data_9H1K
# 
_entry.id   9H1K 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.404 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9H1K         pdb_00009h1k 10.2210/pdb9h1k/pdb 
WWPDB D_1292142244 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-04-23 ? 
2 'Structure model' 1 1 2025-06-18 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  2 'Structure model' '_citation.country'                 
2  2 'Structure model' '_citation.journal_abbrev'          
3  2 'Structure model' '_citation.journal_id_ASTM'         
4  2 'Structure model' '_citation.journal_id_CSD'          
5  2 'Structure model' '_citation.journal_id_ISSN'         
6  2 'Structure model' '_citation.journal_volume'          
7  2 'Structure model' '_citation.pdbx_database_id_DOI'    
8  2 'Structure model' '_citation.pdbx_database_id_PubMed' 
9  2 'Structure model' '_citation.title'                   
10 2 'Structure model' '_citation.year'                    
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9H1K 
_pdbx_database_status.recvd_initial_deposition_date   2024-10-09 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_database_related.content_type 
_pdbx_database_related.db_id 
_pdbx_database_related.db_name 
_pdbx_database_related.details 
unspecified 9MUK PDB . 
unspecified 9MUJ PDB . 
# 
loop_
_pdbx_contact_author.id 
_pdbx_contact_author.email 
_pdbx_contact_author.name_first 
_pdbx_contact_author.name_last 
_pdbx_contact_author.name_mi 
_pdbx_contact_author.role 
_pdbx_contact_author.identifier_ORCID 
2 labar.geoffray@gmail.com Geoffray Labar   ? 'principal investigator/group leader' 0000-0002-9164-2062 
3 yousra.tanouti@ulb.be    Yousra   Tanouti ? 'principal investigator/group leader' 0009-0004-1827-578X 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Tanouti, Y.'   1 0009-0004-1827-578X 
'Roovers, M.'   2 ?                   
'Droogmans, L.' 3 ?                   
'Van Elder, D.' 4 ?                   
'Kruys, V.'     5 ?                   
'Labar, G.'     6 0000-0002-9164-2062 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Nucleic Acids Res.' 
_citation.journal_id_ASTM           NARHAD 
_citation.journal_id_CSD            0389 
_citation.journal_id_ISSN           1362-4962 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            53 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
;Structural insight into the novel Thermus thermophilus SPOUT methyltransferase RlmR catalysing Um2552 formation in the 23S rRNA A-loop: a case of convergent evolution.
;
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1093/nar/gkaf432 
_citation.pdbx_database_id_PubMed   40444636 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Tanouti, Y.'   1  0009-0004-1827-578X 
primary 'Roovers, M.'   2  ?                   
primary 'Wolff, P.'     3  ?                   
primary 'Lechner, A.'   4  ?                   
primary 'Van Elder, D.' 5  ?                   
primary 'Feller, A.'    6  ?                   
primary 'Soin, R.'      7  ?                   
primary 'Gueydan, C.'   8  ?                   
primary 'Kruys, V.'     9  ?                   
primary 'Droogmans, L.' 10 ?                   
primary 'Labar, G.'     11 ?                   
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man '23S rRNA methyltransferase' 30239.713 2   2.1.1.- ? ? ? 
2 polymer     man 'RNA (59-MER)'               19077.344 1   ?       ? ? ? 
3 non-polymer syn S-ADENOSYL-L-HOMOCYSTEINE    384.411   2   ?       ? ? ? 
4 water       nat water                        18.015    483 ?       ? ? ? 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)'   no no 
;MGSSHHHHHHSSGLVPRGSHMRIESPQNPRVKALAALKERKERERTGRFLVEGRREVERALEAGLSLETLLLGPKARPED
RALAGGAEVLELSERALARVSARENPAQVLGVFRLPRRSLAGVTLGAAPLVLVLLGLEKPGNLGAILRAADGAGADLVLV
AEGVDLFSPQVIRNSTGAVFALPVYPVAEEEAARFLEEQNLPLVAATPEGERLYWEGDYRGGVAFLLGAEDKGLPEAWKR
RAQVRVRIPMRGRADSLNVAVTAALLLYEALRQRSGGAPL
;
;MGSSHHHHHHSSGLVPRGSHMRIESPQNPRVKALAALKERKERERTGRFLVEGRREVERALEAGLSLETLLLGPKARPED
RALAGGAEVLELSERALARVSARENPAQVLGVFRLPRRSLAGVTLGAAPLVLVLLGLEKPGNLGAILRAADGAGADLVLV
AEGVDLFSPQVIRNSTGAVFALPVYPVAEEEAARFLEEQNLPLVAATPEGERLYWEGDYRGGVAFLLGAEDKGLPEAWKR
RAQVRVRIPMRGRADSLNVAVTAALLLYEALRQRSGGAPL
;
A,B ? 
2 polyribonucleotide no no GUCGCAUCCUGGGGCUGAAGAAGGUCCCAAGGGUUGGGCUGUUCGCCCAUUAAAGCGGC 
GUCGCAUCCUGGGGCUGAAGAAGGUCCCAAGGGUUGGGCUGUUCGCCCAUUAAAGCGGC C   ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
3 S-ADENOSYL-L-HOMOCYSTEINE SAH 
4 water                     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   GLY n 
1 3   SER n 
1 4   SER n 
1 5   HIS n 
1 6   HIS n 
1 7   HIS n 
1 8   HIS n 
1 9   HIS n 
1 10  HIS n 
1 11  SER n 
1 12  SER n 
1 13  GLY n 
1 14  LEU n 
1 15  VAL n 
1 16  PRO n 
1 17  ARG n 
1 18  GLY n 
1 19  SER n 
1 20  HIS n 
1 21  MET n 
1 22  ARG n 
1 23  ILE n 
1 24  GLU n 
1 25  SER n 
1 26  PRO n 
1 27  GLN n 
1 28  ASN n 
1 29  PRO n 
1 30  ARG n 
1 31  VAL n 
1 32  LYS n 
1 33  ALA n 
1 34  LEU n 
1 35  ALA n 
1 36  ALA n 
1 37  LEU n 
1 38  LYS n 
1 39  GLU n 
1 40  ARG n 
1 41  LYS n 
1 42  GLU n 
1 43  ARG n 
1 44  GLU n 
1 45  ARG n 
1 46  THR n 
1 47  GLY n 
1 48  ARG n 
1 49  PHE n 
1 50  LEU n 
1 51  VAL n 
1 52  GLU n 
1 53  GLY n 
1 54  ARG n 
1 55  ARG n 
1 56  GLU n 
1 57  VAL n 
1 58  GLU n 
1 59  ARG n 
1 60  ALA n 
1 61  LEU n 
1 62  GLU n 
1 63  ALA n 
1 64  GLY n 
1 65  LEU n 
1 66  SER n 
1 67  LEU n 
1 68  GLU n 
1 69  THR n 
1 70  LEU n 
1 71  LEU n 
1 72  LEU n 
1 73  GLY n 
1 74  PRO n 
1 75  LYS n 
1 76  ALA n 
1 77  ARG n 
1 78  PRO n 
1 79  GLU n 
1 80  ASP n 
1 81  ARG n 
1 82  ALA n 
1 83  LEU n 
1 84  ALA n 
1 85  GLY n 
1 86  GLY n 
1 87  ALA n 
1 88  GLU n 
1 89  VAL n 
1 90  LEU n 
1 91  GLU n 
1 92  LEU n 
1 93  SER n 
1 94  GLU n 
1 95  ARG n 
1 96  ALA n 
1 97  LEU n 
1 98  ALA n 
1 99  ARG n 
1 100 VAL n 
1 101 SER n 
1 102 ALA n 
1 103 ARG n 
1 104 GLU n 
1 105 ASN n 
1 106 PRO n 
1 107 ALA n 
1 108 GLN n 
1 109 VAL n 
1 110 LEU n 
1 111 GLY n 
1 112 VAL n 
1 113 PHE n 
1 114 ARG n 
1 115 LEU n 
1 116 PRO n 
1 117 ARG n 
1 118 ARG n 
1 119 SER n 
1 120 LEU n 
1 121 ALA n 
1 122 GLY n 
1 123 VAL n 
1 124 THR n 
1 125 LEU n 
1 126 GLY n 
1 127 ALA n 
1 128 ALA n 
1 129 PRO n 
1 130 LEU n 
1 131 VAL n 
1 132 LEU n 
1 133 VAL n 
1 134 LEU n 
1 135 LEU n 
1 136 GLY n 
1 137 LEU n 
1 138 GLU n 
1 139 LYS n 
1 140 PRO n 
1 141 GLY n 
1 142 ASN n 
1 143 LEU n 
1 144 GLY n 
1 145 ALA n 
1 146 ILE n 
1 147 LEU n 
1 148 ARG n 
1 149 ALA n 
1 150 ALA n 
1 151 ASP n 
1 152 GLY n 
1 153 ALA n 
1 154 GLY n 
1 155 ALA n 
1 156 ASP n 
1 157 LEU n 
1 158 VAL n 
1 159 LEU n 
1 160 VAL n 
1 161 ALA n 
1 162 GLU n 
1 163 GLY n 
1 164 VAL n 
1 165 ASP n 
1 166 LEU n 
1 167 PHE n 
1 168 SER n 
1 169 PRO n 
1 170 GLN n 
1 171 VAL n 
1 172 ILE n 
1 173 ARG n 
1 174 ASN n 
1 175 SER n 
1 176 THR n 
1 177 GLY n 
1 178 ALA n 
1 179 VAL n 
1 180 PHE n 
1 181 ALA n 
1 182 LEU n 
1 183 PRO n 
1 184 VAL n 
1 185 TYR n 
1 186 PRO n 
1 187 VAL n 
1 188 ALA n 
1 189 GLU n 
1 190 GLU n 
1 191 GLU n 
1 192 ALA n 
1 193 ALA n 
1 194 ARG n 
1 195 PHE n 
1 196 LEU n 
1 197 GLU n 
1 198 GLU n 
1 199 GLN n 
1 200 ASN n 
1 201 LEU n 
1 202 PRO n 
1 203 LEU n 
1 204 VAL n 
1 205 ALA n 
1 206 ALA n 
1 207 THR n 
1 208 PRO n 
1 209 GLU n 
1 210 GLY n 
1 211 GLU n 
1 212 ARG n 
1 213 LEU n 
1 214 TYR n 
1 215 TRP n 
1 216 GLU n 
1 217 GLY n 
1 218 ASP n 
1 219 TYR n 
1 220 ARG n 
1 221 GLY n 
1 222 GLY n 
1 223 VAL n 
1 224 ALA n 
1 225 PHE n 
1 226 LEU n 
1 227 LEU n 
1 228 GLY n 
1 229 ALA n 
1 230 GLU n 
1 231 ASP n 
1 232 LYS n 
1 233 GLY n 
1 234 LEU n 
1 235 PRO n 
1 236 GLU n 
1 237 ALA n 
1 238 TRP n 
1 239 LYS n 
1 240 ARG n 
1 241 ARG n 
1 242 ALA n 
1 243 GLN n 
1 244 VAL n 
1 245 ARG n 
1 246 VAL n 
1 247 ARG n 
1 248 ILE n 
1 249 PRO n 
1 250 MET n 
1 251 ARG n 
1 252 GLY n 
1 253 ARG n 
1 254 ALA n 
1 255 ASP n 
1 256 SER n 
1 257 LEU n 
1 258 ASN n 
1 259 VAL n 
1 260 ALA n 
1 261 VAL n 
1 262 THR n 
1 263 ALA n 
1 264 ALA n 
1 265 LEU n 
1 266 LEU n 
1 267 LEU n 
1 268 TYR n 
1 269 GLU n 
1 270 ALA n 
1 271 LEU n 
1 272 ARG n 
1 273 GLN n 
1 274 ARG n 
1 275 SER n 
1 276 GLY n 
1 277 GLY n 
1 278 ALA n 
1 279 PRO n 
1 280 LEU n 
2 1   G   n 
2 2   U   n 
2 3   C   n 
2 4   G   n 
2 5   C   n 
2 6   A   n 
2 7   U   n 
2 8   C   n 
2 9   C   n 
2 10  U   n 
2 11  G   n 
2 12  G   n 
2 13  G   n 
2 14  G   n 
2 15  C   n 
2 16  U   n 
2 17  G   n 
2 18  A   n 
2 19  A   n 
2 20  G   n 
2 21  A   n 
2 22  A   n 
2 23  G   n 
2 24  G   n 
2 25  U   n 
2 26  C   n 
2 27  C   n 
2 28  C   n 
2 29  A   n 
2 30  A   n 
2 31  G   n 
2 32  G   n 
2 33  G   n 
2 34  U   n 
2 35  U   n 
2 36  G   n 
2 37  G   n 
2 38  G   n 
2 39  C   n 
2 40  U   n 
2 41  G   n 
2 42  U   n 
2 43  U   n 
2 44  C   n 
2 45  G   n 
2 46  C   n 
2 47  C   n 
2 48  C   n 
2 49  A   n 
2 50  U   n 
2 51  U   n 
2 52  A   n 
2 53  A   n 
2 54  A   n 
2 55  G   n 
2 56  C   n 
2 57  G   n 
2 58  G   n 
2 59  C   n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 280 ? ? TT_C1712 ? ? ? ? ? ? 'Thermus thermophilus HB27' 262724 ? ? ? ? ? ? ? ? 
'Escherichia coli BL21(DE3)' 469008 ? ? ? ? ? ? ? Rosetta ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 59  ? ? ?        ? ? ? ? ? ? 'Thermus thermophilus HB27' 262724 ? ? ? ? ? ? ? ? 
'synthetic construct'        32630  ? ? ? ? ? ? ? ?       ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A   'RNA linking'       y "ADENOSINE-5'-MONOPHOSPHATE" ? 'C10 H14 N5 O7 P' 347.221 
ALA 'L-peptide linking' y ALANINE                      ? 'C3 H7 N O2'      89.093  
ARG 'L-peptide linking' y ARGININE                     ? 'C6 H15 N4 O2 1'  175.209 
ASN 'L-peptide linking' y ASPARAGINE                   ? 'C4 H8 N2 O3'     132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'              ? 'C4 H7 N O4'      133.103 
C   'RNA linking'       y "CYTIDINE-5'-MONOPHOSPHATE"  ? 'C9 H14 N3 O8 P'  323.197 
G   'RNA linking'       y "GUANOSINE-5'-MONOPHOSPHATE" ? 'C10 H14 N5 O8 P' 363.221 
GLN 'L-peptide linking' y GLUTAMINE                    ? 'C5 H10 N2 O3'    146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'              ? 'C5 H9 N O4'      147.129 
GLY 'peptide linking'   y GLYCINE                      ? 'C2 H5 N O2'      75.067  
HIS 'L-peptide linking' y HISTIDINE                    ? 'C6 H10 N3 O2 1'  156.162 
HOH non-polymer         . WATER                        ? 'H2 O'            18.015  
ILE 'L-peptide linking' y ISOLEUCINE                   ? 'C6 H13 N O2'     131.173 
LEU 'L-peptide linking' y LEUCINE                      ? 'C6 H13 N O2'     131.173 
LYS 'L-peptide linking' y LYSINE                       ? 'C6 H15 N2 O2 1'  147.195 
MET 'L-peptide linking' y METHIONINE                   ? 'C5 H11 N O2 S'   149.211 
PHE 'L-peptide linking' y PHENYLALANINE                ? 'C9 H11 N O2'     165.189 
PRO 'L-peptide linking' y PROLINE                      ? 'C5 H9 N O2'      115.130 
SAH non-polymer         . S-ADENOSYL-L-HOMOCYSTEINE    ? 'C14 H20 N6 O5 S' 384.411 
SER 'L-peptide linking' y SERINE                       ? 'C3 H7 N O3'      105.093 
THR 'L-peptide linking' y THREONINE                    ? 'C4 H9 N O3'      119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                   ? 'C11 H12 N2 O2'   204.225 
TYR 'L-peptide linking' y TYROSINE                     ? 'C9 H11 N O3'     181.189 
U   'RNA linking'       y "URIDINE-5'-MONOPHOSPHATE"   ? 'C9 H13 N2 O9 P'  324.181 
VAL 'L-peptide linking' y VALINE                       ? 'C5 H11 N O2'     117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   -19  ?    ?   ?   A . n 
A 1 2   GLY 2   -18  ?    ?   ?   A . n 
A 1 3   SER 3   -17  ?    ?   ?   A . n 
A 1 4   SER 4   -16  ?    ?   ?   A . n 
A 1 5   HIS 5   -15  ?    ?   ?   A . n 
A 1 6   HIS 6   -14  ?    ?   ?   A . n 
A 1 7   HIS 7   -13  ?    ?   ?   A . n 
A 1 8   HIS 8   -12  ?    ?   ?   A . n 
A 1 9   HIS 9   -11  ?    ?   ?   A . n 
A 1 10  HIS 10  -10  ?    ?   ?   A . n 
A 1 11  SER 11  -9   ?    ?   ?   A . n 
A 1 12  SER 12  -8   ?    ?   ?   A . n 
A 1 13  GLY 13  -7   ?    ?   ?   A . n 
A 1 14  LEU 14  -6   ?    ?   ?   A . n 
A 1 15  VAL 15  -5   ?    ?   ?   A . n 
A 1 16  PRO 16  -4   ?    ?   ?   A . n 
A 1 17  ARG 17  -3   ?    ?   ?   A . n 
A 1 18  GLY 18  -2   ?    ?   ?   A . n 
A 1 19  SER 19  -1   ?    ?   ?   A . n 
A 1 20  HIS 20  0    0    HIS HIS A . n 
A 1 21  MET 21  1    1    MET MET A . n 
A 1 22  ARG 22  2    2    ARG ARG A . n 
A 1 23  ILE 23  3    3    ILE ILE A . n 
A 1 24  GLU 24  4    4    GLU GLU A . n 
A 1 25  SER 25  5    5    SER SER A . n 
A 1 26  PRO 26  6    6    PRO PRO A . n 
A 1 27  GLN 27  7    7    GLN GLN A . n 
A 1 28  ASN 28  8    8    ASN ASN A . n 
A 1 29  PRO 29  9    9    PRO PRO A . n 
A 1 30  ARG 30  10   10   ARG ARG A . n 
A 1 31  VAL 31  11   11   VAL VAL A . n 
A 1 32  LYS 32  12   12   LYS LYS A . n 
A 1 33  ALA 33  13   13   ALA ALA A . n 
A 1 34  LEU 34  14   14   LEU LEU A . n 
A 1 35  ALA 35  15   15   ALA ALA A . n 
A 1 36  ALA 36  16   16   ALA ALA A . n 
A 1 37  LEU 37  17   17   LEU LEU A . n 
A 1 38  LYS 38  18   18   LYS LYS A . n 
A 1 39  GLU 39  19   19   GLU GLU A . n 
A 1 40  ARG 40  20   20   ARG ARG A . n 
A 1 41  LYS 41  21   21   LYS LYS A . n 
A 1 42  GLU 42  22   22   GLU GLU A . n 
A 1 43  ARG 43  23   23   ARG ARG A . n 
A 1 44  GLU 44  24   24   GLU GLU A . n 
A 1 45  ARG 45  25   25   ARG ARG A . n 
A 1 46  THR 46  26   26   THR THR A . n 
A 1 47  GLY 47  27   27   GLY GLY A . n 
A 1 48  ARG 48  28   28   ARG ARG A . n 
A 1 49  PHE 49  29   29   PHE PHE A . n 
A 1 50  LEU 50  30   30   LEU LEU A . n 
A 1 51  VAL 51  31   31   VAL VAL A . n 
A 1 52  GLU 52  32   32   GLU GLU A . n 
A 1 53  GLY 53  33   33   GLY GLY A . n 
A 1 54  ARG 54  34   34   ARG ARG A . n 
A 1 55  ARG 55  35   35   ARG ARG A . n 
A 1 56  GLU 56  36   36   GLU GLU A . n 
A 1 57  VAL 57  37   37   VAL VAL A . n 
A 1 58  GLU 58  38   38   GLU GLU A . n 
A 1 59  ARG 59  39   39   ARG ARG A . n 
A 1 60  ALA 60  40   40   ALA ALA A . n 
A 1 61  LEU 61  41   41   LEU LEU A . n 
A 1 62  GLU 62  42   42   GLU GLU A . n 
A 1 63  ALA 63  43   43   ALA ALA A . n 
A 1 64  GLY 64  44   44   GLY GLY A . n 
A 1 65  LEU 65  45   45   LEU LEU A . n 
A 1 66  SER 66  46   46   SER SER A . n 
A 1 67  LEU 67  47   47   LEU LEU A . n 
A 1 68  GLU 68  48   48   GLU GLU A . n 
A 1 69  THR 69  49   49   THR THR A . n 
A 1 70  LEU 70  50   50   LEU LEU A . n 
A 1 71  LEU 71  51   51   LEU LEU A . n 
A 1 72  LEU 72  52   52   LEU LEU A . n 
A 1 73  GLY 73  53   53   GLY GLY A . n 
A 1 74  PRO 74  54   54   PRO PRO A . n 
A 1 75  LYS 75  55   55   LYS LYS A . n 
A 1 76  ALA 76  56   56   ALA ALA A . n 
A 1 77  ARG 77  57   57   ARG ARG A . n 
A 1 78  PRO 78  58   58   PRO PRO A . n 
A 1 79  GLU 79  59   59   GLU GLU A . n 
A 1 80  ASP 80  60   60   ASP ASP A . n 
A 1 81  ARG 81  61   61   ARG ARG A . n 
A 1 82  ALA 82  62   62   ALA ALA A . n 
A 1 83  LEU 83  63   63   LEU LEU A . n 
A 1 84  ALA 84  64   64   ALA ALA A . n 
A 1 85  GLY 85  65   65   GLY GLY A . n 
A 1 86  GLY 86  66   66   GLY GLY A . n 
A 1 87  ALA 87  67   67   ALA ALA A . n 
A 1 88  GLU 88  68   68   GLU GLU A . n 
A 1 89  VAL 89  69   69   VAL VAL A . n 
A 1 90  LEU 90  70   70   LEU LEU A . n 
A 1 91  GLU 91  71   71   GLU GLU A . n 
A 1 92  LEU 92  72   72   LEU LEU A . n 
A 1 93  SER 93  73   73   SER SER A . n 
A 1 94  GLU 94  74   74   GLU GLU A . n 
A 1 95  ARG 95  75   75   ARG ARG A . n 
A 1 96  ALA 96  76   76   ALA ALA A . n 
A 1 97  LEU 97  77   77   LEU LEU A . n 
A 1 98  ALA 98  78   78   ALA ALA A . n 
A 1 99  ARG 99  79   79   ARG ARG A . n 
A 1 100 VAL 100 80   80   VAL VAL A . n 
A 1 101 SER 101 81   81   SER SER A . n 
A 1 102 ALA 102 82   82   ALA ALA A . n 
A 1 103 ARG 103 83   83   ARG ARG A . n 
A 1 104 GLU 104 84   84   GLU GLU A . n 
A 1 105 ASN 105 85   85   ASN ASN A . n 
A 1 106 PRO 106 86   86   PRO PRO A . n 
A 1 107 ALA 107 87   87   ALA ALA A . n 
A 1 108 GLN 108 88   88   GLN GLN A . n 
A 1 109 VAL 109 89   89   VAL VAL A . n 
A 1 110 LEU 110 90   90   LEU LEU A . n 
A 1 111 GLY 111 91   91   GLY GLY A . n 
A 1 112 VAL 112 92   92   VAL VAL A . n 
A 1 113 PHE 113 93   93   PHE PHE A . n 
A 1 114 ARG 114 94   94   ARG ARG A . n 
A 1 115 LEU 115 95   95   LEU LEU A . n 
A 1 116 PRO 116 96   96   PRO PRO A . n 
A 1 117 ARG 117 97   97   ARG ARG A . n 
A 1 118 ARG 118 98   98   ARG ARG A . n 
A 1 119 SER 119 99   99   SER SER A . n 
A 1 120 LEU 120 100  100  LEU LEU A . n 
A 1 121 ALA 121 101  101  ALA ALA A . n 
A 1 122 GLY 122 102  102  GLY GLY A . n 
A 1 123 VAL 123 103  103  VAL VAL A . n 
A 1 124 THR 124 104  104  THR THR A . n 
A 1 125 LEU 125 105  105  LEU LEU A . n 
A 1 126 GLY 126 106  106  GLY GLY A . n 
A 1 127 ALA 127 107  107  ALA ALA A . n 
A 1 128 ALA 128 108  108  ALA ALA A . n 
A 1 129 PRO 129 109  109  PRO PRO A . n 
A 1 130 LEU 130 110  110  LEU LEU A . n 
A 1 131 VAL 131 111  111  VAL VAL A . n 
A 1 132 LEU 132 112  112  LEU LEU A . n 
A 1 133 VAL 133 113  113  VAL VAL A . n 
A 1 134 LEU 134 114  114  LEU LEU A . n 
A 1 135 LEU 135 115  115  LEU LEU A . n 
A 1 136 GLY 136 116  116  GLY GLY A . n 
A 1 137 LEU 137 117  117  LEU LEU A . n 
A 1 138 GLU 138 118  118  GLU GLU A . n 
A 1 139 LYS 139 119  119  LYS LYS A . n 
A 1 140 PRO 140 120  120  PRO PRO A . n 
A 1 141 GLY 141 121  121  GLY GLY A . n 
A 1 142 ASN 142 122  122  ASN ASN A . n 
A 1 143 LEU 143 123  123  LEU LEU A . n 
A 1 144 GLY 144 124  124  GLY GLY A . n 
A 1 145 ALA 145 125  125  ALA ALA A . n 
A 1 146 ILE 146 126  126  ILE ILE A . n 
A 1 147 LEU 147 127  127  LEU LEU A . n 
A 1 148 ARG 148 128  128  ARG ARG A . n 
A 1 149 ALA 149 129  129  ALA ALA A . n 
A 1 150 ALA 150 130  130  ALA ALA A . n 
A 1 151 ASP 151 131  131  ASP ASP A . n 
A 1 152 GLY 152 132  132  GLY GLY A . n 
A 1 153 ALA 153 133  133  ALA ALA A . n 
A 1 154 GLY 154 134  134  GLY GLY A . n 
A 1 155 ALA 155 135  135  ALA ALA A . n 
A 1 156 ASP 156 136  136  ASP ASP A . n 
A 1 157 LEU 157 137  137  LEU LEU A . n 
A 1 158 VAL 158 138  138  VAL VAL A . n 
A 1 159 LEU 159 139  139  LEU LEU A . n 
A 1 160 VAL 160 140  140  VAL VAL A . n 
A 1 161 ALA 161 141  141  ALA ALA A . n 
A 1 162 GLU 162 142  142  GLU GLU A . n 
A 1 163 GLY 163 143  143  GLY GLY A . n 
A 1 164 VAL 164 144  144  VAL VAL A . n 
A 1 165 ASP 165 145  145  ASP ASP A . n 
A 1 166 LEU 166 146  146  LEU LEU A . n 
A 1 167 PHE 167 147  147  PHE PHE A . n 
A 1 168 SER 168 148  148  SER SER A . n 
A 1 169 PRO 169 149  149  PRO PRO A . n 
A 1 170 GLN 170 150  150  GLN GLN A . n 
A 1 171 VAL 171 151  151  VAL VAL A . n 
A 1 172 ILE 172 152  152  ILE ILE A . n 
A 1 173 ARG 173 153  153  ARG ARG A . n 
A 1 174 ASN 174 154  154  ASN ASN A . n 
A 1 175 SER 175 155  155  SER SER A . n 
A 1 176 THR 176 156  156  THR THR A . n 
A 1 177 GLY 177 157  157  GLY GLY A . n 
A 1 178 ALA 178 158  158  ALA ALA A . n 
A 1 179 VAL 179 159  159  VAL VAL A . n 
A 1 180 PHE 180 160  160  PHE PHE A . n 
A 1 181 ALA 181 161  161  ALA ALA A . n 
A 1 182 LEU 182 162  162  LEU LEU A . n 
A 1 183 PRO 183 163  163  PRO PRO A . n 
A 1 184 VAL 184 164  164  VAL VAL A . n 
A 1 185 TYR 185 165  165  TYR TYR A . n 
A 1 186 PRO 186 166  166  PRO PRO A . n 
A 1 187 VAL 187 167  167  VAL VAL A . n 
A 1 188 ALA 188 168  168  ALA ALA A . n 
A 1 189 GLU 189 169  169  GLU GLU A . n 
A 1 190 GLU 190 170  170  GLU GLU A . n 
A 1 191 GLU 191 171  171  GLU GLU A . n 
A 1 192 ALA 192 172  172  ALA ALA A . n 
A 1 193 ALA 193 173  173  ALA ALA A . n 
A 1 194 ARG 194 174  174  ARG ARG A . n 
A 1 195 PHE 195 175  175  PHE PHE A . n 
A 1 196 LEU 196 176  176  LEU LEU A . n 
A 1 197 GLU 197 177  177  GLU GLU A . n 
A 1 198 GLU 198 178  178  GLU GLU A . n 
A 1 199 GLN 199 179  179  GLN GLN A . n 
A 1 200 ASN 200 180  180  ASN ASN A . n 
A 1 201 LEU 201 181  181  LEU LEU A . n 
A 1 202 PRO 202 182  182  PRO PRO A . n 
A 1 203 LEU 203 183  183  LEU LEU A . n 
A 1 204 VAL 204 184  184  VAL VAL A . n 
A 1 205 ALA 205 185  185  ALA ALA A . n 
A 1 206 ALA 206 186  186  ALA ALA A . n 
A 1 207 THR 207 187  187  THR THR A . n 
A 1 208 PRO 208 188  188  PRO PRO A . n 
A 1 209 GLU 209 189  189  GLU GLU A . n 
A 1 210 GLY 210 190  190  GLY GLY A . n 
A 1 211 GLU 211 191  191  GLU GLU A . n 
A 1 212 ARG 212 192  192  ARG ARG A . n 
A 1 213 LEU 213 193  193  LEU LEU A . n 
A 1 214 TYR 214 194  194  TYR TYR A . n 
A 1 215 TRP 215 195  195  TRP TRP A . n 
A 1 216 GLU 216 196  196  GLU GLU A . n 
A 1 217 GLY 217 197  197  GLY GLY A . n 
A 1 218 ASP 218 198  198  ASP ASP A . n 
A 1 219 TYR 219 199  199  TYR TYR A . n 
A 1 220 ARG 220 200  200  ARG ARG A . n 
A 1 221 GLY 221 201  201  GLY GLY A . n 
A 1 222 GLY 222 202  202  GLY GLY A . n 
A 1 223 VAL 223 203  203  VAL VAL A . n 
A 1 224 ALA 224 204  204  ALA ALA A . n 
A 1 225 PHE 225 205  205  PHE PHE A . n 
A 1 226 LEU 226 206  206  LEU LEU A . n 
A 1 227 LEU 227 207  207  LEU LEU A . n 
A 1 228 GLY 228 208  208  GLY GLY A . n 
A 1 229 ALA 229 209  209  ALA ALA A . n 
A 1 230 GLU 230 210  210  GLU GLU A . n 
A 1 231 ASP 231 211  211  ASP ASP A . n 
A 1 232 LYS 232 212  212  LYS LYS A . n 
A 1 233 GLY 233 213  213  GLY GLY A . n 
A 1 234 LEU 234 214  214  LEU LEU A . n 
A 1 235 PRO 235 215  215  PRO PRO A . n 
A 1 236 GLU 236 216  216  GLU GLU A . n 
A 1 237 ALA 237 217  217  ALA ALA A . n 
A 1 238 TRP 238 218  218  TRP TRP A . n 
A 1 239 LYS 239 219  219  LYS LYS A . n 
A 1 240 ARG 240 220  220  ARG ARG A . n 
A 1 241 ARG 241 221  221  ARG ARG A . n 
A 1 242 ALA 242 222  222  ALA ALA A . n 
A 1 243 GLN 243 223  223  GLN GLN A . n 
A 1 244 VAL 244 224  224  VAL VAL A . n 
A 1 245 ARG 245 225  225  ARG ARG A . n 
A 1 246 VAL 246 226  226  VAL VAL A . n 
A 1 247 ARG 247 227  227  ARG ARG A . n 
A 1 248 ILE 248 228  228  ILE ILE A . n 
A 1 249 PRO 249 229  229  PRO PRO A . n 
A 1 250 MET 250 230  230  MET MET A . n 
A 1 251 ARG 251 231  231  ARG ARG A . n 
A 1 252 GLY 252 232  232  GLY GLY A . n 
A 1 253 ARG 253 233  233  ARG ARG A . n 
A 1 254 ALA 254 234  234  ALA ALA A . n 
A 1 255 ASP 255 235  235  ASP ASP A . n 
A 1 256 SER 256 236  236  SER SER A . n 
A 1 257 LEU 257 237  237  LEU LEU A . n 
A 1 258 ASN 258 238  238  ASN ASN A . n 
A 1 259 VAL 259 239  239  VAL VAL A . n 
A 1 260 ALA 260 240  240  ALA ALA A . n 
A 1 261 VAL 261 241  241  VAL VAL A . n 
A 1 262 THR 262 242  242  THR THR A . n 
A 1 263 ALA 263 243  243  ALA ALA A . n 
A 1 264 ALA 264 244  244  ALA ALA A . n 
A 1 265 LEU 265 245  245  LEU LEU A . n 
A 1 266 LEU 266 246  246  LEU LEU A . n 
A 1 267 LEU 267 247  247  LEU LEU A . n 
A 1 268 TYR 268 248  248  TYR TYR A . n 
A 1 269 GLU 269 249  249  GLU GLU A . n 
A 1 270 ALA 270 250  250  ALA ALA A . n 
A 1 271 LEU 271 251  251  LEU LEU A . n 
A 1 272 ARG 272 252  252  ARG ARG A . n 
A 1 273 GLN 273 253  253  GLN GLN A . n 
A 1 274 ARG 274 254  254  ARG ARG A . n 
A 1 275 SER 275 255  255  SER SER A . n 
A 1 276 GLY 276 256  256  GLY GLY A . n 
A 1 277 GLY 277 257  257  GLY GLY A . n 
A 1 278 ALA 278 258  258  ALA ALA A . n 
A 1 279 PRO 279 259  259  PRO PRO A . n 
A 1 280 LEU 280 260  260  LEU LEU A . n 
B 1 1   MET 1   -19  ?    ?   ?   B . n 
B 1 2   GLY 2   -18  ?    ?   ?   B . n 
B 1 3   SER 3   -17  ?    ?   ?   B . n 
B 1 4   SER 4   -16  ?    ?   ?   B . n 
B 1 5   HIS 5   -15  ?    ?   ?   B . n 
B 1 6   HIS 6   -14  ?    ?   ?   B . n 
B 1 7   HIS 7   -13  ?    ?   ?   B . n 
B 1 8   HIS 8   -12  ?    ?   ?   B . n 
B 1 9   HIS 9   -11  ?    ?   ?   B . n 
B 1 10  HIS 10  -10  ?    ?   ?   B . n 
B 1 11  SER 11  -9   ?    ?   ?   B . n 
B 1 12  SER 12  -8   ?    ?   ?   B . n 
B 1 13  GLY 13  -7   ?    ?   ?   B . n 
B 1 14  LEU 14  -6   ?    ?   ?   B . n 
B 1 15  VAL 15  -5   ?    ?   ?   B . n 
B 1 16  PRO 16  -4   ?    ?   ?   B . n 
B 1 17  ARG 17  -3   ?    ?   ?   B . n 
B 1 18  GLY 18  -2   ?    ?   ?   B . n 
B 1 19  SER 19  -1   ?    ?   ?   B . n 
B 1 20  HIS 20  0    ?    ?   ?   B . n 
B 1 21  MET 21  1    1    MET MET B . n 
B 1 22  ARG 22  2    2    ARG ARG B . n 
B 1 23  ILE 23  3    3    ILE ILE B . n 
B 1 24  GLU 24  4    4    GLU GLU B . n 
B 1 25  SER 25  5    5    SER SER B . n 
B 1 26  PRO 26  6    6    PRO PRO B . n 
B 1 27  GLN 27  7    7    GLN GLN B . n 
B 1 28  ASN 28  8    8    ASN ASN B . n 
B 1 29  PRO 29  9    9    PRO PRO B . n 
B 1 30  ARG 30  10   10   ARG ARG B . n 
B 1 31  VAL 31  11   11   VAL VAL B . n 
B 1 32  LYS 32  12   12   LYS LYS B . n 
B 1 33  ALA 33  13   13   ALA ALA B . n 
B 1 34  LEU 34  14   14   LEU LEU B . n 
B 1 35  ALA 35  15   15   ALA ALA B . n 
B 1 36  ALA 36  16   16   ALA ALA B . n 
B 1 37  LEU 37  17   17   LEU LEU B . n 
B 1 38  LYS 38  18   18   LYS LYS B . n 
B 1 39  GLU 39  19   19   GLU GLU B . n 
B 1 40  ARG 40  20   20   ARG ARG B . n 
B 1 41  LYS 41  21   21   LYS LYS B . n 
B 1 42  GLU 42  22   22   GLU GLU B . n 
B 1 43  ARG 43  23   23   ARG ARG B . n 
B 1 44  GLU 44  24   24   GLU GLU B . n 
B 1 45  ARG 45  25   25   ARG ARG B . n 
B 1 46  THR 46  26   26   THR THR B . n 
B 1 47  GLY 47  27   27   GLY GLY B . n 
B 1 48  ARG 48  28   28   ARG ARG B . n 
B 1 49  PHE 49  29   29   PHE PHE B . n 
B 1 50  LEU 50  30   30   LEU LEU B . n 
B 1 51  VAL 51  31   31   VAL VAL B . n 
B 1 52  GLU 52  32   32   GLU GLU B . n 
B 1 53  GLY 53  33   33   GLY GLY B . n 
B 1 54  ARG 54  34   34   ARG ARG B . n 
B 1 55  ARG 55  35   35   ARG ARG B . n 
B 1 56  GLU 56  36   36   GLU GLU B . n 
B 1 57  VAL 57  37   37   VAL VAL B . n 
B 1 58  GLU 58  38   38   GLU GLU B . n 
B 1 59  ARG 59  39   39   ARG ARG B . n 
B 1 60  ALA 60  40   40   ALA ALA B . n 
B 1 61  LEU 61  41   41   LEU LEU B . n 
B 1 62  GLU 62  42   42   GLU GLU B . n 
B 1 63  ALA 63  43   43   ALA ALA B . n 
B 1 64  GLY 64  44   44   GLY GLY B . n 
B 1 65  LEU 65  45   45   LEU LEU B . n 
B 1 66  SER 66  46   46   SER SER B . n 
B 1 67  LEU 67  47   47   LEU LEU B . n 
B 1 68  GLU 68  48   48   GLU GLU B . n 
B 1 69  THR 69  49   49   THR THR B . n 
B 1 70  LEU 70  50   50   LEU LEU B . n 
B 1 71  LEU 71  51   51   LEU LEU B . n 
B 1 72  LEU 72  52   52   LEU LEU B . n 
B 1 73  GLY 73  53   53   GLY GLY B . n 
B 1 74  PRO 74  54   54   PRO PRO B . n 
B 1 75  LYS 75  55   55   LYS LYS B . n 
B 1 76  ALA 76  56   56   ALA ALA B . n 
B 1 77  ARG 77  57   57   ARG ARG B . n 
B 1 78  PRO 78  58   58   PRO PRO B . n 
B 1 79  GLU 79  59   59   GLU GLU B . n 
B 1 80  ASP 80  60   60   ASP ASP B . n 
B 1 81  ARG 81  61   61   ARG ARG B . n 
B 1 82  ALA 82  62   62   ALA ALA B . n 
B 1 83  LEU 83  63   63   LEU LEU B . n 
B 1 84  ALA 84  64   64   ALA ALA B . n 
B 1 85  GLY 85  65   65   GLY GLY B . n 
B 1 86  GLY 86  66   66   GLY GLY B . n 
B 1 87  ALA 87  67   67   ALA ALA B . n 
B 1 88  GLU 88  68   68   GLU GLU B . n 
B 1 89  VAL 89  69   69   VAL VAL B . n 
B 1 90  LEU 90  70   70   LEU LEU B . n 
B 1 91  GLU 91  71   71   GLU GLU B . n 
B 1 92  LEU 92  72   72   LEU LEU B . n 
B 1 93  SER 93  73   73   SER SER B . n 
B 1 94  GLU 94  74   74   GLU GLU B . n 
B 1 95  ARG 95  75   75   ARG ARG B . n 
B 1 96  ALA 96  76   76   ALA ALA B . n 
B 1 97  LEU 97  77   77   LEU LEU B . n 
B 1 98  ALA 98  78   78   ALA ALA B . n 
B 1 99  ARG 99  79   79   ARG ARG B . n 
B 1 100 VAL 100 80   80   VAL VAL B . n 
B 1 101 SER 101 81   81   SER SER B . n 
B 1 102 ALA 102 82   82   ALA ALA B . n 
B 1 103 ARG 103 83   83   ARG ARG B . n 
B 1 104 GLU 104 84   84   GLU GLU B . n 
B 1 105 ASN 105 85   85   ASN ASN B . n 
B 1 106 PRO 106 86   86   PRO PRO B . n 
B 1 107 ALA 107 87   87   ALA ALA B . n 
B 1 108 GLN 108 88   88   GLN GLN B . n 
B 1 109 VAL 109 89   89   VAL VAL B . n 
B 1 110 LEU 110 90   90   LEU LEU B . n 
B 1 111 GLY 111 91   91   GLY GLY B . n 
B 1 112 VAL 112 92   92   VAL VAL B . n 
B 1 113 PHE 113 93   93   PHE PHE B . n 
B 1 114 ARG 114 94   94   ARG ARG B . n 
B 1 115 LEU 115 95   95   LEU LEU B . n 
B 1 116 PRO 116 96   96   PRO PRO B . n 
B 1 117 ARG 117 97   97   ARG ARG B . n 
B 1 118 ARG 118 98   98   ARG ARG B . n 
B 1 119 SER 119 99   99   SER SER B . n 
B 1 120 LEU 120 100  100  LEU LEU B . n 
B 1 121 ALA 121 101  101  ALA ALA B . n 
B 1 122 GLY 122 102  102  GLY GLY B . n 
B 1 123 VAL 123 103  103  VAL VAL B . n 
B 1 124 THR 124 104  104  THR THR B . n 
B 1 125 LEU 125 105  105  LEU LEU B . n 
B 1 126 GLY 126 106  106  GLY GLY B . n 
B 1 127 ALA 127 107  107  ALA ALA B . n 
B 1 128 ALA 128 108  108  ALA ALA B . n 
B 1 129 PRO 129 109  109  PRO PRO B . n 
B 1 130 LEU 130 110  110  LEU LEU B . n 
B 1 131 VAL 131 111  111  VAL VAL B . n 
B 1 132 LEU 132 112  112  LEU LEU B . n 
B 1 133 VAL 133 113  113  VAL VAL B . n 
B 1 134 LEU 134 114  114  LEU LEU B . n 
B 1 135 LEU 135 115  115  LEU LEU B . n 
B 1 136 GLY 136 116  116  GLY GLY B . n 
B 1 137 LEU 137 117  117  LEU LEU B . n 
B 1 138 GLU 138 118  118  GLU GLU B . n 
B 1 139 LYS 139 119  119  LYS LYS B . n 
B 1 140 PRO 140 120  120  PRO PRO B . n 
B 1 141 GLY 141 121  121  GLY GLY B . n 
B 1 142 ASN 142 122  122  ASN ASN B . n 
B 1 143 LEU 143 123  123  LEU LEU B . n 
B 1 144 GLY 144 124  124  GLY GLY B . n 
B 1 145 ALA 145 125  125  ALA ALA B . n 
B 1 146 ILE 146 126  126  ILE ILE B . n 
B 1 147 LEU 147 127  127  LEU LEU B . n 
B 1 148 ARG 148 128  128  ARG ARG B . n 
B 1 149 ALA 149 129  129  ALA ALA B . n 
B 1 150 ALA 150 130  130  ALA ALA B . n 
B 1 151 ASP 151 131  131  ASP ASP B . n 
B 1 152 GLY 152 132  132  GLY GLY B . n 
B 1 153 ALA 153 133  133  ALA ALA B . n 
B 1 154 GLY 154 134  134  GLY GLY B . n 
B 1 155 ALA 155 135  135  ALA ALA B . n 
B 1 156 ASP 156 136  136  ASP ASP B . n 
B 1 157 LEU 157 137  137  LEU LEU B . n 
B 1 158 VAL 158 138  138  VAL VAL B . n 
B 1 159 LEU 159 139  139  LEU LEU B . n 
B 1 160 VAL 160 140  140  VAL VAL B . n 
B 1 161 ALA 161 141  141  ALA ALA B . n 
B 1 162 GLU 162 142  142  GLU GLU B . n 
B 1 163 GLY 163 143  143  GLY GLY B . n 
B 1 164 VAL 164 144  144  VAL VAL B . n 
B 1 165 ASP 165 145  145  ASP ASP B . n 
B 1 166 LEU 166 146  146  LEU LEU B . n 
B 1 167 PHE 167 147  147  PHE PHE B . n 
B 1 168 SER 168 148  148  SER SER B . n 
B 1 169 PRO 169 149  149  PRO PRO B . n 
B 1 170 GLN 170 150  150  GLN GLN B . n 
B 1 171 VAL 171 151  151  VAL VAL B . n 
B 1 172 ILE 172 152  152  ILE ILE B . n 
B 1 173 ARG 173 153  153  ARG ARG B . n 
B 1 174 ASN 174 154  154  ASN ASN B . n 
B 1 175 SER 175 155  155  SER SER B . n 
B 1 176 THR 176 156  156  THR THR B . n 
B 1 177 GLY 177 157  157  GLY GLY B . n 
B 1 178 ALA 178 158  158  ALA ALA B . n 
B 1 179 VAL 179 159  159  VAL VAL B . n 
B 1 180 PHE 180 160  160  PHE PHE B . n 
B 1 181 ALA 181 161  161  ALA ALA B . n 
B 1 182 LEU 182 162  162  LEU LEU B . n 
B 1 183 PRO 183 163  163  PRO PRO B . n 
B 1 184 VAL 184 164  164  VAL VAL B . n 
B 1 185 TYR 185 165  165  TYR TYR B . n 
B 1 186 PRO 186 166  166  PRO PRO B . n 
B 1 187 VAL 187 167  167  VAL VAL B . n 
B 1 188 ALA 188 168  168  ALA ALA B . n 
B 1 189 GLU 189 169  169  GLU GLU B . n 
B 1 190 GLU 190 170  170  GLU GLU B . n 
B 1 191 GLU 191 171  171  GLU GLU B . n 
B 1 192 ALA 192 172  172  ALA ALA B . n 
B 1 193 ALA 193 173  173  ALA ALA B . n 
B 1 194 ARG 194 174  174  ARG ARG B . n 
B 1 195 PHE 195 175  175  PHE PHE B . n 
B 1 196 LEU 196 176  176  LEU LEU B . n 
B 1 197 GLU 197 177  177  GLU GLU B . n 
B 1 198 GLU 198 178  178  GLU GLU B . n 
B 1 199 GLN 199 179  179  GLN GLN B . n 
B 1 200 ASN 200 180  180  ASN ASN B . n 
B 1 201 LEU 201 181  181  LEU LEU B . n 
B 1 202 PRO 202 182  182  PRO PRO B . n 
B 1 203 LEU 203 183  183  LEU LEU B . n 
B 1 204 VAL 204 184  184  VAL VAL B . n 
B 1 205 ALA 205 185  185  ALA ALA B . n 
B 1 206 ALA 206 186  186  ALA ALA B . n 
B 1 207 THR 207 187  187  THR THR B . n 
B 1 208 PRO 208 188  188  PRO PRO B . n 
B 1 209 GLU 209 189  189  GLU GLU B . n 
B 1 210 GLY 210 190  190  GLY GLY B . n 
B 1 211 GLU 211 191  191  GLU GLU B . n 
B 1 212 ARG 212 192  192  ARG ARG B . n 
B 1 213 LEU 213 193  193  LEU LEU B . n 
B 1 214 TYR 214 194  194  TYR TYR B . n 
B 1 215 TRP 215 195  195  TRP TRP B . n 
B 1 216 GLU 216 196  196  GLU GLU B . n 
B 1 217 GLY 217 197  197  GLY GLY B . n 
B 1 218 ASP 218 198  198  ASP ASP B . n 
B 1 219 TYR 219 199  199  TYR TYR B . n 
B 1 220 ARG 220 200  200  ARG ARG B . n 
B 1 221 GLY 221 201  201  GLY GLY B . n 
B 1 222 GLY 222 202  202  GLY GLY B . n 
B 1 223 VAL 223 203  203  VAL VAL B . n 
B 1 224 ALA 224 204  204  ALA ALA B . n 
B 1 225 PHE 225 205  205  PHE PHE B . n 
B 1 226 LEU 226 206  206  LEU LEU B . n 
B 1 227 LEU 227 207  207  LEU LEU B . n 
B 1 228 GLY 228 208  208  GLY GLY B . n 
B 1 229 ALA 229 209  209  ALA ALA B . n 
B 1 230 GLU 230 210  210  GLU GLU B . n 
B 1 231 ASP 231 211  211  ASP ASP B . n 
B 1 232 LYS 232 212  212  LYS LYS B . n 
B 1 233 GLY 233 213  213  GLY GLY B . n 
B 1 234 LEU 234 214  214  LEU LEU B . n 
B 1 235 PRO 235 215  215  PRO PRO B . n 
B 1 236 GLU 236 216  216  GLU GLU B . n 
B 1 237 ALA 237 217  217  ALA ALA B . n 
B 1 238 TRP 238 218  218  TRP TRP B . n 
B 1 239 LYS 239 219  219  LYS LYS B . n 
B 1 240 ARG 240 220  220  ARG ARG B . n 
B 1 241 ARG 241 221  221  ARG ARG B . n 
B 1 242 ALA 242 222  222  ALA ALA B . n 
B 1 243 GLN 243 223  223  GLN GLN B . n 
B 1 244 VAL 244 224  224  VAL VAL B . n 
B 1 245 ARG 245 225  225  ARG ARG B . n 
B 1 246 VAL 246 226  226  VAL VAL B . n 
B 1 247 ARG 247 227  227  ARG ARG B . n 
B 1 248 ILE 248 228  228  ILE ILE B . n 
B 1 249 PRO 249 229  229  PRO PRO B . n 
B 1 250 MET 250 230  230  MET MET B . n 
B 1 251 ARG 251 231  231  ARG ARG B . n 
B 1 252 GLY 252 232  232  GLY GLY B . n 
B 1 253 ARG 253 233  233  ARG ARG B . n 
B 1 254 ALA 254 234  234  ALA ALA B . n 
B 1 255 ASP 255 235  235  ASP ASP B . n 
B 1 256 SER 256 236  236  SER SER B . n 
B 1 257 LEU 257 237  237  LEU LEU B . n 
B 1 258 ASN 258 238  238  ASN ASN B . n 
B 1 259 VAL 259 239  239  VAL VAL B . n 
B 1 260 ALA 260 240  240  ALA ALA B . n 
B 1 261 VAL 261 241  241  VAL VAL B . n 
B 1 262 THR 262 242  242  THR THR B . n 
B 1 263 ALA 263 243  243  ALA ALA B . n 
B 1 264 ALA 264 244  244  ALA ALA B . n 
B 1 265 LEU 265 245  245  LEU LEU B . n 
B 1 266 LEU 266 246  246  LEU LEU B . n 
B 1 267 LEU 267 247  247  LEU LEU B . n 
B 1 268 TYR 268 248  248  TYR TYR B . n 
B 1 269 GLU 269 249  249  GLU GLU B . n 
B 1 270 ALA 270 250  250  ALA ALA B . n 
B 1 271 LEU 271 251  251  LEU LEU B . n 
B 1 272 ARG 272 252  252  ARG ARG B . n 
B 1 273 GLN 273 253  253  GLN GLN B . n 
B 1 274 ARG 274 254  254  ARG ARG B . n 
B 1 275 SER 275 255  255  SER SER B . n 
B 1 276 GLY 276 256  256  GLY GLY B . n 
B 1 277 GLY 277 257  257  GLY GLY B . n 
B 1 278 ALA 278 258  258  ALA ALA B . n 
B 1 279 PRO 279 259  259  PRO PRO B . n 
B 1 280 LEU 280 260  260  LEU LEU B . n 
C 2 1   G   1   2513 2513 G   G   C . n 
C 2 2   U   2   2514 2514 U   U   C . n 
C 2 3   C   3   2515 2515 C   C   C . n 
C 2 4   G   4   2516 2516 G   G   C . n 
C 2 5   C   5   2517 2517 C   C   C . n 
C 2 6   A   6   2518 2518 A   A   C . n 
C 2 7   U   7   2519 2519 U   U   C . n 
C 2 8   C   8   2520 2520 C   C   C . n 
C 2 9   C   9   2521 2521 C   C   C . n 
C 2 10  U   10  2522 2522 U   U   C . n 
C 2 11  G   11  2523 ?    ?   ?   C . n 
C 2 12  G   12  2524 ?    ?   ?   C . n 
C 2 13  G   13  2525 ?    ?   ?   C . n 
C 2 14  G   14  2526 ?    ?   ?   C . n 
C 2 15  C   15  2527 ?    ?   ?   C . n 
C 2 16  U   16  2528 ?    ?   ?   C . n 
C 2 17  G   17  2529 ?    ?   ?   C . n 
C 2 18  A   18  2530 ?    ?   ?   C . n 
C 2 19  A   19  2531 ?    ?   ?   C . n 
C 2 20  G   20  2532 ?    ?   ?   C . n 
C 2 21  A   21  2533 ?    ?   ?   C . n 
C 2 22  A   22  2534 ?    ?   ?   C . n 
C 2 23  G   23  2535 ?    ?   ?   C . n 
C 2 24  G   24  2536 ?    ?   ?   C . n 
C 2 25  U   25  2537 ?    ?   ?   C . n 
C 2 26  C   26  2538 ?    ?   ?   C . n 
C 2 27  C   27  2539 ?    ?   ?   C . n 
C 2 28  C   28  2540 ?    ?   ?   C . n 
C 2 29  A   29  2541 ?    ?   ?   C . n 
C 2 30  A   30  2542 ?    ?   ?   C . n 
C 2 31  G   31  2543 2543 G   G   C . n 
C 2 32  G   32  2544 2544 G   G   C . n 
C 2 33  G   33  2545 2545 G   G   C . n 
C 2 34  U   34  2546 2546 U   U   C . n 
C 2 35  U   35  2547 2547 U   U   C . n 
C 2 36  G   36  2548 2548 G   G   C . n 
C 2 37  G   37  2549 2549 G   G   C . n 
C 2 38  G   38  2550 2550 G   G   C . n 
C 2 39  C   39  2551 2551 C   C   C . n 
C 2 40  U   40  2552 2552 U   U   C . n 
C 2 41  G   41  2553 2553 G   G   C . n 
C 2 42  U   42  2554 2554 U   U   C . n 
C 2 43  U   43  2555 2555 U   U   C . n 
C 2 44  C   44  2556 2556 C   C   C . n 
C 2 45  G   45  2557 2557 G   G   C . n 
C 2 46  C   46  2558 2558 C   C   C . n 
C 2 47  C   47  2559 2559 C   C   C . n 
C 2 48  C   48  2560 2560 C   C   C . n 
C 2 49  A   49  2561 2561 A   A   C . n 
C 2 50  U   50  2562 2562 U   U   C . n 
C 2 51  U   51  2563 2563 U   U   C . n 
C 2 52  A   52  2564 ?    ?   ?   C . n 
C 2 53  A   53  2565 ?    ?   ?   C . n 
C 2 54  A   54  2566 ?    ?   ?   C . n 
C 2 55  G   55  2567 2567 G   G   C . n 
C 2 56  C   56  2568 2568 C   C   C . n 
C 2 57  G   57  2569 2569 G   G   C . n 
C 2 58  G   58  2570 2570 G   G   C . n 
C 2 59  C   59  2571 2571 C   C   C . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        SAH 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   SAH 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
D 3 SAH 1   301  301 SAH SAH A . 
E 3 SAH 1   301  301 SAH SAH B . 
F 4 HOH 1   401  219 HOH HOH A . 
F 4 HOH 2   402  499 HOH HOH A . 
F 4 HOH 3   403  314 HOH HOH A . 
F 4 HOH 4   404  165 HOH HOH A . 
F 4 HOH 5   405  30  HOH HOH A . 
F 4 HOH 6   406  218 HOH HOH A . 
F 4 HOH 7   407  497 HOH HOH A . 
F 4 HOH 8   408  114 HOH HOH A . 
F 4 HOH 9   409  123 HOH HOH A . 
F 4 HOH 10  410  148 HOH HOH A . 
F 4 HOH 11  411  490 HOH HOH A . 
F 4 HOH 12  412  263 HOH HOH A . 
F 4 HOH 13  413  340 HOH HOH A . 
F 4 HOH 14  414  457 HOH HOH A . 
F 4 HOH 15  415  361 HOH HOH A . 
F 4 HOH 16  416  206 HOH HOH A . 
F 4 HOH 17  417  100 HOH HOH A . 
F 4 HOH 18  418  373 HOH HOH A . 
F 4 HOH 19  419  101 HOH HOH A . 
F 4 HOH 20  420  160 HOH HOH A . 
F 4 HOH 21  421  129 HOH HOH A . 
F 4 HOH 22  422  143 HOH HOH A . 
F 4 HOH 23  423  501 HOH HOH A . 
F 4 HOH 24  424  525 HOH HOH A . 
F 4 HOH 25  425  279 HOH HOH A . 
F 4 HOH 26  426  553 HOH HOH A . 
F 4 HOH 27  427  543 HOH HOH A . 
F 4 HOH 28  428  480 HOH HOH A . 
F 4 HOH 29  429  454 HOH HOH A . 
F 4 HOH 30  430  577 HOH HOH A . 
F 4 HOH 31  431  41  HOH HOH A . 
F 4 HOH 32  432  175 HOH HOH A . 
F 4 HOH 33  433  27  HOH HOH A . 
F 4 HOH 34  434  45  HOH HOH A . 
F 4 HOH 35  435  190 HOH HOH A . 
F 4 HOH 36  436  207 HOH HOH A . 
F 4 HOH 37  437  538 HOH HOH A . 
F 4 HOH 38  438  172 HOH HOH A . 
F 4 HOH 39  439  82  HOH HOH A . 
F 4 HOH 40  440  306 HOH HOH A . 
F 4 HOH 41  441  4   HOH HOH A . 
F 4 HOH 42  442  393 HOH HOH A . 
F 4 HOH 43  443  186 HOH HOH A . 
F 4 HOH 44  444  274 HOH HOH A . 
F 4 HOH 45  445  365 HOH HOH A . 
F 4 HOH 46  446  5   HOH HOH A . 
F 4 HOH 47  447  42  HOH HOH A . 
F 4 HOH 48  448  500 HOH HOH A . 
F 4 HOH 49  449  315 HOH HOH A . 
F 4 HOH 50  450  140 HOH HOH A . 
F 4 HOH 51  451  34  HOH HOH A . 
F 4 HOH 52  452  298 HOH HOH A . 
F 4 HOH 53  453  464 HOH HOH A . 
F 4 HOH 54  454  185 HOH HOH A . 
F 4 HOH 55  455  418 HOH HOH A . 
F 4 HOH 56  456  352 HOH HOH A . 
F 4 HOH 57  457  286 HOH HOH A . 
F 4 HOH 58  458  50  HOH HOH A . 
F 4 HOH 59  459  110 HOH HOH A . 
F 4 HOH 60  460  569 HOH HOH A . 
F 4 HOH 61  461  80  HOH HOH A . 
F 4 HOH 62  462  39  HOH HOH A . 
F 4 HOH 63  463  48  HOH HOH A . 
F 4 HOH 64  464  571 HOH HOH A . 
F 4 HOH 65  465  558 HOH HOH A . 
F 4 HOH 66  466  313 HOH HOH A . 
F 4 HOH 67  467  8   HOH HOH A . 
F 4 HOH 68  468  3   HOH HOH A . 
F 4 HOH 69  469  394 HOH HOH A . 
F 4 HOH 70  470  112 HOH HOH A . 
F 4 HOH 71  471  258 HOH HOH A . 
F 4 HOH 72  472  332 HOH HOH A . 
F 4 HOH 73  473  99  HOH HOH A . 
F 4 HOH 74  474  55  HOH HOH A . 
F 4 HOH 75  475  81  HOH HOH A . 
F 4 HOH 76  476  420 HOH HOH A . 
F 4 HOH 77  477  255 HOH HOH A . 
F 4 HOH 78  478  339 HOH HOH A . 
F 4 HOH 79  479  137 HOH HOH A . 
F 4 HOH 80  480  565 HOH HOH A . 
F 4 HOH 81  481  542 HOH HOH A . 
F 4 HOH 82  482  220 HOH HOH A . 
F 4 HOH 83  483  300 HOH HOH A . 
F 4 HOH 84  484  17  HOH HOH A . 
F 4 HOH 85  485  346 HOH HOH A . 
F 4 HOH 86  486  245 HOH HOH A . 
F 4 HOH 87  487  216 HOH HOH A . 
F 4 HOH 88  488  390 HOH HOH A . 
F 4 HOH 89  489  496 HOH HOH A . 
F 4 HOH 90  490  146 HOH HOH A . 
F 4 HOH 91  491  289 HOH HOH A . 
F 4 HOH 92  492  115 HOH HOH A . 
F 4 HOH 93  493  445 HOH HOH A . 
F 4 HOH 94  494  578 HOH HOH A . 
F 4 HOH 95  495  392 HOH HOH A . 
F 4 HOH 96  496  85  HOH HOH A . 
F 4 HOH 97  497  23  HOH HOH A . 
F 4 HOH 98  498  91  HOH HOH A . 
F 4 HOH 99  499  539 HOH HOH A . 
F 4 HOH 100 500  31  HOH HOH A . 
F 4 HOH 101 501  145 HOH HOH A . 
F 4 HOH 102 502  362 HOH HOH A . 
F 4 HOH 103 503  292 HOH HOH A . 
F 4 HOH 104 504  16  HOH HOH A . 
F 4 HOH 105 505  58  HOH HOH A . 
F 4 HOH 106 506  227 HOH HOH A . 
F 4 HOH 107 507  189 HOH HOH A . 
F 4 HOH 108 508  136 HOH HOH A . 
F 4 HOH 109 509  153 HOH HOH A . 
F 4 HOH 110 510  583 HOH HOH A . 
F 4 HOH 111 511  13  HOH HOH A . 
F 4 HOH 112 512  20  HOH HOH A . 
F 4 HOH 113 513  211 HOH HOH A . 
F 4 HOH 114 514  183 HOH HOH A . 
F 4 HOH 115 515  83  HOH HOH A . 
F 4 HOH 116 516  268 HOH HOH A . 
F 4 HOH 117 517  198 HOH HOH A . 
F 4 HOH 118 518  56  HOH HOH A . 
F 4 HOH 119 519  22  HOH HOH A . 
F 4 HOH 120 520  478 HOH HOH A . 
F 4 HOH 121 521  453 HOH HOH A . 
F 4 HOH 122 522  244 HOH HOH A . 
F 4 HOH 123 523  301 HOH HOH A . 
F 4 HOH 124 524  92  HOH HOH A . 
F 4 HOH 125 525  584 HOH HOH A . 
F 4 HOH 126 526  523 HOH HOH A . 
F 4 HOH 127 527  124 HOH HOH A . 
F 4 HOH 128 528  225 HOH HOH A . 
F 4 HOH 129 529  229 HOH HOH A . 
F 4 HOH 130 530  71  HOH HOH A . 
F 4 HOH 131 531  191 HOH HOH A . 
F 4 HOH 132 532  21  HOH HOH A . 
F 4 HOH 133 533  51  HOH HOH A . 
F 4 HOH 134 534  180 HOH HOH A . 
F 4 HOH 135 535  360 HOH HOH A . 
F 4 HOH 136 536  357 HOH HOH A . 
F 4 HOH 137 537  551 HOH HOH A . 
F 4 HOH 138 538  217 HOH HOH A . 
F 4 HOH 139 539  33  HOH HOH A . 
F 4 HOH 140 540  579 HOH HOH A . 
F 4 HOH 141 541  253 HOH HOH A . 
F 4 HOH 142 542  271 HOH HOH A . 
F 4 HOH 143 543  178 HOH HOH A . 
F 4 HOH 144 544  491 HOH HOH A . 
F 4 HOH 145 545  455 HOH HOH A . 
F 4 HOH 146 546  144 HOH HOH A . 
F 4 HOH 147 547  582 HOH HOH A . 
F 4 HOH 148 548  284 HOH HOH A . 
F 4 HOH 149 549  97  HOH HOH A . 
F 4 HOH 150 550  259 HOH HOH A . 
F 4 HOH 151 551  224 HOH HOH A . 
F 4 HOH 152 552  1   HOH HOH A . 
F 4 HOH 153 553  170 HOH HOH A . 
F 4 HOH 154 554  15  HOH HOH A . 
F 4 HOH 155 555  330 HOH HOH A . 
F 4 HOH 156 556  561 HOH HOH A . 
F 4 HOH 157 557  407 HOH HOH A . 
F 4 HOH 158 558  335 HOH HOH A . 
F 4 HOH 159 559  409 HOH HOH A . 
F 4 HOH 160 560  452 HOH HOH A . 
F 4 HOH 161 561  537 HOH HOH A . 
F 4 HOH 162 562  560 HOH HOH A . 
F 4 HOH 163 563  222 HOH HOH A . 
F 4 HOH 164 564  559 HOH HOH A . 
F 4 HOH 165 565  533 HOH HOH A . 
F 4 HOH 166 566  90  HOH HOH A . 
F 4 HOH 167 567  421 HOH HOH A . 
F 4 HOH 168 568  581 HOH HOH A . 
F 4 HOH 169 569  347 HOH HOH A . 
F 4 HOH 170 570  316 HOH HOH A . 
F 4 HOH 171 571  444 HOH HOH A . 
F 4 HOH 172 572  467 HOH HOH A . 
F 4 HOH 173 573  572 HOH HOH A . 
F 4 HOH 174 574  317 HOH HOH A . 
F 4 HOH 175 575  226 HOH HOH A . 
F 4 HOH 176 576  147 HOH HOH A . 
F 4 HOH 177 577  570 HOH HOH A . 
F 4 HOH 178 578  563 HOH HOH A . 
F 4 HOH 179 579  549 HOH HOH A . 
F 4 HOH 180 580  282 HOH HOH A . 
F 4 HOH 181 581  379 HOH HOH A . 
F 4 HOH 182 582  371 HOH HOH A . 
F 4 HOH 183 583  184 HOH HOH A . 
F 4 HOH 184 584  517 HOH HOH A . 
F 4 HOH 185 585  540 HOH HOH A . 
F 4 HOH 186 586  349 HOH HOH A . 
F 4 HOH 187 587  199 HOH HOH A . 
F 4 HOH 188 588  395 HOH HOH A . 
F 4 HOH 189 589  108 HOH HOH A . 
F 4 HOH 190 590  251 HOH HOH A . 
F 4 HOH 191 591  195 HOH HOH A . 
F 4 HOH 192 592  285 HOH HOH A . 
F 4 HOH 193 593  382 HOH HOH A . 
F 4 HOH 194 594  338 HOH HOH A . 
F 4 HOH 195 595  341 HOH HOH A . 
F 4 HOH 196 596  554 HOH HOH A . 
F 4 HOH 197 597  387 HOH HOH A . 
F 4 HOH 198 598  566 HOH HOH A . 
F 4 HOH 199 599  541 HOH HOH A . 
G 4 HOH 1   401  302 HOH HOH B . 
G 4 HOH 2   402  252 HOH HOH B . 
G 4 HOH 3   403  200 HOH HOH B . 
G 4 HOH 4   404  266 HOH HOH B . 
G 4 HOH 5   405  127 HOH HOH B . 
G 4 HOH 6   406  516 HOH HOH B . 
G 4 HOH 7   407  204 HOH HOH B . 
G 4 HOH 8   408  89  HOH HOH B . 
G 4 HOH 9   409  461 HOH HOH B . 
G 4 HOH 10  410  240 HOH HOH B . 
G 4 HOH 11  411  323 HOH HOH B . 
G 4 HOH 12  412  141 HOH HOH B . 
G 4 HOH 13  413  242 HOH HOH B . 
G 4 HOH 14  414  519 HOH HOH B . 
G 4 HOH 15  415  545 HOH HOH B . 
G 4 HOH 16  416  522 HOH HOH B . 
G 4 HOH 17  417  168 HOH HOH B . 
G 4 HOH 18  418  502 HOH HOH B . 
G 4 HOH 19  419  158 HOH HOH B . 
G 4 HOH 20  420  104 HOH HOH B . 
G 4 HOH 21  421  54  HOH HOH B . 
G 4 HOH 22  422  193 HOH HOH B . 
G 4 HOH 23  423  96  HOH HOH B . 
G 4 HOH 24  424  86  HOH HOH B . 
G 4 HOH 25  425  415 HOH HOH B . 
G 4 HOH 26  426  456 HOH HOH B . 
G 4 HOH 27  427  122 HOH HOH B . 
G 4 HOH 28  428  197 HOH HOH B . 
G 4 HOH 29  429  351 HOH HOH B . 
G 4 HOH 30  430  250 HOH HOH B . 
G 4 HOH 31  431  52  HOH HOH B . 
G 4 HOH 32  432  280 HOH HOH B . 
G 4 HOH 33  433  95  HOH HOH B . 
G 4 HOH 34  434  157 HOH HOH B . 
G 4 HOH 35  435  239 HOH HOH B . 
G 4 HOH 36  436  291 HOH HOH B . 
G 4 HOH 37  437  256 HOH HOH B . 
G 4 HOH 38  438  449 HOH HOH B . 
G 4 HOH 39  439  14  HOH HOH B . 
G 4 HOH 40  440  125 HOH HOH B . 
G 4 HOH 41  441  62  HOH HOH B . 
G 4 HOH 42  442  63  HOH HOH B . 
G 4 HOH 43  443  106 HOH HOH B . 
G 4 HOH 44  444  72  HOH HOH B . 
G 4 HOH 45  445  2   HOH HOH B . 
G 4 HOH 46  446  552 HOH HOH B . 
G 4 HOH 47  447  6   HOH HOH B . 
G 4 HOH 48  448  241 HOH HOH B . 
G 4 HOH 49  449  59  HOH HOH B . 
G 4 HOH 50  450  28  HOH HOH B . 
G 4 HOH 51  451  221 HOH HOH B . 
G 4 HOH 52  452  116 HOH HOH B . 
G 4 HOH 53  453  520 HOH HOH B . 
G 4 HOH 54  454  567 HOH HOH B . 
G 4 HOH 55  455  308 HOH HOH B . 
G 4 HOH 56  456  43  HOH HOH B . 
G 4 HOH 57  457  64  HOH HOH B . 
G 4 HOH 58  458  155 HOH HOH B . 
G 4 HOH 59  459  47  HOH HOH B . 
G 4 HOH 60  460  173 HOH HOH B . 
G 4 HOH 61  461  380 HOH HOH B . 
G 4 HOH 62  462  156 HOH HOH B . 
G 4 HOH 63  463  18  HOH HOH B . 
G 4 HOH 64  464  118 HOH HOH B . 
G 4 HOH 65  465  75  HOH HOH B . 
G 4 HOH 66  466  166 HOH HOH B . 
G 4 HOH 67  467  547 HOH HOH B . 
G 4 HOH 68  468  142 HOH HOH B . 
G 4 HOH 69  469  481 HOH HOH B . 
G 4 HOH 70  470  406 HOH HOH B . 
G 4 HOH 71  471  310 HOH HOH B . 
G 4 HOH 72  472  215 HOH HOH B . 
G 4 HOH 73  473  318 HOH HOH B . 
G 4 HOH 74  474  353 HOH HOH B . 
G 4 HOH 75  475  70  HOH HOH B . 
G 4 HOH 76  476  278 HOH HOH B . 
G 4 HOH 77  477  109 HOH HOH B . 
G 4 HOH 78  478  521 HOH HOH B . 
G 4 HOH 79  479  35  HOH HOH B . 
G 4 HOH 80  480  312 HOH HOH B . 
G 4 HOH 81  481  113 HOH HOH B . 
G 4 HOH 82  482  84  HOH HOH B . 
G 4 HOH 83  483  524 HOH HOH B . 
G 4 HOH 84  484  208 HOH HOH B . 
G 4 HOH 85  485  174 HOH HOH B . 
G 4 HOH 86  486  134 HOH HOH B . 
G 4 HOH 87  487  152 HOH HOH B . 
G 4 HOH 88  488  94  HOH HOH B . 
G 4 HOH 89  489  130 HOH HOH B . 
G 4 HOH 90  490  205 HOH HOH B . 
G 4 HOH 91  491  66  HOH HOH B . 
G 4 HOH 92  492  187 HOH HOH B . 
G 4 HOH 93  493  126 HOH HOH B . 
G 4 HOH 94  494  102 HOH HOH B . 
G 4 HOH 95  495  57  HOH HOH B . 
G 4 HOH 96  496  111 HOH HOH B . 
G 4 HOH 97  497  73  HOH HOH B . 
G 4 HOH 98  498  76  HOH HOH B . 
G 4 HOH 99  499  29  HOH HOH B . 
G 4 HOH 100 500  149 HOH HOH B . 
G 4 HOH 101 501  117 HOH HOH B . 
G 4 HOH 102 502  169 HOH HOH B . 
G 4 HOH 103 503  98  HOH HOH B . 
G 4 HOH 104 504  503 HOH HOH B . 
G 4 HOH 105 505  535 HOH HOH B . 
G 4 HOH 106 506  121 HOH HOH B . 
G 4 HOH 107 507  25  HOH HOH B . 
G 4 HOH 108 508  287 HOH HOH B . 
G 4 HOH 109 509  459 HOH HOH B . 
G 4 HOH 110 510  44  HOH HOH B . 
G 4 HOH 111 511  364 HOH HOH B . 
G 4 HOH 112 512  11  HOH HOH B . 
G 4 HOH 113 513  236 HOH HOH B . 
G 4 HOH 114 514  88  HOH HOH B . 
G 4 HOH 115 515  269 HOH HOH B . 
G 4 HOH 116 516  167 HOH HOH B . 
G 4 HOH 117 517  460 HOH HOH B . 
G 4 HOH 118 518  321 HOH HOH B . 
G 4 HOH 119 519  192 HOH HOH B . 
G 4 HOH 120 520  139 HOH HOH B . 
G 4 HOH 121 521  506 HOH HOH B . 
G 4 HOH 122 522  164 HOH HOH B . 
G 4 HOH 123 523  93  HOH HOH B . 
G 4 HOH 124 524  342 HOH HOH B . 
G 4 HOH 125 525  223 HOH HOH B . 
G 4 HOH 126 526  151 HOH HOH B . 
G 4 HOH 127 527  46  HOH HOH B . 
G 4 HOH 128 528  334 HOH HOH B . 
G 4 HOH 129 529  356 HOH HOH B . 
G 4 HOH 130 530  135 HOH HOH B . 
G 4 HOH 131 531  32  HOH HOH B . 
G 4 HOH 132 532  74  HOH HOH B . 
G 4 HOH 133 533  188 HOH HOH B . 
G 4 HOH 134 534  36  HOH HOH B . 
G 4 HOH 135 535  237 HOH HOH B . 
G 4 HOH 136 536  355 HOH HOH B . 
G 4 HOH 137 537  564 HOH HOH B . 
G 4 HOH 138 538  65  HOH HOH B . 
G 4 HOH 139 539  319 HOH HOH B . 
G 4 HOH 140 540  388 HOH HOH B . 
G 4 HOH 141 541  69  HOH HOH B . 
G 4 HOH 142 542  548 HOH HOH B . 
G 4 HOH 143 543  288 HOH HOH B . 
G 4 HOH 144 544  128 HOH HOH B . 
G 4 HOH 145 545  366 HOH HOH B . 
G 4 HOH 146 546  562 HOH HOH B . 
G 4 HOH 147 547  518 HOH HOH B . 
G 4 HOH 148 548  384 HOH HOH B . 
G 4 HOH 149 549  12  HOH HOH B . 
G 4 HOH 150 550  529 HOH HOH B . 
G 4 HOH 151 551  201 HOH HOH B . 
G 4 HOH 152 552  412 HOH HOH B . 
G 4 HOH 153 553  181 HOH HOH B . 
G 4 HOH 154 554  179 HOH HOH B . 
G 4 HOH 155 555  325 HOH HOH B . 
G 4 HOH 156 556  26  HOH HOH B . 
G 4 HOH 157 557  320 HOH HOH B . 
G 4 HOH 158 558  294 HOH HOH B . 
G 4 HOH 159 559  235 HOH HOH B . 
G 4 HOH 160 560  196 HOH HOH B . 
G 4 HOH 161 561  307 HOH HOH B . 
G 4 HOH 162 562  234 HOH HOH B . 
G 4 HOH 163 563  120 HOH HOH B . 
G 4 HOH 164 564  410 HOH HOH B . 
G 4 HOH 165 565  212 HOH HOH B . 
G 4 HOH 166 566  574 HOH HOH B . 
G 4 HOH 167 567  411 HOH HOH B . 
G 4 HOH 168 568  532 HOH HOH B . 
G 4 HOH 169 569  527 HOH HOH B . 
G 4 HOH 170 570  531 HOH HOH B . 
G 4 HOH 171 571  391 HOH HOH B . 
G 4 HOH 172 572  272 HOH HOH B . 
G 4 HOH 173 573  354 HOH HOH B . 
G 4 HOH 174 574  526 HOH HOH B . 
G 4 HOH 175 575  49  HOH HOH B . 
G 4 HOH 176 576  293 HOH HOH B . 
G 4 HOH 177 577  536 HOH HOH B . 
G 4 HOH 178 578  336 HOH HOH B . 
G 4 HOH 179 579  131 HOH HOH B . 
G 4 HOH 180 580  505 HOH HOH B . 
G 4 HOH 181 581  448 HOH HOH B . 
G 4 HOH 182 582  479 HOH HOH B . 
G 4 HOH 183 583  265 HOH HOH B . 
G 4 HOH 184 584  296 HOH HOH B . 
G 4 HOH 185 585  248 HOH HOH B . 
G 4 HOH 186 586  555 HOH HOH B . 
G 4 HOH 187 587  504 HOH HOH B . 
G 4 HOH 188 588  345 HOH HOH B . 
G 4 HOH 189 589  247 HOH HOH B . 
G 4 HOH 190 590  328 HOH HOH B . 
G 4 HOH 191 591  68  HOH HOH B . 
G 4 HOH 192 592  530 HOH HOH B . 
G 4 HOH 193 593  194 HOH HOH B . 
G 4 HOH 194 594  546 HOH HOH B . 
G 4 HOH 195 595  276 HOH HOH B . 
G 4 HOH 196 596  369 HOH HOH B . 
G 4 HOH 197 597  575 HOH HOH B . 
G 4 HOH 198 598  580 HOH HOH B . 
H 4 HOH 1   2601 423 HOH HOH C . 
H 4 HOH 2   2602 176 HOH HOH C . 
H 4 HOH 3   2603 463 HOH HOH C . 
H 4 HOH 4   2604 475 HOH HOH C . 
H 4 HOH 5   2605 78  HOH HOH C . 
H 4 HOH 6   2606 447 HOH HOH C . 
H 4 HOH 7   2607 514 HOH HOH C . 
H 4 HOH 8   2608 492 HOH HOH C . 
H 4 HOH 9   2609 232 HOH HOH C . 
H 4 HOH 10  2610 438 HOH HOH C . 
H 4 HOH 11  2611 483 HOH HOH C . 
H 4 HOH 12  2612 79  HOH HOH C . 
H 4 HOH 13  2613 507 HOH HOH C . 
H 4 HOH 14  2614 87  HOH HOH C . 
H 4 HOH 15  2615 512 HOH HOH C . 
H 4 HOH 16  2616 486 HOH HOH C . 
H 4 HOH 17  2617 470 HOH HOH C . 
H 4 HOH 18  2618 24  HOH HOH C . 
H 4 HOH 19  2619 262 HOH HOH C . 
H 4 HOH 20  2620 299 HOH HOH C . 
H 4 HOH 21  2621 424 HOH HOH C . 
H 4 HOH 22  2622 7   HOH HOH C . 
H 4 HOH 23  2623 9   HOH HOH C . 
H 4 HOH 24  2624 38  HOH HOH C . 
H 4 HOH 25  2625 487 HOH HOH C . 
H 4 HOH 26  2626 159 HOH HOH C . 
H 4 HOH 27  2627 163 HOH HOH C . 
H 4 HOH 28  2628 493 HOH HOH C . 
H 4 HOH 29  2629 550 HOH HOH C . 
H 4 HOH 30  2630 465 HOH HOH C . 
H 4 HOH 31  2631 67  HOH HOH C . 
H 4 HOH 32  2632 484 HOH HOH C . 
H 4 HOH 33  2633 431 HOH HOH C . 
H 4 HOH 34  2634 468 HOH HOH C . 
H 4 HOH 35  2635 471 HOH HOH C . 
H 4 HOH 36  2636 485 HOH HOH C . 
H 4 HOH 37  2637 19  HOH HOH C . 
H 4 HOH 38  2638 515 HOH HOH C . 
H 4 HOH 39  2639 432 HOH HOH C . 
H 4 HOH 40  2640 233 HOH HOH C . 
H 4 HOH 41  2641 10  HOH HOH C . 
H 4 HOH 42  2642 60  HOH HOH C . 
H 4 HOH 43  2643 132 HOH HOH C . 
H 4 HOH 44  2644 77  HOH HOH C . 
H 4 HOH 45  2645 440 HOH HOH C . 
H 4 HOH 46  2646 150 HOH HOH C . 
H 4 HOH 47  2647 466 HOH HOH C . 
H 4 HOH 48  2648 513 HOH HOH C . 
H 4 HOH 49  2649 368 HOH HOH C . 
H 4 HOH 50  2650 425 HOH HOH C . 
H 4 HOH 51  2651 53  HOH HOH C . 
H 4 HOH 52  2652 107 HOH HOH C . 
H 4 HOH 53  2653 488 HOH HOH C . 
H 4 HOH 54  2654 473 HOH HOH C . 
H 4 HOH 55  2655 498 HOH HOH C . 
H 4 HOH 56  2656 37  HOH HOH C . 
H 4 HOH 57  2657 476 HOH HOH C . 
H 4 HOH 58  2658 297 HOH HOH C . 
H 4 HOH 59  2659 508 HOH HOH C . 
H 4 HOH 60  2660 489 HOH HOH C . 
H 4 HOH 61  2661 573 HOH HOH C . 
H 4 HOH 62  2662 510 HOH HOH C . 
H 4 HOH 63  2663 469 HOH HOH C . 
H 4 HOH 64  2664 61  HOH HOH C . 
H 4 HOH 65  2665 439 HOH HOH C . 
H 4 HOH 66  2666 494 HOH HOH C . 
H 4 HOH 67  2667 511 HOH HOH C . 
H 4 HOH 68  2668 322 HOH HOH C . 
H 4 HOH 69  2669 474 HOH HOH C . 
H 4 HOH 70  2670 462 HOH HOH C . 
H 4 HOH 71  2671 458 HOH HOH C . 
H 4 HOH 72  2672 105 HOH HOH C . 
H 4 HOH 73  2673 138 HOH HOH C . 
H 4 HOH 74  2674 408 HOH HOH C . 
H 4 HOH 75  2675 472 HOH HOH C . 
H 4 HOH 76  2676 534 HOH HOH C . 
H 4 HOH 77  2677 427 HOH HOH C . 
H 4 HOH 78  2678 154 HOH HOH C . 
H 4 HOH 79  2679 528 HOH HOH C . 
H 4 HOH 80  2680 482 HOH HOH C . 
H 4 HOH 81  2681 376 HOH HOH C . 
H 4 HOH 82  2682 557 HOH HOH C . 
H 4 HOH 83  2683 477 HOH HOH C . 
H 4 HOH 84  2684 568 HOH HOH C . 
H 4 HOH 85  2685 576 HOH HOH C . 
H 4 HOH 86  2686 556 HOH HOH C . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A HIS 0    ? CG    ? A HIS 20  CG    
2  1 Y 1 A HIS 0    ? ND1   ? A HIS 20  ND1   
3  1 Y 1 A HIS 0    ? CD2   ? A HIS 20  CD2   
4  1 Y 1 A HIS 0    ? CE1   ? A HIS 20  CE1   
5  1 Y 1 A HIS 0    ? NE2   ? A HIS 20  NE2   
6  1 Y 1 A ARG 233  ? NE    ? A ARG 253 NE    
7  1 Y 1 A ARG 233  ? CZ    ? A ARG 253 CZ    
8  1 Y 1 A ARG 233  ? NH1   ? A ARG 253 NH1   
9  1 Y 1 A ARG 233  ? NH2   ? A ARG 253 NH2   
10 1 Y 1 B LYS 21   ? CG    ? B LYS 41  CG    
11 1 Y 1 B LYS 21   ? CD    ? B LYS 41  CD    
12 1 Y 1 B LYS 21   ? CE    ? B LYS 41  CE    
13 1 Y 1 B LYS 21   ? NZ    ? B LYS 41  NZ    
14 1 Y 1 B ASP 211  ? CA    ? B ASP 231 CA    
15 1 Y 1 B ASP 211  ? C     ? B ASP 231 C     
16 1 Y 1 B ASP 211  ? O     ? B ASP 231 O     
17 1 Y 1 B ASP 211  ? CB    ? B ASP 231 CB    
18 1 Y 1 B ASP 211  ? CG    ? B ASP 231 CG    
19 1 Y 1 B ASP 211  ? OD1   ? B ASP 231 OD1   
20 1 Y 1 B ASP 211  ? OD2   ? B ASP 231 OD2   
21 1 Y 1 B LYS 212  ? CB    ? B LYS 232 CB    
22 1 Y 1 B LYS 212  ? CG    ? B LYS 232 CG    
23 1 Y 1 B LYS 212  ? CD    ? B LYS 232 CD    
24 1 Y 1 B LYS 212  ? CE    ? B LYS 232 CE    
25 1 Y 1 B LYS 212  ? NZ    ? B LYS 232 NZ    
26 1 Y 1 C C   2521 ? N1    ? C C   9   N1    
27 1 Y 1 C C   2521 ? C2    ? C C   9   C2    
28 1 Y 1 C C   2521 ? O2    ? C C   9   O2    
29 1 Y 1 C C   2521 ? N3    ? C C   9   N3    
30 1 Y 1 C C   2521 ? C4    ? C C   9   C4    
31 1 Y 1 C C   2521 ? N4    ? C C   9   N4    
32 1 Y 1 C C   2521 ? C5    ? C C   9   C5    
33 1 Y 1 C C   2521 ? C6    ? C C   9   C6    
34 1 Y 1 C U   2522 ? "C5'" ? C U   10  "C5'" 
35 1 Y 1 C U   2522 ? "C4'" ? C U   10  "C4'" 
36 1 Y 1 C U   2522 ? "O4'" ? C U   10  "O4'" 
37 1 Y 1 C U   2522 ? "C3'" ? C U   10  "C3'" 
38 1 Y 1 C U   2522 ? "O3'" ? C U   10  "O3'" 
39 1 Y 1 C U   2522 ? "C2'" ? C U   10  "C2'" 
40 1 Y 1 C U   2522 ? "O2'" ? C U   10  "O2'" 
41 1 Y 1 C U   2522 ? "C1'" ? C U   10  "C1'" 
42 1 Y 1 C U   2522 ? N1    ? C U   10  N1    
43 1 Y 1 C U   2522 ? C2    ? C U   10  C2    
44 1 Y 1 C U   2522 ? O2    ? C U   10  O2    
45 1 Y 1 C U   2522 ? N3    ? C U   10  N3    
46 1 Y 1 C U   2522 ? C4    ? C U   10  C4    
47 1 Y 1 C U   2522 ? O4    ? C U   10  O4    
48 1 Y 1 C U   2522 ? C5    ? C U   10  C5    
49 1 Y 1 C U   2522 ? C6    ? C U   10  C6    
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.11_2563 1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XSCALE ? ? ? .         2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .         3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .         4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9H1K 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     113.040 
_cell.length_a_esd                 ? 
_cell.length_b                     117.430 
_cell.length_b_esd                 ? 
_cell.length_c                     58.250 
_cell.length_c_esd                 ? 
_cell.volume                       773227.229 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9H1K 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                18 
_symmetry.space_group_name_Hall            'P 2 2ab' 
_symmetry.space_group_name_H-M             'P 21 21 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9H1K 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.43 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          49.38 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          MICROBATCH 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              4.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    'Na-Citrate 0.1M, pH5.5, PEG6000 10%, LiCl 1M' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            292 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2024-09-06 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.9786 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SOLEIL BEAMLINE PROXIMA 1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.9786 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   'PROXIMA 1' 
_diffrn_source.pdbx_synchrotron_site       SOLEIL 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9H1K 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.89 
_reflns.d_resolution_low                               58.715 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     62387 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           100 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                13.6 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          16.0 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
loop_
_reflns_shell.d_res_high 
_reflns_shell.d_res_low 
_reflns_shell.meanI_over_sigI_all 
_reflns_shell.meanI_over_sigI_obs 
_reflns_shell.number_measured_all 
_reflns_shell.number_measured_obs 
_reflns_shell.number_possible 
_reflns_shell.number_unique_all 
_reflns_shell.number_unique_obs 
_reflns_shell.percent_possible_obs 
_reflns_shell.Rmerge_F_all 
_reflns_shell.Rmerge_F_obs 
_reflns_shell.meanI_over_sigI_gt 
_reflns_shell.meanI_over_uI_all 
_reflns_shell.meanI_over_uI_gt 
_reflns_shell.number_measured_gt 
_reflns_shell.number_unique_gt 
_reflns_shell.percent_possible_gt 
_reflns_shell.Rmerge_F_gt 
_reflns_shell.Rmerge_I_gt 
_reflns_shell.pdbx_redundancy 
_reflns_shell.pdbx_chi_squared 
_reflns_shell.pdbx_netI_over_sigmaI_all 
_reflns_shell.pdbx_netI_over_sigmaI_obs 
_reflns_shell.pdbx_Rrim_I_all 
_reflns_shell.pdbx_Rpim_I_all 
_reflns_shell.pdbx_rejects 
_reflns_shell.pdbx_ordinal 
_reflns_shell.pdbx_diffrn_id 
_reflns_shell.pdbx_CC_half 
_reflns_shell.pdbx_CC_star 
_reflns_shell.pdbx_R_split 
_reflns_shell.percent_possible_all 
_reflns_shell.Rmerge_I_all 
_reflns_shell.Rmerge_I_obs 
_reflns_shell.pdbx_Rsym_value 
_reflns_shell.pdbx_percent_possible_ellipsoidal 
_reflns_shell.pdbx_percent_possible_spherical 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous 
_reflns_shell.pdbx_percent_possible_spherical_anomalous 
_reflns_shell.pdbx_redundancy_anomalous 
_reflns_shell.pdbx_CC_half_anomalous 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous 
_reflns_shell.pdbx_percent_possible_anomalous 
5.143 58.715 ? ? ? ? ? ? 3361 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 1 1 1.000 ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
1.895 1.928  ? ? ? ? ? ? 3095 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 2 1 0.391 ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               45.3879928322 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9H1K 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.89499696041 
_refine.ls_d_res_low                             41.3523919557 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     62377 
_refine.ls_number_reflns_R_free                  3053 
_refine.ls_number_reflns_R_work                  59324 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.9791633275 
_refine.ls_percent_reflns_R_free                 4.89443224265 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.205115277933 
_refine.ls_R_factor_R_free                       0.232565884209 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.203697642843 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34348413539 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.11 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 23.3219437512 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.244220587834 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.89499696041 
_refine_hist.d_res_low                        41.3523919557 
_refine_hist.number_atoms_solvent             483 
_refine_hist.number_atoms_total               5209 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3938 
_refine_hist.pdbx_number_atoms_nucleic_acid   736 
_refine_hist.pdbx_number_atoms_ligand         52 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0111342225483 ? 4868 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.52909216303   ? 6758 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.123208222997  ? 801  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.023004846995  ? 763  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 21.9791286283   ? 1970 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.895  1.9246 . . 130 2664 99.7857142857 . . . . 0.335523787591 . . . . . . . . . . . 0.340841055755 
'X-RAY DIFFRACTION' 1.9246 1.9562 . . 145 2664 100.0         . . . . 0.301137713397 . . . . . . . . . . . 0.319411660078 
'X-RAY DIFFRACTION' 1.9562 1.9899 . . 126 2668 100.0         . . . . 0.289560744191 . . . . . . . . . . . 0.393252673668 
'X-RAY DIFFRACTION' 1.9899 2.0261 . . 140 2644 100.0         . . . . 0.266773830476 . . . . . . . . . . . 0.293469479605 
'X-RAY DIFFRACTION' 2.0261 2.065  . . 135 2663 100.0         . . . . 0.261149705194 . . . . . . . . . . . 0.294873701401 
'X-RAY DIFFRACTION' 2.065  2.1072 . . 145 2656 100.0         . . . . 0.251765285286 . . . . . . . . . . . 0.269598741284 
'X-RAY DIFFRACTION' 2.1072 2.153  . . 145 2669 100.0         . . . . 0.234766632675 . . . . . . . . . . . 0.292844998131 
'X-RAY DIFFRACTION' 2.153  2.2031 . . 133 2643 100.0         . . . . 0.229310417517 . . . . . . . . . . . 0.243359825668 
'X-RAY DIFFRACTION' 2.2031 2.2582 . . 139 2694 99.9647141849 . . . . 0.226778883983 . . . . . . . . . . . 0.278536087956 
'X-RAY DIFFRACTION' 2.2582 2.3192 . . 128 2666 100.0         . . . . 0.213936274354 . . . . . . . . . . . 0.254380556315 
'X-RAY DIFFRACTION' 2.3192 2.3875 . . 137 2678 100.0         . . . . 0.207849498743 . . . . . . . . . . . 0.24577736792  
'X-RAY DIFFRACTION' 2.3875 2.4645 . . 151 2675 100.0         . . . . 0.204231172964 . . . . . . . . . . . 0.236336718211 
'X-RAY DIFFRACTION' 2.4645 2.5526 . . 153 2672 100.0         . . . . 0.199647755753 . . . . . . . . . . . 0.255494123557 
'X-RAY DIFFRACTION' 2.5526 2.6548 . . 116 2704 100.0         . . . . 0.20222166426  . . . . . . . . . . . 0.217502531935 
'X-RAY DIFFRACTION' 2.6548 2.7756 . . 134 2716 100.0         . . . . 0.219461287519 . . . . . . . . . . . 0.271067784969 
'X-RAY DIFFRACTION' 2.7756 2.9219 . . 145 2668 99.9644633973 . . . . 0.208333502902 . . . . . . . . . . . 0.239088398109 
'X-RAY DIFFRACTION' 2.9219 3.1049 . . 131 2723 100.0         . . . . 0.199138055026 . . . . . . . . . . . 0.27159302134  
'X-RAY DIFFRACTION' 3.1049 3.3445 . . 138 2705 100.0         . . . . 0.200537551865 . . . . . . . . . . . 0.21424195021  
'X-RAY DIFFRACTION' 3.3445 3.6809 . . 168 2704 99.9651931779 . . . . 0.178396058668 . . . . . . . . . . . 0.205430367251 
'X-RAY DIFFRACTION' 3.6809 4.2131 . . 142 2740 100.0         . . . . 0.17405163849  . . . . . . . . . . . 0.188452577324 
'X-RAY DIFFRACTION' 4.2131 5.3063 . . 120 2804 100.0         . . . . 0.170329127444 . . . . . . . . . . . 0.209732234696 
'X-RAY DIFFRACTION' 5.3063 41.35  . . 152 2904 99.8692810458 . . . . 0.209568390794 . . . . . . . . . . . 0.213713834883 
# 
_struct.entry_id                     9H1K 
_struct.title                        
'RlmR 23S rRNA methyltransferase from Thermus thermophilus in complex with rRNA and S-adenosyl-L-homocysteine (SAH)' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9H1K 
_struct_keywords.text            '23S rRNA methyltransferase, SPOUT Family, complex., TRANSFERASE' 
_struct_keywords.pdbx_keywords   TRANSFERASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 3 ? 
E N N 3 ? 
F N N 4 ? 
G N N 4 ? 
H N N 4 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP Q72GY4_THET2 Q72GY4   ? 1 
;MRIESPQNPRVKALAALKERKERERTGRFLVEGRREVERALEAGLSLETLLLGPKARPEDRALAGGAEVLELSERALARV
SARENPAQVLGVFRLPRRSLAGVTLGAAPLVLVLLGLEKPGNLGAILRAADGAGADLVLVAEGVDLFSPQVIRNSTGAVF
ALPVYPVAEEEAARFLEEQNLPLVAATPEGERLYWEGDYRGGVAFLLGAEDKGLPEAWKRRAQVRVRIPMRGRADSLNVA
VTAALLLYEALRQRSGGAPL
;
1       
2 GB  AE017221.1   46197919 ? 2 GUCGCAUCCUGGGGCUGAAGAAGGUCCCAAGGGUUGGGCUGUUCGCCCAUUAAAGCGGC 1536991 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9H1K A 21 ? 280 ? Q72GY4   1       ? 260     ? 1    260  
2 1 9H1K B 21 ? 280 ? Q72GY4   1       ? 260     ? 1    260  
3 2 9H1K C 1  ? 59  ? 46197919 1536991 ? 1537049 ? 2513 2571 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9H1K MET A 1  ? UNP Q72GY4 ? ? 'initiating methionine' -19 1  
1 9H1K GLY A 2  ? UNP Q72GY4 ? ? 'expression tag'        -18 2  
1 9H1K SER A 3  ? UNP Q72GY4 ? ? 'expression tag'        -17 3  
1 9H1K SER A 4  ? UNP Q72GY4 ? ? 'expression tag'        -16 4  
1 9H1K HIS A 5  ? UNP Q72GY4 ? ? 'expression tag'        -15 5  
1 9H1K HIS A 6  ? UNP Q72GY4 ? ? 'expression tag'        -14 6  
1 9H1K HIS A 7  ? UNP Q72GY4 ? ? 'expression tag'        -13 7  
1 9H1K HIS A 8  ? UNP Q72GY4 ? ? 'expression tag'        -12 8  
1 9H1K HIS A 9  ? UNP Q72GY4 ? ? 'expression tag'        -11 9  
1 9H1K HIS A 10 ? UNP Q72GY4 ? ? 'expression tag'        -10 10 
1 9H1K SER A 11 ? UNP Q72GY4 ? ? 'expression tag'        -9  11 
1 9H1K SER A 12 ? UNP Q72GY4 ? ? 'expression tag'        -8  12 
1 9H1K GLY A 13 ? UNP Q72GY4 ? ? 'expression tag'        -7  13 
1 9H1K LEU A 14 ? UNP Q72GY4 ? ? 'expression tag'        -6  14 
1 9H1K VAL A 15 ? UNP Q72GY4 ? ? 'expression tag'        -5  15 
1 9H1K PRO A 16 ? UNP Q72GY4 ? ? 'expression tag'        -4  16 
1 9H1K ARG A 17 ? UNP Q72GY4 ? ? 'expression tag'        -3  17 
1 9H1K GLY A 18 ? UNP Q72GY4 ? ? 'expression tag'        -2  18 
1 9H1K SER A 19 ? UNP Q72GY4 ? ? 'expression tag'        -1  19 
1 9H1K HIS A 20 ? UNP Q72GY4 ? ? 'expression tag'        0   20 
2 9H1K MET B 1  ? UNP Q72GY4 ? ? 'initiating methionine' -19 21 
2 9H1K GLY B 2  ? UNP Q72GY4 ? ? 'expression tag'        -18 22 
2 9H1K SER B 3  ? UNP Q72GY4 ? ? 'expression tag'        -17 23 
2 9H1K SER B 4  ? UNP Q72GY4 ? ? 'expression tag'        -16 24 
2 9H1K HIS B 5  ? UNP Q72GY4 ? ? 'expression tag'        -15 25 
2 9H1K HIS B 6  ? UNP Q72GY4 ? ? 'expression tag'        -14 26 
2 9H1K HIS B 7  ? UNP Q72GY4 ? ? 'expression tag'        -13 27 
2 9H1K HIS B 8  ? UNP Q72GY4 ? ? 'expression tag'        -12 28 
2 9H1K HIS B 9  ? UNP Q72GY4 ? ? 'expression tag'        -11 29 
2 9H1K HIS B 10 ? UNP Q72GY4 ? ? 'expression tag'        -10 30 
2 9H1K SER B 11 ? UNP Q72GY4 ? ? 'expression tag'        -9  31 
2 9H1K SER B 12 ? UNP Q72GY4 ? ? 'expression tag'        -8  32 
2 9H1K GLY B 13 ? UNP Q72GY4 ? ? 'expression tag'        -7  33 
2 9H1K LEU B 14 ? UNP Q72GY4 ? ? 'expression tag'        -6  34 
2 9H1K VAL B 15 ? UNP Q72GY4 ? ? 'expression tag'        -5  35 
2 9H1K PRO B 16 ? UNP Q72GY4 ? ? 'expression tag'        -4  36 
2 9H1K ARG B 17 ? UNP Q72GY4 ? ? 'expression tag'        -3  37 
2 9H1K GLY B 18 ? UNP Q72GY4 ? ? 'expression tag'        -2  38 
2 9H1K SER B 19 ? UNP Q72GY4 ? ? 'expression tag'        -1  39 
2 9H1K HIS B 20 ? UNP Q72GY4 ? ? 'expression tag'        0   40 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   trimeric 
_pdbx_struct_assembly.oligomeric_count     3 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 6240  ? 
1 MORE         -25   ? 
1 'SSA (A^2)'  26390 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H 
# 
loop_
_pdbx_struct_assembly_auth_evidence.id 
_pdbx_struct_assembly_auth_evidence.assembly_id 
_pdbx_struct_assembly_auth_evidence.experimental_support 
_pdbx_struct_assembly_auth_evidence.details 
1 1 'native gel electrophoresis' ? 
2 1 'gel filtration'             ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASN A 28  ? ALA A 36  ? ASN A 8   ALA A 16  1 ? 9  
HELX_P HELX_P2  AA2 GLU A 39  ? GLY A 47  ? GLU A 19  GLY A 27  1 ? 9  
HELX_P HELX_P3  AA3 GLY A 53  ? ALA A 63  ? GLY A 33  ALA A 43  1 ? 11 
HELX_P HELX_P4  AA4 ARG A 77  ? ALA A 82  ? ARG A 57  ALA A 62  1 ? 6  
HELX_P HELX_P5  AA5 SER A 93  ? SER A 101 ? SER A 73  SER A 81  1 ? 9  
HELX_P HELX_P6  AA6 SER A 119 ? VAL A 123 ? SER A 99  VAL A 103 5 ? 5  
HELX_P HELX_P7  AA7 LYS A 139 ? GLY A 154 ? LYS A 119 GLY A 134 1 ? 16 
HELX_P HELX_P8  AA8 SER A 168 ? SER A 175 ? SER A 148 SER A 155 1 ? 8  
HELX_P HELX_P9  AA9 GLY A 177 ? ALA A 181 ? GLY A 157 ALA A 161 5 ? 5  
HELX_P HELX_P10 AB1 ALA A 188 ? ASN A 200 ? ALA A 168 ASN A 180 1 ? 13 
HELX_P HELX_P11 AB2 TRP A 215 ? GLY A 217 ? TRP A 195 GLY A 197 5 ? 3  
HELX_P HELX_P12 AB3 PRO A 235 ? ALA A 242 ? PRO A 215 ALA A 222 1 ? 8  
HELX_P HELX_P13 AB4 ASN A 258 ? SER A 275 ? ASN A 238 SER A 255 1 ? 18 
HELX_P HELX_P14 AB5 ASN B 28  ? ALA B 36  ? ASN B 8   ALA B 16  1 ? 9  
HELX_P HELX_P15 AB6 GLU B 39  ? GLY B 47  ? GLU B 19  GLY B 27  1 ? 9  
HELX_P HELX_P16 AB7 GLY B 53  ? ALA B 63  ? GLY B 33  ALA B 43  1 ? 11 
HELX_P HELX_P17 AB8 ARG B 77  ? ALA B 82  ? ARG B 57  ALA B 62  1 ? 6  
HELX_P HELX_P18 AB9 SER B 93  ? SER B 101 ? SER B 73  SER B 81  1 ? 9  
HELX_P HELX_P19 AC1 SER B 119 ? VAL B 123 ? SER B 99  VAL B 103 5 ? 5  
HELX_P HELX_P20 AC2 LYS B 139 ? GLY B 154 ? LYS B 119 GLY B 134 1 ? 16 
HELX_P HELX_P21 AC3 SER B 168 ? SER B 175 ? SER B 148 SER B 155 1 ? 8  
HELX_P HELX_P22 AC4 GLY B 177 ? ALA B 181 ? GLY B 157 ALA B 161 5 ? 5  
HELX_P HELX_P23 AC5 ALA B 188 ? GLN B 199 ? ALA B 168 GLN B 179 1 ? 12 
HELX_P HELX_P24 AC6 TRP B 215 ? GLY B 217 ? TRP B 195 GLY B 197 5 ? 3  
HELX_P HELX_P25 AC7 PRO B 235 ? ALA B 242 ? PRO B 215 ALA B 222 1 ? 8  
HELX_P HELX_P26 AC8 ASN B 258 ? SER B 275 ? ASN B 238 SER B 255 1 ? 18 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
hydrog1  hydrog ? ? C G 1  N1 ? ? ? 1_555 C C 59 N3 ? ? C G 2513 C C 2571 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog2  hydrog ? ? C G 1  N2 ? ? ? 1_555 C C 59 O2 ? ? C G 2513 C C 2571 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog3  hydrog ? ? C G 1  O6 ? ? ? 1_555 C C 59 N4 ? ? C G 2513 C C 2571 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog4  hydrog ? ? C U 2  N3 ? ? ? 1_555 C G 58 O6 ? ? C U 2514 C G 2570 1_555 ? ? ? ? ? ? TYPE_28_PAIR ? ? ? 
hydrog5  hydrog ? ? C U 2  O2 ? ? ? 1_555 C G 58 N1 ? ? C U 2514 C G 2570 1_555 ? ? ? ? ? ? TYPE_28_PAIR ? ? ? 
hydrog6  hydrog ? ? C C 3  N3 ? ? ? 1_555 C G 57 N1 ? ? C C 2515 C G 2569 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog7  hydrog ? ? C C 3  N4 ? ? ? 1_555 C G 57 O6 ? ? C C 2515 C G 2569 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog8  hydrog ? ? C C 3  O2 ? ? ? 1_555 C G 57 N2 ? ? C C 2515 C G 2569 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog9  hydrog ? ? C G 4  N1 ? ? ? 1_555 C C 56 N3 ? ? C G 2516 C C 2568 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog10 hydrog ? ? C G 4  N2 ? ? ? 1_555 C C 56 O2 ? ? C G 2516 C C 2568 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog11 hydrog ? ? C G 4  O6 ? ? ? 1_555 C C 56 N4 ? ? C G 2516 C C 2568 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog12 hydrog ? ? C C 5  N3 ? ? ? 1_555 C G 55 N1 ? ? C C 2517 C G 2567 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog13 hydrog ? ? C C 5  N4 ? ? ? 1_555 C G 55 O6 ? ? C C 2517 C G 2567 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog14 hydrog ? ? C C 5  O2 ? ? ? 1_555 C G 55 N2 ? ? C C 2517 C G 2567 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog15 hydrog ? ? C A 6  N1 ? ? ? 1_555 C U 34 N3 ? ? C A 2518 C U 2546 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog16 hydrog ? ? C A 6  N6 ? ? ? 1_555 C U 34 O4 ? ? C A 2518 C U 2546 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog17 hydrog ? ? C U 7  N3 ? ? ? 1_555 C G 33 O6 ? ? C U 2519 C G 2545 1_555 ? ? ? ? ? ? TYPE_28_PAIR ? ? ? 
hydrog18 hydrog ? ? C U 7  O2 ? ? ? 1_555 C G 33 N1 ? ? C U 2519 C G 2545 1_555 ? ? ? ? ? ? TYPE_28_PAIR ? ? ? 
hydrog19 hydrog ? ? C C 8  N3 ? ? ? 1_555 C G 32 N1 ? ? C C 2520 C G 2544 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog20 hydrog ? ? C C 8  N4 ? ? ? 1_555 C G 32 O6 ? ? C C 2520 C G 2544 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog21 hydrog ? ? C C 8  O2 ? ? ? 1_555 C G 32 N2 ? ? C C 2520 C G 2544 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog22 hydrog ? ? C U 35 N3 ? ? ? 1_555 C A 49 N1 ? ? C U 2547 C A 2561 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog23 hydrog ? ? C U 35 O4 ? ? ? 1_555 C A 49 N6 ? ? C U 2547 C A 2561 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog24 hydrog ? ? C G 36 N1 ? ? ? 1_555 C C 48 N3 ? ? C G 2548 C C 2560 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog25 hydrog ? ? C G 36 N2 ? ? ? 1_555 C C 48 O2 ? ? C G 2548 C C 2560 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog26 hydrog ? ? C G 36 O6 ? ? ? 1_555 C C 48 N4 ? ? C G 2548 C C 2560 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog27 hydrog ? ? C G 37 N1 ? ? ? 1_555 C C 47 N3 ? ? C G 2549 C C 2559 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog28 hydrog ? ? C G 37 N2 ? ? ? 1_555 C C 47 O2 ? ? C G 2549 C C 2559 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog29 hydrog ? ? C G 37 O6 ? ? ? 1_555 C C 47 N4 ? ? C G 2549 C C 2559 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog30 hydrog ? ? C G 38 N1 ? ? ? 1_555 C C 46 N3 ? ? C G 2550 C C 2558 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog31 hydrog ? ? C G 38 N2 ? ? ? 1_555 C C 46 O2 ? ? C G 2550 C C 2558 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog32 hydrog ? ? C G 38 O6 ? ? ? 1_555 C C 46 N4 ? ? C G 2550 C C 2558 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog33 hydrog ? ? C C 39 N3 ? ? ? 1_555 C G 45 N1 ? ? C C 2551 C G 2557 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog34 hydrog ? ? C C 39 N4 ? ? ? 1_555 C G 45 O6 ? ? C C 2551 C G 2557 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
hydrog35 hydrog ? ? C C 39 O2 ? ? ? 1_555 C G 45 N2 ? ? C C 2551 C G 2557 1_555 ? ? ? ? ? ? WATSON-CRICK ? ? ? 
# 
_struct_conn_type.id          hydrog 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 7 ? 
AA3 ? 4 ? 
AA4 ? 7 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA1 2 3 ? parallel      
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? parallel      
AA2 3 4 ? parallel      
AA2 4 5 ? parallel      
AA2 5 6 ? parallel      
AA2 6 7 ? parallel      
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? parallel      
AA4 1 2 ? parallel      
AA4 2 3 ? parallel      
AA4 3 4 ? parallel      
AA4 4 5 ? parallel      
AA4 5 6 ? parallel      
AA4 6 7 ? parallel      
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 MET A 21  ? ILE A 23  ? MET A 1   ILE A 3   
AA1 2 GLU A 88  ? LEU A 92  ? GLU A 68  LEU A 72  
AA1 3 LEU A 67  ? LEU A 72  ? LEU A 47  LEU A 52  
AA1 4 VAL A 109 ? ARG A 114 ? VAL A 89  ARG A 94  
AA1 5 ARG A 48  ? GLU A 52  ? ARG A 28  GLU A 32  
AA2 1 VAL A 184 ? VAL A 187 ? VAL A 164 VAL A 167 
AA2 2 LEU A 157 ? ALA A 161 ? LEU A 137 ALA A 141 
AA2 3 LEU A 130 ? LEU A 135 ? LEU A 110 LEU A 115 
AA2 4 VAL A 223 ? LEU A 227 ? VAL A 203 LEU A 207 
AA2 5 LEU A 203 ? ALA A 206 ? LEU A 183 ALA A 186 
AA2 6 VAL A 244 ? ARG A 247 ? VAL A 224 ARG A 227 
AA2 7 ARG A 212 ? LEU A 213 ? ARG A 192 LEU A 193 
AA3 1 ARG B 48  ? GLU B 52  ? ARG B 28  GLU B 32  
AA3 2 VAL B 109 ? ARG B 114 ? VAL B 89  ARG B 94  
AA3 3 LEU B 67  ? LEU B 72  ? LEU B 47  LEU B 52  
AA3 4 GLU B 88  ? GLU B 91  ? GLU B 68  GLU B 71  
AA4 1 VAL B 184 ? PRO B 186 ? VAL B 164 PRO B 166 
AA4 2 LEU B 157 ? VAL B 160 ? LEU B 137 VAL B 140 
AA4 3 LEU B 130 ? LEU B 134 ? LEU B 110 LEU B 114 
AA4 4 VAL B 223 ? LEU B 227 ? VAL B 203 LEU B 207 
AA4 5 LEU B 203 ? ALA B 206 ? LEU B 183 ALA B 186 
AA4 6 VAL B 244 ? ARG B 247 ? VAL B 224 ARG B 227 
AA4 7 ARG B 212 ? LEU B 213 ? ARG B 192 LEU B 193 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ILE A 23  ? N ILE A 3   O GLU A 91  ? O GLU A 71  
AA1 2 3 O LEU A 90  ? O LEU A 70  N LEU A 70  ? N LEU A 50  
AA1 3 4 N LEU A 71  ? N LEU A 51  O LEU A 110 ? O LEU A 90  
AA1 4 5 O GLY A 111 ? O GLY A 91  N VAL A 51  ? N VAL A 31  
AA2 1 2 O TYR A 185 ? O TYR A 165 N VAL A 158 ? N VAL A 138 
AA2 2 3 O ALA A 161 ? O ALA A 141 N LEU A 134 ? N LEU A 114 
AA2 3 4 N LEU A 135 ? N LEU A 115 O LEU A 227 ? O LEU A 207 
AA2 4 5 O ALA A 224 ? O ALA A 204 N VAL A 204 ? N VAL A 184 
AA2 5 6 N ALA A 205 ? N ALA A 185 O VAL A 244 ? O VAL A 224 
AA2 6 7 O ARG A 247 ? O ARG A 227 N ARG A 212 ? N ARG A 192 
AA3 1 2 N VAL B 51  ? N VAL B 31  O GLY B 111 ? O GLY B 91  
AA3 2 3 O VAL B 112 ? O VAL B 92  N GLU B 68  ? N GLU B 48  
AA3 3 4 N LEU B 70  ? N LEU B 50  O LEU B 90  ? O LEU B 70  
AA4 1 2 O TYR B 185 ? O TYR B 165 N VAL B 158 ? N VAL B 138 
AA4 2 3 O LEU B 159 ? O LEU B 139 N LEU B 134 ? N LEU B 114 
AA4 3 4 N VAL B 133 ? N VAL B 113 O PHE B 225 ? O PHE B 205 
AA4 4 5 O LEU B 226 ? O LEU B 206 N VAL B 204 ? N VAL B 184 
AA4 5 6 N ALA B 205 ? N ALA B 185 O VAL B 246 ? O VAL B 226 
AA4 6 7 O ARG B 247 ? O ARG B 227 N ARG B 212 ? N ARG B 192 
# 
_pdbx_entry_details.entry_id                   9H1K 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_rmsd_angle.id                         1 
_pdbx_validate_rmsd_angle.PDB_model_num              1 
_pdbx_validate_rmsd_angle.auth_atom_id_1             "C1'" 
_pdbx_validate_rmsd_angle.auth_asym_id_1             C 
_pdbx_validate_rmsd_angle.auth_comp_id_1             U 
_pdbx_validate_rmsd_angle.auth_seq_id_1              2555 
_pdbx_validate_rmsd_angle.PDB_ins_code_1             ? 
_pdbx_validate_rmsd_angle.label_alt_id_1             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_2             "O4'" 
_pdbx_validate_rmsd_angle.auth_asym_id_2             C 
_pdbx_validate_rmsd_angle.auth_comp_id_2             U 
_pdbx_validate_rmsd_angle.auth_seq_id_2              2555 
_pdbx_validate_rmsd_angle.PDB_ins_code_2             ? 
_pdbx_validate_rmsd_angle.label_alt_id_2             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_3             "C4'" 
_pdbx_validate_rmsd_angle.auth_asym_id_3             C 
_pdbx_validate_rmsd_angle.auth_comp_id_3             U 
_pdbx_validate_rmsd_angle.auth_seq_id_3              2555 
_pdbx_validate_rmsd_angle.PDB_ins_code_3             ? 
_pdbx_validate_rmsd_angle.label_alt_id_3             ? 
_pdbx_validate_rmsd_angle.angle_value                104.45 
_pdbx_validate_rmsd_angle.angle_target_value         109.70 
_pdbx_validate_rmsd_angle.angle_deviation            -5.25 
_pdbx_validate_rmsd_angle.angle_standard_deviation   0.70 
_pdbx_validate_rmsd_angle.linker_flag                N 
# 
loop_
_pdbx_validate_planes.id 
_pdbx_validate_planes.PDB_model_num 
_pdbx_validate_planes.auth_comp_id 
_pdbx_validate_planes.auth_asym_id 
_pdbx_validate_planes.auth_seq_id 
_pdbx_validate_planes.PDB_ins_code 
_pdbx_validate_planes.label_alt_id 
_pdbx_validate_planes.rmsd 
_pdbx_validate_planes.type 
1 1 ARG A 2   ? ? 0.284 'SIDE CHAIN' 
2 1 ARG A 94  ? ? 0.294 'SIDE CHAIN' 
3 1 ARG A 98  ? ? 0.096 'SIDE CHAIN' 
4 1 ARG A 192 ? ? 0.118 'SIDE CHAIN' 
5 1 ARG B 97  ? ? 0.256 'SIDE CHAIN' 
6 1 ARG B 98  ? ? 0.294 'SIDE CHAIN' 
7 1 ARG B 174 ? ? 0.097 'SIDE CHAIN' 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 599  ? 8.87  . 
2 1 O ? B HOH 598  ? 14.40 . 
3 1 O ? C HOH 2686 ? 5.98  . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET -19  ? A MET 1  
2  1 Y 1 A GLY -18  ? A GLY 2  
3  1 Y 1 A SER -17  ? A SER 3  
4  1 Y 1 A SER -16  ? A SER 4  
5  1 Y 1 A HIS -15  ? A HIS 5  
6  1 Y 1 A HIS -14  ? A HIS 6  
7  1 Y 1 A HIS -13  ? A HIS 7  
8  1 Y 1 A HIS -12  ? A HIS 8  
9  1 Y 1 A HIS -11  ? A HIS 9  
10 1 Y 1 A HIS -10  ? A HIS 10 
11 1 Y 1 A SER -9   ? A SER 11 
12 1 Y 1 A SER -8   ? A SER 12 
13 1 Y 1 A GLY -7   ? A GLY 13 
14 1 Y 1 A LEU -6   ? A LEU 14 
15 1 Y 1 A VAL -5   ? A VAL 15 
16 1 Y 1 A PRO -4   ? A PRO 16 
17 1 Y 1 A ARG -3   ? A ARG 17 
18 1 Y 1 A GLY -2   ? A GLY 18 
19 1 Y 1 A SER -1   ? A SER 19 
20 1 Y 1 B MET -19  ? B MET 1  
21 1 Y 1 B GLY -18  ? B GLY 2  
22 1 Y 1 B SER -17  ? B SER 3  
23 1 Y 1 B SER -16  ? B SER 4  
24 1 Y 1 B HIS -15  ? B HIS 5  
25 1 Y 1 B HIS -14  ? B HIS 6  
26 1 Y 1 B HIS -13  ? B HIS 7  
27 1 Y 1 B HIS -12  ? B HIS 8  
28 1 Y 1 B HIS -11  ? B HIS 9  
29 1 Y 1 B HIS -10  ? B HIS 10 
30 1 Y 1 B SER -9   ? B SER 11 
31 1 Y 1 B SER -8   ? B SER 12 
32 1 Y 1 B GLY -7   ? B GLY 13 
33 1 Y 1 B LEU -6   ? B LEU 14 
34 1 Y 1 B VAL -5   ? B VAL 15 
35 1 Y 1 B PRO -4   ? B PRO 16 
36 1 Y 1 B ARG -3   ? B ARG 17 
37 1 Y 1 B GLY -2   ? B GLY 18 
38 1 Y 1 B SER -1   ? B SER 19 
39 1 Y 1 B HIS 0    ? B HIS 20 
40 1 Y 1 C G   2523 ? C G   11 
41 1 Y 1 C G   2524 ? C G   12 
42 1 Y 1 C G   2525 ? C G   13 
43 1 Y 1 C G   2526 ? C G   14 
44 1 Y 1 C C   2527 ? C C   15 
45 1 Y 1 C U   2528 ? C U   16 
46 1 Y 1 C G   2529 ? C G   17 
47 1 Y 1 C A   2530 ? C A   18 
48 1 Y 1 C A   2531 ? C A   19 
49 1 Y 1 C G   2532 ? C G   20 
50 1 Y 1 C A   2533 ? C A   21 
51 1 Y 1 C A   2534 ? C A   22 
52 1 Y 1 C G   2535 ? C G   23 
53 1 Y 1 C G   2536 ? C G   24 
54 1 Y 1 C U   2537 ? C U   25 
55 1 Y 1 C C   2538 ? C C   26 
56 1 Y 1 C C   2539 ? C C   27 
57 1 Y 1 C C   2540 ? C C   28 
58 1 Y 1 C A   2541 ? C A   29 
59 1 Y 1 C A   2542 ? C A   30 
60 1 Y 1 C A   2564 ? C A   52 
61 1 Y 1 C A   2565 ? C A   53 
62 1 Y 1 C A   2566 ? C A   54 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A   OP3    O N N 1   
A   P      P N N 2   
A   OP1    O N N 3   
A   OP2    O N N 4   
A   "O5'"  O N N 5   
A   "C5'"  C N N 6   
A   "C4'"  C N R 7   
A   "O4'"  O N N 8   
A   "C3'"  C N S 9   
A   "O3'"  O N N 10  
A   "C2'"  C N R 11  
A   "O2'"  O N N 12  
A   "C1'"  C N R 13  
A   N9     N Y N 14  
A   C8     C Y N 15  
A   N7     N Y N 16  
A   C5     C Y N 17  
A   C6     C Y N 18  
A   N6     N N N 19  
A   N1     N Y N 20  
A   C2     C Y N 21  
A   N3     N Y N 22  
A   C4     C Y N 23  
A   HOP3   H N N 24  
A   HOP2   H N N 25  
A   "H5'"  H N N 26  
A   "H5''" H N N 27  
A   "H4'"  H N N 28  
A   "H3'"  H N N 29  
A   "HO3'" H N N 30  
A   "H2'"  H N N 31  
A   "HO2'" H N N 32  
A   "H1'"  H N N 33  
A   H8     H N N 34  
A   H61    H N N 35  
A   H62    H N N 36  
A   H2     H N N 37  
ALA N      N N N 38  
ALA CA     C N S 39  
ALA C      C N N 40  
ALA O      O N N 41  
ALA CB     C N N 42  
ALA OXT    O N N 43  
ALA H      H N N 44  
ALA H2     H N N 45  
ALA HA     H N N 46  
ALA HB1    H N N 47  
ALA HB2    H N N 48  
ALA HB3    H N N 49  
ALA HXT    H N N 50  
ARG N      N N N 51  
ARG CA     C N S 52  
ARG C      C N N 53  
ARG O      O N N 54  
ARG CB     C N N 55  
ARG CG     C N N 56  
ARG CD     C N N 57  
ARG NE     N N N 58  
ARG CZ     C N N 59  
ARG NH1    N N N 60  
ARG NH2    N N N 61  
ARG OXT    O N N 62  
ARG H      H N N 63  
ARG H2     H N N 64  
ARG HA     H N N 65  
ARG HB2    H N N 66  
ARG HB3    H N N 67  
ARG HG2    H N N 68  
ARG HG3    H N N 69  
ARG HD2    H N N 70  
ARG HD3    H N N 71  
ARG HE     H N N 72  
ARG HH11   H N N 73  
ARG HH12   H N N 74  
ARG HH21   H N N 75  
ARG HH22   H N N 76  
ARG HXT    H N N 77  
ASN N      N N N 78  
ASN CA     C N S 79  
ASN C      C N N 80  
ASN O      O N N 81  
ASN CB     C N N 82  
ASN CG     C N N 83  
ASN OD1    O N N 84  
ASN ND2    N N N 85  
ASN OXT    O N N 86  
ASN H      H N N 87  
ASN H2     H N N 88  
ASN HA     H N N 89  
ASN HB2    H N N 90  
ASN HB3    H N N 91  
ASN HD21   H N N 92  
ASN HD22   H N N 93  
ASN HXT    H N N 94  
ASP N      N N N 95  
ASP CA     C N S 96  
ASP C      C N N 97  
ASP O      O N N 98  
ASP CB     C N N 99  
ASP CG     C N N 100 
ASP OD1    O N N 101 
ASP OD2    O N N 102 
ASP OXT    O N N 103 
ASP H      H N N 104 
ASP H2     H N N 105 
ASP HA     H N N 106 
ASP HB2    H N N 107 
ASP HB3    H N N 108 
ASP HD2    H N N 109 
ASP HXT    H N N 110 
C   OP3    O N N 111 
C   P      P N N 112 
C   OP1    O N N 113 
C   OP2    O N N 114 
C   "O5'"  O N N 115 
C   "C5'"  C N N 116 
C   "C4'"  C N R 117 
C   "O4'"  O N N 118 
C   "C3'"  C N S 119 
C   "O3'"  O N N 120 
C   "C2'"  C N R 121 
C   "O2'"  O N N 122 
C   "C1'"  C N R 123 
C   N1     N N N 124 
C   C2     C N N 125 
C   O2     O N N 126 
C   N3     N N N 127 
C   C4     C N N 128 
C   N4     N N N 129 
C   C5     C N N 130 
C   C6     C N N 131 
C   HOP3   H N N 132 
C   HOP2   H N N 133 
C   "H5'"  H N N 134 
C   "H5''" H N N 135 
C   "H4'"  H N N 136 
C   "H3'"  H N N 137 
C   "HO3'" H N N 138 
C   "H2'"  H N N 139 
C   "HO2'" H N N 140 
C   "H1'"  H N N 141 
C   H41    H N N 142 
C   H42    H N N 143 
C   H5     H N N 144 
C   H6     H N N 145 
G   OP3    O N N 146 
G   P      P N N 147 
G   OP1    O N N 148 
G   OP2    O N N 149 
G   "O5'"  O N N 150 
G   "C5'"  C N N 151 
G   "C4'"  C N R 152 
G   "O4'"  O N N 153 
G   "C3'"  C N S 154 
G   "O3'"  O N N 155 
G   "C2'"  C N R 156 
G   "O2'"  O N N 157 
G   "C1'"  C N R 158 
G   N9     N Y N 159 
G   C8     C Y N 160 
G   N7     N Y N 161 
G   C5     C Y N 162 
G   C6     C N N 163 
G   O6     O N N 164 
G   N1     N N N 165 
G   C2     C N N 166 
G   N2     N N N 167 
G   N3     N N N 168 
G   C4     C Y N 169 
G   HOP3   H N N 170 
G   HOP2   H N N 171 
G   "H5'"  H N N 172 
G   "H5''" H N N 173 
G   "H4'"  H N N 174 
G   "H3'"  H N N 175 
G   "HO3'" H N N 176 
G   "H2'"  H N N 177 
G   "HO2'" H N N 178 
G   "H1'"  H N N 179 
G   H8     H N N 180 
G   H1     H N N 181 
G   H21    H N N 182 
G   H22    H N N 183 
GLN N      N N N 184 
GLN CA     C N S 185 
GLN C      C N N 186 
GLN O      O N N 187 
GLN CB     C N N 188 
GLN CG     C N N 189 
GLN CD     C N N 190 
GLN OE1    O N N 191 
GLN NE2    N N N 192 
GLN OXT    O N N 193 
GLN H      H N N 194 
GLN H2     H N N 195 
GLN HA     H N N 196 
GLN HB2    H N N 197 
GLN HB3    H N N 198 
GLN HG2    H N N 199 
GLN HG3    H N N 200 
GLN HE21   H N N 201 
GLN HE22   H N N 202 
GLN HXT    H N N 203 
GLU N      N N N 204 
GLU CA     C N S 205 
GLU C      C N N 206 
GLU O      O N N 207 
GLU CB     C N N 208 
GLU CG     C N N 209 
GLU CD     C N N 210 
GLU OE1    O N N 211 
GLU OE2    O N N 212 
GLU OXT    O N N 213 
GLU H      H N N 214 
GLU H2     H N N 215 
GLU HA     H N N 216 
GLU HB2    H N N 217 
GLU HB3    H N N 218 
GLU HG2    H N N 219 
GLU HG3    H N N 220 
GLU HE2    H N N 221 
GLU HXT    H N N 222 
GLY N      N N N 223 
GLY CA     C N N 224 
GLY C      C N N 225 
GLY O      O N N 226 
GLY OXT    O N N 227 
GLY H      H N N 228 
GLY H2     H N N 229 
GLY HA2    H N N 230 
GLY HA3    H N N 231 
GLY HXT    H N N 232 
HIS N      N N N 233 
HIS CA     C N S 234 
HIS C      C N N 235 
HIS O      O N N 236 
HIS CB     C N N 237 
HIS CG     C Y N 238 
HIS ND1    N Y N 239 
HIS CD2    C Y N 240 
HIS CE1    C Y N 241 
HIS NE2    N Y N 242 
HIS OXT    O N N 243 
HIS H      H N N 244 
HIS H2     H N N 245 
HIS HA     H N N 246 
HIS HB2    H N N 247 
HIS HB3    H N N 248 
HIS HD1    H N N 249 
HIS HD2    H N N 250 
HIS HE1    H N N 251 
HIS HE2    H N N 252 
HIS HXT    H N N 253 
HOH O      O N N 254 
HOH H1     H N N 255 
HOH H2     H N N 256 
ILE N      N N N 257 
ILE CA     C N S 258 
ILE C      C N N 259 
ILE O      O N N 260 
ILE CB     C N S 261 
ILE CG1    C N N 262 
ILE CG2    C N N 263 
ILE CD1    C N N 264 
ILE OXT    O N N 265 
ILE H      H N N 266 
ILE H2     H N N 267 
ILE HA     H N N 268 
ILE HB     H N N 269 
ILE HG12   H N N 270 
ILE HG13   H N N 271 
ILE HG21   H N N 272 
ILE HG22   H N N 273 
ILE HG23   H N N 274 
ILE HD11   H N N 275 
ILE HD12   H N N 276 
ILE HD13   H N N 277 
ILE HXT    H N N 278 
LEU N      N N N 279 
LEU CA     C N S 280 
LEU C      C N N 281 
LEU O      O N N 282 
LEU CB     C N N 283 
LEU CG     C N N 284 
LEU CD1    C N N 285 
LEU CD2    C N N 286 
LEU OXT    O N N 287 
LEU H      H N N 288 
LEU H2     H N N 289 
LEU HA     H N N 290 
LEU HB2    H N N 291 
LEU HB3    H N N 292 
LEU HG     H N N 293 
LEU HD11   H N N 294 
LEU HD12   H N N 295 
LEU HD13   H N N 296 
LEU HD21   H N N 297 
LEU HD22   H N N 298 
LEU HD23   H N N 299 
LEU HXT    H N N 300 
LYS N      N N N 301 
LYS CA     C N S 302 
LYS C      C N N 303 
LYS O      O N N 304 
LYS CB     C N N 305 
LYS CG     C N N 306 
LYS CD     C N N 307 
LYS CE     C N N 308 
LYS NZ     N N N 309 
LYS OXT    O N N 310 
LYS H      H N N 311 
LYS H2     H N N 312 
LYS HA     H N N 313 
LYS HB2    H N N 314 
LYS HB3    H N N 315 
LYS HG2    H N N 316 
LYS HG3    H N N 317 
LYS HD2    H N N 318 
LYS HD3    H N N 319 
LYS HE2    H N N 320 
LYS HE3    H N N 321 
LYS HZ1    H N N 322 
LYS HZ2    H N N 323 
LYS HZ3    H N N 324 
LYS HXT    H N N 325 
MET N      N N N 326 
MET CA     C N S 327 
MET C      C N N 328 
MET O      O N N 329 
MET CB     C N N 330 
MET CG     C N N 331 
MET SD     S N N 332 
MET CE     C N N 333 
MET OXT    O N N 334 
MET H      H N N 335 
MET H2     H N N 336 
MET HA     H N N 337 
MET HB2    H N N 338 
MET HB3    H N N 339 
MET HG2    H N N 340 
MET HG3    H N N 341 
MET HE1    H N N 342 
MET HE2    H N N 343 
MET HE3    H N N 344 
MET HXT    H N N 345 
PHE N      N N N 346 
PHE CA     C N S 347 
PHE C      C N N 348 
PHE O      O N N 349 
PHE CB     C N N 350 
PHE CG     C Y N 351 
PHE CD1    C Y N 352 
PHE CD2    C Y N 353 
PHE CE1    C Y N 354 
PHE CE2    C Y N 355 
PHE CZ     C Y N 356 
PHE OXT    O N N 357 
PHE H      H N N 358 
PHE H2     H N N 359 
PHE HA     H N N 360 
PHE HB2    H N N 361 
PHE HB3    H N N 362 
PHE HD1    H N N 363 
PHE HD2    H N N 364 
PHE HE1    H N N 365 
PHE HE2    H N N 366 
PHE HZ     H N N 367 
PHE HXT    H N N 368 
PRO N      N N N 369 
PRO CA     C N S 370 
PRO C      C N N 371 
PRO O      O N N 372 
PRO CB     C N N 373 
PRO CG     C N N 374 
PRO CD     C N N 375 
PRO OXT    O N N 376 
PRO H      H N N 377 
PRO HA     H N N 378 
PRO HB2    H N N 379 
PRO HB3    H N N 380 
PRO HG2    H N N 381 
PRO HG3    H N N 382 
PRO HD2    H N N 383 
PRO HD3    H N N 384 
PRO HXT    H N N 385 
SAH N      N N N 386 
SAH CA     C N S 387 
SAH CB     C N N 388 
SAH CG     C N N 389 
SAH SD     S N N 390 
SAH C      C N N 391 
SAH O      O N N 392 
SAH OXT    O N N 393 
SAH "C5'"  C N N 394 
SAH "C4'"  C N S 395 
SAH "O4'"  O N N 396 
SAH "C3'"  C N S 397 
SAH "O3'"  O N N 398 
SAH "C2'"  C N R 399 
SAH "O2'"  O N N 400 
SAH "C1'"  C N R 401 
SAH N9     N Y N 402 
SAH C8     C Y N 403 
SAH N7     N Y N 404 
SAH C5     C Y N 405 
SAH C6     C Y N 406 
SAH N6     N N N 407 
SAH N1     N Y N 408 
SAH C2     C Y N 409 
SAH N3     N Y N 410 
SAH C4     C Y N 411 
SAH HN1    H N N 412 
SAH HN2    H N N 413 
SAH HA     H N N 414 
SAH HB1    H N N 415 
SAH HB2    H N N 416 
SAH HG1    H N N 417 
SAH HG2    H N N 418 
SAH HXT    H N N 419 
SAH "H5'1" H N N 420 
SAH "H5'2" H N N 421 
SAH "H4'"  H N N 422 
SAH "H3'"  H N N 423 
SAH "HO3'" H N N 424 
SAH "H2'"  H N N 425 
SAH "HO2'" H N N 426 
SAH "H1'"  H N N 427 
SAH H8     H N N 428 
SAH HN61   H N N 429 
SAH HN62   H N N 430 
SAH H2     H N N 431 
SER N      N N N 432 
SER CA     C N S 433 
SER C      C N N 434 
SER O      O N N 435 
SER CB     C N N 436 
SER OG     O N N 437 
SER OXT    O N N 438 
SER H      H N N 439 
SER H2     H N N 440 
SER HA     H N N 441 
SER HB2    H N N 442 
SER HB3    H N N 443 
SER HG     H N N 444 
SER HXT    H N N 445 
THR N      N N N 446 
THR CA     C N S 447 
THR C      C N N 448 
THR O      O N N 449 
THR CB     C N R 450 
THR OG1    O N N 451 
THR CG2    C N N 452 
THR OXT    O N N 453 
THR H      H N N 454 
THR H2     H N N 455 
THR HA     H N N 456 
THR HB     H N N 457 
THR HG1    H N N 458 
THR HG21   H N N 459 
THR HG22   H N N 460 
THR HG23   H N N 461 
THR HXT    H N N 462 
TRP N      N N N 463 
TRP CA     C N S 464 
TRP C      C N N 465 
TRP O      O N N 466 
TRP CB     C N N 467 
TRP CG     C Y N 468 
TRP CD1    C Y N 469 
TRP CD2    C Y N 470 
TRP NE1    N Y N 471 
TRP CE2    C Y N 472 
TRP CE3    C Y N 473 
TRP CZ2    C Y N 474 
TRP CZ3    C Y N 475 
TRP CH2    C Y N 476 
TRP OXT    O N N 477 
TRP H      H N N 478 
TRP H2     H N N 479 
TRP HA     H N N 480 
TRP HB2    H N N 481 
TRP HB3    H N N 482 
TRP HD1    H N N 483 
TRP HE1    H N N 484 
TRP HE3    H N N 485 
TRP HZ2    H N N 486 
TRP HZ3    H N N 487 
TRP HH2    H N N 488 
TRP HXT    H N N 489 
TYR N      N N N 490 
TYR CA     C N S 491 
TYR C      C N N 492 
TYR O      O N N 493 
TYR CB     C N N 494 
TYR CG     C Y N 495 
TYR CD1    C Y N 496 
TYR CD2    C Y N 497 
TYR CE1    C Y N 498 
TYR CE2    C Y N 499 
TYR CZ     C Y N 500 
TYR OH     O N N 501 
TYR OXT    O N N 502 
TYR H      H N N 503 
TYR H2     H N N 504 
TYR HA     H N N 505 
TYR HB2    H N N 506 
TYR HB3    H N N 507 
TYR HD1    H N N 508 
TYR HD2    H N N 509 
TYR HE1    H N N 510 
TYR HE2    H N N 511 
TYR HH     H N N 512 
TYR HXT    H N N 513 
U   OP3    O N N 514 
U   P      P N N 515 
U   OP1    O N N 516 
U   OP2    O N N 517 
U   "O5'"  O N N 518 
U   "C5'"  C N N 519 
U   "C4'"  C N R 520 
U   "O4'"  O N N 521 
U   "C3'"  C N S 522 
U   "O3'"  O N N 523 
U   "C2'"  C N R 524 
U   "O2'"  O N N 525 
U   "C1'"  C N R 526 
U   N1     N N N 527 
U   C2     C N N 528 
U   O2     O N N 529 
U   N3     N N N 530 
U   C4     C N N 531 
U   O4     O N N 532 
U   C5     C N N 533 
U   C6     C N N 534 
U   HOP3   H N N 535 
U   HOP2   H N N 536 
U   "H5'"  H N N 537 
U   "H5''" H N N 538 
U   "H4'"  H N N 539 
U   "H3'"  H N N 540 
U   "HO3'" H N N 541 
U   "H2'"  H N N 542 
U   "HO2'" H N N 543 
U   "H1'"  H N N 544 
U   H3     H N N 545 
U   H5     H N N 546 
U   H6     H N N 547 
VAL N      N N N 548 
VAL CA     C N S 549 
VAL C      C N N 550 
VAL O      O N N 551 
VAL CB     C N N 552 
VAL CG1    C N N 553 
VAL CG2    C N N 554 
VAL OXT    O N N 555 
VAL H      H N N 556 
VAL H2     H N N 557 
VAL HA     H N N 558 
VAL HB     H N N 559 
VAL HG11   H N N 560 
VAL HG12   H N N 561 
VAL HG13   H N N 562 
VAL HG21   H N N 563 
VAL HG22   H N N 564 
VAL HG23   H N N 565 
VAL HXT    H N N 566 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A   OP3   P      sing N N 1   
A   OP3   HOP3   sing N N 2   
A   P     OP1    doub N N 3   
A   P     OP2    sing N N 4   
A   P     "O5'"  sing N N 5   
A   OP2   HOP2   sing N N 6   
A   "O5'" "C5'"  sing N N 7   
A   "C5'" "C4'"  sing N N 8   
A   "C5'" "H5'"  sing N N 9   
A   "C5'" "H5''" sing N N 10  
A   "C4'" "O4'"  sing N N 11  
A   "C4'" "C3'"  sing N N 12  
A   "C4'" "H4'"  sing N N 13  
A   "O4'" "C1'"  sing N N 14  
A   "C3'" "O3'"  sing N N 15  
A   "C3'" "C2'"  sing N N 16  
A   "C3'" "H3'"  sing N N 17  
A   "O3'" "HO3'" sing N N 18  
A   "C2'" "O2'"  sing N N 19  
A   "C2'" "C1'"  sing N N 20  
A   "C2'" "H2'"  sing N N 21  
A   "O2'" "HO2'" sing N N 22  
A   "C1'" N9     sing N N 23  
A   "C1'" "H1'"  sing N N 24  
A   N9    C8     sing Y N 25  
A   N9    C4     sing Y N 26  
A   C8    N7     doub Y N 27  
A   C8    H8     sing N N 28  
A   N7    C5     sing Y N 29  
A   C5    C6     sing Y N 30  
A   C5    C4     doub Y N 31  
A   C6    N6     sing N N 32  
A   C6    N1     doub Y N 33  
A   N6    H61    sing N N 34  
A   N6    H62    sing N N 35  
A   N1    C2     sing Y N 36  
A   C2    N3     doub Y N 37  
A   C2    H2     sing N N 38  
A   N3    C4     sing Y N 39  
ALA N     CA     sing N N 40  
ALA N     H      sing N N 41  
ALA N     H2     sing N N 42  
ALA CA    C      sing N N 43  
ALA CA    CB     sing N N 44  
ALA CA    HA     sing N N 45  
ALA C     O      doub N N 46  
ALA C     OXT    sing N N 47  
ALA CB    HB1    sing N N 48  
ALA CB    HB2    sing N N 49  
ALA CB    HB3    sing N N 50  
ALA OXT   HXT    sing N N 51  
ARG N     CA     sing N N 52  
ARG N     H      sing N N 53  
ARG N     H2     sing N N 54  
ARG CA    C      sing N N 55  
ARG CA    CB     sing N N 56  
ARG CA    HA     sing N N 57  
ARG C     O      doub N N 58  
ARG C     OXT    sing N N 59  
ARG CB    CG     sing N N 60  
ARG CB    HB2    sing N N 61  
ARG CB    HB3    sing N N 62  
ARG CG    CD     sing N N 63  
ARG CG    HG2    sing N N 64  
ARG CG    HG3    sing N N 65  
ARG CD    NE     sing N N 66  
ARG CD    HD2    sing N N 67  
ARG CD    HD3    sing N N 68  
ARG NE    CZ     sing N N 69  
ARG NE    HE     sing N N 70  
ARG CZ    NH1    sing N N 71  
ARG CZ    NH2    doub N N 72  
ARG NH1   HH11   sing N N 73  
ARG NH1   HH12   sing N N 74  
ARG NH2   HH21   sing N N 75  
ARG NH2   HH22   sing N N 76  
ARG OXT   HXT    sing N N 77  
ASN N     CA     sing N N 78  
ASN N     H      sing N N 79  
ASN N     H2     sing N N 80  
ASN CA    C      sing N N 81  
ASN CA    CB     sing N N 82  
ASN CA    HA     sing N N 83  
ASN C     O      doub N N 84  
ASN C     OXT    sing N N 85  
ASN CB    CG     sing N N 86  
ASN CB    HB2    sing N N 87  
ASN CB    HB3    sing N N 88  
ASN CG    OD1    doub N N 89  
ASN CG    ND2    sing N N 90  
ASN ND2   HD21   sing N N 91  
ASN ND2   HD22   sing N N 92  
ASN OXT   HXT    sing N N 93  
ASP N     CA     sing N N 94  
ASP N     H      sing N N 95  
ASP N     H2     sing N N 96  
ASP CA    C      sing N N 97  
ASP CA    CB     sing N N 98  
ASP CA    HA     sing N N 99  
ASP C     O      doub N N 100 
ASP C     OXT    sing N N 101 
ASP CB    CG     sing N N 102 
ASP CB    HB2    sing N N 103 
ASP CB    HB3    sing N N 104 
ASP CG    OD1    doub N N 105 
ASP CG    OD2    sing N N 106 
ASP OD2   HD2    sing N N 107 
ASP OXT   HXT    sing N N 108 
C   OP3   P      sing N N 109 
C   OP3   HOP3   sing N N 110 
C   P     OP1    doub N N 111 
C   P     OP2    sing N N 112 
C   P     "O5'"  sing N N 113 
C   OP2   HOP2   sing N N 114 
C   "O5'" "C5'"  sing N N 115 
C   "C5'" "C4'"  sing N N 116 
C   "C5'" "H5'"  sing N N 117 
C   "C5'" "H5''" sing N N 118 
C   "C4'" "O4'"  sing N N 119 
C   "C4'" "C3'"  sing N N 120 
C   "C4'" "H4'"  sing N N 121 
C   "O4'" "C1'"  sing N N 122 
C   "C3'" "O3'"  sing N N 123 
C   "C3'" "C2'"  sing N N 124 
C   "C3'" "H3'"  sing N N 125 
C   "O3'" "HO3'" sing N N 126 
C   "C2'" "O2'"  sing N N 127 
C   "C2'" "C1'"  sing N N 128 
C   "C2'" "H2'"  sing N N 129 
C   "O2'" "HO2'" sing N N 130 
C   "C1'" N1     sing N N 131 
C   "C1'" "H1'"  sing N N 132 
C   N1    C2     sing N N 133 
C   N1    C6     sing N N 134 
C   C2    O2     doub N N 135 
C   C2    N3     sing N N 136 
C   N3    C4     doub N N 137 
C   C4    N4     sing N N 138 
C   C4    C5     sing N N 139 
C   N4    H41    sing N N 140 
C   N4    H42    sing N N 141 
C   C5    C6     doub N N 142 
C   C5    H5     sing N N 143 
C   C6    H6     sing N N 144 
G   OP3   P      sing N N 145 
G   OP3   HOP3   sing N N 146 
G   P     OP1    doub N N 147 
G   P     OP2    sing N N 148 
G   P     "O5'"  sing N N 149 
G   OP2   HOP2   sing N N 150 
G   "O5'" "C5'"  sing N N 151 
G   "C5'" "C4'"  sing N N 152 
G   "C5'" "H5'"  sing N N 153 
G   "C5'" "H5''" sing N N 154 
G   "C4'" "O4'"  sing N N 155 
G   "C4'" "C3'"  sing N N 156 
G   "C4'" "H4'"  sing N N 157 
G   "O4'" "C1'"  sing N N 158 
G   "C3'" "O3'"  sing N N 159 
G   "C3'" "C2'"  sing N N 160 
G   "C3'" "H3'"  sing N N 161 
G   "O3'" "HO3'" sing N N 162 
G   "C2'" "O2'"  sing N N 163 
G   "C2'" "C1'"  sing N N 164 
G   "C2'" "H2'"  sing N N 165 
G   "O2'" "HO2'" sing N N 166 
G   "C1'" N9     sing N N 167 
G   "C1'" "H1'"  sing N N 168 
G   N9    C8     sing Y N 169 
G   N9    C4     sing Y N 170 
G   C8    N7     doub Y N 171 
G   C8    H8     sing N N 172 
G   N7    C5     sing Y N 173 
G   C5    C6     sing N N 174 
G   C5    C4     doub Y N 175 
G   C6    O6     doub N N 176 
G   C6    N1     sing N N 177 
G   N1    C2     sing N N 178 
G   N1    H1     sing N N 179 
G   C2    N2     sing N N 180 
G   C2    N3     doub N N 181 
G   N2    H21    sing N N 182 
G   N2    H22    sing N N 183 
G   N3    C4     sing N N 184 
GLN N     CA     sing N N 185 
GLN N     H      sing N N 186 
GLN N     H2     sing N N 187 
GLN CA    C      sing N N 188 
GLN CA    CB     sing N N 189 
GLN CA    HA     sing N N 190 
GLN C     O      doub N N 191 
GLN C     OXT    sing N N 192 
GLN CB    CG     sing N N 193 
GLN CB    HB2    sing N N 194 
GLN CB    HB3    sing N N 195 
GLN CG    CD     sing N N 196 
GLN CG    HG2    sing N N 197 
GLN CG    HG3    sing N N 198 
GLN CD    OE1    doub N N 199 
GLN CD    NE2    sing N N 200 
GLN NE2   HE21   sing N N 201 
GLN NE2   HE22   sing N N 202 
GLN OXT   HXT    sing N N 203 
GLU N     CA     sing N N 204 
GLU N     H      sing N N 205 
GLU N     H2     sing N N 206 
GLU CA    C      sing N N 207 
GLU CA    CB     sing N N 208 
GLU CA    HA     sing N N 209 
GLU C     O      doub N N 210 
GLU C     OXT    sing N N 211 
GLU CB    CG     sing N N 212 
GLU CB    HB2    sing N N 213 
GLU CB    HB3    sing N N 214 
GLU CG    CD     sing N N 215 
GLU CG    HG2    sing N N 216 
GLU CG    HG3    sing N N 217 
GLU CD    OE1    doub N N 218 
GLU CD    OE2    sing N N 219 
GLU OE2   HE2    sing N N 220 
GLU OXT   HXT    sing N N 221 
GLY N     CA     sing N N 222 
GLY N     H      sing N N 223 
GLY N     H2     sing N N 224 
GLY CA    C      sing N N 225 
GLY CA    HA2    sing N N 226 
GLY CA    HA3    sing N N 227 
GLY C     O      doub N N 228 
GLY C     OXT    sing N N 229 
GLY OXT   HXT    sing N N 230 
HIS N     CA     sing N N 231 
HIS N     H      sing N N 232 
HIS N     H2     sing N N 233 
HIS CA    C      sing N N 234 
HIS CA    CB     sing N N 235 
HIS CA    HA     sing N N 236 
HIS C     O      doub N N 237 
HIS C     OXT    sing N N 238 
HIS CB    CG     sing N N 239 
HIS CB    HB2    sing N N 240 
HIS CB    HB3    sing N N 241 
HIS CG    ND1    sing Y N 242 
HIS CG    CD2    doub Y N 243 
HIS ND1   CE1    doub Y N 244 
HIS ND1   HD1    sing N N 245 
HIS CD2   NE2    sing Y N 246 
HIS CD2   HD2    sing N N 247 
HIS CE1   NE2    sing Y N 248 
HIS CE1   HE1    sing N N 249 
HIS NE2   HE2    sing N N 250 
HIS OXT   HXT    sing N N 251 
HOH O     H1     sing N N 252 
HOH O     H2     sing N N 253 
ILE N     CA     sing N N 254 
ILE N     H      sing N N 255 
ILE N     H2     sing N N 256 
ILE CA    C      sing N N 257 
ILE CA    CB     sing N N 258 
ILE CA    HA     sing N N 259 
ILE C     O      doub N N 260 
ILE C     OXT    sing N N 261 
ILE CB    CG1    sing N N 262 
ILE CB    CG2    sing N N 263 
ILE CB    HB     sing N N 264 
ILE CG1   CD1    sing N N 265 
ILE CG1   HG12   sing N N 266 
ILE CG1   HG13   sing N N 267 
ILE CG2   HG21   sing N N 268 
ILE CG2   HG22   sing N N 269 
ILE CG2   HG23   sing N N 270 
ILE CD1   HD11   sing N N 271 
ILE CD1   HD12   sing N N 272 
ILE CD1   HD13   sing N N 273 
ILE OXT   HXT    sing N N 274 
LEU N     CA     sing N N 275 
LEU N     H      sing N N 276 
LEU N     H2     sing N N 277 
LEU CA    C      sing N N 278 
LEU CA    CB     sing N N 279 
LEU CA    HA     sing N N 280 
LEU C     O      doub N N 281 
LEU C     OXT    sing N N 282 
LEU CB    CG     sing N N 283 
LEU CB    HB2    sing N N 284 
LEU CB    HB3    sing N N 285 
LEU CG    CD1    sing N N 286 
LEU CG    CD2    sing N N 287 
LEU CG    HG     sing N N 288 
LEU CD1   HD11   sing N N 289 
LEU CD1   HD12   sing N N 290 
LEU CD1   HD13   sing N N 291 
LEU CD2   HD21   sing N N 292 
LEU CD2   HD22   sing N N 293 
LEU CD2   HD23   sing N N 294 
LEU OXT   HXT    sing N N 295 
LYS N     CA     sing N N 296 
LYS N     H      sing N N 297 
LYS N     H2     sing N N 298 
LYS CA    C      sing N N 299 
LYS CA    CB     sing N N 300 
LYS CA    HA     sing N N 301 
LYS C     O      doub N N 302 
LYS C     OXT    sing N N 303 
LYS CB    CG     sing N N 304 
LYS CB    HB2    sing N N 305 
LYS CB    HB3    sing N N 306 
LYS CG    CD     sing N N 307 
LYS CG    HG2    sing N N 308 
LYS CG    HG3    sing N N 309 
LYS CD    CE     sing N N 310 
LYS CD    HD2    sing N N 311 
LYS CD    HD3    sing N N 312 
LYS CE    NZ     sing N N 313 
LYS CE    HE2    sing N N 314 
LYS CE    HE3    sing N N 315 
LYS NZ    HZ1    sing N N 316 
LYS NZ    HZ2    sing N N 317 
LYS NZ    HZ3    sing N N 318 
LYS OXT   HXT    sing N N 319 
MET N     CA     sing N N 320 
MET N     H      sing N N 321 
MET N     H2     sing N N 322 
MET CA    C      sing N N 323 
MET CA    CB     sing N N 324 
MET CA    HA     sing N N 325 
MET C     O      doub N N 326 
MET C     OXT    sing N N 327 
MET CB    CG     sing N N 328 
MET CB    HB2    sing N N 329 
MET CB    HB3    sing N N 330 
MET CG    SD     sing N N 331 
MET CG    HG2    sing N N 332 
MET CG    HG3    sing N N 333 
MET SD    CE     sing N N 334 
MET CE    HE1    sing N N 335 
MET CE    HE2    sing N N 336 
MET CE    HE3    sing N N 337 
MET OXT   HXT    sing N N 338 
PHE N     CA     sing N N 339 
PHE N     H      sing N N 340 
PHE N     H2     sing N N 341 
PHE CA    C      sing N N 342 
PHE CA    CB     sing N N 343 
PHE CA    HA     sing N N 344 
PHE C     O      doub N N 345 
PHE C     OXT    sing N N 346 
PHE CB    CG     sing N N 347 
PHE CB    HB2    sing N N 348 
PHE CB    HB3    sing N N 349 
PHE CG    CD1    doub Y N 350 
PHE CG    CD2    sing Y N 351 
PHE CD1   CE1    sing Y N 352 
PHE CD1   HD1    sing N N 353 
PHE CD2   CE2    doub Y N 354 
PHE CD2   HD2    sing N N 355 
PHE CE1   CZ     doub Y N 356 
PHE CE1   HE1    sing N N 357 
PHE CE2   CZ     sing Y N 358 
PHE CE2   HE2    sing N N 359 
PHE CZ    HZ     sing N N 360 
PHE OXT   HXT    sing N N 361 
PRO N     CA     sing N N 362 
PRO N     CD     sing N N 363 
PRO N     H      sing N N 364 
PRO CA    C      sing N N 365 
PRO CA    CB     sing N N 366 
PRO CA    HA     sing N N 367 
PRO C     O      doub N N 368 
PRO C     OXT    sing N N 369 
PRO CB    CG     sing N N 370 
PRO CB    HB2    sing N N 371 
PRO CB    HB3    sing N N 372 
PRO CG    CD     sing N N 373 
PRO CG    HG2    sing N N 374 
PRO CG    HG3    sing N N 375 
PRO CD    HD2    sing N N 376 
PRO CD    HD3    sing N N 377 
PRO OXT   HXT    sing N N 378 
SAH N     CA     sing N N 379 
SAH N     HN1    sing N N 380 
SAH N     HN2    sing N N 381 
SAH CA    CB     sing N N 382 
SAH CA    C      sing N N 383 
SAH CA    HA     sing N N 384 
SAH CB    CG     sing N N 385 
SAH CB    HB1    sing N N 386 
SAH CB    HB2    sing N N 387 
SAH CG    SD     sing N N 388 
SAH CG    HG1    sing N N 389 
SAH CG    HG2    sing N N 390 
SAH SD    "C5'"  sing N N 391 
SAH C     O      doub N N 392 
SAH C     OXT    sing N N 393 
SAH OXT   HXT    sing N N 394 
SAH "C5'" "C4'"  sing N N 395 
SAH "C5'" "H5'1" sing N N 396 
SAH "C5'" "H5'2" sing N N 397 
SAH "C4'" "O4'"  sing N N 398 
SAH "C4'" "C3'"  sing N N 399 
SAH "C4'" "H4'"  sing N N 400 
SAH "O4'" "C1'"  sing N N 401 
SAH "C3'" "O3'"  sing N N 402 
SAH "C3'" "C2'"  sing N N 403 
SAH "C3'" "H3'"  sing N N 404 
SAH "O3'" "HO3'" sing N N 405 
SAH "C2'" "O2'"  sing N N 406 
SAH "C2'" "C1'"  sing N N 407 
SAH "C2'" "H2'"  sing N N 408 
SAH "O2'" "HO2'" sing N N 409 
SAH "C1'" N9     sing N N 410 
SAH "C1'" "H1'"  sing N N 411 
SAH N9    C8     sing Y N 412 
SAH N9    C4     sing Y N 413 
SAH C8    N7     doub Y N 414 
SAH C8    H8     sing N N 415 
SAH N7    C5     sing Y N 416 
SAH C5    C6     sing Y N 417 
SAH C5    C4     doub Y N 418 
SAH C6    N6     sing N N 419 
SAH C6    N1     doub Y N 420 
SAH N6    HN61   sing N N 421 
SAH N6    HN62   sing N N 422 
SAH N1    C2     sing Y N 423 
SAH C2    N3     doub Y N 424 
SAH C2    H2     sing N N 425 
SAH N3    C4     sing Y N 426 
SER N     CA     sing N N 427 
SER N     H      sing N N 428 
SER N     H2     sing N N 429 
SER CA    C      sing N N 430 
SER CA    CB     sing N N 431 
SER CA    HA     sing N N 432 
SER C     O      doub N N 433 
SER C     OXT    sing N N 434 
SER CB    OG     sing N N 435 
SER CB    HB2    sing N N 436 
SER CB    HB3    sing N N 437 
SER OG    HG     sing N N 438 
SER OXT   HXT    sing N N 439 
THR N     CA     sing N N 440 
THR N     H      sing N N 441 
THR N     H2     sing N N 442 
THR CA    C      sing N N 443 
THR CA    CB     sing N N 444 
THR CA    HA     sing N N 445 
THR C     O      doub N N 446 
THR C     OXT    sing N N 447 
THR CB    OG1    sing N N 448 
THR CB    CG2    sing N N 449 
THR CB    HB     sing N N 450 
THR OG1   HG1    sing N N 451 
THR CG2   HG21   sing N N 452 
THR CG2   HG22   sing N N 453 
THR CG2   HG23   sing N N 454 
THR OXT   HXT    sing N N 455 
TRP N     CA     sing N N 456 
TRP N     H      sing N N 457 
TRP N     H2     sing N N 458 
TRP CA    C      sing N N 459 
TRP CA    CB     sing N N 460 
TRP CA    HA     sing N N 461 
TRP C     O      doub N N 462 
TRP C     OXT    sing N N 463 
TRP CB    CG     sing N N 464 
TRP CB    HB2    sing N N 465 
TRP CB    HB3    sing N N 466 
TRP CG    CD1    doub Y N 467 
TRP CG    CD2    sing Y N 468 
TRP CD1   NE1    sing Y N 469 
TRP CD1   HD1    sing N N 470 
TRP CD2   CE2    doub Y N 471 
TRP CD2   CE3    sing Y N 472 
TRP NE1   CE2    sing Y N 473 
TRP NE1   HE1    sing N N 474 
TRP CE2   CZ2    sing Y N 475 
TRP CE3   CZ3    doub Y N 476 
TRP CE3   HE3    sing N N 477 
TRP CZ2   CH2    doub Y N 478 
TRP CZ2   HZ2    sing N N 479 
TRP CZ3   CH2    sing Y N 480 
TRP CZ3   HZ3    sing N N 481 
TRP CH2   HH2    sing N N 482 
TRP OXT   HXT    sing N N 483 
TYR N     CA     sing N N 484 
TYR N     H      sing N N 485 
TYR N     H2     sing N N 486 
TYR CA    C      sing N N 487 
TYR CA    CB     sing N N 488 
TYR CA    HA     sing N N 489 
TYR C     O      doub N N 490 
TYR C     OXT    sing N N 491 
TYR CB    CG     sing N N 492 
TYR CB    HB2    sing N N 493 
TYR CB    HB3    sing N N 494 
TYR CG    CD1    doub Y N 495 
TYR CG    CD2    sing Y N 496 
TYR CD1   CE1    sing Y N 497 
TYR CD1   HD1    sing N N 498 
TYR CD2   CE2    doub Y N 499 
TYR CD2   HD2    sing N N 500 
TYR CE1   CZ     doub Y N 501 
TYR CE1   HE1    sing N N 502 
TYR CE2   CZ     sing Y N 503 
TYR CE2   HE2    sing N N 504 
TYR CZ    OH     sing N N 505 
TYR OH    HH     sing N N 506 
TYR OXT   HXT    sing N N 507 
U   OP3   P      sing N N 508 
U   OP3   HOP3   sing N N 509 
U   P     OP1    doub N N 510 
U   P     OP2    sing N N 511 
U   P     "O5'"  sing N N 512 
U   OP2   HOP2   sing N N 513 
U   "O5'" "C5'"  sing N N 514 
U   "C5'" "C4'"  sing N N 515 
U   "C5'" "H5'"  sing N N 516 
U   "C5'" "H5''" sing N N 517 
U   "C4'" "O4'"  sing N N 518 
U   "C4'" "C3'"  sing N N 519 
U   "C4'" "H4'"  sing N N 520 
U   "O4'" "C1'"  sing N N 521 
U   "C3'" "O3'"  sing N N 522 
U   "C3'" "C2'"  sing N N 523 
U   "C3'" "H3'"  sing N N 524 
U   "O3'" "HO3'" sing N N 525 
U   "C2'" "O2'"  sing N N 526 
U   "C2'" "C1'"  sing N N 527 
U   "C2'" "H2'"  sing N N 528 
U   "O2'" "HO2'" sing N N 529 
U   "C1'" N1     sing N N 530 
U   "C1'" "H1'"  sing N N 531 
U   N1    C2     sing N N 532 
U   N1    C6     sing N N 533 
U   C2    O2     doub N N 534 
U   C2    N3     sing N N 535 
U   N3    C4     sing N N 536 
U   N3    H3     sing N N 537 
U   C4    O4     doub N N 538 
U   C4    C5     sing N N 539 
U   C5    C6     doub N N 540 
U   C5    H5     sing N N 541 
U   C6    H6     sing N N 542 
VAL N     CA     sing N N 543 
VAL N     H      sing N N 544 
VAL N     H2     sing N N 545 
VAL CA    C      sing N N 546 
VAL CA    CB     sing N N 547 
VAL CA    HA     sing N N 548 
VAL C     O      doub N N 549 
VAL C     OXT    sing N N 550 
VAL CB    CG1    sing N N 551 
VAL CB    CG2    sing N N 552 
VAL CB    HB     sing N N 553 
VAL CG1   HG11   sing N N 554 
VAL CG1   HG12   sing N N 555 
VAL CG1   HG13   sing N N 556 
VAL CG2   HG21   sing N N 557 
VAL CG2   HG22   sing N N 558 
VAL CG2   HG23   sing N N 559 
VAL OXT   HXT    sing N N 560 
# 
_ndb_struct_conf_na.entry_id   9H1K 
_ndb_struct_conf_na.feature    'a-form double helix' 
# 
loop_
_ndb_struct_na_base_pair.model_number 
_ndb_struct_na_base_pair.i_label_asym_id 
_ndb_struct_na_base_pair.i_label_comp_id 
_ndb_struct_na_base_pair.i_label_seq_id 
_ndb_struct_na_base_pair.i_symmetry 
_ndb_struct_na_base_pair.j_label_asym_id 
_ndb_struct_na_base_pair.j_label_comp_id 
_ndb_struct_na_base_pair.j_label_seq_id 
_ndb_struct_na_base_pair.j_symmetry 
_ndb_struct_na_base_pair.shear 
_ndb_struct_na_base_pair.stretch 
_ndb_struct_na_base_pair.stagger 
_ndb_struct_na_base_pair.buckle 
_ndb_struct_na_base_pair.propeller 
_ndb_struct_na_base_pair.opening 
_ndb_struct_na_base_pair.pair_number 
_ndb_struct_na_base_pair.pair_name 
_ndb_struct_na_base_pair.i_auth_asym_id 
_ndb_struct_na_base_pair.i_auth_seq_id 
_ndb_struct_na_base_pair.i_PDB_ins_code 
_ndb_struct_na_base_pair.j_auth_asym_id 
_ndb_struct_na_base_pair.j_auth_seq_id 
_ndb_struct_na_base_pair.j_PDB_ins_code 
_ndb_struct_na_base_pair.hbond_type_28 
_ndb_struct_na_base_pair.hbond_type_12 
1 C G 1  1_555 C C 59 1_555 -0.669 -0.352 0.126  -0.836  -13.003 -1.631 1  C_G2513:C2571_C C 2513 ? C 2571 ? 19 1 
1 C U 2  1_555 C G 58 1_555 1.594  -0.467 0.067  2.198   -12.261 2.955  2  C_U2514:G2570_C C 2514 ? C 2570 ? 28 1 
1 C C 3  1_555 C G 57 1_555 1.070  -0.488 0.069  -2.184  -5.177  0.382  3  C_C2515:G2569_C C 2515 ? C 2569 ? 19 1 
1 C G 4  1_555 C C 56 1_555 -1.139 -0.521 0.285  4.571   -7.305  -0.780 4  C_G2516:C2568_C C 2516 ? C 2568 ? 19 1 
1 C C 5  1_555 C G 55 1_555 0.552  -0.270 0.049  8.255   -10.544 -0.054 5  C_C2517:G2567_C C 2517 ? C 2567 ? 19 1 
1 C A 6  1_555 C U 34 1_555 -0.525 -0.482 0.647  2.116   -10.532 -3.563 6  C_A2518:U2546_C C 2518 ? C 2546 ? 20 1 
1 C U 7  1_555 C G 33 1_555 1.850  -0.738 0.524  5.079   -12.084 -4.044 7  C_U2519:G2545_C C 2519 ? C 2545 ? 28 1 
1 C C 8  1_555 C G 32 1_555 0.989  -0.549 0.518  6.340   -22.111 -3.326 8  C_C2520:G2544_C C 2520 ? C 2544 ? 19 1 
1 C U 35 1_555 C A 49 1_555 0.061  -0.193 -0.016 -0.017  -10.475 -1.625 9  C_U2547:A2561_C C 2547 ? C 2561 ? 20 1 
1 C G 36 1_555 C C 48 1_555 -0.661 -0.303 0.036  -3.601  -5.119  -1.343 10 C_G2548:C2560_C C 2548 ? C 2560 ? 19 1 
1 C G 37 1_555 C C 47 1_555 -0.413 -0.285 -0.032 1.247   -6.638  -0.207 11 C_G2549:C2559_C C 2549 ? C 2559 ? 19 1 
1 C G 38 1_555 C C 46 1_555 -0.423 -0.219 -0.069 -9.375  -14.405 2.059  12 C_G2550:C2558_C C 2550 ? C 2558 ? 19 1 
1 C C 39 1_555 C G 45 1_555 0.156  -0.115 0.481  -11.536 -5.342  1.772  13 C_C2551:G2557_C C 2551 ? C 2557 ? 19 1 
# 
loop_
_ndb_struct_na_base_pair_step.model_number 
_ndb_struct_na_base_pair_step.i_label_asym_id_1 
_ndb_struct_na_base_pair_step.i_label_comp_id_1 
_ndb_struct_na_base_pair_step.i_label_seq_id_1 
_ndb_struct_na_base_pair_step.i_symmetry_1 
_ndb_struct_na_base_pair_step.j_label_asym_id_1 
_ndb_struct_na_base_pair_step.j_label_comp_id_1 
_ndb_struct_na_base_pair_step.j_label_seq_id_1 
_ndb_struct_na_base_pair_step.j_symmetry_1 
_ndb_struct_na_base_pair_step.i_label_asym_id_2 
_ndb_struct_na_base_pair_step.i_label_comp_id_2 
_ndb_struct_na_base_pair_step.i_label_seq_id_2 
_ndb_struct_na_base_pair_step.i_symmetry_2 
_ndb_struct_na_base_pair_step.j_label_asym_id_2 
_ndb_struct_na_base_pair_step.j_label_comp_id_2 
_ndb_struct_na_base_pair_step.j_label_seq_id_2 
_ndb_struct_na_base_pair_step.j_symmetry_2 
_ndb_struct_na_base_pair_step.shift 
_ndb_struct_na_base_pair_step.slide 
_ndb_struct_na_base_pair_step.rise 
_ndb_struct_na_base_pair_step.tilt 
_ndb_struct_na_base_pair_step.roll 
_ndb_struct_na_base_pair_step.twist 
_ndb_struct_na_base_pair_step.x_displacement 
_ndb_struct_na_base_pair_step.y_displacement 
_ndb_struct_na_base_pair_step.helical_rise 
_ndb_struct_na_base_pair_step.inclination 
_ndb_struct_na_base_pair_step.tip 
_ndb_struct_na_base_pair_step.helical_twist 
_ndb_struct_na_base_pair_step.step_number 
_ndb_struct_na_base_pair_step.step_name 
_ndb_struct_na_base_pair_step.i_auth_asym_id_1 
_ndb_struct_na_base_pair_step.i_auth_seq_id_1 
_ndb_struct_na_base_pair_step.i_PDB_ins_code_1 
_ndb_struct_na_base_pair_step.j_auth_asym_id_1 
_ndb_struct_na_base_pair_step.j_auth_seq_id_1 
_ndb_struct_na_base_pair_step.j_PDB_ins_code_1 
_ndb_struct_na_base_pair_step.i_auth_asym_id_2 
_ndb_struct_na_base_pair_step.i_auth_seq_id_2 
_ndb_struct_na_base_pair_step.i_PDB_ins_code_2 
_ndb_struct_na_base_pair_step.j_auth_asym_id_2 
_ndb_struct_na_base_pair_step.j_auth_seq_id_2 
_ndb_struct_na_base_pair_step.j_PDB_ins_code_2 
1 C G 1  1_555 C C 59 1_555 C U 2  1_555 C G 58 1_555 0.378  -1.438 3.285 0.754  -0.393 41.665 -1.979 -0.451 3.304 -0.552 -1.061 
41.673 1  CC_G2513U2514:G2570C2571_CC C 2513 ? C 2571 ? C 2514 ? C 2570 ? 
1 C U 2  1_555 C G 58 1_555 C C 3  1_555 C G 57 1_555 -0.395 -1.844 3.259 1.154  4.435  32.570 -3.984 0.887  2.973 7.860  -2.045 
32.882 2  CC_U2514C2515:G2569G2570_CC C 2514 ? C 2570 ? C 2515 ? C 2569 ? 
1 C C 3  1_555 C G 57 1_555 C G 4  1_555 C C 56 1_555 -0.395 -2.075 2.993 -1.981 3.171  15.695 -9.352 0.185  2.555 11.404 7.123  
16.131 3  CC_C2515G2516:C2568G2569_CC C 2515 ? C 2569 ? C 2516 ? C 2568 ? 
1 C G 4  1_555 C C 56 1_555 C C 5  1_555 C G 55 1_555 0.358  -1.377 3.181 1.006  -0.083 42.480 -1.892 -0.395 3.191 -0.115 -1.388 
42.492 4  CC_G2516C2517:G2567C2568_CC C 2516 ? C 2568 ? C 2517 ? C 2567 ? 
1 C C 5  1_555 C G 55 1_555 C A 6  1_555 C U 34 1_555 1.317  -1.658 3.152 -2.657 2.216  38.150 -2.788 -2.320 2.959 3.383  4.055  
38.301 5  CC_C2517A2518:U2546G2567_CC C 2517 ? C 2567 ? C 2518 ? C 2546 ? 
1 C A 6  1_555 C U 34 1_555 C U 7  1_555 C G 33 1_555 -0.121 -1.640 3.241 0.597  0.661  41.610 -2.378 0.233  3.214 0.931  -0.840 
41.619 6  CC_A2518U2519:G2545U2546_CC C 2518 ? C 2546 ? C 2519 ? C 2545 ? 
1 C U 7  1_555 C G 33 1_555 C C 8  1_555 C G 32 1_555 0.022  -1.980 3.073 0.815  1.503  33.012 -3.716 0.089  2.982 2.644  -1.433 
33.055 7  CC_U2519C2520:G2544G2545_CC C 2519 ? C 2545 ? C 2520 ? C 2544 ? 
1 C U 35 1_555 C A 49 1_555 C G 36 1_555 C C 48 1_555 0.211  -1.725 3.284 -1.561 5.636  28.772 -4.561 -0.737 2.885 11.196 3.100  
29.348 8  CC_U2547G2548:C2560A2561_CC C 2547 ? C 2561 ? C 2548 ? C 2560 ? 
1 C G 36 1_555 C C 48 1_555 C G 37 1_555 C C 47 1_555 0.470  -2.138 3.180 0.634  4.354  26.327 -5.679 -0.865 2.806 9.475  -1.381 
26.685 9  CC_G2548G2549:C2559C2560_CC C 2548 ? C 2560 ? C 2549 ? C 2559 ? 
1 C G 37 1_555 C C 47 1_555 C G 38 1_555 C C 46 1_555 0.444  -2.068 3.533 0.903  4.823  32.192 -4.561 -0.628 3.208 8.636  -1.617 
32.554 10 CC_G2549G2550:C2558C2559_CC C 2549 ? C 2559 ? C 2550 ? C 2558 ? 
1 C G 38 1_555 C C 46 1_555 C C 39 1_555 C G 45 1_555 0.274  -2.071 3.374 -0.434 -2.015 36.349 -3.022 -0.501 3.477 -3.228 0.696  
36.405 11 CC_G2550C2551:G2557C2558_CC C 2550 ? C 2558 ? C 2551 ? C 2557 ? 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Fonds National de la Recherche Scientifique (FNRS)' Belgium 'FNRS BAG 20210875' 1 
'Fonds National de la Recherche Scientifique (FNRS)' Belgium 'FNRS BAG 20191372' 2 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   4x3m 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9H1K 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.008846 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.008516 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.017167 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
P 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N     . HIS A 1 20  ? 18.30600  19.47200  18.74200  1.000 66.86083  ? 0    HIS A N     1 
ATOM   2    C CA    . HIS A 1 20  ? 19.18400  18.45800  18.16300  1.000 72.82196  ? 0    HIS A CA    1 
ATOM   3    C C     . HIS A 1 20  ? 18.58100  17.05500  18.26900  1.000 74.38058  ? 0    HIS A C     1 
ATOM   4    O O     . HIS A 1 20  ? 18.88500  16.30800  19.20400  1.000 73.66589  ? 0    HIS A O     1 
ATOM   5    C CB    . HIS A 1 20  ? 20.55600  18.49200  18.84500  1.000 72.92388  ? 0    HIS A CB    1 
ATOM   6    N N     . MET A 1 21  ? 17.71800  16.71100  17.30900  1.000 72.86716  ? 1    MET A N     1 
ATOM   7    C CA    . MET A 1 21  ? 17.12900  15.38000  17.21100  1.000 72.03628  ? 1    MET A CA    1 
ATOM   8    C C     . MET A 1 21  ? 16.74300  15.11100  15.76500  1.000 69.94620  ? 1    MET A C     1 
ATOM   9    O O     . MET A 1 21  ? 16.40100  16.02900  15.01400  1.000 65.36878  ? 1    MET A O     1 
ATOM   10   C CB    . MET A 1 21  ? 15.88700  15.20800  18.10400  1.000 75.49232  ? 1    MET A CB    1 
ATOM   11   C CG    . MET A 1 21  ? 16.18000  14.81200  19.54000  1.000 80.06916  ? 1    MET A CG    1 
ATOM   12   S SD    . MET A 1 21  ? 14.80800  15.20100  20.64600  1.000 95.92703  ? 1    MET A SD    1 
ATOM   13   C CE    . MET A 1 21  ? 15.71400  15.49200  22.16900  1.000 85.64129  ? 1    MET A CE    1 
ATOM   14   N N     . ARG A 1 22  ? 16.71800  13.82900  15.41900  1.000 76.58807  ? 2    ARG A N     1 
ATOM   15   C CA    . ARG A 1 22  ? 16.23500  13.42600  14.08200  1.000 70.89742  ? 2    ARG A CA    1 
ATOM   16   C C     . ARG A 1 22  ? 15.01200  12.56100  14.35600  1.000 72.63522  ? 2    ARG A C     1 
ATOM   17   O O     . ARG A 1 22  ? 15.13400  11.60000  15.12800  1.000 79.77742  ? 2    ARG A O     1 
ATOM   18   C CB    . ARG A 1 22  ? 17.28000  12.68300  13.25200  1.000 77.86504  ? 2    ARG A CB    1 
ATOM   19   C CG    . ARG A 1 22  ? 18.45700  13.55900  12.85200  1.000 82.75739  ? 2    ARG A CG    1 
ATOM   20   C CD    . ARG A 1 22  ? 19.43900  12.78600  11.99000  1.000 87.82360  ? 2    ARG A CD    1 
ATOM   21   N NE    . ARG A 1 22  ? 20.61100  13.59900  11.65800  1.000 96.38757  ? 2    ARG A NE    1 
ATOM   22   C CZ    . ARG A 1 22  ? 21.67700  13.14500  11.01500  1.000 102.94867 ? 2    ARG A CZ    1 
ATOM   23   N NH1   . ARG A 1 22  ? 21.61600  12.92000  9.71600   1.000 103.54726 ? 2    ARG A NH1   1 
ATOM   24   N NH2   . ARG A 1 22  ? 22.79900  12.91600  11.67300  1.000 104.07255 ? 2    ARG A NH2   1 
ATOM   25   N N     . ILE A 1 23  ? 13.87800  12.93500  13.80000  1.000 68.05146  ? 3    ILE A N     1 
ATOM   26   C CA    . ILE A 1 23  ? 12.62100  12.22800  13.97200  1.000 67.08227  ? 3    ILE A CA    1 
ATOM   27   C C     . ILE A 1 23  ? 12.26300  11.62000  12.63200  1.000 67.29336  ? 3    ILE A C     1 
ATOM   28   O O     . ILE A 1 23  ? 12.27400  12.31500  11.61000  1.000 61.54115  ? 3    ILE A O     1 
ATOM   29   C CB    . ILE A 1 23  ? 11.50200  13.15000  14.48100  1.000 62.49429  ? 3    ILE A CB    1 
ATOM   30   C CG1   . ILE A 1 23  ? 11.87200  13.71400  15.85000  1.000 69.80846  ? 3    ILE A CG1   1 
ATOM   31   C CG2   . ILE A 1 23  ? 10.19600  12.38500  14.57100  1.000 64.31767  ? 3    ILE A CG2   1 
ATOM   32   C CD1   . ILE A 1 23  ? 10.78200  14.57300  16.47100  1.000 67.08124  ? 3    ILE A CD1   1 
ATOM   33   N N     . GLU A 1 24  ? 11.97100  10.32200  12.63600  1.000 70.64054  ? 4    GLU A N     1 
ATOM   34   C CA    . GLU A 1 24  ? 11.58900  9.60200   11.43000  1.000 67.12049  ? 4    GLU A CA    1 
ATOM   35   C C     . GLU A 1 24  ? 10.15500  9.10500   11.46100  1.000 65.22120  ? 4    GLU A C     1 
ATOM   36   O O     . GLU A 1 24  ? 9.46200   9.19100   10.44500  1.000 62.21070  ? 4    GLU A O     1 
ATOM   37   C CB    . GLU A 1 24  ? 12.53100  8.41700   11.20700  1.000 74.23545  ? 4    GLU A CB    1 
ATOM   38   C CG    . GLU A 1 24  ? 14.00400  8.74400   11.45700  1.000 81.38483  ? 4    GLU A CG    1 
ATOM   39   C CD    . GLU A 1 24  ? 14.87300  8.61400   10.20600  1.000 86.57758  ? 4    GLU A CD    1 
ATOM   40   O OE1   . GLU A 1 24  ? 14.32100  8.69700   9.07900   1.000 81.28921  ? 4    GLU A OE1   1 
ATOM   41   O OE2   . GLU A 1 24  ? 16.10500  8.42700   10.35700  1.000 87.92085  ? 4    GLU A OE2   1 
ATOM   42   N N     . SER A 1 25  ? 9.68300   8.60200   12.60400  1.000 67.43620  ? 5    SER A N     1 
ATOM   43   C CA    . SER A 1 25  ? 8.36600   7.97100   12.66100  1.000 67.27598  ? 5    SER A CA    1 
ATOM   44   C C     . SER A 1 25  ? 7.26600   9.02000   12.68200  1.000 66.08465  ? 5    SER A C     1 
ATOM   45   O O     . SER A 1 25  ? 7.26300   9.88000   13.57000  1.000 61.20965  ? 5    SER A O     1 
ATOM   46   C CB    . SER A 1 25  ? 8.22700   7.09100   13.89400  1.000 67.94875  ? 5    SER A CB    1 
ATOM   47   O OG    . SER A 1 25  ? 6.85300   6.81700   14.13500  1.000 65.00361  ? 5    SER A OG    1 
ATOM   48   N N     . PRO A 1 26  ? 6.30800   8.97600   11.75500  1.000 64.98415  ? 6    PRO A N     1 
ATOM   49   C CA    . PRO A 1 26  ? 5.14000   9.86300   11.86400  1.000 62.96712  ? 6    PRO A CA    1 
ATOM   50   C C     . PRO A 1 26  ? 4.39500   9.70000   13.16900  1.000 69.06488  ? 6    PRO A C     1 
ATOM   51   O O     . PRO A 1 26  ? 3.63500   10.60200  13.55500  1.000 69.28303  ? 6    PRO A O     1 
ATOM   52   C CB    . PRO A 1 26  ? 4.27100   9.45100   10.67300  1.000 65.27817  ? 6    PRO A CB    1 
ATOM   53   C CG    . PRO A 1 26  ? 5.23400   8.82900   9.70700   1.000 65.65090  ? 6    PRO A CG    1 
ATOM   54   C CD    . PRO A 1 26  ? 6.29800   8.17500   10.52000  1.000 63.65018  ? 6    PRO A CD    1 
ATOM   55   N N     . GLN A 1 27  ? 4.59800   8.58500   13.86900  1.000 70.91126  ? 7    GLN A N     1 
ATOM   56   C CA    . GLN A 1 27  ? 3.94100   8.31400   15.14000  1.000 70.00161  ? 7    GLN A CA    1 
ATOM   57   C C     . GLN A 1 27  ? 4.80100   8.69100   16.34400  1.000 69.43916  ? 7    GLN A C     1 
ATOM   58   O O     . GLN A 1 27  ? 4.44700   8.33600   17.47500  1.000 72.07548  ? 7    GLN A O     1 
ATOM   59   C CB    . GLN A 1 27  ? 3.54400   6.83100   15.21300  1.000 73.61769  ? 7    GLN A CB    1 
ATOM   60   C CG    . GLN A 1 27  ? 2.75800   6.33900   13.98500  1.000 69.54284  ? 7    GLN A CG    1 
ATOM   61   C CD    . GLN A 1 27  ? 1.42700   7.06500   13.81100  1.000 71.74758  ? 7    GLN A CD    1 
ATOM   62   O OE1   . GLN A 1 27  ? 0.74100   7.36400   14.79400  1.000 69.89372  ? 7    GLN A OE1   1 
ATOM   63   N NE2   . GLN A 1 27  ? 1.05800   7.35600   12.55800  1.000 62.81335  ? 7    GLN A NE2   1 
ATOM   64   N N     . ASN A 1 28  ? 5.91500   9.39100   16.12700  1.000 67.21523  ? 8    ASN A N     1 
ATOM   65   C CA    . ASN A 1 28  ? 6.72900   9.87500   17.23400  1.000 66.05629  ? 8    ASN A CA    1 
ATOM   66   C C     . ASN A 1 28  ? 5.91600   10.85300  18.08700  1.000 68.32218  ? 8    ASN A C     1 
ATOM   67   O O     . ASN A 1 28  ? 5.08400   11.60200  17.55100  1.000 64.16600  ? 8    ASN A O     1 
ATOM   68   C CB    . ASN A 1 28  ? 7.99900   10.53700  16.68900  1.000 66.95879  ? 8    ASN A CB    1 
ATOM   69   C CG    . ASN A 1 28  ? 8.76100   11.32000  17.73800  1.000 68.59465  ? 8    ASN A CG    1 
ATOM   70   O OD1   . ASN A 1 28  ? 8.39300   12.44200  18.06400  1.000 72.27813  ? 8    ASN A OD1   1 
ATOM   71   N ND2   . ASN A 1 28  ? 9.84400   10.74400  18.25300  1.000 69.73059  ? 8    ASN A ND2   1 
ATOM   72   N N     . PRO A 1 29  ? 6.10200   10.85500  19.41500  1.000 69.08347  ? 9    PRO A N     1 
ATOM   73   C CA    . PRO A 1 29  ? 5.26100   11.72300  20.26800  1.000 70.40453  ? 9    PRO A CA    1 
ATOM   74   C C     . PRO A 1 29  ? 5.35600   13.20800  19.93400  1.000 66.20169  ? 9    PRO A C     1 
ATOM   75   O O     . PRO A 1 29  ? 4.33800   13.91700  19.97800  1.000 62.10452  ? 9    PRO A O     1 
ATOM   76   C CB    . PRO A 1 29  ? 5.77900   11.42300  21.68900  1.000 71.06194  ? 9    PRO A CB    1 
ATOM   77   C CG    . PRO A 1 29  ? 7.13100   10.76100  21.49700  1.000 70.04215  ? 9    PRO A CG    1 
ATOM   78   C CD    . PRO A 1 29  ? 6.98300   9.98700   20.21700  1.000 70.40610  ? 9    PRO A CD    1 
ATOM   79   N N     . ARG A 1 30  ? 6.55600   13.70000  19.61400  1.000 66.46288  ? 10   ARG A N     1 
ATOM   80   C CA    . ARG A 1 30  ? 6.71200   15.10900  19.27200  1.000 63.97250  ? 10   ARG A CA    1 
ATOM   81   C C     . ARG A 1 30  ? 5.86100   15.47800  18.06900  1.000 60.83972  ? 10   ARG A C     1 
ATOM   82   O O     . ARG A 1 30  ? 5.26400   16.55900  18.02900  1.000 58.64414  ? 10   ARG A O     1 
ATOM   83   C CB    . ARG A 1 30  ? 8.17200   15.42000  18.98100  1.000 64.08701  ? 10   ARG A CB    1 
ATOM   84   C CG    . ARG A 1 30  ? 9.11600   15.09100  20.10400  1.000 69.21443  ? 10   ARG A CG    1 
ATOM   85   C CD    . ARG A 1 30  ? 9.99300   16.29100  20.32700  1.000 70.82486  ? 10   ARG A CD    1 
ATOM   86   N NE    . ARG A 1 30  ? 9.15800   17.48500  20.28000  1.000 71.55784  ? 10   ARG A NE    1 
ATOM   87   C CZ    . ARG A 1 30  ? 9.59900   18.71700  20.49000  1.000 67.68379  ? 10   ARG A CZ    1 
ATOM   88   N NH1   . ARG A 1 30  ? 10.88400  18.92000  20.75400  1.000 64.77083  ? 10   ARG A NH1   1 
ATOM   89   N NH2   . ARG A 1 30  ? 8.75200   19.74100  20.43700  1.000 65.73043  ? 10   ARG A NH2   1 
ATOM   90   N N     . VAL A 1 31  ? 5.79200   14.58600  17.08100  1.000 59.25917  ? 11   VAL A N     1 
ATOM   91   C CA    . VAL A 1 31  ? 5.12500   14.91100  15.82500  1.000 57.55083  ? 11   VAL A CA    1 
ATOM   92   C C     . VAL A 1 31  ? 3.63600   15.12300  16.04600  1.000 58.23717  ? 11   VAL A C     1 
ATOM   93   O O     . VAL A 1 31  ? 3.03500   16.04700  15.47600  1.000 52.34384  ? 11   VAL A O     1 
ATOM   94   C CB    . VAL A 1 31  ? 5.39800   13.81800  14.77600  1.000 56.79438  ? 11   VAL A CB    1 
ATOM   95   C CG1   . VAL A 1 31  ? 4.47500   13.98600  13.57600  1.000 61.08193  ? 11   VAL A CG1   1 
ATOM   96   C CG2   . VAL A 1 31  ? 6.84700   13.87300  14.32800  1.000 56.58501  ? 11   VAL A CG2   1 
ATOM   97   N N     . LYS A 1 32  ? 3.01300   14.27800  16.87900  1.000 56.54761  ? 12   LYS A N     1 
ATOM   98   C CA    . LYS A 1 32  ? 1.59500   14.45400  17.16900  1.000 55.38180  ? 12   LYS A CA    1 
ATOM   99   C C     . LYS A 1 32  ? 1.35200   15.75300  17.91900  1.000 52.76535  ? 12   LYS A C     1 
ATOM   100  O O     . LYS A 1 32  ? 0.38700   16.47200  17.62300  1.000 52.58748  ? 12   LYS A O     1 
ATOM   101  C CB    . LYS A 1 32  ? 1.05600   13.26600  17.96200  1.000 59.38717  ? 12   LYS A CB    1 
ATOM   102  C CG    . LYS A 1 32  ? 1.13200   11.96100  17.19900  1.000 65.63674  ? 12   LYS A CG    1 
ATOM   103  C CD    . LYS A 1 32  ? 0.82600   10.76800  18.08800  1.000 67.53286  ? 12   LYS A CD    1 
ATOM   104  C CE    . LYS A 1 32  ? 0.87700   9.49000   17.26900  1.000 71.05470  ? 12   LYS A CE    1 
ATOM   105  N NZ    . LYS A 1 32  ? 0.03700   9.62100   16.03500  1.000 72.32873  ? 12   LYS A NZ    1 
ATOM   106  N N     . ALA A 1 33  ? 2.22400   16.07400  18.88200  1.000 47.95870  ? 13   ALA A N     1 
ATOM   107  C CA    . ALA A 1 33  ? 2.14300   17.36400  19.56100  1.000 52.67544  ? 13   ALA A CA    1 
ATOM   108  C C     . ALA A 1 33  ? 2.19700   18.51100  18.56100  1.000 53.86290  ? 13   ALA A C     1 
ATOM   109  O O     . ALA A 1 33  ? 1.44100   19.48100  18.67400  1.000 51.03554  ? 13   ALA A O     1 
ATOM   110  C CB    . ALA A 1 33  ? 3.27500   17.49600  20.58300  1.000 49.09079  ? 13   ALA A CB    1 
ATOM   111  N N     . LEU A 1 34  ? 3.06600   18.39700  17.55100  1.000 51.18058  ? 14   LEU A N     1 
ATOM   112  C CA    . LEU A 1 34  ? 3.25700   19.49400  16.61100  1.000 45.87289  ? 14   LEU A CA    1 
ATOM   113  C C     . LEU A 1 34  ? 2.06100   19.64300  15.67600  1.000 47.65990  ? 14   LEU A C     1 
ATOM   114  O O     . LEU A 1 34  ? 1.59300   20.76300  15.43400  1.000 47.17869  ? 14   LEU A O     1 
ATOM   115  C CB    . LEU A 1 34  ? 4.54700   19.27300  15.82300  1.000 51.04550  ? 14   LEU A CB    1 
ATOM   116  C CG    . LEU A 1 34  ? 5.85400   19.36800  16.61600  1.000 48.17258  ? 14   LEU A CG    1 
ATOM   117  C CD1   . LEU A 1 34  ? 7.02800   18.84200  15.78200  1.000 51.89789  ? 14   LEU A CD1   1 
ATOM   118  C CD2   . LEU A 1 34  ? 6.14000   20.80200  17.08300  1.000 48.37712  ? 14   LEU A CD2   1 
ATOM   119  N N     . ALA A 1 35  ? 1.53200   18.53000  15.15400  1.000 49.40029  ? 15   ALA A N     1 
ATOM   120  C CA    . ALA A 1 35  ? 0.38500   18.62700  14.25500  1.000 51.59655  ? 15   ALA A CA    1 
ATOM   121  C C     . ALA A 1 35  ? -0.86000  19.12800  14.98300  1.000 48.68238  ? 15   ALA A C     1 
ATOM   122  O O     . ALA A 1 35  ? -1.74100  19.73300  14.35300  1.000 51.55116  ? 15   ALA A O     1 
ATOM   123  C CB    . ALA A 1 35  ? 0.11400   17.28100  13.59100  1.000 51.86823  ? 15   ALA A CB    1 
ATOM   124  N N     . ALA A 1 36  ? -0.93800  18.91600  16.30300  1.000 45.40580  ? 16   ALA A N     1 
ATOM   125  C CA    . ALA A 1 36  ? -2.05900  19.43200  17.08800  1.000 50.92402  ? 16   ALA A CA    1 
ATOM   126  C C     . ALA A 1 36  ? -2.16700  20.95800  17.03100  1.000 46.98221  ? 16   ALA A C     1 
ATOM   127  O O     . ALA A 1 36  ? -3.25000  21.50800  17.28400  1.000 43.14883  ? 16   ALA A O     1 
ATOM   128  C CB    . ALA A 1 36  ? -1.93100  18.97800  18.54800  1.000 50.80140  ? 16   ALA A CB    1 
ATOM   129  N N     . LEU A 1 37  ? -1.07000  21.65400  16.71300  1.000 45.09796  ? 17   LEU A N     1 
ATOM   130  C CA    . LEU A 1 37  ? -1.09700  23.11000  16.74000  1.000 40.48313  ? 17   LEU A CA    1 
ATOM   131  C C     . LEU A 1 37  ? -1.93600  23.68900  15.61100  1.000 42.98797  ? 17   LEU A C     1 
ATOM   132  O O     . LEU A 1 37  ? -2.20700  24.88900  15.63300  1.000 37.88539  ? 17   LEU A O     1 
ATOM   133  C CB    . LEU A 1 37  ? 0.32700   23.66600  16.67800  1.000 41.89115  ? 17   LEU A CB    1 
ATOM   134  C CG    . LEU A 1 37  ? 1.22200   23.30100  17.86800  1.000 42.69626  ? 17   LEU A CG    1 
ATOM   135  C CD1   . LEU A 1 37  ? 2.64300   23.67500  17.56800  1.000 44.64558  ? 17   LEU A CD1   1 
ATOM   136  C CD2   . LEU A 1 37  ? 0.74700   24.01800  19.13100  1.000 42.41747  ? 17   LEU A CD2   1 
ATOM   137  N N     . LYS A 1 38  ? -2.37800  22.86300  14.65000  1.000 40.46921  ? 18   LYS A N     1 
ATOM   138  C CA    . LYS A 1 38  ? -3.32500  23.32300  13.63900  1.000 44.75909  ? 18   LYS A CA    1 
ATOM   139  C C     . LYS A 1 38  ? -4.70000  23.62700  14.22400  1.000 45.68096  ? 18   LYS A C     1 
ATOM   140  O O     . LYS A 1 38  ? -5.46100  24.37900  13.60500  1.000 46.14870  ? 18   LYS A O     1 
ATOM   141  C CB    . LYS A 1 38  ? -3.45300  22.28600  12.52200  1.000 40.67428  ? 18   LYS A CB    1 
ATOM   142  C CG    . LYS A 1 38  ? -2.13500  22.01500  11.82500  1.000 52.38384  ? 18   LYS A CG    1 
ATOM   143  C CD    . LYS A 1 38  ? -2.29400  21.15700  10.57000  1.000 50.87437  ? 18   LYS A CD    1 
ATOM   144  C CE    . LYS A 1 38  ? -1.67900  19.77300  10.76800  1.000 50.77280  ? 18   LYS A CE    1 
ATOM   145  N NZ    . LYS A 1 38  ? -1.87900  18.92000  9.55500   1.000 53.47825  ? 18   LYS A NZ    1 
ATOM   146  N N     . GLU A 1 39  ? -5.02600  23.08000  15.39900  1.000 44.95358  ? 19   GLU A N     1 
ATOM   147  C CA    . GLU A 1 39  ? -6.29800  23.36900  16.06300  1.000 46.62706  ? 19   GLU A CA    1 
ATOM   148  C C     . GLU A 1 39  ? -6.21900  24.65400  16.88600  1.000 41.66092  ? 19   GLU A C     1 
ATOM   149  O O     . GLU A 1 39  ? -5.33300  24.80300  17.73000  1.000 39.11374  ? 19   GLU A O     1 
ATOM   150  C CB    . GLU A 1 39  ? -6.70200  22.20900  16.97600  1.000 47.57604  ? 19   GLU A CB    1 
ATOM   151  C CG    . GLU A 1 39  ? -6.98500  20.89900  16.23100  1.000 55.00397  ? 19   GLU A CG    1 
ATOM   152  C CD    . GLU A 1 39  ? -8.14300  21.03000  15.23000  1.000 61.14640  ? 19   GLU A CD    1 
ATOM   153  O OE1   . GLU A 1 39  ? -9.17100  21.68900  15.55500  1.000 61.56999  ? 19   GLU A OE1   1 
ATOM   154  O OE2   . GLU A 1 39  ? -8.02200  20.47400  14.11400  1.000 62.94285  ? 19   GLU A OE2   1 
ATOM   155  N N     . ARG A 1 40  ? -7.17400  25.56600  16.66400  1.000 41.94995  ? 20   ARG A N     1 
ATOM   156  C CA    . ARG A 1 40  ? -7.22600  26.78800  17.46000  1.000 44.83296  ? 20   ARG A CA    1 
ATOM   157  C C     . ARG A 1 40  ? -7.20500  26.46900  18.94700  1.000 43.62282  ? 20   ARG A C     1 
ATOM   158  O O     . ARG A 1 40  ? -6.63500  27.22400  19.74800  1.000 39.43861  ? 20   ARG A O     1 
ATOM   159  C CB    . ARG A 1 40  ? -8.48300  27.59400  17.10000  1.000 43.80640  ? 20   ARG A CB    1 
ATOM   160  C CG    . ARG A 1 40  ? -8.55300  28.96600  17.75500  1.000 50.23033  ? 20   ARG A CG    1 
ATOM   161  C CD    . ARG A 1 40  ? -9.92700  29.63700  17.57400  1.000 53.80913  ? 20   ARG A CD    1 
ATOM   162  N NE    . ARG A 1 40  ? -10.99300 28.66300  17.81300  1.000 57.62808  ? 20   ARG A NE    1 
ATOM   163  C CZ    . ARG A 1 40  ? -11.47000 28.33300  19.01600  1.000 60.68331  ? 20   ARG A CZ    1 
ATOM   164  N NH1   . ARG A 1 40  ? -10.98700 28.91400  20.12300  1.000 57.32628  ? 20   ARG A NH1   1 
ATOM   165  N NH2   . ARG A 1 40  ? -12.43800 27.41600  19.10900  1.000 54.62280  ? 20   ARG A NH2   1 
ATOM   166  N N     . LYS A 1 41  ? -7.80700  25.33900  19.32800  1.000 44.61762  ? 21   LYS A N     1 
ATOM   167  C CA    . LYS A 1 41  ? -7.94200  25.00300  20.73800  1.000 44.48723  ? 21   LYS A CA    1 
ATOM   168  C C     . LYS A 1 41  ? -6.59600  24.62900  21.34500  1.000 44.46153  ? 21   LYS A C     1 
ATOM   169  O O     . LYS A 1 41  ? -6.32400  24.93000  22.51500  1.000 40.58588  ? 21   LYS A O     1 
ATOM   170  C CB    . LYS A 1 41  ? -8.94800  23.86400  20.88600  1.000 45.04670  ? 21   LYS A CB    1 
ATOM   171  C CG    . LYS A 1 41  ? -9.25200  23.49700  22.31200  1.000 53.35752  ? 21   LYS A CG    1 
ATOM   172  C CD    . LYS A 1 41  ? -10.75300 23.64200  22.60800  1.000 53.01335  ? 21   LYS A CD    1 
ATOM   173  C CE    . LYS A 1 41  ? -11.06600 23.28000  24.06700  1.000 56.47335  ? 21   LYS A CE    1 
ATOM   174  N NZ    . LYS A 1 41  ? -10.42900 24.21700  25.04400  1.000 58.03422  ? 21   LYS A NZ    1 
ATOM   175  N N     . GLU A 1 42  ? -5.75300  23.94700  20.57500  1.000 39.18828  ? 22   GLU A N     1 
ATOM   176  C CA    . GLU A 1 42  ? -4.43300  23.57700  21.07800  1.000 43.72489  ? 22   GLU A CA    1 
ATOM   177  C C     . GLU A 1 42  ? -3.51500  24.79500  21.15200  1.000 43.26366  ? 22   GLU A C     1 
ATOM   178  O O     . GLU A 1 42  ? -2.66900  24.89700  22.05400  1.000 44.44234  ? 22   GLU A O     1 
ATOM   179  C CB    . GLU A 1 42  ? -3.84300  22.47800  20.18400  1.000 41.58367  ? 22   GLU A CB    1 
ATOM   180  C CG    . GLU A 1 42  ? -2.41800  22.04300  20.50500  1.000 42.92026  ? 22   GLU A CG    1 
ATOM   181  C CD    . GLU A 1 42  ? -2.29800  21.29100  21.82800  1.000 47.98653  ? 22   GLU A CD    1 
ATOM   182  O OE1   . GLU A 1 42  ? -1.18100  20.78500  22.10400  1.000 47.50689  ? 22   GLU A OE1   1 
ATOM   183  O OE2   . GLU A 1 42  ? -3.30200  21.20800  22.58500  1.000 44.71723  ? 22   GLU A OE2   1 
ATOM   184  N N     . ARG A 1 43  ? -3.66000  25.72600  20.20400  1.000 39.86684  ? 23   ARG A N     1 
ATOM   185  C CA    . ARG A 1 43  ? -2.89400  26.96700  20.26800  1.000 36.20750  ? 23   ARG A CA    1 
ATOM   186  C C     . ARG A 1 43  ? -3.25200  27.75000  21.52900  1.000 43.95994  ? 23   ARG A C     1 
ATOM   187  O O     . ARG A 1 43  ? -2.37300  28.31000  22.19700  1.000 43.15974  ? 23   ARG A O     1 
ATOM   188  C CB    . ARG A 1 43  ? -3.15100  27.80600  19.00600  1.000 38.24388  ? 23   ARG A CB    1 
ATOM   189  C CG    . ARG A 1 43  ? -2.68800  27.13300  17.69200  1.000 33.35965  ? 23   ARG A CG    1 
ATOM   190  C CD    . ARG A 1 43  ? -2.54100  28.13300  16.55900  1.000 38.42339  ? 23   ARG A CD    1 
ATOM   191  N NE    . ARG A 1 43  ? -3.80100  28.78200  16.14100  1.000 37.61229  ? 23   ARG A NE    1 
ATOM   192  C CZ    . ARG A 1 43  ? -4.68100  28.23500  15.30100  1.000 39.64309  ? 23   ARG A CZ    1 
ATOM   193  N NH1   . ARG A 1 43  ? -4.47400  27.01700  14.79900  1.000 36.53144  ? 23   ARG A NH1   1 
ATOM   194  N NH2   . ARG A 1 43  ? -5.78000  28.90900  14.97000  1.000 38.30767  ? 23   ARG A NH2   1 
ATOM   195  N N     . GLU A 1 44  ? -4.53800  27.79100  21.88200  1.000 39.65977  ? 24   GLU A N     1 
ATOM   196  C CA    . GLU A 1 44  ? -4.91300  28.45900  23.12200  1.000 44.56300  ? 24   GLU A CA    1 
ATOM   197  C C     . GLU A 1 44  ? -4.36700  27.70700  24.33000  1.000 42.95471  ? 24   GLU A C     1 
ATOM   198  O O     . GLU A 1 44  ? -3.85700  28.32300  25.27000  1.000 44.05846  ? 24   GLU A O     1 
ATOM   199  C CB    . GLU A 1 44  ? -6.43600  28.59600  23.22400  1.000 48.02284  ? 24   GLU A CB    1 
ATOM   200  C CG    . GLU A 1 44  ? -6.99600  29.83100  22.58400  1.000 49.84774  ? 24   GLU A CG    1 
ATOM   201  C CD    . GLU A 1 44  ? -8.40300  30.17300  23.08300  1.000 60.79615  ? 24   GLU A CD    1 
ATOM   202  O OE1   . GLU A 1 44  ? -9.19800  29.23200  23.37200  1.000 59.85266  ? 24   GLU A OE1   1 
ATOM   203  O OE2   . GLU A 1 44  ? -8.70000  31.39600  23.18700  1.000 58.86030  ? 24   GLU A OE2   1 
ATOM   204  N N     . ARG A 1 45  ? -4.46700  26.37600  24.32400  1.000 43.69301  ? 25   ARG A N     1 
ATOM   205  C CA    . ARG A 1 45  ? -4.01200  25.60200  25.47400  1.000 47.07840  ? 25   ARG A CA    1 
ATOM   206  C C     . ARG A 1 45  ? -2.51600  25.78900  25.72100  1.000 48.46603  ? 25   ARG A C     1 
ATOM   207  O O     . ARG A 1 45  ? -2.07300  25.88100  26.87200  1.000 47.85146  ? 25   ARG A O     1 
ATOM   208  C CB    . ARG A 1 45  ? -4.33700  24.11800  25.26100  1.000 51.77315  ? 25   ARG A CB    1 
ATOM   209  C CG    . ARG A 1 45  ? -3.93600  23.23300  26.44700  1.000 49.64569  ? 25   ARG A CG    1 
ATOM   210  C CD    . ARG A 1 45  ? -4.06600  21.72400  26.14000  1.000 52.58007  ? 25   ARG A CD    1 
ATOM   211  N NE    . ARG A 1 45  ? -3.06300  21.22100  25.20100  1.000 50.35669  ? 25   ARG A NE    1 
ATOM   212  C CZ    . ARG A 1 45  ? -1.84000  20.81600  25.55000  1.000 52.44089  ? 25   ARG A CZ    1 
ATOM   213  N NH1   . ARG A 1 45  ? -1.46100  20.86000  26.82100  1.000 52.45624  ? 25   ARG A NH1   1 
ATOM   214  N NH2   . ARG A 1 45  ? -0.99100  20.36600  24.63300  1.000 47.71346  ? 25   ARG A NH2   1 
ATOM   215  N N     . THR A 1 46  ? -1.72300  25.84500  24.65300  1.000 47.73966  ? 26   THR A N     1 
ATOM   216  C CA    . THR A 1 46  ? -0.26700  25.86100  24.75100  1.000 44.89936  ? 26   THR A CA    1 
ATOM   217  C C     . THR A 1 46  ? 0.34400   27.25500  24.70200  1.000 44.94331  ? 26   THR A C     1 
ATOM   218  O O     . THR A 1 46  ? 1.47300   27.44100  25.17900  1.000 38.64822  ? 26   THR A O     1 
ATOM   219  C CB    . THR A 1 46  ? 0.33900   25.05300  23.60100  1.000 44.76539  ? 26   THR A CB    1 
ATOM   220  O OG1   . THR A 1 46  ? -0.01500  25.69100  22.37400  1.000 46.26449  ? 26   THR A OG1   1 
ATOM   221  C CG2   . THR A 1 46  ? -0.19600  23.63200  23.57600  1.000 46.16023  ? 26   THR A CG2   1 
ATOM   222  N N     . GLY A 1 47  ? -0.30700  28.19200  24.02200  1.000 41.42211  ? 27   GLY A N     1 
ATOM   223  C CA    . GLY A 1 47  ? 0.30700   29.52000  23.84200  1.000 41.94390  ? 27   GLY A CA    1 
ATOM   224  C C     . GLY A 1 47  ? 1.29400   29.53600  22.68400  1.000 43.77189  ? 27   GLY A C     1 
ATOM   225  O O     . GLY A 1 47  ? 1.96900   30.55800  22.49300  1.000 39.58079  ? 27   GLY A O     1 
ATOM   226  N N     . ARG A 1 48  ? 1.37400   28.43100  21.94000  1.000 39.69134  ? 28   ARG A N     1 
ATOM   227  C CA    . ARG A 1 48  ? 2.30500   28.34700  20.78900  1.000 38.48761  ? 28   ARG A CA    1 
ATOM   228  C C     . ARG A 1 48  ? 1.53900   28.11700  19.48300  1.000 39.99289  ? 28   ARG A C     1 
ATOM   229  O O     . ARG A 1 48  ? 0.35500   27.76700  19.53300  1.000 39.91938  ? 28   ARG A O     1 
ATOM   230  C CB    . ARG A 1 48  ? 3.31900   27.21900  20.97300  1.000 40.43916  ? 28   ARG A CB    1 
ATOM   231  C CG    . ARG A 1 48  ? 4.18900   27.36300  22.21200  1.000 46.75276  ? 28   ARG A CG    1 
ATOM   232  C CD    . ARG A 1 48  ? 5.10900   26.16900  22.37200  1.000 51.14684  ? 28   ARG A CD    1 
ATOM   233  N NE    . ARG A 1 48  ? 4.36000   24.91600  22.50500  1.000 56.76222  ? 28   ARG A NE    1 
ATOM   234  C CZ    . ARG A 1 48  ? 3.99400   24.37400  23.66000  1.000 59.04324  ? 28   ARG A CZ    1 
ATOM   235  N NH1   . ARG A 1 48  ? 4.23900   24.99900  24.79600  1.000 58.68021  ? 28   ARG A NH1   1 
ATOM   236  N NH2   . ARG A 1 48  ? 3.38100   23.20700  23.67800  1.000 60.36925  ? 28   ARG A NH2   1 
ATOM   237  N N     . PHE A 1 49  ? 2.22500   28.30400  18.36300  1.000 34.56504  ? 29   PHE A N     1 
ATOM   238  C CA    . PHE A 1 49  ? 1.58800   28.10300  17.04200  1.000 35.11625  ? 29   PHE A CA    1 
ATOM   239  C C     . PHE A 1 49  ? 2.63600   27.72700  16.01200  1.000 37.79010  ? 29   PHE A C     1 
ATOM   240  O O     . PHE A 1 49  ? 3.82900   27.97100  16.22800  1.000 34.52221  ? 29   PHE A O     1 
ATOM   241  C CB    . PHE A 1 49  ? 0.78300   29.32100  16.59200  1.000 34.23300  ? 29   PHE A CB    1 
ATOM   242  C CG    . PHE A 1 49  ? 1.55400   30.55400  16.15300  1.000 33.11353  ? 29   PHE A CG    1 
ATOM   243  C CD1   . PHE A 1 49  ? 2.42000   31.20500  17.02100  1.000 34.42925  ? 29   PHE A CD1   1 
ATOM   244  C CD2   . PHE A 1 49  ? 1.37500   31.07800  14.88200  1.000 36.17500  ? 29   PHE A CD2   1 
ATOM   245  C CE1   . PHE A 1 49  ? 3.09700   32.34000  16.61900  1.000 33.47762  ? 29   PHE A CE1   1 
ATOM   246  C CE2   . PHE A 1 49  ? 2.05600   32.21400  14.48800  1.000 35.24690  ? 29   PHE A CE2   1 
ATOM   247  C CZ    . PHE A 1 49  ? 2.91500   32.83900  15.35500  1.000 34.02750  ? 29   PHE A CZ    1 
ATOM   248  N N     . LEU A 1 50  ? 2.17200   27.17000  14.90300  1.000 36.13267  ? 30   LEU A N     1 
ATOM   249  C CA    . LEU A 1 50  ? 3.05700   26.68100  13.85000  1.000 36.19338  ? 30   LEU A CA    1 
ATOM   250  C C     . LEU A 1 50  ? 3.09400   27.68500  12.71800  1.000 38.56447  ? 30   LEU A C     1 
ATOM   251  O O     . LEU A 1 50  ? 2.04700   28.19300  12.29000  1.000 37.61155  ? 30   LEU A O     1 
ATOM   252  C CB    . LEU A 1 50  ? 2.59600   25.31700  13.32000  1.000 37.47544  ? 30   LEU A CB    1 
ATOM   253  C CG    . LEU A 1 50  ? 3.60800   24.49300  12.50000  1.000 47.87873  ? 30   LEU A CG    1 
ATOM   254  C CD1   . LEU A 1 50  ? 4.67900   23.87700  13.40500  1.000 42.07871  ? 30   LEU A CD1   1 
ATOM   255  C CD2   . LEU A 1 50  ? 2.90700   23.40000  11.67800  1.000 46.69146  ? 30   LEU A CD2   1 
ATOM   256  N N     . VAL A 1 51  ? 4.29700   27.97200  12.22600  1.000 35.88075  ? 31   VAL A N     1 
ATOM   257  C CA    . VAL A 1 51  ? 4.47700   28.85700  11.08800  1.000 33.43334  ? 31   VAL A CA    1 
ATOM   258  C C     . VAL A 1 51  ? 5.16100   28.04600  10.00000  1.000 35.91910  ? 31   VAL A C     1 
ATOM   259  O O     . VAL A 1 51  ? 6.30400   27.60500  10.17600  1.000 33.28848  ? 31   VAL A O     1 
ATOM   260  C CB    . VAL A 1 51  ? 5.30900   30.09700  11.44800  1.000 33.88984  ? 31   VAL A CB    1 
ATOM   261  C CG1   . VAL A 1 51  ? 5.58200   30.86600  10.20100  1.000 29.28869  ? 31   VAL A CG1   1 
ATOM   262  C CG2   . VAL A 1 51  ? 4.56200   30.93300  12.46100  1.000 34.29161  ? 31   VAL A CG2   1 
ATOM   263  N N     . GLU A 1 52  ? 4.48000   27.85600  8.87600   1.000 34.35248  ? 32   GLU A N     1 
ATOM   264  C CA    . GLU A 1 52  ? 4.91800   26.90100  7.86500   1.000 35.29697  ? 32   GLU A CA    1 
ATOM   265  C C     . GLU A 1 52  ? 5.41200   27.63300  6.63200   1.000 31.49853  ? 32   GLU A C     1 
ATOM   266  O O     . GLU A 1 52  ? 4.71700   28.51100  6.11300   1.000 34.88972  ? 32   GLU A O     1 
ATOM   267  C CB    . GLU A 1 52  ? 3.77700   25.94700  7.47800   1.000 38.82048  ? 32   GLU A CB    1 
ATOM   268  C CG    . GLU A 1 52  ? 4.14900   25.07500  6.28500   1.000 39.59474  ? 32   GLU A CG    1 
ATOM   269  C CD    . GLU A 1 52  ? 3.25500   23.86100  6.10700   1.000 45.22946  ? 32   GLU A CD    1 
ATOM   270  O OE1   . GLU A 1 52  ? 2.19100   23.80000  6.76900   1.000 43.93224  ? 32   GLU A OE1   1 
ATOM   271  O OE2   . GLU A 1 52  ? 3.62800   22.97500  5.30100   1.000 43.29069  ? 32   GLU A OE2   1 
ATOM   272  N N     . GLY A 1 53  ? 6.60300   27.28800  6.17300   1.000 33.52540  ? 33   GLY A N     1 
ATOM   273  C CA    . GLY A 1 53  ? 7.12200   27.89200  4.95000   1.000 33.21920  ? 33   GLY A CA    1 
ATOM   274  C C     . GLY A 1 53  ? 8.25500   28.87500  5.19600   1.000 36.69249  ? 33   GLY A C     1 
ATOM   275  O O     . GLY A 1 53  ? 8.19200   29.71800  6.10500   1.000 34.31185  ? 33   GLY A O     1 
ATOM   276  N N     . ARG A 1 54  ? 9.28900   28.80200  4.34800   1.000 36.79243  ? 34   ARG A N     1 
ATOM   277  C CA    . ARG A 1 54  ? 10.50800  29.57500  4.61200   1.000 37.42981  ? 34   ARG A CA    1 
ATOM   278  C C     . ARG A 1 54  ? 10.21200  31.07100  4.64900   1.000 36.54485  ? 34   ARG A C     1 
ATOM   279  O O     . ARG A 1 54  ? 10.65100  31.78500  5.56100   1.000 33.60810  ? 34   ARG A O     1 
ATOM   280  C CB    . ARG A 1 54  ? 11.57600  29.25400  3.55600   1.000 38.98010  ? 34   ARG A CB    1 
ATOM   281  C CG    . ARG A 1 54  ? 12.85900  30.03200  3.72700   1.000 36.82704  ? 34   ARG A CG    1 
ATOM   282  C CD    . ARG A 1 54  ? 13.87700  29.74000  2.62900   1.000 39.24527  ? 34   ARG A CD    1 
ATOM   283  N NE    . ARG A 1 54  ? 14.37200  28.37600  2.71600   1.000 38.11292  ? 34   ARG A NE    1 
ATOM   284  C CZ    . ARG A 1 54  ? 14.06000  27.40000  1.86600   1.000 43.00987  ? 34   ARG A CZ    1 
ATOM   285  N NH1   . ARG A 1 54  ? 13.25300  27.63600  0.84200   1.000 42.79630  ? 34   ARG A NH1   1 
ATOM   286  N NH2   . ARG A 1 54  ? 14.55000  26.17900  2.05700   1.000 41.50281  ? 34   ARG A NH2   1 
ATOM   287  N N     . ARG A 1 55  ? 9.44500   31.57000  3.67900   1.000 34.52028  ? 35   ARG A N     1 
ATOM   288  C CA    . ARG A 1 55  ? 9.13100   32.99500  3.69700   1.000 34.63861  ? 35   ARG A CA    1 
ATOM   289  C C     . ARG A 1 55  ? 8.39700   33.36900  4.97700   1.000 36.26789  ? 35   ARG A C     1 
ATOM   290  O O     . ARG A 1 55  ? 8.73000   34.36700  5.62800   1.000 34.80552  ? 35   ARG A O     1 
ATOM   291  C CB    . ARG A 1 55  ? 8.31100   33.36900  2.47400   1.000 37.47944  ? 35   ARG A CB    1 
ATOM   292  C CG    . ARG A 1 55  ? 7.90400   34.85500  2.42700   1.000 42.66391  ? 35   ARG A CG    1 
ATOM   293  C CD    . ARG A 1 55  ? 9.13400   35.80200  2.64800   1.000 47.00178  ? 35   ARG A CD    1 
ATOM   294  N NE    . ARG A 1 55  ? 8.80700   37.21200  2.37200   1.000 50.42194  ? 35   ARG A NE    1 
ATOM   295  C CZ    . ARG A 1 55  ? 9.66000   38.23200  2.48600   1.000 55.88734  ? 35   ARG A CZ    1 
ATOM   296  N NH1   . ARG A 1 55  ? 10.91700  38.02100  2.89500   1.000 55.96710  ? 35   ARG A NH1   1 
ATOM   297  N NH2   . ARG A 1 55  ? 9.25800   39.47300  2.20500   1.000 53.93396  ? 35   ARG A NH2   1 
ATOM   298  N N     . GLU A 1 56  ? 7.43000   32.54800  5.38500   1.000 34.18897  ? 36   GLU A N     1 
ATOM   299  C CA    . GLU A 1 56  ? 6.61300   32.90600  6.54100   1.000 30.89357  ? 36   GLU A CA    1 
ATOM   300  C C     . GLU A 1 56  ? 7.43000   32.84100  7.82600   1.000 31.15912  ? 36   GLU A C     1 
ATOM   301  O O     . GLU A 1 56  ? 7.27500   33.69100  8.71100   1.000 32.55682  ? 36   GLU A O     1 
ATOM   302  C CB    . GLU A 1 56  ? 5.37300   31.99700  6.61100   1.000 29.40418  ? 36   GLU A CB    1 
ATOM   303  C CG    . GLU A 1 56  ? 4.29800   32.29100  5.53600   1.000 34.85009  ? 36   GLU A CG    1 
ATOM   304  C CD    . GLU A 1 56  ? 4.65200   31.77400  4.14500   1.000 36.66078  ? 36   GLU A CD    1 
ATOM   305  O OE1   . GLU A 1 56  ? 5.50500   30.88300  4.04300   1.000 36.35405  ? 36   GLU A OE1   1 
ATOM   306  O OE2   . GLU A 1 56  ? 4.10400   32.28400  3.14700   1.000 46.48862  ? 36   GLU A OE2   1 
ATOM   307  N N     . VAL A 1 57  ? 8.34100   31.87200  7.92500   1.000 33.37351  ? 37   VAL A N     1 
ATOM   308  C CA    . VAL A 1 57  ? 9.24900   31.81300  9.06900   1.000 31.08693  ? 37   VAL A CA    1 
ATOM   309  C C     . VAL A 1 57  ? 10.16500  33.02800  9.10100   1.000 31.58732  ? 37   VAL A C     1 
ATOM   310  O O     . VAL A 1 57  ? 10.41900  33.59800  10.17400  1.000 30.53256  ? 37   VAL A O     1 
ATOM   311  C CB    . VAL A 1 57  ? 10.05100  30.50500  9.02700   1.000 33.81588  ? 37   VAL A CB    1 
ATOM   312  C CG1   . VAL A 1 57  ? 11.21100  30.55300  10.05900  1.000 31.50910  ? 37   VAL A CG1   1 
ATOM   313  C CG2   . VAL A 1 57  ? 9.09500   29.34000  9.30200   1.000 30.95109  ? 37   VAL A CG2   1 
ATOM   314  N N     . GLU A 1 58  ? 10.68500  33.43300  7.93100   1.000 28.09518  ? 38   GLU A N     1 
ATOM   315  C CA    . GLU A 1 58  ? 11.47100  34.66500  7.84000   1.000 33.60414  ? 38   GLU A CA    1 
ATOM   316  C C     . GLU A 1 58  ? 10.69500  35.84600  8.40400   1.000 34.22834  ? 38   GLU A C     1 
ATOM   317  O O     . GLU A 1 58  ? 11.23200  36.64700  9.18400   1.000 33.73572  ? 38   GLU A O     1 
ATOM   318  C CB    . GLU A 1 58  ? 11.86800  34.93500  6.38600   1.000 33.27055  ? 38   GLU A CB    1 
ATOM   319  C CG    . GLU A 1 58  ? 12.88800  33.94100  5.82200   1.000 37.42016  ? 38   GLU A CG    1 
ATOM   320  C CD    . GLU A 1 58  ? 13.03500  34.03200  4.31700   1.000 37.18063  ? 38   GLU A CD    1 
ATOM   321  O OE1   . GLU A 1 58  ? 13.74400  33.17800  3.71100   1.000 34.91792  ? 38   GLU A OE1   1 
ATOM   322  O OE2   . GLU A 1 58  ? 12.42700  34.95300  3.74100   1.000 37.73195  ? 38   GLU A OE2   1 
ATOM   323  N N     . ARG A 1 59  ? 9.41600   35.96900  8.01300   1.000 32.51390  ? 39   ARG A N     1 
ATOM   324  C CA    . ARG A 1 59  ? 8.63500   37.13500  8.41100   1.000 32.19685  ? 39   ARG A CA    1 
ATOM   325  C C     . ARG A 1 59  ? 8.34300   37.11900  9.89800   1.000 33.45596  ? 39   ARG A C     1 
ATOM   326  O O     . ARG A 1 59  ? 8.39500   38.17200  10.54200  1.000 32.18349  ? 39   ARG A O     1 
ATOM   327  C CB    . ARG A 1 59  ? 7.32200   37.22300  7.61600   1.000 34.01217  ? 39   ARG A CB    1 
ATOM   328  C CG    . ARG A 1 59  ? 7.47400   37.29100  6.12500   1.000 34.30626  ? 39   ARG A CG    1 
ATOM   329  C CD    . ARG A 1 59  ? 8.20300   38.54200  5.71800   1.000 40.15559  ? 39   ARG A CD    1 
ATOM   330  N NE    . ARG A 1 59  ? 7.59500   39.74000  6.30600   1.000 49.07123  ? 39   ARG A NE    1 
ATOM   331  C CZ    . ARG A 1 59  ? 6.44700   40.27000  5.88200   1.000 49.64882  ? 39   ARG A CZ    1 
ATOM   332  N NH1   . ARG A 1 59  ? 5.78100   39.69400  4.87600   1.000 44.68652  ? 39   ARG A NH1   1 
ATOM   333  N NH2   . ARG A 1 59  ? 5.95600   41.37000  6.45800   1.000 45.21206  ? 39   ARG A NH2   1 
ATOM   334  N N     . ALA A 1 60  ? 7.99000   35.94600  10.45700  1.000 31.92033  ? 40   ALA A N     1 
ATOM   335  C CA    . ALA A 1 60  ? 7.78100   35.86400  11.89900  1.000 31.60567  ? 40   ALA A CA    1 
ATOM   336  C C     . ALA A 1 60  ? 9.04700   36.25100  12.66600  1.000 34.61051  ? 40   ALA A C     1 
ATOM   337  O O     . ALA A 1 60  ? 8.97600   36.95700  13.68300  1.000 33.83825  ? 40   ALA A O     1 
ATOM   338  C CB    . ALA A 1 60  ? 7.33700   34.46500  12.29700  1.000 30.56539  ? 40   ALA A CB    1 
ATOM   339  N N     . LEU A 1 61  ? 10.21500  35.78900  12.19800  1.000 31.45920  ? 41   LEU A N     1 
ATOM   340  C CA    . LEU A 1 61  ? 11.47400  36.16800  12.84500  1.000 35.25444  ? 41   LEU A CA    1 
ATOM   341  C C     . LEU A 1 61  ? 11.71900  37.66500  12.74500  1.000 33.06097  ? 41   LEU A C     1 
ATOM   342  O O     . LEU A 1 61  ? 12.04000  38.32900  13.74300  1.000 36.48979  ? 41   LEU A O     1 
ATOM   343  C CB    . LEU A 1 61  ? 12.64700  35.41400  12.21500  1.000 32.57274  ? 41   LEU A CB    1 
ATOM   344  C CG    . LEU A 1 61  ? 12.80200  33.94300  12.57600  1.000 32.33344  ? 41   LEU A CG    1 
ATOM   345  C CD1   . LEU A 1 61  ? 13.87400  33.33600  11.69600  1.000 33.09233  ? 41   LEU A CD1   1 
ATOM   346  C CD2   . LEU A 1 61  ? 13.11300  33.77200  14.08200  1.000 38.15191  ? 41   LEU A CD2   1 
ATOM   347  N N     . GLU A 1 62  ? 11.62900  38.20200  11.53100  1.000 31.25533  ? 42   GLU A N     1 
ATOM   348  C CA    . GLU A 1 62  ? 11.83100  39.62700  11.31900  1.000 35.66113  ? 42   GLU A CA    1 
ATOM   349  C C     . GLU A 1 62  ? 10.86500  40.47000  12.13500  1.000 39.39681  ? 42   GLU A C     1 
ATOM   350  O O     . GLU A 1 62  ? 11.19800  41.60300  12.49800  1.000 35.44838  ? 42   GLU A O     1 
ATOM   351  C CB    . GLU A 1 62  ? 11.70900  39.94500  9.83100   1.000 31.38637  ? 42   GLU A CB    1 
ATOM   352  C CG    . GLU A 1 62  ? 12.90300  39.44300  9.06300   1.000 36.41075  ? 42   GLU A CG    1 
ATOM   353  C CD    . GLU A 1 62  ? 12.66100  39.28800  7.57000   1.000 39.35312  ? 42   GLU A CD    1 
ATOM   354  O OE1   . GLU A 1 62  ? 11.59000  39.67500  7.09100   1.000 41.11826  ? 42   GLU A OE1   1 
ATOM   355  O OE2   . GLU A 1 62  ? 13.55500  38.76700  6.86000   1.000 42.15153  ? 42   GLU A OE2   1 
ATOM   356  N N     . ALA A 1 63  ? 9.66400   39.95300  12.42500  1.000 33.75486  ? 43   ALA A N     1 
ATOM   357  C CA    . ALA A 1 63  ? 8.70800   40.72800  13.19600  1.000 32.36754  ? 43   ALA A CA    1 
ATOM   358  C C     . ALA A 1 63  ? 9.00400   40.68000  14.68600  1.000 37.46089  ? 43   ALA A C     1 
ATOM   359  O O     . ALA A 1 63  ? 8.34200   41.37100  15.45400  1.000 36.04869  ? 43   ALA A O     1 
ATOM   360  C CB    . ALA A 1 63  ? 7.28000   40.23400  12.90800  1.000 35.28961  ? 43   ALA A CB    1 
ATOM   361  N N     . GLY A 1 64  ? 9.99300   39.90200  15.11000  1.000 33.85462  ? 44   GLY A N     1 
ATOM   362  C CA    . GLY A 1 64  ? 10.36800  39.84100  16.50200  1.000 36.76138  ? 44   GLY A CA    1 
ATOM   363  C C     . GLY A 1 64  ? 9.71000   38.74800  17.29900  1.000 37.88373  ? 44   GLY A C     1 
ATOM   364  O O     . GLY A 1 64  ? 9.78600   38.77700  18.54200  1.000 36.12770  ? 44   GLY A O     1 
ATOM   365  N N     . LEU A 1 65  ? 9.09000   37.79500  16.60900  1.000 36.14147  ? 45   LEU A N     1 
ATOM   366  C CA    . LEU A 1 65  ? 8.39800   36.69500  17.31700  1.000 34.11024  ? 45   LEU A CA    1 
ATOM   367  C C     . LEU A 1 65  ? 9.43500   35.70900  17.87500  1.000 35.97533  ? 45   LEU A C     1 
ATOM   368  O O     . LEU A 1 65  ? 10.48300  35.55500  17.25100  1.000 36.61243  ? 45   LEU A O     1 
ATOM   369  C CB    . LEU A 1 65  ? 7.38400   36.03000  16.39300  1.000 34.66676  ? 45   LEU A CB    1 
ATOM   370  C CG    . LEU A 1 65  ? 5.99000   36.66100  16.36400  1.000 37.16326  ? 45   LEU A CG    1 
ATOM   371  C CD1   . LEU A 1 65  ? 5.99000   37.97200  15.61100  1.000 39.31568  ? 45   LEU A CD1   1 
ATOM   372  C CD2   . LEU A 1 65  ? 4.99300   35.70400  15.75500  1.000 32.03745  ? 45   LEU A CD2   1 
ATOM   373  N N     . SER A 1 66  ? 9.12900   35.07300  19.00600  1.000 38.28731  ? 46   SER A N     1 
ATOM   374  C CA    . SER A 1 66  ? 10.07400  34.13400  19.66000  1.000 36.85949  ? 46   SER A CA    1 
ATOM   375  C C     . SER A 1 66  ? 9.96700   32.73000  19.05900  1.000 36.34639  ? 46   SER A C     1 
ATOM   376  O O     . SER A 1 66  ? 8.92300   32.10000  19.21900  1.000 34.66557  ? 46   SER A O     1 
ATOM   377  C CB    . SER A 1 66  ? 9.89500   34.09500  21.16300  1.000 40.04153  ? 46   SER A CB    1 
ATOM   378  O OG    . SER A 1 66  ? 9.95600   35.39800  21.72200  1.000 54.47580  ? 46   SER A OG    1 
ATOM   379  N N     . LEU A 1 67  ? 11.03100  32.27000  18.41900  1.000 37.33908  ? 47   LEU A N     1 
ATOM   380  C CA    . LEU A 1 67  ? 11.08200  30.93000  17.85100  1.000 36.13472  ? 47   LEU A CA    1 
ATOM   381  C C     . LEU A 1 67  ? 11.49700  29.93200  18.92500  1.000 41.68819  ? 47   LEU A C     1 
ATOM   382  O O     . LEU A 1 67  ? 12.56400  30.08300  19.52000  1.000 41.94249  ? 47   LEU A O     1 
ATOM   383  C CB    . LEU A 1 67  ? 12.06800  30.91000  16.68700  1.000 36.99479  ? 47   LEU A CB    1 
ATOM   384  C CG    . LEU A 1 67  ? 12.32700  29.55400  16.03900  1.000 41.29801  ? 47   LEU A CG    1 
ATOM   385  C CD1   . LEU A 1 67  ? 11.07500  28.97100  15.33700  1.000 35.42466  ? 47   LEU A CD1   1 
ATOM   386  C CD2   . LEU A 1 67  ? 13.47300  29.72000  15.05500  1.000 39.82607  ? 47   LEU A CD2   1 
ATOM   387  N N     . GLU A 1 68  ? 10.70500  28.89500  19.15000  1.000 37.76015  ? 48   GLU A N     1 
ATOM   388  C CA    . GLU A 1 68  ? 11.03800  27.90400  20.19500  1.000 39.88880  ? 48   GLU A CA    1 
ATOM   389  C C     . GLU A 1 68  ? 11.63900  26.65600  19.54700  1.000 40.29935  ? 48   GLU A C     1 
ATOM   390  O O     . GLU A 1 68  ? 12.56600  26.08600  20.12300  1.000 37.92642  ? 48   GLU A O     1 
ATOM   391  C CB    . GLU A 1 68  ? 9.79600   27.52500  20.99300  1.000 42.57730  ? 48   GLU A CB    1 
ATOM   392  C CG    . GLU A 1 68  ? 9.07300   28.72200  21.60000  1.000 50.12431  ? 48   GLU A CG    1 
ATOM   393  C CD    . GLU A 1 68  ? 9.76900   29.24600  22.83900  1.000 58.58419  ? 48   GLU A CD    1 
ATOM   394  O OE1   . GLU A 1 68  ? 10.33400  28.42500  23.58800  1.000 66.30650  ? 48   GLU A OE1   1 
ATOM   395  O OE2   . GLU A 1 68  ? 9.75300   30.47300  23.05300  1.000 63.24576  ? 48   GLU A OE2   1 
ATOM   396  N N     . THR A 1 69  ? 11.14500  26.28800  18.37300  1.000 37.29919  ? 49   THR A N     1 
ATOM   397  C CA    . THR A 1 69  ? 11.56900  25.04700  17.73900  1.000 39.66285  ? 49   THR A CA    1 
ATOM   398  C C     . THR A 1 69  ? 11.52400  25.25100  16.23600  1.000 38.16818  ? 49   THR A C     1 
ATOM   399  O O     . THR A 1 69  ? 10.47700  25.63700  15.69400  1.000 38.25588  ? 49   THR A O     1 
ATOM   400  C CB    . THR A 1 69  ? 10.64800  23.88600  18.14900  1.000 41.69428  ? 49   THR A CB    1 
ATOM   401  O OG1   . THR A 1 69  ? 10.67800  23.73300  19.57700  1.000 48.99168  ? 49   THR A OG1   1 
ATOM   402  C CG2   . THR A 1 69  ? 11.04800  22.61400  17.48100  1.000 39.37404  ? 49   THR A CG2   1 
ATOM   403  N N     . LEU A 1 70  ? 12.65100  25.01100  15.57500  1.000 37.39215  ? 50   LEU A N     1 
ATOM   404  C CA    . LEU A 1 70  ? 12.75400  25.06100  14.12500  1.000 35.97658  ? 50   LEU A CA    1 
ATOM   405  C C     . LEU A 1 70  ? 12.66300  23.63300  13.59400  1.000 43.06767  ? 50   LEU A C     1 
ATOM   406  O O     . LEU A 1 70  ? 13.32300  22.73400  14.12200  1.000 39.94211  ? 50   LEU A O     1 
ATOM   407  C CB    . LEU A 1 70  ? 14.07700  25.70900  13.69400  1.000 36.29267  ? 50   LEU A CB    1 
ATOM   408  C CG    . LEU A 1 70  ? 14.31400  25.85400  12.18800  1.000 35.33852  ? 50   LEU A CG    1 
ATOM   409  C CD1   . LEU A 1 70  ? 13.31100  26.83700  11.56100  1.000 36.08038  ? 50   LEU A CD1   1 
ATOM   410  C CD2   . LEU A 1 70  ? 15.77600  26.28700  11.90000  1.000 37.09623  ? 50   LEU A CD2   1 
ATOM   411  N N     . LEU A 1 71  ? 11.81300  23.42100  12.59500  1.000 37.34816  ? 51   LEU A N     1 
ATOM   412  C CA    . LEU A 1 71  ? 11.65600  22.12600  11.94700  1.000 36.13254  ? 51   LEU A CA    1 
ATOM   413  C C     . LEU A 1 71  ? 12.25400  22.24000  10.55800  1.000 39.81583  ? 51   LEU A C     1 
ATOM   414  O O     . LEU A 1 71  ? 11.95100  23.19800  9.83400   1.000 37.43765  ? 51   LEU A O     1 
ATOM   415  C CB    . LEU A 1 71  ? 10.18600  21.73000  11.85100  1.000 38.23416  ? 51   LEU A CB    1 
ATOM   416  C CG    . LEU A 1 71  ? 9.35600   21.90300  13.12200  1.000 41.40561  ? 51   LEU A CG    1 
ATOM   417  C CD1   . LEU A 1 71  ? 7.87800   21.66700  12.85600  1.000 43.22498  ? 51   LEU A CD1   1 
ATOM   418  C CD2   . LEU A 1 71  ? 9.87500   20.98700  14.20100  1.000 38.24061  ? 51   LEU A CD2   1 
ATOM   419  N N     . LEU A 1 72  ? 13.13100  21.30200  10.21100  1.000 38.32398  ? 52   LEU A N     1 
ATOM   420  C CA    . LEU A 1 72  ? 13.76000  21.25000  8.89600   1.000 40.33385  ? 52   LEU A CA    1 
ATOM   421  C C     . LEU A 1 72  ? 13.44700  19.91300  8.23500   1.000 44.87041  ? 52   LEU A C     1 
ATOM   422  O O     . LEU A 1 72  ? 13.68800  18.85100  8.82300   1.000 45.11315  ? 52   LEU A O     1 
ATOM   423  C CB    . LEU A 1 72  ? 15.28200  21.44100  9.00600   1.000 43.39689  ? 52   LEU A CB    1 
ATOM   424  C CG    . LEU A 1 72  ? 15.74000  22.76900  9.61000   1.000 41.39225  ? 52   LEU A CG    1 
ATOM   425  C CD1   . LEU A 1 72  ? 17.24200  22.90400  9.51600   1.000 44.65721  ? 52   LEU A CD1   1 
ATOM   426  C CD2   . LEU A 1 72  ? 15.06100  23.92400  8.87900   1.000 37.76416  ? 52   LEU A CD2   1 
ATOM   427  N N     . GLY A 1 73  ? 12.91200  19.96800  7.01900   1.000 44.33045  ? 53   GLY A N     1 
ATOM   428  C CA    . GLY A 1 73  ? 12.68300  18.77800  6.23600   1.000 48.67470  ? 53   GLY A CA    1 
ATOM   429  C C     . GLY A 1 73  ? 13.91600  18.36500  5.45300   1.000 48.89557  ? 53   GLY A C     1 
ATOM   430  O O     . GLY A 1 73  ? 14.93900  19.05500  5.46000   1.000 47.25252  ? 53   GLY A O     1 
ATOM   431  N N     . PRO A 1 74  ? 13.82900  17.23000  4.74300   1.000 51.49612  ? 54   PRO A N     1 
ATOM   432  C CA    . PRO A 1 74  ? 15.02800  16.67900  4.08500   1.000 46.76284  ? 54   PRO A CA    1 
ATOM   433  C C     . PRO A 1 74  ? 15.64300  17.60300  3.05600   1.000 49.38452  ? 54   PRO A C     1 
ATOM   434  O O     . PRO A 1 74  ? 16.87300  17.62800  2.91400   1.000 51.46151  ? 54   PRO A O     1 
ATOM   435  C CB    . PRO A 1 74  ? 14.49900  15.39300  3.43200   1.000 52.89180  ? 54   PRO A CB    1 
ATOM   436  C CG    . PRO A 1 74  ? 13.28400  15.03100  4.23500   1.000 56.73361  ? 54   PRO A CG    1 
ATOM   437  C CD    . PRO A 1 74  ? 12.65700  16.35200  4.57000   1.000 54.63209  ? 54   PRO A CD    1 
ATOM   438  N N     . LYS A 1 75  ? 14.82300  18.35900  2.32100   1.000 50.32605  ? 55   LYS A N     1 
ATOM   439  C CA    . LYS A 1 75  ? 15.30800  19.24800  1.27600   1.000 47.21934  ? 55   LYS A CA    1 
ATOM   440  C C     . LYS A 1 75  ? 15.59300  20.66800  1.77700   1.000 49.83393  ? 55   LYS A C     1 
ATOM   441  O O     . LYS A 1 75  ? 15.81500  21.56200  0.95900   1.000 50.03997  ? 55   LYS A O     1 
ATOM   442  C CB    . LYS A 1 75  ? 14.31000  19.27000  0.11600   1.000 47.36342  ? 55   LYS A CB    1 
ATOM   443  C CG    . LYS A 1 75  ? 14.18200  17.90100  -0.58200  1.000 50.32273  ? 55   LYS A CG    1 
ATOM   444  C CD    . LYS A 1 75  ? 13.12400  17.88900  -1.68500  1.000 55.77999  ? 55   LYS A CD    1 
ATOM   445  C CE    . LYS A 1 75  ? 11.71500  17.72700  -1.11900  1.000 60.50806  ? 55   LYS A CE    1 
ATOM   446  N NZ    . LYS A 1 75  ? 10.77200  17.04700  -2.07300  1.000 58.17487  ? 55   LYS A NZ    1 
ATOM   447  N N     . ALA A 1 76  ? 15.62100  20.89000  3.09600   1.000 47.05168  ? 56   ALA A N     1 
ATOM   448  C CA    . ALA A 1 76  ? 16.06200  22.16600  3.66000   1.000 44.85138  ? 56   ALA A CA    1 
ATOM   449  C C     . ALA A 1 76  ? 17.47300  22.49800  3.17800   1.000 45.72480  ? 56   ALA A C     1 
ATOM   450  O O     . ALA A 1 76  ? 18.20000  21.60100  2.74800   1.000 49.98583  ? 56   ALA A O     1 
ATOM   451  C CB    . ALA A 1 76  ? 16.01700  22.11500  5.19200   1.000 41.39695  ? 56   ALA A CB    1 
ATOM   452  N N     . ARG A 1 77  ? 17.88100  23.76000  3.22800   1.000 43.77435  ? 57   ARG A N     1 
ATOM   453  C CA    . ARG A 1 77  ? 19.22700  24.11900  2.79500   1.000 41.81149  ? 57   ARG A CA    1 
ATOM   454  C C     . ARG A 1 77  ? 20.06600  24.60000  3.97000   1.000 38.61587  ? 57   ARG A C     1 
ATOM   455  O O     . ARG A 1 77  ? 19.53300  24.87800  5.04800   1.000 45.76056  ? 57   ARG A O     1 
ATOM   456  C CB    . ARG A 1 77  ? 19.19100  25.19400  1.69800   1.000 46.02221  ? 57   ARG A CB    1 
ATOM   457  C CG    . ARG A 1 77  ? 18.54900  26.47800  2.08600   1.000 43.23966  ? 57   ARG A CG    1 
ATOM   458  C CD    . ARG A 1 77  ? 18.03500  27.17700  0.83700   1.000 45.90917  ? 57   ARG A CD    1 
ATOM   459  N NE    . ARG A 1 77  ? 18.00800  28.61900  1.04100   1.000 48.29474  ? 57   ARG A NE    1 
ATOM   460  C CZ    . ARG A 1 77  ? 17.42600  29.49000  0.21900   1.000 49.65296  ? 57   ARG A CZ    1 
ATOM   461  N NH1   . ARG A 1 77  ? 16.79400  29.06300  -0.87800  1.000 52.29430  ? 57   ARG A NH1   1 
ATOM   462  N NH2   . ARG A 1 77  ? 17.46900  30.79000  0.50700   1.000 41.60547  ? 57   ARG A NH2   1 
ATOM   463  N N     . PRO A 1 78  ? 21.39000  24.67000  3.82000   1.000 37.31882  ? 58   PRO A N     1 
ATOM   464  C CA    . PRO A 1 78  ? 22.21900  25.01000  4.99400   1.000 38.27641  ? 58   PRO A CA    1 
ATOM   465  C C     . PRO A 1 78  ? 21.84900  26.32600  5.65800   1.000 34.37891  ? 58   PRO A C     1 
ATOM   466  O O     . PRO A 1 78  ? 21.92400  26.42600  6.89400   1.000 35.63511  ? 58   PRO A O     1 
ATOM   467  C CB    . PRO A 1 78  ? 23.63800  25.05400  4.41600   1.000 38.58530  ? 58   PRO A CB    1 
ATOM   468  C CG    . PRO A 1 78  ? 23.58500  24.11700  3.23900   1.000 40.26397  ? 58   PRO A CG    1 
ATOM   469  C CD    . PRO A 1 78  ? 22.21600  24.31200  2.65200   1.000 38.20530  ? 58   PRO A CD    1 
ATOM   470  N N     . GLU A 1 79  ? 21.44900  27.34900  4.88800   1.000 36.65646  ? 59   GLU A N     1 
ATOM   471  C CA    . GLU A 1 79  ? 21.10700  28.62000  5.52800   1.000 31.85816  ? 59   GLU A CA    1 
ATOM   472  C C     . GLU A 1 79  ? 19.89700  28.49400  6.45100   1.000 32.31110  ? 59   GLU A C     1 
ATOM   473  O O     . GLU A 1 79  ? 19.80400  29.21900  7.44300   1.000 35.61057  ? 59   GLU A O     1 
ATOM   474  C CB    . GLU A 1 79  ? 20.86000  29.71300  4.48300   1.000 35.58459  ? 59   GLU A CB    1 
ATOM   475  C CG    . GLU A 1 79  ? 20.84300  31.09800  5.11400   1.000 33.80151  ? 59   GLU A CG    1 
ATOM   476  C CD    . GLU A 1 79  ? 20.73800  32.22700  4.12700   1.000 36.68545  ? 59   GLU A CD    1 
ATOM   477  O OE1   . GLU A 1 79  ? 20.60700  31.97600  2.91300   1.000 34.30671  ? 59   GLU A OE1   1 
ATOM   478  O OE2   . GLU A 1 79  ? 20.79800  33.38100  4.60200   1.000 38.51955  ? 59   GLU A OE2   1 
ATOM   479  N N     . ASP A 1 80  ? 18.96800  27.58000  6.16300   1.000 36.38026  ? 60   ASP A N     1 
ATOM   480  C CA    . ASP A 1 80  ? 17.82300  27.39900  7.05200   1.000 34.24486  ? 60   ASP A CA    1 
ATOM   481  C C     . ASP A 1 80  ? 18.25000  27.14800  8.49300   1.000 36.66858  ? 60   ASP A C     1 
ATOM   482  O O     . ASP A 1 80  ? 17.70500  27.74900  9.43300   1.000 36.18902  ? 60   ASP A O     1 
ATOM   483  C CB    . ASP A 1 80  ? 16.94500  26.25600  6.55200   1.000 35.56526  ? 60   ASP A CB    1 
ATOM   484  C CG    . ASP A 1 80  ? 16.41100  26.50600  5.16500   1.000 40.45499  ? 60   ASP A CG    1 
ATOM   485  O OD1   . ASP A 1 80  ? 16.30200  27.68300  4.76300   1.000 41.19084  ? 60   ASP A OD1   1 
ATOM   486  O OD2   . ASP A 1 80  ? 16.09100  25.52200  4.46200   1.000 41.33881  ? 60   ASP A OD2   1 
ATOM   487  N N     . ARG A 1 81  ? 19.22300  26.25700  8.69900   1.000 37.37305  ? 61   ARG A N     1 
ATOM   488  C CA    . ARG A 1 81  ? 19.59700  25.91500  10.06400  1.000 37.07231  ? 61   ARG A CA    1 
ATOM   489  C C     . ARG A 1 81  ? 20.07800  27.14000  10.82600  1.000 37.97885  ? 61   ARG A C     1 
ATOM   490  O O     . ARG A 1 81  ? 19.86600  27.23700  12.04300  1.000 39.10213  ? 61   ARG A O     1 
ATOM   491  C CB    . ARG A 1 81  ? 20.67600  24.82100  10.07000  1.000 38.57865  ? 61   ARG A CB    1 
ATOM   492  C CG    . ARG A 1 81  ? 21.21300  24.54000  11.48700  1.000 43.79069  ? 61   ARG A CG    1 
ATOM   493  C CD    . ARG A 1 81  ? 22.21800  23.36500  11.54200  1.000 47.87023  ? 61   ARG A CD    1 
ATOM   494  N NE    . ARG A 1 81  ? 21.54800  22.06400  11.51000  1.000 53.44372  ? 61   ARG A NE    1 
ATOM   495  C CZ    . ARG A 1 81  ? 21.00000  21.49000  12.58000  1.000 52.49163  ? 61   ARG A CZ    1 
ATOM   496  N NH1   . ARG A 1 81  ? 21.03900  22.12200  13.74900  1.000 55.70730  ? 61   ARG A NH1   1 
ATOM   497  N NH2   . ARG A 1 81  ? 20.40700  20.29800  12.48400  1.000 50.72335  ? 61   ARG A NH2   1 
ATOM   498  N N     . ALA A 1 82  ? 20.68500  28.10900  10.12600  1.000 35.81735  ? 62   ALA A N     1 
ATOM   499  C CA    . ALA A 1 82  ? 21.19000  29.29600  10.81300  1.000 37.33600  ? 62   ALA A CA    1 
ATOM   500  C C     . ALA A 1 82  ? 20.08600  30.26900  11.23300  1.000 37.17985  ? 62   ALA A C     1 
ATOM   501  O O     . ALA A 1 82  ? 20.38500  31.25800  11.92200  1.000 37.16915  ? 62   ALA A O     1 
ATOM   502  C CB    . ALA A 1 82  ? 22.21100  30.00600  9.91300   1.000 34.91781  ? 62   ALA A CB    1 
ATOM   503  N N     . LEU A 1 83  ? 18.83000  30.03000  10.82800  1.000 37.33100  ? 63   LEU A N     1 
ATOM   504  C CA    . LEU A 1 83  ? 17.69100  30.81000  11.34000  1.000 36.21421  ? 63   LEU A CA    1 
ATOM   505  C C     . LEU A 1 83  ? 17.36600  30.51900  12.80700  1.000 38.17494  ? 63   LEU A C     1 
ATOM   506  O O     . LEU A 1 83  ? 16.71100  31.33500  13.46400  1.000 40.54853  ? 63   LEU A O     1 
ATOM   507  C CB    . LEU A 1 83  ? 16.44000  30.52400  10.50100  1.000 37.97120  ? 63   LEU A CB    1 
ATOM   508  C CG    . LEU A 1 83  ? 16.46300  30.83100  9.00500   1.000 34.68624  ? 63   LEU A CG    1 
ATOM   509  C CD1   . LEU A 1 83  ? 15.17200  30.36800  8.36000   1.000 38.06626  ? 63   LEU A CD1   1 
ATOM   510  C CD2   . LEU A 1 83  ? 16.68500  32.31200  8.73800   1.000 34.99755  ? 63   LEU A CD2   1 
ATOM   511  N N     . ALA A 1 84  ? 17.81700  29.38500  13.34600  1.000 40.71032  ? 64   ALA A N     1 
ATOM   512  C CA    . ALA A 1 84  ? 17.32500  28.92600  14.64300  1.000 40.99106  ? 64   ALA A CA    1 
ATOM   513  C C     . ALA A 1 84  ? 17.67100  29.87400  15.78700  1.000 48.22204  ? 64   ALA A C     1 
ATOM   514  O O     . ALA A 1 84  ? 16.90100  29.98300  16.75400  1.000 49.76492  ? 64   ALA A O     1 
ATOM   515  C CB    . ALA A 1 84  ? 17.86200  27.52700  14.94200  1.000 43.72433  ? 64   ALA A CB    1 
ATOM   516  N N     . GLY A 1 85  ? 18.80400  30.56100  15.71200  1.000 46.92014  ? 65   GLY A N     1 
ATOM   517  C CA    . GLY A 1 85  ? 19.14900  31.51200  16.77300  1.000 50.58500  ? 65   GLY A CA    1 
ATOM   518  C C     . GLY A 1 85  ? 19.08400  30.96500  18.18400  1.000 51.49553  ? 65   GLY A C     1 
ATOM   519  O O     . GLY A 1 85  ? 18.68600  31.69100  19.10300  1.000 54.27595  ? 65   GLY A O     1 
ATOM   520  N N     . GLY A 1 86  ? 19.43700  29.69300  18.38400  1.000 47.67925  ? 66   GLY A N     1 
ATOM   521  C CA    . GLY A 1 86  ? 19.38700  29.13700  19.73100  1.000 52.53330  ? 66   GLY A CA    1 
ATOM   522  C C     . GLY A 1 86  ? 18.10200  28.41500  20.12600  1.000 56.23747  ? 66   GLY A C     1 
ATOM   523  O O     . GLY A 1 86  ? 17.98900  27.96300  21.27500  1.000 57.76969  ? 66   GLY A O     1 
ATOM   524  N N     . ALA A 1 87  ? 17.12800  28.30500  19.23000  1.000 49.78004  ? 67   ALA A N     1 
ATOM   525  C CA    . ALA A 1 87  ? 16.00500  27.41900  19.46800  1.000 47.44684  ? 67   ALA A CA    1 
ATOM   526  C C     . ALA A 1 87  ? 16.43000  25.98100  19.22000  1.000 50.53293  ? 67   ALA A C     1 
ATOM   527  O O     . ALA A 1 87  ? 17.47100  25.71100  18.61200  1.000 48.35966  ? 67   ALA A O     1 
ATOM   528  C CB    . ALA A 1 87  ? 14.83200  27.76700  18.55000  1.000 45.56283  ? 67   ALA A CB    1 
ATOM   529  N N     . GLU A 1 88  ? 15.60100  25.05400  19.69400  1.000 49.06860  ? 68   GLU A N     1 
ATOM   530  C CA    . GLU A 1 88  ? 15.79100  23.65400  19.35700  1.000 49.36718  ? 68   GLU A CA    1 
ATOM   531  C C     . GLU A 1 88  ? 15.57800  23.44900  17.86700  1.000 47.28063  ? 68   GLU A C     1 
ATOM   532  O O     . GLU A 1 88  ? 14.63200  23.99500  17.28500  1.000 46.89936  ? 68   GLU A O     1 
ATOM   533  C CB    . GLU A 1 88  ? 14.81100  22.78900  20.14500  1.000 51.42494  ? 68   GLU A CB    1 
ATOM   534  C CG    . GLU A 1 88  ? 14.78600  21.36000  19.68300  1.000 53.88084  ? 68   GLU A CG    1 
ATOM   535  C CD    . GLU A 1 88  ? 14.15100  20.43900  20.68900  1.000 63.09403  ? 68   GLU A CD    1 
ATOM   536  O OE1   . GLU A 1 88  ? 12.97300  20.68600  21.02800  1.000 61.74122  ? 68   GLU A OE1   1 
ATOM   537  O OE2   . GLU A 1 88  ? 14.83400  19.47800  21.13400  1.000 70.63754  ? 68   GLU A OE2   1 
ATOM   538  N N     . VAL A 1 89  ? 16.45700  22.65400  17.24900  1.000 49.72102  ? 69   VAL A N     1 
ATOM   539  C CA    . VAL A 1 89  ? 16.37500  22.31600  15.82800  1.000 46.10337  ? 69   VAL A CA    1 
ATOM   540  C C     . VAL A 1 89  ? 16.02800  20.83600  15.69300  1.000 53.70212  ? 69   VAL A C     1 
ATOM   541  O O     . VAL A 1 89  ? 16.80100  19.97400  16.13200  1.000 54.69850  ? 69   VAL A O     1 
ATOM   542  C CB    . VAL A 1 89  ? 17.68800  22.62600  15.09400  1.000 48.38002  ? 69   VAL A CB    1 
ATOM   543  C CG1   . VAL A 1 89  ? 17.60400  22.21000  13.60700  1.000 42.37934  ? 69   VAL A CG1   1 
ATOM   544  C CG2   . VAL A 1 89  ? 18.02200  24.08200  15.22200  1.000 48.10063  ? 69   VAL A CG2   1 
ATOM   545  N N     . LEU A 1 90  ? 14.88900  20.53900  15.06000  1.000 47.59117  ? 70   LEU A N     1 
ATOM   546  C CA    . LEU A 1 90  ? 14.45100  19.16800  14.80900  1.000 47.35578  ? 70   LEU A CA    1 
ATOM   547  C C     . LEU A 1 90  ? 14.51100  18.85200  13.32100  1.000 50.47062  ? 70   LEU A C     1 
ATOM   548  O O     . LEU A 1 90  ? 13.99700  19.61500  12.49100  1.000 45.85663  ? 70   LEU A O     1 
ATOM   549  C CB    . LEU A 1 90  ? 13.02600  18.93100  15.31000  1.000 41.56597  ? 70   LEU A CB    1 
ATOM   550  C CG    . LEU A 1 90  ? 12.78600  19.11800  16.80000  1.000 50.87674  ? 70   LEU A CG    1 
ATOM   551  C CD1   . LEU A 1 90  ? 11.33400  18.79800  17.09000  1.000 56.52027  ? 70   LEU A CD1   1 
ATOM   552  C CD2   . LEU A 1 90  ? 13.73100  18.22100  17.60200  1.000 61.09712  ? 70   LEU A CD2   1 
ATOM   553  N N     . GLU A 1 91  ? 15.09200  17.70200  12.99900  1.000 52.25725  ? 71   GLU A N     1 
ATOM   554  C CA    . GLU A 1 91  ? 15.15300  17.18900  11.63600  1.000 51.03656  ? 71   GLU A CA    1 
ATOM   555  C C     . GLU A 1 91  ? 14.00900  16.20700  11.38800  1.000 53.37963  ? 71   GLU A C     1 
ATOM   556  O O     . GLU A 1 91  ? 13.90800  15.17800  12.06200  1.000 59.45209  ? 71   GLU A O     1 
ATOM   557  C CB    . GLU A 1 91  ? 16.49600  16.50500  11.40700  1.000 56.26191  ? 71   GLU A CB    1 
ATOM   558  C CG    . GLU A 1 91  ? 17.65600  17.44700  11.30900  1.000 56.38449  ? 71   GLU A CG    1 
ATOM   559  C CD    . GLU A 1 91  ? 17.66900  18.17300  9.98700   1.000 57.37983  ? 71   GLU A CD    1 
ATOM   560  O OE1   . GLU A 1 91  ? 16.83300  17.84100  9.11100   1.000 60.75535  ? 71   GLU A OE1   1 
ATOM   561  O OE2   . GLU A 1 91  ? 18.51500  19.07600  9.82500   1.000 64.02239  ? 71   GLU A OE2   1 
ATOM   562  N N     . LEU A 1 92  ? 13.16500  16.50600  10.41000  1.000 48.20180  ? 72   LEU A N     1 
ATOM   563  C CA    . LEU A 1 92  ? 12.00400  15.68300  10.10200  1.000 50.96356  ? 72   LEU A CA    1 
ATOM   564  C C     . LEU A 1 92  ? 12.18600  14.98100  8.76400   1.000 51.29583  ? 72   LEU A C     1 
ATOM   565  O O     . LEU A 1 92  ? 12.63300  15.59000  7.78600   1.000 49.65196  ? 72   LEU A O     1 
ATOM   566  C CB    . LEU A 1 92  ? 10.72900  16.52200  10.06100  1.000 47.18580  ? 72   LEU A CB    1 
ATOM   567  C CG    . LEU A 1 92  ? 10.33100  17.21900  11.35500  1.000 47.14929  ? 72   LEU A CG    1 
ATOM   568  C CD1   . LEU A 1 92  ? 8.95300   17.86100  11.19900  1.000 48.11845  ? 72   LEU A CD1   1 
ATOM   569  C CD2   . LEU A 1 92  ? 10.34500  16.25000  12.50300  1.000 44.93750  ? 72   LEU A CD2   1 
ATOM   570  N N     . SER A 1 93  ? 11.83100  13.69700  8.72300   1.000 55.21915  ? 73   SER A N     1 
ATOM   571  C CA    . SER A 1 93  ? 11.75700  12.97400  7.46000   1.000 57.59438  ? 73   SER A CA    1 
ATOM   572  C C     . SER A 1 93  ? 10.57600  13.48300  6.64200   1.000 55.72894  ? 73   SER A C     1 
ATOM   573  O O     . SER A 1 93  ? 9.70200   14.18900  7.14900   1.000 52.17409  ? 73   SER A O     1 
ATOM   574  C CB    . SER A 1 93  ? 11.59300  11.48200  7.71600   1.000 59.74986  ? 73   SER A CB    1 
ATOM   575  O OG    . SER A 1 93  ? 10.48500  11.27600  8.57200   1.000 60.80764  ? 73   SER A OG    1 
ATOM   576  N N     . GLU A 1 94  ? 10.52800  13.08500  5.36800   1.000 56.62396  ? 74   GLU A N     1 
ATOM   577  C CA    . GLU A 1 94  ? 9.37600   13.44200  4.53600   1.000 60.91640  ? 74   GLU A CA    1 
ATOM   578  C C     . GLU A 1 94  ? 8.06000   12.97800  5.15900   1.000 62.87290  ? 74   GLU A C     1 
ATOM   579  O O     . GLU A 1 94  ? 7.03100   13.66200  5.03700   1.000 61.67085  ? 74   GLU A O     1 
ATOM   580  C CB    . GLU A 1 94  ? 9.52300   12.86400  3.12900   1.000 61.24628  ? 74   GLU A CB    1 
ATOM   581  C CG    . GLU A 1 94  ? 10.39800  13.71700  2.19000   1.000 68.01173  ? 74   GLU A CG    1 
ATOM   582  C CD    . GLU A 1 94  ? 9.81500   15.11800  1.89800   1.000 67.16416  ? 74   GLU A CD    1 
ATOM   583  O OE1   . GLU A 1 94  ? 8.57000   15.27900  1.82200   1.000 67.96019  ? 74   GLU A OE1   1 
ATOM   584  O OE2   . GLU A 1 94  ? 10.61300  16.06700  1.74000   1.000 62.79271  ? 74   GLU A OE2   1 
ATOM   585  N N     . ARG A 1 95  ? 8.07300   11.83000  5.84200   1.000 61.35026  ? 75   ARG A N     1 
ATOM   586  C CA    . ARG A 1 95  ? 6.83200   11.27500  6.37500   1.000 60.69523  ? 75   ARG A CA    1 
ATOM   587  C C     . ARG A 1 95  ? 6.38800   11.99200  7.64600   1.000 56.85124  ? 75   ARG A C     1 
ATOM   588  O O     . ARG A 1 95  ? 5.19100   12.24000  7.83000   1.000 58.01878  ? 75   ARG A O     1 
ATOM   589  C CB    . ARG A 1 95  ? 6.99100   9.77400   6.63600   1.000 62.14596  ? 75   ARG A CB    1 
ATOM   590  C CG    . ARG A 1 95  ? 7.26000   8.97000   5.37700   1.000 67.74802  ? 75   ARG A CG    1 
ATOM   591  C CD    . ARG A 1 95  ? 7.81900   7.58400   5.69800   1.000 68.42114  ? 75   ARG A CD    1 
ATOM   592  N NE    . ARG A 1 95  ? 8.87300   7.61200   6.71500   1.000 70.42218  ? 75   ARG A NE    1 
ATOM   593  C CZ    . ARG A 1 95  ? 10.09500  8.12100   6.53800   1.000 75.94129  ? 75   ARG A CZ    1 
ATOM   594  N NH1   . ARG A 1 95  ? 10.44500  8.67900   5.37400   1.000 68.71370  ? 75   ARG A NH1   1 
ATOM   595  N NH2   . ARG A 1 95  ? 10.97900  8.08100   7.53500   1.000 74.60114  ? 75   ARG A NH2   1 
ATOM   596  N N     . ALA A 1 96  ? 7.32400   12.31300  8.54600   1.000 55.54404  ? 76   ALA A N     1 
ATOM   597  C CA    . ALA A 1 96  ? 6.94100   13.07500  9.72900   1.000 53.84167  ? 76   ALA A CA    1 
ATOM   598  C C     . ALA A 1 96  ? 6.52600   14.49000  9.33700   1.000 56.18236  ? 76   ALA A C     1 
ATOM   599  O O     . ALA A 1 96  ? 5.57600   15.05100  9.90100   1.000 53.56201  ? 76   ALA A O     1 
ATOM   600  C CB    . ALA A 1 96  ? 8.08400   13.08500  10.73800  1.000 50.01525  ? 76   ALA A CB    1 
ATOM   601  N N     . LEU A 1 97  ? 7.20800   15.05900  8.33700   1.000 53.17584  ? 77   LEU A N     1 
ATOM   602  C CA    . LEU A 1 97  ? 6.87600   16.39400  7.84400   1.000 53.62581  ? 77   LEU A CA    1 
ATOM   603  C C     . LEU A 1 97  ? 5.44900   16.43700  7.32600   1.000 55.36063  ? 77   LEU A C     1 
ATOM   604  O O     . LEU A 1 97  ? 4.71600   17.40900  7.57000   1.000 57.37422  ? 77   LEU A O     1 
ATOM   605  C CB    . LEU A 1 97  ? 7.86000   16.79200  6.74000   1.000 49.12347  ? 77   LEU A CB    1 
ATOM   606  C CG    . LEU A 1 97  ? 7.91300   18.20500  6.13900   1.000 56.70357  ? 77   LEU A CG    1 
ATOM   607  C CD1   . LEU A 1 97  ? 8.68200   19.15500  7.04500   1.000 52.56699  ? 77   LEU A CD1   1 
ATOM   608  C CD2   . LEU A 1 97  ? 8.55200   18.18100  4.74700   1.000 49.97298  ? 77   LEU A CD2   1 
ATOM   609  N N     . ALA A 1 98  ? 5.02900   15.38000  6.62300   1.000 55.68670  ? 78   ALA A N     1 
ATOM   610  C CA    . ALA A 1 98  ? 3.67100   15.33300  6.09000   1.000 57.95116  ? 78   ALA A CA    1 
ATOM   611  C C     . ALA A 1 98  ? 2.62500   15.43200  7.20100   1.000 56.28590  ? 78   ALA A C     1 
ATOM   612  O O     . ALA A 1 98  ? 1.58300   16.07300  7.01900   1.000 58.81006  ? 78   ALA A O     1 
ATOM   613  C CB    . ALA A 1 98  ? 3.47700   14.06200  5.27100   1.000 58.61706  ? 78   ALA A CB    1 
ATOM   614  N N     . ARG A 1 99  ? 2.89500   14.83000  8.36700   1.000 55.35482  ? 79   ARG A N     1 
ATOM   615  C CA    . ARG A 1 99  ? 1.92600   14.87200  9.46600   1.000 57.80437  ? 79   ARG A CA    1 
ATOM   616  C C     . ARG A 1 99  ? 1.80500   16.27000  10.06300  1.000 55.84874  ? 79   ARG A C     1 
ATOM   617  O O     . ARG A 1 99  ? 0.71500   16.67600  10.49300  1.000 51.90806  ? 79   ARG A O     1 
ATOM   618  C CB    . ARG A 1 99  ? 2.31200   13.87900  10.56500  1.000 61.09404  ? 79   ARG A CB    1 
ATOM   619  C CG    . ARG A 1 99  ? 2.10100   12.40400  10.22600  1.000 67.04109  ? 79   ARG A CG    1 
ATOM   620  C CD    . ARG A 1 99  ? 0.64300   12.09100  9.86200   1.000 64.48770  ? 79   ARG A CD    1 
ATOM   621  N NE    . ARG A 1 99  ? 0.42400   12.22100  8.42300   1.000 69.71612  ? 79   ARG A NE    1 
ATOM   622  C CZ    . ARG A 1 99  ? 0.66800   11.25500  7.53900   1.000 74.99410  ? 79   ARG A CZ    1 
ATOM   623  N NH1   . ARG A 1 99  ? 0.44400   11.46600  6.24600   1.000 73.03056  ? 79   ARG A NH1   1 
ATOM   624  N NH2   . ARG A 1 99  ? 1.13000   10.07600  7.94900   1.000 77.53750  ? 79   ARG A NH2   1 
ATOM   625  N N     . VAL A 1 100 ? 2.91900   16.99900  10.13900  1.000 50.63097  ? 80   VAL A N     1 
ATOM   626  C CA    . VAL A 1 100 ? 2.90200   18.31400  10.76400  1.000 50.96718  ? 80   VAL A CA    1 
ATOM   627  C C     . VAL A 1 100 ? 2.40200   19.38800  9.79900   1.000 52.28735  ? 80   VAL A C     1 
ATOM   628  O O     . VAL A 1 100 ? 1.82200   20.39300  10.23400  1.000 50.77966  ? 80   VAL A O     1 
ATOM   629  C CB    . VAL A 1 100 ? 4.29700   18.67400  11.30900  1.000 51.58153  ? 80   VAL A CB    1 
ATOM   630  C CG1   . VAL A 1 100 ? 4.19400   19.90200  12.17500  1.000 52.57582  ? 80   VAL A CG1   1 
ATOM   631  C CG2   . VAL A 1 100 ? 4.89500   17.51700  12.12200  1.000 53.32512  ? 80   VAL A CG2   1 
ATOM   632  N N     . SER A 1 101 ? 2.60400   19.20500  8.49700   1.000 48.47011  ? 81   SER A N     1 
ATOM   633  C CA    . SER A 1 101 ? 2.24000   20.22700  7.53100   1.000 46.69396  ? 81   SER A CA    1 
ATOM   634  C C     . SER A 1 101 ? 0.72700   20.41300  7.45000   1.000 50.78665  ? 81   SER A C     1 
ATOM   635  O O     . SER A 1 101 ? -0.04800  19.46400  7.57800   1.000 46.08805  ? 81   SER A O     1 
ATOM   636  C CB    . SER A 1 101 ? 2.76700   19.86200  6.15100   1.000 41.80820  ? 81   SER A CB    1 
ATOM   637  O OG    . SER A 1 101 ? 2.18500   20.69200  5.16800   1.000 46.55661  ? 81   SER A OG    1 
ATOM   638  N N     . ALA A 1 102 ? 0.31400   21.65600  7.20400   1.000 49.37686  ? 82   ALA A N     1 
ATOM   639  C CA    . ALA A 1 102 ? -1.07100  21.96100  6.86700   1.000 51.18263  ? 82   ALA A CA    1 
ATOM   640  C C     . ALA A 1 102 ? -1.31400  21.94000  5.35900   1.000 52.99719  ? 82   ALA A C     1 
ATOM   641  O O     . ALA A 1 102 ? -2.38100  22.37200  4.89400   1.000 50.31607  ? 82   ALA A O     1 
ATOM   642  C CB    . ALA A 1 102 ? -1.46500  23.33000  7.44500   1.000 48.68424  ? 82   ALA A CB    1 
ATOM   643  N N     . ARG A 1 103 ? -0.35200  21.45200  4.58400   1.000 51.83705  ? 83   ARG A N     1 
ATOM   644  C CA    . ARG A 1 103 ? -0.41800  21.53800  3.13900   1.000 52.19428  ? 83   ARG A CA    1 
ATOM   645  C C     . ARG A 1 103 ? -0.38600  20.15400  2.51600   1.000 57.94775  ? 83   ARG A C     1 
ATOM   646  O O     . ARG A 1 103 ? 0.25600   19.23200  3.03400   1.000 57.73446  ? 83   ARG A O     1 
ATOM   647  C CB    . ARG A 1 103 ? 0.73800   22.35600  2.59400   1.000 52.16641  ? 83   ARG A CB    1 
ATOM   648  C CG    . ARG A 1 103 ? 0.89500   23.70800  3.27000   1.000 47.41585  ? 83   ARG A CG    1 
ATOM   649  C CD    . ARG A 1 103 ? 2.09300   24.44100  2.68600   1.000 53.01174  ? 83   ARG A CD    1 
ATOM   650  N NE    . ARG A 1 103 ? 2.19200   25.82500  3.16100   1.000 48.71121  ? 83   ARG A NE    1 
ATOM   651  C CZ    . ARG A 1 103 ? 3.12100   26.66500  2.72700   1.000 48.35220  ? 83   ARG A CZ    1 
ATOM   652  N NH1   . ARG A 1 103 ? 4.00700   26.24600  1.82700   1.000 45.58639  ? 83   ARG A NH1   1 
ATOM   653  N NH2   . ARG A 1 103 ? 3.16800   27.91100  3.18200   1.000 44.58496  ? 83   ARG A NH2   1 
ATOM   654  N N     . GLU A 1 104 ? -1.08100  20.01800  1.38500   1.000 61.82694  ? 84   GLU A N     1 
ATOM   655  C CA    . GLU A 1 104 ? -0.92400  18.80600  0.59300   1.000 61.70048  ? 84   GLU A CA    1 
ATOM   656  C C     . GLU A 1 104 ? 0.54200   18.59400  0.24700   1.000 59.70363  ? 84   GLU A C     1 
ATOM   657  O O     . GLU A 1 104 ? 1.07100   17.48700  0.39400   1.000 59.95334  ? 84   GLU A O     1 
ATOM   658  C CB    . GLU A 1 104 ? -1.78600  18.88600  -0.66500  1.000 63.57764  ? 84   GLU A CB    1 
ATOM   659  C CG    . GLU A 1 104 ? -1.95200  17.55300  -1.39300  1.000 71.08799  ? 84   GLU A CG    1 
ATOM   660  C CD    . GLU A 1 104 ? -3.28400  17.43600  -2.14400  1.000 74.46802  ? 84   GLU A CD    1 
ATOM   661  O OE1   . GLU A 1 104 ? -3.94800  16.37800  -2.02000  1.000 73.90655  ? 84   GLU A OE1   1 
ATOM   662  O OE2   . GLU A 1 104 ? -3.66700  18.39800  -2.85000  1.000 71.18080  ? 84   GLU A OE2   1 
ATOM   663  N N     . ASN A 1 105 ? 1.22500   19.66200  -0.15700  1.000 57.47624  ? 85   ASN A N     1 
ATOM   664  C CA    . ASN A 1 105 ? 2.65300   19.61200  -0.42700  1.000 56.51831  ? 85   ASN A CA    1 
ATOM   665  C C     . ASN A 1 105 ? 3.42400   20.34000  0.67200   1.000 58.99274  ? 85   ASN A C     1 
ATOM   666  O O     . ASN A 1 105 ? 3.40300   21.57900  0.71900   1.000 54.51582  ? 85   ASN A O     1 
ATOM   667  C CB    . ASN A 1 105 ? 2.93600   20.23900  -1.78700  1.000 59.76300  ? 85   ASN A CB    1 
ATOM   668  C CG    . ASN A 1 105 ? 4.30600   19.89800  -2.29400  1.000 66.27099  ? 85   ASN A CG    1 
ATOM   669  O OD1   . ASN A 1 105 ? 5.26100   19.80300  -1.51500  1.000 67.32150  ? 85   ASN A OD1   1 
ATOM   670  N ND2   . ASN A 1 105 ? 4.42100   19.69800  -3.60600  1.000 69.06385  ? 85   ASN A ND2   1 
ATOM   671  N N     . PRO A 1 106 ? 4.13200   19.63200  1.54900   1.000 56.14548  ? 86   PRO A N     1 
ATOM   672  C CA    . PRO A 1 106 ? 4.68400   20.27400  2.75300   1.000 52.67486  ? 86   PRO A CA    1 
ATOM   673  C C     . PRO A 1 106 ? 5.82700   21.22800  2.44800   1.000 53.23402  ? 86   PRO A C     1 
ATOM   674  O O     . PRO A 1 106 ? 6.60700   21.03200  1.51500   1.000 52.78753  ? 86   PRO A O     1 
ATOM   675  C CB    . PRO A 1 106 ? 5.18300   19.08700  3.58900   1.000 53.63838  ? 86   PRO A CB    1 
ATOM   676  C CG    . PRO A 1 106 ? 4.47900   17.86600  2.98600   1.000 55.69290  ? 86   PRO A CG    1 
ATOM   677  C CD    . PRO A 1 106 ? 4.35400   18.17800  1.53900   1.000 53.55532  ? 86   PRO A CD    1 
ATOM   678  N N     . ALA A 1 107 ? 5.92200   22.27700  3.26300   1.000 50.95878  ? 87   ALA A N     1 
ATOM   679  C CA    . ALA A 1 107 ? 7.10300   23.12700  3.24300   1.000 45.01788  ? 87   ALA A CA    1 
ATOM   680  C C     . ALA A 1 107 ? 8.26700   22.40700  3.91700   1.000 45.66257  ? 87   ALA A C     1 
ATOM   681  O O     . ALA A 1 107 ? 8.07600   21.52000  4.75500   1.000 44.80538  ? 87   ALA A O     1 
ATOM   682  C CB    . ALA A 1 107 ? 6.82800   24.45000  3.96000   1.000 41.55816  ? 87   ALA A CB    1 
ATOM   683  N N     . GLN A 1 108 ? 9.48400   22.81000  3.54400   1.000 42.35521  ? 88   GLN A N     1 
ATOM   684  C CA    . GLN A 1 108 ? 10.72500  22.25100  4.07600   1.000 41.15594  ? 88   GLN A CA    1 
ATOM   685  C C     . GLN A 1 108 ? 11.21300  22.97100  5.33100   1.000 41.20906  ? 88   GLN A C     1 
ATOM   686  O O     . GLN A 1 108 ? 12.08600  22.44700  6.04200   1.000 39.93778  ? 88   GLN A O     1 
ATOM   687  C CB    . GLN A 1 108 ? 11.82400  22.30800  3.00200   1.000 40.49521  ? 88   GLN A CB    1 
ATOM   688  C CG    . GLN A 1 108 ? 11.58000  21.37700  1.82100   1.000 42.71844  ? 88   GLN A CG    1 
ATOM   689  C CD    . GLN A 1 108 ? 11.43200  19.92400  2.25100   1.000 49.05915  ? 88   GLN A CD    1 
ATOM   690  O OE1   . GLN A 1 108 ? 12.24600  19.40700  3.02100   1.000 45.43364  ? 88   GLN A OE1   1 
ATOM   691  N NE2   . GLN A 1 108 ? 10.38600  19.26200  1.76100   1.000 50.69113  ? 88   GLN A NE2   1 
ATOM   692  N N     . VAL A 1 109 ? 10.66200  24.14500  5.63200   1.000 37.68261  ? 89   VAL A N     1 
ATOM   693  C CA    . VAL A 1 109 ? 11.02700  24.90300  6.82400   1.000 39.00622  ? 89   VAL A CA    1 
ATOM   694  C C     . VAL A 1 109 ? 9.74700   25.29800  7.55600   1.000 36.39839  ? 89   VAL A C     1 
ATOM   695  O O     . VAL A 1 109 ? 8.83000   25.86200  6.94800   1.000 36.03602  ? 89   VAL A O     1 
ATOM   696  C CB    . VAL A 1 109 ? 11.84000  26.16100  6.45600   1.000 38.01310  ? 89   VAL A CB    1 
ATOM   697  C CG1   . VAL A 1 109 ? 12.36100  26.87600  7.72300   1.000 37.66988  ? 89   VAL A CG1   1 
ATOM   698  C CG2   . VAL A 1 109 ? 12.96700  25.84000  5.47600   1.000 35.97950  ? 89   VAL A CG2   1 
ATOM   699  N N     . LEU A 1 110 ? 9.71300   24.98800  8.84700   1.000 32.86757  ? 90   LEU A N     1 
ATOM   700  C CA    . LEU A 1 110 ? 8.55900   25.34700  9.70400   1.000 34.42622  ? 90   LEU A CA    1 
ATOM   701  C C     . LEU A 1 110 ? 9.09300   25.81900  11.06600  1.000 37.42043  ? 90   LEU A C     1 
ATOM   702  O O     . LEU A 1 110 ? 10.17400  25.35400  11.44200  1.000 37.90701  ? 90   LEU A O     1 
ATOM   703  C CB    . LEU A 1 110 ? 7.66600   24.12000  9.86500   1.000 40.43958  ? 90   LEU A CB    1 
ATOM   704  C CG    . LEU A 1 110 ? 6.99400   23.54400  8.61700   1.000 40.01508  ? 90   LEU A CG    1 
ATOM   705  C CD1   . LEU A 1 110 ? 7.83900   22.41900  8.06400   1.000 44.94076  ? 90   LEU A CD1   1 
ATOM   706  C CD2   . LEU A 1 110 ? 5.62700   23.01100  8.99700   1.000 39.24848  ? 90   LEU A CD2   1 
ATOM   707  N N     . GLY A 1 111 ? 8.38100   26.70800  11.76200  1.000 36.04026  ? 91   GLY A N     1 
ATOM   708  C CA    . GLY A 1 111 ? 8.77000   27.13300  13.09800  1.000 35.81652  ? 91   GLY A CA    1 
ATOM   709  C C     . GLY A 1 111 ? 7.60400   27.05700  14.05800  1.000 35.39373  ? 91   GLY A C     1 
ATOM   710  O O     . GLY A 1 111 ? 6.47000   27.37900  13.70000  1.000 38.11524  ? 91   GLY A O     1 
ATOM   711  N N     . VAL A 1 112 ? 7.94500   26.65000  15.27800  1.000 35.55130  ? 92   VAL A N     1 
ATOM   712  C CA    . VAL A 1 112 ? 6.97500   26.71000  16.39500  1.000 35.84376  ? 92   VAL A CA    1 
ATOM   713  C C     . VAL A 1 112 ? 7.35900   27.99300  17.14100  1.000 39.39285  ? 92   VAL A C     1 
ATOM   714  O O     . VAL A 1 112 ? 8.48900   28.08000  17.64000  1.000 35.05462  ? 92   VAL A O     1 
ATOM   715  C CB    . VAL A 1 112 ? 7.03500   25.50000  17.33700  1.000 40.57618  ? 92   VAL A CB    1 
ATOM   716  C CG1   . VAL A 1 112 ? 6.00900   25.61300  18.45400  1.000 40.02808  ? 92   VAL A CG1   1 
ATOM   717  C CG2   . VAL A 1 112 ? 6.88300   24.19200  16.57800  1.000 35.17122  ? 92   VAL A CG2   1 
ATOM   718  N N     . PHE A 1 113 ? 6.45200   28.96000  17.15700  1.000 36.71429  ? 93   PHE A N     1 
ATOM   719  C CA    . PHE A 1 113 ? 6.73800   30.25200  17.81000  1.000 35.19534  ? 93   PHE A CA    1 
ATOM   720  C C     . PHE A 1 113 ? 5.77600   30.45400  18.95400  1.000 39.66884  ? 93   PHE A C     1 
ATOM   721  O O     . PHE A 1 113 ? 4.73400   29.79100  18.99600  1.000 37.50141  ? 93   PHE A O     1 
ATOM   722  C CB    . PHE A 1 113 ? 6.53300   31.36100  16.78200  1.000 33.09065  ? 93   PHE A CB    1 
ATOM   723  C CG    . PHE A 1 113 ? 7.56500   31.51500  15.67700  1.000 30.90892  ? 93   PHE A CG    1 
ATOM   724  C CD1   . PHE A 1 113 ? 7.49300   30.74900  14.52100  1.000 33.09733  ? 93   PHE A CD1   1 
ATOM   725  C CD2   . PHE A 1 113 ? 8.58000   32.45600  15.77900  1.000 33.72865  ? 93   PHE A CD2   1 
ATOM   726  C CE1   . PHE A 1 113 ? 8.42200   30.90700  13.50900  1.000 29.27985  ? 93   PHE A CE1   1 
ATOM   727  C CE2   . PHE A 1 113 ? 9.50600   32.60800  14.76300  1.000 35.64984  ? 93   PHE A CE2   1 
ATOM   728  C CZ    . PHE A 1 113 ? 9.42500   31.83400  13.63300  1.000 33.53247  ? 93   PHE A CZ    1 
ATOM   729  N N     . ARG A 1 114 ? 6.11800   31.36300  19.85600  1.000 36.37383  ? 94   ARG A N     1 
ATOM   730  C CA    . ARG A 1 114 ? 5.18100   31.72100  20.94100  1.000 36.92763  ? 94   ARG A CA    1 
ATOM   731  C C     . ARG A 1 114 ? 4.17200   32.71600  20.36700  1.000 39.46703  ? 94   ARG A C     1 
ATOM   732  O O     . ARG A 1 114 ? 4.56900   33.59200  19.59300  1.000 34.04757  ? 94   ARG A O     1 
ATOM   733  C CB    . ARG A 1 114 ? 5.90400   32.33800  22.13600  1.000 40.29810  ? 94   ARG A CB    1 
ATOM   734  C CG    . ARG A 1 114 ? 6.45200   31.30300  23.10500  1.000 51.89925  ? 94   ARG A CG    1 
ATOM   735  C CD    . ARG A 1 114 ? 6.65900   31.89600  24.48700  1.000 59.77637  ? 94   ARG A CD    1 
ATOM   736  N NE    . ARG A 1 114 ? 5.50400   32.68900  24.92000  1.000 62.06354  ? 94   ARG A NE    1 
ATOM   737  C CZ    . ARG A 1 114 ? 4.43700   32.19200  25.52900  1.000 64.73142  ? 94   ARG A CZ    1 
ATOM   738  N NH1   . ARG A 1 114 ? 4.43500   32.03500  26.83900  1.000 58.55912  ? 94   ARG A NH1   1 
ATOM   739  N NH2   . ARG A 1 114 ? 3.37400   31.85300  24.82500  1.000 58.72830  ? 94   ARG A NH2   1 
ATOM   740  N N     . LEU A 1 115 ? 2.91100   32.54700  20.74300  1.000 36.42376  ? 95   LEU A N     1 
ATOM   741  C CA    . LEU A 1 115 ? 1.86400   33.44600  20.21500  1.000 36.06033  ? 95   LEU A CA    1 
ATOM   742  C C     . LEU A 1 115 ? 2.19000   34.86900  20.67600  1.000 36.05191  ? 95   LEU A C     1 
ATOM   743  O O     . LEU A 1 115 ? 2.51500   35.06200  21.84600  1.000 39.49426  ? 95   LEU A O     1 
ATOM   744  C CB    . LEU A 1 115 ? 0.46300   33.00000  20.62900  1.000 36.54688  ? 95   LEU A CB    1 
ATOM   745  C CG    . LEU A 1 115 ? -0.13200  31.84300  19.82100  1.000 38.56389  ? 95   LEU A CG    1 
ATOM   746  C CD1   . LEU A 1 115 ? -1.22300  31.14300  20.60300  1.000 34.11162  ? 95   LEU A CD1   1 
ATOM   747  C CD2   . LEU A 1 115 ? -0.67000  32.33900  18.49600  1.000 37.36301  ? 95   LEU A CD2   1 
ATOM   748  N N     . PRO A 1 116 ? 2.10900   35.85600  19.77000  1.000 36.48643  ? 96   PRO A N     1 
ATOM   749  C CA    . PRO A 1 116 ? 2.38500   37.23100  20.14300  1.000 39.31729  ? 96   PRO A CA    1 
ATOM   750  C C     . PRO A 1 116 ? 1.37300   37.88500  21.09300  1.000 41.12092  ? 96   PRO A C     1 
ATOM   751  O O     . PRO A 1 116 ? 0.18400   37.56200  21.04000  1.000 42.44181  ? 96   PRO A O     1 
ATOM   752  C CB    . PRO A 1 116 ? 2.40200   37.90300  18.77500  1.000 37.46751  ? 96   PRO A CB    1 
ATOM   753  C CG    . PRO A 1 116 ? 1.51300   37.06300  17.92100  1.000 40.42128  ? 96   PRO A CG    1 
ATOM   754  C CD    . PRO A 1 116 ? 1.78100   35.65500  18.38100  1.000 37.27921  ? 96   PRO A CD    1 
ATOM   755  N N     . ARG A 1 117 ? 1.84800   38.79000  21.94800  1.000 44.32679  ? 97   ARG A N     1 
ATOM   756  C CA    . ARG A 1 117 ? 0.92800   39.55000  22.82900  1.000 46.00860  ? 97   ARG A CA    1 
ATOM   757  C C     . ARG A 1 117 ? 0.80900   40.96900  22.26800  1.000 50.71911  ? 97   ARG A C     1 
ATOM   758  O O     . ARG A 1 117 ? 1.78800   41.72900  22.37900  1.000 58.40559  ? 97   ARG A O     1 
ATOM   759  C CB    . ARG A 1 117 ? 1.44900   39.63300  24.26500  1.000 46.81224  ? 97   ARG A CB    1 
ATOM   760  C CG    . ARG A 1 117 ? 1.45400   38.32900  25.04500  1.000 48.56676  ? 97   ARG A CG    1 
ATOM   761  C CD    . ARG A 1 117 ? 0.15800   38.14200  25.81300  1.000 47.02372  ? 97   ARG A CD    1 
ATOM   762  N NE    . ARG A 1 117 ? -0.98700  37.89100  24.93100  1.000 40.70529  ? 97   ARG A NE    1 
ATOM   763  C CZ    . ARG A 1 117 ? -1.24200  36.73700  24.33400  1.000 35.77491  ? 97   ARG A CZ    1 
ATOM   764  N NH1   . ARG A 1 117 ? -0.45600  35.69600  24.53700  1.000 39.12667  ? 97   ARG A NH1   1 
ATOM   765  N NH2   . ARG A 1 117 ? -2.28900  36.62700  23.53900  1.000 39.08532  ? 97   ARG A NH2   1 
ATOM   766  N N     . ARG A 1 118 ? -0.33000  41.29000  21.66000  1.000 50.73524  ? 98   ARG A N     1 
ATOM   767  C CA    . ARG A 1 118 ? -0.50000  42.63300  21.05300  1.000 53.70846  ? 98   ARG A CA    1 
ATOM   768  C C     . ARG A 1 118 ? -1.78900  43.28600  21.57100  1.000 47.01679  ? 98   ARG A C     1 
ATOM   769  O O     . ARG A 1 118 ? -2.84500  42.62300  21.57200  1.000 46.80405  ? 98   ARG A O     1 
ATOM   770  C CB    . ARG A 1 118 ? -0.48200  42.57500  19.52300  1.000 45.83900  ? 98   ARG A CB    1 
ATOM   771  C CG    . ARG A 1 118 ? -1.15200  41.39700  18.83300  1.000 53.67173  ? 98   ARG A CG    1 
ATOM   772  C CD    . ARG A 1 118 ? -0.70200  41.33900  17.38100  1.000 48.34904  ? 98   ARG A CD    1 
ATOM   773  N NE    . ARG A 1 118 ? -0.69800  42.65200  16.72700  1.000 43.80304  ? 98   ARG A NE    1 
ATOM   774  C CZ    . ARG A 1 118 ? 0.38900   43.31300  16.34800  1.000 47.35733  ? 98   ARG A CZ    1 
ATOM   775  N NH1   . ARG A 1 118 ? 1.55900   43.01600  16.88100  1.000 51.76299  ? 98   ARG A NH1   1 
ATOM   776  N NH2   . ARG A 1 118 ? 0.30500   44.27400  15.44800  1.000 43.22672  ? 98   ARG A NH2   1 
ATOM   777  N N     . SER A 1 119 ? -1.68500  44.54600  21.98000  1.000 38.61431  ? 99   SER A N     1 
ATOM   778  C CA    . SER A 1 119 ? -2.86400  45.26000  22.51700  1.000 40.60534  ? 99   SER A CA    1 
ATOM   779  C C     . SER A 1 119 ? -3.00300  46.62200  21.83700  1.000 33.34211  ? 99   SER A C     1 
ATOM   780  O O     . SER A 1 119 ? -1.97800  47.18800  21.42600  1.000 34.78229  ? 99   SER A O     1 
ATOM   781  C CB    . SER A 1 119 ? -2.77400  45.42300  24.01800  1.000 38.59158  ? 99   SER A CB    1 
ATOM   782  O OG    . SER A 1 119 ? -2.04300  46.58800  24.36400  1.000 42.69910  ? 99   SER A OG    1 
ATOM   783  N N     . LEU A 1 120 ? -4.23400  47.09800  21.72200  1.000 31.32559  ? 100  LEU A N     1 
ATOM   784  C CA    . LEU A 1 120 ? -4.47700  48.42800  21.17400  1.000 33.57535  ? 100  LEU A CA    1 
ATOM   785  C C     . LEU A 1 120 ? -4.02800  49.55400  22.09600  1.000 43.61697  ? 100  LEU A C     1 
ATOM   786  O O     . LEU A 1 120 ? -4.00200  50.71300  21.65500  1.000 44.69884  ? 100  LEU A O     1 
ATOM   787  C CB    . LEU A 1 120 ? -5.95800  48.58600  20.87700  1.000 28.61653  ? 100  LEU A CB    1 
ATOM   788  C CG    . LEU A 1 120 ? -6.45000  47.95500  19.59900  1.000 32.34270  ? 100  LEU A CG    1 
ATOM   789  C CD1   . LEU A 1 120 ? -7.94800  48.19000  19.49500  1.000 33.78332  ? 100  LEU A CD1   1 
ATOM   790  C CD2   . LEU A 1 120 ? -5.69500  48.61500  18.43300  1.000 28.48664  ? 100  LEU A CD2   1 
ATOM   791  N N     . ALA A 1 121 ? -3.68900  49.24100  23.34900  1.000 35.09376  ? 101  ALA A N     1 
ATOM   792  C CA    . ALA A 1 121 ? -3.18800  50.24300  24.28600  1.000 47.79502  ? 101  ALA A CA    1 
ATOM   793  C C     . ALA A 1 121 ? -2.04900  51.06000  23.68000  1.000 45.21587  ? 101  ALA A C     1 
ATOM   794  O O     . ALA A 1 121 ? -2.06900  52.29600  23.70400  1.000 51.49756  ? 101  ALA A O     1 
ATOM   795  C CB    . ALA A 1 121 ? -2.72100  49.55300  25.57900  1.000 41.19133  ? 101  ALA A CB    1 
ATOM   796  N N     . GLY A 1 122 ? -1.04200  50.38700  23.14100  1.000 40.43045  ? 102  GLY A N     1 
ATOM   797  C CA    . GLY A 1 122 ? 0.07000   51.10600  22.54200  1.000 54.00603  ? 102  GLY A CA    1 
ATOM   798  C C     . GLY A 1 122 ? -0.05500  51.46300  21.06600  1.000 56.14273  ? 102  GLY A C     1 
ATOM   799  O O     . GLY A 1 122 ? 0.94000   51.42600  20.33400  1.000 58.31851  ? 102  GLY A O     1 
ATOM   800  N N     . VAL A 1 123 ? -1.24900  51.82600  20.60400  1.000 54.28432  ? 103  VAL A N     1 
ATOM   801  C CA    . VAL A 1 123 ? -1.45800  52.19700  19.21000  1.000 46.98965  ? 103  VAL A CA    1 
ATOM   802  C C     . VAL A 1 123 ? -1.82000  53.66800  19.13900  1.000 43.89350  ? 103  VAL A C     1 
ATOM   803  O O     . VAL A 1 123 ? -2.76300  54.12100  19.80100  1.000 43.60602  ? 103  VAL A O     1 
ATOM   804  C CB    . VAL A 1 123 ? -2.54300  51.34100  18.53900  1.000 43.95904  ? 103  VAL A CB    1 
ATOM   805  C CG1   . VAL A 1 123 ? -2.91800  51.93800  17.20500  1.000 46.01977  ? 103  VAL A CG1   1 
ATOM   806  C CG2   . VAL A 1 123 ? -2.03800  49.94100  18.33300  1.000 46.02732  ? 103  VAL A CG2   1 
ATOM   807  N N     . THR A 1 124 ? -1.08800  54.41000  18.31400  1.000 46.57848  ? 104  THR A N     1 
ATOM   808  C CA    . THR A 1 124 ? -1.46600  55.77700  17.99900  1.000 45.48703  ? 104  THR A CA    1 
ATOM   809  C C     . THR A 1 124 ? -1.54600  55.94200  16.49300  1.000 42.75323  ? 104  THR A C     1 
ATOM   810  O O     . THR A 1 124 ? -0.72300  55.40800  15.74200  1.000 42.31938  ? 104  THR A O     1 
ATOM   811  C CB    . THR A 1 124 ? -0.48700  56.81100  18.58100  1.000 46.04544  ? 104  THR A CB    1 
ATOM   812  O OG1   . THR A 1 124 ? 0.82300   56.54800  18.07900  1.000 47.40956  ? 104  THR A OG1   1 
ATOM   813  C CG2   . THR A 1 124 ? -0.48600  56.72900  20.08800  1.000 47.64585  ? 104  THR A CG2   1 
ATOM   814  N N     . LEU A 1 125 ? -2.53900  56.69900  16.06400  1.000 42.20362  ? 105  LEU A N     1 
ATOM   815  C CA    . LEU A 1 125 ? -2.76400  56.93900  14.65700  1.000 43.14311  ? 105  LEU A CA    1 
ATOM   816  C C     . LEU A 1 125 ? -2.40400  58.38800  14.35300  1.000 43.03931  ? 105  LEU A C     1 
ATOM   817  O O     . LEU A 1 125 ? -2.46800  59.25500  15.23200  1.000 41.76817  ? 105  LEU A O     1 
ATOM   818  C CB    . LEU A 1 125 ? -4.22300  56.63900  14.28300  1.000 37.40309  ? 105  LEU A CB    1 
ATOM   819  C CG    . LEU A 1 125 ? -4.63200  55.18700  14.61400  1.000 36.78774  ? 105  LEU A CG    1 
ATOM   820  C CD1   . LEU A 1 125 ? -6.11200  54.96900  14.31800  1.000 34.61478  ? 105  LEU A CD1   1 
ATOM   821  C CD2   . LEU A 1 125 ? -3.75900  54.14800  13.88100  1.000 39.11088  ? 105  LEU A CD2   1 
ATOM   822  N N     . GLY A 1 126 ? -1.99500  58.62600  13.10800  1.000 40.30480  ? 106  GLY A N     1 
ATOM   823  C CA    . GLY A 1 126 ? -1.72400  59.96400  12.62900  1.000 37.08807  ? 106  GLY A CA    1 
ATOM   824  C C     . GLY A 1 126 ? -2.99900  60.65300  12.22400  1.000 39.96496  ? 106  GLY A C     1 
ATOM   825  O O     . GLY A 1 126 ? -4.10000  60.27800  12.63000  1.000 35.95464  ? 106  GLY A O     1 
ATOM   826  N N     . ALA A 1 127 ? -2.84500  61.66600  11.37000  1.000 35.24201  ? 107  ALA A N     1 
ATOM   827  C CA    . ALA A 1 127 ? -3.93800  62.59600  11.13500  1.000 41.87056  ? 107  ALA A CA    1 
ATOM   828  C C     . ALA A 1 127 ? -5.05200  61.99200  10.28000  1.000 41.49917  ? 107  ALA A C     1 
ATOM   829  O O     . ALA A 1 127 ? -6.24300  62.24400  10.53000  1.000 41.69670  ? 107  ALA A O     1 
ATOM   830  C CB    . ALA A 1 127 ? -3.38800  63.87300  10.49100  1.000 40.19260  ? 107  ALA A CB    1 
ATOM   831  N N     . ALA A 1 128 ? -4.70800  61.21300  9.26400   1.000 35.10143  ? 108  ALA A N     1 
ATOM   832  C CA    . ALA A 1 128 ? -5.70400  60.72100  8.31500   1.000 37.18002  ? 108  ALA A CA    1 
ATOM   833  C C     . ALA A 1 128 ? -5.46500  59.23300  8.07900   1.000 35.87190  ? 108  ALA A C     1 
ATOM   834  O O     . ALA A 1 128 ? -5.07900  58.82100  6.98000   1.000 32.61879  ? 108  ALA A O     1 
ATOM   835  C CB    . ALA A 1 128 ? -5.64400  61.51300  7.00300   1.000 36.28018  ? 108  ALA A CB    1 
ATOM   836  N N     . PRO A 1 129 ? -5.67900  58.39800  9.09700   1.000 31.67049  ? 109  PRO A N     1 
ATOM   837  C CA    . PRO A 1 129 ? -5.36600  56.97200  8.96200   1.000 30.35404  ? 109  PRO A CA    1 
ATOM   838  C C     . PRO A 1 129 ? -6.37300  56.27100  8.04400   1.000 27.99223  ? 109  PRO A C     1 
ATOM   839  O O     . PRO A 1 129 ? -7.49300  56.73100  7.81600   1.000 30.73649  ? 109  PRO A O     1 
ATOM   840  C CB    . PRO A 1 129 ? -5.47600  56.45700  10.40300  1.000 35.00107  ? 109  PRO A CB    1 
ATOM   841  C CG    . PRO A 1 129 ? -6.59400  57.29700  10.95000  1.000 33.87083  ? 109  PRO A CG    1 
ATOM   842  C CD    . PRO A 1 129 ? -6.38300  58.68700  10.36100  1.000 36.55177  ? 109  PRO A CD    1 
ATOM   843  N N     . LEU A 1 130 ? -5.94200  55.11600  7.54200   1.000 28.18239  ? 110  LEU A N     1 
ATOM   844  C CA    . LEU A 1 130 ? -6.80100  54.25900  6.68700   1.000 25.13789  ? 110  LEU A CA    1 
ATOM   845  C C     . LEU A 1 130 ? -7.02900  52.96700  7.48100   1.000 22.25849  ? 110  LEU A C     1 
ATOM   846  O O     . LEU A 1 130 ? -6.06400  52.24300  7.70400   1.000 21.57454  ? 110  LEU A O     1 
ATOM   847  C CB    . LEU A 1 130 ? -6.11400  53.99100  5.35500   1.000 24.43545  ? 110  LEU A CB    1 
ATOM   848  C CG    . LEU A 1 130 ? -6.76500  52.96100  4.43000   1.000 24.66834  ? 110  LEU A CG    1 
ATOM   849  C CD1   . LEU A 1 130 ? -8.17300  53.38000  4.07500   1.000 25.10019  ? 110  LEU A CD1   1 
ATOM   850  C CD2   . LEU A 1 130 ? -5.91500  52.83500  3.18200   1.000 29.30267  ? 110  LEU A CD2   1 
ATOM   851  N N     . VAL A 1 131 ? -8.27100  52.71400  7.87400   1.000 23.83463  ? 111  VAL A N     1 
ATOM   852  C CA    . VAL A 1 131 ? -8.52700  51.56500  8.78800   1.000 23.56220  ? 111  VAL A CA    1 
ATOM   853  C C     . VAL A 1 131 ? -9.54500  50.57300  8.21500   1.000 22.42787  ? 111  VAL A C     1 
ATOM   854  O O     . VAL A 1 131 ? -10.47500 51.00700  7.54300   1.000 25.18182  ? 111  VAL A O     1 
ATOM   855  C CB    . VAL A 1 131 ? -8.99400  52.11100  10.15500  1.000 24.36572  ? 111  VAL A CB    1 
ATOM   856  C CG1   . VAL A 1 131 ? -9.32500  51.01300  11.15700  1.000 22.60564  ? 111  VAL A CG1   1 
ATOM   857  C CG2   . VAL A 1 131 ? -7.99200  53.09000  10.75100  1.000 25.35468  ? 111  VAL A CG2   1 
ATOM   858  N N     . LEU A 1 132 ? -9.33000  49.29600  8.48800   1.000 23.57660  ? 112  LEU A N     1 
ATOM   859  C CA    . LEU A 1 132 ? -10.29400 48.25000  8.09400   1.000 25.23596  ? 112  LEU A CA    1 
ATOM   860  C C     . LEU A 1 132 ? -10.85300 47.62300  9.37500   1.000 24.44111  ? 112  LEU A C     1 
ATOM   861  O O     . LEU A 1 132 ? -10.05900 47.35300  10.28000  1.000 24.62498  ? 112  LEU A O     1 
ATOM   862  C CB    . LEU A 1 132 ? -9.67500  47.13400  7.25900   1.000 27.09316  ? 112  LEU A CB    1 
ATOM   863  C CG    . LEU A 1 132 ? -9.37200  47.40700  5.78900   1.000 31.05149  ? 112  LEU A CG    1 
ATOM   864  C CD1   . LEU A 1 132 ? -8.93400  46.06000  5.24800   1.000 27.90929  ? 112  LEU A CD1   1 
ATOM   865  C CD2   . LEU A 1 132 ? -10.60200 47.89800  5.06100   1.000 31.12735  ? 112  LEU A CD2   1 
ATOM   866  N N     . VAL A 1 133 ? -12.16300 47.43900  9.42400   1.000 23.02449  ? 113  VAL A N     1 
ATOM   867  C CA    . VAL A 1 133 ? -12.80100 46.72200  10.56100  1.000 21.69711  ? 113  VAL A CA    1 
ATOM   868  C C     . VAL A 1 133 ? -13.51600 45.50700  9.95000   1.000 23.24527  ? 113  VAL A C     1 
ATOM   869  O O     . VAL A 1 133 ? -14.41600 45.70000  9.14000   1.000 22.17698  ? 113  VAL A O     1 
ATOM   870  C CB    . VAL A 1 133 ? -13.75600 47.55400  11.43100  1.000 22.67570  ? 113  VAL A CB    1 
ATOM   871  C CG1   . VAL A 1 133 ? -14.27000 46.76300  12.62300  1.000 26.85684  ? 113  VAL A CG1   1 
ATOM   872  C CG2   . VAL A 1 133 ? -13.10400 48.85700  11.87500  1.000 24.42187  ? 113  VAL A CG2   1 
ATOM   873  N N     . LEU A 1 134 ? -13.07300 44.32100  10.32300  1.000 20.66585  ? 114  LEU A N     1 
ATOM   874  C CA    . LEU A 1 134 ? -13.65000 43.06900  9.79100   1.000 20.19264  ? 114  LEU A CA    1 
ATOM   875  C C     . LEU A 1 134 ? -14.54500 42.45600  10.87200  1.000 28.10597  ? 114  LEU A C     1 
ATOM   876  O O     . LEU A 1 134 ? -14.03600 42.08700  11.93000  1.000 26.05019  ? 114  LEU A O     1 
ATOM   877  C CB    . LEU A 1 134 ? -12.51200 42.14700  9.37000   1.000 25.68602  ? 114  LEU A CB    1 
ATOM   878  C CG    . LEU A 1 134 ? -11.38800 42.80300  8.56500   1.000 22.34629  ? 114  LEU A CG    1 
ATOM   879  C CD1   . LEU A 1 134 ? -10.29200 41.79800  8.28700   1.000 21.95285  ? 114  LEU A CD1   1 
ATOM   880  C CD2   . LEU A 1 134 ? -11.94700 43.35500  7.27100   1.000 23.00263  ? 114  LEU A CD2   1 
ATOM   881  N N     . LEU A 1 135 ? -15.81600 42.29400  10.55800  1.000 23.02183  ? 115  LEU A N     1 
ATOM   882  C CA    . LEU A 1 135 ? -16.79200 41.83500  11.54100  1.000 30.43437  ? 115  LEU A CA    1 
ATOM   883  C C     . LEU A 1 135 ? -17.27300 40.42400  11.21800  1.000 31.49261  ? 115  LEU A C     1 
ATOM   884  O O     . LEU A 1 135 ? -18.04700 40.23400  10.27300  1.000 28.38763  ? 115  LEU A O     1 
ATOM   885  C CB    . LEU A 1 135 ? -17.97400 42.80000  11.58600  1.000 28.17123  ? 115  LEU A CB    1 
ATOM   886  C CG    . LEU A 1 135 ? -17.54500 43.99900  12.40800  1.000 32.67276  ? 115  LEU A CG    1 
ATOM   887  C CD1   . LEU A 1 135 ? -18.14400 45.30200  11.87800  1.000 41.71889  ? 115  LEU A CD1   1 
ATOM   888  C CD2   . LEU A 1 135 ? -17.94500 43.73200  13.85000  1.000 42.57682  ? 115  LEU A CD2   1 
ATOM   889  N N     . GLY A 1 136 ? -16.89400 39.43700  12.03500  1.000 30.98235  ? 116  GLY A N     1 
ATOM   890  C CA    . GLY A 1 136 ? -17.45300 38.07600  11.91000  1.000 29.33273  ? 116  GLY A CA    1 
ATOM   891  C C     . GLY A 1 136 ? -17.04200 37.29800  10.68100  1.000 33.70874  ? 116  GLY A C     1 
ATOM   892  O O     . GLY A 1 136 ? -17.80000 36.41700  10.26300  1.000 35.33983  ? 116  GLY A O     1 
ATOM   893  N N     . LEU A 1 137 ? -15.86200 37.57200  10.14400  1.000 29.40726  ? 117  LEU A N     1 
ATOM   894  C CA    . LEU A 1 137 ? -15.37700 36.77700  8.98900   1.000 29.41893  ? 117  LEU A CA    1 
ATOM   895  C C     . LEU A 1 137 ? -15.03000 35.35300  9.46100   1.000 31.53991  ? 117  LEU A C     1 
ATOM   896  O O     . LEU A 1 137 ? -14.46900 35.21600  10.54400  1.000 30.21202  ? 117  LEU A O     1 
ATOM   897  C CB    . LEU A 1 137 ? -14.20800 37.49400  8.32400   1.000 27.91015  ? 117  LEU A CB    1 
ATOM   898  C CG    . LEU A 1 137 ? -14.57600 38.55800  7.28800   1.000 31.14298  ? 117  LEU A CG    1 
ATOM   899  C CD1   . LEU A 1 137 ? -15.34000 39.73500  7.86500   1.000 32.04388  ? 117  LEU A CD1   1 
ATOM   900  C CD2   . LEU A 1 137 ? -13.28400 39.02500  6.67900   1.000 29.23642  ? 117  LEU A CD2   1 
ATOM   901  N N     . GLU A 1 138 ? -15.35200 34.34400  8.66200   1.000 29.24641  ? 118  GLU A N     1 
ATOM   902  C CA    . GLU A 1 138 ? -15.16500 32.94700  9.12000   1.000 32.11747  ? 118  GLU A CA    1 
ATOM   903  C C     . GLU A 1 138 ? -14.13300 32.18700  8.28500   1.000 32.30016  ? 118  GLU A C     1 
ATOM   904  O O     . GLU A 1 138 ? -13.61600 31.19500  8.78500   1.000 32.42403  ? 118  GLU A O     1 
ATOM   905  C CB    . GLU A 1 138 ? -16.50100 32.22000  9.02500   1.000 33.36207  ? 118  GLU A CB    1 
ATOM   906  C CG    . GLU A 1 138 ? -17.50500 32.68900  10.07000  1.000 44.81181  ? 118  GLU A CG    1 
ATOM   907  C CD    . GLU A 1 138 ? -18.63500 31.72500  10.38000  1.000 51.74815  ? 118  GLU A CD    1 
ATOM   908  O OE1   . GLU A 1 138 ? -19.49500 32.11200  11.19400  1.000 52.37116  ? 118  GLU A OE1   1 
ATOM   909  O OE2   . GLU A 1 138 ? -18.66600 30.61300  9.81900   1.000 43.54870  ? 118  GLU A OE2   1 
ATOM   910  N N     . LYS A 1 139 ? -13.87300 32.62700  7.06100   1.000 27.64028  ? 119  LYS A N     1 
ATOM   911  C CA    . LYS A 1 139 ? -12.96400 31.84000  6.19900   1.000 30.43273  ? 119  LYS A CA    1 
ATOM   912  C C     . LYS A 1 139 ? -11.53500 32.38400  6.33600   1.000 28.75313  ? 119  LYS A C     1 
ATOM   913  O O     . LYS A 1 139 ? -11.27600 33.53300  5.95800   1.000 26.35195  ? 119  LYS A O     1 
ATOM   914  C CB    . LYS A 1 139 ? -13.49300 31.78300  4.76800   1.000 28.13416  ? 119  LYS A CB    1 
ATOM   915  C CG    . LYS A 1 139 ? -14.91500 31.26400  4.67700   1.000 29.63312  ? 119  LYS A CG    1 
ATOM   916  C CD    . LYS A 1 139 ? -15.38900 31.04200  3.24900   1.000 28.29519  ? 119  LYS A CD    1 
ATOM   917  C CE    . LYS A 1 139 ? -16.78800 30.53500  3.22500   1.000 28.87918  ? 119  LYS A CE    1 
ATOM   918  N NZ    . LYS A 1 139 ? -16.85600 29.12000  3.59000   1.000 30.34709  ? 119  LYS A NZ    1 
ATOM   919  N N     . PRO A 1 140 ? -10.61300 31.56300  6.86400   1.000 32.20322  ? 120  PRO A N     1 
ATOM   920  C CA    . PRO A 1 140 ? -9.25300  32.02000  7.08500   1.000 30.73426  ? 120  PRO A CA    1 
ATOM   921  C C     . PRO A 1 140 ? -8.58700  32.48300  5.78700   1.000 30.00428  ? 120  PRO A C     1 
ATOM   922  O O     . PRO A 1 140 ? -7.77800  33.41400  5.82100   1.000 28.15669  ? 120  PRO A O     1 
ATOM   923  C CB    . PRO A 1 140 ? -8.58800  30.78400  7.72000   1.000 30.35781  ? 120  PRO A CB    1 
ATOM   924  C CG    . PRO A 1 140 ? -9.45000  29.62200  7.30500   1.000 33.16114  ? 120  PRO A CG    1 
ATOM   925  C CD    . PRO A 1 140 ? -10.85000 30.18600  7.23800   1.000 33.58975  ? 120  PRO A CD    1 
ATOM   926  N N     . GLY A 1 141 ? -8.96600  31.87100  4.66400   1.000 30.28745  ? 121  GLY A N     1 
ATOM   927  C CA    . GLY A 1 141 ? -8.40300  32.31500  3.39600   1.000 25.87749  ? 121  GLY A CA    1 
ATOM   928  C C     . GLY A 1 141 ? -8.79900  33.73900  3.06800   1.000 28.58565  ? 121  GLY A C     1 
ATOM   929  O O     . GLY A 1 141 ? -7.98800  34.53000  2.55500   1.000 25.05376  ? 121  GLY A O     1 
ATOM   930  N N     . ASN A 1 142 ? -10.05400 34.09100  3.36300   1.000 24.83663  ? 122  ASN A N     1 
ATOM   931  C CA    . ASN A 1 142 ? -10.49500 35.45200  3.15700   1.000 25.07018  ? 122  ASN A CA    1 
ATOM   932  C C     . ASN A 1 142 ? -9.71200  36.41700  4.04100   1.000 23.32335  ? 122  ASN A C     1 
ATOM   933  O O     . ASN A 1 142 ? -9.27800  37.47200  3.57200   1.000 22.58591  ? 122  ASN A O     1 
ATOM   934  C CB    . ASN A 1 142 ? -12.00100 35.55000  3.39800   1.000 22.58325  ? 122  ASN A CB    1 
ATOM   935  C CG    . ASN A 1 142 ? -12.82300 34.95500  2.25900   1.000 26.26930  ? 122  ASN A CG    1 
ATOM   936  O OD1   . ASN A 1 142 ? -12.35800 34.83200  1.12100   1.000 24.87820  ? 122  ASN A OD1   1 
ATOM   937  N ND2   . ASN A 1 142 ? -14.08600 34.62500  2.55300   1.000 25.92952  ? 122  ASN A ND2   1 
ATOM   938  N N     . LEU A 1 143 ? -9.49200  36.06600  5.30300   1.000 22.10544  ? 123  LEU A N     1 
ATOM   939  C CA    . LEU A 1 143 ? -8.77200  36.96100  6.24500   1.000 26.09713  ? 123  LEU A CA    1 
ATOM   940  C C     . LEU A 1 143 ? -7.34100  37.17500  5.72800   1.000 22.25315  ? 123  LEU A C     1 
ATOM   941  O O     . LEU A 1 143 ? -6.88400  38.31000  5.68100   1.000 24.48143  ? 123  LEU A O     1 
ATOM   942  C CB    . LEU A 1 143 ? -8.76400  36.39000  7.66100   1.000 24.83089  ? 123  LEU A CB    1 
ATOM   943  C CG    . LEU A 1 143 ? -8.04300  37.21800  8.72900   1.000 24.63533  ? 123  LEU A CG    1 
ATOM   944  C CD1   . LEU A 1 143 ? -8.49900  38.65800  8.71300   1.000 22.24709  ? 123  LEU A CD1   1 
ATOM   945  C CD2   . LEU A 1 143 ? -8.24600  36.61400  10.10700  1.000 27.84260  ? 123  LEU A CD2   1 
ATOM   946  N N     . GLY A 1 144 ? -6.68300  36.09000  5.36100   1.000 22.06330  ? 124  GLY A N     1 
ATOM   947  C CA    . GLY A 1 144 ? -5.34100  36.19700  4.80300   1.000 25.24101  ? 124  GLY A CA    1 
ATOM   948  C C     . GLY A 1 144 ? -5.27500  37.03300  3.53800   1.000 26.75766  ? 124  GLY A C     1 
ATOM   949  O O     . GLY A 1 144 ? -4.36800  37.85800  3.39000   1.000 22.96377  ? 124  GLY A O     1 
ATOM   950  N N     . ALA A 1 145 ? -6.26200  36.88000  2.62200   1.000 21.88088  ? 125  ALA A N     1 
ATOM   951  C CA    . ALA A 1 145 ? -6.22500  37.72300  1.43100   1.000 20.46661  ? 125  ALA A CA    1 
ATOM   952  C C     . ALA A 1 145 ? -6.42200  39.18800  1.79100   1.000 22.44580  ? 125  ALA A C     1 
ATOM   953  O O     . ALA A 1 145 ? -5.75500  40.07000  1.22500   1.000 21.97261  ? 125  ALA A O     1 
ATOM   954  C CB    . ALA A 1 145 ? -7.26600  37.25700  0.39800   1.000 22.82373  ? 125  ALA A CB    1 
ATOM   955  N N     . ILE A 1 146 ? -7.26600  39.47100  2.77800   1.000 20.57084  ? 126  ILE A N     1 
ATOM   956  C CA    . ILE A 1 146 ? -7.49100  40.88200  3.22300   1.000 21.08640  ? 126  ILE A CA    1 
ATOM   957  C C     . ILE A 1 146 ? -6.18100  41.45900  3.78000   1.000 23.61716  ? 126  ILE A C     1 
ATOM   958  O O     . ILE A 1 146 ? -5.82600  42.57800  3.41700   1.000 24.75405  ? 126  ILE A O     1 
ATOM   959  C CB    . ILE A 1 146 ? -8.62800  40.98000  4.25300   1.000 22.59571  ? 126  ILE A CB    1 
ATOM   960  C CG1   . ILE A 1 146 ? -9.96400  40.73200  3.58600   1.000 23.12750  ? 126  ILE A CG1   1 
ATOM   961  C CG2   . ILE A 1 146 ? -8.60700  42.32100  4.98000   1.000 25.33365  ? 126  ILE A CG2   1 
ATOM   962  C CD1   . ILE A 1 146 ? -11.02800 40.19200  4.51100   1.000 24.74357  ? 126  ILE A CD1   1 
ATOM   963  N N     . LEU A 1 147 ? -5.51400  40.69400  4.62800   1.000 23.37756  ? 127  LEU A N     1 
ATOM   964  C CA    . LEU A 1 147 ? -4.27000  41.19900  5.20800   1.000 27.86155  ? 127  LEU A CA    1 
ATOM   965  C C     . LEU A 1 147 ? -3.23000  41.45600  4.12200   1.000 24.84254  ? 127  LEU A C     1 
ATOM   966  O O     . LEU A 1 147 ? -2.50000  42.44700  4.17700   1.000 26.79309  ? 127  LEU A O     1 
ATOM   967  C CB    . LEU A 1 147 ? -3.72800  40.20000  6.24500   1.000 26.88858  ? 127  LEU A CB    1 
ATOM   968  C CG    . LEU A 1 147 ? -4.67900  39.94300  7.43500   1.000 25.96687  ? 127  LEU A CG    1 
ATOM   969  C CD1   . LEU A 1 147 ? -4.06800  38.98400  8.53700   1.000 24.79777  ? 127  LEU A CD1   1 
ATOM   970  C CD2   . LEU A 1 147 ? -5.15900  41.24700  8.04500   1.000 26.03489  ? 127  LEU A CD2   1 
ATOM   971  N N     . ARG A 1 148 ? -3.13900  40.56400  3.14200   1.000 21.29991  ? 128  ARG A N     1 
ATOM   972  C CA    . ARG A 1 148 ? -2.28300  40.81800  1.98900   1.000 26.73255  ? 128  ARG A CA    1 
ATOM   973  C C     . ARG A 1 148 ? -2.67500  42.09800  1.24700   1.000 25.28627  ? 128  ARG A C     1 
ATOM   974  O O     . ARG A 1 148 ? -1.81100  42.90000  0.88200   1.000 23.60569  ? 128  ARG A O     1 
ATOM   975  C CB    . ARG A 1 148 ? -2.33200  39.61700  1.08400   1.000 25.84822  ? 128  ARG A CB    1 
ATOM   976  C CG    . ARG A 1 148 ? -1.39400  39.63000  -0.08200  1.000 31.47451  ? 128  ARG A CG    1 
ATOM   977  C CD    . ARG A 1 148 ? -1.23100  38.17900  -0.49000  1.000 33.75426  ? 128  ARG A CD    1 
ATOM   978  N NE    . ARG A 1 148 ? -0.49200  38.05200  -1.72400  1.000 37.07342  ? 128  ARG A NE    1 
ATOM   979  C CZ    . ARG A 1 148 ? -0.41100  36.92800  -2.42100  1.000 39.48400  ? 128  ARG A CZ    1 
ATOM   980  N NH1   . ARG A 1 148 ? -1.02700  35.82800  -1.99000  1.000 37.23147  ? 128  ARG A NH1   1 
ATOM   981  N NH2   . ARG A 1 148 ? 0.29400   36.90700  -3.54600  1.000 40.65467  ? 128  ARG A NH2   1 
ATOM   982  N N     . ALA A 1 149 ? -3.97000  42.34100  1.02600   1.000 22.81394  ? 129  ALA A N     1 
ATOM   983  C CA    . ALA A 1 149 ? -4.34600  43.62100  0.43000   1.000 21.79887  ? 129  ALA A CA    1 
ATOM   984  C C     . ALA A 1 149 ? -4.05700  44.80800  1.34800   1.000 22.73652  ? 129  ALA A C     1 
ATOM   985  O O     . ALA A 1 149 ? -3.78300  45.92100  0.87000   1.000 23.56222  ? 129  ALA A O     1 
ATOM   986  C CB    . ALA A 1 149 ? -5.83100  43.60400  0.06000   1.000 17.65687  ? 129  ALA A CB    1 
ATOM   987  N N     . ALA A 1 150 ? -4.22900  44.64700  2.65100   1.000 23.62197  ? 130  ALA A N     1 
ATOM   988  C CA    . ALA A 1 150 ? -4.01800  45.78300  3.58000   1.000 24.48935  ? 130  ALA A CA    1 
ATOM   989  C C     . ALA A 1 150 ? -2.54600  46.17000  3.53200   1.000 23.28701  ? 130  ALA A C     1 
ATOM   990  O O     . ALA A 1 150 ? -2.21500  47.35000  3.63000   1.000 22.01734  ? 130  ALA A O     1 
ATOM   991  C CB    . ALA A 1 150 ? -4.42600  45.38500  4.96200   1.000 25.00278  ? 130  ALA A CB    1 
ATOM   992  N N     . ASP A 1 151 ? -1.70600  45.15800  3.45300   1.000 22.67259  ? 131  ASP A N     1 
ATOM   993  C CA    . ASP A 1 151 ? -0.26800  45.35000  3.31100   1.000 27.47309  ? 131  ASP A CA    1 
ATOM   994  C C     . ASP A 1 151 ? 0.05000   46.09600  2.01100   1.000 26.98435  ? 131  ASP A C     1 
ATOM   995  O O     . ASP A 1 151 ? 0.74300   47.13400  2.02500   1.000 29.32382  ? 131  ASP A O     1 
ATOM   996  C CB    . ASP A 1 151 ? 0.37400   43.95100  3.35600   1.000 24.66491  ? 131  ASP A CB    1 
ATOM   997  C CG    . ASP A 1 151 ? 1.88400   43.96800  3.20100   1.000 38.53747  ? 131  ASP A CG    1 
ATOM   998  O OD1   . ASP A 1 151 ? 2.60400   44.07000  4.22300   1.000 41.46323  ? 131  ASP A OD1   1 
ATOM   999  O OD2   . ASP A 1 151 ? 2.34900   43.87700  2.05200   1.000 39.72825  ? 131  ASP A OD2   1 
ATOM   1000 N N     . GLY A 1 152 ? -0.49700  45.62300  0.88100   1.000 27.90277  ? 132  GLY A N     1 
ATOM   1001 C CA    . GLY A 1 152 ? -0.27600  46.32300  -0.39700  1.000 24.68085  ? 132  GLY A CA    1 
ATOM   1002 C C     . GLY A 1 152 ? -0.70500  47.78000  -0.35800  1.000 27.05013  ? 132  GLY A C     1 
ATOM   1003 O O     . GLY A 1 152 ? 0.02200   48.67700  -0.81200  1.000 25.67654  ? 132  GLY A O     1 
ATOM   1004 N N     . ALA A 1 153 ? -1.89100  48.04300  0.21400   1.000 26.70164  ? 133  ALA A N     1 
ATOM   1005 C CA    . ALA A 1 153 ? -2.46300  49.37000  0.23600   1.000 25.47782  ? 133  ALA A CA    1 
ATOM   1006 C C     . ALA A 1 153 ? -1.90100  50.24700  1.34400   1.000 23.75785  ? 133  ALA A C     1 
ATOM   1007 O O     . ALA A 1 153 ? -2.18400  51.45100  1.35500   1.000 27.78590  ? 133  ALA A O     1 
ATOM   1008 C CB    . ALA A 1 153 ? -3.99100  49.29200  0.40600   1.000 26.03440  ? 133  ALA A CB    1 
ATOM   1009 N N     . GLY A 1 154 ? -1.10900  49.69700  2.24800   1.000 26.52939  ? 134  GLY A N     1 
ATOM   1010 C CA    . GLY A 1 154 ? -0.59500  50.48300  3.37200   1.000 27.59054  ? 134  GLY A CA    1 
ATOM   1011 C C     . GLY A 1 154 ? -1.61600  50.86100  4.43200   1.000 27.80527  ? 134  GLY A C     1 
ATOM   1012 O O     . GLY A 1 154 ? -1.55600  51.97400  4.96500   1.000 27.59631  ? 134  GLY A O     1 
ATOM   1013 N N     . ALA A 1 155 ? -2.56200  49.96700  4.75800   1.000 25.92163  ? 135  ALA A N     1 
ATOM   1014 C CA    . ALA A 1 155 ? -3.52100  50.28200  5.81900   1.000 26.87979  ? 135  ALA A CA    1 
ATOM   1015 C C     . ALA A 1 155 ? -2.81400  50.60400  7.14900   1.000 23.92258  ? 135  ALA A C     1 
ATOM   1016 O O     . ALA A 1 155 ? -1.82500  49.96800  7.51900   1.000 28.47926  ? 135  ALA A O     1 
ATOM   1017 C CB    . ALA A 1 155 ? -4.49200  49.10500  6.01500   1.000 24.07585  ? 135  ALA A CB    1 
ATOM   1018 N N     . ASP A 1 156 ? -3.33400  51.58000  7.89200   1.000 24.35399  ? 136  ASP A N     1 
ATOM   1019 C CA    . ASP A 1 156 ? -2.68700  51.89600  9.17400   1.000 27.80511  ? 136  ASP A CA    1 
ATOM   1020 C C     . ASP A 1 156 ? -3.13500  50.97600  10.31200  1.000 28.33019  ? 136  ASP A C     1 
ATOM   1021 O O     . ASP A 1 156 ? -2.41100  50.84300  11.30500  1.000 29.29260  ? 136  ASP A O     1 
ATOM   1022 C CB    . ASP A 1 156 ? -2.95500  53.35900  9.52800   1.000 29.34665  ? 136  ASP A CB    1 
ATOM   1023 C CG    . ASP A 1 156 ? -2.32800  54.29200  8.51300   1.000 29.25412  ? 136  ASP A CG    1 
ATOM   1024 O OD1   . ASP A 1 156 ? -1.08700  54.35800  8.50100   1.000 35.37228  ? 136  ASP A OD1   1 
ATOM   1025 O OD2   . ASP A 1 156 ? -3.06500  54.83900  7.68200   1.000 30.27433  ? 136  ASP A OD2   1 
ATOM   1026 N N     . LEU A 1 157 ? -4.28300  50.33100  10.14200  1.000 25.18327  ? 137  LEU A N     1 
ATOM   1027 C CA    . LEU A 1 157 ? -4.81600  49.46400  11.21500  1.000 24.67277  ? 137  LEU A CA    1 
ATOM   1028 C C     . LEU A 1 157 ? -5.86500  48.48900  10.67300  1.000 22.59065  ? 137  LEU A C     1 
ATOM   1029 O O     . LEU A 1 157 ? -6.67000  48.90300  9.84300   1.000 25.05449  ? 137  LEU A O     1 
ATOM   1030 C CB    . LEU A 1 157 ? -5.41000  50.31800  12.32900  1.000 23.71273  ? 137  LEU A CB    1 
ATOM   1031 C CG    . LEU A 1 157 ? -5.88100  49.57500  13.58000  1.000 25.01609  ? 137  LEU A CG    1 
ATOM   1032 C CD1   . LEU A 1 157 ? -4.67800  49.12000  14.36600  1.000 27.61427  ? 137  LEU A CD1   1 
ATOM   1033 C CD2   . LEU A 1 157 ? -6.72500  50.51000  14.41300  1.000 29.06568  ? 137  LEU A CD2   1 
ATOM   1034 N N     . VAL A 1 158 ? -5.80700  47.25100  11.14700  1.000 20.90232  ? 138  VAL A N     1 
ATOM   1035 C CA    . VAL A 1 158 ? -6.84900  46.25300  10.79900  1.000 22.50045  ? 138  VAL A CA    1 
ATOM   1036 C C     . VAL A 1 158 ? -7.42200  45.70100  12.11900  1.000 23.19733  ? 138  VAL A C     1 
ATOM   1037 O O     . VAL A 1 158 ? -6.67200  45.07400  12.86100  1.000 22.45532  ? 138  VAL A O     1 
ATOM   1038 C CB    . VAL A 1 158 ? -6.38000  45.09800  9.89900   1.000 21.28923  ? 138  VAL A CB    1 
ATOM   1039 C CG1   . VAL A 1 158 ? -7.51500  44.13900  9.57700   1.000 19.19525  ? 138  VAL A CG1   1 
ATOM   1040 C CG2   . VAL A 1 158 ? -5.70400  45.60700  8.63400   1.000 21.75704  ? 138  VAL A CG2   1 
ATOM   1041 N N     . LEU A 1 159 ? -8.70000  45.95200  12.37000  1.000 22.21446  ? 139  LEU A N     1 
ATOM   1042 C CA    . LEU A 1 159 ? -9.38500  45.38000  13.55300  1.000 22.58363  ? 139  LEU A CA    1 
ATOM   1043 C C     . LEU A 1 159 ? -10.16200 44.12900  13.11600  1.000 25.16708  ? 139  LEU A C     1 
ATOM   1044 O O     . LEU A 1 159 ? -10.97400 44.23100  12.20000  1.000 24.01446  ? 139  LEU A O     1 
ATOM   1045 C CB    . LEU A 1 159 ? -10.29700 46.42800  14.18100  1.000 20.58824  ? 139  LEU A CB    1 
ATOM   1046 C CG    . LEU A 1 159 ? -9.60100  47.64700  14.79200  1.000 26.10824  ? 139  LEU A CG    1 
ATOM   1047 C CD1   . LEU A 1 159 ? -10.60400 48.47800  15.56400  1.000 29.66012  ? 139  LEU A CD1   1 
ATOM   1048 C CD2   . LEU A 1 159 ? -8.45100  47.22400  15.68100  1.000 23.22126  ? 139  LEU A CD2   1 
ATOM   1049 N N     . VAL A 1 160 ? -9.84800  43.00100  13.73700  1.000 21.76939  ? 140  VAL A N     1 
ATOM   1050 C CA    . VAL A 1 160 ? -10.52400 41.71500  13.42500  1.000 22.55085  ? 140  VAL A CA    1 
ATOM   1051 C C     . VAL A 1 160 ? -11.49100 41.45300  14.58700  1.000 27.85396  ? 140  VAL A C     1 
ATOM   1052 O O     . VAL A 1 160 ? -11.04100 41.10700  15.66900  1.000 24.92292  ? 140  VAL A O     1 
ATOM   1053 C CB    . VAL A 1 160 ? -9.55500  40.54800  13.17000  1.000 25.74567  ? 140  VAL A CB    1 
ATOM   1054 C CG1   . VAL A 1 160 ? -10.29900 39.30300  12.71700  1.000 28.66546  ? 140  VAL A CG1   1 
ATOM   1055 C CG2   . VAL A 1 160 ? -8.48600  40.92700  12.15600  1.000 23.17101  ? 140  VAL A CG2   1 
ATOM   1056 N N     . ALA A 1 161 ? -12.77500 41.64900  14.33100  1.000 30.17700  ? 141  ALA A N     1 
ATOM   1057 C CA    . ALA A 1 161 ? -13.75200 41.57100  15.40500  1.000 33.00314  ? 141  ALA A CA    1 
ATOM   1058 C C     . ALA A 1 161 ? -14.43700 40.21800  15.31500  1.000 36.37496  ? 141  ALA A C     1 
ATOM   1059 O O     . ALA A 1 161 ? -15.13800 39.93800  14.33500  1.000 32.40024  ? 141  ALA A O     1 
ATOM   1060 C CB    . ALA A 1 161 ? -14.75000 42.72500  15.32100  1.000 31.34436  ? 141  ALA A CB    1 
ATOM   1061 N N     . GLU A 1 162 ? -14.18800 39.36500  16.31300  1.000 36.93906  ? 142  GLU A N     1 
ATOM   1062 C CA    . GLU A 1 162 ? -14.91800 38.09700  16.48100  1.000 35.68937  ? 142  GLU A CA    1 
ATOM   1063 C C     . GLU A 1 162 ? -14.90700 37.22700  15.21800  1.000 41.62248  ? 142  GLU A C     1 
ATOM   1064 O O     . GLU A 1 162 ? -15.91900 36.65100  14.80100  1.000 46.71525  ? 142  GLU A O     1 
ATOM   1065 C CB    . GLU A 1 162 ? -16.34800 38.36200  16.94700  1.000 42.42550  ? 142  GLU A CB    1 
ATOM   1066 C CG    . GLU A 1 162 ? -16.48200 38.32400  18.50800  1.000 42.83228  ? 142  GLU A CG    1 
ATOM   1067 C CD    . GLU A 1 162 ? -17.27600 39.49500  19.02000  1.000 49.28735  ? 142  GLU A CD    1 
ATOM   1068 O OE1   . GLU A 1 162 ? -16.87100 40.13200  20.02800  1.000 45.15544  ? 142  GLU A OE1   1 
ATOM   1069 O OE2   . GLU A 1 162 ? -18.33000 39.77600  18.39200  1.000 61.56522  ? 142  GLU A OE2   1 
ATOM   1070 N N     . GLY A 1 163 ? -13.76200 37.06200  14.61000  1.000 37.65504  ? 143  GLY A N     1 
ATOM   1071 C CA    . GLY A 1 163 ? -13.86100 36.16600  13.45300  1.000 42.96933  ? 143  GLY A CA    1 
ATOM   1072 C C     . GLY A 1 163 ? -12.98700 34.95100  13.58700  1.000 41.58978  ? 143  GLY A C     1 
ATOM   1073 O O     . GLY A 1 163 ? -12.65600 34.57400  14.71900  1.000 37.64869  ? 143  GLY A O     1 
ATOM   1074 N N     . VAL A 1 164 ? -12.64200 34.36000  12.45400  1.000 38.26146  ? 144  VAL A N     1 
ATOM   1075 C CA    . VAL A 1 164 ? -11.67000 33.24100  12.46800  1.000 36.76402  ? 144  VAL A CA    1 
ATOM   1076 C C     . VAL A 1 164 ? -10.38100 33.76300  13.11700  1.000 36.57380  ? 144  VAL A C     1 
ATOM   1077 O O     . VAL A 1 164 ? -10.10600 34.96800  13.04500  1.000 29.92371  ? 144  VAL A O     1 
ATOM   1078 C CB    . VAL A 1 164 ? -11.44200 32.67900  11.05700  1.000 33.05155  ? 144  VAL A CB    1 
ATOM   1079 C CG1   . VAL A 1 164 ? -10.75100 33.67600  10.13900  1.000 31.02907  ? 144  VAL A CG1   1 
ATOM   1080 C CG2   . VAL A 1 164 ? -10.75000 31.32400  11.06700  1.000 34.48865  ? 144  VAL A CG2   1 
ATOM   1081 N N     . ASP A 1 165 ? -9.61200  32.85900  13.69300  1.000 34.86538  ? 145  ASP A N     1 
ATOM   1082 C CA    . ASP A 1 165 ? -8.43000  33.24200  14.45200  1.000 34.38975  ? 145  ASP A CA    1 
ATOM   1083 C C     . ASP A 1 165 ? -7.31200  33.74800  13.53000  1.000 31.91169  ? 145  ASP A C     1 
ATOM   1084 O O     . ASP A 1 165 ? -7.01400  33.13900  12.50200  1.000 30.26835  ? 145  ASP A O     1 
ATOM   1085 C CB    . ASP A 1 165 ? -7.97100  32.02600  15.27400  1.000 33.26881  ? 145  ASP A CB    1 
ATOM   1086 C CG    . ASP A 1 165 ? -6.62200  32.22400  15.89700  1.000 39.18496  ? 145  ASP A CG    1 
ATOM   1087 O OD1   . ASP A 1 165 ? -6.34500  33.35100  16.35000  1.000 40.66912  ? 145  ASP A OD1   1 
ATOM   1088 O OD2   . ASP A 1 165 ? -5.84200  31.25600  15.94300  1.000 41.86421  ? 145  ASP A OD2   1 
ATOM   1089 N N     . LEU A 1 166 ? -6.66300  34.84700  13.94100  1.000 33.90749  ? 146  LEU A N     1 
ATOM   1090 C CA    . LEU A 1 166 ? -5.63600  35.53400  13.13900  1.000 33.95371  ? 146  LEU A CA    1 
ATOM   1091 C C     . LEU A 1 166 ? -4.43400  34.64800  12.80300  1.000 35.60676  ? 146  LEU A C     1 
ATOM   1092 O O     . LEU A 1 166 ? -3.80700  34.81800  11.74800  1.000 32.18379  ? 146  LEU A O     1 
ATOM   1093 C CB    . LEU A 1 166 ? -5.16000  36.76900  13.91300  1.000 35.36819  ? 146  LEU A CB    1 
ATOM   1094 C CG    . LEU A 1 166 ? -4.55300  37.94200  13.20900  1.000 39.76946  ? 146  LEU A CG    1 
ATOM   1095 C CD1   . LEU A 1 166 ? -5.50700  38.37800  12.13100  1.000 39.82625  ? 146  LEU A CD1   1 
ATOM   1096 C CD2   . LEU A 1 166 ? -4.32500  39.03600  14.21300  1.000 32.60053  ? 146  LEU A CD2   1 
ATOM   1097 N N     . PHE A 1 167 ? -4.09100  33.70200  13.67100  1.000 33.03364  ? 147  PHE A N     1 
ATOM   1098 C CA    . PHE A 1 167 ? -2.93500  32.83300  13.45100  1.000 33.06141  ? 147  PHE A CA    1 
ATOM   1099 C C     . PHE A 1 167 ? -3.31600  31.41600  12.98500  1.000 36.15792  ? 147  PHE A C     1 
ATOM   1100 O O     . PHE A 1 167 ? -2.61500  30.44600  13.27600  1.000 36.17196  ? 147  PHE A O     1 
ATOM   1101 C CB    . PHE A 1 167 ? -2.08800  32.81900  14.72000  1.000 35.33565  ? 147  PHE A CB    1 
ATOM   1102 C CG    . PHE A 1 167 ? -1.66300  34.21400  15.11800  1.000 37.58553  ? 147  PHE A CG    1 
ATOM   1103 C CD1   . PHE A 1 167 ? -0.75800  34.91100  14.32900  1.000 34.78614  ? 147  PHE A CD1   1 
ATOM   1104 C CD2   . PHE A 1 167 ? -2.24400  34.86100  16.19800  1.000 39.25798  ? 147  PHE A CD2   1 
ATOM   1105 C CE1   . PHE A 1 167 ? -0.38900  36.22800  14.63800  1.000 35.40933  ? 147  PHE A CE1   1 
ATOM   1106 C CE2   . PHE A 1 167 ? -1.87500  36.17800  16.53100  1.000 40.89719  ? 147  PHE A CE2   1 
ATOM   1107 C CZ    . PHE A 1 167 ? -0.95700  36.86300  15.72900  1.000 38.69895  ? 147  PHE A CZ    1 
ATOM   1108 N N     . SER A 1 168 ? -4.41400  31.28800  12.24600  1.000 33.50833  ? 148  SER A N     1 
ATOM   1109 C CA    . SER A 1 168 ? -4.70500  30.05000  11.54600  1.000 34.92937  ? 148  SER A CA    1 
ATOM   1110 C C     . SER A 1 168 ? -3.70000  29.84400  10.40800  1.000 34.06799  ? 148  SER A C     1 
ATOM   1111 O O     . SER A 1 168 ? -3.28800  30.80500  9.76300   1.000 35.09038  ? 148  SER A O     1 
ATOM   1112 C CB    . SER A 1 168 ? -6.10600  30.09700  10.96900  1.000 32.23151  ? 148  SER A CB    1 
ATOM   1113 O OG    . SER A 1 168 ? -7.04900  30.35200  11.99400  1.000 34.89708  ? 148  SER A OG    1 
ATOM   1114 N N     . PRO A 1 169 ? -3.33400  28.59500  10.11100  1.000 33.63640  ? 149  PRO A N     1 
ATOM   1115 C CA    . PRO A 1 169 ? -2.40300  28.35100  8.98600   1.000 33.89546  ? 149  PRO A CA    1 
ATOM   1116 C C     . PRO A 1 169 ? -2.77000  29.05500  7.68700   1.000 37.47433  ? 149  PRO A C     1 
ATOM   1117 O O     . PRO A 1 169 ? -1.87200  29.58000  7.01700   1.000 31.41525  ? 149  PRO A O     1 
ATOM   1118 C CB    . PRO A 1 169 ? -2.44900  26.82600  8.85100   1.000 34.74465  ? 149  PRO A CB    1 
ATOM   1119 C CG    . PRO A 1 169 ? -2.61700  26.36700  10.28400  1.000 35.53518  ? 149  PRO A CG    1 
ATOM   1120 C CD    . PRO A 1 169 ? -3.55400  27.36700  10.91200  1.000 39.01759  ? 149  PRO A CD    1 
ATOM   1121 N N     . GLN A 1 170 ? -4.05600  29.07100  7.29200   1.000 34.38260  ? 150  GLN A N     1 
ATOM   1122 C CA    . GLN A 1 170 ? -4.39000  29.68900  6.01300   1.000 30.87893  ? 150  GLN A CA    1 
ATOM   1123 C C     . GLN A 1 170 ? -4.31100  31.20400  6.06000   1.000 27.33800  ? 150  GLN A C     1 
ATOM   1124 O O     . GLN A 1 170 ? -4.13000  31.82100  4.99900   1.000 30.93342  ? 150  GLN A O     1 
ATOM   1125 C CB    . GLN A 1 170 ? -5.80600  29.28000  5.54700   1.000 34.32937  ? 150  GLN A CB    1 
ATOM   1126 C CG    . GLN A 1 170 ? -6.04300  27.76100  5.54400   1.000 42.85902  ? 150  GLN A CG    1 
ATOM   1127 C CD    . GLN A 1 170 ? -6.43800  27.17900  6.92300   1.000 46.59026  ? 150  GLN A CD    1 
ATOM   1128 O OE1   . GLN A 1 170 ? -6.25800  27.81000  7.98800   1.000 40.82197  ? 150  GLN A OE1   1 
ATOM   1129 N NE2   . GLN A 1 170 ? -6.97800  25.95400  6.89700   1.000 51.85471  ? 150  GLN A NE2   1 
ATOM   1130 N N     . VAL A 1 171 ? -4.50700  31.81800  7.24600   1.000 31.27282  ? 151  VAL A N     1 
ATOM   1131 C CA    . VAL A 1 171 ? -4.26200  33.24800  7.34900   1.000 29.98690  ? 151  VAL A CA    1 
ATOM   1132 C C     . VAL A 1 171 ? -2.77400  33.51300  7.13000   1.000 30.43887  ? 151  VAL A C     1 
ATOM   1133 O O     . VAL A 1 171 ? -2.39400  34.38300  6.34100   1.000 26.39681  ? 151  VAL A O     1 
ATOM   1134 C CB    . VAL A 1 171 ? -4.73900  33.82500  8.69900   1.000 31.30314  ? 151  VAL A CB    1 
ATOM   1135 C CG1   . VAL A 1 171 ? -4.48400  35.33100  8.71500   1.000 26.96444  ? 151  VAL A CG1   1 
ATOM   1136 C CG2   . VAL A 1 171 ? -6.25300  33.55300  8.96500   1.000 26.39830  ? 151  VAL A CG2   1 
ATOM   1137 N N     . ILE A 1 172 ? -1.92300  32.73300  7.78900   1.000 26.72755  ? 152  ILE A N     1 
ATOM   1138 C CA    . ILE A 1 172 ? -0.47500  32.91300  7.61900   1.000 30.27397  ? 152  ILE A CA    1 
ATOM   1139 C C     . ILE A 1 172 ? -0.07100  32.65500  6.17100   1.000 29.22866  ? 152  ILE A C     1 
ATOM   1140 O O     . ILE A 1 172 ? 0.63500   33.46000  5.55300   1.000 33.70800  ? 152  ILE A O     1 
ATOM   1141 C CB    . ILE A 1 172 ? 0.30100   31.99700  8.58300   1.000 28.05924  ? 152  ILE A CB    1 
ATOM   1142 C CG1   . ILE A 1 172 ? 0.03600   32.38500  10.03400  1.000 30.81293  ? 152  ILE A CG1   1 
ATOM   1143 C CG2   . ILE A 1 172 ? 1.80400   32.00400  8.23400   1.000 33.82285  ? 152  ILE A CG2   1 
ATOM   1144 C CD1   . ILE A 1 172 ? 0.33900   31.22100  11.04000  1.000 25.67347  ? 152  ILE A CD1   1 
ATOM   1145 N N     . ARG A 1 173 ? -0.56400  31.57000  5.58000   1.000 30.50051  ? 153  ARG A N     1 
ATOM   1146 C CA    . ARG A 1 173 ? -0.15100  31.24600  4.20800   1.000 29.12027  ? 153  ARG A CA    1 
ATOM   1147 C C     . ARG A 1 173 ? -0.68900  32.26500  3.19800   1.000 38.16147  ? 153  ARG A C     1 
ATOM   1148 O O     . ARG A 1 173 ? 0.06500   32.80400  2.36800   1.000 35.81615  ? 153  ARG A O     1 
ATOM   1149 C CB    . ARG A 1 173 ? -0.60800  29.83100  3.85000   1.000 34.81092  ? 153  ARG A CB    1 
ATOM   1150 C CG    . ARG A 1 173 ? -0.16900  29.40700  2.44100   1.000 40.29530  ? 153  ARG A CG    1 
ATOM   1151 C CD    . ARG A 1 173 ? -0.70600  28.02000  2.07700   1.000 42.92336  ? 153  ARG A CD    1 
ATOM   1152 N NE    . ARG A 1 173 ? 0.04500   27.46700  0.94800   1.000 48.99634  ? 153  ARG A NE    1 
ATOM   1153 C CZ    . ARG A 1 173 ? -0.16000  26.25800  0.42100   1.000 50.04121  ? 153  ARG A CZ    1 
ATOM   1154 N NH1   . ARG A 1 173 ? -1.09700  25.44500  0.91000   1.000 45.09713  ? 153  ARG A NH1   1 
ATOM   1155 N NH2   . ARG A 1 173 ? 0.59000   25.85000  -0.59400  1.000 53.47143  ? 153  ARG A NH2   1 
ATOM   1156 N N     . ASN A 1 174 ? -1.98500  32.58700  3.27300   1.000 33.48133  ? 154  ASN A N     1 
ATOM   1157 C CA    . ASN A 1 174 ? -2.53400  33.45300  2.23100   1.000 29.30383  ? 154  ASN A CA    1 
ATOM   1158 C C     . ASN A 1 174 ? -2.13700  34.91400  2.39300   1.000 31.94292  ? 154  ASN A C     1 
ATOM   1159 O O     . ASN A 1 174 ? -2.25000  35.67000  1.41700   1.000 34.96648  ? 154  ASN A O     1 
ATOM   1160 C CB    . ASN A 1 174 ? -4.07100  33.32400  2.17200   1.000 32.22032  ? 154  ASN A CB    1 
ATOM   1161 C CG    . ASN A 1 174 ? -4.61900  33.46800  0.74500   1.000 40.65782  ? 154  ASN A CG    1 
ATOM   1162 O OD1   . ASN A 1 174 ? -3.86100  33.38400  -0.22400  1.000 39.53306  ? 154  ASN A OD1   1 
ATOM   1163 N ND2   . ASN A 1 174 ? -5.93200  33.69500  0.61200   1.000 36.04764  ? 154  ASN A ND2   1 
ATOM   1164 N N     . SER A 1 175 ? -1.69800  35.34700  3.59300   1.000 31.78205  ? 155  SER A N     1 
ATOM   1165 C CA    . SER A 1 175 ? -1.07300  36.66800  3.71700   1.000 33.27537  ? 155  SER A CA    1 
ATOM   1166 C C     . SER A 1 175 ? 0.40300   36.64000  3.36600   1.000 34.85883  ? 155  SER A C     1 
ATOM   1167 O O     . SER A 1 175 ? 1.05000   37.68400  3.44000   1.000 35.55639  ? 155  SER A O     1 
ATOM   1168 C CB    . SER A 1 175 ? -1.20900  37.24900  5.13800   1.000 29.24726  ? 155  SER A CB    1 
ATOM   1169 O OG    . SER A 1 175 ? -0.52300  36.45200  6.09400   1.000 31.62215  ? 155  SER A OG    1 
ATOM   1170 N N     . THR A 1 176 ? 0.92700   35.47300  2.99800   1.000 38.60136  ? 156  THR A N     1 
ATOM   1171 C CA    . THR A 1 176 ? 2.34700   35.24500  2.73900   1.000 38.99511  ? 156  THR A CA    1 
ATOM   1172 C C     . THR A 1 176 ? 3.20100   35.77900  3.88900   1.000 40.77637  ? 156  THR A C     1 
ATOM   1173 O O     . THR A 1 176 ? 4.31100   36.26700  3.68000   1.000 44.88230  ? 156  THR A O     1 
ATOM   1174 C CB    . THR A 1 176 ? 2.78200   35.82000  1.37200   1.000 40.65631  ? 156  THR A CB    1 
ATOM   1175 O OG1   . THR A 1 176 ? 2.39600   37.18600  1.24100   1.000 46.87421  ? 156  THR A OG1   1 
ATOM   1176 C CG2   . THR A 1 176 ? 2.12300   35.07400  0.22400   1.000 44.77355  ? 156  THR A CG2   1 
ATOM   1177 N N     . GLY A 1 177 ? 2.68200   35.65600  5.12100   1.000 38.00528  ? 157  GLY A N     1 
ATOM   1178 C CA    . GLY A 1 177 ? 3.34400   36.08600  6.33800   1.000 36.75027  ? 157  GLY A CA    1 
ATOM   1179 C C     . GLY A 1 177 ? 3.16300   37.55200  6.69600   1.000 33.83234  ? 157  GLY A C     1 
ATOM   1180 O O     . GLY A 1 177 ? 3.70500   37.99200  7.71400   1.000 37.26679  ? 157  GLY A O     1 
ATOM   1181 N N     . ALA A 1 178 ? 2.40600   38.31600  5.91400   1.000 34.50964  ? 158  ALA A N     1 
ATOM   1182 C CA    . ALA A 1 178 ? 2.16700   39.70900  6.26200   1.000 35.29538  ? 158  ALA A CA    1 
ATOM   1183 C C     . ALA A 1 178 ? 1.42200   39.85300  7.58500   1.000 34.89496  ? 158  ALA A C     1 
ATOM   1184 O O     . ALA A 1 178 ? 1.49200   40.92500  8.20100   1.000 34.82805  ? 158  ALA A O     1 
ATOM   1185 C CB    . ALA A 1 178 ? 1.39500   40.40600  5.14900   1.000 31.82097  ? 158  ALA A CB    1 
ATOM   1186 N N     . VAL A 1 179 ? 0.74500   38.79100  8.04800   1.000 30.53857  ? 159  VAL A N     1 
ATOM   1187 C CA    . VAL A 1 179 ? 0.03300   38.85800  9.31600   1.000 31.65465  ? 159  VAL A CA    1 
ATOM   1188 C C     . VAL A 1 179 ? 0.95900   39.25700  10.46300  1.000 34.38066  ? 159  VAL A C     1 
ATOM   1189 O O     . VAL A 1 179 ? 0.51200   39.91200  11.40700  1.000 30.44163  ? 159  VAL A O     1 
ATOM   1190 C CB    . VAL A 1 179 ? -0.69600  37.52600  9.60500   1.000 29.36810  ? 159  VAL A CB    1 
ATOM   1191 C CG1   . VAL A 1 179 ? 0.26600   36.36600  9.76300   1.000 29.93265  ? 159  VAL A CG1   1 
ATOM   1192 C CG2   . VAL A 1 179 ? -1.60600  37.66600  10.84200  1.000 27.28084  ? 159  VAL A CG2   1 
ATOM   1193 N N     . PHE A 1 180 ? 2.26600   38.92000  10.39600  1.000 36.61195  ? 160  PHE A N     1 
ATOM   1194 C CA    . PHE A 1 180 ? 3.10700   39.13200  11.58300  1.000 33.67752  ? 160  PHE A CA    1 
ATOM   1195 C C     . PHE A 1 180 ? 3.56700   40.58300  11.74600  1.000 32.34951  ? 160  PHE A C     1 
ATOM   1196 O O     . PHE A 1 180 ? 3.83300   41.01800  12.87600  1.000 36.48798  ? 160  PHE A O     1 
ATOM   1197 C CB    . PHE A 1 180 ? 4.34100   38.21300  11.57000  1.000 35.33240  ? 160  PHE A CB    1 
ATOM   1198 C CG    . PHE A 1 180 ? 3.99900   36.74200  11.45300  1.000 32.85581  ? 160  PHE A CG    1 
ATOM   1199 C CD1   . PHE A 1 180 ? 3.21600   36.13300  12.40800  1.000 33.66619  ? 160  PHE A CD1   1 
ATOM   1200 C CD2   . PHE A 1 180 ? 4.44200   35.99000  10.37100  1.000 34.35077  ? 160  PHE A CD2   1 
ATOM   1201 C CE1   . PHE A 1 180 ? 2.87000   34.79100  12.30400  1.000 29.43530  ? 160  PHE A CE1   1 
ATOM   1202 C CE2   . PHE A 1 180 ? 4.10800   34.63500  10.26300  1.000 35.17011  ? 160  PHE A CE2   1 
ATOM   1203 C CZ    . PHE A 1 180 ? 3.30400   34.04300  11.24300  1.000 31.21152  ? 160  PHE A CZ    1 
ATOM   1204 N N     . ALA A 1 181 ? 3.68300   41.33200  10.66200  1.000 30.73957  ? 161  ALA A N     1 
ATOM   1205 C CA    . ALA A 1 181 ? 4.14900   42.70700  10.75400  1.000 35.78663  ? 161  ALA A CA    1 
ATOM   1206 C C     . ALA A 1 181 ? 3.04500   43.74500  10.62500  1.000 33.72678  ? 161  ALA A C     1 
ATOM   1207 O O     . ALA A 1 181 ? 3.20900   44.85800  11.11600  1.000 34.00113  ? 161  ALA A O     1 
ATOM   1208 C CB    . ALA A 1 181 ? 5.19900   42.97900  9.67800   1.000 38.78655  ? 161  ALA A CB    1 
ATOM   1209 N N     . LEU A 1 182 ? 1.94700   43.41900  9.95300   1.000 28.97459  ? 162  LEU A N     1 
ATOM   1210 C CA    . LEU A 1 182 ? 0.82200   44.33600  9.81700   1.000 30.75884  ? 162  LEU A CA    1 
ATOM   1211 C C     . LEU A 1 182 ? 0.26200   44.76000  11.17700  1.000 30.31321  ? 162  LEU A C     1 
ATOM   1212 O O     . LEU A 1 182 ? 0.20200   43.95000  12.11400  1.000 29.94031  ? 162  LEU A O     1 
ATOM   1213 C CB    . LEU A 1 182 ? -0.27500  43.63900  9.03200   1.000 30.94166  ? 162  LEU A CB    1 
ATOM   1214 C CG    . LEU A 1 182 ? -1.21100  44.52700  8.27400   1.000 40.17189  ? 162  LEU A CG    1 
ATOM   1215 C CD1   . LEU A 1 182 ? -0.38300  45.36600  7.26900   1.000 37.99740  ? 162  LEU A CD1   1 
ATOM   1216 C CD2   . LEU A 1 182 ? -2.19300  43.56700  7.57700   1.000 39.42214  ? 162  LEU A CD2   1 
ATOM   1217 N N     . PRO A 1 183 ? -0.22100  45.99800  11.29800  1.000 28.17109  ? 163  PRO A N     1 
ATOM   1218 C CA    . PRO A 1 183 ? -0.87600  46.40300  12.54600  1.000 29.31845  ? 163  PRO A CA    1 
ATOM   1219 C C     . PRO A 1 183 ? -2.30000  45.84000  12.59000  1.000 27.35835  ? 163  PRO A C     1 
ATOM   1220 O O     . PRO A 1 183 ? -3.28700  46.53300  12.35500  1.000 26.16949  ? 163  PRO A O     1 
ATOM   1221 C CB    . PRO A 1 183 ? -0.86300  47.93100  12.45400  1.000 30.62771  ? 163  PRO A CB    1 
ATOM   1222 C CG    . PRO A 1 183 ? -0.94200  48.19900  10.94000  1.000 31.88975  ? 163  PRO A CG    1 
ATOM   1223 C CD    . PRO A 1 183 ? -0.20300  47.08600  10.29400  1.000 30.37229  ? 163  PRO A CD    1 
ATOM   1224 N N     . VAL A 1 184 ? -2.41700  44.54800  12.85500  1.000 23.50662  ? 164  VAL A N     1 
ATOM   1225 C CA    . VAL A 1 184 ? -3.71300  43.86100  12.87600  1.000 26.98327  ? 164  VAL A CA    1 
ATOM   1226 C C     . VAL A 1 184 ? -3.98800  43.39400  14.31200  1.000 30.65485  ? 164  VAL A C     1 
ATOM   1227 O O     . VAL A 1 184 ? -3.09000  42.88500  14.98000  1.000 26.72701  ? 164  VAL A O     1 
ATOM   1228 C CB    . VAL A 1 184 ? -3.74700  42.68900  11.87300  1.000 29.68540  ? 164  VAL A CB    1 
ATOM   1229 C CG1   . VAL A 1 184 ? -2.54700  41.77300  12.04300  1.000 28.84978  ? 164  VAL A CG1   1 
ATOM   1230 C CG2   . VAL A 1 184 ? -5.03600  41.90600  11.98700  1.000 24.05687  ? 164  VAL A CG2   1 
ATOM   1231 N N     . TYR A 1 185 ? -5.22500  43.60300  14.80200  1.000 26.06692  ? 165  TYR A N     1 
ATOM   1232 C CA    . TYR A 1 185 ? -5.52100  43.34500  16.20300  1.000 23.23356  ? 165  TYR A CA    1 
ATOM   1233 C C     . TYR A 1 185 ? -6.86400  42.63300  16.31700  1.000 23.04281  ? 165  TYR A C     1 
ATOM   1234 O O     . TYR A 1 185 ? -7.88300  43.17300  15.87000  1.000 22.33782  ? 165  TYR A O     1 
ATOM   1235 C CB    . TYR A 1 185 ? -5.55900  44.64800  17.02500  1.000 23.60599  ? 165  TYR A CB    1 
ATOM   1236 C CG    . TYR A 1 185 ? -4.24900  45.38000  17.08000  1.000 28.99978  ? 165  TYR A CG    1 
ATOM   1237 C CD1   . TYR A 1 185 ? -3.80900  46.13900  15.98900  1.000 27.33031  ? 165  TYR A CD1   1 
ATOM   1238 C CD2   . TYR A 1 185 ? -3.42700  45.29100  18.20200  1.000 31.25767  ? 165  TYR A CD2   1 
ATOM   1239 C CE1   . TYR A 1 185 ? -2.55400  46.80700  16.03200  1.000 32.01685  ? 165  TYR A CE1   1 
ATOM   1240 C CE2   . TYR A 1 185 ? -2.18600  45.94600  18.25800  1.000 35.30752  ? 165  TYR A CE2   1 
ATOM   1241 C CZ    . TYR A 1 185 ? -1.75600  46.69000  17.17900  1.000 38.44701  ? 165  TYR A CZ    1 
ATOM   1242 O OH    . TYR A 1 185 ? -0.54800  47.33200  17.23500  1.000 41.73931  ? 165  TYR A OH    1 
ATOM   1243 N N     . PRO A 1 186 ? -6.92000  41.47400  16.95500  1.000 24.96557  ? 166  PRO A N     1 
ATOM   1244 C CA    . PRO A 1 186 ? -8.23100  40.87700  17.26300  1.000 27.00048  ? 166  PRO A CA    1 
ATOM   1245 C C     . PRO A 1 186 ? -8.85900  41.58600  18.44900  1.000 25.64861  ? 166  PRO A C     1 
ATOM   1246 O O     . PRO A 1 186 ? -8.19400  41.85400  19.45300  1.000 25.40785  ? 166  PRO A O     1 
ATOM   1247 C CB    . PRO A 1 186 ? -7.90400  39.41100  17.60200  1.000 28.08989  ? 166  PRO A CB    1 
ATOM   1248 C CG    . PRO A 1 186 ? -6.37600  39.30600  17.57300  1.000 32.61039  ? 166  PRO A CG    1 
ATOM   1249 C CD    . PRO A 1 186 ? -5.80300  40.69600  17.51600  1.000 26.01887  ? 166  PRO A CD    1 
ATOM   1250 N N     . VAL A 1 187 ? -10.15100 41.89500  18.32300  1.000 24.19843  ? 167  VAL A N     1 
ATOM   1251 C CA    . VAL A 1 187 ? -10.86600 42.65100  19.34500  1.000 27.44596  ? 167  VAL A CA    1 
ATOM   1252 C C     . VAL A 1 187 ? -12.26700 42.08500  19.46200  1.000 33.80565  ? 167  VAL A C     1 
ATOM   1253 O O     . VAL A 1 187 ? -12.79700 41.49000  18.51000  1.000 27.87491  ? 167  VAL A O     1 
ATOM   1254 C CB    . VAL A 1 187 ? -10.97500 44.16600  19.02700  1.000 27.58294  ? 167  VAL A CB    1 
ATOM   1255 C CG1   . VAL A 1 187 ? -9.61800  44.85000  19.15900  1.000 27.90442  ? 167  VAL A CG1   1 
ATOM   1256 C CG2   . VAL A 1 187 ? -11.66400 44.37400  17.61700  1.000 23.45006  ? 167  VAL A CG2   1 
ATOM   1257 N N     . ALA A 1 188 ? -12.84500 42.24400  20.66300  1.000 28.11153  ? 168  ALA A N     1 
ATOM   1258 C CA    . ALA A 1 188 ? -14.27000 42.05300  20.84800  1.000 31.35514  ? 168  ALA A CA    1 
ATOM   1259 C C     . ALA A 1 188 ? -15.03500 43.11000  20.06300  1.000 29.58227  ? 168  ALA A C     1 
ATOM   1260 O O     . ALA A 1 188 ? -14.60800 44.26500  19.97200  1.000 28.84040  ? 168  ALA A O     1 
ATOM   1261 C CB    . ALA A 1 188 ? -14.63600 42.17100  22.33900  1.000 32.78880  ? 168  ALA A CB    1 
ATOM   1262 N N     . GLU A 1 189 ? -16.18400 42.70500  19.51700  1.000 31.60214  ? 169  GLU A N     1 
ATOM   1263 C CA    . GLU A 1 189 ? -17.01700 43.61900  18.74000  1.000 37.30679  ? 169  GLU A CA    1 
ATOM   1264 C C     . GLU A 1 189 ? -17.26100 44.91500  19.49600  1.000 35.54839  ? 169  GLU A C     1 
ATOM   1265 O O     . GLU A 1 189 ? -17.13900 46.01600  18.94000  1.000 32.35756  ? 169  GLU A O     1 
ATOM   1266 C CB    . GLU A 1 189 ? -18.32300 42.90200  18.37700  1.000 38.58856  ? 169  GLU A CB    1 
ATOM   1267 C CG    . GLU A 1 189 ? -19.50200 43.76900  17.94900  1.000 45.66235  ? 169  GLU A CG    1 
ATOM   1268 C CD    . GLU A 1 189 ? -20.60600 42.92900  17.27000  1.000 52.23577  ? 169  GLU A CD    1 
ATOM   1269 O OE1   . GLU A 1 189 ? -20.34000 41.75200  16.93500  1.000 57.75554  ? 169  GLU A OE1   1 
ATOM   1270 O OE2   . GLU A 1 189 ? -21.73700 43.43300  17.06600  1.000 55.03941  ? 169  GLU A OE2   1 
ATOM   1271 N N     . GLU A 1 190 ? -17.53300 44.81100  20.79600  1.000 39.47537  ? 170  GLU A N     1 
ATOM   1272 C CA    . GLU A 1 190 ? -17.83000 46.01100  21.56200  1.000 33.63636  ? 170  GLU A CA    1 
ATOM   1273 C C     . GLU A 1 190 ? -16.58700 46.86300  21.75100  1.000 32.46511  ? 170  GLU A C     1 
ATOM   1274 O O     . GLU A 1 190 ? -16.68700 48.08400  21.86800  1.000 36.66075  ? 170  GLU A O     1 
ATOM   1275 C CB    . GLU A 1 190 ? -18.43000 45.60700  22.91900  1.000 42.13312  ? 170  GLU A CB    1 
ATOM   1276 C CG    . GLU A 1 190 ? -19.71600 44.75900  22.81800  1.000 43.90356  ? 170  GLU A CG    1 
ATOM   1277 C CD    . GLU A 1 190 ? -19.49900 43.26800  22.42400  1.000 51.50915  ? 170  GLU A CD    1 
ATOM   1278 O OE1   . GLU A 1 190 ? -18.38100 42.71300  22.63100  1.000 45.58935  ? 170  GLU A OE1   1 
ATOM   1279 O OE2   . GLU A 1 190 ? -20.47500 42.65400  21.90300  1.000 51.91681  ? 170  GLU A OE2   1 
ATOM   1280 N N     . GLU A 1 191 ? -15.40800 46.24700  21.77000  1.000 33.72235  ? 171  GLU A N     1 
ATOM   1281 C CA    . GLU A 1 191 ? -14.17700 47.03700  21.87400  1.000 34.86251  ? 171  GLU A CA    1 
ATOM   1282 C C     . GLU A 1 191 ? -13.85800 47.75000  20.55900  1.000 30.03860  ? 171  GLU A C     1 
ATOM   1283 O O     . GLU A 1 191 ? -13.31900 48.86700  20.55400  1.000 30.91810  ? 171  GLU A O     1 
ATOM   1284 C CB    . GLU A 1 191 ? -13.01800 46.13300  22.29300  1.000 30.95235  ? 171  GLU A CB    1 
ATOM   1285 C CG    . GLU A 1 191 ? -11.58300 46.71900  22.07700  1.000 29.75788  ? 171  GLU A CG    1 
ATOM   1286 C CD    . GLU A 1 191 ? -11.37100 48.06600  22.77200  1.000 39.09935  ? 171  GLU A CD    1 
ATOM   1287 O OE1   . GLU A 1 191 ? -12.12600 48.35200  23.72700  1.000 38.18242  ? 171  GLU A OE1   1 
ATOM   1288 O OE2   . GLU A 1 191 ? -10.45500 48.84300  22.35500  1.000 36.24241  ? 171  GLU A OE2   1 
ATOM   1289 N N     . ALA A 1 192 ? -14.15500 47.10500  19.43400  1.000 31.82151  ? 172  ALA A N     1 
ATOM   1290 C CA    . ALA A 1 192 ? -14.00500 47.79200  18.15600  1.000 30.17425  ? 172  ALA A CA    1 
ATOM   1291 C C     . ALA A 1 192 ? -14.83700 49.06500  18.15400  1.000 31.44390  ? 172  ALA A C     1 
ATOM   1292 O O     . ALA A 1 192 ? -14.34800 50.14000  17.78800  1.000 30.63188  ? 172  ALA A O     1 
ATOM   1293 C CB    . ALA A 1 192 ? -14.41700 46.86900  17.01200  1.000 29.61988  ? 172  ALA A CB    1 
ATOM   1294 N N     . ALA A 1 193 ? -16.09300 48.96100  18.60900  1.000 33.55121  ? 173  ALA A N     1 
ATOM   1295 C CA    . ALA A 1 193 ? -16.97800 50.12400  18.64100  1.000 35.81069  ? 173  ALA A CA    1 
ATOM   1296 C C     . ALA A 1 193 ? -16.40300 51.23200  19.52000  1.000 34.47945  ? 173  ALA A C     1 
ATOM   1297 O O     . ALA A 1 193 ? -16.39900 52.40400  19.12900  1.000 37.12695  ? 173  ALA A O     1 
ATOM   1298 C CB    . ALA A 1 193 ? -18.37100 49.70600  19.12200  1.000 36.18458  ? 173  ALA A CB    1 
ATOM   1299 N N     . ARG A 1 194 ? -15.85700 50.87200  20.68600  1.000 36.31033  ? 174  ARG A N     1 
ATOM   1300 C CA    . ARG A 1 194 ? -15.27500 51.86200  21.59000  1.000 35.82338  ? 174  ARG A CA    1 
ATOM   1301 C C     . ARG A 1 194 ? -14.01300 52.48700  21.01700  1.000 38.90549  ? 174  ARG A C     1 
ATOM   1302 O O     . ARG A 1 194 ? -13.78900 53.69800  21.16300  1.000 32.84949  ? 174  ARG A O     1 
ATOM   1303 C CB    . ARG A 1 194 ? -14.91300 51.21900  22.93000  1.000 39.29476  ? 174  ARG A CB    1 
ATOM   1304 C CG    . ARG A 1 194 ? -16.07300 50.78700  23.80100  1.000 39.60361  ? 174  ARG A CG    1 
ATOM   1305 C CD    . ARG A 1 194 ? -15.52900 50.46600  25.21100  1.000 44.38242  ? 174  ARG A CD    1 
ATOM   1306 N NE    . ARG A 1 194 ? -14.72300 49.24100  25.27600  1.000 39.25585  ? 174  ARG A NE    1 
ATOM   1307 C CZ    . ARG A 1 194 ? -15.25100 48.03200  25.46700  1.000 39.77981  ? 174  ARG A CZ    1 
ATOM   1308 N NH1   . ARG A 1 194 ? -16.57000 47.91000  25.56500  1.000 39.49068  ? 174  ARG A NH1   1 
ATOM   1309 N NH2   . ARG A 1 194 ? -14.47400 46.94400  25.52800  1.000 39.58388  ? 174  ARG A NH2   1 
ATOM   1310 N N     . PHE A 1 195 ? -13.12100 51.66200  20.46300  1.000 36.14634  ? 175  PHE A N     1 
ATOM   1311 C CA    . PHE A 1 195 ? -11.90100 52.21500  19.88900  1.000 34.14060  ? 175  PHE A CA    1 
ATOM   1312 C C     . PHE A 1 195 ? -12.23200 53.19900  18.77200  1.000 36.29691  ? 175  PHE A C     1 
ATOM   1313 O O     . PHE A 1 195 ? -11.62500 54.27400  18.67700  1.000 34.08426  ? 175  PHE A O     1 
ATOM   1314 C CB    . PHE A 1 195 ? -11.01200 51.08700  19.38300  1.000 34.17971  ? 175  PHE A CB    1 
ATOM   1315 C CG    . PHE A 1 195 ? -9.73000  51.55700  18.81500  1.000 36.13637  ? 175  PHE A CG    1 
ATOM   1316 C CD1   . PHE A 1 195 ? -8.65500  51.82500  19.65000  1.000 38.75500  ? 175  PHE A CD1   1 
ATOM   1317 C CD2   . PHE A 1 195 ? -9.59900  51.76600  17.46000  1.000 34.72399  ? 175  PHE A CD2   1 
ATOM   1318 C CE1   . PHE A 1 195 ? -7.45600  52.27300  19.13600  1.000 40.36283  ? 175  PHE A CE1   1 
ATOM   1319 C CE2   . PHE A 1 195 ? -8.39800  52.22600  16.94800  1.000 34.02136  ? 175  PHE A CE2   1 
ATOM   1320 C CZ    . PHE A 1 195 ? -7.32800  52.46700  17.79000  1.000 36.97606  ? 175  PHE A CZ    1 
ATOM   1321 N N     . LEU A 1 196 ? -13.21300 52.85600  17.93100  1.000 33.23117  ? 176  LEU A N     1 
ATOM   1322 C CA    . LEU A 1 196 ? -13.60100 53.75500  16.84900  1.000 37.13101  ? 176  LEU A CA    1 
ATOM   1323 C C     . LEU A 1 196 ? -14.17900 55.06300  17.39900  1.000 38.73213  ? 176  LEU A C     1 
ATOM   1324 O O     . LEU A 1 196 ? -13.81800 56.15600  16.94200  1.000 35.89670  ? 176  LEU A O     1 
ATOM   1325 C CB    . LEU A 1 196 ? -14.60700 53.05300  15.91900  1.000 34.00229  ? 176  LEU A CB    1 
ATOM   1326 C CG    . LEU A 1 196 ? -14.11200 51.80700  15.17200  1.000 33.64558  ? 176  LEU A CG    1 
ATOM   1327 C CD1   . LEU A 1 196 ? -15.31200 51.08100  14.54200  1.000 31.25306  ? 176  LEU A CD1   1 
ATOM   1328 C CD2   . LEU A 1 196 ? -13.01700 52.18000  14.14800  1.000 38.61328  ? 176  LEU A CD2   1 
ATOM   1329 N N     . GLU A 1 197 ? -15.07900 54.97600  18.38500  1.000 39.32796  ? 177  GLU A N     1 
ATOM   1330 C CA    . GLU A 1 197 ? -15.59300 56.19800  19.00400  1.000 42.64126  ? 177  GLU A CA    1 
ATOM   1331 C C     . GLU A 1 197 ? -14.45900 57.00900  19.63100  1.000 38.57986  ? 177  GLU A C     1 
ATOM   1332 O O     . GLU A 1 197 ? -14.36000 58.22500  19.42000  1.000 45.05778  ? 177  GLU A O     1 
ATOM   1333 C CB    . GLU A 1 197 ? -16.66500 55.84700  20.02900  1.000 45.10190  ? 177  GLU A CB    1 
ATOM   1334 C CG    . GLU A 1 197 ? -17.39700 57.06200  20.64900  1.000 52.68566  ? 177  GLU A CG    1 
ATOM   1335 C CD    . GLU A 1 197 ? -17.99300 58.04400  19.62200  1.000 63.26019  ? 177  GLU A CD    1 
ATOM   1336 O OE1   . GLU A 1 197 ? -18.42000 57.62200  18.51100  1.000 64.79393  ? 177  GLU A OE1   1 
ATOM   1337 O OE2   . GLU A 1 197 ? -18.03700 59.25900  19.94000  1.000 67.51337  ? 177  GLU A OE2   1 
ATOM   1338 N N     . GLU A 1 198 ? -13.55900 56.33800  20.35200  1.000 39.16077  ? 178  GLU A N     1 
ATOM   1339 C CA    . GLU A 1 198 ? -12.42600 57.01300  20.98300  1.000 41.12592  ? 178  GLU A CA    1 
ATOM   1340 C C     . GLU A 1 198 ? -11.59100 57.80100  19.98400  1.000 43.93040  ? 178  GLU A C     1 
ATOM   1341 O O     . GLU A 1 198 ? -11.09100 58.88800  20.29800  1.000 43.59284  ? 178  GLU A O     1 
ATOM   1342 C CB    . GLU A 1 198 ? -11.53100 55.98400  21.67900  1.000 45.22713  ? 178  GLU A CB    1 
ATOM   1343 C CG    . GLU A 1 198 ? -12.06800 55.46800  23.02600  1.000 48.00653  ? 178  GLU A CG    1 
ATOM   1344 C CD    . GLU A 1 198 ? -11.44600 54.12500  23.43900  1.000 50.65080  ? 178  GLU A CD    1 
ATOM   1345 O OE1   . GLU A 1 198 ? -10.33500 53.77200  22.94000  1.000 43.12578  ? 178  GLU A OE1   1 
ATOM   1346 O OE2   . GLU A 1 198 ? -12.08600 53.42200  24.26200  1.000 53.68330  ? 178  GLU A OE2   1 
ATOM   1347 N N     . GLN A 1 199 ? -11.35600 57.23600  18.80200  1.000 42.19980  ? 179  GLN A N     1 
ATOM   1348 C CA    . GLN A 1 199 ? -10.47600 57.86000  17.82400  1.000 40.83564  ? 179  GLN A CA    1 
ATOM   1349 C C     . GLN A 1 199 ? -11.20200 58.86000  16.96100  1.000 38.53345  ? 179  GLN A C     1 
ATOM   1350 O O     . GLN A 1 199 ? -10.56700 59.49700  16.11700  1.000 41.20761  ? 179  GLN A O     1 
ATOM   1351 C CB    . GLN A 1 199 ? -9.83700  56.80500  16.91500  1.000 41.90552  ? 179  GLN A CB    1 
ATOM   1352 C CG    . GLN A 1 199 ? -8.99400  55.77300  17.64100  1.000 41.47729  ? 179  GLN A CG    1 
ATOM   1353 C CD    . GLN A 1 199 ? -7.69200  56.34400  18.15600  1.000 44.19353  ? 179  GLN A CD    1 
ATOM   1354 O OE1   . GLN A 1 199 ? -6.97400  57.03800  17.42800  1.000 49.52511  ? 179  GLN A OE1   1 
ATOM   1355 N NE2   . GLN A 1 199 ? -7.37200  56.05200  19.41200  1.000 43.20379  ? 179  GLN A NE2   1 
ATOM   1356 N N     . ASN A 1 200 ? -12.51000 58.99200  17.13500  1.000 37.68817  ? 180  ASN A N     1 
ATOM   1357 C CA    . ASN A 1 200 ? -13.32600 59.88200  16.31400  1.000 47.13121  ? 180  ASN A CA    1 
ATOM   1358 C C     . ASN A 1 200 ? -13.06100 59.62000  14.82700  1.000 44.91707  ? 180  ASN A C     1 
ATOM   1359 O O     . ASN A 1 200 ? -12.77500 60.53000  14.04900  1.000 45.44523  ? 180  ASN A O     1 
ATOM   1360 C CB    . ASN A 1 200 ? -13.08500 61.35800  16.67800  1.000 45.75798  ? 180  ASN A CB    1 
ATOM   1361 C CG    . ASN A 1 200 ? -14.25200 62.26200  16.27500  1.000 59.56375  ? 180  ASN A CG    1 
ATOM   1362 O OD1   . ASN A 1 200 ? -15.40000 61.80600  16.16100  1.000 61.06262  ? 180  ASN A OD1   1 
ATOM   1363 N ND2   . ASN A 1 200 ? -13.96500 63.55000  16.05100  1.000 59.94687  ? 180  ASN A ND2   1 
ATOM   1364 N N     . LEU A 1 201 ? -13.14600 58.31800  14.43000  1.000 40.54164  ? 181  LEU A N     1 
ATOM   1365 C CA    . LEU A 1 201 ? -12.91300 57.92000  13.04000  1.000 38.10102  ? 181  LEU A CA    1 
ATOM   1366 C C     . LEU A 1 201 ? -14.22400 57.78300  12.31900  1.000 38.56794  ? 181  LEU A C     1 
ATOM   1367 O O     . LEU A 1 201 ? -15.08500 57.01600  12.77300  1.000 35.63899  ? 181  LEU A O     1 
ATOM   1368 C CB    . LEU A 1 201 ? -12.17400 56.58700  12.98300  1.000 37.45609  ? 181  LEU A CB    1 
ATOM   1369 C CG    . LEU A 1 201 ? -10.66100 56.60600  13.03700  1.000 42.03989  ? 181  LEU A CG    1 
ATOM   1370 C CD1   . LEU A 1 201 ? -10.10400 55.22800  13.38500  1.000 38.46274  ? 181  LEU A CD1   1 
ATOM   1371 C CD2   . LEU A 1 201 ? -10.16800 57.06100  11.69000  1.000 38.13205  ? 181  LEU A CD2   1 
ATOM   1372 N N     . PRO A 1 202 ? -14.41200 58.45800  11.18900  1.000 38.04130  ? 182  PRO A N     1 
ATOM   1373 C CA    . PRO A 1 202 ? -15.63700 58.24300  10.40500  1.000 35.01500  ? 182  PRO A CA    1 
ATOM   1374 C C     . PRO A 1 202 ? -15.74000 56.78900  9.94700   1.000 35.28064  ? 182  PRO A C     1 
ATOM   1375 O O     . PRO A 1 202 ? -14.77000 56.19600  9.45400   1.000 34.14466  ? 182  PRO A O     1 
ATOM   1376 C CB    . PRO A 1 202 ? -15.47300 59.19900  9.21800   1.000 35.65816  ? 182  PRO A CB    1 
ATOM   1377 C CG    . PRO A 1 202 ? -14.39700 60.15600  9.62800   1.000 41.55693  ? 182  PRO A CG    1 
ATOM   1378 C CD    . PRO A 1 202 ? -13.48600 59.39500  10.54400  1.000 39.17393  ? 182  PRO A CD    1 
ATOM   1379 N N     . LEU A 1 203 ? -16.92300 56.20900  10.10400  1.000 33.82388  ? 183  LEU A N     1 
ATOM   1380 C CA    . LEU A 1 203 ? -17.12500 54.81000  9.76100   1.000 34.33522  ? 183  LEU A CA    1 
ATOM   1381 C C     . LEU A 1 203 ? -17.85900 54.72700  8.42800   1.000 30.52166  ? 183  LEU A C     1 
ATOM   1382 O O     . LEU A 1 203 ? -18.85100 55.42900  8.21800   1.000 31.08135  ? 183  LEU A O     1 
ATOM   1383 C CB    . LEU A 1 203 ? -17.92000 54.09900  10.84700  1.000 35.50404  ? 183  LEU A CB    1 
ATOM   1384 C CG    . LEU A 1 203 ? -17.37100 54.25900  12.26700  1.000 39.44701  ? 183  LEU A CG    1 
ATOM   1385 C CD1   . LEU A 1 203 ? -18.15900 53.36900  13.25200  1.000 41.50317  ? 183  LEU A CD1   1 
ATOM   1386 C CD2   . LEU A 1 203 ? -15.88600 53.92500  12.31800  1.000 35.11359  ? 183  LEU A CD2   1 
ATOM   1387 N N     . VAL A 1 204 ? -17.35000 53.90600  7.52400   1.000 29.17152  ? 184  VAL A N     1 
ATOM   1388 C CA    . VAL A 1 204 ? -17.94100 53.74200  6.20400   1.000 26.93931  ? 184  VAL A CA    1 
ATOM   1389 C C     . VAL A 1 204 ? -18.31600 52.27100  6.06000   1.000 23.15586  ? 184  VAL A C     1 
ATOM   1390 O O     . VAL A 1 204 ? -17.43300 51.39600  6.02500   1.000 22.53043  ? 184  VAL A O     1 
ATOM   1391 C CB    . VAL A 1 204 ? -16.98800 54.19200  5.09300   1.000 26.32339  ? 184  VAL A CB    1 
ATOM   1392 C CG1   . VAL A 1 204 ? -17.62500 53.85500  3.73500   1.000 23.19159  ? 184  VAL A CG1   1 
ATOM   1393 C CG2   . VAL A 1 204 ? -16.74100 55.67900  5.20500   1.000 29.37585  ? 184  VAL A CG2   1 
ATOM   1394 N N     . ALA A 1 205 ? -19.61800 51.98300  6.03500   1.000 25.34735  ? 185  ALA A N     1 
ATOM   1395 C CA    . ALA A 1 205 ? -20.09900 50.60500  5.99100   1.000 27.60486  ? 185  ALA A CA    1 
ATOM   1396 C C     . ALA A 1 205 ? -20.20400 50.13200  4.54400   1.000 27.56225  ? 185  ALA A C     1 
ATOM   1397 O O     . ALA A 1 205 ? -20.98800 50.68300  3.76300   1.000 27.92544  ? 185  ALA A O     1 
ATOM   1398 C CB    . ALA A 1 205 ? -21.47100 50.47900  6.67000   1.000 29.92422  ? 185  ALA A CB    1 
ATOM   1399 N N     . ALA A 1 206 ? -19.46600 49.08000  4.21600   1.000 23.04059  ? 186  ALA A N     1 
ATOM   1400 C CA    . ALA A 1 206 ? -19.55900 48.48900  2.86700   1.000 22.41512  ? 186  ALA A CA    1 
ATOM   1401 C C     . ALA A 1 206 ? -20.68500 47.45900  2.88300   1.000 24.57684  ? 186  ALA A C     1 
ATOM   1402 O O     . ALA A 1 206 ? -20.63000 46.52900  3.68000   1.000 27.18874  ? 186  ALA A O     1 
ATOM   1403 C CB    . ALA A 1 206 ? -18.25400 47.85900  2.48500   1.000 24.83072  ? 186  ALA A CB    1 
ATOM   1404 N N     . THR A 1 207 ? -21.68300 47.66300  2.03400   1.000 24.72098  ? 187  THR A N     1 
ATOM   1405 C CA    . THR A 1 207 ? -22.77500 46.69500  2.00000   1.000 25.40915  ? 187  THR A CA    1 
ATOM   1406 C C     . THR A 1 207 ? -23.41600 46.71200  0.61900   1.000 24.27312  ? 187  THR A C     1 
ATOM   1407 O O     . THR A 1 207 ? -23.44000 47.76700  -0.01800  1.000 24.87466  ? 187  THR A O     1 
ATOM   1408 C CB    . THR A 1 207 ? -23.78400 47.00700  3.11800   1.000 30.40158  ? 187  THR A CB    1 
ATOM   1409 O OG1   . THR A 1 207 ? -24.68000 45.90800  3.27000   1.000 33.73636  ? 187  THR A OG1   1 
ATOM   1410 C CG2   . THR A 1 207 ? -24.55700 48.35800  2.86200   1.000 31.65803  ? 187  THR A CG2   1 
ATOM   1411 N N     . PRO A 1 208 ? -23.82900 45.56200  0.07800   1.000 25.62996  ? 188  PRO A N     1 
ATOM   1412 C CA    . PRO A 1 208 ? -24.20500 45.52500  -1.35100  1.000 27.73463  ? 188  PRO A CA    1 
ATOM   1413 C C     . PRO A 1 208 ? -25.33600 46.44800  -1.70000  1.000 32.16181  ? 188  PRO A C     1 
ATOM   1414 O O     . PRO A 1 208 ? -25.45600 46.84900  -2.86700  1.000 30.91758  ? 188  PRO A O     1 
ATOM   1415 C CB    . PRO A 1 208 ? -24.60200 44.06600  -1.59200  1.000 29.40746  ? 188  PRO A CB    1 
ATOM   1416 C CG    . PRO A 1 208 ? -23.92800 43.31600  -0.50000  1.000 28.53672  ? 188  PRO A CG    1 
ATOM   1417 C CD    . PRO A 1 208 ? -23.93200 44.24000  0.70200   1.000 27.68831  ? 188  PRO A CD    1 
ATOM   1418 N N     . GLU A 1 209 ? -26.12700 46.85700  -0.71100  1.000 28.98809  ? 189  GLU A N     1 
ATOM   1419 C CA    . GLU A 1 209 ? -27.32100 47.70300  -0.96200  1.000 32.01093  ? 189  GLU A CA    1 
ATOM   1420 C C     . GLU A 1 209 ? -27.04600 49.15100  -0.53800  1.000 32.39133  ? 189  GLU A C     1 
ATOM   1421 O O     . GLU A 1 209 ? -27.97000 49.96200  -0.60100  1.000 36.21110  ? 189  GLU A O     1 
ATOM   1422 C CB    . GLU A 1 209 ? -28.51600 47.12300  -0.21000  1.000 32.34703  ? 189  GLU A CB    1 
ATOM   1423 C CG    . GLU A 1 209 ? -28.55700 47.50400  1.26700   1.000 40.76514  ? 189  GLU A CG    1 
ATOM   1424 C CD    . GLU A 1 209 ? -27.66500 46.73600  2.22600   1.000 40.52633  ? 189  GLU A CD    1 
ATOM   1425 O OE1   . GLU A 1 209 ? -26.92800 45.82600  1.79400   1.000 39.03571  ? 189  GLU A OE1   1 
ATOM   1426 O OE2   . GLU A 1 209 ? -27.71500 47.06500  3.42400   1.000 43.19952  ? 189  GLU A OE2   1 
ATOM   1427 N N     . GLY A 1 210 ? -25.80900 49.45500  -0.14400  1.000 31.51045  ? 190  GLY A N     1 
ATOM   1428 C CA    . GLY A 1 210 ? -25.41800 50.82000  0.24300   1.000 27.45640  ? 190  GLY A CA    1 
ATOM   1429 C C     . GLY A 1 210 ? -25.95300 51.88800  -0.68600  1.000 34.74467  ? 190  GLY A C     1 
ATOM   1430 O O     . GLY A 1 210 ? -25.88700 51.69500  -1.90600  1.000 34.44657  ? 190  GLY A O     1 
ATOM   1431 N N     . GLU A 1 211 ? -26.39700 53.01100  -0.12500  1.000 34.79059  ? 191  GLU A N     1 
ATOM   1432 C CA    . GLU A 1 211 ? -27.02300 54.10000  -0.91400  1.000 38.97981  ? 191  GLU A CA    1 
ATOM   1433 C C     . GLU A 1 211 ? -26.00600 54.82000  -1.80700  1.000 39.59668  ? 191  GLU A C     1 
ATOM   1434 O O     . GLU A 1 211 ? -26.42400 55.41100  -2.80200  1.000 35.61643  ? 191  GLU A O     1 
ATOM   1435 C CB    . GLU A 1 211 ? -27.63000 55.11500  0.05300   1.000 41.47611  ? 191  GLU A CB    1 
ATOM   1436 C CG    . GLU A 1 211 ? -26.60100 55.89700  0.86600   1.000 44.28953  ? 191  GLU A CG    1 
ATOM   1437 C CD    . GLU A 1 211 ? -26.32100 55.44000  2.29000   1.000 46.40888  ? 191  GLU A CD    1 
ATOM   1438 O OE1   . GLU A 1 211 ? -25.42700 56.02100  2.93700   1.000 40.81001  ? 191  GLU A OE1   1 
ATOM   1439 O OE2   . GLU A 1 211 ? -26.99900 54.50500  2.75300   1.000 46.77090  ? 191  GLU A OE2   1 
ATOM   1440 N N     . ARG A 1 212 ? -24.72700 54.75500  -1.46000  1.000 32.36662  ? 192  ARG A N     1 
ATOM   1441 C CA    . ARG A 1 212 ? -23.71800 55.52400  -2.22200  1.000 33.83420  ? 192  ARG A CA    1 
ATOM   1442 C C     . ARG A 1 212 ? -22.69300 54.63500  -2.93700  1.000 31.59343  ? 192  ARG A C     1 
ATOM   1443 O O     . ARG A 1 212 ? -22.12300 53.75800  -2.30500  1.000 25.34596  ? 192  ARG A O     1 
ATOM   1444 C CB    . ARG A 1 212 ? -22.93100 56.44500  -1.29100  1.000 36.13275  ? 192  ARG A CB    1 
ATOM   1445 C CG    . ARG A 1 212 ? -22.42500 57.65200  -2.06300  1.000 41.37520  ? 192  ARG A CG    1 
ATOM   1446 C CD    . ARG A 1 212 ? -21.54600 58.51600  -1.19800  1.000 47.48025  ? 192  ARG A CD    1 
ATOM   1447 N NE    . ARG A 1 212 ? -22.36100 59.35800  -0.32000  1.000 49.85460  ? 192  ARG A NE    1 
ATOM   1448 C CZ    . ARG A 1 212 ? -21.85500 60.19600  0.56400   1.000 46.27894  ? 192  ARG A CZ    1 
ATOM   1449 N NH1   . ARG A 1 212 ? -20.63600 60.66500  0.39200   1.000 47.13270  ? 192  ARG A NH1   1 
ATOM   1450 N NH2   . ARG A 1 212 ? -22.56700 60.55700  1.61300   1.000 43.20378  ? 192  ARG A NH2   1 
ATOM   1451 N N     . LEU A 1 213 ? -22.48700 54.89400  -4.21900  1.000 29.12082  ? 193  LEU A N     1 
ATOM   1452 C CA    . LEU A 1 213 ? -21.42600 54.17800  -4.94900  1.000 29.27198  ? 193  LEU A CA    1 
ATOM   1453 C C     . LEU A 1 213 ? -20.12500 54.47600  -4.20200  1.000 27.31991  ? 193  LEU A C     1 
ATOM   1454 O O     . LEU A 1 213 ? -19.92000 55.62800  -3.81100  1.000 29.19751  ? 193  LEU A O     1 
ATOM   1455 C CB    . LEU A 1 213 ? -21.34500 54.63700  -6.40000  1.000 31.74947  ? 193  LEU A CB    1 
ATOM   1456 C CG    . LEU A 1 213 ? -22.28400 53.96300  -7.39800  1.000 38.94649  ? 193  LEU A CG    1 
ATOM   1457 C CD1   . LEU A 1 213 ? -22.02600 54.59900  -8.75000  1.000 43.26242  ? 193  LEU A CD1   1 
ATOM   1458 C CD2   . LEU A 1 213 ? -22.03600 52.47100  -7.45200  1.000 33.89933  ? 193  LEU A CD2   1 
ATOM   1459 N N     . TYR A 1 214 ? -19.28000 53.47200  -4.03400  1.000 24.23797  ? 194  TYR A N     1 
ATOM   1460 C CA    . TYR A 1 214 ? -18.05200 53.65600  -3.21200  1.000 25.79938  ? 194  TYR A CA    1 
ATOM   1461 C C     . TYR A 1 214 ? -17.10100 54.72900  -3.76600  1.000 30.46818  ? 194  TYR A C     1 
ATOM   1462 O O     . TYR A 1 214 ? -16.36000 55.31800  -2.98600  1.000 26.41712  ? 194  TYR A O     1 
ATOM   1463 C CB    . TYR A 1 214 ? -17.35700 52.31200  -2.97500  1.000 24.39539  ? 194  TYR A CB    1 
ATOM   1464 C CG    . TYR A 1 214 ? -16.50900 51.69600  -4.07600  1.000 22.97831  ? 194  TYR A CG    1 
ATOM   1465 C CD1   . TYR A 1 214 ? -17.06800 51.28900  -5.27900  1.000 25.74786  ? 194  TYR A CD1   1 
ATOM   1466 C CD2   . TYR A 1 214 ? -15.15500 51.47100  -3.88200  1.000 23.11412  ? 194  TYR A CD2   1 
ATOM   1467 C CE1   . TYR A 1 214 ? -16.29600 50.70000  -6.26400  1.000 24.46195  ? 194  TYR A CE1   1 
ATOM   1468 C CE2   . TYR A 1 214 ? -14.37300 50.88800  -4.86100  1.000 24.47892  ? 194  TYR A CE2   1 
ATOM   1469 C CZ    . TYR A 1 214 ? -14.94400 50.50000  -6.05600  1.000 25.69175  ? 194  TYR A CZ    1 
ATOM   1470 O OH    . TYR A 1 214 ? -14.16100 49.92900  -7.01200  1.000 22.82198  ? 194  TYR A OH    1 
ATOM   1471 N N     . TRP A 1 215 ? -17.11000 54.93100  -5.07600  1.000 27.74629  ? 195  TRP A N     1 
ATOM   1472 C CA    . TRP A 1 215 ? -16.22200 55.93900  -5.70000  1.000 28.08793  ? 195  TRP A CA    1 
ATOM   1473 C C     . TRP A 1 215 ? -16.65100 57.35000  -5.29200  1.000 30.43937  ? 195  TRP A C     1 
ATOM   1474 O O     . TRP A 1 215 ? -15.85100 58.27200  -5.43700  1.000 32.97963  ? 195  TRP A O     1 
ATOM   1475 C CB    . TRP A 1 215 ? -16.26700 55.79100  -7.22500  1.000 27.62082  ? 195  TRP A CB    1 
ATOM   1476 C CG    . TRP A 1 215 ? -15.79900 54.47500  -7.77600  1.000 23.57999  ? 195  TRP A CG    1 
ATOM   1477 C CD1   . TRP A 1 215 ? -14.59600 53.87000  -7.57300  1.000 27.50126  ? 195  TRP A CD1   1 
ATOM   1478 C CD2   . TRP A 1 215 ? -16.53600 53.61700  -8.67100  1.000 25.87017  ? 195  TRP A CD2   1 
ATOM   1479 N NE1   . TRP A 1 215 ? -14.53500 52.69500  -8.26900  1.000 25.47514  ? 195  TRP A NE1   1 
ATOM   1480 C CE2   . TRP A 1 215 ? -15.70800 52.51200  -8.95000  1.000 24.95031  ? 195  TRP A CE2   1 
ATOM   1481 C CE3   . TRP A 1 215 ? -17.80600 53.67500  -9.25300  1.000 27.61687  ? 195  TRP A CE3   1 
ATOM   1482 C CZ2   . TRP A 1 215 ? -16.11400 51.47500  -9.78400  1.000 24.47345  ? 195  TRP A CZ2   1 
ATOM   1483 C CZ3   . TRP A 1 215 ? -18.20300 52.64900  -10.07800 1.000 25.63370  ? 195  TRP A CZ3   1 
ATOM   1484 C CH2   . TRP A 1 215 ? -17.36700 51.56700  -10.33800 1.000 27.78309  ? 195  TRP A CH2   1 
ATOM   1485 N N     . GLU A 1 216 ? -17.88500 57.50300  -4.81500  1.000 33.28730  ? 196  GLU A N     1 
ATOM   1486 C CA    . GLU A 1 216 ? -18.42700 58.80700  -4.45100  1.000 35.89679  ? 196  GLU A CA    1 
ATOM   1487 C C     . GLU A 1 216 ? -18.21200 59.16000  -2.98100  1.000 37.97599  ? 196  GLU A C     1 
ATOM   1488 O O     . GLU A 1 216 ? -18.70200 60.20400  -2.53500  1.000 43.24886  ? 196  GLU A O     1 
ATOM   1489 C CB    . GLU A 1 216 ? -19.92100 58.85200  -4.80400  1.000 29.33154  ? 196  GLU A CB    1 
ATOM   1490 C CG    . GLU A 1 216 ? -20.14500 58.50300  -6.26700  1.000 39.49670  ? 196  GLU A CG    1 
ATOM   1491 C CD    . GLU A 1 216 ? -21.55000 58.80500  -6.76700  1.000 47.51677  ? 196  GLU A CD    1 
ATOM   1492 O OE1   . GLU A 1 216 ? -22.49300 58.79100  -5.95600  1.000 48.66187  ? 196  GLU A OE1   1 
ATOM   1493 O OE2   . GLU A 1 216 ? -21.70500 59.04700  -7.98800  1.000 50.29453  ? 196  GLU A OE2   1 
ATOM   1494 N N     . GLY A 1 217 ? -17.49900 58.32800  -2.22000  1.000 34.84792  ? 197  GLY A N     1 
ATOM   1495 C CA    . GLY A 1 217 ? -17.07300 58.70900  -0.87800  1.000 32.90547  ? 197  GLY A CA    1 
ATOM   1496 C C     . GLY A 1 217 ? -15.73200 59.41200  -0.92200  1.000 33.33178  ? 197  GLY A C     1 
ATOM   1497 O O     . GLY A 1 217 ? -14.90300 59.14700  -1.79100  1.000 30.91947  ? 197  GLY A O     1 
ATOM   1498 N N     . ASP A 1 218 ? -15.50200 60.33800  0.01100   1.000 33.59530  ? 198  ASP A N     1 
ATOM   1499 C CA    . ASP A 1 218 ? -14.19600 60.99800  0.11300   1.000 31.73847  ? 198  ASP A CA    1 
ATOM   1500 C C     . ASP A 1 218 ? -13.39500 60.32400  1.22000   1.000 32.23126  ? 198  ASP A C     1 
ATOM   1501 O O     . ASP A 1 218 ? -13.78800 60.37800  2.39100   1.000 32.97852  ? 198  ASP A O     1 
ATOM   1502 C CB    . ASP A 1 218 ? -14.34900 62.49400  0.40300   1.000 31.50750  ? 198  ASP A CB    1 
ATOM   1503 C CG    . ASP A 1 218 ? -13.02800 63.25300  0.35600   1.000 34.06000  ? 198  ASP A CG    1 
ATOM   1504 O OD1   . ASP A 1 218 ? -11.92100 62.66700  0.47000   1.000 31.90673  ? 198  ASP A OD1   1 
ATOM   1505 O OD2   . ASP A 1 218 ? -13.10000 64.47600  0.21800   1.000 41.70363  ? 198  ASP A OD2   1 
ATOM   1506 N N     . TYR A 1 219 ? -12.28400 59.68000  0.86000   1.000 29.32430  ? 199  TYR A N     1 
ATOM   1507 C CA    . TYR A 1 219 ? -11.51500 58.89300  1.82300   1.000 28.30252  ? 199  TYR A CA    1 
ATOM   1508 C C     . TYR A 1 219 ? -10.15000 59.50400  2.06900   1.000 28.23316  ? 199  TYR A C     1 
ATOM   1509 O O     . TYR A 1 219 ? -9.21400  58.80500  2.47100   1.000 28.99300  ? 199  TYR A O     1 
ATOM   1510 C CB    . TYR A 1 219 ? -11.35800 57.42200  1.37900   1.000 24.91888  ? 199  TYR A CB    1 
ATOM   1511 C CG    . TYR A 1 219 ? -12.65000 56.80600  0.91800   1.000 26.42285  ? 199  TYR A CG    1 
ATOM   1512 C CD1   . TYR A 1 219 ? -13.75500 56.76400  1.76200   1.000 27.95393  ? 199  TYR A CD1   1 
ATOM   1513 C CD2   . TYR A 1 219 ? -12.79200 56.30700  -0.38900  1.000 25.85228  ? 199  TYR A CD2   1 
ATOM   1514 C CE1   . TYR A 1 219 ? -14.96900 56.24500  1.35000   1.000 26.12441  ? 199  TYR A CE1   1 
ATOM   1515 C CE2   . TYR A 1 219 ? -14.01800 55.76700  -0.81800  1.000 24.16723  ? 199  TYR A CE2   1 
ATOM   1516 C CZ    . TYR A 1 219 ? -15.10600 55.71900  0.07100   1.000 26.64854  ? 199  TYR A CZ    1 
ATOM   1517 O OH    . TYR A 1 219 ? -16.36000 55.20000  -0.34200  1.000 26.10632  ? 199  TYR A OH    1 
ATOM   1518 N N     . ARG A 1 220 ? -9.99100  60.78800  1.75900   1.000 28.10795  ? 200  ARG A N     1 
ATOM   1519 C CA    . ARG A 1 220 ? -8.67300  61.37400  1.94000   1.000 28.88821  ? 200  ARG A CA    1 
ATOM   1520 C C     . ARG A 1 220 ? -8.43500  61.80200  3.37800   1.000 27.67555  ? 200  ARG A C     1 
ATOM   1521 O O     . ARG A 1 220 ? -7.28700  61.86400  3.79600   1.000 33.07105  ? 200  ARG A O     1 
ATOM   1522 C CB    . ARG A 1 220 ? -8.50500  62.53800  0.96000   1.000 27.89492  ? 200  ARG A CB    1 
ATOM   1523 C CG    . ARG A 1 220 ? -8.60200  62.00700  -0.49100  1.000 26.72024  ? 200  ARG A CG    1 
ATOM   1524 C CD    . ARG A 1 220 ? -8.62800  63.12300  -1.52500  1.000 30.12752  ? 200  ARG A CD    1 
ATOM   1525 N NE    . ARG A 1 220 ? -9.88300  63.85000  -1.43000  1.000 31.30727  ? 200  ARG A NE    1 
ATOM   1526 C CZ    . ARG A 1 220 ? -10.26200 64.80200  -2.26300  1.000 39.10835  ? 200  ARG A CZ    1 
ATOM   1527 N NH1   . ARG A 1 220 ? -9.47800  65.15200  -3.28400  1.000 35.50769  ? 200  ARG A NH1   1 
ATOM   1528 N NH2   . ARG A 1 220 ? -11.43500 65.39300  -2.07700  1.000 38.31440  ? 200  ARG A NH2   1 
ATOM   1529 N N     . GLY A 1 221 ? -9.48400  62.00200  4.16600   1.000 30.21343  ? 201  GLY A N     1 
ATOM   1530 C CA    . GLY A 1 221 ? -9.34600  62.12000  5.60900   1.000 34.17433  ? 201  GLY A CA    1 
ATOM   1531 C C     . GLY A 1 221 ? -9.36500  60.76300  6.30200   1.000 34.56361  ? 201  GLY A C     1 
ATOM   1532 O O     . GLY A 1 221 ? -9.40400  59.70600  5.66600   1.000 32.31379  ? 201  GLY A O     1 
ATOM   1533 N N     . GLY A 1 222 ? -9.32700  60.79700  7.63600   1.000 34.81969  ? 202  GLY A N     1 
ATOM   1534 C CA    . GLY A 1 222 ? -9.37400  59.54400  8.38500   1.000 33.78469  ? 202  GLY A CA    1 
ATOM   1535 C C     . GLY A 1 222 ? -10.64800 58.76900  8.06500   1.000 34.02725  ? 202  GLY A C     1 
ATOM   1536 O O     . GLY A 1 222 ? -11.72800 59.34700  7.92700   1.000 34.97329  ? 202  GLY A O     1 
ATOM   1537 N N     . VAL A 1 223 ? -10.51700 57.45000  7.89200   1.000 30.79940  ? 203  VAL A N     1 
ATOM   1538 C CA    . VAL A 1 223 ? -11.66300 56.63500  7.50800   1.000 29.20850  ? 203  VAL A CA    1 
ATOM   1539 C C     . VAL A 1 223 ? -11.45800 55.21000  8.00600   1.000 23.23608  ? 203  VAL A C     1 
ATOM   1540 O O     . VAL A 1 223 ? -10.35800 54.66500  7.96200   1.000 26.85446  ? 203  VAL A O     1 
ATOM   1541 C CB    . VAL A 1 223 ? -11.88700 56.66500  5.96300   1.000 29.98991  ? 203  VAL A CB    1 
ATOM   1542 C CG1   . VAL A 1 223 ? -10.73100 56.04400  5.23400   1.000 29.24431  ? 203  VAL A CG1   1 
ATOM   1543 C CG2   . VAL A 1 223 ? -13.15100 55.94100  5.58700   1.000 31.00935  ? 203  VAL A CG2   1 
ATOM   1544 N N     . ALA A 1 224 ? -12.55200 54.58400  8.41500   1.000 24.72864  ? 204  ALA A N     1 
ATOM   1545 C CA    . ALA A 1 224 ? -12.55900 53.17100  8.79600   1.000 24.84394  ? 204  ALA A CA    1 
ATOM   1546 C C     . ALA A 1 224 ? -13.62600 52.50300  7.95600   1.000 23.95770  ? 204  ALA A C     1 
ATOM   1547 O O     . ALA A 1 224 ? -14.80900 52.84700  8.08300   1.000 25.80900  ? 204  ALA A O     1 
ATOM   1548 C CB    . ALA A 1 224 ? -12.86900 52.99600  10.28200  1.000 22.56766  ? 204  ALA A CB    1 
ATOM   1549 N N     . PHE A 1 225 ? -13.19200 51.54400  7.14500   1.000 25.18322  ? 205  PHE A N     1 
ATOM   1550 C CA    . PHE A 1 225 ? -14.13800 50.74300  6.32900   1.000 22.76139  ? 205  PHE A CA    1 
ATOM   1551 C C     . PHE A 1 225 ? -14.60300 49.54200  7.15100   1.000 23.58795  ? 205  PHE A C     1 
ATOM   1552 O O     . PHE A 1 225 ? -13.77600 48.87600  7.76900   1.000 23.84163  ? 205  PHE A O     1 
ATOM   1553 C CB    . PHE A 1 225 ? -13.52900 50.24200  5.01700   1.000 22.17145  ? 205  PHE A CB    1 
ATOM   1554 C CG    . PHE A 1 225 ? -13.17600 51.30500  3.98800   1.000 21.19372  ? 205  PHE A CG    1 
ATOM   1555 C CD1   . PHE A 1 225 ? -14.16900 51.99900  3.31300   1.000 23.07887  ? 205  PHE A CD1   1 
ATOM   1556 C CD2   . PHE A 1 225 ? -11.85300 51.58800  3.68300   1.000 22.94918  ? 205  PHE A CD2   1 
ATOM   1557 C CE1   . PHE A 1 225 ? -13.84600 52.95200  2.36500   1.000 24.44424  ? 205  PHE A CE1   1 
ATOM   1558 C CE2   . PHE A 1 225 ? -11.53700 52.54200  2.73200   1.000 23.74988  ? 205  PHE A CE2   1 
ATOM   1559 C CZ    . PHE A 1 225 ? -12.53200 53.22300  2.08000   1.000 22.87508  ? 205  PHE A CZ    1 
ATOM   1560 N N     . LEU A 1 226 ? -15.90300 49.27200  7.10700   1.000 24.68423  ? 206  LEU A N     1 
ATOM   1561 C CA    . LEU A 1 226 ? -16.49500 48.15400  7.83100   1.000 23.33854  ? 206  LEU A CA    1 
ATOM   1562 C C     . LEU A 1 226 ? -16.94900 47.07800  6.85400   1.000 24.60499  ? 206  LEU A C     1 
ATOM   1563 O O     . LEU A 1 226 ? -17.73200 47.36400  5.94300   1.000 25.22900  ? 206  LEU A O     1 
ATOM   1564 C CB    . LEU A 1 226 ? -17.70200 48.61200  8.65400   1.000 27.82380  ? 206  LEU A CB    1 
ATOM   1565 C CG    . LEU A 1 226 ? -17.67200 49.94000  9.41500   1.000 29.51007  ? 206  LEU A CG    1 
ATOM   1566 C CD1   . LEU A 1 226 ? -19.10800 50.24100  9.93500   1.000 32.24906  ? 206  LEU A CD1   1 
ATOM   1567 C CD2   . LEU A 1 226 ? -16.68700 49.88300  10.57100  1.000 28.72246  ? 206  LEU A CD2   1 
ATOM   1568 N N     . LEU A 1 227 ? -16.45200 45.85900  7.08900   1.000 17.84280  ? 207  LEU A N     1 
ATOM   1569 C CA    . LEU A 1 227 ? -16.76400 44.67700  6.25100   1.000 24.24661  ? 207  LEU A CA    1 
ATOM   1570 C C     . LEU A 1 227 ? -17.47300 43.62200  7.11700   1.000 23.81784  ? 207  LEU A C     1 
ATOM   1571 O O     . LEU A 1 227 ? -16.99900 43.37800  8.22900   1.000 23.13542  ? 207  LEU A O     1 
ATOM   1572 C CB    . LEU A 1 227 ? -15.49900 44.05800  5.66600   1.000 23.43926  ? 207  LEU A CB    1 
ATOM   1573 C CG    . LEU A 1 227 ? -14.81200 44.76200  4.49200   1.000 26.95590  ? 207  LEU A CG    1 
ATOM   1574 C CD1   . LEU A 1 227 ? -15.63700 44.80300  3.22900   1.000 24.32824  ? 207  LEU A CD1   1 
ATOM   1575 C CD2   . LEU A 1 227 ? -14.18100 46.10000  4.81300   1.000 24.34233  ? 207  LEU A CD2   1 
ATOM   1576 N N     . GLY A 1 228 ? -18.50800 42.98200  6.56700   1.000 25.38883  ? 208  GLY A N     1 
ATOM   1577 C CA    . GLY A 1 228 ? -19.29900 42.01100  7.29000   1.000 26.46133  ? 208  GLY A CA    1 
ATOM   1578 C C     . GLY A 1 228 ? -18.99300 40.55500  6.92500   1.000 27.54578  ? 208  GLY A C     1 
ATOM   1579 O O     . GLY A 1 228 ? -18.15600 40.23200  6.07400   1.000 23.20061  ? 208  GLY A O     1 
ATOM   1580 N N     . ALA A 1 229 ? -19.73600 39.66300  7.59200   1.000 26.57129  ? 209  ALA A N     1 
ATOM   1581 C CA    . ALA A 1 229 ? -19.53000 38.23000  7.47600   1.000 28.56820  ? 209  ALA A CA    1 
ATOM   1582 C C     . ALA A 1 229 ? -19.87700 37.73000  6.07500   1.000 31.49775  ? 209  ALA A C     1 
ATOM   1583 O O     . ALA A 1 229 ? -20.77000 38.25400  5.41000   1.000 26.61564  ? 209  ALA A O     1 
ATOM   1584 C CB    . ALA A 1 229 ? -20.39500 37.49200  8.50800   1.000 32.45895  ? 209  ALA A CB    1 
ATOM   1585 N N     . GLU A 1 230 ? -19.19400 36.67300  5.66200   1.000 22.03990  ? 210  GLU A N     1 
ATOM   1586 C CA    . GLU A 1 230 ? -19.42300 36.10800  4.31900   1.000 26.52530  ? 210  GLU A CA    1 
ATOM   1587 C C     . GLU A 1 230 ? -20.88600 35.69200  4.16300   1.000 34.09050  ? 210  GLU A C     1 
ATOM   1588 O O     . GLU A 1 230 ? -21.43600 35.89800  3.08000   1.000 34.15763  ? 210  GLU A O     1 
ATOM   1589 C CB    . GLU A 1 230 ? -18.53900 34.89000  4.08900   1.000 26.97516  ? 210  GLU A CB    1 
ATOM   1590 C CG    . GLU A 1 230 ? -17.04800 35.21100  4.06500   1.000 25.97955  ? 210  GLU A CG    1 
ATOM   1591 C CD    . GLU A 1 230 ? -16.32800 35.03200  5.38800   1.000 26.53980  ? 210  GLU A CD    1 
ATOM   1592 O OE1   . GLU A 1 230 ? -16.98300 35.13000  6.43800   1.000 28.41732  ? 210  GLU A OE1   1 
ATOM   1593 O OE2   . GLU A 1 230 ? -15.11000 34.79800  5.36100   1.000 27.38335  ? 210  GLU A OE2   1 
ATOM   1594 N N     . ASP A 1 231 ? -21.48100 35.11200  5.20500   1.000 34.60469  ? 211  ASP A N     1 
ATOM   1595 C CA    . ASP A 1 231 ? -22.84600 34.63300  4.95200   1.000 40.26888  ? 211  ASP A CA    1 
ATOM   1596 C C     . ASP A 1 231 ? -23.86900 35.72500  5.22100   1.000 43.33866  ? 211  ASP A C     1 
ATOM   1597 O O     . ASP A 1 231 ? -24.58900 36.14100  4.30800   1.000 46.56752  ? 211  ASP A O     1 
ATOM   1598 C CB    . ASP A 1 231 ? -23.17100 33.33600  5.72900   1.000 39.21253  ? 211  ASP A CB    1 
ATOM   1599 C CG    . ASP A 1 231 ? -22.88900 33.41200  7.23700   1.000 46.19627  ? 211  ASP A CG    1 
ATOM   1600 O OD1   . ASP A 1 231 ? -22.37600 34.44100  7.76500   1.000 43.61247  ? 211  ASP A OD1   1 
ATOM   1601 O OD2   . ASP A 1 231 ? -23.22000 32.40300  7.91100   1.000 49.85085  ? 211  ASP A OD2   1 
ATOM   1602 N N     . LYS A 1 232 ? -23.91600 36.23100  6.44400   1.000 38.06392  ? 212  LYS A N     1 
ATOM   1603 C CA    . LYS A 1 232 ? -24.98600 37.13600  6.84000   1.000 44.99484  ? 212  LYS A CA    1 
ATOM   1604 C C     . LYS A 1 232 ? -24.69100 38.60000  6.54900   1.000 40.93692  ? 212  LYS A C     1 
ATOM   1605 O O     . LYS A 1 232 ? -25.61600 39.41500  6.63300   1.000 40.40757  ? 212  LYS A O     1 
ATOM   1606 C CB    . LYS A 1 232 ? -25.26900 37.00000  8.34100   1.000 45.14545  ? 212  LYS A CB    1 
ATOM   1607 C CG    . LYS A 1 232 ? -25.53500 35.57100  8.81000   1.000 52.60342  ? 212  LYS A CG    1 
ATOM   1608 C CD    . LYS A 1 232 ? -26.77700 34.99700  8.14000   1.000 55.50015  ? 212  LYS A CD    1 
ATOM   1609 C CE    . LYS A 1 232 ? -27.21400 33.70800  8.84300   1.000 59.47722  ? 212  LYS A CE    1 
ATOM   1610 N NZ    . LYS A 1 232 ? -28.31200 33.04700  8.10000   1.000 64.16981  ? 212  LYS A NZ    1 
ATOM   1611 N N     . GLY A 1 233 ? -23.42900 38.96500  6.26400   1.000 34.19364  ? 213  GLY A N     1 
ATOM   1612 C CA    . GLY A 1 233 ? -23.10000 40.38300  6.08400   1.000 34.34445  ? 213  GLY A CA    1 
ATOM   1613 C C     . GLY A 1 233 ? -23.01100 41.18600  7.38000   1.000 34.22607  ? 213  GLY A C     1 
ATOM   1614 O O     . GLY A 1 233 ? -22.76000 40.65800  8.47000   1.000 36.53291  ? 213  GLY A O     1 
ATOM   1615 N N     . LEU A 1 234 ? -23.17700 42.51800  7.24400   1.000 29.60197  ? 214  LEU A N     1 
ATOM   1616 C CA    . LEU A 1 234 ? -23.00600 43.39300  8.39600   1.000 31.71263  ? 214  LEU A CA    1 
ATOM   1617 C C     . LEU A 1 234 ? -24.28400 43.41100  9.22700   1.000 37.57235  ? 214  LEU A C     1 
ATOM   1618 O O     . LEU A 1 234 ? -25.38500 43.47700  8.66700   1.000 34.89853  ? 214  LEU A O     1 
ATOM   1619 C CB    . LEU A 1 234 ? -22.68600 44.83700  7.95900   1.000 34.06138  ? 214  LEU A CB    1 
ATOM   1620 C CG    . LEU A 1 234 ? -21.26100 45.20100  7.52600   1.000 29.79056  ? 214  LEU A CG    1 
ATOM   1621 C CD1   . LEU A 1 234 ? -21.22800 46.65000  7.01600   1.000 26.98970  ? 214  LEU A CD1   1 
ATOM   1622 C CD2   . LEU A 1 234 ? -20.36200 45.05100  8.74900   1.000 27.87522  ? 214  LEU A CD2   1 
ATOM   1623 N N     . PRO A 1 235 ? -24.17300 43.39900  10.55200  1.000 36.60935  ? 215  PRO A N     1 
ATOM   1624 C CA    . PRO A 1 235 ? -25.37200 43.59200  11.37800  1.000 39.77264  ? 215  PRO A CA    1 
ATOM   1625 C C     . PRO A 1 235 ? -25.94500 44.99200  11.17100  1.000 42.27940  ? 215  PRO A C     1 
ATOM   1626 O O     . PRO A 1 235 ? -25.22200 45.95600  10.88500  1.000 35.73088  ? 215  PRO A O     1 
ATOM   1627 C CB    . PRO A 1 235 ? -24.85900 43.38900  12.81500  1.000 39.82665  ? 215  PRO A CB    1 
ATOM   1628 C CG    . PRO A 1 235 ? -23.48300 42.72900  12.69000  1.000 40.57525  ? 215  PRO A CG    1 
ATOM   1629 C CD    . PRO A 1 235 ? -22.94800 43.25000  11.35900  1.000 34.66576  ? 215  PRO A CD    1 
ATOM   1630 N N     . GLU A 1 236 ? -27.27200 45.10300  11.30900  1.000 44.19095  ? 216  GLU A N     1 
ATOM   1631 C CA    . GLU A 1 236 ? -27.92300 46.39900  11.12200  1.000 46.16431  ? 216  GLU A CA    1 
ATOM   1632 C C     . GLU A 1 236 ? -27.34600 47.46300  12.05200  1.000 41.41804  ? 216  GLU A C     1 
ATOM   1633 O O     . GLU A 1 236 ? -27.16500 48.61500  11.64500  1.000 43.31247  ? 216  GLU A O     1 
ATOM   1634 C CB    . GLU A 1 236 ? -29.43500 46.27100  11.32600  1.000 49.75208  ? 216  GLU A CB    1 
ATOM   1635 C CG    . GLU A 1 236 ? -30.09900 45.43900  10.25600  1.000 49.18408  ? 216  GLU A CG    1 
ATOM   1636 C CD    . GLU A 1 236 ? -29.87100 46.00800  8.85900   1.000 51.72151  ? 216  GLU A CD    1 
ATOM   1637 O OE1   . GLU A 1 236 ? -30.00900 47.25000  8.69900   1.000 52.07063  ? 216  GLU A OE1   1 
ATOM   1638 O OE2   . GLU A 1 236 ? -29.55800 45.21900  7.92900   1.000 54.72769  ? 216  GLU A OE2   1 
ATOM   1639 N N     . ALA A 1 237 ? -27.04500 47.10300  13.30100  1.000 44.47999  ? 217  ALA A N     1 
ATOM   1640 C CA    . ALA A 1 237 ? -26.53900 48.10900  14.23600  1.000 44.50048  ? 217  ALA A CA    1 
ATOM   1641 C C     . ALA A 1 237 ? -25.26100 48.75100  13.71600  1.000 43.58782  ? 217  ALA A C     1 
ATOM   1642 O O     . ALA A 1 237 ? -25.02700 49.95200  13.91200  1.000 41.15873  ? 217  ALA A O     1 
ATOM   1643 C CB    . ALA A 1 237 ? -26.30000 47.48200  15.60900  1.000 48.14700  ? 217  ALA A CB    1 
ATOM   1644 N N     . TRP A 1 238 ? -24.41800 47.96700  13.03500  1.000 39.64781  ? 218  TRP A N     1 
ATOM   1645 C CA    . TRP A 1 238 ? -23.19000 48.53400  12.49900  1.000 38.90448  ? 218  TRP A CA    1 
ATOM   1646 C C     . TRP A 1 238 ? -23.47000 49.42200  11.29100  1.000 36.84754  ? 218  TRP A C     1 
ATOM   1647 O O     . TRP A 1 238 ? -22.84900 50.48200  11.12800  1.000 36.61523  ? 218  TRP A O     1 
ATOM   1648 C CB    . TRP A 1 238 ? -22.22400 47.39900  12.17000  1.000 37.05916  ? 218  TRP A CB    1 
ATOM   1649 C CG    . TRP A 1 238 ? -21.50300 46.95600  13.42200  1.000 38.92246  ? 218  TRP A CG    1 
ATOM   1650 C CD1   . TRP A 1 238 ? -21.82000 45.89000  14.23800  1.000 40.28561  ? 218  TRP A CD1   1 
ATOM   1651 C CD2   . TRP A 1 238 ? -20.37300 47.59300  14.01400  1.000 36.65525  ? 218  TRP A CD2   1 
ATOM   1652 N NE1   . TRP A 1 238 ? -20.92000 45.81900  15.29000  1.000 37.57725  ? 218  TRP A NE1   1 
ATOM   1653 C CE2   . TRP A 1 238 ? -20.03000 46.85700  15.17600  1.000 39.67016  ? 218  TRP A CE2   1 
ATOM   1654 C CE3   . TRP A 1 238 ? -19.60100 48.70400  13.67100  1.000 36.41770  ? 218  TRP A CE3   1 
ATOM   1655 C CZ2   . TRP A 1 238 ? -18.95300 47.20600  15.98300  1.000 37.51280  ? 218  TRP A CZ2   1 
ATOM   1656 C CZ3   . TRP A 1 238 ? -18.54000 49.04200  14.47700  1.000 37.95923  ? 218  TRP A CZ3   1 
ATOM   1657 C CH2   . TRP A 1 238 ? -18.21700 48.28900  15.61600  1.000 34.86782  ? 218  TRP A CH2   1 
ATOM   1658 N N     . LYS A 1 239 ? -24.41000 49.02200  10.44200  1.000 36.39480  ? 219  LYS A N     1 
ATOM   1659 C CA    . LYS A 1 239 ? -24.76400 49.88800  9.32600   1.000 39.81515  ? 219  LYS A CA    1 
ATOM   1660 C C     . LYS A 1 239 ? -25.22400 51.25800  9.83000   1.000 42.52672  ? 219  LYS A C     1 
ATOM   1661 O O     . LYS A 1 239 ? -24.80300 52.30000  9.30200   1.000 35.53249  ? 219  LYS A O     1 
ATOM   1662 C CB    . LYS A 1 239 ? -25.83300 49.20800  8.47000   1.000 38.60561  ? 219  LYS A CB    1 
ATOM   1663 C CG    . LYS A 1 239 ? -25.46600 47.83100  7.90200   1.000 34.92408  ? 219  LYS A CG    1 
ATOM   1664 C CD    . LYS A 1 239 ? -26.56900 47.37100  6.94100   1.000 38.33086  ? 219  LYS A CD    1 
ATOM   1665 C CE    . LYS A 1 239 ? -26.44600 45.90400  6.61200   1.000 39.07572  ? 219  LYS A CE    1 
ATOM   1666 N NZ    . LYS A 1 239 ? -27.47900 45.45700  5.63700   1.000 43.40416  ? 219  LYS A NZ    1 
ATOM   1667 N N     . ARG A 1 240 ? -26.00400 51.28300  10.92300  1.000 43.39387  ? 220  ARG A N     1 
ATOM   1668 C CA    . ARG A 1 240 ? -26.51500 52.55400  11.44900  1.000 42.74499  ? 220  ARG A CA    1 
ATOM   1669 C C     . ARG A 1 240 ? -25.40300 53.42700  12.00400  1.000 43.26255  ? 220  ARG A C     1 
ATOM   1670 O O     . ARG A 1 240 ? -25.44300 54.65600  11.85800  1.000 42.85597  ? 220  ARG A O     1 
ATOM   1671 C CB    . ARG A 1 240 ? -27.54100 52.30900  12.55500  1.000 49.44200  ? 220  ARG A CB    1 
ATOM   1672 C CG    . ARG A 1 240 ? -28.90900 51.95300  12.09600  1.000 52.01842  ? 220  ARG A CG    1 
ATOM   1673 C CD    . ARG A 1 240 ? -29.92400 52.25400  13.22500  1.000 58.09877  ? 220  ARG A CD    1 
ATOM   1674 N NE    . ARG A 1 240 ? -29.37300 51.97300  14.55500  1.000 59.40097  ? 220  ARG A NE    1 
ATOM   1675 C CZ    . ARG A 1 240 ? -29.42400 50.78800  15.17700  1.000 59.78422  ? 220  ARG A CZ    1 
ATOM   1676 N NH1   . ARG A 1 240 ? -30.01100 49.72600  14.60700  1.000 55.18520  ? 220  ARG A NH1   1 
ATOM   1677 N NH2   . ARG A 1 240 ? -28.88500 50.66100  16.38400  1.000 54.21813  ? 220  ARG A NH2   1 
ATOM   1678 N N     . ARG A 1 241 ? -24.42600 52.81800  12.68600  1.000 42.50658  ? 221  ARG A N     1 
ATOM   1679 C CA    . ARG A 1 241 ? -23.31700 53.58700  13.23600  1.000 40.97240  ? 221  ARG A CA    1 
ATOM   1680 C C     . ARG A 1 241 ? -22.56000 54.32300  12.15100  1.000 40.21885  ? 221  ARG A C     1 
ATOM   1681 O O     . ARG A 1 241 ? -21.91300 55.33500  12.42800  1.000 39.19304  ? 221  ARG A O     1 
ATOM   1682 C CB    . ARG A 1 241 ? -22.33000 52.67900  13.97100  1.000 42.88953  ? 221  ARG A CB    1 
ATOM   1683 C CG    . ARG A 1 241 ? -22.68700 52.27500  15.37300  1.000 49.63875  ? 221  ARG A CG    1 
ATOM   1684 C CD    . ARG A 1 241 ? -21.48900 51.53800  16.00500  1.000 46.39675  ? 221  ARG A CD    1 
ATOM   1685 N NE    . ARG A 1 241 ? -21.78600 51.03200  17.34100  1.000 48.59065  ? 221  ARG A NE    1 
ATOM   1686 C CZ    . ARG A 1 241 ? -22.28000 49.82200  17.59200  1.000 52.96614  ? 221  ARG A CZ    1 
ATOM   1687 N NH1   . ARG A 1 241 ? -22.53000 48.97600  16.60100  1.000 49.52462  ? 221  ARG A NH1   1 
ATOM   1688 N NH2   . ARG A 1 241 ? -22.52100 49.44500  18.84400  1.000 62.49303  ? 221  ARG A NH2   1 
ATOM   1689 N N     . ALA A 1 242 ? -22.56200 53.79500  10.93000  1.000 39.77272  ? 222  ALA A N     1 
ATOM   1690 C CA    . ALA A 1 242 ? -21.72300 54.37000  9.89500   1.000 39.37279  ? 222  ALA A CA    1 
ATOM   1691 C C     . ALA A 1 242 ? -22.26600 55.73100  9.47200   1.000 34.95003  ? 222  ALA A C     1 
ATOM   1692 O O     . ALA A 1 242 ? -23.48000 55.93800  9.40700   1.000 33.79457  ? 222  ALA A O     1 
ATOM   1693 C CB    . ALA A 1 242 ? -21.66900 53.43100  8.68700   1.000 33.68121  ? 222  ALA A CB    1 
ATOM   1694 N N     . GLN A 1 243 ? -21.35500 56.65200  9.15800   1.000 33.22216  ? 223  GLN A N     1 
ATOM   1695 C CA    . GLN A 1 243 ? -21.76000 57.91500  8.54200   1.000 36.29334  ? 223  GLN A CA    1 
ATOM   1696 C C     . GLN A 1 243 ? -22.36100 57.70100  7.15900   1.000 38.54214  ? 223  GLN A C     1 
ATOM   1697 O O     . GLN A 1 243 ? -23.28400 58.42400  6.76500   1.000 34.75145  ? 223  GLN A O     1 
ATOM   1698 C CB    . GLN A 1 243 ? -20.57500 58.86200  8.43000   1.000 36.21377  ? 223  GLN A CB    1 
ATOM   1699 C CG    . GLN A 1 243 ? -20.39400 59.69700  9.65300   1.000 43.38000  ? 223  GLN A CG    1 
ATOM   1700 C CD    . GLN A 1 243 ? -19.34500 60.74600  9.45700   1.000 46.67247  ? 223  GLN A CD    1 
ATOM   1701 O OE1   . GLN A 1 243 ? -19.13900 61.22900  8.34000   1.000 51.90704  ? 223  GLN A OE1   1 
ATOM   1702 N NE2   . GLN A 1 243 ? -18.65300 61.10300  10.53900  1.000 52.65272  ? 223  GLN A NE2   1 
ATOM   1703 N N     . VAL A 1 244 ? -21.79000 56.73500  6.43600   1.000 32.11950  ? 224  VAL A N     1 
ATOM   1704 C CA    . VAL A 1 244 ? -22.23400 56.46100  5.04400   1.000 32.02168  ? 224  VAL A CA    1 
ATOM   1705 C C     . VAL A 1 244 ? -22.18500 54.95300  4.77600   1.000 30.91637  ? 224  VAL A C     1 
ATOM   1706 O O     . VAL A 1 244 ? -21.32800 54.28100  5.35000   1.000 30.31262  ? 224  VAL A O     1 
ATOM   1707 C CB    . VAL A 1 244 ? -21.37700 57.25000  4.03400   1.000 36.37924  ? 224  VAL A CB    1 
ATOM   1708 C CG1   . VAL A 1 244 ? -19.89100 56.98600  4.20300   1.000 37.18375  ? 224  VAL A CG1   1 
ATOM   1709 C CG2   . VAL A 1 244 ? -21.81300 57.02700  2.59300   1.000 34.96908  ? 224  VAL A CG2   1 
ATOM   1710 N N     . ARG A 1 245 ? -23.13400 54.46400  3.99000   1.000 31.64757  ? 225  ARG A N     1 
ATOM   1711 C CA    . ARG A 1 245 ? -23.12900 53.05000  3.56100   1.000 31.59902  ? 225  ARG A CA    1 
ATOM   1712 C C     . ARG A 1 245 ? -22.79100 53.06000  2.06000   1.000 30.50761  ? 225  ARG A C     1 
ATOM   1713 O O     . ARG A 1 245 ? -23.52900 53.69700  1.29800   1.000 30.71462  ? 225  ARG A O     1 
ATOM   1714 C CB    . ARG A 1 245 ? -24.45500 52.37900  3.92400   1.000 32.29967  ? 225  ARG A CB    1 
ATOM   1715 C CG    . ARG A 1 245 ? -24.69000 52.20100  5.41400   1.000 37.26099  ? 225  ARG A CG    1 
ATOM   1716 C CD    . ARG A 1 245 ? -26.04600 52.75000  5.81100   1.000 38.61924  ? 225  ARG A CD    1 
ATOM   1717 N NE    . ARG A 1 245 ? -26.09600 54.20800  5.67500   1.000 42.53807  ? 225  ARG A NE    1 
ATOM   1718 C CZ    . ARG A 1 245 ? -25.65000 55.05900  6.58600   1.000 44.91875  ? 225  ARG A CZ    1 
ATOM   1719 N NH1   . ARG A 1 245 ? -25.31200 54.62800  7.78600   1.000 38.92033  ? 225  ARG A NH1   1 
ATOM   1720 N NH2   . ARG A 1 245 ? -25.54200 56.33900  6.29300   1.000 44.52033  ? 225  ARG A NH2   1 
ATOM   1721 N N     . VAL A 1 246 ? -21.70300 52.40700  1.68200   1.000 22.87206  ? 226  VAL A N     1 
ATOM   1722 C CA    . VAL A 1 246 ? -21.25900 52.41400  0.28400   1.000 23.93834  ? 226  VAL A CA    1 
ATOM   1723 C C     . VAL A 1 246 ? -21.40800 51.01600  -0.31000  1.000 26.82401  ? 226  VAL A C     1 
ATOM   1724 O O     . VAL A 1 246 ? -21.29000 49.99400  0.37900   1.000 24.93087  ? 226  VAL A O     1 
ATOM   1725 C CB    . VAL A 1 246 ? -19.80500 52.89800  0.12800   1.000 24.24117  ? 226  VAL A CB    1 
ATOM   1726 C CG1   . VAL A 1 246 ? -19.62700 54.36400  0.60400   1.000 26.11227  ? 226  VAL A CG1   1 
ATOM   1727 C CG2   . VAL A 1 246 ? -18.82900 51.95500  0.83100   1.000 24.64056  ? 226  VAL A CG2   1 
ATOM   1728 N N     . ARG A 1 247 ? -21.64300 51.01700  -1.60900  1.000 26.40834  ? 227  ARG A N     1 
ATOM   1729 C CA    . ARG A 1 247 ? -21.78000 49.74000  -2.31800  1.000 23.21095  ? 227  ARG A CA    1 
ATOM   1730 C C     . ARG A 1 247 ? -20.81100 49.69600  -3.49400  1.000 24.28467  ? 227  ARG A C     1 
ATOM   1731 O O     . ARG A 1 247 ? -20.45000 50.75000  -4.02000  1.000 24.90848  ? 227  ARG A O     1 
ATOM   1732 C CB    . ARG A 1 247 ? -23.18200 49.55600  -2.90400  1.000 28.24923  ? 227  ARG A CB    1 
ATOM   1733 C CG    . ARG A 1 247 ? -23.54700 50.49100  -4.04600  1.000 27.66357  ? 227  ARG A CG    1 
ATOM   1734 C CD    . ARG A 1 247 ? -24.86100 50.11100  -4.70100  1.000 32.88706  ? 227  ARG A CD    1 
ATOM   1735 N NE    . ARG A 1 247 ? -25.15800 50.94900  -5.86700  1.000 32.65044  ? 227  ARG A NE    1 
ATOM   1736 C CZ    . ARG A 1 247 ? -25.60500 52.19400  -5.82000  1.000 44.01372  ? 227  ARG A CZ    1 
ATOM   1737 N NH1   . ARG A 1 247 ? -25.82900 52.78300  -4.66000  1.000 40.16267  ? 227  ARG A NH1   1 
ATOM   1738 N NH2   . ARG A 1 247 ? -25.83600 52.84900  -6.94000  1.000 45.06842  ? 227  ARG A NH2   1 
ATOM   1739 N N     . ILE A 1 248 ? -20.39400 48.49500  -3.83000  1.000 25.52935  ? 228  ILE A N     1 
ATOM   1740 C CA    . ILE A 1 248 ? -19.59400 48.28900  -5.05400  1.000 25.17933  ? 228  ILE A CA    1 
ATOM   1741 C C     . ILE A 1 248 ? -20.59800 47.74800  -6.08400  1.000 24.89528  ? 228  ILE A C     1 
ATOM   1742 O O     . ILE A 1 248 ? -21.32000 46.79700  -5.77900  1.000 21.80071  ? 228  ILE A O     1 
ATOM   1743 C CB    . ILE A 1 248 ? -18.44300 47.30700  -4.80300  1.000 25.07077  ? 228  ILE A CB    1 
ATOM   1744 C CG1   . ILE A 1 248 ? -17.49900 47.86400  -3.73800  1.000 25.95242  ? 228  ILE A CG1   1 
ATOM   1745 C CG2   . ILE A 1 248 ? -17.71000 46.97300  -6.09700  1.000 23.84540  ? 228  ILE A CG2   1 
ATOM   1746 C CD1   . ILE A 1 248 ? -16.32000 46.97300  -3.41900  1.000 26.79200  ? 228  ILE A CD1   1 
ATOM   1747 N N     . PRO A 1 249 ? -20.69200 48.36500  -7.26900  1.000 23.29607  ? 229  PRO A N     1 
ATOM   1748 C CA    . PRO A 1 249 ? -21.69200 47.94400  -8.22700  1.000 25.48327  ? 229  PRO A CA    1 
ATOM   1749 C C     . PRO A 1 249 ? -21.55400 46.49400  -8.65900  1.000 25.21307  ? 229  PRO A C     1 
ATOM   1750 O O     . PRO A 1 249 ? -20.43800 45.99800  -8.79700  1.000 24.50640  ? 229  PRO A O     1 
ATOM   1751 C CB    . PRO A 1 249 ? -21.45800 48.94400  -9.36800  1.000 32.34615  ? 229  PRO A CB    1 
ATOM   1752 C CG    . PRO A 1 249 ? -20.04700 49.42500  -9.18500  1.000 29.59241  ? 229  PRO A CG    1 
ATOM   1753 C CD    . PRO A 1 249 ? -19.86100 49.46800  -7.69100  1.000 28.08009  ? 229  PRO A CD    1 
ATOM   1754 N N     . MET A 1 250 ? -22.69200 45.81300  -8.80600  1.000 23.72308  ? 230  MET A N     1 
ATOM   1755 C CA    . MET A 1 250 ? -22.69800 44.40400  -9.28100  1.000 27.00389  ? 230  MET A CA    1 
ATOM   1756 C C     . MET A 1 250 ? -23.41100 44.39600  -10.63900 1.000 30.14789  ? 230  MET A C     1 
ATOM   1757 O O     . MET A 1 250 ? -24.57000 44.79300  -10.68900 1.000 31.25093  ? 230  MET A O     1 
ATOM   1758 C CB    . MET A 1 250 ? -23.35100 43.45800  -8.26700  1.000 30.09511  ? 230  MET A CB    1 
ATOM   1759 C CG    . MET A 1 250 ? -22.81500 43.55000  -6.86100  1.000 26.69851  ? 230  MET A CG    1 
ATOM   1760 S SD    . MET A 1 250 ? -21.12600 42.93300  -6.78300  1.000 31.36228  ? 230  MET A SD    1 
ATOM   1761 C CE    . MET A 1 250 ? -21.28400 41.26100  -7.41900  1.000 29.53516  ? 230  MET A CE    1 
ATOM   1762 N N     . ARG A 1 251 ? -22.74800 43.91500  -11.67300 1.000 28.45091  ? 231  ARG A N     1 
ATOM   1763 C CA    . ARG A 1 251 ? -23.28400 44.07000  -13.02700 1.000 33.97725  ? 231  ARG A CA    1 
ATOM   1764 C C     . ARG A 1 251 ? -23.67600 42.74800  -13.65300 1.000 37.76204  ? 231  ARG A C     1 
ATOM   1765 O O     . ARG A 1 251 ? -24.00200 42.71700  -14.84700 1.000 40.90942  ? 231  ARG A O     1 
ATOM   1766 C CB    . ARG A 1 251 ? -22.27300 44.75800  -13.94400 1.000 30.65175  ? 231  ARG A CB    1 
ATOM   1767 C CG    . ARG A 1 251 ? -21.81100 46.11000  -13.47900 1.000 36.67713  ? 231  ARG A CG    1 
ATOM   1768 C CD    . ARG A 1 251 ? -22.88200 47.13500  -13.68900 1.000 44.06182  ? 231  ARG A CD    1 
ATOM   1769 N NE    . ARG A 1 251 ? -22.50800 48.41000  -13.07600 1.000 50.35633  ? 231  ARG A NE    1 
ATOM   1770 C CZ    . ARG A 1 251 ? -21.92400 49.41300  -13.73700 1.000 54.40700  ? 231  ARG A CZ    1 
ATOM   1771 N NH1   . ARG A 1 251 ? -21.65700 49.28500  -15.04400 1.000 51.87170  ? 231  ARG A NH1   1 
ATOM   1772 N NH2   . ARG A 1 251 ? -21.60500 50.54300  -13.09600 1.000 52.21174  ? 231  ARG A NH2   1 
ATOM   1773 N N     . GLY A 1 252 ? -23.60600 41.65000  -12.91000 1.000 34.12634  ? 232  GLY A N     1 
ATOM   1774 C CA    . GLY A 1 252 ? -23.80800 40.34400  -13.50600 1.000 33.49676  ? 232  GLY A CA    1 
ATOM   1775 C C     . GLY A 1 252 ? -24.86600 39.60100  -12.72400 1.000 37.68976  ? 232  GLY A C     1 
ATOM   1776 O O     . GLY A 1 252 ? -25.81500 40.19100  -12.19000 1.000 38.09694  ? 232  GLY A O     1 
ATOM   1777 N N     . ARG A 1 253 ? -24.66800 38.28400  -12.61900 1.000 35.71031  ? 233  ARG A N     1 
ATOM   1778 C CA    . ARG A 1 253 ? -25.61100 37.45200  -11.87300 1.000 38.57525  ? 233  ARG A CA    1 
ATOM   1779 C C     . ARG A 1 253 ? -25.29100 37.40600  -10.38200 1.000 39.67705  ? 233  ARG A C     1 
ATOM   1780 O O     . ARG A 1 253 ? -26.21400 37.37400  -9.55300  1.000 40.97838  ? 233  ARG A O     1 
ATOM   1781 C CB    . ARG A 1 253 ? -25.62400 36.03100  -12.44700 1.000 41.11328  ? 233  ARG A CB    1 
ATOM   1782 C CG    . ARG A 1 253 ? -25.69800 35.96400  -13.97600 1.000 45.41269  ? 233  ARG A CG    1 
ATOM   1783 C CD    . ARG A 1 253 ? -26.98500 36.55800  -14.56300 1.000 45.18062  ? 233  ARG A CD    1 
ATOM   1784 N N     . ALA A 1 254 ? -24.01300 37.49900  -10.03700 1.000 40.79585  ? 234  ALA A N     1 
ATOM   1785 C CA    . ALA A 1 254 ? -23.62200 37.47900  -8.60900  1.000 37.85693  ? 234  ALA A CA    1 
ATOM   1786 C C     . ALA A 1 254 ? -24.30500 38.61300  -7.84800  1.000 33.23409  ? 234  ALA A C     1 
ATOM   1787 O O     . ALA A 1 254 ? -24.34200 39.73700  -8.34300  1.000 32.88190  ? 234  ALA A O     1 
ATOM   1788 C CB    . ALA A 1 254 ? -22.12300 37.53900  -8.45700  1.000 34.39004  ? 234  ALA A CB    1 
ATOM   1789 N N     . ASP A 1 255 ? -24.81600 38.30300  -6.66900  1.000 34.48476  ? 235  ASP A N     1 
ATOM   1790 C CA    . ASP A 1 255 ? -25.41400 39.31100  -5.80200  1.000 31.75555  ? 235  ASP A CA    1 
ATOM   1791 C C     . ASP A 1 255 ? -24.38800 40.09300  -4.96100  1.000 30.94496  ? 235  ASP A C     1 
ATOM   1792 O O     . ASP A 1 255 ? -24.67500 41.20400  -4.50000  1.000 35.08917  ? 235  ASP A O     1 
ATOM   1793 C CB    . ASP A 1 255 ? -26.36000 38.62200  -4.83000  1.000 34.82698  ? 235  ASP A CB    1 
ATOM   1794 C CG    . ASP A 1 255 ? -25.62900 37.64600  -3.95700  1.000 38.12547  ? 235  ASP A CG    1 
ATOM   1795 O OD1   . ASP A 1 255 ? -25.49500 36.46200  -4.35100  1.000 39.10786  ? 235  ASP A OD1   1 
ATOM   1796 O OD2   . ASP A 1 255 ? -25.11000 38.07800  -2.91200  1.000 39.22904  ? 235  ASP A OD2   1 
ATOM   1797 N N     . SER A 1 256 ? -23.24500 39.50800  -4.64700  1.000 31.09082  ? 236  SER A N     1 
ATOM   1798 C CA    . SER A 1 256 ? -22.29700 40.16600  -3.75500  1.000 27.63317  ? 236  SER A CA    1 
ATOM   1799 C C     . SER A 1 256 ? -20.94200 39.72000  -4.20600  1.000 27.61643  ? 236  SER A C     1 
ATOM   1800 O O     . SER A 1 256 ? -20.82100 38.73800  -4.94300  1.000 26.52672  ? 236  SER A O     1 
ATOM   1801 C CB    . SER A 1 256 ? -22.49900 39.79400  -2.29200  1.000 28.20529  ? 236  SER A CB    1 
ATOM   1802 O OG    . SER A 1 256 ? -22.29400 38.40500  -2.16600  1.000 31.68128  ? 236  SER A OG    1 
ATOM   1803 N N     . LEU A 1 257 ? -19.92300 40.43500  -3.74200  1.000 25.13389  ? 237  LEU A N     1 
ATOM   1804 C CA    . LEU A 1 257 ? -18.54200 40.02800  -4.05900  1.000 24.79223  ? 237  LEU A CA    1 
ATOM   1805 C C     . LEU A 1 257 ? -17.94000 39.31300  -2.85100  1.000 21.99095  ? 237  LEU A C     1 
ATOM   1806 O O     . LEU A 1 257 ? -18.50700 39.39200  -1.76900  1.000 25.09766  ? 237  LEU A O     1 
ATOM   1807 C CB    . LEU A 1 257 ? -17.65600 41.21900  -4.41400  1.000 25.48414  ? 237  LEU A CB    1 
ATOM   1808 C CG    . LEU A 1 257 ? -17.97400 41.98100  -5.70200  1.000 29.65867  ? 237  LEU A CG    1 
ATOM   1809 C CD1   . LEU A 1 257 ? -17.36800 43.36500  -5.62000  1.000 26.26055  ? 237  LEU A CD1   1 
ATOM   1810 C CD2   . LEU A 1 257 ? -17.44300 41.24500  -6.91500  1.000 30.89710  ? 237  LEU A CD2   1 
ATOM   1811 N N     . ASN A 1 258 ? -16.80900 38.67300  -3.06700  1.000 21.76874  ? 238  ASN A N     1 
ATOM   1812 C CA    . ASN A 1 258 ? -16.05500 38.07000  -1.94700  1.000 26.67911  ? 238  ASN A CA    1 
ATOM   1813 C C     . ASN A 1 258 ? -15.62700 39.20400  -1.00200  1.000 23.69152  ? 238  ASN A C     1 
ATOM   1814 O O     . ASN A 1 258 ? -15.37800 40.31100  -1.48200  1.000 20.61184  ? 238  ASN A O     1 
ATOM   1815 C CB    . ASN A 1 258 ? -14.91600 37.23400  -2.51000  1.000 24.44652  ? 238  ASN A CB    1 
ATOM   1816 C CG    . ASN A 1 258 ? -13.86600 36.88600  -1.49000  1.000 25.66385  ? 238  ASN A CG    1 
ATOM   1817 O OD1   . ASN A 1 258 ? -12.94900 37.67600  -1.25900  1.000 27.96418  ? 238  ASN A OD1   1 
ATOM   1818 N ND2   . ASN A 1 258 ? -13.97700 35.71100  -0.89300  1.000 23.26736  ? 238  ASN A ND2   1 
ATOM   1819 N N     . VAL A 1 259 ? -15.53300 38.91000  0.28800   1.000 21.29968  ? 239  VAL A N     1 
ATOM   1820 C CA    . VAL A 1 259 ? -15.23500 39.97100  1.29000   1.000 27.26554  ? 239  VAL A CA    1 
ATOM   1821 C C     . VAL A 1 259 ? -13.81300 40.53200  1.09400   1.000 20.10074  ? 239  VAL A C     1 
ATOM   1822 O O     . VAL A 1 259 ? -13.63000 41.72700  1.29900   1.000 21.67452  ? 239  VAL A O     1 
ATOM   1823 C CB    . VAL A 1 259 ? -15.47700 39.42500  2.71200   1.000 22.82128  ? 239  VAL A CB    1 
ATOM   1824 C CG1   . VAL A 1 259 ? -14.54500 38.27700  3.06500   1.000 24.15260  ? 239  VAL A CG1   1 
ATOM   1825 C CG2   . VAL A 1 259 ? -15.46200 40.53100  3.75700   1.000 26.93316  ? 239  VAL A CG2   1 
ATOM   1826 N N     . ALA A 1 260 ? -12.86900 39.69200  0.69500   1.000 22.41400  ? 240  ALA A N     1 
ATOM   1827 C CA    . ALA A 1 260 ? -11.47000 40.14700  0.52300   1.000 20.66115  ? 240  ALA A CA    1 
ATOM   1828 C C     . ALA A 1 260 ? -11.37000 41.01400  -0.72900  1.000 24.71732  ? 240  ALA A C     1 
ATOM   1829 O O     . ALA A 1 260 ? -10.68800 42.03900  -0.69700  1.000 23.41621  ? 240  ALA A O     1 
ATOM   1830 C CB    . ALA A 1 260 ? -10.55000 38.97500  0.46000   1.000 22.95982  ? 240  ALA A CB    1 
ATOM   1831 N N     . VAL A 1 261 ? -12.05600 40.60300  -1.79300  1.000 23.05941  ? 241  VAL A N     1 
ATOM   1832 C CA    . VAL A 1 261 ? -12.08700 41.43700  -3.02500  1.000 22.67998  ? 241  VAL A CA    1 
ATOM   1833 C C     . VAL A 1 261 ? -12.67800 42.80200  -2.64900  1.000 21.22378  ? 241  VAL A C     1 
ATOM   1834 O O     . VAL A 1 261 ? -12.12200 43.82200  -3.03800  1.000 21.87128  ? 241  VAL A O     1 
ATOM   1835 C CB    . VAL A 1 261 ? -12.87400 40.72800  -4.14500  1.000 25.22358  ? 241  VAL A CB    1 
ATOM   1836 C CG1   . VAL A 1 261 ? -13.36400 41.67900  -5.22300  1.000 21.54932  ? 241  VAL A CG1   1 
ATOM   1837 C CG2   . VAL A 1 261 ? -12.09800 39.56300  -4.74000  1.000 27.40706  ? 241  VAL A CG2   1 
ATOM   1838 N N     . THR A 1 262 ? -13.77000 42.78800  -1.89100  1.000 21.06967  ? 242  THR A N     1 
ATOM   1839 C CA    . THR A 1 262 ? -14.41700 44.04900  -1.48400  1.000 19.82621  ? 242  THR A CA    1 
ATOM   1840 C C     . THR A 1 262 ? -13.42500 44.91800  -0.71900  1.000 23.30392  ? 242  THR A C     1 
ATOM   1841 O O     . THR A 1 262 ? -13.24800 46.07500  -1.08200  1.000 20.11276  ? 242  THR A O     1 
ATOM   1842 C CB    . THR A 1 262 ? -15.68700 43.74000  -0.68800  1.000 20.96935  ? 242  THR A CB    1 
ATOM   1843 O OG1   . THR A 1 262 ? -16.54200 42.92800  -1.48300  1.000 23.76469  ? 242  THR A OG1   1 
ATOM   1844 C CG2   . THR A 1 262 ? -16.41100 45.01300  -0.28600  1.000 26.73496  ? 242  THR A CG2   1 
ATOM   1845 N N     . ALA A 1 263 ? -12.78700 44.35300  0.29600   1.000 21.17850  ? 243  ALA A N     1 
ATOM   1846 C CA    . ALA A 1 263 ? -11.79800 45.09700  1.10800   1.000 25.69902  ? 243  ALA A CA    1 
ATOM   1847 C C     . ALA A 1 263 ? -10.71500 45.71900  0.21800   1.000 23.51893  ? 243  ALA A C     1 
ATOM   1848 O O     . ALA A 1 263 ? -10.38700 46.88800  0.38800   1.000 22.31341  ? 243  ALA A O     1 
ATOM   1849 C CB    . ALA A 1 263 ? -11.20100 44.16100  2.11900   1.000 22.67713  ? 243  ALA A CB    1 
ATOM   1850 N N     . ALA A 1 264 ? -10.16900 44.92700  -0.69300  1.000 20.68785  ? 244  ALA A N     1 
ATOM   1851 C CA    . ALA A 1 264 ? -9.09300  45.42100  -1.58000  1.000 23.15083  ? 244  ALA A CA    1 
ATOM   1852 C C     . ALA A 1 264 ? -9.60100  46.59000  -2.42400  1.000 19.94630  ? 244  ALA A C     1 
ATOM   1853 O O     . ALA A 1 264 ? -8.91900  47.59200  -2.52900  1.000 20.68844  ? 244  ALA A O     1 
ATOM   1854 C CB    . ALA A 1 264 ? -8.58700  44.29600  -2.43800  1.000 24.02364  ? 244  ALA A CB    1 
ATOM   1855 N N     . LEU A 1 265 ? -10.79500 46.44000  -2.98200  1.000 21.00887  ? 245  LEU A N     1 
ATOM   1856 C CA    . LEU A 1 265 ? -11.38100 47.50000  -3.83400  1.000 23.24061  ? 245  LEU A CA    1 
ATOM   1857 C C     . LEU A 1 265 ? -11.51700 48.80100  -3.03000  1.000 23.77607  ? 245  LEU A C     1 
ATOM   1858 O O     . LEU A 1 265 ? -11.23000 49.86400  -3.55900  1.000 20.42839  ? 245  LEU A O     1 
ATOM   1859 C CB    . LEU A 1 265 ? -12.72300 46.99600  -4.35100  1.000 17.51440  ? 245  LEU A CB    1 
ATOM   1860 C CG    . LEU A 1 265 ? -12.67000 45.96100  -5.47900  1.000 20.96013  ? 245  LEU A CG    1 
ATOM   1861 C CD1   . LEU A 1 265 ? -14.05200 45.42100  -5.77700  1.000 21.39300  ? 245  LEU A CD1   1 
ATOM   1862 C CD2   . LEU A 1 265 ? -12.07000 46.56300  -6.72400  1.000 22.53568  ? 245  LEU A CD2   1 
ATOM   1863 N N     . LEU A 1 266 ? -11.95100 48.67700  -1.78000  1.000 21.16674  ? 246  LEU A N     1 
ATOM   1864 C CA    . LEU A 1 266 ? -12.13400 49.86900  -0.91600  1.000 21.12518  ? 246  LEU A CA    1 
ATOM   1865 C C     . LEU A 1 266 ? -10.76500 50.47800  -0.58400  1.000 18.42546  ? 246  LEU A C     1 
ATOM   1866 O O     . LEU A 1 266 ? -10.59900 51.68300  -0.72800  1.000 22.17517  ? 246  LEU A O     1 
ATOM   1867 C CB    . LEU A 1 266 ? -12.86800 49.45100  0.35000   1.000 24.33349  ? 246  LEU A CB    1 
ATOM   1868 C CG    . LEU A 1 266 ? -14.28600 48.91000  0.16400   1.000 21.55674  ? 246  LEU A CG    1 
ATOM   1869 C CD1   . LEU A 1 266 ? -14.73400 48.28800  1.46800   1.000 21.47493  ? 246  LEU A CD1   1 
ATOM   1870 C CD2   . LEU A 1 266 ? -15.22000 50.02100  -0.24700  1.000 20.62856  ? 246  LEU A CD2   1 
ATOM   1871 N N     . LEU A 1 267 ? -9.83600  49.62900  -0.16600  1.000 20.39481  ? 247  LEU A N     1 
ATOM   1872 C CA    . LEU A 1 267 ? -8.49500  50.12900  0.19400   1.000 23.63921  ? 247  LEU A CA    1 
ATOM   1873 C C     . LEU A 1 267 ? -7.87200  50.84600  -1.00400  1.000 22.13887  ? 247  LEU A C     1 
ATOM   1874 O O     . LEU A 1 267 ? -7.32600  51.93400  -0.83100  1.000 21.57585  ? 247  LEU A O     1 
ATOM   1875 C CB    . LEU A 1 267 ? -7.63900  48.94000  0.61600   1.000 21.48691  ? 247  LEU A CB    1 
ATOM   1876 C CG    . LEU A 1 267 ? -7.93800  48.34500  1.99400   1.000 23.63843  ? 247  LEU A CG    1 
ATOM   1877 C CD1   . LEU A 1 267 ? -7.20700  47.03200  2.14500   1.000 22.91532  ? 247  LEU A CD1   1 
ATOM   1878 C CD2   . LEU A 1 267 ? -7.53700  49.30200  3.09100   1.000 25.35726  ? 247  LEU A CD2   1 
ATOM   1879 N N     . TYR A 1 268 ? -7.95800  50.26600  -2.19500  1.000 22.24673  ? 248  TYR A N     1 
ATOM   1880 C CA    . TYR A 1 268 ? -7.24100  50.86600  -3.35800  1.000 20.87328  ? 248  TYR A CA    1 
ATOM   1881 C C     . TYR A 1 268 ? -7.97400  52.11200  -3.87200  1.000 23.02745  ? 248  TYR A C     1 
ATOM   1882 O O     . TYR A 1 268 ? -7.31500  52.97900  -4.42900  1.000 21.98478  ? 248  TYR A O     1 
ATOM   1883 C CB    . TYR A 1 268 ? -6.93300  49.77800  -4.38900  1.000 19.85202  ? 248  TYR A CB    1 
ATOM   1884 C CG    . TYR A 1 268 ? -5.63400  49.05600  -4.05600  1.000 21.50311  ? 248  TYR A CG    1 
ATOM   1885 C CD1   . TYR A 1 268 ? -4.40800  49.56800  -4.45500  1.000 20.71747  ? 248  TYR A CD1   1 
ATOM   1886 C CD2   . TYR A 1 268 ? -5.63100  47.88300  -3.31600  1.000 18.90351  ? 248  TYR A CD2   1 
ATOM   1887 C CE1   . TYR A 1 268 ? -3.22100  48.92800  -4.14500  1.000 21.23878  ? 248  TYR A CE1   1 
ATOM   1888 C CE2   . TYR A 1 268 ? -4.45200  47.23200  -3.00000  1.000 22.18686  ? 248  TYR A CE2   1 
ATOM   1889 C CZ    . TYR A 1 268 ? -3.24200  47.75400  -3.41800  1.000 23.34365  ? 248  TYR A CZ    1 
ATOM   1890 O OH    . TYR A 1 268 ? -2.07500  47.11800  -3.12000  1.000 25.68185  ? 248  TYR A OH    1 
ATOM   1891 N N     . GLU A 1 269 ? -9.28200  52.20400  -3.65800  1.000 21.91243  ? 249  GLU A N     1 
ATOM   1892 C CA    . GLU A 1 269 ? -9.98500  53.45800  -4.03800  1.000 20.87335  ? 249  GLU A CA    1 
ATOM   1893 C C     . GLU A 1 269 ? -9.46600  54.59400  -3.14400  1.000 23.24853  ? 249  GLU A C     1 
ATOM   1894 O O     . GLU A 1 269 ? -9.21600  55.69100  -3.64400  1.000 24.45106  ? 249  GLU A O     1 
ATOM   1895 C CB    . GLU A 1 269 ? -11.50100 53.33400  -3.92700  1.000 20.29434  ? 249  GLU A CB    1 
ATOM   1896 C CG    . GLU A 1 269 ? -12.25300 54.65700  -4.02600  1.000 22.08202  ? 249  GLU A CG    1 
ATOM   1897 C CD    . GLU A 1 269 ? -12.05200 55.42900  -5.31600  1.000 24.81492  ? 249  GLU A CD    1 
ATOM   1898 O OE1   . GLU A 1 269 ? -11.56900 54.85100  -6.30400  1.000 25.37373  ? 249  GLU A OE1   1 
ATOM   1899 O OE2   . GLU A 1 269 ? -12.38500 56.62400  -5.31900  1.000 26.95498  ? 249  GLU A OE2   1 
ATOM   1900 N N     . ALA A 1 270 ? -9.33000  54.30800  -1.85700  1.000 24.24544  ? 250  ALA A N     1 
ATOM   1901 C CA    . ALA A 1 270 ? -8.79000  55.30500  -0.90900  1.000 23.70865  ? 250  ALA A CA    1 
ATOM   1902 C C     . ALA A 1 270 ? -7.35600  55.67100  -1.29600  1.000 20.95592  ? 250  ALA A C     1 
ATOM   1903 O O     . ALA A 1 270 ? -7.01900  56.83700  -1.25800  1.000 24.96657  ? 250  ALA A O     1 
ATOM   1904 C CB    . ALA A 1 270 ? -8.85000  54.73500  0.47500   1.000 24.62331  ? 250  ALA A CB    1 
ATOM   1905 N N     . LEU A 1 271 ? -6.55300  54.67300  -1.64500  1.000 24.94075  ? 251  LEU A N     1 
ATOM   1906 C CA    . LEU A 1 271 ? -5.15300  54.93100  -2.06600  1.000 23.80316  ? 251  LEU A CA    1 
ATOM   1907 C C     . LEU A 1 271 ? -5.14800  55.80800  -3.33000  1.000 27.30598  ? 251  LEU A C     1 
ATOM   1908 O O     . LEU A 1 271 ? -4.35400  56.73800  -3.39700  1.000 28.85146  ? 251  LEU A O     1 
ATOM   1909 C CB    . LEU A 1 271 ? -4.37900  53.63700  -2.29200  1.000 24.71853  ? 251  LEU A CB    1 
ATOM   1910 C CG    . LEU A 1 271 ? -2.88300  53.78600  -2.57000  1.000 25.51452  ? 251  LEU A CG    1 
ATOM   1911 C CD1   . LEU A 1 271 ? -2.21700  54.59500  -1.47500  1.000 30.16207  ? 251  LEU A CD1   1 
ATOM   1912 C CD2   . LEU A 1 271 ? -2.22700  52.43000  -2.71600  1.000 23.04474  ? 251  LEU A CD2   1 
ATOM   1913 N N     . ARG A 1 272 ? -6.00400  55.48700  -4.29400  1.000 26.66546  ? 252  ARG A N     1 
ATOM   1914 C CA    . ARG A 1 272 ? -6.10200  56.30200  -5.52600  1.000 25.18787  ? 252  ARG A CA    1 
ATOM   1915 C C     . ARG A 1 272 ? -6.33800  57.76700  -5.14300  1.000 28.96658  ? 252  ARG A C     1 
ATOM   1916 O O     . ARG A 1 272 ? -5.65700  58.64900  -5.66600  1.000 22.97045  ? 252  ARG A O     1 
ATOM   1917 C CB    . ARG A 1 272 ? -7.27300  55.80500  -6.37900  1.000 24.38875  ? 252  ARG A CB    1 
ATOM   1918 C CG    . ARG A 1 272 ? -7.40400  56.53200  -7.70900  1.000 23.64900  ? 252  ARG A CG    1 
ATOM   1919 C CD    . ARG A 1 272 ? -8.68900  56.18100  -8.43100  1.000 23.16657  ? 252  ARG A CD    1 
ATOM   1920 N NE    . ARG A 1 272 ? -9.88200  56.69300  -7.75300  1.000 24.28323  ? 252  ARG A NE    1 
ATOM   1921 C CZ    . ARG A 1 272 ? -10.37700 57.91000  -7.89900  1.000 27.10770  ? 252  ARG A CZ    1 
ATOM   1922 N NH1   . ARG A 1 272 ? -9.78700  58.77800  -8.69500  1.000 25.43966  ? 252  ARG A NH1   1 
ATOM   1923 N NH2   . ARG A 1 272 ? -11.47000 58.25600  -7.25100  1.000 29.46405  ? 252  ARG A NH2   1 
ATOM   1924 N N     . GLN A 1 273 ? -7.31500  57.98100  -4.26800  1.000 25.68446  ? 253  GLN A N     1 
ATOM   1925 C CA    . GLN A 1 273 ? -7.66300  59.35600  -3.85700  1.000 25.12868  ? 253  GLN A CA    1 
ATOM   1926 C C     . GLN A 1 273 ? -6.45500  59.98300  -3.14600  1.000 28.35068  ? 253  GLN A C     1 
ATOM   1927 O O     . GLN A 1 273 ? -6.12000  61.13000  -3.43900  1.000 27.48047  ? 253  GLN A O     1 
ATOM   1928 C CB    . GLN A 1 273 ? -8.91200  59.28000  -2.98600  1.000 26.32815  ? 253  GLN A CB    1 
ATOM   1929 C CG    . GLN A 1 273 ? -10.20200 58.96300  -3.73000  1.000 28.92010  ? 253  GLN A CG    1 
ATOM   1930 C CD    . GLN A 1 273 ? -11.43000 59.12100  -2.85800  1.000 28.46374  ? 253  GLN A CD    1 
ATOM   1931 O OE1   . GLN A 1 273 ? -11.38200 59.74000  -1.79300  1.000 27.82688  ? 253  GLN A OE1   1 
ATOM   1932 N NE2   . GLN A 1 273 ? -12.54300 58.55900  -3.30100  1.000 27.09745  ? 253  GLN A NE2   1 
ATOM   1933 N N     . ARG A 1 274 ? -5.82100  59.22200  -2.26600  1.000 26.56942  ? 254  ARG A N     1 
ATOM   1934 C CA    . ARG A 1 274 ? -4.67500  59.75500  -1.49400  1.000 27.40015  ? 254  ARG A CA    1 
ATOM   1935 C C     . ARG A 1 274 ? -3.45700  59.96100  -2.41200  1.000 33.18421  ? 254  ARG A C     1 
ATOM   1936 O O     . ARG A 1 274 ? -2.52000  60.64900  -1.99200  1.000 30.75355  ? 254  ARG A O     1 
ATOM   1937 C CB    . ARG A 1 274 ? -4.39000  58.79200  -0.34200  1.000 31.91186  ? 254  ARG A CB    1 
ATOM   1938 C CG    . ARG A 1 274 ? -5.50900  58.86300  0.68800   1.000 28.65014  ? 254  ARG A CG    1 
ATOM   1939 C CD    . ARG A 1 274 ? -5.46000  57.77500  1.74400   1.000 31.85848  ? 254  ARG A CD    1 
ATOM   1940 N NE    . ARG A 1 274 ? -6.51500  57.91600  2.75300   1.000 31.69078  ? 254  ARG A NE    1 
ATOM   1941 C CZ    . ARG A 1 274 ? -6.32700  57.82200  4.06100   1.000 29.95438  ? 254  ARG A CZ    1 
ATOM   1942 N NH1   . ARG A 1 274 ? -5.15300  57.45500  4.53200   1.000 23.77115  ? 254  ARG A NH1   1 
ATOM   1943 N NH2   . ARG A 1 274 ? -7.31000  58.10000  4.89400   1.000 29.63221  ? 254  ARG A NH2   1 
ATOM   1944 N N     . SER A 1 275 ? -3.49100  59.37800  -3.60200  1.000 28.17494  ? 255  SER A N     1 
ATOM   1945 C CA    . SER A 1 275 ? -2.34500  59.47200  -4.53800  1.000 28.25813  ? 255  SER A CA    1 
ATOM   1946 C C     . SER A 1 275 ? -2.59900  60.57100  -5.58800  1.000 25.68081  ? 255  SER A C     1 
ATOM   1947 O O     . SER A 1 275 ? -1.79500  60.69200  -6.50400  1.000 30.74779  ? 255  SER A O     1 
ATOM   1948 C CB    . SER A 1 275 ? -2.04400  58.11500  -5.13300  1.000 23.58741  ? 255  SER A CB    1 
ATOM   1949 O OG    . SER A 1 275 ? -1.80200  57.14000  -4.13400  1.000 27.61305  ? 255  SER A OG    1 
ATOM   1950 N N     . GLY A 1 276 ? -3.68200  61.33100  -5.44300  1.000 23.87572  ? 256  GLY A N     1 
ATOM   1951 C CA    . GLY A 1 276 ? -3.94600  62.45400  -6.35800  1.000 31.26106  ? 256  GLY A CA    1 
ATOM   1952 C C     . GLY A 1 276 ? -5.31500  62.40800  -6.99900  1.000 28.70394  ? 256  GLY A C     1 
ATOM   1953 O O     . GLY A 1 276 ? -5.71800  63.40800  -7.59000  1.000 32.13272  ? 256  GLY A O     1 
ATOM   1954 N N     . GLY A 1 277 ? -6.01400  61.28500  -6.87300  1.000 27.95711  ? 257  GLY A N     1 
ATOM   1955 C CA    . GLY A 1 277 ? -7.30600  61.12900  -7.54800  1.000 24.13716  ? 257  GLY A CA    1 
ATOM   1956 C C     . GLY A 1 277 ? -8.44700  61.84100  -6.85900  1.000 29.38262  ? 257  GLY A C     1 
ATOM   1957 O O     . GLY A 1 277 ? -8.44500  61.96000  -5.63500  1.000 28.80719  ? 257  GLY A O     1 
ATOM   1958 N N     . ALA A 1 278 ? -9.42600  62.24900  -7.64900  1.000 29.22429  ? 258  ALA A N     1 
ATOM   1959 C CA    . ALA A 1 278 ? -10.61200 62.89200  -7.06600  1.000 30.94572  ? 258  ALA A CA    1 
ATOM   1960 C C     . ALA A 1 278 ? -11.73200 61.88700  -6.84600  1.000 30.59479  ? 258  ALA A C     1 
ATOM   1961 O O     . ALA A 1 278 ? -11.88100 60.94900  -7.63400  1.000 28.06628  ? 258  ALA A O     1 
ATOM   1962 C CB    . ALA A 1 278 ? -11.10900 63.97500  -7.98600  1.000 33.68226  ? 258  ALA A CB    1 
ATOM   1963 N N     . PRO A 1 279 ? -12.54700 62.07800  -5.79500  1.000 30.86969  ? 259  PRO A N     1 
ATOM   1964 C CA    . PRO A 1 279 ? -13.73700 61.27000  -5.64800  1.000 33.33462  ? 259  PRO A CA    1 
ATOM   1965 C C     . PRO A 1 279 ? -14.64400 61.50900  -6.85300  1.000 37.93561  ? 259  PRO A C     1 
ATOM   1966 O O     . PRO A 1 279 ? -14.54800 62.56200  -7.48900  1.000 37.01682  ? 259  PRO A O     1 
ATOM   1967 C CB    . PRO A 1 279 ? -14.33300 61.79400  -4.35600  1.000 31.23303  ? 259  PRO A CB    1 
ATOM   1968 C CG    . PRO A 1 279 ? -13.16000 62.38500  -3.61300  1.000 33.34492  ? 259  PRO A CG    1 
ATOM   1969 C CD    . PRO A 1 279 ? -12.30300 62.99100  -4.70200  1.000 33.13284  ? 259  PRO A CD    1 
ATOM   1970 N N     . LEU A 1 280 ? -15.51600 60.55200  -7.16300  1.000 36.22423  ? 260  LEU A N     1 
ATOM   1971 C CA    . LEU A 1 280 ? -16.45800 60.65300  -8.28900  1.000 38.65947  ? 260  LEU A CA    1 
ATOM   1972 C C     . LEU A 1 280 ? -17.61800 61.59600  -7.97000  1.000 40.27320  ? 260  LEU A C     1 
ATOM   1973 O O     . LEU A 1 280 ? -17.89900 61.81800  -6.80000  1.000 44.24718  ? 260  LEU A O     1 
ATOM   1974 C CB    . LEU A 1 280 ? -17.00700 59.27400  -8.67300  1.000 37.91426  ? 260  LEU A CB    1 
ATOM   1975 C CG    . LEU A 1 280 ? -17.81500 59.13700  -9.96500  1.000 41.06609  ? 260  LEU A CG    1 
ATOM   1976 C CD1   . LEU A 1 280 ? -16.91300 59.35500  -11.16400 1.000 44.15953  ? 260  LEU A CD1   1 
ATOM   1977 C CD2   . LEU A 1 280 ? -18.44500 57.76100  -10.06300 1.000 39.86798  ? 260  LEU A CD2   1 
ATOM   1978 N N     . MET B 1 21  ? -38.57200 3.92200   -4.55100  1.000 53.74886  ? 1    MET B N     1 
ATOM   1979 C CA    . MET B 1 21  ? -37.99400 4.99100   -5.40400  1.000 59.80121  ? 1    MET B CA    1 
ATOM   1980 C C     . MET B 1 21  ? -36.75800 5.58800   -4.70600  1.000 54.62768  ? 1    MET B C     1 
ATOM   1981 O O     . MET B 1 21  ? -35.80100 5.93800   -5.42000  1.000 51.44808  ? 1    MET B O     1 
ATOM   1982 C CB    . MET B 1 21  ? -39.02700 6.08500   -5.70300  1.000 59.76767  ? 1    MET B CB    1 
ATOM   1983 C CG    . MET B 1 21  ? -38.61200 7.06000   -6.78500  1.000 56.77983  ? 1    MET B CG    1 
ATOM   1984 S SD    . MET B 1 21  ? -38.54300 6.29700   -8.41700  1.000 78.96344  ? 1    MET B SD    1 
ATOM   1985 C CE    . MET B 1 21  ? -40.28300 5.92700   -8.68200  1.000 62.82099  ? 1    MET B CE    1 
ATOM   1986 N N     . ARG B 1 22  ? -36.76700 5.69000   -3.37400  1.000 50.10788  ? 2    ARG B N     1 
ATOM   1987 C CA    . ARG B 1 22  ? -35.61600 6.32300   -2.73200  1.000 47.49447  ? 2    ARG B CA    1 
ATOM   1988 C C     . ARG B 1 22  ? -34.34100 5.51800   -2.94200  1.000 47.22565  ? 2    ARG B C     1 
ATOM   1989 O O     . ARG B 1 22  ? -34.35100 4.28600   -2.95800  1.000 46.16646  ? 2    ARG B O     1 
ATOM   1990 C CB    . ARG B 1 22  ? -35.83200 6.47800   -1.23400  1.000 51.43684  ? 2    ARG B CB    1 
ATOM   1991 C CG    . ARG B 1 22  ? -36.80600 7.55600   -0.82900  1.000 51.22264  ? 2    ARG B CG    1 
ATOM   1992 C CD    . ARG B 1 22  ? -36.70400 7.84000   0.67500   1.000 56.37002  ? 2    ARG B CD    1 
ATOM   1993 N NE    . ARG B 1 22  ? -36.56300 6.63800   1.51000   1.000 59.91990  ? 2    ARG B NE    1 
ATOM   1994 C CZ    . ARG B 1 22  ? -37.50200 5.69500   1.66900   1.000 65.45607  ? 2    ARG B CZ    1 
ATOM   1995 N NH1   . ARG B 1 22  ? -38.67000 5.78000   1.02400   1.000 60.07268  ? 2    ARG B NH1   1 
ATOM   1996 N NH2   . ARG B 1 22  ? -37.27900 4.64800   2.47100   1.000 62.51397  ? 2    ARG B NH2   1 
ATOM   1997 N N     . ILE B 1 23  ? -33.21900 6.21600   -3.07300  1.000 40.91272  ? 3    ILE B N     1 
ATOM   1998 C CA    . ILE B 1 23  ? -31.93100 5.55000   -3.23700  1.000 38.17709  ? 3    ILE B CA    1 
ATOM   1999 C C     . ILE B 1 23  ? -31.17500 5.68800   -1.92600  1.000 46.31677  ? 3    ILE B C     1 
ATOM   2000 O O     . ILE B 1 23  ? -30.73300 6.78800   -1.56100  1.000 41.46477  ? 3    ILE B O     1 
ATOM   2001 C CB    . ILE B 1 23  ? -31.13600 6.10000   -4.42100  1.000 44.73569  ? 3    ILE B CB    1 
ATOM   2002 C CG1   . ILE B 1 23  ? -31.88100 5.77000   -5.72100  1.000 41.42126  ? 3    ILE B CG1   1 
ATOM   2003 C CG2   . ILE B 1 23  ? -29.74300 5.47300   -4.40900  1.000 41.92660  ? 3    ILE B CG2   1 
ATOM   2004 C CD1   . ILE B 1 23  ? -31.36900 6.41500   -6.94300  1.000 43.76930  ? 3    ILE B CD1   1 
ATOM   2005 N N     . GLU B 1 24  ? -31.03100 4.57300   -1.20200  1.000 38.85915  ? 4    GLU B N     1 
ATOM   2006 C CA    . GLU B 1 24  ? -30.53800 4.64100   0.17000   1.000 48.25374  ? 4    GLU B CA    1 
ATOM   2007 C C     . GLU B 1 24  ? -29.10100 4.17500   0.33700   1.000 44.89333  ? 4    GLU B C     1 
ATOM   2008 O O     . GLU B 1 24  ? -28.41100 4.65700   1.24200   1.000 46.46446  ? 4    GLU B O     1 
ATOM   2009 C CB    . GLU B 1 24  ? -31.44800 3.82200   1.10200   1.000 49.34920  ? 4    GLU B CB    1 
ATOM   2010 C CG    . GLU B 1 24  ? -32.90200 4.19400   0.94800   1.000 46.62363  ? 4    GLU B CG    1 
ATOM   2011 C CD    . GLU B 1 24  ? -33.47600 4.75100   2.21900   1.000 59.50728  ? 4    GLU B CD    1 
ATOM   2012 O OE1   . GLU B 1 24  ? -34.61100 4.34900   2.58200   1.000 61.58044  ? 4    GLU B OE1   1 
ATOM   2013 O OE2   . GLU B 1 24  ? -32.77900 5.57500   2.86600   1.000 62.37269  ? 4    GLU B OE2   1 
ATOM   2014 N N     . SER B 1 25  ? -28.64700 3.27700   -0.48600  1.000 48.82151  ? 5    SER B N     1 
ATOM   2015 C CA    . SER B 1 25  ? -27.33300 2.69100   -0.28700  1.000 52.48866  ? 5    SER B CA    1 
ATOM   2016 C C     . SER B 1 25  ? -26.29200 3.39600   -1.12900  1.000 45.75327  ? 5    SER B C     1 
ATOM   2017 O O     . SER B 1 25  ? -26.49200 3.56200   -2.34200  1.000 42.94444  ? 5    SER B O     1 
ATOM   2018 C CB    . SER B 1 25  ? -27.34900 1.21500   -0.65700  1.000 50.44479  ? 5    SER B CB    1 
ATOM   2019 O OG    . SER B 1 25  ? -26.02800 0.72400   -0.73100  1.000 53.75928  ? 5    SER B OG    1 
ATOM   2020 N N     . PRO B 1 26  ? -25.11400 3.76400   -0.56500  1.000 52.65067  ? 6    PRO B N     1 
ATOM   2021 C CA    . PRO B 1 26  ? -24.04200 4.32600   -1.37100  1.000 48.81481  ? 6    PRO B CA    1 
ATOM   2022 C C     . PRO B 1 26  ? -23.54400 3.37100   -2.41900  1.000 47.88685  ? 6    PRO B C     1 
ATOM   2023 O O     . PRO B 1 26  ? -22.80100 3.79000   -3.30900  1.000 52.41336  ? 6    PRO B O     1 
ATOM   2024 C CB    . PRO B 1 26  ? -22.95700 4.60700   -0.34500  1.000 50.29174  ? 6    PRO B CB    1 
ATOM   2025 C CG    . PRO B 1 26  ? -23.23400 3.63900   0.76700   1.000 54.40190  ? 6    PRO B CG    1 
ATOM   2026 C CD    . PRO B 1 26  ? -24.73300 3.74900   0.86400   1.000 50.75101  ? 6    PRO B CD    1 
ATOM   2027 N N     . GLN B 1 27  ? -23.94500 2.10900   -2.33000  1.000 48.28527  ? 7    GLN B N     1 
ATOM   2028 C CA    . GLN B 1 27  ? -23.39600 1.11300   -3.28400  1.000 51.66774  ? 7    GLN B CA    1 
ATOM   2029 C C     . GLN B 1 27  ? -24.37700 0.92500   -4.44800  1.000 50.86450  ? 7    GLN B C     1 
ATOM   2030 O O     . GLN B 1 27  ? -24.00500 0.26600   -5.42400  1.000 53.05009  ? 7    GLN B O     1 
ATOM   2031 C CB    . GLN B 1 27  ? -23.06000 -0.19400  -2.56900  1.000 56.68869  ? 7    GLN B CB    1 
ATOM   2032 C CG    . GLN B 1 27  ? -22.10200 -0.02800  -1.39700  1.000 60.09029  ? 7    GLN B CG    1 
ATOM   2033 C CD    . GLN B 1 27  ? -20.65100 0.02500   -1.82100  1.000 68.59238  ? 7    GLN B CD    1 
ATOM   2034 O OE1   . GLN B 1 27  ? -20.32200 0.00100   -3.01100  1.000 67.17192  ? 7    GLN B OE1   1 
ATOM   2035 N NE2   . GLN B 1 27  ? -19.76400 0.09500   -0.84100  1.000 74.18741  ? 7    GLN B NE2   1 
ATOM   2036 N N     . ASN B 1 28  ? -25.56900 1.50600   -4.35100  1.000 45.04128  ? 8    ASN B N     1 
ATOM   2037 C CA    . ASN B 1 28  ? -26.51800 1.40500   -5.44700  1.000 42.21942  ? 8    ASN B CA    1 
ATOM   2038 C C     . ASN B 1 28  ? -25.82800 1.79500   -6.75200  1.000 46.96170  ? 8    ASN B C     1 
ATOM   2039 O O     . ASN B 1 28  ? -25.07400 2.77600   -6.78500  1.000 48.20880  ? 8    ASN B O     1 
ATOM   2040 C CB    . ASN B 1 28  ? -27.72300 2.31000   -5.18100  1.000 43.72054  ? 8    ASN B CB    1 
ATOM   2041 C CG    . ASN B 1 28  ? -28.68300 2.38600   -6.35900  1.000 47.24476  ? 8    ASN B CG    1 
ATOM   2042 O OD1   . ASN B 1 28  ? -28.32500 2.83700   -7.44500  1.000 46.81117  ? 8    ASN B OD1   1 
ATOM   2043 N ND2   . ASN B 1 28  ? -29.92300 1.97000   -6.13500  1.000 46.70182  ? 8    ASN B ND2   1 
ATOM   2044 N N     . PRO B 1 29  ? -26.05200 1.05700   -7.83700  1.000 49.62231  ? 9    PRO B N     1 
ATOM   2045 C CA    . PRO B 1 29  ? -25.33000 1.35800   -9.08700  1.000 44.50256  ? 9    PRO B CA    1 
ATOM   2046 C C     . PRO B 1 29  ? -25.52700 2.77700   -9.59300  1.000 44.64322  ? 9    PRO B C     1 
ATOM   2047 O O     . PRO B 1 29  ? -24.62300 3.33100   -10.23400 1.000 46.96202  ? 9    PRO B O     1 
ATOM   2048 C CB    . PRO B 1 29  ? -25.90700 0.33300   -10.06700 1.000 43.34585  ? 9    PRO B CB    1 
ATOM   2049 C CG    . PRO B 1 29  ? -26.32000 -0.81800  -9.16600  1.000 48.36241  ? 9    PRO B CG    1 
ATOM   2050 C CD    . PRO B 1 29  ? -26.88000 -0.15500  -7.95100  1.000 48.45058  ? 9    PRO B CD    1 
ATOM   2051 N N     . ARG B 1 30  ? -26.68500 3.38600   -9.35100  1.000 42.72631  ? 10   ARG B N     1 
ATOM   2052 C CA    . ARG B 1 30  ? -26.88100 4.75500   -9.82200  1.000 44.27250  ? 10   ARG B CA    1 
ATOM   2053 C C     . ARG B 1 30  ? -25.96800 5.72900   -9.07900  1.000 43.93171  ? 10   ARG B C     1 
ATOM   2054 O O     . ARG B 1 30  ? -25.42100 6.66400   -9.68400  1.000 45.30707  ? 10   ARG B O     1 
ATOM   2055 C CB    . ARG B 1 30  ? -28.33900 5.15500   -9.66300  1.000 43.53853  ? 10   ARG B CB    1 
ATOM   2056 C CG    . ARG B 1 30  ? -28.69500 6.40200   -10.39700 1.000 48.27834  ? 10   ARG B CG    1 
ATOM   2057 C CD    . ARG B 1 30  ? -28.61000 6.21200   -11.90700 1.000 53.29457  ? 10   ARG B CD    1 
ATOM   2058 N NE    . ARG B 1 30  ? -29.06800 7.41700   -12.60700 1.000 54.21789  ? 10   ARG B NE    1 
ATOM   2059 C CZ    . ARG B 1 30  ? -30.35000 7.73400   -12.78400 1.000 53.30397  ? 10   ARG B CZ    1 
ATOM   2060 N NH1   . ARG B 1 30  ? -31.30000 6.93700   -12.31800 1.000 51.25895  ? 10   ARG B NH1   1 
ATOM   2061 N NH2   . ARG B 1 30  ? -30.68300 8.85700   -13.41600 1.000 56.60084  ? 10   ARG B NH2   1 
ATOM   2062 N N     . VAL B 1 31  ? -25.79500 5.52600   -7.77300  1.000 38.97534  ? 11   VAL B N     1 
ATOM   2063 C CA    . VAL B 1 31  ? -24.89000 6.36700   -7.00400  1.000 41.58160  ? 11   VAL B CA    1 
ATOM   2064 C C     . VAL B 1 31  ? -23.48400 6.27100   -7.56400  1.000 49.34303  ? 11   VAL B C     1 
ATOM   2065 O O     . VAL B 1 31  ? -22.77400 7.28500   -7.67100  1.000 40.63605  ? 11   VAL B O     1 
ATOM   2066 C CB    . VAL B 1 31  ? -24.92400 6.00100   -5.51300  1.000 42.22650  ? 11   VAL B CB    1 
ATOM   2067 C CG1   . VAL B 1 31  ? -23.81300 6.72900   -4.77700  1.000 44.96798  ? 11   VAL B CG1   1 
ATOM   2068 C CG2   . VAL B 1 31  ? -26.26900 6.36700   -4.90100  1.000 43.49919  ? 11   VAL B CG2   1 
ATOM   2069 N N     . LYS B 1 32  ? -23.10300 5.07000   -7.97900  1.000 45.73250  ? 12   LYS B N     1 
ATOM   2070 C CA    . LYS B 1 32  ? -21.75100 4.87100   -8.54400  1.000 46.10803  ? 12   LYS B CA    1 
ATOM   2071 C C     . LYS B 1 32  ? -21.60800 5.72400   -9.80300  1.000 41.04193  ? 12   LYS B C     1 
ATOM   2072 O O     . LYS B 1 32  ? -20.56500 6.36400   -9.97000  1.000 46.75774  ? 12   LYS B O     1 
ATOM   2073 C CB    . LYS B 1 32  ? -21.52800 3.39600   -8.87800  1.000 49.97596  ? 12   LYS B CB    1 
ATOM   2074 C CG    . LYS B 1 32  ? -21.40600 2.53200   -7.63100  1.000 57.37675  ? 12   LYS B CG    1 
ATOM   2075 C CD    . LYS B 1 32  ? -21.14100 1.05600   -7.89100  1.000 56.87011  ? 12   LYS B CD    1 
ATOM   2076 C CE    . LYS B 1 32  ? -20.97200 0.29200   -6.61700  1.000 62.45871  ? 12   LYS B CE    1 
ATOM   2077 N NZ    . LYS B 1 32  ? -20.01700 0.93400   -5.71200  1.000 59.31158  ? 12   LYS B NZ    1 
ATOM   2078 N N     . ALA B 1 33  ? -22.62300 5.70800   -10.65200 1.000 40.93492  ? 13   ALA B N     1 
ATOM   2079 C CA    . ALA B 1 33  ? -22.51700 6.46000   -11.88800 1.000 40.92581  ? 13   ALA B CA    1 
ATOM   2080 C C     . ALA B 1 33  ? -22.48300 7.96800   -11.63600 1.000 43.93533  ? 13   ALA B C     1 
ATOM   2081 O O     . ALA B 1 33  ? -21.85700 8.70800   -12.40700 1.000 43.07604  ? 13   ALA B O     1 
ATOM   2082 C CB    . ALA B 1 33  ? -23.67400 6.11100   -12.79800 1.000 38.11277  ? 13   ALA B CB    1 
ATOM   2083 N N     . LEU B 1 34  ? -23.18300 8.43800   -10.60000 1.000 38.72943  ? 14   LEU B N     1 
ATOM   2084 C CA    . LEU B 1 34  ? -23.23300 9.87000   -10.31400 1.000 41.38715  ? 14   LEU B CA    1 
ATOM   2085 C C     . LEU B 1 34  ? -21.92200 10.34800  -9.70800  1.000 42.59658  ? 14   LEU B C     1 
ATOM   2086 O O     . LEU B 1 34  ? -21.43200 11.43000  -10.05400 1.000 41.55842  ? 14   LEU B O     1 
ATOM   2087 C CB    . LEU B 1 34  ? -24.40200 10.18500  -9.37600  1.000 34.07845  ? 14   LEU B CB    1 
ATOM   2088 C CG    . LEU B 1 34  ? -25.78500 9.96100   -10.00400 1.000 37.59845  ? 14   LEU B CG    1 
ATOM   2089 C CD1   . LEU B 1 34  ? -26.88300 9.80400   -8.92300  1.000 38.36543  ? 14   LEU B CD1   1 
ATOM   2090 C CD2   . LEU B 1 34  ? -26.12100 11.07900  -10.94300 1.000 38.61785  ? 14   LEU B CD2   1 
ATOM   2091 N N     . ALA B 1 35  ? -21.35400 9.56000   -8.78700  1.000 39.71517  ? 15   ALA B N     1 
ATOM   2092 C CA    . ALA B 1 35  ? -20.08400 9.89100   -8.15600  1.000 41.82442  ? 15   ALA B CA    1 
ATOM   2093 C C     . ALA B 1 35  ? -18.92200 9.83700   -9.13600  1.000 41.75322  ? 15   ALA B C     1 
ATOM   2094 O O     . ALA B 1 35  ? -17.87900 10.44900  -8.87800  1.000 43.50590  ? 15   ALA B O     1 
ATOM   2095 C CB    . ALA B 1 35  ? -19.81100 8.95300   -6.98600  1.000 44.31483  ? 15   ALA B CB    1 
ATOM   2096 N N     . ALA B 1 36  ? -19.06500 9.11900   -10.24800 1.000 42.42916  ? 16   ALA B N     1 
ATOM   2097 C CA    . ALA B 1 36  ? -17.98900 9.09900   -11.23100 1.000 45.20451  ? 16   ALA B CA    1 
ATOM   2098 C C     . ALA B 1 36  ? -17.84800 10.42600  -11.96900 1.000 42.40894  ? 16   ALA B C     1 
ATOM   2099 O O     . ALA B 1 36  ? -16.80600 10.65900  -12.58000 1.000 43.42146  ? 16   ALA B O     1 
ATOM   2100 C CB    . ALA B 1 36  ? -18.21100 7.98900   -12.25200 1.000 43.29749  ? 16   ALA B CB    1 
ATOM   2101 N N     . LEU B 1 37  ? -18.88200 11.27300  -11.95200 1.000 42.57923  ? 17   LEU B N     1 
ATOM   2102 C CA    . LEU B 1 37  ? -18.82000 12.58300  -12.58500 1.000 45.63981  ? 17   LEU B CA    1 
ATOM   2103 C C     . LEU B 1 37  ? -17.83600 13.51500  -11.89100 1.000 42.80316  ? 17   LEU B C     1 
ATOM   2104 O O     . LEU B 1 37  ? -17.53800 14.59100  -12.42700 1.000 42.63971  ? 17   LEU B O     1 
ATOM   2105 C CB    . LEU B 1 37  ? -20.21200 13.22000  -12.60900 1.000 40.64157  ? 17   LEU B CB    1 
ATOM   2106 C CG    . LEU B 1 37  ? -21.20400 12.43700  -13.46600 1.000 41.36589  ? 17   LEU B CG    1 
ATOM   2107 C CD1   . LEU B 1 37  ? -22.62100 13.02700  -13.37100 1.000 36.74352  ? 17   LEU B CD1   1 
ATOM   2108 C CD2   . LEU B 1 37  ? -20.74000 12.36800  -14.90800 1.000 40.77440  ? 17   LEU B CD2   1 
ATOM   2109 N N     . LYS B 1 38  ? -17.34000 13.13600  -10.71600 1.000 38.78219  ? 18   LYS B N     1 
ATOM   2110 C CA    . LYS B 1 38  ? -16.27900 13.89700  -10.07500 1.000 41.98533  ? 18   LYS B CA    1 
ATOM   2111 C C     . LYS B 1 38  ? -15.01700 13.95200  -10.92500 1.000 44.60029  ? 18   LYS B C     1 
ATOM   2112 O O     . LYS B 1 38  ? -14.20400 14.86300  -10.74800 1.000 47.23385  ? 18   LYS B O     1 
ATOM   2113 C CB    . LYS B 1 38  ? -15.93600 13.29300  -8.71300  1.000 45.73492  ? 18   LYS B CB    1 
ATOM   2114 C CG    . LYS B 1 38  ? -16.95400 13.52600  -7.62200  1.000 44.10917  ? 18   LYS B CG    1 
ATOM   2115 C CD    . LYS B 1 38  ? -16.67300 12.53400  -6.49700  1.000 51.04011  ? 18   LYS B CD    1 
ATOM   2116 C CE    . LYS B 1 38  ? -17.50200 12.83700  -5.27400  1.000 48.22776  ? 18   LYS B CE    1 
ATOM   2117 N NZ    . LYS B 1 38  ? -17.03000 12.06500  -4.09300  1.000 50.65272  ? 18   LYS B NZ    1 
ATOM   2118 N N     . GLU B 1 39  ? -14.83200 13.01500  -11.84300 1.000 45.70903  ? 19   GLU B N     1 
ATOM   2119 C CA    . GLU B 1 39  ? -13.61600 12.98100  -12.64500 1.000 48.07108  ? 19   GLU B CA    1 
ATOM   2120 C C     . GLU B 1 39  ? -13.88000 13.62100  -13.99800 1.000 44.35610  ? 19   GLU B C     1 
ATOM   2121 O O     . GLU B 1 39  ? -14.89800 13.34000  -14.63900 1.000 43.11586  ? 19   GLU B O     1 
ATOM   2122 C CB    . GLU B 1 39  ? -13.09200 11.55200  -12.80400 1.000 44.39927  ? 19   GLU B CB    1 
ATOM   2123 C CG    . GLU B 1 39  ? -12.53100 10.95900  -11.48800 1.000 51.48878  ? 19   GLU B CG    1 
ATOM   2124 C CD    . GLU B 1 39  ? -11.26100 11.67100  -11.02300 1.000 64.90285  ? 19   GLU B CD    1 
ATOM   2125 O OE1   . GLU B 1 39  ? -11.07800 11.85800  -9.78900  1.000 63.24560  ? 19   GLU B OE1   1 
ATOM   2126 O OE2   . GLU B 1 39  ? -10.44800 12.05200  -11.90700 1.000 65.85476  ? 19   GLU B OE2   1 
ATOM   2127 N N     . ARG B 1 40  ? -12.95300 14.48900  -14.42300 1.000 47.36564  ? 20   ARG B N     1 
ATOM   2128 C CA    . ARG B 1 40  ? -13.13400 15.20100  -15.68400 1.000 43.62820  ? 20   ARG B CA    1 
ATOM   2129 C C     . ARG B 1 40  ? -13.30100 14.24400  -16.85400 1.000 37.62586  ? 20   ARG B C     1 
ATOM   2130 O O     . ARG B 1 40  ? -14.10100 14.50500  -17.76000 1.000 40.26742  ? 20   ARG B O     1 
ATOM   2131 C CB    . ARG B 1 40  ? -11.95200 16.14300  -15.95200 1.000 42.32107  ? 20   ARG B CB    1 
ATOM   2132 C CG    . ARG B 1 40  ? -12.11900 16.88200  -17.28400 1.000 43.26887  ? 20   ARG B CG    1 
ATOM   2133 C CD    . ARG B 1 40  ? -11.04400 17.95500  -17.52900 1.000 41.96262  ? 20   ARG B CD    1 
ATOM   2134 N NE    . ARG B 1 40  ? -11.46700 18.80000  -18.64400 1.000 41.52317  ? 20   ARG B NE    1 
ATOM   2135 C CZ    . ARG B 1 40  ? -10.71900 19.76600  -19.18000 1.000 39.90965  ? 20   ARG B CZ    1 
ATOM   2136 N NH1   . ARG B 1 40  ? -9.50400  19.99700  -18.70200 1.000 42.65278  ? 20   ARG B NH1   1 
ATOM   2137 N NH2   . ARG B 1 40  ? -11.18000 20.48400  -20.19600 1.000 36.38582  ? 20   ARG B NH2   1 
ATOM   2138 N N     . LYS B 1 41  ? -12.53800 13.14200  -16.88000 1.000 42.99196  ? 21   LYS B N     1 
ATOM   2139 C CA    . LYS B 1 41  ? -12.66700 12.20500  -18.00500 1.000 43.53602  ? 21   LYS B CA    1 
ATOM   2140 C C     . LYS B 1 41  ? -14.09300 11.68200  -18.13700 1.000 43.20322  ? 21   LYS B C     1 
ATOM   2141 O O     . LYS B 1 41  ? -14.62100 11.55800  -19.25300 1.000 42.58582  ? 21   LYS B O     1 
ATOM   2142 C CB    . LYS B 1 41  ? -11.69600 11.03500  -17.85600 1.000 46.36126  ? 21   LYS B CB    1 
ATOM   2143 N N     . GLU B 1 42  ? -14.74400 11.39400  -17.00500 1.000 46.53590  ? 22   GLU B N     1 
ATOM   2144 C CA    . GLU B 1 42  ? -16.11100 10.90100  -17.06200 1.000 41.56134  ? 22   GLU B CA    1 
ATOM   2145 C C     . GLU B 1 42  ? -17.06200 12.00200  -17.50800 1.000 45.14549  ? 22   GLU B C     1 
ATOM   2146 O O     . GLU B 1 42  ? -17.97800 11.75100  -18.30300 1.000 39.16426  ? 22   GLU B O     1 
ATOM   2147 C CB    . GLU B 1 42  ? -16.50500 10.33500  -15.70600 1.000 43.69128  ? 22   GLU B CB    1 
ATOM   2148 C CG    . GLU B 1 42  ? -17.90600 9.76600   -15.64800 1.000 48.00031  ? 22   GLU B CG    1 
ATOM   2149 C CD    . GLU B 1 42  ? -18.07800 8.40700   -16.36700 1.000 51.99210  ? 22   GLU B CD    1 
ATOM   2150 O OE1   . GLU B 1 42  ? -17.18700 7.97000   -17.13800 1.000 49.12111  ? 22   GLU B OE1   1 
ATOM   2151 O OE2   . GLU B 1 42  ? -19.14400 7.78600   -16.15100 1.000 47.34160  ? 22   GLU B OE2   1 
ATOM   2152 N N     . ARG B 1 43  ? -16.83700 13.24200  -17.03900 1.000 42.02080  ? 23   ARG B N     1 
ATOM   2153 C CA    . ARG B 1 43  ? -17.64500 14.35600  -17.52700 1.000 41.50864  ? 23   ARG B CA    1 
ATOM   2154 C C     . ARG B 1 43  ? -17.52400 14.49500  -19.03400 1.000 43.58873  ? 23   ARG B C     1 
ATOM   2155 O O     . ARG B 1 43  ? -18.52000 14.72400  -19.72500 1.000 42.48165  ? 23   ARG B O     1 
ATOM   2156 C CB    . ARG B 1 43  ? -17.23300 15.67100  -16.85100 1.000 41.52656  ? 23   ARG B CB    1 
ATOM   2157 C CG    . ARG B 1 43  ? -17.24400 15.63400  -15.36400 1.000 40.81979  ? 23   ARG B CG    1 
ATOM   2158 C CD    . ARG B 1 43  ? -17.22400 17.03000  -14.78100 1.000 42.97605  ? 23   ARG B CD    1 
ATOM   2159 N NE    . ARG B 1 43  ? -15.89500 17.63700  -14.68900 1.000 37.77136  ? 23   ARG B NE    1 
ATOM   2160 C CZ    . ARG B 1 43  ? -15.07100 17.51700  -13.64500 1.000 40.63970  ? 23   ARG B CZ    1 
ATOM   2161 N NH1   . ARG B 1 43  ? -15.38300 16.75300  -12.60800 1.000 39.56558  ? 23   ARG B NH1   1 
ATOM   2162 N NH2   . ARG B 1 43  ? -13.91600 18.16000  -13.63500 1.000 38.40185  ? 23   ARG B NH2   1 
ATOM   2163 N N     . GLU B 1 44  ? -16.29900 14.41500  -19.55500 1.000 43.53379  ? 24   GLU B N     1 
ATOM   2164 C CA    . GLU B 1 44  ? -16.11900 14.45400  -21.00200 1.000 51.51311  ? 24   GLU B CA    1 
ATOM   2165 C C     . GLU B 1 44  ? -16.80200 13.26300  -21.66000 1.000 50.45713  ? 24   GLU B C     1 
ATOM   2166 O O     . GLU B 1 44  ? -17.53300 13.41300  -22.65100 1.000 48.91802  ? 24   GLU B O     1 
ATOM   2167 C CB    . GLU B 1 44  ? -14.62300 14.49100  -21.35000 1.000 50.36365  ? 24   GLU B CB    1 
ATOM   2168 C CG    . GLU B 1 44  ? -13.96700 15.89100  -21.25700 1.000 53.91050  ? 24   GLU B CG    1 
ATOM   2169 C CD    . GLU B 1 44  ? -14.76200 16.96600  -22.01600 1.000 60.09281  ? 24   GLU B CD    1 
ATOM   2170 O OE1   . GLU B 1 44  ? -14.83200 18.12700  -21.54300 1.000 64.09351  ? 24   GLU B OE1   1 
ATOM   2171 O OE2   . GLU B 1 44  ? -15.33300 16.64500  -23.08500 1.000 66.63996  ? 24   GLU B OE2   1 
ATOM   2172 N N     . ARG B 1 45  ? -16.57600 12.06500  -21.10900 1.000 49.88724  ? 25   ARG B N     1 
ATOM   2173 C CA    . ARG B 1 45  ? -17.11200 10.85400  -21.72400 1.000 51.03060  ? 25   ARG B CA    1 
ATOM   2174 C C     . ARG B 1 45  ? -18.62700 10.93500  -21.86200 1.000 51.14806  ? 25   ARG B C     1 
ATOM   2175 O O     . ARG B 1 45  ? -19.17900 10.62000  -22.92300 1.000 58.02945  ? 25   ARG B O     1 
ATOM   2176 C CB    . ARG B 1 45  ? -16.70400 9.62400   -20.90300 1.000 54.07495  ? 25   ARG B CB    1 
ATOM   2177 C CG    . ARG B 1 45  ? -17.08700 8.27900   -21.55000 1.000 54.87212  ? 25   ARG B CG    1 
ATOM   2178 C CD    . ARG B 1 45  ? -16.80700 7.08300   -20.64100 1.000 56.01142  ? 25   ARG B CD    1 
ATOM   2179 N NE    . ARG B 1 45  ? -17.76400 6.97300   -19.53200 1.000 56.74805  ? 25   ARG B NE    1 
ATOM   2180 C CZ    . ARG B 1 45  ? -19.05300 6.65400   -19.67500 1.000 59.68179  ? 25   ARG B CZ    1 
ATOM   2181 N NH1   . ARG B 1 45  ? -19.56500 6.42100   -20.88000 1.000 63.76076  ? 25   ARG B NH1   1 
ATOM   2182 N NH2   . ARG B 1 45  ? -19.84300 6.57700   -18.60800 1.000 59.70941  ? 25   ARG B NH2   1 
ATOM   2183 N N     . THR B 1 46  ? -19.31300 11.38500  -20.81300 1.000 47.15872  ? 26   THR B N     1 
ATOM   2184 C CA    . THR B 1 46  ? -20.76700 11.37800  -20.78900 1.000 45.18175  ? 26   THR B CA    1 
ATOM   2185 C C     . THR B 1 46  ? -21.39000 12.69300  -21.22500 1.000 46.56684  ? 26   THR B C     1 
ATOM   2186 O O     . THR B 1 46  ? -22.58100 12.72200  -21.54700 1.000 46.29434  ? 26   THR B O     1 
ATOM   2187 C CB    . THR B 1 46  ? -21.26800 11.06600  -19.38100 1.000 50.19378  ? 26   THR B CB    1 
ATOM   2188 O OG1   . THR B 1 46  ? -20.93600 12.15900  -18.51100 1.000 46.26925  ? 26   THR B OG1   1 
ATOM   2189 C CG2   . THR B 1 46  ? -20.62300 9.77800   -18.84300 1.000 48.70700  ? 26   THR B CG2   1 
ATOM   2190 N N     . GLY B 1 47  ? -20.63500 13.78800  -21.22400 1.000 43.44484  ? 27   GLY B N     1 
ATOM   2191 C CA    . GLY B 1 47  ? -21.27000 15.06000  -21.50600 1.000 41.27355  ? 27   GLY B CA    1 
ATOM   2192 C C     . GLY B 1 47  ? -22.12600 15.55300  -20.36600 1.000 40.69611  ? 27   GLY B C     1 
ATOM   2193 O O     . GLY B 1 47  ? -23.09000 16.28700  -20.59400 1.000 42.47997  ? 27   GLY B O     1 
ATOM   2194 N N     . ARG B 1 48  ? -21.78900 15.17900  -19.13400 1.000 40.96409  ? 28   ARG B N     1 
ATOM   2195 C CA    . ARG B 1 48  ? -22.58600 15.57500  -17.98500 1.000 42.00538  ? 28   ARG B CA    1 
ATOM   2196 C C     . ARG B 1 48  ? -21.67100 16.00500  -16.85100 1.000 39.17240  ? 28   ARG B C     1 
ATOM   2197 O O     . ARG B 1 48  ? -20.52100 15.57100  -16.75500 1.000 40.42714  ? 28   ARG B O     1 
ATOM   2198 C CB    . ARG B 1 48  ? -23.52100 14.42000  -17.54800 1.000 47.22000  ? 28   ARG B CB    1 
ATOM   2199 C CG    . ARG B 1 48  ? -24.62500 14.13300  -18.58200 1.000 45.92781  ? 28   ARG B CG    1 
ATOM   2200 C CD    . ARG B 1 48  ? -25.69200 13.21300  -18.04200 1.000 52.37098  ? 28   ARG B CD    1 
ATOM   2201 N NE    . ARG B 1 48  ? -25.18900 11.86500  -17.78600 1.000 53.73945  ? 28   ARG B NE    1 
ATOM   2202 C CZ    . ARG B 1 48  ? -25.09500 10.90900  -18.71100 1.000 56.58838  ? 28   ARG B CZ    1 
ATOM   2203 N NH1   . ARG B 1 48  ? -25.46200 11.14600  -19.96700 1.000 57.80644  ? 28   ARG B NH1   1 
ATOM   2204 N NH2   . ARG B 1 48  ? -24.62800 9.70700   -18.38000 1.000 58.36907  ? 28   ARG B NH2   1 
ATOM   2205 N N     . PHE B 1 49  ? -22.18800 16.87100  -15.98800 1.000 36.22885  ? 29   PHE B N     1 
ATOM   2206 C CA    . PHE B 1 49  ? -21.41400 17.29600  -14.83000 1.000 36.91075  ? 29   PHE B CA    1 
ATOM   2207 C C     . PHE B 1 49  ? -22.37200 17.60400  -13.69100 1.000 31.66876  ? 29   PHE B C     1 
ATOM   2208 O O     . PHE B 1 49  ? -23.55900 17.86200  -13.90600 1.000 30.13956  ? 29   PHE B O     1 
ATOM   2209 C CB    . PHE B 1 49  ? -20.51700 18.50900  -15.16100 1.000 34.31298  ? 29   PHE B CB    1 
ATOM   2210 C CG    . PHE B 1 49  ? -21.26900 19.79600  -15.35800 1.000 31.82058  ? 29   PHE B CG    1 
ATOM   2211 C CD1   . PHE B 1 49  ? -22.05400 20.00200  -16.46700 1.000 34.15145  ? 29   PHE B CD1   1 
ATOM   2212 C CD2   . PHE B 1 49  ? -21.17600 20.80500  -14.42400 1.000 35.69862  ? 29   PHE B CD2   1 
ATOM   2213 C CE1   . PHE B 1 49  ? -22.76100 21.20600  -16.64000 1.000 34.24614  ? 29   PHE B CE1   1 
ATOM   2214 C CE2   . PHE B 1 49  ? -21.87300 22.02300  -14.58900 1.000 31.94104  ? 29   PHE B CE2   1 
ATOM   2215 C CZ    . PHE B 1 49  ? -22.66300 22.21900  -15.69100 1.000 29.68818  ? 29   PHE B CZ    1 
ATOM   2216 N N     . LEU B 1 50  ? -21.83200 17.58500  -12.48100 1.000 33.45981  ? 30   LEU B N     1 
ATOM   2217 C CA    . LEU B 1 50  ? -22.58600 17.81500  -11.26000 1.000 31.75058  ? 30   LEU B CA    1 
ATOM   2218 C C     . LEU B 1 50  ? -22.47900 19.26900  -10.80400 1.000 34.19444  ? 30   LEU B C     1 
ATOM   2219 O O     . LEU B 1 50  ? -21.38900 19.85200  -10.78600 1.000 33.38744  ? 30   LEU B O     1 
ATOM   2220 C CB    . LEU B 1 50  ? -22.05900 16.91100  -10.14400 1.000 32.50292  ? 30   LEU B CB    1 
ATOM   2221 C CG    . LEU B 1 50  ? -22.94400 16.66400  -8.91700  1.000 39.48140  ? 30   LEU B CG    1 
ATOM   2222 C CD1   . LEU B 1 50  ? -24.20100 15.88100  -9.30100  1.000 39.25060  ? 30   LEU B CD1   1 
ATOM   2223 C CD2   . LEU B 1 50  ? -22.18900 15.92000  -7.80900  1.000 39.89905  ? 30   LEU B CD2   1 
ATOM   2224 N N     . VAL B 1 51  ? -23.60800 19.82100  -10.37300 1.000 29.03343  ? 31   VAL B N     1 
ATOM   2225 C CA    . VAL B 1 51  ? -23.70800 21.16800  -9.82500  1.000 28.12962  ? 31   VAL B CA    1 
ATOM   2226 C C     . VAL B 1 51  ? -24.27000 21.00300  -8.42200  1.000 30.23561  ? 31   VAL B C     1 
ATOM   2227 O O     . VAL B 1 51  ? -25.43500 20.60700  -8.24900  1.000 28.99451  ? 31   VAL B O     1 
ATOM   2228 C CB    . VAL B 1 51  ? -24.60400 22.07700  -10.68000 1.000 30.51215  ? 31   VAL B CB    1 
ATOM   2229 C CG1   . VAL B 1 51  ? -24.79900 23.44000  -10.02600 1.000 26.59815  ? 31   VAL B CG1   1 
ATOM   2230 C CG2   . VAL B 1 51  ? -24.02900 22.24600  -12.10100 1.000 30.64921  ? 31   VAL B CG2   1 
ATOM   2231 N N     . GLU B 1 52  ? -23.43200 21.26400  -7.42900  1.000 29.28655  ? 32   GLU B N     1 
ATOM   2232 C CA    . GLU B 1 52  ? -23.81700 21.01300  -6.02300  1.000 31.84548  ? 32   GLU B CA    1 
ATOM   2233 C C     . GLU B 1 52  ? -24.23000 22.30100  -5.31700  1.000 34.77399  ? 32   GLU B C     1 
ATOM   2234 O O     . GLU B 1 52  ? -23.50800 23.29400  -5.40600  1.000 36.15402  ? 32   GLU B O     1 
ATOM   2235 C CB    . GLU B 1 52  ? -22.64100 20.36300  -5.29400  1.000 31.83666  ? 32   GLU B CB    1 
ATOM   2236 C CG    . GLU B 1 52  ? -22.85600 20.19600  -3.79600  1.000 33.65789  ? 32   GLU B CG    1 
ATOM   2237 C CD    . GLU B 1 52  ? -22.02800 19.10000  -3.15900  1.000 32.70506  ? 32   GLU B CD    1 
ATOM   2238 O OE1   . GLU B 1 52  ? -21.07900 18.61200  -3.79700  1.000 30.63841  ? 32   GLU B OE1   1 
ATOM   2239 O OE2   . GLU B 1 52  ? -22.34400 18.74200  -2.01300  1.000 35.65743  ? 32   GLU B OE2   1 
ATOM   2240 N N     . GLY B 1 53  ? -25.37400 22.26300  -4.65100  1.000 32.38510  ? 33   GLY B N     1 
ATOM   2241 C CA    . GLY B 1 53  ? -25.78100 23.41200  -3.85700  1.000 31.69289  ? 33   GLY B CA    1 
ATOM   2242 C C     . GLY B 1 53  ? -26.97600 24.14400  -4.42700  1.000 28.30139  ? 33   GLY B C     1 
ATOM   2243 O O     . GLY B 1 53  ? -27.00500 24.39000  -5.62300  1.000 29.48406  ? 33   GLY B O     1 
ATOM   2244 N N     . ARG B 1 54  ? -27.98300 24.48200  -3.60800  1.000 28.91055  ? 34   ARG B N     1 
ATOM   2245 C CA    . ARG B 1 54  ? -29.19700 25.09600  -4.16100  1.000 32.96260  ? 34   ARG B CA    1 
ATOM   2246 C C     . ARG B 1 54  ? -28.87100 26.34700  -4.98600  1.000 33.23071  ? 34   ARG B C     1 
ATOM   2247 O O     . ARG B 1 54  ? -29.33000 26.48600  -6.12400  1.000 29.04485  ? 34   ARG B O     1 
ATOM   2248 C CB    . ARG B 1 54  ? -30.16700 25.41800  -3.03000  1.000 31.84951  ? 34   ARG B CB    1 
ATOM   2249 C CG    . ARG B 1 54  ? -31.47700 26.02000  -3.45700  1.000 35.30072  ? 34   ARG B CG    1 
ATOM   2250 C CD    . ARG B 1 54  ? -32.32400 26.34700  -2.19800  1.000 37.56252  ? 34   ARG B CD    1 
ATOM   2251 N NE    . ARG B 1 54  ? -32.74800 25.12200  -1.53100  1.000 38.06132  ? 34   ARG B NE    1 
ATOM   2252 C CZ    . ARG B 1 54  ? -32.26500 24.66800  -0.38300  1.000 40.68220  ? 34   ARG B CZ    1 
ATOM   2253 N NH1   . ARG B 1 54  ? -31.34100 25.34000  0.29700   1.000 42.43510  ? 34   ARG B NH1   1 
ATOM   2254 N NH2   . ARG B 1 54  ? -32.73000 23.52900  0.09300   1.000 38.96892  ? 34   ARG B NH2   1 
ATOM   2255 N N     . ARG B 1 55  ? -28.01500 27.23300  -4.48100  1.000 32.26523  ? 35   ARG B N     1 
ATOM   2256 C CA    . ARG B 1 55  ? -27.75400 28.50700  -5.21000  1.000 31.91114  ? 35   ARG B CA    1 
ATOM   2257 C C     . ARG B 1 55  ? -27.12900 28.23300  -6.58700  1.000 29.25920  ? 35   ARG B C     1 
ATOM   2258 O O     . ARG B 1 55  ? -27.52900 28.86800  -7.56000  1.000 29.10249  ? 35   ARG B O     1 
ATOM   2259 C CB    . ARG B 1 55  ? -26.84900 29.45300  -4.41300  1.000 37.23354  ? 35   ARG B CB    1 
ATOM   2260 C CG    . ARG B 1 55  ? -26.48500 30.78100  -5.05800  1.000 37.87792  ? 35   ARG B CG    1 
ATOM   2261 C CD    . ARG B 1 55  ? -25.11600 31.25900  -4.59800  1.000 43.49042  ? 35   ARG B CD    1 
ATOM   2262 N NE    . ARG B 1 55  ? -25.14800 31.85200  -3.25800  1.000 47.74131  ? 35   ARG B NE    1 
ATOM   2263 C CZ    . ARG B 1 55  ? -24.26300 31.61500  -2.29700  1.000 48.95704  ? 35   ARG B CZ    1 
ATOM   2264 N NH1   . ARG B 1 55  ? -23.16300 30.93200  -2.55700  1.000 44.54573  ? 35   ARG B NH1   1 
ATOM   2265 N NH2   . ARG B 1 55  ? -24.48400 32.06400  -1.07600  1.000 43.50338  ? 35   ARG B NH2   1 
ATOM   2266 N N     . GLU B 1 56  ? -26.19600 27.29600  -6.64600  1.000 26.90606  ? 36   GLU B N     1 
ATOM   2267 C CA    . GLU B 1 56  ? -25.49200 27.01300  -7.91700  1.000 27.11342  ? 36   GLU B CA    1 
ATOM   2268 C C     . GLU B 1 56  ? -26.47000 26.34800  -8.89900  1.000 29.04470  ? 36   GLU B C     1 
ATOM   2269 O O     . GLU B 1 56  ? -26.40200 26.64800  -10.09000 1.000 30.28358  ? 36   GLU B O     1 
ATOM   2270 C CB    . GLU B 1 56  ? -24.24000 26.18800  -7.62900  1.000 27.64406  ? 36   GLU B CB    1 
ATOM   2271 C CG    . GLU B 1 56  ? -23.08300 27.01900  -7.08400  1.000 31.70091  ? 36   GLU B CG    1 
ATOM   2272 C CD    . GLU B 1 56  ? -23.27400 27.47900  -5.65200  1.000 43.03149  ? 36   GLU B CD    1 
ATOM   2273 O OE1   . GLU B 1 56  ? -22.81800 28.58700  -5.31600  1.000 42.26381  ? 36   GLU B OE1   1 
ATOM   2274 O OE2   . GLU B 1 56  ? -23.88500 26.72200  -4.87200  1.000 37.82376  ? 36   GLU B OE2   1 
ATOM   2275 N N     . VAL B 1 57  ? -27.34300 25.47600  -8.39300  1.000 32.40476  ? 37   VAL B N     1 
ATOM   2276 C CA    . VAL B 1 57  ? -28.34100 24.88000  -9.27900  1.000 27.69028  ? 37   VAL B CA    1 
ATOM   2277 C C     . VAL B 1 57  ? -29.26900 25.96300  -9.84400  1.000 24.51016  ? 37   VAL B C     1 
ATOM   2278 O O     . VAL B 1 57  ? -29.53300 26.00500  -11.05300 1.000 27.54205  ? 37   VAL B O     1 
ATOM   2279 C CB    . VAL B 1 57  ? -29.11400 23.77800  -8.52300  1.000 27.72547  ? 37   VAL B CB    1 
ATOM   2280 C CG1   . VAL B 1 57  ? -30.25500 23.29400  -9.38700  1.000 28.27111  ? 37   VAL B CG1   1 
ATOM   2281 C CG2   . VAL B 1 57  ? -28.18700 22.58900  -8.14500  1.000 29.28322  ? 37   VAL B CG2   1 
ATOM   2282 N N     . GLU B 1 58  ? -29.75200 26.87300  -8.98000  1.000 27.23149  ? 38   GLU B N     1 
ATOM   2283 C CA    . GLU B 1 58  ? -30.57400 27.99000  -9.43800  1.000 28.60127  ? 38   GLU B CA    1 
ATOM   2284 C C     . GLU B 1 58  ? -29.86400 28.75300  -10.54800 1.000 31.25156  ? 38   GLU B C     1 
ATOM   2285 O O     . GLU B 1 58  ? -30.43100 29.01600  -11.61800 1.000 26.29073  ? 38   GLU B O     1 
ATOM   2286 C CB    . GLU B 1 58  ? -30.90800 28.92700  -8.27400  1.000 26.49283  ? 38   GLU B CB    1 
ATOM   2287 C CG    . GLU B 1 58  ? -31.67200 28.23400  -7.10100  1.000 33.47517  ? 38   GLU B CG    1 
ATOM   2288 C CD    . GLU B 1 58  ? -31.78400 29.09700  -5.86400  1.000 32.98005  ? 38   GLU B CD    1 
ATOM   2289 O OE1   . GLU B 1 58  ? -32.45900 28.70000  -4.86600  1.000 35.10708  ? 38   GLU B OE1   1 
ATOM   2290 O OE2   . GLU B 1 58  ? -31.19700 30.19400  -5.87800  1.000 36.47197  ? 38   GLU B OE2   1 
ATOM   2291 N N     . ARG B 1 59  ? -28.59100 29.04300  -10.32000 1.000 29.32837  ? 39   ARG B N     1 
ATOM   2292 C CA    . ARG B 1 59  ? -27.83500 29.86200  -11.30200 1.000 29.15593  ? 39   ARG B CA    1 
ATOM   2293 C C     . ARG B 1 59  ? -27.63000 29.06700  -12.60200 1.000 28.34374  ? 39   ARG B C     1 
ATOM   2294 O O     . ARG B 1 59  ? -27.76200 29.66400  -13.67000 1.000 28.33384  ? 39   ARG B O     1 
ATOM   2295 C CB    . ARG B 1 59  ? -26.57000 30.39400  -10.61600 1.000 27.02226  ? 39   ARG B CB    1 
ATOM   2296 C CG    . ARG B 1 59  ? -26.98700 31.41700  -9.57000  1.000 35.55000  ? 39   ARG B CG    1 
ATOM   2297 C CD    . ARG B 1 59  ? -25.86200 32.18800  -8.90800  1.000 40.53957  ? 39   ARG B CD    1 
ATOM   2298 N NE    . ARG B 1 59  ? -26.36600 33.17900  -7.95000  1.000 40.77046  ? 39   ARG B NE    1 
ATOM   2299 C CZ    . ARG B 1 59  ? -25.61300 33.89200  -7.12300  1.000 43.35713  ? 39   ARG B CZ    1 
ATOM   2300 N NH1   . ARG B 1 59  ? -24.30900 33.70300  -7.08700  1.000 34.59424  ? 39   ARG B NH1   1 
ATOM   2301 N NH2   . ARG B 1 59  ? -26.16800 34.78700  -6.32800  1.000 38.09235  ? 39   ARG B NH2   1 
ATOM   2302 N N     . ALA B 1 60  ? -27.34200 27.77000  -12.49300 1.000 28.18216  ? 40   ALA B N     1 
ATOM   2303 C CA    . ALA B 1 60  ? -27.19300 26.97200  -13.71000 1.000 28.63485  ? 40   ALA B CA    1 
ATOM   2304 C C     . ALA B 1 60  ? -28.48400 26.95300  -14.50200 1.000 29.90972  ? 40   ALA B C     1 
ATOM   2305 O O     . ALA B 1 60  ? -28.46300 26.98200  -15.73700 1.000 29.33908  ? 40   ALA B O     1 
ATOM   2306 C CB    . ALA B 1 60  ? -26.78300 25.53100  -13.39200 1.000 29.48586  ? 40   ALA B CB    1 
ATOM   2307 N N     . LEU B 1 61  ? -29.61700 26.85200  -13.80900 1.000 28.84080  ? 41   LEU B N     1 
ATOM   2308 C CA    . LEU B 1 61  ? -30.88900 26.83600  -14.51900 1.000 32.62004  ? 41   LEU B CA    1 
ATOM   2309 C C     . LEU B 1 61  ? -31.14000 28.18600  -15.17100 1.000 33.71958  ? 41   LEU B C     1 
ATOM   2310 O O     . LEU B 1 61  ? -31.48600 28.26200  -16.36200 1.000 33.23982  ? 41   LEU B O     1 
ATOM   2311 C CB    . LEU B 1 61  ? -32.03700 26.47500  -13.56600 1.000 28.59088  ? 41   LEU B CB    1 
ATOM   2312 C CG    . LEU B 1 61  ? -32.09900 24.99000  -13.10900 1.000 32.94149  ? 41   LEU B CG    1 
ATOM   2313 C CD1   . LEU B 1 61  ? -32.95500 24.85600  -11.85600 1.000 28.82448  ? 41   LEU B CD1   1 
ATOM   2314 C CD2   . LEU B 1 61  ? -32.58600 24.06500  -14.23900 1.000 34.82144  ? 41   LEU B CD2   1 
ATOM   2315 N N     . GLU B 1 62  ? -30.97800 29.26700  -14.39200 1.000 31.00905  ? 42   GLU B N     1 
ATOM   2316 C CA    . GLU B 1 62  ? -31.25300 30.60500  -14.90300 1.000 32.35920  ? 42   GLU B CA    1 
ATOM   2317 C C     . GLU B 1 62  ? -30.35900 30.92900  -16.07600 1.000 34.26456  ? 42   GLU B C     1 
ATOM   2318 O O     . GLU B 1 62  ? -30.73100 31.73300  -16.93900 1.000 32.45693  ? 42   GLU B O     1 
ATOM   2319 C CB    . GLU B 1 62  ? -31.09300 31.62900  -13.78600 1.000 33.23374  ? 42   GLU B CB    1 
ATOM   2320 C CG    . GLU B 1 62  ? -32.20300 31.54500  -12.74800 1.000 34.10264  ? 42   GLU B CG    1 
ATOM   2321 C CD    . GLU B 1 62  ? -31.79700 32.01500  -11.35700 1.000 39.72364  ? 42   GLU B CD    1 
ATOM   2322 O OE1   . GLU B 1 62  ? -30.58700 32.28400  -11.12700 1.000 37.73664  ? 42   GLU B OE1   1 
ATOM   2323 O OE2   . GLU B 1 62  ? -32.70000 32.10900  -10.47300 1.000 38.87163  ? 42   GLU B OE2   1 
ATOM   2324 N N     . ALA B 1 63  ? -29.18500 30.30900  -16.13100 1.000 30.78051  ? 43   ALA B N     1 
ATOM   2325 C CA    . ALA B 1 63  ? -28.28500 30.46300  -17.25800 1.000 34.16001  ? 43   ALA B CA    1 
ATOM   2326 C C     . ALA B 1 63  ? -28.73000 29.68300  -18.47900 1.000 35.60471  ? 43   ALA B C     1 
ATOM   2327 O O     . ALA B 1 63  ? -28.12200 29.84700  -19.53300 1.000 36.17476  ? 43   ALA B O     1 
ATOM   2328 C CB    . ALA B 1 63  ? -26.87500 30.00100  -16.87900 1.000 33.28460  ? 43   ALA B CB    1 
ATOM   2329 N N     . GLY B 1 64  ? -29.74200 28.82000  -18.36500 1.000 35.06844  ? 44   GLY B N     1 
ATOM   2330 C CA    . GLY B 1 64  ? -30.22000 28.08900  -19.52600 1.000 35.12906  ? 44   GLY B CA    1 
ATOM   2331 C C     . GLY B 1 64  ? -29.61400 26.71900  -19.73600 1.000 37.22033  ? 44   GLY B C     1 
ATOM   2332 O O     . GLY B 1 64  ? -29.82800 26.12600  -20.79500 1.000 35.51909  ? 44   GLY B O     1 
ATOM   2333 N N     . LEU B 1 65  ? -28.86900 26.19100  -18.76600 1.000 32.37080  ? 45   LEU B N     1 
ATOM   2334 C CA    . LEU B 1 65  ? -28.29600 24.86900  -18.92500 1.000 35.01773  ? 45   LEU B CA    1 
ATOM   2335 C C     . LEU B 1 65  ? -29.37700 23.80200  -18.76000 1.000 34.36023  ? 45   LEU B C     1 
ATOM   2336 O O     . LEU B 1 65  ? -30.38100 24.01000  -18.07300 1.000 36.09210  ? 45   LEU B O     1 
ATOM   2337 C CB    . LEU B 1 65  ? -27.18100 24.64300  -17.91000 1.000 35.65028  ? 45   LEU B CB    1 
ATOM   2338 C CG    . LEU B 1 65  ? -25.79800 25.20600  -18.29000 1.000 36.85299  ? 45   LEU B CG    1 
ATOM   2339 C CD1   . LEU B 1 65  ? -25.75500 26.67200  -18.05700 1.000 37.54761  ? 45   LEU B CD1   1 
ATOM   2340 C CD2   . LEU B 1 65  ? -24.70500 24.52300  -17.49800 1.000 37.43761  ? 45   LEU B CD2   1 
ATOM   2341 N N     . SER B 1 66  ? -29.14300 22.63800  -19.37100 1.000 33.04678  ? 46   SER B N     1 
ATOM   2342 C CA    . SER B 1 66  ? -30.13600 21.55500  -19.41700 1.000 33.69957  ? 46   SER B CA    1 
ATOM   2343 C C     . SER B 1 66  ? -29.93600 20.63700  -18.22200 1.000 32.72771  ? 46   SER B C     1 
ATOM   2344 O O     . SER B 1 66  ? -28.90600 19.95500  -18.12000 1.000 35.03596  ? 46   SER B O     1 
ATOM   2345 C CB    . SER B 1 66  ? -30.02300 20.75000  -20.70500 1.000 36.57922  ? 46   SER B CB    1 
ATOM   2346 O OG    . SER B 1 66  ? -30.33900 21.55900  -21.82100 1.000 48.80305  ? 46   SER B OG    1 
ATOM   2347 N N     . LEU B 1 67  ? -30.91400 20.63000  -17.32500 1.000 32.03865  ? 47   LEU B N     1 
ATOM   2348 C CA    . LEU B 1 67  ? -30.91800 19.73800  -16.17300 1.000 32.69483  ? 47   LEU B CA    1 
ATOM   2349 C C     . LEU B 1 67  ? -31.40400 18.36000  -16.61200 1.000 37.19851  ? 47   LEU B C     1 
ATOM   2350 O O     . LEU B 1 67  ? -32.50700 18.23600  -17.15200 1.000 39.60653  ? 47   LEU B O     1 
ATOM   2351 C CB    . LEU B 1 67  ? -31.83700 20.29400  -15.09500 1.000 34.30905  ? 47   LEU B CB    1 
ATOM   2352 C CG    . LEU B 1 67  ? -32.02300 19.45100  -13.82100 1.000 36.19445  ? 47   LEU B CG    1 
ATOM   2353 C CD1   . LEU B 1 67  ? -30.68600 19.25300  -13.10400 1.000 31.80786  ? 47   LEU B CD1   1 
ATOM   2354 C CD2   . LEU B 1 67  ? -32.99800 20.14500  -12.91600 1.000 36.82234  ? 47   LEU B CD2   1 
ATOM   2355 N N     . GLU B 1 68  ? -30.60900 17.33100  -16.34000 1.000 37.04928  ? 48   GLU B N     1 
ATOM   2356 C CA    . GLU B 1 68  ? -30.98500 15.94900  -16.71400 1.000 38.50517  ? 48   GLU B CA    1 
ATOM   2357 C C     . GLU B 1 68  ? -31.48900 15.17500  -15.48800 1.000 42.96798  ? 48   GLU B C     1 
ATOM   2358 O O     . GLU B 1 68  ? -32.44900 14.41600  -15.63800 1.000 44.18987  ? 48   GLU B O     1 
ATOM   2359 C CB    . GLU B 1 68  ? -29.78600 15.26500  -17.35300 1.000 43.70272  ? 48   GLU B CB    1 
ATOM   2360 C CG    . GLU B 1 68  ? -29.01300 16.17000  -18.30500 1.000 44.73572  ? 48   GLU B CG    1 
ATOM   2361 C CD    . GLU B 1 68  ? -29.49500 16.06100  -19.73600 1.000 55.07250  ? 48   GLU B CD    1 
ATOM   2362 O OE1   . GLU B 1 68  ? -28.73100 15.54600  -20.57500 1.000 61.17507  ? 48   GLU B OE1   1 
ATOM   2363 O OE2   . GLU B 1 68  ? -30.63300 16.48800  -20.00900 1.000 55.69816  ? 48   GLU B OE2   1 
ATOM   2364 N N     . THR B 1 69  ? -30.84500 15.34600  -14.33600 1.000 35.75982  ? 49   THR B N     1 
ATOM   2365 C CA    . THR B 1 69  ? -31.23800 14.62100  -13.13200 1.000 33.95482  ? 49   THR B CA    1 
ATOM   2366 C C     . THR B 1 69  ? -31.10600 15.54700  -11.93800 1.000 35.46992  ? 49   THR B C     1 
ATOM   2367 O O     . THR B 1 69  ? -30.01100 16.06000  -11.67300 1.000 31.21962  ? 49   THR B O     1 
ATOM   2368 C CB    . THR B 1 69  ? -30.36400 13.37500  -12.90700 1.000 38.23293  ? 49   THR B CB    1 
ATOM   2369 O OG1   . THR B 1 69  ? -30.22600 12.65300  -14.13100 1.000 41.06940  ? 49   THR B OG1   1 
ATOM   2370 C CG2   . THR B 1 69  ? -30.98700 12.46000  -11.87300 1.000 39.70248  ? 49   THR B CG2   1 
ATOM   2371 N N     . LEU B 1 70  ? -32.18900 15.71200  -11.18900 1.000 32.64307  ? 50   LEU B N     1 
ATOM   2372 C CA    . LEU B 1 70  ? -32.16400 16.44900  -9.93200  1.000 32.58982  ? 50   LEU B CA    1 
ATOM   2373 C C     . LEU B 1 70  ? -32.01000 15.49300  -8.75300  1.000 35.00845  ? 50   LEU B C     1 
ATOM   2374 O O     . LEU B 1 70  ? -32.76800 14.52000  -8.63200  1.000 35.00786  ? 50   LEU B O     1 
ATOM   2375 C CB    . LEU B 1 70  ? -33.44600 17.27400  -9.78600  1.000 33.39994  ? 50   LEU B CB    1 
ATOM   2376 C CG    . LEU B 1 70  ? -33.55900 18.17600  -8.56500  1.000 33.75326  ? 50   LEU B CG    1 
ATOM   2377 C CD1   . LEU B 1 70  ? -32.49200 19.25900  -8.64200  1.000 36.72650  ? 50   LEU B CD1   1 
ATOM   2378 C CD2   . LEU B 1 70  ? -34.97200 18.78800  -8.49000  1.000 36.01385  ? 50   LEU B CD2   1 
ATOM   2379 N N     . LEU B 1 71  ? -31.07600 15.80000  -7.85500  1.000 30.41239  ? 51   LEU B N     1 
ATOM   2380 C CA    . LEU B 1 71  ? -30.79400 14.97500  -6.68600  1.000 33.92296  ? 51   LEU B CA    1 
ATOM   2381 C C     . LEU B 1 71  ? -31.21400 15.72700  -5.42800  1.000 32.80882  ? 51   LEU B C     1 
ATOM   2382 O O     . LEU B 1 71  ? -30.73800 16.84200  -5.18000  1.000 26.91278  ? 51   LEU B O     1 
ATOM   2383 C CB    . LEU B 1 71  ? -29.31600 14.61500  -6.60800  1.000 33.13603  ? 51   LEU B CB    1 
ATOM   2384 C CG    . LEU B 1 71  ? -28.60300 14.04200  -7.81600  1.000 32.14003  ? 51   LEU B CG    1 
ATOM   2385 C CD1   . LEU B 1 71  ? -27.14100 13.73900  -7.44200  1.000 34.23124  ? 51   LEU B CD1   1 
ATOM   2386 C CD2   . LEU B 1 71  ? -29.32900 12.77900  -8.28700  1.000 37.93241  ? 51   LEU B CD2   1 
ATOM   2387 N N     . LEU B 1 72  ? -32.07500 15.11200  -4.61600  1.000 30.30330  ? 52   LEU B N     1 
ATOM   2388 C CA    . LEU B 1 72  ? -32.58500 15.75100  -3.40300  1.000 29.01663  ? 52   LEU B CA    1 
ATOM   2389 C C     . LEU B 1 72  ? -32.23000 14.93900  -2.17300  1.000 35.22119  ? 52   LEU B C     1 
ATOM   2390 O O     . LEU B 1 72  ? -32.52300 13.74100  -2.11200  1.000 33.31945  ? 52   LEU B O     1 
ATOM   2391 C CB    . LEU B 1 72  ? -34.10400 15.93700  -3.47000  1.000 32.42174  ? 52   LEU B CB    1 
ATOM   2392 C CG    . LEU B 1 72  ? -34.61300 16.74100  -4.67800  1.000 35.66327  ? 52   LEU B CG    1 
ATOM   2393 C CD1   . LEU B 1 72  ? -36.16600 16.77500  -4.74600  1.000 36.86486  ? 52   LEU B CD1   1 
ATOM   2394 C CD2   . LEU B 1 72  ? -34.02500 18.17800  -4.69200  1.000 31.82291  ? 52   LEU B CD2   1 
ATOM   2395 N N     . GLY B 1 73  ? -31.62200 15.59800  -1.17900  1.000 29.89600  ? 53   GLY B N     1 
ATOM   2396 C CA    . GLY B 1 73  ? -31.35600 14.95400  0.08900   1.000 34.74193  ? 53   GLY B CA    1 
ATOM   2397 C C     . GLY B 1 73  ? -32.56000 14.97900  1.01800   1.000 34.88751  ? 53   GLY B C     1 
ATOM   2398 O O     . GLY B 1 73  ? -33.61700 15.54300  0.72100   1.000 33.44884  ? 53   GLY B O     1 
ATOM   2399 N N     . PRO B 1 74  ? -32.38700 14.36900  2.19100   1.000 41.80535  ? 54   PRO B N     1 
ATOM   2400 C CA    . PRO B 1 74  ? -33.51200 14.25600  3.13500   1.000 38.79381  ? 54   PRO B CA    1 
ATOM   2401 C C     . PRO B 1 74  ? -34.00200 15.58300  3.66500   1.000 39.38069  ? 54   PRO B C     1 
ATOM   2402 O O     . PRO B 1 74  ? -35.17600 15.67500  4.06400   1.000 39.33617  ? 54   PRO B O     1 
ATOM   2403 C CB    . PRO B 1 74  ? -32.93700 13.39200  4.27100   1.000 42.82805  ? 54   PRO B CB    1 
ATOM   2404 C CG    . PRO B 1 74  ? -31.76600 12.71000  3.71300   1.000 46.22361  ? 54   PRO B CG    1 
ATOM   2405 C CD    . PRO B 1 74  ? -31.20300 13.61800  2.63700   1.000 40.39433  ? 54   PRO B CD    1 
ATOM   2406 N N     . LYS B 1 75  ? -33.17200 16.62900  3.65800   1.000 37.76045  ? 55   LYS B N     1 
ATOM   2407 C CA    . LYS B 1 75  ? -33.59400 17.93800  4.13500   1.000 33.60001  ? 55   LYS B CA    1 
ATOM   2408 C C     . LYS B 1 75  ? -34.00200 18.90100  3.01800   1.000 36.25136  ? 55   LYS B C     1 
ATOM   2409 O O     . LYS B 1 75  ? -34.17800 20.09200  3.28200   1.000 37.98118  ? 55   LYS B O     1 
ATOM   2410 C CB    . LYS B 1 75  ? -32.48800 18.56000  4.98900   1.000 39.15725  ? 55   LYS B CB    1 
ATOM   2411 C CG    . LYS B 1 75  ? -32.09600 17.67700  6.16600   1.000 42.29114  ? 55   LYS B CG    1 
ATOM   2412 C CD    . LYS B 1 75  ? -31.00000 18.33800  7.01500   1.000 48.86284  ? 55   LYS B CD    1 
ATOM   2413 C CE    . LYS B 1 75  ? -30.65000 17.51200  8.24300   1.000 58.20251  ? 55   LYS B CE    1 
ATOM   2414 N NZ    . LYS B 1 75  ? -30.07000 16.17800  7.88300   1.000 65.34713  ? 55   LYS B NZ    1 
ATOM   2415 N N     . ALA B 1 76  ? -34.18900 18.42500  1.79300   1.000 35.35297  ? 56   ALA B N     1 
ATOM   2416 C CA    . ALA B 1 76  ? -34.63300 19.31000  0.72400   1.000 34.97668  ? 56   ALA B CA    1 
ATOM   2417 C C     . ALA B 1 76  ? -35.99600 19.92200  1.05800   1.000 39.44595  ? 56   ALA B C     1 
ATOM   2418 O O     . ALA B 1 76  ? -36.79100 19.34700  1.80600   1.000 41.77986  ? 56   ALA B O     1 
ATOM   2419 C CB    . ALA B 1 76  ? -34.68400 18.55100  -0.60100  1.000 33.98221  ? 56   ALA B CB    1 
ATOM   2420 N N     . ARG B 1 77  ? -36.24500 21.12400  0.52400   1.000 35.17961  ? 57   ARG B N     1 
ATOM   2421 C CA    . ARG B 1 77  ? -37.51200 21.84000  0.67200   1.000 34.84314  ? 57   ARG B CA    1 
ATOM   2422 C C     . ARG B 1 77  ? -38.52500 21.39100  -0.38400  1.000 38.59384  ? 57   ARG B C     1 
ATOM   2423 O O     . ARG B 1 77  ? -38.14000 20.96000  -1.46900  1.000 36.87431  ? 57   ARG B O     1 
ATOM   2424 C CB    . ARG B 1 77  ? -37.31100 23.34400  0.47300   1.000 41.32796  ? 57   ARG B CB    1 
ATOM   2425 C CG    . ARG B 1 77  ? -36.10300 24.02300  1.07700   1.000 42.39733  ? 57   ARG B CG    1 
ATOM   2426 C CD    . ARG B 1 77  ? -35.98900 25.39900  0.39500   1.000 44.39102  ? 57   ARG B CD    1 
ATOM   2427 N NE    . ARG B 1 77  ? -35.25700 26.37100  1.19700   1.000 49.81541  ? 57   ARG B NE    1 
ATOM   2428 C CZ    . ARG B 1 77  ? -35.04500 27.62900  0.81900   1.000 48.39195  ? 57   ARG B CZ    1 
ATOM   2429 N NH1   . ARG B 1 77  ? -35.48800 28.06400  -0.36800  1.000 42.52925  ? 57   ARG B NH1   1 
ATOM   2430 N NH2   . ARG B 1 77  ? -34.37600 28.44800  1.62700   1.000 56.58363  ? 57   ARG B NH2   1 
ATOM   2431 N N     . PRO B 1 78  ? -39.83400 21.58500  -0.13700  1.000 34.90239  ? 58   PRO B N     1 
ATOM   2432 C CA    . PRO B 1 78  ? -40.81700 21.26400  -1.19200  1.000 36.87678  ? 58   PRO B CA    1 
ATOM   2433 C C     . PRO B 1 78  ? -40.53200 21.97400  -2.50200  1.000 35.60187  ? 58   PRO B C     1 
ATOM   2434 O O     . PRO B 1 78  ? -40.69100 21.37200  -3.56800  1.000 34.80873  ? 58   PRO B O     1 
ATOM   2435 C CB    . PRO B 1 78  ? -42.15700 21.72300  -0.57800  1.000 42.59901  ? 58   PRO B CB    1 
ATOM   2436 C CG    . PRO B 1 78  ? -41.92700 21.64800  0.90800   1.000 41.78098  ? 58   PRO B CG    1 
ATOM   2437 C CD    . PRO B 1 78  ? -40.48100 22.02400  1.11100   1.000 38.40103  ? 58   PRO B CD    1 
ATOM   2438 N N     . GLU B 1 79  ? -40.08800 23.24100  -2.45200  1.000 38.22618  ? 59   GLU B N     1 
ATOM   2439 C CA    . GLU B 1 79  ? -39.85200 23.98200  -3.68900  1.000 36.24234  ? 59   GLU B CA    1 
ATOM   2440 C C     . GLU B 1 79  ? -38.73400 23.35900  -4.51800  1.000 32.65800  ? 59   GLU B C     1 
ATOM   2441 O O     . GLU B 1 79  ? -38.75700 23.45900  -5.74800  1.000 38.12632  ? 59   GLU B O     1 
ATOM   2442 C CB    . GLU B 1 79  ? -39.57500 25.47000  -3.39000  1.000 31.89389  ? 59   GLU B CB    1 
ATOM   2443 C CG    . GLU B 1 79  ? -39.59400 26.33400  -4.66600  1.000 33.88137  ? 59   GLU B CG    1 
ATOM   2444 C CD    . GLU B 1 79  ? -39.42200 27.82700  -4.42000  1.000 38.46738  ? 59   GLU B CD    1 
ATOM   2445 O OE1   . GLU B 1 79  ? -39.17300 28.23100  -3.26700  1.000 40.16692  ? 59   GLU B OE1   1 
ATOM   2446 O OE2   . GLU B 1 79  ? -39.57100 28.60000  -5.39400  1.000 38.08816  ? 59   GLU B OE2   1 
ATOM   2447 N N     . ASP B 1 80  ? -37.78200 22.67200  -3.88100  1.000 31.98333  ? 60   ASP B N     1 
ATOM   2448 C CA    . ASP B 1 80  ? -36.64600 22.09800  -4.61500  1.000 34.85625  ? 60   ASP B CA    1 
ATOM   2449 C C     . ASP B 1 80  ? -37.09700 21.11800  -5.68900  1.000 32.36460  ? 60   ASP B C     1 
ATOM   2450 O O     . ASP B 1 80  ? -36.58300 21.11900  -6.81200  1.000 34.43750  ? 60   ASP B O     1 
ATOM   2451 C CB    . ASP B 1 80  ? -35.68000 21.39700  -3.65200  1.000 33.33146  ? 60   ASP B CB    1 
ATOM   2452 C CG    . ASP B 1 80  ? -35.02800 22.35200  -2.67400  1.000 34.64273  ? 60   ASP B CG    1 
ATOM   2453 O OD1   . ASP B 1 80  ? -34.90700 23.56600  -3.00100  1.000 33.36936  ? 60   ASP B OD1   1 
ATOM   2454 O OD2   . ASP B 1 80  ? -34.62400 21.89300  -1.58200  1.000 34.28844  ? 60   ASP B OD2   1 
ATOM   2455 N N     . ARG B 1 81  ? -38.02900 20.23900  -5.36000  1.000 34.39022  ? 61   ARG B N     1 
ATOM   2456 C CA    . ARG B 1 81  ? -38.51800 19.32200  -6.38300  1.000 32.99242  ? 61   ARG B CA    1 
ATOM   2457 C C     . ARG B 1 81  ? -39.10400 20.07200  -7.57700  1.000 31.76247  ? 61   ARG B C     1 
ATOM   2458 O O     . ARG B 1 81  ? -38.97100 19.61900  -8.71700  1.000 34.18669  ? 61   ARG B O     1 
ATOM   2459 C CB    . ARG B 1 81  ? -39.54700 18.37200  -5.74700  1.000 39.57136  ? 61   ARG B CB    1 
ATOM   2460 C CG    . ARG B 1 81  ? -40.25400 17.47300  -6.69600  1.000 38.24570  ? 61   ARG B CG    1 
ATOM   2461 C CD    . ARG B 1 81  ? -41.27000 16.57100  -5.93400  1.000 45.82531  ? 61   ARG B CD    1 
ATOM   2462 N NE    . ARG B 1 81  ? -40.60000 15.43400  -5.31700  1.000 43.26287  ? 61   ARG B NE    1 
ATOM   2463 C CZ    . ARG B 1 81  ? -40.19000 14.37700  -6.00900  1.000 40.94012  ? 61   ARG B CZ    1 
ATOM   2464 N NH1   . ARG B 1 81  ? -40.40100 14.32700  -7.32000  1.000 35.08480  ? 61   ARG B NH1   1 
ATOM   2465 N NH2   . ARG B 1 81  ? -39.57100 13.37300  -5.39500  1.000 46.84566  ? 61   ARG B NH2   1 
ATOM   2466 N N     . ALA B 1 82  ? -39.71600 21.24400  -7.34900  1.000 31.88042  ? 62   ALA B N     1 
ATOM   2467 C CA    . ALA B 1 82  ? -40.31800 21.98800  -8.45200  1.000 34.67072  ? 62   ALA B CA    1 
ATOM   2468 C C     . ALA B 1 82  ? -39.29100 22.52700  -9.43400  1.000 36.20182  ? 62   ALA B C     1 
ATOM   2469 O O     . ALA B 1 82  ? -39.68200 22.98400  -10.51000 1.000 32.15455  ? 62   ALA B O     1 
ATOM   2470 C CB    . ALA B 1 82  ? -41.14900 23.15900  -7.94200  1.000 33.82483  ? 62   ALA B CB    1 
ATOM   2471 N N     . LEU B 1 83  ? -37.99500 22.48200  -9.09400  1.000 34.75799  ? 63   LEU B N     1 
ATOM   2472 C CA    . LEU B 1 83  ? -36.94300 22.93100  -10.01400 1.000 33.63510  ? 63   LEU B CA    1 
ATOM   2473 C C     . LEU B 1 83  ? -36.70900 21.99300  -11.20000 1.000 38.43350  ? 63   LEU B C     1 
ATOM   2474 O O     . LEU B 1 83  ? -36.07300 22.41800  -12.16400 1.000 31.36278  ? 63   LEU B O     1 
ATOM   2475 C CB    . LEU B 1 83  ? -35.61300 23.10600  -9.25300  1.000 28.26950  ? 63   LEU B CB    1 
ATOM   2476 C CG    . LEU B 1 83  ? -35.57200 24.21200  -8.20400  1.000 30.08590  ? 63   LEU B CG    1 
ATOM   2477 C CD1   . LEU B 1 83  ? -34.28100 24.17400  -7.35900  1.000 31.39982  ? 63   LEU B CD1   1 
ATOM   2478 C CD2   . LEU B 1 83  ? -35.65000 25.56200  -8.88000  1.000 33.52252  ? 63   LEU B CD2   1 
ATOM   2479 N N     . ALA B 1 84  ? -37.23400 20.75600  -11.18200 1.000 35.98121  ? 64   ALA B N     1 
ATOM   2480 C CA    . ALA B 1 84  ? -36.78500 19.71700  -12.11400 1.000 34.58370  ? 64   ALA B CA    1 
ATOM   2481 C C     . ALA B 1 84  ? -37.15700 19.99400  -13.57000 1.000 40.97563  ? 64   ALA B C     1 
ATOM   2482 O O     . ALA B 1 84  ? -36.40900 19.61600  -14.48500 1.000 42.75937  ? 64   ALA B O     1 
ATOM   2483 C CB    . ALA B 1 84  ? -37.35500 18.35300  -11.70000 1.000 39.71952  ? 64   ALA B CB    1 
ATOM   2484 N N     . GLY B 1 85  ? -38.30100 20.60700  -13.82100 1.000 40.95425  ? 65   GLY B N     1 
ATOM   2485 C CA    . GLY B 1 85  ? -38.63700 20.94200  -15.19700 1.000 44.83456  ? 65   GLY B CA    1 
ATOM   2486 C C     . GLY B 1 85  ? -38.76000 19.74700  -16.12000 1.000 49.93417  ? 65   GLY B C     1 
ATOM   2487 O O     . GLY B 1 85  ? -38.39200 19.84200  -17.29900 1.000 51.73588  ? 65   GLY B O     1 
ATOM   2488 N N     . GLY B 1 86  ? -39.24600 18.61100  -15.61700 1.000 44.18351  ? 66   GLY B N     1 
ATOM   2489 C CA    . GLY B 1 86  ? -39.30100 17.41500  -16.44000 1.000 47.17377  ? 66   GLY B CA    1 
ATOM   2490 C C     . GLY B 1 86  ? -38.07300 16.51700  -16.38900 1.000 51.17067  ? 66   GLY B C     1 
ATOM   2491 O O     . GLY B 1 86  ? -38.04600 15.48200  -17.07400 1.000 47.79659  ? 66   GLY B O     1 
ATOM   2492 N N     . ALA B 1 87  ? -37.04800 16.87300  -15.62500 1.000 45.85906  ? 67   ALA B N     1 
ATOM   2493 C CA    . ALA B 1 87  ? -35.95200 15.93600  -15.47100 1.000 45.28943  ? 67   ALA B CA    1 
ATOM   2494 C C     . ALA B 1 87  ? -36.31000 14.88400  -14.42400 1.000 40.41678  ? 67   ALA B C     1 
ATOM   2495 O O     . ALA B 1 87  ? -37.18500 15.08000  -13.58000 1.000 42.04555  ? 67   ALA B O     1 
ATOM   2496 C CB    . ALA B 1 87  ? -34.65400 16.66200  -15.07700 1.000 42.40583  ? 67   ALA B CB    1 
ATOM   2497 N N     . GLU B 1 88  ? -35.61800 13.75200  -14.50700 1.000 43.71127  ? 68   GLU B N     1 
ATOM   2498 C CA    . GLU B 1 88  ? -35.70200 12.73300  -13.47300 1.000 41.01667  ? 68   GLU B CA    1 
ATOM   2499 C C     . GLU B 1 88  ? -35.27600 13.31200  -12.12500 1.000 41.65338  ? 68   GLU B C     1 
ATOM   2500 O O     . GLU B 1 88  ? -34.24900 14.00100  -12.02700 1.000 40.10870  ? 68   GLU B O     1 
ATOM   2501 C CB    . GLU B 1 88  ? -34.82000 11.54900  -13.86100 1.000 43.17148  ? 68   GLU B CB    1 
ATOM   2502 C CG    . GLU B 1 88  ? -34.69400 10.50800  -12.77300 1.000 46.16045  ? 68   GLU B CG    1 
ATOM   2503 C CD    . GLU B 1 88  ? -33.90000 9.31200   -13.22600 1.000 49.93516  ? 68   GLU B CD    1 
ATOM   2504 O OE1   . GLU B 1 88  ? -32.95000 9.50100   -14.00300 1.000 54.16530  ? 68   GLU B OE1   1 
ATOM   2505 O OE2   . GLU B 1 88  ? -34.23800 8.18400   -12.82300 1.000 55.15569  ? 68   GLU B OE2   1 
ATOM   2506 N N     . VAL B 1 89  ? -36.08700 13.06700  -11.09700 1.000 37.05812  ? 69   VAL B N     1 
ATOM   2507 C CA    . VAL B 1 89  ? -35.80300 13.45400  -9.71000  1.000 33.57575  ? 69   VAL B CA    1 
ATOM   2508 C C     . VAL B 1 89  ? -35.46400 12.20200  -8.90000  1.000 40.34190  ? 69   VAL B C     1 
ATOM   2509 O O     . VAL B 1 89  ? -36.27800 11.27600  -8.83400  1.000 37.42474  ? 69   VAL B O     1 
ATOM   2510 C CB    . VAL B 1 89  ? -37.00600 14.16900  -9.09700  1.000 31.18602  ? 69   VAL B CB    1 
ATOM   2511 C CG1   . VAL B 1 89  ? -36.74400 14.48900  -7.65000  1.000 31.54982  ? 69   VAL B CG1   1 
ATOM   2512 C CG2   . VAL B 1 89  ? -37.36000 15.39600  -9.90600  1.000 34.60936  ? 69   VAL B CG2   1 
ATOM   2513 N N     . LEU B 1 90  ? -34.28000 12.17400  -8.27000  1.000 34.84942  ? 70   LEU B N     1 
ATOM   2514 C CA    . LEU B 1 90  ? -33.85100 11.09000  -7.39500  1.000 34.87837  ? 70   LEU B CA    1 
ATOM   2515 C C     . LEU B 1 90  ? -33.78100 11.58800  -5.95600  1.000 39.00802  ? 70   LEU B C     1 
ATOM   2516 O O     . LEU B 1 90  ? -33.19900 12.64700  -5.68000  1.000 38.25877  ? 70   LEU B O     1 
ATOM   2517 C CB    . LEU B 1 90  ? -32.48100 10.54500  -7.80900  1.000 36.89754  ? 70   LEU B CB    1 
ATOM   2518 C CG    . LEU B 1 90  ? -32.42600 9.98100   -9.21500  1.000 42.22527  ? 70   LEU B CG    1 
ATOM   2519 C CD1   . LEU B 1 90  ? -31.02900 9.59500   -9.56400  1.000 37.26780  ? 70   LEU B CD1   1 
ATOM   2520 C CD2   . LEU B 1 90  ? -33.36100 8.77700   -9.31300  1.000 45.64343  ? 70   LEU B CD2   1 
ATOM   2521 N N     . GLU B 1 91  ? -34.36400 10.83000  -5.04100  1.000 32.46971  ? 71   GLU B N     1 
ATOM   2522 C CA    . GLU B 1 91  ? -34.27300 11.10500  -3.61300  1.000 38.27384  ? 71   GLU B CA    1 
ATOM   2523 C C     . GLU B 1 91  ? -33.17500 10.21600  -3.04900  1.000 40.48492  ? 71   GLU B C     1 
ATOM   2524 O O     . GLU B 1 91  ? -33.25600 8.99100   -3.15400  1.000 39.51003  ? 71   GLU B O     1 
ATOM   2525 C CB    . GLU B 1 91  ? -35.60500 10.83300  -2.90900  1.000 41.97605  ? 71   GLU B CB    1 
ATOM   2526 C CG    . GLU B 1 91  ? -36.76700 11.68400  -3.36600  1.000 40.84268  ? 71   GLU B CG    1 
ATOM   2527 C CD    . GLU B 1 91  ? -36.87400 13.00300  -2.61600  1.000 46.93617  ? 71   GLU B CD    1 
ATOM   2528 O OE1   . GLU B 1 91  ? -36.13300 13.22300  -1.61100  1.000 46.97701  ? 71   GLU B OE1   1 
ATOM   2529 O OE2   . GLU B 1 91  ? -37.69900 13.84600  -3.04700  1.000 49.26967  ? 71   GLU B OE2   1 
ATOM   2530 N N     . LEU B 1 92  ? -32.13300 10.81900  -2.49300  1.000 39.58648  ? 72   LEU B N     1 
ATOM   2531 C CA    . LEU B 1 92  ? -31.02000 10.05700  -1.95200  1.000 37.16826  ? 72   LEU B CA    1 
ATOM   2532 C C     . LEU B 1 92  ? -30.99400 10.21300  -0.44600  1.000 37.28639  ? 72   LEU B C     1 
ATOM   2533 O O     . LEU B 1 92  ? -31.47800 11.20600  0.09400   1.000 41.10896  ? 72   LEU B O     1 
ATOM   2534 C CB    . LEU B 1 92  ? -29.67700 10.53000  -2.51100  1.000 40.06290  ? 72   LEU B CB    1 
ATOM   2535 C CG    . LEU B 1 92  ? -29.42900 10.79100  -3.99100  1.000 43.16277  ? 72   LEU B CG    1 
ATOM   2536 C CD1   . LEU B 1 92  ? -27.92600 11.06000  -4.21400  1.000 43.11324  ? 72   LEU B CD1   1 
ATOM   2537 C CD2   . LEU B 1 92  ? -29.89100 9.67900   -4.89800  1.000 38.92473  ? 72   LEU B CD2   1 
ATOM   2538 N N     . SER B 1 93  ? -30.42900 9.22500   0.23400   1.000 38.57569  ? 73   SER B N     1 
ATOM   2539 C CA    . SER B 1 93  ? -30.17700 9.35900   1.66000   1.000 39.57532  ? 73   SER B CA    1 
ATOM   2540 C C     . SER B 1 93  ? -28.91600 10.17700  1.90300   1.000 43.16484  ? 73   SER B C     1 
ATOM   2541 O O     . SER B 1 93  ? -28.13700 10.45100  0.98400   1.000 42.34582  ? 73   SER B O     1 
ATOM   2542 C CB    . SER B 1 93  ? -29.98900 7.99100   2.28900   1.000 44.87753  ? 73   SER B CB    1 
ATOM   2543 O OG    . SER B 1 93  ? -29.09700 7.26900   1.47500   1.000 40.41566  ? 73   SER B OG    1 
ATOM   2544 N N     . GLU B 1 94  ? -28.68000 10.52300  3.17800   1.000 45.66498  ? 74   GLU B N     1 
ATOM   2545 C CA    . GLU B 1 94  ? -27.43300 11.20700  3.51300   1.000 46.24348  ? 74   GLU B CA    1 
ATOM   2546 C C     . GLU B 1 94  ? -26.24300 10.38300  3.07300   1.000 41.29470  ? 74   GLU B C     1 
ATOM   2547 O O     . GLU B 1 94  ? -25.28600 10.91500  2.51000   1.000 41.50774  ? 74   GLU B O     1 
ATOM   2548 C CB    . GLU B 1 94  ? -27.33700 11.49700  5.01200   1.000 46.79180  ? 74   GLU B CB    1 
ATOM   2549 C CG    . GLU B 1 94  ? -28.27500 12.57600  5.50200   1.000 48.74033  ? 74   GLU B CG    1 
ATOM   2550 C CD    . GLU B 1 94  ? -27.91000 14.00200  5.03200   1.000 53.73249  ? 74   GLU B CD    1 
ATOM   2551 O OE1   . GLU B 1 94  ? -26.88900 14.19900  4.31600   1.000 50.09699  ? 74   GLU B OE1   1 
ATOM   2552 O OE2   . GLU B 1 94  ? -28.66700 14.93400  5.40000   1.000 54.51385  ? 74   GLU B OE2   1 
ATOM   2553 N N     . ARG B 1 95  ? -26.32000 9.07300   3.25600   1.000 43.13048  ? 75   ARG B N     1 
ATOM   2554 C CA    . ARG B 1 95  ? -25.15000 8.21500   2.93700   1.000 43.46825  ? 75   ARG B CA    1 
ATOM   2555 C C     . ARG B 1 95  ? -24.93400 8.15700   1.42100   1.000 42.94055  ? 75   ARG B C     1 
ATOM   2556 O O     . ARG B 1 95  ? -23.78000 8.18500   0.99100   1.000 41.48590  ? 75   ARG B O     1 
ATOM   2557 C CB    . ARG B 1 95  ? -25.31900 6.83400   3.57800   1.000 51.33401  ? 75   ARG B CB    1 
ATOM   2558 C CG    . ARG B 1 95  ? -24.94600 6.87800   5.05200   1.000 57.82762  ? 75   ARG B CG    1 
ATOM   2559 C CD    . ARG B 1 95  ? -24.99200 5.53700   5.76800   1.000 64.66147  ? 75   ARG B CD    1 
ATOM   2560 N NE    . ARG B 1 95  ? -24.24300 4.47900   5.08200   1.000 65.45795  ? 75   ARG B NE    1 
ATOM   2561 C CZ    . ARG B 1 95  ? -22.92900 4.31200   5.15100   1.000 69.56051  ? 75   ARG B CZ    1 
ATOM   2562 N NH1   . ARG B 1 95  ? -22.21000 5.04300   5.98300   1.000 63.59335  ? 75   ARG B NH1   1 
ATOM   2563 N NH2   . ARG B 1 95  ? -22.33900 3.41000   4.38700   1.000 65.76621  ? 75   ARG B NH2   1 
ATOM   2564 N N     . ALA B 1 96  ? -26.01100 8.03600   0.65400   1.000 40.86336  ? 76   ALA B N     1 
ATOM   2565 C CA    . ALA B 1 96  ? -25.84000 8.09200   -0.79300  1.000 42.03485  ? 76   ALA B CA    1 
ATOM   2566 C C     . ALA B 1 96  ? -25.39000 9.48400   -1.22800  1.000 41.91402  ? 76   ALA B C     1 
ATOM   2567 O O     . ALA B 1 96  ? -24.49600 9.62700   -2.07100  1.000 40.46693  ? 76   ALA B O     1 
ATOM   2568 C CB    . ALA B 1 96  ? -27.14100 7.69700   -1.50200  1.000 38.84642  ? 76   ALA B CB    1 
ATOM   2569 N N     . LEU B 1 97  ? -25.98300 10.52300  -0.64100  1.000 39.09821  ? 77   LEU B N     1 
ATOM   2570 C CA    . LEU B 1 97  ? -25.54500 11.88500  -0.94300  1.000 41.25941  ? 77   LEU B CA    1 
ATOM   2571 C C     . LEU B 1 97  ? -24.04000 12.06100  -0.72500  1.000 42.47991  ? 77   LEU B C     1 
ATOM   2572 O O     . LEU B 1 97  ? -23.35000 12.67600  -1.55300  1.000 40.87322  ? 77   LEU B O     1 
ATOM   2573 C CB    . LEU B 1 97  ? -26.33800 12.86000  -0.08600  1.000 41.53116  ? 77   LEU B CB    1 
ATOM   2574 C CG    . LEU B 1 97  ? -26.62000 14.21200  -0.68500  1.000 42.22983  ? 77   LEU B CG    1 
ATOM   2575 C CD1   . LEU B 1 97  ? -27.32700 14.03500  -2.01500  1.000 40.97762  ? 77   LEU B CD1   1 
ATOM   2576 C CD2   . LEU B 1 97  ? -27.49300 14.89900  0.30900   1.000 44.89589  ? 77   LEU B CD2   1 
ATOM   2577 N N     . ALA B 1 98  ? -23.49500 11.45600  0.34400   1.000 44.35717  ? 78   ALA B N     1 
ATOM   2578 C CA    . ALA B 1 98  ? -22.09800 11.69800  0.72000   1.000 36.14130  ? 78   ALA B CA    1 
ATOM   2579 C C     . ALA B 1 98  ? -21.12100 11.17600  -0.32100  1.000 41.82350  ? 78   ALA B C     1 
ATOM   2580 O O     . ALA B 1 98  ? -19.99000 11.67900  -0.42500  1.000 41.15892  ? 78   ALA B O     1 
ATOM   2581 C CB    . ALA B 1 98  ? -21.78600 11.05500  2.07500   1.000 43.42683  ? 78   ALA B CB    1 
ATOM   2582 N N     . ARG B 1 99  ? -21.53200 10.17300  -1.08800  1.000 37.09493  ? 79   ARG B N     1 
ATOM   2583 C CA    . ARG B 1 99  ? -20.67000 9.55800   -2.08600  1.000 41.75406  ? 79   ARG B CA    1 
ATOM   2584 C C     . ARG B 1 99  ? -20.60500 10.40700  -3.35500  1.000 43.64464  ? 79   ARG B C     1 
ATOM   2585 O O     . ARG B 1 99  ? -19.60800 10.36400  -4.08800  1.000 43.36615  ? 79   ARG B O     1 
ATOM   2586 C CB    . ARG B 1 99  ? -21.19400 8.14600   -2.38000  1.000 42.36304  ? 79   ARG B CB    1 
ATOM   2587 C CG    . ARG B 1 99  ? -20.56600 7.45400   -3.56000  1.000 50.38230  ? 79   ARG B CG    1 
ATOM   2588 C CD    . ARG B 1 99  ? -19.50900 6.42800   -3.16100  1.000 56.35789  ? 79   ARG B CD    1 
ATOM   2589 N NE    . ARG B 1 99  ? -18.94300 5.83900   -4.37300  1.000 58.00281  ? 79   ARG B NE    1 
ATOM   2590 C CZ    . ARG B 1 99  ? -19.33900 4.68100   -4.89700  1.000 62.41524  ? 79   ARG B CZ    1 
ATOM   2591 N NH1   . ARG B 1 99  ? -20.28600 3.96200   -4.29200  1.000 59.40757  ? 79   ARG B NH1   1 
ATOM   2592 N NH2   . ARG B 1 99  ? -18.78000 4.23000   -6.01900  1.000 63.10155  ? 79   ARG B NH2   1 
ATOM   2593 N N     . VAL B 1 100 ? -21.63900 11.20300  -3.60200  1.000 41.78538  ? 80   VAL B N     1 
ATOM   2594 C CA    . VAL B 1 100 ? -21.71300 12.03500  -4.80500  1.000 43.49331  ? 80   VAL B CA    1 
ATOM   2595 C C     . VAL B 1 100 ? -21.13000 13.43100  -4.57300  1.000 38.65977  ? 80   VAL B C     1 
ATOM   2596 O O     . VAL B 1 100 ? -20.52600 14.00500  -5.47600  1.000 38.38035  ? 80   VAL B O     1 
ATOM   2597 C CB    . VAL B 1 100 ? -23.18200 12.09800  -5.26100  1.000 40.61639  ? 80   VAL B CB    1 
ATOM   2598 C CG1   . VAL B 1 100 ? -23.29600 12.86600  -6.49800  1.000 42.81138  ? 80   VAL B CG1   1 
ATOM   2599 C CG2   . VAL B 1 100 ? -23.72800 10.66300  -5.48200  1.000 37.57522  ? 80   VAL B CG2   1 
ATOM   2600 N N     . SER B 1 101 ? -21.29700 13.95900  -3.35900  1.000 40.22662  ? 81   SER B N     1 
ATOM   2601 C CA    . SER B 1 101 ? -20.91400 15.31200  -2.98200  1.000 36.06021  ? 81   SER B CA    1 
ATOM   2602 C C     . SER B 1 101 ? -19.40000 15.52800  -3.05200  1.000 42.44163  ? 81   SER B C     1 
ATOM   2603 O O     . SER B 1 101 ? -18.60200 14.60400  -2.90300  1.000 39.35744  ? 81   SER B O     1 
ATOM   2604 C CB    . SER B 1 101 ? -21.39800 15.58600  -1.56500  1.000 36.72455  ? 81   SER B CB    1 
ATOM   2605 O OG    . SER B 1 101 ? -20.98800 16.83700  -1.04400  1.000 38.67834  ? 81   SER B OG    1 
ATOM   2606 N N     . ALA B 1 102 ? -18.99600 16.78500  -3.18100  1.000 43.34374  ? 82   ALA B N     1 
ATOM   2607 C CA    . ALA B 1 102 ? -17.55800 17.11400  -3.12300  1.000 46.97953  ? 82   ALA B CA    1 
ATOM   2608 C C     . ALA B 1 102 ? -17.27100 17.66300  -1.73700  1.000 44.84160  ? 82   ALA B C     1 
ATOM   2609 O O     . ALA B 1 102 ? -16.15000 18.13700  -1.50700  1.000 49.83310  ? 82   ALA B O     1 
ATOM   2610 C CB    . ALA B 1 102 ? -17.27600 18.18000  -4.12200  1.000 48.95790  ? 82   ALA B CB    1 
ATOM   2611 N N     . ARG B 1 103 ? -18.26600 17.61800  -0.86100  1.000 41.01285  ? 83   ARG B N     1 
ATOM   2612 C CA    . ARG B 1 103 ? -18.12300 18.26400  0.45800   1.000 40.27207  ? 83   ARG B CA    1 
ATOM   2613 C C     . ARG B 1 103 ? -18.13400 17.27300  1.62300   1.000 43.16268  ? 83   ARG B C     1 
ATOM   2614 O O     . ARG B 1 103 ? -18.80300 16.23100  1.51700   1.000 39.58373  ? 83   ARG B O     1 
ATOM   2615 C CB    . ARG B 1 103 ? -19.34400 19.15800  0.66900   1.000 37.17411  ? 83   ARG B CB    1 
ATOM   2616 C CG    . ARG B 1 103 ? -19.39900 20.55900  0.08800   1.000 36.60086  ? 83   ARG B CG    1 
ATOM   2617 C CD    . ARG B 1 103 ? -20.69000 21.24600  0.49800   1.000 35.69527  ? 83   ARG B CD    1 
ATOM   2618 N NE    . ARG B 1 103 ? -21.33000 21.94900  -0.61700  1.000 35.33296  ? 83   ARG B NE    1 
ATOM   2619 C CZ    . ARG B 1 103 ? -22.41400 22.69900  -0.51600  1.000 38.88175  ? 83   ARG B CZ    1 
ATOM   2620 N NH1   . ARG B 1 103 ? -23.17600 22.62400  0.55700   1.000 40.25812  ? 83   ARG B NH1   1 
ATOM   2621 N NH2   . ARG B 1 103 ? -22.73900 23.52100  -1.49300  1.000 43.88362  ? 83   ARG B NH2   1 
ATOM   2622 N N     . GLU B 1 104 ? -17.43600 17.62400  2.69800   1.000 37.80566  ? 84   GLU B N     1 
ATOM   2623 C CA    . GLU B 1 104 ? -17.50100 16.81400  3.92800   1.000 43.34272  ? 84   GLU B CA    1 
ATOM   2624 C C     . GLU B 1 104 ? -18.94800 16.85200  4.42400   1.000 40.21711  ? 84   GLU B C     1 
ATOM   2625 O O     . GLU B 1 104 ? -19.40400 15.83300  4.94700   1.000 42.61074  ? 84   GLU B O     1 
ATOM   2626 C CB    . GLU B 1 104 ? -16.61300 17.46900  4.98000   1.000 41.70148  ? 84   GLU B CB    1 
ATOM   2627 C CG    . GLU B 1 104 ? -15.11400 17.31300  4.75800   1.000 47.41619  ? 84   GLU B CG    1 
ATOM   2628 C CD    . GLU B 1 104 ? -14.34000 18.18500  5.73300   1.000 53.09833  ? 84   GLU B CD    1 
ATOM   2629 O OE1   . GLU B 1 104 ? -14.93300 18.58800  6.75400   1.000 48.25854  ? 84   GLU B OE1   1 
ATOM   2630 O OE2   . GLU B 1 104 ? -13.15700 18.47200  5.47300   1.000 56.11561  ? 84   GLU B OE2   1 
ATOM   2631 N N     . ASN B 1 105 ? -19.60800 18.00900  4.31900   1.000 35.96039  ? 85   ASN B N     1 
ATOM   2632 C CA    . ASN B 1 105 ? -21.03400 18.14700  4.71900   1.000 36.27138  ? 85   ASN B CA    1 
ATOM   2633 C C     . ASN B 1 105 ? -21.84000 18.47700  3.46700   1.000 40.38782  ? 85   ASN B C     1 
ATOM   2634 O O     . ASN B 1 105 ? -21.96000 19.66100  3.13300   1.000 36.58752  ? 85   ASN B O     1 
ATOM   2635 C CB    . ASN B 1 105 ? -21.23500 19.19400  5.80100   1.000 39.08667  ? 85   ASN B CB    1 
ATOM   2636 C CG    . ASN B 1 105 ? -20.92000 18.65100  7.17400   1.000 49.77155  ? 85   ASN B CG    1 
ATOM   2637 O OD1   . ASN B 1 105 ? -21.05400 17.44500  7.40700   1.000 47.14090  ? 85   ASN B OD1   1 
ATOM   2638 N ND2   . ASN B 1 105 ? -20.50800 19.51500  8.08900   1.000 42.77701  ? 85   ASN B ND2   1 
ATOM   2639 N N     . PRO B 1 106 ? -22.44200 17.48400  2.80000   1.000 32.98159  ? 86   PRO B N     1 
ATOM   2640 C CA    . PRO B 1 106 ? -23.08800 17.73300  1.52200   1.000 34.72019  ? 86   PRO B CA    1 
ATOM   2641 C C     . PRO B 1 106 ? -24.27600 18.65700  1.40000   1.000 36.45680  ? 86   PRO B C     1 
ATOM   2642 O O     . PRO B 1 106 ? -24.98300 18.88900  2.38500   1.000 32.69035  ? 86   PRO B O     1 
ATOM   2643 C CB    . PRO B 1 106 ? -23.47700 16.29900  1.10200   1.000 37.95799  ? 86   PRO B CB    1 
ATOM   2644 C CG    . PRO B 1 106 ? -22.56800 15.40800  1.90700   1.000 39.58011  ? 86   PRO B CG    1 
ATOM   2645 C CD    . PRO B 1 106 ? -22.50000 16.11100  3.24000   1.000 40.80669  ? 86   PRO B CD    1 
ATOM   2646 N N     . ALA B 1 107 ? -24.42900 19.24700  0.21300   1.000 33.84274  ? 87   ALA B N     1 
ATOM   2647 C CA    . ALA B 1 107 ? -25.61600 20.01400  -0.09300  1.000 36.18019  ? 87   ALA B CA    1 
ATOM   2648 C C     . ALA B 1 107 ? -26.81900 19.07900  -0.13500  1.000 34.00301  ? 87   ALA B C     1 
ATOM   2649 O O     . ALA B 1 107 ? -26.67600 17.87700  -0.32600  1.000 33.51857  ? 87   ALA B O     1 
ATOM   2650 C CB    . ALA B 1 107 ? -25.46400 20.72100  -1.44400  1.000 33.38368  ? 87   ALA B CB    1 
ATOM   2651 N N     . GLN B 1 108 ? -28.00300 19.65400  0.05000   1.000 33.90292  ? 88   GLN B N     1 
ATOM   2652 C CA    . GLN B 1 108 ? -29.26100 18.93000  -0.07200  1.000 33.30282  ? 88   GLN B CA    1 
ATOM   2653 C C     . GLN B 1 108 ? -29.86600 19.01100  -1.46900  1.000 36.69310  ? 88   GLN B C     1 
ATOM   2654 O O     . GLN B 1 108 ? -30.83100 18.29200  -1.74300  1.000 33.51793  ? 88   GLN B O     1 
ATOM   2655 C CB    . GLN B 1 108 ? -30.26600 19.47300  0.94600   1.000 34.97714  ? 88   GLN B CB    1 
ATOM   2656 C CG    . GLN B 1 108 ? -29.82400 19.28900  2.41100   1.000 36.57187  ? 88   GLN B CG    1 
ATOM   2657 C CD    . GLN B 1 108 ? -29.80500 17.83600  2.84000   1.000 34.31962  ? 88   GLN B CD    1 
ATOM   2658 O OE1   . GLN B 1 108 ? -30.72500 17.07800  2.52600   1.000 37.48924  ? 88   GLN B OE1   1 
ATOM   2659 N NE2   . GLN B 1 108 ? -28.75600 17.43300  3.53900   1.000 34.88575  ? 88   GLN B NE2   1 
ATOM   2660 N N     . VAL B 1 109 ? -29.35400 19.87700  -2.34800  1.000 30.78641  ? 89   VAL B N     1 
ATOM   2661 C CA    . VAL B 1 109 ? -29.82600 20.01000  -3.72300  1.000 28.19402  ? 89   VAL B CA    1 
ATOM   2662 C C     . VAL B 1 109 ? -28.60900 19.90600  -4.63700  1.000 31.06415  ? 89   VAL B C     1 
ATOM   2663 O O     . VAL B 1 109 ? -27.63300 20.64200  -4.45500  1.000 33.08758  ? 89   VAL B O     1 
ATOM   2664 C CB    . VAL B 1 109 ? -30.54500 21.35900  -3.95600  1.000 31.21092  ? 89   VAL B CB    1 
ATOM   2665 C CG1   . VAL B 1 109 ? -30.99000 21.47100  -5.37900  1.000 32.96760  ? 89   VAL B CG1   1 
ATOM   2666 C CG2   . VAL B 1 109 ? -31.71600 21.51200  -3.03400  1.000 31.44993  ? 89   VAL B CG2   1 
ATOM   2667 N N     . LEU B 1 110 ? -28.65300 18.99800  -5.60700  1.000 30.51683  ? 90   LEU B N     1 
ATOM   2668 C CA    . LEU B 1 110 ? -27.61200 18.92400  -6.62500  1.000 28.90050  ? 90   LEU B CA    1 
ATOM   2669 C C     . LEU B 1 110 ? -28.29300 18.66900  -7.95000  1.000 34.78648  ? 90   LEU B C     1 
ATOM   2670 O O     . LEU B 1 110 ? -29.39800 18.11300  -7.99100  1.000 33.37063  ? 90   LEU B O     1 
ATOM   2671 C CB    . LEU B 1 110 ? -26.58500 17.79700  -6.36700  1.000 29.82729  ? 90   LEU B CB    1 
ATOM   2672 C CG    . LEU B 1 110 ? -25.87000 17.73300  -5.00900  1.000 35.58442  ? 90   LEU B CG    1 
ATOM   2673 C CD1   . LEU B 1 110 ? -26.75000 17.07300  -3.89100  1.000 33.25465  ? 90   LEU B CD1   1 
ATOM   2674 C CD2   . LEU B 1 110 ? -24.49900 17.03400  -5.14100  1.000 33.88740  ? 90   LEU B CD2   1 
ATOM   2675 N N     . GLY B 1 111 ? -27.61900 19.01100  -9.03300  1.000 32.11108  ? 91   GLY B N     1 
ATOM   2676 C CA    . GLY B 1 111 ? -28.16500 18.78800  -10.36300 1.000 29.31689  ? 91   GLY B CA    1 
ATOM   2677 C C     . GLY B 1 111 ? -27.13700 18.19700  -11.29600 1.000 34.69562  ? 91   GLY B C     1 
ATOM   2678 O O     . GLY B 1 111 ? -25.96300 18.58900  -11.27100 1.000 30.79108  ? 91   GLY B O     1 
ATOM   2679 N N     . VAL B 1 112 ? -27.58400 17.24500  -12.12700 1.000 28.82479  ? 92   VAL B N     1 
ATOM   2680 C CA    . VAL B 1 112 ? -26.76400 16.72000  -13.21300 1.000 31.59933  ? 92   VAL B CA    1 
ATOM   2681 C C     . VAL B 1 112 ? -27.17300 17.46900  -14.46800 1.000 35.82516  ? 92   VAL B C     1 
ATOM   2682 O O     . VAL B 1 112 ? -28.31800 17.36200  -14.93300 1.000 35.03531  ? 92   VAL B O     1 
ATOM   2683 C CB    . VAL B 1 112 ? -26.93100 15.20700  -13.38300 1.000 34.23574  ? 92   VAL B CB    1 
ATOM   2684 C CG1   . VAL B 1 112 ? -26.08100 14.69600  -14.54400 1.000 39.55147  ? 92   VAL B CG1   1 
ATOM   2685 C CG2   . VAL B 1 112 ? -26.52800 14.50100  -12.09000 1.000 37.33346  ? 92   VAL B CG2   1 
ATOM   2686 N N     . PHE B 1 113 ? -26.26400 18.27900  -15.00000 1.000 35.95059  ? 93   PHE B N     1 
ATOM   2687 C CA    . PHE B 1 113 ? -26.58400 19.07800  -16.16900 1.000 34.84443  ? 93   PHE B CA    1 
ATOM   2688 C C     . PHE B 1 113 ? -25.75800 18.57300  -17.34700 1.000 39.07344  ? 93   PHE B C     1 
ATOM   2689 O O     . PHE B 1 113 ? -24.71100 17.93300  -17.18700 1.000 39.23774  ? 93   PHE B O     1 
ATOM   2690 C CB    . PHE B 1 113 ? -26.30200 20.57800  -15.94600 1.000 30.74097  ? 93   PHE B CB    1 
ATOM   2691 C CG    . PHE B 1 113 ? -27.21500 21.28300  -14.95000 1.000 32.52461  ? 93   PHE B CG    1 
ATOM   2692 C CD1   . PHE B 1 113 ? -26.99600 21.20200  -13.56900 1.000 29.54855  ? 93   PHE B CD1   1 
ATOM   2693 C CD2   . PHE B 1 113 ? -28.22400 22.12800  -15.40400 1.000 31.45763  ? 93   PHE B CD2   1 
ATOM   2694 C CE1   . PHE B 1 113 ? -27.80900 21.90600  -12.67100 1.000 25.37046  ? 93   PHE B CE1   1 
ATOM   2695 C CE2   . PHE B 1 113 ? -29.02000 22.83000  -14.51800 1.000 28.41273  ? 93   PHE B CE2   1 
ATOM   2696 C CZ    . PHE B 1 113 ? -28.82000 22.70100  -13.14000 1.000 26.97518  ? 93   PHE B CZ    1 
ATOM   2697 N N     . ARG B 1 114 ? -26.23100 18.89000  -18.54100 1.000 37.25495  ? 94   ARG B N     1 
ATOM   2698 C CA    . ARG B 1 114 ? -25.45100 18.63100  -19.74000 1.000 43.36938  ? 94   ARG B CA    1 
ATOM   2699 C C     . ARG B 1 114 ? -24.30000 19.64100  -19.86800 1.000 41.40302  ? 94   ARG B C     1 
ATOM   2700 O O     . ARG B 1 114 ? -24.46700 20.82700  -19.57700 1.000 41.44525  ? 94   ARG B O     1 
ATOM   2701 C CB    . ARG B 1 114 ? -26.38600 18.68800  -20.95200 1.000 44.93551  ? 94   ARG B CB    1 
ATOM   2702 C CG    . ARG B 1 114 ? -25.73800 18.24100  -22.23600 1.000 56.26944  ? 94   ARG B CG    1 
ATOM   2703 C CD    . ARG B 1 114 ? -26.78000 17.85500  -23.27700 1.000 65.85741  ? 94   ARG B CD    1 
ATOM   2704 N NE    . ARG B 1 114 ? -26.35900 18.24300  -24.62500 1.000 75.57592  ? 94   ARG B NE    1 
ATOM   2705 C CZ    . ARG B 1 114 ? -27.01200 17.92100  -25.74000 1.000 82.65099  ? 94   ARG B CZ    1 
ATOM   2706 N NH1   . ARG B 1 114 ? -28.12300 17.19200  -25.67900 1.000 85.20335  ? 94   ARG B NH1   1 
ATOM   2707 N NH2   . ARG B 1 114 ? -26.55100 18.32700  -26.92000 1.000 83.03335  ? 94   ARG B NH2   1 
ATOM   2708 N N     . LEU B 1 115 ? -23.10800 19.16200  -20.25400 1.000 42.23048  ? 95   LEU B N     1 
ATOM   2709 C CA    . LEU B 1 115 ? -21.97200 20.06400  -20.44300 1.000 44.47402  ? 95   LEU B CA    1 
ATOM   2710 C C     . LEU B 1 115 ? -22.26700 21.05200  -21.56700 1.000 48.95389  ? 95   LEU B C     1 
ATOM   2711 O O     . LEU B 1 115 ? -22.58100 20.63000  -22.68700 1.000 44.12434  ? 95   LEU B O     1 
ATOM   2712 C CB    . LEU B 1 115 ? -20.68500 19.31300  -20.77800 1.000 42.86646  ? 95   LEU B CB    1 
ATOM   2713 C CG    . LEU B 1 115 ? -19.73500 18.99200  -19.63200 1.000 45.92095  ? 95   LEU B CG    1 
ATOM   2714 C CD1   . LEU B 1 115 ? -18.42700 18.35800  -20.11000 1.000 51.12198  ? 95   LEU B CD1   1 
ATOM   2715 C CD2   . LEU B 1 115 ? -19.45700 20.23900  -18.84200 1.000 41.33522  ? 95   LEU B CD2   1 
ATOM   2716 N N     . PRO B 1 116 ? -22.10500 22.38000  -21.31200 1.000 49.70246  ? 96   PRO B N     1 
ATOM   2717 C CA    . PRO B 1 116 ? -22.27700 23.36900  -22.35700 1.000 52.16536  ? 96   PRO B CA    1 
ATOM   2718 C C     . PRO B 1 116 ? -21.11000 23.29000  -23.31800 1.000 56.39045  ? 96   PRO B C     1 
ATOM   2719 O O     . PRO B 1 116 ? -19.98200 22.97800  -22.91500 1.000 51.06420  ? 96   PRO B O     1 
ATOM   2720 C CB    . PRO B 1 116 ? -22.26500 24.68600  -21.59500 1.000 49.29848  ? 96   PRO B CB    1 
ATOM   2721 C CG    . PRO B 1 116 ? -22.50900 24.31900  -20.16800 1.000 44.86665  ? 96   PRO B CG    1 
ATOM   2722 C CD    . PRO B 1 116 ? -21.74100 23.03800  -20.04300 1.000 43.48988  ? 96   PRO B CD    1 
ATOM   2723 N N     . ARG B 1 117 ? -21.38100 23.60000  -24.57900 1.000 61.45110  ? 97   ARG B N     1 
ATOM   2724 C CA    . ARG B 1 117 ? -20.30200 23.60500  -25.59300 1.000 66.14381  ? 97   ARG B CA    1 
ATOM   2725 C C     . ARG B 1 117 ? -20.38400 24.92800  -26.35000 1.000 60.27331  ? 97   ARG B C     1 
ATOM   2726 O O     . ARG B 1 117 ? -21.18600 25.00400  -27.29100 1.000 68.45658  ? 97   ARG B O     1 
ATOM   2727 C CB    . ARG B 1 117 ? -20.46600 22.39500  -26.51500 1.000 65.41650  ? 97   ARG B CB    1 
ATOM   2728 C CG    . ARG B 1 117 ? -20.19000 21.06800  -25.82100 1.000 67.51865  ? 97   ARG B CG    1 
ATOM   2729 C CD    . ARG B 1 117 ? -18.75400 20.96700  -25.32300 1.000 65.64720  ? 97   ARG B CD    1 
ATOM   2730 N NE    . ARG B 1 117 ? -18.67000 20.67900  -23.88800 1.000 65.64631  ? 97   ARG B NE    1 
ATOM   2731 C CZ    . ARG B 1 117 ? -17.56500 20.79100  -23.15800 1.000 70.64627  ? 97   ARG B CZ    1 
ATOM   2732 N NH1   . ARG B 1 117 ? -16.50800 20.05100  -23.44200 1.000 63.20664  ? 97   ARG B NH1   1 
ATOM   2733 N NH2   . ARG B 1 117 ? -17.52200 21.64100  -22.14500 1.000 63.30227  ? 97   ARG B NH2   1 
ATOM   2734 N N     . ARG B 1 118 ? -19.60700 25.92100  -25.92400 1.000 63.24476  ? 98   ARG B N     1 
ATOM   2735 C CA    . ARG B 1 118 ? -19.66600 27.27000  -26.55000 1.000 64.70540  ? 98   ARG B CA    1 
ATOM   2736 C C     . ARG B 1 118 ? -18.38600 27.55700  -27.34900 1.000 58.59179  ? 98   ARG B C     1 
ATOM   2737 O O     . ARG B 1 118 ? -17.28900 27.26900  -26.83900 1.000 58.03368  ? 98   ARG B O     1 
ATOM   2738 C CB    . ARG B 1 118 ? -19.84500 28.34900  -25.47900 1.000 59.41110  ? 98   ARG B CB    1 
ATOM   2739 C CG    . ARG B 1 118 ? -20.77000 29.48500  -25.88900 1.000 63.35151  ? 98   ARG B CG    1 
ATOM   2740 C CD    . ARG B 1 118 ? -21.53200 30.08800  -24.71800 1.000 62.89111  ? 98   ARG B CD    1 
ATOM   2741 N NE    . ARG B 1 118 ? -20.71100 30.95800  -23.86800 1.000 57.60393  ? 98   ARG B NE    1 
ATOM   2742 C CZ    . ARG B 1 118 ? -20.64500 30.87500  -22.54900 1.000 52.24916  ? 98   ARG B CZ    1 
ATOM   2743 N NH1   . ARG B 1 118 ? -19.72000 30.12300  -21.98200 1.000 50.62035  ? 98   ARG B NH1   1 
ATOM   2744 N NH2   . ARG B 1 118 ? -21.50100 31.54500  -21.80300 1.000 49.35981  ? 98   ARG B NH2   1 
ATOM   2745 N N     . SER B 1 119 ? -18.54200 28.11700  -28.54400 1.000 55.81739  ? 99   SER B N     1 
ATOM   2746 C CA    . SER B 1 119 ? -17.38000 28.49100  -29.37600 1.000 52.52311  ? 99   SER B CA    1 
ATOM   2747 C C     . SER B 1 119 ? -17.30300 30.01900  -29.45200 1.000 44.00106  ? 99   SER B C     1 
ATOM   2748 O O     . SER B 1 119 ? -18.34900 30.66800  -29.44100 1.000 44.74582  ? 99   SER B O     1 
ATOM   2749 C CB    . SER B 1 119 ? -17.50900 27.91000  -30.74700 1.000 55.01568  ? 99   SER B CB    1 
ATOM   2750 O OG    . SER B 1 119 ? -18.19200 28.80700  -31.60800 1.000 58.54354  ? 99   SER B OG    1 
ATOM   2751 N N     . LEU B 1 120 ? -16.09600 30.55000  -29.57000 1.000 44.21166  ? 100  LEU B N     1 
ATOM   2752 C CA    . LEU B 1 120 ? -15.93600 32.01200  -29.70500 1.000 43.35572  ? 100  LEU B CA    1 
ATOM   2753 C C     . LEU B 1 120 ? -16.36400 32.45300  -31.10100 1.000 49.11868  ? 100  LEU B C     1 
ATOM   2754 O O     . LEU B 1 120 ? -16.60200 33.65100  -31.28700 1.000 46.55683  ? 100  LEU B O     1 
ATOM   2755 C CB    . LEU B 1 120 ? -14.45300 32.28100  -29.49100 1.000 45.65005  ? 100  LEU B CB    1 
ATOM   2756 C CG    . LEU B 1 120 ? -14.00200 33.73900  -29.40800 1.000 43.21866  ? 100  LEU B CG    1 
ATOM   2757 C CD1   . LEU B 1 120 ? -14.56200 34.39100  -28.16400 1.000 40.54885  ? 100  LEU B CD1   1 
ATOM   2758 C CD2   . LEU B 1 120 ? -12.48800 33.75200  -29.38700 1.000 36.70846  ? 100  LEU B CD2   1 
ATOM   2759 N N     . ALA B 1 121 ? -16.51100 31.50800  -32.03400 1.000 52.44305  ? 101  ALA B N     1 
ATOM   2760 C CA    . ALA B 1 121 ? -16.71400 31.94800  -33.41000 1.000 50.39159  ? 101  ALA B CA    1 
ATOM   2761 C C     . ALA B 1 121 ? -17.86300 32.93500  -33.52800 1.000 53.81823  ? 101  ALA B C     1 
ATOM   2762 O O     . ALA B 1 121 ? -17.74300 33.96600  -34.20400 1.000 56.86355  ? 101  ALA B O     1 
ATOM   2763 C CB    . ALA B 1 121 ? -16.95400 30.73900  -34.31300 1.000 56.29035  ? 101  ALA B CB    1 
ATOM   2764 N N     . GLY B 1 122 ? -18.98300 32.66100  -32.86600 1.000 55.09384  ? 102  GLY B N     1 
ATOM   2765 C CA    . GLY B 1 122 ? -20.10100 33.57700  -33.02000 1.000 53.39305  ? 102  GLY B CA    1 
ATOM   2766 C C     . GLY B 1 122 ? -19.86500 34.95200  -32.42900 1.000 56.66456  ? 102  GLY B C     1 
ATOM   2767 O O     . GLY B 1 122 ? -20.43900 35.93200  -32.91700 1.000 59.05603  ? 102  GLY B O     1 
ATOM   2768 N N     . VAL B 1 123 ? -19.10800 34.99700  -31.33600 1.000 55.25316  ? 103  VAL B N     1 
ATOM   2769 C CA    . VAL B 1 123 ? -18.99400 36.22300  -30.49500 1.000 49.50887  ? 103  VAL B CA    1 
ATOM   2770 C C     . VAL B 1 123 ? -18.71800 37.51900  -31.25300 1.000 47.90242  ? 103  VAL B C     1 
ATOM   2771 O O     . VAL B 1 123 ? -17.75600 37.57700  -32.03900 1.000 45.00193  ? 103  VAL B O     1 
ATOM   2772 C CB    . VAL B 1 123 ? -17.97500 36.00000  -29.36100 1.000 48.73534  ? 103  VAL B CB    1 
ATOM   2773 C CG1   . VAL B 1 123 ? -17.91700 37.18200  -28.40300 1.000 46.89794  ? 103  VAL B CG1   1 
ATOM   2774 C CG2   . VAL B 1 123 ? -18.26400 34.71500  -28.60300 1.000 48.69715  ? 103  VAL B CG2   1 
ATOM   2775 N N     . THR B 1 124 ? -19.53700 38.51600  -30.95500 1.000 46.04948  ? 104  THR B N     1 
ATOM   2776 C CA    . THR B 1 124 ? -19.30700 39.85300  -31.49700 1.000 52.24259  ? 104  THR B CA    1 
ATOM   2777 C C     . THR B 1 124 ? -19.35700 40.77000  -30.30200 1.000 49.58030  ? 104  THR B C     1 
ATOM   2778 O O     . THR B 1 124 ? -20.26600 40.61900  -29.48300 1.000 53.59327  ? 104  THR B O     1 
ATOM   2779 C CB    . THR B 1 124 ? -20.37300 40.20300  -32.53200 1.000 52.95673  ? 104  THR B CB    1 
ATOM   2780 O OG1   . THR B 1 124 ? -21.61500 40.00200  -31.86600 1.000 59.34069  ? 104  THR B OG1   1 
ATOM   2781 C CG2   . THR B 1 124 ? -20.28400 39.33900  -33.77600 1.000 50.23431  ? 104  THR B CG2   1 
ATOM   2782 N N     . LEU B 1 125 ? -18.40200 41.67900  -30.20200 1.000 46.07413  ? 105  LEU B N     1 
ATOM   2783 C CA    . LEU B 1 125 ? -18.34600 42.58000  -29.03500 1.000 45.13426  ? 105  LEU B CA    1 
ATOM   2784 C C     . LEU B 1 125 ? -18.86500 43.95100  -29.45100 1.000 47.87914  ? 105  LEU B C     1 
ATOM   2785 O O     . LEU B 1 125 ? -18.91500 44.22600  -30.65500 1.000 49.78381  ? 105  LEU B O     1 
ATOM   2786 C CB    . LEU B 1 125 ? -16.91100 42.68000  -28.52900 1.000 39.23519  ? 105  LEU B CB    1 
ATOM   2787 C CG    . LEU B 1 125 ? -16.27600 41.40800  -27.97000 1.000 40.05079  ? 105  LEU B CG    1 
ATOM   2788 C CD1   . LEU B 1 125 ? -14.82200 41.73900  -27.72800 1.000 33.34460  ? 105  LEU B CD1   1 
ATOM   2789 C CD2   . LEU B 1 125 ? -16.95000 41.02000  -26.67100 1.000 42.59247  ? 105  LEU B CD2   1 
ATOM   2790 N N     . GLY B 1 126 ? -19.21900 44.77600  -28.47700 1.000 46.97478  ? 106  GLY B N     1 
ATOM   2791 C CA    . GLY B 1 126 ? -19.62900 46.14700  -28.78600 1.000 42.21494  ? 106  GLY B CA    1 
ATOM   2792 C C     . GLY B 1 126 ? -18.45300 47.07600  -29.01500 1.000 41.30968  ? 106  GLY B C     1 
ATOM   2793 O O     . GLY B 1 126 ? -17.33300 46.57900  -29.18500 1.000 40.40986  ? 106  GLY B O     1 
ATOM   2794 N N     . ALA B 1 127 ? -18.69400 48.38500  -28.95600 1.000 41.30846  ? 107  ALA B N     1 
ATOM   2795 C CA    . ALA B 1 127 ? -17.66300 49.39500  -29.29000 1.000 41.65359  ? 107  ALA B CA    1 
ATOM   2796 C C     . ALA B 1 127 ? -16.63800 49.61100  -28.17700 1.000 46.45052  ? 107  ALA B C     1 
ATOM   2797 O O     . ALA B 1 127 ? -15.52600 50.05400  -28.50000 1.000 45.92343  ? 107  ALA B O     1 
ATOM   2798 C CB    . ALA B 1 127 ? -18.35800 50.69300  -29.60300 1.000 46.17616  ? 107  ALA B CB    1 
ATOM   2799 N N     . ALA B 1 128 ? -17.02600 49.39100  -26.92200 1.000 35.60980  ? 108  ALA B N     1 
ATOM   2800 C CA    . ALA B 1 128 ? -16.08000 49.65700  -25.82200 1.000 40.48736  ? 108  ALA B CA    1 
ATOM   2801 C C     . ALA B 1 128 ? -16.13600 48.48600  -24.85000 1.000 39.44799  ? 108  ALA B C     1 
ATOM   2802 O O     . ALA B 1 128 ? -16.61000 48.64000  -23.72200 1.000 35.35691  ? 108  ALA B O     1 
ATOM   2803 C CB    . ALA B 1 128 ? -16.41300 50.96000  -25.15200 1.000 36.25857  ? 108  ALA B CB    1 
ATOM   2804 N N     . PRO B 1 129 ? -15.67100 47.28600  -25.25500 1.000 34.31965  ? 109  PRO B N     1 
ATOM   2805 C CA    . PRO B 1 129 ? -15.81300 46.14600  -24.37900 1.000 30.64446  ? 109  PRO B CA    1 
ATOM   2806 C C     . PRO B 1 129 ? -14.83600 46.13100  -23.23200 1.000 31.29629  ? 109  PRO B C     1 
ATOM   2807 O O     . PRO B 1 129 ? -13.83700 46.85300  -23.25900 1.000 27.17308  ? 109  PRO B O     1 
ATOM   2808 C CB    . PRO B 1 129 ? -15.56500 44.99700  -25.34600 1.000 31.07386  ? 109  PRO B CB    1 
ATOM   2809 C CG    . PRO B 1 129 ? -14.49600 45.51500  -26.25300 1.000 29.26160  ? 109  PRO B CG    1 
ATOM   2810 C CD    . PRO B 1 129 ? -14.96100 46.92500  -26.50400 1.000 32.50663  ? 109  PRO B CD    1 
ATOM   2811 N N     . LEU B 1 130 ? -15.15800 45.33600  -22.22700 1.000 29.10018  ? 110  LEU B N     1 
ATOM   2812 C CA    . LEU B 1 130 ? -14.26800 45.12800  -21.06800 1.000 25.36256  ? 110  LEU B CA    1 
ATOM   2813 C C     . LEU B 1 130 ? -13.88400 43.65300  -21.14400 1.000 24.30117  ? 110  LEU B C     1 
ATOM   2814 O O     . LEU B 1 130 ? -14.75100 42.80800  -20.92600 1.000 23.77874  ? 110  LEU B O     1 
ATOM   2815 C CB    . LEU B 1 130 ? -15.00000 45.47300  -19.77500 1.000 27.00882  ? 110  LEU B CB    1 
ATOM   2816 C CG    . LEU B 1 130 ? -14.23800 45.21900  -18.47500 1.000 31.76858  ? 110  LEU B CG    1 
ATOM   2817 C CD1   . LEU B 1 130 ? -12.90300 45.93100  -18.52300 1.000 26.59034  ? 110  LEU B CD1   1 
ATOM   2818 C CD2   . LEU B 1 130 ? -15.07500 45.71900  -17.31800 1.000 25.87226  ? 110  LEU B CD2   1 
ATOM   2819 N N     . VAL B 1 131 ? -12.63100 43.38600  -21.45600 1.000 20.93829  ? 111  VAL B N     1 
ATOM   2820 C CA    . VAL B 1 131 ? -12.21700 41.98300  -21.68700 1.000 22.36754  ? 111  VAL B CA    1 
ATOM   2821 C C     . VAL B 1 131 ? -11.06900 41.58400  -20.75500 1.000 21.60273  ? 111  VAL B C     1 
ATOM   2822 O O     . VAL B 1 131 ? -10.21100 42.41000  -20.46600 1.000 22.85338  ? 111  VAL B O     1 
ATOM   2823 C CB    . VAL B 1 131 ? -11.85400 41.70500  -23.16300 1.000 23.76136  ? 111  VAL B CB    1 
ATOM   2824 C CG1   . VAL B 1 131 ? -11.33500 40.29400  -23.39700 1.000 21.49355  ? 111  VAL B CG1   1 
ATOM   2825 C CG2   . VAL B 1 131 ? -13.00000 42.03200  -24.10900 1.000 24.19488  ? 111  VAL B CG2   1 
ATOM   2826 N N     . LEU B 1 132 ? -11.14700 40.36800  -20.26400 1.000 18.92161  ? 112  LEU B N     1 
ATOM   2827 C CA    . LEU B 1 132 ? -10.07800 39.79500  -19.46800 1.000 18.50218  ? 112  LEU B CA    1 
ATOM   2828 C C     . LEU B 1 132 ? -9.48000  38.62400  -20.21000 1.000 23.56599  ? 112  LEU B C     1 
ATOM   2829 O O     . LEU B 1 132 ? -10.21000 37.74500  -20.68300 1.000 23.34060  ? 112  LEU B O     1 
ATOM   2830 C CB    . LEU B 1 132 ? -10.63300 39.34500  -18.12000 1.000 24.50675  ? 112  LEU B CB    1 
ATOM   2831 C CG    . LEU B 1 132 ? -9.64600  38.81900  -17.10700 1.000 25.85384  ? 112  LEU B CG    1 
ATOM   2832 C CD1   . LEU B 1 132 ? -8.54100  39.84500  -16.78900 1.000 30.55394  ? 112  LEU B CD1   1 
ATOM   2833 C CD2   . LEU B 1 132 ? -10.51600 38.54300  -15.87600 1.000 24.15058  ? 112  LEU B CD2   1 
ATOM   2834 N N     . VAL B 1 133 ? -8.15500  38.57200  -20.26800 1.000 22.67177  ? 113  VAL B N     1 
ATOM   2835 C CA    . VAL B 1 133 ? -7.44500  37.48600  -20.90800 1.000 26.00656  ? 113  VAL B CA    1 
ATOM   2836 C C     . VAL B 1 133 ? -6.56200  36.83700  -19.86500 1.000 25.64000  ? 113  VAL B C     1 
ATOM   2837 O O     . VAL B 1 133 ? -5.61100  37.46800  -19.39400 1.000 31.58066  ? 113  VAL B O     1 
ATOM   2838 C CB    . VAL B 1 133 ? -6.60000  37.99000  -22.09500 1.000 22.20999  ? 113  VAL B CB    1 
ATOM   2839 C CG1   . VAL B 1 133 ? -5.92000  36.84500  -22.76500 1.000 24.21223  ? 113  VAL B CG1   1 
ATOM   2840 C CG2   . VAL B 1 133 ? -7.45800  38.77400  -23.03800 1.000 24.66145  ? 113  VAL B CG2   1 
ATOM   2841 N N     . LEU B 1 134 ? -6.84100  35.56500  -19.52300 1.000 23.55644  ? 114  LEU B N     1 
ATOM   2842 C CA    . LEU B 1 134 ? -6.09800  34.85200  -18.49200 1.000 25.85208  ? 114  LEU B CA    1 
ATOM   2843 C C     . LEU B 1 134 ? -5.14100  33.89800  -19.18200 1.000 30.95807  ? 114  LEU B C     1 
ATOM   2844 O O     . LEU B 1 134 ? -5.55800  32.92100  -19.80700 1.000 29.16258  ? 114  LEU B O     1 
ATOM   2845 C CB    . LEU B 1 134 ? -6.99700  34.08100  -17.50600 1.000 28.66242  ? 114  LEU B CB    1 
ATOM   2846 C CG    . LEU B 1 134 ? -8.12200  34.84200  -16.81800 1.000 30.79828  ? 114  LEU B CG    1 
ATOM   2847 C CD1   . LEU B 1 134 ? -8.96200  33.89000  -15.91700 1.000 28.18459  ? 114  LEU B CD1   1 
ATOM   2848 C CD2   . LEU B 1 134 ? -7.49700  35.95900  -16.02800 1.000 28.30632  ? 114  LEU B CD2   1 
ATOM   2849 N N     . LEU B 1 135 ? -3.86300  34.16500  -19.04000 1.000 35.55491  ? 115  LEU B N     1 
ATOM   2850 C CA    . LEU B 1 135 ? -2.84100  33.41900  -19.74700 1.000 38.29497  ? 115  LEU B CA    1 
ATOM   2851 C C     . LEU B 1 135 ? -2.21800  32.43500  -18.77400 1.000 36.92750  ? 115  LEU B C     1 
ATOM   2852 O O     . LEU B 1 135 ? -1.98300  32.78000  -17.61600 1.000 39.00866  ? 115  LEU B O     1 
ATOM   2853 C CB    . LEU B 1 135 ? -1.80000  34.39000  -20.30600 1.000 39.72574  ? 115  LEU B CB    1 
ATOM   2854 C CG    . LEU B 1 135 ? -2.37800  35.27200  -21.41700 1.000 39.39813  ? 115  LEU B CG    1 
ATOM   2855 C CD1   . LEU B 1 135 ? -1.44200  36.41700  -21.73900 1.000 45.52536  ? 115  LEU B CD1   1 
ATOM   2856 C CD2   . LEU B 1 135 ? -2.65500  34.41000  -22.67800 1.000 35.99034  ? 115  LEU B CD2   1 
ATOM   2857 N N     . GLY B 1 136 ? -1.97600  31.20800  -19.23200 1.000 36.56972  ? 116  GLY B N     1 
ATOM   2858 C CA    . GLY B 1 136 ? -1.40100  30.17800  -18.37300 1.000 39.59782  ? 116  GLY B CA    1 
ATOM   2859 C C     . GLY B 1 136 ? -2.45700  29.27900  -17.75100 1.000 43.35444  ? 116  GLY B C     1 
ATOM   2860 O O     . GLY B 1 136 ? -3.64800  29.31500  -18.09000 1.000 39.51344  ? 116  GLY B O     1 
ATOM   2861 N N     . LEU B 1 137 ? -2.00000  28.45200  -16.81800 1.000 41.29161  ? 117  LEU B N     1 
ATOM   2862 C CA    . LEU B 1 137 ? -2.93900  27.54100  -16.12200 1.000 46.15437  ? 117  LEU B CA    1 
ATOM   2863 C C     . LEU B 1 137 ? -3.08200  27.98100  -14.65700 1.000 41.57511  ? 117  LEU B C     1 
ATOM   2864 O O     . LEU B 1 137 ? -2.09700  27.95600  -13.91800 1.000 47.61434  ? 117  LEU B O     1 
ATOM   2865 C CB    . LEU B 1 137 ? -2.50300  26.08200  -16.25100 1.000 47.75105  ? 117  LEU B CB    1 
ATOM   2866 C CG    . LEU B 1 137 ? -2.74200  25.45400  -17.62700 1.000 53.44106  ? 117  LEU B CG    1 
ATOM   2867 C CD1   . LEU B 1 137 ? -2.50200  23.95800  -17.60600 1.000 52.22846  ? 117  LEU B CD1   1 
ATOM   2868 C CD2   . LEU B 1 137 ? -4.14000  25.76600  -18.12900 1.000 50.38537  ? 117  LEU B CD2   1 
ATOM   2869 N N     . GLU B 1 138 ? -4.28700  28.38400  -14.28700 1.000 42.83294  ? 118  GLU B N     1 
ATOM   2870 C CA    . GLU B 1 138 ? -4.53400  28.82800  -12.90000 1.000 40.36147  ? 118  GLU B CA    1 
ATOM   2871 C C     . GLU B 1 138 ? -5.12100  27.66200  -12.08800 1.000 37.42597  ? 118  GLU B C     1 
ATOM   2872 O O     . GLU B 1 138 ? -5.67400  26.74000  -12.69000 1.000 34.70723  ? 118  GLU B O     1 
ATOM   2873 C CB    . GLU B 1 138 ? -5.44600  30.05800  -12.90200 1.000 39.55709  ? 118  GLU B CB    1 
ATOM   2874 C CG    . GLU B 1 138 ? -5.60900  30.71500  -11.53500 1.000 39.91436  ? 118  GLU B CG    1 
ATOM   2875 C CD    . GLU B 1 138 ? -4.31200  31.07400  -10.83300 1.000 45.19322  ? 118  GLU B CD    1 
ATOM   2876 O OE1   . GLU B 1 138 ? -3.85000  30.33200  -9.94500  1.000 38.08202  ? 118  GLU B OE1   1 
ATOM   2877 O OE2   . GLU B 1 138 ? -3.76900  32.13000  -11.19000 1.000 48.58359  ? 118  GLU B OE2   1 
ATOM   2878 N N     . LYS B 1 139 ? -4.97400  27.72400  -10.77000 1.000 35.63343  ? 119  LYS B N     1 
ATOM   2879 C CA    . LYS B 1 139 ? -5.58700  26.71500  -9.88100  1.000 36.55525  ? 119  LYS B CA    1 
ATOM   2880 C C     . LYS B 1 139 ? -7.10900  26.89300  -9.92400  1.000 36.44388  ? 119  LYS B C     1 
ATOM   2881 O O     . LYS B 1 139 ? -7.59000  28.02900  -10.06200 1.000 30.78164  ? 119  LYS B O     1 
ATOM   2882 C CB    . LYS B 1 139 ? -5.03400  26.86400  -8.46500  1.000 38.93129  ? 119  LYS B CB    1 
ATOM   2883 C CG    . LYS B 1 139 ? -3.52200  26.98600  -8.39900  1.000 42.78453  ? 119  LYS B CG    1 
ATOM   2884 C CD    . LYS B 1 139 ? -2.95900  26.49300  -7.07400  1.000 46.75978  ? 119  LYS B CD    1 
ATOM   2885 C CE    . LYS B 1 139 ? -1.47000  26.57500  -7.02400  1.000 55.98670  ? 119  LYS B CE    1 
ATOM   2886 N NZ    . LYS B 1 139 ? -1.00800  27.92600  -6.69800  1.000 58.98654  ? 119  LYS B NZ    1 
ATOM   2887 N N     . PRO B 1 140 ? -7.87100  25.79300  -9.87400  1.000 34.20829  ? 120  PRO B N     1 
ATOM   2888 C CA    . PRO B 1 140 ? -9.33600  25.87600  -10.03000 1.000 33.76917  ? 120  PRO B CA    1 
ATOM   2889 C C     . PRO B 1 140 ? -9.98800  26.85200  -9.05800  1.000 31.71396  ? 120  PRO B C     1 
ATOM   2890 O O     . PRO B 1 140 ? -10.91900 27.58000  -9.43600  1.000 26.57263  ? 120  PRO B O     1 
ATOM   2891 C CB    . PRO B 1 140 ? -9.80500  24.42300  -9.79400  1.000 34.96884  ? 120  PRO B CB    1 
ATOM   2892 C CG    . PRO B 1 140 ? -8.51200  23.58700  -9.57000  1.000 36.53178  ? 120  PRO B CG    1 
ATOM   2893 C CD    . PRO B 1 140 ? -7.36100  24.42100  -10.03100 1.000 36.98255  ? 120  PRO B CD    1 
ATOM   2894 N N     . GLY B 1 141 ? -9.52700  26.88900  -7.81600  1.000 29.48281  ? 121  GLY B N     1 
ATOM   2895 C CA    . GLY B 1 141 ? -10.16300 27.76400  -6.81600  1.000 28.59704  ? 121  GLY B CA    1 
ATOM   2896 C C     . GLY B 1 141 ? -9.96000  29.22300  -7.16200  1.000 28.97117  ? 121  GLY B C     1 
ATOM   2897 O O     . GLY B 1 141 ? -10.92000 29.99100  -7.06600  1.000 25.03805  ? 121  GLY B O     1 
ATOM   2898 N N     . ASN B 1 142 ? -8.73900  29.58100  -7.55100  1.000 27.40719  ? 122  ASN B N     1 
ATOM   2899 C CA    . ASN B 1 142 ? -8.43900  30.97000  -7.96900  1.000 26.22178  ? 122  ASN B CA    1 
ATOM   2900 C C     . ASN B 1 142 ? -9.27400  31.32000  -9.20700  1.000 27.58019  ? 122  ASN B C     1 
ATOM   2901 O O     . ASN B 1 142 ? -9.84600  32.40700  -9.25300  1.000 24.11513  ? 122  ASN B O     1 
ATOM   2902 C CB    . ASN B 1 142 ? -6.94700  31.16000  -8.21400  1.000 27.61292  ? 122  ASN B CB    1 
ATOM   2903 C CG    . ASN B 1 142 ? -6.11100  30.98800  -6.96800  1.000 33.66801  ? 122  ASN B CG    1 
ATOM   2904 O OD1   . ASN B 1 142 ? -6.62500  31.07700  -5.85100  1.000 32.30932  ? 122  ASN B OD1   1 
ATOM   2905 N ND2   . ASN B 1 142 ? -4.82000  30.75000  -7.13900  1.000 35.16921  ? 122  ASN B ND2   1 
ATOM   2906 N N     . LEU B 1 143 ? -9.33900  30.40100  -10.16600 1.000 26.42440  ? 123  LEU B N     1 
ATOM   2907 C CA    . LEU B 1 143 ? -10.10400 30.66300  -11.40400 1.000 25.00433  ? 123  LEU B CA    1 
ATOM   2908 C C     . LEU B 1 143 ? -11.57000 30.97700  -11.03900 1.000 23.88555  ? 123  LEU B C     1 
ATOM   2909 O O     . LEU B 1 143 ? -12.12500 31.93200  -11.57900 1.000 19.58720  ? 123  LEU B O     1 
ATOM   2910 C CB    . LEU B 1 143 ? -10.00400 29.49300  -12.37400 1.000 23.65243  ? 123  LEU B CB    1 
ATOM   2911 C CG    . LEU B 1 143 ? -10.85900 29.59900  -13.63900 1.000 26.55405  ? 123  LEU B CG    1 
ATOM   2912 C CD1   . LEU B 1 143 ? -10.40600 30.75600  -14.50200 1.000 30.13704  ? 123  LEU B CD1   1 
ATOM   2913 C CD2   . LEU B 1 143 ? -10.81400 28.30900  -14.42600 1.000 29.58102  ? 123  LEU B CD2   1 
ATOM   2914 N N     . GLY B 1 144 ? -12.14500 30.17200  -10.15200 1.000 21.99021  ? 124  GLY B N     1 
ATOM   2915 C CA    . GLY B 1 144 ? -13.54200 30.44500  -9.81600  1.000 22.61960  ? 124  GLY B CA    1 
ATOM   2916 C C     . GLY B 1 144 ? -13.71200 31.83400  -9.23800  1.000 22.43197  ? 124  GLY B C     1 
ATOM   2917 O O     . GLY B 1 144 ? -14.64900 32.55300  -9.57500  1.000 20.97198  ? 124  GLY B O     1 
ATOM   2918 N N     . ALA B 1 145 ? -12.77500 32.24700  -8.38100  1.000 22.04586  ? 125  ALA B N     1 
ATOM   2919 C CA    . ALA B 1 145 ? -12.84300 33.58800  -7.79900  1.000 24.58383  ? 125  ALA B CA    1 
ATOM   2920 C C     . ALA B 1 145 ? -12.64900 34.67700  -8.85300  1.000 21.34087  ? 125  ALA B C     1 
ATOM   2921 O O     . ALA B 1 145 ? -13.32600 35.70700  -8.81000  1.000 21.97580  ? 125  ALA B O     1 
ATOM   2922 C CB    . ALA B 1 145 ? -11.80600 33.71600  -6.66600  1.000 24.26721  ? 125  ALA B CB    1 
ATOM   2923 N N     . ILE B 1 146 ? -11.72900 34.48300  -9.80800  1.000 21.81334  ? 126  ILE B N     1 
ATOM   2924 C CA    . ILE B 1 146 ? -11.57100 35.45300  -10.89500 1.000 22.58408  ? 126  ILE B CA    1 
ATOM   2925 C C     . ILE B 1 146 ? -12.87800 35.63100  -11.64800 1.000 22.26684  ? 126  ILE B C     1 
ATOM   2926 O O     . ILE B 1 146 ? -13.29800 36.74800  -11.95600 1.000 21.49389  ? 126  ILE B O     1 
ATOM   2927 C CB    . ILE B 1 146 ? -10.45200 35.00700  -11.86100 1.000 25.32198  ? 126  ILE B CB    1 
ATOM   2928 C CG1   . ILE B 1 146 ? -9.11500  34.88300  -11.11500 1.000 26.48060  ? 126  ILE B CG1   1 
ATOM   2929 C CG2   . ILE B 1 146 ? -10.37000 35.98100  -13.04300 1.000 21.62366  ? 126  ILE B CG2   1 
ATOM   2930 C CD1   . ILE B 1 146 ? -8.00200  34.20900  -11.94600 1.000 29.85032  ? 126  ILE B CD1   1 
ATOM   2931 N N     . LEU B 1 147 ? -13.53300 34.51800  -11.98200 1.000 21.14416  ? 127  LEU B N     1 
ATOM   2932 C CA    . LEU B 1 147 ? -14.75200 34.58800  -12.77600 1.000 21.21684  ? 127  LEU B CA    1 
ATOM   2933 C C     . LEU B 1 147 ? -15.87700 35.26400  -12.01400 1.000 21.65812  ? 127  LEU B C     1 
ATOM   2934 O O     . LEU B 1 147 ? -16.72100 35.93400  -12.61700 1.000 22.21192  ? 127  LEU B O     1 
ATOM   2935 C CB    . LEU B 1 147 ? -15.15900 33.17700  -13.19300 1.000 23.08883  ? 127  LEU B CB    1 
ATOM   2936 C CG    . LEU B 1 147 ? -14.12000 32.44000  -14.07000 1.000 24.42020  ? 127  LEU B CG    1 
ATOM   2937 C CD1   . LEU B 1 147 ? -14.80600 31.22700  -14.59200 1.000 25.30698  ? 127  LEU B CD1   1 
ATOM   2938 C CD2   . LEU B 1 147 ? -13.60800 33.32000  -15.24800 1.000 22.81985  ? 127  LEU B CD2   1 
ATOM   2939 N N     . ARG B 1 148 ? -15.89400 35.13900  -10.69300 1.000 24.29737  ? 128  ARG B N     1 
ATOM   2940 C CA    . ARG B 1 148 ? -16.91200 35.87600  -9.90500  1.000 19.54394  ? 128  ARG B CA    1 
ATOM   2941 C C     . ARG B 1 148 ? -16.62600 37.37900  -10.03500 1.000 20.12406  ? 128  ARG B C     1 
ATOM   2942 O O     . ARG B 1 148 ? -17.55500 38.15400  -10.23900 1.000 24.30367  ? 128  ARG B O     1 
ATOM   2943 C CB    . ARG B 1 148 ? -16.92500 35.45400  -8.43100  1.000 24.21545  ? 128  ARG B CB    1 
ATOM   2944 C CG    . ARG B 1 148 ? -17.97000 36.12900  -7.56000  1.000 22.01805  ? 128  ARG B CG    1 
ATOM   2945 C CD    . ARG B 1 148 ? -17.88800 35.61900  -6.13800  1.000 21.81574  ? 128  ARG B CD    1 
ATOM   2946 N NE    . ARG B 1 148 ? -18.87000 36.27200  -5.27100  1.000 24.08326  ? 128  ARG B NE    1 
ATOM   2947 C CZ    . ARG B 1 148 ? -18.98700 36.04300  -3.97600  1.000 25.51562  ? 128  ARG B CZ    1 
ATOM   2948 N NH1   . ARG B 1 148 ? -18.15600 35.21400  -3.37700  1.000 21.73811  ? 128  ARG B NH1   1 
ATOM   2949 N NH2   . ARG B 1 148 ? -19.94000 36.64200  -3.29000  1.000 27.57456  ? 128  ARG B NH2   1 
ATOM   2950 N N     . ALA B 1 149 ? -15.35500 37.74400  -9.89100  1.000 17.97325  ? 129  ALA B N     1 
ATOM   2951 C CA    . ALA B 1 149 ? -15.01500 39.17200  -10.04400 1.000 20.76298  ? 129  ALA B CA    1 
ATOM   2952 C C     . ALA B 1 149 ? -15.40800 39.65500  -11.44400 1.000 19.85403  ? 129  ALA B C     1 
ATOM   2953 O O     . ALA B 1 149 ? -16.02800 40.70600  -11.57800 1.000 24.63529  ? 129  ALA B O     1 
ATOM   2954 C CB    . ALA B 1 149 ? -13.56100 39.37900  -9.76500  1.000 23.84597  ? 129  ALA B CB    1 
ATOM   2955 N N     . ALA B 1 150 ? -15.06500 38.86800  -12.45200 1.000 22.32102  ? 130  ALA B N     1 
ATOM   2956 C CA    . ALA B 1 150 ? -15.39300 39.28800  -13.81500 1.000 20.31182  ? 130  ALA B CA    1 
ATOM   2957 C C     . ALA B 1 150 ? -16.89500 39.47900  -13.99100 1.000 20.57409  ? 130  ALA B C     1 
ATOM   2958 O O     . ALA B 1 150 ? -17.34100 40.47100  -14.57900 1.000 22.20631  ? 130  ALA B O     1 
ATOM   2959 C CB    . ALA B 1 150 ? -14.84700 38.26400  -14.82000 1.000 22.64932  ? 130  ALA B CB    1 
ATOM   2960 N N     . ASP B 1 151 ? -17.68900 38.58300  -13.41300 1.000 24.30314  ? 131  ASP B N     1 
ATOM   2961 C CA    . ASP B 1 151 ? -19.15100 38.69600  -13.46400 1.000 24.13092  ? 131  ASP B CA    1 
ATOM   2962 C C     . ASP B 1 151 ? -19.63800 39.94400  -12.73900 1.000 26.65603  ? 131  ASP B C     1 
ATOM   2963 O O     . ASP B 1 151 ? -20.46800 40.70400  -13.26800 1.000 27.29831  ? 131  ASP B O     1 
ATOM   2964 C CB    . ASP B 1 151 ? -19.78900 37.44800  -12.84600 1.000 30.23188  ? 131  ASP B CB    1 
ATOM   2965 C CG    . ASP B 1 151 ? -21.28500 37.61400  -12.62000 1.000 35.22557  ? 131  ASP B CG    1 
ATOM   2966 O OD1   . ASP B 1 151 ? -22.04700 37.29000  -13.56900 1.000 32.39220  ? 131  ASP B OD1   1 
ATOM   2967 O OD2   . ASP B 1 151 ? -21.69800 38.09300  -11.51200 1.000 31.86687  ? 131  ASP B OD2   1 
ATOM   2968 N N     . GLY B 1 152 ? -19.09900 40.20200  -11.56100 1.000 25.61258  ? 132  GLY B N     1 
ATOM   2969 C CA    . GLY B 1 152 ? -19.46400 41.41700  -10.81800 1.000 26.95166  ? 132  GLY B CA    1 
ATOM   2970 C C     . GLY B 1 152 ? -19.23200 42.68300  -11.61400 1.000 28.69172  ? 132  GLY B C     1 
ATOM   2971 O O     . GLY B 1 152 ? -20.09600 43.56300  -11.58300 1.000 26.17887  ? 132  GLY B O     1 
ATOM   2972 N N     . ALA B 1 153 ? -18.08500 42.78400  -12.27500 1.000 23.21734  ? 133  ALA B N     1 
ATOM   2973 C CA    . ALA B 1 153 ? -17.73700 44.01900  -13.01000 1.000 26.93906  ? 133  ALA B CA    1 
ATOM   2974 C C     . ALA B 1 153 ? -18.42100 44.07000  -14.37700 1.000 26.88711  ? 133  ALA B C     1 
ATOM   2975 O O     . ALA B 1 153 ? -18.28200 45.08100  -15.06100 1.000 28.22635  ? 133  ALA B O     1 
ATOM   2976 C CB    . ALA B 1 153 ? -16.25200 44.08500  -13.15100 1.000 24.54357  ? 133  ALA B CB    1 
ATOM   2977 N N     . GLY B 1 154 ? -19.14900 43.01900  -14.73700 1.000 27.61273  ? 134  GLY B N     1 
ATOM   2978 C CA    . GLY B 1 154 ? -19.79400 42.95000  -16.04700 1.000 30.30935  ? 134  GLY B CA    1 
ATOM   2979 C C     . GLY B 1 154 ? -18.83400 42.83600  -17.22000 1.000 29.20685  ? 134  GLY B C     1 
ATOM   2980 O O     . GLY B 1 154 ? -19.04900 43.48100  -18.24900 1.000 29.84933  ? 134  GLY B O     1 
ATOM   2981 N N     . ALA B 1 155 ? -17.78600 42.03100  -17.09400 1.000 24.30730  ? 135  ALA B N     1 
ATOM   2982 C CA    . ALA B 1 155 ? -16.88900 41.83400  -18.22000 1.000 25.62636  ? 135  ALA B CA    1 
ATOM   2983 C C     . ALA B 1 155 ? -17.66700 41.26400  -19.39600 1.000 28.35341  ? 135  ALA B C     1 
ATOM   2984 O O     . ALA B 1 155 ? -18.47300 40.34500  -19.24100 1.000 28.00152  ? 135  ALA B O     1 
ATOM   2985 C CB    . ALA B 1 155 ? -15.75200 40.90300  -17.84400 1.000 23.72890  ? 135  ALA B CB    1 
ATOM   2986 N N     . ASP B 1 156 ? -17.38300 41.78700  -20.57900 1.000 25.22848  ? 136  ASP B N     1 
ATOM   2987 C CA    . ASP B 1 156 ? -18.08200 41.34400  -21.80800 1.000 28.93764  ? 136  ASP B CA    1 
ATOM   2988 C C     . ASP B 1 156 ? -17.50100 40.01700  -22.29600 1.000 29.59767  ? 136  ASP B C     1 
ATOM   2989 O O     . ASP B 1 156 ? -18.18200 39.32200  -23.05500 1.000 30.76063  ? 136  ASP B O     1 
ATOM   2990 C CB    . ASP B 1 156 ? -17.98900 42.42700  -22.86500 1.000 28.16713  ? 136  ASP B CB    1 
ATOM   2991 C CG    . ASP B 1 156 ? -18.54900 43.77100  -22.44200 1.000 28.23233  ? 136  ASP B CG    1 
ATOM   2992 O OD1   . ASP B 1 156 ? -19.78100 43.90000  -22.42400 1.000 33.56652  ? 136  ASP B OD1   1 
ATOM   2993 O OD2   . ASP B 1 156 ? -17.74600 44.65700  -22.12100 1.000 30.91296  ? 136  ASP B OD2   1 
ATOM   2994 N N     . LEU B 1 157 ? -16.28200 39.70100  -21.86900 1.000 22.83274  ? 137  LEU B N     1 
ATOM   2995 C CA    . LEU B 1 157 ? -15.63200 38.48400  -22.38300 1.000 22.61147  ? 137  LEU B CA    1 
ATOM   2996 C C     . LEU B 1 157 ? -14.42200 38.11400  -21.54200 1.000 23.79840  ? 137  LEU B C     1 
ATOM   2997 O O     . LEU B 1 157 ? -13.64700 38.99400  -21.18500 1.000 24.32111  ? 137  LEU B O     1 
ATOM   2998 C CB    . LEU B 1 157 ? -15.20700 38.69400  -23.83400 1.000 26.29570  ? 137  LEU B CB    1 
ATOM   2999 C CG    . LEU B 1 157 ? -14.45600 37.54700  -24.51000 1.000 27.97968  ? 137  LEU B CG    1 
ATOM   3000 C CD1   . LEU B 1 157 ? -15.46900 36.56500  -25.04400 1.000 33.66230  ? 137  LEU B CD1   1 
ATOM   3001 C CD2   . LEU B 1 157 ? -13.62200 38.10500  -25.64100 1.000 30.78576  ? 137  LEU B CD2   1 
ATOM   3002 N N     . VAL B 1 158 ? -14.32100 36.84000  -21.23700 1.000 21.39862  ? 138  VAL B N     1 
ATOM   3003 C CA    . VAL B 1 158 ? -13.11500 36.33600  -20.60400 1.000 22.23934  ? 138  VAL B CA    1 
ATOM   3004 C C     . VAL B 1 158 ? -12.54800 35.21700  -21.47400 1.000 26.76286  ? 138  VAL B C     1 
ATOM   3005 O O     . VAL B 1 158 ? -13.26900 34.28000  -21.83500 1.000 24.66316  ? 138  VAL B O     1 
ATOM   3006 C CB    . VAL B 1 158 ? -13.40700 35.83900  -19.17200 1.000 25.23128  ? 138  VAL B CB    1 
ATOM   3007 C CG1   . VAL B 1 158 ? -12.13100 35.29600  -18.55000 1.000 21.09780  ? 138  VAL B CG1   1 
ATOM   3008 C CG2   . VAL B 1 158 ? -14.10100 36.98400  -18.34000 1.000 19.86070  ? 138  VAL B CG2   1 
ATOM   3009 N N     . LEU B 1 159 ? -11.26400 35.30600  -21.80600 1.000 21.82662  ? 139  LEU B N     1 
ATOM   3010 C CA    . LEU B 1 159 ? -10.55100 34.27100  -22.55800 1.000 23.81893  ? 139  LEU B CA    1 
ATOM   3011 C C     . LEU B 1 159 ? -9.59900  33.55800  -21.61600 1.000 25.01704  ? 139  LEU B C     1 
ATOM   3012 O O     . LEU B 1 159 ? -8.88900  34.21400  -20.85300 1.000 27.68632  ? 139  LEU B O     1 
ATOM   3013 C CB    . LEU B 1 159 ? -9.77200  34.87800  -23.74700 1.000 24.22985  ? 139  LEU B CB    1 
ATOM   3014 C CG    . LEU B 1 159 ? -10.60600 35.64600  -24.76900 1.000 27.57185  ? 139  LEU B CG    1 
ATOM   3015 C CD1   . LEU B 1 159 ? -9.75700  36.38600  -25.83000 1.000 28.13693  ? 139  LEU B CD1   1 
ATOM   3016 C CD2   . LEU B 1 159 ? -11.62700 34.71800  -25.42400 1.000 27.77686  ? 139  LEU B CD2   1 
ATOM   3017 N N     . VAL B 1 160 ? -9.58900  32.22000  -21.64800 1.000 25.36362  ? 140  VAL B N     1 
ATOM   3018 C CA    . VAL B 1 160 ? -8.71200  31.40800  -20.81000 1.000 22.18722  ? 140  VAL B CA    1 
ATOM   3019 C C     . VAL B 1 160 ? -8.04000  30.37300  -21.72600 1.000 26.76226  ? 140  VAL B C     1 
ATOM   3020 O O     . VAL B 1 160 ? -8.36500  30.26700  -22.90900 1.000 29.90959  ? 140  VAL B O     1 
ATOM   3021 C CB    . VAL B 1 160 ? -9.46700  30.70300  -19.65800 1.000 28.07842  ? 140  VAL B CB    1 
ATOM   3022 C CG1   . VAL B 1 160 ? -10.33400 31.69900  -18.81400 1.000 24.26774  ? 140  VAL B CG1   1 
ATOM   3023 C CG2   . VAL B 1 160 ? -10.34800 29.60600  -20.25800 1.000 25.42684  ? 140  VAL B CG2   1 
ATOM   3024 N N     . ALA B 1 161 ? -7.10800  29.59900  -21.17000 1.000 28.67808  ? 141  ALA B N     1 
ATOM   3025 C CA    . ALA B 1 161 ? -6.28000  28.71400  -22.00500 1.000 32.70539  ? 141  ALA B CA    1 
ATOM   3026 C C     . ALA B 1 161 ? -7.07900  27.52200  -22.52900 1.000 32.17360  ? 141  ALA B C     1 
ATOM   3027 O O     . ALA B 1 161 ? -8.13100  27.15700  -21.99700 1.000 28.98383  ? 141  ALA B O     1 
ATOM   3028 C CB    . ALA B 1 161 ? -5.05800  28.21600  -21.24300 1.000 28.94635  ? 141  ALA B CB    1 
ATOM   3029 N N     . GLU B 1 162 ? -6.54900  26.90400  -23.60000 1.000 36.06697  ? 142  GLU B N     1 
ATOM   3030 C CA    . GLU B 1 162 ? -7.31500  25.92100  -24.36700 1.000 34.26562  ? 142  GLU B CA    1 
ATOM   3031 C C     . GLU B 1 162 ? -7.80900  24.76300  -23.49100 1.000 35.17585  ? 142  GLU B C     1 
ATOM   3032 O O     . GLU B 1 162 ? -8.93900  24.29600  -23.63500 1.000 37.83939  ? 142  GLU B O     1 
ATOM   3033 C CB    . GLU B 1 162 ? -6.45500  25.40400  -25.53700 1.000 38.37198  ? 142  GLU B CB    1 
ATOM   3034 C CG    . GLU B 1 162 ? -7.17300  24.49200  -26.50600 1.000 44.29521  ? 142  GLU B CG    1 
ATOM   3035 C CD    . GLU B 1 162 ? -6.43100  24.35500  -27.85500 1.000 54.41268  ? 142  GLU B CD    1 
ATOM   3036 O OE1   . GLU B 1 162 ? -5.17000  24.25100  -27.86000 1.000 54.34525  ? 142  GLU B OE1   1 
ATOM   3037 O OE2   . GLU B 1 162 ? -7.11600  24.37300  -28.91200 1.000 58.15831  ? 142  GLU B OE2   1 
ATOM   3038 N N     . GLY B 1 163 ? -6.99700  24.27900  -22.58200 1.000 32.93456  ? 143  GLY B N     1 
ATOM   3039 C CA    . GLY B 1 163 ? -7.44400  23.08700  -21.89000 1.000 36.50620  ? 143  GLY B CA    1 
ATOM   3040 C C     . GLY B 1 163 ? -8.16800  23.33000  -20.58400 1.000 38.67415  ? 143  GLY B C     1 
ATOM   3041 O O     . GLY B 1 163 ? -8.44400  22.35900  -19.86600 1.000 35.85103  ? 143  GLY B O     1 
ATOM   3042 N N     . VAL B 1 164 ? -8.49200  24.58900  -20.26200 1.000 30.94850  ? 144  VAL B N     1 
ATOM   3043 C CA    . VAL B 1 164 ? -9.06500  24.93100  -18.96700 1.000 28.61896  ? 144  VAL B CA    1 
ATOM   3044 C C     . VAL B 1 164 ? -10.43200 24.27500  -18.77700 1.000 29.80793  ? 144  VAL B C     1 
ATOM   3045 O O     . VAL B 1 164 ? -11.29800 24.32200  -19.66100 1.000 32.11986  ? 144  VAL B O     1 
ATOM   3046 C CB    . VAL B 1 164 ? -9.18300  26.45800  -18.84700 1.000 33.33071  ? 144  VAL B CB    1 
ATOM   3047 C CG1   . VAL B 1 164 ? -10.09000 26.84200  -17.63500 1.000 25.88151  ? 144  VAL B CG1   1 
ATOM   3048 C CG2   . VAL B 1 164 ? -7.78800  27.09300  -18.73900 1.000 31.92011  ? 144  VAL B CG2   1 
ATOM   3049 N N     . ASP B 1 165 ? -10.65400 23.73200  -17.58200 1.000 31.19336  ? 145  ASP B N     1 
ATOM   3050 C CA    . ASP B 1 165 ? -11.92700 23.11400  -17.22000 1.000 33.98264  ? 145  ASP B CA    1 
ATOM   3051 C C     . ASP B 1 165 ? -12.76400 24.10300  -16.40700 1.000 28.70699  ? 145  ASP B C     1 
ATOM   3052 O O     . ASP B 1 165 ? -12.46600 24.36800  -15.23500 1.000 31.63174  ? 145  ASP B O     1 
ATOM   3053 C CB    . ASP B 1 165 ? -11.66000 21.83100  -16.44200 1.000 35.64383  ? 145  ASP B CB    1 
ATOM   3054 C CG    . ASP B 1 165 ? -12.93400 21.10300  -16.05100 1.000 35.08885  ? 145  ASP B CG    1 
ATOM   3055 O OD1   . ASP B 1 165 ? -14.03200 21.48300  -16.52200 1.000 33.41782  ? 145  ASP B OD1   1 
ATOM   3056 O OD2   . ASP B 1 165 ? -12.80300 20.15400  -15.26500 1.000 34.86645  ? 145  ASP B OD2   1 
ATOM   3057 N N     . LEU B 1 166 ? -13.82700 24.60500  -17.01400 1.000 26.16826  ? 146  LEU B N     1 
ATOM   3058 C CA    . LEU B 1 166 ? -14.73600 25.55900  -16.37400 1.000 28.77869  ? 146  LEU B CA    1 
ATOM   3059 C C     . LEU B 1 166 ? -15.80200 24.90000  -15.50400 1.000 33.58783  ? 146  LEU B C     1 
ATOM   3060 O O     . LEU B 1 166 ? -16.57600 25.60800  -14.83900 1.000 34.61607  ? 146  LEU B O     1 
ATOM   3061 C CB    . LEU B 1 166 ? -15.42000 26.39300  -17.44700 1.000 28.51207  ? 146  LEU B CB    1 
ATOM   3062 C CG    . LEU B 1 166 ? -14.43400 27.26500  -18.24300 1.000 33.16407  ? 146  LEU B CG    1 
ATOM   3063 C CD1   . LEU B 1 166 ? -15.10100 27.86200  -19.45900 1.000 28.41589  ? 146  LEU B CD1   1 
ATOM   3064 C CD2   . LEU B 1 166 ? -13.87500 28.37000  -17.36300 1.000 28.57555  ? 146  LEU B CD2   1 
ATOM   3065 N N     . PHE B 1 167 ? -15.88100 23.57100  -15.50600 1.000 33.35807  ? 147  PHE B N     1 
ATOM   3066 C CA    . PHE B 1 167 ? -16.97800 22.86400  -14.85400 1.000 35.14984  ? 147  PHE B CA    1 
ATOM   3067 C C     . PHE B 1 167 ? -16.48000 21.91100  -13.77300 1.000 35.40859  ? 147  PHE B C     1 
ATOM   3068 O O     . PHE B 1 167 ? -17.15700 20.94500  -13.42400 1.000 37.37391  ? 147  PHE B O     1 
ATOM   3069 C CB    . PHE B 1 167 ? -17.82300 22.18600  -15.93800 1.000 35.52207  ? 147  PHE B CB    1 
ATOM   3070 C CG    . PHE B 1 167 ? -18.30900 23.18300  -16.96500 1.000 36.68766  ? 147  PHE B CG    1 
ATOM   3071 C CD1   . PHE B 1 167 ? -19.13000 24.25000  -16.57100 1.000 39.39638  ? 147  PHE B CD1   1 
ATOM   3072 C CD2   . PHE B 1 167 ? -17.85100 23.14600  -18.28200 1.000 37.80421  ? 147  PHE B CD2   1 
ATOM   3073 C CE1   . PHE B 1 167 ? -19.54500 25.22900  -17.48700 1.000 39.80805  ? 147  PHE B CE1   1 
ATOM   3074 C CE2   . PHE B 1 167 ? -18.26500 24.09500  -19.21100 1.000 36.37202  ? 147  PHE B CE2   1 
ATOM   3075 C CZ    . PHE B 1 167 ? -19.10200 25.14300  -18.82500 1.000 38.90906  ? 147  PHE B CZ    1 
ATOM   3076 N N     . SER B 1 168 ? -15.31800 22.19400  -13.20800 1.000 34.11804  ? 148  SER B N     1 
ATOM   3077 C CA    . SER B 1 168 ? -14.88800 21.51400  -12.00900 1.000 32.68949  ? 148  SER B CA    1 
ATOM   3078 C C     . SER B 1 168 ? -15.67900 22.01900  -10.79100 1.000 31.99866  ? 148  SER B C     1 
ATOM   3079 O O     . SER B 1 168 ? -16.21600 23.13300  -10.80300 1.000 30.61817  ? 148  SER B O     1 
ATOM   3080 C CB    . SER B 1 168 ? -13.41300 21.76200  -11.79300 1.000 35.59870  ? 148  SER B CB    1 
ATOM   3081 O OG    . SER B 1 168 ? -13.21900 23.08800  -11.34000 1.000 37.05263  ? 148  SER B OG    1 
ATOM   3082 N N     . PRO B 1 169 ? -15.76500 21.27000  -9.66300  1.000 32.63780  ? 149  PRO B N     1 
ATOM   3083 C CA    . PRO B 1 169 ? -16.54600 21.72900  -8.52900  1.000 28.54405  ? 149  PRO B CA    1 
ATOM   3084 C C     . PRO B 1 169 ? -16.02600 23.00500  -7.88900  1.000 28.98442  ? 149  PRO B C     1 
ATOM   3085 O O     . PRO B 1 169 ? -16.83500 23.81000  -7.42600  1.000 30.13718  ? 149  PRO B O     1 
ATOM   3086 C CB    . PRO B 1 169 ? -16.46400 20.53600  -7.56900  1.000 33.30377  ? 149  PRO B CB    1 
ATOM   3087 C CG    . PRO B 1 169 ? -16.25700 19.35600  -8.47100  1.000 41.98173  ? 149  PRO B CG    1 
ATOM   3088 C CD    . PRO B 1 169 ? -15.21800 19.92300  -9.40600  1.000 36.43528  ? 149  PRO B CD    1 
ATOM   3089 N N     . GLN B 1 170 ? -14.70400 23.17600  -7.87400  1.000 29.85364  ? 150  GLN B N     1 
ATOM   3090 C CA    . GLN B 1 170 ? -14.09800 24.39700  -7.27700  1.000 33.05457  ? 150  GLN B CA    1 
ATOM   3091 C C     . GLN B 1 170 ? -14.46300 25.63500  -8.11300  1.000 28.71258  ? 150  GLN B C     1 
ATOM   3092 O O     . GLN B 1 170 ? -14.67200 26.70200  -7.53400  1.000 28.17476  ? 150  GLN B O     1 
ATOM   3093 C CB    . GLN B 1 170 ? -12.58500 24.26300  -7.12800  1.000 35.66555  ? 150  GLN B CB    1 
ATOM   3094 C CG    . GLN B 1 170 ? -12.14700 23.01500  -6.37700  1.000 38.10069  ? 150  GLN B CG    1 
ATOM   3095 C CD    . GLN B 1 170 ? -11.60100 21.95400  -7.30200  1.000 44.18936  ? 150  GLN B CD    1 
ATOM   3096 O OE1   . GLN B 1 170 ? -12.29600 21.46200  -8.19700  1.000 47.57210  ? 150  GLN B OE1   1 
ATOM   3097 N NE2   . GLN B 1 170 ? -10.34200 21.60100  -7.09900  1.000 38.98799  ? 150  GLN B NE2   1 
ATOM   3098 N N     . VAL B 1 171 ? -14.49000 25.47300  -9.43200  1.000 29.90163  ? 151  VAL B N     1 
ATOM   3099 C CA    . VAL B 1 171 ? -14.77900 26.65400  -10.28300 1.000 26.31283  ? 151  VAL B CA    1 
ATOM   3100 C C     . VAL B 1 171 ? -16.24100 27.01500  -10.01600 1.000 24.85548  ? 151  VAL B C     1 
ATOM   3101 O O     . VAL B 1 171 ? -16.53100 28.16600  -9.75800  1.000 26.42816  ? 151  VAL B O     1 
ATOM   3102 C CB    . VAL B 1 171 ? -14.49900 26.47500  -11.78400 1.000 28.90422  ? 151  VAL B CB    1 
ATOM   3103 C CG1   . VAL B 1 171 ? -15.05300 27.63300  -12.60100 1.000 28.78559  ? 151  VAL B CG1   1 
ATOM   3104 C CG2   . VAL B 1 171 ? -13.00900 26.31600  -12.04700 1.000 30.23501  ? 151  VAL B CG2   1 
ATOM   3105 N N     . ILE B 1 172 ? -17.08600 25.99500  -10.00000 1.000 26.71212  ? 152  ILE B N     1 
ATOM   3106 C CA    . ILE B 1 172 ? -18.53000 26.26900  -9.75400  1.000 26.93540  ? 152  ILE B CA    1 
ATOM   3107 C C     . ILE B 1 172 ? -18.71100 26.90500  -8.36400  1.000 23.40743  ? 152  ILE B C     1 
ATOM   3108 O O     . ILE B 1 172 ? -19.37000 27.94000  -8.27700  1.000 26.69188  ? 152  ILE B O     1 
ATOM   3109 C CB    . ILE B 1 172 ? -19.35500 24.98400  -9.95300  1.000 28.14883  ? 152  ILE B CB    1 
ATOM   3110 C CG1   . ILE B 1 172 ? -19.38300 24.56200  -11.41800 1.000 29.23090  ? 152  ILE B CG1   1 
ATOM   3111 C CG2   . ILE B 1 172 ? -20.75900 25.12800  -9.37100  1.000 28.13005  ? 152  ILE B CG2   1 
ATOM   3112 C CD1   . ILE B 1 172 ? -19.51700 23.06700  -11.62500 1.000 31.74834  ? 152  ILE B CD1   1 
ATOM   3113 N N     . ARG B 1 173 ? -18.09300 26.32500  -7.33900  1.000 26.88831  ? 153  ARG B N     1 
ATOM   3114 C CA    . ARG B 1 173 ? -18.29500 26.81300  -5.94900  1.000 27.62110  ? 153  ARG B CA    1 
ATOM   3115 C C     . ARG B 1 173 ? -17.69800 28.21500  -5.75500  1.000 23.10511  ? 153  ARG B C     1 
ATOM   3116 O O     . ARG B 1 173 ? -18.39800 29.08900  -5.26400  1.000 25.32944  ? 153  ARG B O     1 
ATOM   3117 C CB    . ARG B 1 173 ? -17.67500 25.83000  -4.95500  1.000 32.23238  ? 153  ARG B CB    1 
ATOM   3118 C CG    . ARG B 1 173 ? -17.50200 26.33300  -3.53000  1.000 31.71642  ? 153  ARG B CG    1 
ATOM   3119 C CD    . ARG B 1 173 ? -18.80900 26.32800  -2.76600  1.000 32.08670  ? 153  ARG B CD    1 
ATOM   3120 N NE    . ARG B 1 173 ? -18.65000 26.42000  -1.31200  1.000 29.92337  ? 153  ARG B NE    1 
ATOM   3121 C CZ    . ARG B 1 173 ? -19.60600 26.17100  -0.42900  1.000 41.11585  ? 153  ARG B CZ    1 
ATOM   3122 N NH1   . ARG B 1 173 ? -20.83600 25.92500  -0.83800  1.000 34.27536  ? 153  ARG B NH1   1 
ATOM   3123 N NH2   . ARG B 1 173 ? -19.33500 26.17300  0.86200   1.000 35.08334  ? 153  ARG B NH2   1 
ATOM   3124 N N     . ASN B 1 174 ? -16.44200 28.39800  -6.13900  1.000 26.19494  ? 154  ASN B N     1 
ATOM   3125 C CA    . ASN B 1 174 ? -15.75600 29.69600  -5.88600  1.000 25.60828  ? 154  ASN B CA    1 
ATOM   3126 C C     . ASN B 1 174 ? -16.34000 30.79600  -6.78000  1.000 26.35365  ? 154  ASN B C     1 
ATOM   3127 O O     . ASN B 1 174 ? -16.18500 31.96600  -6.42200  1.000 26.77964  ? 154  ASN B O     1 
ATOM   3128 C CB    . ASN B 1 174 ? -14.24800 29.53600  -6.00000  1.000 26.05016  ? 154  ASN B CB    1 
ATOM   3129 C CG    . ASN B 1 174 ? -13.66300 28.70400  -4.88400  1.000 30.00204  ? 154  ASN B CG    1 
ATOM   3130 O OD1   . ASN B 1 174 ? -14.38700 27.96900  -4.21100  1.000 26.88639  ? 154  ASN B OD1   1 
ATOM   3131 N ND2   . ASN B 1 174 ? -12.36200 28.81400  -4.66800  1.000 26.27127  ? 154  ASN B ND2   1 
ATOM   3132 N N     . SER B 1 175 ? -16.95900 30.42300  -7.89900  1.000 24.42626  ? 155  SER B N     1 
ATOM   3133 C CA    . SER B 1 175 ? -17.62700 31.40900  -8.78400  1.000 24.14678  ? 155  SER B CA    1 
ATOM   3134 C C     . SER B 1 175 ? -19.01600 31.73600  -8.23300  1.000 25.87473  ? 155  SER B C     1 
ATOM   3135 O O     . SER B 1 175 ? -19.64900 32.64300  -8.75600  1.000 27.45213  ? 155  SER B O     1 
ATOM   3136 C CB    . SER B 1 175 ? -17.78100 30.87500  -10.18900 1.000 27.04888  ? 155  SER B CB    1 
ATOM   3137 O OG    . SER B 1 175 ? -18.69800 29.79800  -10.24900 1.000 28.98775  ? 155  SER B OG    1 
ATOM   3138 N N     . THR B 1 176 ? -19.46600 30.98500  -7.23400  1.000 29.77938  ? 156  THR B N     1 
ATOM   3139 C CA    . THR B 1 176 ? -20.84600 31.14200  -6.73300  1.000 28.58695  ? 156  THR B CA    1 
ATOM   3140 C C     . THR B 1 176 ? -21.81100 30.95300  -7.90400  1.000 28.71111  ? 156  THR B C     1 
ATOM   3141 O O     . THR B 1 176 ? -22.85300 31.60100  -7.90300  1.000 32.78364  ? 156  THR B O     1 
ATOM   3142 C CB    . THR B 1 176 ? -21.03700 32.45300  -5.95700  1.000 29.58666  ? 156  THR B CB    1 
ATOM   3143 O OG1   . THR B 1 176 ? -20.94400 33.58000  -6.82400  1.000 35.67907  ? 156  THR B OG1   1 
ATOM   3144 C CG2   . THR B 1 176 ? -20.04000 32.58600  -4.81700  1.000 31.98541  ? 156  THR B CG2   1 
ATOM   3145 N N     . GLY B 1 177 ? -21.47300 30.08100  -8.85300  1.000 25.31259  ? 157  GLY B N     1 
ATOM   3146 C CA    . GLY B 1 177 ? -22.33000 29.80300  -10.02300 1.000 29.76690  ? 157  GLY B CA    1 
ATOM   3147 C C     . GLY B 1 177 ? -22.21000 30.83500  -11.13600 1.000 31.65496  ? 157  GLY B C     1 
ATOM   3148 O O     . GLY B 1 177 ? -22.90500 30.69300  -12.14900 1.000 30.91375  ? 157  GLY B O     1 
ATOM   3149 N N     . ALA B 1 178 ? -21.34900 31.83200  -10.95500 1.000 28.04524  ? 158  ALA B N     1 
ATOM   3150 C CA    . ALA B 1 178 ? -21.20100 32.90300  -11.96400 1.000 30.31396  ? 158  ALA B CA    1 
ATOM   3151 C C     . ALA B 1 178 ? -20.65900 32.33200  -13.27500 1.000 27.05043  ? 158  ALA B C     1 
ATOM   3152 O O     . ALA B 1 178 ? -20.90900 32.90400  -14.33600 1.000 28.10864  ? 158  ALA B O     1 
ATOM   3153 C CB    . ALA B 1 178 ? -20.31000 33.98400  -11.42500 1.000 26.85593  ? 158  ALA B CB    1 
ATOM   3154 N N     . VAL B 1 179 ? -19.93800 31.22200  -13.18300 1.000 24.47779  ? 159  VAL B N     1 
ATOM   3155 C CA    . VAL B 1 179 ? -19.37300 30.63900  -14.38200 1.000 24.66813  ? 159  VAL B CA    1 
ATOM   3156 C C     . VAL B 1 179 ? -20.44200 30.30300  -15.43000 1.000 33.04921  ? 159  VAL B C     1 
ATOM   3157 O O     . VAL B 1 179 ? -20.13000 30.25300  -16.62300 1.000 31.21036  ? 159  VAL B O     1 
ATOM   3158 C CB    . VAL B 1 179 ? -18.52300 29.40400  -14.01100 1.000 29.53971  ? 159  VAL B CB    1 
ATOM   3159 C CG1   . VAL B 1 179 ? -19.39800 28.28400  -13.44800 1.000 28.25720  ? 159  VAL B CG1   1 
ATOM   3160 C CG2   . VAL B 1 179 ? -17.73800 28.93800  -15.18700 1.000 28.69951  ? 159  VAL B CG2   1 
ATOM   3161 N N     . PHE B 1 180 ? -21.68700 30.06900  -15.03900 1.000 30.04688  ? 160  PHE B N     1 
ATOM   3162 C CA    . PHE B 1 180 ? -22.67600 29.56000  -16.03700 1.000 28.60570  ? 160  PHE B CA    1 
ATOM   3163 C C     . PHE B 1 180 ? -23.07200 30.61600  -17.07000 1.000 30.19544  ? 160  PHE B C     1 
ATOM   3164 O O     . PHE B 1 180 ? -23.15100 30.28900  -18.25500 1.000 30.78940  ? 160  PHE B O     1 
ATOM   3165 C CB    . PHE B 1 180 ? -23.87200 28.95700  -15.29800 1.000 27.96504  ? 160  PHE B CB    1 
ATOM   3166 C CG    . PHE B 1 180 ? -23.49800 27.81200  -14.37100 1.000 27.09247  ? 160  PHE B CG    1 
ATOM   3167 C CD1   . PHE B 1 180 ? -22.77600 26.72400  -14.84000 1.000 28.70387  ? 160  PHE B CD1   1 
ATOM   3168 C CD2   . PHE B 1 180 ? -23.85800 27.83300  -13.03100 1.000 27.57288  ? 160  PHE B CD2   1 
ATOM   3169 C CE1   . PHE B 1 180 ? -22.43500 25.68600  -13.99400 1.000 27.85047  ? 160  PHE B CE1   1 
ATOM   3170 C CE2   . PHE B 1 180 ? -23.51200 26.79200  -12.18900 1.000 28.90549  ? 160  PHE B CE2   1 
ATOM   3171 C CZ    . PHE B 1 180 ? -22.80200 25.72500  -12.67300 1.000 30.33324  ? 160  PHE B CZ    1 
ATOM   3172 N N     . ALA B 1 181 ? -23.32100 31.83800  -16.62500 1.000 29.53738  ? 161  ALA B N     1 
ATOM   3173 C CA    . ALA B 1 181 ? -23.78800 32.90000  -17.54600 1.000 35.44190  ? 161  ALA B CA    1 
ATOM   3174 C C     . ALA B 1 181 ? -22.62400 33.70600  -18.13600 1.000 36.57891  ? 161  ALA B C     1 
ATOM   3175 O O     . ALA B 1 181 ? -22.82700 34.40000  -19.13500 1.000 32.02583  ? 161  ALA B O     1 
ATOM   3176 C CB    . ALA B 1 181 ? -24.71700 33.81000  -16.80000 1.000 32.77956  ? 161  ALA B CB    1 
ATOM   3177 N N     . LEU B 1 182 ? -21.45500 33.62600  -17.51700 1.000 29.83689  ? 162  LEU B N     1 
ATOM   3178 C CA    . LEU B 1 182 ? -20.32000 34.46700  -17.96100 1.000 30.81876  ? 162  LEU B CA    1 
ATOM   3179 C C     . LEU B 1 182 ? -19.80700 34.03900  -19.33600 1.000 29.20454  ? 162  LEU B C     1 
ATOM   3180 O O     . LEU B 1 182 ? -19.61400 32.85200  -19.55800 1.000 27.41854  ? 162  LEU B O     1 
ATOM   3181 C CB    . LEU B 1 182 ? -19.22300 34.40600  -16.90400 1.000 30.06888  ? 162  LEU B CB    1 
ATOM   3182 C CG    . LEU B 1 182 ? -18.01100 35.31800  -17.10500 1.000 28.87554  ? 162  LEU B CG    1 
ATOM   3183 C CD1   . LEU B 1 182 ? -18.36000 36.76300  -16.81600 1.000 28.34648  ? 162  LEU B CD1   1 
ATOM   3184 C CD2   . LEU B 1 182 ? -16.91500 34.84600  -16.18000 1.000 23.93956  ? 162  LEU B CD2   1 
ATOM   3185 N N     . PRO B 1 183 ? -19.60300 35.00400  -20.25200 1.000 31.29776  ? 163  PRO B N     1 
ATOM   3186 C CA    . PRO B 1 183 ? -19.01200 34.69100  -21.54200 1.000 31.66680  ? 163  PRO B CA    1 
ATOM   3187 C C     . PRO B 1 183 ? -17.52500 34.39500  -21.36900 1.000 28.51365  ? 163  PRO B C     1 
ATOM   3188 O O     . PRO B 1 183 ? -16.69400 35.27300  -21.60100 1.000 28.43242  ? 163  PRO B O     1 
ATOM   3189 C CB    . PRO B 1 183 ? -19.30200 35.93300  -22.37400 1.000 32.27148  ? 163  PRO B CB    1 
ATOM   3190 C CG    . PRO B 1 183 ? -19.51200 37.03500  -21.36200 1.000 36.90517  ? 163  PRO B CG    1 
ATOM   3191 C CD    . PRO B 1 183 ? -19.97600 36.38900  -20.08200 1.000 28.77335  ? 163  PRO B CD    1 
ATOM   3192 N N     . VAL B 1 184 ? -17.21600 33.17100  -20.95500 1.000 26.30977  ? 164  VAL B N     1 
ATOM   3193 C CA    . VAL B 1 184 ? -15.80200 32.74700  -20.75300 1.000 27.39942  ? 164  VAL B CA    1 
ATOM   3194 C C     . VAL B 1 184 ? -15.50300 31.64800  -21.77700 1.000 32.30164  ? 164  VAL B C     1 
ATOM   3195 O O     . VAL B 1 184 ? -16.32300 30.73400  -21.91000 1.000 30.58260  ? 164  VAL B O     1 
ATOM   3196 C CB    . VAL B 1 184 ? -15.49400 32.29300  -19.31300 1.000 30.60940  ? 164  VAL B CB    1 
ATOM   3197 C CG1   . VAL B 1 184 ? -16.54900 31.35100  -18.75500 1.000 35.17572  ? 164  VAL B CG1   1 
ATOM   3198 C CG2   . VAL B 1 184 ? -14.09300 31.71500  -19.17200 1.000 26.09052  ? 164  VAL B CG2   1 
ATOM   3199 N N     . TYR B 1 185 ? -14.37400 31.74800  -22.46200 1.000 27.01950  ? 165  TYR B N     1 
ATOM   3200 C CA    . TYR B 1 185 ? -14.09500 30.80100  -23.56600 1.000 27.81687  ? 165  TYR B CA    1 
ATOM   3201 C C     . TYR B 1 185 ? -12.68400 30.28200  -23.51500 1.000 26.49143  ? 165  TYR B C     1 
ATOM   3202 O O     . TYR B 1 185 ? -11.74200 31.07200  -23.55400 1.000 28.78002  ? 165  TYR B O     1 
ATOM   3203 C CB    . TYR B 1 185 ? -14.30300 31.53800  -24.88800 1.000 28.78202  ? 165  TYR B CB    1 
ATOM   3204 C CG    . TYR B 1 185 ? -15.73300 31.96300  -25.18000 1.000 34.58777  ? 165  TYR B CG    1 
ATOM   3205 C CD1   . TYR B 1 185 ? -16.23800 33.16500  -24.70300 1.000 30.82504  ? 165  TYR B CD1   1 
ATOM   3206 C CD2   . TYR B 1 185 ? -16.57500 31.15700  -25.93100 1.000 35.50874  ? 165  TYR B CD2   1 
ATOM   3207 C CE1   . TYR B 1 185 ? -17.54100 33.55000  -24.95800 1.000 36.44953  ? 165  TYR B CE1   1 
ATOM   3208 C CE2   . TYR B 1 185 ? -17.87900 31.53300  -26.19500 1.000 37.77065  ? 165  TYR B CE2   1 
ATOM   3209 C CZ    . TYR B 1 185 ? -18.36400 32.73100  -25.70600 1.000 36.35486  ? 165  TYR B CZ    1 
ATOM   3210 O OH    . TYR B 1 185 ? -19.64600 33.10300  -25.96900 1.000 40.84836  ? 165  TYR B OH    1 
ATOM   3211 N N     . PRO B 1 186 ? -12.48000 28.95600  -23.41000 1.000 28.23362  ? 166  PRO B N     1 
ATOM   3212 C CA    . PRO B 1 186 ? -11.12800 28.39500  -23.51900 1.000 27.61518  ? 166  PRO B CA    1 
ATOM   3213 C C     . PRO B 1 186 ? -10.72300 28.34500  -24.98700 1.000 33.78064  ? 166  PRO B C     1 
ATOM   3214 O O     . PRO B 1 186 ? -11.49600 27.89000  -25.83900 1.000 29.84580  ? 166  PRO B O     1 
ATOM   3215 C CB    . PRO B 1 186 ? -11.26500 26.98800  -22.92000 1.000 30.65880  ? 166  PRO B CB    1 
ATOM   3216 C CG    . PRO B 1 186 ? -12.70900 26.90700  -22.38300 1.000 32.25939  ? 166  PRO B CG    1 
ATOM   3217 C CD    . PRO B 1 186 ? -13.49200 27.91700  -23.14400 1.000 29.46036  ? 166  PRO B CD    1 
ATOM   3218 N N     . VAL B 1 187 ? -9.54100  28.88100  -25.29200 1.000 29.97300  ? 167  VAL B N     1 
ATOM   3219 C CA    . VAL B 1 187 ? -9.12500  29.07700  -26.68600 1.000 35.07352  ? 167  VAL B CA    1 
ATOM   3220 C C     . VAL B 1 187 ? -7.61200  28.97600  -26.74100 1.000 32.97583  ? 167  VAL B C     1 
ATOM   3221 O O     . VAL B 1 187 ? -6.90900  29.29600  -25.77200 1.000 31.85011  ? 167  VAL B O     1 
ATOM   3222 C CB    . VAL B 1 187 ? -9.58600  30.43300  -27.30400 1.000 33.52290  ? 167  VAL B CB    1 
ATOM   3223 C CG1   . VAL B 1 187 ? -11.11900 30.55600  -27.39400 1.000 37.80362  ? 167  VAL B CG1   1 
ATOM   3224 C CG2   . VAL B 1 187 ? -9.02700  31.60100  -26.54200 1.000 34.02884  ? 167  VAL B CG2   1 
ATOM   3225 N N     . ALA B 1 188 ? -7.11300  28.51900  -27.89100 1.000 36.93930  ? 168  ALA B N     1 
ATOM   3226 C CA    . ALA B 1 188 ? -5.68400  28.52100  -28.15900 1.000 38.49774  ? 168  ALA B CA    1 
ATOM   3227 C C     . ALA B 1 188 ? -5.14200  29.94600  -28.11900 1.000 32.88309  ? 168  ALA B C     1 
ATOM   3228 O O     . ALA B 1 188 ? -5.86100  30.91000  -28.40300 1.000 32.34291  ? 168  ALA B O     1 
ATOM   3229 C CB    . ALA B 1 188 ? -5.40500  27.91500  -29.55000 1.000 37.04183  ? 168  ALA B CB    1 
ATOM   3230 N N     . GLU B 1 189 ? -3.84700  30.05700  -27.81200 1.000 35.59837  ? 169  GLU B N     1 
ATOM   3231 C CA    . GLU B 1 189 ? -3.16600  31.35000  -27.75700 1.000 37.39583  ? 169  GLU B CA    1 
ATOM   3232 C C     . GLU B 1 189 ? -3.28100  32.14300  -29.05900 1.000 39.20072  ? 169  GLU B C     1 
ATOM   3233 O O     . GLU B 1 189 ? -3.59600  33.34500  -29.03700 1.000 36.27036  ? 169  GLU B O     1 
ATOM   3234 C CB    . GLU B 1 189 ? -1.70700  31.13100  -27.38800 1.000 39.29332  ? 169  GLU B CB    1 
ATOM   3235 C CG    . GLU B 1 189 ? -0.95000  32.43900  -27.16900 1.000 45.87938  ? 169  GLU B CG    1 
ATOM   3236 C CD    . GLU B 1 189 ? 0.45400   32.23900  -26.63200 1.000 52.89105  ? 169  GLU B CD    1 
ATOM   3237 O OE1   . GLU B 1 189 ? 0.64400   31.38500  -25.72500 1.000 59.90864  ? 169  GLU B OE1   1 
ATOM   3238 O OE2   . GLU B 1 189 ? 1.36500   32.95600  -27.11600 1.000 54.92428  ? 169  GLU B OE2   1 
ATOM   3239 N N     . GLU B 1 190 ? -3.07500  31.50000  -30.20800 1.000 34.78862  ? 170  GLU B N     1 
ATOM   3240 C CA    . GLU B 1 190 ? -3.14200  32.21100  -31.50900 1.000 35.18837  ? 170  GLU B CA    1 
ATOM   3241 C C     . GLU B 1 190 ? -4.57600  32.68800  -31.76800 1.000 33.84178  ? 170  GLU B C     1 
ATOM   3242 O O     . GLU B 1 190 ? -4.75400  33.79100  -32.30200 1.000 35.67820  ? 170  GLU B O     1 
ATOM   3243 C CB    . GLU B 1 190 ? -2.68100  31.32600  -32.66700 1.000 37.63507  ? 170  GLU B CB    1 
ATOM   3244 C CG    . GLU B 1 190 ? -3.02800  31.87600  -34.04800 1.000 35.49019  ? 170  GLU B CG    1 
ATOM   3245 C CD    . GLU B 1 190 ? -2.27500  33.12200  -34.48200 1.000 40.66675  ? 170  GLU B CD    1 
ATOM   3246 O OE1   . GLU B 1 190 ? -1.15800  33.34200  -33.98200 1.000 40.77758  ? 170  GLU B OE1   1 
ATOM   3247 O OE2   . GLU B 1 190 ? -2.80100  33.86800  -35.33000 1.000 37.62058  ? 170  GLU B OE2   1 
ATOM   3248 N N     . GLU B 1 191 ? -5.55600  31.87600  -31.38900 1.000 33.77317  ? 171  GLU B N     1 
ATOM   3249 C CA    . GLU B 1 191 ? -6.97500  32.26100  -31.56600 1.000 33.04544  ? 171  GLU B CA    1 
ATOM   3250 C C     . GLU B 1 191 ? -7.28000  33.50400  -30.71900 1.000 27.66038  ? 171  GLU B C     1 
ATOM   3251 O O     . GLU B 1 191 ? -8.03200  34.36400  -31.17100 1.000 31.12881  ? 171  GLU B O     1 
ATOM   3252 C CB    . GLU B 1 191 ? -7.84000  31.06500  -31.17600 1.000 35.76510  ? 171  GLU B CB    1 
ATOM   3253 C CG    . GLU B 1 191 ? -9.31900  31.25400  -31.49200 1.000 42.28351  ? 171  GLU B CG    1 
ATOM   3254 C CD    . GLU B 1 191 ? -10.19400 30.07100  -31.12300 1.000 48.30003  ? 171  GLU B CD    1 
ATOM   3255 O OE1   . GLU B 1 191 ? -9.65500  29.02000  -30.72300 1.000 46.60270  ? 171  GLU B OE1   1 
ATOM   3256 O OE2   . GLU B 1 191 ? -11.42400 30.21300  -31.23500 1.000 46.16751  ? 171  GLU B OE2   1 
ATOM   3257 N N     . ALA B 1 192 ? -6.71700  33.56500  -29.52100 1.000 32.08728  ? 172  ALA B N     1 
ATOM   3258 C CA    . ALA B 1 192 ? -6.96400  34.71700  -28.62700 1.000 29.80700  ? 172  ALA B CA    1 
ATOM   3259 C C     . ALA B 1 192 ? -6.31700  35.96300  -29.23400 1.000 27.59548  ? 172  ALA B C     1 
ATOM   3260 O O     . ALA B 1 192 ? -6.99700  36.97600  -29.41400 1.000 26.57831  ? 172  ALA B O     1 
ATOM   3261 C CB    . ALA B 1 192 ? -6.42400  34.39700  -27.26500 1.000 30.55731  ? 172  ALA B CB    1 
ATOM   3262 N N     . ALA B 1 193 ? -5.04200  35.84400  -29.58800 1.000 29.97285  ? 173  ALA B N     1 
ATOM   3263 C CA    . ALA B 1 193 ? -4.31600  36.96900  -30.22400 1.000 31.17444  ? 173  ALA B CA    1 
ATOM   3264 C C     . ALA B 1 193 ? -5.08800  37.47500  -31.44000 1.000 30.59551  ? 173  ALA B C     1 
ATOM   3265 O O     . ALA B 1 193 ? -5.26400  38.68200  -31.57700 1.000 30.68813  ? 173  ALA B O     1 
ATOM   3266 C CB    . ALA B 1 193 ? -2.94000  36.49800  -30.60800 1.000 36.31148  ? 173  ALA B CB    1 
ATOM   3267 N N     . ARG B 1 194 ? -5.54500  36.55800  -32.28600 1.000 32.82469  ? 174  ARG B N     1 
ATOM   3268 C CA    . ARG B 1 194 ? -6.23600  36.95400  -33.53200 1.000 31.87537  ? 174  ARG B CA    1 
ATOM   3269 C C     . ARG B 1 194 ? -7.53100  37.68000  -33.19100 1.000 30.62352  ? 174  ARG B C     1 
ATOM   3270 O O     . ARG B 1 194 ? -7.79700  38.71700  -33.79000 1.000 31.71661  ? 174  ARG B O     1 
ATOM   3271 C CB    . ARG B 1 194 ? -6.52200  35.71100  -34.37900 1.000 35.63407  ? 174  ARG B CB    1 
ATOM   3272 C CG    . ARG B 1 194 ? -6.07800  35.70800  -35.83000 1.000 43.97521  ? 174  ARG B CG    1 
ATOM   3273 C CD    . ARG B 1 194 ? -6.28300  34.30800  -36.37100 1.000 45.34699  ? 174  ARG B CD    1 
ATOM   3274 N NE    . ARG B 1 194 ? -5.05900  33.74400  -36.94600 1.000 50.52932  ? 174  ARG B NE    1 
ATOM   3275 C CZ    . ARG B 1 194 ? -4.97200  33.30900  -38.19400 1.000 52.23315  ? 174  ARG B CZ    1 
ATOM   3276 N NH1   . ARG B 1 194 ? -6.07100  33.02000  -38.86400 1.000 46.39489  ? 174  ARG B NH1   1 
ATOM   3277 N NH2   . ARG B 1 194 ? -3.79400  33.17600  -38.77000 1.000 45.76489  ? 174  ARG B NH2   1 
ATOM   3278 N N     . PHE B 1 195 ? -8.30200  37.12500  -32.26000 1.000 33.14588  ? 175  PHE B N     1 
ATOM   3279 C CA    . PHE B 1 195 ? -9.61300  37.73200  -31.91600 1.000 29.83808  ? 175  PHE B CA    1 
ATOM   3280 C C     . PHE B 1 195 ? -9.35900  39.15300  -31.47100 1.000 21.93024  ? 175  PHE B C     1 
ATOM   3281 O O     . PHE B 1 195 ? -10.03200 40.07000  -31.92800 1.000 30.47423  ? 175  PHE B O     1 
ATOM   3282 C CB    . PHE B 1 195 ? -10.34400 36.92600  -30.83700 1.000 27.23627  ? 175  PHE B CB    1 
ATOM   3283 C CG    . PHE B 1 195 ? -11.69200 37.48100  -30.41100 1.000 30.11164  ? 175  PHE B CG    1 
ATOM   3284 C CD1   . PHE B 1 195 ? -11.78800 38.38000  -29.35800 1.000 33.25888  ? 175  PHE B CD1   1 
ATOM   3285 C CD2   . PHE B 1 195 ? -12.85700 37.09800  -31.06000 1.000 28.59960  ? 175  PHE B CD2   1 
ATOM   3286 C CE1   . PHE B 1 195 ? -13.01200 38.89200  -28.98100 1.000 30.77353  ? 175  PHE B CE1   1 
ATOM   3287 C CE2   . PHE B 1 195 ? -14.08100 37.60700  -30.66900 1.000 32.23100  ? 175  PHE B CE2   1 
ATOM   3288 C CZ    . PHE B 1 195 ? -14.15500 38.50100  -29.63200 1.000 35.32576  ? 175  PHE B CZ    1 
ATOM   3289 N N     . LEU B 1 196 ? -8.39200  39.31900  -30.58200 1.000 26.18114  ? 176  LEU B N     1 
ATOM   3290 C CA    . LEU B 1 196 ? -8.10300  40.66200  -30.02000 1.000 28.33182  ? 176  LEU B CA    1 
ATOM   3291 C C     . LEU B 1 196 ? -7.65900  41.61500  -31.13200 1.000 25.70927  ? 176  LEU B C     1 
ATOM   3292 O O     . LEU B 1 196 ? -8.15900  42.73100  -31.17200 1.000 30.73300  ? 176  LEU B O     1 
ATOM   3293 C CB    . LEU B 1 196 ? -7.03400  40.50200  -28.94500 1.000 27.99961  ? 176  LEU B CB    1 
ATOM   3294 C CG    . LEU B 1 196 ? -7.43600  39.64400  -27.74300 1.000 24.20546  ? 176  LEU B CG    1 
ATOM   3295 C CD1   . LEU B 1 196 ? -6.24400  39.28000  -26.88300 1.000 24.99094  ? 176  LEU B CD1   1 
ATOM   3296 C CD2   . LEU B 1 196 ? -8.52000  40.31300  -26.92500 1.000 24.79473  ? 176  LEU B CD2   1 
ATOM   3297 N N     . GLU B 1 197 ? -6.75700  41.15300  -31.99200 1.000 32.72380  ? 177  GLU B N     1 
ATOM   3298 C CA    . GLU B 1 197 ? -6.26600  41.97500  -33.12700 1.000 31.04580  ? 177  GLU B CA    1 
ATOM   3299 C C     . GLU B 1 197 ? -7.43400  42.40300  -34.01500 1.000 26.69539  ? 177  GLU B C     1 
ATOM   3300 O O     . GLU B 1 197 ? -7.50800  43.57000  -34.36700 1.000 31.35024  ? 177  GLU B O     1 
ATOM   3301 C CB    . GLU B 1 197 ? -5.33500  41.14100  -33.99900 1.000 33.52461  ? 177  GLU B CB    1 
ATOM   3302 C CG    . GLU B 1 197 ? -3.95400  40.91700  -33.40200 1.000 40.91538  ? 177  GLU B CG    1 
ATOM   3303 C CD    . GLU B 1 197 ? -3.13600  39.97900  -34.26400 1.000 40.47907  ? 177  GLU B CD    1 
ATOM   3304 O OE1   . GLU B 1 197 ? -3.71700  39.35100  -35.16700 1.000 39.12769  ? 177  GLU B OE1   1 
ATOM   3305 O OE2   . GLU B 1 197 ? -1.92000  39.87900  -34.02500 1.000 47.88510  ? 177  GLU B OE2   1 
ATOM   3306 N N     . GLU B 1 198 ? -8.30300  41.46500  -34.35500 1.000 29.17520  ? 178  GLU B N     1 
ATOM   3307 C CA    . GLU B 1 198 ? -9.40900  41.76300  -35.29900 1.000 28.01649  ? 178  GLU B CA    1 
ATOM   3308 C C     . GLU B 1 198 ? -10.39100 42.75600  -34.67300 1.000 29.88486  ? 178  GLU B C     1 
ATOM   3309 O O     . GLU B 1 198 ? -11.15900 43.36900  -35.42100 1.000 28.29723  ? 178  GLU B O     1 
ATOM   3310 C CB    . GLU B 1 198 ? -10.01200 40.43000  -35.72500 1.000 30.19906  ? 178  GLU B CB    1 
ATOM   3311 C CG    . GLU B 1 198 ? -9.03000  39.57800  -36.52100 1.000 32.13736  ? 178  GLU B CG    1 
ATOM   3312 C CD    . GLU B 1 198 ? -9.59900  38.25100  -36.97600 1.000 41.32406  ? 178  GLU B CD    1 
ATOM   3313 O OE1   . GLU B 1 198 ? -10.82600 38.08500  -36.88200 1.000 50.63471  ? 178  GLU B OE1   1 
ATOM   3314 O OE2   . GLU B 1 198 ? -8.82100  37.39300  -37.42500 1.000 46.06185  ? 178  GLU B OE2   1 
ATOM   3315 N N     . GLN B 1 199 ? -10.36900 42.87000  -33.34600 1.000 28.87096  ? 179  GLN B N     1 
ATOM   3316 C CA    . GLN B 1 199 ? -11.24200 43.84400  -32.64900 1.000 31.13421  ? 179  GLN B CA    1 
ATOM   3317 C C     . GLN B 1 199 ? -10.49000 45.17200  -32.50100 1.000 29.25733  ? 179  GLN B C     1 
ATOM   3318 O O     . GLN B 1 199 ? -11.13100 46.15800  -32.14000 1.000 30.95286  ? 179  GLN B O     1 
ATOM   3319 C CB    . GLN B 1 199 ? -11.64400 43.30200  -31.27700 1.000 30.16660  ? 179  GLN B CB    1 
ATOM   3320 C CG    . GLN B 1 199 ? -12.63600 42.14500  -31.32200 1.000 31.40546  ? 179  GLN B CG    1 
ATOM   3321 C CD    . GLN B 1 199 ? -14.00400 42.53200  -31.84100 1.000 32.24011  ? 179  GLN B CD    1 
ATOM   3322 O OE1   . GLN B 1 199 ? -14.49200 43.64600  -31.62500 1.000 41.19777  ? 179  GLN B OE1   1 
ATOM   3323 N NE2   . GLN B 1 199 ? -14.64300 41.60300  -32.53100 1.000 34.93482  ? 179  GLN B NE2   1 
ATOM   3324 N N     . ASN B 1 200 ? -9.18800  45.17700  -32.79100 1.000 29.32374  ? 180  ASN B N     1 
ATOM   3325 C CA    . ASN B 1 200 ? -8.34200  46.39000  -32.59000 1.000 29.65280  ? 180  ASN B CA    1 
ATOM   3326 C C     . ASN B 1 200 ? -8.48900  46.81700  -31.13200 1.000 30.95516  ? 180  ASN B C     1 
ATOM   3327 O O     . ASN B 1 200 ? -8.60800  48.01800  -30.87100 1.000 32.56099  ? 180  ASN B O     1 
ATOM   3328 C CB    . ASN B 1 200 ? -8.61300  47.50500  -33.59600 1.000 31.54019  ? 180  ASN B CB    1 
ATOM   3329 C CG    . ASN B 1 200 ? -7.49700  48.52300  -33.61900 1.000 32.99429  ? 180  ASN B CG    1 
ATOM   3330 O OD1   . ASN B 1 200 ? -6.34500  48.18700  -33.33800 1.000 34.76178  ? 180  ASN B OD1   1 
ATOM   3331 N ND2   . ASN B 1 200 ? -7.81500  49.76900  -33.92800 1.000 35.27388  ? 180  ASN B ND2   1 
ATOM   3332 N N     . LEU B 1 201 ? -8.46300  45.83500  -30.23400 1.000 30.96073  ? 181  LEU B N     1 
ATOM   3333 C CA    . LEU B 1 201 ? -8.61600  46.08800  -28.78500 1.000 33.34659  ? 181  LEU B CA    1 
ATOM   3334 C C     . LEU B 1 201 ? -7.26400  46.39500  -28.14200 1.000 29.36046  ? 181  LEU B C     1 
ATOM   3335 O O     . LEU B 1 201 ? -6.36500  45.56200  -28.23000 1.000 33.08468  ? 181  LEU B O     1 
ATOM   3336 C CB    . LEU B 1 201 ? -9.22700  44.83600  -28.16100 1.000 32.97579  ? 181  LEU B CB    1 
ATOM   3337 C CG    . LEU B 1 201 ? -10.69200 44.93400  -27.73400 1.000 42.25560  ? 181  LEU B CG    1 
ATOM   3338 C CD1   . LEU B 1 201 ? -11.01800 43.77900  -26.81600 1.000 38.48533  ? 181  LEU B CD1   1 
ATOM   3339 C CD2   . LEU B 1 201 ? -10.95900 46.25100  -27.04000 1.000 37.63870  ? 181  LEU B CD2   1 
ATOM   3340 N N     . PRO B 1 202 ? -7.11400  47.55600  -27.48400 1.000 33.18035  ? 182  PRO B N     1 
ATOM   3341 C CA    . PRO B 1 202 ? -5.89500  47.85100  -26.74800 1.000 35.54987  ? 182  PRO B CA    1 
ATOM   3342 C C     . PRO B 1 202 ? -5.63600  46.77400  -25.70900 1.000 32.11256  ? 182  PRO B C     1 
ATOM   3343 O O     . PRO B 1 202 ? -6.55400  46.41400  -24.96600 1.000 28.42034  ? 182  PRO B O     1 
ATOM   3344 C CB    . PRO B 1 202 ? -6.21800  49.19000  -26.11600 1.000 31.97929  ? 182  PRO B CB    1 
ATOM   3345 C CG    . PRO B 1 202 ? -7.25300  49.79100  -27.02300 1.000 39.70816  ? 182  PRO B CG    1 
ATOM   3346 C CD    . PRO B 1 202 ? -8.10100  48.60700  -27.42600 1.000 40.86620  ? 182  PRO B CD    1 
ATOM   3347 N N     . LEU B 1 203 ? -4.40900  46.26600  -25.68100 1.000 29.05698  ? 183  LEU B N     1 
ATOM   3348 C CA    . LEU B 1 203 ? -4.03100  45.24000  -24.69300 1.000 30.34851  ? 183  LEU B CA    1 
ATOM   3349 C C     . LEU B 1 203 ? -3.31000  45.93800  -23.53600 1.000 31.45767  ? 183  LEU B C     1 
ATOM   3350 O O     . LEU B 1 203 ? -2.42600  46.76100  -23.80400 1.000 30.74018  ? 183  LEU B O     1 
ATOM   3351 C CB    . LEU B 1 203 ? -3.14300  44.17300  -25.31800 1.000 33.92633  ? 183  LEU B CB    1 
ATOM   3352 C CG    . LEU B 1 203 ? -3.66400  43.50000  -26.58800 1.000 37.11970  ? 183  LEU B CG    1 
ATOM   3353 C CD1   . LEU B 1 203 ? -2.69100  42.41000  -26.99300 1.000 38.80694  ? 183  LEU B CD1   1 
ATOM   3354 C CD2   . LEU B 1 203 ? -5.03800  42.92400  -26.33500 1.000 34.22868  ? 183  LEU B CD2   1 
ATOM   3355 N N     . VAL B 1 204 ? -3.69600  45.60200  -22.31100 1.000 26.93286  ? 184  VAL B N     1 
ATOM   3356 C CA    . VAL B 1 204 ? -3.08400  46.24600  -21.11500 1.000 25.66568  ? 184  VAL B CA    1 
ATOM   3357 C C     . VAL B 1 204 ? -2.54900  45.12500  -20.21900 1.000 25.22776  ? 184  VAL B C     1 
ATOM   3358 O O     . VAL B 1 204 ? -3.34600  44.38800  -19.65100 1.000 28.44224  ? 184  VAL B O     1 
ATOM   3359 C CB    . VAL B 1 204 ? -4.03400  47.20000  -20.37000 1.000 26.48943  ? 184  VAL B CB    1 
ATOM   3360 C CG1   . VAL B 1 204 ? -3.40700  47.75700  -19.10200 1.000 24.86392  ? 184  VAL B CG1   1 
ATOM   3361 C CG2   . VAL B 1 204 ? -4.55600  48.31300  -21.26800 1.000 25.66010  ? 184  VAL B CG2   1 
ATOM   3362 N N     . ALA B 1 205 ? -1.23200  45.00900  -20.15100 1.000 24.75793  ? 185  ALA B N     1 
ATOM   3363 C CA    . ALA B 1 205 ? -0.61900  43.91800  -19.37700 1.000 26.93599  ? 185  ALA B CA    1 
ATOM   3364 C C     . ALA B 1 205 ? -0.49700  44.31300  -17.91100 1.000 33.99311  ? 185  ALA B C     1 
ATOM   3365 O O     . ALA B 1 205 ? 0.13600   45.31500  -17.59400 1.000 29.44439  ? 185  ALA B O     1 
ATOM   3366 C CB    . ALA B 1 205 ? 0.72500   43.58100  -19.93200 1.000 28.11776  ? 185  ALA B CB    1 
ATOM   3367 N N     . ALA B 1 206 ? -1.10000  43.51000  -17.05100 1.000 29.12489  ? 186  ALA B N     1 
ATOM   3368 C CA    . ALA B 1 206 ? -0.99900  43.77800  -15.61200 1.000 30.61364  ? 186  ALA B CA    1 
ATOM   3369 C C     . ALA B 1 206 ? 0.21400   43.05200  -15.08500 1.000 32.28626  ? 186  ALA B C     1 
ATOM   3370 O O     . ALA B 1 206 ? 0.26200   41.81900  -15.12700 1.000 32.84567  ? 186  ALA B O     1 
ATOM   3371 C CB    . ALA B 1 206 ? -2.23700  43.31100  -14.84700 1.000 28.25479  ? 186  ALA B CB    1 
ATOM   3372 N N     . THR B 1 207 ? 1.19100   43.79000  -14.59000 1.000 29.94888  ? 187  THR B N     1 
ATOM   3373 C CA    . THR B 1 207 ? 2.39200   43.14200  -14.03600 1.000 37.33860  ? 187  THR B CA    1 
ATOM   3374 C C     . THR B 1 207 ? 2.95500   43.99700  -12.93300 1.000 35.36768  ? 187  THR B C     1 
ATOM   3375 O O     . THR B 1 207 ? 2.92100   45.21900  -13.05700 1.000 33.67980  ? 187  THR B O     1 
ATOM   3376 C CB    . THR B 1 207 ? 3.42000   42.86700  -15.13800 1.000 36.98434  ? 187  THR B CB    1 
ATOM   3377 O OG1   . THR B 1 207 ? 4.50200   42.20600  -14.49800 1.000 51.52244  ? 187  THR B OG1   1 
ATOM   3378 C CG2   . THR B 1 207 ? 3.88500   44.12500  -15.84900 1.000 37.03843  ? 187  THR B CG2   1 
ATOM   3379 N N     . PRO B 1 208 ? 3.40600   43.39200  -11.82300 1.000 36.52628  ? 188  PRO B N     1 
ATOM   3380 C CA    . PRO B 1 208 ? 3.89000   44.18800  -10.68100 1.000 40.37258  ? 188  PRO B CA    1 
ATOM   3381 C C     . PRO B 1 208 ? 4.97400   45.19100  -11.02700 1.000 41.53115  ? 188  PRO B C     1 
ATOM   3382 O O     . PRO B 1 208 ? 5.08500   46.20200  -10.31900 1.000 42.10911  ? 188  PRO B O     1 
ATOM   3383 C CB    . PRO B 1 208 ? 4.40100   43.12200  -9.69600  1.000 37.70388  ? 188  PRO B CB    1 
ATOM   3384 C CG    . PRO B 1 208 ? 3.52000   41.93800  -9.95600  1.000 44.91419  ? 188  PRO B CG    1 
ATOM   3385 C CD    . PRO B 1 208 ? 3.31600   41.95300  -11.48400 1.000 38.28953  ? 188  PRO B CD    1 
ATOM   3386 N N     . GLU B 1 209 ? 5.71900   44.98700  -12.11500 1.000 38.19276  ? 189  GLU B N     1 
ATOM   3387 C CA    . GLU B 1 209 ? 6.74700   45.90800  -12.56200 1.000 39.21832  ? 189  GLU B CA    1 
ATOM   3388 C C     . GLU B 1 209 ? 6.29600   46.75900  -13.73700 1.000 39.22719  ? 189  GLU B C     1 
ATOM   3389 O O     . GLU B 1 209 ? 7.11400   47.45300  -14.32900 1.000 36.99038  ? 189  GLU B O     1 
ATOM   3390 C CB    . GLU B 1 209 ? 8.03100   45.13800  -12.90100 1.000 45.60789  ? 189  GLU B CB    1 
ATOM   3391 C CG    . GLU B 1 209 ? 8.07300   44.43300  -14.26500 1.000 53.17877  ? 189  GLU B CG    1 
ATOM   3392 C CD    . GLU B 1 209 ? 7.32200   43.08200  -14.33200 1.000 54.13771  ? 189  GLU B CD    1 
ATOM   3393 O OE1   . GLU B 1 209 ? 6.73600   42.60900  -13.30700 1.000 51.67247  ? 189  GLU B OE1   1 
ATOM   3394 O OE2   . GLU B 1 209 ? 7.31300   42.49500  -15.44300 1.000 52.57654  ? 189  GLU B OE2   1 
ATOM   3395 N N     . GLY B 1 210 ? 4.99900   46.80200  -14.01100 1.000 34.24872  ? 190  GLY B N     1 
ATOM   3396 C CA    . GLY B 1 210 ? 4.47800   47.68500  -15.06500 1.000 33.23359  ? 190  GLY B CA    1 
ATOM   3397 C C     . GLY B 1 210 ? 4.98300   49.10900  -14.94700 1.000 34.95194  ? 190  GLY B C     1 
ATOM   3398 O O     . GLY B 1 210 ? 5.12300   49.58900  -13.82300 1.000 32.39437  ? 190  GLY B O     1 
ATOM   3399 N N     . GLU B 1 211 ? 5.17500   49.78100  -16.08200 1.000 31.45476  ? 191  GLU B N     1 
ATOM   3400 C CA    . GLU B 1 211 ? 5.77800   51.13600  -16.08800 1.000 34.08727  ? 191  GLU B CA    1 
ATOM   3401 C C     . GLU B 1 211 ? 4.79400   52.20000  -15.59800 1.000 33.40357  ? 191  GLU B C     1 
ATOM   3402 O O     . GLU B 1 211 ? 5.23800   53.30500  -15.29400 1.000 27.83579  ? 191  GLU B O     1 
ATOM   3403 C CB    . GLU B 1 211 ? 6.23200   51.50000  -17.50100 1.000 34.33140  ? 191  GLU B CB    1 
ATOM   3404 C CG    . GLU B 1 211 ? 5.10200   51.66500  -18.51100 1.000 32.30479  ? 191  GLU B CG    1 
ATOM   3405 C CD    . GLU B 1 211 ? 4.93800   50.47900  -19.44100 1.000 29.51832  ? 191  GLU B CD    1 
ATOM   3406 O OE1   . GLU B 1 211 ? 5.59400   49.45100  -19.19900 1.000 30.87960  ? 191  GLU B OE1   1 
ATOM   3407 O OE2   . GLU B 1 211 ? 4.15300   50.58700  -20.39900 1.000 34.84912  ? 191  GLU B OE2   1 
ATOM   3408 N N     . ARG B 1 212 ? 3.45300   51.93300  -15.66500 1.000 27.60762  ? 192  ARG B N     1 
ATOM   3409 C CA    . ARG B 1 212 ? 2.47900   52.91400  -15.21900 1.000 29.91379  ? 192  ARG B CA    1 
ATOM   3410 C C     . ARG B 1 212 ? 1.65600   52.32300  -14.08500 1.000 27.88651  ? 192  ARG B C     1 
ATOM   3411 O O     . ARG B 1 212 ? 1.47800   51.10700  -14.00600 1.000 23.96926  ? 192  ARG B O     1 
ATOM   3412 C CB    . ARG B 1 212 ? 1.49500   53.34900  -16.33100 1.000 30.04583  ? 192  ARG B CB    1 
ATOM   3413 C CG    . ARG B 1 212 ? 2.12000   53.91300  -17.60000 1.000 37.84298  ? 192  ARG B CG    1 
ATOM   3414 C CD    . ARG B 1 212 ? 2.78300   55.23500  -17.33900 1.000 34.72060  ? 192  ARG B CD    1 
ATOM   3415 N NE    . ARG B 1 212 ? 1.84200   56.33600  -17.30600 1.000 46.80336  ? 192  ARG B NE    1 
ATOM   3416 C CZ    . ARG B 1 212 ? 2.19700   57.62700  -17.41300 1.000 47.07469  ? 192  ARG B CZ    1 
ATOM   3417 N NH1   . ARG B 1 212 ? 3.46600   57.98000  -17.56500 1.000 40.25607  ? 192  ARG B NH1   1 
ATOM   3418 N NH2   . ARG B 1 212 ? 1.28100   58.57300  -17.37200 1.000 47.19265  ? 192  ARG B NH2   1 
ATOM   3419 N N     . LEU B 1 213 ? 1.13300   53.20100  -13.22100 1.000 25.51946  ? 193  LEU B N     1 
ATOM   3420 C CA    . LEU B 1 213 ? 0.10300   52.79200  -12.26900 1.000 26.84561  ? 193  LEU B CA    1 
ATOM   3421 C C     . LEU B 1 213 ? -1.15700  52.40300  -13.03200 1.000 25.17335  ? 193  LEU B C     1 
ATOM   3422 O O     . LEU B 1 213 ? -1.45300  52.96700  -14.08700 1.000 26.30739  ? 193  LEU B O     1 
ATOM   3423 C CB    . LEU B 1 213 ? -0.22300  53.93700  -11.31000 1.000 23.52321  ? 193  LEU B CB    1 
ATOM   3424 C CG    . LEU B 1 213 ? 0.91700   54.45800  -10.41500 1.000 22.26375  ? 193  LEU B CG    1 
ATOM   3425 C CD1   . LEU B 1 213 ? 0.46000   55.70300  -9.63100  1.000 21.90099  ? 193  LEU B CD1   1 
ATOM   3426 C CD2   . LEU B 1 213 ? 1.47200   53.38800  -9.47100  1.000 25.47004  ? 193  LEU B CD2   1 
ATOM   3427 N N     . TYR B 1 214 ? -1.91100  51.41500  -12.51500 1.000 24.50735  ? 194  TYR B N     1 
ATOM   3428 C CA    . TYR B 1 214 ? -3.07300  50.97000  -13.29400 1.000 19.67831  ? 194  TYR B CA    1 
ATOM   3429 C C     . TYR B 1 214 ? -4.13200  52.05100  -13.39700 1.000 23.30360  ? 194  TYR B C     1 
ATOM   3430 O O     . TYR B 1 214 ? -4.85600  52.11500  -14.39900 1.000 23.53707  ? 194  TYR B O     1 
ATOM   3431 C CB    . TYR B 1 214 ? -3.65500  49.65300  -12.72900 1.000 21.54936  ? 194  TYR B CB    1 
ATOM   3432 C CG    . TYR B 1 214 ? -4.45800  49.74700  -11.44800 1.000 20.86606  ? 194  TYR B CG    1 
ATOM   3433 C CD1   . TYR B 1 214 ? -3.85700  50.10600  -10.23400 1.000 19.21073  ? 194  TYR B CD1   1 
ATOM   3434 C CD2   . TYR B 1 214 ? -5.79500  49.38700  -11.43500 1.000 22.25542  ? 194  TYR B CD2   1 
ATOM   3435 C CE1   . TYR B 1 214 ? -4.59300  50.13400  -9.04500  1.000 18.57172  ? 194  TYR B CE1   1 
ATOM   3436 C CE2   . TYR B 1 214 ? -6.56200  49.46200  -10.27700 1.000 18.90207  ? 194  TYR B CE2   1 
ATOM   3437 C CZ    . TYR B 1 214 ? -5.97000  49.81800  -9.07400  1.000 20.91689  ? 194  TYR B CZ    1 
ATOM   3438 O OH    . TYR B 1 214 ? -6.76500  49.82600  -7.91800  1.000 21.86881  ? 194  TYR B OH    1 
ATOM   3439 N N     . TRP B 1 215 ? -4.17100  52.99300  -12.46600 1.000 21.13889  ? 195  TRP B N     1 
ATOM   3440 C CA    . TRP B 1 215 ? -5.12300  54.12800  -12.57700 1.000 19.73370  ? 195  TRP B CA    1 
ATOM   3441 C C     . TRP B 1 215 ? -4.77400  55.07200  -13.74400 1.000 22.26776  ? 195  TRP B C     1 
ATOM   3442 O O     . TRP B 1 215 ? -5.61200  55.90000  -14.08400 1.000 22.48186  ? 195  TRP B O     1 
ATOM   3443 C CB    . TRP B 1 215 ? -5.15900  54.91600  -11.26400 1.000 24.26041  ? 195  TRP B CB    1 
ATOM   3444 C CG    . TRP B 1 215 ? -5.48900  54.13400  -10.02500 1.000 23.28538  ? 195  TRP B CG    1 
ATOM   3445 C CD1   . TRP B 1 215 ? -6.64000  53.46300  -9.74300  1.000 24.18208  ? 195  TRP B CD1   1 
ATOM   3446 C CD2   . TRP B 1 215 ? -4.65100  54.00300  -8.86000  1.000 24.88377  ? 195  TRP B CD2   1 
ATOM   3447 N NE1   . TRP B 1 215 ? -6.57000  52.90800  -8.49500  1.000 22.31401  ? 195  TRP B NE1   1 
ATOM   3448 C CE2   . TRP B 1 215 ? -5.36600  53.22400  -7.92800  1.000 23.68164  ? 195  TRP B CE2   1 
ATOM   3449 C CE3   . TRP B 1 215 ? -3.37500  54.46300  -8.52100  1.000 22.63793  ? 195  TRP B CE3   1 
ATOM   3450 C CZ2   . TRP B 1 215 ? -4.84200  52.89400  -6.68200  1.000 23.94944  ? 195  TRP B CZ2   1 
ATOM   3451 C CZ3   . TRP B 1 215 ? -2.86100  54.13900  -7.28700  1.000 25.33707  ? 195  TRP B CZ3   1 
ATOM   3452 C CH2   . TRP B 1 215 ? -3.58800  53.37000  -6.38100  1.000 24.57140  ? 195  TRP B CH2   1 
ATOM   3453 N N     . GLU B 1 216 ? -3.58000  54.94100  -14.31700 1.000 22.78936  ? 196  GLU B N     1 
ATOM   3454 C CA    . GLU B 1 216 ? -3.14700  55.88400  -15.36000 1.000 26.67433  ? 196  GLU B CA    1 
ATOM   3455 C C     . GLU B 1 216 ? -3.52400  55.42500  -16.75600 1.000 31.80089  ? 196  GLU B C     1 
ATOM   3456 O O     . GLU B 1 216 ? -3.58000  56.25500  -17.67200 1.000 32.03480  ? 196  GLU B O     1 
ATOM   3457 C CB    . GLU B 1 216 ? -1.62400  56.10200  -15.26900 1.000 30.71965  ? 196  GLU B CB    1 
ATOM   3458 C CG    . GLU B 1 216 ? -1.24600  56.85200  -13.95500 1.000 26.35233  ? 196  GLU B CG    1 
ATOM   3459 C CD    . GLU B 1 216 ? 0.24200   56.85400  -13.56200 1.000 31.06327  ? 196  GLU B CD    1 
ATOM   3460 O OE1   . GLU B 1 216 ? 0.65900   57.74500  -12.74800 1.000 32.34062  ? 196  GLU B OE1   1 
ATOM   3461 O OE2   . GLU B 1 216 ? 1.00400   55.98000  -13.96900 1.000 27.09586  ? 196  GLU B OE2   1 
ATOM   3462 N N     . GLY B 1 217 ? -3.83000  54.14400  -16.93600 1.000 24.20950  ? 197  GLY B N     1 
ATOM   3463 C CA    . GLY B 1 217 ? -4.36500  53.70500  -18.21300 1.000 28.97026  ? 197  GLY B CA    1 
ATOM   3464 C C     . GLY B 1 217 ? -5.69500  54.36800  -18.49800 1.000 30.27035  ? 197  GLY B C     1 
ATOM   3465 O O     . GLY B 1 217 ? -6.43400  54.75300  -17.58300 1.000 29.25325  ? 197  GLY B O     1 
ATOM   3466 N N     . ASP B 1 218 ? -6.01700  54.49500  -19.78900 1.000 25.87393  ? 198  ASP B N     1 
ATOM   3467 C CA    . ASP B 1 218 ? -7.34600  55.02000  -20.20000 1.000 29.27441  ? 198  ASP B CA    1 
ATOM   3468 C C     . ASP B 1 218 ? -8.19100  53.83900  -20.66900 1.000 31.01405  ? 198  ASP B C     1 
ATOM   3469 O O     . ASP B 1 218 ? -7.85500  53.26500  -21.70800 1.000 29.88162  ? 198  ASP B O     1 
ATOM   3470 C CB    . ASP B 1 218 ? -7.26300  56.05900  -21.30200 1.000 32.03091  ? 198  ASP B CB    1 
ATOM   3471 C CG    . ASP B 1 218 ? -8.51400  56.89100  -21.49300 1.000 35.78756  ? 198  ASP B CG    1 
ATOM   3472 O OD1   . ASP B 1 218 ? -9.61600  56.34700  -21.31500 1.000 36.75079  ? 198  ASP B OD1   1 
ATOM   3473 O OD2   . ASP B 1 218 ? -8.36500  58.07700  -21.82100 1.000 43.51723  ? 198  ASP B OD2   1 
ATOM   3474 N N     . TYR B 1 219 ? -9.24200  53.51300  -19.93100 1.000 27.78000  ? 199  TYR B N     1 
ATOM   3475 C CA    . TYR B 1 219 ? -10.04100 52.30600  -20.24800 1.000 27.81296  ? 199  TYR B CA    1 
ATOM   3476 C C     . TYR B 1 219 ? -11.46700 52.69400  -20.65300 1.000 30.64063  ? 199  TYR B C     1 
ATOM   3477 O O     . TYR B 1 219 ? -12.34900 51.84300  -20.62900 1.000 37.04800  ? 199  TYR B O     1 
ATOM   3478 C CB    . TYR B 1 219 ? -9.98800  51.40700  -19.01000 1.000 25.87148  ? 199  TYR B CB    1 
ATOM   3479 C CG    . TYR B 1 219 ? -8.62900  51.19800  -18.36300 1.000 23.44975  ? 199  TYR B CG    1 
ATOM   3480 C CD1   . TYR B 1 219 ? -7.54900  50.73400  -19.09800 1.000 22.59540  ? 199  TYR B CD1   1 
ATOM   3481 C CD2   . TYR B 1 219 ? -8.43800  51.44200  -17.01200 1.000 21.64559  ? 199  TYR B CD2   1 
ATOM   3482 C CE1   . TYR B 1 219 ? -6.31400  50.53400  -18.51200 1.000 23.01380  ? 199  TYR B CE1   1 
ATOM   3483 C CE2   . TYR B 1 219 ? -7.20700  51.24300  -16.41400 1.000 22.56033  ? 199  TYR B CE2   1 
ATOM   3484 C CZ    . TYR B 1 219 ? -6.14100  50.78700  -17.16600 1.000 24.08749  ? 199  TYR B CZ    1 
ATOM   3485 O OH    . TYR B 1 219 ? -4.91900  50.58700  -16.60300 1.000 20.80027  ? 199  TYR B OH    1 
ATOM   3486 N N     . ARG B 1 220 ? -11.67600 53.95200  -21.02300 1.000 28.41170  ? 200  ARG B N     1 
ATOM   3487 C CA    . ARG B 1 220 ? -13.03600 54.43300  -21.37300 1.000 33.15342  ? 200  ARG B CA    1 
ATOM   3488 C C     . ARG B 1 220 ? -13.43200 53.93500  -22.77300 1.000 32.09712  ? 200  ARG B C     1 
ATOM   3489 O O     . ARG B 1 220 ? -14.63000 53.83700  -23.04000 1.000 38.17072  ? 200  ARG B O     1 
ATOM   3490 C CB    . ARG B 1 220 ? -13.04100 55.95900  -21.26100 1.000 40.08888  ? 200  ARG B CB    1 
ATOM   3491 C CG    . ARG B 1 220 ? -12.65900 56.48400  -19.88500 1.000 38.15166  ? 200  ARG B CG    1 
ATOM   3492 C CD    . ARG B 1 220 ? -12.51100 57.99300  -19.86500 1.000 38.34699  ? 200  ARG B CD    1 
ATOM   3493 N NE    . ARG B 1 220 ? -11.17900 58.45500  -20.26300 1.000 39.57375  ? 200  ARG B NE    1 
ATOM   3494 C CZ    . ARG B 1 220 ? -10.73900 59.68700  -20.06300 1.000 41.43801  ? 200  ARG B CZ    1 
ATOM   3495 N NH1   . ARG B 1 220 ? -11.47400 60.54400  -19.38200 1.000 47.62211  ? 200  ARG B NH1   1 
ATOM   3496 N NH2   . ARG B 1 220 ? -9.56700  60.06000  -20.53600 1.000 34.93464  ? 200  ARG B NH2   1 
ATOM   3497 N N     . GLY B 1 221 ? -12.44800 53.62400  -23.60500 1.000 29.91426  ? 201  GLY B N     1 
ATOM   3498 C CA    . GLY B 1 221 ? -12.73600 53.18800  -24.97700 1.000 40.34540  ? 201  GLY B CA    1 
ATOM   3499 C C     . GLY B 1 221 ? -12.55800 51.70500  -25.18300 1.000 43.70378  ? 201  GLY B C     1 
ATOM   3500 O O     . GLY B 1 221 ? -12.44200 51.28200  -26.33700 1.000 51.43102  ? 201  GLY B O     1 
ATOM   3501 N N     . GLY B 1 222 ? -12.51900 50.91900  -24.12300 1.000 39.00528  ? 202  GLY B N     1 
ATOM   3502 C CA    . GLY B 1 222 ? -12.41500 49.48400  -24.41900 1.000 43.02888  ? 202  GLY B CA    1 
ATOM   3503 C C     . GLY B 1 222 ? -11.04700 48.96200  -24.12100 1.000 42.14949  ? 202  GLY B C     1 
ATOM   3504 O O     . GLY B 1 222 ? -10.07000 49.56800  -24.57500 1.000 47.28872  ? 202  GLY B O     1 
ATOM   3505 N N     . VAL B 1 223 ? -10.99000 47.86000  -23.39500 1.000 36.30574  ? 203  VAL B N     1 
ATOM   3506 C CA    . VAL B 1 223 ? -9.68000  47.34900  -22.95000 1.000 31.58875  ? 203  VAL B CA    1 
ATOM   3507 C C     . VAL B 1 223 ? -9.69900  45.82500  -22.84100 1.000 26.85347  ? 203  VAL B C     1 
ATOM   3508 O O     . VAL B 1 223 ? -10.77000 45.26100  -22.58000 1.000 25.97069  ? 203  VAL B O     1 
ATOM   3509 C CB    . VAL B 1 223 ? -9.38300  47.98100  -21.57700 1.000 31.60709  ? 203  VAL B CB    1 
ATOM   3510 C CG1   . VAL B 1 223 ? -10.55100 47.83400  -20.61500 1.000 33.83045  ? 203  VAL B CG1   1 
ATOM   3511 C CG2   . VAL B 1 223 ? -8.09100  47.47000  -20.95800 1.000 31.46526  ? 203  VAL B CG2   1 
ATOM   3512 N N     . ALA B 1 224 ? -8.55400  45.21400  -23.09500 1.000 25.77382  ? 204  ALA B N     1 
ATOM   3513 C CA    . ALA B 1 224 ? -8.39900  43.78300  -22.81600 1.000 25.66052  ? 204  ALA B CA    1 
ATOM   3514 C C     . ALA B 1 224 ? -7.27800  43.69700  -21.78500 1.000 26.61984  ? 204  ALA B C     1 
ATOM   3515 O O     . ALA B 1 224 ? -6.13900  43.96500  -22.16200 1.000 24.72879  ? 204  ALA B O     1 
ATOM   3516 C CB    . ALA B 1 224 ? -8.02600  43.04000  -24.05200 1.000 25.50678  ? 204  ALA B CB    1 
ATOM   3517 N N     . PHE B 1 225 ? -7.60700  43.41500  -20.52600 1.000 23.17539  ? 205  PHE B N     1 
ATOM   3518 C CA    . PHE B 1 225 ? -6.52200  43.20600  -19.56900 1.000 23.49899  ? 205  PHE B CA    1 
ATOM   3519 C C     . PHE B 1 225 ? -5.90000  41.82300  -19.73800 1.000 23.97590  ? 205  PHE B C     1 
ATOM   3520 O O     . PHE B 1 225 ? -6.59800  40.81000  -19.87100 1.000 25.63593  ? 205  PHE B O     1 
ATOM   3521 C CB    . PHE B 1 225 ? -7.01800  43.38500  -18.12400 1.000 23.24942  ? 205  PHE B CB    1 
ATOM   3522 C CG    . PHE B 1 225 ? -7.40300  44.81700  -17.77900 1.000 21.15772  ? 205  PHE B CG    1 
ATOM   3523 C CD1   . PHE B 1 225 ? -6.43800  45.77200  -17.49300 1.000 20.73712  ? 205  PHE B CD1   1 
ATOM   3524 C CD2   . PHE B 1 225 ? -8.72600  45.19700  -17.72600 1.000 24.55898  ? 205  PHE B CD2   1 
ATOM   3525 C CE1   . PHE B 1 225 ? -6.82700  47.08100  -17.18000 1.000 21.89471  ? 205  PHE B CE1   1 
ATOM   3526 C CE2   . PHE B 1 225 ? -9.08900  46.47200  -17.39100 1.000 24.92942  ? 205  PHE B CE2   1 
ATOM   3527 C CZ    . PHE B 1 225 ? -8.14500  47.40700  -17.12100 1.000 20.53854  ? 205  PHE B CZ    1 
ATOM   3528 N N     . LEU B 1 226 ? -4.57900  41.77400  -19.68100 1.000 24.54807  ? 206  LEU B N     1 
ATOM   3529 C CA    . LEU B 1 226 ? -3.83700  40.52800  -19.72000 1.000 25.70144  ? 206  LEU B CA    1 
ATOM   3530 C C     . LEU B 1 226 ? -3.33200  40.22100  -18.31600 1.000 31.72825  ? 206  LEU B C     1 
ATOM   3531 O O     . LEU B 1 226 ? -2.71600  41.07600  -17.66400 1.000 31.42820  ? 206  LEU B O     1 
ATOM   3532 C CB    . LEU B 1 226 ? -2.65700  40.62900  -20.70500 1.000 29.46554  ? 206  LEU B CB    1 
ATOM   3533 C CG    . LEU B 1 226 ? -2.77600  41.25300  -22.10100 1.000 32.58965  ? 206  LEU B CG    1 
ATOM   3534 C CD1   . LEU B 1 226 ? -1.44000  41.14600  -22.89100 1.000 31.63207  ? 206  LEU B CD1   1 
ATOM   3535 C CD2   . LEU B 1 226 ? -3.92300  40.67400  -22.92600 1.000 30.25765  ? 206  LEU B CD2   1 
ATOM   3536 N N     . LEU B 1 227 ? -3.65300  39.02900  -17.83400 1.000 28.30292  ? 207  LEU B N     1 
ATOM   3537 C CA    . LEU B 1 227 ? -3.32100  38.64200  -16.44600 1.000 28.88585  ? 207  LEU B CA    1 
ATOM   3538 C C     . LEU B 1 227 ? -2.72100  37.23600  -16.42000 1.000 37.20495  ? 207  LEU B C     1 
ATOM   3539 O O     . LEU B 1 227 ? -3.27100  36.34100  -17.07400 1.000 34.30354  ? 207  LEU B O     1 
ATOM   3540 C CB    . LEU B 1 227 ? -4.62100  38.69400  -15.65200 1.000 33.91747  ? 207  LEU B CB    1 
ATOM   3541 C CG    . LEU B 1 227 ? -4.51300  38.64900  -14.12800 1.000 38.75429  ? 207  LEU B CG    1 
ATOM   3542 C CD1   . LEU B 1 227 ? -3.78500  39.88200  -13.67300 1.000 42.67742  ? 207  LEU B CD1   1 
ATOM   3543 C CD2   . LEU B 1 227 ? -5.91500  38.65300  -13.56500 1.000 37.01094  ? 207  LEU B CD2   1 
ATOM   3544 N N     . GLY B 1 228 ? -1.64400  37.06300  -15.65600 1.000 37.64901  ? 208  GLY B N     1 
ATOM   3545 C CA    . GLY B 1 228 ? -0.98800  35.75400  -15.55500 1.000 41.39963  ? 208  GLY B CA    1 
ATOM   3546 C C     . GLY B 1 228 ? -1.43600  34.96000  -14.35200 1.000 40.67472  ? 208  GLY B C     1 
ATOM   3547 O O     . GLY B 1 228 ? -2.18400  35.49500  -13.54000 1.000 42.77313  ? 208  GLY B O     1 
ATOM   3548 N N     . ALA B 1 229 ? -0.96900  33.72000  -14.24200 1.000 51.36761  ? 209  ALA B N     1 
ATOM   3549 C CA    . ALA B 1 229 ? -1.36100  32.82200  -13.12900 1.000 47.46554  ? 209  ALA B CA    1 
ATOM   3550 C C     . ALA B 1 229 ? -0.61400  33.17200  -11.84200 1.000 54.69518  ? 209  ALA B C     1 
ATOM   3551 O O     . ALA B 1 229 ? 0.53000   33.65300  -11.93400 1.000 56.68684  ? 209  ALA B O     1 
ATOM   3552 C CB    . ALA B 1 229 ? -1.09200  31.40800  -13.54000 1.000 49.18271  ? 209  ALA B CB    1 
ATOM   3553 N N     . GLU B 1 230 ? -1.22600  32.91500  -10.68000 1.000 50.52791  ? 210  GLU B N     1 
ATOM   3554 C CA    . GLU B 1 230 ? -0.61500  33.29100  -9.37500  1.000 55.06920  ? 210  GLU B CA    1 
ATOM   3555 C C     . GLU B 1 230 ? 0.80300   32.70100  -9.25900  1.000 62.14439  ? 210  GLU B C     1 
ATOM   3556 O O     . GLU B 1 230 ? 1.72900   33.45900  -8.91500  1.000 65.08403  ? 210  GLU B O     1 
ATOM   3557 C CB    . GLU B 1 230 ? -1.48900  32.88100  -8.18800  1.000 52.23090  ? 210  GLU B CB    1 
ATOM   3558 C CG    . GLU B 1 230 ? -2.19500  34.04800  -7.50100  1.000 47.80138  ? 210  GLU B CG    1 
ATOM   3559 C CD    . GLU B 1 230 ? -3.06400  33.67100  -6.30900  1.000 49.86464  ? 210  GLU B CD    1 
ATOM   3560 O OE1   . GLU B 1 230 ? -2.60000  32.85500  -5.49200  1.000 55.42122  ? 210  GLU B OE1   1 
ATOM   3561 O OE2   . GLU B 1 230 ? -4.19400  34.17800  -6.18300  1.000 41.42799  ? 210  GLU B OE2   1 
ATOM   3562 N N     . ASP B 1 231 ? 0.95200   31.40200  -9.50900  1.000 54.75792  ? 211  ASP B N     1 
ATOM   3563 N N     . LYS B 1 232 ? 3.70800   32.22700  -11.12500 1.000 62.75764  ? 212  LYS B N     1 
ATOM   3564 C CA    . LYS B 1 232 ? 3.24000   32.32100  -12.53100 1.000 61.61065  ? 212  LYS B CA    1 
ATOM   3565 C C     . LYS B 1 232 ? 3.81100   33.57800  -13.21000 1.000 66.30996  ? 212  LYS B C     1 
ATOM   3566 O O     . LYS B 1 232 ? 5.04700   33.74500  -13.18000 1.000 69.28617  ? 212  LYS B O     1 
ATOM   3567 N N     . GLY B 1 233 ? 2.96000   34.39800  -13.83900 1.000 63.42865  ? 213  GLY B N     1 
ATOM   3568 C CA    . GLY B 1 233 ? 3.43100   35.59600  -14.57400 1.000 58.03551  ? 213  GLY B CA    1 
ATOM   3569 C C     . GLY B 1 233 ? 3.04800   35.58300  -16.04800 1.000 57.57334  ? 213  GLY B C     1 
ATOM   3570 O O     . GLY B 1 233 ? 2.68000   34.51200  -16.54600 1.000 62.24828  ? 213  GLY B O     1 
ATOM   3571 N N     . LEU B 1 234 ? 3.16400   36.71800  -16.74500 1.000 56.01538  ? 214  LEU B N     1 
ATOM   3572 C CA    . LEU B 1 234 ? 2.73000   36.78400  -18.14000 1.000 49.61631  ? 214  LEU B CA    1 
ATOM   3573 C C     . LEU B 1 234 ? 3.87000   36.43500  -19.09100 1.000 55.32981  ? 214  LEU B C     1 
ATOM   3574 O O     . LEU B 1 234 ? 5.03700   36.70700  -18.79500 1.000 61.01538  ? 214  LEU B O     1 
ATOM   3575 C CB    . LEU B 1 234 ? 2.22900   38.18200  -18.48300 1.000 50.04298  ? 214  LEU B CB    1 
ATOM   3576 C CG    . LEU B 1 234 ? 0.89200   38.68200  -17.95000 1.000 48.75794  ? 214  LEU B CG    1 
ATOM   3577 C CD1   . LEU B 1 234 ? 0.84000   40.20000  -18.07400 1.000 37.14572  ? 214  LEU B CD1   1 
ATOM   3578 C CD2   . LEU B 1 234 ? -0.26200  38.04600  -18.73800 1.000 40.73661  ? 214  LEU B CD2   1 
ATOM   3579 N N     . PRO B 1 235 ? 3.57100   35.87100  -20.26300 1.000 56.13294  ? 215  PRO B N     1 
ATOM   3580 C CA    . PRO B 1 235 ? 4.63400   35.60500  -21.23300 1.000 50.99526  ? 215  PRO B CA    1 
ATOM   3581 C C     . PRO B 1 235 ? 5.15300   36.90300  -21.83200 1.000 55.80213  ? 215  PRO B C     1 
ATOM   3582 O O     . PRO B 1 235 ? 4.40300   37.86900  -22.02800 1.000 54.32426  ? 215  PRO B O     1 
ATOM   3583 C CB    . PRO B 1 235 ? 3.94700   34.73400  -22.29600 1.000 50.30593  ? 215  PRO B CB    1 
ATOM   3584 C CG    . PRO B 1 235 ? 2.57700   34.40200  -21.73900 1.000 50.14735  ? 215  PRO B CG    1 
ATOM   3585 C CD    . PRO B 1 235 ? 2.24900   35.50700  -20.80000 1.000 51.58025  ? 215  PRO B CD    1 
ATOM   3586 N N     . GLU B 1 236 ? 6.45400   36.89900  -22.15500 1.000 52.05012  ? 216  GLU B N     1 
ATOM   3587 C CA    . GLU B 1 236 ? 7.14800   38.13400  -22.51500 1.000 52.78366  ? 216  GLU B CA    1 
ATOM   3588 C C     . GLU B 1 236 ? 6.56200   38.77500  -23.76800 1.000 51.86882  ? 216  GLU B C     1 
ATOM   3589 O O     . GLU B 1 236 ? 6.38900   40.00100  -23.82600 1.000 51.04865  ? 216  GLU B O     1 
ATOM   3590 C CB    . GLU B 1 236 ? 8.63900   37.85400  -22.71400 1.000 57.65561  ? 216  GLU B CB    1 
ATOM   3591 C CG    . GLU B 1 236 ? 9.52100   39.06900  -22.51200 1.000 61.57610  ? 216  GLU B CG    1 
ATOM   3592 C CD    . GLU B 1 236 ? 9.56800   39.50500  -21.05200 1.000 65.43255  ? 216  GLU B CD    1 
ATOM   3593 O OE1   . GLU B 1 236 ? 9.73400   40.71700  -20.80400 1.000 67.76787  ? 216  GLU B OE1   1 
ATOM   3594 O OE2   . GLU B 1 236 ? 9.43400   38.63700  -20.15400 1.000 66.46321  ? 216  GLU B OE2   1 
ATOM   3595 N N     . ALA B 1 237 ? 6.27200   37.96700  -24.79200 1.000 53.87153  ? 217  ALA B N     1 
ATOM   3596 C CA    . ALA B 1 237 ? 5.77600   38.52100  -26.04800 1.000 51.30088  ? 217  ALA B CA    1 
ATOM   3597 C C     . ALA B 1 237 ? 4.43400   39.20300  -25.84600 1.000 49.30602  ? 217  ALA B C     1 
ATOM   3598 O O     . ALA B 1 237 ? 4.14000   40.22300  -26.49300 1.000 45.10887  ? 217  ALA B O     1 
ATOM   3599 C CB    . ALA B 1 237 ? 5.67100   37.41800  -27.10900 1.000 48.16656  ? 217  ALA B CB    1 
ATOM   3600 N N     . TRP B 1 238 ? 3.61200   38.67400  -24.93900 1.000 44.76957  ? 218  TRP B N     1 
ATOM   3601 C CA    . TRP B 1 238 ? 2.35100   39.34800  -24.64500 1.000 42.89020  ? 218  TRP B CA    1 
ATOM   3602 C C     . TRP B 1 238 ? 2.60300   40.69400  -23.95000 1.000 42.10577  ? 218  TRP B C     1 
ATOM   3603 O O     . TRP B 1 238 ? 1.96700   41.70100  -24.29200 1.000 39.84352  ? 218  TRP B O     1 
ATOM   3604 C CB    . TRP B 1 238 ? 1.43500   38.43400  -23.80700 1.000 41.87440  ? 218  TRP B CB    1 
ATOM   3605 C CG    . TRP B 1 238 ? 0.68200   37.33000  -24.59400 1.000 43.01188  ? 218  TRP B CG    1 
ATOM   3606 C CD1   . TRP B 1 238 ? 1.13700   36.06100  -24.86700 1.000 45.60488  ? 218  TRP B CD1   1 
ATOM   3607 C CD2   . TRP B 1 238 ? -0.65400  37.40000  -25.16000 1.000 42.09762  ? 218  TRP B CD2   1 
ATOM   3608 N NE1   . TRP B 1 238 ? 0.18200   35.35300  -25.56600 1.000 44.64891  ? 218  TRP B NE1   1 
ATOM   3609 C CE2   . TRP B 1 238 ? -0.92100  36.14400  -25.76100 1.000 42.04486  ? 218  TRP B CE2   1 
ATOM   3610 C CE3   . TRP B 1 238 ? -1.63900  38.39400  -25.21100 1.000 36.17347  ? 218  TRP B CE3   1 
ATOM   3611 C CZ2   . TRP B 1 238 ? -2.12800  35.86000  -26.40800 1.000 37.77900  ? 218  TRP B CZ2   1 
ATOM   3612 C CZ3   . TRP B 1 238 ? -2.83800  38.11200  -25.84900 1.000 39.93089  ? 218  TRP B CZ3   1 
ATOM   3613 C CH2   . TRP B 1 238 ? -3.07200  36.85000  -26.45000 1.000 37.21225  ? 218  TRP B CH2   1 
ATOM   3614 N N     . LYS B 1 239 ? 3.51600   40.73800  -22.98800 1.000 45.74555  ? 219  LYS B N     1 
ATOM   3615 C CA    . LYS B 1 239 ? 3.83400   42.02800  -22.31500 1.000 44.57169  ? 219  LYS B CA    1 
ATOM   3616 C C     . LYS B 1 239 ? 4.32000   43.05100  -23.34500 1.000 42.85037  ? 219  LYS B C     1 
ATOM   3617 O O     . LYS B 1 239 ? 3.89000   44.20300  -23.28200 1.000 41.84565  ? 219  LYS B O     1 
ATOM   3618 C CB    . LYS B 1 239 ? 4.89900   41.84400  -21.23500 1.000 46.88541  ? 219  LYS B CB    1 
ATOM   3619 C CG    . LYS B 1 239 ? 4.53900   40.93400  -20.08300 1.000 50.00249  ? 219  LYS B CG    1 
ATOM   3620 C CD    . LYS B 1 239 ? 5.38300   41.25100  -18.85800 1.000 51.23097  ? 219  LYS B CD    1 
ATOM   3621 C CE    . LYS B 1 239 ? 6.12800   40.06800  -18.34700 1.000 56.78027  ? 219  LYS B CE    1 
ATOM   3622 N NZ    . LYS B 1 239 ? 6.65200   40.31500  -17.00300 1.000 49.80639  ? 219  LYS B NZ    1 
ATOM   3623 N N     . ARG B 1 240 ? 5.15100   42.61800  -24.28900 1.000 44.80668  ? 220  ARG B N     1 
ATOM   3624 C CA    . ARG B 1 240 ? 5.74100   43.57200  -25.25700 1.000 43.95689  ? 220  ARG B CA    1 
ATOM   3625 C C     . ARG B 1 240 ? 4.68500   44.05300  -26.25100 1.000 47.00994  ? 220  ARG B C     1 
ATOM   3626 O O     . ARG B 1 240 ? 4.76500   45.21400  -26.66600 1.000 46.23388  ? 220  ARG B O     1 
ATOM   3627 C CB    . ARG B 1 240 ? 6.88400   42.88300  -25.99700 1.000 49.68697  ? 220  ARG B CB    1 
ATOM   3628 C CG    . ARG B 1 240 ? 8.15900   43.68700  -26.18500 1.000 57.80177  ? 220  ARG B CG    1 
ATOM   3629 C CD    . ARG B 1 240 ? 9.16900   42.88300  -26.99100 1.000 57.65178  ? 220  ARG B CD    1 
ATOM   3630 N NE    . ARG B 1 240 ? 9.33700   41.52100  -26.47200 1.000 62.07277  ? 220  ARG B NE    1 
ATOM   3631 C CZ    . ARG B 1 240 ? 9.02400   40.41200  -27.13100 1.000 62.20359  ? 220  ARG B CZ    1 
ATOM   3632 N NH1   . ARG B 1 240 ? 8.45400   40.48900  -28.32000 1.000 57.20280  ? 220  ARG B NH1   1 
ATOM   3633 N NH2   . ARG B 1 240 ? 9.27700   39.23300  -26.59300 1.000 57.90157  ? 220  ARG B NH2   1 
ATOM   3634 N N     . ARG B 1 241 ? 3.73400   43.19100  -26.59700 1.000 41.92319  ? 221  ARG B N     1 
ATOM   3635 C CA    . ARG B 1 241 ? 2.70700   43.55400  -27.60500 1.000 47.96019  ? 221  ARG B CA    1 
ATOM   3636 C C     . ARG B 1 241 ? 1.72600   44.53300  -26.97500 1.000 42.86551  ? 221  ARG B C     1 
ATOM   3637 O O     . ARG B 1 241 ? 1.05900   45.26600  -27.71400 1.000 40.48315  ? 221  ARG B O     1 
ATOM   3638 C CB    . ARG B 1 241 ? 1.94400   42.32300  -28.09600 1.000 44.97266  ? 221  ARG B CB    1 
ATOM   3639 C CG    . ARG B 1 241 ? 2.50200   41.72500  -29.37700 1.000 53.92965  ? 221  ARG B CG    1 
ATOM   3640 C CD    . ARG B 1 241 ? 2.16100   40.25100  -29.46500 1.000 54.80441  ? 221  ARG B CD    1 
ATOM   3641 N NE    . ARG B 1 241 ? 0.73300   40.04900  -29.20500 1.000 46.35191  ? 221  ARG B NE    1 
ATOM   3642 C CZ    . ARG B 1 241 ? 0.18900   38.89400  -28.86700 1.000 48.86909  ? 221  ARG B CZ    1 
ATOM   3643 N NH1   . ARG B 1 241 ? 0.94800   37.82900  -28.70200 1.000 46.83289  ? 221  ARG B NH1   1 
ATOM   3644 N NH2   . ARG B 1 241 ? -1.11600  38.81200  -28.70000 1.000 47.37814  ? 221  ARG B NH2   1 
ATOM   3645 N N     . ALA B 1 242 ? 1.65300   44.51200  -25.65200 1.000 43.00768  ? 222  ALA B N     1 
ATOM   3646 C CA    . ALA B 1 242 ? 0.70600   45.38400  -24.93800 1.000 33.90309  ? 222  ALA B CA    1 
ATOM   3647 C C     . ALA B 1 242 ? 1.00400   46.84900  -25.22400 1.000 35.18252  ? 222  ALA B C     1 
ATOM   3648 O O     . ALA B 1 242 ? 2.16500   47.24400  -25.29300 1.000 36.59818  ? 222  ALA B O     1 
ATOM   3649 C CB    . ALA B 1 242 ? 0.78700   45.09000  -23.46900 1.000 38.13453  ? 222  ALA B CB    1 
ATOM   3650 N N     . GLN B 1 243 ? -0.05500  47.62800  -25.35700 1.000 33.29174  ? 223  GLN B N     1 
ATOM   3651 C CA    . GLN B 1 243 ? 0.09900   49.07800  -25.55600 1.000 35.32226  ? 223  GLN B CA    1 
ATOM   3652 C C     . GLN B 1 243 ? 0.71100   49.65100  -24.28100 1.000 38.12861  ? 223  GLN B C     1 
ATOM   3653 O O     . GLN B 1 243 ? 1.48400   50.60900  -24.37300 1.000 42.23545  ? 223  GLN B O     1 
ATOM   3654 C CB    . GLN B 1 243 ? -1.30900  49.61300  -25.77300 1.000 38.48815  ? 223  GLN B CB    1 
ATOM   3655 C CG    . GLN B 1 243 ? -1.40700  51.13200  -25.74600 1.000 45.89082  ? 223  GLN B CG    1 
ATOM   3656 C CD    . GLN B 1 243 ? -2.80600  51.63000  -25.47100 1.000 56.04668  ? 223  GLN B CD    1 
ATOM   3657 O OE1   . GLN B 1 243 ? -3.70800  51.51200  -26.30600 1.000 56.65584  ? 223  GLN B OE1   1 
ATOM   3658 N NE2   . GLN B 1 243 ? -2.99200  52.20100  -24.29100 1.000 54.20985  ? 223  GLN B NE2   1 
ATOM   3659 N N     . VAL B 1 244 ? 0.36600   49.05800  -23.14100 1.000 35.64618  ? 224  VAL B N     1 
ATOM   3660 C CA    . VAL B 1 244 ? 0.84500   49.58300  -21.83200 1.000 33.33550  ? 224  VAL B CA    1 
ATOM   3661 C C     . VAL B 1 244 ? 0.96300   48.44100  -20.82000 1.000 35.26949  ? 224  VAL B C     1 
ATOM   3662 O O     . VAL B 1 244 ? 0.18100   47.48600  -20.91300 1.000 32.88046  ? 224  VAL B O     1 
ATOM   3663 C CB    . VAL B 1 244 ? -0.08900  50.68500  -21.29800 1.000 33.53535  ? 224  VAL B CB    1 
ATOM   3664 C CG1   . VAL B 1 244 ? -1.52500  50.22000  -21.13300 1.000 31.96666  ? 224  VAL B CG1   1 
ATOM   3665 C CG2   . VAL B 1 244 ? 0.43900   51.33800  -20.02800 1.000 33.15151  ? 224  VAL B CG2   1 
ATOM   3666 N N     . ARG B 1 245 ? 1.95300   48.52300  -19.94000 1.000 27.24173  ? 225  ARG B N     1 
ATOM   3667 C CA    . ARG B 1 245 ? 2.06500   47.55000  -18.83500 1.000 26.39469  ? 225  ARG B CA    1 
ATOM   3668 C C     . ARG B 1 245 ? 1.76000   48.35000  -17.55600 1.000 31.02253  ? 225  ARG B C     1 
ATOM   3669 O O     . ARG B 1 245 ? 2.35400   49.42000  -17.37700 1.000 26.40160  ? 225  ARG B O     1 
ATOM   3670 C CB    . ARG B 1 245 ? 3.40700   46.82100  -18.84600 1.000 31.67103  ? 225  ARG B CB    1 
ATOM   3671 C CG    . ARG B 1 245 ? 3.67800   45.96600  -20.07400 1.000 36.08388  ? 225  ARG B CG    1 
ATOM   3672 C CD    . ARG B 1 245 ? 4.99400   46.30500  -20.75200 1.000 31.31350  ? 225  ARG B CD    1 
ATOM   3673 N NE    . ARG B 1 245 ? 4.97200   47.63600  -21.36500 1.000 35.07008  ? 225  ARG B NE    1 
ATOM   3674 C CZ    . ARG B 1 245 ? 4.43800   47.92300  -22.54200 1.000 37.90005  ? 225  ARG B CZ    1 
ATOM   3675 N NH1   . ARG B 1 245 ? 4.14300   46.95800  -23.39000 1.000 41.36903  ? 225  ARG B NH1   1 
ATOM   3676 N NH2   . ARG B 1 245 ? 4.20800   49.17900  -22.86800 1.000 35.51473  ? 225  ARG B NH2   1 
ATOM   3677 N N     . VAL B 1 246 ? 0.82600   47.85400  -16.75200 1.000 29.65342  ? 226  VAL B N     1 
ATOM   3678 C CA    . VAL B 1 246 ? 0.38300   48.60800  -15.55200 1.000 25.02649  ? 226  VAL B CA    1 
ATOM   3679 C C     . VAL B 1 246 ? 0.61800   47.79400  -14.27700 1.000 27.90921  ? 226  VAL B C     1 
ATOM   3680 O O     . VAL B 1 246 ? 0.49800   46.56200  -14.31600 1.000 25.53896  ? 226  VAL B O     1 
ATOM   3681 C CB    . VAL B 1 246 ? -1.10100  48.98200  -15.70100 1.000 26.26535  ? 226  VAL B CB    1 
ATOM   3682 C CG1   . VAL B 1 246 ? -1.34000  49.98100  -16.82400 1.000 23.35415  ? 226  VAL B CG1   1 
ATOM   3683 C CG2   . VAL B 1 246 ? -1.99800  47.76100  -15.83500 1.000 22.31364  ? 226  VAL B CG2   1 
ATOM   3684 N N     . ARG B 1 247 ? 0.94100   48.50000  -13.20200 1.000 25.62025  ? 227  ARG B N     1 
ATOM   3685 C CA    . ARG B 1 247 ? 1.16200   47.83800  -11.90700 1.000 24.23633  ? 227  ARG B CA    1 
ATOM   3686 C C     . ARG B 1 247 ? 0.17800   48.32900  -10.85100 1.000 24.46555  ? 227  ARG B C     1 
ATOM   3687 O O     . ARG B 1 247 ? -0.27300  49.46800  -10.93000 1.000 23.22096  ? 227  ARG B O     1 
ATOM   3688 C CB    . ARG B 1 247 ? 2.54600   48.12800  -11.33700 1.000 29.69945  ? 227  ARG B CB    1 
ATOM   3689 C CG    . ARG B 1 247 ? 2.83800   49.60600  -11.12800 1.000 33.44815  ? 227  ARG B CG    1 
ATOM   3690 C CD    . ARG B 1 247 ? 4.25100   49.85400  -10.63800 1.000 36.12263  ? 227  ARG B CD    1 
ATOM   3691 N NE    . ARG B 1 247 ? 4.46300   51.25000  -10.24500 1.000 33.30028  ? 227  ARG B NE    1 
ATOM   3692 C CZ    . ARG B 1 247 ? 4.75700   52.23800  -11.07400 1.000 34.38954  ? 227  ARG B CZ    1 
ATOM   3693 N NH1   . ARG B 1 247 ? 4.87100   52.01100  -12.36800 1.000 30.23106  ? 227  ARG B NH1   1 
ATOM   3694 N NH2   . ARG B 1 247 ? 4.93100   53.45700  -10.60600 1.000 30.68188  ? 227  ARG B NH2   1 
ATOM   3695 N N     . ILE B 1 248 ? -0.15300  47.44100  -9.93400  1.000 24.45493  ? 228  ILE B N     1 
ATOM   3696 C CA    . ILE B 1 248 ? -0.95400  47.84400  -8.75700  1.000 25.79724  ? 228  ILE B CA    1 
ATOM   3697 C C     . ILE B 1 248 ? 0.09900   48.18300  -7.69900  1.000 17.68062  ? 228  ILE B C     1 
ATOM   3698 O O     . ILE B 1 248 ? 0.92900   47.33600  -7.39700  1.000 24.02464  ? 228  ILE B O     1 
ATOM   3699 C CB    . ILE B 1 248 ? -1.85000  46.71000  -8.24100  1.000 26.43716  ? 228  ILE B CB    1 
ATOM   3700 C CG1   . ILE B 1 248 ? -2.57600  45.98300  -9.37700  1.000 31.49565  ? 228  ILE B CG1   1 
ATOM   3701 C CG2   . ILE B 1 248 ? -2.81400  47.22600  -7.17600  1.000 27.26319  ? 228  ILE B CG2   1 
ATOM   3702 C CD1   . ILE B 1 248 ? -3.93800  46.54500  -9.71900  1.000 26.84597  ? 228  ILE B CD1   1 
ATOM   3703 N N     . PRO B 1 249 ? 0.08500   49.39900  -7.15300  1.000 21.73823  ? 229  PRO B N     1 
ATOM   3704 C CA    . PRO B 1 249 ? 1.07200   49.77200  -6.15200  1.000 27.64209  ? 229  PRO B CA    1 
ATOM   3705 C C     . PRO B 1 249 ? 1.06200   48.85100  -4.92700  1.000 28.63165  ? 229  PRO B C     1 
ATOM   3706 O O     . PRO B 1 249 ? -0.01700  48.44000  -4.49600  1.000 27.07046  ? 229  PRO B O     1 
ATOM   3707 C CB    . PRO B 1 249 ? 0.69500   51.22200  -5.82900  1.000 28.57082  ? 229  PRO B CB    1 
ATOM   3708 C CG    . PRO B 1 249 ? -0.73600  51.34600  -6.26700  1.000 25.64274  ? 229  PRO B CG    1 
ATOM   3709 C CD    . PRO B 1 249 ? -0.86300  50.43900  -7.46800  1.000 21.69455  ? 229  PRO B CD    1 
ATOM   3710 N N     . MET B 1 250 ? 2.25000   48.51300  -4.40600  1.000 29.50846  ? 230  MET B N     1 
ATOM   3711 C CA    . MET B 1 250 ? 2.36400   47.62600  -3.24700  1.000 26.72844  ? 230  MET B CA    1 
ATOM   3712 C C     . MET B 1 250 ? 3.22400   48.37500  -2.23300  1.000 32.95518  ? 230  MET B C     1 
ATOM   3713 O O     . MET B 1 250 ? 4.41300   48.57000  -2.48300  1.000 32.88455  ? 230  MET B O     1 
ATOM   3714 C CB    . MET B 1 250 ? 3.04200   46.31000  -3.60900  1.000 27.88557  ? 230  MET B CB    1 
ATOM   3715 C CG    . MET B 1 250 ? 2.42200   45.53300  -4.73400  1.000 34.89780  ? 230  MET B CG    1 
ATOM   3716 S SD    . MET B 1 250 ? 0.80700   44.97500  -4.16200  1.000 33.75728  ? 230  MET B SD    1 
ATOM   3717 C CE    . MET B 1 250 ? 1.22700   43.73500  -2.94300  1.000 34.21480  ? 230  MET B CE    1 
ATOM   3718 N N     . ARG B 1 251 ? 2.65000   48.79500  -1.10300  1.000 31.46715  ? 231  ARG B N     1 
ATOM   3719 C CA    . ARG B 1 251 ? 3.35300   49.71100  -0.20700  1.000 34.46032  ? 231  ARG B CA    1 
ATOM   3720 C C     . ARG B 1 251 ? 4.04600   49.02600  0.96300   1.000 36.10259  ? 231  ARG B C     1 
ATOM   3721 O O     . ARG B 1 251 ? 4.77400   49.69300  1.70800   1.000 39.68239  ? 231  ARG B O     1 
ATOM   3722 C CB    . ARG B 1 251 ? 2.39100   50.76600  0.33000   1.000 31.56092  ? 231  ARG B CB    1 
ATOM   3723 C CG    . ARG B 1 251 ? 1.58100   51.46800  -0.71400  1.000 33.30140  ? 231  ARG B CG    1 
ATOM   3724 C CD    . ARG B 1 251 ? 0.92800   52.68000  -0.11600  1.000 36.49768  ? 231  ARG B CD    1 
ATOM   3725 N NE    . ARG B 1 251 ? 1.93900   53.70200  0.10400   1.000 44.29136  ? 231  ARG B NE    1 
ATOM   3726 C CZ    . ARG B 1 251 ? 1.84300   54.67400  1.00500   1.000 50.55437  ? 231  ARG B CZ    1 
ATOM   3727 N NH1   . ARG B 1 251 ? 0.76600   54.74800  1.78300   1.000 43.37491  ? 231  ARG B NH1   1 
ATOM   3728 N NH2   . ARG B 1 251 ? 2.83400   55.56700  1.13300   1.000 43.19831  ? 231  ARG B NH2   1 
ATOM   3729 N N     . GLY B 1 252 ? 3.83000   47.73300  1.16500   1.000 31.53715  ? 232  GLY B N     1 
ATOM   3730 C CA    . GLY B 1 252 ? 4.44500   47.05100  2.28200   1.000 36.88290  ? 232  GLY B CA    1 
ATOM   3731 C C     . GLY B 1 252 ? 5.53500   46.11600  1.83100   1.000 39.41435  ? 232  GLY B C     1 
ATOM   3732 O O     . GLY B 1 252 ? 6.23600   46.40700  0.85500   1.000 42.95058  ? 232  GLY B O     1 
ATOM   3733 N N     . ARG B 1 253 ? 5.65800   44.97800  2.50600   1.000 39.29142  ? 233  ARG B N     1 
ATOM   3734 C CA    . ARG B 1 253 ? 6.62600   43.95800  2.13400   1.000 43.40583  ? 233  ARG B CA    1 
ATOM   3735 C C     . ARG B 1 253 ? 6.09400   42.99200  1.09000   1.000 47.31475  ? 233  ARG B C     1 
ATOM   3736 O O     . ARG B 1 253 ? 6.89900   42.33800  0.41400   1.000 48.77680  ? 233  ARG B O     1 
ATOM   3737 C CB    . ARG B 1 253 ? 7.05000   43.12700  3.35000   1.000 46.80698  ? 233  ARG B CB    1 
ATOM   3738 C CG    . ARG B 1 253 ? 7.42700   43.88900  4.61400   1.000 50.19755  ? 233  ARG B CG    1 
ATOM   3739 C CD    . ARG B 1 253 ? 8.94500   43.95600  4.79900   1.000 51.91447  ? 233  ARG B CD    1 
ATOM   3740 N NE    . ARG B 1 253 ? 9.67200   42.75700  4.35100   1.000 47.20489  ? 233  ARG B NE    1 
ATOM   3741 C CZ    . ARG B 1 253 ? 10.17800  41.82400  5.16000   1.000 46.57256  ? 233  ARG B CZ    1 
ATOM   3742 N NH1   . ARG B 1 253 ? 10.02000  41.91400  6.48300   1.000 42.47491  ? 233  ARG B NH1   1 
ATOM   3743 N NH2   . ARG B 1 253 ? 10.85200  40.79700  4.64700   1.000 45.17684  ? 233  ARG B NH2   1 
ATOM   3744 N N     . ALA B 1 254 ? 4.77100   42.83700  0.97000   1.000 40.96153  ? 234  ALA B N     1 
ATOM   3745 C CA    . ALA B 1 254 ? 4.25900   41.89700  -0.02400  1.000 43.69639  ? 234  ALA B CA    1 
ATOM   3746 C C     . ALA B 1 254 ? 4.62900   42.37700  -1.41600  1.000 44.74604  ? 234  ALA B C     1 
ATOM   3747 O O     . ALA B 1 254 ? 4.63700   43.57900  -1.69700  1.000 44.39992  ? 234  ALA B O     1 
ATOM   3748 C CB    . ALA B 1 254 ? 2.73500   41.73400  0.09500   1.000 41.10150  ? 234  ALA B CB    1 
ATOM   3749 N N     . ASP B 1 255 ? 4.95400   41.42800  -2.28500  1.000 46.96485  ? 235  ASP B N     1 
ATOM   3750 C CA    . ASP B 1 255 ? 5.35900   41.73000  -3.64600  1.000 45.19556  ? 235  ASP B CA    1 
ATOM   3751 C C     . ASP B 1 255 ? 4.20100   41.73500  -4.64100  1.000 42.62920  ? 235  ASP B C     1 
ATOM   3752 O O     . ASP B 1 255 ? 4.31100   42.36800  -5.69600  1.000 39.65976  ? 235  ASP B O     1 
ATOM   3753 C CB    . ASP B 1 255 ? 6.40300   40.70600  -4.12000  1.000 49.86269  ? 235  ASP B CB    1 
ATOM   3754 C CG    . ASP B 1 255 ? 7.75900   40.89800  -3.46600  1.000 62.52743  ? 235  ASP B CG    1 
ATOM   3755 O OD1   . ASP B 1 255 ? 7.92300   41.85600  -2.67400  1.000 68.77394  ? 235  ASP B OD1   1 
ATOM   3756 O OD2   . ASP B 1 255 ? 8.67200   40.08800  -3.74000  1.000 74.39395  ? 235  ASP B OD2   1 
ATOM   3757 N N     . SER B 1 256 ? 3.09300   41.07200  -4.32100  1.000 40.45316  ? 236  SER B N     1 
ATOM   3758 C CA    . SER B 1 256 ? 2.01900   40.85800  -5.27900  1.000 38.24965  ? 236  SER B CA    1 
ATOM   3759 C C     . SER B 1 256 ? 0.73400   40.56500  -4.50900  1.000 35.55208  ? 236  SER B C     1 
ATOM   3760 O O     . SER B 1 256 ? 0.76900   40.21200  -3.32500  1.000 35.84432  ? 236  SER B O     1 
ATOM   3761 C CB    . SER B 1 256 ? 2.35000   39.67800  -6.19700  1.000 39.81039  ? 236  SER B CB    1 
ATOM   3762 O OG    . SER B 1 256 ? 2.24900   38.51200  -5.40300  1.000 40.29340  ? 236  SER B OG    1 
ATOM   3763 N N     . LEU B 1 257 ? -0.37300  40.70100  -5.22700  1.000 33.79835  ? 237  LEU B N     1 
ATOM   3764 C CA    . LEU B 1 257 ? -1.69300  40.43700  -4.63100  1.000 31.03132  ? 237  LEU B CA    1 
ATOM   3765 C C     . LEU B 1 257 ? -2.22900  39.11700  -5.19100  1.000 34.61182  ? 237  LEU B C     1 
ATOM   3766 O O     . LEU B 1 257 ? -1.62900  38.58400  -6.12600  1.000 31.02417  ? 237  LEU B O     1 
ATOM   3767 C CB    . LEU B 1 257 ? -2.60900  41.60100  -4.99200  1.000 29.16599  ? 237  LEU B CB    1 
ATOM   3768 C CG    . LEU B 1 257 ? -2.31800  42.92900  -4.29300  1.000 31.99549  ? 237  LEU B CG    1 
ATOM   3769 C CD1   . LEU B 1 257 ? -3.16800  44.03400  -4.87700  1.000 29.86953  ? 237  LEU B CD1   1 
ATOM   3770 C CD2   . LEU B 1 257 ? -2.54500  42.79400  -2.80200  1.000 28.10998  ? 237  LEU B CD2   1 
ATOM   3771 N N     . ASN B 1 258 ? -3.33000  38.63000  -4.61900  1.000 32.76845  ? 238  ASN B N     1 
ATOM   3772 C CA    . ASN B 1 258 ? -3.99600  37.42600  -5.17300  1.000 37.32538  ? 238  ASN B CA    1 
ATOM   3773 C C     . ASN B 1 258 ? -4.48100  37.76300  -6.59100  1.000 32.40209  ? 238  ASN B C     1 
ATOM   3774 O O     . ASN B 1 258 ? -4.81500  38.92500  -6.84100  1.000 28.12499  ? 238  ASN B O     1 
ATOM   3775 C CB    . ASN B 1 258 ? -5.11400  36.94200  -4.25500  1.000 27.62219  ? 238  ASN B CB    1 
ATOM   3776 C CG    . ASN B 1 258 ? -4.62300  36.43800  -2.91900  1.000 40.35575  ? 238  ASN B CG    1 
ATOM   3777 O OD1   . ASN B 1 258 ? -4.25500  35.26700  -2.79200  1.000 45.31893  ? 238  ASN B OD1   1 
ATOM   3778 N ND2   . ASN B 1 258 ? -4.63300  37.28800  -1.90700  1.000 32.70094  ? 238  ASN B ND2   1 
ATOM   3779 N N     . VAL B 1 259 ? -4.54600  36.76400  -7.46400  1.000 30.26754  ? 239  VAL B N     1 
ATOM   3780 C CA    . VAL B 1 259 ? -4.92300  37.01900  -8.88500  1.000 31.13877  ? 239  VAL B CA    1 
ATOM   3781 C C     . VAL B 1 259 ? -6.38700  37.49700  -8.97800  1.000 27.74842  ? 239  VAL B C     1 
ATOM   3782 O O     . VAL B 1 259 ? -6.66300  38.39600  -9.76400  1.000 27.21570  ? 239  VAL B O     1 
ATOM   3783 C CB    . VAL B 1 259 ? -4.63400  35.78700  -9.76100  1.000 32.65247  ? 239  VAL B CB    1 
ATOM   3784 C CG1   . VAL B 1 259 ? -5.43300  34.56300  -9.33700  1.000 35.63330  ? 239  VAL B CG1   1 
ATOM   3785 C CG2   . VAL B 1 259 ? -4.78900  36.07600  -11.24400 1.000 35.19360  ? 239  VAL B CG2   1 
ATOM   3786 N N     . ALA B 1 260 ? -7.27300  36.91400  -8.17900  1.000 28.93905  ? 240  ALA B N     1 
ATOM   3787 C CA    . ALA B 1 260 ? -8.69600  37.31100  -8.23000  1.000 26.76820  ? 240  ALA B CA    1 
ATOM   3788 C C     . ALA B 1 260 ? -8.81200  38.76100  -7.77500  1.000 23.88814  ? 240  ALA B C     1 
ATOM   3789 O O     . ALA B 1 260 ? -9.57000  39.53200  -8.35800  1.000 23.15046  ? 240  ALA B O     1 
ATOM   3790 C CB    . ALA B 1 260 ? -9.53300  36.40800  -7.36400  1.000 24.68685  ? 240  ALA B CB    1 
ATOM   3791 N N     . VAL B 1 261 ? -8.07600  39.09200  -6.72300  1.000 23.18300  ? 241  VAL B N     1 
ATOM   3792 C CA    . VAL B 1 261 ? -8.09000  40.46700  -6.23600  1.000 24.50664  ? 241  VAL B CA    1 
ATOM   3793 C C     . VAL B 1 261 ? -7.57000  41.41800  -7.32300  1.000 22.34691  ? 241  VAL B C     1 
ATOM   3794 O O     . VAL B 1 261 ? -8.15900  42.46400  -7.58100  1.000 20.73694  ? 241  VAL B O     1 
ATOM   3795 C CB    . VAL B 1 261 ? -7.24500  40.57600  -4.95300  1.000 21.03158  ? 241  VAL B CB    1 
ATOM   3796 C CG1   . VAL B 1 261 ? -6.89300  42.05700  -4.69700  1.000 23.52248  ? 241  VAL B CG1   1 
ATOM   3797 C CG2   . VAL B 1 261 ? -8.02600  40.00100  -3.78700  1.000 25.75233  ? 241  VAL B CG2   1 
ATOM   3798 N N     . THR B 1 262 ? -6.46000  41.05500  -7.95100  1.000 23.26798  ? 242  THR B N     1 
ATOM   3799 C CA    . THR B 1 262 ? -5.89200  41.85800  -9.04900  1.000 27.00215  ? 242  THR B CA    1 
ATOM   3800 C C     . THR B 1 262 ? -6.89600  41.99100  -10.17900 1.000 23.71893  ? 242  THR B C     1 
ATOM   3801 O O     . THR B 1 262 ? -7.09300  43.07800  -10.73800 1.000 21.18537  ? 242  THR B O     1 
ATOM   3802 C CB    . THR B 1 262 ? -4.61800  41.19000  -9.58200  1.000 25.41493  ? 242  THR B CB    1 
ATOM   3803 O OG1   . THR B 1 262 ? -3.65900  41.07300  -8.53900  1.000 29.53759  ? 242  THR B OG1   1 
ATOM   3804 C CG2   . THR B 1 262 ? -3.99200  42.02900  -10.71700 1.000 27.80481  ? 242  THR B CG2   1 
ATOM   3805 N N     . ALA B 1 263 ? -7.53500  40.87200  -10.54900 1.000 23.56551  ? 243  ALA B N     1 
ATOM   3806 C CA    . ALA B 1 263 ? -8.52900  40.95400  -11.61200 1.000 23.44697  ? 243  ALA B CA    1 
ATOM   3807 C C     . ALA B 1 263 ? -9.63300  41.91600  -11.22100 1.000 22.66815  ? 243  ALA B C     1 
ATOM   3808 O O     . ALA B 1 263 ? -9.99700  42.79400  -12.00600 1.000 20.41635  ? 243  ALA B O     1 
ATOM   3809 C CB    . ALA B 1 263 ? -9.10300  39.56000  -11.92400 1.000 27.42032  ? 243  ALA B CB    1 
ATOM   3810 N N     . ALA B 1 264 ? -10.12600 41.84900  -9.99400  1.000 18.84835  ? 244  ALA B N     1 
ATOM   3811 C CA    . ALA B 1 264 ? -11.18600 42.79600  -9.57100  1.000 17.60378  ? 244  ALA B CA    1 
ATOM   3812 C C     . ALA B 1 264 ? -10.71000 44.25600  -9.62300  1.000 16.41796  ? 244  ALA B C     1 
ATOM   3813 O O     . ALA B 1 264 ? -11.41800 45.11200  -10.12400 1.000 21.88831  ? 244  ALA B O     1 
ATOM   3814 C CB    . ALA B 1 264 ? -11.67200 42.42200  -8.19600  1.000 23.60185  ? 244  ALA B CB    1 
ATOM   3815 N N     . LEU B 1 265 ? -9.52100  44.51600  -9.09600  1.000 18.85971  ? 245  LEU B N     1 
ATOM   3816 C CA    . LEU B 1 265 ? -8.99800  45.90000  -9.04800  1.000 17.25094  ? 245  LEU B CA    1 
ATOM   3817 C C     . LEU B 1 265 ? -8.96600  46.48300  -10.47000 1.000 18.89981  ? 245  LEU B C     1 
ATOM   3818 O O     . LEU B 1 265 ? -9.43100  47.60100  -10.67200 1.000 18.16799  ? 245  LEU B O     1 
ATOM   3819 C CB    . LEU B 1 265 ? -7.61500  45.82400  -8.41800  1.000 17.18139  ? 245  LEU B CB    1 
ATOM   3820 C CG    . LEU B 1 265 ? -7.58500  45.63400  -6.90000  1.000 24.82733  ? 245  LEU B CG    1 
ATOM   3821 C CD1   . LEU B 1 265 ? -6.16400  45.47200  -6.41800  1.000 25.79353  ? 245  LEU B CD1   1 
ATOM   3822 C CD2   . LEU B 1 265 ? -8.24800  46.80300  -6.21100  1.000 22.80001  ? 245  LEU B CD2   1 
ATOM   3823 N N     . LEU B 1 266 ? -8.44000  45.70800  -11.40700 1.000 18.60364  ? 246  LEU B N     1 
ATOM   3824 C CA    . LEU B 1 266 ? -8.32000  46.18900  -12.80500 1.000 18.75762  ? 246  LEU B CA    1 
ATOM   3825 C C     . LEU B 1 266 ? -9.71200  46.44200  -13.39200 1.000 20.76364  ? 246  LEU B C     1 
ATOM   3826 O O     . LEU B 1 266 ? -9.94600  47.52500  -13.91300 1.000 20.70558  ? 246  LEU B O     1 
ATOM   3827 C CB    . LEU B 1 266 ? -7.55200  45.15100  -13.60800 1.000 20.06143  ? 246  LEU B CB    1 
ATOM   3828 C CG    . LEU B 1 266 ? -6.10700  44.89500  -13.18200 1.000 25.93241  ? 246  LEU B CG    1 
ATOM   3829 C CD1   . LEU B 1 266 ? -5.64700  43.60400  -13.82200 1.000 22.63671  ? 246  LEU B CD1   1 
ATOM   3830 C CD2   . LEU B 1 266 ? -5.22100  46.05100  -13.59700 1.000 21.50629  ? 246  LEU B CD2   1 
ATOM   3831 N N     . LEU B 1 267 ? -10.60600 45.47300  -13.24600 1.000 22.33441  ? 247  LEU B N     1 
ATOM   3832 C CA    . LEU B 1 267 ? -11.94500 45.59000  -13.88200 1.000 19.38427  ? 247  LEU B CA    1 
ATOM   3833 C C     . LEU B 1 267 ? -12.74900 46.75400  -13.27900 1.000 21.14299  ? 247  LEU B C     1 
ATOM   3834 O O     . LEU B 1 267 ? -13.38500 47.48300  -14.03900 1.000 21.09677  ? 247  LEU B O     1 
ATOM   3835 C CB    . LEU B 1 267 ? -12.67500 44.25500  -13.77700 1.000 23.60521  ? 247  LEU B CB    1 
ATOM   3836 C CG    . LEU B 1 267 ? -12.04800 43.09700  -14.55700 1.000 28.53140  ? 247  LEU B CG    1 
ATOM   3837 C CD1   . LEU B 1 267 ? -12.69100 41.77200  -14.21500 1.000 28.13598  ? 247  LEU B CD1   1 
ATOM   3838 C CD2   . LEU B 1 267 ? -12.10000 43.35000  -16.04600 1.000 27.24907  ? 247  LEU B CD2   1 
ATOM   3839 N N     . TYR B 1 268 ? -12.70600 46.91100  -11.95700 1.000 22.78956  ? 248  TYR B N     1 
ATOM   3840 C CA    . TYR B 1 268 ? -13.51400 47.98000  -11.30700 1.000 18.97011  ? 248  TYR B CA    1 
ATOM   3841 C C     . TYR B 1 268 ? -12.89600 49.34700  -11.63000 1.000 19.01681  ? 248  TYR B C     1 
ATOM   3842 O O     . TYR B 1 268 ? -13.62100 50.33900  -11.67200 1.000 23.61728  ? 248  TYR B O     1 
ATOM   3843 C CB    . TYR B 1 268 ? -13.70200 47.66900  -9.82300  1.000 19.16505  ? 248  TYR B CB    1 
ATOM   3844 C CG    . TYR B 1 268 ? -14.89500 46.75000  -9.61300  1.000 17.71825  ? 248  TYR B CG    1 
ATOM   3845 C CD1   . TYR B 1 268 ? -16.18400 47.25900  -9.60900  1.000 22.41436  ? 248  TYR B CD1   1 
ATOM   3846 C CD2   . TYR B 1 268 ? -14.73900 45.37800  -9.46100  1.000 15.93925  ? 248  TYR B CD2   1 
ATOM   3847 C CE1   . TYR B 1 268 ? -17.28200 46.43800  -9.43500  1.000 21.20643  ? 248  TYR B CE1   1 
ATOM   3848 C CE2   . TYR B 1 268 ? -15.83100 44.54600  -9.28000  1.000 19.04165  ? 248  TYR B CE2   1 
ATOM   3849 C CZ    . TYR B 1 268 ? -17.10800 45.07900  -9.26500  1.000 20.76526  ? 248  TYR B CZ    1 
ATOM   3850 O OH    . TYR B 1 268 ? -18.21100 44.30200  -9.09800  1.000 23.34464  ? 248  TYR B OH    1 
ATOM   3851 N N     . GLU B 1 269 ? -11.58600 49.38200  -11.85300 1.000 21.98796  ? 249  GLU B N     1 
ATOM   3852 C CA    . GLU B 1 269 ? -10.94800 50.65300  -12.28000 1.000 20.38724  ? 249  GLU B CA    1 
ATOM   3853 C C     . GLU B 1 269 ? -11.53400 51.07400  -13.63900 1.000 21.69550  ? 249  GLU B C     1 
ATOM   3854 O O     . GLU B 1 269 ? -11.86800 52.23400  -13.82300 1.000 23.55639  ? 249  GLU B O     1 
ATOM   3855 C CB    . GLU B 1 269 ? -9.43100  50.50800  -12.36500 1.000 20.27889  ? 249  GLU B CB    1 
ATOM   3856 C CG    . GLU B 1 269 ? -8.72900  51.71000  -12.99000 1.000 19.77201  ? 249  GLU B CG    1 
ATOM   3857 C CD    . GLU B 1 269 ? -9.01300  53.08900  -12.41800 1.000 24.13774  ? 249  GLU B CD    1 
ATOM   3858 O OE1   . GLU B 1 269 ? -9.50600  53.20500  -11.28500 1.000 24.88118  ? 249  GLU B OE1   1 
ATOM   3859 O OE2   . GLU B 1 269 ? -8.73200  54.06500  -13.13200 1.000 28.99609  ? 249  GLU B OE2   1 
ATOM   3860 N N     . ALA B 1 270 ? -11.64700 50.11900  -14.55000 1.000 25.36794  ? 250  ALA B N     1 
ATOM   3861 C CA    . ALA B 1 270 ? -12.21800 50.41300  -15.88200 1.000 22.24938  ? 250  ALA B CA    1 
ATOM   3862 C C     . ALA B 1 270 ? -13.66500 50.87800  -15.71500 1.000 23.43140  ? 250  ALA B C     1 
ATOM   3863 O O     . ALA B 1 270 ? -14.08100 51.84800  -16.33500 1.000 26.11624  ? 250  ALA B O     1 
ATOM   3864 C CB    . ALA B 1 270 ? -12.10100 49.18800  -16.73300 1.000 26.93002  ? 250  ALA B CB    1 
ATOM   3865 N N     . LEU B 1 271 ? -14.39200 50.21300  -14.82800 1.000 25.94469  ? 251  LEU B N     1 
ATOM   3866 C CA    . LEU B 1 271 ? -15.80000 50.59300  -14.56900 1.000 25.51352  ? 251  LEU B CA    1 
ATOM   3867 C C     . LEU B 1 271 ? -15.84000 52.02400  -14.01200 1.000 28.92934  ? 251  LEU B C     1 
ATOM   3868 O O     . LEU B 1 271 ? -16.72100 52.78700  -14.39600 1.000 29.45210  ? 251  LEU B O     1 
ATOM   3869 C CB    . LEU B 1 271 ? -16.43900 49.59000  -13.61100 1.000 27.93715  ? 251  LEU B CB    1 
ATOM   3870 C CG    . LEU B 1 271 ? -17.90200 49.22900  -13.85400 1.000 36.14334  ? 251  LEU B CG    1 
ATOM   3871 C CD1   . LEU B 1 271 ? -18.04900 48.72700  -15.27500 1.000 35.44842  ? 251  LEU B CD1   1 
ATOM   3872 C CD2   . LEU B 1 271 ? -18.29500 48.15200  -12.86200 1.000 34.54167  ? 251  LEU B CD2   1 
ATOM   3873 N N     . ARG B 1 272 ? -14.90900 52.34300  -13.11800 1.000 24.89413  ? 252  ARG B N     1 
ATOM   3874 C CA    . ARG B 1 272 ? -14.88400 53.69300  -12.51200 1.000 23.64713  ? 252  ARG B CA    1 
ATOM   3875 C C     . ARG B 1 272 ? -14.77000 54.71100  -13.64800 1.000 22.37228  ? 252  ARG B C     1 
ATOM   3876 O O     . ARG B 1 272 ? -15.53300 55.66900  -13.65500 1.000 28.23142  ? 252  ARG B O     1 
ATOM   3877 C CB    . ARG B 1 272 ? -13.72200 53.88200  -11.53600 1.000 23.09333  ? 252  ARG B CB    1 
ATOM   3878 C CG    . ARG B 1 272 ? -13.68300 55.22400  -10.82400 1.000 25.37428  ? 252  ARG B CG    1 
ATOM   3879 C CD    . ARG B 1 272 ? -12.41000 55.40000  -10.02100 1.000 25.22123  ? 252  ARG B CD    1 
ATOM   3880 N NE    . ARG B 1 272 ? -11.20300 55.47400  -10.85100 1.000 27.33950  ? 252  ARG B NE    1 
ATOM   3881 C CZ    . ARG B 1 272 ? -10.77400 56.55800  -11.48100 1.000 27.01541  ? 252  ARG B CZ    1 
ATOM   3882 N NH1   . ARG B 1 272 ? -11.42500 57.69600  -11.36400 1.000 28.18521  ? 252  ARG B NH1   1 
ATOM   3883 N NH2   . ARG B 1 272 ? -9.68600  56.50200  -12.22100 1.000 27.23530  ? 252  ARG B NH2   1 
ATOM   3884 N N     . GLN B 1 273 ? -13.84000 54.46500  -14.56200 1.000 26.08942  ? 253  GLN B N     1 
ATOM   3885 C CA    . GLN B 1 273 ? -13.59600 55.42800  -15.66700 1.000 27.86539  ? 253  GLN B CA    1 
ATOM   3886 C C     . GLN B 1 273 ? -14.85000 55.50800  -16.55200 1.000 30.88442  ? 253  GLN B C     1 
ATOM   3887 O O     . GLN B 1 273 ? -15.21100 56.61700  -16.95100 1.000 33.56581  ? 253  GLN B O     1 
ATOM   3888 C CB    . GLN B 1 273 ? -12.33600 55.04600  -16.43800 1.000 25.24884  ? 253  GLN B CB    1 
ATOM   3889 C CG    . GLN B 1 273 ? -11.04600 55.16700  -15.63500 1.000 25.51699  ? 253  GLN B CG    1 
ATOM   3890 C CD    . GLN B 1 273 ? -9.80900  54.94800  -16.47600 1.000 26.66507  ? 253  GLN B CD    1 
ATOM   3891 O OE1   . GLN B 1 273 ? -9.86400  54.96200  -17.70800 1.000 27.51849  ? 253  GLN B OE1   1 
ATOM   3892 N NE2   . GLN B 1 273 ? -8.67800  54.74900  -15.81900 1.000 23.93853  ? 253  GLN B NE2   1 
ATOM   3893 N N     . ARG B 1 274 ? -15.48800 54.36900  -16.80600 1.000 27.70696  ? 254  ARG B N     1 
ATOM   3894 C CA    . ARG B 1 274 ? -16.71000 54.33700  -17.64500 1.000 30.00286  ? 254  ARG B CA    1 
ATOM   3895 C C     . ARG B 1 274 ? -17.88000 54.97800  -16.89700 1.000 35.26858  ? 254  ARG B C     1 
ATOM   3896 O O     . ARG B 1 274 ? -18.87300 55.31500  -17.54400 1.000 35.93169  ? 254  ARG B O     1 
ATOM   3897 C CB    . ARG B 1 274 ? -16.99700 52.89500  -18.04900 1.000 29.33458  ? 254  ARG B CB    1 
ATOM   3898 C CG    . ARG B 1 274 ? -16.00400 52.43500  -19.09900 1.000 33.11776  ? 254  ARG B CG    1 
ATOM   3899 C CD    . ARG B 1 274 ? -15.86300 50.94000  -19.04300 1.000 34.26207  ? 254  ARG B CD    1 
ATOM   3900 N NE    . ARG B 1 274 ? -14.92100 50.51000  -20.07600 1.000 39.44452  ? 254  ARG B NE    1 
ATOM   3901 C CZ    . ARG B 1 274 ? -15.20100 49.58600  -20.97200 1.000 36.95372  ? 254  ARG B CZ    1 
ATOM   3902 N NH1   . ARG B 1 274 ? -16.35900 48.95900  -20.93600 1.000 34.27613  ? 254  ARG B NH1   1 
ATOM   3903 N NH2   . ARG B 1 274 ? -14.31500 49.29100  -21.89600 1.000 39.91400  ? 254  ARG B NH2   1 
ATOM   3904 N N     . SER B 1 275 ? -17.74400 55.14900  -15.58900 1.000 30.88832  ? 255  SER B N     1 
ATOM   3905 C CA    . SER B 1 275 ? -18.80600 55.80800  -14.79900 1.000 32.04920  ? 255  SER B CA    1 
ATOM   3906 C C     . SER B 1 275 ? -18.52600 57.31100  -14.65300 1.000 37.55779  ? 255  SER B C     1 
ATOM   3907 O O     . SER B 1 275 ? -19.27300 57.96400  -13.92300 1.000 45.09656  ? 255  SER B O     1 
ATOM   3908 C CB    . SER B 1 275 ? -18.95500 55.12600  -13.47200 1.000 35.81014  ? 255  SER B CB    1 
ATOM   3909 O OG    . SER B 1 275 ? -19.07400 53.72000  -13.62600 1.000 40.47145  ? 255  SER B OG    1 
ATOM   3910 N N     . GLY B 1 276 ? -17.49300 57.82800  -15.32200 1.000 36.16190  ? 256  GLY B N     1 
ATOM   3911 C CA    . GLY B 1 276 ? -17.19200 59.27200  -15.28100 1.000 33.46325  ? 256  GLY B CA    1 
ATOM   3912 C C     . GLY B 1 276 ? -15.85100 59.58900  -14.64400 1.000 37.14780  ? 256  GLY B C     1 
ATOM   3913 O O     . GLY B 1 276 ? -15.47400 60.76500  -14.62800 1.000 36.93280  ? 256  GLY B O     1 
ATOM   3914 N N     . GLY B 1 277 ? -15.16900 58.58000  -14.12000 1.000 34.68886  ? 257  GLY B N     1 
ATOM   3915 C CA    . GLY B 1 277 ? -13.87400 58.78500  -13.46600 1.000 32.18759  ? 257  GLY B CA    1 
ATOM   3916 C C     . GLY B 1 277 ? -12.80700 59.12000  -14.47700 1.000 34.08037  ? 257  GLY B C     1 
ATOM   3917 O O     . GLY B 1 277 ? -12.88100 58.62800  -15.60600 1.000 33.23461  ? 257  GLY B O     1 
ATOM   3918 N N     . ALA B 1 278 ? -11.82100 59.90700  -14.06900 1.000 33.71064  ? 258  ALA B N     1 
ATOM   3919 C CA    . ALA B 1 278 ? -10.75100 60.16400  -15.02100 1.000 32.01547  ? 258  ALA B CA    1 
ATOM   3920 C C     . ALA B 1 278 ? -9.53300  59.32000  -14.70800 1.000 28.31065  ? 258  ALA B C     1 
ATOM   3921 O O     . ALA B 1 278 ? -9.26900  59.01600  -13.54300 1.000 28.07145  ? 258  ALA B O     1 
ATOM   3922 C CB    . ALA B 1 278 ? -10.33900 61.65300  -14.96500 1.000 30.49423  ? 258  ALA B CB    1 
ATOM   3923 N N     . PRO B 1 279 ? -8.72400  58.97300  -15.70800 1.000 27.47975  ? 259  PRO B N     1 
ATOM   3924 C CA    . PRO B 1 279 ? -7.41600  58.39000  -15.41400 1.000 27.34392  ? 259  PRO B CA    1 
ATOM   3925 C C     . PRO B 1 279 ? -6.62000  59.30300  -14.48500 1.000 27.52363  ? 259  PRO B C     1 
ATOM   3926 O O     . PRO B 1 279 ? -6.73500  60.52500  -14.55800 1.000 26.98243  ? 259  PRO B O     1 
ATOM   3927 C CB    . PRO B 1 279 ? -6.76300  58.27600  -16.79600 1.000 29.91320  ? 259  PRO B CB    1 
ATOM   3928 C CG    . PRO B 1 279 ? -7.91600  58.20600  -17.75000 1.000 28.94714  ? 259  PRO B CG    1 
ATOM   3929 C CD    . PRO B 1 279 ? -8.98700  59.06800  -17.15700 1.000 28.55124  ? 259  PRO B CD    1 
ATOM   3930 N N     . LEU B 1 280 ? -5.85500  58.69600  -13.57400 1.000 25.50144  ? 260  LEU B N     1 
ATOM   3931 C CA    . LEU B 1 280 ? -5.04700  59.44200  -12.60400 1.000 26.43100  ? 260  LEU B CA    1 
ATOM   3932 C C     . LEU B 1 280 ? -3.95300  60.25200  -13.32500 1.000 29.21985  ? 260  LEU B C     1 
ATOM   3933 O O     . LEU B 1 280 ? -3.39300  59.75700  -14.30500 1.000 27.46428  ? 260  LEU B O     1 
ATOM   3934 C CB    . LEU B 1 280 ? -4.39000  58.51300  -11.59400 1.000 23.15732  ? 260  LEU B CB    1 
ATOM   3935 C CG    . LEU B 1 280 ? -3.51500  59.23900  -10.53200 1.000 24.95561  ? 260  LEU B CG    1 
ATOM   3936 C CD1   . LEU B 1 280 ? -4.35200  60.25100  -9.69400  1.000 22.72886  ? 260  LEU B CD1   1 
ATOM   3937 C CD2   . LEU B 1 280 ? -2.85200  58.23200  -9.65000  1.000 22.07049  ? 260  LEU B CD2   1 
ATOM   3938 O OXT   . LEU B 1 280 ? -3.64500  61.38700  -12.93500 1.000 27.84278  ? 260  LEU B OXT   1 
ATOM   3939 O "O5'" . G   C 2 1   ? -29.39700 5.25900   6.25200   1.000 65.33313  ? 2513 G   C "O5'" 1 
ATOM   3940 C "C5'" . G   C 2 1   ? -30.81700 4.98500   6.28300   1.000 65.29335  ? 2513 G   C "C5'" 1 
ATOM   3941 C "C4'" . G   C 2 1   ? -31.08500 3.67600   5.58600   1.000 63.24335  ? 2513 G   C "C4'" 1 
ATOM   3942 O "O4'" . G   C 2 1   ? -30.39900 3.66800   4.30900   1.000 63.04720  ? 2513 G   C "O4'" 1 
ATOM   3943 C "C3'" . G   C 2 1   ? -30.57700 2.41600   6.29500   1.000 65.45335  ? 2513 G   C "C3'" 1 
ATOM   3944 O "O3'" . G   C 2 1   ? -31.50200 1.95900   7.27300   1.000 63.79335  ? 2513 G   C "O3'" 1 
ATOM   3945 C "C2'" . G   C 2 1   ? -30.45600 1.44800   5.11800   1.000 65.25479  ? 2513 G   C "C2'" 1 
ATOM   3946 O "O2'" . G   C 2 1   ? -31.69200 0.87500   4.75300   1.000 60.79042  ? 2513 G   C "O2'" 1 
ATOM   3947 C "C1'" . G   C 2 1   ? -29.93000 2.36900   4.02000   1.000 64.07821  ? 2513 G   C "C1'" 1 
ATOM   3948 N N9    . G   C 2 1   ? -28.47600 2.40800   3.93200   1.000 66.30112  ? 2513 G   C N9    1 
ATOM   3949 C C8    . G   C 2 1   ? -27.66800 3.48800   4.18000   1.000 61.72977  ? 2513 G   C C8    1 
ATOM   3950 N N7    . G   C 2 1   ? -26.39600 3.22900   4.01500   1.000 63.73256  ? 2513 G   C N7    1 
ATOM   3951 C C5    . G   C 2 1   ? -26.36300 1.89600   3.63500   1.000 66.90157  ? 2513 G   C C5    1 
ATOM   3952 C C6    . G   C 2 1   ? -25.25900 1.06800   3.32700   1.000 69.73308  ? 2513 G   C C6    1 
ATOM   3953 O O6    . G   C 2 1   ? -24.05700 1.36300   3.33600   1.000 69.75510  ? 2513 G   C O6    1 
ATOM   3954 N N1    . G   C 2 1   ? -25.67000 -0.22100  2.98900   1.000 72.19275  ? 2513 G   C N1    1 
ATOM   3955 C C2    . G   C 2 1   ? -26.97200 -0.65400  2.95500   1.000 66.25878  ? 2513 G   C C2    1 
ATOM   3956 N N2    . G   C 2 1   ? -27.17200 -1.93200  2.61300   1.000 65.13035  ? 2513 G   C N2    1 
ATOM   3957 N N3    . G   C 2 1   ? -28.01300 0.12100   3.24700   1.000 65.35866  ? 2513 G   C N3    1 
ATOM   3958 C C4    . G   C 2 1   ? -27.63700 1.37800   3.57800   1.000 67.44117  ? 2513 G   C C4    1 
ATOM   3959 P P     . U   C 2 2   ? -31.00400 1.41800   8.70100   1.000 71.82557  ? 2514 U   C P     1 
ATOM   3960 O OP1   . U   C 2 2   ? -32.13900 0.96400   9.58400   1.000 62.73335  ? 2514 U   C OP1   1 
ATOM   3961 O OP2   . U   C 2 2   ? -30.04500 2.36700   9.37900   1.000 70.11335  ? 2514 U   C OP2   1 
ATOM   3962 O "O5'" . U   C 2 2   ? -30.16000 0.10400   8.32600   1.000 72.32335  ? 2514 U   C "O5'" 1 
ATOM   3963 C "C5'" . U   C 2 2   ? -30.87400 -1.11900  8.03300   1.000 65.92335  ? 2514 U   C "C5'" 1 
ATOM   3964 C "C4'" . U   C 2 2   ? -29.92800 -2.10400  7.39500   1.000 69.43335  ? 2514 U   C "C4'" 1 
ATOM   3965 O "O4'" . U   C 2 2   ? -29.15900 -1.44600  6.35600   1.000 69.57335  ? 2514 U   C "O4'" 1 
ATOM   3966 C "C3'" . U   C 2 2   ? -28.86400 -2.69900  8.32300   1.000 72.48335  ? 2514 U   C "C3'" 1 
ATOM   3967 O "O3'" . U   C 2 2   ? -29.39900 -3.77100  9.09400   1.000 76.66335  ? 2514 U   C "O3'" 1 
ATOM   3968 C "C2'" . U   C 2 2   ? -27.79600 -3.13700  7.31600   1.000 72.36335  ? 2514 U   C "C2'" 1 
ATOM   3969 O "O2'" . U   C 2 2   ? -28.08100 -4.37000  6.69200   1.000 71.66040  ? 2514 U   C "O2'" 1 
ATOM   3970 C "C1'" . U   C 2 2   ? -27.87800 -2.03200  6.26000   1.000 71.01335  ? 2514 U   C "C1'" 1 
ATOM   3971 N N1    . U   C 2 2   ? -26.85500 -0.98200  6.44300   1.000 75.10335  ? 2514 U   C N1    1 
ATOM   3972 C C2    . U   C 2 2   ? -25.55600 -1.30300  6.09900   1.000 78.72335  ? 2514 U   C C2    1 
ATOM   3973 O O2    . U   C 2 2   ? -25.24200 -2.39500  5.65000   1.000 80.74335  ? 2514 U   C O2    1 
ATOM   3974 N N3    . U   C 2 2   ? -24.64300 -0.29700  6.28500   1.000 76.12335  ? 2514 U   C N3    1 
ATOM   3975 C C4    . U   C 2 2   ? -24.89200 0.97000   6.77200   1.000 74.13335  ? 2514 U   C C4    1 
ATOM   3976 O O4    . U   C 2 2   ? -23.96300 1.76800   6.88300   1.000 74.90335  ? 2514 U   C O4    1 
ATOM   3977 C C5    . U   C 2 2   ? -26.26200 1.22500   7.10800   1.000 71.88335  ? 2514 U   C C5    1 
ATOM   3978 C C6    . U   C 2 2   ? -27.17700 0.26100   6.93100   1.000 73.23335  ? 2514 U   C C6    1 
ATOM   3979 P P     . C   C 2 3   ? -28.86700 -4.11700  10.57500  1.000 82.29335  ? 2515 C   C P     1 
ATOM   3980 O OP1   . C   C 2 3   ? -29.85500 -4.96700  11.33500  1.000 76.57335  ? 2515 C   C OP1   1 
ATOM   3981 O OP2   . C   C 2 3   ? -28.43300 -2.87800  11.33800  1.000 77.82335  ? 2515 C   C OP2   1 
ATOM   3982 O "O5'" . C   C 2 3   ? -27.54500 -5.02000  10.40300  1.000 80.57335  ? 2515 C   C "O5'" 1 
ATOM   3983 C "C5'" . C   C 2 3   ? -27.58700 -6.16600  9.52400   1.000 79.78335  ? 2515 C   C "C5'" 1 
ATOM   3984 C "C4'" . C   C 2 3   ? -26.17300 -6.59700  9.23200   1.000 87.57335  ? 2515 C   C "C4'" 1 
ATOM   3985 O "O4'" . C   C 2 3   ? -25.57500 -5.69300  8.27000   1.000 85.58335  ? 2515 C   C "O4'" 1 
ATOM   3986 C "C3'" . C   C 2 3   ? -25.21400 -6.54000  10.42400  1.000 91.39335  ? 2515 C   C "C3'" 1 
ATOM   3987 O "O3'" . C   C 2 3   ? -25.33700 -7.69000  11.24700  1.000 91.08373  ? 2515 C   C "O3'" 1 
ATOM   3988 C "C2'" . C   C 2 3   ? -23.85800 -6.46300  9.72100   1.000 90.69335  ? 2515 C   C "C2'" 1 
ATOM   3989 O "O2'" . C   C 2 3   ? -23.40500 -7.72500  9.28200   1.000 92.67400  ? 2515 C   C "O2'" 1 
ATOM   3990 C "C1'" . C   C 2 3   ? -24.18800 -5.58400  8.51000   1.000 87.78335  ? 2515 C   C "C1'" 1 
ATOM   3991 N N1    . C   C 2 3   ? -23.84700 -4.15300  8.72700   1.000 87.99335  ? 2515 C   C N1    1 
ATOM   3992 C C2    . C   C 2 3   ? -22.51900 -3.75800  8.56200   1.000 88.98899  ? 2515 C   C C2    1 
ATOM   3993 O O2    . C   C 2 3   ? -21.67600 -4.60400  8.23500   1.000 89.11581  ? 2515 C   C O2    1 
ATOM   3994 N N3    . C   C 2 3   ? -22.19200 -2.46200  8.75600   1.000 88.16335  ? 2515 C   C N3    1 
ATOM   3995 C C4    . C   C 2 3   ? -23.12600 -1.57200  9.10300   1.000 86.37335  ? 2515 C   C C4    1 
ATOM   3996 N N4    . C   C 2 3   ? -22.74300 -0.31600  9.27800   1.000 84.82335  ? 2515 C   C N4    1 
ATOM   3997 C C5    . C   C 2 3   ? -24.48000 -1.95700  9.28100   1.000 83.14335  ? 2515 C   C C5    1 
ATOM   3998 C C6    . C   C 2 3   ? -24.79600 -3.24400  9.08600   1.000 82.94335  ? 2515 C   C C6    1 
ATOM   3999 P P     . G   C 2 4   ? -25.21100 -7.55400  12.84000  1.000 98.94973  ? 2516 G   C P     1 
ATOM   4000 O OP1   . G   C 2 4   ? -26.23400 -8.37200  13.59900  1.000 98.42159  ? 2516 G   C OP1   1 
ATOM   4001 O OP2   . G   C 2 4   ? -25.13800 -6.10700  13.27100  1.000 95.56127  ? 2516 G   C OP2   1 
ATOM   4002 O "O5'" . G   C 2 4   ? -23.77300 -8.20600  13.11300  1.000 94.41168  ? 2516 G   C "O5'" 1 
ATOM   4003 C "C5'" . G   C 2 4   ? -22.62200 -7.33800  13.09700  1.000 96.07800  ? 2516 G   C "C5'" 1 
ATOM   4004 C "C4'" . G   C 2 4   ? -21.45900 -8.05000  12.45500  1.000 97.24799  ? 2516 G   C "C4'" 1 
ATOM   4005 O "O4'" . G   C 2 4   ? -21.21500 -7.48200  11.14300  1.000 96.57947  ? 2516 G   C "O4'" 1 
ATOM   4006 C "C3'" . G   C 2 4   ? -20.13600 -7.93500  13.22000  1.000 98.37064  ? 2516 G   C "C3'" 1 
ATOM   4007 O "O3'" . G   C 2 4   ? -19.91000 -9.12700  13.95600  1.000 97.67185  ? 2516 G   C "O3'" 1 
ATOM   4008 C "C2'" . G   C 2 4   ? -19.09500 -7.70400  12.12100  1.000 98.78837  ? 2516 G   C "C2'" 1 
ATOM   4009 O "O2'" . G   C 2 4   ? -18.54300 -8.90000  11.61600  1.000 94.91726  ? 2516 G   C "O2'" 1 
ATOM   4010 C "C1'" . G   C 2 4   ? -19.91200 -6.95300  11.07500  1.000 98.14397  ? 2516 G   C "C1'" 1 
ATOM   4011 N N9    . G   C 2 4   ? -19.97200 -5.51300  11.29700  1.000 99.80063  ? 2516 G   C N9    1 
ATOM   4012 C C8    . G   C 2 4   ? -21.07900 -4.76800  11.61700  1.000 97.01037  ? 2516 G   C C8    1 
ATOM   4013 N N7    . G   C 2 4   ? -20.82500 -3.49100  11.74900  1.000 96.50833  ? 2516 G   C N7    1 
ATOM   4014 C C5    . G   C 2 4   ? -19.46500 -3.38700  11.49400  1.000 99.56173  ? 2516 G   C C5    1 
ATOM   4015 C C6    . G   C 2 4   ? -18.62900 -2.24600  11.49000  1.000 102.54701 ? 2516 G   C C6    1 
ATOM   4016 O O6    . G   C 2 4   ? -18.94300 -1.07100  11.72100  1.000 101.04845 ? 2516 G   C O6    1 
ATOM   4017 N N1    . G   C 2 4   ? -17.31100 -2.58200  11.18100  1.000 104.63865 ? 2516 G   C N1    1 
ATOM   4018 C C2    . G   C 2 4   ? -16.86100 -3.85300  10.91500  1.000 102.44375 ? 2516 G   C C2    1 
ATOM   4019 N N2    . G   C 2 4   ? -15.55900 -3.98500  10.63500  1.000 101.42964 ? 2516 G   C N2    1 
ATOM   4020 N N3    . G   C 2 4   ? -17.64400 -4.92800  10.91500  1.000 99.98846  ? 2516 G   C N3    1 
ATOM   4021 C C4    . G   C 2 4   ? -18.92800 -4.62300  11.21600  1.000 100.14640 ? 2516 G   C C4    1 
ATOM   4022 P P     . C   C 2 5   ? -18.96600 -9.11600  15.25100  1.000 98.50335  ? 2517 C   C P     1 
ATOM   4023 O OP1   . C   C 2 5   ? -19.15500 -10.31800 16.14800  1.000 97.29916  ? 2517 C   C OP1   1 
ATOM   4024 O OP2   . C   C 2 5   ? -18.91700 -7.80500  15.99000  1.000 97.62830  ? 2517 C   C OP2   1 
ATOM   4025 O "O5'" . C   C 2 5   ? -17.54500 -9.27600  14.52800  1.000 97.06483  ? 2517 C   C "O5'" 1 
ATOM   4026 C "C5'" . C   C 2 5   ? -16.35700 -9.15300  15.33100  1.000 93.45595  ? 2517 C   C "C5'" 1 
ATOM   4027 C "C4'" . C   C 2 5   ? -15.50200 -8.02200  14.82000  1.000 94.71067  ? 2517 C   C "C4'" 1 
ATOM   4028 O "O4'" . C   C 2 5   ? -16.24400 -7.13900  13.94100  1.000 96.85926  ? 2517 C   C "O4'" 1 
ATOM   4029 C "C3'" . C   C 2 5   ? -14.99300 -7.06300  15.89300  1.000 98.26718  ? 2517 C   C "C3'" 1 
ATOM   4030 O "O3'" . C   C 2 5   ? -13.95900 -7.67700  16.64400  1.000 100.20878 ? 2517 C   C "O3'" 1 
ATOM   4031 C "C2'" . C   C 2 5   ? -14.52500 -5.90300  15.01500  1.000 98.90886  ? 2517 C   C "C2'" 1 
ATOM   4032 O "O2'" . C   C 2 5   ? -13.27100 -6.16400  14.42300  1.000 94.97194  ? 2517 C   C "O2'" 1 
ATOM   4033 C "C1'" . C   C 2 5   ? -15.62900 -5.86600  13.94900  1.000 98.94810  ? 2517 C   C "C1'" 1 
ATOM   4034 N N1    . C   C 2 5   ? -16.66100 -4.82900  14.22800  1.000 103.22004 ? 2517 C   C N1    1 
ATOM   4035 C C2    . C   C 2 5   ? -16.29200 -3.48000  14.20000  1.000 104.99513 ? 2517 C   C C2    1 
ATOM   4036 O O2    . C   C 2 5   ? -15.12400 -3.17900  13.91500  1.000 105.09171 ? 2517 C   C O2    1 
ATOM   4037 N N3    . C   C 2 5   ? -17.22700 -2.53700  14.45800  1.000 105.01544 ? 2517 C   C N3    1 
ATOM   4038 C C4    . C   C 2 5   ? -18.48500 -2.88800  14.74400  1.000 104.80410 ? 2517 C   C C4    1 
ATOM   4039 N N4    . C   C 2 5   ? -19.35500 -1.91900  14.98800  1.000 102.43308 ? 2517 C   C N4    1 
ATOM   4040 C C5    . C   C 2 5   ? -18.87800 -4.25300  14.78400  1.000 102.58105 ? 2517 C   C C5    1 
ATOM   4041 C C6    . C   C 2 5   ? -17.94500 -5.17900  14.52100  1.000 100.97829 ? 2517 C   C C6    1 
ATOM   4042 P P     . A   C 2 6   ? -14.14800 -7.92400  18.21700  1.000 102.93219 ? 2518 A   C P     1 
ATOM   4043 O OP1   . A   C 2 6   ? -13.59500 -9.24800  18.69900  1.000 97.15225  ? 2518 A   C OP1   1 
ATOM   4044 O OP2   . A   C 2 6   ? -15.55000 -7.62200  18.69300  1.000 96.30361  ? 2518 A   C OP2   1 
ATOM   4045 O "O5'" . A   C 2 6   ? -13.20200 -6.77300  18.79300  1.000 103.98083 ? 2518 A   C "O5'" 1 
ATOM   4046 C "C5'" . A   C 2 6   ? -13.76900 -5.45900  18.93700  1.000 105.09233 ? 2518 A   C "C5'" 1 
ATOM   4047 C "C4'" . A   C 2 6   ? -12.79300 -4.43500  18.42100  1.000 107.01146 ? 2518 A   C "C4'" 1 
ATOM   4048 O "O4'" . A   C 2 6   ? -13.23600 -3.96200  17.12400  1.000 106.44898 ? 2518 A   C "O4'" 1 
ATOM   4049 C "C3'" . A   C 2 6   ? -12.66200 -3.18400  19.29600  1.000 111.92828 ? 2518 A   C "C3'" 1 
ATOM   4050 O "O3'" . A   C 2 6   ? -11.51600 -3.30200  20.12500  1.000 110.64807 ? 2518 A   C "O3'" 1 
ATOM   4051 C "C2'" . A   C 2 6   ? -12.56400 -2.05200  18.27300  1.000 111.17096 ? 2518 A   C "C2'" 1 
ATOM   4052 O "O2'" . A   C 2 6   ? -11.24300 -1.85200  17.82200  1.000 109.56504 ? 2518 A   C "O2'" 1 
ATOM   4053 C "C1'" . A   C 2 6   ? -13.48800 -2.57900  17.18200  1.000 109.04163 ? 2518 A   C "C1'" 1 
ATOM   4054 N N9    . A   C 2 6   ? -14.90700 -2.38300  17.45700  1.000 110.05307 ? 2518 A   C N9    1 
ATOM   4055 C C8    . A   C 2 6   ? -15.87000 -3.35600  17.53300  1.000 109.04308 ? 2518 A   C C8    1 
ATOM   4056 N N7    . A   C 2 6   ? -17.06500 -2.89400  17.79200  1.000 109.82001 ? 2518 A   C N7    1 
ATOM   4057 C C5    . A   C 2 6   ? -16.88400 -1.52300  17.87900  1.000 113.06874 ? 2518 A   C C5    1 
ATOM   4058 C C6    . A   C 2 6   ? -17.78100 -0.47200  18.13400  1.000 114.19558 ? 2518 A   C C6    1 
ATOM   4059 N N6    . A   C 2 6   ? -19.08000 -0.64800  18.35400  1.000 113.68510 ? 2518 A   C N6    1 
ATOM   4060 N N1    . A   C 2 6   ? -17.27700 0.78200   18.16400  1.000 116.31887 ? 2518 A   C N1    1 
ATOM   4061 C C2    . A   C 2 6   ? -15.96700 0.95000   17.94800  1.000 116.15496 ? 2518 A   C C2    1 
ATOM   4062 N N3    . A   C 2 6   ? -15.03200 0.04000   17.69700  1.000 114.83228 ? 2518 A   C N3    1 
ATOM   4063 C C4    . A   C 2 6   ? -15.55800 -1.19400  17.67800  1.000 113.11285 ? 2518 A   C C4    1 
ATOM   4064 P P     . U   C 2 7   ? -11.69000 -3.65900  21.67700  1.000 106.33762 ? 2519 U   C P     1 
ATOM   4065 O OP1   . U   C 2 7   ? -10.45200 -4.30200  22.25600  1.000 110.60552 ? 2519 U   C OP1   1 
ATOM   4066 O OP2   . U   C 2 7   ? -12.96800 -4.40900  21.97800  1.000 106.69701 ? 2519 U   C OP2   1 
ATOM   4067 O "O5'" . U   C 2 7   ? -11.84200 -2.19600  22.32700  1.000 115.73879 ? 2519 U   C "O5'" 1 
ATOM   4068 C "C5'" . U   C 2 7   ? -10.99100 -1.13200  21.83600  1.000 116.33249 ? 2519 U   C "C5'" 1 
ATOM   4069 C "C4'" . U   C 2 7   ? -11.75800 0.16600   21.82800  1.000 117.01078 ? 2519 U   C "C4'" 1 
ATOM   4070 O "O4'" . U   C 2 7   ? -12.78400 0.13100   20.80300  1.000 115.18401 ? 2519 U   C "O4'" 1 
ATOM   4071 C "C3'" . U   C 2 7   ? -12.54000 0.49700   23.10300  1.000 121.41877 ? 2519 U   C "C3'" 1 
ATOM   4072 O "O3'" . U   C 2 7   ? -11.69000 1.00400   24.12800  1.000 124.80331 ? 2519 U   C "O3'" 1 
ATOM   4073 C "C2'" . U   C 2 7   ? -13.52600 1.53400   22.56000  1.000 121.25127 ? 2519 U   C "C2'" 1 
ATOM   4074 O "O2'" . U   C 2 7   ? -12.94500 2.80500   22.36000  1.000 120.12317 ? 2519 U   C "O2'" 1 
ATOM   4075 C "C1'" . U   C 2 7   ? -13.87800 0.93200   21.19800  1.000 118.50712 ? 2519 U   C "C1'" 1 
ATOM   4076 N N1    . U   C 2 7   ? -15.09200 0.09400   21.24800  1.000 117.60226 ? 2519 U   C N1    1 
ATOM   4077 C C2    . U   C 2 7   ? -16.30700 0.74200   21.37400  1.000 118.88726 ? 2519 U   C C2    1 
ATOM   4078 O O2    . U   C 2 7   ? -16.41500 1.95900   21.42300  1.000 119.55895 ? 2519 U   C O2    1 
ATOM   4079 N N3    . U   C 2 7   ? -17.39800 -0.08600  21.42600  1.000 117.96772 ? 2519 U   C N3    1 
ATOM   4080 C C4    . U   C 2 7   ? -17.39900 -1.46500  21.37000  1.000 116.14620 ? 2519 U   C C4    1 
ATOM   4081 O O4    . U   C 2 7   ? -18.46900 -2.06900  21.42400  1.000 114.68577 ? 2519 U   C O4    1 
ATOM   4082 C C5    . U   C 2 7   ? -16.10300 -2.06200  21.24200  1.000 114.85951 ? 2519 U   C C5    1 
ATOM   4083 C C6    . U   C 2 7   ? -15.01800 -1.27700  21.18900  1.000 115.68400 ? 2519 U   C C6    1 
ATOM   4084 P P     . C   C 2 8   ? -12.00500 0.78900   25.69200  1.000 126.88773 ? 2520 C   C P     1 
ATOM   4085 O OP1   . C   C 2 8   ? -10.76500 1.00100   26.53100  1.000 130.01335 ? 2520 C   C OP1   1 
ATOM   4086 O OP2   . C   C 2 8   ? -12.68300 -0.54300  25.92600  1.000 122.65335 ? 2520 C   C OP2   1 
ATOM   4087 O "O5'" . C   C 2 8   ? -13.06400 1.93500   26.10800  1.000 128.32466 ? 2520 C   C "O5'" 1 
ATOM   4088 C "C5'" . C   C 2 8   ? -12.74000 3.32400   25.85100  1.000 125.64995 ? 2520 C   C "C5'" 1 
ATOM   4089 C "C4'" . C   C 2 8   ? -14.01500 4.12600   25.77100  1.000 126.49191 ? 2520 C   C "C4'" 1 
ATOM   4090 O "O4'" . C   C 2 8   ? -14.81300 3.67000   24.64600  1.000 125.15791 ? 2520 C   C "O4'" 1 
ATOM   4091 C "C3'" . C   C 2 8   ? -14.97300 3.98800   26.96000  1.000 128.88324 ? 2520 C   C "C3'" 1 
ATOM   4092 O "O3'" . C   C 2 8   ? -14.57900 4.75100   28.10000  1.000 130.09852 ? 2520 C   C "O3'" 1 
ATOM   4093 C "C2'" . C   C 2 8   ? -16.28200 4.45800   26.32400  1.000 127.41203 ? 2520 C   C "C2'" 1 
ATOM   4094 O "O2'" . C   C 2 8   ? -16.32600 5.85800   26.15700  1.000 126.79958 ? 2520 C   C "O2'" 1 
ATOM   4095 C "C1'" . C   C 2 8   ? -16.18900 3.78400   24.95100  1.000 126.30097 ? 2520 C   C "C1'" 1 
ATOM   4096 N N1    . C   C 2 8   ? -16.80500 2.43000   24.92400  1.000 124.89138 ? 2520 C   C N1    1 
ATOM   4097 C C2    . C   C 2 8   ? -18.19900 2.32000   24.88500  1.000 125.03706 ? 2520 C   C C2    1 
ATOM   4098 O O2    . C   C 2 8   ? -18.89200 3.34800   24.86600  1.000 125.83043 ? 2520 C   C O2    1 
ATOM   4099 N N3    . C   C 2 8   ? -18.75700 1.08900   24.86000  1.000 124.18936 ? 2520 C   C N3    1 
ATOM   4100 C C4    . C   C 2 8   ? -17.99200 -0.00700  24.87400  1.000 123.15299 ? 2520 C   C C4    1 
ATOM   4101 N N4    . C   C 2 8   ? -18.60100 -1.18300  24.85000  1.000 122.98253 ? 2520 C   C N4    1 
ATOM   4102 C C5    . C   C 2 8   ? -16.57600 0.08200   24.91600  1.000 122.46432 ? 2520 C   C C5    1 
ATOM   4103 C C6    . C   C 2 8   ? -16.03200 1.30700   24.93800  1.000 123.31679 ? 2520 C   C C6    1 
ATOM   4104 P P     . C   C 2 9   ? -14.42900 4.08400   29.55900  1.000 130.23443 ? 2521 C   C P     1 
ATOM   4105 O OP1   . C   C 2 9   ? -13.29400 4.73400   30.26900  1.000 129.72669 ? 2521 C   C OP1   1 
ATOM   4106 O OP2   . C   C 2 9   ? -14.46900 2.60400   29.43800  1.000 127.35177 ? 2521 C   C OP2   1 
ATOM   4107 O "O5'" . C   C 2 9   ? -15.79400 4.53500   30.25400  1.000 129.14948 ? 2521 C   C "O5'" 1 
ATOM   4108 C "C5'" . C   C 2 9   ? -16.97200 3.74500   30.14600  1.000 128.29311 ? 2521 C   C "C5'" 1 
ATOM   4109 C "C4'" . C   C 2 9   ? -18.17000 4.57900   29.75500  1.000 127.29119 ? 2521 C   C "C4'" 1 
ATOM   4110 O "O4'" . C   C 2 9   ? -18.76100 4.04300   28.54200  1.000 129.42123 ? 2521 C   C "O4'" 1 
ATOM   4111 C "C3'" . C   C 2 9   ? -19.32800 4.60700   30.74400  1.000 128.00551 ? 2521 C   C "C3'" 1 
ATOM   4112 O "O3'" . C   C 2 9   ? -19.12900 5.50600   31.82500  1.000 126.77944 ? 2521 C   C "O3'" 1 
ATOM   4113 C "C2'" . C   C 2 9   ? -20.51000 4.96700   29.85300  1.000 128.14760 ? 2521 C   C "C2'" 1 
ATOM   4114 O "O2'" . C   C 2 9   ? -20.50100 6.35200   29.53900  1.000 127.00017 ? 2521 C   C "O2'" 1 
ATOM   4115 C "C1'" . C   C 2 9   ? -20.16500 4.19200   28.58400  1.000 130.30996 ? 2521 C   C "C1'" 1 
ATOM   4116 P P     . U   C 2 10  ? -19.18800 4.97600   33.34700  1.000 123.81335 ? 2522 U   C P     1 
ATOM   4117 O OP1   . U   C 2 10  ? -19.27600 6.18700   34.20400  1.000 103.85335 ? 2522 U   C OP1   1 
ATOM   4118 O OP2   . U   C 2 10  ? -18.01800 4.07900   33.53400  1.000 118.55335 ? 2522 U   C OP2   1 
ATOM   4119 O "O5'" . U   C 2 10  ? -20.54400 4.13200   33.40700  1.000 117.82335 ? 2522 U   C "O5'" 1 
ATOM   4120 P P     . G   C 2 31  ? -26.93800 -3.21800  22.88600  1.000 153.45842 ? 2543 G   C P     1 
ATOM   4121 O OP1   . G   C 2 31  ? -28.29500 -3.83800  22.62100  1.000 152.30335 ? 2543 G   C OP1   1 
ATOM   4122 O OP2   . G   C 2 31  ? -26.89400 -1.73300  22.58700  1.000 148.02315 ? 2543 G   C OP2   1 
ATOM   4123 O "O5'" . G   C 2 31  ? -26.68000 -3.36000  24.47100  1.000 149.54642 ? 2543 G   C "O5'" 1 
ATOM   4124 C "C5'" . G   C 2 31  ? -27.68500 -4.00300  25.29200  1.000 147.36374 ? 2543 G   C "C5'" 1 
ATOM   4125 C "C4'" . G   C 2 31  ? -27.81300 -3.24400  26.58700  1.000 145.84253 ? 2543 G   C "C4'" 1 
ATOM   4126 O "O4'" . G   C 2 31  ? -26.56700 -3.35600  27.31800  1.000 144.88571 ? 2543 G   C "O4'" 1 
ATOM   4127 C "C3'" . G   C 2 31  ? -28.03600 -1.73600  26.45400  1.000 146.49585 ? 2543 G   C "C3'" 1 
ATOM   4128 O "O3'" . G   C 2 31  ? -29.41300 -1.39600  26.31200  1.000 146.77075 ? 2543 G   C "O3'" 1 
ATOM   4129 C "C2'" . G   C 2 31  ? -27.45900 -1.20100  27.76700  1.000 145.13324 ? 2543 G   C "C2'" 1 
ATOM   4130 O "O2'" . G   C 2 31  ? -28.42000 -1.17100  28.79900  1.000 144.42412 ? 2543 G   C "O2'" 1 
ATOM   4131 C "C1'" . G   C 2 31  ? -26.33800 -2.19200  28.08300  1.000 143.60966 ? 2543 G   C "C1'" 1 
ATOM   4132 N N9    . G   C 2 31  ? -24.99000 -1.71500  27.79100  1.000 141.06365 ? 2543 G   C N9    1 
ATOM   4133 C C8    . G   C 2 31  ? -24.01500 -2.42000  27.13300  1.000 139.62664 ? 2543 G   C C8    1 
ATOM   4134 N N7    . G   C 2 31  ? -22.88400 -1.76700  27.02100  1.000 137.97342 ? 2543 G   C N7    1 
ATOM   4135 C C5    . G   C 2 31  ? -23.12500 -0.55800  27.66000  1.000 138.24073 ? 2543 G   C C5    1 
ATOM   4136 C C6    . G   C 2 31  ? -22.26700 0.55300   27.85300  1.000 136.34133 ? 2543 G   C C6    1 
ATOM   4137 O O6    . G   C 2 31  ? -21.09100 0.68800   27.48800  1.000 132.10501 ? 2543 G   C O6    1 
ATOM   4138 N N1    . G   C 2 31  ? -22.90900 1.57900   28.54500  1.000 138.40434 ? 2543 G   C N1    1 
ATOM   4139 C C2    . G   C 2 31  ? -24.20500 1.53800   28.99500  1.000 139.97142 ? 2543 G   C C2    1 
ATOM   4140 N N2    . G   C 2 31  ? -24.64800 2.62200   29.64600  1.000 138.54980 ? 2543 G   C N2    1 
ATOM   4141 N N3    . G   C 2 31  ? -25.01500 0.49600   28.81700  1.000 141.18077 ? 2543 G   C N3    1 
ATOM   4142 C C4    . G   C 2 31  ? -24.41500 -0.51300  28.14200  1.000 140.45398 ? 2543 G   C C4    1 
ATOM   4143 P P     . G   C 2 32  ? -30.07200 -1.04800  24.88500  1.000 149.05234 ? 2544 G   C P     1 
ATOM   4144 O OP1   . G   C 2 32  ? -31.23900 -0.09300  24.99700  1.000 146.30770 ? 2544 G   C OP1   1 
ATOM   4145 O OP2   . G   C 2 32  ? -30.41700 -2.31200  24.12500  1.000 147.64155 ? 2544 G   C OP2   1 
ATOM   4146 O "O5'" . G   C 2 32  ? -28.92700 -0.28000  24.02900  1.000 147.57297 ? 2544 G   C "O5'" 1 
ATOM   4147 C "C5'" . G   C 2 32  ? -29.16100 1.08600   23.59900  1.000 144.02289 ? 2544 G   C "C5'" 1 
ATOM   4148 C "C4'" . G   C 2 32  ? -28.48400 2.05700   24.53800  1.000 142.21150 ? 2544 G   C "C4'" 1 
ATOM   4149 O "O4'" . G   C 2 32  ? -27.68800 1.33800   25.51300  1.000 142.61963 ? 2544 G   C "O4'" 1 
ATOM   4150 C "C3'" . G   C 2 32  ? -27.49500 3.03600   23.90000  1.000 139.97513 ? 2544 G   C "C3'" 1 
ATOM   4151 O "O3'" . G   C 2 32  ? -28.15400 4.17700   23.37200  1.000 139.22604 ? 2544 G   C "O3'" 1 
ATOM   4152 C "C2'" . G   C 2 32  ? -26.61700 3.39400   25.09700  1.000 138.88365 ? 2544 G   C "C2'" 1 
ATOM   4153 O "O2'" . G   C 2 32  ? -27.22200 4.33300   25.95800  1.000 136.10101 ? 2544 G   C "O2'" 1 
ATOM   4154 C "C1'" . G   C 2 32  ? -26.48400 2.03000   25.76400  1.000 140.71315 ? 2544 G   C "C1'" 1 
ATOM   4155 N N9    . G   C 2 32  ? -25.37700 1.22900   25.25500  1.000 138.71330 ? 2544 G   C N9    1 
ATOM   4156 C C8    . G   C 2 32  ? -25.44800 -0.05800  24.78900  1.000 139.50951 ? 2544 G   C C8    1 
ATOM   4157 N N7    . G   C 2 32  ? -24.29000 -0.53200  24.40000  1.000 137.63025 ? 2544 G   C N7    1 
ATOM   4158 C C5    . G   C 2 32  ? -23.40200 0.51200   24.62300  1.000 136.00988 ? 2544 G   C C5    1 
ATOM   4159 C C6    . G   C 2 32  ? -22.00600 0.58000   24.39800  1.000 132.31646 ? 2544 G   C C6    1 
ATOM   4160 O O6    . G   C 2 32  ? -21.26500 -0.29600  23.93200  1.000 128.77699 ? 2544 G   C O6    1 
ATOM   4161 N N1    . G   C 2 32  ? -21.48800 1.82300   24.76800  1.000 131.34912 ? 2544 G   C N1    1 
ATOM   4162 C C2    . G   C 2 32  ? -22.22200 2.85900   25.28700  1.000 132.25116 ? 2544 G   C C2    1 
ATOM   4163 N N2    . G   C 2 32  ? -21.55400 3.98100   25.58000  1.000 130.17470 ? 2544 G   C N2    1 
ATOM   4164 N N3    . G   C 2 32  ? -23.53300 2.79800   25.50500  1.000 135.08750 ? 2544 G   C N3    1 
ATOM   4165 C C4    . G   C 2 32  ? -24.05700 1.60000   25.15300  1.000 136.91877 ? 2544 G   C C4    1 
ATOM   4166 P P     . G   C 2 33  ? -28.19600 4.41200   21.78600  1.000 138.98724 ? 2545 G   C P     1 
ATOM   4167 O OP1   . G   C 2 33  ? -29.56000 4.81700   21.27200  1.000 138.09004 ? 2545 G   C OP1   1 
ATOM   4168 O OP2   . G   C 2 33  ? -27.58000 3.25000   21.03600  1.000 136.01074 ? 2545 G   C OP2   1 
ATOM   4169 O "O5'" . G   C 2 33  ? -27.20200 5.66500   21.62200  1.000 133.48958 ? 2545 G   C "O5'" 1 
ATOM   4170 C "C5'" . G   C 2 33  ? -25.88900 5.42000   21.07500  1.000 130.32854 ? 2545 G   C "C5'" 1 
ATOM   4171 C "C4'" . G   C 2 33  ? -24.90200 6.38900   21.67500  1.000 127.66426 ? 2545 G   C "C4'" 1 
ATOM   4172 O "O4'" . G   C 2 33  ? -24.26800 5.77300   22.82500  1.000 128.67250 ? 2545 G   C "O4'" 1 
ATOM   4173 C "C3'" . G   C 2 33  ? -23.76500 6.81300   20.74000  1.000 124.76603 ? 2545 G   C "C3'" 1 
ATOM   4174 O "O3'" . G   C 2 33  ? -24.06800 8.07700   20.17000  1.000 123.79398 ? 2545 G   C "O3'" 1 
ATOM   4175 C "C2'" . G   C 2 33  ? -22.54300 6.88100   21.65900  1.000 124.14947 ? 2545 G   C "C2'" 1 
ATOM   4176 O "O2'" . G   C 2 33  ? -22.36400 8.15600   22.23500  1.000 122.30764 ? 2545 G   C "O2'" 1 
ATOM   4177 C "C1'" . G   C 2 33  ? -22.86600 5.80300   22.69100  1.000 127.77183 ? 2545 G   C "C1'" 1 
ATOM   4178 N N9    . G   C 2 33  ? -22.41200 4.47700   22.29600  1.000 127.39583 ? 2545 G   C N9    1 
ATOM   4179 C C8    . G   C 2 33  ? -23.19300 3.37500   22.06300  1.000 127.97555 ? 2545 G   C C8    1 
ATOM   4180 N N7    . G   C 2 33  ? -22.50700 2.32000   21.70400  1.000 126.82093 ? 2545 G   C N7    1 
ATOM   4181 C C5    . G   C 2 33  ? -21.19000 2.75800   21.70000  1.000 124.96221 ? 2545 G   C C5    1 
ATOM   4182 C C6    . G   C 2 33  ? -20.00400 2.05400   21.39200  1.000 122.59273 ? 2545 G   C C6    1 
ATOM   4183 O O6    . G   C 2 33  ? -19.88900 0.87100   21.04900  1.000 121.67410 ? 2545 G   C O6    1 
ATOM   4184 N N1    . G   C 2 33  ? -18.88300 2.87400   21.50300  1.000 121.90013 ? 2545 G   C N1    1 
ATOM   4185 C C2    . G   C 2 33  ? -18.89900 4.19600   21.87200  1.000 121.57131 ? 2545 G   C C2    1 
ATOM   4186 N N2    . G   C 2 33  ? -17.71600 4.81900   21.93000  1.000 117.54803 ? 2545 G   C N2    1 
ATOM   4187 N N3    . G   C 2 33  ? -20.01300 4.86300   22.16500  1.000 123.33722 ? 2545 G   C N3    1 
ATOM   4188 C C4    . G   C 2 33  ? -21.11600 4.08500   22.06000  1.000 125.75647 ? 2545 G   C C4    1 
ATOM   4189 P P     . U   C 2 34  ? -24.08600 8.30600   18.57900  1.000 117.45033 ? 2546 U   C P     1 
ATOM   4190 O OP1   . U   C 2 34  ? -24.88600 9.52400   18.17400  1.000 111.18429 ? 2546 U   C OP1   1 
ATOM   4191 O OP2   . U   C 2 34  ? -24.39700 7.07700   17.74800  1.000 117.20221 ? 2546 U   C OP2   1 
ATOM   4192 O "O5'" . U   C 2 34  ? -22.54600 8.66500   18.31900  1.000 114.53149 ? 2546 U   C "O5'" 1 
ATOM   4193 C "C5'" . U   C 2 34  ? -21.73300 7.68000   17.65900  1.000 116.14595 ? 2546 U   C "C5'" 1 
ATOM   4194 C "C4'" . U   C 2 34  ? -20.29300 7.86300   18.06400  1.000 115.53204 ? 2546 U   C "C4'" 1 
ATOM   4195 O "O4'" . U   C 2 34  ? -19.99900 7.00800   19.19900  1.000 117.99381 ? 2546 U   C "O4'" 1 
ATOM   4196 C "C3'" . U   C 2 34  ? -19.27800 7.50500   16.97000  1.000 115.02601 ? 2546 U   C "C3'" 1 
ATOM   4197 O "O3'" . U   C 2 34  ? -18.75200 8.69800   16.40500  1.000 114.17491 ? 2546 U   C "O3'" 1 
ATOM   4198 C "C2'" . U   C 2 34  ? -18.20700 6.68700   17.69700  1.000 116.33244 ? 2546 U   C "C2'" 1 
ATOM   4199 O "O2'" . U   C 2 34  ? -17.15800 7.48700   18.19800  1.000 116.26614 ? 2546 U   C "O2'" 1 
ATOM   4200 C "C1'" . U   C 2 34  ? -18.97800 6.09000   18.87500  1.000 118.56514 ? 2546 U   C "C1'" 1 
ATOM   4201 N N1    . U   C 2 34  ? -19.58600 4.76800   18.59600  1.000 119.37229 ? 2546 U   C N1    1 
ATOM   4202 C C2    . U   C 2 34  ? -18.73200 3.70800   18.34700  1.000 118.89941 ? 2546 U   C C2    1 
ATOM   4203 O O2    . U   C 2 34  ? -17.51300 3.81000   18.33800  1.000 117.82698 ? 2546 U   C O2    1 
ATOM   4204 N N3    . U   C 2 34  ? -19.35600 2.51300   18.10600  1.000 118.05352 ? 2546 U   C N3    1 
ATOM   4205 C C4    . U   C 2 34  ? -20.71300 2.26600   18.09300  1.000 119.06649 ? 2546 U   C C4    1 
ATOM   4206 O O4    . U   C 2 34  ? -21.11500 1.12800   17.86200  1.000 119.84796 ? 2546 U   C O4    1 
ATOM   4207 C C5    . U   C 2 34  ? -21.53200 3.40900   18.36700  1.000 118.37818 ? 2546 U   C C5    1 
ATOM   4208 C C6    . U   C 2 34  ? -20.94900 4.58900   18.61300  1.000 118.57082 ? 2546 U   C C6    1 
ATOM   4209 P P     . U   C 2 35  ? -19.50800 9.44400   15.20200  1.000 114.35785 ? 2547 U   C P     1 
ATOM   4210 O OP1   . U   C 2 35  ? -20.42100 8.51000   14.44000  1.000 111.86905 ? 2547 U   C OP1   1 
ATOM   4211 O OP2   . U   C 2 35  ? -18.54800 10.21400  14.32200  1.000 109.80127 ? 2547 U   C OP2   1 
ATOM   4212 O "O5'" . U   C 2 35  ? -20.44600 10.53100  15.92600  1.000 104.33186 ? 2547 U   C "O5'" 1 
ATOM   4213 C "C5'" . U   C 2 35  ? -21.80200 10.70500  15.44500  1.000 100.01465 ? 2547 U   C "C5'" 1 
ATOM   4214 C "C4'" . U   C 2 35  ? -22.57700 11.56000  16.41700  1.000 95.21763  ? 2547 U   C "C4'" 1 
ATOM   4215 O "O4'" . U   C 2 35  ? -21.66900 12.15100  17.38200  1.000 92.22281  ? 2547 U   C "O4'" 1 
ATOM   4216 C "C3'" . U   C 2 35  ? -23.32400 12.74800  15.79900  1.000 90.64034  ? 2547 U   C "C3'" 1 
ATOM   4217 O "O3'" . U   C 2 35  ? -24.62500 12.35500  15.38600  1.000 90.45036  ? 2547 U   C "O3'" 1 
ATOM   4218 C "C2'" . U   C 2 35  ? -23.36300 13.74500  16.95900  1.000 85.99686  ? 2547 U   C "C2'" 1 
ATOM   4219 O "O2'" . U   C 2 35  ? -24.38400 13.45400  17.88800  1.000 84.53189  ? 2547 U   C "O2'" 1 
ATOM   4220 C "C1'" . U   C 2 35  ? -22.00500 13.50100  17.61700  1.000 86.86218  ? 2547 U   C "C1'" 1 
ATOM   4221 N N1    . U   C 2 35  ? -20.92500 14.35700  17.08200  1.000 83.39517  ? 2547 U   C N1    1 
ATOM   4222 C C2    . U   C 2 35  ? -20.88200 15.67300  17.50400  1.000 78.07624  ? 2547 U   C C2    1 
ATOM   4223 O O2    . U   C 2 35  ? -21.69600 16.15500  18.27800  1.000 78.89864  ? 2547 U   C O2    1 
ATOM   4224 N N3    . U   C 2 35  ? -19.85000 16.41000  16.98500  1.000 77.81920  ? 2547 U   C N3    1 
ATOM   4225 C C4    . U   C 2 35  ? -18.87400 15.97900  16.11200  1.000 79.65903  ? 2547 U   C C4    1 
ATOM   4226 O O4    . U   C 2 35  ? -18.01300 16.76800  15.72800  1.000 78.57022  ? 2547 U   C O4    1 
ATOM   4227 C C5    . U   C 2 35  ? -18.97800 14.60200  15.73100  1.000 85.57312  ? 2547 U   C C5    1 
ATOM   4228 C C6    . U   C 2 35  ? -19.97700 13.85600  16.22200  1.000 85.56878  ? 2547 U   C C6    1 
ATOM   4229 P P     . G   C 2 36  ? -25.20100 12.80000  13.95600  1.000 91.20256  ? 2548 G   C P     1 
ATOM   4230 O OP1   . G   C 2 36  ? -26.12400 11.77200  13.34900  1.000 92.59167  ? 2548 G   C OP1   1 
ATOM   4231 O OP2   . G   C 2 36  ? -24.12700 13.29700  13.01900  1.000 82.22234  ? 2548 G   C OP2   1 
ATOM   4232 O "O5'" . G   C 2 36  ? -26.10600 14.06100  14.35900  1.000 83.17570  ? 2548 G   C "O5'" 1 
ATOM   4233 C "C5'" . G   C 2 36  ? -25.53900 15.37300  14.19200  1.000 81.90123  ? 2548 G   C "C5'" 1 
ATOM   4234 C "C4'" . G   C 2 36  ? -26.12800 16.32100  15.20400  1.000 76.98302  ? 2548 G   C "C4'" 1 
ATOM   4235 O "O4'" . G   C 2 36  ? -25.19100 16.48700  16.29600  1.000 79.58282  ? 2548 G   C "O4'" 1 
ATOM   4236 C "C3'" . G   C 2 36  ? -26.40700 17.73100  14.67100  1.000 73.25677  ? 2548 G   C "C3'" 1 
ATOM   4237 O "O3'" . G   C 2 36  ? -27.79000 17.86500  14.36500  1.000 75.51378  ? 2548 G   C "O3'" 1 
ATOM   4238 C "C2'" . G   C 2 36  ? -25.93100 18.65500  15.79400  1.000 71.73850  ? 2548 G   C "C2'" 1 
ATOM   4239 O "O2'" . G   C 2 36  ? -26.94600 18.94300  16.72800  1.000 75.99122  ? 2548 G   C "O2'" 1 
ATOM   4240 C "C1'" . G   C 2 36  ? -24.79400 17.83500  16.39400  1.000 75.01370  ? 2548 G   C "C1'" 1 
ATOM   4241 N N9    . G   C 2 36  ? -23.51600 18.00000  15.71000  1.000 71.47426  ? 2548 G   C N9    1 
ATOM   4242 C C8    . G   C 2 36  ? -22.78600 17.02900  15.07200  1.000 70.50653  ? 2548 G   C C8    1 
ATOM   4243 N N7    . G   C 2 36  ? -21.67100 17.47400  14.55200  1.000 66.29058  ? 2548 G   C N7    1 
ATOM   4244 C C5    . G   C 2 36  ? -21.66200 18.82300  14.87500  1.000 63.87140  ? 2548 G   C C5    1 
ATOM   4245 C C6    . G   C 2 36  ? -20.70200 19.81800  14.58000  1.000 57.87875  ? 2548 G   C C6    1 
ATOM   4246 O O6    . G   C 2 36  ? -19.63900 19.69000  13.96200  1.000 55.80388  ? 2548 G   C O6    1 
ATOM   4247 N N1    . G   C 2 36  ? -21.07900 21.05800  15.09100  1.000 55.34605  ? 2548 G   C N1    1 
ATOM   4248 C C2    . G   C 2 36  ? -22.23500 21.30700  15.78700  1.000 60.13237  ? 2548 G   C C2    1 
ATOM   4249 N N2    . G   C 2 36  ? -22.43100 22.56400  16.20300  1.000 58.85399  ? 2548 G   C N2    1 
ATOM   4250 N N3    . G   C 2 36  ? -23.13900 20.37400  16.07200  1.000 63.93946  ? 2548 G   C N3    1 
ATOM   4251 C C4    . G   C 2 36  ? -22.79100 19.16000  15.58500  1.000 64.66216  ? 2548 G   C C4    1 
ATOM   4252 P P     . G   C 2 37  ? -28.31700 17.72400  12.85200  1.000 83.71139  ? 2549 G   C P     1 
ATOM   4253 O OP1   . G   C 2 37  ? -29.73200 17.19700  12.78000  1.000 83.35754  ? 2549 G   C OP1   1 
ATOM   4254 O OP2   . G   C 2 37  ? -27.34200 17.02700  11.93300  1.000 71.88510  ? 2549 G   C OP2   1 
ATOM   4255 O "O5'" . G   C 2 37  ? -28.36000 19.25500  12.39000  1.000 78.45121  ? 2549 G   C "O5'" 1 
ATOM   4256 C "C5'" . G   C 2 37  ? -27.14600 19.85100  11.89100  1.000 67.48119  ? 2549 G   C "C5'" 1 
ATOM   4257 C "C4'" . G   C 2 37  ? -26.98200 21.20700  12.52300  1.000 63.97545  ? 2549 G   C "C4'" 1 
ATOM   4258 O "O4'" . G   C 2 37  ? -25.95800 21.14200  13.54900  1.000 66.16880  ? 2549 G   C "O4'" 1 
ATOM   4259 C "C3'" . G   C 2 37  ? -26.52500 22.31700  11.57400  1.000 58.88714  ? 2549 G   C "C3'" 1 
ATOM   4260 O "O3'" . G   C 2 37  ? -27.64700 22.92100  10.94800  1.000 61.11998  ? 2549 G   C "O3'" 1 
ATOM   4261 C "C2'" . G   C 2 37  ? -25.75400 23.23500  12.52300  1.000 54.97394  ? 2549 G   C "C2'" 1 
ATOM   4262 O "O2'" . G   C 2 37  ? -26.58500 24.07600  13.29000  1.000 54.27771  ? 2549 G   C "O2'" 1 
ATOM   4263 C "C1'" . G   C 2 37  ? -25.03800 22.19500  13.37600  1.000 59.90353  ? 2549 G   C "C1'" 1 
ATOM   4264 N N9    . G   C 2 37  ? -23.84100 21.66200  12.74200  1.000 53.06393  ? 2549 G   C N9    1 
ATOM   4265 C C8    . G   C 2 37  ? -23.62100 20.37300  12.33000  1.000 55.35179  ? 2549 G   C C8    1 
ATOM   4266 N N7    . G   C 2 37  ? -22.44900 20.20100  11.77500  1.000 54.92252  ? 2549 G   C N7    1 
ATOM   4267 C C5    . G   C 2 37  ? -21.86200 21.45700  11.82300  1.000 51.34105  ? 2549 G   C C5    1 
ATOM   4268 C C6    . G   C 2 37  ? -20.58900 21.88300  11.37700  1.000 47.80170  ? 2549 G   C C6    1 
ATOM   4269 O O6    . G   C 2 37  ? -19.71000 21.20600  10.83100  1.000 46.21930  ? 2549 G   C O6    1 
ATOM   4270 N N1    . G   C 2 37  ? -20.39200 23.24100  11.62500  1.000 44.86140  ? 2549 G   C N1    1 
ATOM   4271 C C2    . G   C 2 37  ? -21.30100 24.07600  12.22400  1.000 48.24638  ? 2549 G   C C2    1 
ATOM   4272 N N2    . G   C 2 37  ? -20.94000 25.35400  12.38100  1.000 45.42858  ? 2549 G   C N2    1 
ATOM   4273 N N3    . G   C 2 37  ? -22.49600 23.67900  12.65000  1.000 53.33831  ? 2549 G   C N3    1 
ATOM   4274 C C4    . G   C 2 37  ? -22.70800 22.36400  12.41800  1.000 52.71680  ? 2549 G   C C4    1 
ATOM   4275 P P     . G   C 2 38  ? -27.71300 23.08500  9.35000   1.000 60.95951  ? 2550 G   C P     1 
ATOM   4276 O OP1   . G   C 2 38  ? -29.07600 23.55600  8.91100   1.000 58.11976  ? 2550 G   C OP1   1 
ATOM   4277 O OP2   . G   C 2 38  ? -27.18200 21.92700  8.54200   1.000 55.73934  ? 2550 G   C OP2   1 
ATOM   4278 O "O5'" . G   C 2 38  ? -26.71200 24.31200  9.10200   1.000 52.88946  ? 2550 G   C "O5'" 1 
ATOM   4279 C "C5'" . G   C 2 38  ? -26.96700 25.54500  9.80400   1.000 49.26776  ? 2550 G   C "C5'" 1 
ATOM   4280 C "C4'" . G   C 2 38  ? -25.71700 26.38300  9.79100   1.000 45.87682  ? 2550 G   C "C4'" 1 
ATOM   4281 O "O4'" . G   C 2 38  ? -24.64800 25.67700  10.46700  1.000 44.23975  ? 2550 G   C "O4'" 1 
ATOM   4282 C "C3'" . G   C 2 38  ? -25.11900 26.68100  8.41500   1.000 43.74505  ? 2550 G   C "C3'" 1 
ATOM   4283 O "O3'" . G   C 2 38  ? -25.81900 27.71300  7.73300   1.000 44.76152  ? 2550 G   C "O3'" 1 
ATOM   4284 C "C2'" . G   C 2 38  ? -23.71700 27.10300  8.84300   1.000 41.72809  ? 2550 G   C "C2'" 1 
ATOM   4285 O "O2'" . G   C 2 38  ? -23.71100 28.39600  9.39800   1.000 39.65207  ? 2550 G   C "O2'" 1 
ATOM   4286 C "C1'" . G   C 2 38  ? -23.41300 26.03900  9.89300   1.000 43.52924  ? 2550 G   C "C1'" 1 
ATOM   4287 N N9    . G   C 2 38  ? -22.77600 24.85800  9.32800   1.000 42.94217  ? 2550 G   C N9    1 
ATOM   4288 C C8    . G   C 2 38  ? -23.27600 23.58600  9.24500   1.000 43.45651  ? 2550 G   C C8    1 
ATOM   4289 N N7    . G   C 2 38  ? -22.45400 22.74700  8.66400   1.000 44.69045  ? 2550 G   C N7    1 
ATOM   4290 C C5    . G   C 2 38  ? -21.34700 23.51800  8.34000   1.000 42.78377  ? 2550 G   C C5    1 
ATOM   4291 C C6    . G   C 2 38  ? -20.13600 23.16000  7.69600   1.000 40.79200  ? 2550 G   C C6    1 
ATOM   4292 O O6    . G   C 2 38  ? -19.79100 22.05400  7.26500   1.000 38.48082  ? 2550 G   C O6    1 
ATOM   4293 N N1    . G   C 2 38  ? -19.28800 24.25900  7.56100   1.000 39.55801  ? 2550 G   C N1    1 
ATOM   4294 C C2    . G   C 2 38  ? -19.56500 25.53100  7.99600   1.000 39.30301  ? 2550 G   C C2    1 
ATOM   4295 N N2    . G   C 2 38  ? -18.62800 26.46200  7.78800   1.000 36.44309  ? 2550 G   C N2    1 
ATOM   4296 N N3    . G   C 2 38  ? -20.69500 25.86900  8.60600   1.000 41.61492  ? 2550 G   C N3    1 
ATOM   4297 C C4    . G   C 2 38  ? -21.53700 24.82000  8.73900   1.000 43.28944  ? 2550 G   C C4    1 
ATOM   4298 P P     . C   C 2 39  ? -25.87100 27.78300  6.12800   1.000 39.28208  ? 2551 C   C P     1 
ATOM   4299 O OP1   . C   C 2 39  ? -26.78100 28.89000  5.67800   1.000 43.34535  ? 2551 C   C OP1   1 
ATOM   4300 O OP2   . C   C 2 39  ? -26.18600 26.44800  5.52100   1.000 36.09671  ? 2551 C   C OP2   1 
ATOM   4301 O "O5'" . C   C 2 39  ? -24.38400 28.14900  5.63700   1.000 37.33300  ? 2551 C   C "O5'" 1 
ATOM   4302 C "C5'" . C   C 2 39  ? -23.71300 29.30500  6.18100   1.000 36.31427  ? 2551 C   C "C5'" 1 
ATOM   4303 C "C4'" . C   C 2 39  ? -22.31400 29.35300  5.62200   1.000 38.85469  ? 2551 C   C "C4'" 1 
ATOM   4304 O "O4'" . C   C 2 39  ? -21.52900 28.25600  6.14800   1.000 39.04091  ? 2551 C   C "O4'" 1 
ATOM   4305 C "C3'" . C   C 2 39  ? -22.21400 29.15800  4.10800   1.000 34.51851  ? 2551 C   C "C3'" 1 
ATOM   4306 O "O3'" . C   C 2 39  ? -22.53200 30.34900  3.40000   1.000 33.71039  ? 2551 C   C "O3'" 1 
ATOM   4307 C "C2'" . C   C 2 39  ? -20.75100 28.73000  3.95200   1.000 30.41544  ? 2551 C   C "C2'" 1 
ATOM   4308 O "O2'" . C   C 2 39  ? -19.83300 29.79700  4.00700   1.000 28.77307  ? 2551 C   C "O2'" 1 
ATOM   4309 C "C1'" . C   C 2 39  ? -20.55900 27.86300  5.20000   1.000 35.07193  ? 2551 C   C "C1'" 1 
ATOM   4310 N N1    . C   C 2 39  ? -20.70700 26.41200  4.90800   1.000 34.31508  ? 2551 C   C N1    1 
ATOM   4311 C C2    . C   C 2 39  ? -19.64200 25.75200  4.29100   1.000 36.50565  ? 2551 C   C C2    1 
ATOM   4312 O O2    . C   C 2 39  ? -18.61700 26.39300  4.01300   1.000 32.97387  ? 2551 C   C O2    1 
ATOM   4313 N N3    . C   C 2 39  ? -19.76000 24.43300  4.01600   1.000 35.07767  ? 2551 C   C N3    1 
ATOM   4314 C C4    . C   C 2 39  ? -20.87900 23.77200  4.33000   1.000 38.95512  ? 2551 C   C C4    1 
ATOM   4315 N N4    . C   C 2 39  ? -20.93500 22.48200  4.03800   1.000 33.27403  ? 2551 C   C N4    1 
ATOM   4316 C C5    . C   C 2 39  ? -21.97400 24.42800  4.95400   1.000 33.70773  ? 2551 C   C C5    1 
ATOM   4317 C C6    . C   C 2 39  ? -21.84700 25.73500  5.22200   1.000 38.22144  ? 2551 C   C C6    1 
ATOM   4318 P P     . U   C 2 40  ? -22.68500 30.35800  1.80100   1.000 35.04472  ? 2552 U   C P     1 
ATOM   4319 O OP1   . U   C 2 40  ? -23.42300 31.58100  1.35200   1.000 42.01889  ? 2552 U   C OP1   1 
ATOM   4320 O OP2   . U   C 2 40  ? -23.17100 29.07700  1.17400   1.000 36.09139  ? 2552 U   C OP2   1 
ATOM   4321 O "O5'" . U   C 2 40  ? -21.17800 30.53200  1.30000   1.000 34.05374  ? 2552 U   C "O5'" 1 
ATOM   4322 C "C5'" . U   C 2 40  ? -20.57300 31.82200  1.44700   1.000 33.66611  ? 2552 U   C "C5'" 1 
ATOM   4323 C "C4'" . U   C 2 40  ? -20.03900 32.26300  0.11100   1.000 36.56535  ? 2552 U   C "C4'" 1 
ATOM   4324 O "O4'" . U   C 2 40  ? -21.14100 32.58800  -0.77600  1.000 33.14290  ? 2552 U   C "O4'" 1 
ATOM   4325 C "C3'" . U   C 2 40  ? -19.17300 33.52500  0.16600   1.000 30.66485  ? 2552 U   C "C3'" 1 
ATOM   4326 O "O3'" . U   C 2 40  ? -18.17700 33.51100  -0.84400  1.000 25.62091  ? 2552 U   C "O3'" 1 
ATOM   4327 C "C2'" . U   C 2 40  ? -20.21200 34.62900  -0.02900  1.000 32.83310  ? 2552 U   C "C2'" 1 
ATOM   4328 O "O2'" . U   C 2 40  ? -19.70800 35.81700  -0.59500  1.000 37.73179  ? 2552 U   C "O2'" 1 
ATOM   4329 C "C1'" . U   C 2 40  ? -21.14000 33.97200  -1.04500  1.000 37.40805  ? 2552 U   C "C1'" 1 
ATOM   4330 N N1    . U   C 2 40  ? -22.50000 34.50500  -0.90700  1.000 44.49892  ? 2552 U   C N1    1 
ATOM   4331 C C2    . U   C 2 40  ? -23.15800 34.85900  -2.06600  1.000 40.91576  ? 2552 U   C C2    1 
ATOM   4332 O O2    . U   C 2 40  ? -22.67700 34.69200  -3.17600  1.000 37.15132  ? 2552 U   C O2    1 
ATOM   4333 N N3    . U   C 2 40  ? -24.41100 35.38100  -1.87000  1.000 43.31754  ? 2552 U   C N3    1 
ATOM   4334 C C4    . U   C 2 40  ? -25.04100 35.60400  -0.66100  1.000 45.84804  ? 2552 U   C C4    1 
ATOM   4335 O O4    . U   C 2 40  ? -26.17200 36.08700  -0.64800  1.000 47.93395  ? 2552 U   C O4    1 
ATOM   4336 C C5    . U   C 2 40  ? -24.27700 35.23500  0.49300   1.000 47.29502  ? 2552 U   C C5    1 
ATOM   4337 C C6    . U   C 2 40  ? -23.05100 34.72100  0.33200   1.000 44.27566  ? 2552 U   C C6    1 
ATOM   4338 P P     . G   C 2 41  ? -16.63000 33.28700  -0.48500  1.000 26.44989  ? 2553 G   C P     1 
ATOM   4339 O OP1   . G   C 2 41  ? -16.17700 33.90500  0.80900   1.000 29.53764  ? 2553 G   C OP1   1 
ATOM   4340 O OP2   . G   C 2 41  ? -15.78900 33.67700  -1.66200  1.000 25.56195  ? 2553 G   C OP2   1 
ATOM   4341 O "O5'" . G   C 2 41  ? -16.51500 31.69900  -0.30300  1.000 24.90567  ? 2553 G   C "O5'" 1 
ATOM   4342 C "C5'" . G   C 2 41  ? -16.60100 30.85300  -1.47100  1.000 28.40573  ? 2553 G   C "C5'" 1 
ATOM   4343 C "C4'" . G   C 2 41  ? -15.36800 29.98700  -1.54600  1.000 26.47662  ? 2553 G   C "C4'" 1 
ATOM   4344 O "O4'" . G   C 2 41  ? -14.39500 30.61700  -2.41500  1.000 25.49336  ? 2553 G   C "O4'" 1 
ATOM   4345 C "C3'" . G   C 2 41  ? -14.63000 29.73600  -0.22200  1.000 25.86220  ? 2553 G   C "C3'" 1 
ATOM   4346 O "O3'" . G   C 2 41  ? -14.24100 28.37400  -0.13800  1.000 29.06036  ? 2553 G   C "O3'" 1 
ATOM   4347 C "C2'" . G   C 2 41  ? -13.41600 30.66600  -0.31800  1.000 26.13458  ? 2553 G   C "C2'" 1 
ATOM   4348 O "O2'" . G   C 2 41  ? -12.32900 30.23900  0.47000   1.000 29.47274  ? 2553 G   C "O2'" 1 
ATOM   4349 C "C1'" . G   C 2 41  ? -13.12900 30.55000  -1.80700  1.000 23.30200  ? 2553 G   C "C1'" 1 
ATOM   4350 N N9    . G   C 2 41  ? -12.29600 31.60200  -2.37100  1.000 27.25543  ? 2553 G   C N9    1 
ATOM   4351 C C8    . G   C 2 41  ? -12.58000 32.94200  -2.42600  1.000 25.53423  ? 2553 G   C C8    1 
ATOM   4352 N N7    . G   C 2 41  ? -11.65500 33.63900  -3.03600  1.000 25.57985  ? 2553 G   C N7    1 
ATOM   4353 C C5    . G   C 2 41  ? -10.70800 32.69800  -3.41300  1.000 26.26614  ? 2553 G   C C5    1 
ATOM   4354 C C6    . G   C 2 41  ? -9.48500  32.86100  -4.10900  1.000 30.90140  ? 2553 G   C C6    1 
ATOM   4355 O O6    . G   C 2 41  ? -8.98200  33.90800  -4.53400  1.000 28.81846  ? 2553 G   C O6    1 
ATOM   4356 N N1    . G   C 2 41  ? -8.83200  31.64300  -4.29100  1.000 27.11445  ? 2553 G   C N1    1 
ATOM   4357 C C2    . G   C 2 41  ? -9.29600  30.42700  -3.85800  1.000 31.69189  ? 2553 G   C C2    1 
ATOM   4358 N N2    . G   C 2 41  ? -8.52700  29.36400  -4.12000  1.000 26.25624  ? 2553 G   C N2    1 
ATOM   4359 N N3    . G   C 2 41  ? -10.44600 30.26700  -3.20600  1.000 25.15424  ? 2553 G   C N3    1 
ATOM   4360 C C4    . G   C 2 41  ? -11.09600 31.43900  -3.01800  1.000 26.27124  ? 2553 G   C C4    1 
ATOM   4361 P P     . U   C 2 42  ? -15.15400 27.31000  0.64100   1.000 27.92697  ? 2554 U   C P     1 
ATOM   4362 O OP1   . U   C 2 42  ? -16.59300 27.38000  0.22700   1.000 29.00101  ? 2554 U   C OP1   1 
ATOM   4363 O OP2   . U   C 2 42  ? -14.94300 27.40500  2.12000   1.000 27.61816  ? 2554 U   C OP2   1 
ATOM   4364 O "O5'" . U   C 2 42  ? -14.61500 25.87900  0.18100   1.000 28.05188  ? 2554 U   C "O5'" 1 
ATOM   4365 C "C5'" . U   C 2 42  ? -13.22300 25.56700  0.38800   1.000 28.88437  ? 2554 U   C "C5'" 1 
ATOM   4366 C "C4'" . U   C 2 42  ? -12.70700 24.71500  -0.74600  1.000 37.21015  ? 2554 U   C "C4'" 1 
ATOM   4367 O "O4'" . U   C 2 42  ? -13.60600 23.60200  -1.00500  1.000 33.17728  ? 2554 U   C "O4'" 1 
ATOM   4368 C "C3'" . U   C 2 42  ? -12.53200 25.40800  -2.10500  1.000 32.00675  ? 2554 U   C "C3'" 1 
ATOM   4369 O "O3'" . U   C 2 42  ? -11.51800 24.76900  -2.86300  1.000 34.27660  ? 2554 U   C "O3'" 1 
ATOM   4370 C "C2'" . U   C 2 42  ? -13.88100 25.11700  -2.76000  1.000 31.57429  ? 2554 U   C "C2'" 1 
ATOM   4371 O "O2'" . U   C 2 42  ? -13.86300 25.23500  -4.16400  1.000 31.49910  ? 2554 U   C "O2'" 1 
ATOM   4372 C "C1'" . U   C 2 42  ? -14.05300 23.65900  -2.34100  1.000 34.61935  ? 2554 U   C "C1'" 1 
ATOM   4373 N N1    . U   C 2 42  ? -15.45900 23.23000  -2.40500  1.000 31.81773  ? 2554 U   C N1    1 
ATOM   4374 C C2    . U   C 2 42  ? -15.86900 22.56500  -3.54500  1.000 34.73201  ? 2554 U   C C2    1 
ATOM   4375 O O2    . U   C 2 42  ? -15.11600 22.29700  -4.46800  1.000 36.33188  ? 2554 U   C O2    1 
ATOM   4376 N N3    . U   C 2 42  ? -17.19500 22.22100  -3.56200  1.000 32.13335  ? 2554 U   C N3    1 
ATOM   4377 C C4    . U   C 2 42  ? -18.13300 22.47200  -2.58200  1.000 36.50454  ? 2554 U   C C4    1 
ATOM   4378 O O4    . U   C 2 42  ? -19.29200 22.09400  -2.74300  1.000 35.00056  ? 2554 U   C O4    1 
ATOM   4379 C C5    . U   C 2 42  ? -17.63000 23.17000  -1.43600  1.000 33.25580  ? 2554 U   C C5    1 
ATOM   4380 C C6    . U   C 2 42  ? -16.33700 23.52100  -1.39100  1.000 35.64707  ? 2554 U   C C6    1 
ATOM   4381 P P     . U   C 2 43  ? -10.10000 25.45300  -3.17300  1.000 36.20891  ? 2555 U   C P     1 
ATOM   4382 O OP1   . U   C 2 43  ? -10.01600 26.88800  -2.74300  1.000 37.35871  ? 2555 U   C OP1   1 
ATOM   4383 O OP2   . U   C 2 43  ? -9.73200  25.23000  -4.61100  1.000 36.24974  ? 2555 U   C OP2   1 
ATOM   4384 O "O5'" . U   C 2 43  ? -9.03700  24.56800  -2.34000  1.000 50.91870  ? 2555 U   C "O5'" 1 
ATOM   4385 C "C5'" . U   C 2 43  ? -9.28500  24.25200  -0.95100  1.000 50.37616  ? 2555 U   C "C5'" 1 
ATOM   4386 C "C4'" . U   C 2 43  ? -9.68500  22.80200  -0.76800  1.000 53.07101  ? 2555 U   C "C4'" 1 
ATOM   4387 O "O4'" . U   C 2 43  ? -10.75000 22.41600  -1.67000  1.000 52.52704  ? 2555 U   C "O4'" 1 
ATOM   4388 C "C3'" . U   C 2 43  ? -8.61600  21.71800  -0.99500  1.000 55.77668  ? 2555 U   C "C3'" 1 
ATOM   4389 O "O3'" . U   C 2 43  ? -8.02900  21.33500  0.23900   1.000 57.45869  ? 2555 U   C "O3'" 1 
ATOM   4390 C "C2'" . U   C 2 43  ? -9.39700  20.54000  -1.60800  1.000 56.95349  ? 2555 U   C "C2'" 1 
ATOM   4391 O "O2'" . U   C 2 43  ? -9.33100  19.34200  -0.86700  1.000 58.78247  ? 2555 U   C "O2'" 1 
ATOM   4392 C "C1'" . U   C 2 43  ? -10.84400 21.02200  -1.52500  1.000 51.39786  ? 2555 U   C "C1'" 1 
ATOM   4393 N N1    . U   C 2 43  ? -11.71300 20.43600  -2.56300  1.000 48.10982  ? 2555 U   C N1    1 
ATOM   4394 C C2    . U   C 2 43  ? -12.94700 19.96100  -2.16000  1.000 50.52518  ? 2555 U   C C2    1 
ATOM   4395 O O2    . U   C 2 43  ? -13.34300 20.03600  -1.00800  1.000 49.94026  ? 2555 U   C O2    1 
ATOM   4396 N N3    . U   C 2 43  ? -13.70600 19.40400  -3.15600  1.000 52.73583  ? 2555 U   C N3    1 
ATOM   4397 C C4    . U   C 2 43  ? -13.36000 19.26900  -4.48500  1.000 47.55589  ? 2555 U   C C4    1 
ATOM   4398 O O4    . U   C 2 43  ? -14.15200 18.74900  -5.26800  1.000 53.07255  ? 2555 U   C O4    1 
ATOM   4399 C C5    . U   C 2 43  ? -12.06000 19.76700  -4.81700  1.000 50.98157  ? 2555 U   C C5    1 
ATOM   4400 C C6    . U   C 2 43  ? -11.29600 20.31800  -3.86300  1.000 50.31043  ? 2555 U   C C6    1 
ATOM   4401 P P     . C   C 2 44  ? -6.43800  21.18500  0.38800   1.000 63.10157  ? 2556 C   C P     1 
ATOM   4402 O OP1   . C   C 2 44  ? -5.89700  21.97100  1.55500   1.000 61.99095  ? 2556 C   C OP1   1 
ATOM   4403 O OP2   . C   C 2 44  ? -5.71600  21.42700  -0.91600  1.000 61.30196  ? 2556 C   C OP2   1 
ATOM   4404 O "O5'" . C   C 2 44  ? -6.25200  19.63900  0.76200   1.000 64.49770  ? 2556 C   C "O5'" 1 
ATOM   4405 C "C5'" . C   C 2 44  ? -6.20200  18.66000  -0.29800  1.000 65.79400  ? 2556 C   C "C5'" 1 
ATOM   4406 C "C4'" . C   C 2 44  ? -6.03300  17.29600  0.32000   1.000 67.75033  ? 2556 C   C "C4'" 1 
ATOM   4407 O "O4'" . C   C 2 44  ? -4.66700  17.14800  0.77300   1.000 69.55660  ? 2556 C   C "O4'" 1 
ATOM   4408 C "C3'" . C   C 2 44  ? -6.86600  17.02700  1.57700   1.000 66.78976  ? 2556 C   C "C3'" 1 
ATOM   4409 O "O3'" . C   C 2 44  ? -8.18000  16.61300  1.22800   1.000 65.08784  ? 2556 C   C "O3'" 1 
ATOM   4410 C "C2'" . C   C 2 44  ? -6.05800  15.92100  2.26800   1.000 70.52614  ? 2556 C   C "C2'" 1 
ATOM   4411 O "O2'" . C   C 2 44  ? -6.39600  14.63200  1.80300   1.000 69.17487  ? 2556 C   C "O2'" 1 
ATOM   4412 C "C1'" . C   C 2 44  ? -4.61800  16.22500  1.83700   1.000 70.32596  ? 2556 C   C "C1'" 1 
ATOM   4413 N N1    . C   C 2 44  ? -3.78800  16.80600  2.92500   1.000 70.63575  ? 2556 C   C N1    1 
ATOM   4414 C C2    . C   C 2 44  ? -2.92400  15.95500  3.61800   1.000 70.58173  ? 2556 C   C C2    1 
ATOM   4415 O O2    . C   C 2 44  ? -2.89200  14.75500  3.30900   1.000 70.25535  ? 2556 C   C O2    1 
ATOM   4416 N N3    . C   C 2 44  ? -2.15200  16.46800  4.60400   1.000 69.38449  ? 2556 C   C N3    1 
ATOM   4417 C C4    . C   C 2 44  ? -2.21600  17.76900  4.90600   1.000 64.72785  ? 2556 C   C C4    1 
ATOM   4418 N N4    . C   C 2 44  ? -1.43700  18.21000  5.88000   1.000 62.55198  ? 2556 C   C N4    1 
ATOM   4419 C C5    . C   C 2 44  ? -3.08600  18.65000  4.21000   1.000 64.87694  ? 2556 C   C C5    1 
ATOM   4420 C C6    . C   C 2 44  ? -3.84300  18.13300  3.23100   1.000 68.34948  ? 2556 C   C C6    1 
ATOM   4421 P P     . G   C 2 45  ? -9.41300  16.85200  2.22400   1.000 65.79229  ? 2557 G   C P     1 
ATOM   4422 O OP1   . G   C 2 45  ? -9.00400  16.78200  3.67300   1.000 63.57317  ? 2557 G   C OP1   1 
ATOM   4423 O OP2   . G   C 2 45  ? -10.62900 16.02800  1.90000   1.000 62.91190  ? 2557 G   C OP2   1 
ATOM   4424 O "O5'" . G   C 2 45  ? -9.81800  18.37500  1.93600   1.000 61.39849  ? 2557 G   C "O5'" 1 
ATOM   4425 C "C5'" . G   C 2 45  ? -10.57900 19.07400  2.93900   1.000 50.96548  ? 2557 G   C "C5'" 1 
ATOM   4426 C "C4'" . G   C 2 45  ? -10.77200 20.50300  2.50400   1.000 46.52241  ? 2557 G   C "C4'" 1 
ATOM   4427 O "O4'" . G   C 2 45  ? -11.84600 20.57000  1.53600   1.000 42.00016  ? 2557 G   C "O4'" 1 
ATOM   4428 C "C3'" . G   C 2 45  ? -11.18400 21.47400  3.60900   1.000 43.87838  ? 2557 G   C "C3'" 1 
ATOM   4429 O "O3'" . G   C 2 45  ? -10.03000 21.96300  4.27700   1.000 43.78301  ? 2557 G   C "O3'" 1 
ATOM   4430 C "C2'" . G   C 2 45  ? -11.92300 22.55000  2.81600   1.000 41.25390  ? 2557 G   C "C2'" 1 
ATOM   4431 O "O2'" . G   C 2 45  ? -11.04600 23.47800  2.22100   1.000 38.46395  ? 2557 G   C "O2'" 1 
ATOM   4432 C "C1'" . G   C 2 45  ? -12.64400 21.70900  1.76900   1.000 40.69066  ? 2557 G   C "C1'" 1 
ATOM   4433 N N9    . G   C 2 45  ? -13.97300 21.26500  2.16900   1.000 38.94851  ? 2557 G   C N9    1 
ATOM   4434 C C8    . G   C 2 45  ? -14.40900 19.96800  2.25300   1.000 38.60238  ? 2557 G   C C8    1 
ATOM   4435 N N7    . G   C 2 45  ? -15.65800 19.86500  2.62800   1.000 36.26980  ? 2557 G   C N7    1 
ATOM   4436 C C5    . G   C 2 45  ? -16.07500 21.17600  2.79600   1.000 36.22692  ? 2557 G   C C5    1 
ATOM   4437 C C6    . G   C 2 45  ? -17.33500 21.68400  3.19100   1.000 37.52117  ? 2557 G   C C6    1 
ATOM   4438 O O6    . G   C 2 45  ? -18.35700 21.05100  3.48200   1.000 37.56182  ? 2557 G   C O6    1 
ATOM   4439 N N1    . G   C 2 45  ? -17.33000 23.07800  3.23400   1.000 33.94010  ? 2557 G   C N1    1 
ATOM   4440 C C2    . G   C 2 45  ? -16.25500 23.87600  2.92900   1.000 34.62029  ? 2557 G   C C2    1 
ATOM   4441 N N2    . G   C 2 45  ? -16.43800 25.19700  3.02600   1.000 32.59862  ? 2557 G   C N2    1 
ATOM   4442 N N3    . G   C 2 45  ? -15.07000 23.40200  2.55600   1.000 35.61773  ? 2557 G   C N3    1 
ATOM   4443 C C4    . G   C 2 45  ? -15.05000 22.05000  2.50900   1.000 35.46000  ? 2557 G   C C4    1 
ATOM   4444 P P     . C   C 2 46  ? -9.99400  22.15700  5.87100   1.000 40.38101  ? 2558 C   C P     1 
ATOM   4445 O OP1   . C   C 2 46  ? -8.59500  22.41100  6.35600   1.000 44.10130  ? 2558 C   C OP1   1 
ATOM   4446 O OP2   . C   C 2 46  ? -10.70000 21.03300  6.57400   1.000 44.28074  ? 2558 C   C OP2   1 
ATOM   4447 O "O5'" . C   C 2 46  ? -10.84200 23.48600  6.15300   1.000 39.84669  ? 2558 C   C "O5'" 1 
ATOM   4448 C "C5'" . C   C 2 46  ? -10.41900 24.73200  5.55200   1.000 37.33316  ? 2558 C   C "C5'" 1 
ATOM   4449 C "C4'" . C   C 2 46  ? -11.52100 25.74200  5.72700   1.000 33.71306  ? 2558 C   C "C4'" 1 
ATOM   4450 O "O4'" . C   C 2 46  ? -12.67100 25.34600  4.94000   1.000 32.99860  ? 2558 C   C "O4'" 1 
ATOM   4451 C "C3'" . C   C 2 46  ? -12.08400 25.85600  7.14600   1.000 35.14725  ? 2558 C   C "C3'" 1 
ATOM   4452 O "O3'" . C   C 2 46  ? -11.27600 26.64600  8.01100   1.000 36.14944  ? 2558 C   C "O3'" 1 
ATOM   4453 C "C2'" . C   C 2 46  ? -13.45600 26.47600  6.87400   1.000 36.39019  ? 2558 C   C "C2'" 1 
ATOM   4454 O "O2'" . C   C 2 46  ? -13.39400 27.85900  6.61000   1.000 33.29959  ? 2558 C   C "O2'" 1 
ATOM   4455 C "C1'" . C   C 2 46  ? -13.86100 25.72000  5.60300   1.000 34.48021  ? 2558 C   C "C1'" 1 
ATOM   4456 N N1    . C   C 2 46  ? -14.66800 24.50200  5.88400   1.000 33.10450  ? 2558 C   C N1    1 
ATOM   4457 C C2    . C   C 2 46  ? -16.00500 24.67100  6.24900   1.000 35.55024  ? 2558 C   C C2    1 
ATOM   4458 O O2    . C   C 2 46  ? -16.46800 25.81700  6.32300   1.000 34.74566  ? 2558 C   C O2    1 
ATOM   4459 N N3    . C   C 2 46  ? -16.76000 23.57600  6.49500   1.000 38.53833  ? 2558 C   C N3    1 
ATOM   4460 C C4    . C   C 2 46  ? -16.23400 22.35200  6.39600   1.000 38.13418  ? 2558 C   C C4    1 
ATOM   4461 N N4    . C   C 2 46  ? -17.02400 21.32200  6.65300   1.000 38.62416  ? 2558 C   C N4    1 
ATOM   4462 C C5    . C   C 2 46  ? -14.87500 22.15900  6.03000   1.000 37.15410  ? 2558 C   C C5    1 
ATOM   4463 C C6    . C   C 2 46  ? -14.13600 23.25100  5.78400   1.000 37.50231  ? 2558 C   C C6    1 
ATOM   4464 P P     . C   C 2 47  ? -11.21000 26.33700  9.58800   1.000 37.13538  ? 2559 C   C P     1 
ATOM   4465 O OP1   . C   C 2 47  ? -10.09900 27.06100  10.28100  1.000 38.44115  ? 2559 C   C OP1   1 
ATOM   4466 O OP2   . C   C 2 47  ? -11.21500 24.85500  9.80900   1.000 35.15180  ? 2559 C   C OP2   1 
ATOM   4467 O "O5'" . C   C 2 47  ? -12.57300 26.89300  10.20000  1.000 34.04408  ? 2559 C   C "O5'" 1 
ATOM   4468 C "C5'" . C   C 2 47  ? -12.89900 28.27900  10.00500  1.000 34.58618  ? 2559 C   C "C5'" 1 
ATOM   4469 C "C4'" . C   C 2 47  ? -14.28900 28.52000  10.52800  1.000 38.08459  ? 2559 C   C "C4'" 1 
ATOM   4470 O "O4'" . C   C 2 47  ? -15.25700 27.86100  9.67500   1.000 37.65121  ? 2559 C   C "O4'" 1 
ATOM   4471 C "C3'" . C   C 2 47  ? -14.58300 27.94100  11.91300  1.000 35.19988  ? 2559 C   C "C3'" 1 
ATOM   4472 O "O3'" . C   C 2 47  ? -14.05000 28.76800  12.94000  1.000 40.79714  ? 2559 C   C "O3'" 1 
ATOM   4473 C "C2'" . C   C 2 47  ? -16.11000 27.93500  11.88200  1.000 37.70374  ? 2559 C   C "C2'" 1 
ATOM   4474 O "O2'" . C   C 2 47  ? -16.63900 29.22900  12.06000  1.000 40.16490  ? 2559 C   C "O2'" 1 
ATOM   4475 C "C1'" . C   C 2 47  ? -16.37300 27.47000  10.44700  1.000 38.95356  ? 2559 C   C "C1'" 1 
ATOM   4476 N N1    . C   C 2 47  ? -16.53800 25.99600  10.33700  1.000 36.56106  ? 2559 C   C N1    1 
ATOM   4477 C C2    . C   C 2 47  ? -17.74800 25.42400  10.73700  1.000 39.96491  ? 2559 C   C C2    1 
ATOM   4478 O O2    . C   C 2 47  ? -18.64700 26.15700  11.17100  1.000 38.59819  ? 2559 C   C O2    1 
ATOM   4479 N N3    . C   C 2 47  ? -17.90700 24.08700  10.63000  1.000 39.43541  ? 2559 C   C N3    1 
ATOM   4480 C C4    . C   C 2 47  ? -16.91600 23.32300  10.16100  1.000 39.30307  ? 2559 C   C C4    1 
ATOM   4481 N N4    . C   C 2 47  ? -17.12700 22.02100  10.08200  1.000 40.32858  ? 2559 C   C N4    1 
ATOM   4482 C C5    . C   C 2 47  ? -15.67700 23.88600  9.75400   1.000 37.75530  ? 2559 C   C C5    1 
ATOM   4483 C C6    . C   C 2 47  ? -15.53400 25.21300  9.85300   1.000 33.97031  ? 2559 C   C C6    1 
ATOM   4484 P P     . C   C 2 48  ? -13.68300 28.19300  14.39700  1.000 41.49126  ? 2560 C   C P     1 
ATOM   4485 O OP1   . C   C 2 48  ? -13.05900 29.26400  15.24900  1.000 43.60936  ? 2560 C   C OP1   1 
ATOM   4486 O OP2   . C   C 2 48  ? -12.88700 26.91600  14.34000  1.000 37.06681  ? 2560 C   C OP2   1 
ATOM   4487 O "O5'" . C   C 2 48  ? -15.08700 27.82900  15.08000  1.000 44.70454  ? 2560 C   C "O5'" 1 
ATOM   4488 C "C5'" . C   C 2 48  ? -16.05300 28.88400  15.26500  1.000 44.38982  ? 2560 C   C "C5'" 1 
ATOM   4489 C "C4'" . C   C 2 48  ? -17.36100 28.28100  15.70600  1.000 50.63154  ? 2560 C   C "C4'" 1 
ATOM   4490 O "O4'" . C   C 2 48  ? -17.90400 27.42300  14.67500  1.000 45.98886  ? 2560 C   C "O4'" 1 
ATOM   4491 C "C3'" . C   C 2 48  ? -17.27800 27.34800  16.91300  1.000 53.19335  ? 2560 C   C "C3'" 1 
ATOM   4492 O "O3'" . C   C 2 48  ? -17.16400 28.11200  18.10100  1.000 57.80625  ? 2560 C   C "O3'" 1 
ATOM   4493 C "C2'" . C   C 2 48  ? -18.61100 26.61000  16.79600  1.000 51.84335  ? 2560 C   C "C2'" 1 
ATOM   4494 O "O2'" . C   C 2 48  ? -19.69200 27.37900  17.27400  1.000 51.31335  ? 2560 C   C "O2'" 1 
ATOM   4495 C "C1'" . C   C 2 48  ? -18.73900 26.45500  15.27600  1.000 49.16955  ? 2560 C   C "C1'" 1 
ATOM   4496 N N1    . C   C 2 48  ? -18.33100 25.10800  14.80000  1.000 47.26617  ? 2560 C   C N1    1 
ATOM   4497 C C2    . C   C 2 48  ? -19.24200 24.06000  14.93900  1.000 52.78881  ? 2560 C   C C2    1 
ATOM   4498 O O2    . C   C 2 48  ? -20.34600 24.29300  15.45000  1.000 54.64663  ? 2560 C   C O2    1 
ATOM   4499 N N3    . C   C 2 48  ? -18.89800 22.83000  14.49500  1.000 46.88924  ? 2560 C   C N3    1 
ATOM   4500 C C4    . C   C 2 48  ? -17.69700 22.62300  13.94500  1.000 48.54189  ? 2560 C   C C4    1 
ATOM   4501 N N4    . C   C 2 48  ? -17.40700 21.39900  13.53700  1.000 48.50614  ? 2560 C   C N4    1 
ATOM   4502 C C5    . C   C 2 48  ? -16.75500 23.67700  13.80400  1.000 44.55276  ? 2560 C   C C5    1 
ATOM   4503 C C6    . C   C 2 48  ? -17.11000 24.89400  14.23700  1.000 42.27078  ? 2560 C   C C6    1 
ATOM   4504 P P     . A   C 2 49  ? -16.53500 27.45800  19.41900  1.000 62.91336  ? 2561 A   C P     1 
ATOM   4505 O OP1   . A   C 2 49  ? -15.78500 28.43900  20.28800  1.000 69.42335  ? 2561 A   C OP1   1 
ATOM   4506 O OP2   . A   C 2 49  ? -15.79300 26.17500  19.13300  1.000 54.12710  ? 2561 A   C OP2   1 
ATOM   4507 O "O5'" . A   C 2 49  ? -17.87200 27.06700  20.19400  1.000 63.16335  ? 2561 A   C "O5'" 1 
ATOM   4508 C "C5'" . A   C 2 49  ? -18.06900 25.68300  20.51300  1.000 68.58335  ? 2561 A   C "C5'" 1 
ATOM   4509 C "C4'" . A   C 2 49  ? -19.52800 25.43100  20.77900  1.000 73.29335  ? 2561 A   C "C4'" 1 
ATOM   4510 O "O4'" . A   C 2 49  ? -20.19600 25.15000  19.52400  1.000 68.75335  ? 2561 A   C "O4'" 1 
ATOM   4511 C "C3'" . A   C 2 49  ? -19.80500 24.23000  21.69000  1.000 81.70335  ? 2561 A   C "C3'" 1 
ATOM   4512 O "O3'" . A   C 2 49  ? -20.12100 24.67200  23.00400  1.000 88.79335  ? 2561 A   C "O3'" 1 
ATOM   4513 C "C2'" . A   C 2 49  ? -20.97900 23.51900  21.01300  1.000 77.44335  ? 2561 A   C "C2'" 1 
ATOM   4514 O "O2'" . A   C 2 49  ? -22.21700 24.00100  21.48300  1.000 77.86335  ? 2561 A   C "O2'" 1 
ATOM   4515 C "C1'" . A   C 2 49  ? -20.74000 23.85200  19.54400  1.000 72.21335  ? 2561 A   C "C1'" 1 
ATOM   4516 N N9    . A   C 2 49  ? -19.82000 22.95300  18.85700  1.000 66.00335  ? 2561 A   C N9    1 
ATOM   4517 C C8    . A   C 2 49  ? -18.58700 23.27200  18.34900  1.000 63.00335  ? 2561 A   C C8    1 
ATOM   4518 N N7    . A   C 2 49  ? -17.98300 22.26800  17.76900  1.000 62.75335  ? 2561 A   C N7    1 
ATOM   4519 C C5    . A   C 2 49  ? -18.88300 21.22200  17.88300  1.000 65.43335  ? 2561 A   C C5    1 
ATOM   4520 C C6    . A   C 2 49  ? -18.82600 19.88500  17.45800  1.000 68.45909  ? 2561 A   C C6    1 
ATOM   4521 N N6    . A   C 2 49  ? -17.79200 19.36400  16.80800  1.000 67.54692  ? 2561 A   C N6    1 
ATOM   4522 N N1    . A   C 2 49  ? -19.88800 19.09800  17.73500  1.000 70.17551  ? 2561 A   C N1    1 
ATOM   4523 C C2    . A   C 2 49  ? -20.92200 19.63000  18.39400  1.000 72.34335  ? 2561 A   C C2    1 
ATOM   4524 N N3    . A   C 2 49  ? -21.08800 20.87200  18.83700  1.000 71.00335  ? 2561 A   C N3    1 
ATOM   4525 C C4    . A   C 2 49  ? -20.01900 21.63000  18.55100  1.000 67.94335  ? 2561 A   C C4    1 
ATOM   4526 P P     . U   C 2 50  ? -19.00100 24.71600  24.15400  1.000 93.05335  ? 2562 U   C P     1 
ATOM   4527 O OP1   . U   C 2 50  ? -19.39500 25.64400  25.27700  1.000 93.90335  ? 2562 U   C OP1   1 
ATOM   4528 O OP2   . U   C 2 50  ? -17.60100 24.94100  23.63900  1.000 83.87335  ? 2562 U   C OP2   1 
ATOM   4529 O "O5'" . U   C 2 50  ? -19.02000 23.22700  24.75600  1.000 94.77335  ? 2562 U   C "O5'" 1 
ATOM   4530 C "C5'" . U   C 2 50  ? -18.31900 22.18200  24.04300  1.000 94.78335  ? 2562 U   C "C5'" 1 
ATOM   4531 C "C4'" . U   C 2 50  ? -19.33900 21.22800  23.47600  1.000 95.43335  ? 2562 U   C "C4'" 1 
ATOM   4532 O "O4'" . U   C 2 50  ? -19.01800 20.92600  22.10000  1.000 89.16335  ? 2562 U   C "O4'" 1 
ATOM   4533 C "C3'" . U   C 2 50  ? -19.41600 19.86200  24.16000  1.000 101.82335 ? 2562 U   C "C3'" 1 
ATOM   4534 O "O3'" . U   C 2 50  ? -20.33000 19.93200  25.24300  1.000 107.72335 ? 2562 U   C "O3'" 1 
ATOM   4535 C "C2'" . U   C 2 50  ? -19.94500 18.94700  23.05200  1.000 100.32335 ? 2562 U   C "C2'" 1 
ATOM   4536 O "O2'" . U   C 2 50  ? -21.34900 18.80500  23.09800  1.000 103.66335 ? 2562 U   C "O2'" 1 
ATOM   4537 C "C1'" . U   C 2 50  ? -19.54500 19.66300  21.75700  1.000 90.91335  ? 2562 U   C "C1'" 1 
ATOM   4538 N N1    . U   C 2 50  ? -18.51600 18.95900  20.96700  1.000 86.96335  ? 2562 U   C N1    1 
ATOM   4539 C C2    . U   C 2 50  ? -18.77200 17.66100  20.56000  1.000 89.75335  ? 2562 U   C C2    1 
ATOM   4540 O O2    . U   C 2 50  ? -19.80400 17.05800  20.81700  1.000 93.77335  ? 2562 U   C O2    1 
ATOM   4541 N N3    . U   C 2 50  ? -17.77500 17.08900  19.81500  1.000 89.05335  ? 2562 U   C N3    1 
ATOM   4542 C C4    . U   C 2 50  ? -16.57700 17.66300  19.44300  1.000 87.49335  ? 2562 U   C C4    1 
ATOM   4543 O O4    . U   C 2 50  ? -15.77900 17.00700  18.77800  1.000 90.03335  ? 2562 U   C O4    1 
ATOM   4544 C C5    . U   C 2 50  ? -16.38900 19.00800  19.89700  1.000 84.81335  ? 2562 U   C C5    1 
ATOM   4545 C C6    . U   C 2 50  ? -17.34900 19.59600  20.62500  1.000 84.95335  ? 2562 U   C C6    1 
ATOM   4546 P P     . U   C 2 51  ? -19.96000 19.30300  26.67000  1.000 114.80335 ? 2563 U   C P     1 
ATOM   4547 O OP1   . U   C 2 51  ? -20.75500 19.92000  27.80400  1.000 106.04335 ? 2563 U   C OP1   1 
ATOM   4548 O OP2   . U   C 2 51  ? -18.46300 19.27700  26.90500  1.000 108.15335 ? 2563 U   C OP2   1 
ATOM   4549 O "O5'" . U   C 2 51  ? -20.45000 17.77500  26.49100  1.000 112.11335 ? 2563 U   C "O5'" 1 
ATOM   4550 C "C5'" . U   C 2 51  ? -19.44800 16.73000  26.42200  1.000 110.00335 ? 2563 U   C "C5'" 1 
ATOM   4551 C "C4'" . U   C 2 51  ? -19.90700 15.64800  25.47500  1.000 109.33335 ? 2563 U   C "C4'" 1 
ATOM   4552 O "O4'" . U   C 2 51  ? -19.43600 15.94200  24.13600  1.000 106.67335 ? 2563 U   C "O4'" 1 
ATOM   4553 C "C3'" . U   C 2 51  ? -19.38700 14.23600  25.77400  1.000 111.08335 ? 2563 U   C "C3'" 1 
ATOM   4554 O "O3'" . U   C 2 51  ? -20.30800 13.23900  25.35100  1.000 112.33335 ? 2563 U   C "O3'" 1 
ATOM   4555 C "C2'" . U   C 2 51  ? -18.07400 14.19300  24.98400  1.000 111.16335 ? 2563 U   C "C2'" 1 
ATOM   4556 O "O2'" . U   C 2 51  ? -17.74800 12.90100  24.51800  1.000 113.26335 ? 2563 U   C "O2'" 1 
ATOM   4557 C "C1'" . U   C 2 51  ? -18.39400 15.06400  23.77000  1.000 105.99335 ? 2563 U   C "C1'" 1 
ATOM   4558 N N1    . U   C 2 51  ? -17.23300 15.86400  23.33900  1.000 102.81335 ? 2563 U   C N1    1 
ATOM   4559 C C2    . U   C 2 51  ? -16.34100 15.27100  22.46600  1.000 103.09016 ? 2563 U   C C2    1 
ATOM   4560 O O2    . U   C 2 51  ? -16.48600 14.13500  22.03500  1.000 103.34179 ? 2563 U   C O2    1 
ATOM   4561 N N3    . U   C 2 51  ? -15.27400 16.05800  22.11100  1.000 101.80667 ? 2563 U   C N3    1 
ATOM   4562 C C4    . U   C 2 51  ? -15.01300 17.34600  22.53100  1.000 99.11311  ? 2563 U   C C4    1 
ATOM   4563 O O4    . U   C 2 51  ? -14.01200 17.92700  22.11400  1.000 96.82089  ? 2563 U   C O4    1 
ATOM   4564 C C5    . U   C 2 51  ? -15.98300 17.88900  23.43400  1.000 100.44335 ? 2563 U   C C5    1 
ATOM   4565 C C6    . U   C 2 51  ? -17.03300 17.14200  23.80200  1.000 102.70335 ? 2563 U   C C6    1 
ATOM   4566 P P     . G   C 2 55  ? -13.17300 9.99000   14.65200  1.000 128.00273 ? 2567 G   C P     1 
ATOM   4567 O OP1   . G   C 2 55  ? -12.50600 10.17000  13.30300  1.000 122.52539 ? 2567 G   C OP1   1 
ATOM   4568 O OP2   . G   C 2 55  ? -12.19500 10.01500  15.80800  1.000 121.65258 ? 2567 G   C OP2   1 
ATOM   4569 O "O5'" . G   C 2 55  ? -13.81900 8.51200   14.64500  1.000 122.51135 ? 2567 G   C "O5'" 1 
ATOM   4570 C "C5'" . G   C 2 55  ? -13.56900 7.64400   13.51300  1.000 121.80931 ? 2567 G   C "C5'" 1 
ATOM   4571 C "C4'" . G   C 2 55  ? -12.90800 6.37900   13.99900  1.000 122.31868 ? 2567 G   C "C4'" 1 
ATOM   4572 O "O4'" . G   C 2 55  ? -13.67700 5.81300   15.08900  1.000 122.94432 ? 2567 G   C "O4'" 1 
ATOM   4573 C "C3'" . G   C 2 55  ? -12.82900 5.22700   12.99700  1.000 123.51584 ? 2567 G   C "C3'" 1 
ATOM   4574 O "O3'" . G   C 2 55  ? -11.76300 5.38000   12.07400  1.000 124.20408 ? 2567 G   C "O3'" 1 
ATOM   4575 C "C2'" . G   C 2 55  ? -12.58900 4.05100   13.94100  1.000 122.75195 ? 2567 G   C "C2'" 1 
ATOM   4576 O "O2'" . G   C 2 55  ? -11.24700 3.93600   14.35800  1.000 122.10238 ? 2567 G   C "O2'" 1 
ATOM   4577 C "C1'" . G   C 2 55  ? -13.50700 4.41000   15.10700  1.000 122.94489 ? 2567 G   C "C1'" 1 
ATOM   4578 N N9    . G   C 2 55  ? -14.81400 3.76500   15.03400  1.000 119.44332 ? 2567 G   C N9    1 
ATOM   4579 C C8    . G   C 2 55  ? -16.04400 4.35500   15.16800  1.000 116.81049 ? 2567 G   C C8    1 
ATOM   4580 N N7    . G   C 2 55  ? -17.03800 3.50600   15.06500  1.000 116.53569 ? 2567 G   C N7    1 
ATOM   4581 C C5    . G   C 2 55  ? -16.42100 2.28000   14.85100  1.000 116.54539 ? 2567 G   C C5    1 
ATOM   4582 C C6    . G   C 2 55  ? -16.98400 0.99400   14.66400  1.000 112.42851 ? 2567 G   C C6    1 
ATOM   4583 O O6    . G   C 2 55  ? -18.17900 0.67500   14.65000  1.000 111.96526 ? 2567 G   C O6    1 
ATOM   4584 N N1    . G   C 2 55  ? -15.99700 0.02700   14.47800  1.000 112.21804 ? 2567 G   C N1    1 
ATOM   4585 C C2    . G   C 2 55  ? -14.64600 0.26600   14.47300  1.000 113.68437 ? 2567 G   C C2    1 
ATOM   4586 N N2    . G   C 2 55  ? -13.84200 -0.78600  14.27700  1.000 112.40718 ? 2567 G   C N2    1 
ATOM   4587 N N3    . G   C 2 55  ? -14.11300 1.46900   14.65300  1.000 115.69531 ? 2567 G   C N3    1 
ATOM   4588 C C4    . G   C 2 55  ? -15.05300 2.42600   14.83200  1.000 117.47599 ? 2567 G   C C4    1 
ATOM   4589 P P     . C   C 2 56  ? -12.07200 5.50400   10.50500  1.000 126.93790 ? 2568 C   C P     1 
ATOM   4590 O OP1   . C   C 2 56  ? -11.41700 6.72600   9.90400   1.000 125.45335 ? 2568 C   C OP1   1 
ATOM   4591 O OP2   . C   C 2 56  ? -13.55500 5.38900   10.21200  1.000 125.20756 ? 2568 C   C OP2   1 
ATOM   4592 O "O5'" . C   C 2 56  ? -11.37500 4.20200   9.86400   1.000 127.12324 ? 2568 C   C "O5'" 1 
ATOM   4593 C "C5'" . C   C 2 56  ? -10.54500 3.37200   10.71100  1.000 125.40662 ? 2568 C   C "C5'" 1 
ATOM   4594 C "C4'" . C   C 2 56  ? -10.91300 1.92400   10.51300  1.000 122.61546 ? 2568 C   C "C4'" 1 
ATOM   4595 O "O4'" . C   C 2 56  ? -11.82800 1.49800   11.55400  1.000 124.44459 ? 2568 C   C "O4'" 1 
ATOM   4596 C "C3'" . C   C 2 56  ? -11.68900 1.58300   9.23900   1.000 122.00269 ? 2568 C   C "C3'" 1 
ATOM   4597 O "O3'" . C   C 2 56  ? -10.88800 1.54200   8.06800   1.000 123.85197 ? 2568 C   C "O3'" 1 
ATOM   4598 C "C2'" . C   C 2 56  ? -12.20300 0.19400   9.61500   1.000 120.31253 ? 2568 C   C "C2'" 1 
ATOM   4599 O "O2'" . C   C 2 56  ? -11.18900 -0.78600  9.57000   1.000 120.13871 ? 2568 C   C "O2'" 1 
ATOM   4600 C "C1'" . C   C 2 56  ? -12.63100 0.44400   11.06400  1.000 120.17164 ? 2568 C   C "C1'" 1 
ATOM   4601 N N1    . C   C 2 56  ? -14.06500 0.82500   11.16900  1.000 117.30190 ? 2568 C   C N1    1 
ATOM   4602 C C2    . C   C 2 56  ? -15.01300 -0.19700  11.12100  1.000 112.25553 ? 2568 C   C C2    1 
ATOM   4603 O O2    . C   C 2 56  ? -14.62800 -1.36900  11.00500  1.000 110.48452 ? 2568 C   C O2    1 
ATOM   4604 N N3    . C   C 2 56  ? -16.32200 0.12100   11.22100  1.000 110.13978 ? 2568 C   C N3    1 
ATOM   4605 C C4    . C   C 2 56  ? -16.70300 1.39400   11.35400  1.000 112.84949 ? 2568 C   C C4    1 
ATOM   4606 N N4    . C   C 2 56  ? -18.00100 1.64000   11.43900  1.000 111.61200 ? 2568 C   C N4    1 
ATOM   4607 C C5    . C   C 2 56  ? -15.75200 2.45000   11.40100  1.000 116.58034 ? 2568 C   C C5    1 
ATOM   4608 C C6    . C   C 2 56  ? -14.45600 2.12400   11.30300  1.000 117.93578 ? 2568 C   C C6    1 
ATOM   4609 P P     . G   C 2 57  ? -11.53900 1.90400   6.64700   1.000 128.07864 ? 2569 G   C P     1 
ATOM   4610 O OP1   . G   C 2 57  ? -10.68200 1.44700   5.48200   1.000 125.48335 ? 2569 G   C OP1   1 
ATOM   4611 O OP2   . G   C 2 57  ? -11.96800 3.35200   6.56900   1.000 126.11335 ? 2569 G   C OP2   1 
ATOM   4612 O "O5'" . G   C 2 57  ? -12.89400 1.03800   6.61700   1.000 121.29292 ? 2569 G   C "O5'" 1 
ATOM   4613 C "C5'" . G   C 2 57  ? -13.22500 0.31100   5.41200   1.000 117.78335 ? 2569 G   C "C5'" 1 
ATOM   4614 C "C4'" . G   C 2 57  ? -13.18500 -1.16800  5.70000   1.000 115.24335 ? 2569 G   C "C4'" 1 
ATOM   4615 O "O4'" . G   C 2 57  ? -13.37600 -1.38700  7.12100   1.000 114.68937 ? 2569 G   C "O4'" 1 
ATOM   4616 C "C3'" . G   C 2 57  ? -14.27800 -2.00300  5.02500   1.000 112.44335 ? 2569 G   C "C3'" 1 
ATOM   4617 O "O3'" . G   C 2 57  ? -13.86100 -2.42800  3.73300   1.000 115.06335 ? 2569 G   C "O3'" 1 
ATOM   4618 C "C2'" . G   C 2 57  ? -14.45100 -3.13800  6.03200   1.000 109.95226 ? 2569 G   C "C2'" 1 
ATOM   4619 O "O2'" . G   C 2 57  ? -13.40700 -4.08000  5.94600   1.000 108.44335 ? 2569 G   C "O2'" 1 
ATOM   4620 C "C1'" . G   C 2 57  ? -14.39500 -2.33800  7.32600   1.000 110.22094 ? 2569 G   C "C1'" 1 
ATOM   4621 N N9    . G   C 2 57  ? -15.62800 -1.62400  7.63200   1.000 105.46643 ? 2569 G   C N9    1 
ATOM   4622 C C8    . G   C 2 57  ? -15.77200 -0.26900  7.79000   1.000 107.52633 ? 2569 G   C C8    1 
ATOM   4623 N N7    . G   C 2 57  ? -17.00200 0.09700   8.04700   1.000 104.35335 ? 2569 G   C N7    1 
ATOM   4624 C C5    . G   C 2 57  ? -17.71300 -1.09500  8.06500   1.000 102.78351 ? 2569 G   C C5    1 
ATOM   4625 C C6    . G   C 2 57  ? -19.09100 -1.32400  8.29500   1.000 97.65612  ? 2569 G   C C6    1 
ATOM   4626 O O6    . G   C 2 57  ? -19.96900 -0.48900  8.54300   1.000 93.25386  ? 2569 G   C O6    1 
ATOM   4627 N N1    . G   C 2 57  ? -19.40100 -2.68400  8.22300   1.000 97.37504  ? 2569 G   C N1    1 
ATOM   4628 C C2    . G   C 2 57  ? -18.49900 -3.68500  7.96100   1.000 99.90591  ? 2569 G   C C2    1 
ATOM   4629 N N2    . G   C 2 57  ? -18.97500 -4.93600  7.93100   1.000 97.30909  ? 2569 G   C N2    1 
ATOM   4630 N N3    . G   C 2 57  ? -17.20300 -3.47400  7.74400   1.000 102.64807 ? 2569 G   C N3    1 
ATOM   4631 C C4    . G   C 2 57  ? -16.88100 -2.16100  7.80900   1.000 103.69034 ? 2569 G   C C4    1 
ATOM   4632 P P     . G   C 2 58  ? -14.65900 -1.99800  2.40600   1.000 119.23335 ? 2570 G   C P     1 
ATOM   4633 O OP1   . G   C 2 58  ? -13.75200 -2.03200  1.19600   1.000 117.85335 ? 2570 G   C OP1   1 
ATOM   4634 O OP2   . G   C 2 58  ? -15.47100 -0.72100  2.51000   1.000 121.45335 ? 2570 G   C OP2   1 
ATOM   4635 O "O5'" . G   C 2 58  ? -15.72400 -3.18800  2.22000   1.000 109.26335 ? 2570 G   C "O5'" 1 
ATOM   4636 C "C5'" . G   C 2 58  ? -15.29600 -4.54600  2.45700   1.000 107.54335 ? 2570 G   C "C5'" 1 
ATOM   4637 C "C4'" . G   C 2 58  ? -16.47700 -5.36000  2.92000   1.000 105.63335 ? 2570 G   C "C4'" 1 
ATOM   4638 O "O4'" . G   C 2 58  ? -16.86400 -4.94200  4.25300   1.000 102.68070 ? 2570 G   C "O4'" 1 
ATOM   4639 C "C3'" . G   C 2 58  ? -17.77000 -5.20400  2.11600   1.000 102.25137 ? 2570 G   C "C3'" 1 
ATOM   4640 O "O3'" . G   C 2 58  ? -17.78300 -5.96300  0.91700   1.000 103.14885 ? 2570 G   C "O3'" 1 
ATOM   4641 C "C2'" . G   C 2 58  ? -18.77600 -5.74300  3.13000   1.000 100.37311 ? 2570 G   C "C2'" 1 
ATOM   4642 O "O2'" . G   C 2 58  ? -18.75400 -7.15000  3.22500   1.000 96.89541  ? 2570 G   C "O2'" 1 
ATOM   4643 C "C1'" . G   C 2 58  ? -18.26000 -5.08200  4.40300   1.000 100.14687 ? 2570 G   C "C1'" 1 
ATOM   4644 N N9    . G   C 2 58  ? -18.84900 -3.77200  4.64700   1.000 97.72077  ? 2570 G   C N9    1 
ATOM   4645 C C8    . G   C 2 58  ? -18.20900 -2.56000  4.67500   1.000 97.40367  ? 2570 G   C C8    1 
ATOM   4646 N N7    . G   C 2 58  ? -19.01500 -1.55900  4.93000   1.000 95.32914  ? 2570 G   C N7    1 
ATOM   4647 C C5    . G   C 2 58  ? -20.26300 -2.15000  5.07600   1.000 92.53009  ? 2570 G   C C5    1 
ATOM   4648 C C6    . G   C 2 58  ? -21.52200 -1.56700  5.36000   1.000 86.56335  ? 2570 G   C C6    1 
ATOM   4649 O O6    . G   C 2 58  ? -21.79900 -0.37500  5.54000   1.000 83.65850  ? 2570 G   C O6    1 
ATOM   4650 N N1    . G   C 2 58  ? -22.52400 -2.53300  5.41800   1.000 85.70335  ? 2570 G   C N1    1 
ATOM   4651 C C2    . G   C 2 58  ? -22.34400 -3.87900  5.22900   1.000 89.79070  ? 2570 G   C C2    1 
ATOM   4652 N N2    . G   C 2 58  ? -23.43500 -4.65000  5.32500   1.000 85.27335  ? 2570 G   C N2    1 
ATOM   4653 N N3    . G   C 2 58  ? -21.16400 -4.43200  4.96800   1.000 92.65394  ? 2570 G   C N3    1 
ATOM   4654 C C4    . G   C 2 58  ? -20.17300 -3.51200  4.90100   1.000 94.39852  ? 2570 G   C C4    1 
ATOM   4655 P P     . C   C 2 59  ? -18.26400 -5.29000  -0.45800  1.000 105.23052 ? 2571 C   C P     1 
ATOM   4656 O OP1   . C   C 2 59  ? -17.58000 -5.88500  -1.66400  1.000 108.84073 ? 2571 C   C OP1   1 
ATOM   4657 O OP2   . C   C 2 59  ? -18.20300 -3.77800  -0.40200  1.000 100.85593 ? 2571 C   C OP2   1 
ATOM   4658 O "O5'" . C   C 2 59  ? -19.81600 -5.68600  -0.55800  1.000 101.88202 ? 2571 C   C "O5'" 1 
ATOM   4659 C "C5'" . C   C 2 59  ? -20.26000 -6.93200  0.02500   1.000 99.25694  ? 2571 C   C "C5'" 1 
ATOM   4660 C "C4'" . C   C 2 59  ? -21.70100 -6.77600  0.43200   1.000 97.18083  ? 2571 C   C "C4'" 1 
ATOM   4661 O "O4'" . C   C 2 59  ? -21.78200 -6.00000  1.65300   1.000 95.51208  ? 2571 C   C "O4'" 1 
ATOM   4662 C "C3'" . C   C 2 59  ? -22.57900 -5.99900  -0.55400  1.000 95.00580  ? 2571 C   C "C3'" 1 
ATOM   4663 O "O3'" . C   C 2 59  ? -23.02300 -6.83300  -1.61600  1.000 95.35865  ? 2571 C   C "O3'" 1 
ATOM   4664 C "C2'" . C   C 2 59  ? -23.71900 -5.54300  0.35900   1.000 92.31725  ? 2571 C   C "C2'" 1 
ATOM   4665 O "O2'" . C   C 2 59  ? -24.66100 -6.56100  0.61500   1.000 87.63637  ? 2571 C   C "O2'" 1 
ATOM   4666 C "C1'" . C   C 2 59  ? -22.96500 -5.22800  1.65500   1.000 90.09919  ? 2571 C   C "C1'" 1 
ATOM   4667 N N1    . C   C 2 59  ? -22.60300 -3.79100  1.77100   1.000 88.22755  ? 2571 C   C N1    1 
ATOM   4668 C C2    . C   C 2 59  ? -23.59600 -2.89400  2.16500   1.000 83.72490  ? 2571 C   C C2    1 
ATOM   4669 O O2    . C   C 2 59  ? -24.73000 -3.32900  2.41200   1.000 80.40452  ? 2571 C   C O2    1 
ATOM   4670 N N3    . C   C 2 59  ? -23.28500 -1.58200  2.27700   1.000 81.03491  ? 2571 C   C N3    1 
ATOM   4671 C C4    . C   C 2 59  ? -22.04700 -1.15300  2.01400   1.000 81.24544  ? 2571 C   C C4    1 
ATOM   4672 N N4    . C   C 2 59  ? -21.80300 0.14200   2.13900   1.000 72.66460  ? 2571 C   C N4    1 
ATOM   4673 C C5    . C   C 2 59  ? -21.02400 -2.05300  1.61200   1.000 86.78610  ? 2571 C   C C5    1 
ATOM   4674 C C6    . C   C 2 59  ? -21.34100 -3.35000  1.50500   1.000 90.26125  ? 2571 C   C C6    1 
HETATM 4675 N N     . SAH D 3 .   ? -25.98300 38.55400  1.36600   1.000 41.59010  ? 301  SAH A N     1 
HETATM 4676 C CA    . SAH D 3 .   ? -25.01800 39.24200  2.24900   1.000 44.79870  ? 301  SAH A CA    1 
HETATM 4677 C CB    . SAH D 3 .   ? -23.64500 39.28400  1.58100   1.000 42.40332  ? 301  SAH A CB    1 
HETATM 4678 C CG    . SAH D 3 .   ? -22.46200 39.19000  2.50100   1.000 37.25455  ? 301  SAH A CG    1 
HETATM 4679 S SD    . SAH D 3 .   ? -20.97700 39.63800  1.58000   1.000 32.13025  ? 301  SAH A SD    1 
HETATM 4680 C C     . SAH D 3 .   ? -25.51500 40.66900  2.49100   1.000 47.96173  ? 301  SAH A C     1 
HETATM 4681 O O     . SAH D 3 .   ? -26.66300 40.94200  2.14800   1.000 52.52573  ? 301  SAH A O     1 
HETATM 4682 O OXT   . SAH D 3 .   ? -24.73900 41.43600  3.00700   1.000 43.99357  ? 301  SAH A OXT   1 
HETATM 4683 C "C5'" . SAH D 3 .   ? -19.78300 39.89800  2.90700   1.000 28.43562  ? 301  SAH A "C5'" 1 
HETATM 4684 C "C4'" . SAH D 3 .   ? -19.37700 41.34100  3.04600   1.000 24.80198  ? 301  SAH A "C4'" 1 
HETATM 4685 O "O4'" . SAH D 3 .   ? -18.66200 41.74400  1.86000   1.000 22.07843  ? 301  SAH A "O4'" 1 
HETATM 4686 C "C3'" . SAH D 3 .   ? -20.53100 42.32700  3.14700   1.000 26.23162  ? 301  SAH A "C3'" 1 
HETATM 4687 O "O3'" . SAH D 3 .   ? -20.99300 42.45600  4.48100   1.000 28.19409  ? 301  SAH A "O3'" 1 
HETATM 4688 C "C2'" . SAH D 3 .   ? -19.84900 43.61400  2.69100   1.000 25.45500  ? 301  SAH A "C2'" 1 
HETATM 4689 O "O2'" . SAH D 3 .   ? -19.11900 44.22100  3.73200   1.000 25.06845  ? 301  SAH A "O2'" 1 
HETATM 4690 C "C1'" . SAH D 3 .   ? -18.92300 43.10400  1.59100   1.000 25.30865  ? 301  SAH A "C1'" 1 
HETATM 4691 N N9    . SAH D 3 .   ? -19.46300 43.22500  0.24300   1.000 22.97445  ? 301  SAH A N9    1 
HETATM 4692 C C8    . SAH D 3 .   ? -19.63800 42.20900  -0.65900  1.000 25.67680  ? 301  SAH A C8    1 
HETATM 4693 N N7    . SAH D 3 .   ? -20.11900 42.60700  -1.80700  1.000 26.25119  ? 301  SAH A N7    1 
HETATM 4694 C C5    . SAH D 3 .   ? -20.26900 43.97500  -1.66000  1.000 23.77710  ? 301  SAH A C5    1 
HETATM 4695 C C6    . SAH D 3 .   ? -20.74000 44.97100  -2.53400  1.000 23.82862  ? 301  SAH A C6    1 
HETATM 4696 N N6    . SAH D 3 .   ? -21.16300 44.72700  -3.76900  1.000 27.37637  ? 301  SAH A N6    1 
HETATM 4697 N N1    . SAH D 3 .   ? -20.76500 46.24300  -2.07600  1.000 23.66312  ? 301  SAH A N1    1 
HETATM 4698 C C2    . SAH D 3 .   ? -20.33500 46.47700  -0.83300  1.000 23.77911  ? 301  SAH A C2    1 
HETATM 4699 N N3    . SAH D 3 .   ? -19.87800 45.62300  0.07600   1.000 23.36938  ? 301  SAH A N3    1 
HETATM 4700 C C4    . SAH D 3 .   ? -19.86900 44.37000  -0.40000  1.000 23.37679  ? 301  SAH A C4    1 
HETATM 4701 N N     . SAH E 3 .   ? 5.58400   37.46400  -9.24600  1.000 58.62707  ? 301  SAH B N     1 
HETATM 4702 C CA    . SAH E 3 .   ? 4.47600   37.32300  -10.22700 1.000 63.89879  ? 301  SAH B CA    1 
HETATM 4703 C CB    . SAH E 3 .   ? 3.13900   37.72000  -9.59700  1.000 56.21914  ? 301  SAH B CB    1 
HETATM 4704 C CG    . SAH E 3 .   ? 2.14900   36.57900  -9.52900  1.000 56.14319  ? 301  SAH B CG    1 
HETATM 4705 S SD    . SAH E 3 .   ? 0.47200   37.11000  -9.12300  1.000 68.58564  ? 301  SAH B SD    1 
HETATM 4706 C C     . SAH E 3 .   ? 4.74700   38.22100  -11.43900 1.000 64.70630  ? 301  SAH B C     1 
HETATM 4707 O O     . SAH E 3 .   ? 5.86200   38.77000  -11.50400 1.000 62.88020  ? 301  SAH B O     1 
HETATM 4708 O OXT   . SAH E 3 .   ? 3.82900   38.34100  -12.26700 1.000 58.28240  ? 301  SAH B OXT   1 
HETATM 4709 C "C5'" . SAH E 3 .   ? -0.46800  36.56900  -10.57100 1.000 49.80231  ? 301  SAH B "C5'" 1 
HETATM 4710 C "C4'" . SAH E 3 .   ? -0.77600  37.68700  -11.53000 1.000 43.69787  ? 301  SAH B "C4'" 1 
HETATM 4711 O "O4'" . SAH E 3 .   ? -1.43400  38.75100  -10.81200 1.000 38.79274  ? 301  SAH B "O4'" 1 
HETATM 4712 C "C3'" . SAH E 3 .   ? 0.45000   38.33200  -12.16000 1.000 47.59702  ? 301  SAH B "C3'" 1 
HETATM 4713 O "O3'" . SAH E 3 .   ? 0.80900   37.65300  -13.35600 1.000 51.99517  ? 301  SAH B "O3'" 1 
HETATM 4714 C "C2'" . SAH E 3 .   ? -0.03600  39.75000  -12.45900 1.000 45.12733  ? 301  SAH B "C2'" 1 
HETATM 4715 O "O2'" . SAH E 3 .   ? -0.60100  39.83900  -13.74800 1.000 49.42211  ? 301  SAH B "O2'" 1 
HETATM 4716 C "C1'" . SAH E 3 .   ? -1.08000  39.99600  -11.36900 1.000 43.86878  ? 301  SAH B "C1'" 1 
HETATM 4717 N N9    . SAH E 3 .   ? -0.63100  40.86800  -10.29000 1.000 39.83628  ? 301  SAH B N9    1 
HETATM 4718 C C8    . SAH E 3 .   ? -0.49200  40.53200  -8.96800  1.000 38.48351  ? 301  SAH B C8    1 
HETATM 4719 N N7    . SAH E 3 .   ? -0.08800  41.52400  -8.21800  1.000 34.59069  ? 301  SAH B N7    1 
HETATM 4720 C C5    . SAH E 3 .   ? 0.04200   42.58600  -9.10000  1.000 38.35328  ? 301  SAH B C5    1 
HETATM 4721 C C6    . SAH E 3 .   ? 0.44300   43.92200  -8.91500  1.000 35.23293  ? 301  SAH B C6    1 
HETATM 4722 N N6    . SAH E 3 .   ? 0.79400   44.43100  -7.73900  1.000 34.83324  ? 301  SAH B N6    1 
HETATM 4723 N N1    . SAH E 3 .   ? 0.46600   44.72100  -10.00700 1.000 32.87071  ? 301  SAH B N1    1 
HETATM 4724 C C2    . SAH E 3 .   ? 0.10200   44.20400  -11.18600 1.000 35.68583  ? 301  SAH B C2    1 
HETATM 4725 N N3    . SAH E 3 .   ? -0.28500  42.96800  -11.47900 1.000 32.77327  ? 301  SAH B N3    1 
HETATM 4726 C C4    . SAH E 3 .   ? -0.29400  42.19600  -10.38100 1.000 35.73251  ? 301  SAH B C4    1 
HETATM 4727 O O     . HOH F 4 .   ? -5.96300  59.82700  13.77000  1.000 47.89623  ? 401  HOH A O     1 
HETATM 4728 O O     . HOH F 4 .   ? -30.43100 48.32100  6.77500   1.000 53.83970  ? 402  HOH A O     1 
HETATM 4729 O O     . HOH F 4 .   ? -8.43800  54.47600  21.91300  1.000 49.74204  ? 403  HOH A O     1 
HETATM 4730 O O     . HOH F 4 .   ? 19.70900  26.37600  18.44100  1.000 54.99715  ? 404  HOH A O     1 
HETATM 4731 O O     . HOH F 4 .   ? 13.61500  38.78800  4.50500   1.000 38.61304  ? 405  HOH A O     1 
HETATM 4732 O O     . HOH F 4 .   ? -23.92000 43.80800  16.21300  1.000 48.03065  ? 406  HOH A O     1 
HETATM 4733 O O     . HOH F 4 .   ? 6.74000   15.82000  3.26200   1.000 64.94241  ? 407  HOH A O     1 
HETATM 4734 O O     . HOH F 4 .   ? -18.15000 29.38800  7.82600   1.000 35.12495  ? 408  HOH A O     1 
HETATM 4735 O O     . HOH F 4 .   ? -28.17600 52.45000  2.26300   1.000 45.25600  ? 409  HOH A O     1 
HETATM 4736 O O     . HOH F 4 .   ? 12.23600  37.15800  15.85700  1.000 45.18887  ? 410  HOH A O     1 
HETATM 4737 O O     . HOH F 4 .   ? 11.047    8.813     17.413    1.000 80.67915  ? 411  HOH A O     1 
HETATM 4738 O O     . HOH F 4 .   ? -26.58600 42.05200  7.11300   1.000 45.87997  ? 412  HOH A O     1 
HETATM 4739 O O     . HOH F 4 .   ? 3.52500   42.81900  6.09200   1.000 41.21773  ? 413  HOH A O     1 
HETATM 4740 O O     . HOH F 4 .   ? 6.44200   37.63100  2.74300   1.000 48.68301  ? 414  HOH A O     1 
HETATM 4741 O O     . HOH F 4 .   ? -0.157    54.199    13.708    1.000 50.72428  ? 415  HOH A O     1 
HETATM 4742 O O     . HOH F 4 .   ? -4.20600  31.16900  17.75900  1.000 40.14277  ? 416  HOH A O     1 
HETATM 4743 O O     . HOH F 4 .   ? -10.11600 50.89300  23.64600  1.000 39.60591  ? 417  HOH A O     1 
HETATM 4744 O O     . HOH F 4 .   ? -4.41300  55.52500  21.01100  1.000 57.12326  ? 418  HOH A O     1 
HETATM 4745 O O     . HOH F 4 .   ? -27.60500 43.03800  1.18000   1.000 41.54199  ? 419  HOH A O     1 
HETATM 4746 O O     . HOH F 4 .   ? -24.30200 46.52100  -5.07600  1.000 35.10008  ? 420  HOH A O     1 
HETATM 4747 O O     . HOH F 4 .   ? -11.31100 65.85100  1.38100   1.000 50.38430  ? 421  HOH A O     1 
HETATM 4748 O O     . HOH F 4 .   ? 21.12200  30.99600  14.76100  1.000 43.73915  ? 422  HOH A O     1 
HETATM 4749 O O     . HOH F 4 .   ? -31.08600 49.53700  12.30400  1.000 61.31867  ? 423  HOH A O     1 
HETATM 4750 O O     . HOH F 4 .   ? -5.331    35.387    17.501    1.000 49.70329  ? 424  HOH A O     1 
HETATM 4751 O O     . HOH F 4 .   ? -27.00800 56.15100  10.46600  1.000 49.96459  ? 425  HOH A O     1 
HETATM 4752 O O     . HOH F 4 .   ? 19.28600  19.26800  2.86400   1.000 55.25538  ? 426  HOH A O     1 
HETATM 4753 O O     . HOH F 4 .   ? 7.14400   18.92800  0.10900   1.000 61.80104  ? 427  HOH A O     1 
HETATM 4754 O O     . HOH F 4 .   ? -22.34700 52.17300  -11.20700 1.000 52.42340  ? 428  HOH A O     1 
HETATM 4755 O O     . HOH F 4 .   ? 3.32500   22.20300  21.25400  1.000 60.25013  ? 429  HOH A O     1 
HETATM 4756 O O     . HOH F 4 .   ? 15.23500  11.01100  8.24300   1.000 77.26237  ? 430  HOH A O     1 
HETATM 4757 O O     . HOH F 4 .   ? 13.65400  33.06600  1.08900   1.000 40.20615  ? 431  HOH A O     1 
HETATM 4758 O O     . HOH F 4 .   ? -20.61300 40.79200  10.13000  1.000 36.87560  ? 432  HOH A O     1 
HETATM 4759 O O     . HOH F 4 .   ? 2.38700   29.45400  5.29900   1.000 39.29097  ? 433  HOH A O     1 
HETATM 4760 O O     . HOH F 4 .   ? -6.08600  43.31300  20.11300  1.000 31.29672  ? 434  HOH A O     1 
HETATM 4761 O O     . HOH F 4 .   ? 4.10700   24.30800  0.02300   1.000 52.92732  ? 435  HOH A O     1 
HETATM 4762 O O     . HOH F 4 .   ? -19.73000 35.41400  11.79100  1.000 46.46789  ? 436  HOH A O     1 
HETATM 4763 O O     . HOH F 4 .   ? 4.07400   36.19700  23.67700  1.000 48.23464  ? 437  HOH A O     1 
HETATM 4764 O O     . HOH F 4 .   ? -26.94400 42.94800  4.92900   1.000 46.86263  ? 438  HOH A O     1 
HETATM 4765 O O     . HOH F 4 .   ? -0.43100  26.35800  14.28400  1.000 42.53824  ? 439  HOH A O     1 
HETATM 4766 O O     . HOH F 4 .   ? -2.931    25.367    29.356    1.000 51.44294  ? 440  HOH A O     1 
HETATM 4767 O O     . HOH F 4 .   ? -11.65800 52.47600  -7.53800  1.000 23.28226  ? 441  HOH A O     1 
HETATM 4768 O O     . HOH F 4 .   ? -4.61600  24.69200  6.85000   1.000 50.40627  ? 442  HOH A O     1 
HETATM 4769 O O     . HOH F 4 .   ? 6.76700   43.43400  14.76500  1.000 51.63004  ? 443  HOH A O     1 
HETATM 4770 O O     . HOH F 4 .   ? -20.14800 34.28200  9.74900   1.000 45.62181  ? 444  HOH A O     1 
HETATM 4771 O O     . HOH F 4 .   ? 1.66000   33.78900  24.08400  1.000 47.26810  ? 445  HOH A O     1 
HETATM 4772 O O     . HOH F 4 .   ? -23.46600 43.51800  4.43600   1.000 27.69836  ? 446  HOH A O     1 
HETATM 4773 O O     . HOH F 4 .   ? -12.15200 61.63500  4.19600   1.000 35.78026  ? 447  HOH A O     1 
HETATM 4774 O O     . HOH F 4 .   ? -29.61400 49.60000  9.97900   1.000 53.80064  ? 448  HOH A O     1 
HETATM 4775 O O     . HOH F 4 .   ? 2.06900   31.89400  0.79100   1.000 46.21129  ? 449  HOH A O     1 
HETATM 4776 O O     . HOH F 4 .   ? -1.95200  56.57300  11.34100  1.000 42.96866  ? 450  HOH A O     1 
HETATM 4777 O O     . HOH F 4 .   ? 6.66700   35.51700  20.05300  1.000 34.93264  ? 451  HOH A O     1 
HETATM 4778 O O     . HOH F 4 .   ? -17.395   42.025    25.068    1.000 46.30345  ? 452  HOH A O     1 
HETATM 4779 O O     . HOH F 4 .   ? -4.45900  23.39700  3.46700   1.000 59.64176  ? 453  HOH A O     1 
HETATM 4780 O O     . HOH F 4 .   ? -9.03800  36.82100  14.73000  1.000 36.68218  ? 454  HOH A O     1 
HETATM 4781 O O     . HOH F 4 .   ? -21.95300 40.34300  15.25100  1.000 55.64136  ? 455  HOH A O     1 
HETATM 4782 O O     . HOH F 4 .   ? 21.35300  27.24100  14.33000  1.000 47.15239  ? 456  HOH A O     1 
HETATM 4783 O O     . HOH F 4 .   ? -3.00900  56.26700  3.32700   1.000 40.40534  ? 457  HOH A O     1 
HETATM 4784 O O     . HOH F 4 .   ? 1.67900   48.22200  4.34900   1.000 31.63050  ? 458  HOH A O     1 
HETATM 4785 O O     . HOH F 4 .   ? -10.67300 30.44100  14.39500  1.000 45.23569  ? 459  HOH A O     1 
HETATM 4786 O O     . HOH F 4 .   ? -26.04600 51.80300  15.64600  1.000 52.02182  ? 460  HOH A O     1 
HETATM 4787 O O     . HOH F 4 .   ? -0.90700  28.40500  12.65000  1.000 37.55850  ? 461  HOH A O     1 
HETATM 4788 O O     . HOH F 4 .   ? 0.46900   28.17100  7.16300   1.000 32.97469  ? 462  HOH A O     1 
HETATM 4789 O O     . HOH F 4 .   ? -10.35800 29.65700  3.85800   1.000 34.40676  ? 463  HOH A O     1 
HETATM 4790 O O     . HOH F 4 .   ? -28.58100 38.99200  2.29600   1.000 51.18131  ? 464  HOH A O     1 
HETATM 4791 O O     . HOH F 4 .   ? 1.02000   20.44900  27.92000  1.000 65.60901  ? 465  HOH A O     1 
HETATM 4792 O O     . HOH F 4 .   ? -26.74800 36.14900  2.61300   1.000 55.72686  ? 466  HOH A O     1 
HETATM 4793 O O     . HOH F 4 .   ? 2.96900   45.41900  -0.13400  1.000 31.13109  ? 467  HOH A O     1 
HETATM 4794 O O     . HOH F 4 .   ? -11.37600 50.03100  -6.29700  1.000 23.52169  ? 468  HOH A O     1 
HETATM 4795 O O     . HOH F 4 .   ? -20.93800 56.36900  14.78100  1.000 55.98055  ? 469  HOH A O     1 
HETATM 4796 O O     . HOH F 4 .   ? -7.04900  63.88900  -4.25700  1.000 31.78702  ? 470  HOH A O     1 
HETATM 4797 O O     . HOH F 4 .   ? 17.05000  34.02900  13.98500  1.000 50.25669  ? 471  HOH A O     1 
HETATM 4798 O O     . HOH F 4 .   ? 8.64400   38.23400  21.00800  1.000 46.25420  ? 472  HOH A O     1 
HETATM 4799 O O     . HOH F 4 .   ? -10.72600 36.03100  -1.47900  1.000 40.44040  ? 473  HOH A O     1 
HETATM 4800 O O     . HOH F 4 .   ? 0.60900   26.24400  5.41000   1.000 45.42555  ? 474  HOH A O     1 
HETATM 4801 O O     . HOH F 4 .   ? -22.70400 40.56700  -10.43700 1.000 31.16981  ? 475  HOH A O     1 
HETATM 4802 O O     . HOH F 4 .   ? -28.17600 38.83300  5.69600   1.000 55.37581  ? 476  HOH A O     1 
HETATM 4803 O O     . HOH F 4 .   ? 11.12200  43.62800  14.41300  1.000 51.25635  ? 477  HOH A O     1 
HETATM 4804 O O     . HOH F 4 .   ? -24.28700 60.81000  7.81300   1.000 51.01502  ? 478  HOH A O     1 
HETATM 4805 O O     . HOH F 4 .   ? 0.49200   47.70400  19.80200  1.000 44.31913  ? 479  HOH A O     1 
HETATM 4806 O O     . HOH F 4 .   ? -22.89100 41.58700  -17.14900 1.000 49.56258  ? 480  HOH A O     1 
HETATM 4807 O O     . HOH F 4 .   ? 1.19700   24.49600  9.29100   1.000 46.18737  ? 481  HOH A O     1 
HETATM 4808 O O     . HOH F 4 .   ? -27.90600 44.72300  14.49900  1.000 49.50733  ? 482  HOH A O     1 
HETATM 4809 O O     . HOH F 4 .   ? 3.75200   29.10900  25.28300  1.000 56.19016  ? 483  HOH A O     1 
HETATM 4810 O O     . HOH F 4 .   ? -18.34700 62.06400  1.22600   1.000 36.62718  ? 484  HOH A O     1 
HETATM 4811 O O     . HOH F 4 .   ? -7.88700  35.69200  16.57000  1.000 45.24959  ? 485  HOH A O     1 
HETATM 4812 O O     . HOH F 4 .   ? -19.09200 49.15000  25.45100  1.000 45.82983  ? 486  HOH A O     1 
HETATM 4813 O O     . HOH F 4 .   ? 4.57600   39.26700  22.44900  1.000 50.46319  ? 487  HOH A O     1 
HETATM 4814 O O     . HOH F 4 .   ? 19.33900  18.97300  14.72800  1.000 59.81842  ? 488  HOH A O     1 
HETATM 4815 O O     . HOH F 4 .   ? 0.67300   16.82900  4.45300   1.000 56.50635  ? 489  HOH A O     1 
HETATM 4816 O O     . HOH F 4 .   ? -25.81200 40.30400  -1.32500  1.000 39.32597  ? 490  HOH A O     1 
HETATM 4817 O O     . HOH F 4 .   ? 1.42100   27.66100  9.58000   1.000 41.61600  ? 491  HOH A O     1 
HETATM 4818 O O     . HOH F 4 .   ? -8.79300  25.34700  14.35000  1.000 45.06108  ? 492  HOH A O     1 
HETATM 4819 O O     . HOH F 4 .   ? -9.64500  33.54600  21.60200  1.000 59.61222  ? 493  HOH A O     1 
HETATM 4820 O O     . HOH F 4 .   ? 15.46100  6.14400   8.61700   1.000 94.69903  ? 494  HOH A O     1 
HETATM 4821 O O     . HOH F 4 .   ? -7.45800  58.40300  14.98600  1.000 52.11251  ? 495  HOH A O     1 
HETATM 4822 O O     . HOH F 4 .   ? -9.54200  24.04100  17.48800  1.000 48.15235  ? 496  HOH A O     1 
HETATM 4823 O O     . HOH F 4 .   ? 7.87100   40.56900  9.08600   1.000 34.24706  ? 497  HOH A O     1 
HETATM 4824 O O     . HOH F 4 .   ? -12.12100 50.96000  25.70500  1.000 41.96510  ? 498  HOH A O     1 
HETATM 4825 O O     . HOH F 4 .   ? 2.46700   46.57200  13.27700  1.000 51.77597  ? 499  HOH A O     1 
HETATM 4826 O O     . HOH F 4 .   ? 0.08000   62.43600  -5.23700  1.000 29.44276  ? 500  HOH A O     1 
HETATM 4827 O O     . HOH F 4 .   ? 8.48500   30.23000  1.34500   1.000 40.38156  ? 501  HOH A O     1 
HETATM 4828 O O     . HOH F 4 .   ? 0.28000   51.78400  11.50200  1.000 47.38492  ? 502  HOH A O     1 
HETATM 4829 O O     . HOH F 4 .   ? -28.42800 35.79900  -10.50000 1.000 47.03432  ? 503  HOH A O     1 
HETATM 4830 O O     . HOH F 4 .   ? -7.94200  59.10300  -10.88000 1.000 27.22247  ? 504  HOH A O     1 
HETATM 4831 O O     . HOH F 4 .   ? -25.19400 46.89000  -7.82000  1.000 36.51724  ? 505  HOH A O     1 
HETATM 4832 O O     . HOH F 4 .   ? -28.53300 42.56800  11.92600  1.000 47.45181  ? 506  HOH A O     1 
HETATM 4833 O O     . HOH F 4 .   ? -27.37200 49.88000  4.07500   1.000 45.53146  ? 507  HOH A O     1 
HETATM 4834 O O     . HOH F 4 .   ? 12.52300  40.08400  1.61000   1.000 46.32741  ? 508  HOH A O     1 
HETATM 4835 O O     . HOH F 4 .   ? -6.91900  26.85700  13.13100  1.000 40.58426  ? 509  HOH A O     1 
HETATM 4836 O O     . HOH F 4 .   ? -3.16000  26.18700  2.83000   1.000 51.86353  ? 510  HOH A O     1 
HETATM 4837 O O     . HOH F 4 .   ? -19.53000 33.96900  7.25300   1.000 32.25950  ? 511  HOH A O     1 
HETATM 4838 O O     . HOH F 4 .   ? -11.03000 38.22700  16.13900  1.000 31.38625  ? 512  HOH A O     1 
HETATM 4839 O O     . HOH F 4 .   ? 3.19300   38.51100  -1.24100  1.000 44.94598  ? 513  HOH A O     1 
HETATM 4840 O O     . HOH F 4 .   ? 0.40300   49.33700  15.32800  1.000 43.35260  ? 514  HOH A O     1 
HETATM 4841 O O     . HOH F 4 .   ? -13.22300 61.57700  6.75100   1.000 37.40719  ? 515  HOH A O     1 
HETATM 4842 O O     . HOH F 4 .   ? 20.85300  21.38700  3.98900   1.000 53.11954  ? 516  HOH A O     1 
HETATM 4843 O O     . HOH F 4 .   ? -25.93900 57.74100  8.85600   1.000 48.13169  ? 517  HOH A O     1 
HETATM 4844 O O     . HOH F 4 .   ? -24.98300 49.86500  -8.60600  1.000 41.85505  ? 518  HOH A O     1 
HETATM 4845 O O     . HOH F 4 .   ? -13.62600 39.17800  11.61700  1.000 30.30618  ? 519  HOH A O     1 
HETATM 4846 O O     . HOH F 4 .   ? -11.88100 36.90200  11.15400  1.000 41.71082  ? 520  HOH A O     1 
HETATM 4847 O O     . HOH F 4 .   ? 2.72300   22.43800  26.46000  1.000 62.30448  ? 521  HOH A O     1 
HETATM 4848 O O     . HOH F 4 .   ? -8.96400  63.44100  8.92100   1.000 44.81104  ? 522  HOH A O     1 
HETATM 4849 O O     . HOH F 4 .   ? -19.35700 49.20100  22.51400  1.000 41.83964  ? 523  HOH A O     1 
HETATM 4850 O O     . HOH F 4 .   ? 2.69700   39.61000  15.23000  1.000 40.82339  ? 524  HOH A O     1 
HETATM 4851 O O     . HOH F 4 .   ? 2.30200   44.62500  22.79600  1.000 57.04544  ? 525  HOH A O     1 
HETATM 4852 O O     . HOH F 4 .   ? 0.22100   40.37500  14.33800  1.000 41.05950  ? 526  HOH A O     1 
HETATM 4853 O O     . HOH F 4 .   ? -0.044    54.860    11.250    1.000 40.27569  ? 527  HOH A O     1 
HETATM 4854 O O     . HOH F 4 .   ? -6.13200  24.40900  10.69600  1.000 45.80039  ? 528  HOH A O     1 
HETATM 4855 O O     . HOH F 4 .   ? -12.87800 38.37600  18.80800  1.000 45.30850  ? 529  HOH A O     1 
HETATM 4856 O O     . HOH F 4 .   ? -7.63100  33.97900  -1.82900  1.000 36.46789  ? 530  HOH A O     1 
HETATM 4857 O O     . HOH F 4 .   ? -7.70600  65.19400  -8.95600  1.000 43.17928  ? 531  HOH A O     1 
HETATM 4858 O O     . HOH F 4 .   ? -15.87100 38.64800  -5.91800  1.000 25.11156  ? 532  HOH A O     1 
HETATM 4859 O O     . HOH F 4 .   ? 5.44500   29.40100  1.41300   1.000 47.88607  ? 533  HOH A O     1 
HETATM 4860 O O     . HOH F 4 .   ? 12.96500  11.46000  4.61400   1.000 54.84950  ? 534  HOH A O     1 
HETATM 4861 O O     . HOH F 4 .   ? 2.12300   29.36700  -0.15900  1.000 47.49739  ? 535  HOH A O     1 
HETATM 4862 O O     . HOH F 4 .   ? 7.90400   24.00700  20.75800  1.000 51.39990  ? 536  HOH A O     1 
HETATM 4863 O O     . HOH F 4 .   ? 9.97700   20.43200  -1.01000  1.000 57.22000  ? 537  HOH A O     1 
HETATM 4864 O O     . HOH F 4 .   ? 15.44000  32.19700  18.23500  1.000 52.51217  ? 538  HOH A O     1 
HETATM 4865 O O     . HOH F 4 .   ? -1.69100  63.25200  -3.32500  1.000 30.50785  ? 539  HOH A O     1 
HETATM 4866 O O     . HOH F 4 .   ? -18.46700 52.95200  16.94500  1.000 47.30139  ? 540  HOH A O     1 
HETATM 4867 O O     . HOH F 4 .   ? 0.73500   48.46000  6.71900   1.000 40.65659  ? 541  HOH A O     1 
HETATM 4868 O O     . HOH F 4 .   ? -17.291   60.195    2.518     1.000 46.25011  ? 542  HOH A O     1 
HETATM 4869 O O     . HOH F 4 .   ? 13.55500  34.04400  18.28600  1.000 48.82602  ? 543  HOH A O     1 
HETATM 4870 O O     . HOH F 4 .   ? 11.59900  12.94800  19.52300  1.000 75.00096  ? 544  HOH A O     1 
HETATM 4871 O O     . HOH F 4 .   ? -27.06500 44.69100  -8.84800  1.000 49.66125  ? 545  HOH A O     1 
HETATM 4872 O O     . HOH F 4 .   ? -6.94000  64.88200  4.43500   1.000 47.26273  ? 546  HOH A O     1 
HETATM 4873 O O     . HOH F 4 .   ? -26.95900 43.08800  -12.33100 1.000 49.03024  ? 547  HOH A O     1 
HETATM 4874 O O     . HOH F 4 .   ? -19.43400 57.31800  11.58900  1.000 44.19502  ? 548  HOH A O     1 
HETATM 4875 O O     . HOH F 4 .   ? 21.51700  28.86300  16.18000  1.000 44.81060  ? 549  HOH A O     1 
HETATM 4876 O O     . HOH F 4 .   ? -24.89500 48.73600  -11.05400 1.000 53.47778  ? 550  HOH A O     1 
HETATM 4877 O O     . HOH F 4 .   ? -10.82700 33.54700  17.07400  1.000 46.05730  ? 551  HOH A O     1 
HETATM 4878 O O     . HOH F 4 .   ? -8.81000  62.06300  -10.74100 1.000 23.35341  ? 552  HOH A O     1 
HETATM 4879 O O     . HOH F 4 .   ? 1.63200   34.14500  -4.31300  1.000 57.86898  ? 553  HOH A O     1 
HETATM 4880 O O     . HOH F 4 .   ? 16.05900  33.56300  -0.18400  1.000 34.71244  ? 554  HOH A O     1 
HETATM 4881 O O     . HOH F 4 .   ? -15.85600 65.43200  1.52600   1.000 53.05043  ? 555  HOH A O     1 
HETATM 4882 O O     . HOH F 4 .   ? -5.37300  19.40000  18.45400  1.000 55.09830  ? 556  HOH A O     1 
HETATM 4883 O O     . HOH F 4 .   ? -0.02400  22.75500  -1.27400  1.000 53.43480  ? 557  HOH A O     1 
HETATM 4884 O O     . HOH F 4 .   ? 0.91100   35.29800  -6.31600  1.000 60.27664  ? 558  HOH A O     1 
HETATM 4885 O O     . HOH F 4 .   ? 9.77800   26.02400  2.63100   1.000 34.05714  ? 559  HOH A O     1 
HETATM 4886 O O     . HOH F 4 .   ? 2.53900   20.10300  22.65900  1.000 63.40930  ? 560  HOH A O     1 
HETATM 4887 O O     . HOH F 4 .   ? 11.76200  30.49900  -0.19400  1.000 52.45027  ? 561  HOH A O     1 
HETATM 4888 O O     . HOH F 4 .   ? 6.99600   23.66400  -0.64700  1.000 60.19638  ? 562  HOH A O     1 
HETATM 4889 O O     . HOH F 4 .   ? 4.14100   40.82700  17.44000  1.000 45.61556  ? 563  HOH A O     1 
HETATM 4890 O O     . HOH F 4 .   ? 20.75500  21.28400  17.15100  1.000 62.69638  ? 564  HOH A O     1 
HETATM 4891 O O     . HOH F 4 .   ? 1.46700   50.67900  8.23100   1.000 50.56531  ? 565  HOH A O     1 
HETATM 4892 O O     . HOH F 4 .   ? 8.83800   42.96400  10.38200  1.000 38.35216  ? 566  HOH A O     1 
HETATM 4893 O O     . HOH F 4 .   ? -29.35100 40.85900  4.31400   1.000 58.27219  ? 567  HOH A O     1 
HETATM 4894 O O     . HOH F 4 .   ? 5.94800   21.85800  20.23800  1.000 59.80608  ? 568  HOH A O     1 
HETATM 4895 O O     . HOH F 4 .   ? -7.90100  28.86400  3.15600   1.000 44.47756  ? 569  HOH A O     1 
HETATM 4896 O O     . HOH F 4 .   ? -28.42800 51.73900  8.38500   1.000 47.35031  ? 570  HOH A O     1 
HETATM 4897 O O     . HOH F 4 .   ? -11.92200 27.42200  24.82400  1.000 60.59115  ? 571  HOH A O     1 
HETATM 4898 O O     . HOH F 4 .   ? -12.78300 35.74400  18.09100  1.000 52.97270  ? 572  HOH A O     1 
HETATM 4899 O O     . HOH F 4 .   ? 23.72000  18.95600  12.34100  1.000 60.32509  ? 573  HOH A O     1 
HETATM 4900 O O     . HOH F 4 .   ? -19.67200 50.46700  -17.81500 1.000 45.73960  ? 574  HOH A O     1 
HETATM 4901 O O     . HOH F 4 .   ? -1.87900  58.87700  9.27900   1.000 44.76663  ? 575  HOH A O     1 
HETATM 4902 O O     . HOH F 4 .   ? -2.60500  26.43200  5.24700   1.000 40.61232  ? 576  HOH A O     1 
HETATM 4903 O O     . HOH F 4 .   ? -7.39300  22.12000  24.57400  1.000 52.83426  ? 577  HOH A O     1 
HETATM 4904 O O     . HOH F 4 .   ? 18.48700  34.98600  17.52100  1.000 56.37713  ? 578  HOH A O     1 
HETATM 4905 O O     . HOH F 4 .   ? -7.59100  60.54200  18.52200  1.000 58.12251  ? 579  HOH A O     1 
HETATM 4906 O O     . HOH F 4 .   ? -29.001   54.492    8.442     1.000 50.34875  ? 580  HOH A O     1 
HETATM 4907 O O     . HOH F 4 .   ? 2.83900   47.40100  8.36700   1.000 44.71767  ? 581  HOH A O     1 
HETATM 4908 O O     . HOH F 4 .   ? -27.51500 41.99800  -2.14100  1.000 43.26473  ? 582  HOH A O     1 
HETATM 4909 O O     . HOH F 4 .   ? 6.13100   28.31200  25.18400  1.000 53.93267  ? 583  HOH A O     1 
HETATM 4910 O O     . HOH F 4 .   ? -28.68400 38.86200  -6.91000  1.000 53.37688  ? 584  HOH A O     1 
HETATM 4911 O O     . HOH F 4 .   ? 20.39800  24.86700  21.34600  1.000 63.81945  ? 585  HOH A O     1 
HETATM 4912 O O     . HOH F 4 .   ? -19.56100 51.45800  21.87200  1.000 49.07951  ? 586  HOH A O     1 
HETATM 4913 O O     . HOH F 4 .   ? -4.04600  64.93700  -3.74500  1.000 39.97597  ? 587  HOH A O     1 
HETATM 4914 O O     . HOH F 4 .   ? -29.931   55.256    6.270     1.000 52.59603  ? 588  HOH A O     1 
HETATM 4915 O O     . HOH F 4 .   ? 6.09700   38.37100  20.34100  1.000 35.70414  ? 589  HOH A O     1 
HETATM 4916 O O     . HOH F 4 .   ? -28.77800 50.45700  6.25400   1.000 46.59366  ? 590  HOH A O     1 
HETATM 4917 O O     . HOH F 4 .   ? -4.44300  23.31300  9.07500   1.000 49.84683  ? 591  HOH A O     1 
HETATM 4918 O O     . HOH F 4 .   ? 7.46600   44.12400  12.31200  1.000 46.89539  ? 592  HOH A O     1 
HETATM 4919 O O     . HOH F 4 .   ? 6.65200   31.21500  -0.24100  1.000 53.46070  ? 593  HOH A O     1 
HETATM 4920 O O     . HOH F 4 .   ? 2.02600   50.36400  11.26500  1.000 46.85433  ? 594  HOH A O     1 
HETATM 4921 O O     . HOH F 4 .   ? 5.64300   34.01500  -0.77400  1.000 56.68234  ? 595  HOH A O     1 
HETATM 4922 O O     . HOH F 4 .   ? 3.76700   34.01700  -2.94900  1.000 59.52878  ? 596  HOH A O     1 
HETATM 4923 O O     . HOH F 4 .   ? 16.05900  34.54900  16.63200  1.000 57.61757  ? 597  HOH A O     1 
HETATM 4924 O O     . HOH F 4 .   ? -28.36200 38.33000  10.78500  1.000 57.73271  ? 598  HOH A O     1 
HETATM 4925 O O     . HOH F 4 .   ? -37.01700 40.42800  7.83000   1.000 67.06641  ? 599  HOH A O     1 
HETATM 4926 O O     . HOH G 4 .   ? -4.76100  24.56400  -21.93800 1.000 44.60538  ? 401  HOH B O     1 
HETATM 4927 O O     . HOH G 4 .   ? -9.80700  58.32900  -23.70300 1.000 50.55453  ? 402  HOH B O     1 
HETATM 4928 O O     . HOH G 4 .   ? -36.12100 15.10100  -0.09100  1.000 46.65337  ? 403  HOH B O     1 
HETATM 4929 O O     . HOH G 4 .   ? -37.86900 15.71800  -1.52600  1.000 51.38242  ? 404  HOH B O     1 
HETATM 4930 O O     . HOH G 4 .   ? -17.38300 44.86100  -32.44400 1.000 50.47623  ? 405  HOH B O     1 
HETATM 4931 O O     . HOH G 4 .   ? -32.34900 32.85500  -8.17100  1.000 40.82702  ? 406  HOH B O     1 
HETATM 4932 O O     . HOH G 4 .   ? -16.47100 17.61300  8.40800   1.000 60.47307  ? 407  HOH B O     1 
HETATM 4933 O O     . HOH G 4 .   ? -31.92300 29.79400  -2.70700  1.000 40.35212  ? 408  HOH B O     1 
HETATM 4934 O O     . HOH G 4 .   ? 0.85300   32.84700  -16.33500 1.000 52.96854  ? 409  HOH B O     1 
HETATM 4935 O O     . HOH G 4 .   ? -40.20300 21.74800  -12.67800 1.000 47.81571  ? 410  HOH B O     1 
HETATM 4936 O O     . HOH G 4 .   ? 3.98900   47.37200  -27.66000 1.000 51.02488  ? 411  HOH B O     1 
HETATM 4937 O O     . HOH G 4 .   ? -4.79900  46.42000  -32.46600 1.000 44.56326  ? 412  HOH B O     1 
HETATM 4938 O O     . HOH G 4 .   ? -18.91000 13.39600  1.05000   1.000 47.40925  ? 413  HOH B O     1 
HETATM 4939 O O     . HOH G 4 .   ? -23.08700 33.70200  -21.53100 1.000 49.20878  ? 414  HOH B O     1 
HETATM 4940 O O     . HOH G 4 .   ? -20.43900 31.68800  -28.49100 1.000 53.70798  ? 415  HOH B O     1 
HETATM 4941 O O     . HOH G 4 .   ? -0.79300  33.65600  -3.92800  1.000 52.74672  ? 416  HOH B O     1 
HETATM 4942 O O     . HOH G 4 .   ? -32.93900 7.90900   3.84000   1.000 53.67735  ? 417  HOH B O     1 
HETATM 4943 O O     . HOH G 4 .   ? 6.23500   35.84100  -16.72900 1.000 63.11891  ? 418  HOH B O     1 
HETATM 4944 O O     . HOH G 4 .   ? -38.61200 18.64200  -2.40900  1.000 42.58236  ? 419  HOH B O     1 
HETATM 4945 O O     . HOH G 4 .   ? -19.89000 29.91800  -19.44700 1.000 47.62824  ? 420  HOH B O     1 
HETATM 4946 O O     . HOH G 4 .   ? -6.61200  62.09900  -16.57700 1.000 30.67126  ? 421  HOH B O     1 
HETATM 4947 O O     . HOH G 4 .   ? -21.85800 7.55700   2.57100   1.000 49.16080  ? 422  HOH B O     1 
HETATM 4948 O O     . HOH G 4 .   ? -13.81500 28.48300  -26.76800 1.000 38.94585  ? 423  HOH B O     1 
HETATM 4949 O O     . HOH G 4 .   ? -21.36400 8.59700   -14.92800 1.000 44.98633  ? 424  HOH B O     1 
HETATM 4950 O O     . HOH G 4 .   ? 0.32400   28.85400  -15.77600 1.000 54.84334  ? 425  HOH B O     1 
HETATM 4951 O O     . HOH G 4 .   ? -22.49900 35.12500  -14.90100 1.000 40.92447  ? 426  HOH B O     1 
HETATM 4952 O O     . HOH G 4 .   ? -22.48100 28.02200  -19.30000 1.000 39.43629  ? 427  HOH B O     1 
HETATM 4953 O O     . HOH G 4 .   ? -1.03600  29.73600  -9.45300  1.000 52.72928  ? 428  HOH B O     1 
HETATM 4954 O O     . HOH G 4 .   ? -12.01800 13.09000  -7.70300  1.000 57.68892  ? 429  HOH B O     1 
HETATM 4955 O O     . HOH G 4 .   ? -5.33300  51.90200  -23.19900 1.000 47.30107  ? 430  HOH B O     1 
HETATM 4956 O O     . HOH G 4 .   ? -21.83700 25.96700  -3.45100  1.000 39.27918  ? 431  HOH B O     1 
HETATM 4957 O O     . HOH G 4 .   ? -19.25300 38.30100  -25.21100 1.000 44.76508  ? 432  HOH B O     1 
HETATM 4958 O O     . HOH G 4 .   ? -1.63800  53.91200  2.41500   1.000 38.92120  ? 433  HOH B O     1 
HETATM 4959 O O     . HOH G 4 .   ? -23.51400 21.31700  4.45500   1.000 47.03953  ? 434  HOH B O     1 
HETATM 4960 O O     . HOH G 4 .   ? -5.24100  44.37000  -30.28600 1.000 40.54887  ? 435  HOH B O     1 
HETATM 4961 O O     . HOH G 4 .   ? -30.91500 13.70100  7.50700   1.000 56.10885  ? 436  HOH B O     1 
HETATM 4962 O O     . HOH G 4 .   ? -24.11000 36.66000  -19.63200 1.000 53.63611  ? 437  HOH B O     1 
HETATM 4963 O O     . HOH G 4 .   ? -36.703   24.608    -13.512   1.000 43.36680  ? 438  HOH B O     1 
HETATM 4964 O O     . HOH G 4 .   ? -6.02500  30.36900  -18.60100 1.000 34.62800  ? 439  HOH B O     1 
HETATM 4965 O O     . HOH G 4 .   ? -4.92100  39.92300  -1.82200  1.000 31.22938  ? 440  HOH B O     1 
HETATM 4966 O O     . HOH G 4 .   ? -14.85700 45.77200  -29.68900 1.000 38.56602  ? 441  HOH B O     1 
HETATM 4967 O O     . HOH G 4 .   ? -41.37100 15.68600  -9.38200  1.000 42.75567  ? 442  HOH B O     1 
HETATM 4968 O O     . HOH G 4 .   ? -10.60900 19.48500  -13.92100 1.000 47.00055  ? 443  HOH B O     1 
HETATM 4969 O O     . HOH G 4 .   ? -10.84400 23.95700  -13.16600 1.000 44.13797  ? 444  HOH B O     1 
HETATM 4970 O O     . HOH G 4 .   ? -9.34600  49.32400  -8.33800  1.000 19.16489  ? 445  HOH B O     1 
HETATM 4971 O O     . HOH G 4 .   ? -15.73200 35.70000  -32.75200 1.000 53.26040  ? 446  HOH B O     1 
HETATM 4972 O O     . HOH G 4 .   ? -9.38900  52.03600  -8.88800  1.000 21.82589  ? 447  HOH B O     1 
HETATM 4973 O O     . HOH G 4 .   ? -31.05400 17.83300  -22.28700 1.000 59.80064  ? 448  HOH B O     1 
HETATM 4974 O O     . HOH G 4 .   ? -18.95400 22.63500  -6.27400  1.000 33.49305  ? 449  HOH B O     1 
HETATM 4975 O O     . HOH G 4 .   ? -6.373    45.243    -36.135   1.000 31.42430  ? 450  HOH B O     1 
HETATM 4976 O O     . HOH G 4 .   ? -37.33300 17.14800  3.26100   1.000 49.29749  ? 451  HOH B O     1 
HETATM 4977 O O     . HOH G 4 .   ? -20.66400 40.36200  -26.82900 1.000 48.28528  ? 452  HOH B O     1 
HETATM 4978 O O     . HOH G 4 .   ? -27.04500 32.25600  -13.88700 1.000 29.96627  ? 453  HOH B O     1 
HETATM 4979 O O     . HOH G 4 .   ? -39.99000 14.61700  -18.74000 1.000 57.45994  ? 454  HOH B O     1 
HETATM 4980 O O     . HOH G 4 .   ? 7.23100   41.04400  -10.94300 1.000 55.51805  ? 455  HOH B O     1 
HETATM 4981 O O     . HOH G 4 .   ? -24.27200 32.42400  -13.73100 1.000 31.18337  ? 456  HOH B O     1 
HETATM 4982 O O     . HOH G 4 .   ? -9.77000  53.16000  -23.66500 1.000 40.58583  ? 457  HOH B O     1 
HETATM 4983 O O     . HOH G 4 .   ? -21.70000 42.08000  -23.07800 1.000 47.84203  ? 458  HOH B O     1 
HETATM 4984 O O     . HOH G 4 .   ? -19.24600 16.88200  -11.96100 1.000 35.26688  ? 459  HOH B O     1 
HETATM 4985 O O     . HOH G 4 .   ? -20.99700 24.37200  -5.47400  1.000 33.57042  ? 460  HOH B O     1 
HETATM 4986 O O     . HOH G 4 .   ? 1.89200   47.46500  -29.12300 1.000 54.36681  ? 461  HOH B O     1 
HETATM 4987 O O     . HOH G 4 .   ? -32.39600 26.03200  -17.67400 1.000 40.33978  ? 462  HOH B O     1 
HETATM 4988 O O     . HOH G 4 .   ? -6.91400  34.54900  -6.24400  1.000 31.08201  ? 463  HOH B O     1 
HETATM 4989 O O     . HOH G 4 .   ? -12.89900 39.61000  -33.25700 1.000 43.51939  ? 464  HOH B O     1 
HETATM 4990 O O     . HOH G 4 .   ? -15.51700 19.22000  -17.04100 1.000 37.53514  ? 465  HOH B O     1 
HETATM 4991 O O     . HOH G 4 .   ? -32.66400 22.33200  2.58400   1.000 39.26002  ? 466  HOH B O     1 
HETATM 4992 O O     . HOH G 4 .   ? 5.33900   44.77000  -6.60900  1.000 49.99187  ? 467  HOH B O     1 
HETATM 4993 O O     . HOH G 4 .   ? -8.50300  23.51000  -15.85200 1.000 37.71536  ? 468  HOH B O     1 
HETATM 4994 O O     . HOH G 4 .   ? -18.89800 45.93500  -19.95100 1.000 43.72632  ? 469  HOH B O     1 
HETATM 4995 O O     . HOH G 4 .   ? 3.44500   39.03100  -14.92200 1.000 54.91569  ? 470  HOH B O     1 
HETATM 4996 O O     . HOH G 4 .   ? -33.14300 22.21700  -17.76000 1.000 41.64416  ? 471  HOH B O     1 
HETATM 4997 O O     . HOH G 4 .   ? -40.45300 15.20100  -2.56000  1.000 54.15377  ? 472  HOH B O     1 
HETATM 4998 O O     . HOH G 4 .   ? -9.00800  26.63700  -29.46000 1.000 50.46116  ? 473  HOH B O     1 
HETATM 4999 O O     . HOH G 4 .   ? -25.93100 -1.99800  -0.18300  1.000 64.43978  ? 474  HOH B O     1 
HETATM 5000 O O     . HOH G 4 .   ? -11.64700 60.82300  -11.44600 1.000 37.30865  ? 475  HOH B O     1 
HETATM 5001 O O     . HOH G 4 .   ? -6.62900  30.29900  -38.67300 1.000 49.46461  ? 476  HOH B O     1 
HETATM 5002 O O     . HOH G 4 .   ? -1.95200  30.52100  -21.93000 1.000 41.11337  ? 477  HOH B O     1 
HETATM 5003 O O     . HOH G 4 .   ? -9.24800  22.44200  -4.67800  1.000 51.68642  ? 478  HOH B O     1 
HETATM 5004 O O     . HOH G 4 .   ? -13.87500 37.09900  -6.45700  1.000 26.75280  ? 479  HOH B O     1 
HETATM 5005 O O     . HOH G 4 .   ? 6.28000   51.93400  1.00500   1.000 42.64175  ? 480  HOH B O     1 
HETATM 5006 O O     . HOH G 4 .   ? -20.75000 39.68300  -17.76900 1.000 39.65193  ? 481  HOH B O     1 
HETATM 5007 O O     . HOH G 4 .   ? -11.18100 23.21200  -22.22200 1.000 37.85175  ? 482  HOH B O     1 
HETATM 5008 O O     . HOH G 4 .   ? 6.62800   47.07000  -25.70100 1.000 52.73643  ? 483  HOH B O     1 
HETATM 5009 O O     . HOH G 4 .   ? -13.96300 28.73500  -29.42300 1.000 46.87366  ? 484  HOH B O     1 
HETATM 5010 O O     . HOH G 4 .   ? 7.15900   35.30700  -24.72800 1.000 50.12038  ? 485  HOH B O     1 
HETATM 5011 O O     . HOH G 4 .   ? -9.44500  52.03300  -25.75900 1.000 44.53996  ? 486  HOH B O     1 
HETATM 5012 O O     . HOH G 4 .   ? 0.21100   33.01300  -31.55400 1.000 47.36768  ? 487  HOH B O     1 
HETATM 5013 O O     . HOH G 4 .   ? -12.57000 17.65100  -11.22100 1.000 42.58080  ? 488  HOH B O     1 
HETATM 5014 O O     . HOH G 4 .   ? -2.57900  30.05300  -5.27200  1.000 48.48232  ? 489  HOH B O     1 
HETATM 5015 O O     . HOH G 4 .   ? -11.81600 48.52000  -30.77800 1.000 47.56566  ? 490  HOH B O     1 
HETATM 5016 O O     . HOH G 4 .   ? -20.70400 29.28500  -3.56300  1.000 42.79666  ? 491  HOH B O     1 
HETATM 5017 O O     . HOH G 4 .   ? -20.99400 39.62000  -23.27700 1.000 46.51824  ? 492  HOH B O     1 
HETATM 5018 O O     . HOH G 4 .   ? -19.90900 46.45900  -16.94000 1.000 38.01740  ? 493  HOH B O     1 
HETATM 5019 O O     . HOH G 4 .   ? 5.74700   40.87300  -29.10800 1.000 54.32271  ? 494  HOH B O     1 
HETATM 5020 O O     . HOH G 4 .   ? -13.47800 58.71100  -9.66700  1.000 33.98454  ? 495  HOH B O     1 
HETATM 5021 O O     . HOH G 4 .   ? -3.29100  40.10700  -30.01500 1.000 33.92431  ? 496  HOH B O     1 
HETATM 5022 O O     . HOH G 4 .   ? 3.81800   46.96900  -7.87900  1.000 32.86759  ? 497  HOH B O     1 
HETATM 5023 O O     . HOH G 4 .   ? -26.56400 22.44700  -20.63900 1.000 40.51758  ? 498  HOH B O     1 
HETATM 5024 O O     . HOH G 4 .   ? -6.56200  62.81400  -12.86000 1.000 33.83039  ? 499  HOH B O     1 
HETATM 5025 O O     . HOH G 4 .   ? -18.61200 19.36400  -11.54000 1.000 38.46041  ? 500  HOH B O     1 
HETATM 5026 O O     . HOH G 4 .   ? -5.50600  31.56000  -24.73200 1.000 35.61381  ? 501  HOH B O     1 
HETATM 5027 O O     . HOH G 4 .   ? -38.65900 11.25000  -7.08000  1.000 49.98571  ? 502  HOH B O     1 
HETATM 5028 O O     . HOH G 4 .   ? -18.35600 48.53000  -18.93000 1.000 41.18549  ? 503  HOH B O     1 
HETATM 5029 O O     . HOH G 4 .   ? 6.33600   39.41300  -14.29800 1.000 64.44105  ? 504  HOH B O     1 
HETATM 5030 O O     . HOH G 4 .   ? -35.63300 5.66900   -8.27300  1.000 55.94514  ? 505  HOH B O     1 
HETATM 5031 O O     . HOH G 4 .   ? -38.41900 11.51200  -11.72200 1.000 41.79373  ? 506  HOH B O     1 
HETATM 5032 O O     . HOH G 4 .   ? -34.20500 12.10200  0.28600   1.000 39.58189  ? 507  HOH B O     1 
HETATM 5033 O O     . HOH G 4 .   ? 3.37600   50.27100  4.15500   1.000 43.26201  ? 508  HOH B O     1 
HETATM 5034 O O     . HOH G 4 .   ? -16.93300 9.23000   -4.58700  1.000 58.65183  ? 509  HOH B O     1 
HETATM 5035 O O     . HOH G 4 .   ? 4.24500   51.45600  -7.38000  1.000 32.46123  ? 510  HOH B O     1 
HETATM 5036 O O     . HOH G 4 .   ? -13.48200 11.20900  -21.87800 1.000 50.99605  ? 511  HOH B O     1 
HETATM 5037 O O     . HOH G 4 .   ? -14.16100 23.94400  -19.92000 1.000 34.42278  ? 512  HOH B O     1 
HETATM 5038 O O     . HOH G 4 .   ? -40.72500 18.00200  -10.36600 1.000 43.32550  ? 513  HOH B O     1 
HETATM 5039 O O     . HOH G 4 .   ? -20.63600 21.31900  -8.24600  1.000 34.84446  ? 514  HOH B O     1 
HETATM 5040 O O     . HOH G 4 .   ? 8.15300   43.48300  8.08000   1.000 49.44390  ? 515  HOH B O     1 
HETATM 5041 O O     . HOH G 4 .   ? -1.918    28.858    -30.662   1.000 43.01321  ? 516  HOH B O     1 
HETATM 5042 O O     . HOH G 4 .   ? -14.24500 16.50800  -8.33600  1.000 51.87440  ? 517  HOH B O     1 
HETATM 5043 O O     . HOH G 4 .   ? -25.05000 24.97200  -0.45300  1.000 48.57778  ? 518  HOH B O     1 
HETATM 5044 O O     . HOH G 4 .   ? -1.28900  42.29000  -32.50200 1.000 43.61229  ? 519  HOH B O     1 
HETATM 5045 O O     . HOH G 4 .   ? -35.35200 19.91200  -17.19600 1.000 47.87354  ? 520  HOH B O     1 
HETATM 5046 O O     . HOH G 4 .   ? 4.12200   37.17900  -3.58500  1.000 55.91296  ? 521  HOH B O     1 
HETATM 5047 O O     . HOH G 4 .   ? 3.59300   53.31500  -21.32500 1.000 42.09866  ? 522  HOH B O     1 
HETATM 5048 O O     . HOH G 4 .   ? -2.10100  35.37300  -37.80100 1.000 39.68740  ? 523  HOH B O     1 
HETATM 5049 O O     . HOH G 4 .   ? 6.86700   45.45300  -2.17200  1.000 52.24333  ? 524  HOH B O     1 
HETATM 5050 O O     . HOH G 4 .   ? 5.70600   39.86200  -7.51200  1.000 50.40909  ? 525  HOH B O     1 
HETATM 5051 O O     . HOH G 4 .   ? -2.39900  47.11700  -27.69100 1.000 41.82329  ? 526  HOH B O     1 
HETATM 5052 O O     . HOH G 4 .   ? -14.64700 59.38700  -17.87100 1.000 39.24423  ? 527  HOH B O     1 
HETATM 5053 O O     . HOH G 4 .   ? -10.00900 34.00600  -33.37000 1.000 47.08537  ? 528  HOH B O     1 
HETATM 5054 O O     . HOH G 4 .   ? 0.07300   31.74800  -22.82300 1.000 51.99437  ? 529  HOH B O     1 
HETATM 5055 O O     . HOH G 4 .   ? -2.17000  27.65000  -27.27400 1.000 44.45211  ? 530  HOH B O     1 
HETATM 5056 O O     . HOH G 4 .   ? -3.89100  27.66100  -24.74900 1.000 34.03672  ? 531  HOH B O     1 
HETATM 5057 O O     . HOH G 4 .   ? 4.39400   49.55300  -25.83200 1.000 43.52763  ? 532  HOH B O     1 
HETATM 5058 O O     . HOH G 4 .   ? 4.48700   49.12100  -6.31400  1.000 40.13724  ? 533  HOH B O     1 
HETATM 5059 O O     . HOH G 4 .   ? -3.21900  53.86900  -21.80100 1.000 33.17613  ? 534  HOH B O     1 
HETATM 5060 O O     . HOH G 4 .   ? 7.24900   47.91500  -9.11200  1.000 48.28500  ? 535  HOH B O     1 
HETATM 5061 O O     . HOH G 4 .   ? -5.58400  31.80200  -3.11500  1.000 41.57753  ? 536  HOH B O     1 
HETATM 5062 O O     . HOH G 4 .   ? -8.10200  20.00300  -8.33600  1.000 54.72285  ? 537  HOH B O     1 
HETATM 5063 O O     . HOH G 4 .   ? 5.06400   53.86600  0.00800   1.000 35.65489  ? 538  HOH B O     1 
HETATM 5064 O O     . HOH G 4 .   ? -32.13500 11.51100  -16.44200 1.000 50.95569  ? 539  HOH B O     1 
HETATM 5065 O O     . HOH G 4 .   ? -20.11900 43.37000  -25.38900 1.000 54.92559  ? 540  HOH B O     1 
HETATM 5066 O O     . HOH G 4 .   ? -26.89400 27.35900  -1.64700  1.000 37.81442  ? 541  HOH B O     1 
HETATM 5067 O O     . HOH G 4 .   ? -26.47700 8.81800   -13.41900 1.000 50.30734  ? 542  HOH B O     1 
HETATM 5068 O O     . HOH G 4 .   ? -11.03400 36.01400  -34.63900 1.000 45.55484  ? 543  HOH B O     1 
HETATM 5069 O O     . HOH G 4 .   ? -26.52700 32.41600  -20.01600 1.000 43.30580  ? 544  HOH B O     1 
HETATM 5070 O O     . HOH G 4 .   ? -10.70600 19.84100  -10.26800 1.000 53.12103  ? 545  HOH B O     1 
HETATM 5071 O O     . HOH G 4 .   ? -25.24200 14.25000  -21.86800 1.000 58.07032  ? 546  HOH B O     1 
HETATM 5072 O O     . HOH G 4 .   ? -21.10300 29.39000  -30.07000 1.000 60.26577  ? 547  HOH B O     1 
HETATM 5073 O O     . HOH G 4 .   ? -10.11900 12.73000  -14.96400 1.000 48.83325  ? 548  HOH B O     1 
HETATM 5074 O O     . HOH G 4 .   ? -30.813   1.776     -2.556    1.000 35.56401  ? 549  HOH B O     1 
HETATM 5075 O O     . HOH G 4 .   ? -8.86700  31.66300  -38.64300 1.000 58.13653  ? 550  HOH B O     1 
HETATM 5076 O O     . HOH G 4 .   ? -38.05600 9.36100   -10.54500 1.000 52.21609  ? 551  HOH B O     1 
HETATM 5077 O O     . HOH G 4 .   ? 7.50300   33.64300  -15.15300 1.000 67.91114  ? 552  HOH B O     1 
HETATM 5078 O O     . HOH G 4 .   ? -6.52700  32.95300  -22.82300 1.000 35.10473  ? 553  HOH B O     1 
HETATM 5079 O O     . HOH G 4 .   ? -0.58800  55.56600  -19.20600 1.000 47.71959  ? 554  HOH B O     1 
HETATM 5080 O O     . HOH G 4 .   ? -29.493   32.714    -6.821    1.000 44.17018  ? 555  HOH B O     1 
HETATM 5081 O O     . HOH G 4 .   ? -39.61700 0.92700   -4.92400  1.000 46.16907  ? 556  HOH B O     1 
HETATM 5082 O O     . HOH G 4 .   ? 6.76500   44.82700  -17.57000 1.000 49.48858  ? 557  HOH B O     1 
HETATM 5083 O O     . HOH G 4 .   ? -18.66800 16.30400  -6.71200  1.000 45.33417  ? 558  HOH B O     1 
HETATM 5084 O O     . HOH G 4 .   ? -41.10400 19.23800  -12.99900 1.000 47.84707  ? 559  HOH B O     1 
HETATM 5085 O O     . HOH G 4 .   ? -30.84500 9.54900   5.37400   1.000 43.34373  ? 560  HOH B O     1 
HETATM 5086 O O     . HOH G 4 .   ? -12.07000 59.12500  -23.30000 1.000 47.61366  ? 561  HOH B O     1 
HETATM 5087 O O     . HOH G 4 .   ? -14.65300 20.90700  -19.65000 1.000 53.23681  ? 562  HOH B O     1 
HETATM 5088 O O     . HOH G 4 .   ? -20.69300 36.17700  -25.75800 1.000 44.52895  ? 563  HOH B O     1 
HETATM 5089 O O     . HOH G 4 .   ? -34.642   30.927    -1.671    1.000 27.76020  ? 564  HOH B O     1 
HETATM 5090 O O     . HOH G 4 .   ? -6.67300  29.65200  -16.10700 1.000 42.47574  ? 565  HOH B O     1 
HETATM 5091 O O     . HOH G 4 .   ? -35.57700 4.07700   5.69300   1.000 60.27993  ? 566  HOH B O     1 
HETATM 5092 O O     . HOH G 4 .   ? -28.33900 22.83500  -0.76500  1.000 26.91189  ? 567  HOH B O     1 
HETATM 5093 O O     . HOH G 4 .   ? -22.09600 27.82200  -22.42900 1.000 58.26008  ? 568  HOH B O     1 
HETATM 5094 O O     . HOH G 4 .   ? -33.300   29.403    -18.964   1.000 48.81355  ? 569  HOH B O     1 
HETATM 5095 O O     . HOH G 4 .   ? -5.86300  49.89800  -30.18500 1.000 48.03898  ? 570  HOH B O     1 
HETATM 5096 O O     . HOH G 4 .   ? -6.641    52.670    -35.300   1.000 53.50269  ? 571  HOH B O     1 
HETATM 5097 O O     . HOH G 4 .   ? 8.410     52.550    -14.191   1.000 39.15951  ? 572  HOH B O     1 
HETATM 5098 O O     . HOH G 4 .   ? -4.25700  36.68600  -38.80800 1.000 46.13214  ? 573  HOH B O     1 
HETATM 5099 O O     . HOH G 4 .   ? 12.048    43.612    8.841     1.000 47.12776  ? 574  HOH B O     1 
HETATM 5100 O O     . HOH G 4 .   ? -28.21100 34.02700  -15.81300 1.000 37.48241  ? 575  HOH B O     1 
HETATM 5101 O O     . HOH G 4 .   ? -42.041   17.508    -2.762    1.000 47.80832  ? 576  HOH B O     1 
HETATM 5102 O O     . HOH G 4 .   ? -10.85700 56.54300  -25.06900 1.000 48.82326  ? 577  HOH B O     1 
HETATM 5103 O O     . HOH G 4 .   ? 0.35600   30.41000  -30.75200 1.000 45.57616  ? 578  HOH B O     1 
HETATM 5104 O O     . HOH G 4 .   ? -15.85100 24.90200  -22.34900 1.000 40.21917  ? 579  HOH B O     1 
HETATM 5105 O O     . HOH G 4 .   ? 5.89800   37.41800  -5.58700  1.000 58.96438  ? 580  HOH B O     1 
HETATM 5106 O O     . HOH G 4 .   ? -36.153   23.752    -15.598   1.000 55.04763  ? 581  HOH B O     1 
HETATM 5107 O O     . HOH G 4 .   ? -28.92800 34.10600  -3.94400  1.000 52.11793  ? 582  HOH B O     1 
HETATM 5108 O O     . HOH G 4 .   ? -3.47200  30.59600  -24.11700 1.000 41.92608  ? 583  HOH B O     1 
HETATM 5109 O O     . HOH G 4 .   ? -9.25000  63.50800  -17.97200 1.000 45.92121  ? 584  HOH B O     1 
HETATM 5110 O O     . HOH G 4 .   ? 4.77000   55.37700  -20.28300 1.000 45.02134  ? 585  HOH B O     1 
HETATM 5111 O O     . HOH G 4 .   ? -19.34800 59.11100  -18.76900 1.000 50.99648  ? 586  HOH B O     1 
HETATM 5112 O O     . HOH G 4 .   ? 1.71200   29.07100  -12.87500 1.000 64.10128  ? 587  HOH B O     1 
HETATM 5113 O O     . HOH G 4 .   ? -30.69500 35.40900  -13.81200 1.000 53.18350  ? 588  HOH B O     1 
HETATM 5114 O O     . HOH G 4 .   ? -21.21100 8.94900   5.03200   1.000 55.16557  ? 589  HOH B O     1 
HETATM 5115 O O     . HOH G 4 .   ? -27.84000 34.32000  -18.63400 1.000 50.09380  ? 590  HOH B O     1 
HETATM 5116 O O     . HOH G 4 .   ? -3.07500  42.80000  -30.40000 1.000 36.54024  ? 591  HOH B O     1 
HETATM 5117 O O     . HOH G 4 .   ? -22.60300 39.23300  -20.07300 1.000 53.29894  ? 592  HOH B O     1 
HETATM 5118 O O     . HOH G 4 .   ? -5.97000  23.40700  -6.51500  1.000 43.84828  ? 593  HOH B O     1 
HETATM 5119 O O     . HOH G 4 .   ? -26.63500 36.87300  -18.87200 1.000 53.09681  ? 594  HOH B O     1 
HETATM 5120 O O     . HOH G 4 .   ? 9.653     52.454    -16.256   1.000 44.40292  ? 595  HOH B O     1 
HETATM 5121 O O     . HOH G 4 .   ? -9.01200  17.27100  -14.58200 1.000 52.05012  ? 596  HOH B O     1 
HETATM 5122 O O     . HOH G 4 .   ? -19.328   12.000    -27.635   1.000 80.47814  ? 597  HOH B O     1 
HETATM 5123 O O     . HOH G 4 .   ? 19.18400  28.07600  -21.02200 1.000 70.57941  ? 598  HOH B O     1 
HETATM 5124 O O     . HOH H 4 .   ? -20.67500 -6.49700  17.06200  1.000 94.15104  ? 2601 HOH C O     1 
HETATM 5125 O O     . HOH H 4 .   ? -25.15900 32.50500  2.81900   1.000 46.12964  ? 2602 HOH C O     1 
HETATM 5126 O O     . HOH H 4 .   ? -8.55300  13.58200  2.66800   1.000 62.14323  ? 2603 HOH C O     1 
HETATM 5127 O O     . HOH H 4 .   ? -6.81700  21.32200  3.84700   1.000 60.85728  ? 2604 HOH C O     1 
HETATM 5128 O O     . HOH H 4 .   ? -7.54300  26.83600  10.25500  1.000 39.28873  ? 2605 HOH C O     1 
HETATM 5129 O O     . HOH H 4 .   ? -9.36300  -2.58800  9.43100   1.000 107.53917 ? 2606 HOH C O     1 
HETATM 5130 O O     . HOH H 4 .   ? -8.60100  23.80400  8.51900   1.000 54.11298  ? 2607 HOH C O     1 
HETATM 5131 O O     . HOH H 4 .   ? -11.78200 6.66500   29.48700  1.000 110.84127 ? 2608 HOH C O     1 
HETATM 5132 O O     . HOH H 4 .   ? -10.57900 26.96500  13.20100  1.000 46.25632  ? 2609 HOH C O     1 
HETATM 5133 O O     . HOH H 4 .   ? -29.42400 24.76600  6.65900   1.000 60.54106  ? 2610 HOH C O     1 
HETATM 5134 O O     . HOH H 4 .   ? -31.15200 -6.43900  9.65700   1.000 57.02687  ? 2611 HOH C O     1 
HETATM 5135 O O     . HOH H 4 .   ? -8.66000  36.11000  -3.21000  1.000 33.70018  ? 2612 HOH C O     1 
HETATM 5136 O O     . HOH H 4 .   ? -9.83900  8.91600   16.00200  1.000 110.89119 ? 2613 HOH C O     1 
HETATM 5137 O O     . HOH H 4 .   ? -7.71200  23.80000  1.97300   1.000 55.22867  ? 2614 HOH C O     1 
HETATM 5138 O O     . HOH H 4 .   ? -16.44500 8.47000   14.72500  1.000 114.46575 ? 2615 HOH C O     1 
HETATM 5139 O O     . HOH H 4 .   ? -21.46300 1.95700   7.68100   1.000 72.62335  ? 2616 HOH C O     1 
HETATM 5140 O O     . HOH H 4 .   ? -15.22200 4.89600   19.04400  1.000 111.11997 ? 2617 HOH C O     1 
HETATM 5141 O O     . HOH H 4 .   ? -10.77500 27.97700  -0.45600  1.000 32.40507  ? 2618 HOH C O     1 
HETATM 5142 O O     . HOH H 4 .   ? -22.16900 26.68500  16.60900  1.000 57.14253  ? 2619 HOH C O     1 
HETATM 5143 O O     . HOH H 4 .   ? -26.48400 -7.38500  -1.15000  1.000 57.38899  ? 2620 HOH C O     1 
HETATM 5144 O O     . HOH H 4 .   ? -28.81000 -8.32700  12.89800  1.000 79.88206  ? 2621 HOH C O     1 
HETATM 5145 O O     . HOH H 4 .   ? -16.09000 28.47300  6.32200   1.000 30.26673  ? 2622 HOH C O     1 
HETATM 5146 O O     . HOH H 4 .   ? -15.75000 33.74400  -4.34500  1.000 25.70400  ? 2623 HOH C O     1 
HETATM 5147 O O     . HOH H 4 .   ? -7.64800  25.41400  -6.29600  1.000 33.93686  ? 2624 HOH C O     1 
HETATM 5148 O O     . HOH H 4 .   ? -18.86200 6.56700   25.61500  1.000 119.64305 ? 2625 HOH C O     1 
HETATM 5149 O O     . HOH H 4 .   ? -32.079   -1.755    5.162     1.000 42.32308  ? 2626 HOH C O     1 
HETATM 5150 O O     . HOH H 4 .   ? -28.34800 7.63600   5.54900   1.000 46.04824  ? 2627 HOH C O     1 
HETATM 5151 O O     . HOH H 4 .   ? -16.52600 3.74300   35.75500  1.000 81.30381  ? 2628 HOH C O     1 
HETATM 5152 O O     . HOH H 4 .   ? -30.27700 -0.14500  1.78900   1.000 51.71881  ? 2629 HOH C O     1 
HETATM 5153 O O     . HOH H 4 .   ? -14.11600 31.75700  15.05900  1.000 50.91910  ? 2630 HOH C O     1 
HETATM 5154 O O     . HOH H 4 .   ? -20.79000 28.28200  9.87300   1.000 44.23719  ? 2631 HOH C O     1 
HETATM 5155 O O     . HOH H 4 .   ? -28.10000 1.52500   11.09700  1.000 66.59335  ? 2632 HOH C O     1 
HETATM 5156 O O     . HOH H 4 .   ? -25.81000 -5.14900  15.74200  1.000 87.53295  ? 2633 HOH C O     1 
HETATM 5157 O O     . HOH H 4 .   ? -27.20500 -0.67900  10.25600  1.000 74.21335  ? 2634 HOH C O     1 
HETATM 5158 O O     . HOH H 4 .   ? -15.97300 10.79200  13.56900  1.000 111.59577 ? 2635 HOH C O     1 
HETATM 5159 O O     . HOH H 4 .   ? -18.08500 -8.68500  18.62600  1.000 91.06335  ? 2636 HOH C O     1 
HETATM 5160 O O     . HOH H 4 .   ? -22.74100 35.71700  -5.73100  1.000 31.00741  ? 2637 HOH C O     1 
HETATM 5161 O O     . HOH H 4 .   ? -24.80200 15.32200  19.87300  1.000 77.99156  ? 2638 HOH C O     1 
HETATM 5162 O O     . HOH H 4 .   ? -9.18200  -3.46400  24.56500  1.000 92.26161  ? 2639 HOH C O     1 
HETATM 5163 O O     . HOH H 4 .   ? -14.72500 20.74100  9.58700   1.000 50.61612  ? 2640 HOH C O     1 
HETATM 5164 O O     . HOH H 4 .   ? -16.96300 36.55200  1.00900   1.000 24.14753  ? 2641 HOH C O     1 
HETATM 5165 O O     . HOH H 4 .   ? -12.45500 28.11000  3.11700   1.000 33.85940  ? 2642 HOH C O     1 
HETATM 5166 O O     . HOH H 4 .   ? -12.05800 17.57900  0.09400   1.000 54.83964  ? 2643 HOH C O     1 
HETATM 5167 O O     . HOH H 4 .   ? -19.63900 31.35600  6.30000   1.000 32.28661  ? 2644 HOH C O     1 
HETATM 5168 O O     . HOH H 4 .   ? -24.01900 28.35700  -1.38300  1.000 45.42068  ? 2645 HOH C O     1 
HETATM 5169 O O     . HOH H 4 .   ? -12.34000 22.47800  8.87300   1.000 43.32658  ? 2646 HOH C O     1 
HETATM 5170 O O     . HOH H 4 .   ? -22.63900 27.29500  13.45300  1.000 57.82711  ? 2647 HOH C O     1 
HETATM 5171 O O     . HOH H 4 .   ? -21.17300 -8.13300  7.64800   1.000 87.98368  ? 2648 HOH C O     1 
HETATM 5172 O O     . HOH H 4 .   ? -21.67500 17.85500  10.46100  1.000 53.45334  ? 2649 HOH C O     1 
HETATM 5173 O O     . HOH H 4 .   ? -23.32000 -2.70700  12.75900  1.000 87.55378  ? 2650 HOH C O     1 
HETATM 5174 O O     . HOH H 4 .   ? -6.72400  27.99400  -5.77300  1.000 37.04352  ? 2651 HOH C O     1 
HETATM 5175 O O     . HOH H 4 .   ? -18.65000 29.17300  0.90600   1.000 39.04277  ? 2652 HOH C O     1 
HETATM 5176 O O     . HOH H 4 .   ? -11.71100 -8.43300  15.00500  1.000 75.41006  ? 2653 HOH C O     1 
HETATM 5177 O O     . HOH H 4 .   ? -24.26800 20.61500  8.25500   1.000 50.77132  ? 2654 HOH C O     1 
HETATM 5178 O O     . HOH H 4 .   ? -8.70900  16.84400  -2.12600  1.000 67.46082  ? 2655 HOH C O     1 
HETATM 5179 O O     . HOH H 4 .   ? -22.16300 26.44800  1.72600   1.000 35.34526  ? 2656 HOH C O     1 
HETATM 5180 O O     . HOH H 4 .   ? -26.06400 30.32900  8.90300   1.000 59.05500  ? 2657 HOH C O     1 
HETATM 5181 O O     . HOH H 4 .   ? -7.03600  18.13600  5.31200   1.000 56.65480  ? 2658 HOH C O     1 
HETATM 5182 O O     . HOH H 4 .   ? -28.66800 12.58700  14.49000  1.000 78.98807  ? 2659 HOH C O     1 
HETATM 5183 O O     . HOH H 4 .   ? -18.18200 -5.83600  18.00300  1.000 97.95308  ? 2660 HOH C O     1 
HETATM 5184 O O     . HOH H 4 .   ? -22.81700 -0.14700  20.16500  1.000 113.47650 ? 2661 HOH C O     1 
HETATM 5185 O O     . HOH H 4 .   ? -11.52100 9.88600   10.55700  1.000 112.18529 ? 2662 HOH C O     1 
HETATM 5186 O O     . HOH H 4 .   ? -14.78500 7.98500   19.85700  1.000 86.10651  ? 2663 HOH C O     1 
HETATM 5187 O O     . HOH H 4 .   ? -10.38500 26.35200  2.22500   1.000 40.95958  ? 2664 HOH C O     1 
HETATM 5188 O O     . HOH H 4 .   ? -25.88700 28.13800  1.84400   1.000 50.67367  ? 2665 HOH C O     1 
HETATM 5189 O O     . HOH H 4 .   ? -33.03700 -3.72100  24.55600  1.000 125.72543 ? 2666 HOH C O     1 
HETATM 5190 O O     . HOH H 4 .   ? -14.46300 21.15000  12.87500  1.000 55.12141  ? 2667 HOH C O     1 
HETATM 5191 O O     . HOH H 4 .   ? -13.34300 24.29200  12.75800  1.000 49.04974  ? 2668 HOH C O     1 
HETATM 5192 O O     . HOH H 4 .   ? -25.37500 23.52900  6.26300   1.000 54.43296  ? 2669 HOH C O     1 
HETATM 5193 O O     . HOH H 4 .   ? -5.64100  24.36800  -1.95300  1.000 58.99734  ? 2670 HOH C O     1 
HETATM 5194 O O     . HOH H 4 .   ? -15.87500 16.35100  -6.28000  1.000 52.78650  ? 2671 HOH C O     1 
HETATM 5195 O O     . HOH H 4 .   ? -10.27900 32.59800  0.34900   1.000 40.36749  ? 2672 HOH C O     1 
HETATM 5196 O O     . HOH H 4 .   ? -15.53700 32.11300  12.69000  1.000 38.98099  ? 2673 HOH C O     1 
HETATM 5197 O O     . HOH H 4 .   ? -13.77600 35.32700  -4.69100  1.000 30.27500  ? 2674 HOH C O     1 
HETATM 5198 O O     . HOH H 4 .   ? -25.85200 22.03400  16.63200  1.000 66.01411  ? 2675 HOH C O     1 
HETATM 5199 O O     . HOH H 4 .   ? -22.20400 22.48800  24.32100  1.000 90.03335  ? 2676 HOH C O     1 
HETATM 5200 O O     . HOH H 4 .   ? -19.41600 1.82700   5.10900   1.000 72.62335  ? 2677 HOH C O     1 
HETATM 5201 O O     . HOH H 4 .   ? -24.76600 25.44300  2.65000   1.000 43.83869  ? 2678 HOH C O     1 
HETATM 5202 O O     . HOH H 4 .   ? -17.80400 18.24500  10.99700  1.000 50.46555  ? 2679 HOH C O     1 
HETATM 5203 O O     . HOH H 4 .   ? -31.90400 -5.66300  14.12800  1.000 64.52069  ? 2680 HOH C O     1 
HETATM 5204 O O     . HOH H 4 .   ? -7.15900  20.49100  -4.40500  1.000 61.28391  ? 2681 HOH C O     1 
HETATM 5205 O O     . HOH H 4 .   ? -8.09600  29.84200  -0.12100  1.000 46.25502  ? 2682 HOH C O     1 
HETATM 5206 O O     . HOH H 4 .   ? -16.29100 31.93700  17.18500  1.000 58.59167  ? 2683 HOH C O     1 
HETATM 5207 O O     . HOH H 4 .   ? -21.03300 13.02300  29.35800  1.000 89.50154  ? 2684 HOH C O     1 
HETATM 5208 O O     . HOH H 4 .   ? -28.98500 8.80100   25.81900  1.000 76.26277  ? 2685 HOH C O     1 
HETATM 5209 O O     . HOH H 4 .   ? -9.44000  9.83200   -0.05800  1.000 61.05670  ? 2686 HOH C O     1 
# 
