATOM   5    C CB  . ARG A 1 70  ? 207.322 280.205 344.552 1.00 36.42 ? 70  ARG A CB  1 
ATOM   6    C CG  . ARG A 1 70  ? 206.243 281.273 344.499 1.00 33.65 ? 70  ARG A CG  1 
ATOM   7    C CD  . ARG A 1 70  ? 205.308 281.205 345.696 1.00 34.71 ? 70  ARG A CD  1 
ATOM   8    N NE  . ARG A 1 70  ? 204.491 279.996 345.696 1.00 39.84 ? 70  ARG A NE  1 
ATOM   9    C CZ  . ARG A 1 70  ? 204.795 278.874 346.334 1.00 39.79 ? 70  ARG A CZ  1 
ATOM   10   N NH1 . ARG A 1 70  ? 205.905 278.757 347.046 1.00 37.19 ? 70  ARG A NH1 1 
ATOM   11   N NH2 . ARG A 1 70  ? 203.962 277.840 346.259 1.00 37.79 ? 70  ARG A NH2 1 
ATOM   12   N N   . THR A 1 71  ? 210.727 280.002 343.576 1.00 31.96 ? 71  THR A N   1 
ATOM   13   C CA  . THR A 1 71  ? 211.973 279.298 343.827 1.00 28.21 ? 71  THR A CA  1 
ATOM   14   C C   . THR A 1 71  ? 212.348 279.404 345.303 1.00 30.28 ? 71  THR A C   1 
ATOM   15   O O   . THR A 1 71  ? 211.781 280.190 346.063 1.00 28.89 ? 71  THR A O   1 
ATOM   16   C CB  . THR A 1 71  ? 213.094 279.858 342.946 1.00 32.45 ? 71  THR A CB  1 
ATOM   17   O OG1 . THR A 1 71  ? 214.204 278.952 342.943 1.00 34.89 ? 71  THR A OG1 1 
ATOM   18   C CG2 . THR A 1 71  ? 213.560 281.208 343.462 1.00 27.59 ? 71  THR A CG2 1 
ATOM   19   N N   . ARG A 1 72  ? 213.323 278.592 345.703 1.00 25.91 ? 72  ARG A N   1 
ATOM   20   C CA  . ARG A 1 72  ? 213.797 278.523 347.080 1.00 20.71 ? 72  ARG A CA  1 
ATOM   21   C C   . ARG A 1 72  ? 215.200 279.105 347.213 1.00 19.50 ? 72  ARG A C   1 
ATOM   22   O O   . ARG A 1 72  ? 216.047 278.571 347.930 1.00 26.77 ? 72  ARG A O   1 
ATOM   23   C CB  . ARG A 1 72  ? 213.761 277.083 347.580 1.00 23.09 ? 72  ARG A CB  1 
ATOM   24   C CG  . ARG A 1 72  ? 212.358 276.535 347.740 1.00 19.18 ? 72  ARG A CG  1 
ATOM   25   C CD  . ARG A 1 72  ? 212.361 275.050 348.004 1.00 22.38 ? 72  ARG A CD  1 
ATOM   26   N NE  . ARG A 1 72  ? 211.050 274.580 348.432 1.00 26.06 ? 72  ARG A NE  1 
ATOM   27   C CZ  . ARG A 1 72  ? 210.771 273.328 348.761 1.00 18.87 ? 72  ARG A CZ  1 
ATOM   28   N NH1 . ARG A 1 72  ? 211.684 272.376 348.697 1.00 23.18 ? 72  ARG A NH1 1 
ATOM   29   N NH2 . ARG A 1 72  ? 209.543 273.024 349.167 1.00 21.52 ? 72  ARG A NH2 1 
ATOM   30   N N   . SER A 1 73  ? 215.456 280.217 346.519 1.00 27.06 ? 73  SER A N   1 
ATOM   31   C CA  . SER A 1 73  ? 216.806 280.769 346.469 1.00 17.62 ? 73  SER A CA  1 
ATOM   32   C C   . SER A 1 73  ? 217.232 281.332 347.819 1.00 16.17 ? 73  SER A C   1 
ATOM   33   O O   . SER A 1 73  ? 218.407 281.247 348.189 1.00 23.88 ? 73  SER A O   1 
ATOM   34   C CB  . SER A 1 73  ? 216.890 281.848 345.389 1.00 20.09 ? 73  SER A CB  1 
ATOM   35   O OG  . SER A 1 73  ? 216.059 282.951 345.696 1.00 26.25 ? 73  SER A OG  1 
ATOM   36   N N   . GLU A 1 74  ? 216.300 281.910 348.568 1.00 14.75 ? 74  GLU A N   1 
ATOM   37   C CA  . GLU A 1 74  ? 216.641 282.540 349.834 1.00 18.13 ? 74  GLU A CA  1 
ATOM   38   C C   . GLU A 1 74  ? 216.636 281.569 351.007 1.00 21.16 ? 74  GLU A C   1 
ATOM   39   O O   . GLU A 1 74  ? 217.019 281.961 352.113 1.00 26.14 ? 74  GLU A O   1 
ATOM   40   C CB  . GLU A 1 74  ? 215.680 283.696 350.124 1.00 23.89 ? 74  GLU A CB  1 
ATOM   41   C CG  . GLU A 1 74  ? 216.213 284.689 351.141 1.00 24.38 ? 74  GLU A CG  1 
ATOM   42   C CD  . GLU A 1 74  ? 215.331 285.906 351.300 1.00 26.58 ? 74  GLU A CD  1 
ATOM   43   O OE1 . GLU A 1 74  ? 214.365 286.053 350.524 1.00 30.56 ? 74  GLU A OE1 1 
ATOM   44   O OE2 . GLU A 1 74  ? 215.602 286.716 352.208 1.00 25.12 ? 74  GLU A OE2 1 
ATOM   45   N N   . SER A 1 75  ? 216.221 280.322 350.802 1.00 23.33 ? 75  SER A N   1 
ATOM   46   C CA  . SER A 1 75  ? 216.284 279.308 351.844 1.00 17.39 ? 75  SER A CA  1 
ATOM   47   C C   . SER A 1 75  ? 217.426 278.321 351.643 1.00 15.30 ? 75  SER A C   1 
ATOM   48   O O   . SER A 1 75  ? 217.545 277.372 352.421 1.00 23.45 ? 75  SER A O   1 
ATOM   49   C CB  . SER A 1 75  ? 214.953 278.554 351.938 1.00 13.22 ? 75  SER A CB  1 
ATOM   50   O OG  . SER A 1 75  ? 214.554 278.043 350.682 1.00 25.71 ? 75  SER A OG  1 
ATOM   51   N N   . THR A 1 76  ? 218.273 278.518 350.637 1.00 14.49 ? 76  THR A N   1 
ATOM   52   C CA  . THR A 1 76  ? 219.472 277.705 350.541 1.00 11.05 ? 76  THR A CA  1 
ATOM   53   C C   . THR A 1 76  ? 220.330 277.919 351.782 1.00 16.84 ? 76  THR A C   1 
ATOM   54   O O   . THR A 1 76  ? 220.232 278.937 352.471 1.00 27.47 ? 76  THR A O   1 
ATOM   55   C CB  . THR A 1 76  ? 220.280 278.046 349.286 1.00 9.43  ? 76  THR A CB  1 
ATOM   56   O OG1 . THR A 1 76  ? 220.778 279.384 349.378 1.00 24.96 ? 76  THR A OG1 1 
ATOM   57   C CG2 . THR A 1 76  ? 219.437 277.906 348.036 1.00 15.76 ? 76  THR A CG2 1 
ATOM   58   N N   . VAL A 1 77  ? 221.173 276.931 352.076 1.00 14.09 ? 77  VAL A N   1 
ATOM   59   C CA  . VAL A 1 77  ? 222.031 277.022 353.253 1.00 15.42 ? 77  VAL A CA  1 
ATOM   60   C C   . VAL A 1 77  ? 222.951 278.230 353.143 1.00 14.99 ? 77  VAL A C   1 
ATOM   61   O O   . VAL A 1 77  ? 223.238 278.904 354.138 1.00 19.03 ? 77  VAL A O   1 
ATOM   62   C CB  . VAL A 1 77  ? 222.821 275.713 353.437 1.00 11.99 ? 77  VAL A CB  1 
ATOM   63   C CG1 . VAL A 1 77  ? 223.918 275.891 354.465 1.00 17.50 ? 77  VAL A CG1 1 
ATOM   64   C CG2 . VAL A 1 77  ? 221.883 274.594 353.853 1.00 12.76 ? 77  VAL A CG2 1 
ATOM   65   N N   . GLU A 1 78  ? 223.427 278.522 351.932 1.00 14.47 ? 78  GLU A N   1 
ATOM   66   C CA  . GLU A 1 78  ? 224.243 279.711 351.717 1.00 13.38 ? 78  GLU A CA  1 
ATOM   67   C C   . GLU A 1 78  ? 223.502 280.972 352.146 1.00 18.22 ? 78  GLU A C   1 
ATOM   68   O O   . GLU A 1 78  ? 224.016 281.769 352.938 1.00 17.17 ? 78  GLU A O   1 
ATOM   69   C CB  . GLU A 1 78  ? 224.641 279.800 350.244 1.00 14.05 ? 78  GLU A CB  1 
ATOM   70   C CG  . GLU A 1 78  ? 225.733 280.811 349.952 1.00 15.81 ? 78  GLU A CG  1 
ATOM   71   C CD  . GLU A 1 78  ? 227.092 280.351 350.434 1.00 22.55 ? 78  GLU A CD  1 
ATOM   72   O OE1 . GLU A 1 78  ? 227.255 279.140 350.682 1.00 26.45 ? 78  GLU A OE1 1 
ATOM   73   O OE2 . GLU A 1 78  ? 227.997 281.199 350.566 1.00 21.86 ? 78  GLU A OE2 1 
ATOM   74   N N   . SER A 1 79  ? 222.279 281.160 351.642 1.00 17.06 ? 79  SER A N   1 
ATOM   75   C CA  . SER A 1 79  ? 221.518 282.369 351.946 1.00 13.22 ? 79  SER A CA  1 
ATOM   76   C C   . SER A 1 79  ? 221.134 282.435 353.417 1.00 12.19 ? 79  SER A C   1 
ATOM   77   O O   . SER A 1 79  ? 221.053 283.524 353.994 1.00 20.72 ? 79  SER A O   1 
ATOM   78   C CB  . SER A 1 79  ? 220.266 282.434 351.073 1.00 19.21 ? 79  SER A CB  1 
ATOM   79   O OG  . SER A 1 79  ? 220.601 282.514 349.703 1.00 25.14 ? 79  SER A OG  1 
ATOM   80   N N   . PHE A 1 80  ? 220.883 281.283 354.038 1.00 17.14 ? 80  PHE A N   1 
ATOM   81   C CA  . PHE A 1 80  ? 220.487 281.266 355.440 1.00 12.14 ? 80  PHE A CA  1 
ATOM   82   C C   . PHE A 1 80  ? 221.576 281.842 356.339 1.00 14.15 ? 80  PHE A C   1 
ATOM   83   O O   . PHE A 1 80  ? 221.268 282.470 357.356 1.00 8.94  ? 80  PHE A O   1 
ATOM   84   C CB  . PHE A 1 80  ? 220.140 279.834 355.855 1.00 12.25 ? 80  PHE A CB  1 
ATOM   85   C CG  . PHE A 1 80  ? 219.571 279.718 357.241 1.00 13.35 ? 80  PHE A CG  1 
ATOM   86   C CD1 . PHE A 1 80  ? 218.300 280.183 357.525 1.00 7.66  ? 80  PHE A CD1 1 
ATOM   87   C CD2 . PHE A 1 80  ? 220.301 279.124 358.254 1.00 10.00 ? 80  PHE A CD2 1 
ATOM   88   C CE1 . PHE A 1 80  ? 217.776 280.073 358.794 1.00 3.38  ? 80  PHE A CE1 1 
ATOM   89   C CE2 . PHE A 1 80  ? 219.782 279.008 359.525 1.00 11.65 ? 80  PHE A CE2 1 
ATOM   90   C CZ  . PHE A 1 80  ? 218.517 279.484 359.797 1.00 4.99  ? 80  PHE A CZ  1 
ATOM   91   N N   . PHE A 1 81  ? 222.844 281.656 355.976 1.00 17.00 ? 81  PHE A N   1 
ATOM   92   C CA  . PHE A 1 81  ? 223.968 282.092 356.795 1.00 14.77 ? 81  PHE A CA  1 
ATOM   93   C C   . PHE A 1 81  ? 224.700 283.300 356.219 1.00 13.75 ? 81  PHE A C   1 
ATOM   94   O O   . PHE A 1 81  ? 225.732 283.698 356.763 1.00 24.78 ? 81  PHE A O   1 
ATOM   95   C CB  . PHE A 1 81  ? 224.952 280.933 356.991 1.00 14.48 ? 81  PHE A CB  1 
ATOM   96   C CG  . PHE A 1 81  ? 224.445 279.853 357.903 1.00 8.87  ? 81  PHE A CG  1 
ATOM   97   C CD1 . PHE A 1 81  ? 224.370 280.063 359.266 1.00 10.75 ? 81  PHE A CD1 1 
ATOM   98   C CD2 . PHE A 1 81  ? 224.052 278.627 357.400 1.00 10.21 ? 81  PHE A CD2 1 
ATOM   99   C CE1 . PHE A 1 81  ? 223.909 279.076 360.108 1.00 13.56 ? 81  PHE A CE1 1 
ATOM   100  C CE2 . PHE A 1 81  ? 223.588 277.636 358.243 1.00 16.65 ? 81  PHE A CE2 1 
ATOM   101  C CZ  . PHE A 1 81  ? 223.522 277.862 359.597 1.00 10.29 ? 81  PHE A CZ  1 
ATOM   102  N N   . ALA A 1 82  ? 224.186 283.907 355.151 1.00 19.79 ? 82  ALA A N   1 
ATOM   103  C CA  . ALA A 1 82  ? 224.896 284.984 354.471 1.00 15.88 ? 82  ALA A CA  1 
ATOM   104  C C   . ALA A 1 82  ? 224.705 286.323 355.175 1.00 21.06 ? 82  ALA A C   1 
ATOM   105  O O   . ALA A 1 82  ? 224.307 287.309 354.550 1.00 20.83 ? 82  ALA A O   1 
ATOM   106  C CB  . ALA A 1 82  ? 224.431 285.081 353.018 1.00 4.31  ? 82  ALA A CB  1 
ATOM   107  N N   . ARG A 1 83  ? 225.003 286.371 356.470 1.00 18.06 ? 83  ARG A N   1 
ATOM   108  C CA  . ARG A 1 83  ? 224.841 287.573 357.271 1.00 10.76 ? 83  ARG A CA  1 
ATOM   109  C C   . ARG A 1 83  ? 225.997 287.681 358.248 1.00 11.34 ? 83  ARG A C   1 
ATOM   110  O O   . ARG A 1 83  ? 226.466 286.670 358.776 1.00 27.36 ? 83  ARG A O   1 
ATOM   111  C CB  . ARG A 1 83  ? 223.522 287.562 358.053 1.00 15.14 ? 83  ARG A CB  1 
ATOM   112  C CG  . ARG A 1 83  ? 222.273 287.657 357.201 1.00 14.72 ? 83  ARG A CG  1 
ATOM   113  C CD  . ARG A 1 83  ? 222.167 288.998 356.499 1.00 10.35 ? 83  ARG A CD  1 
ATOM   114  N NE  . ARG A 1 83  ? 220.846 289.196 355.918 1.00 14.90 ? 83  ARG A NE  1 
ATOM   115  C CZ  . ARG A 1 83  ? 220.450 288.696 354.756 1.00 15.08 ? 83  ARG A CZ  1 
ATOM   116  N NH1 . ARG A 1 83  ? 221.257 287.966 354.006 1.00 14.16 ? 83  ARG A NH1 1 
ATOM   117  N NH2 . ARG A 1 83  ? 219.212 288.931 354.338 1.00 17.87 ? 83  ARG A NH2 1 
ATOM   118  N N   . GLY A 1 84  ? 226.446 288.908 358.490 1.00 15.52 ? 84  GLY A N   1 
ATOM   119  C CA  . GLY A 1 84  ? 227.439 289.150 359.514 1.00 13.92 ? 84  GLY A CA  1 
ATOM   120  C C   . GLY A 1 84  ? 226.807 289.218 360.887 1.00 16.76 ? 84  GLY A C   1 
ATOM   121  O O   . GLY A 1 84  ? 226.026 290.129 361.169 1.00 22.35 ? 84  GLY A O   1 
ATOM   122  N N   . ALA A 1 85  ? 227.133 288.264 361.750 1.00 17.85 ? 85  ALA A N   1 
ATOM   123  C CA  . ALA A 1 85  ? 226.547 288.163 363.077 1.00 16.93 ? 85  ALA A CA  1 
ATOM   124  C C   . ALA A 1 85  ? 227.577 288.542 364.129 1.00 17.49 ? 85  ALA A C   1 
ATOM   125  O O   . ALA A 1 85  ? 228.728 288.104 364.070 1.00 19.11 ? 85  ALA A O   1 
ATOM   126  C CB  . ALA A 1 85  ? 226.032 286.746 363.343 1.00 13.33 ? 85  ALA A CB  1 
ATOM   127  N N   . CYS A 1 86  ? 227.158 289.354 365.092 1.00 12.53 ? 86  CYS A N   1 
ATOM   128  C CA  . CYS A 1 86  ? 228.041 289.740 366.181 1.00 13.89 ? 86  CYS A CA  1 
ATOM   129  C C   . CYS A 1 86  ? 228.307 288.542 367.085 1.00 22.12 ? 86  CYS A C   1 
ATOM   130  O O   . CYS A 1 86  ? 227.374 287.867 367.527 1.00 25.00 ? 86  CYS A O   1 
ATOM   131  C CB  . CYS A 1 86  ? 227.422 290.884 366.983 1.00 13.03 ? 86  CYS A CB  1 
ATOM   132  S SG  . CYS A 1 86  ? 228.526 291.650 368.193 1.00 31.88 ? 86  CYS A SG  1 
ATOM   133  N N   . VAL A 1 87  ? 229.582 288.281 367.362 1.00 17.46 ? 87  VAL A N   1 
ATOM   134  C CA  . VAL A 1 87  ? 229.976 287.177 368.229 1.00 16.16 ? 87  VAL A CA  1 
ATOM   135  C C   . VAL A 1 87  ? 230.795 287.628 369.426 1.00 17.20 ? 87  VAL A C   1 
ATOM   136  O O   . VAL A 1 87  ? 230.983 286.832 370.357 1.00 25.38 ? 87  VAL A O   1 
ATOM   137  C CB  . VAL A 1 87  ? 230.749 286.089 367.449 1.00 16.11 ? 87  VAL A CB  1 
ATOM   138  C CG1 . VAL A 1 87  ? 229.824 285.347 366.506 1.00 18.80 ? 87  VAL A CG1 1 
ATOM   139  C CG2 . VAL A 1 87  ? 231.913 286.695 366.685 1.00 15.14 ? 87  VAL A CG2 1 
ATOM   140  N N   . ALA A 1 88  ? 231.288 288.863 369.450 1.00 15.54 ? 88  ALA A N   1 
ATOM   141  C CA  . ALA A 1 88  ? 232.126 289.300 370.556 1.00 11.96 ? 88  ALA A CA  1 
ATOM   142  C C   . ALA A 1 88  ? 232.181 290.818 370.605 1.00 15.18 ? 88  ALA A C   1 
ATOM   143  O O   . ALA A 1 88  ? 232.119 291.492 369.572 1.00 19.99 ? 88  ALA A O   1 
ATOM   144  C CB  . ALA A 1 88  ? 233.544 288.737 370.433 1.00 17.71 ? 88  ALA A CB  1 
ATOM   145  N N   . ILE A 1 89  ? 232.320 291.335 371.822 1.00 18.05 ? 89  ILE A N   1 
ATOM   146  C CA  . ILE A 1 89  ? 232.625 292.736 372.082 1.00 16.34 ? 89  ILE A CA  1 
ATOM   147  C C   . ILE A 1 89  ? 233.875 292.746 372.952 1.00 19.49 ? 89  ILE A C   1 
ATOM   148  O O   . ILE A 1 89  ? 233.801 292.511 374.163 1.00 28.06 ? 89  ILE A O   1 
ATOM   149  C CB  . ILE A 1 89  ? 231.467 293.473 372.765 1.00 21.45 ? 89  ILE A CB  1 
ATOM   150  C CG1 . ILE A 1 89  ? 230.184 293.319 371.946 1.00 17.80 ? 89  ILE A CG1 1 
ATOM   151  C CG2 . ILE A 1 89  ? 231.810 294.948 372.949 1.00 23.77 ? 89  ILE A CG2 1 
ATOM   152  C CD1 . ILE A 1 89  ? 229.012 294.088 372.491 1.00 15.65 ? 89  ILE A CD1 1 
ATOM   153  N N   . ILE A 1 90  ? 235.023 293.022 372.344 1.00 19.78 ? 90  ILE A N   1 
ATOM   154  C CA  . ILE A 1 90  ? 236.299 293.052 373.048 1.00 18.91 ? 90  ILE A CA  1 
ATOM   155  C C   . ILE A 1 90  ? 236.571 294.481 373.492 1.00 22.26 ? 90  ILE A C   1 
ATOM   156  O O   . ILE A 1 90  ? 236.551 295.406 372.677 1.00 26.46 ? 90  ILE A O   1 
ATOM   157  C CB  . ILE A 1 90  ? 237.431 292.532 372.148 1.00 16.90 ? 90  ILE A CB  1 
ATOM   158  C CG1 . ILE A 1 90  ? 237.091 291.140 371.609 1.00 18.02 ? 90  ILE A CG1 1 
ATOM   159  C CG2 . ILE A 1 90  ? 238.742 292.511 372.913 1.00 19.12 ? 90  ILE A CG2 1 
ATOM   160  C CD1 . ILE A 1 90  ? 237.946 290.714 370.450 1.00 16.76 ? 90  ILE A CD1 1 
ATOM   161  N N   . GLU A 1 91  ? 236.835 294.666 374.779 1.00 22.97 ? 91  GLU A N   1 
ATOM   162  C CA  . GLU A 1 91  ? 237.022 295.989 375.354 1.00 26.56 ? 91  GLU A CA  1 
ATOM   163  C C   . GLU A 1 91  ? 238.496 296.218 375.659 1.00 26.98 ? 91  GLU A C   1 
ATOM   164  O O   . GLU A 1 91  ? 239.141 295.374 376.286 1.00 27.74 ? 91  GLU A O   1 
ATOM   165  C CB  . GLU A 1 91  ? 236.188 296.146 376.625 1.00 25.10 ? 91  GLU A CB  1 
ATOM   166  C CG  . GLU A 1 91  ? 236.009 297.581 377.061 1.00 33.67 ? 91  GLU A CG  1 
ATOM   167  C CD  . GLU A 1 91  ? 235.127 297.711 378.282 1.00 38.29 ? 91  GLU A CD  1 
ATOM   168  O OE1 . GLU A 1 91  ? 234.391 296.751 378.586 1.00 32.91 ? 91  GLU A OE1 1 
ATOM   169  O OE2 . GLU A 1 91  ? 235.171 298.773 378.938 1.00 37.90 ? 91  GLU A OE2 1 
ATOM   170  N N   . VAL A 1 92  ? 239.024 297.358 375.215 1.00 28.20 ? 92  VAL A N   1 
ATOM   171  C CA  . VAL A 1 92  ? 240.399 297.744 375.507 1.00 32.12 ? 92  VAL A CA  1 
ATOM   172  C C   . VAL A 1 92  ? 240.419 299.194 375.962 1.00 26.03 ? 92  VAL A C   1 
ATOM   173  O O   . VAL A 1 92  ? 239.476 299.955 375.730 1.00 33.90 ? 92  VAL A O   1 
ATOM   174  C CB  . VAL A 1 92  ? 241.343 297.552 374.296 1.00 29.08 ? 92  VAL A CB  1 
ATOM   175  C CG1 . VAL A 1 92  ? 241.428 296.086 373.913 1.00 27.45 ? 92  VAL A CG1 1 
ATOM   176  C CG2 . VAL A 1 92  ? 240.892 298.395 373.118 1.00 23.42 ? 92  VAL A CG2 1 
ATOM   177  N N   . ASP A 1 93  ? 241.505 299.571 376.622 1.00 32.08 ? 93  ASP A N   1 
ATOM   178  C CA  . ASP A 1 93  ? 241.692 300.920 377.123 1.00 30.12 ? 93  ASP A CA  1 
ATOM   179  C C   . ASP A 1 93  ? 243.023 301.478 376.638 1.00 36.37 ? 93  ASP A C   1 
ATOM   180  O O   . ASP A 1 93  ? 243.999 300.748 376.443 1.00 36.19 ? 93  ASP A O   1 
ATOM   181  C CB  . ASP A 1 93  ? 241.648 300.957 378.652 1.00 34.20 ? 93  ASP A CB  1 
ATOM   182  C CG  . ASP A 1 93  ? 240.326 300.469 379.213 1.00 43.67 ? 93  ASP A CG  1 
ATOM   183  O OD1 . ASP A 1 93  ? 239.300 300.568 378.509 1.00 43.46 ? 93  ASP A OD1 1 
ATOM   184  O OD2 . ASP A 1 93  ? 240.311 299.989 380.365 1.00 43.52 ? 93  ASP A OD2 1 
ATOM   185  N N   . ASN A 1 94  ? 243.043 302.792 376.443 1.00 41.79 ? 94  ASN A N   1 
ATOM   186  C CA  . ASN A 1 94  ? 244.244 303.556 376.126 1.00 34.34 ? 94  ASN A CA  1 
ATOM   187  C C   . ASN A 1 94  ? 244.444 304.502 377.304 1.00 40.60 ? 94  ASN A C   1 
ATOM   188  O O   . ASN A 1 94  ? 243.778 305.539 377.409 1.00 43.50 ? 94  ASN A O   1 
ATOM   189  C CB  . ASN A 1 94  ? 244.101 304.299 374.805 1.00 34.21 ? 94  ASN A CB  1 
ATOM   190  C CG  . ASN A 1 94  ? 245.341 305.077 374.438 1.00 39.30 ? 94  ASN A CG  1 
ATOM   191  O OD1 . ASN A 1 94  ? 246.388 304.927 375.064 1.00 45.62 ? 94  ASN A OD1 1 
ATOM   192  N ND2 . ASN A 1 94  ? 245.234 305.912 373.413 1.00 42.05 ? 94  ASN A ND2 1 
ATOM   193  N N   . ASP A 1 95  ? 245.348 304.115 378.201 1.00 46.95 ? 95  ASP A N   1 
ATOM   194  C CA  . ASP A 1 95  ? 245.582 304.802 379.459 1.00 49.07 ? 95  ASP A CA  1 
ATOM   195  C C   . ASP A 1 95  ? 247.009 304.538 379.916 1.00 45.88 ? 95  ASP A C   1 
ATOM   196  O O   . ASP A 1 95  ? 247.656 303.582 379.482 1.00 43.67 ? 95  ASP A O   1 
ATOM   197  C CB  . ASP A 1 95  ? 244.589 304.332 380.527 1.00 47.98 ? 95  ASP A CB  1 
ATOM   198  C CG  . ASP A 1 95  ? 244.501 305.279 381.704 1.00 51.73 ? 95  ASP A CG  1 
ATOM   199  O OD1 . ASP A 1 95  ? 245.444 306.076 381.908 1.00 50.00 ? 95  ASP A OD1 1 
ATOM   200  O OD2 . ASP A 1 95  ? 243.488 305.223 382.430 1.00 50.05 ? 95  ASP A OD2 1 
ATOM   201  N N   . ALA A 1 96  ? 247.499 305.390 380.808 1.00 48.84 ? 96  ALA A N   1 
ATOM   202  C CA  . ALA A 1 96  ? 248.840 305.205 381.354 1.00 52.18 ? 96  ALA A CA  1 
ATOM   203  C C   . ALA A 1 96  ? 248.849 304.020 382.317 1.00 52.61 ? 96  ALA A C   1 
ATOM   204  O O   . ALA A 1 96  ? 247.904 303.857 383.095 1.00 52.61 ? 96  ALA A O   1 
ATOM   205  C CB  . ALA A 1 96  ? 249.310 306.465 382.072 1.00 51.95 ? 96  ALA A CB  1 
ATOM   206  N N   . PRO A 1 97  ? 249.895 303.179 382.305 1.00 52.43 ? 97  PRO A N   1 
ATOM   207  C CA  . PRO A 1 97  ? 249.913 301.983 383.153 1.00 52.97 ? 97  PRO A CA  1 
ATOM   208  C C   . PRO A 1 97  ? 250.155 302.295 384.627 1.00 51.64 ? 97  PRO A C   1 
ATOM   209  O O   . PRO A 1 97  ? 251.307 302.481 385.018 1.00 53.33 ? 97  PRO A O   1 
ATOM   210  C CB  . PRO A 1 97  ? 251.070 301.167 382.572 1.00 49.99 ? 97  PRO A CB  1 
ATOM   211  C CG  . PRO A 1 97  ? 251.994 302.182 382.014 1.00 51.35 ? 97  PRO A CG  1 
ATOM   212  C CD  . PRO A 1 97  ? 251.136 303.315 381.522 1.00 51.99 ? 97  PRO A CD  1 
ATOM   213  N N   . ALA A 1 101 ? 243.869 299.126 387.246 1.00 54.36 ? 101 ALA A N   1 
ATOM   214  C CA  . ALA A 1 101 ? 242.419 299.154 387.097 1.00 54.92 ? 101 ALA A CA  1 
ATOM   215  C C   . ALA A 1 101 ? 242.016 299.164 385.626 1.00 53.69 ? 101 ALA A C   1 
ATOM   216  O O   . ALA A 1 101 ? 240.853 298.944 385.290 1.00 54.57 ? 101 ALA A O   1 
ATOM   217  C CB  . ALA A 1 101 ? 241.840 300.363 387.809 1.00 55.79 ? 101 ALA A CB  1 
ATOM   218  N N   . SER A 1 102 ? 242.982 299.424 384.753 1.00 48.86 ? 102 SER A N   1 
ATOM   219  C CA  . SER A 1 102 ? 242.756 299.464 383.318 1.00 47.96 ? 102 SER A CA  1 
ATOM   220  C C   . SER A 1 102 ? 243.224 298.161 382.676 1.00 49.75 ? 102 SER A C   1 
ATOM   221  O O   . SER A 1 102 ? 243.890 297.332 383.299 1.00 51.26 ? 102 SER A O   1 
ATOM   222  C CB  . SER A 1 102 ? 243.483 300.662 382.700 1.00 47.85 ? 102 SER A CB  1 
ATOM   223  O OG  . SER A 1 102 ? 243.171 300.794 381.327 1.00 51.98 ? 102 SER A OG  1 
ATOM   224  N N   . LYS A 1 103 ? 242.859 297.987 381.408 1.00 39.74 ? 103 LYS A N   1 
ATOM   225  C CA  . LYS A 1 103 ? 243.232 296.806 380.629 1.00 39.65 ? 103 LYS A CA  1 
ATOM   226  C C   . LYS A 1 103 ? 243.811 297.285 379.302 1.00 35.76 ? 103 LYS A C   1 
ATOM   227  O O   . LYS A 1 103 ? 243.068 297.578 378.361 1.00 35.71 ? 103 LYS A O   1 
ATOM   228  C CB  . LYS A 1 103 ? 242.037 295.884 380.418 1.00 36.90 ? 103 LYS A CB  1 
ATOM   229  C CG  . LYS A 1 103 ? 240.734 296.617 380.177 1.00 38.77 ? 103 LYS A CG  1 
ATOM   230  C CD  . LYS A 1 103 ? 239.612 295.664 379.822 1.00 37.40 ? 103 LYS A CD  1 
ATOM   231  C CE  . LYS A 1 103 ? 238.257 296.325 380.003 1.00 39.71 ? 103 LYS A CE  1 
ATOM   232  N NZ  . LYS A 1 103 ? 238.221 297.687 379.402 1.00 41.95 ? 103 LYS A NZ  1 
ATOM   233  N N   . LEU A 1 104 ? 245.138 297.353 379.231 1.00 32.78 ? 104 LEU A N   1 
ATOM   234  C CA  . LEU A 1 104 ? 245.819 297.864 378.052 1.00 30.31 ? 104 LEU A CA  1 
ATOM   235  C C   . LEU A 1 104 ? 245.808 296.886 376.886 1.00 32.32 ? 104 LEU A C   1 
ATOM   236  O O   . LEU A 1 104 ? 246.195 297.270 375.778 1.00 36.03 ? 104 LEU A O   1 
ATOM   237  C CB  . LEU A 1 104 ? 247.261 298.228 378.407 1.00 34.95 ? 104 LEU A CB  1 
ATOM   238  C CG  . LEU A 1 104 ? 247.422 299.081 379.668 1.00 35.98 ? 104 LEU A CG  1 
ATOM   239  C CD1 . LEU A 1 104 ? 248.880 299.406 379.904 1.00 36.11 ? 104 LEU A CD1 1 
ATOM   240  C CD2 . LEU A 1 104 ? 246.598 300.351 379.580 1.00 36.80 ? 104 LEU A CD2 1 
ATOM   241  N N   . PHE A 1 105 ? 245.381 295.645 377.101 1.00 25.03 ? 105 PHE A N   1 
ATOM   242  C CA  . PHE A 1 105 ? 245.225 294.694 376.012 1.00 22.26 ? 105 PHE A CA  1 
ATOM   243  C C   . PHE A 1 105 ? 244.256 293.612 376.458 1.00 24.43 ? 105 PHE A C   1 
ATOM   244  O O   . PHE A 1 105 ? 244.116 293.344 377.653 1.00 26.88 ? 105 PHE A O   1 
ATOM   245  C CB  . PHE A 1 105 ? 246.568 294.082 375.591 1.00 21.75 ? 105 PHE A CB  1 
ATOM   246  C CG  . PHE A 1 105 ? 247.148 293.138 376.601 1.00 26.64 ? 105 PHE A CG  1 
ATOM   247  C CD1 . PHE A 1 105 ? 247.817 293.616 377.710 1.00 24.27 ? 105 PHE A CD1 1 
ATOM   248  C CD2 . PHE A 1 105 ? 247.025 291.769 376.440 1.00 22.34 ? 105 PHE A CD2 1 
ATOM   249  C CE1 . PHE A 1 105 ? 248.352 292.750 378.640 1.00 23.58 ? 105 PHE A CE1 1 
ATOM   250  C CE2 . PHE A 1 105 ? 247.559 290.900 377.366 1.00 23.35 ? 105 PHE A CE2 1 
ATOM   251  C CZ  . PHE A 1 105 ? 248.223 291.392 378.468 1.00 24.12 ? 105 PHE A CZ  1 
ATOM   252  N N   . SER A 1 106 ? 243.587 292.998 375.487 1.00 25.76 ? 106 SER A N   1 
ATOM   253  C CA  . SER A 1 106 ? 242.570 291.993 375.764 1.00 21.94 ? 106 SER A CA  1 
ATOM   254  C C   . SER A 1 106 ? 242.776 290.767 374.891 1.00 22.94 ? 106 SER A C   1 
ATOM   255  O O   . SER A 1 106 ? 243.155 290.878 373.724 1.00 24.74 ? 106 SER A O   1 
ATOM   256  C CB  . SER A 1 106 ? 241.163 292.550 375.541 1.00 24.83 ? 106 SER A CB  1 
ATOM   257  O OG  . SER A 1 106 ? 240.849 293.533 376.506 1.00 33.51 ? 106 SER A OG  1 
ATOM   258  N N   . ILE A 1 107 ? 242.513 289.597 375.465 1.00 19.27 ? 107 ILE A N   1 
ATOM   259  C CA  . ILE A 1 107 ? 242.576 288.324 374.757 1.00 16.72 ? 107 ILE A CA  1 
ATOM   260  C C   . ILE A 1 107 ? 241.164 287.766 374.667 1.00 17.45 ? 107 ILE A C   1 
ATOM   261  O O   . ILE A 1 107 ? 240.480 287.627 375.687 1.00 22.65 ? 107 ILE A O   1 
ATOM   262  C CB  . ILE A 1 107 ? 243.508 287.324 375.464 1.00 21.84 ? 107 ILE A CB  1 
ATOM   263  C CG1 . ILE A 1 107 ? 244.876 287.954 375.745 1.00 20.39 ? 107 ILE A CG1 1 
ATOM   264  C CG2 . ILE A 1 107 ? 243.658 286.059 374.630 1.00 20.89 ? 107 ILE A CG2 1 
ATOM   265  C CD1 . ILE A 1 107 ? 245.643 288.357 374.510 1.00 24.89 ? 107 ILE A CD1 1 
ATOM   266  N N   . TRP A 1 108 ? 240.727 287.452 373.451 1.00 16.17 ? 108 TRP A N   1 
ATOM   267  C CA  . TRP A 1 108 ? 239.426 286.838 373.218 1.00 11.85 ? 108 TRP A CA  1 
ATOM   268  C C   . TRP A 1 108 ? 239.627 285.507 372.512 1.00 18.36 ? 108 TRP A C   1 
ATOM   269  O O   . TRP A 1 108 ? 240.173 285.465 371.407 1.00 19.31 ? 108 TRP A O   1 
ATOM   270  C CB  . TRP A 1 108 ? 238.522 287.750 372.386 1.00 15.92 ? 108 TRP A CB  1 
ATOM   271  C CG  . TRP A 1 108 ? 237.251 287.087 371.949 1.00 14.08 ? 108 TRP A CG  1 
ATOM   272  C CD1 . TRP A 1 108 ? 236.187 286.761 372.732 1.00 15.48 ? 108 TRP A CD1 1 
ATOM   273  C CD2 . TRP A 1 108 ? 236.914 286.668 370.622 1.00 16.04 ? 108 TRP A CD2 1 
ATOM   274  N NE1 . TRP A 1 108 ? 235.211 286.164 371.981 1.00 18.20 ? 108 TRP A NE1 1 
ATOM   275  C CE2 . TRP A 1 108 ? 235.632 286.094 370.681 1.00 16.48 ? 108 TRP A CE2 1 
ATOM   276  C CE3 . TRP A 1 108 ? 237.573 286.720 369.392 1.00 12.44 ? 108 TRP A CE3 1 
ATOM   277  C CZ2 . TRP A 1 108 ? 234.993 285.582 369.557 1.00 9.51  ? 108 TRP A CZ2 1 
ATOM   278  C CZ3 . TRP A 1 108 ? 236.938 286.210 368.279 1.00 12.16 ? 108 TRP A CZ3 1 
ATOM   279  C CH2 . TRP A 1 108 ? 235.661 285.650 368.368 1.00 15.02 ? 108 TRP A CH2 1 
ATOM   280  N N   . LYS A 1 109 ? 239.174 284.428 373.141 1.00 18.40 ? 109 LYS A N   1 
ATOM   281  C CA  . LYS A 1 109 ? 239.218 283.115 372.516 1.00 17.10 ? 109 LYS A CA  1 
ATOM   282  C C   . LYS A 1 109 ? 238.127 283.021 371.455 1.00 18.14 ? 109 LYS A C   1 
ATOM   283  O O   . LYS A 1 109 ? 236.967 283.351 371.711 1.00 24.04 ? 109 LYS A O   1 
ATOM   284  C CB  . LYS A 1 109 ? 239.056 282.023 373.572 1.00 13.71 ? 109 LYS A CB  1 
ATOM   285  C CG  . LYS A 1 109 ? 239.008 280.615 373.016 1.00 16.17 ? 109 LYS A CG  1 
ATOM   286  C CD  . LYS A 1 109 ? 239.503 279.605 374.032 1.00 18.71 ? 109 LYS A CD  1 
ATOM   287  C CE  . LYS A 1 109 ? 239.058 278.191 373.691 1.00 21.55 ? 109 LYS A CE  1 
ATOM   288  N NZ  . LYS A 1 109 ? 239.403 277.785 372.302 1.00 23.82 ? 109 LYS A NZ  1 
ATOM   289  N N   . ILE A 1 110 ? 238.502 282.563 370.266 1.00 19.06 ? 110 ILE A N   1 
ATOM   290  C CA  . ILE A 1 110 ? 237.641 282.663 369.093 1.00 17.90 ? 110 ILE A CA  1 
ATOM   291  C C   . ILE A 1 110 ? 236.559 281.593 369.162 1.00 18.51 ? 110 ILE A C   1 
ATOM   292  O O   . ILE A 1 110 ? 236.850 280.394 369.137 1.00 25.05 ? 110 ILE A O   1 
ATOM   293  C CB  . ILE A 1 110 ? 238.460 282.540 367.801 1.00 17.59 ? 110 ILE A CB  1 
ATOM   294  C CG1 . ILE A 1 110 ? 239.476 283.681 367.711 1.00 17.43 ? 110 ILE A CG1 1 
ATOM   295  C CG2 . ILE A 1 110 ? 237.543 282.540 366.592 1.00 21.26 ? 110 ILE A CG2 1 
ATOM   296  C CD1 . ILE A 1 110 ? 240.550 283.461 366.684 1.00 20.30 ? 110 ILE A CD1 1 
ATOM   297  N N   . THR A 1 111 ? 235.304 282.030 369.233 1.00 22.94 ? 111 THR A N   1 
ATOM   298  C CA  . THR A 1 111 ? 234.174 281.116 369.303 1.00 16.17 ? 111 THR A CA  1 
ATOM   299  C C   . THR A 1 111 ? 232.912 281.863 368.899 1.00 18.11 ? 111 THR A C   1 
ATOM   300  O O   . THR A 1 111 ? 232.850 283.093 368.964 1.00 21.31 ? 111 THR A O   1 
ATOM   301  C CB  . THR A 1 111 ? 234.017 280.526 370.709 1.00 15.32 ? 111 THR A CB  1 
ATOM   302  O OG1 . THR A 1 111 ? 232.979 279.540 370.703 1.00 25.52 ? 111 THR A OG1 1 
ATOM   303  C CG2 . THR A 1 111 ? 233.673 281.611 371.714 1.00 17.59 ? 111 THR A CG2 1 
ATOM   304  N N   . TYR A 1 112 ? 231.902 281.100 368.488 1.00 25.34 ? 112 TYR A N   1 
ATOM   305  C CA  . TYR A 1 112 ? 230.587 281.648 368.191 1.00 17.14 ? 112 TYR A CA  1 
ATOM   306  C C   . TYR A 1 112 ? 229.583 281.395 369.309 1.00 13.16 ? 112 TYR A C   1 
ATOM   307  O O   . TYR A 1 112 ? 228.398 281.688 369.137 1.00 27.40 ? 112 TYR A O   1 
ATOM   308  C CB  . TYR A 1 112 ? 230.056 281.074 366.875 1.00 16.30 ? 112 TYR A CB  1 
ATOM   309  C CG  . TYR A 1 112 ? 229.870 279.573 366.872 1.00 20.81 ? 112 TYR A CG  1 
ATOM   310  C CD1 . TYR A 1 112 ? 228.793 278.983 367.523 1.00 19.62 ? 112 TYR A CD1 1 
ATOM   311  C CD2 . TYR A 1 112 ? 230.762 278.747 366.208 1.00 20.71 ? 112 TYR A CD2 1 
ATOM   312  C CE1 . TYR A 1 112 ? 228.622 277.619 367.523 1.00 18.81 ? 112 TYR A CE1 1 
ATOM   313  C CE2 . TYR A 1 112 ? 230.594 277.380 366.201 1.00 20.31 ? 112 TYR A CE2 1 
ATOM   314  C CZ  . TYR A 1 112 ? 229.524 276.821 366.858 1.00 18.10 ? 112 TYR A CZ  1 
ATOM   315  O OH  . TYR A 1 112 ? 229.357 275.457 366.850 1.00 19.65 ? 112 TYR A OH  1 
ATOM   316  N N   . LYS A 1 113 ? 230.026 280.863 370.446 1.00 17.11 ? 113 LYS A N   1 
ATOM   317  C CA  . LYS A 1 113 ? 229.132 280.469 371.526 1.00 19.48 ? 113 LYS A CA  1 
ATOM   318  C C   . LYS A 1 113 ? 229.012 281.521 372.619 1.00 17.39 ? 113 LYS A C   1 
ATOM   319  O O   . LYS A 1 113 ? 228.368 281.264 373.638 1.00 27.64 ? 113 LYS A O   1 
ATOM   320  C CB  . LYS A 1 113 ? 229.592 279.141 372.129 1.00 21.65 ? 113 LYS A CB  1 
ATOM   321  C CG  . LYS A 1 113 ? 229.401 277.967 371.194 1.00 17.58 ? 113 LYS A CG  1 
ATOM   322  C CD  . LYS A 1 113 ? 229.834 276.665 371.819 1.00 19.85 ? 113 LYS A CD  1 
ATOM   323  C CE  . LYS A 1 113 ? 229.574 275.505 370.878 1.00 23.04 ? 113 LYS A CE  1 
ATOM   324  N NZ  . LYS A 1 113 ? 229.990 274.203 371.458 1.00 29.16 ? 113 LYS A NZ  1 
ATOM   325  N N   . ASP A 1 114 ? 229.616 282.694 372.440 1.00 24.56 ? 114 ASP A N   1 
ATOM   326  C CA  . ASP A 1 114 ? 229.374 283.790 373.369 1.00 22.13 ? 114 ASP A CA  1 
ATOM   327  C C   . ASP A 1 114 ? 228.024 284.450 373.124 1.00 28.71 ? 114 ASP A C   1 
ATOM   328  O O   . ASP A 1 114 ? 227.450 285.034 374.048 1.00 35.00 ? 114 ASP A O   1 
ATOM   329  C CB  . ASP A 1 114 ? 230.490 284.829 373.265 1.00 27.50 ? 114 ASP A CB  1 
ATOM   330  C CG  . ASP A 1 114 ? 231.770 284.383 373.945 1.00 33.63 ? 114 ASP A CG  1 
ATOM   331  O OD1 . ASP A 1 114 ? 231.770 283.313 374.589 1.00 31.49 ? 114 ASP A OD1 1 
ATOM   332  O OD2 . ASP A 1 114 ? 232.778 285.110 373.836 1.00 34.47 ? 114 ASP A OD2 1 
ATOM   333  N N   . THR A 1 115 ? 227.511 284.373 371.903 1.00 23.43 ? 115 THR A N   1 
ATOM   334  C CA  . THR A 1 115 ? 226.196 284.882 371.544 1.00 20.24 ? 115 THR A CA  1 
ATOM   335  C C   . THR A 1 115 ? 225.271 283.707 371.242 1.00 21.20 ? 115 THR A C   1 
ATOM   336  O O   . THR A 1 115 ? 225.684 282.545 371.259 1.00 26.67 ? 115 THR A O   1 
ATOM   337  C CB  . THR A 1 115 ? 226.295 285.841 370.356 1.00 24.14 ? 115 THR A CB  1 
ATOM   338  O OG1 . THR A 1 115 ? 227.030 285.222 369.296 1.00 33.73 ? 115 THR A OG1 1 
ATOM   339  C CG2 . THR A 1 115 ? 226.986 287.126 370.768 1.00 16.39 ? 115 THR A CG2 1 
ATOM   340  N N   . VAL A 1 116 ? 224.008 284.014 370.955 1.00 15.01 ? 116 VAL A N   1 
ATOM   341  C CA  . VAL A 1 116 ? 222.964 283.007 370.858 1.00 15.02 ? 116 VAL A CA  1 
ATOM   342  C C   . VAL A 1 116 ? 222.428 282.869 369.438 1.00 15.41 ? 116 VAL A C   1 
ATOM   343  O O   . VAL A 1 116 ? 222.183 281.752 368.977 1.00 22.20 ? 116 VAL A O   1 
ATOM   344  C CB  . VAL A 1 116 ? 221.819 283.307 371.851 1.00 13.30 ? 116 VAL A CB  1 
ATOM   345  C CG1 . VAL A 1 116 ? 222.348 283.322 373.273 1.00 19.85 ? 116 VAL A CG1 1 
ATOM   346  C CG2 . VAL A 1 116 ? 221.135 284.623 371.519 1.00 15.60 ? 116 VAL A CG2 1 
ATOM   347  N N   . GLN A 1 117 ? 222.233 283.980 368.727 1.00 14.27 ? 117 GLN A N   1 
ATOM   348  C CA  . GLN A 1 117 ? 221.512 283.919 367.458 1.00 12.27 ? 117 GLN A CA  1 
ATOM   349  C C   . GLN A 1 117 ? 222.259 283.076 366.431 1.00 8.05  ? 117 GLN A C   1 
ATOM   350  O O   . GLN A 1 117 ? 221.700 282.133 365.852 1.00 19.78 ? 117 GLN A O   1 
ATOM   351  C CB  . GLN A 1 117 ? 221.275 285.332 366.928 1.00 13.59 ? 117 GLN A CB  1 
ATOM   352  C CG  . GLN A 1 117 ? 220.424 286.207 367.830 1.00 10.78 ? 117 GLN A CG  1 
ATOM   353  C CD  . GLN A 1 117 ? 220.131 287.561 367.211 1.00 14.66 ? 117 GLN A CD  1 
ATOM   354  O OE1 . GLN A 1 117 ? 220.785 287.974 366.258 1.00 26.98 ? 117 GLN A OE1 1 
ATOM   355  N NE2 . GLN A 1 117 ? 219.141 288.257 367.751 1.00 19.41 ? 117 GLN A NE2 1 
ATOM   356  N N   . LEU A 1 118 ? 223.532 283.389 366.200 1.00 11.56 ? 118 LEU A N   1 
ATOM   357  C CA  . LEU A 1 118 ? 224.311 282.604 365.252 1.00 12.18 ? 118 LEU A CA  1 
ATOM   358  C C   . LEU A 1 118 ? 224.493 281.176 365.749 1.00 13.93 ? 118 LEU A C   1 
ATOM   359  O O   . LEU A 1 118 ? 224.478 280.232 364.954 1.00 16.42 ? 118 LEU A O   1 
ATOM   360  C CB  . LEU A 1 118 ? 225.665 283.268 365.001 1.00 11.64 ? 118 LEU A CB  1 
ATOM   361  C CG  . LEU A 1 118 ? 226.589 282.525 364.032 1.00 15.98 ? 118 LEU A CG  1 
ATOM   362  C CD1 . LEU A 1 118 ? 225.995 282.491 362.639 1.00 10.89 ? 118 LEU A CD1 1 
ATOM   363  C CD2 . LEU A 1 118 ? 227.966 283.140 364.008 1.00 9.22  ? 118 LEU A CD2 1 
ATOM   364  N N   . ARG A 1 119 ? 224.673 281.001 367.059 1.00 12.46 ? 119 ARG A N   1 
ATOM   365  C CA  . ARG A 1 119 ? 224.819 279.660 367.610 1.00 11.33 ? 119 ARG A CA  1 
ATOM   366  C C   . ARG A 1 119 ? 223.573 278.824 367.348 1.00 14.23 ? 119 ARG A C   1 
ATOM   367  O O   . ARG A 1 119 ? 223.666 277.667 366.926 1.00 14.88 ? 119 ARG A O   1 
ATOM   368  C CB  . ARG A 1 119 ? 225.110 279.738 369.108 1.00 13.91 ? 119 ARG A CB  1 
ATOM   369  C CG  . ARG A 1 119 ? 225.201 278.385 369.783 1.00 9.50  ? 119 ARG A CG  1 
ATOM   370  C CD  . ARG A 1 119 ? 225.435 278.513 371.265 1.00 10.24 ? 119 ARG A CD  1 
ATOM   371  N NE  . ARG A 1 119 ? 225.613 277.210 371.889 1.00 14.60 ? 119 ARG A NE  1 
ATOM   372  C CZ  . ARG A 1 119 ? 225.893 277.021 373.168 1.00 15.09 ? 119 ARG A CZ  1 
ATOM   373  N NH1 . ARG A 1 119 ? 226.032 278.035 374.003 1.00 16.37 ? 119 ARG A NH1 1 
ATOM   374  N NH2 . ARG A 1 119 ? 226.032 275.781 373.623 1.00 8.61  ? 119 ARG A NH2 1 
ATOM   375  N N   . ARG A 1 120 ? 222.392 279.393 367.602 1.00 14.49 ? 120 ARG A N   1 
ATOM   376  C CA  . ARG A 1 120 ? 221.163 278.653 367.352 1.00 13.82 ? 120 ARG A CA  1 
ATOM   377  C C   . ARG A 1 120 ? 221.010 278.336 365.873 1.00 11.59 ? 120 ARG A C   1 
ATOM   378  O O   . ARG A 1 120 ? 220.601 277.229 365.511 1.00 12.70 ? 120 ARG A O   1 
ATOM   379  C CB  . ARG A 1 120 ? 219.954 279.431 367.868 1.00 10.91 ? 120 ARG A CB  1 
ATOM   380  C CG  . ARG A 1 120 ? 218.659 278.632 367.838 1.00 6.13  ? 120 ARG A CG  1 
ATOM   381  C CD  . ARG A 1 120 ? 217.538 279.363 368.539 1.00 14.20 ? 120 ARG A CD  1 
ATOM   382  N NE  . ARG A 1 120 ? 216.336 278.549 368.679 1.00 20.44 ? 120 ARG A NE  1 
ATOM   383  C CZ  . ARG A 1 120 ? 215.337 278.510 367.807 1.00 16.46 ? 120 ARG A CZ  1 
ATOM   384  N NH1 . ARG A 1 120 ? 215.362 279.217 366.690 1.00 8.16  ? 120 ARG A NH1 1 
ATOM   385  N NH2 . ARG A 1 120 ? 214.284 277.742 368.064 1.00 17.91 ? 120 ARG A NH2 1 
ATOM   386  N N   . LYS A 1 121 ? 221.343 279.287 364.999 1.00 11.15 ? 121 LYS A N   1 
ATOM   387  C CA  . LYS A 1 121 ? 221.253 279.010 363.568 1.00 12.47 ? 121 LYS A CA  1 
ATOM   388  C C   . LYS A 1 121 ? 222.190 277.877 363.158 1.00 12.77 ? 121 LYS A C   1 
ATOM   389  O O   . LYS A 1 121 ? 221.817 277.011 362.359 1.00 16.54 ? 121 LYS A O   1 
ATOM   390  C CB  . LYS A 1 121 ? 221.558 280.275 362.766 1.00 12.53 ? 121 LYS A CB  1 
ATOM   391  C CG  . LYS A 1 121 ? 220.460 281.325 362.831 1.00 9.56  ? 121 LYS A CG  1 
ATOM   392  C CD  . LYS A 1 121 ? 220.799 282.558 362.011 1.00 12.11 ? 121 LYS A CD  1 
ATOM   393  C CE  . LYS A 1 121 ? 220.810 282.264 360.521 1.00 11.92 ? 121 LYS A CE  1 
ATOM   394  N NZ  . LYS A 1 121 ? 221.074 283.481 359.716 1.00 19.58 ? 121 LYS A NZ  1 
ATOM   395  N N   . LEU A 1 122 ? 223.416 277.870 363.688 1.00 17.73 ? 122 LEU A N   1 
ATOM   396  C CA  . LEU A 1 122 ? 224.384 276.841 363.316 1.00 11.37 ? 122 LEU A CA  1 
ATOM   397  C C   . LEU A 1 122 ? 223.994 275.476 363.867 1.00 11.37 ? 122 LEU A C   1 
ATOM   398  O O   . LEU A 1 122 ? 224.195 274.454 363.203 1.00 12.24 ? 122 LEU A O   1 
ATOM   399  C CB  . LEU A 1 122 ? 225.777 277.226 363.811 1.00 14.13 ? 122 LEU A CB  1 
ATOM   400  C CG  . LEU A 1 122 ? 226.548 278.248 362.978 1.00 16.73 ? 122 LEU A CG  1 
ATOM   401  C CD1 . LEU A 1 122 ? 227.726 278.775 363.765 1.00 11.34 ? 122 LEU A CD1 1 
ATOM   402  C CD2 . LEU A 1 122 ? 227.006 277.637 361.664 1.00 13.68 ? 122 LEU A CD2 1 
ATOM   403  N N   . GLU A 1 123 ? 223.446 275.438 365.080 1.00 14.26 ? 123 GLU A N   1 
ATOM   404  C CA  . GLU A 1 123 ? 223.113 274.175 365.723 1.00 9.33  ? 123 GLU A CA  1 
ATOM   405  C C   . GLU A 1 123 ? 221.840 273.541 365.178 1.00 12.34 ? 123 GLU A C   1 
ATOM   406  O O   . GLU A 1 123 ? 221.363 272.562 365.757 1.00 13.96 ? 123 GLU A O   1 
ATOM   407  C CB  . GLU A 1 123 ? 223.006 274.382 367.231 1.00 9.01  ? 123 GLU A CB  1 
ATOM   408  C CG  . GLU A 1 123 ? 224.360 274.602 367.881 1.00 7.95  ? 123 GLU A CG  1 
ATOM   409  C CD  . GLU A 1 123 ? 224.266 274.930 369.347 1.00 20.02 ? 123 GLU A CD  1 
ATOM   410  O OE1 . GLU A 1 123 ? 223.139 275.051 369.858 1.00 26.92 ? 123 GLU A OE1 1 
ATOM   411  O OE2 . GLU A 1 123 ? 225.323 275.061 369.991 1.00 24.35 ? 123 GLU A OE2 1 
ATOM   412  N N   . PHE A 1 124 ? 221.282 274.065 364.086 1.00 13.58 ? 124 PHE A N   1 
ATOM   413  C CA  . PHE A 1 124 ? 220.311 273.301 363.316 1.00 10.57 ? 124 PHE A CA  1 
ATOM   414  C C   . PHE A 1 124 ? 220.935 272.055 362.709 1.00 6.61  ? 124 PHE A C   1 
ATOM   415  O O   . PHE A 1 124 ? 220.208 271.163 362.266 1.00 11.26 ? 124 PHE A O   1 
ATOM   416  C CB  . PHE A 1 124 ? 219.722 274.160 362.194 1.00 13.68 ? 124 PHE A CB  1 
ATOM   417  C CG  . PHE A 1 124 ? 218.460 274.875 362.566 1.00 13.28 ? 124 PHE A CG  1 
ATOM   418  C CD1 . PHE A 1 124 ? 218.504 276.116 363.176 1.00 15.03 ? 124 PHE A CD1 1 
ATOM   419  C CD2 . PHE A 1 124 ? 217.225 274.312 362.293 1.00 17.47 ? 124 PHE A CD2 1 
ATOM   420  C CE1 . PHE A 1 124 ? 217.346 276.775 363.513 1.00 13.68 ? 124 PHE A CE1 1 
ATOM   421  C CE2 . PHE A 1 124 ? 216.060 274.971 362.627 1.00 13.68 ? 124 PHE A CE2 1 
ATOM   422  C CZ  . PHE A 1 124 ? 216.121 276.204 363.234 1.00 12.18 ? 124 PHE A CZ  1 
ATOM   423  N N   . PHE A 1 125 ? 222.262 271.980 362.670 1.00 15.15 ? 125 PHE A N   1 
ATOM   424  C CA  . PHE A 1 125 ? 222.970 270.905 361.999 1.00 15.51 ? 125 PHE A CA  1 
ATOM   425  C C   . PHE A 1 125 ? 224.056 270.364 362.912 1.00 12.17 ? 125 PHE A C   1 
ATOM   426  O O   . PHE A 1 125 ? 224.471 271.011 363.873 1.00 17.09 ? 125 PHE A O   1 
ATOM   427  C CB  . PHE A 1 125 ? 223.574 271.389 360.679 1.00 12.58 ? 125 PHE A CB  1 
ATOM   428  C CG  . PHE A 1 125 ? 222.585 272.060 359.789 1.00 12.84 ? 125 PHE A CG  1 
ATOM   429  C CD1 . PHE A 1 125 ? 221.823 271.323 358.901 1.00 11.32 ? 125 PHE A CD1 1 
ATOM   430  C CD2 . PHE A 1 125 ? 222.395 273.430 359.851 1.00 17.30 ? 125 PHE A CD2 1 
ATOM   431  C CE1 . PHE A 1 125 ? 220.902 271.943 358.086 1.00 14.74 ? 125 PHE A CE1 1 
ATOM   432  C CE2 . PHE A 1 125 ? 221.476 274.048 359.040 1.00 8.60  ? 125 PHE A CE2 1 
ATOM   433  C CZ  . PHE A 1 125 ? 220.732 273.302 358.154 1.00 6.85  ? 125 PHE A CZ  1 
ATOM   434  N N   . THR A 1 126 ? 224.499 269.147 362.604 1.00 15.58 ? 126 THR A N   1 
ATOM   435  C CA  . THR A 1 126 ? 225.536 268.513 363.408 1.00 9.17  ? 126 THR A CA  1 
ATOM   436  C C   . THR A 1 126 ? 226.924 268.896 362.912 1.00 7.53  ? 126 THR A C   1 
ATOM   437  O O   . THR A 1 126 ? 227.797 269.244 363.711 1.00 12.43 ? 126 THR A O   1 
ATOM   438  C CB  . THR A 1 126 ? 225.370 266.991 363.387 1.00 10.57 ? 126 THR A CB  1 
ATOM   439  O OG1 . THR A 1 126 ? 223.985 266.655 363.506 1.00 21.36 ? 126 THR A OG1 1 
ATOM   440  C CG2 . THR A 1 126 ? 226.135 266.354 364.530 1.00 12.36 ? 126 THR A CG2 1 
ATOM   441  N N   . TYR A 1 127 ? 227.142 268.849 361.602 1.00 16.24 ? 127 TYR A N   1 
ATOM   442  C CA  . TYR A 1 127 ? 228.461 269.098 361.041 1.00 8.72  ? 127 TYR A CA  1 
ATOM   443  C C   . TYR A 1 127 ? 228.388 270.196 359.990 1.00 6.23  ? 127 TYR A C   1 
ATOM   444  O O   . TYR A 1 127 ? 227.353 270.390 359.353 1.00 17.37 ? 127 TYR A O   1 
ATOM   445  C CB  . TYR A 1 127 ? 229.048 267.829 360.419 1.00 13.99 ? 127 TYR A CB  1 
ATOM   446  C CG  . TYR A 1 127 ? 229.099 266.656 361.363 1.00 8.82  ? 127 TYR A CG  1 
ATOM   447  C CD1 . TYR A 1 127 ? 229.961 266.651 362.447 1.00 12.56 ? 127 TYR A CD1 1 
ATOM   448  C CD2 . TYR A 1 127 ? 228.286 265.549 361.168 1.00 18.77 ? 127 TYR A CD2 1 
ATOM   449  C CE1 . TYR A 1 127 ? 230.010 265.583 363.309 1.00 9.56  ? 127 TYR A CE1 1 
ATOM   450  C CE2 . TYR A 1 127 ? 228.332 264.475 362.024 1.00 13.34 ? 127 TYR A CE2 1 
ATOM   451  C CZ  . TYR A 1 127 ? 229.196 264.497 363.092 1.00 10.58 ? 127 TYR A CZ  1 
ATOM   452  O OH  . TYR A 1 127 ? 229.242 263.427 363.949 1.00 19.05 ? 127 TYR A OH  1 
ATOM   453  N N   . SER A 1 128 ? 229.500 270.907 359.806 1.00 12.62 ? 128 SER A N   1 
ATOM   454  C CA  . SER A 1 128 ? 229.546 271.981 358.826 1.00 10.77 ? 128 SER A CA  1 
ATOM   455  C C   . SER A 1 128 ? 230.965 272.192 358.320 1.00 8.60  ? 128 SER A C   1 
ATOM   456  O O   . SER A 1 128 ? 231.943 271.926 359.019 1.00 16.58 ? 128 SER A O   1 
ATOM   457  C CB  . SER A 1 128 ? 229.016 273.295 359.411 1.00 15.95 ? 128 SER A CB  1 
ATOM   458  O OG  . SER A 1 128 ? 229.874 273.772 360.428 1.00 23.02 ? 128 SER A OG  1 
ATOM   459  N N   . ARG A 1 129 ? 231.054 272.672 357.083 1.00 12.25 ? 129 ARG A N   1 
ATOM   460  C CA  . ARG A 1 129 ? 232.271 273.228 356.508 1.00 10.65 ? 129 ARG A CA  1 
ATOM   461  C C   . ARG A 1 129 ? 231.951 274.604 355.952 1.00 11.03 ? 129 ARG A C   1 
ATOM   462  O O   . ARG A 1 129 ? 230.878 274.804 355.376 1.00 13.90 ? 129 ARG A O   1 
ATOM   463  C CB  . ARG A 1 129 ? 232.831 272.358 355.383 1.00 15.49 ? 129 ARG A CB  1 
ATOM   464  C CG  . ARG A 1 129 ? 233.486 271.079 355.815 1.00 17.15 ? 129 ARG A CG  1 
ATOM   465  C CD  . ARG A 1 129 ? 233.806 270.239 354.603 1.00 16.08 ? 129 ARG A CD  1 
ATOM   466  N NE  . ARG A 1 129 ? 234.805 270.865 353.748 1.00 15.27 ? 129 ARG A NE  1 
ATOM   467  C CZ  . ARG A 1 129 ? 236.110 270.642 353.823 1.00 11.46 ? 129 ARG A CZ  1 
ATOM   468  N NH1 . ARG A 1 129 ? 236.625 269.829 354.731 1.00 13.91 ? 129 ARG A NH1 1 
ATOM   469  N NH2 . ARG A 1 129 ? 236.919 271.246 352.961 1.00 7.92  ? 129 ARG A NH2 1 
ATOM   470  N N   . PHE A 1 130 ? 232.880 275.542 356.106 1.00 18.83 ? 130 PHE A N   1 
ATOM   471  C CA  . PHE A 1 130 ? 232.722 276.852 355.490 1.00 18.67 ? 130 PHE A CA  1 
ATOM   472  C C   . PHE A 1 130 ? 233.980 277.674 355.715 1.00 9.67  ? 130 PHE A C   1 
ATOM   473  O O   . PHE A 1 130 ? 234.747 277.430 356.649 1.00 11.92 ? 130 PHE A O   1 
ATOM   474  C CB  . PHE A 1 130 ? 231.498 277.594 356.044 1.00 16.54 ? 130 PHE A CB  1 
ATOM   475  C CG  . PHE A 1 130 ? 231.424 277.617 357.545 1.00 17.43 ? 130 PHE A CG  1 
ATOM   476  C CD1 . PHE A 1 130 ? 232.243 278.448 358.281 1.00 12.80 ? 130 PHE A CD1 1 
ATOM   477  C CD2 . PHE A 1 130 ? 230.521 276.814 358.218 1.00 14.81 ? 130 PHE A CD2 1 
ATOM   478  C CE1 . PHE A 1 130 ? 232.170 278.471 359.656 1.00 14.14 ? 130 PHE A CE1 1 
ATOM   479  C CE2 . PHE A 1 130 ? 230.445 276.837 359.595 1.00 10.84 ? 130 PHE A CE2 1 
ATOM   480  C CZ  . PHE A 1 130 ? 231.268 277.665 360.313 1.00 12.75 ? 130 PHE A CZ  1 
ATOM   481  N N   . ASP A 1 131 ? 234.178 278.652 354.838 1.00 16.27 ? 131 ASP A N   1 
ATOM   482  C CA  . ASP A 1 131 ? 235.119 279.725 355.098 1.00 14.44 ? 131 ASP A CA  1 
ATOM   483  C C   . ASP A 1 131 ? 234.461 280.762 356.001 1.00 17.87 ? 131 ASP A C   1 
ATOM   484  O O   . ASP A 1 131 ? 233.240 280.832 356.110 1.00 20.69 ? 131 ASP A O   1 
ATOM   485  C CB  . ASP A 1 131 ? 235.573 280.369 353.792 1.00 12.79 ? 131 ASP A CB  1 
ATOM   486  C CG  . ASP A 1 131 ? 236.044 279.354 352.777 1.00 23.95 ? 131 ASP A CG  1 
ATOM   487  O OD1 . ASP A 1 131 ? 236.497 278.267 353.181 1.00 32.34 ? 131 ASP A OD1 1 
ATOM   488  O OD2 . ASP A 1 131 ? 235.965 279.644 351.568 1.00 27.37 ? 131 ASP A OD2 1 
ATOM   489  N N   . MET A 1 132 ? 235.278 281.566 356.662 1.00 14.37 ? 132 MET A N   1 
ATOM   490  C CA  . MET A 1 132 ? 234.771 282.556 357.599 1.00 19.93 ? 132 MET A CA  1 
ATOM   491  C C   . MET A 1 132 ? 235.242 283.942 357.191 1.00 16.01 ? 132 MET A C   1 
ATOM   492  O O   . MET A 1 132 ? 236.403 284.133 356.830 1.00 19.79 ? 132 MET A O   1 
ATOM   493  C CB  . MET A 1 132 ? 235.222 282.240 359.028 1.00 16.87 ? 132 MET A CB  1 
ATOM   494  C CG  . MET A 1 132 ? 234.781 283.254 360.068 1.00 17.27 ? 132 MET A CG  1 
ATOM   495  S SD  . MET A 1 132 ? 233.001 283.509 360.115 1.00 42.71 ? 132 MET A SD  1 
ATOM   496  C CE  . MET A 1 132 ? 232.423 281.886 360.590 1.00 23.91 ? 132 MET A CE  1 
ATOM   497  N N   . GLU A 1 133 ? 234.336 284.909 357.241 1.00 16.85 ? 133 GLU A N   1 
ATOM   498  C CA  . GLU A 1 133 ? 234.680 286.308 357.058 1.00 11.13 ? 133 GLU A CA  1 
ATOM   499  C C   . GLU A 1 133 ? 234.485 287.020 358.386 1.00 16.18 ? 133 GLU A C   1 
ATOM   500  O O   . GLU A 1 133 ? 233.405 286.943 358.980 1.00 21.79 ? 133 GLU A O   1 
ATOM   501  C CB  . GLU A 1 133 ? 233.824 286.951 355.968 1.00 14.53 ? 133 GLU A CB  1 
ATOM   502  C CG  . GLU A 1 133 ? 234.293 288.330 355.553 1.00 17.45 ? 133 GLU A CG  1 
ATOM   503  C CD  . GLU A 1 133 ? 233.387 288.964 354.520 1.00 23.27 ? 133 GLU A CD  1 
ATOM   504  O OE1 . GLU A 1 133 ? 232.211 289.225 354.837 1.00 26.43 ? 133 GLU A OE1 1 
ATOM   505  O OE2 . GLU A 1 133 ? 233.848 289.188 353.382 1.00 31.62 ? 133 GLU A OE2 1 
ATOM   506  N N   . LEU A 1 134 ? 235.535 287.681 358.858 1.00 11.35 ? 134 LEU A N   1 
ATOM   507  C CA  . LEU A 1 134 ? 235.503 288.444 360.095 1.00 11.09 ? 134 LEU A CA  1 
ATOM   508  C C   . LEU A 1 134 ? 235.517 289.925 359.761 1.00 12.92 ? 134 LEU A C   1 
ATOM   509  O O   . LEU A 1 134 ? 236.339 290.378 358.955 1.00 22.89 ? 134 LEU A O   1 
ATOM   510  C CB  . LEU A 1 134 ? 236.693 288.105 360.993 1.00 14.81 ? 134 LEU A CB  1 
ATOM   511  C CG  . LEU A 1 134 ? 236.802 286.678 361.528 1.00 18.39 ? 134 LEU A CG  1 
ATOM   512  C CD1 . LEU A 1 134 ? 237.955 286.584 362.509 1.00 16.90 ? 134 LEU A CD1 1 
ATOM   513  C CD2 . LEU A 1 134 ? 235.509 286.236 362.181 1.00 18.67 ? 134 LEU A CD2 1 
ATOM   514  N N   . THR A 1 135 ? 234.602 290.668 360.371 1.00 11.49 ? 135 THR A N   1 
ATOM   515  C CA  . THR A 1 135 ? 234.549 292.115 360.256 1.00 7.93  ? 135 THR A CA  1 
ATOM   516  C C   . THR A 1 135 ? 234.638 292.716 361.651 1.00 8.56  ? 135 THR A C   1 
ATOM   517  O O   . THR A 1 135 ? 234.053 292.197 362.600 1.00 20.86 ? 135 THR A O   1 
ATOM   518  C CB  . THR A 1 135 ? 233.269 292.579 359.547 1.00 8.24  ? 135 THR A CB  1 
ATOM   519  O OG1 . THR A 1 135 ? 233.134 291.888 358.301 1.00 11.50 ? 135 THR A OG1 1 
ATOM   520  C CG2 . THR A 1 135 ? 233.311 294.075 359.272 1.00 2.79  ? 135 THR A CG2 1 
ATOM   521  N N   . PHE A 1 136 ? 235.395 293.798 361.772 1.00 11.33 ? 136 PHE A N   1 
ATOM   522  C CA  . PHE A 1 136 ? 235.666 294.441 363.049 1.00 11.12 ? 136 PHE A CA  1 
ATOM   523  C C   . PHE A 1 136 ? 235.147 295.866 362.992 1.00 12.69 ? 136 PHE A C   1 
ATOM   524  O O   . PHE A 1 136 ? 235.610 296.665 362.170 1.00 25.81 ? 136 PHE A O   1 
ATOM   525  C CB  . PHE A 1 136 ? 237.161 294.427 363.365 1.00 15.97 ? 136 PHE A CB  1 
ATOM   526  C CG  . PHE A 1 136 ? 237.769 293.061 363.326 1.00 10.48 ? 136 PHE A CG  1 
ATOM   527  C CD1 . PHE A 1 136 ? 238.225 292.527 362.136 1.00 3.39  ? 136 PHE A CD1 1 
ATOM   528  C CD2 . PHE A 1 136 ? 237.877 292.304 364.478 1.00 11.80 ? 136 PHE A CD2 1 
ATOM   529  C CE1 . PHE A 1 136 ? 238.776 291.271 362.096 1.00 14.26 ? 136 PHE A CE1 1 
ATOM   530  C CE2 . PHE A 1 136 ? 238.433 291.047 364.442 1.00 15.52 ? 136 PHE A CE2 1 
ATOM   531  C CZ  . PHE A 1 136 ? 238.882 290.529 363.249 1.00 15.70 ? 136 PHE A CZ  1 
ATOM   532  N N   . VAL A 1 137 ? 234.193 296.175 363.864 1.00 14.30 ? 137 VAL A N   1 
ATOM   533  C CA  . VAL A 1 137 ? 233.641 297.518 364.002 1.00 7.65  ? 137 VAL A CA  1 
ATOM   534  C C   . VAL A 1 137 ? 234.188 298.094 365.298 1.00 16.31 ? 137 VAL A C   1 
ATOM   535  O O   . VAL A 1 137 ? 233.967 297.531 366.373 1.00 19.55 ? 137 VAL A O   1 
ATOM   536  C CB  . VAL A 1 137 ? 232.102 297.504 364.000 1.00 18.31 ? 137 VAL A CB  1 
ATOM   537  C CG1 . VAL A 1 137 ? 231.549 298.888 364.302 1.00 13.08 ? 137 VAL A CG1 1 
ATOM   538  C CG2 . VAL A 1 137 ? 231.574 297.001 362.667 1.00 10.64 ? 137 VAL A CG2 1 
ATOM   539  N N   . VAL A 1 138 ? 234.893 299.215 365.204 1.00 20.25 ? 138 VAL A N   1 
ATOM   540  C CA  . VAL A 1 138 ? 235.621 299.786 366.332 1.00 12.97 ? 138 VAL A CA  1 
ATOM   541  C C   . VAL A 1 138 ? 234.971 301.102 366.721 1.00 17.40 ? 138 VAL A C   1 
ATOM   542  O O   . VAL A 1 138 ? 234.751 301.969 365.869 1.00 19.90 ? 138 VAL A O   1 
ATOM   543  C CB  . VAL A 1 138 ? 237.107 299.991 365.992 1.00 19.37 ? 138 VAL A CB  1 
ATOM   544  C CG1 . VAL A 1 138 ? 237.872 300.469 367.216 1.00 14.65 ? 138 VAL A CG1 1 
ATOM   545  C CG2 . VAL A 1 138 ? 237.703 298.707 365.442 1.00 14.50 ? 138 VAL A CG2 1 
ATOM   546  N N   . THR A 1 139 ? 234.661 301.250 368.006 1.00 17.04 ? 139 THR A N   1 
ATOM   547  C CA  . THR A 1 139 ? 234.167 302.508 368.543 1.00 13.95 ? 139 THR A CA  1 
ATOM   548  C C   . THR A 1 139 ? 234.986 302.868 369.770 1.00 16.57 ? 139 THR A C   1 
ATOM   549  O O   . THR A 1 139 ? 235.558 301.999 370.424 1.00 24.79 ? 139 THR A O   1 
ATOM   550  C CB  . THR A 1 139 ? 232.671 302.442 368.909 1.00 15.87 ? 139 THR A CB  1 
ATOM   551  O OG1 . THR A 1 139 ? 232.453 301.433 369.901 1.00 20.52 ? 139 THR A OG1 1 
ATOM   552  C CG2 . THR A 1 139 ? 231.834 302.135 367.684 1.00 14.69 ? 139 THR A CG2 1 
ATOM   553  N N   . SER A 1 140 ? 235.050 304.161 370.070 1.00 21.20 ? 140 SER A N   1 
ATOM   554  C CA  . SER A 1 140 ? 235.859 304.633 371.180 1.00 20.90 ? 140 SER A CA  1 
ATOM   555  C C   . SER A 1 140 ? 235.244 305.905 371.739 1.00 21.12 ? 140 SER A C   1 
ATOM   556  O O   . SER A 1 140 ? 234.456 306.581 371.076 1.00 30.51 ? 140 SER A O   1 
ATOM   557  C CB  . SER A 1 140 ? 237.310 304.880 370.749 1.00 22.51 ? 140 SER A CB  1 
ATOM   558  O OG  . SER A 1 140 ? 238.130 305.164 371.865 1.00 26.01 ? 140 SER A OG  1 
ATOM   559  N N   . ASN A 1 141 ? 235.617 306.223 372.974 1.00 22.67 ? 141 ASN A N   1 
ATOM   560  C CA  . ASN A 1 141 ? 235.108 307.422 373.623 1.00 30.16 ? 141 ASN A CA  1 
ATOM   561  C C   . ASN A 1 141 ? 236.061 307.859 374.725 1.00 33.41 ? 141 ASN A C   1 
ATOM   562  O O   . ASN A 1 141 ? 236.831 307.061 375.271 1.00 40.18 ? 141 ASN A O   1 
ATOM   563  C CB  . ASN A 1 141 ? 233.699 307.200 374.190 1.00 34.12 ? 141 ASN A CB  1 
ATOM   564  C CG  . ASN A 1 141 ? 233.659 306.126 375.261 1.00 39.76 ? 141 ASN A CG  1 
ATOM   565  O OD1 . ASN A 1 141 ? 233.570 304.936 374.961 1.00 38.62 ? 141 ASN A OD1 1 
ATOM   566  N ND2 . ASN A 1 141 ? 233.717 306.542 376.518 1.00 39.92 ? 141 ASN A ND2 1 
ATOM   567  N N   . TYR A 1 142 ? 236.003 309.154 375.027 1.00 34.81 ? 142 TYR A N   1 
ATOM   568  C CA  . TYR A 1 142 ? 236.632 309.696 376.219 1.00 34.48 ? 142 TYR A CA  1 
ATOM   569  C C   . TYR A 1 142 ? 235.889 309.218 377.455 1.00 37.73 ? 142 TYR A C   1 
ATOM   570  O O   . TYR A 1 142 ? 234.694 308.915 377.408 1.00 40.30 ? 142 TYR A O   1 
ATOM   571  C CB  . TYR A 1 142 ? 236.635 311.225 376.195 1.00 33.42 ? 142 TYR A CB  1 
ATOM   572  C CG  . TYR A 1 142 ? 237.424 311.835 375.065 1.00 37.79 ? 142 TYR A CG  1 
ATOM   573  C CD1 . TYR A 1 142 ? 238.801 311.972 375.149 1.00 38.81 ? 142 TYR A CD1 1 
ATOM   574  C CD2 . TYR A 1 142 ? 236.791 312.288 373.918 1.00 36.52 ? 142 TYR A CD2 1 
ATOM   575  C CE1 . TYR A 1 142 ? 239.525 312.529 374.115 1.00 38.12 ? 142 TYR A CE1 1 
ATOM   576  C CE2 . TYR A 1 142 ? 237.505 312.845 372.885 1.00 36.34 ? 142 TYR A CE2 1 
ATOM   577  C CZ  . TYR A 1 142 ? 238.871 312.965 372.988 1.00 37.25 ? 142 TYR A CZ  1 
ATOM   578  O OH  . TYR A 1 142 ? 239.580 313.526 371.953 1.00 41.90 ? 142 TYR A OH  1 
ATOM   579  N N   . THR A 1 143 ? 236.606 309.164 378.572 1.00 44.80 ? 143 THR A N   1 
ATOM   580  C CA  . THR A 1 143 ? 235.999 308.777 379.837 1.00 45.98 ? 143 THR A CA  1 
ATOM   581  C C   . THR A 1 143 ? 235.582 309.975 380.678 1.00 47.70 ? 143 THR A C   1 
ATOM   582  O O   . THR A 1 143 ? 234.628 309.871 381.456 1.00 47.71 ? 143 THR A O   1 
ATOM   583  C CB  . THR A 1 143 ? 236.966 307.897 380.632 1.00 45.83 ? 143 THR A CB  1 
ATOM   584  O OG1 . THR A 1 143 ? 237.206 306.682 379.912 1.00 45.66 ? 143 THR A OG1 1 
ATOM   585  C CG2 . THR A 1 143 ? 236.391 307.565 381.999 1.00 47.67 ? 143 THR A CG2 1 
ATOM   586  N N   . ASP A 1 144 ? 236.261 311.111 380.538 1.00 53.34 ? 144 ASP A N   1 
ATOM   587  C CA  . ASP A 1 144 ? 235.964 312.302 381.316 1.00 55.19 ? 144 ASP A CA  1 
ATOM   588  C C   . ASP A 1 144 ? 235.722 313.492 380.398 1.00 58.82 ? 144 ASP A C   1 
ATOM   589  O O   . ASP A 1 144 ? 236.291 313.595 379.308 1.00 57.56 ? 144 ASP A O   1 
ATOM   590  C CB  . ASP A 1 144 ? 237.100 312.625 382.296 1.00 57.57 ? 144 ASP A CB  1 
ATOM   591  C CG  . ASP A 1 144 ? 236.830 312.109 383.697 1.00 61.11 ? 144 ASP A CG  1 
ATOM   592  O OD1 . ASP A 1 144 ? 235.793 311.445 383.906 1.00 59.66 ? 144 ASP A OD1 1 
ATOM   593  O OD2 . ASP A 1 144 ? 237.655 312.375 384.596 1.00 60.06 ? 144 ASP A OD2 1 
ATOM   594  N N   . ALA A 1 145 ? 234.865 314.396 380.860 1.00 62.94 ? 145 ALA A N   1 
ATOM   595  C CA  . ALA A 1 145 ? 234.514 315.589 380.109 1.00 63.18 ? 145 ALA A CA  1 
ATOM   596  C C   . ALA A 1 145 ? 235.629 316.622 380.195 1.00 63.49 ? 145 ALA A C   1 
ATOM   597  O O   . ALA A 1 145 ? 236.266 316.792 381.238 1.00 63.93 ? 145 ALA A O   1 
ATOM   598  C CB  . ALA A 1 145 ? 233.210 316.193 380.633 1.00 62.06 ? 145 ALA A CB  1 
ATOM   599  N N   . ASN A 1 146 ? 235.871 317.298 379.070 1.00 66.37 ? 146 ASN A N   1 
ATOM   600  C CA  . ASN A 1 146 ? 236.831 318.395 378.983 1.00 67.01 ? 146 ASN A CA  1 
ATOM   601  C C   . ASN A 1 146 ? 238.160 318.032 379.633 1.00 66.41 ? 146 ASN A C   1 
ATOM   602  O O   . ASN A 1 146 ? 238.892 318.913 380.095 1.00 66.03 ? 146 ASN A O   1 
ATOM   603  C CB  . ASN A 1 146 ? 236.257 319.671 379.619 1.00 66.64 ? 146 ASN A CB  1 
ATOM   604  C CG  . ASN A 1 146 ? 235.947 319.510 381.097 1.00 68.35 ? 146 ASN A CG  1 
ATOM   605  O OD1 . ASN A 1 146 ? 234.806 319.246 381.479 1.00 65.70 ? 146 ASN A OD1 1 
ATOM   606  N ND2 . ASN A 1 146 ? 236.965 319.661 381.936 1.00 67.13 ? 146 ASN A ND2 1 
ATOM   607  N N   . ASN A 1 147 ? 238.484 316.738 379.670 1.00 62.76 ? 147 ASN A N   1 
ATOM   608  C CA  . ASN A 1 147 ? 239.747 316.311 380.254 1.00 62.22 ? 147 ASN A CA  1 
ATOM   609  C C   . ASN A 1 147 ? 240.916 316.538 379.306 1.00 62.57 ? 147 ASN A C   1 
ATOM   610  O O   . ASN A 1 147 ? 242.072 316.473 379.739 1.00 63.52 ? 147 ASN A O   1 
ATOM   611  C CB  . ASN A 1 147 ? 239.674 314.834 380.649 1.00 63.66 ? 147 ASN A CB  1 
ATOM   612  C CG  . ASN A 1 147 ? 240.328 314.559 381.990 1.00 63.85 ? 147 ASN A CG  1 
ATOM   613  O OD1 . ASN A 1 147 ? 239.786 313.832 382.823 1.00 63.78 ? 147 ASN A OD1 1 
ATOM   614  N ND2 . ASN A 1 147 ? 241.496 315.150 382.209 1.00 63.07 ? 147 ASN A ND2 1 
ATOM   615  N N   . GLY A 1 148 ? 240.644 316.802 378.029 1.00 60.04 ? 148 GLY A N   1 
ATOM   616  C CA  . GLY A 1 148 ? 241.655 317.044 377.024 1.00 60.10 ? 148 GLY A CA  1 
ATOM   617  C C   . GLY A 1 148 ? 241.271 316.403 375.711 1.00 59.46 ? 148 GLY A C   1 
ATOM   618  O O   . GLY A 1 148 ? 240.194 315.815 375.566 1.00 56.54 ? 148 GLY A O   1 
ATOM   619  N N   . HIS A 1 149 ? 242.165 316.516 374.736 1.00 50.94 ? 149 HIS A N   1 
ATOM   620  C CA  . HIS A 1 149 ? 241.970 315.972 373.400 1.00 47.51 ? 149 HIS A CA  1 
ATOM   621  C C   . HIS A 1 149 ? 242.933 314.811 373.175 1.00 47.28 ? 149 HIS A C   1 
ATOM   622  O O   . HIS A 1 149 ? 243.875 314.598 373.941 1.00 47.61 ? 149 HIS A O   1 
ATOM   623  C CB  . HIS A 1 149 ? 242.170 317.070 372.347 1.00 47.99 ? 149 HIS A CB  1 
ATOM   624  C CG  . HIS A 1 149 ? 241.744 316.676 370.967 1.00 52.46 ? 149 HIS A CG  1 
ATOM   625  N ND1 . HIS A 1 149 ? 242.639 316.295 369.992 1.00 49.58 ? 149 HIS A ND1 1 
ATOM   626  C CD2 . HIS A 1 149 ? 240.518 316.610 370.398 1.00 52.70 ? 149 HIS A CD2 1 
ATOM   627  C CE1 . HIS A 1 149 ? 241.983 316.007 368.883 1.00 49.41 ? 149 HIS A CE1 1 
ATOM   628  N NE2 . HIS A 1 149 ? 240.694 316.190 369.102 1.00 53.46 ? 149 HIS A NE2 1 
ATOM   629  N N   . ALA A 1 150 ? 242.682 314.045 372.115 1.00 40.25 ? 150 ALA A N   1 
ATOM   630  C CA  . ALA A 1 150 ? 243.514 312.898 371.783 1.00 38.20 ? 150 ALA A CA  1 
ATOM   631  C C   . ALA A 1 150 ? 243.705 312.811 370.277 1.00 38.23 ? 150 ALA A C   1 
ATOM   632  O O   . ALA A 1 150 ? 242.829 313.199 369.501 1.00 40.96 ? 150 ALA A O   1 
ATOM   633  C CB  . ALA A 1 150 ? 242.902 311.592 372.301 1.00 39.31 ? 150 ALA A CB  1 
ATOM   634  N N   . LEU A 1 151 ? 244.860 312.294 369.873 1.00 32.19 ? 151 LEU A N   1 
ATOM   635  C CA  . LEU A 1 151 ? 245.145 312.041 368.470 1.00 28.38 ? 151 LEU A CA  1 
ATOM   636  C C   . LEU A 1 151 ? 244.557 310.698 368.048 1.00 27.42 ? 151 LEU A C   1 
ATOM   637  O O   . LEU A 1 151 ? 244.303 309.817 368.870 1.00 30.17 ? 151 LEU A O   1 
ATOM   638  C CB  . LEU A 1 151 ? 246.653 312.066 368.209 1.00 27.30 ? 151 LEU A CB  1 
ATOM   639  C CG  . LEU A 1 151 ? 247.354 313.415 368.396 1.00 28.33 ? 151 LEU A CG  1 
ATOM   640  C CD1 . LEU A 1 151 ? 248.837 313.289 368.134 1.00 27.92 ? 151 LEU A CD1 1 
ATOM   641  C CD2 . LEU A 1 151 ? 246.755 314.473 367.491 1.00 30.70 ? 151 LEU A CD2 1 
ATOM   642  N N   . ASN A 1 152 ? 244.336 310.555 366.744 1.00 22.46 ? 152 ASN A N   1 
ATOM   643  C CA  . ASN A 1 152 ? 243.647 309.380 366.228 1.00 16.45 ? 152 ASN A CA  1 
ATOM   644  C C   . ASN A 1 152 ? 244.409 308.111 366.588 1.00 19.50 ? 152 ASN A C   1 
ATOM   645  O O   . ASN A 1 152 ? 245.628 308.032 366.418 1.00 30.82 ? 152 ASN A O   1 
ATOM   646  C CB  . ASN A 1 152 ? 243.483 309.495 364.714 1.00 15.14 ? 152 ASN A CB  1 
ATOM   647  C CG  . ASN A 1 152 ? 242.347 308.647 364.188 1.00 21.89 ? 152 ASN A CG  1 
ATOM   648  O OD1 . ASN A 1 152 ? 241.192 308.859 364.542 1.00 27.56 ? 152 ASN A OD1 1 
ATOM   649  N ND2 . ASN A 1 152 ? 242.667 307.688 363.335 1.00 21.46 ? 152 ASN A ND2 1 
ATOM   650  N N   . GLN A 1 153 ? 243.683 307.114 367.083 1.00 18.68 ? 153 GLN A N   1 
ATOM   651  C CA  . GLN A 1 153 ? 244.286 305.895 367.601 1.00 19.57 ? 153 GLN A CA  1 
ATOM   652  C C   . GLN A 1 153 ? 244.459 304.847 366.512 1.00 20.11 ? 153 GLN A C   1 
ATOM   653  O O   . GLN A 1 153 ? 243.693 304.783 365.548 1.00 24.43 ? 153 GLN A O   1 
ATOM   654  C CB  . GLN A 1 153 ? 243.434 305.302 368.719 1.00 18.17 ? 153 GLN A CB  1 
ATOM   655  C CG  . GLN A 1 153 ? 243.443 306.080 370.008 1.00 22.65 ? 153 GLN A CG  1 
ATOM   656  C CD  . GLN A 1 153 ? 242.367 305.605 370.959 1.00 24.13 ? 153 GLN A CD  1 
ATOM   657  O OE1 . GLN A 1 153 ? 242.652 304.976 371.974 1.00 31.92 ? 153 GLN A OE1 1 
ATOM   658  N NE2 . GLN A 1 153 ? 241.118 305.898 370.628 1.00 26.77 ? 153 GLN A NE2 1 
ATOM   659  N N   . VAL A 1 154 ? 245.474 304.010 366.693 1.00 17.64 ? 154 VAL A N   1 
ATOM   660  C CA  . VAL A 1 154 ? 245.699 302.826 365.875 1.00 20.14 ? 154 VAL A CA  1 
ATOM   661  C C   . VAL A 1 154 ? 245.570 301.608 366.776 1.00 14.73 ? 154 VAL A C   1 
ATOM   662  O O   . VAL A 1 154 ? 246.070 301.603 367.906 1.00 21.68 ? 154 VAL A O   1 
ATOM   663  C CB  . VAL A 1 154 ? 247.076 302.867 365.181 1.00 20.17 ? 154 VAL A CB  1 
ATOM   664  C CG1 . VAL A 1 154 ? 247.328 301.590 364.393 1.00 17.08 ? 154 VAL A CG1 1 
ATOM   665  C CG2 . VAL A 1 154 ? 247.173 304.084 364.275 1.00 13.73 ? 154 VAL A CG2 1 
ATOM   666  N N   . TYR A 1 155 ? 244.878 300.588 366.285 1.00 12.05 ? 155 TYR A N   1 
ATOM   667  C CA  . TYR A 1 155 ? 244.621 299.363 367.026 1.00 18.54 ? 155 TYR A CA  1 
ATOM   668  C C   . TYR A 1 155 ? 245.331 298.208 366.341 1.00 14.13 ? 155 TYR A C   1 
ATOM   669  O O   . TYR A 1 155 ? 245.337 298.117 365.112 1.00 12.73 ? 155 TYR A O   1 
ATOM   670  C CB  . TYR A 1 155 ? 243.114 299.067 367.108 1.00 15.35 ? 155 TYR A CB  1 
ATOM   671  C CG  . TYR A 1 155 ? 242.304 300.151 367.780 1.00 18.73 ? 155 TYR A CG  1 
ATOM   672  C CD1 . TYR A 1 155 ? 242.003 301.334 367.115 1.00 18.45 ? 155 TYR A CD1 1 
ATOM   673  C CD2 . TYR A 1 155 ? 241.836 299.991 369.074 1.00 15.10 ? 155 TYR A CD2 1 
ATOM   674  C CE1 . TYR A 1 155 ? 241.270 302.324 367.723 1.00 11.39 ? 155 TYR A CE1 1 
ATOM   675  C CE2 . TYR A 1 155 ? 241.102 300.975 369.687 1.00 17.77 ? 155 TYR A CE2 1 
ATOM   676  C CZ  . TYR A 1 155 ? 240.822 302.141 369.009 1.00 17.74 ? 155 TYR A CZ  1 
ATOM   677  O OH  . TYR A 1 155 ? 240.088 303.122 369.621 1.00 22.89 ? 155 TYR A OH  1 
ATOM   678  N N   . GLN A 1 156 ? 245.934 297.330 367.137 1.00 17.71 ? 156 GLN A N   1 
ATOM   679  C CA  . GLN A 1 156 ? 246.511 296.090 366.638 1.00 15.53 ? 156 GLN A CA  1 
ATOM   680  C C   . GLN A 1 156 ? 245.656 294.917 367.093 1.00 16.73 ? 156 GLN A C   1 
ATOM   681  O O   . GLN A 1 156 ? 245.343 294.792 368.284 1.00 20.44 ? 156 GLN A O   1 
ATOM   682  C CB  . GLN A 1 156 ? 247.952 295.904 367.119 1.00 11.82 ? 156 GLN A CB  1 
ATOM   683  C CG  . GLN A 1 156 ? 248.649 294.713 366.474 1.00 12.18 ? 156 GLN A CG  1 
ATOM   684  C CD  . GLN A 1 156 ? 250.048 294.481 367.006 1.00 16.81 ? 156 GLN A CD  1 
ATOM   685  O OE1 . GLN A 1 156 ? 250.515 295.194 367.884 1.00 16.91 ? 156 GLN A OE1 1 
ATOM   686  N NE2 . GLN A 1 156 ? 250.722 293.475 366.470 1.00 19.13 ? 156 GLN A NE2 1 
ATOM   687  N N   . ILE A 1 157 ? 245.277 294.074 366.136 1.00 8.32  ? 157 ILE A N   1 
ATOM   688  C CA  . ILE A 1 157 ? 244.583 292.817 366.378 1.00 13.78 ? 157 ILE A CA  1 
ATOM   689  C C   . ILE A 1 157 ? 245.485 291.709 365.851 1.00 14.38 ? 157 ILE A C   1 
ATOM   690  O O   . ILE A 1 157 ? 245.680 291.584 364.639 1.00 15.93 ? 157 ILE A O   1 
ATOM   691  C CB  . ILE A 1 157 ? 243.212 292.777 365.690 1.00 23.23 ? 157 ILE A CB  1 
ATOM   692  C CG1 . ILE A 1 157 ? 242.354 293.974 366.108 1.00 20.33 ? 157 ILE A CG1 1 
ATOM   693  C CG2 . ILE A 1 157 ? 242.502 291.462 365.997 1.00 15.09 ? 157 ILE A CG2 1 
ATOM   694  C CD1 . ILE A 1 157 ? 241.130 294.175 365.242 1.00 15.69 ? 157 ILE A CD1 1 
ATOM   695  N N   . MET A 1 158 ? 246.028 290.898 366.748 1.00 16.56 ? 158 MET A N   1 
ATOM   696  C CA  . MET A 1 158 ? 246.948 289.829 366.391 1.00 14.62 ? 158 MET A CA  1 
ATOM   697  C C   . MET A 1 158 ? 246.272 288.485 366.619 1.00 17.73 ? 158 MET A C   1 
ATOM   698  O O   . MET A 1 158 ? 245.765 288.218 367.711 1.00 13.23 ? 158 MET A O   1 
ATOM   699  C CB  . MET A 1 158 ? 248.237 289.926 367.213 1.00 15.81 ? 158 MET A CB  1 
ATOM   700  C CG  . MET A 1 158 ? 249.281 288.874 366.865 1.00 15.23 ? 158 MET A CG  1 
ATOM   701  S SD  . MET A 1 158 ? 250.902 289.190 367.589 1.00 16.72 ? 158 MET A SD  1 
ATOM   702  C CE  . MET A 1 158 ? 250.519 289.186 369.336 1.00 16.87 ? 158 MET A CE  1 
ATOM   703  N N   . TYR A 1 159 ? 246.262 287.648 365.588 1.00 19.45 ? 159 TYR A N   1 
ATOM   704  C CA  . TYR A 1 159 ? 245.784 286.281 365.725 1.00 17.21 ? 159 TYR A CA  1 
ATOM   705  C C   . TYR A 1 159 ? 246.871 285.432 366.362 1.00 11.08 ? 159 TYR A C   1 
ATOM   706  O O   . TYR A 1 159 ? 247.998 285.379 365.863 1.00 16.68 ? 159 TYR A O   1 
ATOM   707  C CB  . TYR A 1 159 ? 245.386 285.711 364.369 1.00 14.63 ? 159 TYR A CB  1 
ATOM   708  C CG  . TYR A 1 159 ? 245.009 284.247 364.389 1.00 18.93 ? 159 TYR A CG  1 
ATOM   709  C CD1 . TYR A 1 159 ? 244.316 283.701 365.460 1.00 21.27 ? 159 TYR A CD1 1 
ATOM   710  C CD2 . TYR A 1 159 ? 245.326 283.418 363.326 1.00 18.59 ? 159 TYR A CD2 1 
ATOM   711  C CE1 . TYR A 1 159 ? 243.967 282.375 365.476 1.00 13.86 ? 159 TYR A CE1 1 
ATOM   712  C CE2 . TYR A 1 159 ? 244.976 282.091 363.332 1.00 13.92 ? 159 TYR A CE2 1 
ATOM   713  C CZ  . TYR A 1 159 ? 244.297 281.573 364.409 1.00 13.42 ? 159 TYR A CZ  1 
ATOM   714  O OH  . TYR A 1 159 ? 243.949 280.246 364.417 1.00 25.62 ? 159 TYR A OH  1 
ATOM   715  N N   . ILE A 1 160 ? 246.529 284.769 367.459 1.00 21.77 ? 160 ILE A N   1 
ATOM   716  C CA  . ILE A 1 160 ? 247.447 283.888 368.168 1.00 17.72 ? 160 ILE A CA  1 
ATOM   717  C C   . ILE A 1 160 ? 246.912 282.472 368.005 1.00 17.84 ? 160 ILE A C   1 
ATOM   718  O O   . ILE A 1 160 ? 246.015 282.060 368.754 1.00 21.09 ? 160 ILE A O   1 
ATOM   719  C CB  . ILE A 1 160 ? 247.569 284.286 369.646 1.00 18.38 ? 160 ILE A CB  1 
ATOM   720  C CG1 . ILE A 1 160 ? 247.973 285.759 369.759 1.00 22.25 ? 160 ILE A CG1 1 
ATOM   721  C CG2 . ILE A 1 160 ? 248.583 283.403 370.358 1.00 16.62 ? 160 ILE A CG2 1 
ATOM   722  C CD1 . ILE A 1 160 ? 247.866 286.317 371.145 1.00 24.20 ? 160 ILE A CD1 1 
ATOM   723  N N   . PRO A 1 161 ? 247.406 281.704 367.039 1.00 21.20 ? 161 PRO A N   1 
ATOM   724  C CA  . PRO A 1 161 ? 246.960 280.319 366.896 1.00 17.58 ? 161 PRO A CA  1 
ATOM   725  C C   . PRO A 1 161 ? 247.381 279.499 368.099 1.00 13.94 ? 161 PRO A C   1 
ATOM   726  O O   . PRO A 1 161 ? 248.342 279.859 368.795 1.00 18.86 ? 161 PRO A O   1 
ATOM   727  C CB  . PRO A 1 161 ? 247.669 279.845 365.618 1.00 14.06 ? 161 PRO A CB  1 
ATOM   728  C CG  . PRO A 1 161 ? 248.077 281.080 364.914 1.00 18.60 ? 161 PRO A CG  1 
ATOM   729  C CD  . PRO A 1 161 ? 248.340 282.091 365.972 1.00 17.25 ? 161 PRO A CD  1 
ATOM   730  N N   . PRO A 1 162 ? 246.685 278.404 368.393 1.00 27.12 ? 162 PRO A N   1 
ATOM   731  C CA  . PRO A 1 162 ? 247.027 277.623 369.588 1.00 20.75 ? 162 PRO A CA  1 
ATOM   732  C C   . PRO A 1 162 ? 248.480 277.171 369.548 1.00 19.24 ? 162 PRO A C   1 
ATOM   733  O O   . PRO A 1 162 ? 248.938 276.575 368.572 1.00 22.78 ? 162 PRO A O   1 
ATOM   734  C CB  . PRO A 1 162 ? 246.051 276.443 369.537 1.00 13.41 ? 162 PRO A CB  1 
ATOM   735  C CG  . PRO A 1 162 ? 245.587 276.373 368.133 1.00 18.38 ? 162 PRO A CG  1 
ATOM   736  C CD  . PRO A 1 162 ? 245.636 277.757 367.588 1.00 18.79 ? 162 PRO A CD  1 
ATOM   737  N N   . GLY A 1 163 ? 249.211 277.480 370.620 1.00 18.96 ? 163 GLY A N   1 
ATOM   738  C CA  . GLY A 1 163 ? 250.617 277.166 370.745 1.00 17.78 ? 163 GLY A CA  1 
ATOM   739  C C   . GLY A 1 163 ? 251.527 278.375 370.654 1.00 17.24 ? 163 GLY A C   1 
ATOM   740  O O   . GLY A 1 163 ? 252.611 278.365 371.245 1.00 27.56 ? 163 GLY A O   1 
ATOM   741  N N   . ALA A 1 164 ? 251.109 279.413 369.940 1.00 19.19 ? 164 ALA A N   1 
ATOM   742  C CA  . ALA A 1 164 ? 251.920 280.612 369.848 1.00 17.39 ? 164 ALA A CA  1 
ATOM   743  C C   . ALA A 1 164 ? 251.992 281.306 371.207 1.00 20.16 ? 164 ALA A C   1 
ATOM   744  O O   . ALA A 1 164 ? 251.071 281.197 372.018 1.00 25.37 ? 164 ALA A O   1 
ATOM   745  C CB  . ALA A 1 164 ? 251.351 281.566 368.804 1.00 19.07 ? 164 ALA A CB  1 
ATOM   746  N N   . PRO A 1 165 ? 253.087 282.010 371.490 1.00 20.07 ? 165 PRO A N   1 
ATOM   747  C CA  . PRO A 1 165 ? 253.179 282.729 372.766 1.00 21.88 ? 165 PRO A CA  1 
ATOM   748  C C   . PRO A 1 165 ? 252.086 283.780 372.891 1.00 23.26 ? 165 PRO A C   1 
ATOM   749  O O   . PRO A 1 165 ? 251.744 284.466 371.928 1.00 28.47 ? 165 PRO A O   1 
ATOM   750  C CB  . PRO A 1 165 ? 254.575 283.359 372.721 1.00 21.39 ? 165 PRO A CB  1 
ATOM   751  C CG  . PRO A 1 165 ? 254.947 283.384 371.288 1.00 19.77 ? 165 PRO A CG  1 
ATOM   752  C CD  . PRO A 1 165 ? 254.286 282.206 370.660 1.00 18.03 ? 165 PRO A CD  1 
ATOM   753  N N   . ILE A 1 166 ? 251.550 283.906 374.095 1.00 26.57 ? 166 ILE A N   1 
ATOM   754  C CA  . ILE A 1 166 ? 250.434 284.804 374.380 1.00 23.36 ? 166 ILE A CA  1 
ATOM   755  C C   . ILE A 1 166 ? 250.987 286.066 375.031 1.00 27.63 ? 166 ILE A C   1 
ATOM   756  O O   . ILE A 1 166 ? 251.783 285.959 375.973 1.00 30.04 ? 166 ILE A O   1 
ATOM   757  C CB  . ILE A 1 166 ? 249.390 284.130 375.289 1.00 24.67 ? 166 ILE A CB  1 
ATOM   758  C CG1 . ILE A 1 166 ? 248.675 283.017 374.522 1.00 26.53 ? 166 ILE A CG1 1 
ATOM   759  C CG2 . ILE A 1 166 ? 248.390 285.150 375.807 1.00 26.75 ? 166 ILE A CG2 1 
ATOM   760  C CD1 . ILE A 1 166 ? 247.854 282.102 375.391 1.00 29.27 ? 166 ILE A CD1 1 
ATOM   761  N N   . PRO A 1 167 ? 250.611 287.258 374.567 1.00 24.86 ? 167 PRO A N   1 
ATOM   762  C CA  . PRO A 1 167 ? 251.096 288.483 375.212 1.00 22.20 ? 167 PRO A CA  1 
ATOM   763  C C   . PRO A 1 167 ? 250.737 288.523 376.689 1.00 22.64 ? 167 PRO A C   1 
ATOM   764  O O   . PRO A 1 167 ? 249.645 288.123 377.094 1.00 25.38 ? 167 PRO A O   1 
ATOM   765  C CB  . PRO A 1 167 ? 250.389 289.596 374.432 1.00 21.89 ? 167 PRO A CB  1 
ATOM   766  C CG  . PRO A 1 167 ? 250.078 289.003 373.119 1.00 21.03 ? 167 PRO A CG  1 
ATOM   767  C CD  . PRO A 1 167 ? 249.823 287.552 373.357 1.00 17.97 ? 167 PRO A CD  1 
ATOM   768  N N   . GLY A 1 168 ? 251.669 289.024 377.493 1.00 24.99 ? 168 GLY A N   1 
ATOM   769  C CA  . GLY A 1 168 ? 251.447 289.177 378.915 1.00 23.10 ? 168 GLY A CA  1 
ATOM   770  C C   . GLY A 1 168 ? 251.476 290.627 379.338 1.00 27.87 ? 168 GLY A C   1 
ATOM   771  O O   . GLY A 1 168 ? 251.048 290.972 380.442 1.00 31.68 ? 168 GLY A O   1 
ATOM   772  N N   . LYS A 1 169 ? 251.977 291.488 378.457 1.00 30.85 ? 169 LYS A N   1 
ATOM   773  C CA  . LYS A 1 169 ? 252.037 292.918 378.703 1.00 22.28 ? 169 LYS A CA  1 
ATOM   774  C C   . LYS A 1 169 ? 251.734 293.651 377.408 1.00 26.14 ? 169 LYS A C   1 
ATOM   775  O O   . LYS A 1 169 ? 251.796 293.080 376.317 1.00 27.89 ? 169 LYS A O   1 
ATOM   776  C CB  . LYS A 1 169 ? 253.404 293.344 379.248 1.00 26.33 ? 169 LYS A CB  1 
ATOM   777  C CG  . LYS A 1 169 ? 253.583 293.065 380.725 1.00 31.73 ? 169 LYS A CG  1 
ATOM   778  C CD  . LYS A 1 169 ? 255.041 293.143 381.143 1.00 34.70 ? 169 LYS A CD  1 
ATOM   779  C CE  . LYS A 1 169 ? 255.221 292.666 382.578 1.00 35.32 ? 169 LYS A CE  1 
ATOM   780  N NZ  . LYS A 1 169 ? 256.653 292.603 382.985 1.00 34.37 ? 169 LYS A NZ  1 
ATOM   781  N N   . TRP A 1 170 ? 251.389 294.931 377.545 1.00 32.76 ? 170 TRP A N   1 
ATOM   782  C CA  . TRP A 1 170 ? 251.076 295.741 376.374 1.00 28.29 ? 170 TRP A CA  1 
ATOM   783  C C   . TRP A 1 170 ? 252.263 295.842 375.424 1.00 29.51 ? 170 TRP A C   1 
ATOM   784  O O   . TRP A 1 170 ? 252.075 295.918 374.205 1.00 28.70 ? 170 TRP A O   1 
ATOM   785  C CB  . TRP A 1 170 ? 250.626 297.136 376.814 1.00 25.93 ? 170 TRP A CB  1 
ATOM   786  C CG  . TRP A 1 170 ? 250.433 298.085 375.674 1.00 28.01 ? 170 TRP A CG  1 
ATOM   787  C CD1 . TRP A 1 170 ? 249.338 298.187 374.873 1.00 28.21 ? 170 TRP A CD1 1 
ATOM   788  C CD2 . TRP A 1 170 ? 251.365 299.064 375.206 1.00 31.11 ? 170 TRP A CD2 1 
ATOM   789  N NE1 . TRP A 1 170 ? 249.528 299.166 373.933 1.00 27.29 ? 170 TRP A NE1 1 
ATOM   790  C CE2 . TRP A 1 170 ? 250.767 299.720 374.115 1.00 30.99 ? 170 TRP A CE2 1 
ATOM   791  C CE3 . TRP A 1 170 ? 252.649 299.447 375.602 1.00 31.79 ? 170 TRP A CE3 1 
ATOM   792  C CZ2 . TRP A 1 170 ? 251.407 300.741 373.416 1.00 26.22 ? 170 TRP A CZ2 1 
ATOM   793  C CZ3 . TRP A 1 170 ? 253.282 300.458 374.906 1.00 31.56 ? 170 TRP A CZ3 1 
ATOM   794  C CH2 . TRP A 1 170 ? 252.660 301.094 373.826 1.00 26.49 ? 170 TRP A CH2 1 
ATOM   795  N N   . ASN A 1 171 ? 253.485 295.836 375.955 1.00 27.09 ? 171 ASN A N   1 
ATOM   796  C CA  . ASN A 1 171 ? 254.683 296.127 375.176 1.00 26.21 ? 171 ASN A CA  1 
ATOM   797  C C   . ASN A 1 171 ? 255.591 294.919 374.985 1.00 27.66 ? 171 ASN A C   1 
ATOM   798  O O   . ASN A 1 171 ? 256.735 295.090 374.555 1.00 37.70 ? 171 ASN A O   1 
ATOM   799  C CB  . ASN A 1 171 ? 255.474 297.252 375.844 1.00 31.12 ? 171 ASN A CB  1 
ATOM   800  C CG  . ASN A 1 171 ? 256.042 296.846 377.188 1.00 33.06 ? 171 ASN A CG  1 
ATOM   801  O OD1 . ASN A 1 171 ? 255.513 295.959 377.855 1.00 36.95 ? 171 ASN A OD1 1 
ATOM   802  N ND2 . ASN A 1 171 ? 257.125 297.492 377.592 1.00 36.08 ? 171 ASN A ND2 1 
ATOM   803  N N   . ASP A 1 172 ? 255.129 293.712 375.293 1.00 22.08 ? 172 ASP A N   1 
ATOM   804  C CA  . ASP A 1 172 ? 256.013 292.560 375.219 1.00 24.80 ? 172 ASP A CA  1 
ATOM   805  C C   . ASP A 1 172 ? 256.359 292.240 373.764 1.00 23.43 ? 172 ASP A C   1 
ATOM   806  O O   . ASP A 1 172 ? 255.682 292.661 372.825 1.00 26.74 ? 172 ASP A O   1 
ATOM   807  C CB  . ASP A 1 172 ? 255.380 291.350 375.909 1.00 23.65 ? 172 ASP A CB  1 
ATOM   808  C CG  . ASP A 1 172 ? 254.469 290.565 375.002 1.00 31.97 ? 172 ASP A CG  1 
ATOM   809  O OD1 . ASP A 1 172 ? 253.483 291.139 374.500 1.00 36.61 ? 172 ASP A OD1 1 
ATOM   810  O OD2 . ASP A 1 172 ? 254.744 289.370 374.781 1.00 26.46 ? 172 ASP A OD2 1 
ATOM   811  N N   . TYR A 1 173 ? 257.439 291.478 373.591 1.00 28.79 ? 173 TYR A N   1 
ATOM   812  C CA  . TYR A 1 173 ? 257.993 291.224 372.265 1.00 23.32 ? 173 TYR A CA  1 
ATOM   813  C C   . TYR A 1 173 ? 257.008 290.538 371.327 1.00 23.39 ? 173 TYR A C   1 
ATOM   814  O O   . TYR A 1 173 ? 257.153 290.656 370.106 1.00 29.70 ? 173 TYR A O   1 
ATOM   815  C CB  . TYR A 1 173 ? 259.251 290.362 372.390 1.00 23.28 ? 173 TYR A CB  1 
ATOM   816  C CG  . TYR A 1 173 ? 258.947 288.934 372.780 1.00 24.74 ? 173 TYR A CG  1 
ATOM   817  C CD1 . TYR A 1 173 ? 258.626 288.608 374.087 1.00 23.51 ? 173 TYR A CD1 1 
ATOM   818  C CD2 . TYR A 1 173 ? 258.963 287.917 371.837 1.00 23.08 ? 173 TYR A CD2 1 
ATOM   819  C CE1 . TYR A 1 173 ? 258.337 287.317 374.446 1.00 22.06 ? 173 TYR A CE1 1 
ATOM   820  C CE2 . TYR A 1 173 ? 258.670 286.621 372.186 1.00 21.86 ? 173 TYR A CE2 1 
ATOM   821  C CZ  . TYR A 1 173 ? 258.362 286.325 373.494 1.00 26.93 ? 173 TYR A CZ  1 
ATOM   822  O OH  . TYR A 1 173 ? 258.073 285.032 373.858 1.00 31.67 ? 173 TYR A OH  1 
ATOM   823  N N   . THR A 1 174 ? 256.014 289.824 371.860 1.00 17.27 ? 174 THR A N   1 
ATOM   824  C CA  . THR A 1 174 ? 255.130 289.039 371.003 1.00 19.72 ? 174 THR A CA  1 
ATOM   825  C C   . THR A 1 174 ? 254.429 289.905 369.964 1.00 19.74 ? 174 THR A C   1 
ATOM   826  O O   . THR A 1 174 ? 254.075 289.411 368.889 1.00 18.11 ? 174 THR A O   1 
ATOM   827  C CB  . THR A 1 174 ? 254.094 288.293 371.847 1.00 21.59 ? 174 THR A CB  1 
ATOM   828  O OG1 . THR A 1 174 ? 253.376 289.221 372.667 1.00 19.88 ? 174 THR A OG1 1 
ATOM   829  C CG2 . THR A 1 174 ? 254.767 287.255 372.726 1.00 23.85 ? 174 THR A CG2 1 
ATOM   830  N N   . TRP A 1 175 ? 254.237 291.192 370.252 1.00 23.64 ? 175 TRP A N   1 
ATOM   831  C CA  . TRP A 1 175 ? 253.533 292.062 369.318 1.00 15.27 ? 175 TRP A CA  1 
ATOM   832  C C   . TRP A 1 175 ? 254.318 292.304 368.035 1.00 17.46 ? 175 TRP A C   1 
ATOM   833  O O   . TRP A 1 175 ? 253.753 292.837 367.077 1.00 27.23 ? 175 TRP A O   1 
ATOM   834  C CB  . TRP A 1 175 ? 253.206 293.395 369.984 1.00 16.14 ? 175 TRP A CB  1 
ATOM   835  C CG  . TRP A 1 175 ? 252.252 293.271 371.135 1.00 21.34 ? 175 TRP A CG  1 
ATOM   836  C CD1 . TRP A 1 175 ? 252.549 293.389 372.455 1.00 22.92 ? 175 TRP A CD1 1 
ATOM   837  C CD2 . TRP A 1 175 ? 250.847 292.997 371.063 1.00 20.51 ? 175 TRP A CD2 1 
ATOM   838  N NE1 . TRP A 1 175 ? 251.421 293.214 373.213 1.00 21.32 ? 175 TRP A NE1 1 
ATOM   839  C CE2 . TRP A 1 175 ? 250.361 292.970 372.382 1.00 17.74 ? 175 TRP A CE2 1 
ATOM   840  C CE3 . TRP A 1 175 ? 249.954 292.774 370.011 1.00 20.08 ? 175 TRP A CE3 1 
ATOM   841  C CZ2 . TRP A 1 175 ? 249.020 292.733 372.678 1.00 17.37 ? 175 TRP A CZ2 1 
ATOM   842  C CZ3 . TRP A 1 175 ? 248.626 292.538 370.308 1.00 16.84 ? 175 TRP A CZ3 1 
ATOM   843  C CH2 . TRP A 1 175 ? 248.172 292.518 371.630 1.00 11.77 ? 175 TRP A CH2 1 
ATOM   844  N N   . GLN A 1 176 ? 255.599 291.927 367.987 1.00 20.37 ? 176 GLN A N   1 
ATOM   845  C CA  . GLN A 1 176 ? 256.359 292.047 366.747 1.00 12.00 ? 176 GLN A CA  1 
ATOM   846  C C   . GLN A 1 176 ? 255.756 291.218 365.622 1.00 19.37 ? 176 GLN A C   1 
ATOM   847  O O   . GLN A 1 176 ? 256.003 291.515 364.449 1.00 21.26 ? 176 GLN A O   1 
ATOM   848  C CB  . GLN A 1 176 ? 257.812 291.632 366.977 1.00 19.12 ? 176 GLN A CB  1 
ATOM   849  C CG  . GLN A 1 176 ? 258.587 292.588 367.857 1.00 21.58 ? 176 GLN A CG  1 
ATOM   850  C CD  . GLN A 1 176 ? 259.880 291.989 368.377 1.00 30.78 ? 176 GLN A CD  1 
ATOM   851  O OE1 . GLN A 1 176 ? 260.297 290.912 367.951 1.00 22.97 ? 176 GLN A OE1 1 
ATOM   852  N NE2 . GLN A 1 176 ? 260.516 292.684 369.308 1.00 28.19 ? 176 GLN A NE2 1 
ATOM   853  N N   . THR A 1 177 ? 254.990 290.181 365.956 1.00 17.84 ? 177 THR A N   1 
ATOM   854  C CA  . THR A 1 177 ? 254.141 289.444 365.014 1.00 19.82 ? 177 THR A CA  1 
ATOM   855  C C   . THR A 1 177 ? 254.887 289.077 363.731 1.00 18.87 ? 177 THR A C   1 
ATOM   856  O O   . THR A 1 177 ? 254.415 289.304 362.616 1.00 25.59 ? 177 THR A O   1 
ATOM   857  C CB  . THR A 1 177 ? 252.859 290.232 364.702 1.00 22.37 ? 177 THR A CB  1 
ATOM   858  O OG1 . THR A 1 177 ? 251.992 289.442 363.880 1.00 26.37 ? 177 THR A OG1 1 
ATOM   859  C CG2 . THR A 1 177 ? 253.146 291.561 363.993 1.00 12.91 ? 177 THR A CG2 1 
ATOM   860  N N   . SER A 1 178 ? 256.062 288.467 363.895 1.00 12.48 ? 178 SER A N   1 
ATOM   861  C CA  . SER A 1 178 ? 256.844 288.077 362.727 1.00 14.38 ? 178 SER A CA  1 
ATOM   862  C C   . SER A 1 178 ? 256.150 286.974 361.937 1.00 13.37 ? 178 SER A C   1 
ATOM   863  O O   . SER A 1 178 ? 256.217 286.954 360.704 1.00 17.06 ? 178 SER A O   1 
ATOM   864  C CB  . SER A 1 178 ? 258.243 287.630 363.148 1.00 14.53 ? 178 SER A CB  1 
ATOM   865  O OG  . SER A 1 178 ? 258.252 286.271 363.541 1.00 24.02 ? 178 SER A OG  1 
ATOM   866  N N   . SER A 1 179 ? 255.490 286.046 362.623 1.00 23.24 ? 179 SER A N   1 
ATOM   867  C CA  . SER A 1 179 ? 254.803 284.937 361.974 1.00 13.32 ? 179 SER A CA  1 
ATOM   868  C C   . SER A 1 179 ? 253.302 284.935 362.199 1.00 14.63 ? 179 SER A C   1 
ATOM   869  O O   . SER A 1 179 ? 252.576 284.380 361.375 1.00 23.92 ? 179 SER A O   1 
ATOM   870  C CB  . SER A 1 179 ? 255.375 283.597 362.460 1.00 17.09 ? 179 SER A CB  1 
ATOM   871  O OG  . SER A 1 179 ? 256.780 283.558 362.315 1.00 19.75 ? 179 SER A OG  1 
ATOM   872  N N   . ASN A 1 180 ? 252.823 285.525 363.287 1.00 22.39 ? 180 ASN A N   1 
ATOM   873  C CA  . ASN A 1 180 ? 251.388 285.641 363.500 1.00 15.94 ? 180 ASN A CA  1 
ATOM   874  C C   . ASN A 1 180 ? 250.792 286.645 362.516 1.00 11.79 ? 180 ASN A C   1 
ATOM   875  O O   . ASN A 1 180 ? 251.357 287.723 362.316 1.00 18.23 ? 180 ASN A O   1 
ATOM   876  C CB  . ASN A 1 180 ? 251.090 286.098 364.927 1.00 15.08 ? 180 ASN A CB  1 
ATOM   877  C CG  . ASN A 1 180 ? 251.355 285.026 365.951 1.00 10.73 ? 180 ASN A CG  1 
ATOM   878  O OD1 . ASN A 1 180 ? 251.793 283.931 365.618 1.00 20.33 ? 180 ASN A OD1 1 
ATOM   879  N ND2 . ASN A 1 180 ? 251.094 285.339 367.210 1.00 17.78 ? 180 ASN A ND2 1 
ATOM   880  N N   . PRO A 1 181 ? 249.659 286.330 361.889 1.00 20.30 ? 181 PRO A N   1 
ATOM   881  C CA  . PRO A 1 181 ? 248.932 287.368 361.151 1.00 20.01 ? 181 PRO A CA  1 
ATOM   882  C C   . PRO A 1 181 ? 248.481 288.472 362.094 1.00 17.82 ? 181 PRO A C   1 
ATOM   883  O O   . PRO A 1 181 ? 248.069 288.218 363.226 1.00 20.80 ? 181 PRO A O   1 
ATOM   884  C CB  . PRO A 1 181 ? 247.741 286.615 360.546 1.00 12.66 ? 181 PRO A CB  1 
ATOM   885  C CG  . PRO A 1 181 ? 248.102 285.182 360.612 1.00 14.04 ? 181 PRO A CG  1 
ATOM   886  C CD  . PRO A 1 181 ? 248.986 285.025 361.798 1.00 19.61 ? 181 PRO A CD  1 
ATOM   887  N N   . SER A 1 182 ? 248.566 289.707 361.622 1.00 17.23 ? 182 SER A N   1 
ATOM   888  C CA  . SER A 1 182 ? 248.186 290.859 362.419 1.00 5.93  ? 182 SER A CA  1 
ATOM   889  C C   . SER A 1 182 ? 247.473 291.869 361.535 1.00 13.25 ? 182 SER A C   1 
ATOM   890  O O   . SER A 1 182 ? 247.680 291.919 360.322 1.00 17.64 ? 182 SER A O   1 
ATOM   891  C CB  . SER A 1 182 ? 249.395 291.505 363.090 1.00 12.49 ? 182 SER A CB  1 
ATOM   892  O OG  . SER A 1 182 ? 248.996 292.406 364.100 1.00 24.40 ? 182 SER A OG  1 
ATOM   893  N N   . LEU A 1 183 ? 246.618 292.663 362.162 1.00 14.02 ? 183 LEU A N   1 
ATOM   894  C CA  . LEU A 1 183 ? 245.824 293.672 361.485 1.00 10.29 ? 183 LEU A CA  1 
ATOM   895  C C   . LEU A 1 183 ? 245.974 294.983 362.237 1.00 17.24 ? 183 LEU A C   1 
ATOM   896  O O   . LEU A 1 183 ? 245.786 295.027 363.454 1.00 21.55 ? 183 LEU A O   1 
ATOM   897  C CB  . LEU A 1 183 ? 244.358 293.242 361.423 1.00 16.43 ? 183 LEU A CB  1 
ATOM   898  C CG  . LEU A 1 183 ? 243.431 293.919 360.416 1.00 18.71 ? 183 LEU A CG  1 
ATOM   899  C CD1 . LEU A 1 183 ? 243.935 293.752 359.000 1.00 10.27 ? 183 LEU A CD1 1 
ATOM   900  C CD2 . LEU A 1 183 ? 242.036 293.336 360.555 1.00 19.14 ? 183 LEU A CD2 1 
ATOM   901  N N   . PHE A 1 184 ? 246.329 296.041 361.519 1.00 18.22 ? 184 PHE A N   1 
ATOM   902  C CA  . PHE A 1 184 ? 246.420 297.377 362.089 1.00 9.63  ? 184 PHE A CA  1 
ATOM   903  C C   . PHE A 1 184 ? 245.274 298.207 361.533 1.00 11.82 ? 184 PHE A C   1 
ATOM   904  O O   . PHE A 1 184 ? 245.146 298.362 360.315 1.00 16.77 ? 184 PHE A O   1 
ATOM   905  C CB  . PHE A 1 184 ? 247.775 298.018 361.790 1.00 10.93 ? 184 PHE A CB  1 
ATOM   906  C CG  . PHE A 1 184 ? 248.899 297.450 362.605 1.00 12.02 ? 184 PHE A CG  1 
ATOM   907  C CD1 . PHE A 1 184 ? 249.245 298.013 363.820 1.00 15.50 ? 184 PHE A CD1 1 
ATOM   908  C CD2 . PHE A 1 184 ? 249.600 296.343 362.166 1.00 13.31 ? 184 PHE A CD2 1 
ATOM   909  C CE1 . PHE A 1 184 ? 250.273 297.487 364.573 1.00 13.47 ? 184 PHE A CE1 1 
ATOM   910  C CE2 . PHE A 1 184 ? 250.627 295.817 362.916 1.00 7.73  ? 184 PHE A CE2 1 
ATOM   911  C CZ  . PHE A 1 184 ? 250.961 296.388 364.121 1.00 10.81 ? 184 PHE A CZ  1 
ATOM   912  N N   . TYR A 1 185 ? 244.438 298.714 362.428 1.00 13.50 ? 185 TYR A N   1 
ATOM   913  C CA  . TYR A 1 185 ? 243.241 299.457 362.072 1.00 13.60 ? 185 TYR A CA  1 
ATOM   914  C C   . TYR A 1 185 ? 243.379 300.893 362.550 1.00 13.54 ? 185 TYR A C   1 
ATOM   915  O O   . TYR A 1 185 ? 243.753 301.135 363.699 1.00 14.89 ? 185 TYR A O   1 
ATOM   916  C CB  . TYR A 1 185 ? 241.992 298.816 362.686 1.00 10.92 ? 185 TYR A CB  1 
ATOM   917  C CG  . TYR A 1 185 ? 240.768 299.695 362.594 1.00 12.95 ? 185 TYR A CG  1 
ATOM   918  C CD1 . TYR A 1 185 ? 240.014 299.743 361.434 1.00 14.84 ? 185 TYR A CD1 1 
ATOM   919  C CD2 . TYR A 1 185 ? 240.377 300.489 363.661 1.00 13.09 ? 185 TYR A CD2 1 
ATOM   920  C CE1 . TYR A 1 185 ? 238.909 300.551 361.339 1.00 9.89  ? 185 TYR A CE1 1 
ATOM   921  C CE2 . TYR A 1 185 ? 239.274 301.300 363.574 1.00 13.09 ? 185 TYR A CE2 1 
ATOM   922  C CZ  . TYR A 1 185 ? 238.542 301.328 362.411 1.00 11.66 ? 185 TYR A CZ  1 
ATOM   923  O OH  . TYR A 1 185 ? 237.438 302.132 362.319 1.00 23.47 ? 185 TYR A OH  1 
ATOM   924  N N   . THR A 1 186 ? 243.068 301.838 361.673 1.00 10.33 ? 186 THR A N   1 
ATOM   925  C CA  . THR A 1 186 ? 243.071 303.252 362.014 1.00 15.41 ? 186 THR A CA  1 
ATOM   926  C C   . THR A 1 186 ? 241.651 303.684 362.342 1.00 15.94 ? 186 THR A C   1 
ATOM   927  O O   . THR A 1 186 ? 240.730 303.439 361.558 1.00 22.02 ? 186 THR A O   1 
ATOM   928  C CB  . THR A 1 186 ? 243.628 304.093 360.864 1.00 16.83 ? 186 THR A CB  1 
ATOM   929  O OG1 . THR A 1 186 ? 244.911 303.587 360.485 1.00 23.32 ? 186 THR A OG1 1 
ATOM   930  C CG2 . THR A 1 186 ? 243.763 305.546 361.279 1.00 7.62  ? 186 THR A CG2 1 
ATOM   931  N N   . TYR A 1 187 ? 241.480 304.329 363.491 1.00 13.23 ? 187 TYR A N   1 
ATOM   932  C CA  . TYR A 1 187 ? 240.153 304.751 363.913 1.00 15.42 ? 187 TYR A CA  1 
ATOM   933  C C   . TYR A 1 187 ? 239.554 305.721 362.902 1.00 15.19 ? 187 TYR A C   1 
ATOM   934  O O   . TYR A 1 187 ? 240.248 306.574 362.343 1.00 23.66 ? 187 TYR A O   1 
ATOM   935  C CB  . TYR A 1 187 ? 240.214 305.396 365.295 1.00 13.68 ? 187 TYR A CB  1 
ATOM   936  C CG  . TYR A 1 187 ? 238.855 305.613 365.916 1.00 13.68 ? 187 TYR A CG  1 
ATOM   937  C CD1 . TYR A 1 187 ? 238.167 304.565 366.512 1.00 18.49 ? 187 TYR A CD1 1 
ATOM   938  C CD2 . TYR A 1 187 ? 238.256 306.864 365.902 1.00 15.79 ? 187 TYR A CD2 1 
ATOM   939  C CE1 . TYR A 1 187 ? 236.928 304.757 367.080 1.00 15.26 ? 187 TYR A CE1 1 
ATOM   940  C CE2 . TYR A 1 187 ? 237.017 307.067 366.468 1.00 9.52  ? 187 TYR A CE2 1 
ATOM   941  C CZ  . TYR A 1 187 ? 236.356 306.011 367.054 1.00 19.19 ? 187 TYR A CZ  1 
ATOM   942  O OH  . TYR A 1 187 ? 235.122 306.211 367.617 1.00 20.69 ? 187 TYR A OH  1 
ATOM   943  N N   . GLY A 1 188 ? 238.254 305.578 362.663 1.00 20.37 ? 188 GLY A N   1 
ATOM   944  C CA  . GLY A 1 188 ? 237.565 306.358 361.663 1.00 16.47 ? 188 GLY A CA  1 
ATOM   945  C C   . GLY A 1 188 ? 237.551 305.740 360.285 1.00 12.60 ? 188 GLY A C   1 
ATOM   946  O O   . GLY A 1 188 ? 236.789 306.196 359.427 1.00 23.00 ? 188 GLY A O   1 
ATOM   947  N N   . ALA A 1 189 ? 238.366 304.726 360.046 1.00 14.84 ? 189 ALA A N   1 
ATOM   948  C CA  . ALA A 1 189 ? 238.336 303.995 358.797 1.00 14.52 ? 189 ALA A CA  1 
ATOM   949  C C   . ALA A 1 189 ? 237.145 303.045 358.773 1.00 11.74 ? 189 ALA A C   1 
ATOM   950  O O   . ALA A 1 189 ? 236.570 302.729 359.815 1.00 18.91 ? 189 ALA A O   1 
ATOM   951  C CB  . ALA A 1 189 ? 239.635 303.220 358.614 1.00 7.33  ? 189 ALA A CB  1 
ATOM   952  N N   . PRO A 1 190 ? 236.746 302.577 357.592 1.00 17.52 ? 190 PRO A N   1 
ATOM   953  C CA  . PRO A 1 190 ? 235.667 301.601 357.535 1.00 10.73 ? 190 PRO A CA  1 
ATOM   954  C C   . PRO A 1 190 ? 236.044 300.348 358.295 1.00 12.69 ? 190 PRO A C   1 
ATOM   955  O O   . PRO A 1 190 ? 237.233 299.990 358.387 1.00 15.39 ? 190 PRO A O   1 
ATOM   956  C CB  . PRO A 1 190 ? 235.513 301.332 356.031 1.00 6.20  ? 190 PRO A CB  1 
ATOM   957  C CG  . PRO A 1 190 ? 236.763 301.824 355.411 1.00 9.76  ? 190 PRO A CG  1 
ATOM   958  C CD  . PRO A 1 190 ? 237.214 302.958 356.251 1.00 13.38 ? 190 PRO A CD  1 
ATOM   959  N N   . PRO A 1 191 ? 235.063 299.651 358.881 1.00 17.70 ? 191 PRO A N   1 
ATOM   960  C CA  . PRO A 1 191 ? 235.377 298.445 359.660 1.00 11.83 ? 191 PRO A CA  1 
ATOM   961  C C   . PRO A 1 191 ? 236.371 297.524 358.972 1.00 7.27  ? 191 PRO A C   1 
ATOM   962  O O   . PRO A 1 191 ? 236.322 297.348 357.752 1.00 13.30 ? 191 PRO A O   1 
ATOM   963  C CB  . PRO A 1 191 ? 234.006 297.777 359.818 1.00 8.46  ? 191 PRO A CB  1 
ATOM   964  C CG  . PRO A 1 191 ? 233.062 298.906 359.823 1.00 8.38  ? 191 PRO A CG  1 
ATOM   965  C CD  . PRO A 1 191 ? 233.616 299.930 358.873 1.00 7.93  ? 191 PRO A CD  1 
ATOM   966  N N   . ALA A 1 192 ? 237.289 296.948 359.743 1.00 10.16 ? 192 ALA A N   1 
ATOM   967  C CA  . ALA A 1 192 ? 238.296 296.067 359.169 1.00 2.82  ? 192 ALA A CA  1 
ATOM   968  C C   . ALA A 1 192 ? 237.666 294.739 358.766 1.00 11.16 ? 192 ALA A C   1 
ATOM   969  O O   . ALA A 1 192 ? 236.619 294.349 359.276 1.00 16.98 ? 192 ALA A O   1 
ATOM   970  C CB  . ALA A 1 192 ? 239.427 295.836 360.166 1.00 8.52  ? 192 ALA A CB  1 
ATOM   971  N N   . ARG A 1 193 ? 238.303 294.039 357.834 1.00 3.37  ? 193 ARG A N   1 
ATOM   972  C CA  . ARG A 1 193 ? 237.734 292.784 357.363 1.00 8.28  ? 193 ARG A CA  1 
ATOM   973  C C   . ARG A 1 193 ? 238.820 291.856 356.847 1.00 7.92  ? 193 ARG A C   1 
ATOM   974  O O   . ARG A 1 193 ? 239.670 292.268 356.056 1.00 15.49 ? 193 ARG A O   1 
ATOM   975  C CB  . ARG A 1 193 ? 236.697 293.031 356.264 1.00 13.73 ? 193 ARG A CB  1 
ATOM   976  C CG  . ARG A 1 193 ? 236.194 291.757 355.609 1.00 12.31 ? 193 ARG A CG  1 
ATOM   977  C CD  . ARG A 1 193 ? 235.108 292.041 354.609 1.00 13.52 ? 193 ARG A CD  1 
ATOM   978  N NE  . ARG A 1 193 ? 233.866 292.409 355.273 1.00 20.38 ? 193 ARG A NE  1 
ATOM   979  C CZ  . ARG A 1 193 ? 232.747 292.733 354.647 1.00 17.43 ? 193 ARG A CZ  1 
ATOM   980  N NH1 . ARG A 1 193 ? 232.680 292.776 353.328 1.00 16.06 ? 193 ARG A NH1 1 
ATOM   981  N NH2 . ARG A 1 193 ? 231.669 293.025 355.363 1.00 13.49 ? 193 ARG A NH2 1 
ATOM   982  N N   . ILE A 1 194 ? 238.762 290.595 357.275 1.00 15.65 ? 194 ILE A N   1 
ATOM   983  C CA  . ILE A 1 194 ? 239.622 289.547 356.737 1.00 10.53 ? 194 ILE A CA  1 
ATOM   984  C C   . ILE A 1 194 ? 238.776 288.315 356.461 1.00 11.93 ? 194 ILE A C   1 
ATOM   985  O O   . ILE A 1 194 ? 237.650 288.187 356.946 1.00 23.82 ? 194 ILE A O   1 
ATOM   986  C CB  . ILE A 1 194 ? 240.797 289.192 357.680 1.00 12.37 ? 194 ILE A CB  1 
ATOM   987  C CG1 . ILE A 1 194 ? 240.281 288.696 359.034 1.00 16.96 ? 194 ILE A CG1 1 
ATOM   988  C CG2 . ILE A 1 194 ? 241.723 290.385 357.861 1.00 16.21 ? 194 ILE A CG2 1 
ATOM   989  C CD1 . ILE A 1 194 ? 240.158 287.185 359.130 1.00 16.09 ? 194 ILE A CD1 1 
ATOM   990  N N   . SER A 1 195 ? 239.324 287.409 355.662 1.00 15.02 ? 195 SER A N   1 
ATOM   991  C CA  . SER A 1 195 ? 238.709 286.121 355.394 1.00 16.79 ? 195 SER A CA  1 
ATOM   992  C C   . SER A 1 195 ? 239.699 285.008 355.708 1.00 13.71 ? 195 SER A C   1 
ATOM   993  O O   . SER A 1 195 ? 240.912 285.186 355.572 1.00 15.38 ? 195 SER A O   1 
ATOM   994  C CB  . SER A 1 195 ? 238.246 286.021 353.939 1.00 13.31 ? 195 SER A CB  1 
ATOM   995  O OG  . SER A 1 195 ? 239.328 286.158 353.039 1.00 23.93 ? 195 SER A OG  1 
ATOM   996  N N   . VAL A 1 196 ? 239.175 283.873 356.158 1.00 15.27 ? 196 VAL A N   1 
ATOM   997  C CA  . VAL A 1 196 ? 239.970 282.671 356.397 1.00 17.42 ? 196 VAL A CA  1 
ATOM   998  C C   . VAL A 1 196 ? 239.251 281.491 355.756 1.00 14.53 ? 196 VAL A C   1 
ATOM   999  O O   . VAL A 1 196 ? 238.016 281.500 355.660 1.00 19.86 ? 196 VAL A O   1 
ATOM   1000 C CB  . VAL A 1 196 ? 240.200 282.427 357.897 1.00 18.91 ? 196 VAL A CB  1 
ATOM   1001 C CG1 . VAL A 1 196 ? 241.125 283.484 358.471 1.00 23.13 ? 196 VAL A CG1 1 
ATOM   1002 C CG2 . VAL A 1 196 ? 238.878 282.401 358.644 1.00 17.18 ? 196 VAL A CG2 1 
ATOM   1003 N N   . PRO A 1 197 ? 239.969 280.461 355.312 1.00 19.86 ? 197 PRO A N   1 
ATOM   1004 C CA  . PRO A 1 197 ? 239.301 279.287 354.739 1.00 11.64 ? 197 PRO A CA  1 
ATOM   1005 C C   . PRO A 1 197 ? 238.836 278.315 355.814 1.00 10.53 ? 197 PRO A C   1 
ATOM   1006 O O   . PRO A 1 197 ? 238.926 278.621 357.004 1.00 14.25 ? 197 PRO A O   1 
ATOM   1007 C CB  . PRO A 1 197 ? 240.389 278.682 353.847 1.00 17.71 ? 197 PRO A CB  1 
ATOM   1008 C CG  . PRO A 1 197 ? 241.661 279.030 354.542 1.00 10.06 ? 197 PRO A CG  1 
ATOM   1009 C CD  . PRO A 1 197 ? 241.436 280.338 355.258 1.00 15.60 ? 197 PRO A CD  1 
ATOM   1010 N N   . TYR A 1 198 ? 238.325 277.153 355.419 1.00 13.81 ? 198 TYR A N   1 
ATOM   1011 C CA  . TYR A 1 198 ? 238.006 276.117 356.394 1.00 15.52 ? 198 TYR A CA  1 
ATOM   1012 C C   . TYR A 1 198 ? 239.299 275.595 357.013 1.00 13.47 ? 198 TYR A C   1 
ATOM   1013 O O   . TYR A 1 198 ? 240.160 275.061 356.309 1.00 17.59 ? 198 TYR A O   1 
ATOM   1014 C CB  . TYR A 1 198 ? 237.218 274.982 355.739 1.00 10.55 ? 198 TYR A CB  1 
ATOM   1015 C CG  . TYR A 1 198 ? 237.099 273.771 356.632 1.00 11.94 ? 198 TYR A CG  1 
ATOM   1016 C CD1 . TYR A 1 198 ? 236.246 273.772 357.726 1.00 16.42 ? 198 TYR A CD1 1 
ATOM   1017 C CD2 . TYR A 1 198 ? 237.863 272.637 356.400 1.00 11.78 ? 198 TYR A CD2 1 
ATOM   1018 C CE1 . TYR A 1 198 ? 236.151 272.674 358.556 1.00 14.85 ? 198 TYR A CE1 1 
ATOM   1019 C CE2 . TYR A 1 198 ? 237.773 271.539 357.221 1.00 8.32  ? 198 TYR A CE2 1 
ATOM   1020 C CZ  . TYR A 1 198 ? 236.915 271.562 358.296 1.00 8.63  ? 198 TYR A CZ  1 
ATOM   1021 O OH  . TYR A 1 198 ? 236.833 270.469 359.113 1.00 17.88 ? 198 TYR A OH  1 
ATOM   1022 N N   . VAL A 1 199 ? 239.436 275.750 358.328 1.00 10.58 ? 199 VAL A N   1 
ATOM   1023 C CA  . VAL A 1 199 ? 240.689 275.480 359.022 1.00 12.77 ? 199 VAL A CA  1 
ATOM   1024 C C   . VAL A 1 199 ? 240.569 274.319 359.999 1.00 18.17 ? 199 VAL A C   1 
ATOM   1025 O O   . VAL A 1 199 ? 241.442 274.148 360.854 1.00 22.11 ? 199 VAL A O   1 
ATOM   1026 C CB  . VAL A 1 199 ? 241.207 276.733 359.745 1.00 9.11  ? 199 VAL A CB  1 
ATOM   1027 C CG1 . VAL A 1 199 ? 241.696 277.762 358.742 1.00 13.64 ? 199 VAL A CG1 1 
ATOM   1028 C CG2 . VAL A 1 199 ? 240.130 277.314 360.647 1.00 18.51 ? 199 VAL A CG2 1 
ATOM   1029 N N   . GLY A 1 200 ? 239.512 273.517 359.902 1.00 12.22 ? 200 GLY A N   1 
ATOM   1030 C CA  . GLY A 1 200 ? 239.337 272.426 360.842 1.00 12.37 ? 200 GLY A CA  1 
ATOM   1031 C C   . GLY A 1 200 ? 240.335 271.306 360.603 1.00 12.63 ? 200 GLY A C   1 
ATOM   1032 O O   . GLY A 1 200 ? 240.660 270.962 359.466 1.00 16.47 ? 200 GLY A O   1 
ATOM   1033 N N   . ILE A 1 201 ? 240.831 270.730 361.701 1.00 14.42 ? 201 ILE A N   1 
ATOM   1034 C CA  . ILE A 1 201 ? 241.726 269.585 361.594 1.00 19.41 ? 201 ILE A CA  1 
ATOM   1035 C C   . ILE A 1 201 ? 240.977 268.325 361.183 1.00 14.83 ? 201 ILE A C   1 
ATOM   1036 O O   . ILE A 1 201 ? 241.581 267.414 360.608 1.00 19.13 ? 201 ILE A O   1 
ATOM   1037 C CB  . ILE A 1 201 ? 242.493 269.357 362.911 1.00 20.17 ? 201 ILE A CB  1 
ATOM   1038 C CG1 . ILE A 1 201 ? 241.526 269.124 364.074 1.00 13.98 ? 201 ILE A CG1 1 
ATOM   1039 C CG2 . ILE A 1 201 ? 243.414 270.539 363.192 1.00 10.71 ? 201 ILE A CG2 1 
ATOM   1040 C CD1 . ILE A 1 201 ? 242.209 268.811 365.382 1.00 15.42 ? 201 ILE A CD1 1 
ATOM   1041 N N   . ALA A 1 202 ? 239.679 268.244 361.461 1.00 17.48 ? 202 ALA A N   1 
ATOM   1042 C CA  . ALA A 1 202 ? 238.848 267.168 360.951 1.00 9.82  ? 202 ALA A CA  1 
ATOM   1043 C C   . ALA A 1 202 ? 238.284 267.563 359.589 1.00 11.49 ? 202 ALA A C   1 
ATOM   1044 O O   . ALA A 1 202 ? 238.497 268.671 359.099 1.00 15.20 ? 202 ALA A O   1 
ATOM   1045 C CB  . ALA A 1 202 ? 237.732 266.836 361.939 1.00 11.26 ? 202 ALA A CB  1 
ATOM   1046 N N   . ASN A 1 203 ? 237.550 266.645 358.963 1.00 15.62 ? 203 ASN A N   1 
ATOM   1047 C CA  . ASN A 1 203 ? 236.955 266.924 357.663 1.00 14.86 ? 203 ASN A CA  1 
ATOM   1048 C C   . ASN A 1 203 ? 235.770 267.874 357.745 1.00 10.73 ? 203 ASN A C   1 
ATOM   1049 O O   . ASN A 1 203 ? 235.332 268.381 356.710 1.00 23.34 ? 203 ASN A O   1 
ATOM   1050 C CB  . ASN A 1 203 ? 236.515 265.624 356.993 1.00 8.14  ? 203 ASN A CB  1 
ATOM   1051 C CG  . ASN A 1 203 ? 237.666 264.682 356.746 1.00 11.68 ? 203 ASN A CG  1 
ATOM   1052 O OD1 . ASN A 1 203 ? 237.880 263.738 357.501 1.00 17.70 ? 203 ASN A OD1 1 
ATOM   1053 N ND2 . ASN A 1 203 ? 238.419 264.934 355.686 1.00 14.62 ? 203 ASN A ND2 1 
ATOM   1054 N N   . ALA A 1 204 ? 235.241 268.121 358.937 1.00 7.69  ? 204 ALA A N   1 
ATOM   1055 C CA  . ALA A 1 204 ? 234.196 269.112 359.122 1.00 9.38  ? 204 ALA A CA  1 
ATOM   1056 C C   . ALA A 1 204 ? 234.267 269.606 360.555 1.00 14.47 ? 204 ALA A C   1 
ATOM   1057 O O   . ALA A 1 204 ? 234.863 268.962 361.421 1.00 17.59 ? 204 ALA A O   1 
ATOM   1058 C CB  . ALA A 1 204 ? 232.808 268.538 358.813 1.00 10.68 ? 204 ALA A CB  1 
ATOM   1059 N N   . TYR A 1 205 ? 233.666 270.766 360.788 1.00 6.83  ? 205 TYR A N   1 
ATOM   1060 C CA  . TYR A 1 205 ? 233.480 271.244 362.146 1.00 10.77 ? 205 TYR A CA  1 
ATOM   1061 C C   . TYR A 1 205 ? 232.426 270.403 362.852 1.00 19.00 ? 205 TYR A C   1 
ATOM   1062 O O   . TYR A 1 205 ? 231.467 269.931 362.240 1.00 23.68 ? 205 TYR A O   1 
ATOM   1063 C CB  . TYR A 1 205 ? 233.047 272.709 362.149 1.00 12.04 ? 205 TYR A CB  1 
ATOM   1064 C CG  . TYR A 1 205 ? 234.067 273.673 361.592 1.00 17.20 ? 205 TYR A CG  1 
ATOM   1065 C CD1 . TYR A 1 205 ? 235.398 273.608 361.979 1.00 14.16 ? 205 TYR A CD1 1 
ATOM   1066 C CD2 . TYR A 1 205 ? 233.695 274.654 360.679 1.00 14.09 ? 205 TYR A CD2 1 
ATOM   1067 C CE1 . TYR A 1 205 ? 236.328 274.488 361.475 1.00 9.39  ? 205 TYR A CE1 1 
ATOM   1068 C CE2 . TYR A 1 205 ? 234.620 275.537 360.168 1.00 10.23 ? 205 TYR A CE2 1 
ATOM   1069 C CZ  . TYR A 1 205 ? 235.937 275.448 360.571 1.00 16.27 ? 205 TYR A CZ  1 
ATOM   1070 O OH  . TYR A 1 205 ? 236.867 276.321 360.067 1.00 24.76 ? 205 TYR A OH  1 
ATOM   1071 N N   . SER A 1 206 ? 232.608 270.219 364.153 1.00 14.67 ? 206 SER A N   1 
ATOM   1072 C CA  . SER A 1 206 ? 231.642 269.519 364.988 1.00 9.92  ? 206 SER A CA  1 
ATOM   1073 C C   . SER A 1 206 ? 230.929 270.534 365.867 1.00 13.65 ? 206 SER A C   1 
ATOM   1074 O O   . SER A 1 206 ? 231.552 271.157 366.731 1.00 16.97 ? 206 SER A O   1 
ATOM   1075 C CB  . SER A 1 206 ? 232.318 268.452 365.847 1.00 11.69 ? 206 SER A CB  1 
ATOM   1076 O OG  . SER A 1 206 ? 232.767 267.373 365.054 1.00 25.15 ? 206 SER A OG  1 
ATOM   1077 N N   . HIS A 1 207 ? 229.627 270.700 365.641 1.00 12.19 ? 207 HIS A N   1 
ATOM   1078 C CA  . HIS A 1 207 ? 228.818 271.504 366.546 1.00 9.85  ? 207 HIS A CA  1 
ATOM   1079 C C   . HIS A 1 207 ? 228.527 270.753 367.835 1.00 8.24  ? 207 HIS A C   1 
ATOM   1080 O O   . HIS A 1 207 ? 228.327 271.375 368.881 1.00 16.31 ? 207 HIS A O   1 
ATOM   1081 C CB  . HIS A 1 207 ? 227.518 271.914 365.857 1.00 15.29 ? 207 HIS A CB  1 
ATOM   1082 C CG  . HIS A 1 207 ? 227.724 272.611 364.550 1.00 9.97  ? 207 HIS A CG  1 
ATOM   1083 N ND1 . HIS A 1 207 ? 226.768 272.634 363.560 1.00 16.94 ? 207 HIS A ND1 1 
ATOM   1084 C CD2 . HIS A 1 207 ? 228.779 273.310 364.070 1.00 13.63 ? 207 HIS A CD2 1 
ATOM   1085 C CE1 . HIS A 1 207 ? 227.224 273.317 362.526 1.00 17.50 ? 207 HIS A CE1 1 
ATOM   1086 N NE2 . HIS A 1 207 ? 228.442 273.738 362.810 1.00 13.90 ? 207 HIS A NE2 1 
ATOM   1087 N N   . PHE A 1 208 ? 228.511 269.426 367.773 1.00 18.06 ? 208 PHE A N   1 
ATOM   1088 C CA  . PHE A 1 208 ? 228.276 268.568 368.922 1.00 8.60  ? 208 PHE A CA  1 
ATOM   1089 C C   . PHE A 1 208 ? 229.301 267.446 368.905 1.00 13.38 ? 208 PHE A C   1 
ATOM   1090 O O   . PHE A 1 208 ? 229.572 266.860 367.855 1.00 17.25 ? 208 PHE A O   1 
ATOM   1091 C CB  . PHE A 1 208 ? 226.846 267.995 368.904 1.00 8.03  ? 208 PHE A CB  1 
ATOM   1092 C CG  . PHE A 1 208 ? 225.774 269.046 368.960 1.00 12.59 ? 208 PHE A CG  1 
ATOM   1093 C CD1 . PHE A 1 208 ? 225.363 269.702 367.813 1.00 7.35  ? 208 PHE A CD1 1 
ATOM   1094 C CD2 . PHE A 1 208 ? 225.187 269.385 370.160 1.00 10.26 ? 208 PHE A CD2 1 
ATOM   1095 C CE1 . PHE A 1 208 ? 224.389 270.675 367.869 1.00 6.99  ? 208 PHE A CE1 1 
ATOM   1096 C CE2 . PHE A 1 208 ? 224.212 270.356 370.218 1.00 12.49 ? 208 PHE A CE2 1 
ATOM   1097 C CZ  . PHE A 1 208 ? 223.812 270.999 369.072 1.00 5.91  ? 208 PHE A CZ  1 
ATOM   1098 N N   . TYR A 1 209 ? 229.886 267.166 370.066 1.00 17.56 ? 209 TYR A N   1 
ATOM   1099 C CA  . TYR A 1 209 ? 230.844 266.076 370.219 1.00 16.08 ? 209 TYR A CA  1 
ATOM   1100 C C   . TYR A 1 209 ? 230.449 265.268 371.445 1.00 17.06 ? 209 TYR A C   1 
ATOM   1101 O O   . TYR A 1 209 ? 230.562 265.750 372.575 1.00 17.62 ? 209 TYR A O   1 
ATOM   1102 C CB  . TYR A 1 209 ? 232.275 266.599 370.344 1.00 16.27 ? 209 TYR A CB  1 
ATOM   1103 C CG  . TYR A 1 209 ? 233.294 265.500 370.524 1.00 19.09 ? 209 TYR A CG  1 
ATOM   1104 C CD1 . TYR A 1 209 ? 233.707 264.728 369.448 1.00 15.68 ? 209 TYR A CD1 1 
ATOM   1105 C CD2 . TYR A 1 209 ? 233.836 265.228 371.770 1.00 18.11 ? 209 TYR A CD2 1 
ATOM   1106 C CE1 . TYR A 1 209 ? 234.633 263.723 369.609 1.00 18.29 ? 209 TYR A CE1 1 
ATOM   1107 C CE2 . TYR A 1 209 ? 234.759 264.227 371.939 1.00 15.79 ? 209 TYR A CE2 1 
ATOM   1108 C CZ  . TYR A 1 209 ? 235.153 263.475 370.858 1.00 16.37 ? 209 TYR A CZ  1 
ATOM   1109 O OH  . TYR A 1 209 ? 236.074 262.475 371.027 1.00 22.06 ? 209 TYR A OH  1 
ATOM   1110 N N   . ASP A 1 210 ? 229.992 264.038 371.219 1.00 18.44 ? 210 ASP A N   1 
ATOM   1111 C CA  . ASP A 1 210 ? 229.509 263.176 372.293 1.00 17.47 ? 210 ASP A CA  1 
ATOM   1112 C C   . ASP A 1 210 ? 230.655 262.273 372.742 1.00 21.88 ? 210 ASP A C   1 
ATOM   1113 O O   . ASP A 1 210 ? 230.722 261.084 372.424 1.00 27.42 ? 210 ASP A O   1 
ATOM   1114 C CB  . ASP A 1 210 ? 228.303 262.374 371.825 1.00 15.13 ? 210 ASP A CB  1 
ATOM   1115 C CG  . ASP A 1 210 ? 227.643 261.608 372.945 1.00 19.80 ? 210 ASP A CG  1 
ATOM   1116 O OD1 . ASP A 1 210 ? 227.897 261.939 374.118 1.00 27.86 ? 210 ASP A OD1 1 
ATOM   1117 O OD2 . ASP A 1 210 ? 226.873 260.672 372.656 1.00 19.55 ? 210 ASP A OD2 1 
ATOM   1118 N N   . GLY A 1 211 ? 231.571 262.854 373.504 1.00 19.57 ? 211 GLY A N   1 
ATOM   1119 C CA  . GLY A 1 211 ? 232.731 262.106 373.940 1.00 16.63 ? 211 GLY A CA  1 
ATOM   1120 C C   . GLY A 1 211 ? 233.631 262.946 374.814 1.00 16.41 ? 211 GLY A C   1 
ATOM   1121 O O   . GLY A 1 211 ? 233.281 264.051 375.229 1.00 21.02 ? 211 GLY A O   1 
ATOM   1122 N N   . PHE A 1 212 ? 234.808 262.393 375.085 1.00 20.70 ? 212 PHE A N   1 
ATOM   1123 C CA  . PHE A 1 212 ? 235.802 263.005 375.949 1.00 20.81 ? 212 PHE A CA  1 
ATOM   1124 C C   . PHE A 1 212 ? 237.123 263.129 375.205 1.00 22.15 ? 212 PHE A C   1 
ATOM   1125 O O   . PHE A 1 212 ? 237.382 262.418 374.232 1.00 19.50 ? 212 PHE A O   1 
ATOM   1126 C CB  . PHE A 1 212 ? 236.004 262.186 377.228 1.00 19.00 ? 212 PHE A CB  1 
ATOM   1127 C CG  . PHE A 1 212 ? 234.799 262.141 378.116 1.00 21.75 ? 212 PHE A CG  1 
ATOM   1128 C CD1 . PHE A 1 212 ? 233.757 261.270 377.851 1.00 19.51 ? 212 PHE A CD1 1 
ATOM   1129 C CD2 . PHE A 1 212 ? 234.709 262.963 379.223 1.00 22.81 ? 212 PHE A CD2 1 
ATOM   1130 C CE1 . PHE A 1 212 ? 232.652 261.228 378.669 1.00 17.58 ? 212 PHE A CE1 1 
ATOM   1131 C CE2 . PHE A 1 212 ? 233.605 262.922 380.044 1.00 22.12 ? 212 PHE A CE2 1 
ATOM   1132 C CZ  . PHE A 1 212 ? 232.577 262.056 379.767 1.00 19.12 ? 212 PHE A CZ  1 
ATOM   1133 N N   . ALA A 1 213 ? 237.953 264.064 375.664 1.00 34.55 ? 213 ALA A N   1 
ATOM   1134 C CA  . ALA A 1 213 ? 239.305 264.184 375.130 1.00 28.77 ? 213 ALA A CA  1 
ATOM   1135 C C   . ALA A 1 213 ? 240.215 263.096 375.685 1.00 28.89 ? 213 ALA A C   1 
ATOM   1136 O O   . ALA A 1 213 ? 241.081 262.584 374.969 1.00 31.11 ? 213 ALA A O   1 
ATOM   1137 C CB  . ALA A 1 213 ? 239.873 265.567 375.446 1.00 27.75 ? 213 ALA A CB  1 
ATOM   1138 N N   . LYS A 1 214 ? 240.036 262.739 376.954 1.00 34.84 ? 214 LYS A N   1 
ATOM   1139 C CA  . LYS A 1 214 ? 240.770 261.660 377.597 1.00 36.94 ? 214 LYS A CA  1 
ATOM   1140 C C   . LYS A 1 214 ? 239.794 260.596 378.067 1.00 32.87 ? 214 LYS A C   1 
ATOM   1141 O O   . LYS A 1 214 ? 238.734 260.914 378.612 1.00 40.04 ? 214 LYS A O   1 
ATOM   1142 C CB  . LYS A 1 214 ? 241.562 262.140 378.818 1.00 38.85 ? 214 LYS A CB  1 
ATOM   1143 C CG  . LYS A 1 214 ? 242.336 263.425 378.661 1.00 40.02 ? 214 LYS A CG  1 
ATOM   1144 C CD  . LYS A 1 214 ? 242.725 263.944 380.035 1.00 42.01 ? 214 LYS A CD  1 
ATOM   1145 C CE  . LYS A 1 214 ? 243.706 265.094 379.964 1.00 40.99 ? 214 LYS A CE  1 
ATOM   1146 N NZ  . LYS A 1 214 ? 244.073 265.576 381.320 1.00 43.60 ? 214 LYS A NZ  1 
ATOM   1147 N N   . VAL A 1 215 ? 240.157 259.336 377.870 1.00 33.72 ? 215 VAL A N   1 
ATOM   1148 C CA  . VAL A 1 215 ? 239.476 258.217 378.512 1.00 38.52 ? 215 VAL A CA  1 
ATOM   1149 C C   . VAL A 1 215 ? 240.205 257.932 379.822 1.00 37.21 ? 215 VAL A C   1 
ATOM   1150 O O   . VAL A 1 215 ? 241.400 257.610 379.787 1.00 34.96 ? 215 VAL A O   1 
ATOM   1151 C CB  . VAL A 1 215 ? 239.457 256.972 377.620 1.00 37.36 ? 215 VAL A CB  1 
ATOM   1152 C CG1 . VAL A 1 215 ? 238.733 255.833 378.319 1.00 31.46 ? 215 VAL A CG1 1 
ATOM   1153 C CG2 . VAL A 1 215 ? 238.810 257.289 376.292 1.00 35.21 ? 215 VAL A CG2 1 
ATOM   1154 N N   . PRO A 1 216 ? 239.549 258.050 380.975 1.00 39.04 ? 216 PRO A N   1 
ATOM   1155 C CA  . PRO A 1 216 ? 240.218 257.686 382.229 1.00 39.03 ? 216 PRO A CA  1 
ATOM   1156 C C   . PRO A 1 216 ? 240.479 256.187 382.277 1.00 37.24 ? 216 PRO A C   1 
ATOM   1157 O O   . PRO A 1 216 ? 239.610 255.379 381.944 1.00 39.27 ? 216 PRO A O   1 
ATOM   1158 C CB  . PRO A 1 216 ? 239.226 258.133 383.307 1.00 40.06 ? 216 PRO A CB  1 
ATOM   1159 C CG  . PRO A 1 216 ? 237.906 258.106 382.632 1.00 37.03 ? 216 PRO A CG  1 
ATOM   1160 C CD  . PRO A 1 216 ? 238.146 258.441 381.194 1.00 35.90 ? 216 PRO A CD  1 
ATOM   1161 N N   . LEU A 1 217 ? 241.686 255.822 382.683 1.00 43.57 ? 217 LEU A N   1 
ATOM   1162 C CA  . LEU A 1 217 ? 242.118 254.435 382.701 1.00 44.00 ? 217 LEU A CA  1 
ATOM   1163 C C   . LEU A 1 217 ? 242.185 253.918 384.129 1.00 43.19 ? 217 LEU A C   1 
ATOM   1164 O O   . LEU A 1 217 ? 242.483 254.663 385.065 1.00 45.88 ? 217 LEU A O   1 
ATOM   1165 C CB  . LEU A 1 217 ? 243.484 254.286 382.029 1.00 42.52 ? 217 LEU A CB  1 
ATOM   1166 C CG  . LEU A 1 217 ? 243.515 254.620 380.539 1.00 42.08 ? 217 LEU A CG  1 
ATOM   1167 C CD1 . LEU A 1 217 ? 244.936 254.611 380.018 1.00 42.02 ? 217 LEU A CD1 1 
ATOM   1168 C CD2 . LEU A 1 217 ? 242.647 253.649 379.751 1.00 42.08 ? 217 LEU A CD2 1 
ATOM   1169 N N   . ALA A 1 218 ? 241.890 252.632 384.290 1.00 48.22 ? 218 ALA A N   1 
ATOM   1170 C CA  . ALA A 1 218 ? 242.061 251.992 385.585 1.00 47.74 ? 218 ALA A CA  1 
ATOM   1171 C C   . ALA A 1 218 ? 243.507 252.132 386.038 1.00 49.86 ? 218 ALA A C   1 
ATOM   1172 O O   . ALA A 1 218 ? 244.442 251.914 385.263 1.00 48.54 ? 218 ALA A O   1 
ATOM   1173 C CB  . ALA A 1 218 ? 241.668 250.518 385.508 1.00 44.67 ? 218 ALA A CB  1 
ATOM   1174 N N   . GLY A 1 219 ? 243.687 252.505 387.301 1.00 53.38 ? 219 GLY A N   1 
ATOM   1175 C CA  . GLY A 1 219 ? 245.008 252.799 387.816 1.00 53.30 ? 219 GLY A CA  1 
ATOM   1176 C C   . GLY A 1 219 ? 245.212 254.287 388.007 1.00 55.46 ? 219 GLY A C   1 
ATOM   1177 O O   . GLY A 1 219 ? 245.927 254.711 388.919 1.00 56.96 ? 219 GLY A O   1 
ATOM   1178 N N   . GLN A 1 220 ? 244.591 255.088 387.145 1.00 57.61 ? 220 GLN A N   1 
ATOM   1179 C CA  . GLN A 1 220 ? 244.647 256.536 387.289 1.00 57.45 ? 220 GLN A CA  1 
ATOM   1180 C C   . GLN A 1 220 ? 243.877 256.978 388.526 1.00 58.28 ? 220 GLN A C   1 
ATOM   1181 O O   . GLN A 1 220 ? 242.881 256.361 388.913 1.00 57.70 ? 220 GLN A O   1 
ATOM   1182 C CB  . GLN A 1 220 ? 244.075 257.220 386.048 1.00 55.05 ? 220 GLN A CB  1 
ATOM   1183 C CG  . GLN A 1 220 ? 244.838 256.933 384.772 1.00 54.88 ? 220 GLN A CG  1 
ATOM   1184 C CD  . GLN A 1 220 ? 244.425 257.841 383.632 1.00 55.75 ? 220 GLN A CD  1 
ATOM   1185 O OE1 . GLN A 1 220 ? 243.412 257.610 382.975 1.00 55.24 ? 220 GLN A OE1 1 
ATOM   1186 N NE2 . GLN A 1 220 ? 245.210 258.883 383.394 1.00 56.09 ? 220 GLN A NE2 1 
ATOM   1187 N N   . ALA A 1 221 ? 244.342 258.061 389.145 1.00 63.73 ? 221 ALA A N   1 
ATOM   1188 C CA  . ALA A 1 221 ? 243.702 258.584 390.341 1.00 62.78 ? 221 ALA A CA  1 
ATOM   1189 C C   . ALA A 1 221 ? 242.361 259.228 389.987 1.00 64.12 ? 221 ALA A C   1 
ATOM   1190 O O   . ALA A 1 221 ? 241.921 259.232 388.833 1.00 63.39 ? 221 ALA A O   1 
ATOM   1191 C CB  . ALA A 1 221 ? 244.623 259.584 391.035 1.00 60.76 ? 221 ALA A CB  1 
ATOM   1192 N N   . SER A 1 222 ? 241.702 259.776 391.002 1.00 65.26 ? 222 SER A N   1 
ATOM   1193 C CA  . SER A 1 222 ? 240.394 260.400 390.831 1.00 64.68 ? 222 SER A CA  1 
ATOM   1194 C C   . SER A 1 222 ? 240.465 261.573 389.859 1.00 63.61 ? 222 SER A C   1 
ATOM   1195 O O   . SER A 1 222 ? 239.576 261.758 389.027 1.00 62.78 ? 222 SER A O   1 
ATOM   1196 C CB  . SER A 1 222 ? 239.850 260.869 392.182 1.00 64.58 ? 222 SER A CB  1 
ATOM   1197 O OG  . SER A 1 222 ? 238.558 261.435 392.049 1.00 65.31 ? 222 SER A OG  1 
ATOM   1198 N N   . GLY A 1 225 ? 242.444 260.881 383.970 1.00 43.45 ? 225 GLY A N   1 
ATOM   1199 C CA  . GLY A 1 225 ? 241.829 261.175 382.689 1.00 46.55 ? 225 GLY A CA  1 
ATOM   1200 C C   . GLY A 1 225 ? 240.522 261.926 382.834 1.00 48.27 ? 225 GLY A C   1 
ATOM   1201 O O   . GLY A 1 225 ? 239.551 261.648 382.130 1.00 48.57 ? 225 GLY A O   1 
ATOM   1202 N N   . ASP A 1 226 ? 240.506 262.895 383.750 1.00 50.61 ? 226 ASP A N   1 
ATOM   1203 C CA  . ASP A 1 226 ? 239.302 263.667 384.056 1.00 47.10 ? 226 ASP A CA  1 
ATOM   1204 C C   . ASP A 1 226 ? 239.247 264.892 383.146 1.00 47.37 ? 226 ASP A C   1 
ATOM   1205 O O   . ASP A 1 226 ? 239.660 265.997 383.501 1.00 49.06 ? 226 ASP A O   1 
ATOM   1206 C CB  . ASP A 1 226 ? 239.287 264.060 385.528 1.00 47.39 ? 226 ASP A CB  1 
ATOM   1207 C CG  . ASP A 1 226 ? 237.961 264.650 385.962 1.00 50.29 ? 226 ASP A CG  1 
ATOM   1208 O OD1 . ASP A 1 226 ? 237.222 265.165 385.099 1.00 49.39 ? 226 ASP A OD1 1 
ATOM   1209 O OD2 . ASP A 1 226 ? 237.660 264.600 387.173 1.00 51.85 ? 226 ASP A OD2 1 
ATOM   1210 N N   . SER A 1 227 ? 238.722 264.681 381.946 1.00 40.13 ? 227 SER A N   1 
ATOM   1211 C CA  . SER A 1 227 ? 238.423 265.759 381.017 1.00 36.73 ? 227 SER A CA  1 
ATOM   1212 C C   . SER A 1 227 ? 236.927 266.048 381.029 1.00 33.98 ? 227 SER A C   1 
ATOM   1213 O O   . SER A 1 227 ? 236.113 265.213 381.429 1.00 39.18 ? 227 SER A O   1 
ATOM   1214 C CB  . SER A 1 227 ? 238.887 265.405 379.602 1.00 39.57 ? 227 SER A CB  1 
ATOM   1215 O OG  . SER A 1 227 ? 238.220 264.256 379.113 1.00 39.16 ? 227 SER A OG  1 
ATOM   1216 N N   . LEU A 1 228 ? 236.570 267.253 380.598 1.00 25.56 ? 228 LEU A N   1 
ATOM   1217 C CA  . LEU A 1 228 ? 235.171 267.649 380.593 1.00 29.43 ? 228 LEU A CA  1 
ATOM   1218 C C   . LEU A 1 228 ? 234.417 266.975 379.452 1.00 27.89 ? 228 LEU A C   1 
ATOM   1219 O O   . LEU A 1 228 ? 234.976 266.675 378.396 1.00 33.13 ? 228 LEU A O   1 
ATOM   1220 C CB  . LEU A 1 228 ? 235.042 269.167 380.478 1.00 28.51 ? 228 LEU A CB  1 
ATOM   1221 C CG  . LEU A 1 228 ? 235.513 269.979 381.687 1.00 29.48 ? 228 LEU A CG  1 
ATOM   1222 C CD1 . LEU A 1 228 ? 235.299 271.459 381.437 1.00 27.92 ? 228 LEU A CD1 1 
ATOM   1223 C CD2 . LEU A 1 228 ? 234.802 269.545 382.956 1.00 25.38 ? 228 LEU A CD2 1 
ATOM   1224 N N   . TYR A 1 229 ? 233.129 266.743 379.681 1.00 21.66 ? 229 TYR A N   1 
ATOM   1225 C CA  . TYR A 1 229 ? 232.290 266.091 378.687 1.00 22.44 ? 229 TYR A CA  1 
ATOM   1226 C C   . TYR A 1 229 ? 232.079 267.007 377.488 1.00 24.32 ? 229 TYR A C   1 
ATOM   1227 O O   . TYR A 1 229 ? 231.694 268.169 377.638 1.00 27.16 ? 229 TYR A O   1 
ATOM   1228 C CB  . TYR A 1 229 ? 230.950 265.709 379.312 1.00 21.27 ? 229 TYR A CB  1 
ATOM   1229 C CG  . TYR A 1 229 ? 229.954 265.103 378.349 1.00 22.45 ? 229 TYR A CG  1 
ATOM   1230 C CD1 . TYR A 1 229 ? 230.245 263.934 377.661 1.00 19.22 ? 229 TYR A CD1 1 
ATOM   1231 C CD2 . TYR A 1 229 ? 228.714 265.693 378.143 1.00 20.81 ? 229 TYR A CD2 1 
ATOM   1232 C CE1 . TYR A 1 229 ? 229.337 263.376 376.787 1.00 21.51 ? 229 TYR A CE1 1 
ATOM   1233 C CE2 . TYR A 1 229 ? 227.798 265.141 377.274 1.00 23.42 ? 229 TYR A CE2 1 
ATOM   1234 C CZ  . TYR A 1 229 ? 228.113 263.982 376.597 1.00 24.63 ? 229 TYR A CZ  1 
ATOM   1235 O OH  . TYR A 1 229 ? 227.203 263.428 375.729 1.00 25.82 ? 229 TYR A OH  1 
ATOM   1236 N N   . GLY A 1 230 ? 232.345 266.485 376.295 1.00 28.02 ? 230 GLY A N   1 
ATOM   1237 C CA  . GLY A 1 230 ? 232.140 267.213 375.069 1.00 25.68 ? 230 GLY A CA  1 
ATOM   1238 C C   . GLY A 1 230 ? 233.286 268.115 374.661 1.00 25.58 ? 230 GLY A C   1 
ATOM   1239 O O   . GLY A 1 230 ? 233.306 268.585 373.520 1.00 27.38 ? 230 GLY A O   1 
ATOM   1240 N N   . ALA A 1 231 ? 234.240 268.365 375.552 1.00 30.83 ? 231 ALA A N   1 
ATOM   1241 C CA  . ALA A 1 231 ? 235.345 269.267 375.255 1.00 30.86 ? 231 ALA A CA  1 
ATOM   1242 C C   . ALA A 1 231 ? 236.406 268.524 374.456 1.00 27.93 ? 231 ALA A C   1 
ATOM   1243 O O   . ALA A 1 231 ? 236.904 267.481 374.892 1.00 30.89 ? 231 ALA A O   1 
ATOM   1244 C CB  . ALA A 1 231 ? 235.937 269.831 376.543 1.00 26.71 ? 231 ALA A CB  1 
ATOM   1245 N N   . ALA A 1 232 ? 236.742 269.055 373.285 1.00 28.93 ? 232 ALA A N   1 
ATOM   1246 C CA  . ALA A 1 232 ? 237.772 268.475 372.442 1.00 29.73 ? 232 ALA A CA  1 
ATOM   1247 C C   . ALA A 1 232 ? 238.500 269.599 371.725 1.00 27.40 ? 232 ALA A C   1 
ATOM   1248 O O   . ALA A 1 232 ? 237.942 270.676 371.501 1.00 27.31 ? 232 ALA A O   1 
ATOM   1249 C CB  . ALA A 1 232 ? 237.182 267.487 371.430 1.00 27.70 ? 232 ALA A CB  1 
ATOM   1250 N N   . SER A 1 233 ? 239.750 269.339 371.369 1.00 28.18 ? 233 SER A N   1 
ATOM   1251 C CA  . SER A 1 233 ? 240.559 270.324 370.659 1.00 25.10 ? 233 SER A CA  1 
ATOM   1252 C C   . SER A 1 233 ? 240.176 270.457 369.201 1.00 25.61 ? 233 SER A C   1 
ATOM   1253 O O   . SER A 1 233 ? 240.896 271.135 368.464 1.00 30.58 ? 233 SER A O   1 
ATOM   1254 C CB  . SER A 1 233 ? 242.039 269.962 370.772 1.00 25.97 ? 233 SER A CB  1 
ATOM   1255 O OG  . SER A 1 233 ? 242.338 268.785 370.044 1.00 29.13 ? 233 SER A OG  1 
ATOM   1256 N N   . LEU A 1 234 ? 239.088 269.839 368.743 1.00 21.45 ? 234 LEU A N   1 
ATOM   1257 C CA  . LEU A 1 234 ? 238.661 270.012 367.361 1.00 26.86 ? 234 LEU A CA  1 
ATOM   1258 C C   . LEU A 1 234 ? 237.970 271.350 367.124 1.00 25.51 ? 234 LEU A C   1 
ATOM   1259 O O   . LEU A 1 234 ? 237.671 271.674 365.970 1.00 26.70 ? 234 LEU A O   1 
ATOM   1260 C CB  . LEU A 1 234 ? 237.745 268.856 366.935 1.00 25.56 ? 234 LEU A CB  1 
ATOM   1261 C CG  . LEU A 1 234 ? 236.645 268.370 367.886 1.00 31.48 ? 234 LEU A CG  1 
ATOM   1262 C CD1 . LEU A 1 234 ? 235.574 269.429 368.090 1.00 33.65 ? 234 LEU A CD1 1 
ATOM   1263 C CD2 . LEU A 1 234 ? 236.031 267.079 367.369 1.00 24.58 ? 234 LEU A CD2 1 
ATOM   1264 N N   . ASN A 1 235 ? 237.715 272.133 368.175 1.00 26.42 ? 235 ASN A N   1 
ATOM   1265 C CA  . ASN A 1 235 ? 237.196 273.488 368.036 1.00 26.83 ? 235 ASN A CA  1 
ATOM   1266 C C   . ASN A 1 235 ? 238.112 274.510 368.704 1.00 31.13 ? 235 ASN A C   1 
ATOM   1267 O O   . ASN A 1 235 ? 237.652 275.550 369.176 1.00 31.61 ? 235 ASN A O   1 
ATOM   1268 C CB  . ASN A 1 235 ? 235.779 273.591 368.599 1.00 30.96 ? 235 ASN A CB  1 
ATOM   1269 C CG  . ASN A 1 235 ? 235.725 273.364 370.093 1.00 33.91 ? 235 ASN A CG  1 
ATOM   1270 O OD1 . ASN A 1 235 ? 235.234 272.338 370.559 1.00 36.79 ? 235 ASN A OD1 1 
ATOM   1271 N ND2 . ASN A 1 235 ? 236.244 274.318 370.853 1.00 32.85 ? 235 ASN A ND2 1 
ATOM   1272 N N   . ASP A 1 236 ? 239.413 274.232 368.747 1.00 26.69 ? 236 ASP A N   1 
ATOM   1273 C CA  . ASP A 1 236 ? 240.401 275.154 369.298 1.00 23.26 ? 236 ASP A CA  1 
ATOM   1274 C C   . ASP A 1 236 ? 241.060 275.895 368.139 1.00 22.73 ? 236 ASP A C   1 
ATOM   1275 O O   . ASP A 1 236 ? 241.821 275.303 367.369 1.00 29.02 ? 236 ASP A O   1 
ATOM   1276 C CB  . ASP A 1 236 ? 241.436 274.404 370.132 1.00 24.11 ? 236 ASP A CB  1 
ATOM   1277 C CG  . ASP A 1 236 ? 242.430 275.332 370.799 1.00 30.71 ? 236 ASP A CG  1 
ATOM   1278 O OD1 . ASP A 1 236 ? 242.233 276.565 370.737 1.00 27.03 ? 236 ASP A OD1 1 
ATOM   1279 O OD2 . ASP A 1 236 ? 243.411 274.829 371.385 1.00 26.74 ? 236 ASP A OD2 1 
ATOM   1280 N N   . PHE A 1 237 ? 240.774 277.191 368.021 1.00 21.13 ? 237 PHE A N   1 
ATOM   1281 C CA  . PHE A 1 237 ? 241.231 277.982 366.885 1.00 21.04 ? 237 PHE A CA  1 
ATOM   1282 C C   . PHE A 1 237 ? 242.131 279.142 367.286 1.00 17.39 ? 237 PHE A C   1 
ATOM   1283 O O   . PHE A 1 237 ? 242.393 280.016 366.456 1.00 24.41 ? 237 PHE A O   1 
ATOM   1284 C CB  . PHE A 1 237 ? 240.030 278.512 366.102 1.00 22.17 ? 237 PHE A CB  1 
ATOM   1285 C CG  . PHE A 1 237 ? 239.051 277.452 365.718 1.00 20.02 ? 237 PHE A CG  1 
ATOM   1286 C CD1 . PHE A 1 237 ? 239.328 276.579 364.683 1.00 20.96 ? 237 PHE A CD1 1 
ATOM   1287 C CD2 . PHE A 1 237 ? 237.855 277.323 366.395 1.00 20.95 ? 237 PHE A CD2 1 
ATOM   1288 C CE1 . PHE A 1 237 ? 238.429 275.598 364.331 1.00 25.31 ? 237 PHE A CE1 1 
ATOM   1289 C CE2 . PHE A 1 237 ? 236.955 276.346 366.048 1.00 22.22 ? 237 PHE A CE2 1 
ATOM   1290 C CZ  . PHE A 1 237 ? 237.239 275.483 365.014 1.00 23.08 ? 237 PHE A CZ  1 
ATOM   1291 N N   . GLY A 1 238 ? 242.616 279.172 368.517 1.00 13.54 ? 238 GLY A N   1 
ATOM   1292 C CA  . GLY A 1 238 ? 243.445 280.265 368.965 1.00 17.85 ? 238 GLY A CA  1 
ATOM   1293 C C   . GLY A 1 238 ? 242.624 281.417 369.508 1.00 17.63 ? 238 GLY A C   1 
ATOM   1294 O O   . GLY A 1 238 ? 241.463 281.273 369.897 1.00 17.29 ? 238 GLY A O   1 
ATOM   1295 N N   . SER A 1 239 ? 243.251 282.590 369.525 1.00 18.97 ? 239 SER A N   1 
ATOM   1296 C CA  . SER A 1 239 ? 242.652 283.769 370.126 1.00 15.14 ? 239 SER A CA  1 
ATOM   1297 C C   . SER A 1 239 ? 243.004 285.004 369.310 1.00 15.00 ? 239 SER A C   1 
ATOM   1298 O O   . SER A 1 239 ? 243.803 284.960 368.374 1.00 15.20 ? 239 SER A O   1 
ATOM   1299 C CB  . SER A 1 239 ? 243.114 283.950 371.576 1.00 13.25 ? 239 SER A CB  1 
ATOM   1300 O OG  . SER A 1 239 ? 242.693 282.869 372.381 1.00 27.46 ? 239 SER A OG  1 
ATOM   1301 N N   . LEU A 1 240 ? 242.374 286.111 369.679 1.00 18.86 ? 240 LEU A N   1 
ATOM   1302 C CA  . LEU A 1 240 ? 242.714 287.432 369.180 1.00 15.26 ? 240 LEU A CA  1 
ATOM   1303 C C   . LEU A 1 240 ? 243.221 288.262 370.346 1.00 17.77 ? 240 LEU A C   1 
ATOM   1304 O O   . LEU A 1 240 ? 242.550 288.361 371.377 1.00 22.29 ? 240 LEU A O   1 
ATOM   1305 C CB  . LEU A 1 240 ? 241.509 288.118 368.531 1.00 14.43 ? 240 LEU A CB  1 
ATOM   1306 C CG  . LEU A 1 240 ? 240.916 287.456 367.294 1.00 16.04 ? 240 LEU A CG  1 
ATOM   1307 C CD1 . LEU A 1 240 ? 239.808 288.321 366.733 1.00 12.79 ? 240 LEU A CD1 1 
ATOM   1308 C CD2 . LEU A 1 240 ? 241.987 287.197 366.245 1.00 19.94 ? 240 LEU A CD2 1 
ATOM   1309 N N   . ALA A 1 241 ? 244.405 288.838 370.188 1.00 18.80 ? 241 ALA A N   1 
ATOM   1310 C CA  . ALA A 1 241 ? 244.947 289.790 371.144 1.00 17.83 ? 241 ALA A CA  1 
ATOM   1311 C C   . ALA A 1 241 ? 244.797 291.186 370.560 1.00 17.60 ? 241 ALA A C   1 
ATOM   1312 O O   . ALA A 1 241 ? 245.215 291.436 369.428 1.00 19.43 ? 241 ALA A O   1 
ATOM   1313 C CB  . ALA A 1 241 ? 246.411 289.486 371.455 1.00 17.65 ? 241 ALA A CB  1 
ATOM   1314 N N   . VAL A 1 242 ? 244.186 292.084 371.320 1.00 20.34 ? 242 VAL A N   1 
ATOM   1315 C CA  . VAL A 1 242 ? 243.844 293.413 370.835 1.00 17.79 ? 242 VAL A CA  1 
ATOM   1316 C C   . VAL A 1 242 ? 244.466 294.441 371.764 1.00 18.43 ? 242 VAL A C   1 
ATOM   1317 O O   . VAL A 1 242 ? 244.320 294.345 372.987 1.00 23.08 ? 242 VAL A O   1 
ATOM   1318 C CB  . VAL A 1 242 ? 242.319 293.610 370.742 1.00 15.97 ? 242 VAL A CB  1 
ATOM   1319 C CG1 . VAL A 1 242 ? 241.988 295.012 370.270 1.00 24.43 ? 242 VAL A CG1 1 
ATOM   1320 C CG2 . VAL A 1 242 ? 241.715 292.577 369.807 1.00 18.29 ? 242 VAL A CG2 1 
ATOM   1321 N N   . ARG A 1 243 ? 245.160 295.418 371.182 1.00 19.55 ? 243 ARG A N   1 
ATOM   1322 C CA  . ARG A 1 243 ? 245.730 296.522 371.944 1.00 22.10 ? 243 ARG A CA  1 
ATOM   1323 C C   . ARG A 1 243 ? 245.631 297.806 371.134 1.00 19.32 ? 243 ARG A C   1 
ATOM   1324 O O   . ARG A 1 243 ? 245.361 297.792 369.933 1.00 18.97 ? 243 ARG A O   1 
ATOM   1325 C CB  . ARG A 1 243 ? 247.196 296.265 372.329 1.00 18.08 ? 243 ARG A CB  1 
ATOM   1326 C CG  . ARG A 1 243 ? 248.149 296.158 371.149 1.00 15.91 ? 243 ARG A CG  1 
ATOM   1327 C CD  . ARG A 1 243 ? 249.572 296.484 371.545 1.00 15.81 ? 243 ARG A CD  1 
ATOM   1328 N NE  . ARG A 1 243 ? 250.468 296.434 370.397 1.00 21.05 ? 243 ARG A NE  1 
ATOM   1329 C CZ  . ARG A 1 243 ? 251.748 296.777 370.423 1.00 19.71 ? 243 ARG A CZ  1 
ATOM   1330 N NH1 . ARG A 1 243 ? 252.327 297.208 371.530 1.00 23.68 ? 243 ARG A NH1 1 
ATOM   1331 N NH2 . ARG A 1 243 ? 252.463 296.691 369.306 1.00 16.64 ? 243 ARG A NH2 1 
ATOM   1332 N N   . VAL A 1 244 ? 245.857 298.926 371.813 1.00 20.30 ? 244 VAL A N   1 
ATOM   1333 C CA  . VAL A 1 244 ? 246.031 300.216 371.158 1.00 15.54 ? 244 VAL A CA  1 
ATOM   1334 C C   . VAL A 1 244 ? 247.525 300.444 370.966 1.00 22.27 ? 244 VAL A C   1 
ATOM   1335 O O   . VAL A 1 244 ? 248.297 300.405 371.929 1.00 26.96 ? 244 VAL A O   1 
ATOM   1336 C CB  . VAL A 1 244 ? 245.394 301.351 371.976 1.00 23.30 ? 244 VAL A CB  1 
ATOM   1337 C CG1 . VAL A 1 244 ? 245.828 302.707 371.440 1.00 21.72 ? 244 VAL A CG1 1 
ATOM   1338 C CG2 . VAL A 1 244 ? 243.882 301.237 371.952 1.00 24.78 ? 244 VAL A CG2 1 
ATOM   1339 N N   . VAL A 1 245 ? 247.934 300.670 369.716 1.00 21.60 ? 245 VAL A N   1 
ATOM   1340 C CA  . VAL A 1 245 ? 249.352 300.810 369.404 1.00 19.78 ? 245 VAL A CA  1 
ATOM   1341 C C   . VAL A 1 245 ? 249.899 302.136 369.914 1.00 19.74 ? 245 VAL A C   1 
ATOM   1342 O O   . VAL A 1 245 ? 251.069 302.224 370.300 1.00 24.87 ? 245 VAL A O   1 
ATOM   1343 C CB  . VAL A 1 245 ? 249.577 300.658 367.888 1.00 21.26 ? 245 VAL A CB  1 
ATOM   1344 C CG1 . VAL A 1 245 ? 251.045 300.831 367.545 1.00 13.04 ? 245 VAL A CG1 1 
ATOM   1345 C CG2 . VAL A 1 245 ? 249.074 299.309 367.407 1.00 15.63 ? 245 VAL A CG2 1 
ATOM   1346 N N   . ASN A 1 246 ? 249.079 303.183 369.920 1.00 24.73 ? 246 ASN A N   1 
ATOM   1347 C CA  . ASN A 1 246 ? 249.550 304.498 370.329 1.00 23.32 ? 246 ASN A CA  1 
ATOM   1348 C C   . ASN A 1 246 ? 250.063 304.466 371.760 1.00 22.86 ? 246 ASN A C   1 
ATOM   1349 O O   . ASN A 1 246 ? 249.535 303.749 372.612 1.00 32.99 ? 246 ASN A O   1 
ATOM   1350 C CB  . ASN A 1 246 ? 248.426 305.532 370.221 1.00 21.67 ? 246 ASN A CB  1 
ATOM   1351 C CG  . ASN A 1 246 ? 247.832 305.612 368.836 1.00 23.32 ? 246 ASN A CG  1 
ATOM   1352 O OD1 . ASN A 1 246 ? 247.556 304.595 368.206 1.00 21.92 ? 246 ASN A OD1 1 
ATOM   1353 N ND2 . ASN A 1 246 ? 247.637 306.829 368.350 1.00 24.29 ? 246 ASN A ND2 1 
ATOM   1354 N N   . ASP A 1 247 ? 251.100 305.253 372.020 1.00 36.13 ? 247 ASP A N   1 
ATOM   1355 C CA  . ASP A 1 247 ? 251.490 305.513 373.392 1.00 36.42 ? 247 ASP A CA  1 
ATOM   1356 C C   . ASP A 1 247 ? 250.362 306.245 374.108 1.00 40.86 ? 247 ASP A C   1 
ATOM   1357 O O   . ASP A 1 247 ? 249.567 306.967 373.502 1.00 45.54 ? 247 ASP A O   1 
ATOM   1358 C CB  . ASP A 1 247 ? 252.778 306.329 373.445 1.00 38.71 ? 247 ASP A CB  1 
ATOM   1359 C CG  . ASP A 1 247 ? 254.003 305.502 373.119 1.00 42.49 ? 247 ASP A CG  1 
ATOM   1360 O OD1 . ASP A 1 247 ? 254.148 304.397 373.683 1.00 40.43 ? 247 ASP A OD1 1 
ATOM   1361 O OD2 . ASP A 1 247 ? 254.818 305.954 372.292 1.00 44.42 ? 247 ASP A OD2 1 
ATOM   1362 N N   . HIS A 1 248 ? 250.301 306.051 375.416 1.00 46.10 ? 248 HIS A N   1 
ATOM   1363 C CA  . HIS A 1 248 ? 249.109 306.410 376.168 1.00 43.95 ? 248 HIS A CA  1 
ATOM   1364 C C   . HIS A 1 248 ? 248.947 307.922 376.247 1.00 45.18 ? 248 HIS A C   1 
ATOM   1365 O O   . HIS A 1 248 ? 249.896 308.648 376.560 1.00 41.91 ? 248 HIS A O   1 
ATOM   1366 C CB  . HIS A 1 248 ? 249.187 305.798 377.562 1.00 47.22 ? 248 HIS A CB  1 
ATOM   1367 C CG  . HIS A 1 248 ? 249.648 304.375 377.555 1.00 45.58 ? 248 HIS A CG  1 
ATOM   1368 N ND1 . HIS A 1 248 ? 250.840 303.976 378.118 1.00 48.19 ? 248 HIS A ND1 1 
ATOM   1369 C CD2 . HIS A 1 248 ? 249.095 303.262 377.019 1.00 45.29 ? 248 HIS A CD2 1 
ATOM   1370 C CE1 . HIS A 1 248 ? 250.991 302.675 377.948 1.00 48.91 ? 248 HIS A CE1 1 
ATOM   1371 N NE2 . HIS A 1 248 ? 249.945 302.218 377.284 1.00 49.61 ? 248 HIS A NE2 1 
ATOM   1372 N N   . ASN A 1 249 ? 247.734 308.392 375.962 1.00 47.82 ? 249 ASN A N   1 
ATOM   1373 C CA  . ASN A 1 249 ? 247.425 309.805 376.030 1.00 49.15 ? 249 ASN A CA  1 
ATOM   1374 C C   . ASN A 1 249 ? 247.448 310.267 377.481 1.00 48.55 ? 249 ASN A C   1 
ATOM   1375 O O   . ASN A 1 249 ? 247.393 309.455 378.406 1.00 50.49 ? 249 ASN A O   1 
ATOM   1376 C CB  . ASN A 1 249 ? 246.051 310.088 375.419 1.00 49.62 ? 249 ASN A CB  1 
ATOM   1377 C CG  . ASN A 1 249 ? 246.102 310.289 373.915 1.00 54.97 ? 249 ASN A CG  1 
ATOM   1378 O OD1 . ASN A 1 249 ? 245.487 309.537 373.159 1.00 54.52 ? 249 ASN A OD1 1 
ATOM   1379 N ND2 . ASN A 1 249 ? 246.823 311.314 373.474 1.00 46.13 ? 249 ASN A ND2 1 
ATOM   1380 N N   . PRO A 1 250 ? 247.550 311.575 377.714 1.00 47.76 ? 250 PRO A N   1 
ATOM   1381 C CA  . PRO A 1 250 ? 247.288 312.087 379.065 1.00 47.80 ? 250 PRO A CA  1 
ATOM   1382 C C   . PRO A 1 250 ? 245.878 311.788 379.538 1.00 45.19 ? 250 PRO A C   1 
ATOM   1383 O O   . PRO A 1 250 ? 245.650 311.713 380.751 1.00 46.45 ? 250 PRO A O   1 
ATOM   1384 C CB  . PRO A 1 250 ? 247.526 313.598 378.928 1.00 47.73 ? 250 PRO A CB  1 
ATOM   1385 C CG  . PRO A 1 250 ? 248.318 313.762 377.666 1.00 46.38 ? 250 PRO A CG  1 
ATOM   1386 C CD  . PRO A 1 250 ? 247.907 312.647 376.771 1.00 44.00 ? 250 PRO A CD  1 
ATOM   1387 N N   . THR A 1 251 ? 244.934 311.609 378.619 1.00 45.78 ? 251 THR A N   1 
ATOM   1388 C CA  . THR A 1 251 ? 243.543 311.334 378.939 1.00 46.39 ? 251 THR A CA  1 
ATOM   1389 C C   . THR A 1 251 ? 243.218 309.868 378.675 1.00 44.70 ? 251 THR A C   1 
ATOM   1390 O O   . THR A 1 251 ? 243.806 309.227 377.801 1.00 47.46 ? 251 THR A O   1 
ATOM   1391 C CB  . THR A 1 251 ? 242.610 312.232 378.119 1.00 46.48 ? 251 THR A CB  1 
ATOM   1392 O OG1 . THR A 1 251 ? 241.267 312.104 378.600 1.00 49.48 ? 251 THR A OG1 1 
ATOM   1393 C CG2 . THR A 1 251 ? 242.652 311.859 376.643 1.00 44.86 ? 251 THR A CG2 1 
ATOM   1394 N N   . LYS A 1 252 ? 242.265 309.348 379.442 1.00 39.59 ? 252 LYS A N   1 
ATOM   1395 C CA  . LYS A 1 252 ? 241.850 307.955 379.356 1.00 40.02 ? 252 LYS A CA  1 
ATOM   1396 C C   . LYS A 1 252 ? 240.846 307.777 378.222 1.00 42.80 ? 252 LYS A C   1 
ATOM   1397 O O   . LYS A 1 252 ? 239.891 308.550 378.105 1.00 42.33 ? 252 LYS A O   1 
ATOM   1398 C CB  . LYS A 1 252 ? 241.249 307.522 380.697 1.00 42.85 ? 252 LYS A CB  1 
ATOM   1399 C CG  . LYS A 1 252 ? 240.297 306.334 380.669 1.00 43.01 ? 252 LYS A CG  1 
ATOM   1400 C CD  . LYS A 1 252 ? 240.997 305.042 380.327 1.00 43.25 ? 252 LYS A CD  1 
ATOM   1401 C CE  . LYS A 1 252 ? 240.175 303.845 380.758 1.00 45.32 ? 252 LYS A CE  1 
ATOM   1402 N NZ  . LYS A 1 252 ? 240.005 303.794 382.237 1.00 44.74 ? 252 LYS A NZ  1 
ATOM   1403 N N   . LEU A 1 253 ? 241.065 306.762 377.387 1.00 37.01 ? 253 LEU A N   1 
ATOM   1404 C CA  . LEU A 1 253 ? 240.151 306.444 376.298 1.00 33.16 ? 253 LEU A CA  1 
ATOM   1405 C C   . LEU A 1 253 ? 239.717 304.991 376.407 1.00 35.32 ? 253 LEU A C   1 
ATOM   1406 O O   . LEU A 1 253 ? 240.518 304.127 376.767 1.00 36.75 ? 253 LEU A O   1 
ATOM   1407 C CB  . LEU A 1 253 ? 240.794 306.679 374.927 1.00 33.27 ? 253 LEU A CB  1 
ATOM   1408 C CG  . LEU A 1 253 ? 241.181 308.109 374.552 1.00 36.42 ? 253 LEU A CG  1 
ATOM   1409 C CD1 . LEU A 1 253 ? 241.837 308.129 373.187 1.00 34.14 ? 253 LEU A CD1 1 
ATOM   1410 C CD2 . LEU A 1 253 ? 239.971 309.018 374.573 1.00 36.34 ? 253 LEU A CD2 1 
ATOM   1411 N N   . THR A 1 254 ? 238.455 304.720 376.085 1.00 30.27 ? 254 THR A N   1 
ATOM   1412 C CA  . THR A 1 254 ? 237.928 303.362 376.090 1.00 28.57 ? 254 THR A CA  1 
ATOM   1413 C C   . THR A 1 254 ? 237.465 302.997 374.689 1.00 26.04 ? 254 THR A C   1 
ATOM   1414 O O   . THR A 1 254 ? 236.834 303.808 374.008 1.00 32.57 ? 254 THR A O   1 
ATOM   1415 C CB  . THR A 1 254 ? 236.764 303.213 377.076 1.00 35.77 ? 254 THR A CB  1 
ATOM   1416 O OG1 . THR A 1 254 ? 237.230 303.441 378.410 1.00 39.16 ? 254 THR A OG1 1 
ATOM   1417 C CG2 . THR A 1 254 ? 236.161 301.819 376.986 1.00 33.40 ? 254 THR A CG2 1 
ATOM   1418 N N   . SER A 1 255 ? 237.774 301.776 374.258 1.00 17.21 ? 255 SER A N   1 
ATOM   1419 C CA  . SER A 1 255 ? 237.420 301.307 372.930 1.00 16.97 ? 255 SER A CA  1 
ATOM   1420 C C   . SER A 1 255 ? 236.775 299.934 373.017 1.00 22.95 ? 255 SER A C   1 
ATOM   1421 O O   . SER A 1 255 ? 237.103 299.123 373.888 1.00 29.13 ? 255 SER A O   1 
ATOM   1422 C CB  . SER A 1 255 ? 238.647 301.236 372.012 1.00 21.17 ? 255 SER A CB  1 
ATOM   1423 O OG  . SER A 1 255 ? 239.357 302.459 372.011 1.00 29.15 ? 255 SER A OG  1 
ATOM   1424 N N   . LYS A 1 256 ? 235.853 299.684 372.095 1.00 20.65 ? 256 LYS A N   1 
ATOM   1425 C CA  . LYS A 1 256 ? 235.216 298.387 371.939 1.00 17.79 ? 256 LYS A CA  1 
ATOM   1426 C C   . LYS A 1 256 ? 235.313 297.963 370.485 1.00 18.07 ? 256 LYS A C   1 
ATOM   1427 O O   . LYS A 1 256 ? 235.044 298.758 369.576 1.00 25.94 ? 256 LYS A O   1 
ATOM   1428 C CB  . LYS A 1 256 ? 233.757 298.423 372.402 1.00 21.24 ? 256 LYS A CB  1 
ATOM   1429 C CG  . LYS A 1 256 ? 233.620 298.767 373.870 1.00 24.40 ? 256 LYS A CG  1 
ATOM   1430 C CD  . LYS A 1 256 ? 232.298 298.334 374.444 1.00 22.68 ? 256 LYS A CD  1 
ATOM   1431 C CE  . LYS A 1 256 ? 232.306 298.436 375.957 1.00 28.28 ? 256 LYS A CE  1 
ATOM   1432 N NZ  . LYS A 1 256 ? 230.958 298.216 376.539 1.00 27.73 ? 256 LYS A NZ  1 
ATOM   1433 N N   . ILE A 1 257 ? 235.725 296.718 370.276 1.00 14.44 ? 257 ILE A N   1 
ATOM   1434 C CA  . ILE A 1 257 ? 235.818 296.103 368.961 1.00 16.12 ? 257 ILE A CA  1 
ATOM   1435 C C   . ILE A 1 257 ? 234.750 295.021 368.897 1.00 19.10 ? 257 ILE A C   1 
ATOM   1436 O O   . ILE A 1 257 ? 234.791 294.051 369.662 1.00 21.14 ? 257 ILE A O   1 
ATOM   1437 C CB  . ILE A 1 257 ? 237.216 295.517 368.700 1.00 18.63 ? 257 ILE A CB  1 
ATOM   1438 C CG1 . ILE A 1 257 ? 238.288 296.612 368.728 1.00 21.07 ? 257 ILE A CG1 1 
ATOM   1439 C CG2 . ILE A 1 257 ? 237.254 294.797 367.360 1.00 21.96 ? 257 ILE A CG2 1 
ATOM   1440 C CD1 . ILE A 1 257 ? 238.733 297.024 370.113 1.00 20.68 ? 257 ILE A CD1 1 
ATOM   1441 N N   . ARG A 1 258 ? 233.789 295.192 368.001 1.00 17.08 ? 258 ARG A N   1 
ATOM   1442 C CA  . ARG A 1 258 ? 232.738 294.214 367.779 1.00 12.76 ? 258 ARG A CA  1 
ATOM   1443 C C   . ARG A 1 258 ? 233.135 293.325 366.612 1.00 17.25 ? 258 ARG A C   1 
ATOM   1444 O O   . ARG A 1 258 ? 233.507 293.823 365.543 1.00 19.22 ? 258 ARG A O   1 
ATOM   1445 C CB  . ARG A 1 258 ? 231.401 294.903 367.506 1.00 13.90 ? 258 ARG A CB  1 
ATOM   1446 C CG  . ARG A 1 258 ? 230.693 295.365 368.761 1.00 18.48 ? 258 ARG A CG  1 
ATOM   1447 C CD  . ARG A 1 258 ? 229.629 296.399 368.469 1.00 9.96  ? 258 ARG A CD  1 
ATOM   1448 N NE  . ARG A 1 258 ? 228.797 296.666 369.634 1.00 11.78 ? 258 ARG A NE  1 
ATOM   1449 C CZ  . ARG A 1 258 ? 229.110 297.505 370.611 1.00 12.88 ? 258 ARG A CZ  1 
ATOM   1450 N NH1 . ARG A 1 258 ? 230.247 298.178 370.608 1.00 20.62 ? 258 ARG A NH1 1 
ATOM   1451 N NH2 . ARG A 1 258 ? 228.260 297.673 371.617 1.00 19.29 ? 258 ARG A NH2 1 
ATOM   1452 N N   . VAL A 1 259 ? 233.064 292.015 366.831 1.00 16.45 ? 259 VAL A N   1 
ATOM   1453 C CA  . VAL A 1 259 ? 233.468 291.021 365.846 1.00 12.39 ? 259 VAL A CA  1 
ATOM   1454 C C   . VAL A 1 259 ? 232.215 290.441 365.208 1.00 10.31 ? 259 VAL A C   1 
ATOM   1455 O O   . VAL A 1 259 ? 231.305 289.988 365.910 1.00 19.74 ? 259 VAL A O   1 
ATOM   1456 C CB  . VAL A 1 259 ? 234.323 289.914 366.490 1.00 17.83 ? 259 VAL A CB  1 
ATOM   1457 C CG1 . VAL A 1 259 ? 234.870 288.977 365.432 1.00 13.43 ? 259 VAL A CG1 1 
ATOM   1458 C CG2 . VAL A 1 259 ? 235.451 290.518 367.305 1.00 14.11 ? 259 VAL A CG2 1 
ATOM   1459 N N   . TYR A 1 260 ? 232.162 290.462 363.882 1.00 9.75  ? 260 TYR A N   1 
ATOM   1460 C CA  . TYR A 1 260 ? 231.033 289.952 363.123 1.00 13.45 ? 260 TYR A CA  1 
ATOM   1461 C C   . TYR A 1 260 ? 231.513 288.821 362.229 1.00 14.04 ? 260 TYR A C   1 
ATOM   1462 O O   . TYR A 1 260 ? 232.458 288.999 361.453 1.00 17.69 ? 260 TYR A O   1 
ATOM   1463 C CB  . TYR A 1 260 ? 230.379 291.065 362.294 1.00 14.84 ? 260 TYR A CB  1 
ATOM   1464 C CG  . TYR A 1 260 ? 229.698 292.109 363.146 1.00 8.29  ? 260 TYR A CG  1 
ATOM   1465 C CD1 . TYR A 1 260 ? 230.428 293.114 363.763 1.00 15.00 ? 260 TYR A CD1 1 
ATOM   1466 C CD2 . TYR A 1 260 ? 228.326 292.082 363.342 1.00 13.45 ? 260 TYR A CD2 1 
ATOM   1467 C CE1 . TYR A 1 260 ? 229.812 294.061 364.550 1.00 12.44 ? 260 TYR A CE1 1 
ATOM   1468 C CE2 . TYR A 1 260 ? 227.702 293.025 364.126 1.00 10.61 ? 260 TYR A CE2 1 
ATOM   1469 C CZ  . TYR A 1 260 ? 228.451 294.012 364.731 1.00 14.24 ? 260 TYR A CZ  1 
ATOM   1470 O OH  . TYR A 1 260 ? 227.836 294.953 365.517 1.00 20.95 ? 260 TYR A OH  1 
ATOM   1471 N N   . MET A 1 261 ? 230.867 287.664 362.351 1.00 14.83 ? 261 MET A N   1 
ATOM   1472 C CA  . MET A 1 261 ? 231.200 286.465 361.596 1.00 10.39 ? 261 MET A CA  1 
ATOM   1473 C C   . MET A 1 261 ? 230.202 286.262 360.469 1.00 17.60 ? 261 MET A C   1 
ATOM   1474 O O   . MET A 1 261 ? 228.999 286.454 360.654 1.00 27.15 ? 261 MET A O   1 
ATOM   1475 C CB  . MET A 1 261 ? 231.184 285.222 362.489 1.00 18.55 ? 261 MET A CB  1 
ATOM   1476 C CG  . MET A 1 261 ? 232.439 284.968 363.288 1.00 18.60 ? 261 MET A CG  1 
ATOM   1477 S SD  . MET A 1 261 ? 232.335 283.399 364.174 1.00 42.57 ? 261 MET A SD  1 
ATOM   1478 C CE  . MET A 1 261 ? 233.841 283.437 365.136 1.00 24.41 ? 261 MET A CE  1 
ATOM   1479 N N   . LYS A 1 262 ? 230.704 285.864 359.304 1.00 10.81 ? 262 LYS A N   1 
ATOM   1480 C CA  . LYS A 1 262 ? 229.854 285.434 358.197 1.00 15.25 ? 262 LYS A CA  1 
ATOM   1481 C C   . LYS A 1 262 ? 230.435 284.160 357.593 1.00 14.27 ? 262 LYS A C   1 
ATOM   1482 O O   . LYS A 1 262 ? 231.515 284.200 356.979 1.00 18.12 ? 262 LYS A O   1 
ATOM   1483 C CB  . LYS A 1 262 ? 229.712 286.518 357.135 1.00 14.82 ? 262 LYS A CB  1 
ATOM   1484 C CG  . LYS A 1 262 ? 228.606 286.219 356.132 1.00 16.45 ? 262 LYS A CG  1 
ATOM   1485 C CD  . LYS A 1 262 ? 228.478 287.279 355.053 1.00 18.23 ? 262 LYS A CD  1 
ATOM   1486 C CE  . LYS A 1 262 ? 229.647 287.248 354.091 1.00 23.78 ? 262 LYS A CE  1 
ATOM   1487 N NZ  . LYS A 1 262 ? 229.353 287.978 352.831 1.00 22.14 ? 262 LYS A NZ  1 
ATOM   1488 N N   . PRO A 1 263 ? 229.784 283.013 357.781 1.00 15.81 ? 263 PRO A N   1 
ATOM   1489 C CA  . PRO A 1 263 ? 230.198 281.811 357.048 1.00 22.16 ? 263 PRO A CA  1 
ATOM   1490 C C   . PRO A 1 263 ? 229.923 281.952 355.559 1.00 18.16 ? 263 PRO A C   1 
ATOM   1491 O O   . PRO A 1 263 ? 228.941 282.570 355.146 1.00 22.60 ? 263 PRO A O   1 
ATOM   1492 C CB  . PRO A 1 263 ? 229.353 280.698 357.678 1.00 16.27 ? 263 PRO A CB  1 
ATOM   1493 C CG  . PRO A 1 263 ? 228.902 281.240 358.984 1.00 16.18 ? 263 PRO A CG  1 
ATOM   1494 C CD  . PRO A 1 263 ? 228.756 282.709 358.788 1.00 14.66 ? 263 PRO A CD  1 
ATOM   1495 N N   . LYS A 1 264 ? 230.795 281.357 354.754 1.00 18.19 ? 264 LYS A N   1 
ATOM   1496 C CA  . LYS A 1 264 ? 230.700 281.423 353.306 1.00 16.42 ? 264 LYS A CA  1 
ATOM   1497 C C   . LYS A 1 264 ? 231.005 280.054 352.722 1.00 17.05 ? 264 LYS A C   1 
ATOM   1498 O O   . LYS A 1 264 ? 231.803 279.292 353.271 1.00 15.42 ? 264 LYS A O   1 
ATOM   1499 C CB  . LYS A 1 264 ? 231.668 282.460 352.720 1.00 24.66 ? 264 LYS A CB  1 
ATOM   1500 C CG  . LYS A 1 264 ? 231.440 283.873 353.212 1.00 24.79 ? 264 LYS A CG  1 
ATOM   1501 C CD  . LYS A 1 264 ? 232.429 284.853 352.599 1.00 23.91 ? 264 LYS A CD  1 
ATOM   1502 C CE  . LYS A 1 264 ? 232.296 284.921 351.085 1.00 25.75 ? 264 LYS A CE  1 
ATOM   1503 N NZ  . LYS A 1 264 ? 233.096 286.028 350.503 1.00 30.56 ? 264 LYS A NZ  1 
ATOM   1504 N N   . HIS A 1 265 ? 230.372 279.759 351.588 1.00 23.17 ? 265 HIS A N   1 
ATOM   1505 C CA  . HIS A 1 265 ? 230.524 278.466 350.923 1.00 17.65 ? 265 HIS A CA  1 
ATOM   1506 C C   . HIS A 1 265 ? 230.187 277.333 351.890 1.00 18.82 ? 265 HIS A C   1 
ATOM   1507 O O   . HIS A 1 265 ? 230.981 276.423 352.128 1.00 22.84 ? 265 HIS A O   1 
ATOM   1508 C CB  . HIS A 1 265 ? 231.935 278.314 350.354 1.00 19.06 ? 265 HIS A CB  1 
ATOM   1509 C CG  . HIS A 1 265 ? 232.397 279.504 349.572 1.00 24.25 ? 265 HIS A CG  1 
ATOM   1510 N ND1 . HIS A 1 265 ? 233.295 280.421 350.074 1.00 26.73 ? 265 HIS A ND1 1 
ATOM   1511 C CD2 . HIS A 1 265 ? 232.072 279.937 348.332 1.00 24.50 ? 265 HIS A CD2 1 
ATOM   1512 C CE1 . HIS A 1 265 ? 233.510 281.362 349.174 1.00 25.41 ? 265 HIS A CE1 1 
ATOM   1513 N NE2 . HIS A 1 265 ? 232.780 281.092 348.107 1.00 22.69 ? 265 HIS A NE2 1 
ATOM   1514 N N   . VAL A 1 266 ? 228.987 277.401 352.448 1.00 13.88 ? 266 VAL A N   1 
ATOM   1515 C CA  . VAL A 1 266 ? 228.604 276.564 353.577 1.00 15.05 ? 266 VAL A CA  1 
ATOM   1516 C C   . VAL A 1 266 ? 228.109 275.211 353.088 1.00 17.31 ? 266 VAL A C   1 
ATOM   1517 O O   . VAL A 1 266 ? 227.363 275.113 352.107 1.00 18.06 ? 266 VAL A O   1 
ATOM   1518 C CB  . VAL A 1 266 ? 227.532 277.273 354.423 1.00 15.82 ? 266 VAL A CB  1 
ATOM   1519 C CG1 . VAL A 1 266 ? 227.143 276.421 355.617 1.00 20.18 ? 266 VAL A CG1 1 
ATOM   1520 C CG2 . VAL A 1 266 ? 228.028 278.637 354.874 1.00 20.80 ? 266 VAL A CG2 1 
ATOM   1521 N N   . ARG A 1 267 ? 228.541 274.158 353.774 1.00 5.65  ? 267 ARG A N   1 
ATOM   1522 C CA  . ARG A 1 267 ? 227.972 272.825 353.641 1.00 11.48 ? 267 ARG A CA  1 
ATOM   1523 C C   . ARG A 1 267 ? 227.638 272.336 355.039 1.00 10.41 ? 267 ARG A C   1 
ATOM   1524 O O   . ARG A 1 267 ? 228.408 272.568 355.971 1.00 11.87 ? 267 ARG A O   1 
ATOM   1525 C CB  . ARG A 1 267 ? 228.941 271.864 352.948 1.00 13.62 ? 267 ARG A CB  1 
ATOM   1526 C CG  . ARG A 1 267 ? 229.244 272.233 351.513 1.00 7.71  ? 267 ARG A CG  1 
ATOM   1527 C CD  . ARG A 1 267 ? 230.187 271.244 350.867 1.00 14.32 ? 267 ARG A CD  1 
ATOM   1528 N NE  . ARG A 1 267 ? 229.582 269.931 350.692 1.00 16.24 ? 267 ARG A NE  1 
ATOM   1529 C CZ  . ARG A 1 267 ? 230.230 268.860 350.257 1.00 12.77 ? 267 ARG A CZ  1 
ATOM   1530 N NH1 . ARG A 1 267 ? 231.515 268.906 349.951 1.00 17.32 ? 267 ARG A NH1 1 
ATOM   1531 N NH2 . ARG A 1 267 ? 229.572 267.712 350.126 1.00 15.22 ? 267 ARG A NH2 1 
ATOM   1532 N N   . VAL A 1 268 ? 226.486 271.686 355.193 1.00 15.03 ? 268 VAL A N   1 
ATOM   1533 C CA  . VAL A 1 268 ? 226.009 271.251 356.501 1.00 12.58 ? 268 VAL A CA  1 
ATOM   1534 C C   . VAL A 1 268 ? 225.484 269.826 356.406 1.00 7.65  ? 268 VAL A C   1 
ATOM   1535 O O   . VAL A 1 268 ? 225.076 269.359 355.339 1.00 6.28  ? 268 VAL A O   1 
ATOM   1536 C CB  . VAL A 1 268 ? 224.917 272.191 357.067 1.00 14.94 ? 268 VAL A CB  1 
ATOM   1537 C CG1 . VAL A 1 268 ? 225.536 273.456 357.614 1.00 8.36  ? 268 VAL A CG1 1 
ATOM   1538 C CG2 . VAL A 1 268 ? 223.870 272.512 356.008 1.00 10.45 ? 268 VAL A CG2 1 
ATOM   1539 N N   . TRP A 1 269 ? 225.506 269.132 357.540 1.00 9.92  ? 269 TRP A N   1 
ATOM   1540 C CA  . TRP A 1 269 ? 225.081 267.743 357.616 1.00 8.32  ? 269 TRP A CA  1 
ATOM   1541 C C   . TRP A 1 269 ? 224.360 267.486 358.927 1.00 9.88  ? 269 TRP A C   1 
ATOM   1542 O O   . TRP A 1 269 ? 224.704 268.055 359.973 1.00 16.63 ? 269 TRP A O   1 
ATOM   1543 C CB  . TRP A 1 269 ? 226.251 266.751 357.533 1.00 8.56  ? 269 TRP A CB  1 
ATOM   1544 C CG  . TRP A 1 269 ? 227.012 266.755 356.258 1.00 9.45  ? 269 TRP A CG  1 
ATOM   1545 C CD1 . TRP A 1 269 ? 226.814 265.944 355.184 1.00 2.48  ? 269 TRP A CD1 1 
ATOM   1546 C CD2 . TRP A 1 269 ? 228.118 267.597 355.927 1.00 12.16 ? 269 TRP A CD2 1 
ATOM   1547 N NE1 . TRP A 1 269 ? 227.722 266.231 354.201 1.00 5.68  ? 269 TRP A NE1 1 
ATOM   1548 C CE2 . TRP A 1 269 ? 228.535 267.245 354.633 1.00 12.33 ? 269 TRP A CE2 1 
ATOM   1549 C CE3 . TRP A 1 269 ? 228.793 268.619 356.598 1.00 8.49  ? 269 TRP A CE3 1 
ATOM   1550 C CZ2 . TRP A 1 269 ? 229.597 267.879 353.995 1.00 10.31 ? 269 TRP A CZ2 1 
ATOM   1551 C CZ3 . TRP A 1 269 ? 229.843 269.245 355.965 1.00 11.26 ? 269 TRP A CZ3 1 
ATOM   1552 C CH2 . TRP A 1 269 ? 230.235 268.874 354.677 1.00 10.62 ? 269 TRP A CH2 1 
ATOM   1553 N N   . CYS A 1 270 ? 223.410 266.540 358.857 1.00 13.59 ? 270 CYS A N   1 
ATOM   1554 C CA  . CYS A 1 270 ? 222.685 265.954 359.980 1.00 6.92  ? 270 CYS A CA  1 
ATOM   1555 C C   . CYS A 1 270 ? 221.846 266.978 360.737 1.00 10.80 ? 270 CYS A C   1 
ATOM   1556 O O   . CYS A 1 270 ? 222.213 267.401 361.839 1.00 10.19 ? 270 CYS A O   1 
ATOM   1557 C CB  . CYS A 1 270 ? 223.670 265.253 360.913 1.00 8.35  ? 270 CYS A CB  1 
ATOM   1558 S SG  . CYS A 1 270 ? 224.467 263.826 360.149 1.00 19.55 ? 270 CYS A SG  1 
ATOM   1559 N N   . PRO A 1 271 ? 220.718 267.404 360.169 1.00 14.34 ? 271 PRO A N   1 
ATOM   1560 C CA  . PRO A 1 271 ? 219.885 268.412 360.836 1.00 9.97  ? 271 PRO A CA  1 
ATOM   1561 C C   . PRO A 1 271 ? 219.417 267.960 362.211 1.00 5.11  ? 271 PRO A C   1 
ATOM   1562 O O   . PRO A 1 271 ? 219.145 266.783 362.444 1.00 11.78 ? 271 PRO A O   1 
ATOM   1563 C CB  . PRO A 1 271 ? 218.707 268.588 359.874 1.00 6.99  ? 271 PRO A CB  1 
ATOM   1564 C CG  . PRO A 1 271 ? 218.667 267.341 359.080 1.00 4.46  ? 271 PRO A CG  1 
ATOM   1565 C CD  . PRO A 1 271 ? 220.080 266.882 358.949 1.00 7.59  ? 271 PRO A CD  1 
ATOM   1566 N N   . ARG A 1 272 ? 219.325 268.920 363.122 1.00 8.75  ? 272 ARG A N   1 
ATOM   1567 C CA  . ARG A 1 272 ? 218.899 268.701 364.488 1.00 3.49  ? 272 ARG A CA  1 
ATOM   1568 C C   . ARG A 1 272 ? 217.725 269.616 364.812 1.00 11.33 ? 272 ARG A C   1 
ATOM   1569 O O   . ARG A 1 272 ? 217.549 270.652 364.167 1.00 18.06 ? 272 ARG A O   1 
ATOM   1570 C CB  . ARG A 1 272 ? 220.041 268.979 365.475 1.00 8.02  ? 272 ARG A CB  1 
ATOM   1571 C CG  . ARG A 1 272 ? 221.373 268.369 365.074 1.00 7.70  ? 272 ARG A CG  1 
ATOM   1572 C CD  . ARG A 1 272 ? 222.486 268.770 366.015 1.00 8.67  ? 272 ARG A CD  1 
ATOM   1573 N NE  . ARG A 1 272 ? 222.358 268.181 367.344 1.00 4.87  ? 272 ARG A NE  1 
ATOM   1574 C CZ  . ARG A 1 272 ? 222.823 266.987 367.689 1.00 6.09  ? 272 ARG A CZ  1 
ATOM   1575 N NH1 . ARG A 1 272 ? 223.414 266.192 366.814 1.00 3.16  ? 272 ARG A NH1 1 
ATOM   1576 N NH2 . ARG A 1 272 ? 222.702 266.585 368.949 1.00 5.20  ? 272 ARG A NH2 1 
ATOM   1577 N N   . PRO A 1 273 ? 216.893 269.255 365.784 1.00 15.78 ? 273 PRO A N   1 
ATOM   1578 C CA  . PRO A 1 273 ? 215.862 270.183 366.254 1.00 15.04 ? 273 PRO A CA  1 
ATOM   1579 C C   . PRO A 1 273 ? 216.491 271.422 366.865 1.00 8.74  ? 273 PRO A C   1 
ATOM   1580 O O   . PRO A 1 273 ? 217.535 271.334 367.527 1.00 19.85 ? 273 PRO A O   1 
ATOM   1581 C CB  . PRO A 1 273 ? 215.094 269.363 367.302 1.00 6.65  ? 273 PRO A CB  1 
ATOM   1582 C CG  . PRO A 1 273 ? 216.010 268.276 367.692 1.00 8.25  ? 273 PRO A CG  1 
ATOM   1583 C CD  . PRO A 1 273 ? 216.843 267.970 366.498 1.00 9.29  ? 273 PRO A CD  1 
ATOM   1584 N N   . PRO A 1 274 ? 215.895 272.596 366.668 1.00 19.96 ? 274 PRO A N   1 
ATOM   1585 C CA  . PRO A 1 274 ? 216.502 273.822 367.198 1.00 14.91 ? 274 PRO A CA  1 
ATOM   1586 C C   . PRO A 1 274 ? 216.404 273.918 368.711 1.00 12.10 ? 274 PRO A C   1 
ATOM   1587 O O   . PRO A 1 274 ? 215.542 273.310 369.346 1.00 23.09 ? 274 PRO A O   1 
ATOM   1588 C CB  . PRO A 1 274 ? 215.699 274.937 366.519 1.00 14.66 ? 274 PRO A CB  1 
ATOM   1589 C CG  . PRO A 1 274 ? 214.404 274.314 366.174 1.00 15.59 ? 274 PRO A CG  1 
ATOM   1590 C CD  . PRO A 1 274 ? 214.690 272.880 365.870 1.00 14.47 ? 274 PRO A CD  1 
ATOM   1591 N N   . ARG A 1 275 ? 217.310 274.707 369.283 1.00 15.52 ? 275 ARG A N   1 
ATOM   1592 C CA  . ARG A 1 275 ? 217.313 274.950 370.718 1.00 13.69 ? 275 ARG A CA  1 
ATOM   1593 C C   . ARG A 1 275 ? 215.984 275.551 371.156 1.00 14.82 ? 275 ARG A C   1 
ATOM   1594 O O   . ARG A 1 275 ? 215.496 276.513 370.558 1.00 19.19 ? 275 ARG A O   1 
ATOM   1595 C CB  . ARG A 1 275 ? 218.467 275.888 371.079 1.00 16.19 ? 275 ARG A CB  1 
ATOM   1596 C CG  . ARG A 1 275 ? 218.651 276.139 372.567 1.00 15.14 ? 275 ARG A CG  1 
ATOM   1597 C CD  . ARG A 1 275 ? 219.287 274.954 373.273 1.00 10.76 ? 275 ARG A CD  1 
ATOM   1598 N NE  . ARG A 1 275 ? 219.463 275.202 374.699 1.00 12.58 ? 275 ARG A NE  1 
ATOM   1599 C CZ  . ARG A 1 275 ? 220.105 274.392 375.531 1.00 11.64 ? 275 ARG A CZ  1 
ATOM   1600 N NH1 . ARG A 1 275 ? 220.641 273.258 375.116 1.00 18.60 ? 275 ARG A NH1 1 
ATOM   1601 N NH2 . ARG A 1 275 ? 220.214 274.732 376.810 1.00 12.44 ? 275 ARG A NH2 1 
ATOM   1602 N N   . ALA A 1 276 ? 215.402 274.989 372.216 1.00 20.38 ? 276 ALA A N   1 
ATOM   1603 C CA  . ALA A 1 276 ? 214.102 275.423 372.704 1.00 19.32 ? 276 ALA A CA  1 
ATOM   1604 C C   . ALA A 1 276 ? 214.158 276.164 374.029 1.00 23.45 ? 276 ALA A C   1 
ATOM   1605 O O   . ALA A 1 276 ? 213.201 276.867 374.360 1.00 27.93 ? 276 ALA A O   1 
ATOM   1606 C CB  . ALA A 1 276 ? 213.161 274.221 372.856 1.00 11.89 ? 276 ALA A CB  1 
ATOM   1607 N N   . VAL A 1 277 ? 215.236 276.029 374.787 1.00 22.63 ? 277 VAL A N   1 
ATOM   1608 C CA  . VAL A 1 277 ? 215.356 276.669 376.094 1.00 20.43 ? 277 VAL A CA  1 
ATOM   1609 C C   . VAL A 1 277 ? 216.656 277.460 376.100 1.00 18.72 ? 277 VAL A C   1 
ATOM   1610 O O   . VAL A 1 277 ? 217.528 277.255 375.241 1.00 24.65 ? 277 VAL A O   1 
ATOM   1611 C CB  . VAL A 1 277 ? 215.299 275.639 377.246 1.00 22.94 ? 277 VAL A CB  1 
ATOM   1612 C CG1 . VAL A 1 277 ? 213.944 274.956 377.275 1.00 21.45 ? 277 VAL A CG1 1 
ATOM   1613 C CG2 . VAL A 1 277 ? 216.411 274.613 377.112 1.00 19.70 ? 277 VAL A CG2 1 
ATOM   1614 N N   . PRO A 1 278 ? 216.815 278.385 377.044 1.00 24.13 ? 278 PRO A N   1 
ATOM   1615 C CA  . PRO A 1 278 ? 218.024 279.217 377.060 1.00 15.84 ? 278 PRO A CA  1 
ATOM   1616 C C   . PRO A 1 278 ? 219.297 278.385 377.128 1.00 16.95 ? 278 PRO A C   1 
ATOM   1617 O O   . PRO A 1 278 ? 219.365 277.369 377.822 1.00 26.11 ? 278 PRO A O   1 
ATOM   1618 C CB  . PRO A 1 278 ? 217.847 280.070 378.320 1.00 17.98 ? 278 PRO A CB  1 
ATOM   1619 C CG  . PRO A 1 278 ? 216.387 280.099 378.560 1.00 14.20 ? 278 PRO A CG  1 
ATOM   1620 C CD  . PRO A 1 278 ? 215.849 278.795 378.076 1.00 21.98 ? 278 PRO A CD  1 
ATOM   1621 N N   . TYR A 1 279 ? 220.313 278.832 376.397 1.00 20.48 ? 279 TYR A N   1 
ATOM   1622 C CA  . TYR A 1 279 ? 221.618 278.194 376.463 1.00 16.91 ? 279 TYR A CA  1 
ATOM   1623 C C   . TYR A 1 279 ? 222.228 278.371 377.847 1.00 21.41 ? 279 TYR A C   1 
ATOM   1624 O O   . TYR A 1 279 ? 221.993 279.367 378.535 1.00 28.91 ? 279 TYR A O   1 
ATOM   1625 C CB  . TYR A 1 279 ? 222.559 278.775 375.408 1.00 13.75 ? 279 TYR A CB  1 
ATOM   1626 C CG  . TYR A 1 279 ? 222.352 278.224 374.019 1.00 13.89 ? 279 TYR A CG  1 
ATOM   1627 C CD1 . TYR A 1 279 ? 222.648 276.902 373.726 1.00 10.62 ? 279 TYR A CD1 1 
ATOM   1628 C CD2 . TYR A 1 279 ? 221.878 279.031 372.996 1.00 13.18 ? 279 TYR A CD2 1 
ATOM   1629 C CE1 . TYR A 1 279 ? 222.466 276.399 372.460 1.00 6.84  ? 279 TYR A CE1 1 
ATOM   1630 C CE2 . TYR A 1 279 ? 221.696 278.535 371.726 1.00 11.17 ? 279 TYR A CE2 1 
ATOM   1631 C CZ  . TYR A 1 279 ? 221.990 277.220 371.463 1.00 10.75 ? 279 TYR A CZ  1 
ATOM   1632 O OH  . TYR A 1 279 ? 221.809 276.723 370.197 1.00 17.95 ? 279 TYR A OH  1 
ATOM   1633 N N   . TYR A 1 280 ? 223.013 277.378 378.258 1.00 22.56 ? 280 TYR A N   1 
ATOM   1634 C CA  . TYR A 1 280 ? 223.701 277.391 379.550 1.00 24.47 ? 280 TYR A CA  1 
ATOM   1635 C C   . TYR A 1 280 ? 225.072 276.755 379.330 1.00 25.42 ? 280 TYR A C   1 
ATOM   1636 O O   . TYR A 1 280 ? 225.221 275.533 379.395 1.00 30.42 ? 280 TYR A O   1 
ATOM   1637 C CB  . TYR A 1 280 ? 222.894 276.658 380.612 1.00 24.93 ? 280 TYR A CB  1 
ATOM   1638 C CG  . TYR A 1 280 ? 223.458 276.783 382.008 1.00 29.58 ? 280 TYR A CG  1 
ATOM   1639 C CD1 . TYR A 1 280 ? 223.437 277.996 382.678 1.00 27.98 ? 280 TYR A CD1 1 
ATOM   1640 C CD2 . TYR A 1 280 ? 223.996 275.685 382.662 1.00 29.33 ? 280 TYR A CD2 1 
ATOM   1641 C CE1 . TYR A 1 280 ? 223.943 278.116 383.953 1.00 26.84 ? 280 TYR A CE1 1 
ATOM   1642 C CE2 . TYR A 1 280 ? 224.507 275.796 383.941 1.00 26.70 ? 280 TYR A CE2 1 
ATOM   1643 C CZ  . TYR A 1 280 ? 224.477 277.014 384.580 1.00 29.69 ? 280 TYR A CZ  1 
ATOM   1644 O OH  . TYR A 1 280 ? 224.982 277.134 385.853 1.00 34.57 ? 280 TYR A OH  1 
ATOM   1645 N N   . GLY A 1 281 ? 226.069 277.593 379.066 1.00 22.03 ? 281 GLY A N   1 
ATOM   1646 C CA  . GLY A 1 281 ? 227.417 277.130 378.851 1.00 24.83 ? 281 GLY A CA  1 
ATOM   1647 C C   . GLY A 1 281 ? 227.675 276.722 377.416 1.00 23.78 ? 281 GLY A C   1 
ATOM   1648 O O   . GLY A 1 281 ? 226.791 276.787 376.558 1.00 22.50 ? 281 GLY A O   1 
ATOM   1649 N N   . PRO A 1 282 ? 228.906 276.295 377.126 1.00 20.64 ? 282 PRO A N   1 
ATOM   1650 C CA  . PRO A 1 282 ? 229.245 275.890 375.752 1.00 22.70 ? 282 PRO A CA  1 
ATOM   1651 C C   . PRO A 1 282 ? 228.643 274.561 375.328 1.00 21.60 ? 282 PRO A C   1 
ATOM   1652 O O   . PRO A 1 282 ? 228.713 274.231 374.138 1.00 24.04 ? 282 PRO A O   1 
ATOM   1653 C CB  . PRO A 1 282 ? 230.779 275.810 375.775 1.00 23.92 ? 282 PRO A CB  1 
ATOM   1654 C CG  . PRO A 1 282 ? 231.199 276.490 377.033 1.00 25.54 ? 282 PRO A CG  1 
ATOM   1655 C CD  . PRO A 1 282 ? 230.090 276.314 377.997 1.00 25.22 ? 282 PRO A CD  1 
ATOM   1656 N N   . GLY A 1 283 ? 228.077 273.790 376.243 1.00 22.54 ? 283 GLY A N   1 
ATOM   1657 C CA  . GLY A 1 283 ? 227.485 272.506 375.925 1.00 15.79 ? 283 GLY A CA  1 
ATOM   1658 C C   . GLY A 1 283 ? 226.005 272.604 375.633 1.00 22.68 ? 283 GLY A C   1 
ATOM   1659 O O   . GLY A 1 283 ? 225.498 273.643 375.200 1.00 29.88 ? 283 GLY A O   1 
ATOM   1660 N N   . VAL A 1 284 ? 225.298 271.504 375.878 1.00 19.27 ? 284 VAL A N   1 
ATOM   1661 C CA  . VAL A 1 284 ? 223.859 271.429 375.669 1.00 20.08 ? 284 VAL A CA  1 
ATOM   1662 C C   . VAL A 1 284 ? 223.098 271.482 376.987 1.00 24.56 ? 284 VAL A C   1 
ATOM   1663 O O   . VAL A 1 284 ? 221.890 271.231 377.011 1.00 26.21 ? 284 VAL A O   1 
ATOM   1664 C CB  . VAL A 1 284 ? 223.476 270.172 374.870 1.00 19.87 ? 284 VAL A CB  1 
ATOM   1665 C CG1 . VAL A 1 284 ? 224.370 270.021 373.655 1.00 17.94 ? 284 VAL A CG1 1 
ATOM   1666 C CG2 . VAL A 1 284 ? 223.539 268.931 375.750 1.00 12.37 ? 284 VAL A CG2 1 
ATOM   1667 N N   . ASP A 1 285 ? 223.773 271.803 378.084 1.00 15.53 ? 285 ASP A N   1 
ATOM   1668 C CA  . ASP A 1 285 ? 223.121 271.831 379.383 1.00 19.28 ? 285 ASP A CA  1 
ATOM   1669 C C   . ASP A 1 285 ? 222.062 272.925 379.434 1.00 18.54 ? 285 ASP A C   1 
ATOM   1670 O O   . ASP A 1 285 ? 222.158 273.951 378.758 1.00 30.99 ? 285 ASP A O   1 
ATOM   1671 C CB  . ASP A 1 285 ? 224.154 272.056 380.487 1.00 21.43 ? 285 ASP A CB  1 
ATOM   1672 C CG  . ASP A 1 285 ? 225.188 270.949 380.550 1.00 24.51 ? 285 ASP A CG  1 
ATOM   1673 O OD1 . ASP A 1 285 ? 224.794 269.770 380.640 1.00 30.93 ? 285 ASP A OD1 1 
ATOM   1674 O OD2 . ASP A 1 285 ? 226.396 271.258 380.500 1.00 30.69 ? 285 ASP A OD2 1 
ATOM   1675 N N   . TYR A 1 286 ? 221.039 272.693 380.249 1.00 19.82 ? 286 TYR A N   1 
ATOM   1676 C CA  . TYR A 1 286 ? 219.976 273.658 380.473 1.00 23.22 ? 286 TYR A CA  1 
ATOM   1677 C C   . TYR A 1 286 ? 219.739 273.800 381.968 1.00 20.81 ? 286 TYR A C   1 
ATOM   1678 O O   . TYR A 1 286 ? 219.892 272.847 382.733 1.00 26.79 ? 286 TYR A O   1 
ATOM   1679 C CB  . TYR A 1 286 ? 218.679 273.241 379.765 1.00 22.53 ? 286 TYR A CB  1 
ATOM   1680 C CG  . TYR A 1 286 ? 218.367 271.768 379.860 1.00 17.94 ? 286 TYR A CG  1 
ATOM   1681 C CD1 . TYR A 1 286 ? 218.011 271.188 381.070 1.00 22.72 ? 286 TYR A CD1 1 
ATOM   1682 C CD2 . TYR A 1 286 ? 218.416 270.958 378.738 1.00 22.21 ? 286 TYR A CD2 1 
ATOM   1683 C CE1 . TYR A 1 286 ? 217.722 269.843 381.157 1.00 21.64 ? 286 TYR A CE1 1 
ATOM   1684 C CE2 . TYR A 1 286 ? 218.125 269.613 378.817 1.00 21.84 ? 286 TYR A CE2 1 
ATOM   1685 C CZ  . TYR A 1 286 ? 217.779 269.061 380.028 1.00 19.00 ? 286 TYR A CZ  1 
ATOM   1686 O OH  . TYR A 1 286 ? 217.497 267.722 380.111 1.00 23.70 ? 286 TYR A OH  1 
ATOM   1687 N N   . LYS A 1 287 ? 219.384 275.014 382.384 1.00 29.90 ? 287 LYS A N   1 
ATOM   1688 C CA  . LYS A 1 287 ? 219.145 275.279 383.797 1.00 29.70 ? 287 LYS A CA  1 
ATOM   1689 C C   . LYS A 1 287 ? 217.810 275.967 384.048 1.00 31.57 ? 287 LYS A C   1 
ATOM   1690 O O   . LYS A 1 287 ? 217.122 275.649 385.022 1.00 35.30 ? 287 LYS A O   1 
ATOM   1691 C CB  . LYS A 1 287 ? 220.281 276.135 384.359 1.00 31.59 ? 287 LYS A CB  1 
ATOM   1692 C CG  . LYS A 1 287 ? 220.164 276.437 385.841 1.00 33.26 ? 287 LYS A CG  1 
ATOM   1693 C CD  . LYS A 1 287 ? 221.225 277.425 386.290 1.00 35.68 ? 287 LYS A CD  1 
ATOM   1694 C CE  . LYS A 1 287 ? 221.064 277.781 387.756 1.00 36.11 ? 287 LYS A CE  1 
ATOM   1695 N NZ  . LYS A 1 287 ? 221.043 276.576 388.625 1.00 36.51 ? 287 LYS A NZ  1 
ATOM   1696 N N   . ASP A 1 288 ? 217.428 276.901 383.181 1.00 32.98 ? 288 ASP A N   1 
ATOM   1697 C CA  . ASP A 1 288 ? 216.303 277.787 383.437 1.00 27.77 ? 288 ASP A CA  1 
ATOM   1698 C C   . ASP A 1 288 ? 215.452 277.929 382.184 1.00 32.16 ? 288 ASP A C   1 
ATOM   1699 O O   . ASP A 1 288 ? 215.856 277.554 381.081 1.00 33.89 ? 288 ASP A O   1 
ATOM   1700 C CB  . ASP A 1 288 ? 216.776 279.171 383.902 1.00 31.07 ? 288 ASP A CB  1 
ATOM   1701 C CG  . ASP A 1 288 ? 217.425 279.137 385.269 1.00 37.89 ? 288 ASP A CG  1 
ATOM   1702 O OD1 . ASP A 1 288 ? 217.027 278.296 386.100 1.00 36.75 ? 288 ASP A OD1 1 
ATOM   1703 O OD2 . ASP A 1 288 ? 218.335 279.956 385.514 1.00 39.02 ? 288 ASP A OD2 1 
ATOM   1704 N N   . GLY A 1 289 ? 214.260 278.486 382.374 1.00 28.55 ? 289 GLY A N   1 
ATOM   1705 C CA  . GLY A 1 289 ? 213.343 278.700 381.268 1.00 28.16 ? 289 GLY A CA  1 
ATOM   1706 C C   . GLY A 1 289 ? 212.926 277.419 380.583 1.00 30.51 ? 289 GLY A C   1 
ATOM   1707 O O   . GLY A 1 289 ? 212.832 277.378 379.350 1.00 34.97 ? 289 GLY A O   1 
ATOM   1708 N N   . LEU A 1 290 ? 212.659 276.371 381.358 1.00 26.75 ? 290 LEU A N   1 
ATOM   1709 C CA  . LEU A 1 290 ? 212.378 275.060 380.793 1.00 29.09 ? 290 LEU A CA  1 
ATOM   1710 C C   . LEU A 1 290 ? 210.931 274.897 380.350 1.00 33.63 ? 290 LEU A C   1 
ATOM   1711 O O   . LEU A 1 290 ? 210.592 273.855 379.780 1.00 34.43 ? 290 LEU A O   1 
ATOM   1712 C CB  . LEU A 1 290 ? 212.733 273.973 381.809 1.00 26.32 ? 290 LEU A CB  1 
ATOM   1713 C CG  . LEU A 1 290 ? 214.133 274.087 382.419 1.00 30.91 ? 290 LEU A CG  1 
ATOM   1714 C CD1 . LEU A 1 290 ? 214.401 272.917 383.342 1.00 25.79 ? 290 LEU A CD1 1 
ATOM   1715 C CD2 . LEU A 1 290 ? 215.202 274.178 381.340 1.00 27.47 ? 290 LEU A CD2 1 
ATOM   1716 N N   . ALA A 1 291 ? 210.081 275.896 380.577 1.00 36.58 ? 291 ALA A N   1 
ATOM   1717 C CA  . ALA A 1 291 ? 208.683 275.845 380.171 1.00 29.10 ? 291 ALA A CA  1 
ATOM   1718 C C   . ALA A 1 291 ? 208.424 276.866 379.070 1.00 29.04 ? 291 ALA A C   1 
ATOM   1719 O O   . ALA A 1 291 ? 207.766 277.884 379.311 1.00 36.23 ? 291 ALA A O   1 
ATOM   1720 C CB  . ALA A 1 291 ? 207.773 276.108 381.371 1.00 30.62 ? 291 ALA A CB  1 
ATOM   1721 N N   . PRO A 1 292 ? 208.911 276.629 377.850 1.00 29.90 ? 292 PRO A N   1 
ATOM   1722 C CA  . PRO A 1 292 ? 208.773 277.657 376.806 1.00 29.55 ? 292 PRO A CA  1 
ATOM   1723 C C   . PRO A 1 292 ? 207.355 277.842 376.288 1.00 31.25 ? 292 PRO A C   1 
ATOM   1724 O O   . PRO A 1 292 ? 206.929 278.983 376.075 1.00 32.41 ? 292 PRO A O   1 
ATOM   1725 C CB  . PRO A 1 292 ? 209.714 277.151 375.705 1.00 28.43 ? 292 PRO A CB  1 
ATOM   1726 C CG  . PRO A 1 292 ? 209.791 275.684 375.914 1.00 29.77 ? 292 PRO A CG  1 
ATOM   1727 C CD  . PRO A 1 292 ? 209.699 275.474 377.389 1.00 29.09 ? 292 PRO A CD  1 
ATOM   1728 N N   . LEU A 1 293 ? 206.609 276.758 376.074 1.00 31.03 ? 293 LEU A N   1 
ATOM   1729 C CA  . LEU A 1 293 ? 205.351 276.868 375.348 1.00 33.02 ? 293 LEU A CA  1 
ATOM   1730 C C   . LEU A 1 293 ? 204.283 277.554 376.200 1.00 34.54 ? 293 LEU A C   1 
ATOM   1731 O O   . LEU A 1 293 ? 204.241 277.363 377.417 1.00 31.02 ? 293 LEU A O   1 
ATOM   1732 C CB  . LEU A 1 293 ? 204.862 275.487 374.916 1.00 33.58 ? 293 LEU A CB  1 
ATOM   1733 C CG  . LEU A 1 293 ? 205.776 274.768 373.922 1.00 33.27 ? 293 LEU A CG  1 
ATOM   1734 C CD1 . LEU A 1 293 ? 205.301 273.358 373.683 1.00 36.27 ? 293 LEU A CD1 1 
ATOM   1735 C CD2 . LEU A 1 293 ? 205.858 275.523 372.610 1.00 37.82 ? 293 LEU A CD2 1 
ATOM   1736 N N   . PRO A 1 294 ? 203.409 278.352 375.589 1.00 39.54 ? 294 PRO A N   1 
ATOM   1737 C CA  . PRO A 1 294 ? 202.312 278.973 376.336 1.00 37.10 ? 294 PRO A CA  1 
ATOM   1738 C C   . PRO A 1 294 ? 201.102 278.052 376.434 1.00 38.39 ? 294 PRO A C   1 
ATOM   1739 O O   . PRO A 1 294 ? 201.101 276.918 375.957 1.00 36.17 ? 294 PRO A O   1 
ATOM   1740 C CB  . PRO A 1 294 ? 201.991 280.217 375.505 1.00 32.93 ? 294 PRO A CB  1 
ATOM   1741 C CG  . PRO A 1 294 ? 202.303 279.806 374.118 1.00 34.34 ? 294 PRO A CG  1 
ATOM   1742 C CD  . PRO A 1 294 ? 203.467 278.850 374.203 1.00 34.88 ? 294 PRO A CD  1 
ATOM   1743 N N   . GLU A 1 295 ? 200.054 278.575 377.066 1.00 41.90 ? 295 GLU A N   1 
ATOM   1744 C CA  . GLU A 1 295 ? 198.801 277.846 377.207 1.00 41.79 ? 295 GLU A CA  1 
ATOM   1745 C C   . GLU A 1 295 ? 197.866 278.177 376.049 1.00 41.43 ? 295 GLU A C   1 
ATOM   1746 O O   . GLU A 1 295 ? 197.763 279.335 375.634 1.00 41.74 ? 295 GLU A O   1 
ATOM   1747 C CB  . GLU A 1 295 ? 198.139 278.186 378.541 1.00 39.32 ? 295 GLU A CB  1 
ATOM   1748 C CG  . GLU A 1 295 ? 196.774 277.553 378.732 1.00 40.15 ? 295 GLU A CG  1 
ATOM   1749 C CD  . GLU A 1 295 ? 196.316 277.565 380.176 1.00 46.10 ? 295 GLU A CD  1 
ATOM   1750 O OE1 . GLU A 1 295 ? 197.140 277.862 381.065 1.00 46.44 ? 295 GLU A OE1 1 
ATOM   1751 O OE2 . GLU A 1 295 ? 195.129 277.269 380.424 1.00 48.35 ? 295 GLU A OE2 1 
ATOM   1752 N N   . LYS A 1 296 ? 197.186 277.156 375.530 1.00 42.89 ? 296 LYS A N   1 
ATOM   1753 C CA  . LYS A 1 296 ? 196.276 277.320 374.401 1.00 39.82 ? 296 LYS A CA  1 
ATOM   1754 C C   . LYS A 1 296 ? 195.250 276.198 374.444 1.00 39.27 ? 296 LYS A C   1 
ATOM   1755 O O   . LYS A 1 296 ? 195.619 275.021 374.430 1.00 40.52 ? 296 LYS A O   1 
ATOM   1756 C CB  . LYS A 1 296 ? 197.042 277.305 373.076 1.00 39.63 ? 296 LYS A CB  1 
ATOM   1757 C CG  . LYS A 1 296 ? 196.190 277.545 371.844 1.00 39.99 ? 296 LYS A CG  1 
ATOM   1758 C CD  . LYS A 1 296 ? 195.684 278.968 371.778 1.00 40.21 ? 296 LYS A CD  1 
ATOM   1759 C CE  . LYS A 1 296 ? 194.875 279.207 370.522 1.00 39.74 ? 296 LYS A CE  1 
ATOM   1760 N NZ  . LYS A 1 296 ? 194.352 280.595 370.451 1.00 41.08 ? 296 LYS A NZ  1 
ATOM   1761 N N   . GLY A 1 297 ? 193.970 276.560 374.486 1.00 41.83 ? 297 GLY A N   1 
ATOM   1762 C CA  . GLY A 1 297 ? 192.929 275.552 374.570 1.00 41.41 ? 297 GLY A CA  1 
ATOM   1763 C C   . GLY A 1 297 ? 192.915 274.642 373.357 1.00 40.32 ? 297 GLY A C   1 
ATOM   1764 O O   . GLY A 1 297 ? 193.192 275.058 372.232 1.00 41.11 ? 297 GLY A O   1 
ATOM   1765 N N   . LEU A 1 298 ? 192.581 273.373 373.603 1.00 38.58 ? 298 LEU A N   1 
ATOM   1766 C CA  . LEU A 1 298 ? 192.588 272.375 372.538 1.00 40.84 ? 298 LEU A CA  1 
ATOM   1767 C C   . LEU A 1 298 ? 191.542 272.684 371.471 1.00 38.68 ? 298 LEU A C   1 
ATOM   1768 O O   . LEU A 1 298 ? 191.806 272.527 370.274 1.00 37.00 ? 298 LEU A O   1 
ATOM   1769 C CB  . LEU A 1 298 ? 192.355 270.985 373.133 1.00 36.46 ? 298 LEU A CB  1 
ATOM   1770 C CG  . LEU A 1 298 ? 192.258 269.799 372.170 1.00 34.84 ? 298 LEU A CG  1 
ATOM   1771 C CD1 . LEU A 1 298 ? 193.527 269.640 371.359 1.00 35.44 ? 298 LEU A CD1 1 
ATOM   1772 C CD2 . LEU A 1 298 ? 191.961 268.526 372.942 1.00 37.11 ? 298 LEU A CD2 1 
ATOM   1773 N N   . THR A 1 299 ? 190.355 273.120 371.882 1.00 41.04 ? 299 THR A N   1 
ATOM   1774 C CA  . THR A 1 299 ? 189.252 273.409 370.971 1.00 42.73 ? 299 THR A CA  1 
ATOM   1775 C C   . THR A 1 299 ? 189.076 274.911 370.769 1.00 39.81 ? 299 THR A C   1 
ATOM   1776 O O   . THR A 1 299 ? 187.958 275.410 370.643 1.00 42.35 ? 299 THR A O   1 
ATOM   1777 C CB  . THR A 1 299 ? 187.954 272.785 371.479 1.00 40.30 ? 299 THR A CB  1 
ATOM   1778 O OG1 . THR A 1 299 ? 187.806 273.050 372.878 1.00 41.56 ? 299 THR A OG1 1 
ATOM   1779 C CG2 . THR A 1 299 ? 187.947 271.281 371.240 1.00 36.81 ? 299 THR A CG2 1 
ATOM   1780 N N   . THR A 1 300 ? 190.184 275.646 370.737 1.00 40.10 ? 300 THR A N   1 
ATOM   1781 C CA  . THR A 1 300 ? 190.172 277.083 370.501 1.00 42.87 ? 300 THR A CA  1 
ATOM   1782 C C   . THR A 1 300 ? 191.112 277.395 369.348 1.00 41.77 ? 300 THR A C   1 
ATOM   1783 O O   . THR A 1 300 ? 192.287 277.021 369.386 1.00 44.72 ? 300 THR A O   1 
ATOM   1784 C CB  . THR A 1 300 ? 190.594 277.858 371.754 1.00 45.23 ? 300 THR A CB  1 
ATOM   1785 O OG1 . THR A 1 300 ? 189.702 277.551 372.831 1.00 47.91 ? 300 THR A OG1 1 
ATOM   1786 C CG2 . THR A 1 300 ? 190.570 279.356 371.496 1.00 42.69 ? 300 THR A CG2 1 
ATOM   1787 N N   . TYR A 1 301 ? 190.595 278.073 368.329 1.00 43.13 ? 301 TYR A N   1 
ATOM   1788 C CA  . TYR A 1 301 ? 191.391 278.411 367.154 1.00 43.68 ? 301 TYR A CA  1 
ATOM   1789 C C   . TYR A 1 301 ? 192.409 279.495 367.482 1.00 46.24 ? 301 TYR A C   1 
ATOM   1790 O O   . TYR A 1 301 ? 193.420 279.638 366.799 1.00 47.55 ? 301 TYR A O   1 
ATOM   1791 C CB  . TYR A 1 301 ? 190.492 278.877 366.008 1.00 43.71 ? 301 TYR A CB  1 
ATOM   1792 C CG  . TYR A 1 301 ? 189.545 277.822 365.486 1.00 42.56 ? 301 TYR A CG  1 
ATOM   1793 C CD1 . TYR A 1 301 ? 189.969 276.873 364.569 1.00 39.43 ? 301 TYR A CD1 1 
ATOM   1794 C CD2 . TYR A 1 301 ? 188.221 277.786 365.898 1.00 41.65 ? 301 TYR A CD2 1 
ATOM   1795 C CE1 . TYR A 1 301 ? 189.105 275.914 364.086 1.00 42.82 ? 301 TYR A CE1 1 
ATOM   1796 C CE2 . TYR A 1 301 ? 187.351 276.831 365.419 1.00 42.27 ? 301 TYR A CE2 1 
ATOM   1797 C CZ  . TYR A 1 301 ? 187.797 275.901 364.511 1.00 43.63 ? 301 TYR A CZ  1 
ATOM   1798 O OH  . TYR A 1 301 ? 186.931 274.947 364.031 1.00 44.01 ? 301 TYR A OH  1 
ATOM   1799 O OXT . TYR A 1 301 ? 192.242 280.255 368.434 1.00 47.50 ? 301 TYR A OXT 1 
ATOM   1800 N N   . THR B 2 86  ? 220.234 238.242 357.868 1.00 32.93 ? 86  THR B N   1 
ATOM   1801 C CA  . THR B 2 86  ? 221.239 237.436 358.551 1.00 37.21 ? 86  THR B CA  1 
ATOM   1802 C C   . THR B 2 86  ? 222.616 238.093 358.479 1.00 37.50 ? 86  THR B C   1 
ATOM   1803 O O   . THR B 2 86  ? 223.071 238.485 357.407 1.00 39.14 ? 86  THR B O   1 
ATOM   1804 C CB  . THR B 2 86  ? 221.325 236.018 357.951 1.00 38.95 ? 86  THR B CB  1 
ATOM   1805 O OG1 . THR B 2 86  ? 220.101 235.316 358.195 1.00 39.38 ? 86  THR B OG1 1 
ATOM   1806 C CG2 . THR B 2 86  ? 222.484 235.242 358.560 1.00 34.23 ? 86  THR B CG2 1 
ATOM   1807 N N   . LEU B 2 87  ? 223.269 238.213 359.633 1.00 32.87 ? 87  LEU B N   1 
ATOM   1808 C CA  . LEU B 2 87  ? 224.627 238.746 359.735 1.00 32.36 ? 87  LEU B CA  1 
ATOM   1809 C C   . LEU B 2 87  ? 225.426 237.769 360.589 1.00 32.01 ? 87  LEU B C   1 
ATOM   1810 O O   . LEU B 2 87  ? 225.201 237.666 361.798 1.00 33.10 ? 87  LEU B O   1 
ATOM   1811 C CB  . LEU B 2 87  ? 224.634 240.149 360.339 1.00 29.38 ? 87  LEU B CB  1 
ATOM   1812 C CG  . LEU B 2 87  ? 223.663 241.158 359.723 1.00 31.78 ? 87  LEU B CG  1 
ATOM   1813 C CD1 . LEU B 2 87  ? 223.653 242.446 360.527 1.00 28.88 ? 87  LEU B CD1 1 
ATOM   1814 C CD2 . LEU B 2 87  ? 224.007 241.445 358.267 1.00 32.18 ? 87  LEU B CD2 1 
ATOM   1815 N N   . GLY B 2 88  ? 226.358 237.055 359.961 1.00 35.05 ? 88  GLY B N   1 
ATOM   1816 C CA  . GLY B 2 88  ? 227.099 236.029 360.670 1.00 35.42 ? 88  GLY B CA  1 
ATOM   1817 C C   . GLY B 2 88  ? 226.211 234.849 361.027 1.00 34.48 ? 88  GLY B C   1 
ATOM   1818 O O   . GLY B 2 88  ? 225.338 234.440 360.259 1.00 36.43 ? 88  GLY B O   1 
ATOM   1819 N N   . ASN B 2 89  ? 226.441 234.297 362.215 1.00 34.08 ? 89  ASN B N   1 
ATOM   1820 C CA  . ASN B 2 89  ? 225.634 233.192 362.716 1.00 33.29 ? 89  ASN B CA  1 
ATOM   1821 C C   . ASN B 2 89  ? 224.334 233.661 363.361 1.00 32.36 ? 89  ASN B C   1 
ATOM   1822 O O   . ASN B 2 89  ? 223.542 232.825 363.808 1.00 33.98 ? 89  ASN B O   1 
ATOM   1823 C CB  . ASN B 2 89  ? 226.444 232.355 363.714 1.00 28.10 ? 89  ASN B CB  1 
ATOM   1824 C CG  . ASN B 2 89  ? 226.902 233.155 364.920 1.00 34.46 ? 89  ASN B CG  1 
ATOM   1825 O OD1 . ASN B 2 89  ? 226.380 234.234 365.203 1.00 32.68 ? 89  ASN B OD1 1 
ATOM   1826 N ND2 . ASN B 2 89  ? 227.884 232.624 365.640 1.00 28.17 ? 89  ASN B ND2 1 
ATOM   1827 N N   . SER B 2 90  ? 224.097 234.968 363.411 1.00 30.88 ? 90  SER B N   1 
ATOM   1828 C CA  . SER B 2 90  ? 222.885 235.537 363.978 1.00 34.10 ? 90  SER B CA  1 
ATOM   1829 C C   . SER B 2 90  ? 221.875 235.786 362.867 1.00 36.08 ? 90  SER B C   1 
ATOM   1830 O O   . SER B 2 90  ? 222.237 236.247 361.780 1.00 36.84 ? 90  SER B O   1 
ATOM   1831 C CB  . SER B 2 90  ? 223.181 236.851 364.705 1.00 31.94 ? 90  SER B CB  1 
ATOM   1832 O OG  . SER B 2 90  ? 224.354 236.763 365.493 1.00 28.27 ? 90  SER B OG  1 
ATOM   1833 N N   . THR B 2 91  ? 220.609 235.479 363.140 1.00 34.16 ? 91  THR B N   1 
ATOM   1834 C CA  . THR B 2 91  ? 219.550 235.670 362.159 1.00 38.15 ? 91  THR B CA  1 
ATOM   1835 C C   . THR B 2 91  ? 218.337 236.300 362.825 1.00 42.16 ? 91  THR B C   1 
ATOM   1836 O O   . THR B 2 91  ? 217.862 235.805 363.851 1.00 37.03 ? 91  THR B O   1 
ATOM   1837 C CB  . THR B 2 91  ? 219.157 234.342 361.502 1.00 36.99 ? 91  THR B CB  1 
ATOM   1838 O OG1 . THR B 2 91  ? 220.278 233.809 360.787 1.00 35.68 ? 91  THR B OG1 1 
ATOM   1839 C CG2 . THR B 2 91  ? 217.999 234.545 360.540 1.00 37.74 ? 91  THR B CG2 1 
ATOM   1840 N N   . ILE B 2 92  ? 217.843 237.382 362.224 1.00 42.60 ? 92  ILE B N   1 
ATOM   1841 C CA  . ILE B 2 92  ? 216.595 238.037 362.618 1.00 40.43 ? 92  ILE B CA  1 
ATOM   1842 C C   . ILE B 2 92  ? 216.375 237.995 364.125 1.00 40.21 ? 92  ILE B C   1 
ATOM   1843 O O   . ILE B 2 92  ? 215.459 238.627 364.646 1.00 40.62 ? 92  ILE B O   1 
ATOM   1844 C CB  . ILE B 2 92  ? 215.391 237.408 361.874 1.00 39.94 ? 92  ILE B CB  1 
ATOM   1845 C CG1 . ILE B 2 92  ? 214.144 238.281 362.035 1.00 41.38 ? 92  ILE B CG1 1 
ATOM   1846 C CG2 . ILE B 2 92  ? 215.106 236.003 362.384 1.00 39.92 ? 92  ILE B CG2 1 
ATOM   1847 C CD1 . ILE B 2 92  ? 212.994 237.874 361.132 1.00 41.47 ? 92  ILE B CD1 1 
ATOM   1848 N N   . ASN B 2 99  ? 208.603 249.571 358.927 1.00 28.03 ? 99  ASN B N   1 
ATOM   1849 C CA  . ASN B 2 99  ? 209.556 248.556 358.497 1.00 25.43 ? 99  ASN B CA  1 
ATOM   1850 C C   . ASN B 2 99  ? 210.982 249.059 358.725 1.00 29.54 ? 99  ASN B C   1 
ATOM   1851 O O   . ASN B 2 99  ? 211.212 249.914 359.580 1.00 30.45 ? 99  ASN B O   1 
ATOM   1852 C CB  . ASN B 2 99  ? 209.331 248.201 357.023 1.00 24.05 ? 99  ASN B CB  1 
ATOM   1853 C CG  . ASN B 2 99  ? 209.794 246.797 356.681 1.00 29.17 ? 99  ASN B CG  1 
ATOM   1854 O OD1 . ASN B 2 99  ? 209.874 245.926 357.547 1.00 30.46 ? 99  ASN B OD1 1 
ATOM   1855 N ND2 . ASN B 2 99  ? 210.109 246.572 355.410 1.00 30.57 ? 99  ASN B ND2 1 
ATOM   1856 N N   . SER B 2 100 ? 211.935 248.520 357.971 1.00 20.43 ? 100 SER B N   1 
ATOM   1857 C CA  . SER B 2 100 ? 213.317 248.958 358.084 1.00 18.46 ? 100 SER B CA  1 
ATOM   1858 C C   . SER B 2 100 ? 213.466 250.388 357.581 1.00 17.47 ? 100 SER B C   1 
ATOM   1859 O O   . SER B 2 100 ? 212.788 250.809 356.640 1.00 22.75 ? 100 SER B O   1 
ATOM   1860 C CB  . SER B 2 100 ? 214.231 248.025 357.293 1.00 24.96 ? 100 SER B CB  1 
ATOM   1861 O OG  . SER B 2 100 ? 215.575 248.470 357.331 1.00 25.91 ? 100 SER B OG  1 
ATOM   1862 N N   . VAL B 2 101 ? 214.354 251.141 358.222 1.00 18.19 ? 101 VAL B N   1 
ATOM   1863 C CA  . VAL B 2 101 ? 214.675 252.503 357.814 1.00 17.34 ? 101 VAL B CA  1 
ATOM   1864 C C   . VAL B 2 101 ? 216.186 252.622 357.716 1.00 15.69 ? 101 VAL B C   1 
ATOM   1865 O O   . VAL B 2 101 ? 216.897 252.352 358.690 1.00 18.97 ? 101 VAL B O   1 
ATOM   1866 C CB  . VAL B 2 101 ? 214.111 253.548 358.792 1.00 14.11 ? 101 VAL B CB  1 
ATOM   1867 C CG1 . VAL B 2 101 ? 214.727 254.914 358.530 1.00 15.04 ? 101 VAL B CG1 1 
ATOM   1868 C CG2 . VAL B 2 101 ? 212.607 253.617 358.668 1.00 19.26 ? 101 VAL B CG2 1 
ATOM   1869 N N   . VAL B 2 102 ? 216.673 253.022 356.548 1.00 16.60 ? 102 VAL B N   1 
ATOM   1870 C CA  . VAL B 2 102 ? 218.088 253.303 356.347 1.00 13.83 ? 102 VAL B CA  1 
ATOM   1871 C C   . VAL B 2 102 ? 218.299 254.784 356.635 1.00 14.14 ? 102 VAL B C   1 
ATOM   1872 O O   . VAL B 2 102 ? 217.767 255.644 355.929 1.00 19.22 ? 102 VAL B O   1 
ATOM   1873 C CB  . VAL B 2 102 ? 218.537 252.938 354.928 1.00 16.86 ? 102 VAL B CB  1 
ATOM   1874 C CG1 . VAL B 2 102 ? 220.025 253.187 354.759 1.00 17.63 ? 102 VAL B CG1 1 
ATOM   1875 C CG2 . VAL B 2 102 ? 218.195 251.490 354.628 1.00 16.71 ? 102 VAL B CG2 1 
ATOM   1876 N N   . ALA B 2 103 ? 219.067 255.083 357.679 1.00 12.34 ? 103 ALA B N   1 
ATOM   1877 C CA  . ALA B 2 103 ? 219.280 256.467 358.078 1.00 12.08 ? 103 ALA B CA  1 
ATOM   1878 C C   . ALA B 2 103 ? 219.904 257.263 356.941 1.00 14.25 ? 103 ALA B C   1 
ATOM   1879 O O   . ALA B 2 103 ? 220.930 256.871 356.379 1.00 18.85 ? 103 ALA B O   1 
ATOM   1880 C CB  . ALA B 2 103 ? 220.172 256.527 359.316 1.00 12.74 ? 103 ALA B CB  1 
ATOM   1881 N N   . TYR B 2 104 ? 219.274 258.387 356.603 1.00 9.87  ? 104 TYR B N   1 
ATOM   1882 C CA  . TYR B 2 104 ? 219.730 259.285 355.545 1.00 15.58 ? 104 TYR B CA  1 
ATOM   1883 C C   . TYR B 2 104 ? 219.870 258.577 354.200 1.00 18.74 ? 104 TYR B C   1 
ATOM   1884 O O   . TYR B 2 104 ? 220.556 259.076 353.304 1.00 19.51 ? 104 TYR B O   1 
ATOM   1885 C CB  . TYR B 2 104 ? 221.056 259.955 355.924 1.00 10.85 ? 104 TYR B CB  1 
ATOM   1886 C CG  . TYR B 2 104 ? 221.047 260.611 357.285 1.00 10.69 ? 104 TYR B CG  1 
ATOM   1887 C CD1 . TYR B 2 104 ? 220.215 261.688 357.555 1.00 9.70  ? 104 TYR B CD1 1 
ATOM   1888 C CD2 . TYR B 2 104 ? 221.877 260.159 358.300 1.00 10.42 ? 104 TYR B CD2 1 
ATOM   1889 C CE1 . TYR B 2 104 ? 220.207 262.288 358.796 1.00 8.22  ? 104 TYR B CE1 1 
ATOM   1890 C CE2 . TYR B 2 104 ? 221.877 260.754 359.542 1.00 4.43  ? 104 TYR B CE2 1 
ATOM   1891 C CZ  . TYR B 2 104 ? 221.040 261.816 359.786 1.00 13.80 ? 104 TYR B CZ  1 
ATOM   1892 O OH  . TYR B 2 104 ? 221.035 262.414 361.021 1.00 15.76 ? 104 TYR B OH  1 
ATOM   1893 N N   . GLY B 2 105 ? 219.230 257.422 354.038 1.00 21.38 ? 105 GLY B N   1 
ATOM   1894 C CA  . GLY B 2 105 ? 219.306 256.695 352.787 1.00 16.49 ? 105 GLY B CA  1 
ATOM   1895 C C   . GLY B 2 105 ? 220.686 256.197 352.428 1.00 20.58 ? 105 GLY B C   1 
ATOM   1896 O O   . GLY B 2 105 ? 220.952 255.945 351.252 1.00 22.35 ? 105 GLY B O   1 
ATOM   1897 N N   . ARG B 2 106 ? 221.573 256.042 353.408 1.00 23.72 ? 106 ARG B N   1 
ATOM   1898 C CA  . ARG B 2 106 ? 222.962 255.658 353.169 1.00 17.16 ? 106 ARG B CA  1 
ATOM   1899 C C   . ARG B 2 106 ? 223.246 254.353 353.900 1.00 20.66 ? 106 ARG B C   1 
ATOM   1900 O O   . ARG B 2 106 ? 223.239 254.311 355.134 1.00 27.17 ? 106 ARG B O   1 
ATOM   1901 C CB  . ARG B 2 106 ? 223.914 256.763 353.622 1.00 19.00 ? 106 ARG B CB  1 
ATOM   1902 C CG  . ARG B 2 106 ? 224.040 257.905 352.627 1.00 22.17 ? 106 ARG B CG  1 
ATOM   1903 C CD  . ARG B 2 106 ? 225.091 257.613 351.568 1.00 20.58 ? 106 ARG B CD  1 
ATOM   1904 N NE  . ARG B 2 106 ? 226.436 257.605 352.132 1.00 23.39 ? 106 ARG B NE  1 
ATOM   1905 C CZ  . ARG B 2 106 ? 227.171 258.689 352.345 1.00 19.34 ? 106 ARG B CZ  1 
ATOM   1906 N NH1 . ARG B 2 106 ? 226.728 259.898 352.040 1.00 19.02 ? 106 ARG B NH1 1 
ATOM   1907 N NH2 . ARG B 2 106 ? 228.379 258.558 352.884 1.00 19.40 ? 106 ARG B NH2 1 
ATOM   1908 N N   . TRP B 2 107 ? 223.489 253.294 353.136 1.00 21.44 ? 107 TRP B N   1 
ATOM   1909 C CA  . TRP B 2 107 ? 223.842 252.015 353.722 1.00 22.06 ? 107 TRP B CA  1 
ATOM   1910 C C   . TRP B 2 107 ? 225.257 252.082 354.299 1.00 21.90 ? 107 TRP B C   1 
ATOM   1911 O O   . TRP B 2 107 ? 226.107 252.814 353.787 1.00 24.39 ? 107 TRP B O   1 
ATOM   1912 C CB  . TRP B 2 107 ? 223.752 250.915 352.668 1.00 20.15 ? 107 TRP B CB  1 
ATOM   1913 C CG  . TRP B 2 107 ? 223.499 249.551 353.223 1.00 24.47 ? 107 TRP B CG  1 
ATOM   1914 C CD1 . TRP B 2 107 ? 224.427 248.581 353.476 1.00 24.02 ? 107 TRP B CD1 1 
ATOM   1915 C CD2 . TRP B 2 107 ? 222.230 248.997 353.590 1.00 23.50 ? 107 TRP B CD2 1 
ATOM   1916 N NE1 . TRP B 2 107 ? 223.813 247.461 353.981 1.00 26.01 ? 107 TRP B NE1 1 
ATOM   1917 C CE2 . TRP B 2 107 ? 222.465 247.690 354.059 1.00 21.52 ? 107 TRP B CE2 1 
ATOM   1918 C CE3 . TRP B 2 107 ? 220.919 249.479 353.566 1.00 19.93 ? 107 TRP B CE3 1 
ATOM   1919 C CZ2 . TRP B 2 107 ? 221.437 246.862 354.504 1.00 22.44 ? 107 TRP B CZ2 1 
ATOM   1920 C CZ3 . TRP B 2 107 ? 219.901 248.655 354.006 1.00 20.44 ? 107 TRP B CZ3 1 
ATOM   1921 C CH2 . TRP B 2 107 ? 220.166 247.362 354.469 1.00 20.56 ? 107 TRP B CH2 1 
ATOM   1922 N N   . PRO B 2 108 ? 225.536 251.342 355.372 1.00 22.14 ? 108 PRO B N   1 
ATOM   1923 C CA  . PRO B 2 108 ? 226.905 251.310 355.897 1.00 20.31 ? 108 PRO B CA  1 
ATOM   1924 C C   . PRO B 2 108 ? 227.886 250.811 354.846 1.00 22.92 ? 108 PRO B C   1 
ATOM   1925 O O   . PRO B 2 108 ? 227.551 249.985 353.996 1.00 28.28 ? 108 PRO B O   1 
ATOM   1926 C CB  . PRO B 2 108 ? 226.808 250.348 357.085 1.00 21.57 ? 108 PRO B CB  1 
ATOM   1927 C CG  . PRO B 2 108 ? 225.396 250.439 357.519 1.00 22.29 ? 108 PRO B CG  1 
ATOM   1928 C CD  . PRO B 2 108 ? 224.594 250.655 356.272 1.00 21.05 ? 108 PRO B CD  1 
ATOM   1929 N N   . GLU B 2 109 ? 229.107 251.338 354.902 1.00 26.53 ? 109 GLU B N   1 
ATOM   1930 C CA  . GLU B 2 109 ? 230.137 250.987 353.936 1.00 27.33 ? 109 GLU B CA  1 
ATOM   1931 C C   . GLU B 2 109 ? 231.505 251.129 354.585 1.00 28.47 ? 109 GLU B C   1 
ATOM   1932 O O   . GLU B 2 109 ? 231.666 251.802 355.606 1.00 27.13 ? 109 GLU B O   1 
ATOM   1933 C CB  . GLU B 2 109 ? 230.049 251.867 352.682 1.00 26.72 ? 109 GLU B CB  1 
ATOM   1934 C CG  . GLU B 2 109 ? 230.187 253.357 352.961 1.00 26.51 ? 109 GLU B CG  1 
ATOM   1935 C CD  . GLU B 2 109 ? 230.098 254.199 351.702 1.00 34.47 ? 109 GLU B CD  1 
ATOM   1936 O OE1 . GLU B 2 109 ? 229.783 253.641 350.630 1.00 34.76 ? 109 GLU B OE1 1 
ATOM   1937 O OE2 . GLU B 2 109 ? 230.343 255.421 351.785 1.00 29.39 ? 109 GLU B OE2 1 
ATOM   1938 N N   . TYR B 2 110 ? 232.492 250.478 353.978 1.00 25.17 ? 110 TYR B N   1 
ATOM   1939 C CA  . TYR B 2 110 ? 233.873 250.641 354.401 1.00 25.57 ? 110 TYR B CA  1 
ATOM   1940 C C   . TYR B 2 110 ? 234.444 251.942 353.841 1.00 27.70 ? 110 TYR B C   1 
ATOM   1941 O O   . TYR B 2 110 ? 233.892 252.545 352.917 1.00 24.66 ? 110 TYR B O   1 
ATOM   1942 C CB  . TYR B 2 110 ? 234.722 249.452 353.947 1.00 22.18 ? 110 TYR B CB  1 
ATOM   1943 C CG  . TYR B 2 110 ? 234.345 248.136 354.590 1.00 25.88 ? 110 TYR B CG  1 
ATOM   1944 C CD1 . TYR B 2 110 ? 234.652 247.879 355.916 1.00 26.06 ? 110 TYR B CD1 1 
ATOM   1945 C CD2 . TYR B 2 110 ? 233.694 247.147 353.866 1.00 29.17 ? 110 TYR B CD2 1 
ATOM   1946 C CE1 . TYR B 2 110 ? 234.317 246.681 356.508 1.00 26.09 ? 110 TYR B CE1 1 
ATOM   1947 C CE2 . TYR B 2 110 ? 233.354 245.941 354.451 1.00 27.98 ? 110 TYR B CE2 1 
ATOM   1948 C CZ  . TYR B 2 110 ? 233.668 245.715 355.774 1.00 29.49 ? 110 TYR B CZ  1 
ATOM   1949 O OH  . TYR B 2 110 ? 233.334 244.520 356.366 1.00 28.06 ? 110 TYR B OH  1 
ATOM   1950 N N   . ILE B 2 111 ? 235.563 252.373 354.417 1.00 23.57 ? 111 ILE B N   1 
ATOM   1951 C CA  . ILE B 2 111 ? 236.224 253.600 353.982 1.00 23.85 ? 111 ILE B CA  1 
ATOM   1952 C C   . ILE B 2 111 ? 236.603 253.490 352.509 1.00 24.58 ? 111 ILE B C   1 
ATOM   1953 O O   . ILE B 2 111 ? 236.835 252.395 351.998 1.00 29.42 ? 111 ILE B O   1 
ATOM   1954 C CB  . ILE B 2 111 ? 237.470 253.908 354.839 1.00 23.74 ? 111 ILE B CB  1 
ATOM   1955 C CG1 . ILE B 2 111 ? 237.078 254.088 356.305 1.00 22.05 ? 111 ILE B CG1 1 
ATOM   1956 C CG2 . ILE B 2 111 ? 238.170 255.166 354.329 1.00 22.17 ? 111 ILE B CG2 1 
ATOM   1957 C CD1 . ILE B 2 111 ? 238.254 254.174 357.257 1.00 19.08 ? 111 ILE B CD1 1 
ATOM   1958 N N   . ALA B 2 126 ? 236.291 242.093 364.129 1.00 31.52 ? 126 ALA B N   1 
ATOM   1959 C CA  . ALA B 2 126 ? 236.452 242.531 362.748 1.00 33.94 ? 126 ALA B CA  1 
ATOM   1960 C C   . ALA B 2 126 ? 235.265 242.085 361.899 1.00 31.28 ? 126 ALA B C   1 
ATOM   1961 O O   . ALA B 2 126 ? 234.319 242.843 361.701 1.00 31.11 ? 126 ALA B O   1 
ATOM   1962 C CB  . ALA B 2 126 ? 237.757 241.995 362.172 1.00 27.60 ? 126 ALA B CB  1 
ATOM   1963 N N   . VAL B 2 127 ? 235.315 240.855 361.400 1.00 30.48 ? 127 VAL B N   1 
ATOM   1964 C CA  . VAL B 2 127 ? 234.253 240.286 360.582 1.00 31.01 ? 127 VAL B CA  1 
ATOM   1965 C C   . VAL B 2 127 ? 233.418 239.290 361.379 1.00 29.37 ? 127 VAL B C   1 
ATOM   1966 O O   . VAL B 2 127 ? 232.189 239.327 361.341 1.00 26.50 ? 127 VAL B O   1 
ATOM   1967 C CB  . VAL B 2 127 ? 234.827 239.636 359.302 1.00 31.97 ? 127 VAL B CB  1 
ATOM   1968 C CG1 . VAL B 2 127 ? 235.669 238.407 359.638 1.00 30.26 ? 127 VAL B CG1 1 
ATOM   1969 C CG2 . VAL B 2 127 ? 233.706 239.281 358.336 1.00 30.21 ? 127 VAL B CG2 1 
ATOM   1970 N N   . ALA B 2 128 ? 234.075 238.388 362.109 1.00 31.86 ? 128 ALA B N   1 
ATOM   1971 C CA  . ALA B 2 128 ? 233.358 237.483 362.999 1.00 28.47 ? 128 ALA B CA  1 
ATOM   1972 C C   . ALA B 2 128 ? 232.724 238.247 364.153 1.00 30.67 ? 128 ALA B C   1 
ATOM   1973 O O   . ALA B 2 128 ? 231.566 238.012 364.515 1.00 31.47 ? 128 ALA B O   1 
ATOM   1974 C CB  . ALA B 2 128 ? 234.310 236.410 363.525 1.00 26.74 ? 128 ALA B CB  1 
ATOM   1975 N N   . ALA B 2 129 ? 233.476 239.179 364.741 1.00 22.81 ? 129 ALA B N   1 
ATOM   1976 C CA  . ALA B 2 129 ? 233.006 239.890 365.920 1.00 22.59 ? 129 ALA B CA  1 
ATOM   1977 C C   . ALA B 2 129 ? 231.753 240.709 365.651 1.00 22.37 ? 129 ALA B C   1 
ATOM   1978 O O   . ALA B 2 129 ? 231.000 240.990 366.588 1.00 26.96 ? 129 ALA B O   1 
ATOM   1979 C CB  . ALA B 2 129 ? 234.108 240.806 366.448 1.00 21.46 ? 129 ALA B CB  1 
ATOM   1980 N N   . CYS B 2 130 ? 231.511 241.105 364.403 1.00 23.99 ? 130 CYS B N   1 
ATOM   1981 C CA  . CYS B 2 130 ? 230.429 242.039 364.100 1.00 19.81 ? 130 CYS B CA  1 
ATOM   1982 C C   . CYS B 2 130 ? 229.189 241.250 363.688 1.00 21.22 ? 130 CYS B C   1 
ATOM   1983 O O   . CYS B 2 130 ? 229.030 240.796 362.554 1.00 24.85 ? 130 CYS B O   1 
ATOM   1984 C CB  . CYS B 2 130 ? 230.886 243.050 363.055 1.00 23.73 ? 130 CYS B CB  1 
ATOM   1985 S SG  . CYS B 2 130 ? 231.932 244.313 363.845 1.00 40.71 ? 130 CYS B SG  1 
ATOM   1986 N N   . ARG B 2 131 ? 228.291 241.101 364.661 1.00 27.39 ? 131 ARG B N   1 
ATOM   1987 C CA  . ARG B 2 131 ? 227.111 240.255 364.574 1.00 20.74 ? 131 ARG B CA  1 
ATOM   1988 C C   . ARG B 2 131 ? 226.068 240.816 365.533 1.00 18.24 ? 131 ARG B C   1 
ATOM   1989 O O   . ARG B 2 131 ? 226.331 241.768 366.271 1.00 19.05 ? 131 ARG B O   1 
ATOM   1990 C CB  . ARG B 2 131 ? 227.466 238.802 364.910 1.00 17.18 ? 131 ARG B CB  1 
ATOM   1991 C CG  . ARG B 2 131 ? 228.171 238.661 366.249 1.00 16.99 ? 131 ARG B CG  1 
ATOM   1992 C CD  . ARG B 2 131 ? 228.700 237.264 366.482 1.00 23.31 ? 131 ARG B CD  1 
ATOM   1993 N NE  . ARG B 2 131 ? 227.632 236.276 366.520 1.00 28.66 ? 131 ARG B NE  1 
ATOM   1994 C CZ  . ARG B 2 131 ? 226.798 236.114 367.538 1.00 28.20 ? 131 ARG B CZ  1 
ATOM   1995 N NH1 . ARG B 2 131 ? 226.871 236.871 368.620 1.00 24.94 ? 131 ARG B NH1 1 
ATOM   1996 N NH2 . ARG B 2 131 ? 225.864 235.172 367.465 1.00 26.21 ? 131 ARG B NH2 1 
ATOM   1997 N N   . PHE B 2 132 ? 224.878 240.222 365.535 1.00 15.48 ? 132 PHE B N   1 
ATOM   1998 C CA  . PHE B 2 132 ? 223.800 240.703 366.391 1.00 13.74 ? 132 PHE B CA  1 
ATOM   1999 C C   . PHE B 2 132 ? 224.055 240.325 367.845 1.00 11.97 ? 132 PHE B C   1 
ATOM   2000 O O   . PHE B 2 132 ? 224.368 239.171 368.151 1.00 18.47 ? 132 PHE B O   1 
ATOM   2001 C CB  . PHE B 2 132 ? 222.455 240.142 365.932 1.00 15.43 ? 132 PHE B CB  1 
ATOM   2002 C CG  . PHE B 2 132 ? 221.773 240.978 364.893 1.00 13.26 ? 132 PHE B CG  1 
ATOM   2003 C CD1 . PHE B 2 132 ? 221.196 242.187 365.233 1.00 12.00 ? 132 PHE B CD1 1 
ATOM   2004 C CD2 . PHE B 2 132 ? 221.707 240.560 363.578 1.00 17.84 ? 132 PHE B CD2 1 
ATOM   2005 C CE1 . PHE B 2 132 ? 220.572 242.961 364.285 1.00 19.16 ? 132 PHE B CE1 1 
ATOM   2006 C CE2 . PHE B 2 132 ? 221.078 241.333 362.625 1.00 16.09 ? 132 PHE B CE2 1 
ATOM   2007 C CZ  . PHE B 2 132 ? 220.513 242.533 362.980 1.00 18.25 ? 132 PHE B CZ  1 
ATOM   2008 N N   . TYR B 2 133 ? 223.921 241.302 368.737 1.00 8.09  ? 133 TYR B N   1 
ATOM   2009 C CA  . TYR B 2 133 ? 224.031 241.101 370.172 1.00 10.70 ? 133 TYR B CA  1 
ATOM   2010 C C   . TYR B 2 133 ? 222.772 241.632 370.836 1.00 11.04 ? 133 TYR B C   1 
ATOM   2011 O O   . TYR B 2 133 ? 222.280 242.703 370.478 1.00 15.33 ? 133 TYR B O   1 
ATOM   2012 C CB  . TYR B 2 133 ? 225.254 241.817 370.754 1.00 11.35 ? 133 TYR B CB  1 
ATOM   2013 C CG  . TYR B 2 133 ? 226.575 241.392 370.160 1.00 13.96 ? 133 TYR B CG  1 
ATOM   2014 C CD1 . TYR B 2 133 ? 227.248 240.278 370.641 1.00 14.42 ? 133 TYR B CD1 1 
ATOM   2015 C CD2 . TYR B 2 133 ? 227.154 242.111 369.126 1.00 13.65 ? 133 TYR B CD2 1 
ATOM   2016 C CE1 . TYR B 2 133 ? 228.454 239.893 370.108 1.00 15.80 ? 133 TYR B CE1 1 
ATOM   2017 C CE2 . TYR B 2 133 ? 228.359 241.733 368.586 1.00 12.38 ? 133 TYR B CE2 1 
ATOM   2018 C CZ  . TYR B 2 133 ? 229.006 240.623 369.080 1.00 16.38 ? 133 TYR B CZ  1 
ATOM   2019 O OH  . TYR B 2 133 ? 230.210 240.239 368.545 1.00 22.45 ? 133 TYR B OH  1 
ATOM   2020 N N   . THR B 2 134 ? 222.264 240.895 371.814 1.00 13.16 ? 134 THR B N   1 
ATOM   2021 C CA  . THR B 2 134 ? 221.041 241.261 372.511 1.00 10.22 ? 134 THR B CA  1 
ATOM   2022 C C   . THR B 2 134 ? 221.390 241.899 373.847 1.00 7.55  ? 134 THR B C   1 
ATOM   2023 O O   . THR B 2 134 ? 222.061 241.283 374.679 1.00 16.53 ? 134 THR B O   1 
ATOM   2024 C CB  . THR B 2 134 ? 220.146 240.037 372.720 1.00 10.12 ? 134 THR B CB  1 
ATOM   2025 O OG1 . THR B 2 134 ? 219.872 239.422 371.457 1.00 11.37 ? 134 THR B OG1 1 
ATOM   2026 C CG2 . THR B 2 134 ? 218.838 240.427 373.374 1.00 14.52 ? 134 THR B CG2 1 
ATOM   2027 N N   . LEU B 2 135 ? 220.935 243.131 374.045 1.00 7.09  ? 135 LEU B N   1 
ATOM   2028 C CA  . LEU B 2 135 ? 221.127 243.833 375.302 1.00 9.75  ? 135 LEU B CA  1 
ATOM   2029 C C   . LEU B 2 135 ? 220.119 243.329 376.331 1.00 10.08 ? 135 LEU B C   1 
ATOM   2030 O O   . LEU B 2 135 ? 219.243 242.515 376.035 1.00 17.11 ? 135 LEU B O   1 
ATOM   2031 C CB  . LEU B 2 135 ? 220.995 245.340 375.094 1.00 10.48 ? 135 LEU B CB  1 
ATOM   2032 C CG  . LEU B 2 135 ? 222.111 246.068 374.337 1.00 17.87 ? 135 LEU B CG  1 
ATOM   2033 C CD1 . LEU B 2 135 ? 222.401 245.430 372.991 1.00 16.29 ? 135 LEU B CD1 1 
ATOM   2034 C CD2 . LEU B 2 135 ? 221.743 247.531 374.157 1.00 14.27 ? 135 LEU B CD2 1 
ATOM   2035 N N   . ASP B 2 136 ? 220.240 243.814 377.561 1.00 16.85 ? 136 ASP B N   1 
ATOM   2036 C CA  . ASP B 2 136 ? 219.281 243.447 378.592 1.00 14.84 ? 136 ASP B CA  1 
ATOM   2037 C C   . ASP B 2 136 ? 217.917 244.056 378.291 1.00 15.18 ? 136 ASP B C   1 
ATOM   2038 O O   . ASP B 2 136 ? 217.811 245.196 377.833 1.00 17.69 ? 136 ASP B O   1 
ATOM   2039 C CB  . ASP B 2 136 ? 219.777 243.902 379.965 1.00 16.63 ? 136 ASP B CB  1 
ATOM   2040 C CG  . ASP B 2 136 ? 221.008 243.141 380.420 1.00 23.69 ? 136 ASP B CG  1 
ATOM   2041 O OD1 . ASP B 2 136 ? 221.216 242.005 379.945 1.00 21.92 ? 136 ASP B OD1 1 
ATOM   2042 O OD2 . ASP B 2 136 ? 221.768 243.677 381.254 1.00 29.45 ? 136 ASP B OD2 1 
ATOM   2043 N N   . THR B 2 137 ? 216.871 243.278 378.547 1.00 18.89 ? 137 THR B N   1 
ATOM   2044 C CA  . THR B 2 137 ? 215.506 243.727 378.311 1.00 12.94 ? 137 THR B CA  1 
ATOM   2045 C C   . THR B 2 137 ? 215.109 244.799 379.320 1.00 9.50  ? 137 THR B C   1 
ATOM   2046 O O   . THR B 2 137 ? 215.495 244.744 380.490 1.00 20.86 ? 137 THR B O   1 
ATOM   2047 C CB  . THR B 2 137 ? 214.554 242.531 378.397 1.00 11.98 ? 137 THR B CB  1 
ATOM   2048 O OG1 . THR B 2 137 ? 214.773 241.669 377.275 1.00 13.66 ? 137 THR B OG1 1 
ATOM   2049 C CG2 . THR B 2 137 ? 213.096 242.966 378.420 1.00 14.64 ? 137 THR B CG2 1 
ATOM   2050 N N   . VAL B 2 138 ? 214.336 245.782 378.861 1.00 6.99  ? 138 VAL B N   1 
ATOM   2051 C CA  . VAL B 2 138 ? 213.777 246.810 379.734 1.00 11.11 ? 138 VAL B CA  1 
ATOM   2052 C C   . VAL B 2 138 ? 212.275 246.596 379.814 1.00 8.28  ? 138 VAL B C   1 
ATOM   2053 O O   . VAL B 2 138 ? 211.678 245.940 378.958 1.00 11.64 ? 138 VAL B O   1 
ATOM   2054 C CB  . VAL B 2 138 ? 214.101 248.244 379.257 1.00 11.32 ? 138 VAL B CB  1 
ATOM   2055 C CG1 . VAL B 2 138 ? 215.594 248.497 379.315 1.00 9.56  ? 138 VAL B CG1 1 
ATOM   2056 C CG2 . VAL B 2 138 ? 213.567 248.491 377.855 1.00 7.53  ? 138 VAL B CG2 1 
ATOM   2057 N N   . THR B 2 139 ? 211.660 247.141 380.857 1.00 14.14 ? 139 THR B N   1 
ATOM   2058 C CA  . THR B 2 139 ? 210.238 246.945 381.106 1.00 11.31 ? 139 THR B CA  1 
ATOM   2059 C C   . THR B 2 139 ? 209.480 248.242 380.843 1.00 7.09  ? 139 THR B C   1 
ATOM   2060 O O   . THR B 2 139 ? 209.686 249.240 381.538 1.00 8.91  ? 139 THR B O   1 
ATOM   2061 C CB  . THR B 2 139 ? 210.000 246.467 382.537 1.00 10.07 ? 139 THR B CB  1 
ATOM   2062 O OG1 . THR B 2 139 ? 210.824 245.328 382.800 1.00 18.69 ? 139 THR B OG1 1 
ATOM   2063 C CG2 . THR B 2 139 ? 208.549 246.084 382.733 1.00 12.60 ? 139 THR B CG2 1 
ATOM   2064 N N   . TRP B 2 140 ? 208.606 248.217 379.841 1.00 6.62  ? 140 TRP B N   1 
ATOM   2065 C CA  . TRP B 2 140 ? 207.706 249.322 379.543 1.00 6.49  ? 140 TRP B CA  1 
ATOM   2066 C C   . TRP B 2 140 ? 206.510 249.238 380.481 1.00 10.60 ? 140 TRP B C   1 
ATOM   2067 O O   . TRP B 2 140 ? 205.741 248.269 380.441 1.00 16.86 ? 140 TRP B O   1 
ATOM   2068 C CB  . TRP B 2 140 ? 207.275 249.251 378.083 1.00 12.94 ? 140 TRP B CB  1 
ATOM   2069 C CG  . TRP B 2 140 ? 206.421 250.379 377.605 1.00 6.20  ? 140 TRP B CG  1 
ATOM   2070 C CD1 . TRP B 2 140 ? 206.083 251.506 378.285 1.00 6.03  ? 140 TRP B CD1 1 
ATOM   2071 C CD2 . TRP B 2 140 ? 205.794 250.479 376.326 1.00 6.77  ? 140 TRP B CD2 1 
ATOM   2072 N NE1 . TRP B 2 140 ? 205.282 252.302 377.512 1.00 8.63  ? 140 TRP B NE1 1 
ATOM   2073 C CE2 . TRP B 2 140 ? 205.091 251.695 376.301 1.00 10.36 ? 140 TRP B CE2 1 
ATOM   2074 C CE3 . TRP B 2 140 ? 205.759 249.657 375.198 1.00 4.59  ? 140 TRP B CE3 1 
ATOM   2075 C CZ2 . TRP B 2 140 ? 204.360 252.109 375.194 1.00 8.10  ? 140 TRP B CZ2 1 
ATOM   2076 C CZ3 . TRP B 2 140 ? 205.037 250.068 374.103 1.00 5.78  ? 140 TRP B CZ3 1 
ATOM   2077 C CH2 . TRP B 2 140 ? 204.347 251.284 374.106 1.00 8.85  ? 140 TRP B CH2 1 
ATOM   2078 N N   . ARG B 2 141 ? 206.376 250.242 381.339 1.00 12.68 ? 141 ARG B N   1 
ATOM   2079 C CA  . ARG B 2 141 ? 205.264 250.393 382.261 1.00 16.54 ? 141 ARG B CA  1 
ATOM   2080 C C   . ARG B 2 141 ? 204.419 251.588 381.840 1.00 13.24 ? 141 ARG B C   1 
ATOM   2081 O O   . ARG B 2 141 ? 204.755 252.323 380.911 1.00 24.55 ? 141 ARG B O   1 
ATOM   2082 C CB  . ARG B 2 141 ? 205.769 250.581 383.695 1.00 19.11 ? 141 ARG B CB  1 
ATOM   2083 C CG  . ARG B 2 141 ? 206.667 249.467 384.198 1.00 17.00 ? 141 ARG B CG  1 
ATOM   2084 C CD  . ARG B 2 141 ? 207.367 249.877 385.482 1.00 21.39 ? 141 ARG B CD  1 
ATOM   2085 N NE  . ARG B 2 141 ? 208.119 248.782 386.083 1.00 21.49 ? 141 ARG B NE  1 
ATOM   2086 C CZ  . ARG B 2 141 ? 209.371 248.468 385.779 1.00 24.62 ? 141 ARG B CZ  1 
ATOM   2087 N NH1 . ARG B 2 141 ? 210.053 249.137 384.863 1.00 21.98 ? 141 ARG B NH1 1 
ATOM   2088 N NH2 . ARG B 2 141 ? 209.955 247.456 386.412 1.00 22.08 ? 141 ARG B NH2 1 
ATOM   2089 N N   . LYS B 2 142 ? 203.306 251.779 382.546 1.00 20.07 ? 142 LYS B N   1 
ATOM   2090 C CA  . LYS B 2 142 ? 202.458 252.932 382.268 1.00 21.29 ? 142 LYS B CA  1 
ATOM   2091 C C   . LYS B 2 142 ? 203.172 254.239 382.586 1.00 21.42 ? 142 LYS B C   1 
ATOM   2092 O O   . LYS B 2 142 ? 202.953 255.246 381.906 1.00 23.50 ? 142 LYS B O   1 
ATOM   2093 C CB  . LYS B 2 142 ? 201.159 252.836 383.065 1.00 19.65 ? 142 LYS B CB  1 
ATOM   2094 C CG  . LYS B 2 142 ? 200.156 253.918 382.714 1.00 22.92 ? 142 LYS B CG  1 
ATOM   2095 C CD  . LYS B 2 142 ? 198.908 253.826 383.563 1.00 27.26 ? 142 LYS B CD  1 
ATOM   2096 C CE  . LYS B 2 142 ? 197.823 254.747 383.039 1.00 28.93 ? 142 LYS B CE  1 
ATOM   2097 N NZ  . LYS B 2 142 ? 198.304 256.144 382.861 1.00 23.77 ? 142 LYS B NZ  1 
ATOM   2098 N N   . GLU B 2 143 ? 204.028 254.243 383.604 1.00 18.59 ? 143 GLU B N   1 
ATOM   2099 C CA  . GLU B 2 143 ? 204.690 255.451 384.070 1.00 17.50 ? 143 GLU B CA  1 
ATOM   2100 C C   . GLU B 2 143 ? 206.110 255.596 383.533 1.00 21.09 ? 143 GLU B C   1 
ATOM   2101 O O   . GLU B 2 143 ? 206.843 256.480 383.984 1.00 22.86 ? 143 GLU B O   1 
ATOM   2102 C CB  . GLU B 2 143 ? 204.703 255.487 385.601 1.00 17.04 ? 143 GLU B CB  1 
ATOM   2103 C CG  . GLU B 2 143 ? 205.422 254.322 386.272 1.00 21.77 ? 143 GLU B CG  1 
ATOM   2104 C CD  . GLU B 2 143 ? 204.539 253.098 386.447 1.00 28.15 ? 143 GLU B CD  1 
ATOM   2105 O OE1 . GLU B 2 143 ? 203.600 252.913 385.644 1.00 24.41 ? 143 GLU B OE1 1 
ATOM   2106 O OE2 . GLU B 2 143 ? 204.781 252.323 387.395 1.00 29.35 ? 143 GLU B OE2 1 
ATOM   2107 N N   . SER B 2 144 ? 206.513 254.755 382.585 1.00 16.79 ? 144 SER B N   1 
ATOM   2108 C CA  . SER B 2 144 ? 207.844 254.861 382.006 1.00 9.66  ? 144 SER B CA  1 
ATOM   2109 C C   . SER B 2 144 ? 207.995 256.165 381.234 1.00 9.57  ? 144 SER B C   1 
ATOM   2110 O O   . SER B 2 144 ? 207.064 256.627 380.572 1.00 19.65 ? 144 SER B O   1 
ATOM   2111 C CB  . SER B 2 144 ? 208.114 253.676 381.081 1.00 13.41 ? 144 SER B CB  1 
ATOM   2112 O OG  . SER B 2 144 ? 208.337 252.491 381.820 1.00 18.19 ? 144 SER B OG  1 
ATOM   2113 N N   . ARG B 2 145 ? 209.186 256.757 381.316 1.00 11.43 ? 145 ARG B N   1 
ATOM   2114 C CA  . ARG B 2 145 ? 209.471 258.015 380.642 1.00 9.46  ? 145 ARG B CA  1 
ATOM   2115 C C   . ARG B 2 145 ? 210.334 257.862 379.399 1.00 4.62  ? 145 ARG B C   1 
ATOM   2116 O O   . ARG B 2 145 ? 210.287 258.734 378.527 1.00 10.55 ? 145 ARG B O   1 
ATOM   2117 C CB  . ARG B 2 145 ? 210.162 258.988 381.604 1.00 13.32 ? 145 ARG B CB  1 
ATOM   2118 C CG  . ARG B 2 145 ? 209.274 259.501 382.717 1.00 12.61 ? 145 ARG B CG  1 
ATOM   2119 C CD  . ARG B 2 145 ? 208.040 260.164 382.153 1.00 17.71 ? 145 ARG B CD  1 
ATOM   2120 N NE  . ARG B 2 145 ? 207.474 261.158 383.054 1.00 19.82 ? 145 ARG B NE  1 
ATOM   2121 C CZ  . ARG B 2 145 ? 206.556 262.047 382.700 1.00 19.27 ? 145 ARG B CZ  1 
ATOM   2122 N NH1 . ARG B 2 145 ? 206.076 262.091 381.469 1.00 17.19 ? 145 ARG B NH1 1 
ATOM   2123 N NH2 . ARG B 2 145 ? 206.112 262.914 383.603 1.00 25.30 ? 145 ARG B NH2 1 
ATOM   2124 N N   . GLY B 2 146 ? 211.111 256.789 379.291 1.00 16.35 ? 146 GLY B N   1 
ATOM   2125 C CA  . GLY B 2 146 ? 211.967 256.589 378.138 1.00 11.72 ? 146 GLY B CA  1 
ATOM   2126 C C   . GLY B 2 146 ? 213.314 256.000 378.498 1.00 7.04  ? 146 GLY B C   1 
ATOM   2127 O O   . GLY B 2 146 ? 213.681 255.947 379.673 1.00 11.96 ? 146 GLY B O   1 
ATOM   2128 N N   . TRP B 2 147 ? 214.061 255.566 377.487 1.00 3.84  ? 147 TRP B N   1 
ATOM   2129 C CA  . TRP B 2 147 ? 215.343 254.905 377.678 1.00 4.66  ? 147 TRP B CA  1 
ATOM   2130 C C   . TRP B 2 147 ? 216.334 255.452 376.664 1.00 6.51  ? 147 TRP B C   1 
ATOM   2131 O O   . TRP B 2 147 ? 215.945 255.938 375.601 1.00 6.59  ? 147 TRP B O   1 
ATOM   2132 C CB  . TRP B 2 147 ? 215.215 253.381 377.520 1.00 6.44  ? 147 TRP B CB  1 
ATOM   2133 C CG  . TRP B 2 147 ? 214.190 252.767 378.429 1.00 5.22  ? 147 TRP B CG  1 
ATOM   2134 C CD1 . TRP B 2 147 ? 214.404 252.257 379.669 1.00 2.36  ? 147 TRP B CD1 1 
ATOM   2135 C CD2 . TRP B 2 147 ? 212.788 252.613 378.169 1.00 5.10  ? 147 TRP B CD2 1 
ATOM   2136 N NE1 . TRP B 2 147 ? 213.231 251.792 380.200 1.00 10.45 ? 147 TRP B NE1 1 
ATOM   2137 C CE2 . TRP B 2 147 ? 212.222 251.998 379.298 1.00 10.33 ? 147 TRP B CE2 1 
ATOM   2138 C CE3 . TRP B 2 147 ? 211.960 252.933 377.090 1.00 4.35  ? 147 TRP B CE3 1 
ATOM   2139 C CZ2 . TRP B 2 147 ? 210.865 251.694 379.382 1.00 10.11 ? 147 TRP B CZ2 1 
ATOM   2140 C CZ3 . TRP B 2 147 ? 210.615 252.632 377.175 1.00 11.55 ? 147 TRP B CZ3 1 
ATOM   2141 C CH2 . TRP B 2 147 ? 210.081 252.016 378.312 1.00 8.54  ? 147 TRP B CH2 1 
ATOM   2142 N N   . TRP B 2 148 ? 217.620 255.379 376.994 1.00 3.52  ? 148 TRP B N   1 
ATOM   2143 C CA  . TRP B 2 148 ? 218.644 255.781 376.043 1.00 8.60  ? 148 TRP B CA  1 
ATOM   2144 C C   . TRP B 2 148 ? 219.871 254.890 376.166 1.00 7.72  ? 148 TRP B C   1 
ATOM   2145 O O   . TRP B 2 148 ? 220.169 254.342 377.229 1.00 8.33  ? 148 TRP B O   1 
ATOM   2146 C CB  . TRP B 2 148 ? 219.042 257.261 376.207 1.00 7.84  ? 148 TRP B CB  1 
ATOM   2147 C CG  . TRP B 2 148 ? 219.529 257.648 377.566 1.00 3.88  ? 148 TRP B CG  1 
ATOM   2148 C CD1 . TRP B 2 148 ? 218.793 258.189 378.573 1.00 8.76  ? 148 TRP B CD1 1 
ATOM   2149 C CD2 . TRP B 2 148 ? 220.869 257.546 378.059 1.00 3.36  ? 148 TRP B CD2 1 
ATOM   2150 N NE1 . TRP B 2 148 ? 219.586 258.424 379.666 1.00 13.73 ? 148 TRP B NE1 1 
ATOM   2151 C CE2 . TRP B 2 148 ? 220.866 258.035 379.376 1.00 4.60  ? 148 TRP B CE2 1 
ATOM   2152 C CE3 . TRP B 2 148 ? 222.069 257.081 377.515 1.00 9.42  ? 148 TRP B CE3 1 
ATOM   2153 C CZ2 . TRP B 2 148 ? 222.014 258.072 380.160 1.00 11.08 ? 148 TRP B CZ2 1 
ATOM   2154 C CZ3 . TRP B 2 148 ? 223.205 257.119 378.292 1.00 9.16  ? 148 TRP B CZ3 1 
ATOM   2155 C CH2 . TRP B 2 148 ? 223.171 257.610 379.601 1.00 8.58  ? 148 TRP B CH2 1 
ATOM   2156 N N   . TRP B 2 149 ? 220.565 254.747 375.040 1.00 12.32 ? 149 TRP B N   1 
ATOM   2157 C CA  . TRP B 2 149 ? 221.822 254.019 374.949 1.00 5.34  ? 149 TRP B CA  1 
ATOM   2158 C C   . TRP B 2 149 ? 222.756 254.781 374.023 1.00 5.85  ? 149 TRP B C   1 
ATOM   2159 O O   . TRP B 2 149 ? 222.324 255.605 373.217 1.00 9.14  ? 149 TRP B O   1 
ATOM   2160 C CB  . TRP B 2 149 ? 221.633 252.591 374.414 1.00 8.21  ? 149 TRP B CB  1 
ATOM   2161 C CG  . TRP B 2 149 ? 220.810 251.703 375.286 1.00 8.07  ? 149 TRP B CG  1 
ATOM   2162 C CD1 . TRP B 2 149 ? 221.264 250.853 376.244 1.00 9.64  ? 149 TRP B CD1 1 
ATOM   2163 C CD2 . TRP B 2 149 ? 219.386 251.567 375.272 1.00 10.43 ? 149 TRP B CD2 1 
ATOM   2164 N NE1 . TRP B 2 149 ? 220.215 250.196 376.831 1.00 11.54 ? 149 TRP B NE1 1 
ATOM   2165 C CE2 . TRP B 2 149 ? 219.049 250.618 376.253 1.00 12.11 ? 149 TRP B CE2 1 
ATOM   2166 C CE3 . TRP B 2 149 ? 218.362 252.160 374.528 1.00 7.38  ? 149 TRP B CE3 1 
ATOM   2167 C CZ2 . TRP B 2 149 ? 217.732 250.247 376.511 1.00 14.64 ? 149 TRP B CZ2 1 
ATOM   2168 C CZ3 . TRP B 2 149 ? 217.060 251.793 374.784 1.00 11.10 ? 149 TRP B CZ3 1 
ATOM   2169 C CH2 . TRP B 2 149 ? 216.754 250.844 375.767 1.00 14.09 ? 149 TRP B CH2 1 
ATOM   2170 N N   . LYS B 2 150 ? 224.047 254.487 374.138 1.00 10.45 ? 150 LYS B N   1 
ATOM   2171 C CA  . LYS B 2 150 ? 225.071 255.076 373.288 1.00 4.33  ? 150 LYS B CA  1 
ATOM   2172 C C   . LYS B 2 150 ? 225.795 253.972 372.532 1.00 4.74  ? 150 LYS B C   1 
ATOM   2173 O O   . LYS B 2 150 ? 226.032 252.891 373.074 1.00 16.01 ? 150 LYS B O   1 
ATOM   2174 C CB  . LYS B 2 150 ? 226.073 255.890 374.107 1.00 6.56  ? 150 LYS B CB  1 
ATOM   2175 C CG  . LYS B 2 150 ? 225.470 257.036 374.889 1.00 6.40  ? 150 LYS B CG  1 
ATOM   2176 C CD  . LYS B 2 150 ? 224.932 258.121 373.977 1.00 11.39 ? 150 LYS B CD  1 
ATOM   2177 C CE  . LYS B 2 150 ? 224.329 259.265 374.770 1.00 11.41 ? 150 LYS B CE  1 
ATOM   2178 N NZ  . LYS B 2 150 ? 225.336 259.955 375.614 1.00 13.67 ? 150 LYS B NZ  1 
ATOM   2179 N N   . LEU B 2 151 ? 226.127 254.243 371.276 1.00 8.37  ? 151 LEU B N   1 
ATOM   2180 C CA  . LEU B 2 151 ? 226.853 253.326 370.428 1.00 9.27  ? 151 LEU B CA  1 
ATOM   2181 C C   . LEU B 2 151 ? 228.141 253.989 369.961 1.00 8.29  ? 151 LEU B C   1 
ATOM   2182 O O   . LEU B 2 151 ? 228.099 255.128 369.465 1.00 10.98 ? 151 LEU B O   1 
ATOM   2183 C CB  . LEU B 2 151 ? 226.010 252.911 369.211 1.00 12.17 ? 151 LEU B CB  1 
ATOM   2184 C CG  . LEU B 2 151 ? 224.783 252.042 369.489 1.00 6.50  ? 151 LEU B CG  1 
ATOM   2185 C CD1 . LEU B 2 151 ? 223.994 251.808 368.214 1.00 12.62 ? 151 LEU B CD1 1 
ATOM   2186 C CD2 . LEU B 2 151 ? 225.201 250.724 370.108 1.00 12.40 ? 151 LEU B CD2 1 
ATOM   2187 N N   . PRO B 2 152 ? 229.296 253.302 370.052 1.00 14.22 ? 152 PRO B N   1 
ATOM   2188 C CA  . PRO B 2 152 ? 229.483 251.876 370.387 1.00 11.98 ? 152 PRO B CA  1 
ATOM   2189 C C   . PRO B 2 152 ? 229.523 251.533 371.876 1.00 4.64  ? 152 PRO B C   1 
ATOM   2190 O O   . PRO B 2 152 ? 229.863 250.413 372.224 1.00 9.61  ? 152 PRO B O   1 
ATOM   2191 C CB  . PRO B 2 152 ? 230.836 251.563 369.737 1.00 12.02 ? 152 PRO B CB  1 
ATOM   2192 C CG  . PRO B 2 152 ? 231.598 252.840 369.861 1.00 9.33  ? 152 PRO B CG  1 
ATOM   2193 C CD  . PRO B 2 152 ? 230.577 253.945 369.709 1.00 9.67  ? 152 PRO B CD  1 
ATOM   2194 N N   . ASP B 2 153 ? 229.177 252.450 372.777 1.00 11.09 ? 153 ASP B N   1 
ATOM   2195 C CA  . ASP B 2 153 ? 229.356 252.192 374.203 1.00 5.45  ? 153 ASP B CA  1 
ATOM   2196 C C   . ASP B 2 153 ? 228.552 250.982 374.670 1.00 14.08 ? 153 ASP B C   1 
ATOM   2197 O O   . ASP B 2 153 ? 229.027 250.195 375.497 1.00 17.09 ? 153 ASP B O   1 
ATOM   2198 C CB  . ASP B 2 153 ? 228.963 253.431 375.004 1.00 4.71  ? 153 ASP B CB  1 
ATOM   2199 C CG  . ASP B 2 153 ? 228.839 253.150 376.482 1.00 13.51 ? 153 ASP B CG  1 
ATOM   2200 O OD1 . ASP B 2 153 ? 229.803 252.626 377.072 1.00 17.31 ? 153 ASP B OD1 1 
ATOM   2201 O OD2 . ASP B 2 153 ? 227.777 253.454 377.058 1.00 21.88 ? 153 ASP B OD2 1 
ATOM   2202 N N   . ALA B 2 154 ? 227.328 250.820 374.167 1.00 14.38 ? 154 ALA B N   1 
ATOM   2203 C CA  . ALA B 2 154 ? 226.467 249.742 374.638 1.00 8.81  ? 154 ALA B CA  1 
ATOM   2204 C C   . ALA B 2 154 ? 227.014 248.359 374.306 1.00 9.75  ? 154 ALA B C   1 
ATOM   2205 O O   . ALA B 2 154 ? 226.651 247.389 374.976 1.00 17.93 ? 154 ALA B O   1 
ATOM   2206 C CB  . ALA B 2 154 ? 225.067 249.896 374.045 1.00 10.86 ? 154 ALA B CB  1 
ATOM   2207 N N   . LEU B 2 155 ? 227.875 248.243 373.298 1.00 9.73  ? 155 LEU B N   1 
ATOM   2208 C CA  . LEU B 2 155 ? 228.409 246.960 372.867 1.00 12.48 ? 155 LEU B CA  1 
ATOM   2209 C C   . LEU B 2 155 ? 229.817 246.694 373.386 1.00 15.07 ? 155 LEU B C   1 
ATOM   2210 O O   . LEU B 2 155 ? 230.480 245.781 372.890 1.00 13.59 ? 155 LEU B O   1 
ATOM   2211 C CB  . LEU B 2 155 ? 228.413 246.878 371.340 1.00 12.55 ? 155 LEU B CB  1 
ATOM   2212 C CG  . LEU B 2 155 ? 227.112 247.201 370.609 1.00 14.31 ? 155 LEU B CG  1 
ATOM   2213 C CD1 . LEU B 2 155 ? 227.345 247.138 369.115 1.00 17.00 ? 155 LEU B CD1 1 
ATOM   2214 C CD2 . LEU B 2 155 ? 225.996 246.258 371.017 1.00 12.91 ? 155 LEU B CD2 1 
ATOM   2215 N N   . LYS B 2 156 ? 230.291 247.462 374.368 1.00 12.10 ? 156 LYS B N   1 
ATOM   2216 C CA  . LYS B 2 156 ? 231.699 247.382 374.745 1.00 14.75 ? 156 LYS B CA  1 
ATOM   2217 C C   . LYS B 2 156 ? 232.063 246.064 375.420 1.00 13.98 ? 156 LYS B C   1 
ATOM   2218 O O   . LYS B 2 156 ? 233.247 245.720 375.464 1.00 15.76 ? 156 LYS B O   1 
ATOM   2219 C CB  . LYS B 2 156 ? 232.071 248.550 375.658 1.00 13.38 ? 156 LYS B CB  1 
ATOM   2220 C CG  . LYS B 2 156 ? 231.449 248.502 377.032 1.00 15.53 ? 156 LYS B CG  1 
ATOM   2221 C CD  . LYS B 2 156 ? 231.694 249.795 377.777 1.00 10.71 ? 156 LYS B CD  1 
ATOM   2222 C CE  . LYS B 2 156 ? 230.888 249.856 379.052 1.00 12.35 ? 156 LYS B CE  1 
ATOM   2223 N NZ  . LYS B 2 156 ? 231.018 251.167 379.727 1.00 14.85 ? 156 LYS B NZ  1 
ATOM   2224 N N   . ASP B 2 157 ? 231.090 245.321 375.938 1.00 16.96 ? 157 ASP B N   1 
ATOM   2225 C CA  . ASP B 2 157 ? 231.334 244.040 376.589 1.00 11.51 ? 157 ASP B CA  1 
ATOM   2226 C C   . ASP B 2 157 ? 230.646 242.906 375.840 1.00 8.96  ? 157 ASP B C   1 
ATOM   2227 O O   . ASP B 2 157 ? 230.086 241.991 376.443 1.00 19.17 ? 157 ASP B O   1 
ATOM   2228 C CB  . ASP B 2 157 ? 230.876 244.074 378.044 1.00 9.67  ? 157 ASP B CB  1 
ATOM   2229 C CG  . ASP B 2 157 ? 231.595 245.130 378.855 1.00 23.86 ? 157 ASP B CG  1 
ATOM   2230 O OD1 . ASP B 2 157 ? 232.743 245.472 378.502 1.00 26.67 ? 157 ASP B OD1 1 
ATOM   2231 O OD2 . ASP B 2 157 ? 231.018 245.621 379.846 1.00 25.69 ? 157 ASP B OD2 1 
ATOM   2232 N N   . MET B 2 158 ? 230.692 242.944 374.514 1.00 7.74  ? 158 MET B N   1 
ATOM   2233 C CA  . MET B 2 158 ? 229.989 241.986 373.665 1.00 10.20 ? 158 MET B CA  1 
ATOM   2234 C C   . MET B 2 158 ? 231.014 241.153 372.901 1.00 16.04 ? 158 MET B C   1 
ATOM   2235 O O   . MET B 2 158 ? 231.436 241.515 371.802 1.00 19.59 ? 158 MET B O   1 
ATOM   2236 C CB  . MET B 2 158 ? 229.039 242.702 372.706 1.00 16.95 ? 158 MET B CB  1 
ATOM   2237 C CG  . MET B 2 158 ? 227.814 243.301 373.372 1.00 14.51 ? 158 MET B CG  1 
ATOM   2238 S SD  . MET B 2 158 ? 226.784 242.067 374.181 1.00 21.21 ? 158 MET B SD  1 
ATOM   2239 C CE  . MET B 2 158 ? 225.448 243.088 374.787 1.00 15.84 ? 158 MET B CE  1 
ATOM   2240 N N   . GLY B 2 159 ? 231.407 240.030 373.494 1.00 16.97 ? 159 GLY B N   1 
ATOM   2241 C CA  . GLY B 2 159 ? 232.214 239.057 372.778 1.00 7.89  ? 159 GLY B CA  1 
ATOM   2242 C C   . GLY B 2 159 ? 233.494 239.654 372.229 1.00 13.68 ? 159 GLY B C   1 
ATOM   2243 O O   . GLY B 2 159 ? 234.226 240.370 372.919 1.00 8.78  ? 159 GLY B O   1 
ATOM   2244 N N   . LEU B 2 160 ? 233.773 239.348 370.964 1.00 17.38 ? 160 LEU B N   1 
ATOM   2245 C CA  . LEU B 2 160 ? 234.995 239.810 370.324 1.00 13.58 ? 160 LEU B CA  1 
ATOM   2246 C C   . LEU B 2 160 ? 234.915 241.255 369.860 1.00 14.34 ? 160 LEU B C   1 
ATOM   2247 O O   . LEU B 2 160 ? 235.959 241.878 369.647 1.00 17.40 ? 160 LEU B O   1 
ATOM   2248 C CB  . LEU B 2 160 ? 235.333 238.914 369.132 1.00 14.67 ? 160 LEU B CB  1 
ATOM   2249 C CG  . LEU B 2 160 ? 235.909 237.540 369.469 1.00 12.15 ? 160 LEU B CG  1 
ATOM   2250 C CD1 . LEU B 2 160 ? 236.005 236.692 368.218 1.00 14.71 ? 160 LEU B CD1 1 
ATOM   2251 C CD2 . LEU B 2 160 ? 237.271 237.666 370.128 1.00 9.97  ? 160 LEU B CD2 1 
ATOM   2252 N N   . PHE B 2 161 ? 233.711 241.809 369.700 1.00 18.75 ? 161 PHE B N   1 
ATOM   2253 C CA  . PHE B 2 161 ? 233.612 243.204 369.288 1.00 11.07 ? 161 PHE B CA  1 
ATOM   2254 C C   . PHE B 2 161 ? 234.164 244.134 370.360 1.00 7.76  ? 161 PHE B C   1 
ATOM   2255 O O   . PHE B 2 161 ? 234.868 245.099 370.048 1.00 11.85 ? 161 PHE B O   1 
ATOM   2256 C CB  . PHE B 2 161 ? 232.165 243.568 368.956 1.00 14.52 ? 161 PHE B CB  1 
ATOM   2257 C CG  . PHE B 2 161 ? 232.008 244.978 368.477 1.00 9.45  ? 161 PHE B CG  1 
ATOM   2258 C CD1 . PHE B 2 161 ? 232.236 245.300 367.153 1.00 11.67 ? 161 PHE B CD1 1 
ATOM   2259 C CD2 . PHE B 2 161 ? 231.672 245.989 369.357 1.00 6.80  ? 161 PHE B CD2 1 
ATOM   2260 C CE1 . PHE B 2 161 ? 232.110 246.597 366.713 1.00 9.82  ? 161 PHE B CE1 1 
ATOM   2261 C CE2 . PHE B 2 161 ? 231.546 247.285 368.922 1.00 10.44 ? 161 PHE B CE2 1 
ATOM   2262 C CZ  . PHE B 2 161 ? 231.766 247.591 367.599 1.00 11.76 ? 161 PHE B CZ  1 
ATOM   2263 N N   . GLY B 2 162 ? 233.854 243.866 371.627 1.00 4.86  ? 162 GLY B N   1 
ATOM   2264 C CA  . GLY B 2 162 ? 234.423 244.667 372.698 1.00 12.96 ? 162 GLY B CA  1 
ATOM   2265 C C   . GLY B 2 162 ? 235.927 244.506 372.806 1.00 11.28 ? 162 GLY B C   1 
ATOM   2266 O O   . GLY B 2 162 ? 236.652 245.473 373.067 1.00 14.72 ? 162 GLY B O   1 
ATOM   2267 N N   . GLN B 2 163 ? 236.418 243.281 372.607 1.00 15.08 ? 163 GLN B N   1 
ATOM   2268 C CA  . GLN B 2 163 ? 237.857 243.054 372.608 1.00 11.30 ? 163 GLN B CA  1 
ATOM   2269 C C   . GLN B 2 163 ? 238.536 243.870 371.519 1.00 12.54 ? 163 GLN B C   1 
ATOM   2270 O O   . GLN B 2 163 ? 239.571 244.498 371.758 1.00 13.53 ? 163 GLN B O   1 
ATOM   2271 C CB  . GLN B 2 163 ? 238.154 241.565 372.420 1.00 10.71 ? 163 GLN B CB  1 
ATOM   2272 C CG  . GLN B 2 163 ? 237.661 240.683 373.547 1.00 7.09  ? 163 GLN B CG  1 
ATOM   2273 C CD  . GLN B 2 163 ? 238.319 241.008 374.865 1.00 8.13  ? 163 GLN B CD  1 
ATOM   2274 O OE1 . GLN B 2 163 ? 239.542 240.991 374.981 1.00 16.46 ? 163 GLN B OE1 1 
ATOM   2275 N NE2 . GLN B 2 163 ? 237.512 241.317 375.867 1.00 13.12 ? 163 GLN B NE2 1 
ATOM   2276 N N   . ASN B 2 164 ? 237.964 243.876 370.315 1.00 11.01 ? 164 ASN B N   1 
ATOM   2277 C CA  . ASN B 2 164 ? 238.537 244.670 369.236 1.00 9.89  ? 164 ASN B CA  1 
ATOM   2278 C C   . ASN B 2 164 ? 238.423 246.161 369.517 1.00 11.04 ? 164 ASN B C   1 
ATOM   2279 O O   . ASN B 2 164 ? 239.322 246.927 369.156 1.00 14.11 ? 164 ASN B O   1 
ATOM   2280 C CB  . ASN B 2 164 ? 237.863 244.322 367.914 1.00 8.13  ? 164 ASN B CB  1 
ATOM   2281 C CG  . ASN B 2 164 ? 238.446 243.085 367.275 1.00 11.89 ? 164 ASN B CG  1 
ATOM   2282 O OD1 . ASN B 2 164 ? 239.159 243.167 366.279 1.00 20.69 ? 164 ASN B OD1 1 
ATOM   2283 N ND2 . ASN B 2 164 ? 238.148 241.927 367.847 1.00 16.79 ? 164 ASN B ND2 1 
ATOM   2284 N N   . MET B 2 165 ? 237.331 246.590 370.153 1.00 16.21 ? 165 MET B N   1 
ATOM   2285 C CA  . MET B 2 165 ? 237.216 247.982 370.567 1.00 9.08  ? 165 MET B CA  1 
ATOM   2286 C C   . MET B 2 165 ? 238.375 248.383 371.464 1.00 12.25 ? 165 MET B C   1 
ATOM   2287 O O   . MET B 2 165 ? 239.019 249.411 371.235 1.00 18.46 ? 165 MET B O   1 
ATOM   2288 C CB  . MET B 2 165 ? 235.897 248.209 371.306 1.00 10.80 ? 165 MET B CB  1 
ATOM   2289 C CG  . MET B 2 165 ? 234.751 248.674 370.441 1.00 13.85 ? 165 MET B CG  1 
ATOM   2290 S SD  . MET B 2 165 ? 233.224 248.910 371.375 1.00 35.37 ? 165 MET B SD  1 
ATOM   2291 C CE  . MET B 2 165 ? 233.668 250.266 372.457 1.00 14.25 ? 165 MET B CE  1 
ATOM   2292 N N   . PHE B 2 166 ? 238.651 247.586 372.489 1.00 11.42 ? 166 PHE B N   1 
ATOM   2293 C CA  . PHE B 2 166 ? 239.629 247.973 373.494 1.00 5.28  ? 166 PHE B CA  1 
ATOM   2294 C C   . PHE B 2 166 ? 241.064 247.630 373.119 1.00 9.35  ? 166 PHE B C   1 
ATOM   2295 O O   . PHE B 2 166 ? 241.986 248.108 373.786 1.00 12.39 ? 166 PHE B O   1 
ATOM   2296 C CB  . PHE B 2 166 ? 239.284 247.326 374.834 1.00 7.88  ? 166 PHE B CB  1 
ATOM   2297 C CG  . PHE B 2 166 ? 238.062 247.899 375.479 1.00 14.82 ? 166 PHE B CG  1 
ATOM   2298 C CD1 . PHE B 2 166 ? 238.033 249.224 375.877 1.00 16.24 ? 166 PHE B CD1 1 
ATOM   2299 C CD2 . PHE B 2 166 ? 236.943 247.117 375.693 1.00 13.55 ? 166 PHE B CD2 1 
ATOM   2300 C CE1 . PHE B 2 166 ? 236.912 249.757 376.468 1.00 11.45 ? 166 PHE B CE1 1 
ATOM   2301 C CE2 . PHE B 2 166 ? 235.818 247.648 376.289 1.00 13.06 ? 166 PHE B CE2 1 
ATOM   2302 C CZ  . PHE B 2 166 ? 235.804 248.968 376.677 1.00 10.12 ? 166 PHE B CZ  1 
ATOM   2303 N N   . TYR B 2 167 ? 241.284 246.828 372.079 1.00 9.13  ? 167 TYR B N   1 
ATOM   2304 C CA  . TYR B 2 167 ? 242.636 246.514 371.642 1.00 13.15 ? 167 TYR B CA  1 
ATOM   2305 C C   . TYR B 2 167 ? 243.158 247.443 370.556 1.00 10.03 ? 167 TYR B C   1 
ATOM   2306 O O   . TYR B 2 167 ? 244.354 247.400 370.256 1.00 6.90  ? 167 TYR B O   1 
ATOM   2307 C CB  . TYR B 2 167 ? 242.712 245.070 371.130 1.00 10.17 ? 167 TYR B CB  1 
ATOM   2308 C CG  . TYR B 2 167 ? 243.138 244.079 372.184 1.00 5.12  ? 167 TYR B CG  1 
ATOM   2309 C CD1 . TYR B 2 167 ? 244.425 244.101 372.702 1.00 13.73 ? 167 TYR B CD1 1 
ATOM   2310 C CD2 . TYR B 2 167 ? 242.258 243.121 372.659 1.00 10.54 ? 167 TYR B CD2 1 
ATOM   2311 C CE1 . TYR B 2 167 ? 244.820 243.199 373.667 1.00 10.61 ? 167 TYR B CE1 1 
ATOM   2312 C CE2 . TYR B 2 167 ? 242.646 242.213 373.619 1.00 11.12 ? 167 TYR B CE2 1 
ATOM   2313 C CZ  . TYR B 2 167 ? 243.926 242.258 374.121 1.00 6.67  ? 167 TYR B CZ  1 
ATOM   2314 O OH  . TYR B 2 167 ? 244.314 241.359 375.081 1.00 11.94 ? 167 TYR B OH  1 
ATOM   2315 N N   . HIS B 2 168 ? 242.310 248.276 369.964 1.00 11.94 ? 168 HIS B N   1 
ATOM   2316 C CA  . HIS B 2 168 ? 242.716 249.139 368.868 1.00 6.12  ? 168 HIS B CA  1 
ATOM   2317 C C   . HIS B 2 168 ? 242.546 250.602 369.246 1.00 6.88  ? 168 HIS B C   1 
ATOM   2318 O O   . HIS B 2 168 ? 241.677 250.962 370.042 1.00 6.90  ? 168 HIS B O   1 
ATOM   2319 C CB  . HIS B 2 168 ? 241.920 248.836 367.601 1.00 3.70  ? 168 HIS B CB  1 
ATOM   2320 C CG  . HIS B 2 168 ? 242.182 247.476 367.038 1.00 7.28  ? 168 HIS B CG  1 
ATOM   2321 N ND1 . HIS B 2 168 ? 241.523 246.348 367.477 1.00 5.32  ? 168 HIS B ND1 1 
ATOM   2322 C CD2 . HIS B 2 168 ? 243.029 247.062 366.067 1.00 7.19  ? 168 HIS B CD2 1 
ATOM   2323 C CE1 . HIS B 2 168 ? 241.952 245.299 366.801 1.00 7.09  ? 168 HIS B CE1 1 
ATOM   2324 N NE2 . HIS B 2 168 ? 242.866 245.705 365.939 1.00 15.89 ? 168 HIS B NE2 1 
ATOM   2325 N N   . TYR B 2 169 ? 243.408 251.436 368.670 1.00 9.49  ? 169 TYR B N   1 
ATOM   2326 C CA  . TYR B 2 169 ? 243.314 252.877 368.850 1.00 5.00  ? 169 TYR B CA  1 
ATOM   2327 C C   . TYR B 2 169 ? 242.121 253.455 368.095 1.00 7.71  ? 169 TYR B C   1 
ATOM   2328 O O   . TYR B 2 169 ? 241.394 254.297 368.632 1.00 12.80 ? 169 TYR B O   1 
ATOM   2329 C CB  . TYR B 2 169 ? 244.631 253.516 368.397 1.00 5.50  ? 169 TYR B CB  1 
ATOM   2330 C CG  . TYR B 2 169 ? 244.612 255.010 368.166 1.00 6.38  ? 169 TYR B CG  1 
ATOM   2331 C CD1 . TYR B 2 169 ? 244.031 255.874 369.079 1.00 8.76  ? 169 TYR B CD1 1 
ATOM   2332 C CD2 . TYR B 2 169 ? 245.217 255.557 367.045 1.00 2.49  ? 169 TYR B CD2 1 
ATOM   2333 C CE1 . TYR B 2 169 ? 244.026 257.233 368.869 1.00 2.12  ? 169 TYR B CE1 1 
ATOM   2334 C CE2 . TYR B 2 169 ? 245.218 256.915 366.826 1.00 5.46  ? 169 TYR B CE2 1 
ATOM   2335 C CZ  . TYR B 2 169 ? 244.625 257.749 367.742 1.00 4.18  ? 169 TYR B CZ  1 
ATOM   2336 O OH  . TYR B 2 169 ? 244.629 259.103 367.525 1.00 7.12  ? 169 TYR B OH  1 
ATOM   2337 N N   . LEU B 2 170 ? 241.887 252.994 366.871 1.00 7.44  ? 170 LEU B N   1 
ATOM   2338 C CA  . LEU B 2 170 ? 240.864 253.545 365.994 1.00 6.70  ? 170 LEU B CA  1 
ATOM   2339 C C   . LEU B 2 170 ? 239.891 252.451 365.587 1.00 7.40  ? 170 LEU B C   1 
ATOM   2340 O O   . LEU B 2 170 ? 240.303 251.323 365.306 1.00 6.06  ? 170 LEU B O   1 
ATOM   2341 C CB  . LEU B 2 170 ? 241.493 254.171 364.747 1.00 11.17 ? 170 LEU B CB  1 
ATOM   2342 C CG  . LEU B 2 170 ? 242.490 255.304 364.977 1.00 11.22 ? 170 LEU B CG  1 
ATOM   2343 C CD1 . LEU B 2 170 ? 243.142 255.712 363.670 1.00 6.65  ? 170 LEU B CD1 1 
ATOM   2344 C CD2 . LEU B 2 170 ? 241.823 256.496 365.643 1.00 5.61  ? 170 LEU B CD2 1 
ATOM   2345 N N   . GLY B 2 171 ? 238.611 252.788 365.547 1.00 16.11 ? 171 GLY B N   1 
ATOM   2346 C CA  . GLY B 2 171 ? 237.602 251.869 365.052 1.00 7.20  ? 171 GLY B CA  1 
ATOM   2347 C C   . GLY B 2 171 ? 236.419 252.620 364.490 1.00 7.08  ? 171 GLY B C   1 
ATOM   2348 O O   . GLY B 2 171 ? 236.114 253.739 364.912 1.00 16.02 ? 171 GLY B O   1 
ATOM   2349 N N   . ARG B 2 172 ? 235.754 252.004 363.517 1.00 9.45  ? 172 ARG B N   1 
ATOM   2350 C CA  . ARG B 2 172 ? 234.512 252.541 362.975 1.00 10.60 ? 172 ARG B CA  1 
ATOM   2351 C C   . ARG B 2 172 ? 233.562 251.405 362.637 1.00 14.29 ? 172 ARG B C   1 
ATOM   2352 O O   . ARG B 2 172 ? 233.995 250.308 362.271 1.00 14.95 ? 172 ARG B O   1 
ATOM   2353 C CB  . ARG B 2 172 ? 234.747 253.398 361.724 1.00 10.39 ? 172 ARG B CB  1 
ATOM   2354 C CG  . ARG B 2 172 ? 235.283 252.639 360.530 1.00 16.78 ? 172 ARG B CG  1 
ATOM   2355 C CD  . ARG B 2 172 ? 235.231 253.490 359.285 1.00 16.02 ? 172 ARG B CD  1 
ATOM   2356 N NE  . ARG B 2 172 ? 233.926 253.457 358.638 1.00 14.90 ? 172 ARG B NE  1 
ATOM   2357 C CZ  . ARG B 2 172 ? 233.520 254.325 357.720 1.00 18.36 ? 172 ARG B CZ  1 
ATOM   2358 N NH1 . ARG B 2 172 ? 234.275 255.346 357.349 1.00 15.67 ? 172 ARG B NH1 1 
ATOM   2359 N NH2 . ARG B 2 172 ? 232.324 254.170 357.166 1.00 15.44 ? 172 ARG B NH2 1 
ATOM   2360 N N   . ALA B 2 173 ? 232.266 251.681 362.750 1.00 15.89 ? 173 ALA B N   1 
ATOM   2361 C CA  . ALA B 2 173 ? 231.243 250.706 362.408 1.00 12.37 ? 173 ALA B CA  1 
ATOM   2362 C C   . ALA B 2 173 ? 229.902 251.406 362.255 1.00 12.83 ? 173 ALA B C   1 
ATOM   2363 O O   . ALA B 2 173 ? 229.601 252.365 362.968 1.00 12.54 ? 173 ALA B O   1 
ATOM   2364 C CB  . ALA B 2 173 ? 231.137 249.609 363.473 1.00 10.60 ? 173 ALA B CB  1 
ATOM   2365 N N   . GLY B 2 174 ? 229.105 250.915 361.305 1.00 18.26 ? 174 GLY B N   1 
ATOM   2366 C CA  . GLY B 2 174 ? 227.683 251.177 361.306 1.00 8.37  ? 174 GLY B CA  1 
ATOM   2367 C C   . GLY B 2 174 ? 226.961 250.196 362.208 1.00 12.41 ? 174 GLY B C   1 
ATOM   2368 O O   . GLY B 2 174 ? 227.569 249.333 362.823 1.00 10.02 ? 174 GLY B O   1 
ATOM   2369 N N   . TYR B 2 175 ? 225.641 250.327 362.271 1.00 12.57 ? 175 TYR B N   1 
ATOM   2370 C CA  . TYR B 2 175 ? 224.844 249.472 363.136 1.00 11.72 ? 175 TYR B CA  1 
ATOM   2371 C C   . TYR B 2 175 ? 223.518 249.130 362.481 1.00 10.06 ? 175 TYR B C   1 
ATOM   2372 O O   . TYR B 2 175 ? 223.020 249.853 361.620 1.00 13.11 ? 175 TYR B O   1 
ATOM   2373 C CB  . TYR B 2 175 ? 224.585 250.130 364.491 1.00 10.17 ? 175 TYR B CB  1 
ATOM   2374 C CG  . TYR B 2 175 ? 225.851 250.562 365.176 1.00 12.84 ? 175 TYR B CG  1 
ATOM   2375 C CD1 . TYR B 2 175 ? 226.549 249.694 366.002 1.00 13.60 ? 175 TYR B CD1 1 
ATOM   2376 C CD2 . TYR B 2 175 ? 226.364 251.833 364.975 1.00 10.59 ? 175 TYR B CD2 1 
ATOM   2377 C CE1 . TYR B 2 175 ? 227.712 250.088 366.620 1.00 13.54 ? 175 TYR B CE1 1 
ATOM   2378 C CE2 . TYR B 2 175 ? 227.521 252.233 365.585 1.00 10.46 ? 175 TYR B CE2 1 
ATOM   2379 C CZ  . TYR B 2 175 ? 228.194 251.361 366.405 1.00 16.20 ? 175 TYR B CZ  1 
ATOM   2380 O OH  . TYR B 2 175 ? 229.352 251.771 367.009 1.00 19.79 ? 175 TYR B OH  1 
ATOM   2381 N N   . THR B 2 176 ? 222.967 247.999 362.892 1.00 15.06 ? 176 THR B N   1 
ATOM   2382 C CA  . THR B 2 176 ? 221.586 247.637 362.622 1.00 11.58 ? 176 THR B CA  1 
ATOM   2383 C C   . THR B 2 176 ? 220.922 247.398 363.966 1.00 9.13  ? 176 THR B C   1 
ATOM   2384 O O   . THR B 2 176 ? 221.311 246.484 364.697 1.00 13.12 ? 176 THR B O   1 
ATOM   2385 C CB  . THR B 2 176 ? 221.492 246.401 361.729 1.00 15.98 ? 176 THR B CB  1 
ATOM   2386 O OG1 . THR B 2 176 ? 222.040 246.701 360.442 1.00 18.21 ? 176 THR B OG1 1 
ATOM   2387 C CG2 . THR B 2 176 ? 220.045 245.962 361.562 1.00 13.40 ? 176 THR B CG2 1 
ATOM   2388 N N   . VAL B 2 177 ? 219.950 248.239 364.298 1.00 8.55  ? 177 VAL B N   1 
ATOM   2389 C CA  . VAL B 2 177 ? 219.266 248.211 365.583 1.00 12.77 ? 177 VAL B CA  1 
ATOM   2390 C C   . VAL B 2 177 ? 217.874 247.648 365.356 1.00 9.45  ? 177 VAL B C   1 
ATOM   2391 O O   . VAL B 2 177 ? 217.142 248.122 364.480 1.00 17.85 ? 177 VAL B O   1 
ATOM   2392 C CB  . VAL B 2 177 ? 219.202 249.613 366.215 1.00 11.59 ? 177 VAL B CB  1 
ATOM   2393 C CG1 . VAL B 2 177 ? 218.526 249.560 367.573 1.00 14.18 ? 177 VAL B CG1 1 
ATOM   2394 C CG2 . VAL B 2 177 ? 220.592 250.205 366.329 1.00 12.86 ? 177 VAL B CG2 1 
ATOM   2395 N N   . HIS B 2 178 ? 217.514 246.638 366.140 1.00 10.82 ? 178 HIS B N   1 
ATOM   2396 C CA  . HIS B 2 178 ? 216.231 245.957 366.036 1.00 12.97 ? 178 HIS B CA  1 
ATOM   2397 C C   . HIS B 2 178 ? 215.575 246.013 367.407 1.00 9.28  ? 178 HIS B C   1 
ATOM   2398 O O   . HIS B 2 178 ? 216.060 245.395 368.359 1.00 6.04  ? 178 HIS B O   1 
ATOM   2399 C CB  . HIS B 2 178 ? 216.418 244.517 365.562 1.00 9.14  ? 178 HIS B CB  1 
ATOM   2400 C CG  . HIS B 2 178 ? 215.138 243.817 365.229 1.00 10.73 ? 178 HIS B CG  1 
ATOM   2401 N ND1 . HIS B 2 178 ? 214.206 244.341 364.362 1.00 12.95 ? 178 HIS B ND1 1 
ATOM   2402 C CD2 . HIS B 2 178 ? 214.642 242.628 365.640 1.00 18.75 ? 178 HIS B CD2 1 
ATOM   2403 C CE1 . HIS B 2 178 ? 213.188 243.508 364.257 1.00 15.24 ? 178 HIS B CE1 1 
ATOM   2404 N NE2 . HIS B 2 178 ? 213.428 242.460 365.021 1.00 19.97 ? 178 HIS B NE2 1 
ATOM   2405 N N   . VAL B 2 179 ? 214.496 246.778 367.507 1.00 10.20 ? 179 VAL B N   1 
ATOM   2406 C CA  . VAL B 2 179 ? 213.714 246.899 368.730 1.00 10.82 ? 179 VAL B CA  1 
ATOM   2407 C C   . VAL B 2 179 ? 212.532 245.951 368.621 1.00 9.01  ? 179 VAL B C   1 
ATOM   2408 O O   . VAL B 2 179 ? 211.832 245.944 367.602 1.00 15.91 ? 179 VAL B O   1 
ATOM   2409 C CB  . VAL B 2 179 ? 213.245 248.347 368.953 1.00 10.86 ? 179 VAL B CB  1 
ATOM   2410 C CG1 . VAL B 2 179 ? 212.515 248.471 370.274 1.00 14.04 ? 179 VAL B CG1 1 
ATOM   2411 C CG2 . VAL B 2 179 ? 214.424 249.300 368.899 1.00 12.44 ? 179 VAL B CG2 1 
ATOM   2412 N N   . GLN B 2 180 ? 212.317 245.150 369.662 1.00 9.33  ? 180 GLN B N   1 
ATOM   2413 C CA  . GLN B 2 180 ? 211.299 244.109 369.685 1.00 10.46 ? 180 GLN B CA  1 
ATOM   2414 C C   . GLN B 2 180 ? 210.399 244.329 370.890 1.00 9.10  ? 180 GLN B C   1 
ATOM   2415 O O   . GLN B 2 180 ? 210.883 244.400 372.026 1.00 8.86  ? 180 GLN B O   1 
ATOM   2416 C CB  . GLN B 2 180 ? 211.945 242.725 369.745 1.00 11.39 ? 180 GLN B CB  1 
ATOM   2417 C CG  . GLN B 2 180 ? 212.866 242.426 368.576 1.00 12.42 ? 180 GLN B CG  1 
ATOM   2418 C CD  . GLN B 2 180 ? 214.137 241.726 369.000 1.00 11.92 ? 180 GLN B CD  1 
ATOM   2419 O OE1 . GLN B 2 180 ? 214.225 240.501 368.962 1.00 18.33 ? 180 GLN B OE1 1 
ATOM   2420 N NE2 . GLN B 2 180 ? 215.132 242.502 369.411 1.00 12.96 ? 180 GLN B NE2 1 
ATOM   2421 N N   . CYS B 2 181 ? 209.095 244.435 370.638 1.00 13.04 ? 181 CYS B N   1 
ATOM   2422 C CA  . CYS B 2 181 ? 208.115 244.686 371.692 1.00 15.13 ? 181 CYS B CA  1 
ATOM   2423 C C   . CYS B 2 181 ? 206.755 244.216 371.193 1.00 14.77 ? 181 CYS B C   1 
ATOM   2424 O O   . CYS B 2 181 ? 206.161 244.867 370.330 1.00 19.62 ? 181 CYS B O   1 
ATOM   2425 C CB  . CYS B 2 181 ? 208.080 246.167 372.056 1.00 11.94 ? 181 CYS B CB  1 
ATOM   2426 S SG  . CYS B 2 181 ? 206.918 246.589 373.354 1.00 28.77 ? 181 CYS B SG  1 
ATOM   2427 N N   . ASN B 2 182 ? 206.255 243.114 371.742 1.00 9.13  ? 182 ASN B N   1 
ATOM   2428 C CA  . ASN B 2 182 ? 204.979 242.549 371.330 1.00 6.94  ? 182 ASN B CA  1 
ATOM   2429 C C   . ASN B 2 182 ? 203.952 242.655 372.450 1.00 4.01  ? 182 ASN B C   1 
ATOM   2430 O O   . ASN B 2 182 ? 204.292 242.653 373.635 1.00 10.02 ? 182 ASN B O   1 
ATOM   2431 C CB  . ASN B 2 182 ? 205.126 241.082 370.903 1.00 10.68 ? 182 ASN B CB  1 
ATOM   2432 C CG  . ASN B 2 182 ? 205.825 240.234 371.940 1.00 8.06  ? 182 ASN B CG  1 
ATOM   2433 O OD1 . ASN B 2 182 ? 207.022 239.994 371.844 1.00 10.79 ? 182 ASN B OD1 1 
ATOM   2434 N ND2 . ASN B 2 182 ? 205.081 239.773 372.934 1.00 9.10  ? 182 ASN B ND2 1 
ATOM   2435 N N   . ALA B 2 183 ? 202.688 242.754 372.049 1.00 7.98  ? 183 ALA B N   1 
ATOM   2436 C CA  . ALA B 2 183 ? 201.568 242.809 372.974 1.00 8.53  ? 183 ALA B CA  1 
ATOM   2437 C C   . ALA B 2 183 ? 200.347 242.236 372.270 1.00 9.34  ? 183 ALA B C   1 
ATOM   2438 O O   . ALA B 2 183 ? 200.414 241.821 371.111 1.00 19.76 ? 183 ALA B O   1 
ATOM   2439 C CB  . ALA B 2 183 ? 201.314 244.240 373.456 1.00 10.08 ? 183 ALA B CB  1 
ATOM   2440 N N   . SER B 2 184 ? 199.226 242.218 372.973 1.00 7.81  ? 184 SER B N   1 
ATOM   2441 C CA  . SER B 2 184 ? 197.994 241.687 372.417 1.00 9.55  ? 184 SER B CA  1 
ATOM   2442 C C   . SER B 2 184 ? 197.288 242.744 371.574 1.00 6.25  ? 184 SER B C   1 
ATOM   2443 O O   . SER B 2 184 ? 197.684 243.909 371.525 1.00 14.16 ? 184 SER B O   1 
ATOM   2444 C CB  . SER B 2 184 ? 197.073 241.196 373.532 1.00 6.23  ? 184 SER B CB  1 
ATOM   2445 O OG  . SER B 2 184 ? 196.618 242.273 374.327 1.00 10.51 ? 184 SER B OG  1 
ATOM   2446 N N   . LYS B 2 185 ? 196.224 242.314 370.898 1.00 12.15 ? 185 LYS B N   1 
ATOM   2447 C CA  . LYS B 2 185 ? 195.362 243.235 370.171 1.00 9.26  ? 185 LYS B CA  1 
ATOM   2448 C C   . LYS B 2 185 ? 194.532 244.107 371.101 1.00 7.09  ? 185 LYS B C   1 
ATOM   2449 O O   . LYS B 2 185 ? 193.883 245.043 370.628 1.00 9.79  ? 185 LYS B O   1 
ATOM   2450 C CB  . LYS B 2 185 ? 194.440 242.456 369.236 1.00 8.66  ? 185 LYS B CB  1 
ATOM   2451 C CG  . LYS B 2 185 ? 195.161 241.682 368.152 1.00 6.25  ? 185 LYS B CG  1 
ATOM   2452 C CD  . LYS B 2 185 ? 194.194 240.809 367.381 1.00 10.65 ? 185 LYS B CD  1 
ATOM   2453 C CE  . LYS B 2 185 ? 194.896 239.972 366.331 1.00 10.93 ? 185 LYS B CE  1 
ATOM   2454 N NZ  . LYS B 2 185 ? 195.478 240.805 365.246 1.00 13.42 ? 185 LYS B NZ  1 
ATOM   2455 N N   . PHE B 2 186 ? 194.531 243.817 372.399 1.00 8.73  ? 186 PHE B N   1 
ATOM   2456 C CA  . PHE B 2 186 ? 193.815 244.604 373.390 1.00 10.68 ? 186 PHE B CA  1 
ATOM   2457 C C   . PHE B 2 186 ? 194.732 245.549 374.158 1.00 9.55  ? 186 PHE B C   1 
ATOM   2458 O O   . PHE B 2 186 ? 194.279 246.210 375.094 1.00 12.92 ? 186 PHE B O   1 
ATOM   2459 C CB  . PHE B 2 186 ? 193.073 243.670 374.351 1.00 10.31 ? 186 PHE B CB  1 
ATOM   2460 C CG  . PHE B 2 186 ? 192.019 242.832 373.681 1.00 13.01 ? 186 PHE B CG  1 
ATOM   2461 C CD1 . PHE B 2 186 ? 192.372 241.756 372.884 1.00 8.03  ? 186 PHE B CD1 1 
ATOM   2462 C CD2 . PHE B 2 186 ? 190.675 243.124 373.842 1.00 6.98  ? 186 PHE B CD2 1 
ATOM   2463 C CE1 . PHE B 2 186 ? 191.410 240.990 372.265 1.00 1.56  ? 186 PHE B CE1 1 
ATOM   2464 C CE2 . PHE B 2 186 ? 189.708 242.360 373.225 1.00 4.97  ? 186 PHE B CE2 1 
ATOM   2465 C CZ  . PHE B 2 186 ? 190.076 241.291 372.434 1.00 9.50  ? 186 PHE B CZ  1 
ATOM   2466 N N   . HIS B 2 187 ? 196.006 245.622 373.788 1.00 9.48  ? 187 HIS B N   1 
ATOM   2467 C CA  . HIS B 2 187 ? 196.929 246.620 374.306 1.00 12.93 ? 187 HIS B CA  1 
ATOM   2468 C C   . HIS B 2 187 ? 196.947 247.832 373.382 1.00 10.89 ? 187 HIS B C   1 
ATOM   2469 O O   . HIS B 2 187 ? 196.663 247.726 372.187 1.00 7.04  ? 187 HIS B O   1 
ATOM   2470 C CB  . HIS B 2 187 ? 198.350 246.057 374.428 1.00 9.38  ? 187 HIS B CB  1 
ATOM   2471 C CG  . HIS B 2 187 ? 198.565 245.184 375.624 1.00 9.84  ? 187 HIS B CG  1 
ATOM   2472 N ND1 . HIS B 2 187 ? 198.315 243.829 375.612 1.00 12.80 ? 187 HIS B ND1 1 
ATOM   2473 C CD2 . HIS B 2 187 ? 199.025 245.469 376.864 1.00 11.98 ? 187 HIS B CD2 1 
ATOM   2474 C CE1 . HIS B 2 187 ? 198.605 243.320 376.795 1.00 12.63 ? 187 HIS B CE1 1 
ATOM   2475 N NE2 . HIS B 2 187 ? 199.036 244.294 377.573 1.00 12.35 ? 187 HIS B NE2 1 
ATOM   2476 N N   . GLN B 2 188 ? 197.277 248.988 373.950 1.00 7.47  ? 188 GLN B N   1 
ATOM   2477 C CA  . GLN B 2 188 ? 197.498 250.200 373.177 1.00 10.97 ? 188 GLN B CA  1 
ATOM   2478 C C   . GLN B 2 188 ? 198.734 250.915 373.706 1.00 13.10 ? 188 GLN B C   1 
ATOM   2479 O O   . GLN B 2 188 ? 199.083 250.799 374.883 1.00 13.30 ? 188 GLN B O   1 
ATOM   2480 C CB  . GLN B 2 188 ? 196.280 251.141 373.223 1.00 7.98  ? 188 GLN B CB  1 
ATOM   2481 C CG  . GLN B 2 188 ? 195.994 251.740 374.583 1.00 6.34  ? 188 GLN B CG  1 
ATOM   2482 C CD  . GLN B 2 188 ? 194.753 252.607 374.592 1.00 15.98 ? 188 GLN B CD  1 
ATOM   2483 O OE1 . GLN B 2 188 ? 193.919 252.523 373.696 1.00 12.00 ? 188 GLN B OE1 1 
ATOM   2484 N NE2 . GLN B 2 188 ? 194.625 253.448 375.609 1.00 18.64 ? 188 GLN B NE2 1 
ATOM   2485 N N   . GLY B 2 189 ? 199.391 251.645 372.827 1.00 9.10  ? 189 GLY B N   1 
ATOM   2486 C CA  . GLY B 2 189 ? 200.589 252.386 373.163 1.00 7.99  ? 189 GLY B CA  1 
ATOM   2487 C C   . GLY B 2 189 ? 201.464 252.556 371.943 1.00 8.62  ? 189 GLY B C   1 
ATOM   2488 O O   . GLY B 2 189 ? 201.387 251.812 370.970 1.00 9.82  ? 189 GLY B O   1 
ATOM   2489 N N   . ALA B 2 190 ? 202.319 253.571 371.996 1.00 11.94 ? 190 ALA B N   1 
ATOM   2490 C CA  . ALA B 2 190 ? 203.207 253.884 370.888 1.00 9.32  ? 190 ALA B CA  1 
ATOM   2491 C C   . ALA B 2 190 ? 204.576 254.273 371.420 1.00 10.59 ? 190 ALA B C   1 
ATOM   2492 O O   . ALA B 2 190 ? 204.686 255.006 372.403 1.00 12.69 ? 190 ALA B O   1 
ATOM   2493 C CB  . ALA B 2 190 ? 202.641 255.013 370.019 1.00 4.17  ? 190 ALA B CB  1 
ATOM   2494 N N   . LEU B 2 191 ? 205.614 253.781 370.755 1.00 13.91 ? 191 LEU B N   1 
ATOM   2495 C CA  . LEU B 2 191 ? 206.995 254.123 371.057 1.00 11.17 ? 191 LEU B CA  1 
ATOM   2496 C C   . LEU B 2 191 ? 207.617 254.836 369.868 1.00 5.80  ? 191 LEU B C   1 
ATOM   2497 O O   . LEU B 2 191 ? 207.352 254.485 368.717 1.00 12.13 ? 191 LEU B O   1 
ATOM   2498 C CB  . LEU B 2 191 ? 207.828 252.876 371.384 1.00 6.47  ? 191 LEU B CB  1 
ATOM   2499 C CG  . LEU B 2 191 ? 207.539 252.128 372.682 1.00 7.80  ? 191 LEU B CG  1 
ATOM   2500 C CD1 . LEU B 2 191 ? 208.409 250.891 372.774 1.00 6.53  ? 191 LEU B CD1 1 
ATOM   2501 C CD2 . LEU B 2 191 ? 207.745 253.021 373.888 1.00 8.94  ? 191 LEU B CD2 1 
ATOM   2502 N N   . GLY B 2 192 ? 208.439 255.843 370.151 1.00 9.43  ? 192 GLY B N   1 
ATOM   2503 C CA  . GLY B 2 192 ? 209.303 256.440 369.153 1.00 5.37  ? 192 GLY B CA  1 
ATOM   2504 C C   . GLY B 2 192 ? 210.739 256.031 369.422 1.00 6.86  ? 192 GLY B C   1 
ATOM   2505 O O   . GLY B 2 192 ? 211.250 256.219 370.527 1.00 4.71  ? 192 GLY B O   1 
ATOM   2506 N N   . VAL B 2 193 ? 211.371 255.450 368.406 1.00 8.01  ? 193 VAL B N   1 
ATOM   2507 C CA  . VAL B 2 193 ? 212.761 255.014 368.464 1.00 5.25  ? 193 VAL B CA  1 
ATOM   2508 C C   . VAL B 2 193 ? 213.556 255.949 367.563 1.00 8.43  ? 193 VAL B C   1 
ATOM   2509 O O   . VAL B 2 193 ? 213.346 255.975 366.347 1.00 7.38  ? 193 VAL B O   1 
ATOM   2510 C CB  . VAL B 2 193 ? 212.916 253.550 368.027 1.00 8.06  ? 193 VAL B CB  1 
ATOM   2511 C CG1 . VAL B 2 193 ? 214.368 253.110 368.127 1.00 7.55  ? 193 VAL B CG1 1 
ATOM   2512 C CG2 . VAL B 2 193 ? 212.016 252.644 368.858 1.00 11.14 ? 193 VAL B CG2 1 
ATOM   2513 N N   . PHE B 2 194 ? 214.472 256.712 368.151 1.00 6.27  ? 194 PHE B N   1 
ATOM   2514 C CA  . PHE B 2 194 ? 215.223 257.745 367.453 1.00 7.67  ? 194 PHE B CA  1 
ATOM   2515 C C   . PHE B 2 194 ? 216.708 257.421 367.499 1.00 6.80  ? 194 PHE B C   1 
ATOM   2516 O O   . PHE B 2 194 ? 217.241 257.077 368.560 1.00 9.38  ? 194 PHE B O   1 
ATOM   2517 C CB  . PHE B 2 194 ? 214.971 259.118 368.083 1.00 5.68  ? 194 PHE B CB  1 
ATOM   2518 C CG  . PHE B 2 194 ? 213.518 259.484 368.184 1.00 5.18  ? 194 PHE B CG  1 
ATOM   2519 C CD1 . PHE B 2 194 ? 212.871 260.104 367.130 1.00 5.90  ? 194 PHE B CD1 1 
ATOM   2520 C CD2 . PHE B 2 194 ? 212.804 259.218 369.337 1.00 1.42  ? 194 PHE B CD2 1 
ATOM   2521 C CE1 . PHE B 2 194 ? 211.539 260.442 367.224 1.00 5.01  ? 194 PHE B CE1 1 
ATOM   2522 C CE2 . PHE B 2 194 ? 211.477 259.554 369.435 1.00 7.88  ? 194 PHE B CE2 1 
ATOM   2523 C CZ  . PHE B 2 194 ? 210.841 260.168 368.376 1.00 4.01  ? 194 PHE B CZ  1 
ATOM   2524 N N   . ALA B 2 195 ? 217.367 257.534 366.350 1.00 6.94  ? 195 ALA B N   1 
ATOM   2525 C CA  . ALA B 2 195 ? 218.815 257.415 366.247 1.00 6.05  ? 195 ALA B CA  1 
ATOM   2526 C C   . ALA B 2 195 ? 219.396 258.806 366.025 1.00 4.60  ? 195 ALA B C   1 
ATOM   2527 O O   . ALA B 2 195 ? 219.139 259.433 364.994 1.00 6.94  ? 195 ALA B O   1 
ATOM   2528 C CB  . ALA B 2 195 ? 219.208 256.475 365.109 1.00 7.50  ? 195 ALA B CB  1 
ATOM   2529 N N   . VAL B 2 196 ? 220.182 259.275 366.983 1.00 4.89  ? 196 VAL B N   1 
ATOM   2530 C CA  . VAL B 2 196 ? 220.667 260.650 367.033 1.00 5.04  ? 196 VAL B CA  1 
ATOM   2531 C C   . VAL B 2 196 ? 222.184 260.633 366.876 1.00 11.58 ? 196 VAL B C   1 
ATOM   2532 O O   . VAL B 2 196 ? 222.876 260.043 367.712 1.00 4.46  ? 196 VAL B O   1 
ATOM   2533 C CB  . VAL B 2 196 ? 220.263 261.335 368.346 1.00 10.34 ? 196 VAL B CB  1 
ATOM   2534 C CG1 . VAL B 2 196 ? 220.722 262.782 368.353 1.00 3.10  ? 196 VAL B CG1 1 
ATOM   2535 C CG2 . VAL B 2 196 ? 218.763 261.220 368.554 1.00 9.79  ? 196 VAL B CG2 1 
ATOM   2536 N N   . PRO B 2 197 ? 222.744 261.257 365.842 1.00 12.21 ? 197 PRO B N   1 
ATOM   2537 C CA  . PRO B 2 197 ? 224.205 261.401 365.785 1.00 6.17  ? 197 PRO B CA  1 
ATOM   2538 C C   . PRO B 2 197 ? 224.681 262.468 366.761 1.00 3.44  ? 197 PRO B C   1 
ATOM   2539 O O   . PRO B 2 197 ? 224.100 263.550 366.850 1.00 18.12 ? 197 PRO B O   1 
ATOM   2540 C CB  . PRO B 2 197 ? 224.464 261.798 364.329 1.00 6.30  ? 197 PRO B CB  1 
ATOM   2541 C CG  . PRO B 2 197 ? 223.219 262.456 363.897 1.00 9.07  ? 197 PRO B CG  1 
ATOM   2542 C CD  . PRO B 2 197 ? 222.093 261.796 364.636 1.00 8.90  ? 197 PRO B CD  1 
ATOM   2543 N N   . GLU B 2 198 ? 225.744 262.151 367.500 1.00 4.59  ? 198 GLU B N   1 
ATOM   2544 C CA  . GLU B 2 198 ? 226.277 263.041 368.533 1.00 6.01  ? 198 GLU B CA  1 
ATOM   2545 C C   . GLU B 2 198 ? 225.201 263.385 369.560 1.00 4.78  ? 198 GLU B C   1 
ATOM   2546 O O   . GLU B 2 198 ? 224.886 264.550 369.797 1.00 17.73 ? 198 GLU B O   1 
ATOM   2547 C CB  . GLU B 2 198 ? 226.863 264.316 367.919 1.00 4.97  ? 198 GLU B CB  1 
ATOM   2548 C CG  . GLU B 2 198 ? 227.827 264.090 366.774 1.00 3.40  ? 198 GLU B CG  1 
ATOM   2549 C CD  . GLU B 2 198 ? 229.138 263.483 367.214 1.00 11.69 ? 198 GLU B CD  1 
ATOM   2550 O OE1 . GLU B 2 198 ? 229.349 263.311 368.430 1.00 15.11 ? 198 GLU B OE1 1 
ATOM   2551 O OE2 . GLU B 2 198 ? 229.969 263.185 366.338 1.00 25.99 ? 198 GLU B OE2 1 
ATOM   2552 N N   . MET B 2 199 ? 224.634 262.352 370.181 1.00 7.32  ? 199 MET B N   1 
ATOM   2553 C CA  . MET B 2 199 ? 223.550 262.531 371.145 1.00 8.37  ? 199 MET B CA  1 
ATOM   2554 C C   . MET B 2 199 ? 224.138 262.963 372.485 1.00 2.68  ? 199 MET B C   1 
ATOM   2555 O O   . MET B 2 199 ? 224.371 262.163 373.392 1.00 19.21 ? 199 MET B O   1 
ATOM   2556 C CB  . MET B 2 199 ? 222.734 261.250 371.283 1.00 5.46  ? 199 MET B CB  1 
ATOM   2557 C CG  . MET B 2 199 ? 221.340 261.479 371.852 1.00 10.54 ? 199 MET B CG  1 
ATOM   2558 S SD  . MET B 2 199 ? 220.322 259.991 371.929 1.00 15.16 ? 199 MET B SD  1 
ATOM   2559 C CE  . MET B 2 199 ? 220.936 259.247 373.431 1.00 10.32 ? 199 MET B CE  1 
ATOM   2560 N N   . CYS B 2 200 ? 224.370 264.265 372.612 1.00 6.75  ? 200 CYS B N   1 
ATOM   2561 C CA  . CYS B 2 200 ? 224.830 264.837 373.871 1.00 7.20  ? 200 CYS B CA  1 
ATOM   2562 C C   . CYS B 2 200 ? 223.638 265.089 374.784 1.00 7.51  ? 200 CYS B C   1 
ATOM   2563 O O   . CYS B 2 200 ? 222.610 265.612 374.345 1.00 16.76 ? 200 CYS B O   1 
ATOM   2564 C CB  . CYS B 2 200 ? 225.593 266.136 373.623 1.00 10.01 ? 200 CYS B CB  1 
ATOM   2565 S SG  . CYS B 2 200 ? 226.892 266.016 372.375 1.00 23.42 ? 200 CYS B SG  1 
ATOM   2566 N N   . LEU B 2 201 ? 223.774 264.716 376.049 1.00 7.88  ? 201 LEU B N   1 
ATOM   2567 C CA  . LEU B 2 201 ? 222.709 264.851 377.029 1.00 11.74 ? 201 LEU B CA  1 
ATOM   2568 C C   . LEU B 2 201 ? 223.101 265.883 378.075 1.00 7.29  ? 201 LEU B C   1 
ATOM   2569 O O   . LEU B 2 201 ? 224.269 265.975 378.460 1.00 19.91 ? 201 LEU B O   1 
ATOM   2570 C CB  . LEU B 2 201 ? 222.408 263.508 377.702 1.00 10.40 ? 201 LEU B CB  1 
ATOM   2571 C CG  . LEU B 2 201 ? 222.022 262.359 376.765 1.00 17.89 ? 201 LEU B CG  1 
ATOM   2572 C CD1 . LEU B 2 201 ? 221.877 261.060 377.539 1.00 8.62  ? 201 LEU B CD1 1 
ATOM   2573 C CD2 . LEU B 2 201 ? 220.743 262.676 376.003 1.00 15.29 ? 201 LEU B CD2 1 
ATOM   2574 N N   . ALA B 2 202 ? 222.123 266.663 378.522 1.00 13.60 ? 202 ALA B N   1 
ATOM   2575 C CA  . ALA B 2 202 ? 222.377 267.679 379.530 1.00 16.98 ? 202 ALA B CA  1 
ATOM   2576 C C   . ALA B 2 202 ? 222.710 267.033 380.869 1.00 18.09 ? 202 ALA B C   1 
ATOM   2577 O O   . ALA B 2 202 ? 222.231 265.945 381.198 1.00 15.74 ? 202 ALA B O   1 
ATOM   2578 C CB  . ALA B 2 202 ? 221.166 268.597 379.680 1.00 12.10 ? 202 ALA B CB  1 
ATOM   2579 N N   . GLY B 2 203 ? 223.540 267.723 381.645 1.00 16.43 ? 203 GLY B N   1 
ATOM   2580 C CA  . GLY B 2 203 ? 223.962 267.245 382.943 1.00 11.14 ? 203 GLY B CA  1 
ATOM   2581 C C   . GLY B 2 203 ? 222.963 267.582 384.029 1.00 17.93 ? 203 GLY B C   1 
ATOM   2582 O O   . GLY B 2 203 ? 221.793 267.872 383.772 1.00 24.61 ? 203 GLY B O   1 
ATOM   2583 N N   . ASP B 2 204 ? 223.447 267.552 385.272 1.00 23.06 ? 204 ASP B N   1 
ATOM   2584 C CA  . ASP B 2 204 ? 222.593 267.722 386.440 1.00 26.56 ? 204 ASP B CA  1 
ATOM   2585 C C   . ASP B 2 204 ? 223.106 268.776 387.414 1.00 30.02 ? 204 ASP B C   1 
ATOM   2586 O O   . ASP B 2 204 ? 222.533 268.923 388.499 1.00 35.52 ? 204 ASP B O   1 
ATOM   2587 C CB  . ASP B 2 204 ? 222.439 266.389 387.182 1.00 23.64 ? 204 ASP B CB  1 
ATOM   2588 C CG  . ASP B 2 204 ? 223.762 265.854 387.701 1.00 31.23 ? 204 ASP B CG  1 
ATOM   2589 O OD1 . ASP B 2 204 ? 224.819 266.360 387.273 1.00 31.44 ? 204 ASP B OD1 1 
ATOM   2590 O OD2 . ASP B 2 204 ? 223.749 264.930 388.539 1.00 29.49 ? 204 ASP B OD2 1 
ATOM   2591 N N   . SER B 2 205 ? 224.159 269.510 387.069 1.00 26.28 ? 205 SER B N   1 
ATOM   2592 C CA  . SER B 2 205 ? 224.810 270.416 388.002 1.00 28.14 ? 205 SER B CA  1 
ATOM   2593 C C   . SER B 2 205 ? 224.895 271.813 387.404 1.00 27.70 ? 205 SER B C   1 
ATOM   2594 O O   . SER B 2 205 ? 224.717 272.016 386.201 1.00 26.78 ? 205 SER B O   1 
ATOM   2595 C CB  . SER B 2 205 ? 226.214 269.920 388.371 1.00 28.71 ? 205 SER B CB  1 
ATOM   2596 O OG  . SER B 2 205 ? 227.070 269.941 387.246 1.00 29.45 ? 205 SER B OG  1 
ATOM   2597 N N   . THR B 2 206 ? 225.170 272.785 388.276 1.00 29.97 ? 206 THR B N   1 
ATOM   2598 C CA  . THR B 2 206 ? 225.428 274.144 387.823 1.00 29.76 ? 206 THR B CA  1 
ATOM   2599 C C   . THR B 2 206 ? 226.745 274.254 387.068 1.00 27.64 ? 206 THR B C   1 
ATOM   2600 O O   . THR B 2 206 ? 226.972 275.259 386.389 1.00 30.91 ? 206 THR B O   1 
ATOM   2601 C CB  . THR B 2 206 ? 225.434 275.106 389.011 1.00 28.83 ? 206 THR B CB  1 
ATOM   2602 O OG1 . THR B 2 206 ? 226.422 274.691 389.961 1.00 31.33 ? 206 THR B OG1 1 
ATOM   2603 C CG2 . THR B 2 206 ? 224.073 275.134 389.682 1.00 27.76 ? 206 THR B CG2 1 
ATOM   2604 N N   . THR B 2 207 ? 227.613 273.252 387.176 1.00 26.65 ? 207 THR B N   1 
ATOM   2605 C CA  . THR B 2 207 ? 228.851 273.226 386.411 1.00 30.01 ? 207 THR B CA  1 
ATOM   2606 C C   . THR B 2 207 ? 228.577 272.679 385.016 1.00 27.94 ? 207 THR B C   1 
ATOM   2607 O O   . THR B 2 207 ? 227.913 271.651 384.863 1.00 26.67 ? 207 THR B O   1 
ATOM   2608 C CB  . THR B 2 207 ? 229.900 272.369 387.121 1.00 28.59 ? 207 THR B CB  1 
ATOM   2609 O OG1 . THR B 2 207 ? 230.089 272.846 388.458 1.00 31.82 ? 207 THR B OG1 1 
ATOM   2610 C CG2 . THR B 2 207 ? 231.226 272.414 386.382 1.00 26.13 ? 207 THR B CG2 1 
ATOM   2611 N N   . HIS B 2 208 ? 229.086 273.369 384.000 1.00 30.10 ? 208 HIS B N   1 
ATOM   2612 C CA  . HIS B 2 208 ? 228.885 272.924 382.629 1.00 31.68 ? 208 HIS B CA  1 
ATOM   2613 C C   . HIS B 2 208 ? 229.685 271.659 382.355 1.00 28.65 ? 208 HIS B C   1 
ATOM   2614 O O   . HIS B 2 208 ? 230.837 271.530 382.777 1.00 29.77 ? 208 HIS B O   1 
ATOM   2615 C CB  . HIS B 2 208 ? 229.308 274.010 381.639 1.00 31.25 ? 208 HIS B CB  1 
ATOM   2616 C CG  . HIS B 2 208 ? 228.785 275.371 381.967 1.00 28.33 ? 208 HIS B CG  1 
ATOM   2617 N ND1 . HIS B 2 208 ? 229.531 276.515 381.788 1.00 28.29 ? 208 HIS B ND1 1 
ATOM   2618 C CD2 . HIS B 2 208 ? 227.589 275.774 382.454 1.00 30.39 ? 208 HIS B CD2 1 
ATOM   2619 C CE1 . HIS B 2 208 ? 228.818 277.563 382.156 1.00 29.60 ? 208 HIS B CE1 1 
ATOM   2620 N NE2 . HIS B 2 208 ? 227.636 277.141 382.562 1.00 31.42 ? 208 HIS B NE2 1 
ATOM   2621 N N   . MET B 2 209 ? 229.065 270.724 381.636 1.00 26.67 ? 209 MET B N   1 
ATOM   2622 C CA  . MET B 2 209 ? 229.770 269.563 381.098 1.00 28.44 ? 209 MET B CA  1 
ATOM   2623 C C   . MET B 2 209 ? 230.512 268.805 382.197 1.00 25.48 ? 209 MET B C   1 
ATOM   2624 O O   . MET B 2 209 ? 231.655 268.381 382.031 1.00 30.48 ? 209 MET B O   1 
ATOM   2625 C CB  . MET B 2 209 ? 230.727 270.000 379.990 1.00 27.94 ? 209 MET B CB  1 
ATOM   2626 C CG  . MET B 2 209 ? 230.024 270.676 378.817 1.00 26.70 ? 209 MET B CG  1 
ATOM   2627 S SD  . MET B 2 209 ? 231.093 271.736 377.827 1.00 39.08 ? 209 MET B SD  1 
ATOM   2628 C CE  . MET B 2 209 ? 231.411 273.061 378.983 1.00 29.72 ? 209 MET B CE  1 
ATOM   2629 N N   . PHE B 2 210 ? 229.847 268.633 383.335 1.00 22.53 ? 210 PHE B N   1 
ATOM   2630 C CA  . PHE B 2 210 ? 230.449 268.038 384.517 1.00 25.16 ? 210 PHE B CA  1 
ATOM   2631 C C   . PHE B 2 210 ? 230.172 266.544 384.640 1.00 21.86 ? 210 PHE B C   1 
ATOM   2632 O O   . PHE B 2 210 ? 230.627 265.922 385.601 1.00 24.97 ? 210 PHE B O   1 
ATOM   2633 C CB  . PHE B 2 210 ? 229.944 268.775 385.765 1.00 26.50 ? 210 PHE B CB  1 
ATOM   2634 C CG  . PHE B 2 210 ? 230.813 268.608 386.982 1.00 25.37 ? 210 PHE B CG  1 
ATOM   2635 C CD1 . PHE B 2 210 ? 232.194 268.634 386.884 1.00 26.74 ? 210 PHE B CD1 1 
ATOM   2636 C CD2 . PHE B 2 210 ? 230.241 268.465 388.232 1.00 25.75 ? 210 PHE B CD2 1 
ATOM   2637 C CE1 . PHE B 2 210 ? 232.985 268.493 388.005 1.00 24.04 ? 210 PHE B CE1 1 
ATOM   2638 C CE2 . PHE B 2 210 ? 231.028 268.329 389.357 1.00 29.57 ? 210 PHE B CE2 1 
ATOM   2639 C CZ  . PHE B 2 210 ? 232.402 268.343 389.241 1.00 26.66 ? 210 PHE B CZ  1 
ATOM   2640 N N   . THR B 2 211 ? 229.452 265.953 383.690 1.00 20.44 ? 211 THR B N   1 
ATOM   2641 C CA  . THR B 2 211 ? 229.142 264.532 383.754 1.00 24.26 ? 211 THR B CA  1 
ATOM   2642 C C   . THR B 2 211 ? 230.409 263.709 383.555 1.00 22.47 ? 211 THR B C   1 
ATOM   2643 O O   . THR B 2 211 ? 231.178 263.947 382.620 1.00 20.96 ? 211 THR B O   1 
ATOM   2644 C CB  . THR B 2 211 ? 228.096 264.173 382.697 1.00 22.70 ? 211 THR B CB  1 
ATOM   2645 O OG1 . THR B 2 211 ? 226.911 264.943 382.923 1.00 21.68 ? 211 THR B OG1 1 
ATOM   2646 C CG2 . THR B 2 211 ? 227.745 262.694 382.749 1.00 19.00 ? 211 THR B CG2 1 
ATOM   2647 N N   . LYS B 2 212 ? 230.626 262.739 384.438 1.00 18.67 ? 212 LYS B N   1 
ATOM   2648 C CA  . LYS B 2 212 ? 231.859 261.972 384.422 1.00 19.93 ? 212 LYS B CA  1 
ATOM   2649 C C   . LYS B 2 212 ? 231.778 260.837 383.405 1.00 21.75 ? 212 LYS B C   1 
ATOM   2650 O O   . LYS B 2 212 ? 230.700 260.428 382.969 1.00 21.53 ? 212 LYS B O   1 
ATOM   2651 C CB  . LYS B 2 212 ? 232.160 261.419 385.814 1.00 21.45 ? 212 LYS B CB  1 
ATOM   2652 C CG  . LYS B 2 212 ? 231.285 260.258 386.221 1.00 23.48 ? 212 LYS B CG  1 
ATOM   2653 C CD  . LYS B 2 212 ? 231.147 260.159 387.730 1.00 27.89 ? 212 LYS B CD  1 
ATOM   2654 C CE  . LYS B 2 212 ? 232.490 260.174 388.440 1.00 23.85 ? 212 LYS B CE  1 
ATOM   2655 N NZ  . LYS B 2 212 ? 233.433 259.169 387.893 1.00 25.24 ? 212 LYS B NZ  1 
ATOM   2656 N N   . TYR B 2 213 ? 232.952 260.319 383.039 1.00 20.70 ? 213 TYR B N   1 
ATOM   2657 C CA  . TYR B 2 213 ? 233.033 259.333 381.966 1.00 19.47 ? 213 TYR B CA  1 
ATOM   2658 C C   . TYR B 2 213 ? 232.241 258.075 382.298 1.00 19.41 ? 213 TYR B C   1 
ATOM   2659 O O   . TYR B 2 213 ? 231.562 257.516 381.430 1.00 17.71 ? 213 TYR B O   1 
ATOM   2660 C CB  . TYR B 2 213 ? 234.495 258.989 381.692 1.00 15.43 ? 213 TYR B CB  1 
ATOM   2661 C CG  . TYR B 2 213 ? 234.696 257.955 380.613 1.00 16.11 ? 213 TYR B CG  1 
ATOM   2662 C CD1 . TYR B 2 213 ? 234.691 256.601 380.913 1.00 16.95 ? 213 TYR B CD1 1 
ATOM   2663 C CD2 . TYR B 2 213 ? 234.903 258.331 379.296 1.00 11.90 ? 213 TYR B CD2 1 
ATOM   2664 C CE1 . TYR B 2 213 ? 234.874 255.656 379.935 1.00 13.93 ? 213 TYR B CE1 1 
ATOM   2665 C CE2 . TYR B 2 213 ? 235.088 257.390 378.310 1.00 13.50 ? 213 TYR B CE2 1 
ATOM   2666 C CZ  . TYR B 2 213 ? 235.073 256.054 378.636 1.00 15.17 ? 213 TYR B CZ  1 
ATOM   2667 O OH  . TYR B 2 213 ? 235.257 255.111 377.656 1.00 19.55 ? 213 TYR B OH  1 
ATOM   2668 N N   . GLU B 2 214 ? 232.320 257.606 383.545 1.00 19.74 ? 214 GLU B N   1 
ATOM   2669 C CA  . GLU B 2 214 ? 231.629 256.377 383.917 1.00 19.63 ? 214 GLU B CA  1 
ATOM   2670 C C   . GLU B 2 214 ? 230.114 256.509 383.829 1.00 18.97 ? 214 GLU B C   1 
ATOM   2671 O O   . GLU B 2 214 ? 229.432 255.505 383.604 1.00 22.49 ? 214 GLU B O   1 
ATOM   2672 C CB  . GLU B 2 214 ? 232.028 255.953 385.332 1.00 22.93 ? 214 GLU B CB  1 
ATOM   2673 C CG  . GLU B 2 214 ? 233.499 255.622 385.480 1.00 25.94 ? 214 GLU B CG  1 
ATOM   2674 C CD  . GLU B 2 214 ? 234.270 256.699 386.207 1.00 32.81 ? 214 GLU B CD  1 
ATOM   2675 O OE1 . GLU B 2 214 ? 233.976 256.939 387.395 1.00 34.32 ? 214 GLU B OE1 1 
ATOM   2676 O OE2 . GLU B 2 214 ? 235.162 257.314 385.588 1.00 30.68 ? 214 GLU B OE2 1 
ATOM   2677 N N   . ASN B 2 215 ? 229.573 257.711 384.004 1.00 22.16 ? 215 ASN B N   1 
ATOM   2678 C CA  . ASN B 2 215 ? 228.136 257.920 383.881 1.00 15.51 ? 215 ASN B CA  1 
ATOM   2679 C C   . ASN B 2 215 ? 227.707 258.202 382.450 1.00 17.05 ? 215 ASN B C   1 
ATOM   2680 O O   . ASN B 2 215 ? 226.580 257.867 382.074 1.00 17.58 ? 215 ASN B O   1 
ATOM   2681 C CB  . ASN B 2 215 ? 227.694 259.069 384.787 1.00 18.12 ? 215 ASN B CB  1 
ATOM   2682 C CG  . ASN B 2 215 ? 227.861 258.744 386.251 1.00 24.18 ? 215 ASN B CG  1 
ATOM   2683 O OD1 . ASN B 2 215 ? 227.719 257.593 386.659 1.00 25.58 ? 215 ASN B OD1 1 
ATOM   2684 N ND2 . ASN B 2 215 ? 228.168 259.753 387.052 1.00 21.68 ? 215 ASN B ND2 1 
ATOM   2685 N N   . ALA B 2 216 ? 228.580 258.803 381.644 1.00 20.44 ? 216 ALA B N   1 
ATOM   2686 C CA  . ALA B 2 216 ? 228.270 259.033 380.241 1.00 17.01 ? 216 ALA B CA  1 
ATOM   2687 C C   . ALA B 2 216 ? 228.367 257.763 379.410 1.00 19.04 ? 216 ALA B C   1 
ATOM   2688 O O   . ALA B 2 216 ? 227.860 257.735 378.284 1.00 18.94 ? 216 ALA B O   1 
ATOM   2689 C CB  . ALA B 2 216 ? 229.203 260.099 379.664 1.00 15.09 ? 216 ALA B CB  1 
ATOM   2690 N N   . ASN B 2 217 ? 228.988 256.714 379.943 1.00 17.13 ? 217 ASN B N   1 
ATOM   2691 C CA  . ASN B 2 217 ? 229.160 255.441 379.246 1.00 11.57 ? 217 ASN B CA  1 
ATOM   2692 C C   . ASN B 2 217 ? 228.634 254.328 380.143 1.00 14.92 ? 217 ASN B C   1 
ATOM   2693 O O   . ASN B 2 217 ? 229.408 253.551 380.715 1.00 19.84 ? 217 ASN B O   1 
ATOM   2694 C CB  . ASN B 2 217 ? 230.628 255.213 378.882 1.00 16.15 ? 217 ASN B CB  1 
ATOM   2695 C CG  . ASN B 2 217 ? 231.148 256.228 377.884 1.00 16.06 ? 217 ASN B CG  1 
ATOM   2696 O OD1 . ASN B 2 217 ? 230.995 256.059 376.677 1.00 22.23 ? 217 ASN B OD1 1 
ATOM   2697 N ND2 . ASN B 2 217 ? 231.772 257.285 378.383 1.00 14.47 ? 217 ASN B ND2 1 
ATOM   2698 N N   . PRO B 2 218 ? 227.310 254.223 380.290 1.00 17.75 ? 218 PRO B N   1 
ATOM   2699 C CA  . PRO B 2 218 ? 226.760 253.221 381.214 1.00 18.64 ? 218 PRO B CA  1 
ATOM   2700 C C   . PRO B 2 218 ? 226.849 251.795 380.700 1.00 17.35 ? 218 PRO B C   1 
ATOM   2701 O O   . PRO B 2 218 ? 226.862 250.862 381.510 1.00 19.37 ? 218 PRO B O   1 
ATOM   2702 C CB  . PRO B 2 218 ? 225.303 253.672 381.378 1.00 14.87 ? 218 PRO B CB  1 
ATOM   2703 C CG  . PRO B 2 218 ? 224.985 254.336 380.092 1.00 13.58 ? 218 PRO B CG  1 
ATOM   2704 C CD  . PRO B 2 218 ? 226.249 255.015 379.644 1.00 11.26 ? 218 PRO B CD  1 
ATOM   2705 N N   . GLY B 2 219 ? 226.909 251.594 379.392 1.00 17.68 ? 219 GLY B N   1 
ATOM   2706 C CA  . GLY B 2 219 ? 226.936 250.266 378.821 1.00 11.13 ? 219 GLY B CA  1 
ATOM   2707 C C   . GLY B 2 219 ? 225.577 249.819 378.319 1.00 12.88 ? 219 GLY B C   1 
ATOM   2708 O O   . GLY B 2 219 ? 224.688 250.619 378.021 1.00 18.88 ? 219 GLY B O   1 
ATOM   2709 N N   . GLU B 2 220 ? 225.418 248.497 378.242 1.00 13.07 ? 220 GLU B N   1 
ATOM   2710 C CA  . GLU B 2 220 ? 224.210 247.922 377.661 1.00 9.37  ? 220 GLU B CA  1 
ATOM   2711 C C   . GLU B 2 220 ? 222.959 248.224 378.477 1.00 17.47 ? 220 GLU B C   1 
ATOM   2712 O O   . GLU B 2 220 ? 221.852 248.099 377.948 1.00 17.07 ? 220 GLU B O   1 
ATOM   2713 C CB  . GLU B 2 220 ? 224.370 246.410 377.503 1.00 13.00 ? 220 GLU B CB  1 
ATOM   2714 C CG  . GLU B 2 220 ? 224.648 245.670 378.796 1.00 14.23 ? 220 GLU B CG  1 
ATOM   2715 C CD  . GLU B 2 220 ? 224.488 244.171 378.650 1.00 22.65 ? 220 GLU B CD  1 
ATOM   2716 O OE1 . GLU B 2 220 ? 223.537 243.737 377.968 1.00 25.34 ? 220 GLU B OE1 1 
ATOM   2717 O OE2 . GLU B 2 220 ? 225.317 243.426 379.212 1.00 23.09 ? 220 GLU B OE2 1 
ATOM   2718 N N   . LYS B 2 221 ? 223.100 248.603 379.747 1.00 14.83 ? 221 LYS B N   1 
ATOM   2719 C CA  . LYS B 2 221 ? 221.929 248.994 380.524 1.00 15.22 ? 221 LYS B CA  1 
ATOM   2720 C C   . LYS B 2 221 ? 221.415 250.373 380.130 1.00 14.52 ? 221 LYS B C   1 
ATOM   2721 O O   . LYS B 2 221 ? 220.210 250.628 380.227 1.00 16.40 ? 221 LYS B O   1 
ATOM   2722 C CB  . LYS B 2 221 ? 222.248 248.966 382.019 1.00 12.68 ? 221 LYS B CB  1 
ATOM   2723 C CG  . LYS B 2 221 ? 223.334 249.927 382.451 1.00 18.32 ? 221 LYS B CG  1 
ATOM   2724 C CD  . LYS B 2 221 ? 223.659 249.742 383.922 1.00 25.07 ? 221 LYS B CD  1 
ATOM   2725 C CE  . LYS B 2 221 ? 224.885 250.535 384.337 1.00 19.09 ? 221 LYS B CE  1 
ATOM   2726 N NZ  . LYS B 2 221 ? 224.640 251.998 384.336 1.00 21.28 ? 221 LYS B NZ  1 
ATOM   2727 N N   . GLY B 2 222 ? 222.298 251.268 379.696 1.00 13.11 ? 222 GLY B N   1 
ATOM   2728 C CA  . GLY B 2 222 ? 221.875 252.590 379.293 1.00 9.36  ? 222 GLY B CA  1 
ATOM   2729 C C   . GLY B 2 222 ? 221.353 253.409 380.464 1.00 13.67 ? 222 GLY B C   1 
ATOM   2730 O O   . GLY B 2 222 ? 221.689 253.184 381.627 1.00 18.27 ? 222 GLY B O   1 
ATOM   2731 N N   . GLY B 2 223 ? 220.506 254.382 380.130 1.00 9.45  ? 223 GLY B N   1 
ATOM   2732 C CA  . GLY B 2 223 ? 219.871 255.220 381.125 1.00 4.59  ? 223 GLY B CA  1 
ATOM   2733 C C   . GLY B 2 223 ? 218.418 255.473 380.776 1.00 9.33  ? 223 GLY B C   1 
ATOM   2734 O O   . GLY B 2 223 ? 217.921 255.026 379.743 1.00 13.71 ? 223 GLY B O   1 
ATOM   2735 N N   . GLU B 2 224 ? 217.749 256.207 381.659 1.00 17.36 ? 224 GLU B N   1 
ATOM   2736 C CA  . GLU B 2 224 ? 216.334 256.510 381.520 1.00 9.19  ? 224 GLU B CA  1 
ATOM   2737 C C   . GLU B 2 224 ? 216.109 258.015 381.529 1.00 11.05 ? 224 GLU B C   1 
ATOM   2738 O O   . GLU B 2 224 ? 216.806 258.761 382.221 1.00 18.31 ? 224 GLU B O   1 
ATOM   2739 C CB  . GLU B 2 224 ? 215.518 255.865 382.646 1.00 7.75  ? 224 GLU B CB  1 
ATOM   2740 C CG  . GLU B 2 224 ? 215.496 254.352 382.597 1.00 13.61 ? 224 GLU B CG  1 
ATOM   2741 C CD  . GLU B 2 224 ? 214.827 253.737 383.806 1.00 22.57 ? 224 GLU B CD  1 
ATOM   2742 O OE1 . GLU B 2 224 ? 214.300 254.493 384.646 1.00 25.96 ? 224 GLU B OE1 1 
ATOM   2743 O OE2 . GLU B 2 224 ? 214.828 252.495 383.918 1.00 17.22 ? 224 GLU B OE2 1 
ATOM   2744 N N   . PHE B 2 225 ? 215.128 258.452 380.744 1.00 14.14 ? 225 PHE B N   1 
ATOM   2745 C CA  . PHE B 2 225 ? 214.687 259.837 380.786 1.00 11.49 ? 225 PHE B CA  1 
ATOM   2746 C C   . PHE B 2 225 ? 213.884 260.103 382.053 1.00 13.71 ? 225 PHE B C   1 
ATOM   2747 O O   . PHE B 2 225 ? 213.293 259.196 382.644 1.00 17.62 ? 225 PHE B O   1 
ATOM   2748 C CB  . PHE B 2 225 ? 213.835 260.167 379.561 1.00 9.41  ? 225 PHE B CB  1 
ATOM   2749 C CG  . PHE B 2 225 ? 214.617 260.276 378.288 1.00 12.23 ? 225 PHE B CG  1 
ATOM   2750 C CD1 . PHE B 2 225 ? 215.173 261.484 377.904 1.00 9.66  ? 225 PHE B CD1 1 
ATOM   2751 C CD2 . PHE B 2 225 ? 214.792 259.174 377.472 1.00 5.14  ? 225 PHE B CD2 1 
ATOM   2752 C CE1 . PHE B 2 225 ? 215.890 261.588 376.733 1.00 12.19 ? 225 PHE B CE1 1 
ATOM   2753 C CE2 . PHE B 2 225 ? 215.507 259.272 376.300 1.00 7.86  ? 225 PHE B CE2 1 
ATOM   2754 C CZ  . PHE B 2 225 ? 216.060 260.482 375.931 1.00 10.22 ? 225 PHE B CZ  1 
ATOM   2755 N N   . LYS B 2 226 ? 213.870 261.363 382.471 1.00 12.96 ? 226 LYS B N   1 
ATOM   2756 C CA  . LYS B 2 226 ? 213.066 261.816 383.594 1.00 13.36 ? 226 LYS B CA  1 
ATOM   2757 C C   . LYS B 2 226 ? 211.923 262.688 383.091 1.00 16.63 ? 226 LYS B C   1 
ATOM   2758 O O   . LYS B 2 226 ? 211.968 263.239 381.989 1.00 11.56 ? 226 LYS B O   1 
ATOM   2759 C CB  . LYS B 2 226 ? 213.906 262.607 384.602 1.00 15.75 ? 226 LYS B CB  1 
ATOM   2760 C CG  . LYS B 2 226 ? 215.257 261.996 384.928 1.00 17.58 ? 226 LYS B CG  1 
ATOM   2761 C CD  . LYS B 2 226 ? 215.126 260.637 385.586 1.00 20.20 ? 226 LYS B CD  1 
ATOM   2762 C CE  . LYS B 2 226 ? 216.488 260.052 385.917 1.00 19.51 ? 226 LYS B CE  1 
ATOM   2763 N NZ  . LYS B 2 226 ? 217.371 259.965 384.721 1.00 18.93 ? 226 LYS B NZ  1 
ATOM   2764 N N   . GLY B 2 227 ? 210.886 262.806 383.922 1.00 19.19 ? 227 GLY B N   1 
ATOM   2765 C CA  . GLY B 2 227 ? 209.776 263.681 383.600 1.00 17.03 ? 227 GLY B CA  1 
ATOM   2766 C C   . GLY B 2 227 ? 210.036 265.147 383.864 1.00 16.79 ? 227 GLY B C   1 
ATOM   2767 O O   . GLY B 2 227 ? 209.412 265.998 383.224 1.00 21.20 ? 227 GLY B O   1 
ATOM   2768 N N   . SER B 2 228 ? 210.947 265.463 384.782 1.00 18.37 ? 228 SER B N   1 
ATOM   2769 C CA  . SER B 2 228 ? 211.255 266.845 385.119 1.00 20.67 ? 228 SER B CA  1 
ATOM   2770 C C   . SER B 2 228 ? 212.740 266.955 385.434 1.00 21.65 ? 228 SER B C   1 
ATOM   2771 O O   . SER B 2 228 ? 213.444 265.953 385.573 1.00 25.75 ? 228 SER B O   1 
ATOM   2772 C CB  . SER B 2 228 ? 210.415 267.338 386.301 1.00 22.86 ? 228 SER B CB  1 
ATOM   2773 O OG  . SER B 2 228 ? 210.837 266.738 387.511 1.00 23.82 ? 228 SER B OG  1 
ATOM   2774 N N   . PHE B 2 229 ? 213.213 268.193 385.546 1.00 20.84 ? 229 PHE B N   1 
ATOM   2775 C CA  . PHE B 2 229 ? 214.623 268.460 385.790 1.00 21.82 ? 229 PHE B CA  1 
ATOM   2776 C C   . PHE B 2 229 ? 214.879 268.616 387.282 1.00 22.63 ? 229 PHE B C   1 
ATOM   2777 O O   . PHE B 2 229 ? 214.233 269.427 387.951 1.00 27.38 ? 229 PHE B O   1 
ATOM   2778 C CB  . PHE B 2 229 ? 215.075 269.716 385.048 1.00 21.27 ? 229 PHE B CB  1 
ATOM   2779 C CG  . PHE B 2 229 ? 216.529 270.033 385.235 1.00 22.48 ? 229 PHE B CG  1 
ATOM   2780 C CD1 . PHE B 2 229 ? 217.501 269.273 384.609 1.00 24.74 ? 229 PHE B CD1 1 
ATOM   2781 C CD2 . PHE B 2 229 ? 216.925 271.086 386.038 1.00 18.31 ? 229 PHE B CD2 1 
ATOM   2782 C CE1 . PHE B 2 229 ? 218.839 269.558 384.782 1.00 22.05 ? 229 PHE B CE1 1 
ATOM   2783 C CE2 . PHE B 2 229 ? 218.263 271.376 386.212 1.00 21.24 ? 229 PHE B CE2 1 
ATOM   2784 C CZ  . PHE B 2 229 ? 219.220 270.610 385.584 1.00 20.49 ? 229 PHE B CZ  1 
ATOM   2785 N N   . THR B 2 230 ? 215.825 267.838 387.795 1.00 25.14 ? 230 THR B N   1 
ATOM   2786 C CA  . THR B 2 230 ? 216.273 267.941 389.176 1.00 28.88 ? 230 THR B CA  1 
ATOM   2787 C C   . THR B 2 230 ? 217.734 268.356 389.182 1.00 27.83 ? 230 THR B C   1 
ATOM   2788 O O   . THR B 2 230 ? 218.553 267.772 388.465 1.00 28.70 ? 230 THR B O   1 
ATOM   2789 C CB  . THR B 2 230 ? 216.098 266.616 389.921 1.00 28.29 ? 230 THR B CB  1 
ATOM   2790 O OG1 . THR B 2 230 ? 214.719 266.229 389.900 1.00 27.16 ? 230 THR B OG1 1 
ATOM   2791 C CG2 . THR B 2 230 ? 216.563 266.751 391.362 1.00 26.37 ? 230 THR B CG2 1 
ATOM   2792 N N   . LEU B 2 231 ? 218.056 269.362 389.987 1.00 31.20 ? 231 LEU B N   1 
ATOM   2793 C CA  . LEU B 2 231 ? 219.416 269.868 390.086 1.00 32.38 ? 231 LEU B CA  1 
ATOM   2794 C C   . LEU B 2 231 ? 220.127 269.193 391.251 1.00 32.18 ? 231 LEU B C   1 
ATOM   2795 O O   . LEU B 2 231 ? 219.652 269.244 392.389 1.00 35.91 ? 231 LEU B O   1 
ATOM   2796 C CB  . LEU B 2 231 ? 219.408 271.384 390.275 1.00 30.77 ? 231 LEU B CB  1 
ATOM   2797 C CG  . LEU B 2 231 ? 220.747 272.102 390.118 1.00 32.55 ? 231 LEU B CG  1 
ATOM   2798 C CD1 . LEU B 2 231 ? 221.234 272.034 388.678 1.00 30.92 ? 231 LEU B CD1 1 
ATOM   2799 C CD2 . LEU B 2 231 ? 220.613 273.544 390.572 1.00 31.31 ? 231 LEU B CD2 1 
ATOM   2800 N N   . ASP B 2 232 ? 221.258 268.559 390.963 1.00 35.88 ? 232 ASP B N   1 
ATOM   2801 C CA  . ASP B 2 232 ? 222.047 267.930 392.012 1.00 35.32 ? 232 ASP B CA  1 
ATOM   2802 C C   . ASP B 2 232 ? 222.708 268.997 392.873 1.00 38.53 ? 232 ASP B C   1 
ATOM   2803 O O   . ASP B 2 232 ? 223.453 269.844 392.370 1.00 38.82 ? 232 ASP B O   1 
ATOM   2804 C CB  . ASP B 2 232 ? 223.098 267.007 391.399 1.00 32.36 ? 232 ASP B CB  1 
ATOM   2805 C CG  . ASP B 2 232 ? 223.971 266.346 392.441 1.00 38.31 ? 232 ASP B CG  1 
ATOM   2806 O OD1 . ASP B 2 232 ? 223.432 265.596 393.279 1.00 40.01 ? 232 ASP B OD1 1 
ATOM   2807 O OD2 . ASP B 2 232 ? 225.199 266.571 392.420 1.00 40.36 ? 232 ASP B OD2 1 
ATOM   2808 N N   . THR B 2 233 ? 222.434 268.956 394.178 1.00 41.46 ? 233 THR B N   1 
ATOM   2809 C CA  . THR B 2 233 ? 222.945 269.955 395.104 1.00 43.93 ? 233 THR B CA  1 
ATOM   2810 C C   . THR B 2 233 ? 224.107 269.469 395.957 1.00 45.03 ? 233 THR B C   1 
ATOM   2811 O O   . THR B 2 233 ? 224.789 270.299 396.565 1.00 44.80 ? 233 THR B O   1 
ATOM   2812 C CB  . THR B 2 233 ? 221.826 270.441 396.037 1.00 44.68 ? 233 THR B CB  1 
ATOM   2813 O OG1 . THR B 2 233 ? 221.239 269.321 396.710 1.00 45.31 ? 233 THR B OG1 1 
ATOM   2814 C CG2 . THR B 2 233 ? 220.754 271.175 395.250 1.00 43.40 ? 233 THR B CG2 1 
ATOM   2815 N N   . ASN B 2 234 ? 224.352 268.160 396.020 1.00 44.26 ? 234 ASN B N   1 
ATOM   2816 C CA  . ASN B 2 234 ? 225.462 267.645 396.810 1.00 43.71 ? 234 ASN B CA  1 
ATOM   2817 C C   . ASN B 2 234 ? 226.778 268.173 396.253 1.00 44.87 ? 234 ASN B C   1 
ATOM   2818 O O   . ASN B 2 234 ? 227.202 267.776 395.163 1.00 43.60 ? 234 ASN B O   1 
ATOM   2819 C CB  . ASN B 2 234 ? 225.454 266.116 396.816 1.00 43.66 ? 234 ASN B CB  1 
ATOM   2820 C CG  . ASN B 2 234 ? 226.429 265.529 397.820 1.00 45.09 ? 234 ASN B CG  1 
ATOM   2821 O OD1 . ASN B 2 234 ? 227.460 266.127 398.127 1.00 44.74 ? 234 ASN B OD1 1 
ATOM   2822 N ND2 . ASN B 2 234 ? 226.105 264.350 398.337 1.00 44.91 ? 234 ASN B ND2 1 
ATOM   2823 N N   . ALA B 2 235 ? 227.431 269.066 396.997 1.00 47.36 ? 235 ALA B N   1 
ATOM   2824 C CA  . ALA B 2 235 ? 228.671 269.681 396.543 1.00 46.93 ? 235 ALA B CA  1 
ATOM   2825 C C   . ALA B 2 235 ? 229.904 268.903 396.973 1.00 48.07 ? 235 ALA B C   1 
ATOM   2826 O O   . ALA B 2 235 ? 230.890 268.857 396.227 1.00 48.13 ? 235 ALA B O   1 
ATOM   2827 C CB  . ALA B 2 235 ? 228.770 271.114 397.069 1.00 46.49 ? 235 ALA B CB  1 
ATOM   2828 N N   . THR B 2 236 ? 229.879 268.304 398.164 1.00 48.84 ? 236 THR B N   1 
ATOM   2829 C CA  . THR B 2 236 ? 231.010 267.499 398.611 1.00 49.32 ? 236 THR B CA  1 
ATOM   2830 C C   . THR B 2 236 ? 231.187 266.271 397.726 1.00 47.77 ? 236 THR B C   1 
ATOM   2831 O O   . THR B 2 236 ? 232.311 265.919 397.351 1.00 47.47 ? 236 THR B O   1 
ATOM   2832 C CB  . THR B 2 236 ? 230.810 267.085 400.070 1.00 50.47 ? 236 THR B CB  1 
ATOM   2833 O OG1 . THR B 2 236 ? 230.291 268.193 400.815 1.00 51.37 ? 236 THR B OG1 1 
ATOM   2834 C CG2 . THR B 2 236 ? 232.128 266.644 400.686 1.00 48.47 ? 236 THR B CG2 1 
ATOM   2835 N N   . ASN B 2 237 ? 230.085 265.608 397.380 1.00 43.65 ? 237 ASN B N   1 
ATOM   2836 C CA  . ASN B 2 237 ? 230.096 264.404 396.550 1.00 43.24 ? 237 ASN B CA  1 
ATOM   2837 C C   . ASN B 2 237 ? 229.059 264.566 395.448 1.00 42.73 ? 237 ASN B C   1 
ATOM   2838 O O   . ASN B 2 237 ? 227.958 264.007 395.527 1.00 41.71 ? 237 ASN B O   1 
ATOM   2839 C CB  . ASN B 2 237 ? 229.820 263.157 397.390 1.00 45.03 ? 237 ASN B CB  1 
ATOM   2840 C CG  . ASN B 2 237 ? 229.660 261.906 396.547 1.00 45.97 ? 237 ASN B CG  1 
ATOM   2841 O OD1 . ASN B 2 237 ? 230.028 261.882 395.373 1.00 47.62 ? 237 ASN B OD1 1 
ATOM   2842 N ND2 . ASN B 2 237 ? 229.112 260.857 397.147 1.00 44.35 ? 237 ASN B ND2 1 
ATOM   2843 N N   . PRO B 2 238 ? 229.371 265.334 394.407 1.00 40.58 ? 238 PRO B N   1 
ATOM   2844 C CA  . PRO B 2 238 ? 228.420 265.495 393.303 1.00 37.58 ? 238 PRO B CA  1 
ATOM   2845 C C   . PRO B 2 238 ? 228.218 264.196 392.537 1.00 35.23 ? 238 PRO B C   1 
ATOM   2846 O O   . PRO B 2 238 ? 229.110 263.352 392.435 1.00 35.50 ? 238 PRO B O   1 
ATOM   2847 C CB  . PRO B 2 238 ? 229.070 266.568 392.424 1.00 36.33 ? 238 PRO B CB  1 
ATOM   2848 C CG  . PRO B 2 238 ? 230.516 266.499 392.746 1.00 39.04 ? 238 PRO B CG  1 
ATOM   2849 C CD  . PRO B 2 238 ? 230.608 266.102 394.188 1.00 37.71 ? 238 PRO B CD  1 
ATOM   2850 N N   . ALA B 2 239 ? 227.010 264.045 391.992 1.00 35.68 ? 239 ALA B N   1 
ATOM   2851 C CA  . ALA B 2 239 ? 226.678 262.845 391.233 1.00 32.11 ? 239 ALA B CA  1 
ATOM   2852 C C   . ALA B 2 239 ? 227.299 262.854 389.843 1.00 29.04 ? 239 ALA B C   1 
ATOM   2853 O O   . ALA B 2 239 ? 227.694 261.797 389.341 1.00 30.87 ? 239 ALA B O   1 
ATOM   2854 C CB  . ALA B 2 239 ? 225.161 262.696 391.128 1.00 30.67 ? 239 ALA B CB  1 
ATOM   2855 N N   . ARG B 2 240 ? 227.390 264.023 389.211 1.00 28.40 ? 240 ARG B N   1 
ATOM   2856 C CA  . ARG B 2 240 ? 228.007 264.158 387.892 1.00 28.94 ? 240 ARG B CA  1 
ATOM   2857 C C   . ARG B 2 240 ? 227.383 263.196 386.884 1.00 24.99 ? 240 ARG B C   1 
ATOM   2858 O O   . ARG B 2 240 ? 228.077 262.535 386.110 1.00 25.35 ? 240 ARG B O   1 
ATOM   2859 C CB  . ARG B 2 240 ? 229.518 263.949 387.981 1.00 26.91 ? 240 ARG B CB  1 
ATOM   2860 C CG  . ARG B 2 240 ? 230.205 264.888 388.956 1.00 25.24 ? 240 ARG B CG  1 
ATOM   2861 C CD  . ARG B 2 240 ? 231.713 264.789 388.863 1.00 27.12 ? 240 ARG B CD  1 
ATOM   2862 N NE  . ARG B 2 240 ? 232.194 265.099 387.523 1.00 28.14 ? 240 ARG B NE  1 
ATOM   2863 C CZ  . ARG B 2 240 ? 233.462 265.026 387.145 1.00 28.30 ? 240 ARG B CZ  1 
ATOM   2864 N NH1 . ARG B 2 240 ? 234.415 264.666 387.987 1.00 29.80 ? 240 ARG B NH1 1 
ATOM   2865 N NH2 . ARG B 2 240 ? 233.782 265.319 385.889 1.00 26.59 ? 240 ARG B NH2 1 
ATOM   2866 N N   . ASN B 2 241 ? 226.057 263.127 386.888 1.00 23.31 ? 241 ASN B N   1 
ATOM   2867 C CA  . ASN B 2 241 ? 225.302 262.246 386.013 1.00 20.73 ? 241 ASN B CA  1 
ATOM   2868 C C   . ASN B 2 241 ? 224.419 263.063 385.077 1.00 22.23 ? 241 ASN B C   1 
ATOM   2869 O O   . ASN B 2 241 ? 224.183 264.254 385.291 1.00 23.26 ? 241 ASN B O   1 
ATOM   2870 C CB  . ASN B 2 241 ? 224.446 261.277 386.839 1.00 23.44 ? 241 ASN B CB  1 
ATOM   2871 C CG  . ASN B 2 241 ? 223.909 260.124 386.018 1.00 26.89 ? 241 ASN B CG  1 
ATOM   2872 O OD1 . ASN B 2 241 ? 224.411 259.827 384.935 1.00 26.84 ? 241 ASN B OD1 1 
ATOM   2873 N ND2 . ASN B 2 241 ? 222.881 259.465 386.533 1.00 31.22 ? 241 ASN B ND2 1 
ATOM   2874 N N   . PHE B 2 242 ? 223.945 262.411 384.018 1.00 18.82 ? 242 PHE B N   1 
ATOM   2875 C CA  . PHE B 2 242 ? 222.988 263.039 383.118 1.00 16.42 ? 242 PHE B CA  1 
ATOM   2876 C C   . PHE B 2 242 ? 221.643 263.230 383.810 1.00 16.62 ? 242 PHE B C   1 
ATOM   2877 O O   . PHE B 2 242 ? 221.247 262.435 384.666 1.00 23.28 ? 242 PHE B O   1 
ATOM   2878 C CB  . PHE B 2 242 ? 222.792 262.188 381.862 1.00 16.27 ? 242 PHE B CB  1 
ATOM   2879 C CG  . PHE B 2 242 ? 223.948 262.223 380.903 1.00 17.39 ? 242 PHE B CG  1 
ATOM   2880 C CD1 . PHE B 2 242 ? 224.602 263.408 380.615 1.00 17.24 ? 242 PHE B CD1 1 
ATOM   2881 C CD2 . PHE B 2 242 ? 224.372 261.064 380.279 1.00 15.66 ? 242 PHE B CD2 1 
ATOM   2882 C CE1 . PHE B 2 242 ? 225.657 263.433 379.729 1.00 13.68 ? 242 PHE B CE1 1 
ATOM   2883 C CE2 . PHE B 2 242 ? 225.425 261.086 379.390 1.00 15.01 ? 242 PHE B CE2 1 
ATOM   2884 C CZ  . PHE B 2 242 ? 226.068 262.272 379.116 1.00 12.87 ? 242 PHE B CZ  1 
ATOM   2885 N N   . CYS B 2 243 ? 220.932 264.291 383.423 1.00 14.98 ? 243 CYS B N   1 
ATOM   2886 C CA  . CYS B 2 243 ? 219.551 264.531 383.840 1.00 20.95 ? 243 CYS B CA  1 
ATOM   2887 C C   . CYS B 2 243 ? 218.727 264.834 382.593 1.00 19.51 ? 243 CYS B C   1 
ATOM   2888 O O   . CYS B 2 243 ? 218.299 265.978 382.381 1.00 18.23 ? 243 CYS B O   1 
ATOM   2889 C CB  . CYS B 2 243 ? 219.455 265.672 384.849 1.00 20.37 ? 243 CYS B CB  1 
ATOM   2890 S SG  . CYS B 2 243 ? 217.787 265.931 385.492 1.00 31.87 ? 243 CYS B SG  1 
ATOM   2891 N N   . PRO B 2 244 ? 218.482 263.835 381.748 1.00 17.53 ? 244 PRO B N   1 
ATOM   2892 C CA  . PRO B 2 244 ? 217.774 264.094 380.488 1.00 14.67 ? 244 PRO B CA  1 
ATOM   2893 C C   . PRO B 2 244 ? 216.261 264.150 380.648 1.00 11.09 ? 244 PRO B C   1 
ATOM   2894 O O   . PRO B 2 244 ? 215.631 263.159 381.023 1.00 13.46 ? 244 PRO B O   1 
ATOM   2895 C CB  . PRO B 2 244 ? 218.207 262.916 379.609 1.00 18.82 ? 244 PRO B CB  1 
ATOM   2896 C CG  . PRO B 2 244 ? 218.453 261.806 380.579 1.00 12.44 ? 244 PRO B CG  1 
ATOM   2897 C CD  . PRO B 2 244 ? 218.899 262.429 381.872 1.00 7.70  ? 244 PRO B CD  1 
ATOM   2898 N N   . VAL B 2 245 ? 215.674 265.308 380.365 1.00 10.57 ? 245 VAL B N   1 
ATOM   2899 C CA  . VAL B 2 245 ? 214.231 265.493 380.479 1.00 10.71 ? 245 VAL B CA  1 
ATOM   2900 C C   . VAL B 2 245 ? 213.573 265.069 379.173 1.00 10.61 ? 245 VAL B C   1 
ATOM   2901 O O   . VAL B 2 245 ? 214.007 265.469 378.088 1.00 8.44  ? 245 VAL B O   1 
ATOM   2902 C CB  . VAL B 2 245 ? 213.899 266.952 380.828 1.00 11.86 ? 245 VAL B CB  1 
ATOM   2903 C CG1 . VAL B 2 245 ? 212.395 267.154 380.917 1.00 13.91 ? 245 VAL B CG1 1 
ATOM   2904 C CG2 . VAL B 2 245 ? 214.571 267.346 382.132 1.00 14.76 ? 245 VAL B CG2 1 
ATOM   2905 N N   . ASP B 2 246 ? 212.523 264.253 379.278 1.00 11.66 ? 246 ASP B N   1 
ATOM   2906 C CA  . ASP B 2 246 ? 211.945 263.619 378.095 1.00 14.45 ? 246 ASP B CA  1 
ATOM   2907 C C   . ASP B 2 246 ? 211.412 264.648 377.103 1.00 11.79 ? 246 ASP B C   1 
ATOM   2908 O O   . ASP B 2 246 ? 211.705 264.573 375.905 1.00 10.07 ? 246 ASP B O   1 
ATOM   2909 C CB  . ASP B 2 246 ? 210.837 262.648 378.508 1.00 5.64  ? 246 ASP B CB  1 
ATOM   2910 C CG  . ASP B 2 246 ? 209.796 263.291 379.403 1.00 13.54 ? 246 ASP B CG  1 
ATOM   2911 O OD1 . ASP B 2 246 ? 209.934 264.488 379.726 1.00 11.61 ? 246 ASP B OD1 1 
ATOM   2912 O OD2 . ASP B 2 246 ? 208.840 262.592 379.788 1.00 16.84 ? 246 ASP B OD2 1 
ATOM   2913 N N   . TYR B 2 247 ? 210.620 265.616 377.574 1.00 8.09  ? 247 TYR B N   1 
ATOM   2914 C CA  . TYR B 2 247 ? 210.021 266.565 376.643 1.00 5.97  ? 247 TYR B CA  1 
ATOM   2915 C C   . TYR B 2 247 ? 211.046 267.548 376.095 1.00 7.44  ? 247 TYR B C   1 
ATOM   2916 O O   . TYR B 2 247 ? 210.809 268.148 375.043 1.00 8.41  ? 247 TYR B O   1 
ATOM   2917 C CB  . TYR B 2 247 ? 208.849 267.307 377.303 1.00 8.65  ? 247 TYR B CB  1 
ATOM   2918 C CG  . TYR B 2 247 ? 209.228 268.422 378.252 1.00 10.57 ? 247 TYR B CG  1 
ATOM   2919 C CD1 . TYR B 2 247 ? 209.399 269.719 377.795 1.00 5.42  ? 247 TYR B CD1 1 
ATOM   2920 C CD2 . TYR B 2 247 ? 209.392 268.182 379.606 1.00 10.01 ? 247 TYR B CD2 1 
ATOM   2921 C CE1 . TYR B 2 247 ? 209.735 270.739 378.655 1.00 6.07  ? 247 TYR B CE1 1 
ATOM   2922 C CE2 . TYR B 2 247 ? 209.728 269.196 380.473 1.00 7.98  ? 247 TYR B CE2 1 
ATOM   2923 C CZ  . TYR B 2 247 ? 209.899 270.473 379.991 1.00 6.32  ? 247 TYR B CZ  1 
ATOM   2924 O OH  . TYR B 2 247 ? 210.235 271.487 380.850 1.00 13.52 ? 247 TYR B OH  1 
ATOM   2925 N N   . LEU B 2 248 ? 212.180 267.709 376.769 1.00 9.35  ? 248 LEU B N   1 
ATOM   2926 C CA  . LEU B 2 248 ? 213.324 268.413 376.211 1.00 9.76  ? 248 LEU B CA  1 
ATOM   2927 C C   . LEU B 2 248 ? 214.266 267.475 375.470 1.00 4.65  ? 248 LEU B C   1 
ATOM   2928 O O   . LEU B 2 248 ? 215.325 267.912 375.012 1.00 10.39 ? 248 LEU B O   1 
ATOM   2929 C CB  . LEU B 2 248 ? 214.079 269.155 377.315 1.00 9.16  ? 248 LEU B CB  1 
ATOM   2930 C CG  . LEU B 2 248 ? 213.270 270.233 378.042 1.00 9.02  ? 248 LEU B CG  1 
ATOM   2931 C CD1 . LEU B 2 248 ? 214.104 270.906 379.112 1.00 9.72  ? 248 LEU B CD1 1 
ATOM   2932 C CD2 . LEU B 2 248 ? 212.736 271.260 377.063 1.00 8.88  ? 248 LEU B CD2 1 
ATOM   2933 N N   . PHE B 2 249 ? 213.900 266.198 375.344 1.00 9.82  ? 249 PHE B N   1 
ATOM   2934 C CA  . PHE B 2 249 ? 214.697 265.204 374.628 1.00 7.19  ? 249 PHE B CA  1 
ATOM   2935 C C   . PHE B 2 249 ? 216.107 265.108 375.202 1.00 5.68  ? 249 PHE B C   1 
ATOM   2936 O O   . PHE B 2 249 ? 217.049 264.707 374.518 1.00 12.46 ? 249 PHE B O   1 
ATOM   2937 C CB  . PHE B 2 249 ? 214.733 265.514 373.130 1.00 6.01  ? 249 PHE B CB  1 
ATOM   2938 C CG  . PHE B 2 249 ? 215.018 264.318 372.264 1.00 8.83  ? 249 PHE B CG  1 
ATOM   2939 C CD1 . PHE B 2 249 ? 214.230 263.182 372.342 1.00 10.32 ? 249 PHE B CD1 1 
ATOM   2940 C CD2 . PHE B 2 249 ? 216.061 264.337 371.357 1.00 6.91  ? 249 PHE B CD2 1 
ATOM   2941 C CE1 . PHE B 2 249 ? 214.487 262.086 371.544 1.00 10.19 ? 249 PHE B CE1 1 
ATOM   2942 C CE2 . PHE B 2 249 ? 216.319 263.242 370.557 1.00 10.44 ? 249 PHE B CE2 1 
ATOM   2943 C CZ  . PHE B 2 249 ? 215.530 262.117 370.650 1.00 5.88  ? 249 PHE B CZ  1 
ATOM   2944 N N   . GLY B 2 250 ? 216.258 265.494 376.466 1.00 8.91  ? 250 GLY B N   1 
ATOM   2945 C CA  . GLY B 2 250 ? 217.513 265.390 377.173 1.00 13.11 ? 250 GLY B CA  1 
ATOM   2946 C C   . GLY B 2 250 ? 218.598 266.348 376.736 1.00 14.48 ? 250 GLY B C   1 
ATOM   2947 O O   . GLY B 2 250 ? 219.707 266.273 377.273 1.00 15.31 ? 250 GLY B O   1 
ATOM   2948 N N   . SER B 2 251 ? 218.323 267.253 375.788 1.00 10.47 ? 251 SER B N   1 
ATOM   2949 C CA  . SER B 2 251 ? 219.360 268.140 375.275 1.00 9.63  ? 251 SER B CA  1 
ATOM   2950 C C   . SER B 2 251 ? 218.864 269.563 375.031 1.00 13.93 ? 251 SER B C   1 
ATOM   2951 O O   . SER B 2 251 ? 219.511 270.310 374.291 1.00 16.78 ? 251 SER B O   1 
ATOM   2952 C CB  . SER B 2 251 ? 219.945 267.581 373.977 1.00 15.78 ? 251 SER B CB  1 
ATOM   2953 O OG  . SER B 2 251 ? 218.942 267.409 372.995 1.00 16.82 ? 251 SER B OG  1 
ATOM   2954 N N   . GLY B 2 252 ? 217.744 269.962 375.627 1.00 17.10 ? 252 GLY B N   1 
ATOM   2955 C CA  . GLY B 2 252 ? 217.257 271.318 375.465 1.00 1.54  ? 252 GLY B CA  1 
ATOM   2956 C C   . GLY B 2 252 ? 216.541 271.600 374.165 1.00 3.79  ? 252 GLY B C   1 
ATOM   2957 O O   . GLY B 2 252 ? 216.503 272.755 373.734 1.00 10.88 ? 252 GLY B O   1 
ATOM   2958 N N   . VAL B 2 253 ? 215.979 270.581 373.518 1.00 10.96 ? 253 VAL B N   1 
ATOM   2959 C CA  . VAL B 2 253 ? 215.181 270.738 372.310 1.00 7.95  ? 253 VAL B CA  1 
ATOM   2960 C C   . VAL B 2 253 ? 213.848 270.037 372.540 1.00 9.06  ? 253 VAL B C   1 
ATOM   2961 O O   . VAL B 2 253 ? 213.730 269.146 373.377 1.00 18.94 ? 253 VAL B O   1 
ATOM   2962 C CB  . VAL B 2 253 ? 215.886 270.168 371.060 1.00 9.94  ? 253 VAL B CB  1 
ATOM   2963 C CG1 . VAL B 2 253 ? 217.224 270.853 370.838 1.00 6.43  ? 253 VAL B CG1 1 
ATOM   2964 C CG2 . VAL B 2 253 ? 216.062 268.662 371.190 1.00 9.05  ? 253 VAL B CG2 1 
ATOM   2965 N N   . LEU B 2 254 ? 212.834 270.445 371.789 1.00 11.73 ? 254 LEU B N   1 
ATOM   2966 C CA  . LEU B 2 254 ? 211.499 269.879 371.948 1.00 9.32  ? 254 LEU B CA  1 
ATOM   2967 C C   . LEU B 2 254 ? 211.467 268.477 371.352 1.00 10.42 ? 254 LEU B C   1 
ATOM   2968 O O   . LEU B 2 254 ? 211.882 268.272 370.207 1.00 10.22 ? 254 LEU B O   1 
ATOM   2969 C CB  . LEU B 2 254 ? 210.446 270.773 371.297 1.00 4.74  ? 254 LEU B CB  1 
ATOM   2970 C CG  . LEU B 2 254 ? 210.186 272.107 372.000 1.00 5.59  ? 254 LEU B CG  1 
ATOM   2971 C CD1 . LEU B 2 254 ? 209.024 272.825 371.344 1.00 6.81  ? 254 LEU B CD1 1 
ATOM   2972 C CD2 . LEU B 2 254 ? 209.926 271.920 373.483 1.00 7.90  ? 254 LEU B CD2 1 
ATOM   2973 N N   . ALA B 2 255 ? 210.976 267.515 372.138 1.00 8.92  ? 255 ALA B N   1 
ATOM   2974 C CA  . ALA B 2 255 ? 210.943 266.127 371.691 1.00 6.65  ? 255 ALA B CA  1 
ATOM   2975 C C   . ALA B 2 255 ? 210.076 265.954 370.451 1.00 8.80  ? 255 ALA B C   1 
ATOM   2976 O O   . ALA B 2 255 ? 210.331 265.061 369.637 1.00 8.86  ? 255 ALA B O   1 
ATOM   2977 C CB  . ALA B 2 255 ? 210.438 265.229 372.818 1.00 3.47  ? 255 ALA B CB  1 
ATOM   2978 N N   . GLY B 2 256 ? 209.056 266.798 370.285 1.00 7.75  ? 256 GLY B N   1 
ATOM   2979 C CA  . GLY B 2 256 ? 208.209 266.717 369.110 1.00 1.70  ? 256 GLY B CA  1 
ATOM   2980 C C   . GLY B 2 256 ? 208.956 266.879 367.805 1.00 1.23  ? 256 GLY B C   1 
ATOM   2981 O O   . GLY B 2 256 ? 208.508 266.369 366.777 1.00 6.76  ? 256 GLY B O   1 
ATOM   2982 N N   . ASN B 2 257 ? 210.085 267.581 367.819 1.00 9.48  ? 257 ASN B N   1 
ATOM   2983 C CA  . ASN B 2 257 ? 210.899 267.768 366.627 1.00 4.50  ? 257 ASN B CA  1 
ATOM   2984 C C   . ASN B 2 257 ? 211.988 266.714 366.486 1.00 7.37  ? 257 ASN B C   1 
ATOM   2985 O O   . ASN B 2 257 ? 212.701 266.706 365.475 1.00 13.56 ? 257 ASN B O   1 
ATOM   2986 C CB  . ASN B 2 257 ? 211.515 269.168 366.637 1.00 5.14  ? 257 ASN B CB  1 
ATOM   2987 C CG  . ASN B 2 257 ? 210.465 270.259 366.675 1.00 3.33  ? 257 ASN B CG  1 
ATOM   2988 O OD1 . ASN B 2 257 ? 209.366 270.090 366.153 1.00 18.10 ? 257 ASN B OD1 1 
ATOM   2989 N ND2 . ASN B 2 257 ? 210.793 271.377 367.302 1.00 7.94  ? 257 ASN B ND2 1 
ATOM   2990 N N   . ALA B 2 258 ? 212.103 265.795 367.448 1.00 7.31  ? 258 ALA B N   1 
ATOM   2991 C CA  . ALA B 2 258 ? 213.102 264.741 367.345 1.00 6.57  ? 258 ALA B CA  1 
ATOM   2992 C C   . ALA B 2 258 ? 212.908 263.909 366.090 1.00 4.04  ? 258 ALA B C   1 
ATOM   2993 O O   . ALA B 2 258 ? 213.851 263.254 365.641 1.00 7.39  ? 258 ALA B O   1 
ATOM   2994 C CB  . ALA B 2 258 ? 213.054 263.842 368.581 1.00 8.95  ? 258 ALA B CB  1 
ATOM   2995 N N   . PHE B 2 259 ? 211.713 263.938 365.507 1.00 6.48  ? 259 PHE B N   1 
ATOM   2996 C CA  . PHE B 2 259 ? 211.431 263.230 364.268 1.00 7.93  ? 259 PHE B CA  1 
ATOM   2997 C C   . PHE B 2 259 ? 212.247 263.738 363.086 1.00 2.77  ? 259 PHE B C   1 
ATOM   2998 O O   . PHE B 2 259 ? 212.123 263.170 361.999 1.00 10.30 ? 259 PHE B O   1 
ATOM   2999 C CB  . PHE B 2 259 ? 209.936 263.325 363.957 1.00 3.68  ? 259 PHE B CB  1 
ATOM   3000 C CG  . PHE B 2 259 ? 209.072 262.593 364.942 1.00 11.00 ? 259 PHE B CG  1 
ATOM   3001 C CD1 . PHE B 2 259 ? 208.643 263.210 366.102 1.00 1.26  ? 259 PHE B CD1 1 
ATOM   3002 C CD2 . PHE B 2 259 ? 208.702 261.278 364.715 1.00 2.83  ? 259 PHE B CD2 1 
ATOM   3003 C CE1 . PHE B 2 259 ? 207.860 262.534 367.011 1.00 5.37  ? 259 PHE B CE1 1 
ATOM   3004 C CE2 . PHE B 2 259 ? 207.919 260.603 365.621 1.00 0.29  ? 259 PHE B CE2 1 
ATOM   3005 C CZ  . PHE B 2 259 ? 207.500 261.231 366.769 1.00 1.07  ? 259 PHE B CZ  1 
ATOM   3006 N N   . VAL B 2 260 ? 213.068 264.779 363.249 1.00 5.95  ? 260 VAL B N   1 
ATOM   3007 C CA  . VAL B 2 260 ? 214.017 265.111 362.189 1.00 5.34  ? 260 VAL B CA  1 
ATOM   3008 C C   . VAL B 2 260 ? 215.179 264.125 362.151 1.00 3.77  ? 260 VAL B C   1 
ATOM   3009 O O   . VAL B 2 260 ? 215.870 264.033 361.130 1.00 3.02  ? 260 VAL B O   1 
ATOM   3010 C CB  . VAL B 2 260 ? 214.563 266.544 362.327 1.00 7.21  ? 260 VAL B CB  1 
ATOM   3011 C CG1 . VAL B 2 260 ? 213.430 267.555 362.275 1.00 6.38  ? 260 VAL B CG1 1 
ATOM   3012 C CG2 . VAL B 2 260 ? 215.378 266.696 363.598 1.00 4.09  ? 260 VAL B CG2 1 
ATOM   3013 N N   . TYR B 2 261 ? 215.414 263.388 363.235 1.00 8.57  ? 261 TYR B N   1 
ATOM   3014 C CA  . TYR B 2 261 ? 216.414 262.334 363.262 1.00 5.61  ? 261 TYR B CA  1 
ATOM   3015 C C   . TYR B 2 261 ? 215.882 261.077 362.578 1.00 0.59  ? 261 TYR B C   1 
ATOM   3016 O O   . TYR B 2 261 ? 214.670 260.907 362.440 1.00 10.17 ? 261 TYR B O   1 
ATOM   3017 C CB  . TYR B 2 261 ? 216.793 261.995 364.698 1.00 5.50  ? 261 TYR B CB  1 
ATOM   3018 C CG  . TYR B 2 261 ? 217.506 263.096 365.443 1.00 4.24  ? 261 TYR B CG  1 
ATOM   3019 C CD1 . TYR B 2 261 ? 218.657 263.677 364.933 1.00 0.01  ? 261 TYR B CD1 1 
ATOM   3020 C CD2 . TYR B 2 261 ? 217.028 263.551 366.661 1.00 3.90  ? 261 TYR B CD2 1 
ATOM   3021 C CE1 . TYR B 2 261 ? 219.310 264.678 365.617 1.00 0.01  ? 261 TYR B CE1 1 
ATOM   3022 C CE2 . TYR B 2 261 ? 217.670 264.546 367.348 1.00 0.01  ? 261 TYR B CE2 1 
ATOM   3023 C CZ  . TYR B 2 261 ? 218.813 265.107 366.824 1.00 1.80  ? 261 TYR B CZ  1 
ATOM   3024 O OH  . TYR B 2 261 ? 219.452 266.101 367.516 1.00 0.01  ? 261 TYR B OH  1 
ATOM   3025 N N   . PRO B 2 262 ? 216.767 260.185 362.134 1.00 7.06  ? 262 PRO B N   1 
ATOM   3026 C CA  . PRO B 2 262 ? 216.311 258.856 361.716 1.00 12.82 ? 262 PRO B CA  1 
ATOM   3027 C C   . PRO B 2 262 ? 215.535 258.192 362.842 1.00 4.85  ? 262 PRO B C   1 
ATOM   3028 O O   . PRO B 2 262 ? 215.954 258.209 364.001 1.00 7.80  ? 262 PRO B O   1 
ATOM   3029 C CB  . PRO B 2 262 ? 217.615 258.114 361.404 1.00 10.45 ? 262 PRO B CB  1 
ATOM   3030 C CG  . PRO B 2 262 ? 218.589 259.189 361.081 1.00 4.94  ? 262 PRO B CG  1 
ATOM   3031 C CD  . PRO B 2 262 ? 218.216 260.359 361.931 1.00 1.93  ? 262 PRO B CD  1 
ATOM   3032 N N   . HIS B 2 263 ? 214.390 257.610 362.502 1.00 5.47  ? 263 HIS B N   1 
ATOM   3033 C CA  . HIS B 2 263 ? 213.477 257.162 363.540 1.00 6.36  ? 263 HIS B CA  1 
ATOM   3034 C C   . HIS B 2 263 ? 212.532 256.107 362.993 1.00 5.16  ? 263 HIS B C   1 
ATOM   3035 O O   . HIS B 2 263 ? 212.369 255.947 361.782 1.00 13.83 ? 263 HIS B O   1 
ATOM   3036 C CB  . HIS B 2 263 ? 212.670 258.331 364.110 1.00 4.01  ? 263 HIS B CB  1 
ATOM   3037 C CG  . HIS B 2 263 ? 211.663 258.881 363.151 1.00 8.74  ? 263 HIS B CG  1 
ATOM   3038 N ND1 . HIS B 2 263 ? 211.982 259.818 362.194 1.00 8.64  ? 263 HIS B ND1 1 
ATOM   3039 C CD2 . HIS B 2 263 ? 210.349 258.604 362.983 1.00 9.74  ? 263 HIS B CD2 1 
ATOM   3040 C CE1 . HIS B 2 263 ? 210.906 260.103 361.485 1.00 8.16  ? 263 HIS B CE1 1 
ATOM   3041 N NE2 . HIS B 2 263 ? 209.902 259.379 361.943 1.00 8.51  ? 263 HIS B NE2 1 
ATOM   3042 N N   . GLN B 2 264 ? 211.907 255.395 363.923 1.00 11.74 ? 264 GLN B N   1 
ATOM   3043 C CA  . GLN B 2 264 ? 210.814 254.481 363.644 1.00 9.63  ? 264 GLN B CA  1 
ATOM   3044 C C   . GLN B 2 264 ? 209.771 254.647 364.739 1.00 3.37  ? 264 GLN B C   1 
ATOM   3045 O O   . GLN B 2 264 ? 210.076 255.116 365.837 1.00 13.11 ? 264 GLN B O   1 
ATOM   3046 C CB  . GLN B 2 264 ? 211.299 253.028 363.577 1.00 9.76  ? 264 GLN B CB  1 
ATOM   3047 C CG  . GLN B 2 264 ? 210.300 252.067 362.982 1.00 16.86 ? 264 GLN B CG  1 
ATOM   3048 C CD  . GLN B 2 264 ? 210.064 252.325 361.516 1.00 22.71 ? 264 GLN B CD  1 
ATOM   3049 O OE1 . GLN B 2 264 ? 210.996 252.623 360.775 1.00 16.94 ? 264 GLN B OE1 1 
ATOM   3050 N NE2 . GLN B 2 264 ? 208.812 252.221 361.086 1.00 21.05 ? 264 GLN B NE2 1 
ATOM   3051 N N   . ILE B 2 265 ? 208.532 254.286 364.428 1.00 8.47  ? 265 ILE B N   1 
ATOM   3052 C CA  . ILE B 2 265 ? 207.443 254.293 365.398 1.00 8.48  ? 265 ILE B CA  1 
ATOM   3053 C C   . ILE B 2 265 ? 206.922 252.873 365.543 1.00 6.22  ? 265 ILE B C   1 
ATOM   3054 O O   . ILE B 2 265 ? 206.621 252.209 364.545 1.00 11.48 ? 265 ILE B O   1 
ATOM   3055 C CB  . ILE B 2 265 ? 206.314 255.256 364.989 1.00 6.94  ? 265 ILE B CB  1 
ATOM   3056 C CG1 . ILE B 2 265 ? 206.833 256.695 364.980 1.00 12.12 ? 265 ILE B CG1 1 
ATOM   3057 C CG2 . ILE B 2 265 ? 205.124 255.117 365.942 1.00 7.00  ? 265 ILE B CG2 1 
ATOM   3058 C CD1 . ILE B 2 265 ? 205.792 257.734 364.640 1.00 9.37  ? 265 ILE B CD1 1 
ATOM   3059 N N   . ILE B 2 266 ? 206.833 252.408 366.781 1.00 5.34  ? 266 ILE B N   1 
ATOM   3060 C CA  . ILE B 2 266 ? 206.213 251.131 367.105 1.00 9.88  ? 266 ILE B CA  1 
ATOM   3061 C C   . ILE B 2 266 ? 204.838 251.451 367.678 1.00 3.90  ? 266 ILE B C   1 
ATOM   3062 O O   . ILE B 2 266 ? 204.714 251.832 368.840 1.00 9.71  ? 266 ILE B O   1 
ATOM   3063 C CB  . ILE B 2 266 ? 207.062 250.316 368.084 1.00 12.64 ? 266 ILE B CB  1 
ATOM   3064 C CG1 . ILE B 2 266 ? 208.372 249.894 367.419 1.00 5.40  ? 266 ILE B CG1 1 
ATOM   3065 C CG2 . ILE B 2 266 ? 206.283 249.100 368.574 1.00 10.85 ? 266 ILE B CG2 1 
ATOM   3066 C CD1 . ILE B 2 266 ? 209.364 249.252 368.359 1.00 12.53 ? 266 ILE B CD1 1 
ATOM   3067 N N   . ASN B 2 267 ? 203.805 251.310 366.857 1.00 6.15  ? 267 ASN B N   1 
ATOM   3068 C CA  . ASN B 2 267 ? 202.424 251.458 367.293 1.00 10.14 ? 267 ASN B CA  1 
ATOM   3069 C C   . ASN B 2 267 ? 201.884 250.064 367.582 1.00 9.36  ? 267 ASN B C   1 
ATOM   3070 O O   . ASN B 2 267 ? 201.888 249.202 366.700 1.00 13.20 ? 267 ASN B O   1 
ATOM   3071 C CB  . ASN B 2 267 ? 201.591 252.170 366.226 1.00 14.36 ? 267 ASN B CB  1 
ATOM   3072 C CG  . ASN B 2 267 ? 200.272 252.693 366.759 1.00 10.83 ? 267 ASN B CG  1 
ATOM   3073 O OD1 . ASN B 2 267 ? 199.996 252.624 367.952 1.00 13.09 ? 267 ASN B OD1 1 
ATOM   3074 N ND2 . ASN B 2 267 ? 199.453 253.232 365.869 1.00 9.60  ? 267 ASN B ND2 1 
ATOM   3075 N N   . LEU B 2 268 ? 201.437 249.840 368.819 1.00 5.93  ? 268 LEU B N   1 
ATOM   3076 C CA  . LEU B 2 268 ? 201.119 248.482 369.248 1.00 12.30 ? 268 LEU B CA  1 
ATOM   3077 C C   . LEU B 2 268 ? 200.006 247.860 368.416 1.00 11.48 ? 268 LEU B C   1 
ATOM   3078 O O   . LEU B 2 268 ? 199.974 246.638 368.243 1.00 12.64 ? 268 LEU B O   1 
ATOM   3079 C CB  . LEU B 2 268 ? 200.741 248.468 370.729 1.00 8.11  ? 268 LEU B CB  1 
ATOM   3080 C CG  . LEU B 2 268 ? 201.891 248.645 371.728 1.00 8.49  ? 268 LEU B CG  1 
ATOM   3081 C CD1 . LEU B 2 268 ? 201.395 248.469 373.144 1.00 6.57  ? 268 LEU B CD1 1 
ATOM   3082 C CD2 . LEU B 2 268 ? 203.036 247.686 371.445 1.00 11.89 ? 268 LEU B CD2 1 
ATOM   3083 N N   . ARG B 2 269 ? 199.095 248.672 367.886 1.00 5.89  ? 269 ARG B N   1 
ATOM   3084 C CA  . ARG B 2 269 ? 198.012 248.137 367.074 1.00 8.38  ? 269 ARG B CA  1 
ATOM   3085 C C   . ARG B 2 269 ? 198.457 247.760 365.667 1.00 10.65 ? 269 ARG B C   1 
ATOM   3086 O O   . ARG B 2 269 ? 197.708 247.076 364.964 1.00 12.52 ? 269 ARG B O   1 
ATOM   3087 C CB  . ARG B 2 269 ? 196.868 249.150 366.997 1.00 7.78  ? 269 ARG B CB  1 
ATOM   3088 C CG  . ARG B 2 269 ? 197.102 250.297 366.033 1.00 6.57  ? 269 ARG B CG  1 
ATOM   3089 C CD  . ARG B 2 269 ? 196.137 251.439 366.290 1.00 9.30  ? 269 ARG B CD  1 
ATOM   3090 N NE  . ARG B 2 269 ? 194.747 251.001 366.333 1.00 14.29 ? 269 ARG B NE  1 
ATOM   3091 C CZ  . ARG B 2 269 ? 193.956 250.885 365.274 1.00 11.93 ? 269 ARG B CZ  1 
ATOM   3092 N NH1 . ARG B 2 269 ? 194.391 251.144 364.053 1.00 12.50 ? 269 ARG B NH1 1 
ATOM   3093 N NH2 . ARG B 2 269 ? 192.698 250.494 365.446 1.00 9.73  ? 269 ARG B NH2 1 
ATOM   3094 N N   . THR B 2 270 ? 199.648 248.171 365.248 1.00 11.21 ? 270 THR B N   1 
ATOM   3095 C CA  . THR B 2 270 ? 200.125 247.959 363.887 1.00 12.06 ? 270 THR B CA  1 
ATOM   3096 C C   . THR B 2 270 ? 201.331 247.040 363.802 1.00 10.92 ? 270 THR B C   1 
ATOM   3097 O O   . THR B 2 270 ? 201.293 246.052 363.069 1.00 20.02 ? 270 THR B O   1 
ATOM   3098 C CB  . THR B 2 270 ? 200.482 249.310 363.243 1.00 16.62 ? 270 THR B CB  1 
ATOM   3099 O OG1 . THR B 2 270 ? 199.311 250.129 363.150 1.00 22.43 ? 270 THR B OG1 1 
ATOM   3100 C CG2 . THR B 2 270 ? 201.068 249.107 361.858 1.00 17.42 ? 270 THR B CG2 1 
ATOM   3101 N N   . ASN B 2 271 ? 202.403 247.336 364.534 1.00 14.21 ? 271 ASN B N   1 
ATOM   3102 C CA  . ASN B 2 271 ? 203.643 246.586 364.413 1.00 12.31 ? 271 ASN B CA  1 
ATOM   3103 C C   . ASN B 2 271 ? 204.239 246.388 365.797 1.00 14.60 ? 271 ASN B C   1 
ATOM   3104 O O   . ASN B 2 271 ? 203.895 247.091 366.750 1.00 23.00 ? 271 ASN B O   1 
ATOM   3105 C CB  . ASN B 2 271 ? 204.643 247.294 363.489 1.00 14.58 ? 271 ASN B CB  1 
ATOM   3106 C CG  . ASN B 2 271 ? 205.092 248.644 364.026 1.00 13.86 ? 271 ASN B CG  1 
ATOM   3107 O OD1 . ASN B 2 271 ? 204.372 249.300 364.773 1.00 14.26 ? 271 ASN B OD1 1 
ATOM   3108 N ND2 . ASN B 2 271 ? 206.290 249.062 363.640 1.00 18.26 ? 271 ASN B ND2 1 
ATOM   3109 N N   . ASN B 2 272 ? 205.136 245.407 365.898 1.00 16.99 ? 272 ASN B N   1 
ATOM   3110 C CA  . ASN B 2 272 ? 205.783 245.078 367.161 1.00 16.94 ? 272 ASN B CA  1 
ATOM   3111 C C   . ASN B 2 272 ? 207.304 245.165 367.087 1.00 17.85 ? 272 ASN B C   1 
ATOM   3112 O O   . ASN B 2 272 ? 207.977 244.794 368.053 1.00 22.24 ? 272 ASN B O   1 
ATOM   3113 C CB  . ASN B 2 272 ? 205.368 243.675 367.625 1.00 16.67 ? 272 ASN B CB  1 
ATOM   3114 C CG  . ASN B 2 272 ? 205.686 242.603 366.604 1.00 15.84 ? 272 ASN B CG  1 
ATOM   3115 O OD1 . ASN B 2 272 ? 206.567 242.766 365.763 1.00 20.25 ? 272 ASN B OD1 1 
ATOM   3116 N ND2 . ASN B 2 272 ? 204.967 241.494 366.674 1.00 18.64 ? 272 ASN B ND2 1 
ATOM   3117 N N   . CYS B 2 273 ? 207.865 245.643 365.979 1.00 15.17 ? 273 CYS B N   1 
ATOM   3118 C CA  . CYS B 2 273 ? 209.311 245.714 365.850 1.00 13.84 ? 273 CYS B CA  1 
ATOM   3119 C C   . CYS B 2 273 ? 209.700 246.920 365.009 1.00 16.97 ? 273 CYS B C   1 
ATOM   3120 O O   . CYS B 2 273 ? 208.924 247.387 364.174 1.00 19.49 ? 273 CYS B O   1 
ATOM   3121 C CB  . CYS B 2 273 ? 209.880 244.434 365.224 1.00 17.52 ? 273 CYS B CB  1 
ATOM   3122 S SG  . CYS B 2 273 ? 209.555 244.251 363.460 1.00 44.48 ? 273 CYS B SG  1 
ATOM   3123 N N   . ALA B 2 274 ? 210.909 247.416 365.248 1.00 13.56 ? 274 ALA B N   1 
ATOM   3124 C CA  . ALA B 2 274 ? 211.488 248.521 364.496 1.00 9.74  ? 274 ALA B CA  1 
ATOM   3125 C C   . ALA B 2 274 ? 212.913 248.167 364.098 1.00 10.83 ? 274 ALA B C   1 
ATOM   3126 O O   . ALA B 2 274 ? 213.629 247.518 364.861 1.00 11.93 ? 274 ALA B O   1 
ATOM   3127 C CB  . ALA B 2 274 ? 211.480 249.809 365.317 1.00 13.17 ? 274 ALA B CB  1 
ATOM   3128 N N   . THR B 2 275 ? 213.325 248.590 362.905 1.00 10.99 ? 275 THR B N   1 
ATOM   3129 C CA  . THR B 2 275 ? 214.663 248.304 362.396 1.00 12.62 ? 275 THR B CA  1 
ATOM   3130 C C   . THR B 2 275 ? 215.267 249.576 361.820 1.00 12.15 ? 275 THR B C   1 
ATOM   3131 O O   . THR B 2 275 ? 214.721 250.152 360.875 1.00 18.44 ? 275 THR B O   1 
ATOM   3132 C CB  . THR B 2 275 ? 214.627 247.198 361.336 1.00 19.21 ? 275 THR B CB  1 
ATOM   3133 O OG1 . THR B 2 275 ? 214.181 245.976 361.933 1.00 20.72 ? 275 THR B OG1 1 
ATOM   3134 C CG2 . THR B 2 275 ? 216.008 246.981 360.730 1.00 18.32 ? 275 THR B CG2 1 
ATOM   3135 N N   . LEU B 2 276 ? 216.395 250.001 362.385 1.00 14.84 ? 276 LEU B N   1 
ATOM   3136 C CA  . LEU B 2 276 ? 217.130 251.177 361.928 1.00 9.63  ? 276 LEU B CA  1 
ATOM   3137 C C   . LEU B 2 276 ? 218.526 250.757 361.483 1.00 12.32 ? 276 LEU B C   1 
ATOM   3138 O O   . LEU B 2 276 ? 219.263 250.134 362.250 1.00 13.69 ? 276 LEU B O   1 
ATOM   3139 C CB  . LEU B 2 276 ? 217.223 252.230 363.034 1.00 10.94 ? 276 LEU B CB  1 
ATOM   3140 C CG  . LEU B 2 276 ? 215.923 252.895 363.500 1.00 18.75 ? 276 LEU B CG  1 
ATOM   3141 C CD1 . LEU B 2 276 ? 216.196 253.931 364.581 1.00 11.87 ? 276 LEU B CD1 1 
ATOM   3142 C CD2 . LEU B 2 276 ? 215.193 253.532 362.335 1.00 14.19 ? 276 LEU B CD2 1 
ATOM   3143 N N   . VAL B 2 277 ? 218.890 251.103 360.254 1.00 10.68 ? 277 VAL B N   1 
ATOM   3144 C CA  . VAL B 2 277 ? 220.228 250.855 359.730 1.00 9.73  ? 277 VAL B CA  1 
ATOM   3145 C C   . VAL B 2 277 ? 220.982 252.179 359.753 1.00 10.45 ? 277 VAL B C   1 
ATOM   3146 O O   . VAL B 2 277 ? 220.711 253.076 358.950 1.00 9.25  ? 277 VAL B O   1 
ATOM   3147 C CB  . VAL B 2 277 ? 220.184 250.256 358.317 1.00 13.66 ? 277 VAL B CB  1 
ATOM   3148 C CG1 . VAL B 2 277 ? 221.588 249.987 357.808 1.00 17.53 ? 277 VAL B CG1 1 
ATOM   3149 C CG2 . VAL B 2 277 ? 219.366 248.976 358.304 1.00 11.82 ? 277 VAL B CG2 1 
ATOM   3150 N N   . LEU B 2 278 ? 221.936 252.302 360.675 1.00 14.14 ? 278 LEU B N   1 
ATOM   3151 C CA  . LEU B 2 278 ? 222.682 253.532 360.875 1.00 10.74 ? 278 LEU B CA  1 
ATOM   3152 C C   . LEU B 2 278 ? 224.048 253.415 360.225 1.00 5.51  ? 278 LEU B C   1 
ATOM   3153 O O   . LEU B 2 278 ? 224.845 252.572 360.658 1.00 17.15 ? 278 LEU B O   1 
ATOM   3154 C CB  . LEU B 2 278 ? 222.840 253.816 362.362 1.00 5.88  ? 278 LEU B CB  1 
ATOM   3155 C CG  . LEU B 2 278 ? 221.590 253.647 363.219 1.00 8.48  ? 278 LEU B CG  1 
ATOM   3156 C CD1 . LEU B 2 278 ? 221.877 254.057 364.648 1.00 5.53  ? 278 LEU B CD1 1 
ATOM   3157 C CD2 . LEU B 2 278 ? 220.434 254.446 362.646 1.00 9.94  ? 278 LEU B CD2 1 
ATOM   3158 N N   . PRO B 2 279 ? 224.380 254.209 359.212 1.00 15.98 ? 279 PRO B N   1 
ATOM   3159 C CA  . PRO B 2 279 ? 225.763 254.230 358.732 1.00 11.50 ? 279 PRO B CA  1 
ATOM   3160 C C   . PRO B 2 279 ? 226.665 254.942 359.725 1.00 4.04  ? 279 PRO B C   1 
ATOM   3161 O O   . PRO B 2 279 ? 226.213 255.658 360.620 1.00 14.29 ? 279 PRO B O   1 
ATOM   3162 C CB  . PRO B 2 279 ? 225.670 254.992 357.409 1.00 10.45 ? 279 PRO B CB  1 
ATOM   3163 C CG  . PRO B 2 279 ? 224.512 255.892 357.588 1.00 11.08 ? 279 PRO B CG  1 
ATOM   3164 C CD  . PRO B 2 279 ? 223.538 255.172 358.482 1.00 10.24 ? 279 PRO B CD  1 
ATOM   3165 N N   . TYR B 2 280 ? 227.964 254.718 359.570 1.00 12.29 ? 280 TYR B N   1 
ATOM   3166 C CA  . TYR B 2 280 ? 228.933 255.436 360.381 1.00 7.43  ? 280 TYR B CA  1 
ATOM   3167 C C   . TYR B 2 280 ? 228.870 256.921 360.051 1.00 9.18  ? 280 TYR B C   1 
ATOM   3168 O O   . TYR B 2 280 ? 229.070 257.319 358.901 1.00 11.65 ? 280 TYR B O   1 
ATOM   3169 C CB  . TYR B 2 280 ? 230.337 254.886 360.140 1.00 10.15 ? 280 TYR B CB  1 
ATOM   3170 C CG  . TYR B 2 280 ? 231.408 255.581 360.947 1.00 6.95  ? 280 TYR B CG  1 
ATOM   3171 C CD1 . TYR B 2 280 ? 231.614 255.264 362.281 1.00 7.85  ? 280 TYR B CD1 1 
ATOM   3172 C CD2 . TYR B 2 280 ? 232.210 256.557 360.375 1.00 2.66  ? 280 TYR B CD2 1 
ATOM   3173 C CE1 . TYR B 2 280 ? 232.584 255.896 363.020 1.00 9.38  ? 280 TYR B CE1 1 
ATOM   3174 C CE2 . TYR B 2 280 ? 233.186 257.193 361.106 1.00 5.53  ? 280 TYR B CE2 1 
ATOM   3175 C CZ  . TYR B 2 280 ? 233.370 256.858 362.428 1.00 12.72 ? 280 TYR B CZ  1 
ATOM   3176 O OH  . TYR B 2 280 ? 234.342 257.491 363.160 1.00 14.30 ? 280 TYR B OH  1 
ATOM   3177 N N   . VAL B 2 281 ? 228.576 257.736 361.059 1.00 4.66  ? 281 VAL B N   1 
ATOM   3178 C CA  . VAL B 2 281 ? 228.440 259.179 360.906 1.00 8.98  ? 281 VAL B CA  1 
ATOM   3179 C C   . VAL B 2 281 ? 229.447 259.847 361.828 1.00 7.98  ? 281 VAL B C   1 
ATOM   3180 O O   . VAL B 2 281 ? 229.481 259.562 363.029 1.00 13.60 ? 281 VAL B O   1 
ATOM   3181 C CB  . VAL B 2 281 ? 227.007 259.652 361.221 1.00 13.30 ? 281 VAL B CB  1 
ATOM   3182 C CG1 . VAL B 2 281 ? 226.935 261.168 361.245 1.00 7.46  ? 281 VAL B CG1 1 
ATOM   3183 C CG2 . VAL B 2 281 ? 226.032 259.096 360.201 1.00 11.22 ? 281 VAL B CG2 1 
ATOM   3184 N N   . ASN B 2 282 ? 230.264 260.732 361.267 1.00 9.36  ? 282 ASN B N   1 
ATOM   3185 C CA  . ASN B 2 282 ? 231.299 261.408 362.036 1.00 9.76  ? 282 ASN B CA  1 
ATOM   3186 C C   . ASN B 2 282 ? 231.933 262.469 361.153 1.00 3.80  ? 282 ASN B C   1 
ATOM   3187 O O   . ASN B 2 282 ? 231.831 262.418 359.926 1.00 10.79 ? 282 ASN B O   1 
ATOM   3188 C CB  . ASN B 2 282 ? 232.358 260.418 362.538 1.00 11.01 ? 282 ASN B CB  1 
ATOM   3189 C CG  . ASN B 2 282 ? 233.184 260.973 363.671 1.00 8.41  ? 282 ASN B CG  1 
ATOM   3190 O OD1 . ASN B 2 282 ? 232.914 262.057 364.179 1.00 22.55 ? 282 ASN B OD1 1 
ATOM   3191 N ND2 . ASN B 2 282 ? 234.192 260.225 364.084 1.00 9.19  ? 282 ASN B ND2 1 
ATOM   3192 N N   . SER B 2 283 ? 232.595 263.430 361.794 1.00 6.90  ? 283 SER B N   1 
ATOM   3193 C CA  . SER B 2 283 ? 233.393 264.407 361.067 1.00 6.54  ? 283 SER B CA  1 
ATOM   3194 C C   . SER B 2 283 ? 234.733 263.839 360.617 1.00 12.06 ? 283 SER B C   1 
ATOM   3195 O O   . SER B 2 283 ? 235.457 264.514 359.880 1.00 12.54 ? 283 SER B O   1 
ATOM   3196 C CB  . SER B 2 283 ? 233.618 265.648 361.930 1.00 7.63  ? 283 SER B CB  1 
ATOM   3197 O OG  . SER B 2 283 ? 234.212 265.310 363.169 1.00 19.07 ? 283 SER B OG  1 
ATOM   3198 N N   . LEU B 2 284 ? 235.067 262.622 361.036 1.00 17.76 ? 284 LEU B N   1 
ATOM   3199 C CA  . LEU B 2 284 ? 236.296 261.942 360.669 1.00 6.08  ? 284 LEU B CA  1 
ATOM   3200 C C   . LEU B 2 284 ? 235.966 260.634 359.966 1.00 9.03  ? 284 LEU B C   1 
ATOM   3201 O O   . LEU B 2 284 ? 234.861 260.102 360.088 1.00 14.13 ? 284 LEU B O   1 
ATOM   3202 C CB  . LEU B 2 284 ? 237.158 261.666 361.905 1.00 12.82 ? 284 LEU B CB  1 
ATOM   3203 C CG  . LEU B 2 284 ? 237.665 262.907 362.634 1.00 13.49 ? 284 LEU B CG  1 
ATOM   3204 C CD1 . LEU B 2 284 ? 238.201 262.546 364.004 1.00 7.51  ? 284 LEU B CD1 1 
ATOM   3205 C CD2 . LEU B 2 284 ? 238.727 263.596 361.797 1.00 9.81  ? 284 LEU B CD2 1 
ATOM   3206 N N   . SER B 2 285 ? 236.941 260.121 359.214 1.00 5.21  ? 285 SER B N   1 
ATOM   3207 C CA  . SER B 2 285 ? 236.771 258.817 358.582 1.00 12.67 ? 285 SER B CA  1 
ATOM   3208 C C   . SER B 2 285 ? 236.797 257.693 359.608 1.00 13.00 ? 285 SER B C   1 
ATOM   3209 O O   . SER B 2 285 ? 236.124 256.674 359.425 1.00 15.74 ? 285 SER B O   1 
ATOM   3210 C CB  . SER B 2 285 ? 237.857 258.592 357.533 1.00 11.97 ? 285 SER B CB  1 
ATOM   3211 O OG  . SER B 2 285 ? 237.797 259.575 356.520 1.00 24.93 ? 285 SER B OG  1 
ATOM   3212 N N   . ILE B 2 286 ? 237.566 257.857 360.681 1.00 10.95 ? 286 ILE B N   1 
ATOM   3213 C CA  . ILE B 2 286 ? 237.648 256.864 361.742 1.00 8.64  ? 286 ILE B CA  1 
ATOM   3214 C C   . ILE B 2 286 ? 238.106 257.589 362.995 1.00 9.26  ? 286 ILE B C   1 
ATOM   3215 O O   . ILE B 2 286 ? 238.837 258.578 362.922 1.00 18.57 ? 286 ILE B O   1 
ATOM   3216 C CB  . ILE B 2 286 ? 238.597 255.701 361.349 1.00 15.42 ? 286 ILE B CB  1 
ATOM   3217 C CG1 . ILE B 2 286 ? 238.475 254.550 362.348 1.00 8.04  ? 286 ILE B CG1 1 
ATOM   3218 C CG2 . ILE B 2 286 ? 240.036 256.185 361.257 1.00 10.39 ? 286 ILE B CG2 1 
ATOM   3219 C CD1 . ILE B 2 286 ? 239.103 253.266 361.872 1.00 10.53 ? 286 ILE B CD1 1 
ATOM   3220 N N   . ASP B 2 287 ? 237.667 257.101 364.151 1.00 11.20 ? 287 ASP B N   1 
ATOM   3221 C CA  . ASP B 2 287 ? 237.878 257.798 365.409 1.00 5.86  ? 287 ASP B CA  1 
ATOM   3222 C C   . ASP B 2 287 ? 238.215 256.779 366.488 1.00 7.29  ? 287 ASP B C   1 
ATOM   3223 O O   . ASP B 2 287 ? 238.341 255.582 366.226 1.00 3.66  ? 287 ASP B O   1 
ATOM   3224 C CB  . ASP B 2 287 ? 236.637 258.623 365.777 1.00 11.88 ? 287 ASP B CB  1 
ATOM   3225 C CG  . ASP B 2 287 ? 236.953 259.795 366.683 1.00 11.44 ? 287 ASP B CG  1 
ATOM   3226 O OD1 . ASP B 2 287 ? 237.918 259.711 367.466 1.00 14.54 ? 287 ASP B OD1 1 
ATOM   3227 O OD2 . ASP B 2 287 ? 236.228 260.804 366.615 1.00 23.51 ? 287 ASP B OD2 1 
ATOM   3228 N N   . SER B 2 288 ? 238.373 257.266 367.713 1.00 8.61  ? 288 SER B N   1 
ATOM   3229 C CA  . SER B 2 288 ? 238.563 256.412 368.877 1.00 7.74  ? 288 SER B CA  1 
ATOM   3230 C C   . SER B 2 288 ? 237.200 255.980 369.404 1.00 10.71 ? 288 SER B C   1 
ATOM   3231 O O   . SER B 2 288 ? 236.376 256.824 369.771 1.00 17.59 ? 288 SER B O   1 
ATOM   3232 C CB  . SER B 2 288 ? 239.351 257.150 369.956 1.00 9.83  ? 288 SER B CB  1 
ATOM   3233 O OG  . SER B 2 288 ? 239.328 256.446 371.182 1.00 17.42 ? 288 SER B OG  1 
ATOM   3234 N N   . MET B 2 289 ? 236.963 254.668 369.443 1.00 16.56 ? 289 MET B N   1 
ATOM   3235 C CA  . MET B 2 289 ? 235.671 254.161 369.890 1.00 8.45  ? 289 MET B CA  1 
ATOM   3236 C C   . MET B 2 289 ? 235.479 254.292 371.394 1.00 9.42  ? 289 MET B C   1 
ATOM   3237 O O   . MET B 2 289 ? 234.336 254.284 371.858 1.00 17.97 ? 289 MET B O   1 
ATOM   3238 C CB  . MET B 2 289 ? 235.508 252.701 369.475 1.00 8.11  ? 289 MET B CB  1 
ATOM   3239 C CG  . MET B 2 289 ? 235.116 252.516 368.025 1.00 12.31 ? 289 MET B CG  1 
ATOM   3240 S SD  . MET B 2 289 ? 234.683 250.810 367.648 1.00 29.32 ? 289 MET B SD  1 
ATOM   3241 C CE  . MET B 2 289 ? 233.616 251.026 366.234 1.00 16.01 ? 289 MET B CE  1 
ATOM   3242 N N   . THR B 2 290 ? 236.557 254.410 372.164 1.00 13.35 ? 290 THR B N   1 
ATOM   3243 C CA  . THR B 2 290 ? 236.441 254.577 373.606 1.00 11.63 ? 290 THR B CA  1 
ATOM   3244 C C   . THR B 2 290 ? 236.285 256.030 374.026 1.00 8.08  ? 290 THR B C   1 
ATOM   3245 O O   . THR B 2 290 ? 235.767 256.291 375.116 1.00 11.52 ? 290 THR B O   1 
ATOM   3246 C CB  . THR B 2 290 ? 237.664 253.981 374.312 1.00 12.90 ? 290 THR B CB  1 
ATOM   3247 O OG1 . THR B 2 290 ? 238.861 254.502 373.725 1.00 15.03 ? 290 THR B OG1 1 
ATOM   3248 C CG2 . THR B 2 290 ? 237.666 252.470 374.199 1.00 9.97  ? 290 THR B CG2 1 
ATOM   3249 N N   . LYS B 2 291 ? 236.726 256.978 373.200 1.00 14.47 ? 291 LYS B N   1 
ATOM   3250 C CA  . LYS B 2 291 ? 236.569 258.388 373.533 1.00 9.24  ? 291 LYS B CA  1 
ATOM   3251 C C   . LYS B 2 291 ? 235.212 258.928 373.109 1.00 12.13 ? 291 LYS B C   1 
ATOM   3252 O O   . LYS B 2 291 ? 234.660 259.805 373.780 1.00 10.50 ? 291 LYS B O   1 
ATOM   3253 C CB  . LYS B 2 291 ? 237.666 259.216 372.864 1.00 9.65  ? 291 LYS B CB  1 
ATOM   3254 C CG  . LYS B 2 291 ? 239.010 259.162 373.549 1.00 9.47  ? 291 LYS B CG  1 
ATOM   3255 C CD  . LYS B 2 291 ? 240.030 260.054 372.856 1.00 9.32  ? 291 LYS B CD  1 
ATOM   3256 C CE  . LYS B 2 291 ? 241.378 259.990 373.555 1.00 12.59 ? 291 LYS B CE  1 
ATOM   3257 N NZ  . LYS B 2 291 ? 242.364 260.933 372.973 1.00 15.74 ? 291 LYS B NZ  1 
ATOM   3258 N N   . HIS B 2 292 ? 234.662 258.414 372.015 1.00 13.28 ? 292 HIS B N   1 
ATOM   3259 C CA  . HIS B 2 292 ? 233.575 259.064 371.304 1.00 8.60  ? 292 HIS B CA  1 
ATOM   3260 C C   . HIS B 2 292 ? 232.475 258.059 371.002 1.00 9.03  ? 292 HIS B C   1 
ATOM   3261 O O   . HIS B 2 292 ? 232.749 256.958 370.516 1.00 9.96  ? 292 HIS B O   1 
ATOM   3262 C CB  . HIS B 2 292 ? 234.100 259.683 370.007 1.00 7.77  ? 292 HIS B CB  1 
ATOM   3263 C CG  . HIS B 2 292 ? 233.102 260.535 369.295 1.00 8.91  ? 292 HIS B CG  1 
ATOM   3264 N ND1 . HIS B 2 292 ? 233.014 260.584 367.922 1.00 10.47 ? 292 HIS B ND1 1 
ATOM   3265 C CD2 . HIS B 2 292 ? 232.159 261.383 369.763 1.00 6.81  ? 292 HIS B CD2 1 
ATOM   3266 C CE1 . HIS B 2 292 ? 232.052 261.417 367.576 1.00 11.49 ? 292 HIS B CE1 1 
ATOM   3267 N NE2 . HIS B 2 292 ? 231.519 261.917 368.674 1.00 11.26 ? 292 HIS B NE2 1 
ATOM   3268 N N   . ASN B 2 293 ? 231.236 258.441 371.287 1.00 7.70  ? 293 ASN B N   1 
ATOM   3269 C CA  . ASN B 2 293 ? 230.063 257.682 370.873 1.00 4.08  ? 293 ASN B CA  1 
ATOM   3270 C C   . ASN B 2 293 ? 229.502 258.322 369.612 1.00 1.37  ? 293 ASN B C   1 
ATOM   3271 O O   . ASN B 2 293 ? 229.148 259.504 369.617 1.00 7.46  ? 293 ASN B O   1 
ATOM   3272 C CB  . ASN B 2 293 ? 229.012 257.649 371.980 1.00 4.90  ? 293 ASN B CB  1 
ATOM   3273 C CG  . ASN B 2 293 ? 229.385 256.716 373.106 1.00 4.43  ? 293 ASN B CG  1 
ATOM   3274 O OD1 . ASN B 2 293 ? 229.707 255.556 372.877 1.00 5.53  ? 293 ASN B OD1 1 
ATOM   3275 N ND2 . ASN B 2 293 ? 229.355 257.220 374.328 1.00 7.81  ? 293 ASN B ND2 1 
ATOM   3276 N N   . ASN B 2 294 ? 229.447 257.549 368.530 1.00 7.50  ? 294 ASN B N   1 
ATOM   3277 C CA  . ASN B 2 294 ? 228.964 258.083 367.265 1.00 7.91  ? 294 ASN B CA  1 
ATOM   3278 C C   . ASN B 2 294 ? 227.448 258.199 367.231 1.00 5.12  ? 294 ASN B C   1 
ATOM   3279 O O   . ASN B 2 294 ? 226.923 259.144 366.635 1.00 11.90 ? 294 ASN B O   1 
ATOM   3280 C CB  . ASN B 2 294 ? 229.442 257.210 366.105 1.00 8.59  ? 294 ASN B CB  1 
ATOM   3281 C CG  . ASN B 2 294 ? 230.946 257.067 366.070 1.00 13.31 ? 294 ASN B CG  1 
ATOM   3282 O OD1 . ASN B 2 294 ? 231.662 257.991 365.686 1.00 18.44 ? 294 ASN B OD1 1 
ATOM   3283 N ND2 . ASN B 2 294 ? 231.437 255.902 366.471 1.00 19.36 ? 294 ASN B ND2 1 
ATOM   3284 N N   . TRP B 2 295 ? 226.729 257.266 367.851 1.00 10.28 ? 295 TRP B N   1 
ATOM   3285 C CA  . TRP B 2 295 ? 225.277 257.256 367.766 1.00 2.12  ? 295 TRP B CA  1 
ATOM   3286 C C   . TRP B 2 295 ? 224.662 257.190 369.154 1.00 8.47  ? 295 TRP B C   1 
ATOM   3287 O O   . TRP B 2 295 ? 225.274 256.704 370.102 1.00 12.03 ? 295 TRP B O   1 
ATOM   3288 C CB  . TRP B 2 295 ? 224.769 256.079 366.929 1.00 7.53  ? 295 TRP B CB  1 
ATOM   3289 C CG  . TRP B 2 295 ? 224.877 256.273 365.448 1.00 0.28  ? 295 TRP B CG  1 
ATOM   3290 C CD1 . TRP B 2 295 ? 225.839 255.776 364.627 1.00 0.01  ? 295 TRP B CD1 1 
ATOM   3291 C CD2 . TRP B 2 295 ? 223.977 257.008 364.611 1.00 5.99  ? 295 TRP B CD2 1 
ATOM   3292 N NE1 . TRP B 2 295 ? 225.598 256.152 363.332 1.00 0.57  ? 295 TRP B NE1 1 
ATOM   3293 C CE2 . TRP B 2 295 ? 224.461 256.912 363.295 1.00 3.24  ? 295 TRP B CE2 1 
ATOM   3294 C CE3 . TRP B 2 295 ? 222.809 257.737 364.847 1.00 0.01  ? 295 TRP B CE3 1 
ATOM   3295 C CZ2 . TRP B 2 295 ? 223.819 257.519 362.220 1.00 4.04  ? 295 TRP B CZ2 1 
ATOM   3296 C CZ3 . TRP B 2 295 ? 222.178 258.337 363.781 1.00 3.24  ? 295 TRP B CZ3 1 
ATOM   3297 C CH2 . TRP B 2 295 ? 222.681 258.225 362.485 1.00 8.36  ? 295 TRP B CH2 1 
ATOM   3298 N N   . GLY B 2 296 ? 223.447 257.698 369.262 1.00 5.26  ? 296 GLY B N   1 
ATOM   3299 C CA  . GLY B 2 296 ? 222.627 257.514 370.447 1.00 3.41  ? 296 GLY B CA  1 
ATOM   3300 C C   . GLY B 2 296 ? 221.277 256.963 370.038 1.00 5.73  ? 296 GLY B C   1 
ATOM   3301 O O   . GLY B 2 296 ? 220.763 257.301 368.975 1.00 9.00  ? 296 GLY B O   1 
ATOM   3302 N N   . ILE B 2 297 ? 220.721 256.099 370.875 1.00 5.62  ? 297 ILE B N   1 
ATOM   3303 C CA  . ILE B 2 297 ? 219.395 255.531 370.668 1.00 4.49  ? 297 ILE B CA  1 
ATOM   3304 C C   . ILE B 2 297 ? 218.517 256.026 371.802 1.00 5.67  ? 297 ILE B C   1 
ATOM   3305 O O   . ILE B 2 297 ? 218.853 255.844 372.975 1.00 6.94  ? 297 ILE B O   1 
ATOM   3306 C CB  . ILE B 2 297 ? 219.427 253.996 370.627 1.00 8.72  ? 297 ILE B CB  1 
ATOM   3307 C CG1 . ILE B 2 297 ? 220.383 253.494 369.537 1.00 13.82 ? 297 ILE B CG1 1 
ATOM   3308 C CG2 . ILE B 2 297 ? 218.025 253.444 370.416 1.00 8.21  ? 297 ILE B CG2 1 
ATOM   3309 C CD1 . ILE B 2 297 ? 220.014 253.906 368.134 1.00 8.80  ? 297 ILE B CD1 1 
ATOM   3310 N N   . ALA B 2 298 ? 217.405 256.668 371.456 1.00 7.98  ? 298 ALA B N   1 
ATOM   3311 C CA  . ALA B 2 298 ? 216.438 257.150 372.432 1.00 8.29  ? 298 ALA B CA  1 
ATOM   3312 C C   . ALA B 2 298 ? 215.077 256.545 372.128 1.00 6.55  ? 298 ALA B C   1 
ATOM   3313 O O   . ALA B 2 298 ? 214.600 256.623 370.995 1.00 9.69  ? 298 ALA B O   1 
ATOM   3314 C CB  . ALA B 2 298 ? 216.355 258.677 372.418 1.00 6.03  ? 298 ALA B CB  1 
ATOM   3315 N N   . ILE B 2 299 ? 214.450 255.948 373.134 1.00 9.11  ? 299 ILE B N   1 
ATOM   3316 C CA  . ILE B 2 299 ? 213.124 255.362 372.993 1.00 9.97  ? 299 ILE B CA  1 
ATOM   3317 C C   . ILE B 2 299 ? 212.192 256.083 373.954 1.00 5.74  ? 299 ILE B C   1 
ATOM   3318 O O   . ILE B 2 299 ? 212.370 256.007 375.174 1.00 4.65  ? 299 ILE B O   1 
ATOM   3319 C CB  . ILE B 2 299 ? 213.134 253.847 373.250 1.00 6.99  ? 299 ILE B CB  1 
ATOM   3320 C CG1 . ILE B 2 299 ? 214.090 253.164 372.267 1.00 4.46  ? 299 ILE B CG1 1 
ATOM   3321 C CG2 . ILE B 2 299 ? 211.723 253.278 373.119 1.00 6.31  ? 299 ILE B CG2 1 
ATOM   3322 C CD1 . ILE B 2 299 ? 214.260 251.679 372.478 1.00 7.59  ? 299 ILE B CD1 1 
ATOM   3323 N N   . LEU B 2 300 ? 211.199 256.779 373.402 1.00 9.05  ? 300 LEU B N   1 
ATOM   3324 C CA  . LEU B 2 300 ? 210.257 257.548 374.197 1.00 8.55  ? 300 LEU B CA  1 
ATOM   3325 C C   . LEU B 2 300 ? 208.839 257.023 374.009 1.00 9.88  ? 300 LEU B C   1 
ATOM   3326 O O   . LEU B 2 300 ? 208.424 256.770 372.875 1.00 14.25 ? 300 LEU B O   1 
ATOM   3327 C CB  . LEU B 2 300 ? 210.289 259.036 373.814 1.00 8.26  ? 300 LEU B CB  1 
ATOM   3328 C CG  . LEU B 2 300 ? 211.573 259.820 374.086 1.00 12.33 ? 300 LEU B CG  1 
ATOM   3329 C CD1 . LEU B 2 300 ? 211.429 261.226 373.546 1.00 13.18 ? 300 LEU B CD1 1 
ATOM   3330 C CD2 . LEU B 2 300 ? 211.904 259.850 375.570 1.00 10.03 ? 300 LEU B CD2 1 
ATOM   3331 N N   . PRO B 2 301 ? 208.065 256.860 375.085 1.00 15.31 ? 301 PRO B N   1 
ATOM   3332 C CA  . PRO B 2 301 ? 206.645 256.533 374.903 1.00 8.63  ? 301 PRO B CA  1 
ATOM   3333 C C   . PRO B 2 301 ? 205.860 257.720 374.371 1.00 9.07  ? 301 PRO B C   1 
ATOM   3334 O O   . PRO B 2 301 ? 205.585 258.672 375.105 1.00 17.49 ? 301 PRO B O   1 
ATOM   3335 C CB  . PRO B 2 301 ? 206.182 256.137 376.313 1.00 11.42 ? 301 PRO B CB  1 
ATOM   3336 C CG  . PRO B 2 301 ? 207.427 255.941 377.108 1.00 9.30  ? 301 PRO B CG  1 
ATOM   3337 C CD  . PRO B 2 301 ? 208.454 256.827 376.502 1.00 10.33 ? 301 PRO B CD  1 
ATOM   3338 N N   . LEU B 2 302 ? 205.502 257.676 373.089 1.00 14.69 ? 302 LEU B N   1 
ATOM   3339 C CA  . LEU B 2 302 ? 204.703 258.746 372.506 1.00 8.49  ? 302 LEU B CA  1 
ATOM   3340 C C   . LEU B 2 302 ? 203.257 258.658 372.969 1.00 7.25  ? 302 LEU B C   1 
ATOM   3341 O O   . LEU B 2 302 ? 202.626 259.683 373.246 1.00 15.28 ? 302 LEU B O   1 
ATOM   3342 C CB  . LEU B 2 302 ? 204.779 258.684 370.982 1.00 6.92  ? 302 LEU B CB  1 
ATOM   3343 C CG  . LEU B 2 302 ? 206.179 258.777 370.377 1.00 11.00 ? 302 LEU B CG  1 
ATOM   3344 C CD1 . LEU B 2 302 ? 206.115 258.605 368.874 1.00 9.82  ? 302 LEU B CD1 1 
ATOM   3345 C CD2 . LEU B 2 302 ? 206.846 260.091 370.742 1.00 7.91  ? 302 LEU B CD2 1 
ATOM   3346 N N   . ALA B 2 303 ? 202.723 257.445 373.056 1.00 11.45 ? 303 ALA B N   1 
ATOM   3347 C CA  . ALA B 2 303 ? 201.425 257.187 373.640 1.00 10.44 ? 303 ALA B CA  1 
ATOM   3348 C C   . ALA B 2 303 ? 201.598 256.221 374.804 1.00 16.19 ? 303 ALA B C   1 
ATOM   3349 O O   . ALA B 2 303 ? 202.233 255.171 374.636 1.00 13.00 ? 303 ALA B O   1 
ATOM   3350 C CB  . ALA B 2 303 ? 200.457 256.599 372.602 1.00 10.10 ? 303 ALA B CB  1 
ATOM   3351 N N   . PRO B 2 304 ? 201.076 256.532 375.988 1.00 14.06 ? 304 PRO B N   1 
ATOM   3352 C CA  . PRO B 2 304 ? 201.321 255.664 377.145 1.00 11.44 ? 304 PRO B CA  1 
ATOM   3353 C C   . PRO B 2 304 ? 200.701 254.285 376.976 1.00 10.16 ? 304 PRO B C   1 
ATOM   3354 O O   . PRO B 2 304 ? 199.663 254.115 376.334 1.00 17.84 ? 304 PRO B O   1 
ATOM   3355 C CB  . PRO B 2 304 ? 200.679 256.430 378.306 1.00 13.00 ? 304 PRO B CB  1 
ATOM   3356 C CG  . PRO B 2 304 ? 199.692 257.331 377.674 1.00 10.62 ? 304 PRO B CG  1 
ATOM   3357 C CD  . PRO B 2 304 ? 200.252 257.697 376.343 1.00 11.97 ? 304 PRO B CD  1 
ATOM   3358 N N   . LEU B 2 305 ? 201.360 253.295 377.570 1.00 13.55 ? 305 LEU B N   1 
ATOM   3359 C CA  . LEU B 2 305 ? 200.879 251.921 377.535 1.00 6.04  ? 305 LEU B CA  1 
ATOM   3360 C C   . LEU B 2 305 ? 199.589 251.793 378.334 1.00 12.56 ? 305 LEU B C   1 
ATOM   3361 O O   . LEU B 2 305 ? 199.459 252.369 379.417 1.00 20.04 ? 305 LEU B O   1 
ATOM   3362 C CB  . LEU B 2 305 ? 201.948 250.991 378.104 1.00 14.89 ? 305 LEU B CB  1 
ATOM   3363 C CG  . LEU B 2 305 ? 201.765 249.486 377.921 1.00 14.53 ? 305 LEU B CG  1 
ATOM   3364 C CD1 . LEU B 2 305 ? 201.926 249.109 376.464 1.00 9.69  ? 305 LEU B CD1 1 
ATOM   3365 C CD2 . LEU B 2 305 ? 202.748 248.725 378.786 1.00 12.98 ? 305 LEU B CD2 1 
ATOM   3366 N N   . ASP B 2 306 ? 198.633 251.034 377.805 1.00 12.67 ? 306 ASP B N   1 
ATOM   3367 C CA  . ASP B 2 306 ? 197.362 250.834 378.483 1.00 14.01 ? 306 ASP B CA  1 
ATOM   3368 C C   . ASP B 2 306 ? 196.809 249.458 378.146 1.00 18.12 ? 306 ASP B C   1 
ATOM   3369 O O   . ASP B 2 306 ? 197.000 248.943 377.041 1.00 19.55 ? 306 ASP B O   1 
ATOM   3370 C CB  . ASP B 2 306 ? 196.350 251.919 378.099 1.00 11.21 ? 306 ASP B CB  1 
ATOM   3371 C CG  . ASP B 2 306 ? 195.294 252.131 379.158 1.00 19.44 ? 306 ASP B CG  1 
ATOM   3372 O OD1 . ASP B 2 306 ? 195.354 251.468 380.213 1.00 25.31 ? 306 ASP B OD1 1 
ATOM   3373 O OD2 . ASP B 2 306 ? 194.397 252.968 378.936 1.00 25.24 ? 306 ASP B OD2 1 
ATOM   3374 N N   . PHE B 2 307 ? 196.118 248.871 379.120 1.00 19.80 ? 307 PHE B N   1 
ATOM   3375 C CA  . PHE B 2 307 ? 195.496 247.563 378.983 1.00 19.23 ? 307 PHE B CA  1 
ATOM   3376 C C   . PHE B 2 307 ? 194.235 247.571 379.837 1.00 23.33 ? 307 PHE B C   1 
ATOM   3377 O O   . PHE B 2 307 ? 194.227 248.138 380.931 1.00 29.17 ? 307 PHE B O   1 
ATOM   3378 C CB  . PHE B 2 307 ? 196.464 246.449 379.403 1.00 20.17 ? 307 PHE B CB  1 
ATOM   3379 C CG  . PHE B 2 307 ? 195.983 245.063 379.081 1.00 18.83 ? 307 PHE B CG  1 
ATOM   3380 C CD1 . PHE B 2 307 ? 195.697 244.697 377.778 1.00 19.73 ? 307 PHE B CD1 1 
ATOM   3381 C CD2 . PHE B 2 307 ? 195.836 244.121 380.080 1.00 16.18 ? 307 PHE B CD2 1 
ATOM   3382 C CE1 . PHE B 2 307 ? 195.262 243.422 377.483 1.00 19.56 ? 307 PHE B CE1 1 
ATOM   3383 C CE2 . PHE B 2 307 ? 195.399 242.846 379.791 1.00 16.86 ? 307 PHE B CE2 1 
ATOM   3384 C CZ  . PHE B 2 307 ? 195.114 242.496 378.492 1.00 15.30 ? 307 PHE B CZ  1 
ATOM   3385 N N   . ALA B 2 308 ? 193.180 246.936 379.336 1.00 29.50 ? 308 ALA B N   1 
ATOM   3386 C CA  . ALA B 2 308 ? 191.831 247.208 379.824 1.00 34.96 ? 308 ALA B CA  1 
ATOM   3387 C C   . ALA B 2 308 ? 191.655 246.835 381.291 1.00 38.11 ? 308 ALA B C   1 
ATOM   3388 O O   . ALA B 2 308 ? 191.775 245.667 381.671 1.00 37.52 ? 308 ALA B O   1 
ATOM   3389 C CB  . ALA B 2 308 ? 190.817 246.452 378.978 1.00 33.85 ? 308 ALA B CB  1 
ATOM   3390 N N   . THR B 2 309 ? 191.328 247.838 382.108 1.00 38.41 ? 309 THR B N   1 
ATOM   3391 C CA  . THR B 2 309 ? 191.010 247.652 383.525 1.00 39.72 ? 309 THR B CA  1 
ATOM   3392 C C   . THR B 2 309 ? 192.173 247.026 384.293 1.00 39.60 ? 309 THR B C   1 
ATOM   3393 O O   . THR B 2 309 ? 191.970 246.322 385.285 1.00 37.05 ? 309 THR B O   1 
ATOM   3394 C CB  . THR B 2 309 ? 189.738 246.813 383.698 1.00 41.75 ? 309 THR B CB  1 
ATOM   3395 O OG1 . THR B 2 309 ? 188.767 247.211 382.724 1.00 41.47 ? 309 THR B OG1 1 
ATOM   3396 C CG2 . THR B 2 309 ? 189.141 247.007 385.089 1.00 37.56 ? 309 THR B CG2 1 
ATOM   3397 N N   . GLU B 2 310 ? 193.402 247.285 383.849 1.00 35.79 ? 310 GLU B N   1 
ATOM   3398 C CA  . GLU B 2 310 ? 194.601 246.836 384.549 1.00 35.87 ? 310 GLU B CA  1 
ATOM   3399 C C   . GLU B 2 310 ? 195.541 248.025 384.692 1.00 41.52 ? 310 GLU B C   1 
ATOM   3400 O O   . GLU B 2 310 ? 196.121 248.481 383.700 1.00 37.81 ? 310 GLU B O   1 
ATOM   3401 C CB  . GLU B 2 310 ? 195.299 245.698 383.803 1.00 34.98 ? 310 GLU B CB  1 
ATOM   3402 C CG  . GLU B 2 310 ? 194.374 244.726 383.091 1.00 35.07 ? 310 GLU B CG  1 
ATOM   3403 C CD  . GLU B 2 310 ? 193.417 244.033 384.027 1.00 38.10 ? 310 GLU B CD  1 
ATOM   3404 O OE1 . GLU B 2 310 ? 193.838 243.668 385.143 1.00 39.31 ? 310 GLU B OE1 1 
ATOM   3405 O OE2 . GLU B 2 310 ? 192.242 243.852 383.647 1.00 40.59 ? 310 GLU B OE2 1 
ATOM   3406 N N   . SER B 2 311 ? 195.683 248.538 385.913 1.00 44.75 ? 311 SER B N   1 
ATOM   3407 C CA  . SER B 2 311 ? 196.770 249.467 386.216 1.00 40.58 ? 311 SER B CA  1 
ATOM   3408 C C   . SER B 2 311 ? 197.989 248.727 386.736 1.00 42.09 ? 311 SER B C   1 
ATOM   3409 O O   . SER B 2 311 ? 198.602 249.115 387.735 1.00 43.85 ? 311 SER B O   1 
ATOM   3410 C CB  . SER B 2 311 ? 196.295 250.508 387.224 1.00 42.24 ? 311 SER B CB  1 
ATOM   3411 O OG  . SER B 2 311 ? 195.760 249.891 388.382 1.00 42.42 ? 311 SER B OG  1 
ATOM   3412 N N   . SER B 2 312 ? 198.355 247.644 386.055 1.00 37.55 ? 312 SER B N   1 
ATOM   3413 C CA  . SER B 2 312 ? 199.526 246.848 386.403 1.00 36.83 ? 312 SER B CA  1 
ATOM   3414 C C   . SER B 2 312 ? 200.316 246.351 385.199 1.00 35.85 ? 312 SER B C   1 
ATOM   3415 O O   . SER B 2 312 ? 201.435 245.863 385.388 1.00 35.76 ? 312 SER B O   1 
ATOM   3416 C CB  . SER B 2 312 ? 199.108 245.647 387.261 1.00 39.16 ? 312 SER B CB  1 
ATOM   3417 O OG  . SER B 2 312 ? 198.131 244.855 386.608 1.00 40.05 ? 312 SER B OG  1 
ATOM   3418 N N   . THR B 2 313 ? 199.784 246.443 383.979 1.00 27.13 ? 313 THR B N   1 
ATOM   3419 C CA  . THR B 2 313 ? 200.408 245.816 382.821 1.00 23.48 ? 313 THR B CA  1 
ATOM   3420 C C   . THR B 2 313 ? 201.814 246.354 382.587 1.00 22.43 ? 313 THR B C   1 
ATOM   3421 O O   . THR B 2 313 ? 202.071 247.553 382.717 1.00 23.94 ? 313 THR B O   1 
ATOM   3422 C CB  . THR B 2 313 ? 199.548 246.034 381.567 1.00 25.22 ? 313 THR B CB  1 
ATOM   3423 O OG1 . THR B 2 313 ? 200.133 245.341 380.458 1.00 21.36 ? 313 THR B OG1 1 
ATOM   3424 C CG2 . THR B 2 313 ? 199.425 247.514 381.221 1.00 26.49 ? 313 THR B CG2 1 
ATOM   3425 N N   . GLU B 2 314 ? 202.721 245.442 382.246 1.00 19.05 ? 314 GLU B N   1 
ATOM   3426 C CA  . GLU B 2 314 ? 204.092 245.763 381.879 1.00 14.83 ? 314 GLU B CA  1 
ATOM   3427 C C   . GLU B 2 314 ? 204.472 244.876 380.709 1.00 12.37 ? 314 GLU B C   1 
ATOM   3428 O O   . GLU B 2 314 ? 204.129 243.692 380.706 1.00 24.09 ? 314 GLU B O   1 
ATOM   3429 C CB  . GLU B 2 314 ? 205.053 245.529 383.046 1.00 15.17 ? 314 GLU B CB  1 
ATOM   3430 C CG  . GLU B 2 314 ? 204.631 246.188 384.334 1.00 20.34 ? 314 GLU B CG  1 
ATOM   3431 C CD  . GLU B 2 314 ? 205.631 245.981 385.452 1.00 28.05 ? 314 GLU B CD  1 
ATOM   3432 O OE1 . GLU B 2 314 ? 206.500 245.097 385.322 1.00 26.84 ? 314 GLU B OE1 1 
ATOM   3433 O OE2 . GLU B 2 314 ? 205.547 246.707 386.464 1.00 30.09 ? 314 GLU B OE2 1 
ATOM   3434 N N   . ILE B 2 315 ? 205.173 245.426 379.723 1.00 8.87  ? 315 ILE B N   1 
ATOM   3435 C CA  . ILE B 2 315 ? 205.602 244.583 378.608 1.00 11.09 ? 315 ILE B CA  1 
ATOM   3436 C C   . ILE B 2 315 ? 207.092 244.785 378.352 1.00 11.99 ? 315 ILE B C   1 
ATOM   3437 O O   . ILE B 2 315 ? 207.606 245.893 378.529 1.00 9.75  ? 315 ILE B O   1 
ATOM   3438 C CB  . ILE B 2 315 ? 204.767 244.850 377.344 1.00 14.72 ? 315 ILE B CB  1 
ATOM   3439 C CG1 . ILE B 2 315 ? 205.125 246.189 376.703 1.00 12.85 ? 315 ILE B CG1 1 
ATOM   3440 C CG2 . ILE B 2 315 ? 203.281 244.807 377.673 1.00 15.26 ? 315 ILE B CG2 1 
ATOM   3441 C CD1 . ILE B 2 315 ? 204.312 246.479 375.475 1.00 17.19 ? 315 ILE B CD1 1 
ATOM   3442 N N   . PRO B 2 316 ? 207.823 243.751 377.945 1.00 19.26 ? 316 PRO B N   1 
ATOM   3443 C CA  . PRO B 2 316 ? 209.266 243.910 377.737 1.00 12.60 ? 316 PRO B CA  1 
ATOM   3444 C C   . PRO B 2 316 ? 209.605 244.517 376.384 1.00 9.71  ? 316 PRO B C   1 
ATOM   3445 O O   . PRO B 2 316 ? 208.907 244.314 375.389 1.00 10.33 ? 316 PRO B O   1 
ATOM   3446 C CB  . PRO B 2 316 ? 209.790 242.474 377.845 1.00 10.14 ? 316 PRO B CB  1 
ATOM   3447 C CG  . PRO B 2 316 ? 208.653 241.634 377.417 1.00 11.46 ? 316 PRO B CG  1 
ATOM   3448 C CD  . PRO B 2 316 ? 207.399 242.346 377.818 1.00 8.07  ? 316 PRO B CD  1 
ATOM   3449 N N   . ILE B 2 317 ? 210.694 245.279 376.365 1.00 10.22 ? 317 ILE B N   1 
ATOM   3450 C CA  . ILE B 2 317 ? 211.312 245.784 375.147 1.00 11.35 ? 317 ILE B CA  1 
ATOM   3451 C C   . ILE B 2 317 ? 212.729 245.235 375.091 1.00 9.09  ? 317 ILE B C   1 
ATOM   3452 O O   . ILE B 2 317 ? 213.474 245.311 376.076 1.00 15.08 ? 317 ILE B O   1 
ATOM   3453 C CB  . ILE B 2 317 ? 211.327 247.326 375.089 1.00 8.88  ? 317 ILE B CB  1 
ATOM   3454 C CG1 . ILE B 2 317 ? 209.926 247.898 375.309 1.00 9.93  ? 317 ILE B CG1 1 
ATOM   3455 C CG2 . ILE B 2 317 ? 211.877 247.798 373.749 1.00 6.32  ? 317 ILE B CG2 1 
ATOM   3456 C CD1 . ILE B 2 317 ? 209.915 249.384 375.610 1.00 15.03 ? 317 ILE B CD1 1 
ATOM   3457 N N   . THR B 2 318 ? 213.096 244.675 373.941 1.00 4.04  ? 318 THR B N   1 
ATOM   3458 C CA  . THR B 2 318 ? 214.405 244.067 373.746 1.00 7.13  ? 318 THR B CA  1 
ATOM   3459 C C   . THR B 2 318 ? 215.096 244.739 372.570 1.00 9.07  ? 318 THR B C   1 
ATOM   3460 O O   . THR B 2 318 ? 214.473 244.973 371.533 1.00 13.46 ? 318 THR B O   1 
ATOM   3461 C CB  . THR B 2 318 ? 214.277 242.556 373.508 1.00 8.90  ? 318 THR B CB  1 
ATOM   3462 O OG1 . THR B 2 318 ? 213.678 241.941 374.655 1.00 13.48 ? 318 THR B OG1 1 
ATOM   3463 C CG2 . THR B 2 318 ? 215.635 241.919 373.254 1.00 11.24 ? 318 THR B CG2 1 
ATOM   3464 N N   . LEU B 2 319 ? 216.374 245.057 372.736 1.00 5.41  ? 319 LEU B N   1 
ATOM   3465 C CA  . LEU B 2 319 ? 217.186 245.636 371.675 1.00 7.88  ? 319 LEU B CA  1 
ATOM   3466 C C   . LEU B 2 319 ? 218.232 244.629 371.223 1.00 9.92  ? 319 LEU B C   1 
ATOM   3467 O O   . LEU B 2 319 ? 218.926 244.035 372.053 1.00 10.49 ? 319 LEU B O   1 
ATOM   3468 C CB  . LEU B 2 319 ? 217.871 246.922 372.141 1.00 14.94 ? 319 LEU B CB  1 
ATOM   3469 C CG  . LEU B 2 319 ? 217.067 248.216 372.014 1.00 13.01 ? 319 LEU B CG  1 
ATOM   3470 C CD1 . LEU B 2 319 ? 216.060 248.349 373.143 1.00 13.72 ? 319 LEU B CD1 1 
ATOM   3471 C CD2 . LEU B 2 319 ? 218.002 249.411 371.975 1.00 10.93 ? 319 LEU B CD2 1 
ATOM   3472 N N   . THR B 2 320 ? 218.340 244.439 369.912 1.00 7.40  ? 320 THR B N   1 
ATOM   3473 C CA  . THR B 2 320 ? 219.381 243.614 369.313 1.00 8.28  ? 320 THR B CA  1 
ATOM   3474 C C   . THR B 2 320 ? 220.125 244.467 368.297 1.00 10.82 ? 320 THR B C   1 
ATOM   3475 O O   . THR B 2 320 ? 219.517 244.998 367.365 1.00 11.64 ? 320 THR B O   1 
ATOM   3476 C CB  . THR B 2 320 ? 218.790 242.366 368.653 1.00 12.76 ? 320 THR B CB  1 
ATOM   3477 O OG1 . THR B 2 320 ? 218.008 241.646 369.611 1.00 15.58 ? 320 THR B OG1 1 
ATOM   3478 C CG2 . THR B 2 320 ? 219.890 241.452 368.133 1.00 11.44 ? 320 THR B CG2 1 
ATOM   3479 N N   . ILE B 2 321 ? 221.435 244.593 368.475 1.00 11.12 ? 321 ILE B N   1 
ATOM   3480 C CA  . ILE B 2 321 ? 222.248 245.525 367.704 1.00 10.80 ? 321 ILE B CA  1 
ATOM   3481 C C   . ILE B 2 321 ? 223.380 244.748 367.050 1.00 9.02  ? 321 ILE B C   1 
ATOM   3482 O O   . ILE B 2 321 ? 224.091 243.998 367.723 1.00 18.68 ? 321 ILE B O   1 
ATOM   3483 C CB  . ILE B 2 321 ? 222.796 246.664 368.580 1.00 15.05 ? 321 ILE B CB  1 
ATOM   3484 C CG1 . ILE B 2 321 ? 221.634 247.450 369.197 1.00 13.93 ? 321 ILE B CG1 1 
ATOM   3485 C CG2 . ILE B 2 321 ? 223.688 247.585 367.763 1.00 14.11 ? 321 ILE B CG2 1 
ATOM   3486 C CD1 . ILE B 2 321 ? 222.043 248.425 370.269 1.00 15.41 ? 321 ILE B CD1 1 
ATOM   3487 N N   . ALA B 2 322 ? 223.528 244.909 365.739 1.00 8.60  ? 322 ALA B N   1 
ATOM   3488 C CA  . ALA B 2 322 ? 224.627 244.302 365.010 1.00 9.44  ? 322 ALA B CA  1 
ATOM   3489 C C   . ALA B 2 322 ? 225.530 245.385 364.446 1.00 17.88 ? 322 ALA B C   1 
ATOM   3490 O O   . ALA B 2 322 ? 225.068 246.173 363.612 1.00 10.85 ? 322 ALA B O   1 
ATOM   3491 C CB  . ALA B 2 322 ? 224.107 243.427 363.880 1.00 7.40  ? 322 ALA B CB  1 
ATOM   3492 N N   . PRO B 2 323 ? 226.794 245.481 364.852 1.00 17.03 ? 323 PRO B N   1 
ATOM   3493 C CA  . PRO B 2 323 ? 227.714 246.362 364.128 1.00 14.91 ? 323 PRO B CA  1 
ATOM   3494 C C   . PRO B 2 323 ? 227.981 245.838 362.725 1.00 13.34 ? 323 PRO B C   1 
ATOM   3495 O O   . PRO B 2 323 ? 227.971 244.631 362.477 1.00 22.02 ? 323 PRO B O   1 
ATOM   3496 C CB  . PRO B 2 323 ? 228.977 246.359 364.996 1.00 13.75 ? 323 PRO B CB  1 
ATOM   3497 C CG  . PRO B 2 323 ? 228.862 245.171 365.855 1.00 13.81 ? 323 PRO B CG  1 
ATOM   3498 C CD  . PRO B 2 323 ? 227.413 244.915 366.060 1.00 14.30 ? 323 PRO B CD  1 
ATOM   3499 N N   . MET B 2 324 ? 228.212 246.766 361.806 1.00 17.77 ? 324 MET B N   1 
ATOM   3500 C CA  . MET B 2 324 ? 228.361 246.470 360.392 1.00 17.15 ? 324 MET B CA  1 
ATOM   3501 C C   . MET B 2 324 ? 229.544 247.244 359.839 1.00 16.77 ? 324 MET B C   1 
ATOM   3502 O O   . MET B 2 324 ? 229.923 248.288 360.375 1.00 20.04 ? 324 MET B O   1 
ATOM   3503 C CB  . MET B 2 324 ? 227.109 246.851 359.592 1.00 18.40 ? 324 MET B CB  1 
ATOM   3504 C CG  . MET B 2 324 ? 225.793 246.571 360.283 1.00 19.38 ? 324 MET B CG  1 
ATOM   3505 S SD  . MET B 2 324 ? 224.392 246.798 359.172 1.00 43.16 ? 324 MET B SD  1 
ATOM   3506 C CE  . MET B 2 324 ? 224.642 245.436 358.037 1.00 25.93 ? 324 MET B CE  1 
ATOM   3507 N N   . CYS B 2 325 ? 230.118 246.725 358.755 1.00 23.32 ? 325 CYS B N   1 
ATOM   3508 C CA  . CYS B 2 325 ? 231.200 247.396 358.039 1.00 21.70 ? 325 CYS B CA  1 
ATOM   3509 C C   . CYS B 2 325 ? 232.282 247.853 359.012 1.00 18.48 ? 325 CYS B C   1 
ATOM   3510 O O   . CYS B 2 325 ? 232.735 248.998 358.992 1.00 21.11 ? 325 CYS B O   1 
ATOM   3511 C CB  . CYS B 2 325 ? 230.663 248.568 357.219 1.00 20.53 ? 325 CYS B CB  1 
ATOM   3512 S SG  . CYS B 2 325 ? 229.479 248.091 355.939 1.00 39.51 ? 325 CYS B SG  1 
ATOM   3513 N N   . CYS B 2 326 ? 232.686 246.936 359.880 1.00 17.81 ? 326 CYS B N   1 
ATOM   3514 C CA  . CYS B 2 326 ? 233.594 247.259 360.966 1.00 16.23 ? 326 CYS B CA  1 
ATOM   3515 C C   . CYS B 2 326 ? 235.029 247.364 360.469 1.00 16.95 ? 326 CYS B C   1 
ATOM   3516 O O   . CYS B 2 326 ? 235.473 246.576 359.630 1.00 22.91 ? 326 CYS B O   1 
ATOM   3517 C CB  . CYS B 2 326 ? 233.497 246.195 362.056 1.00 17.81 ? 326 CYS B CB  1 
ATOM   3518 S SG  . CYS B 2 326 ? 231.828 245.976 362.687 1.00 29.47 ? 326 CYS B SG  1 
ATOM   3519 N N   . GLU B 2 327 ? 235.750 248.351 360.990 1.00 14.85 ? 327 GLU B N   1 
ATOM   3520 C CA  . GLU B 2 327 ? 237.172 248.500 360.725 1.00 11.22 ? 327 GLU B CA  1 
ATOM   3521 C C   . GLU B 2 327 ? 237.872 248.870 362.018 1.00 10.67 ? 327 GLU B C   1 
ATOM   3522 O O   . GLU B 2 327 ? 237.357 249.668 362.804 1.00 18.09 ? 327 GLU B O   1 
ATOM   3523 C CB  . GLU B 2 327 ? 237.451 249.567 359.663 1.00 14.82 ? 327 GLU B CB  1 
ATOM   3524 C CG  . GLU B 2 327 ? 237.076 249.154 358.256 1.00 19.86 ? 327 GLU B CG  1 
ATOM   3525 C CD  . GLU B 2 327 ? 237.486 250.180 357.221 1.00 27.66 ? 327 GLU B CD  1 
ATOM   3526 O OE1 . GLU B 2 327 ? 237.666 251.359 357.591 1.00 28.97 ? 327 GLU B OE1 1 
ATOM   3527 O OE2 . GLU B 2 327 ? 237.636 249.809 356.038 1.00 30.99 ? 327 GLU B OE2 1 
ATOM   3528 N N   . PHE B 2 328 ? 239.042 248.280 362.233 1.00 11.27 ? 328 PHE B N   1 
ATOM   3529 C CA  . PHE B 2 328 ? 239.872 248.561 363.392 1.00 8.50  ? 328 PHE B CA  1 
ATOM   3530 C C   . PHE B 2 328 ? 241.300 248.798 362.931 1.00 9.38  ? 328 PHE B C   1 
ATOM   3531 O O   . PHE B 2 328 ? 241.751 248.208 361.946 1.00 11.22 ? 328 PHE B O   1 
ATOM   3532 C CB  . PHE B 2 328 ? 239.826 247.417 364.401 1.00 11.99 ? 328 PHE B CB  1 
ATOM   3533 C CG  . PHE B 2 328 ? 238.458 247.146 364.948 1.00 14.15 ? 328 PHE B CG  1 
ATOM   3534 C CD1 . PHE B 2 328 ? 237.963 247.885 366.004 1.00 11.55 ? 328 PHE B CD1 1 
ATOM   3535 C CD2 . PHE B 2 328 ? 237.666 246.147 364.408 1.00 14.27 ? 328 PHE B CD2 1 
ATOM   3536 C CE1 . PHE B 2 328 ? 236.706 247.638 366.509 1.00 9.95  ? 328 PHE B CE1 1 
ATOM   3537 C CE2 . PHE B 2 328 ? 236.412 245.898 364.909 1.00 11.24 ? 328 PHE B CE2 1 
ATOM   3538 C CZ  . PHE B 2 328 ? 235.932 246.644 365.963 1.00 10.30 ? 328 PHE B CZ  1 
ATOM   3539 N N   . ASN B 2 329 ? 242.005 249.673 363.639 1.00 14.28 ? 329 ASN B N   1 
ATOM   3540 C CA  . ASN B 2 329 ? 243.372 250.008 363.279 1.00 7.14  ? 329 ASN B CA  1 
ATOM   3541 C C   . ASN B 2 329 ? 244.100 250.481 364.524 1.00 4.91  ? 329 ASN B C   1 
ATOM   3542 O O   . ASN B 2 329 ? 243.501 251.086 365.415 1.00 10.57 ? 329 ASN B O   1 
ATOM   3543 C CB  . ASN B 2 329 ? 243.411 251.083 362.187 1.00 7.54  ? 329 ASN B CB  1 
ATOM   3544 C CG  . ASN B 2 329 ? 244.746 251.150 361.480 1.00 15.44 ? 329 ASN B CG  1 
ATOM   3545 O OD1 . ASN B 2 329 ? 245.514 250.190 361.486 1.00 22.20 ? 329 ASN B OD1 1 
ATOM   3546 N ND2 . ASN B 2 329 ? 245.029 252.285 360.861 1.00 16.06 ? 329 ASN B ND2 1 
ATOM   3547 N N   . GLY B 2 330 ? 245.396 250.189 364.584 1.00 8.10  ? 330 GLY B N   1 
ATOM   3548 C CA  . GLY B 2 330 ? 246.213 250.640 365.691 1.00 3.39  ? 330 GLY B CA  1 
ATOM   3549 C C   . GLY B 2 330 ? 246.267 249.653 366.834 1.00 0.77  ? 330 GLY B C   1 
ATOM   3550 O O   . GLY B 2 330 ? 245.975 250.003 367.979 1.00 6.82  ? 330 GLY B O   1 
ATOM   3551 N N   . LEU B 2 331 ? 246.642 248.414 366.534 1.00 7.65  ? 331 LEU B N   1 
ATOM   3552 C CA  . LEU B 2 331 ? 246.699 247.377 367.553 1.00 4.29  ? 331 LEU B CA  1 
ATOM   3553 C C   . LEU B 2 331 ? 247.811 247.669 368.554 1.00 6.24  ? 331 LEU B C   1 
ATOM   3554 O O   . LEU B 2 331 ? 248.952 247.939 368.172 1.00 14.04 ? 331 LEU B O   1 
ATOM   3555 C CB  . LEU B 2 331 ? 246.915 246.017 366.896 1.00 8.60  ? 331 LEU B CB  1 
ATOM   3556 C CG  . LEU B 2 331 ? 246.912 244.796 367.815 1.00 10.43 ? 331 LEU B CG  1 
ATOM   3557 C CD1 . LEU B 2 331 ? 245.562 244.622 368.493 1.00 7.73  ? 331 LEU B CD1 1 
ATOM   3558 C CD2 . LEU B 2 331 ? 247.279 243.562 367.022 1.00 12.16 ? 331 LEU B CD2 1 
ATOM   3559 N N   . ARG B 2 332 ? 247.472 247.620 369.835 1.00 5.24  ? 332 ARG B N   1 
ATOM   3560 C CA  . ARG B 2 332 ? 248.413 247.857 370.923 1.00 5.92  ? 332 ARG B CA  1 
ATOM   3561 C C   . ARG B 2 332 ? 247.939 247.040 372.121 1.00 6.98  ? 332 ARG B C   1 
ATOM   3562 O O   . ARG B 2 332 ? 247.106 246.141 371.978 1.00 11.29 ? 332 ARG B O   1 
ATOM   3563 C CB  . ARG B 2 332 ? 248.524 249.364 371.220 1.00 6.54  ? 332 ARG B CB  1 
ATOM   3564 C CG  . ARG B 2 332 ? 247.206 250.113 371.122 1.00 9.24  ? 332 ARG B CG  1 
ATOM   3565 C CD  . ARG B 2 332 ? 246.966 250.998 372.316 1.00 7.93  ? 332 ARG B CD  1 
ATOM   3566 N NE  . ARG B 2 332 ? 245.744 251.779 372.167 1.00 11.12 ? 332 ARG B NE  1 
ATOM   3567 C CZ  . ARG B 2 332 ? 244.526 251.328 372.428 1.00 7.80  ? 332 ARG B CZ  1 
ATOM   3568 N NH1 . ARG B 2 332 ? 244.320 250.089 372.840 1.00 11.08 ? 332 ARG B NH1 1 
ATOM   3569 N NH2 . ARG B 2 332 ? 243.488 252.142 372.275 1.00 7.01  ? 332 ARG B NH2 1 
ATOM   3570 N N   . ASN B 2 333 ? 248.467 247.345 373.302 1.00 7.43  ? 333 ASN B N   1 
ATOM   3571 C CA  . ASN B 2 333 ? 247.996 246.681 374.504 1.00 6.14  ? 333 ASN B CA  1 
ATOM   3572 C C   . ASN B 2 333 ? 246.563 247.114 374.818 1.00 10.98 ? 333 ASN B C   1 
ATOM   3573 O O   . ASN B 2 333 ? 246.034 248.079 374.261 1.00 16.92 ? 333 ASN B O   1 
ATOM   3574 C CB  . ASN B 2 333 ? 248.932 246.965 375.680 1.00 8.67  ? 333 ASN B CB  1 
ATOM   3575 C CG  . ASN B 2 333 ? 249.195 248.440 375.882 1.00 12.72 ? 333 ASN B CG  1 
ATOM   3576 O OD1 . ASN B 2 333 ? 249.454 249.174 374.931 1.00 13.88 ? 333 ASN B OD1 1 
ATOM   3577 N ND2 . ASN B 2 333 ? 249.132 248.884 377.127 1.00 17.10 ? 333 ASN B ND2 1 
ATOM   3578 N N   . ILE B 2 334 ? 245.932 246.377 375.723 1.00 12.61 ? 334 ILE B N   1 
ATOM   3579 C CA  . ILE B 2 334 ? 244.499 246.499 375.970 1.00 9.81  ? 334 ILE B CA  1 
ATOM   3580 C C   . ILE B 2 334 ? 244.202 247.770 376.755 1.00 10.45 ? 334 ILE B C   1 
ATOM   3581 O O   . ILE B 2 334 ? 244.908 248.115 377.709 1.00 10.23 ? 334 ILE B O   1 
ATOM   3582 C CB  . ILE B 2 334 ? 243.978 245.250 376.709 1.00 9.39  ? 334 ILE B CB  1 
ATOM   3583 C CG1 . ILE B 2 334 ? 242.454 245.278 376.835 1.00 11.15 ? 334 ILE B CG1 1 
ATOM   3584 C CG2 . ILE B 2 334 ? 244.587 245.145 378.093 1.00 11.04 ? 334 ILE B CG2 1 
ATOM   3585 C CD1 . ILE B 2 334 ? 241.730 245.010 375.554 1.00 11.67 ? 334 ILE B CD1 1 
ATOM   3586 N N   . THR B 2 335 ? 243.144 248.470 376.350 1.00 11.84 ? 335 THR B N   1 
ATOM   3587 C CA  . THR B 2 335 ? 242.621 249.596 377.110 1.00 11.71 ? 335 THR B CA  1 
ATOM   3588 C C   . THR B 2 335 ? 241.679 249.092 378.195 1.00 11.73 ? 335 THR B C   1 
ATOM   3589 O O   . THR B 2 335 ? 240.780 248.292 377.923 1.00 16.20 ? 335 THR B O   1 
ATOM   3590 C CB  . THR B 2 335 ? 241.877 250.567 376.190 1.00 13.39 ? 335 THR B CB  1 
ATOM   3591 O OG1 . THR B 2 335 ? 242.806 251.213 375.315 1.00 18.32 ? 335 THR B OG1 1 
ATOM   3592 C CG2 . THR B 2 335 ? 241.127 251.616 376.997 1.00 8.11  ? 335 THR B CG2 1 
ATOM   3593 N N   . VAL B 2 336 ? 241.881 249.557 379.419 1.00 11.82 ? 336 VAL B N   1 
ATOM   3594 C CA  . VAL B 2 336 ? 241.048 249.193 380.555 1.00 10.49 ? 336 VAL B CA  1 
ATOM   3595 C C   . VAL B 2 336 ? 240.494 250.475 381.165 1.00 11.37 ? 336 VAL B C   1 
ATOM   3596 O O   . VAL B 2 336 ? 241.108 251.070 382.049 1.00 13.17 ? 336 VAL B O   1 
ATOM   3597 C CB  . VAL B 2 336 ? 241.837 248.377 381.596 1.00 12.88 ? 336 VAL B CB  1 
ATOM   3598 C CG1 . VAL B 2 336 ? 240.895 247.774 382.624 1.00 9.75  ? 336 VAL B CG1 1 
ATOM   3599 C CG2 . VAL B 2 336 ? 242.653 247.292 380.916 1.00 11.52 ? 336 VAL B CG2 1 
ATOM   3600 N N   . PRO B 2 337 ? 239.333 250.938 380.708 1.00 17.94 ? 337 PRO B N   1 
ATOM   3601 C CA  . PRO B 2 337 ? 238.780 252.184 381.246 1.00 16.15 ? 337 PRO B CA  1 
ATOM   3602 C C   . PRO B 2 337 ? 238.460 252.067 382.724 1.00 18.79 ? 337 PRO B C   1 
ATOM   3603 O O   . PRO B 2 337 ? 238.095 251.003 383.227 1.00 22.70 ? 337 PRO B O   1 
ATOM   3604 C CB  . PRO B 2 337 ? 237.504 252.398 380.421 1.00 14.16 ? 337 PRO B CB  1 
ATOM   3605 C CG  . PRO B 2 337 ? 237.667 251.548 379.215 1.00 15.92 ? 337 PRO B CG  1 
ATOM   3606 C CD  . PRO B 2 337 ? 238.480 250.375 379.649 1.00 13.69 ? 337 PRO B CD  1 
ATOM   3607 N N   . ARG B 2 338 ? 238.601 253.188 383.423 1.00 25.28 ? 338 ARG B N   1 
ATOM   3608 C CA  . ARG B 2 338 ? 238.234 253.231 384.829 1.00 24.66 ? 338 ARG B CA  1 
ATOM   3609 C C   . ARG B 2 338 ? 236.728 253.078 384.982 1.00 25.80 ? 338 ARG B C   1 
ATOM   3610 O O   . ARG B 2 338 ? 235.947 253.626 384.200 1.00 26.35 ? 338 ARG B O   1 
ATOM   3611 C CB  . ARG B 2 338 ? 238.695 254.543 385.456 1.00 23.62 ? 338 ARG B CB  1 
ATOM   3612 C CG  . ARG B 2 338 ? 238.504 254.613 386.955 1.00 26.21 ? 338 ARG B CG  1 
ATOM   3613 C CD  . ARG B 2 338 ? 238.920 255.967 387.487 1.00 26.74 ? 338 ARG B CD  1 
ATOM   3614 N NE  . ARG B 2 338 ? 238.030 257.025 387.028 1.00 27.32 ? 338 ARG B NE  1 
ATOM   3615 C CZ  . ARG B 2 338 ? 238.334 258.315 387.027 1.00 27.34 ? 338 ARG B CZ  1 
ATOM   3616 N NH1 . ARG B 2 338 ? 239.516 258.748 387.432 1.00 24.19 ? 338 ARG B NH1 1 
ATOM   3617 N NH2 . ARG B 2 338 ? 237.430 259.194 386.602 1.00 27.66 ? 338 ARG B NH2 1 
ATOM   3618 N N   . THR B 2 339 ? 236.322 252.320 385.993 1.00 29.59 ? 339 THR B N   1 
ATOM   3619 C CA  . THR B 2 339 ? 234.920 252.127 386.325 1.00 32.26 ? 339 THR B CA  1 
ATOM   3620 C C   . THR B 2 339 ? 234.643 252.733 387.694 1.00 32.90 ? 339 THR B C   1 
ATOM   3621 O O   . THR B 2 339 ? 235.559 253.104 388.432 1.00 31.78 ? 339 THR B O   1 
ATOM   3622 C CB  . THR B 2 339 ? 234.542 250.640 386.304 1.00 30.76 ? 339 THR B CB  1 
ATOM   3623 O OG1 . THR B 2 339 ? 235.411 249.906 387.174 1.00 31.41 ? 339 THR B OG1 1 
ATOM   3624 C CG2 . THR B 2 339 ? 234.649 250.082 384.890 1.00 27.39 ? 339 THR B CG2 1 
ATOM   3625 N N   . GLN B 2 340 ? 233.362 252.836 388.026 1.00 33.78 ? 340 GLN B N   1 
ATOM   3626 C CA  . GLN B 2 340 ? 232.945 253.523 389.242 1.00 33.23 ? 340 GLN B CA  1 
ATOM   3627 C C   . GLN B 2 340 ? 232.427 252.545 390.295 1.00 37.30 ? 340 GLN B C   1 
ATOM   3628 O O   . GLN B 2 340 ? 233.047 252.352 391.340 1.00 31.66 ? 340 GLN B O   1 
ATOM   3629 C CB  . GLN B 2 340 ? 231.870 254.555 388.912 1.00 29.44 ? 340 GLN B CB  1 
ATOM   3630 C CG  . GLN B 2 340 ? 231.791 255.702 389.899 1.00 32.35 ? 340 GLN B CG  1 
ATOM   3631 C CD  . GLN B 2 340 ? 230.864 256.815 389.448 1.00 35.18 ? 340 GLN B CD  1 
ATOM   3632 O OE1 . GLN B 2 340 ? 230.972 257.948 389.916 1.00 35.37 ? 340 GLN B OE1 1 
ATOM   3633 N NE2 . GLN B 2 340 ? 229.944 256.501 388.541 1.00 33.09 ? 340 GLN B NE2 1 
ATOM   3634 O OXT . GLN B 2 340 ? 231.377 251.925 390.127 1.00 37.56 ? 340 GLN B OXT 1 
ATOM   3635 N N   . GLY C 3 1   ? 246.937 308.804 339.555 1.00 13.41 ? 1   GLY C N   1 
ATOM   3636 C CA  . GLY C 3 1   ? 246.482 307.480 339.048 1.00 5.31  ? 1   GLY C CA  1 
ATOM   3637 C C   . GLY C 3 1   ? 245.255 307.586 338.168 1.00 6.04  ? 1   GLY C C   1 
ATOM   3638 O O   . GLY C 3 1   ? 245.032 308.607 337.525 1.00 17.40 ? 1   GLY C O   1 
ATOM   3639 N N   . LEU C 3 2   ? 244.469 306.520 338.135 1.00 10.74 ? 2   LEU C N   1 
ATOM   3640 C CA  . LEU C 3 2   ? 243.220 306.527 337.386 1.00 2.99  ? 2   LEU C CA  1 
ATOM   3641 C C   . LEU C 3 2   ? 242.219 307.462 338.059 1.00 8.57  ? 2   LEU C C   1 
ATOM   3642 O O   . LEU C 3 2   ? 242.003 307.356 339.270 1.00 11.49 ? 2   LEU C O   1 
ATOM   3643 C CB  . LEU C 3 2   ? 242.652 305.114 337.307 1.00 7.73  ? 2   LEU C CB  1 
ATOM   3644 C CG  . LEU C 3 2   ? 241.316 304.933 336.588 1.00 13.04 ? 2   LEU C CG  1 
ATOM   3645 C CD1 . LEU C 3 2   ? 241.479 305.070 335.085 1.00 8.77  ? 2   LEU C CD1 1 
ATOM   3646 C CD2 . LEU C 3 2   ? 240.714 303.591 336.943 1.00 6.80  ? 2   LEU C CD2 1 
ATOM   3647 N N   . PRO C 3 3   ? 241.596 308.385 337.326 1.00 13.86 ? 3   PRO C N   1 
ATOM   3648 C CA  . PRO C 3 3   ? 240.595 309.257 337.957 1.00 9.00  ? 3   PRO C CA  1 
ATOM   3649 C C   . PRO C 3 3   ? 239.392 308.457 338.437 1.00 7.19  ? 3   PRO C C   1 
ATOM   3650 O O   . PRO C 3 3   ? 238.780 307.707 337.675 1.00 10.05 ? 3   PRO C O   1 
ATOM   3651 C CB  . PRO C 3 3   ? 240.218 310.236 336.838 1.00 1.53  ? 3   PRO C CB  1 
ATOM   3652 C CG  . PRO C 3 3   ? 241.314 310.146 335.848 1.00 5.29  ? 3   PRO C CG  1 
ATOM   3653 C CD  . PRO C 3 3   ? 241.822 308.749 335.918 1.00 5.32  ? 3   PRO C CD  1 
ATOM   3654 N N   . VAL C 3 4   ? 239.057 308.623 339.716 1.00 2.78  ? 4   VAL C N   1 
ATOM   3655 C CA  . VAL C 3 4   ? 237.953 307.909 340.340 1.00 0.74  ? 4   VAL C CA  1 
ATOM   3656 C C   . VAL C 3 4   ? 237.113 308.897 341.135 1.00 5.76  ? 4   VAL C C   1 
ATOM   3657 O O   . VAL C 3 4   ? 237.578 309.963 341.541 1.00 3.85  ? 4   VAL C O   1 
ATOM   3658 C CB  . VAL C 3 4   ? 238.431 306.752 341.255 1.00 3.88  ? 4   VAL C CB  1 
ATOM   3659 C CG1 . VAL C 3 4   ? 239.140 305.688 340.441 1.00 0.98  ? 4   VAL C CG1 1 
ATOM   3660 C CG2 . VAL C 3 4   ? 239.327 307.269 342.372 1.00 0.01  ? 4   VAL C CG2 1 
ATOM   3661 N N   . LEU C 3 5   ? 235.856 308.519 341.362 1.00 7.15  ? 5   LEU C N   1 
ATOM   3662 C CA  . LEU C 3 5   ? 234.906 309.349 342.091 1.00 4.64  ? 5   LEU C CA  1 
ATOM   3663 C C   . LEU C 3 5   ? 234.154 308.467 343.077 1.00 1.99  ? 5   LEU C C   1 
ATOM   3664 O O   . LEU C 3 5   ? 233.511 307.494 342.675 1.00 6.43  ? 5   LEU C O   1 
ATOM   3665 C CB  . LEU C 3 5   ? 233.944 310.049 341.123 1.00 7.23  ? 5   LEU C CB  1 
ATOM   3666 C CG  . LEU C 3 5   ? 233.080 311.185 341.679 1.00 3.19  ? 5   LEU C CG  1 
ATOM   3667 C CD1 . LEU C 3 5   ? 232.680 312.144 340.576 1.00 8.78  ? 5   LEU C CD1 1 
ATOM   3668 C CD2 . LEU C 3 5   ? 231.843 310.643 342.368 1.00 12.02 ? 5   LEU C CD2 1 
ATOM   3669 N N   . ASN C 3 6   ? 234.227 308.813 344.359 1.00 9.50  ? 6   ASN C N   1 
ATOM   3670 C CA  . ASN C 3 6   ? 233.626 308.005 345.417 1.00 3.25  ? 6   ASN C CA  1 
ATOM   3671 C C   . ASN C 3 6   ? 232.129 308.273 345.475 1.00 4.24  ? 6   ASN C C   1 
ATOM   3672 O O   . ASN C 3 6   ? 231.700 309.377 345.822 1.00 20.56 ? 6   ASN C O   1 
ATOM   3673 C CB  . ASN C 3 6   ? 234.284 308.312 346.758 1.00 4.50  ? 6   ASN C CB  1 
ATOM   3674 C CG  . ASN C 3 6   ? 235.721 307.854 346.817 1.00 0.27  ? 6   ASN C CG  1 
ATOM   3675 O OD1 . ASN C 3 6   ? 236.004 306.709 347.153 1.00 8.86  ? 6   ASN C OD1 1 
ATOM   3676 N ND2 . ASN C 3 6   ? 236.637 308.748 346.490 1.00 9.21  ? 6   ASN C ND2 1 
ATOM   3677 N N   . THR C 3 7   ? 231.337 307.263 345.138 1.00 10.74 ? 7   THR C N   1 
ATOM   3678 C CA  . THR C 3 7   ? 229.890 307.357 345.171 1.00 5.92  ? 7   THR C CA  1 
ATOM   3679 C C   . THR C 3 7   ? 229.375 307.212 346.598 1.00 3.49  ? 7   THR C C   1 
ATOM   3680 O O   . THR C 3 7   ? 230.080 306.714 347.475 1.00 15.20 ? 7   THR C O   1 
ATOM   3681 C CB  . THR C 3 7   ? 229.272 306.276 344.291 1.00 0.98  ? 7   THR C CB  1 
ATOM   3682 O OG1 . THR C 3 7   ? 229.475 304.992 344.893 1.00 9.61  ? 7   THR C OG1 1 
ATOM   3683 C CG2 . THR C 3 7   ? 229.894 306.288 342.910 1.00 0.01  ? 7   THR C CG2 1 
ATOM   3684 N N   . PRO C 3 8   ? 228.144 307.648 346.862 1.00 12.49 ? 8   PRO C N   1 
ATOM   3685 C CA  . PRO C 3 8   ? 227.563 307.430 348.191 1.00 14.75 ? 8   PRO C CA  1 
ATOM   3686 C C   . PRO C 3 8   ? 227.440 305.947 348.511 1.00 8.49  ? 8   PRO C C   1 
ATOM   3687 O O   . PRO C 3 8   ? 227.246 305.107 347.631 1.00 9.51  ? 8   PRO C O   1 
ATOM   3688 C CB  . PRO C 3 8   ? 226.191 308.113 348.101 1.00 9.80  ? 8   PRO C CB  1 
ATOM   3689 C CG  . PRO C 3 8   ? 225.947 308.334 346.659 1.00 2.20  ? 8   PRO C CG  1 
ATOM   3690 C CD  . PRO C 3 8   ? 227.264 308.453 346.001 1.00 2.14  ? 8   PRO C CD  1 
ATOM   3691 N N   . GLY C 3 9   ? 227.559 305.633 349.799 1.00 13.48 ? 9   GLY C N   1 
ATOM   3692 C CA  . GLY C 3 9   ? 227.703 304.270 350.256 1.00 0.01  ? 9   GLY C CA  1 
ATOM   3693 C C   . GLY C 3 9   ? 229.134 303.826 350.459 1.00 4.55  ? 9   GLY C C   1 
ATOM   3694 O O   . GLY C 3 9   ? 229.357 302.708 350.935 1.00 7.37  ? 9   GLY C O   1 
ATOM   3695 N N   . SER C 3 10  ? 230.110 304.659 350.104 1.00 10.85 ? 10  SER C N   1 
ATOM   3696 C CA  . SER C 3 10  ? 231.507 304.339 350.353 1.00 3.69  ? 10  SER C CA  1 
ATOM   3697 C C   . SER C 3 10  ? 231.794 304.335 351.848 1.00 5.58  ? 10  SER C C   1 
ATOM   3698 O O   . SER C 3 10  ? 231.317 305.196 352.589 1.00 16.89 ? 10  SER C O   1 
ATOM   3699 C CB  . SER C 3 10  ? 232.418 305.349 349.656 1.00 4.81  ? 10  SER C CB  1 
ATOM   3700 O OG  . SER C 3 10  ? 232.325 305.247 348.249 1.00 2.45  ? 10  SER C OG  1 
ATOM   3701 N N   . ASN C 3 11  ? 232.579 303.352 352.285 1.00 6.91  ? 11  ASN C N   1 
ATOM   3702 C CA  . ASN C 3 11  ? 233.045 303.181 353.658 1.00 1.72  ? 11  ASN C CA  1 
ATOM   3703 C C   . ASN C 3 11  ? 231.965 302.657 354.594 1.00 7.40  ? 11  ASN C C   1 
ATOM   3704 O O   . ASN C 3 11  ? 232.199 302.605 355.804 1.00 16.08 ? 11  ASN C O   1 
ATOM   3705 C CB  . ASN C 3 11  ? 233.608 304.480 354.244 1.00 2.77  ? 11  ASN C CB  1 
ATOM   3706 C CG  . ASN C 3 11  ? 234.760 305.034 353.433 1.00 5.66  ? 11  ASN C CG  1 
ATOM   3707 O OD1 . ASN C 3 11  ? 235.456 304.300 352.739 1.00 13.06 ? 11  ASN C OD1 1 
ATOM   3708 N ND2 . ASN C 3 11  ? 234.967 306.337 353.520 1.00 8.50  ? 11  ASN C ND2 1 
ATOM   3709 N N   . GLN C 3 12  ? 230.800 302.270 354.089 1.00 11.84 ? 12  GLN C N   1 
ATOM   3710 C CA  . GLN C 3 12  ? 229.770 301.683 354.930 1.00 8.09  ? 12  GLN C CA  1 
ATOM   3711 C C   . GLN C 3 12  ? 230.011 300.186 355.097 1.00 9.20  ? 12  GLN C C   1 
ATOM   3712 O O   . GLN C 3 12  ? 230.637 299.533 354.261 1.00 11.01 ? 12  GLN C O   1 
ATOM   3713 C CB  . GLN C 3 12  ? 228.379 301.927 354.342 1.00 0.80  ? 12  GLN C CB  1 
ATOM   3714 C CG  . GLN C 3 12  ? 227.994 300.996 353.196 1.00 0.01  ? 12  GLN C CG  1 
ATOM   3715 C CD  . GLN C 3 12  ? 226.731 301.436 352.490 1.00 0.01  ? 12  GLN C CD  1 
ATOM   3716 O OE1 . GLN C 3 12  ? 226.141 302.456 352.833 1.00 11.65 ? 12  GLN C OE1 1 
ATOM   3717 N NE2 . GLN C 3 12  ? 226.307 300.668 351.502 1.00 4.66  ? 12  GLN C NE2 1 
ATOM   3718 N N   . TYR C 3 13  ? 229.506 299.646 356.202 1.00 2.49  ? 13  TYR C N   1 
ATOM   3719 C CA  . TYR C 3 13  ? 229.484 298.208 356.435 1.00 2.16  ? 13  TYR C CA  1 
ATOM   3720 C C   . TYR C 3 13  ? 228.030 297.750 356.440 1.00 4.61  ? 13  TYR C C   1 
ATOM   3721 O O   . TYR C 3 13  ? 227.285 298.026 357.385 1.00 0.01  ? 13  TYR C O   1 
ATOM   3722 C CB  . TYR C 3 13  ? 230.188 297.841 357.742 1.00 3.48  ? 13  TYR C CB  1 
ATOM   3723 C CG  . TYR C 3 13  ? 230.026 296.386 358.129 1.00 4.00  ? 13  TYR C CG  1 
ATOM   3724 C CD1 . TYR C 3 13  ? 229.913 295.400 357.161 1.00 2.40  ? 13  TYR C CD1 1 
ATOM   3725 C CD2 . TYR C 3 13  ? 229.961 296.003 359.460 1.00 1.97  ? 13  TYR C CD2 1 
ATOM   3726 C CE1 . TYR C 3 13  ? 229.749 294.082 357.503 1.00 0.26  ? 13  TYR C CE1 1 
ATOM   3727 C CE2 . TYR C 3 13  ? 229.799 294.679 359.812 1.00 0.01  ? 13  TYR C CE2 1 
ATOM   3728 C CZ  . TYR C 3 13  ? 229.696 293.724 358.826 1.00 2.37  ? 13  TYR C CZ  1 
ATOM   3729 O OH  . TYR C 3 13  ? 229.535 292.402 359.155 1.00 7.27  ? 13  TYR C OH  1 
ATOM   3730 N N   . LEU C 3 14  ? 227.634 297.061 355.377 1.00 9.75  ? 14  LEU C N   1 
ATOM   3731 C CA  . LEU C 3 14  ? 226.341 296.399 355.288 1.00 2.76  ? 14  LEU C CA  1 
ATOM   3732 C C   . LEU C 3 14  ? 226.547 294.918 355.586 1.00 11.05 ? 14  LEU C C   1 
ATOM   3733 O O   . LEU C 3 14  ? 227.247 294.226 354.842 1.00 12.90 ? 14  LEU C O   1 
ATOM   3734 C CB  . LEU C 3 14  ? 225.726 296.598 353.902 1.00 0.81  ? 14  LEU C CB  1 
ATOM   3735 C CG  . LEU C 3 14  ? 224.432 295.839 353.592 1.00 8.85  ? 14  LEU C CG  1 
ATOM   3736 C CD1 . LEU C 3 14  ? 223.269 296.426 354.366 1.00 4.85  ? 14  LEU C CD1 1 
ATOM   3737 C CD2 . LEU C 3 14  ? 224.145 295.837 352.105 1.00 3.94  ? 14  LEU C CD2 1 
ATOM   3738 N N   . THR C 3 15  ? 225.923 294.430 356.659 1.00 5.77  ? 15  THR C N   1 
ATOM   3739 C CA  . THR C 3 15  ? 226.135 293.050 357.080 1.00 7.87  ? 15  THR C CA  1 
ATOM   3740 C C   . THR C 3 15  ? 225.628 292.037 356.064 1.00 6.78  ? 15  THR C C   1 
ATOM   3741 O O   . THR C 3 15  ? 225.969 290.857 356.176 1.00 12.29 ? 15  THR C O   1 
ATOM   3742 C CB  . THR C 3 15  ? 225.463 292.790 358.428 1.00 4.34  ? 15  THR C CB  1 
ATOM   3743 O OG1 . THR C 3 15  ? 224.052 293.003 358.315 1.00 14.30 ? 15  THR C OG1 1 
ATOM   3744 C CG2 . THR C 3 15  ? 226.032 293.705 359.492 1.00 0.01  ? 15  THR C CG2 1 
ATOM   3745 N N   . ALA C 3 16  ? 224.830 292.459 355.087 1.00 15.14 ? 16  ALA C N   1 
ATOM   3746 C CA  . ALA C 3 16  ? 224.365 291.583 354.024 1.00 6.66  ? 16  ALA C CA  1 
ATOM   3747 C C   . ALA C 3 16  ? 225.151 291.753 352.728 1.00 13.03 ? 16  ALA C C   1 
ATOM   3748 O O   . ALA C 3 16  ? 224.757 291.188 351.705 1.00 13.04 ? 16  ALA C O   1 
ATOM   3749 C CB  . ALA C 3 16  ? 222.877 291.818 353.763 1.00 8.19  ? 16  ALA C CB  1 
ATOM   3750 N N   . ASP C 3 17  ? 226.248 292.506 352.743 1.00 14.76 ? 17  ASP C N   1 
ATOM   3751 C CA  . ASP C 3 17  ? 227.020 292.703 351.524 1.00 13.01 ? 17  ASP C CA  1 
ATOM   3752 C C   . ASP C 3 17  ? 227.748 291.418 351.136 1.00 13.68 ? 17  ASP C C   1 
ATOM   3753 O O   . ASP C 3 17  ? 227.871 290.479 351.924 1.00 28.07 ? 17  ASP C O   1 
ATOM   3754 C CB  . ASP C 3 17  ? 228.018 293.857 351.689 1.00 11.90 ? 17  ASP C CB  1 
ATOM   3755 C CG  . ASP C 3 17  ? 229.123 293.562 352.702 1.00 17.20 ? 17  ASP C CG  1 
ATOM   3756 O OD1 . ASP C 3 17  ? 229.238 292.416 353.179 1.00 24.26 ? 17  ASP C OD1 1 
ATOM   3757 O OD2 . ASP C 3 17  ? 229.881 294.497 353.029 1.00 13.51 ? 17  ASP C OD2 1 
ATOM   3758 N N   . ASN C 3 18  ? 228.227 291.382 349.892 1.00 19.36 ? 18  ASN C N   1 
ATOM   3759 C CA  . ASN C 3 18  ? 228.982 290.246 349.357 1.00 14.26 ? 18  ASN C CA  1 
ATOM   3760 C C   . ASN C 3 18  ? 230.209 290.807 348.637 1.00 12.80 ? 18  ASN C C   1 
ATOM   3761 O O   . ASN C 3 18  ? 230.179 291.068 347.435 1.00 19.39 ? 18  ASN C O   1 
ATOM   3762 C CB  . ASN C 3 18  ? 228.108 289.392 348.431 1.00 12.80 ? 18  ASN C CB  1 
ATOM   3763 C CG  . ASN C 3 18  ? 228.683 288.011 348.195 1.00 15.56 ? 18  ASN C CG  1 
ATOM   3764 O OD1 . ASN C 3 18  ? 229.624 287.597 348.869 1.00 26.17 ? 18  ASN C OD1 1 
ATOM   3765 N ND2 . ASN C 3 18  ? 228.116 287.287 347.243 1.00 20.32 ? 18  ASN C ND2 1 
ATOM   3766 N N   . TYR C 3 19  ? 231.297 290.970 349.381 1.00 12.87 ? 19  TYR C N   1 
ATOM   3767 C CA  . TYR C 3 19  ? 232.533 291.546 348.878 1.00 9.33  ? 19  TYR C CA  1 
ATOM   3768 C C   . TYR C 3 19  ? 233.702 290.615 349.167 1.00 11.51 ? 19  TYR C C   1 
ATOM   3769 O O   . TYR C 3 19  ? 233.637 289.757 350.050 1.00 27.76 ? 19  TYR C O   1 
ATOM   3770 C CB  . TYR C 3 19  ? 232.806 292.916 349.513 1.00 12.20 ? 19  TYR C CB  1 
ATOM   3771 C CG  . TYR C 3 19  ? 231.865 294.015 349.080 1.00 9.95  ? 19  TYR C CG  1 
ATOM   3772 C CD1 . TYR C 3 19  ? 231.491 294.161 347.752 1.00 4.39  ? 19  TYR C CD1 1 
ATOM   3773 C CD2 . TYR C 3 19  ? 231.351 294.906 350.005 1.00 11.05 ? 19  TYR C CD2 1 
ATOM   3774 C CE1 . TYR C 3 19  ? 230.632 295.158 347.366 1.00 6.04  ? 19  TYR C CE1 1 
ATOM   3775 C CE2 . TYR C 3 19  ? 230.496 295.905 349.627 1.00 3.29  ? 19  TYR C CE2 1 
ATOM   3776 C CZ  . TYR C 3 19  ? 230.139 296.030 348.309 1.00 8.88  ? 19  TYR C CZ  1 
ATOM   3777 O OH  . TYR C 3 19  ? 229.282 297.032 347.932 1.00 18.52 ? 19  TYR C OH  1 
ATOM   3778 N N   . GLN C 3 20  ? 234.777 290.795 348.408 1.00 14.61 ? 20  GLN C N   1 
ATOM   3779 C CA  . GLN C 3 20  ? 236.015 290.078 348.663 1.00 11.83 ? 20  GLN C CA  1 
ATOM   3780 C C   . GLN C 3 20  ? 236.834 290.788 349.739 1.00 7.60  ? 20  GLN C C   1 
ATOM   3781 O O   . GLN C 3 20  ? 236.699 291.991 349.968 1.00 21.27 ? 20  GLN C O   1 
ATOM   3782 C CB  . GLN C 3 20  ? 236.835 289.953 347.381 1.00 11.77 ? 20  GLN C CB  1 
ATOM   3783 C CG  . GLN C 3 20  ? 236.139 289.178 346.281 1.00 17.93 ? 20  GLN C CG  1 
ATOM   3784 C CD  . GLN C 3 20  ? 236.885 289.240 344.965 1.00 27.31 ? 20  GLN C CD  1 
ATOM   3785 O OE1 . GLN C 3 20  ? 238.109 289.127 344.925 1.00 29.35 ? 20  GLN C OE1 1 
ATOM   3786 N NE2 . GLN C 3 20  ? 236.148 289.427 343.876 1.00 26.74 ? 20  GLN C NE2 1 
ATOM   3787 N N   . SER C 3 21  ? 237.683 290.020 350.410 1.00 9.22  ? 21  SER C N   1 
ATOM   3788 C CA  . SER C 3 21  ? 238.564 290.544 351.443 1.00 9.42  ? 21  SER C CA  1 
ATOM   3789 C C   . SER C 3 21  ? 239.875 289.777 351.391 1.00 9.07  ? 21  SER C C   1 
ATOM   3790 O O   . SER C 3 21  ? 239.930 288.675 350.835 1.00 17.52 ? 21  SER C O   1 
ATOM   3791 C CB  . SER C 3 21  ? 237.926 290.434 352.834 1.00 8.10  ? 21  SER C CB  1 
ATOM   3792 O OG  . SER C 3 21  ? 237.496 289.115 353.099 1.00 22.50 ? 21  SER C OG  1 
ATOM   3793 N N   . PRO C 3 22  ? 240.953 290.340 351.931 1.00 18.27 ? 22  PRO C N   1 
ATOM   3794 C CA  . PRO C 3 22  ? 242.234 289.625 351.921 1.00 13.99 ? 22  PRO C CA  1 
ATOM   3795 C C   . PRO C 3 22  ? 242.226 288.413 352.841 1.00 10.83 ? 22  PRO C C   1 
ATOM   3796 O O   . PRO C 3 22  ? 241.594 288.405 353.899 1.00 9.13  ? 22  PRO C O   1 
ATOM   3797 C CB  . PRO C 3 22  ? 243.233 290.685 352.401 1.00 13.29 ? 22  PRO C CB  1 
ATOM   3798 C CG  . PRO C 3 22  ? 242.418 291.647 353.182 1.00 7.47  ? 22  PRO C CG  1 
ATOM   3799 C CD  . PRO C 3 22  ? 241.075 291.681 352.526 1.00 8.43  ? 22  PRO C CD  1 
ATOM   3800 N N   . CYS C 3 23  ? 242.962 287.384 352.430 1.00 17.15 ? 23  CYS C N   1 
ATOM   3801 C CA  . CYS C 3 23  ? 243.068 286.162 353.216 1.00 12.86 ? 23  CYS C CA  1 
ATOM   3802 C C   . CYS C 3 23  ? 244.131 286.326 354.295 1.00 12.53 ? 23  CYS C C   1 
ATOM   3803 O O   . CYS C 3 23  ? 245.271 286.696 354.006 1.00 17.17 ? 23  CYS C O   1 
ATOM   3804 C CB  . CYS C 3 23  ? 243.406 284.976 352.313 1.00 14.40 ? 23  CYS C CB  1 
ATOM   3805 S SG  . CYS C 3 23  ? 243.394 283.372 353.147 1.00 35.11 ? 23  CYS C SG  1 
ATOM   3806 N N   . ALA C 3 24  ? 243.755 286.040 355.541 1.00 11.36 ? 24  ALA C N   1 
ATOM   3807 C CA  . ALA C 3 24  ? 244.666 286.187 356.667 1.00 9.85  ? 24  ALA C CA  1 
ATOM   3808 C C   . ALA C 3 24  ? 245.590 284.990 356.856 1.00 16.94 ? 24  ALA C C   1 
ATOM   3809 O O   . ALA C 3 24  ? 246.548 285.091 357.627 1.00 24.89 ? 24  ALA C O   1 
ATOM   3810 C CB  . ALA C 3 24  ? 243.871 286.424 357.952 1.00 8.06  ? 24  ALA C CB  1 
ATOM   3811 N N   . ILE C 3 25  ? 245.334 283.870 356.187 1.00 15.60 ? 25  ILE C N   1 
ATOM   3812 C CA  . ILE C 3 25  ? 246.200 282.697 356.280 1.00 15.60 ? 25  ILE C CA  1 
ATOM   3813 C C   . ILE C 3 25  ? 246.480 282.185 354.872 1.00 20.17 ? 25  ILE C C   1 
ATOM   3814 O O   . ILE C 3 25  ? 245.930 281.151 354.471 1.00 22.38 ? 25  ILE C O   1 
ATOM   3815 C CB  . ILE C 3 25  ? 245.571 281.597 357.150 1.00 18.32 ? 25  ILE C CB  1 
ATOM   3816 C CG1 . ILE C 3 25  ? 245.145 282.161 358.507 1.00 19.07 ? 25  ILE C CG1 1 
ATOM   3817 C CG2 . ILE C 3 25  ? 246.560 280.454 357.349 1.00 16.30 ? 25  ILE C CG2 1 
ATOM   3818 C CD1 . ILE C 3 25  ? 244.371 281.185 359.364 1.00 13.70 ? 25  ILE C CD1 1 
ATOM   3819 N N   . PRO C 3 26  ? 247.313 282.866 354.090 1.00 19.82 ? 26  PRO C N   1 
ATOM   3820 C CA  . PRO C 3 26  ? 247.542 282.434 352.707 1.00 13.02 ? 26  PRO C CA  1 
ATOM   3821 C C   . PRO C 3 26  ? 248.265 281.099 352.623 1.00 14.93 ? 26  PRO C C   1 
ATOM   3822 O O   . PRO C 3 26  ? 249.049 280.729 353.499 1.00 19.02 ? 26  PRO C O   1 
ATOM   3823 C CB  . PRO C 3 26  ? 248.392 283.566 352.119 1.00 12.82 ? 26  PRO C CB  1 
ATOM   3824 C CG  . PRO C 3 26  ? 249.024 284.217 353.288 1.00 7.96  ? 26  PRO C CG  1 
ATOM   3825 C CD  . PRO C 3 26  ? 248.056 284.094 354.416 1.00 9.73  ? 26  PRO C CD  1 
ATOM   3826 N N   . GLU C 3 27  ? 247.987 280.377 351.538 1.00 14.75 ? 27  GLU C N   1 
ATOM   3827 C CA  . GLU C 3 27  ? 248.614 279.096 351.220 1.00 17.03 ? 27  GLU C CA  1 
ATOM   3828 C C   . GLU C 3 27  ? 248.243 277.992 352.200 1.00 15.18 ? 27  GLU C C   1 
ATOM   3829 O O   . GLU C 3 27  ? 248.938 276.977 352.277 1.00 21.35 ? 27  GLU C O   1 
ATOM   3830 C CB  . GLU C 3 27  ? 250.141 279.226 351.150 1.00 12.07 ? 27  GLU C CB  1 
ATOM   3831 C CG  . GLU C 3 27  ? 250.624 280.253 350.152 1.00 18.13 ? 27  GLU C CG  1 
ATOM   3832 C CD  . GLU C 3 27  ? 250.131 279.978 348.748 1.00 23.49 ? 27  GLU C CD  1 
ATOM   3833 O OE1 . GLU C 3 27  ? 249.744 278.826 348.461 1.00 20.09 ? 27  GLU C OE1 1 
ATOM   3834 O OE2 . GLU C 3 27  ? 250.130 280.916 347.928 1.00 27.11 ? 27  GLU C OE2 1 
ATOM   3835 N N   . PHE C 3 28  ? 247.163 278.167 352.956 1.00 14.32 ? 28  PHE C N   1 
ATOM   3836 C CA  . PHE C 3 28  ? 246.692 277.111 353.839 1.00 14.18 ? 28  PHE C CA  1 
ATOM   3837 C C   . PHE C 3 28  ? 246.245 275.905 353.020 1.00 15.08 ? 28  PHE C C   1 
ATOM   3838 O O   . PHE C 3 28  ? 245.549 276.042 352.012 1.00 20.16 ? 28  PHE C O   1 
ATOM   3839 C CB  . PHE C 3 28  ? 245.541 277.634 354.697 1.00 8.93  ? 28  PHE C CB  1 
ATOM   3840 C CG  . PHE C 3 28  ? 245.145 276.724 355.819 1.00 13.59 ? 28  PHE C CG  1 
ATOM   3841 C CD1 . PHE C 3 28  ? 245.809 276.767 357.033 1.00 13.84 ? 28  PHE C CD1 1 
ATOM   3842 C CD2 . PHE C 3 28  ? 244.093 275.839 355.671 1.00 15.07 ? 28  PHE C CD2 1 
ATOM   3843 C CE1 . PHE C 3 28  ? 245.438 275.939 358.069 1.00 9.54  ? 28  PHE C CE1 1 
ATOM   3844 C CE2 . PHE C 3 28  ? 243.718 275.011 356.705 1.00 10.47 ? 28  PHE C CE2 1 
ATOM   3845 C CZ  . PHE C 3 28  ? 244.388 275.061 357.906 1.00 10.36 ? 28  PHE C CZ  1 
ATOM   3846 N N   . ASP C 3 29  ? 246.661 274.718 353.452 1.00 17.45 ? 29  ASP C N   1 
ATOM   3847 C CA  . ASP C 3 29  ? 246.313 273.472 352.770 1.00 16.86 ? 29  ASP C CA  1 
ATOM   3848 C C   . ASP C 3 29  ? 245.066 272.902 353.438 1.00 15.62 ? 29  ASP C C   1 
ATOM   3849 O O   . ASP C 3 29  ? 245.144 272.273 354.495 1.00 21.92 ? 29  ASP C O   1 
ATOM   3850 C CB  . ASP C 3 29  ? 247.484 272.497 352.812 1.00 14.46 ? 29  ASP C CB  1 
ATOM   3851 C CG  . ASP C 3 29  ? 247.202 271.211 352.065 1.00 24.86 ? 29  ASP C CG  1 
ATOM   3852 O OD1 . ASP C 3 29  ? 246.678 271.277 350.935 1.00 25.35 ? 29  ASP C OD1 1 
ATOM   3853 O OD2 . ASP C 3 29  ? 247.520 270.131 352.601 1.00 32.06 ? 29  ASP C OD2 1 
ATOM   3854 N N   . VAL C 3 30  ? 243.910 273.118 352.810 1.00 14.58 ? 30  VAL C N   1 
ATOM   3855 C CA  . VAL C 3 30  ? 242.632 272.820 353.444 1.00 17.95 ? 30  VAL C CA  1 
ATOM   3856 C C   . VAL C 3 30  ? 242.366 271.321 353.423 1.00 17.02 ? 30  VAL C C   1 
ATOM   3857 O O   . VAL C 3 30  ? 242.631 270.635 352.426 1.00 17.28 ? 30  VAL C O   1 
ATOM   3858 C CB  . VAL C 3 30  ? 241.501 273.596 352.746 1.00 11.50 ? 30  VAL C CB  1 
ATOM   3859 C CG1 . VAL C 3 30  ? 240.146 273.127 353.236 1.00 12.14 ? 30  VAL C CG1 1 
ATOM   3860 C CG2 . VAL C 3 30  ? 241.660 275.082 352.987 1.00 11.80 ? 30  VAL C CG2 1 
ATOM   3861 N N   . THR C 3 31  ? 241.838 270.807 354.531 1.00 16.04 ? 31  THR C N   1 
ATOM   3862 C CA  . THR C 3 31  ? 241.444 269.407 354.600 1.00 13.20 ? 31  THR C CA  1 
ATOM   3863 C C   . THR C 3 31  ? 240.313 269.145 353.608 1.00 11.93 ? 31  THR C C   1 
ATOM   3864 O O   . THR C 3 31  ? 239.329 269.895 353.590 1.00 22.87 ? 31  THR C O   1 
ATOM   3865 C CB  . THR C 3 31  ? 240.992 269.043 356.015 1.00 14.08 ? 31  THR C CB  1 
ATOM   3866 O OG1 . THR C 3 31  ? 242.053 269.294 356.942 1.00 20.90 ? 31  THR C OG1 1 
ATOM   3867 C CG2 . THR C 3 31  ? 240.597 267.576 356.103 1.00 15.71 ? 31  THR C CG2 1 
ATOM   3868 N N   . PRO C 3 32  ? 240.407 268.112 352.776 1.00 16.75 ? 32  PRO C N   1 
ATOM   3869 C CA  . PRO C 3 32  ? 239.338 267.841 351.810 1.00 17.68 ? 32  PRO C CA  1 
ATOM   3870 C C   . PRO C 3 32  ? 238.088 267.337 352.507 1.00 14.57 ? 32  PRO C C   1 
ATOM   3871 O O   . PRO C 3 32  ? 238.167 266.751 353.597 1.00 22.06 ? 32  PRO C O   1 
ATOM   3872 C CB  . PRO C 3 32  ? 239.946 266.764 350.902 1.00 17.65 ? 32  PRO C CB  1 
ATOM   3873 C CG  . PRO C 3 32  ? 240.932 266.068 351.764 1.00 18.16 ? 32  PRO C CG  1 
ATOM   3874 C CD  . PRO C 3 32  ? 241.484 267.107 352.697 1.00 12.41 ? 32  PRO C CD  1 
ATOM   3875 N N   . PRO C 3 33  ? 236.913 267.550 351.919 1.00 17.25 ? 33  PRO C N   1 
ATOM   3876 C CA  . PRO C 3 33  ? 235.685 267.013 352.516 1.00 18.11 ? 33  PRO C CA  1 
ATOM   3877 C C   . PRO C 3 33  ? 235.558 265.513 352.302 1.00 19.69 ? 33  PRO C C   1 
ATOM   3878 O O   . PRO C 3 33  ? 236.120 264.947 351.362 1.00 24.77 ? 33  PRO C O   1 
ATOM   3879 C CB  . PRO C 3 33  ? 234.578 267.773 351.776 1.00 13.64 ? 33  PRO C CB  1 
ATOM   3880 C CG  . PRO C 3 33  ? 235.171 268.072 350.452 1.00 13.59 ? 33  PRO C CG  1 
ATOM   3881 C CD  . PRO C 3 33  ? 236.637 268.304 350.684 1.00 14.35 ? 33  PRO C CD  1 
ATOM   3882 N N   . ILE C 3 34  ? 234.813 264.871 353.191 1.00 22.49 ? 34  ILE C N   1 
ATOM   3883 C CA  . ILE C 3 34  ? 234.437 263.482 353.023 1.00 18.52 ? 34  ILE C CA  1 
ATOM   3884 C C   . ILE C 3 34  ? 232.936 263.410 352.770 1.00 14.95 ? 34  ILE C C   1 
ATOM   3885 O O   . ILE C 3 34  ? 232.202 264.377 352.956 1.00 18.49 ? 34  ILE C O   1 
ATOM   3886 C CB  . ILE C 3 34  ? 234.845 262.616 354.239 1.00 18.90 ? 34  ILE C CB  1 
ATOM   3887 C CG1 . ILE C 3 34  ? 234.270 263.199 355.531 1.00 21.44 ? 34  ILE C CG1 1 
ATOM   3888 C CG2 . ILE C 3 34  ? 236.352 262.499 354.315 1.00 19.71 ? 34  ILE C CG2 1 
ATOM   3889 C CD1 . ILE C 3 34  ? 234.515 262.351 356.751 1.00 15.03 ? 34  ILE C CD1 1 
ATOM   3890 N N   . ASP C 3 35  ? 232.471 262.243 352.335 1.00 23.28 ? 35  ASP C N   1 
ATOM   3891 C CA  . ASP C 3 35  ? 231.060 262.020 352.030 1.00 22.51 ? 35  ASP C CA  1 
ATOM   3892 C C   . ASP C 3 35  ? 230.341 261.658 353.324 1.00 20.88 ? 35  ASP C C   1 
ATOM   3893 O O   . ASP C 3 35  ? 230.188 260.488 353.670 1.00 28.78 ? 35  ASP C O   1 
ATOM   3894 C CB  . ASP C 3 35  ? 230.912 260.927 350.980 1.00 18.38 ? 35  ASP C CB  1 
ATOM   3895 C CG  . ASP C 3 35  ? 229.500 260.822 350.435 1.00 31.50 ? 35  ASP C CG  1 
ATOM   3896 O OD1 . ASP C 3 35  ? 228.638 261.638 350.820 1.00 33.19 ? 35  ASP C OD1 1 
ATOM   3897 O OD2 . ASP C 3 35  ? 229.252 259.916 349.615 1.00 34.74 ? 35  ASP C OD2 1 
ATOM   3898 N N   . ILE C 3 36  ? 229.908 262.677 354.057 1.00 16.28 ? 36  ILE C N   1 
ATOM   3899 C CA  . ILE C 3 36  ? 229.157 262.474 355.292 1.00 14.92 ? 36  ILE C CA  1 
ATOM   3900 C C   . ILE C 3 36  ? 227.693 262.240 354.931 1.00 10.50 ? 36  ILE C C   1 
ATOM   3901 O O   . ILE C 3 36  ? 227.170 262.909 354.030 1.00 17.74 ? 36  ILE C O   1 
ATOM   3902 C CB  . ILE C 3 36  ? 229.310 263.667 356.248 1.00 9.85  ? 36  ILE C CB  1 
ATOM   3903 C CG1 . ILE C 3 36  ? 230.787 263.922 356.551 1.00 13.19 ? 36  ILE C CG1 1 
ATOM   3904 C CG2 . ILE C 3 36  ? 228.526 263.427 357.530 1.00 9.32  ? 36  ILE C CG2 1 
ATOM   3905 C CD1 . ILE C 3 36  ? 231.034 265.085 357.490 1.00 8.95  ? 36  ILE C CD1 1 
ATOM   3906 N N   . PRO C 3 37  ? 226.999 261.308 355.579 1.00 18.13 ? 37  PRO C N   1 
ATOM   3907 C CA  . PRO C 3 37  ? 225.562 261.163 355.327 1.00 14.09 ? 37  PRO C CA  1 
ATOM   3908 C C   . PRO C 3 37  ? 224.767 262.339 355.876 1.00 14.29 ? 37  PRO C C   1 
ATOM   3909 O O   . PRO C 3 37  ? 225.166 262.994 356.841 1.00 16.66 ? 37  PRO C O   1 
ATOM   3910 C CB  . PRO C 3 37  ? 225.198 259.863 356.056 1.00 13.25 ? 37  PRO C CB  1 
ATOM   3911 C CG  . PRO C 3 37  ? 226.492 259.181 356.327 1.00 9.52  ? 37  PRO C CG  1 
ATOM   3912 C CD  . PRO C 3 37  ? 227.502 260.256 356.478 1.00 11.80 ? 37  PRO C CD  1 
ATOM   3913 N N   . GLY C 3 38  ? 223.626 262.599 355.242 1.00 16.83 ? 38  GLY C N   1 
ATOM   3914 C CA  . GLY C 3 38  ? 222.691 263.582 355.752 1.00 7.67  ? 38  GLY C CA  1 
ATOM   3915 C C   . GLY C 3 38  ? 222.976 265.024 355.398 1.00 14.44 ? 38  GLY C C   1 
ATOM   3916 O O   . GLY C 3 38  ? 222.710 265.912 356.212 1.00 12.61 ? 38  GLY C O   1 
ATOM   3917 N N   . GLU C 3 39  ? 223.504 265.291 354.207 1.00 14.49 ? 39  GLU C N   1 
ATOM   3918 C CA  . GLU C 3 39  ? 223.761 266.667 353.804 1.00 9.59  ? 39  GLU C CA  1 
ATOM   3919 C C   . GLU C 3 39  ? 222.460 267.392 353.472 1.00 20.84 ? 39  GLU C C   1 
ATOM   3920 O O   . GLU C 3 39  ? 221.518 266.802 352.937 1.00 15.16 ? 39  GLU C O   1 
ATOM   3921 C CB  . GLU C 3 39  ? 224.697 266.708 352.599 1.00 9.94  ? 39  GLU C CB  1 
ATOM   3922 C CG  . GLU C 3 39  ? 225.195 268.106 352.290 1.00 19.91 ? 39  GLU C CG  1 
ATOM   3923 C CD  . GLU C 3 39  ? 226.283 268.134 351.247 1.00 16.96 ? 39  GLU C CD  1 
ATOM   3924 O OE1 . GLU C 3 39  ? 226.563 267.083 350.643 1.00 24.97 ? 39  GLU C OE1 1 
ATOM   3925 O OE2 . GLU C 3 39  ? 226.863 269.214 351.032 1.00 20.21 ? 39  GLU C OE2 1 
ATOM   3926 N N   . VAL C 3 40  ? 222.421 268.685 353.786 1.00 22.81 ? 40  VAL C N   1 
ATOM   3927 C CA  . VAL C 3 40  ? 221.263 269.540 353.552 1.00 15.58 ? 40  VAL C CA  1 
ATOM   3928 C C   . VAL C 3 40  ? 221.696 270.707 352.676 1.00 17.11 ? 40  VAL C C   1 
ATOM   3929 O O   . VAL C 3 40  ? 222.725 271.337 352.940 1.00 16.36 ? 40  VAL C O   1 
ATOM   3930 C CB  . VAL C 3 40  ? 220.661 270.050 354.875 1.00 18.05 ? 40  VAL C CB  1 
ATOM   3931 C CG1 . VAL C 3 40  ? 219.508 270.996 354.610 1.00 13.43 ? 40  VAL C CG1 1 
ATOM   3932 C CG2 . VAL C 3 40  ? 220.212 268.887 355.738 1.00 15.23 ? 40  VAL C CG2 1 
ATOM   3933 N N   . ARG C 3 41  ? 220.907 270.995 351.637 1.00 22.81 ? 41  ARG C N   1 
ATOM   3934 C CA  . ARG C 3 41  ? 221.148 272.134 350.761 1.00 14.59 ? 41  ARG C CA  1 
ATOM   3935 C C   . ARG C 3 41  ? 220.174 273.283 350.969 1.00 16.61 ? 41  ARG C C   1 
ATOM   3936 O O   . ARG C 3 41  ? 220.515 274.422 350.641 1.00 22.68 ? 41  ARG C O   1 
ATOM   3937 C CB  . ARG C 3 41  ? 221.064 271.714 349.287 1.00 16.92 ? 41  ARG C CB  1 
ATOM   3938 C CG  . ARG C 3 41  ? 221.693 270.383 348.963 1.00 21.31 ? 41  ARG C CG  1 
ATOM   3939 C CD  . ARG C 3 41  ? 223.187 270.384 349.179 1.00 21.59 ? 41  ARG C CD  1 
ATOM   3940 N NE  . ARG C 3 41  ? 223.725 269.031 349.110 1.00 34.43 ? 41  ARG C NE  1 
ATOM   3941 C CZ  . ARG C 3 41  ? 223.910 268.355 347.985 1.00 33.29 ? 41  ARG C CZ  1 
ATOM   3942 N NH1 . ARG C 3 41  ? 223.609 268.876 346.807 1.00 34.38 ? 41  ARG C NH1 1 
ATOM   3943 N NH2 . ARG C 3 41  ? 224.405 267.122 348.042 1.00 26.28 ? 41  ARG C NH2 1 
ATOM   3944 N N   . ASN C 3 42  ? 218.979 273.017 351.486 1.00 14.46 ? 42  ASN C N   1 
ATOM   3945 C CA  . ASN C 3 42  ? 217.939 274.026 351.605 1.00 14.15 ? 42  ASN C CA  1 
ATOM   3946 C C   . ASN C 3 42  ? 217.211 273.830 352.923 1.00 14.85 ? 42  ASN C C   1 
ATOM   3947 O O   . ASN C 3 42  ? 216.892 272.701 353.297 1.00 22.89 ? 42  ASN C O   1 
ATOM   3948 C CB  . ASN C 3 42  ? 216.953 273.932 350.433 1.00 16.94 ? 42  ASN C CB  1 
ATOM   3949 C CG  . ASN C 3 42  ? 216.352 275.273 350.060 1.00 13.72 ? 42  ASN C CG  1 
ATOM   3950 O OD1 . ASN C 3 42  ? 215.411 275.741 350.691 1.00 13.28 ? 42  ASN C OD1 1 
ATOM   3951 N ND2 . ASN C 3 42  ? 216.890 275.890 349.020 1.00 8.51  ? 42  ASN C ND2 1 
ATOM   3952 N N   . MET C 3 43  ? 216.947 274.932 353.625 1.00 15.65 ? 43  MET C N   1 
ATOM   3953 C CA  . MET C 3 43  ? 216.229 274.838 354.890 1.00 13.07 ? 43  MET C CA  1 
ATOM   3954 C C   . MET C 3 43  ? 214.823 274.285 354.704 1.00 14.42 ? 43  MET C C   1 
ATOM   3955 O O   . MET C 3 43  ? 214.277 273.687 355.636 1.00 19.95 ? 43  MET C O   1 
ATOM   3956 C CB  . MET C 3 43  ? 216.164 276.208 355.564 1.00 8.69  ? 43  MET C CB  1 
ATOM   3957 C CG  . MET C 3 43  ? 217.515 276.879 355.743 1.00 12.79 ? 43  MET C CG  1 
ATOM   3958 S SD  . MET C 3 43  ? 218.709 275.892 356.663 1.00 16.42 ? 43  MET C SD  1 
ATOM   3959 C CE  . MET C 3 43  ? 217.983 275.892 358.294 1.00 9.68  ? 43  MET C CE  1 
ATOM   3960 N N   . MET C 3 44  ? 214.229 274.464 353.523 1.00 16.72 ? 44  MET C N   1 
ATOM   3961 C CA  . MET C 3 44  ? 212.922 273.880 353.256 1.00 14.46 ? 44  MET C CA  1 
ATOM   3962 C C   . MET C 3 44  ? 212.947 272.364 353.353 1.00 15.03 ? 44  MET C C   1 
ATOM   3963 O O   . MET C 3 44  ? 211.930 271.761 353.708 1.00 26.28 ? 44  MET C O   1 
ATOM   3964 C CB  . MET C 3 44  ? 212.424 274.306 351.874 1.00 14.23 ? 44  MET C CB  1 
ATOM   3965 C CG  . MET C 3 44  ? 211.971 275.756 351.784 1.00 10.44 ? 44  MET C CG  1 
ATOM   3966 S SD  . MET C 3 44  ? 210.571 276.145 352.848 1.00 32.08 ? 44  MET C SD  1 
ATOM   3967 C CE  . MET C 3 44  ? 211.387 276.771 354.309 1.00 13.64 ? 44  MET C CE  1 
ATOM   3968 N N   . GLU C 3 45  ? 214.088 271.737 353.067 1.00 15.58 ? 45  GLU C N   1 
ATOM   3969 C CA  . GLU C 3 45  ? 214.203 270.297 353.259 1.00 16.69 ? 45  GLU C CA  1 
ATOM   3970 C C   . GLU C 3 45  ? 213.923 269.907 354.703 1.00 13.79 ? 45  GLU C C   1 
ATOM   3971 O O   . GLU C 3 45  ? 213.402 268.816 354.955 1.00 20.35 ? 45  GLU C O   1 
ATOM   3972 C CB  . GLU C 3 45  ? 215.590 269.821 352.835 1.00 17.31 ? 45  GLU C CB  1 
ATOM   3973 C CG  . GLU C 3 45  ? 215.885 270.034 351.360 1.00 24.39 ? 45  GLU C CG  1 
ATOM   3974 C CD  . GLU C 3 45  ? 217.346 269.826 351.015 1.00 28.62 ? 45  GLU C CD  1 
ATOM   3975 O OE1 . GLU C 3 45  ? 218.118 269.418 351.904 1.00 24.09 ? 45  GLU C OE1 1 
ATOM   3976 O OE2 . GLU C 3 45  ? 217.724 270.075 349.852 1.00 34.16 ? 45  GLU C OE2 1 
ATOM   3977 N N   . LEU C 3 46  ? 214.258 270.775 355.661 1.00 14.09 ? 46  LEU C N   1 
ATOM   3978 C CA  . LEU C 3 46  ? 213.909 270.504 357.049 1.00 15.28 ? 46  LEU C CA  1 
ATOM   3979 C C   . LEU C 3 46  ? 212.437 270.761 357.320 1.00 16.26 ? 46  LEU C C   1 
ATOM   3980 O O   . LEU C 3 46  ? 211.839 270.083 358.161 1.00 22.90 ? 46  LEU C O   1 
ATOM   3981 C CB  . LEU C 3 46  ? 214.754 271.357 357.998 1.00 22.65 ? 46  LEU C CB  1 
ATOM   3982 C CG  . LEU C 3 46  ? 216.273 271.304 357.861 1.00 14.61 ? 46  LEU C CG  1 
ATOM   3983 C CD1 . LEU C 3 46  ? 216.913 271.776 359.151 1.00 19.39 ? 46  LEU C CD1 1 
ATOM   3984 C CD2 . LEU C 3 46  ? 216.758 269.918 357.489 1.00 20.20 ? 46  LEU C CD2 1 
ATOM   3985 N N   . ALA C 3 47  ? 211.840 271.731 356.627 1.00 21.43 ? 47  ALA C N   1 
ATOM   3986 C CA  . ALA C 3 47  ? 210.429 272.030 356.825 1.00 17.27 ? 47  ALA C CA  1 
ATOM   3987 C C   . ALA C 3 47  ? 209.530 270.967 356.211 1.00 14.78 ? 47  ALA C C   1 
ATOM   3988 O O   . ALA C 3 47  ? 208.345 270.906 356.547 1.00 19.62 ? 47  ALA C O   1 
ATOM   3989 C CB  . ALA C 3 47  ? 210.103 273.402 356.238 1.00 15.95 ? 47  ALA C CB  1 
ATOM   3990 N N   . GLU C 3 48  ? 210.068 270.133 355.327 1.00 16.97 ? 48  GLU C N   1 
ATOM   3991 C CA  . GLU C 3 48  ? 209.327 269.053 354.698 1.00 17.36 ? 48  GLU C CA  1 
ATOM   3992 C C   . GLU C 3 48  ? 209.343 267.774 355.521 1.00 19.68 ? 48  GLU C C   1 
ATOM   3993 O O   . GLU C 3 48  ? 208.832 266.751 355.061 1.00 22.31 ? 48  GLU C O   1 
ATOM   3994 C CB  . GLU C 3 48  ? 209.893 268.775 353.306 1.00 16.76 ? 48  GLU C CB  1 
ATOM   3995 C CG  . GLU C 3 48  ? 209.550 269.828 352.275 1.00 21.45 ? 48  GLU C CG  1 
ATOM   3996 C CD  . GLU C 3 48  ? 210.297 269.621 350.976 1.00 28.25 ? 48  GLU C CD  1 
ATOM   3997 O OE1 . GLU C 3 48  ? 211.373 268.987 351.005 1.00 37.24 ? 48  GLU C OE1 1 
ATOM   3998 O OE2 . GLU C 3 48  ? 209.812 270.084 349.926 1.00 25.11 ? 48  GLU C OE2 1 
ATOM   3999 N N   . ILE C 3 49  ? 209.921 267.808 356.716 1.00 17.26 ? 49  ILE C N   1 
ATOM   4000 C CA  . ILE C 3 49  ? 209.945 266.667 357.620 1.00 16.86 ? 49  ILE C CA  1 
ATOM   4001 C C   . ILE C 3 49  ? 208.786 266.801 358.594 1.00 15.70 ? 49  ILE C C   1 
ATOM   4002 O O   . ILE C 3 49  ? 208.581 267.867 359.185 1.00 22.00 ? 49  ILE C O   1 
ATOM   4003 C CB  . ILE C 3 49  ? 211.286 266.580 358.369 1.00 17.77 ? 49  ILE C CB  1 
ATOM   4004 C CG1 . ILE C 3 49  ? 212.422 266.288 357.385 1.00 20.88 ? 49  ILE C CG1 1 
ATOM   4005 C CG2 . ILE C 3 49  ? 211.216 265.520 359.456 1.00 8.56  ? 49  ILE C CG2 1 
ATOM   4006 C CD1 . ILE C 3 49  ? 213.798 266.539 357.953 1.00 14.24 ? 49  ILE C CD1 1 
ATOM   4007 N N   . ASP C 3 50  ? 208.020 265.727 358.751 1.00 14.66 ? 50  ASP C N   1 
ATOM   4008 C CA  . ASP C 3 50  ? 206.923 265.717 359.707 1.00 9.90  ? 50  ASP C CA  1 
ATOM   4009 C C   . ASP C 3 50  ? 207.458 265.779 361.130 1.00 13.18 ? 50  ASP C C   1 
ATOM   4010 O O   . ASP C 3 50  ? 208.368 265.031 361.495 1.00 22.13 ? 50  ASP C O   1 
ATOM   4011 C CB  . ASP C 3 50  ? 206.075 264.460 359.520 1.00 16.46 ? 50  ASP C CB  1 
ATOM   4012 C CG  . ASP C 3 50  ? 205.257 264.492 358.249 1.00 27.78 ? 50  ASP C CG  1 
ATOM   4013 O OD1 . ASP C 3 50  ? 204.634 265.535 357.971 1.00 27.24 ? 50  ASP C OD1 1 
ATOM   4014 O OD2 . ASP C 3 50  ? 205.238 263.477 357.523 1.00 29.66 ? 50  ASP C OD2 1 
ATOM   4015 N N   . THR C 3 51  ? 206.887 266.668 361.935 1.00 13.98 ? 51  THR C N   1 
ATOM   4016 C CA  . THR C 3 51  ? 207.196 266.748 363.352 1.00 11.95 ? 51  THR C CA  1 
ATOM   4017 C C   . THR C 3 51  ? 205.896 266.837 364.135 1.00 7.55  ? 51  THR C C   1 
ATOM   4018 O O   . THR C 3 51  ? 204.892 267.363 363.655 1.00 14.42 ? 51  THR C O   1 
ATOM   4019 C CB  . THR C 3 51  ? 208.101 267.948 363.681 1.00 11.88 ? 51  THR C CB  1 
ATOM   4020 O OG1 . THR C 3 51  ? 207.534 269.149 363.147 1.00 22.58 ? 51  THR C OG1 1 
ATOM   4021 C CG2 . THR C 3 51  ? 209.491 267.739 363.104 1.00 7.75  ? 51  THR C CG2 1 
ATOM   4022 N N   . MET C 3 52  ? 205.936 266.319 365.356 1.00 11.40 ? 52  MET C N   1 
ATOM   4023 C CA  . MET C 3 52  ? 204.743 266.198 366.177 1.00 11.85 ? 52  MET C CA  1 
ATOM   4024 C C   . MET C 3 52  ? 204.260 267.570 366.632 1.00 11.08 ? 52  MET C C   1 
ATOM   4025 O O   . MET C 3 52  ? 205.059 268.441 366.982 1.00 17.56 ? 52  MET C O   1 
ATOM   4026 C CB  . MET C 3 52  ? 205.037 265.303 367.379 1.00 12.22 ? 52  MET C CB  1 
ATOM   4027 C CG  . MET C 3 52  ? 203.811 264.773 368.089 1.00 23.29 ? 52  MET C CG  1 
ATOM   4028 S SD  . MET C 3 52  ? 204.227 263.518 369.310 1.00 25.57 ? 52  MET C SD  1 
ATOM   4029 C CE  . MET C 3 52  ? 204.483 262.113 368.248 1.00 17.04 ? 52  MET C CE  1 
ATOM   4030 N N   . ILE C 3 53  ? 202.944 267.753 366.627 1.00 15.09 ? 53  ILE C N   1 
ATOM   4031 C CA  . ILE C 3 53  ? 202.324 269.032 366.959 1.00 14.46 ? 53  ILE C CA  1 
ATOM   4032 C C   . ILE C 3 53  ? 201.959 269.015 368.441 1.00 17.35 ? 53  ILE C C   1 
ATOM   4033 O O   . ILE C 3 53  ? 201.234 268.108 368.874 1.00 16.23 ? 53  ILE C O   1 
ATOM   4034 C CB  . ILE C 3 53  ? 201.079 269.291 366.104 1.00 14.99 ? 53  ILE C CB  1 
ATOM   4035 C CG1 . ILE C 3 53  ? 201.424 269.244 364.615 1.00 16.39 ? 53  ILE C CG1 1 
ATOM   4036 C CG2 . ILE C 3 53  ? 200.456 270.632 366.471 1.00 11.22 ? 53  ILE C CG2 1 
ATOM   4037 C CD1 . ILE C 3 53  ? 200.218 269.245 363.724 1.00 12.27 ? 53  ILE C CD1 1 
ATOM   4038 N N   . PRO C 3 54  ? 202.416 269.979 369.240 1.00 14.91 ? 54  PRO C N   1 
ATOM   4039 C CA  . PRO C 3 54  ? 201.914 270.076 370.616 1.00 17.59 ? 54  PRO C CA  1 
ATOM   4040 C C   . PRO C 3 54  ? 200.494 270.614 370.658 1.00 18.62 ? 54  PRO C C   1 
ATOM   4041 O O   . PRO C 3 54  ? 200.272 271.796 370.931 1.00 27.56 ? 54  PRO C O   1 
ATOM   4042 C CB  . PRO C 3 54  ? 202.909 271.028 371.287 1.00 16.83 ? 54  PRO C CB  1 
ATOM   4043 C CG  . PRO C 3 54  ? 203.432 271.857 370.178 1.00 18.19 ? 54  PRO C CG  1 
ATOM   4044 C CD  . PRO C 3 54  ? 203.467 270.975 368.967 1.00 10.61 ? 54  PRO C CD  1 
ATOM   4045 N N   . LEU C 3 55  ? 199.521 269.745 370.385 1.00 19.21 ? 55  LEU C N   1 
ATOM   4046 C CA  . LEU C 3 55  ? 198.132 270.163 370.250 1.00 20.63 ? 55  LEU C CA  1 
ATOM   4047 C C   . LEU C 3 55  ? 197.469 270.503 371.577 1.00 20.44 ? 55  LEU C C   1 
ATOM   4048 O O   . LEU C 3 55  ? 196.662 271.436 371.626 1.00 24.20 ? 55  LEU C O   1 
ATOM   4049 C CB  . LEU C 3 55  ? 197.328 269.063 369.558 1.00 18.07 ? 55  LEU C CB  1 
ATOM   4050 C CG  . LEU C 3 55  ? 197.711 268.762 368.110 1.00 19.24 ? 55  LEU C CG  1 
ATOM   4051 C CD1 . LEU C 3 55  ? 197.296 267.356 367.725 1.00 19.59 ? 55  LEU C CD1 1 
ATOM   4052 C CD2 . LEU C 3 55  ? 197.076 269.771 367.178 1.00 21.77 ? 55  LEU C CD2 1 
ATOM   4053 N N   . ASN C 3 56  ? 197.778 269.774 372.642 1.00 24.28 ? 56  ASN C N   1 
ATOM   4054 C CA  . ASN C 3 56  ? 197.059 269.872 373.907 1.00 23.19 ? 56  ASN C CA  1 
ATOM   4055 C C   . ASN C 3 56  ? 197.817 270.779 374.874 1.00 21.37 ? 56  ASN C C   1 
ATOM   4056 O O   . ASN C 3 56  ? 198.350 270.338 375.892 1.00 25.09 ? 56  ASN C O   1 
ATOM   4057 C CB  . ASN C 3 56  ? 196.851 268.470 374.483 1.00 23.71 ? 56  ASN C CB  1 
ATOM   4058 C CG  . ASN C 3 56  ? 195.465 268.269 375.044 1.00 24.42 ? 56  ASN C CG  1 
ATOM   4059 O OD1 . ASN C 3 56  ? 194.871 269.186 375.603 1.00 27.58 ? 56  ASN C OD1 1 
ATOM   4060 N ND2 . ASN C 3 56  ? 194.940 267.063 374.896 1.00 24.23 ? 56  ASN C ND2 1 
ATOM   4061 N N   . LEU C 3 57  ? 197.853 272.072 374.553 1.00 22.78 ? 57  LEU C N   1 
ATOM   4062 C CA  . LEU C 3 57  ? 198.574 273.055 375.367 1.00 23.93 ? 57  LEU C CA  1 
ATOM   4063 C C   . LEU C 3 57  ? 197.678 273.622 376.471 1.00 20.98 ? 57  LEU C C   1 
ATOM   4064 O O   . LEU C 3 57  ? 197.386 274.814 376.527 1.00 29.29 ? 57  LEU C O   1 
ATOM   4065 C CB  . LEU C 3 57  ? 199.117 274.172 374.485 1.00 18.76 ? 57  LEU C CB  1 
ATOM   4066 C CG  . LEU C 3 57  ? 200.277 273.831 373.552 1.00 22.67 ? 57  LEU C CG  1 
ATOM   4067 C CD1 . LEU C 3 57  ? 200.680 275.055 372.755 1.00 23.15 ? 57  LEU C CD1 1 
ATOM   4068 C CD2 . LEU C 3 57  ? 201.466 273.284 374.325 1.00 22.60 ? 57  LEU C CD2 1 
ATOM   4069 N N   . THR C 3 58  ? 197.246 272.743 377.366 1.00 29.86 ? 58  THR C N   1 
ATOM   4070 C CA  . THR C 3 58  ? 196.477 273.166 378.526 1.00 31.27 ? 58  THR C CA  1 
ATOM   4071 C C   . THR C 3 58  ? 197.415 273.467 379.693 1.00 32.51 ? 58  THR C C   1 
ATOM   4072 O O   . THR C 3 58  ? 198.627 273.267 379.619 1.00 30.72 ? 58  THR C O   1 
ATOM   4073 C CB  . THR C 3 58  ? 195.452 272.102 378.923 1.00 27.40 ? 58  THR C CB  1 
ATOM   4074 O OG1 . THR C 3 58  ? 196.122 270.879 379.242 1.00 33.59 ? 58  THR C OG1 1 
ATOM   4075 C CG2 . THR C 3 58  ? 194.468 271.856 377.788 1.00 30.50 ? 58  THR C CG2 1 
ATOM   4076 N N   . ASN C 3 59  ? 196.832 273.957 380.788 1.00 34.56 ? 59  ASN C N   1 
ATOM   4077 C CA  . ASN C 3 59  ? 197.639 274.351 381.938 1.00 32.84 ? 59  ASN C CA  1 
ATOM   4078 C C   . ASN C 3 59  ? 198.434 273.175 382.490 1.00 37.63 ? 59  ASN C C   1 
ATOM   4079 O O   . ASN C 3 59  ? 199.607 273.322 382.849 1.00 37.35 ? 59  ASN C O   1 
ATOM   4080 C CB  . ASN C 3 59  ? 196.744 274.944 383.026 1.00 34.52 ? 59  ASN C CB  1 
ATOM   4081 C CG  . ASN C 3 59  ? 197.535 275.618 384.130 1.00 38.83 ? 59  ASN C CG  1 
ATOM   4082 O OD1 . ASN C 3 59  ? 198.528 276.298 383.872 1.00 40.65 ? 59  ASN C OD1 1 
ATOM   4083 N ND2 . ASN C 3 59  ? 197.101 275.430 385.370 1.00 39.30 ? 59  ASN C ND2 1 
ATOM   4084 N N   . GLN C 3 60  ? 197.812 271.999 382.571 1.00 37.13 ? 60  GLN C N   1 
ATOM   4085 C CA  . GLN C 3 60  ? 198.452 270.824 383.144 1.00 33.78 ? 60  GLN C CA  1 
ATOM   4086 C C   . GLN C 3 60  ? 199.245 270.008 382.132 1.00 33.17 ? 60  GLN C C   1 
ATOM   4087 O O   . GLN C 3 60  ? 199.974 269.098 382.537 1.00 39.48 ? 60  GLN C O   1 
ATOM   4088 C CB  . GLN C 3 60  ? 197.402 269.917 383.799 1.00 37.82 ? 60  GLN C CB  1 
ATOM   4089 C CG  . GLN C 3 60  ? 196.806 270.469 385.083 1.00 38.48 ? 60  GLN C CG  1 
ATOM   4090 C CD  . GLN C 3 60  ? 197.785 270.441 386.243 1.00 41.25 ? 60  GLN C CD  1 
ATOM   4091 O OE1 . GLN C 3 60  ? 198.651 271.307 386.359 1.00 41.56 ? 60  GLN C OE1 1 
ATOM   4092 N NE2 . GLN C 3 60  ? 197.651 269.443 387.108 1.00 38.65 ? 60  GLN C NE2 1 
ATOM   4093 N N   . ARG C 3 61  ? 199.133 270.306 380.839 1.00 28.06 ? 61  ARG C N   1 
ATOM   4094 C CA  . ARG C 3 61  ? 199.786 269.517 379.804 1.00 27.41 ? 61  ARG C CA  1 
ATOM   4095 C C   . ARG C 3 61  ? 200.963 270.213 379.143 1.00 25.97 ? 61  ARG C C   1 
ATOM   4096 O O   . ARG C 3 61  ? 201.902 269.534 378.726 1.00 27.55 ? 61  ARG C O   1 
ATOM   4097 C CB  . ARG C 3 61  ? 198.780 269.128 378.715 1.00 25.37 ? 61  ARG C CB  1 
ATOM   4098 C CG  . ARG C 3 61  ? 197.831 268.013 379.110 1.00 24.90 ? 61  ARG C CG  1 
ATOM   4099 C CD  . ARG C 3 61  ? 196.937 267.625 377.948 1.00 29.06 ? 61  ARG C CD  1 
ATOM   4100 N NE  . ARG C 3 61  ? 196.016 266.548 378.289 1.00 31.98 ? 61  ARG C NE  1 
ATOM   4101 C CZ  . ARG C 3 61  ? 196.115 265.293 377.868 1.00 27.50 ? 61  ARG C CZ  1 
ATOM   4102 N NH1 . ARG C 3 61  ? 197.089 264.903 377.063 1.00 28.07 ? 61  ARG C NH1 1 
ATOM   4103 N NH2 . ARG C 3 61  ? 195.208 264.406 378.262 1.00 29.51 ? 61  ARG C NH2 1 
ATOM   4104 N N   . LYS C 3 62  ? 200.942 271.539 379.036 1.00 26.37 ? 62  LYS C N   1 
ATOM   4105 C CA  . LYS C 3 62  ? 202.009 272.241 378.334 1.00 27.62 ? 62  LYS C CA  1 
ATOM   4106 C C   . LYS C 3 62  ? 203.350 271.990 379.012 1.00 24.30 ? 62  LYS C C   1 
ATOM   4107 O O   . LYS C 3 62  ? 203.447 271.937 380.241 1.00 24.27 ? 62  LYS C O   1 
ATOM   4108 C CB  . LYS C 3 62  ? 201.713 273.741 378.274 1.00 26.05 ? 62  LYS C CB  1 
ATOM   4109 C CG  . LYS C 3 62  ? 201.575 274.432 379.622 1.00 25.77 ? 62  LYS C CG  1 
ATOM   4110 C CD  . LYS C 3 62  ? 201.199 275.895 379.438 1.00 25.22 ? 62  LYS C CD  1 
ATOM   4111 C CE  . LYS C 3 62  ? 200.889 276.587 380.753 1.00 27.15 ? 62  LYS C CE  1 
ATOM   4112 N NZ  . LYS C 3 62  ? 202.077 276.724 381.630 1.00 30.34 ? 62  LYS C NZ  1 
ATOM   4113 N N   . ASN C 3 63  ? 204.390 271.821 378.193 1.00 24.15 ? 63  ASN C N   1 
ATOM   4114 C CA  . ASN C 3 63  ? 205.749 271.581 378.668 1.00 23.37 ? 63  ASN C CA  1 
ATOM   4115 C C   . ASN C 3 63  ? 205.883 270.215 379.334 1.00 18.01 ? 63  ASN C C   1 
ATOM   4116 O O   . ASN C 3 63  ? 206.646 270.048 380.285 1.00 22.74 ? 63  ASN C O   1 
ATOM   4117 C CB  . ASN C 3 63  ? 206.202 272.694 379.616 1.00 22.88 ? 63  ASN C CB  1 
ATOM   4118 C CG  . ASN C 3 63  ? 205.984 274.073 379.027 1.00 23.46 ? 63  ASN C CG  1 
ATOM   4119 O OD1 . ASN C 3 63  ? 206.442 274.367 377.926 1.00 21.61 ? 63  ASN C OD1 1 
ATOM   4120 N ND2 . ASN C 3 63  ? 205.256 274.916 379.746 1.00 26.33 ? 63  ASN C ND2 1 
ATOM   4121 N N   . THR C 3 64  ? 205.119 269.243 378.844 1.00 22.83 ? 64  THR C N   1 
ATOM   4122 C CA  . THR C 3 64  ? 205.258 267.840 379.201 1.00 20.14 ? 64  THR C CA  1 
ATOM   4123 C C   . THR C 3 64  ? 205.026 267.032 377.933 1.00 20.30 ? 64  THR C C   1 
ATOM   4124 O O   . THR C 3 64  ? 204.825 267.591 376.853 1.00 24.92 ? 64  THR C O   1 
ATOM   4125 C CB  . THR C 3 64  ? 204.280 267.430 380.309 1.00 23.31 ? 64  THR C CB  1 
ATOM   4126 O OG1 . THR C 3 64  ? 202.948 267.385 379.786 1.00 27.23 ? 64  THR C OG1 1 
ATOM   4127 C CG2 . THR C 3 64  ? 204.327 268.413 381.464 1.00 22.00 ? 64  THR C CG2 1 
ATOM   4128 N N   . MET C 3 65  ? 205.052 265.706 378.052 1.00 19.20 ? 65  MET C N   1 
ATOM   4129 C CA  . MET C 3 65  ? 204.735 264.880 376.892 1.00 20.49 ? 65  MET C CA  1 
ATOM   4130 C C   . MET C 3 65  ? 203.237 264.869 376.610 1.00 23.72 ? 65  MET C C   1 
ATOM   4131 O O   . MET C 3 65  ? 202.825 264.712 375.454 1.00 25.69 ? 65  MET C O   1 
ATOM   4132 C CB  . MET C 3 65  ? 205.256 263.459 377.098 1.00 25.64 ? 65  MET C CB  1 
ATOM   4133 C CG  . MET C 3 65  ? 206.763 263.370 377.265 1.00 14.83 ? 65  MET C CG  1 
ATOM   4134 S SD  . MET C 3 65  ? 207.698 264.139 375.930 1.00 28.67 ? 65  MET C SD  1 
ATOM   4135 C CE  . MET C 3 65  ? 207.178 263.167 374.525 1.00 18.63 ? 65  MET C CE  1 
ATOM   4136 N N   . ASP C 3 66  ? 202.414 265.076 377.640 1.00 24.52 ? 66  ASP C N   1 
ATOM   4137 C CA  . ASP C 3 66  ? 200.968 265.038 377.462 1.00 19.00 ? 66  ASP C CA  1 
ATOM   4138 C C   . ASP C 3 66  ? 200.468 266.102 376.498 1.00 24.51 ? 66  ASP C C   1 
ATOM   4139 O O   . ASP C 3 66  ? 199.359 265.968 375.972 1.00 26.65 ? 66  ASP C O   1 
ATOM   4140 C CB  . ASP C 3 66  ? 200.270 265.202 378.810 1.00 23.99 ? 66  ASP C CB  1 
ATOM   4141 C CG  . ASP C 3 66  ? 200.339 263.954 379.656 1.00 31.06 ? 66  ASP C CG  1 
ATOM   4142 O OD1 . ASP C 3 66  ? 200.269 262.845 379.088 1.00 33.66 ? 66  ASP C OD1 1 
ATOM   4143 O OD2 . ASP C 3 66  ? 200.461 264.080 380.891 1.00 30.77 ? 66  ASP C OD2 1 
ATOM   4144 N N   . MET C 3 67  ? 201.251 267.151 376.248 1.00 21.35 ? 67  MET C N   1 
ATOM   4145 C CA  . MET C 3 67  ? 200.822 268.169 375.300 1.00 21.13 ? 67  MET C CA  1 
ATOM   4146 C C   . MET C 3 67  ? 200.801 267.662 373.867 1.00 19.70 ? 67  MET C C   1 
ATOM   4147 O O   . MET C 3 67  ? 200.271 268.357 372.996 1.00 22.18 ? 67  MET C O   1 
ATOM   4148 C CB  . MET C 3 67  ? 201.722 269.402 375.394 1.00 19.67 ? 67  MET C CB  1 
ATOM   4149 C CG  . MET C 3 67  ? 203.103 269.235 374.785 1.00 25.17 ? 67  MET C CG  1 
ATOM   4150 S SD  . MET C 3 67  ? 204.193 270.608 375.201 1.00 26.00 ? 67  MET C SD  1 
ATOM   4151 C CE  . MET C 3 67  ? 205.740 270.039 374.508 1.00 21.83 ? 67  MET C CE  1 
ATOM   4152 N N   . TYR C 3 68  ? 201.359 266.484 373.594 1.00 20.00 ? 68  TYR C N   1 
ATOM   4153 C CA  . TYR C 3 68  ? 201.344 265.936 372.246 1.00 16.93 ? 68  TYR C CA  1 
ATOM   4154 C C   . TYR C 3 68  ? 200.183 264.984 371.993 1.00 21.28 ? 68  TYR C C   1 
ATOM   4155 O O   . TYR C 3 68  ? 199.984 264.573 370.847 1.00 23.41 ? 68  TYR C O   1 
ATOM   4156 C CB  . TYR C 3 68  ? 202.659 265.206 371.954 1.00 16.61 ? 68  TYR C CB  1 
ATOM   4157 C CG  . TYR C 3 68  ? 203.854 266.119 371.839 1.00 18.94 ? 68  TYR C CG  1 
ATOM   4158 C CD1 . TYR C 3 68  ? 204.005 266.961 370.744 1.00 15.23 ? 68  TYR C CD1 1 
ATOM   4159 C CD2 . TYR C 3 68  ? 204.837 266.133 372.817 1.00 17.15 ? 68  TYR C CD2 1 
ATOM   4160 C CE1 . TYR C 3 68  ? 205.097 267.795 370.633 1.00 18.98 ? 68  TYR C CE1 1 
ATOM   4161 C CE2 . TYR C 3 68  ? 205.931 266.962 372.714 1.00 17.72 ? 68  TYR C CE2 1 
ATOM   4162 C CZ  . TYR C 3 68  ? 206.056 267.792 371.620 1.00 19.62 ? 68  TYR C CZ  1 
ATOM   4163 O OH  . TYR C 3 68  ? 207.148 268.619 371.517 1.00 20.86 ? 68  TYR C OH  1 
ATOM   4164 N N   . ARG C 3 69  ? 199.412 264.636 373.017 1.00 22.49 ? 69  ARG C N   1 
ATOM   4165 C CA  . ARG C 3 69  ? 198.383 263.609 372.926 1.00 17.10 ? 69  ARG C CA  1 
ATOM   4166 C C   . ARG C 3 69  ? 197.009 264.258 372.984 1.00 19.68 ? 69  ARG C C   1 
ATOM   4167 O O   . ARG C 3 69  ? 196.744 265.075 373.870 1.00 24.47 ? 69  ARG C O   1 
ATOM   4168 C CB  . ARG C 3 69  ? 198.533 262.595 374.057 1.00 16.05 ? 69  ARG C CB  1 
ATOM   4169 C CG  . ARG C 3 69  ? 199.827 261.821 374.027 1.00 21.26 ? 69  ARG C CG  1 
ATOM   4170 C CD  . ARG C 3 69  ? 200.320 261.518 375.425 1.00 20.70 ? 69  ARG C CD  1 
ATOM   4171 N NE  . ARG C 3 69  ? 201.670 260.972 375.411 1.00 26.10 ? 69  ARG C NE  1 
ATOM   4172 C CZ  . ARG C 3 69  ? 202.476 260.934 376.462 1.00 27.78 ? 69  ARG C CZ  1 
ATOM   4173 N NH1 . ARG C 3 69  ? 202.105 261.416 377.636 1.00 27.89 ? 69  ARG C NH1 1 
ATOM   4174 N NH2 . ARG C 3 69  ? 203.689 260.406 376.330 1.00 23.63 ? 69  ARG C NH2 1 
ATOM   4175 N N   . VAL C 3 70  ? 196.138 263.888 372.049 1.00 17.86 ? 70  VAL C N   1 
ATOM   4176 C CA  . VAL C 3 70  ? 194.741 264.308 372.077 1.00 18.00 ? 70  VAL C CA  1 
ATOM   4177 C C   . VAL C 3 70  ? 193.891 263.079 372.359 1.00 21.50 ? 70  VAL C C   1 
ATOM   4178 O O   . VAL C 3 70  ? 193.970 262.082 371.636 1.00 22.86 ? 70  VAL C O   1 
ATOM   4179 C CB  . VAL C 3 70  ? 194.330 264.988 370.762 1.00 19.73 ? 70  VAL C CB  1 
ATOM   4180 C CG1 . VAL C 3 70  ? 192.845 265.299 370.763 1.00 14.61 ? 70  VAL C CG1 1 
ATOM   4181 C CG2 . VAL C 3 70  ? 195.139 266.254 370.556 1.00 18.54 ? 70  VAL C CG2 1 
ATOM   4182 N N   . GLU C 3 71  ? 193.073 263.144 373.403 1.00 24.72 ? 71  GLU C N   1 
ATOM   4183 C CA  . GLU C 3 71  ? 192.343 261.970 373.860 1.00 19.87 ? 71  GLU C CA  1 
ATOM   4184 C C   . GLU C 3 71  ? 191.006 261.830 373.141 1.00 19.38 ? 71  GLU C C   1 
ATOM   4185 O O   . GLU C 3 71  ? 190.211 262.772 373.096 1.00 19.18 ? 71  GLU C O   1 
ATOM   4186 C CB  . GLU C 3 71  ? 192.109 262.042 375.366 1.00 17.57 ? 71  GLU C CB  1 
ATOM   4187 C CG  . GLU C 3 71  ? 191.846 260.689 375.996 1.00 23.13 ? 71  GLU C CG  1 
ATOM   4188 C CD  . GLU C 3 71  ? 190.887 260.763 377.163 1.00 29.23 ? 71  GLU C CD  1 
ATOM   4189 O OE1 . GLU C 3 71  ? 189.673 260.933 376.925 1.00 28.85 ? 71  GLU C OE1 1 
ATOM   4190 O OE2 . GLU C 3 71  ? 191.346 260.661 378.319 1.00 33.84 ? 71  GLU C OE2 1 
ATOM   4191 N N   . LEU C 3 72  ? 190.768 260.647 372.583 1.00 21.72 ? 72  LEU C N   1 
ATOM   4192 C CA  . LEU C 3 72  ? 189.456 260.208 372.135 1.00 21.42 ? 72  LEU C CA  1 
ATOM   4193 C C   . LEU C 3 72  ? 188.895 259.192 373.122 1.00 23.55 ? 72  LEU C C   1 
ATOM   4194 O O   . LEU C 3 72  ? 189.634 258.520 373.846 1.00 29.34 ? 72  LEU C O   1 
ATOM   4195 C CB  . LEU C 3 72  ? 189.528 259.573 370.744 1.00 19.95 ? 72  LEU C CB  1 
ATOM   4196 C CG  . LEU C 3 72  ? 190.253 260.322 369.631 1.00 22.04 ? 72  LEU C CG  1 
ATOM   4197 C CD1 . LEU C 3 72  ? 190.299 259.463 368.385 1.00 24.28 ? 72  LEU C CD1 1 
ATOM   4198 C CD2 . LEU C 3 72  ? 189.585 261.652 369.341 1.00 23.76 ? 72  LEU C CD2 1 
ATOM   4199 N N   . ASN C 3 73  ? 187.571 259.078 373.138 1.00 18.15 ? 73  ASN C N   1 
ATOM   4200 C CA  . ASN C 3 73  ? 186.887 258.063 373.926 1.00 23.32 ? 73  ASN C CA  1 
ATOM   4201 C C   . ASN C 3 73  ? 185.826 257.396 373.060 1.00 24.75 ? 73  ASN C C   1 
ATOM   4202 O O   . ASN C 3 73  ? 185.633 257.745 371.893 1.00 26.92 ? 73  ASN C O   1 
ATOM   4203 C CB  . ASN C 3 73  ? 186.277 258.657 375.204 1.00 22.66 ? 73  ASN C CB  1 
ATOM   4204 C CG  . ASN C 3 73  ? 185.330 259.798 374.927 1.00 25.03 ? 73  ASN C CG  1 
ATOM   4205 O OD1 . ASN C 3 73  ? 184.745 259.894 373.851 1.00 26.94 ? 73  ASN C OD1 1 
ATOM   4206 N ND2 . ASN C 3 73  ? 185.173 260.677 375.905 1.00 29.29 ? 73  ASN C ND2 1 
ATOM   4207 N N   . ASP C 3 74  ? 185.142 256.412 373.637 1.00 26.03 ? 74  ASP C N   1 
ATOM   4208 C CA  . ASP C 3 74  ? 184.115 255.653 372.938 1.00 24.06 ? 74  ASP C CA  1 
ATOM   4209 C C   . ASP C 3 74  ? 182.706 256.124 373.278 1.00 22.50 ? 74  ASP C C   1 
ATOM   4210 O O   . ASP C 3 74  ? 181.754 255.357 373.116 1.00 25.53 ? 74  ASP C O   1 
ATOM   4211 C CB  . ASP C 3 74  ? 184.254 254.164 373.257 1.00 19.40 ? 74  ASP C CB  1 
ATOM   4212 C CG  . ASP C 3 74  ? 183.717 253.809 374.630 1.00 26.29 ? 74  ASP C CG  1 
ATOM   4213 O OD1 . ASP C 3 74  ? 183.878 254.617 375.567 1.00 29.88 ? 74  ASP C OD1 1 
ATOM   4214 O OD2 . ASP C 3 74  ? 183.123 252.722 374.768 1.00 30.06 ? 74  ASP C OD2 1 
ATOM   4215 N N   . ALA C 3 75  ? 182.551 257.363 373.738 1.00 25.95 ? 75  ALA C N   1 
ATOM   4216 C CA  . ALA C 3 75  ? 181.241 257.881 374.112 1.00 22.58 ? 75  ALA C CA  1 
ATOM   4217 C C   . ALA C 3 75  ? 180.327 257.988 372.898 1.00 26.16 ? 75  ALA C C   1 
ATOM   4218 O O   . ALA C 3 75  ? 180.752 257.732 371.767 1.00 30.84 ? 75  ALA C O   1 
ATOM   4219 C CB  . ALA C 3 75  ? 181.382 259.244 374.788 1.00 24.74 ? 75  ALA C CB  1 
ATOM   4220 N N   . ALA C 3 76  ? 179.073 258.366 373.123 1.00 21.93 ? 76  ALA C N   1 
ATOM   4221 C CA  . ALA C 3 76  ? 178.103 258.450 372.045 1.00 21.68 ? 76  ALA C CA  1 
ATOM   4222 C C   . ALA C 3 76  ? 178.487 259.546 371.057 1.00 26.49 ? 76  ALA C C   1 
ATOM   4223 O O   . ALA C 3 76  ? 179.193 260.502 371.388 1.00 26.75 ? 76  ALA C O   1 
ATOM   4224 C CB  . ALA C 3 76  ? 176.705 258.719 372.600 1.00 21.39 ? 76  ALA C CB  1 
ATOM   4225 N N   . HIS C 3 77  ? 178.000 259.400 369.827 1.00 25.28 ? 77  HIS C N   1 
ATOM   4226 C CA  . HIS C 3 77  ? 178.326 260.357 368.779 1.00 25.81 ? 77  HIS C CA  1 
ATOM   4227 C C   . HIS C 3 77  ? 177.893 261.762 369.176 1.00 25.96 ? 77  HIS C C   1 
ATOM   4228 O O   . HIS C 3 77  ? 176.843 261.958 369.795 1.00 29.20 ? 77  HIS C O   1 
ATOM   4229 C CB  . HIS C 3 77  ? 177.677 259.950 367.457 1.00 18.89 ? 77  HIS C CB  1 
ATOM   4230 C CG  . HIS C 3 77  ? 177.921 260.922 366.345 1.00 26.59 ? 77  HIS C CG  1 
ATOM   4231 N ND1 . HIS C 3 77  ? 177.079 261.981 366.083 1.00 33.21 ? 77  HIS C ND1 1 
ATOM   4232 C CD2 . HIS C 3 77  ? 178.917 261.000 365.430 1.00 26.43 ? 77  HIS C CD2 1 
ATOM   4233 C CE1 . HIS C 3 77  ? 177.549 262.673 365.062 1.00 23.47 ? 77  HIS C CE1 1 
ATOM   4234 N NE2 . HIS C 3 77  ? 178.663 262.098 364.647 1.00 24.39 ? 77  HIS C NE2 1 
ATOM   4235 N N   . SER C 3 78  ? 178.720 262.742 368.820 1.00 27.21 ? 78  SER C N   1 
ATOM   4236 C CA  . SER C 3 78  ? 178.413 264.149 369.024 1.00 28.78 ? 78  SER C CA  1 
ATOM   4237 C C   . SER C 3 78  ? 179.029 264.951 367.886 1.00 31.62 ? 78  SER C C   1 
ATOM   4238 O O   . SER C 3 78  ? 179.939 264.489 367.194 1.00 33.13 ? 78  SER C O   1 
ATOM   4239 C CB  . SER C 3 78  ? 178.926 264.650 370.379 1.00 32.78 ? 78  SER C CB  1 
ATOM   4240 O OG  . SER C 3 78  ? 180.337 264.550 370.458 1.00 31.73 ? 78  SER C OG  1 
ATOM   4241 N N   . ASP C 3 79  ? 178.517 266.165 367.693 1.00 29.33 ? 79  ASP C N   1 
ATOM   4242 C CA  . ASP C 3 79  ? 179.020 267.074 366.673 1.00 25.05 ? 79  ASP C CA  1 
ATOM   4243 C C   . ASP C 3 79  ? 180.027 268.075 367.219 1.00 28.21 ? 79  ASP C C   1 
ATOM   4244 O O   . ASP C 3 79  ? 180.454 268.967 366.482 1.00 32.20 ? 79  ASP C O   1 
ATOM   4245 C CB  . ASP C 3 79  ? 177.858 267.823 366.012 1.00 30.14 ? 79  ASP C CB  1 
ATOM   4246 C CG  . ASP C 3 79  ? 177.003 266.923 365.137 1.00 35.87 ? 79  ASP C CG  1 
ATOM   4247 O OD1 . ASP C 3 79  ? 177.553 265.984 364.524 1.00 33.61 ? 79  ASP C OD1 1 
ATOM   4248 O OD2 . ASP C 3 79  ? 175.779 267.159 365.061 1.00 34.62 ? 79  ASP C OD2 1 
ATOM   4249 N N   . THR C 3 80  ? 180.404 267.958 368.486 1.00 28.80 ? 80  THR C N   1 
ATOM   4250 C CA  . THR C 3 80  ? 181.419 268.833 369.051 1.00 29.02 ? 80  THR C CA  1 
ATOM   4251 C C   . THR C 3 80  ? 182.776 268.542 368.410 1.00 26.92 ? 80  THR C C   1 
ATOM   4252 O O   . THR C 3 80  ? 183.100 267.381 368.149 1.00 29.29 ? 80  THR C O   1 
ATOM   4253 C CB  . THR C 3 80  ? 181.500 268.634 370.564 1.00 32.79 ? 80  THR C CB  1 
ATOM   4254 O OG1 . THR C 3 80  ? 180.197 268.799 371.136 1.00 36.30 ? 80  THR C OG1 1 
ATOM   4255 C CG2 . THR C 3 80  ? 182.452 269.632 371.200 1.00 30.08 ? 80  THR C CG2 1 
ATOM   4256 N N   . PRO C 3 81  ? 183.582 269.565 368.132 1.00 22.74 ? 81  PRO C N   1 
ATOM   4257 C CA  . PRO C 3 81  ? 184.905 269.314 367.553 1.00 19.36 ? 81  PRO C CA  1 
ATOM   4258 C C   . PRO C 3 81  ? 185.838 268.612 368.525 1.00 19.79 ? 81  PRO C C   1 
ATOM   4259 O O   . PRO C 3 81  ? 185.775 268.804 369.741 1.00 23.01 ? 81  PRO C O   1 
ATOM   4260 C CB  . PRO C 3 81  ? 185.415 270.718 367.210 1.00 22.14 ? 81  PRO C CB  1 
ATOM   4261 C CG  . PRO C 3 81  ? 184.648 271.627 368.095 1.00 23.47 ? 81  PRO C CG  1 
ATOM   4262 C CD  . PRO C 3 81  ? 183.303 271.006 368.247 1.00 22.26 ? 81  PRO C CD  1 
ATOM   4263 N N   . ILE C 3 82  ? 186.717 267.786 367.964 1.00 20.59 ? 82  ILE C N   1 
ATOM   4264 C CA  . ILE C 3 82  ? 187.761 267.160 368.763 1.00 22.47 ? 82  ILE C CA  1 
ATOM   4265 C C   . ILE C 3 82  ? 188.931 268.116 368.942 1.00 20.76 ? 82  ILE C C   1 
ATOM   4266 O O   . ILE C 3 82  ? 189.468 268.258 370.045 1.00 20.23 ? 82  ILE C O   1 
ATOM   4267 C CB  . ILE C 3 82  ? 188.200 265.835 368.112 1.00 19.17 ? 82  ILE C CB  1 
ATOM   4268 C CG1 . ILE C 3 82  ? 187.049 264.825 368.135 1.00 14.77 ? 82  ILE C CG1 1 
ATOM   4269 C CG2 . ILE C 3 82  ? 189.432 265.278 368.817 1.00 17.07 ? 82  ILE C CG2 1 
ATOM   4270 C CD1 . ILE C 3 82  ? 187.217 263.679 367.167 1.00 14.28 ? 82  ILE C CD1 1 
ATOM   4271 N N   . LEU C 3 83  ? 189.338 268.786 367.866 1.00 19.08 ? 83  LEU C N   1 
ATOM   4272 C CA  . LEU C 3 83  ? 190.411 269.764 367.928 1.00 17.59 ? 83  LEU C CA  1 
ATOM   4273 C C   . LEU C 3 83  ? 190.140 270.870 366.919 1.00 19.10 ? 83  LEU C C   1 
ATOM   4274 O O   . LEU C 3 83  ? 189.509 270.647 365.877 1.00 16.50 ? 83  LEU C O   1 
ATOM   4275 C CB  . LEU C 3 83  ? 191.777 269.122 367.658 1.00 17.01 ? 83  LEU C CB  1 
ATOM   4276 C CG  . LEU C 3 83  ? 191.997 268.563 366.252 1.00 21.37 ? 83  LEU C CG  1 
ATOM   4277 C CD1 . LEU C 3 83  ? 192.631 269.599 365.328 1.00 17.70 ? 83  LEU C CD1 1 
ATOM   4278 C CD2 . LEU C 3 83  ? 192.841 267.305 366.314 1.00 18.03 ? 83  LEU C CD2 1 
ATOM   4279 N N   . CYS C 3 84  ? 190.649 272.060 367.248 1.00 25.83 ? 84  CYS C N   1 
ATOM   4280 C CA  . CYS C 3 84  ? 190.512 273.269 366.443 1.00 16.17 ? 84  CYS C CA  1 
ATOM   4281 C C   . CYS C 3 84  ? 191.879 273.928 366.330 1.00 20.19 ? 84  CYS C C   1 
ATOM   4282 O O   . CYS C 3 84  ? 192.546 274.149 367.345 1.00 24.33 ? 84  CYS C O   1 
ATOM   4283 C CB  . CYS C 3 84  ? 189.504 274.233 367.079 1.00 18.07 ? 84  CYS C CB  1 
ATOM   4284 S SG  . CYS C 3 84  ? 187.804 273.631 367.118 1.00 41.68 ? 84  CYS C SG  1 
ATOM   4285 N N   . LEU C 3 85  ? 192.290 274.251 365.105 1.00 21.12 ? 85  LEU C N   1 
ATOM   4286 C CA  . LEU C 3 85  ? 193.602 274.822 364.827 1.00 16.58 ? 85  LEU C CA  1 
ATOM   4287 C C   . LEU C 3 85  ? 193.464 275.977 363.848 1.00 22.57 ? 85  LEU C C   1 
ATOM   4288 O O   . LEU C 3 85  ? 192.689 275.892 362.894 1.00 19.72 ? 85  LEU C O   1 
ATOM   4289 C CB  . LEU C 3 85  ? 194.544 273.767 364.238 1.00 18.68 ? 85  LEU C CB  1 
ATOM   4290 C CG  . LEU C 3 85  ? 195.556 273.116 365.176 1.00 24.18 ? 85  LEU C CG  1 
ATOM   4291 C CD1 . LEU C 3 85  ? 196.248 271.971 364.466 1.00 22.85 ? 85  LEU C CD1 1 
ATOM   4292 C CD2 . LEU C 3 85  ? 196.570 274.133 365.661 1.00 24.05 ? 85  LEU C CD2 1 
ATOM   4293 N N   . SER C 3 86  ? 194.218 277.047 364.075 1.00 24.19 ? 86  SER C N   1 
ATOM   4294 C CA  . SER C 3 86  ? 194.321 278.113 363.090 1.00 13.81 ? 86  SER C CA  1 
ATOM   4295 C C   . SER C 3 86  ? 195.464 277.820 362.131 1.00 15.99 ? 86  SER C C   1 
ATOM   4296 O O   . SER C 3 86  ? 196.540 277.383 362.543 1.00 21.94 ? 86  SER C O   1 
ATOM   4297 C CB  . SER C 3 86  ? 194.542 279.461 363.771 1.00 21.06 ? 86  SER C CB  1 
ATOM   4298 O OG  . SER C 3 86  ? 193.375 279.884 364.445 1.00 31.79 ? 86  SER C OG  1 
ATOM   4299 N N   . LEU C 3 87  ? 195.226 278.053 360.841 1.00 16.86 ? 87  LEU C N   1 
ATOM   4300 C CA  . LEU C 3 87  ? 196.249 277.828 359.822 1.00 16.34 ? 87  LEU C CA  1 
ATOM   4301 C C   . LEU C 3 87  ? 197.212 279.016 359.778 1.00 21.24 ? 87  LEU C C   1 
ATOM   4302 O O   . LEU C 3 87  ? 197.298 279.762 358.804 1.00 23.73 ? 87  LEU C O   1 
ATOM   4303 C CB  . LEU C 3 87  ? 195.607 277.583 358.463 1.00 21.15 ? 87  LEU C CB  1 
ATOM   4304 C CG  . LEU C 3 87  ? 196.578 277.078 357.394 1.00 21.34 ? 87  LEU C CG  1 
ATOM   4305 C CD1 . LEU C 3 87  ? 196.789 275.580 357.540 1.00 19.97 ? 87  LEU C CD1 1 
ATOM   4306 C CD2 . LEU C 3 87  ? 196.098 277.427 355.994 1.00 22.28 ? 87  LEU C CD2 1 
ATOM   4307 N N   . SER C 3 88  ? 197.947 279.179 360.879 1.00 19.22 ? 88  SER C N   1 
ATOM   4308 C CA  . SER C 3 88  ? 198.965 280.216 361.038 1.00 14.97 ? 88  SER C CA  1 
ATOM   4309 C C   . SER C 3 88  ? 200.246 279.514 361.468 1.00 17.36 ? 88  SER C C   1 
ATOM   4310 O O   . SER C 3 88  ? 200.601 279.518 362.655 1.00 19.99 ? 88  SER C O   1 
ATOM   4311 C CB  . SER C 3 88  ? 198.538 281.271 362.055 1.00 13.76 ? 88  SER C CB  1 
ATOM   4312 O OG  . SER C 3 88  ? 197.342 281.907 361.651 1.00 25.63 ? 88  SER C OG  1 
ATOM   4313 N N   . PRO C 3 89  ? 200.972 278.906 360.526 1.00 10.44 ? 89  PRO C N   1 
ATOM   4314 C CA  . PRO C 3 89  ? 202.016 277.943 360.905 1.00 11.83 ? 89  PRO C CA  1 
ATOM   4315 C C   . PRO C 3 89  ? 203.178 278.542 361.681 1.00 19.86 ? 89  PRO C C   1 
ATOM   4316 O O   . PRO C 3 89  ? 203.934 277.778 362.291 1.00 19.13 ? 89  PRO C O   1 
ATOM   4317 C CB  . PRO C 3 89  ? 202.476 277.381 359.556 1.00 13.96 ? 89  PRO C CB  1 
ATOM   4318 C CG  . PRO C 3 89  ? 202.152 278.439 358.572 1.00 21.25 ? 89  PRO C CG  1 
ATOM   4319 C CD  . PRO C 3 89  ? 200.921 279.123 359.070 1.00 17.34 ? 89  PRO C CD  1 
ATOM   4320 N N   . ALA C 3 90  ? 203.352 279.865 361.682 1.00 17.77 ? 90  ALA C N   1 
ATOM   4321 C CA  . ALA C 3 90  ? 204.443 280.500 362.404 1.00 9.09  ? 90  ALA C CA  1 
ATOM   4322 C C   . ALA C 3 90  ? 204.007 281.266 363.642 1.00 13.21 ? 90  ALA C C   1 
ATOM   4323 O O   . ALA C 3 90  ? 204.860 281.591 364.473 1.00 21.91 ? 90  ALA C O   1 
ATOM   4324 C CB  . ALA C 3 90  ? 205.210 281.459 361.480 1.00 17.24 ? 90  ALA C CB  1 
ATOM   4325 N N   . SER C 3 91  ? 202.723 281.564 363.796 1.00 19.13 ? 91  SER C N   1 
ATOM   4326 C CA  . SER C 3 91  ? 202.251 282.379 364.905 1.00 21.65 ? 91  SER C CA  1 
ATOM   4327 C C   . SER C 3 91  ? 201.263 281.670 365.815 1.00 17.17 ? 91  SER C C   1 
ATOM   4328 O O   . SER C 3 91  ? 201.103 282.088 366.962 1.00 23.91 ? 91  SER C O   1 
ATOM   4329 C CB  . SER C 3 91  ? 201.610 283.671 364.376 1.00 18.82 ? 91  SER C CB  1 
ATOM   4330 O OG  . SER C 3 91  ? 200.653 283.392 363.373 1.00 30.14 ? 91  SER C OG  1 
ATOM   4331 N N   . ASP C 3 92  ? 200.601 280.622 365.350 1.00 20.55 ? 92  ASP C N   1 
ATOM   4332 C CA  . ASP C 3 92  ? 199.767 279.815 366.233 1.00 17.76 ? 92  ASP C CA  1 
ATOM   4333 C C   . ASP C 3 92  ? 200.674 279.079 367.212 1.00 19.20 ? 92  ASP C C   1 
ATOM   4334 O O   . ASP C 3 92  ? 201.577 278.357 366.774 1.00 22.78 ? 92  ASP C O   1 
ATOM   4335 C CB  . ASP C 3 92  ? 198.931 278.829 365.418 1.00 20.33 ? 92  ASP C CB  1 
ATOM   4336 C CG  . ASP C 3 92  ? 197.915 278.076 366.261 1.00 25.05 ? 92  ASP C CG  1 
ATOM   4337 O OD1 . ASP C 3 92  ? 198.202 277.766 367.434 1.00 23.52 ? 92  ASP C OD1 1 
ATOM   4338 O OD2 . ASP C 3 92  ? 196.820 277.786 365.742 1.00 32.82 ? 92  ASP C OD2 1 
ATOM   4339 N N   . PRO C 3 93  ? 200.478 279.216 368.527 1.00 16.99 ? 93  PRO C N   1 
ATOM   4340 C CA  . PRO C 3 93  ? 201.439 278.629 369.473 1.00 20.34 ? 93  PRO C CA  1 
ATOM   4341 C C   . PRO C 3 93  ? 201.569 277.117 369.361 1.00 18.42 ? 93  PRO C C   1 
ATOM   4342 O O   . PRO C 3 93  ? 202.576 276.551 369.795 1.00 25.64 ? 93  PRO C O   1 
ATOM   4343 C CB  . PRO C 3 93  ? 200.886 279.045 370.843 1.00 22.37 ? 93  PRO C CB  1 
ATOM   4344 C CG  . PRO C 3 93  ? 199.478 279.448 370.602 1.00 19.17 ? 93  PRO C CG  1 
ATOM   4345 C CD  . PRO C 3 93  ? 199.434 279.988 369.219 1.00 13.94 ? 93  PRO C CD  1 
ATOM   4346 N N   . ARG C 3 94  ? 200.570 276.449 368.793 1.00 17.34 ? 94  ARG C N   1 
ATOM   4347 C CA  . ARG C 3 94  ? 200.637 275.006 368.604 1.00 18.00 ? 94  ARG C CA  1 
ATOM   4348 C C   . ARG C 3 94  ? 201.442 274.595 367.378 1.00 18.03 ? 94  ARG C C   1 
ATOM   4349 O O   . ARG C 3 94  ? 201.934 273.463 367.334 1.00 18.54 ? 94  ARG C O   1 
ATOM   4350 C CB  . ARG C 3 94  ? 199.226 274.425 368.509 1.00 18.14 ? 94  ARG C CB  1 
ATOM   4351 C CG  . ARG C 3 94  ? 198.481 274.472 369.828 1.00 18.60 ? 94  ARG C CG  1 
ATOM   4352 C CD  . ARG C 3 94  ? 196.989 274.342 369.647 1.00 22.17 ? 94  ARG C CD  1 
ATOM   4353 N NE  . ARG C 3 94  ? 196.433 275.439 368.865 1.00 22.83 ? 94  ARG C NE  1 
ATOM   4354 C CZ  . ARG C 3 94  ? 195.144 275.740 368.808 1.00 18.93 ? 94  ARG C CZ  1 
ATOM   4355 N NH1 . ARG C 3 94  ? 194.244 275.057 369.494 1.00 21.69 ? 94  ARG C NH1 1 
ATOM   4356 N NH2 . ARG C 3 94  ? 194.748 276.756 368.049 1.00 17.35 ? 94  ARG C NH2 1 
ATOM   4357 N N   . LEU C 3 95  ? 201.593 275.475 366.389 1.00 17.00 ? 95  LEU C N   1 
ATOM   4358 C CA  . LEU C 3 95  ? 202.408 275.182 365.219 1.00 18.96 ? 95  LEU C CA  1 
ATOM   4359 C C   . LEU C 3 95  ? 203.736 275.923 365.204 1.00 17.96 ? 95  LEU C C   1 
ATOM   4360 O O   . LEU C 3 95  ? 204.626 275.538 364.442 1.00 15.89 ? 95  LEU C O   1 
ATOM   4361 C CB  . LEU C 3 95  ? 201.643 275.528 363.932 1.00 17.63 ? 95  LEU C CB  1 
ATOM   4362 C CG  . LEU C 3 95  ? 200.286 274.853 363.719 1.00 18.18 ? 95  LEU C CG  1 
ATOM   4363 C CD1 . LEU C 3 95  ? 199.666 275.325 362.415 1.00 17.73 ? 95  LEU C CD1 1 
ATOM   4364 C CD2 . LEU C 3 95  ? 200.409 273.340 363.734 1.00 17.28 ? 95  LEU C CD2 1 
ATOM   4365 N N   . ALA C 3 96  ? 203.899 276.951 366.038 1.00 16.33 ? 96  ALA C N   1 
ATOM   4366 C CA  . ALA C 3 96  ? 205.071 277.817 365.941 1.00 17.37 ? 96  ALA C CA  1 
ATOM   4367 C C   . ALA C 3 96  ? 206.361 277.067 366.259 1.00 21.38 ? 96  ALA C C   1 
ATOM   4368 O O   . ALA C 3 96  ? 207.404 277.335 365.654 1.00 22.33 ? 96  ALA C O   1 
ATOM   4369 C CB  . ALA C 3 96  ? 204.908 279.016 366.875 1.00 16.82 ? 96  ALA C CB  1 
ATOM   4370 N N   . HIS C 3 97  ? 206.314 276.127 367.202 1.00 18.77 ? 97  HIS C N   1 
ATOM   4371 C CA  . HIS C 3 97  ? 207.513 275.473 367.706 1.00 11.88 ? 97  HIS C CA  1 
ATOM   4372 C C   . HIS C 3 97  ? 207.745 274.092 367.109 1.00 11.82 ? 97  HIS C C   1 
ATOM   4373 O O   . HIS C 3 97  ? 208.599 273.354 367.601 1.00 21.45 ? 97  HIS C O   1 
ATOM   4374 C CB  . HIS C 3 97  ? 207.452 275.385 369.228 1.00 11.67 ? 97  HIS C CB  1 
ATOM   4375 C CG  . HIS C 3 97  ? 207.376 276.720 369.895 1.00 19.37 ? 97  HIS C CG  1 
ATOM   4376 N ND1 . HIS C 3 97  ? 206.193 277.410 370.045 1.00 23.29 ? 97  HIS C ND1 1 
ATOM   4377 C CD2 . HIS C 3 97  ? 208.339 277.502 370.436 1.00 18.97 ? 97  HIS C CD2 1 
ATOM   4378 C CE1 . HIS C 3 97  ? 206.429 278.554 370.660 1.00 19.74 ? 97  HIS C CE1 1 
ATOM   4379 N NE2 . HIS C 3 97  ? 207.723 278.634 370.908 1.00 20.54 ? 97  HIS C NE2 1 
ATOM   4380 N N   . THR C 3 98  ? 207.005 273.722 366.072 1.00 12.04 ? 98  THR C N   1 
ATOM   4381 C CA  . THR C 3 98  ? 207.380 272.570 365.274 1.00 8.91  ? 98  THR C CA  1 
ATOM   4382 C C   . THR C 3 98  ? 208.537 272.948 364.354 1.00 8.71  ? 98  THR C C   1 
ATOM   4383 O O   . THR C 3 98  ? 208.879 274.120 364.197 1.00 20.33 ? 98  THR C O   1 
ATOM   4384 C CB  . THR C 3 98  ? 206.187 272.060 364.464 1.00 15.85 ? 98  THR C CB  1 
ATOM   4385 O OG1 . THR C 3 98  ? 205.786 273.052 363.512 1.00 14.93 ? 98  THR C OG1 1 
ATOM   4386 C CG2 . THR C 3 98  ? 205.014 271.737 365.376 1.00 14.75 ? 98  THR C CG2 1 
ATOM   4387 N N   . MET C 3 99  ? 209.151 271.941 363.737 1.00 9.80  ? 99  MET C N   1 
ATOM   4388 C CA  . MET C 3 99  ? 210.267 272.216 362.840 1.00 10.56 ? 99  MET C CA  1 
ATOM   4389 C C   . MET C 3 99  ? 209.849 273.187 361.741 1.00 17.36 ? 99  MET C C   1 
ATOM   4390 O O   . MET C 3 99  ? 210.564 274.151 361.440 1.00 14.98 ? 99  MET C O   1 
ATOM   4391 C CB  . MET C 3 99  ? 210.797 270.909 362.250 1.00 7.93  ? 99  MET C CB  1 
ATOM   4392 C CG  . MET C 3 99  ? 211.916 271.086 361.235 1.00 16.80 ? 99  MET C CG  1 
ATOM   4393 S SD  . MET C 3 99  ? 213.309 272.064 361.838 1.00 37.60 ? 99  MET C SD  1 
ATOM   4394 C CE  . MET C 3 99  ? 214.140 270.892 362.894 1.00 11.85 ? 99  MET C CE  1 
ATOM   4395 N N   . LEU C 3 100 ? 208.677 272.960 361.145 1.00 19.26 ? 100 LEU C N   1 
ATOM   4396 C CA  . LEU C 3 100 ? 208.160 273.884 360.142 1.00 10.11 ? 100 LEU C CA  1 
ATOM   4397 C C   . LEU C 3 100 ? 208.035 275.292 360.710 1.00 15.44 ? 100 LEU C C   1 
ATOM   4398 O O   . LEU C 3 100 ? 208.481 276.264 360.091 1.00 14.65 ? 100 LEU C O   1 
ATOM   4399 C CB  . LEU C 3 100 ? 206.808 273.388 359.630 1.00 14.03 ? 100 LEU C CB  1 
ATOM   4400 C CG  . LEU C 3 100 ? 206.029 274.300 358.679 1.00 16.22 ? 100 LEU C CG  1 
ATOM   4401 C CD1 . LEU C 3 100 ? 206.698 274.372 357.322 1.00 17.15 ? 100 LEU C CD1 1 
ATOM   4402 C CD2 . LEU C 3 100 ? 204.600 273.818 358.551 1.00 21.27 ? 100 LEU C CD2 1 
ATOM   4403 N N   . GLY C 3 101 ? 207.432 275.420 361.892 1.00 16.10 ? 101 GLY C N   1 
ATOM   4404 C CA  . GLY C 3 101 ? 207.260 276.735 362.485 1.00 11.90 ? 101 GLY C CA  1 
ATOM   4405 C C   . GLY C 3 101 ? 208.577 277.389 362.853 1.00 14.83 ? 101 GLY C C   1 
ATOM   4406 O O   . GLY C 3 101 ? 208.742 278.603 362.702 1.00 20.02 ? 101 GLY C O   1 
ATOM   4407 N N   . GLU C 3 102 ? 209.529 276.598 363.349 1.00 16.70 ? 102 GLU C N   1 
ATOM   4408 C CA  . GLU C 3 102 ? 210.842 277.137 363.674 1.00 12.69 ? 102 GLU C CA  1 
ATOM   4409 C C   . GLU C 3 102 ? 211.536 277.675 362.431 1.00 12.46 ? 102 GLU C C   1 
ATOM   4410 O O   . GLU C 3 102 ? 212.139 278.753 362.468 1.00 15.41 ? 102 GLU C O   1 
ATOM   4411 C CB  . GLU C 3 102 ? 211.693 276.062 364.351 1.00 11.62 ? 102 GLU C CB  1 
ATOM   4412 C CG  . GLU C 3 102 ? 211.174 275.634 365.712 1.00 13.06 ? 102 GLU C CG  1 
ATOM   4413 C CD  . GLU C 3 102 ? 211.248 276.739 366.739 1.00 20.10 ? 102 GLU C CD  1 
ATOM   4414 O OE1 . GLU C 3 102 ? 211.915 277.753 366.471 1.00 25.37 ? 102 GLU C OE1 1 
ATOM   4415 O OE2 . GLU C 3 102 ? 210.640 276.600 367.816 1.00 20.16 ? 102 GLU C OE2 1 
ATOM   4416 N N   . ILE C 3 103 ? 211.460 276.946 361.318 1.00 11.21 ? 103 ILE C N   1 
ATOM   4417 C CA  . ILE C 3 103 ? 212.021 277.459 360.072 1.00 10.32 ? 103 ILE C CA  1 
ATOM   4418 C C   . ILE C 3 103 ? 211.290 278.726 359.645 1.00 12.06 ? 103 ILE C C   1 
ATOM   4419 O O   . ILE C 3 103 ? 211.911 279.706 359.219 1.00 17.33 ? 103 ILE C O   1 
ATOM   4420 C CB  . ILE C 3 103 ? 211.972 276.382 358.972 1.00 9.01  ? 103 ILE C CB  1 
ATOM   4421 C CG1 . ILE C 3 103 ? 212.761 275.136 359.385 1.00 18.34 ? 103 ILE C CG1 1 
ATOM   4422 C CG2 . ILE C 3 103 ? 212.512 276.936 357.663 1.00 13.33 ? 103 ILE C CG2 1 
ATOM   4423 C CD1 . ILE C 3 103 ? 214.258 275.335 359.473 1.00 17.46 ? 103 ILE C CD1 1 
ATOM   4424 N N   . LEU C 3 104 ? 209.959 278.726 359.749 1.00 16.89 ? 104 LEU C N   1 
ATOM   4425 C CA  . LEU C 3 104 ? 209.176 279.871 359.296 1.00 14.10 ? 104 LEU C CA  1 
ATOM   4426 C C   . LEU C 3 104 ? 209.489 281.124 360.098 1.00 14.17 ? 104 LEU C C   1 
ATOM   4427 O O   . LEU C 3 104 ? 209.413 282.234 359.564 1.00 13.90 ? 104 LEU C O   1 
ATOM   4428 C CB  . LEU C 3 104 ? 207.683 279.558 359.386 1.00 18.32 ? 104 LEU C CB  1 
ATOM   4429 C CG  . LEU C 3 104 ? 207.113 278.642 358.306 1.00 14.97 ? 104 LEU C CG  1 
ATOM   4430 C CD1 . LEU C 3 104 ? 205.726 278.186 358.689 1.00 19.87 ? 104 LEU C CD1 1 
ATOM   4431 C CD2 . LEU C 3 104 ? 207.081 279.347 356.975 1.00 13.53 ? 104 LEU C CD2 1 
ATOM   4432 N N   . ASN C 3 105 ? 209.837 280.974 361.371 1.00 12.14 ? 105 ASN C N   1 
ATOM   4433 C CA  . ASN C 3 105 ? 210.124 282.133 362.205 1.00 11.64 ? 105 ASN C CA  1 
ATOM   4434 C C   . ASN C 3 105 ? 211.471 282.778 361.899 1.00 13.04 ? 105 ASN C C   1 
ATOM   4435 O O   . ASN C 3 105 ? 211.819 283.773 362.539 1.00 9.77  ? 105 ASN C O   1 
ATOM   4436 C CB  . ASN C 3 105 ? 210.049 281.743 363.679 1.00 10.24 ? 105 ASN C CB  1 
ATOM   4437 C CG  . ASN C 3 105 ? 208.639 281.802 364.213 1.00 15.76 ? 105 ASN C CG  1 
ATOM   4438 O OD1 . ASN C 3 105 ? 208.199 282.832 364.716 1.00 24.56 ? 105 ASN C OD1 1 
ATOM   4439 N ND2 . ASN C 3 105 ? 207.914 280.700 364.095 1.00 18.51 ? 105 ASN C ND2 1 
ATOM   4440 N N   . TYR C 3 106 ? 212.235 282.244 360.952 1.00 14.38 ? 106 TYR C N   1 
ATOM   4441 C CA  . TYR C 3 106 ? 213.410 282.923 360.427 1.00 15.33 ? 106 TYR C CA  1 
ATOM   4442 C C   . TYR C 3 106 ? 213.126 283.663 359.129 1.00 11.36 ? 106 TYR C C   1 
ATOM   4443 O O   . TYR C 3 106 ? 214.055 284.202 358.525 1.00 9.99  ? 106 TYR C O   1 
ATOM   4444 C CB  . TYR C 3 106 ? 214.551 281.923 360.210 1.00 11.89 ? 106 TYR C CB  1 
ATOM   4445 C CG  . TYR C 3 106 ? 215.318 281.616 361.468 1.00 16.35 ? 106 TYR C CG  1 
ATOM   4446 C CD1 . TYR C 3 106 ? 216.203 282.540 362.001 1.00 8.29  ? 106 TYR C CD1 1 
ATOM   4447 C CD2 . TYR C 3 106 ? 215.158 280.405 362.128 1.00 13.51 ? 106 TYR C CD2 1 
ATOM   4448 C CE1 . TYR C 3 106 ? 216.901 282.273 363.150 1.00 5.00  ? 106 TYR C CE1 1 
ATOM   4449 C CE2 . TYR C 3 106 ? 215.857 280.128 363.280 1.00 9.48  ? 106 TYR C CE2 1 
ATOM   4450 C CZ  . TYR C 3 106 ? 216.727 281.066 363.787 1.00 14.16 ? 106 TYR C CZ  1 
ATOM   4451 O OH  . TYR C 3 106 ? 217.431 280.800 364.936 1.00 18.80 ? 106 TYR C OH  1 
ATOM   4452 N N   . TYR C 3 107 ? 211.874 283.706 358.690 1.00 9.92  ? 107 TYR C N   1 
ATOM   4453 C CA  . TYR C 3 107 ? 211.503 284.357 357.446 1.00 12.63 ? 107 TYR C CA  1 
ATOM   4454 C C   . TYR C 3 107 ? 210.247 285.183 357.659 1.00 4.52  ? 107 TYR C C   1 
ATOM   4455 O O   . TYR C 3 107 ? 209.535 285.034 358.653 1.00 15.52 ? 107 TYR C O   1 
ATOM   4456 C CB  . TYR C 3 107 ? 211.303 283.334 356.324 1.00 7.29  ? 107 TYR C CB  1 
ATOM   4457 C CG  . TYR C 3 107 ? 212.603 282.740 355.859 1.00 8.15  ? 107 TYR C CG  1 
ATOM   4458 C CD1 . TYR C 3 107 ? 213.135 281.611 356.475 1.00 14.65 ? 107 TYR C CD1 1 
ATOM   4459 C CD2 . TYR C 3 107 ? 213.319 283.322 354.826 1.00 3.42  ? 107 TYR C CD2 1 
ATOM   4460 C CE1 . TYR C 3 107 ? 214.332 281.073 356.061 1.00 5.79  ? 107 TYR C CE1 1 
ATOM   4461 C CE2 . TYR C 3 107 ? 214.515 282.789 354.404 1.00 8.62  ? 107 TYR C CE2 1 
ATOM   4462 C CZ  . TYR C 3 107 ? 215.019 281.666 355.027 1.00 12.45 ? 107 TYR C CZ  1 
ATOM   4463 O OH  . TYR C 3 107 ? 216.212 281.133 354.610 1.00 9.14  ? 107 TYR C OH  1 
ATOM   4464 N N   . THR C 3 108 ? 209.998 286.082 356.715 1.00 11.67 ? 108 THR C N   1 
ATOM   4465 C CA  . THR C 3 108 ? 208.876 287.004 356.792 1.00 8.52  ? 108 THR C CA  1 
ATOM   4466 C C   . THR C 3 108 ? 207.689 286.576 355.950 1.00 6.44  ? 108 THR C C   1 
ATOM   4467 O O   . THR C 3 108 ? 206.552 286.795 356.362 1.00 4.38  ? 108 THR C O   1 
ATOM   4468 C CB  . THR C 3 108 ? 209.315 288.408 356.353 1.00 7.23  ? 108 THR C CB  1 
ATOM   4469 O OG1 . THR C 3 108 ? 210.560 288.737 356.979 1.00 16.26 ? 108 THR C OG1 1 
ATOM   4470 C CG2 . THR C 3 108 ? 208.281 289.452 356.733 1.00 4.44  ? 108 THR C CG2 1 
ATOM   4471 N N   . HIS C 3 109 ? 207.920 285.950 354.800 1.00 9.41  ? 109 HIS C N   1 
ATOM   4472 C CA  . HIS C 3 109 ? 206.847 285.554 353.899 1.00 5.90  ? 109 HIS C CA  1 
ATOM   4473 C C   . HIS C 3 109 ? 206.890 284.048 353.697 1.00 7.08  ? 109 HIS C C   1 
ATOM   4474 O O   . HIS C 3 109 ? 207.973 283.470 353.600 1.00 9.30  ? 109 HIS C O   1 
ATOM   4475 C CB  . HIS C 3 109 ? 206.972 286.267 352.551 1.00 10.34 ? 109 HIS C CB  1 
ATOM   4476 C CG  . HIS C 3 109 ? 207.055 287.757 352.657 1.00 7.04  ? 109 HIS C CG  1 
ATOM   4477 N ND1 . HIS C 3 109 ? 207.748 288.527 351.751 1.00 8.26  ? 109 HIS C ND1 1 
ATOM   4478 C CD2 . HIS C 3 109 ? 206.531 288.618 353.558 1.00 8.00  ? 109 HIS C CD2 1 
ATOM   4479 C CE1 . HIS C 3 109 ? 207.651 289.798 352.090 1.00 7.47  ? 109 HIS C CE1 1 
ATOM   4480 N NE2 . HIS C 3 109 ? 206.919 289.880 353.186 1.00 12.50 ? 109 HIS C NE2 1 
ATOM   4481 N N   . TRP C 3 110 ? 205.719 283.416 353.627 1.00 14.82 ? 110 TRP C N   1 
ATOM   4482 C CA  . TRP C 3 110 ? 205.626 281.997 353.317 1.00 8.13  ? 110 TRP C CA  1 
ATOM   4483 C C   . TRP C 3 110 ? 204.483 281.747 352.346 1.00 12.78 ? 110 TRP C C   1 
ATOM   4484 O O   . TRP C 3 110 ? 203.479 282.461 352.343 1.00 12.32 ? 110 TRP C O   1 
ATOM   4485 C CB  . TRP C 3 110 ? 205.427 281.143 354.582 1.00 10.22 ? 110 TRP C CB  1 
ATOM   4486 C CG  . TRP C 3 110 ? 204.048 281.198 355.181 1.00 8.86  ? 110 TRP C CG  1 
ATOM   4487 C CD1 . TRP C 3 110 ? 203.594 282.086 356.107 1.00 11.11 ? 110 TRP C CD1 1 
ATOM   4488 C CD2 . TRP C 3 110 ? 202.952 280.316 354.903 1.00 13.69 ? 110 TRP C CD2 1 
ATOM   4489 N NE1 . TRP C 3 110 ? 202.288 281.818 356.422 1.00 7.30  ? 110 TRP C NE1 1 
ATOM   4490 C CE2 . TRP C 3 110 ? 201.869 280.736 355.695 1.00 14.66 ? 110 TRP C CE2 1 
ATOM   4491 C CE3 . TRP C 3 110 ? 202.782 279.216 354.058 1.00 9.08  ? 110 TRP C CE3 1 
ATOM   4492 C CZ2 . TRP C 3 110 ? 200.635 280.092 355.671 1.00 11.05 ? 110 TRP C CZ2 1 
ATOM   4493 C CZ3 . TRP C 3 110 ? 201.561 278.580 354.037 1.00 6.44  ? 110 TRP C CZ3 1 
ATOM   4494 C CH2 . TRP C 3 110 ? 200.502 279.021 354.837 1.00 6.84  ? 110 TRP C CH2 1 
ATOM   4495 N N   . ALA C 3 111 ? 204.653 280.724 351.513 1.00 14.51 ? 111 ALA C N   1 
ATOM   4496 C CA  . ALA C 3 111 ? 203.592 280.261 350.632 1.00 9.98  ? 111 ALA C CA  1 
ATOM   4497 C C   . ALA C 3 111 ? 203.757 278.768 350.396 1.00 12.44 ? 111 ALA C C   1 
ATOM   4498 O O   . ALA C 3 111 ? 204.860 278.232 350.497 1.00 17.12 ? 111 ALA C O   1 
ATOM   4499 C CB  . ALA C 3 111 ? 203.596 281.010 349.295 1.00 7.31  ? 111 ALA C CB  1 
ATOM   4500 N N   . GLY C 3 112 ? 202.653 278.102 350.080 1.00 9.12  ? 112 GLY C N   1 
ATOM   4501 C CA  . GLY C 3 112 ? 202.663 276.695 349.736 1.00 8.77  ? 112 GLY C CA  1 
ATOM   4502 C C   . GLY C 3 112 ? 201.680 275.891 350.565 1.00 12.05 ? 112 GLY C C   1 
ATOM   4503 O O   . GLY C 3 112 ? 201.102 276.363 351.541 1.00 16.35 ? 112 GLY C O   1 
ATOM   4504 N N   . SER C 3 113 ? 201.512 274.639 350.146 1.00 18.17 ? 113 SER C N   1 
ATOM   4505 C CA  . SER C 3 113 ? 200.587 273.717 350.790 1.00 14.11 ? 113 SER C CA  1 
ATOM   4506 C C   . SER C 3 113 ? 201.184 273.147 352.070 1.00 12.29 ? 113 SER C C   1 
ATOM   4507 O O   . SER C 3 113 ? 202.400 273.155 352.271 1.00 17.89 ? 113 SER C O   1 
ATOM   4508 C CB  . SER C 3 113 ? 200.234 272.568 349.847 1.00 12.27 ? 113 SER C CB  1 
ATOM   4509 O OG  . SER C 3 113 ? 199.736 273.051 348.616 1.00 16.70 ? 113 SER C OG  1 
ATOM   4510 N N   . LEU C 3 114 ? 200.313 272.639 352.936 1.00 10.27 ? 114 LEU C N   1 
ATOM   4511 C CA  . LEU C 3 114 ? 200.732 271.989 354.168 1.00 19.00 ? 114 LEU C CA  1 
ATOM   4512 C C   . LEU C 3 114 ? 200.199 270.566 354.208 1.00 16.85 ? 114 LEU C C   1 
ATOM   4513 O O   . LEU C 3 114 ? 199.254 270.219 353.500 1.00 21.44 ? 114 LEU C O   1 
ATOM   4514 C CB  . LEU C 3 114 ? 200.250 272.747 355.410 1.00 19.86 ? 114 LEU C CB  1 
ATOM   4515 C CG  . LEU C 3 114 ? 200.938 274.071 355.745 1.00 19.33 ? 114 LEU C CG  1 
ATOM   4516 C CD1 . LEU C 3 114 ? 200.464 274.569 357.095 1.00 18.93 ? 114 LEU C CD1 1 
ATOM   4517 C CD2 . LEU C 3 114 ? 202.447 273.934 355.736 1.00 18.29 ? 114 LEU C CD2 1 
ATOM   4518 N N   . LYS C 3 115 ? 200.818 269.745 355.044 1.00 22.20 ? 115 LYS C N   1 
ATOM   4519 C CA  . LYS C 3 115 ? 200.440 268.354 355.219 1.00 16.28 ? 115 LYS C CA  1 
ATOM   4520 C C   . LYS C 3 115 ? 200.232 268.103 356.703 1.00 11.08 ? 115 LYS C C   1 
ATOM   4521 O O   . LYS C 3 115 ? 201.139 268.354 357.504 1.00 11.45 ? 115 LYS C O   1 
ATOM   4522 C CB  . LYS C 3 115 ? 201.531 267.436 354.663 1.00 18.52 ? 115 LYS C CB  1 
ATOM   4523 C CG  . LYS C 3 115 ? 201.028 266.219 353.922 1.00 21.63 ? 115 LYS C CG  1 
ATOM   4524 C CD  . LYS C 3 115 ? 201.910 265.897 352.723 1.00 21.64 ? 115 LYS C CD  1 
ATOM   4525 C CE  . LYS C 3 115 ? 203.341 265.565 353.126 1.00 20.70 ? 115 LYS C CE  1 
ATOM   4526 N NZ  . LYS C 3 115 ? 203.419 264.335 353.960 1.00 24.64 ? 115 LYS C NZ  1 
ATOM   4527 N N   . PHE C 3 116 ? 199.043 267.628 357.069 1.00 15.63 ? 116 PHE C N   1 
ATOM   4528 C CA  . PHE C 3 116 ? 198.736 267.251 358.442 1.00 14.94 ? 116 PHE C CA  1 
ATOM   4529 C C   . PHE C 3 116 ? 198.484 265.753 358.483 1.00 13.52 ? 116 PHE C C   1 
ATOM   4530 O O   . PHE C 3 116 ? 197.558 265.260 357.836 1.00 23.43 ? 116 PHE C O   1 
ATOM   4531 C CB  . PHE C 3 116 ? 197.519 268.011 358.974 1.00 11.46 ? 116 PHE C CB  1 
ATOM   4532 C CG  . PHE C 3 116 ? 197.778 269.460 359.251 1.00 15.01 ? 116 PHE C CG  1 
ATOM   4533 C CD1 . PHE C 3 116 ? 197.690 270.400 358.240 1.00 12.86 ? 116 PHE C CD1 1 
ATOM   4534 C CD2 . PHE C 3 116 ? 198.108 269.886 360.523 1.00 15.39 ? 116 PHE C CD2 1 
ATOM   4535 C CE1 . PHE C 3 116 ? 197.928 271.731 358.494 1.00 17.22 ? 116 PHE C CE1 1 
ATOM   4536 C CE2 . PHE C 3 116 ? 198.346 271.219 360.781 1.00 14.94 ? 116 PHE C CE2 1 
ATOM   4537 C CZ  . PHE C 3 116 ? 198.256 272.141 359.767 1.00 14.50 ? 116 PHE C CZ  1 
ATOM   4538 N N   . THR C 3 117 ? 199.296 265.037 359.245 1.00 16.03 ? 117 THR C N   1 
ATOM   4539 C CA  . THR C 3 117 ? 199.126 263.609 359.447 1.00 17.72 ? 117 THR C CA  1 
ATOM   4540 C C   . THR C 3 117 ? 198.639 263.368 360.865 1.00 16.67 ? 117 THR C C   1 
ATOM   4541 O O   . THR C 3 117 ? 199.097 264.015 361.807 1.00 20.27 ? 117 THR C O   1 
ATOM   4542 C CB  . THR C 3 117 ? 200.432 262.848 359.200 1.00 22.33 ? 117 THR C CB  1 
ATOM   4543 O OG1 . THR C 3 117 ? 200.811 262.977 357.826 1.00 23.67 ? 117 THR C OG1 1 
ATOM   4544 C CG2 . THR C 3 117 ? 200.271 261.374 359.541 1.00 21.12 ? 117 THR C CG2 1 
ATOM   4545 N N   . PHE C 3 118 ? 197.688 262.460 361.011 1.00 19.66 ? 118 PHE C N   1 
ATOM   4546 C CA  . PHE C 3 118 ? 197.164 262.088 362.313 1.00 15.58 ? 118 PHE C CA  1 
ATOM   4547 C C   . PHE C 3 118 ? 197.323 260.591 362.501 1.00 9.98  ? 118 PHE C C   1 
ATOM   4548 O O   . PHE C 3 118 ? 196.971 259.806 361.617 1.00 17.89 ? 118 PHE C O   1 
ATOM   4549 C CB  . PHE C 3 118 ? 195.703 262.502 362.457 1.00 16.05 ? 118 PHE C CB  1 
ATOM   4550 C CG  . PHE C 3 118 ? 195.513 263.980 362.584 1.00 18.21 ? 118 PHE C CG  1 
ATOM   4551 C CD1 . PHE C 3 118 ? 195.662 264.604 363.808 1.00 16.31 ? 118 PHE C CD1 1 
ATOM   4552 C CD2 . PHE C 3 118 ? 195.202 264.750 361.477 1.00 19.73 ? 118 PHE C CD2 1 
ATOM   4553 C CE1 . PHE C 3 118 ? 195.495 265.964 363.927 1.00 17.31 ? 118 PHE C CE1 1 
ATOM   4554 C CE2 . PHE C 3 118 ? 195.033 266.110 361.593 1.00 16.39 ? 118 PHE C CE2 1 
ATOM   4555 C CZ  . PHE C 3 118 ? 195.180 266.718 362.817 1.00 19.87 ? 118 PHE C CZ  1 
ATOM   4556 N N   . LEU C 3 119 ? 197.872 260.211 363.651 1.00 16.43 ? 119 LEU C N   1 
ATOM   4557 C CA  . LEU C 3 119 ? 198.159 258.825 363.986 1.00 16.67 ? 119 LEU C CA  1 
ATOM   4558 C C   . LEU C 3 119 ? 197.293 258.409 365.164 1.00 12.51 ? 119 LEU C C   1 
ATOM   4559 O O   . LEU C 3 119 ? 197.312 259.062 366.212 1.00 16.41 ? 119 LEU C O   1 
ATOM   4560 C CB  . LEU C 3 119 ? 199.641 258.637 364.324 1.00 15.38 ? 119 LEU C CB  1 
ATOM   4561 C CG  . LEU C 3 119 ? 200.113 257.214 364.628 1.00 19.02 ? 119 LEU C CG  1 
ATOM   4562 C CD1 . LEU C 3 119 ? 199.989 256.323 363.405 1.00 14.02 ? 119 LEU C CD1 1 
ATOM   4563 C CD2 . LEU C 3 119 ? 201.545 257.231 365.134 1.00 19.09 ? 119 LEU C CD2 1 
ATOM   4564 N N   . PHE C 3 120 ? 196.548 257.322 364.986 1.00 12.00 ? 120 PHE C N   1 
ATOM   4565 C CA  . PHE C 3 120 ? 195.670 256.790 366.017 1.00 18.16 ? 120 PHE C CA  1 
ATOM   4566 C C   . PHE C 3 120 ? 196.405 255.709 366.797 1.00 18.06 ? 120 PHE C C   1 
ATOM   4567 O O   . PHE C 3 120 ? 196.948 254.770 366.208 1.00 15.30 ? 120 PHE C O   1 
ATOM   4568 C CB  . PHE C 3 120 ? 194.392 256.233 365.385 1.00 18.53 ? 120 PHE C CB  1 
ATOM   4569 C CG  . PHE C 3 120 ? 193.485 255.538 366.353 1.00 15.76 ? 120 PHE C CG  1 
ATOM   4570 C CD1 . PHE C 3 120 ? 192.586 256.255 367.117 1.00 20.46 ? 120 PHE C CD1 1 
ATOM   4571 C CD2 . PHE C 3 120 ? 193.522 254.162 366.488 1.00 12.77 ? 120 PHE C CD2 1 
ATOM   4572 C CE1 . PHE C 3 120 ? 191.748 255.617 368.003 1.00 17.94 ? 120 PHE C CE1 1 
ATOM   4573 C CE2 . PHE C 3 120 ? 192.687 253.520 367.373 1.00 14.65 ? 120 PHE C CE2 1 
ATOM   4574 C CZ  . PHE C 3 120 ? 191.801 254.246 368.133 1.00 18.53 ? 120 PHE C CZ  1 
ATOM   4575 N N   . CYS C 3 121 ? 196.422 255.844 368.118 1.00 13.75 ? 121 CYS C N   1 
ATOM   4576 C CA  . CYS C 3 121 ? 197.241 255.010 368.987 1.00 14.17 ? 121 CYS C CA  1 
ATOM   4577 C C   . CYS C 3 121 ? 196.391 254.283 370.021 1.00 18.13 ? 121 CYS C C   1 
ATOM   4578 O O   . CYS C 3 121 ? 196.739 254.215 371.201 1.00 20.29 ? 121 CYS C O   1 
ATOM   4579 C CB  . CYS C 3 121 ? 198.320 255.846 369.672 1.00 17.35 ? 121 CYS C CB  1 
ATOM   4580 S SG  . CYS C 3 121 ? 199.440 256.682 368.534 1.00 18.87 ? 121 CYS C SG  1 
ATOM   4581 N N   . GLY C 3 122 ? 195.257 253.735 369.585 1.00 19.35 ? 122 GLY C N   1 
ATOM   4582 C CA  . GLY C 3 122 ? 194.450 252.863 370.405 1.00 18.13 ? 122 GLY C CA  1 
ATOM   4583 C C   . GLY C 3 122 ? 194.739 251.399 370.124 1.00 17.85 ? 122 GLY C C   1 
ATOM   4584 O O   . GLY C 3 122 ? 195.701 251.039 369.445 1.00 26.59 ? 122 GLY C O   1 
ATOM   4585 N N   . SER C 3 123 ? 193.877 250.542 370.658 1.00 17.84 ? 123 SER C N   1 
ATOM   4586 C CA  . SER C 3 123 ? 194.035 249.113 370.443 1.00 16.10 ? 123 SER C CA  1 
ATOM   4587 C C   . SER C 3 123 ? 193.623 248.734 369.025 1.00 17.01 ? 123 SER C C   1 
ATOM   4588 O O   . SER C 3 123 ? 192.938 249.482 368.323 1.00 24.27 ? 123 SER C O   1 
ATOM   4589 C CB  . SER C 3 123 ? 193.210 248.321 371.453 1.00 13.79 ? 123 SER C CB  1 
ATOM   4590 O OG  . SER C 3 123 ? 191.825 248.457 371.196 1.00 25.20 ? 123 SER C OG  1 
ATOM   4591 N N   . MET C 3 124 ? 194.063 247.550 368.601 1.00 27.11 ? 124 MET C N   1 
ATOM   4592 C CA  . MET C 3 124 ? 193.669 247.032 367.298 1.00 24.19 ? 124 MET C CA  1 
ATOM   4593 C C   . MET C 3 124 ? 192.184 246.703 367.240 1.00 25.42 ? 124 MET C C   1 
ATOM   4594 O O   . MET C 3 124 ? 191.627 246.599 366.144 1.00 27.15 ? 124 MET C O   1 
ATOM   4595 C CB  . MET C 3 124 ? 194.491 245.789 366.961 1.00 26.02 ? 124 MET C CB  1 
ATOM   4596 C CG  . MET C 3 124 ? 194.416 245.371 365.507 1.00 27.50 ? 124 MET C CG  1 
ATOM   4597 S SD  . MET C 3 124 ? 195.405 243.911 365.142 1.00 55.65 ? 124 MET C SD  1 
ATOM   4598 C CE  . MET C 3 124 ? 195.182 243.780 363.371 1.00 31.09 ? 124 MET C CE  1 
ATOM   4599 N N   . MET C 3 125 ? 191.533 246.546 368.390 1.00 19.13 ? 125 MET C N   1 
ATOM   4600 C CA  . MET C 3 125 ? 190.115 246.226 368.456 1.00 18.86 ? 125 MET C CA  1 
ATOM   4601 C C   . MET C 3 125 ? 189.219 247.451 368.339 1.00 18.73 ? 125 MET C C   1 
ATOM   4602 O O   . MET C 3 125 ? 187.995 247.302 368.355 1.00 25.08 ? 125 MET C O   1 
ATOM   4603 C CB  . MET C 3 125 ? 189.809 245.499 369.767 1.00 24.52 ? 125 MET C CB  1 
ATOM   4604 C CG  . MET C 3 125 ? 190.330 244.076 369.825 1.00 17.63 ? 125 MET C CG  1 
ATOM   4605 S SD  . MET C 3 125 ? 189.339 242.944 368.838 1.00 36.82 ? 125 MET C SD  1 
ATOM   4606 C CE  . MET C 3 125 ? 190.591 242.212 367.799 1.00 24.08 ? 125 MET C CE  1 
ATOM   4607 N N   . ALA C 3 126 ? 189.787 248.646 368.224 1.00 23.38 ? 126 ALA C N   1 
ATOM   4608 C CA  . ALA C 3 126 ? 189.004 249.870 368.154 1.00 18.68 ? 126 ALA C CA  1 
ATOM   4609 C C   . ALA C 3 126 ? 188.637 250.189 366.712 1.00 15.26 ? 126 ALA C C   1 
ATOM   4610 O O   . ALA C 3 126 ? 189.421 249.955 365.789 1.00 20.01 ? 126 ALA C O   1 
ATOM   4611 C CB  . ALA C 3 126 ? 189.777 251.035 368.769 1.00 18.04 ? 126 ALA C CB  1 
ATOM   4612 N N   . THR C 3 127 ? 187.431 250.717 366.526 1.00 20.15 ? 127 THR C N   1 
ATOM   4613 C CA  . THR C 3 127 ? 186.942 251.138 365.224 1.00 18.41 ? 127 THR C CA  1 
ATOM   4614 C C   . THR C 3 127 ? 186.336 252.526 365.360 1.00 18.88 ? 127 THR C C   1 
ATOM   4615 O O   . THR C 3 127 ? 186.005 252.975 366.459 1.00 21.75 ? 127 THR C O   1 
ATOM   4616 C CB  . THR C 3 127 ? 185.894 250.161 364.649 1.00 20.74 ? 127 THR C CB  1 
ATOM   4617 O OG1 . THR C 3 127 ? 184.736 250.131 365.492 1.00 18.06 ? 127 THR C OG1 1 
ATOM   4618 C CG2 . THR C 3 127 ? 186.464 248.758 364.530 1.00 18.78 ? 127 THR C CG2 1 
ATOM   4619 N N   . GLY C 3 128 ? 186.207 253.207 364.236 1.00 16.44 ? 128 GLY C N   1 
ATOM   4620 C CA  . GLY C 3 128 ? 185.609 254.523 364.222 1.00 17.92 ? 128 GLY C CA  1 
ATOM   4621 C C   . GLY C 3 128 ? 185.983 255.286 362.977 1.00 14.35 ? 128 GLY C C   1 
ATOM   4622 O O   . GLY C 3 128 ? 186.969 254.995 362.301 1.00 16.88 ? 128 GLY C O   1 
ATOM   4623 N N   . LYS C 3 129 ? 185.167 256.287 362.671 1.00 20.35 ? 129 LYS C N   1 
ATOM   4624 C CA  . LYS C 3 129 ? 185.393 257.171 361.537 1.00 18.29 ? 129 LYS C CA  1 
ATOM   4625 C C   . LYS C 3 129 ? 185.417 258.608 362.027 1.00 13.72 ? 129 LYS C C   1 
ATOM   4626 O O   . LYS C 3 129 ? 184.565 259.014 362.823 1.00 15.88 ? 129 LYS C O   1 
ATOM   4627 C CB  . LYS C 3 129 ? 184.320 256.987 360.464 1.00 17.16 ? 129 LYS C CB  1 
ATOM   4628 C CG  . LYS C 3 129 ? 184.373 255.636 359.780 1.00 18.82 ? 129 LYS C CG  1 
ATOM   4629 C CD  . LYS C 3 129 ? 183.250 255.481 358.777 1.00 21.22 ? 129 LYS C CD  1 
ATOM   4630 C CE  . LYS C 3 129 ? 183.011 254.024 358.421 1.00 22.90 ? 129 LYS C CE  1 
ATOM   4631 N NZ  . LYS C 3 129 ? 184.206 253.395 357.804 1.00 26.98 ? 129 LYS C NZ  1 
ATOM   4632 N N   . LEU C 3 130 ? 186.396 259.365 361.550 1.00 16.78 ? 130 LEU C N   1 
ATOM   4633 C CA  . LEU C 3 130 ? 186.594 260.754 361.928 1.00 20.20 ? 130 LEU C CA  1 
ATOM   4634 C C   . LEU C 3 130 ? 186.583 261.622 360.681 1.00 14.67 ? 130 LEU C C   1 
ATOM   4635 O O   . LEU C 3 130 ? 186.871 261.154 359.581 1.00 14.81 ? 130 LEU C O   1 
ATOM   4636 C CB  . LEU C 3 130 ? 187.915 260.935 362.684 1.00 18.48 ? 130 LEU C CB  1 
ATOM   4637 C CG  . LEU C 3 130 ? 188.042 260.104 363.960 1.00 18.19 ? 130 LEU C CG  1 
ATOM   4638 C CD1 . LEU C 3 130 ? 189.422 260.252 364.563 1.00 20.94 ? 130 LEU C CD1 1 
ATOM   4639 C CD2 . LEU C 3 130 ? 186.975 260.499 364.961 1.00 18.45 ? 130 LEU C CD2 1 
ATOM   4640 N N   . LEU C 3 131 ? 186.228 262.890 360.856 1.00 19.96 ? 131 LEU C N   1 
ATOM   4641 C CA  . LEU C 3 131 ? 186.182 263.854 359.765 1.00 16.07 ? 131 LEU C CA  1 
ATOM   4642 C C   . LEU C 3 131 ? 187.200 264.947 360.048 1.00 15.35 ? 131 LEU C C   1 
ATOM   4643 O O   . LEU C 3 131 ? 187.159 265.575 361.110 1.00 22.55 ? 131 LEU C O   1 
ATOM   4644 C CB  . LEU C 3 131 ? 184.773 264.437 359.615 1.00 19.76 ? 131 LEU C CB  1 
ATOM   4645 C CG  . LEU C 3 131 ? 184.522 265.359 358.419 1.00 17.22 ? 131 LEU C CG  1 
ATOM   4646 C CD1 . LEU C 3 131 ? 183.083 265.242 357.966 1.00 23.01 ? 131 LEU C CD1 1 
ATOM   4647 C CD2 . LEU C 3 131 ? 184.845 266.802 358.756 1.00 19.90 ? 131 LEU C CD2 1 
ATOM   4648 N N   . VAL C 3 132 ? 188.109 265.173 359.104 1.00 16.95 ? 132 VAL C N   1 
ATOM   4649 C CA  . VAL C 3 132 ? 189.143 266.196 359.233 1.00 13.93 ? 132 VAL C CA  1 
ATOM   4650 C C   . VAL C 3 132 ? 188.894 267.233 358.150 1.00 14.99 ? 132 VAL C C   1 
ATOM   4651 O O   . VAL C 3 132 ? 188.861 266.893 356.963 1.00 17.33 ? 132 VAL C O   1 
ATOM   4652 C CB  . VAL C 3 132 ? 190.555 265.598 359.116 1.00 17.25 ? 132 VAL C CB  1 
ATOM   4653 C CG1 . VAL C 3 132 ? 191.611 266.658 359.373 1.00 14.70 ? 132 VAL C CG1 1 
ATOM   4654 C CG2 . VAL C 3 132 ? 190.716 264.444 360.083 1.00 21.52 ? 132 VAL C CG2 1 
ATOM   4655 N N   . SER C 3 133 ? 188.730 268.494 358.549 1.00 15.84 ? 133 SER C N   1 
ATOM   4656 C CA  . SER C 3 133 ? 188.281 269.533 357.631 1.00 22.15 ? 133 SER C CA  1 
ATOM   4657 C C   . SER C 3 133 ? 189.183 270.758 357.676 1.00 16.09 ? 133 SER C C   1 
ATOM   4658 O O   . SER C 3 133 ? 189.665 271.154 358.740 1.00 13.15 ? 133 SER C O   1 
ATOM   4659 C CB  . SER C 3 133 ? 186.843 269.955 357.948 1.00 20.08 ? 133 SER C CB  1 
ATOM   4660 O OG  . SER C 3 133 ? 186.733 270.412 359.282 1.00 26.57 ? 133 SER C OG  1 
ATOM   4661 N N   . TYR C 3 134 ? 189.391 271.352 356.505 1.00 19.52 ? 134 TYR C N   1 
ATOM   4662 C CA  . TYR C 3 134 ? 189.984 272.672 356.350 1.00 15.67 ? 134 TYR C CA  1 
ATOM   4663 C C   . TYR C 3 134 ? 188.943 273.615 355.762 1.00 13.09 ? 134 TYR C C   1 
ATOM   4664 O O   . TYR C 3 134 ? 188.359 273.328 354.708 1.00 19.49 ? 134 TYR C O   1 
ATOM   4665 C CB  . TYR C 3 134 ? 191.221 272.628 355.452 1.00 16.99 ? 134 TYR C CB  1 
ATOM   4666 C CG  . TYR C 3 134 ? 191.705 274.001 355.059 1.00 14.20 ? 134 TYR C CG  1 
ATOM   4667 C CD1 . TYR C 3 134 ? 192.151 274.900 356.018 1.00 18.47 ? 134 TYR C CD1 1 
ATOM   4668 C CD2 . TYR C 3 134 ? 191.703 274.405 353.735 1.00 17.24 ? 134 TYR C CD2 1 
ATOM   4669 C CE1 . TYR C 3 134 ? 192.584 276.154 355.668 1.00 19.05 ? 134 TYR C CE1 1 
ATOM   4670 C CE2 . TYR C 3 134 ? 192.136 275.660 353.375 1.00 10.40 ? 134 TYR C CE2 1 
ATOM   4671 C CZ  . TYR C 3 134 ? 192.577 276.530 354.345 1.00 15.29 ? 134 TYR C CZ  1 
ATOM   4672 O OH  . TYR C 3 134 ? 193.011 277.781 353.992 1.00 14.56 ? 134 TYR C OH  1 
ATOM   4673 N N   . ALA C 3 135 ? 188.714 274.733 356.451 1.00 15.32 ? 135 ALA C N   1 
ATOM   4674 C CA  . ALA C 3 135 ? 187.861 275.804 355.964 1.00 13.58 ? 135 ALA C CA  1 
ATOM   4675 C C   . ALA C 3 135 ? 188.718 277.006 355.605 1.00 13.76 ? 135 ALA C C   1 
ATOM   4676 O O   . ALA C 3 135 ? 189.396 277.548 356.493 1.00 18.17 ? 135 ALA C O   1 
ATOM   4677 C CB  . ALA C 3 135 ? 186.835 276.195 357.020 1.00 9.89  ? 135 ALA C CB  1 
ATOM   4678 N N   . PRO C 3 136 ? 188.737 277.458 354.354 1.00 18.89 ? 136 PRO C N   1 
ATOM   4679 C CA  . PRO C 3 136 ? 189.445 278.698 354.030 1.00 17.58 ? 136 PRO C CA  1 
ATOM   4680 C C   . PRO C 3 136 ? 188.883 279.862 354.824 1.00 16.20 ? 136 PRO C C   1 
ATOM   4681 O O   . PRO C 3 136 ? 187.755 279.791 355.333 1.00 19.40 ? 136 PRO C O   1 
ATOM   4682 C CB  . PRO C 3 136 ? 189.193 278.869 352.525 1.00 13.38 ? 136 PRO C CB  1 
ATOM   4683 C CG  . PRO C 3 136 ? 188.929 277.503 352.033 1.00 17.44 ? 136 PRO C CG  1 
ATOM   4684 C CD  . PRO C 3 136 ? 188.223 276.792 353.145 1.00 13.70 ? 136 PRO C CD  1 
ATOM   4685 N N   . PRO C 3 137 ? 189.634 280.947 354.960 1.00 15.36 ? 137 PRO C N   1 
ATOM   4686 C CA  . PRO C 3 137 ? 189.215 282.033 355.850 1.00 15.99 ? 137 PRO C CA  1 
ATOM   4687 C C   . PRO C 3 137 ? 188.116 282.891 355.233 1.00 17.05 ? 137 PRO C C   1 
ATOM   4688 O O   . PRO C 3 137 ? 187.833 282.839 354.038 1.00 21.21 ? 137 PRO C O   1 
ATOM   4689 C CB  . PRO C 3 137 ? 190.502 282.831 356.054 1.00 13.59 ? 137 PRO C CB  1 
ATOM   4690 C CG  . PRO C 3 137 ? 191.312 282.570 354.846 1.00 10.28 ? 137 PRO C CG  1 
ATOM   4691 C CD  . PRO C 3 137 ? 190.912 281.238 354.289 1.00 10.19 ? 137 PRO C CD  1 
ATOM   4692 N N   . GLY C 3 138 ? 187.483 283.682 356.094 1.00 18.95 ? 138 GLY C N   1 
ATOM   4693 C CA  . GLY C 3 138 ? 186.459 284.610 355.660 1.00 14.15 ? 138 GLY C CA  1 
ATOM   4694 C C   . GLY C 3 138 ? 185.160 284.482 356.425 1.00 17.93 ? 138 GLY C C   1 
ATOM   4695 O O   . GLY C 3 138 ? 184.482 285.481 356.674 1.00 26.86 ? 138 GLY C O   1 
ATOM   4696 N N   . ALA C 3 139 ? 184.798 283.263 356.799 1.00 28.04 ? 139 ALA C N   1 
ATOM   4697 C CA  . ALA C 3 139 ? 183.574 282.993 357.535 1.00 20.48 ? 139 ALA C CA  1 
ATOM   4698 C C   . ALA C 3 139 ? 183.900 282.698 358.992 1.00 25.67 ? 139 ALA C C   1 
ATOM   4699 O O   . ALA C 3 139 ? 185.062 282.571 359.385 1.00 26.32 ? 139 ALA C O   1 
ATOM   4700 C CB  . ALA C 3 139 ? 182.809 281.823 356.909 1.00 14.03 ? 139 ALA C CB  1 
ATOM   4701 N N   . GLU C 3 140 ? 182.849 282.594 359.796 1.00 29.19 ? 140 GLU C N   1 
ATOM   4702 C CA  . GLU C 3 140 ? 183.019 282.230 361.193 1.00 26.35 ? 140 GLU C CA  1 
ATOM   4703 C C   . GLU C 3 140 ? 183.622 280.834 361.292 1.00 28.60 ? 140 GLU C C   1 
ATOM   4704 O O   . GLU C 3 140 ? 183.359 279.960 360.464 1.00 29.65 ? 140 GLU C O   1 
ATOM   4705 C CB  . GLU C 3 140 ? 181.677 282.285 361.919 1.00 27.07 ? 140 GLU C CB  1 
ATOM   4706 C CG  . GLU C 3 140 ? 181.789 282.290 363.430 1.00 33.40 ? 140 GLU C CG  1 
ATOM   4707 C CD  . GLU C 3 140 ? 180.437 282.284 364.110 1.00 39.60 ? 140 GLU C CD  1 
ATOM   4708 O OE1 . GLU C 3 140 ? 179.423 282.066 363.415 1.00 37.03 ? 140 GLU C OE1 1 
ATOM   4709 O OE2 . GLU C 3 140 ? 180.386 282.497 365.340 1.00 39.58 ? 140 GLU C OE2 1 
ATOM   4710 N N   . ALA C 3 141 ? 184.455 280.633 362.305 1.00 27.13 ? 141 ALA C N   1 
ATOM   4711 C CA  . ALA C 3 141 ? 185.118 279.349 362.459 1.00 21.96 ? 141 ALA C CA  1 
ATOM   4712 C C   . ALA C 3 141 ? 184.082 278.260 362.737 1.00 28.70 ? 141 ALA C C   1 
ATOM   4713 O O   . ALA C 3 141 ? 183.211 278.436 363.593 1.00 32.54 ? 141 ALA C O   1 
ATOM   4714 C CB  . ALA C 3 141 ? 186.139 279.404 363.591 1.00 23.31 ? 141 ALA C CB  1 
ATOM   4715 N N   . PRO C 3 142 ? 184.147 277.127 362.036 1.00 24.69 ? 142 PRO C N   1 
ATOM   4716 C CA  . PRO C 3 142 ? 183.094 276.113 362.185 1.00 25.11 ? 142 PRO C CA  1 
ATOM   4717 C C   . PRO C 3 142 ? 183.075 275.529 363.589 1.00 27.16 ? 142 PRO C C   1 
ATOM   4718 O O   . PRO C 3 142 ? 184.109 275.131 364.128 1.00 27.53 ? 142 PRO C O   1 
ATOM   4719 C CB  . PRO C 3 142 ? 183.462 275.059 361.135 1.00 24.23 ? 142 PRO C CB  1 
ATOM   4720 C CG  . PRO C 3 142 ? 184.910 275.249 360.896 1.00 24.56 ? 142 PRO C CG  1 
ATOM   4721 C CD  . PRO C 3 142 ? 185.189 276.701 361.089 1.00 22.35 ? 142 PRO C CD  1 
ATOM   4722 N N   . LYS C 3 143 ? 181.882 275.469 364.173 1.00 30.86 ? 143 LYS C N   1 
ATOM   4723 C CA  . LYS C 3 143 ? 181.700 274.971 365.528 1.00 35.08 ? 143 LYS C CA  1 
ATOM   4724 C C   . LYS C 3 143 ? 180.934 273.658 365.577 1.00 29.70 ? 143 LYS C C   1 
ATOM   4725 O O   . LYS C 3 143 ? 180.690 273.141 366.671 1.00 30.67 ? 143 LYS C O   1 
ATOM   4726 C CB  . LYS C 3 143 ? 180.991 276.029 366.384 1.00 35.50 ? 143 LYS C CB  1 
ATOM   4727 C CG  . LYS C 3 143 ? 179.851 276.760 365.686 1.00 32.98 ? 143 LYS C CG  1 
ATOM   4728 C CD  . LYS C 3 143 ? 179.325 277.901 366.540 1.00 34.94 ? 143 LYS C CD  1 
ATOM   4729 C CE  . LYS C 3 143 ? 178.371 278.791 365.757 1.00 40.63 ? 143 LYS C CE  1 
ATOM   4730 N NZ  . LYS C 3 143 ? 177.141 278.070 365.323 1.00 38.52 ? 143 LYS C NZ  1 
ATOM   4731 N N   . SER C 3 144 ? 180.556 273.103 364.429 1.00 26.95 ? 144 SER C N   1 
ATOM   4732 C CA  . SER C 3 144 ? 179.882 271.817 364.380 1.00 28.02 ? 144 SER C CA  1 
ATOM   4733 C C   . SER C 3 144 ? 180.269 271.116 363.089 1.00 25.81 ? 144 SER C C   1 
ATOM   4734 O O   . SER C 3 144 ? 180.771 271.737 362.150 1.00 23.86 ? 144 SER C O   1 
ATOM   4735 C CB  . SER C 3 144 ? 178.359 271.964 364.468 1.00 25.76 ? 144 SER C CB  1 
ATOM   4736 O OG  . SER C 3 144 ? 177.835 272.568 363.302 1.00 29.88 ? 144 SER C OG  1 
ATOM   4737 N N   . ARG C 3 145 ? 180.032 269.804 363.057 1.00 25.00 ? 145 ARG C N   1 
ATOM   4738 C CA  . ARG C 3 145 ? 180.337 269.027 361.865 1.00 19.53 ? 145 ARG C CA  1 
ATOM   4739 C C   . ARG C 3 145 ? 179.539 269.495 360.656 1.00 23.94 ? 145 ARG C C   1 
ATOM   4740 O O   . ARG C 3 145 ? 180.008 269.340 359.524 1.00 28.56 ? 145 ARG C O   1 
ATOM   4741 C CB  . ARG C 3 145 ? 180.071 267.544 362.127 1.00 21.05 ? 145 ARG C CB  1 
ATOM   4742 C CG  . ARG C 3 145 ? 180.589 266.627 361.039 1.00 22.59 ? 145 ARG C CG  1 
ATOM   4743 C CD  . ARG C 3 145 ? 180.153 265.193 361.257 1.00 24.09 ? 145 ARG C CD  1 
ATOM   4744 N NE  . ARG C 3 145 ? 178.704 265.044 361.209 1.00 28.81 ? 145 ARG C NE  1 
ATOM   4745 C CZ  . ARG C 3 145 ? 178.061 263.896 361.363 1.00 19.72 ? 145 ARG C CZ  1 
ATOM   4746 N NH1 . ARG C 3 145 ? 178.709 262.764 361.572 1.00 26.22 ? 145 ARG C NH1 1 
ATOM   4747 N NH2 . ARG C 3 145 ? 176.734 263.884 361.302 1.00 21.54 ? 145 ARG C NH2 1 
ATOM   4748 N N   . LYS C 3 146 ? 178.353 270.069 360.867 1.00 23.32 ? 146 LYS C N   1 
ATOM   4749 C CA  . LYS C 3 146 ? 177.551 270.547 359.745 1.00 26.93 ? 146 LYS C CA  1 
ATOM   4750 C C   . LYS C 3 146 ? 178.270 271.662 358.994 1.00 30.95 ? 146 LYS C C   1 
ATOM   4751 O O   . LYS C 3 146 ? 178.309 271.668 357.759 1.00 30.17 ? 146 LYS C O   1 
ATOM   4752 C CB  . LYS C 3 146 ? 176.189 271.034 360.239 1.00 26.22 ? 146 LYS C CB  1 
ATOM   4753 C CG  . LYS C 3 146 ? 175.485 270.074 361.178 1.00 32.69 ? 146 LYS C CG  1 
ATOM   4754 C CD  . LYS C 3 146 ? 174.070 270.530 361.499 1.00 31.78 ? 146 LYS C CD  1 
ATOM   4755 C CE  . LYS C 3 146 ? 173.133 270.334 360.318 1.00 33.25 ? 146 LYS C CE  1 
ATOM   4756 N NZ  . LYS C 3 146 ? 171.735 270.715 360.648 1.00 34.90 ? 146 LYS C NZ  1 
ATOM   4757 N N   . GLU C 3 147 ? 178.845 272.615 359.729 1.00 31.04 ? 147 GLU C N   1 
ATOM   4758 C CA  . GLU C 3 147 ? 179.567 273.710 359.090 1.00 24.48 ? 147 GLU C CA  1 
ATOM   4759 C C   . GLU C 3 147 ? 180.904 273.240 358.534 1.00 24.29 ? 147 GLU C C   1 
ATOM   4760 O O   . GLU C 3 147 ? 181.329 273.691 357.465 1.00 30.40 ? 147 GLU C O   1 
ATOM   4761 C CB  . GLU C 3 147 ? 179.770 274.850 360.088 1.00 25.69 ? 147 GLU C CB  1 
ATOM   4762 C CG  . GLU C 3 147 ? 178.479 275.387 360.668 1.00 29.28 ? 147 GLU C CG  1 
ATOM   4763 C CD  . GLU C 3 147 ? 178.702 276.279 361.873 1.00 39.58 ? 147 GLU C CD  1 
ATOM   4764 O OE1 . GLU C 3 147 ? 179.230 277.398 361.702 1.00 34.99 ? 147 GLU C OE1 1 
ATOM   4765 O OE2 . GLU C 3 147 ? 178.354 275.854 362.996 1.00 38.72 ? 147 GLU C OE2 1 
ATOM   4766 N N   . ALA C 3 148 ? 181.579 272.332 359.242 1.00 21.91 ? 148 ALA C N   1 
ATOM   4767 C CA  . ALA C 3 148 ? 182.887 271.862 358.796 1.00 21.81 ? 148 ALA C CA  1 
ATOM   4768 C C   . ALA C 3 148 ? 182.780 271.051 357.513 1.00 21.12 ? 148 ALA C C   1 
ATOM   4769 O O   . ALA C 3 148 ? 183.672 271.105 356.660 1.00 26.91 ? 148 ALA C O   1 
ATOM   4770 C CB  . ALA C 3 148 ? 183.545 271.033 359.895 1.00 17.33 ? 148 ALA C CB  1 
ATOM   4771 N N   . MET C 3 149 ? 181.698 270.290 357.360 1.00 22.73 ? 149 MET C N   1 
ATOM   4772 C CA  . MET C 3 149 ? 181.522 269.458 356.178 1.00 22.04 ? 149 MET C CA  1 
ATOM   4773 C C   . MET C 3 149 ? 181.484 270.279 354.893 1.00 23.37 ? 149 MET C C   1 
ATOM   4774 O O   . MET C 3 149 ? 181.779 269.741 353.821 1.00 16.05 ? 149 MET C O   1 
ATOM   4775 C CB  . MET C 3 149 ? 180.243 268.629 356.351 1.00 26.80 ? 149 MET C CB  1 
ATOM   4776 C CG  . MET C 3 149 ? 179.614 268.104 355.072 1.00 26.77 ? 149 MET C CG  1 
ATOM   4777 S SD  . MET C 3 149 ? 178.415 269.244 354.358 1.00 36.94 ? 149 MET C SD  1 
ATOM   4778 C CE  . MET C 3 149 ? 177.120 269.217 355.590 1.00 18.09 ? 149 MET C CE  1 
ATOM   4779 N N   . LEU C 3 150 ? 181.158 271.571 354.975 1.00 27.40 ? 150 LEU C N   1 
ATOM   4780 C CA  . LEU C 3 150 ? 181.052 272.396 353.775 1.00 26.20 ? 150 LEU C CA  1 
ATOM   4781 C C   . LEU C 3 150 ? 182.408 272.762 353.182 1.00 18.34 ? 150 LEU C C   1 
ATOM   4782 O O   . LEU C 3 150 ? 182.474 273.113 352.001 1.00 19.90 ? 150 LEU C O   1 
ATOM   4783 C CB  . LEU C 3 150 ? 180.267 273.671 354.085 1.00 21.11 ? 150 LEU C CB  1 
ATOM   4784 C CG  . LEU C 3 150 ? 178.845 273.466 354.610 1.00 25.97 ? 150 LEU C CG  1 
ATOM   4785 C CD1 . LEU C 3 150 ? 178.219 274.796 354.970 1.00 19.23 ? 150 LEU C CD1 1 
ATOM   4786 C CD2 . LEU C 3 150 ? 177.979 272.727 353.598 1.00 23.40 ? 150 LEU C CD2 1 
ATOM   4787 N N   . GLY C 3 151 ? 183.484 272.703 353.965 1.00 24.00 ? 151 GLY C N   1 
ATOM   4788 C CA  . GLY C 3 151 ? 184.815 272.977 353.469 1.00 20.63 ? 151 GLY C CA  1 
ATOM   4789 C C   . GLY C 3 151 ? 185.504 271.722 352.971 1.00 17.19 ? 151 GLY C C   1 
ATOM   4790 O O   . GLY C 3 151 ? 184.915 270.644 352.880 1.00 23.52 ? 151 GLY C O   1 
ATOM   4791 N N   . THR C 3 152 ? 186.784 271.872 352.642 1.00 23.05 ? 152 THR C N   1 
ATOM   4792 C CA  . THR C 3 152 ? 187.576 270.716 352.240 1.00 19.74 ? 152 THR C CA  1 
ATOM   4793 C C   . THR C 3 152 ? 187.666 269.744 353.407 1.00 22.54 ? 152 THR C C   1 
ATOM   4794 O O   . THR C 3 152 ? 187.751 270.156 354.560 1.00 22.20 ? 152 THR C O   1 
ATOM   4795 C CB  . THR C 3 152 ? 188.976 271.154 351.804 1.00 18.51 ? 152 THR C CB  1 
ATOM   4796 O OG1 . THR C 3 152 ? 188.876 272.053 350.695 1.00 27.66 ? 152 THR C OG1 1 
ATOM   4797 C CG2 . THR C 3 152 ? 189.820 269.956 351.405 1.00 20.82 ? 152 THR C CG2 1 
ATOM   4798 N N   . HIS C 3 153 ? 187.622 268.448 353.122 1.00 20.38 ? 153 HIS C N   1 
ATOM   4799 C CA  . HIS C 3 153 ? 187.659 267.498 354.224 1.00 19.90 ? 153 HIS C CA  1 
ATOM   4800 C C   . HIS C 3 153 ? 187.965 266.100 353.714 1.00 21.95 ? 153 HIS C C   1 
ATOM   4801 O O   . HIS C 3 153 ? 187.857 265.807 352.522 1.00 27.54 ? 153 HIS C O   1 
ATOM   4802 C CB  . HIS C 3 153 ? 186.342 267.498 355.007 1.00 15.40 ? 153 HIS C CB  1 
ATOM   4803 C CG  . HIS C 3 153 ? 185.179 266.958 354.237 1.00 25.28 ? 153 HIS C CG  1 
ATOM   4804 N ND1 . HIS C 3 153 ? 184.359 267.757 353.471 1.00 27.61 ? 153 HIS C ND1 1 
ATOM   4805 C CD2 . HIS C 3 153 ? 184.697 265.699 354.116 1.00 21.31 ? 153 HIS C CD2 1 
ATOM   4806 C CE1 . HIS C 3 153 ? 183.423 267.015 352.911 1.00 23.52 ? 153 HIS C CE1 1 
ATOM   4807 N NE2 . HIS C 3 153 ? 183.605 265.762 353.287 1.00 27.03 ? 153 HIS C NE2 1 
ATOM   4808 N N   . VAL C 3 154 ? 188.362 265.248 354.654 1.00 17.10 ? 154 VAL C N   1 
ATOM   4809 C CA  . VAL C 3 154 ? 188.614 263.836 354.412 1.00 21.72 ? 154 VAL C CA  1 
ATOM   4810 C C   . VAL C 3 154 ? 187.980 263.031 355.540 1.00 18.76 ? 154 VAL C C   1 
ATOM   4811 O O   . VAL C 3 154 ? 187.806 263.521 356.662 1.00 22.46 ? 154 VAL C O   1 
ATOM   4812 C CB  . VAL C 3 154 ? 190.129 263.536 354.291 1.00 17.21 ? 154 VAL C CB  1 
ATOM   4813 C CG1 . VAL C 3 154 ? 190.886 264.046 355.512 1.00 21.68 ? 154 VAL C CG1 1 
ATOM   4814 C CG2 . VAL C 3 154 ? 190.370 262.051 354.094 1.00 20.72 ? 154 VAL C CG2 1 
ATOM   4815 N N   . ILE C 3 155 ? 187.626 261.786 355.228 1.00 14.00 ? 155 ILE C N   1 
ATOM   4816 C CA  . ILE C 3 155 ? 187.077 260.839 356.193 1.00 18.47 ? 155 ILE C CA  1 
ATOM   4817 C C   . ILE C 3 155 ? 188.145 259.799 356.496 1.00 18.03 ? 155 ILE C C   1 
ATOM   4818 O O   . ILE C 3 155 ? 188.701 259.181 355.582 1.00 18.68 ? 155 ILE C O   1 
ATOM   4819 C CB  . ILE C 3 155 ? 185.792 260.171 355.673 1.00 23.02 ? 155 ILE C CB  1 
ATOM   4820 C CG1 . ILE C 3 155 ? 184.686 261.208 355.469 1.00 18.79 ? 155 ILE C CG1 1 
ATOM   4821 C CG2 . ILE C 3 155 ? 185.327 259.086 356.640 1.00 17.73 ? 155 ILE C CG2 1 
ATOM   4822 C CD1 . ILE C 3 155 ? 184.270 261.921 356.733 1.00 23.04 ? 155 ILE C CD1 1 
ATOM   4823 N N   . TRP C 3 156 ? 188.427 259.612 357.778 1.00 21.16 ? 156 TRP C N   1 
ATOM   4824 C CA  . TRP C 3 156 ? 189.484 258.736 358.260 1.00 18.00 ? 156 TRP C CA  1 
ATOM   4825 C C   . TRP C 3 156 ? 188.850 257.543 358.961 1.00 18.60 ? 156 TRP C C   1 
ATOM   4826 O O   . TRP C 3 156 ? 188.150 257.710 359.963 1.00 16.50 ? 156 TRP C O   1 
ATOM   4827 C CB  . TRP C 3 156 ? 190.400 259.501 359.214 1.00 15.73 ? 156 TRP C CB  1 
ATOM   4828 C CG  . TRP C 3 156 ? 191.486 258.691 359.844 1.00 20.19 ? 156 TRP C CG  1 
ATOM   4829 C CD1 . TRP C 3 156 ? 191.972 257.489 359.422 1.00 17.60 ? 156 TRP C CD1 1 
ATOM   4830 C CD2 . TRP C 3 156 ? 192.227 259.032 361.019 1.00 19.38 ? 156 TRP C CD2 1 
ATOM   4831 N NE1 . TRP C 3 156 ? 192.971 257.063 360.259 1.00 18.31 ? 156 TRP C NE1 1 
ATOM   4832 C CE2 . TRP C 3 156 ? 193.147 257.993 361.249 1.00 19.05 ? 156 TRP C CE2 1 
ATOM   4833 C CE3 . TRP C 3 156 ? 192.202 260.117 361.899 1.00 19.52 ? 156 TRP C CE3 1 
ATOM   4834 C CZ2 . TRP C 3 156 ? 194.033 258.006 362.322 1.00 18.39 ? 156 TRP C CZ2 1 
ATOM   4835 C CZ3 . TRP C 3 156 ? 193.083 260.127 362.964 1.00 18.55 ? 156 TRP C CZ3 1 
ATOM   4836 C CH2 . TRP C 3 156 ? 193.984 259.080 363.166 1.00 16.09 ? 156 TRP C CH2 1 
ATOM   4837 N N   . ASP C 3 157 ? 189.104 256.349 358.440 1.00 21.51 ? 157 ASP C N   1 
ATOM   4838 C CA  . ASP C 3 157 ? 188.678 255.103 359.067 1.00 20.25 ? 157 ASP C CA  1 
ATOM   4839 C C   . ASP C 3 157 ? 189.873 254.526 359.816 1.00 19.75 ? 157 ASP C C   1 
ATOM   4840 O O   . ASP C 3 157 ? 190.814 254.022 359.196 1.00 25.21 ? 157 ASP C O   1 
ATOM   4841 C CB  . ASP C 3 157 ? 188.154 254.126 358.018 1.00 20.92 ? 157 ASP C CB  1 
ATOM   4842 C CG  . ASP C 3 157 ? 187.462 252.925 358.625 1.00 29.91 ? 157 ASP C CG  1 
ATOM   4843 O OD1 . ASP C 3 157 ? 187.241 252.905 359.852 1.00 34.75 ? 157 ASP C OD1 1 
ATOM   4844 O OD2 . ASP C 3 157 ? 187.132 251.994 357.866 1.00 32.99 ? 157 ASP C OD2 1 
ATOM   4845 N N   . ILE C 3 158 ? 189.843 254.604 361.147 1.00 17.04 ? 158 ILE C N   1 
ATOM   4846 C CA  . ILE C 3 158 ? 190.980 254.130 361.931 1.00 25.82 ? 158 ILE C CA  1 
ATOM   4847 C C   . ILE C 3 158 ? 191.121 252.622 361.799 1.00 25.53 ? 158 ILE C C   1 
ATOM   4848 O O   . ILE C 3 158 ? 192.237 252.091 361.750 1.00 32.31 ? 158 ILE C O   1 
ATOM   4849 C CB  . ILE C 3 158 ? 190.850 254.559 363.404 1.00 26.05 ? 158 ILE C CB  1 
ATOM   4850 C CG1 . ILE C 3 158 ? 189.739 253.772 364.103 1.00 25.98 ? 158 ILE C CG1 1 
ATOM   4851 C CG2 . ILE C 3 158 ? 190.596 256.051 363.494 1.00 24.91 ? 158 ILE C CG2 1 
ATOM   4852 C CD1 . ILE C 3 158 ? 189.467 254.229 365.511 1.00 24.69 ? 158 ILE C CD1 1 
ATOM   4853 N N   . GLY C 3 159 ? 189.999 251.907 361.737 1.00 30.79 ? 159 GLY C N   1 
ATOM   4854 C CA  . GLY C 3 159 ? 190.064 250.470 361.557 1.00 29.39 ? 159 GLY C CA  1 
ATOM   4855 C C   . GLY C 3 159 ? 190.776 250.073 360.282 1.00 28.38 ? 159 GLY C C   1 
ATOM   4856 O O   . GLY C 3 159 ? 191.499 249.075 360.256 1.00 34.09 ? 159 GLY C O   1 
ATOM   4857 N N   . LEU C 3 160 ? 190.583 250.837 359.210 1.00 25.67 ? 160 LEU C N   1 
ATOM   4858 C CA  . LEU C 3 160 ? 191.260 250.564 357.950 1.00 26.54 ? 160 LEU C CA  1 
ATOM   4859 C C   . LEU C 3 160 ? 192.735 250.953 357.985 1.00 31.72 ? 160 LEU C C   1 
ATOM   4860 O O   . LEU C 3 160 ? 193.582 250.194 357.503 1.00 33.57 ? 160 LEU C O   1 
ATOM   4861 C CB  . LEU C 3 160 ? 190.553 251.299 356.809 1.00 31.01 ? 160 LEU C CB  1 
ATOM   4862 C CG  . LEU C 3 160 ? 191.077 251.035 355.398 1.00 33.41 ? 160 LEU C CG  1 
ATOM   4863 C CD1 . LEU C 3 160 ? 190.848 249.585 354.988 1.00 28.96 ? 160 LEU C CD1 1 
ATOM   4864 C CD2 . LEU C 3 160 ? 190.425 251.982 354.406 1.00 30.34 ? 160 LEU C CD2 1 
ATOM   4865 N N   . GLN C 3 161 ? 193.067 252.115 358.546 1.00 31.07 ? 161 GLN C N   1 
ATOM   4866 C CA  . GLN C 3 161 ? 194.455 252.557 358.614 1.00 25.42 ? 161 GLN C CA  1 
ATOM   4867 C C   . GLN C 3 161 ? 194.643 253.461 359.822 1.00 23.51 ? 161 GLN C C   1 
ATOM   4868 O O   . GLN C 3 161 ? 193.750 254.240 360.162 1.00 27.29 ? 161 GLN C O   1 
ATOM   4869 C CB  . GLN C 3 161 ? 194.865 253.280 357.327 1.00 25.03 ? 161 GLN C CB  1 
ATOM   4870 C CG  . GLN C 3 161 ? 194.174 254.600 357.089 1.00 25.46 ? 161 GLN C CG  1 
ATOM   4871 C CD  . GLN C 3 161 ? 194.452 255.150 355.704 1.00 31.28 ? 161 GLN C CD  1 
ATOM   4872 O OE1 . GLN C 3 161 ? 194.338 254.438 354.709 1.00 31.11 ? 161 GLN C OE1 1 
ATOM   4873 N NE2 . GLN C 3 161 ? 194.823 256.422 355.634 1.00 30.68 ? 161 GLN C NE2 1 
ATOM   4874 N N   . SER C 3 162 ? 195.806 253.354 360.463 1.00 22.95 ? 162 SER C N   1 
ATOM   4875 C CA  . SER C 3 162 ? 196.079 254.051 361.713 1.00 22.36 ? 162 SER C CA  1 
ATOM   4876 C C   . SER C 3 162 ? 196.611 255.464 361.524 1.00 23.36 ? 162 SER C C   1 
ATOM   4877 O O   . SER C 3 162 ? 196.639 256.227 362.494 1.00 21.16 ? 162 SER C O   1 
ATOM   4878 C CB  . SER C 3 162 ? 197.085 253.255 362.548 1.00 18.16 ? 162 SER C CB  1 
ATOM   4879 O OG  . SER C 3 162 ? 196.571 251.985 362.891 1.00 26.32 ? 162 SER C OG  1 
ATOM   4880 N N   . SER C 3 163 ? 197.037 255.833 360.320 1.00 22.29 ? 163 SER C N   1 
ATOM   4881 C CA  . SER C 3 163 ? 197.538 257.172 360.049 1.00 18.72 ? 163 SER C CA  1 
ATOM   4882 C C   . SER C 3 163 ? 196.857 257.710 358.803 1.00 21.74 ? 163 SER C C   1 
ATOM   4883 O O   . SER C 3 163 ? 196.709 256.989 357.813 1.00 24.20 ? 163 SER C O   1 
ATOM   4884 C CB  . SER C 3 163 ? 199.060 257.182 359.871 1.00 20.93 ? 163 SER C CB  1 
ATOM   4885 O OG  . SER C 3 163 ? 199.438 256.634 358.623 1.00 26.55 ? 163 SER C OG  1 
ATOM   4886 N N   . CYS C 3 164 ? 196.435 258.971 358.859 1.00 23.57 ? 164 CYS C N   1 
ATOM   4887 C CA  . CYS C 3 164 ? 195.747 259.609 357.746 1.00 12.31 ? 164 CYS C CA  1 
ATOM   4888 C C   . CYS C 3 164 ? 196.298 261.008 357.523 1.00 16.47 ? 164 CYS C C   1 
ATOM   4889 O O   . CYS C 3 164 ? 196.502 261.764 358.474 1.00 21.91 ? 164 CYS C O   1 
ATOM   4890 C CB  . CYS C 3 164 ? 194.240 259.678 357.992 1.00 24.20 ? 164 CYS C CB  1 
ATOM   4891 S SG  . CYS C 3 164 ? 193.266 260.108 356.528 1.00 26.13 ? 164 CYS C SG  1 
ATOM   4892 N N   . THR C 3 165 ? 196.516 261.352 356.258 1.00 19.77 ? 165 THR C N   1 
ATOM   4893 C CA  . THR C 3 165 ? 197.102 262.627 355.868 1.00 15.32 ? 165 THR C CA  1 
ATOM   4894 C C   . THR C 3 165 ? 196.059 263.463 355.141 1.00 18.00 ? 165 THR C C   1 
ATOM   4895 O O   . THR C 3 165 ? 195.412 262.981 354.207 1.00 26.49 ? 165 THR C O   1 
ATOM   4896 C CB  . THR C 3 165 ? 198.322 262.420 354.971 1.00 19.48 ? 165 THR C CB  1 
ATOM   4897 O OG1 . THR C 3 165 ? 199.355 261.755 355.703 1.00 25.72 ? 165 THR C OG1 1 
ATOM   4898 C CG2 . THR C 3 165 ? 198.847 263.758 354.464 1.00 21.99 ? 165 THR C CG2 1 
ATOM   4899 N N   . MET C 3 166 ? 195.902 264.710 355.568 1.00 19.94 ? 166 MET C N   1 
ATOM   4900 C CA  . MET C 3 166 ? 195.135 265.706 354.835 1.00 19.65 ? 166 MET C CA  1 
ATOM   4901 C C   . MET C 3 166 ? 196.095 266.784 354.348 1.00 20.46 ? 166 MET C C   1 
ATOM   4902 O O   . MET C 3 166 ? 196.822 267.387 355.147 1.00 22.88 ? 166 MET C O   1 
ATOM   4903 C CB  . MET C 3 166 ? 194.032 266.320 355.696 1.00 16.23 ? 166 MET C CB  1 
ATOM   4904 C CG  . MET C 3 166 ? 193.078 267.194 354.891 1.00 27.67 ? 166 MET C CG  1 
ATOM   4905 S SD  . MET C 3 166 ? 191.785 267.997 355.853 1.00 38.63 ? 166 MET C SD  1 
ATOM   4906 C CE  . MET C 3 166 ? 192.745 269.090 356.889 1.00 21.87 ? 166 MET C CE  1 
ATOM   4907 N N   . VAL C 3 167 ? 196.105 267.008 353.040 1.00 19.61 ? 167 VAL C N   1 
ATOM   4908 C CA  . VAL C 3 167 ? 196.863 268.107 352.459 1.00 19.73 ? 167 VAL C CA  1 
ATOM   4909 C C   . VAL C 3 167 ? 195.968 269.336 352.428 1.00 16.07 ? 167 VAL C C   1 
ATOM   4910 O O   . VAL C 3 167 ? 194.861 269.296 351.884 1.00 22.29 ? 167 VAL C O   1 
ATOM   4911 C CB  . VAL C 3 167 ? 197.366 267.754 351.053 1.00 18.05 ? 167 VAL C CB  1 
ATOM   4912 C CG1 . VAL C 3 167 ? 197.883 268.997 350.353 1.00 19.82 ? 167 VAL C CG1 1 
ATOM   4913 C CG2 . VAL C 3 167 ? 198.450 266.698 351.130 1.00 18.79 ? 167 VAL C CG2 1 
ATOM   4914 N N   . VAL C 3 168 ? 196.432 270.420 353.041 1.00 17.66 ? 168 VAL C N   1 
ATOM   4915 C CA  . VAL C 3 168 ? 195.786 271.724 352.932 1.00 18.78 ? 168 VAL C CA  1 
ATOM   4916 C C   . VAL C 3 168 ? 196.424 272.448 351.747 1.00 14.14 ? 168 VAL C C   1 
ATOM   4917 O O   . VAL C 3 168 ? 197.577 272.896 351.863 1.00 14.10 ? 168 VAL C O   1 
ATOM   4918 C CB  . VAL C 3 168 ? 195.933 272.536 354.224 1.00 17.83 ? 168 VAL C CB  1 
ATOM   4919 C CG1 . VAL C 3 168 ? 195.297 273.899 354.067 1.00 14.57 ? 168 VAL C CG1 1 
ATOM   4920 C CG2 . VAL C 3 168 ? 195.307 271.791 355.386 1.00 15.46 ? 168 VAL C CG2 1 
ATOM   4921 N N   . PRO C 3 169 ? 195.746 272.555 350.607 1.00 21.06 ? 169 PRO C N   1 
ATOM   4922 C CA  . PRO C 3 169 ? 196.349 273.225 349.455 1.00 16.42 ? 169 PRO C CA  1 
ATOM   4923 C C   . PRO C 3 169 ? 196.432 274.727 349.659 1.00 18.28 ? 169 PRO C C   1 
ATOM   4924 O O   . PRO C 3 169 ? 195.668 275.324 350.420 1.00 22.11 ? 169 PRO C O   1 
ATOM   4925 C CB  . PRO C 3 169 ? 195.401 272.875 348.298 1.00 15.21 ? 169 PRO C CB  1 
ATOM   4926 C CG  . PRO C 3 169 ? 194.513 271.791 348.817 1.00 22.58 ? 169 PRO C CG  1 
ATOM   4927 C CD  . PRO C 3 169 ? 194.416 272.021 350.279 1.00 17.78 ? 169 PRO C CD  1 
ATOM   4928 N N   . TRP C 3 170 ? 197.383 275.331 348.958 1.00 15.75 ? 170 TRP C N   1 
ATOM   4929 C CA  . TRP C 3 170 ? 197.595 276.767 349.045 1.00 9.93  ? 170 TRP C CA  1 
ATOM   4930 C C   . TRP C 3 170 ? 196.419 277.521 348.436 1.00 15.45 ? 170 TRP C C   1 
ATOM   4931 O O   . TRP C 3 170 ? 196.150 277.410 347.237 1.00 20.40 ? 170 TRP C O   1 
ATOM   4932 C CB  . TRP C 3 170 ? 198.897 277.127 348.334 1.00 10.75 ? 170 TRP C CB  1 
ATOM   4933 C CG  . TRP C 3 170 ? 199.198 278.591 348.281 1.00 9.96  ? 170 TRP C CG  1 
ATOM   4934 C CD1 . TRP C 3 170 ? 199.237 279.372 347.170 1.00 6.17  ? 170 TRP C CD1 1 
ATOM   4935 C CD2 . TRP C 3 170 ? 199.507 279.447 349.385 1.00 13.82 ? 170 TRP C CD2 1 
ATOM   4936 N NE1 . TRP C 3 170 ? 199.554 280.662 347.508 1.00 16.95 ? 170 TRP C NE1 1 
ATOM   4937 C CE2 . TRP C 3 170 ? 199.727 280.735 348.864 1.00 11.22 ? 170 TRP C CE2 1 
ATOM   4938 C CE3 . TRP C 3 170 ? 199.625 279.250 350.761 1.00 11.82 ? 170 TRP C CE3 1 
ATOM   4939 C CZ2 . TRP C 3 170 ? 200.059 281.819 349.669 1.00 5.28  ? 170 TRP C CZ2 1 
ATOM   4940 C CZ3 . TRP C 3 170 ? 199.956 280.328 351.558 1.00 13.13 ? 170 TRP C CZ3 1 
ATOM   4941 C CH2 . TRP C 3 170 ? 200.167 281.596 351.010 1.00 10.67 ? 170 TRP C CH2 1 
ATOM   4942 N N   . ILE C 3 171 ? 195.711 278.277 349.270 1.00 8.17  ? 171 ILE C N   1 
ATOM   4943 C CA  . ILE C 3 171 ? 194.620 279.129 348.813 1.00 12.13 ? 171 ILE C CA  1 
ATOM   4944 C C   . ILE C 3 171 ? 194.717 280.462 349.544 1.00 18.80 ? 171 ILE C C   1 
ATOM   4945 O O   . ILE C 3 171 ? 194.454 280.548 350.747 1.00 17.81 ? 171 ILE C O   1 
ATOM   4946 C CB  . ILE C 3 171 ? 193.248 278.456 349.022 1.00 13.04 ? 171 ILE C CB  1 
ATOM   4947 C CG1 . ILE C 3 171 ? 192.119 279.416 348.640 1.00 17.41 ? 171 ILE C CG1 1 
ATOM   4948 C CG2 . ILE C 3 171 ? 193.069 277.984 350.456 1.00 19.59 ? 171 ILE C CG2 1 
ATOM   4949 C CD1 . ILE C 3 171 ? 191.028 278.773 347.846 1.00 12.18 ? 171 ILE C CD1 1 
ATOM   4950 N N   . SER C 3 172 ? 195.111 281.508 348.824 1.00 22.04 ? 172 SER C N   1 
ATOM   4951 C CA  . SER C 3 172 ? 195.350 282.810 349.425 1.00 11.47 ? 172 SER C CA  1 
ATOM   4952 C C   . SER C 3 172 ? 194.993 283.907 348.435 1.00 13.07 ? 172 SER C C   1 
ATOM   4953 O O   . SER C 3 172 ? 195.111 283.731 347.221 1.00 20.06 ? 172 SER C O   1 
ATOM   4954 C CB  . SER C 3 172 ? 196.816 282.957 349.857 1.00 12.70 ? 172 SER C CB  1 
ATOM   4955 O OG  . SER C 3 172 ? 196.994 284.090 350.682 1.00 18.20 ? 172 SER C OG  1 
ATOM   4956 N N   . ASN C 3 173 ? 194.547 285.045 348.968 1.00 5.83  ? 173 ASN C N   1 
ATOM   4957 C CA  . ASN C 3 173 ? 194.393 286.229 348.131 1.00 14.70 ? 173 ASN C CA  1 
ATOM   4958 C C   . ASN C 3 173 ? 195.755 286.805 347.753 1.00 15.17 ? 173 ASN C C   1 
ATOM   4959 O O   . ASN C 3 173 ? 195.999 287.133 346.588 1.00 22.31 ? 173 ASN C O   1 
ATOM   4960 C CB  . ASN C 3 173 ? 193.534 287.275 348.844 1.00 13.00 ? 173 ASN C CB  1 
ATOM   4961 C CG  . ASN C 3 173 ? 194.030 287.588 350.237 1.00 17.65 ? 173 ASN C CG  1 
ATOM   4962 O OD1 . ASN C 3 173 ? 195.110 287.161 350.629 1.00 26.18 ? 173 ASN C OD1 1 
ATOM   4963 N ND2 . ASN C 3 173 ? 193.242 288.340 350.990 1.00 18.85 ? 173 ASN C ND2 1 
ATOM   4964 N N   . THR C 3 174 ? 196.661 286.910 348.720 1.00 16.36 ? 174 THR C N   1 
ATOM   4965 C CA  . THR C 3 174 ? 198.005 287.395 348.457 1.00 11.46 ? 174 THR C CA  1 
ATOM   4966 C C   . THR C 3 174 ? 198.900 286.258 347.971 1.00 15.34 ? 174 THR C C   1 
ATOM   4967 O O   . THR C 3 174 ? 198.609 285.075 348.160 1.00 18.58 ? 174 THR C O   1 
ATOM   4968 C CB  . THR C 3 174 ? 198.609 288.028 349.710 1.00 14.99 ? 174 THR C CB  1 
ATOM   4969 O OG1 . THR C 3 174 ? 198.660 287.058 350.761 1.00 21.46 ? 174 THR C OG1 1 
ATOM   4970 C CG2 . THR C 3 174 ? 197.781 289.214 350.167 1.00 6.84  ? 174 THR C CG2 1 
ATOM   4971 N N   . THR C 3 175 ? 200.008 286.638 347.332 1.00 18.62 ? 175 THR C N   1 
ATOM   4972 C CA  . THR C 3 175 ? 200.952 285.644 346.830 1.00 11.56 ? 175 THR C CA  1 
ATOM   4973 C C   . THR C 3 175 ? 201.743 285.000 347.963 1.00 4.33  ? 175 THR C C   1 
ATOM   4974 O O   . THR C 3 175 ? 202.164 283.846 347.843 1.00 4.56  ? 175 THR C O   1 
ATOM   4975 C CB  . THR C 3 175 ? 201.898 286.288 345.817 1.00 13.96 ? 175 THR C CB  1 
ATOM   4976 O OG1 . THR C 3 175 ? 201.145 287.094 344.904 1.00 20.19 ? 175 THR C OG1 1 
ATOM   4977 C CG2 . THR C 3 175 ? 202.642 285.229 345.032 1.00 19.41 ? 175 THR C CG2 1 
ATOM   4978 N N   . TYR C 3 176 ? 201.958 285.723 349.059 1.00 6.78  ? 176 TYR C N   1 
ATOM   4979 C CA  . TYR C 3 176 ? 202.573 285.174 350.256 1.00 4.26  ? 176 TYR C CA  1 
ATOM   4980 C C   . TYR C 3 176 ? 201.779 285.629 351.467 1.00 8.88  ? 176 TYR C C   1 
ATOM   4981 O O   . TYR C 3 176 ? 201.108 286.661 351.434 1.00 13.67 ? 176 TYR C O   1 
ATOM   4982 C CB  . TYR C 3 176 ? 204.037 285.612 350.423 1.00 12.05 ? 176 TYR C CB  1 
ATOM   4983 C CG  . TYR C 3 176 ? 204.987 285.024 349.409 1.00 8.88  ? 176 TYR C CG  1 
ATOM   4984 C CD1 . TYR C 3 176 ? 205.114 285.581 348.149 1.00 4.42  ? 176 TYR C CD1 1 
ATOM   4985 C CD2 . TYR C 3 176 ? 205.755 283.913 349.714 1.00 7.07  ? 176 TYR C CD2 1 
ATOM   4986 C CE1 . TYR C 3 176 ? 205.969 285.046 347.220 1.00 8.03  ? 176 TYR C CE1 1 
ATOM   4987 C CE2 . TYR C 3 176 ? 206.618 283.372 348.790 1.00 9.59  ? 176 TYR C CE2 1 
ATOM   4988 C CZ  . TYR C 3 176 ? 206.721 283.944 347.542 1.00 13.27 ? 176 TYR C CZ  1 
ATOM   4989 O OH  . TYR C 3 176 ? 207.580 283.416 346.608 1.00 25.17 ? 176 TYR C OH  1 
ATOM   4990 N N   . ARG C 3 177 ? 201.858 284.848 352.532 1.00 14.35 ? 177 ARG C N   1 
ATOM   4991 C CA  . ARG C 3 177 ? 201.324 285.241 353.824 1.00 7.36  ? 177 ARG C CA  1 
ATOM   4992 C C   . ARG C 3 177 ? 202.463 285.682 354.732 1.00 13.94 ? 177 ARG C C   1 
ATOM   4993 O O   . ARG C 3 177 ? 203.620 285.308 354.540 1.00 14.83 ? 177 ARG C O   1 
ATOM   4994 C CB  . ARG C 3 177 ? 200.543 284.093 354.471 1.00 9.34  ? 177 ARG C CB  1 
ATOM   4995 C CG  . ARG C 3 177 ? 199.209 283.799 353.812 1.00 10.26 ? 177 ARG C CG  1 
ATOM   4996 C CD  . ARG C 3 177 ? 198.398 282.788 354.603 1.00 10.83 ? 177 ARG C CD  1 
ATOM   4997 N NE  . ARG C 3 177 ? 197.007 282.738 354.164 1.00 20.24 ? 177 ARG C NE  1 
ATOM   4998 C CZ  . ARG C 3 177 ? 196.480 281.800 353.388 1.00 16.64 ? 177 ARG C CZ  1 
ATOM   4999 N NH1 . ARG C 3 177 ? 197.193 280.777 352.953 1.00 15.77 ? 177 ARG C NH1 1 
ATOM   5000 N NH2 . ARG C 3 177 ? 195.198 281.886 353.049 1.00 11.65 ? 177 ARG C NH2 1 
ATOM   5001 N N   . LEU C 3 178 ? 202.124 286.499 355.718 1.00 16.03 ? 178 LEU C N   1 
ATOM   5002 C CA  . LEU C 3 178 ? 203.089 286.917 356.719 1.00 8.94  ? 178 LEU C CA  1 
ATOM   5003 C C   . LEU C 3 178 ? 203.212 285.849 357.797 1.00 15.42 ? 178 LEU C C   1 
ATOM   5004 O O   . LEU C 3 178 ? 202.257 285.129 358.098 1.00 17.69 ? 178 LEU C O   1 
ATOM   5005 C CB  . LEU C 3 178 ? 202.680 288.251 357.344 1.00 15.72 ? 178 LEU C CB  1 
ATOM   5006 C CG  . LEU C 3 178 ? 202.525 289.422 356.373 1.00 14.55 ? 178 LEU C CG  1 
ATOM   5007 C CD1 . LEU C 3 178 ? 202.176 290.692 357.123 1.00 14.73 ? 178 LEU C CD1 1 
ATOM   5008 C CD2 . LEU C 3 178 ? 203.780 289.618 355.546 1.00 13.12 ? 178 LEU C CD2 1 
ATOM   5009 N N   . THR C 3 179 ? 204.405 285.745 358.376 1.00 14.46 ? 179 THR C N   1 
ATOM   5010 C CA  . THR C 3 179 ? 204.668 284.771 359.425 1.00 13.61 ? 179 THR C CA  1 
ATOM   5011 C C   . THR C 3 179 ? 204.249 285.269 360.800 1.00 9.82  ? 179 THR C C   1 
ATOM   5012 O O   . THR C 3 179 ? 204.682 284.709 361.811 1.00 27.12 ? 179 THR C O   1 
ATOM   5013 C CB  . THR C 3 179 ? 206.149 284.384 359.436 1.00 10.30 ? 179 THR C CB  1 
ATOM   5014 O OG1 . THR C 3 179 ? 206.947 285.539 359.705 1.00 17.70 ? 179 THR C OG1 1 
ATOM   5015 C CG2 . THR C 3 179 ? 206.559 283.783 358.103 1.00 8.43  ? 179 THR C CG2 1 
ATOM   5016 N N   . ILE C 3 180 ? 203.414 286.301 360.860 1.00 15.89 ? 180 ILE C N   1 
ATOM   5017 C CA  . ILE C 3 180 ? 202.853 286.794 362.108 1.00 20.60 ? 180 ILE C CA  1 
ATOM   5018 C C   . ILE C 3 180 ? 201.334 286.712 362.015 1.00 17.32 ? 180 ILE C C   1 
ATOM   5019 O O   . ILE C 3 180 ? 200.769 286.435 360.959 1.00 20.84 ? 180 ILE C O   1 
ATOM   5020 C CB  . ILE C 3 180 ? 203.309 288.232 362.441 1.00 19.20 ? 180 ILE C CB  1 
ATOM   5021 C CG1 . ILE C 3 180 ? 203.132 289.183 361.250 1.00 17.33 ? 180 ILE C CG1 1 
ATOM   5022 C CG2 . ILE C 3 180 ? 204.746 288.237 362.887 1.00 18.43 ? 180 ILE C CG2 1 
ATOM   5023 C CD1 . ILE C 3 180 ? 201.819 289.910 361.235 1.00 20.11 ? 180 ILE C CD1 1 
ATOM   5024 N N   . ASN C 3 181 ? 200.677 286.947 363.146 1.00 18.70 ? 181 ASN C N   1 
ATOM   5025 C CA  . ASN C 3 181 ? 199.219 286.974 363.178 1.00 22.34 ? 181 ASN C CA  1 
ATOM   5026 C C   . ASN C 3 181 ? 198.731 288.252 362.509 1.00 23.07 ? 181 ASN C C   1 
ATOM   5027 O O   . ASN C 3 181 ? 198.884 289.348 363.055 1.00 27.29 ? 181 ASN C O   1 
ATOM   5028 C CB  . ASN C 3 181 ? 198.712 286.878 364.613 1.00 21.34 ? 181 ASN C CB  1 
ATOM   5029 C CG  . ASN C 3 181 ? 198.728 285.456 365.144 1.00 31.10 ? 181 ASN C CG  1 
ATOM   5030 O OD1 . ASN C 3 181 ? 198.631 284.495 364.382 1.00 30.37 ? 181 ASN C OD1 1 
ATOM   5031 N ND2 . ASN C 3 181 ? 198.848 285.316 366.459 1.00 29.16 ? 181 ASN C ND2 1 
ATOM   5032 N N   . ASP C 3 182 ? 198.155 288.112 361.319 1.00 21.40 ? 182 ASP C N   1 
ATOM   5033 C CA  . ASP C 3 182 ? 197.642 289.240 360.558 1.00 21.07 ? 182 ASP C CA  1 
ATOM   5034 C C   . ASP C 3 182 ? 196.319 288.848 359.921 1.00 15.86 ? 182 ASP C C   1 
ATOM   5035 O O   . ASP C 3 182 ? 196.217 287.787 359.300 1.00 20.05 ? 182 ASP C O   1 
ATOM   5036 C CB  . ASP C 3 182 ? 198.650 289.679 359.489 1.00 19.67 ? 182 ASP C CB  1 
ATOM   5037 C CG  . ASP C 3 182 ? 198.066 290.663 358.508 1.00 27.64 ? 182 ASP C CG  1 
ATOM   5038 O OD1 . ASP C 3 182 ? 197.567 291.718 358.947 1.00 33.88 ? 182 ASP C OD1 1 
ATOM   5039 O OD2 . ASP C 3 182 ? 198.112 290.384 357.295 1.00 28.97 ? 182 ASP C OD2 1 
ATOM   5040 N N   . SER C 3 183 ? 195.309 289.707 360.079 1.00 17.59 ? 183 SER C N   1 
ATOM   5041 C CA  . SER C 3 183 ? 193.980 289.399 359.563 1.00 20.15 ? 183 SER C CA  1 
ATOM   5042 C C   . SER C 3 183 ? 193.971 289.322 358.043 1.00 21.17 ? 183 SER C C   1 
ATOM   5043 O O   . SER C 3 183 ? 193.317 288.447 357.466 1.00 19.42 ? 183 SER C O   1 
ATOM   5044 C CB  . SER C 3 183 ? 192.977 290.446 360.041 1.00 19.83 ? 183 SER C CB  1 
ATOM   5045 O OG  . SER C 3 183 ? 192.857 290.427 361.449 1.00 26.69 ? 183 SER C OG  1 
ATOM   5046 N N   . PHE C 3 184 ? 194.681 290.231 357.376 1.00 11.10 ? 184 PHE C N   1 
ATOM   5047 C CA  . PHE C 3 184 ? 194.607 290.286 355.922 1.00 15.46 ? 184 PHE C CA  1 
ATOM   5048 C C   . PHE C 3 184 ? 195.183 289.031 355.275 1.00 19.45 ? 184 PHE C C   1 
ATOM   5049 O O   . PHE C 3 184 ? 194.780 288.669 354.165 1.00 14.38 ? 184 PHE C O   1 
ATOM   5050 C CB  . PHE C 3 184 ? 195.327 291.533 355.409 1.00 16.27 ? 184 PHE C CB  1 
ATOM   5051 C CG  . PHE C 3 184 ? 195.165 291.755 353.936 1.00 15.91 ? 184 PHE C CG  1 
ATOM   5052 C CD1 . PHE C 3 184 ? 193.975 292.236 353.424 1.00 18.48 ? 184 PHE C CD1 1 
ATOM   5053 C CD2 . PHE C 3 184 ? 196.199 291.480 353.062 1.00 14.86 ? 184 PHE C CD2 1 
ATOM   5054 C CE1 . PHE C 3 184 ? 193.818 292.438 352.070 1.00 16.12 ? 184 PHE C CE1 1 
ATOM   5055 C CE2 . PHE C 3 184 ? 196.048 291.681 351.707 1.00 21.71 ? 184 PHE C CE2 1 
ATOM   5056 C CZ  . PHE C 3 184 ? 194.855 292.160 351.210 1.00 17.09 ? 184 PHE C CZ  1 
ATOM   5057 N N   . THR C 3 185 ? 196.116 288.354 355.946 1.00 17.36 ? 185 THR C N   1 
ATOM   5058 C CA  . THR C 3 185 ? 196.738 287.143 355.421 1.00 12.04 ? 185 THR C CA  1 
ATOM   5059 C C   . THR C 3 185 ? 196.402 285.923 356.276 1.00 13.82 ? 185 THR C C   1 
ATOM   5060 O O   . THR C 3 185 ? 197.215 285.010 356.411 1.00 19.74 ? 185 THR C O   1 
ATOM   5061 C CB  . THR C 3 185 ? 198.256 287.316 355.307 1.00 27.92 ? 185 THR C CB  1 
ATOM   5062 O OG1 . THR C 3 185 ? 198.783 287.834 356.536 1.00 29.06 ? 185 THR C OG1 1 
ATOM   5063 C CG2 . THR C 3 185 ? 198.609 288.260 354.168 1.00 13.17 ? 185 THR C CG2 1 
ATOM   5064 N N   . GLU C 3 186 ? 195.205 285.893 356.853 1.00 21.90 ? 186 GLU C N   1 
ATOM   5065 C CA  . GLU C 3 186 ? 194.777 284.741 357.636 1.00 10.45 ? 186 GLU C CA  1 
ATOM   5066 C C   . GLU C 3 186 ? 194.649 283.507 356.748 1.00 17.09 ? 186 GLU C C   1 
ATOM   5067 O O   . GLU C 3 186 ? 194.421 283.602 355.540 1.00 19.88 ? 186 GLU C O   1 
ATOM   5068 C CB  . GLU C 3 186 ? 193.454 285.038 358.338 1.00 14.89 ? 186 GLU C CB  1 
ATOM   5069 C CG  . GLU C 3 186 ? 192.339 285.497 357.416 1.00 24.42 ? 186 GLU C CG  1 
ATOM   5070 C CD  . GLU C 3 186 ? 191.098 285.927 358.172 1.00 24.52 ? 186 GLU C CD  1 
ATOM   5071 O OE1 . GLU C 3 186 ? 191.079 285.791 359.411 1.00 26.73 ? 186 GLU C OE1 1 
ATOM   5072 O OE2 . GLU C 3 186 ? 190.145 286.411 357.529 1.00 24.28 ? 186 GLU C OE2 1 
ATOM   5073 N N   . GLY C 3 187 ? 194.811 282.335 357.360 1.00 15.80 ? 187 GLY C N   1 
ATOM   5074 C CA  . GLY C 3 187 ? 194.958 281.102 356.610 1.00 15.65 ? 187 GLY C CA  1 
ATOM   5075 C C   . GLY C 3 187 ? 193.729 280.219 356.549 1.00 15.73 ? 187 GLY C C   1 
ATOM   5076 O O   . GLY C 3 187 ? 193.487 279.569 355.531 1.00 14.77 ? 187 GLY C O   1 
ATOM   5077 N N   . GLY C 3 188 ? 192.954 280.174 357.624 1.00 15.01 ? 188 GLY C N   1 
ATOM   5078 C CA  . GLY C 3 188 ? 191.772 279.348 357.693 1.00 17.46 ? 188 GLY C CA  1 
ATOM   5079 C C   . GLY C 3 188 ? 191.765 278.528 358.961 1.00 21.79 ? 188 GLY C C   1 
ATOM   5080 O O   . GLY C 3 188 ? 192.468 278.836 359.929 1.00 22.15 ? 188 GLY C O   1 
ATOM   5081 N N   . TYR C 3 189 ? 190.963 277.468 358.956 1.00 17.73 ? 189 TYR C N   1 
ATOM   5082 C CA  . TYR C 3 189 ? 190.716 276.673 360.150 1.00 16.00 ? 189 TYR C CA  1 
ATOM   5083 C C   . TYR C 3 189 ? 190.833 275.190 359.838 1.00 19.14 ? 189 TYR C C   1 
ATOM   5084 O O   . TYR C 3 189 ? 190.353 274.725 358.805 1.00 20.00 ? 189 TYR C O   1 
ATOM   5085 C CB  . TYR C 3 189 ? 189.332 276.973 360.717 1.00 12.59 ? 189 TYR C CB  1 
ATOM   5086 C CG  . TYR C 3 189 ? 189.087 278.440 360.967 1.00 23.26 ? 189 TYR C CG  1 
ATOM   5087 C CD1 . TYR C 3 189 ? 189.613 279.073 362.085 1.00 23.52 ? 189 TYR C CD1 1 
ATOM   5088 C CD2 . TYR C 3 189 ? 188.335 279.196 360.081 1.00 21.06 ? 189 TYR C CD2 1 
ATOM   5089 C CE1 . TYR C 3 189 ? 189.394 280.413 362.314 1.00 17.45 ? 189 TYR C CE1 1 
ATOM   5090 C CE2 . TYR C 3 189 ? 188.111 280.535 360.301 1.00 19.23 ? 189 TYR C CE2 1 
ATOM   5091 C CZ  . TYR C 3 189 ? 188.642 281.139 361.419 1.00 19.70 ? 189 TYR C CZ  1 
ATOM   5092 O OH  . TYR C 3 189 ? 188.417 282.476 361.636 1.00 27.48 ? 189 TYR C OH  1 
ATOM   5093 N N   . ILE C 3 190 ? 191.474 274.454 360.740 1.00 20.40 ? 190 ILE C N   1 
ATOM   5094 C CA  . ILE C 3 190 ? 191.545 272.999 360.698 1.00 14.98 ? 190 ILE C CA  1 
ATOM   5095 C C   . ILE C 3 190 ? 190.731 272.475 361.870 1.00 12.98 ? 190 ILE C C   1 
ATOM   5096 O O   . ILE C 3 190 ? 190.882 272.954 362.996 1.00 17.33 ? 190 ILE C O   1 
ATOM   5097 C CB  . ILE C 3 190 ? 192.997 272.495 360.771 1.00 21.63 ? 190 ILE C CB  1 
ATOM   5098 C CG1 . ILE C 3 190 ? 193.829 273.056 359.615 1.00 24.27 ? 190 ILE C CG1 1 
ATOM   5099 C CG2 . ILE C 3 190 ? 193.035 270.977 360.762 1.00 18.97 ? 190 ILE C CG2 1 
ATOM   5100 C CD1 . ILE C 3 190 ? 193.487 272.474 358.269 1.00 25.69 ? 190 ILE C CD1 1 
ATOM   5101 N N   . SER C 3 191 ? 189.855 271.512 361.608 1.00 17.36 ? 191 SER C N   1 
ATOM   5102 C CA  . SER C 3 191 ? 188.985 270.992 362.651 1.00 17.33 ? 191 SER C CA  1 
ATOM   5103 C C   . SER C 3 191 ? 188.868 269.483 362.518 1.00 20.99 ? 191 SER C C   1 
ATOM   5104 O O   . SER C 3 191 ? 189.006 268.920 361.430 1.00 20.10 ? 191 SER C O   1 
ATOM   5105 C CB  . SER C 3 191 ? 187.593 271.630 362.597 1.00 17.02 ? 191 SER C CB  1 
ATOM   5106 O OG  . SER C 3 191 ? 187.584 272.757 361.743 1.00 30.18 ? 191 SER C OG  1 
ATOM   5107 N N   . MET C 3 192 ? 188.613 268.833 363.652 1.00 20.00 ? 192 MET C N   1 
ATOM   5108 C CA  . MET C 3 192 ? 188.384 267.393 363.673 1.00 20.87 ? 192 MET C CA  1 
ATOM   5109 C C   . MET C 3 192 ? 187.072 267.084 364.379 1.00 12.47 ? 192 MET C C   1 
ATOM   5110 O O   . MET C 3 192 ? 186.750 267.689 365.403 1.00 19.14 ? 192 MET C O   1 
ATOM   5111 C CB  . MET C 3 192 ? 189.534 266.651 364.361 1.00 16.40 ? 192 MET C CB  1 
ATOM   5112 C CG  . MET C 3 192 ? 189.459 265.143 364.206 1.00 19.84 ? 192 MET C CG  1 
ATOM   5113 S SD  . MET C 3 192 ? 190.800 264.253 365.012 1.00 36.20 ? 192 MET C SD  1 
ATOM   5114 C CE  . MET C 3 192 ? 192.113 264.468 363.823 1.00 22.21 ? 192 MET C CE  1 
ATOM   5115 N N   . PHE C 3 193 ? 186.325 266.130 363.826 1.00 15.07 ? 193 PHE C N   1 
ATOM   5116 C CA  . PHE C 3 193 ? 185.015 265.754 364.339 1.00 22.26 ? 193 PHE C CA  1 
ATOM   5117 C C   . PHE C 3 193 ? 184.871 264.241 364.303 1.00 13.71 ? 193 PHE C C   1 
ATOM   5118 O O   . PHE C 3 193 ? 185.584 263.546 363.579 1.00 17.90 ? 193 PHE C O   1 
ATOM   5119 C CB  . PHE C 3 193 ? 183.875 266.390 363.525 1.00 16.45 ? 193 PHE C CB  1 
ATOM   5120 C CG  . PHE C 3 193 ? 183.791 267.877 363.663 1.00 18.23 ? 193 PHE C CG  1 
ATOM   5121 C CD1 . PHE C 3 193 ? 183.038 268.448 364.669 1.00 18.31 ? 193 PHE C CD1 1 
ATOM   5122 C CD2 . PHE C 3 193 ? 184.473 268.706 362.792 1.00 16.66 ? 193 PHE C CD2 1 
ATOM   5123 C CE1 . PHE C 3 193 ? 182.965 269.813 364.801 1.00 18.88 ? 193 PHE C CE1 1 
ATOM   5124 C CE2 . PHE C 3 193 ? 184.404 270.070 362.923 1.00 17.53 ? 193 PHE C CE2 1 
ATOM   5125 C CZ  . PHE C 3 193 ? 183.648 270.625 363.925 1.00 22.14 ? 193 PHE C CZ  1 
ATOM   5126 N N   . TYR C 3 194 ? 183.925 263.737 365.088 1.00 13.54 ? 194 TYR C N   1 
ATOM   5127 C CA  . TYR C 3 194 ? 183.508 262.346 364.979 1.00 16.46 ? 194 TYR C CA  1 
ATOM   5128 C C   . TYR C 3 194 ? 182.535 262.200 363.816 1.00 18.71 ? 194 TYR C C   1 
ATOM   5129 O O   . TYR C 3 194 ? 181.457 262.801 363.825 1.00 21.66 ? 194 TYR C O   1 
ATOM   5130 C CB  . TYR C 3 194 ? 182.851 261.873 366.272 1.00 19.53 ? 194 TYR C CB  1 
ATOM   5131 C CG  . TYR C 3 194 ? 183.798 261.700 367.431 1.00 14.01 ? 194 TYR C CG  1 
ATOM   5132 C CD1 . TYR C 3 194 ? 184.629 260.593 367.512 1.00 17.54 ? 194 TYR C CD1 1 
ATOM   5133 C CD2 . TYR C 3 194 ? 183.846 262.632 368.456 1.00 16.48 ? 194 TYR C CD2 1 
ATOM   5134 C CE1 . TYR C 3 194 ? 185.491 260.427 368.571 1.00 20.27 ? 194 TYR C CE1 1 
ATOM   5135 C CE2 . TYR C 3 194 ? 184.702 262.476 369.518 1.00 13.75 ? 194 TYR C CE2 1 
ATOM   5136 C CZ  . TYR C 3 194 ? 185.523 261.371 369.573 1.00 22.85 ? 194 TYR C CZ  1 
ATOM   5137 O OH  . TYR C 3 194 ? 186.377 261.211 370.634 1.00 26.10 ? 194 TYR C OH  1 
ATOM   5138 N N   . GLN C 3 195 ? 182.921 261.423 362.805 1.00 21.37 ? 195 GLN C N   1 
ATOM   5139 C CA  . GLN C 3 195 ? 181.978 261.063 361.752 1.00 17.01 ? 195 GLN C CA  1 
ATOM   5140 C C   . GLN C 3 195 ? 181.002 260.003 362.250 1.00 13.81 ? 195 GLN C C   1 
ATOM   5141 O O   . GLN C 3 195 ? 179.782 260.173 362.165 1.00 21.41 ? 195 GLN C O   1 
ATOM   5142 C CB  . GLN C 3 195 ? 182.741 260.576 360.521 1.00 13.83 ? 195 GLN C CB  1 
ATOM   5143 C CG  . GLN C 3 195 ? 181.870 260.246 359.323 1.00 22.78 ? 195 GLN C CG  1 
ATOM   5144 C CD  . GLN C 3 195 ? 181.300 261.476 358.642 1.00 20.67 ? 195 GLN C CD  1 
ATOM   5145 O OE1 . GLN C 3 195 ? 181.027 262.488 359.281 1.00 16.37 ? 195 GLN C OE1 1 
ATOM   5146 N NE2 . GLN C 3 195 ? 181.127 261.392 357.333 1.00 17.86 ? 195 GLN C NE2 1 
ATOM   5147 N N   . THR C 3 196 ? 181.533 258.901 362.784 1.00 21.75 ? 196 THR C N   1 
ATOM   5148 C CA  . THR C 3 196 ? 180.774 257.999 363.641 1.00 17.52 ? 196 THR C CA  1 
ATOM   5149 C C   . THR C 3 196 ? 181.467 258.086 364.991 1.00 22.22 ? 196 THR C C   1 
ATOM   5150 O O   . THR C 3 196 ? 182.392 258.879 365.135 1.00 37.71 ? 196 THR C O   1 
ATOM   5151 C CB  . THR C 3 196 ? 180.696 256.597 363.046 1.00 19.47 ? 196 THR C CB  1 
ATOM   5152 O OG1 . THR C 3 196 ? 181.993 255.993 363.052 1.00 22.28 ? 196 THR C OG1 1 
ATOM   5153 C CG2 . THR C 3 196 ? 180.171 256.637 361.618 1.00 17.13 ? 196 THR C CG2 1 
ATOM   5154 N N   . ARG C 3 197 ? 181.069 257.290 365.974 1.00 18.27 ? 197 ARG C N   1 
ATOM   5155 C CA  . ARG C 3 197 ? 181.759 257.291 367.254 1.00 18.51 ? 197 ARG C CA  1 
ATOM   5156 C C   . ARG C 3 197 ? 182.843 256.225 367.220 1.00 18.15 ? 197 ARG C C   1 
ATOM   5157 O O   . ARG C 3 197 ? 182.930 255.425 366.286 1.00 19.18 ? 197 ARG C O   1 
ATOM   5158 C CB  . ARG C 3 197 ? 180.799 257.054 368.424 1.00 16.53 ? 197 ARG C CB  1 
ATOM   5159 C CG  . ARG C 3 197 ? 180.317 255.631 368.571 1.00 14.15 ? 197 ARG C CG  1 
ATOM   5160 C CD  . ARG C 3 197 ? 179.348 255.512 369.730 1.00 18.00 ? 197 ARG C CD  1 
ATOM   5161 N NE  . ARG C 3 197 ? 178.803 254.167 369.862 1.00 24.77 ? 197 ARG C NE  1 
ATOM   5162 C CZ  . ARG C 3 197 ? 179.375 253.185 370.545 1.00 18.27 ? 197 ARG C CZ  1 
ATOM   5163 N NH1 . ARG C 3 197 ? 180.535 253.350 371.156 1.00 19.98 ? 197 ARG C NH1 1 
ATOM   5164 N NH2 . ARG C 3 197 ? 178.764 252.006 370.618 1.00 17.44 ? 197 ARG C NH2 1 
ATOM   5165 N N   . VAL C 3 198 ? 183.687 256.235 368.241 1.00 20.09 ? 198 VAL C N   1 
ATOM   5166 C CA  . VAL C 3 198 ? 184.687 255.193 368.432 1.00 17.24 ? 198 VAL C CA  1 
ATOM   5167 C C   . VAL C 3 198 ? 184.038 254.049 369.195 1.00 16.32 ? 198 VAL C C   1 
ATOM   5168 O O   . VAL C 3 198 ? 183.410 254.264 370.237 1.00 21.33 ? 198 VAL C O   1 
ATOM   5169 C CB  . VAL C 3 198 ? 185.918 255.736 369.177 1.00 20.84 ? 198 VAL C CB  1 
ATOM   5170 C CG1 . VAL C 3 198 ? 186.789 254.599 369.676 1.00 20.48 ? 198 VAL C CG1 1 
ATOM   5171 C CG2 . VAL C 3 198 ? 186.718 256.664 368.274 1.00 18.93 ? 198 VAL C CG2 1 
ATOM   5172 N N   . VAL C 3 199 ? 184.174 252.835 368.671 1.00 15.29 ? 199 VAL C N   1 
ATOM   5173 C CA  . VAL C 3 199 ? 183.540 251.651 369.238 1.00 21.54 ? 199 VAL C CA  1 
ATOM   5174 C C   . VAL C 3 199 ? 184.629 250.673 369.652 1.00 17.97 ? 199 VAL C C   1 
ATOM   5175 O O   . VAL C 3 199 ? 185.556 250.405 368.880 1.00 23.52 ? 199 VAL C O   1 
ATOM   5176 C CB  . VAL C 3 199 ? 182.566 250.993 368.242 1.00 17.70 ? 199 VAL C CB  1 
ATOM   5177 C CG1 . VAL C 3 199 ? 181.860 249.817 368.891 1.00 13.80 ? 199 VAL C CG1 1 
ATOM   5178 C CG2 . VAL C 3 199 ? 181.555 252.003 367.731 1.00 14.57 ? 199 VAL C CG2 1 
ATOM   5179 N N   . VAL C 3 200 ? 184.517 250.146 370.866 1.00 14.86 ? 200 VAL C N   1 
ATOM   5180 C CA  . VAL C 3 200 ? 185.431 249.115 371.349 1.00 19.06 ? 200 VAL C CA  1 
ATOM   5181 C C   . VAL C 3 200 ? 184.623 247.951 371.909 1.00 17.68 ? 200 VAL C C   1 
ATOM   5182 O O   . VAL C 3 200 ? 183.508 248.154 372.409 1.00 19.92 ? 200 VAL C O   1 
ATOM   5183 C CB  . VAL C 3 200 ? 186.401 249.664 372.409 1.00 18.44 ? 200 VAL C CB  1 
ATOM   5184 C CG1 . VAL C 3 200 ? 187.403 250.619 371.780 1.00 20.34 ? 200 VAL C CG1 1 
ATOM   5185 C CG2 . VAL C 3 200 ? 185.642 250.342 373.540 1.00 17.44 ? 200 VAL C CG2 1 
ATOM   5186 N N   . PRO C 3 201 ? 185.138 246.723 371.849 1.00 19.64 ? 201 PRO C N   1 
ATOM   5187 C CA  . PRO C 3 201 ? 184.481 245.613 372.548 1.00 13.65 ? 201 PRO C CA  1 
ATOM   5188 C C   . PRO C 3 201 ? 184.771 245.643 374.040 1.00 19.23 ? 201 PRO C C   1 
ATOM   5189 O O   . PRO C 3 201 ? 185.357 246.605 374.542 1.00 27.68 ? 201 PRO C O   1 
ATOM   5190 C CB  . PRO C 3 201 ? 185.079 244.377 371.870 1.00 13.34 ? 201 PRO C CB  1 
ATOM   5191 C CG  . PRO C 3 201 ? 186.428 244.818 371.441 1.00 18.55 ? 201 PRO C CG  1 
ATOM   5192 C CD  . PRO C 3 201 ? 186.308 246.270 371.078 1.00 19.13 ? 201 PRO C CD  1 
ATOM   5193 N N   . LEU C 3 202 ? 184.352 244.610 374.760 1.00 22.69 ? 202 LEU C N   1 
ATOM   5194 C CA  . LEU C 3 202 ? 184.666 244.511 376.175 1.00 20.86 ? 202 LEU C CA  1 
ATOM   5195 C C   . LEU C 3 202 ? 186.144 244.186 376.376 1.00 21.26 ? 202 LEU C C   1 
ATOM   5196 O O   . LEU C 3 202 ? 186.834 243.715 375.468 1.00 24.65 ? 202 LEU C O   1 
ATOM   5197 C CB  . LEU C 3 202 ? 183.803 243.444 376.846 1.00 21.16 ? 202 LEU C CB  1 
ATOM   5198 C CG  . LEU C 3 202 ? 182.287 243.654 376.816 1.00 22.55 ? 202 LEU C CG  1 
ATOM   5199 C CD1 . LEU C 3 202 ? 181.594 242.600 377.655 1.00 16.68 ? 202 LEU C CD1 1 
ATOM   5200 C CD2 . LEU C 3 202 ? 181.917 245.050 377.291 1.00 17.52 ? 202 LEU C CD2 1 
ATOM   5201 N N   . SER C 3 203 ? 186.627 244.448 377.590 1.00 27.00 ? 203 SER C N   1 
ATOM   5202 C CA  . SER C 3 203 ? 188.018 244.179 377.958 1.00 17.60 ? 203 SER C CA  1 
ATOM   5203 C C   . SER C 3 203 ? 188.986 244.927 377.044 1.00 19.69 ? 203 SER C C   1 
ATOM   5204 O O   . SER C 3 203 ? 190.048 244.419 376.684 1.00 26.26 ? 203 SER C O   1 
ATOM   5205 C CB  . SER C 3 203 ? 188.311 242.676 377.938 1.00 18.84 ? 203 SER C CB  1 
ATOM   5206 O OG  . SER C 3 203 ? 187.508 241.981 378.872 1.00 27.54 ? 203 SER C OG  1 
ATOM   5207 N N   . THR C 3 204 ? 188.616 246.149 376.670 1.00 21.94 ? 204 THR C N   1 
ATOM   5208 C CA  . THR C 3 204 ? 189.426 247.001 375.820 1.00 13.93 ? 204 THR C CA  1 
ATOM   5209 C C   . THR C 3 204 ? 189.483 248.395 376.430 1.00 22.45 ? 204 THR C C   1 
ATOM   5210 O O   . THR C 3 204 ? 188.498 248.843 377.027 1.00 25.16 ? 204 THR C O   1 
ATOM   5211 C CB  . THR C 3 204 ? 188.838 247.080 374.401 1.00 20.25 ? 204 THR C CB  1 
ATOM   5212 O OG1 . THR C 3 204 ? 188.501 245.766 373.947 1.00 25.37 ? 204 THR C OG1 1 
ATOM   5213 C CG2 . THR C 3 204 ? 189.825 247.698 373.435 1.00 21.08 ? 204 THR C CG2 1 
ATOM   5214 N N   . PRO C 3 205 ? 190.606 249.102 376.312 1.00 24.29 ? 205 PRO C N   1 
ATOM   5215 C CA  . PRO C 3 205 ? 190.635 250.494 376.780 1.00 20.08 ? 205 PRO C CA  1 
ATOM   5216 C C   . PRO C 3 205 ? 189.602 251.335 376.046 1.00 20.40 ? 205 PRO C C   1 
ATOM   5217 O O   . PRO C 3 205 ? 189.464 251.253 374.824 1.00 21.22 ? 205 PRO C O   1 
ATOM   5218 C CB  . PRO C 3 205 ? 192.065 250.944 376.467 1.00 15.90 ? 205 PRO C CB  1 
ATOM   5219 C CG  . PRO C 3 205 ? 192.851 249.692 376.392 1.00 14.68 ? 205 PRO C CG  1 
ATOM   5220 C CD  . PRO C 3 205 ? 191.927 248.662 375.833 1.00 18.24 ? 205 PRO C CD  1 
ATOM   5221 N N   . ARG C 3 206 ? 188.878 252.156 376.804 1.00 24.90 ? 206 ARG C N   1 
ATOM   5222 C CA  . ARG C 3 206 ? 187.839 253.003 376.237 1.00 20.48 ? 206 ARG C CA  1 
ATOM   5223 C C   . ARG C 3 206 ? 188.334 254.401 375.893 1.00 24.93 ? 206 ARG C C   1 
ATOM   5224 O O   . ARG C 3 206 ? 187.662 255.112 375.141 1.00 26.28 ? 206 ARG C O   1 
ATOM   5225 C CB  . ARG C 3 206 ? 186.661 253.104 377.206 1.00 20.88 ? 206 ARG C CB  1 
ATOM   5226 C CG  . ARG C 3 206 ? 185.885 251.812 377.367 1.00 24.25 ? 206 ARG C CG  1 
ATOM   5227 C CD  . ARG C 3 206 ? 184.861 251.930 378.474 1.00 22.51 ? 206 ARG C CD  1 
ATOM   5228 N NE  . ARG C 3 206 ? 183.983 253.076 378.276 1.00 30.90 ? 206 ARG C NE  1 
ATOM   5229 C CZ  . ARG C 3 206 ? 183.230 253.620 379.222 1.00 31.46 ? 206 ARG C CZ  1 
ATOM   5230 N NH1 . ARG C 3 206 ? 183.220 253.146 380.458 1.00 31.38 ? 206 ARG C NH1 1 
ATOM   5231 N NH2 . ARG C 3 206 ? 182.471 254.668 378.922 1.00 31.43 ? 206 ARG C NH2 1 
ATOM   5232 N N   . LYS C 3 207 ? 189.480 254.807 376.424 1.00 26.88 ? 207 LYS C N   1 
ATOM   5233 C CA  . LYS C 3 207 ? 190.127 256.056 376.059 1.00 23.55 ? 207 LYS C CA  1 
ATOM   5234 C C   . LYS C 3 207 ? 191.443 255.756 375.356 1.00 21.03 ? 207 LYS C C   1 
ATOM   5235 O O   . LYS C 3 207 ? 192.153 254.814 375.711 1.00 29.09 ? 207 LYS C O   1 
ATOM   5236 C CB  . LYS C 3 207 ? 190.374 256.927 377.291 1.00 21.89 ? 207 LYS C CB  1 
ATOM   5237 C CG  . LYS C 3 207 ? 189.107 257.460 377.923 1.00 26.63 ? 207 LYS C CG  1 
ATOM   5238 C CD  . LYS C 3 207 ? 189.371 258.069 379.281 1.00 31.80 ? 207 LYS C CD  1 
ATOM   5239 C CE  . LYS C 3 207 ? 188.119 258.725 379.843 1.00 30.77 ? 207 LYS C CE  1 
ATOM   5240 N NZ  . LYS C 3 207 ? 188.308 259.180 381.249 1.00 33.84 ? 207 LYS C NZ  1 
ATOM   5241 N N   . MET C 3 208 ? 191.755 256.558 374.344 1.00 18.38 ? 208 MET C N   1 
ATOM   5242 C CA  . MET C 3 208 ? 192.986 256.379 373.587 1.00 17.28 ? 208 MET C CA  1 
ATOM   5243 C C   . MET C 3 208 ? 193.462 257.745 373.119 1.00 23.51 ? 208 MET C C   1 
ATOM   5244 O O   . MET C 3 208 ? 192.781 258.752 373.296 1.00 23.68 ? 208 MET C O   1 
ATOM   5245 C CB  . MET C 3 208 ? 192.792 255.425 372.404 1.00 17.79 ? 208 MET C CB  1 
ATOM   5246 C CG  . MET C 3 208 ? 191.528 255.662 371.606 1.00 20.31 ? 208 MET C CG  1 
ATOM   5247 S SD  . MET C 3 208 ? 190.224 254.490 372.020 1.00 33.43 ? 208 MET C SD  1 
ATOM   5248 C CE  . MET C 3 208 ? 188.858 255.608 372.288 1.00 27.10 ? 208 MET C CE  1 
ATOM   5249 N N   . ASP C 3 209 ? 194.649 257.767 372.526 1.00 22.29 ? 209 ASP C N   1 
ATOM   5250 C CA  . ASP C 3 209 ? 195.286 259.004 372.109 1.00 17.66 ? 209 ASP C CA  1 
ATOM   5251 C C   . ASP C 3 209 ? 195.512 259.016 370.605 1.00 21.72 ? 209 ASP C C   1 
ATOM   5252 O O   . ASP C 3 209 ? 195.768 257.981 369.986 1.00 24.75 ? 209 ASP C O   1 
ATOM   5253 C CB  . ASP C 3 209 ? 196.625 259.200 372.824 1.00 22.61 ? 209 ASP C CB  1 
ATOM   5254 C CG  . ASP C 3 209 ? 196.461 259.663 374.254 1.00 24.70 ? 209 ASP C CG  1 
ATOM   5255 O OD1 . ASP C 3 209 ? 195.687 260.613 374.489 1.00 23.95 ? 209 ASP C OD1 1 
ATOM   5256 O OD2 . ASP C 3 209 ? 197.105 259.078 375.146 1.00 21.47 ? 209 ASP C OD2 1 
ATOM   5257 N N   . ILE C 3 210 ? 195.411 260.210 370.028 1.00 25.37 ? 210 ILE C N   1 
ATOM   5258 C CA  . ILE C 3 210 ? 195.883 260.480 368.681 1.00 20.19 ? 210 ILE C CA  1 
ATOM   5259 C C   . ILE C 3 210 ? 197.003 261.506 368.775 1.00 15.45 ? 210 ILE C C   1 
ATOM   5260 O O   . ILE C 3 210 ? 197.083 262.301 369.718 1.00 18.48 ? 210 ILE C O   1 
ATOM   5261 C CB  . ILE C 3 210 ? 194.767 260.977 367.736 1.00 19.05 ? 210 ILE C CB  1 
ATOM   5262 C CG1 . ILE C 3 210 ? 194.161 262.283 368.251 1.00 23.06 ? 210 ILE C CG1 1 
ATOM   5263 C CG2 . ILE C 3 210 ? 193.691 259.917 367.569 1.00 21.57 ? 210 ILE C CG2 1 
ATOM   5264 C CD1 . ILE C 3 210 ? 193.166 262.900 367.304 1.00 21.14 ? 210 ILE C CD1 1 
ATOM   5265 N N   . LEU C 3 211 ? 197.875 261.469 367.773 1.00 15.11 ? 211 LEU C N   1 
ATOM   5266 C CA  . LEU C 3 211 ? 199.006 262.376 367.661 1.00 11.69 ? 211 LEU C CA  1 
ATOM   5267 C C   . LEU C 3 211 ? 198.950 263.079 366.314 1.00 18.06 ? 211 LEU C C   1 
ATOM   5268 O O   . LEU C 3 211 ? 198.507 262.506 365.317 1.00 19.48 ? 211 LEU C O   1 
ATOM   5269 C CB  . LEU C 3 211 ? 200.344 261.634 367.800 1.00 13.43 ? 211 LEU C CB  1 
ATOM   5270 C CG  . LEU C 3 211 ? 200.534 260.784 369.058 1.00 18.57 ? 211 LEU C CG  1 
ATOM   5271 C CD1 . LEU C 3 211 ? 201.860 260.055 369.010 1.00 15.35 ? 211 LEU C CD1 1 
ATOM   5272 C CD2 . LEU C 3 211 ? 200.442 261.639 370.307 1.00 17.07 ? 211 LEU C CD2 1 
ATOM   5273 N N   . GLY C 3 212 ? 199.412 264.321 366.292 1.00 17.76 ? 212 GLY C N   1 
ATOM   5274 C CA  . GLY C 3 212 ? 199.401 265.134 365.085 1.00 7.66  ? 212 GLY C CA  1 
ATOM   5275 C C   . GLY C 3 212 ? 200.802 265.511 364.646 1.00 18.74 ? 212 GLY C C   1 
ATOM   5276 O O   . GLY C 3 212 ? 201.647 265.857 365.471 1.00 23.94 ? 212 GLY C O   1 
ATOM   5277 N N   . PHE C 3 213 ? 201.033 265.446 363.339 1.00 19.21 ? 213 PHE C N   1 
ATOM   5278 C CA  . PHE C 3 213 ? 202.287 265.833 362.716 1.00 15.28 ? 213 PHE C CA  1 
ATOM   5279 C C   . PHE C 3 213 ? 201.983 266.806 361.589 1.00 9.73  ? 213 PHE C C   1 
ATOM   5280 O O   . PHE C 3 213 ? 200.948 266.695 360.930 1.00 19.37 ? 213 PHE C O   1 
ATOM   5281 C CB  . PHE C 3 213 ? 203.043 264.622 362.149 1.00 13.69 ? 213 PHE C CB  1 
ATOM   5282 C CG  . PHE C 3 213 ? 203.408 263.592 363.173 1.00 13.82 ? 213 PHE C CG  1 
ATOM   5283 C CD1 . PHE C 3 213 ? 202.464 262.691 363.638 1.00 13.09 ? 213 PHE C CD1 1 
ATOM   5284 C CD2 . PHE C 3 213 ? 204.702 263.508 363.656 1.00 19.22 ? 213 PHE C CD2 1 
ATOM   5285 C CE1 . PHE C 3 213 ? 202.800 261.744 364.575 1.00 14.12 ? 213 PHE C CE1 1 
ATOM   5286 C CE2 . PHE C 3 213 ? 205.043 262.560 364.594 1.00 11.93 ? 213 PHE C CE2 1 
ATOM   5287 C CZ  . PHE C 3 213 ? 204.093 261.675 365.050 1.00 11.99 ? 213 PHE C CZ  1 
ATOM   5288 N N   . VAL C 3 214 ? 202.886 267.751 361.361 1.00 15.62 ? 214 VAL C N   1 
ATOM   5289 C CA  . VAL C 3 214 ? 202.724 268.722 360.289 1.00 15.40 ? 214 VAL C CA  1 
ATOM   5290 C C   . VAL C 3 214 ? 204.033 268.843 359.527 1.00 9.03  ? 214 VAL C C   1 
ATOM   5291 O O   . VAL C 3 214 ? 205.122 268.736 360.098 1.00 18.91 ? 214 VAL C O   1 
ATOM   5292 C CB  . VAL C 3 214 ? 202.270 270.102 360.819 1.00 15.35 ? 214 VAL C CB  1 
ATOM   5293 C CG1 . VAL C 3 214 ? 203.386 270.778 361.597 1.00 9.20  ? 214 VAL C CG1 1 
ATOM   5294 C CG2 . VAL C 3 214 ? 201.797 270.978 359.675 1.00 14.29 ? 214 VAL C CG2 1 
ATOM   5295 N N   . SER C 3 215 ? 203.919 269.054 358.220 1.00 7.24  ? 215 SER C N   1 
ATOM   5296 C CA  . SER C 3 215 ? 205.088 269.354 357.405 1.00 17.79 ? 215 SER C CA  1 
ATOM   5297 C C   . SER C 3 215 ? 204.657 270.187 356.209 1.00 16.96 ? 215 SER C C   1 
ATOM   5298 O O   . SER C 3 215 ? 203.468 270.396 355.970 1.00 20.28 ? 215 SER C O   1 
ATOM   5299 C CB  . SER C 3 215 ? 205.811 268.083 356.944 1.00 13.62 ? 215 SER C CB  1 
ATOM   5300 O OG  . SER C 3 215 ? 204.984 267.270 356.135 1.00 24.41 ? 215 SER C OG  1 
ATOM   5301 N N   . ALA C 3 216 ? 205.647 270.680 355.477 1.00 16.69 ? 216 ALA C N   1 
ATOM   5302 C CA  . ALA C 3 216 ? 205.410 271.436 354.259 1.00 11.17 ? 216 ALA C CA  1 
ATOM   5303 C C   . ALA C 3 216 ? 205.490 270.521 353.047 1.00 18.96 ? 216 ALA C C   1 
ATOM   5304 O O   . ALA C 3 216 ? 206.191 269.507 353.055 1.00 22.21 ? 216 ALA C O   1 
ATOM   5305 C CB  . ALA C 3 216 ? 206.425 272.569 354.123 1.00 9.32  ? 216 ALA C CB  1 
ATOM   5306 N N   . CYS C 3 217 ? 204.757 270.886 352.000 1.00 22.86 ? 217 CYS C N   1 
ATOM   5307 C CA  . CYS C 3 217 ? 204.789 270.148 350.750 1.00 17.31 ? 217 CYS C CA  1 
ATOM   5308 C C   . CYS C 3 217 ? 205.907 270.687 349.858 1.00 19.09 ? 217 CYS C C   1 
ATOM   5309 O O   . CYS C 3 217 ? 206.588 271.659 350.190 1.00 24.49 ? 217 CYS C O   1 
ATOM   5310 C CB  . CYS C 3 217 ? 203.431 270.221 350.053 1.00 21.65 ? 217 CYS C CB  1 
ATOM   5311 S SG  . CYS C 3 217 ? 202.095 269.393 350.942 1.00 42.10 ? 217 CYS C SG  1 
ATOM   5312 N N   . ASN C 3 218 ? 206.100 270.049 348.705 1.00 21.84 ? 218 ASN C N   1 
ATOM   5313 C CA  . ASN C 3 218 ? 207.221 270.382 347.834 1.00 21.16 ? 218 ASN C CA  1 
ATOM   5314 C C   . ASN C 3 218 ? 207.072 271.737 347.154 1.00 22.69 ? 218 ASN C C   1 
ATOM   5315 O O   . ASN C 3 218 ? 208.048 272.229 346.582 1.00 27.48 ? 218 ASN C O   1 
ATOM   5316 C CB  . ASN C 3 218 ? 207.399 269.298 346.769 1.00 22.87 ? 218 ASN C CB  1 
ATOM   5317 C CG  . ASN C 3 218 ? 208.815 269.243 346.227 1.00 33.34 ? 218 ASN C CG  1 
ATOM   5318 O OD1 . ASN C 3 218 ? 209.783 269.245 346.988 1.00 31.01 ? 218 ASN C OD1 1 
ATOM   5319 N ND2 . ASN C 3 218 ? 208.944 269.211 344.906 1.00 34.39 ? 218 ASN C ND2 1 
ATOM   5320 N N   . ASP C 3 219 ? 205.891 272.347 347.196 1.00 22.68 ? 219 ASP C N   1 
ATOM   5321 C CA  . ASP C 3 219 ? 205.662 273.656 346.599 1.00 14.38 ? 219 ASP C CA  1 
ATOM   5322 C C   . ASP C 3 219 ? 205.866 274.797 347.590 1.00 15.68 ? 219 ASP C C   1 
ATOM   5323 O O   . ASP C 3 219 ? 205.570 275.949 347.260 1.00 26.93 ? 219 ASP C O   1 
ATOM   5324 C CB  . ASP C 3 219 ? 204.247 273.722 346.017 1.00 17.98 ? 219 ASP C CB  1 
ATOM   5325 C CG  . ASP C 3 219 ? 203.176 273.727 347.088 1.00 21.98 ? 219 ASP C CG  1 
ATOM   5326 O OD1 . ASP C 3 219 ? 203.464 273.289 348.220 1.00 24.43 ? 219 ASP C OD1 1 
ATOM   5327 O OD2 . ASP C 3 219 ? 202.047 274.174 346.802 1.00 18.24 ? 219 ASP C OD2 1 
ATOM   5328 N N   . PHE C 3 220 ? 206.353 274.501 348.790 1.00 13.43 ? 220 PHE C N   1 
ATOM   5329 C CA  . PHE C 3 220 ? 206.508 275.500 349.837 1.00 13.63 ? 220 PHE C CA  1 
ATOM   5330 C C   . PHE C 3 220 ? 207.730 276.375 349.579 1.00 17.46 ? 220 PHE C C   1 
ATOM   5331 O O   . PHE C 3 220 ? 208.740 275.913 349.044 1.00 24.22 ? 220 PHE C O   1 
ATOM   5332 C CB  . PHE C 3 220 ? 206.635 274.801 351.189 1.00 7.94  ? 220 PHE C CB  1 
ATOM   5333 C CG  . PHE C 3 220 ? 206.138 275.608 352.344 1.00 12.21 ? 220 PHE C CG  1 
ATOM   5334 C CD1 . PHE C 3 220 ? 206.986 276.456 353.029 1.00 14.98 ? 220 PHE C CD1 1 
ATOM   5335 C CD2 . PHE C 3 220 ? 204.826 275.502 352.762 1.00 9.63  ? 220 PHE C CD2 1 
ATOM   5336 C CE1 . PHE C 3 220 ? 206.533 277.190 354.096 1.00 13.28 ? 220 PHE C CE1 1 
ATOM   5337 C CE2 . PHE C 3 220 ? 204.369 276.233 353.831 1.00 9.42  ? 220 PHE C CE2 1 
ATOM   5338 C CZ  . PHE C 3 220 ? 205.224 277.079 354.500 1.00 13.48 ? 220 PHE C CZ  1 
ATOM   5339 N N   . SER C 3 221 ? 207.630 277.649 349.957 1.00 12.28 ? 221 SER C N   1 
ATOM   5340 C CA  . SER C 3 221 ? 208.755 278.568 349.853 1.00 8.89  ? 221 SER C CA  1 
ATOM   5341 C C   . SER C 3 221 ? 208.593 279.689 350.871 1.00 10.11 ? 221 SER C C   1 
ATOM   5342 O O   . SER C 3 221 ? 207.493 279.967 351.355 1.00 16.20 ? 221 SER C O   1 
ATOM   5343 C CB  . SER C 3 221 ? 208.889 279.151 348.441 1.00 9.90  ? 221 SER C CB  1 
ATOM   5344 O OG  . SER C 3 221 ? 207.885 280.112 348.182 1.00 21.35 ? 221 SER C OG  1 
ATOM   5345 N N   . VAL C 3 222 ? 209.720 280.331 351.187 1.00 16.19 ? 222 VAL C N   1 
ATOM   5346 C CA  . VAL C 3 222 ? 209.789 281.401 352.172 1.00 10.06 ? 222 VAL C CA  1 
ATOM   5347 C C   . VAL C 3 222 ? 210.625 282.541 351.604 1.00 10.88 ? 222 VAL C C   1 
ATOM   5348 O O   . VAL C 3 222 ? 211.386 282.369 350.651 1.00 18.28 ? 222 VAL C O   1 
ATOM   5349 C CB  . VAL C 3 222 ? 210.377 280.918 353.516 1.00 7.80  ? 222 VAL C CB  1 
ATOM   5350 C CG1 . VAL C 3 222 ? 209.412 279.973 354.205 1.00 11.08 ? 222 VAL C CG1 1 
ATOM   5351 C CG2 . VAL C 3 222 ? 211.728 280.243 353.305 1.00 10.39 ? 222 VAL C CG2 1 
ATOM   5352 N N   . ARG C 3 223 ? 210.468 283.721 352.202 1.00 8.53  ? 223 ARG C N   1 
ATOM   5353 C CA  . ARG C 3 223 ? 211.177 284.906 351.738 1.00 1.16  ? 223 ARG C CA  1 
ATOM   5354 C C   . ARG C 3 223 ? 211.485 285.844 352.894 1.00 12.51 ? 223 ARG C C   1 
ATOM   5355 O O   . ARG C 3 223 ? 210.782 285.864 353.912 1.00 8.03  ? 223 ARG C O   1 
ATOM   5356 C CB  . ARG C 3 223 ? 210.386 285.699 350.689 1.00 8.07  ? 223 ARG C CB  1 
ATOM   5357 C CG  . ARG C 3 223 ? 209.968 284.930 349.460 1.00 9.06  ? 223 ARG C CG  1 
ATOM   5358 C CD  . ARG C 3 223 ? 209.489 285.872 348.372 1.00 7.97  ? 223 ARG C CD  1 
ATOM   5359 N NE  . ARG C 3 223 ? 208.550 286.869 348.875 1.00 16.36 ? 223 ARG C NE  1 
ATOM   5360 C CZ  . ARG C 3 223 ? 207.849 287.692 348.108 1.00 1.88  ? 223 ARG C CZ  1 
ATOM   5361 N NH1 . ARG C 3 223 ? 207.931 287.649 346.791 1.00 6.56  ? 223 ARG C NH1 1 
ATOM   5362 N NH2 . ARG C 3 223 ? 207.036 288.574 348.679 1.00 0.01  ? 223 ARG C NH2 1 
ATOM   5363 N N   . LEU C 3 224 ? 212.501 286.684 352.662 1.00 11.60 ? 224 LEU C N   1 
ATOM   5364 C CA  . LEU C 3 224 ? 212.920 287.771 353.542 1.00 6.94  ? 224 LEU C CA  1 
ATOM   5365 C C   . LEU C 3 224 ? 213.416 287.295 354.904 1.00 11.15 ? 224 LEU C C   1 
ATOM   5366 O O   . LEU C 3 224 ? 212.753 287.491 355.926 1.00 6.94  ? 224 LEU C O   1 
ATOM   5367 C CB  . LEU C 3 224 ? 211.782 288.779 353.699 1.00 15.05 ? 224 LEU C CB  1 
ATOM   5368 C CG  . LEU C 3 224 ? 212.090 290.070 354.465 1.00 18.62 ? 224 LEU C CG  1 
ATOM   5369 C CD1 . LEU C 3 224 ? 213.490 290.577 354.187 1.00 12.03 ? 224 LEU C CD1 1 
ATOM   5370 C CD2 . LEU C 3 224 ? 211.069 291.130 354.108 1.00 9.70  ? 224 LEU C CD2 1 
ATOM   5371 N N   . LEU C 3 225 ? 214.576 286.641 354.895 1.00 14.65 ? 225 LEU C N   1 
ATOM   5372 C CA  . LEU C 3 225 ? 215.258 286.222 356.114 1.00 10.35 ? 225 LEU C CA  1 
ATOM   5373 C C   . LEU C 3 225 ? 215.227 287.306 357.186 1.00 0.01  ? 225 LEU C C   1 
ATOM   5374 O O   . LEU C 3 225 ? 215.429 288.489 356.906 1.00 14.31 ? 225 LEU C O   1 
ATOM   5375 C CB  . LEU C 3 225 ? 216.707 285.861 355.781 1.00 9.20  ? 225 LEU C CB  1 
ATOM   5376 C CG  . LEU C 3 225 ? 217.619 285.402 356.918 1.00 12.28 ? 225 LEU C CG  1 
ATOM   5377 C CD1 . LEU C 3 225 ? 217.278 283.983 357.342 1.00 6.55  ? 225 LEU C CD1 1 
ATOM   5378 C CD2 . LEU C 3 225 ? 219.075 285.516 356.503 1.00 3.92  ? 225 LEU C CD2 1 
ATOM   5379 N N   . ARG C 3 226 ? 214.993 286.888 358.428 1.00 12.89 ? 226 ARG C N   1 
ATOM   5380 C CA  . ARG C 3 226 ? 214.880 287.804 359.554 1.00 10.48 ? 226 ARG C CA  1 
ATOM   5381 C C   . ARG C 3 226 ? 215.229 287.060 360.835 1.00 10.45 ? 226 ARG C C   1 
ATOM   5382 O O   . ARG C 3 226 ? 215.275 285.830 360.871 1.00 18.65 ? 226 ARG C O   1 
ATOM   5383 C CB  . ARG C 3 226 ? 213.471 288.398 359.660 1.00 9.56  ? 226 ARG C CB  1 
ATOM   5384 C CG  . ARG C 3 226 ? 212.370 287.367 359.869 1.00 9.53  ? 226 ARG C CG  1 
ATOM   5385 C CD  . ARG C 3 226 ? 211.138 287.994 360.479 1.00 15.00 ? 226 ARG C CD  1 
ATOM   5386 N NE  . ARG C 3 226 ? 210.110 287.012 360.802 1.00 10.84 ? 226 ARG C NE  1 
ATOM   5387 C CZ  . ARG C 3 226 ? 209.954 286.439 361.988 1.00 14.04 ? 226 ARG C CZ  1 
ATOM   5388 N NH1 . ARG C 3 226 ? 210.772 286.695 362.996 1.00 11.97 ? 226 ARG C NH1 1 
ATOM   5389 N NH2 . ARG C 3 226 ? 208.951 285.589 362.169 1.00 12.29 ? 226 ARG C NH2 1 
ATOM   5390 N N   . ASP C 3 227 ? 215.466 287.824 361.896 1.00 8.56  ? 227 ASP C N   1 
ATOM   5391 C CA  . ASP C 3 227 ? 215.763 287.245 363.196 1.00 7.26  ? 227 ASP C CA  1 
ATOM   5392 C C   . ASP C 3 227 ? 214.501 286.697 363.854 1.00 15.98 ? 227 ASP C C   1 
ATOM   5393 O O   . ASP C 3 227 ? 213.399 287.222 363.676 1.00 23.78 ? 227 ASP C O   1 
ATOM   5394 C CB  . ASP C 3 227 ? 216.420 288.282 364.107 1.00 7.39  ? 227 ASP C CB  1 
ATOM   5395 C CG  . ASP C 3 227 ? 217.919 288.386 363.886 1.00 15.93 ? 227 ASP C CG  1 
ATOM   5396 O OD1 . ASP C 3 227 ? 218.553 287.351 363.600 1.00 19.99 ? 227 ASP C OD1 1 
ATOM   5397 O OD2 . ASP C 3 227 ? 218.468 289.501 364.000 1.00 20.95 ? 227 ASP C OD2 1 
ATOM   5398 N N   . THR C 3 228 ? 214.677 285.627 364.621 1.00 11.78 ? 228 THR C N   1 
ATOM   5399 C CA  . THR C 3 228 ? 213.579 284.928 365.269 1.00 8.66  ? 228 THR C CA  1 
ATOM   5400 C C   . THR C 3 228 ? 213.295 285.512 366.649 1.00 11.68 ? 228 THR C C   1 
ATOM   5401 O O   . THR C 3 228 ? 214.145 286.150 367.272 1.00 21.79 ? 228 THR C O   1 
ATOM   5402 C CB  . THR C 3 228 ? 213.898 283.434 365.401 1.00 17.04 ? 228 THR C CB  1 
ATOM   5403 O OG1 . THR C 3 228 ? 212.715 282.715 365.769 1.00 22.02 ? 228 THR C OG1 1 
ATOM   5404 C CG2 . THR C 3 228 ? 214.969 283.203 366.460 1.00 12.62 ? 228 THR C CG2 1 
ATOM   5405 N N   . THR C 3 229 ? 212.078 285.272 367.128 1.00 17.77 ? 229 THR C N   1 
ATOM   5406 C CA  . THR C 3 229 ? 211.680 285.630 368.481 1.00 16.87 ? 229 THR C CA  1 
ATOM   5407 C C   . THR C 3 229 ? 211.784 284.464 369.455 1.00 19.76 ? 229 THR C C   1 
ATOM   5408 O O   . THR C 3 229 ? 211.424 284.621 370.624 1.00 25.63 ? 229 THR C O   1 
ATOM   5409 C CB  . THR C 3 229 ? 210.245 286.167 368.488 1.00 17.11 ? 229 THR C CB  1 
ATOM   5410 O OG1 . THR C 3 229 ? 209.386 285.246 367.805 1.00 25.26 ? 229 THR C OG1 1 
ATOM   5411 C CG2 . THR C 3 229 ? 210.173 287.524 367.812 1.00 14.32 ? 229 THR C CG2 1 
ATOM   5412 N N   . HIS C 3 230 ? 212.264 283.308 369.007 1.00 23.54 ? 230 HIS C N   1 
ATOM   5413 C CA  . HIS C 3 230 ? 212.307 282.107 369.831 1.00 17.04 ? 230 HIS C CA  1 
ATOM   5414 C C   . HIS C 3 230 ? 213.612 281.949 370.603 1.00 21.98 ? 230 HIS C C   1 
ATOM   5415 O O   . HIS C 3 230 ? 213.751 280.981 371.356 1.00 29.84 ? 230 HIS C O   1 
ATOM   5416 C CB  . HIS C 3 230 ? 212.077 280.870 368.958 1.00 15.96 ? 230 HIS C CB  1 
ATOM   5417 C CG  . HIS C 3 230 ? 210.701 280.790 368.371 1.00 22.27 ? 230 HIS C CG  1 
ATOM   5418 N ND1 . HIS C 3 230 ? 210.289 279.737 367.585 1.00 25.19 ? 230 HIS C ND1 1 
ATOM   5419 C CD2 . HIS C 3 230 ? 209.644 281.631 368.455 1.00 22.61 ? 230 HIS C CD2 1 
ATOM   5420 C CE1 . HIS C 3 230 ? 209.038 279.932 367.210 1.00 22.99 ? 230 HIS C CE1 1 
ATOM   5421 N NE2 . HIS C 3 230 ? 208.623 281.074 367.724 1.00 17.83 ? 230 HIS C NE2 1 
ATOM   5422 N N   . ILE C 3 231 ? 214.569 282.861 370.440 1.00 23.95 ? 231 ILE C N   1 
ATOM   5423 C CA  . ILE C 3 231 ? 215.813 282.832 371.198 1.00 24.34 ? 231 ILE C CA  1 
ATOM   5424 C C   . ILE C 3 231 ? 216.139 284.249 371.642 1.00 27.35 ? 231 ILE C C   1 
ATOM   5425 O O   . ILE C 3 231 ? 216.009 285.206 370.873 1.00 31.46 ? 231 ILE C O   1 
ATOM   5426 C CB  . ILE C 3 231 ? 216.980 282.234 370.378 1.00 25.15 ? 231 ILE C CB  1 
ATOM   5427 C CG1 . ILE C 3 231 ? 218.165 281.887 371.283 1.00 25.54 ? 231 ILE C CG1 1 
ATOM   5428 C CG2 . ILE C 3 231 ? 217.430 283.194 369.291 1.00 20.68 ? 231 ILE C CG2 1 
ATOM   5429 C CD1 . ILE C 3 231 ? 217.920 280.716 372.202 1.00 24.23 ? 231 ILE C CD1 1 
ATOM   5430 N N   . SER C 3 232 ? 216.565 284.380 372.895 1.00 36.64 ? 232 SER C N   1 
ATOM   5431 C CA  . SER C 3 232 ? 216.925 285.680 373.440 1.00 37.54 ? 232 SER C CA  1 
ATOM   5432 C C   . SER C 3 232 ? 218.095 285.502 374.393 1.00 38.11 ? 232 SER C C   1 
ATOM   5433 O O   . SER C 3 232 ? 218.296 284.417 374.943 1.00 40.28 ? 232 SER C O   1 
ATOM   5434 C CB  . SER C 3 232 ? 215.748 286.337 374.169 1.00 36.97 ? 232 SER C CB  1 
ATOM   5435 O OG  . SER C 3 232 ? 215.461 285.670 375.383 1.00 43.33 ? 232 SER C OG  1 
ATOM   5436 N N   . GLN C 3 233 ? 218.858 286.570 374.577 1.00 43.21 ? 233 GLN C N   1 
ATOM   5437 C CA  . GLN C 3 233 ? 220.030 286.567 375.433 1.00 43.53 ? 233 GLN C CA  1 
ATOM   5438 C C   . GLN C 3 233 ? 219.874 287.617 376.523 1.00 45.85 ? 233 GLN C C   1 
ATOM   5439 O O   . GLN C 3 233 ? 219.449 288.746 376.264 1.00 47.51 ? 233 GLN C O   1 
ATOM   5440 C CB  . GLN C 3 233 ? 221.291 286.835 374.613 1.00 43.46 ? 233 GLN C CB  1 
ATOM   5441 C CG  . GLN C 3 233 ? 222.577 286.696 375.386 1.00 43.50 ? 233 GLN C CG  1 
ATOM   5442 C CD  . GLN C 3 233 ? 223.786 286.682 374.483 1.00 44.91 ? 233 GLN C CD  1 
ATOM   5443 O OE1 . GLN C 3 233 ? 223.661 286.694 373.258 1.00 44.17 ? 233 GLN C OE1 1 
ATOM   5444 N NE2 . GLN C 3 233 ? 224.968 286.647 375.081 1.00 49.34 ? 233 GLN C NE2 1 
ATOM   5445 N N   . GLU C 3 234 ? 220.216 287.232 377.747 1.00 51.74 ? 234 GLU C N   1 
ATOM   5446 C CA  . GLU C 3 234 ? 220.092 288.121 378.896 1.00 52.08 ? 234 GLU C CA  1 
ATOM   5447 C C   . GLU C 3 234 ? 221.458 288.391 379.517 1.00 52.16 ? 234 GLU C C   1 
ATOM   5448 O O   . GLU C 3 234 ? 221.601 288.420 380.739 1.00 53.49 ? 234 GLU C O   1 
ATOM   5449 C CB  . GLU C 3 234 ? 219.148 287.519 379.938 1.00 52.07 ? 234 GLU C CB  1 
ATOM   5450 C CG  . GLU C 3 234 ? 217.762 287.176 379.402 1.00 52.53 ? 234 GLU C CG  1 
ATOM   5451 C CD  . GLU C 3 234 ? 216.973 288.403 378.984 1.00 55.59 ? 234 GLU C CD  1 
ATOM   5452 O OE1 . GLU C 3 234 ? 217.372 289.526 379.362 1.00 54.04 ? 234 GLU C OE1 1 
ATOM   5453 O OE2 . GLU C 3 234 ? 215.957 288.245 378.275 1.00 53.35 ? 234 GLU C OE2 1 
HETATM 5454 C C1  . SPH D 4 .   ? 233.512 275.707 365.341 1.00 23.49 ? 401 SPH A C1  1 
HETATM 5455 O O1  . SPH D 4 .   ? 232.689 274.557 365.367 1.00 22.59 ? 401 SPH A O1  1 
HETATM 5456 C C2  . SPH D 4 .   ? 233.491 276.408 363.980 1.00 20.59 ? 401 SPH A C2  1 
HETATM 5457 N N2  . SPH D 4 .   ? 232.164 276.303 363.398 1.00 22.78 ? 401 SPH A N2  1 
HETATM 5458 C C3  . SPH D 4 .   ? 233.864 277.889 364.071 1.00 26.32 ? 401 SPH A C3  1 
HETATM 5459 O O3  . SPH D 4 .   ? 234.362 278.230 365.344 1.00 32.75 ? 401 SPH A O3  1 
HETATM 5460 C C4  . SPH D 4 .   ? 234.874 278.268 363.022 1.00 20.95 ? 401 SPH A C4  1 
HETATM 5461 C C5  . SPH D 4 .   ? 235.916 279.262 363.328 1.00 18.57 ? 401 SPH A C5  1 
HETATM 5462 C C6  . SPH D 4 .   ? 236.800 279.795 362.224 1.00 24.14 ? 401 SPH A C6  1 
HETATM 5463 C C7  . SPH D 4 .   ? 238.275 279.692 362.599 1.00 22.62 ? 401 SPH A C7  1 
HETATM 5464 C C8  . SPH D 4 .   ? 238.678 280.792 363.576 1.00 21.73 ? 401 SPH A C8  1 
HETATM 5465 C C9  . SPH D 4 .   ? 240.116 281.254 363.360 1.00 21.99 ? 401 SPH A C9  1 
HETATM 5466 C C10 . SPH D 4 .   ? 240.212 282.193 362.161 1.00 23.21 ? 401 SPH A C10 1 
HETATM 5467 C C11 . SPH D 4 .   ? 241.495 283.017 362.155 1.00 19.82 ? 401 SPH A C11 1 
HETATM 5468 C C12 . SPH D 4 .   ? 241.422 284.182 363.131 1.00 20.89 ? 401 SPH A C12 1 
HETATM 5469 C C13 . SPH D 4 .   ? 241.290 285.524 362.424 1.00 24.22 ? 401 SPH A C13 1 
HETATM 5470 C C14 . SPH D 4 .   ? 242.585 285.996 361.778 1.00 17.78 ? 401 SPH A C14 1 
HETATM 5471 C C15 . SPH D 4 .   ? 242.510 287.492 361.497 1.00 20.01 ? 401 SPH A C15 1 
HETATM 5472 C C16 . SPH D 4 .   ? 243.031 288.357 362.638 1.00 18.24 ? 401 SPH A C16 1 
HETATM 5473 C C17 . SPH D 4 .   ? 243.801 289.572 362.139 1.00 17.68 ? 401 SPH A C17 1 
HETATM 5474 C C18 . SPH D 4 .   ? 245.146 289.185 361.549 1.00 19.78 ? 401 SPH A C18 1 
# 
