data_9H45
# 
_entry.id   9H45 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.401 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9H45         pdb_00009h45 10.2210/pdb9h45/pdb 
WWPDB D_1292142509 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-02-05 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9H45 
_pdbx_database_status.recvd_initial_deposition_date   2024-10-17 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              bfl20@cam.ac.uk 
_pdbx_contact_author.name_first         Ben 
_pdbx_contact_author.name_last          Luisi 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-1144-9877 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'McQuail, J.'         1  ? 
'Krepl, M.'           2  ? 
'Katsuya-Gaviria, K.' 3  ? 
'Tabib-Salazar, A.'   4  ? 
'Burchell, L.'        5  ? 
'Bischler, T.'        6  ? 
'Grafenhan, T.'       7  ? 
'Brear, P.'           8  ? 
'Sponer, J.'          9  ? 
'Luisi, B.'           10 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Nucleic Acids Res.' 
_citation.journal_id_ASTM           NARHAD 
_citation.journal_id_CSD            0389 
_citation.journal_id_ISSN           1362-4962 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            53 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
;Transcriptome-scale analysis uncovers conserved residues in the hydrophobic core of the bacterial RNA chaperone Hfq required for small regulatory RNA stability.
;
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1093/nar/gkaf019 
_citation.pdbx_database_id_PubMed   39868539 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'McQuail, J.'         1  ?                   
primary 'Krepl, M.'           2  0000-0002-9833-4281 
primary 'Katsuya-Gaviria, K.' 3  ?                   
primary 'Tabib-Salazar, A.'   4  ?                   
primary 'Burchell, L.'        5  ?                   
primary 'Bischler, T.'        6  ?                   
primary 'Grafenhan, T.'       7  ?                   
primary 'Brear, P.'           8  ?                   
primary 'Sponer, J.'          9  ?                   
primary 'Luisi, B.F.'         10 0000-0003-1144-9877 
primary 'Wigneshweraraj, S.'  11 0000-0002-1418-4029 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man 'RNA-binding protein Hfq'                                               11151.301 6   ? ? ? ? 
2 polymer syn 
;RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3')
;
5880.748  1   ? ? ? ? 
3 water   nat water                                                                   18.015    282 ? ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'HF-1,Host factor-I protein,HF-I' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)'   no no 
;MAKGQSLQDPFLNALRRERVPASIYLVNGIKLQGQIESFDQFVILLKNTVSQMVYKHAISTVVPSRPVSHHSNNAGGGTS
SNYHHGSSAQNTSAQQDSEETE
;
;MAKGQSLQDPFLNALRRERVPASIYLVNGIKLQGQIESFDQFVILLKNTVSQMVYKHAISTVVPSRPVSHHSNNAGGGTS
SNYHHGSSAQNTSAQQDSEETE
;
A,B,C,D,E,F ? 
2 polyribonucleotide no no AAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAA Q           ? 
# 
_pdbx_entity_nonpoly.entity_id   3 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ALA n 
1 3   LYS n 
1 4   GLY n 
1 5   GLN n 
1 6   SER n 
1 7   LEU n 
1 8   GLN n 
1 9   ASP n 
1 10  PRO n 
1 11  PHE n 
1 12  LEU n 
1 13  ASN n 
1 14  ALA n 
1 15  LEU n 
1 16  ARG n 
1 17  ARG n 
1 18  GLU n 
1 19  ARG n 
1 20  VAL n 
1 21  PRO n 
1 22  ALA n 
1 23  SER n 
1 24  ILE n 
1 25  TYR n 
1 26  LEU n 
1 27  VAL n 
1 28  ASN n 
1 29  GLY n 
1 30  ILE n 
1 31  LYS n 
1 32  LEU n 
1 33  GLN n 
1 34  GLY n 
1 35  GLN n 
1 36  ILE n 
1 37  GLU n 
1 38  SER n 
1 39  PHE n 
1 40  ASP n 
1 41  GLN n 
1 42  PHE n 
1 43  VAL n 
1 44  ILE n 
1 45  LEU n 
1 46  LEU n 
1 47  LYS n 
1 48  ASN n 
1 49  THR n 
1 50  VAL n 
1 51  SER n 
1 52  GLN n 
1 53  MET n 
1 54  VAL n 
1 55  TYR n 
1 56  LYS n 
1 57  HIS n 
1 58  ALA n 
1 59  ILE n 
1 60  SER n 
1 61  THR n 
1 62  VAL n 
1 63  VAL n 
1 64  PRO n 
1 65  SER n 
1 66  ARG n 
1 67  PRO n 
1 68  VAL n 
1 69  SER n 
1 70  HIS n 
1 71  HIS n 
1 72  SER n 
1 73  ASN n 
1 74  ASN n 
1 75  ALA n 
1 76  GLY n 
1 77  GLY n 
1 78  GLY n 
1 79  THR n 
1 80  SER n 
1 81  SER n 
1 82  ASN n 
1 83  TYR n 
1 84  HIS n 
1 85  HIS n 
1 86  GLY n 
1 87  SER n 
1 88  SER n 
1 89  ALA n 
1 90  GLN n 
1 91  ASN n 
1 92  THR n 
1 93  SER n 
1 94  ALA n 
1 95  GLN n 
1 96  GLN n 
1 97  ASP n 
1 98  SER n 
1 99  GLU n 
1 100 GLU n 
1 101 THR n 
1 102 GLU n 
2 1   A   n 
2 2   A   n 
2 3   A   n 
2 4   A   n 
2 5   A   n 
2 6   A   n 
2 7   A   n 
2 8   A   n 
2 9   A   n 
2 10  A   n 
2 11  A   n 
2 12  A   n 
2 13  A   n 
2 14  A   n 
2 15  A   n 
2 16  A   n 
2 17  A   n 
2 18  A   n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   102 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'hfq, b4172, JW4130' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    K12 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Escherichia coli (strain K12)' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     83333 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
_pdbx_entity_src_syn.entity_id              2 
_pdbx_entity_src_syn.pdbx_src_id            1 
_pdbx_entity_src_syn.pdbx_alt_source_flag   sample 
_pdbx_entity_src_syn.pdbx_beg_seq_num       1 
_pdbx_entity_src_syn.pdbx_end_seq_num       18 
_pdbx_entity_src_syn.organism_scientific    'Homo sapiens' 
_pdbx_entity_src_syn.organism_common_name   human 
_pdbx_entity_src_syn.ncbi_taxonomy_id       9606 
_pdbx_entity_src_syn.details                ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A   'RNA linking'       y "ADENOSINE-5'-MONOPHOSPHATE" ? 'C10 H14 N5 O7 P' 347.221 
ALA 'L-peptide linking' y ALANINE                      ? 'C3 H7 N O2'      89.093  
ARG 'L-peptide linking' y ARGININE                     ? 'C6 H15 N4 O2 1'  175.209 
ASN 'L-peptide linking' y ASPARAGINE                   ? 'C4 H8 N2 O3'     132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'              ? 'C4 H7 N O4'      133.103 
GLN 'L-peptide linking' y GLUTAMINE                    ? 'C5 H10 N2 O3'    146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'              ? 'C5 H9 N O4'      147.129 
GLY 'peptide linking'   y GLYCINE                      ? 'C2 H5 N O2'      75.067  
HIS 'L-peptide linking' y HISTIDINE                    ? 'C6 H10 N3 O2 1'  156.162 
HOH non-polymer         . WATER                        ? 'H2 O'            18.015  
ILE 'L-peptide linking' y ISOLEUCINE                   ? 'C6 H13 N O2'     131.173 
LEU 'L-peptide linking' y LEUCINE                      ? 'C6 H13 N O2'     131.173 
LYS 'L-peptide linking' y LYSINE                       ? 'C6 H15 N2 O2 1'  147.195 
MET 'L-peptide linking' y METHIONINE                   ? 'C5 H11 N O2 S'   149.211 
PHE 'L-peptide linking' y PHENYLALANINE                ? 'C9 H11 N O2'     165.189 
PRO 'L-peptide linking' y PROLINE                      ? 'C5 H9 N O2'      115.130 
SER 'L-peptide linking' y SERINE                       ? 'C3 H7 N O3'      105.093 
THR 'L-peptide linking' y THREONINE                    ? 'C4 H9 N O3'      119.119 
TYR 'L-peptide linking' y TYROSINE                     ? 'C9 H11 N O3'     181.189 
VAL 'L-peptide linking' y VALINE                       ? 'C5 H11 N O2'     117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?  ?   ?   A . n 
A 1 2   ALA 2   2   ?  ?   ?   A . n 
A 1 3   LYS 3   3   ?  ?   ?   A . n 
A 1 4   GLY 4   4   ?  ?   ?   A . n 
A 1 5   GLN 5   5   5  GLN GLN A . n 
A 1 6   SER 6   6   6  SER SER A . n 
A 1 7   LEU 7   7   7  LEU LEU A . n 
A 1 8   GLN 8   8   8  GLN GLN A . n 
A 1 9   ASP 9   9   9  ASP ASP A . n 
A 1 10  PRO 10  10  10 PRO PRO A . n 
A 1 11  PHE 11  11  11 PHE PHE A . n 
A 1 12  LEU 12  12  12 LEU LEU A . n 
A 1 13  ASN 13  13  13 ASN ASN A . n 
A 1 14  ALA 14  14  14 ALA ALA A . n 
A 1 15  LEU 15  15  15 LEU LEU A . n 
A 1 16  ARG 16  16  16 ARG ARG A . n 
A 1 17  ARG 17  17  17 ARG ARG A . n 
A 1 18  GLU 18  18  18 GLU GLU A . n 
A 1 19  ARG 19  19  19 ARG ARG A . n 
A 1 20  VAL 20  20  20 VAL VAL A . n 
A 1 21  PRO 21  21  21 PRO PRO A . n 
A 1 22  ALA 22  22  22 ALA ALA A . n 
A 1 23  SER 23  23  23 SER SER A . n 
A 1 24  ILE 24  24  24 ILE ILE A . n 
A 1 25  TYR 25  25  25 TYR TYR A . n 
A 1 26  LEU 26  26  26 LEU LEU A . n 
A 1 27  VAL 27  27  27 VAL VAL A . n 
A 1 28  ASN 28  28  28 ASN ASN A . n 
A 1 29  GLY 29  29  29 GLY GLY A . n 
A 1 30  ILE 30  30  30 ILE ILE A . n 
A 1 31  LYS 31  31  31 LYS LYS A . n 
A 1 32  LEU 32  32  32 LEU LEU A . n 
A 1 33  GLN 33  33  33 GLN GLN A . n 
A 1 34  GLY 34  34  34 GLY GLY A . n 
A 1 35  GLN 35  35  35 GLN GLN A . n 
A 1 36  ILE 36  36  36 ILE ILE A . n 
A 1 37  GLU 37  37  37 GLU GLU A . n 
A 1 38  SER 38  38  38 SER SER A . n 
A 1 39  PHE 39  39  39 PHE PHE A . n 
A 1 40  ASP 40  40  40 ASP ASP A . n 
A 1 41  GLN 41  41  41 GLN GLN A . n 
A 1 42  PHE 42  42  42 PHE PHE A . n 
A 1 43  VAL 43  43  43 VAL VAL A . n 
A 1 44  ILE 44  44  44 ILE ILE A . n 
A 1 45  LEU 45  45  45 LEU LEU A . n 
A 1 46  LEU 46  46  46 LEU LEU A . n 
A 1 47  LYS 47  47  47 LYS LYS A . n 
A 1 48  ASN 48  48  48 ASN ASN A . n 
A 1 49  THR 49  49  49 THR THR A . n 
A 1 50  VAL 50  50  50 VAL VAL A . n 
A 1 51  SER 51  51  51 SER SER A . n 
A 1 52  GLN 52  52  52 GLN GLN A . n 
A 1 53  MET 53  53  53 MET MET A . n 
A 1 54  VAL 54  54  54 VAL VAL A . n 
A 1 55  TYR 55  55  55 TYR TYR A . n 
A 1 56  LYS 56  56  56 LYS LYS A . n 
A 1 57  HIS 57  57  57 HIS HIS A . n 
A 1 58  ALA 58  58  58 ALA ALA A . n 
A 1 59  ILE 59  59  59 ILE ILE A . n 
A 1 60  SER 60  60  60 SER SER A . n 
A 1 61  THR 61  61  61 THR THR A . n 
A 1 62  VAL 62  62  62 VAL VAL A . n 
A 1 63  VAL 63  63  63 VAL VAL A . n 
A 1 64  PRO 64  64  64 PRO PRO A . n 
A 1 65  SER 65  65  65 SER SER A . n 
A 1 66  ARG 66  66  66 ARG ARG A . n 
A 1 67  PRO 67  67  67 PRO PRO A . n 
A 1 68  VAL 68  68  68 VAL VAL A . n 
A 1 69  SER 69  69  69 SER SER A . n 
A 1 70  HIS 70  70  ?  ?   ?   A . n 
A 1 71  HIS 71  71  ?  ?   ?   A . n 
A 1 72  SER 72  72  ?  ?   ?   A . n 
A 1 73  ASN 73  73  ?  ?   ?   A . n 
A 1 74  ASN 74  74  ?  ?   ?   A . n 
A 1 75  ALA 75  75  ?  ?   ?   A . n 
A 1 76  GLY 76  76  ?  ?   ?   A . n 
A 1 77  GLY 77  77  ?  ?   ?   A . n 
A 1 78  GLY 78  78  ?  ?   ?   A . n 
A 1 79  THR 79  79  ?  ?   ?   A . n 
A 1 80  SER 80  80  ?  ?   ?   A . n 
A 1 81  SER 81  81  ?  ?   ?   A . n 
A 1 82  ASN 82  82  ?  ?   ?   A . n 
A 1 83  TYR 83  83  ?  ?   ?   A . n 
A 1 84  HIS 84  84  ?  ?   ?   A . n 
A 1 85  HIS 85  85  ?  ?   ?   A . n 
A 1 86  GLY 86  86  ?  ?   ?   A . n 
A 1 87  SER 87  87  ?  ?   ?   A . n 
A 1 88  SER 88  88  ?  ?   ?   A . n 
A 1 89  ALA 89  89  ?  ?   ?   A . n 
A 1 90  GLN 90  90  ?  ?   ?   A . n 
A 1 91  ASN 91  91  ?  ?   ?   A . n 
A 1 92  THR 92  92  ?  ?   ?   A . n 
A 1 93  SER 93  93  ?  ?   ?   A . n 
A 1 94  ALA 94  94  ?  ?   ?   A . n 
A 1 95  GLN 95  95  ?  ?   ?   A . n 
A 1 96  GLN 96  96  ?  ?   ?   A . n 
A 1 97  ASP 97  97  ?  ?   ?   A . n 
A 1 98  SER 98  98  ?  ?   ?   A . n 
A 1 99  GLU 99  99  ?  ?   ?   A . n 
A 1 100 GLU 100 100 ?  ?   ?   A . n 
A 1 101 THR 101 101 ?  ?   ?   A . n 
A 1 102 GLU 102 102 ?  ?   ?   A . n 
B 1 1   MET 1   1   ?  ?   ?   B . n 
B 1 2   ALA 2   2   ?  ?   ?   B . n 
B 1 3   LYS 3   3   ?  ?   ?   B . n 
B 1 4   GLY 4   4   ?  ?   ?   B . n 
B 1 5   GLN 5   5   ?  ?   ?   B . n 
B 1 6   SER 6   6   6  SER SER B . n 
B 1 7   LEU 7   7   7  LEU LEU B . n 
B 1 8   GLN 8   8   8  GLN GLN B . n 
B 1 9   ASP 9   9   9  ASP ASP B . n 
B 1 10  PRO 10  10  10 PRO PRO B . n 
B 1 11  PHE 11  11  11 PHE PHE B . n 
B 1 12  LEU 12  12  12 LEU LEU B . n 
B 1 13  ASN 13  13  13 ASN ASN B . n 
B 1 14  ALA 14  14  14 ALA ALA B . n 
B 1 15  LEU 15  15  15 LEU LEU B . n 
B 1 16  ARG 16  16  16 ARG ARG B . n 
B 1 17  ARG 17  17  17 ARG ARG B . n 
B 1 18  GLU 18  18  18 GLU GLU B . n 
B 1 19  ARG 19  19  19 ARG ARG B . n 
B 1 20  VAL 20  20  20 VAL VAL B . n 
B 1 21  PRO 21  21  21 PRO PRO B . n 
B 1 22  ALA 22  22  22 ALA ALA B . n 
B 1 23  SER 23  23  23 SER SER B . n 
B 1 24  ILE 24  24  24 ILE ILE B . n 
B 1 25  TYR 25  25  25 TYR TYR B . n 
B 1 26  LEU 26  26  26 LEU LEU B . n 
B 1 27  VAL 27  27  27 VAL VAL B . n 
B 1 28  ASN 28  28  28 ASN ASN B . n 
B 1 29  GLY 29  29  29 GLY GLY B . n 
B 1 30  ILE 30  30  30 ILE ILE B . n 
B 1 31  LYS 31  31  31 LYS LYS B . n 
B 1 32  LEU 32  32  32 LEU LEU B . n 
B 1 33  GLN 33  33  33 GLN GLN B . n 
B 1 34  GLY 34  34  34 GLY GLY B . n 
B 1 35  GLN 35  35  35 GLN GLN B . n 
B 1 36  ILE 36  36  36 ILE ILE B . n 
B 1 37  GLU 37  37  37 GLU GLU B . n 
B 1 38  SER 38  38  38 SER SER B . n 
B 1 39  PHE 39  39  39 PHE PHE B . n 
B 1 40  ASP 40  40  40 ASP ASP B . n 
B 1 41  GLN 41  41  41 GLN GLN B . n 
B 1 42  PHE 42  42  42 PHE PHE B . n 
B 1 43  VAL 43  43  43 VAL VAL B . n 
B 1 44  ILE 44  44  44 ILE ILE B . n 
B 1 45  LEU 45  45  45 LEU LEU B . n 
B 1 46  LEU 46  46  46 LEU LEU B . n 
B 1 47  LYS 47  47  47 LYS LYS B . n 
B 1 48  ASN 48  48  48 ASN ASN B . n 
B 1 49  THR 49  49  49 THR THR B . n 
B 1 50  VAL 50  50  50 VAL VAL B . n 
B 1 51  SER 51  51  51 SER SER B . n 
B 1 52  GLN 52  52  52 GLN GLN B . n 
B 1 53  MET 53  53  53 MET MET B . n 
B 1 54  VAL 54  54  54 VAL VAL B . n 
B 1 55  TYR 55  55  55 TYR TYR B . n 
B 1 56  LYS 56  56  56 LYS LYS B . n 
B 1 57  HIS 57  57  57 HIS HIS B . n 
B 1 58  ALA 58  58  58 ALA ALA B . n 
B 1 59  ILE 59  59  59 ILE ILE B . n 
B 1 60  SER 60  60  60 SER SER B . n 
B 1 61  THR 61  61  61 THR THR B . n 
B 1 62  VAL 62  62  62 VAL VAL B . n 
B 1 63  VAL 63  63  63 VAL VAL B . n 
B 1 64  PRO 64  64  64 PRO PRO B . n 
B 1 65  SER 65  65  65 SER SER B . n 
B 1 66  ARG 66  66  66 ARG ARG B . n 
B 1 67  PRO 67  67  67 PRO PRO B . n 
B 1 68  VAL 68  68  68 VAL VAL B . n 
B 1 69  SER 69  69  ?  ?   ?   B . n 
B 1 70  HIS 70  70  ?  ?   ?   B . n 
B 1 71  HIS 71  71  ?  ?   ?   B . n 
B 1 72  SER 72  72  ?  ?   ?   B . n 
B 1 73  ASN 73  73  ?  ?   ?   B . n 
B 1 74  ASN 74  74  ?  ?   ?   B . n 
B 1 75  ALA 75  75  ?  ?   ?   B . n 
B 1 76  GLY 76  76  ?  ?   ?   B . n 
B 1 77  GLY 77  77  ?  ?   ?   B . n 
B 1 78  GLY 78  78  ?  ?   ?   B . n 
B 1 79  THR 79  79  ?  ?   ?   B . n 
B 1 80  SER 80  80  ?  ?   ?   B . n 
B 1 81  SER 81  81  ?  ?   ?   B . n 
B 1 82  ASN 82  82  ?  ?   ?   B . n 
B 1 83  TYR 83  83  ?  ?   ?   B . n 
B 1 84  HIS 84  84  ?  ?   ?   B . n 
B 1 85  HIS 85  85  ?  ?   ?   B . n 
B 1 86  GLY 86  86  ?  ?   ?   B . n 
B 1 87  SER 87  87  ?  ?   ?   B . n 
B 1 88  SER 88  88  ?  ?   ?   B . n 
B 1 89  ALA 89  89  ?  ?   ?   B . n 
B 1 90  GLN 90  90  ?  ?   ?   B . n 
B 1 91  ASN 91  91  ?  ?   ?   B . n 
B 1 92  THR 92  92  ?  ?   ?   B . n 
B 1 93  SER 93  93  ?  ?   ?   B . n 
B 1 94  ALA 94  94  ?  ?   ?   B . n 
B 1 95  GLN 95  95  ?  ?   ?   B . n 
B 1 96  GLN 96  96  ?  ?   ?   B . n 
B 1 97  ASP 97  97  ?  ?   ?   B . n 
B 1 98  SER 98  98  ?  ?   ?   B . n 
B 1 99  GLU 99  99  ?  ?   ?   B . n 
B 1 100 GLU 100 100 ?  ?   ?   B . n 
B 1 101 THR 101 101 ?  ?   ?   B . n 
B 1 102 GLU 102 102 ?  ?   ?   B . n 
C 1 1   MET 1   1   ?  ?   ?   C . n 
C 1 2   ALA 2   2   ?  ?   ?   C . n 
C 1 3   LYS 3   3   ?  ?   ?   C . n 
C 1 4   GLY 4   4   ?  ?   ?   C . n 
C 1 5   GLN 5   5   ?  ?   ?   C . n 
C 1 6   SER 6   6   6  SER SER C . n 
C 1 7   LEU 7   7   7  LEU LEU C . n 
C 1 8   GLN 8   8   8  GLN GLN C . n 
C 1 9   ASP 9   9   9  ASP ASP C . n 
C 1 10  PRO 10  10  10 PRO PRO C . n 
C 1 11  PHE 11  11  11 PHE PHE C . n 
C 1 12  LEU 12  12  12 LEU LEU C . n 
C 1 13  ASN 13  13  13 ASN ASN C . n 
C 1 14  ALA 14  14  14 ALA ALA C . n 
C 1 15  LEU 15  15  15 LEU LEU C . n 
C 1 16  ARG 16  16  16 ARG ARG C . n 
C 1 17  ARG 17  17  17 ARG ARG C . n 
C 1 18  GLU 18  18  18 GLU GLU C . n 
C 1 19  ARG 19  19  19 ARG ARG C . n 
C 1 20  VAL 20  20  20 VAL VAL C . n 
C 1 21  PRO 21  21  21 PRO PRO C . n 
C 1 22  ALA 22  22  22 ALA ALA C . n 
C 1 23  SER 23  23  23 SER SER C . n 
C 1 24  ILE 24  24  24 ILE ILE C . n 
C 1 25  TYR 25  25  25 TYR TYR C . n 
C 1 26  LEU 26  26  26 LEU LEU C . n 
C 1 27  VAL 27  27  27 VAL VAL C . n 
C 1 28  ASN 28  28  28 ASN ASN C . n 
C 1 29  GLY 29  29  29 GLY GLY C . n 
C 1 30  ILE 30  30  30 ILE ILE C . n 
C 1 31  LYS 31  31  31 LYS LYS C . n 
C 1 32  LEU 32  32  32 LEU LEU C . n 
C 1 33  GLN 33  33  33 GLN GLN C . n 
C 1 34  GLY 34  34  34 GLY GLY C . n 
C 1 35  GLN 35  35  35 GLN GLN C . n 
C 1 36  ILE 36  36  36 ILE ILE C . n 
C 1 37  GLU 37  37  37 GLU GLU C . n 
C 1 38  SER 38  38  38 SER SER C . n 
C 1 39  PHE 39  39  39 PHE PHE C . n 
C 1 40  ASP 40  40  40 ASP ASP C . n 
C 1 41  GLN 41  41  41 GLN GLN C . n 
C 1 42  PHE 42  42  42 PHE PHE C . n 
C 1 43  VAL 43  43  43 VAL VAL C . n 
C 1 44  ILE 44  44  44 ILE ILE C . n 
C 1 45  LEU 45  45  45 LEU LEU C . n 
C 1 46  LEU 46  46  46 LEU LEU C . n 
C 1 47  LYS 47  47  47 LYS LYS C . n 
C 1 48  ASN 48  48  48 ASN ASN C . n 
C 1 49  THR 49  49  49 THR THR C . n 
C 1 50  VAL 50  50  50 VAL VAL C . n 
C 1 51  SER 51  51  51 SER SER C . n 
C 1 52  GLN 52  52  52 GLN GLN C . n 
C 1 53  MET 53  53  53 MET MET C . n 
C 1 54  VAL 54  54  54 VAL VAL C . n 
C 1 55  TYR 55  55  55 TYR TYR C . n 
C 1 56  LYS 56  56  56 LYS LYS C . n 
C 1 57  HIS 57  57  57 HIS HIS C . n 
C 1 58  ALA 58  58  58 ALA ALA C . n 
C 1 59  ILE 59  59  59 ILE ILE C . n 
C 1 60  SER 60  60  60 SER SER C . n 
C 1 61  THR 61  61  61 THR THR C . n 
C 1 62  VAL 62  62  62 VAL VAL C . n 
C 1 63  VAL 63  63  63 VAL VAL C . n 
C 1 64  PRO 64  64  64 PRO PRO C . n 
C 1 65  SER 65  65  65 SER SER C . n 
C 1 66  ARG 66  66  66 ARG ARG C . n 
C 1 67  PRO 67  67  67 PRO PRO C . n 
C 1 68  VAL 68  68  68 VAL VAL C . n 
C 1 69  SER 69  69  ?  ?   ?   C . n 
C 1 70  HIS 70  70  ?  ?   ?   C . n 
C 1 71  HIS 71  71  ?  ?   ?   C . n 
C 1 72  SER 72  72  ?  ?   ?   C . n 
C 1 73  ASN 73  73  ?  ?   ?   C . n 
C 1 74  ASN 74  74  ?  ?   ?   C . n 
C 1 75  ALA 75  75  ?  ?   ?   C . n 
C 1 76  GLY 76  76  ?  ?   ?   C . n 
C 1 77  GLY 77  77  ?  ?   ?   C . n 
C 1 78  GLY 78  78  ?  ?   ?   C . n 
C 1 79  THR 79  79  ?  ?   ?   C . n 
C 1 80  SER 80  80  ?  ?   ?   C . n 
C 1 81  SER 81  81  ?  ?   ?   C . n 
C 1 82  ASN 82  82  ?  ?   ?   C . n 
C 1 83  TYR 83  83  ?  ?   ?   C . n 
C 1 84  HIS 84  84  ?  ?   ?   C . n 
C 1 85  HIS 85  85  ?  ?   ?   C . n 
C 1 86  GLY 86  86  ?  ?   ?   C . n 
C 1 87  SER 87  87  ?  ?   ?   C . n 
C 1 88  SER 88  88  ?  ?   ?   C . n 
C 1 89  ALA 89  89  ?  ?   ?   C . n 
C 1 90  GLN 90  90  ?  ?   ?   C . n 
C 1 91  ASN 91  91  ?  ?   ?   C . n 
C 1 92  THR 92  92  ?  ?   ?   C . n 
C 1 93  SER 93  93  ?  ?   ?   C . n 
C 1 94  ALA 94  94  ?  ?   ?   C . n 
C 1 95  GLN 95  95  ?  ?   ?   C . n 
C 1 96  GLN 96  96  ?  ?   ?   C . n 
C 1 97  ASP 97  97  ?  ?   ?   C . n 
C 1 98  SER 98  98  ?  ?   ?   C . n 
C 1 99  GLU 99  99  ?  ?   ?   C . n 
C 1 100 GLU 100 100 ?  ?   ?   C . n 
C 1 101 THR 101 101 ?  ?   ?   C . n 
C 1 102 GLU 102 102 ?  ?   ?   C . n 
D 1 1   MET 1   1   ?  ?   ?   D . n 
D 1 2   ALA 2   2   ?  ?   ?   D . n 
D 1 3   LYS 3   3   ?  ?   ?   D . n 
D 1 4   GLY 4   4   ?  ?   ?   D . n 
D 1 5   GLN 5   5   ?  ?   ?   D . n 
D 1 6   SER 6   6   ?  ?   ?   D . n 
D 1 7   LEU 7   7   7  LEU LEU D . n 
D 1 8   GLN 8   8   8  GLN GLN D . n 
D 1 9   ASP 9   9   9  ASP ASP D . n 
D 1 10  PRO 10  10  10 PRO PRO D . n 
D 1 11  PHE 11  11  11 PHE PHE D . n 
D 1 12  LEU 12  12  12 LEU LEU D . n 
D 1 13  ASN 13  13  13 ASN ASN D . n 
D 1 14  ALA 14  14  ?  ?   ?   D . n 
D 1 15  LEU 15  15  15 LEU LEU D . n 
D 1 16  ARG 16  16  16 ARG ARG D . n 
D 1 17  ARG 17  17  17 ARG ARG D . n 
D 1 18  GLU 18  18  18 GLU GLU D . n 
D 1 19  ARG 19  19  19 ARG ARG D . n 
D 1 20  VAL 20  20  20 VAL VAL D . n 
D 1 21  PRO 21  21  21 PRO PRO D . n 
D 1 22  ALA 22  22  22 ALA ALA D . n 
D 1 23  SER 23  23  23 SER SER D . n 
D 1 24  ILE 24  24  24 ILE ILE D . n 
D 1 25  TYR 25  25  25 TYR TYR D . n 
D 1 26  LEU 26  26  26 LEU LEU D . n 
D 1 27  VAL 27  27  27 VAL VAL D . n 
D 1 28  ASN 28  28  28 ASN ASN D . n 
D 1 29  GLY 29  29  29 GLY GLY D . n 
D 1 30  ILE 30  30  30 ILE ILE D . n 
D 1 31  LYS 31  31  31 LYS LYS D . n 
D 1 32  LEU 32  32  32 LEU LEU D . n 
D 1 33  GLN 33  33  33 GLN GLN D . n 
D 1 34  GLY 34  34  34 GLY GLY D . n 
D 1 35  GLN 35  35  35 GLN GLN D . n 
D 1 36  ILE 36  36  36 ILE ILE D . n 
D 1 37  GLU 37  37  37 GLU GLU D . n 
D 1 38  SER 38  38  38 SER SER D . n 
D 1 39  PHE 39  39  39 PHE PHE D . n 
D 1 40  ASP 40  40  40 ASP ASP D . n 
D 1 41  GLN 41  41  41 GLN GLN D . n 
D 1 42  PHE 42  42  42 PHE PHE D . n 
D 1 43  VAL 43  43  43 VAL VAL D . n 
D 1 44  ILE 44  44  44 ILE ILE D . n 
D 1 45  LEU 45  45  45 LEU LEU D . n 
D 1 46  LEU 46  46  46 LEU LEU D . n 
D 1 47  LYS 47  47  47 LYS LYS D . n 
D 1 48  ASN 48  48  48 ASN ASN D . n 
D 1 49  THR 49  49  49 THR THR D . n 
D 1 50  VAL 50  50  50 VAL VAL D . n 
D 1 51  SER 51  51  51 SER SER D . n 
D 1 52  GLN 52  52  52 GLN GLN D . n 
D 1 53  MET 53  53  53 MET MET D . n 
D 1 54  VAL 54  54  54 VAL VAL D . n 
D 1 55  TYR 55  55  55 TYR TYR D . n 
D 1 56  LYS 56  56  56 LYS LYS D . n 
D 1 57  HIS 57  57  57 HIS HIS D . n 
D 1 58  ALA 58  58  58 ALA ALA D . n 
D 1 59  ILE 59  59  59 ILE ILE D . n 
D 1 60  SER 60  60  60 SER SER D . n 
D 1 61  THR 61  61  61 THR THR D . n 
D 1 62  VAL 62  62  62 VAL VAL D . n 
D 1 63  VAL 63  63  63 VAL VAL D . n 
D 1 64  PRO 64  64  64 PRO PRO D . n 
D 1 65  SER 65  65  65 SER SER D . n 
D 1 66  ARG 66  66  66 ARG ARG D . n 
D 1 67  PRO 67  67  67 PRO PRO D . n 
D 1 68  VAL 68  68  68 VAL VAL D . n 
D 1 69  SER 69  69  ?  ?   ?   D . n 
D 1 70  HIS 70  70  ?  ?   ?   D . n 
D 1 71  HIS 71  71  ?  ?   ?   D . n 
D 1 72  SER 72  72  ?  ?   ?   D . n 
D 1 73  ASN 73  73  ?  ?   ?   D . n 
D 1 74  ASN 74  74  ?  ?   ?   D . n 
D 1 75  ALA 75  75  ?  ?   ?   D . n 
D 1 76  GLY 76  76  ?  ?   ?   D . n 
D 1 77  GLY 77  77  ?  ?   ?   D . n 
D 1 78  GLY 78  78  ?  ?   ?   D . n 
D 1 79  THR 79  79  ?  ?   ?   D . n 
D 1 80  SER 80  80  ?  ?   ?   D . n 
D 1 81  SER 81  81  ?  ?   ?   D . n 
D 1 82  ASN 82  82  ?  ?   ?   D . n 
D 1 83  TYR 83  83  ?  ?   ?   D . n 
D 1 84  HIS 84  84  ?  ?   ?   D . n 
D 1 85  HIS 85  85  ?  ?   ?   D . n 
D 1 86  GLY 86  86  ?  ?   ?   D . n 
D 1 87  SER 87  87  ?  ?   ?   D . n 
D 1 88  SER 88  88  ?  ?   ?   D . n 
D 1 89  ALA 89  89  ?  ?   ?   D . n 
D 1 90  GLN 90  90  ?  ?   ?   D . n 
D 1 91  ASN 91  91  ?  ?   ?   D . n 
D 1 92  THR 92  92  ?  ?   ?   D . n 
D 1 93  SER 93  93  ?  ?   ?   D . n 
D 1 94  ALA 94  94  ?  ?   ?   D . n 
D 1 95  GLN 95  95  ?  ?   ?   D . n 
D 1 96  GLN 96  96  ?  ?   ?   D . n 
D 1 97  ASP 97  97  ?  ?   ?   D . n 
D 1 98  SER 98  98  ?  ?   ?   D . n 
D 1 99  GLU 99  99  ?  ?   ?   D . n 
D 1 100 GLU 100 100 ?  ?   ?   D . n 
D 1 101 THR 101 101 ?  ?   ?   D . n 
D 1 102 GLU 102 102 ?  ?   ?   D . n 
E 1 1   MET 1   1   ?  ?   ?   E . n 
E 1 2   ALA 2   2   ?  ?   ?   E . n 
E 1 3   LYS 3   3   ?  ?   ?   E . n 
E 1 4   GLY 4   4   ?  ?   ?   E . n 
E 1 5   GLN 5   5   ?  ?   ?   E . n 
E 1 6   SER 6   6   6  SER SER E . n 
E 1 7   LEU 7   7   7  LEU LEU E . n 
E 1 8   GLN 8   8   8  GLN GLN E . n 
E 1 9   ASP 9   9   9  ASP ASP E . n 
E 1 10  PRO 10  10  10 PRO PRO E . n 
E 1 11  PHE 11  11  11 PHE PHE E . n 
E 1 12  LEU 12  12  12 LEU LEU E . n 
E 1 13  ASN 13  13  13 ASN ASN E . n 
E 1 14  ALA 14  14  14 ALA ALA E . n 
E 1 15  LEU 15  15  15 LEU LEU E . n 
E 1 16  ARG 16  16  16 ARG ARG E . n 
E 1 17  ARG 17  17  17 ARG ARG E . n 
E 1 18  GLU 18  18  18 GLU GLU E . n 
E 1 19  ARG 19  19  19 ARG ARG E . n 
E 1 20  VAL 20  20  20 VAL VAL E . n 
E 1 21  PRO 21  21  21 PRO PRO E . n 
E 1 22  ALA 22  22  22 ALA ALA E . n 
E 1 23  SER 23  23  23 SER SER E . n 
E 1 24  ILE 24  24  24 ILE ILE E . n 
E 1 25  TYR 25  25  25 TYR TYR E . n 
E 1 26  LEU 26  26  26 LEU LEU E . n 
E 1 27  VAL 27  27  27 VAL VAL E . n 
E 1 28  ASN 28  28  28 ASN ASN E . n 
E 1 29  GLY 29  29  29 GLY GLY E . n 
E 1 30  ILE 30  30  30 ILE ILE E . n 
E 1 31  LYS 31  31  31 LYS LYS E . n 
E 1 32  LEU 32  32  32 LEU LEU E . n 
E 1 33  GLN 33  33  33 GLN GLN E . n 
E 1 34  GLY 34  34  34 GLY GLY E . n 
E 1 35  GLN 35  35  35 GLN GLN E . n 
E 1 36  ILE 36  36  36 ILE ILE E . n 
E 1 37  GLU 37  37  37 GLU GLU E . n 
E 1 38  SER 38  38  38 SER SER E . n 
E 1 39  PHE 39  39  39 PHE PHE E . n 
E 1 40  ASP 40  40  40 ASP ASP E . n 
E 1 41  GLN 41  41  41 GLN GLN E . n 
E 1 42  PHE 42  42  42 PHE PHE E . n 
E 1 43  VAL 43  43  43 VAL VAL E . n 
E 1 44  ILE 44  44  44 ILE ILE E . n 
E 1 45  LEU 45  45  45 LEU LEU E . n 
E 1 46  LEU 46  46  46 LEU LEU E . n 
E 1 47  LYS 47  47  47 LYS LYS E . n 
E 1 48  ASN 48  48  48 ASN ASN E . n 
E 1 49  THR 49  49  49 THR THR E . n 
E 1 50  VAL 50  50  50 VAL VAL E . n 
E 1 51  SER 51  51  51 SER SER E . n 
E 1 52  GLN 52  52  52 GLN GLN E . n 
E 1 53  MET 53  53  53 MET MET E . n 
E 1 54  VAL 54  54  54 VAL VAL E . n 
E 1 55  TYR 55  55  55 TYR TYR E . n 
E 1 56  LYS 56  56  56 LYS LYS E . n 
E 1 57  HIS 57  57  57 HIS HIS E . n 
E 1 58  ALA 58  58  58 ALA ALA E . n 
E 1 59  ILE 59  59  59 ILE ILE E . n 
E 1 60  SER 60  60  60 SER SER E . n 
E 1 61  THR 61  61  61 THR THR E . n 
E 1 62  VAL 62  62  62 VAL VAL E . n 
E 1 63  VAL 63  63  63 VAL VAL E . n 
E 1 64  PRO 64  64  64 PRO PRO E . n 
E 1 65  SER 65  65  65 SER SER E . n 
E 1 66  ARG 66  66  66 ARG ARG E . n 
E 1 67  PRO 67  67  67 PRO PRO E . n 
E 1 68  VAL 68  68  68 VAL VAL E . n 
E 1 69  SER 69  69  ?  ?   ?   E . n 
E 1 70  HIS 70  70  ?  ?   ?   E . n 
E 1 71  HIS 71  71  ?  ?   ?   E . n 
E 1 72  SER 72  72  ?  ?   ?   E . n 
E 1 73  ASN 73  73  ?  ?   ?   E . n 
E 1 74  ASN 74  74  ?  ?   ?   E . n 
E 1 75  ALA 75  75  ?  ?   ?   E . n 
E 1 76  GLY 76  76  ?  ?   ?   E . n 
E 1 77  GLY 77  77  ?  ?   ?   E . n 
E 1 78  GLY 78  78  ?  ?   ?   E . n 
E 1 79  THR 79  79  ?  ?   ?   E . n 
E 1 80  SER 80  80  ?  ?   ?   E . n 
E 1 81  SER 81  81  ?  ?   ?   E . n 
E 1 82  ASN 82  82  ?  ?   ?   E . n 
E 1 83  TYR 83  83  ?  ?   ?   E . n 
E 1 84  HIS 84  84  ?  ?   ?   E . n 
E 1 85  HIS 85  85  ?  ?   ?   E . n 
E 1 86  GLY 86  86  ?  ?   ?   E . n 
E 1 87  SER 87  87  ?  ?   ?   E . n 
E 1 88  SER 88  88  ?  ?   ?   E . n 
E 1 89  ALA 89  89  ?  ?   ?   E . n 
E 1 90  GLN 90  90  ?  ?   ?   E . n 
E 1 91  ASN 91  91  ?  ?   ?   E . n 
E 1 92  THR 92  92  ?  ?   ?   E . n 
E 1 93  SER 93  93  ?  ?   ?   E . n 
E 1 94  ALA 94  94  ?  ?   ?   E . n 
E 1 95  GLN 95  95  ?  ?   ?   E . n 
E 1 96  GLN 96  96  ?  ?   ?   E . n 
E 1 97  ASP 97  97  ?  ?   ?   E . n 
E 1 98  SER 98  98  ?  ?   ?   E . n 
E 1 99  GLU 99  99  ?  ?   ?   E . n 
E 1 100 GLU 100 100 ?  ?   ?   E . n 
E 1 101 THR 101 101 ?  ?   ?   E . n 
E 1 102 GLU 102 102 ?  ?   ?   E . n 
F 1 1   MET 1   1   ?  ?   ?   F . n 
F 1 2   ALA 2   2   ?  ?   ?   F . n 
F 1 3   LYS 3   3   ?  ?   ?   F . n 
F 1 4   GLY 4   4   ?  ?   ?   F . n 
F 1 5   GLN 5   5   5  GLN GLN F . n 
F 1 6   SER 6   6   6  SER SER F . n 
F 1 7   LEU 7   7   7  LEU LEU F . n 
F 1 8   GLN 8   8   8  GLN GLN F . n 
F 1 9   ASP 9   9   9  ASP ASP F . n 
F 1 10  PRO 10  10  10 PRO PRO F . n 
F 1 11  PHE 11  11  11 PHE PHE F . n 
F 1 12  LEU 12  12  12 LEU LEU F . n 
F 1 13  ASN 13  13  13 ASN ASN F . n 
F 1 14  ALA 14  14  14 ALA ALA F . n 
F 1 15  LEU 15  15  15 LEU LEU F . n 
F 1 16  ARG 16  16  16 ARG ARG F . n 
F 1 17  ARG 17  17  17 ARG ARG F . n 
F 1 18  GLU 18  18  18 GLU GLU F . n 
F 1 19  ARG 19  19  19 ARG ARG F . n 
F 1 20  VAL 20  20  20 VAL VAL F . n 
F 1 21  PRO 21  21  21 PRO PRO F . n 
F 1 22  ALA 22  22  22 ALA ALA F . n 
F 1 23  SER 23  23  23 SER SER F . n 
F 1 24  ILE 24  24  24 ILE ILE F . n 
F 1 25  TYR 25  25  25 TYR TYR F . n 
F 1 26  LEU 26  26  26 LEU LEU F . n 
F 1 27  VAL 27  27  27 VAL VAL F . n 
F 1 28  ASN 28  28  28 ASN ASN F . n 
F 1 29  GLY 29  29  29 GLY GLY F . n 
F 1 30  ILE 30  30  30 ILE ILE F . n 
F 1 31  LYS 31  31  31 LYS LYS F . n 
F 1 32  LEU 32  32  32 LEU LEU F . n 
F 1 33  GLN 33  33  33 GLN GLN F . n 
F 1 34  GLY 34  34  34 GLY GLY F . n 
F 1 35  GLN 35  35  35 GLN GLN F . n 
F 1 36  ILE 36  36  36 ILE ILE F . n 
F 1 37  GLU 37  37  37 GLU GLU F . n 
F 1 38  SER 38  38  38 SER SER F . n 
F 1 39  PHE 39  39  39 PHE PHE F . n 
F 1 40  ASP 40  40  40 ASP ASP F . n 
F 1 41  GLN 41  41  41 GLN GLN F . n 
F 1 42  PHE 42  42  42 PHE PHE F . n 
F 1 43  VAL 43  43  43 VAL VAL F . n 
F 1 44  ILE 44  44  44 ILE ILE F . n 
F 1 45  LEU 45  45  45 LEU LEU F . n 
F 1 46  LEU 46  46  46 LEU LEU F . n 
F 1 47  LYS 47  47  47 LYS LYS F . n 
F 1 48  ASN 48  48  48 ASN ASN F . n 
F 1 49  THR 49  49  49 THR THR F . n 
F 1 50  VAL 50  50  50 VAL VAL F . n 
F 1 51  SER 51  51  51 SER SER F . n 
F 1 52  GLN 52  52  52 GLN GLN F . n 
F 1 53  MET 53  53  53 MET MET F . n 
F 1 54  VAL 54  54  54 VAL VAL F . n 
F 1 55  TYR 55  55  55 TYR TYR F . n 
F 1 56  LYS 56  56  56 LYS LYS F . n 
F 1 57  HIS 57  57  57 HIS HIS F . n 
F 1 58  ALA 58  58  58 ALA ALA F . n 
F 1 59  ILE 59  59  59 ILE ILE F . n 
F 1 60  SER 60  60  60 SER SER F . n 
F 1 61  THR 61  61  61 THR THR F . n 
F 1 62  VAL 62  62  62 VAL VAL F . n 
F 1 63  VAL 63  63  63 VAL VAL F . n 
F 1 64  PRO 64  64  64 PRO PRO F . n 
F 1 65  SER 65  65  65 SER SER F . n 
F 1 66  ARG 66  66  66 ARG ARG F . n 
F 1 67  PRO 67  67  67 PRO PRO F . n 
F 1 68  VAL 68  68  68 VAL VAL F . n 
F 1 69  SER 69  69  ?  ?   ?   F . n 
F 1 70  HIS 70  70  ?  ?   ?   F . n 
F 1 71  HIS 71  71  ?  ?   ?   F . n 
F 1 72  SER 72  72  ?  ?   ?   F . n 
F 1 73  ASN 73  73  ?  ?   ?   F . n 
F 1 74  ASN 74  74  ?  ?   ?   F . n 
F 1 75  ALA 75  75  ?  ?   ?   F . n 
F 1 76  GLY 76  76  ?  ?   ?   F . n 
F 1 77  GLY 77  77  ?  ?   ?   F . n 
F 1 78  GLY 78  78  ?  ?   ?   F . n 
F 1 79  THR 79  79  ?  ?   ?   F . n 
F 1 80  SER 80  80  ?  ?   ?   F . n 
F 1 81  SER 81  81  ?  ?   ?   F . n 
F 1 82  ASN 82  82  ?  ?   ?   F . n 
F 1 83  TYR 83  83  ?  ?   ?   F . n 
F 1 84  HIS 84  84  ?  ?   ?   F . n 
F 1 85  HIS 85  85  ?  ?   ?   F . n 
F 1 86  GLY 86  86  ?  ?   ?   F . n 
F 1 87  SER 87  87  ?  ?   ?   F . n 
F 1 88  SER 88  88  ?  ?   ?   F . n 
F 1 89  ALA 89  89  ?  ?   ?   F . n 
F 1 90  GLN 90  90  ?  ?   ?   F . n 
F 1 91  ASN 91  91  ?  ?   ?   F . n 
F 1 92  THR 92  92  ?  ?   ?   F . n 
F 1 93  SER 93  93  ?  ?   ?   F . n 
F 1 94  ALA 94  94  ?  ?   ?   F . n 
F 1 95  GLN 95  95  ?  ?   ?   F . n 
F 1 96  GLN 96  96  ?  ?   ?   F . n 
F 1 97  ASP 97  97  ?  ?   ?   F . n 
F 1 98  SER 98  98  ?  ?   ?   F . n 
F 1 99  GLU 99  99  ?  ?   ?   F . n 
F 1 100 GLU 100 100 ?  ?   ?   F . n 
F 1 101 THR 101 101 ?  ?   ?   F . n 
F 1 102 GLU 102 102 ?  ?   ?   F . n 
G 2 1   A   1   1   1  A   A   Q . n 
G 2 2   A   2   2   2  A   A   Q . n 
G 2 3   A   3   3   3  A   A   Q . n 
G 2 4   A   4   4   4  A   A   Q . n 
G 2 5   A   5   5   5  A   A   Q . n 
G 2 6   A   6   6   6  A   A   Q . n 
G 2 7   A   7   7   7  A   A   Q . n 
G 2 8   A   8   8   8  A   A   Q . n 
G 2 9   A   9   9   9  A   A   Q . n 
G 2 10  A   10  10  10 A   A   Q . n 
G 2 11  A   11  11  11 A   A   Q . n 
G 2 12  A   12  12  12 A   A   Q . n 
G 2 13  A   13  13  13 A   A   Q . n 
G 2 14  A   14  14  14 A   A   Q . n 
G 2 15  A   15  15  15 A   A   Q . n 
G 2 16  A   16  16  16 A   A   Q . n 
G 2 17  A   17  17  17 A   A   Q . n 
G 2 18  A   18  18  18 A   A   Q . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
H 3 HOH 1  201 56  HOH HOH A . 
H 3 HOH 2  202 104 HOH HOH A . 
H 3 HOH 3  203 30  HOH HOH A . 
H 3 HOH 4  204 7   HOH HOH A . 
H 3 HOH 5  205 391 HOH HOH A . 
H 3 HOH 6  206 95  HOH HOH A . 
H 3 HOH 7  207 39  HOH HOH A . 
H 3 HOH 8  208 117 HOH HOH A . 
H 3 HOH 9  209 354 HOH HOH A . 
H 3 HOH 10 210 14  HOH HOH A . 
H 3 HOH 11 211 267 HOH HOH A . 
H 3 HOH 12 212 282 HOH HOH A . 
H 3 HOH 13 213 55  HOH HOH A . 
H 3 HOH 14 214 454 HOH HOH A . 
H 3 HOH 15 215 340 HOH HOH A . 
H 3 HOH 16 216 46  HOH HOH A . 
H 3 HOH 17 217 384 HOH HOH A . 
H 3 HOH 18 218 67  HOH HOH A . 
H 3 HOH 19 219 108 HOH HOH A . 
H 3 HOH 20 220 53  HOH HOH A . 
H 3 HOH 21 221 44  HOH HOH A . 
H 3 HOH 22 222 43  HOH HOH A . 
H 3 HOH 23 223 17  HOH HOH A . 
H 3 HOH 24 224 1   HOH HOH A . 
H 3 HOH 25 225 101 HOH HOH A . 
H 3 HOH 26 226 383 HOH HOH A . 
H 3 HOH 27 227 51  HOH HOH A . 
H 3 HOH 28 228 52  HOH HOH A . 
H 3 HOH 29 229 422 HOH HOH A . 
H 3 HOH 30 230 45  HOH HOH A . 
H 3 HOH 31 231 298 HOH HOH A . 
H 3 HOH 32 232 295 HOH HOH A . 
H 3 HOH 33 233 395 HOH HOH A . 
H 3 HOH 34 234 270 HOH HOH A . 
H 3 HOH 35 235 257 HOH HOH A . 
H 3 HOH 36 236 365 HOH HOH A . 
I 3 HOH 1  201 15  HOH HOH B . 
I 3 HOH 2  202 41  HOH HOH B . 
I 3 HOH 3  203 40  HOH HOH B . 
I 3 HOH 4  204 10  HOH HOH B . 
I 3 HOH 5  205 241 HOH HOH B . 
I 3 HOH 6  206 83  HOH HOH B . 
I 3 HOH 7  207 96  HOH HOH B . 
I 3 HOH 8  208 123 HOH HOH B . 
I 3 HOH 9  209 65  HOH HOH B . 
I 3 HOH 10 210 9   HOH HOH B . 
I 3 HOH 11 211 411 HOH HOH B . 
I 3 HOH 12 212 114 HOH HOH B . 
I 3 HOH 13 213 145 HOH HOH B . 
I 3 HOH 14 214 262 HOH HOH B . 
I 3 HOH 15 215 286 HOH HOH B . 
I 3 HOH 16 216 439 HOH HOH B . 
I 3 HOH 17 217 244 HOH HOH B . 
I 3 HOH 18 218 79  HOH HOH B . 
I 3 HOH 19 219 72  HOH HOH B . 
I 3 HOH 20 220 57  HOH HOH B . 
I 3 HOH 21 221 443 HOH HOH B . 
I 3 HOH 22 222 393 HOH HOH B . 
I 3 HOH 23 223 85  HOH HOH B . 
I 3 HOH 24 224 394 HOH HOH B . 
I 3 HOH 25 225 199 HOH HOH B . 
I 3 HOH 26 226 467 HOH HOH B . 
I 3 HOH 27 227 409 HOH HOH B . 
I 3 HOH 28 228 372 HOH HOH B . 
I 3 HOH 29 229 466 HOH HOH B . 
I 3 HOH 30 230 306 HOH HOH B . 
I 3 HOH 31 231 427 HOH HOH B . 
I 3 HOH 32 232 450 HOH HOH B . 
I 3 HOH 33 233 22  HOH HOH B . 
I 3 HOH 34 234 321 HOH HOH B . 
I 3 HOH 35 235 360 HOH HOH B . 
I 3 HOH 36 236 288 HOH HOH B . 
I 3 HOH 37 237 296 HOH HOH B . 
I 3 HOH 38 238 149 HOH HOH B . 
I 3 HOH 39 239 437 HOH HOH B . 
J 3 HOH 1  201 412 HOH HOH C . 
J 3 HOH 2  202 357 HOH HOH C . 
J 3 HOH 3  203 367 HOH HOH C . 
J 3 HOH 4  204 109 HOH HOH C . 
J 3 HOH 5  205 71  HOH HOH C . 
J 3 HOH 6  206 185 HOH HOH C . 
J 3 HOH 7  207 59  HOH HOH C . 
J 3 HOH 8  208 19  HOH HOH C . 
J 3 HOH 9  209 42  HOH HOH C . 
J 3 HOH 10 210 26  HOH HOH C . 
J 3 HOH 11 211 322 HOH HOH C . 
J 3 HOH 12 212 214 HOH HOH C . 
J 3 HOH 13 213 309 HOH HOH C . 
J 3 HOH 14 214 429 HOH HOH C . 
J 3 HOH 15 215 247 HOH HOH C . 
J 3 HOH 16 216 370 HOH HOH C . 
J 3 HOH 17 217 34  HOH HOH C . 
J 3 HOH 18 218 98  HOH HOH C . 
J 3 HOH 19 219 140 HOH HOH C . 
J 3 HOH 20 220 406 HOH HOH C . 
J 3 HOH 21 221 112 HOH HOH C . 
J 3 HOH 22 222 319 HOH HOH C . 
J 3 HOH 23 223 281 HOH HOH C . 
J 3 HOH 24 224 148 HOH HOH C . 
J 3 HOH 25 225 245 HOH HOH C . 
J 3 HOH 26 226 255 HOH HOH C . 
J 3 HOH 27 227 303 HOH HOH C . 
J 3 HOH 28 228 49  HOH HOH C . 
J 3 HOH 29 229 205 HOH HOH C . 
J 3 HOH 30 230 250 HOH HOH C . 
J 3 HOH 31 231 50  HOH HOH C . 
K 3 HOH 1  201 259 HOH HOH D . 
K 3 HOH 2  202 103 HOH HOH D . 
K 3 HOH 3  203 369 HOH HOH D . 
K 3 HOH 4  204 273 HOH HOH D . 
K 3 HOH 5  205 308 HOH HOH D . 
K 3 HOH 6  206 418 HOH HOH D . 
K 3 HOH 7  207 60  HOH HOH D . 
K 3 HOH 8  208 106 HOH HOH D . 
K 3 HOH 9  209 230 HOH HOH D . 
K 3 HOH 10 210 63  HOH HOH D . 
K 3 HOH 11 211 278 HOH HOH D . 
K 3 HOH 12 212 130 HOH HOH D . 
K 3 HOH 13 213 404 HOH HOH D . 
K 3 HOH 14 214 76  HOH HOH D . 
K 3 HOH 15 215 131 HOH HOH D . 
K 3 HOH 16 216 110 HOH HOH D . 
K 3 HOH 17 217 291 HOH HOH D . 
K 3 HOH 18 218 6   HOH HOH D . 
K 3 HOH 19 219 92  HOH HOH D . 
K 3 HOH 20 220 16  HOH HOH D . 
K 3 HOH 21 221 191 HOH HOH D . 
K 3 HOH 22 222 248 HOH HOH D . 
K 3 HOH 23 223 107 HOH HOH D . 
K 3 HOH 24 224 325 HOH HOH D . 
K 3 HOH 25 225 359 HOH HOH D . 
K 3 HOH 26 226 37  HOH HOH D . 
K 3 HOH 27 227 141 HOH HOH D . 
K 3 HOH 28 228 324 HOH HOH D . 
K 3 HOH 29 229 210 HOH HOH D . 
K 3 HOH 30 230 310 HOH HOH D . 
K 3 HOH 31 231 227 HOH HOH D . 
K 3 HOH 32 232 260 HOH HOH D . 
K 3 HOH 33 233 211 HOH HOH D . 
K 3 HOH 34 234 166 HOH HOH D . 
K 3 HOH 35 235 150 HOH HOH D . 
K 3 HOH 36 236 113 HOH HOH D . 
K 3 HOH 37 237 398 HOH HOH D . 
K 3 HOH 38 238 386 HOH HOH D . 
L 3 HOH 1  201 62  HOH HOH E . 
L 3 HOH 2  202 233 HOH HOH E . 
L 3 HOH 3  203 336 HOH HOH E . 
L 3 HOH 4  204 69  HOH HOH E . 
L 3 HOH 5  205 4   HOH HOH E . 
L 3 HOH 6  206 246 HOH HOH E . 
L 3 HOH 7  207 28  HOH HOH E . 
L 3 HOH 8  208 458 HOH HOH E . 
L 3 HOH 9  209 64  HOH HOH E . 
L 3 HOH 10 210 217 HOH HOH E . 
L 3 HOH 11 211 302 HOH HOH E . 
L 3 HOH 12 212 2   HOH HOH E . 
L 3 HOH 13 213 48  HOH HOH E . 
L 3 HOH 14 214 364 HOH HOH E . 
L 3 HOH 15 215 102 HOH HOH E . 
L 3 HOH 16 216 256 HOH HOH E . 
L 3 HOH 17 217 440 HOH HOH E . 
L 3 HOH 18 218 125 HOH HOH E . 
L 3 HOH 19 219 105 HOH HOH E . 
L 3 HOH 20 220 387 HOH HOH E . 
L 3 HOH 21 221 420 HOH HOH E . 
L 3 HOH 22 222 143 HOH HOH E . 
L 3 HOH 23 223 448 HOH HOH E . 
L 3 HOH 24 224 128 HOH HOH E . 
L 3 HOH 25 225 115 HOH HOH E . 
L 3 HOH 26 226 299 HOH HOH E . 
L 3 HOH 27 227 54  HOH HOH E . 
L 3 HOH 28 228 219 HOH HOH E . 
L 3 HOH 29 229 320 HOH HOH E . 
L 3 HOH 30 230 237 HOH HOH E . 
L 3 HOH 31 231 225 HOH HOH E . 
L 3 HOH 32 232 82  HOH HOH E . 
L 3 HOH 33 233 212 HOH HOH E . 
L 3 HOH 34 234 153 HOH HOH E . 
L 3 HOH 35 235 300 HOH HOH E . 
L 3 HOH 36 236 81  HOH HOH E . 
L 3 HOH 37 237 146 HOH HOH E . 
L 3 HOH 38 238 159 HOH HOH E . 
L 3 HOH 39 239 209 HOH HOH E . 
L 3 HOH 40 240 187 HOH HOH E . 
L 3 HOH 41 241 189 HOH HOH E . 
M 3 HOH 1  201 38  HOH HOH F . 
M 3 HOH 2  202 36  HOH HOH F . 
M 3 HOH 3  203 312 HOH HOH F . 
M 3 HOH 4  204 344 HOH HOH F . 
M 3 HOH 5  205 80  HOH HOH F . 
M 3 HOH 6  206 329 HOH HOH F . 
M 3 HOH 7  207 226 HOH HOH F . 
M 3 HOH 8  208 232 HOH HOH F . 
M 3 HOH 9  209 461 HOH HOH F . 
M 3 HOH 10 210 307 HOH HOH F . 
M 3 HOH 11 211 31  HOH HOH F . 
M 3 HOH 12 212 222 HOH HOH F . 
M 3 HOH 13 213 139 HOH HOH F . 
M 3 HOH 14 214 58  HOH HOH F . 
M 3 HOH 15 215 451 HOH HOH F . 
M 3 HOH 16 216 408 HOH HOH F . 
M 3 HOH 17 217 25  HOH HOH F . 
M 3 HOH 18 218 5   HOH HOH F . 
M 3 HOH 19 219 68  HOH HOH F . 
M 3 HOH 20 220 75  HOH HOH F . 
M 3 HOH 21 221 285 HOH HOH F . 
M 3 HOH 22 222 385 HOH HOH F . 
M 3 HOH 23 223 116 HOH HOH F . 
M 3 HOH 24 224 124 HOH HOH F . 
M 3 HOH 25 225 99  HOH HOH F . 
M 3 HOH 26 226 390 HOH HOH F . 
M 3 HOH 27 227 326 HOH HOH F . 
M 3 HOH 28 228 469 HOH HOH F . 
M 3 HOH 29 229 331 HOH HOH F . 
M 3 HOH 30 230 337 HOH HOH F . 
M 3 HOH 31 231 238 HOH HOH F . 
M 3 HOH 32 232 339 HOH HOH F . 
M 3 HOH 33 233 163 HOH HOH F . 
M 3 HOH 34 234 118 HOH HOH F . 
M 3 HOH 35 235 275 HOH HOH F . 
M 3 HOH 36 236 151 HOH HOH F . 
M 3 HOH 37 237 401 HOH HOH F . 
M 3 HOH 38 238 161 HOH HOH F . 
M 3 HOH 39 239 158 HOH HOH F . 
M 3 HOH 40 240 332 HOH HOH F . 
M 3 HOH 41 241 334 HOH HOH F . 
M 3 HOH 42 242 119 HOH HOH F . 
M 3 HOH 43 243 380 HOH HOH F . 
N 3 HOH 1  101 268 HOH HOH Q . 
N 3 HOH 2  102 253 HOH HOH Q . 
N 3 HOH 3  103 70  HOH HOH Q . 
N 3 HOH 4  104 349 HOH HOH Q . 
N 3 HOH 5  105 86  HOH HOH Q . 
N 3 HOH 6  106 407 HOH HOH Q . 
N 3 HOH 7  107 198 HOH HOH Q . 
N 3 HOH 8  108 78  HOH HOH Q . 
N 3 HOH 9  109 74  HOH HOH Q . 
N 3 HOH 10 110 3   HOH HOH Q . 
N 3 HOH 11 111 91  HOH HOH Q . 
N 3 HOH 12 112 353 HOH HOH Q . 
N 3 HOH 13 113 18  HOH HOH Q . 
N 3 HOH 14 114 206 HOH HOH Q . 
N 3 HOH 15 115 468 HOH HOH Q . 
N 3 HOH 16 116 138 HOH HOH Q . 
N 3 HOH 17 117 73  HOH HOH Q . 
N 3 HOH 18 118 90  HOH HOH Q . 
N 3 HOH 19 119 77  HOH HOH Q . 
N 3 HOH 20 120 8   HOH HOH Q . 
N 3 HOH 21 121 120 HOH HOH Q . 
N 3 HOH 22 122 361 HOH HOH Q . 
N 3 HOH 23 123 366 HOH HOH Q . 
N 3 HOH 24 124 290 HOH HOH Q . 
N 3 HOH 25 125 405 HOH HOH Q . 
N 3 HOH 26 126 132 HOH HOH Q . 
N 3 HOH 27 127 323 HOH HOH Q . 
N 3 HOH 28 128 377 HOH HOH Q . 
N 3 HOH 29 129 33  HOH HOH Q . 
N 3 HOH 30 130 61  HOH HOH Q . 
N 3 HOH 31 131 196 HOH HOH Q . 
N 3 HOH 32 132 20  HOH HOH Q . 
N 3 HOH 33 133 21  HOH HOH Q . 
N 3 HOH 34 134 29  HOH HOH Q . 
N 3 HOH 35 135 93  HOH HOH Q . 
N 3 HOH 36 136 373 HOH HOH Q . 
N 3 HOH 37 137 13  HOH HOH Q . 
N 3 HOH 38 138 442 HOH HOH Q . 
N 3 HOH 39 139 12  HOH HOH Q . 
N 3 HOH 40 140 11  HOH HOH Q . 
N 3 HOH 41 141 266 HOH HOH Q . 
N 3 HOH 42 142 358 HOH HOH Q . 
N 3 HOH 43 143 89  HOH HOH Q . 
N 3 HOH 44 144 213 HOH HOH Q . 
N 3 HOH 45 145 289 HOH HOH Q . 
N 3 HOH 46 146 231 HOH HOH Q . 
N 3 HOH 47 147 66  HOH HOH Q . 
N 3 HOH 48 148 164 HOH HOH Q . 
N 3 HOH 49 149 287 HOH HOH Q . 
N 3 HOH 50 150 465 HOH HOH Q . 
N 3 HOH 51 151 436 HOH HOH Q . 
N 3 HOH 52 152 154 HOH HOH Q . 
N 3 HOH 53 153 379 HOH HOH Q . 
N 3 HOH 54 154 414 HOH HOH Q . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? '(1.20.1_4487: ???)' 1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? xia2   ? ? ? .                    2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .                    3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .                    4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   104.64 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9H45 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     116.250 
_cell.length_a_esd                 ? 
_cell.length_b                     67.150 
_cell.length_b_esd                 ? 
_cell.length_c                     84.580 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        24 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9H45 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                5 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'C 1 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9H45 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.19 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          43.94 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '15 %v/v PEGSH 0.15 M NH4 Acet 0.1 M Na3 Cit' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 XE 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2024-09-23 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.9763 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'DIAMOND BEAMLINE I03' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.9763 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   I03 
_diffrn_source.pdbx_synchrotron_site       Diamond 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9H45 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.08 
_reflns.d_resolution_low                               57.66 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     37712 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.1 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                6.9 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          3.3 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.551 
_reflns.pdbx_Rpim_I_all                                0.209 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       258949 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.968 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.509 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.08 
_reflns_shell.d_res_low                                     2.12 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           12714 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1912 
_reflns_shell.percent_possible_obs                          99.7 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               6.6 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     1.5 
_reflns_shell.pdbx_Rrim_I_all                               2.196 
_reflns_shell.pdbx_Rpim_I_all                               0.841 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.246 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  2.025 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9H45 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.08 
_refine.ls_d_res_low                             56.24 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     37680 
_refine.ls_number_reflns_R_free                  1879 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.05 
_refine.ls_percent_reflns_R_free                 4.99 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2764 
_refine.ls_R_factor_R_free                       0.3233 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2740 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.10 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.90 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 36.12 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.41 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.pdbx_number_atoms_protein        3025 
_refine_hist.pdbx_number_atoms_nucleic_acid   396 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.number_atoms_solvent             282 
_refine_hist.number_atoms_total               3703 
_refine_hist.d_res_high                       2.08 
_refine_hist.d_res_low                        56.24 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.003 ? ?   ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.679 ? ?   ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 8.285 ? 653 ? f_dihedral_angle_d ? ? 
'X-RAY DIFFRACTION' ? 0.047 ? 621 ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.007 ? 592 ? f_plane_restr      ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.08 2.14  . . 158 2742 100.00 . . . . 0.3420 . . . . . . . . . . . 0.4008 
'X-RAY DIFFRACTION' 2.14 2.20  . . 159 2705 99.00  . . . . 0.3225 . . . . . . . . . . . 0.3226 
'X-RAY DIFFRACTION' 2.20 2.27  . . 144 2737 100.00 . . . . 0.3280 . . . . . . . . . . . 0.3710 
'X-RAY DIFFRACTION' 2.27 2.35  . . 137 2795 100.00 . . . . 0.3136 . . . . . . . . . . . 0.3741 
'X-RAY DIFFRACTION' 2.35 2.45  . . 155 2754 100.00 . . . . 0.3152 . . . . . . . . . . . 0.3949 
'X-RAY DIFFRACTION' 2.45 2.56  . . 157 2739 100.00 . . . . 0.3270 . . . . . . . . . . . 0.3708 
'X-RAY DIFFRACTION' 2.56 2.69  . . 149 2778 100.00 . . . . 0.3354 . . . . . . . . . . . 0.4026 
'X-RAY DIFFRACTION' 2.69 2.86  . . 137 2762 100.00 . . . . 0.2880 . . . . . . . . . . . 0.3556 
'X-RAY DIFFRACTION' 2.86 3.08  . . 139 2790 100.00 . . . . 0.2942 . . . . . . . . . . . 0.3027 
'X-RAY DIFFRACTION' 3.08 3.39  . . 148 2768 100.00 . . . . 0.2435 . . . . . . . . . . . 0.3086 
'X-RAY DIFFRACTION' 3.39 3.88  . . 133 2797 100.00 . . . . 0.2309 . . . . . . . . . . . 0.2548 
'X-RAY DIFFRACTION' 3.88 4.89  . . 125 2805 100.00 . . . . 0.1985 . . . . . . . . . . . 0.2447 
'X-RAY DIFFRACTION' 4.89 56.24 . . 138 2629 91.00  . . . . 0.2621 . . . . . . . . . . . 0.3269 
# 
_struct.entry_id                     9H45 
_struct.title                        'Crystal Structure of Hfq V22A' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9H45 
_struct_keywords.text            'RNA-chaperone, HYDROLASE' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 1 ? 
D N N 1 ? 
E N N 1 ? 
F N N 1 ? 
G N N 2 ? 
H N N 3 ? 
I N N 3 ? 
J N N 3 ? 
K N N 3 ? 
L N N 3 ? 
M N N 3 ? 
N N N 3 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP HFQ_ECOLI P0A6X3 ? 1 
;MAKGQSLQDPFLNALRRERVPVSIYLVNGIKLQGQIESFDQFVILLKNTVSQMVYKHAISTVVPSRPVSHHSNNAGGGTS
SNYHHGSSAQNTSAQQDSEETE
;
1 
2 PDB 9H45      9H45   ? 2 ? 1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9H45 A 1 ? 102 ? P0A6X3 1 ? 102 ? 1 102 
2 1 9H45 B 1 ? 102 ? P0A6X3 1 ? 102 ? 1 102 
3 1 9H45 C 1 ? 102 ? P0A6X3 1 ? 102 ? 1 102 
4 1 9H45 D 1 ? 102 ? P0A6X3 1 ? 102 ? 1 102 
5 1 9H45 E 1 ? 102 ? P0A6X3 1 ? 102 ? 1 102 
6 1 9H45 F 1 ? 102 ? P0A6X3 1 ? 102 ? 1 102 
7 2 9H45 Q 1 ? 18  ? 9H45   1 ? 18  ? 1 18  
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9H45 ALA A 22 ? UNP P0A6X3 VAL 22 'engineered mutation' 22 1 
2 9H45 ALA B 22 ? UNP P0A6X3 VAL 22 'engineered mutation' 22 2 
3 9H45 ALA C 22 ? UNP P0A6X3 VAL 22 'engineered mutation' 22 3 
4 9H45 ALA D 22 ? UNP P0A6X3 VAL 22 'engineered mutation' 22 4 
5 9H45 ALA E 22 ? UNP P0A6X3 VAL 22 'engineered mutation' 22 5 
6 9H45 ALA F 22 ? UNP P0A6X3 VAL 22 'engineered mutation' 22 6 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   heptameric 
_pdbx_struct_assembly.oligomeric_count     7 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 13160 ? 
1 MORE         -66   ? 
1 'SSA (A^2)'  18400 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L,M,N 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 LEU A 7  ? ARG A 19 ? LEU A 7  ARG A 19 1 ? 13 
HELX_P HELX_P2 AA2 LEU B 7  ? ARG B 19 ? LEU B 7  ARG B 19 1 ? 13 
HELX_P HELX_P3 AA3 GLN C 8  ? GLU C 18 ? GLN C 8  GLU C 18 1 ? 11 
HELX_P HELX_P4 AA4 GLN D 8  ? ASN D 13 ? GLN D 8  ASN D 13 1 ? 6  
HELX_P HELX_P5 AA5 LEU D 15 ? ARG D 17 ? LEU D 15 ARG D 17 5 ? 3  
HELX_P HELX_P6 AA6 LEU E 7  ? ARG E 19 ? LEU E 7  ARG E 19 1 ? 13 
HELX_P HELX_P7 AA7 GLN F 8  ? GLU F 18 ? GLN F 8  GLU F 18 1 ? 11 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_sheet.id               AA1 
_struct_sheet.type             ? 
_struct_sheet.number_strands   31 
_struct_sheet.details          ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1  2  ? anti-parallel 
AA1 2  3  ? anti-parallel 
AA1 3  4  ? anti-parallel 
AA1 4  5  ? anti-parallel 
AA1 5  6  ? anti-parallel 
AA1 6  7  ? anti-parallel 
AA1 7  8  ? anti-parallel 
AA1 8  9  ? anti-parallel 
AA1 9  10 ? anti-parallel 
AA1 10 11 ? anti-parallel 
AA1 11 12 ? anti-parallel 
AA1 12 13 ? anti-parallel 
AA1 13 14 ? anti-parallel 
AA1 14 15 ? anti-parallel 
AA1 15 16 ? anti-parallel 
AA1 16 17 ? anti-parallel 
AA1 17 18 ? anti-parallel 
AA1 18 19 ? anti-parallel 
AA1 19 20 ? anti-parallel 
AA1 20 21 ? anti-parallel 
AA1 21 22 ? anti-parallel 
AA1 22 23 ? anti-parallel 
AA1 23 24 ? anti-parallel 
AA1 24 25 ? anti-parallel 
AA1 25 26 ? anti-parallel 
AA1 26 27 ? anti-parallel 
AA1 27 28 ? anti-parallel 
AA1 28 29 ? anti-parallel 
AA1 29 30 ? anti-parallel 
AA1 30 31 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1  ALA A 22 ? LEU A 26 ? ALA A 22 LEU A 26 
AA1 2  LYS A 31 ? PHE A 39 ? LYS A 31 PHE A 39 
AA1 3  VAL A 43 ? LYS A 47 ? VAL A 43 LYS A 47 
AA1 4  SER A 51 ? TYR A 55 ? SER A 51 TYR A 55 
AA1 5  ILE B 59 ? PRO B 64 ? ILE B 59 PRO B 64 
AA1 6  ALA B 22 ? LEU B 26 ? ALA B 22 LEU B 26 
AA1 7  LYS B 31 ? PHE B 39 ? LYS B 31 PHE B 39 
AA1 8  VAL B 43 ? LYS B 47 ? VAL B 43 LYS B 47 
AA1 9  SER B 51 ? TYR B 55 ? SER B 51 TYR B 55 
AA1 10 ILE D 59 ? PRO D 64 ? ILE D 59 PRO D 64 
AA1 11 ALA D 22 ? LEU D 26 ? ALA D 22 LEU D 26 
AA1 12 LYS D 31 ? PHE D 39 ? LYS D 31 PHE D 39 
AA1 13 VAL D 43 ? LYS D 47 ? VAL D 43 LYS D 47 
AA1 14 SER D 51 ? TYR D 55 ? SER D 51 TYR D 55 
AA1 15 ILE F 59 ? PRO F 64 ? ILE F 59 PRO F 64 
AA1 16 ALA F 22 ? LEU F 26 ? ALA F 22 LEU F 26 
AA1 17 LYS F 31 ? PHE F 39 ? LYS F 31 PHE F 39 
AA1 18 VAL F 43 ? LYS F 47 ? VAL F 43 LYS F 47 
AA1 19 SER F 51 ? TYR F 55 ? SER F 51 TYR F 55 
AA1 20 ILE E 59 ? PRO E 64 ? ILE E 59 PRO E 64 
AA1 21 ALA E 22 ? LEU E 26 ? ALA E 22 LEU E 26 
AA1 22 LYS E 31 ? PHE E 39 ? LYS E 31 PHE E 39 
AA1 23 VAL E 43 ? LYS E 47 ? VAL E 43 LYS E 47 
AA1 24 SER E 51 ? TYR E 55 ? SER E 51 TYR E 55 
AA1 25 ILE C 59 ? PRO C 64 ? ILE C 59 PRO C 64 
AA1 26 ALA C 22 ? LEU C 26 ? ALA C 22 LEU C 26 
AA1 27 LYS C 31 ? PHE C 39 ? LYS C 31 PHE C 39 
AA1 28 VAL C 43 ? LYS C 47 ? VAL C 43 LYS C 47 
AA1 29 SER C 51 ? TYR C 55 ? SER C 51 TYR C 55 
AA1 30 ILE A 59 ? PRO A 64 ? ILE A 59 PRO A 64 
AA1 31 ALA A 22 ? LEU A 26 ? ALA A 22 LEU A 26 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1  2  N ILE A 24 ? N ILE A 24 O LEU A 32 ? O LEU A 32 
AA1 2  3  N GLU A 37 ? N GLU A 37 O LEU A 45 ? O LEU A 45 
AA1 3  4  N ILE A 44 ? N ILE A 44 O VAL A 54 ? O VAL A 54 
AA1 4  5  N MET A 53 ? N MET A 53 O VAL B 62 ? O VAL B 62 
AA1 5  6  O SER B 60 ? O SER B 60 N TYR B 25 ? N TYR B 25 
AA1 6  7  N ILE B 24 ? N ILE B 24 O LEU B 32 ? O LEU B 32 
AA1 7  8  N GLU B 37 ? N GLU B 37 O LEU B 45 ? O LEU B 45 
AA1 8  9  N ILE B 44 ? N ILE B 44 O VAL B 54 ? O VAL B 54 
AA1 9  10 N MET B 53 ? N MET B 53 O VAL D 62 ? O VAL D 62 
AA1 10 11 O THR D 61 ? O THR D 61 N TYR D 25 ? N TYR D 25 
AA1 11 12 N ALA D 22 ? N ALA D 22 O GLY D 34 ? O GLY D 34 
AA1 12 13 N GLU D 37 ? N GLU D 37 O LEU D 45 ? O LEU D 45 
AA1 13 14 N LEU D 46 ? N LEU D 46 O GLN D 52 ? O GLN D 52 
AA1 14 15 N TYR D 55 ? N TYR D 55 O SER F 60 ? O SER F 60 
AA1 15 16 O THR F 61 ? O THR F 61 N TYR F 25 ? N TYR F 25 
AA1 16 17 N ILE F 24 ? N ILE F 24 O LEU F 32 ? O LEU F 32 
AA1 17 18 N SER F 38 ? N SER F 38 O LEU F 45 ? O LEU F 45 
AA1 18 19 N ILE F 44 ? N ILE F 44 O VAL F 54 ? O VAL F 54 
AA1 19 20 O TYR F 55 ? O TYR F 55 N SER E 60 ? N SER E 60 
AA1 20 21 O VAL E 63 ? O VAL E 63 N SER E 23 ? N SER E 23 
AA1 21 22 N ILE E 24 ? N ILE E 24 O LEU E 32 ? O LEU E 32 
AA1 22 23 N SER E 38 ? N SER E 38 O LEU E 45 ? O LEU E 45 
AA1 23 24 N ILE E 44 ? N ILE E 44 O VAL E 54 ? O VAL E 54 
AA1 24 25 O TYR E 55 ? O TYR E 55 N SER C 60 ? N SER C 60 
AA1 25 26 O SER C 60 ? O SER C 60 N TYR C 25 ? N TYR C 25 
AA1 26 27 N ILE C 24 ? N ILE C 24 O LEU C 32 ? O LEU C 32 
AA1 27 28 N SER C 38 ? N SER C 38 O LEU C 45 ? O LEU C 45 
AA1 28 29 N ILE C 44 ? N ILE C 44 O VAL C 54 ? O VAL C 54 
AA1 29 30 O TYR C 55 ? O TYR C 55 N SER A 60 ? N SER A 60 
AA1 30 31 O VAL A 63 ? O VAL A 63 N SER A 23 ? N SER A 23 
# 
_pdbx_entry_details.entry_id                   9H45 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1  1 O Q HOH 124 ? ? O Q HOH 145 ? ? 1.55 
2  1 O A HOH 214 ? ? O B HOH 222 ? ? 1.85 
3  1 O D HOH 225 ? ? O D HOH 231 ? ? 1.90 
4  1 O D HOH 206 ? ? O D HOH 225 ? ? 1.97 
5  1 O E HOH 218 ? ? O E HOH 230 ? ? 2.02 
6  1 O F HOH 234 ? ? O F HOH 242 ? ? 2.05 
7  1 O E HOH 209 ? ? O E HOH 225 ? ? 2.10 
8  1 O D HOH 208 ? ? O D HOH 210 ? ? 2.10 
9  1 O F HOH 229 ? ? O F HOH 240 ? ? 2.15 
10 1 O F HOH 234 ? ? O F HOH 243 ? ? 2.19 
# 
_pdbx_validate_symm_contact.id                1 
_pdbx_validate_symm_contact.PDB_model_num     1 
_pdbx_validate_symm_contact.auth_atom_id_1    O 
_pdbx_validate_symm_contact.auth_asym_id_1    B 
_pdbx_validate_symm_contact.auth_comp_id_1    HOH 
_pdbx_validate_symm_contact.auth_seq_id_1     211 
_pdbx_validate_symm_contact.PDB_ins_code_1    ? 
_pdbx_validate_symm_contact.label_alt_id_1    ? 
_pdbx_validate_symm_contact.site_symmetry_1   1_555 
_pdbx_validate_symm_contact.auth_atom_id_2    O 
_pdbx_validate_symm_contact.auth_asym_id_2    E 
_pdbx_validate_symm_contact.auth_comp_id_2    HOH 
_pdbx_validate_symm_contact.auth_seq_id_2     229 
_pdbx_validate_symm_contact.PDB_ins_code_2    ? 
_pdbx_validate_symm_contact.label_alt_id_2    ? 
_pdbx_validate_symm_contact.site_symmetry_2   1_545 
_pdbx_validate_symm_contact.dist              1.96 
# 
loop_
_pdbx_validate_rmsd_angle.id 
_pdbx_validate_rmsd_angle.PDB_model_num 
_pdbx_validate_rmsd_angle.auth_atom_id_1 
_pdbx_validate_rmsd_angle.auth_asym_id_1 
_pdbx_validate_rmsd_angle.auth_comp_id_1 
_pdbx_validate_rmsd_angle.auth_seq_id_1 
_pdbx_validate_rmsd_angle.PDB_ins_code_1 
_pdbx_validate_rmsd_angle.label_alt_id_1 
_pdbx_validate_rmsd_angle.auth_atom_id_2 
_pdbx_validate_rmsd_angle.auth_asym_id_2 
_pdbx_validate_rmsd_angle.auth_comp_id_2 
_pdbx_validate_rmsd_angle.auth_seq_id_2 
_pdbx_validate_rmsd_angle.PDB_ins_code_2 
_pdbx_validate_rmsd_angle.label_alt_id_2 
_pdbx_validate_rmsd_angle.auth_atom_id_3 
_pdbx_validate_rmsd_angle.auth_asym_id_3 
_pdbx_validate_rmsd_angle.auth_comp_id_3 
_pdbx_validate_rmsd_angle.auth_seq_id_3 
_pdbx_validate_rmsd_angle.PDB_ins_code_3 
_pdbx_validate_rmsd_angle.label_alt_id_3 
_pdbx_validate_rmsd_angle.angle_value 
_pdbx_validate_rmsd_angle.angle_target_value 
_pdbx_validate_rmsd_angle.angle_deviation 
_pdbx_validate_rmsd_angle.angle_standard_deviation 
_pdbx_validate_rmsd_angle.linker_flag 
1 1 "C3'" Q A 4  ? ? "O3'" Q A 4  ? ? P   Q A 5  ? ? 110.55 119.70 -9.15  1.20 Y 
2 1 "C3'" Q A 10 ? ? "O3'" Q A 10 ? ? P   Q A 11 ? ? 112.45 119.70 -7.25  1.20 Y 
3 1 "C3'" Q A 13 ? ? "O3'" Q A 13 ? ? P   Q A 14 ? ? 111.98 119.70 -7.72  1.20 Y 
4 1 "O3'" Q A 17 ? ? P     Q A 18 ? ? OP1 Q A 18 ? ? 119.43 110.50 8.93   1.10 Y 
5 1 OP1   Q A 18 ? ? P     Q A 18 ? ? OP2 Q A 18 ? ? 108.72 119.60 -10.88 1.50 N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 ASP A 40 ? ? -137.88 -159.97 
2  1 ASN A 48 ? ? -155.51 -110.85 
3  1 ASN B 48 ? ? -159.08 -85.29  
4  1 ASN C 48 ? ? -167.60 -108.51 
5  1 ASN D 48 ? ? -152.79 -66.07  
6  1 LEU E 7  ? ? -137.46 -36.40  
7  1 ASN E 48 ? ? -153.12 -114.86 
8  1 SER F 38 ? ? 179.06  166.65  
9  1 ASP F 40 ? ? -135.03 -159.59 
10 1 ASN F 48 ? ? -132.13 -106.26 
# 
loop_
_pdbx_validate_planes.id 
_pdbx_validate_planes.PDB_model_num 
_pdbx_validate_planes.auth_comp_id 
_pdbx_validate_planes.auth_asym_id 
_pdbx_validate_planes.auth_seq_id 
_pdbx_validate_planes.PDB_ins_code 
_pdbx_validate_planes.label_alt_id 
_pdbx_validate_planes.rmsd 
_pdbx_validate_planes.type 
1 1 ARG D 19 ? ? 0.130 'SIDE CHAIN' 
2 1 ARG E 16 ? ? 0.229 'SIDE CHAIN' 
3 1 ARG E 66 ? ? 0.210 'SIDE CHAIN' 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? D HOH 238 ? 6.05 . 
2 1 O ? E HOH 239 ? 6.80 . 
3 1 O ? E HOH 240 ? 7.24 . 
4 1 O ? E HOH 241 ? 7.85 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A MET 1   ? A MET 1   
2   1 Y 1 A ALA 2   ? A ALA 2   
3   1 Y 1 A LYS 3   ? A LYS 3   
4   1 Y 1 A GLY 4   ? A GLY 4   
5   1 Y 1 A HIS 70  ? A HIS 70  
6   1 Y 1 A HIS 71  ? A HIS 71  
7   1 Y 1 A SER 72  ? A SER 72  
8   1 Y 1 A ASN 73  ? A ASN 73  
9   1 Y 1 A ASN 74  ? A ASN 74  
10  1 Y 1 A ALA 75  ? A ALA 75  
11  1 Y 1 A GLY 76  ? A GLY 76  
12  1 Y 1 A GLY 77  ? A GLY 77  
13  1 Y 1 A GLY 78  ? A GLY 78  
14  1 Y 1 A THR 79  ? A THR 79  
15  1 Y 1 A SER 80  ? A SER 80  
16  1 Y 1 A SER 81  ? A SER 81  
17  1 Y 1 A ASN 82  ? A ASN 82  
18  1 Y 1 A TYR 83  ? A TYR 83  
19  1 Y 1 A HIS 84  ? A HIS 84  
20  1 Y 1 A HIS 85  ? A HIS 85  
21  1 Y 1 A GLY 86  ? A GLY 86  
22  1 Y 1 A SER 87  ? A SER 87  
23  1 Y 1 A SER 88  ? A SER 88  
24  1 Y 1 A ALA 89  ? A ALA 89  
25  1 Y 1 A GLN 90  ? A GLN 90  
26  1 Y 1 A ASN 91  ? A ASN 91  
27  1 Y 1 A THR 92  ? A THR 92  
28  1 Y 1 A SER 93  ? A SER 93  
29  1 Y 1 A ALA 94  ? A ALA 94  
30  1 Y 1 A GLN 95  ? A GLN 95  
31  1 Y 1 A GLN 96  ? A GLN 96  
32  1 Y 1 A ASP 97  ? A ASP 97  
33  1 Y 1 A SER 98  ? A SER 98  
34  1 Y 1 A GLU 99  ? A GLU 99  
35  1 Y 1 A GLU 100 ? A GLU 100 
36  1 Y 1 A THR 101 ? A THR 101 
37  1 Y 1 A GLU 102 ? A GLU 102 
38  1 Y 1 B MET 1   ? B MET 1   
39  1 Y 1 B ALA 2   ? B ALA 2   
40  1 Y 1 B LYS 3   ? B LYS 3   
41  1 Y 1 B GLY 4   ? B GLY 4   
42  1 Y 1 B GLN 5   ? B GLN 5   
43  1 Y 1 B SER 69  ? B SER 69  
44  1 Y 1 B HIS 70  ? B HIS 70  
45  1 Y 1 B HIS 71  ? B HIS 71  
46  1 Y 1 B SER 72  ? B SER 72  
47  1 Y 1 B ASN 73  ? B ASN 73  
48  1 Y 1 B ASN 74  ? B ASN 74  
49  1 Y 1 B ALA 75  ? B ALA 75  
50  1 Y 1 B GLY 76  ? B GLY 76  
51  1 Y 1 B GLY 77  ? B GLY 77  
52  1 Y 1 B GLY 78  ? B GLY 78  
53  1 Y 1 B THR 79  ? B THR 79  
54  1 Y 1 B SER 80  ? B SER 80  
55  1 Y 1 B SER 81  ? B SER 81  
56  1 Y 1 B ASN 82  ? B ASN 82  
57  1 Y 1 B TYR 83  ? B TYR 83  
58  1 Y 1 B HIS 84  ? B HIS 84  
59  1 Y 1 B HIS 85  ? B HIS 85  
60  1 Y 1 B GLY 86  ? B GLY 86  
61  1 Y 1 B SER 87  ? B SER 87  
62  1 Y 1 B SER 88  ? B SER 88  
63  1 Y 1 B ALA 89  ? B ALA 89  
64  1 Y 1 B GLN 90  ? B GLN 90  
65  1 Y 1 B ASN 91  ? B ASN 91  
66  1 Y 1 B THR 92  ? B THR 92  
67  1 Y 1 B SER 93  ? B SER 93  
68  1 Y 1 B ALA 94  ? B ALA 94  
69  1 Y 1 B GLN 95  ? B GLN 95  
70  1 Y 1 B GLN 96  ? B GLN 96  
71  1 Y 1 B ASP 97  ? B ASP 97  
72  1 Y 1 B SER 98  ? B SER 98  
73  1 Y 1 B GLU 99  ? B GLU 99  
74  1 Y 1 B GLU 100 ? B GLU 100 
75  1 Y 1 B THR 101 ? B THR 101 
76  1 Y 1 B GLU 102 ? B GLU 102 
77  1 Y 1 C MET 1   ? C MET 1   
78  1 Y 1 C ALA 2   ? C ALA 2   
79  1 Y 1 C LYS 3   ? C LYS 3   
80  1 Y 1 C GLY 4   ? C GLY 4   
81  1 Y 1 C GLN 5   ? C GLN 5   
82  1 Y 1 C SER 69  ? C SER 69  
83  1 Y 1 C HIS 70  ? C HIS 70  
84  1 Y 1 C HIS 71  ? C HIS 71  
85  1 Y 1 C SER 72  ? C SER 72  
86  1 Y 1 C ASN 73  ? C ASN 73  
87  1 Y 1 C ASN 74  ? C ASN 74  
88  1 Y 1 C ALA 75  ? C ALA 75  
89  1 Y 1 C GLY 76  ? C GLY 76  
90  1 Y 1 C GLY 77  ? C GLY 77  
91  1 Y 1 C GLY 78  ? C GLY 78  
92  1 Y 1 C THR 79  ? C THR 79  
93  1 Y 1 C SER 80  ? C SER 80  
94  1 Y 1 C SER 81  ? C SER 81  
95  1 Y 1 C ASN 82  ? C ASN 82  
96  1 Y 1 C TYR 83  ? C TYR 83  
97  1 Y 1 C HIS 84  ? C HIS 84  
98  1 Y 1 C HIS 85  ? C HIS 85  
99  1 Y 1 C GLY 86  ? C GLY 86  
100 1 Y 1 C SER 87  ? C SER 87  
101 1 Y 1 C SER 88  ? C SER 88  
102 1 Y 1 C ALA 89  ? C ALA 89  
103 1 Y 1 C GLN 90  ? C GLN 90  
104 1 Y 1 C ASN 91  ? C ASN 91  
105 1 Y 1 C THR 92  ? C THR 92  
106 1 Y 1 C SER 93  ? C SER 93  
107 1 Y 1 C ALA 94  ? C ALA 94  
108 1 Y 1 C GLN 95  ? C GLN 95  
109 1 Y 1 C GLN 96  ? C GLN 96  
110 1 Y 1 C ASP 97  ? C ASP 97  
111 1 Y 1 C SER 98  ? C SER 98  
112 1 Y 1 C GLU 99  ? C GLU 99  
113 1 Y 1 C GLU 100 ? C GLU 100 
114 1 Y 1 C THR 101 ? C THR 101 
115 1 Y 1 C GLU 102 ? C GLU 102 
116 1 Y 1 D MET 1   ? D MET 1   
117 1 Y 1 D ALA 2   ? D ALA 2   
118 1 Y 1 D LYS 3   ? D LYS 3   
119 1 Y 1 D GLY 4   ? D GLY 4   
120 1 Y 1 D GLN 5   ? D GLN 5   
121 1 Y 1 D SER 6   ? D SER 6   
122 1 Y 1 D ALA 14  ? D ALA 14  
123 1 Y 1 D SER 69  ? D SER 69  
124 1 Y 1 D HIS 70  ? D HIS 70  
125 1 Y 1 D HIS 71  ? D HIS 71  
126 1 Y 1 D SER 72  ? D SER 72  
127 1 Y 1 D ASN 73  ? D ASN 73  
128 1 Y 1 D ASN 74  ? D ASN 74  
129 1 Y 1 D ALA 75  ? D ALA 75  
130 1 Y 1 D GLY 76  ? D GLY 76  
131 1 Y 1 D GLY 77  ? D GLY 77  
132 1 Y 1 D GLY 78  ? D GLY 78  
133 1 Y 1 D THR 79  ? D THR 79  
134 1 Y 1 D SER 80  ? D SER 80  
135 1 Y 1 D SER 81  ? D SER 81  
136 1 Y 1 D ASN 82  ? D ASN 82  
137 1 Y 1 D TYR 83  ? D TYR 83  
138 1 Y 1 D HIS 84  ? D HIS 84  
139 1 Y 1 D HIS 85  ? D HIS 85  
140 1 Y 1 D GLY 86  ? D GLY 86  
141 1 Y 1 D SER 87  ? D SER 87  
142 1 Y 1 D SER 88  ? D SER 88  
143 1 Y 1 D ALA 89  ? D ALA 89  
144 1 Y 1 D GLN 90  ? D GLN 90  
145 1 Y 1 D ASN 91  ? D ASN 91  
146 1 Y 1 D THR 92  ? D THR 92  
147 1 Y 1 D SER 93  ? D SER 93  
148 1 Y 1 D ALA 94  ? D ALA 94  
149 1 Y 1 D GLN 95  ? D GLN 95  
150 1 Y 1 D GLN 96  ? D GLN 96  
151 1 Y 1 D ASP 97  ? D ASP 97  
152 1 Y 1 D SER 98  ? D SER 98  
153 1 Y 1 D GLU 99  ? D GLU 99  
154 1 Y 1 D GLU 100 ? D GLU 100 
155 1 Y 1 D THR 101 ? D THR 101 
156 1 Y 1 D GLU 102 ? D GLU 102 
157 1 Y 1 E MET 1   ? E MET 1   
158 1 Y 1 E ALA 2   ? E ALA 2   
159 1 Y 1 E LYS 3   ? E LYS 3   
160 1 Y 1 E GLY 4   ? E GLY 4   
161 1 Y 1 E GLN 5   ? E GLN 5   
162 1 Y 1 E SER 69  ? E SER 69  
163 1 Y 1 E HIS 70  ? E HIS 70  
164 1 Y 1 E HIS 71  ? E HIS 71  
165 1 Y 1 E SER 72  ? E SER 72  
166 1 Y 1 E ASN 73  ? E ASN 73  
167 1 Y 1 E ASN 74  ? E ASN 74  
168 1 Y 1 E ALA 75  ? E ALA 75  
169 1 Y 1 E GLY 76  ? E GLY 76  
170 1 Y 1 E GLY 77  ? E GLY 77  
171 1 Y 1 E GLY 78  ? E GLY 78  
172 1 Y 1 E THR 79  ? E THR 79  
173 1 Y 1 E SER 80  ? E SER 80  
174 1 Y 1 E SER 81  ? E SER 81  
175 1 Y 1 E ASN 82  ? E ASN 82  
176 1 Y 1 E TYR 83  ? E TYR 83  
177 1 Y 1 E HIS 84  ? E HIS 84  
178 1 Y 1 E HIS 85  ? E HIS 85  
179 1 Y 1 E GLY 86  ? E GLY 86  
180 1 Y 1 E SER 87  ? E SER 87  
181 1 Y 1 E SER 88  ? E SER 88  
182 1 Y 1 E ALA 89  ? E ALA 89  
183 1 Y 1 E GLN 90  ? E GLN 90  
184 1 Y 1 E ASN 91  ? E ASN 91  
185 1 Y 1 E THR 92  ? E THR 92  
186 1 Y 1 E SER 93  ? E SER 93  
187 1 Y 1 E ALA 94  ? E ALA 94  
188 1 Y 1 E GLN 95  ? E GLN 95  
189 1 Y 1 E GLN 96  ? E GLN 96  
190 1 Y 1 E ASP 97  ? E ASP 97  
191 1 Y 1 E SER 98  ? E SER 98  
192 1 Y 1 E GLU 99  ? E GLU 99  
193 1 Y 1 E GLU 100 ? E GLU 100 
194 1 Y 1 E THR 101 ? E THR 101 
195 1 Y 1 E GLU 102 ? E GLU 102 
196 1 Y 1 F MET 1   ? F MET 1   
197 1 Y 1 F ALA 2   ? F ALA 2   
198 1 Y 1 F LYS 3   ? F LYS 3   
199 1 Y 1 F GLY 4   ? F GLY 4   
200 1 Y 1 F SER 69  ? F SER 69  
201 1 Y 1 F HIS 70  ? F HIS 70  
202 1 Y 1 F HIS 71  ? F HIS 71  
203 1 Y 1 F SER 72  ? F SER 72  
204 1 Y 1 F ASN 73  ? F ASN 73  
205 1 Y 1 F ASN 74  ? F ASN 74  
206 1 Y 1 F ALA 75  ? F ALA 75  
207 1 Y 1 F GLY 76  ? F GLY 76  
208 1 Y 1 F GLY 77  ? F GLY 77  
209 1 Y 1 F GLY 78  ? F GLY 78  
210 1 Y 1 F THR 79  ? F THR 79  
211 1 Y 1 F SER 80  ? F SER 80  
212 1 Y 1 F SER 81  ? F SER 81  
213 1 Y 1 F ASN 82  ? F ASN 82  
214 1 Y 1 F TYR 83  ? F TYR 83  
215 1 Y 1 F HIS 84  ? F HIS 84  
216 1 Y 1 F HIS 85  ? F HIS 85  
217 1 Y 1 F GLY 86  ? F GLY 86  
218 1 Y 1 F SER 87  ? F SER 87  
219 1 Y 1 F SER 88  ? F SER 88  
220 1 Y 1 F ALA 89  ? F ALA 89  
221 1 Y 1 F GLN 90  ? F GLN 90  
222 1 Y 1 F ASN 91  ? F ASN 91  
223 1 Y 1 F THR 92  ? F THR 92  
224 1 Y 1 F SER 93  ? F SER 93  
225 1 Y 1 F ALA 94  ? F ALA 94  
226 1 Y 1 F GLN 95  ? F GLN 95  
227 1 Y 1 F GLN 96  ? F GLN 96  
228 1 Y 1 F ASP 97  ? F ASP 97  
229 1 Y 1 F SER 98  ? F SER 98  
230 1 Y 1 F GLU 99  ? F GLU 99  
231 1 Y 1 F GLU 100 ? F GLU 100 
232 1 Y 1 F THR 101 ? F THR 101 
233 1 Y 1 F GLU 102 ? F GLU 102 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A   OP3    O N N 1   
A   P      P N N 2   
A   OP1    O N N 3   
A   OP2    O N N 4   
A   "O5'"  O N N 5   
A   "C5'"  C N N 6   
A   "C4'"  C N R 7   
A   "O4'"  O N N 8   
A   "C3'"  C N S 9   
A   "O3'"  O N N 10  
A   "C2'"  C N R 11  
A   "O2'"  O N N 12  
A   "C1'"  C N R 13  
A   N9     N Y N 14  
A   C8     C Y N 15  
A   N7     N Y N 16  
A   C5     C Y N 17  
A   C6     C Y N 18  
A   N6     N N N 19  
A   N1     N Y N 20  
A   C2     C Y N 21  
A   N3     N Y N 22  
A   C4     C Y N 23  
A   HOP3   H N N 24  
A   HOP2   H N N 25  
A   "H5'"  H N N 26  
A   "H5''" H N N 27  
A   "H4'"  H N N 28  
A   "H3'"  H N N 29  
A   "HO3'" H N N 30  
A   "H2'"  H N N 31  
A   "HO2'" H N N 32  
A   "H1'"  H N N 33  
A   H8     H N N 34  
A   H61    H N N 35  
A   H62    H N N 36  
A   H2     H N N 37  
ALA N      N N N 38  
ALA CA     C N S 39  
ALA C      C N N 40  
ALA O      O N N 41  
ALA CB     C N N 42  
ALA OXT    O N N 43  
ALA H      H N N 44  
ALA H2     H N N 45  
ALA HA     H N N 46  
ALA HB1    H N N 47  
ALA HB2    H N N 48  
ALA HB3    H N N 49  
ALA HXT    H N N 50  
ARG N      N N N 51  
ARG CA     C N S 52  
ARG C      C N N 53  
ARG O      O N N 54  
ARG CB     C N N 55  
ARG CG     C N N 56  
ARG CD     C N N 57  
ARG NE     N N N 58  
ARG CZ     C N N 59  
ARG NH1    N N N 60  
ARG NH2    N N N 61  
ARG OXT    O N N 62  
ARG H      H N N 63  
ARG H2     H N N 64  
ARG HA     H N N 65  
ARG HB2    H N N 66  
ARG HB3    H N N 67  
ARG HG2    H N N 68  
ARG HG3    H N N 69  
ARG HD2    H N N 70  
ARG HD3    H N N 71  
ARG HE     H N N 72  
ARG HH11   H N N 73  
ARG HH12   H N N 74  
ARG HH21   H N N 75  
ARG HH22   H N N 76  
ARG HXT    H N N 77  
ASN N      N N N 78  
ASN CA     C N S 79  
ASN C      C N N 80  
ASN O      O N N 81  
ASN CB     C N N 82  
ASN CG     C N N 83  
ASN OD1    O N N 84  
ASN ND2    N N N 85  
ASN OXT    O N N 86  
ASN H      H N N 87  
ASN H2     H N N 88  
ASN HA     H N N 89  
ASN HB2    H N N 90  
ASN HB3    H N N 91  
ASN HD21   H N N 92  
ASN HD22   H N N 93  
ASN HXT    H N N 94  
ASP N      N N N 95  
ASP CA     C N S 96  
ASP C      C N N 97  
ASP O      O N N 98  
ASP CB     C N N 99  
ASP CG     C N N 100 
ASP OD1    O N N 101 
ASP OD2    O N N 102 
ASP OXT    O N N 103 
ASP H      H N N 104 
ASP H2     H N N 105 
ASP HA     H N N 106 
ASP HB2    H N N 107 
ASP HB3    H N N 108 
ASP HD2    H N N 109 
ASP HXT    H N N 110 
GLN N      N N N 111 
GLN CA     C N S 112 
GLN C      C N N 113 
GLN O      O N N 114 
GLN CB     C N N 115 
GLN CG     C N N 116 
GLN CD     C N N 117 
GLN OE1    O N N 118 
GLN NE2    N N N 119 
GLN OXT    O N N 120 
GLN H      H N N 121 
GLN H2     H N N 122 
GLN HA     H N N 123 
GLN HB2    H N N 124 
GLN HB3    H N N 125 
GLN HG2    H N N 126 
GLN HG3    H N N 127 
GLN HE21   H N N 128 
GLN HE22   H N N 129 
GLN HXT    H N N 130 
GLU N      N N N 131 
GLU CA     C N S 132 
GLU C      C N N 133 
GLU O      O N N 134 
GLU CB     C N N 135 
GLU CG     C N N 136 
GLU CD     C N N 137 
GLU OE1    O N N 138 
GLU OE2    O N N 139 
GLU OXT    O N N 140 
GLU H      H N N 141 
GLU H2     H N N 142 
GLU HA     H N N 143 
GLU HB2    H N N 144 
GLU HB3    H N N 145 
GLU HG2    H N N 146 
GLU HG3    H N N 147 
GLU HE2    H N N 148 
GLU HXT    H N N 149 
GLY N      N N N 150 
GLY CA     C N N 151 
GLY C      C N N 152 
GLY O      O N N 153 
GLY OXT    O N N 154 
GLY H      H N N 155 
GLY H2     H N N 156 
GLY HA2    H N N 157 
GLY HA3    H N N 158 
GLY HXT    H N N 159 
HIS N      N N N 160 
HIS CA     C N S 161 
HIS C      C N N 162 
HIS O      O N N 163 
HIS CB     C N N 164 
HIS CG     C Y N 165 
HIS ND1    N Y N 166 
HIS CD2    C Y N 167 
HIS CE1    C Y N 168 
HIS NE2    N Y N 169 
HIS OXT    O N N 170 
HIS H      H N N 171 
HIS H2     H N N 172 
HIS HA     H N N 173 
HIS HB2    H N N 174 
HIS HB3    H N N 175 
HIS HD1    H N N 176 
HIS HD2    H N N 177 
HIS HE1    H N N 178 
HIS HE2    H N N 179 
HIS HXT    H N N 180 
HOH O      O N N 181 
HOH H1     H N N 182 
HOH H2     H N N 183 
ILE N      N N N 184 
ILE CA     C N S 185 
ILE C      C N N 186 
ILE O      O N N 187 
ILE CB     C N S 188 
ILE CG1    C N N 189 
ILE CG2    C N N 190 
ILE CD1    C N N 191 
ILE OXT    O N N 192 
ILE H      H N N 193 
ILE H2     H N N 194 
ILE HA     H N N 195 
ILE HB     H N N 196 
ILE HG12   H N N 197 
ILE HG13   H N N 198 
ILE HG21   H N N 199 
ILE HG22   H N N 200 
ILE HG23   H N N 201 
ILE HD11   H N N 202 
ILE HD12   H N N 203 
ILE HD13   H N N 204 
ILE HXT    H N N 205 
LEU N      N N N 206 
LEU CA     C N S 207 
LEU C      C N N 208 
LEU O      O N N 209 
LEU CB     C N N 210 
LEU CG     C N N 211 
LEU CD1    C N N 212 
LEU CD2    C N N 213 
LEU OXT    O N N 214 
LEU H      H N N 215 
LEU H2     H N N 216 
LEU HA     H N N 217 
LEU HB2    H N N 218 
LEU HB3    H N N 219 
LEU HG     H N N 220 
LEU HD11   H N N 221 
LEU HD12   H N N 222 
LEU HD13   H N N 223 
LEU HD21   H N N 224 
LEU HD22   H N N 225 
LEU HD23   H N N 226 
LEU HXT    H N N 227 
LYS N      N N N 228 
LYS CA     C N S 229 
LYS C      C N N 230 
LYS O      O N N 231 
LYS CB     C N N 232 
LYS CG     C N N 233 
LYS CD     C N N 234 
LYS CE     C N N 235 
LYS NZ     N N N 236 
LYS OXT    O N N 237 
LYS H      H N N 238 
LYS H2     H N N 239 
LYS HA     H N N 240 
LYS HB2    H N N 241 
LYS HB3    H N N 242 
LYS HG2    H N N 243 
LYS HG3    H N N 244 
LYS HD2    H N N 245 
LYS HD3    H N N 246 
LYS HE2    H N N 247 
LYS HE3    H N N 248 
LYS HZ1    H N N 249 
LYS HZ2    H N N 250 
LYS HZ3    H N N 251 
LYS HXT    H N N 252 
MET N      N N N 253 
MET CA     C N S 254 
MET C      C N N 255 
MET O      O N N 256 
MET CB     C N N 257 
MET CG     C N N 258 
MET SD     S N N 259 
MET CE     C N N 260 
MET OXT    O N N 261 
MET H      H N N 262 
MET H2     H N N 263 
MET HA     H N N 264 
MET HB2    H N N 265 
MET HB3    H N N 266 
MET HG2    H N N 267 
MET HG3    H N N 268 
MET HE1    H N N 269 
MET HE2    H N N 270 
MET HE3    H N N 271 
MET HXT    H N N 272 
PHE N      N N N 273 
PHE CA     C N S 274 
PHE C      C N N 275 
PHE O      O N N 276 
PHE CB     C N N 277 
PHE CG     C Y N 278 
PHE CD1    C Y N 279 
PHE CD2    C Y N 280 
PHE CE1    C Y N 281 
PHE CE2    C Y N 282 
PHE CZ     C Y N 283 
PHE OXT    O N N 284 
PHE H      H N N 285 
PHE H2     H N N 286 
PHE HA     H N N 287 
PHE HB2    H N N 288 
PHE HB3    H N N 289 
PHE HD1    H N N 290 
PHE HD2    H N N 291 
PHE HE1    H N N 292 
PHE HE2    H N N 293 
PHE HZ     H N N 294 
PHE HXT    H N N 295 
PRO N      N N N 296 
PRO CA     C N S 297 
PRO C      C N N 298 
PRO O      O N N 299 
PRO CB     C N N 300 
PRO CG     C N N 301 
PRO CD     C N N 302 
PRO OXT    O N N 303 
PRO H      H N N 304 
PRO HA     H N N 305 
PRO HB2    H N N 306 
PRO HB3    H N N 307 
PRO HG2    H N N 308 
PRO HG3    H N N 309 
PRO HD2    H N N 310 
PRO HD3    H N N 311 
PRO HXT    H N N 312 
SER N      N N N 313 
SER CA     C N S 314 
SER C      C N N 315 
SER O      O N N 316 
SER CB     C N N 317 
SER OG     O N N 318 
SER OXT    O N N 319 
SER H      H N N 320 
SER H2     H N N 321 
SER HA     H N N 322 
SER HB2    H N N 323 
SER HB3    H N N 324 
SER HG     H N N 325 
SER HXT    H N N 326 
THR N      N N N 327 
THR CA     C N S 328 
THR C      C N N 329 
THR O      O N N 330 
THR CB     C N R 331 
THR OG1    O N N 332 
THR CG2    C N N 333 
THR OXT    O N N 334 
THR H      H N N 335 
THR H2     H N N 336 
THR HA     H N N 337 
THR HB     H N N 338 
THR HG1    H N N 339 
THR HG21   H N N 340 
THR HG22   H N N 341 
THR HG23   H N N 342 
THR HXT    H N N 343 
TYR N      N N N 344 
TYR CA     C N S 345 
TYR C      C N N 346 
TYR O      O N N 347 
TYR CB     C N N 348 
TYR CG     C Y N 349 
TYR CD1    C Y N 350 
TYR CD2    C Y N 351 
TYR CE1    C Y N 352 
TYR CE2    C Y N 353 
TYR CZ     C Y N 354 
TYR OH     O N N 355 
TYR OXT    O N N 356 
TYR H      H N N 357 
TYR H2     H N N 358 
TYR HA     H N N 359 
TYR HB2    H N N 360 
TYR HB3    H N N 361 
TYR HD1    H N N 362 
TYR HD2    H N N 363 
TYR HE1    H N N 364 
TYR HE2    H N N 365 
TYR HH     H N N 366 
TYR HXT    H N N 367 
VAL N      N N N 368 
VAL CA     C N S 369 
VAL C      C N N 370 
VAL O      O N N 371 
VAL CB     C N N 372 
VAL CG1    C N N 373 
VAL CG2    C N N 374 
VAL OXT    O N N 375 
VAL H      H N N 376 
VAL H2     H N N 377 
VAL HA     H N N 378 
VAL HB     H N N 379 
VAL HG11   H N N 380 
VAL HG12   H N N 381 
VAL HG13   H N N 382 
VAL HG21   H N N 383 
VAL HG22   H N N 384 
VAL HG23   H N N 385 
VAL HXT    H N N 386 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A   OP3   P      sing N N 1   
A   OP3   HOP3   sing N N 2   
A   P     OP1    doub N N 3   
A   P     OP2    sing N N 4   
A   P     "O5'"  sing N N 5   
A   OP2   HOP2   sing N N 6   
A   "O5'" "C5'"  sing N N 7   
A   "C5'" "C4'"  sing N N 8   
A   "C5'" "H5'"  sing N N 9   
A   "C5'" "H5''" sing N N 10  
A   "C4'" "O4'"  sing N N 11  
A   "C4'" "C3'"  sing N N 12  
A   "C4'" "H4'"  sing N N 13  
A   "O4'" "C1'"  sing N N 14  
A   "C3'" "O3'"  sing N N 15  
A   "C3'" "C2'"  sing N N 16  
A   "C3'" "H3'"  sing N N 17  
A   "O3'" "HO3'" sing N N 18  
A   "C2'" "O2'"  sing N N 19  
A   "C2'" "C1'"  sing N N 20  
A   "C2'" "H2'"  sing N N 21  
A   "O2'" "HO2'" sing N N 22  
A   "C1'" N9     sing N N 23  
A   "C1'" "H1'"  sing N N 24  
A   N9    C8     sing Y N 25  
A   N9    C4     sing Y N 26  
A   C8    N7     doub Y N 27  
A   C8    H8     sing N N 28  
A   N7    C5     sing Y N 29  
A   C5    C6     sing Y N 30  
A   C5    C4     doub Y N 31  
A   C6    N6     sing N N 32  
A   C6    N1     doub Y N 33  
A   N6    H61    sing N N 34  
A   N6    H62    sing N N 35  
A   N1    C2     sing Y N 36  
A   C2    N3     doub Y N 37  
A   C2    H2     sing N N 38  
A   N3    C4     sing Y N 39  
ALA N     CA     sing N N 40  
ALA N     H      sing N N 41  
ALA N     H2     sing N N 42  
ALA CA    C      sing N N 43  
ALA CA    CB     sing N N 44  
ALA CA    HA     sing N N 45  
ALA C     O      doub N N 46  
ALA C     OXT    sing N N 47  
ALA CB    HB1    sing N N 48  
ALA CB    HB2    sing N N 49  
ALA CB    HB3    sing N N 50  
ALA OXT   HXT    sing N N 51  
ARG N     CA     sing N N 52  
ARG N     H      sing N N 53  
ARG N     H2     sing N N 54  
ARG CA    C      sing N N 55  
ARG CA    CB     sing N N 56  
ARG CA    HA     sing N N 57  
ARG C     O      doub N N 58  
ARG C     OXT    sing N N 59  
ARG CB    CG     sing N N 60  
ARG CB    HB2    sing N N 61  
ARG CB    HB3    sing N N 62  
ARG CG    CD     sing N N 63  
ARG CG    HG2    sing N N 64  
ARG CG    HG3    sing N N 65  
ARG CD    NE     sing N N 66  
ARG CD    HD2    sing N N 67  
ARG CD    HD3    sing N N 68  
ARG NE    CZ     sing N N 69  
ARG NE    HE     sing N N 70  
ARG CZ    NH1    sing N N 71  
ARG CZ    NH2    doub N N 72  
ARG NH1   HH11   sing N N 73  
ARG NH1   HH12   sing N N 74  
ARG NH2   HH21   sing N N 75  
ARG NH2   HH22   sing N N 76  
ARG OXT   HXT    sing N N 77  
ASN N     CA     sing N N 78  
ASN N     H      sing N N 79  
ASN N     H2     sing N N 80  
ASN CA    C      sing N N 81  
ASN CA    CB     sing N N 82  
ASN CA    HA     sing N N 83  
ASN C     O      doub N N 84  
ASN C     OXT    sing N N 85  
ASN CB    CG     sing N N 86  
ASN CB    HB2    sing N N 87  
ASN CB    HB3    sing N N 88  
ASN CG    OD1    doub N N 89  
ASN CG    ND2    sing N N 90  
ASN ND2   HD21   sing N N 91  
ASN ND2   HD22   sing N N 92  
ASN OXT   HXT    sing N N 93  
ASP N     CA     sing N N 94  
ASP N     H      sing N N 95  
ASP N     H2     sing N N 96  
ASP CA    C      sing N N 97  
ASP CA    CB     sing N N 98  
ASP CA    HA     sing N N 99  
ASP C     O      doub N N 100 
ASP C     OXT    sing N N 101 
ASP CB    CG     sing N N 102 
ASP CB    HB2    sing N N 103 
ASP CB    HB3    sing N N 104 
ASP CG    OD1    doub N N 105 
ASP CG    OD2    sing N N 106 
ASP OD2   HD2    sing N N 107 
ASP OXT   HXT    sing N N 108 
GLN N     CA     sing N N 109 
GLN N     H      sing N N 110 
GLN N     H2     sing N N 111 
GLN CA    C      sing N N 112 
GLN CA    CB     sing N N 113 
GLN CA    HA     sing N N 114 
GLN C     O      doub N N 115 
GLN C     OXT    sing N N 116 
GLN CB    CG     sing N N 117 
GLN CB    HB2    sing N N 118 
GLN CB    HB3    sing N N 119 
GLN CG    CD     sing N N 120 
GLN CG    HG2    sing N N 121 
GLN CG    HG3    sing N N 122 
GLN CD    OE1    doub N N 123 
GLN CD    NE2    sing N N 124 
GLN NE2   HE21   sing N N 125 
GLN NE2   HE22   sing N N 126 
GLN OXT   HXT    sing N N 127 
GLU N     CA     sing N N 128 
GLU N     H      sing N N 129 
GLU N     H2     sing N N 130 
GLU CA    C      sing N N 131 
GLU CA    CB     sing N N 132 
GLU CA    HA     sing N N 133 
GLU C     O      doub N N 134 
GLU C     OXT    sing N N 135 
GLU CB    CG     sing N N 136 
GLU CB    HB2    sing N N 137 
GLU CB    HB3    sing N N 138 
GLU CG    CD     sing N N 139 
GLU CG    HG2    sing N N 140 
GLU CG    HG3    sing N N 141 
GLU CD    OE1    doub N N 142 
GLU CD    OE2    sing N N 143 
GLU OE2   HE2    sing N N 144 
GLU OXT   HXT    sing N N 145 
GLY N     CA     sing N N 146 
GLY N     H      sing N N 147 
GLY N     H2     sing N N 148 
GLY CA    C      sing N N 149 
GLY CA    HA2    sing N N 150 
GLY CA    HA3    sing N N 151 
GLY C     O      doub N N 152 
GLY C     OXT    sing N N 153 
GLY OXT   HXT    sing N N 154 
HIS N     CA     sing N N 155 
HIS N     H      sing N N 156 
HIS N     H2     sing N N 157 
HIS CA    C      sing N N 158 
HIS CA    CB     sing N N 159 
HIS CA    HA     sing N N 160 
HIS C     O      doub N N 161 
HIS C     OXT    sing N N 162 
HIS CB    CG     sing N N 163 
HIS CB    HB2    sing N N 164 
HIS CB    HB3    sing N N 165 
HIS CG    ND1    sing Y N 166 
HIS CG    CD2    doub Y N 167 
HIS ND1   CE1    doub Y N 168 
HIS ND1   HD1    sing N N 169 
HIS CD2   NE2    sing Y N 170 
HIS CD2   HD2    sing N N 171 
HIS CE1   NE2    sing Y N 172 
HIS CE1   HE1    sing N N 173 
HIS NE2   HE2    sing N N 174 
HIS OXT   HXT    sing N N 175 
HOH O     H1     sing N N 176 
HOH O     H2     sing N N 177 
ILE N     CA     sing N N 178 
ILE N     H      sing N N 179 
ILE N     H2     sing N N 180 
ILE CA    C      sing N N 181 
ILE CA    CB     sing N N 182 
ILE CA    HA     sing N N 183 
ILE C     O      doub N N 184 
ILE C     OXT    sing N N 185 
ILE CB    CG1    sing N N 186 
ILE CB    CG2    sing N N 187 
ILE CB    HB     sing N N 188 
ILE CG1   CD1    sing N N 189 
ILE CG1   HG12   sing N N 190 
ILE CG1   HG13   sing N N 191 
ILE CG2   HG21   sing N N 192 
ILE CG2   HG22   sing N N 193 
ILE CG2   HG23   sing N N 194 
ILE CD1   HD11   sing N N 195 
ILE CD1   HD12   sing N N 196 
ILE CD1   HD13   sing N N 197 
ILE OXT   HXT    sing N N 198 
LEU N     CA     sing N N 199 
LEU N     H      sing N N 200 
LEU N     H2     sing N N 201 
LEU CA    C      sing N N 202 
LEU CA    CB     sing N N 203 
LEU CA    HA     sing N N 204 
LEU C     O      doub N N 205 
LEU C     OXT    sing N N 206 
LEU CB    CG     sing N N 207 
LEU CB    HB2    sing N N 208 
LEU CB    HB3    sing N N 209 
LEU CG    CD1    sing N N 210 
LEU CG    CD2    sing N N 211 
LEU CG    HG     sing N N 212 
LEU CD1   HD11   sing N N 213 
LEU CD1   HD12   sing N N 214 
LEU CD1   HD13   sing N N 215 
LEU CD2   HD21   sing N N 216 
LEU CD2   HD22   sing N N 217 
LEU CD2   HD23   sing N N 218 
LEU OXT   HXT    sing N N 219 
LYS N     CA     sing N N 220 
LYS N     H      sing N N 221 
LYS N     H2     sing N N 222 
LYS CA    C      sing N N 223 
LYS CA    CB     sing N N 224 
LYS CA    HA     sing N N 225 
LYS C     O      doub N N 226 
LYS C     OXT    sing N N 227 
LYS CB    CG     sing N N 228 
LYS CB    HB2    sing N N 229 
LYS CB    HB3    sing N N 230 
LYS CG    CD     sing N N 231 
LYS CG    HG2    sing N N 232 
LYS CG    HG3    sing N N 233 
LYS CD    CE     sing N N 234 
LYS CD    HD2    sing N N 235 
LYS CD    HD3    sing N N 236 
LYS CE    NZ     sing N N 237 
LYS CE    HE2    sing N N 238 
LYS CE    HE3    sing N N 239 
LYS NZ    HZ1    sing N N 240 
LYS NZ    HZ2    sing N N 241 
LYS NZ    HZ3    sing N N 242 
LYS OXT   HXT    sing N N 243 
MET N     CA     sing N N 244 
MET N     H      sing N N 245 
MET N     H2     sing N N 246 
MET CA    C      sing N N 247 
MET CA    CB     sing N N 248 
MET CA    HA     sing N N 249 
MET C     O      doub N N 250 
MET C     OXT    sing N N 251 
MET CB    CG     sing N N 252 
MET CB    HB2    sing N N 253 
MET CB    HB3    sing N N 254 
MET CG    SD     sing N N 255 
MET CG    HG2    sing N N 256 
MET CG    HG3    sing N N 257 
MET SD    CE     sing N N 258 
MET CE    HE1    sing N N 259 
MET CE    HE2    sing N N 260 
MET CE    HE3    sing N N 261 
MET OXT   HXT    sing N N 262 
PHE N     CA     sing N N 263 
PHE N     H      sing N N 264 
PHE N     H2     sing N N 265 
PHE CA    C      sing N N 266 
PHE CA    CB     sing N N 267 
PHE CA    HA     sing N N 268 
PHE C     O      doub N N 269 
PHE C     OXT    sing N N 270 
PHE CB    CG     sing N N 271 
PHE CB    HB2    sing N N 272 
PHE CB    HB3    sing N N 273 
PHE CG    CD1    doub Y N 274 
PHE CG    CD2    sing Y N 275 
PHE CD1   CE1    sing Y N 276 
PHE CD1   HD1    sing N N 277 
PHE CD2   CE2    doub Y N 278 
PHE CD2   HD2    sing N N 279 
PHE CE1   CZ     doub Y N 280 
PHE CE1   HE1    sing N N 281 
PHE CE2   CZ     sing Y N 282 
PHE CE2   HE2    sing N N 283 
PHE CZ    HZ     sing N N 284 
PHE OXT   HXT    sing N N 285 
PRO N     CA     sing N N 286 
PRO N     CD     sing N N 287 
PRO N     H      sing N N 288 
PRO CA    C      sing N N 289 
PRO CA    CB     sing N N 290 
PRO CA    HA     sing N N 291 
PRO C     O      doub N N 292 
PRO C     OXT    sing N N 293 
PRO CB    CG     sing N N 294 
PRO CB    HB2    sing N N 295 
PRO CB    HB3    sing N N 296 
PRO CG    CD     sing N N 297 
PRO CG    HG2    sing N N 298 
PRO CG    HG3    sing N N 299 
PRO CD    HD2    sing N N 300 
PRO CD    HD3    sing N N 301 
PRO OXT   HXT    sing N N 302 
SER N     CA     sing N N 303 
SER N     H      sing N N 304 
SER N     H2     sing N N 305 
SER CA    C      sing N N 306 
SER CA    CB     sing N N 307 
SER CA    HA     sing N N 308 
SER C     O      doub N N 309 
SER C     OXT    sing N N 310 
SER CB    OG     sing N N 311 
SER CB    HB2    sing N N 312 
SER CB    HB3    sing N N 313 
SER OG    HG     sing N N 314 
SER OXT   HXT    sing N N 315 
THR N     CA     sing N N 316 
THR N     H      sing N N 317 
THR N     H2     sing N N 318 
THR CA    C      sing N N 319 
THR CA    CB     sing N N 320 
THR CA    HA     sing N N 321 
THR C     O      doub N N 322 
THR C     OXT    sing N N 323 
THR CB    OG1    sing N N 324 
THR CB    CG2    sing N N 325 
THR CB    HB     sing N N 326 
THR OG1   HG1    sing N N 327 
THR CG2   HG21   sing N N 328 
THR CG2   HG22   sing N N 329 
THR CG2   HG23   sing N N 330 
THR OXT   HXT    sing N N 331 
TYR N     CA     sing N N 332 
TYR N     H      sing N N 333 
TYR N     H2     sing N N 334 
TYR CA    C      sing N N 335 
TYR CA    CB     sing N N 336 
TYR CA    HA     sing N N 337 
TYR C     O      doub N N 338 
TYR C     OXT    sing N N 339 
TYR CB    CG     sing N N 340 
TYR CB    HB2    sing N N 341 
TYR CB    HB3    sing N N 342 
TYR CG    CD1    doub Y N 343 
TYR CG    CD2    sing Y N 344 
TYR CD1   CE1    sing Y N 345 
TYR CD1   HD1    sing N N 346 
TYR CD2   CE2    doub Y N 347 
TYR CD2   HD2    sing N N 348 
TYR CE1   CZ     doub Y N 349 
TYR CE1   HE1    sing N N 350 
TYR CE2   CZ     sing Y N 351 
TYR CE2   HE2    sing N N 352 
TYR CZ    OH     sing N N 353 
TYR OH    HH     sing N N 354 
TYR OXT   HXT    sing N N 355 
VAL N     CA     sing N N 356 
VAL N     H      sing N N 357 
VAL N     H2     sing N N 358 
VAL CA    C      sing N N 359 
VAL CA    CB     sing N N 360 
VAL CA    HA     sing N N 361 
VAL C     O      doub N N 362 
VAL C     OXT    sing N N 363 
VAL CB    CG1    sing N N 364 
VAL CB    CG2    sing N N 365 
VAL CB    HB     sing N N 366 
VAL CG1   HG11   sing N N 367 
VAL CG1   HG12   sing N N 368 
VAL CG1   HG13   sing N N 369 
VAL CG2   HG21   sing N N 370 
VAL CG2   HG22   sing N N 371 
VAL CG2   HG23   sing N N 372 
VAL OXT   HXT    sing N N 373 
# 
_pdbx_audit_support.funding_organization   'Other government' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'in silico model' 
_pdbx_initial_refinement_model.source_name      AlphaFold 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9H45 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.008602 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.002247 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.014892 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.012220 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
P 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N     . GLN A 1 5  ? 7.848   13.356  4.437  1.00 51.99 ? 5   GLN A N     1 
ATOM   2    C CA    . GLN A 1 5  ? 7.170   12.070  4.520  1.00 69.54 ? 5   GLN A CA    1 
ATOM   3    C C     . GLN A 1 5  ? 7.122   11.603  5.975  1.00 83.92 ? 5   GLN A C     1 
ATOM   4    O O     . GLN A 1 5  ? 7.290   12.399  6.898  1.00 73.82 ? 5   GLN A O     1 
ATOM   5    C CB    . GLN A 1 5  ? 7.867   11.034  3.635  1.00 77.22 ? 5   GLN A CB    1 
ATOM   6    C CG    . GLN A 1 5  ? 6.965   9.879   3.224  1.00 72.34 ? 5   GLN A CG    1 
ATOM   7    C CD    . GLN A 1 5  ? 7.586   8.521   3.500  1.00 79.38 ? 5   GLN A CD    1 
ATOM   8    O OE1   . GLN A 1 5  ? 8.809   8.381   3.563  1.00 73.69 ? 5   GLN A OE1   1 
ATOM   9    N NE2   . GLN A 1 5  ? 6.741   7.514   3.686  1.00 69.27 ? 5   GLN A NE2   1 
ATOM   10   N N     . SER A 1 6  ? 6.891   10.312  6.177  1.00 83.46 ? 6   SER A N     1 
ATOM   11   C CA    . SER A 1 6  ? 6.670   9.784   7.512  1.00 60.93 ? 6   SER A CA    1 
ATOM   12   C C     . SER A 1 6  ? 7.983   9.545   8.244  1.00 52.38 ? 6   SER A C     1 
ATOM   13   O O     . SER A 1 6  ? 9.031   9.309   7.637  1.00 51.03 ? 6   SER A O     1 
ATOM   14   C CB    . SER A 1 6  ? 5.882   8.477   7.444  1.00 62.75 ? 6   SER A CB    1 
ATOM   15   O OG    . SER A 1 6  ? 6.728   7.346   7.586  1.00 56.60 ? 6   SER A OG    1 
ATOM   16   N N     . LEU A 1 7  ? 7.909   9.625   9.572  1.00 47.08 ? 7   LEU A N     1 
ATOM   17   C CA    . LEU A 1 7  ? 9.032   9.329   10.442 1.00 29.13 ? 7   LEU A CA    1 
ATOM   18   C C     . LEU A 1 7  ? 8.674   8.355   11.554 1.00 38.55 ? 7   LEU A C     1 
ATOM   19   O O     . LEU A 1 7  ? 9.533   8.055   12.391 1.00 38.06 ? 7   LEU A O     1 
ATOM   20   C CB    . LEU A 1 7  ? 9.574   10.616  11.073 1.00 39.89 ? 7   LEU A CB    1 
ATOM   21   C CG    . LEU A 1 7  ? 8.548   11.384  11.901 1.00 45.88 ? 7   LEU A CG    1 
ATOM   22   C CD1   . LEU A 1 7  ? 8.815   11.147  13.355 1.00 48.21 ? 7   LEU A CD1   1 
ATOM   23   C CD2   . LEU A 1 7  ? 8.621   12.865  11.600 1.00 39.88 ? 7   LEU A CD2   1 
ATOM   24   N N     . GLN A 1 8  ? 7.433   7.867   11.595 1.00 39.34 ? 8   GLN A N     1 
ATOM   25   C CA    . GLN A 1 8  ? 7.037   6.912   12.623 1.00 32.67 ? 8   GLN A CA    1 
ATOM   26   C C     . GLN A 1 8  ? 7.657   5.544   12.378 1.00 24.57 ? 8   GLN A C     1 
ATOM   27   O O     . GLN A 1 8  ? 8.115   4.886   13.320 1.00 17.33 ? 8   GLN A O     1 
ATOM   28   C CB    . GLN A 1 8  ? 5.514   6.802   12.660 1.00 38.43 ? 8   GLN A CB    1 
ATOM   29   C CG    . GLN A 1 8  ? 4.927   6.714   14.046 1.00 33.74 ? 8   GLN A CG    1 
ATOM   30   C CD    . GLN A 1 8  ? 3.419   6.617   14.019 1.00 21.17 ? 8   GLN A CD    1 
ATOM   31   O OE1   . GLN A 1 8  ? 2.721   7.628   14.056 1.00 23.18 ? 8   GLN A OE1   1 
ATOM   32   N NE2   . GLN A 1 8  ? 2.907   5.397   13.926 1.00 6.39  ? 8   GLN A NE2   1 
ATOM   33   N N     . ASP A 1 9  ? 7.671   5.097   11.124 1.00 21.29 ? 9   ASP A N     1 
ATOM   34   C CA    . ASP A 1 9  ? 8.222   3.780   10.817 1.00 40.86 ? 9   ASP A CA    1 
ATOM   35   C C     . ASP A 1 9  ? 9.684   3.661   11.215 1.00 36.65 ? 9   ASP A C     1 
ATOM   36   O O     . ASP A 1 9  ? 10.043  2.671   11.878 1.00 40.88 ? 9   ASP A O     1 
ATOM   37   C CB    . ASP A 1 9  ? 8.027   3.481   9.327  1.00 41.71 ? 9   ASP A CB    1 
ATOM   38   C CG    . ASP A 1 9  ? 6.565   3.455   8.928  1.00 36.06 ? 9   ASP A CG    1 
ATOM   39   O OD1   . ASP A 1 9  ? 5.708   3.287   9.821  1.00 42.33 ? 9   ASP A OD1   1 
ATOM   40   O OD2   . ASP A 1 9  ? 6.274   3.603   7.722  1.00 45.24 ? 9   ASP A OD2   1 
ATOM   41   N N     . PRO A 1 10 ? 10.570  4.597   10.864 1.00 29.69 ? 10  PRO A N     1 
ATOM   42   C CA    . PRO A 1 10 ? 11.976  4.449   11.286 1.00 30.18 ? 10  PRO A CA    1 
ATOM   43   C C     . PRO A 1 10 ? 12.150  4.462   12.796 1.00 24.04 ? 10  PRO A C     1 
ATOM   44   O O     . PRO A 1 10 ? 12.994  3.727   13.324 1.00 30.97 ? 10  PRO A O     1 
ATOM   45   C CB    . PRO A 1 10 ? 12.691  5.636   10.621 1.00 45.08 ? 10  PRO A CB    1 
ATOM   46   C CG    . PRO A 1 10 ? 11.705  6.300   9.737  1.00 54.93 ? 10  PRO A CG    1 
ATOM   47   C CD    . PRO A 1 10 ? 10.338  5.762   9.993  1.00 42.66 ? 10  PRO A CD    1 
ATOM   48   N N     . PHE A 1 11 ? 11.371  5.277   13.511 1.00 26.58 ? 11  PHE A N     1 
ATOM   49   C CA    . PHE A 1 11 ? 11.500  5.335   14.965 1.00 28.25 ? 11  PHE A CA    1 
ATOM   50   C C     . PHE A 1 11 ? 11.189  3.983   15.595 1.00 25.11 ? 11  PHE A C     1 
ATOM   51   O O     . PHE A 1 11 ? 11.940  3.492   16.446 1.00 28.00 ? 11  PHE A O     1 
ATOM   52   C CB    . PHE A 1 11 ? 10.579  6.418   15.532 1.00 23.39 ? 11  PHE A CB    1 
ATOM   53   C CG    . PHE A 1 11 ? 10.660  6.561   17.027 1.00 13.72 ? 11  PHE A CG    1 
ATOM   54   C CD1   . PHE A 1 11 ? 11.600  7.396   17.605 1.00 13.37 ? 11  PHE A CD1   1 
ATOM   55   C CD2   . PHE A 1 11 ? 9.793   5.865   17.852 1.00 15.49 ? 11  PHE A CD2   1 
ATOM   56   C CE1   . PHE A 1 11 ? 11.676  7.531   18.979 1.00 13.22 ? 11  PHE A CE1   1 
ATOM   57   C CE2   . PHE A 1 11 ? 9.865   5.996   19.226 1.00 11.73 ? 11  PHE A CE2   1 
ATOM   58   C CZ    . PHE A 1 11 ? 10.808  6.830   19.789 1.00 15.20 ? 11  PHE A CZ    1 
ATOM   59   N N     . LEU A 1 12 ? 10.077  3.367   15.191 1.00 30.29 ? 12  LEU A N     1 
ATOM   60   C CA    . LEU A 1 12 ? 9.743   2.044   15.706 1.00 25.98 ? 12  LEU A CA    1 
ATOM   61   C C     . LEU A 1 12 ? 10.695  0.988   15.157 1.00 29.81 ? 12  LEU A C     1 
ATOM   62   O O     . LEU A 1 12 ? 11.068  0.049   15.870 1.00 27.37 ? 12  LEU A O     1 
ATOM   63   C CB    . LEU A 1 12 ? 8.297   1.698   15.358 1.00 23.56 ? 12  LEU A CB    1 
ATOM   64   C CG    . LEU A 1 12 ? 7.217   2.588   15.978 1.00 10.55 ? 12  LEU A CG    1 
ATOM   65   C CD1   . LEU A 1 12 ? 5.835   2.122   15.542 1.00 23.65 ? 12  LEU A CD1   1 
ATOM   66   C CD2   . LEU A 1 12 ? 7.322   2.601   17.495 1.00 17.18 ? 12  LEU A CD2   1 
ATOM   67   N N     . ASN A 1 13 ? 11.103  1.128   13.893 1.00 24.74 ? 13  ASN A N     1 
ATOM   68   C CA    . ASN A 1 13 ? 12.047  0.179   13.315 1.00 45.91 ? 13  ASN A CA    1 
ATOM   69   C C     . ASN A 1 13 ? 13.398  0.239   14.015 1.00 39.16 ? 13  ASN A C     1 
ATOM   70   O O     . ASN A 1 13 ? 14.103  -0.774  14.087 1.00 46.80 ? 13  ASN A O     1 
ATOM   71   C CB    . ASN A 1 13 ? 12.214  0.446   11.819 1.00 31.92 ? 13  ASN A CB    1 
ATOM   72   C CG    . ASN A 1 13 ? 11.253  -0.365  10.970 1.00 33.95 ? 13  ASN A CG    1 
ATOM   73   O OD1   . ASN A 1 13 ? 11.011  -1.541  11.239 1.00 34.66 ? 13  ASN A OD1   1 
ATOM   74   N ND2   . ASN A 1 13 ? 10.702  0.262   9.937  1.00 40.19 ? 13  ASN A ND2   1 
ATOM   75   N N     . ALA A 1 14 ? 13.777  1.409   14.534 1.00 36.97 ? 14  ALA A N     1 
ATOM   76   C CA    . ALA A 1 14 ? 15.034  1.513   15.267 1.00 46.41 ? 14  ALA A CA    1 
ATOM   77   C C     . ALA A 1 14 ? 14.976  0.715   16.562 1.00 42.19 ? 14  ALA A C     1 
ATOM   78   O O     . ALA A 1 14 ? 15.973  0.110   16.974 1.00 46.84 ? 14  ALA A O     1 
ATOM   79   C CB    . ALA A 1 14 ? 15.352  2.979   15.557 1.00 35.11 ? 14  ALA A CB    1 
ATOM   80   N N     . LEU A 1 15 ? 13.816  0.701   17.215 1.00 39.30 ? 15  LEU A N     1 
ATOM   81   C CA    . LEU A 1 15 ? 13.666  -0.026  18.469 1.00 33.06 ? 15  LEU A CA    1 
ATOM   82   C C     . LEU A 1 15 ? 13.511  -1.521  18.221 1.00 42.26 ? 15  LEU A C     1 
ATOM   83   O O     . LEU A 1 15 ? 14.164  -2.341  18.877 1.00 30.01 ? 15  LEU A O     1 
ATOM   84   C CB    . LEU A 1 15 ? 12.464  0.524   19.235 1.00 39.58 ? 15  LEU A CB    1 
ATOM   85   C CG    . LEU A 1 15 ? 12.546  2.013   19.581 1.00 26.59 ? 15  LEU A CG    1 
ATOM   86   C CD1   . LEU A 1 15 ? 11.204  2.694   19.366 1.00 26.59 ? 15  LEU A CD1   1 
ATOM   87   C CD2   . LEU A 1 15 ? 13.015  2.208   21.011 1.00 24.25 ? 15  LEU A CD2   1 
ATOM   88   N N     . ARG A 1 16 ? 12.641  -1.889  17.277 1.00 37.19 ? 16  ARG A N     1 
ATOM   89   C CA    . ARG A 1 16 ? 12.476  -3.292  16.915 1.00 42.59 ? 16  ARG A CA    1 
ATOM   90   C C     . ARG A 1 16 ? 13.796  -3.905  16.465 1.00 34.23 ? 16  ARG A C     1 
ATOM   91   O O     . ARG A 1 16 ? 14.131  -5.029  16.854 1.00 34.79 ? 16  ARG A O     1 
ATOM   92   C CB    . ARG A 1 16 ? 11.422  -3.409  15.812 1.00 36.57 ? 16  ARG A CB    1 
ATOM   93   C CG    . ARG A 1 16 ? 11.035  -4.825  15.409 1.00 42.14 ? 16  ARG A CG    1 
ATOM   94   C CD    . ARG A 1 16 ? 10.364  -4.825  14.035 1.00 41.05 ? 16  ARG A CD    1 
ATOM   95   N NE    . ARG A 1 16 ? 11.226  -4.221  13.025 1.00 35.06 ? 16  ARG A NE    1 
ATOM   96   C CZ    . ARG A 1 16 ? 12.383  -4.733  12.629 1.00 57.32 ? 16  ARG A CZ    1 
ATOM   97   N NH1   . ARG A 1 16 ? 12.808  -5.906  13.073 1.00 42.63 ? 16  ARG A NH1   1 
ATOM   98   N NH2   . ARG A 1 16 ? 13.135  -4.053  11.769 1.00 50.36 ? 16  ARG A NH2   1 
ATOM   99   N N     . ARG A 1 17 ? 14.558  -3.180  15.645 1.00 43.66 ? 17  ARG A N     1 
ATOM   100  C CA    . ARG A 1 17 ? 15.826  -3.704  15.149 1.00 52.02 ? 17  ARG A CA    1 
ATOM   101  C C     . ARG A 1 17 ? 16.831  -3.877  16.281 1.00 44.24 ? 17  ARG A C     1 
ATOM   102  O O     . ARG A 1 17 ? 17.399  -4.960  16.461 1.00 47.53 ? 17  ARG A O     1 
ATOM   103  C CB    . ARG A 1 17 ? 16.379  -2.775  14.067 1.00 49.95 ? 17  ARG A CB    1 
ATOM   104  C CG    . ARG A 1 17 ? 17.824  -3.029  13.669 1.00 55.19 ? 17  ARG A CG    1 
ATOM   105  C CD    . ARG A 1 17 ? 18.389  -1.824  12.922 1.00 53.74 ? 17  ARG A CD    1 
ATOM   106  N NE    . ARG A 1 17 ? 18.658  -0.719  13.835 1.00 54.44 ? 17  ARG A NE    1 
ATOM   107  C CZ    . ARG A 1 17 ? 18.333  0.548   13.611 1.00 46.26 ? 17  ARG A CZ    1 
ATOM   108  N NH1   . ARG A 1 17 ? 17.745  0.925   12.487 1.00 36.71 ? 17  ARG A NH1   1 
ATOM   109  N NH2   . ARG A 1 17 ? 18.607  1.461   14.538 1.00 37.03 ? 17  ARG A NH2   1 
ATOM   110  N N     . GLU A 1 18 ? 17.071  -2.817  17.051 1.00 37.87 ? 18  GLU A N     1 
ATOM   111  C CA    . GLU A 1 18 ? 18.093  -2.839  18.090 1.00 27.86 ? 18  GLU A CA    1 
ATOM   112  C C     . GLU A 1 18 ? 17.649  -3.566  19.353 1.00 37.30 ? 18  GLU A C     1 
ATOM   113  O O     . GLU A 1 18 ? 18.435  -3.653  20.302 1.00 33.87 ? 18  GLU A O     1 
ATOM   114  C CB    . GLU A 1 18 ? 18.510  -1.410  18.441 1.00 38.32 ? 18  GLU A CB    1 
ATOM   115  C CG    . GLU A 1 18 ? 19.101  -0.636  17.273 1.00 49.04 ? 18  GLU A CG    1 
ATOM   116  C CD    . GLU A 1 18 ? 20.524  -1.051  16.956 1.00 52.66 ? 18  GLU A CD    1 
ATOM   117  O OE1   . GLU A 1 18 ? 21.120  -1.806  17.754 1.00 50.89 ? 18  GLU A OE1   1 
ATOM   118  O OE2   . GLU A 1 18 ? 21.049  -0.621  15.907 1.00 50.53 ? 18  GLU A OE2   1 
ATOM   119  N N     . ARG A 1 19 ? 16.420  -4.083  19.392 1.00 24.40 ? 19  ARG A N     1 
ATOM   120  C CA    . ARG A 1 19 ? 15.944  -4.895  20.511 1.00 15.65 ? 19  ARG A CA    1 
ATOM   121  C C     . ARG A 1 19 ? 16.011  -4.140  21.835 1.00 21.21 ? 19  ARG A C     1 
ATOM   122  O O     . ARG A 1 19 ? 16.257  -4.735  22.887 1.00 23.51 ? 19  ARG A O     1 
ATOM   123  C CB    . ARG A 1 19 ? 16.737  -6.201  20.618 1.00 30.31 ? 19  ARG A CB    1 
ATOM   124  C CG    . ARG A 1 19 ? 16.536  -7.158  19.456 1.00 31.50 ? 19  ARG A CG    1 
ATOM   125  C CD    . ARG A 1 19 ? 15.106  -7.679  19.406 1.00 28.23 ? 19  ARG A CD    1 
ATOM   126  N NE    . ARG A 1 19 ? 14.947  -8.785  18.466 1.00 32.67 ? 19  ARG A NE    1 
ATOM   127  C CZ    . ARG A 1 19 ? 15.171  -8.707  17.160 1.00 29.50 ? 19  ARG A CZ    1 
ATOM   128  N NH1   . ARG A 1 19 ? 15.587  -7.586  16.593 1.00 39.54 ? 19  ARG A NH1   1 
ATOM   129  N NH2   . ARG A 1 19 ? 14.982  -9.785  16.405 1.00 28.61 ? 19  ARG A NH2   1 
ATOM   130  N N     . VAL A 1 20 ? 15.790  -2.831  21.800 1.00 19.03 ? 20  VAL A N     1 
ATOM   131  C CA    . VAL A 1 20 ? 15.870  -2.007  23.004 1.00 22.08 ? 20  VAL A CA    1 
ATOM   132  C C     . VAL A 1 20 ? 14.522  -2.048  23.713 1.00 31.07 ? 20  VAL A C     1 
ATOM   133  O O     . VAL A 1 20 ? 13.479  -1.901  23.060 1.00 20.89 ? 20  VAL A O     1 
ATOM   134  C CB    . VAL A 1 20 ? 16.279  -0.562  22.670 1.00 43.17 ? 20  VAL A CB    1 
ATOM   135  C CG1   . VAL A 1 20 ? 15.464  -0.020  21.507 1.00 44.96 ? 20  VAL A CG1   1 
ATOM   136  C CG2   . VAL A 1 20 ? 16.123  0.341   23.892 1.00 31.35 ? 20  VAL A CG2   1 
ATOM   137  N N     . PRO A 1 21 ? 14.486  -2.243  25.034 1.00 24.96 ? 21  PRO A N     1 
ATOM   138  C CA    . PRO A 1 21 ? 13.199  -2.196  25.744 1.00 21.24 ? 21  PRO A CA    1 
ATOM   139  C C     . PRO A 1 21 ? 12.539  -0.835  25.585 1.00 21.66 ? 21  PRO A C     1 
ATOM   140  O O     . PRO A 1 21 ? 13.205  0.201   25.536 1.00 16.52 ? 21  PRO A O     1 
ATOM   141  C CB    . PRO A 1 21 ? 13.568  -2.471  27.207 1.00 32.80 ? 21  PRO A CB    1 
ATOM   142  C CG    . PRO A 1 21 ? 15.004  -2.824  27.239 1.00 30.10 ? 21  PRO A CG    1 
ATOM   143  C CD    . PRO A 1 21 ? 15.626  -2.569  25.911 1.00 22.00 ? 21  PRO A CD    1 
ATOM   144  N N     . ALA A 1 22 ? 11.207  -0.844  25.514 1.00 21.02 ? 22  ALA A N     1 
ATOM   145  C CA    . ALA A 1 22 ? 10.443  0.358   25.210 1.00 26.09 ? 22  ALA A CA    1 
ATOM   146  C C     . ALA A 1 22 ? 9.237   0.450   26.133 1.00 16.59 ? 22  ALA A C     1 
ATOM   147  O O     . ALA A 1 22 ? 8.681   -0.563  26.568 1.00 14.99 ? 22  ALA A O     1 
ATOM   148  C CB    . ALA A 1 22 ? 10.010  0.368   23.752 1.00 30.00 ? 22  ALA A CB    1 
ATOM   149  N N     . SER A 1 23 ? 8.840   1.685   26.430 1.00 14.88 ? 23  SER A N     1 
ATOM   150  C CA    . SER A 1 23 ? 7.655   1.977   27.223 1.00 15.27 ? 23  SER A CA    1 
ATOM   151  C C     . SER A 1 23 ? 6.624   2.664   26.338 1.00 23.96 ? 23  SER A C     1 
ATOM   152  O O     . SER A 1 23 ? 6.928   3.676   25.696 1.00 14.25 ? 23  SER A O     1 
ATOM   153  C CB    . SER A 1 23 ? 7.998   2.869   28.418 1.00 19.20 ? 23  SER A CB    1 
ATOM   154  O OG    . SER A 1 23 ? 8.499   2.108   29.502 1.00 18.42 ? 23  SER A OG    1 
ATOM   155  N N     . ILE A 1 24 ? 5.416   2.115   26.303 1.00 16.87 ? 24  ILE A N     1 
ATOM   156  C CA    . ILE A 1 24 ? 4.310   2.685   25.542 1.00 32.30 ? 24  ILE A CA    1 
ATOM   157  C C     . ILE A 1 24 ? 3.302   3.212   26.555 1.00 9.95  ? 24  ILE A C     1 
ATOM   158  O O     . ILE A 1 24 ? 2.557   2.438   27.168 1.00 13.16 ? 24  ILE A O     1 
ATOM   159  C CB    . ILE A 1 24 ? 3.671   1.663   24.595 1.00 22.80 ? 24  ILE A CB    1 
ATOM   160  C CG1   . ILE A 1 24 ? 4.580   1.412   23.390 1.00 17.59 ? 24  ILE A CG1   1 
ATOM   161  C CG2   . ILE A 1 24 ? 2.303   2.149   24.140 1.00 8.24  ? 24  ILE A CG2   1 
ATOM   162  C CD1   . ILE A 1 24 ? 4.219   0.175   22.594 1.00 10.90 ? 24  ILE A CD1   1 
ATOM   163  N N     . TYR A 1 25 ? 3.283   4.529   26.745 1.00 9.36  ? 25  TYR A N     1 
ATOM   164  C CA    . TYR A 1 25 ? 2.296   5.161   27.611 1.00 19.62 ? 25  TYR A CA    1 
ATOM   165  C C     . TYR A 1 25 ? 0.998   5.342   26.832 1.00 17.05 ? 25  TYR A C     1 
ATOM   166  O O     . TYR A 1 25 ? 0.992   5.949   25.755 1.00 16.52 ? 25  TYR A O     1 
ATOM   167  C CB    . TYR A 1 25 ? 2.804   6.506   28.124 1.00 15.47 ? 25  TYR A CB    1 
ATOM   168  C CG    . TYR A 1 25 ? 3.995   6.423   29.053 1.00 18.80 ? 25  TYR A CG    1 
ATOM   169  C CD1   . TYR A 1 25 ? 5.288   6.362   28.553 1.00 13.41 ? 25  TYR A CD1   1 
ATOM   170  C CD2   . TYR A 1 25 ? 3.826   6.416   30.431 1.00 19.27 ? 25  TYR A CD2   1 
ATOM   171  C CE1   . TYR A 1 25 ? 6.376   6.293   29.393 1.00 13.24 ? 25  TYR A CE1   1 
ATOM   172  C CE2   . TYR A 1 25 ? 4.911   6.350   31.280 1.00 13.48 ? 25  TYR A CE2   1 
ATOM   173  C CZ    . TYR A 1 25 ? 6.184   6.289   30.752 1.00 10.24 ? 25  TYR A CZ    1 
ATOM   174  O OH    . TYR A 1 25 ? 7.278   6.220   31.581 1.00 29.89 ? 25  TYR A OH    1 
ATOM   175  N N     . LEU A 1 26 ? -0.096  4.812   27.367 1.00 8.79  ? 26  LEU A N     1 
ATOM   176  C CA    . LEU A 1 26 ? -1.383  4.876   26.696 1.00 17.40 ? 26  LEU A CA    1 
ATOM   177  C C     . LEU A 1 26 ? -2.081  6.199   27.001 1.00 16.23 ? 26  LEU A C     1 
ATOM   178  O O     . LEU A 1 26 ? -1.684  6.958   27.888 1.00 10.36 ? 26  LEU A O     1 
ATOM   179  C CB    . LEU A 1 26 ? -2.261  3.697   27.114 1.00 14.37 ? 26  LEU A CB    1 
ATOM   180  C CG    . LEU A 1 26 ? -1.664  2.306   26.897 1.00 18.30 ? 26  LEU A CG    1 
ATOM   181  C CD1   . LEU A 1 26 ? -2.629  1.233   27.376 1.00 8.71  ? 26  LEU A CD1   1 
ATOM   182  C CD2   . LEU A 1 26 ? -1.306  2.097   25.434 1.00 14.14 ? 26  LEU A CD2   1 
ATOM   183  N N     . VAL A 1 27 ? -3.148  6.470   26.248 1.00 20.01 ? 27  VAL A N     1 
ATOM   184  C CA    . VAL A 1 27 ? -3.887  7.712   26.407 1.00 20.11 ? 27  VAL A CA    1 
ATOM   185  C C     . VAL A 1 27 ? -4.553  7.826   27.769 1.00 8.96  ? 27  VAL A C     1 
ATOM   186  O O     . VAL A 1 27 ? -5.027  8.908   28.126 1.00 6.06  ? 27  VAL A O     1 
ATOM   187  C CB    . VAL A 1 27 ? -4.945  7.854   25.291 1.00 9.02  ? 27  VAL A CB    1 
ATOM   188  C CG1   . VAL A 1 27 ? -4.272  7.970   23.935 1.00 12.08 ? 27  VAL A CG1   1 
ATOM   189  C CG2   . VAL A 1 27 ? -5.914  6.677   25.318 1.00 7.19  ? 27  VAL A CG2   1 
ATOM   190  N N     . ASN A 1 28 ? -4.607  6.737   28.536 1.00 22.45 ? 28  ASN A N     1 
ATOM   191  C CA    . ASN A 1 28 ? -5.188  6.751   29.873 1.00 5.74  ? 28  ASN A CA    1 
ATOM   192  C C     . ASN A 1 28 ? -4.131  6.675   30.968 1.00 13.11 ? 28  ASN A C     1 
ATOM   193  O O     . ASN A 1 28 ? -4.481  6.527   32.145 1.00 9.61  ? 28  ASN A O     1 
ATOM   194  C CB    . ASN A 1 28 ? -6.186  5.603   30.029 1.00 13.12 ? 28  ASN A CB    1 
ATOM   195  C CG    . ASN A 1 28 ? -5.517  4.242   30.046 1.00 10.25 ? 28  ASN A CG    1 
ATOM   196  O OD1   . ASN A 1 28 ? -4.331  4.114   29.747 1.00 11.85 ? 28  ASN A OD1   1 
ATOM   197  N ND2   . ASN A 1 28 ? -6.280  3.216   30.399 1.00 20.21 ? 28  ASN A ND2   1 
ATOM   198  N N     . GLY A 1 29 ? -2.850  6.763   30.612 1.00 15.12 ? 29  GLY A N     1 
ATOM   199  C CA    . GLY A 1 29 ? -1.770  6.789   31.569 1.00 9.28  ? 29  GLY A CA    1 
ATOM   200  C C     . GLY A 1 29 ? -1.057  5.467   31.758 1.00 16.89 ? 29  GLY A C     1 
ATOM   201  O O     . GLY A 1 29 ? 0.100   5.461   32.196 1.00 22.18 ? 29  GLY A O     1 
ATOM   202  N N     . ILE A 1 30 ? -1.711  4.349   31.437 1.00 19.38 ? 30  ILE A N     1 
ATOM   203  C CA    . ILE A 1 30 ? -1.103  3.046   31.667 1.00 29.90 ? 30  ILE A CA    1 
ATOM   204  C C     . ILE A 1 30 ? 0.148   2.911   30.813 1.00 5.85  ? 30  ILE A C     1 
ATOM   205  O O     . ILE A 1 30 ? 0.146   3.224   29.616 1.00 37.15 ? 30  ILE A O     1 
ATOM   206  C CB    . ILE A 1 30 ? -2.108  1.923   31.374 1.00 17.56 ? 30  ILE A CB    1 
ATOM   207  C CG1   . ILE A 1 30 ? -3.385  2.135   32.190 1.00 12.36 ? 30  ILE A CG1   1 
ATOM   208  C CG2   . ILE A 1 30 ? -1.491  0.563   31.678 1.00 9.87  ? 30  ILE A CG2   1 
ATOM   209  C CD1   . ILE A 1 30 ? -3.187  2.014   33.687 1.00 31.47 ? 30  ILE A CD1   1 
ATOM   210  N N     . LYS A 1 31 ? 1.225   2.438   31.429 1.00 4.04  ? 31  LYS A N     1 
ATOM   211  C CA    . LYS A 1 31 ? 2.518   2.302   30.772 1.00 19.15 ? 31  LYS A CA    1 
ATOM   212  C C     . LYS A 1 31 ? 2.743   0.836   30.422 1.00 16.05 ? 31  LYS A C     1 
ATOM   213  O O     . LYS A 1 31 ? 2.849   -0.009  31.317 1.00 4.77  ? 31  LYS A O     1 
ATOM   214  C CB    . LYS A 1 31 ? 3.626   2.838   31.682 1.00 18.21 ? 31  LYS A CB    1 
ATOM   215  C CG    . LYS A 1 31 ? 5.051   2.407   31.344 1.00 15.65 ? 31  LYS A CG    1 
ATOM   216  C CD    . LYS A 1 31 ? 5.873   2.225   32.622 1.00 23.86 ? 31  LYS A CD    1 
ATOM   217  C CE    . LYS A 1 31 ? 6.517   3.531   33.059 1.00 34.97 ? 31  LYS A CE    1 
ATOM   218  N NZ    . LYS A 1 31 ? 7.884   3.339   33.615 1.00 27.06 ? 31  LYS A NZ    1 
ATOM   219  N N     . LEU A 1 32 ? 2.827   0.541   29.125 1.00 19.63 ? 32  LEU A N     1 
ATOM   220  C CA    . LEU A 1 32 ? 3.132   -0.801  28.645 1.00 11.19 ? 32  LEU A CA    1 
ATOM   221  C C     . LEU A 1 32 ? 4.636   -0.928  28.427 1.00 26.18 ? 32  LEU A C     1 
ATOM   222  O O     . LEU A 1 32 ? 5.223   -0.163  27.654 1.00 15.12 ? 32  LEU A O     1 
ATOM   223  C CB    . LEU A 1 32 ? 2.385   -1.094  27.345 1.00 19.51 ? 32  LEU A CB    1 
ATOM   224  C CG    . LEU A 1 32 ? 0.860   -0.984  27.345 1.00 16.28 ? 32  LEU A CG    1 
ATOM   225  C CD1   . LEU A 1 32 ? 0.313   -1.494  26.015 1.00 10.45 ? 32  LEU A CD1   1 
ATOM   226  C CD2   . LEU A 1 32 ? 0.260   -1.746  28.505 1.00 6.67  ? 32  LEU A CD2   1 
ATOM   227  N N     . GLN A 1 33 ? 5.257   -1.889  29.105 1.00 28.27 ? 33  GLN A N     1 
ATOM   228  C CA    . GLN A 1 33 ? 6.685   -2.145  28.984 1.00 35.11 ? 33  GLN A CA    1 
ATOM   229  C C     . GLN A 1 33 ? 6.888   -3.434  28.204 1.00 20.74 ? 33  GLN A C     1 
ATOM   230  O O     . GLN A 1 33 ? 6.215   -4.435  28.473 1.00 23.54 ? 33  GLN A O     1 
ATOM   231  C CB    . GLN A 1 33 ? 7.348   -2.255  30.357 1.00 31.04 ? 33  GLN A CB    1 
ATOM   232  C CG    . GLN A 1 33 ? 8.030   -0.983  30.819 1.00 31.96 ? 33  GLN A CG    1 
ATOM   233  C CD    . GLN A 1 33 ? 8.576   -1.096  32.229 1.00 37.57 ? 33  GLN A CD    1 
ATOM   234  O OE1   . GLN A 1 33 ? 7.876   -0.818  33.201 1.00 15.25 ? 33  GLN A OE1   1 
ATOM   235  N NE2   . GLN A 1 33 ? 9.834   -1.508  32.346 1.00 43.64 ? 33  GLN A NE2   1 
ATOM   236  N N     . GLY A 1 34 ? 7.813   -3.408  27.251 1.00 24.92 ? 34  GLY A N     1 
ATOM   237  C CA    . GLY A 1 34 ? 8.092   -4.597  26.460 1.00 31.54 ? 34  GLY A CA    1 
ATOM   238  C C     . GLY A 1 34 ? 9.043   -4.297  25.321 1.00 25.18 ? 34  GLY A C     1 
ATOM   239  O O     . GLY A 1 34 ? 9.920   -3.433  25.433 1.00 22.63 ? 34  GLY A O     1 
ATOM   240  N N     . GLN A 1 35 ? 8.855   -5.026  24.223 1.00 18.36 ? 35  GLN A N     1 
ATOM   241  C CA    . GLN A 1 35 ? 9.697   -4.902  23.042 1.00 22.32 ? 35  GLN A CA    1 
ATOM   242  C C     . GLN A 1 35 ? 8.817   -4.769  21.811 1.00 12.92 ? 35  GLN A C     1 
ATOM   243  O O     . GLN A 1 35 ? 7.872   -5.545  21.635 1.00 29.03 ? 35  GLN A O     1 
ATOM   244  C CB    . GLN A 1 35 ? 10.623  -6.114  22.890 1.00 37.25 ? 35  GLN A CB    1 
ATOM   245  C CG    . GLN A 1 35 ? 11.758  -6.166  23.893 1.00 38.56 ? 35  GLN A CG    1 
ATOM   246  C CD    . GLN A 1 35 ? 13.121  -6.151  23.227 1.00 43.90 ? 35  GLN A CD    1 
ATOM   247  O OE1   . GLN A 1 35 ? 13.346  -5.423  22.260 1.00 38.95 ? 35  GLN A OE1   1 
ATOM   248  N NE2   . GLN A 1 35 ? 14.037  -6.964  23.740 1.00 48.26 ? 35  GLN A NE2   1 
ATOM   249  N N     . ILE A 1 36 ? 9.127   -3.792  20.964 1.00 11.05 ? 36  ILE A N     1 
ATOM   250  C CA    . ILE A 1 36 ? 8.421   -3.640  19.696 1.00 17.69 ? 36  ILE A CA    1 
ATOM   251  C C     . ILE A 1 36 ? 8.762   -4.845  18.825 1.00 26.20 ? 36  ILE A C     1 
ATOM   252  O O     . ILE A 1 36 ? 9.902   -4.996  18.378 1.00 34.11 ? 36  ILE A O     1 
ATOM   253  C CB    . ILE A 1 36 ? 8.789   -2.327  18.995 1.00 20.88 ? 36  ILE A CB    1 
ATOM   254  C CG1   . ILE A 1 36 ? 8.221   -1.131  19.761 1.00 33.42 ? 36  ILE A CG1   1 
ATOM   255  C CG2   . ILE A 1 36 ? 8.264   -2.327  17.566 1.00 28.18 ? 36  ILE A CG2   1 
ATOM   256  C CD1   . ILE A 1 36 ? 9.056   0.122   19.630 1.00 22.82 ? 36  ILE A CD1   1 
ATOM   257  N N     . GLU A 1 37 ? 7.776   -5.706  18.586 1.00 21.36 ? 37  GLU A N     1 
ATOM   258  C CA    . GLU A 1 37 ? 7.973   -6.884  17.752 1.00 10.80 ? 37  GLU A CA    1 
ATOM   259  C C     . GLU A 1 37 ? 7.580   -6.642  16.303 1.00 22.28 ? 37  GLU A C     1 
ATOM   260  O O     . GLU A 1 37 ? 8.197   -7.211  15.398 1.00 14.69 ? 37  GLU A O     1 
ATOM   261  C CB    . GLU A 1 37 ? 7.165   -8.056  18.315 1.00 26.01 ? 37  GLU A CB    1 
ATOM   262  C CG    . GLU A 1 37 ? 7.310   -9.358  17.551 1.00 41.42 ? 37  GLU A CG    1 
ATOM   263  C CD    . GLU A 1 37 ? 6.689   -10.526 18.293 1.00 55.11 ? 37  GLU A CD    1 
ATOM   264  O OE1   . GLU A 1 37 ? 6.100   -11.410 17.636 1.00 63.09 ? 37  GLU A OE1   1 
ATOM   265  O OE2   . GLU A 1 37 ? 6.785   -10.554 19.538 1.00 54.34 ? 37  GLU A OE2   1 
ATOM   266  N N     . SER A 1 38 ? 6.572   -5.812  16.065 1.00 31.59 ? 38  SER A N     1 
ATOM   267  C CA    . SER A 1 38 ? 6.124   -5.494  14.717 1.00 25.56 ? 38  SER A CA    1 
ATOM   268  C C     . SER A 1 38 ? 5.151   -4.330  14.829 1.00 16.02 ? 38  SER A C     1 
ATOM   269  O O     . SER A 1 38 ? 4.728   -3.956  15.926 1.00 11.87 ? 38  SER A O     1 
ATOM   270  C CB    . SER A 1 38 ? 5.470   -6.698  14.035 1.00 19.46 ? 38  SER A CB    1 
ATOM   271  O OG    . SER A 1 38 ? 4.714   -7.459  14.960 1.00 44.77 ? 38  SER A OG    1 
ATOM   272  N N     . PHE A 1 39 ? 4.806   -3.757  13.682 1.00 17.77 ? 39  PHE A N     1 
ATOM   273  C CA    . PHE A 1 39 ? 3.833   -2.676  13.651 1.00 21.72 ? 39  PHE A CA    1 
ATOM   274  C C     . PHE A 1 39 ? 3.328   -2.515  12.228 1.00 39.58 ? 39  PHE A C     1 
ATOM   275  O O     . PHE A 1 39 ? 3.989   -2.912  11.265 1.00 29.14 ? 39  PHE A O     1 
ATOM   276  C CB    . PHE A 1 39 ? 4.431   -1.361  14.165 1.00 21.85 ? 39  PHE A CB    1 
ATOM   277  C CG    . PHE A 1 39 ? 5.628   -0.892  13.390 1.00 24.20 ? 39  PHE A CG    1 
ATOM   278  C CD1   . PHE A 1 39 ? 6.900   -1.327  13.723 1.00 18.90 ? 39  PHE A CD1   1 
ATOM   279  C CD2   . PHE A 1 39 ? 5.482   -0.013  12.330 1.00 32.11 ? 39  PHE A CD2   1 
ATOM   280  C CE1   . PHE A 1 39 ? 8.004   -0.895  13.012 1.00 30.15 ? 39  PHE A CE1   1 
ATOM   281  C CE2   . PHE A 1 39 ? 6.582   0.422   11.614 1.00 32.12 ? 39  PHE A CE2   1 
ATOM   282  C CZ    . PHE A 1 39 ? 7.844   -0.020  11.956 1.00 27.49 ? 39  PHE A CZ    1 
ATOM   283  N N     . ASP A 1 40 ? 2.137   -1.938  12.113 1.00 27.65 ? 40  ASP A N     1 
ATOM   284  C CA    . ASP A 1 40 ? 1.543   -1.629  10.818 1.00 21.29 ? 40  ASP A CA    1 
ATOM   285  C C     . ASP A 1 40 ? 0.915   -0.243  10.925 1.00 28.80 ? 40  ASP A C     1 
ATOM   286  O O     . ASP A 1 40 ? 1.248   0.548   11.815 1.00 29.13 ? 40  ASP A O     1 
ATOM   287  C CB    . ASP A 1 40 ? 0.557   -2.732  10.393 1.00 30.22 ? 40  ASP A CB    1 
ATOM   288  C CG    . ASP A 1 40 ? -0.722  -2.747  11.221 1.00 29.66 ? 40  ASP A CG    1 
ATOM   289  O OD1   . ASP A 1 40 ? -0.926  -1.842  12.056 1.00 23.28 ? 40  ASP A OD1   1 
ATOM   290  O OD2   . ASP A 1 40 ? -1.531  -3.680  11.032 1.00 36.26 ? 40  ASP A OD2   1 
ATOM   291  N N     . GLN A 1 41 ? -0.017  0.061   10.020 1.00 32.37 ? 41  GLN A N     1 
ATOM   292  C CA    . GLN A 1 41 ? -0.603  1.396   9.997  1.00 28.75 ? 41  GLN A CA    1 
ATOM   293  C C     . GLN A 1 41 ? -1.323  1.726   11.297 1.00 32.16 ? 41  GLN A C     1 
ATOM   294  O O     . GLN A 1 41 ? -1.344  2.891   11.713 1.00 20.97 ? 41  GLN A O     1 
ATOM   295  C CB    . GLN A 1 41 ? -1.577  1.530   8.827  1.00 21.40 ? 41  GLN A CB    1 
ATOM   296  C CG    . GLN A 1 41 ? -2.096  2.949   8.626  1.00 41.23 ? 41  GLN A CG    1 
ATOM   297  C CD    . GLN A 1 41 ? -2.962  3.088   7.390  1.00 47.64 ? 41  GLN A CD    1 
ATOM   298  O OE1   . GLN A 1 41 ? -3.270  2.102   6.720  1.00 43.74 ? 41  GLN A OE1   1 
ATOM   299  N NE2   . GLN A 1 41 ? -3.366  4.317   7.084  1.00 36.64 ? 41  GLN A NE2   1 
ATOM   300  N N     . PHE A 1 42 ? -1.917  0.728   11.952 1.00 10.07 ? 42  PHE A N     1 
ATOM   301  C CA    . PHE A 1 42 ? -2.836  0.988   13.049 1.00 14.46 ? 42  PHE A CA    1 
ATOM   302  C C     . PHE A 1 42 ? -2.457  0.350   14.375 1.00 10.28 ? 42  PHE A C     1 
ATOM   303  O O     . PHE A 1 42 ? -3.008  0.757   15.403 1.00 7.09  ? 42  PHE A O     1 
ATOM   304  C CB    . PHE A 1 42 ? -4.249  0.512   12.678 1.00 24.49 ? 42  PHE A CB    1 
ATOM   305  C CG    . PHE A 1 42 ? -4.765  1.088   11.393 1.00 23.51 ? 42  PHE A CG    1 
ATOM   306  C CD1   . PHE A 1 42 ? -5.185  2.406   11.328 1.00 26.37 ? 42  PHE A CD1   1 
ATOM   307  C CD2   . PHE A 1 42 ? -4.829  0.313   10.248 1.00 27.28 ? 42  PHE A CD2   1 
ATOM   308  C CE1   . PHE A 1 42 ? -5.661  2.939   10.146 1.00 26.66 ? 42  PHE A CE1   1 
ATOM   309  C CE2   . PHE A 1 42 ? -5.303  0.839   9.064  1.00 23.54 ? 42  PHE A CE2   1 
ATOM   310  C CZ    . PHE A 1 42 ? -5.720  2.153   9.012  1.00 23.00 ? 42  PHE A CZ    1 
ATOM   311  N N     . VAL A 1 43 ? -1.549  -0.628  14.397 1.00 14.97 ? 43  VAL A N     1 
ATOM   312  C CA    . VAL A 1 43 ? -1.231  -1.335  15.630 1.00 10.29 ? 43  VAL A CA    1 
ATOM   313  C C     . VAL A 1 43 ? 0.267   -1.579  15.730 1.00 14.94 ? 43  VAL A C     1 
ATOM   314  O O     . VAL A 1 43 ? 1.002   -1.544  14.741 1.00 10.82 ? 43  VAL A O     1 
ATOM   315  C CB    . VAL A 1 43 ? -1.982  -2.684  15.741 1.00 21.00 ? 43  VAL A CB    1 
ATOM   316  C CG1   . VAL A 1 43 ? -3.458  -2.506  15.421 1.00 13.79 ? 43  VAL A CG1   1 
ATOM   317  C CG2   . VAL A 1 43 ? -1.346  -3.728  14.830 1.00 14.67 ? 43  VAL A CG2   1 
ATOM   318  N N     . ILE A 1 44 ? 0.709   -1.823  16.962 1.00 12.85 ? 44  ILE A N     1 
ATOM   319  C CA    . ILE A 1 44 ? 2.062   -2.265  17.264 1.00 24.44 ? 44  ILE A CA    1 
ATOM   320  C C     . ILE A 1 44 ? 1.957   -3.490  18.161 1.00 22.06 ? 44  ILE A C     1 
ATOM   321  O O     . ILE A 1 44 ? 1.135   -3.524  19.083 1.00 14.78 ? 44  ILE A O     1 
ATOM   322  C CB    . ILE A 1 44 ? 2.895   -1.166  17.957 1.00 14.25 ? 44  ILE A CB    1 
ATOM   323  C CG1   . ILE A 1 44 ? 2.943   0.104   17.107 1.00 17.21 ? 44  ILE A CG1   1 
ATOM   324  C CG2   . ILE A 1 44 ? 4.303   -1.675  18.236 1.00 19.05 ? 44  ILE A CG2   1 
ATOM   325  C CD1   . ILE A 1 44 ? 3.174   1.362   17.922 1.00 21.28 ? 44  ILE A CD1   1 
ATOM   326  N N     . LEU A 1 45 ? 2.786   -4.496  17.892 1.00 31.63 ? 45  LEU A N     1 
ATOM   327  C CA    . LEU A 1 45 ? 2.827   -5.705  18.710 1.00 13.21 ? 45  LEU A CA    1 
ATOM   328  C C     . LEU A 1 45 ? 3.916   -5.553  19.765 1.00 13.94 ? 45  LEU A C     1 
ATOM   329  O O     . LEU A 1 45 ? 5.104   -5.478  19.437 1.00 18.85 ? 45  LEU A O     1 
ATOM   330  C CB    . LEU A 1 45 ? 3.070   -6.938  17.844 1.00 22.05 ? 45  LEU A CB    1 
ATOM   331  C CG    . LEU A 1 45 ? 1.814   -7.619  17.302 1.00 28.18 ? 45  LEU A CG    1 
ATOM   332  C CD1   . LEU A 1 45 ? 1.484   -7.055  15.942 1.00 48.45 ? 45  LEU A CD1   1 
ATOM   333  C CD2   . LEU A 1 45 ? 1.993   -9.128  17.218 1.00 35.58 ? 45  LEU A CD2   1 
ATOM   334  N N     . LEU A 1 46 ? 3.508   -5.506  21.029 1.00 9.23  ? 46  LEU A N     1 
ATOM   335  C CA    . LEU A 1 46 ? 4.428   -5.443  22.155 1.00 19.98 ? 46  LEU A CA    1 
ATOM   336  C C     . LEU A 1 46 ? 4.615   -6.845  22.718 1.00 28.57 ? 46  LEU A C     1 
ATOM   337  O O     . LEU A 1 46 ? 3.639   -7.581  22.899 1.00 25.23 ? 46  LEU A O     1 
ATOM   338  C CB    . LEU A 1 46 ? 3.900   -4.502  23.236 1.00 15.22 ? 46  LEU A CB    1 
ATOM   339  C CG    . LEU A 1 46 ? 4.834   -4.217  24.412 1.00 25.79 ? 46  LEU A CG    1 
ATOM   340  C CD1   . LEU A 1 46 ? 6.045   -3.423  23.954 1.00 25.84 ? 46  LEU A CD1   1 
ATOM   341  C CD2   . LEU A 1 46 ? 4.085   -3.478  25.501 1.00 11.78 ? 46  LEU A CD2   1 
ATOM   342  N N     . LYS A 1 47 ? 5.863   -7.205  23.002 1.00 33.37 ? 47  LYS A N     1 
ATOM   343  C CA    . LYS A 1 47 ? 6.225   -8.555  23.408 1.00 29.85 ? 47  LYS A CA    1 
ATOM   344  C C     . LYS A 1 47 ? 6.790   -8.538  24.820 1.00 27.44 ? 47  LYS A C     1 
ATOM   345  O O     . LYS A 1 47 ? 7.619   -7.685  25.156 1.00 28.30 ? 47  LYS A O     1 
ATOM   346  C CB    . LYS A 1 47 ? 7.248   -9.154  22.435 1.00 21.45 ? 47  LYS A CB    1 
ATOM   347  C CG    . LYS A 1 47 ? 7.544   -10.644 22.617 1.00 45.27 ? 47  LYS A CG    1 
ATOM   348  C CD    . LYS A 1 47 ? 6.323   -11.450 23.034 1.00 43.64 ? 47  LYS A CD    1 
ATOM   349  C CE    . LYS A 1 47 ? 6.454   -12.907 22.618 1.00 46.23 ? 47  LYS A CE    1 
ATOM   350  N NZ    . LYS A 1 47 ? 7.854   -13.404 22.725 1.00 28.92 ? 47  LYS A NZ    1 
ATOM   351  N N     . ASN A 1 48 ? 6.337   -9.486  25.638 1.00 27.55 ? 48  ASN A N     1 
ATOM   352  C CA    . ASN A 1 48 ? 6.889   -9.718  26.967 1.00 36.07 ? 48  ASN A CA    1 
ATOM   353  C C     . ASN A 1 48 ? 6.603   -11.168 27.352 1.00 34.72 ? 48  ASN A C     1 
ATOM   354  O O     . ASN A 1 48 ? 7.176   -12.086 26.757 1.00 33.75 ? 48  ASN A O     1 
ATOM   355  C CB    . ASN A 1 48 ? 6.311   -8.709  27.955 1.00 34.16 ? 48  ASN A CB    1 
ATOM   356  C CG    . ASN A 1 48 ? 7.299   -8.322  29.036 1.00 47.42 ? 48  ASN A CG    1 
ATOM   357  O OD1   . ASN A 1 48 ? 8.158   -9.115  29.425 1.00 45.37 ? 48  ASN A OD1   1 
ATOM   358  N ND2   . ASN A 1 48 ? 7.198   -7.088  29.510 1.00 23.67 ? 48  ASN A ND2   1 
ATOM   359  N N     . THR A 1 49 ? 5.722   -11.396 28.329 1.00 49.51 ? 49  THR A N     1 
ATOM   360  C CA    . THR A 1 49 ? 5.282   -12.759 28.611 1.00 58.39 ? 49  THR A CA    1 
ATOM   361  C C     . THR A 1 49 ? 4.492   -13.327 27.435 1.00 35.91 ? 49  THR A C     1 
ATOM   362  O O     . THR A 1 49 ? 4.598   -14.518 27.118 1.00 37.87 ? 49  THR A O     1 
ATOM   363  C CB    . THR A 1 49 ? 4.441   -12.787 29.888 1.00 41.50 ? 49  THR A CB    1 
ATOM   364  O OG1   . THR A 1 49 ? 4.059   -14.136 30.182 1.00 44.30 ? 49  THR A OG1   1 
ATOM   365  C CG2   . THR A 1 49 ? 3.186   -11.932 29.733 1.00 55.84 ? 49  THR A CG2   1 
ATOM   366  N N     . VAL A 1 50 ? 3.690   -12.486 26.781 1.00 42.40 ? 50  VAL A N     1 
ATOM   367  C CA    . VAL A 1 50 ? 2.989   -12.835 25.552 1.00 39.38 ? 50  VAL A CA    1 
ATOM   368  C C     . VAL A 1 50 ? 3.082   -11.641 24.609 1.00 23.07 ? 50  VAL A C     1 
ATOM   369  O O     . VAL A 1 50 ? 3.456   -10.536 25.004 1.00 25.36 ? 50  VAL A O     1 
ATOM   370  C CB    . VAL A 1 50 ? 1.512   -13.215 25.796 1.00 43.45 ? 50  VAL A CB    1 
ATOM   371  C CG1   . VAL A 1 50 ? 1.412   -14.360 26.790 1.00 36.93 ? 50  VAL A CG1   1 
ATOM   372  C CG2   . VAL A 1 50 ? 0.719   -12.006 26.275 1.00 34.94 ? 50  VAL A CG2   1 
ATOM   373  N N     . SER A 1 51 ? 2.729   -11.875 23.349 1.00 16.31 ? 51  SER A N     1 
ATOM   374  C CA    . SER A 1 51 ? 2.759   -10.842 22.320 1.00 29.96 ? 51  SER A CA    1 
ATOM   375  C C     . SER A 1 51 ? 1.358   -10.255 22.183 1.00 38.14 ? 51  SER A C     1 
ATOM   376  O O     . SER A 1 51 ? 0.446   -10.921 21.685 1.00 32.68 ? 51  SER A O     1 
ATOM   377  C CB    . SER A 1 51 ? 3.249   -11.415 20.993 1.00 23.76 ? 51  SER A CB    1 
ATOM   378  O OG    . SER A 1 51 ? 3.071   -10.485 19.942 1.00 58.64 ? 51  SER A OG    1 
ATOM   379  N N     . GLN A 1 52 ? 1.192   -9.012  22.624 1.00 23.23 ? 52  GLN A N     1 
ATOM   380  C CA    . GLN A 1 52 ? -0.092  -8.329  22.596 1.00 19.43 ? 52  GLN A CA    1 
ATOM   381  C C     . GLN A 1 52 ? -0.129  -7.290  21.481 1.00 13.09 ? 52  GLN A C     1 
ATOM   382  O O     . GLN A 1 52 ? 0.903   -6.798  21.020 1.00 14.02 ? 52  GLN A O     1 
ATOM   383  C CB    . GLN A 1 52 ? -0.374  -7.653  23.940 1.00 7.69  ? 52  GLN A CB    1 
ATOM   384  C CG    . GLN A 1 52 ? 0.517   -6.456  24.225 1.00 12.01 ? 52  GLN A CG    1 
ATOM   385  C CD    . GLN A 1 52 ? 0.465   -6.024  25.677 1.00 6.30  ? 52  GLN A CD    1 
ATOM   386  O OE1   . GLN A 1 52 ? -0.610  -5.864  26.251 1.00 13.41 ? 52  GLN A OE1   1 
ATOM   387  N NE2   . GLN A 1 52 ? 1.631   -5.834  26.279 1.00 30.44 ? 52  GLN A NE2   1 
ATOM   388  N N     . MET A 1 53 ? -1.344  -6.953  21.060 1.00 8.11  ? 53  MET A N     1 
ATOM   389  C CA    . MET A 1 53 ? -1.581  -6.012  19.972 1.00 15.86 ? 53  MET A CA    1 
ATOM   390  C C     . MET A 1 53 ? -2.113  -4.711  20.555 1.00 23.15 ? 53  MET A C     1 
ATOM   391  O O     . MET A 1 53 ? -3.193  -4.692  21.155 1.00 18.00 ? 53  MET A O     1 
ATOM   392  C CB    . MET A 1 53 ? -2.565  -6.597  18.958 1.00 22.18 ? 53  MET A CB    1 
ATOM   393  C CG    . MET A 1 53 ? -3.164  -5.583  18.000 1.00 15.88 ? 53  MET A CG    1 
ATOM   394  S SD    . MET A 1 53 ? -4.170  -6.367  16.724 1.00 11.29 ? 53  MET A SD    1 
ATOM   395  C CE    . MET A 1 53 ? -5.819  -5.979  17.303 1.00 10.11 ? 53  MET A CE    1 
ATOM   396  N N     . VAL A 1 54 ? -1.361  -3.629  20.370 1.00 31.58 ? 54  VAL A N     1 
ATOM   397  C CA    . VAL A 1 54 ? -1.703  -2.317  20.908 1.00 13.63 ? 54  VAL A CA    1 
ATOM   398  C C     . VAL A 1 54 ? -2.168  -1.431  19.760 1.00 16.95 ? 54  VAL A C     1 
ATOM   399  O O     . VAL A 1 54 ? -1.470  -1.300  18.747 1.00 18.09 ? 54  VAL A O     1 
ATOM   400  C CB    . VAL A 1 54 ? -0.506  -1.685  21.641 1.00 9.57  ? 54  VAL A CB    1 
ATOM   401  C CG1   . VAL A 1 54 ? -0.925  -0.399  22.339 1.00 10.55 ? 54  VAL A CG1   1 
ATOM   402  C CG2   . VAL A 1 54 ? 0.095   -2.675  22.635 1.00 9.13  ? 54  VAL A CG2   1 
ATOM   403  N N     . TYR A 1 55 ? -3.347  -0.825  19.917 1.00 22.89 ? 55  TYR A N     1 
ATOM   404  C CA    . TYR A 1 55 ? -3.886  0.072   18.900 1.00 13.64 ? 55  TYR A CA    1 
ATOM   405  C C     . TYR A 1 55 ? -3.190  1.426   18.983 1.00 16.63 ? 55  TYR A C     1 
ATOM   406  O O     . TYR A 1 55 ? -3.019  1.980   20.073 1.00 8.66  ? 55  TYR A O     1 
ATOM   407  C CB    . TYR A 1 55 ? -5.399  0.238   19.067 1.00 13.25 ? 55  TYR A CB    1 
ATOM   408  C CG    . TYR A 1 55 ? -6.192  -0.896  18.455 1.00 13.63 ? 55  TYR A CG    1 
ATOM   409  C CD1   . TYR A 1 55 ? -6.324  -1.012  17.076 1.00 11.73 ? 55  TYR A CD1   1 
ATOM   410  C CD2   . TYR A 1 55 ? -6.800  -1.855  19.254 1.00 24.57 ? 55  TYR A CD2   1 
ATOM   411  C CE1   . TYR A 1 55 ? -7.038  -2.054  16.513 1.00 12.91 ? 55  TYR A CE1   1 
ATOM   412  C CE2   . TYR A 1 55 ? -7.513  -2.896  18.703 1.00 30.01 ? 55  TYR A CE2   1 
ATOM   413  C CZ    . TYR A 1 55 ? -7.632  -2.992  17.334 1.00 14.00 ? 55  TYR A CZ    1 
ATOM   414  O OH    . TYR A 1 55 ? -8.347  -4.036  16.795 1.00 13.10 ? 55  TYR A OH    1 
ATOM   415  N N     . LYS A 1 56 ? -2.790  1.957   17.825 1.00 6.55  ? 56  LYS A N     1 
ATOM   416  C CA    . LYS A 1 56 ? -2.033  3.204   17.803 1.00 11.56 ? 56  LYS A CA    1 
ATOM   417  C C     . LYS A 1 56 ? -2.852  4.372   18.326 1.00 12.59 ? 56  LYS A C     1 
ATOM   418  O O     . LYS A 1 56 ? -2.297  5.315   18.903 1.00 7.25  ? 56  LYS A O     1 
ATOM   419  C CB    . LYS A 1 56 ? -1.558  3.506   16.384 1.00 11.15 ? 56  LYS A CB    1 
ATOM   420  C CG    . LYS A 1 56 ? -0.215  2.897   16.034 1.00 9.13  ? 56  LYS A CG    1 
ATOM   421  C CD    . LYS A 1 56 ? 0.262   3.374   14.670 1.00 15.19 ? 56  LYS A CD    1 
ATOM   422  C CE    . LYS A 1 56 ? 1.368   2.485   14.124 1.00 19.11 ? 56  LYS A CE    1 
ATOM   423  N NZ    . LYS A 1 56 ? 1.654   2.762   12.686 1.00 28.53 ? 56  LYS A NZ    1 
ATOM   424  N N     . HIS A 1 57 ? -4.168  4.334   18.132 1.00 10.46 ? 57  HIS A N     1 
ATOM   425  C CA    . HIS A 1 57 ? -4.990  5.455   18.552 1.00 8.10  ? 57  HIS A CA    1 
ATOM   426  C C     . HIS A 1 57 ? -5.095  5.583   20.058 1.00 20.23 ? 57  HIS A C     1 
ATOM   427  O O     . HIS A 1 57 ? -5.478  6.652   20.545 1.00 6.58  ? 57  HIS A O     1 
ATOM   428  C CB    . HIS A 1 57 ? -6.391  5.328   17.988 1.00 9.45  ? 57  HIS A CB    1 
ATOM   429  C CG    . HIS A 1 57 ? -7.067  4.025   18.301 1.00 10.95 ? 57  HIS A CG    1 
ATOM   430  N ND1   . HIS A 1 57 ? -7.501  3.174   17.308 1.00 6.29  ? 57  HIS A ND1   1 
ATOM   431  C CD2   . HIS A 1 57 ? -7.427  3.457   19.476 1.00 6.18  ? 57  HIS A CD2   1 
ATOM   432  C CE1   . HIS A 1 57 ? -8.098  2.133   17.862 1.00 14.37 ? 57  HIS A CE1   1 
ATOM   433  N NE2   . HIS A 1 57 ? -8.062  2.273   19.172 1.00 9.50  ? 57  HIS A NE2   1 
ATOM   434  N N     . ALA A 1 58 ? -4.809  4.512   20.796 1.00 5.62  ? 58  ALA A N     1 
ATOM   435  C CA    . ALA A 1 58 ? -4.847  4.524   22.249 1.00 11.86 ? 58  ALA A CA    1 
ATOM   436  C C     . ALA A 1 58 ? -3.469  4.698   22.874 1.00 15.68 ? 58  ALA A C     1 
ATOM   437  O O     . ALA A 1 58 ? -3.328  4.525   24.088 1.00 21.76 ? 58  ALA A O     1 
ATOM   438  C CB    . ALA A 1 58 ? -5.492  3.237   22.765 1.00 7.45  ? 58  ALA A CB    1 
ATOM   439  N N     . ILE A 1 59 ? -2.454  5.034   22.081 1.00 6.01  ? 59  ILE A N     1 
ATOM   440  C CA    . ILE A 1 59 ? -1.118  5.326   22.588 1.00 18.99 ? 59  ILE A CA    1 
ATOM   441  C C     . ILE A 1 59 ? -0.925  6.834   22.609 1.00 11.20 ? 59  ILE A C     1 
ATOM   442  O O     . ILE A 1 59 ? -1.364  7.540   21.692 1.00 21.27 ? 59  ILE A O     1 
ATOM   443  C CB    . ILE A 1 59 ? -0.026  4.655   21.733 1.00 19.14 ? 59  ILE A CB    1 
ATOM   444  C CG1   . ILE A 1 59 ? -0.214  3.138   21.701 1.00 12.49 ? 59  ILE A CG1   1 
ATOM   445  C CG2   . ILE A 1 59 ? 1.353   5.030   22.254 1.00 7.10  ? 59  ILE A CG2   1 
ATOM   446  C CD1   . ILE A 1 59 ? 0.635   2.448   20.652 1.00 17.99 ? 59  ILE A CD1   1 
ATOM   447  N N     . SER A 1 60 ? -0.270  7.332   23.656 1.00 18.57 ? 60  SER A N     1 
ATOM   448  C CA    . SER A 1 60 ? 0.137   8.730   23.716 1.00 12.00 ? 60  SER A CA    1 
ATOM   449  C C     . SER A 1 60 ? 1.611   8.907   23.371 1.00 11.58 ? 60  SER A C     1 
ATOM   450  O O     . SER A 1 60 ? 1.957   9.788   22.580 1.00 14.04 ? 60  SER A O     1 
ATOM   451  C CB    . SER A 1 60 ? -0.152  9.314   25.104 1.00 17.70 ? 60  SER A CB    1 
ATOM   452  O OG    . SER A 1 60 ? 0.496   8.577   26.124 1.00 19.45 ? 60  SER A OG    1 
ATOM   453  N N     . THR A 1 61 ? 2.490   8.079   23.936 1.00 7.95  ? 61  THR A N     1 
ATOM   454  C CA    . THR A 1 61 ? 3.917   8.185   23.669 1.00 21.52 ? 61  THR A CA    1 
ATOM   455  C C     . THR A 1 61 ? 4.530   6.795   23.556 1.00 19.72 ? 61  THR A C     1 
ATOM   456  O O     . THR A 1 61 ? 3.972   5.800   24.029 1.00 20.77 ? 61  THR A O     1 
ATOM   457  C CB    . THR A 1 61 ? 4.648   8.986   24.764 1.00 11.91 ? 61  THR A CB    1 
ATOM   458  O OG1   . THR A 1 61 ? 4.751   8.193   25.954 1.00 23.79 ? 61  THR A OG1   1 
ATOM   459  C CG2   . THR A 1 61 ? 3.906   10.280  25.070 1.00 11.43 ? 61  THR A CG2   1 
ATOM   460  N N     . VAL A 1 62 ? 5.719   6.755   22.958 1.00 25.05 ? 62  VAL A N     1 
ATOM   461  C CA    . VAL A 1 62 ? 6.574   5.573   22.923 1.00 20.66 ? 62  VAL A CA    1 
ATOM   462  C C     . VAL A 1 62 ? 7.969   6.034   23.324 1.00 19.90 ? 62  VAL A C     1 
ATOM   463  O O     . VAL A 1 62 ? 8.636   6.743   22.560 1.00 15.04 ? 62  VAL A O     1 
ATOM   464  C CB    . VAL A 1 62 ? 6.598   4.901   21.544 1.00 24.69 ? 62  VAL A CB    1 
ATOM   465  C CG1   . VAL A 1 62 ? 7.561   3.721   21.551 1.00 22.89 ? 62  VAL A CG1   1 
ATOM   466  C CG2   . VAL A 1 62 ? 5.202   4.447   21.149 1.00 27.90 ? 62  VAL A CG2   1 
ATOM   467  N N     . VAL A 1 63 ? 8.415   5.631   24.506 1.00 26.60 ? 63  VAL A N     1 
ATOM   468  C CA    . VAL A 1 63 ? 9.679   6.086   25.075 1.00 27.22 ? 63  VAL A CA    1 
ATOM   469  C C     . VAL A 1 63 ? 10.687  4.943   24.989 1.00 32.57 ? 63  VAL A C     1 
ATOM   470  O O     . VAL A 1 63 ? 10.423  3.853   25.515 1.00 13.04 ? 63  VAL A O     1 
ATOM   471  C CB    . VAL A 1 63 ? 9.509   6.556   26.529 1.00 28.53 ? 63  VAL A CB    1 
ATOM   472  C CG1   . VAL A 1 63 ? 10.856  6.958   27.124 1.00 21.33 ? 63  VAL A CG1   1 
ATOM   473  C CG2   . VAL A 1 63 ? 8.525   7.714   26.608 1.00 38.70 ? 63  VAL A CG2   1 
ATOM   474  N N     . PRO A 1 64 ? 11.845  5.142   24.358 1.00 38.45 ? 64  PRO A N     1 
ATOM   475  C CA    . PRO A 1 64 ? 12.900  4.122   24.432 1.00 27.49 ? 64  PRO A CA    1 
ATOM   476  C C     . PRO A 1 64 ? 13.550  4.100   25.809 1.00 22.09 ? 64  PRO A C     1 
ATOM   477  O O     . PRO A 1 64 ? 13.756  5.141   26.437 1.00 17.75 ? 64  PRO A O     1 
ATOM   478  C CB    . PRO A 1 64 ? 13.895  4.556   23.344 1.00 36.20 ? 64  PRO A CB    1 
ATOM   479  C CG    . PRO A 1 64 ? 13.121  5.503   22.459 1.00 31.27 ? 64  PRO A CG    1 
ATOM   480  C CD    . PRO A 1 64 ? 12.184  6.205   23.396 1.00 33.20 ? 64  PRO A CD    1 
ATOM   481  N N     . SER A 1 65 ? 13.868  2.892   26.280 1.00 16.44 ? 65  SER A N     1 
ATOM   482  C CA    . SER A 1 65 ? 14.495  2.749   27.590 1.00 37.33 ? 65  SER A CA    1 
ATOM   483  C C     . SER A 1 65 ? 15.882  3.376   27.638 1.00 37.69 ? 65  SER A C     1 
ATOM   484  O O     . SER A 1 65 ? 16.416  3.593   28.732 1.00 25.23 ? 65  SER A O     1 
ATOM   485  C CB    . SER A 1 65 ? 14.585  1.270   27.972 1.00 32.25 ? 65  SER A CB    1 
ATOM   486  O OG    . SER A 1 65 ? 15.483  0.579   27.120 1.00 28.97 ? 65  SER A OG    1 
ATOM   487  N N     . ARG A 1 66 ? 16.541  3.573   26.527 1.00 27.38 ? 66  ARG A N     1 
ATOM   488  C CA    . ARG A 1 66 ? 17.857  4.228   26.495 1.00 38.88 ? 66  ARG A CA    1 
ATOM   489  C C     . ARG A 1 66 ? 17.950  4.968   25.168 1.00 34.25 ? 66  ARG A C     1 
ATOM   490  O O     . ARG A 1 66 ? 17.224  4.593   24.258 1.00 37.98 ? 66  ARG A O     1 
ATOM   491  C CB    . ARG A 1 66 ? 18.963  3.189   26.642 1.00 40.12 ? 66  ARG A CB    1 
ATOM   492  C CG    . ARG A 1 66 ? 18.500  1.751   26.459 1.00 50.06 ? 66  ARG A CG    1 
ATOM   493  C CD    . ARG A 1 66 ? 19.682  0.806   26.479 1.00 34.50 ? 66  ARG A CD    1 
ATOM   494  N NE    . ARG A 1 66 ? 19.871  0.143   25.196 1.00 51.87 ? 66  ARG A NE    1 
ATOM   495  C CZ    . ARG A 1 66 ? 19.327  -1.016  24.847 1.00 45.26 ? 66  ARG A CZ    1 
ATOM   496  N NH1   . ARG A 1 66 ? 18.792  -1.812  25.752 1.00 39.16 ? 66  ARG A NH1   1 
ATOM   497  N NH2   . ARG A 1 66 ? 19.321  -1.380  23.580 1.00 41.61 ? 66  ARG A NH2   1 
ATOM   498  N N     . PRO A 1 67 ? 18.801  5.997   25.049 1.00 34.58 ? 67  PRO A N     1 
ATOM   499  C CA    . PRO A 1 67 ? 18.945  6.716   23.798 1.00 48.00 ? 67  PRO A CA    1 
ATOM   500  C C     . PRO A 1 67 ? 19.164  5.728   22.646 1.00 55.00 ? 67  PRO A C     1 
ATOM   501  O O     . PRO A 1 67 ? 19.779  4.720   22.887 1.00 76.27 ? 67  PRO A O     1 
ATOM   502  C CB    . PRO A 1 67 ? 20.137  7.643   24.025 1.00 26.10 ? 67  PRO A CB    1 
ATOM   503  C CG    . PRO A 1 67 ? 20.754  7.202   25.331 1.00 45.01 ? 67  PRO A CG    1 
ATOM   504  C CD    . PRO A 1 67 ? 19.645  6.532   26.105 1.00 28.88 ? 67  PRO A CD    1 
ATOM   505  N N     . VAL A 1 68 ? 18.658  6.020   21.449 1.00 57.66 ? 68  VAL A N     1 
ATOM   506  C CA    . VAL A 1 68 ? 18.777  5.111   20.272 1.00 53.96 ? 68  VAL A CA    1 
ATOM   507  C C     . VAL A 1 68 ? 19.246  5.933   19.077 1.00 74.28 ? 68  VAL A C     1 
ATOM   508  O O     . VAL A 1 68 ? 18.673  6.991   18.859 1.00 76.85 ? 68  VAL A O     1 
ATOM   509  C CB    . VAL A 1 68 ? 17.470  4.366   19.932 1.00 60.74 ? 68  VAL A CB    1 
ATOM   510  C CG1   . VAL A 1 68 ? 17.546  3.713   18.563 1.00 55.33 ? 68  VAL A CG1   1 
ATOM   511  C CG2   . VAL A 1 68 ? 17.102  3.348   20.995 1.00 61.19 ? 68  VAL A CG2   1 
ATOM   512  N N     . SER A 1 69 ? 20.206  5.413   18.301 1.00 83.60 ? 69  SER A N     1 
ATOM   513  C CA    . SER A 1 69 ? 20.789  6.119   17.168 1.00 86.94 ? 69  SER A CA    1 
ATOM   514  C C     . SER A 1 69 ? 19.691  6.652   16.255 1.00 87.99 ? 69  SER A C     1 
ATOM   515  O O     . SER A 1 69 ? 18.785  5.915   15.856 1.00 79.04 ? 69  SER A O     1 
ATOM   516  C CB    . SER A 1 69 ? 21.720  5.188   16.390 1.00 76.16 ? 69  SER A CB    1 
ATOM   517  O OG    . SER A 1 69 ? 22.960  5.032   17.057 1.00 59.82 ? 69  SER A OG    1 
ATOM   518  N N     . SER B 1 6  ? -2.597  -4.466  7.949  1.00 52.69 ? 6   SER B N     1 
ATOM   519  C CA    . SER B 1 6  ? -1.953  -5.518  7.171  1.00 47.11 ? 6   SER B CA    1 
ATOM   520  C C     . SER B 1 6  ? -1.561  -6.697  8.055  1.00 55.98 ? 6   SER B C     1 
ATOM   521  O O     . SER B 1 6  ? -1.269  -7.786  7.559  1.00 53.14 ? 6   SER B O     1 
ATOM   522  C CB    . SER B 1 6  ? -0.719  -4.971  6.453  1.00 53.85 ? 6   SER B CB    1 
ATOM   523  O OG    . SER B 1 6  ? 0.261   -5.981  6.291  1.00 19.41 ? 6   SER B OG    1 
ATOM   524  N N     . LEU B 1 7  ? -1.554  -6.472  9.371  1.00 41.08 ? 7   LEU B N     1 
ATOM   525  C CA    . LEU B 1 7  ? -1.243  -7.523  10.325 1.00 38.32 ? 7   LEU B CA    1 
ATOM   526  C C     . LEU B 1 7  ? -2.213  -7.575  11.497 1.00 33.04 ? 7   LEU B C     1 
ATOM   527  O O     . LEU B 1 7  ? -2.082  -8.463  12.346 1.00 47.85 ? 7   LEU B O     1 
ATOM   528  C CB    . LEU B 1 7  ? 0.190   -7.360  10.856 1.00 47.23 ? 7   LEU B CB    1 
ATOM   529  C CG    . LEU B 1 7  ? 0.502   -6.181  11.776 1.00 39.33 ? 7   LEU B CG    1 
ATOM   530  C CD1   . LEU B 1 7  ? 0.116   -6.481  13.211 1.00 32.40 ? 7   LEU B CD1   1 
ATOM   531  C CD2   . LEU B 1 7  ? 1.983   -5.840  11.687 1.00 48.87 ? 7   LEU B CD2   1 
ATOM   532  N N     . GLN B 1 8  ? -3.171  -6.651  11.580 1.00 37.16 ? 8   GLN B N     1 
ATOM   533  C CA    . GLN B 1 8  ? -4.170  -6.729  12.640 1.00 28.89 ? 8   GLN B CA    1 
ATOM   534  C C     . GLN B 1 8  ? -5.052  -7.958  12.471 1.00 22.30 ? 8   GLN B C     1 
ATOM   535  O O     . GLN B 1 8  ? -5.384  -8.635  13.453 1.00 11.92 ? 8   GLN B O     1 
ATOM   536  C CB    . GLN B 1 8  ? -5.025  -5.463  12.645 1.00 29.11 ? 8   GLN B CB    1 
ATOM   537  C CG    . GLN B 1 8  ? -6.190  -5.494  13.618 1.00 28.96 ? 8   GLN B CG    1 
ATOM   538  C CD    . GLN B 1 8  ? -7.033  -4.230  13.565 1.00 28.16 ? 8   GLN B CD    1 
ATOM   539  O OE1   . GLN B 1 8  ? -7.813  -3.956  14.475 1.00 14.64 ? 8   GLN B OE1   1 
ATOM   540  N NE2   . GLN B 1 8  ? -6.883  -3.457  12.494 1.00 31.27 ? 8   GLN B NE2   1 
ATOM   541  N N     . ASP B 1 9  ? -5.455  -8.253  11.237 1.00 15.62 ? 9   ASP B N     1 
ATOM   542  C CA    . ASP B 1 9  ? -6.338  -9.391  11.000 1.00 27.39 ? 9   ASP B CA    1 
ATOM   543  C C     . ASP B 1 9  ? -5.681  -10.715 11.356 1.00 27.88 ? 9   ASP B C     1 
ATOM   544  O O     . ASP B 1 9  ? -6.289  -11.498 12.107 1.00 34.78 ? 9   ASP B O     1 
ATOM   545  C CB    . ASP B 1 9  ? -6.805  -9.378  9.542  1.00 33.09 ? 9   ASP B CB    1 
ATOM   546  C CG    . ASP B 1 9  ? -7.950  -8.413  9.308  1.00 31.05 ? 9   ASP B CG    1 
ATOM   547  O OD1   . ASP B 1 9  ? -7.731  -7.189  9.426  1.00 17.40 ? 9   ASP B OD1   1 
ATOM   548  O OD2   . ASP B 1 9  ? -9.071  -8.878  9.011  1.00 38.67 ? 9   ASP B OD2   1 
ATOM   549  N N     . PRO B 1 10 ? -4.481  -11.040 10.869 1.00 31.78 ? 10  PRO B N     1 
ATOM   550  C CA    . PRO B 1 10 ? -3.854  -12.310 11.273 1.00 21.89 ? 10  PRO B CA    1 
ATOM   551  C C     . PRO B 1 10 ? -3.756  -12.481 12.779 1.00 19.11 ? 10  PRO B C     1 
ATOM   552  O O     . PRO B 1 10 ? -3.891  -13.607 13.278 1.00 27.75 ? 10  PRO B O     1 
ATOM   553  C CB    . PRO B 1 10 ? -2.466  -12.249 10.613 1.00 25.44 ? 10  PRO B CB    1 
ATOM   554  C CG    . PRO B 1 10 ? -2.283  -10.825 10.182 1.00 33.04 ? 10  PRO B CG    1 
ATOM   555  C CD    . PRO B 1 10 ? -3.654  -10.299 9.902  1.00 32.37 ? 10  PRO B CD    1 
ATOM   556  N N     . PHE B 1 11 ? -3.534  -11.396 13.523 1.00 30.96 ? 11  PHE B N     1 
ATOM   557  C CA    . PHE B 1 11 ? -3.499  -11.485 14.979 1.00 27.94 ? 11  PHE B CA    1 
ATOM   558  C C     . PHE B 1 11 ? -4.847  -11.938 15.527 1.00 24.99 ? 11  PHE B C     1 
ATOM   559  O O     . PHE B 1 11 ? -4.960  -13.007 16.137 1.00 23.34 ? 11  PHE B O     1 
ATOM   560  C CB    . PHE B 1 11 ? -3.100  -10.134 15.577 1.00 17.85 ? 11  PHE B CB    1 
ATOM   561  C CG    . PHE B 1 11 ? -2.888  -10.168 17.067 1.00 11.35 ? 11  PHE B CG    1 
ATOM   562  C CD1   . PHE B 1 11 ? -1.644  -10.467 17.597 1.00 27.71 ? 11  PHE B CD1   1 
ATOM   563  C CD2   . PHE B 1 11 ? -3.932  -9.899  17.936 1.00 16.70 ? 11  PHE B CD2   1 
ATOM   564  C CE1   . PHE B 1 11 ? -1.447  -10.499 18.966 1.00 22.49 ? 11  PHE B CE1   1 
ATOM   565  C CE2   . PHE B 1 11 ? -3.740  -9.929  19.306 1.00 9.13  ? 11  PHE B CE2   1 
ATOM   566  C CZ    . PHE B 1 11 ? -2.497  -10.230 19.820 1.00 23.32 ? 11  PHE B CZ    1 
ATOM   567  N N     . LEU B 1 12 ? -5.887  -11.127 15.321 1.00 25.86 ? 12  LEU B N     1 
ATOM   568  C CA    . LEU B 1 12 ? -7.213  -11.492 15.805 1.00 21.10 ? 12  LEU B CA    1 
ATOM   569  C C     . LEU B 1 12 ? -7.645  -12.844 15.252 1.00 18.17 ? 12  LEU B C     1 
ATOM   570  O O     . LEU B 1 12 ? -8.215  -13.669 15.976 1.00 18.10 ? 12  LEU B O     1 
ATOM   571  C CB    . LEU B 1 12 ? -8.228  -10.414 15.420 1.00 13.17 ? 12  LEU B CB    1 
ATOM   572  C CG    . LEU B 1 12 ? -7.921  -8.955  15.759 1.00 29.88 ? 12  LEU B CG    1 
ATOM   573  C CD1   . LEU B 1 12 ? -8.432  -8.046  14.649 1.00 19.99 ? 12  LEU B CD1   1 
ATOM   574  C CD2   . LEU B 1 12 ? -8.549  -8.570  17.088 1.00 19.46 ? 12  LEU B CD2   1 
ATOM   575  N N     . ASN B 1 13 ? -7.379  -13.091 13.969 1.00 27.60 ? 13  ASN B N     1 
ATOM   576  C CA    . ASN B 1 13 ? -7.796  -14.348 13.358 1.00 27.84 ? 13  ASN B CA    1 
ATOM   577  C C     . ASN B 1 13 ? -7.187  -15.543 14.077 1.00 39.02 ? 13  ASN B C     1 
ATOM   578  O O     . ASN B 1 13 ? -7.863  -16.554 14.303 1.00 28.90 ? 13  ASN B O     1 
ATOM   579  C CB    . ASN B 1 13 ? -7.406  -14.360 11.881 1.00 42.92 ? 13  ASN B CB    1 
ATOM   580  C CG    . ASN B 1 13 ? -8.444  -13.693 10.995 1.00 43.48 ? 13  ASN B CG    1 
ATOM   581  O OD1   . ASN B 1 13 ? -9.647  -13.897 11.164 1.00 44.14 ? 13  ASN B OD1   1 
ATOM   582  N ND2   . ASN B 1 13 ? -7.982  -12.886 10.044 1.00 51.22 ? 13  ASN B ND2   1 
ATOM   583  N N     . ALA B 1 14 ? -5.902  -15.456 14.428 1.00 33.27 ? 14  ALA B N     1 
ATOM   584  C CA    . ALA B 1 14 ? -5.269  -16.537 15.173 1.00 37.60 ? 14  ALA B CA    1 
ATOM   585  C C     . ALA B 1 14 ? -6.011  -16.805 16.475 1.00 33.73 ? 14  ALA B C     1 
ATOM   586  O O     . ALA B 1 14 ? -6.204  -17.963 16.864 1.00 28.35 ? 14  ALA B O     1 
ATOM   587  C CB    . ALA B 1 14 ? -3.804  -16.199 15.452 1.00 25.13 ? 14  ALA B CB    1 
ATOM   588  N N     . LEU B 1 15 ? -6.438  -15.743 17.163 1.00 26.53 ? 15  LEU B N     1 
ATOM   589  C CA    . LEU B 1 15 ? -7.198  -15.923 18.394 1.00 36.73 ? 15  LEU B CA    1 
ATOM   590  C C     . LEU B 1 15 ? -8.520  -16.628 18.128 1.00 42.20 ? 15  LEU B C     1 
ATOM   591  O O     . LEU B 1 15 ? -9.041  -17.323 19.008 1.00 12.62 ? 15  LEU B O     1 
ATOM   592  C CB    . LEU B 1 15 ? -7.451  -14.571 19.061 1.00 19.24 ? 15  LEU B CB    1 
ATOM   593  C CG    . LEU B 1 15 ? -6.322  -13.983 19.908 1.00 29.97 ? 15  LEU B CG    1 
ATOM   594  C CD1   . LEU B 1 15 ? -4.969  -14.197 19.249 1.00 32.38 ? 15  LEU B CD1   1 
ATOM   595  C CD2   . LEU B 1 15 ? -6.573  -12.500 20.147 1.00 30.64 ? 15  LEU B CD2   1 
ATOM   596  N N     . ARG B 1 16 ? -9.079  -16.461 16.927 1.00 32.88 ? 16  ARG B N     1 
ATOM   597  C CA    . ARG B 1 16 ? -10.320 -17.145 16.585 1.00 30.30 ? 16  ARG B CA    1 
ATOM   598  C C     . ARG B 1 16 ? -10.069 -18.613 16.263 1.00 21.75 ? 16  ARG B C     1 
ATOM   599  O O     . ARG B 1 16 ? -10.818 -19.486 16.705 1.00 32.13 ? 16  ARG B O     1 
ATOM   600  C CB    . ARG B 1 16 ? -11.000 -16.455 15.403 1.00 33.23 ? 16  ARG B CB    1 
ATOM   601  C CG    . ARG B 1 16 ? -12.482 -16.779 15.268 1.00 29.81 ? 16  ARG B CG    1 
ATOM   602  C CD    . ARG B 1 16 ? -13.147 -15.903 14.218 1.00 38.33 ? 16  ARG B CD    1 
ATOM   603  N NE    . ARG B 1 16 ? -12.312 -15.744 13.033 1.00 31.62 ? 16  ARG B NE    1 
ATOM   604  C CZ    . ARG B 1 16 ? -12.134 -16.680 12.111 1.00 45.45 ? 16  ARG B CZ    1 
ATOM   605  N NH1   . ARG B 1 16 ? -12.724 -17.861 12.200 1.00 42.16 ? 16  ARG B NH1   1 
ATOM   606  N NH2   . ARG B 1 16 ? -11.341 -16.426 11.073 1.00 35.55 ? 16  ARG B NH2   1 
ATOM   607  N N     . ARG B 1 17 ? -9.029  -18.905 15.482 1.00 36.93 ? 17  ARG B N     1 
ATOM   608  C CA    . ARG B 1 17 ? -8.706  -20.292 15.166 1.00 36.02 ? 17  ARG B CA    1 
ATOM   609  C C     . ARG B 1 17 ? -8.499  -21.110 16.437 1.00 25.66 ? 17  ARG B C     1 
ATOM   610  O O     . ARG B 1 17 ? -9.139  -22.147 16.645 1.00 41.48 ? 17  ARG B O     1 
ATOM   611  C CB    . ARG B 1 17 ? -7.448  -20.351 14.295 1.00 44.51 ? 17  ARG B CB    1 
ATOM   612  C CG    . ARG B 1 17 ? -7.687  -20.508 12.802 1.00 43.48 ? 17  ARG B CG    1 
ATOM   613  C CD    . ARG B 1 17 ? -6.382  -20.861 12.094 1.00 40.10 ? 17  ARG B CD    1 
ATOM   614  N NE    . ARG B 1 17 ? -5.226  -20.620 12.952 1.00 50.89 ? 17  ARG B NE    1 
ATOM   615  C CZ    . ARG B 1 17 ? -4.454  -19.542 12.902 1.00 40.28 ? 17  ARG B CZ    1 
ATOM   616  N NH1   . ARG B 1 17 ? -4.653  -18.587 12.008 1.00 37.79 ? 17  ARG B NH1   1 
ATOM   617  N NH2   . ARG B 1 17 ? -3.449  -19.426 13.765 1.00 33.47 ? 17  ARG B NH2   1 
ATOM   618  N N     . GLU B 1 18 ? -7.599  -20.640 17.304 1.00 30.20 ? 18  GLU B N     1 
ATOM   619  C CA    . GLU B 1 18 ? -7.221  -21.403 18.486 1.00 37.43 ? 18  GLU B CA    1 
ATOM   620  C C     . GLU B 1 18 ? -8.302  -21.405 19.558 1.00 33.17 ? 18  GLU B C     1 
ATOM   621  O O     . GLU B 1 18 ? -8.260  -22.251 20.457 1.00 31.74 ? 18  GLU B O     1 
ATOM   622  C CB    . GLU B 1 18 ? -5.923  -20.843 19.070 1.00 39.07 ? 18  GLU B CB    1 
ATOM   623  C CG    . GLU B 1 18 ? -4.666  -21.450 18.474 1.00 43.63 ? 18  GLU B CG    1 
ATOM   624  C CD    . GLU B 1 18 ? -4.514  -21.134 16.999 1.00 44.85 ? 18  GLU B CD    1 
ATOM   625  O OE1   . GLU B 1 18 ? -5.049  -21.899 16.169 1.00 38.38 ? 18  GLU B OE1   1 
ATOM   626  O OE2   . GLU B 1 18 ? -3.861  -20.122 16.667 1.00 37.79 ? 18  GLU B OE2   1 
ATOM   627  N N     . ARG B 1 19 ? -9.261  -20.483 19.493 1.00 23.18 ? 19  ARG B N     1 
ATOM   628  C CA    . ARG B 1 19 ? -10.299 -20.380 20.517 1.00 18.11 ? 19  ARG B CA    1 
ATOM   629  C C     . ARG B 1 19 ? -9.683  -20.075 21.882 1.00 17.15 ? 19  ARG B C     1 
ATOM   630  O O     . ARG B 1 19 ? -10.094 -20.620 22.908 1.00 11.98 ? 19  ARG B O     1 
ATOM   631  C CB    . ARG B 1 19 ? -11.144 -21.655 20.582 1.00 33.93 ? 19  ARG B CB    1 
ATOM   632  C CG    . ARG B 1 19 ? -11.778 -22.066 19.262 1.00 32.23 ? 19  ARG B CG    1 
ATOM   633  C CD    . ARG B 1 19 ? -12.609 -20.942 18.672 1.00 33.25 ? 19  ARG B CD    1 
ATOM   634  N NE    . ARG B 1 19 ? -13.917 -21.403 18.224 1.00 48.51 ? 19  ARG B NE    1 
ATOM   635  C CZ    . ARG B 1 19 ? -14.289 -21.505 16.955 1.00 48.80 ? 19  ARG B CZ    1 
ATOM   636  N NH1   . ARG B 1 19 ? -13.462 -21.215 15.963 1.00 51.71 ? 19  ARG B NH1   1 
ATOM   637  N NH2   . ARG B 1 19 ? -15.527 -21.900 16.672 1.00 44.90 ? 19  ARG B NH2   1 
ATOM   638  N N     . VAL B 1 20 ? -8.688  -19.192 21.895 1.00 34.78 ? 20  VAL B N     1 
ATOM   639  C CA    . VAL B 1 20 ? -7.957  -18.879 23.120 1.00 18.24 ? 20  VAL B CA    1 
ATOM   640  C C     . VAL B 1 20 ? -8.655  -17.733 23.842 1.00 17.94 ? 20  VAL B C     1 
ATOM   641  O O     . VAL B 1 20 ? -9.026  -16.736 23.204 1.00 7.50  ? 20  VAL B O     1 
ATOM   642  C CB    . VAL B 1 20 ? -6.486  -18.532 22.825 1.00 23.41 ? 20  VAL B CB    1 
ATOM   643  C CG1   . VAL B 1 20 ? -6.334  -17.835 21.476 1.00 33.43 ? 20  VAL B CG1   1 
ATOM   644  C CG2   . VAL B 1 20 ? -5.908  -17.661 23.934 1.00 17.44 ? 20  VAL B CG2   1 
ATOM   645  N N     . PRO B 1 21 ? -8.860  -17.825 25.158 1.00 20.25 ? 21  PRO B N     1 
ATOM   646  C CA    . PRO B 1 21 ? -9.420  -16.681 25.889 1.00 10.92 ? 21  PRO B CA    1 
ATOM   647  C C     . PRO B 1 21 ? -8.506  -15.469 25.786 1.00 15.53 ? 21  PRO B C     1 
ATOM   648  O O     . PRO B 1 21 ? -7.279  -15.588 25.827 1.00 8.72  ? 21  PRO B O     1 
ATOM   649  C CB    . PRO B 1 21 ? -9.531  -17.187 27.334 1.00 20.60 ? 21  PRO B CB    1 
ATOM   650  C CG    . PRO B 1 21 ? -8.685  -18.409 27.406 1.00 17.39 ? 21  PRO B CG    1 
ATOM   651  C CD    . PRO B 1 21 ? -8.610  -18.986 26.030 1.00 20.89 ? 21  PRO B CD    1 
ATOM   652  N N     . ALA B 1 22 ? -9.115  -14.294 25.645 1.00 15.69 ? 22  ALA B N     1 
ATOM   653  C CA    . ALA B 1 22 ? -8.383  -13.047 25.486 1.00 20.62 ? 22  ALA B CA    1 
ATOM   654  C C     . ALA B 1 22 ? -8.836  -12.067 26.563 1.00 22.46 ? 22  ALA B C     1 
ATOM   655  O O     . ALA B 1 22 ? -9.800  -12.305 27.291 1.00 22.70 ? 22  ALA B O     1 
ATOM   656  C CB    . ALA B 1 22 ? -8.590  -12.466 24.095 1.00 30.00 ? 22  ALA B CB    1 
ATOM   657  N N     . SER B 1 23 ? -8.120  -10.947 26.649 1.00 10.59 ? 23  SER B N     1 
ATOM   658  C CA    . SER B 1 23 ? -8.436  -9.881  27.598 1.00 16.12 ? 23  SER B CA    1 
ATOM   659  C C     . SER B 1 23 ? -8.325  -8.558  26.847 1.00 31.62 ? 23  SER B C     1 
ATOM   660  O O     . SER B 1 23 ? -7.218  -8.065  26.608 1.00 31.09 ? 23  SER B O     1 
ATOM   661  C CB    . SER B 1 23 ? -7.506  -9.915  28.804 1.00 15.33 ? 23  SER B CB    1 
ATOM   662  O OG    . SER B 1 23 ? -7.793  -11.025 29.635 1.00 18.78 ? 23  SER B OG    1 
ATOM   663  N N     . ILE B 1 24 ? -9.468  -7.995  26.472 1.00 26.08 ? 24  ILE B N     1 
ATOM   664  C CA    . ILE B 1 24 ? -9.512  -6.722  25.762 1.00 30.06 ? 24  ILE B CA    1 
ATOM   665  C C     . ILE B 1 24 ? -9.542  -5.601  26.791 1.00 15.48 ? 24  ILE B C     1 
ATOM   666  O O     . ILE B 1 24 ? -10.473 -5.511  27.599 1.00 8.81  ? 24  ILE B O     1 
ATOM   667  C CB    . ILE B 1 24 ? -10.729 -6.638  24.829 1.00 23.52 ? 24  ILE B CB    1 
ATOM   668  C CG1   . ILE B 1 24 ? -10.812 -7.874  23.933 1.00 18.19 ? 24  ILE B CG1   1 
ATOM   669  C CG2   . ILE B 1 24 ? -10.656 -5.375  23.981 1.00 18.46 ? 24  ILE B CG2   1 
ATOM   670  C CD1   . ILE B 1 24 ? -12.079 -7.937  23.111 1.00 11.97 ? 24  ILE B CD1   1 
ATOM   671  N N     . TYR B 1 25 ? -8.526  -4.747  26.762 1.00 13.13 ? 25  TYR B N     1 
ATOM   672  C CA    . TYR B 1 25 ? -8.467  -3.572  27.620 1.00 14.26 ? 25  TYR B CA    1 
ATOM   673  C C     . TYR B 1 25 ? -8.974  -2.370  26.834 1.00 11.88 ? 25  TYR B C     1 
ATOM   674  O O     . TYR B 1 25 ? -8.462  -2.071  25.750 1.00 12.24 ? 25  TYR B O     1 
ATOM   675  C CB    . TYR B 1 25 ? -7.045  -3.332  28.121 1.00 11.03 ? 25  TYR B CB    1 
ATOM   676  C CG    . TYR B 1 25 ? -6.545  -4.394  29.072 1.00 8.35  ? 25  TYR B CG    1 
ATOM   677  C CD1   . TYR B 1 25 ? -5.907  -5.532  28.599 1.00 12.63 ? 25  TYR B CD1   1 
ATOM   678  C CD2   . TYR B 1 25 ? -6.712  -4.257  30.443 1.00 10.59 ? 25  TYR B CD2   1 
ATOM   679  C CE1   . TYR B 1 25 ? -5.445  -6.503  29.465 1.00 7.56  ? 25  TYR B CE1   1 
ATOM   680  C CE2   . TYR B 1 25 ? -6.253  -5.222  31.316 1.00 6.44  ? 25  TYR B CE2   1 
ATOM   681  C CZ    . TYR B 1 25 ? -5.623  -6.343  30.822 1.00 7.78  ? 25  TYR B CZ    1 
ATOM   682  O OH    . TYR B 1 25 ? -5.166  -7.306  31.689 1.00 10.47 ? 25  TYR B OH    1 
ATOM   683  N N     . LEU B 1 26 ? -9.981  -1.695  27.375 1.00 16.18 ? 26  LEU B N     1 
ATOM   684  C CA    . LEU B 1 26 ? -10.567 -0.539  26.720 1.00 18.39 ? 26  LEU B CA    1 
ATOM   685  C C     . LEU B 1 26 ? -9.766  0.717   27.052 1.00 17.67 ? 26  LEU B C     1 
ATOM   686  O O     . LEU B 1 26 ? -8.932  0.737   27.961 1.00 7.81  ? 26  LEU B O     1 
ATOM   687  C CB    . LEU B 1 26 ? -12.027 -0.379  27.139 1.00 17.03 ? 26  LEU B CB    1 
ATOM   688  C CG    . LEU B 1 26 ? -12.912 -1.598  26.866 1.00 14.78 ? 26  LEU B CG    1 
ATOM   689  C CD1   . LEU B 1 26 ? -14.315 -1.384  27.411 1.00 8.49  ? 26  LEU B CD1   1 
ATOM   690  C CD2   . LEU B 1 26 ? -12.950 -1.908  25.376 1.00 18.47 ? 26  LEU B CD2   1 
ATOM   691  N N     . VAL B 1 27 ? -10.031 1.784   26.294 1.00 16.85 ? 27  VAL B N     1 
ATOM   692  C CA    . VAL B 1 27 ? -9.289  3.025   26.477 1.00 6.04  ? 27  VAL B CA    1 
ATOM   693  C C     . VAL B 1 27 ? -9.432  3.567   27.891 1.00 4.32  ? 27  VAL B C     1 
ATOM   694  O O     . VAL B 1 27 ? -8.619  4.391   28.320 1.00 7.10  ? 27  VAL B O     1 
ATOM   695  C CB    . VAL B 1 27 ? -9.741  4.084   25.452 1.00 18.09 ? 27  VAL B CB    1 
ATOM   696  C CG1   . VAL B 1 27 ? -9.200  3.747   24.083 1.00 7.35  ? 27  VAL B CG1   1 
ATOM   697  C CG2   . VAL B 1 27 ? -11.261 4.189   25.418 1.00 12.73 ? 27  VAL B CG2   1 
ATOM   698  N N     . ASN B 1 28 ? -10.451 3.129   28.628 1.00 8.92  ? 28  ASN B N     1 
ATOM   699  C CA    . ASN B 1 28 ? -10.676 3.573   29.996 1.00 6.73  ? 28  ASN B CA    1 
ATOM   700  C C     . ASN B 1 28 ? -10.189 2.562   31.028 1.00 8.82  ? 28  ASN B C     1 
ATOM   701  O O     . ASN B 1 28 ? -10.542 2.673   32.206 1.00 14.81 ? 28  ASN B O     1 
ATOM   702  C CB    . ASN B 1 28 ? -12.161 3.870   30.211 1.00 16.66 ? 28  ASN B CB    1 
ATOM   703  C CG    . ASN B 1 28 ? -13.031 2.637   30.066 1.00 13.72 ? 28  ASN B CG    1 
ATOM   704  O OD1   . ASN B 1 28 ? -12.586 1.602   29.573 1.00 13.24 ? 28  ASN B OD1   1 
ATOM   705  N ND2   . ASN B 1 28 ? -14.283 2.746   30.491 1.00 11.99 ? 28  ASN B ND2   1 
ATOM   706  N N     . GLY B 1 29 ? -9.386  1.582   30.615 1.00 13.66 ? 29  GLY B N     1 
ATOM   707  C CA    . GLY B 1 29 ? -8.797  0.631   31.530 1.00 6.82  ? 29  GLY B CA    1 
ATOM   708  C C     . GLY B 1 29 ? -9.644  -0.583  31.832 1.00 11.91 ? 29  GLY B C     1 
ATOM   709  O O     . GLY B 1 29 ? -9.129  -1.547  32.414 1.00 19.03 ? 29  GLY B O     1 
ATOM   710  N N     . ILE B 1 30 ? -10.926 -0.573  31.460 1.00 10.83 ? 30  ILE B N     1 
ATOM   711  C CA    . ILE B 1 30 ? -11.775 -1.727  31.716 1.00 19.09 ? 30  ILE B CA    1 
ATOM   712  C C     . ILE B 1 30 ? -11.244 -2.927  30.944 1.00 11.60 ? 30  ILE B C     1 
ATOM   713  O O     . ILE B 1 30 ? -10.834 -2.815  29.782 1.00 13.68 ? 30  ILE B O     1 
ATOM   714  C CB    . ILE B 1 30 ? -13.232 -1.415  31.336 1.00 15.07 ? 30  ILE B CB    1 
ATOM   715  C CG1   . ILE B 1 30 ? -13.760 -0.244  32.169 1.00 10.32 ? 30  ILE B CG1   1 
ATOM   716  C CG2   . ILE B 1 30 ? -14.111 -2.641  31.532 1.00 12.90 ? 30  ILE B CG2   1 
ATOM   717  C CD1   . ILE B 1 30 ? -13.590 -0.416  33.667 1.00 16.72 ? 30  ILE B CD1   1 
ATOM   718  N N     . LYS B 1 31 ? -11.261 -4.089  31.591 1.00 12.15 ? 31  LYS B N     1 
ATOM   719  C CA    . LYS B 1 31 ? -10.707 -5.319  31.035 1.00 17.32 ? 31  LYS B CA    1 
ATOM   720  C C     . LYS B 1 31 ? -11.853 -6.269  30.710 1.00 17.81 ? 31  LYS B C     1 
ATOM   721  O O     . LYS B 1 31 ? -12.453 -6.861  31.613 1.00 12.24 ? 31  LYS B O     1 
ATOM   722  C CB    . LYS B 1 31 ? -9.720  -5.952  32.016 1.00 21.01 ? 31  LYS B CB    1 
ATOM   723  C CG    . LYS B 1 31 ? -9.201  -7.331  31.621 1.00 12.59 ? 31  LYS B CG    1 
ATOM   724  C CD    . LYS B 1 31 ? -8.405  -7.945  32.769 1.00 17.54 ? 31  LYS B CD    1 
ATOM   725  C CE    . LYS B 1 31 ? -7.897  -9.337  32.435 1.00 30.02 ? 31  LYS B CE    1 
ATOM   726  N NZ    . LYS B 1 31 ? -6.608  -9.636  33.124 1.00 30.47 ? 31  LYS B NZ    1 
ATOM   727  N N     . LEU B 1 32 ? -12.155 -6.406  29.423 1.00 20.22 ? 32  LEU B N     1 
ATOM   728  C CA    . LEU B 1 32 ? -13.140 -7.365  28.950 1.00 19.42 ? 32  LEU B CA    1 
ATOM   729  C C     . LEU B 1 32 ? -12.449 -8.671  28.579 1.00 27.24 ? 32  LEU B C     1 
ATOM   730  O O     . LEU B 1 32 ? -11.322 -8.678  28.078 1.00 14.71 ? 32  LEU B O     1 
ATOM   731  C CB    . LEU B 1 32 ? -13.895 -6.810  27.744 1.00 20.44 ? 32  LEU B CB    1 
ATOM   732  C CG    . LEU B 1 32 ? -14.652 -5.501  27.971 1.00 22.09 ? 32  LEU B CG    1 
ATOM   733  C CD1   . LEU B 1 32 ? -15.293 -5.037  26.673 1.00 8.91  ? 32  LEU B CD1   1 
ATOM   734  C CD2   . LEU B 1 32 ? -15.702 -5.660  29.060 1.00 11.81 ? 32  LEU B CD2   1 
ATOM   735  N N     . GLN B 1 33 ? -13.138 -9.783  28.832 1.00 29.23 ? 33  GLN B N     1 
ATOM   736  C CA    . GLN B 1 33 ? -12.561 -11.106 28.634 1.00 28.83 ? 33  GLN B CA    1 
ATOM   737  C C     . GLN B 1 33 ? -13.572 -12.008 27.948 1.00 15.53 ? 33  GLN B C     1 
ATOM   738  O O     . GLN B 1 33 ? -14.744 -12.038 28.334 1.00 27.04 ? 33  GLN B O     1 
ATOM   739  C CB    . GLN B 1 33 ? -12.128 -11.720 29.970 1.00 25.03 ? 33  GLN B CB    1 
ATOM   740  C CG    . GLN B 1 33 ? -10.676 -11.465 30.334 1.00 21.07 ? 33  GLN B CG    1 
ATOM   741  C CD    . GLN B 1 33 ? -10.342 -11.927 31.737 1.00 23.41 ? 33  GLN B CD    1 
ATOM   742  O OE1   . GLN B 1 33 ? -9.424  -12.720 31.941 1.00 51.52 ? 33  GLN B OE1   1 
ATOM   743  N NE2   . GLN B 1 33 ? -11.087 -11.427 32.716 1.00 13.37 ? 33  GLN B NE2   1 
ATOM   744  N N     . GLY B 1 34 ? -13.113 -12.740 26.938 1.00 24.48 ? 34  GLY B N     1 
ATOM   745  C CA    . GLY B 1 34 ? -13.971 -13.649 26.206 1.00 30.49 ? 34  GLY B CA    1 
ATOM   746  C C     . GLY B 1 34 ? -13.248 -14.335 25.068 1.00 18.88 ? 34  GLY B C     1 
ATOM   747  O O     . GLY B 1 34 ? -12.058 -14.646 25.177 1.00 16.06 ? 34  GLY B O     1 
ATOM   748  N N     . GLN B 1 35 ? -13.958 -14.573 23.967 1.00 26.29 ? 35  GLN B N     1 
ATOM   749  C CA    . GLN B 1 35 ? -13.396 -15.233 22.798 1.00 17.24 ? 35  GLN B CA    1 
ATOM   750  C C     . GLN B 1 35 ? -13.701 -14.404 21.561 1.00 16.98 ? 35  GLN B C     1 
ATOM   751  O O     . GLN B 1 35 ? -14.844 -13.985 21.355 1.00 19.51 ? 35  GLN B O     1 
ATOM   752  C CB    . GLN B 1 35 ? -13.961 -16.648 22.628 1.00 22.32 ? 35  GLN B CB    1 
ATOM   753  C CG    . GLN B 1 35 ? -13.798 -17.543 23.844 1.00 19.81 ? 35  GLN B CG    1 
ATOM   754  C CD    . GLN B 1 35 ? -12.431 -18.191 23.909 1.00 23.19 ? 35  GLN B CD    1 
ATOM   755  O OE1   . GLN B 1 35 ? -11.721 -18.271 22.907 1.00 15.66 ? 35  GLN B OE1   1 
ATOM   756  N NE2   . GLN B 1 35 ? -12.057 -18.666 25.092 1.00 10.14 ? 35  GLN B NE2   1 
ATOM   757  N N     . ILE B 1 36 ? -12.677 -14.171 20.745 1.00 16.81 ? 36  ILE B N     1 
ATOM   758  C CA    . ILE B 1 36 ? -12.855 -13.500 19.463 1.00 20.10 ? 36  ILE B CA    1 
ATOM   759  C C     . ILE B 1 36 ? -13.625 -14.439 18.548 1.00 28.51 ? 36  ILE B C     1 
ATOM   760  O O     . ILE B 1 36 ? -13.068 -15.420 18.044 1.00 15.89 ? 36  ILE B O     1 
ATOM   761  C CB    . ILE B 1 36 ? -11.507 -13.100 18.833 1.00 16.22 ? 36  ILE B CB    1 
ATOM   762  C CG1   . ILE B 1 36 ? -10.639 -12.349 19.846 1.00 16.86 ? 36  ILE B CG1   1 
ATOM   763  C CG2   . ILE B 1 36 ? -11.732 -12.272 17.575 1.00 29.75 ? 36  ILE B CG2   1 
ATOM   764  C CD1   . ILE B 1 36 ? -10.993 -10.883 19.999 1.00 22.43 ? 36  ILE B CD1   1 
ATOM   765  N N     . GLU B 1 37 ? -14.911 -14.161 18.336 1.00 18.92 ? 37  GLU B N     1 
ATOM   766  C CA    . GLU B 1 37 ? -15.709 -14.974 17.429 1.00 11.16 ? 37  GLU B CA    1 
ATOM   767  C C     . GLU B 1 37 ? -15.695 -14.450 16.002 1.00 17.01 ? 37  GLU B C     1 
ATOM   768  O O     . GLU B 1 37 ? -15.942 -15.223 15.070 1.00 15.13 ? 37  GLU B O     1 
ATOM   769  C CB    . GLU B 1 37 ? -17.162 -15.058 17.911 1.00 17.99 ? 37  GLU B CB    1 
ATOM   770  C CG    . GLU B 1 37 ? -17.899 -13.728 17.938 1.00 31.48 ? 37  GLU B CG    1 
ATOM   771  C CD    . GLU B 1 37 ? -19.398 -13.879 17.726 1.00 48.54 ? 37  GLU B CD    1 
ATOM   772  O OE1   . GLU B 1 37 ? -19.845 -14.976 17.325 1.00 49.58 ? 37  GLU B OE1   1 
ATOM   773  O OE2   . GLU B 1 37 ? -20.132 -12.898 17.967 1.00 33.46 ? 37  GLU B OE2   1 
ATOM   774  N N     . SER B 1 38 ? -15.488 -13.147 15.869 1.00 25.15 ? 38  SER B N     1 
ATOM   775  C CA    . SER B 1 38 ? -15.557 -12.496 14.541 1.00 16.79 ? 38  SER B CA    1 
ATOM   776  C C     . SER B 1 38 ? -15.123 -11.034 14.673 1.00 16.89 ? 38  SER B C     1 
ATOM   777  O O     . SER B 1 38 ? -14.959 -10.583 15.802 1.00 9.20  ? 38  SER B O     1 
ATOM   778  C CB    . SER B 1 38 ? -16.932 -12.601 13.996 1.00 21.91 ? 38  SER B CB    1 
ATOM   779  O OG    . SER B 1 38 ? -17.893 -12.187 14.950 1.00 33.98 ? 38  SER B OG    1 
ATOM   780  N N     . PHE B 1 39 ? -14.847 -10.377 13.551 1.00 15.96 ? 39  PHE B N     1 
ATOM   781  C CA    . PHE B 1 39 ? -14.502 -8.937  13.548 1.00 18.79 ? 39  PHE B CA    1 
ATOM   782  C C     . PHE B 1 39 ? -14.575 -8.413  12.122 1.00 31.13 ? 39  PHE B C     1 
ATOM   783  O O     . PHE B 1 39 ? -14.688 -9.217  11.172 1.00 15.62 ? 39  PHE B O     1 
ATOM   784  C CB    . PHE B 1 39 ? -13.125 -8.646  14.141 1.00 28.33 ? 39  PHE B CB    1 
ATOM   785  C CG    . PHE B 1 39 ? -12.002 -9.473  13.535 1.00 22.76 ? 39  PHE B CG    1 
ATOM   786  C CD1   . PHE B 1 39 ? -11.732 -10.757 13.990 1.00 27.98 ? 39  PHE B CD1   1 
ATOM   787  C CD2   . PHE B 1 39 ? -11.220 -8.959  12.512 1.00 31.78 ? 39  PHE B CD2   1 
ATOM   788  C CE1   . PHE B 1 39 ? -10.709 -11.504 13.433 1.00 28.18 ? 39  PHE B CE1   1 
ATOM   789  C CE2   . PHE B 1 39 ? -10.192 -9.707  11.969 1.00 41.69 ? 39  PHE B CE2   1 
ATOM   790  C CZ    . PHE B 1 39 ? -9.943  -10.976 12.424 1.00 29.52 ? 39  PHE B CZ    1 
ATOM   791  N N     . ASP B 1 40 ? -14.534 -7.093  11.990 1.00 15.11 ? 40  ASP B N     1 
ATOM   792  C CA    . ASP B 1 40 ? -14.570 -6.422  10.673 1.00 20.67 ? 40  ASP B CA    1 
ATOM   793  C C     . ASP B 1 40 ? -13.660 -5.196  10.817 1.00 29.53 ? 40  ASP B C     1 
ATOM   794  O O     . ASP B 1 40 ? -12.916 -5.149  11.790 1.00 15.87 ? 40  ASP B O     1 
ATOM   795  C CB    . ASP B 1 40 ? -16.000 -6.138  10.253 1.00 25.22 ? 40  ASP B CB    1 
ATOM   796  C CG    . ASP B 1 40 ? -16.658 -4.975  10.968 1.00 26.90 ? 40  ASP B CG    1 
ATOM   797  O OD1   . ASP B 1 40 ? -16.244 -4.678  12.098 1.00 40.91 ? 40  ASP B OD1   1 
ATOM   798  O OD2   . ASP B 1 40 ? -17.558 -4.368  10.374 1.00 38.18 ? 40  ASP B OD2   1 
ATOM   799  N N     . GLN B 1 41 ? -13.736 -4.253  9.894  1.00 26.13 ? 41  GLN B N     1 
ATOM   800  C CA    . GLN B 1 41 ? -12.859 -3.060  9.902  1.00 38.55 ? 41  GLN B CA    1 
ATOM   801  C C     . GLN B 1 41 ? -13.044 -2.234  11.179 1.00 24.71 ? 41  GLN B C     1 
ATOM   802  O O     . GLN B 1 41 ? -12.073 -1.608  11.575 1.00 18.67 ? 41  GLN B O     1 
ATOM   803  C CB    . GLN B 1 41 ? -13.181 -2.181  8.695  1.00 34.92 ? 41  GLN B CB    1 
ATOM   804  C CG    . GLN B 1 41 ? -12.563 -0.790  8.766  1.00 68.32 ? 41  GLN B CG    1 
ATOM   805  C CD    . GLN B 1 41 ? -12.596 -0.055  7.447  1.00 68.67 ? 41  GLN B CD    1 
ATOM   806  O OE1   . GLN B 1 41 ? -13.402 -0.354  6.561  1.00 51.03 ? 41  GLN B OE1   1 
ATOM   807  N NE2   . GLN B 1 41 ? -11.711 0.921   7.310  1.00 45.94 ? 41  GLN B NE2   1 
ATOM   808  N N     . PHE B 1 42 ? -14.246 -2.190  11.742 1.00 18.77 ? 42  PHE B N     1 
ATOM   809  C CA    . PHE B 1 42 ? -14.535 -1.256  12.859 1.00 14.16 ? 42  PHE B CA    1 
ATOM   810  C C     . PHE B 1 42 ? -14.830 -1.896  14.188 1.00 12.39 ? 42  PHE B C     1 
ATOM   811  O O     . PHE B 1 42 ? -14.802 -1.136  15.134 1.00 13.49 ? 42  PHE B O     1 
ATOM   812  C CB    . PHE B 1 42 ? -15.741 -0.436  12.394 1.00 25.44 ? 42  PHE B CB    1 
ATOM   813  C CG    . PHE B 1 42 ? -15.500 0.348   11.116 1.00 17.51 ? 42  PHE B CG    1 
ATOM   814  C CD1   . PHE B 1 42 ? -14.749 1.516   11.130 1.00 16.91 ? 42  PHE B CD1   1 
ATOM   815  C CD2   . PHE B 1 42 ? -16.011 -0.096  9.904  1.00 27.10 ? 42  PHE B CD2   1 
ATOM   816  C CE1   . PHE B 1 42 ? -14.526 2.223   9.962  1.00 23.76 ? 42  PHE B CE1   1 
ATOM   817  C CE2   . PHE B 1 42 ? -15.780 0.615   8.739  1.00 31.56 ? 42  PHE B CE2   1 
ATOM   818  C CZ    . PHE B 1 42 ? -15.040 1.771   8.770  1.00 22.76 ? 42  PHE B CZ    1 
ATOM   819  N N     . VAL B 1 43 ? -15.141 -3.184  14.273 1.00 11.15 ? 43  VAL B N     1 
ATOM   820  C CA    . VAL B 1 43 ? -15.571 -3.768  15.573 1.00 13.86 ? 43  VAL B CA    1 
ATOM   821  C C     . VAL B 1 43 ? -15.081 -5.217  15.734 1.00 18.65 ? 43  VAL B C     1 
ATOM   822  O O     . VAL B 1 43 ? -14.752 -5.840  14.725 1.00 7.84  ? 43  VAL B O     1 
ATOM   823  C CB    . VAL B 1 43 ? -17.105 -3.712  15.780 1.00 23.58 ? 43  VAL B CB    1 
ATOM   824  C CG1   . VAL B 1 43 ? -17.727 -2.367  15.416 1.00 10.68 ? 43  VAL B CG1   1 
ATOM   825  C CG2   . VAL B 1 43 ? -17.828 -4.873  15.110 1.00 14.04 ? 43  VAL B CG2   1 
ATOM   826  N N     . ILE B 1 44 ? -15.053 -5.687  16.986 1.00 14.84 ? 44  ILE B N     1 
ATOM   827  C CA    . ILE B 1 44 ? -14.663 -7.085  17.319 1.00 18.09 ? 44  ILE B CA    1 
ATOM   828  C C     . ILE B 1 44 ? -15.781 -7.701  18.169 1.00 22.75 ? 44  ILE B C     1 
ATOM   829  O O     . ILE B 1 44 ? -16.052 -7.190  19.265 1.00 16.81 ? 44  ILE B O     1 
ATOM   830  C CB    . ILE B 1 44 ? -13.306 -7.149  18.027 1.00 20.22 ? 44  ILE B CB    1 
ATOM   831  C CG1   . ILE B 1 44 ? -12.161 -6.810  17.073 1.00 17.16 ? 44  ILE B CG1   1 
ATOM   832  C CG2   . ILE B 1 44 ? -13.110 -8.515  18.679 1.00 28.26 ? 44  ILE B CG2   1 
ATOM   833  C CD1   . ILE B 1 44 ? -11.001 -6.092  17.733 1.00 24.71 ? 44  ILE B CD1   1 
ATOM   834  N N     . LEU B 1 45 ? -16.398 -8.765  17.680 1.00 20.18 ? 45  LEU B N     1 
ATOM   835  C CA    . LEU B 1 45 ? -17.429 -9.472  18.428 1.00 12.86 ? 45  LEU B CA    1 
ATOM   836  C C     . LEU B 1 45 ? -16.767 -10.414 19.430 1.00 19.39 ? 45  LEU B C     1 
ATOM   837  O O     . LEU B 1 45 ? -16.049 -11.340 19.037 1.00 27.91 ? 45  LEU B O     1 
ATOM   838  C CB    . LEU B 1 45 ? -18.342 -10.241 17.476 1.00 15.19 ? 45  LEU B CB    1 
ATOM   839  C CG    . LEU B 1 45 ? -19.688 -9.601  17.124 1.00 27.72 ? 45  LEU B CG    1 
ATOM   840  C CD1   . LEU B 1 45 ? -20.698 -9.831  18.236 1.00 22.69 ? 45  LEU B CD1   1 
ATOM   841  C CD2   . LEU B 1 45 ? -19.528 -8.113  16.840 1.00 29.85 ? 45  LEU B CD2   1 
ATOM   842  N N     . LEU B 1 46 ? -17.006 -10.173 20.717 1.00 17.87 ? 46  LEU B N     1 
ATOM   843  C CA    . LEU B 1 46 ? -16.474 -10.986 21.800 1.00 17.70 ? 46  LEU B CA    1 
ATOM   844  C C     . LEU B 1 46 ? -17.592 -11.836 22.387 1.00 23.83 ? 46  LEU B C     1 
ATOM   845  O O     . LEU B 1 46 ? -18.770 -11.471 22.318 1.00 29.49 ? 46  LEU B O     1 
ATOM   846  C CB    . LEU B 1 46 ? -15.857 -10.105 22.889 1.00 16.62 ? 46  LEU B CB    1 
ATOM   847  C CG    . LEU B 1 46 ? -15.217 -10.777 24.105 1.00 25.97 ? 46  LEU B CG    1 
ATOM   848  C CD1   . LEU B 1 46 ? -13.776 -11.165 23.811 1.00 18.84 ? 46  LEU B CD1   1 
ATOM   849  C CD2   . LEU B 1 46 ? -15.300 -9.853  25.310 1.00 9.57  ? 46  LEU B CD2   1 
ATOM   850  N N     . LYS B 1 47 ? -17.219 -12.971 22.975 1.00 26.66 ? 47  LYS B N     1 
ATOM   851  C CA    . LYS B 1 47 ? -18.189 -13.916 23.503 1.00 25.31 ? 47  LYS B CA    1 
ATOM   852  C C     . LYS B 1 47 ? -17.836 -14.322 24.926 1.00 16.33 ? 47  LYS B C     1 
ATOM   853  O O     . LYS B 1 47 ? -16.663 -14.431 25.293 1.00 28.60 ? 47  LYS B O     1 
ATOM   854  C CB    . LYS B 1 47 ? -18.276 -15.180 22.630 1.00 28.48 ? 47  LYS B CB    1 
ATOM   855  C CG    . LYS B 1 47 ? -18.573 -14.929 21.158 1.00 40.57 ? 47  LYS B CG    1 
ATOM   856  C CD    . LYS B 1 47 ? -19.905 -15.558 20.742 1.00 42.84 ? 47  LYS B CD    1 
ATOM   857  C CE    . LYS B 1 47 ? -19.897 -17.076 20.907 1.00 49.47 ? 47  LYS B CE    1 
ATOM   858  N NZ    . LYS B 1 47 ? -21.219 -17.685 20.578 1.00 44.66 ? 47  LYS B NZ    1 
ATOM   859  N N     . ASN B 1 48 ? -18.878 -14.543 25.724 1.00 29.93 ? 48  ASN B N     1 
ATOM   860  C CA    . ASN B 1 48 ? -18.754 -15.186 27.025 1.00 31.37 ? 48  ASN B CA    1 
ATOM   861  C C     . ASN B 1 48 ? -20.123 -15.740 27.413 1.00 48.77 ? 48  ASN B C     1 
ATOM   862  O O     . ASN B 1 48 ? -20.411 -16.916 27.169 1.00 44.19 ? 48  ASN B O     1 
ATOM   863  C CB    . ASN B 1 48 ? -18.220 -14.211 28.073 1.00 44.96 ? 48  ASN B CB    1 
ATOM   864  C CG    . ASN B 1 48 ? -17.541 -14.917 29.240 1.00 53.63 ? 48  ASN B CG    1 
ATOM   865  O OD1   . ASN B 1 48 ? -16.622 -14.376 29.855 1.00 45.45 ? 48  ASN B OD1   1 
ATOM   866  N ND2   . ASN B 1 48 ? -17.996 -16.129 29.551 1.00 46.00 ? 48  ASN B ND2   1 
ATOM   867  N N     . THR B 1 49 ? -20.975 -14.908 28.016 1.00 43.89 ? 49  THR B N     1 
ATOM   868  C CA    . THR B 1 49 ? -22.377 -15.260 28.213 1.00 51.93 ? 49  THR B CA    1 
ATOM   869  C C     . THR B 1 49 ? -23.206 -14.912 26.979 1.00 52.93 ? 49  THR B C     1 
ATOM   870  O O     . THR B 1 49 ? -23.965 -15.746 26.476 1.00 40.40 ? 49  THR B O     1 
ATOM   871  C CB    . THR B 1 49 ? -22.940 -14.544 29.446 1.00 46.32 ? 49  THR B CB    1 
ATOM   872  O OG1   . THR B 1 49 ? -21.922 -14.436 30.448 1.00 66.20 ? 49  THR B OG1   1 
ATOM   873  C CG2   . THR B 1 49 ? -24.128 -15.308 30.010 1.00 38.76 ? 49  THR B CG2   1 
ATOM   874  N N     . VAL B 1 50 ? -23.058 -13.685 26.481 1.00 45.85 ? 50  VAL B N     1 
ATOM   875  C CA    . VAL B 1 50 ? -23.703 -13.253 25.247 1.00 39.67 ? 50  VAL B CA    1 
ATOM   876  C C     . VAL B 1 50 ? -22.624 -12.778 24.282 1.00 29.98 ? 50  VAL B C     1 
ATOM   877  O O     . VAL B 1 50 ? -21.437 -12.745 24.628 1.00 11.52 ? 50  VAL B O     1 
ATOM   878  C CB    . VAL B 1 50 ? -24.735 -12.141 25.509 1.00 42.93 ? 50  VAL B CB    1 
ATOM   879  C CG1   . VAL B 1 50 ? -25.833 -12.642 26.435 1.00 32.13 ? 50  VAL B CG1   1 
ATOM   880  C CG2   . VAL B 1 50 ? -24.056 -10.907 26.091 1.00 13.90 ? 50  VAL B CG2   1 
ATOM   881  N N     . SER B 1 51 ? -23.027 -12.404 23.069 1.00 42.84 ? 51  SER B N     1 
ATOM   882  C CA    . SER B 1 51 ? -22.119 -11.852 22.069 1.00 38.90 ? 51  SER B CA    1 
ATOM   883  C C     . SER B 1 51 ? -22.245 -10.333 22.099 1.00 24.58 ? 51  SER B C     1 
ATOM   884  O O     . SER B 1 51 ? -23.263 -9.781  21.667 1.00 23.77 ? 51  SER B O     1 
ATOM   885  C CB    . SER B 1 51 ? -22.438 -12.394 20.677 1.00 33.00 ? 51  SER B CB    1 
ATOM   886  O OG    . SER B 1 51 ? -22.253 -13.794 20.616 1.00 48.71 ? 51  SER B OG    1 
ATOM   887  N N     . GLN B 1 52 ? -21.217 -9.661  22.608 1.00 17.92 ? 52  GLN B N     1 
ATOM   888  C CA    . GLN B 1 52 ? -21.192 -8.207  22.677 1.00 14.67 ? 52  GLN B CA    1 
ATOM   889  C C     . GLN B 1 52 ? -20.302 -7.643  21.578 1.00 13.37 ? 52  GLN B C     1 
ATOM   890  O O     . GLN B 1 52 ? -19.274 -8.230  21.230 1.00 19.19 ? 52  GLN B O     1 
ATOM   891  C CB    . GLN B 1 52 ? -20.696 -7.731  24.045 1.00 29.32 ? 52  GLN B CB    1 
ATOM   892  C CG    . GLN B 1 52 ? -19.212 -7.950  24.278 1.00 20.98 ? 52  GLN B CG    1 
ATOM   893  C CD    . GLN B 1 52 ? -18.788 -7.611  25.693 1.00 15.41 ? 52  GLN B CD    1 
ATOM   894  O OE1   . GLN B 1 52 ? -18.518 -6.455  26.012 1.00 22.13 ? 52  GLN B OE1   1 
ATOM   895  N NE2   . GLN B 1 52 ? -18.736 -8.620  26.553 1.00 17.01 ? 52  GLN B NE2   1 
ATOM   896  N N     . MET B 1 53 ? -20.704 -6.497  21.037 1.00 19.59 ? 53  MET B N     1 
ATOM   897  C CA    . MET B 1 53 ? -19.977 -5.837  19.961 1.00 12.96 ? 53  MET B CA    1 
ATOM   898  C C     . MET B 1 53 ? -19.083 -4.757  20.555 1.00 17.24 ? 53  MET B C     1 
ATOM   899  O O     . MET B 1 53 ? -19.568 -3.853  21.244 1.00 19.46 ? 53  MET B O     1 
ATOM   900  C CB    . MET B 1 53 ? -20.946 -5.233  18.945 1.00 23.40 ? 53  MET B CB    1 
ATOM   901  C CG    . MET B 1 53 ? -20.276 -4.697  17.693 1.00 16.50 ? 53  MET B CG    1 
ATOM   902  S SD    . MET B 1 53 ? -21.463 -3.921  16.584 1.00 15.94 ? 53  MET B SD    1 
ATOM   903  C CE    . MET B 1 53 ? -21.577 -2.280  17.294 1.00 21.96 ? 53  MET B CE    1 
ATOM   904  N N     . VAL B 1 54 ? -17.785 -4.849  20.279 1.00 23.31 ? 54  VAL B N     1 
ATOM   905  C CA    . VAL B 1 54 ? -16.791 -3.929  20.820 1.00 27.64 ? 54  VAL B CA    1 
ATOM   906  C C     . VAL B 1 54 ? -16.215 -3.116  19.670 1.00 24.34 ? 54  VAL B C     1 
ATOM   907  O O     . VAL B 1 54 ? -15.649 -3.678  18.723 1.00 14.00 ? 54  VAL B O     1 
ATOM   908  C CB    . VAL B 1 54 ? -15.681 -4.675  21.575 1.00 12.96 ? 54  VAL B CB    1 
ATOM   909  C CG1   . VAL B 1 54 ? -14.830 -3.695  22.372 1.00 7.26  ? 54  VAL B CG1   1 
ATOM   910  C CG2   . VAL B 1 54 ? -16.279 -5.737  22.484 1.00 7.41  ? 54  VAL B CG2   1 
ATOM   911  N N     . TYR B 1 55 ? -16.357 -1.796  19.752 1.00 8.78  ? 55  TYR B N     1 
ATOM   912  C CA    . TYR B 1 55 ? -15.753 -0.917  18.761 1.00 19.33 ? 55  TYR B CA    1 
ATOM   913  C C     . TYR B 1 55 ? -14.240 -0.897  18.934 1.00 14.55 ? 55  TYR B C     1 
ATOM   914  O O     . TYR B 1 55 ? -13.733 -0.764  20.052 1.00 4.24  ? 55  TYR B O     1 
ATOM   915  C CB    . TYR B 1 55 ? -16.314 0.497   18.890 1.00 17.61 ? 55  TYR B CB    1 
ATOM   916  C CG    . TYR B 1 55 ? -17.758 0.613   18.476 1.00 18.81 ? 55  TYR B CG    1 
ATOM   917  C CD1   . TYR B 1 55 ? -18.780 0.307   19.362 1.00 10.51 ? 55  TYR B CD1   1 
ATOM   918  C CD2   . TYR B 1 55 ? -18.100 1.024   17.196 1.00 10.53 ? 55  TYR B CD2   1 
ATOM   919  C CE1   . TYR B 1 55 ? -20.103 0.409   18.986 1.00 25.58 ? 55  TYR B CE1   1 
ATOM   920  C CE2   . TYR B 1 55 ? -19.417 1.130   16.812 1.00 18.06 ? 55  TYR B CE2   1 
ATOM   921  C CZ    . TYR B 1 55 ? -20.416 0.822   17.711 1.00 10.78 ? 55  TYR B CZ    1 
ATOM   922  O OH    . TYR B 1 55 ? -21.733 0.924   17.331 1.00 5.01  ? 55  TYR B OH    1 
ATOM   923  N N     . LYS B 1 56 ? -13.517 -1.025  17.820 1.00 5.62  ? 56  LYS B N     1 
ATOM   924  C CA    . LYS B 1 56 ? -12.062 -1.009  17.889 1.00 9.64  ? 56  LYS B CA    1 
ATOM   925  C C     . LYS B 1 56 ? -11.532 0.353   18.321 1.00 5.81  ? 56  LYS B C     1 
ATOM   926  O O     . LYS B 1 56 ? -10.481 0.427   18.967 1.00 10.26 ? 56  LYS B O     1 
ATOM   927  C CB    . LYS B 1 56 ? -11.468 -1.404  16.537 1.00 15.32 ? 56  LYS B CB    1 
ATOM   928  C CG    . LYS B 1 56 ? -11.531 -2.895  16.233 1.00 7.71  ? 56  LYS B CG    1 
ATOM   929  C CD    . LYS B 1 56 ? -11.466 -3.149  14.732 1.00 24.68 ? 56  LYS B CD    1 
ATOM   930  C CE    . LYS B 1 56 ? -10.899 -4.523  14.413 1.00 32.83 ? 56  LYS B CE    1 
ATOM   931  N NZ    . LYS B 1 56 ? -10.328 -4.579  13.037 1.00 33.46 ? 56  LYS B NZ    1 
ATOM   932  N N     . HIS B 1 57 ? -12.241 1.438   17.990 1.00 20.71 ? 57  HIS B N     1 
ATOM   933  C CA    . HIS B 1 57 ? -11.766 2.769   18.353 1.00 12.02 ? 57  HIS B CA    1 
ATOM   934  C C     . HIS B 1 57 ? -11.712 2.979   19.860 1.00 11.21 ? 57  HIS B C     1 
ATOM   935  O O     . HIS B 1 57 ? -11.101 3.956   20.309 1.00 10.97 ? 57  HIS B O     1 
ATOM   936  C CB    . HIS B 1 57 ? -12.645 3.848   17.703 1.00 7.42  ? 57  HIS B CB    1 
ATOM   937  C CG    . HIS B 1 57 ? -14.073 3.837   18.158 1.00 12.62 ? 57  HIS B CG    1 
ATOM   938  N ND1   . HIS B 1 57 ? -15.127 3.703   17.280 1.00 9.31  ? 57  HIS B ND1   1 
ATOM   939  C CD2   . HIS B 1 57 ? -14.624 3.984   19.386 1.00 8.25  ? 57  HIS B CD2   1 
ATOM   940  C CE1   . HIS B 1 57 ? -16.264 3.743   17.951 1.00 10.07 ? 57  HIS B CE1   1 
ATOM   941  N NE2   . HIS B 1 57 ? -15.987 3.911   19.231 1.00 15.13 ? 57  HIS B NE2   1 
ATOM   942  N N     . ALA B 1 58 ? -12.321 2.092   20.645 1.00 12.31 ? 58  ALA B N     1 
ATOM   943  C CA    . ALA B 1 58 ? -12.311 2.190   22.098 1.00 5.91  ? 58  ALA B CA    1 
ATOM   944  C C     . ALA B 1 58 ? -11.466 1.112   22.764 1.00 6.49  ? 58  ALA B C     1 
ATOM   945  O O     . ALA B 1 58 ? -11.415 1.060   23.999 1.00 3.48  ? 58  ALA B O     1 
ATOM   946  C CB    . ALA B 1 58 ? -13.747 2.129   22.633 1.00 11.64 ? 58  ALA B CB    1 
ATOM   947  N N     . ILE B 1 59 ? -10.801 0.261   21.990 1.00 5.40  ? 59  ILE B N     1 
ATOM   948  C CA    . ILE B 1 59 ? -9.952  -0.792  22.536 1.00 12.30 ? 59  ILE B CA    1 
ATOM   949  C C     . ILE B 1 59 ? -8.533  -0.260  22.659 1.00 8.40  ? 59  ILE B C     1 
ATOM   950  O O     . ILE B 1 59 ? -7.977  0.287   21.699 1.00 4.15  ? 59  ILE B O     1 
ATOM   951  C CB    . ILE B 1 59 ? -9.993  -2.050  21.652 1.00 16.16 ? 59  ILE B CB    1 
ATOM   952  C CG1   . ILE B 1 59 ? -11.367 -2.719  21.745 1.00 9.62  ? 59  ILE B CG1   1 
ATOM   953  C CG2   . ILE B 1 59 ? -8.882  -3.009  22.046 1.00 13.71 ? 59  ILE B CG2   1 
ATOM   954  C CD1   . ILE B 1 59 ? -11.585 -3.818  20.724 1.00 10.59 ? 59  ILE B CD1   1 
ATOM   955  N N     . SER B 1 60 ? -7.944  -0.413  23.839 1.00 8.85  ? 60  SER B N     1 
ATOM   956  C CA    . SER B 1 60 ? -6.562  0.002   24.029 1.00 12.15 ? 60  SER B CA    1 
ATOM   957  C C     . SER B 1 60 ? -5.562  -1.123  23.823 1.00 8.73  ? 60  SER B C     1 
ATOM   958  O O     . SER B 1 60 ? -4.431  -0.861  23.394 1.00 20.12 ? 60  SER B O     1 
ATOM   959  C CB    . SER B 1 60 ? -6.366  0.569   25.434 1.00 8.89  ? 60  SER B CB    1 
ATOM   960  O OG    . SER B 1 60 ? -5.840  -0.398  26.338 1.00 12.48 ? 60  SER B OG    1 
ATOM   961  N N     . THR B 1 61 ? -5.949  -2.364  24.107 1.00 8.21  ? 61  THR B N     1 
ATOM   962  C CA    . THR B 1 61 ? -5.041  -3.492  23.956 1.00 22.33 ? 61  THR B CA    1 
ATOM   963  C C     . THR B 1 61 ? -5.848  -4.777  23.813 1.00 16.06 ? 61  THR B C     1 
ATOM   964  O O     . THR B 1 61 ? -6.969  -4.888  24.319 1.00 10.58 ? 61  THR B O     1 
ATOM   965  C CB    . THR B 1 61 ? -4.073  -3.602  25.145 1.00 14.44 ? 61  THR B CB    1 
ATOM   966  O OG1   . THR B 1 61 ? -3.030  -2.626  25.013 1.00 22.75 ? 61  THR B OG1   1 
ATOM   967  C CG2   . THR B 1 61 ? -3.429  -4.985  25.205 1.00 38.02 ? 61  THR B CG2   1 
ATOM   968  N N     . VAL B 1 62 ? -5.257  -5.742  23.112 1.00 29.57 ? 62  VAL B N     1 
ATOM   969  C CA    . VAL B 1 62 ? -5.787  -7.098  22.999 1.00 26.78 ? 62  VAL B CA    1 
ATOM   970  C C     . VAL B 1 62 ? -4.680  -8.054  23.426 1.00 29.63 ? 62  VAL B C     1 
ATOM   971  O O     . VAL B 1 62 ? -3.659  -8.174  22.737 1.00 24.03 ? 62  VAL B O     1 
ATOM   972  C CB    . VAL B 1 62 ? -6.263  -7.422  21.575 1.00 24.38 ? 62  VAL B CB    1 
ATOM   973  C CG1   . VAL B 1 62 ? -6.628  -8.899  21.456 1.00 27.75 ? 62  VAL B CG1   1 
ATOM   974  C CG2   . VAL B 1 62 ? -7.443  -6.542  21.192 1.00 38.25 ? 62  VAL B CG2   1 
ATOM   975  N N     . VAL B 1 63 ? -4.887  -8.754  24.535 1.00 30.99 ? 63  VAL B N     1 
ATOM   976  C CA    . VAL B 1 63 ? -3.882  -9.634  25.124 1.00 37.00 ? 63  VAL B CA    1 
ATOM   977  C C     . VAL B 1 63 ? -4.374  -11.073 25.017 1.00 27.57 ? 63  VAL B C     1 
ATOM   978  O O     . VAL B 1 63 ? -5.400  -11.415 25.622 1.00 14.84 ? 63  VAL B O     1 
ATOM   979  C CB    . VAL B 1 63 ? -3.596  -9.267  26.589 1.00 23.65 ? 63  VAL B CB    1 
ATOM   980  C CG1   . VAL B 1 63 ? -2.478  -10.137 27.146 1.00 23.61 ? 63  VAL B CG1   1 
ATOM   981  C CG2   . VAL B 1 63 ? -3.244  -7.796  26.716 1.00 25.30 ? 63  VAL B CG2   1 
ATOM   982  N N     . PRO B 1 64 ? -3.687  -11.948 24.282 1.00 33.62 ? 64  PRO B N     1 
ATOM   983  C CA    . PRO B 1 64 ? -4.000  -13.380 24.376 1.00 30.11 ? 64  PRO B CA    1 
ATOM   984  C C     . PRO B 1 64 ? -3.635  -13.920 25.750 1.00 15.60 ? 64  PRO B C     1 
ATOM   985  O O     . PRO B 1 64 ? -2.619  -13.540 26.335 1.00 18.03 ? 64  PRO B O     1 
ATOM   986  C CB    . PRO B 1 64 ? -3.141  -14.010 23.273 1.00 14.46 ? 64  PRO B CB    1 
ATOM   987  C CG    . PRO B 1 64 ? -2.010  -13.053 23.089 1.00 29.68 ? 64  PRO B CG    1 
ATOM   988  C CD    . PRO B 1 64 ? -2.600  -11.684 23.320 1.00 35.71 ? 64  PRO B CD    1 
ATOM   989  N N     . SER B 1 65 ? -4.484  -14.810 26.270 1.00 14.06 ? 65  SER B N     1 
ATOM   990  C CA    . SER B 1 65 ? -4.238  -15.379 27.590 1.00 21.82 ? 65  SER B CA    1 
ATOM   991  C C     . SER B 1 65 ? -3.016  -16.285 27.609 1.00 19.42 ? 65  SER B C     1 
ATOM   992  O O     . SER B 1 65 ? -2.520  -16.616 28.692 1.00 15.37 ? 65  SER B O     1 
ATOM   993  C CB    . SER B 1 65 ? -5.460  -16.166 28.063 1.00 29.70 ? 65  SER B CB    1 
ATOM   994  O OG    . SER B 1 65 ? -5.669  -17.303 27.244 1.00 17.60 ? 65  SER B OG    1 
ATOM   995  N N     . ARG B 1 66 ? -2.524  -16.693 26.443 1.00 26.69 ? 66  ARG B N     1 
ATOM   996  C CA    . ARG B 1 66 ? -1.385  -17.594 26.352 1.00 26.63 ? 66  ARG B CA    1 
ATOM   997  C C     . ARG B 1 66 ? -0.764  -17.449 24.971 1.00 42.63 ? 66  ARG B C     1 
ATOM   998  O O     . ARG B 1 66 ? -1.442  -17.039 24.021 1.00 36.47 ? 66  ARG B O     1 
ATOM   999  C CB    . ARG B 1 66 ? -1.801  -19.050 26.605 1.00 38.37 ? 66  ARG B CB    1 
ATOM   1000 C CG    . ARG B 1 66 ? -2.914  -19.578 25.704 1.00 36.51 ? 66  ARG B CG    1 
ATOM   1001 C CD    . ARG B 1 66 ? -3.509  -20.842 26.311 1.00 35.83 ? 66  ARG B CD    1 
ATOM   1002 N NE    . ARG B 1 66 ? -4.967  -20.890 26.315 1.00 42.71 ? 66  ARG B NE    1 
ATOM   1003 C CZ    . ARG B 1 66 ? -5.698  -21.523 25.406 1.00 47.59 ? 66  ARG B CZ    1 
ATOM   1004 N NH1   . ARG B 1 66 ? -5.154  -22.039 24.316 1.00 45.35 ? 66  ARG B NH1   1 
ATOM   1005 N NH2   . ARG B 1 66 ? -7.007  -21.650 25.600 1.00 43.90 ? 66  ARG B NH2   1 
ATOM   1006 N N     . PRO B 1 67 ? 0.517   -17.789 24.823 1.00 41.06 ? 67  PRO B N     1 
ATOM   1007 C CA    . PRO B 1 67 ? 1.182   -17.602 23.526 1.00 42.14 ? 67  PRO B CA    1 
ATOM   1008 C C     . PRO B 1 67 ? 0.576   -18.498 22.456 1.00 60.82 ? 67  PRO B C     1 
ATOM   1009 O O     . PRO B 1 67 ? 0.211   -19.647 22.715 1.00 75.03 ? 67  PRO B O     1 
ATOM   1010 C CB    . PRO B 1 67 ? 2.643   -17.976 23.815 1.00 57.74 ? 67  PRO B CB    1 
ATOM   1011 C CG    . PRO B 1 67 ? 2.774   -17.900 25.317 1.00 42.50 ? 67  PRO B CG    1 
ATOM   1012 C CD    . PRO B 1 67 ? 1.437   -18.340 25.833 1.00 47.58 ? 67  PRO B CD    1 
ATOM   1013 N N     . VAL B 1 68 ? 0.469   -17.958 21.244 1.00 52.25 ? 68  VAL B N     1 
ATOM   1014 C CA    . VAL B 1 68 ? -0.160  -18.652 20.125 1.00 74.26 ? 68  VAL B CA    1 
ATOM   1015 C C     . VAL B 1 68 ? 0.807   -18.649 18.949 1.00 73.45 ? 68  VAL B C     1 
ATOM   1016 O O     . VAL B 1 68 ? 1.026   -17.606 18.320 1.00 65.60 ? 68  VAL B O     1 
ATOM   1017 C CB    . VAL B 1 68 ? -1.498  -18.014 19.723 1.00 63.84 ? 68  VAL B CB    1 
ATOM   1018 C CG1   . VAL B 1 68 ? -1.364  -16.499 19.632 1.00 52.41 ? 68  VAL B CG1   1 
ATOM   1019 C CG2   . VAL B 1 68 ? -1.984  -18.589 18.398 1.00 68.85 ? 68  VAL B CG2   1 
ATOM   1020 N N     . SER C 1 6  ? 0.070   25.934  6.931  1.00 49.46 ? 6   SER C N     1 
ATOM   1021 C CA    . SER C 1 6  ? -0.850  25.633  8.023  1.00 33.93 ? 6   SER C CA    1 
ATOM   1022 C C     . SER C 1 6  ? -0.540  26.497  9.239  1.00 34.86 ? 6   SER C C     1 
ATOM   1023 O O     . SER C 1 6  ? 0.331   27.364  9.189  1.00 44.74 ? 6   SER C O     1 
ATOM   1024 C CB    . SER C 1 6  ? -0.770  24.155  8.402  1.00 45.65 ? 6   SER C CB    1 
ATOM   1025 O OG    . SER C 1 6  ? 0.429   23.877  9.105  1.00 36.93 ? 6   SER C OG    1 
ATOM   1026 N N     . LEU C 1 7  ? -1.256  26.252  10.334 1.00 27.21 ? 7   LEU C N     1 
ATOM   1027 C CA    . LEU C 1 7  ? -1.040  26.963  11.585 1.00 35.08 ? 7   LEU C CA    1 
ATOM   1028 C C     . LEU C 1 7  ? -0.292  26.130  12.615 1.00 33.11 ? 7   LEU C C     1 
ATOM   1029 O O     . LEU C 1 7  ? -0.110  26.588  13.747 1.00 47.77 ? 7   LEU C O     1 
ATOM   1030 C CB    . LEU C 1 7  ? -2.380  27.413  12.174 1.00 37.40 ? 7   LEU C CB    1 
ATOM   1031 C CG    . LEU C 1 7  ? -2.319  28.359  13.376 1.00 36.24 ? 7   LEU C CG    1 
ATOM   1032 C CD1   . LEU C 1 7  ? -1.457  29.585  13.080 1.00 35.01 ? 7   LEU C CD1   1 
ATOM   1033 C CD2   . LEU C 1 7  ? -3.722  28.776  13.800 1.00 32.85 ? 7   LEU C CD2   1 
ATOM   1034 N N     . GLN C 1 8  ? 0.144   24.925  12.260 1.00 28.16 ? 8   GLN C N     1 
ATOM   1035 C CA    . GLN C 1 8  ? 0.940   24.100  13.157 1.00 23.94 ? 8   GLN C CA    1 
ATOM   1036 C C     . GLN C 1 8  ? 2.283   23.696  12.573 1.00 25.33 ? 8   GLN C C     1 
ATOM   1037 O O     . GLN C 1 8  ? 3.234   23.505  13.333 1.00 16.72 ? 8   GLN C O     1 
ATOM   1038 C CB    . GLN C 1 8  ? 0.165   22.835  13.563 1.00 35.89 ? 8   GLN C CB    1 
ATOM   1039 C CG    . GLN C 1 8  ? -0.100  21.859  12.444 1.00 28.74 ? 8   GLN C CG    1 
ATOM   1040 C CD    . GLN C 1 8  ? -0.763  20.589  12.938 1.00 39.27 ? 8   GLN C CD    1 
ATOM   1041 O OE1   . GLN C 1 8  ? -0.110  19.703  13.492 1.00 26.32 ? 8   GLN C OE1   1 
ATOM   1042 N NE2   . GLN C 1 8  ? -2.072  20.500  12.749 1.00 33.05 ? 8   GLN C NE2   1 
ATOM   1043 N N     . ASP C 1 9  ? 2.395   23.573  11.250 1.00 30.20 ? 9   ASP C N     1 
ATOM   1044 C CA    . ASP C 1 9  ? 3.707   23.344  10.649 1.00 24.55 ? 9   ASP C CA    1 
ATOM   1045 C C     . ASP C 1 9  ? 4.671   24.473  10.974 1.00 33.01 ? 9   ASP C C     1 
ATOM   1046 O O     . ASP C 1 9  ? 5.793   24.190  11.432 1.00 30.59 ? 9   ASP C O     1 
ATOM   1047 C CB    . ASP C 1 9  ? 3.562   23.160  9.135  1.00 32.92 ? 9   ASP C CB    1 
ATOM   1048 C CG    . ASP C 1 9  ? 3.436   21.705  8.735  1.00 41.62 ? 9   ASP C CG    1 
ATOM   1049 O OD1   . ASP C 1 9  ? 4.103   21.299  7.760  1.00 38.27 ? 9   ASP C OD1   1 
ATOM   1050 O OD2   . ASP C 1 9  ? 2.673   20.969  9.395  1.00 42.20 ? 9   ASP C OD2   1 
ATOM   1051 N N     . PRO C 1 10 ? 4.322   25.747  10.775 1.00 20.51 ? 10  PRO C N     1 
ATOM   1052 C CA    . PRO C 1 10 ? 5.246   26.820  11.176 1.00 26.09 ? 10  PRO C CA    1 
ATOM   1053 C C     . PRO C 1 10 ? 5.339   26.996  12.682 1.00 20.14 ? 10  PRO C C     1 
ATOM   1054 O O     . PRO C 1 10 ? 6.396   27.403  13.180 1.00 17.27 ? 10  PRO C O     1 
ATOM   1055 C CB    . PRO C 1 10 ? 4.673   28.075  10.496 1.00 30.77 ? 10  PRO C CB    1 
ATOM   1056 C CG    . PRO C 1 10 ? 3.484   27.634  9.699  1.00 29.90 ? 10  PRO C CG    1 
ATOM   1057 C CD    . PRO C 1 10 ? 3.109   26.249  10.108 1.00 26.80 ? 10  PRO C CD    1 
ATOM   1058 N N     . PHE C 1 11 ? 4.270   26.701  13.427 1.00 26.63 ? 11  PHE C N     1 
ATOM   1059 C CA    . PHE C 1 11 ? 4.305   26.880  14.876 1.00 20.80 ? 11  PHE C CA    1 
ATOM   1060 C C     . PHE C 1 11 ? 5.329   25.951  15.513 1.00 18.77 ? 11  PHE C C     1 
ATOM   1061 O O     . PHE C 1 11 ? 6.198   26.392  16.274 1.00 16.03 ? 11  PHE C O     1 
ATOM   1062 C CB    . PHE C 1 11 ? 2.919   26.635  15.474 1.00 13.80 ? 11  PHE C CB    1 
ATOM   1063 C CG    . PHE C 1 11 ? 2.872   26.765  16.971 1.00 11.41 ? 11  PHE C CG    1 
ATOM   1064 C CD1   . PHE C 1 11 ? 2.657   27.996  17.566 1.00 12.02 ? 11  PHE C CD1   1 
ATOM   1065 C CD2   . PHE C 1 11 ? 3.042   25.657  17.781 1.00 14.84 ? 11  PHE C CD2   1 
ATOM   1066 C CE1   . PHE C 1 11 ? 2.612   28.117  18.941 1.00 12.73 ? 11  PHE C CE1   1 
ATOM   1067 C CE2   . PHE C 1 11 ? 3.000   25.772  19.156 1.00 7.53  ? 11  PHE C CE2   1 
ATOM   1068 C CZ    . PHE C 1 11 ? 2.784   27.003  19.736 1.00 13.87 ? 11  PHE C CZ    1 
ATOM   1069 N N     . LEU C 1 12 ? 5.238   24.655  15.215 1.00 13.62 ? 12  LEU C N     1 
ATOM   1070 C CA    . LEU C 1 12 ? 6.212   23.713  15.750 1.00 21.19 ? 12  LEU C CA    1 
ATOM   1071 C C     . LEU C 1 12 ? 7.624   24.082  15.315 1.00 20.78 ? 12  LEU C C     1 
ATOM   1072 O O     . LEU C 1 12 ? 8.580   23.920  16.082 1.00 14.80 ? 12  LEU C O     1 
ATOM   1073 C CB    . LEU C 1 12 ? 5.865   22.294  15.300 1.00 18.68 ? 12  LEU C CB    1 
ATOM   1074 C CG    . LEU C 1 12 ? 4.528   21.725  15.779 1.00 28.58 ? 12  LEU C CG    1 
ATOM   1075 C CD1   . LEU C 1 12 ? 4.327   20.314  15.241 1.00 20.79 ? 12  LEU C CD1   1 
ATOM   1076 C CD2   . LEU C 1 12 ? 4.443   21.728  17.299 1.00 14.02 ? 12  LEU C CD2   1 
ATOM   1077 N N     . ASN C 1 13 ? 7.776   24.581  14.087 1.00 25.05 ? 13  ASN C N     1 
ATOM   1078 C CA    . ASN C 1 13 ? 9.107   24.888  13.574 1.00 33.96 ? 13  ASN C CA    1 
ATOM   1079 C C     . ASN C 1 13 ? 9.751   26.028  14.352 1.00 24.20 ? 13  ASN C C     1 
ATOM   1080 O O     . ASN C 1 13 ? 10.972  26.039  14.549 1.00 29.91 ? 13  ASN C O     1 
ATOM   1081 C CB    . ASN C 1 13 ? 9.025   25.228  12.086 1.00 31.37 ? 13  ASN C CB    1 
ATOM   1082 C CG    . ASN C 1 13 ? 9.049   23.993  11.206 1.00 37.27 ? 13  ASN C CG    1 
ATOM   1083 O OD1   . ASN C 1 13 ? 9.911   23.128  11.355 1.00 32.57 ? 13  ASN C OD1   1 
ATOM   1084 N ND2   . ASN C 1 13 ? 8.097   23.904  10.283 1.00 44.64 ? 13  ASN C ND2   1 
ATOM   1085 N N     . ALA C 1 14 ? 8.951   27.000  14.798 1.00 22.62 ? 14  ALA C N     1 
ATOM   1086 C CA    . ALA C 1 14 ? 9.496   28.057  15.643 1.00 38.82 ? 14  ALA C CA    1 
ATOM   1087 C C     . ALA C 1 14 ? 10.151  27.468  16.884 1.00 32.82 ? 14  ALA C C     1 
ATOM   1088 O O     . ALA C 1 14 ? 11.239  27.897  17.286 1.00 38.86 ? 14  ALA C O     1 
ATOM   1089 C CB    . ALA C 1 14 ? 8.397   29.044  16.036 1.00 30.32 ? 14  ALA C CB    1 
ATOM   1090 N N     . LEU C 1 15 ? 9.501   26.482  17.504 1.00 34.14 ? 15  LEU C N     1 
ATOM   1091 C CA    . LEU C 1 15 ? 10.102  25.775  18.626 1.00 29.81 ? 15  LEU C CA    1 
ATOM   1092 C C     . LEU C 1 15 ? 11.201  24.823  18.174 1.00 32.60 ? 15  LEU C C     1 
ATOM   1093 O O     . LEU C 1 15 ? 12.100  24.517  18.963 1.00 32.12 ? 15  LEU C O     1 
ATOM   1094 C CB    . LEU C 1 15 ? 9.016   25.019  19.388 1.00 34.19 ? 15  LEU C CB    1 
ATOM   1095 C CG    . LEU C 1 15 ? 7.935   25.928  19.982 1.00 32.83 ? 15  LEU C CG    1 
ATOM   1096 C CD1   . LEU C 1 15 ? 6.553   25.523  19.482 1.00 34.99 ? 15  LEU C CD1   1 
ATOM   1097 C CD2   . LEU C 1 15 ? 7.984   25.926  21.501 1.00 28.46 ? 15  LEU C CD2   1 
ATOM   1098 N N     . ARG C 1 16 ? 11.160  24.365  16.919 1.00 36.12 ? 16  ARG C N     1 
ATOM   1099 C CA    . ARG C 1 16 ? 12.196  23.469  16.417 1.00 31.35 ? 16  ARG C CA    1 
ATOM   1100 C C     . ARG C 1 16 ? 13.474  24.212  16.058 1.00 43.30 ? 16  ARG C C     1 
ATOM   1101 O O     . ARG C 1 16 ? 14.554  23.613  16.067 1.00 43.07 ? 16  ARG C O     1 
ATOM   1102 C CB    . ARG C 1 16 ? 11.703  22.709  15.184 1.00 38.00 ? 16  ARG C CB    1 
ATOM   1103 C CG    . ARG C 1 16 ? 12.269  21.295  15.036 1.00 29.94 ? 16  ARG C CG    1 
ATOM   1104 C CD    . ARG C 1 16 ? 13.512  21.237  14.136 1.00 39.19 ? 16  ARG C CD    1 
ATOM   1105 N NE    . ARG C 1 16 ? 13.474  22.205  13.046 1.00 54.51 ? 16  ARG C NE    1 
ATOM   1106 C CZ    . ARG C 1 16 ? 12.644  22.145  12.013 1.00 39.83 ? 16  ARG C CZ    1 
ATOM   1107 N NH1   . ARG C 1 16 ? 11.795  21.141  11.864 1.00 46.76 ? 16  ARG C NH1   1 
ATOM   1108 N NH2   . ARG C 1 16 ? 12.670  23.115  11.104 1.00 40.52 ? 16  ARG C NH2   1 
ATOM   1109 N N     . ARG C 1 17 ? 13.375  25.502  15.745 1.00 41.47 ? 17  ARG C N     1 
ATOM   1110 C CA    . ARG C 1 17 ? 14.508  26.301  15.295 1.00 28.40 ? 17  ARG C CA    1 
ATOM   1111 C C     . ARG C 1 17 ? 15.163  27.092  16.418 1.00 26.65 ? 17  ARG C C     1 
ATOM   1112 O O     . ARG C 1 17 ? 16.394  27.141  16.495 1.00 28.37 ? 17  ARG C O     1 
ATOM   1113 C CB    . ARG C 1 17 ? 14.047  27.254  14.185 1.00 24.95 ? 17  ARG C CB    1 
ATOM   1114 C CG    . ARG C 1 17 ? 14.988  28.400  13.848 1.00 44.98 ? 17  ARG C CG    1 
ATOM   1115 C CD    . ARG C 1 17 ? 14.223  29.521  13.136 1.00 43.58 ? 17  ARG C CD    1 
ATOM   1116 N NE    . ARG C 1 17 ? 13.222  30.123  14.011 1.00 48.17 ? 17  ARG C NE    1 
ATOM   1117 C CZ    . ARG C 1 17 ? 11.943  30.297  13.701 1.00 44.24 ? 17  ARG C CZ    1 
ATOM   1118 N NH1   . ARG C 1 17 ? 11.454  29.922  12.530 1.00 42.13 ? 17  ARG C NH1   1 
ATOM   1119 N NH2   . ARG C 1 17 ? 11.135  30.869  14.589 1.00 34.94 ? 17  ARG C NH2   1 
ATOM   1120 N N     . GLU C 1 18 ? 14.374  27.725  17.282 1.00 29.42 ? 18  GLU C N     1 
ATOM   1121 C CA    . GLU C 1 18 ? 14.924  28.578  18.327 1.00 25.90 ? 18  GLU C CA    1 
ATOM   1122 C C     . GLU C 1 18 ? 15.360  27.802  19.561 1.00 35.15 ? 18  GLU C C     1 
ATOM   1123 O O     . GLU C 1 18 ? 15.895  28.410  20.495 1.00 32.27 ? 18  GLU C O     1 
ATOM   1124 C CB    . GLU C 1 18 ? 13.898  29.639  18.729 1.00 26.30 ? 18  GLU C CB    1 
ATOM   1125 C CG    . GLU C 1 18 ? 13.481  30.561  17.599 1.00 36.43 ? 18  GLU C CG    1 
ATOM   1126 C CD    . GLU C 1 18 ? 12.146  31.224  17.863 1.00 55.46 ? 18  GLU C CD    1 
ATOM   1127 O OE1   . GLU C 1 18 ? 11.594  31.846  16.931 1.00 56.39 ? 18  GLU C OE1   1 
ATOM   1128 O OE2   . GLU C 1 18 ? 11.649  31.120  19.004 1.00 54.63 ? 18  GLU C OE2   1 
ATOM   1129 N N     . ARG C 1 19 ? 15.148  26.488  19.593 1.00 29.00 ? 19  ARG C N     1 
ATOM   1130 C CA    . ARG C 1 19 ? 15.549  25.663  20.728 1.00 20.87 ? 19  ARG C CA    1 
ATOM   1131 C C     . ARG C 1 19 ? 14.967  26.210  22.027 1.00 25.92 ? 19  ARG C C     1 
ATOM   1132 O O     . ARG C 1 19 ? 15.666  26.393  23.026 1.00 31.15 ? 19  ARG C O     1 
ATOM   1133 C CB    . ARG C 1 19 ? 17.073  25.558  20.811 1.00 32.54 ? 19  ARG C CB    1 
ATOM   1134 C CG    . ARG C 1 19 ? 17.721  24.951  19.576 1.00 27.75 ? 19  ARG C CG    1 
ATOM   1135 C CD    . ARG C 1 19 ? 17.294  23.502  19.380 1.00 29.91 ? 19  ARG C CD    1 
ATOM   1136 N NE    . ARG C 1 19 ? 18.060  22.830  18.335 1.00 31.91 ? 19  ARG C NE    1 
ATOM   1137 C CZ    . ARG C 1 19 ? 17.999  23.131  17.045 1.00 38.55 ? 19  ARG C CZ    1 
ATOM   1138 N NH1   . ARG C 1 19 ? 17.237  24.117  16.598 1.00 44.50 ? 19  ARG C NH1   1 
ATOM   1139 N NH2   . ARG C 1 19 ? 18.722  22.426  16.180 1.00 38.62 ? 19  ARG C NH2   1 
ATOM   1140 N N     . VAL C 1 20 ? 13.663  26.466  22.011 1.00 37.19 ? 20  VAL C N     1 
ATOM   1141 C CA    . VAL C 1 20 ? 12.959  26.938  23.201 1.00 25.64 ? 20  VAL C CA    1 
ATOM   1142 C C     . VAL C 1 20 ? 12.366  25.729  23.916 1.00 20.13 ? 20  VAL C C     1 
ATOM   1143 O O     . VAL C 1 20 ? 11.683  24.913  23.280 1.00 17.49 ? 20  VAL C O     1 
ATOM   1144 C CB    . VAL C 1 20 ? 11.871  27.969  22.848 1.00 33.03 ? 20  VAL C CB    1 
ATOM   1145 C CG1   . VAL C 1 20 ? 11.282  27.711  21.467 1.00 33.48 ? 20  VAL C CG1   1 
ATOM   1146 C CG2   . VAL C 1 20 ? 10.764  27.965  23.901 1.00 26.26 ? 20  VAL C CG2   1 
ATOM   1147 N N     . PRO C 1 21 ? 12.601  25.561  25.219 1.00 24.27 ? 21  PRO C N     1 
ATOM   1148 C CA    . PRO C 1 21 ? 11.948  24.459  25.940 1.00 13.60 ? 21  PRO C CA    1 
ATOM   1149 C C     . PRO C 1 21 ? 10.434  24.567  25.839 1.00 23.07 ? 21  PRO C C     1 
ATOM   1150 O O     . PRO C 1 21 ? 9.859   25.649  25.978 1.00 26.33 ? 21  PRO C O     1 
ATOM   1151 C CB    . PRO C 1 21 ? 12.435  24.626  27.385 1.00 26.68 ? 21  PRO C CB    1 
ATOM   1152 C CG    . PRO C 1 21 ? 13.035  25.989  27.466 1.00 23.37 ? 21  PRO C CG    1 
ATOM   1153 C CD    . PRO C 1 21 ? 13.484  26.359  26.089 1.00 27.55 ? 21  PRO C CD    1 
ATOM   1154 N N     . ALA C 1 22 ? 9.786   23.429  25.593 1.00 27.18 ? 22  ALA C N     1 
ATOM   1155 C CA    . ALA C 1 22 ? 8.354   23.394  25.336 1.00 16.48 ? 22  ALA C CA    1 
ATOM   1156 C C     . ALA C 1 22 ? 7.680   22.470  26.342 1.00 17.89 ? 22  ALA C C     1 
ATOM   1157 O O     . ALA C 1 22 ? 8.315   21.624  26.977 1.00 32.83 ? 22  ALA C O     1 
ATOM   1158 C CB    . ALA C 1 22 ? 8.070   22.945  23.911 1.00 30.00 ? 22  ALA C CB    1 
ATOM   1159 N N     . SER C 1 23 ? 6.368   22.650  26.480 1.00 26.60 ? 23  SER C N     1 
ATOM   1160 C CA    . SER C 1 23 ? 5.529   21.806  27.319 1.00 13.58 ? 23  SER C CA    1 
ATOM   1161 C C     . SER C 1 23 ? 4.390   21.262  26.471 1.00 16.15 ? 23  SER C C     1 
ATOM   1162 O O     . SER C 1 23 ? 3.669   22.032  25.829 1.00 24.77 ? 23  SER C O     1 
ATOM   1163 C CB    . SER C 1 23 ? 4.977   22.588  28.514 1.00 10.92 ? 23  SER C CB    1 
ATOM   1164 O OG    . SER C 1 23 ? 5.487   22.080  29.734 1.00 20.36 ? 23  SER C OG    1 
ATOM   1165 N N     . ILE C 1 24 ? 4.235   19.941  26.464 1.00 19.02 ? 24  ILE C N     1 
ATOM   1166 C CA    . ILE C 1 24 ? 3.170   19.274  25.725 1.00 27.24 ? 24  ILE C CA    1 
ATOM   1167 C C     . ILE C 1 24 ? 2.217   18.662  26.741 1.00 9.85  ? 24  ILE C C     1 
ATOM   1168 O O     . ILE C 1 24 ? 2.592   17.751  27.489 1.00 11.36 ? 24  ILE C O     1 
ATOM   1169 C CB    . ILE C 1 24 ? 3.713   18.206  24.767 1.00 20.57 ? 24  ILE C CB    1 
ATOM   1170 C CG1   . ILE C 1 24 ? 4.437   18.860  23.589 1.00 23.05 ? 24  ILE C CG1   1 
ATOM   1171 C CG2   . ILE C 1 24 ? 2.578   17.316  24.275 1.00 7.75  ? 24  ILE C CG2   1 
ATOM   1172 C CD1   . ILE C 1 24 ? 5.249   17.887  22.752 1.00 15.08 ? 24  ILE C CD1   1 
ATOM   1173 N N     . TYR C 1 25 ? 0.984   19.157  26.766 1.00 6.55  ? 25  TYR C N     1 
ATOM   1174 C CA    . TYR C 1 25 ? -0.052  18.606  27.626 1.00 25.70 ? 25  TYR C CA    1 
ATOM   1175 C C     . TYR C 1 25 ? -0.828  17.543  26.861 1.00 9.47  ? 25  TYR C C     1 
ATOM   1176 O O     . TYR C 1 25 ? -1.274  17.779  25.734 1.00 7.27  ? 25  TYR C O     1 
ATOM   1177 C CB    . TYR C 1 25 ? -0.998  19.702  28.108 1.00 14.79 ? 25  TYR C CB    1 
ATOM   1178 C CG    . TYR C 1 25 ? -0.352  20.718  29.019 1.00 13.67 ? 25  TYR C CG    1 
ATOM   1179 C CD1   . TYR C 1 25 ? 0.331   21.809  28.500 1.00 11.15 ? 25  TYR C CD1   1 
ATOM   1180 C CD2   . TYR C 1 25 ? -0.432  20.589  30.398 1.00 6.47  ? 25  TYR C CD2   1 
ATOM   1181 C CE1   . TYR C 1 25 ? 0.919   22.743  29.330 1.00 12.82 ? 25  TYR C CE1   1 
ATOM   1182 C CE2   . TYR C 1 25 ? 0.148   21.518  31.235 1.00 9.82  ? 25  TYR C CE2   1 
ATOM   1183 C CZ    . TYR C 1 25 ? 0.822   22.593  30.697 1.00 13.26 ? 25  TYR C CZ    1 
ATOM   1184 O OH    . TYR C 1 25 ? 1.404   23.517  31.533 1.00 4.02  ? 25  TYR C OH    1 
ATOM   1185 N N     . LEU C 1 26 ? -0.981  16.377  27.474 1.00 15.32 ? 26  LEU C N     1 
ATOM   1186 C CA    . LEU C 1 26 ? -1.698  15.275  26.854 1.00 11.03 ? 26  LEU C CA    1 
ATOM   1187 C C     . LEU C 1 26 ? -3.186  15.359  27.179 1.00 12.42 ? 26  LEU C C     1 
ATOM   1188 O O     . LEU C 1 26 ? -3.612  16.078  28.087 1.00 5.62  ? 26  LEU C O     1 
ATOM   1189 C CB    . LEU C 1 26 ? -1.129  13.937  27.325 1.00 12.92 ? 26  LEU C CB    1 
ATOM   1190 C CG    . LEU C 1 26 ? 0.363   13.716  27.070 1.00 13.38 ? 26  LEU C CG    1 
ATOM   1191 C CD1   . LEU C 1 26 ? 0.783   12.337  27.556 1.00 14.24 ? 26  LEU C CD1   1 
ATOM   1192 C CD2   . LEU C 1 26 ? 0.696   13.889  25.596 1.00 10.93 ? 26  LEU C CD2   1 
ATOM   1193 N N     . VAL C 1 27 ? -3.980  14.597  26.423 1.00 9.76  ? 27  VAL C N     1 
ATOM   1194 C CA    . VAL C 1 27 ? -5.426  14.618  26.603 1.00 10.02 ? 27  VAL C CA    1 
ATOM   1195 C C     . VAL C 1 27 ? -5.828  14.182  28.004 1.00 8.49  ? 27  VAL C C     1 
ATOM   1196 O O     . VAL C 1 27 ? -6.967  14.421  28.421 1.00 17.36 ? 27  VAL C O     1 
ATOM   1197 C CB    . VAL C 1 27 ? -6.113  13.730  25.545 1.00 5.91  ? 27  VAL C CB    1 
ATOM   1198 C CG1   . VAL C 1 27 ? -6.047  14.388  24.177 1.00 12.81 ? 27  VAL C CG1   1 
ATOM   1199 C CG2   . VAL C 1 27 ? -5.479  12.344  25.513 1.00 10.31 ? 27  VAL C CG2   1 
ATOM   1200 N N     . ASN C 1 28 ? -4.923  13.546  28.745 1.00 7.31  ? 28  ASN C N     1 
ATOM   1201 C CA    . ASN C 1 28 ? -5.199  13.083  30.098 1.00 5.22  ? 28  ASN C CA    1 
ATOM   1202 C C     . ASN C 1 28 ? -4.579  13.982  31.162 1.00 15.77 ? 28  ASN C C     1 
ATOM   1203 O O     . ASN C 1 28 ? -4.517  13.591  32.333 1.00 11.89 ? 28  ASN C O     1 
ATOM   1204 C CB    . ASN C 1 28 ? -4.704  11.644  30.266 1.00 21.39 ? 28  ASN C CB    1 
ATOM   1205 C CG    . ASN C 1 28 ? -3.247  11.479  29.883 1.00 16.61 ? 28  ASN C CG    1 
ATOM   1206 O OD1   . ASN C 1 28 ? -2.756  12.137  28.966 1.00 14.99 ? 28  ASN C OD1   1 
ATOM   1207 N ND2   . ASN C 1 28 ? -2.553  10.582  30.572 1.00 23.76 ? 28  ASN C ND2   1 
ATOM   1208 N N     . GLY C 1 29 ? -4.125  15.177  30.785 1.00 8.02  ? 29  GLY C N     1 
ATOM   1209 C CA    . GLY C 1 29 ? -3.601  16.137  31.729 1.00 15.65 ? 29  GLY C CA    1 
ATOM   1210 C C     . GLY C 1 29 ? -2.113  16.049  31.983 1.00 22.04 ? 29  GLY C C     1 
ATOM   1211 O O     . GLY C 1 29 ? -1.547  16.978  32.575 1.00 6.24  ? 29  GLY C O     1 
ATOM   1212 N N     . ILE C 1 30 ? -1.459  14.969  31.560 1.00 11.00 ? 30  ILE C N     1 
ATOM   1213 C CA    . ILE C 1 30 ? -0.028  14.823  31.789 1.00 18.05 ? 30  ILE C CA    1 
ATOM   1214 C C     . ILE C 1 30 ? 0.722   15.897  31.013 1.00 5.19  ? 30  ILE C C     1 
ATOM   1215 O O     . ILE C 1 30 ? 0.454   16.132  29.827 1.00 12.02 ? 30  ILE C O     1 
ATOM   1216 C CB    . ILE C 1 30 ? 0.439   13.417  31.387 1.00 19.55 ? 30  ILE C CB    1 
ATOM   1217 C CG1   . ILE C 1 30 ? -0.336  12.349  32.166 1.00 14.28 ? 30  ILE C CG1   1 
ATOM   1218 C CG2   . ILE C 1 30 ? 1.933   13.262  31.620 1.00 13.80 ? 30  ILE C CG2   1 
ATOM   1219 C CD1   . ILE C 1 30 ? -0.432  12.606  33.656 1.00 21.43 ? 30  ILE C CD1   1 
ATOM   1220 N N     . LYS C 1 31 ? 1.673   16.546  31.678 1.00 11.83 ? 31  LYS C N     1 
ATOM   1221 C CA    . LYS C 1 31 ? 2.494   17.584  31.068 1.00 21.27 ? 31  LYS C CA    1 
ATOM   1222 C C     . LYS C 1 31 ? 3.861   17.003  30.729 1.00 18.37 ? 31  LYS C C     1 
ATOM   1223 O O     . LYS C 1 31 ? 4.607   16.595  31.626 1.00 8.28  ? 31  LYS C O     1 
ATOM   1224 C CB    . LYS C 1 31 ? 2.643   18.786  32.001 1.00 12.76 ? 31  LYS C CB    1 
ATOM   1225 C CG    . LYS C 1 31 ? 3.728   19.770  31.576 1.00 27.06 ? 31  LYS C CG    1 
ATOM   1226 C CD    . LYS C 1 31 ? 3.570   21.119  32.266 1.00 22.00 ? 31  LYS C CD    1 
ATOM   1227 C CE    . LYS C 1 31 ? 4.071   21.077  33.704 1.00 30.46 ? 31  LYS C CE    1 
ATOM   1228 N NZ    . LYS C 1 31 ? 4.353   22.442  34.235 1.00 24.34 ? 31  LYS C NZ    1 
ATOM   1229 N N     . LEU C 1 32 ? 4.144   16.943  29.433 1.00 10.46 ? 32  LEU C N     1 
ATOM   1230 C CA    . LEU C 1 32 ? 5.458   16.583  28.890 1.00 10.88 ? 32  LEU C CA    1 
ATOM   1231 C C     . LEU C 1 32 ? 6.319   17.860  28.859 1.00 30.79 ? 32  LEU C C     1 
ATOM   1232 O O     . LEU C 1 32 ? 5.749   18.950  28.878 1.00 36.71 ? 32  LEU C O     1 
ATOM   1233 C CB    . LEU C 1 32 ? 5.259   16.001  27.488 1.00 13.84 ? 32  LEU C CB    1 
ATOM   1234 C CG    . LEU C 1 32 ? 4.689   14.580  27.408 1.00 10.35 ? 32  LEU C CG    1 
ATOM   1235 C CD1   . LEU C 1 32 ? 5.247   13.846  26.205 1.00 8.30  ? 32  LEU C CD1   1 
ATOM   1236 C CD2   . LEU C 1 32 ? 4.958   13.771  28.668 1.00 6.56  ? 32  LEU C CD2   1 
ATOM   1237 N N     . GLN C 1 33 ? 7.636   17.723  28.852 1.00 26.65 ? 33  GLN C N     1 
ATOM   1238 C CA    . GLN C 1 33 ? 8.575   18.872  28.830 1.00 29.41 ? 33  GLN C CA    1 
ATOM   1239 C C     . GLN C 1 33 ? 9.855   18.439  28.112 1.00 35.89 ? 33  GLN C C     1 
ATOM   1240 O O     . GLN C 1 33 ? 10.358  17.351  28.406 1.00 29.98 ? 33  GLN C O     1 
ATOM   1241 C CB    . GLN C 1 33 ? 8.838   19.378  30.241 1.00 25.46 ? 33  GLN C CB    1 
ATOM   1242 C CG    . GLN C 1 33 ? 7.810   20.379  30.728 1.00 23.03 ? 33  GLN C CG    1 
ATOM   1243 C CD    . GLN C 1 33 ? 7.904   20.579  32.217 1.00 30.67 ? 33  GLN C CD    1 
ATOM   1244 O OE1   . GLN C 1 33 ? 7.655   19.668  32.997 1.00 20.58 ? 33  GLN C OE1   1 
ATOM   1245 N NE2   . GLN C 1 33 ? 8.265   21.783  32.621 1.00 43.85 ? 33  GLN C NE2   1 
ATOM   1246 N N     . GLY C 1 34 ? 10.330  19.238  27.179 1.00 28.92 ? 34  GLY C N     1 
ATOM   1247 C CA    . GLY C 1 34 ? 11.565  18.952  26.456 1.00 26.15 ? 34  GLY C CA    1 
ATOM   1248 C C     . GLY C 1 34 ? 11.735  19.915  25.326 1.00 20.81 ? 34  GLY C C     1 
ATOM   1249 O O     . GLY C 1 34 ? 11.484  21.057  25.556 1.00 22.34 ? 34  GLY C O     1 
ATOM   1250 N N     . GLN C 1 35 ? 12.097  19.452  24.143 1.00 24.78 ? 35  GLN C N     1 
ATOM   1251 C CA    . GLN C 1 35 ? 12.362  20.319  22.977 1.00 20.02 ? 35  GLN C CA    1 
ATOM   1252 C C     . GLN C 1 35 ? 11.882  19.611  21.724 1.00 14.94 ? 35  GLN C C     1 
ATOM   1253 O O     . GLN C 1 35 ? 12.123  18.413  21.603 1.00 16.51 ? 35  GLN C O     1 
ATOM   1254 C CB    . GLN C 1 35 ? 13.856  20.628  22.854 1.00 18.80 ? 35  GLN C CB    1 
ATOM   1255 C CG    . GLN C 1 35 ? 14.387  21.536  23.958 1.00 32.51 ? 35  GLN C CG    1 
ATOM   1256 C CD    . GLN C 1 35 ? 14.930  22.850  23.452 1.00 22.46 ? 35  GLN C CD    1 
ATOM   1257 O OE1   . GLN C 1 35 ? 15.306  22.986  22.295 1.00 30.69 ? 35  GLN C OE1   1 
ATOM   1258 N NE2   . GLN C 1 35 ? 14.975  23.837  24.330 1.00 29.61 ? 35  GLN C NE2   1 
ATOM   1259 N N     . ILE C 1 36 ? 11.215  20.344  20.849 1.00 12.89 ? 36  ILE C N     1 
ATOM   1260 C CA    . ILE C 1 36 ? 10.688  19.762  19.600 1.00 23.14 ? 36  ILE C CA    1 
ATOM   1261 C C     . ILE C 1 36 ? 11.940  19.390  18.825 1.00 14.23 ? 36  ILE C C     1 
ATOM   1262 O O     . ILE C 1 36 ? 12.681  20.282  18.479 1.00 29.98 ? 36  ILE C O     1 
ATOM   1263 C CB    . ILE C 1 36 ? 9.764   20.712  18.815 1.00 20.36 ? 36  ILE C CB    1 
ATOM   1264 C CG1   . ILE C 1 36 ? 8.593   21.237  19.651 1.00 36.61 ? 36  ILE C CG1   1 
ATOM   1265 C CG2   . ILE C 1 36 ? 9.308   20.042  17.529 1.00 25.72 ? 36  ILE C CG2   1 
ATOM   1266 C CD1   . ILE C 1 36 ? 7.284   20.555  19.382 1.00 14.22 ? 36  ILE C CD1   1 
ATOM   1267 N N     . GLU C 1 37 ? 12.176  18.117  18.633 1.00 24.26 ? 37  GLU C N     1 
ATOM   1268 C CA    . GLU C 1 37 ? 13.305  17.656  17.808 1.00 14.09 ? 37  GLU C CA    1 
ATOM   1269 C C     . GLU C 1 37 ? 12.807  17.705  16.358 1.00 10.82 ? 37  GLU C C     1 
ATOM   1270 O O     . GLU C 1 37 ? 13.443  18.374  15.573 1.00 30.76 ? 37  GLU C O     1 
ATOM   1271 C CB    . GLU C 1 37 ? 13.721  16.298  18.358 1.00 42.57 ? 37  GLU C CB    1 
ATOM   1272 C CG    . GLU C 1 37 ? 15.190  16.133  18.629 1.00 63.11 ? 37  GLU C CG    1 
ATOM   1273 C CD    . GLU C 1 37 ? 15.493  14.675  18.906 1.00 78.51 ? 37  GLU C CD    1 
ATOM   1274 O OE1   . GLU C 1 37 ? 16.342  14.099  18.223 1.00 91.39 ? 37  GLU C OE1   1 
ATOM   1275 O OE2   . GLU C 1 37 ? 14.822  14.117  19.769 1.00 82.09 ? 37  GLU C OE2   1 
ATOM   1276 N N     . SER C 1 38 ? 11.703  17.021  16.043 1.00 30.59 ? 38  SER C N     1 
ATOM   1277 C CA    . SER C 1 38 ? 11.075  16.995  14.702 1.00 28.48 ? 38  SER C CA    1 
ATOM   1278 C C     . SER C 1 38 ? 9.593   16.589  14.765 1.00 26.85 ? 38  SER C C     1 
ATOM   1279 O O     . SER C 1 38 ? 9.098   16.341  15.877 1.00 20.83 ? 38  SER C O     1 
ATOM   1280 C CB    . SER C 1 38 ? 11.806  16.103  13.773 1.00 32.84 ? 38  SER C CB    1 
ATOM   1281 O OG    . SER C 1 38 ? 12.088  14.863  14.399 1.00 43.94 ? 38  SER C OG    1 
ATOM   1282 N N     . PHE C 1 39 ? 8.937   16.483  13.592 1.00 25.53 ? 39  PHE C N     1 
ATOM   1283 C CA    . PHE C 1 39 ? 7.479   16.228  13.548 1.00 27.20 ? 39  PHE C CA    1 
ATOM   1284 C C     . PHE C 1 39 ? 7.070   15.899  12.129 1.00 24.44 ? 39  PHE C C     1 
ATOM   1285 O O     . PHE C 1 39 ? 7.830   16.185  11.191 1.00 22.82 ? 39  PHE C O     1 
ATOM   1286 C CB    . PHE C 1 39 ? 6.668   17.416  14.068 1.00 13.21 ? 39  PHE C CB    1 
ATOM   1287 C CG    . PHE C 1 39 ? 6.951   18.681  13.280 1.00 22.96 ? 39  PHE C CG    1 
ATOM   1288 C CD1   . PHE C 1 39 ? 6.241   18.964  12.122 1.00 19.55 ? 39  PHE C CD1   1 
ATOM   1289 C CD2   . PHE C 1 39 ? 7.954   19.554  13.676 1.00 31.51 ? 39  PHE C CD2   1 
ATOM   1290 C CE1   . PHE C 1 39 ? 6.512   20.107  11.397 1.00 33.42 ? 39  PHE C CE1   1 
ATOM   1291 C CE2   . PHE C 1 39 ? 8.226   20.692  12.938 1.00 32.31 ? 39  PHE C CE2   1 
ATOM   1292 C CZ    . PHE C 1 39 ? 7.500   20.964  11.806 1.00 31.18 ? 39  PHE C CZ    1 
ATOM   1293 N N     . ASP C 1 40 ? 5.891   15.313  11.994 1.00 22.57 ? 40  ASP C N     1 
ATOM   1294 C CA    . ASP C 1 40 ? 5.305   14.990  10.675 1.00 24.65 ? 40  ASP C CA    1 
ATOM   1295 C C     . ASP C 1 40 ? 3.791   15.045  10.859 1.00 26.83 ? 40  ASP C C     1 
ATOM   1296 O O     . ASP C 1 40 ? 3.378   15.582  11.891 1.00 35.35 ? 40  ASP C O     1 
ATOM   1297 C CB    . ASP C 1 40 ? 5.839   13.686  10.138 1.00 25.28 ? 40  ASP C CB    1 
ATOM   1298 C CG    . ASP C 1 40 ? 5.386   12.439  10.870 1.00 36.37 ? 40  ASP C CG    1 
ATOM   1299 O OD1   . ASP C 1 40 ? 4.807   12.560  11.961 1.00 36.55 ? 40  ASP C OD1   1 
ATOM   1300 O OD2   . ASP C 1 40 ? 5.603   11.369  10.318 1.00 31.88 ? 40  ASP C OD2   1 
ATOM   1301 N N     . GLN C 1 41 ? 3.018   14.496  9.939  1.00 21.66 ? 41  GLN C N     1 
ATOM   1302 C CA    . GLN C 1 41 ? 1.541   14.578  9.964  1.00 23.02 ? 41  GLN C CA    1 
ATOM   1303 C C     . GLN C 1 41 ? 0.958   13.961  11.238 1.00 25.71 ? 41  GLN C C     1 
ATOM   1304 O O     . GLN C 1 41 ? -0.112  14.427  11.638 1.00 33.18 ? 41  GLN C O     1 
ATOM   1305 C CB    . GLN C 1 41 ? 1.037   13.859  8.718  1.00 35.84 ? 41  GLN C CB    1 
ATOM   1306 C CG    . GLN C 1 41 ? -0.276  14.405  8.170  1.00 47.23 ? 41  GLN C CG    1 
ATOM   1307 C CD    . GLN C 1 41 ? -0.987  13.443  7.244  1.00 34.68 ? 41  GLN C CD    1 
ATOM   1308 O OE1   . GLN C 1 41 ? -2.217  13.444  7.137  1.00 38.87 ? 41  GLN C OE1   1 
ATOM   1309 N NE2   . GLN C 1 41 ? -0.219  12.610  6.559  1.00 46.74 ? 41  GLN C NE2   1 
ATOM   1310 N N     . PHE C 1 42 ? 1.586   12.931  11.803 1.00 27.07 ? 42  PHE C N     1 
ATOM   1311 C CA    . PHE C 1 42 ? 1.007   12.195  12.956 1.00 20.86 ? 42  PHE C CA    1 
ATOM   1312 C C     . PHE C 1 42 ? 1.787   12.298  14.252 1.00 12.95 ? 42  PHE C C     1 
ATOM   1313 O O     . PHE C 1 42 ? 1.163   11.970  15.236 1.00 11.95 ? 42  PHE C O     1 
ATOM   1314 C CB    . PHE C 1 42 ? 0.929   10.750  12.469 1.00 21.32 ? 42  PHE C CB    1 
ATOM   1315 C CG    . PHE C 1 42 ? 0.092   10.600  11.211 1.00 20.19 ? 42  PHE C CG    1 
ATOM   1316 C CD1   . PHE C 1 42 ? 0.647   10.112  10.036 1.00 28.33 ? 42  PHE C CD1   1 
ATOM   1317 C CD2   . PHE C 1 42 ? -1.243  10.978  11.202 1.00 24.36 ? 42  PHE C CD2   1 
ATOM   1318 C CE1   . PHE C 1 42 ? -0.119  9.988   8.891  1.00 26.28 ? 42  PHE C CE1   1 
ATOM   1319 C CE2   . PHE C 1 42 ? -2.005  10.854  10.055 1.00 38.89 ? 42  PHE C CE2   1 
ATOM   1320 C CZ    . PHE C 1 42 ? -1.441  10.362  8.901  1.00 39.48 ? 42  PHE C CZ    1 
ATOM   1321 N N     . VAL C 1 43 ? 3.052   12.717  14.260 1.00 7.93  ? 43  VAL C N     1 
ATOM   1322 C CA    . VAL C 1 43 ? 3.837   12.631  15.524 1.00 25.95 ? 43  VAL C CA    1 
ATOM   1323 C C     . VAL C 1 43 ? 4.790   13.800  15.784 1.00 32.90 ? 43  VAL C C     1 
ATOM   1324 O O     . VAL C 1 43 ? 5.103   14.553  14.851 1.00 21.44 ? 43  VAL C O     1 
ATOM   1325 C CB    . VAL C 1 43 ? 4.628   11.310  15.630 1.00 27.70 ? 43  VAL C CB    1 
ATOM   1326 C CG1   . VAL C 1 43 ? 3.788   10.094  15.265 1.00 8.93  ? 43  VAL C CG1   1 
ATOM   1327 C CG2   . VAL C 1 43 ? 5.913   11.338  14.818 1.00 25.54 ? 43  VAL C CG2   1 
ATOM   1328 N N     . ILE C 1 44 ? 5.223   13.926  17.032 1.00 24.44 ? 44  ILE C N     1 
ATOM   1329 C CA    . ILE C 1 44 ? 6.229   14.927  17.436 1.00 26.99 ? 44  ILE C CA    1 
ATOM   1330 C C     . ILE C 1 44 ? 7.282   14.166  18.221 1.00 27.73 ? 44  ILE C C     1 
ATOM   1331 O O     . ILE C 1 44 ? 6.904   13.415  19.048 1.00 13.37 ? 44  ILE C O     1 
ATOM   1332 C CB    . ILE C 1 44 ? 5.647   16.039  18.317 1.00 22.18 ? 44  ILE C CB    1 
ATOM   1333 C CG1   . ILE C 1 44 ? 4.488   16.768  17.633 1.00 22.89 ? 44  ILE C CG1   1 
ATOM   1334 C CG2   . ILE C 1 44 ? 6.756   16.988  18.726 1.00 21.60 ? 44  ILE C CG2   1 
ATOM   1335 C CD1   . ILE C 1 44 ? 3.795   17.775  18.511 1.00 17.80 ? 44  ILE C CD1   1 
ATOM   1336 N N     . LEU C 1 45 ? 8.556   14.426  18.010 1.00 38.87 ? 45  LEU C N     1 
ATOM   1337 C CA    . LEU C 1 45 ? 9.590   13.828  18.886 1.00 14.92 ? 45  LEU C CA    1 
ATOM   1338 C C     . LEU C 1 45 ? 9.944   14.846  19.966 1.00 17.13 ? 45  LEU C C     1 
ATOM   1339 O O     . LEU C 1 45 ? 10.259  15.991  19.621 1.00 11.51 ? 45  LEU C O     1 
ATOM   1340 C CB    . LEU C 1 45 ? 10.783  13.387  18.061 1.00 23.43 ? 45  LEU C CB    1 
ATOM   1341 C CG    . LEU C 1 45 ? 10.469  12.395  16.948 1.00 31.28 ? 45  LEU C CG    1 
ATOM   1342 C CD1   . LEU C 1 45 ? 9.446   11.368  17.403 1.00 36.09 ? 45  LEU C CD1   1 
ATOM   1343 C CD2   . LEU C 1 45 ? 9.987   13.126  15.711 1.00 30.48 ? 45  LEU C CD2   1 
ATOM   1344 N N     . LEU C 1 46 ? 9.803   14.460  21.213 1.00 17.48 ? 46  LEU C N     1 
ATOM   1345 C CA    . LEU C 1 46 ? 10.155  15.302  22.366 1.00 24.51 ? 46  LEU C CA    1 
ATOM   1346 C C     . LEU C 1 46 ? 11.474  14.782  22.938 1.00 26.89 ? 46  LEU C C     1 
ATOM   1347 O O     . LEU C 1 46 ? 11.628  13.564  23.115 1.00 5.33  ? 46  LEU C O     1 
ATOM   1348 C CB    . LEU C 1 46 ? 9.036   15.303  23.402 1.00 8.28  ? 46  LEU C CB    1 
ATOM   1349 C CG    . LEU C 1 46 ? 9.235   16.242  24.586 1.00 19.42 ? 46  LEU C CG    1 
ATOM   1350 C CD1   . LEU C 1 46 ? 9.270   17.690  24.129 1.00 19.58 ? 46  LEU C CD1   1 
ATOM   1351 C CD2   . LEU C 1 46 ? 8.143   16.027  25.613 1.00 10.34 ? 46  LEU C CD2   1 
ATOM   1352 N N     . LYS C 1 47 ? 12.370  15.693  23.256 1.00 27.03 ? 47  LYS C N     1 
ATOM   1353 C CA    . LYS C 1 47 ? 13.731  15.305  23.674 1.00 25.09 ? 47  LYS C CA    1 
ATOM   1354 C C     . LYS C 1 47 ? 14.051  15.694  25.109 1.00 19.34 ? 47  LYS C C     1 
ATOM   1355 O O     . LYS C 1 47 ? 13.635  16.756  25.576 1.00 31.19 ? 47  LYS C O     1 
ATOM   1356 C CB    . LYS C 1 47 ? 14.724  15.941  22.711 1.00 31.76 ? 47  LYS C CB    1 
ATOM   1357 C CG    . LYS C 1 47 ? 15.818  15.007  22.218 1.00 41.80 ? 47  LYS C CG    1 
ATOM   1358 C CD    . LYS C 1 47 ? 16.887  14.675  23.219 1.00 56.93 ? 47  LYS C CD    1 
ATOM   1359 C CE    . LYS C 1 47 ? 16.885  13.197  23.536 1.00 58.19 ? 47  LYS C CE    1 
ATOM   1360 N NZ    . LYS C 1 47 ? 17.641  12.403  22.537 1.00 67.81 ? 47  LYS C NZ    1 
ATOM   1361 N N     . ASN C 1 48 ? 14.820  14.853  25.756 1.00 21.69 ? 48  ASN C N     1 
ATOM   1362 C CA    . ASN C 1 48 ? 15.306  15.121  27.121 1.00 46.02 ? 48  ASN C CA    1 
ATOM   1363 C C     . ASN C 1 48 ? 16.408  14.062  27.370 1.00 51.50 ? 48  ASN C C     1 
ATOM   1364 O O     . ASN C 1 48 ? 17.467  14.200  26.758 1.00 42.84 ? 48  ASN C O     1 
ATOM   1365 C CB    . ASN C 1 48 ? 14.107  15.204  28.058 1.00 39.61 ? 48  ASN C CB    1 
ATOM   1366 C CG    . ASN C 1 48 ? 14.241  16.274  29.121 1.00 47.88 ? 48  ASN C CG    1 
ATOM   1367 O OD1   . ASN C 1 48 ? 15.346  16.698  29.453 1.00 41.35 ? 48  ASN C OD1   1 
ATOM   1368 N ND2   . ASN C 1 48 ? 13.118  16.713  29.663 1.00 23.85 ? 48  ASN C ND2   1 
ATOM   1369 N N     . THR C 1 49 ? 16.194  13.048  28.217 1.00 44.65 ? 49  THR C N     1 
ATOM   1370 C CA    . THR C 1 49 ? 17.171  11.935  28.402 1.00 49.76 ? 49  THR C CA    1 
ATOM   1371 C C     . THR C 1 49 ? 17.168  11.164  27.088 1.00 43.04 ? 49  THR C C     1 
ATOM   1372 O O     . THR C 1 49 ? 18.237  11.046  26.503 1.00 39.56 ? 49  THR C O     1 
ATOM   1373 C CB    . THR C 1 49 ? 16.862  11.075  29.624 1.00 51.25 ? 49  THR C CB    1 
ATOM   1374 O OG1   . THR C 1 49 ? 15.577  10.485  29.423 1.00 56.97 ? 49  THR C OG1   1 
ATOM   1375 C CG2   . THR C 1 49 ? 16.889  11.857  30.917 1.00 67.14 ? 49  THR C CG2   1 
ATOM   1376 N N     . VAL C 1 50 ? 15.993  10.720  26.651 1.00 40.64 ? 50  VAL C N     1 
ATOM   1377 C CA    . VAL C 1 50 ? 15.843  10.069  25.319 1.00 34.55 ? 50  VAL C CA    1 
ATOM   1378 C C     . VAL C 1 50 ? 14.911  10.887  24.415 1.00 31.86 ? 50  VAL C C     1 
ATOM   1379 O O     . VAL C 1 50 ? 14.225  11.771  24.909 1.00 11.94 ? 50  VAL C O     1 
ATOM   1380 C CB    . VAL C 1 50 ? 15.353  8.621   25.482 1.00 47.84 ? 50  VAL C CB    1 
ATOM   1381 C CG1   . VAL C 1 50 ? 16.340  7.767   26.255 1.00 40.91 ? 50  VAL C CG1   1 
ATOM   1382 C CG2   . VAL C 1 50 ? 13.961  8.540   26.086 1.00 30.91 ? 50  VAL C CG2   1 
ATOM   1383 N N     . SER C 1 51 ? 14.906  10.590  23.124 1.00 33.52 ? 51  SER C N     1 
ATOM   1384 C CA    . SER C 1 51 ? 13.984  11.194  22.143 1.00 22.07 ? 51  SER C CA    1 
ATOM   1385 C C     . SER C 1 51 ? 12.729  10.308  22.032 1.00 35.38 ? 51  SER C C     1 
ATOM   1386 O O     . SER C 1 51 ? 12.785  9.288   21.325 1.00 20.96 ? 51  SER C O     1 
ATOM   1387 C CB    . SER C 1 51 ? 14.655  11.368  20.825 1.00 32.72 ? 51  SER C CB    1 
ATOM   1388 O OG    . SER C 1 51 ? 13.744  11.765  19.818 1.00 48.56 ? 51  SER C OG    1 
ATOM   1389 N N     . GLN C 1 52 ? 11.641  10.679  22.696 1.00 25.75 ? 52  GLN C N     1 
ATOM   1390 C CA    . GLN C 1 52 ? 10.375  9.912   22.688 1.00 17.91 ? 52  GLN C CA    1 
ATOM   1391 C C     . GLN C 1 52 ? 9.439   10.390  21.606 1.00 19.13 ? 52  GLN C C     1 
ATOM   1392 O O     . GLN C 1 52 ? 9.498   11.584  21.283 1.00 27.62 ? 52  GLN C O     1 
ATOM   1393 C CB    . GLN C 1 52 ? 9.619   10.075  23.992 1.00 13.22 ? 52  GLN C CB    1 
ATOM   1394 C CG    . GLN C 1 52 ? 9.011   11.443  24.228 1.00 19.63 ? 52  GLN C CG    1 
ATOM   1395 C CD    . GLN C 1 52 ? 8.419   11.488  25.612 1.00 12.99 ? 52  GLN C CD    1 
ATOM   1396 O OE1   . GLN C 1 52 ? 7.487   10.752  25.930 1.00 8.66  ? 52  GLN C OE1   1 
ATOM   1397 N NE2   . GLN C 1 52 ? 8.971   12.346  26.451 1.00 13.22 ? 52  GLN C NE2   1 
ATOM   1398 N N     . MET C 1 53 ? 8.556   9.514   21.166 1.00 14.29 ? 53  MET C N     1 
ATOM   1399 C CA    . MET C 1 53 ? 7.628   9.823   20.058 1.00 17.02 ? 53  MET C CA    1 
ATOM   1400 C C     . MET C 1 53 ? 6.232   10.055  20.635 1.00 16.95 ? 53  MET C C     1 
ATOM   1401 O O     . MET C 1 53 ? 5.603   9.107   21.062 1.00 11.59 ? 53  MET C O     1 
ATOM   1402 C CB    . MET C 1 53 ? 7.609   8.696   19.029 1.00 19.60 ? 53  MET C CB    1 
ATOM   1403 C CG    . MET C 1 53 ? 6.487   8.796   18.035 1.00 16.37 ? 53  MET C CG    1 
ATOM   1404 S SD    . MET C 1 53 ? 6.653   7.566   16.742 1.00 17.75 ? 53  MET C SD    1 
ATOM   1405 C CE    . MET C 1 53 ? 6.304   6.079   17.679 1.00 13.69 ? 53  MET C CE    1 
ATOM   1406 N N     . VAL C 1 54 ? 5.790   11.294  20.601 1.00 25.52 ? 54  VAL C N     1 
ATOM   1407 C CA    . VAL C 1 54 ? 4.491   11.659  21.153 1.00 19.80 ? 54  VAL C CA    1 
ATOM   1408 C C     . VAL C 1 54 ? 3.491   11.725  20.009 1.00 19.19 ? 54  VAL C C     1 
ATOM   1409 O O     . VAL C 1 54 ? 3.694   12.463  19.037 1.00 4.64  ? 54  VAL C O     1 
ATOM   1410 C CB    . VAL C 1 54 ? 4.558   12.996  21.908 1.00 25.98 ? 54  VAL C CB    1 
ATOM   1411 C CG1   . VAL C 1 54 ? 3.242   13.268  22.622 1.00 22.39 ? 54  VAL C CG1   1 
ATOM   1412 C CG2   . VAL C 1 54 ? 5.722   12.991  22.890 1.00 9.45  ? 54  VAL C CG2   1 
ATOM   1413 N N     . TYR C 1 55 ? 2.410   10.956  20.120 1.00 17.78 ? 55  TYR C N     1 
ATOM   1414 C CA    . TYR C 1 55 ? 1.384   10.936  19.086 1.00 17.41 ? 55  TYR C CA    1 
ATOM   1415 C C     . TYR C 1 55 ? 0.536   12.199  19.159 1.00 11.08 ? 55  TYR C C     1 
ATOM   1416 O O     . TYR C 1 55 ? 0.082   12.594  20.237 1.00 9.09  ? 55  TYR C O     1 
ATOM   1417 C CB    . TYR C 1 55 ? 0.508   9.696   19.237 1.00 18.99 ? 55  TYR C CB    1 
ATOM   1418 C CG    . TYR C 1 55 ? 1.040   8.494   18.494 1.00 9.37  ? 55  TYR C CG    1 
ATOM   1419 C CD1   . TYR C 1 55 ? 0.827   8.351   17.132 1.00 3.85  ? 55  TYR C CD1   1 
ATOM   1420 C CD2   . TYR C 1 55 ? 1.765   7.509   19.151 1.00 12.26 ? 55  TYR C CD2   1 
ATOM   1421 C CE1   . TYR C 1 55 ? 1.311   7.260   16.447 1.00 7.13  ? 55  TYR C CE1   1 
ATOM   1422 C CE2   . TYR C 1 55 ? 2.257   6.411   18.471 1.00 14.97 ? 55  TYR C CE2   1 
ATOM   1423 C CZ    . TYR C 1 55 ? 2.029   6.294   17.118 1.00 14.27 ? 55  TYR C CZ    1 
ATOM   1424 O OH    . TYR C 1 55 ? 2.514   5.204   16.431 1.00 14.40 ? 55  TYR C OH    1 
ATOM   1425 N N     . LYS C 1 56 ? 0.317   12.828  18.002 1.00 3.19  ? 56  LYS C N     1 
ATOM   1426 C CA    . LYS C 1 56 ? -0.436  14.076  17.973 1.00 21.14 ? 56  LYS C CA    1 
ATOM   1427 C C     . LYS C 1 56 ? -1.858  13.880  18.486 1.00 23.44 ? 56  LYS C C     1 
ATOM   1428 O O     . LYS C 1 56 ? -2.385  14.732  19.212 1.00 6.82  ? 56  LYS C O     1 
ATOM   1429 C CB    . LYS C 1 56 ? -0.453  14.642  16.553 1.00 17.46 ? 56  LYS C CB    1 
ATOM   1430 C CG    . LYS C 1 56 ? 0.794   15.431  16.177 1.00 18.23 ? 56  LYS C CG    1 
ATOM   1431 C CD    . LYS C 1 56 ? 0.877   15.634  14.668 1.00 29.59 ? 56  LYS C CD    1 
ATOM   1432 C CE    . LYS C 1 56 ? 1.570   16.941  14.311 1.00 35.18 ? 56  LYS C CE    1 
ATOM   1433 N NZ    . LYS C 1 56 ? 1.245   17.390  12.925 1.00 36.58 ? 56  LYS C NZ    1 
ATOM   1434 N N     . HIS C 1 57 ? -2.498  12.763  18.125 1.00 14.34 ? 57  HIS C N     1 
ATOM   1435 C CA    . HIS C 1 57 ? -3.888  12.556  18.517 1.00 12.33 ? 57  HIS C CA    1 
ATOM   1436 C C     . HIS C 1 57 ? -4.061  12.524  20.030 1.00 11.95 ? 57  HIS C C     1 
ATOM   1437 O O     . HIS C 1 57 ? -5.174  12.746  20.520 1.00 12.59 ? 57  HIS C O     1 
ATOM   1438 C CB    . HIS C 1 57 ? -4.437  11.267  17.893 1.00 9.67  ? 57  HIS C CB    1 
ATOM   1439 C CG    . HIS C 1 57 ? -3.686  10.029  18.276 1.00 12.46 ? 57  HIS C CG    1 
ATOM   1440 N ND1   . HIS C 1 57 ? -3.084  9.210   17.345 1.00 5.29  ? 57  HIS C ND1   1 
ATOM   1441 C CD2   . HIS C 1 57 ? -3.467  9.451   19.482 1.00 9.19  ? 57  HIS C CD2   1 
ATOM   1442 C CE1   . HIS C 1 57 ? -2.509  8.193   17.962 1.00 11.91 ? 57  HIS C CE1   1 
ATOM   1443 N NE2   . HIS C 1 57 ? -2.728  8.315   19.259 1.00 8.30  ? 57  HIS C NE2   1 
ATOM   1444 N N     . ALA C 1 58 ? -2.994  12.257  20.780 1.00 5.88  ? 58  ALA C N     1 
ATOM   1445 C CA    . ALA C 1 58 ? -3.034  12.319  22.234 1.00 10.23 ? 58  ALA C CA    1 
ATOM   1446 C C     . ALA C 1 58 ? -2.609  13.677  22.775 1.00 5.22  ? 58  ALA C C     1 
ATOM   1447 O O     . ALA C 1 58 ? -2.520  13.843  23.996 1.00 4.70  ? 58  ALA C O     1 
ATOM   1448 C CB    . ALA C 1 58 ? -2.140  11.230  22.835 1.00 5.73  ? 58  ALA C CB    1 
ATOM   1449 N N     . ILE C 1 59 ? -2.346  14.646  21.903 1.00 5.63  ? 59  ILE C N     1 
ATOM   1450 C CA    . ILE C 1 59 ? -1.915  15.978  22.308 1.00 12.93 ? 59  ILE C CA    1 
ATOM   1451 C C     . ILE C 1 59 ? -3.128  16.895  22.339 1.00 24.00 ? 59  ILE C C     1 
ATOM   1452 O O     . ILE C 1 59 ? -3.900  16.952  21.373 1.00 18.11 ? 59  ILE C O     1 
ATOM   1453 C CB    . ILE C 1 59 ? -0.837  16.531  21.360 1.00 17.32 ? 59  ILE C CB    1 
ATOM   1454 C CG1   . ILE C 1 59 ? 0.434   15.682  21.443 1.00 16.69 ? 59  ILE C CG1   1 
ATOM   1455 C CG2   . ILE C 1 59 ? -0.537  17.990  21.689 1.00 25.29 ? 59  ILE C CG2   1 
ATOM   1456 C CD1   . ILE C 1 59 ? 1.524   16.105  20.476 1.00 6.72  ? 59  ILE C CD1   1 
ATOM   1457 N N     . SER C 1 60 ? -3.298  17.613  23.448 1.00 19.19 ? 60  SER C N     1 
ATOM   1458 C CA    . SER C 1 60 ? -4.288  18.678  23.543 1.00 14.77 ? 60  SER C CA    1 
ATOM   1459 C C     . SER C 1 60 ? -3.677  20.046  23.267 1.00 14.50 ? 60  SER C C     1 
ATOM   1460 O O     . SER C 1 60 ? -4.180  20.791  22.421 1.00 15.81 ? 60  SER C O     1 
ATOM   1461 C CB    . SER C 1 60 ? -4.947  18.676  24.928 1.00 20.38 ? 60  SER C CB    1 
ATOM   1462 O OG    . SER C 1 60 ? -3.993  18.895  25.951 1.00 23.42 ? 60  SER C OG    1 
ATOM   1463 N N     . THR C 1 61 ? -2.588  20.385  23.958 1.00 6.13  ? 61  THR C N     1 
ATOM   1464 C CA    . THR C 1 61 ? -1.937  21.676  23.795 1.00 18.90 ? 61  THR C CA    1 
ATOM   1465 C C     . THR C 1 61 ? -0.425  21.500  23.790 1.00 27.19 ? 61  THR C C     1 
ATOM   1466 O O     . THR C 1 61 ? 0.113   20.503  24.279 1.00 26.88 ? 61  THR C O     1 
ATOM   1467 C CB    . THR C 1 61 ? -2.327  22.657  24.911 1.00 10.52 ? 61  THR C CB    1 
ATOM   1468 O OG1   . THR C 1 61 ? -3.688  22.433  25.297 1.00 17.92 ? 61  THR C OG1   1 
ATOM   1469 C CG2   . THR C 1 61 ? -2.163  24.096  24.443 1.00 33.70 ? 61  THR C CG2   1 
ATOM   1470 N N     . VAL C 1 62 ? 0.252   22.496  23.222 1.00 18.67 ? 62  VAL C N     1 
ATOM   1471 C CA    . VAL C 1 62 ? 1.707   22.610  23.260 1.00 19.51 ? 62  VAL C CA    1 
ATOM   1472 C C     . VAL C 1 62 ? 2.015   24.091  23.435 1.00 28.15 ? 62  VAL C C     1 
ATOM   1473 O O     . VAL C 1 62 ? 1.760   24.892  22.528 1.00 4.21  ? 62  VAL C O     1 
ATOM   1474 C CB    . VAL C 1 62 ? 2.383   22.061  21.996 1.00 23.87 ? 62  VAL C CB    1 
ATOM   1475 C CG1   . VAL C 1 62 ? 1.689   22.585  20.750 1.00 37.58 ? 62  VAL C CG1   1 
ATOM   1476 C CG2   . VAL C 1 62 ? 3.863   22.424  21.979 1.00 18.15 ? 62  VAL C CG2   1 
ATOM   1477 N N     . VAL C 1 63 ? 2.566   24.456  24.581 1.00 19.57 ? 63  VAL C N     1 
ATOM   1478 C CA    . VAL C 1 63 ? 2.797   25.851  24.945 1.00 20.56 ? 63  VAL C CA    1 
ATOM   1479 C C     . VAL C 1 63 ? 4.299   26.103  24.958 1.00 29.28 ? 63  VAL C C     1 
ATOM   1480 O O     . VAL C 1 63 ? 5.039   25.336  25.585 1.00 9.67  ? 63  VAL C O     1 
ATOM   1481 C CB    . VAL C 1 63 ? 2.177   26.189  26.314 1.00 19.71 ? 63  VAL C CB    1 
ATOM   1482 C CG1   . VAL C 1 63 ? 2.756   25.291  27.400 1.00 33.91 ? 63  VAL C CG1   1 
ATOM   1483 C CG2   . VAL C 1 63 ? 2.395   27.646  26.655 1.00 25.43 ? 63  VAL C CG2   1 
ATOM   1484 N N     . PRO C 1 64 ? 4.789   27.143  24.285 1.00 28.48 ? 64  PRO C N     1 
ATOM   1485 C CA    . PRO C 1 64 ? 6.197   27.520  24.460 1.00 31.65 ? 64  PRO C CA    1 
ATOM   1486 C C     . PRO C 1 64 ? 6.445   28.051  25.864 1.00 21.29 ? 64  PRO C C     1 
ATOM   1487 O O     . PRO C 1 64 ? 5.638   28.803  26.415 1.00 22.34 ? 64  PRO C O     1 
ATOM   1488 C CB    . PRO C 1 64 ? 6.418   28.603  23.395 1.00 26.80 ? 64  PRO C CB    1 
ATOM   1489 C CG    . PRO C 1 64 ? 5.273   28.447  22.435 1.00 36.02 ? 64  PRO C CG    1 
ATOM   1490 C CD    . PRO C 1 64 ? 4.126   27.951  23.247 1.00 33.85 ? 64  PRO C CD    1 
ATOM   1491 N N     . SER C 1 65 ? 7.576   27.644  26.445 1.00 25.69 ? 65  SER C N     1 
ATOM   1492 C CA    . SER C 1 65 ? 7.917   28.079  27.796 1.00 30.35 ? 65  SER C CA    1 
ATOM   1493 C C     . SER C 1 65 ? 8.181   29.578  27.874 1.00 26.95 ? 65  SER C C     1 
ATOM   1494 O O     . SER C 1 65 ? 8.228   30.130  28.979 1.00 19.19 ? 65  SER C O     1 
ATOM   1495 C CB    . SER C 1 65 ? 9.140   27.311  28.299 1.00 34.66 ? 65  SER C CB    1 
ATOM   1496 O OG    . SER C 1 65 ? 10.308  27.725  27.613 1.00 34.68 ? 65  SER C OG    1 
ATOM   1497 N N     . ARG C 1 66 ? 8.348   30.246  26.736 1.00 13.10 ? 66  ARG C N     1 
ATOM   1498 C CA    . ARG C 1 66 ? 8.572   31.683  26.712 1.00 24.46 ? 66  ARG C CA    1 
ATOM   1499 C C     . ARG C 1 66 ? 7.979   32.255  25.435 1.00 33.34 ? 66  ARG C C     1 
ATOM   1500 O O     . ARG C 1 66 ? 7.861   31.538  24.435 1.00 37.57 ? 66  ARG C O     1 
ATOM   1501 C CB    . ARG C 1 66 ? 10.067  32.032  26.788 1.00 25.04 ? 66  ARG C CB    1 
ATOM   1502 C CG    . ARG C 1 66 ? 10.969  31.171  25.916 1.00 37.29 ? 66  ARG C CG    1 
ATOM   1503 C CD    . ARG C 1 66 ? 12.439  31.380  26.281 1.00 49.81 ? 66  ARG C CD    1 
ATOM   1504 N NE    . ARG C 1 66 ? 13.333  30.589  25.443 1.00 37.50 ? 66  ARG C NE    1 
ATOM   1505 C CZ    . ARG C 1 66 ? 14.413  29.954  25.881 1.00 30.41 ? 66  ARG C CZ    1 
ATOM   1506 N NH1   . ARG C 1 66 ? 14.776  29.996  27.153 1.00 48.70 ? 66  ARG C NH1   1 
ATOM   1507 N NH2   . ARG C 1 66 ? 15.149  29.259  25.019 1.00 45.93 ? 66  ARG C NH2   1 
ATOM   1508 N N     . PRO C 1 67 ? 7.597   33.531  25.437 1.00 41.81 ? 67  PRO C N     1 
ATOM   1509 C CA    . PRO C 1 67 ? 7.146   34.166  24.191 1.00 45.32 ? 67  PRO C CA    1 
ATOM   1510 C C     . PRO C 1 67 ? 8.187   33.995  23.096 1.00 59.19 ? 67  PRO C C     1 
ATOM   1511 O O     . PRO C 1 67 ? 9.383   34.208  23.311 1.00 80.09 ? 67  PRO C O     1 
ATOM   1512 C CB    . PRO C 1 67 ? 6.956   35.635  24.587 1.00 41.88 ? 67  PRO C CB    1 
ATOM   1513 C CG    . PRO C 1 67 ? 6.765   35.612  26.061 1.00 40.67 ? 67  PRO C CG    1 
ATOM   1514 C CD    . PRO C 1 67 ? 7.563   34.456  26.583 1.00 27.18 ? 67  PRO C CD    1 
ATOM   1515 N N     . VAL C 1 68 ? 7.727   33.605  21.911 1.00 48.29 ? 68  VAL C N     1 
ATOM   1516 C CA    . VAL C 1 68 ? 8.630   33.058  20.902 1.00 64.02 ? 68  VAL C CA    1 
ATOM   1517 C C     . VAL C 1 68 ? 9.271   34.151  20.047 1.00 88.34 ? 68  VAL C C     1 
ATOM   1518 O O     . VAL C 1 68 ? 10.495  34.174  19.896 1.00 65.45 ? 68  VAL C O     1 
ATOM   1519 C CB    . VAL C 1 68 ? 7.888   32.018  20.032 1.00 39.35 ? 68  VAL C CB    1 
ATOM   1520 C CG1   . VAL C 1 68 ? 8.553   31.882  18.671 1.00 40.97 ? 68  VAL C CG1   1 
ATOM   1521 C CG2   . VAL C 1 68 ? 7.849   30.667  20.739 1.00 29.23 ? 68  VAL C CG2   1 
ATOM   1522 N N     . LEU D 1 7  ? -20.011 -8.020  11.308 1.00 22.29 ? 7   LEU D N     1 
ATOM   1523 C CA    . LEU D 1 7  ? -20.322 -6.630  11.023 1.00 29.26 ? 7   LEU D CA    1 
ATOM   1524 C C     . LEU D 1 7  ? -21.164 -6.030  12.138 1.00 32.52 ? 7   LEU D C     1 
ATOM   1525 O O     . LEU D 1 7  ? -21.698 -6.747  12.985 1.00 44.77 ? 7   LEU D O     1 
ATOM   1526 C CB    . LEU D 1 7  ? -21.066 -6.518  9.700  1.00 22.23 ? 7   LEU D CB    1 
ATOM   1527 C CG    . LEU D 1 7  ? -20.225 -6.509  8.421  1.00 32.63 ? 7   LEU D CG    1 
ATOM   1528 C CD1   . LEU D 1 7  ? -19.763 -5.092  8.117  1.00 38.13 ? 7   LEU D CD1   1 
ATOM   1529 C CD2   . LEU D 1 7  ? -19.019 -7.450  8.489  1.00 35.58 ? 7   LEU D CD2   1 
ATOM   1530 N N     . GLN D 1 8  ? -21.302 -4.707  12.110 1.00 34.08 ? 8   GLN D N     1 
ATOM   1531 C CA    . GLN D 1 8  ? -22.059 -3.988  13.124 1.00 35.37 ? 8   GLN D CA    1 
ATOM   1532 C C     . GLN D 1 8  ? -23.513 -3.779  12.729 1.00 18.39 ? 8   GLN D C     1 
ATOM   1533 O O     . GLN D 1 8  ? -24.373 -3.662  13.608 1.00 6.79  ? 8   GLN D O     1 
ATOM   1534 C CB    . GLN D 1 8  ? -21.389 -2.639  13.399 1.00 25.96 ? 8   GLN D CB    1 
ATOM   1535 C CG    . GLN D 1 8  ? -22.334 -1.482  13.673 1.00 32.43 ? 8   GLN D CG    1 
ATOM   1536 C CD    . GLN D 1 8  ? -21.590 -0.173  13.874 1.00 37.89 ? 8   GLN D CD    1 
ATOM   1537 O OE1   . GLN D 1 8  ? -21.468 0.322   14.993 1.00 22.53 ? 8   GLN D OE1   1 
ATOM   1538 N NE2   . GLN D 1 8  ? -21.086 0.393   12.784 1.00 34.04 ? 8   GLN D NE2   1 
ATOM   1539 N N     . ASP D 1 9  ? -23.795 -3.721  11.422 1.00 15.62 ? 9   ASP D N     1 
ATOM   1540 C CA    . ASP D 1 9  ? -25.193 -3.531  10.985 1.00 22.76 ? 9   ASP D CA    1 
ATOM   1541 C C     . ASP D 1 9  ? -26.017 -4.769  11.257 1.00 41.19 ? 9   ASP D C     1 
ATOM   1542 O O     . ASP D 1 9  ? -27.047 -4.670  11.960 1.00 40.74 ? 9   ASP D O     1 
ATOM   1543 C CB    . ASP D 1 9  ? -25.215 -3.133  9.509  1.00 28.28 ? 9   ASP D CB    1 
ATOM   1544 C CG    . ASP D 1 9  ? -24.810 -1.689  9.286  1.00 29.17 ? 9   ASP D CG    1 
ATOM   1545 O OD1   . ASP D 1 9  ? -24.655 -0.950  10.282 1.00 29.98 ? 9   ASP D OD1   1 
ATOM   1546 O OD2   . ASP D 1 9  ? -24.650 -1.291  8.113  1.00 34.46 ? 9   ASP D OD2   1 
ATOM   1547 N N     . PRO D 1 10 ? -25.674 -5.957  10.753 1.00 23.90 ? 10  PRO D N     1 
ATOM   1548 C CA    . PRO D 1 10 ? -26.461 -7.150  11.092 1.00 26.52 ? 10  PRO D CA    1 
ATOM   1549 C C     . PRO D 1 10 ? -26.579 -7.374  12.588 1.00 30.47 ? 10  PRO D C     1 
ATOM   1550 O O     . PRO D 1 10 ? -27.592 -7.915  13.050 1.00 31.10 ? 10  PRO D O     1 
ATOM   1551 C CB    . PRO D 1 10 ? -25.698 -8.291  10.400 1.00 37.45 ? 10  PRO D CB    1 
ATOM   1552 C CG    . PRO D 1 10 ? -24.334 -7.733  10.108 1.00 33.80 ? 10  PRO D CG    1 
ATOM   1553 C CD    . PRO D 1 10 ? -24.544 -6.274  9.858  1.00 28.85 ? 10  PRO D CD    1 
ATOM   1554 N N     . PHE D 1 11 ? -25.572 -6.964  13.362 1.00 35.77 ? 11  PHE D N     1 
ATOM   1555 C CA    . PHE D 1 11 ? -25.658 -7.066  14.815 1.00 34.92 ? 11  PHE D CA    1 
ATOM   1556 C C     . PHE D 1 11 ? -26.697 -6.097  15.365 1.00 32.58 ? 11  PHE D C     1 
ATOM   1557 O O     . PHE D 1 11 ? -27.612 -6.498  16.092 1.00 24.50 ? 11  PHE D O     1 
ATOM   1558 C CB    . PHE D 1 11 ? -24.283 -6.801  15.431 1.00 28.85 ? 11  PHE D CB    1 
ATOM   1559 C CG    . PHE D 1 11 ? -24.252 -6.907  16.930 1.00 20.77 ? 11  PHE D CG    1 
ATOM   1560 C CD1   . PHE D 1 11 ? -24.523 -5.805  17.725 1.00 18.37 ? 11  PHE D CD1   1 
ATOM   1561 C CD2   . PHE D 1 11 ? -23.944 -8.109  17.544 1.00 24.72 ? 11  PHE D CD2   1 
ATOM   1562 C CE1   . PHE D 1 11 ? -24.490 -5.903  19.104 1.00 13.30 ? 11  PHE D CE1   1 
ATOM   1563 C CE2   . PHE D 1 11 ? -23.911 -8.211  18.922 1.00 18.95 ? 11  PHE D CE2   1 
ATOM   1564 C CZ    . PHE D 1 11 ? -24.184 -7.108  19.702 1.00 15.13 ? 11  PHE D CZ    1 
ATOM   1565 N N     . LEU D 1 12 ? -26.572 -4.813  15.022 1.00 28.54 ? 12  LEU D N     1 
ATOM   1566 C CA    . LEU D 1 12 ? -27.540 -3.825  15.486 1.00 23.78 ? 12  LEU D CA    1 
ATOM   1567 C C     . LEU D 1 12 ? -28.942 -4.147  14.982 1.00 30.95 ? 12  LEU D C     1 
ATOM   1568 O O     . LEU D 1 12 ? -29.919 -4.040  15.733 1.00 25.04 ? 12  LEU D O     1 
ATOM   1569 C CB    . LEU D 1 12 ? -27.117 -2.429  15.027 1.00 33.74 ? 12  LEU D CB    1 
ATOM   1570 C CG    . LEU D 1 12 ? -25.880 -1.820  15.687 1.00 25.37 ? 12  LEU D CG    1 
ATOM   1571 C CD1   . LEU D 1 12 ? -25.372 -0.650  14.858 1.00 23.67 ? 12  LEU D CD1   1 
ATOM   1572 C CD2   . LEU D 1 12 ? -26.187 -1.378  17.106 1.00 10.88 ? 12  LEU D CD2   1 
ATOM   1573 N N     . ASN D 1 13 ? -29.061 -4.544  13.712 1.00 27.86 ? 13  ASN D N     1 
ATOM   1574 C CA    . ASN D 1 13 ? -30.374 -4.836  13.146 1.00 37.96 ? 13  ASN D CA    1 
ATOM   1575 C C     . ASN D 1 13 ? -31.080 -5.938  13.927 1.00 30.94 ? 13  ASN D C     1 
ATOM   1576 O O     . ASN D 1 13 ? -32.285 -5.848  14.191 1.00 33.35 ? 13  ASN D O     1 
ATOM   1577 C CB    . ASN D 1 13 ? -30.233 -5.233  11.676 1.00 41.54 ? 13  ASN D CB    1 
ATOM   1578 C CG    . ASN D 1 13 ? -30.548 -4.090  10.725 1.00 51.71 ? 13  ASN D CG    1 
ATOM   1579 O OD1   . ASN D 1 13 ? -30.945 -3.004  11.145 1.00 50.84 ? 13  ASN D OD1   1 
ATOM   1580 N ND2   . ASN D 1 13 ? -30.369 -4.335  9.432  1.00 50.48 ? 13  ASN D ND2   1 
ATOM   1581 N N     . LEU D 1 15 ? -30.750 -6.827  17.110 1.00 34.52 ? 15  LEU D N     1 
ATOM   1582 C CA    . LEU D 1 15 ? -31.241 -6.258  18.388 1.00 26.49 ? 15  LEU D CA    1 
ATOM   1583 C C     . LEU D 1 15 ? -32.530 -5.485  18.087 1.00 42.06 ? 15  LEU D C     1 
ATOM   1584 O O     . LEU D 1 15 ? -33.544 -5.808  18.711 1.00 33.15 ? 15  LEU D O     1 
ATOM   1585 C CB    . LEU D 1 15 ? -30.121 -5.380  18.924 1.00 36.26 ? 15  LEU D CB    1 
ATOM   1586 C CG    . LEU D 1 15 ? -28.772 -6.062  19.143 1.00 37.99 ? 15  LEU D CG    1 
ATOM   1587 C CD1   . LEU D 1 15 ? -27.884 -5.245  20.068 1.00 43.48 ? 15  LEU D CD1   1 
ATOM   1588 C CD2   . LEU D 1 15 ? -28.954 -7.467  19.682 1.00 47.22 ? 15  LEU D CD2   1 
ATOM   1589 N N     . ARG D 1 16 ? -32.518 -4.600  17.080 1.00 35.24 ? 16  ARG D N     1 
ATOM   1590 C CA    . ARG D 1 16 ? -33.697 -3.791  16.670 1.00 33.71 ? 16  ARG D CA    1 
ATOM   1591 C C     . ARG D 1 16 ? -34.876 -4.720  16.343 1.00 27.15 ? 16  ARG D C     1 
ATOM   1592 O O     . ARG D 1 16 ? -35.949 -4.473  16.872 1.00 24.43 ? 16  ARG D O     1 
ATOM   1593 C CB    . ARG D 1 16 ? -33.332 -2.897  15.485 1.00 27.16 ? 16  ARG D CB    1 
ATOM   1594 C CG    . ARG D 1 16 ? -34.366 -1.841  15.152 1.00 27.39 ? 16  ARG D CG    1 
ATOM   1595 C CD    . ARG D 1 16 ? -34.038 -1.135  13.860 1.00 26.74 ? 16  ARG D CD    1 
ATOM   1596 N NE    . ARG D 1 16 ? -33.970 -2.033  12.724 1.00 31.87 ? 16  ARG D NE    1 
ATOM   1597 C CZ    . ARG D 1 16 ? -33.882 -1.633  11.467 1.00 45.53 ? 16  ARG D CZ    1 
ATOM   1598 N NH1   . ARG D 1 16 ? -34.066 -0.360  11.170 1.00 45.54 ? 16  ARG D NH1   1 
ATOM   1599 N NH2   . ARG D 1 16 ? -33.617 -2.505  10.512 1.00 49.74 ? 16  ARG D NH2   1 
ATOM   1600 N N     . ARG D 1 17 ? -34.675 -5.764  15.533 1.00 30.89 ? 17  ARG D N     1 
ATOM   1601 C CA    . ARG D 1 17 ? -35.766 -6.667  15.180 1.00 25.86 ? 17  ARG D CA    1 
ATOM   1602 C C     . ARG D 1 17 ? -36.324 -7.358  16.419 1.00 30.43 ? 17  ARG D C     1 
ATOM   1603 O O     . ARG D 1 17 ? -37.503 -7.205  16.759 1.00 33.85 ? 17  ARG D O     1 
ATOM   1604 C CB    . ARG D 1 17 ? -35.281 -7.705  14.164 1.00 35.35 ? 17  ARG D CB    1 
ATOM   1605 C CG    . ARG D 1 17 ? -35.134 -7.183  12.739 1.00 37.44 ? 17  ARG D CG    1 
ATOM   1606 C CD    . ARG D 1 17 ? -34.407 -8.178  11.830 1.00 65.95 ? 17  ARG D CD    1 
ATOM   1607 N NE    . ARG D 1 17 ? -33.513 -9.071  12.560 1.00 58.98 ? 17  ARG D NE    1 
ATOM   1608 C CZ    . ARG D 1 17 ? -33.857 -10.253 13.056 1.00 58.87 ? 17  ARG D CZ    1 
ATOM   1609 N NH1   . ARG D 1 17 ? -35.083 -10.734 12.919 1.00 50.17 ? 17  ARG D NH1   1 
ATOM   1610 N NH2   . ARG D 1 17 ? -32.947 -10.972 13.708 1.00 40.43 ? 17  ARG D NH2   1 
ATOM   1611 N N     . GLU D 1 18 ? -35.481 -8.128  17.111 1.00 20.43 ? 18  GLU D N     1 
ATOM   1612 C CA    . GLU D 1 18 ? -35.935 -8.927  18.242 1.00 30.36 ? 18  GLU D CA    1 
ATOM   1613 C C     . GLU D 1 18 ? -36.379 -8.085  19.430 1.00 26.05 ? 18  GLU D C     1 
ATOM   1614 O O     . GLU D 1 18 ? -36.898 -8.646  20.400 1.00 22.63 ? 18  GLU D O     1 
ATOM   1615 C CB    . GLU D 1 18 ? -34.826 -9.885  18.682 1.00 33.45 ? 18  GLU D CB    1 
ATOM   1616 C CG    . GLU D 1 18 ? -35.037 -11.327 18.244 1.00 45.33 ? 18  GLU D CG    1 
ATOM   1617 C CD    . GLU D 1 18 ? -35.296 -11.455 16.755 1.00 52.08 ? 18  GLU D CD    1 
ATOM   1618 O OE1   . GLU D 1 18 ? -36.361 -11.989 16.379 1.00 51.56 ? 18  GLU D OE1   1 
ATOM   1619 O OE2   . GLU D 1 18 ? -34.437 -11.018 15.959 1.00 56.73 ? 18  GLU D OE2   1 
ATOM   1620 N N     . ARG D 1 19 ? -36.195 -6.752  19.392 1.00 29.71 ? 19  ARG D N     1 
ATOM   1621 C CA    . ARG D 1 19 ? -36.654 -5.813  20.458 1.00 18.09 ? 19  ARG D CA    1 
ATOM   1622 C C     . ARG D 1 19 ? -36.043 -6.200  21.806 1.00 15.85 ? 19  ARG D C     1 
ATOM   1623 O O     . ARG D 1 19 ? -36.683 -6.029  22.819 1.00 13.26 ? 19  ARG D O     1 
ATOM   1624 C CB    . ARG D 1 19 ? -38.186 -5.812  20.537 1.00 31.88 ? 19  ARG D CB    1 
ATOM   1625 C CG    . ARG D 1 19 ? -38.810 -4.453  20.808 1.00 26.49 ? 19  ARG D CG    1 
ATOM   1626 C CD    . ARG D 1 19 ? -38.957 -3.544  19.601 1.00 30.33 ? 19  ARG D CD    1 
ATOM   1627 N NE    . ARG D 1 19 ? -38.561 -4.128  18.332 1.00 33.11 ? 19  ARG D NE    1 
ATOM   1628 C CZ    . ARG D 1 19 ? -39.148 -3.871  17.173 1.00 35.03 ? 19  ARG D CZ    1 
ATOM   1629 N NH1   . ARG D 1 19 ? -39.726 -2.704  16.969 1.00 28.44 ? 19  ARG D NH1   1 
ATOM   1630 N NH2   . ARG D 1 19 ? -39.118 -4.766  16.203 1.00 36.57 ? 19  ARG D NH2   1 
ATOM   1631 N N     . VAL D 1 20 ? -34.806 -6.681  21.800 1.00 33.81 ? 20  VAL D N     1 
ATOM   1632 C CA    . VAL D 1 20 ? -34.078 -7.077  23.038 1.00 19.39 ? 20  VAL D CA    1 
ATOM   1633 C C     . VAL D 1 20 ? -33.675 -5.823  23.797 1.00 15.89 ? 20  VAL D C     1 
ATOM   1634 O O     . VAL D 1 20 ? -33.280 -4.888  23.225 1.00 16.86 ? 20  VAL D O     1 
ATOM   1635 C CB    . VAL D 1 20 ? -32.844 -7.931  22.724 1.00 32.60 ? 20  VAL D CB    1 
ATOM   1636 C CG1   . VAL D 1 20 ? -32.309 -8.636  23.962 1.00 29.80 ? 20  VAL D CG1   1 
ATOM   1637 C CG2   . VAL D 1 20 ? -33.116 -8.935  21.615 1.00 35.49 ? 20  VAL D CG2   1 
ATOM   1638 N N     . PRO D 1 21 ? -33.772 -5.771  25.127 1.00 25.80 ? 21  PRO D N     1 
ATOM   1639 C CA    . PRO D 1 21 ? -33.241 -4.614  25.830 1.00 15.18 ? 21  PRO D CA    1 
ATOM   1640 C C     . PRO D 1 21 ? -31.715 -4.694  25.715 1.00 22.43 ? 21  PRO D C     1 
ATOM   1641 O O     . PRO D 1 21 ? -31.204 -5.776  25.778 1.00 25.66 ? 21  PRO D O     1 
ATOM   1642 C CB    . PRO D 1 21 ? -33.761 -4.766  27.251 1.00 17.74 ? 21  PRO D CB    1 
ATOM   1643 C CG    . PRO D 1 21 ? -34.124 -6.230  27.391 1.00 20.16 ? 21  PRO D CG    1 
ATOM   1644 C CD    . PRO D 1 21 ? -34.407 -6.747  25.995 1.00 15.06 ? 21  PRO D CD    1 
ATOM   1645 N N     . ALA D 1 22 ? -31.034 -3.560  25.573 1.00 23.77 ? 22  ALA D N     1 
ATOM   1646 C CA    . ALA D 1 22 ? -29.571 -3.524  25.373 1.00 19.20 ? 22  ALA D CA    1 
ATOM   1647 C C     . ALA D 1 22 ? -28.884 -2.454  26.218 1.00 9.51  ? 22  ALA D C     1 
ATOM   1648 O O     . ALA D 1 22 ? -29.525 -1.445  26.498 1.00 17.57 ? 22  ALA D O     1 
ATOM   1649 C CB    . ALA D 1 22 ? -29.259 -3.333  23.909 1.00 30.00 ? 22  ALA D CB    1 
ATOM   1650 N N     . SER D 1 23 ? -27.653 -2.721  26.645 1.00 13.08 ? 23  SER D N     1 
ATOM   1651 C CA    . SER D 1 23 ? -26.800 -1.742  27.352 1.00 18.01 ? 23  SER D CA    1 
ATOM   1652 C C     . SER D 1 23 ? -25.743 -1.236  26.366 1.00 27.33 ? 23  SER D C     1 
ATOM   1653 O O     . SER D 1 23 ? -25.286 -2.046  25.547 1.00 24.13 ? 23  SER D O     1 
ATOM   1654 C CB    . SER D 1 23 ? -26.175 -2.323  28.577 1.00 13.44 ? 23  SER D CB    1 
ATOM   1655 O OG    . SER D 1 23 ? -27.135 -2.955  29.402 1.00 22.04 ? 23  SER D OG    1 
ATOM   1656 N N     . ILE D 1 24 ? -25.434 0.058   26.387 1.00 22.35 ? 24  ILE D N     1 
ATOM   1657 C CA    . ILE D 1 24 ? -24.389 0.667   25.528 1.00 15.06 ? 24  ILE D CA    1 
ATOM   1658 C C     . ILE D 1 24 ? -23.410 1.302   26.508 1.00 10.39 ? 24  ILE D C     1 
ATOM   1659 O O     . ILE D 1 24 ? -23.765 2.326   27.088 1.00 22.57 ? 24  ILE D O     1 
ATOM   1660 C CB    . ILE D 1 24 ? -24.971 1.658   24.503 1.00 17.81 ? 24  ILE D CB    1 
ATOM   1661 C CG1   . ILE D 1 24 ? -25.724 0.935   23.389 1.00 16.24 ? 24  ILE D CG1   1 
ATOM   1662 C CG2   . ILE D 1 24 ? -23.891 2.573   23.954 1.00 11.71 ? 24  ILE D CG2   1 
ATOM   1663 C CD1   . ILE D 1 24 ? -26.821 1.758   22.774 1.00 12.64 ? 24  ILE D CD1   1 
ATOM   1664 N N     . TYR D 1 25 ? -22.283 0.649   26.760 1.00 12.52 ? 25  TYR D N     1 
ATOM   1665 C CA    . TYR D 1 25 ? -21.247 1.185   27.670 1.00 23.78 ? 25  TYR D CA    1 
ATOM   1666 C C     . TYR D 1 25 ? -20.503 2.282   26.905 1.00 24.77 ? 25  TYR D C     1 
ATOM   1667 O O     . TYR D 1 25 ? -20.184 2.027   25.734 1.00 10.98 ? 25  TYR D O     1 
ATOM   1668 C CB    . TYR D 1 25 ? -20.322 0.088   28.182 1.00 14.97 ? 25  TYR D CB    1 
ATOM   1669 C CG    . TYR D 1 25 ? -20.979 -0.914  29.080 1.00 9.35  ? 25  TYR D CG    1 
ATOM   1670 C CD1   . TYR D 1 25 ? -21.713 -1.971  28.573 1.00 15.55 ? 25  TYR D CD1   1 
ATOM   1671 C CD2   . TYR D 1 25 ? -20.853 -0.793  30.444 1.00 9.89  ? 25  TYR D CD2   1 
ATOM   1672 C CE1   . TYR D 1 25 ? -22.315 -2.890  29.413 1.00 7.82  ? 25  TYR D CE1   1 
ATOM   1673 C CE2   . TYR D 1 25 ? -21.437 -1.703  31.294 1.00 11.69 ? 25  TYR D CE2   1 
ATOM   1674 C CZ    . TYR D 1 25 ? -22.174 -2.754  30.782 1.00 13.41 ? 25  TYR D CZ    1 
ATOM   1675 O OH    . TYR D 1 25 ? -22.757 -3.656  31.619 1.00 7.94  ? 25  TYR D OH    1 
ATOM   1676 N N     . LEU D 1 26 ? -20.366 3.462   27.488 1.00 10.69 ? 26  LEU D N     1 
ATOM   1677 C CA    . LEU D 1 26 ? -19.614 4.556   26.896 1.00 17.11 ? 26  LEU D CA    1 
ATOM   1678 C C     . LEU D 1 26 ? -18.133 4.432   27.242 1.00 14.43 ? 26  LEU D C     1 
ATOM   1679 O O     . LEU D 1 26 ? -17.741 3.707   28.159 1.00 10.25 ? 26  LEU D O     1 
ATOM   1680 C CB    . LEU D 1 26 ? -20.150 5.907   27.370 1.00 23.51 ? 26  LEU D CB    1 
ATOM   1681 C CG    . LEU D 1 26 ? -21.634 6.175   27.121 1.00 16.82 ? 26  LEU D CG    1 
ATOM   1682 C CD1   . LEU D 1 26 ? -22.029 7.549   27.646 1.00 7.38  ? 26  LEU D CD1   1 
ATOM   1683 C CD2   . LEU D 1 26 ? -21.960 6.048   25.640 1.00 20.91 ? 26  LEU D CD2   1 
ATOM   1684 N N     . VAL D 1 27 ? -17.306 5.165   26.494 1.00 10.16 ? 27  VAL D N     1 
ATOM   1685 C CA    . VAL D 1 27 ? -15.868 5.141   26.716 1.00 4.97  ? 27  VAL D CA    1 
ATOM   1686 C C     . VAL D 1 27 ? -15.481 5.661   28.093 1.00 3.51  ? 27  VAL D C     1 
ATOM   1687 O O     . VAL D 1 27 ? -14.322 5.525   28.494 1.00 3.76  ? 27  VAL D O     1 
ATOM   1688 C CB    . VAL D 1 27 ? -15.134 5.958   25.628 1.00 2.51  ? 27  VAL D CB    1 
ATOM   1689 C CG1   . VAL D 1 27 ? -15.251 5.270   24.284 1.00 2.11  ? 27  VAL D CG1   1 
ATOM   1690 C CG2   . VAL D 1 27 ? -15.687 7.375   25.558 1.00 2.84  ? 27  VAL D CG2   1 
ATOM   1691 N N     . ASN D 1 28 ? -16.419 6.259   28.823 1.00 3.36  ? 28  ASN D N     1 
ATOM   1692 C CA    . ASN D 1 28 ? -16.171 6.757   30.167 1.00 14.22 ? 28  ASN D CA    1 
ATOM   1693 C C     . ASN D 1 28 ? -16.764 5.851   31.240 1.00 10.67 ? 28  ASN D C     1 
ATOM   1694 O O     . ASN D 1 28 ? -16.750 6.211   32.422 1.00 7.32  ? 28  ASN D O     1 
ATOM   1695 C CB    . ASN D 1 28 ? -16.722 8.178   30.310 1.00 15.90 ? 28  ASN D CB    1 
ATOM   1696 C CG    . ASN D 1 28 ? -18.097 8.339   29.688 1.00 19.47 ? 28  ASN D CG    1 
ATOM   1697 O OD1   . ASN D 1 28 ? -19.111 8.243   30.372 1.00 17.61 ? 28  ASN D OD1   1 
ATOM   1698 N ND2   . ASN D 1 28 ? -18.134 8.589   28.384 1.00 16.81 ? 28  ASN D ND2   1 
ATOM   1699 N N     . GLY D 1 29 ? -17.280 4.684   30.855 1.00 17.46 ? 29  GLY D N     1 
ATOM   1700 C CA    . GLY D 1 29 ? -17.805 3.722   31.797 1.00 16.45 ? 29  GLY D CA    1 
ATOM   1701 C C     . GLY D 1 29 ? -19.292 3.812   32.057 1.00 22.36 ? 29  GLY D C     1 
ATOM   1702 O O     . GLY D 1 29 ? -19.842 2.921   32.720 1.00 2.66  ? 29  GLY D O     1 
ATOM   1703 N N     . ILE D 1 30 ? -19.961 4.851   31.558 1.00 14.27 ? 30  ILE D N     1 
ATOM   1704 C CA    . ILE D 1 30 ? -21.384 5.025   31.816 1.00 17.84 ? 30  ILE D CA    1 
ATOM   1705 C C     . ILE D 1 30 ? -22.171 3.962   31.064 1.00 8.99  ? 30  ILE D C     1 
ATOM   1706 O O     . ILE D 1 30 ? -21.973 3.754   29.860 1.00 8.89  ? 30  ILE D O     1 
ATOM   1707 C CB    . ILE D 1 30 ? -21.831 6.437   31.408 1.00 14.53 ? 30  ILE D CB    1 
ATOM   1708 C CG1   . ILE D 1 30 ? -21.156 7.481   32.299 1.00 17.20 ? 30  ILE D CG1   1 
ATOM   1709 C CG2   . ILE D 1 30 ? -23.350 6.550   31.463 1.00 24.92 ? 30  ILE D CG2   1 
ATOM   1710 C CD1   . ILE D 1 30 ? -21.493 7.346   33.754 1.00 30.26 ? 30  ILE D CD1   1 
ATOM   1711 N N     . LYS D 1 31 ? -23.067 3.254   31.752 1.00 10.85 ? 31  LYS D N     1 
ATOM   1712 C CA    . LYS D 1 31 ? -23.937 2.255   31.070 1.00 12.60 ? 31  LYS D CA    1 
ATOM   1713 C C     . LYS D 1 31 ? -25.299 2.871   30.770 1.00 20.23 ? 31  LYS D C     1 
ATOM   1714 O O     . LYS D 1 31 ? -25.929 3.422   31.679 1.00 15.76 ? 31  LYS D O     1 
ATOM   1715 C CB    . LYS D 1 31 ? -24.139 0.958   31.837 1.00 29.76 ? 31  LYS D CB    1 
ATOM   1716 C CG    . LYS D 1 31 ? -24.938 -0.118  31.123 1.00 20.63 ? 31  LYS D CG    1 
ATOM   1717 C CD    . LYS D 1 31 ? -25.850 -0.859  32.052 1.00 21.53 ? 31  LYS D CD    1 
ATOM   1718 C CE    . LYS D 1 31 ? -25.122 -1.918  32.843 1.00 31.83 ? 31  LYS D CE    1 
ATOM   1719 N NZ    . LYS D 1 31 ? -25.989 -2.545  33.865 1.00 25.38 ? 31  LYS D NZ    1 
ATOM   1720 N N     . LEU D 1 32 ? -25.684 2.820   29.511 1.00 16.62 ? 32  LEU D N     1 
ATOM   1721 C CA    . LEU D 1 32 ? -26.994 3.319   29.069 1.00 21.10 ? 32  LEU D CA    1 
ATOM   1722 C C     . LEU D 1 32 ? -27.871 2.127   28.662 1.00 25.22 ? 32  LEU D C     1 
ATOM   1723 O O     . LEU D 1 32 ? -27.575 1.497   27.654 1.00 17.68 ? 32  LEU D O     1 
ATOM   1724 C CB    . LEU D 1 32 ? -26.761 4.298   27.922 1.00 20.85 ? 32  LEU D CB    1 
ATOM   1725 C CG    . LEU D 1 32 ? -26.007 5.577   28.283 1.00 26.16 ? 32  LEU D CG    1 
ATOM   1726 C CD1   . LEU D 1 32 ? -26.230 6.641   27.223 1.00 16.74 ? 32  LEU D CD1   1 
ATOM   1727 C CD2   . LEU D 1 32 ? -26.408 6.104   29.654 1.00 13.87 ? 32  LEU D CD2   1 
ATOM   1728 N N     . GLN D 1 33 ? -28.916 1.854   29.429 1.00 26.23 ? 33  GLN D N     1 
ATOM   1729 C CA    . GLN D 1 33 ? -29.883 0.762   29.125 1.00 33.29 ? 33  GLN D CA    1 
ATOM   1730 C C     . GLN D 1 33 ? -31.070 1.351   28.368 1.00 23.25 ? 33  GLN D C     1 
ATOM   1731 O O     . GLN D 1 33 ? -31.532 2.381   28.758 1.00 24.13 ? 33  GLN D O     1 
ATOM   1732 C CB    . GLN D 1 33 ? -30.307 0.061   30.415 1.00 14.12 ? 33  GLN D CB    1 
ATOM   1733 C CG    . GLN D 1 33 ? -29.163 -0.650  31.110 1.00 18.03 ? 33  GLN D CG    1 
ATOM   1734 C CD    . GLN D 1 33 ? -29.513 -0.925  32.548 1.00 23.26 ? 33  GLN D CD    1 
ATOM   1735 O OE1   . GLN D 1 33 ? -29.218 -0.144  33.445 1.00 23.21 ? 33  GLN D OE1   1 
ATOM   1736 N NE2   . GLN D 1 33 ? -30.179 -2.043  32.767 1.00 39.79 ? 33  GLN D NE2   1 
ATOM   1737 N N     . GLY D 1 34 ? -31.434 0.776   27.244 1.00 35.83 ? 34  GLY D N     1 
ATOM   1738 C CA    . GLY D 1 34 ? -32.607 1.182   26.463 1.00 21.55 ? 34  GLY D CA    1 
ATOM   1739 C C     . GLY D 1 34 ? -32.887 0.151   25.411 1.00 16.49 ? 34  GLY D C     1 
ATOM   1740 O O     . GLY D 1 34 ? -32.574 -1.015  25.651 1.00 24.48 ? 34  GLY D O     1 
ATOM   1741 N N     . GLN D 1 35 ? -33.427 0.578   24.286 1.00 21.83 ? 35  GLN D N     1 
ATOM   1742 C CA    . GLN D 1 35 ? -33.646 -0.315  23.133 1.00 30.24 ? 35  GLN D CA    1 
ATOM   1743 C C     . GLN D 1 35 ? -33.164 0.355   21.844 1.00 25.11 ? 35  GLN D C     1 
ATOM   1744 O O     . GLN D 1 35 ? -33.528 1.507   21.617 1.00 18.80 ? 35  GLN D O     1 
ATOM   1745 C CB    . GLN D 1 35 ? -35.122 -0.719  23.005 1.00 39.84 ? 35  GLN D CB    1 
ATOM   1746 C CG    . GLN D 1 35 ? -35.577 -1.700  24.073 1.00 29.91 ? 35  GLN D CG    1 
ATOM   1747 C CD    . GLN D 1 35 ? -36.009 -3.040  23.534 1.00 33.97 ? 35  GLN D CD    1 
ATOM   1748 O OE1   . GLN D 1 35 ? -36.150 -3.242  22.332 1.00 25.83 ? 35  GLN D OE1   1 
ATOM   1749 N NE2   . GLN D 1 35 ? -36.211 -3.978  24.442 1.00 35.30 ? 35  GLN D NE2   1 
ATOM   1750 N N     . ILE D 1 36 ? -32.388 -0.364  21.034 1.00 34.16 ? 36  ILE D N     1 
ATOM   1751 C CA    . ILE D 1 36 ? -31.874 0.145   19.734 1.00 27.93 ? 36  ILE D CA    1 
ATOM   1752 C C     . ILE D 1 36 ? -33.093 0.421   18.871 1.00 25.74 ? 36  ILE D C     1 
ATOM   1753 O O     . ILE D 1 36 ? -33.715 -0.541  18.413 1.00 28.89 ? 36  ILE D O     1 
ATOM   1754 C CB    . ILE D 1 36 ? -30.869 -0.822  19.070 1.00 17.62 ? 36  ILE D CB    1 
ATOM   1755 C CG1   . ILE D 1 36 ? -29.566 -0.915  19.862 1.00 27.84 ? 36  ILE D CG1   1 
ATOM   1756 C CG2   . ILE D 1 36 ? -30.604 -0.419  17.631 1.00 31.10 ? 36  ILE D CG2   1 
ATOM   1757 C CD1   . ILE D 1 36 ? -28.821 -2.206  19.658 1.00 29.68 ? 36  ILE D CD1   1 
ATOM   1758 N N     . GLU D 1 37 ? -33.398 1.690   18.666 1.00 22.94 ? 37  GLU D N     1 
ATOM   1759 C CA    . GLU D 1 37 ? -34.574 2.104   17.892 1.00 11.59 ? 37  GLU D CA    1 
ATOM   1760 C C     . GLU D 1 37 ? -34.141 2.204   16.446 1.00 18.00 ? 37  GLU D C     1 
ATOM   1761 O O     . GLU D 1 37 ? -34.787 1.562   15.730 1.00 15.55 ? 37  GLU D O     1 
ATOM   1762 C CB    . GLU D 1 37 ? -35.109 3.442   18.351 1.00 27.18 ? 37  GLU D CB    1 
ATOM   1763 C CG    . GLU D 1 37 ? -36.365 3.351   19.180 1.00 38.01 ? 37  GLU D CG    1 
ATOM   1764 C CD    . GLU D 1 37 ? -36.999 4.708   19.416 1.00 46.37 ? 37  GLU D CD    1 
ATOM   1765 O OE1   . GLU D 1 37 ? -36.473 5.700   18.879 1.00 40.51 ? 37  GLU D OE1   1 
ATOM   1766 O OE2   . GLU D 1 37 ? -38.009 4.764   20.130 1.00 55.04 ? 37  GLU D OE2   1 
ATOM   1767 N N     . SER D 1 38 ? -33.005 2.839   16.150 1.00 17.46 ? 38  SER D N     1 
ATOM   1768 C CA    . SER D 1 38 ? -32.499 3.067   14.775 1.00 30.45 ? 38  SER D CA    1 
ATOM   1769 C C     . SER D 1 38 ? -30.980 3.294   14.768 1.00 28.23 ? 38  SER D C     1 
ATOM   1770 O O     . SER D 1 38 ? -30.411 3.389   15.833 1.00 21.12 ? 38  SER D O     1 
ATOM   1771 C CB    . SER D 1 38 ? -33.199 4.227   14.142 1.00 16.74 ? 38  SER D CB    1 
ATOM   1772 O OG    . SER D 1 38 ? -33.309 5.310   15.050 1.00 43.84 ? 38  SER D OG    1 
ATOM   1773 N N     . PHE D 1 39 ? -30.352 3.255   13.597 1.00 23.69 ? 39  PHE D N     1 
ATOM   1774 C CA    . PHE D 1 39 ? -28.902 3.558   13.487 1.00 27.74 ? 39  PHE D CA    1 
ATOM   1775 C C     . PHE D 1 39 ? -28.556 3.959   12.057 1.00 24.64 ? 39  PHE D C     1 
ATOM   1776 O O     . PHE D 1 39 ? -29.324 3.686   11.122 1.00 14.03 ? 39  PHE D O     1 
ATOM   1777 C CB    . PHE D 1 39 ? -27.989 2.403   13.914 1.00 23.49 ? 39  PHE D CB    1 
ATOM   1778 C CG    . PHE D 1 39 ? -28.202 1.099   13.166 1.00 21.69 ? 39  PHE D CG    1 
ATOM   1779 C CD1   . PHE D 1 39 ? -27.522 0.844   11.985 1.00 26.97 ? 39  PHE D CD1   1 
ATOM   1780 C CD2   . PHE D 1 39 ? -29.068 0.130   13.654 1.00 24.57 ? 39  PHE D CD2   1 
ATOM   1781 C CE1   . PHE D 1 39 ? -27.707 -0.346  11.308 1.00 30.09 ? 39  PHE D CE1   1 
ATOM   1782 C CE2   . PHE D 1 39 ? -29.254 -1.057  12.968 1.00 26.95 ? 39  PHE D CE2   1 
ATOM   1783 C CZ    . PHE D 1 39 ? -28.569 -1.293  11.800 1.00 33.95 ? 39  PHE D CZ    1 
ATOM   1784 N N     . ASP D 1 40 ? -27.417 4.633   11.914 1.00 29.09 ? 40  ASP D N     1 
ATOM   1785 C CA    . ASP D 1 40 ? -26.899 5.024   10.581 1.00 19.70 ? 40  ASP D CA    1 
ATOM   1786 C C     . ASP D 1 40 ? -25.376 4.960   10.699 1.00 24.39 ? 40  ASP D C     1 
ATOM   1787 O O     . ASP D 1 40 ? -24.909 4.390   11.698 1.00 34.32 ? 40  ASP D O     1 
ATOM   1788 C CB    . ASP D 1 40 ? -27.544 6.325   10.139 1.00 34.30 ? 40  ASP D CB    1 
ATOM   1789 C CG    . ASP D 1 40 ? -26.768 7.589   10.464 1.00 39.18 ? 40  ASP D CG    1 
ATOM   1790 O OD1   . ASP D 1 40 ? -26.485 7.796   11.648 1.00 37.84 ? 40  ASP D OD1   1 
ATOM   1791 O OD2   . ASP D 1 40 ? -26.437 8.328   9.520  1.00 46.85 ? 40  ASP D OD2   1 
ATOM   1792 N N     . GLN D 1 41 ? -24.628 5.585   9.803  1.00 31.96 ? 41  GLN D N     1 
ATOM   1793 C CA    . GLN D 1 41 ? -23.176 5.461   9.746  1.00 32.63 ? 41  GLN D CA    1 
ATOM   1794 C C     . GLN D 1 41 ? -22.514 5.900   11.047 1.00 24.29 ? 41  GLN D C     1 
ATOM   1795 O O     . GLN D 1 41 ? -21.495 5.330   11.452 1.00 21.39 ? 41  GLN D O     1 
ATOM   1796 C CB    . GLN D 1 41 ? -22.627 6.277   8.576  1.00 38.66 ? 41  GLN D CB    1 
ATOM   1797 C CG    . GLN D 1 41 ? -21.404 5.668   7.908  1.00 43.40 ? 41  GLN D CG    1 
ATOM   1798 C CD    . GLN D 1 41 ? -20.513 6.714   7.267  1.00 33.44 ? 41  GLN D CD    1 
ATOM   1799 O OE1   . GLN D 1 41 ? -20.993 7.730   6.765  1.00 60.08 ? 41  GLN D OE1   1 
ATOM   1800 N NE2   . GLN D 1 41 ? -19.208 6.470   7.281  1.00 39.55 ? 41  GLN D NE2   1 
ATOM   1801 N N     . PHE D 1 42 ? -23.072 6.906   11.717 1.00 27.68 ? 42  PHE D N     1 
ATOM   1802 C CA    . PHE D 1 42 ? -22.380 7.542   12.828 1.00 9.88  ? 42  PHE D CA    1 
ATOM   1803 C C     . PHE D 1 42 ? -23.061 7.395   14.179 1.00 9.05  ? 42  PHE D C     1 
ATOM   1804 O O     . PHE D 1 42 ? -22.372 7.476   15.200 1.00 6.60  ? 42  PHE D O     1 
ATOM   1805 C CB    . PHE D 1 42 ? -22.191 9.044   12.551 1.00 21.34 ? 42  PHE D CB    1 
ATOM   1806 C CG    . PHE D 1 42 ? -21.387 9.334   11.321 1.00 25.10 ? 42  PHE D CG    1 
ATOM   1807 C CD1   . PHE D 1 42 ? -20.007 9.430   11.386 1.00 26.83 ? 42  PHE D CD1   1 
ATOM   1808 C CD2   . PHE D 1 42 ? -22.010 9.512   10.100 1.00 37.05 ? 42  PHE D CD2   1 
ATOM   1809 C CE1   . PHE D 1 42 ? -19.264 9.696   10.251 1.00 49.23 ? 42  PHE D CE1   1 
ATOM   1810 C CE2   . PHE D 1 42 ? -21.273 9.777   8.962  1.00 42.41 ? 42  PHE D CE2   1 
ATOM   1811 C CZ    . PHE D 1 42 ? -19.899 9.871   9.037  1.00 41.18 ? 42  PHE D CZ    1 
ATOM   1812 N N     . VAL D 1 43 ? -24.379 7.194   14.233 1.00 21.85 ? 43  VAL D N     1 
ATOM   1813 C CA    . VAL D 1 43 ? -25.093 7.247   15.502 1.00 19.13 ? 43  VAL D CA    1 
ATOM   1814 C C     . VAL D 1 43 ? -26.089 6.102   15.612 1.00 21.97 ? 43  VAL D C     1 
ATOM   1815 O O     . VAL D 1 43 ? -26.473 5.472   14.624 1.00 10.84 ? 43  VAL D O     1 
ATOM   1816 C CB    . VAL D 1 43 ? -25.840 8.589   15.699 1.00 9.50  ? 43  VAL D CB    1 
ATOM   1817 C CG1   . VAL D 1 43 ? -24.921 9.768   15.393 1.00 11.72 ? 43  VAL D CG1   1 
ATOM   1818 C CG2   . VAL D 1 43 ? -27.109 8.620   14.852 1.00 21.86 ? 43  VAL D CG2   1 
ATOM   1819 N N     . ILE D 1 44 ? -26.504 5.849   16.851 1.00 20.51 ? 44  ILE D N     1 
ATOM   1820 C CA    . ILE D 1 44 ? -27.578 4.919   17.173 1.00 25.35 ? 44  ILE D CA    1 
ATOM   1821 C C     . ILE D 1 44 ? -28.548 5.641   18.098 1.00 21.83 ? 44  ILE D C     1 
ATOM   1822 O O     . ILE D 1 44 ? -28.123 6.303   19.051 1.00 8.38  ? 44  ILE D O     1 
ATOM   1823 C CB    . ILE D 1 44 ? -27.054 3.637   17.848 1.00 26.05 ? 44  ILE D CB    1 
ATOM   1824 C CG1   . ILE D 1 44 ? -25.992 2.959   16.982 1.00 16.15 ? 44  ILE D CG1   1 
ATOM   1825 C CG2   . ILE D 1 44 ? -28.207 2.679   18.124 1.00 18.40 ? 44  ILE D CG2   1 
ATOM   1826 C CD1   . ILE D 1 44 ? -24.967 2.192   17.789 1.00 19.70 ? 44  ILE D CD1   1 
ATOM   1827 N N     . LEU D 1 45 ? -29.843 5.552   17.805 1.00 21.01 ? 45  LEU D N     1 
ATOM   1828 C CA    . LEU D 1 45 ? -30.876 6.147   18.684 1.00 28.72 ? 45  LEU D CA    1 
ATOM   1829 C C     . LEU D 1 45 ? -31.354 5.078   19.671 1.00 22.29 ? 45  LEU D C     1 
ATOM   1830 O O     . LEU D 1 45 ? -31.807 4.016   19.227 1.00 12.62 ? 45  LEU D O     1 
ATOM   1831 C CB    . LEU D 1 45 ? -32.026 6.711   17.855 1.00 31.71 ? 45  LEU D CB    1 
ATOM   1832 C CG    . LEU D 1 45 ? -31.863 8.170   17.440 1.00 34.09 ? 45  LEU D CG    1 
ATOM   1833 C CD1   . LEU D 1 45 ? -30.576 8.366   16.661 1.00 37.00 ? 45  LEU D CD1   1 
ATOM   1834 C CD2   . LEU D 1 45 ? -33.056 8.631   16.625 1.00 27.69 ? 45  LEU D CD2   1 
ATOM   1835 N N     . LEU D 1 46 ? -31.200 5.352   20.953 1.00 23.27 ? 46  LEU D N     1 
ATOM   1836 C CA    . LEU D 1 46 ? -31.616 4.431   22.038 1.00 32.03 ? 46  LEU D CA    1 
ATOM   1837 C C     . LEU D 1 46 ? -32.923 4.945   22.670 1.00 29.29 ? 46  LEU D C     1 
ATOM   1838 O O     . LEU D 1 46 ? -32.990 6.125   22.916 1.00 17.94 ? 46  LEU D O     1 
ATOM   1839 C CB    . LEU D 1 46 ? -30.472 4.379   23.058 1.00 15.95 ? 46  LEU D CB    1 
ATOM   1840 C CG    . LEU D 1 46 ? -30.735 3.517   24.292 1.00 27.63 ? 46  LEU D CG    1 
ATOM   1841 C CD1   . LEU D 1 46 ? -30.533 2.044   23.980 1.00 12.64 ? 46  LEU D CD1   1 
ATOM   1842 C CD2   . LEU D 1 46 ? -29.865 3.946   25.460 1.00 13.72 ? 46  LEU D CD2   1 
ATOM   1843 N N     . LYS D 1 47 ? -33.884 4.082   22.986 1.00 25.78 ? 47  LYS D N     1 
ATOM   1844 C CA    . LYS D 1 47 ? -35.186 4.487   23.581 1.00 21.62 ? 47  LYS D CA    1 
ATOM   1845 C C     . LYS D 1 47 ? -35.373 4.006   25.031 1.00 10.57 ? 47  LYS D C     1 
ATOM   1846 O O     . LYS D 1 47 ? -35.018 2.880   25.312 1.00 15.43 ? 47  LYS D O     1 
ATOM   1847 C CB    . LYS D 1 47 ? -36.295 3.970   22.680 1.00 20.58 ? 47  LYS D CB    1 
ATOM   1848 C CG    . LYS D 1 47 ? -37.680 4.487   23.043 1.00 39.82 ? 47  LYS D CG    1 
ATOM   1849 C CD    . LYS D 1 47 ? -37.826 5.988   22.937 1.00 50.96 ? 47  LYS D CD    1 
ATOM   1850 C CE    . LYS D 1 47 ? -39.273 6.433   22.982 1.00 50.66 ? 47  LYS D CE    1 
ATOM   1851 N NZ    . LYS D 1 47 ? -39.501 7.513   23.972 1.00 34.25 ? 47  LYS D NZ    1 
ATOM   1852 N N     . ASN D 1 48 ? -35.878 4.858   25.920 1.00 14.00 ? 48  ASN D N     1 
ATOM   1853 C CA    . ASN D 1 48 ? -36.185 4.445   27.285 1.00 38.54 ? 48  ASN D CA    1 
ATOM   1854 C C     . ASN D 1 48 ? -37.304 5.315   27.848 1.00 51.15 ? 48  ASN D C     1 
ATOM   1855 O O     . ASN D 1 48 ? -38.405 4.823   28.115 1.00 46.37 ? 48  ASN D O     1 
ATOM   1856 C CB    . ASN D 1 48 ? -34.939 4.525   28.164 1.00 41.10 ? 48  ASN D CB    1 
ATOM   1857 C CG    . ASN D 1 48 ? -34.967 3.522   29.304 1.00 39.24 ? 48  ASN D CG    1 
ATOM   1858 O OD1   . ASN D 1 48 ? -34.737 3.874   30.460 1.00 40.64 ? 48  ASN D OD1   1 
ATOM   1859 N ND2   . ASN D 1 48 ? -35.253 2.265   28.982 1.00 48.50 ? 48  ASN D ND2   1 
ATOM   1860 N N     . THR D 1 49 ? -37.031 6.604   28.034 1.00 41.46 ? 49  THR D N     1 
ATOM   1861 C CA    . THR D 1 49 ? -38.060 7.610   28.284 1.00 57.28 ? 49  THR D CA    1 
ATOM   1862 C C     . THR D 1 49 ? -38.257 8.533   27.094 1.00 46.74 ? 49  THR D C     1 
ATOM   1863 O O     . THR D 1 49 ? -39.393 8.884   26.767 1.00 51.37 ? 49  THR D O     1 
ATOM   1864 C CB    . THR D 1 49 ? -37.712 8.446   29.522 1.00 53.52 ? 49  THR D CB    1 
ATOM   1865 O OG1   . THR D 1 49 ? -36.296 8.657   29.584 1.00 59.20 ? 49  THR D OG1   1 
ATOM   1866 C CG2   . THR D 1 49 ? -38.180 7.748   30.791 1.00 50.76 ? 49  THR D CG2   1 
ATOM   1867 N N     . VAL D 1 50 ? -37.165 8.932   26.443 1.00 47.37 ? 50  VAL D N     1 
ATOM   1868 C CA    . VAL D 1 50 ? -37.189 9.597   25.150 1.00 31.72 ? 50  VAL D CA    1 
ATOM   1869 C C     . VAL D 1 50 ? -36.212 8.858   24.243 1.00 31.01 ? 50  VAL D C     1 
ATOM   1870 O O     . VAL D 1 50 ? -35.389 8.064   24.699 1.00 22.64 ? 50  VAL D O     1 
ATOM   1871 C CB    . VAL D 1 50 ? -36.821 11.092  25.245 1.00 43.79 ? 50  VAL D CB    1 
ATOM   1872 C CG1   . VAL D 1 50 ? -37.804 11.826  26.142 1.00 36.23 ? 50  VAL D CG1   1 
ATOM   1873 C CG2   . VAL D 1 50 ? -35.396 11.261  25.754 1.00 21.39 ? 50  VAL D CG2   1 
ATOM   1874 N N     . SER D 1 51 ? -36.311 9.124   22.944 1.00 29.67 ? 51  SER D N     1 
ATOM   1875 C CA    . SER D 1 51 ? -35.378 8.549   21.976 1.00 27.44 ? 51  SER D CA    1 
ATOM   1876 C C     . SER D 1 51 ? -34.134 9.427   21.948 1.00 41.60 ? 51  SER D C     1 
ATOM   1877 O O     . SER D 1 51 ? -34.139 10.511  21.361 1.00 33.57 ? 51  SER D O     1 
ATOM   1878 C CB    . SER D 1 51 ? -36.018 8.447   20.596 1.00 31.98 ? 51  SER D CB    1 
ATOM   1879 O OG    . SER D 1 51 ? -35.060 8.070   19.621 1.00 54.09 ? 51  SER D OG    1 
ATOM   1880 N N     . GLN D 1 52 ? -33.064 8.969   22.588 1.00 32.63 ? 52  GLN D N     1 
ATOM   1881 C CA    . GLN D 1 52 ? -31.842 9.751   22.696 1.00 16.86 ? 52  GLN D CA    1 
ATOM   1882 C C     . GLN D 1 52 ? -30.841 9.345   21.622 1.00 18.93 ? 52  GLN D C     1 
ATOM   1883 O O     . GLN D 1 52 ? -30.869 8.233   21.091 1.00 14.95 ? 52  GLN D O     1 
ATOM   1884 C CB    . GLN D 1 52 ? -31.216 9.601   24.087 1.00 21.89 ? 52  GLN D CB    1 
ATOM   1885 C CG    . GLN D 1 52 ? -30.345 8.374   24.273 1.00 24.34 ? 52  GLN D CG    1 
ATOM   1886 C CD    . GLN D 1 52 ? -29.649 8.362   25.621 1.00 22.03 ? 52  GLN D CD    1 
ATOM   1887 O OE1   . GLN D 1 52 ? -28.634 9.031   25.816 1.00 12.49 ? 52  GLN D OE1   1 
ATOM   1888 N NE2   . GLN D 1 52 ? -30.204 7.611   26.565 1.00 20.55 ? 52  GLN D NE2   1 
ATOM   1889 N N     . MET D 1 53 ? -29.938 10.271  21.325 1.00 21.54 ? 53  MET D N     1 
ATOM   1890 C CA    . MET D 1 53 ? -28.950 10.113  20.268 1.00 16.20 ? 53  MET D CA    1 
ATOM   1891 C C     . MET D 1 53 ? -27.599 9.813   20.903 1.00 24.99 ? 53  MET D C     1 
ATOM   1892 O O     . MET D 1 53 ? -27.054 10.650  21.628 1.00 19.54 ? 53  MET D O     1 
ATOM   1893 C CB    . MET D 1 53 ? -28.882 11.387  19.429 1.00 26.41 ? 53  MET D CB    1 
ATOM   1894 C CG    . MET D 1 53 ? -28.442 11.229  17.988 1.00 10.71 ? 53  MET D CG    1 
ATOM   1895 S SD    . MET D 1 53 ? -28.212 12.881  17.290 1.00 32.42 ? 53  MET D SD    1 
ATOM   1896 C CE    . MET D 1 53 ? -27.784 12.490  15.605 1.00 12.14 ? 53  MET D CE    1 
ATOM   1897 N N     . VAL D 1 54 ? -27.054 8.634   20.610 1.00 21.12 ? 54  VAL D N     1 
ATOM   1898 C CA    . VAL D 1 54 ? -25.766 8.192   21.135 1.00 9.20  ? 54  VAL D CA    1 
ATOM   1899 C C     . VAL D 1 54 ? -24.768 8.144   19.985 1.00 20.84 ? 54  VAL D C     1 
ATOM   1900 O O     . VAL D 1 54 ? -24.969 7.408   19.010 1.00 7.00  ? 54  VAL D O     1 
ATOM   1901 C CB    . VAL D 1 54 ? -25.875 6.821   21.817 1.00 13.35 ? 54  VAL D CB    1 
ATOM   1902 C CG1   . VAL D 1 54 ? -24.517 6.384   22.337 1.00 16.08 ? 54  VAL D CG1   1 
ATOM   1903 C CG2   . VAL D 1 54 ? -26.900 6.865   22.937 1.00 6.62  ? 54  VAL D CG2   1 
ATOM   1904 N N     . TYR D 1 55 ? -23.710 8.942   20.083 1.00 6.73  ? 55  TYR D N     1 
ATOM   1905 C CA    . TYR D 1 55 ? -22.682 8.936   19.051 1.00 12.17 ? 55  TYR D CA    1 
ATOM   1906 C C     . TYR D 1 55 ? -21.846 7.669   19.167 1.00 10.66 ? 55  TYR D C     1 
ATOM   1907 O O     . TYR D 1 55 ? -21.435 7.281   20.264 1.00 2.22  ? 55  TYR D O     1 
ATOM   1908 C CB    . TYR D 1 55 ? -21.802 10.178  19.171 1.00 14.42 ? 55  TYR D CB    1 
ATOM   1909 C CG    . TYR D 1 55 ? -22.355 11.369  18.423 1.00 6.11  ? 55  TYR D CG    1 
ATOM   1910 C CD1   . TYR D 1 55 ? -22.107 11.539  17.068 1.00 5.97  ? 55  TYR D CD1   1 
ATOM   1911 C CD2   . TYR D 1 55 ? -23.135 12.318  19.070 1.00 10.51 ? 55  TYR D CD2   1 
ATOM   1912 C CE1   . TYR D 1 55 ? -22.614 12.623  16.379 1.00 12.72 ? 55  TYR D CE1   1 
ATOM   1913 C CE2   . TYR D 1 55 ? -23.647 13.406  18.389 1.00 6.57  ? 55  TYR D CE2   1 
ATOM   1914 C CZ    . TYR D 1 55 ? -23.382 13.553  17.044 1.00 13.13 ? 55  TYR D CZ    1 
ATOM   1915 O OH    . TYR D 1 55 ? -23.888 14.633  16.360 1.00 6.79  ? 55  TYR D OH    1 
ATOM   1916 N N     . LYS D 1 56 ? -21.601 7.019   18.028 1.00 10.06 ? 56  LYS D N     1 
ATOM   1917 C CA    . LYS D 1 56 ? -20.874 5.755   18.050 1.00 16.00 ? 56  LYS D CA    1 
ATOM   1918 C C     . LYS D 1 56 ? -19.419 5.943   18.459 1.00 12.72 ? 56  LYS D C     1 
ATOM   1919 O O     . LYS D 1 56 ? -18.840 5.049   19.085 1.00 6.75  ? 56  LYS D O     1 
ATOM   1920 C CB    . LYS D 1 56 ? -20.968 5.074   16.684 1.00 12.86 ? 56  LYS D CB    1 
ATOM   1921 C CG    . LYS D 1 56 ? -22.355 4.507   16.390 1.00 12.13 ? 56  LYS D CG    1 
ATOM   1922 C CD    . LYS D 1 56 ? -22.294 3.222   15.573 1.00 34.99 ? 56  LYS D CD    1 
ATOM   1923 C CE    . LYS D 1 56 ? -22.304 3.503   14.076 1.00 34.69 ? 56  LYS D CE    1 
ATOM   1924 N NZ    . LYS D 1 56 ? -23.205 2.565   13.349 1.00 30.54 ? 56  LYS D NZ    1 
ATOM   1925 N N     . HIS D 1 57 ? -18.814 7.091   18.133 1.00 5.84  ? 57  HIS D N     1 
ATOM   1926 C CA    . HIS D 1 57 ? -17.432 7.326   18.538 1.00 9.50  ? 57  HIS D CA    1 
ATOM   1927 C C     . HIS D 1 57 ? -17.281 7.352   20.053 1.00 11.56 ? 57  HIS D C     1 
ATOM   1928 O O     . HIS D 1 57 ? -16.168 7.168   20.558 1.00 4.65  ? 57  HIS D O     1 
ATOM   1929 C CB    . HIS D 1 57 ? -16.905 8.630   17.925 1.00 4.89  ? 57  HIS D CB    1 
ATOM   1930 C CG    . HIS D 1 57 ? -17.654 9.858   18.347 1.00 6.02  ? 57  HIS D CG    1 
ATOM   1931 N ND1   . HIS D 1 57 ? -18.240 10.713  17.440 1.00 1.90  ? 57  HIS D ND1   1 
ATOM   1932 C CD2   . HIS D 1 57 ? -17.877 10.396  19.569 1.00 4.68  ? 57  HIS D CD2   1 
ATOM   1933 C CE1   . HIS D 1 57 ? -18.817 11.710  18.086 1.00 8.08  ? 57  HIS D CE1   1 
ATOM   1934 N NE2   . HIS D 1 57 ? -18.610 11.543  19.380 1.00 3.13  ? 57  HIS D NE2   1 
ATOM   1935 N N     . ALA D 1 58 ? -18.369 7.570   20.786 1.00 3.20  ? 58  ALA D N     1 
ATOM   1936 C CA    . ALA D 1 58 ? -18.352 7.518   22.241 1.00 6.17  ? 58  ALA D CA    1 
ATOM   1937 C C     . ALA D 1 58 ? -18.754 6.155   22.789 1.00 6.37  ? 58  ALA D C     1 
ATOM   1938 O O     . ALA D 1 58 ? -18.794 5.982   24.012 1.00 1.43  ? 58  ALA D O     1 
ATOM   1939 C CB    . ALA D 1 58 ? -19.282 8.588   22.820 1.00 5.10  ? 58  ALA D CB    1 
ATOM   1940 N N     . ILE D 1 59 ? -19.056 5.193   21.922 1.00 2.67  ? 59  ILE D N     1 
ATOM   1941 C CA    . ILE D 1 59 ? -19.477 3.864   22.347 1.00 12.23 ? 59  ILE D CA    1 
ATOM   1942 C C     . ILE D 1 59 ? -18.258 2.955   22.412 1.00 14.91 ? 59  ILE D C     1 
ATOM   1943 O O     . ILE D 1 59 ? -17.423 2.949   21.499 1.00 10.91 ? 59  ILE D O     1 
ATOM   1944 C CB    . ILE D 1 59 ? -20.536 3.290   21.390 1.00 28.56 ? 59  ILE D CB    1 
ATOM   1945 C CG1   . ILE D 1 59 ? -21.784 4.174   21.387 1.00 8.97  ? 59  ILE D CG1   1 
ATOM   1946 C CG2   . ILE D 1 59 ? -20.885 1.873   21.793 1.00 20.27 ? 59  ILE D CG2   1 
ATOM   1947 C CD1   . ILE D 1 59 ? -22.845 3.745   20.396 1.00 5.95  ? 59  ILE D CD1   1 
ATOM   1948 N N     . SER D 1 60 ? -18.153 2.187   23.495 1.00 25.20 ? 60  SER D N     1 
ATOM   1949 C CA    . SER D 1 60 ? -17.140 1.146   23.615 1.00 7.94  ? 60  SER D CA    1 
ATOM   1950 C C     . SER D 1 60 ? -17.715 -0.251  23.433 1.00 19.66 ? 60  SER D C     1 
ATOM   1951 O O     . SER D 1 60 ? -17.083 -1.095  22.790 1.00 12.19 ? 60  SER D O     1 
ATOM   1952 C CB    . SER D 1 60 ? -16.445 1.233   24.978 1.00 17.47 ? 60  SER D CB    1 
ATOM   1953 O OG    . SER D 1 60 ? -17.250 1.913   25.923 1.00 19.48 ? 60  SER D OG    1 
ATOM   1954 N N     . THR D 1 61 ? -18.882 -0.516  24.029 1.00 11.18 ? 61  THR D N     1 
ATOM   1955 C CA    . THR D 1 61 ? -19.524 -1.849  23.973 1.00 15.03 ? 61  THR D CA    1 
ATOM   1956 C C     . THR D 1 61 ? -21.049 -1.796  23.889 1.00 16.79 ? 61  THR D C     1 
ATOM   1957 O O     . THR D 1 61 ? -21.639 -1.017  24.636 1.00 17.66 ? 61  THR D O     1 
ATOM   1958 C CB    . THR D 1 61 ? -19.109 -2.716  25.178 1.00 17.79 ? 61  THR D CB    1 
ATOM   1959 O OG1   . THR D 1 61 ? -17.713 -2.999  25.111 1.00 12.49 ? 61  THR D OG1   1 
ATOM   1960 C CG2   . THR D 1 61 ? -19.877 -4.016  25.251 1.00 27.86 ? 61  THR D CG2   1 
ATOM   1961 N N     . VAL D 1 62 ? -21.645 -2.639  23.037 1.00 28.87 ? 62  VAL D N     1 
ATOM   1962 C CA    . VAL D 1 62 ? -23.115 -2.843  22.904 1.00 11.94 ? 62  VAL D CA    1 
ATOM   1963 C C     . VAL D 1 62 ? -23.396 -4.284  23.352 1.00 28.61 ? 62  VAL D C     1 
ATOM   1964 O O     . VAL D 1 62 ? -23.083 -5.192  22.576 1.00 17.58 ? 62  VAL D O     1 
ATOM   1965 C CB    . VAL D 1 62 ? -23.586 -2.637  21.451 1.00 22.62 ? 62  VAL D CB    1 
ATOM   1966 C CG1   . VAL D 1 62 ? -25.086 -2.842  21.327 1.00 27.63 ? 62  VAL D CG1   1 
ATOM   1967 C CG2   . VAL D 1 62 ? -23.183 -1.279  20.904 1.00 23.17 ? 62  VAL D CG2   1 
ATOM   1968 N N     . VAL D 1 63 ? -23.931 -4.491  24.551 1.00 29.29 ? 63  VAL D N     1 
ATOM   1969 C CA    . VAL D 1 63 ? -24.237 -5.846  25.099 1.00 19.42 ? 63  VAL D CA    1 
ATOM   1970 C C     . VAL D 1 63 ? -25.740 -6.124  25.026 1.00 19.34 ? 63  VAL D C     1 
ATOM   1971 O O     . VAL D 1 63 ? -26.529 -5.283  25.438 1.00 10.83 ? 63  VAL D O     1 
ATOM   1972 C CB    . VAL D 1 63 ? -23.756 -6.042  26.552 1.00 32.36 ? 63  VAL D CB    1 
ATOM   1973 C CG1   . VAL D 1 63 ? -23.550 -7.514  26.863 1.00 30.48 ? 63  VAL D CG1   1 
ATOM   1974 C CG2   . VAL D 1 63 ? -22.491 -5.253  26.859 1.00 35.97 ? 63  VAL D CG2   1 
ATOM   1975 N N     . PRO D 1 64 ? -26.148 -7.294  24.499 1.00 29.92 ? 64  PRO D N     1 
ATOM   1976 C CA    . PRO D 1 64 ? -27.529 -7.694  24.532 1.00 21.46 ? 64  PRO D CA    1 
ATOM   1977 C C     . PRO D 1 64 ? -27.755 -8.198  25.951 1.00 18.83 ? 64  PRO D C     1 
ATOM   1978 O O     . PRO D 1 64 ? -26.846 -8.728  26.520 1.00 27.36 ? 64  PRO D O     1 
ATOM   1979 C CB    . PRO D 1 64 ? -27.663 -8.803  23.494 1.00 16.34 ? 64  PRO D CB    1 
ATOM   1980 C CG    . PRO D 1 64 ? -26.300 -8.889  22.851 1.00 32.66 ? 64  PRO D CG    1 
ATOM   1981 C CD    . PRO D 1 64 ? -25.334 -8.317  23.861 1.00 30.03 ? 64  PRO D CD    1 
ATOM   1982 N N     . SER D 1 65 ? -28.925 -7.967  26.486 1.00 14.58 ? 65  SER D N     1 
ATOM   1983 C CA    . SER D 1 65 ? -29.330 -8.461  27.812 1.00 18.96 ? 65  SER D CA    1 
ATOM   1984 C C     . SER D 1 65 ? -29.424 -9.997  27.793 1.00 27.38 ? 65  SER D C     1 
ATOM   1985 O O     . SER D 1 65 ? -29.409 -10.584 28.863 1.00 46.28 ? 65  SER D O     1 
ATOM   1986 C CB    . SER D 1 65 ? -30.634 -7.833  28.128 1.00 28.42 ? 65  SER D CB    1 
ATOM   1987 O OG    . SER D 1 65 ? -31.595 -8.174  27.143 1.00 31.91 ? 65  SER D OG    1 
ATOM   1988 N N     . ARG D 1 66 ? -29.514 -10.618 26.621 1.00 28.60 ? 66  ARG D N     1 
ATOM   1989 C CA    . ARG D 1 66 ? -29.643 -12.084 26.469 1.00 42.41 ? 66  ARG D CA    1 
ATOM   1990 C C     . ARG D 1 66 ? -29.192 -12.503 25.076 1.00 36.80 ? 66  ARG D C     1 
ATOM   1991 O O     . ARG D 1 66 ? -29.307 -11.688 24.155 1.00 39.36 ? 66  ARG D O     1 
ATOM   1992 C CB    . ARG D 1 66 ? -31.106 -12.512 26.633 1.00 42.69 ? 66  ARG D CB    1 
ATOM   1993 C CG    . ARG D 1 66 ? -32.096 -11.663 25.849 1.00 37.67 ? 66  ARG D CG    1 
ATOM   1994 C CD    . ARG D 1 66 ? -33.518 -12.077 26.173 1.00 56.99 ? 66  ARG D CD    1 
ATOM   1995 N NE    . ARG D 1 66 ? -34.516 -11.168 25.637 1.00 51.11 ? 66  ARG D NE    1 
ATOM   1996 C CZ    . ARG D 1 66 ? -34.758 -10.997 24.347 1.00 47.69 ? 66  ARG D CZ    1 
ATOM   1997 N NH1   . ARG D 1 66 ? -34.113 -11.722 23.452 1.00 49.92 ? 66  ARG D NH1   1 
ATOM   1998 N NH2   . ARG D 1 66 ? -35.625 -10.083 23.956 1.00 35.01 ? 66  ARG D NH2   1 
ATOM   1999 N N     . PRO D 1 67 ? -28.801 -13.773 24.867 1.00 29.90 ? 67  PRO D N     1 
ATOM   2000 C CA    . PRO D 1 67 ? -28.454 -14.223 23.511 1.00 37.73 ? 67  PRO D CA    1 
ATOM   2001 C C     . PRO D 1 67 ? -29.582 -13.920 22.535 1.00 45.62 ? 67  PRO D C     1 
ATOM   2002 O O     . PRO D 1 67 ? -30.760 -14.126 22.834 1.00 70.69 ? 67  PRO D O     1 
ATOM   2003 C CB    . PRO D 1 67 ? -28.228 -15.730 23.681 1.00 41.00 ? 67  PRO D CB    1 
ATOM   2004 C CG    . PRO D 1 67 ? -27.889 -15.899 25.136 1.00 29.94 ? 67  PRO D CG    1 
ATOM   2005 C CD    . PRO D 1 67 ? -28.693 -14.856 25.860 1.00 27.71 ? 67  PRO D CD    1 
ATOM   2006 N N     . VAL D 1 68 ? -29.211 -13.419 21.359 1.00 45.85 ? 68  VAL D N     1 
ATOM   2007 C CA    . VAL D 1 68 ? -30.168 -12.872 20.405 1.00 61.33 ? 68  VAL D CA    1 
ATOM   2008 C C     . VAL D 1 68 ? -30.311 -13.821 19.225 1.00 77.66 ? 68  VAL D C     1 
ATOM   2009 O O     . VAL D 1 68 ? -29.384 -14.565 18.884 1.00 65.93 ? 68  VAL D O     1 
ATOM   2010 C CB    . VAL D 1 68 ? -29.737 -11.470 19.922 1.00 46.65 ? 68  VAL D CB    1 
ATOM   2011 C CG1   . VAL D 1 68 ? -30.812 -10.850 19.036 1.00 47.21 ? 68  VAL D CG1   1 
ATOM   2012 C CG2   . VAL D 1 68 ? -29.419 -10.573 21.109 1.00 38.24 ? 68  VAL D CG2   1 
ATOM   2013 N N     . SER E 1 6  ? -19.663 24.868  6.958  1.00 61.92 ? 6   SER E N     1 
ATOM   2014 C CA    . SER E 1 6  ? -19.362 26.262  7.271  1.00 57.41 ? 6   SER E CA    1 
ATOM   2015 C C     . SER E 1 6  ? -20.188 26.679  8.484  1.00 54.96 ? 6   SER E C     1 
ATOM   2016 O O     . SER E 1 6  ? -21.237 27.308  8.372  1.00 64.23 ? 6   SER E O     1 
ATOM   2017 C CB    . SER E 1 6  ? -19.624 27.148  6.062  1.00 74.67 ? 6   SER E CB    1 
ATOM   2018 O OG    . SER E 1 6  ? -19.051 28.413  6.283  1.00 77.90 ? 6   SER E OG    1 
ATOM   2019 N N     . LEU E 1 7  ? -19.704 26.308  9.653  1.00 43.03 ? 7   LEU E N     1 
ATOM   2020 C CA    . LEU E 1 7  ? -20.214 26.816  10.919 1.00 32.13 ? 7   LEU E CA    1 
ATOM   2021 C C     . LEU E 1 7  ? -19.081 27.140  11.877 1.00 36.37 ? 7   LEU E C     1 
ATOM   2022 O O     . LEU E 1 7  ? -19.173 28.123  12.609 1.00 47.06 ? 7   LEU E O     1 
ATOM   2023 C CB    . LEU E 1 7  ? -21.182 25.826  11.592 1.00 49.43 ? 7   LEU E CB    1 
ATOM   2024 C CG    . LEU E 1 7  ? -22.428 26.441  12.242 1.00 48.93 ? 7   LEU E CG    1 
ATOM   2025 C CD1   . LEU E 1 7  ? -23.424 26.914  11.195 1.00 44.02 ? 7   LEU E CD1   1 
ATOM   2026 C CD2   . LEU E 1 7  ? -23.053 25.408  13.164 1.00 23.49 ? 7   LEU E CD2   1 
ATOM   2027 N N     . GLN E 1 8  ? -18.005 26.347  11.875 1.00 44.95 ? 8   GLN E N     1 
ATOM   2028 C CA    . GLN E 1 8  ? -16.862 26.635  12.737 1.00 23.09 ? 8   GLN E CA    1 
ATOM   2029 C C     . GLN E 1 8  ? -16.227 27.972  12.373 1.00 31.97 ? 8   GLN E C     1 
ATOM   2030 O O     . GLN E 1 8  ? -16.096 28.869  13.215 1.00 22.67 ? 8   GLN E O     1 
ATOM   2031 C CB    . GLN E 1 8  ? -15.817 25.524  12.618 1.00 33.15 ? 8   GLN E CB    1 
ATOM   2032 C CG    . GLN E 1 8  ? -16.096 24.273  13.409 1.00 35.52 ? 8   GLN E CG    1 
ATOM   2033 C CD    . GLN E 1 8  ? -14.950 23.288  13.316 1.00 34.63 ? 8   GLN E CD    1 
ATOM   2034 O OE1   . GLN E 1 8  ? -13.838 23.570  13.763 1.00 19.92 ? 8   GLN E OE1   1 
ATOM   2035 N NE2   . GLN E 1 8  ? -15.207 22.135  12.710 1.00 37.76 ? 8   GLN E NE2   1 
ATOM   2036 N N     . ASP E 1 9  ? -15.808 28.109  11.116 1.00 21.86 ? 9   ASP E N     1 
ATOM   2037 C CA    . ASP E 1 9  ? -15.073 29.293  10.675 1.00 35.00 ? 9   ASP E CA    1 
ATOM   2038 C C     . ASP E 1 9  ? -15.772 30.594  11.035 1.00 42.47 ? 9   ASP E C     1 
ATOM   2039 O O     . ASP E 1 9  ? -15.128 31.465  11.645 1.00 26.77 ? 9   ASP E O     1 
ATOM   2040 C CB    . ASP E 1 9  ? -14.846 29.196  9.160  1.00 34.96 ? 9   ASP E CB    1 
ATOM   2041 C CG    . ASP E 1 9  ? -13.677 28.297  8.803  1.00 48.50 ? 9   ASP E CG    1 
ATOM   2042 O OD1   . ASP E 1 9  ? -13.369 27.377  9.591  1.00 36.09 ? 9   ASP E OD1   1 
ATOM   2043 O OD2   . ASP E 1 9  ? -13.070 28.506  7.731  1.00 40.44 ? 9   ASP E OD2   1 
ATOM   2044 N N     . PRO E 1 10 ? -17.046 30.803  10.698 1.00 31.53 ? 10  PRO E N     1 
ATOM   2045 C CA    . PRO E 1 10 ? -17.721 32.034  11.140 1.00 25.70 ? 10  PRO E CA    1 
ATOM   2046 C C     . PRO E 1 10 ? -17.666 32.233  12.644 1.00 29.10 ? 10  PRO E C     1 
ATOM   2047 O O     . PRO E 1 10 ? -17.490 33.365  13.111 1.00 25.02 ? 10  PRO E O     1 
ATOM   2048 C CB    . PRO E 1 10 ? -19.166 31.845  10.650 1.00 36.89 ? 10  PRO E CB    1 
ATOM   2049 C CG    . PRO E 1 10 ? -19.277 30.412  10.248 1.00 38.60 ? 10  PRO E CG    1 
ATOM   2050 C CD    . PRO E 1 10 ? -17.912 29.978  9.842  1.00 39.79 ? 10  PRO E CD    1 
ATOM   2051 N N     . PHE E 1 11 ? -17.805 31.155  13.418 1.00 25.08 ? 11  PHE E N     1 
ATOM   2052 C CA    . PHE E 1 11 ? -17.836 31.276  14.872 1.00 23.43 ? 11  PHE E CA    1 
ATOM   2053 C C     . PHE E 1 11 ? -16.502 31.783  15.407 1.00 25.29 ? 11  PHE E C     1 
ATOM   2054 O O     . PHE E 1 11 ? -16.434 32.847  16.033 1.00 16.19 ? 11  PHE E O     1 
ATOM   2055 C CB    . PHE E 1 11 ? -18.193 29.927  15.503 1.00 32.90 ? 11  PHE E CB    1 
ATOM   2056 C CG    . PHE E 1 11 ? -18.306 29.968  17.004 1.00 24.56 ? 11  PHE E CG    1 
ATOM   2057 C CD1   . PHE E 1 11 ? -19.492 30.342  17.613 1.00 29.28 ? 11  PHE E CD1   1 
ATOM   2058 C CD2   . PHE E 1 11 ? -17.226 29.631  17.805 1.00 19.42 ? 11  PHE E CD2   1 
ATOM   2059 C CE1   . PHE E 1 11 ? -19.599 30.382  18.992 1.00 24.18 ? 11  PHE E CE1   1 
ATOM   2060 C CE2   . PHE E 1 11 ? -17.328 29.670  19.184 1.00 11.89 ? 11  PHE E CE2   1 
ATOM   2061 C CZ    . PHE E 1 11 ? -18.516 30.045  19.777 1.00 25.70 ? 11  PHE E CZ    1 
ATOM   2062 N N     . LEU E 1 12 ? -15.425 31.031  15.167 1.00 27.90 ? 12  LEU E N     1 
ATOM   2063 C CA    . LEU E 1 12 ? -14.127 31.397  15.725 1.00 27.02 ? 12  LEU E CA    1 
ATOM   2064 C C     . LEU E 1 12 ? -13.672 32.763  15.227 1.00 22.27 ? 12  LEU E C     1 
ATOM   2065 O O     . LEU E 1 12 ? -13.151 33.572  16.004 1.00 22.75 ? 12  LEU E O     1 
ATOM   2066 C CB    . LEU E 1 12 ? -13.090 30.330  15.376 1.00 21.62 ? 12  LEU E CB    1 
ATOM   2067 C CG    . LEU E 1 12 ? -13.299 28.941  15.982 1.00 27.78 ? 12  LEU E CG    1 
ATOM   2068 C CD1   . LEU E 1 12 ? -12.383 27.929  15.312 1.00 21.09 ? 12  LEU E CD1   1 
ATOM   2069 C CD2   . LEU E 1 12 ? -13.062 28.963  17.483 1.00 13.20 ? 12  LEU E CD2   1 
ATOM   2070 N N     . ASN E 1 13 ? -13.859 33.040  13.933 1.00 15.42 ? 13  ASN E N     1 
ATOM   2071 C CA    . ASN E 1 13 ? -13.433 34.324  13.385 1.00 34.68 ? 13  ASN E CA    1 
ATOM   2072 C C     . ASN E 1 13 ? -14.127 35.487  14.082 1.00 32.31 ? 13  ASN E C     1 
ATOM   2073 O O     . ASN E 1 13 ? -13.524 36.551  14.263 1.00 32.53 ? 13  ASN E O     1 
ATOM   2074 C CB    . ASN E 1 13 ? -13.706 34.374  11.881 1.00 36.73 ? 13  ASN E CB    1 
ATOM   2075 C CG    . ASN E 1 13 ? -12.490 34.002  11.050 1.00 45.11 ? 13  ASN E CG    1 
ATOM   2076 O OD1   . ASN E 1 13 ? -11.353 34.085  11.515 1.00 44.33 ? 13  ASN E OD1   1 
ATOM   2077 N ND2   . ASN E 1 13 ? -12.726 33.592  9.810  1.00 46.30 ? 13  ASN E ND2   1 
ATOM   2078 N N     . ALA E 1 14 ? -15.367 35.309  14.534 1.00 27.15 ? 14  ALA E N     1 
ATOM   2079 C CA    . ALA E 1 14 ? -16.172 36.357  15.193 1.00 27.01 ? 14  ALA E CA    1 
ATOM   2080 C C     . ALA E 1 14 ? -15.507 36.731  16.513 1.00 29.00 ? 14  ALA E C     1 
ATOM   2081 O O     . ALA E 1 14 ? -15.387 37.910  16.802 1.00 30.13 ? 14  ALA E O     1 
ATOM   2082 C CB    . ALA E 1 14 ? -17.575 35.864  15.386 1.00 27.97 ? 14  ALA E CB    1 
ATOM   2083 N N     . LEU E 1 15 ? -15.044 35.746  17.264 1.00 31.56 ? 15  LEU E N     1 
ATOM   2084 C CA    . LEU E 1 15 ? -14.289 35.999  18.520 1.00 31.45 ? 15  LEU E CA    1 
ATOM   2085 C C     . LEU E 1 15 ? -12.910 36.583  18.179 1.00 27.64 ? 15  LEU E C     1 
ATOM   2086 O O     . LEU E 1 15 ? -12.439 37.423  18.944 1.00 24.02 ? 15  LEU E O     1 
ATOM   2087 C CB    . LEU E 1 15 ? -14.159 34.675  19.278 1.00 31.31 ? 15  LEU E CB    1 
ATOM   2088 C CG    . LEU E 1 15 ? -15.471 34.051  19.733 1.00 26.71 ? 15  LEU E CG    1 
ATOM   2089 C CD1   . LEU E 1 15 ? -15.680 32.694  19.084 1.00 31.84 ? 15  LEU E CD1   1 
ATOM   2090 C CD2   . LEU E 1 15 ? -15.503 33.941  21.245 1.00 36.87 ? 15  LEU E CD2   1 
ATOM   2091 N N     . ARG E 1 16 ? -12.304 36.164  17.062 1.00 25.23 ? 16  ARG E N     1 
ATOM   2092 C CA    . ARG E 1 16 ? -10.946 36.609  16.640 1.00 30.63 ? 16  ARG E CA    1 
ATOM   2093 C C     . ARG E 1 16 ? -11.035 38.052  16.151 1.00 33.13 ? 16  ARG E C     1 
ATOM   2094 O O     . ARG E 1 16 ? -10.057 38.768  16.296 1.00 40.57 ? 16  ARG E O     1 
ATOM   2095 C CB    . ARG E 1 16 ? -10.376 35.723  15.532 1.00 31.64 ? 16  ARG E CB    1 
ATOM   2096 C CG    . ARG E 1 16 ? -8.881  35.857  15.296 1.00 24.93 ? 16  ARG E CG    1 
ATOM   2097 C CD    . ARG E 1 16 ? -8.563  35.815  13.821 1.00 40.07 ? 16  ARG E CD    1 
ATOM   2098 N NE    . ARG E 1 16 ? -9.244  36.877  13.101 1.00 57.41 ? 16  ARG E NE    1 
ATOM   2099 C CZ    . ARG E 1 16 ? -10.037 36.687  12.058 1.00 51.21 ? 16  ARG E CZ    1 
ATOM   2100 N NH1   . ARG E 1 16 ? -9.615  35.968  11.036 1.00 42.66 ? 16  ARG E NH1   1 
ATOM   2101 N NH2   . ARG E 1 16 ? -11.253 37.204  12.051 1.00 40.24 ? 16  ARG E NH2   1 
ATOM   2102 N N     . ARG E 1 17 ? -12.174 38.455  15.599 1.00 40.78 ? 17  ARG E N     1 
ATOM   2103 C CA    . ARG E 1 17 ? -12.306 39.804  15.061 1.00 35.08 ? 17  ARG E CA    1 
ATOM   2104 C C     . ARG E 1 17 ? -12.676 40.814  16.140 1.00 25.73 ? 17  ARG E C     1 
ATOM   2105 O O     . ARG E 1 17 ? -12.141 41.927  16.152 1.00 34.40 ? 17  ARG E O     1 
ATOM   2106 C CB    . ARG E 1 17 ? -13.353 39.814  13.942 1.00 29.21 ? 17  ARG E CB    1 
ATOM   2107 C CG    . ARG E 1 17 ? -13.884 41.190  13.566 1.00 41.17 ? 17  ARG E CG    1 
ATOM   2108 C CD    . ARG E 1 17 ? -15.066 41.073  12.608 1.00 38.62 ? 17  ARG E CD    1 
ATOM   2109 N NE    . ARG E 1 17 ? -16.292 40.726  13.318 1.00 38.90 ? 17  ARG E NE    1 
ATOM   2110 C CZ    . ARG E 1 17 ? -16.925 39.563  13.221 1.00 34.26 ? 17  ARG E CZ    1 
ATOM   2111 N NH1   . ARG E 1 17 ? -16.487 38.595  12.431 1.00 35.87 ? 17  ARG E NH1   1 
ATOM   2112 N NH2   . ARG E 1 17 ? -18.032 39.370  13.932 1.00 24.42 ? 17  ARG E NH2   1 
ATOM   2113 N N     . GLU E 1 18 ? -13.583 40.452  17.042 1.00 25.87 ? 18  GLU E N     1 
ATOM   2114 C CA    . GLU E 1 18 ? -14.018 41.345  18.107 1.00 21.86 ? 18  GLU E CA    1 
ATOM   2115 C C     . GLU E 1 18 ? -13.128 41.270  19.340 1.00 35.08 ? 18  GLU E C     1 
ATOM   2116 O O     . GLU E 1 18 ? -13.356 42.017  20.297 1.00 35.32 ? 18  GLU E O     1 
ATOM   2117 C CB    . GLU E 1 18 ? -15.466 41.032  18.502 1.00 38.34 ? 18  GLU E CB    1 
ATOM   2118 C CG    . GLU E 1 18 ? -16.436 40.959  17.334 1.00 47.50 ? 18  GLU E CG    1 
ATOM   2119 C CD    . GLU E 1 18 ? -16.740 42.319  16.740 1.00 54.56 ? 18  GLU E CD    1 
ATOM   2120 O OE1   . GLU E 1 18 ? -16.779 42.429  15.497 1.00 44.95 ? 18  GLU E OE1   1 
ATOM   2121 O OE2   . GLU E 1 18 ? -16.940 43.277  17.515 1.00 47.71 ? 18  GLU E OE2   1 
ATOM   2122 N N     . ARG E 1 19 ? -12.138 40.369  19.318 1.00 27.39 ? 19  ARG E N     1 
ATOM   2123 C CA    . ARG E 1 19 ? -11.143 40.267  20.411 1.00 17.37 ? 19  ARG E CA    1 
ATOM   2124 C C     . ARG E 1 19 ? -11.874 39.959  21.710 1.00 22.21 ? 19  ARG E C     1 
ATOM   2125 O O     . ARG E 1 19 ? -11.612 40.634  22.705 1.00 31.18 ? 19  ARG E O     1 
ATOM   2126 C CB    . ARG E 1 19 ? -10.322 41.557  20.473 1.00 36.25 ? 19  ARG E CB    1 
ATOM   2127 C CG    . ARG E 1 19 ? -9.654  41.937  19.165 1.00 28.62 ? 19  ARG E CG    1 
ATOM   2128 C CD    . ARG E 1 19 ? -8.634  40.890  18.784 1.00 36.01 ? 19  ARG E CD    1 
ATOM   2129 N NE    . ARG E 1 19 ? -7.599  41.450  17.936 1.00 28.46 ? 19  ARG E NE    1 
ATOM   2130 C CZ    . ARG E 1 19 ? -7.668  41.547  16.614 1.00 39.89 ? 19  ARG E CZ    1 
ATOM   2131 N NH1   . ARG E 1 19 ? -8.798  41.298  15.979 1.00 37.21 ? 19  ARG E NH1   1 
ATOM   2132 N NH2   . ARG E 1 19 ? -6.594  41.895  15.929 1.00 36.42 ? 19  ARG E NH2   1 
ATOM   2133 N N     . VAL E 1 20 ? -12.742 38.952  21.693 1.00 35.21 ? 20  VAL E N     1 
ATOM   2134 C CA    . VAL E 1 20 ? -13.548 38.561  22.880 1.00 31.08 ? 20  VAL E CA    1 
ATOM   2135 C C     . VAL E 1 20 ? -12.811 37.499  23.684 1.00 17.17 ? 20  VAL E C     1 
ATOM   2136 O O     . VAL E 1 20 ? -12.473 36.481  23.121 1.00 13.01 ? 20  VAL E O     1 
ATOM   2137 C CB    . VAL E 1 20 ? -14.947 38.045  22.504 1.00 31.82 ? 20  VAL E CB    1 
ATOM   2138 C CG1   . VAL E 1 20 ? -15.793 37.790  23.739 1.00 33.55 ? 20  VAL E CG1   1 
ATOM   2139 C CG2   . VAL E 1 20 ? -15.645 38.992  21.547 1.00 31.69 ? 20  VAL E CG2   1 
ATOM   2140 N N     . PRO E 1 21 ? -12.670 37.693  25.011 1.00 21.07 ? 21  PRO E N     1 
ATOM   2141 C CA    . PRO E 1 21 ? -12.089 36.679  25.876 1.00 12.71 ? 21  PRO E CA    1 
ATOM   2142 C C     . PRO E 1 21 ? -12.898 35.386  25.747 1.00 22.71 ? 21  PRO E C     1 
ATOM   2143 O O     . PRO E 1 21 ? -14.101 35.463  25.740 1.00 21.97 ? 21  PRO E O     1 
ATOM   2144 C CB    . PRO E 1 21 ? -12.225 37.187  27.312 1.00 24.19 ? 21  PRO E CB    1 
ATOM   2145 C CG    . PRO E 1 21 ? -12.812 38.584  27.210 1.00 28.03 ? 21  PRO E CG    1 
ATOM   2146 C CD    . PRO E 1 21 ? -13.123 38.859  25.753 1.00 25.12 ? 21  PRO E CD    1 
ATOM   2147 N N     . ALA E 1 22 ? -12.224 34.246  25.637 1.00 26.71 ? 22  ALA E N     1 
ATOM   2148 C CA    . ALA E 1 22 ? -12.902 32.958  25.402 1.00 24.69 ? 22  ALA E CA    1 
ATOM   2149 C C     . ALA E 1 22 ? -12.401 31.857  26.328 1.00 15.54 ? 22  ALA E C     1 
ATOM   2150 O O     . ALA E 1 22 ? -11.249 31.905  26.751 1.00 12.58 ? 22  ALA E O     1 
ATOM   2151 C CB    . ALA E 1 22 ? -12.747 32.547  23.955 1.00 30.00 ? 22  ALA E CB    1 
ATOM   2152 N N     . SER E 1 23 ? -13.272 30.895  26.590 1.00 26.70 ? 23  SER E N     1 
ATOM   2153 C CA    . SER E 1 23 ? -12.948 29.705  27.392 1.00 21.69 ? 23  SER E CA    1 
ATOM   2154 C C     . SER E 1 23 ? -12.971 28.483  26.466 1.00 29.99 ? 23  SER E C     1 
ATOM   2155 O O     . SER E 1 23 ? -13.983 28.296  25.782 1.00 26.08 ? 23  SER E O     1 
ATOM   2156 C CB    . SER E 1 23 ? -13.896 29.590  28.545 1.00 24.04 ? 23  SER E CB    1 
ATOM   2157 O OG    . SER E 1 23 ? -13.277 29.980  29.748 1.00 26.43 ? 23  SER E OG    1 
ATOM   2158 N N     . ILE E 1 24 ? -11.862 27.739  26.372 1.00 31.09 ? 24  ILE E N     1 
ATOM   2159 C CA    . ILE E 1 24 ? -11.787 26.484  25.576 1.00 27.45 ? 24  ILE E CA    1 
ATOM   2160 C C     . ILE E 1 24 ? -11.771 25.316  26.570 1.00 10.89 ? 24  ILE E C     1 
ATOM   2161 O O     . ILE E 1 24 ? -10.784 25.171  27.277 1.00 11.17 ? 24  ILE E O     1 
ATOM   2162 C CB    . ILE E 1 24 ? -10.589 26.471  24.617 1.00 24.50 ? 24  ILE E CB    1 
ATOM   2163 C CG1   . ILE E 1 24 ? -10.764 27.477  23.482 1.00 11.88 ? 24  ILE E CG1   1 
ATOM   2164 C CG2   . ILE E 1 24 ? -10.351 25.061  24.104 1.00 14.46 ? 24  ILE E CG2   1 
ATOM   2165 C CD1   . ILE E 1 24 ? -9.586  27.541  22.550 1.00 19.32 ? 24  ILE E CD1   1 
ATOM   2166 N N     . TYR E 1 25 ? -12.874 24.598  26.659 1.00 8.69  ? 25  TYR E N     1 
ATOM   2167 C CA    . TYR E 1 25 ? -13.010 23.420  27.540 1.00 17.42 ? 25  TYR E CA    1 
ATOM   2168 C C     . TYR E 1 25 ? -12.450 22.221  26.776 1.00 13.55 ? 25  TYR E C     1 
ATOM   2169 O O     . TYR E 1 25 ? -12.909 22.029  25.693 1.00 15.04 ? 25  TYR E O     1 
ATOM   2170 C CB    . TYR E 1 25 ? -14.466 23.226  27.947 1.00 11.80 ? 25  TYR E CB    1 
ATOM   2171 C CG    . TYR E 1 25 ? -14.963 24.206  28.972 1.00 23.32 ? 25  TYR E CG    1 
ATOM   2172 C CD1   . TYR E 1 25 ? -14.805 23.953  30.323 1.00 19.45 ? 25  TYR E CD1   1 
ATOM   2173 C CD2   . TYR E 1 25 ? -15.573 25.387  28.593 1.00 13.89 ? 25  TYR E CD2   1 
ATOM   2174 C CE1   . TYR E 1 25 ? -15.255 24.844  31.277 1.00 9.33  ? 25  TYR E CE1   1 
ATOM   2175 C CE2   . TYR E 1 25 ? -16.023 26.292  29.538 1.00 21.67 ? 25  TYR E CE2   1 
ATOM   2176 C CZ    . TYR E 1 25 ? -15.869 26.015  30.883 1.00 11.32 ? 25  TYR E CZ    1 
ATOM   2177 O OH    . TYR E 1 25 ? -16.316 26.899  31.817 1.00 10.35 ? 25  TYR E OH    1 
ATOM   2178 N N     . LEU E 1 26 ? -11.412 21.576  27.261 1.00 13.90 ? 26  LEU E N     1 
ATOM   2179 C CA    . LEU E 1 26 ? -10.857 20.382  26.646 1.00 29.89 ? 26  LEU E CA    1 
ATOM   2180 C C     . LEU E 1 26 ? -11.705 19.154  26.985 1.00 13.43 ? 26  LEU E C     1 
ATOM   2181 O O     . LEU E 1 26 ? -12.600 19.192  27.832 1.00 13.43 ? 26  LEU E O     1 
ATOM   2182 C CB    . LEU E 1 26 ? -9.414  20.173  27.098 1.00 16.58 ? 26  LEU E CB    1 
ATOM   2183 C CG    . LEU E 1 26 ? -8.416  21.282  26.759 1.00 7.71  ? 26  LEU E CG    1 
ATOM   2184 C CD1   . LEU E 1 26 ? -7.029  20.931  27.267 1.00 15.79 ? 26  LEU E CD1   1 
ATOM   2185 C CD2   . LEU E 1 26 ? -8.402  21.536  25.271 1.00 22.61 ? 26  LEU E CD2   1 
ATOM   2186 N N     . VAL E 1 27 ? -11.407 18.040  26.309 1.00 17.32 ? 27  VAL E N     1 
ATOM   2187 C CA    . VAL E 1 27 ? -12.193 16.825  26.494 1.00 12.90 ? 27  VAL E CA    1 
ATOM   2188 C C     . VAL E 1 27 ? -12.037 16.225  27.882 1.00 8.11  ? 27  VAL E C     1 
ATOM   2189 O O     . VAL E 1 27 ? -12.837 15.364  28.266 1.00 11.55 ? 27  VAL E O     1 
ATOM   2190 C CB    . VAL E 1 27 ? -11.821 15.764  25.438 1.00 9.34  ? 27  VAL E CB    1 
ATOM   2191 C CG1   . VAL E 1 27 ? -12.277 16.213  24.061 1.00 12.40 ? 27  VAL E CG1   1 
ATOM   2192 C CG2   . VAL E 1 27 ? -10.324 15.496  25.453 1.00 31.49 ? 27  VAL E CG2   1 
ATOM   2193 N N     . ASN E 1 28 ? -11.033 16.654  28.644 1.00 13.67 ? 28  ASN E N     1 
ATOM   2194 C CA    . ASN E 1 28 ? -10.810 16.156  29.994 1.00 7.28  ? 28  ASN E CA    1 
ATOM   2195 C C     . ASN E 1 28 ? -11.252 17.148  31.063 1.00 7.58  ? 28  ASN E C     1 
ATOM   2196 O O     . ASN E 1 28 ? -10.898 16.981  32.235 1.00 21.06 ? 28  ASN E O     1 
ATOM   2197 C CB    . ASN E 1 28 ? -9.333  15.801  30.187 1.00 19.76 ? 28  ASN E CB    1 
ATOM   2198 C CG    . ASN E 1 28 ? -8.431  17.019  30.181 1.00 29.02 ? 28  ASN E CG    1 
ATOM   2199 O OD1   . ASN E 1 28 ? -8.755  18.049  29.589 1.00 14.60 ? 28  ASN E OD1   1 
ATOM   2200 N ND2   . ASN E 1 28 ? -7.283  16.904  30.839 1.00 28.46 ? 28  ASN E ND2   1 
ATOM   2201 N N     . GLY E 1 29 ? -12.015 18.174  30.686 1.00 18.10 ? 29  GLY E N     1 
ATOM   2202 C CA    . GLY E 1 29 ? -12.556 19.123  31.632 1.00 12.13 ? 29  GLY E CA    1 
ATOM   2203 C C     . GLY E 1 29 ? -11.719 20.361  31.858 1.00 26.91 ? 29  GLY E C     1 
ATOM   2204 O O     . GLY E 1 29 ? -12.222 21.330  32.443 1.00 9.84  ? 29  GLY E O     1 
ATOM   2205 N N     . ILE E 1 30 ? -10.460 20.362  31.417 1.00 21.37 ? 30  ILE E N     1 
ATOM   2206 C CA    . ILE E 1 30 ? -9.598  21.518  31.617 1.00 21.29 ? 30  ILE E CA    1 
ATOM   2207 C C     . ILE E 1 30 ? -10.179 22.713  30.876 1.00 8.65  ? 30  ILE E C     1 
ATOM   2208 O O     . ILE E 1 30 ? -10.592 22.606  29.714 1.00 16.48 ? 30  ILE E O     1 
ATOM   2209 C CB    . ILE E 1 30 ? -8.169  21.204  31.145 1.00 22.62 ? 30  ILE E CB    1 
ATOM   2210 C CG1   . ILE E 1 30 ? -7.420  20.310  32.150 1.00 19.81 ? 30  ILE E CG1   1 
ATOM   2211 C CG2   . ILE E 1 30 ? -7.404  22.503  30.875 1.00 22.15 ? 30  ILE E CG2   1 
ATOM   2212 C CD1   . ILE E 1 30 ? -8.226  19.834  33.355 1.00 25.09 ? 30  ILE E CD1   1 
ATOM   2213 N N     . LYS E 1 31 ? -10.241 23.844  31.565 1.00 6.54  ? 31  LYS E N     1 
ATOM   2214 C CA    . LYS E 1 31 ? -10.739 25.106  30.968 1.00 15.68 ? 31  LYS E CA    1 
ATOM   2215 C C     . LYS E 1 31 ? -9.575  26.054  30.686 1.00 15.96 ? 31  LYS E C     1 
ATOM   2216 O O     . LYS E 1 31 ? -8.931  26.518  31.626 1.00 13.26 ? 31  LYS E O     1 
ATOM   2217 C CB    . LYS E 1 31 ? -11.778 25.803  31.841 1.00 17.82 ? 31  LYS E CB    1 
ATOM   2218 C CG    . LYS E 1 31 ? -12.305 27.143  31.346 1.00 18.43 ? 31  LYS E CG    1 
ATOM   2219 C CD    . LYS E 1 31 ? -12.532 28.114  32.487 1.00 16.39 ? 31  LYS E CD    1 
ATOM   2220 C CE    . LYS E 1 31 ? -13.755 28.986  32.316 1.00 22.83 ? 31  LYS E CE    1 
ATOM   2221 N NZ    . LYS E 1 31 ? -14.567 29.059  33.551 1.00 30.93 ? 31  LYS E NZ    1 
ATOM   2222 N N     . LEU E 1 32 ? -9.308  26.266  29.418 1.00 11.13 ? 32  LEU E N     1 
ATOM   2223 C CA    . LEU E 1 32 ? -8.335  27.276  28.987 1.00 15.31 ? 32  LEU E CA    1 
ATOM   2224 C C     . LEU E 1 32 ? -9.082  28.604  28.867 1.00 15.66 ? 32  LEU E C     1 
ATOM   2225 O O     . LEU E 1 32 ? -10.197 28.578  28.399 1.00 8.30  ? 32  LEU E O     1 
ATOM   2226 C CB    . LEU E 1 32 ? -7.754  26.895  27.626 1.00 15.82 ? 32  LEU E CB    1 
ATOM   2227 C CG    . LEU E 1 32 ? -7.026  25.552  27.557 1.00 32.39 ? 32  LEU E CG    1 
ATOM   2228 C CD1   . LEU E 1 32 ? -6.218  25.429  26.276 1.00 11.94 ? 32  LEU E CD1   1 
ATOM   2229 C CD2   . LEU E 1 32 ? -6.135  25.354  28.765 1.00 12.96 ? 32  LEU E CD2   1 
ATOM   2230 N N     . GLN E 1 33 ? -8.454  29.700  29.280 1.00 19.69 ? 33  GLN E N     1 
ATOM   2231 C CA    . GLN E 1 33 ? -9.007  31.069  29.128 1.00 27.23 ? 33  GLN E CA    1 
ATOM   2232 C C     . GLN E 1 33 ? -7.953  31.914  28.425 1.00 28.64 ? 33  GLN E C     1 
ATOM   2233 O O     . GLN E 1 33 ? -6.845  31.981  28.927 1.00 21.30 ? 33  GLN E O     1 
ATOM   2234 C CB    . GLN E 1 33 ? -9.371  31.698  30.469 1.00 21.90 ? 33  GLN E CB    1 
ATOM   2235 C CG    . GLN E 1 33 ? -10.587 31.082  31.128 1.00 23.99 ? 33  GLN E CG    1 
ATOM   2236 C CD    . GLN E 1 33 ? -10.544 31.335  32.610 1.00 16.26 ? 33  GLN E CD    1 
ATOM   2237 O OE1   . GLN E 1 33 ? -11.110 32.300  33.114 1.00 42.10 ? 33  GLN E OE1   1 
ATOM   2238 N NE2   . GLN E 1 33 ? -9.842  30.471  33.319 1.00 39.49 ? 33  GLN E NE2   1 
ATOM   2239 N N     . GLY E 1 34 ? -8.299  32.515  27.299 1.00 26.57 ? 34  GLY E N     1 
ATOM   2240 C CA    . GLY E 1 34 ? -7.391  33.420  26.582 1.00 24.75 ? 34  GLY E CA    1 
ATOM   2241 C C     . GLY E 1 34 ? -8.117  34.105  25.454 1.00 18.94 ? 34  GLY E C     1 
ATOM   2242 O O     . GLY E 1 34 ? -9.288  34.442  25.654 1.00 28.07 ? 34  GLY E O     1 
ATOM   2243 N N     . GLN E 1 35 ? -7.482  34.224  24.301 1.00 12.73 ? 35  GLN E N     1 
ATOM   2244 C CA    . GLN E 1 35 ? -8.078  34.902  23.131 1.00 24.60 ? 35  GLN E CA    1 
ATOM   2245 C C     . GLN E 1 35 ? -7.755  34.147  21.849 1.00 16.07 ? 35  GLN E C     1 
ATOM   2246 O O     . GLN E 1 35 ? -6.619  33.697  21.706 1.00 13.49 ? 35  GLN E O     1 
ATOM   2247 C CB    . GLN E 1 35 ? -7.572  36.340  22.971 1.00 30.59 ? 35  GLN E CB    1 
ATOM   2248 C CG    . GLN E 1 35 ? -8.117  37.304  24.006 1.00 35.66 ? 35  GLN E CG    1 
ATOM   2249 C CD    . GLN E 1 35 ? -8.712  38.529  23.360 1.00 41.08 ? 35  GLN E CD    1 
ATOM   2250 O OE1   . GLN E 1 35 ? -9.916  38.751  23.414 1.00 28.71 ? 35  GLN E OE1   1 
ATOM   2251 N NE2   . GLN E 1 35 ? -7.866  39.333  22.738 1.00 40.55 ? 35  GLN E NE2   1 
ATOM   2252 N N     . ILE E 1 36 ? -8.736  34.037  20.970 1.00 22.46 ? 36  ILE E N     1 
ATOM   2253 C CA    . ILE E 1 36 ? -8.578  33.343  19.658 1.00 16.78 ? 36  ILE E CA    1 
ATOM   2254 C C     . ILE E 1 36 ? -7.771  34.238  18.725 1.00 16.40 ? 36  ILE E C     1 
ATOM   2255 O O     . ILE E 1 36 ? -8.365  35.147  18.150 1.00 13.63 ? 36  ILE E O     1 
ATOM   2256 C CB    . ILE E 1 36 ? -9.942  32.981  19.040 1.00 14.21 ? 36  ILE E CB    1 
ATOM   2257 C CG1   . ILE E 1 36 ? -10.772 32.077  19.955 1.00 25.63 ? 36  ILE E CG1   1 
ATOM   2258 C CG2   . ILE E 1 36 ? -9.755  32.364  17.665 1.00 23.00 ? 36  ILE E CG2   1 
ATOM   2259 C CD1   . ILE E 1 36 ? -10.385 30.621  19.891 1.00 14.78 ? 36  ILE E CD1   1 
ATOM   2260 N N     . GLU E 1 37 ? -6.480  33.958  18.580 1.00 16.85 ? 37  GLU E N     1 
ATOM   2261 C CA    . GLU E 1 37 ? -5.591  34.713  17.668 1.00 12.77 ? 37  GLU E CA    1 
ATOM   2262 C C     . GLU E 1 37 ? -5.707  34.185  16.237 1.00 18.61 ? 37  GLU E C     1 
ATOM   2263 O O     . GLU E 1 37 ? -5.639  34.998  15.322 1.00 16.05 ? 37  GLU E O     1 
ATOM   2264 C CB    . GLU E 1 37 ? -4.147  34.600  18.123 1.00 19.80 ? 37  GLU E CB    1 
ATOM   2265 C CG    . GLU E 1 37 ? -3.498  35.910  18.529 1.00 36.72 ? 37  GLU E CG    1 
ATOM   2266 C CD    . GLU E 1 37 ? -1.985  35.979  18.373 1.00 53.48 ? 37  GLU E CD    1 
ATOM   2267 O OE1   . GLU E 1 37 ? -1.491  36.992  17.848 1.00 49.55 ? 37  GLU E OE1   1 
ATOM   2268 O OE2   . GLU E 1 37 ? -1.295  35.032  18.783 1.00 45.21 ? 37  GLU E OE2   1 
ATOM   2269 N N     . SER E 1 38 ? -5.851  32.872  16.037 1.00 27.47 ? 38  SER E N     1 
ATOM   2270 C CA    . SER E 1 38 ? -5.866  32.298  14.698 1.00 12.81 ? 38  SER E CA    1 
ATOM   2271 C C     . SER E 1 38 ? -6.279  30.837  14.811 1.00 15.19 ? 38  SER E C     1 
ATOM   2272 O O     . SER E 1 38 ? -6.354  30.275  15.907 1.00 8.44  ? 38  SER E O     1 
ATOM   2273 C CB    . SER E 1 38 ? -4.502  32.434  14.018 1.00 21.84 ? 38  SER E CB    1 
ATOM   2274 O OG    . SER E 1 38 ? -3.466  31.949  14.855 1.00 38.06 ? 38  SER E OG    1 
ATOM   2275 N N     . PHE E 1 39 ? -6.546  30.227  13.659 1.00 15.07 ? 39  PHE E N     1 
ATOM   2276 C CA    . PHE E 1 39 ? -6.999  28.844  13.623 1.00 14.82 ? 39  PHE E CA    1 
ATOM   2277 C C     . PHE E 1 39 ? -6.842  28.307  12.210 1.00 25.48 ? 39  PHE E C     1 
ATOM   2278 O O     . PHE E 1 39 ? -6.719  29.068  11.247 1.00 8.09  ? 39  PHE E O     1 
ATOM   2279 C CB    . PHE E 1 39 ? -8.455  28.721  14.090 1.00 15.86 ? 39  PHE E CB    1 
ATOM   2280 C CG    . PHE E 1 39 ? -9.441  29.431  13.203 1.00 20.12 ? 39  PHE E CG    1 
ATOM   2281 C CD1   . PHE E 1 39 ? -9.913  28.833  12.046 1.00 24.91 ? 39  PHE E CD1   1 
ATOM   2282 C CD2   . PHE E 1 39 ? -9.894  30.698  13.529 1.00 34.34 ? 39  PHE E CD2   1 
ATOM   2283 C CE1   . PHE E 1 39 ? -10.818 29.486  11.232 1.00 34.71 ? 39  PHE E CE1   1 
ATOM   2284 C CE2   . PHE E 1 39 ? -10.798 31.355  12.719 1.00 31.98 ? 39  PHE E CE2   1 
ATOM   2285 C CZ    . PHE E 1 39 ? -11.261 30.749  11.569 1.00 31.17 ? 39  PHE E CZ    1 
ATOM   2286 N N     . ASP E 1 40 ? -6.843  26.982  12.103 1.00 12.47 ? 40  ASP E N     1 
ATOM   2287 C CA    . ASP E 1 40 ? -6.810  26.302  10.815 1.00 15.39 ? 40  ASP E CA    1 
ATOM   2288 C C     . ASP E 1 40 ? -7.614  25.012  10.951 1.00 20.89 ? 40  ASP E C     1 
ATOM   2289 O O     . ASP E 1 40 ? -8.332  24.810  11.935 1.00 20.17 ? 40  ASP E O     1 
ATOM   2290 C CB    . ASP E 1 40 ? -5.359  26.089  10.359 1.00 22.99 ? 40  ASP E CB    1 
ATOM   2291 C CG    . ASP E 1 40 ? -4.752  24.797  10.876 1.00 27.61 ? 40  ASP E CG    1 
ATOM   2292 O OD1   . ASP E 1 40 ? -5.203  24.285  11.921 1.00 25.35 ? 40  ASP E OD1   1 
ATOM   2293 O OD2   . ASP E 1 40 ? -3.810  24.293  10.230 1.00 31.29 ? 40  ASP E OD2   1 
ATOM   2294 N N     . GLN E 1 41 ? -7.484  24.127  9.960  1.00 24.90 ? 41  GLN E N     1 
ATOM   2295 C CA    . GLN E 1 41 ? -8.360  22.961  9.897  1.00 27.62 ? 41  GLN E CA    1 
ATOM   2296 C C     . GLN E 1 41 ? -8.290  22.124  11.169 1.00 21.04 ? 41  GLN E C     1 
ATOM   2297 O O     . GLN E 1 41 ? -9.300  21.550  11.594 1.00 14.84 ? 41  GLN E O     1 
ATOM   2298 C CB    . GLN E 1 41 ? -8.005  22.098  8.687  1.00 29.29 ? 41  GLN E CB    1 
ATOM   2299 C CG    . GLN E 1 41 ? -8.876  20.856  8.557  1.00 31.93 ? 41  GLN E CG    1 
ATOM   2300 C CD    . GLN E 1 41 ? -8.784  20.213  7.188  1.00 38.96 ? 41  GLN E CD    1 
ATOM   2301 O OE1   . GLN E 1 41 ? -8.188  20.771  6.268  1.00 53.97 ? 41  GLN E OE1   1 
ATOM   2302 N NE2   . GLN E 1 41 ? -9.372  19.031  7.049  1.00 36.02 ? 41  GLN E NE2   1 
ATOM   2303 N N     . PHE E 1 42 ? -7.112  22.031  11.790 1.00 20.88 ? 42  PHE E N     1 
ATOM   2304 C CA    . PHE E 1 42 ? -6.928  21.121  12.910 1.00 22.39 ? 42  PHE E CA    1 
ATOM   2305 C C     . PHE E 1 42 ? -6.512  21.776  14.220 1.00 14.41 ? 42  PHE E C     1 
ATOM   2306 O O     . PHE E 1 42 ? -6.511  21.089  15.248 1.00 13.73 ? 42  PHE E O     1 
ATOM   2307 C CB    . PHE E 1 42 ? -5.884  20.046  12.562 1.00 25.90 ? 42  PHE E CB    1 
ATOM   2308 C CG    . PHE E 1 42 ? -6.049  19.457  11.192 1.00 31.08 ? 42  PHE E CG    1 
ATOM   2309 C CD1   . PHE E 1 42 ? -6.978  18.455  10.963 1.00 31.21 ? 42  PHE E CD1   1 
ATOM   2310 C CD2   . PHE E 1 42 ? -5.271  19.897  10.136 1.00 21.90 ? 42  PHE E CD2   1 
ATOM   2311 C CE1   . PHE E 1 42 ? -7.131  17.906  9.705  1.00 30.31 ? 42  PHE E CE1   1 
ATOM   2312 C CE2   . PHE E 1 42 ? -5.418  19.353  8.876  1.00 41.42 ? 42  PHE E CE2   1 
ATOM   2313 C CZ    . PHE E 1 42 ? -6.350  18.356  8.659  1.00 37.61 ? 42  PHE E CZ    1 
ATOM   2314 N N     . VAL E 1 43 ? -6.166  23.066  14.235 1.00 11.32 ? 43  VAL E N     1 
ATOM   2315 C CA    . VAL E 1 43 ? -5.683  23.700  15.454 1.00 17.70 ? 43  VAL E CA    1 
ATOM   2316 C C     . VAL E 1 43 ? -6.267  25.098  15.605 1.00 18.39 ? 43  VAL E C     1 
ATOM   2317 O O     . VAL E 1 43 ? -6.687  25.737  14.638 1.00 11.41 ? 43  VAL E O     1 
ATOM   2318 C CB    . VAL E 1 43 ? -4.137  23.785  15.502 1.00 16.71 ? 43  VAL E CB    1 
ATOM   2319 C CG1   . VAL E 1 43 ? -3.515  22.407  15.311 1.00 18.51 ? 43  VAL E CG1   1 
ATOM   2320 C CG2   . VAL E 1 43 ? -3.619  24.777  14.463 1.00 18.60 ? 43  VAL E CG2   1 
ATOM   2321 N N     . ILE E 1 44 ? -6.282  25.561  16.854 1.00 12.47 ? 44  ILE E N     1 
ATOM   2322 C CA    . ILE E 1 44 ? -6.611  26.936  17.204 1.00 13.00 ? 44  ILE E CA    1 
ATOM   2323 C C     . ILE E 1 44 ? -5.465  27.483  18.042 1.00 14.66 ? 44  ILE E C     1 
ATOM   2324 O O     . ILE E 1 44 ? -5.060  26.858  19.028 1.00 15.72 ? 44  ILE E O     1 
ATOM   2325 C CB    . ILE E 1 44 ? -7.936  27.036  17.983 1.00 21.11 ? 44  ILE E CB    1 
ATOM   2326 C CG1   . ILE E 1 44 ? -9.119  26.685  17.079 1.00 18.69 ? 44  ILE E CG1   1 
ATOM   2327 C CG2   . ILE E 1 44 ? -8.096  28.430  18.572 1.00 14.74 ? 44  ILE E CG2   1 
ATOM   2328 C CD1   . ILE E 1 44 ? -10.391 26.365  17.841 1.00 13.74 ? 44  ILE E CD1   1 
ATOM   2329 N N     . LEU E 1 45 ? -4.917  28.628  17.669 1.00 16.25 ? 45  LEU E N     1 
ATOM   2330 C CA    . LEU E 1 45 ? -3.827  29.293  18.415 1.00 12.67 ? 45  LEU E CA    1 
ATOM   2331 C C     . LEU E 1 45 ? -4.452  30.241  19.431 1.00 12.36 ? 45  LEU E C     1 
ATOM   2332 O O     . LEU E 1 45 ? -5.076  31.226  19.012 1.00 17.45 ? 45  LEU E O     1 
ATOM   2333 C CB    . LEU E 1 45 ? -2.889  30.000  17.438 1.00 11.31 ? 45  LEU E CB    1 
ATOM   2334 C CG    . LEU E 1 45 ? -1.409  29.706  17.647 1.00 21.70 ? 45  LEU E CG    1 
ATOM   2335 C CD1   . LEU E 1 45 ? -1.104  28.280  17.245 1.00 32.38 ? 45  LEU E CD1   1 
ATOM   2336 C CD2   . LEU E 1 45 ? -0.533  30.665  16.869 1.00 42.71 ? 45  LEU E CD2   1 
ATOM   2337 N N     . LEU E 1 46 ? -4.361  29.893  20.699 1.00 13.41 ? 46  LEU E N     1 
ATOM   2338 C CA    . LEU E 1 46 ? -4.897  30.703  21.815 1.00 6.69  ? 46  LEU E CA    1 
ATOM   2339 C C     . LEU E 1 46 ? -3.761  31.566  22.357 1.00 16.97 ? 46  LEU E C     1 
ATOM   2340 O O     . LEU E 1 46 ? -2.617  31.141  22.267 1.00 14.04 ? 46  LEU E O     1 
ATOM   2341 C CB    . LEU E 1 46 ? -5.459  29.775  22.893 1.00 7.27  ? 46  LEU E CB    1 
ATOM   2342 C CG    . LEU E 1 46 ? -5.960  30.447  24.172 1.00 20.55 ? 46  LEU E CG    1 
ATOM   2343 C CD1   . LEU E 1 46 ? -7.286  31.146  23.937 1.00 20.48 ? 46  LEU E CD1   1 
ATOM   2344 C CD2   . LEU E 1 46 ? -6.088  29.448  25.305 1.00 9.50  ? 46  LEU E CD2   1 
ATOM   2345 N N     . LYS E 1 47 ? -4.092  32.707  22.949 1.00 23.56 ? 47  LYS E N     1 
ATOM   2346 C CA    . LYS E 1 47 ? -3.074  33.661  23.449 1.00 33.92 ? 47  LYS E CA    1 
ATOM   2347 C C     . LYS E 1 47 ? -3.303  34.150  24.881 1.00 17.72 ? 47  LYS E C     1 
ATOM   2348 O O     . LYS E 1 47 ? -4.446  34.335  25.285 1.00 14.19 ? 47  LYS E O     1 
ATOM   2349 C CB    . LYS E 1 47 ? -3.039  34.870  22.519 1.00 28.12 ? 47  LYS E CB    1 
ATOM   2350 C CG    . LYS E 1 47 ? -1.718  35.089  21.797 1.00 50.41 ? 47  LYS E CG    1 
ATOM   2351 C CD    . LYS E 1 47 ? -0.595  35.589  22.677 1.00 50.23 ? 47  LYS E CD    1 
ATOM   2352 C CE    . LYS E 1 47 ? 0.759   35.473  22.010 1.00 53.79 ? 47  LYS E CE    1 
ATOM   2353 N NZ    . LYS E 1 47 ? 1.643   36.612  22.339 1.00 57.72 ? 47  LYS E NZ    1 
ATOM   2354 N N     . ASN E 1 48 ? -2.230  34.284  25.609 1.00 16.99 ? 48  ASN E N     1 
ATOM   2355 C CA    . ASN E 1 48 ? -2.239  34.934  26.915 1.00 47.28 ? 48  ASN E CA    1 
ATOM   2356 C C     . ASN E 1 48 ? -0.840  35.501  27.144 1.00 55.48 ? 48  ASN E C     1 
ATOM   2357 O O     . ASN E 1 48 ? -0.412  36.394  26.409 1.00 47.48 ? 48  ASN E O     1 
ATOM   2358 C CB    . ASN E 1 48 ? -2.676  33.953  27.995 1.00 44.82 ? 48  ASN E CB    1 
ATOM   2359 C CG    . ASN E 1 48 ? -3.571  34.597  29.029 1.00 58.26 ? 48  ASN E CG    1 
ATOM   2360 O OD1   . ASN E 1 48 ? -3.375  35.754  29.405 1.00 54.23 ? 48  ASN E OD1   1 
ATOM   2361 N ND2   . ASN E 1 48 ? -4.583  33.863  29.470 1.00 40.95 ? 48  ASN E ND2   1 
ATOM   2362 N N     . THR E 1 49 ? -0.101  35.001  28.132 1.00 62.43 ? 49  THR E N     1 
ATOM   2363 C CA    . THR E 1 49 ? 1.314   35.350  28.203 1.00 59.88 ? 49  THR E CA    1 
ATOM   2364 C C     . THR E 1 49 ? 2.078   34.826  26.992 1.00 51.32 ? 49  THR E C     1 
ATOM   2365 O O     . THR E 1 49 ? 3.075   35.428  26.576 1.00 41.74 ? 49  THR E O     1 
ATOM   2366 C CB    . THR E 1 49 ? 1.932   34.792  29.481 1.00 56.14 ? 49  THR E CB    1 
ATOM   2367 O OG1   . THR E 1 49 ? 1.449   35.514  30.618 1.00 70.89 ? 49  THR E OG1   1 
ATOM   2368 C CG2   . THR E 1 49 ? 3.446   34.885  29.443 1.00 74.30 ? 49  THR E CG2   1 
ATOM   2369 N N     . VAL E 1 50 ? 1.632   33.707  26.417 1.00 40.83 ? 50  VAL E N     1 
ATOM   2370 C CA    . VAL E 1 50 ? 2.246   33.115  25.237 1.00 36.45 ? 50  VAL E CA    1 
ATOM   2371 C C     . VAL E 1 50 ? 1.135   32.544  24.367 1.00 12.27 ? 50  VAL E C     1 
ATOM   2372 O O     . VAL E 1 50 ? 0.014   32.318  24.825 1.00 13.88 ? 50  VAL E O     1 
ATOM   2373 C CB    . VAL E 1 50 ? 3.270   32.015  25.596 1.00 45.87 ? 50  VAL E CB    1 
ATOM   2374 C CG1   . VAL E 1 50 ? 4.316   32.554  26.555 1.00 22.57 ? 50  VAL E CG1   1 
ATOM   2375 C CG2   . VAL E 1 50 ? 2.576   30.819  26.220 1.00 30.71 ? 50  VAL E CG2   1 
ATOM   2376 N N     . SER E 1 51 ? 1.465   32.303  23.099 1.00 27.37 ? 51  SER E N     1 
ATOM   2377 C CA    . SER E 1 51 ? 0.515   31.771  22.124 1.00 29.86 ? 51  SER E CA    1 
ATOM   2378 C C     . SER E 1 51 ? 0.666   30.254  22.076 1.00 35.26 ? 51  SER E C     1 
ATOM   2379 O O     . SER E 1 51 ? 1.559   29.730  21.406 1.00 18.59 ? 51  SER E O     1 
ATOM   2380 C CB    . SER E 1 51 ? 0.753   32.394  20.754 1.00 22.99 ? 51  SER E CB    1 
ATOM   2381 O OG    . SER E 1 51 ? 0.015   31.708  19.765 1.00 37.40 ? 51  SER E OG    1 
ATOM   2382 N N     . GLN E 1 52 ? -0.208  29.545  22.787 1.00 23.91 ? 52  GLN E N     1 
ATOM   2383 C CA    . GLN E 1 52 ? -0.185  28.090  22.806 1.00 13.63 ? 52  GLN E CA    1 
ATOM   2384 C C     . GLN E 1 52 ? -1.078  27.538  21.706 1.00 17.02 ? 52  GLN E C     1 
ATOM   2385 O O     . GLN E 1 52 ? -2.091  28.141  21.341 1.00 7.33  ? 52  GLN E O     1 
ATOM   2386 C CB    . GLN E 1 52 ? -0.643  27.547  24.161 1.00 6.67  ? 52  GLN E CB    1 
ATOM   2387 C CG    . GLN E 1 52 ? -2.126  27.725  24.441 1.00 5.18  ? 52  GLN E CG    1 
ATOM   2388 C CD    . GLN E 1 52 ? -2.433  27.753  25.927 1.00 19.74 ? 52  GLN E CD    1 
ATOM   2389 O OE1   . GLN E 1 52 ? -2.731  26.722  26.529 1.00 24.10 ? 52  GLN E OE1   1 
ATOM   2390 N NE2   . GLN E 1 52 ? -2.360  28.936  26.526 1.00 31.15 ? 52  GLN E NE2   1 
ATOM   2391 N N     . MET E 1 53 ? -0.694  26.375  21.186 1.00 17.48 ? 53  MET E N     1 
ATOM   2392 C CA    . MET E 1 53 ? -1.403  25.726  20.091 1.00 16.46 ? 53  MET E CA    1 
ATOM   2393 C C     . MET E 1 53 ? -2.294  24.627  20.656 1.00 22.73 ? 53  MET E C     1 
ATOM   2394 O O     . MET E 1 53 ? -1.804  23.698  21.307 1.00 11.11 ? 53  MET E O     1 
ATOM   2395 C CB    . MET E 1 53 ? -0.416  25.149  19.074 1.00 13.64 ? 53  MET E CB    1 
ATOM   2396 C CG    . MET E 1 53 ? -1.030  24.876  17.712 1.00 17.71 ? 53  MET E CG    1 
ATOM   2397 S SD    . MET E 1 53 ? -0.039  23.888  16.568 1.00 18.17 ? 53  MET E SD    1 
ATOM   2398 C CE    . MET E 1 53 ? 0.948   22.867  17.660 1.00 11.25 ? 53  MET E CE    1 
ATOM   2399 N N     . VAL E 1 54 ? -3.594  24.726  20.393 1.00 22.64 ? 54  VAL E N     1 
ATOM   2400 C CA    . VAL E 1 54 ? -4.581  23.775  20.890 1.00 13.73 ? 54  VAL E CA    1 
ATOM   2401 C C     . VAL E 1 54 ? -5.121  22.979  19.711 1.00 9.11  ? 54  VAL E C     1 
ATOM   2402 O O     . VAL E 1 54 ? -5.599  23.558  18.728 1.00 9.51  ? 54  VAL E O     1 
ATOM   2403 C CB    . VAL E 1 54 ? -5.722  24.485  21.639 1.00 16.86 ? 54  VAL E CB    1 
ATOM   2404 C CG1   . VAL E 1 54 ? -6.432  23.511  22.566 1.00 23.00 ? 54  VAL E CG1   1 
ATOM   2405 C CG2   . VAL E 1 54 ? -5.186  25.680  22.414 1.00 6.15  ? 54  VAL E CG2   1 
ATOM   2406 N N     . TYR E 1 55 ? -5.040  21.655  19.808 1.00 7.62  ? 55  TYR E N     1 
ATOM   2407 C CA    . TYR E 1 55 ? -5.585  20.784  18.777 1.00 19.57 ? 55  TYR E CA    1 
ATOM   2408 C C     . TYR E 1 55 ? -7.099  20.695  18.913 1.00 11.59 ? 55  TYR E C     1 
ATOM   2409 O O     . TYR E 1 55 ? -7.633  20.548  20.017 1.00 8.35  ? 55  TYR E O     1 
ATOM   2410 C CB    . TYR E 1 55 ? -4.966  19.390  18.873 1.00 18.30 ? 55  TYR E CB    1 
ATOM   2411 C CG    . TYR E 1 55 ? -3.585  19.301  18.265 1.00 25.22 ? 55  TYR E CG    1 
ATOM   2412 C CD1   . TYR E 1 55 ? -3.416  19.163  16.895 1.00 20.72 ? 55  TYR E CD1   1 
ATOM   2413 C CD2   . TYR E 1 55 ? -2.450  19.358  19.062 1.00 22.73 ? 55  TYR E CD2   1 
ATOM   2414 C CE1   . TYR E 1 55 ? -2.156  19.084  16.335 1.00 30.62 ? 55  TYR E CE1   1 
ATOM   2415 C CE2   . TYR E 1 55 ? -1.186  19.279  18.511 1.00 25.79 ? 55  TYR E CE2   1 
ATOM   2416 C CZ    . TYR E 1 55 ? -1.045  19.141  17.148 1.00 15.81 ? 55  TYR E CZ    1 
ATOM   2417 O OH    . TYR E 1 55 ? 0.211   19.063  16.594 1.00 20.83 ? 55  TYR E OH    1 
ATOM   2418 N N     . LYS E 1 56 ? -7.793  20.785  17.777 1.00 12.09 ? 56  LYS E N     1 
ATOM   2419 C CA    . LYS E 1 56 ? -9.252  20.763  17.805 1.00 14.97 ? 56  LYS E CA    1 
ATOM   2420 C C     . LYS E 1 56 ? -9.777  19.437  18.342 1.00 20.91 ? 56  LYS E C     1 
ATOM   2421 O O     . LYS E 1 56 ? -10.789 19.405  19.052 1.00 14.20 ? 56  LYS E O     1 
ATOM   2422 C CB    . LYS E 1 56 ? -9.806  21.029  16.406 1.00 10.19 ? 56  LYS E CB    1 
ATOM   2423 C CG    . LYS E 1 56 ? -9.807  22.495  16.000 1.00 8.51  ? 56  LYS E CG    1 
ATOM   2424 C CD    . LYS E 1 56 ? -9.869  22.638  14.486 1.00 30.68 ? 56  LYS E CD    1 
ATOM   2425 C CE    . LYS E 1 56 ? -10.472 23.970  14.069 1.00 15.67 ? 56  LYS E CE    1 
ATOM   2426 N NZ    . LYS E 1 56 ? -11.024 23.923  12.684 1.00 24.48 ? 56  LYS E NZ    1 
ATOM   2427 N N     . HIS E 1 57 ? -9.099  18.330  18.021 1.00 13.23 ? 57  HIS E N     1 
ATOM   2428 C CA    . HIS E 1 57 ? -9.598  17.019  18.423 1.00 12.82 ? 57  HIS E CA    1 
ATOM   2429 C C     . HIS E 1 57 ? -9.677  16.867  19.936 1.00 8.56  ? 57  HIS E C     1 
ATOM   2430 O O     . HIS E 1 57 ? -10.356 15.954  20.419 1.00 2.87  ? 57  HIS E O     1 
ATOM   2431 C CB    . HIS E 1 57 ? -8.720  15.909  17.829 1.00 5.26  ? 57  HIS E CB    1 
ATOM   2432 C CG    . HIS E 1 57 ? -7.292  15.946  18.280 1.00 6.04  ? 57  HIS E CG    1 
ATOM   2433 N ND1   . HIS E 1 57 ? -6.241  16.111  17.402 1.00 1.43  ? 57  HIS E ND1   1 
ATOM   2434 C CD2   . HIS E 1 57 ? -6.737  15.817  19.508 1.00 21.37 ? 57  HIS E CD2   1 
ATOM   2435 C CE1   . HIS E 1 57 ? -5.103  16.097  18.072 1.00 21.03 ? 57  HIS E CE1   1 
ATOM   2436 N NE2   . HIS E 1 57 ? -5.376  15.921  19.352 1.00 11.47 ? 57  HIS E NE2   1 
ATOM   2437 N N     . ALA E 1 58 ? -9.012  17.738  20.694 1.00 13.02 ? 58  ALA E N     1 
ATOM   2438 C CA    . ALA E 1 58 ? -9.020  17.670  22.148 1.00 11.96 ? 58  ALA E CA    1 
ATOM   2439 C C     . ALA E 1 58 ? -9.908  18.726  22.792 1.00 7.65  ? 58  ALA E C     1 
ATOM   2440 O O     . ALA E 1 58 ? -9.981  18.787  24.025 1.00 7.96  ? 58  ALA E O     1 
ATOM   2441 C CB    . ALA E 1 58 ? -7.593  17.803  22.691 1.00 18.38 ? 58  ALA E CB    1 
ATOM   2442 N N     . ILE E 1 59 ? -10.575 19.556  22.002 1.00 4.98  ? 59  ILE E N     1 
ATOM   2443 C CA    . ILE E 1 59 ? -11.504 20.551  22.523 1.00 14.01 ? 59  ILE E CA    1 
ATOM   2444 C C     . ILE E 1 59 ? -12.910 19.973  22.492 1.00 14.88 ? 59  ILE E C     1 
ATOM   2445 O O     . ILE E 1 59 ? -13.289 19.270  21.548 1.00 12.65 ? 59  ILE E O     1 
ATOM   2446 C CB    . ILE E 1 59 ? -11.433 21.858  21.712 1.00 35.00 ? 59  ILE E CB    1 
ATOM   2447 C CG1   . ILE E 1 59 ? -10.021 22.443  21.741 1.00 15.86 ? 59  ILE E CG1   1 
ATOM   2448 C CG2   . ILE E 1 59 ? -12.445 22.863  22.247 1.00 26.91 ? 59  ILE E CG2   1 
ATOM   2449 C CD1   . ILE E 1 59 ? -9.696  23.291  20.528 1.00 10.39 ? 59  ILE E CD1   1 
ATOM   2450 N N     . SER E 1 60 ? -13.692 20.271  23.526 1.00 14.01 ? 60  SER E N     1 
ATOM   2451 C CA    . SER E 1 60 ? -15.106 19.921  23.539 1.00 24.56 ? 60  SER E CA    1 
ATOM   2452 C C     . SER E 1 60 ? -16.006 21.114  23.250 1.00 16.61 ? 60  SER E C     1 
ATOM   2453 O O     . SER E 1 60 ? -16.988 20.975  22.515 1.00 22.68 ? 60  SER E O     1 
ATOM   2454 C CB    . SER E 1 60 ? -15.494 19.304  24.886 1.00 19.24 ? 60  SER E CB    1 
ATOM   2455 O OG    . SER E 1 60 ? -15.028 20.089  25.967 1.00 24.24 ? 60  SER E OG    1 
ATOM   2456 N N     . THR E 1 61 ? -15.649 22.277  23.788 1.00 13.39 ? 61  THR E N     1 
ATOM   2457 C CA    . THR E 1 61 ? -16.436 23.518  23.595 1.00 24.20 ? 61  THR E CA    1 
ATOM   2458 C C     . THR E 1 61 ? -15.572 24.773  23.475 1.00 25.48 ? 61  THR E C     1 
ATOM   2459 O O     . THR E 1 61 ? -14.458 24.797  24.025 1.00 15.94 ? 61  THR E O     1 
ATOM   2460 C CB    . THR E 1 61 ? -17.448 23.748  24.727 1.00 17.55 ? 61  THR E CB    1 
ATOM   2461 O OG1   . THR E 1 61 ? -16.782 24.185  25.908 1.00 18.07 ? 61  THR E OG1   1 
ATOM   2462 C CG2   . THR E 1 61 ? -18.261 22.510  25.045 1.00 10.91 ? 61  THR E CG2   1 
ATOM   2463 N N     . VAL E 1 62 ? -16.103 25.768  22.782 1.00 27.52 ? 62  VAL E N     1 
ATOM   2464 C CA    . VAL E 1 62 ? -15.492 27.113  22.660 1.00 29.12 ? 62  VAL E CA    1 
ATOM   2465 C C     . VAL E 1 62 ? -16.613 28.057  23.109 1.00 28.98 ? 62  VAL E C     1 
ATOM   2466 O O     . VAL E 1 62 ? -17.616 28.154  22.397 1.00 17.49 ? 62  VAL E O     1 
ATOM   2467 C CB    . VAL E 1 62 ? -14.997 27.400  21.240 1.00 12.87 ? 62  VAL E CB    1 
ATOM   2468 C CG1   . VAL E 1 62 ? -14.445 28.805  21.119 1.00 41.13 ? 62  VAL E CG1   1 
ATOM   2469 C CG2   . VAL E 1 62 ? -13.973 26.379  20.784 1.00 30.94 ? 62  VAL E CG2   1 
ATOM   2470 N N     . VAL E 1 63 ? -16.454 28.672  24.266 1.00 25.55 ? 63  VAL E N     1 
ATOM   2471 C CA    . VAL E 1 63 ? -17.494 29.541  24.865 1.00 31.45 ? 63  VAL E CA    1 
ATOM   2472 C C     . VAL E 1 63 ? -17.007 30.995  24.982 1.00 31.19 ? 63  VAL E C     1 
ATOM   2473 O O     . VAL E 1 63 ? -15.998 31.240  25.636 1.00 13.30 ? 63  VAL E O     1 
ATOM   2474 C CB    . VAL E 1 63 ? -17.928 29.007  26.235 1.00 29.31 ? 63  VAL E CB    1 
ATOM   2475 C CG1   . VAL E 1 63 ? -16.755 28.625  27.114 1.00 32.81 ? 63  VAL E CG1   1 
ATOM   2476 C CG2   . VAL E 1 63 ? -18.850 29.995  26.924 1.00 35.42 ? 63  VAL E CG2   1 
ATOM   2477 N N     . PRO E 1 64 ? -17.743 31.964  24.394 1.00 34.15 ? 64  PRO E N     1 
ATOM   2478 C CA    . PRO E 1 64 ? -17.416 33.377  24.565 1.00 30.92 ? 64  PRO E CA    1 
ATOM   2479 C C     . PRO E 1 64 ? -17.631 33.831  26.011 1.00 17.13 ? 64  PRO E C     1 
ATOM   2480 O O     . PRO E 1 64 ? -18.518 33.312  26.615 1.00 23.55 ? 64  PRO E O     1 
ATOM   2481 C CB    . PRO E 1 64 ? -18.367 34.119  23.641 1.00 20.96 ? 64  PRO E CB    1 
ATOM   2482 C CG    . PRO E 1 64 ? -18.934 33.064  22.724 1.00 40.06 ? 64  PRO E CG    1 
ATOM   2483 C CD    . PRO E 1 64 ? -18.877 31.769  23.499 1.00 30.83 ? 64  PRO E CD    1 
ATOM   2484 N N     . SER E 1 65 ? -16.787 34.710  26.519 1.00 9.64  ? 65  SER E N     1 
ATOM   2485 C CA    . SER E 1 65 ? -16.893 35.322  27.866 1.00 13.44 ? 65  SER E CA    1 
ATOM   2486 C C     . SER E 1 65 ? -18.214 36.062  28.011 1.00 28.12 ? 65  SER E C     1 
ATOM   2487 O O     . SER E 1 65 ? -18.695 36.195  29.150 1.00 36.88 ? 65  SER E O     1 
ATOM   2488 C CB    . SER E 1 65 ? -15.782 36.314  28.027 1.00 30.86 ? 65  SER E CB    1 
ATOM   2489 O OG    . SER E 1 65 ? -15.772 37.247  26.961 1.00 15.22 ? 65  SER E OG    1 
ATOM   2490 N N     . ARG E 1 66 ? -18.751 36.553  26.904 1.00 22.60 ? 66  ARG E N     1 
ATOM   2491 C CA    . ARG E 1 66 ? -19.995 37.334  26.892 1.00 35.23 ? 66  ARG E CA    1 
ATOM   2492 C C     . ARG E 1 66 ? -20.622 37.182  25.508 1.00 32.21 ? 66  ARG E C     1 
ATOM   2493 O O     . ARG E 1 66 ? -19.902 36.829  24.585 1.00 47.46 ? 66  ARG E O     1 
ATOM   2494 C CB    . ARG E 1 66 ? -19.645 38.785  27.212 1.00 30.76 ? 66  ARG E CB    1 
ATOM   2495 C CG    . ARG E 1 66 ? -18.809 39.453  26.129 1.00 31.80 ? 66  ARG E CG    1 
ATOM   2496 C CD    . ARG E 1 66 ? -17.566 40.122  26.675 1.00 37.13 ? 66  ARG E CD    1 
ATOM   2497 N NE    . ARG E 1 66 ? -17.196 41.293  25.899 1.00 48.37 ? 66  ARG E NE    1 
ATOM   2498 C CZ    . ARG E 1 66 ? -15.991 41.506  25.385 1.00 32.60 ? 66  ARG E CZ    1 
ATOM   2499 N NH1   . ARG E 1 66 ? -14.912 41.314  26.120 1.00 37.02 ? 66  ARG E NH1   1 
ATOM   2500 N NH2   . ARG E 1 66 ? -15.870 41.901  24.132 1.00 36.26 ? 66  ARG E NH2   1 
ATOM   2501 N N     . PRO E 1 67 ? -21.909 37.498  25.326 1.00 36.15 ? 67  PRO E N     1 
ATOM   2502 C CA    . PRO E 1 67 ? -22.585 37.305  24.037 1.00 46.61 ? 67  PRO E CA    1 
ATOM   2503 C C     . PRO E 1 67 ? -21.860 38.015  22.900 1.00 42.28 ? 67  PRO E C     1 
ATOM   2504 O O     . PRO E 1 67 ? -21.167 39.015  23.100 1.00 63.78 ? 67  PRO E O     1 
ATOM   2505 C CB    . PRO E 1 67 ? -23.983 37.888  24.275 1.00 43.14 ? 67  PRO E CB    1 
ATOM   2506 C CG    . PRO E 1 67 ? -24.183 37.770  25.762 1.00 30.57 ? 67  PRO E CG    1 
ATOM   2507 C CD    . PRO E 1 67 ? -22.824 38.038  26.353 1.00 46.22 ? 67  PRO E CD    1 
ATOM   2508 N N     . VAL E 1 68 ? -22.022 37.472  21.692 1.00 51.85 ? 68  VAL E N     1 
ATOM   2509 C CA    . VAL E 1 68 ? -21.322 37.953  20.503 1.00 47.33 ? 68  VAL E CA    1 
ATOM   2510 C C     . VAL E 1 68 ? -22.149 37.568  19.281 1.00 60.24 ? 68  VAL E C     1 
ATOM   2511 O O     . VAL E 1 68 ? -23.115 36.805  19.392 1.00 64.61 ? 68  VAL E O     1 
ATOM   2512 C CB    . VAL E 1 68 ? -19.893 37.376  20.437 1.00 47.16 ? 68  VAL E CB    1 
ATOM   2513 C CG1   . VAL E 1 68 ? -19.932 35.852  20.459 1.00 51.46 ? 68  VAL E CG1   1 
ATOM   2514 C CG2   . VAL E 1 68 ? -19.139 37.881  19.211 1.00 56.95 ? 68  VAL E CG2   1 
ATOM   2515 N N     . GLN F 1 5  ? -28.318 6.960   4.448  1.00 64.73 ? 5   GLN F N     1 
ATOM   2516 C CA    . GLN F 1 5  ? -29.312 7.976   4.773  1.00 78.79 ? 5   GLN F CA    1 
ATOM   2517 C C     . GLN F 1 5  ? -29.053 8.531   6.171  1.00 61.61 ? 5   GLN F C     1 
ATOM   2518 O O     . GLN F 1 5  ? -28.973 7.782   7.145  1.00 58.02 ? 5   GLN F O     1 
ATOM   2519 C CB    . GLN F 1 5  ? -30.721 7.395   4.675  1.00 84.40 ? 5   GLN F CB    1 
ATOM   2520 C CG    . GLN F 1 5  ? -31.104 6.969   3.263  1.00 72.24 ? 5   GLN F CG    1 
ATOM   2521 C CD    . GLN F 1 5  ? -30.865 8.060   2.234  1.00 77.42 ? 5   GLN F CD    1 
ATOM   2522 O OE1   . GLN F 1 5  ? -31.329 9.189   2.391  1.00 67.64 ? 5   GLN F OE1   1 
ATOM   2523 N NE2   . GLN F 1 5  ? -30.126 7.730   1.181  1.00 74.63 ? 5   GLN F NE2   1 
ATOM   2524 N N     . SER F 1 6  ? -28.927 9.853   6.259  1.00 58.09 ? 6   SER F N     1 
ATOM   2525 C CA    . SER F 1 6  ? -28.520 10.495  7.502  1.00 52.57 ? 6   SER F CA    1 
ATOM   2526 C C     . SER F 1 6  ? -29.653 10.462  8.521  1.00 42.27 ? 6   SER F C     1 
ATOM   2527 O O     . SER F 1 6  ? -30.755 10.954  8.255  1.00 30.47 ? 6   SER F O     1 
ATOM   2528 C CB    . SER F 1 6  ? -28.092 11.935  7.233  1.00 56.80 ? 6   SER F CB    1 
ATOM   2529 O OG    . SER F 1 6  ? -27.887 12.637  8.447  1.00 38.29 ? 6   SER F OG    1 
ATOM   2530 N N     . LEU F 1 7  ? -29.377 9.883   9.687  1.00 44.68 ? 7   LEU F N     1 
ATOM   2531 C CA    . LEU F 1 7  ? -30.283 9.923   10.826 1.00 41.53 ? 7   LEU F CA    1 
ATOM   2532 C C     . LEU F 1 7  ? -29.939 11.050  11.791 1.00 37.03 ? 7   LEU F C     1 
ATOM   2533 O O     . LEU F 1 7  ? -30.507 11.110  12.885 1.00 40.57 ? 7   LEU F O     1 
ATOM   2534 C CB    . LEU F 1 7  ? -30.245 8.589   11.577 1.00 39.23 ? 7   LEU F CB    1 
ATOM   2535 C CG    . LEU F 1 7  ? -31.529 8.049   12.213 1.00 31.62 ? 7   LEU F CG    1 
ATOM   2536 C CD1   . LEU F 1 7  ? -32.664 7.975   11.203 1.00 22.22 ? 7   LEU F CD1   1 
ATOM   2537 C CD2   . LEU F 1 7  ? -31.253 6.685   12.831 1.00 36.42 ? 7   LEU F CD2   1 
ATOM   2538 N N     . GLN F 1 8  ? -29.016 11.935  11.414 1.00 34.50 ? 8   GLN F N     1 
ATOM   2539 C CA    . GLN F 1 8  ? -28.452 12.932  12.316 1.00 14.03 ? 8   GLN F CA    1 
ATOM   2540 C C     . GLN F 1 8  ? -29.056 14.315  12.116 1.00 18.71 ? 8   GLN F C     1 
ATOM   2541 O O     . GLN F 1 8  ? -29.506 14.937  13.081 1.00 12.87 ? 8   GLN F O     1 
ATOM   2542 C CB    . GLN F 1 8  ? -26.933 12.989  12.117 1.00 18.56 ? 8   GLN F CB    1 
ATOM   2543 C CG    . GLN F 1 8  ? -26.222 14.160  12.773 1.00 30.33 ? 8   GLN F CG    1 
ATOM   2544 C CD    . GLN F 1 8  ? -24.767 13.843  13.094 1.00 31.35 ? 8   GLN F CD    1 
ATOM   2545 O OE1   . GLN F 1 8  ? -24.153 14.492  13.940 1.00 5.55  ? 8   GLN F OE1   1 
ATOM   2546 N NE2   . GLN F 1 8  ? -24.209 12.848  12.409 1.00 21.77 ? 8   GLN F NE2   1 
ATOM   2547 N N     . ASP F 1 9  ? -29.063 14.816  10.884 1.00 14.46 ? 9   ASP F N     1 
ATOM   2548 C CA    . ASP F 1 9  ? -29.714 16.097  10.625 1.00 29.15 ? 9   ASP F CA    1 
ATOM   2549 C C     . ASP F 1 9  ? -31.165 16.102  11.082 1.00 32.46 ? 9   ASP F C     1 
ATOM   2550 O O     . ASP F 1 9  ? -31.559 17.031  11.809 1.00 24.41 ? 9   ASP F O     1 
ATOM   2551 C CB    . ASP F 1 9  ? -29.605 16.443  9.137  1.00 38.14 ? 9   ASP F CB    1 
ATOM   2552 C CG    . ASP F 1 9  ? -28.202 16.261  8.598  1.00 30.58 ? 9   ASP F CG    1 
ATOM   2553 O OD1   . ASP F 1 9  ? -27.327 17.093  8.919  1.00 27.20 ? 9   ASP F OD1   1 
ATOM   2554 O OD2   . ASP F 1 9  ? -27.976 15.285  7.853  1.00 41.95 ? 9   ASP F OD2   1 
ATOM   2555 N N     . PRO F 1 10 ? -32.004 15.128  10.713 1.00 14.29 ? 10  PRO F N     1 
ATOM   2556 C CA    . PRO F 1 10 ? -33.409 15.182  11.157 1.00 20.83 ? 10  PRO F CA    1 
ATOM   2557 C C     . PRO F 1 10 ? -33.567 15.217  12.667 1.00 22.61 ? 10  PRO F C     1 
ATOM   2558 O O     . PRO F 1 10 ? -34.422 15.950  13.180 1.00 23.73 ? 10  PRO F O     1 
ATOM   2559 C CB    . PRO F 1 10 ? -34.024 13.911  10.546 1.00 24.55 ? 10  PRO F CB    1 
ATOM   2560 C CG    . PRO F 1 10 ? -32.861 13.045  10.165 1.00 23.40 ? 10  PRO F CG    1 
ATOM   2561 C CD    . PRO F 1 10 ? -31.748 13.985  9.821  1.00 29.84 ? 10  PRO F CD    1 
ATOM   2562 N N     . PHE F 1 11 ? -32.762 14.444  13.399 1.00 18.74 ? 11  PHE F N     1 
ATOM   2563 C CA    . PHE F 1 11 ? -32.874 14.431  14.853 1.00 22.80 ? 11  PHE F CA    1 
ATOM   2564 C C     . PHE F 1 11 ? -32.571 15.807  15.437 1.00 20.66 ? 11  PHE F C     1 
ATOM   2565 O O     . PHE F 1 11 ? -33.322 16.319  16.276 1.00 23.74 ? 11  PHE F O     1 
ATOM   2566 C CB    . PHE F 1 11 ? -31.931 13.379  15.438 1.00 18.75 ? 11  PHE F CB    1 
ATOM   2567 C CG    . PHE F 1 11 ? -32.022 13.250  16.932 1.00 12.13 ? 11  PHE F CG    1 
ATOM   2568 C CD1   . PHE F 1 11 ? -31.303 14.100  17.766 1.00 17.41 ? 11  PHE F CD1   1 
ATOM   2569 C CD2   . PHE F 1 11 ? -32.829 12.287  17.506 1.00 12.11 ? 11  PHE F CD2   1 
ATOM   2570 C CE1   . PHE F 1 11 ? -31.387 13.991  19.145 1.00 11.85 ? 11  PHE F CE1   1 
ATOM   2571 C CE2   . PHE F 1 11 ? -32.916 12.172  18.884 1.00 14.15 ? 11  PHE F CE2   1 
ATOM   2572 C CZ    . PHE F 1 11 ? -32.193 13.028  19.704 1.00 15.62 ? 11  PHE F CZ    1 
ATOM   2573 N N     . LEU F 1 12 ? -31.464 16.419  15.005 1.00 12.55 ? 12  LEU F N     1 
ATOM   2574 C CA    . LEU F 1 12 ? -31.090 17.730  15.523 1.00 15.09 ? 12  LEU F CA    1 
ATOM   2575 C C     . LEU F 1 12 ? -32.050 18.807  15.034 1.00 20.07 ? 12  LEU F C     1 
ATOM   2576 O O     . LEU F 1 12 ? -32.461 19.679  15.809 1.00 29.92 ? 12  LEU F O     1 
ATOM   2577 C CB    . LEU F 1 12 ? -29.656 18.072  15.109 1.00 24.40 ? 12  LEU F CB    1 
ATOM   2578 C CG    . LEU F 1 12 ? -28.488 17.448  15.879 1.00 16.93 ? 12  LEU F CG    1 
ATOM   2579 C CD1   . LEU F 1 12 ? -28.420 17.984  17.303 1.00 17.16 ? 12  LEU F CD1   1 
ATOM   2580 C CD2   . LEU F 1 12 ? -28.574 15.929  15.885 1.00 29.85 ? 12  LEU F CD2   1 
ATOM   2581 N N     . ASN F 1 13 ? -32.424 18.757  13.753 1.00 17.81 ? 13  ASN F N     1 
ATOM   2582 C CA    . ASN F 1 13 ? -33.296 19.785  13.193 1.00 26.68 ? 13  ASN F CA    1 
ATOM   2583 C C     . ASN F 1 13 ? -34.658 19.782  13.875 1.00 28.10 ? 13  ASN F C     1 
ATOM   2584 O O     . ASN F 1 13 ? -35.237 20.846  14.125 1.00 31.41 ? 13  ASN F O     1 
ATOM   2585 C CB    . ASN F 1 13 ? -33.450 19.578  11.686 1.00 40.07 ? 13  ASN F CB    1 
ATOM   2586 C CG    . ASN F 1 13 ? -32.484 20.427  10.876 1.00 49.92 ? 13  ASN F CG    1 
ATOM   2587 O OD1   . ASN F 1 13 ? -31.873 21.363  11.393 1.00 45.52 ? 13  ASN F OD1   1 
ATOM   2588 N ND2   . ASN F 1 13 ? -32.344 20.102  9.596  1.00 49.27 ? 13  ASN F ND2   1 
ATOM   2589 N N     . ALA F 1 14 ? -35.130 18.626  14.301 1.00 31.84 ? 14  ALA F N     1 
ATOM   2590 C CA    . ALA F 1 14 ? -36.414 18.511  15.011 1.00 35.94 ? 14  ALA F CA    1 
ATOM   2591 C C     . ALA F 1 14 ? -36.287 19.203  16.371 1.00 33.71 ? 14  ALA F C     1 
ATOM   2592 O O     . ALA F 1 14 ? -37.210 19.924  16.731 1.00 30.59 ? 14  ALA F O     1 
ATOM   2593 C CB    . ALA F 1 14 ? -36.804 17.068  15.098 1.00 24.59 ? 14  ALA F CB    1 
ATOM   2594 N N     . LEU F 1 15 ? -35.191 18.991  17.092 1.00 38.48 ? 15  LEU F N     1 
ATOM   2595 C CA    . LEU F 1 15 ? -34.917 19.659  18.388 1.00 26.61 ? 15  LEU F CA    1 
ATOM   2596 C C     . LEU F 1 15 ? -34.803 21.165  18.161 1.00 36.17 ? 15  LEU F C     1 
ATOM   2597 O O     . LEU F 1 15 ? -35.205 21.917  19.047 1.00 30.71 ? 15  LEU F O     1 
ATOM   2598 C CB    . LEU F 1 15 ? -33.618 19.097  18.964 1.00 33.04 ? 15  LEU F CB    1 
ATOM   2599 C CG    . LEU F 1 15 ? -33.791 17.954  19.962 1.00 32.06 ? 15  LEU F CG    1 
ATOM   2600 C CD1   . LEU F 1 15 ? -34.120 18.474  21.348 1.00 39.83 ? 15  LEU F CD1   1 
ATOM   2601 C CD2   . LEU F 1 15 ? -34.865 16.994  19.494 1.00 27.27 ? 15  LEU F CD2   1 
ATOM   2602 N N     . ARG F 1 16 ? -34.245 21.571  17.025 1.00 38.27 ? 16  ARG F N     1 
ATOM   2603 C CA    . ARG F 1 16 ? -34.141 23.004  16.663 1.00 37.61 ? 16  ARG F CA    1 
ATOM   2604 C C     . ARG F 1 16 ? -35.563 23.494  16.343 1.00 25.72 ? 16  ARG F C     1 
ATOM   2605 O O     . ARG F 1 16 ? -35.951 24.481  16.931 1.00 38.62 ? 16  ARG F O     1 
ATOM   2606 C CB    . ARG F 1 16 ? -33.137 23.191  15.519 1.00 32.54 ? 16  ARG F CB    1 
ATOM   2607 C CG    . ARG F 1 16 ? -32.603 24.605  15.366 1.00 34.71 ? 16  ARG F CG    1 
ATOM   2608 C CD    . ARG F 1 16 ? -31.636 24.701  14.209 1.00 32.75 ? 16  ARG F CD    1 
ATOM   2609 N NE    . ARG F 1 16 ? -32.309 24.424  12.955 1.00 40.17 ? 16  ARG F NE    1 
ATOM   2610 C CZ    . ARG F 1 16 ? -31.721 24.369  11.767 1.00 53.28 ? 16  ARG F CZ    1 
ATOM   2611 N NH1   . ARG F 1 16 ? -30.452 24.711  11.627 1.00 51.12 ? 16  ARG F NH1   1 
ATOM   2612 N NH2   . ARG F 1 16 ? -32.414 23.970  10.716 1.00 45.01 ? 16  ARG F NH2   1 
ATOM   2613 N N     . ARG F 1 17 ? -36.315 22.826  15.456 1.00 41.12 ? 17  ARG F N     1 
ATOM   2614 C CA    A ARG F 1 17 ? -37.591 23.359  14.989 0.46 35.31 ? 17  ARG F CA    1 
ATOM   2615 C CA    B ARG F 1 17 ? -37.592 23.359  14.991 0.54 35.31 ? 17  ARG F CA    1 
ATOM   2616 C C     . ARG F 1 17 ? -38.569 23.556  16.143 1.00 35.11 ? 17  ARG F C     1 
ATOM   2617 O O     . ARG F 1 17 ? -39.297 24.554  16.181 1.00 37.89 ? 17  ARG F O     1 
ATOM   2618 C CB    A ARG F 1 17 ? -38.179 22.435  13.918 0.46 32.91 ? 17  ARG F CB    1 
ATOM   2619 C CB    B ARG F 1 17 ? -38.195 22.427  13.940 0.54 32.84 ? 17  ARG F CB    1 
ATOM   2620 C CG    A ARG F 1 17 ? -39.121 21.350  14.429 0.46 33.88 ? 17  ARG F CG    1 
ATOM   2621 C CG    B ARG F 1 17 ? -39.164 23.110  12.990 0.54 38.31 ? 17  ARG F CG    1 
ATOM   2622 C CD    A ARG F 1 17 ? -39.788 20.606  13.274 0.46 27.94 ? 17  ARG F CD    1 
ATOM   2623 C CD    B ARG F 1 17 ? -38.431 23.786  11.839 0.54 38.76 ? 17  ARG F CD    1 
ATOM   2624 N NE    A ARG F 1 17 ? -39.091 19.370  12.932 0.46 32.94 ? 17  ARG F NE    1 
ATOM   2625 N NE    B ARG F 1 17 ? -39.172 24.928  11.318 0.54 49.81 ? 17  ARG F NE    1 
ATOM   2626 C CZ    A ARG F 1 17 ? -38.235 19.233  11.927 0.46 38.49 ? 17  ARG F CZ    1 
ATOM   2627 C CZ    B ARG F 1 17 ? -39.029 25.425  10.096 0.54 46.28 ? 17  ARG F CZ    1 
ATOM   2628 N NH1   A ARG F 1 17 ? -37.930 20.246  11.132 0.46 47.78 ? 17  ARG F NH1   1 
ATOM   2629 N NH1   B ARG F 1 17 ? -38.191 24.888  9.224  0.54 49.66 ? 17  ARG F NH1   1 
ATOM   2630 N NH2   A ARG F 1 17 ? -37.674 18.047  11.711 0.46 37.24 ? 17  ARG F NH2   1 
ATOM   2631 N NH2   B ARG F 1 17 ? -39.740 26.492  9.743  0.54 40.23 ? 17  ARG F NH2   1 
ATOM   2632 N N     . GLU F 1 18 ? -38.605 22.619  17.088 1.00 31.49 ? 18  GLU F N     1 
ATOM   2633 C CA    . GLU F 1 18 ? -39.548 22.686  18.198 1.00 24.62 ? 18  GLU F CA    1 
ATOM   2634 C C     . GLU F 1 18 ? -39.021 23.481  19.388 1.00 31.64 ? 18  GLU F C     1 
ATOM   2635 O O     . GLU F 1 18 ? -39.760 23.672  20.360 1.00 30.41 ? 18  GLU F O     1 
ATOM   2636 C CB    . GLU F 1 18 ? -39.929 21.273  18.655 1.00 34.48 ? 18  GLU F CB    1 
ATOM   2637 C CG    . GLU F 1 18 ? -40.602 20.426  17.584 1.00 32.90 ? 18  GLU F CG    1 
ATOM   2638 C CD    . GLU F 1 18 ? -41.937 20.992  17.143 1.00 51.79 ? 18  GLU F CD    1 
ATOM   2639 O OE1   . GLU F 1 18 ? -42.952 20.698  17.808 1.00 32.62 ? 18  GLU F OE1   1 
ATOM   2640 O OE2   . GLU F 1 18 ? -41.975 21.726  16.132 1.00 44.34 ? 18  GLU F OE2   1 
ATOM   2641 N N     . ARG F 1 19 ? -37.795 24.015  19.302 1.00 24.18 ? 19  ARG F N     1 
ATOM   2642 C CA    . ARG F 1 19 ? -37.190 24.867  20.361 1.00 19.26 ? 19  ARG F CA    1 
ATOM   2643 C C     . ARG F 1 19 ? -37.354 24.140  21.693 1.00 13.39 ? 19  ARG F C     1 
ATOM   2644 O O     . ARG F 1 19 ? -37.644 24.774  22.686 1.00 16.32 ? 19  ARG F O     1 
ATOM   2645 C CB    . ARG F 1 19 ? -37.796 26.267  20.301 1.00 27.19 ? 19  ARG F CB    1 
ATOM   2646 C CG    . ARG F 1 19 ? -36.842 27.325  19.777 1.00 18.47 ? 19  ARG F CG    1 
ATOM   2647 C CD    . ARG F 1 19 ? -36.681 27.163  18.286 1.00 29.93 ? 19  ARG F CD    1 
ATOM   2648 N NE    . ARG F 1 19 ? -36.699 28.431  17.582 1.00 32.75 ? 19  ARG F NE    1 
ATOM   2649 C CZ    . ARG F 1 19 ? -36.611 28.547  16.266 1.00 33.89 ? 19  ARG F CZ    1 
ATOM   2650 N NH1   . ARG F 1 19 ? -36.802 27.490  15.500 1.00 24.49 ? 19  ARG F NH1   1 
ATOM   2651 N NH2   . ARG F 1 19 ? -36.333 29.717  15.723 1.00 32.62 ? 19  ARG F NH2   1 
ATOM   2652 N N     . VAL F 1 20 ? -37.106 22.843  21.669 1.00 30.39 ? 20  VAL F N     1 
ATOM   2653 C CA    . VAL F 1 20 ? -37.227 21.954  22.851 1.00 21.40 ? 20  VAL F CA    1 
ATOM   2654 C C     . VAL F 1 20 ? -35.887 21.935  23.571 1.00 22.53 ? 20  VAL F C     1 
ATOM   2655 O O     . VAL F 1 20 ? -34.856 21.807  22.915 1.00 16.41 ? 20  VAL F O     1 
ATOM   2656 C CB    . VAL F 1 20 ? -37.633 20.522  22.449 1.00 39.41 ? 20  VAL F CB    1 
ATOM   2657 C CG1   . VAL F 1 20 ? -36.934 20.025  21.198 1.00 32.99 ? 20  VAL F CG1   1 
ATOM   2658 C CG2   . VAL F 1 20 ? -37.422 19.550  23.598 1.00 34.63 ? 20  VAL F CG2   1 
ATOM   2659 N N     . PRO F 1 21 ? -35.884 22.019  24.908 1.00 25.51 ? 21  PRO F N     1 
ATOM   2660 C CA    . PRO F 1 21 ? -34.646 21.973  25.659 1.00 19.68 ? 21  PRO F CA    1 
ATOM   2661 C C     . PRO F 1 21 ? -33.905 20.633  25.527 1.00 23.43 ? 21  PRO F C     1 
ATOM   2662 O O     . PRO F 1 21 ? -34.553 19.642  25.319 1.00 21.76 ? 21  PRO F O     1 
ATOM   2663 C CB    . PRO F 1 21 ? -35.112 22.227  27.094 1.00 30.19 ? 21  PRO F CB    1 
ATOM   2664 C CG    . PRO F 1 21 ? -36.451 22.884  26.961 1.00 27.64 ? 21  PRO F CG    1 
ATOM   2665 C CD    . PRO F 1 21 ? -37.052 22.201  25.761 1.00 37.36 ? 21  PRO F CD    1 
ATOM   2666 N N     . ALA F 1 22 ? -32.578 20.652  25.612 1.00 20.46 ? 22  ALA F N     1 
ATOM   2667 C CA    . ALA F 1 22 ? -31.737 19.448  25.466 1.00 24.48 ? 22  ALA F CA    1 
ATOM   2668 C C     . ALA F 1 22 ? -30.611 19.374  26.483 1.00 16.61 ? 22  ALA F C     1 
ATOM   2669 O O     . ALA F 1 22 ? -30.328 20.366  27.127 1.00 29.23 ? 22  ALA F O     1 
ATOM   2670 C CB    . ALA F 1 22 ? -31.148 19.368  24.081 1.00 30.00 ? 22  ALA F CB    1 
ATOM   2671 N N     . SER F 1 23 ? -29.993 18.213  26.576 1.00 25.05 ? 23  SER F N     1 
ATOM   2672 C CA    . SER F 1 23 ? -28.848 17.955  27.462 1.00 12.65 ? 23  SER F CA    1 
ATOM   2673 C C     . SER F 1 23 ? -27.796 17.242  26.605 1.00 27.25 ? 23  SER F C     1 
ATOM   2674 O O     . SER F 1 23 ? -28.119 16.174  26.066 1.00 22.67 ? 23  SER F O     1 
ATOM   2675 C CB    . SER F 1 23 ? -29.280 17.191  28.670 1.00 7.28  ? 23  SER F CB    1 
ATOM   2676 O OG    . SER F 1 23 ? -30.340 17.830  29.349 1.00 17.18 ? 23  SER F OG    1 
ATOM   2677 N N     . ILE F 1 24 ? -26.639 17.855  26.377 1.00 17.19 ? 24  ILE F N     1 
ATOM   2678 C CA    . ILE F 1 24 ? -25.517 17.210  25.643 1.00 33.57 ? 24  ILE F CA    1 
ATOM   2679 C C     . ILE F 1 24 ? -24.552 16.641  26.677 1.00 11.50 ? 24  ILE F C     1 
ATOM   2680 O O     . ILE F 1 24 ? -23.938 17.420  27.394 1.00 7.33  ? 24  ILE F O     1 
ATOM   2681 C CB    . ILE F 1 24 ? -24.800 18.122  24.628 1.00 13.64 ? 24  ILE F CB    1 
ATOM   2682 C CG1   . ILE F 1 24 ? -25.731 18.470  23.466 1.00 22.58 ? 24  ILE F CG1   1 
ATOM   2683 C CG2   . ILE F 1 24 ? -23.505 17.500  24.144 1.00 2.79  ? 24  ILE F CG2   1 
ATOM   2684 C CD1   . ILE F 1 24 ? -25.258 19.621  22.628 1.00 17.96 ? 24  ILE F CD1   1 
ATOM   2685 N N     . TYR F 1 25 ? -24.510 15.329  26.762 1.00 7.16  ? 25  TYR F N     1 
ATOM   2686 C CA    . TYR F 1 25 ? -23.549 14.636  27.644 1.00 14.28 ? 25  TYR F CA    1 
ATOM   2687 C C     . TYR F 1 25 ? -22.241 14.545  26.854 1.00 8.04  ? 25  TYR F C     1 
ATOM   2688 O O     . TYR F 1 25 ? -22.326 14.192  25.697 1.00 8.47  ? 25  TYR F O     1 
ATOM   2689 C CB    . TYR F 1 25 ? -24.111 13.287  28.089 1.00 14.31 ? 25  TYR F CB    1 
ATOM   2690 C CG    . TYR F 1 25 ? -25.246 13.373  29.070 1.00 10.47 ? 25  TYR F CG    1 
ATOM   2691 C CD1   . TYR F 1 25 ? -24.997 13.433  30.426 1.00 7.37  ? 25  TYR F CD1   1 
ATOM   2692 C CD2   . TYR F 1 25 ? -26.563 13.391  28.649 1.00 14.99 ? 25  TYR F CD2   1 
ATOM   2693 C CE1   . TYR F 1 25 ? -26.027 13.499  31.344 1.00 21.98 ? 25  TYR F CE1   1 
ATOM   2694 C CE2   . TYR F 1 25 ? -27.607 13.470  29.554 1.00 13.71 ? 25  TYR F CE2   1 
ATOM   2695 C CZ    . TYR F 1 25 ? -27.337 13.517  30.908 1.00 12.53 ? 25  TYR F CZ    1 
ATOM   2696 O OH    . TYR F 1 25 ? -28.344 13.594  31.826 1.00 13.23 ? 25  TYR F OH    1 
ATOM   2697 N N     . LEU F 1 26 ? -21.151 15.055  27.377 1.00 6.35  ? 26  LEU F N     1 
ATOM   2698 C CA    . LEU F 1 26 ? -19.844 14.972  26.745 1.00 13.07 ? 26  LEU F CA    1 
ATOM   2699 C C     . LEU F 1 26 ? -19.136 13.684  27.155 1.00 11.28 ? 26  LEU F C     1 
ATOM   2700 O O     . LEU F 1 26 ? -19.505 13.024  28.129 1.00 9.19  ? 26  LEU F O     1 
ATOM   2701 C CB    . LEU F 1 26 ? -18.989 16.185  27.111 1.00 20.87 ? 26  LEU F CB    1 
ATOM   2702 C CG    . LEU F 1 26 ? -19.622 17.543  26.797 1.00 10.79 ? 26  LEU F CG    1 
ATOM   2703 C CD1   . LEU F 1 26 ? -18.811 18.679  27.402 1.00 8.18  ? 26  LEU F CD1   1 
ATOM   2704 C CD2   . LEU F 1 26 ? -19.773 17.720  25.292 1.00 18.16 ? 26  LEU F CD2   1 
ATOM   2705 N N     . VAL F 1 27 ? -18.097 13.336  26.392 1.00 17.88 ? 27  VAL F N     1 
ATOM   2706 C CA    . VAL F 1 27 ? -17.407 12.069  26.599 1.00 10.49 ? 27  VAL F CA    1 
ATOM   2707 C C     . VAL F 1 27 ? -16.849 11.943  28.008 1.00 5.34  ? 27  VAL F C     1 
ATOM   2708 O O     . VAL F 1 27 ? -16.571 10.829  28.463 1.00 7.57  ? 27  VAL F O     1 
ATOM   2709 C CB    . VAL F 1 27 ? -16.282 11.898  25.557 1.00 6.96  ? 27  VAL F CB    1 
ATOM   2710 C CG1   . VAL F 1 27 ? -16.871 11.594  24.191 1.00 6.25  ? 27  VAL F CG1   1 
ATOM   2711 C CG2   . VAL F 1 27 ? -15.406 13.144  25.502 1.00 21.51 ? 27  VAL F CG2   1 
ATOM   2712 N N     . ASN F 1 28 ? -16.675 13.057  28.715 1.00 10.84 ? 28  ASN F N     1 
ATOM   2713 C CA    . ASN F 1 28 ? -16.174 13.045  30.081 1.00 8.71  ? 28  ASN F CA    1 
ATOM   2714 C C     . ASN F 1 28 ? -17.292 13.094  31.115 1.00 8.18  ? 28  ASN F C     1 
ATOM   2715 O O     . ASN F 1 28 ? -17.013 13.248  32.309 1.00 8.29  ? 28  ASN F O     1 
ATOM   2716 C CB    . ASN F 1 28 ? -15.210 14.213  30.295 1.00 29.24 ? 28  ASN F CB    1 
ATOM   2717 C CG    . ASN F 1 28 ? -15.912 15.551  30.301 1.00 18.27 ? 28  ASN F CG    1 
ATOM   2718 O OD1   . ASN F 1 28 ? -16.145 16.137  31.356 1.00 42.57 ? 28  ASN F OD1   1 
ATOM   2719 N ND2   . ASN F 1 28 ? -16.255 16.045  29.117 1.00 21.70 ? 28  ASN F ND2   1 
ATOM   2720 N N     . GLY F 1 29 ? -18.548 12.964  30.686 1.00 24.36 ? 29  GLY F N     1 
ATOM   2721 C CA    . GLY F 1 29 ? -19.679 12.955  31.582 1.00 13.72 ? 29  GLY F CA    1 
ATOM   2722 C C     . GLY F 1 29 ? -20.353 14.296  31.775 1.00 15.56 ? 29  GLY F C     1 
ATOM   2723 O O     . GLY F 1 29 ? -21.531 14.333  32.150 1.00 5.88  ? 29  GLY F O     1 
ATOM   2724 N N     . ILE F 1 30 ? -19.639 15.396  31.529 1.00 16.67 ? 30  ILE F N     1 
ATOM   2725 C CA    . ILE F 1 30 ? -20.215 16.723  31.703 1.00 23.19 ? 30  ILE F CA    1 
ATOM   2726 C C     . ILE F 1 30 ? -21.500 16.826  30.898 1.00 5.01  ? 30  ILE F C     1 
ATOM   2727 O O     . ILE F 1 30 ? -21.532 16.496  29.708 1.00 16.49 ? 30  ILE F O     1 
ATOM   2728 C CB    . ILE F 1 30 ? -19.199 17.801  31.281 1.00 17.30 ? 30  ILE F CB    1 
ATOM   2729 C CG1   . ILE F 1 30 ? -18.312 18.216  32.460 1.00 18.73 ? 30  ILE F CG1   1 
ATOM   2730 C CG2   . ILE F 1 30 ? -19.917 19.012  30.690 1.00 16.56 ? 30  ILE F CG2   1 
ATOM   2731 C CD1   . ILE F 1 30 ? -18.027 17.106  33.461 1.00 18.86 ? 30  ILE F CD1   1 
ATOM   2732 N N     . LYS F 1 31 ? -22.538 17.281  31.589 1.00 5.99  ? 31  LYS F N     1 
ATOM   2733 C CA    A LYS F 1 31 ? -23.847 17.490  30.920 0.82 17.59 ? 31  LYS F CA    1 
ATOM   2734 C CA    B LYS F 1 31 ? -23.841 17.486  30.902 0.18 17.68 ? 31  LYS F CA    1 
ATOM   2735 C C     . LYS F 1 31 ? -24.120 18.975  30.644 1.00 15.24 ? 31  LYS F C     1 
ATOM   2736 O O     . LYS F 1 31 ? -24.229 19.848  31.567 1.00 17.07 ? 31  LYS F O     1 
ATOM   2737 C CB    A LYS F 1 31 ? -25.009 16.970  31.758 0.82 21.22 ? 31  LYS F CB    1 
ATOM   2738 C CB    B LYS F 1 31 ? -25.000 16.894  31.702 0.18 21.26 ? 31  LYS F CB    1 
ATOM   2739 C CG    A LYS F 1 31 ? -26.372 17.066  31.093 0.82 20.38 ? 31  LYS F CG    1 
ATOM   2740 C CG    B LYS F 1 31 ? -26.268 16.705  30.884 0.18 20.70 ? 31  LYS F CG    1 
ATOM   2741 C CD    A LYS F 1 31 ? -27.393 17.713  31.975 0.82 29.05 ? 31  LYS F CD    1 
ATOM   2742 C CD    B LYS F 1 31 ? -27.490 16.502  31.729 0.18 24.79 ? 31  LYS F CD    1 
ATOM   2743 C CE    A LYS F 1 31 ? -27.738 16.850  33.168 0.82 30.98 ? 31  LYS F CE    1 
ATOM   2744 C CE    B LYS F 1 31 ? -27.952 17.792  32.361 0.18 29.57 ? 31  LYS F CE    1 
ATOM   2745 N NZ    A LYS F 1 31 ? -29.082 16.250  33.020 0.82 33.98 ? 31  LYS F NZ    1 
ATOM   2746 N NZ    B LYS F 1 31 ? -27.763 17.766  33.827 0.18 29.44 ? 31  LYS F NZ    1 
ATOM   2747 N N     . LEU F 1 32 ? -24.156 19.311  29.375 1.00 21.45 ? 32  LEU F N     1 
ATOM   2748 C CA    . LEU F 1 32 ? -24.428 20.692  28.950 1.00 15.49 ? 32  LEU F CA    1 
ATOM   2749 C C     . LEU F 1 32 ? -25.901 20.792  28.538 1.00 27.16 ? 32  LEU F C     1 
ATOM   2750 O O     . LEU F 1 32 ? -26.289 20.112  27.594 1.00 14.23 ? 32  LEU F O     1 
ATOM   2751 C CB    . LEU F 1 32 ? -23.497 20.992  27.778 1.00 22.56 ? 32  LEU F CB    1 
ATOM   2752 C CG    . LEU F 1 32 ? -22.007 21.090  28.099 1.00 16.73 ? 32  LEU F CG    1 
ATOM   2753 C CD1   . LEU F 1 32 ? -21.270 21.743  26.943 1.00 9.89  ? 32  LEU F CD1   1 
ATOM   2754 C CD2   . LEU F 1 32 ? -21.756 21.846  29.394 1.00 5.19  ? 32  LEU F CD2   1 
ATOM   2755 N N     . GLN F 1 33 ? -26.678 21.614  29.231 1.00 26.65 ? 33  GLN F N     1 
ATOM   2756 C CA    . GLN F 1 33 ? -28.106 21.836  28.896 1.00 29.45 ? 33  GLN F CA    1 
ATOM   2757 C C     . GLN F 1 33 ? -28.288 23.155  28.151 1.00 29.63 ? 33  GLN F C     1 
ATOM   2758 O O     . GLN F 1 33 ? -27.765 24.159  28.594 1.00 22.26 ? 33  GLN F O     1 
ATOM   2759 C CB    . GLN F 1 33 ? -28.968 21.819  30.145 1.00 21.99 ? 33  GLN F CB    1 
ATOM   2760 C CG    . GLN F 1 33 ? -28.867 20.525  30.923 1.00 26.45 ? 33  GLN F CG    1 
ATOM   2761 C CD    . GLN F 1 33 ? -29.484 20.680  32.286 1.00 16.36 ? 33  GLN F CD    1 
ATOM   2762 O OE1   . GLN F 1 33 ? -28.824 20.533  33.308 1.00 35.53 ? 33  GLN F OE1   1 
ATOM   2763 N NE2   . GLN F 1 33 ? -30.764 20.997  32.306 1.00 18.05 ? 33  GLN F NE2   1 
ATOM   2764 N N     . GLY F 1 34 ? -29.036 23.120  27.064 1.00 27.53 ? 34  GLY F N     1 
ATOM   2765 C CA    . GLY F 1 34 ? -29.333 24.325  26.294 1.00 23.58 ? 34  GLY F CA    1 
ATOM   2766 C C     . GLY F 1 34 ? -30.257 24.040  25.146 1.00 19.45 ? 34  GLY F C     1 
ATOM   2767 O O     . GLY F 1 34 ? -30.925 23.014  25.190 1.00 23.62 ? 34  GLY F O     1 
ATOM   2768 N N     . GLN F 1 35 ? -30.241 24.902  24.142 1.00 10.67 ? 35  GLN F N     1 
ATOM   2769 C CA    . GLN F 1 35 ? -31.106 24.764  22.963 1.00 21.99 ? 35  GLN F CA    1 
ATOM   2770 C C     . GLN F 1 35 ? -30.255 24.587  21.714 1.00 13.20 ? 35  GLN F C     1 
ATOM   2771 O O     . GLN F 1 35 ? -29.348 25.374  21.513 1.00 14.67 ? 35  GLN F O     1 
ATOM   2772 C CB    . GLN F 1 35 ? -31.996 26.006  22.809 1.00 34.89 ? 35  GLN F CB    1 
ATOM   2773 C CG    . GLN F 1 35 ? -33.174 26.045  23.764 1.00 36.34 ? 35  GLN F CG    1 
ATOM   2774 C CD    . GLN F 1 35 ? -34.394 25.360  23.203 1.00 26.87 ? 35  GLN F CD    1 
ATOM   2775 O OE1   . GLN F 1 35 ? -34.614 25.334  21.997 1.00 31.41 ? 35  GLN F OE1   1 
ATOM   2776 N NE2   . GLN F 1 35 ? -35.194 24.795  24.091 1.00 36.27 ? 35  GLN F NE2   1 
ATOM   2777 N N     . ILE F 1 36 ? -30.572 23.580  20.921 1.00 16.41 ? 36  ILE F N     1 
ATOM   2778 C CA    . ILE F 1 36 ? -29.893 23.365  19.624 1.00 27.96 ? 36  ILE F CA    1 
ATOM   2779 C C     . ILE F 1 36 ? -30.311 24.530  18.732 1.00 15.71 ? 36  ILE F C     1 
ATOM   2780 O O     . ILE F 1 36 ? -31.486 24.637  18.484 1.00 32.48 ? 36  ILE F O     1 
ATOM   2781 C CB    . ILE F 1 36 ? -30.239 21.992  19.019 1.00 27.66 ? 36  ILE F CB    1 
ATOM   2782 C CG1   . ILE F 1 36 ? -29.919 20.837  19.971 1.00 17.94 ? 36  ILE F CG1   1 
ATOM   2783 C CG2   . ILE F 1 36 ? -29.536 21.830  17.682 1.00 37.88 ? 36  ILE F CG2   1 
ATOM   2784 C CD1   . ILE F 1 36 ? -28.453 20.532  20.075 1.00 27.15 ? 36  ILE F CD1   1 
ATOM   2785 N N     . GLU F 1 37 ? -29.385 25.396  18.356 1.00 36.71 ? 37  GLU F N     1 
ATOM   2786 C CA    . GLU F 1 37 ? -29.645 26.591  17.504 1.00 13.65 ? 37  GLU F CA    1 
ATOM   2787 C C     . GLU F 1 37 ? -29.135 26.386  16.069 1.00 21.28 ? 37  GLU F C     1 
ATOM   2788 O O     . GLU F 1 37 ? -29.612 27.117  15.211 1.00 21.70 ? 37  GLU F O     1 
ATOM   2789 C CB    . GLU F 1 37 ? -28.987 27.771  18.204 1.00 18.76 ? 37  GLU F CB    1 
ATOM   2790 C CG    . GLU F 1 37 ? -27.659 28.236  17.651 1.00 34.84 ? 37  GLU F CG    1 
ATOM   2791 C CD    . GLU F 1 37 ? -27.350 29.669  18.041 1.00 39.29 ? 37  GLU F CD    1 
ATOM   2792 O OE1   . GLU F 1 37 ? -27.448 29.989  19.240 1.00 42.79 ? 37  GLU F OE1   1 
ATOM   2793 O OE2   . GLU F 1 37 ? -27.054 30.469  17.137 1.00 36.31 ? 37  GLU F OE2   1 
ATOM   2794 N N     . SER F 1 38 ? -28.172 25.483  15.826 1.00 24.35 ? 38  SER F N     1 
ATOM   2795 C CA    . SER F 1 38 ? -27.592 25.265  14.508 1.00 20.53 ? 38  SER F CA    1 
ATOM   2796 C C     . SER F 1 38 ? -26.528 24.186  14.656 1.00 10.90 ? 38  SER F C     1 
ATOM   2797 O O     . SER F 1 38 ? -26.120 23.838  15.768 1.00 13.62 ? 38  SER F O     1 
ATOM   2798 C CB    . SER F 1 38 ? -26.996 26.544  13.920 1.00 21.73 ? 38  SER F CB    1 
ATOM   2799 O OG    . SER F 1 38 ? -26.282 27.270  14.901 1.00 37.81 ? 38  SER F OG    1 
ATOM   2800 N N     . PHE F 1 39 ? -26.084 23.659  13.521 1.00 24.38 ? 39  PHE F N     1 
ATOM   2801 C CA    . PHE F 1 39 ? -25.114 22.575  13.518 1.00 18.41 ? 39  PHE F CA    1 
ATOM   2802 C C     . PHE F 1 39 ? -24.630 22.365  12.093 1.00 32.97 ? 39  PHE F C     1 
ATOM   2803 O O     . PHE F 1 39 ? -25.318 22.712  11.129 1.00 16.56 ? 39  PHE F O     1 
ATOM   2804 C CB    . PHE F 1 39 ? -25.717 21.280  14.069 1.00 24.53 ? 39  PHE F CB    1 
ATOM   2805 C CG    . PHE F 1 39 ? -26.935 20.817  13.323 1.00 27.36 ? 39  PHE F CG    1 
ATOM   2806 C CD1   . PHE F 1 39 ? -28.190 21.301  13.650 1.00 28.80 ? 39  PHE F CD1   1 
ATOM   2807 C CD2   . PHE F 1 39 ? -26.824 19.902  12.289 1.00 28.88 ? 39  PHE F CD2   1 
ATOM   2808 C CE1   . PHE F 1 39 ? -29.313 20.878  12.964 1.00 36.13 ? 39  PHE F CE1   1 
ATOM   2809 C CE2   . PHE F 1 39 ? -27.942 19.475  11.599 1.00 42.28 ? 39  PHE F CE2   1 
ATOM   2810 C CZ    . PHE F 1 39 ? -29.188 19.964  11.937 1.00 45.35 ? 39  PHE F CZ    1 
ATOM   2811 N N     . ASP F 1 40 ? -23.439 21.793  11.978 1.00 18.12 ? 40  ASP F N     1 
ATOM   2812 C CA    . ASP F 1 40 ? -22.878 21.430  10.683 1.00 30.06 ? 40  ASP F CA    1 
ATOM   2813 C C     . ASP F 1 40 ? -22.297 20.025  10.810 1.00 34.36 ? 40  ASP F C     1 
ATOM   2814 O O     . ASP F 1 40 ? -22.649 19.259  11.713 1.00 31.71 ? 40  ASP F O     1 
ATOM   2815 C CB    . ASP F 1 40 ? -21.856 22.483  10.222 1.00 22.21 ? 40  ASP F CB    1 
ATOM   2816 C CG    . ASP F 1 40 ? -20.602 22.506  11.078 1.00 27.65 ? 40  ASP F CG    1 
ATOM   2817 O OD1   . ASP F 1 40 ? -20.488 21.684  12.011 1.00 30.42 ? 40  ASP F OD1   1 
ATOM   2818 O OD2   . ASP F 1 40 ? -19.724 23.354  10.814 1.00 32.00 ? 40  ASP F OD2   1 
ATOM   2819 N N     . GLN F 1 41 ? -21.388 19.677  9.899  1.00 34.53 ? 41  GLN F N     1 
ATOM   2820 C CA    . GLN F 1 41 ? -20.812 18.339  9.894  1.00 33.76 ? 41  GLN F CA    1 
ATOM   2821 C C     . GLN F 1 41 ? -19.963 18.062  11.125 1.00 33.48 ? 41  GLN F C     1 
ATOM   2822 O O     . GLN F 1 41 ? -19.784 16.894  11.486 1.00 21.70 ? 41  GLN F O     1 
ATOM   2823 C CB    . GLN F 1 41 ? -19.960 18.145  8.639  1.00 29.32 ? 41  GLN F CB    1 
ATOM   2824 C CG    . GLN F 1 41 ? -19.175 16.844  8.590  1.00 36.42 ? 41  GLN F CG    1 
ATOM   2825 C CD    . GLN F 1 41 ? -18.499 16.632  7.247  1.00 50.82 ? 41  GLN F CD    1 
ATOM   2826 O OE1   . GLN F 1 41 ? -18.606 17.468  6.350  1.00 55.13 ? 41  GLN F OE1   1 
ATOM   2827 N NE2   . GLN F 1 41 ? -17.799 15.512  7.104  1.00 24.55 ? 41  GLN F NE2   1 
ATOM   2828 N N     . PHE F 1 42 ? -19.441 19.100  11.780 1.00 22.95 ? 42  PHE F N     1 
ATOM   2829 C CA    . PHE F 1 42 ? -18.464 18.909  12.839 1.00 17.69 ? 42  PHE F CA    1 
ATOM   2830 C C     . PHE F 1 42 ? -18.836 19.532  14.175 1.00 9.19  ? 42  PHE F C     1 
ATOM   2831 O O     . PHE F 1 42 ? -18.234 19.159  15.187 1.00 10.99 ? 42  PHE F O     1 
ATOM   2832 C CB    . PHE F 1 42 ? -17.101 19.479  12.412 1.00 23.20 ? 42  PHE F CB    1 
ATOM   2833 C CG    . PHE F 1 42 ? -16.571 18.893  11.136 1.00 22.99 ? 42  PHE F CG    1 
ATOM   2834 C CD1   . PHE F 1 42 ? -15.932 17.665  11.134 1.00 13.31 ? 42  PHE F CD1   1 
ATOM   2835 C CD2   . PHE F 1 42 ? -16.711 19.572  9.938  1.00 21.61 ? 42  PHE F CD2   1 
ATOM   2836 C CE1   . PHE F 1 42 ? -15.441 17.126  9.961  1.00 29.85 ? 42  PHE F CE1   1 
ATOM   2837 C CE2   . PHE F 1 42 ? -16.224 19.038  8.762  1.00 28.54 ? 42  PHE F CE2   1 
ATOM   2838 C CZ    . PHE F 1 42 ? -15.588 17.813  8.774  1.00 28.31 ? 42  PHE F CZ    1 
ATOM   2839 N N     . VAL F 1 43 ? -19.793 20.457  14.222 1.00 16.88 ? 43  VAL F N     1 
ATOM   2840 C CA    . VAL F 1 43 ? -20.078 21.178  15.454 1.00 16.65 ? 43  VAL F CA    1 
ATOM   2841 C C     . VAL F 1 43 ? -21.573 21.410  15.608 1.00 24.73 ? 43  VAL F C     1 
ATOM   2842 O O     . VAL F 1 43 ? -22.317 21.511  14.628 1.00 14.54 ? 43  VAL F O     1 
ATOM   2843 C CB    . VAL F 1 43 ? -19.332 22.531  15.510 1.00 21.35 ? 43  VAL F CB    1 
ATOM   2844 C CG1   . VAL F 1 43 ? -17.831 22.312  15.595 1.00 18.50 ? 43  VAL F CG1   1 
ATOM   2845 C CG2   . VAL F 1 43 ? -19.687 23.384  14.301 1.00 25.86 ? 43  VAL F CG2   1 
ATOM   2846 N N     . ILE F 1 44 ? -22.001 21.496  16.864 1.00 17.11 ? 44  ILE F N     1 
ATOM   2847 C CA    . ILE F 1 44 ? -23.334 21.941  17.237 1.00 18.92 ? 44  ILE F CA    1 
ATOM   2848 C C     . ILE F 1 44 ? -23.183 23.232  18.030 1.00 9.38  ? 44  ILE F C     1 
ATOM   2849 O O     . ILE F 1 44 ? -22.215 23.412  18.776 1.00 6.95  ? 44  ILE F O     1 
ATOM   2850 C CB    . ILE F 1 44 ? -24.090 20.881  18.066 1.00 7.29  ? 44  ILE F CB    1 
ATOM   2851 C CG1   . ILE F 1 44 ? -24.395 19.651  17.209 1.00 20.92 ? 44  ILE F CG1   1 
ATOM   2852 C CG2   . ILE F 1 44 ? -25.375 21.467  18.635 1.00 4.18  ? 44  ILE F CG2   1 
ATOM   2853 C CD1   . ILE F 1 44 ? -24.843 18.447  18.016 1.00 29.65 ? 44  ILE F CD1   1 
ATOM   2854 N N     . LEU F 1 45 ? -24.153 24.129  17.874 1.00 29.45 ? 45  LEU F N     1 
ATOM   2855 C CA    . LEU F 1 45 ? -24.166 25.408  18.577 1.00 8.93  ? 45  LEU F CA    1 
ATOM   2856 C C     . LEU F 1 45 ? -25.261 25.367  19.638 1.00 15.06 ? 45  LEU F C     1 
ATOM   2857 O O     . LEU F 1 45 ? -26.450 25.456  19.315 1.00 26.84 ? 45  LEU F O     1 
ATOM   2858 C CB    . LEU F 1 45 ? -24.381 26.563  17.601 1.00 17.84 ? 45  LEU F CB    1 
ATOM   2859 C CG    . LEU F 1 45 ? -23.112 27.109  16.940 1.00 35.76 ? 45  LEU F CG    1 
ATOM   2860 C CD1   . LEU F 1 45 ? -23.426 27.779  15.608 1.00 28.43 ? 45  LEU F CD1   1 
ATOM   2861 C CD2   . LEU F 1 45 ? -22.398 28.074  17.875 1.00 16.79 ? 45  LEU F CD2   1 
ATOM   2862 N N     . LEU F 1 46 ? -24.856 25.227  20.899 1.00 14.16 ? 46  LEU F N     1 
ATOM   2863 C CA    . LEU F 1 46 ? -25.785 25.219  22.021 1.00 22.21 ? 46  LEU F CA    1 
ATOM   2864 C C     . LEU F 1 46 ? -25.998 26.642  22.519 1.00 23.53 ? 46  LEU F C     1 
ATOM   2865 O O     . LEU F 1 46 ? -25.074 27.460  22.503 1.00 13.65 ? 46  LEU F O     1 
ATOM   2866 C CB    . LEU F 1 46 ? -25.253 24.339  23.153 1.00 9.15  ? 46  LEU F CB    1 
ATOM   2867 C CG    . LEU F 1 46 ? -26.215 24.064  24.308 1.00 24.57 ? 46  LEU F CG    1 
ATOM   2868 C CD1   . LEU F 1 46 ? -27.358 23.182  23.836 1.00 21.69 ? 46  LEU F CD1   1 
ATOM   2869 C CD2   . LEU F 1 46 ? -25.482 23.423  25.475 1.00 15.15 ? 46  LEU F CD2   1 
ATOM   2870 N N     . LYS F 1 47 ? -27.219 26.930  22.967 1.00 28.08 ? 47  LYS F N     1 
ATOM   2871 C CA    . LYS F 1 47 ? -27.631 28.289  23.292 1.00 39.52 ? 47  LYS F CA    1 
ATOM   2872 C C     . LYS F 1 47 ? -28.194 28.363  24.703 1.00 29.03 ? 47  LYS F C     1 
ATOM   2873 O O     . LYS F 1 47 ? -29.073 27.579  25.074 1.00 31.28 ? 47  LYS F O     1 
ATOM   2874 C CB    . LYS F 1 47 ? -28.681 28.796  22.294 1.00 19.89 ? 47  LYS F CB    1 
ATOM   2875 C CG    . LYS F 1 47 ? -28.886 30.307  22.300 1.00 42.69 ? 47  LYS F CG    1 
ATOM   2876 C CD    . LYS F 1 47 ? -30.119 30.711  21.491 1.00 50.42 ? 47  LYS F CD    1 
ATOM   2877 C CE    . LYS F 1 47 ? -31.407 30.197  22.129 1.00 42.11 ? 47  LYS F CE    1 
ATOM   2878 N NZ    . LYS F 1 47 ? -32.594 31.031  21.784 1.00 36.42 ? 47  LYS F NZ    1 
ATOM   2879 N N     . ASN F 1 48 ? -27.680 29.314  25.478 1.00 24.16 ? 48  ASN F N     1 
ATOM   2880 C CA    . ASN F 1 48 ? -28.291 29.759  26.725 1.00 49.22 ? 48  ASN F CA    1 
ATOM   2881 C C     . ASN F 1 48 ? -28.310 31.284  26.683 1.00 47.90 ? 48  ASN F C     1 
ATOM   2882 O O     . ASN F 1 48 ? -28.913 31.863  25.773 1.00 44.17 ? 48  ASN F O     1 
ATOM   2883 C CB    . ASN F 1 48 ? -27.526 29.185  27.911 1.00 53.23 ? 48  ASN F CB    1 
ATOM   2884 C CG    . ASN F 1 48 ? -28.443 28.692  29.013 1.00 54.76 ? 48  ASN F CG    1 
ATOM   2885 O OD1   . ASN F 1 48 ? -29.316 29.418  29.490 1.00 49.84 ? 48  ASN F OD1   1 
ATOM   2886 N ND2   . ASN F 1 48 ? -28.284 27.428  29.383 1.00 26.83 ? 48  ASN F ND2   1 
ATOM   2887 N N     . THR F 1 49 ? -27.459 31.977  27.437 1.00 59.66 ? 49  THR F N     1 
ATOM   2888 C CA    . THR F 1 49 ? -27.296 33.441  27.346 1.00 61.94 ? 49  THR F CA    1 
ATOM   2889 C C     . THR F 1 49 ? -26.306 33.672  26.244 1.00 43.54 ? 49  THR F C     1 
ATOM   2890 O O     . THR F 1 49 ? -26.536 34.570  25.427 1.00 37.11 ? 49  THR F O     1 
ATOM   2891 C CB    . THR F 1 49 ? -26.813 34.001  28.684 1.00 60.42 ? 49  THR F CB    1 
ATOM   2892 O OG1   . THR F 1 49 ? -27.497 35.247  28.737 1.00 72.15 ? 49  THR F OG1   1 
ATOM   2893 C CG2   . THR F 1 49 ? -25.310 34.182  28.801 1.00 45.56 ? 49  THR F CG2   1 
ATOM   2894 N N     . VAL F 1 50 ? -25.236 32.882  26.244 1.00 40.57 ? 50  VAL F N     1 
ATOM   2895 C CA    . VAL F 1 50 ? -24.196 32.969  25.192 1.00 30.24 ? 50  VAL F CA    1 
ATOM   2896 C C     . VAL F 1 50 ? -24.294 31.664  24.407 1.00 18.75 ? 50  VAL F C     1 
ATOM   2897 O O     . VAL F 1 50 ? -24.446 30.602  25.028 1.00 20.39 ? 50  VAL F O     1 
ATOM   2898 C CB    . VAL F 1 50 ? -22.745 33.217  25.650 1.00 46.43 ? 50  VAL F CB    1 
ATOM   2899 C CG1   . VAL F 1 50 ? -22.605 34.481  26.485 1.00 33.37 ? 50  VAL F CG1   1 
ATOM   2900 C CG2   . VAL F 1 50 ? -22.134 32.014  26.359 1.00 31.68 ? 50  VAL F CG2   1 
ATOM   2901 N N     . SER F 1 51 ? -24.290 31.786  23.095 1.00 16.52 ? 51  SER F N     1 
ATOM   2902 C CA    . SER F 1 51 ? -24.266 30.596  22.240 1.00 26.35 ? 51  SER F CA    1 
ATOM   2903 C C     . SER F 1 51 ? -22.818 30.087  22.225 1.00 32.09 ? 51  SER F C     1 
ATOM   2904 O O     . SER F 1 51 ? -21.920 30.903  21.930 1.00 16.98 ? 51  SER F O     1 
ATOM   2905 C CB    . SER F 1 51 ? -24.778 30.909  20.874 1.00 27.71 ? 51  SER F CB    1 
ATOM   2906 O OG    . SER F 1 51 ? -24.382 29.923  19.936 1.00 47.55 ? 51  SER F OG    1 
ATOM   2907 N N     . GLN F 1 52 ? -22.599 28.833  22.592 1.00 17.10 ? 52  GLN F N     1 
ATOM   2908 C CA    . GLN F 1 52 ? -21.286 28.211  22.537 1.00 16.70 ? 52  GLN F CA    1 
ATOM   2909 C C     . GLN F 1 52 ? -21.246 27.175  21.422 1.00 15.36 ? 52  GLN F C     1 
ATOM   2910 O O     . GLN F 1 52 ? -22.277 26.653  20.989 1.00 17.51 ? 52  GLN F O     1 
ATOM   2911 C CB    . GLN F 1 52 ? -20.930 27.550  23.873 1.00 6.69  ? 52  GLN F CB    1 
ATOM   2912 C CG    . GLN F 1 52 ? -21.829 26.384  24.246 1.00 20.65 ? 52  GLN F CG    1 
ATOM   2913 C CD    . GLN F 1 52 ? -21.375 25.683  25.509 1.00 11.66 ? 52  GLN F CD    1 
ATOM   2914 O OE1   . GLN F 1 52 ? -20.375 24.964  25.508 1.00 3.36  ? 52  GLN F OE1   1 
ATOM   2915 N NE2   . GLN F 1 52 ? -22.106 25.892  26.598 1.00 19.45 ? 52  GLN F NE2   1 
ATOM   2916 N N     . MET F 1 53 ? -20.033 26.875  20.968 1.00 18.73 ? 53  MET F N     1 
ATOM   2917 C CA    . MET F 1 53 ? -19.801 25.911  19.901 1.00 22.81 ? 53  MET F CA    1 
ATOM   2918 C C     . MET F 1 53 ? -19.261 24.626  20.511 1.00 16.41 ? 53  MET F C     1 
ATOM   2919 O O     . MET F 1 53 ? -18.218 24.641  21.174 1.00 15.55 ? 53  MET F O     1 
ATOM   2920 C CB    . MET F 1 53 ? -18.826 26.471  18.867 1.00 23.66 ? 53  MET F CB    1 
ATOM   2921 C CG    . MET F 1 53 ? -18.036 25.418  18.116 1.00 9.65  ? 53  MET F CG    1 
ATOM   2922 S SD    . MET F 1 53 ? -17.249 26.103  16.646 1.00 22.13 ? 53  MET F SD    1 
ATOM   2923 C CE    . MET F 1 53 ? -15.572 26.331  17.233 1.00 12.51 ? 53  MET F CE    1 
ATOM   2924 N N     . VAL F 1 54 ? -19.965 23.521  20.281 1.00 23.89 ? 54  VAL F N     1 
ATOM   2925 C CA    . VAL F 1 54 ? -19.609 22.220  20.834 1.00 6.94  ? 54  VAL F CA    1 
ATOM   2926 C C     . VAL F 1 54 ? -19.169 21.315  19.694 1.00 12.04 ? 54  VAL F C     1 
ATOM   2927 O O     . VAL F 1 54 ? -19.878 21.181  18.689 1.00 7.92  ? 54  VAL F O     1 
ATOM   2928 C CB    . VAL F 1 54 ? -20.784 21.595  21.606 1.00 17.45 ? 54  VAL F CB    1 
ATOM   2929 C CG1   . VAL F 1 54 ? -20.366 20.264  22.220 1.00 13.38 ? 54  VAL F CG1   1 
ATOM   2930 C CG2   . VAL F 1 54 ? -21.288 22.553  22.675 1.00 16.19 ? 54  VAL F CG2   1 
ATOM   2931 N N     . TYR F 1 55 ? -18.003 20.695  19.851 1.00 8.58  ? 55  TYR F N     1 
ATOM   2932 C CA    . TYR F 1 55 ? -17.489 19.781  18.842 1.00 11.40 ? 55  TYR F CA    1 
ATOM   2933 C C     . TYR F 1 55 ? -18.160 18.421  18.985 1.00 5.78  ? 55  TYR F C     1 
ATOM   2934 O O     . TYR F 1 55 ? -18.223 17.860  20.083 1.00 1.43  ? 55  TYR F O     1 
ATOM   2935 C CB    . TYR F 1 55 ? -15.974 19.644  18.971 1.00 8.75  ? 55  TYR F CB    1 
ATOM   2936 C CG    . TYR F 1 55 ? -15.213 20.756  18.292 1.00 12.33 ? 55  TYR F CG    1 
ATOM   2937 C CD1   . TYR F 1 55 ? -15.037 20.762  16.915 1.00 7.20  ? 55  TYR F CD1   1 
ATOM   2938 C CD2   . TYR F 1 55 ? -14.677 21.805  19.026 1.00 11.41 ? 55  TYR F CD2   1 
ATOM   2939 C CE1   . TYR F 1 55 ? -14.345 21.779  16.288 1.00 18.23 ? 55  TYR F CE1   1 
ATOM   2940 C CE2   . TYR F 1 55 ? -13.983 22.827  18.408 1.00 27.10 ? 55  TYR F CE2   1 
ATOM   2941 C CZ    . TYR F 1 55 ? -13.820 22.809  17.039 1.00 26.42 ? 55  TYR F CZ    1 
ATOM   2942 O OH    . TYR F 1 55 ? -13.129 23.824  16.418 1.00 17.25 ? 55  TYR F OH    1 
ATOM   2943 N N     . LYS F 1 56 ? -18.660 17.893  17.867 1.00 5.66  ? 56  LYS F N     1 
ATOM   2944 C CA    . LYS F 1 56 ? -19.338 16.602  17.902 1.00 9.79  ? 56  LYS F CA    1 
ATOM   2945 C C     . LYS F 1 56 ? -18.421 15.508  18.438 1.00 12.36 ? 56  LYS F C     1 
ATOM   2946 O O     . LYS F 1 56 ? -18.865 14.635  19.193 1.00 11.03 ? 56  LYS F O     1 
ATOM   2947 C CB    . LYS F 1 56 ? -19.844 16.237  16.507 1.00 16.52 ? 56  LYS F CB    1 
ATOM   2948 C CG    . LYS F 1 56 ? -21.149 16.911  16.104 1.00 11.74 ? 56  LYS F CG    1 
ATOM   2949 C CD    . LYS F 1 56 ? -21.559 16.477  14.703 1.00 21.44 ? 56  LYS F CD    1 
ATOM   2950 C CE    . LYS F 1 56 ? -22.752 17.264  14.188 1.00 24.22 ? 56  LYS F CE    1 
ATOM   2951 N NZ    . LYS F 1 56 ? -23.086 16.901  12.780 1.00 24.48 ? 56  LYS F NZ    1 
ATOM   2952 N N     . HIS F 1 57 ? -17.136 15.540  18.066 1.00 8.79  ? 57  HIS F N     1 
ATOM   2953 C CA    . HIS F 1 57 ? -16.224 14.480  18.487 1.00 6.09  ? 57  HIS F CA    1 
ATOM   2954 C C     . HIS F 1 57 ? -16.120 14.381  20.004 1.00 13.17 ? 57  HIS F C     1 
ATOM   2955 O O     . HIS F 1 57 ? -15.691 13.342  20.518 1.00 10.56 ? 57  HIS F O     1 
ATOM   2956 C CB    . HIS F 1 57 ? -14.833 14.688  17.871 1.00 10.16 ? 57  HIS F CB    1 
ATOM   2957 C CG    . HIS F 1 57 ? -14.167 15.970  18.271 1.00 6.69  ? 57  HIS F CG    1 
ATOM   2958 N ND1   . HIS F 1 57 ? -13.774 16.918  17.351 1.00 4.87  ? 57  HIS F ND1   1 
ATOM   2959 C CD2   . HIS F 1 57 ? -13.794 16.445  19.483 1.00 7.07  ? 57  HIS F CD2   1 
ATOM   2960 C CE1   . HIS F 1 57 ? -13.209 17.933  17.981 1.00 9.98  ? 57  HIS F CE1   1 
ATOM   2961 N NE2   . HIS F 1 57 ? -13.210 17.672  19.276 1.00 7.95  ? 57  HIS F NE2   1 
ATOM   2962 N N     . ALA F 1 58 ? -16.510 15.427  20.729 1.00 4.92  ? 58  ALA F N     1 
ATOM   2963 C CA    . ALA F 1 58 ? -16.521 15.407  22.185 1.00 15.91 ? 58  ALA F CA    1 
ATOM   2964 C C     . ALA F 1 58 ? -17.902 15.121  22.760 1.00 11.85 ? 58  ALA F C     1 
ATOM   2965 O O     . ALA F 1 58 ? -18.056 15.103  23.986 1.00 10.70 ? 58  ALA F O     1 
ATOM   2966 C CB    . ALA F 1 58 ? -16.005 16.739  22.735 1.00 13.35 ? 58  ALA F CB    1 
ATOM   2967 N N     . ILE F 1 59 ? -18.901 14.902  21.913 1.00 1.43  ? 59  ILE F N     1 
ATOM   2968 C CA    . ILE F 1 59 ? -20.255 14.602  22.362 1.00 12.82 ? 59  ILE F CA    1 
ATOM   2969 C C     . ILE F 1 59 ? -20.420 13.093  22.460 1.00 14.56 ? 59  ILE F C     1 
ATOM   2970 O O     . ILE F 1 59 ? -19.969 12.344  21.586 1.00 5.79  ? 59  ILE F O     1 
ATOM   2971 C CB    . ILE F 1 59 ? -21.299 15.209  21.406 1.00 11.82 ? 59  ILE F CB    1 
ATOM   2972 C CG1   . ILE F 1 59 ? -21.250 16.739  21.457 1.00 13.78 ? 59  ILE F CG1   1 
ATOM   2973 C CG2   . ILE F 1 59 ? -22.691 14.702  21.753 1.00 5.91  ? 59  ILE F CG2   1 
ATOM   2974 C CD1   . ILE F 1 59 ? -22.088 17.415  20.389 1.00 10.87 ? 59  ILE F CD1   1 
ATOM   2975 N N     . SER F 1 60 ? -21.069 12.643  23.533 1.00 17.20 ? 60  SER F N     1 
ATOM   2976 C CA    . SER F 1 60 ? -21.420 11.237  23.697 1.00 16.64 ? 60  SER F CA    1 
ATOM   2977 C C     . SER F 1 60 ? -22.892 10.998  23.375 1.00 12.32 ? 60  SER F C     1 
ATOM   2978 O O     . SER F 1 60 ? -23.218 10.189  22.501 1.00 10.01 ? 60  SER F O     1 
ATOM   2979 C CB    . SER F 1 60 ? -21.100 10.773  25.124 1.00 8.31  ? 60  SER F CB    1 
ATOM   2980 O OG    . SER F 1 60 ? -22.058 11.254  26.048 1.00 17.33 ? 60  SER F OG    1 
ATOM   2981 N N     . THR F 1 61 ? -23.765 11.757  24.029 1.00 12.54 ? 61  THR F N     1 
ATOM   2982 C CA    . THR F 1 61 ? -25.226 11.654  23.832 1.00 17.21 ? 61  THR F CA    1 
ATOM   2983 C C     . THR F 1 61 ? -25.886 13.029  23.778 1.00 13.24 ? 61  THR F C     1 
ATOM   2984 O O     . THR F 1 61 ? -25.566 13.861  24.620 1.00 23.04 ? 61  THR F O     1 
ATOM   2985 C CB    . THR F 1 61 ? -25.902 10.810  24.933 1.00 8.13  ? 61  THR F CB    1 
ATOM   2986 O OG1   . THR F 1 61 ? -26.020 11.557  26.138 1.00 9.17  ? 61  THR F OG1   1 
ATOM   2987 C CG2   . THR F 1 61 ? -25.162 9.524   25.221 1.00 13.58 ? 61  THR F CG2   1 
ATOM   2988 N N     . VAL F 1 62 ? -26.770 13.240  22.819 1.00 25.06 ? 62  VAL F N     1 
ATOM   2989 C CA    . VAL F 1 62 ? -27.630 14.451  22.770 1.00 20.83 ? 62  VAL F CA    1 
ATOM   2990 C C     . VAL F 1 62 ? -29.032 13.938  23.101 1.00 20.06 ? 62  VAL F C     1 
ATOM   2991 O O     . VAL F 1 62 ? -29.510 13.108  22.340 1.00 16.85 ? 62  VAL F O     1 
ATOM   2992 C CB    . VAL F 1 62 ? -27.577 15.215  21.437 1.00 31.07 ? 62  VAL F CB    1 
ATOM   2993 C CG1   . VAL F 1 62 ? -27.660 14.325  20.215 1.00 28.68 ? 62  VAL F CG1   1 
ATOM   2994 C CG2   . VAL F 1 62 ? -28.667 16.269  21.391 1.00 34.25 ? 62  VAL F CG2   1 
ATOM   2995 N N     . VAL F 1 63 ? -29.603 14.341  24.228 1.00 18.54 ? 63  VAL F N     1 
ATOM   2996 C CA    . VAL F 1 63 ? -30.926 13.883  24.730 1.00 18.74 ? 63  VAL F CA    1 
ATOM   2997 C C     . VAL F 1 63 ? -31.936 15.032  24.846 1.00 17.49 ? 63  VAL F C     1 
ATOM   2998 O O     . VAL F 1 63 ? -31.598 16.080  25.360 1.00 18.04 ? 63  VAL F O     1 
ATOM   2999 C CB    . VAL F 1 63 ? -30.765 13.225  26.114 1.00 34.33 ? 63  VAL F CB    1 
ATOM   3000 C CG1   . VAL F 1 63 ? -30.024 14.100  27.103 1.00 29.66 ? 63  VAL F CG1   1 
ATOM   3001 C CG2   . VAL F 1 63 ? -32.101 12.783  26.684 1.00 28.45 ? 63  VAL F CG2   1 
ATOM   3002 N N     . PRO F 1 64 ? -33.206 14.834  24.453 1.00 30.95 ? 64  PRO F N     1 
ATOM   3003 C CA    . PRO F 1 64 ? -34.232 15.856  24.637 1.00 26.02 ? 64  PRO F CA    1 
ATOM   3004 C C     . PRO F 1 64 ? -34.827 15.770  26.046 1.00 25.26 ? 64  PRO F C     1 
ATOM   3005 O O     . PRO F 1 64 ? -34.963 14.675  26.531 1.00 30.13 ? 64  PRO F O     1 
ATOM   3006 C CB    . PRO F 1 64 ? -35.224 15.520  23.544 1.00 18.76 ? 64  PRO F CB    1 
ATOM   3007 C CG    . PRO F 1 64 ? -35.206 14.014  23.518 1.00 32.74 ? 64  PRO F CG    1 
ATOM   3008 C CD    . PRO F 1 64 ? -33.772 13.633  23.833 1.00 27.99 ? 64  PRO F CD    1 
ATOM   3009 N N     . SER F 1 65 ? -35.065 16.897  26.684 1.00 12.99 ? 65  SER F N     1 
ATOM   3010 C CA    . SER F 1 65 ? -35.742 17.010  27.993 1.00 25.82 ? 65  SER F CA    1 
ATOM   3011 C C     . SER F 1 65 ? -37.148 16.395  27.954 1.00 39.91 ? 65  SER F C     1 
ATOM   3012 O O     . SER F 1 65 ? -37.720 16.193  29.028 1.00 30.76 ? 65  SER F O     1 
ATOM   3013 C CB    . SER F 1 65 ? -35.851 18.459  28.325 1.00 34.49 ? 65  SER F CB    1 
ATOM   3014 O OG    . SER F 1 65 ? -36.605 19.148  27.343 1.00 25.81 ? 65  SER F OG    1 
ATOM   3015 N N     . ARG F 1 66 ? -37.697 16.164  26.764 1.00 22.88 ? 66  ARG F N     1 
ATOM   3016 C CA    . ARG F 1 66 ? -39.024 15.541  26.613 1.00 27.89 ? 66  ARG F CA    1 
ATOM   3017 C C     . ARG F 1 66 ? -39.098 14.801  25.284 1.00 34.55 ? 66  ARG F C     1 
ATOM   3018 O O     . ARG F 1 66 ? -38.301 15.118  24.399 1.00 26.78 ? 66  ARG F O     1 
ATOM   3019 C CB    . ARG F 1 66 ? -40.116 16.603  26.666 1.00 41.98 ? 66  ARG F CB    1 
ATOM   3020 C CG    . ARG F 1 66 ? -39.888 17.778  25.727 1.00 40.92 ? 66  ARG F CG    1 
ATOM   3021 C CD    . ARG F 1 66 ? -41.155 18.594  25.579 1.00 46.80 ? 66  ARG F CD    1 
ATOM   3022 N NE    . ARG F 1 66 ? -40.915 19.897  24.979 1.00 50.60 ? 66  ARG F NE    1 
ATOM   3023 C CZ    . ARG F 1 66 ? -40.346 20.927  25.594 1.00 46.31 ? 66  ARG F CZ    1 
ATOM   3024 N NH1   . ARG F 1 66 ? -39.898 20.811  26.831 1.00 51.87 ? 66  ARG F NH1   1 
ATOM   3025 N NH2   . ARG F 1 66 ? -40.210 22.076  24.959 1.00 29.36 ? 66  ARG F NH2   1 
ATOM   3026 N N     . PRO F 1 67 ? -40.068 13.878  25.093 1.00 37.55 ? 67  PRO F N     1 
ATOM   3027 C CA    . PRO F 1 67 ? -40.211 13.203  23.794 1.00 26.78 ? 67  PRO F CA    1 
ATOM   3028 C C     . PRO F 1 67 ? -40.512 14.205  22.685 1.00 42.94 ? 67  PRO F C     1 
ATOM   3029 O O     . PRO F 1 67 ? -41.299 15.136  22.866 1.00 47.30 ? 67  PRO F O     1 
ATOM   3030 C CB    . PRO F 1 67 ? -41.377 12.230  24.020 1.00 39.29 ? 67  PRO F CB    1 
ATOM   3031 C CG    . PRO F 1 67 ? -41.479 12.074  25.511 1.00 29.60 ? 67  PRO F CG    1 
ATOM   3032 C CD    . PRO F 1 67 ? -41.022 13.375  26.099 1.00 27.76 ? 67  PRO F CD    1 
ATOM   3033 N N     . VAL F 1 68 ? -39.866 14.015  21.530 1.00 34.19 ? 68  VAL F N     1 
ATOM   3034 C CA    . VAL F 1 68 ? -39.991 14.962  20.421 1.00 46.06 ? 68  VAL F CA    1 
ATOM   3035 C C     . VAL F 1 68 ? -40.782 14.364  19.259 1.00 55.80 ? 68  VAL F C     1 
ATOM   3036 O O     . VAL F 1 68 ? -40.219 13.879  18.275 1.00 54.73 ? 68  VAL F O     1 
ATOM   3037 C CB    . VAL F 1 68 ? -38.606 15.462  19.960 1.00 48.79 ? 68  VAL F CB    1 
ATOM   3038 C CG1   . VAL F 1 68 ? -37.818 15.966  21.150 1.00 31.47 ? 68  VAL F CG1   1 
ATOM   3039 C CG2   . VAL F 1 68 ? -37.821 14.364  19.264 1.00 71.37 ? 68  VAL F CG2   1 
ATOM   3040 P P     . A   G 2 1  ? -14.011 19.109  35.829 1.00 24.11 ? 1   A   Q P     1 
ATOM   3041 O OP1   . A   G 2 1  ? -13.101 18.268  35.010 1.00 24.44 ? 1   A   Q OP1   1 
ATOM   3042 O OP2   . A   G 2 1  ? -14.762 18.501  36.957 1.00 27.71 ? 1   A   Q OP2   1 
ATOM   3043 O "O5'" . A   G 2 1  ? -13.183 20.347  36.398 1.00 23.68 ? 1   A   Q "O5'" 1 
ATOM   3044 C "C5'" . A   G 2 1  ? -11.985 20.785  35.763 1.00 13.61 ? 1   A   Q "C5'" 1 
ATOM   3045 C "C4'" . A   G 2 1  ? -11.172 21.672  36.673 1.00 23.36 ? 1   A   Q "C4'" 1 
ATOM   3046 O "O4'" . A   G 2 1  ? -11.007 21.006  37.956 1.00 26.08 ? 1   A   Q "O4'" 1 
ATOM   3047 C "C3'" . A   G 2 1  ? -9.763  21.996  36.184 1.00 27.38 ? 1   A   Q "C3'" 1 
ATOM   3048 O "O3'" . A   G 2 1  ? -9.387  23.292  36.650 1.00 30.24 ? 1   A   Q "O3'" 1 
ATOM   3049 C "C2'" . A   G 2 1  ? -8.920  20.936  36.885 1.00 23.57 ? 1   A   Q "C2'" 1 
ATOM   3050 O "O2'" . A   G 2 1  ? -7.555  21.263  37.029 1.00 22.84 ? 1   A   Q "O2'" 1 
ATOM   3051 C "C1'" . A   G 2 1  ? -9.628  20.841  38.233 1.00 23.81 ? 1   A   Q "C1'" 1 
ATOM   3052 N N9    . A   G 2 1  ? -9.443  19.567  38.932 1.00 20.93 ? 1   A   Q N9    1 
ATOM   3053 C C8    . A   G 2 1  ? -9.700  18.297  38.481 1.00 30.48 ? 1   A   Q C8    1 
ATOM   3054 N N7    . A   G 2 1  ? -9.429  17.361  39.359 1.00 32.56 ? 1   A   Q N7    1 
ATOM   3055 C C5    . A   G 2 1  ? -8.966  18.065  40.464 1.00 27.38 ? 1   A   Q C5    1 
ATOM   3056 C C6    . A   G 2 1  ? -8.514  17.656  41.731 1.00 30.72 ? 1   A   Q C6    1 
ATOM   3057 N N6    . A   G 2 1  ? -8.450  16.380  42.119 1.00 38.54 ? 1   A   Q N6    1 
ATOM   3058 N N1    . A   G 2 1  ? -8.123  18.615  42.599 1.00 25.07 ? 1   A   Q N1    1 
ATOM   3059 C C2    . A   G 2 1  ? -8.185  19.895  42.213 1.00 33.83 ? 1   A   Q C2    1 
ATOM   3060 N N3    . A   G 2 1  ? -8.591  20.403  41.052 1.00 21.95 ? 1   A   Q N3    1 
ATOM   3061 C C4    . A   G 2 1  ? -8.973  19.424  40.214 1.00 27.36 ? 1   A   Q C4    1 
ATOM   3062 P P     . A   G 2 2  ? -9.196  24.510  35.621 1.00 22.40 ? 2   A   Q P     1 
ATOM   3063 O OP1   . A   G 2 2  ? -9.585  25.760  36.324 1.00 29.98 ? 2   A   Q OP1   1 
ATOM   3064 O OP2   . A   G 2 2  ? -9.853  24.154  34.335 1.00 14.42 ? 2   A   Q OP2   1 
ATOM   3065 O "O5'" . A   G 2 2  ? -7.622  24.560  35.387 1.00 34.18 ? 2   A   Q "O5'" 1 
ATOM   3066 C "C5'" . A   G 2 2  ? -7.065  25.340  34.336 1.00 25.63 ? 2   A   Q "C5'" 1 
ATOM   3067 C "C4'" . A   G 2 2  ? -5.592  25.069  34.154 1.00 14.06 ? 2   A   Q "C4'" 1 
ATOM   3068 O "O4'" . A   G 2 2  ? -5.176  25.598  32.866 1.00 13.37 ? 2   A   Q "O4'" 1 
ATOM   3069 C "C3'" . A   G 2 2  ? -4.674  25.719  35.184 1.00 24.59 ? 2   A   Q "C3'" 1 
ATOM   3070 O "O3'" . A   G 2 2  ? -3.496  24.922  35.323 1.00 8.15  ? 2   A   Q "O3'" 1 
ATOM   3071 C "C2'" . A   G 2 2  ? -4.326  27.044  34.515 1.00 13.95 ? 2   A   Q "C2'" 1 
ATOM   3072 O "O2'" . A   G 2 2  ? -3.144  27.655  34.987 1.00 15.54 ? 2   A   Q "O2'" 1 
ATOM   3073 C "C1'" . A   G 2 2  ? -4.204  26.613  33.055 1.00 11.81 ? 2   A   Q "C1'" 1 
ATOM   3074 N N9    . A   G 2 2  ? -4.470  27.666  32.073 1.00 20.34 ? 2   A   Q N9    1 
ATOM   3075 C C8    . A   G 2 2  ? -5.672  28.263  31.786 1.00 12.33 ? 2   A   Q C8    1 
ATOM   3076 N N7    . A   G 2 2  ? -5.603  29.164  30.837 1.00 24.21 ? 2   A   Q N7    1 
ATOM   3077 C C5    . A   G 2 2  ? -4.265  29.149  30.466 1.00 27.63 ? 2   A   Q C5    1 
ATOM   3078 C C6    . A   G 2 2  ? -3.539  29.877  29.508 1.00 19.42 ? 2   A   Q C6    1 
ATOM   3079 N N6    . A   G 2 2  ? -4.078  30.800  28.709 1.00 32.33 ? 2   A   Q N6    1 
ATOM   3080 N N1    . A   G 2 2  ? -2.218  29.618  29.390 1.00 24.79 ? 2   A   Q N1    1 
ATOM   3081 C C2    . A   G 2 2  ? -1.673  28.692  30.187 1.00 23.80 ? 2   A   Q C2    1 
ATOM   3082 N N3    . A   G 2 2  ? -2.249  27.945  31.125 1.00 19.88 ? 2   A   Q N3    1 
ATOM   3083 C C4    . A   G 2 2  ? -3.560  28.224  31.212 1.00 26.12 ? 2   A   Q C4    1 
ATOM   3084 P P     . A   G 2 3  ? -3.188  24.129  36.687 1.00 14.35 ? 3   A   Q P     1 
ATOM   3085 O OP1   . A   G 2 3  ? -4.249  24.448  37.674 1.00 5.90  ? 3   A   Q OP1   1 
ATOM   3086 O OP2   . A   G 2 3  ? -1.766  24.380  37.033 1.00 29.54 ? 3   A   Q OP2   1 
ATOM   3087 O "O5'" . A   G 2 3  ? -3.320  22.593  36.281 1.00 17.78 ? 3   A   Q "O5'" 1 
ATOM   3088 C "C5'" . A   G 2 3  ? -4.590  21.950  36.249 1.00 12.33 ? 3   A   Q "C5'" 1 
ATOM   3089 C "C4'" . A   G 2 3  ? -4.669  20.917  35.152 1.00 18.32 ? 3   A   Q "C4'" 1 
ATOM   3090 O "O4'" . A   G 2 3  ? -4.651  21.587  33.860 1.00 4.14  ? 3   A   Q "O4'" 1 
ATOM   3091 C "C3'" . A   G 2 3  ? -3.523  19.907  35.121 1.00 20.52 ? 3   A   Q "C3'" 1 
ATOM   3092 O "O3'" . A   G 2 3  ? -4.006  18.642  34.671 1.00 23.00 ? 3   A   Q "O3'" 1 
ATOM   3093 C "C2'" . A   G 2 3  ? -2.586  20.498  34.073 1.00 18.06 ? 3   A   Q "C2'" 1 
ATOM   3094 O "O2'" . A   G 2 3  ? -1.720  19.565  33.462 1.00 28.30 ? 3   A   Q "O2'" 1 
ATOM   3095 C "C1'" . A   G 2 3  ? -3.585  21.084  33.079 1.00 9.59  ? 3   A   Q "C1'" 1 
ATOM   3096 N N9    . A   G 2 3  ? -3.057  22.171  32.251 1.00 20.77 ? 3   A   Q N9    1 
ATOM   3097 C C8    . A   G 2 3  ? -2.404  23.311  32.647 1.00 6.48  ? 3   A   Q C8    1 
ATOM   3098 N N7    . A   G 2 3  ? -2.058  24.092  31.651 1.00 14.86 ? 3   A   Q N7    1 
ATOM   3099 C C5    . A   G 2 3  ? -2.513  23.421  30.524 1.00 3.22  ? 3   A   Q C5    1 
ATOM   3100 C C6    . A   G 2 3  ? -2.462  23.723  29.152 1.00 14.10 ? 3   A   Q C6    1 
ATOM   3101 N N6    . A   G 2 3  ? -1.900  24.828  28.655 1.00 16.17 ? 3   A   Q N6    1 
ATOM   3102 N N1    . A   G 2 3  ? -3.015  22.839  28.292 1.00 13.55 ? 3   A   Q N1    1 
ATOM   3103 C C2    . A   G 2 3  ? -3.580  21.732  28.787 1.00 8.41  ? 3   A   Q C2    1 
ATOM   3104 N N3    . A   G 2 3  ? -3.691  21.340  30.054 1.00 11.56 ? 3   A   Q N3    1 
ATOM   3105 C C4    . A   G 2 3  ? -3.136  22.240  30.881 1.00 10.35 ? 3   A   Q C4    1 
ATOM   3106 P P     . A   G 2 4  ? -4.236  17.428  35.680 1.00 18.06 ? 4   A   Q P     1 
ATOM   3107 O OP1   . A   G 2 4  ? -4.636  16.321  34.773 1.00 11.68 ? 4   A   Q OP1   1 
ATOM   3108 O OP2   . A   G 2 4  ? -5.194  17.758  36.772 1.00 35.85 ? 4   A   Q OP2   1 
ATOM   3109 O "O5'" . A   G 2 4  ? -2.804  17.186  36.364 1.00 34.56 ? 4   A   Q "O5'" 1 
ATOM   3110 C "C5'" . A   G 2 4  ? -1.805  16.374  35.712 1.00 14.33 ? 4   A   Q "C5'" 1 
ATOM   3111 C "C4'" . A   G 2 4  ? -0.717  16.073  36.711 1.00 31.87 ? 4   A   Q "C4'" 1 
ATOM   3112 O "O4'" . A   G 2 4  ? -1.309  15.669  37.975 1.00 26.20 ? 4   A   Q "O4'" 1 
ATOM   3113 C "C3'" . A   G 2 4  ? 0.246   14.941  36.338 1.00 37.59 ? 4   A   Q "C3'" 1 
ATOM   3114 O "O3'" . A   G 2 4  ? 1.549   15.239  36.818 1.00 30.74 ? 4   A   Q "O3'" 1 
ATOM   3115 C "C2'" . A   G 2 4  ? -0.350  13.755  37.084 1.00 28.20 ? 4   A   Q "C2'" 1 
ATOM   3116 O "O2'" . A   G 2 4  ? 0.577   12.713  37.275 1.00 30.58 ? 4   A   Q "O2'" 1 
ATOM   3117 C "C1'" . A   G 2 4  ? -0.722  14.456  38.380 1.00 30.46 ? 4   A   Q "C1'" 1 
ATOM   3118 N N9    . A   G 2 4  ? -1.651  13.689  39.194 1.00 38.40 ? 4   A   Q N9    1 
ATOM   3119 C C8    . A   G 2 4  ? -2.896  13.241  38.840 1.00 26.99 ? 4   A   Q C8    1 
ATOM   3120 N N7    . A   G 2 4  ? -3.478  12.540  39.778 1.00 29.98 ? 4   A   Q N7    1 
ATOM   3121 C C5    . A   G 2 4  ? -2.554  12.509  40.810 1.00 35.54 ? 4   A   Q C5    1 
ATOM   3122 C C6    . A   G 2 4  ? -2.574  11.917  42.087 1.00 39.22 ? 4   A   Q C6    1 
ATOM   3123 N N6    . A   G 2 4  ? -3.597  11.219  42.567 1.00 25.20 ? 4   A   Q N6    1 
ATOM   3124 N N1    . A   G 2 4  ? -1.480  12.081  42.866 1.00 28.39 ? 4   A   Q N1    1 
ATOM   3125 C C2    . A   G 2 4  ? -0.453  12.789  42.388 1.00 28.83 ? 4   A   Q C2    1 
ATOM   3126 N N3    . A   G 2 4  ? -0.323  13.387  41.209 1.00 30.38 ? 4   A   Q N3    1 
ATOM   3127 C C4    . A   G 2 4  ? -1.419  13.208  40.458 1.00 36.01 ? 4   A   Q C4    1 
ATOM   3128 P P     . A   G 2 5  ? 2.485   15.746  35.624 1.00 23.53 ? 5   A   Q P     1 
ATOM   3129 O OP1   . A   G 2 5  ? 3.573   16.646  36.114 1.00 41.72 ? 5   A   Q OP1   1 
ATOM   3130 O OP2   . A   G 2 5  ? 1.646   16.341  34.566 1.00 16.15 ? 5   A   Q OP2   1 
ATOM   3131 O "O5'" . A   G 2 5  ? 3.160   14.396  35.091 1.00 32.63 ? 5   A   Q "O5'" 1 
ATOM   3132 C "C5'" . A   G 2 5  ? 4.060   14.436  33.963 1.00 23.73 ? 5   A   Q "C5'" 1 
ATOM   3133 C "C4'" . A   G 2 5  ? 4.631   13.053  33.780 1.00 20.03 ? 5   A   Q "C4'" 1 
ATOM   3134 O "O4'" . A   G 2 5  ? 5.352   12.986  32.524 1.00 9.96  ? 5   A   Q "O4'" 1 
ATOM   3135 C "C3'" . A   G 2 5  ? 5.645   12.614  34.843 1.00 10.74 ? 5   A   Q "C3'" 1 
ATOM   3136 O "O3'" . A   G 2 5  ? 5.654   11.201  34.989 1.00 32.10 ? 5   A   Q "O3'" 1 
ATOM   3137 C "C2'" . A   G 2 5  ? 6.945   13.128  34.226 1.00 20.09 ? 5   A   Q "C2'" 1 
ATOM   3138 O "O2'" . A   G 2 5  ? 8.107   12.544  34.772 1.00 19.54 ? 5   A   Q "O2'" 1 
ATOM   3139 C "C1'" . A   G 2 5  ? 6.707   12.702  32.784 1.00 19.00 ? 5   A   Q "C1'" 1 
ATOM   3140 N N9    . A   G 2 5  ? 7.515   13.401  31.797 1.00 18.52 ? 5   A   Q N9    1 
ATOM   3141 C C8    . A   G 2 5  ? 7.357   14.687  31.354 1.00 26.04 ? 5   A   Q C8    1 
ATOM   3142 N N7    . A   G 2 5  ? 8.219   15.027  30.432 1.00 20.02 ? 5   A   Q N7    1 
ATOM   3143 C C5    . A   G 2 5  ? 8.983   13.889  30.239 1.00 24.69 ? 5   A   Q C5    1 
ATOM   3144 C C6    . A   G 2 5  ? 10.066  13.605  29.387 1.00 32.52 ? 5   A   Q C6    1 
ATOM   3145 N N6    . A   G 2 5  ? 10.588  14.476  28.527 1.00 35.79 ? 5   A   Q N6    1 
ATOM   3146 N N1    . A   G 2 5  ? 10.591  12.360  29.447 1.00 22.99 ? 5   A   Q N1    1 
ATOM   3147 C C2    . A   G 2 5  ? 10.065  11.481  30.307 1.00 24.34 ? 5   A   Q C2    1 
ATOM   3148 N N3    . A   G 2 5  ? 9.052   11.634  31.152 1.00 25.01 ? 5   A   Q N3    1 
ATOM   3149 C C4    . A   G 2 5  ? 8.547   12.874  31.068 1.00 25.53 ? 5   A   Q C4    1 
ATOM   3150 P P     . A   G 2 6  ? 5.269   10.579  36.416 1.00 17.63 ? 6   A   Q P     1 
ATOM   3151 O OP1   . A   G 2 6  ? 5.058   11.571  37.514 1.00 18.57 ? 6   A   Q OP1   1 
ATOM   3152 O OP2   . A   G 2 6  ? 6.232   9.488   36.778 1.00 29.86 ? 6   A   Q OP2   1 
ATOM   3153 O "O5'" . A   G 2 6  ? 3.868   9.861   36.109 1.00 19.82 ? 6   A   Q "O5'" 1 
ATOM   3154 C "C5'" . A   G 2 6  ? 2.646   10.625  36.135 1.00 8.21  ? 6   A   Q "C5'" 1 
ATOM   3155 C "C4'" . A   G 2 6  ? 1.759   10.183  35.001 1.00 9.96  ? 6   A   Q "C4'" 1 
ATOM   3156 O "O4'" . A   G 2 6  ? 2.419   10.516  33.756 1.00 13.76 ? 6   A   Q "O4'" 1 
ATOM   3157 C "C3'" . A   G 2 6  ? 1.438   8.680   34.918 1.00 14.16 ? 6   A   Q "C3'" 1 
ATOM   3158 O "O3'" . A   G 2 6  ? 0.110   8.432   34.467 1.00 24.02 ? 6   A   Q "O3'" 1 
ATOM   3159 C "C2'" . A   G 2 6  ? 2.452   8.199   33.878 1.00 31.28 ? 6   A   Q "C2'" 1 
ATOM   3160 O "O2'" . A   G 2 6  ? 2.079   7.033   33.184 1.00 19.55 ? 6   A   Q "O2'" 1 
ATOM   3161 C "C1'" . A   G 2 6  ? 2.449   9.385   32.926 1.00 17.79 ? 6   A   Q "C1'" 1 
ATOM   3162 N N9    . A   G 2 6  ? 3.620   9.461   32.068 1.00 26.61 ? 6   A   Q N9    1 
ATOM   3163 C C8    . A   G 2 6  ? 4.933   9.439   32.457 1.00 9.46  ? 6   A   Q C8    1 
ATOM   3164 N N7    . A   G 2 6  ? 5.771   9.523   31.459 1.00 13.41 ? 6   A   Q N7    1 
ATOM   3165 C C5    . A   G 2 6  ? 4.962   9.603   30.338 1.00 7.85  ? 6   A   Q C5    1 
ATOM   3166 C C6    . A   G 2 6  ? 5.251   9.714   28.966 1.00 11.43 ? 6   A   Q C6    1 
ATOM   3167 N N6    . A   G 2 6  ? 6.483   9.775   28.470 1.00 15.73 ? 6   A   Q N6    1 
ATOM   3168 N N1    . A   G 2 6  ? 4.201   9.789   28.116 1.00 9.69  ? 6   A   Q N1    1 
ATOM   3169 C C2    . A   G 2 6  ? 2.965   9.727   28.614 1.00 6.19  ? 6   A   Q C2    1 
ATOM   3170 N N3    . A   G 2 6  ? 2.576   9.623   29.879 1.00 13.38 ? 6   A   Q N3    1 
ATOM   3171 C C4    . A   G 2 6  ? 3.631   9.565   30.701 1.00 14.70 ? 6   A   Q C4    1 
ATOM   3172 P P     . A   G 2 7  ? -1.048  8.140   35.544 1.00 23.64 ? 7   A   Q P     1 
ATOM   3173 O OP1   . A   G 2 7  ? -2.268  7.799   34.769 1.00 30.51 ? 7   A   Q OP1   1 
ATOM   3174 O OP2   . A   G 2 7  ? -1.100  9.233   36.548 1.00 42.22 ? 7   A   Q OP2   1 
ATOM   3175 O "O5'" . A   G 2 7  ? -0.542  6.814   36.269 1.00 35.30 ? 7   A   Q "O5'" 1 
ATOM   3176 C "C5'" . A   G 2 7  ? -0.707  5.538   35.659 1.00 22.02 ? 7   A   Q "C5'" 1 
ATOM   3177 C "C4'" . A   G 2 7  ? -0.283  4.420   36.579 1.00 25.74 ? 7   A   Q "C4'" 1 
ATOM   3178 O "O4'" . A   G 2 7  ? -0.868  4.637   37.894 1.00 18.83 ? 7   A   Q "O4'" 1 
ATOM   3179 C "C3'" . A   G 2 7  ? -0.725  3.023   36.149 1.00 15.28 ? 7   A   Q "C3'" 1 
ATOM   3180 O "O3'" . A   G 2 7  ? 0.241   2.062   36.576 1.00 31.19 ? 7   A   Q "O3'" 1 
ATOM   3181 C "C2'" . A   G 2 7  ? -2.019  2.832   36.933 1.00 24.89 ? 7   A   Q "C2'" 1 
ATOM   3182 O "O2'" . A   G 2 7  ? -2.398  1.487   37.130 1.00 32.41 ? 7   A   Q "O2'" 1 
ATOM   3183 C "C1'" . A   G 2 7  ? -1.670  3.524   38.247 1.00 31.24 ? 7   A   Q "C1'" 1 
ATOM   3184 N N9    . A   G 2 7  ? -2.820  4.006   39.015 1.00 35.61 ? 7   A   Q N9    1 
ATOM   3185 C C8    . A   G 2 7  ? -3.730  4.977   38.679 1.00 29.01 ? 7   A   Q C8    1 
ATOM   3186 N N7    . A   G 2 7  ? -4.641  5.185   39.600 1.00 31.02 ? 7   A   Q N7    1 
ATOM   3187 C C5    . A   G 2 7  ? -4.302  4.295   40.610 1.00 23.18 ? 7   A   Q C5    1 
ATOM   3188 C C6    . A   G 2 7  ? -4.874  4.018   41.865 1.00 28.49 ? 7   A   Q C6    1 
ATOM   3189 N N6    . A   G 2 7  ? -5.957  4.637   42.339 1.00 27.26 ? 7   A   Q N6    1 
ATOM   3190 N N1    . A   G 2 7  ? -4.288  3.069   42.628 1.00 20.56 ? 7   A   Q N1    1 
ATOM   3191 C C2    . A   G 2 7  ? -3.202  2.445   42.156 1.00 20.26 ? 7   A   Q C2    1 
ATOM   3192 N N3    . A   G 2 7  ? -2.573  2.618   40.997 1.00 28.58 ? 7   A   Q N3    1 
ATOM   3193 C C4    . A   G 2 7  ? -3.179  3.568   40.264 1.00 28.80 ? 7   A   Q C4    1 
ATOM   3194 P P     . A   G 2 8  ? 1.175   1.313   35.505 1.00 21.95 ? 8   A   Q P     1 
ATOM   3195 O OP1   . A   G 2 8  ? 2.465   1.006   36.174 1.00 42.13 ? 8   A   Q OP1   1 
ATOM   3196 O OP2   . A   G 2 8  ? 1.176   2.108   34.250 1.00 15.73 ? 8   A   Q OP2   1 
ATOM   3197 O "O5'" . A   G 2 8  ? 0.423   -0.067  35.234 1.00 27.21 ? 8   A   Q "O5'" 1 
ATOM   3198 C "C5'" . A   G 2 8  ? 0.788   -0.891  34.132 1.00 37.81 ? 8   A   Q "C5'" 1 
ATOM   3199 C "C4'" . A   G 2 8  ? -0.073  -2.128  34.034 1.00 19.03 ? 8   A   Q "C4'" 1 
ATOM   3200 O "O4'" . A   G 2 8  ? 0.162   -2.760  32.747 1.00 17.21 ? 8   A   Q "O4'" 1 
ATOM   3201 C "C3'" . A   G 2 8  ? 0.202   -3.204  35.081 1.00 22.79 ? 8   A   Q "C3'" 1 
ATOM   3202 O "O3'" . A   G 2 8  ? -0.995  -3.937  35.339 1.00 22.13 ? 8   A   Q "O3'" 1 
ATOM   3203 C "C2'" . A   G 2 8  ? 1.196   -4.111  34.365 1.00 28.23 ? 8   A   Q "C2'" 1 
ATOM   3204 O "O2'" . A   G 2 8  ? 1.258   -5.428  34.869 1.00 23.06 ? 8   A   Q "O2'" 1 
ATOM   3205 C "C1'" . A   G 2 8  ? 0.652   -4.076  32.940 1.00 18.41 ? 8   A   Q "C1'" 1 
ATOM   3206 N N9    . A   G 2 8  ? 1.639   -4.358  31.894 1.00 31.28 ? 8   A   Q N9    1 
ATOM   3207 C C8    . A   G 2 8  ? 2.749   -3.628  31.547 1.00 19.89 ? 8   A   Q C8    1 
ATOM   3208 N N7    . A   G 2 8  ? 3.433   -4.143  30.552 1.00 24.95 ? 8   A   Q N7    1 
ATOM   3209 C C5    . A   G 2 8  ? 2.721   -5.286  30.214 1.00 28.34 ? 8   A   Q C5    1 
ATOM   3210 C C6    . A   G 2 8  ? 2.922   -6.278  29.236 1.00 30.78 ? 8   A   Q C6    1 
ATOM   3211 N N6    . A   G 2 8  ? 3.943   -6.282  28.376 1.00 24.95 ? 8   A   Q N6    1 
ATOM   3212 N N1    . A   G 2 8  ? 2.022   -7.284  29.167 1.00 33.40 ? 8   A   Q N1    1 
ATOM   3213 C C2    . A   G 2 8  ? 0.996   -7.285  30.026 1.00 21.77 ? 8   A   Q C2    1 
ATOM   3214 N N3    . A   G 2 8  ? 0.702   -6.412  30.986 1.00 16.86 ? 8   A   Q N3    1 
ATOM   3215 C C4    . A   G 2 8  ? 1.612   -5.425  31.028 1.00 25.95 ? 8   A   Q C4    1 
ATOM   3216 P P     . A   G 2 9  ? -1.985  -3.408  36.486 1.00 26.95 ? 9   A   Q P     1 
ATOM   3217 O OP1   . A   G 2 9  ? -1.297  -3.245  37.806 1.00 17.08 ? 9   A   Q OP1   1 
ATOM   3218 O OP2   . A   G 2 9  ? -3.199  -4.274  36.552 1.00 44.42 ? 9   A   Q OP2   1 
ATOM   3219 O "O5'" . A   G 2 9  ? -2.451  -1.958  35.980 1.00 45.84 ? 9   A   Q "O5'" 1 
ATOM   3220 C "C5'" . A   G 2 9  ? -3.768  -1.468  36.309 1.00 17.24 ? 9   A   Q "C5'" 1 
ATOM   3221 C "C4'" . A   G 2 9  ? -4.405  -0.908  35.065 1.00 20.84 ? 9   A   Q "C4'" 1 
ATOM   3222 O "O4'" . A   G 2 9  ? -3.648  -1.335  33.904 1.00 7.29  ? 9   A   Q "O4'" 1 
ATOM   3223 C "C3'" . A   G 2 9  ? -5.853  -1.353  34.816 1.00 24.47 ? 9   A   Q "C3'" 1 
ATOM   3224 O "O3'" . A   G 2 9  ? -6.664  -0.316  34.278 1.00 15.31 ? 9   A   Q "O3'" 1 
ATOM   3225 C "C2'" . A   G 2 9  ? -5.661  -2.469  33.790 1.00 18.67 ? 9   A   Q "C2'" 1 
ATOM   3226 O "O2'" . A   G 2 9  ? -6.772  -2.684  32.961 1.00 24.72 ? 9   A   Q "O2'" 1 
ATOM   3227 C "C1'" . A   G 2 9  ? -4.532  -1.885  32.961 1.00 17.99 ? 9   A   Q "C1'" 1 
ATOM   3228 N N9    . A   G 2 9  ? -3.857  -2.878  32.140 1.00 8.13  ? 9   A   Q N9    1 
ATOM   3229 C C8    . A   G 2 9  ? -3.190  -3.994  32.573 1.00 10.89 ? 9   A   Q C8    1 
ATOM   3230 N N7    . A   G 2 9  ? -2.706  -4.717  31.599 1.00 9.18  ? 9   A   Q N7    1 
ATOM   3231 C C5    . A   G 2 9  ? -3.083  -4.044  30.450 1.00 8.50  ? 9   A   Q C5    1 
ATOM   3232 C C6    . A   G 2 9  ? -2.862  -4.301  29.086 1.00 9.40  ? 9   A   Q C6    1 
ATOM   3233 N N6    . A   G 2 9  ? -2.189  -5.354  28.633 1.00 21.85 ? 9   A   Q N6    1 
ATOM   3234 N N1    . A   G 2 9  ? -3.377  -3.424  28.194 1.00 11.25 ? 9   A   Q N1    1 
ATOM   3235 C C2    . A   G 2 9  ? -4.049  -2.364  28.654 1.00 9.85  ? 9   A   Q C2    1 
ATOM   3236 N N3    . A   G 2 9  ? -4.321  -2.025  29.908 1.00 6.66  ? 9   A   Q N3    1 
ATOM   3237 C C4    . A   G 2 9  ? -3.801  -2.910  30.771 1.00 15.04 ? 9   A   Q C4    1 
ATOM   3238 P P     . A   G 2 10 ? -7.400  0.582   35.383 1.00 13.35 ? 10  A   Q P     1 
ATOM   3239 O OP1   . A   G 2 10 ? -8.280  1.603   34.760 1.00 15.10 ? 10  A   Q OP1   1 
ATOM   3240 O OP2   . A   G 2 10 ? -6.428  1.128   36.367 1.00 23.10 ? 10  A   Q OP2   1 
ATOM   3241 O "O5'" . A   G 2 10 ? -8.343  -0.448  36.175 1.00 39.08 ? 10  A   Q "O5'" 1 
ATOM   3242 C "C5'" . A   G 2 10 ? -9.597  -0.855  35.588 1.00 20.73 ? 10  A   Q "C5'" 1 
ATOM   3243 C "C4'" . A   G 2 10 ? -10.301 -1.782  36.543 1.00 25.07 ? 10  A   Q "C4'" 1 
ATOM   3244 O "O4'" . A   G 2 10 ? -10.417 -1.143  37.843 1.00 20.71 ? 10  A   Q "O4'" 1 
ATOM   3245 C "C3'" . A   G 2 10 ? -11.732 -2.165  36.161 1.00 27.61 ? 10  A   Q "C3'" 1 
ATOM   3246 O "O3'" . A   G 2 10 ? -12.051 -3.436  36.704 1.00 21.73 ? 10  A   Q "O3'" 1 
ATOM   3247 C "C2'" . A   G 2 10 ? -12.524 -1.056  36.847 1.00 29.21 ? 10  A   Q "C2'" 1 
ATOM   3248 O "O2'" . A   G 2 10 ? -13.887 -1.375  37.005 1.00 24.26 ? 10  A   Q "O2'" 1 
ATOM   3249 C "C1'" . A   G 2 10 ? -11.779 -1.012  38.176 1.00 27.83 ? 10  A   Q "C1'" 1 
ATOM   3250 N N9    . A   G 2 10 ? -11.957 0.216   38.938 1.00 25.95 ? 10  A   Q N9    1 
ATOM   3251 C C8    . A   G 2 10 ? -11.693 1.494   38.523 1.00 26.04 ? 10  A   Q C8    1 
ATOM   3252 N N7    . A   G 2 10 ? -11.944 2.398   39.436 1.00 30.06 ? 10  A   Q N7    1 
ATOM   3253 C C5    . A   G 2 10 ? -12.391 1.672   40.526 1.00 24.82 ? 10  A   Q C5    1 
ATOM   3254 C C6    . A   G 2 10 ? -12.817 2.059   41.811 1.00 35.94 ? 10  A   Q C6    1 
ATOM   3255 N N6    . A   G 2 10 ? -12.859 3.320   42.228 1.00 29.89 ? 10  A   Q N6    1 
ATOM   3256 N N1    . A   G 2 10 ? -13.208 1.079   42.657 1.00 32.01 ? 10  A   Q N1    1 
ATOM   3257 C C2    . A   G 2 10 ? -13.160 -0.188  42.232 1.00 33.67 ? 10  A   Q C2    1 
ATOM   3258 N N3    . A   G 2 10 ? -12.780 -0.667  41.053 1.00 23.45 ? 10  A   Q N3    1 
ATOM   3259 C C4    . A   G 2 10 ? -12.400 0.324   40.233 1.00 27.22 ? 10  A   Q C4    1 
ATOM   3260 P P     . A   G 2 11 ? -12.234 -4.554  35.575 1.00 26.84 ? 11  A   Q P     1 
ATOM   3261 O OP1   . A   G 2 11 ? -12.379 -5.905  36.212 1.00 33.59 ? 11  A   Q OP1   1 
ATOM   3262 O OP2   . A   G 2 11 ? -11.160 -4.459  34.542 1.00 12.46 ? 11  A   Q OP2   1 
ATOM   3263 O "O5'" . A   G 2 11 ? -13.646 -4.185  34.905 1.00 31.09 ? 11  A   Q "O5'" 1 
ATOM   3264 C "C5'" . A   G 2 11 ? -14.221 -5.088  33.936 1.00 23.11 ? 11  A   Q "C5'" 1 
ATOM   3265 C "C4'" . A   G 2 11 ? -15.707 -4.859  33.879 1.00 17.71 ? 11  A   Q "C4'" 1 
ATOM   3266 O "O4'" . A   G 2 11 ? -16.213 -5.407  32.640 1.00 19.96 ? 11  A   Q "O4'" 1 
ATOM   3267 C "C3'" . A   G 2 11 ? -16.526 -5.553  34.969 1.00 19.47 ? 11  A   Q "C3'" 1 
ATOM   3268 O "O3'" . A   G 2 11 ? -17.815 -4.987  35.140 1.00 27.07 ? 11  A   Q "O3'" 1 
ATOM   3269 C "C2'" . A   G 2 11 ? -16.696 -6.934  34.350 1.00 19.82 ? 11  A   Q "C2'" 1 
ATOM   3270 O "O2'" . A   G 2 11 ? -17.737 -7.698  34.912 1.00 24.05 ? 11  A   Q "O2'" 1 
ATOM   3271 C "C1'" . A   G 2 11 ? -17.033 -6.513  32.928 1.00 18.61 ? 11  A   Q "C1'" 1 
ATOM   3272 N N9    . A   G 2 11 ? -16.764 -7.553  31.959 1.00 24.36 ? 11  A   Q N9    1 
ATOM   3273 C C8    . A   G 2 11 ? -15.552 -8.125  31.702 1.00 15.05 ? 11  A   Q C8    1 
ATOM   3274 N N7    . A   G 2 11 ? -15.606 -9.046  30.779 1.00 33.30 ? 11  A   Q N7    1 
ATOM   3275 C C5    . A   G 2 11 ? -16.940 -9.082  30.410 1.00 25.11 ? 11  A   Q C5    1 
ATOM   3276 C C6    . A   G 2 11 ? -17.638 -9.861  29.477 1.00 19.34 ? 11  A   Q C6    1 
ATOM   3277 N N6    . A   G 2 11 ? -17.052 -10.777 28.720 1.00 32.42 ? 11  A   Q N6    1 
ATOM   3278 N N1    . A   G 2 11 ? -18.969 -9.655  29.356 1.00 15.02 ? 11  A   Q N1    1 
ATOM   3279 C C2    . A   G 2 11 ? -19.540 -8.723  30.125 1.00 11.83 ? 11  A   Q C2    1 
ATOM   3280 N N3    . A   G 2 11 ? -18.987 -7.937  31.039 1.00 8.39  ? 11  A   Q N3    1 
ATOM   3281 C C4    . A   G 2 11 ? -17.670 -8.168  31.135 1.00 24.22 ? 11  A   Q C4    1 
ATOM   3282 P P     . A   G 2 12 ? -18.129 -4.257  36.530 1.00 16.19 ? 12  A   Q P     1 
ATOM   3283 O OP1   . A   G 2 12 ? -17.166 -4.560  37.617 1.00 21.80 ? 12  A   Q OP1   1 
ATOM   3284 O OP2   . A   G 2 12 ? -19.549 -4.501  36.915 1.00 43.48 ? 12  A   Q OP2   1 
ATOM   3285 O "O5'" . A   G 2 12 ? -18.010 -2.704  36.128 1.00 29.50 ? 12  A   Q "O5'" 1 
ATOM   3286 C "C5'" . A   G 2 12 ? -16.719 -2.056  36.148 1.00 16.29 ? 12  A   Q "C5'" 1 
ATOM   3287 C "C4'" . A   G 2 12 ? -16.675 -0.967  35.103 1.00 17.20 ? 12  A   Q "C4'" 1 
ATOM   3288 O "O4'" . A   G 2 12 ? -16.679 -1.583  33.791 1.00 11.98 ? 12  A   Q "O4'" 1 
ATOM   3289 C "C3'" . A   G 2 12 ? -17.845 0.028   35.090 1.00 26.56 ? 12  A   Q "C3'" 1 
ATOM   3290 O "O3'" . A   G 2 12 ? -17.461 1.320   34.633 1.00 26.55 ? 12  A   Q "O3'" 1 
ATOM   3291 C "C2'" . A   G 2 12 ? -18.790 -0.612  34.074 1.00 18.74 ? 12  A   Q "C2'" 1 
ATOM   3292 O "O2'" . A   G 2 12 ? -19.665 0.303   33.463 1.00 23.79 ? 12  A   Q "O2'" 1 
ATOM   3293 C "C1'" . A   G 2 12 ? -17.792 -1.142  33.054 1.00 16.56 ? 12  A   Q "C1'" 1 
ATOM   3294 N N9    . A   G 2 12 ? -18.295 -2.257  32.268 1.00 8.24  ? 12  A   Q N9    1 
ATOM   3295 C C8    . A   G 2 12 ? -18.881 -3.395  32.754 1.00 13.42 ? 12  A   Q C8    1 
ATOM   3296 N N7    . A   G 2 12 ? -19.233 -4.237  31.819 1.00 11.59 ? 12  A   Q N7    1 
ATOM   3297 C C5    . A   G 2 12 ? -18.863 -3.613  30.641 1.00 7.43  ? 12  A   Q C5    1 
ATOM   3298 C C6    . A   G 2 12 ? -18.972 -4.001  29.294 1.00 12.61 ? 12  A   Q C6    1 
ATOM   3299 N N6    . A   G 2 12 ? -19.499 -5.155  28.898 1.00 15.65 ? 12  A   Q N6    1 
ATOM   3300 N N1    . A   G 2 12 ? -18.494 -3.148  28.362 1.00 9.62  ? 12  A   Q N1    1 
ATOM   3301 C C2    . A   G 2 12 ? -17.954 -1.995  28.768 1.00 9.19  ? 12  A   Q C2    1 
ATOM   3302 N N3    . A   G 2 12 ? -17.802 -1.525  30.001 1.00 5.87  ? 12  A   Q N3    1 
ATOM   3303 C C4    . A   G 2 12 ? -18.275 -2.393  30.905 1.00 6.93  ? 12  A   Q C4    1 
ATOM   3304 P P     . A   G 2 13 ? -17.113 2.357   35.806 1.00 24.14 ? 13  A   Q P     1 
ATOM   3305 O OP1   . A   G 2 13 ? -16.667 3.656   35.214 1.00 16.92 ? 13  A   Q OP1   1 
ATOM   3306 O OP2   . A   G 2 13 ? -16.170 1.765   36.808 1.00 31.61 ? 13  A   Q OP2   1 
ATOM   3307 O "O5'" . A   G 2 13 ? -18.508 2.610   36.556 1.00 30.77 ? 13  A   Q "O5'" 1 
ATOM   3308 C "C5'" . A   G 2 13 ? -19.519 3.413   35.906 1.00 20.74 ? 13  A   Q "C5'" 1 
ATOM   3309 C "C4'" . A   G 2 13 ? -20.640 3.688   36.874 1.00 15.36 ? 13  A   Q "C4'" 1 
ATOM   3310 O "O4'" . A   G 2 13 ? -20.102 4.124   38.151 1.00 25.78 ? 13  A   Q "O4'" 1 
ATOM   3311 C "C3'" . A   G 2 13 ? -21.613 4.792   36.452 1.00 23.73 ? 13  A   Q "C3'" 1 
ATOM   3312 O "O3'" . A   G 2 13 ? -22.917 4.475   36.919 1.00 22.59 ? 13  A   Q "O3'" 1 
ATOM   3313 C "C2'" . A   G 2 13 ? -21.006 6.007   37.148 1.00 32.19 ? 13  A   Q "C2'" 1 
ATOM   3314 O "O2'" . A   G 2 13 ? -21.892 7.097   37.268 1.00 25.95 ? 13  A   Q "O2'" 1 
ATOM   3315 C "C1'" . A   G 2 13 ? -20.673 5.367   38.490 1.00 27.93 ? 13  A   Q "C1'" 1 
ATOM   3316 N N9    . A   G 2 13 ? -19.739 6.140   39.298 1.00 22.06 ? 13  A   Q N9    1 
ATOM   3317 C C8    . A   G 2 13 ? -18.479 6.536   38.938 1.00 27.85 ? 13  A   Q C8    1 
ATOM   3318 N N7    . A   G 2 13 ? -17.872 7.238   39.859 1.00 34.88 ? 13  A   Q N7    1 
ATOM   3319 C C5    . A   G 2 13 ? -18.790 7.316   40.894 1.00 30.22 ? 13  A   Q C5    1 
ATOM   3320 C C6    . A   G 2 13 ? -18.737 7.924   42.163 1.00 35.66 ? 13  A   Q C6    1 
ATOM   3321 N N6    . A   G 2 13 ? -17.684 8.597   42.613 1.00 30.50 ? 13  A   Q N6    1 
ATOM   3322 N N1    . A   G 2 13 ? -19.824 7.806   42.959 1.00 29.56 ? 13  A   Q N1    1 
ATOM   3323 C C2    . A   G 2 13 ? -20.878 7.127   42.496 1.00 29.44 ? 13  A   Q C2    1 
ATOM   3324 N N3    . A   G 2 13 ? -21.038 6.511   41.328 1.00 22.69 ? 13  A   Q N3    1 
ATOM   3325 C C4    . A   G 2 13 ? -19.947 6.644   40.560 1.00 21.91 ? 13  A   Q C4    1 
ATOM   3326 P P     . A   G 2 14 ? -23.875 3.984   35.734 1.00 27.87 ? 14  A   Q P     1 
ATOM   3327 O OP1   . A   G 2 14 ? -25.088 3.291   36.275 1.00 36.41 ? 14  A   Q OP1   1 
ATOM   3328 O OP2   . A   G 2 14 ? -23.113 3.196   34.731 1.00 8.80  ? 14  A   Q OP2   1 
ATOM   3329 O "O5'" . A   G 2 14 ? -24.359 5.362   35.068 1.00 34.98 ? 14  A   Q "O5'" 1 
ATOM   3330 C "C5'" . A   G 2 14 ? -25.406 5.334   34.077 1.00 28.14 ? 14  A   Q "C5'" 1 
ATOM   3331 C "C4'" . A   G 2 14 ? -25.929 6.732   33.870 1.00 26.34 ? 14  A   Q "C4'" 1 
ATOM   3332 O "O4'" . A   G 2 14 ? -26.643 6.784   32.610 1.00 16.45 ? 14  A   Q "O4'" 1 
ATOM   3333 C "C3'" . A   G 2 14 ? -26.929 7.232   34.918 1.00 19.60 ? 14  A   Q "C3'" 1 
ATOM   3334 O "O3'" . A   G 2 14 ? -26.898 8.648   35.032 1.00 23.96 ? 14  A   Q "O3'" 1 
ATOM   3335 C "C2'" . A   G 2 14 ? -28.242 6.747   34.308 1.00 28.64 ? 14  A   Q "C2'" 1 
ATOM   3336 O "O2'" . A   G 2 14 ? -29.403 7.414   34.747 1.00 20.66 ? 14  A   Q "O2'" 1 
ATOM   3337 C "C1'" . A   G 2 14 ? -27.991 7.097   32.851 1.00 23.73 ? 14  A   Q "C1'" 1 
ATOM   3338 N N9    . A   G 2 14 ? -28.833 6.351   31.931 1.00 31.90 ? 14  A   Q N9    1 
ATOM   3339 C C8    . A   G 2 14 ? -28.939 4.992   31.808 1.00 21.42 ? 14  A   Q C8    1 
ATOM   3340 N N7    . A   G 2 14 ? -29.788 4.622   30.885 1.00 24.55 ? 14  A   Q N7    1 
ATOM   3341 C C5    . A   G 2 14 ? -30.276 5.812   30.369 1.00 31.76 ? 14  A   Q C5    1 
ATOM   3342 C C6    . A   G 2 14 ? -31.218 6.103   29.363 1.00 42.96 ? 14  A   Q C6    1 
ATOM   3343 N N6    . A   G 2 14 ? -31.858 5.184   28.648 1.00 46.07 ? 14  A   Q N6    1 
ATOM   3344 N N1    . A   G 2 14 ? -31.475 7.407   29.109 1.00 34.99 ? 14  A   Q N1    1 
ATOM   3345 C C2    . A   G 2 14 ? -30.830 8.336   29.817 1.00 23.53 ? 14  A   Q C2    1 
ATOM   3346 N N3    . A   G 2 14 ? -29.933 8.183   30.780 1.00 31.75 ? 14  A   Q N3    1 
ATOM   3347 C C4    . A   G 2 14 ? -29.695 6.885   31.011 1.00 27.60 ? 14  A   Q C4    1 
ATOM   3348 P P     . A   G 2 15 ? -26.721 9.337   36.472 1.00 14.30 ? 15  A   Q P     1 
ATOM   3349 O OP1   . A   G 2 15 ? -26.549 8.304   37.526 1.00 7.99  ? 15  A   Q OP1   1 
ATOM   3350 O OP2   . A   G 2 15 ? -27.765 10.378  36.643 1.00 23.29 ? 15  A   Q OP2   1 
ATOM   3351 O "O5'" . A   G 2 15 ? -25.329 10.088  36.294 1.00 35.21 ? 15  A   Q "O5'" 1 
ATOM   3352 C "C5'" . A   G 2 15 ? -24.104 9.363   36.306 1.00 11.89 ? 15  A   Q "C5'" 1 
ATOM   3353 C "C4'" . A   G 2 15 ? -23.188 9.786   35.184 1.00 13.23 ? 15  A   Q "C4'" 1 
ATOM   3354 O "O4'" . A   G 2 15 ? -23.786 9.416   33.910 1.00 14.97 ? 15  A   Q "O4'" 1 
ATOM   3355 C "C3'" . A   G 2 15 ? -22.904 11.285  35.101 1.00 19.65 ? 15  A   Q "C3'" 1 
ATOM   3356 O "O3'" . A   G 2 15 ? -21.563 11.498  34.663 1.00 24.96 ? 15  A   Q "O3'" 1 
ATOM   3357 C "C2'" . A   G 2 15 ? -23.883 11.757  34.031 1.00 24.45 ? 15  A   Q "C2'" 1 
ATOM   3358 O "O2'" . A   G 2 15 ? -23.509 12.945  33.366 1.00 28.73 ? 15  A   Q "O2'" 1 
ATOM   3359 C "C1'" . A   G 2 15 ? -23.899 10.559  33.086 1.00 16.37 ? 15  A   Q "C1'" 1 
ATOM   3360 N N9    . A   G 2 15 ? -25.123 10.441  32.289 1.00 24.52 ? 15  A   Q N9    1 
ATOM   3361 C C8    . A   G 2 15 ? -26.422 10.417  32.732 1.00 12.32 ? 15  A   Q C8    1 
ATOM   3362 N N7    . A   G 2 15 ? -27.305 10.304  31.771 1.00 15.09 ? 15  A   Q N7    1 
ATOM   3363 C C5    . A   G 2 15 ? -26.536 10.250  30.617 1.00 10.52 ? 15  A   Q C5    1 
ATOM   3364 C C6    . A   G 2 15 ? -26.876 10.131  29.258 1.00 10.00 ? 15  A   Q C6    1 
ATOM   3365 N N6    . A   G 2 15 ? -28.133 10.039  28.816 1.00 15.87 ? 15  A   Q N6    1 
ATOM   3366 N N1    . A   G 2 15 ? -25.869 10.108  28.357 1.00 8.12  ? 15  A   Q N1    1 
ATOM   3367 C C2    . A   G 2 15 ? -24.610 10.197  28.803 1.00 8.99  ? 15  A   Q C2    1 
ATOM   3368 N N3    . A   G 2 15 ? -24.165 10.314  30.052 1.00 13.03 ? 15  A   Q N3    1 
ATOM   3369 C C4    . A   G 2 15 ? -25.190 10.331  30.921 1.00 21.78 ? 15  A   Q C4    1 
ATOM   3370 P P     . A   G 2 16 ? -20.394 11.736  35.738 1.00 19.22 ? 16  A   Q P     1 
ATOM   3371 O OP1   . A   G 2 16 ? -19.135 12.001  34.998 1.00 20.71 ? 16  A   Q OP1   1 
ATOM   3372 O OP2   . A   G 2 16 ? -20.446 10.628  36.727 1.00 21.43 ? 16  A   Q OP2   1 
ATOM   3373 O "O5'" . A   G 2 16 ? -20.823 13.080  36.476 1.00 25.56 ? 16  A   Q "O5'" 1 
ATOM   3374 C "C5'" . A   G 2 16 ? -20.701 14.341  35.825 1.00 12.99 ? 16  A   Q "C5'" 1 
ATOM   3375 C "C4'" . A   G 2 16 ? -21.074 15.480  36.741 1.00 22.48 ? 16  A   Q "C4'" 1 
ATOM   3376 O "O4'" . A   G 2 16 ? -20.464 15.262  38.044 1.00 16.54 ? 16  A   Q "O4'" 1 
ATOM   3377 C "C3'" . A   G 2 16 ? -20.608 16.859  36.282 1.00 20.41 ? 16  A   Q "C3'" 1 
ATOM   3378 O "O3'" . A   G 2 16 ? -21.547 17.846  36.704 1.00 26.65 ? 16  A   Q "O3'" 1 
ATOM   3379 C "C2'" . A   G 2 16 ? -19.297 17.035  37.041 1.00 27.28 ? 16  A   Q "C2'" 1 
ATOM   3380 O "O2'" . A   G 2 16 ? -18.890 18.375  37.219 1.00 22.98 ? 16  A   Q "O2'" 1 
ATOM   3381 C "C1'" . A   G 2 16 ? -19.629 16.359  38.367 1.00 28.82 ? 16  A   Q "C1'" 1 
ATOM   3382 N N9    . A   G 2 16 ? -18.468 15.857  39.105 1.00 31.94 ? 16  A   Q N9    1 
ATOM   3383 C C8    . A   G 2 16 ? -17.557 14.904  38.723 1.00 32.67 ? 16  A   Q C8    1 
ATOM   3384 N N7    . A   G 2 16 ? -16.631 14.671  39.623 1.00 36.33 ? 16  A   Q N7    1 
ATOM   3385 C C5    . A   G 2 16 ? -16.960 15.524  40.668 1.00 38.83 ? 16  A   Q C5    1 
ATOM   3386 C C6    . A   G 2 16 ? -16.373 15.762  41.923 1.00 41.58 ? 16  A   Q C6    1 
ATOM   3387 N N6    . A   G 2 16 ? -15.279 15.133  42.359 1.00 49.81 ? 16  A   Q N6    1 
ATOM   3388 N N1    . A   G 2 16 ? -16.953 16.681  42.726 1.00 35.99 ? 16  A   Q N1    1 
ATOM   3389 C C2    . A   G 2 16 ? -18.050 17.313  42.290 1.00 30.96 ? 16  A   Q C2    1 
ATOM   3390 N N3    . A   G 2 16 ? -18.694 17.177  41.135 1.00 28.54 ? 16  A   Q N3    1 
ATOM   3391 C C4    . A   G 2 16 ? -18.092 16.256  40.362 1.00 36.40 ? 16  A   Q C4    1 
ATOM   3392 P P     . A   G 2 17 ? -22.490 18.577  35.630 1.00 27.67 ? 17  A   Q P     1 
ATOM   3393 O OP1   . A   G 2 17 ? -23.684 19.087  36.351 1.00 28.60 ? 17  A   Q OP1   1 
ATOM   3394 O OP2   . A   G 2 17 ? -22.662 17.670  34.466 1.00 12.38 ? 17  A   Q OP2   1 
ATOM   3395 O "O5'" . A   G 2 17 ? -21.627 19.829  35.155 1.00 28.74 ? 17  A   Q "O5'" 1 
ATOM   3396 C "C5'" . A   G 2 17 ? -21.897 20.479  33.918 1.00 30.67 ? 17  A   Q "C5'" 1 
ATOM   3397 C "C4'" . A   G 2 17 ? -21.104 21.755  33.781 1.00 22.62 ? 17  A   Q "C4'" 1 
ATOM   3398 O "O4'" . A   G 2 17 ? -21.448 22.401  32.524 1.00 21.86 ? 17  A   Q "O4'" 1 
ATOM   3399 C "C3'" . A   G 2 17 ? -21.362 22.794  34.872 1.00 30.90 ? 17  A   Q "C3'" 1 
ATOM   3400 O "O3'" . A   G 2 17 ? -20.171 23.538  35.116 1.00 37.39 ? 17  A   Q "O3'" 1 
ATOM   3401 C "C2'" . A   G 2 17 ? -22.401 23.701  34.227 1.00 29.77 ? 17  A   Q "C2'" 1 
ATOM   3402 O "O2'" . A   G 2 17 ? -22.461 25.004  34.768 1.00 31.60 ? 17  A   Q "O2'" 1 
ATOM   3403 C "C1'" . A   G 2 17 ? -21.926 23.709  32.778 1.00 25.71 ? 17  A   Q "C1'" 1 
ATOM   3404 N N9    . A   G 2 17 ? -22.966 24.027  31.801 1.00 35.36 ? 17  A   Q N9    1 
ATOM   3405 C C8    . A   G 2 17 ? -24.105 23.323  31.504 1.00 23.84 ? 17  A   Q C8    1 
ATOM   3406 N N7    . A   G 2 17 ? -24.835 23.878  30.567 1.00 26.65 ? 17  A   Q N7    1 
ATOM   3407 C C5    . A   G 2 17 ? -24.126 25.022  30.227 1.00 29.71 ? 17  A   Q C5    1 
ATOM   3408 C C6    . A   G 2 17 ? -24.366 26.048  29.296 1.00 16.48 ? 17  A   Q C6    1 
ATOM   3409 N N6    . A   G 2 17 ? -25.434 26.088  28.498 1.00 23.41 ? 17  A   Q N6    1 
ATOM   3410 N N1    . A   G 2 17 ? -23.456 27.044  29.208 1.00 34.16 ? 17  A   Q N1    1 
ATOM   3411 C C2    . A   G 2 17 ? -22.382 27.005  30.007 1.00 30.17 ? 17  A   Q C2    1 
ATOM   3412 N N3    . A   G 2 17 ? -22.048 26.098  30.920 1.00 22.09 ? 17  A   Q N3    1 
ATOM   3413 C C4    . A   G 2 17 ? -22.971 25.123  30.978 1.00 31.08 ? 17  A   Q C4    1 
ATOM   3414 P P     . A   G 2 18 ? -19.444 23.468  36.545 1.00 19.71 ? 18  A   Q P     1 
ATOM   3415 O OP1   . A   G 2 18 ? -20.061 22.683  37.637 1.00 18.12 ? 18  A   Q OP1   1 
ATOM   3416 O OP2   . A   G 2 18 ? -19.272 24.870  37.004 1.00 36.89 ? 18  A   Q OP2   1 
ATOM   3417 O "O5'" . A   G 2 18 ? -18.027 22.851  36.196 1.00 18.07 ? 18  A   Q "O5'" 1 
ATOM   3418 C "C5'" . A   G 2 18 ? -17.746 21.455  36.256 1.00 19.16 ? 18  A   Q "C5'" 1 
ATOM   3419 C "C4'" . A   G 2 18 ? -16.839 21.084  35.114 1.00 28.86 ? 18  A   Q "C4'" 1 
ATOM   3420 O "O4'" . A   G 2 18 ? -17.586 20.973  33.876 1.00 8.49  ? 18  A   Q "O4'" 1 
ATOM   3421 C "C3'" . A   G 2 18 ? -15.733 22.087  34.810 1.00 35.90 ? 18  A   Q "C3'" 1 
ATOM   3422 O "O3'" . A   G 2 18 ? -14.634 21.973  35.692 1.00 37.87 ? 18  A   Q "O3'" 1 
ATOM   3423 C "C2'" . A   G 2 18 ? -15.400 21.762  33.356 1.00 25.05 ? 18  A   Q "C2'" 1 
ATOM   3424 O "O2'" . A   G 2 18 ? -14.539 20.634  33.277 1.00 43.73 ? 18  A   Q "O2'" 1 
ATOM   3425 C "C1'" . A   G 2 18 ? -16.776 21.385  32.791 1.00 28.68 ? 18  A   Q "C1'" 1 
ATOM   3426 N N9    . A   G 2 18 ? -17.454 22.468  32.046 1.00 21.16 ? 18  A   Q N9    1 
ATOM   3427 C C8    . A   G 2 18 ? -18.062 23.609  32.510 1.00 16.54 ? 18  A   Q C8    1 
ATOM   3428 N N7    . A   G 2 18 ? -18.580 24.353  31.560 1.00 6.31  ? 18  A   Q N7    1 
ATOM   3429 C C5    . A   G 2 18 ? -18.299 23.650  30.395 1.00 18.66 ? 18  A   Q C5    1 
ATOM   3430 C C6    . A   G 2 18 ? -18.577 23.897  29.038 1.00 15.77 ? 18  A   Q C6    1 
ATOM   3431 N N6    . A   G 2 18 ? -19.234 24.972  28.599 1.00 19.86 ? 18  A   Q N6    1 
ATOM   3432 N N1    . A   G 2 18 ? -18.153 22.989  28.130 1.00 19.97 ? 18  A   Q N1    1 
ATOM   3433 C C2    . A   G 2 18 ? -17.495 21.907  28.562 1.00 13.19 ? 18  A   Q C2    1 
ATOM   3434 N N3    . A   G 2 18 ? -17.175 21.565  29.806 1.00 12.44 ? 18  A   Q N3    1 
ATOM   3435 C C4    . A   G 2 18 ? -17.611 22.487  30.683 1.00 16.17 ? 18  A   Q C4    1 
HETATM 3436 O O     . HOH H 3 .  ? -7.825  3.255   14.981 1.00 13.60 ? 201 HOH A O     1 
HETATM 3437 O O     . HOH H 3 .  ? 13.606  6.123   28.600 1.00 10.73 ? 202 HOH A O     1 
HETATM 3438 O O     . HOH H 3 .  ? 6.695   6.711   33.877 1.00 37.00 ? 203 HOH A O     1 
HETATM 3439 O O     . HOH H 3 .  ? 3.555   -7.680  25.334 1.00 15.49 ? 204 HOH A O     1 
HETATM 3440 O O     . HOH H 3 .  ? -3.888  -2.958  10.691 1.00 15.40 ? 205 HOH A O     1 
HETATM 3441 O O     . HOH H 3 .  ? -2.941  1.810   22.626 1.00 21.11 ? 206 HOH A O     1 
HETATM 3442 O O     . HOH H 3 .  ? -7.615  4.009   32.449 1.00 11.06 ? 207 HOH A O     1 
HETATM 3443 O O     . HOH H 3 .  ? 11.325  -7.947  13.585 1.00 30.79 ? 208 HOH A O     1 
HETATM 3444 O O     . HOH H 3 .  ? 2.655   6.822   11.599 1.00 36.85 ? 209 HOH A O     1 
HETATM 3445 O O     . HOH H 3 .  ? -3.802  8.957   32.854 1.00 20.36 ? 210 HOH A O     1 
HETATM 3446 O O     . HOH H 3 .  ? -0.059  9.104   28.636 1.00 8.10  ? 211 HOH A O     1 
HETATM 3447 O O     . HOH H 3 .  ? 5.151   6.497   9.518  1.00 35.55 ? 212 HOH A O     1 
HETATM 3448 O O     . HOH H 3 .  ? -4.784  2.717   15.833 1.00 9.13  ? 213 HOH A O     1 
HETATM 3449 O O     . HOH H 3 .  ? -1.237  -1.710  8.419  1.00 41.55 ? 214 HOH A O     1 
HETATM 3450 O O     . HOH H 3 .  ? 19.418  -4.085  23.614 1.00 39.53 ? 215 HOH A O     1 
HETATM 3451 O O     . HOH H 3 .  ? 10.903  -1.811  29.839 1.00 44.16 ? 216 HOH A O     1 
HETATM 3452 O O     . HOH H 3 .  ? 13.652  -6.020  26.289 1.00 34.92 ? 217 HOH A O     1 
HETATM 3453 O O     . HOH H 3 .  ? 12.301  -6.459  19.918 1.00 21.88 ? 218 HOH A O     1 
HETATM 3454 O O     . HOH H 3 .  ? 11.822  -2.979  21.017 1.00 13.96 ? 219 HOH A O     1 
HETATM 3455 O O     . HOH H 3 .  ? 11.050  3.304   28.606 1.00 19.00 ? 220 HOH A O     1 
HETATM 3456 O O     . HOH H 3 .  ? -7.724  9.362   29.256 1.00 26.53 ? 221 HOH A O     1 
HETATM 3457 O O     . HOH H 3 .  ? -4.888  5.584   34.931 1.00 20.17 ? 222 HOH A O     1 
HETATM 3458 O O     . HOH H 3 .  ? 6.576   -5.573  32.008 1.00 19.77 ? 223 HOH A O     1 
HETATM 3459 O O     . HOH H 3 .  ? -4.976  5.296   15.300 1.00 26.21 ? 224 HOH A O     1 
HETATM 3460 O O     . HOH H 3 .  ? -10.136 4.701   16.121 1.00 13.97 ? 225 HOH A O     1 
HETATM 3461 O O     . HOH H 3 .  ? 10.750  -7.897  26.504 1.00 30.12 ? 226 HOH A O     1 
HETATM 3462 O O     . HOH H 3 .  ? 11.690  0.820   30.095 1.00 41.86 ? 227 HOH A O     1 
HETATM 3463 O O     . HOH H 3 .  ? 10.488  -4.382  30.452 1.00 19.30 ? 228 HOH A O     1 
HETATM 3464 O O     . HOH H 3 .  ? -6.553  8.759   17.953 1.00 10.26 ? 229 HOH A O     1 
HETATM 3465 O O     . HOH H 3 .  ? 5.510   4.666   35.900 1.00 19.58 ? 230 HOH A O     1 
HETATM 3466 O O     . HOH H 3 .  ? -8.253  9.739   26.658 1.00 17.21 ? 231 HOH A O     1 
HETATM 3467 O O     . HOH H 3 .  ? 6.456   -10.831 32.346 1.00 30.51 ? 232 HOH A O     1 
HETATM 3468 O O     . HOH H 3 .  ? -1.092  -0.402  4.569  1.00 19.44 ? 233 HOH A O     1 
HETATM 3469 O O     . HOH H 3 .  ? 2.828   7.338   9.314  1.00 14.06 ? 234 HOH A O     1 
HETATM 3470 O O     . HOH H 3 .  ? 1.039   -12.478 16.525 1.00 23.18 ? 235 HOH A O     1 
HETATM 3471 O O     . HOH H 3 .  ? -7.559  9.399   24.483 1.00 15.94 ? 236 HOH A O     1 
HETATM 3472 O O     . HOH I 3 .  ? -18.777 -11.133 24.659 1.00 9.88  ? 201 HOH B O     1 
HETATM 3473 O O     . HOH I 3 .  ? -12.789 -9.172  32.563 1.00 19.01 ? 202 HOH B O     1 
HETATM 3474 O O     . HOH I 3 .  ? -25.311 -13.387 22.601 1.00 28.55 ? 203 HOH B O     1 
HETATM 3475 O O     . HOH I 3 .  ? -14.119 1.353   15.634 1.00 9.70  ? 204 HOH B O     1 
HETATM 3476 O O     . HOH I 3 .  ? -18.439 -3.343  12.661 1.00 28.97 ? 205 HOH B O     1 
HETATM 3477 O O     . HOH I 3 .  ? -4.178  -6.223  9.148  1.00 41.53 ? 206 HOH B O     1 
HETATM 3478 O O     . HOH I 3 .  ? -13.939 -0.707  22.689 1.00 13.93 ? 207 HOH B O     1 
HETATM 3479 O O     . HOH I 3 .  ? -12.470 5.699   21.755 1.00 14.98 ? 208 HOH B O     1 
HETATM 3480 O O     . HOH I 3 .  ? -12.821 -16.925 26.939 1.00 13.15 ? 209 HOH B O     1 
HETATM 3481 O O     . HOH I 3 .  ? -5.878  0.596   28.806 1.00 7.92  ? 210 HOH B O     1 
HETATM 3482 O O     . HOH I 3 .  ? -3.105  -23.605 16.931 1.00 57.67 ? 211 HOH B O     1 
HETATM 3483 O O     . HOH I 3 .  ? -10.039 -18.570 12.084 1.00 18.11 ? 212 HOH B O     1 
HETATM 3484 O O     . HOH I 3 .  ? -14.833 4.284   14.584 1.00 19.74 ? 213 HOH B O     1 
HETATM 3485 O O     . HOH I 3 .  ? -5.275  -12.023 28.794 1.00 44.32 ? 214 HOH B O     1 
HETATM 3486 O O     . HOH I 3 .  ? -9.760  -5.217  9.994  1.00 27.68 ? 215 HOH B O     1 
HETATM 3487 O O     . HOH I 3 .  ? -14.476 4.128   33.038 1.00 19.71 ? 216 HOH B O     1 
HETATM 3488 O O     . HOH I 3 .  ? -11.909 -9.514  8.908  1.00 24.68 ? 217 HOH B O     1 
HETATM 3489 O O     . HOH I 3 .  ? -7.082  -13.780 30.346 1.00 23.80 ? 218 HOH B O     1 
HETATM 3490 O O     . HOH I 3 .  ? -20.745 -18.027 17.685 1.00 27.63 ? 219 HOH B O     1 
HETATM 3491 O O     . HOH I 3 .  ? -9.843  5.684   18.254 1.00 8.55  ? 220 HOH B O     1 
HETATM 3492 O O     . HOH I 3 .  ? -11.830 2.662   34.933 1.00 25.10 ? 221 HOH B O     1 
HETATM 3493 O O     . HOH I 3 .  ? -1.592  -1.827  6.611  1.00 20.77 ? 222 HOH B O     1 
HETATM 3494 O O     . HOH I 3 .  ? -10.131 -15.040 29.964 1.00 18.57 ? 223 HOH B O     1 
HETATM 3495 O O     . HOH I 3 .  ? -22.996 -14.819 17.493 1.00 38.45 ? 224 HOH B O     1 
HETATM 3496 O O     . HOH I 3 .  ? -25.174 -13.743 19.400 1.00 31.41 ? 225 HOH B O     1 
HETATM 3497 O O     . HOH I 3 .  ? -15.125 -12.387 11.006 1.00 30.00 ? 226 HOH B O     1 
HETATM 3498 O O     . HOH I 3 .  ? -13.689 -18.091 19.705 1.00 20.82 ? 227 HOH B O     1 
HETATM 3499 O O     . HOH I 3 .  ? -5.781  -3.828  9.458  1.00 27.30 ? 228 HOH B O     1 
HETATM 3500 O O     . HOH I 3 .  ? -12.401 -12.419 9.892  1.00 30.00 ? 229 HOH B O     1 
HETATM 3501 O O     . HOH I 3 .  ? -9.275  -2.641  9.924  1.00 26.11 ? 230 HOH B O     1 
HETATM 3502 O O     . HOH I 3 .  ? -26.441 -9.616  20.116 1.00 33.76 ? 231 HOH B O     1 
HETATM 3503 O O     . HOH I 3 .  ? -10.464 2.636   15.132 1.00 42.58 ? 232 HOH B O     1 
HETATM 3504 O O     . HOH I 3 .  ? -9.896  6.276   32.033 1.00 8.77  ? 233 HOH B O     1 
HETATM 3505 O O     . HOH I 3 .  ? -17.747 -19.478 25.815 1.00 35.15 ? 234 HOH B O     1 
HETATM 3506 O O     . HOH I 3 .  ? -9.700  5.638   34.882 1.00 15.60 ? 235 HOH B O     1 
HETATM 3507 O O     . HOH I 3 .  ? -0.564  -22.976 16.468 1.00 25.87 ? 236 HOH B O     1 
HETATM 3508 O O     . HOH I 3 .  ? -9.970  7.598   25.445 1.00 18.75 ? 237 HOH B O     1 
HETATM 3509 O O     . HOH I 3 .  ? -16.131 -18.726 21.492 1.00 26.30 ? 238 HOH B O     1 
HETATM 3510 O O     . HOH I 3 .  ? -25.612 -11.332 17.485 1.00 40.80 ? 239 HOH B O     1 
HETATM 3511 O O     . HOH J 3 .  ? 7.617   19.617  26.153 1.00 30.80 ? 201 HOH C O     1 
HETATM 3512 O O     . HOH J 3 .  ? -3.366  22.441  12.436 1.00 24.11 ? 202 HOH C O     1 
HETATM 3513 O O     . HOH J 3 .  ? 3.950   9.548   10.495 1.00 14.18 ? 203 HOH C O     1 
HETATM 3514 O O     . HOH J 3 .  ? -2.101  10.099  27.513 1.00 8.68  ? 204 HOH C O     1 
HETATM 3515 O O     . HOH J 3 .  ? 10.759  21.893  27.996 1.00 37.08 ? 205 HOH C O     1 
HETATM 3516 O O     . HOH J 3 .  ? 14.089  22.760  19.315 1.00 25.20 ? 206 HOH C O     1 
HETATM 3517 O O     . HOH J 3 .  ? 11.626  13.485  25.799 1.00 11.64 ? 207 HOH C O     1 
HETATM 3518 O O     . HOH J 3 .  ? 1.131   23.096  34.217 1.00 31.56 ? 208 HOH C O     1 
HETATM 3519 O O     . HOH J 3 .  ? 16.954  26.012  25.414 1.00 33.69 ? 209 HOH C O     1 
HETATM 3520 O O     . HOH J 3 .  ? 6.064   17.770  34.216 1.00 40.08 ? 210 HOH C O     1 
HETATM 3521 O O     . HOH J 3 .  ? 20.954  11.510  26.862 1.00 32.55 ? 211 HOH C O     1 
HETATM 3522 O O     . HOH J 3 .  ? 19.672  12.962  25.087 1.00 27.95 ? 212 HOH C O     1 
HETATM 3523 O O     . HOH J 3 .  ? -1.503  11.267  15.642 1.00 7.53  ? 213 HOH C O     1 
HETATM 3524 O O     . HOH J 3 .  ? 16.736  8.609   22.386 1.00 22.32 ? 214 HOH C O     1 
HETATM 3525 O O     . HOH J 3 .  ? -3.596  9.532   14.615 1.00 26.03 ? 215 HOH C O     1 
HETATM 3526 O O     . HOH J 3 .  ? 8.575   28.962  12.001 1.00 31.17 ? 216 HOH C O     1 
HETATM 3527 O O     . HOH J 3 .  ? 9.689   22.907  30.294 1.00 22.58 ? 217 HOH C O     1 
HETATM 3528 O O     . HOH J 3 .  ? 10.576  18.108  11.735 1.00 15.86 ? 218 HOH C O     1 
HETATM 3529 O O     . HOH J 3 .  ? 2.770   26.090  30.779 1.00 10.14 ? 219 HOH C O     1 
HETATM 3530 O O     . HOH J 3 .  ? -1.649  21.780  9.749  1.00 21.89 ? 220 HOH C O     1 
HETATM 3531 O O     . HOH J 3 .  ? -7.957  13.088  19.256 1.00 8.58  ? 221 HOH C O     1 
HETATM 3532 O O     . HOH J 3 .  ? 16.515  20.240  15.900 1.00 20.46 ? 222 HOH C O     1 
HETATM 3533 O O     . HOH J 3 .  ? -3.610  12.544  35.334 1.00 25.90 ? 223 HOH C O     1 
HETATM 3534 O O     . HOH J 3 .  ? -3.228  17.269  12.032 1.00 16.02 ? 224 HOH C O     1 
HETATM 3535 O O     . HOH J 3 .  ? 11.267  16.573  32.692 1.00 17.53 ? 225 HOH C O     1 
HETATM 3536 O O     . HOH J 3 .  ? -2.488  15.898  13.852 1.00 18.67 ? 226 HOH C O     1 
HETATM 3537 O O     . HOH J 3 .  ? 20.555  8.840   28.231 1.00 25.87 ? 227 HOH C O     1 
HETATM 3538 O O     . HOH J 3 .  ? -8.788  11.971  30.446 1.00 24.81 ? 228 HOH C O     1 
HETATM 3539 O O     . HOH J 3 .  ? -8.075  12.620  33.218 1.00 13.98 ? 229 HOH C O     1 
HETATM 3540 O O     . HOH J 3 .  ? 5.136   30.986  15.575 1.00 7.10  ? 230 HOH C O     1 
HETATM 3541 O O     . HOH J 3 .  ? -8.550  11.821  24.927 1.00 32.67 ? 231 HOH C O     1 
HETATM 3542 O O     . HOH K 3 .  ? -38.833 5.514   25.796 1.00 29.11 ? 201 HOH D O     1 
HETATM 3543 O O     . HOH K 3 .  ? -27.817 1.869   32.321 1.00 22.72 ? 202 HOH D O     1 
HETATM 3544 O O     . HOH K 3 .  ? -41.795 -2.043  18.280 1.00 46.60 ? 203 HOH D O     1 
HETATM 3545 O O     . HOH K 3 .  ? -17.725 -8.111  12.433 1.00 18.32 ? 204 HOH D O     1 
HETATM 3546 O O     . HOH K 3 .  ? -17.853 10.856  14.912 1.00 9.54  ? 205 HOH D O     1 
HETATM 3547 O O     . HOH K 3 .  ? -22.579 -3.884  34.166 1.00 32.74 ? 206 HOH D O     1 
HETATM 3548 O O     . HOH K 3 .  ? -27.136 -5.968  27.841 1.00 29.68 ? 207 HOH D O     1 
HETATM 3549 O O     . HOH K 3 .  ? -26.062 10.105  12.766 1.00 22.04 ? 208 HOH D O     1 
HETATM 3550 O O     . HOH K 3 .  ? -34.103 6.196   31.626 1.00 36.11 ? 209 HOH D O     1 
HETATM 3551 O O     . HOH K 3 .  ? -25.698 10.681  10.779 1.00 15.52 ? 210 HOH D O     1 
HETATM 3552 O O     . HOH K 3 .  ? -19.746 8.417   15.679 1.00 12.60 ? 211 HOH D O     1 
HETATM 3553 O O     . HOH K 3 .  ? -38.666 -0.084  16.523 1.00 20.27 ? 212 HOH D O     1 
HETATM 3554 O O     . HOH K 3 .  ? -13.790 7.276   18.885 1.00 3.81  ? 213 HOH D O     1 
HETATM 3555 O O     . HOH K 3 .  ? -12.905 8.002   29.065 1.00 15.71 ? 214 HOH D O     1 
HETATM 3556 O O     . HOH K 3 .  ? -16.907 7.465   35.049 1.00 21.88 ? 215 HOH D O     1 
HETATM 3557 O O     . HOH K 3 .  ? -31.724 1.421   11.285 1.00 24.04 ? 216 HOH D O     1 
HETATM 3558 O O     . HOH K 3 .  ? -17.790 7.261   4.798  1.00 13.11 ? 217 HOH D O     1 
HETATM 3559 O O     . HOH K 3 .  ? -16.554 1.117   29.011 1.00 10.17 ? 218 HOH D O     1 
HETATM 3560 O O     . HOH K 3 .  ? -41.937 6.044   24.898 1.00 22.57 ? 219 HOH D O     1 
HETATM 3561 O O     . HOH K 3 .  ? -38.112 11.116  21.586 1.00 17.37 ? 220 HOH D O     1 
HETATM 3562 O O     . HOH K 3 .  ? -28.914 -5.349  29.830 1.00 22.17 ? 221 HOH D O     1 
HETATM 3563 O O     . HOH K 3 .  ? -33.127 6.299   25.935 1.00 29.83 ? 222 HOH D O     1 
HETATM 3564 O O     . HOH K 3 .  ? -32.736 3.521   32.759 1.00 22.26 ? 223 HOH D O     1 
HETATM 3565 O O     . HOH K 3 .  ? -18.132 4.658   9.582  1.00 24.86 ? 224 HOH D O     1 
HETATM 3566 O O     . HOH K 3 .  ? -22.152 -1.960  34.170 1.00 47.18 ? 225 HOH D O     1 
HETATM 3567 O O     . HOH K 3 .  ? -25.306 0.208   35.295 1.00 25.24 ? 226 HOH D O     1 
HETATM 3568 O O     . HOH K 3 .  ? -31.465 -0.207  9.329  1.00 20.76 ? 227 HOH D O     1 
HETATM 3569 O O     . HOH K 3 .  ? -14.912 11.256  17.711 1.00 8.28  ? 228 HOH D O     1 
HETATM 3570 O O     . HOH K 3 .  ? -13.386 6.872   32.831 1.00 9.12  ? 229 HOH D O     1 
HETATM 3571 O O     . HOH K 3 .  ? -16.953 6.943   15.078 1.00 44.19 ? 230 HOH D O     1 
HETATM 3572 O O     . HOH K 3 .  ? -23.125 -1.418  35.709 1.00 21.61 ? 231 HOH D O     1 
HETATM 3573 O O     . HOH K 3 .  ? -36.022 10.738  17.172 1.00 20.97 ? 232 HOH D O     1 
HETATM 3574 O O     . HOH K 3 .  ? -42.951 8.837   24.827 1.00 25.06 ? 233 HOH D O     1 
HETATM 3575 O O     . HOH K 3 .  ? -36.113 3.066   34.273 1.00 23.05 ? 234 HOH D O     1 
HETATM 3576 O O     . HOH K 3 .  ? -41.909 0.785   17.562 1.00 22.24 ? 235 HOH D O     1 
HETATM 3577 O O     . HOH K 3 .  ? -40.952 1.472   27.243 1.00 17.00 ? 236 HOH D O     1 
HETATM 3578 O O     . HOH K 3 .  ? -12.964 7.382   35.685 1.00 20.72 ? 237 HOH D O     1 
HETATM 3579 O O     . HOH K 3 .  ? -10.684 9.644   31.029 1.00 26.81 ? 238 HOH D O     1 
HETATM 3580 O O     . HOH L 3 .  ? -17.025 26.407  9.537  1.00 24.57 ? 201 HOH E O     1 
HETATM 3581 O O     . HOH L 3 .  ? -15.265 17.913  27.257 1.00 15.22 ? 202 HOH E O     1 
HETATM 3582 O O     . HOH L 3 .  ? -10.506 25.614  10.793 1.00 43.49 ? 203 HOH E O     1 
HETATM 3583 O O     . HOH L 3 .  ? -7.030  15.558  33.088 1.00 11.84 ? 204 HOH E O     1 
HETATM 3584 O O     . HOH L 3 .  ? -7.340  18.589  15.403 1.00 9.13  ? 205 HOH E O     1 
HETATM 3585 O O     . HOH L 3 .  ? -5.909  15.625  14.810 1.00 10.07 ? 206 HOH E O     1 
HETATM 3586 O O     . HOH L 3 .  ? -15.884 26.739  34.454 1.00 16.57 ? 207 HOH E O     1 
HETATM 3587 O O     . HOH L 3 .  ? -12.982 32.527  28.971 1.00 53.14 ? 208 HOH E O     1 
HETATM 3588 O O     . HOH L 3 .  ? -10.540 17.144  34.986 1.00 13.56 ? 209 HOH E O     1 
HETATM 3589 O O     . HOH L 3 .  ? -5.834  42.781  19.677 1.00 32.21 ? 210 HOH E O     1 
HETATM 3590 O O     . HOH L 3 .  ? -12.676 25.878  6.519  1.00 24.28 ? 211 HOH E O     1 
HETATM 3591 O O     . HOH L 3 .  ? -10.393 17.273  15.588 1.00 10.15 ? 212 HOH E O     1 
HETATM 3592 O O     . HOH L 3 .  ? -18.077 35.916  11.686 1.00 24.20 ? 213 HOH E O     1 
HETATM 3593 O O     . HOH L 3 .  ? 1.406   36.369  18.642 1.00 45.21 ? 214 HOH E O     1 
HETATM 3594 O O     . HOH L 3 .  ? -11.659 12.712  29.132 1.00 17.69 ? 215 HOH E O     1 
HETATM 3595 O O     . HOH L 3 .  ? -7.381  30.255  8.516  1.00 32.95 ? 216 HOH E O     1 
HETATM 3596 O O     . HOH L 3 .  ? 4.167   33.271  22.060 1.00 21.28 ? 217 HOH E O     1 
HETATM 3597 O O     . HOH L 3 .  ? -13.604 24.394  10.569 1.00 17.18 ? 218 HOH E O     1 
HETATM 3598 O O     . HOH L 3 .  ? -7.359  13.183  16.777 1.00 5.74  ? 219 HOH E O     1 
HETATM 3599 O O     . HOH L 3 .  ? 1.260   38.911  25.163 1.00 26.56 ? 220 HOH E O     1 
HETATM 3600 O O     . HOH L 3 .  ? -7.742  32.250  10.862 1.00 32.79 ? 221 HOH E O     1 
HETATM 3601 O O     . HOH L 3 .  ? -12.329 35.340  33.908 1.00 8.31  ? 222 HOH E O     1 
HETATM 3602 O O     . HOH L 3 .  ? 1.903   33.895  18.006 1.00 32.55 ? 223 HOH E O     1 
HETATM 3603 O O     . HOH L 3 .  ? -16.803 31.646  33.826 1.00 13.44 ? 224 HOH E O     1 
HETATM 3604 O O     . HOH L 3 .  ? -8.460  17.064  34.708 1.00 22.05 ? 225 HOH E O     1 
HETATM 3605 O O     . HOH L 3 .  ? -11.527 24.241  9.226  1.00 24.72 ? 226 HOH E O     1 
HETATM 3606 O O     . HOH L 3 .  ? -11.652 13.618  31.571 1.00 10.08 ? 227 HOH E O     1 
HETATM 3607 O O     . HOH L 3 .  ? -9.682  14.501  34.590 1.00 14.53 ? 228 HOH E O     1 
HETATM 3608 O O     . HOH L 3 .  ? -2.911  41.707  16.271 1.00 21.48 ? 229 HOH E O     1 
HETATM 3609 O O     . HOH L 3 .  ? -15.290 24.160  9.478  1.00 24.68 ? 230 HOH E O     1 
HETATM 3610 O O     . HOH L 3 .  ? -11.467 22.534  7.245  1.00 28.70 ? 231 HOH E O     1 
HETATM 3611 O O     . HOH L 3 .  ? -11.772 13.468  33.877 1.00 9.83  ? 232 HOH E O     1 
HETATM 3612 O O     . HOH L 3 .  ? -13.017 20.625  6.343  1.00 23.14 ? 233 HOH E O     1 
HETATM 3613 O O     . HOH L 3 .  ? 3.832   31.805  17.870 1.00 14.64 ? 234 HOH E O     1 
HETATM 3614 O O     . HOH L 3 .  ? -18.594 45.299  28.052 1.00 20.46 ? 235 HOH E O     1 
HETATM 3615 O O     . HOH L 3 .  ? -9.400  16.761  13.478 1.00 9.88  ? 236 HOH E O     1 
HETATM 3616 O O     . HOH L 3 .  ? -18.976 31.090  34.976 1.00 37.10 ? 237 HOH E O     1 
HETATM 3617 O O     . HOH L 3 .  ? -16.736 22.195  3.220  1.00 22.91 ? 238 HOH E O     1 
HETATM 3618 O O     . HOH L 3 .  ? -15.441 37.954  34.851 1.00 21.30 ? 239 HOH E O     1 
HETATM 3619 O O     . HOH L 3 .  ? -16.725 35.882  36.105 1.00 35.16 ? 240 HOH E O     1 
HETATM 3620 O O     . HOH L 3 .  ? -19.397 35.468  36.930 1.00 18.12 ? 241 HOH E O     1 
HETATM 3621 O O     . HOH M 3 .  ? -28.615 30.206  31.554 1.00 28.79 ? 201 HOH F O     1 
HETATM 3622 O O     . HOH M 3 .  ? -17.273 22.876  10.382 1.00 14.80 ? 202 HOH F O     1 
HETATM 3623 O O     . HOH M 3 .  ? -13.749 16.628  14.754 1.00 12.54 ? 203 HOH F O     1 
HETATM 3624 O O     . HOH M 3 .  ? -25.751 37.143  29.237 1.00 25.57 ? 204 HOH F O     1 
HETATM 3625 O O     . HOH M 3 .  ? -25.365 22.057  8.574  1.00 16.41 ? 205 HOH F O     1 
HETATM 3626 O O     . HOH M 3 .  ? -14.236 11.119  20.523 1.00 14.75 ? 206 HOH F O     1 
HETATM 3627 O O     . HOH M 3 .  ? -37.903 27.206  12.163 1.00 22.24 ? 207 HOH F O     1 
HETATM 3628 O O     . HOH M 3 .  ? -38.977 19.367  28.974 1.00 28.71 ? 208 HOH F O     1 
HETATM 3629 O O     . HOH M 3 .  ? -28.435 16.723  36.325 1.00 47.96 ? 209 HOH F O     1 
HETATM 3630 O O     . HOH M 3 .  ? -16.548 16.942  15.537 1.00 15.98 ? 210 HOH F O     1 
HETATM 3631 O O     . HOH M 3 .  ? -13.619 16.116  32.617 1.00 11.29 ? 211 HOH F O     1 
HETATM 3632 O O     . HOH M 3 .  ? -13.361 14.288  21.803 1.00 17.16 ? 212 HOH F O     1 
HETATM 3633 O O     . HOH M 3 .  ? -40.429 24.287  23.211 1.00 19.50 ? 213 HOH F O     1 
HETATM 3634 O O     . HOH M 3 .  ? -32.376 16.028  28.104 1.00 14.09 ? 214 HOH F O     1 
HETATM 3635 O O     . HOH M 3 .  ? -15.464 14.693  34.240 1.00 49.74 ? 215 HOH F O     1 
HETATM 3636 O O     . HOH M 3 .  ? -32.083 20.698  29.752 1.00 30.03 ? 216 HOH F O     1 
HETATM 3637 O O     . HOH M 3 .  ? -20.812 10.499  28.705 1.00 9.68  ? 217 HOH F O     1 
HETATM 3638 O O     . HOH M 3 .  ? -13.698 10.437  28.947 1.00 7.99  ? 218 HOH F O     1 
HETATM 3639 O O     . HOH M 3 .  ? -33.087 31.176  18.889 1.00 20.27 ? 219 HOH F O     1 
HETATM 3640 O O     . HOH M 3 .  ? -35.284 23.262  12.405 1.00 40.40 ? 220 HOH F O     1 
HETATM 3641 O O     . HOH M 3 .  ? -42.273 12.371  20.875 1.00 40.57 ? 221 HOH F O     1 
HETATM 3642 O O     . HOH M 3 .  ? -17.772 10.353  32.727 1.00 15.53 ? 222 HOH F O     1 
HETATM 3643 O O     . HOH M 3 .  ? -33.619 26.764  19.067 1.00 16.43 ? 223 HOH F O     1 
HETATM 3644 O O     . HOH M 3 .  ? -27.567 13.963  34.795 1.00 29.86 ? 224 HOH F O     1 
HETATM 3645 O O     . HOH M 3 .  ? -11.763 14.703  16.508 1.00 14.12 ? 225 HOH F O     1 
HETATM 3646 O O     . HOH M 3 .  ? -26.623 33.234  18.585 1.00 24.09 ? 226 HOH F O     1 
HETATM 3647 O O     . HOH M 3 .  ? -14.475 11.287  32.654 1.00 19.02 ? 227 HOH F O     1 
HETATM 3648 O O     . HOH M 3 .  ? -42.197 19.181  20.732 1.00 30.00 ? 228 HOH F O     1 
HETATM 3649 O O     . HOH M 3 .  ? -16.901 13.311  15.400 1.00 24.08 ? 229 HOH F O     1 
HETATM 3650 O O     . HOH M 3 .  ? -41.774 26.806  12.836 1.00 43.32 ? 230 HOH F O     1 
HETATM 3651 O O     . HOH M 3 .  ? -32.608 28.894  18.821 1.00 20.21 ? 231 HOH F O     1 
HETATM 3652 O O     . HOH M 3 .  ? -33.026 28.123  16.263 1.00 25.46 ? 232 HOH F O     1 
HETATM 3653 O O     . HOH M 3 .  ? -28.462 27.668  10.578 1.00 20.70 ? 233 HOH F O     1 
HETATM 3654 O O     . HOH M 3 .  ? -31.515 14.287  35.047 1.00 47.31 ? 234 HOH F O     1 
HETATM 3655 O O     . HOH M 3 .  ? -36.905 12.919  16.760 1.00 29.96 ? 235 HOH F O     1 
HETATM 3656 O O     . HOH M 3 .  ? -28.143 21.402  36.993 1.00 41.49 ? 236 HOH F O     1 
HETATM 3657 O O     . HOH M 3 .  ? -31.702 17.167  36.016 1.00 25.70 ? 237 HOH F O     1 
HETATM 3658 O O     . HOH M 3 .  ? -30.570 21.669  37.081 1.00 23.49 ? 238 HOH F O     1 
HETATM 3659 O O     . HOH M 3 .  ? -27.754 29.926  11.835 1.00 11.09 ? 239 HOH F O     1 
HETATM 3660 O O     . HOH M 3 .  ? -15.710 14.510  14.065 1.00 18.68 ? 240 HOH F O     1 
HETATM 3661 O O     . HOH M 3 .  ? -25.608 29.325  10.635 1.00 30.90 ? 241 HOH F O     1 
HETATM 3662 O O     . HOH M 3 .  ? -33.336 15.221  35.094 1.00 23.03 ? 242 HOH F O     1 
HETATM 3663 O O     . HOH M 3 .  ? -32.926 12.629  35.246 1.00 26.60 ? 243 HOH F O     1 
HETATM 3664 O O     . HOH N 3 .  ? -4.495  14.423  36.105 1.00 9.64  ? 101 HOH Q O     1 
HETATM 3665 O O     . HOH N 3 .  ? 2.447   -0.628  37.827 1.00 29.37 ? 102 HOH Q O     1 
HETATM 3666 O O     . HOH N 3 .  ? -19.108 26.910  29.896 1.00 17.98 ? 103 HOH Q O     1 
HETATM 3667 O O     . HOH N 3 .  ? -6.727  6.423   39.419 1.00 18.34 ? 104 HOH Q O     1 
HETATM 3668 O O     . HOH N 3 .  ? -29.700 10.212  35.114 1.00 15.17 ? 105 HOH Q O     1 
HETATM 3669 O O     . HOH N 3 .  ? -6.265  19.575  38.353 1.00 36.93 ? 106 HOH Q O     1 
HETATM 3670 O O     . HOH N 3 .  ? -24.150 6.462   38.206 1.00 14.28 ? 107 HOH Q O     1 
HETATM 3671 O O     . HOH N 3 .  ? -29.715 10.783  32.555 1.00 13.19 ? 108 HOH Q O     1 
HETATM 3672 O O     . HOH N 3 .  ? 4.430   19.070  35.888 1.00 12.89 ? 109 HOH Q O     1 
HETATM 3673 O O     . HOH N 3 .  ? -24.677 27.427  26.420 1.00 9.26  ? 110 HOH Q O     1 
HETATM 3674 O O     . HOH N 3 .  ? -20.773 20.219  37.982 1.00 10.94 ? 111 HOH Q O     1 
HETATM 3675 O O     . HOH N 3 .  ? -5.089  1.099   38.657 1.00 25.26 ? 112 HOH Q O     1 
HETATM 3676 O O     . HOH N 3 .  ? -27.134 2.006   35.170 1.00 46.72 ? 113 HOH Q O     1 
HETATM 3677 O O     . HOH N 3 .  ? -26.218 18.275  36.147 1.00 22.45 ? 114 HOH Q O     1 
HETATM 3678 O O     . HOH N 3 .  ? -15.725 0.028   38.788 1.00 30.00 ? 115 HOH Q O     1 
HETATM 3679 O O     . HOH N 3 .  ? -30.647 5.050   34.928 1.00 33.62 ? 116 HOH Q O     1 
HETATM 3680 O O     . HOH N 3 .  ? -10.456 -7.458  35.064 1.00 20.90 ? 117 HOH Q O     1 
HETATM 3681 O O     . HOH N 3 .  ? -5.518  -5.572  35.935 1.00 17.63 ? 118 HOH Q O     1 
HETATM 3682 O O     . HOH N 3 .  ? 8.379   9.455   35.062 1.00 10.91 ? 119 HOH Q O     1 
HETATM 3683 O O     . HOH N 3 .  ? -22.058 0.690   35.187 1.00 15.11 ? 120 HOH Q O     1 
HETATM 3684 O O     . HOH N 3 .  ? -0.128  25.997  31.093 1.00 20.73 ? 121 HOH Q O     1 
HETATM 3685 O O     . HOH N 3 .  ? -20.664 -4.288  39.442 1.00 18.76 ? 122 HOH Q O     1 
HETATM 3686 O O     . HOH N 3 .  ? -21.201 -6.220  31.894 1.00 5.34  ? 123 HOH Q O     1 
HETATM 3687 O O     . HOH N 3 .  ? -12.284 5.601   40.687 1.00 29.96 ? 124 HOH Q O     1 
HETATM 3688 O O     . HOH N 3 .  ? -0.199  9.597   42.398 1.00 27.05 ? 125 HOH Q O     1 
HETATM 3689 O O     . HOH N 3 .  ? -25.828 3.786   38.971 1.00 27.63 ? 126 HOH Q O     1 
HETATM 3690 O O     . HOH N 3 .  ? -9.803  14.601  39.914 1.00 22.45 ? 127 HOH Q O     1 
HETATM 3691 O O     . HOH N 3 .  ? 2.747   17.653  38.675 1.00 31.88 ? 128 HOH Q O     1 
HETATM 3692 O O     . HOH N 3 .  ? -1.706  -7.022  32.994 1.00 7.15  ? 129 HOH Q O     1 
HETATM 3693 O O     . HOH N 3 .  ? -4.977  18.795  30.555 1.00 13.31 ? 130 HOH Q O     1 
HETATM 3694 O O     . HOH N 3 .  ? -6.487  3.851   34.405 1.00 29.21 ? 131 HOH Q O     1 
HETATM 3695 O O     . HOH N 3 .  ? -15.461 19.365  28.952 1.00 11.08 ? 132 HOH Q O     1 
HETATM 3696 O O     . HOH N 3 .  ? -13.014 24.278  34.915 1.00 17.60 ? 133 HOH Q O     1 
HETATM 3697 O O     . HOH N 3 .  ? 8.541   9.272   32.797 1.00 7.98  ? 134 HOH Q O     1 
HETATM 3698 O O     . HOH N 3 .  ? 5.582   7.601   38.917 1.00 19.62 ? 135 HOH Q O     1 
HETATM 3699 O O     . HOH N 3 .  ? 0.649   18.993  35.398 1.00 26.91 ? 136 HOH Q O     1 
HETATM 3700 O O     . HOH N 3 .  ? -19.776 26.965  32.627 1.00 13.38 ? 137 HOH Q O     1 
HETATM 3701 O O     . HOH N 3 .  ? -21.174 10.443  42.722 1.00 24.52 ? 138 HOH Q O     1 
HETATM 3702 O O     . HOH N 3 .  ? -24.711 15.556  34.979 1.00 14.91 ? 139 HOH Q O     1 
HETATM 3703 O O     . HOH N 3 .  ? 3.034   4.319   35.029 1.00 19.24 ? 140 HOH Q O     1 
HETATM 3704 O O     . HOH N 3 .  ? -0.745  25.997  34.314 1.00 12.84 ? 141 HOH Q O     1 
HETATM 3705 O O     . HOH N 3 .  ? -6.766  7.480   41.794 1.00 23.04 ? 142 HOH Q O     1 
HETATM 3706 O O     . HOH N 3 .  ? -20.498 0.515   37.387 1.00 41.63 ? 143 HOH Q O     1 
HETATM 3707 O O     . HOH N 3 .  ? 2.811   1.670   39.283 1.00 15.10 ? 144 HOH Q O     1 
HETATM 3708 O O     . HOH N 3 .  ? -11.144 5.535   39.639 1.00 38.43 ? 145 HOH Q O     1 
HETATM 3709 O O     . HOH N 3 .  ? -23.379 2.149   39.219 1.00 24.11 ? 146 HOH Q O     1 
HETATM 3710 O O     . HOH N 3 .  ? -24.077 14.243  37.122 1.00 17.91 ? 147 HOH Q O     1 
HETATM 3711 O O     . HOH N 3 .  ? -15.556 12.519  44.747 1.00 19.08 ? 148 HOH Q O     1 
HETATM 3712 O O     . HOH N 3 .  ? -7.342  -3.642  37.830 1.00 13.81 ? 149 HOH Q O     1 
HETATM 3713 O O     . HOH N 3 .  ? -21.891 30.465  29.496 1.00 30.00 ? 150 HOH Q O     1 
HETATM 3714 O O     . HOH N 3 .  ? -15.547 7.985   36.866 1.00 26.63 ? 151 HOH Q O     1 
HETATM 3715 O O     . HOH N 3 .  ? -9.388  14.584  45.476 1.00 32.77 ? 152 HOH Q O     1 
HETATM 3716 O O     . HOH N 3 .  ? -13.933 5.896   45.133 1.00 21.90 ? 153 HOH Q O     1 
HETATM 3717 O O     . HOH N 3 .  ? -7.804  10.069  45.879 1.00 12.48 ? 154 HOH Q O     1 
# 
