data_9H41
# 
_entry.id   9H41 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.404 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9H41         pdb_00009h41 10.2210/pdb9h41/pdb 
WWPDB D_1292142491 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-06-11 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9H41 
_pdbx_database_status.recvd_initial_deposition_date   2024-10-17 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              noam@ch.technion.ac.il 
_pdbx_contact_author.name_first         Noam 
_pdbx_contact_author.name_last          Adir 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-2766-8409 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Sklyar, J.' 1 0009-0006-0692-5081 
'Adir, N.'   2 0000-0003-2766-8409 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Int.J.Biol.Macromol. 
_citation.journal_id_ASTM           IJBMDR 
_citation.journal_id_CSD            0708 
_citation.journal_id_ISSN           0141-8130 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            315 
_citation.language                  ? 
_citation.page_first                144290 
_citation.page_last                 144290 
_citation.title                     'The apo-HCP4 structure reveals facets of carotenoid uptake.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.ijbiomac.2025.144290 
_citation.pdbx_database_id_PubMed   40398757 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Sklyar, J.' 1 ? 
primary 'Glaser, F.' 2 ? 
primary 'Adir, N.'   3 ? 
# 
_entity.id                         1 
_entity.type                       polymer 
_entity.src_method                 man 
_entity.pdbx_description           'Orange carotenoid-binding domain-containing protein' 
_entity.formula_weight             18472.998 
_entity.pdbx_number_of_molecules   1 
_entity.pdbx_ec                    ? 
_entity.pdbx_mutation              G151C 
_entity.pdbx_fragment              ? 
_entity.details                    ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;TFTSDSASTRFSQAFGIQTGDAVASTITVFQALSIDDQLAVLWYAYTEMGRSITPAATGAARLQLAEGLLNQIKQMSHAE
QLQVMRDLAAKNNTQVSRSYGILSNNTKLAFWYELSELMVKGFVVPVPTDYKISRDGSQVLEALKGLDFCQQITVLRKVV
ADMGVDPLA
;
_entity_poly.pdbx_seq_one_letter_code_can   
;TFTSDSASTRFSQAFGIQTGDAVASTITVFQALSIDDQLAVLWYAYTEMGRSITPAATGAARLQLAEGLLNQIKQMSHAE
QLQVMRDLAAKNNTQVSRSYGILSNNTKLAFWYELSELMVKGFVVPVPTDYKISRDGSQVLEALKGLDFCQQITVLRKVV
ADMGVDPLA
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   THR n 
1 2   PHE n 
1 3   THR n 
1 4   SER n 
1 5   ASP n 
1 6   SER n 
1 7   ALA n 
1 8   SER n 
1 9   THR n 
1 10  ARG n 
1 11  PHE n 
1 12  SER n 
1 13  GLN n 
1 14  ALA n 
1 15  PHE n 
1 16  GLY n 
1 17  ILE n 
1 18  GLN n 
1 19  THR n 
1 20  GLY n 
1 21  ASP n 
1 22  ALA n 
1 23  VAL n 
1 24  ALA n 
1 25  SER n 
1 26  THR n 
1 27  ILE n 
1 28  THR n 
1 29  VAL n 
1 30  PHE n 
1 31  GLN n 
1 32  ALA n 
1 33  LEU n 
1 34  SER n 
1 35  ILE n 
1 36  ASP n 
1 37  ASP n 
1 38  GLN n 
1 39  LEU n 
1 40  ALA n 
1 41  VAL n 
1 42  LEU n 
1 43  TRP n 
1 44  TYR n 
1 45  ALA n 
1 46  TYR n 
1 47  THR n 
1 48  GLU n 
1 49  MET n 
1 50  GLY n 
1 51  ARG n 
1 52  SER n 
1 53  ILE n 
1 54  THR n 
1 55  PRO n 
1 56  ALA n 
1 57  ALA n 
1 58  THR n 
1 59  GLY n 
1 60  ALA n 
1 61  ALA n 
1 62  ARG n 
1 63  LEU n 
1 64  GLN n 
1 65  LEU n 
1 66  ALA n 
1 67  GLU n 
1 68  GLY n 
1 69  LEU n 
1 70  LEU n 
1 71  ASN n 
1 72  GLN n 
1 73  ILE n 
1 74  LYS n 
1 75  GLN n 
1 76  MET n 
1 77  SER n 
1 78  HIS n 
1 79  ALA n 
1 80  GLU n 
1 81  GLN n 
1 82  LEU n 
1 83  GLN n 
1 84  VAL n 
1 85  MET n 
1 86  ARG n 
1 87  ASP n 
1 88  LEU n 
1 89  ALA n 
1 90  ALA n 
1 91  LYS n 
1 92  ASN n 
1 93  ASN n 
1 94  THR n 
1 95  GLN n 
1 96  VAL n 
1 97  SER n 
1 98  ARG n 
1 99  SER n 
1 100 TYR n 
1 101 GLY n 
1 102 ILE n 
1 103 LEU n 
1 104 SER n 
1 105 ASN n 
1 106 ASN n 
1 107 THR n 
1 108 LYS n 
1 109 LEU n 
1 110 ALA n 
1 111 PHE n 
1 112 TRP n 
1 113 TYR n 
1 114 GLU n 
1 115 LEU n 
1 116 SER n 
1 117 GLU n 
1 118 LEU n 
1 119 MET n 
1 120 VAL n 
1 121 LYS n 
1 122 GLY n 
1 123 PHE n 
1 124 VAL n 
1 125 VAL n 
1 126 PRO n 
1 127 VAL n 
1 128 PRO n 
1 129 THR n 
1 130 ASP n 
1 131 TYR n 
1 132 LYS n 
1 133 ILE n 
1 134 SER n 
1 135 ARG n 
1 136 ASP n 
1 137 GLY n 
1 138 SER n 
1 139 GLN n 
1 140 VAL n 
1 141 LEU n 
1 142 GLU n 
1 143 ALA n 
1 144 LEU n 
1 145 LYS n 
1 146 GLY n 
1 147 LEU n 
1 148 ASP n 
1 149 PHE n 
1 150 CYS n 
1 151 GLN n 
1 152 GLN n 
1 153 ILE n 
1 154 THR n 
1 155 VAL n 
1 156 LEU n 
1 157 ARG n 
1 158 LYS n 
1 159 VAL n 
1 160 VAL n 
1 161 ALA n 
1 162 ASP n 
1 163 MET n 
1 164 GLY n 
1 165 VAL n 
1 166 ASP n 
1 167 PRO n 
1 168 LEU n 
1 169 ALA n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   169 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 all4941 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     103690 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   THR 1   3   ?   ?   ?   A . n 
A 1 2   PHE 2   4   ?   ?   ?   A . n 
A 1 3   THR 3   5   ?   ?   ?   A . n 
A 1 4   SER 4   6   ?   ?   ?   A . n 
A 1 5   ASP 5   7   ?   ?   ?   A . n 
A 1 6   SER 6   8   ?   ?   ?   A . n 
A 1 7   ALA 7   9   ?   ?   ?   A . n 
A 1 8   SER 8   10  ?   ?   ?   A . n 
A 1 9   THR 9   11  ?   ?   ?   A . n 
A 1 10  ARG 10  12  ?   ?   ?   A . n 
A 1 11  PHE 11  13  13  PHE PHE A . n 
A 1 12  SER 12  14  14  SER SER A . n 
A 1 13  GLN 13  15  15  GLN GLN A . n 
A 1 14  ALA 14  16  16  ALA ALA A . n 
A 1 15  PHE 15  17  17  PHE PHE A . n 
A 1 16  GLY 16  18  18  GLY GLY A . n 
A 1 17  ILE 17  19  19  ILE ILE A . n 
A 1 18  GLN 18  20  20  GLN GLN A . n 
A 1 19  THR 19  21  21  THR THR A . n 
A 1 20  GLY 20  22  22  GLY GLY A . n 
A 1 21  ASP 21  23  23  ASP ASP A . n 
A 1 22  ALA 22  24  24  ALA ALA A . n 
A 1 23  VAL 23  25  25  VAL VAL A . n 
A 1 24  ALA 24  26  26  ALA ALA A . n 
A 1 25  SER 25  27  27  SER SER A . n 
A 1 26  THR 26  28  28  THR THR A . n 
A 1 27  ILE 27  29  29  ILE ILE A . n 
A 1 28  THR 28  30  30  THR THR A . n 
A 1 29  VAL 29  31  31  VAL VAL A . n 
A 1 30  PHE 30  32  32  PHE PHE A . n 
A 1 31  GLN 31  33  33  GLN GLN A . n 
A 1 32  ALA 32  34  34  ALA ALA A . n 
A 1 33  LEU 33  35  35  LEU LEU A . n 
A 1 34  SER 34  36  36  SER SER A . n 
A 1 35  ILE 35  37  37  ILE ILE A . n 
A 1 36  ASP 36  38  38  ASP ASP A . n 
A 1 37  ASP 37  39  39  ASP ASP A . n 
A 1 38  GLN 38  40  40  GLN GLN A . n 
A 1 39  LEU 39  41  41  LEU LEU A . n 
A 1 40  ALA 40  42  42  ALA ALA A . n 
A 1 41  VAL 41  43  43  VAL VAL A . n 
A 1 42  LEU 42  44  44  LEU LEU A . n 
A 1 43  TRP 43  45  45  TRP TRP A . n 
A 1 44  TYR 44  46  46  TYR TYR A . n 
A 1 45  ALA 45  47  47  ALA ALA A . n 
A 1 46  TYR 46  48  48  TYR TYR A . n 
A 1 47  THR 47  49  49  THR THR A . n 
A 1 48  GLU 48  50  50  GLU GLU A . n 
A 1 49  MET 49  51  51  MET MET A . n 
A 1 50  GLY 50  52  52  GLY GLY A . n 
A 1 51  ARG 51  53  53  ARG ARG A . n 
A 1 52  SER 52  54  54  SER SER A . n 
A 1 53  ILE 53  55  55  ILE ILE A . n 
A 1 54  THR 54  56  56  THR THR A . n 
A 1 55  PRO 55  57  57  PRO PRO A . n 
A 1 56  ALA 56  58  58  ALA ALA A . n 
A 1 57  ALA 57  59  ?   ?   ?   A . n 
A 1 58  THR 58  60  ?   ?   ?   A . n 
A 1 59  GLY 59  61  ?   ?   ?   A . n 
A 1 60  ALA 60  62  ?   ?   ?   A . n 
A 1 61  ALA 61  63  ?   ?   ?   A . n 
A 1 62  ARG 62  64  ?   ?   ?   A . n 
A 1 63  LEU 63  65  ?   ?   ?   A . n 
A 1 64  GLN 64  66  ?   ?   ?   A . n 
A 1 65  LEU 65  67  ?   ?   ?   A . n 
A 1 66  ALA 66  68  68  ALA ALA A . n 
A 1 67  GLU 67  69  69  GLU GLU A . n 
A 1 68  GLY 68  70  70  GLY GLY A . n 
A 1 69  LEU 69  71  71  LEU LEU A . n 
A 1 70  LEU 70  72  72  LEU LEU A . n 
A 1 71  ASN 71  73  73  ASN ASN A . n 
A 1 72  GLN 72  74  74  GLN GLN A . n 
A 1 73  ILE 73  75  75  ILE ILE A . n 
A 1 74  LYS 74  76  76  LYS LYS A . n 
A 1 75  GLN 75  77  77  GLN GLN A . n 
A 1 76  MET 76  78  78  MET MET A . n 
A 1 77  SER 77  79  79  SER SER A . n 
A 1 78  HIS 78  80  80  HIS HIS A . n 
A 1 79  ALA 79  81  81  ALA ALA A . n 
A 1 80  GLU 80  82  82  GLU GLU A . n 
A 1 81  GLN 81  83  83  GLN GLN A . n 
A 1 82  LEU 82  84  84  LEU LEU A . n 
A 1 83  GLN 83  85  85  GLN GLN A . n 
A 1 84  VAL 84  86  86  VAL VAL A . n 
A 1 85  MET 85  87  87  MET MET A . n 
A 1 86  ARG 86  88  88  ARG ARG A . n 
A 1 87  ASP 87  89  89  ASP ASP A . n 
A 1 88  LEU 88  90  90  LEU LEU A . n 
A 1 89  ALA 89  91  91  ALA ALA A . n 
A 1 90  ALA 90  92  92  ALA ALA A . n 
A 1 91  LYS 91  93  93  LYS LYS A . n 
A 1 92  ASN 92  94  94  ASN ASN A . n 
A 1 93  ASN 93  95  95  ASN ASN A . n 
A 1 94  THR 94  96  96  THR THR A . n 
A 1 95  GLN 95  97  97  GLN GLN A . n 
A 1 96  VAL 96  98  98  VAL VAL A . n 
A 1 97  SER 97  99  99  SER SER A . n 
A 1 98  ARG 98  100 100 ARG ARG A . n 
A 1 99  SER 99  101 101 SER SER A . n 
A 1 100 TYR 100 102 102 TYR TYR A . n 
A 1 101 GLY 101 103 103 GLY GLY A . n 
A 1 102 ILE 102 104 104 ILE ILE A . n 
A 1 103 LEU 103 105 105 LEU LEU A . n 
A 1 104 SER 104 106 106 SER SER A . n 
A 1 105 ASN 105 107 107 ASN ASN A . n 
A 1 106 ASN 106 108 108 ASN ASN A . n 
A 1 107 THR 107 109 109 THR THR A . n 
A 1 108 LYS 108 110 110 LYS LYS A . n 
A 1 109 LEU 109 111 111 LEU LEU A . n 
A 1 110 ALA 110 112 112 ALA ALA A . n 
A 1 111 PHE 111 113 113 PHE PHE A . n 
A 1 112 TRP 112 114 114 TRP TRP A . n 
A 1 113 TYR 113 115 115 TYR TYR A . n 
A 1 114 GLU 114 116 116 GLU GLU A . n 
A 1 115 LEU 115 117 117 LEU LEU A . n 
A 1 116 SER 116 118 118 SER SER A . n 
A 1 117 GLU 117 119 119 GLU GLU A . n 
A 1 118 LEU 118 120 120 LEU LEU A . n 
A 1 119 MET 119 121 121 MET MET A . n 
A 1 120 VAL 120 122 122 VAL VAL A . n 
A 1 121 LYS 121 123 123 LYS LYS A . n 
A 1 122 GLY 122 124 124 GLY GLY A . n 
A 1 123 PHE 123 125 125 PHE PHE A . n 
A 1 124 VAL 124 126 126 VAL VAL A . n 
A 1 125 VAL 125 127 127 VAL VAL A . n 
A 1 126 PRO 126 128 128 PRO PRO A . n 
A 1 127 VAL 127 129 129 VAL VAL A . n 
A 1 128 PRO 128 130 130 PRO PRO A . n 
A 1 129 THR 129 131 131 THR THR A . n 
A 1 130 ASP 130 132 132 ASP ASP A . n 
A 1 131 TYR 131 133 133 TYR TYR A . n 
A 1 132 LYS 132 134 134 LYS LYS A . n 
A 1 133 ILE 133 135 135 ILE ILE A . n 
A 1 134 SER 134 136 136 SER SER A . n 
A 1 135 ARG 135 137 137 ARG ARG A . n 
A 1 136 ASP 136 138 138 ASP ASP A . n 
A 1 137 GLY 137 139 139 GLY GLY A . n 
A 1 138 SER 138 140 140 SER SER A . n 
A 1 139 GLN 139 141 141 GLN GLN A . n 
A 1 140 VAL 140 142 142 VAL VAL A . n 
A 1 141 LEU 141 143 143 LEU LEU A . n 
A 1 142 GLU 142 144 144 GLU GLU A . n 
A 1 143 ALA 143 145 145 ALA ALA A . n 
A 1 144 LEU 144 146 146 LEU LEU A . n 
A 1 145 LYS 145 147 147 LYS LYS A . n 
A 1 146 GLY 146 148 148 GLY GLY A . n 
A 1 147 LEU 147 149 149 LEU LEU A . n 
A 1 148 ASP 148 150 150 ASP ASP A . n 
A 1 149 PHE 149 151 151 PHE PHE A . n 
A 1 150 CYS 150 152 152 CYS CYS A . n 
A 1 151 GLN 151 153 153 GLN GLN A . n 
A 1 152 GLN 152 154 154 GLN GLN A . n 
A 1 153 ILE 153 155 155 ILE ILE A . n 
A 1 154 THR 154 156 156 THR THR A . n 
A 1 155 VAL 155 157 157 VAL VAL A . n 
A 1 156 LEU 156 158 158 LEU LEU A . n 
A 1 157 ARG 157 159 159 ARG ARG A . n 
A 1 158 LYS 158 160 160 LYS LYS A . n 
A 1 159 VAL 159 161 161 VAL VAL A . n 
A 1 160 VAL 160 162 162 VAL VAL A . n 
A 1 161 ALA 161 163 163 ALA ALA A . n 
A 1 162 ASP 162 164 164 ASP ASP A . n 
A 1 163 MET 163 165 165 MET MET A . n 
A 1 164 GLY 164 166 166 GLY GLY A . n 
A 1 165 VAL 165 167 167 VAL VAL A . n 
A 1 166 ASP 166 168 168 ASP ASP A . n 
A 1 167 PRO 167 169 169 PRO PRO A . n 
A 1 168 LEU 168 170 170 LEU LEU A . n 
A 1 169 ALA 169 171 171 ALA ALA A . n 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX    ? ? ? '(1.20.1_4487: ???)' 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS       ? ? ? .                    2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? pointless ? ? ? .                    3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER    ? ? ? .                    4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9H41 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     60.871 
_cell.length_a_esd                 ? 
_cell.length_b                     60.871 
_cell.length_b_esd                 ? 
_cell.length_c                     112.389 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9H41 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                96 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 43 21 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9H41 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.7 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          56.35 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              8.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
;0.08M Tris pH 8.5, 1.6M Ammonium dihydrogen phosphate,
20% v/v Glycerol
;
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2024-09-15 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.9655 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'ESRF BEAMLINE MASSIF-1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.9655 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   MASSIF-1 
_diffrn_source.pdbx_synchrotron_site       ESRF 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9H41 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              3.09 
_reflns.d_resolution_low                               9.97 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     40807 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           96.1 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                10.1 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          11.9 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.994 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.14 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    3.09 
_reflns_shell.d_res_low                                     3.34 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             4175 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.943 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9H41 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            3.09 
_refine.ls_d_res_low                             9.97 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     7010 
_refine.ls_number_reflns_R_free                  347 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    98.12 
_refine.ls_percent_reflns_R_free                 4.95 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2039 
_refine.ls_R_factor_R_free                       0.2425 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2018 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.10 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.90 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 23.62 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.26 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       3.09 
_refine_hist.d_res_low                        9.97 
_refine_hist.number_atoms_solvent             0 
_refine_hist.number_atoms_total               1160 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        1160 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.010 ? ?   ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.161 ? ?   ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 6.163 ? 158 ? f_dihedral_angle_d ? ? 
'X-RAY DIFFRACTION' ? 0.074 ? 188 ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.007 ? 203 ? f_plane_restr      ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 3.09 3.86 . . 179 3257 96.00  . . . . 0.2308 . . . . . . . . . . . 0.2624 
'X-RAY DIFFRACTION' 3.86 9.97 . . 168 3406 100.00 . . . . 0.1837 . . . . . . . . . . . 0.2292 
# 
_struct.entry_id                     9H41 
_struct.title                        'Apo-Helical Carotenoid Protein 4 (HCP4) from Anabaena G152C mutant' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9H41 
_struct_keywords.text            
'Non photochemical quenching Orange carotenoid binding protein Cyanobacteria Phycobilisome Photoprotection, PHOTOSYNTHESIS' 
_struct_keywords.pdbx_keywords   PHOTOSYNTHESIS 
# 
_struct_asym.id                            A 
_struct_asym.pdbx_blank_PDB_chainid_flag   N 
_struct_asym.pdbx_modified                 N 
_struct_asym.entity_id                     1 
_struct_asym.details                       ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    CROTO_NOSS1 
_struct_ref.pdbx_db_accession          Q8YMJ2 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;TFTSDSASTRFSQAFGIQTGDAVASTITVFQALSIDDQLAVLWYAYTEMGRSITPAATGAARLQLAEGLLNQIKQMSHAE
QLQVMRDLAAKNNTQVSRSYGILSNNTKLAFWYELSELMVKGFVVPVPTDYKISRDGSQVLEALKGLDFGQQITVLRKVV
ADMGVDPLA
;
_struct_ref.pdbx_align_begin           2 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9H41 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 169 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q8YMJ2 
_struct_ref_seq.db_align_beg                  2 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  170 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       3 
_struct_ref_seq.pdbx_auth_seq_align_end       171 
# 
_struct_ref_seq_dif.align_id                     1 
_struct_ref_seq_dif.pdbx_pdb_id_code             9H41 
_struct_ref_seq_dif.mon_id                       CYS 
_struct_ref_seq_dif.pdbx_pdb_strand_id           A 
_struct_ref_seq_dif.seq_num                      150 
_struct_ref_seq_dif.pdbx_pdb_ins_code            ? 
_struct_ref_seq_dif.pdbx_seq_db_name             UNP 
_struct_ref_seq_dif.pdbx_seq_db_accession_code   Q8YMJ2 
_struct_ref_seq_dif.db_mon_id                    GLY 
_struct_ref_seq_dif.pdbx_seq_db_seq_num          151 
_struct_ref_seq_dif.details                      'engineered mutation' 
_struct_ref_seq_dif.pdbx_auth_seq_num            152 
_struct_ref_seq_dif.pdbx_ordinal                 1 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 author_defined_assembly   ?    monomeric 1 
2 software_defined_assembly PISA dimeric   2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 0     ? 
1 MORE         0     ? 
1 'SSA (A^2)'  8140  ? 
2 'ABSA (A^2)' 840   ? 
2 MORE         -12   ? 
2 'SSA (A^2)'  15440 ? 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1   A 
2 1,2 A 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z        1.0000000000 0.0000000000  0.0000000000 0.0000000000 0.0000000000  1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  0.0000000000  
2 'crystal symmetry operation' 8_555 -y,-x,-z+1/2 0.0000000000 -1.0000000000 0.0000000000 0.0000000000 -1.0000000000 0.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 56.1945000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 ALA A 22  ? ALA A 32  ? ALA A 24  ALA A 34  1 ? 11 
HELX_P HELX_P2 AA2 SER A 34  ? GLY A 50  ? SER A 36  GLY A 52  1 ? 17 
HELX_P HELX_P3 AA3 GLU A 67  ? GLN A 75  ? GLU A 69  GLN A 77  1 ? 9  
HELX_P HELX_P4 AA4 SER A 77  ? ALA A 90  ? SER A 79  ALA A 92  1 ? 14 
HELX_P HELX_P5 AA5 THR A 94  ? ILE A 102 ? THR A 96  ILE A 104 1 ? 9  
HELX_P HELX_P6 AA6 SER A 104 ? LYS A 121 ? SER A 106 LYS A 123 1 ? 18 
HELX_P HELX_P7 AA7 SER A 134 ? GLY A 146 ? SER A 136 GLY A 148 1 ? 13 
HELX_P HELX_P8 AA8 ASP A 148 ? ASP A 162 ? ASP A 150 ASP A 164 1 ? 15 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_conn.id                            disulf1 
_struct_conn.conn_type_id                  disulf 
_struct_conn.pdbx_leaving_atom_flag        ? 
_struct_conn.pdbx_PDB_id                   ? 
_struct_conn.ptnr1_label_asym_id           A 
_struct_conn.ptnr1_label_comp_id           CYS 
_struct_conn.ptnr1_label_seq_id            150 
_struct_conn.ptnr1_label_atom_id           SG 
_struct_conn.pdbx_ptnr1_label_alt_id       ? 
_struct_conn.pdbx_ptnr1_PDB_ins_code       ? 
_struct_conn.pdbx_ptnr1_standard_comp_id   ? 
_struct_conn.ptnr1_symmetry                1_555 
_struct_conn.ptnr2_label_asym_id           A 
_struct_conn.ptnr2_label_comp_id           CYS 
_struct_conn.ptnr2_label_seq_id            150 
_struct_conn.ptnr2_label_atom_id           SG 
_struct_conn.pdbx_ptnr2_label_alt_id       ? 
_struct_conn.pdbx_ptnr2_PDB_ins_code       ? 
_struct_conn.ptnr1_auth_asym_id            A 
_struct_conn.ptnr1_auth_comp_id            CYS 
_struct_conn.ptnr1_auth_seq_id             152 
_struct_conn.ptnr2_auth_asym_id            A 
_struct_conn.ptnr2_auth_comp_id            CYS 
_struct_conn.ptnr2_auth_seq_id             152 
_struct_conn.ptnr2_symmetry                8_555 
_struct_conn.pdbx_ptnr3_label_atom_id      ? 
_struct_conn.pdbx_ptnr3_label_seq_id       ? 
_struct_conn.pdbx_ptnr3_label_comp_id      ? 
_struct_conn.pdbx_ptnr3_label_asym_id      ? 
_struct_conn.pdbx_ptnr3_label_alt_id       ? 
_struct_conn.pdbx_ptnr3_PDB_ins_code       ? 
_struct_conn.details                       ? 
_struct_conn.pdbx_dist_value               2.051 
_struct_conn.pdbx_value_order              ? 
_struct_conn.pdbx_role                     ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      CYS 
_pdbx_modification_feature.label_asym_id                      A 
_pdbx_modification_feature.label_seq_id                       150 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     CYS 
_pdbx_modification_feature.modified_residue_label_asym_id     A 
_pdbx_modification_feature.modified_residue_label_seq_id      150 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       CYS 
_pdbx_modification_feature.auth_asym_id                       A 
_pdbx_modification_feature.auth_seq_id                        152 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      CYS 
_pdbx_modification_feature.modified_residue_auth_asym_id      A 
_pdbx_modification_feature.modified_residue_auth_seq_id       152 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          8_555 
_pdbx_modification_feature.comp_id_linking_atom               SG 
_pdbx_modification_feature.modified_residue_id_linking_atom   SG 
_pdbx_modification_feature.modified_residue_id                . 
_pdbx_modification_feature.ref_pcm_id                         . 
_pdbx_modification_feature.ref_comp_id                        . 
_pdbx_modification_feature.type                               None 
_pdbx_modification_feature.category                           'Disulfide bridge' 
# 
_pdbx_entry_details.entry_id                   9H41 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
_pdbx_validate_symm_contact.id                1 
_pdbx_validate_symm_contact.PDB_model_num     1 
_pdbx_validate_symm_contact.auth_atom_id_1    O 
_pdbx_validate_symm_contact.auth_asym_id_1    A 
_pdbx_validate_symm_contact.auth_comp_id_1    THR 
_pdbx_validate_symm_contact.auth_seq_id_1     49 
_pdbx_validate_symm_contact.PDB_ins_code_1    ? 
_pdbx_validate_symm_contact.label_alt_id_1    ? 
_pdbx_validate_symm_contact.site_symmetry_1   1_555 
_pdbx_validate_symm_contact.auth_atom_id_2    NH1 
_pdbx_validate_symm_contact.auth_asym_id_2    A 
_pdbx_validate_symm_contact.auth_comp_id_2    ARG 
_pdbx_validate_symm_contact.auth_seq_id_2     100 
_pdbx_validate_symm_contact.PDB_ins_code_2    ? 
_pdbx_validate_symm_contact.label_alt_id_2    ? 
_pdbx_validate_symm_contact.site_symmetry_2   6_545 
_pdbx_validate_symm_contact.dist              2.14 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ALA A 16  ? ? -108.52 49.84   
2 1 ILE A 19  ? ? -88.06  -152.53 
3 1 ALA A 24  ? ? 62.90   -53.58  
4 1 PRO A 57  ? ? -42.90  154.22  
5 1 VAL A 129 ? ? 65.21   156.52  
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A THR 3  ? A THR 1  
2  1 Y 1 A PHE 4  ? A PHE 2  
3  1 Y 1 A THR 5  ? A THR 3  
4  1 Y 1 A SER 6  ? A SER 4  
5  1 Y 1 A ASP 7  ? A ASP 5  
6  1 Y 1 A SER 8  ? A SER 6  
7  1 Y 1 A ALA 9  ? A ALA 7  
8  1 Y 1 A SER 10 ? A SER 8  
9  1 Y 1 A THR 11 ? A THR 9  
10 1 Y 1 A ARG 12 ? A ARG 10 
11 1 Y 1 A ALA 59 ? A ALA 57 
12 1 Y 1 A THR 60 ? A THR 58 
13 1 Y 1 A GLY 61 ? A GLY 59 
14 1 Y 1 A ALA 62 ? A ALA 60 
15 1 Y 1 A ALA 63 ? A ALA 61 
16 1 Y 1 A ARG 64 ? A ARG 62 
17 1 Y 1 A LEU 65 ? A LEU 63 
18 1 Y 1 A GLN 66 ? A GLN 64 
19 1 Y 1 A LEU 67 ? A LEU 65 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
PHE N    N N N 247 
PHE CA   C N S 248 
PHE C    C N N 249 
PHE O    O N N 250 
PHE CB   C N N 251 
PHE CG   C Y N 252 
PHE CD1  C Y N 253 
PHE CD2  C Y N 254 
PHE CE1  C Y N 255 
PHE CE2  C Y N 256 
PHE CZ   C Y N 257 
PHE OXT  O N N 258 
PHE H    H N N 259 
PHE H2   H N N 260 
PHE HA   H N N 261 
PHE HB2  H N N 262 
PHE HB3  H N N 263 
PHE HD1  H N N 264 
PHE HD2  H N N 265 
PHE HE1  H N N 266 
PHE HE2  H N N 267 
PHE HZ   H N N 268 
PHE HXT  H N N 269 
PRO N    N N N 270 
PRO CA   C N S 271 
PRO C    C N N 272 
PRO O    O N N 273 
PRO CB   C N N 274 
PRO CG   C N N 275 
PRO CD   C N N 276 
PRO OXT  O N N 277 
PRO H    H N N 278 
PRO HA   H N N 279 
PRO HB2  H N N 280 
PRO HB3  H N N 281 
PRO HG2  H N N 282 
PRO HG3  H N N 283 
PRO HD2  H N N 284 
PRO HD3  H N N 285 
PRO HXT  H N N 286 
SER N    N N N 287 
SER CA   C N S 288 
SER C    C N N 289 
SER O    O N N 290 
SER CB   C N N 291 
SER OG   O N N 292 
SER OXT  O N N 293 
SER H    H N N 294 
SER H2   H N N 295 
SER HA   H N N 296 
SER HB2  H N N 297 
SER HB3  H N N 298 
SER HG   H N N 299 
SER HXT  H N N 300 
THR N    N N N 301 
THR CA   C N S 302 
THR C    C N N 303 
THR O    O N N 304 
THR CB   C N R 305 
THR OG1  O N N 306 
THR CG2  C N N 307 
THR OXT  O N N 308 
THR H    H N N 309 
THR H2   H N N 310 
THR HA   H N N 311 
THR HB   H N N 312 
THR HG1  H N N 313 
THR HG21 H N N 314 
THR HG22 H N N 315 
THR HG23 H N N 316 
THR HXT  H N N 317 
TRP N    N N N 318 
TRP CA   C N S 319 
TRP C    C N N 320 
TRP O    O N N 321 
TRP CB   C N N 322 
TRP CG   C Y N 323 
TRP CD1  C Y N 324 
TRP CD2  C Y N 325 
TRP NE1  N Y N 326 
TRP CE2  C Y N 327 
TRP CE3  C Y N 328 
TRP CZ2  C Y N 329 
TRP CZ3  C Y N 330 
TRP CH2  C Y N 331 
TRP OXT  O N N 332 
TRP H    H N N 333 
TRP H2   H N N 334 
TRP HA   H N N 335 
TRP HB2  H N N 336 
TRP HB3  H N N 337 
TRP HD1  H N N 338 
TRP HE1  H N N 339 
TRP HE3  H N N 340 
TRP HZ2  H N N 341 
TRP HZ3  H N N 342 
TRP HH2  H N N 343 
TRP HXT  H N N 344 
TYR N    N N N 345 
TYR CA   C N S 346 
TYR C    C N N 347 
TYR O    O N N 348 
TYR CB   C N N 349 
TYR CG   C Y N 350 
TYR CD1  C Y N 351 
TYR CD2  C Y N 352 
TYR CE1  C Y N 353 
TYR CE2  C Y N 354 
TYR CZ   C Y N 355 
TYR OH   O N N 356 
TYR OXT  O N N 357 
TYR H    H N N 358 
TYR H2   H N N 359 
TYR HA   H N N 360 
TYR HB2  H N N 361 
TYR HB3  H N N 362 
TYR HD1  H N N 363 
TYR HD2  H N N 364 
TYR HE1  H N N 365 
TYR HE2  H N N 366 
TYR HH   H N N 367 
TYR HXT  H N N 368 
VAL N    N N N 369 
VAL CA   C N S 370 
VAL C    C N N 371 
VAL O    O N N 372 
VAL CB   C N N 373 
VAL CG1  C N N 374 
VAL CG2  C N N 375 
VAL OXT  O N N 376 
VAL H    H N N 377 
VAL H2   H N N 378 
VAL HA   H N N 379 
VAL HB   H N N 380 
VAL HG11 H N N 381 
VAL HG12 H N N 382 
VAL HG13 H N N 383 
VAL HG21 H N N 384 
VAL HG22 H N N 385 
VAL HG23 H N N 386 
VAL HXT  H N N 387 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
PHE N   CA   sing N N 235 
PHE N   H    sing N N 236 
PHE N   H2   sing N N 237 
PHE CA  C    sing N N 238 
PHE CA  CB   sing N N 239 
PHE CA  HA   sing N N 240 
PHE C   O    doub N N 241 
PHE C   OXT  sing N N 242 
PHE CB  CG   sing N N 243 
PHE CB  HB2  sing N N 244 
PHE CB  HB3  sing N N 245 
PHE CG  CD1  doub Y N 246 
PHE CG  CD2  sing Y N 247 
PHE CD1 CE1  sing Y N 248 
PHE CD1 HD1  sing N N 249 
PHE CD2 CE2  doub Y N 250 
PHE CD2 HD2  sing N N 251 
PHE CE1 CZ   doub Y N 252 
PHE CE1 HE1  sing N N 253 
PHE CE2 CZ   sing Y N 254 
PHE CE2 HE2  sing N N 255 
PHE CZ  HZ   sing N N 256 
PHE OXT HXT  sing N N 257 
PRO N   CA   sing N N 258 
PRO N   CD   sing N N 259 
PRO N   H    sing N N 260 
PRO CA  C    sing N N 261 
PRO CA  CB   sing N N 262 
PRO CA  HA   sing N N 263 
PRO C   O    doub N N 264 
PRO C   OXT  sing N N 265 
PRO CB  CG   sing N N 266 
PRO CB  HB2  sing N N 267 
PRO CB  HB3  sing N N 268 
PRO CG  CD   sing N N 269 
PRO CG  HG2  sing N N 270 
PRO CG  HG3  sing N N 271 
PRO CD  HD2  sing N N 272 
PRO CD  HD3  sing N N 273 
PRO OXT HXT  sing N N 274 
SER N   CA   sing N N 275 
SER N   H    sing N N 276 
SER N   H2   sing N N 277 
SER CA  C    sing N N 278 
SER CA  CB   sing N N 279 
SER CA  HA   sing N N 280 
SER C   O    doub N N 281 
SER C   OXT  sing N N 282 
SER CB  OG   sing N N 283 
SER CB  HB2  sing N N 284 
SER CB  HB3  sing N N 285 
SER OG  HG   sing N N 286 
SER OXT HXT  sing N N 287 
THR N   CA   sing N N 288 
THR N   H    sing N N 289 
THR N   H2   sing N N 290 
THR CA  C    sing N N 291 
THR CA  CB   sing N N 292 
THR CA  HA   sing N N 293 
THR C   O    doub N N 294 
THR C   OXT  sing N N 295 
THR CB  OG1  sing N N 296 
THR CB  CG2  sing N N 297 
THR CB  HB   sing N N 298 
THR OG1 HG1  sing N N 299 
THR CG2 HG21 sing N N 300 
THR CG2 HG22 sing N N 301 
THR CG2 HG23 sing N N 302 
THR OXT HXT  sing N N 303 
TRP N   CA   sing N N 304 
TRP N   H    sing N N 305 
TRP N   H2   sing N N 306 
TRP CA  C    sing N N 307 
TRP CA  CB   sing N N 308 
TRP CA  HA   sing N N 309 
TRP C   O    doub N N 310 
TRP C   OXT  sing N N 311 
TRP CB  CG   sing N N 312 
TRP CB  HB2  sing N N 313 
TRP CB  HB3  sing N N 314 
TRP CG  CD1  doub Y N 315 
TRP CG  CD2  sing Y N 316 
TRP CD1 NE1  sing Y N 317 
TRP CD1 HD1  sing N N 318 
TRP CD2 CE2  doub Y N 319 
TRP CD2 CE3  sing Y N 320 
TRP NE1 CE2  sing Y N 321 
TRP NE1 HE1  sing N N 322 
TRP CE2 CZ2  sing Y N 323 
TRP CE3 CZ3  doub Y N 324 
TRP CE3 HE3  sing N N 325 
TRP CZ2 CH2  doub Y N 326 
TRP CZ2 HZ2  sing N N 327 
TRP CZ3 CH2  sing Y N 328 
TRP CZ3 HZ3  sing N N 329 
TRP CH2 HH2  sing N N 330 
TRP OXT HXT  sing N N 331 
TYR N   CA   sing N N 332 
TYR N   H    sing N N 333 
TYR N   H2   sing N N 334 
TYR CA  C    sing N N 335 
TYR CA  CB   sing N N 336 
TYR CA  HA   sing N N 337 
TYR C   O    doub N N 338 
TYR C   OXT  sing N N 339 
TYR CB  CG   sing N N 340 
TYR CB  HB2  sing N N 341 
TYR CB  HB3  sing N N 342 
TYR CG  CD1  doub Y N 343 
TYR CG  CD2  sing Y N 344 
TYR CD1 CE1  sing Y N 345 
TYR CD1 HD1  sing N N 346 
TYR CD2 CE2  doub Y N 347 
TYR CD2 HD2  sing N N 348 
TYR CE1 CZ   doub Y N 349 
TYR CE1 HE1  sing N N 350 
TYR CE2 CZ   sing Y N 351 
TYR CE2 HE2  sing N N 352 
TYR CZ  OH   sing N N 353 
TYR OH  HH   sing N N 354 
TYR OXT HXT  sing N N 355 
VAL N   CA   sing N N 356 
VAL N   H    sing N N 357 
VAL N   H2   sing N N 358 
VAL CA  C    sing N N 359 
VAL CA  CB   sing N N 360 
VAL CA  HA   sing N N 361 
VAL C   O    doub N N 362 
VAL C   OXT  sing N N 363 
VAL CB  CG1  sing N N 364 
VAL CB  CG2  sing N N 365 
VAL CB  HB   sing N N 366 
VAL CG1 HG11 sing N N 367 
VAL CG1 HG12 sing N N 368 
VAL CG1 HG13 sing N N 369 
VAL CG2 HG21 sing N N 370 
VAL CG2 HG22 sing N N 371 
VAL CG2 HG23 sing N N 372 
VAL OXT HXT  sing N N 373 
# 
_pdbx_audit_support.funding_organization   'Israel Science Foundation' 
_pdbx_audit_support.country                Israel 
_pdbx_audit_support.grant_number           1596/21 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   8QX5 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9H41 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.016428 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.016428 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.008898 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM 1    N N   . PHE A 1 11  ? 9.754   17.676  25.629 1.00 49.74 ? 13  PHE A N   1 
ATOM 2    C CA  . PHE A 1 11  ? 9.798   18.687  26.714 1.00 56.22 ? 13  PHE A CA  1 
ATOM 3    C C   . PHE A 1 11  ? 11.164  19.364  26.735 1.00 57.35 ? 13  PHE A C   1 
ATOM 4    O O   . PHE A 1 11  ? 12.166  18.703  26.437 1.00 53.36 ? 13  PHE A O   1 
ATOM 5    C CB  . PHE A 1 11  ? 9.499   18.063  28.079 1.00 53.27 ? 13  PHE A CB  1 
ATOM 6    C CG  . PHE A 1 11  ? 8.602   18.900  28.952 1.00 58.07 ? 13  PHE A CG  1 
ATOM 7    C CD1 . PHE A 1 11  ? 8.685   20.282  28.932 1.00 70.20 ? 13  PHE A CD1 1 
ATOM 8    C CD2 . PHE A 1 11  ? 7.666   18.310  29.783 1.00 65.90 ? 13  PHE A CD2 1 
ATOM 9    C CE1 . PHE A 1 11  ? 7.857   21.056  29.728 1.00 79.18 ? 13  PHE A CE1 1 
ATOM 10   C CE2 . PHE A 1 11  ? 6.838   19.084  30.578 1.00 70.81 ? 13  PHE A CE2 1 
ATOM 11   C CZ  . PHE A 1 11  ? 6.935   20.454  30.550 1.00 73.02 ? 13  PHE A CZ  1 
ATOM 12   N N   . SER A 1 12  ? 11.182  20.652  27.078 1.00 61.82 ? 14  SER A N   1 
ATOM 13   C CA  . SER A 1 12  ? 12.454  21.406  27.157 1.00 53.54 ? 14  SER A CA  1 
ATOM 14   C C   . SER A 1 12  ? 13.325  20.775  28.240 1.00 55.85 ? 14  SER A C   1 
ATOM 15   O O   . SER A 1 12  ? 14.517  21.110  28.293 1.00 55.77 ? 14  SER A O   1 
ATOM 16   C CB  . SER A 1 12  ? 12.188  22.856  27.409 1.00 51.30 ? 14  SER A CB  1 
ATOM 17   O OG  . SER A 1 12  ? 11.862  23.523  26.200 1.00 63.02 ? 14  SER A OG  1 
ATOM 18   N N   . GLN A 1 13  ? 12.765  19.854  29.030 1.00 30.00 ? 15  GLN A N   1 
ATOM 19   C CA  . GLN A 1 13  ? 13.598  19.117  30.016 1.00 30.00 ? 15  GLN A CA  1 
ATOM 20   C C   . GLN A 1 13  ? 14.439  18.098  29.240 1.00 30.00 ? 15  GLN A C   1 
ATOM 21   O O   . GLN A 1 13  ? 14.156  16.891  29.351 1.00 30.00 ? 15  GLN A O   1 
ATOM 22   C CB  . GLN A 1 13  ? 12.712  18.441  31.064 1.00 30.00 ? 15  GLN A CB  1 
ATOM 23   C CG  . GLN A 1 13  ? 13.492  17.753  32.176 1.00 30.00 ? 15  GLN A CG  1 
ATOM 24   C CD  . GLN A 1 13  ? 13.912  18.706  33.267 1.00 30.00 ? 15  GLN A CD  1 
ATOM 25   O OE1 . GLN A 1 13  ? 14.711  18.369  34.138 1.00 30.00 ? 15  GLN A OE1 1 
ATOM 26   N NE2 . GLN A 1 13  ? 13.375  19.915  33.227 1.00 30.00 ? 15  GLN A NE2 1 
ATOM 27   N N   . ALA A 1 14  ? 15.409  18.574  28.453 1.00 68.60 ? 16  ALA A N   1 
ATOM 28   C CA  . ALA A 1 14  ? 16.237  17.668  27.623 1.00 56.59 ? 16  ALA A CA  1 
ATOM 29   C C   . ALA A 1 14  ? 17.651  17.593  28.206 1.00 68.88 ? 16  ALA A C   1 
ATOM 30   O O   . ALA A 1 14  ? 18.618  17.763  27.440 1.00 51.46 ? 16  ALA A O   1 
ATOM 31   C CB  . ALA A 1 14  ? 16.250  18.155  26.195 1.00 31.00 ? 16  ALA A CB  1 
ATOM 32   N N   . PHE A 1 15  ? 17.758  17.344  29.513 1.00 66.58 ? 17  PHE A N   1 
ATOM 33   C CA  . PHE A 1 15  ? 19.075  17.276  30.183 1.00 41.24 ? 17  PHE A CA  1 
ATOM 34   C C   . PHE A 1 15  ? 19.680  15.948  29.751 1.00 40.31 ? 17  PHE A C   1 
ATOM 35   O O   . PHE A 1 15  ? 20.706  15.551  30.307 1.00 50.74 ? 17  PHE A O   1 
ATOM 36   C CB  . PHE A 1 15  ? 18.879  17.342  31.694 1.00 32.87 ? 17  PHE A CB  1 
ATOM 37   C CG  . PHE A 1 15  ? 18.393  18.665  32.222 1.00 36.48 ? 17  PHE A CG  1 
ATOM 38   C CD1 . PHE A 1 15  ? 17.093  19.083  32.005 1.00 36.60 ? 17  PHE A CD1 1 
ATOM 39   C CD2 . PHE A 1 15  ? 19.237  19.486  32.949 1.00 35.71 ? 17  PHE A CD2 1 
ATOM 40   C CE1 . PHE A 1 15  ? 16.652  20.300  32.496 1.00 36.99 ? 17  PHE A CE1 1 
ATOM 41   C CE2 . PHE A 1 15  ? 18.794  20.701  33.441 1.00 29.96 ? 17  PHE A CE2 1 
ATOM 42   C CZ  . PHE A 1 15  ? 17.502  21.106  33.214 1.00 27.85 ? 17  PHE A CZ  1 
ATOM 43   N N   . GLY A 1 16  ? 19.034  15.279  28.794 1.00 39.62 ? 18  GLY A N   1 
ATOM 44   C CA  . GLY A 1 16  ? 19.527  13.995  28.270 1.00 34.94 ? 18  GLY A CA  1 
ATOM 45   C C   . GLY A 1 16  ? 18.657  12.874  28.769 1.00 36.73 ? 18  GLY A C   1 
ATOM 46   O O   . GLY A 1 16  ? 19.189  11.777  28.991 1.00 43.05 ? 18  GLY A O   1 
ATOM 47   N N   . ILE A 1 17  ? 17.355  13.134  28.937 1.00 40.30 ? 19  ILE A N   1 
ATOM 48   C CA  . ILE A 1 17  ? 16.434  12.127  29.521 1.00 41.21 ? 19  ILE A CA  1 
ATOM 49   C C   . ILE A 1 17  ? 15.914  11.266  28.368 1.00 49.97 ? 19  ILE A C   1 
ATOM 50   O O   . ILE A 1 17  ? 16.671  11.004  27.407 1.00 61.85 ? 19  ILE A O   1 
ATOM 51   C CB  . ILE A 1 17  ? 15.273  12.796  30.283 1.00 30.00 ? 19  ILE A CB  1 
ATOM 52   C CG1 . ILE A 1 17  ? 15.800  13.539  31.512 1.00 30.00 ? 19  ILE A CG1 1 
ATOM 53   C CG2 . ILE A 1 17  ? 14.234  11.761  30.684 1.00 30.00 ? 19  ILE A CG2 1 
ATOM 54   C CD1 . ILE A 1 17  ? 14.774  14.436  32.167 1.00 30.00 ? 19  ILE A CD1 1 
ATOM 55   N N   . GLN A 1 18  ? 14.708  10.704  28.528 1.00 51.10 ? 20  GLN A N   1 
ATOM 56   C CA  . GLN A 1 18  ? 14.195  9.752   27.509 1.00 57.97 ? 20  GLN A CA  1 
ATOM 57   C C   . GLN A 1 18  ? 14.172  10.233  26.060 1.00 75.62 ? 20  GLN A C   1 
ATOM 58   O O   . GLN A 1 18  ? 14.288  11.453  25.828 1.00 80.43 ? 20  GLN A O   1 
ATOM 59   C CB  . GLN A 1 18  ? 12.773  9.316   27.846 1.00 64.73 ? 20  GLN A CB  1 
ATOM 60   C CG  . GLN A 1 18  ? 11.717  10.391  27.610 1.00 79.49 ? 20  GLN A CG  1 
ATOM 61   C CD  . GLN A 1 18  ? 10.876  10.150  26.375 1.00 85.10 ? 20  GLN A CD  1 
ATOM 62   O OE1 . GLN A 1 18  ? 10.128  9.171   26.283 1.00 79.48 ? 20  GLN A OE1 1 
ATOM 63   N NE2 . GLN A 1 18  ? 10.992  11.049  25.409 1.00 76.24 ? 20  GLN A NE2 1 
ATOM 64   N N   . THR A 1 19  ? 14.002  9.296   25.127 1.00 82.52 ? 21  THR A N   1 
ATOM 65   C CA  . THR A 1 19  ? 13.934  9.646   23.695 1.00 86.54 ? 21  THR A CA  1 
ATOM 66   C C   . THR A 1 19  ? 12.756  8.929   23.076 1.00 87.95 ? 21  THR A C   1 
ATOM 67   O O   . THR A 1 19  ? 12.623  9.006   21.837 1.00 96.28 ? 21  THR A O   1 
ATOM 68   C CB  . THR A 1 19  ? 15.238  9.287   22.983 1.00 85.94 ? 21  THR A CB  1 
ATOM 69   O OG1 . THR A 1 19  ? 16.186  8.929   23.984 1.00 82.31 ? 21  THR A OG1 1 
ATOM 70   C CG2 . THR A 1 19  ? 15.786  10.446  22.170 1.00 68.68 ? 21  THR A CG2 1 
ATOM 71   N N   . GLY A 1 20  ? 11.935  8.240   23.877 1.00 75.88 ? 22  GLY A N   1 
ATOM 72   C CA  . GLY A 1 20  ? 10.716  7.633   23.312 1.00 72.75 ? 22  GLY A CA  1 
ATOM 73   C C   . GLY A 1 20  ? 10.431  6.237   23.823 1.00 67.94 ? 22  GLY A C   1 
ATOM 74   O O   . GLY A 1 20  ? 10.997  5.869   24.870 1.00 69.32 ? 22  GLY A O   1 
ATOM 75   N N   . ASP A 1 21  ? 9.583   5.487   23.108 1.00 57.59 ? 23  ASP A N   1 
ATOM 76   C CA  . ASP A 1 21  ? 9.185   4.130   23.567 1.00 49.74 ? 23  ASP A CA  1 
ATOM 77   C C   . ASP A 1 21  ? 9.915   3.065   22.750 1.00 46.85 ? 23  ASP A C   1 
ATOM 78   O O   . ASP A 1 21  ? 10.090  1.969   23.308 1.00 55.26 ? 23  ASP A O   1 
ATOM 79   C CB  . ASP A 1 21  ? 7.676   3.943   23.564 1.00 43.91 ? 23  ASP A CB  1 
ATOM 80   C CG  . ASP A 1 21  ? 7.134   2.779   24.380 1.00 45.19 ? 23  ASP A CG  1 
ATOM 81   O OD1 . ASP A 1 21  ? 7.882   2.251   25.223 1.00 51.29 ? 23  ASP A OD1 1 
ATOM 82   O OD2 . ASP A 1 21  ? 5.962   2.413   24.169 1.00 47.98 ? 23  ASP A OD2 1 
ATOM 83   N N   . ALA A 1 22  ? 10.336  3.373   21.522 1.00 37.95 ? 24  ALA A N   1 
ATOM 84   C CA  . ALA A 1 22  ? 10.968  2.341   20.660 1.00 44.46 ? 24  ALA A CA  1 
ATOM 85   C C   . ALA A 1 22  ? 9.958   1.236   20.371 1.00 44.19 ? 24  ALA A C   1 
ATOM 86   O O   . ALA A 1 22  ? 9.756   0.911   19.195 1.00 43.62 ? 24  ALA A O   1 
ATOM 87   C CB  . ALA A 1 22  ? 12.217  1.783   21.280 1.00 32.58 ? 24  ALA A CB  1 
ATOM 88   N N   . VAL A 1 23  ? 9.364   0.661   21.406 1.00 42.47 ? 25  VAL A N   1 
ATOM 89   C CA  . VAL A 1 23  ? 8.273   -0.317  21.163 1.00 38.12 ? 25  VAL A CA  1 
ATOM 90   C C   . VAL A 1 23  ? 7.149   0.460   20.480 1.00 41.87 ? 25  VAL A C   1 
ATOM 91   O O   . VAL A 1 23  ? 6.625   -0.038  19.484 1.00 40.67 ? 25  VAL A O   1 
ATOM 92   C CB  . VAL A 1 23  ? 7.799   -0.979  22.468 1.00 38.21 ? 25  VAL A CB  1 
ATOM 93   C CG1 . VAL A 1 23  ? 6.529   -1.784  22.263 1.00 26.90 ? 25  VAL A CG1 1 
ATOM 94   C CG2 . VAL A 1 23  ? 8.885   -1.834  23.092 1.00 38.93 ? 25  VAL A CG2 1 
ATOM 95   N N   . ALA A 1 24  ? 6.825   1.661   20.968 1.00 42.33 ? 26  ALA A N   1 
ATOM 96   C CA  . ALA A 1 24  ? 5.798   2.415   20.264 1.00 36.83 ? 26  ALA A CA  1 
ATOM 97   C C   . ALA A 1 24  ? 6.285   2.825   18.882 1.00 38.19 ? 26  ALA A C   1 
ATOM 98   O O   . ALA A 1 24  ? 5.535   2.730   17.906 1.00 40.57 ? 26  ALA A O   1 
ATOM 99   C CB  . ALA A 1 24  ? 5.354   3.630   21.071 1.00 32.62 ? 26  ALA A CB  1 
ATOM 100  N N   . SER A 1 25  ? 7.546   3.245   18.766 1.00 35.67 ? 27  SER A N   1 
ATOM 101  C CA  . SER A 1 25  ? 8.052   3.666   17.462 1.00 37.42 ? 27  SER A CA  1 
ATOM 102  C C   . SER A 1 25  ? 7.918   2.548   16.438 1.00 35.09 ? 27  SER A C   1 
ATOM 103  O O   . SER A 1 25  ? 7.456   2.773   15.314 1.00 32.29 ? 27  SER A O   1 
ATOM 104  C CB  . SER A 1 25  ? 9.506   4.111   17.583 1.00 43.49 ? 27  SER A CB  1 
ATOM 105  O OG  . SER A 1 25  ? 9.617   5.174   18.514 1.00 63.90 ? 27  SER A OG  1 
ATOM 106  N N   . THR A 1 26  ? 8.302   1.326   16.823 1.00 38.22 ? 28  THR A N   1 
ATOM 107  C CA  . THR A 1 26  ? 8.215   0.184   15.917 1.00 35.10 ? 28  THR A CA  1 
ATOM 108  C C   . THR A 1 26  ? 6.770   -0.104  15.526 1.00 31.06 ? 28  THR A C   1 
ATOM 109  O O   . THR A 1 26  ? 6.469   -0.355  14.354 1.00 26.76 ? 28  THR A O   1 
ATOM 110  C CB  . THR A 1 26  ? 8.843   -1.043  16.573 1.00 32.11 ? 28  THR A CB  1 
ATOM 111  O OG1 . THR A 1 26  ? 10.075  -0.666  17.186 1.00 33.41 ? 28  THR A OG1 1 
ATOM 112  C CG2 . THR A 1 26  ? 9.121   -2.105  15.546 1.00 30.56 ? 28  THR A CG2 1 
ATOM 113  N N   . ILE A 1 27  ? 5.861   -0.082  16.497 1.00 29.88 ? 29  ILE A N   1 
ATOM 114  C CA  . ILE A 1 27  ? 4.460   -0.273  16.163 1.00 30.38 ? 29  ILE A CA  1 
ATOM 115  C C   . ILE A 1 27  ? 4.020   0.769   15.150 1.00 29.37 ? 29  ILE A C   1 
ATOM 116  O O   . ILE A 1 27  ? 3.324   0.455   14.180 1.00 33.74 ? 29  ILE A O   1 
ATOM 117  C CB  . ILE A 1 27  ? 3.598   -0.251  17.435 1.00 23.89 ? 29  ILE A CB  1 
ATOM 118  C CG1 . ILE A 1 27  ? 3.913   -1.484  18.260 1.00 25.03 ? 29  ILE A CG1 1 
ATOM 119  C CG2 . ILE A 1 27  ? 2.140   -0.251  17.082 1.00 19.66 ? 29  ILE A CG2 1 
ATOM 120  C CD1 . ILE A 1 27  ? 3.589   -1.337  19.676 1.00 28.69 ? 29  ILE A CD1 1 
ATOM 121  N N   . THR A 1 28  ? 4.453   2.013   15.328 1.00 27.56 ? 30  THR A N   1 
ATOM 122  C CA  . THR A 1 28  ? 4.057   3.041   14.377 1.00 30.11 ? 30  THR A CA  1 
ATOM 123  C C   . THR A 1 28  ? 4.631   2.742   13.000 1.00 29.10 ? 30  THR A C   1 
ATOM 124  O O   . THR A 1 28  ? 3.891   2.669   12.013 1.00 33.50 ? 30  THR A O   1 
ATOM 125  C CB  . THR A 1 28  ? 4.485   4.441   14.850 1.00 36.26 ? 30  THR A CB  1 
ATOM 126  O OG1 . THR A 1 28  ? 4.117   4.654   16.221 1.00 37.93 ? 30  THR A OG1 1 
ATOM 127  C CG2 . THR A 1 28  ? 3.800   5.501   14.017 1.00 31.14 ? 30  THR A CG2 1 
ATOM 128  N N   . VAL A 1 29  ? 5.946   2.544   12.911 1.00 26.61 ? 31  VAL A N   1 
ATOM 129  C CA  . VAL A 1 29  ? 6.536   2.371   11.591 1.00 25.99 ? 31  VAL A CA  1 
ATOM 130  C C   . VAL A 1 29  ? 6.011   1.104   10.955 1.00 32.07 ? 31  VAL A C   1 
ATOM 131  O O   . VAL A 1 29  ? 5.927   1.007   9.724  1.00 36.72 ? 31  VAL A O   1 
ATOM 132  C CB  . VAL A 1 29  ? 8.072   2.358   11.657 1.00 25.84 ? 31  VAL A CB  1 
ATOM 133  C CG1 . VAL A 1 29  ? 8.593   3.745   11.940 1.00 30.16 ? 31  VAL A CG1 1 
ATOM 134  C CG2 . VAL A 1 29  ? 8.563   1.365   12.676 1.00 28.83 ? 31  VAL A CG2 1 
ATOM 135  N N   . PHE A 1 30  ? 5.648   0.114   11.774 1.00 34.29 ? 32  PHE A N   1 
ATOM 136  C CA  . PHE A 1 30  ? 5.041   -1.094  11.237 1.00 28.83 ? 32  PHE A CA  1 
ATOM 137  C C   . PHE A 1 30  ? 3.733   -0.750  10.556 1.00 31.51 ? 32  PHE A C   1 
ATOM 138  O O   . PHE A 1 30  ? 3.544   -1.010  9.363  1.00 33.27 ? 32  PHE A O   1 
ATOM 139  C CB  . PHE A 1 30  ? 4.789   -2.116  12.345 1.00 28.57 ? 32  PHE A CB  1 
ATOM 140  C CG  . PHE A 1 30  ? 4.103   -3.358  11.853 1.00 32.99 ? 32  PHE A CG  1 
ATOM 141  C CD1 . PHE A 1 30  ? 4.842   -4.399  11.301 1.00 30.86 ? 32  PHE A CD1 1 
ATOM 142  C CD2 . PHE A 1 30  ? 2.714   -3.452  11.855 1.00 30.80 ? 32  PHE A CD2 1 
ATOM 143  C CE1 . PHE A 1 30  ? 4.213   -5.543  10.824 1.00 27.18 ? 32  PHE A CE1 1 
ATOM 144  C CE2 . PHE A 1 30  ? 2.082   -4.578  11.364 1.00 27.76 ? 32  PHE A CE2 1 
ATOM 145  C CZ  . PHE A 1 30  ? 2.832   -5.628  10.851 1.00 27.99 ? 32  PHE A CZ  1 
ATOM 146  N N   . GLN A 1 31  ? 2.820   -0.141  11.314 1.00 33.68 ? 33  GLN A N   1 
ATOM 147  C CA  . GLN A 1 31  ? 1.476   0.172   10.854 1.00 31.41 ? 33  GLN A CA  1 
ATOM 148  C C   . GLN A 1 31  ? 1.437   1.217   9.745  1.00 31.76 ? 33  GLN A C   1 
ATOM 149  O O   . GLN A 1 31  ? 0.373   1.419   9.150  1.00 30.65 ? 33  GLN A O   1 
ATOM 150  C CB  . GLN A 1 31  ? 0.642   0.593   12.055 1.00 24.43 ? 33  GLN A CB  1 
ATOM 151  C CG  . GLN A 1 31  ? 0.483   -0.588  12.984 1.00 31.63 ? 33  GLN A CG  1 
ATOM 152  C CD  . GLN A 1 31  ? -0.252  -0.271  14.261 1.00 39.69 ? 33  GLN A CD  1 
ATOM 153  O OE1 . GLN A 1 31  ? 0.020   0.738   14.900 1.00 37.42 ? 33  GLN A OE1 1 
ATOM 154  N NE2 . GLN A 1 31  ? -1.200  -1.145  14.646 1.00 43.13 ? 33  GLN A NE2 1 
ATOM 155  N N   . ALA A 1 32  ? 2.562   1.852   9.429  1.00 30.20 ? 34  ALA A N   1 
ATOM 156  C CA  . ALA A 1 32  ? 2.667   2.679   8.240  1.00 28.97 ? 34  ALA A CA  1 
ATOM 157  C C   . ALA A 1 32  ? 3.069   1.884   7.002  1.00 33.26 ? 34  ALA A C   1 
ATOM 158  O O   . ALA A 1 32  ? 3.352   2.483   5.964  1.00 38.36 ? 34  ALA A O   1 
ATOM 159  C CB  . ALA A 1 32  ? 3.673   3.799   8.468  1.00 30.96 ? 34  ALA A CB  1 
ATOM 160  N N   . LEU A 1 33  ? 3.115   0.562   7.084  1.00 33.81 ? 35  LEU A N   1 
ATOM 161  C CA  . LEU A 1 33  ? 3.590   -0.260  5.981  1.00 32.14 ? 35  LEU A CA  1 
ATOM 162  C C   . LEU A 1 33  ? 2.410   -0.729  5.148  1.00 30.95 ? 35  LEU A C   1 
ATOM 163  O O   . LEU A 1 33  ? 1.264   -0.747  5.613  1.00 30.61 ? 35  LEU A O   1 
ATOM 164  C CB  . LEU A 1 33  ? 4.367   -1.474  6.501  1.00 33.03 ? 35  LEU A CB  1 
ATOM 165  C CG  . LEU A 1 33  ? 5.829   -1.355  6.938  1.00 31.94 ? 35  LEU A CG  1 
ATOM 166  C CD1 . LEU A 1 33  ? 6.333   -2.741  7.310  1.00 28.40 ? 35  LEU A CD1 1 
ATOM 167  C CD2 . LEU A 1 33  ? 6.703   -0.726  5.851  1.00 31.40 ? 35  LEU A CD2 1 
ATOM 168  N N   . SER A 1 34  ? 2.706   -1.128  3.910  1.00 27.88 ? 36  SER A N   1 
ATOM 169  C CA  . SER A 1 34  ? 1.681   -1.717  3.060  1.00 27.17 ? 36  SER A CA  1 
ATOM 170  C C   . SER A 1 34  ? 1.168   -3.016  3.691  1.00 29.99 ? 36  SER A C   1 
ATOM 171  O O   . SER A 1 34  ? 1.731   -3.528  4.655  1.00 38.97 ? 36  SER A O   1 
ATOM 172  C CB  . SER A 1 34  ? 2.237   -1.961  1.657  1.00 31.35 ? 36  SER A CB  1 
ATOM 173  O OG  . SER A 1 34  ? 2.932   -3.189  1.558  1.00 35.34 ? 36  SER A OG  1 
ATOM 174  N N   . ILE A 1 35  ? 0.070   -3.550  3.160  1.00 27.74 ? 37  ILE A N   1 
ATOM 175  C CA  . ILE A 1 35  ? -0.451  -4.798  3.714  1.00 25.25 ? 37  ILE A CA  1 
ATOM 176  C C   . ILE A 1 35  ? 0.570   -5.918  3.539  1.00 26.04 ? 37  ILE A C   1 
ATOM 177  O O   . ILE A 1 35  ? 0.900   -6.625  4.499  1.00 25.15 ? 37  ILE A O   1 
ATOM 178  C CB  . ILE A 1 35  ? -1.810  -5.159  3.084  1.00 27.07 ? 37  ILE A CB  1 
ATOM 179  C CG1 . ILE A 1 35  ? -2.939  -4.205  3.515  1.00 22.49 ? 37  ILE A CG1 1 
ATOM 180  C CG2 . ILE A 1 35  ? -2.202  -6.574  3.462  1.00 26.57 ? 37  ILE A CG2 1 
ATOM 181  C CD1 . ILE A 1 35  ? -2.913  -3.760  4.969  1.00 23.61 ? 37  ILE A CD1 1 
ATOM 182  N N   . ASP A 1 36  ? 1.111   -6.076  2.317  1.00 27.39 ? 38  ASP A N   1 
ATOM 183  C CA  . ASP A 1 36  ? 2.040   -7.177  2.038  1.00 29.87 ? 38  ASP A CA  1 
ATOM 184  C C   . ASP A 1 36  ? 3.276   -7.099  2.913  1.00 32.46 ? 38  ASP A C   1 
ATOM 185  O O   . ASP A 1 36  ? 3.742   -8.113  3.454  1.00 30.70 ? 38  ASP A O   1 
ATOM 186  C CB  . ASP A 1 36  ? 2.486   -7.176  0.581  1.00 32.95 ? 38  ASP A CB  1 
ATOM 187  C CG  . ASP A 1 36  ? 1.392   -7.532  -0.374 1.00 39.24 ? 38  ASP A CG  1 
ATOM 188  O OD1 . ASP A 1 36  ? 0.287   -7.922  0.078  1.00 37.75 ? 38  ASP A OD1 1 
ATOM 189  O OD2 . ASP A 1 36  ? 1.666   -7.435  -1.595 1.00 43.63 ? 38  ASP A OD2 1 
ATOM 190  N N   . ASP A 1 37  ? 3.860   -5.904  2.999  1.00 29.23 ? 39  ASP A N   1 
ATOM 191  C CA  . ASP A 1 37  ? 4.961   -5.664  3.915  1.00 27.01 ? 39  ASP A CA  1 
ATOM 192  C C   . ASP A 1 37  ? 4.603   -6.112  5.326  1.00 26.42 ? 39  ASP A C   1 
ATOM 193  O O   . ASP A 1 37  ? 5.366   -6.840  5.968  1.00 30.70 ? 39  ASP A O   1 
ATOM 194  C CB  . ASP A 1 37  ? 5.314   -4.182  3.888  1.00 31.93 ? 39  ASP A CB  1 
ATOM 195  C CG  . ASP A 1 37  ? 6.276   -3.828  2.770  1.00 35.70 ? 39  ASP A CG  1 
ATOM 196  O OD1 . ASP A 1 37  ? 6.849   -4.747  2.128  1.00 33.97 ? 39  ASP A OD1 1 
ATOM 197  O OD2 . ASP A 1 37  ? 6.427   -2.608  2.530  1.00 39.80 ? 39  ASP A OD2 1 
ATOM 198  N N   . GLN A 1 38  ? 3.430   -5.703  5.818  1.00 25.07 ? 40  GLN A N   1 
ATOM 199  C CA  . GLN A 1 38  ? 3.012   -6.098  7.160  1.00 24.39 ? 40  GLN A CA  1 
ATOM 200  C C   . GLN A 1 38  ? 2.877   -7.605  7.281  1.00 27.06 ? 40  GLN A C   1 
ATOM 201  O O   . GLN A 1 38  ? 3.329   -8.200  8.266  1.00 25.83 ? 40  GLN A O   1 
ATOM 202  C CB  . GLN A 1 38  ? 1.697   -5.424  7.525  1.00 26.50 ? 40  GLN A CB  1 
ATOM 203  C CG  . GLN A 1 38  ? 1.861   -3.941  7.714  1.00 32.64 ? 40  GLN A CG  1 
ATOM 204  C CD  . GLN A 1 38  ? 0.582   -3.254  8.071  1.00 30.40 ? 40  GLN A CD  1 
ATOM 205  O OE1 . GLN A 1 38  ? -0.355  -3.883  8.581  1.00 28.57 ? 40  GLN A OE1 1 
ATOM 206  N NE2 . GLN A 1 38  ? 0.516   -1.951  7.787  1.00 29.69 ? 40  GLN A NE2 1 
ATOM 207  N N   . LEU A 1 39  ? 2.242   -8.240  6.297  1.00 28.60 ? 41  LEU A N   1 
ATOM 208  C CA  . LEU A 1 39  ? 2.171   -9.693  6.299  1.00 24.61 ? 41  LEU A CA  1 
ATOM 209  C C   . LEU A 1 39  ? 3.566   -10.296 6.287  1.00 28.91 ? 41  LEU A C   1 
ATOM 210  O O   . LEU A 1 39  ? 3.898   -11.142 7.126  1.00 29.93 ? 41  LEU A O   1 
ATOM 211  C CB  . LEU A 1 39  ? 1.350   -10.174 5.109  1.00 25.76 ? 41  LEU A CB  1 
ATOM 212  C CG  . LEU A 1 39  ? -0.146  -10.215 5.398  1.00 25.86 ? 41  LEU A CG  1 
ATOM 213  C CD1 . LEU A 1 39  ? -0.337  -11.075 6.592  1.00 31.30 ? 41  LEU A CD1 1 
ATOM 214  C CD2 . LEU A 1 39  ? -0.705  -8.886  5.700  1.00 27.90 ? 41  LEU A CD2 1 
ATOM 215  N N   . ALA A 1 40  ? 4.412   -9.838  5.363  1.00 30.14 ? 42  ALA A N   1 
ATOM 216  C CA  . ALA A 1 40  ? 5.787   -10.320 5.304  1.00 29.44 ? 42  ALA A CA  1 
ATOM 217  C C   . ALA A 1 40  ? 6.483   -10.176 6.649  1.00 28.01 ? 42  ALA A C   1 
ATOM 218  O O   . ALA A 1 40  ? 6.923   -11.169 7.240  1.00 33.33 ? 42  ALA A O   1 
ATOM 219  C CB  . ALA A 1 40  ? 6.558   -9.571  4.225  1.00 29.29 ? 42  ALA A CB  1 
ATOM 220  N N   . VAL A 1 41  ? 6.585   -8.937  7.149  1.00 25.52 ? 43  VAL A N   1 
ATOM 221  C CA  . VAL A 1 41  ? 7.285   -8.670  8.406  1.00 25.22 ? 43  VAL A CA  1 
ATOM 222  C C   . VAL A 1 41  ? 6.749   -9.554  9.506  1.00 25.60 ? 43  VAL A C   1 
ATOM 223  O O   . VAL A 1 41  ? 7.506   -10.024 10.365 1.00 27.25 ? 43  VAL A O   1 
ATOM 224  C CB  . VAL A 1 41  ? 7.172   -7.176  8.788  1.00 23.22 ? 43  VAL A CB  1 
ATOM 225  C CG1 . VAL A 1 41  ? 7.519   -6.955  10.248 1.00 19.28 ? 43  VAL A CG1 1 
ATOM 226  C CG2 . VAL A 1 41  ? 8.081   -6.350  7.918  1.00 25.58 ? 43  VAL A CG2 1 
ATOM 227  N N   . LEU A 1 42  ? 5.447   -9.833  9.479  1.00 23.16 ? 44  LEU A N   1 
ATOM 228  C CA  . LEU A 1 42  ? 4.848   -10.579 10.573 1.00 24.50 ? 44  LEU A CA  1 
ATOM 229  C C   . LEU A 1 42  ? 5.376   -11.999 10.618 1.00 27.91 ? 44  LEU A C   1 
ATOM 230  O O   . LEU A 1 42  ? 5.810   -12.470 11.672 1.00 31.98 ? 44  LEU A O   1 
ATOM 231  C CB  . LEU A 1 42  ? 3.335   -10.563 10.449 1.00 26.82 ? 44  LEU A CB  1 
ATOM 232  C CG  . LEU A 1 42  ? 2.744   -9.401  11.229 1.00 26.01 ? 44  LEU A CG  1 
ATOM 233  C CD1 . LEU A 1 42  ? 1.231   -9.544  11.254 1.00 24.29 ? 44  LEU A CD1 1 
ATOM 234  C CD2 . LEU A 1 42  ? 3.349   -9.355  12.633 1.00 16.98 ? 44  LEU A CD2 1 
ATOM 235  N N   . TRP A 1 43  ? 5.387   -12.696 9.487  1.00 29.60 ? 45  TRP A N   1 
ATOM 236  C CA  . TRP A 1 43  ? 5.798   -14.088 9.591  1.00 33.94 ? 45  TRP A CA  1 
ATOM 237  C C   . TRP A 1 43  ? 7.302   -14.280 9.636  1.00 35.94 ? 45  TRP A C   1 
ATOM 238  O O   . TRP A 1 43  ? 7.746   -15.314 10.140 1.00 39.68 ? 45  TRP A O   1 
ATOM 239  C CB  . TRP A 1 43  ? 5.131   -14.921 8.500  1.00 34.41 ? 45  TRP A CB  1 
ATOM 240  C CG  . TRP A 1 43  ? 5.696   -14.987 7.153  1.00 33.78 ? 45  TRP A CG  1 
ATOM 241  C CD1 . TRP A 1 43  ? 5.765   -13.959 6.254  1.00 42.98 ? 45  TRP A CD1 1 
ATOM 242  C CD2 . TRP A 1 43  ? 6.057   -16.174 6.431  1.00 31.57 ? 45  TRP A CD2 1 
ATOM 243  N NE1 . TRP A 1 43  ? 6.234   -14.422 5.032  1.00 49.81 ? 45  TRP A NE1 1 
ATOM 244  C CE2 . TRP A 1 43  ? 6.414   -15.776 5.113  1.00 37.94 ? 45  TRP A CE2 1 
ATOM 245  C CE3 . TRP A 1 43  ? 6.157   -17.514 6.777  1.00 28.65 ? 45  TRP A CE3 1 
ATOM 246  C CZ2 . TRP A 1 43  ? 6.862   -16.669 4.154  1.00 29.22 ? 45  TRP A CZ2 1 
ATOM 247  C CZ3 . TRP A 1 43  ? 6.595   -18.405 5.820  1.00 39.96 ? 45  TRP A CZ3 1 
ATOM 248  C CH2 . TRP A 1 43  ? 6.947   -17.978 4.522  1.00 39.61 ? 45  TRP A CH2 1 
ATOM 249  N N   . TYR A 1 44  ? 8.106   -13.306 9.210  1.00 32.77 ? 46  TYR A N   1 
ATOM 250  C CA  . TYR A 1 44  ? 9.518   -13.382 9.561  1.00 28.81 ? 46  TYR A CA  1 
ATOM 251  C C   . TYR A 1 44  ? 9.658   -13.370 11.081 1.00 30.37 ? 46  TYR A C   1 
ATOM 252  O O   . TYR A 1 44  ? 10.252  -14.278 11.679 1.00 28.83 ? 46  TYR A O   1 
ATOM 253  C CB  . TYR A 1 44  ? 10.299  -12.223 8.921  1.00 33.24 ? 46  TYR A CB  1 
ATOM 254  C CG  . TYR A 1 44  ? 11.816  -12.358 9.060  1.00 34.65 ? 46  TYR A CG  1 
ATOM 255  C CD1 . TYR A 1 44  ? 12.433  -12.219 10.292 1.00 33.44 ? 46  TYR A CD1 1 
ATOM 256  C CD2 . TYR A 1 44  ? 12.621  -12.635 7.956  1.00 27.75 ? 46  TYR A CD2 1 
ATOM 257  C CE1 . TYR A 1 44  ? 13.784  -12.370 10.432 1.00 34.34 ? 46  TYR A CE1 1 
ATOM 258  C CE2 . TYR A 1 44  ? 13.973  -12.777 8.092  1.00 27.51 ? 46  TYR A CE2 1 
ATOM 259  C CZ  . TYR A 1 44  ? 14.549  -12.644 9.338  1.00 33.78 ? 46  TYR A CZ  1 
ATOM 260  O OH  . TYR A 1 44  ? 15.903  -12.775 9.521  1.00 42.00 ? 46  TYR A OH  1 
ATOM 261  N N   . ALA A 1 45  ? 9.040   -12.372 11.724 1.00 33.85 ? 47  ALA A N   1 
ATOM 262  C CA  . ALA A 1 45  ? 9.103   -12.176 13.168 1.00 31.06 ? 47  ALA A CA  1 
ATOM 263  C C   . ALA A 1 45  ? 8.339   -13.245 13.960 1.00 33.58 ? 47  ALA A C   1 
ATOM 264  O O   . ALA A 1 45  ? 8.513   -13.349 15.175 1.00 35.45 ? 47  ALA A O   1 
ATOM 265  C CB  . ALA A 1 45  ? 8.571   -10.779 13.496 1.00 19.70 ? 47  ALA A CB  1 
ATOM 266  N N   . TYR A 1 46  ? 7.487   -14.033 13.327 1.00 32.29 ? 48  TYR A N   1 
ATOM 267  C CA  . TYR A 1 46  ? 6.832   -15.104 14.056 1.00 28.29 ? 48  TYR A CA  1 
ATOM 268  C C   . TYR A 1 46  ? 7.532   -16.436 13.851 1.00 34.94 ? 48  TYR A C   1 
ATOM 269  O O   . TYR A 1 46  ? 7.750   -17.164 14.823 1.00 38.44 ? 48  TYR A O   1 
ATOM 270  C CB  . TYR A 1 46  ? 5.367   -15.184 13.638 1.00 31.49 ? 48  TYR A CB  1 
ATOM 271  C CG  . TYR A 1 46  ? 4.495   -14.329 14.522 1.00 31.31 ? 48  TYR A CG  1 
ATOM 272  C CD1 . TYR A 1 46  ? 4.104   -14.761 15.772 1.00 30.08 ? 48  TYR A CD1 1 
ATOM 273  C CD2 . TYR A 1 46  ? 4.159   -13.039 14.146 1.00 31.21 ? 48  TYR A CD2 1 
ATOM 274  C CE1 . TYR A 1 46  ? 3.331   -13.961 16.593 1.00 29.89 ? 48  TYR A CE1 1 
ATOM 275  C CE2 . TYR A 1 46  ? 3.400   -12.231 14.958 1.00 30.89 ? 48  TYR A CE2 1 
ATOM 276  C CZ  . TYR A 1 46  ? 2.989   -12.694 16.188 1.00 29.80 ? 48  TYR A CZ  1 
ATOM 277  O OH  . TYR A 1 46  ? 2.224   -11.878 17.006 1.00 31.14 ? 48  TYR A OH  1 
ATOM 278  N N   . THR A 1 47  ? 7.912   -16.750 12.607 1.00 32.53 ? 49  THR A N   1 
ATOM 279  C CA  . THR A 1 47  ? 8.865   -17.824 12.351 1.00 26.64 ? 49  THR A CA  1 
ATOM 280  C C   . THR A 1 47  ? 10.048  -17.774 13.298 1.00 34.85 ? 49  THR A C   1 
ATOM 281  O O   . THR A 1 47  ? 10.537  -18.823 13.732 1.00 35.59 ? 49  THR A O   1 
ATOM 282  C CB  . THR A 1 47  ? 9.396   -17.740 10.927 1.00 30.88 ? 49  THR A CB  1 
ATOM 283  O OG1 . THR A 1 47  ? 8.309   -17.531 10.029 1.00 48.80 ? 49  THR A OG1 1 
ATOM 284  C CG2 . THR A 1 47  ? 10.120  -19.010 10.543 1.00 33.45 ? 49  THR A CG2 1 
ATOM 285  N N   . GLU A 1 48  ? 10.565  -16.574 13.607 1.00 36.27 ? 50  GLU A N   1 
ATOM 286  C CA  . GLU A 1 48  ? 11.760  -16.583 14.445 1.00 34.60 ? 50  GLU A CA  1 
ATOM 287  C C   . GLU A 1 48  ? 11.397  -16.701 15.926 1.00 35.98 ? 50  GLU A C   1 
ATOM 288  O O   . GLU A 1 48  ? 11.944  -17.561 16.630 1.00 34.70 ? 50  GLU A O   1 
ATOM 289  C CB  . GLU A 1 48  ? 12.673  -15.382 14.147 1.00 26.41 ? 50  GLU A CB  1 
ATOM 290  C CG  . GLU A 1 48  ? 12.254  -13.997 14.555 1.00 34.24 ? 50  GLU A CG  1 
ATOM 291  C CD  . GLU A 1 48  ? 13.380  -12.969 14.289 1.00 38.45 ? 50  GLU A CD  1 
ATOM 292  O OE1 . GLU A 1 48  ? 14.253  -13.257 13.438 1.00 37.36 ? 50  GLU A OE1 1 
ATOM 293  O OE2 . GLU A 1 48  ? 13.403  -11.882 14.920 1.00 38.57 ? 50  GLU A OE2 1 
ATOM 294  N N   . MET A 1 49  ? 10.437  -15.896 16.403 1.00 35.09 ? 51  MET A N   1 
ATOM 295  C CA  . MET A 1 49  ? 9.974   -16.030 17.782 1.00 29.43 ? 51  MET A CA  1 
ATOM 296  C C   . MET A 1 49  ? 9.570   -17.456 18.095 1.00 33.79 ? 51  MET A C   1 
ATOM 297  O O   . MET A 1 49  ? 9.845   -17.964 19.189 1.00 34.91 ? 51  MET A O   1 
ATOM 298  C CB  . MET A 1 49  ? 8.815   -15.083 18.043 1.00 30.70 ? 51  MET A CB  1 
ATOM 299  C CG  . MET A 1 49  ? 9.286   -13.689 18.349 1.00 30.73 ? 51  MET A CG  1 
ATOM 300  S SD  . MET A 1 49  ? 9.653   -13.653 20.103 1.00 43.07 ? 51  MET A SD  1 
ATOM 301  C CE  . MET A 1 49  ? 10.795  -12.286 20.222 1.00 31.53 ? 51  MET A CE  1 
ATOM 302  N N   . GLY A 1 50  ? 8.952   -18.127 17.136 1.00 31.30 ? 52  GLY A N   1 
ATOM 303  C CA  . GLY A 1 50  ? 8.661   -19.532 17.319 1.00 31.10 ? 52  GLY A CA  1 
ATOM 304  C C   . GLY A 1 50  ? 7.631   -19.694 18.405 1.00 37.03 ? 52  GLY A C   1 
ATOM 305  O O   . GLY A 1 50  ? 6.562   -19.073 18.364 1.00 43.31 ? 52  GLY A O   1 
ATOM 306  N N   . ARG A 1 51  ? 7.972   -20.509 19.408 1.00 39.91 ? 53  ARG A N   1 
ATOM 307  C CA  . ARG A 1 51  ? 7.085   -20.852 20.515 1.00 44.73 ? 53  ARG A CA  1 
ATOM 308  C C   . ARG A 1 51  ? 7.308   -19.994 21.750 1.00 46.22 ? 53  ARG A C   1 
ATOM 309  O O   . ARG A 1 51  ? 6.737   -20.285 22.802 1.00 56.65 ? 53  ARG A O   1 
ATOM 310  C CB  . ARG A 1 51  ? 7.249   -22.331 20.879 1.00 42.10 ? 53  ARG A CB  1 
ATOM 311  C CG  . ARG A 1 51  ? 6.078   -23.159 20.450 1.00 52.55 ? 53  ARG A CG  1 
ATOM 312  C CD  . ARG A 1 51  ? 6.434   -24.608 20.312 1.00 60.18 ? 53  ARG A CD  1 
ATOM 313  N NE  . ARG A 1 51  ? 5.247   -25.450 20.285 1.00 72.32 ? 53  ARG A NE  1 
ATOM 314  C CZ  . ARG A 1 51  ? 5.281   -26.764 20.122 1.00 80.34 ? 53  ARG A CZ  1 
ATOM 315  N NH1 . ARG A 1 51  ? 6.424   -27.404 19.917 1.00 68.21 ? 53  ARG A NH1 1 
ATOM 316  N NH2 . ARG A 1 51  ? 4.139   -27.448 20.136 1.00 87.57 ? 53  ARG A NH2 1 
ATOM 317  N N   . SER A 1 52  ? 8.113   -18.947 21.653 1.00 43.67 ? 54  SER A N   1 
ATOM 318  C CA  . SER A 1 52  ? 8.464   -18.162 22.822 1.00 44.02 ? 54  SER A CA  1 
ATOM 319  C C   . SER A 1 52  ? 7.493   -17.021 23.093 1.00 50.20 ? 54  SER A C   1 
ATOM 320  O O   . SER A 1 52  ? 7.607   -16.366 24.135 1.00 58.54 ? 54  SER A O   1 
ATOM 321  C CB  . SER A 1 52  ? 9.889   -17.633 22.665 1.00 46.78 ? 54  SER A CB  1 
ATOM 322  O OG  . SER A 1 52  ? 10.768  -18.720 22.407 1.00 52.80 ? 54  SER A OG  1 
ATOM 323  N N   . ILE A 1 53  ? 6.537   -16.829 22.189 1.00 46.78 ? 55  ILE A N   1 
ATOM 324  C CA  . ILE A 1 53  ? 5.552   -15.720 22.323 1.00 58.20 ? 55  ILE A CA  1 
ATOM 325  C C   . ILE A 1 53  ? 4.459   -16.149 23.303 1.00 64.58 ? 55  ILE A C   1 
ATOM 326  O O   . ILE A 1 53  ? 4.218   -15.408 24.270 1.00 67.60 ? 55  ILE A O   1 
ATOM 327  C CB  . ILE A 1 53  ? 4.990   -15.337 20.938 1.00 53.59 ? 55  ILE A CB  1 
ATOM 328  C CG1 . ILE A 1 53  ? 5.729   -16.064 19.814 1.00 59.27 ? 55  ILE A CG1 1 
ATOM 329  C CG2 . ILE A 1 53  ? 5.007   -13.829 20.740 1.00 37.09 ? 55  ILE A CG2 1 
ATOM 330  C CD1 . ILE A 1 53  ? 4.843   -16.481 18.669 1.00 56.04 ? 55  ILE A CD1 1 
ATOM 331  N N   . THR A 1 54  ? 3.817   -17.290 23.056 1.00 64.14 ? 56  THR A N   1 
ATOM 332  C CA  . THR A 1 54  ? 2.803   -17.832 23.994 1.00 70.21 ? 56  THR A CA  1 
ATOM 333  C C   . THR A 1 54  ? 3.352   -19.138 24.569 1.00 75.59 ? 56  THR A C   1 
ATOM 334  O O   . THR A 1 54  ? 4.363   -19.614 24.035 1.00 75.61 ? 56  THR A O   1 
ATOM 335  C CB  . THR A 1 54  ? 1.467   -18.033 23.272 1.00 65.86 ? 56  THR A CB  1 
ATOM 336  O OG1 . THR A 1 54  ? 0.397   -17.781 24.184 1.00 62.65 ? 56  THR A OG1 1 
ATOM 337  C CG2 . THR A 1 54  ? 1.327   -19.418 22.677 1.00 59.38 ? 56  THR A CG2 1 
ATOM 338  N N   . PRO A 1 55  ? 2.773   -19.734 25.634 1.00 85.10 ? 57  PRO A N   1 
ATOM 339  C CA  . PRO A 1 55  ? 3.227   -21.045 26.119 1.00 83.01 ? 57  PRO A CA  1 
ATOM 340  C C   . PRO A 1 55  ? 3.491   -22.022 24.962 1.00 82.19 ? 57  PRO A C   1 
ATOM 341  O O   . PRO A 1 55  ? 2.898   -21.861 23.914 1.00 79.83 ? 57  PRO A O   1 
ATOM 342  C CB  . PRO A 1 55  ? 2.031   -21.507 26.955 1.00 67.65 ? 57  PRO A CB  1 
ATOM 343  C CG  . PRO A 1 55  ? 0.849   -20.856 26.276 1.00 70.95 ? 57  PRO A CG  1 
ATOM 344  C CD  . PRO A 1 55  ? 1.346   -19.491 25.845 1.00 75.29 ? 57  PRO A CD  1 
ATOM 345  N N   . ALA A 1 56  ? 4.366   -23.008 25.169 1.00 72.30 ? 58  ALA A N   1 
ATOM 346  C CA  . ALA A 1 56  ? 4.722   -23.926 24.060 1.00 77.89 ? 58  ALA A CA  1 
ATOM 347  C C   . ALA A 1 56  ? 3.450   -24.317 23.294 1.00 84.24 ? 58  ALA A C   1 
ATOM 348  O O   . ALA A 1 56  ? 3.405   -24.037 22.079 1.00 79.06 ? 58  ALA A O   1 
ATOM 349  C CB  . ALA A 1 56  ? 5.467   -25.138 24.570 1.00 54.50 ? 58  ALA A CB  1 
ATOM 350  N N   . ALA A 1 66  ? -9.814  -20.555 17.587 1.00 41.81 ? 68  ALA A N   1 
ATOM 351  C CA  . ALA A 1 66  ? -8.394  -20.416 17.249 1.00 42.09 ? 68  ALA A CA  1 
ATOM 352  C C   . ALA A 1 66  ? -7.950  -21.562 16.381 1.00 41.05 ? 68  ALA A C   1 
ATOM 353  O O   . ALA A 1 66  ? -7.598  -21.396 15.221 1.00 39.08 ? 68  ALA A O   1 
ATOM 354  C CB  . ALA A 1 66  ? -7.544  -20.376 18.492 1.00 35.67 ? 68  ALA A CB  1 
ATOM 355  N N   . GLU A 1 67  ? -7.967  -22.742 16.994 1.00 50.92 ? 69  GLU A N   1 
ATOM 356  C CA  . GLU A 1 67  ? -7.576  -23.974 16.325 1.00 47.08 ? 69  GLU A CA  1 
ATOM 357  C C   . GLU A 1 67  ? -8.464  -24.285 15.117 1.00 40.43 ? 69  GLU A C   1 
ATOM 358  O O   . GLU A 1 67  ? -8.002  -24.944 14.181 1.00 39.99 ? 69  GLU A O   1 
ATOM 359  C CB  . GLU A 1 67  ? -7.570  -25.100 17.376 1.00 49.31 ? 69  GLU A CB  1 
ATOM 360  C CG  . GLU A 1 67  ? -6.908  -24.691 18.772 1.00 65.07 ? 69  GLU A CG  1 
ATOM 361  C CD  . GLU A 1 67  ? -7.832  -23.967 19.814 1.00 60.47 ? 69  GLU A CD  1 
ATOM 362  O OE1 . GLU A 1 67  ? -9.062  -24.216 19.813 1.00 56.51 ? 69  GLU A OE1 1 
ATOM 363  O OE2 . GLU A 1 67  ? -7.312  -23.161 20.648 1.00 38.74 ? 69  GLU A OE2 1 
ATOM 364  N N   . GLY A 1 68  ? -9.703  -23.783 15.092 1.00 40.01 ? 70  GLY A N   1 
ATOM 365  C CA  . GLY A 1 68  ? -10.622 -23.991 13.980 1.00 36.29 ? 70  GLY A CA  1 
ATOM 366  C C   . GLY A 1 68  ? -10.633 -22.888 12.930 1.00 40.29 ? 70  GLY A C   1 
ATOM 367  O O   . GLY A 1 68  ? -10.859 -23.163 11.745 1.00 36.77 ? 70  GLY A O   1 
ATOM 368  N N   . LEU A 1 69  ? -10.418 -21.629 13.344 1.00 36.92 ? 71  LEU A N   1 
ATOM 369  C CA  . LEU A 1 69  ? -10.113 -20.591 12.363 1.00 25.35 ? 71  LEU A CA  1 
ATOM 370  C C   . LEU A 1 69  ? -8.922  -20.982 11.520 1.00 31.69 ? 71  LEU A C   1 
ATOM 371  O O   . LEU A 1 69  ? -8.877  -20.690 10.320 1.00 34.60 ? 71  LEU A O   1 
ATOM 372  C CB  . LEU A 1 69  ? -9.837  -19.255 13.042 1.00 27.54 ? 71  LEU A CB  1 
ATOM 373  C CG  . LEU A 1 69  ? -9.466  -18.136 12.057 1.00 25.29 ? 71  LEU A CG  1 
ATOM 374  C CD1 . LEU A 1 69  ? -10.572 -17.829 11.062 1.00 23.16 ? 71  LEU A CD1 1 
ATOM 375  C CD2 . LEU A 1 69  ? -9.062  -16.864 12.820 1.00 23.37 ? 71  LEU A CD2 1 
ATOM 376  N N   . LEU A 1 70  ? -7.939  -21.639 12.138 1.00 33.71 ? 72  LEU A N   1 
ATOM 377  C CA  . LEU A 1 70  ? -6.759  -22.046 11.399 1.00 29.17 ? 72  LEU A CA  1 
ATOM 378  C C   . LEU A 1 70  ? -7.127  -23.063 10.348 1.00 30.65 ? 72  LEU A C   1 
ATOM 379  O O   . LEU A 1 70  ? -6.655  -22.984 9.208  1.00 31.13 ? 72  LEU A O   1 
ATOM 380  C CB  . LEU A 1 70  ? -5.712  -22.597 12.353 1.00 30.99 ? 72  LEU A CB  1 
ATOM 381  C CG  . LEU A 1 70  ? -4.894  -21.437 12.915 1.00 32.98 ? 72  LEU A CG  1 
ATOM 382  C CD1 . LEU A 1 70  ? -4.092  -21.897 14.120 1.00 32.34 ? 72  LEU A CD1 1 
ATOM 383  C CD2 . LEU A 1 70  ? -4.003  -20.812 11.838 1.00 28.98 ? 72  LEU A CD2 1 
ATOM 384  N N   . ASN A 1 71  ? -8.009  -24.002 10.695 1.00 32.80 ? 73  ASN A N   1 
ATOM 385  C CA  . ASN A 1 71  ? -8.418  -24.977 9.698  1.00 36.09 ? 73  ASN A CA  1 
ATOM 386  C C   . ASN A 1 71  ? -9.053  -24.293 8.501  1.00 33.21 ? 73  ASN A C   1 
ATOM 387  O O   . ASN A 1 71  ? -8.710  -24.591 7.355  1.00 36.03 ? 73  ASN A O   1 
ATOM 388  C CB  . ASN A 1 71  ? -9.379  -26.004 10.268 1.00 35.97 ? 73  ASN A CB  1 
ATOM 389  C CG  . ASN A 1 71  ? -9.566  -27.171 9.313  1.00 53.72 ? 73  ASN A CG  1 
ATOM 390  O OD1 . ASN A 1 71  ? -8.760  -27.363 8.392  1.00 52.96 ? 73  ASN A OD1 1 
ATOM 391  N ND2 . ASN A 1 71  ? -10.658 -27.912 9.474  1.00 66.78 ? 73  ASN A ND2 1 
ATOM 392  N N   . GLN A 1 72  ? -9.964  -23.355 8.748  1.00 30.52 ? 74  GLN A N   1 
ATOM 393  C CA  . GLN A 1 72  ? -10.626 -22.685 7.635  1.00 32.50 ? 74  GLN A CA  1 
ATOM 394  C C   . GLN A 1 72  ? -9.604  -22.053 6.703  1.00 33.08 ? 74  GLN A C   1 
ATOM 395  O O   . GLN A 1 72  ? -9.671  -22.227 5.478  1.00 34.07 ? 74  GLN A O   1 
ATOM 396  C CB  . GLN A 1 72  ? -11.614 -21.636 8.146  1.00 29.05 ? 74  GLN A CB  1 
ATOM 397  C CG  . GLN A 1 72  ? -12.467 -21.045 7.038  1.00 26.97 ? 74  GLN A CG  1 
ATOM 398  C CD  . GLN A 1 72  ? -13.196 -19.787 7.453  1.00 24.98 ? 74  GLN A CD  1 
ATOM 399  O OE1 . GLN A 1 72  ? -13.407 -19.542 8.635  1.00 27.24 ? 74  GLN A OE1 1 
ATOM 400  N NE2 . GLN A 1 72  ? -13.603 -18.991 6.474  1.00 24.44 ? 74  GLN A NE2 1 
ATOM 401  N N   . ILE A 1 73  ? -8.631  -21.332 7.267  1.00 31.48 ? 75  ILE A N   1 
ATOM 402  C CA  . ILE A 1 73  ? -7.575  -20.761 6.437  1.00 31.91 ? 75  ILE A CA  1 
ATOM 403  C C   . ILE A 1 73  ? -6.737  -21.869 5.819  1.00 35.43 ? 75  ILE A C   1 
ATOM 404  O O   . ILE A 1 73  ? -6.446  -21.844 4.617  1.00 37.35 ? 75  ILE A O   1 
ATOM 405  C CB  . ILE A 1 73  ? -6.700  -19.773 7.235  1.00 34.83 ? 75  ILE A CB  1 
ATOM 406  C CG1 . ILE A 1 73  ? -7.545  -18.664 7.874  1.00 32.27 ? 75  ILE A CG1 1 
ATOM 407  C CG2 . ILE A 1 73  ? -5.601  -19.174 6.348  1.00 33.94 ? 75  ILE A CG2 1 
ATOM 408  C CD1 . ILE A 1 73  ? -6.718  -17.592 8.552  1.00 27.36 ? 75  ILE A CD1 1 
ATOM 409  N N   . LYS A 1 74  ? -6.358  -22.876 6.623  1.00 35.47 ? 76  LYS A N   1 
ATOM 410  C CA  . LYS A 1 74  ? -5.421  -23.883 6.124  1.00 35.52 ? 76  LYS A CA  1 
ATOM 411  C C   . LYS A 1 74  ? -5.945  -24.535 4.856  1.00 30.88 ? 76  LYS A C   1 
ATOM 412  O O   . LYS A 1 74  ? -5.163  -24.864 3.960  1.00 31.56 ? 76  LYS A O   1 
ATOM 413  C CB  . LYS A 1 74  ? -5.125  -24.946 7.187  1.00 31.49 ? 76  LYS A CB  1 
ATOM 414  C CG  . LYS A 1 74  ? -4.619  -26.269 6.611  1.00 33.92 ? 76  LYS A CG  1 
ATOM 415  C CD  . LYS A 1 74  ? -4.126  -27.249 7.682  1.00 42.50 ? 76  LYS A CD  1 
ATOM 416  C CE  . LYS A 1 74  ? -5.225  -27.682 8.671  1.00 49.12 ? 76  LYS A CE  1 
ATOM 417  N NZ  . LYS A 1 74  ? -4.688  -28.383 9.894  1.00 48.50 ? 76  LYS A NZ  1 
ATOM 418  N N   . GLN A 1 75  ? -7.265  -24.641 4.734  1.00 34.65 ? 77  GLN A N   1 
ATOM 419  C CA  . GLN A 1 75  ? -7.934  -25.340 3.648  1.00 36.88 ? 77  GLN A CA  1 
ATOM 420  C C   . GLN A 1 75  ? -8.475  -24.391 2.575  1.00 34.90 ? 77  GLN A C   1 
ATOM 421  O O   . GLN A 1 75  ? -9.362  -24.779 1.811  1.00 38.77 ? 77  GLN A O   1 
ATOM 422  C CB  . GLN A 1 75  ? -9.061  -26.192 4.231  1.00 34.70 ? 77  GLN A CB  1 
ATOM 423  C CG  . GLN A 1 75  ? -10.235 -25.337 4.704  1.00 49.24 ? 77  GLN A CG  1 
ATOM 424  C CD  . GLN A 1 75  ? -11.283 -26.127 5.475  1.00 61.14 ? 77  GLN A CD  1 
ATOM 425  O OE1 . GLN A 1 75  ? -11.056 -27.288 5.847  1.00 71.85 ? 77  GLN A OE1 1 
ATOM 426  N NE2 . GLN A 1 75  ? -12.451 -25.508 5.702  1.00 49.54 ? 77  GLN A NE2 1 
ATOM 427  N N   . MET A 1 76  ? -7.963  -23.164 2.498  1.00 34.71 ? 78  MET A N   1 
ATOM 428  C CA  . MET A 1 76  ? -8.370  -22.212 1.468  1.00 33.81 ? 78  MET A CA  1 
ATOM 429  C C   . MET A 1 76  ? -7.454  -22.314 0.249  1.00 37.96 ? 78  MET A C   1 
ATOM 430  O O   . MET A 1 76  ? -6.286  -22.705 0.360  1.00 45.08 ? 78  MET A O   1 
ATOM 431  C CB  . MET A 1 76  ? -8.324  -20.782 2.005  1.00 29.23 ? 78  MET A CB  1 
ATOM 432  C CG  . MET A 1 76  ? -9.462  -20.403 2.896  1.00 27.88 ? 78  MET A CG  1 
ATOM 433  S SD  . MET A 1 76  ? -9.460  -18.638 3.227  1.00 32.11 ? 78  MET A SD  1 
ATOM 434  C CE  . MET A 1 76  ? -10.093 -18.556 4.904  1.00 27.36 ? 78  MET A CE  1 
ATOM 435  N N   . SER A 1 77  ? -7.987  -21.956 -0.921 1.00 33.25 ? 79  SER A N   1 
ATOM 436  C CA  . SER A 1 77  ? -7.136  -21.807 -2.094 1.00 31.26 ? 79  SER A CA  1 
ATOM 437  C C   . SER A 1 77  ? -6.183  -20.652 -1.852 1.00 36.25 ? 79  SER A C   1 
ATOM 438  O O   . SER A 1 77  ? -6.565  -19.640 -1.255 1.00 38.73 ? 79  SER A O   1 
ATOM 439  C CB  . SER A 1 77  ? -7.960  -21.536 -3.349 1.00 39.13 ? 79  SER A CB  1 
ATOM 440  O OG  . SER A 1 77  ? -8.331  -20.169 -3.459 1.00 31.40 ? 79  SER A OG  1 
ATOM 441  N N   . HIS A 1 78  ? -4.939  -20.796 -2.323 1.00 41.22 ? 80  HIS A N   1 
ATOM 442  C CA  . HIS A 1 78  ? -3.886  -19.872 -1.900 1.00 37.46 ? 80  HIS A CA  1 
ATOM 443  C C   . HIS A 1 78  ? -4.274  -18.417 -2.129 1.00 32.02 ? 80  HIS A C   1 
ATOM 444  O O   . HIS A 1 78  ? -3.915  -17.549 -1.328 1.00 33.07 ? 80  HIS A O   1 
ATOM 445  C CB  . HIS A 1 78  ? -2.567  -20.195 -2.604 1.00 33.99 ? 80  HIS A CB  1 
ATOM 446  C CG  . HIS A 1 78  ? -1.933  -21.473 -2.144 1.00 44.97 ? 80  HIS A CG  1 
ATOM 447  N ND1 . HIS A 1 78  ? -0.736  -21.934 -2.648 1.00 50.12 ? 80  HIS A ND1 1 
ATOM 448  C CD2 . HIS A 1 78  ? -2.338  -22.398 -1.239 1.00 48.89 ? 80  HIS A CD2 1 
ATOM 449  C CE1 . HIS A 1 78  ? -0.420  -23.075 -2.061 1.00 51.92 ? 80  HIS A CE1 1 
ATOM 450  N NE2 . HIS A 1 78  ? -1.378  -23.381 -1.206 1.00 49.93 ? 80  HIS A NE2 1 
ATOM 451  N N   . ALA A 1 79  ? -5.041  -18.132 -3.182 1.00 29.05 ? 81  ALA A N   1 
ATOM 452  C CA  . ALA A 1 79  ? -5.501  -16.763 -3.374 1.00 28.63 ? 81  ALA A CA  1 
ATOM 453  C C   . ALA A 1 79  ? -6.505  -16.349 -2.310 1.00 33.97 ? 81  ALA A C   1 
ATOM 454  O O   . ALA A 1 79  ? -6.527  -15.178 -1.907 1.00 36.63 ? 81  ALA A O   1 
ATOM 455  C CB  . ALA A 1 79  ? -6.114  -16.589 -4.756 1.00 25.57 ? 81  ALA A CB  1 
ATOM 456  N N   . GLU A 1 80  ? -7.352  -17.277 -1.853 1.00 31.73 ? 82  GLU A N   1 
ATOM 457  C CA  . GLU A 1 80  ? -8.282  -16.931 -0.785 1.00 30.20 ? 82  GLU A CA  1 
ATOM 458  C C   . GLU A 1 80  ? -7.541  -16.714 0.528  1.00 33.01 ? 82  GLU A C   1 
ATOM 459  O O   . GLU A 1 80  ? -7.959  -15.892 1.347  1.00 33.77 ? 82  GLU A O   1 
ATOM 460  C CB  . GLU A 1 80  ? -9.331  -18.024 -0.618 1.00 31.93 ? 82  GLU A CB  1 
ATOM 461  C CG  . GLU A 1 80  ? -10.145 -18.309 -1.861 1.00 33.55 ? 82  GLU A CG  1 
ATOM 462  C CD  . GLU A 1 80  ? -10.923 -19.605 -1.731 1.00 38.34 ? 82  GLU A CD  1 
ATOM 463  O OE1 . GLU A 1 80  ? -10.310 -20.608 -1.315 1.00 41.60 ? 82  GLU A OE1 1 
ATOM 464  O OE2 . GLU A 1 80  ? -12.127 -19.644 -2.078 1.00 41.40 ? 82  GLU A OE2 1 
ATOM 465  N N   . GLN A 1 81  ? -6.447  -17.445 0.751  1.00 32.01 ? 83  GLN A N   1 
ATOM 466  C CA  . GLN A 1 81  ? -5.603  -17.170 1.907  1.00 28.26 ? 83  GLN A CA  1 
ATOM 467  C C   . GLN A 1 81  ? -5.054  -15.753 1.848  1.00 28.19 ? 83  GLN A C   1 
ATOM 468  O O   . GLN A 1 81  ? -5.156  -14.992 2.817  1.00 28.69 ? 83  GLN A O   1 
ATOM 469  C CB  . GLN A 1 81  ? -4.475  -18.190 1.970  1.00 28.02 ? 83  GLN A CB  1 
ATOM 470  C CG  . GLN A 1 81  ? -4.943  -19.594 2.258  1.00 31.18 ? 83  GLN A CG  1 
ATOM 471  C CD  . GLN A 1 81  ? -3.864  -20.647 2.035  1.00 37.09 ? 83  GLN A CD  1 
ATOM 472  O OE1 . GLN A 1 81  ? -2.910  -20.435 1.277  1.00 38.34 ? 83  GLN A OE1 1 
ATOM 473  N NE2 . GLN A 1 81  ? -3.986  -21.774 2.736  1.00 37.32 ? 83  GLN A NE2 1 
ATOM 474  N N   . LEU A 1 82  ? -4.468  -15.386 0.707  1.00 30.16 ? 84  LEU A N   1 
ATOM 475  C CA  . LEU A 1 82  ? -4.084  -14.000 0.447  1.00 33.31 ? 84  LEU A CA  1 
ATOM 476  C C   . LEU A 1 82  ? -5.207  -13.040 0.800  1.00 34.88 ? 84  LEU A C   1 
ATOM 477  O O   . LEU A 1 82  ? -5.015  -12.069 1.540  1.00 33.88 ? 84  LEU A O   1 
ATOM 478  C CB  . LEU A 1 82  ? -3.720  -13.838 -1.027 1.00 32.77 ? 84  LEU A CB  1 
ATOM 479  C CG  . LEU A 1 82  ? -2.242  -13.873 -1.356 1.00 33.43 ? 84  LEU A CG  1 
ATOM 480  C CD1 . LEU A 1 82  ? -2.090  -13.728 -2.841 1.00 34.34 ? 84  LEU A CD1 1 
ATOM 481  C CD2 . LEU A 1 82  ? -1.557  -12.728 -0.622 1.00 40.20 ? 84  LEU A CD2 1 
ATOM 482  N N   . GLN A 1 83  ? -6.387  -13.299 0.247  1.00 30.57 ? 85  GLN A N   1 
ATOM 483  C CA  . GLN A 1 83  ? -7.560  -12.494 0.531  1.00 31.36 ? 85  GLN A CA  1 
ATOM 484  C C   . GLN A 1 83  ? -7.758  -12.256 2.022  1.00 32.84 ? 85  GLN A C   1 
ATOM 485  O O   . GLN A 1 83  ? -7.943  -11.116 2.459  1.00 33.61 ? 85  GLN A O   1 
ATOM 486  C CB  . GLN A 1 83  ? -8.764  -13.190 -0.070 1.00 36.00 ? 85  GLN A CB  1 
ATOM 487  C CG  . GLN A 1 83  ? -9.996  -12.419 0.019  1.00 34.84 ? 85  GLN A CG  1 
ATOM 488  C CD  . GLN A 1 83  ? -11.062 -13.065 -0.791 1.00 44.32 ? 85  GLN A CD  1 
ATOM 489  O OE1 . GLN A 1 83  ? -11.542 -14.150 -0.456 1.00 50.32 ? 85  GLN A OE1 1 
ATOM 490  N NE2 . GLN A 1 83  ? -11.439 -12.416 -1.888 1.00 53.51 ? 85  GLN A NE2 1 
ATOM 491  N N   . VAL A 1 84  ? -7.715  -13.323 2.823  1.00 35.88 ? 86  VAL A N   1 
ATOM 492  C CA  . VAL A 1 84  ? -8.075  -13.184 4.232  1.00 34.12 ? 86  VAL A CA  1 
ATOM 493  C C   . VAL A 1 84  ? -6.912  -12.649 5.046  1.00 31.04 ? 86  VAL A C   1 
ATOM 494  O O   . VAL A 1 84  ? -7.122  -11.987 6.072  1.00 29.29 ? 86  VAL A O   1 
ATOM 495  C CB  . VAL A 1 84  ? -8.604  -14.513 4.806  1.00 34.09 ? 86  VAL A CB  1 
ATOM 496  C CG1 . VAL A 1 84  ? -9.652  -15.118 3.869  1.00 37.86 ? 86  VAL A CG1 1 
ATOM 497  C CG2 . VAL A 1 84  ? -7.468  -15.499 5.050  1.00 33.74 ? 86  VAL A CG2 1 
ATOM 498  N N   . MET A 1 85  ? -5.674  -12.907 4.623  1.00 31.30 ? 87  MET A N   1 
ATOM 499  C CA  . MET A 1 85  ? -4.564  -12.274 5.321  1.00 34.05 ? 87  MET A CA  1 
ATOM 500  C C   . MET A 1 85  ? -4.611  -10.768 5.118  1.00 31.46 ? 87  MET A C   1 
ATOM 501  O O   . MET A 1 85  ? -4.581  -10.002 6.086  1.00 31.16 ? 87  MET A O   1 
ATOM 502  C CB  . MET A 1 85  ? -3.224  -12.845 4.855  1.00 30.50 ? 87  MET A CB  1 
ATOM 503  C CG  . MET A 1 85  ? -3.073  -14.321 5.100  1.00 26.35 ? 87  MET A CG  1 
ATOM 504  S SD  . MET A 1 85  ? -3.338  -14.741 6.825  1.00 38.85 ? 87  MET A SD  1 
ATOM 505  C CE  . MET A 1 85  ? -2.194  -13.657 7.644  1.00 33.77 ? 87  MET A CE  1 
ATOM 506  N N   . ARG A 1 86  ? -4.731  -10.332 3.860  1.00 30.93 ? 88  ARG A N   1 
ATOM 507  C CA  . ARG A 1 86  ? -4.881  -8.911  3.569  1.00 29.40 ? 88  ARG A CA  1 
ATOM 508  C C   . ARG A 1 86  ? -6.057  -8.319  4.337  1.00 32.35 ? 88  ARG A C   1 
ATOM 509  O O   . ARG A 1 86  ? -5.970  -7.196  4.848  1.00 34.47 ? 88  ARG A O   1 
ATOM 510  C CB  . ARG A 1 86  ? -5.059  -8.702  2.063  1.00 30.33 ? 88  ARG A CB  1 
ATOM 511  C CG  . ARG A 1 86  ? -3.874  -9.204  1.227  1.00 38.33 ? 88  ARG A CG  1 
ATOM 512  C CD  . ARG A 1 86  ? -3.719  -8.450  -0.098 1.00 47.26 ? 88  ARG A CD  1 
ATOM 513  N NE  . ARG A 1 86  ? -3.591  -9.336  -1.252 1.00 44.98 ? 88  ARG A NE  1 
ATOM 514  C CZ  . ARG A 1 86  ? -2.599  -9.280  -2.133 1.00 42.28 ? 88  ARG A CZ  1 
ATOM 515  N NH1 . ARG A 1 86  ? -1.581  -8.450  -1.971 1.00 34.89 ? 88  ARG A NH1 1 
ATOM 516  N NH2 . ARG A 1 86  ? -2.624  -10.086 -3.196 1.00 37.67 ? 88  ARG A NH2 1 
ATOM 517  N N   . ASP A 1 87  ? -7.156  -9.074  4.456  1.00 30.50 ? 89  ASP A N   1 
ATOM 518  C CA  . ASP A 1 87  ? -8.315  -8.595  5.204  1.00 27.73 ? 89  ASP A CA  1 
ATOM 519  C C   . ASP A 1 87  ? -7.983  -8.340  6.669  1.00 30.46 ? 89  ASP A C   1 
ATOM 520  O O   . ASP A 1 87  ? -8.403  -7.324  7.238  1.00 29.21 ? 89  ASP A O   1 
ATOM 521  C CB  . ASP A 1 87  ? -9.449  -9.601  5.091  1.00 31.85 ? 89  ASP A CB  1 
ATOM 522  C CG  . ASP A 1 87  ? -10.235 -9.442  3.817  1.00 39.54 ? 89  ASP A CG  1 
ATOM 523  O OD1 . ASP A 1 87  ? -9.928  -8.496  3.043  1.00 35.12 ? 89  ASP A OD1 1 
ATOM 524  O OD2 . ASP A 1 87  ? -11.144 -10.280 3.590  1.00 42.28 ? 89  ASP A OD2 1 
ATOM 525  N N   . LEU A 1 88  ? -7.253  -9.266  7.301  1.00 34.78 ? 90  LEU A N   1 
ATOM 526  C CA  . LEU A 1 88  ? -6.855  -9.093  8.696  1.00 27.28 ? 90  LEU A CA  1 
ATOM 527  C C   . LEU A 1 88  ? -6.047  -7.821  8.880  1.00 28.32 ? 90  LEU A C   1 
ATOM 528  O O   . LEU A 1 88  ? -6.339  -7.011  9.764  1.00 33.13 ? 90  LEU A O   1 
ATOM 529  C CB  . LEU A 1 88  ? -6.033  -10.288 9.151  1.00 29.24 ? 90  LEU A CB  1 
ATOM 530  C CG  . LEU A 1 88  ? -6.788  -11.569 9.435  1.00 32.23 ? 90  LEU A CG  1 
ATOM 531  C CD1 . LEU A 1 88  ? -5.789  -12.636 9.794  1.00 31.19 ? 90  LEU A CD1 1 
ATOM 532  C CD2 . LEU A 1 88  ? -7.761  -11.328 10.567 1.00 32.02 ? 90  LEU A CD2 1 
ATOM 533  N N   . ALA A 1 89  ? -5.023  -7.632  8.041  1.00 27.87 ? 91  ALA A N   1 
ATOM 534  C CA  . ALA A 1 89  ? -4.128  -6.493  8.182  1.00 23.54 ? 91  ALA A CA  1 
ATOM 535  C C   . ALA A 1 89  ? -4.829  -5.190  7.875  1.00 24.61 ? 91  ALA A C   1 
ATOM 536  O O   . ALA A 1 89  ? -4.509  -4.161  8.477  1.00 28.28 ? 91  ALA A O   1 
ATOM 537  C CB  . ALA A 1 89  ? -2.933  -6.653  7.260  1.00 26.37 ? 91  ALA A CB  1 
ATOM 538  N N   . ALA A 1 90  ? -5.763  -5.208  6.935  1.00 26.74 ? 92  ALA A N   1 
ATOM 539  C CA  . ALA A 1 90  ? -6.548  -4.040  6.584  1.00 21.80 ? 92  ALA A CA  1 
ATOM 540  C C   . ALA A 1 90  ? -7.798  -3.890  7.443  1.00 25.41 ? 92  ALA A C   1 
ATOM 541  O O   . ALA A 1 90  ? -8.658  -3.072  7.117  1.00 28.47 ? 92  ALA A O   1 
ATOM 542  C CB  . ALA A 1 90  ? -6.930  -4.107  5.111  1.00 21.16 ? 92  ALA A CB  1 
ATOM 543  N N   . LYS A 1 91  ? -7.928  -4.676  8.515  1.00 26.06 ? 93  LYS A N   1 
ATOM 544  C CA  . LYS A 1 91  ? -9.046  -4.567  9.460  1.00 25.51 ? 93  LYS A CA  1 
ATOM 545  C C   . LYS A 1 91  ? -10.403 -4.616  8.763  1.00 25.02 ? 93  LYS A C   1 
ATOM 546  O O   . LYS A 1 91  ? -11.385 -4.048  9.246  1.00 25.03 ? 93  LYS A O   1 
ATOM 547  C CB  . LYS A 1 91  ? -8.939  -3.292  10.298 1.00 25.63 ? 93  LYS A CB  1 
ATOM 548  C CG  . LYS A 1 91  ? -7.798  -3.286  11.294 1.00 28.61 ? 93  LYS A CG  1 
ATOM 549  C CD  . LYS A 1 91  ? -8.154  -2.541  12.571 1.00 30.61 ? 93  LYS A CD  1 
ATOM 550  C CE  . LYS A 1 91  ? -9.452  -3.031  13.228 1.00 37.49 ? 93  LYS A CE  1 
ATOM 551  N NZ  . LYS A 1 91  ? -9.265  -3.958  14.401 1.00 36.21 ? 93  LYS A NZ  1 
ATOM 552  N N   . ASN A 1 92  ? -10.472 -5.289  7.621  1.00 26.66 ? 94  ASN A N   1 
ATOM 553  C CA  . ASN A 1 92  ? -11.698 -5.334  6.830  1.00 32.06 ? 94  ASN A CA  1 
ATOM 554  C C   . ASN A 1 92  ? -12.717 -6.260  7.495  1.00 28.64 ? 94  ASN A C   1 
ATOM 555  O O   . ASN A 1 92  ? -12.364 -7.349  7.949  1.00 30.09 ? 94  ASN A O   1 
ATOM 556  C CB  . ASN A 1 92  ? -11.362 -5.774  5.398  1.00 32.46 ? 94  ASN A CB  1 
ATOM 557  C CG  . ASN A 1 92  ? -12.562 -5.743  4.461  1.00 33.47 ? 94  ASN A CG  1 
ATOM 558  O OD1 . ASN A 1 92  ? -13.399 -4.840  4.524  1.00 37.10 ? 94  ASN A OD1 1 
ATOM 559  N ND2 . ASN A 1 92  ? -12.605 -6.696  3.533  1.00 33.51 ? 94  ASN A ND2 1 
ATOM 560  N N   . ASN A 1 93  ? -13.982 -5.822  7.561  1.00 29.20 ? 95  ASN A N   1 
ATOM 561  C CA  . ASN A 1 93  ? -15.022 -6.498  8.354  1.00 25.99 ? 95  ASN A CA  1 
ATOM 562  C C   . ASN A 1 93  ? -15.607 -7.699  7.607  1.00 26.32 ? 95  ASN A C   1 
ATOM 563  O O   . ASN A 1 93  ? -16.776 -7.730  7.228  1.00 21.77 ? 95  ASN A O   1 
ATOM 564  C CB  . ASN A 1 93  ? -16.131 -5.528  8.729  1.00 25.24 ? 95  ASN A CB  1 
ATOM 565  C CG  . ASN A 1 93  ? -16.923 -5.995  9.925  1.00 23.90 ? 95  ASN A CG  1 
ATOM 566  O OD1 . ASN A 1 93  ? -16.564 -6.967  10.575 1.00 28.21 ? 95  ASN A OD1 1 
ATOM 567  N ND2 . ASN A 1 93  ? -18.030 -5.334  10.194 1.00 23.43 ? 95  ASN A ND2 1 
ATOM 568  N N   . THR A 1 94  ? -14.767 -8.717  7.445  1.00 31.10 ? 96  THR A N   1 
ATOM 569  C CA  . THR A 1 94  ? -15.061 -9.998  6.817  1.00 27.90 ? 96  THR A CA  1 
ATOM 570  C C   . THR A 1 94  ? -15.338 -11.048 7.890  1.00 30.84 ? 96  THR A C   1 
ATOM 571  O O   . THR A 1 94  ? -15.036 -10.843 9.065  1.00 34.51 ? 96  THR A O   1 
ATOM 572  C CB  . THR A 1 94  ? -13.868 -10.388 5.932  1.00 34.04 ? 96  THR A CB  1 
ATOM 573  O OG1 . THR A 1 94  ? -13.802 -9.484  4.821  1.00 34.88 ? 96  THR A OG1 1 
ATOM 574  C CG2 . THR A 1 94  ? -13.897 -11.841 5.433  1.00 45.43 ? 96  THR A CG2 1 
ATOM 575  N N   . GLN A 1 95  ? -15.955 -12.163 7.488  1.00 28.11 ? 97  GLN A N   1 
ATOM 576  C CA  . GLN A 1 95  ? -16.157 -13.271 8.420  1.00 29.54 ? 97  GLN A CA  1 
ATOM 577  C C   . GLN A 1 95  ? -14.865 -13.651 9.151  1.00 35.00 ? 97  GLN A C   1 
ATOM 578  O O   . GLN A 1 95  ? -14.856 -13.792 10.380 1.00 35.12 ? 97  GLN A O   1 
ATOM 579  C CB  . GLN A 1 95  ? -16.737 -14.479 7.684  1.00 28.81 ? 97  GLN A CB  1 
ATOM 580  C CG  . GLN A 1 95  ? -16.915 -15.695 8.578  1.00 30.49 ? 97  GLN A CG  1 
ATOM 581  C CD  . GLN A 1 95  ? -15.814 -16.740 8.414  1.00 32.96 ? 97  GLN A CD  1 
ATOM 582  O OE1 . GLN A 1 95  ? -15.242 -16.904 7.330  1.00 34.27 ? 97  GLN A OE1 1 
ATOM 583  N NE2 . GLN A 1 95  ? -15.508 -17.448 9.498  1.00 33.87 ? 97  GLN A NE2 1 
ATOM 584  N N   . VAL A 1 96  ? -13.753 -13.801 8.416  1.00 36.85 ? 98  VAL A N   1 
ATOM 585  C CA  . VAL A 1 96  ? -12.505 -14.254 9.042  1.00 30.22 ? 98  VAL A CA  1 
ATOM 586  C C   . VAL A 1 96  ? -11.918 -13.193 9.968  1.00 31.05 ? 98  VAL A C   1 
ATOM 587  O O   . VAL A 1 96  ? -11.323 -13.524 11.002 1.00 30.10 ? 98  VAL A O   1 
ATOM 588  C CB  . VAL A 1 96  ? -11.507 -14.688 7.958  1.00 25.12 ? 98  VAL A CB  1 
ATOM 589  C CG1 . VAL A 1 96  ? -10.128 -14.835 8.523  1.00 24.09 ? 98  VAL A CG1 1 
ATOM 590  C CG2 . VAL A 1 96  ? -11.947 -16.005 7.408  1.00 31.33 ? 98  VAL A CG2 1 
ATOM 591  N N   . SER A 1 97  ? -12.079 -11.912 9.636  1.00 29.90 ? 99  SER A N   1 
ATOM 592  C CA  . SER A 1 97  ? -11.618 -10.869 10.542 1.00 27.64 ? 99  SER A CA  1 
ATOM 593  C C   . SER A 1 97  ? -12.426 -10.836 11.828 1.00 32.10 ? 99  SER A C   1 
ATOM 594  O O   . SER A 1 97  ? -11.889 -10.481 12.883 1.00 33.33 ? 99  SER A O   1 
ATOM 595  C CB  . SER A 1 97  ? -11.702 -9.519  9.869  1.00 26.04 ? 99  SER A CB  1 
ATOM 596  O OG  . SER A 1 97  ? -11.000 -9.549  8.655  1.00 33.62 ? 99  SER A OG  1 
ATOM 597  N N   . ARG A 1 98  ? -13.716 -11.177 11.762 1.00 31.71 ? 100 ARG A N   1 
ATOM 598  C CA  . ARG A 1 98  ? -14.538 -11.191 12.963 1.00 28.34 ? 100 ARG A CA  1 
ATOM 599  C C   . ARG A 1 98  ? -14.292 -12.449 13.777 1.00 30.42 ? 100 ARG A C   1 
ATOM 600  O O   . ARG A 1 98  ? -14.254 -12.393 15.009 1.00 35.69 ? 100 ARG A O   1 
ATOM 601  C CB  . ARG A 1 98  ? -16.013 -11.092 12.598 1.00 32.09 ? 100 ARG A CB  1 
ATOM 602  C CG  . ARG A 1 98  ? -16.323 -9.960  11.670 1.00 31.22 ? 100 ARG A CG  1 
ATOM 603  C CD  . ARG A 1 98  ? -17.790 -9.821  11.474 1.00 25.49 ? 100 ARG A CD  1 
ATOM 604  N NE  . ARG A 1 98  ? -18.270 -8.624  12.149 1.00 24.66 ? 100 ARG A NE  1 
ATOM 605  C CZ  . ARG A 1 98  ? -19.272 -8.617  13.012 1.00 30.77 ? 100 ARG A CZ  1 
ATOM 606  N NH1 . ARG A 1 98  ? -19.892 -9.733  13.346 1.00 28.83 ? 100 ARG A NH1 1 
ATOM 607  N NH2 . ARG A 1 98  ? -19.669 -7.460  13.546 1.00 43.85 ? 100 ARG A NH2 1 
ATOM 608  N N   . SER A 1 99  ? -14.142 -13.595 13.115 1.00 27.27 ? 101 SER A N   1 
ATOM 609  C CA  . SER A 1 99  ? -13.746 -14.790 13.845 1.00 30.01 ? 101 SER A CA  1 
ATOM 610  C C   . SER A 1 99  ? -12.413 -14.572 14.531 1.00 35.88 ? 101 SER A C   1 
ATOM 611  O O   . SER A 1 99  ? -12.226 -14.978 15.686 1.00 36.73 ? 101 SER A O   1 
ATOM 612  C CB  . SER A 1 99  ? -13.658 -15.985 12.905 1.00 31.24 ? 101 SER A CB  1 
ATOM 613  O OG  . SER A 1 99  ? -14.863 -16.124 12.184 1.00 41.17 ? 101 SER A OG  1 
ATOM 614  N N   . TYR A 1 100 ? -11.469 -13.934 13.826 1.00 33.71 ? 102 TYR A N   1 
ATOM 615  C CA  . TYR A 1 100 ? -10.166 -13.647 14.410 1.00 29.08 ? 102 TYR A CA  1 
ATOM 616  C C   . TYR A 1 100 ? -10.302 -12.609 15.511 1.00 31.52 ? 102 TYR A C   1 
ATOM 617  O O   . TYR A 1 100 ? -9.813  -12.803 16.631 1.00 35.85 ? 102 TYR A O   1 
ATOM 618  C CB  . TYR A 1 100 ? -9.192  -13.176 13.320 1.00 29.46 ? 102 TYR A CB  1 
ATOM 619  C CG  . TYR A 1 100 ? -7.870  -12.590 13.817 1.00 29.32 ? 102 TYR A CG  1 
ATOM 620  C CD1 . TYR A 1 100 ? -7.753  -11.239 14.123 1.00 28.53 ? 102 TYR A CD1 1 
ATOM 621  C CD2 . TYR A 1 100 ? -6.739  -13.390 13.958 1.00 24.95 ? 102 TYR A CD2 1 
ATOM 622  C CE1 . TYR A 1 100 ? -6.556  -10.711 14.573 1.00 31.57 ? 102 TYR A CE1 1 
ATOM 623  C CE2 . TYR A 1 100 ? -5.540  -12.874 14.405 1.00 23.76 ? 102 TYR A CE2 1 
ATOM 624  C CZ  . TYR A 1 100 ? -5.449  -11.530 14.713 1.00 31.55 ? 102 TYR A CZ  1 
ATOM 625  O OH  . TYR A 1 100 ? -4.256  -10.983 15.161 1.00 30.67 ? 102 TYR A OH  1 
ATOM 626  N N   . GLY A 1 101 ? -10.987 -11.507 15.220 1.00 30.22 ? 103 GLY A N   1 
ATOM 627  C CA  . GLY A 1 101 ? -11.081 -10.438 16.192 1.00 32.02 ? 103 GLY A CA  1 
ATOM 628  C C   . GLY A 1 101 ? -11.768 -10.836 17.476 1.00 29.45 ? 103 GLY A C   1 
ATOM 629  O O   . GLY A 1 101 ? -11.614 -10.143 18.487 1.00 31.57 ? 103 GLY A O   1 
ATOM 630  N N   . ILE A 1 102 ? -12.523 -11.940 17.460 1.00 27.47 ? 104 ILE A N   1 
ATOM 631  C CA  . ILE A 1 102 ? -13.286 -12.367 18.627 1.00 29.69 ? 104 ILE A CA  1 
ATOM 632  C C   . ILE A 1 102 ? -12.441 -13.217 19.565 1.00 31.49 ? 104 ILE A C   1 
ATOM 633  O O   . ILE A 1 102 ? -12.945 -13.685 20.595 1.00 33.34 ? 104 ILE A O   1 
ATOM 634  C CB  . ILE A 1 102 ? -14.578 -13.081 18.151 1.00 31.83 ? 104 ILE A CB  1 
ATOM 635  C CG1 . ILE A 1 102 ? -15.679 -12.994 19.181 1.00 30.83 ? 104 ILE A CG1 1 
ATOM 636  C CG2 . ILE A 1 102 ? -14.371 -14.552 17.798 1.00 34.99 ? 104 ILE A CG2 1 
ATOM 637  C CD1 . ILE A 1 102 ? -16.990 -13.388 18.591 1.00 40.35 ? 104 ILE A CD1 1 
ATOM 638  N N   . LEU A 1 103 ? -11.159 -13.404 19.251 1.00 28.47 ? 105 LEU A N   1 
ATOM 639  C CA  . LEU A 1 103 ? -10.244 -14.252 19.999 1.00 25.84 ? 105 LEU A CA  1 
ATOM 640  C C   . LEU A 1 103 ? -9.500  -13.395 21.017 1.00 31.92 ? 105 LEU A C   1 
ATOM 641  O O   . LEU A 1 103 ? -9.106  -12.264 20.711 1.00 35.37 ? 105 LEU A O   1 
ATOM 642  C CB  . LEU A 1 103 ? -9.233  -14.885 19.041 1.00 30.83 ? 105 LEU A CB  1 
ATOM 643  C CG  . LEU A 1 103 ? -9.596  -15.930 17.974 1.00 30.92 ? 105 LEU A CG  1 
ATOM 644  C CD1 . LEU A 1 103 ? -8.358  -16.217 17.132 1.00 29.77 ? 105 LEU A CD1 1 
ATOM 645  C CD2 . LEU A 1 103 ? -10.180 -17.220 18.523 1.00 31.53 ? 105 LEU A CD2 1 
ATOM 646  N N   . SER A 1 104 ? -9.284  -13.926 22.218 1.00 32.03 ? 106 SER A N   1 
ATOM 647  C CA  . SER A 1 104 ? -8.486  -13.184 23.192 1.00 36.20 ? 106 SER A CA  1 
ATOM 648  C C   . SER A 1 104 ? -7.107  -12.856 22.625 1.00 37.50 ? 106 SER A C   1 
ATOM 649  O O   . SER A 1 104 ? -6.532  -13.633 21.861 1.00 41.40 ? 106 SER A O   1 
ATOM 650  C CB  . SER A 1 104 ? -8.345  -13.987 24.477 1.00 41.85 ? 106 SER A CB  1 
ATOM 651  O OG  . SER A 1 104 ? -8.077  -15.342 24.183 1.00 41.56 ? 106 SER A OG  1 
ATOM 652  N N   . ASN A 1 105 ? -6.573  -11.684 22.995 1.00 37.00 ? 107 ASN A N   1 
ATOM 653  C CA  . ASN A 1 105 ? -5.300  -11.246 22.419 1.00 34.23 ? 107 ASN A CA  1 
ATOM 654  C C   . ASN A 1 105 ? -4.159  -12.217 22.673 1.00 41.28 ? 107 ASN A C   1 
ATOM 655  O O   . ASN A 1 105 ? -3.194  -12.212 21.905 1.00 47.18 ? 107 ASN A O   1 
ATOM 656  C CB  . ASN A 1 105 ? -4.879  -9.858  22.920 1.00 32.64 ? 107 ASN A CB  1 
ATOM 657  C CG  . ASN A 1 105 ? -5.801  -8.747  22.445 1.00 41.04 ? 107 ASN A CG  1 
ATOM 658  O OD1 . ASN A 1 105 ? -6.857  -8.998  21.865 1.00 55.26 ? 107 ASN A OD1 1 
ATOM 659  N ND2 . ASN A 1 105 ? -5.391  -7.506  22.672 1.00 39.38 ? 107 ASN A ND2 1 
ATOM 660  N N   . ASN A 1 106 ? -4.227  -13.033 23.729 1.00 46.19 ? 108 ASN A N   1 
ATOM 661  C CA  . ASN A 1 106 ? -3.235  -14.088 23.924 1.00 43.25 ? 108 ASN A CA  1 
ATOM 662  C C   . ASN A 1 106 ? -3.538  -15.335 23.113 1.00 43.47 ? 108 ASN A C   1 
ATOM 663  O O   . ASN A 1 106 ? -2.643  -16.169 22.950 1.00 50.41 ? 108 ASN A O   1 
ATOM 664  C CB  . ASN A 1 106 ? -3.112  -14.450 25.408 1.00 42.59 ? 108 ASN A CB  1 
ATOM 665  C CG  . ASN A 1 106 ? -2.652  -13.283 26.237 1.00 50.37 ? 108 ASN A CG  1 
ATOM 666  O OD1 . ASN A 1 106 ? -1.517  -12.833 26.093 1.00 60.63 ? 108 ASN A OD1 1 
ATOM 667  N ND2 . ASN A 1 106 ? -3.548  -12.728 27.049 1.00 50.69 ? 108 ASN A ND2 1 
ATOM 668  N N   . THR A 1 107 ? -4.767  -15.489 22.613 1.00 38.52 ? 109 THR A N   1 
ATOM 669  C CA  . THR A 1 107 ? -5.016  -16.507 21.602 1.00 39.37 ? 109 THR A CA  1 
ATOM 670  C C   . THR A 1 107 ? -4.562  -16.048 20.226 1.00 37.33 ? 109 THR A C   1 
ATOM 671  O O   . THR A 1 107 ? -4.099  -16.865 19.422 1.00 37.65 ? 109 THR A O   1 
ATOM 672  C CB  . THR A 1 107 ? -6.490  -16.868 21.554 1.00 39.10 ? 109 THR A CB  1 
ATOM 673  O OG1 . THR A 1 107 ? -6.967  -17.032 22.885 1.00 51.60 ? 109 THR A OG1 1 
ATOM 674  C CG2 . THR A 1 107 ? -6.659  -18.167 20.834 1.00 38.29 ? 109 THR A CG2 1 
ATOM 675  N N   . LYS A 1 108 ? -4.682  -14.752 19.940 1.00 36.06 ? 110 LYS A N   1 
ATOM 676  C CA  . LYS A 1 108 ? -4.092  -14.216 18.724 1.00 34.79 ? 110 LYS A CA  1 
ATOM 677  C C   . LYS A 1 108 ? -2.610  -14.557 18.645 1.00 36.26 ? 110 LYS A C   1 
ATOM 678  O O   . LYS A 1 108 ? -2.071  -14.742 17.547 1.00 35.82 ? 110 LYS A O   1 
ATOM 679  C CB  . LYS A 1 108 ? -4.322  -12.706 18.669 1.00 29.71 ? 110 LYS A CB  1 
ATOM 680  C CG  . LYS A 1 108 ? -5.769  -12.354 18.366 1.00 31.39 ? 110 LYS A CG  1 
ATOM 681  C CD  . LYS A 1 108 ? -6.049  -10.875 18.468 1.00 29.16 ? 110 LYS A CD  1 
ATOM 682  C CE  . LYS A 1 108 ? -7.543  -10.638 18.495 1.00 29.45 ? 110 LYS A CE  1 
ATOM 683  N NZ  . LYS A 1 108 ? -7.903  -9.414  19.260 1.00 30.20 ? 110 LYS A NZ  1 
ATOM 684  N N   . LEU A 1 109 ? -1.945  -14.678 19.802 1.00 39.68 ? 111 LEU A N   1 
ATOM 685  C CA  . LEU A 1 109 ? -0.532  -15.045 19.825 1.00 36.47 ? 111 LEU A CA  1 
ATOM 686  C C   . LEU A 1 109 ? -0.347  -16.478 19.363 1.00 33.93 ? 111 LEU A C   1 
ATOM 687  O O   . LEU A 1 109 ? 0.454   -16.751 18.467 1.00 34.61 ? 111 LEU A O   1 
ATOM 688  C CB  . LEU A 1 109 ? 0.041   -14.861 21.228 1.00 36.06 ? 111 LEU A CB  1 
ATOM 689  C CG  . LEU A 1 109 ? 0.273   -13.422 21.670 1.00 32.74 ? 111 LEU A CG  1 
ATOM 690  C CD1 . LEU A 1 109 ? 0.978   -13.369 23.007 1.00 39.17 ? 111 LEU A CD1 1 
ATOM 691  C CD2 . LEU A 1 109 ? 1.056   -12.679 20.617 1.00 32.23 ? 111 LEU A CD2 1 
ATOM 692  N N   . ALA A 1 110 ? -1.090  -17.409 19.958 1.00 33.07 ? 112 ALA A N   1 
ATOM 693  C CA  . ALA A 1 110 ? -0.962  -18.803 19.559 1.00 35.25 ? 112 ALA A CA  1 
ATOM 694  C C   . ALA A 1 110 ? -1.422  -19.005 18.123 1.00 33.42 ? 112 ALA A C   1 
ATOM 695  O O   . ALA A 1 110 ? -0.836  -19.803 17.382 1.00 34.29 ? 112 ALA A O   1 
ATOM 696  C CB  . ALA A 1 110 ? -1.751  -19.696 20.510 1.00 34.86 ? 112 ALA A CB  1 
ATOM 697  N N   . PHE A 1 111 ? -2.466  -18.281 17.714 1.00 34.61 ? 113 PHE A N   1 
ATOM 698  C CA  . PHE A 1 111 ? -2.940  -18.368 16.335 1.00 35.44 ? 113 PHE A CA  1 
ATOM 699  C C   . PHE A 1 111 ? -1.836  -17.979 15.361 1.00 36.76 ? 113 PHE A C   1 
ATOM 700  O O   . PHE A 1 111 ? -1.546  -18.704 14.400 1.00 34.05 ? 113 PHE A O   1 
ATOM 701  C CB  . PHE A 1 111 ? -4.164  -17.466 16.143 1.00 30.72 ? 113 PHE A CB  1 
ATOM 702  C CG  . PHE A 1 111 ? -4.489  -17.189 14.709 1.00 29.23 ? 113 PHE A CG  1 
ATOM 703  C CD1 . PHE A 1 111 ? -3.917  -16.109 14.042 1.00 31.18 ? 113 PHE A CD1 1 
ATOM 704  C CD2 . PHE A 1 111 ? -5.370  -18.006 14.022 1.00 30.44 ? 113 PHE A CD2 1 
ATOM 705  C CE1 . PHE A 1 111 ? -4.214  -15.857 12.714 1.00 29.93 ? 113 PHE A CE1 1 
ATOM 706  C CE2 . PHE A 1 111 ? -5.676  -17.762 12.694 1.00 30.94 ? 113 PHE A CE2 1 
ATOM 707  C CZ  . PHE A 1 111 ? -5.102  -16.681 12.040 1.00 30.71 ? 113 PHE A CZ  1 
ATOM 708  N N   . TRP A 1 112 ? -1.215  -16.822 15.590 1.00 35.18 ? 114 TRP A N   1 
ATOM 709  C CA  . TRP A 1 112 ? -0.181  -16.363 14.679 1.00 31.66 ? 114 TRP A CA  1 
ATOM 710  C C   . TRP A 1 112 ? 1.013   -17.307 14.679 1.00 37.55 ? 114 TRP A C   1 
ATOM 711  O O   . TRP A 1 112 ? 1.639   -17.525 13.634 1.00 39.53 ? 114 TRP A O   1 
ATOM 712  C CB  . TRP A 1 112 ? 0.233   -14.947 15.040 1.00 25.59 ? 114 TRP A CB  1 
ATOM 713  C CG  . TRP A 1 112 ? -0.562  -13.955 14.289 1.00 27.95 ? 114 TRP A CG  1 
ATOM 714  C CD1 . TRP A 1 112 ? -1.653  -13.266 14.732 1.00 30.26 ? 114 TRP A CD1 1 
ATOM 715  C CD2 . TRP A 1 112 ? -0.354  -13.550 12.936 1.00 28.15 ? 114 TRP A CD2 1 
ATOM 716  N NE1 . TRP A 1 112 ? -2.123  -12.434 13.745 1.00 26.32 ? 114 TRP A NE1 1 
ATOM 717  C CE2 . TRP A 1 112 ? -1.344  -12.590 12.630 1.00 26.33 ? 114 TRP A CE2 1 
ATOM 718  C CE3 . TRP A 1 112 ? 0.583   -13.893 11.954 1.00 27.55 ? 114 TRP A CE3 1 
ATOM 719  C CZ2 . TRP A 1 112 ? -1.426  -11.976 11.387 1.00 26.98 ? 114 TRP A CZ2 1 
ATOM 720  C CZ3 . TRP A 1 112 ? 0.499   -13.283 10.715 1.00 26.24 ? 114 TRP A CZ3 1 
ATOM 721  C CH2 . TRP A 1 112 ? -0.500  -12.339 10.443 1.00 29.22 ? 114 TRP A CH2 1 
ATOM 722  N N   . TYR A 1 113 ? 1.339   -17.892 15.834 1.00 39.73 ? 115 TYR A N   1 
ATOM 723  C CA  . TYR A 1 113 ? 2.431   -18.857 15.863 1.00 37.27 ? 115 TYR A CA  1 
ATOM 724  C C   . TYR A 1 113 ? 2.147   -19.994 14.898 1.00 37.37 ? 115 TYR A C   1 
ATOM 725  O O   . TYR A 1 113 ? 2.910   -20.228 13.954 1.00 37.31 ? 115 TYR A O   1 
ATOM 726  C CB  . TYR A 1 113 ? 2.655   -19.390 17.276 1.00 37.76 ? 115 TYR A CB  1 
ATOM 727  C CG  . TYR A 1 113 ? 3.359   -20.715 17.256 1.00 41.92 ? 115 TYR A CG  1 
ATOM 728  C CD1 . TYR A 1 113 ? 4.660   -20.821 16.773 1.00 44.27 ? 115 TYR A CD1 1 
ATOM 729  C CD2 . TYR A 1 113 ? 2.721   -21.869 17.692 1.00 43.88 ? 115 TYR A CD2 1 
ATOM 730  C CE1 . TYR A 1 113 ? 5.306   -22.043 16.734 1.00 43.36 ? 115 TYR A CE1 1 
ATOM 731  C CE2 . TYR A 1 113 ? 3.359   -23.092 17.666 1.00 42.92 ? 115 TYR A CE2 1 
ATOM 732  C CZ  . TYR A 1 113 ? 4.647   -23.172 17.184 1.00 45.46 ? 115 TYR A CZ  1 
ATOM 733  O OH  . TYR A 1 113 ? 5.277   -24.387 17.146 1.00 58.23 ? 115 TYR A OH  1 
ATOM 734  N N   . GLU A 1 114 ? 1.016   -20.680 15.095 1.00 35.42 ? 116 GLU A N   1 
ATOM 735  C CA  . GLU A 1 114 ? 0.633   -21.760 14.194 1.00 34.48 ? 116 GLU A CA  1 
ATOM 736  C C   . GLU A 1 114 ? 0.493   -21.281 12.760 1.00 35.22 ? 116 GLU A C   1 
ATOM 737  O O   . GLU A 1 114 ? 0.922   -21.975 11.836 1.00 42.22 ? 116 GLU A O   1 
ATOM 738  C CB  . GLU A 1 114 ? -0.664  -22.402 14.657 1.00 40.87 ? 116 GLU A CB  1 
ATOM 739  C CG  . GLU A 1 114 ? -0.666  -22.738 16.114 1.00 45.06 ? 116 GLU A CG  1 
ATOM 740  C CD  . GLU A 1 114 ? -0.133  -24.131 16.344 1.00 62.54 ? 116 GLU A CD  1 
ATOM 741  O OE1 . GLU A 1 114 ? 0.720   -24.589 15.536 1.00 64.60 ? 116 GLU A OE1 1 
ATOM 742  O OE2 . GLU A 1 114 ? -0.556  -24.763 17.334 1.00 64.48 ? 116 GLU A OE2 1 
ATOM 743  N N   . LEU A 1 115 ? -0.116  -20.112 12.542 1.00 33.51 ? 117 LEU A N   1 
ATOM 744  C CA  . LEU A 1 115 ? -0.153  -19.564 11.185 1.00 33.83 ? 117 LEU A CA  1 
ATOM 745  C C   . LEU A 1 115 ? 1.232   -19.494 10.575 1.00 35.39 ? 117 LEU A C   1 
ATOM 746  O O   . LEU A 1 115 ? 1.418   -19.827 9.399  1.00 35.85 ? 117 LEU A O   1 
ATOM 747  C CB  . LEU A 1 115 ? -0.782  -18.174 11.156 1.00 33.27 ? 117 LEU A CB  1 
ATOM 748  C CG  . LEU A 1 115 ? -1.256  -17.780 9.751  1.00 29.22 ? 117 LEU A CG  1 
ATOM 749  C CD1 . LEU A 1 115 ? -2.067  -18.875 9.109  1.00 30.38 ? 117 LEU A CD1 1 
ATOM 750  C CD2 . LEU A 1 115 ? -2.047  -16.492 9.790  1.00 32.90 ? 117 LEU A CD2 1 
ATOM 751  N N   . SER A 1 116 ? 2.218   -19.053 11.359 1.00 36.56 ? 118 SER A N   1 
ATOM 752  C CA  . SER A 1 116 ? 3.578   -18.974 10.845 1.00 36.81 ? 118 SER A CA  1 
ATOM 753  C C   . SER A 1 116 ? 4.103   -20.357 10.484 1.00 35.89 ? 118 SER A C   1 
ATOM 754  O O   . SER A 1 116 ? 4.775   -20.523 9.463  1.00 40.73 ? 118 SER A O   1 
ATOM 755  C CB  . SER A 1 116 ? 4.482   -18.282 11.866 1.00 38.04 ? 118 SER A CB  1 
ATOM 756  O OG  . SER A 1 116 ? 5.203   -19.216 12.651 1.00 42.23 ? 118 SER A OG  1 
ATOM 757  N N   . GLU A 1 117 ? 3.773   -21.371 11.284 1.00 33.46 ? 119 GLU A N   1 
ATOM 758  C CA  . GLU A 1 117 ? 4.224   -22.724 10.976 1.00 36.14 ? 119 GLU A CA  1 
ATOM 759  C C   . GLU A 1 117 ? 3.575   -23.254 9.699  1.00 37.70 ? 119 GLU A C   1 
ATOM 760  O O   . GLU A 1 117 ? 4.226   -23.943 8.908  1.00 38.25 ? 119 GLU A O   1 
ATOM 761  C CB  . GLU A 1 117 ? 3.926   -23.651 12.149 1.00 40.69 ? 119 GLU A CB  1 
ATOM 762  C CG  . GLU A 1 117 ? 4.669   -23.305 13.426 1.00 47.43 ? 119 GLU A CG  1 
ATOM 763  C CD  . GLU A 1 117 ? 6.009   -23.998 13.513 1.00 54.09 ? 119 GLU A CD  1 
ATOM 764  O OE1 . GLU A 1 117 ? 6.055   -25.193 13.157 1.00 64.08 ? 119 GLU A OE1 1 
ATOM 765  O OE2 . GLU A 1 117 ? 7.006   -23.365 13.943 1.00 54.01 ? 119 GLU A OE2 1 
ATOM 766  N N   . LEU A 1 118 ? 2.288   -22.966 9.491  1.00 38.32 ? 120 LEU A N   1 
ATOM 767  C CA  . LEU A 1 118 ? 1.626   -23.367 8.252  1.00 34.39 ? 120 LEU A CA  1 
ATOM 768  C C   . LEU A 1 118 ? 2.204   -22.622 7.066  1.00 40.06 ? 120 LEU A C   1 
ATOM 769  O O   . LEU A 1 118 ? 2.349   -23.186 5.972  1.00 38.85 ? 120 LEU A O   1 
ATOM 770  C CB  . LEU A 1 118 ? 0.133   -23.095 8.346  1.00 28.83 ? 120 LEU A CB  1 
ATOM 771  C CG  . LEU A 1 118 ? -0.613  -24.085 9.206  1.00 24.95 ? 120 LEU A CG  1 
ATOM 772  C CD1 . LEU A 1 118 ? -1.899  -23.448 9.641  1.00 29.85 ? 120 LEU A CD1 1 
ATOM 773  C CD2 . LEU A 1 118 ? -0.867  -25.326 8.395  1.00 30.41 ? 120 LEU A CD2 1 
ATOM 774  N N   . MET A 1 119 ? 2.498   -21.335 7.258  1.00 39.39 ? 121 MET A N   1 
ATOM 775  C CA  . MET A 1 119 ? 3.153   -20.564 6.217  1.00 33.78 ? 121 MET A CA  1 
ATOM 776  C C   . MET A 1 119 ? 4.515   -21.146 5.913  1.00 36.39 ? 121 MET A C   1 
ATOM 777  O O   . MET A 1 119 ? 4.917   -21.247 4.752  1.00 44.60 ? 121 MET A O   1 
ATOM 778  C CB  . MET A 1 119 ? 3.291   -19.121 6.665  1.00 30.65 ? 121 MET A CB  1 
ATOM 779  C CG  . MET A 1 119 ? 2.000   -18.411 6.740  1.00 36.65 ? 121 MET A CG  1 
ATOM 780  S SD  . MET A 1 119 ? 2.190   -16.750 7.379  1.00 35.75 ? 121 MET A SD  1 
ATOM 781  C CE  . MET A 1 119 ? 0.563   -16.090 6.982  1.00 33.04 ? 121 MET A CE  1 
ATOM 782  N N   . VAL A 1 120 ? 5.232   -21.554 6.949  1.00 33.74 ? 122 VAL A N   1 
ATOM 783  C CA  . VAL A 1 120 ? 6.606   -21.963 6.750  1.00 35.05 ? 122 VAL A CA  1 
ATOM 784  C C   . VAL A 1 120 ? 6.629   -23.325 6.060  1.00 41.64 ? 122 VAL A C   1 
ATOM 785  O O   . VAL A 1 120 ? 7.344   -23.521 5.073  1.00 47.15 ? 122 VAL A O   1 
ATOM 786  C CB  . VAL A 1 120 ? 7.344   -21.942 8.110  1.00 43.25 ? 122 VAL A CB  1 
ATOM 787  C CG1 . VAL A 1 120 ? 7.192   -23.255 8.943  1.00 41.74 ? 122 VAL A CG1 1 
ATOM 788  C CG2 . VAL A 1 120 ? 8.759   -21.417 8.002  1.00 45.54 ? 122 VAL A CG2 1 
ATOM 789  N N   . LYS A 1 121 ? 5.774   -24.256 6.507  1.00 40.92 ? 123 LYS A N   1 
ATOM 790  C CA  . LYS A 1 121 ? 5.625   -25.580 5.910  1.00 36.55 ? 123 LYS A CA  1 
ATOM 791  C C   . LYS A 1 121 ? 4.914   -25.544 4.568  1.00 38.61 ? 123 LYS A C   1 
ATOM 792  O O   . LYS A 1 121 ? 4.750   -26.604 3.957  1.00 46.43 ? 123 LYS A O   1 
ATOM 793  C CB  . LYS A 1 121 ? 4.853   -26.510 6.854  1.00 35.08 ? 123 LYS A CB  1 
ATOM 794  C CG  . LYS A 1 121 ? 5.457   -26.635 8.244  1.00 44.28 ? 123 LYS A CG  1 
ATOM 795  C CD  . LYS A 1 121 ? 4.546   -27.391 9.226  1.00 45.13 ? 123 LYS A CD  1 
ATOM 796  C CE  . LYS A 1 121 ? 4.992   -28.835 9.441  1.00 57.18 ? 123 LYS A CE  1 
ATOM 797  N NZ  . LYS A 1 121 ? 3.897   -29.739 9.928  1.00 59.19 ? 123 LYS A NZ  1 
ATOM 798  N N   . GLY A 1 122 ? 4.443   -24.382 4.117  1.00 37.39 ? 124 GLY A N   1 
ATOM 799  C CA  . GLY A 1 122 ? 3.884   -24.251 2.786  1.00 41.82 ? 124 GLY A CA  1 
ATOM 800  C C   . GLY A 1 122 ? 2.385   -24.437 2.644  1.00 42.02 ? 124 GLY A C   1 
ATOM 801  O O   . GLY A 1 122 ? 1.882   -24.402 1.510  1.00 40.21 ? 124 GLY A O   1 
ATOM 802  N N   . PHE A 1 123 ? 1.649   -24.625 3.741  1.00 42.03 ? 125 PHE A N   1 
ATOM 803  C CA  . PHE A 1 123 ? 0.204   -24.787 3.639  1.00 37.04 ? 125 PHE A CA  1 
ATOM 804  C C   . PHE A 1 123 ? -0.529  -23.463 3.530  1.00 33.62 ? 125 PHE A C   1 
ATOM 805  O O   . PHE A 1 123 ? -1.712  -23.460 3.182  1.00 35.18 ? 125 PHE A O   1 
ATOM 806  C CB  . PHE A 1 123 ? -0.359  -25.545 4.844  1.00 40.67 ? 125 PHE A CB  1 
ATOM 807  C CG  . PHE A 1 123 ? 0.257   -26.900 5.078  1.00 42.26 ? 125 PHE A CG  1 
ATOM 808  C CD1 . PHE A 1 123 ? 1.468   -27.028 5.751  1.00 44.34 ? 125 PHE A CD1 1 
ATOM 809  C CD2 . PHE A 1 123 ? -0.411  -28.051 4.688  1.00 39.86 ? 125 PHE A CD2 1 
ATOM 810  C CE1 . PHE A 1 123 ? 2.019   -28.277 5.992  1.00 47.90 ? 125 PHE A CE1 1 
ATOM 811  C CE2 . PHE A 1 123 ? 0.132   -29.299 4.924  1.00 42.46 ? 125 PHE A CE2 1 
ATOM 812  C CZ  . PHE A 1 123 ? 1.347   -29.415 5.578  1.00 49.14 ? 125 PHE A CZ  1 
ATOM 813  N N   . VAL A 1 124 ? 0.121   -22.348 3.851  1.00 32.68 ? 126 VAL A N   1 
ATOM 814  C CA  . VAL A 1 124 ? -0.526  -21.041 3.826  1.00 35.05 ? 126 VAL A CA  1 
ATOM 815  C C   . VAL A 1 124 ? 0.443   -20.046 3.204  1.00 37.00 ? 126 VAL A C   1 
ATOM 816  O O   . VAL A 1 124 ? 1.663   -20.137 3.379  1.00 37.69 ? 126 VAL A O   1 
ATOM 817  C CB  . VAL A 1 124 ? -0.980  -20.579 5.240  1.00 33.88 ? 126 VAL A CB  1 
ATOM 818  C CG1 . VAL A 1 124 ? -1.605  -19.194 5.203  1.00 31.10 ? 126 VAL A CG1 1 
ATOM 819  C CG2 . VAL A 1 124 ? -1.971  -21.553 5.825  1.00 33.35 ? 126 VAL A CG2 1 
ATOM 820  N N   . VAL A 1 125 ? -0.117  -19.090 2.473  1.00 36.36 ? 127 VAL A N   1 
ATOM 821  C CA  . VAL A 1 125 ? 0.647   -18.191 1.620  1.00 35.23 ? 127 VAL A CA  1 
ATOM 822  C C   . VAL A 1 125 ? 0.318   -16.757 2.013  1.00 37.02 ? 127 VAL A C   1 
ATOM 823  O O   . VAL A 1 125 ? -0.691  -16.200 1.576  1.00 37.05 ? 127 VAL A O   1 
ATOM 824  C CB  . VAL A 1 125 ? 0.329   -18.447 0.137  1.00 33.62 ? 127 VAL A CB  1 
ATOM 825  C CG1 . VAL A 1 125 ? 0.754   -17.284 -0.741 1.00 35.42 ? 127 VAL A CG1 1 
ATOM 826  C CG2 . VAL A 1 125 ? 0.969   -19.743 -0.319 1.00 33.41 ? 127 VAL A CG2 1 
ATOM 827  N N   . PRO A 1 126 ? 1.166   -16.079 2.825  1.00 38.48 ? 128 PRO A N   1 
ATOM 828  C CA  . PRO A 1 126 ? 0.979   -14.655 3.072  1.00 36.11 ? 128 PRO A CA  1 
ATOM 829  C C   . PRO A 1 126 ? 1.699   -13.973 1.903  1.00 42.41 ? 128 PRO A C   1 
ATOM 830  O O   . PRO A 1 126 ? 2.657   -14.553 1.424  1.00 52.08 ? 128 PRO A O   1 
ATOM 831  C CB  . PRO A 1 126 ? 1.747   -14.404 4.369  1.00 35.38 ? 128 PRO A CB  1 
ATOM 832  C CG  . PRO A 1 126 ? 2.878   -15.408 4.315  1.00 29.64 ? 128 PRO A CG  1 
ATOM 833  C CD  . PRO A 1 126 ? 2.297   -16.616 3.606  1.00 31.92 ? 128 PRO A CD  1 
ATOM 834  N N   . VAL A 1 127 ? 1.222   -12.809 1.453  1.00 31.80 ? 129 VAL A N   1 
ATOM 835  C CA  . VAL A 1 127 ? 1.888   -12.032 0.356  1.00 36.45 ? 129 VAL A CA  1 
ATOM 836  C C   . VAL A 1 127 ? 1.848   -12.798 -0.979 1.00 36.94 ? 129 VAL A C   1 
ATOM 837  O O   . VAL A 1 127 ? 1.691   -14.034 -0.967 1.00 30.60 ? 129 VAL A O   1 
ATOM 838  C CB  . VAL A 1 127 ? 3.321   -11.589 0.731  1.00 30.07 ? 129 VAL A CB  1 
ATOM 839  C CG1 . VAL A 1 127 ? 3.468   -11.277 2.213  1.00 34.44 ? 129 VAL A CG1 1 
ATOM 840  C CG2 . VAL A 1 127 ? 4.386   -12.569 0.264  1.00 18.80 ? 129 VAL A CG2 1 
ATOM 841  N N   . PRO A 1 128 ? 1.948   -12.103 -2.134 1.00 34.86 ? 130 PRO A N   1 
ATOM 842  C CA  . PRO A 1 128 ? 1.902   -12.721 -3.461 1.00 29.87 ? 130 PRO A CA  1 
ATOM 843  C C   . PRO A 1 128 ? 3.103   -13.572 -3.794 1.00 41.44 ? 130 PRO A C   1 
ATOM 844  O O   . PRO A 1 128 ? 4.095   -13.622 -3.057 1.00 47.10 ? 130 PRO A O   1 
ATOM 845  C CB  . PRO A 1 128 ? 1.841   -11.520 -4.404 1.00 34.34 ? 130 PRO A CB  1 
ATOM 846  C CG  . PRO A 1 128 ? 1.448   -10.398 -3.557 1.00 44.78 ? 130 PRO A CG  1 
ATOM 847  C CD  . PRO A 1 128 ? 2.028   -10.644 -2.230 1.00 41.23 ? 130 PRO A CD  1 
ATOM 848  N N   . THR A 1 129 ? 3.019   -14.231 -4.941 1.00 47.02 ? 131 THR A N   1 
ATOM 849  C CA  . THR A 1 129 ? 4.059   -15.153 -5.362 1.00 55.19 ? 131 THR A CA  1 
ATOM 850  C C   . THR A 1 129 ? 5.242   -14.438 -6.005 1.00 50.96 ? 131 THR A C   1 
ATOM 851  O O   . THR A 1 129 ? 6.207   -15.099 -6.402 1.00 58.04 ? 131 THR A O   1 
ATOM 852  C CB  . THR A 1 129 ? 3.456   -16.194 -6.315 1.00 55.81 ? 131 THR A CB  1 
ATOM 853  O OG1 . THR A 1 129 ? 4.322   -17.336 -6.408 1.00 47.74 ? 131 THR A OG1 1 
ATOM 854  C CG2 . THR A 1 129 ? 3.231   -15.580 -7.700 1.00 50.82 ? 131 THR A CG2 1 
ATOM 855  N N   . ASP A 1 130 ? 5.200   -13.108 -6.096 1.00 47.05 ? 132 ASP A N   1 
ATOM 856  C CA  . ASP A 1 130 ? 6.298   -12.325 -6.643 1.00 43.39 ? 132 ASP A CA  1 
ATOM 857  C C   . ASP A 1 130 ? 6.816   -11.322 -5.620 1.00 46.49 ? 132 ASP A C   1 
ATOM 858  O O   . ASP A 1 130 ? 7.493   -10.362 -5.988 1.00 46.28 ? 132 ASP A O   1 
ATOM 859  C CB  . ASP A 1 130 ? 5.848   -11.589 -7.904 1.00 53.41 ? 132 ASP A CB  1 
ATOM 860  C CG  . ASP A 1 130 ? 4.869   -10.445 -7.605 1.00 66.86 ? 132 ASP A CG  1 
ATOM 861  O OD1 . ASP A 1 130 ? 3.844   -10.677 -6.918 1.00 58.28 ? 132 ASP A OD1 1 
ATOM 862  O OD2 . ASP A 1 130 ? 5.119   -9.311  -8.096 1.00 73.48 ? 132 ASP A OD2 1 
ATOM 863  N N   . TYR A 1 131 ? 6.492   -11.515 -4.342 1.00 52.56 ? 133 TYR A N   1 
ATOM 864  C CA  . TYR A 1 131 ? 6.705   -10.477 -3.341 1.00 46.88 ? 133 TYR A CA  1 
ATOM 865  C C   . TYR A 1 131 ? 8.175   -10.396 -2.943 1.00 39.22 ? 133 TYR A C   1 
ATOM 866  O O   . TYR A 1 131 ? 8.854   -11.415 -2.795 1.00 41.64 ? 133 TYR A O   1 
ATOM 867  C CB  . TYR A 1 131 ? 5.835   -10.733 -2.096 1.00 38.85 ? 133 TYR A CB  1 
ATOM 868  C CG  . TYR A 1 131 ? 6.171   -9.820  -0.937 1.00 30.39 ? 133 TYR A CG  1 
ATOM 869  C CD1 . TYR A 1 131 ? 5.556   -8.588  -0.802 1.00 30.65 ? 133 TYR A CD1 1 
ATOM 870  C CD2 . TYR A 1 131 ? 7.123   -10.180 0.001  1.00 28.58 ? 133 TYR A CD2 1 
ATOM 871  C CE1 . TYR A 1 131 ? 5.880   -7.736  0.234  1.00 33.50 ? 133 TYR A CE1 1 
ATOM 872  C CE2 . TYR A 1 131 ? 7.456   -9.343  1.030  1.00 29.64 ? 133 TYR A CE2 1 
ATOM 873  C CZ  . TYR A 1 131 ? 6.833   -8.120  1.151  1.00 33.93 ? 133 TYR A CZ  1 
ATOM 874  O OH  . TYR A 1 131 ? 7.169   -7.272  2.188  1.00 34.50 ? 133 TYR A OH  1 
ATOM 875  N N   . LYS A 1 132 ? 8.661   -9.169  -2.780 1.00 32.90 ? 134 LYS A N   1 
ATOM 876  C CA  . LYS A 1 132 ? 9.945   -8.889  -2.157 1.00 31.29 ? 134 LYS A CA  1 
ATOM 877  C C   . LYS A 1 132 ? 9.717   -7.801  -1.123 1.00 38.03 ? 134 LYS A C   1 
ATOM 878  O O   . LYS A 1 132 ? 9.069   -6.793  -1.425 1.00 43.22 ? 134 LYS A O   1 
ATOM 879  C CB  . LYS A 1 132 ? 10.982  -8.419  -3.175 1.00 35.80 ? 134 LYS A CB  1 
ATOM 880  C CG  . LYS A 1 132 ? 11.651  -9.535  -3.952 1.00 56.85 ? 134 LYS A CG  1 
ATOM 881  C CD  . LYS A 1 132 ? 12.388  -10.511 -3.036 1.00 66.89 ? 134 LYS A CD  1 
ATOM 882  C CE  . LYS A 1 132 ? 13.777  -10.846 -3.573 1.00 68.66 ? 134 LYS A CE  1 
ATOM 883  N NZ  . LYS A 1 132 ? 14.158  -12.241 -3.219 1.00 60.76 ? 134 LYS A NZ  1 
ATOM 884  N N   . ILE A 1 133 ? 10.225  -7.998  0.097  1.00 38.85 ? 135 ILE A N   1 
ATOM 885  C CA  . ILE A 1 133 ? 10.126  -6.940  1.096  1.00 34.25 ? 135 ILE A CA  1 
ATOM 886  C C   . ILE A 1 133 ? 10.755  -5.667  0.539  1.00 33.81 ? 135 ILE A C   1 
ATOM 887  O O   . ILE A 1 133 ? 11.729  -5.710  -0.221 1.00 28.93 ? 135 ILE A O   1 
ATOM 888  C CB  . ILE A 1 133 ? 10.776  -7.393  2.415  1.00 33.60 ? 135 ILE A CB  1 
ATOM 889  C CG1 . ILE A 1 133 ? 10.530  -6.379  3.530  1.00 32.03 ? 135 ILE A CG1 1 
ATOM 890  C CG2 . ILE A 1 133 ? 12.248  -7.711  2.233  1.00 31.91 ? 135 ILE A CG2 1 
ATOM 891  C CD1 . ILE A 1 133 ? 10.560  -6.996  4.926  1.00 30.88 ? 135 ILE A CD1 1 
ATOM 892  N N   . SER A 1 134 ? 10.157  -4.526  0.858  1.00 33.38 ? 136 SER A N   1 
ATOM 893  C CA  . SER A 1 134 ? 10.702  -3.279  0.355  1.00 29.78 ? 136 SER A CA  1 
ATOM 894  C C   . SER A 1 134 ? 11.815  -2.775  1.273  1.00 37.87 ? 136 SER A C   1 
ATOM 895  O O   . SER A 1 134 ? 12.031  -3.290  2.372  1.00 42.67 ? 136 SER A O   1 
ATOM 896  C CB  . SER A 1 134 ? 9.609   -2.235  0.251  1.00 32.49 ? 136 SER A CB  1 
ATOM 897  O OG  . SER A 1 134 ? 9.209   -1.855  1.549  1.00 37.76 ? 136 SER A OG  1 
ATOM 898  N N   . ARG A 1 135 ? 12.542  -1.754  0.809  1.00 41.82 ? 137 ARG A N   1 
ATOM 899  C CA  . ARG A 1 135 ? 13.510  -1.102  1.685  1.00 41.58 ? 137 ARG A CA  1 
ATOM 900  C C   . ARG A 1 135 ? 12.839  -0.641  2.971  1.00 44.99 ? 137 ARG A C   1 
ATOM 901  O O   . ARG A 1 135 ? 13.393  -0.802  4.064  1.00 45.99 ? 137 ARG A O   1 
ATOM 902  C CB  . ARG A 1 135 ? 14.157  0.082   0.974  1.00 46.97 ? 137 ARG A CB  1 
ATOM 903  C CG  . ARG A 1 135 ? 14.838  1.055   1.920  1.00 61.26 ? 137 ARG A CG  1 
ATOM 904  C CD  . ARG A 1 135 ? 15.446  2.250   1.175  1.00 75.14 ? 137 ARG A CD  1 
ATOM 905  N NE  . ARG A 1 135 ? 14.431  3.189   0.689  1.00 86.75 ? 137 ARG A NE  1 
ATOM 906  C CZ  . ARG A 1 135 ? 13.599  3.898   1.449  1.00 80.83 ? 137 ARG A CZ  1 
ATOM 907  N NH1 . ARG A 1 135 ? 13.672  3.878   2.771  1.00 73.64 ? 137 ARG A NH1 1 
ATOM 908  N NH2 . ARG A 1 135 ? 12.677  4.660   0.864  1.00 77.97 ? 137 ARG A NH2 1 
ATOM 909  N N   . ASP A 1 136 ? 11.624  -0.096  2.858  1.00 46.80 ? 138 ASP A N   1 
ATOM 910  C CA  . ASP A 1 136 ? 10.876  0.336   4.036  1.00 47.09 ? 138 ASP A CA  1 
ATOM 911  C C   . ASP A 1 136 ? 10.439  -0.850  4.883  1.00 46.47 ? 138 ASP A C   1 
ATOM 912  O O   . ASP A 1 136 ? 10.477  -0.781  6.116  1.00 51.74 ? 138 ASP A O   1 
ATOM 913  C CB  . ASP A 1 136 ? 9.675   1.167   3.602  1.00 51.25 ? 138 ASP A CB  1 
ATOM 914  C CG  . ASP A 1 136 ? 10.092  2.484   2.985  1.00 68.23 ? 138 ASP A CG  1 
ATOM 915  O OD1 . ASP A 1 136 ? 10.601  3.354   3.726  1.00 65.06 ? 138 ASP A OD1 1 
ATOM 916  O OD2 . ASP A 1 136 ? 9.970   2.622   1.746  1.00 77.41 ? 138 ASP A OD2 1 
ATOM 917  N N   . GLY A 1 137 ? 10.025  -1.948  4.244  1.00 47.45 ? 139 GLY A N   1 
ATOM 918  C CA  . GLY A 1 137 ? 9.741   -3.165  4.990  1.00 35.18 ? 139 GLY A CA  1 
ATOM 919  C C   . GLY A 1 137 ? 10.980  -3.762  5.630  1.00 31.58 ? 139 GLY A C   1 
ATOM 920  O O   . GLY A 1 137 ? 10.943  -4.205  6.779  1.00 30.74 ? 139 GLY A O   1 
ATOM 921  N N   . SER A 1 138 ? 12.091  -3.802  4.891  1.00 33.04 ? 140 SER A N   1 
ATOM 922  C CA  . SER A 1 138 ? 13.335  -4.271  5.484  1.00 31.78 ? 140 SER A CA  1 
ATOM 923  C C   . SER A 1 138 ? 13.818  -3.347  6.580  1.00 36.74 ? 140 SER A C   1 
ATOM 924  O O   . SER A 1 138 ? 14.559  -3.793  7.461  1.00 33.49 ? 140 SER A O   1 
ATOM 925  C CB  . SER A 1 138 ? 14.425  -4.417  4.430  1.00 35.16 ? 140 SER A CB  1 
ATOM 926  O OG  . SER A 1 138 ? 14.102  -5.435  3.505  1.00 47.37 ? 140 SER A OG  1 
ATOM 927  N N   . GLN A 1 139 ? 13.416  -2.073  6.546  1.00 36.27 ? 141 GLN A N   1 
ATOM 928  C CA  . GLN A 1 139 ? 13.788  -1.162  7.620  1.00 35.07 ? 141 GLN A CA  1 
ATOM 929  C C   . GLN A 1 139 ? 13.119  -1.564  8.928  1.00 32.05 ? 141 GLN A C   1 
ATOM 930  O O   . GLN A 1 139 ? 13.799  -1.779  9.940  1.00 32.33 ? 141 GLN A O   1 
ATOM 931  C CB  . GLN A 1 139 ? 13.433  0.277   7.246  1.00 39.68 ? 141 GLN A CB  1 
ATOM 932  C CG  . GLN A 1 139 ? 14.553  1.046   6.526  1.00 47.13 ? 141 GLN A CG  1 
ATOM 933  C CD  . GLN A 1 139 ? 14.138  2.465   6.101  1.00 57.49 ? 141 GLN A CD  1 
ATOM 934  O OE1 . GLN A 1 139 ? 14.767  3.076   5.231  1.00 62.92 ? 141 GLN A OE1 1 
ATOM 935  N NE2 . GLN A 1 139 ? 13.088  2.996   6.730  1.00 63.33 ? 141 GLN A NE2 1 
ATOM 936  N N   . VAL A 1 140 ? 11.786  -1.690  8.919  1.00 27.83 ? 142 VAL A N   1 
ATOM 937  C CA  . VAL A 1 140 ? 11.052  -2.023  10.138 1.00 26.50 ? 142 VAL A CA  1 
ATOM 938  C C   . VAL A 1 140 ? 11.485  -3.383  10.669 1.00 29.25 ? 142 VAL A C   1 
ATOM 939  O O   . VAL A 1 140 ? 11.739  -3.549  11.868 1.00 30.17 ? 142 VAL A O   1 
ATOM 940  C CB  . VAL A 1 140 ? 9.535   -1.982  9.888  1.00 27.17 ? 142 VAL A CB  1 
ATOM 941  C CG1 . VAL A 1 140 ? 8.796   -2.582  11.068 1.00 27.84 ? 142 VAL A CG1 1 
ATOM 942  C CG2 . VAL A 1 140 ? 9.069   -0.564  9.670  1.00 24.56 ? 142 VAL A CG2 1 
ATOM 943  N N   . LEU A 1 141 ? 11.574  -4.377  9.780  1.00 28.63 ? 143 LEU A N   1 
ATOM 944  C CA  . LEU A 1 141 ? 11.974  -5.724  10.180 1.00 26.08 ? 143 LEU A CA  1 
ATOM 945  C C   . LEU A 1 141 ? 13.269  -5.703  10.983 1.00 27.26 ? 143 LEU A C   1 
ATOM 946  O O   . LEU A 1 141 ? 13.421  -6.438  11.963 1.00 28.12 ? 143 LEU A O   1 
ATOM 947  C CB  . LEU A 1 141 ? 12.133  -6.599  8.937  1.00 22.29 ? 143 LEU A CB  1 
ATOM 948  C CG  . LEU A 1 141 ? 12.341  -8.076  9.213  1.00 20.50 ? 143 LEU A CG  1 
ATOM 949  C CD1 . LEU A 1 141 ? 11.478  -8.476  10.381 1.00 25.82 ? 143 LEU A CD1 1 
ATOM 950  C CD2 . LEU A 1 141 ? 12.009  -8.892  8.003  1.00 26.19 ? 143 LEU A CD2 1 
ATOM 951  N N   . GLU A 1 142 ? 14.207  -4.848  10.587 1.00 32.79 ? 144 GLU A N   1 
ATOM 952  C CA  . GLU A 1 142 ? 15.482  -4.737  11.283 1.00 34.40 ? 144 GLU A CA  1 
ATOM 953  C C   . GLU A 1 142 ? 15.332  -3.985  12.599 1.00 30.70 ? 144 GLU A C   1 
ATOM 954  O O   . GLU A 1 142 ? 15.937  -4.375  13.599 1.00 36.51 ? 144 GLU A O   1 
ATOM 955  C CB  . GLU A 1 142 ? 16.502  -4.059  10.366 1.00 39.57 ? 144 GLU A CB  1 
ATOM 956  C CG  . GLU A 1 142 ? 16.897  -4.949  9.191  1.00 52.42 ? 144 GLU A CG  1 
ATOM 957  C CD  . GLU A 1 142 ? 17.915  -4.316  8.233  1.00 79.57 ? 144 GLU A CD  1 
ATOM 958  O OE1 . GLU A 1 142 ? 17.715  -3.152  7.794  1.00 63.24 ? 144 GLU A OE1 1 
ATOM 959  O OE2 . GLU A 1 142 ? 18.911  -5.002  7.900  1.00 91.73 ? 144 GLU A OE2 1 
ATOM 960  N N   . ALA A 1 143 ? 14.529  -2.917  12.626 1.00 29.16 ? 145 ALA A N   1 
ATOM 961  C CA  . ALA A 1 143 ? 14.237  -2.239  13.888 1.00 26.34 ? 145 ALA A CA  1 
ATOM 962  C C   . ALA A 1 143 ? 13.629  -3.203  14.896 1.00 30.85 ? 145 ALA A C   1 
ATOM 963  O O   . ALA A 1 143 ? 14.000  -3.212  16.077 1.00 28.17 ? 145 ALA A O   1 
ATOM 964  C CB  . ALA A 1 143 ? 13.292  -1.066  13.646 1.00 24.42 ? 145 ALA A CB  1 
ATOM 965  N N   . LEU A 1 144 ? 12.686  -4.027  14.437 1.00 33.88 ? 146 LEU A N   1 
ATOM 966  C CA  . LEU A 1 144 ? 12.068  -5.030  15.294 1.00 30.85 ? 146 LEU A CA  1 
ATOM 967  C C   . LEU A 1 144 ? 13.087  -6.064  15.766 1.00 35.65 ? 146 LEU A C   1 
ATOM 968  O O   . LEU A 1 144 ? 13.158  -6.379  16.962 1.00 32.75 ? 146 LEU A O   1 
ATOM 969  C CB  . LEU A 1 144 ? 10.928  -5.695  14.533 1.00 23.09 ? 146 LEU A CB  1 
ATOM 970  C CG  . LEU A 1 144 ? 10.207  -6.845  15.212 1.00 24.82 ? 146 LEU A CG  1 
ATOM 971  C CD1 . LEU A 1 144 ? 9.411   -6.317  16.376 1.00 27.75 ? 146 LEU A CD1 1 
ATOM 972  C CD2 . LEU A 1 144 ? 9.283   -7.482  14.215 1.00 25.16 ? 146 LEU A CD2 1 
ATOM 973  N N   . LYS A 1 145 ? 13.899  -6.593  14.834 1.00 34.83 ? 147 LYS A N   1 
ATOM 974  C CA  . LYS A 1 145 ? 14.815  -7.687  15.149 1.00 34.61 ? 147 LYS A CA  1 
ATOM 975  C C   . LYS A 1 145 ? 15.801  -7.299  16.248 1.00 39.02 ? 147 LYS A C   1 
ATOM 976  O O   . LYS A 1 145 ? 16.186  -8.148  17.065 1.00 40.01 ? 147 LYS A O   1 
ATOM 977  C CB  . LYS A 1 145 ? 15.561  -8.118  13.881 1.00 32.35 ? 147 LYS A CB  1 
ATOM 978  C CG  . LYS A 1 145 ? 15.027  -9.414  13.228 1.00 39.32 ? 147 LYS A CG  1 
ATOM 979  C CD  . LYS A 1 145 ? 15.984  -10.037 12.156 1.00 47.36 ? 147 LYS A CD  1 
ATOM 980  C CE  . LYS A 1 145 ? 17.283  -10.740 12.649 1.00 47.72 ? 147 LYS A CE  1 
ATOM 981  N NZ  . LYS A 1 145 ? 17.140  -12.245 12.902 1.00 34.18 ? 147 LYS A NZ  1 
ATOM 982  N N   . GLY A 1 146 ? 16.199  -6.026  16.302 1.00 34.63 ? 148 GLY A N   1 
ATOM 983  C CA  . GLY A 1 146 ? 17.175  -5.510  17.242 1.00 35.35 ? 148 GLY A CA  1 
ATOM 984  C C   . GLY A 1 146 ? 16.624  -4.987  18.547 1.00 35.24 ? 148 GLY A C   1 
ATOM 985  O O   . GLY A 1 146 ? 17.385  -4.505  19.396 1.00 33.75 ? 148 GLY A O   1 
ATOM 986  N N   . LEU A 1 147 ? 15.309  -5.045  18.717 1.00 33.97 ? 149 LEU A N   1 
ATOM 987  C CA  . LEU A 1 147 ? 14.685  -4.808  20.004 1.00 32.43 ? 149 LEU A CA  1 
ATOM 988  C C   . LEU A 1 147 ? 15.019  -5.968  20.941 1.00 33.88 ? 149 LEU A C   1 
ATOM 989  O O   . LEU A 1 147 ? 15.412  -7.053  20.498 1.00 33.52 ? 149 LEU A O   1 
ATOM 990  C CB  . LEU A 1 147 ? 13.178  -4.683  19.804 1.00 32.04 ? 149 LEU A CB  1 
ATOM 991  C CG  . LEU A 1 147 ? 12.749  -3.389  19.125 1.00 29.75 ? 149 LEU A CG  1 
ATOM 992  C CD1 . LEU A 1 147 ? 11.239  -3.310  19.063 1.00 35.21 ? 149 LEU A CD1 1 
ATOM 993  C CD2 . LEU A 1 147 ? 13.311  -2.220  19.904 1.00 26.97 ? 149 LEU A CD2 1 
ATOM 994  N N   . ASP A 1 148 ? 14.863  -5.747  22.247 1.00 34.00 ? 150 ASP A N   1 
ATOM 995  C CA  . ASP A 1 148 ? 15.173  -6.851  23.147 1.00 34.77 ? 150 ASP A CA  1 
ATOM 996  C C   . ASP A 1 148 ? 14.022  -7.858  23.128 1.00 28.29 ? 150 ASP A C   1 
ATOM 997  O O   . ASP A 1 148 ? 12.916  -7.552  22.675 1.00 28.25 ? 150 ASP A O   1 
ATOM 998  C CB  . ASP A 1 148 ? 15.511  -6.337  24.564 1.00 34.32 ? 150 ASP A CB  1 
ATOM 999  C CG  . ASP A 1 148 ? 14.296  -5.905  25.376 1.00 31.83 ? 150 ASP A CG  1 
ATOM 1000 O OD1 . ASP A 1 148 ? 13.410  -6.731  25.687 1.00 37.65 ? 150 ASP A OD1 1 
ATOM 1001 O OD2 . ASP A 1 148 ? 14.232  -4.712  25.711 1.00 28.90 ? 150 ASP A OD2 1 
ATOM 1002 N N   . PHE A 1 149 ? 14.318  -9.087  23.574 1.00 23.67 ? 151 PHE A N   1 
ATOM 1003 C CA  . PHE A 1 149 ? 13.350  -10.175 23.467 1.00 22.98 ? 151 PHE A CA  1 
ATOM 1004 C C   . PHE A 1 149 ? 11.972  -9.742  23.925 1.00 25.41 ? 151 PHE A C   1 
ATOM 1005 O O   . PHE A 1 149 ? 10.979  -9.917  23.209 1.00 28.43 ? 151 PHE A O   1 
ATOM 1006 C CB  . PHE A 1 149 ? 13.799  -11.383 24.281 1.00 27.23 ? 151 PHE A CB  1 
ATOM 1007 C CG  . PHE A 1 149 ? 12.785  -12.511 24.306 1.00 27.06 ? 151 PHE A CG  1 
ATOM 1008 C CD1 . PHE A 1 149 ? 12.485  -13.229 23.161 1.00 26.79 ? 151 PHE A CD1 1 
ATOM 1009 C CD2 . PHE A 1 149 ? 12.101  -12.815 25.477 1.00 22.92 ? 151 PHE A CD2 1 
ATOM 1010 C CE1 . PHE A 1 149 ? 11.547  -14.248 23.199 1.00 30.23 ? 151 PHE A CE1 1 
ATOM 1011 C CE2 . PHE A 1 149 ? 11.172  -13.828 25.514 1.00 22.76 ? 151 PHE A CE2 1 
ATOM 1012 C CZ  . PHE A 1 149 ? 10.894  -14.547 24.379 1.00 25.69 ? 151 PHE A CZ  1 
ATOM 1013 N N   . CYS A 1 150 ? 11.893  -9.156  25.115 1.00 27.95 ? 152 CYS A N   1 
ATOM 1014 C CA  . CYS A 1 150 ? 10.586  -8.815  25.658 1.00 31.59 ? 152 CYS A CA  1 
ATOM 1015 C C   . CYS A 1 150 ? 9.901   -7.743  24.821 1.00 27.84 ? 152 CYS A C   1 
ATOM 1016 O O   . CYS A 1 150 ? 8.675   -7.780  24.656 1.00 29.07 ? 152 CYS A O   1 
ATOM 1017 C CB  . CYS A 1 150 ? 10.730  -8.399  27.123 1.00 34.47 ? 152 CYS A CB  1 
ATOM 1018 S SG  . CYS A 1 150 ? 11.222  -9.788  28.252 1.00 38.83 ? 152 CYS A SG  1 
ATOM 1019 N N   . GLN A 1 151 ? 10.680  -6.831  24.233 1.00 24.46 ? 153 GLN A N   1 
ATOM 1020 C CA  . GLN A 1 151 ? 10.114  -5.768  23.405 1.00 27.31 ? 153 GLN A CA  1 
ATOM 1021 C C   . GLN A 1 151 ? 9.516   -6.301  22.109 1.00 32.66 ? 153 GLN A C   1 
ATOM 1022 O O   . GLN A 1 151 ? 8.475   -5.807  21.651 1.00 31.17 ? 153 GLN A O   1 
ATOM 1023 C CB  . GLN A 1 151 ? 11.181  -4.733  23.092 1.00 28.34 ? 153 GLN A CB  1 
ATOM 1024 C CG  . GLN A 1 151 ? 11.553  -3.945  24.292 1.00 34.17 ? 153 GLN A CG  1 
ATOM 1025 C CD  . GLN A 1 151 ? 12.487  -2.822  23.978 1.00 32.29 ? 153 GLN A CD  1 
ATOM 1026 O OE1 . GLN A 1 151 ? 13.460  -2.998  23.242 1.00 30.91 ? 153 GLN A OE1 1 
ATOM 1027 N NE2 . GLN A 1 151 ? 12.183  -1.637  24.513 1.00 34.88 ? 153 GLN A NE2 1 
ATOM 1028 N N   . GLN A 1 152 ? 10.177  -7.280  21.481 1.00 32.10 ? 154 GLN A N   1 
ATOM 1029 C CA  . GLN A 1 152 ? 9.622   -7.884  20.274 1.00 29.65 ? 154 GLN A CA  1 
ATOM 1030 C C   . GLN A 1 152 ? 8.267   -8.518  20.568 1.00 30.29 ? 154 GLN A C   1 
ATOM 1031 O O   . GLN A 1 152 ? 7.306   -8.361  19.798 1.00 25.31 ? 154 GLN A O   1 
ATOM 1032 C CB  . GLN A 1 152 ? 10.608  -8.909  19.726 1.00 25.30 ? 154 GLN A CB  1 
ATOM 1033 C CG  . GLN A 1 152 ? 11.941  -8.294  19.359 1.00 28.96 ? 154 GLN A CG  1 
ATOM 1034 C CD  . GLN A 1 152 ? 12.947  -9.309  18.863 1.00 32.55 ? 154 GLN A CD  1 
ATOM 1035 O OE1 . GLN A 1 152 ? 12.584  -10.410 18.458 1.00 37.83 ? 154 GLN A OE1 1 
ATOM 1036 N NE2 . GLN A 1 152 ? 14.226  -8.954  18.922 1.00 32.73 ? 154 GLN A NE2 1 
ATOM 1037 N N   . ILE A 1 153 ? 8.165   -9.204  21.710 1.00 31.82 ? 155 ILE A N   1 
ATOM 1038 C CA  . ILE A 1 153 ? 6.906   -9.818  22.115 1.00 27.76 ? 155 ILE A CA  1 
ATOM 1039 C C   . ILE A 1 153 ? 5.820   -8.767  22.255 1.00 31.51 ? 155 ILE A C   1 
ATOM 1040 O O   . ILE A 1 153 ? 4.688   -8.958  21.794 1.00 33.34 ? 155 ILE A O   1 
ATOM 1041 C CB  . ILE A 1 153 ? 7.108   -10.617 23.411 1.00 23.72 ? 155 ILE A CB  1 
ATOM 1042 C CG1 . ILE A 1 153 ? 7.908   -11.870 23.090 1.00 30.01 ? 155 ILE A CG1 1 
ATOM 1043 C CG2 . ILE A 1 153 ? 5.798   -11.008 24.006 1.00 25.53 ? 155 ILE A CG2 1 
ATOM 1044 C CD1 . ILE A 1 153 ? 7.969   -12.819 24.211 1.00 38.83 ? 155 ILE A CD1 1 
ATOM 1045 N N   . THR A 1 154 ? 6.147   -7.629  22.875 1.00 34.88 ? 156 THR A N   1 
ATOM 1046 C CA  . THR A 1 154 ? 5.175   -6.545  22.980 1.00 31.72 ? 156 THR A CA  1 
ATOM 1047 C C   . THR A 1 154 ? 4.778   -6.032  21.603 1.00 29.21 ? 156 THR A C   1 
ATOM 1048 O O   . THR A 1 154 ? 3.585   -5.942  21.288 1.00 28.81 ? 156 THR A O   1 
ATOM 1049 C CB  . THR A 1 154 ? 5.723   -5.409  23.848 1.00 28.58 ? 156 THR A CB  1 
ATOM 1050 O OG1 . THR A 1 154 ? 5.984   -5.896  25.172 1.00 26.95 ? 156 THR A OG1 1 
ATOM 1051 C CG2 . THR A 1 154 ? 4.731   -4.276  23.920 1.00 24.55 ? 156 THR A CG2 1 
ATOM 1052 N N   . VAL A 1 155 ? 5.767   -5.705  20.762 1.00 27.34 ? 157 VAL A N   1 
ATOM 1053 C CA  . VAL A 1 155 ? 5.453   -5.185  19.436 1.00 25.88 ? 157 VAL A CA  1 
ATOM 1054 C C   . VAL A 1 155 ? 4.562   -6.169  18.696 1.00 29.20 ? 157 VAL A C   1 
ATOM 1055 O O   . VAL A 1 155 ? 3.535   -5.792  18.120 1.00 31.62 ? 157 VAL A O   1 
ATOM 1056 C CB  . VAL A 1 155 ? 6.735   -4.894  18.638 1.00 23.45 ? 157 VAL A CB  1 
ATOM 1057 C CG1 . VAL A 1 155 ? 6.375   -4.479  17.252 1.00 21.70 ? 157 VAL A CG1 1 
ATOM 1058 C CG2 . VAL A 1 155 ? 7.549   -3.826  19.288 1.00 30.23 ? 157 VAL A CG2 1 
ATOM 1059 N N   . LEU A 1 156 ? 4.926   -7.455  18.728 1.00 27.85 ? 158 LEU A N   1 
ATOM 1060 C CA  . LEU A 1 156 ? 4.145   -8.445  17.996 1.00 25.27 ? 158 LEU A CA  1 
ATOM 1061 C C   . LEU A 1 156 ? 2.775   -8.667  18.625 1.00 28.53 ? 158 LEU A C   1 
ATOM 1062 O O   . LEU A 1 156 ? 1.816   -8.984  17.914 1.00 29.63 ? 158 LEU A O   1 
ATOM 1063 C CB  . LEU A 1 156 ? 4.888   -9.773  17.914 1.00 21.22 ? 158 LEU A CB  1 
ATOM 1064 C CG  . LEU A 1 156 ? 6.197   -9.862  17.152 1.00 24.01 ? 158 LEU A CG  1 
ATOM 1065 C CD1 . LEU A 1 156 ? 6.723   -11.302 17.200 1.00 23.99 ? 158 LEU A CD1 1 
ATOM 1066 C CD2 . LEU A 1 156 ? 6.026   -9.365  15.725 1.00 21.76 ? 158 LEU A CD2 1 
ATOM 1067 N N   . ARG A 1 157 ? 2.659   -8.554  19.946 1.00 27.06 ? 159 ARG A N   1 
ATOM 1068 C CA  . ARG A 1 157 ? 1.347   -8.738  20.542 1.00 25.93 ? 159 ARG A CA  1 
ATOM 1069 C C   . ARG A 1 157 ? 0.431   -7.595  20.128 1.00 30.00 ? 159 ARG A C   1 
ATOM 1070 O O   . ARG A 1 157 ? -0.706  -7.816  19.695 1.00 29.87 ? 159 ARG A O   1 
ATOM 1071 C CB  . ARG A 1 157 ? 1.463   -8.832  22.062 1.00 28.16 ? 159 ARG A CB  1 
ATOM 1072 C CG  . ARG A 1 157 ? 0.121   -8.931  22.782 1.00 35.68 ? 159 ARG A CG  1 
ATOM 1073 C CD  . ARG A 1 157 ? 0.267   -9.330  24.270 1.00 39.66 ? 159 ARG A CD  1 
ATOM 1074 N NE  . ARG A 1 157 ? 1.409   -8.685  24.912 1.00 39.95 ? 159 ARG A NE  1 
ATOM 1075 C CZ  . ARG A 1 157 ? 1.456   -7.403  25.265 1.00 38.00 ? 159 ARG A CZ  1 
ATOM 1076 N NH1 . ARG A 1 157 ? 0.415   -6.598  25.100 1.00 34.45 ? 159 ARG A NH1 1 
ATOM 1077 N NH2 . ARG A 1 157 ? 2.579   -6.912  25.793 1.00 40.23 ? 159 ARG A NH2 1 
ATOM 1078 N N   . LYS A 1 158 ? 0.938   -6.366  20.185 1.00 34.28 ? 160 LYS A N   1 
ATOM 1079 C CA  . LYS A 1 158 ? 0.079   -5.223  19.925 1.00 28.75 ? 160 LYS A CA  1 
ATOM 1080 C C   . LYS A 1 158 ? -0.296  -5.134  18.453 1.00 30.97 ? 160 LYS A C   1 
ATOM 1081 O O   . LYS A 1 158 ? -1.473  -4.955  18.132 1.00 38.58 ? 160 LYS A O   1 
ATOM 1082 C CB  . LYS A 1 158 ? 0.740   -3.935  20.403 1.00 26.68 ? 160 LYS A CB  1 
ATOM 1083 C CG  . LYS A 1 158 ? 0.192   -2.708  19.678 1.00 48.08 ? 160 LYS A CG  1 
ATOM 1084 C CD  . LYS A 1 158 ? -1.284  -2.307  20.057 1.00 54.15 ? 160 LYS A CD  1 
ATOM 1085 C CE  . LYS A 1 158 ? -1.482  -0.758  20.065 1.00 47.27 ? 160 LYS A CE  1 
ATOM 1086 N NZ  . LYS A 1 158 ? -2.828  -0.292  19.616 1.00 42.59 ? 160 LYS A NZ  1 
ATOM 1087 N N   . VAL A 1 159 ? 0.674   -5.277  17.537 1.00 32.63 ? 161 VAL A N   1 
ATOM 1088 C CA  . VAL A 1 159 ? 0.354   -5.092  16.115 1.00 33.61 ? 161 VAL A CA  1 
ATOM 1089 C C   . VAL A 1 159 ? -0.653  -6.133  15.630 1.00 33.25 ? 161 VAL A C   1 
ATOM 1090 O O   . VAL A 1 159 ? -1.453  -5.846  14.735 1.00 39.53 ? 161 VAL A O   1 
ATOM 1091 C CB  . VAL A 1 159 ? 1.608   -5.110  15.210 1.00 24.70 ? 161 VAL A CB  1 
ATOM 1092 C CG1 . VAL A 1 159 ? 2.624   -4.068  15.644 1.00 25.04 ? 161 VAL A CG1 1 
ATOM 1093 C CG2 . VAL A 1 159 ? 2.198   -6.492  15.112 1.00 24.46 ? 161 VAL A CG2 1 
ATOM 1094 N N   . VAL A 1 160 ? -0.639  -7.348  16.190 1.00 33.98 ? 162 VAL A N   1 
ATOM 1095 C CA  . VAL A 1 160 ? -1.576  -8.376  15.736 1.00 32.94 ? 162 VAL A CA  1 
ATOM 1096 C C   . VAL A 1 160 ? -2.879  -8.338  16.513 1.00 33.08 ? 162 VAL A C   1 
ATOM 1097 O O   . VAL A 1 160 ? -3.859  -8.971  16.087 1.00 34.30 ? 162 VAL A O   1 
ATOM 1098 C CB  . VAL A 1 160 ? -1.019  -9.813  15.820 1.00 29.59 ? 162 VAL A CB  1 
ATOM 1099 C CG1 . VAL A 1 160 ? 0.338   -9.933  15.115 1.00 27.00 ? 162 VAL A CG1 1 
ATOM 1100 C CG2 . VAL A 1 160 ? -0.958  -10.295 17.255 1.00 24.60 ? 162 VAL A CG2 1 
ATOM 1101 N N   . ALA A 1 161 ? -2.924  -7.625  17.638 1.00 30.95 ? 163 ALA A N   1 
ATOM 1102 C CA  . ALA A 1 161 ? -4.174  -7.529  18.375 1.00 30.96 ? 163 ALA A CA  1 
ATOM 1103 C C   . ALA A 1 161 ? -5.136  -6.519  17.762 1.00 36.69 ? 163 ALA A C   1 
ATOM 1104 O O   . ALA A 1 161 ? -6.344  -6.641  17.981 1.00 42.02 ? 163 ALA A O   1 
ATOM 1105 C CB  . ALA A 1 161 ? -3.908  -7.180  19.832 1.00 24.77 ? 163 ALA A CB  1 
ATOM 1106 N N   . ASP A 1 162 ? -4.645  -5.538  16.997 1.00 35.06 ? 164 ASP A N   1 
ATOM 1107 C CA  . ASP A 1 162 ? -5.519  -4.619  16.274 1.00 37.47 ? 164 ASP A CA  1 
ATOM 1108 C C   . ASP A 1 162 ? -5.910  -5.150  14.906 1.00 40.90 ? 164 ASP A C   1 
ATOM 1109 O O   . ASP A 1 162 ? -6.447  -4.389  14.098 1.00 38.42 ? 164 ASP A O   1 
ATOM 1110 C CB  . ASP A 1 162 ? -4.872  -3.238  16.077 1.00 36.67 ? 164 ASP A CB  1 
ATOM 1111 C CG  . ASP A 1 162 ? -4.575  -2.533  17.383 1.00 57.11 ? 164 ASP A CG  1 
ATOM 1112 O OD1 . ASP A 1 162 ? -5.532  -2.111  18.064 1.00 71.02 ? 164 ASP A OD1 1 
ATOM 1113 O OD2 . ASP A 1 162 ? -3.384  -2.328  17.698 1.00 59.11 ? 164 ASP A OD2 1 
ATOM 1114 N N   . MET A 1 163 ? -5.633  -6.418  14.616 1.00 38.68 ? 165 MET A N   1 
ATOM 1115 C CA  . MET A 1 163 ? -5.908  -6.976  13.301 1.00 33.45 ? 165 MET A CA  1 
ATOM 1116 C C   . MET A 1 163 ? -7.307  -7.595  13.258 1.00 35.17 ? 165 MET A C   1 
ATOM 1117 O O   . MET A 1 163 ? -7.851  -8.042  14.273 1.00 33.45 ? 165 MET A O   1 
ATOM 1118 C CB  . MET A 1 163 ? -4.839  -8.007  12.941 1.00 29.11 ? 165 MET A CB  1 
ATOM 1119 C CG  . MET A 1 163 ? -3.618  -7.379  12.311 1.00 28.35 ? 165 MET A CG  1 
ATOM 1120 S SD  . MET A 1 163 ? -2.317  -8.500  11.747 1.00 34.90 ? 165 MET A SD  1 
ATOM 1121 C CE  . MET A 1 163 ? -1.372  -7.340  10.753 1.00 36.13 ? 165 MET A CE  1 
ATOM 1122 N N   . GLY A 1 164 ? -7.901  -7.601  12.069 1.00 31.19 ? 166 GLY A N   1 
ATOM 1123 C CA  . GLY A 1 164 ? -9.273  -8.058  11.979 1.00 29.28 ? 166 GLY A CA  1 
ATOM 1124 C C   . GLY A 1 164 ? -10.228 -7.031  12.556 1.00 28.27 ? 166 GLY A C   1 
ATOM 1125 O O   . GLY A 1 164 ? -10.034 -5.820  12.428 1.00 27.03 ? 166 GLY A O   1 
ATOM 1126 N N   . VAL A 1 165 ? -11.277 -7.523  13.203 1.00 27.34 ? 167 VAL A N   1 
ATOM 1127 C CA  . VAL A 1 165 ? -12.382 -6.707  13.697 1.00 25.48 ? 167 VAL A CA  1 
ATOM 1128 C C   . VAL A 1 165 ? -12.951 -7.399  14.930 1.00 31.92 ? 167 VAL A C   1 
ATOM 1129 O O   . VAL A 1 165 ? -13.171 -8.614  14.914 1.00 34.44 ? 167 VAL A O   1 
ATOM 1130 C CB  . VAL A 1 165 ? -13.480 -6.547  12.624 1.00 23.04 ? 167 VAL A CB  1 
ATOM 1131 C CG1 . VAL A 1 165 ? -14.753 -5.998  13.235 1.00 26.05 ? 167 VAL A CG1 1 
ATOM 1132 C CG2 . VAL A 1 165 ? -13.012 -5.694  11.460 1.00 22.48 ? 167 VAL A CG2 1 
ATOM 1133 N N   . ASP A 1 166 ? -13.224 -6.649  16.000 1.00 34.14 ? 168 ASP A N   1 
ATOM 1134 C CA  . ASP A 1 166 ? -13.876 -7.244  17.201 1.00 33.20 ? 168 ASP A CA  1 
ATOM 1135 C C   . ASP A 1 166 ? -15.381 -7.035  17.119 1.00 35.08 ? 168 ASP A C   1 
ATOM 1136 O O   . ASP A 1 166 ? -15.836 -5.924  17.419 1.00 39.38 ? 168 ASP A O   1 
ATOM 1137 C CB  . ASP A 1 166 ? -13.403 -6.642  18.522 1.00 35.85 ? 168 ASP A CB  1 
ATOM 1138 C CG  . ASP A 1 166 ? -13.877 -7.399  19.749 1.00 40.85 ? 168 ASP A CG  1 
ATOM 1139 O OD1 . ASP A 1 166 ? -14.729 -8.288  19.599 1.00 42.54 ? 168 ASP A OD1 1 
ATOM 1140 O OD2 . ASP A 1 166 ? -13.388 -7.089  20.846 1.00 47.78 ? 168 ASP A OD2 1 
ATOM 1141 N N   . PRO A 1 167 ? -16.194 -8.045  16.719 1.00 34.99 ? 169 PRO A N   1 
ATOM 1142 C CA  . PRO A 1 167 ? -17.649 -7.892  16.711 1.00 33.27 ? 169 PRO A CA  1 
ATOM 1143 C C   . PRO A 1 167 ? -18.123 -7.497  18.115 1.00 34.83 ? 169 PRO A C   1 
ATOM 1144 O O   . PRO A 1 167 ? -18.957 -6.619  18.221 1.00 40.10 ? 169 PRO A O   1 
ATOM 1145 C CB  . PRO A 1 167 ? -18.189 -9.278  16.329 1.00 29.86 ? 169 PRO A CB  1 
ATOM 1146 C CG  . PRO A 1 167 ? -17.031 -10.219 16.571 1.00 38.77 ? 169 PRO A CG  1 
ATOM 1147 C CD  . PRO A 1 167 ? -15.800 -9.391  16.275 1.00 34.11 ? 169 PRO A CD  1 
ATOM 1148 N N   . LEU A 1 168 ? -17.576 -8.146  19.147 1.00 34.19 ? 170 LEU A N   1 
ATOM 1149 C CA  . LEU A 1 168 ? -17.941 -7.797  20.539 1.00 34.77 ? 170 LEU A CA  1 
ATOM 1150 C C   . LEU A 1 168 ? -17.709 -6.299  20.755 1.00 40.92 ? 170 LEU A C   1 
ATOM 1151 O O   . LEU A 1 168 ? -18.596 -5.642  21.332 1.00 46.61 ? 170 LEU A O   1 
ATOM 1152 C CB  . LEU A 1 168 ? -17.130 -8.620  21.544 1.00 30.00 ? 170 LEU A CB  1 
ATOM 1153 C CG  . LEU A 1 168 ? -17.398 -10.127 21.557 1.00 30.00 ? 170 LEU A CG  1 
ATOM 1154 C CD1 . LEU A 1 168 ? -16.427 -10.836 22.489 1.00 30.00 ? 170 LEU A CD1 1 
ATOM 1155 C CD2 . LEU A 1 168 ? -18.837 -10.415 21.956 1.00 30.00 ? 170 LEU A CD2 1 
ATOM 1156 N N   . ALA A 1 169 ? -16.564 -5.785  20.297 1.00 48.06 ? 171 ALA A N   1 
ATOM 1157 C CA  . ALA A 1 169 ? -16.265 -4.339  20.430 1.00 57.28 ? 171 ALA A CA  1 
ATOM 1158 C C   . ALA A 1 169 ? -16.721 -3.602  19.166 1.00 54.69 ? 171 ALA A C   1 
ATOM 1159 O O   . ALA A 1 169 ? -17.746 -4.026  18.597 1.00 57.87 ? 171 ALA A O   1 
ATOM 1160 C CB  . ALA A 1 169 ? -14.793 -4.137  20.687 1.00 58.52 ? 171 ALA A CB  1 
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