data_9GWW
# 
_entry.id   9GWW 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9GWW         pdb_00009gww 10.2210/pdb9gww/pdb 
WWPDB D_1292142080 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-02-12 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9GWW 
_pdbx_database_status.recvd_initial_deposition_date   2024-09-27 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              gideon.davies@york.ac.uk 
_pdbx_contact_author.name_first         Gideon 
_pdbx_contact_author.name_last          'Davies J' 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-7343-776X 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Sharma, M.'   1 0000-0003-3960-2212 
'Davies, G.J.' 2 0000-0002-7343-776X 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Biochem.J. 
_citation.journal_id_ASTM           BIJOAK 
_citation.journal_id_CSD            0043 
_citation.journal_id_ISSN           1470-8728 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            482 
_citation.language                  ? 
_citation.page_first                57 
_citation.page_last                 72 
_citation.title                     
;Structure, kinetics, and mechanism of Pseudomonas putida sulfoquinovose dehydrogenase, the first enzyme in the sulfoglycolytic Entner-Doudoroff pathway.
;
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1042/BCJ20240605 
_citation.pdbx_database_id_PubMed   39840830 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Burchill, L.'         1 ?                   
primary 'Sharma, M.'           2 ?                   
primary 'Soler, N.M.'          3 ?                   
primary 'Goddard-Borger, E.D.' 4 ?                   
primary 'Davies, G.J.'         5 ?                   
primary 'Williams, S.J.'       6 0000-0001-6341-4364 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Sulfoquinovose 1-dehydrogenase'     29323.127 2   1.1.1.390 ? ? ? 
2 non-polymer syn 6-deoxy-6-sulfo-beta-D-glucopyranose 244.220   1   ?         ? ? ? 
3 water       nat water                                18.015    129 ?         ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'SQ dehydrogenase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MGSSHHHHHHSSGMNRHTDTHYPSLADKVVLISGGASGIGRAFVEAFVAQGSRVAFLDLDAEAGQGLAHALGANSLFLPC
DVRDIERLKACVAEVERTWGAVDVLINNAARDDRHALADVSVEYWDERMQTNLRHAFFAAQAVAPGMARRGSGAIINMGS
ISWMRGRPGMVCYTTAKAALNGMTRTLARELGGQGIRINSLVPGAIRTERQDAMWAADPAGLEAASQAFIDQQMLKFRLD
ASDCARLALFLASDDSRGCTGQNFVVDAGLSIQ
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MGSSHHHHHHSSGMNRHTDTHYPSLADKVVLISGGASGIGRAFVEAFVAQGSRVAFLDLDAEAGQGLAHALGANSLFLPC
DVRDIERLKACVAEVERTWGAVDVLINNAARDDRHALADVSVEYWDERMQTNLRHAFFAAQAVAPGMARRGSGAIINMGS
ISWMRGRPGMVCYTTAKAALNGMTRTLARELGGQGIRINSLVPGAIRTERQDAMWAADPAGLEAASQAFIDQQMLKFRLD
ASDCARLALFLASDDSRGCTGQNFVVDAGLSIQ
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 6-deoxy-6-sulfo-beta-D-glucopyranose YZT 
3 water                                HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   GLY n 
1 3   SER n 
1 4   SER n 
1 5   HIS n 
1 6   HIS n 
1 7   HIS n 
1 8   HIS n 
1 9   HIS n 
1 10  HIS n 
1 11  SER n 
1 12  SER n 
1 13  GLY n 
1 14  MET n 
1 15  ASN n 
1 16  ARG n 
1 17  HIS n 
1 18  THR n 
1 19  ASP n 
1 20  THR n 
1 21  HIS n 
1 22  TYR n 
1 23  PRO n 
1 24  SER n 
1 25  LEU n 
1 26  ALA n 
1 27  ASP n 
1 28  LYS n 
1 29  VAL n 
1 30  VAL n 
1 31  LEU n 
1 32  ILE n 
1 33  SER n 
1 34  GLY n 
1 35  GLY n 
1 36  ALA n 
1 37  SER n 
1 38  GLY n 
1 39  ILE n 
1 40  GLY n 
1 41  ARG n 
1 42  ALA n 
1 43  PHE n 
1 44  VAL n 
1 45  GLU n 
1 46  ALA n 
1 47  PHE n 
1 48  VAL n 
1 49  ALA n 
1 50  GLN n 
1 51  GLY n 
1 52  SER n 
1 53  ARG n 
1 54  VAL n 
1 55  ALA n 
1 56  PHE n 
1 57  LEU n 
1 58  ASP n 
1 59  LEU n 
1 60  ASP n 
1 61  ALA n 
1 62  GLU n 
1 63  ALA n 
1 64  GLY n 
1 65  GLN n 
1 66  GLY n 
1 67  LEU n 
1 68  ALA n 
1 69  HIS n 
1 70  ALA n 
1 71  LEU n 
1 72  GLY n 
1 73  ALA n 
1 74  ASN n 
1 75  SER n 
1 76  LEU n 
1 77  PHE n 
1 78  LEU n 
1 79  PRO n 
1 80  CYS n 
1 81  ASP n 
1 82  VAL n 
1 83  ARG n 
1 84  ASP n 
1 85  ILE n 
1 86  GLU n 
1 87  ARG n 
1 88  LEU n 
1 89  LYS n 
1 90  ALA n 
1 91  CYS n 
1 92  VAL n 
1 93  ALA n 
1 94  GLU n 
1 95  VAL n 
1 96  GLU n 
1 97  ARG n 
1 98  THR n 
1 99  TRP n 
1 100 GLY n 
1 101 ALA n 
1 102 VAL n 
1 103 ASP n 
1 104 VAL n 
1 105 LEU n 
1 106 ILE n 
1 107 ASN n 
1 108 ASN n 
1 109 ALA n 
1 110 ALA n 
1 111 ARG n 
1 112 ASP n 
1 113 ASP n 
1 114 ARG n 
1 115 HIS n 
1 116 ALA n 
1 117 LEU n 
1 118 ALA n 
1 119 ASP n 
1 120 VAL n 
1 121 SER n 
1 122 VAL n 
1 123 GLU n 
1 124 TYR n 
1 125 TRP n 
1 126 ASP n 
1 127 GLU n 
1 128 ARG n 
1 129 MET n 
1 130 GLN n 
1 131 THR n 
1 132 ASN n 
1 133 LEU n 
1 134 ARG n 
1 135 HIS n 
1 136 ALA n 
1 137 PHE n 
1 138 PHE n 
1 139 ALA n 
1 140 ALA n 
1 141 GLN n 
1 142 ALA n 
1 143 VAL n 
1 144 ALA n 
1 145 PRO n 
1 146 GLY n 
1 147 MET n 
1 148 ALA n 
1 149 ARG n 
1 150 ARG n 
1 151 GLY n 
1 152 SER n 
1 153 GLY n 
1 154 ALA n 
1 155 ILE n 
1 156 ILE n 
1 157 ASN n 
1 158 MET n 
1 159 GLY n 
1 160 SER n 
1 161 ILE n 
1 162 SER n 
1 163 TRP n 
1 164 MET n 
1 165 ARG n 
1 166 GLY n 
1 167 ARG n 
1 168 PRO n 
1 169 GLY n 
1 170 MET n 
1 171 VAL n 
1 172 CYS n 
1 173 TYR n 
1 174 THR n 
1 175 THR n 
1 176 ALA n 
1 177 LYS n 
1 178 ALA n 
1 179 ALA n 
1 180 LEU n 
1 181 ASN n 
1 182 GLY n 
1 183 MET n 
1 184 THR n 
1 185 ARG n 
1 186 THR n 
1 187 LEU n 
1 188 ALA n 
1 189 ARG n 
1 190 GLU n 
1 191 LEU n 
1 192 GLY n 
1 193 GLY n 
1 194 GLN n 
1 195 GLY n 
1 196 ILE n 
1 197 ARG n 
1 198 ILE n 
1 199 ASN n 
1 200 SER n 
1 201 LEU n 
1 202 VAL n 
1 203 PRO n 
1 204 GLY n 
1 205 ALA n 
1 206 ILE n 
1 207 ARG n 
1 208 THR n 
1 209 GLU n 
1 210 ARG n 
1 211 GLN n 
1 212 ASP n 
1 213 ALA n 
1 214 MET n 
1 215 TRP n 
1 216 ALA n 
1 217 ALA n 
1 218 ASP n 
1 219 PRO n 
1 220 ALA n 
1 221 GLY n 
1 222 LEU n 
1 223 GLU n 
1 224 ALA n 
1 225 ALA n 
1 226 SER n 
1 227 GLN n 
1 228 ALA n 
1 229 PHE n 
1 230 ILE n 
1 231 ASP n 
1 232 GLN n 
1 233 GLN n 
1 234 MET n 
1 235 LEU n 
1 236 LYS n 
1 237 PHE n 
1 238 ARG n 
1 239 LEU n 
1 240 ASP n 
1 241 ALA n 
1 242 SER n 
1 243 ASP n 
1 244 CYS n 
1 245 ALA n 
1 246 ARG n 
1 247 LEU n 
1 248 ALA n 
1 249 LEU n 
1 250 PHE n 
1 251 LEU n 
1 252 ALA n 
1 253 SER n 
1 254 ASP n 
1 255 ASP n 
1 256 SER n 
1 257 ARG n 
1 258 GLY n 
1 259 CYS n 
1 260 THR n 
1 261 GLY n 
1 262 GLN n 
1 263 ASN n 
1 264 PHE n 
1 265 VAL n 
1 266 VAL n 
1 267 ASP n 
1 268 ALA n 
1 269 GLY n 
1 270 LEU n 
1 271 SER n 
1 272 ILE n 
1 273 GLN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   273 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 PpSQ1_00405 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Pseudomonas putida' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     303 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          PLASMID 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       pET28a 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                              ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE                             ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE                           ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                      ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE                             ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE                            ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                      ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                              ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE                            ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                                ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE                           ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE                              ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                               ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE                           ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE                        ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE                              ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                               ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE                            ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                           ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE                             ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE                               ? 'C5 H11 N O2'    117.146 
YZT saccharide          . 6-deoxy-6-sulfo-beta-D-glucopyranose ? 'C6 H12 O8 S'    244.220 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   -12 ?   ?   ?   A . n 
A 1 2   GLY 2   -11 ?   ?   ?   A . n 
A 1 3   SER 3   -10 ?   ?   ?   A . n 
A 1 4   SER 4   -9  ?   ?   ?   A . n 
A 1 5   HIS 5   -8  ?   ?   ?   A . n 
A 1 6   HIS 6   -7  ?   ?   ?   A . n 
A 1 7   HIS 7   -6  ?   ?   ?   A . n 
A 1 8   HIS 8   -5  ?   ?   ?   A . n 
A 1 9   HIS 9   -4  ?   ?   ?   A . n 
A 1 10  HIS 10  -3  ?   ?   ?   A . n 
A 1 11  SER 11  -2  -2  SER SER A . n 
A 1 12  SER 12  -1  -1  SER SER A . n 
A 1 13  GLY 13  0   0   GLY GLY A . n 
A 1 14  MET 14  1   1   MET MET A . n 
A 1 15  ASN 15  2   2   ASN ASN A . n 
A 1 16  ARG 16  3   3   ARG ARG A . n 
A 1 17  HIS 17  4   4   HIS HIS A . n 
A 1 18  THR 18  5   5   THR THR A . n 
A 1 19  ASP 19  6   6   ASP ASP A . n 
A 1 20  THR 20  7   7   THR THR A . n 
A 1 21  HIS 21  8   8   HIS HIS A . n 
A 1 22  TYR 22  9   9   TYR TYR A . n 
A 1 23  PRO 23  10  10  PRO PRO A . n 
A 1 24  SER 24  11  11  SER SER A . n 
A 1 25  LEU 25  12  12  LEU LEU A . n 
A 1 26  ALA 26  13  13  ALA ALA A . n 
A 1 27  ASP 27  14  14  ASP ASP A . n 
A 1 28  LYS 28  15  15  LYS LYS A . n 
A 1 29  VAL 29  16  16  VAL VAL A . n 
A 1 30  VAL 30  17  17  VAL VAL A . n 
A 1 31  LEU 31  18  18  LEU LEU A . n 
A 1 32  ILE 32  19  19  ILE ILE A . n 
A 1 33  SER 33  20  20  SER SER A . n 
A 1 34  GLY 34  21  21  GLY GLY A . n 
A 1 35  GLY 35  22  22  GLY GLY A . n 
A 1 36  ALA 36  23  23  ALA ALA A . n 
A 1 37  SER 37  24  24  SER SER A . n 
A 1 38  GLY 38  25  25  GLY GLY A . n 
A 1 39  ILE 39  26  26  ILE ILE A . n 
A 1 40  GLY 40  27  27  GLY GLY A . n 
A 1 41  ARG 41  28  28  ARG ARG A . n 
A 1 42  ALA 42  29  29  ALA ALA A . n 
A 1 43  PHE 43  30  30  PHE PHE A . n 
A 1 44  VAL 44  31  31  VAL VAL A . n 
A 1 45  GLU 45  32  32  GLU GLU A . n 
A 1 46  ALA 46  33  33  ALA ALA A . n 
A 1 47  PHE 47  34  34  PHE PHE A . n 
A 1 48  VAL 48  35  35  VAL VAL A . n 
A 1 49  ALA 49  36  36  ALA ALA A . n 
A 1 50  GLN 50  37  37  GLN GLN A . n 
A 1 51  GLY 51  38  38  GLY GLY A . n 
A 1 52  SER 52  39  39  SER SER A . n 
A 1 53  ARG 53  40  40  ARG ARG A . n 
A 1 54  VAL 54  41  41  VAL VAL A . n 
A 1 55  ALA 55  42  42  ALA ALA A . n 
A 1 56  PHE 56  43  43  PHE PHE A . n 
A 1 57  LEU 57  44  44  LEU LEU A . n 
A 1 58  ASP 58  45  45  ASP ASP A . n 
A 1 59  LEU 59  46  46  LEU LEU A . n 
A 1 60  ASP 60  47  47  ASP ASP A . n 
A 1 61  ALA 61  48  48  ALA ALA A . n 
A 1 62  GLU 62  49  49  GLU GLU A . n 
A 1 63  ALA 63  50  50  ALA ALA A . n 
A 1 64  GLY 64  51  51  GLY GLY A . n 
A 1 65  GLN 65  52  52  GLN GLN A . n 
A 1 66  GLY 66  53  53  GLY GLY A . n 
A 1 67  LEU 67  54  54  LEU LEU A . n 
A 1 68  ALA 68  55  55  ALA ALA A . n 
A 1 69  HIS 69  56  56  HIS HIS A . n 
A 1 70  ALA 70  57  57  ALA ALA A . n 
A 1 71  LEU 71  58  58  LEU LEU A . n 
A 1 72  GLY 72  59  59  GLY GLY A . n 
A 1 73  ALA 73  60  60  ALA ALA A . n 
A 1 74  ASN 74  61  61  ASN ASN A . n 
A 1 75  SER 75  62  62  SER SER A . n 
A 1 76  LEU 76  63  63  LEU LEU A . n 
A 1 77  PHE 77  64  64  PHE PHE A . n 
A 1 78  LEU 78  65  65  LEU LEU A . n 
A 1 79  PRO 79  66  66  PRO PRO A . n 
A 1 80  CYS 80  67  67  CYS CYS A . n 
A 1 81  ASP 81  68  68  ASP ASP A . n 
A 1 82  VAL 82  69  69  VAL VAL A . n 
A 1 83  ARG 83  70  70  ARG ARG A . n 
A 1 84  ASP 84  71  71  ASP ASP A . n 
A 1 85  ILE 85  72  72  ILE ILE A . n 
A 1 86  GLU 86  73  73  GLU GLU A . n 
A 1 87  ARG 87  74  74  ARG ARG A . n 
A 1 88  LEU 88  75  75  LEU LEU A . n 
A 1 89  LYS 89  76  76  LYS LYS A . n 
A 1 90  ALA 90  77  77  ALA ALA A . n 
A 1 91  CYS 91  78  78  CYS CYS A . n 
A 1 92  VAL 92  79  79  VAL VAL A . n 
A 1 93  ALA 93  80  80  ALA ALA A . n 
A 1 94  GLU 94  81  81  GLU GLU A . n 
A 1 95  VAL 95  82  82  VAL VAL A . n 
A 1 96  GLU 96  83  83  GLU GLU A . n 
A 1 97  ARG 97  84  84  ARG ARG A . n 
A 1 98  THR 98  85  85  THR THR A . n 
A 1 99  TRP 99  86  86  TRP TRP A . n 
A 1 100 GLY 100 87  87  GLY GLY A . n 
A 1 101 ALA 101 88  88  ALA ALA A . n 
A 1 102 VAL 102 89  89  VAL VAL A . n 
A 1 103 ASP 103 90  90  ASP ASP A . n 
A 1 104 VAL 104 91  91  VAL VAL A . n 
A 1 105 LEU 105 92  92  LEU LEU A . n 
A 1 106 ILE 106 93  93  ILE ILE A . n 
A 1 107 ASN 107 94  94  ASN ASN A . n 
A 1 108 ASN 108 95  95  ASN ASN A . n 
A 1 109 ALA 109 96  96  ALA ALA A . n 
A 1 110 ALA 110 97  97  ALA ALA A . n 
A 1 111 ARG 111 98  98  ARG ARG A . n 
A 1 112 ASP 112 99  99  ASP ASP A . n 
A 1 113 ASP 113 100 100 ASP ASP A . n 
A 1 114 ARG 114 101 101 ARG ARG A . n 
A 1 115 HIS 115 102 102 HIS HIS A . n 
A 1 116 ALA 116 103 103 ALA ALA A . n 
A 1 117 LEU 117 104 104 LEU LEU A . n 
A 1 118 ALA 118 105 105 ALA ALA A . n 
A 1 119 ASP 119 106 106 ASP ASP A . n 
A 1 120 VAL 120 107 107 VAL VAL A . n 
A 1 121 SER 121 108 108 SER SER A . n 
A 1 122 VAL 122 109 109 VAL VAL A . n 
A 1 123 GLU 123 110 110 GLU GLU A . n 
A 1 124 TYR 124 111 111 TYR TYR A . n 
A 1 125 TRP 125 112 112 TRP TRP A . n 
A 1 126 ASP 126 113 113 ASP ASP A . n 
A 1 127 GLU 127 114 114 GLU GLU A . n 
A 1 128 ARG 128 115 115 ARG ARG A . n 
A 1 129 MET 129 116 116 MET MET A . n 
A 1 130 GLN 130 117 117 GLN GLN A . n 
A 1 131 THR 131 118 118 THR THR A . n 
A 1 132 ASN 132 119 119 ASN ASN A . n 
A 1 133 LEU 133 120 120 LEU LEU A . n 
A 1 134 ARG 134 121 121 ARG ARG A . n 
A 1 135 HIS 135 122 122 HIS HIS A . n 
A 1 136 ALA 136 123 123 ALA ALA A . n 
A 1 137 PHE 137 124 124 PHE PHE A . n 
A 1 138 PHE 138 125 125 PHE PHE A . n 
A 1 139 ALA 139 126 126 ALA ALA A . n 
A 1 140 ALA 140 127 127 ALA ALA A . n 
A 1 141 GLN 141 128 128 GLN GLN A . n 
A 1 142 ALA 142 129 129 ALA ALA A . n 
A 1 143 VAL 143 130 130 VAL VAL A . n 
A 1 144 ALA 144 131 131 ALA ALA A . n 
A 1 145 PRO 145 132 132 PRO PRO A . n 
A 1 146 GLY 146 133 133 GLY GLY A . n 
A 1 147 MET 147 134 134 MET MET A . n 
A 1 148 ALA 148 135 135 ALA ALA A . n 
A 1 149 ARG 149 136 136 ARG ARG A . n 
A 1 150 ARG 150 137 137 ARG ARG A . n 
A 1 151 GLY 151 138 138 GLY GLY A . n 
A 1 152 SER 152 139 139 SER SER A . n 
A 1 153 GLY 153 140 140 GLY GLY A . n 
A 1 154 ALA 154 141 141 ALA ALA A . n 
A 1 155 ILE 155 142 142 ILE ILE A . n 
A 1 156 ILE 156 143 143 ILE ILE A . n 
A 1 157 ASN 157 144 144 ASN ASN A . n 
A 1 158 MET 158 145 145 MET MET A . n 
A 1 159 GLY 159 146 146 GLY GLY A . n 
A 1 160 SER 160 147 147 SER SER A . n 
A 1 161 ILE 161 148 148 ILE ILE A . n 
A 1 162 SER 162 149 149 SER SER A . n 
A 1 163 TRP 163 150 150 TRP TRP A . n 
A 1 164 MET 164 151 151 MET MET A . n 
A 1 165 ARG 165 152 152 ARG ARG A . n 
A 1 166 GLY 166 153 153 GLY GLY A . n 
A 1 167 ARG 167 154 154 ARG ARG A . n 
A 1 168 PRO 168 155 155 PRO PRO A . n 
A 1 169 GLY 169 156 156 GLY GLY A . n 
A 1 170 MET 170 157 157 MET MET A . n 
A 1 171 VAL 171 158 158 VAL VAL A . n 
A 1 172 CYS 172 159 159 CYS CYS A . n 
A 1 173 TYR 173 160 160 TYR TYR A . n 
A 1 174 THR 174 161 161 THR THR A . n 
A 1 175 THR 175 162 162 THR THR A . n 
A 1 176 ALA 176 163 163 ALA ALA A . n 
A 1 177 LYS 177 164 164 LYS LYS A . n 
A 1 178 ALA 178 165 165 ALA ALA A . n 
A 1 179 ALA 179 166 166 ALA ALA A . n 
A 1 180 LEU 180 167 167 LEU LEU A . n 
A 1 181 ASN 181 168 168 ASN ASN A . n 
A 1 182 GLY 182 169 169 GLY GLY A . n 
A 1 183 MET 183 170 170 MET MET A . n 
A 1 184 THR 184 171 171 THR THR A . n 
A 1 185 ARG 185 172 172 ARG ARG A . n 
A 1 186 THR 186 173 173 THR THR A . n 
A 1 187 LEU 187 174 174 LEU LEU A . n 
A 1 188 ALA 188 175 175 ALA ALA A . n 
A 1 189 ARG 189 176 176 ARG ARG A . n 
A 1 190 GLU 190 177 177 GLU GLU A . n 
A 1 191 LEU 191 178 178 LEU LEU A . n 
A 1 192 GLY 192 179 179 GLY GLY A . n 
A 1 193 GLY 193 180 180 GLY GLY A . n 
A 1 194 GLN 194 181 181 GLN GLN A . n 
A 1 195 GLY 195 182 182 GLY GLY A . n 
A 1 196 ILE 196 183 183 ILE ILE A . n 
A 1 197 ARG 197 184 184 ARG ARG A . n 
A 1 198 ILE 198 185 185 ILE ILE A . n 
A 1 199 ASN 199 186 186 ASN ASN A . n 
A 1 200 SER 200 187 187 SER SER A . n 
A 1 201 LEU 201 188 188 LEU LEU A . n 
A 1 202 VAL 202 189 189 VAL VAL A . n 
A 1 203 PRO 203 190 190 PRO PRO A . n 
A 1 204 GLY 204 191 191 GLY GLY A . n 
A 1 205 ALA 205 192 192 ALA ALA A . n 
A 1 206 ILE 206 193 193 ILE ILE A . n 
A 1 207 ARG 207 194 194 ARG ARG A . n 
A 1 208 THR 208 195 195 THR THR A . n 
A 1 209 GLU 209 196 196 GLU GLU A . n 
A 1 210 ARG 210 197 197 ARG ARG A . n 
A 1 211 GLN 211 198 198 GLN GLN A . n 
A 1 212 ASP 212 199 199 ASP ASP A . n 
A 1 213 ALA 213 200 200 ALA ALA A . n 
A 1 214 MET 214 201 ?   ?   ?   A . n 
A 1 215 TRP 215 202 ?   ?   ?   A . n 
A 1 216 ALA 216 203 ?   ?   ?   A . n 
A 1 217 ALA 217 204 ?   ?   ?   A . n 
A 1 218 ASP 218 205 ?   ?   ?   A . n 
A 1 219 PRO 219 206 ?   ?   ?   A . n 
A 1 220 ALA 220 207 207 ALA ALA A . n 
A 1 221 GLY 221 208 208 GLY GLY A . n 
A 1 222 LEU 222 209 209 LEU LEU A . n 
A 1 223 GLU 223 210 210 GLU GLU A . n 
A 1 224 ALA 224 211 211 ALA ALA A . n 
A 1 225 ALA 225 212 212 ALA ALA A . n 
A 1 226 SER 226 213 213 SER SER A . n 
A 1 227 GLN 227 214 214 GLN GLN A . n 
A 1 228 ALA 228 215 215 ALA ALA A . n 
A 1 229 PHE 229 216 216 PHE PHE A . n 
A 1 230 ILE 230 217 217 ILE ILE A . n 
A 1 231 ASP 231 218 218 ASP ASP A . n 
A 1 232 GLN 232 219 219 GLN GLN A . n 
A 1 233 GLN 233 220 220 GLN GLN A . n 
A 1 234 MET 234 221 221 MET MET A . n 
A 1 235 LEU 235 222 222 LEU LEU A . n 
A 1 236 LYS 236 223 223 LYS LYS A . n 
A 1 237 PHE 237 224 224 PHE PHE A . n 
A 1 238 ARG 238 225 225 ARG ARG A . n 
A 1 239 LEU 239 226 226 LEU LEU A . n 
A 1 240 ASP 240 227 227 ASP ASP A . n 
A 1 241 ALA 241 228 228 ALA ALA A . n 
A 1 242 SER 242 229 229 SER SER A . n 
A 1 243 ASP 243 230 230 ASP ASP A . n 
A 1 244 CYS 244 231 231 CYS CYS A . n 
A 1 245 ALA 245 232 232 ALA ALA A . n 
A 1 246 ARG 246 233 233 ARG ARG A . n 
A 1 247 LEU 247 234 234 LEU LEU A . n 
A 1 248 ALA 248 235 235 ALA ALA A . n 
A 1 249 LEU 249 236 236 LEU LEU A . n 
A 1 250 PHE 250 237 237 PHE PHE A . n 
A 1 251 LEU 251 238 238 LEU LEU A . n 
A 1 252 ALA 252 239 239 ALA ALA A . n 
A 1 253 SER 253 240 240 SER SER A . n 
A 1 254 ASP 254 241 241 ASP ASP A . n 
A 1 255 ASP 255 242 242 ASP ASP A . n 
A 1 256 SER 256 243 243 SER SER A . n 
A 1 257 ARG 257 244 244 ARG ARG A . n 
A 1 258 GLY 258 245 245 GLY GLY A . n 
A 1 259 CYS 259 246 246 CYS CYS A . n 
A 1 260 THR 260 247 247 THR THR A . n 
A 1 261 GLY 261 248 248 GLY GLY A . n 
A 1 262 GLN 262 249 249 GLN GLN A . n 
A 1 263 ASN 263 250 250 ASN ASN A . n 
A 1 264 PHE 264 251 251 PHE PHE A . n 
A 1 265 VAL 265 252 252 VAL VAL A . n 
A 1 266 VAL 266 253 253 VAL VAL A . n 
A 1 267 ASP 267 254 254 ASP ASP A . n 
A 1 268 ALA 268 255 255 ALA ALA A . n 
A 1 269 GLY 269 256 256 GLY GLY A . n 
A 1 270 LEU 270 257 257 LEU LEU A . n 
A 1 271 SER 271 258 258 SER SER A . n 
A 1 272 ILE 272 259 259 ILE ILE A . n 
A 1 273 GLN 273 260 260 GLN GLN A . n 
B 1 1   MET 1   -12 ?   ?   ?   B . n 
B 1 2   GLY 2   -11 ?   ?   ?   B . n 
B 1 3   SER 3   -10 ?   ?   ?   B . n 
B 1 4   SER 4   -9  ?   ?   ?   B . n 
B 1 5   HIS 5   -8  ?   ?   ?   B . n 
B 1 6   HIS 6   -7  ?   ?   ?   B . n 
B 1 7   HIS 7   -6  ?   ?   ?   B . n 
B 1 8   HIS 8   -5  ?   ?   ?   B . n 
B 1 9   HIS 9   -4  ?   ?   ?   B . n 
B 1 10  HIS 10  -3  ?   ?   ?   B . n 
B 1 11  SER 11  -2  -2  SER SER B . n 
B 1 12  SER 12  -1  -1  SER SER B . n 
B 1 13  GLY 13  0   0   GLY GLY B . n 
B 1 14  MET 14  1   1   MET MET B . n 
B 1 15  ASN 15  2   2   ASN ASN B . n 
B 1 16  ARG 16  3   3   ARG ARG B . n 
B 1 17  HIS 17  4   4   HIS HIS B . n 
B 1 18  THR 18  5   5   THR THR B . n 
B 1 19  ASP 19  6   6   ASP ASP B . n 
B 1 20  THR 20  7   7   THR THR B . n 
B 1 21  HIS 21  8   8   HIS HIS B . n 
B 1 22  TYR 22  9   9   TYR TYR B . n 
B 1 23  PRO 23  10  10  PRO PRO B . n 
B 1 24  SER 24  11  11  SER SER B . n 
B 1 25  LEU 25  12  12  LEU LEU B . n 
B 1 26  ALA 26  13  13  ALA ALA B . n 
B 1 27  ASP 27  14  14  ASP ASP B . n 
B 1 28  LYS 28  15  15  LYS LYS B . n 
B 1 29  VAL 29  16  16  VAL VAL B . n 
B 1 30  VAL 30  17  17  VAL VAL B . n 
B 1 31  LEU 31  18  18  LEU LEU B . n 
B 1 32  ILE 32  19  19  ILE ILE B . n 
B 1 33  SER 33  20  20  SER SER B . n 
B 1 34  GLY 34  21  21  GLY GLY B . n 
B 1 35  GLY 35  22  22  GLY GLY B . n 
B 1 36  ALA 36  23  23  ALA ALA B . n 
B 1 37  SER 37  24  24  SER SER B . n 
B 1 38  GLY 38  25  25  GLY GLY B . n 
B 1 39  ILE 39  26  26  ILE ILE B . n 
B 1 40  GLY 40  27  27  GLY GLY B . n 
B 1 41  ARG 41  28  28  ARG ARG B . n 
B 1 42  ALA 42  29  29  ALA ALA B . n 
B 1 43  PHE 43  30  30  PHE PHE B . n 
B 1 44  VAL 44  31  31  VAL VAL B . n 
B 1 45  GLU 45  32  32  GLU GLU B . n 
B 1 46  ALA 46  33  33  ALA ALA B . n 
B 1 47  PHE 47  34  34  PHE PHE B . n 
B 1 48  VAL 48  35  35  VAL VAL B . n 
B 1 49  ALA 49  36  36  ALA ALA B . n 
B 1 50  GLN 50  37  37  GLN GLN B . n 
B 1 51  GLY 51  38  38  GLY GLY B . n 
B 1 52  SER 52  39  39  SER SER B . n 
B 1 53  ARG 53  40  40  ARG ARG B . n 
B 1 54  VAL 54  41  41  VAL VAL B . n 
B 1 55  ALA 55  42  42  ALA ALA B . n 
B 1 56  PHE 56  43  43  PHE PHE B . n 
B 1 57  LEU 57  44  44  LEU LEU B . n 
B 1 58  ASP 58  45  45  ASP ASP B . n 
B 1 59  LEU 59  46  46  LEU LEU B . n 
B 1 60  ASP 60  47  47  ASP ASP B . n 
B 1 61  ALA 61  48  48  ALA ALA B . n 
B 1 62  GLU 62  49  49  GLU GLU B . n 
B 1 63  ALA 63  50  50  ALA ALA B . n 
B 1 64  GLY 64  51  51  GLY GLY B . n 
B 1 65  GLN 65  52  52  GLN GLN B . n 
B 1 66  GLY 66  53  53  GLY GLY B . n 
B 1 67  LEU 67  54  54  LEU LEU B . n 
B 1 68  ALA 68  55  55  ALA ALA B . n 
B 1 69  HIS 69  56  56  HIS HIS B . n 
B 1 70  ALA 70  57  57  ALA ALA B . n 
B 1 71  LEU 71  58  58  LEU LEU B . n 
B 1 72  GLY 72  59  59  GLY GLY B . n 
B 1 73  ALA 73  60  60  ALA ALA B . n 
B 1 74  ASN 74  61  61  ASN ASN B . n 
B 1 75  SER 75  62  62  SER SER B . n 
B 1 76  LEU 76  63  63  LEU LEU B . n 
B 1 77  PHE 77  64  64  PHE PHE B . n 
B 1 78  LEU 78  65  65  LEU LEU B . n 
B 1 79  PRO 79  66  66  PRO PRO B . n 
B 1 80  CYS 80  67  67  CYS CYS B . n 
B 1 81  ASP 81  68  68  ASP ASP B . n 
B 1 82  VAL 82  69  69  VAL VAL B . n 
B 1 83  ARG 83  70  70  ARG ARG B . n 
B 1 84  ASP 84  71  71  ASP ASP B . n 
B 1 85  ILE 85  72  72  ILE ILE B . n 
B 1 86  GLU 86  73  73  GLU GLU B . n 
B 1 87  ARG 87  74  74  ARG ARG B . n 
B 1 88  LEU 88  75  75  LEU LEU B . n 
B 1 89  LYS 89  76  76  LYS LYS B . n 
B 1 90  ALA 90  77  77  ALA ALA B . n 
B 1 91  CYS 91  78  78  CYS CYS B . n 
B 1 92  VAL 92  79  79  VAL VAL B . n 
B 1 93  ALA 93  80  80  ALA ALA B . n 
B 1 94  GLU 94  81  81  GLU GLU B . n 
B 1 95  VAL 95  82  82  VAL VAL B . n 
B 1 96  GLU 96  83  83  GLU GLU B . n 
B 1 97  ARG 97  84  84  ARG ARG B . n 
B 1 98  THR 98  85  85  THR THR B . n 
B 1 99  TRP 99  86  86  TRP TRP B . n 
B 1 100 GLY 100 87  87  GLY GLY B . n 
B 1 101 ALA 101 88  88  ALA ALA B . n 
B 1 102 VAL 102 89  89  VAL VAL B . n 
B 1 103 ASP 103 90  90  ASP ASP B . n 
B 1 104 VAL 104 91  91  VAL VAL B . n 
B 1 105 LEU 105 92  92  LEU LEU B . n 
B 1 106 ILE 106 93  93  ILE ILE B . n 
B 1 107 ASN 107 94  94  ASN ASN B . n 
B 1 108 ASN 108 95  95  ASN ASN B . n 
B 1 109 ALA 109 96  96  ALA ALA B . n 
B 1 110 ALA 110 97  97  ALA ALA B . n 
B 1 111 ARG 111 98  98  ARG ARG B . n 
B 1 112 ASP 112 99  99  ASP ASP B . n 
B 1 113 ASP 113 100 100 ASP ASP B . n 
B 1 114 ARG 114 101 101 ARG ARG B . n 
B 1 115 HIS 115 102 102 HIS HIS B . n 
B 1 116 ALA 116 103 103 ALA ALA B . n 
B 1 117 LEU 117 104 104 LEU LEU B . n 
B 1 118 ALA 118 105 105 ALA ALA B . n 
B 1 119 ASP 119 106 106 ASP ASP B . n 
B 1 120 VAL 120 107 107 VAL VAL B . n 
B 1 121 SER 121 108 108 SER SER B . n 
B 1 122 VAL 122 109 109 VAL VAL B . n 
B 1 123 GLU 123 110 110 GLU GLU B . n 
B 1 124 TYR 124 111 111 TYR TYR B . n 
B 1 125 TRP 125 112 112 TRP TRP B . n 
B 1 126 ASP 126 113 113 ASP ASP B . n 
B 1 127 GLU 127 114 114 GLU GLU B . n 
B 1 128 ARG 128 115 115 ARG ARG B . n 
B 1 129 MET 129 116 116 MET MET B . n 
B 1 130 GLN 130 117 117 GLN GLN B . n 
B 1 131 THR 131 118 118 THR THR B . n 
B 1 132 ASN 132 119 119 ASN ASN B . n 
B 1 133 LEU 133 120 120 LEU LEU B . n 
B 1 134 ARG 134 121 121 ARG ARG B . n 
B 1 135 HIS 135 122 122 HIS HIS B . n 
B 1 136 ALA 136 123 123 ALA ALA B . n 
B 1 137 PHE 137 124 124 PHE PHE B . n 
B 1 138 PHE 138 125 125 PHE PHE B . n 
B 1 139 ALA 139 126 126 ALA ALA B . n 
B 1 140 ALA 140 127 127 ALA ALA B . n 
B 1 141 GLN 141 128 128 GLN GLN B . n 
B 1 142 ALA 142 129 129 ALA ALA B . n 
B 1 143 VAL 143 130 130 VAL VAL B . n 
B 1 144 ALA 144 131 131 ALA ALA B . n 
B 1 145 PRO 145 132 132 PRO PRO B . n 
B 1 146 GLY 146 133 133 GLY GLY B . n 
B 1 147 MET 147 134 134 MET MET B . n 
B 1 148 ALA 148 135 135 ALA ALA B . n 
B 1 149 ARG 149 136 136 ARG ARG B . n 
B 1 150 ARG 150 137 137 ARG ARG B . n 
B 1 151 GLY 151 138 138 GLY GLY B . n 
B 1 152 SER 152 139 139 SER SER B . n 
B 1 153 GLY 153 140 140 GLY GLY B . n 
B 1 154 ALA 154 141 141 ALA ALA B . n 
B 1 155 ILE 155 142 142 ILE ILE B . n 
B 1 156 ILE 156 143 143 ILE ILE B . n 
B 1 157 ASN 157 144 144 ASN ASN B . n 
B 1 158 MET 158 145 145 MET MET B . n 
B 1 159 GLY 159 146 146 GLY GLY B . n 
B 1 160 SER 160 147 147 SER SER B . n 
B 1 161 ILE 161 148 148 ILE ILE B . n 
B 1 162 SER 162 149 149 SER SER B . n 
B 1 163 TRP 163 150 150 TRP TRP B . n 
B 1 164 MET 164 151 151 MET MET B . n 
B 1 165 ARG 165 152 152 ARG ARG B . n 
B 1 166 GLY 166 153 153 GLY GLY B . n 
B 1 167 ARG 167 154 154 ARG ARG B . n 
B 1 168 PRO 168 155 155 PRO PRO B . n 
B 1 169 GLY 169 156 156 GLY GLY B . n 
B 1 170 MET 170 157 157 MET MET B . n 
B 1 171 VAL 171 158 158 VAL VAL B . n 
B 1 172 CYS 172 159 159 CYS CYS B . n 
B 1 173 TYR 173 160 160 TYR TYR B . n 
B 1 174 THR 174 161 161 THR THR B . n 
B 1 175 THR 175 162 162 THR THR B . n 
B 1 176 ALA 176 163 163 ALA ALA B . n 
B 1 177 LYS 177 164 164 LYS LYS B . n 
B 1 178 ALA 178 165 165 ALA ALA B . n 
B 1 179 ALA 179 166 166 ALA ALA B . n 
B 1 180 LEU 180 167 167 LEU LEU B . n 
B 1 181 ASN 181 168 168 ASN ASN B . n 
B 1 182 GLY 182 169 169 GLY GLY B . n 
B 1 183 MET 183 170 170 MET MET B . n 
B 1 184 THR 184 171 171 THR THR B . n 
B 1 185 ARG 185 172 172 ARG ARG B . n 
B 1 186 THR 186 173 173 THR THR B . n 
B 1 187 LEU 187 174 174 LEU LEU B . n 
B 1 188 ALA 188 175 175 ALA ALA B . n 
B 1 189 ARG 189 176 176 ARG ARG B . n 
B 1 190 GLU 190 177 177 GLU GLU B . n 
B 1 191 LEU 191 178 178 LEU LEU B . n 
B 1 192 GLY 192 179 179 GLY GLY B . n 
B 1 193 GLY 193 180 180 GLY GLY B . n 
B 1 194 GLN 194 181 181 GLN GLN B . n 
B 1 195 GLY 195 182 182 GLY GLY B . n 
B 1 196 ILE 196 183 183 ILE ILE B . n 
B 1 197 ARG 197 184 184 ARG ARG B . n 
B 1 198 ILE 198 185 185 ILE ILE B . n 
B 1 199 ASN 199 186 186 ASN ASN B . n 
B 1 200 SER 200 187 187 SER SER B . n 
B 1 201 LEU 201 188 188 LEU LEU B . n 
B 1 202 VAL 202 189 189 VAL VAL B . n 
B 1 203 PRO 203 190 190 PRO PRO B . n 
B 1 204 GLY 204 191 191 GLY GLY B . n 
B 1 205 ALA 205 192 192 ALA ALA B . n 
B 1 206 ILE 206 193 193 ILE ILE B . n 
B 1 207 ARG 207 194 194 ARG ARG B . n 
B 1 208 THR 208 195 195 THR THR B . n 
B 1 209 GLU 209 196 196 GLU GLU B . n 
B 1 210 ARG 210 197 197 ARG ARG B . n 
B 1 211 GLN 211 198 198 GLN GLN B . n 
B 1 212 ASP 212 199 199 ASP ASP B . n 
B 1 213 ALA 213 200 ?   ?   ?   B . n 
B 1 214 MET 214 201 ?   ?   ?   B . n 
B 1 215 TRP 215 202 ?   ?   ?   B . n 
B 1 216 ALA 216 203 ?   ?   ?   B . n 
B 1 217 ALA 217 204 ?   ?   ?   B . n 
B 1 218 ASP 218 205 ?   ?   ?   B . n 
B 1 219 PRO 219 206 ?   ?   ?   B . n 
B 1 220 ALA 220 207 ?   ?   ?   B . n 
B 1 221 GLY 221 208 208 GLY GLY B . n 
B 1 222 LEU 222 209 209 LEU LEU B . n 
B 1 223 GLU 223 210 210 GLU GLU B . n 
B 1 224 ALA 224 211 211 ALA ALA B . n 
B 1 225 ALA 225 212 212 ALA ALA B . n 
B 1 226 SER 226 213 213 SER SER B . n 
B 1 227 GLN 227 214 214 GLN GLN B . n 
B 1 228 ALA 228 215 215 ALA ALA B . n 
B 1 229 PHE 229 216 216 PHE PHE B . n 
B 1 230 ILE 230 217 217 ILE ILE B . n 
B 1 231 ASP 231 218 218 ASP ASP B . n 
B 1 232 GLN 232 219 219 GLN GLN B . n 
B 1 233 GLN 233 220 220 GLN GLN B . n 
B 1 234 MET 234 221 221 MET MET B . n 
B 1 235 LEU 235 222 222 LEU LEU B . n 
B 1 236 LYS 236 223 223 LYS LYS B . n 
B 1 237 PHE 237 224 224 PHE PHE B . n 
B 1 238 ARG 238 225 225 ARG ARG B . n 
B 1 239 LEU 239 226 226 LEU LEU B . n 
B 1 240 ASP 240 227 227 ASP ASP B . n 
B 1 241 ALA 241 228 228 ALA ALA B . n 
B 1 242 SER 242 229 229 SER SER B . n 
B 1 243 ASP 243 230 230 ASP ASP B . n 
B 1 244 CYS 244 231 231 CYS CYS B . n 
B 1 245 ALA 245 232 232 ALA ALA B . n 
B 1 246 ARG 246 233 233 ARG ARG B . n 
B 1 247 LEU 247 234 234 LEU LEU B . n 
B 1 248 ALA 248 235 235 ALA ALA B . n 
B 1 249 LEU 249 236 236 LEU LEU B . n 
B 1 250 PHE 250 237 237 PHE PHE B . n 
B 1 251 LEU 251 238 238 LEU LEU B . n 
B 1 252 ALA 252 239 239 ALA ALA B . n 
B 1 253 SER 253 240 240 SER SER B . n 
B 1 254 ASP 254 241 241 ASP ASP B . n 
B 1 255 ASP 255 242 242 ASP ASP B . n 
B 1 256 SER 256 243 243 SER SER B . n 
B 1 257 ARG 257 244 244 ARG ARG B . n 
B 1 258 GLY 258 245 245 GLY GLY B . n 
B 1 259 CYS 259 246 246 CYS CYS B . n 
B 1 260 THR 260 247 247 THR THR B . n 
B 1 261 GLY 261 248 248 GLY GLY B . n 
B 1 262 GLN 262 249 249 GLN GLN B . n 
B 1 263 ASN 263 250 250 ASN ASN B . n 
B 1 264 PHE 264 251 251 PHE PHE B . n 
B 1 265 VAL 265 252 252 VAL VAL B . n 
B 1 266 VAL 266 253 253 VAL VAL B . n 
B 1 267 ASP 267 254 254 ASP ASP B . n 
B 1 268 ALA 268 255 255 ALA ALA B . n 
B 1 269 GLY 269 256 256 GLY GLY B . n 
B 1 270 LEU 270 257 257 LEU LEU B . n 
B 1 271 SER 271 258 258 SER SER B . n 
B 1 272 ILE 272 259 259 ILE ILE B . n 
B 1 273 GLN 273 260 260 GLN GLN B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        YZT 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   YZT 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 YZT 1  301 288 YZT SQH A . 
D 3 HOH 1  401 158 HOH HOH A . 
D 3 HOH 2  402 25  HOH HOH A . 
D 3 HOH 3  403 162 HOH HOH A . 
D 3 HOH 4  404 36  HOH HOH A . 
D 3 HOH 5  405 159 HOH HOH A . 
D 3 HOH 6  406 81  HOH HOH A . 
D 3 HOH 7  407 109 HOH HOH A . 
D 3 HOH 8  408 9   HOH HOH A . 
D 3 HOH 9  409 40  HOH HOH A . 
D 3 HOH 10 410 72  HOH HOH A . 
D 3 HOH 11 411 131 HOH HOH A . 
D 3 HOH 12 412 114 HOH HOH A . 
D 3 HOH 13 413 41  HOH HOH A . 
D 3 HOH 14 414 126 HOH HOH A . 
D 3 HOH 15 415 157 HOH HOH A . 
D 3 HOH 16 416 18  HOH HOH A . 
D 3 HOH 17 417 19  HOH HOH A . 
D 3 HOH 18 418 84  HOH HOH A . 
D 3 HOH 19 419 64  HOH HOH A . 
D 3 HOH 20 420 68  HOH HOH A . 
D 3 HOH 21 421 47  HOH HOH A . 
D 3 HOH 22 422 88  HOH HOH A . 
D 3 HOH 23 423 90  HOH HOH A . 
D 3 HOH 24 424 1   HOH HOH A . 
D 3 HOH 25 425 70  HOH HOH A . 
D 3 HOH 26 426 52  HOH HOH A . 
D 3 HOH 27 427 24  HOH HOH A . 
D 3 HOH 28 428 21  HOH HOH A . 
D 3 HOH 29 429 89  HOH HOH A . 
D 3 HOH 30 430 42  HOH HOH A . 
D 3 HOH 31 431 141 HOH HOH A . 
D 3 HOH 32 432 82  HOH HOH A . 
D 3 HOH 33 433 14  HOH HOH A . 
D 3 HOH 34 434 73  HOH HOH A . 
D 3 HOH 35 435 39  HOH HOH A . 
D 3 HOH 36 436 5   HOH HOH A . 
D 3 HOH 37 437 98  HOH HOH A . 
D 3 HOH 38 438 75  HOH HOH A . 
D 3 HOH 39 439 4   HOH HOH A . 
D 3 HOH 40 440 17  HOH HOH A . 
D 3 HOH 41 441 113 HOH HOH A . 
D 3 HOH 42 442 56  HOH HOH A . 
D 3 HOH 43 443 27  HOH HOH A . 
D 3 HOH 44 444 8   HOH HOH A . 
D 3 HOH 45 445 43  HOH HOH A . 
D 3 HOH 46 446 62  HOH HOH A . 
D 3 HOH 47 447 79  HOH HOH A . 
D 3 HOH 48 448 50  HOH HOH A . 
D 3 HOH 49 449 104 HOH HOH A . 
D 3 HOH 50 450 59  HOH HOH A . 
D 3 HOH 51 451 116 HOH HOH A . 
D 3 HOH 52 452 139 HOH HOH A . 
D 3 HOH 53 453 119 HOH HOH A . 
D 3 HOH 54 454 51  HOH HOH A . 
D 3 HOH 55 455 6   HOH HOH A . 
D 3 HOH 56 456 148 HOH HOH A . 
D 3 HOH 57 457 124 HOH HOH A . 
D 3 HOH 58 458 45  HOH HOH A . 
D 3 HOH 59 459 37  HOH HOH A . 
D 3 HOH 60 460 31  HOH HOH A . 
D 3 HOH 61 461 134 HOH HOH A . 
D 3 HOH 62 462 97  HOH HOH A . 
D 3 HOH 63 463 96  HOH HOH A . 
D 3 HOH 64 464 16  HOH HOH A . 
D 3 HOH 65 465 147 HOH HOH A . 
D 3 HOH 66 466 122 HOH HOH A . 
D 3 HOH 67 467 91  HOH HOH A . 
D 3 HOH 68 468 38  HOH HOH A . 
D 3 HOH 69 469 76  HOH HOH A . 
D 3 HOH 70 470 118 HOH HOH A . 
D 3 HOH 71 471 57  HOH HOH A . 
D 3 HOH 72 472 95  HOH HOH A . 
D 3 HOH 73 473 65  HOH HOH A . 
D 3 HOH 74 474 86  HOH HOH A . 
D 3 HOH 75 475 94  HOH HOH A . 
D 3 HOH 76 476 101 HOH HOH A . 
D 3 HOH 77 477 143 HOH HOH A . 
D 3 HOH 78 478 115 HOH HOH A . 
D 3 HOH 79 479 150 HOH HOH A . 
D 3 HOH 80 480 153 HOH HOH A . 
D 3 HOH 81 481 146 HOH HOH A . 
D 3 HOH 82 482 87  HOH HOH A . 
D 3 HOH 83 483 149 HOH HOH A . 
E 3 HOH 1  301 160 HOH HOH B . 
E 3 HOH 2  302 99  HOH HOH B . 
E 3 HOH 3  303 13  HOH HOH B . 
E 3 HOH 4  304 107 HOH HOH B . 
E 3 HOH 5  305 11  HOH HOH B . 
E 3 HOH 6  306 53  HOH HOH B . 
E 3 HOH 7  307 10  HOH HOH B . 
E 3 HOH 8  308 20  HOH HOH B . 
E 3 HOH 9  309 78  HOH HOH B . 
E 3 HOH 10 310 161 HOH HOH B . 
E 3 HOH 11 311 22  HOH HOH B . 
E 3 HOH 12 312 132 HOH HOH B . 
E 3 HOH 13 313 58  HOH HOH B . 
E 3 HOH 14 314 23  HOH HOH B . 
E 3 HOH 15 315 103 HOH HOH B . 
E 3 HOH 16 316 30  HOH HOH B . 
E 3 HOH 17 317 2   HOH HOH B . 
E 3 HOH 18 318 7   HOH HOH B . 
E 3 HOH 19 319 142 HOH HOH B . 
E 3 HOH 20 320 120 HOH HOH B . 
E 3 HOH 21 321 48  HOH HOH B . 
E 3 HOH 22 322 71  HOH HOH B . 
E 3 HOH 23 323 129 HOH HOH B . 
E 3 HOH 24 324 44  HOH HOH B . 
E 3 HOH 25 325 32  HOH HOH B . 
E 3 HOH 26 326 33  HOH HOH B . 
E 3 HOH 27 327 102 HOH HOH B . 
E 3 HOH 28 328 105 HOH HOH B . 
E 3 HOH 29 329 136 HOH HOH B . 
E 3 HOH 30 330 67  HOH HOH B . 
E 3 HOH 31 331 15  HOH HOH B . 
E 3 HOH 32 332 110 HOH HOH B . 
E 3 HOH 33 333 112 HOH HOH B . 
E 3 HOH 34 334 3   HOH HOH B . 
E 3 HOH 35 335 144 HOH HOH B . 
E 3 HOH 36 336 26  HOH HOH B . 
E 3 HOH 37 337 49  HOH HOH B . 
E 3 HOH 38 338 28  HOH HOH B . 
E 3 HOH 39 339 130 HOH HOH B . 
E 3 HOH 40 340 127 HOH HOH B . 
E 3 HOH 41 341 66  HOH HOH B . 
E 3 HOH 42 342 12  HOH HOH B . 
E 3 HOH 43 343 145 HOH HOH B . 
E 3 HOH 44 344 54  HOH HOH B . 
E 3 HOH 45 345 34  HOH HOH B . 
E 3 HOH 46 346 133 HOH HOH B . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1   1 Y 1 A SER -2  ? OG  ? A SER 11  OG  
2   1 Y 1 A MET 1   ? CG  ? A MET 14  CG  
3   1 Y 1 A MET 1   ? SD  ? A MET 14  SD  
4   1 Y 1 A MET 1   ? CE  ? A MET 14  CE  
5   1 Y 1 A ARG 3   ? CG  ? A ARG 16  CG  
6   1 Y 1 A ARG 3   ? CD  ? A ARG 16  CD  
7   1 Y 1 A ARG 3   ? NE  ? A ARG 16  NE  
8   1 Y 1 A ARG 3   ? CZ  ? A ARG 16  CZ  
9   1 Y 1 A ARG 3   ? NH1 ? A ARG 16  NH1 
10  1 Y 1 A ARG 3   ? NH2 ? A ARG 16  NH2 
11  1 Y 1 A LYS 76  ? CD  ? A LYS 89  CD  
12  1 Y 1 A LYS 76  ? CE  ? A LYS 89  CE  
13  1 Y 1 A LYS 76  ? NZ  ? A LYS 89  NZ  
14  1 Y 1 A ARG 98  ? CG  ? A ARG 111 CG  
15  1 Y 1 A ARG 98  ? CD  ? A ARG 111 CD  
16  1 Y 1 A ARG 98  ? NE  ? A ARG 111 NE  
17  1 Y 1 A ARG 98  ? CZ  ? A ARG 111 CZ  
18  1 Y 1 A ARG 98  ? NH1 ? A ARG 111 NH1 
19  1 Y 1 A ARG 98  ? NH2 ? A ARG 111 NH2 
20  1 Y 1 A LEU 104 ? CG  ? A LEU 117 CG  
21  1 Y 1 A LEU 104 ? CD1 ? A LEU 117 CD1 
22  1 Y 1 A LEU 104 ? CD2 ? A LEU 117 CD2 
23  1 Y 1 A ARG 136 ? CG  ? A ARG 149 CG  
24  1 Y 1 A ARG 136 ? CD  ? A ARG 149 CD  
25  1 Y 1 A ARG 136 ? NE  ? A ARG 149 NE  
26  1 Y 1 A ARG 136 ? CZ  ? A ARG 149 CZ  
27  1 Y 1 A ARG 136 ? NH1 ? A ARG 149 NH1 
28  1 Y 1 A ARG 136 ? NH2 ? A ARG 149 NH2 
29  1 Y 1 A ARG 194 ? NE  ? A ARG 207 NE  
30  1 Y 1 A ARG 194 ? CZ  ? A ARG 207 CZ  
31  1 Y 1 A ARG 194 ? NH1 ? A ARG 207 NH1 
32  1 Y 1 A ARG 194 ? NH2 ? A ARG 207 NH2 
33  1 Y 1 A GLU 196 ? CG  ? A GLU 209 CG  
34  1 Y 1 A GLU 196 ? CD  ? A GLU 209 CD  
35  1 Y 1 A GLU 196 ? OE1 ? A GLU 209 OE1 
36  1 Y 1 A GLU 196 ? OE2 ? A GLU 209 OE2 
37  1 Y 1 A ARG 197 ? CG  ? A ARG 210 CG  
38  1 Y 1 A ARG 197 ? CD  ? A ARG 210 CD  
39  1 Y 1 A ARG 197 ? NE  ? A ARG 210 NE  
40  1 Y 1 A ARG 197 ? CZ  ? A ARG 210 CZ  
41  1 Y 1 A ARG 197 ? NH1 ? A ARG 210 NH1 
42  1 Y 1 A ARG 197 ? NH2 ? A ARG 210 NH2 
43  1 Y 1 A LEU 209 ? CG  ? A LEU 222 CG  
44  1 Y 1 A LEU 209 ? CD1 ? A LEU 222 CD1 
45  1 Y 1 A LEU 209 ? CD2 ? A LEU 222 CD2 
46  1 Y 1 A GLU 210 ? CD  ? A GLU 223 CD  
47  1 Y 1 A GLU 210 ? OE1 ? A GLU 223 OE1 
48  1 Y 1 A GLU 210 ? OE2 ? A GLU 223 OE2 
49  1 Y 1 A ASP 241 ? O   ? A ASP 254 O   
50  1 Y 1 A ARG 244 ? CD  ? A ARG 257 CD  
51  1 Y 1 A ARG 244 ? NE  ? A ARG 257 NE  
52  1 Y 1 A ARG 244 ? CZ  ? A ARG 257 CZ  
53  1 Y 1 A ARG 244 ? NH1 ? A ARG 257 NH1 
54  1 Y 1 A ARG 244 ? NH2 ? A ARG 257 NH2 
55  1 Y 1 B SER -2  ? OG  ? B SER 11  OG  
56  1 Y 1 B MET 1   ? CG  ? B MET 14  CG  
57  1 Y 1 B MET 1   ? SD  ? B MET 14  SD  
58  1 Y 1 B MET 1   ? CE  ? B MET 14  CE  
59  1 Y 1 B ARG 3   ? NE  ? B ARG 16  NE  
60  1 Y 1 B ARG 3   ? CZ  ? B ARG 16  CZ  
61  1 Y 1 B ARG 3   ? NH1 ? B ARG 16  NH1 
62  1 Y 1 B ARG 3   ? NH2 ? B ARG 16  NH2 
63  1 Y 1 B ASP 14  ? CG  ? B ASP 27  CG  
64  1 Y 1 B ASP 14  ? OD1 ? B ASP 27  OD1 
65  1 Y 1 B ASP 14  ? OD2 ? B ASP 27  OD2 
66  1 Y 1 B GLU 49  ? CG  ? B GLU 62  CG  
67  1 Y 1 B GLU 49  ? CD  ? B GLU 62  CD  
68  1 Y 1 B GLU 49  ? OE1 ? B GLU 62  OE1 
69  1 Y 1 B GLU 49  ? OE2 ? B GLU 62  OE2 
70  1 Y 1 B LEU 54  ? CG  ? B LEU 67  CG  
71  1 Y 1 B LEU 54  ? CD1 ? B LEU 67  CD1 
72  1 Y 1 B LEU 54  ? CD2 ? B LEU 67  CD2 
73  1 Y 1 B LEU 58  ? CG  ? B LEU 71  CG  
74  1 Y 1 B LEU 58  ? CD1 ? B LEU 71  CD1 
75  1 Y 1 B LEU 58  ? CD2 ? B LEU 71  CD2 
76  1 Y 1 B ARG 70  ? NE  ? B ARG 83  NE  
77  1 Y 1 B ARG 70  ? CZ  ? B ARG 83  CZ  
78  1 Y 1 B ARG 70  ? NH1 ? B ARG 83  NH1 
79  1 Y 1 B ARG 70  ? NH2 ? B ARG 83  NH2 
80  1 Y 1 B GLU 73  ? CG  ? B GLU 86  CG  
81  1 Y 1 B GLU 73  ? CD  ? B GLU 86  CD  
82  1 Y 1 B GLU 73  ? OE1 ? B GLU 86  OE1 
83  1 Y 1 B GLU 73  ? OE2 ? B GLU 86  OE2 
84  1 Y 1 B LYS 76  ? CD  ? B LYS 89  CD  
85  1 Y 1 B LYS 76  ? CE  ? B LYS 89  CE  
86  1 Y 1 B LYS 76  ? NZ  ? B LYS 89  NZ  
87  1 Y 1 B GLU 81  ? CG  ? B GLU 94  CG  
88  1 Y 1 B GLU 81  ? CD  ? B GLU 94  CD  
89  1 Y 1 B GLU 81  ? OE1 ? B GLU 94  OE1 
90  1 Y 1 B GLU 81  ? OE2 ? B GLU 94  OE2 
91  1 Y 1 B ARG 84  ? CG  ? B ARG 97  CG  
92  1 Y 1 B ARG 84  ? CD  ? B ARG 97  CD  
93  1 Y 1 B ARG 84  ? NE  ? B ARG 97  NE  
94  1 Y 1 B ARG 84  ? CZ  ? B ARG 97  CZ  
95  1 Y 1 B ARG 84  ? NH1 ? B ARG 97  NH1 
96  1 Y 1 B ARG 84  ? NH2 ? B ARG 97  NH2 
97  1 Y 1 B ARG 98  ? CG  ? B ARG 111 CG  
98  1 Y 1 B ARG 98  ? CD  ? B ARG 111 CD  
99  1 Y 1 B ARG 98  ? NE  ? B ARG 111 NE  
100 1 Y 1 B ARG 98  ? CZ  ? B ARG 111 CZ  
101 1 Y 1 B ARG 98  ? NH1 ? B ARG 111 NH1 
102 1 Y 1 B ARG 98  ? NH2 ? B ARG 111 NH2 
103 1 Y 1 B ASP 100 ? CG  ? B ASP 113 CG  
104 1 Y 1 B ASP 100 ? OD1 ? B ASP 113 OD1 
105 1 Y 1 B ASP 100 ? OD2 ? B ASP 113 OD2 
106 1 Y 1 B ARG 101 ? CG  ? B ARG 114 CG  
107 1 Y 1 B ARG 101 ? CD  ? B ARG 114 CD  
108 1 Y 1 B ARG 101 ? NE  ? B ARG 114 NE  
109 1 Y 1 B ARG 101 ? CZ  ? B ARG 114 CZ  
110 1 Y 1 B ARG 101 ? NH1 ? B ARG 114 NH1 
111 1 Y 1 B ARG 101 ? NH2 ? B ARG 114 NH2 
112 1 Y 1 B LEU 104 ? CG  ? B LEU 117 CG  
113 1 Y 1 B LEU 104 ? CD1 ? B LEU 117 CD1 
114 1 Y 1 B LEU 104 ? CD2 ? B LEU 117 CD2 
115 1 Y 1 B GLU 110 ? CD  ? B GLU 123 CD  
116 1 Y 1 B GLU 110 ? OE1 ? B GLU 123 OE1 
117 1 Y 1 B GLU 110 ? OE2 ? B GLU 123 OE2 
118 1 Y 1 B GLU 114 ? CG  ? B GLU 127 CG  
119 1 Y 1 B GLU 114 ? CD  ? B GLU 127 CD  
120 1 Y 1 B GLU 114 ? OE1 ? B GLU 127 OE1 
121 1 Y 1 B GLU 114 ? OE2 ? B GLU 127 OE2 
122 1 Y 1 B ARG 115 ? CZ  ? B ARG 128 CZ  
123 1 Y 1 B ARG 115 ? NH1 ? B ARG 128 NH1 
124 1 Y 1 B ARG 115 ? NH2 ? B ARG 128 NH2 
125 1 Y 1 B ARG 136 ? CG  ? B ARG 149 CG  
126 1 Y 1 B ARG 136 ? CD  ? B ARG 149 CD  
127 1 Y 1 B ARG 136 ? NE  ? B ARG 149 NE  
128 1 Y 1 B ARG 136 ? CZ  ? B ARG 149 CZ  
129 1 Y 1 B ARG 136 ? NH1 ? B ARG 149 NH1 
130 1 Y 1 B ARG 136 ? NH2 ? B ARG 149 NH2 
131 1 Y 1 B ARG 154 ? CG  ? B ARG 167 CG  
132 1 Y 1 B ARG 154 ? CD  ? B ARG 167 CD  
133 1 Y 1 B ARG 154 ? NE  ? B ARG 167 NE  
134 1 Y 1 B ARG 154 ? CZ  ? B ARG 167 CZ  
135 1 Y 1 B ARG 154 ? NH1 ? B ARG 167 NH1 
136 1 Y 1 B ARG 154 ? NH2 ? B ARG 167 NH2 
137 1 Y 1 B ARG 194 ? NE  ? B ARG 207 NE  
138 1 Y 1 B ARG 194 ? CZ  ? B ARG 207 CZ  
139 1 Y 1 B ARG 194 ? NH1 ? B ARG 207 NH1 
140 1 Y 1 B ARG 194 ? NH2 ? B ARG 207 NH2 
141 1 Y 1 B GLU 196 ? CG  ? B GLU 209 CG  
142 1 Y 1 B GLU 196 ? CD  ? B GLU 209 CD  
143 1 Y 1 B GLU 196 ? OE1 ? B GLU 209 OE1 
144 1 Y 1 B GLU 196 ? OE2 ? B GLU 209 OE2 
145 1 Y 1 B ARG 197 ? CG  ? B ARG 210 CG  
146 1 Y 1 B ARG 197 ? CD  ? B ARG 210 CD  
147 1 Y 1 B ARG 197 ? NE  ? B ARG 210 NE  
148 1 Y 1 B ARG 197 ? CZ  ? B ARG 210 CZ  
149 1 Y 1 B ARG 197 ? NH1 ? B ARG 210 NH1 
150 1 Y 1 B ARG 197 ? NH2 ? B ARG 210 NH2 
151 1 Y 1 B GLN 198 ? CG  ? B GLN 211 CG  
152 1 Y 1 B GLN 198 ? CD  ? B GLN 211 CD  
153 1 Y 1 B GLN 198 ? OE1 ? B GLN 211 OE1 
154 1 Y 1 B GLN 198 ? NE2 ? B GLN 211 NE2 
155 1 Y 1 B ASP 199 ? CG  ? B ASP 212 CG  
156 1 Y 1 B ASP 199 ? OD1 ? B ASP 212 OD1 
157 1 Y 1 B ASP 199 ? OD2 ? B ASP 212 OD2 
158 1 Y 1 B LEU 209 ? CG  ? B LEU 222 CG  
159 1 Y 1 B LEU 209 ? CD1 ? B LEU 222 CD1 
160 1 Y 1 B LEU 209 ? CD2 ? B LEU 222 CD2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC  ? ? ? 5.8.0430 1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .        2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? xia2    ? ? ? .        3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? BALBES  ? ? ? .        4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   93.12 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9GWW 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     82.869 
_cell.length_a_esd                 ? 
_cell.length_b                     57.290 
_cell.length_b_esd                 ? 
_cell.length_c                     91.979 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9GWW 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                5 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'I 1 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9GWW 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             ? 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          33.83 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
;Binary SQDH-SQ complex was obtained by soaking the sulfonate ligand on a crystal of apo_SQ grown using a 20 mg/mL protein solution in 50 mM TRIS buffer pH 7.5 containing 300 mM NaCl in a drop with 0.15 uL protein: 0.15 uL mother liquor, the latter comprising 0.1 M Magnesium formate dihydrate and 15% w/v PEG 3350
;
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-11-10 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.9763 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'DIAMOND BEAMLINE I03' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.9763 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   I03 
_diffrn_source.pdbx_synchrotron_site       Diamond 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9GWW 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.90 
_reflns.d_resolution_low                               63.21 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     33364 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           97.8 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                6.3 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          11.8 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               0.94 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.087 
_reflns.pdbx_Rpim_I_all                                0.034 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       209259 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.080 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.90 
_reflns_shell.d_res_low                                     1.94 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           12795 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2182 
_reflns_shell.percent_possible_obs                          99.5 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               5.9 
_reflns_shell.pdbx_chi_squared                              0.83 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     2.1 
_reflns_shell.pdbx_Rrim_I_all                               0.839 
_reflns_shell.pdbx_Rpim_I_all                               0.343 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.815 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.764 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            -3.03 
_refine.aniso_B[1][2]                            0.00 
_refine.aniso_B[1][3]                            0.35 
_refine.aniso_B[2][2]                            4.31 
_refine.aniso_B[2][3]                            0.00 
_refine.aniso_B[3][3]                            -1.31 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               36.661 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.953 
_refine.correlation_coeff_Fo_to_Fc_free          0.931 
_refine.details                                  'HYDROGENS HAVE BEEN USED IF PRESENT IN THE INPUT' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9GWW 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.90 
_refine.ls_d_res_low                             48.66 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     31712 
_refine.ls_number_reflns_R_free                  1645 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    97.76 
_refine.ls_percent_reflns_R_free                 4.9 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.22906 
_refine.ls_R_factor_R_free                       0.27845 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.22650 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.213 
_refine.pdbx_overall_ESU_R_Free                  0.188 
_refine.pdbx_solvent_vdw_probe_radii             1.20 
_refine.pdbx_solvent_ion_probe_radii             0.80 
_refine.pdbx_solvent_shrinkage_radii             0.80 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             6.624 
_refine.overall_SU_ML                            0.180 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         1 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.90 
_refine_hist.d_res_low                        48.66 
_refine_hist.number_atoms_solvent             129 
_refine_hist.number_atoms_total               3818 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3674 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         15 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.008  0.012  3743 ? r_bond_refined_d             ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_bond_other_d               ? ? 
'X-RAY DIFFRACTION' ? 1.710  1.770  5076 ? r_angle_refined_deg          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_angle_other_deg            ? ? 
'X-RAY DIFFRACTION' ? 6.536  5.000  508  ? r_dihedral_angle_1_deg       ? ? 
'X-RAY DIFFRACTION' ? 10.131 5.000  28   ? r_dihedral_angle_2_deg       ? ? 
'X-RAY DIFFRACTION' ? 13.381 10.000 549  ? r_dihedral_angle_3_deg       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_dihedral_angle_4_deg       ? ? 
'X-RAY DIFFRACTION' ? 0.112  0.200  586  ? r_chiral_restr               ? ? 
'X-RAY DIFFRACTION' ? 0.008  0.020  2868 ? r_gen_planes_refined         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_gen_planes_other           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbd_refined                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbd_other                  ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbtor_refined              ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_nbtor_other                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_xyhbond_nbd_refined        ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_xyhbond_nbd_other          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_metal_ion_refined          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_metal_ion_other            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_vdw_refined       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_vdw_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_hbond_refined     ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_hbond_other       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_metal_ion_refined ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_symmetry_metal_ion_other   ? ? 
'X-RAY DIFFRACTION' ? 3.753  3.573  2043 ? r_mcbond_it                  ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_mcbond_other               ? ? 
'X-RAY DIFFRACTION' ? 4.852  6.399  2546 ? r_mcangle_it                 ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_mcangle_other              ? ? 
'X-RAY DIFFRACTION' ? 4.647  3.714  1700 ? r_scbond_it                  ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_scbond_other               ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_scangle_it                 ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_scangle_other              ? ? 
'X-RAY DIFFRACTION' ? 7.115  41.91  5706 ? r_long_range_B_refined       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_long_range_B_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_rigid_bond_restr           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_sphericity_free            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?    ? r_sphericity_bonded          ? ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.d_res_high                       1.900 
_refine_ls_shell.d_res_low                        1.949 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.number_reflns_obs                ? 
_refine_ls_shell.number_reflns_R_free             127 
_refine_ls_shell.number_reflns_R_work             2360 
_refine_ls_shell.percent_reflns_obs               99.52 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.R_factor_R_work                  0.375 
_refine_ls_shell.redundancy_reflns_all            ? 
_refine_ls_shell.redundancy_reflns_obs            ? 
_refine_ls_shell.wR_factor_all                    ? 
_refine_ls_shell.wR_factor_obs                    ? 
_refine_ls_shell.wR_factor_R_free                 ? 
_refine_ls_shell.wR_factor_R_work                 ? 
_refine_ls_shell.pdbx_R_complete                  ? 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.pdbx_phase_error                 ? 
_refine_ls_shell.pdbx_fsc_work                    ? 
_refine_ls_shell.pdbx_fsc_free                    ? 
_refine_ls_shell.R_factor_R_free                  0.399 
# 
_struct.entry_id                     9GWW 
_struct.title                        
;Crystal structure of sulfoquinovose-1-dehydrogenase from Pseudomonas Putida in complex with sulfoquinovose substrate (sulfo-ED pathway)
;
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9GWW 
_struct_keywords.text            
'sulfoquinovose; sulfoglycolysis; sulfosugar, short-chain dehydrogenase-reductase; enzyme-substrate complex, OXIDOREDUCTASE' 
_struct_keywords.pdbx_keywords   OXIDOREDUCTASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 3 ? 
E N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    SQD_PSEPU 
_struct_ref.pdbx_db_accession          P0DOV5 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MNRHTDTHYPSLADKVVLISGGASGIGRAFVEAFVAQGSRVAFLDLDAEAGQGLAHALGANSLFLPCDVRDIERLKACVA
EVERTWGAVDVLINNAARDDRHALADVSVEYWDERMQTNLRHAFFAAQAVAPGMARRGSGAIINMGSISWMRGRPGMVCY
TTAKAALNGMTRTLARELGGQGIRINSLVPGAIRTERQDAMWAADPAGLEAASQAFIDQQMLKFRLDASDCARLALFLAS
DDSRGCTGQNFVVDAGLSIQ
;
_struct_ref.pdbx_align_begin           1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9GWW A 14 ? 273 ? P0DOV5 1 ? 260 ? 1 260 
2 1 9GWW B 14 ? 273 ? P0DOV5 1 ? 260 ? 1 260 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9GWW MET A 1  ? UNP P0DOV5 ? ? 'initiating methionine' -12 1  
1 9GWW GLY A 2  ? UNP P0DOV5 ? ? 'expression tag'        -11 2  
1 9GWW SER A 3  ? UNP P0DOV5 ? ? 'expression tag'        -10 3  
1 9GWW SER A 4  ? UNP P0DOV5 ? ? 'expression tag'        -9  4  
1 9GWW HIS A 5  ? UNP P0DOV5 ? ? 'expression tag'        -8  5  
1 9GWW HIS A 6  ? UNP P0DOV5 ? ? 'expression tag'        -7  6  
1 9GWW HIS A 7  ? UNP P0DOV5 ? ? 'expression tag'        -6  7  
1 9GWW HIS A 8  ? UNP P0DOV5 ? ? 'expression tag'        -5  8  
1 9GWW HIS A 9  ? UNP P0DOV5 ? ? 'expression tag'        -4  9  
1 9GWW HIS A 10 ? UNP P0DOV5 ? ? 'expression tag'        -3  10 
1 9GWW SER A 11 ? UNP P0DOV5 ? ? 'expression tag'        -2  11 
1 9GWW SER A 12 ? UNP P0DOV5 ? ? 'expression tag'        -1  12 
1 9GWW GLY A 13 ? UNP P0DOV5 ? ? 'expression tag'        0   13 
2 9GWW MET B 1  ? UNP P0DOV5 ? ? 'initiating methionine' -12 14 
2 9GWW GLY B 2  ? UNP P0DOV5 ? ? 'expression tag'        -11 15 
2 9GWW SER B 3  ? UNP P0DOV5 ? ? 'expression tag'        -10 16 
2 9GWW SER B 4  ? UNP P0DOV5 ? ? 'expression tag'        -9  17 
2 9GWW HIS B 5  ? UNP P0DOV5 ? ? 'expression tag'        -8  18 
2 9GWW HIS B 6  ? UNP P0DOV5 ? ? 'expression tag'        -7  19 
2 9GWW HIS B 7  ? UNP P0DOV5 ? ? 'expression tag'        -6  20 
2 9GWW HIS B 8  ? UNP P0DOV5 ? ? 'expression tag'        -5  21 
2 9GWW HIS B 9  ? UNP P0DOV5 ? ? 'expression tag'        -4  22 
2 9GWW HIS B 10 ? UNP P0DOV5 ? ? 'expression tag'        -3  23 
2 9GWW SER B 11 ? UNP P0DOV5 ? ? 'expression tag'        -2  24 
2 9GWW SER B 12 ? UNP P0DOV5 ? ? 'expression tag'        -1  25 
2 9GWW GLY B 13 ? UNP P0DOV5 ? ? 'expression tag'        0   26 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   tetrameric 
_pdbx_struct_assembly.oligomeric_count     4 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 13560 ? 
1 MORE         -72   ? 
1 'SSA (A^2)'  32160 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                'SEC-MALLS confirmed tetramer in solution' 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z     1.0000000000  0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  0.0000000000   
2 'crystal symmetry operation' 2_554 -x,y,-z-1 -1.0000000000 0.0000000000 0.0000000000 5.0061745810 0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 -91.8426625108 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 TYR A 22  ? ALA A 26  ? TYR A 9   ALA A 13  5 ? 5  
HELX_P HELX_P2  AA2 SER A 37  ? ALA A 49  ? SER A 24  ALA A 36  1 ? 13 
HELX_P HELX_P3  AA3 ASP A 60  ? GLY A 72  ? ASP A 47  GLY A 59  1 ? 13 
HELX_P HELX_P4  AA4 ASP A 84  ? GLY A 100 ? ASP A 71  GLY A 87  1 ? 17 
HELX_P HELX_P5  AA5 ALA A 116 ? VAL A 120 ? ALA A 103 VAL A 107 5 ? 5  
HELX_P HELX_P6  AA6 SER A 121 ? LEU A 133 ? SER A 108 LEU A 120 1 ? 13 
HELX_P HELX_P7  AA7 LEU A 133 ? GLY A 151 ? LEU A 120 GLY A 138 1 ? 19 
HELX_P HELX_P8  AA8 MET A 170 ? GLY A 193 ? MET A 157 GLY A 180 1 ? 24 
HELX_P HELX_P9  AA9 THR A 208 ? ALA A 213 ? THR A 195 ALA A 200 1 ? 6  
HELX_P HELX_P10 AB1 GLY A 221 ? GLN A 233 ? GLY A 208 GLN A 220 1 ? 13 
HELX_P HELX_P11 AB2 ALA A 241 ? SER A 253 ? ALA A 228 SER A 240 1 ? 13 
HELX_P HELX_P12 AB3 TYR B 22  ? ALA B 26  ? TYR B 9   ALA B 13  5 ? 5  
HELX_P HELX_P13 AB4 SER B 37  ? ALA B 49  ? SER B 24  ALA B 36  1 ? 13 
HELX_P HELX_P14 AB5 ASP B 60  ? GLY B 72  ? ASP B 47  GLY B 59  1 ? 13 
HELX_P HELX_P15 AB6 ASP B 84  ? GLY B 100 ? ASP B 71  GLY B 87  1 ? 17 
HELX_P HELX_P16 AB7 ALA B 116 ? VAL B 120 ? ALA B 103 VAL B 107 5 ? 5  
HELX_P HELX_P17 AB8 SER B 121 ? LEU B 133 ? SER B 108 LEU B 120 1 ? 13 
HELX_P HELX_P18 AB9 LEU B 133 ? GLY B 151 ? LEU B 120 GLY B 138 1 ? 19 
HELX_P HELX_P19 AC1 SER B 160 ? ARG B 165 ? SER B 147 ARG B 152 1 ? 6  
HELX_P HELX_P20 AC2 MET B 170 ? GLY B 193 ? MET B 157 GLY B 180 1 ? 24 
HELX_P HELX_P21 AC3 LEU B 222 ? GLN B 233 ? LEU B 209 GLN B 220 1 ? 12 
HELX_P HELX_P22 AC4 ALA B 241 ? SER B 253 ? ALA B 228 SER B 240 1 ? 13 
HELX_P HELX_P23 AC5 ASP B 254 ? ARG B 257 ? ASP B 241 ARG B 244 5 ? 4  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 2 ? 
AA3 ? 7 ? 
AA4 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel 
AA1 2 3 ? parallel 
AA1 3 4 ? parallel 
AA1 4 5 ? parallel 
AA1 5 6 ? parallel 
AA1 6 7 ? parallel 
AA2 1 2 ? parallel 
AA3 1 2 ? parallel 
AA3 2 3 ? parallel 
AA3 3 4 ? parallel 
AA3 4 5 ? parallel 
AA3 5 6 ? parallel 
AA3 6 7 ? parallel 
AA4 1 2 ? parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 SER A 75  ? PRO A 79  ? SER A 62  PRO A 66  
AA1 2 ARG A 53  ? ASP A 58  ? ARG A 40  ASP A 45  
AA1 3 VAL A 29  ? ILE A 32  ? VAL A 16  ILE A 19  
AA1 4 VAL A 104 ? ASN A 107 ? VAL A 91  ASN A 94  
AA1 5 GLY A 153 ? MET A 158 ? GLY A 140 MET A 145 
AA1 6 ILE A 196 ? PRO A 203 ? ILE A 183 PRO A 190 
AA1 7 ASN A 263 ? VAL A 266 ? ASN A 250 VAL A 253 
AA2 1 ILE A 206 ? ARG A 207 ? ILE A 193 ARG A 194 
AA2 2 LEU A 239 ? ASP A 240 ? LEU A 226 ASP A 227 
AA3 1 SER B 75  ? PRO B 79  ? SER B 62  PRO B 66  
AA3 2 ARG B 53  ? ASP B 58  ? ARG B 40  ASP B 45  
AA3 3 VAL B 29  ? ILE B 32  ? VAL B 16  ILE B 19  
AA3 4 VAL B 104 ? ASN B 107 ? VAL B 91  ASN B 94  
AA3 5 GLY B 153 ? MET B 158 ? GLY B 140 MET B 145 
AA3 6 ILE B 196 ? PRO B 203 ? ILE B 183 PRO B 190 
AA3 7 ASN B 263 ? VAL B 266 ? ASN B 250 VAL B 253 
AA4 1 ILE B 206 ? ARG B 207 ? ILE B 193 ARG B 194 
AA4 2 LEU B 239 ? ASP B 240 ? LEU B 226 ASP B 227 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O LEU A 78  ? O LEU A 65  N PHE A 56  ? N PHE A 43  
AA1 2 3 O ALA A 55  ? O ALA A 42  N VAL A 30  ? N VAL A 17  
AA1 3 4 N LEU A 31  ? N LEU A 18  O ILE A 106 ? O ILE A 93  
AA1 4 5 N LEU A 105 ? N LEU A 92  O ILE A 156 ? O ILE A 143 
AA1 5 6 N ASN A 157 ? N ASN A 144 O ASN A 199 ? O ASN A 186 
AA1 6 7 N VAL A 202 ? N VAL A 189 O PHE A 264 ? O PHE A 251 
AA2 1 2 N ARG A 207 ? N ARG A 194 O LEU A 239 ? O LEU A 226 
AA3 1 2 O LEU B 78  ? O LEU B 65  N PHE B 56  ? N PHE B 43  
AA3 2 3 O ALA B 55  ? O ALA B 42  N VAL B 30  ? N VAL B 17  
AA3 3 4 N LEU B 31  ? N LEU B 18  O ILE B 106 ? O ILE B 93  
AA3 4 5 N LEU B 105 ? N LEU B 92  O ILE B 156 ? O ILE B 143 
AA3 5 6 N ASN B 157 ? N ASN B 144 O ASN B 199 ? O ASN B 186 
AA3 6 7 N VAL B 202 ? N VAL B 189 O PHE B 264 ? O PHE B 251 
AA4 1 2 N ARG B 207 ? N ARG B 194 O LEU B 239 ? O LEU B 226 
# 
_pdbx_entry_details.entry_id                   9GWW 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 O   A HOH 403 ? ? O A HOH 457 ? ? 2.08 
2 1 OD2 A ASP 242 ? ? O A HOH 401 ? ? 2.18 
# 
loop_
_pdbx_validate_rmsd_angle.id 
_pdbx_validate_rmsd_angle.PDB_model_num 
_pdbx_validate_rmsd_angle.auth_atom_id_1 
_pdbx_validate_rmsd_angle.auth_asym_id_1 
_pdbx_validate_rmsd_angle.auth_comp_id_1 
_pdbx_validate_rmsd_angle.auth_seq_id_1 
_pdbx_validate_rmsd_angle.PDB_ins_code_1 
_pdbx_validate_rmsd_angle.label_alt_id_1 
_pdbx_validate_rmsd_angle.auth_atom_id_2 
_pdbx_validate_rmsd_angle.auth_asym_id_2 
_pdbx_validate_rmsd_angle.auth_comp_id_2 
_pdbx_validate_rmsd_angle.auth_seq_id_2 
_pdbx_validate_rmsd_angle.PDB_ins_code_2 
_pdbx_validate_rmsd_angle.label_alt_id_2 
_pdbx_validate_rmsd_angle.auth_atom_id_3 
_pdbx_validate_rmsd_angle.auth_asym_id_3 
_pdbx_validate_rmsd_angle.auth_comp_id_3 
_pdbx_validate_rmsd_angle.auth_seq_id_3 
_pdbx_validate_rmsd_angle.PDB_ins_code_3 
_pdbx_validate_rmsd_angle.label_alt_id_3 
_pdbx_validate_rmsd_angle.angle_value 
_pdbx_validate_rmsd_angle.angle_target_value 
_pdbx_validate_rmsd_angle.angle_deviation 
_pdbx_validate_rmsd_angle.angle_standard_deviation 
_pdbx_validate_rmsd_angle.linker_flag 
1 1 CD A ARG 225 ? ? NE A ARG 225 ? ? CZ  A ARG 225 ? ? 132.52 123.60 8.92  1.40 N 
2 1 CD B ARG 225 ? ? NE B ARG 225 ? ? CZ  B ARG 225 ? ? 132.33 123.60 8.73  1.40 N 
3 1 NE B ARG 225 ? ? CZ B ARG 225 ? ? NH2 B ARG 225 ? ? 116.63 120.30 -3.67 0.50 N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 HIS A 4   ? ? 77.95   -36.04 
2  1 ASP A 14  ? ? 75.18   -2.34  
3  1 LEU A 120 ? ? -126.70 -52.17 
4  1 MET A 157 ? ? -163.64 55.34  
5  1 LYS A 223 ? ? -95.02  54.07  
6  1 HIS B 4   ? ? 80.07   -36.39 
7  1 ASP B 14  ? ? 79.68   -8.22  
8  1 LEU B 120 ? ? -124.91 -50.92 
9  1 MET B 157 ? ? -165.70 54.59  
10 1 LYS B 223 ? ? -93.65  53.75  
# 
loop_
_pdbx_validate_planes.id 
_pdbx_validate_planes.PDB_model_num 
_pdbx_validate_planes.auth_comp_id 
_pdbx_validate_planes.auth_asym_id 
_pdbx_validate_planes.auth_seq_id 
_pdbx_validate_planes.PDB_ins_code 
_pdbx_validate_planes.label_alt_id 
_pdbx_validate_planes.rmsd 
_pdbx_validate_planes.type 
1 1 ARG A 115 ? ? 0.119 'SIDE CHAIN' 
2 1 ARG A 154 ? ? 0.101 'SIDE CHAIN' 
3 1 ARG A 225 ? ? 0.076 'SIDE CHAIN' 
4 1 ARG B 233 ? ? 0.109 'SIDE CHAIN' 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET -12 ? A MET 1   
2  1 Y 1 A GLY -11 ? A GLY 2   
3  1 Y 1 A SER -10 ? A SER 3   
4  1 Y 1 A SER -9  ? A SER 4   
5  1 Y 1 A HIS -8  ? A HIS 5   
6  1 Y 1 A HIS -7  ? A HIS 6   
7  1 Y 1 A HIS -6  ? A HIS 7   
8  1 Y 1 A HIS -5  ? A HIS 8   
9  1 Y 1 A HIS -4  ? A HIS 9   
10 1 Y 1 A HIS -3  ? A HIS 10  
11 1 Y 1 A MET 201 ? A MET 214 
12 1 Y 1 A TRP 202 ? A TRP 215 
13 1 Y 1 A ALA 203 ? A ALA 216 
14 1 Y 1 A ALA 204 ? A ALA 217 
15 1 Y 1 A ASP 205 ? A ASP 218 
16 1 Y 1 A PRO 206 ? A PRO 219 
17 1 Y 1 B MET -12 ? B MET 1   
18 1 Y 1 B GLY -11 ? B GLY 2   
19 1 Y 1 B SER -10 ? B SER 3   
20 1 Y 1 B SER -9  ? B SER 4   
21 1 Y 1 B HIS -8  ? B HIS 5   
22 1 Y 1 B HIS -7  ? B HIS 6   
23 1 Y 1 B HIS -6  ? B HIS 7   
24 1 Y 1 B HIS -5  ? B HIS 8   
25 1 Y 1 B HIS -4  ? B HIS 9   
26 1 Y 1 B HIS -3  ? B HIS 10  
27 1 Y 1 B ALA 200 ? B ALA 213 
28 1 Y 1 B MET 201 ? B MET 214 
29 1 Y 1 B TRP 202 ? B TRP 215 
30 1 Y 1 B ALA 203 ? B ALA 216 
31 1 Y 1 B ALA 204 ? B ALA 217 
32 1 Y 1 B ASP 205 ? B ASP 218 
33 1 Y 1 B PRO 206 ? B PRO 219 
34 1 Y 1 B ALA 207 ? B ALA 220 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
VAL N    N N N 372 
VAL CA   C N S 373 
VAL C    C N N 374 
VAL O    O N N 375 
VAL CB   C N N 376 
VAL CG1  C N N 377 
VAL CG2  C N N 378 
VAL OXT  O N N 379 
VAL H    H N N 380 
VAL H2   H N N 381 
VAL HA   H N N 382 
VAL HB   H N N 383 
VAL HG11 H N N 384 
VAL HG12 H N N 385 
VAL HG13 H N N 386 
VAL HG21 H N N 387 
VAL HG22 H N N 388 
VAL HG23 H N N 389 
VAL HXT  H N N 390 
YZT C1   C N R 391 
YZT C2   C N R 392 
YZT C3   C N S 393 
YZT C4   C N S 394 
YZT C5   C N S 395 
YZT C6   C N N 396 
YZT O1   O N N 397 
YZT O1S6 O N N 398 
YZT O2   O N N 399 
YZT O2S6 O N N 400 
YZT O3   O N N 401 
YZT O3S6 O N N 402 
YZT O4   O N N 403 
YZT O5   O N N 404 
YZT S6   S N N 405 
YZT H1   H N N 406 
YZT H1O  H N N 407 
YZT H1S6 H N N 408 
YZT H2   H N N 409 
YZT H2O  H N N 410 
YZT H3   H N N 411 
YZT H3O  H N N 412 
YZT H4   H N N 413 
YZT H4O  H N N 414 
YZT H5   H N N 415 
YZT H61  H N N 416 
YZT H62  H N N 417 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N    CA   sing N N 1   
ALA N    H    sing N N 2   
ALA N    H2   sing N N 3   
ALA CA   C    sing N N 4   
ALA CA   CB   sing N N 5   
ALA CA   HA   sing N N 6   
ALA C    O    doub N N 7   
ALA C    OXT  sing N N 8   
ALA CB   HB1  sing N N 9   
ALA CB   HB2  sing N N 10  
ALA CB   HB3  sing N N 11  
ALA OXT  HXT  sing N N 12  
ARG N    CA   sing N N 13  
ARG N    H    sing N N 14  
ARG N    H2   sing N N 15  
ARG CA   C    sing N N 16  
ARG CA   CB   sing N N 17  
ARG CA   HA   sing N N 18  
ARG C    O    doub N N 19  
ARG C    OXT  sing N N 20  
ARG CB   CG   sing N N 21  
ARG CB   HB2  sing N N 22  
ARG CB   HB3  sing N N 23  
ARG CG   CD   sing N N 24  
ARG CG   HG2  sing N N 25  
ARG CG   HG3  sing N N 26  
ARG CD   NE   sing N N 27  
ARG CD   HD2  sing N N 28  
ARG CD   HD3  sing N N 29  
ARG NE   CZ   sing N N 30  
ARG NE   HE   sing N N 31  
ARG CZ   NH1  sing N N 32  
ARG CZ   NH2  doub N N 33  
ARG NH1  HH11 sing N N 34  
ARG NH1  HH12 sing N N 35  
ARG NH2  HH21 sing N N 36  
ARG NH2  HH22 sing N N 37  
ARG OXT  HXT  sing N N 38  
ASN N    CA   sing N N 39  
ASN N    H    sing N N 40  
ASN N    H2   sing N N 41  
ASN CA   C    sing N N 42  
ASN CA   CB   sing N N 43  
ASN CA   HA   sing N N 44  
ASN C    O    doub N N 45  
ASN C    OXT  sing N N 46  
ASN CB   CG   sing N N 47  
ASN CB   HB2  sing N N 48  
ASN CB   HB3  sing N N 49  
ASN CG   OD1  doub N N 50  
ASN CG   ND2  sing N N 51  
ASN ND2  HD21 sing N N 52  
ASN ND2  HD22 sing N N 53  
ASN OXT  HXT  sing N N 54  
ASP N    CA   sing N N 55  
ASP N    H    sing N N 56  
ASP N    H2   sing N N 57  
ASP CA   C    sing N N 58  
ASP CA   CB   sing N N 59  
ASP CA   HA   sing N N 60  
ASP C    O    doub N N 61  
ASP C    OXT  sing N N 62  
ASP CB   CG   sing N N 63  
ASP CB   HB2  sing N N 64  
ASP CB   HB3  sing N N 65  
ASP CG   OD1  doub N N 66  
ASP CG   OD2  sing N N 67  
ASP OD2  HD2  sing N N 68  
ASP OXT  HXT  sing N N 69  
CYS N    CA   sing N N 70  
CYS N    H    sing N N 71  
CYS N    H2   sing N N 72  
CYS CA   C    sing N N 73  
CYS CA   CB   sing N N 74  
CYS CA   HA   sing N N 75  
CYS C    O    doub N N 76  
CYS C    OXT  sing N N 77  
CYS CB   SG   sing N N 78  
CYS CB   HB2  sing N N 79  
CYS CB   HB3  sing N N 80  
CYS SG   HG   sing N N 81  
CYS OXT  HXT  sing N N 82  
GLN N    CA   sing N N 83  
GLN N    H    sing N N 84  
GLN N    H2   sing N N 85  
GLN CA   C    sing N N 86  
GLN CA   CB   sing N N 87  
GLN CA   HA   sing N N 88  
GLN C    O    doub N N 89  
GLN C    OXT  sing N N 90  
GLN CB   CG   sing N N 91  
GLN CB   HB2  sing N N 92  
GLN CB   HB3  sing N N 93  
GLN CG   CD   sing N N 94  
GLN CG   HG2  sing N N 95  
GLN CG   HG3  sing N N 96  
GLN CD   OE1  doub N N 97  
GLN CD   NE2  sing N N 98  
GLN NE2  HE21 sing N N 99  
GLN NE2  HE22 sing N N 100 
GLN OXT  HXT  sing N N 101 
GLU N    CA   sing N N 102 
GLU N    H    sing N N 103 
GLU N    H2   sing N N 104 
GLU CA   C    sing N N 105 
GLU CA   CB   sing N N 106 
GLU CA   HA   sing N N 107 
GLU C    O    doub N N 108 
GLU C    OXT  sing N N 109 
GLU CB   CG   sing N N 110 
GLU CB   HB2  sing N N 111 
GLU CB   HB3  sing N N 112 
GLU CG   CD   sing N N 113 
GLU CG   HG2  sing N N 114 
GLU CG   HG3  sing N N 115 
GLU CD   OE1  doub N N 116 
GLU CD   OE2  sing N N 117 
GLU OE2  HE2  sing N N 118 
GLU OXT  HXT  sing N N 119 
GLY N    CA   sing N N 120 
GLY N    H    sing N N 121 
GLY N    H2   sing N N 122 
GLY CA   C    sing N N 123 
GLY CA   HA2  sing N N 124 
GLY CA   HA3  sing N N 125 
GLY C    O    doub N N 126 
GLY C    OXT  sing N N 127 
GLY OXT  HXT  sing N N 128 
HIS N    CA   sing N N 129 
HIS N    H    sing N N 130 
HIS N    H2   sing N N 131 
HIS CA   C    sing N N 132 
HIS CA   CB   sing N N 133 
HIS CA   HA   sing N N 134 
HIS C    O    doub N N 135 
HIS C    OXT  sing N N 136 
HIS CB   CG   sing N N 137 
HIS CB   HB2  sing N N 138 
HIS CB   HB3  sing N N 139 
HIS CG   ND1  sing Y N 140 
HIS CG   CD2  doub Y N 141 
HIS ND1  CE1  doub Y N 142 
HIS ND1  HD1  sing N N 143 
HIS CD2  NE2  sing Y N 144 
HIS CD2  HD2  sing N N 145 
HIS CE1  NE2  sing Y N 146 
HIS CE1  HE1  sing N N 147 
HIS NE2  HE2  sing N N 148 
HIS OXT  HXT  sing N N 149 
HOH O    H1   sing N N 150 
HOH O    H2   sing N N 151 
ILE N    CA   sing N N 152 
ILE N    H    sing N N 153 
ILE N    H2   sing N N 154 
ILE CA   C    sing N N 155 
ILE CA   CB   sing N N 156 
ILE CA   HA   sing N N 157 
ILE C    O    doub N N 158 
ILE C    OXT  sing N N 159 
ILE CB   CG1  sing N N 160 
ILE CB   CG2  sing N N 161 
ILE CB   HB   sing N N 162 
ILE CG1  CD1  sing N N 163 
ILE CG1  HG12 sing N N 164 
ILE CG1  HG13 sing N N 165 
ILE CG2  HG21 sing N N 166 
ILE CG2  HG22 sing N N 167 
ILE CG2  HG23 sing N N 168 
ILE CD1  HD11 sing N N 169 
ILE CD1  HD12 sing N N 170 
ILE CD1  HD13 sing N N 171 
ILE OXT  HXT  sing N N 172 
LEU N    CA   sing N N 173 
LEU N    H    sing N N 174 
LEU N    H2   sing N N 175 
LEU CA   C    sing N N 176 
LEU CA   CB   sing N N 177 
LEU CA   HA   sing N N 178 
LEU C    O    doub N N 179 
LEU C    OXT  sing N N 180 
LEU CB   CG   sing N N 181 
LEU CB   HB2  sing N N 182 
LEU CB   HB3  sing N N 183 
LEU CG   CD1  sing N N 184 
LEU CG   CD2  sing N N 185 
LEU CG   HG   sing N N 186 
LEU CD1  HD11 sing N N 187 
LEU CD1  HD12 sing N N 188 
LEU CD1  HD13 sing N N 189 
LEU CD2  HD21 sing N N 190 
LEU CD2  HD22 sing N N 191 
LEU CD2  HD23 sing N N 192 
LEU OXT  HXT  sing N N 193 
LYS N    CA   sing N N 194 
LYS N    H    sing N N 195 
LYS N    H2   sing N N 196 
LYS CA   C    sing N N 197 
LYS CA   CB   sing N N 198 
LYS CA   HA   sing N N 199 
LYS C    O    doub N N 200 
LYS C    OXT  sing N N 201 
LYS CB   CG   sing N N 202 
LYS CB   HB2  sing N N 203 
LYS CB   HB3  sing N N 204 
LYS CG   CD   sing N N 205 
LYS CG   HG2  sing N N 206 
LYS CG   HG3  sing N N 207 
LYS CD   CE   sing N N 208 
LYS CD   HD2  sing N N 209 
LYS CD   HD3  sing N N 210 
LYS CE   NZ   sing N N 211 
LYS CE   HE2  sing N N 212 
LYS CE   HE3  sing N N 213 
LYS NZ   HZ1  sing N N 214 
LYS NZ   HZ2  sing N N 215 
LYS NZ   HZ3  sing N N 216 
LYS OXT  HXT  sing N N 217 
MET N    CA   sing N N 218 
MET N    H    sing N N 219 
MET N    H2   sing N N 220 
MET CA   C    sing N N 221 
MET CA   CB   sing N N 222 
MET CA   HA   sing N N 223 
MET C    O    doub N N 224 
MET C    OXT  sing N N 225 
MET CB   CG   sing N N 226 
MET CB   HB2  sing N N 227 
MET CB   HB3  sing N N 228 
MET CG   SD   sing N N 229 
MET CG   HG2  sing N N 230 
MET CG   HG3  sing N N 231 
MET SD   CE   sing N N 232 
MET CE   HE1  sing N N 233 
MET CE   HE2  sing N N 234 
MET CE   HE3  sing N N 235 
MET OXT  HXT  sing N N 236 
PHE N    CA   sing N N 237 
PHE N    H    sing N N 238 
PHE N    H2   sing N N 239 
PHE CA   C    sing N N 240 
PHE CA   CB   sing N N 241 
PHE CA   HA   sing N N 242 
PHE C    O    doub N N 243 
PHE C    OXT  sing N N 244 
PHE CB   CG   sing N N 245 
PHE CB   HB2  sing N N 246 
PHE CB   HB3  sing N N 247 
PHE CG   CD1  doub Y N 248 
PHE CG   CD2  sing Y N 249 
PHE CD1  CE1  sing Y N 250 
PHE CD1  HD1  sing N N 251 
PHE CD2  CE2  doub Y N 252 
PHE CD2  HD2  sing N N 253 
PHE CE1  CZ   doub Y N 254 
PHE CE1  HE1  sing N N 255 
PHE CE2  CZ   sing Y N 256 
PHE CE2  HE2  sing N N 257 
PHE CZ   HZ   sing N N 258 
PHE OXT  HXT  sing N N 259 
PRO N    CA   sing N N 260 
PRO N    CD   sing N N 261 
PRO N    H    sing N N 262 
PRO CA   C    sing N N 263 
PRO CA   CB   sing N N 264 
PRO CA   HA   sing N N 265 
PRO C    O    doub N N 266 
PRO C    OXT  sing N N 267 
PRO CB   CG   sing N N 268 
PRO CB   HB2  sing N N 269 
PRO CB   HB3  sing N N 270 
PRO CG   CD   sing N N 271 
PRO CG   HG2  sing N N 272 
PRO CG   HG3  sing N N 273 
PRO CD   HD2  sing N N 274 
PRO CD   HD3  sing N N 275 
PRO OXT  HXT  sing N N 276 
SER N    CA   sing N N 277 
SER N    H    sing N N 278 
SER N    H2   sing N N 279 
SER CA   C    sing N N 280 
SER CA   CB   sing N N 281 
SER CA   HA   sing N N 282 
SER C    O    doub N N 283 
SER C    OXT  sing N N 284 
SER CB   OG   sing N N 285 
SER CB   HB2  sing N N 286 
SER CB   HB3  sing N N 287 
SER OG   HG   sing N N 288 
SER OXT  HXT  sing N N 289 
THR N    CA   sing N N 290 
THR N    H    sing N N 291 
THR N    H2   sing N N 292 
THR CA   C    sing N N 293 
THR CA   CB   sing N N 294 
THR CA   HA   sing N N 295 
THR C    O    doub N N 296 
THR C    OXT  sing N N 297 
THR CB   OG1  sing N N 298 
THR CB   CG2  sing N N 299 
THR CB   HB   sing N N 300 
THR OG1  HG1  sing N N 301 
THR CG2  HG21 sing N N 302 
THR CG2  HG22 sing N N 303 
THR CG2  HG23 sing N N 304 
THR OXT  HXT  sing N N 305 
TRP N    CA   sing N N 306 
TRP N    H    sing N N 307 
TRP N    H2   sing N N 308 
TRP CA   C    sing N N 309 
TRP CA   CB   sing N N 310 
TRP CA   HA   sing N N 311 
TRP C    O    doub N N 312 
TRP C    OXT  sing N N 313 
TRP CB   CG   sing N N 314 
TRP CB   HB2  sing N N 315 
TRP CB   HB3  sing N N 316 
TRP CG   CD1  doub Y N 317 
TRP CG   CD2  sing Y N 318 
TRP CD1  NE1  sing Y N 319 
TRP CD1  HD1  sing N N 320 
TRP CD2  CE2  doub Y N 321 
TRP CD2  CE3  sing Y N 322 
TRP NE1  CE2  sing Y N 323 
TRP NE1  HE1  sing N N 324 
TRP CE2  CZ2  sing Y N 325 
TRP CE3  CZ3  doub Y N 326 
TRP CE3  HE3  sing N N 327 
TRP CZ2  CH2  doub Y N 328 
TRP CZ2  HZ2  sing N N 329 
TRP CZ3  CH2  sing Y N 330 
TRP CZ3  HZ3  sing N N 331 
TRP CH2  HH2  sing N N 332 
TRP OXT  HXT  sing N N 333 
TYR N    CA   sing N N 334 
TYR N    H    sing N N 335 
TYR N    H2   sing N N 336 
TYR CA   C    sing N N 337 
TYR CA   CB   sing N N 338 
TYR CA   HA   sing N N 339 
TYR C    O    doub N N 340 
TYR C    OXT  sing N N 341 
TYR CB   CG   sing N N 342 
TYR CB   HB2  sing N N 343 
TYR CB   HB3  sing N N 344 
TYR CG   CD1  doub Y N 345 
TYR CG   CD2  sing Y N 346 
TYR CD1  CE1  sing Y N 347 
TYR CD1  HD1  sing N N 348 
TYR CD2  CE2  doub Y N 349 
TYR CD2  HD2  sing N N 350 
TYR CE1  CZ   doub Y N 351 
TYR CE1  HE1  sing N N 352 
TYR CE2  CZ   sing Y N 353 
TYR CE2  HE2  sing N N 354 
TYR CZ   OH   sing N N 355 
TYR OH   HH   sing N N 356 
TYR OXT  HXT  sing N N 357 
VAL N    CA   sing N N 358 
VAL N    H    sing N N 359 
VAL N    H2   sing N N 360 
VAL CA   C    sing N N 361 
VAL CA   CB   sing N N 362 
VAL CA   HA   sing N N 363 
VAL C    O    doub N N 364 
VAL C    OXT  sing N N 365 
VAL CB   CG1  sing N N 366 
VAL CB   CG2  sing N N 367 
VAL CB   HB   sing N N 368 
VAL CG1  HG11 sing N N 369 
VAL CG1  HG12 sing N N 370 
VAL CG1  HG13 sing N N 371 
VAL CG2  HG21 sing N N 372 
VAL CG2  HG22 sing N N 373 
VAL CG2  HG23 sing N N 374 
VAL OXT  HXT  sing N N 375 
YZT C1   O1   sing N N 376 
YZT C1   C2   sing N N 377 
YZT C1   O5   sing N N 378 
YZT C1   H1   sing N N 379 
YZT C2   O2   sing N N 380 
YZT C2   C3   sing N N 381 
YZT C2   H2   sing N N 382 
YZT C3   O3   sing N N 383 
YZT C3   C4   sing N N 384 
YZT C3   H3   sing N N 385 
YZT C4   O4   sing N N 386 
YZT C4   C5   sing N N 387 
YZT C4   H4   sing N N 388 
YZT C5   C6   sing N N 389 
YZT C5   H5   sing N N 390 
YZT C5   O5   sing N N 391 
YZT C6   S6   sing N N 392 
YZT C6   H61  sing N N 393 
YZT C6   H62  sing N N 394 
YZT O1   H1O  sing N N 395 
YZT O1S6 H1S6 sing N N 396 
YZT O1S6 S6   sing N N 397 
YZT O2   H2O  sing N N 398 
YZT O2S6 S6   doub N N 399 
YZT O3   H3O  sing N N 400 
YZT O3S6 S6   doub N N 401 
YZT O4   H4O  sing N N 402 
# 
_pdbx_audit_support.funding_organization   'Biotechnology and Biological Sciences Research Council (BBSRC)' 
_pdbx_audit_support.country                'United Kingdom' 
_pdbx_audit_support.grant_number           BB/W003805/1 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'in silico model' 
_pdbx_initial_refinement_model.source_name      AlphaFold 
_pdbx_initial_refinement_model.accession_code   AF-P0DOV5 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9GWW 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.012067 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000658 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.017455 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.010888 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N    . SER A 1 11  ? -6.004  -19.604 -4.665  1.00 58.60  ? -2  SER A N    1 
ATOM   2    C CA   . SER A 1 11  ? -6.434  -20.548 -5.731  1.00 54.05  ? -2  SER A CA   1 
ATOM   3    C C    . SER A 1 11  ? -7.736  -20.053 -6.358  1.00 45.36  ? -2  SER A C    1 
ATOM   4    O O    . SER A 1 11  ? -8.085  -20.464 -7.465  1.00 51.63  ? -2  SER A O    1 
ATOM   5    C CB   . SER A 1 11  ? -6.557  -21.981 -5.224  1.00 41.29  ? -2  SER A CB   1 
ATOM   6    N N    . SER A 1 12  ? -8.465  -19.200 -5.630  1.00 42.23  ? -1  SER A N    1 
ATOM   7    C CA   . SER A 1 12  ? -9.755  -18.728 -6.117  1.00 44.42  ? -1  SER A CA   1 
ATOM   8    C C    . SER A 1 12  ? -9.554  -17.638 -7.175  1.00 52.07  ? -1  SER A C    1 
ATOM   9    O O    . SER A 1 12  ? -10.507 -17.243 -7.849  1.00 46.75  ? -1  SER A O    1 
ATOM   10   C CB   . SER A 1 12  ? -10.656 -18.256 -4.988  1.00 48.67  ? -1  SER A CB   1 
ATOM   11   O OG   . SER A 1 12  ? -10.240 -16.988 -4.507  1.00 47.75  ? -1  SER A OG   1 
ATOM   12   N N    . GLY A 1 13  ? -8.308  -17.156 -7.294  1.00 42.46  ? 0   GLY A N    1 
ATOM   13   C CA   . GLY A 1 13  ? -8.012  -16.082 -8.222  1.00 46.43  ? 0   GLY A CA   1 
ATOM   14   C C    . GLY A 1 13  ? -7.398  -16.589 -9.524  1.00 48.34  ? 0   GLY A C    1 
ATOM   15   O O    . GLY A 1 13  ? -7.074  -15.764 -10.375 1.00 56.99  ? 0   GLY A O    1 
ATOM   16   N N    . MET A 1 14  ? -7.250  -17.925 -9.669  1.00 45.41  ? 1   MET A N    1 
ATOM   17   C CA   . MET A 1 14  ? -6.504  -18.550 -10.760 1.00 44.14  ? 1   MET A CA   1 
ATOM   18   C C    . MET A 1 14  ? -7.333  -18.694 -12.052 1.00 45.93  ? 1   MET A C    1 
ATOM   19   O O    . MET A 1 14  ? -8.481  -19.138 -12.043 1.00 39.93  ? 1   MET A O    1 
ATOM   20   C CB   . MET A 1 14  ? -5.910  -19.895 -10.311 1.00 41.57  ? 1   MET A CB   1 
ATOM   21   N N    . ASN A 1 15  ? -6.718  -18.327 -13.190 1.00 46.05  ? 2   ASN A N    1 
ATOM   22   C CA   . ASN A 1 15  ? -7.223  -18.619 -14.524 1.00 37.61  ? 2   ASN A CA   1 
ATOM   23   C C    . ASN A 1 15  ? -7.383  -20.139 -14.682 1.00 42.88  ? 2   ASN A C    1 
ATOM   24   O O    . ASN A 1 15  ? -6.439  -20.918 -14.466 1.00 42.44  ? 2   ASN A O    1 
ATOM   25   C CB   . ASN A 1 15  ? -6.344  -17.883 -15.527 1.00 34.99  ? 2   ASN A CB   1 
ATOM   26   C CG   . ASN A 1 15  ? -6.908  -17.806 -16.920 1.00 34.99  ? 2   ASN A CG   1 
ATOM   27   O OD1  . ASN A 1 15  ? -7.883  -18.499 -17.252 1.00 35.51  ? 2   ASN A OD1  1 
ATOM   28   N ND2  . ASN A 1 15  ? -6.246  -17.015 -17.760 1.00 34.08  ? 2   ASN A ND2  1 
ATOM   29   N N    . ARG A 1 16  ? -8.611  -20.568 -15.022 1.00 34.77  ? 3   ARG A N    1 
ATOM   30   C CA   . ARG A 1 16  ? -8.912  -21.977 -15.242 1.00 35.71  ? 3   ARG A CA   1 
ATOM   31   C C    . ARG A 1 16  ? -8.729  -22.308 -16.738 1.00 32.01  ? 3   ARG A C    1 
ATOM   32   O O    . ARG A 1 16  ? -8.665  -23.488 -17.137 1.00 27.12  ? 3   ARG A O    1 
ATOM   33   C CB   . ARG A 1 16  ? -10.324 -22.272 -14.707 1.00 38.27  ? 3   ARG A CB   1 
ATOM   34   N N    . HIS A 1 17  ? -8.676  -21.226 -17.556 1.00 33.19  ? 4   HIS A N    1 
ATOM   35   C CA   . HIS A 1 17  ? -8.425  -21.235 -19.003 1.00 31.12  ? 4   HIS A CA   1 
ATOM   36   C C    . HIS A 1 17  ? -9.647  -21.641 -19.825 1.00 30.67  ? 4   HIS A C    1 
ATOM   37   O O    . HIS A 1 17  ? -9.803  -21.159 -20.934 1.00 35.98  ? 4   HIS A O    1 
ATOM   38   C CB   . HIS A 1 17  ? -7.143  -22.018 -19.350 1.00 25.93  ? 4   HIS A CB   1 
ATOM   39   C CG   . HIS A 1 17  ? -5.969  -21.370 -18.687 1.00 29.26  ? 4   HIS A CG   1 
ATOM   40   N ND1  . HIS A 1 17  ? -5.410  -20.235 -19.229 1.00 27.39  ? 4   HIS A ND1  1 
ATOM   41   C CD2  . HIS A 1 17  ? -5.324  -21.598 -17.534 1.00 26.37  ? 4   HIS A CD2  1 
ATOM   42   C CE1  . HIS A 1 17  ? -4.458  -19.794 -18.402 1.00 25.28  ? 4   HIS A CE1  1 
ATOM   43   N NE2  . HIS A 1 17  ? -4.398  -20.590 -17.376 1.00 26.52  ? 4   HIS A NE2  1 
ATOM   44   N N    . THR A 1 18  ? -10.461 -22.575 -19.325 1.00 30.43  ? 5   THR A N    1 
ATOM   45   C CA   . THR A 1 18  ? -11.643 -23.025 -20.056 1.00 33.61  ? 5   THR A CA   1 
ATOM   46   C C    . THR A 1 18  ? -12.757 -23.346 -19.059 1.00 40.68  ? 5   THR A C    1 
ATOM   47   O O    . THR A 1 18  ? -12.466 -23.674 -17.899 1.00 34.57  ? 5   THR A O    1 
ATOM   48   C CB   . THR A 1 18  ? -11.335 -24.259 -20.916 1.00 31.30  ? 5   THR A CB   1 
ATOM   49   O OG1  . THR A 1 18  ? -12.559 -24.538 -21.600 1.00 35.76  ? 5   THR A OG1  1 
ATOM   50   C CG2  . THR A 1 18  ? -10.942 -25.495 -20.129 1.00 28.11  ? 5   THR A CG2  1 
ATOM   51   N N    . ASP A 1 19  ? -14.015 -23.309 -19.545 1.00 32.98  ? 6   ASP A N    1 
ATOM   52   C CA   . ASP A 1 19  ? -15.141 -23.802 -18.769 1.00 38.15  ? 6   ASP A CA   1 
ATOM   53   C C    . ASP A 1 19  ? -15.404 -25.284 -19.074 1.00 39.54  ? 6   ASP A C    1 
ATOM   54   O O    . ASP A 1 19  ? -16.251 -25.917 -18.449 1.00 45.92  ? 6   ASP A O    1 
ATOM   55   C CB   . ASP A 1 19  ? -16.344 -22.874 -18.899 1.00 48.66  ? 6   ASP A CB   1 
ATOM   56   C CG   . ASP A 1 19  ? -16.828 -22.619 -20.324 1.00 52.18  ? 6   ASP A CG   1 
ATOM   57   O OD1  . ASP A 1 19  ? -16.124 -23.028 -21.277 1.00 60.46  ? 6   ASP A OD1  1 
ATOM   58   O OD2  . ASP A 1 19  ? -17.915 -22.025 -20.480 1.00 51.46  ? 6   ASP A OD2  1 
ATOM   59   N N    . THR A 1 20  ? -14.661 -25.871 -20.015 1.00 34.07  ? 7   THR A N    1 
ATOM   60   C CA   . THR A 1 20  ? -14.874 -27.261 -20.362 1.00 32.26  ? 7   THR A CA   1 
ATOM   61   C C    . THR A 1 20  ? -14.442 -28.147 -19.206 1.00 34.54  ? 7   THR A C    1 
ATOM   62   O O    . THR A 1 20  ? -13.481 -27.820 -18.529 1.00 32.56  ? 7   THR A O    1 
ATOM   63   C CB   . THR A 1 20  ? -14.109 -27.610 -21.631 1.00 28.60  ? 7   THR A CB   1 
ATOM   64   O OG1  . THR A 1 20  ? -14.849 -26.834 -22.548 1.00 32.20  ? 7   THR A OG1  1 
ATOM   65   C CG2  . THR A 1 20  ? -14.279 -29.059 -22.047 1.00 32.07  ? 7   THR A CG2  1 
ATOM   66   N N    . HIS A 1 21  ? -15.094 -29.316 -19.075 1.00 35.79  ? 8   HIS A N    1 
ATOM   67   C CA   . HIS A 1 21  ? -14.702 -30.278 -18.061 1.00 34.44  ? 8   HIS A CA   1 
ATOM   68   C C    . HIS A 1 21  ? -14.356 -31.609 -18.711 1.00 33.66  ? 8   HIS A C    1 
ATOM   69   O O    . HIS A 1 21  ? -15.203 -32.229 -19.351 1.00 32.48  ? 8   HIS A O    1 
ATOM   70   C CB   . HIS A 1 21  ? -15.769 -30.442 -16.961 1.00 40.38  ? 8   HIS A CB   1 
ATOM   71   C CG   . HIS A 1 21  ? -15.421 -31.500 -15.953 1.00 45.84  ? 8   HIS A CG   1 
ATOM   72   N ND1  . HIS A 1 21  ? -16.289 -32.506 -15.573 1.00 54.32  ? 8   HIS A ND1  1 
ATOM   73   C CD2  . HIS A 1 21  ? -14.279 -31.748 -15.301 1.00 50.60  ? 8   HIS A CD2  1 
ATOM   74   C CE1  . HIS A 1 21  ? -15.691 -33.316 -14.707 1.00 55.06  ? 8   HIS A CE1  1 
ATOM   75   N NE2  . HIS A 1 21  ? -14.463 -32.873 -14.524 1.00 59.40  ? 8   HIS A NE2  1 
ATOM   76   N N    . TYR A 1 22  ? -13.114 -32.060 -18.492 1.00 29.64  ? 9   TYR A N    1 
ATOM   77   C CA   . TYR A 1 22  ? -12.654 -33.326 -19.021 1.00 31.31  ? 9   TYR A CA   1 
ATOM   78   C C    . TYR A 1 22  ? -12.513 -34.293 -17.859 1.00 34.41  ? 9   TYR A C    1 
ATOM   79   O O    . TYR A 1 22  ? -11.498 -34.306 -17.172 1.00 35.01  ? 9   TYR A O    1 
ATOM   80   C CB   . TYR A 1 22  ? -11.331 -33.260 -19.789 1.00 32.40  ? 9   TYR A CB   1 
ATOM   81   C CG   . TYR A 1 22  ? -11.288 -32.335 -21.003 1.00 32.62  ? 9   TYR A CG   1 
ATOM   82   C CD1  . TYR A 1 22  ? -11.016 -30.986 -20.858 1.00 30.13  ? 9   TYR A CD1  1 
ATOM   83   C CD2  . TYR A 1 22  ? -11.463 -32.826 -22.289 1.00 31.79  ? 9   TYR A CD2  1 
ATOM   84   C CE1  . TYR A 1 22  ? -10.924 -30.153 -21.955 1.00 34.96  ? 9   TYR A CE1  1 
ATOM   85   C CE2  . TYR A 1 22  ? -11.345 -32.012 -23.404 1.00 30.04  ? 9   TYR A CE2  1 
ATOM   86   C CZ   . TYR A 1 22  ? -11.066 -30.675 -23.228 1.00 33.55  ? 9   TYR A CZ   1 
ATOM   87   O OH   . TYR A 1 22  ? -11.027 -29.855 -24.307 1.00 32.75  ? 9   TYR A OH   1 
ATOM   88   N N    . PRO A 1 23  ? -13.520 -35.152 -17.613 1.00 34.30  ? 10  PRO A N    1 
ATOM   89   C CA   . PRO A 1 23  ? -13.415 -36.131 -16.542 1.00 35.28  ? 10  PRO A CA   1 
ATOM   90   C C    . PRO A 1 23  ? -12.174 -37.005 -16.653 1.00 33.99  ? 10  PRO A C    1 
ATOM   91   O O    . PRO A 1 23  ? -11.581 -37.340 -15.623 1.00 42.75  ? 10  PRO A O    1 
ATOM   92   C CB   . PRO A 1 23  ? -14.730 -36.952 -16.602 1.00 37.24  ? 10  PRO A CB   1 
ATOM   93   C CG   . PRO A 1 23  ? -15.642 -36.088 -17.464 1.00 36.28  ? 10  PRO A CG   1 
ATOM   94   C CD   . PRO A 1 23  ? -14.808 -35.191 -18.330 1.00 32.92  ? 10  PRO A CD   1 
ATOM   95   N N    . SER A 1 24  ? -11.776 -37.357 -17.891 1.00 29.54  ? 11  SER A N    1 
ATOM   96   C CA   . SER A 1 24  ? -10.611 -38.219 -18.097 1.00 29.73  ? 11  SER A CA   1 
ATOM   97   C C    . SER A 1 24  ? -9.292  -37.598 -17.599 1.00 28.73  ? 11  SER A C    1 
ATOM   98   O O    . SER A 1 24  ? -8.286  -38.293 -17.509 1.00 27.87  ? 11  SER A O    1 
ATOM   99   C CB   . SER A 1 24  ? -10.496 -38.615 -19.525 1.00 27.35  ? 11  SER A CB   1 
ATOM   100  O OG   . SER A 1 24  ? -10.463 -37.413 -20.295 1.00 31.02  ? 11  SER A OG   1 
ATOM   101  N N    . LEU A 1 25  ? -9.271  -36.283 -17.325 1.00 28.15  ? 12  LEU A N    1 
ATOM   102  C CA   . LEU A 1 25  ? -8.054  -35.623 -16.862 1.00 32.60  ? 12  LEU A CA   1 
ATOM   103  C C    . LEU A 1 25  ? -7.858  -35.716 -15.338 1.00 38.33  ? 12  LEU A C    1 
ATOM   104  O O    . LEU A 1 25  ? -6.724  -35.597 -14.836 1.00 32.96  ? 12  LEU A O    1 
ATOM   105  C CB   . LEU A 1 25  ? -7.996  -34.173 -17.357 1.00 29.78  ? 12  LEU A CB   1 
ATOM   106  C CG   . LEU A 1 25  ? -7.743  -34.022 -18.866 1.00 26.94  ? 12  LEU A CG   1 
ATOM   107  C CD1  . LEU A 1 25  ? -7.571  -32.542 -19.233 1.00 28.07  ? 12  LEU A CD1  1 
ATOM   108  C CD2  . LEU A 1 25  ? -6.531  -34.838 -19.300 1.00 21.89  ? 12  LEU A CD2  1 
ATOM   109  N N    . ALA A 1 26  ? -8.944  -35.943 -14.589 1.00 36.48  ? 13  ALA A N    1 
ATOM   110  C CA   . ALA A 1 26  ? -8.849  -36.029 -13.137 1.00 35.69  ? 13  ALA A CA   1 
ATOM   111  C C    . ALA A 1 26  ? -7.808  -37.060 -12.742 1.00 33.19  ? 13  ALA A C    1 
ATOM   112  O O    . ALA A 1 26  ? -7.835  -38.186 -13.257 1.00 36.53  ? 13  ALA A O    1 
ATOM   113  C CB   . ALA A 1 26  ? -10.204 -36.333 -12.512 1.00 37.40  ? 13  ALA A CB   1 
ATOM   114  N N    . ASP A 1 27  ? -6.896  -36.655 -11.830 1.00 34.61  ? 14  ASP A N    1 
ATOM   115  C CA   . ASP A 1 27  ? -5.929  -37.555 -11.217 1.00 40.03  ? 14  ASP A CA   1 
ATOM   116  C C    . ASP A 1 27  ? -4.778  -37.943 -12.140 1.00 39.68  ? 14  ASP A C    1 
ATOM   117  O O    . ASP A 1 27  ? -3.879  -38.679 -11.726 1.00 41.63  ? 14  ASP A O    1 
ATOM   118  C CB   . ASP A 1 27  ? -6.618  -38.797 -10.676 1.00 47.27  ? 14  ASP A CB   1 
ATOM   119  C CG   . ASP A 1 27  ? -7.570  -38.514 -9.520  1.00 53.12  ? 14  ASP A CG   1 
ATOM   120  O OD1  . ASP A 1 27  ? -7.149  -37.828 -8.563  1.00 49.33  ? 14  ASP A OD1  1 
ATOM   121  O OD2  . ASP A 1 27  ? -8.728  -38.968 -9.588  1.00 52.23  ? 14  ASP A OD2  1 
ATOM   122  N N    . LYS A 1 28  ? -4.804  -37.470 -13.391 1.00 37.72  ? 15  LYS A N    1 
ATOM   123  C CA   . LYS A 1 28  ? -3.747  -37.837 -14.317 1.00 36.73  ? 15  LYS A CA   1 
ATOM   124  C C    . LYS A 1 28  ? -2.497  -37.073 -13.902 1.00 31.82  ? 15  LYS A C    1 
ATOM   125  O O    . LYS A 1 28  ? -2.598  -35.929 -13.454 1.00 31.34  ? 15  LYS A O    1 
ATOM   126  C CB   . LYS A 1 28  ? -4.153  -37.546 -15.769 1.00 41.74  ? 15  LYS A CB   1 
ATOM   127  C CG   . LYS A 1 28  ? -5.246  -38.412 -16.377 1.00 43.65  ? 15  LYS A CG   1 
ATOM   128  C CD   . LYS A 1 28  ? -4.820  -39.834 -16.735 1.00 51.30  ? 15  LYS A CD   1 
ATOM   129  C CE   . LYS A 1 28  ? -5.955  -40.825 -16.890 1.00 54.36  ? 15  LYS A CE   1 
ATOM   130  N NZ   . LYS A 1 28  ? -6.929  -40.371 -17.893 1.00 56.12  ? 15  LYS A NZ   1 
ATOM   131  N N    . VAL A 1 29  ? -1.338  -37.719 -14.073 1.00 30.91  ? 16  VAL A N    1 
ATOM   132  C CA   . VAL A 1 29  ? -0.037  -37.151 -13.768 1.00 27.66  ? 16  VAL A CA   1 
ATOM   133  C C    . VAL A 1 29  ? 0.493   -36.430 -15.012 1.00 29.58  ? 16  VAL A C    1 
ATOM   134  O O    . VAL A 1 29  ? 0.804   -37.070 -16.020 1.00 31.27  ? 16  VAL A O    1 
ATOM   135  C CB   . VAL A 1 29  ? 0.951   -38.230 -13.277 1.00 35.40  ? 16  VAL A CB   1 
ATOM   136  C CG1  . VAL A 1 29  ? 2.339   -37.660 -12.958 1.00 30.54  ? 16  VAL A CG1  1 
ATOM   137  C CG2  . VAL A 1 29  ? 0.426   -38.992 -12.064 1.00 32.93  ? 16  VAL A CG2  1 
ATOM   138  N N    . VAL A 1 30  ? 0.647   -35.098 -14.891 1.00 28.71  ? 17  VAL A N    1 
ATOM   139  C CA   . VAL A 1 30  ? 1.041   -34.239 -15.987 1.00 27.31  ? 17  VAL A CA   1 
ATOM   140  C C    . VAL A 1 30  ? 2.392   -33.619 -15.634 1.00 28.03  ? 17  VAL A C    1 
ATOM   141  O O    . VAL A 1 30  ? 2.566   -33.110 -14.541 1.00 32.39  ? 17  VAL A O    1 
ATOM   142  C CB   . VAL A 1 30  ? -0.045  -33.171 -16.239 1.00 27.52  ? 17  VAL A CB   1 
ATOM   143  C CG1  . VAL A 1 30  ? 0.326   -32.223 -17.372 1.00 28.09  ? 17  VAL A CG1  1 
ATOM   144  C CG2  . VAL A 1 30  ? -1.376  -33.799 -16.601 1.00 26.04  ? 17  VAL A CG2  1 
ATOM   145  N N    . LEU A 1 31  ? 3.352   -33.702 -16.569 1.00 27.06  ? 18  LEU A N    1 
ATOM   146  C CA   . LEU A 1 31  ? 4.686   -33.167 -16.399 1.00 29.78  ? 18  LEU A CA   1 
ATOM   147  C C    . LEU A 1 31  ? 4.984   -32.137 -17.491 1.00 24.78  ? 18  LEU A C    1 
ATOM   148  O O    . LEU A 1 31  ? 4.926   -32.456 -18.676 1.00 26.51  ? 18  LEU A O    1 
ATOM   149  C CB   . LEU A 1 31  ? 5.696   -34.313 -16.412 1.00 25.54  ? 18  LEU A CB   1 
ATOM   150  C CG   . LEU A 1 31  ? 7.159   -33.854 -16.299 1.00 28.68  ? 18  LEU A CG   1 
ATOM   151  C CD1  . LEU A 1 31  ? 7.477   -33.094 -15.002 1.00 26.41  ? 18  LEU A CD1  1 
ATOM   152  C CD2  . LEU A 1 31  ? 8.145   -35.020 -16.515 1.00 26.95  ? 18  LEU A CD2  1 
ATOM   153  N N    . ILE A 1 32  ? 5.382   -30.925 -17.096 1.00 28.14  ? 19  ILE A N    1 
ATOM   154  C CA   . ILE A 1 32  ? 5.522   -29.821 -18.050 1.00 25.97  ? 19  ILE A CA   1 
ATOM   155  C C    . ILE A 1 32  ? 6.845   -29.099 -17.810 1.00 31.16  ? 19  ILE A C    1 
ATOM   156  O O    . ILE A 1 32  ? 7.137   -28.730 -16.677 1.00 29.89  ? 19  ILE A O    1 
ATOM   157  C CB   . ILE A 1 32  ? 4.371   -28.834 -17.847 1.00 29.67  ? 19  ILE A CB   1 
ATOM   158  C CG1  . ILE A 1 32  ? 3.005   -29.489 -18.148 1.00 23.39  ? 19  ILE A CG1  1 
ATOM   159  C CG2  . ILE A 1 32  ? 4.620   -27.540 -18.633 1.00 25.53  ? 19  ILE A CG2  1 
ATOM   160  C CD1  . ILE A 1 32  ? 1.862   -28.790 -17.432 1.00 24.74  ? 19  ILE A CD1  1 
ATOM   161  N N    . SER A 1 33  ? 7.634   -28.903 -18.879 1.00 28.79  ? 20  SER A N    1 
ATOM   162  C CA   . SER A 1 33  ? 8.929   -28.243 -18.789 1.00 26.33  ? 20  SER A CA   1 
ATOM   163  C C    . SER A 1 33  ? 8.709   -26.775 -19.136 1.00 24.39  ? 20  SER A C    1 
ATOM   164  O O    . SER A 1 33  ? 7.736   -26.465 -19.806 1.00 23.57  ? 20  SER A O    1 
ATOM   165  C CB   . SER A 1 33  ? 9.952   -28.913 -19.668 1.00 25.93  ? 20  SER A CB   1 
ATOM   166  O OG   . SER A 1 33  ? 9.631   -28.810 -21.056 1.00 24.66  ? 20  SER A OG   1 
ATOM   167  N N    . GLY A 1 34  ? 9.523   -25.884 -18.563 1.00 25.47  ? 21  GLY A N    1 
ATOM   168  C CA   . GLY A 1 34  ? 9.312   -24.450 -18.666 1.00 26.53  ? 21  GLY A CA   1 
ATOM   169  C C    . GLY A 1 34  ? 7.936   -24.049 -18.119 1.00 29.30  ? 21  GLY A C    1 
ATOM   170  O O    . GLY A 1 34  ? 7.322   -23.154 -18.678 1.00 31.92  ? 21  GLY A O    1 
ATOM   171  N N    . GLY A 1 35  ? 7.528   -24.663 -16.988 1.00 28.33  ? 22  GLY A N    1 
ATOM   172  C CA   . GLY A 1 35  ? 6.204   -24.571 -16.394 1.00 26.22  ? 22  GLY A CA   1 
ATOM   173  C C    . GLY A 1 35  ? 5.925   -23.312 -15.572 1.00 28.77  ? 22  GLY A C    1 
ATOM   174  O O    . GLY A 1 35  ? 4.791   -23.094 -15.187 1.00 28.51  ? 22  GLY A O    1 
ATOM   175  N N    . ALA A 1 36  ? 6.941   -22.507 -15.258 1.00 27.22  ? 23  ALA A N    1 
ATOM   176  C CA   . ALA A 1 36  ? 6.753   -21.484 -14.243 1.00 27.37  ? 23  ALA A CA   1 
ATOM   177  C C    . ALA A 1 36  ? 6.273   -20.157 -14.830 1.00 28.87  ? 23  ALA A C    1 
ATOM   178  O O    . ALA A 1 36  ? 5.781   -19.316 -14.085 1.00 32.89  ? 23  ALA A O    1 
ATOM   179  C CB   . ALA A 1 36  ? 7.967   -21.287 -13.339 1.00 26.52  ? 23  ALA A CB   1 
ATOM   180  N N    . SER A 1 37  ? 6.405   -19.967 -16.139 1.00 27.46  ? 24  SER A N    1 
ATOM   181  C CA   . SER A 1 37  ? 5.934   -18.702 -16.692 1.00 35.06  ? 24  SER A CA   1 
ATOM   182  C C    . SER A 1 37  ? 5.322   -18.932 -18.068 1.00 30.50  ? 24  SER A C    1 
ATOM   183  O O    . SER A 1 37  ? 5.423   -20.035 -18.591 1.00 28.22  ? 24  SER A O    1 
ATOM   184  C CB   . SER A 1 37  ? 7.005   -17.619 -16.704 1.00 33.94  ? 24  SER A CB   1 
ATOM   185  O OG   . SER A 1 37  ? 7.979   -17.942 -17.683 1.00 40.59  ? 24  SER A OG   1 
ATOM   186  N N    . GLY A 1 38  ? 4.661   -17.882 -18.599 1.00 36.39  ? 25  GLY A N    1 
ATOM   187  C CA   . GLY A 1 38  ? 4.139   -17.830 -19.960 1.00 34.39  ? 25  GLY A CA   1 
ATOM   188  C C    . GLY A 1 38  ? 3.246   -19.031 -20.276 1.00 28.53  ? 25  GLY A C    1 
ATOM   189  O O    . GLY A 1 38  ? 2.353   -19.377 -19.492 1.00 31.07  ? 25  GLY A O    1 
ATOM   190  N N    . ILE A 1 39  ? 3.500   -19.650 -21.436 1.00 26.57  ? 26  ILE A N    1 
ATOM   191  C CA   . ILE A 1 39  ? 2.635   -20.707 -21.925 1.00 27.70  ? 26  ILE A CA   1 
ATOM   192  C C    . ILE A 1 39  ? 2.652   -21.901 -20.968 1.00 25.59  ? 26  ILE A C    1 
ATOM   193  O O    . ILE A 1 39  ? 1.595   -22.438 -20.628 1.00 26.51  ? 26  ILE A O    1 
ATOM   194  C CB   . ILE A 1 39  ? 2.957   -21.077 -23.382 1.00 28.69  ? 26  ILE A CB   1 
ATOM   195  C CG1  . ILE A 1 39  ? 2.774   -19.859 -24.292 1.00 29.19  ? 26  ILE A CG1  1 
ATOM   196  C CG2  . ILE A 1 39  ? 2.085   -22.260 -23.839 1.00 27.82  ? 26  ILE A CG2  1 
ATOM   197  C CD1  . ILE A 1 39  ? 3.132   -20.117 -25.749 1.00 30.39  ? 26  ILE A CD1  1 
ATOM   198  N N    . GLY A 1 40  ? 3.840   -22.233 -20.450 1.00 23.99  ? 27  GLY A N    1 
ATOM   199  C CA   . GLY A 1 40  ? 4.007   -23.349 -19.521 1.00 23.32  ? 27  GLY A CA   1 
ATOM   200  C C    . GLY A 1 40  ? 3.184   -23.162 -18.240 1.00 25.76  ? 27  GLY A C    1 
ATOM   201  O O    . GLY A 1 40  ? 2.587   -24.103 -17.714 1.00 23.20  ? 27  GLY A O    1 
ATOM   202  N N    . ARG A 1 41  ? 3.142   -21.914 -17.749 1.00 23.75  ? 28  ARG A N    1 
ATOM   203  C CA   . ARG A 1 41  ? 2.389   -21.603 -16.548 1.00 21.36  ? 28  ARG A CA   1 
ATOM   204  C C    . ARG A 1 41  ? 0.905   -21.820 -16.829 1.00 22.39  ? 28  ARG A C    1 
ATOM   205  O O    . ARG A 1 41  ? 0.180   -22.398 -15.999 1.00 25.62  ? 28  ARG A O    1 
ATOM   206  C CB   . ARG A 1 41  ? 2.673   -20.172 -16.069 1.00 21.23  ? 28  ARG A CB   1 
ATOM   207  C CG   . ARG A 1 41  ? 1.757   -19.776 -14.921 1.00 28.94  ? 28  ARG A CG   1 
ATOM   208  C CD   . ARG A 1 41  ? 2.104   -18.348 -14.414 1.00 27.62  ? 28  ARG A CD   1 
ATOM   209  N NE   . ARG A 1 41  ? 0.965   -17.964 -13.573 1.00 33.41  ? 28  ARG A NE   1 
ATOM   210  C CZ   . ARG A 1 41  ? 0.982   -17.002 -12.654 1.00 40.87  ? 28  ARG A CZ   1 
ATOM   211  N NH1  . ARG A 1 41  ? 2.076   -16.283 -12.479 1.00 37.75  ? 28  ARG A NH1  1 
ATOM   212  N NH2  . ARG A 1 41  ? -0.084  -16.755 -11.907 1.00 34.64  ? 28  ARG A NH2  1 
ATOM   213  N N    . ALA A 1 42  ? 0.465   -21.405 -18.021 1.00 24.77  ? 29  ALA A N    1 
ATOM   214  C CA   . ALA A 1 42  ? -0.923  -21.588 -18.401 1.00 25.46  ? 29  ALA A CA   1 
ATOM   215  C C    . ALA A 1 42  ? -1.308  -23.071 -18.451 1.00 25.91  ? 29  ALA A C    1 
ATOM   216  O O    . ALA A 1 42  ? -2.390  -23.455 -18.010 1.00 25.68  ? 29  ALA A O    1 
ATOM   217  C CB   . ALA A 1 42  ? -1.224  -20.870 -19.683 1.00 23.98  ? 29  ALA A CB   1 
ATOM   218  N N    . PHE A 1 43  ? -0.415  -23.899 -18.992 1.00 28.59  ? 30  PHE A N    1 
ATOM   219  C CA   . PHE A 1 43  ? -0.655  -25.330 -18.989 1.00 26.99  ? 30  PHE A CA   1 
ATOM   220  C C    . PHE A 1 43  ? -0.845  -25.791 -17.556 1.00 26.18  ? 30  PHE A C    1 
ATOM   221  O O    . PHE A 1 43  ? -1.775  -26.537 -17.279 1.00 24.41  ? 30  PHE A O    1 
ATOM   222  C CB   . PHE A 1 43  ? 0.494   -26.142 -19.609 1.00 27.56  ? 30  PHE A CB   1 
ATOM   223  C CG   . PHE A 1 43  ? 0.732   -25.890 -21.090 1.00 27.12  ? 30  PHE A CG   1 
ATOM   224  C CD1  . PHE A 1 43  ? -0.333  -25.647 -21.960 1.00 29.74  ? 30  PHE A CD1  1 
ATOM   225  C CD2  . PHE A 1 43  ? 2.012   -25.926 -21.623 1.00 30.98  ? 30  PHE A CD2  1 
ATOM   226  C CE1  . PHE A 1 43  ? -0.112  -25.428 -23.328 1.00 34.05  ? 30  PHE A CE1  1 
ATOM   227  C CE2  . PHE A 1 43  ? 2.240   -25.724 -22.986 1.00 36.05  ? 30  PHE A CE2  1 
ATOM   228  C CZ   . PHE A 1 43  ? 1.171   -25.471 -23.842 1.00 36.20  ? 30  PHE A CZ   1 
ATOM   229  N N    . VAL A 1 44  ? 0.035   -25.335 -16.649 1.00 27.34  ? 31  VAL A N    1 
ATOM   230  C CA   . VAL A 1 44  ? 0.052   -25.856 -15.290 1.00 25.44  ? 31  VAL A CA   1 
ATOM   231  C C    . VAL A 1 44  ? -1.274  -25.516 -14.608 1.00 25.60  ? 31  VAL A C    1 
ATOM   232  O O    . VAL A 1 44  ? -1.929  -26.377 -14.023 1.00 26.40  ? 31  VAL A O    1 
ATOM   233  C CB   . VAL A 1 44  ? 1.277   -25.358 -14.490 1.00 28.30  ? 31  VAL A CB   1 
ATOM   234  C CG1  . VAL A 1 44  ? 1.173   -25.677 -13.004 1.00 32.75  ? 31  VAL A CG1  1 
ATOM   235  C CG2  . VAL A 1 44  ? 2.604   -25.861 -15.081 1.00 23.88  ? 31  VAL A CG2  1 
ATOM   236  N N    . GLU A 1 45  ? -1.704  -24.264 -14.759 1.00 26.46  ? 32  GLU A N    1 
ATOM   237  C CA   . GLU A 1 45  ? -2.972  -23.801 -14.204 1.00 26.07  ? 32  GLU A CA   1 
ATOM   238  C C    . GLU A 1 45  ? -4.149  -24.596 -14.769 1.00 30.48  ? 32  GLU A C    1 
ATOM   239  O O    . GLU A 1 45  ? -5.025  -25.042 -13.995 1.00 31.16  ? 32  GLU A O    1 
ATOM   240  C CB   . GLU A 1 45  ? -3.167  -22.326 -14.506 1.00 24.20  ? 32  GLU A CB   1 
ATOM   241  C CG   . GLU A 1 45  ? -2.195  -21.420 -13.740 1.00 24.59  ? 32  GLU A CG   1 
ATOM   242  C CD   . GLU A 1 45  ? -2.147  -20.014 -14.343 1.00 28.98  ? 32  GLU A CD   1 
ATOM   243  O OE1  . GLU A 1 45  ? -2.625  -19.863 -15.482 1.00 30.99  ? 32  GLU A OE1  1 
ATOM   244  O OE2  . GLU A 1 45  ? -1.645  -19.070 -13.710 1.00 29.36  ? 32  GLU A OE2  1 
ATOM   245  N N    . ALA A 1 46  ? -4.147  -24.783 -16.110 1.00 26.88  ? 33  ALA A N    1 
ATOM   246  C CA   . ALA A 1 46  ? -5.302  -25.370 -16.766 1.00 27.62  ? 33  ALA A CA   1 
ATOM   247  C C    . ALA A 1 46  ? -5.480  -26.818 -16.297 1.00 26.92  ? 33  ALA A C    1 
ATOM   248  O O    . ALA A 1 46  ? -6.612  -27.231 -16.043 1.00 28.63  ? 33  ALA A O    1 
ATOM   249  C CB   . ALA A 1 46  ? -5.182  -25.255 -18.278 1.00 27.35  ? 33  ALA A CB   1 
ATOM   250  N N    . PHE A 1 47  ? -4.378  -27.574 -16.147 1.00 23.60  ? 34  PHE A N    1 
ATOM   251  C CA   . PHE A 1 47  ? -4.529  -28.988 -15.816 1.00 26.66  ? 34  PHE A CA   1 
ATOM   252  C C    . PHE A 1 47  ? -4.867  -29.173 -14.340 1.00 28.50  ? 34  PHE A C    1 
ATOM   253  O O    . PHE A 1 47  ? -5.577  -30.115 -13.938 1.00 29.64  ? 34  PHE A O    1 
ATOM   254  C CB   . PHE A 1 47  ? -3.229  -29.727 -16.131 1.00 26.49  ? 34  PHE A CB   1 
ATOM   255  C CG   . PHE A 1 47  ? -3.108  -30.139 -17.590 1.00 30.70  ? 34  PHE A CG   1 
ATOM   256  C CD1  . PHE A 1 47  ? -3.615  -31.361 -18.030 1.00 31.83  ? 34  PHE A CD1  1 
ATOM   257  C CD2  . PHE A 1 47  ? -2.506  -29.304 -18.526 1.00 26.10  ? 34  PHE A CD2  1 
ATOM   258  C CE1  . PHE A 1 47  ? -3.463  -31.756 -19.361 1.00 29.14  ? 34  PHE A CE1  1 
ATOM   259  C CE2  . PHE A 1 47  ? -2.392  -29.681 -19.873 1.00 26.47  ? 34  PHE A CE2  1 
ATOM   260  C CZ   . PHE A 1 47  ? -2.880  -30.916 -20.276 1.00 28.41  ? 34  PHE A CZ   1 
ATOM   261  N N    . VAL A 1 48  ? -4.302  -28.288 -13.536 1.00 28.45  ? 35  VAL A N    1 
ATOM   262  C CA   . VAL A 1 48  ? -4.605  -28.238 -12.121 1.00 32.80  ? 35  VAL A CA   1 
ATOM   263  C C    . VAL A 1 48  ? -6.115  -28.028 -11.961 1.00 35.17  ? 35  VAL A C    1 
ATOM   264  O O    . VAL A 1 48  ? -6.777  -28.791 -11.223 1.00 31.69  ? 35  VAL A O    1 
ATOM   265  C CB   . VAL A 1 48  ? -3.726  -27.267 -11.308 1.00 31.39  ? 35  VAL A CB   1 
ATOM   266  C CG1  . VAL A 1 48  ? -4.322  -26.911 -9.932  1.00 30.19  ? 35  VAL A CG1  1 
ATOM   267  C CG2  . VAL A 1 48  ? -2.311  -27.815 -11.136 1.00 26.85  ? 35  VAL A CG2  1 
ATOM   268  N N    . ALA A 1 49  ? -6.654  -27.087 -12.754 1.00 32.60  ? 36  ALA A N    1 
ATOM   269  C CA   . ALA A 1 49  ? -8.084  -26.770 -12.707 1.00 31.47  ? 36  ALA A CA   1 
ATOM   270  C C    . ALA A 1 49  ? -8.963  -27.939 -13.146 1.00 32.28  ? 36  ALA A C    1 
ATOM   271  O O    . ALA A 1 49  ? -10.165 -27.911 -12.889 1.00 31.93  ? 36  ALA A O    1 
ATOM   272  C CB   . ALA A 1 49  ? -8.446  -25.488 -13.447 1.00 32.05  ? 36  ALA A CB   1 
ATOM   273  N N    . GLN A 1 50  ? -8.372  -28.985 -13.749 1.00 29.31  ? 37  GLN A N    1 
ATOM   274  C CA   . GLN A 1 50  ? -9.118  -30.155 -14.192 1.00 27.66  ? 37  GLN A CA   1 
ATOM   275  C C    . GLN A 1 50  ? -8.927  -31.306 -13.201 1.00 31.74  ? 37  GLN A C    1 
ATOM   276  O O    . GLN A 1 50  ? -9.346  -32.455 -13.452 1.00 31.95  ? 37  GLN A O    1 
ATOM   277  C CB   . GLN A 1 50  ? -8.611  -30.650 -15.554 1.00 31.91  ? 37  GLN A CB   1 
ATOM   278  C CG   . GLN A 1 50  ? -8.887  -29.714 -16.729 1.00 28.92  ? 37  GLN A CG   1 
ATOM   279  C CD   . GLN A 1 50  ? -10.335 -29.612 -17.141 1.00 33.79  ? 37  GLN A CD   1 
ATOM   280  O OE1  . GLN A 1 50  ? -11.071 -30.612 -17.143 1.00 32.35  ? 37  GLN A OE1  1 
ATOM   281  N NE2  . GLN A 1 50  ? -10.738 -28.395 -17.512 1.00 29.99  ? 37  GLN A NE2  1 
ATOM   282  N N    . GLY A 1 51  ? -8.217  -31.019 -12.098 1.00 36.17  ? 38  GLY A N    1 
ATOM   283  C CA   . GLY A 1 51  ? -8.001  -32.015 -11.049 1.00 29.01  ? 38  GLY A CA   1 
ATOM   284  C C    . GLY A 1 51  ? -6.883  -32.994 -11.393 1.00 33.99  ? 38  GLY A C    1 
ATOM   285  O O    . GLY A 1 51  ? -6.791  -34.080 -10.806 1.00 31.78  ? 38  GLY A O    1 
ATOM   286  N N    . SER A 1 52  ? -6.034  -32.624 -12.368 1.00 33.15  ? 39  SER A N    1 
ATOM   287  C CA   . SER A 1 52  ? -4.801  -33.373 -12.587 1.00 29.13  ? 39  SER A CA   1 
ATOM   288  C C    . SER A 1 52  ? -3.795  -33.114 -11.463 1.00 29.80  ? 39  SER A C    1 
ATOM   289  O O    . SER A 1 52  ? -3.861  -32.073 -10.797 1.00 26.99  ? 39  SER A O    1 
ATOM   290  C CB   . SER A 1 52  ? -4.170  -33.009 -13.919 1.00 28.15  ? 39  SER A CB   1 
ATOM   291  O OG   . SER A 1 52  ? -5.123  -33.087 -14.958 1.00 33.63  ? 39  SER A OG   1 
ATOM   292  N N    . ARG A 1 53  ? -2.859  -34.071 -11.302 1.00 29.31  ? 40  ARG A N    1 
ATOM   293  C CA   . ARG A 1 53  ? -1.635  -33.912 -10.524 1.00 31.47  ? 40  ARG A CA   1 
ATOM   294  C C    . ARG A 1 53  ? -0.493  -33.451 -11.438 1.00 28.73  ? 40  ARG A C    1 
ATOM   295  O O    . ARG A 1 53  ? 0.024   -34.248 -12.237 1.00 26.45  ? 40  ARG A O    1 
ATOM   296  C CB   . ARG A 1 53  ? -1.300  -35.228 -9.814  1.00 27.32  ? 40  ARG A CB   1 
ATOM   297  C CG   . ARG A 1 53  ? -2.288  -35.616 -8.719  1.00 32.93  ? 40  ARG A CG   1 
ATOM   298  C CD   . ARG A 1 53  ? -1.960  -36.971 -8.077  1.00 34.85  ? 40  ARG A CD   1 
ATOM   299  N NE   . ARG A 1 53  ? -2.271  -38.038 -9.026  1.00 38.24  ? 40  ARG A NE   1 
ATOM   300  C CZ   . ARG A 1 53  ? -1.846  -39.307 -8.976  1.00 47.40  ? 40  ARG A CZ   1 
ATOM   301  N NH1  . ARG A 1 53  ? -0.912  -39.661 -8.105  1.00 47.97  ? 40  ARG A NH1  1 
ATOM   302  N NH2  . ARG A 1 53  ? -2.313  -40.207 -9.840  1.00 40.30  ? 40  ARG A NH2  1 
ATOM   303  N N    . VAL A 1 54  ? -0.089  -32.174 -11.286 1.00 27.61  ? 41  VAL A N    1 
ATOM   304  C CA   . VAL A 1 54  ? 0.782   -31.511 -12.249 1.00 25.48  ? 41  VAL A CA   1 
ATOM   305  C C    . VAL A 1 54  ? 2.146   -31.209 -11.618 1.00 32.19  ? 41  VAL A C    1 
ATOM   306  O O    . VAL A 1 54  ? 2.238   -30.453 -10.649 1.00 30.87  ? 41  VAL A O    1 
ATOM   307  C CB   . VAL A 1 54  ? 0.066   -30.238 -12.721 1.00 26.98  ? 41  VAL A CB   1 
ATOM   308  C CG1  . VAL A 1 54  ? 0.863   -29.422 -13.736 1.00 24.30  ? 41  VAL A CG1  1 
ATOM   309  C CG2  . VAL A 1 54  ? -1.334  -30.564 -13.266 1.00 29.69  ? 41  VAL A CG2  1 
ATOM   310  N N    . ALA A 1 55  ? 3.199   -31.840 -12.171 1.00 28.75  ? 42  ALA A N    1 
ATOM   311  C CA   . ALA A 1 55  ? 4.583   -31.525 -11.889 1.00 29.91  ? 42  ALA A CA   1 
ATOM   312  C C    . ALA A 1 55  ? 5.094   -30.579 -12.974 1.00 25.43  ? 42  ALA A C    1 
ATOM   313  O O    . ALA A 1 55  ? 4.742   -30.757 -14.133 1.00 29.66  ? 42  ALA A O    1 
ATOM   314  C CB   . ALA A 1 55  ? 5.401   -32.802 -11.863 1.00 28.12  ? 42  ALA A CB   1 
ATOM   315  N N    . PHE A 1 56  ? 5.923   -29.603 -12.596 1.00 22.28  ? 43  PHE A N    1 
ATOM   316  C CA   . PHE A 1 56  ? 6.530   -28.742 -13.592 1.00 24.81  ? 43  PHE A CA   1 
ATOM   317  C C    . PHE A 1 56  ? 7.982   -28.452 -13.242 1.00 26.83  ? 43  PHE A C    1 
ATOM   318  O O    . PHE A 1 56  ? 8.372   -28.412 -12.078 1.00 30.23  ? 43  PHE A O    1 
ATOM   319  C CB   . PHE A 1 56  ? 5.662   -27.510 -13.886 1.00 25.56  ? 43  PHE A CB   1 
ATOM   320  C CG   . PHE A 1 56  ? 5.492   -26.578 -12.688 1.00 24.40  ? 43  PHE A CG   1 
ATOM   321  C CD1  . PHE A 1 56  ? 4.720   -26.954 -11.601 1.00 25.35  ? 43  PHE A CD1  1 
ATOM   322  C CD2  . PHE A 1 56  ? 6.082   -25.314 -12.676 1.00 27.29  ? 43  PHE A CD2  1 
ATOM   323  C CE1  . PHE A 1 56  ? 4.589   -26.113 -10.504 1.00 27.29  ? 43  PHE A CE1  1 
ATOM   324  C CE2  . PHE A 1 56  ? 5.933   -24.451 -11.593 1.00 27.32  ? 43  PHE A CE2  1 
ATOM   325  C CZ   . PHE A 1 56  ? 5.169   -24.844 -10.508 1.00 25.28  ? 43  PHE A CZ   1 
ATOM   326  N N    . LEU A 1 57  ? 8.769   -28.246 -14.298 1.00 26.45  ? 44  LEU A N    1 
ATOM   327  C CA   . LEU A 1 57  ? 10.209  -28.016 -14.285 1.00 30.39  ? 44  LEU A CA   1 
ATOM   328  C C    . LEU A 1 57  ? 10.426  -26.584 -14.734 1.00 26.87  ? 44  LEU A C    1 
ATOM   329  O O    . LEU A 1 57  ? 9.737   -26.105 -15.634 1.00 32.74  ? 44  LEU A O    1 
ATOM   330  C CB   . LEU A 1 57  ? 10.861  -28.973 -15.285 1.00 28.52  ? 44  LEU A CB   1 
ATOM   331  C CG   . LEU A 1 57  ? 11.173  -30.399 -14.823 1.00 32.58  ? 44  LEU A CG   1 
ATOM   332  C CD1  . LEU A 1 57  ? 10.169  -31.137 -13.992 1.00 37.33  ? 44  LEU A CD1  1 
ATOM   333  C CD2  . LEU A 1 57  ? 11.522  -31.168 -16.078 1.00 28.38  ? 44  LEU A CD2  1 
ATOM   334  N N    . ASP A 1 58  ? 11.347  -25.889 -14.070 1.00 27.70  ? 45  ASP A N    1 
ATOM   335  C CA   . ASP A 1 58  ? 11.741  -24.583 -14.570 1.00 31.22  ? 45  ASP A CA   1 
ATOM   336  C C    . ASP A 1 58  ? 13.071  -24.192 -13.946 1.00 31.81  ? 45  ASP A C    1 
ATOM   337  O O    . ASP A 1 58  ? 13.446  -24.704 -12.896 1.00 28.99  ? 45  ASP A O    1 
ATOM   338  C CB   . ASP A 1 58  ? 10.681  -23.537 -14.306 1.00 34.94  ? 45  ASP A CB   1 
ATOM   339  C CG   . ASP A 1 58  ? 10.707  -22.339 -15.242 1.00 45.77  ? 45  ASP A CG   1 
ATOM   340  O OD1  . ASP A 1 58  ? 11.592  -21.447 -15.057 1.00 47.49  ? 45  ASP A OD1  1 
ATOM   341  O OD2  . ASP A 1 58  ? 9.837   -22.314 -16.144 1.00 41.91  ? 45  ASP A OD2  1 
ATOM   342  N N    . LEU A 1 59  ? 13.797  -23.319 -14.656 1.00 31.88  ? 46  LEU A N    1 
ATOM   343  C CA   . LEU A 1 59  ? 15.079  -22.823 -14.199 1.00 33.53  ? 46  LEU A CA   1 
ATOM   344  C C    . LEU A 1 59  ? 14.841  -21.807 -13.070 1.00 38.16  ? 46  LEU A C    1 
ATOM   345  O O    . LEU A 1 59  ? 15.647  -21.693 -12.150 1.00 44.69  ? 46  LEU A O    1 
ATOM   346  C CB   . LEU A 1 59  ? 15.684  -22.173 -15.453 1.00 38.91  ? 46  LEU A CB   1 
ATOM   347  C CG   . LEU A 1 59  ? 17.210  -21.969 -15.488 1.00 51.34  ? 46  LEU A CG   1 
ATOM   348  C CD1  . LEU A 1 59  ? 17.613  -21.204 -16.748 1.00 43.29  ? 46  LEU A CD1  1 
ATOM   349  C CD2  . LEU A 1 59  ? 17.845  -21.294 -14.284 1.00 47.48  ? 46  LEU A CD2  1 
ATOM   350  N N    . ASP A 1 60  ? 13.731  -21.064 -13.123 1.00 30.60  ? 47  ASP A N    1 
ATOM   351  C CA   . ASP A 1 60  ? 13.505  -19.967 -12.178 1.00 33.07  ? 47  ASP A CA   1 
ATOM   352  C C    . ASP A 1 60  ? 12.872  -20.488 -10.891 1.00 30.66  ? 47  ASP A C    1 
ATOM   353  O O    . ASP A 1 60  ? 11.666  -20.689 -10.848 1.00 31.72  ? 47  ASP A O    1 
ATOM   354  C CB   . ASP A 1 60  ? 12.721  -18.836 -12.830 1.00 30.05  ? 47  ASP A CB   1 
ATOM   355  C CG   . ASP A 1 60  ? 12.453  -17.618 -11.951 1.00 33.71  ? 47  ASP A CG   1 
ATOM   356  O OD1  . ASP A 1 60  ? 12.744  -17.668 -10.735 1.00 28.82  ? 47  ASP A OD1  1 
ATOM   357  O OD2  . ASP A 1 60  ? 12.006  -16.598 -12.507 1.00 34.85  ? 47  ASP A OD2  1 
ATOM   358  N N    . ALA A 1 61  ? 13.696  -20.700 -9.846  1.00 30.60  ? 48  ALA A N    1 
ATOM   359  C CA   . ALA A 1 61  ? 13.293  -21.376 -8.614  1.00 32.93  ? 48  ALA A CA   1 
ATOM   360  C C    . ALA A 1 61  ? 12.216  -20.591 -7.866  1.00 38.13  ? 48  ALA A C    1 
ATOM   361  O O    . ALA A 1 61  ? 11.270  -21.188 -7.360  1.00 40.35  ? 48  ALA A O    1 
ATOM   362  C CB   . ALA A 1 61  ? 14.502  -21.640 -7.692  1.00 31.65  ? 48  ALA A CB   1 
ATOM   363  N N    . GLU A 1 62  ? 12.368  -19.257 -7.789  1.00 36.33  ? 49  GLU A N    1 
ATOM   364  C CA   . GLU A 1 62  ? 11.444  -18.412 -7.044  1.00 39.12  ? 49  GLU A CA   1 
ATOM   365  C C    . GLU A 1 62  ? 10.094  -18.334 -7.766  1.00 35.04  ? 49  GLU A C    1 
ATOM   366  O O    . GLU A 1 62  ? 9.046   -18.456 -7.124  1.00 37.55  ? 49  GLU A O    1 
ATOM   367  C CB   . GLU A 1 62  ? 12.029  -17.033 -6.748  1.00 46.89  ? 49  GLU A CB   1 
ATOM   368  C CG   . GLU A 1 62  ? 11.571  -16.488 -5.398  1.00 64.21  ? 49  GLU A CG   1 
ATOM   369  C CD   . GLU A 1 62  ? 12.450  -15.347 -4.905  1.00 81.60  ? 49  GLU A CD   1 
ATOM   370  O OE1  . GLU A 1 62  ? 12.523  -14.316 -5.612  1.00 79.85  ? 49  GLU A OE1  1 
ATOM   371  O OE2  . GLU A 1 62  ? 13.071  -15.491 -3.822  1.00 92.61  ? 49  GLU A OE2  1 
ATOM   372  N N    . ALA A 1 63  ? 10.118  -18.180 -9.091  1.00 31.75  ? 50  ALA A N    1 
ATOM   373  C CA   . ALA A 1 63  ? 8.861   -18.205 -9.828  1.00 35.51  ? 50  ALA A CA   1 
ATOM   374  C C    . ALA A 1 63  ? 8.209   -19.583 -9.659  1.00 31.18  ? 50  ALA A C    1 
ATOM   375  O O    . ALA A 1 63  ? 7.020   -19.672 -9.396  1.00 28.09  ? 50  ALA A O    1 
ATOM   376  C CB   . ALA A 1 63  ? 9.040   -17.811 -11.293 1.00 31.17  ? 50  ALA A CB   1 
ATOM   377  N N    . GLY A 1 64  ? 9.008   -20.651 -9.752  1.00 33.53  ? 51  GLY A N    1 
ATOM   378  C CA   . GLY A 1 64  ? 8.466   -21.993 -9.663  1.00 28.53  ? 51  GLY A CA   1 
ATOM   379  C C    . GLY A 1 64  ? 7.767   -22.247 -8.333  1.00 29.66  ? 51  GLY A C    1 
ATOM   380  O O    . GLY A 1 64  ? 6.636   -22.724 -8.308  1.00 29.36  ? 51  GLY A O    1 
ATOM   381  N N    . GLN A 1 65  ? 8.447   -21.911 -7.229  1.00 30.20  ? 52  GLN A N    1 
ATOM   382  C CA   . GLN A 1 65  ? 7.958   -22.212 -5.897  1.00 32.74  ? 52  GLN A CA   1 
ATOM   383  C C    . GLN A 1 65  ? 6.737   -21.352 -5.596  1.00 28.40  ? 52  GLN A C    1 
ATOM   384  O O    . GLN A 1 65  ? 5.801   -21.842 -5.004  1.00 26.05  ? 52  GLN A O    1 
ATOM   385  C CB   . GLN A 1 65  ? 8.980   -21.926 -4.791  1.00 40.38  ? 52  GLN A CB   1 
ATOM   386  C CG   . GLN A 1 65  ? 10.274  -22.730 -4.840  1.00 47.27  ? 52  GLN A CG   1 
ATOM   387  C CD   . GLN A 1 65  ? 11.413  -21.969 -4.184  1.00 52.81  ? 52  GLN A CD   1 
ATOM   388  O OE1  . GLN A 1 65  ? 11.216  -20.916 -3.559  1.00 55.27  ? 52  GLN A OE1  1 
ATOM   389  N NE2  . GLN A 1 65  ? 12.629  -22.481 -4.328  1.00 46.31  ? 52  GLN A NE2  1 
ATOM   390  N N    . GLY A 1 66  ? 6.726   -20.088 -6.026  1.00 29.86  ? 53  GLY A N    1 
ATOM   391  C CA   . GLY A 1 66  ? 5.549   -19.258 -5.802  1.00 29.51  ? 53  GLY A CA   1 
ATOM   392  C C    . GLY A 1 66  ? 4.316   -19.789 -6.534  1.00 34.57  ? 53  GLY A C    1 
ATOM   393  O O    . GLY A 1 66  ? 3.185   -19.697 -6.041  1.00 31.58  ? 53  GLY A O    1 
ATOM   394  N N    . LEU A 1 67  ? 4.521   -20.318 -7.743  1.00 31.33  ? 54  LEU A N    1 
ATOM   395  C CA   . LEU A 1 67  ? 3.381   -20.784 -8.518  1.00 32.44  ? 54  LEU A CA   1 
ATOM   396  C C    . LEU A 1 67  ? 2.840   -22.065 -7.873  1.00 33.79  ? 54  LEU A C    1 
ATOM   397  O O    . LEU A 1 67  ? 1.629   -22.199 -7.695  1.00 31.28  ? 54  LEU A O    1 
ATOM   398  C CB   . LEU A 1 67  ? 3.752   -20.985 -9.998  1.00 37.70  ? 54  LEU A CB   1 
ATOM   399  C CG   . LEU A 1 67  ? 2.736   -21.719 -10.886 1.00 35.59  ? 54  LEU A CG   1 
ATOM   400  C CD1  . LEU A 1 67  ? 1.448   -20.901 -11.062 1.00 32.35  ? 54  LEU A CD1  1 
ATOM   401  C CD2  . LEU A 1 67  ? 3.284   -22.119 -12.248 1.00 34.06  ? 54  LEU A CD2  1 
ATOM   402  N N    . ALA A 1 68  ? 3.731   -22.966 -7.445  1.00 30.25  ? 55  ALA A N    1 
ATOM   403  C CA   . ALA A 1 68  ? 3.297   -24.197 -6.804  1.00 33.15  ? 55  ALA A CA   1 
ATOM   404  C C    . ALA A 1 68  ? 2.605   -23.891 -5.476  1.00 36.75  ? 55  ALA A C    1 
ATOM   405  O O    . ALA A 1 68  ? 1.657   -24.583 -5.076  1.00 33.42  ? 55  ALA A O    1 
ATOM   406  C CB   . ALA A 1 68  ? 4.486   -25.118 -6.570  1.00 31.18  ? 55  ALA A CB   1 
ATOM   407  N N    . HIS A 1 69  ? 3.130   -22.896 -4.754  1.00 34.28  ? 56  HIS A N    1 
ATOM   408  C CA   . HIS A 1 69  ? 2.467   -22.463 -3.527  1.00 35.32  ? 56  HIS A CA   1 
ATOM   409  C C    . HIS A 1 69  ? 1.064   -21.922 -3.837  1.00 32.87  ? 56  HIS A C    1 
ATOM   410  O O    . HIS A 1 69  ? 0.096   -22.297 -3.183  1.00 37.96  ? 56  HIS A O    1 
ATOM   411  C CB   . HIS A 1 69  ? 3.339   -21.488 -2.725  1.00 28.45  ? 56  HIS A CB   1 
ATOM   412  C CG   . HIS A 1 69  ? 2.719   -21.195 -1.411  1.00 33.49  ? 56  HIS A CG   1 
ATOM   413  N ND1  . HIS A 1 69  ? 2.034   -20.020 -1.147  1.00 34.30  ? 56  HIS A ND1  1 
ATOM   414  C CD2  . HIS A 1 69  ? 2.636   -21.953 -0.289  1.00 32.57  ? 56  HIS A CD2  1 
ATOM   415  C CE1  . HIS A 1 69  ? 1.611   -20.048 0.107   1.00 32.82  ? 56  HIS A CE1  1 
ATOM   416  N NE2  . HIS A 1 69  ? 1.937   -21.226 0.632   1.00 39.73  ? 56  HIS A NE2  1 
ATOM   417  N N    . ALA A 1 70  ? 0.938   -21.084 -4.869  1.00 31.14  ? 57  ALA A N    1 
ATOM   418  C CA   . ALA A 1 70  ? -0.393  -20.584 -5.237  1.00 38.53  ? 57  ALA A CA   1 
ATOM   419  C C    . ALA A 1 70  ? -1.375  -21.695 -5.652  1.00 38.48  ? 57  ALA A C    1 
ATOM   420  O O    . ALA A 1 70  ? -2.571  -21.566 -5.398  1.00 35.24  ? 57  ALA A O    1 
ATOM   421  C CB   . ALA A 1 70  ? -0.308  -19.453 -6.256  1.00 30.88  ? 57  ALA A CB   1 
ATOM   422  N N    . LEU A 1 71  ? -0.890  -22.800 -6.254  1.00 38.29  ? 58  LEU A N    1 
ATOM   423  C CA   . LEU A 1 71  ? -1.765  -23.827 -6.833  1.00 39.59  ? 58  LEU A CA   1 
ATOM   424  C C    . LEU A 1 71  ? -2.071  -24.937 -5.824  1.00 40.23  ? 58  LEU A C    1 
ATOM   425  O O    . LEU A 1 71  ? -3.074  -25.640 -5.941  1.00 39.54  ? 58  LEU A O    1 
ATOM   426  C CB   . LEU A 1 71  ? -1.248  -24.442 -8.137  1.00 35.53  ? 58  LEU A CB   1 
ATOM   427  C CG   . LEU A 1 71  ? -1.130  -23.506 -9.352  1.00 45.40  ? 58  LEU A CG   1 
ATOM   428  C CD1  . LEU A 1 71  ? -0.992  -24.316 -10.623 1.00 40.51  ? 58  LEU A CD1  1 
ATOM   429  C CD2  . LEU A 1 71  ? -2.252  -22.468 -9.537  1.00 44.95  ? 58  LEU A CD2  1 
ATOM   430  N N    . GLY A 1 72  ? -1.175  -25.153 -4.866  1.00 40.19  ? 59  GLY A N    1 
ATOM   431  C CA   . GLY A 1 72  ? -1.509  -26.119 -3.841  1.00 37.41  ? 59  GLY A CA   1 
ATOM   432  C C    . GLY A 1 72  ? -0.959  -27.495 -4.158  1.00 38.03  ? 59  GLY A C    1 
ATOM   433  O O    . GLY A 1 72  ? -0.100  -27.635 -5.018  1.00 34.77  ? 59  GLY A O    1 
ATOM   434  N N    . ALA A 1 73  ? -1.472  -28.491 -3.430  1.00 34.11  ? 60  ALA A N    1 
ATOM   435  C CA   . ALA A 1 73  ? -0.810  -29.766 -3.209  1.00 40.66  ? 60  ALA A CA   1 
ATOM   436  C C    . ALA A 1 73  ? -0.925  -30.697 -4.410  1.00 37.81  ? 60  ALA A C    1 
ATOM   437  O O    . ALA A 1 73  ? -0.281  -31.735 -4.432  1.00 37.83  ? 60  ALA A O    1 
ATOM   438  C CB   . ALA A 1 73  ? -1.402  -30.421 -1.968  1.00 39.88  ? 60  ALA A CB   1 
ATOM   439  N N    . ASN A 1 74  ? -1.761  -30.347 -5.399  1.00 38.22  ? 61  ASN A N    1 
ATOM   440  C CA   . ASN A 1 74  ? -1.783  -31.111 -6.644  1.00 38.86  ? 61  ASN A CA   1 
ATOM   441  C C    . ASN A 1 74  ? -0.800  -30.533 -7.674  1.00 39.28  ? 61  ASN A C    1 
ATOM   442  O O    . ASN A 1 74  ? -0.831  -30.917 -8.845  1.00 40.09  ? 61  ASN A O    1 
ATOM   443  C CB   . ASN A 1 74  ? -3.181  -31.153 -7.252  1.00 34.96  ? 61  ASN A CB   1 
ATOM   444  C CG   . ASN A 1 74  ? -4.106  -32.135 -6.577  1.00 34.97  ? 61  ASN A CG   1 
ATOM   445  O OD1  . ASN A 1 74  ? -3.677  -32.924 -5.728  1.00 40.22  ? 61  ASN A OD1  1 
ATOM   446  N ND2  . ASN A 1 74  ? -5.354  -32.158 -7.023  1.00 32.39  ? 61  ASN A ND2  1 
ATOM   447  N N    . SER A 1 75  ? 0.035   -29.574 -7.240  1.00 37.83  ? 62  SER A N    1 
ATOM   448  C CA   . SER A 1 75  ? 1.118   -29.019 -8.047  1.00 33.36  ? 62  SER A CA   1 
ATOM   449  C C    . SER A 1 75  ? 2.445   -29.346 -7.371  1.00 34.08  ? 62  SER A C    1 
ATOM   450  O O    . SER A 1 75  ? 2.482   -29.462 -6.144  1.00 30.66  ? 62  SER A O    1 
ATOM   451  C CB   . SER A 1 75  ? 0.936   -27.529 -8.334  1.00 33.20  ? 62  SER A CB   1 
ATOM   452  O OG   . SER A 1 75  ? 1.306   -26.713 -7.238  1.00 37.22  ? 62  SER A OG   1 
ATOM   453  N N    . LEU A 1 76  ? 3.467   -29.674 -8.184  1.00 30.06  ? 63  LEU A N    1 
ATOM   454  C CA   . LEU A 1 76  ? 4.794   -30.022 -7.701  1.00 30.00  ? 63  LEU A CA   1 
ATOM   455  C C    . LEU A 1 76  ? 5.822   -29.309 -8.581  1.00 30.30  ? 63  LEU A C    1 
ATOM   456  O O    . LEU A 1 76  ? 5.875   -29.556 -9.787  1.00 33.03  ? 63  LEU A O    1 
ATOM   457  C CB   . LEU A 1 76  ? 4.968   -31.543 -7.747  1.00 29.26  ? 63  LEU A CB   1 
ATOM   458  C CG   . LEU A 1 76  ? 6.397   -32.053 -7.514  1.00 35.19  ? 63  LEU A CG   1 
ATOM   459  C CD1  . LEU A 1 76  ? 6.848   -31.625 -6.111  1.00 39.41  ? 63  LEU A CD1  1 
ATOM   460  C CD2  . LEU A 1 76  ? 6.466   -33.555 -7.666  1.00 34.35  ? 63  LEU A CD2  1 
ATOM   461  N N    . PHE A 1 77  ? 6.634   -28.430 -7.983  1.00 26.86  ? 64  PHE A N    1 
ATOM   462  C CA   . PHE A 1 77  ? 7.666   -27.728 -8.746  1.00 25.80  ? 64  PHE A CA   1 
ATOM   463  C C    . PHE A 1 77  ? 9.022   -28.386 -8.498  1.00 30.25  ? 64  PHE A C    1 
ATOM   464  O O    . PHE A 1 77  ? 9.420   -28.560 -7.346  1.00 30.56  ? 64  PHE A O    1 
ATOM   465  C CB   . PHE A 1 77  ? 7.771   -26.253 -8.335  1.00 25.85  ? 64  PHE A CB   1 
ATOM   466  C CG   . PHE A 1 77  ? 9.030   -25.595 -8.876  1.00 30.60  ? 64  PHE A CG   1 
ATOM   467  C CD1  . PHE A 1 77  ? 9.211   -25.466 -10.250 1.00 29.75  ? 64  PHE A CD1  1 
ATOM   468  C CD2  . PHE A 1 77  ? 10.004  -25.065 -8.030  1.00 31.18  ? 64  PHE A CD2  1 
ATOM   469  C CE1  . PHE A 1 77  ? 10.347  -24.859 -10.760 1.00 24.55  ? 64  PHE A CE1  1 
ATOM   470  C CE2  . PHE A 1 77  ? 11.154  -24.464 -8.551  1.00 30.19  ? 64  PHE A CE2  1 
ATOM   471  C CZ   . PHE A 1 77  ? 11.303  -24.337 -9.918  1.00 26.29  ? 64  PHE A CZ   1 
ATOM   472  N N    . LEU A 1 78  ? 9.716   -28.764 -9.581  1.00 26.01  ? 65  LEU A N    1 
ATOM   473  C CA   . LEU A 1 78  ? 11.075  -29.264 -9.496  1.00 27.65  ? 65  LEU A CA   1 
ATOM   474  C C    . LEU A 1 78  ? 11.964  -28.274 -10.233 1.00 30.28  ? 65  LEU A C    1 
ATOM   475  O O    . LEU A 1 78  ? 11.786  -28.035 -11.430 1.00 28.79  ? 65  LEU A O    1 
ATOM   476  C CB   . LEU A 1 78  ? 11.255  -30.683 -10.036 1.00 30.34  ? 65  LEU A CB   1 
ATOM   477  C CG   . LEU A 1 78  ? 10.409  -31.755 -9.327  1.00 35.58  ? 65  LEU A CG   1 
ATOM   478  C CD1  . LEU A 1 78  ? 10.851  -33.139 -9.662  1.00 32.67  ? 65  LEU A CD1  1 
ATOM   479  C CD2  . LEU A 1 78  ? 10.454  -31.614 -7.813  1.00 42.95  ? 65  LEU A CD2  1 
ATOM   480  N N    . PRO A 1 79  ? 12.976  -27.704 -9.555  1.00 28.34  ? 66  PRO A N    1 
ATOM   481  C CA   . PRO A 1 79  ? 13.966  -26.889 -10.251 1.00 28.49  ? 66  PRO A CA   1 
ATOM   482  C C    . PRO A 1 79  ? 14.782  -27.751 -11.234 1.00 30.82  ? 66  PRO A C    1 
ATOM   483  O O    . PRO A 1 79  ? 15.115  -28.900 -10.940 1.00 34.94  ? 66  PRO A O    1 
ATOM   484  C CB   . PRO A 1 79  ? 14.758  -26.269 -9.098  1.00 29.00  ? 66  PRO A CB   1 
ATOM   485  C CG   . PRO A 1 79  ? 14.681  -27.393 -8.021  1.00 31.63  ? 66  PRO A CG   1 
ATOM   486  C CD   . PRO A 1 79  ? 13.262  -27.904 -8.117  1.00 30.24  ? 66  PRO A CD   1 
ATOM   487  N N    . CYS A 1 80  ? 15.012  -27.219 -12.437 1.00 29.12  ? 67  CYS A N    1 
ATOM   488  C CA   . CYS A 1 80  ? 15.653  -27.989 -13.482 1.00 33.41  ? 67  CYS A CA   1 
ATOM   489  C C    . CYS A 1 80  ? 16.136  -27.065 -14.599 1.00 35.66  ? 67  CYS A C    1 
ATOM   490  O O    . CYS A 1 80  ? 15.386  -26.229 -15.134 1.00 36.83  ? 67  CYS A O    1 
ATOM   491  C CB   . CYS A 1 80  ? 14.695  -29.020 -14.061 1.00 34.96  ? 67  CYS A CB   1 
ATOM   492  S SG   . CYS A 1 80  ? 15.489  -30.187 -15.195 1.00 33.38  ? 67  CYS A SG   1 
ATOM   493  N N    . ASP A 1 81  ? 17.421  -27.218 -14.914 1.00 31.78  ? 68  ASP A N    1 
ATOM   494  C CA   . ASP A 1 81  ? 17.964  -26.719 -16.164 1.00 30.75  ? 68  ASP A CA   1 
ATOM   495  C C    . ASP A 1 81  ? 17.899  -27.855 -17.191 1.00 34.04  ? 68  ASP A C    1 
ATOM   496  O O    . ASP A 1 81  ? 18.606  -28.850 -17.051 1.00 34.86  ? 68  ASP A O    1 
ATOM   497  C CB   . ASP A 1 81  ? 19.350  -26.141 -15.970 1.00 36.97  ? 68  ASP A CB   1 
ATOM   498  C CG   . ASP A 1 81  ? 20.001  -25.594 -17.232 1.00 42.01  ? 68  ASP A CG   1 
ATOM   499  O OD1  . ASP A 1 81  ? 19.462  -25.830 -18.340 1.00 37.39  ? 68  ASP A OD1  1 
ATOM   500  O OD2  . ASP A 1 81  ? 21.031  -24.921 -17.097 1.00 48.63  ? 68  ASP A OD2  1 
ATOM   501  N N    . VAL A 1 82  ? 17.027  -27.701 -18.205 1.00 28.63  ? 69  VAL A N    1 
ATOM   502  C CA   . VAL A 1 82  ? 16.709  -28.769 -19.149 1.00 33.36  ? 69  VAL A CA   1 
ATOM   503  C C    . VAL A 1 82  ? 17.933  -29.159 -19.997 1.00 38.93  ? 69  VAL A C    1 
ATOM   504  O O    . VAL A 1 82  ? 17.990  -30.266 -20.526 1.00 35.65  ? 69  VAL A O    1 
ATOM   505  C CB   . VAL A 1 82  ? 15.471  -28.466 -20.017 1.00 30.89  ? 69  VAL A CB   1 
ATOM   506  C CG1  . VAL A 1 82  ? 14.195  -28.540 -19.177 1.00 36.28  ? 69  VAL A CG1  1 
ATOM   507  C CG2  . VAL A 1 82  ? 15.593  -27.139 -20.782 1.00 30.44  ? 69  VAL A CG2  1 
ATOM   508  N N    . ARG A 1 83  ? 18.890  -28.224 -20.142 1.00 37.45  ? 70  ARG A N    1 
ATOM   509  C CA   . ARG A 1 83  ? 20.199  -28.532 -20.700 1.00 43.36  ? 70  ARG A CA   1 
ATOM   510  C C    . ARG A 1 83  ? 20.853  -29.672 -19.924 1.00 42.44  ? 70  ARG A C    1 
ATOM   511  O O    . ARG A 1 83  ? 21.616  -30.432 -20.512 1.00 40.05  ? 70  ARG A O    1 
ATOM   512  C CB   . ARG A 1 83  ? 21.145  -27.328 -20.722 1.00 41.24  ? 70  ARG A CB   1 
ATOM   513  C CG   . ARG A 1 83  ? 20.582  -26.235 -21.609 1.00 49.24  ? 70  ARG A CG   1 
ATOM   514  C CD   . ARG A 1 83  ? 20.955  -24.861 -21.119 1.00 57.34  ? 70  ARG A CD   1 
ATOM   515  N NE   . ARG A 1 83  ? 22.403  -24.674 -21.159 1.00 72.83  ? 70  ARG A NE   1 
ATOM   516  C CZ   . ARG A 1 83  ? 23.018  -23.562 -20.789 1.00 73.25  ? 70  ARG A CZ   1 
ATOM   517  N NH1  . ARG A 1 83  ? 24.336  -23.567 -20.693 1.00 74.68  ? 70  ARG A NH1  1 
ATOM   518  N NH2  . ARG A 1 83  ? 22.319  -22.483 -20.470 1.00 64.21  ? 70  ARG A NH2  1 
ATOM   519  N N    . ASP A 1 84  ? 20.594  -29.754 -18.608 1.00 38.24  ? 71  ASP A N    1 
ATOM   520  C CA   . ASP A 1 84  ? 21.238  -30.769 -17.782 1.00 34.34  ? 71  ASP A CA   1 
ATOM   521  C C    . ASP A 1 84  ? 20.395  -32.031 -17.794 1.00 31.85  ? 71  ASP A C    1 
ATOM   522  O O    . ASP A 1 84  ? 19.442  -32.146 -17.038 1.00 29.25  ? 71  ASP A O    1 
ATOM   523  C CB   . ASP A 1 84  ? 21.530  -30.292 -16.359 1.00 43.03  ? 71  ASP A CB   1 
ATOM   524  C CG   . ASP A 1 84  ? 22.092  -31.317 -15.359 1.00 44.26  ? 71  ASP A CG   1 
ATOM   525  O OD1  . ASP A 1 84  ? 22.103  -32.550 -15.632 1.00 41.26  ? 71  ASP A OD1  1 
ATOM   526  O OD2  . ASP A 1 84  ? 22.505  -30.874 -14.271 1.00 53.50  ? 71  ASP A OD2  1 
ATOM   527  N N    . ILE A 1 85  ? 20.799  -32.997 -18.623 1.00 33.85  ? 72  ILE A N    1 
ATOM   528  C CA   . ILE A 1 85  ? 20.008  -34.189 -18.835 1.00 33.73  ? 72  ILE A CA   1 
ATOM   529  C C    . ILE A 1 85  ? 19.937  -35.029 -17.563 1.00 31.37  ? 72  ILE A C    1 
ATOM   530  O O    . ILE A 1 85  ? 18.942  -35.720 -17.329 1.00 32.24  ? 72  ILE A O    1 
ATOM   531  C CB   . ILE A 1 85  ? 20.503  -34.998 -20.048 1.00 31.24  ? 72  ILE A CB   1 
ATOM   532  C CG1  . ILE A 1 85  ? 20.417  -34.174 -21.353 1.00 36.66  ? 72  ILE A CG1  1 
ATOM   533  C CG2  . ILE A 1 85  ? 19.753  -36.339 -20.138 1.00 32.09  ? 72  ILE A CG2  1 
ATOM   534  C CD1  . ILE A 1 85  ? 19.049  -33.547 -21.643 1.00 34.74  ? 72  ILE A CD1  1 
ATOM   535  N N    . GLU A 1 86  ? 21.000  -34.980 -16.765 1.00 37.35  ? 73  GLU A N    1 
ATOM   536  C CA   . GLU A 1 86  ? 21.076  -35.784 -15.553 1.00 41.36  ? 73  GLU A CA   1 
ATOM   537  C C    . GLU A 1 86  ? 20.004  -35.322 -14.562 1.00 31.06  ? 73  GLU A C    1 
ATOM   538  O O    . GLU A 1 86  ? 19.262  -36.129 -14.023 1.00 33.40  ? 73  GLU A O    1 
ATOM   539  C CB   . GLU A 1 86  ? 22.493  -35.787 -14.966 1.00 44.54  ? 73  GLU A CB   1 
ATOM   540  C CG   . GLU A 1 86  ? 22.858  -37.155 -14.396 1.00 49.89  ? 73  GLU A CG   1 
ATOM   541  C CD   . GLU A 1 86  ? 22.874  -38.215 -15.493 1.00 57.57  ? 73  GLU A CD   1 
ATOM   542  O OE1  . GLU A 1 86  ? 23.629  -38.006 -16.485 1.00 55.56  ? 73  GLU A OE1  1 
ATOM   543  O OE2  . GLU A 1 86  ? 22.140  -39.229 -15.388 1.00 50.51  ? 73  GLU A OE2  1 
ATOM   544  N N    . ARG A 1 87  ? 19.903  -34.009 -14.380 1.00 29.59  ? 74  ARG A N    1 
ATOM   545  C CA   . ARG A 1 87  ? 18.868  -33.396 -13.552 1.00 29.45  ? 74  ARG A CA   1 
ATOM   546  C C    . ARG A 1 87  ? 17.466  -33.654 -14.133 1.00 28.62  ? 74  ARG A C    1 
ATOM   547  O O    . ARG A 1 87  ? 16.532  -34.018 -13.405 1.00 33.40  ? 74  ARG A O    1 
ATOM   548  C CB   . ARG A 1 87  ? 19.203  -31.903 -13.423 1.00 36.75  ? 74  ARG A CB   1 
ATOM   549  C CG   . ARG A 1 87  ? 18.187  -31.132 -12.582 1.00 39.23  ? 74  ARG A CG   1 
ATOM   550  C CD   . ARG A 1 87  ? 18.243  -31.495 -11.094 1.00 40.06  ? 74  ARG A CD   1 
ATOM   551  N NE   . ARG A 1 87  ? 17.090  -30.908 -10.403 1.00 38.92  ? 74  ARG A NE   1 
ATOM   552  C CZ   . ARG A 1 87  ? 16.333  -31.552 -9.503  1.00 41.73  ? 74  ARG A CZ   1 
ATOM   553  N NH1  . ARG A 1 87  ? 16.637  -32.793 -9.141  1.00 43.09  ? 74  ARG A NH1  1 
ATOM   554  N NH2  . ARG A 1 87  ? 15.286  -30.945 -8.966  1.00 29.92  ? 74  ARG A NH2  1 
ATOM   555  N N    . LEU A 1 88  ? 17.319  -33.467 -15.449 1.00 34.64  ? 75  LEU A N    1 
ATOM   556  C CA   . LEU A 1 88  ? 16.086  -33.812 -16.144 1.00 31.14  ? 75  LEU A CA   1 
ATOM   557  C C    . LEU A 1 88  ? 15.647  -35.224 -15.782 1.00 31.26  ? 75  LEU A C    1 
ATOM   558  O O    . LEU A 1 88  ? 14.497  -35.412 -15.417 1.00 28.09  ? 75  LEU A O    1 
ATOM   559  C CB   . LEU A 1 88  ? 16.166  -33.640 -17.665 1.00 33.79  ? 75  LEU A CB   1 
ATOM   560  C CG   . LEU A 1 88  ? 14.936  -34.075 -18.474 1.00 30.79  ? 75  LEU A CG   1 
ATOM   561  C CD1  . LEU A 1 88  ? 13.746  -33.166 -18.175 1.00 33.02  ? 75  LEU A CD1  1 
ATOM   562  C CD2  . LEU A 1 88  ? 15.320  -33.966 -19.959 1.00 27.62  ? 75  LEU A CD2  1 
ATOM   563  N N    . LYS A 1 89  ? 16.539  -36.215 -15.918 1.00 28.80  ? 76  LYS A N    1 
ATOM   564  C CA   . LYS A 1 89  ? 16.143  -37.578 -15.577 1.00 32.79  ? 76  LYS A CA   1 
ATOM   565  C C    . LYS A 1 89  ? 15.867  -37.733 -14.080 1.00 29.85  ? 76  LYS A C    1 
ATOM   566  O O    . LYS A 1 89  ? 15.052  -38.566 -13.694 1.00 30.93  ? 76  LYS A O    1 
ATOM   567  C CB   . LYS A 1 89  ? 17.186  -38.634 -15.995 1.00 31.20  ? 76  LYS A CB   1 
ATOM   568  C CG   . LYS A 1 89  ? 17.480  -38.573 -17.499 1.00 28.95  ? 76  LYS A CG   1 
ATOM   569  N N    . ALA A 1 90  ? 16.557  -36.956 -13.235 1.00 29.32  ? 77  ALA A N    1 
ATOM   570  C CA   . ALA A 1 90  ? 16.271  -37.074 -11.812 1.00 33.62  ? 77  ALA A CA   1 
ATOM   571  C C    . ALA A 1 90  ? 14.896  -36.491 -11.493 1.00 31.44  ? 77  ALA A C    1 
ATOM   572  O O    . ALA A 1 90  ? 14.155  -37.059 -10.688 1.00 32.56  ? 77  ALA A O    1 
ATOM   573  C CB   . ALA A 1 90  ? 17.364  -36.464 -10.948 1.00 29.84  ? 77  ALA A CB   1 
ATOM   574  N N    . CYS A 1 91  ? 14.557  -35.374 -12.152 1.00 29.86  ? 78  CYS A N    1 
ATOM   575  C CA   . CYS A 1 91  ? 13.232  -34.789 -11.980 1.00 29.85  ? 78  CYS A CA   1 
ATOM   576  C C    . CYS A 1 91  ? 12.134  -35.784 -12.319 1.00 27.01  ? 78  CYS A C    1 
ATOM   577  O O    . CYS A 1 91  ? 11.167  -35.914 -11.583 1.00 27.89  ? 78  CYS A O    1 
ATOM   578  C CB   . CYS A 1 91  ? 13.080  -33.539 -12.821 1.00 29.69  ? 78  CYS A CB   1 
ATOM   579  S SG   . CYS A 1 91  ? 14.075  -32.203 -12.129 1.00 33.88  ? 78  CYS A SG   1 
ATOM   580  N N    . VAL A 1 92  ? 12.299  -36.502 -13.434 1.00 30.65  ? 79  VAL A N    1 
ATOM   581  C CA   . VAL A 1 92  ? 11.318  -37.470 -13.889 1.00 28.48  ? 79  VAL A CA   1 
ATOM   582  C C    . VAL A 1 92  ? 11.184  -38.564 -12.832 1.00 30.80  ? 79  VAL A C    1 
ATOM   583  O O    . VAL A 1 92  ? 10.071  -38.904 -12.442 1.00 32.29  ? 79  VAL A O    1 
ATOM   584  C CB   . VAL A 1 92  ? 11.682  -38.044 -15.282 1.00 31.02  ? 79  VAL A CB   1 
ATOM   585  C CG1  . VAL A 1 92  ? 10.853  -39.257 -15.657 1.00 30.55  ? 79  VAL A CG1  1 
ATOM   586  C CG2  . VAL A 1 92  ? 11.537  -36.996 -16.377 1.00 31.46  ? 79  VAL A CG2  1 
ATOM   587  N N    . ALA A 1 93  ? 12.318  -39.127 -12.404 1.00 35.08  ? 80  ALA A N    1 
ATOM   588  C CA   . ALA A 1 93  ? 12.313  -40.251 -11.472 1.00 33.00  ? 80  ALA A CA   1 
ATOM   589  C C    . ALA A 1 93  ? 11.607  -39.828 -10.181 1.00 30.30  ? 80  ALA A C    1 
ATOM   590  O O    . ALA A 1 93  ? 10.900  -40.605 -9.543  1.00 31.31  ? 80  ALA A O    1 
ATOM   591  C CB   . ALA A 1 93  ? 13.749  -40.681 -11.221 1.00 35.07  ? 80  ALA A CB   1 
ATOM   592  N N    . GLU A 1 94  ? 11.783  -38.560 -9.788  1.00 33.08  ? 81  GLU A N    1 
ATOM   593  C CA   . GLU A 1 94  ? 11.194  -38.061 -8.546  1.00 32.79  ? 81  GLU A CA   1 
ATOM   594  C C    . GLU A 1 94  ? 9.676   -37.937 -8.693  1.00 32.99  ? 81  GLU A C    1 
ATOM   595  O O    . GLU A 1 94  ? 8.925   -38.271 -7.777  1.00 34.90  ? 81  GLU A O    1 
ATOM   596  C CB   . GLU A 1 94  ? 11.814  -36.747 -8.081  1.00 32.53  ? 81  GLU A CB   1 
ATOM   597  C CG   . GLU A 1 94  ? 11.316  -36.312 -6.706  1.00 42.68  ? 81  GLU A CG   1 
ATOM   598  C CD   . GLU A 1 94  ? 11.747  -34.908 -6.299  1.00 46.03  ? 81  GLU A CD   1 
ATOM   599  O OE1  . GLU A 1 94  ? 12.954  -34.596 -6.422  1.00 51.67  ? 81  GLU A OE1  1 
ATOM   600  O OE2  . GLU A 1 94  ? 10.884  -34.129 -5.838  1.00 50.54  ? 81  GLU A OE2  1 
ATOM   601  N N    . VAL A 1 95  ? 9.231   -37.450 -9.857  1.00 31.63  ? 82  VAL A N    1 
ATOM   602  C CA   . VAL A 1 95  ? 7.807   -37.411 -10.150 1.00 26.35  ? 82  VAL A CA   1 
ATOM   603  C C    . VAL A 1 95  ? 7.228   -38.824 -10.066 1.00 26.63  ? 82  VAL A C    1 
ATOM   604  O O    . VAL A 1 95  ? 6.205   -39.031 -9.437  1.00 32.96  ? 82  VAL A O    1 
ATOM   605  C CB   . VAL A 1 95  ? 7.471   -36.693 -11.466 1.00 25.19  ? 82  VAL A CB   1 
ATOM   606  C CG1  . VAL A 1 95  ? 5.993   -36.869 -11.832 1.00 26.89  ? 82  VAL A CG1  1 
ATOM   607  C CG2  . VAL A 1 95  ? 7.852   -35.202 -11.381 1.00 24.97  ? 82  VAL A CG2  1 
ATOM   608  N N    . GLU A 1 96  ? 7.889   -39.786 -10.691 1.00 29.18  ? 83  GLU A N    1 
ATOM   609  C CA   . GLU A 1 96  ? 7.434   -41.170 -10.710 1.00 35.33  ? 83  GLU A CA   1 
ATOM   610  C C    . GLU A 1 96  ? 7.289   -41.736 -9.304  1.00 34.75  ? 83  GLU A C    1 
ATOM   611  O O    . GLU A 1 96  ? 6.330   -42.461 -9.043  1.00 41.90  ? 83  GLU A O    1 
ATOM   612  C CB   . GLU A 1 96  ? 8.388   -42.048 -11.522 1.00 38.77  ? 83  GLU A CB   1 
ATOM   613  C CG   . GLU A 1 96  ? 8.266   -41.758 -13.013 1.00 50.97  ? 83  GLU A CG   1 
ATOM   614  C CD   . GLU A 1 96  ? 8.969   -42.721 -13.960 1.00 51.72  ? 83  GLU A CD   1 
ATOM   615  O OE1  . GLU A 1 96  ? 10.189  -42.911 -13.784 1.00 44.86  ? 83  GLU A OE1  1 
ATOM   616  O OE2  . GLU A 1 96  ? 8.298   -43.278 -14.861 1.00 54.92  ? 83  GLU A OE2  1 
ATOM   617  N N    . ARG A 1 97  ? 8.249   -41.429 -8.422  1.00 40.58  ? 84  ARG A N    1 
ATOM   618  C CA   . ARG A 1 97  ? 8.230   -41.947 -7.063  1.00 40.23  ? 84  ARG A CA   1 
ATOM   619  C C    . ARG A 1 97  ? 7.080   -41.297 -6.292  1.00 42.29  ? 84  ARG A C    1 
ATOM   620  O O    . ARG A 1 97  ? 6.398   -41.977 -5.542  1.00 42.04  ? 84  ARG A O    1 
ATOM   621  C CB   . ARG A 1 97  ? 9.563   -41.760 -6.324  1.00 50.64  ? 84  ARG A CB   1 
ATOM   622  C CG   . ARG A 1 97  ? 10.765  -42.622 -6.687  1.00 55.51  ? 84  ARG A CG   1 
ATOM   623  C CD   . ARG A 1 97  ? 11.885  -42.412 -5.651  1.00 47.40  ? 84  ARG A CD   1 
ATOM   624  N NE   . ARG A 1 97  ? 12.373  -41.031 -5.514  1.00 39.64  ? 84  ARG A NE   1 
ATOM   625  C CZ   . ARG A 1 97  ? 13.305  -40.434 -6.267  1.00 35.88  ? 84  ARG A CZ   1 
ATOM   626  N NH1  . ARG A 1 97  ? 13.950  -41.097 -7.217  1.00 29.72  ? 84  ARG A NH1  1 
ATOM   627  N NH2  . ARG A 1 97  ? 13.579  -39.157 -6.085  1.00 32.64  ? 84  ARG A NH2  1 
ATOM   628  N N    . THR A 1 98  ? 6.835   -39.994 -6.505  1.00 30.29  ? 85  THR A N    1 
ATOM   629  C CA   . THR A 1 98  ? 5.758   -39.314 -5.810  1.00 32.78  ? 85  THR A CA   1 
ATOM   630  C C    . THR A 1 98  ? 4.401   -39.860 -6.238  1.00 31.30  ? 85  THR A C    1 
ATOM   631  O O    . THR A 1 98  ? 3.615   -40.332 -5.420  1.00 41.28  ? 85  THR A O    1 
ATOM   632  C CB   . THR A 1 98  ? 5.885   -37.796 -5.997  1.00 34.29  ? 85  THR A CB   1 
ATOM   633  O OG1  . THR A 1 98  ? 7.227   -37.554 -5.606  1.00 34.24  ? 85  THR A OG1  1 
ATOM   634  C CG2  . THR A 1 98  ? 4.952   -36.990 -5.103  1.00 35.65  ? 85  THR A CG2  1 
ATOM   635  N N    . TRP A 1 99  ? 4.130   -39.842 -7.543  1.00 35.04  ? 86  TRP A N    1 
ATOM   636  C CA   . TRP A 1 99  ? 2.779   -39.943 -8.070  1.00 31.44  ? 86  TRP A CA   1 
ATOM   637  C C    . TRP A 1 99  ? 2.597   -41.149 -8.983  1.00 36.68  ? 86  TRP A C    1 
ATOM   638  O O    . TRP A 1 99  ? 1.477   -41.347 -9.464  1.00 38.16  ? 86  TRP A O    1 
ATOM   639  C CB   . TRP A 1 99  ? 2.457   -38.668 -8.863  1.00 27.56  ? 86  TRP A CB   1 
ATOM   640  C CG   . TRP A 1 99  ? 2.104   -37.511 -7.966  1.00 28.45  ? 86  TRP A CG   1 
ATOM   641  C CD1  . TRP A 1 99  ? 1.690   -37.581 -6.669  1.00 29.89  ? 86  TRP A CD1  1 
ATOM   642  C CD2  . TRP A 1 99  ? 2.133   -36.114 -8.316  1.00 27.60  ? 86  TRP A CD2  1 
ATOM   643  N NE1  . TRP A 1 99  ? 1.429   -36.320 -6.193  1.00 33.17  ? 86  TRP A NE1  1 
ATOM   644  C CE2  . TRP A 1 99  ? 1.714   -35.401 -7.170  1.00 31.82  ? 86  TRP A CE2  1 
ATOM   645  C CE3  . TRP A 1 99  ? 2.482   -35.402 -9.471  1.00 26.97  ? 86  TRP A CE3  1 
ATOM   646  C CZ2  . TRP A 1 99  ? 1.611   -34.011 -7.153  1.00 32.26  ? 86  TRP A CZ2  1 
ATOM   647  C CZ3  . TRP A 1 99  ? 2.378   -34.027 -9.449  1.00 28.45  ? 86  TRP A CZ3  1 
ATOM   648  C CH2  . TRP A 1 99  ? 1.981   -33.344 -8.303  1.00 30.73  ? 86  TRP A CH2  1 
ATOM   649  N N    . GLY A 1 100 ? 3.685   -41.884 -9.281  1.00 39.98  ? 87  GLY A N    1 
ATOM   650  C CA   . GLY A 1 100 ? 3.623   -42.958 -10.273 1.00 38.52  ? 87  GLY A CA   1 
ATOM   651  C C    . GLY A 1 100 ? 3.989   -42.468 -11.685 1.00 43.65  ? 87  GLY A C    1 
ATOM   652  O O    . GLY A 1 100 ? 4.405   -41.310 -11.879 1.00 34.18  ? 87  GLY A O    1 
ATOM   653  N N    . ALA A 1 101 ? 3.834   -43.373 -12.669 1.00 36.35  ? 88  ALA A N    1 
ATOM   654  C CA   . ALA A 1 101 ? 4.118   -43.130 -14.080 1.00 35.21  ? 88  ALA A CA   1 
ATOM   655  C C    . ALA A 1 101 ? 3.465   -41.833 -14.568 1.00 29.22  ? 88  ALA A C    1 
ATOM   656  O O    . ALA A 1 101 ? 2.315   -41.555 -14.248 1.00 36.85  ? 88  ALA A O    1 
ATOM   657  C CB   . ALA A 1 101 ? 3.586   -44.298 -14.859 1.00 34.30  ? 88  ALA A CB   1 
ATOM   658  N N    . VAL A 1 102 ? 4.192   -41.023 -15.336 1.00 31.28  ? 89  VAL A N    1 
ATOM   659  C CA   . VAL A 1 102 ? 3.566   -39.853 -15.945 1.00 30.81  ? 89  VAL A CA   1 
ATOM   660  C C    . VAL A 1 102 ? 2.478   -40.297 -16.936 1.00 27.31  ? 89  VAL A C    1 
ATOM   661  O O    . VAL A 1 102 ? 2.667   -41.238 -17.696 1.00 27.80  ? 89  VAL A O    1 
ATOM   662  C CB   . VAL A 1 102 ? 4.647   -38.969 -16.588 1.00 29.33  ? 89  VAL A CB   1 
ATOM   663  C CG1  . VAL A 1 102 ? 4.083   -37.727 -17.286 1.00 28.88  ? 89  VAL A CG1  1 
ATOM   664  C CG2  . VAL A 1 102 ? 5.683   -38.553 -15.555 1.00 31.03  ? 89  VAL A CG2  1 
ATOM   665  N N    . ASP A 1 103 ? 1.349   -39.587 -16.943 1.00 27.59  ? 90  ASP A N    1 
ATOM   666  C CA   . ASP A 1 103 ? 0.302   -39.776 -17.939 1.00 28.08  ? 90  ASP A CA   1 
ATOM   667  C C    . ASP A 1 103 ? 0.514   -38.843 -19.136 1.00 29.90  ? 90  ASP A C    1 
ATOM   668  O O    . ASP A 1 103 ? 0.384   -39.283 -20.263 1.00 28.74  ? 90  ASP A O    1 
ATOM   669  C CB   . ASP A 1 103 ? -1.087  -39.618 -17.342 1.00 32.01  ? 90  ASP A CB   1 
ATOM   670  C CG   . ASP A 1 103 ? -1.477  -40.649 -16.291 1.00 35.36  ? 90  ASP A CG   1 
ATOM   671  O OD1  . ASP A 1 103 ? -1.669  -41.812 -16.686 1.00 41.49  ? 90  ASP A OD1  1 
ATOM   672  O OD2  . ASP A 1 103 ? -1.560  -40.281 -15.096 1.00 33.00  ? 90  ASP A OD2  1 
ATOM   673  N N    . VAL A 1 104 ? 0.817   -37.554 -18.881 1.00 29.68  ? 91  VAL A N    1 
ATOM   674  C CA   . VAL A 1 104 ? 0.919   -36.571 -19.947 1.00 27.02  ? 91  VAL A CA   1 
ATOM   675  C C    . VAL A 1 104 ? 2.270   -35.871 -19.806 1.00 24.84  ? 91  VAL A C    1 
ATOM   676  O O    . VAL A 1 104 ? 2.526   -35.326 -18.744 1.00 26.71  ? 91  VAL A O    1 
ATOM   677  C CB   . VAL A 1 104 ? -0.205  -35.503 -19.919 1.00 28.83  ? 91  VAL A CB   1 
ATOM   678  C CG1  . VAL A 1 104 ? -0.045  -34.522 -21.086 1.00 27.25  ? 91  VAL A CG1  1 
ATOM   679  C CG2  . VAL A 1 104 ? -1.592  -36.111 -19.971 1.00 29.60  ? 91  VAL A CG2  1 
ATOM   680  N N    . LEU A 1 105 ? 3.109   -35.883 -20.851 1.00 24.01  ? 92  LEU A N    1 
ATOM   681  C CA   . LEU A 1 105 ? 4.316   -35.069 -20.863 1.00 25.92  ? 92  LEU A CA   1 
ATOM   682  C C    . LEU A 1 105 ? 4.147   -33.916 -21.853 1.00 21.36  ? 92  LEU A C    1 
ATOM   683  O O    . LEU A 1 105 ? 3.789   -34.117 -23.000 1.00 23.24  ? 92  LEU A O    1 
ATOM   684  C CB   . LEU A 1 105 ? 5.549   -35.924 -21.175 1.00 28.94  ? 92  LEU A CB   1 
ATOM   685  C CG   . LEU A 1 105 ? 6.838   -35.163 -21.567 1.00 28.44  ? 92  LEU A CG   1 
ATOM   686  C CD1  . LEU A 1 105 ? 7.535   -34.396 -20.414 1.00 25.42  ? 92  LEU A CD1  1 
ATOM   687  C CD2  . LEU A 1 105 ? 7.866   -36.101 -22.229 1.00 26.13  ? 92  LEU A CD2  1 
ATOM   688  N N    . ILE A 1 106 ? 4.500   -32.701 -21.421 1.00 25.32  ? 93  ILE A N    1 
ATOM   689  C CA   . ILE A 1 106 ? 4.487   -31.574 -22.332 1.00 25.76  ? 93  ILE A CA   1 
ATOM   690  C C    . ILE A 1 106 ? 5.895   -30.981 -22.403 1.00 26.03  ? 93  ILE A C    1 
ATOM   691  O O    . ILE A 1 106 ? 6.382   -30.377 -21.462 1.00 23.83  ? 93  ILE A O    1 
ATOM   692  C CB   . ILE A 1 106 ? 3.433   -30.540 -21.894 1.00 28.55  ? 93  ILE A CB   1 
ATOM   693  C CG1  . ILE A 1 106 ? 2.079   -31.224 -21.683 1.00 27.91  ? 93  ILE A CG1  1 
ATOM   694  C CG2  . ILE A 1 106 ? 3.345   -29.390 -22.924 1.00 26.31  ? 93  ILE A CG2  1 
ATOM   695  C CD1  . ILE A 1 106 ? 0.897   -30.280 -21.535 1.00 22.79  ? 93  ILE A CD1  1 
ATOM   696  N N    . ASN A 1 107 ? 6.558   -31.187 -23.551 1.00 28.68  ? 94  ASN A N    1 
ATOM   697  C CA   . ASN A 1 107 ? 7.892   -30.664 -23.767 1.00 23.80  ? 94  ASN A CA   1 
ATOM   698  C C    . ASN A 1 107 ? 7.707   -29.240 -24.251 1.00 21.91  ? 94  ASN A C    1 
ATOM   699  O O    . ASN A 1 107 ? 7.371   -29.046 -25.414 1.00 21.47  ? 94  ASN A O    1 
ATOM   700  C CB   . ASN A 1 107 ? 8.596   -31.490 -24.842 1.00 22.96  ? 94  ASN A CB   1 
ATOM   701  C CG   . ASN A 1 107 ? 8.979   -32.854 -24.309 1.00 24.21  ? 94  ASN A CG   1 
ATOM   702  O OD1  . ASN A 1 107 ? 9.449   -32.992 -23.174 1.00 23.51  ? 94  ASN A OD1  1 
ATOM   703  N ND2  . ASN A 1 107 ? 8.784   -33.880 -25.116 1.00 26.51  ? 94  ASN A ND2  1 
ATOM   704  N N    . ASN A 1 108 ? 7.851   -28.284 -23.325 1.00 24.96  ? 95  ASN A N    1 
ATOM   705  C CA   . ASN A 1 108 ? 7.490   -26.900 -23.561 1.00 22.67  ? 95  ASN A CA   1 
ATOM   706  C C    . ASN A 1 108 ? 8.737   -26.023 -23.470 1.00 24.48  ? 95  ASN A C    1 
ATOM   707  O O    . ASN A 1 108 ? 8.813   -25.005 -24.145 1.00 23.29  ? 95  ASN A O    1 
ATOM   708  C CB   . ASN A 1 108 ? 6.380   -26.436 -22.605 1.00 24.33  ? 95  ASN A CB   1 
ATOM   709  C CG   . ASN A 1 108 ? 6.172   -24.926 -22.660 1.00 23.65  ? 95  ASN A CG   1 
ATOM   710  O OD1  . ASN A 1 108 ? 5.603   -24.438 -23.640 1.00 19.99  ? 95  ASN A OD1  1 
ATOM   711  N ND2  . ASN A 1 108 ? 6.650   -24.176 -21.659 1.00 22.25  ? 95  ASN A ND2  1 
ATOM   712  N N    . ALA A 1 109 ? 9.754   -26.404 -22.684 1.00 23.57  ? 96  ALA A N    1 
ATOM   713  C CA   . ALA A 1 109 ? 10.841  -25.468 -22.426 1.00 24.78  ? 96  ALA A CA   1 
ATOM   714  C C    . ALA A 1 109 ? 11.579  -25.086 -23.719 1.00 23.99  ? 96  ALA A C    1 
ATOM   715  O O    . ALA A 1 109 ? 11.915  -25.920 -24.547 1.00 21.99  ? 96  ALA A O    1 
ATOM   716  C CB   . ALA A 1 109 ? 11.802  -26.041 -21.384 1.00 22.69  ? 96  ALA A CB   1 
ATOM   717  N N    . ALA A 1 110 ? 11.859  -23.792 -23.878 1.00 22.05  ? 97  ALA A N    1 
ATOM   718  C CA   . ALA A 1 110 ? 12.458  -23.364 -25.125 1.00 26.09  ? 97  ALA A CA   1 
ATOM   719  C C    . ALA A 1 110 ? 12.991  -21.952 -24.938 1.00 31.29  ? 97  ALA A C    1 
ATOM   720  O O    . ALA A 1 110 ? 12.548  -21.283 -24.012 1.00 27.10  ? 97  ALA A O    1 
ATOM   721  C CB   . ALA A 1 110 ? 11.361  -23.366 -26.222 1.00 30.59  ? 97  ALA A CB   1 
ATOM   722  N N    . ARG A 1 111 ? 13.836  -21.500 -25.887 1.00 31.56  ? 98  ARG A N    1 
ATOM   723  C CA   . ARG A 1 111 ? 14.419  -20.162 -25.876 1.00 32.57  ? 98  ARG A CA   1 
ATOM   724  C C    . ARG A 1 111 ? 14.362  -19.623 -27.297 1.00 28.92  ? 98  ARG A C    1 
ATOM   725  O O    . ARG A 1 111 ? 15.040  -20.152 -28.154 1.00 33.10  ? 98  ARG A O    1 
ATOM   726  C CB   . ARG A 1 111 ? 15.869  -20.193 -25.371 1.00 35.22  ? 98  ARG A CB   1 
ATOM   727  N N    . ASP A 1 112 ? 13.572  -18.565 -27.529 1.00 29.58  ? 99  ASP A N    1 
ATOM   728  C CA   . ASP A 1 112 ? 13.366  -18.077 -28.882 1.00 34.73  ? 99  ASP A CA   1 
ATOM   729  C C    . ASP A 1 112 ? 14.116  -16.760 -29.129 1.00 39.65  ? 99  ASP A C    1 
ATOM   730  O O    . ASP A 1 112 ? 13.740  -16.021 -30.050 1.00 37.14  ? 99  ASP A O    1 
ATOM   731  C CB   . ASP A 1 112 ? 11.877  -17.960 -29.186 1.00 33.95  ? 99  ASP A CB   1 
ATOM   732  C CG   . ASP A 1 112 ? 11.183  -16.815 -28.456 1.00 39.70  ? 99  ASP A CG   1 
ATOM   733  O OD1  . ASP A 1 112 ? 11.730  -16.354 -27.426 1.00 36.12  ? 99  ASP A OD1  1 
ATOM   734  O OD2  . ASP A 1 112 ? 10.139  -16.357 -28.945 1.00 43.60  ? 99  ASP A OD2  1 
ATOM   735  N N    . ASP A 1 113 ? 15.153  -16.479 -28.315 1.00 32.85  ? 100 ASP A N    1 
ATOM   736  C CA   . ASP A 1 113 ? 15.968  -15.281 -28.492 1.00 41.31  ? 100 ASP A CA   1 
ATOM   737  C C    . ASP A 1 113 ? 16.441  -15.184 -29.944 1.00 36.16  ? 100 ASP A C    1 
ATOM   738  O O    . ASP A 1 113 ? 16.945  -16.163 -30.506 1.00 41.90  ? 100 ASP A O    1 
ATOM   739  C CB   . ASP A 1 113 ? 17.165  -15.265 -27.543 1.00 44.05  ? 100 ASP A CB   1 
ATOM   740  C CG   . ASP A 1 113 ? 16.803  -15.410 -26.070 1.00 47.81  ? 100 ASP A CG   1 
ATOM   741  O OD1  . ASP A 1 113 ? 16.477  -16.538 -25.661 1.00 40.38  ? 100 ASP A OD1  1 
ATOM   742  O OD2  . ASP A 1 113 ? 16.801  -14.386 -25.359 1.00 51.05  ? 100 ASP A OD2  1 
ATOM   743  N N    . ARG A 1 114 ? 16.274  -13.993 -30.523 1.00 36.14  ? 101 ARG A N    1 
ATOM   744  C CA   . ARG A 1 114 ? 16.664  -13.691 -31.894 1.00 41.92  ? 101 ARG A CA   1 
ATOM   745  C C    . ARG A 1 114 ? 18.181  -13.763 -32.046 1.00 42.15  ? 101 ARG A C    1 
ATOM   746  O O    . ARG A 1 114 ? 18.916  -13.473 -31.107 1.00 44.60  ? 101 ARG A O    1 
ATOM   747  C CB   . ARG A 1 114 ? 16.112  -12.348 -32.405 1.00 39.05  ? 101 ARG A CB   1 
ATOM   748  C CG   . ARG A 1 114 ? 14.598  -12.192 -32.434 1.00 48.68  ? 101 ARG A CG   1 
ATOM   749  C CD   . ARG A 1 114 ? 13.855  -13.470 -32.819 1.00 51.61  ? 101 ARG A CD   1 
ATOM   750  N NE   . ARG A 1 114 ? 12.434  -13.367 -33.188 1.00 50.60  ? 101 ARG A NE   1 
ATOM   751  C CZ   . ARG A 1 114 ? 11.391  -13.841 -32.487 1.00 48.19  ? 101 ARG A CZ   1 
ATOM   752  N NH1  . ARG A 1 114 ? 11.550  -14.362 -31.271 1.00 46.74  ? 101 ARG A NH1  1 
ATOM   753  N NH2  . ARG A 1 114 ? 10.175  -13.768 -32.997 1.00 42.89  ? 101 ARG A NH2  1 
ATOM   754  N N    . HIS A 1 115 ? 18.641  -14.208 -33.227 1.00 39.90  ? 102 HIS A N    1 
ATOM   755  C CA   . HIS A 1 115 ? 20.059  -14.284 -33.503 1.00 36.47  ? 102 HIS A CA   1 
ATOM   756  C C    . HIS A 1 115 ? 20.287  -14.311 -35.009 1.00 42.20  ? 102 HIS A C    1 
ATOM   757  O O    . HIS A 1 115 ? 19.564  -15.000 -35.729 1.00 37.66  ? 102 HIS A O    1 
ATOM   758  C CB   . HIS A 1 115 ? 20.672  -15.496 -32.796 1.00 38.72  ? 102 HIS A CB   1 
ATOM   759  C CG   . HIS A 1 115 ? 20.050  -16.842 -33.036 1.00 39.21  ? 102 HIS A CG   1 
ATOM   760  N ND1  . HIS A 1 115 ? 19.093  -17.370 -32.191 1.00 31.47  ? 102 HIS A ND1  1 
ATOM   761  C CD2  . HIS A 1 115 ? 20.313  -17.807 -33.954 1.00 37.93  ? 102 HIS A CD2  1 
ATOM   762  C CE1  . HIS A 1 115 ? 18.785  -18.600 -32.599 1.00 34.34  ? 102 HIS A CE1  1 
ATOM   763  N NE2  . HIS A 1 115 ? 19.521  -18.898 -33.654 1.00 35.32  ? 102 HIS A NE2  1 
ATOM   764  N N    . ALA A 1 116 ? 21.357  -13.617 -35.451 1.00 39.78  ? 103 ALA A N    1 
ATOM   765  C CA   . ALA A 1 116 ? 21.683  -13.508 -36.864 1.00 37.45  ? 103 ALA A CA   1 
ATOM   766  C C    . ALA A 1 116 ? 22.404  -14.766 -37.357 1.00 38.08  ? 103 ALA A C    1 
ATOM   767  O O    . ALA A 1 116 ? 23.361  -15.252 -36.720 1.00 38.55  ? 103 ALA A O    1 
ATOM   768  C CB   . ALA A 1 116 ? 22.481  -12.236 -37.118 1.00 43.42  ? 103 ALA A CB   1 
ATOM   769  N N    . LEU A 1 117 ? 21.960  -15.265 -38.526 1.00 34.32  ? 104 LEU A N    1 
ATOM   770  C CA   . LEU A 1 117 ? 22.538  -16.459 -39.150 1.00 36.95  ? 104 LEU A CA   1 
ATOM   771  C C    . LEU A 1 117 ? 24.067  -16.393 -39.139 1.00 39.68  ? 104 LEU A C    1 
ATOM   772  O O    . LEU A 1 117 ? 24.750  -17.350 -38.758 1.00 45.93  ? 104 LEU A O    1 
ATOM   773  C CB   . LEU A 1 117 ? 22.043  -16.620 -40.591 1.00 37.46  ? 104 LEU A CB   1 
ATOM   774  N N    . ALA A 1 118 ? 24.590  -15.254 -39.619 1.00 38.39  ? 105 ALA A N    1 
ATOM   775  C CA   . ALA A 1 118 ? 26.003  -15.087 -39.930 1.00 41.45  ? 105 ALA A CA   1 
ATOM   776  C C    . ALA A 1 118 ? 26.859  -15.152 -38.663 1.00 40.49  ? 105 ALA A C    1 
ATOM   777  O O    . ALA A 1 118 ? 28.032  -15.521 -38.766 1.00 39.42  ? 105 ALA A O    1 
ATOM   778  C CB   . ALA A 1 118 ? 26.199  -13.766 -40.672 1.00 42.55  ? 105 ALA A CB   1 
ATOM   779  N N    . ASP A 1 119 ? 26.263  -14.802 -37.496 1.00 36.53  ? 106 ASP A N    1 
ATOM   780  C CA   . ASP A 1 119 ? 26.989  -14.613 -36.246 1.00 36.58  ? 106 ASP A CA   1 
ATOM   781  C C    . ASP A 1 119 ? 27.034  -15.877 -35.385 1.00 41.36  ? 106 ASP A C    1 
ATOM   782  O O    . ASP A 1 119 ? 27.826  -15.935 -34.458 1.00 39.98  ? 106 ASP A O    1 
ATOM   783  C CB   . ASP A 1 119 ? 26.439  -13.430 -35.456 1.00 32.07  ? 106 ASP A CB   1 
ATOM   784  C CG   . ASP A 1 119 ? 26.645  -12.069 -36.108 1.00 31.84  ? 106 ASP A CG   1 
ATOM   785  O OD1  . ASP A 1 119 ? 27.516  -11.938 -36.987 1.00 33.08  ? 106 ASP A OD1  1 
ATOM   786  O OD2  . ASP A 1 119 ? 25.927  -11.147 -35.761 1.00 44.40  ? 106 ASP A OD2  1 
ATOM   787  N N    . VAL A 1 120 ? 26.184  -16.875 -35.647 1.00 38.64  ? 107 VAL A N    1 
ATOM   788  C CA   . VAL A 1 120 ? 26.094  -18.036 -34.763 1.00 38.40  ? 107 VAL A CA   1 
ATOM   789  C C    . VAL A 1 120 ? 27.433  -18.764 -34.650 1.00 38.52  ? 107 VAL A C    1 
ATOM   790  O O    . VAL A 1 120 ? 27.962  -19.201 -35.669 1.00 35.19  ? 107 VAL A O    1 
ATOM   791  C CB   . VAL A 1 120 ? 25.035  -19.001 -35.332 1.00 34.79  ? 107 VAL A CB   1 
ATOM   792  C CG1  . VAL A 1 120 ? 25.022  -20.360 -34.625 1.00 31.88  ? 107 VAL A CG1  1 
ATOM   793  C CG2  . VAL A 1 120 ? 23.656  -18.370 -35.343 1.00 31.40  ? 107 VAL A CG2  1 
ATOM   794  N N    . SER A 1 121 ? 27.900  -19.027 -33.411 1.00 33.85  ? 108 SER A N    1 
ATOM   795  C CA   . SER A 1 121 ? 29.130  -19.790 -33.207 1.00 35.09  ? 108 SER A CA   1 
ATOM   796  C C    . SER A 1 121 ? 28.782  -21.259 -32.959 1.00 37.78  ? 108 SER A C    1 
ATOM   797  O O    . SER A 1 121 ? 27.616  -21.565 -32.735 1.00 39.99  ? 108 SER A O    1 
ATOM   798  C CB   . SER A 1 121 ? 29.843  -19.262 -32.006 1.00 37.14  ? 108 SER A CB   1 
ATOM   799  O OG   . SER A 1 121 ? 29.121  -19.707 -30.867 1.00 36.37  ? 108 SER A OG   1 
ATOM   800  N N    . VAL A 1 122 ? 29.794  -22.132 -32.872 1.00 34.28  ? 109 VAL A N    1 
ATOM   801  C CA   . VAL A 1 122 ? 29.573  -23.543 -32.570 1.00 39.29  ? 109 VAL A CA   1 
ATOM   802  C C    . VAL A 1 122 ? 28.963  -23.727 -31.178 1.00 42.61  ? 109 VAL A C    1 
ATOM   803  O O    . VAL A 1 122 ? 28.090  -24.581 -30.978 1.00 51.08  ? 109 VAL A O    1 
ATOM   804  C CB   . VAL A 1 122 ? 30.846  -24.392 -32.747 1.00 38.20  ? 109 VAL A CB   1 
ATOM   805  C CG1  . VAL A 1 122 ? 30.624  -25.863 -32.408 1.00 34.04  ? 109 VAL A CG1  1 
ATOM   806  C CG2  . VAL A 1 122 ? 31.372  -24.279 -34.164 1.00 39.04  ? 109 VAL A CG2  1 
ATOM   807  N N    . GLU A 1 123 ? 29.430  -22.926 -30.212 1.00 47.28  ? 110 GLU A N    1 
ATOM   808  C CA   . GLU A 1 123 ? 28.943  -23.034 -28.844 1.00 42.39  ? 110 GLU A CA   1 
ATOM   809  C C    . GLU A 1 123 ? 27.487  -22.566 -28.751 1.00 37.02  ? 110 GLU A C    1 
ATOM   810  O O    . GLU A 1 123 ? 26.680  -23.184 -28.071 1.00 35.19  ? 110 GLU A O    1 
ATOM   811  C CB   . GLU A 1 123 ? 29.835  -22.346 -27.808 1.00 39.30  ? 110 GLU A CB   1 
ATOM   812  C CG   . GLU A 1 123 ? 31.323  -22.654 -27.979 1.00 46.59  ? 110 GLU A CG   1 
ATOM   813  C CD   . GLU A 1 123 ? 32.063  -21.753 -28.965 1.00 52.02  ? 110 GLU A CD   1 
ATOM   814  O OE1  . GLU A 1 123 ? 31.551  -20.672 -29.366 1.00 60.78  ? 110 GLU A OE1  1 
ATOM   815  O OE2  . GLU A 1 123 ? 33.179  -22.153 -29.332 1.00 56.80  ? 110 GLU A OE2  1 
ATOM   816  N N    . TYR A 1 124 ? 27.152  -21.462 -29.423 1.00 37.43  ? 111 TYR A N    1 
ATOM   817  C CA   . TYR A 1 124 ? 25.801  -20.919 -29.370 1.00 36.40  ? 111 TYR A CA   1 
ATOM   818  C C    . TYR A 1 124 ? 24.819  -21.916 -29.982 1.00 35.27  ? 111 TYR A C    1 
ATOM   819  O O    . TYR A 1 124 ? 23.717  -22.091 -29.472 1.00 32.97  ? 111 TYR A O    1 
ATOM   820  C CB   . TYR A 1 124 ? 25.760  -19.623 -30.174 1.00 33.99  ? 111 TYR A CB   1 
ATOM   821  C CG   . TYR A 1 124 ? 24.431  -18.904 -30.032 1.00 38.20  ? 111 TYR A CG   1 
ATOM   822  C CD1  . TYR A 1 124 ? 23.345  -19.229 -30.849 1.00 34.23  ? 111 TYR A CD1  1 
ATOM   823  C CD2  . TYR A 1 124 ? 24.278  -17.863 -29.123 1.00 35.52  ? 111 TYR A CD2  1 
ATOM   824  C CE1  . TYR A 1 124 ? 22.136  -18.550 -30.734 1.00 36.45  ? 111 TYR A CE1  1 
ATOM   825  C CE2  . TYR A 1 124 ? 23.061  -17.215 -28.960 1.00 35.37  ? 111 TYR A CE2  1 
ATOM   826  C CZ   . TYR A 1 124 ? 21.998  -17.531 -29.799 1.00 36.11  ? 111 TYR A CZ   1 
ATOM   827  O OH   . TYR A 1 124 ? 20.794  -16.882 -29.668 1.00 32.51  ? 111 TYR A OH   1 
ATOM   828  N N    . TRP A 1 125 ? 25.234  -22.547 -31.088 1.00 33.42  ? 112 TRP A N    1 
ATOM   829  C CA   . TRP A 1 125 ? 24.417  -23.501 -31.817 1.00 34.67  ? 112 TRP A CA   1 
ATOM   830  C C    . TRP A 1 125 ? 24.125  -24.677 -30.896 1.00 38.89  ? 112 TRP A C    1 
ATOM   831  O O    . TRP A 1 125 ? 22.975  -25.076 -30.772 1.00 35.07  ? 112 TRP A O    1 
ATOM   832  C CB   . TRP A 1 125 ? 25.132  -24.020 -33.075 1.00 33.44  ? 112 TRP A CB   1 
ATOM   833  C CG   . TRP A 1 125 ? 24.480  -25.260 -33.636 1.00 31.30  ? 112 TRP A CG   1 
ATOM   834  C CD1  . TRP A 1 125 ? 24.645  -26.556 -33.234 1.00 29.31  ? 112 TRP A CD1  1 
ATOM   835  C CD2  . TRP A 1 125 ? 23.506  -25.288 -34.700 1.00 29.45  ? 112 TRP A CD2  1 
ATOM   836  N NE1  . TRP A 1 125 ? 23.844  -27.393 -33.965 1.00 32.16  ? 112 TRP A NE1  1 
ATOM   837  C CE2  . TRP A 1 125 ? 23.149  -26.646 -34.890 1.00 33.54  ? 112 TRP A CE2  1 
ATOM   838  C CE3  . TRP A 1 125 ? 22.922  -24.310 -35.512 1.00 30.01  ? 112 TRP A CE3  1 
ATOM   839  C CZ2  . TRP A 1 125 ? 22.213  -27.027 -35.852 1.00 31.25  ? 112 TRP A CZ2  1 
ATOM   840  C CZ3  . TRP A 1 125 ? 21.999  -24.695 -36.463 1.00 30.59  ? 112 TRP A CZ3  1 
ATOM   841  C CH2  . TRP A 1 125 ? 21.660  -26.036 -36.637 1.00 30.09  ? 112 TRP A CH2  1 
ATOM   842  N N    . ASP A 1 126 ? 25.181  -25.215 -30.265 1.00 33.71  ? 113 ASP A N    1 
ATOM   843  C CA   . ASP A 1 126 ? 25.043  -26.409 -29.451 1.00 36.76  ? 113 ASP A CA   1 
ATOM   844  C C    . ASP A 1 126 ? 24.097  -26.118 -28.290 1.00 36.58  ? 113 ASP A C    1 
ATOM   845  O O    . ASP A 1 126 ? 23.259  -26.951 -27.962 1.00 35.28  ? 113 ASP A O    1 
ATOM   846  C CB   . ASP A 1 126 ? 26.390  -26.887 -28.921 1.00 43.44  ? 113 ASP A CB   1 
ATOM   847  C CG   . ASP A 1 126 ? 27.245  -27.681 -29.898 1.00 44.56  ? 113 ASP A CG   1 
ATOM   848  O OD1  . ASP A 1 126 ? 26.709  -28.076 -30.974 1.00 40.07  ? 113 ASP A OD1  1 
ATOM   849  O OD2  . ASP A 1 126 ? 28.437  -27.886 -29.570 1.00 42.11  ? 113 ASP A OD2  1 
ATOM   850  N N    . GLU A 1 127 ? 24.282  -24.963 -27.643 1.00 31.42  ? 114 GLU A N    1 
ATOM   851  C CA   . GLU A 1 127 ? 23.530  -24.691 -26.428 1.00 40.98  ? 114 GLU A CA   1 
ATOM   852  C C    . GLU A 1 127 ? 22.065  -24.441 -26.790 1.00 40.89  ? 114 GLU A C    1 
ATOM   853  O O    . GLU A 1 127 ? 21.178  -24.895 -26.068 1.00 37.94  ? 114 GLU A O    1 
ATOM   854  C CB   . GLU A 1 127 ? 24.182  -23.652 -25.510 1.00 48.30  ? 114 GLU A CB   1 
ATOM   855  C CG   . GLU A 1 127 ? 23.767  -22.212 -25.789 1.00 56.21  ? 114 GLU A CG   1 
ATOM   856  C CD   . GLU A 1 127 ? 22.450  -21.758 -25.173 1.00 64.58  ? 114 GLU A CD   1 
ATOM   857  O OE1  . GLU A 1 127 ? 21.982  -20.662 -25.543 1.00 71.78  ? 114 GLU A OE1  1 
ATOM   858  O OE2  . GLU A 1 127 ? 21.893  -22.476 -24.320 1.00 71.35  ? 114 GLU A OE2  1 
ATOM   859  N N    . ARG A 1 128 ? 21.824  -23.757 -27.926 1.00 36.87  ? 115 ARG A N    1 
ATOM   860  C CA   . ARG A 1 128 ? 20.479  -23.451 -28.395 1.00 36.35  ? 115 ARG A CA   1 
ATOM   861  C C    . ARG A 1 128 ? 19.755  -24.753 -28.735 1.00 37.14  ? 115 ARG A C    1 
ATOM   862  O O    . ARG A 1 128 ? 18.568  -24.892 -28.431 1.00 36.27  ? 115 ARG A O    1 
ATOM   863  C CB   . ARG A 1 128 ? 20.540  -22.485 -29.582 1.00 36.65  ? 115 ARG A CB   1 
ATOM   864  C CG   . ARG A 1 128 ? 19.741  -21.195 -29.568 1.00 41.09  ? 115 ARG A CG   1 
ATOM   865  C CD   . ARG A 1 128 ? 20.249  -20.150 -28.615 1.00 43.76  ? 115 ARG A CD   1 
ATOM   866  N NE   . ARG A 1 128 ? 19.836  -20.288 -27.215 1.00 45.34  ? 115 ARG A NE   1 
ATOM   867  C CZ   . ARG A 1 128 ? 19.100  -19.344 -26.631 1.00 58.31  ? 115 ARG A CZ   1 
ATOM   868  N NH1  . ARG A 1 128 ? 19.112  -19.195 -25.317 1.00 64.26  ? 115 ARG A NH1  1 
ATOM   869  N NH2  . ARG A 1 128 ? 18.419  -18.478 -27.365 1.00 58.77  ? 115 ARG A NH2  1 
ATOM   870  N N    . MET A 1 129 ? 20.503  -25.737 -29.271 1.00 34.92  ? 116 MET A N    1 
ATOM   871  C CA   . MET A 1 129 ? 19.917  -27.018 -29.635 1.00 32.10  ? 116 MET A CA   1 
ATOM   872  C C    . MET A 1 129 ? 19.595  -27.810 -28.383 1.00 33.92  ? 116 MET A C    1 
ATOM   873  O O    . MET A 1 129 ? 18.605  -28.541 -28.357 1.00 34.93  ? 116 MET A O    1 
ATOM   874  C CB   . MET A 1 129 ? 20.818  -27.879 -30.543 1.00 33.67  ? 116 MET A CB   1 
ATOM   875  C CG   . MET A 1 129 ? 20.750  -27.497 -32.014 1.00 36.66  ? 116 MET A CG   1 
ATOM   876  S SD   . MET A 1 129 ? 19.108  -27.489 -32.783 1.00 47.72  ? 116 MET A SD   1 
ATOM   877  C CE   . MET A 1 129 ? 19.441  -25.927 -33.572 1.00 31.75  ? 116 MET A CE   1 
ATOM   878  N N    . GLN A 1 130 ? 20.443  -27.661 -27.353 1.00 32.43  ? 117 GLN A N    1 
ATOM   879  C CA   . GLN A 1 130 ? 20.248  -28.371 -26.103 1.00 31.70  ? 117 GLN A CA   1 
ATOM   880  C C    . GLN A 1 130 ? 19.046  -27.814 -25.347 1.00 30.19  ? 117 GLN A C    1 
ATOM   881  O O    . GLN A 1 130 ? 18.315  -28.570 -24.715 1.00 28.74  ? 117 GLN A O    1 
ATOM   882  C CB   . GLN A 1 130 ? 21.538  -28.373 -25.281 1.00 37.43  ? 117 GLN A CB   1 
ATOM   883  C CG   . GLN A 1 130 ? 22.611  -29.214 -25.962 1.00 52.05  ? 117 GLN A CG   1 
ATOM   884  C CD   . GLN A 1 130 ? 24.023  -28.944 -25.492 1.00 53.64  ? 117 GLN A CD   1 
ATOM   885  O OE1  . GLN A 1 130 ? 24.260  -28.237 -24.506 1.00 44.96  ? 117 GLN A OE1  1 
ATOM   886  N NE2  . GLN A 1 130 ? 24.969  -29.523 -26.225 1.00 52.72  ? 117 GLN A NE2  1 
ATOM   887  N N    . THR A 1 131 ? 18.864  -26.489 -25.418 1.00 30.94  ? 118 THR A N    1 
ATOM   888  C CA   . THR A 1 131 ? 17.781  -25.750 -24.763 1.00 30.99  ? 118 THR A CA   1 
ATOM   889  C C    . THR A 1 131 ? 16.425  -25.930 -25.452 1.00 29.06  ? 118 THR A C    1 
ATOM   890  O O    . THR A 1 131 ? 15.372  -25.823 -24.783 1.00 28.84  ? 118 THR A O    1 
ATOM   891  C CB   . THR A 1 131 ? 18.215  -24.285 -24.773 1.00 33.59  ? 118 THR A CB   1 
ATOM   892  O OG1  . THR A 1 131 ? 18.857  -24.148 -23.510 1.00 41.69  ? 118 THR A OG1  1 
ATOM   893  C CG2  . THR A 1 131 ? 17.074  -23.294 -24.846 1.00 40.51  ? 118 THR A CG2  1 
ATOM   894  N N    . ASN A 1 132 ? 16.448  -26.148 -26.778 1.00 29.75  ? 119 ASN A N    1 
ATOM   895  C CA   . ASN A 1 132 ? 15.243  -26.144 -27.610 1.00 25.79  ? 119 ASN A CA   1 
ATOM   896  C C    . ASN A 1 132 ? 14.845  -27.541 -28.087 1.00 26.02  ? 119 ASN A C    1 
ATOM   897  O O    . ASN A 1 132 ? 13.678  -27.747 -28.406 1.00 25.68  ? 119 ASN A O    1 
ATOM   898  C CB   . ASN A 1 132 ? 15.391  -25.194 -28.788 1.00 25.51  ? 119 ASN A CB   1 
ATOM   899  C CG   . ASN A 1 132 ? 15.255  -23.739 -28.377 1.00 32.13  ? 119 ASN A CG   1 
ATOM   900  O OD1  . ASN A 1 132 ? 14.191  -23.300 -27.925 1.00 33.61  ? 119 ASN A OD1  1 
ATOM   901  N ND2  . ASN A 1 132 ? 16.266  -22.945 -28.663 1.00 32.53  ? 119 ASN A ND2  1 
ATOM   902  N N    . LEU A 1 133 ? 15.785  -28.499 -28.172 1.00 23.72  ? 120 LEU A N    1 
ATOM   903  C CA   . LEU A 1 133 ? 15.474  -29.772 -28.807 1.00 24.32  ? 120 LEU A CA   1 
ATOM   904  C C    . LEU A 1 133 ? 15.797  -30.964 -27.922 1.00 25.12  ? 120 LEU A C    1 
ATOM   905  O O    . LEU A 1 133 ? 14.972  -31.852 -27.766 1.00 25.25  ? 120 LEU A O    1 
ATOM   906  C CB   . LEU A 1 133 ? 16.195  -29.904 -30.160 1.00 29.61  ? 120 LEU A CB   1 
ATOM   907  C CG   . LEU A 1 133 ? 16.038  -31.253 -30.864 1.00 33.31  ? 120 LEU A CG   1 
ATOM   908  C CD1  . LEU A 1 133 ? 14.569  -31.483 -31.264 1.00 30.42  ? 120 LEU A CD1  1 
ATOM   909  C CD2  . LEU A 1 133 ? 16.946  -31.371 -32.083 1.00 36.55  ? 120 LEU A CD2  1 
ATOM   910  N N    . ARG A 1 134 ? 17.033  -31.026 -27.400 1.00 30.63  ? 121 ARG A N    1 
ATOM   911  C CA   . ARG A 1 134 ? 17.580  -32.275 -26.881 1.00 30.23  ? 121 ARG A CA   1 
ATOM   912  C C    . ARG A 1 134 ? 16.729  -32.837 -25.745 1.00 26.65  ? 121 ARG A C    1 
ATOM   913  O O    . ARG A 1 134 ? 16.531  -34.056 -25.652 1.00 28.45  ? 121 ARG A O    1 
ATOM   914  C CB   . ARG A 1 134 ? 19.018  -32.092 -26.379 1.00 33.87  ? 121 ARG A CB   1 
ATOM   915  C CG   . ARG A 1 134 ? 19.694  -33.404 -26.010 1.00 35.06  ? 121 ARG A CG   1 
ATOM   916  C CD   . ARG A 1 134 ? 21.167  -33.222 -25.672 1.00 33.01  ? 121 ARG A CD   1 
ATOM   917  N NE   . ARG A 1 134 ? 21.374  -32.436 -24.448 1.00 34.56  ? 121 ARG A NE   1 
ATOM   918  C CZ   . ARG A 1 134 ? 22.582  -32.096 -23.944 1.00 39.18  ? 121 ARG A CZ   1 
ATOM   919  N NH1  . ARG A 1 134 ? 22.651  -31.296 -22.905 1.00 33.89  ? 121 ARG A NH1  1 
ATOM   920  N NH2  . ARG A 1 134 ? 23.716  -32.510 -24.500 1.00 33.39  ? 121 ARG A NH2  1 
ATOM   921  N N    . HIS A 1 135 ? 16.262  -31.937 -24.877 1.00 26.60  ? 122 HIS A N    1 
ATOM   922  C CA   . HIS A 1 135 ? 15.534  -32.294 -23.675 1.00 28.99  ? 122 HIS A CA   1 
ATOM   923  C C    . HIS A 1 135 ? 14.219  -32.962 -24.039 1.00 29.83  ? 122 HIS A C    1 
ATOM   924  O O    . HIS A 1 135 ? 13.804  -33.911 -23.371 1.00 30.03  ? 122 HIS A O    1 
ATOM   925  C CB   . HIS A 1 135 ? 15.323  -31.091 -22.740 1.00 30.50  ? 122 HIS A CB   1 
ATOM   926  C CG   . HIS A 1 135 ? 14.584  -29.942 -23.333 1.00 29.42  ? 122 HIS A CG   1 
ATOM   927  N ND1  . HIS A 1 135 ? 13.208  -29.902 -23.400 1.00 30.19  ? 122 HIS A ND1  1 
ATOM   928  C CD2  . HIS A 1 135 ? 15.018  -28.792 -23.906 1.00 30.19  ? 122 HIS A CD2  1 
ATOM   929  C CE1  . HIS A 1 135 ? 12.830  -28.734 -23.947 1.00 31.18  ? 122 HIS A CE1  1 
ATOM   930  N NE2  . HIS A 1 135 ? 13.920  -28.046 -24.246 1.00 29.33  ? 122 HIS A NE2  1 
ATOM   931  N N    . ALA A 1 136 ? 13.596  -32.490 -25.127 1.00 28.71  ? 123 ALA A N    1 
ATOM   932  C CA   . ALA A 1 136 ? 12.332  -33.083 -25.509 1.00 25.10  ? 123 ALA A CA   1 
ATOM   933  C C    . ALA A 1 136 ? 12.515  -34.582 -25.798 1.00 26.65  ? 123 ALA A C    1 
ATOM   934  O O    . ALA A 1 136 ? 11.642  -35.388 -25.487 1.00 30.59  ? 123 ALA A O    1 
ATOM   935  C CB   . ALA A 1 136 ? 11.693  -32.311 -26.666 1.00 24.36  ? 123 ALA A CB   1 
ATOM   936  N N    . PHE A 1 137 ? 13.672  -34.976 -26.360 1.00 28.92  ? 124 PHE A N    1 
ATOM   937  C CA   . PHE A 1 137 ? 13.848  -36.403 -26.657 1.00 27.04  ? 124 PHE A CA   1 
ATOM   938  C C    . PHE A 1 137 ? 14.059  -37.179 -25.351 1.00 23.44  ? 124 PHE A C    1 
ATOM   939  O O    . PHE A 1 137 ? 13.478  -38.223 -25.124 1.00 29.19  ? 124 PHE A O    1 
ATOM   940  C CB   . PHE A 1 137 ? 14.948  -36.771 -27.668 1.00 30.40  ? 124 PHE A CB   1 
ATOM   941  C CG   . PHE A 1 137 ? 15.342  -38.251 -27.629 1.00 31.94  ? 124 PHE A CG   1 
ATOM   942  C CD1  . PHE A 1 137 ? 14.538  -39.221 -28.215 1.00 35.35  ? 124 PHE A CD1  1 
ATOM   943  C CD2  . PHE A 1 137 ? 16.475  -38.683 -26.943 1.00 33.23  ? 124 PHE A CD2  1 
ATOM   944  C CE1  . PHE A 1 137 ? 14.852  -40.578 -28.140 1.00 34.26  ? 124 PHE A CE1  1 
ATOM   945  C CE2  . PHE A 1 137 ? 16.794  -40.035 -26.883 1.00 29.30  ? 124 PHE A CE2  1 
ATOM   946  C CZ   . PHE A 1 137 ? 15.985  -40.975 -27.486 1.00 30.13  ? 124 PHE A CZ   1 
ATOM   947  N N    . PHE A 1 138 ? 14.926  -36.674 -24.492 1.00 26.30  ? 125 PHE A N    1 
ATOM   948  C CA   . PHE A 1 138 ? 15.291  -37.397 -23.277 1.00 28.39  ? 125 PHE A CA   1 
ATOM   949  C C    . PHE A 1 138 ? 14.133  -37.450 -22.282 1.00 32.53  ? 125 PHE A C    1 
ATOM   950  O O    . PHE A 1 138 ? 13.903  -38.502 -21.663 1.00 29.31  ? 125 PHE A O    1 
ATOM   951  C CB   . PHE A 1 138 ? 16.595  -36.863 -22.670 1.00 27.88  ? 125 PHE A CB   1 
ATOM   952  C CG   . PHE A 1 138 ? 17.781  -37.321 -23.505 1.00 34.53  ? 125 PHE A CG   1 
ATOM   953  C CD1  . PHE A 1 138 ? 18.169  -38.663 -23.464 1.00 30.77  ? 125 PHE A CD1  1 
ATOM   954  C CD2  . PHE A 1 138 ? 18.457  -36.436 -24.352 1.00 31.12  ? 125 PHE A CD2  1 
ATOM   955  C CE1  . PHE A 1 138 ? 19.240  -39.103 -24.228 1.00 30.77  ? 125 PHE A CE1  1 
ATOM   956  C CE2  . PHE A 1 138 ? 19.539  -36.869 -25.106 1.00 33.87  ? 125 PHE A CE2  1 
ATOM   957  C CZ   . PHE A 1 138 ? 19.924  -38.206 -25.040 1.00 32.77  ? 125 PHE A CZ   1 
ATOM   958  N N    . ALA A 1 139 ? 13.335  -36.363 -22.230 1.00 28.93  ? 126 ALA A N    1 
ATOM   959  C CA   . ALA A 1 139 ? 12.150  -36.389 -21.391 1.00 25.20  ? 126 ALA A CA   1 
ATOM   960  C C    . ALA A 1 139 ? 11.220  -37.487 -21.865 1.00 26.88  ? 126 ALA A C    1 
ATOM   961  O O    . ALA A 1 139 ? 10.674  -38.239 -21.048 1.00 27.17  ? 126 ALA A O    1 
ATOM   962  C CB   . ALA A 1 139 ? 11.478  -35.027 -21.344 1.00 23.12  ? 126 ALA A CB   1 
ATOM   963  N N    . ALA A 1 140 ? 11.066  -37.595 -23.196 1.00 29.68  ? 127 ALA A N    1 
ATOM   964  C CA   . ALA A 1 140 ? 10.242  -38.649 -23.784 1.00 28.53  ? 127 ALA A CA   1 
ATOM   965  C C    . ALA A 1 140 ? 10.788  -40.021 -23.383 1.00 27.26  ? 127 ALA A C    1 
ATOM   966  O O    . ALA A 1 140 ? 10.048  -40.917 -22.967 1.00 30.61  ? 127 ALA A O    1 
ATOM   967  C CB   . ALA A 1 140 ? 10.162  -38.493 -25.302 1.00 27.64  ? 127 ALA A CB   1 
ATOM   968  N N    . GLN A 1 141 ? 12.102  -40.180 -23.519 1.00 35.19  ? 128 GLN A N    1 
ATOM   969  C CA   . GLN A 1 141 ? 12.740  -41.458 -23.234 1.00 39.34  ? 128 GLN A CA   1 
ATOM   970  C C    . GLN A 1 141 ? 12.547  -41.843 -21.760 1.00 43.40  ? 128 GLN A C    1 
ATOM   971  O O    . GLN A 1 141 ? 12.379  -43.025 -21.445 1.00 33.83  ? 128 GLN A O    1 
ATOM   972  C CB   . GLN A 1 141 ? 14.215  -41.390 -23.630 1.00 39.56  ? 128 GLN A CB   1 
ATOM   973  C CG   . GLN A 1 141 ? 14.936  -42.726 -23.466 1.00 40.11  ? 128 GLN A CG   1 
ATOM   974  C CD   . GLN A 1 141 ? 16.427  -42.549 -23.405 1.00 38.18  ? 128 GLN A CD   1 
ATOM   975  O OE1  . GLN A 1 141 ? 16.944  -41.690 -22.680 1.00 43.59  ? 128 GLN A OE1  1 
ATOM   976  N NE2  . GLN A 1 141 ? 17.119  -43.277 -24.271 1.00 41.88  ? 128 GLN A NE2  1 
ATOM   977  N N    . ALA A 1 142 ? 12.541  -40.838 -20.869 1.00 38.41  ? 129 ALA A N    1 
ATOM   978  C CA   . ALA A 1 142 ? 12.418  -41.079 -19.433 1.00 36.99  ? 129 ALA A CA   1 
ATOM   979  C C    . ALA A 1 142 ? 10.988  -41.488 -19.059 1.00 34.43  ? 129 ALA A C    1 
ATOM   980  O O    . ALA A 1 142 ? 10.776  -42.415 -18.281 1.00 32.18  ? 129 ALA A O    1 
ATOM   981  C CB   . ALA A 1 142 ? 12.921  -39.878 -18.659 1.00 29.95  ? 129 ALA A CB   1 
ATOM   982  N N    . VAL A 1 143 ? 9.981   -40.850 -19.669 1.00 29.90  ? 130 VAL A N    1 
ATOM   983  C CA   . VAL A 1 143 ? 8.611   -41.139 -19.295 1.00 29.09  ? 130 VAL A CA   1 
ATOM   984  C C    . VAL A 1 143 ? 8.150   -42.456 -19.904 1.00 29.58  ? 130 VAL A C    1 
ATOM   985  O O    . VAL A 1 143 ? 7.283   -43.113 -19.341 1.00 33.01  ? 130 VAL A O    1 
ATOM   986  C CB   . VAL A 1 143 ? 7.626   -39.979 -19.567 1.00 30.00  ? 130 VAL A CB   1 
ATOM   987  C CG1  . VAL A 1 143 ? 7.995   -38.789 -18.687 1.00 25.02  ? 130 VAL A CG1  1 
ATOM   988  C CG2  . VAL A 1 143 ? 7.525   -39.616 -21.060 1.00 24.31  ? 130 VAL A CG2  1 
ATOM   989  N N    . ALA A 1 144 ? 8.754   -42.844 -21.037 1.00 32.90  ? 131 ALA A N    1 
ATOM   990  C CA   . ALA A 1 144 ? 8.241   -43.927 -21.862 1.00 33.40  ? 131 ALA A CA   1 
ATOM   991  C C    . ALA A 1 144 ? 8.095   -45.234 -21.075 1.00 34.41  ? 131 ALA A C    1 
ATOM   992  O O    . ALA A 1 144 ? 7.035   -45.852 -21.118 1.00 32.42  ? 131 ALA A O    1 
ATOM   993  C CB   . ALA A 1 144 ? 9.076   -44.123 -23.105 1.00 35.02  ? 131 ALA A CB   1 
ATOM   994  N N    . PRO A 1 145 ? 9.110   -45.716 -20.324 1.00 38.12  ? 132 PRO A N    1 
ATOM   995  C CA   . PRO A 1 145 ? 9.027   -47.058 -19.735 1.00 40.31  ? 132 PRO A CA   1 
ATOM   996  C C    . PRO A 1 145 ? 7.846   -47.231 -18.792 1.00 38.32  ? 132 PRO A C    1 
ATOM   997  O O    . PRO A 1 145 ? 7.139   -48.232 -18.870 1.00 45.37  ? 132 PRO A O    1 
ATOM   998  C CB   . PRO A 1 145 ? 10.395  -47.266 -19.093 1.00 39.60  ? 132 PRO A CB   1 
ATOM   999  C CG   . PRO A 1 145 ? 11.290  -46.279 -19.821 1.00 36.32  ? 132 PRO A CG   1 
ATOM   1000 C CD   . PRO A 1 145 ? 10.409  -45.079 -20.074 1.00 38.72  ? 132 PRO A CD   1 
ATOM   1001 N N    . GLY A 1 146 ? 7.617   -46.206 -17.948 1.00 39.04  ? 133 GLY A N    1 
ATOM   1002 C CA   . GLY A 1 146 ? 6.508   -46.152 -17.013 1.00 34.28  ? 133 GLY A CA   1 
ATOM   1003 C C    . GLY A 1 146 ? 5.166   -46.113 -17.740 1.00 39.46  ? 133 GLY A C    1 
ATOM   1004 O O    . GLY A 1 146 ? 4.245   -46.859 -17.389 1.00 44.56  ? 133 GLY A O    1 
ATOM   1005 N N    . MET A 1 147 ? 5.073   -45.276 -18.785 1.00 35.70  ? 134 MET A N    1 
ATOM   1006 C CA   . MET A 1 147 ? 3.880   -45.271 -19.625 1.00 32.18  ? 134 MET A CA   1 
ATOM   1007 C C    . MET A 1 147 ? 3.623   -46.676 -20.172 1.00 28.63  ? 134 MET A C    1 
ATOM   1008 O O    . MET A 1 147 ? 2.496   -47.124 -20.238 1.00 38.97  ? 134 MET A O    1 
ATOM   1009 C CB   . MET A 1 147 ? 4.025   -44.288 -20.800 1.00 27.33  ? 134 MET A CB   1 
ATOM   1010 C CG   . MET A 1 147 ? 3.795   -42.860 -20.367 1.00 29.40  ? 134 MET A CG   1 
ATOM   1011 S SD   . MET A 1 147 ? 4.150   -41.680 -21.685 1.00 30.03  ? 134 MET A SD   1 
ATOM   1012 C CE   . MET A 1 147 ? 3.826   -40.166 -20.755 1.00 25.29  ? 134 MET A CE   1 
ATOM   1013 N N    . ALA A 1 148 ? 4.678   -47.343 -20.615 1.00 33.21  ? 135 ALA A N    1 
ATOM   1014 C CA   . ALA A 1 148 ? 4.510   -48.597 -21.342 1.00 33.28  ? 135 ALA A CA   1 
ATOM   1015 C C    . ALA A 1 148 ? 4.041   -49.686 -20.378 1.00 37.90  ? 135 ALA A C    1 
ATOM   1016 O O    . ALA A 1 148 ? 3.225   -50.527 -20.752 1.00 40.36  ? 135 ALA A O    1 
ATOM   1017 C CB   . ALA A 1 148 ? 5.828   -48.966 -21.997 1.00 33.11  ? 135 ALA A CB   1 
ATOM   1018 N N    . ARG A 1 149 ? 4.531   -49.627 -19.129 1.00 44.04  ? 136 ARG A N    1 
ATOM   1019 C CA   . ARG A 1 149 ? 4.154   -50.577 -18.084 1.00 44.24  ? 136 ARG A CA   1 
ATOM   1020 C C    . ARG A 1 149 ? 2.648   -50.496 -17.889 1.00 45.83  ? 136 ARG A C    1 
ATOM   1021 O O    . ARG A 1 149 ? 1.978   -51.517 -17.894 1.00 47.19  ? 136 ARG A O    1 
ATOM   1022 C CB   . ARG A 1 149 ? 4.900   -50.349 -16.759 1.00 49.63  ? 136 ARG A CB   1 
ATOM   1023 N N    . ARG A 1 150 ? 2.120   -49.267 -17.794 1.00 40.09  ? 137 ARG A N    1 
ATOM   1024 C CA   . ARG A 1 150 ? 0.691   -49.064 -17.696 1.00 39.29  ? 137 ARG A CA   1 
ATOM   1025 C C    . ARG A 1 150 ? -0.003  -49.443 -19.015 1.00 43.72  ? 137 ARG A C    1 
ATOM   1026 O O    . ARG A 1 150 ? -1.131  -49.932 -19.009 1.00 44.32  ? 137 ARG A O    1 
ATOM   1027 C CB   . ARG A 1 150 ? 0.433   -47.615 -17.242 1.00 36.64  ? 137 ARG A CB   1 
ATOM   1028 C CG   . ARG A 1 150 ? -1.028  -47.273 -17.035 1.00 38.25  ? 137 ARG A CG   1 
ATOM   1029 C CD   . ARG A 1 150 ? -1.260  -45.881 -16.519 1.00 42.25  ? 137 ARG A CD   1 
ATOM   1030 N NE   . ARG A 1 150 ? -0.549  -44.934 -17.379 1.00 41.75  ? 137 ARG A NE   1 
ATOM   1031 C CZ   . ARG A 1 150 ? 0.330   -44.011 -17.010 1.00 41.83  ? 137 ARG A CZ   1 
ATOM   1032 N NH1  . ARG A 1 150 ? 1.107   -43.446 -17.933 1.00 35.08  ? 137 ARG A NH1  1 
ATOM   1033 N NH2  . ARG A 1 150 ? 0.482   -43.710 -15.723 1.00 39.17  ? 137 ARG A NH2  1 
ATOM   1034 N N    . GLY A 1 151 ? 0.643   -49.193 -20.158 1.00 38.42  ? 138 GLY A N    1 
ATOM   1035 C CA   . GLY A 1 151 ? 0.006   -49.413 -21.450 1.00 39.47  ? 138 GLY A CA   1 
ATOM   1036 C C    . GLY A 1 151 ? -0.713  -48.176 -21.988 1.00 41.37  ? 138 GLY A C    1 
ATOM   1037 O O    . GLY A 1 151 ? -1.599  -48.309 -22.830 1.00 38.27  ? 138 GLY A O    1 
ATOM   1038 N N    . SER A 1 152 ? -0.351  -46.976 -21.495 1.00 45.87  ? 139 SER A N    1 
ATOM   1039 C CA   . SER A 1 152 ? -0.995  -45.751 -21.948 1.00 34.54  ? 139 SER A CA   1 
ATOM   1040 C C    . SER A 1 152 ? -0.138  -44.536 -21.602 1.00 38.10  ? 139 SER A C    1 
ATOM   1041 O O    . SER A 1 152 ? 0.630   -44.559 -20.641 1.00 34.19  ? 139 SER A O    1 
ATOM   1042 C CB   . SER A 1 152 ? -2.374  -45.588 -21.371 1.00 38.78  ? 139 SER A CB   1 
ATOM   1043 O OG   . SER A 1 152 ? -2.304  -45.259 -19.987 1.00 42.96  ? 139 SER A OG   1 
ATOM   1044 N N    . GLY A 1 153 ? -0.335  -43.455 -22.373 1.00 35.86  ? 140 GLY A N    1 
ATOM   1045 C CA   . GLY A 1 153 ? 0.361   -42.208 -22.119 1.00 33.94  ? 140 GLY A CA   1 
ATOM   1046 C C    . GLY A 1 153 ? 0.222   -41.267 -23.307 1.00 34.22  ? 140 GLY A C    1 
ATOM   1047 O O    . GLY A 1 153 ? -0.104  -41.696 -24.398 1.00 32.43  ? 140 GLY A O    1 
ATOM   1048 N N    . ALA A 1 154 ? 0.495   -39.982 -23.074 1.00 33.42  ? 141 ALA A N    1 
ATOM   1049 C CA   . ALA A 1 154 ? 0.386   -38.970 -24.111 1.00 31.07  ? 141 ALA A CA   1 
ATOM   1050 C C    . ALA A 1 154 ? 1.577   -38.042 -23.965 1.00 30.38  ? 141 ALA A C    1 
ATOM   1051 O O    . ALA A 1 154 ? 1.922   -37.665 -22.833 1.00 31.37  ? 141 ALA A O    1 
ATOM   1052 C CB   . ALA A 1 154 ? -0.920  -38.208 -23.969 1.00 27.10  ? 141 ALA A CB   1 
ATOM   1053 N N    . ILE A 1 155 ? 2.170   -37.683 -25.113 1.00 25.35  ? 142 ILE A N    1 
ATOM   1054 C CA   . ILE A 1 155 ? 3.245   -36.712 -25.173 1.00 26.50  ? 142 ILE A CA   1 
ATOM   1055 C C    . ILE A 1 155 ? 2.803   -35.578 -26.100 1.00 24.15  ? 142 ILE A C    1 
ATOM   1056 O O    . ILE A 1 155 ? 2.198   -35.824 -27.128 1.00 26.29  ? 142 ILE A O    1 
ATOM   1057 C CB   . ILE A 1 155 ? 4.567   -37.370 -25.609 1.00 26.86  ? 142 ILE A CB   1 
ATOM   1058 C CG1  . ILE A 1 155 ? 4.968   -38.513 -24.627 1.00 27.18  ? 142 ILE A CG1  1 
ATOM   1059 C CG2  . ILE A 1 155 ? 5.681   -36.325 -25.742 1.00 23.92  ? 142 ILE A CG2  1 
ATOM   1060 C CD1  . ILE A 1 155 ? 6.272   -39.212 -24.937 1.00 26.15  ? 142 ILE A CD1  1 
ATOM   1061 N N    . ILE A 1 156 ? 3.077   -34.341 -25.695 1.00 26.84  ? 143 ILE A N    1 
ATOM   1062 C CA   . ILE A 1 156 ? 2.803   -33.191 -26.536 1.00 24.70  ? 143 ILE A CA   1 
ATOM   1063 C C    . ILE A 1 156 ? 4.103   -32.410 -26.677 1.00 23.00  ? 143 ILE A C    1 
ATOM   1064 O O    . ILE A 1 156 ? 4.624   -31.886 -25.704 1.00 22.99  ? 143 ILE A O    1 
ATOM   1065 C CB   . ILE A 1 156 ? 1.722   -32.296 -25.891 1.00 30.05  ? 143 ILE A CB   1 
ATOM   1066 C CG1  . ILE A 1 156 ? 0.392   -33.047 -25.691 1.00 30.08  ? 143 ILE A CG1  1 
ATOM   1067 C CG2  . ILE A 1 156 ? 1.542   -30.978 -26.689 1.00 22.37  ? 143 ILE A CG2  1 
ATOM   1068 C CD1  . ILE A 1 156 ? -0.563  -32.407 -24.685 1.00 26.18  ? 143 ILE A CD1  1 
ATOM   1069 N N    . ASN A 1 157 ? 4.582   -32.264 -27.923 1.00 24.92  ? 144 ASN A N    1 
ATOM   1070 C CA   . ASN A 1 157 ? 5.787   -31.502 -28.187 1.00 24.40  ? 144 ASN A CA   1 
ATOM   1071 C C    . ASN A 1 157 ? 5.309   -30.138 -28.635 1.00 25.06  ? 144 ASN A C    1 
ATOM   1072 O O    . ASN A 1 157 ? 4.461   -30.063 -29.507 1.00 23.84  ? 144 ASN A O    1 
ATOM   1073 C CB   . ASN A 1 157 ? 6.616   -32.153 -29.311 1.00 29.46  ? 144 ASN A CB   1 
ATOM   1074 C CG   . ASN A 1 157 ? 7.254   -33.468 -28.892 1.00 26.84  ? 144 ASN A CG   1 
ATOM   1075 O OD1  . ASN A 1 157 ? 7.709   -33.596 -27.754 1.00 25.00  ? 144 ASN A OD1  1 
ATOM   1076 N ND2  . ASN A 1 157 ? 7.308   -34.462 -29.763 1.00 31.01  ? 144 ASN A ND2  1 
ATOM   1077 N N    . MET A 1 158 ? 5.802   -29.078 -27.990 1.00 26.13  ? 145 MET A N    1 
ATOM   1078 C CA   . MET A 1 158 ? 5.501   -27.734 -28.457 1.00 26.20  ? 145 MET A CA   1 
ATOM   1079 C C    . MET A 1 158 ? 6.308   -27.464 -29.724 1.00 26.48  ? 145 MET A C    1 
ATOM   1080 O O    . MET A 1 158 ? 7.546   -27.381 -29.683 1.00 25.90  ? 145 MET A O    1 
ATOM   1081 C CB   . MET A 1 158 ? 5.834   -26.695 -27.366 1.00 27.26  ? 145 MET A CB   1 
ATOM   1082 C CG   . MET A 1 158 ? 4.936   -26.834 -26.119 1.00 29.85  ? 145 MET A CG   1 
ATOM   1083 S SD   . MET A 1 158 ? 3.201   -26.526 -26.542 1.00 31.27  ? 145 MET A SD   1 
ATOM   1084 C CE   . MET A 1 158 ? 3.448   -24.801 -26.970 1.00 23.02  ? 145 MET A CE   1 
ATOM   1085 N N    . GLY A 1 159 ? 5.581   -27.299 -30.826 1.00 22.81  ? 146 GLY A N    1 
ATOM   1086 C CA   . GLY A 1 159 ? 6.079   -26.929 -32.138 1.00 21.34  ? 146 GLY A CA   1 
ATOM   1087 C C    . GLY A 1 159 ? 6.050   -25.416 -32.330 1.00 25.20  ? 146 GLY A C    1 
ATOM   1088 O O    . GLY A 1 159 ? 5.903   -24.694 -31.359 1.00 24.75  ? 146 GLY A O    1 
ATOM   1089 N N    . SER A 1 160 ? 6.198   -24.953 -33.579 1.00 26.70  ? 147 SER A N    1 
ATOM   1090 C CA   . SER A 1 160 ? 6.065   -23.530 -33.885 1.00 23.99  ? 147 SER A CA   1 
ATOM   1091 C C    . SER A 1 160 ? 5.763   -23.389 -35.370 1.00 21.58  ? 147 SER A C    1 
ATOM   1092 O O    . SER A 1 160 ? 6.268   -24.182 -36.165 1.00 23.59  ? 147 SER A O    1 
ATOM   1093 C CB   . SER A 1 160 ? 7.297   -22.765 -33.449 1.00 26.76  ? 147 SER A CB   1 
ATOM   1094 O OG   . SER A 1 160 ? 7.246   -21.409 -33.895 1.00 24.60  ? 147 SER A OG   1 
ATOM   1095 N N    . ILE A 1 161 ? 4.951   -22.387 -35.762 1.00 22.17  ? 148 ILE A N    1 
ATOM   1096 C CA   . ILE A 1 161 ? 4.712   -22.153 -37.178 1.00 21.61  ? 148 ILE A CA   1 
ATOM   1097 C C    . ILE A 1 161 ? 5.890   -21.414 -37.813 1.00 24.21  ? 148 ILE A C    1 
ATOM   1098 O O    . ILE A 1 161 ? 5.888   -21.197 -39.028 1.00 22.11  ? 148 ILE A O    1 
ATOM   1099 C CB   . ILE A 1 161 ? 3.410   -21.349 -37.419 1.00 25.30  ? 148 ILE A CB   1 
ATOM   1100 C CG1  . ILE A 1 161 ? 3.533   -19.911 -36.815 1.00 24.80  ? 148 ILE A CG1  1 
ATOM   1101 C CG2  . ILE A 1 161 ? 2.167   -22.086 -36.895 1.00 23.17  ? 148 ILE A CG2  1 
ATOM   1102 C CD1  . ILE A 1 161 ? 2.494   -18.950 -37.342 1.00 20.92  ? 148 ILE A CD1  1 
ATOM   1103 N N    . SER A 1 162 ? 6.855   -20.973 -36.988 1.00 23.82  ? 149 SER A N    1 
ATOM   1104 C CA   . SER A 1 162 ? 7.947   -20.126 -37.465 1.00 24.58  ? 149 SER A CA   1 
ATOM   1105 C C    . SER A 1 162 ? 8.712   -20.793 -38.599 1.00 26.18  ? 149 SER A C    1 
ATOM   1106 O O    . SER A 1 162 ? 9.038   -20.155 -39.598 1.00 25.80  ? 149 SER A O    1 
ATOM   1107 C CB   . SER A 1 162 ? 8.887   -19.713 -36.340 1.00 25.46  ? 149 SER A CB   1 
ATOM   1108 O OG   . SER A 1 162 ? 9.404   -20.838 -35.641 1.00 26.90  ? 149 SER A OG   1 
ATOM   1109 N N    . TRP A 1 163 ? 9.018   -22.081 -38.440 1.00 24.34  ? 150 TRP A N    1 
ATOM   1110 C CA   . TRP A 1 163 ? 9.790   -22.723 -39.486 1.00 22.88  ? 150 TRP A CA   1 
ATOM   1111 C C    . TRP A 1 163 ? 8.905   -22.945 -40.700 1.00 22.53  ? 150 TRP A C    1 
ATOM   1112 O O    . TRP A 1 163 ? 9.389   -22.868 -41.824 1.00 24.50  ? 150 TRP A O    1 
ATOM   1113 C CB   . TRP A 1 163 ? 10.417  -24.028 -38.983 1.00 23.09  ? 150 TRP A CB   1 
ATOM   1114 C CG   . TRP A 1 163 ? 9.421   -25.132 -38.742 1.00 23.25  ? 150 TRP A CG   1 
ATOM   1115 C CD1  . TRP A 1 163 ? 8.831   -25.441 -37.554 1.00 26.30  ? 150 TRP A CD1  1 
ATOM   1116 C CD2  . TRP A 1 163 ? 8.891   -26.072 -39.702 1.00 28.33  ? 150 TRP A CD2  1 
ATOM   1117 N NE1  . TRP A 1 163 ? 8.006   -26.531 -37.697 1.00 28.69  ? 150 TRP A NE1  1 
ATOM   1118 C CE2  . TRP A 1 163 ? 8.021   -26.945 -38.992 1.00 28.07  ? 150 TRP A CE2  1 
ATOM   1119 C CE3  . TRP A 1 163 ? 9.071   -26.285 -41.074 1.00 29.91  ? 150 TRP A CE3  1 
ATOM   1120 C CZ2  . TRP A 1 163 ? 7.308   -27.977 -39.615 1.00 32.43  ? 150 TRP A CZ2  1 
ATOM   1121 C CZ3  . TRP A 1 163 ? 8.379   -27.308 -41.695 1.00 25.94  ? 150 TRP A CZ3  1 
ATOM   1122 C CH2  . TRP A 1 163 ? 7.499   -28.131 -40.980 1.00 31.73  ? 150 TRP A CH2  1 
ATOM   1123 N N    . MET A 1 164 ? 7.612   -23.210 -40.475 1.00 26.57  ? 151 MET A N    1 
ATOM   1124 C CA   . MET A 1 164 ? 6.675   -23.437 -41.588 1.00 25.59  ? 151 MET A CA   1 
ATOM   1125 C C    . MET A 1 164 ? 6.611   -22.200 -42.488 1.00 24.18  ? 151 MET A C    1 
ATOM   1126 O O    . MET A 1 164 ? 6.545   -22.296 -43.716 1.00 24.71  ? 151 MET A O    1 
ATOM   1127 C CB   . MET A 1 164 ? 5.255   -23.734 -41.076 1.00 25.12  ? 151 MET A CB   1 
ATOM   1128 C CG   . MET A 1 164 ? 5.141   -25.125 -40.396 1.00 29.41  ? 151 MET A CG   1 
ATOM   1129 S SD   . MET A 1 164 ? 3.649   -25.216 -39.388 1.00 30.54  ? 151 MET A SD   1 
ATOM   1130 C CE   . MET A 1 164 ? 3.858   -26.891 -38.719 1.00 28.00  ? 151 MET A CE   1 
ATOM   1131 N N    . ARG A 1 165 ? 6.582   -21.035 -41.848 1.00 25.21  ? 152 ARG A N    1 
ATOM   1132 C CA   . ARG A 1 165 ? 6.576   -19.739 -42.508 1.00 25.73  ? 152 ARG A CA   1 
ATOM   1133 C C    . ARG A 1 165 ? 7.986   -19.299 -42.884 1.00 24.36  ? 152 ARG A C    1 
ATOM   1134 O O    . ARG A 1 165 ? 8.141   -18.217 -43.457 1.00 25.94  ? 152 ARG A O    1 
ATOM   1135 C CB   . ARG A 1 165 ? 6.131   -18.716 -41.447 1.00 20.80  ? 152 ARG A CB   1 
ATOM   1136 C CG   . ARG A 1 165 ? 4.640   -18.744 -41.197 1.00 21.64  ? 152 ARG A CG   1 
ATOM   1137 C CD   . ARG A 1 165 ? 4.291   -17.550 -40.246 1.00 23.71  ? 152 ARG A CD   1 
ATOM   1138 N NE   . ARG A 1 165 ? 4.520   -16.320 -41.006 1.00 24.91  ? 152 ARG A NE   1 
ATOM   1139 C CZ   . ARG A 1 165 ? 4.420   -15.110 -40.448 1.00 32.19  ? 152 ARG A CZ   1 
ATOM   1140 N NH1  . ARG A 1 165 ? 4.311   -14.985 -39.134 1.00 25.14  ? 152 ARG A NH1  1 
ATOM   1141 N NH2  . ARG A 1 165 ? 4.449   -14.010 -41.209 1.00 29.79  ? 152 ARG A NH2  1 
ATOM   1142 N N    . GLY A 1 166 ? 8.992   -20.166 -42.660 1.00 22.65  ? 153 GLY A N    1 
ATOM   1143 C CA   . GLY A 1 166 ? 10.376  -19.840 -42.969 1.00 26.00  ? 153 GLY A CA   1 
ATOM   1144 C C    . GLY A 1 166 ? 10.793  -18.471 -42.400 1.00 29.20  ? 153 GLY A C    1 
ATOM   1145 O O    . GLY A 1 166 ? 11.414  -17.670 -43.106 1.00 31.50  ? 153 GLY A O    1 
ATOM   1146 N N    . ARG A 1 167 ? 10.485  -18.229 -41.121 1.00 30.06  ? 154 ARG A N    1 
ATOM   1147 C CA   . ARG A 1 167 ? 10.812  -16.977 -40.446 1.00 33.01  ? 154 ARG A CA   1 
ATOM   1148 C C    . ARG A 1 167 ? 12.323  -16.902 -40.257 1.00 33.59  ? 154 ARG A C    1 
ATOM   1149 O O    . ARG A 1 167 ? 12.938  -17.851 -39.746 1.00 30.33  ? 154 ARG A O    1 
ATOM   1150 C CB   . ARG A 1 167 ? 10.157  -16.790 -39.067 1.00 32.75  ? 154 ARG A CB   1 
ATOM   1151 C CG   . ARG A 1 167 ? 8.634   -16.828 -39.109 1.00 37.69  ? 154 ARG A CG   1 
ATOM   1152 C CD   . ARG A 1 167 ? 8.161   -15.740 -40.059 1.00 42.65  ? 154 ARG A CD   1 
ATOM   1153 N NE   . ARG A 1 167 ? 8.244   -14.396 -39.489 1.00 43.92  ? 154 ARG A NE   1 
ATOM   1154 C CZ   . ARG A 1 167 ? 8.327   -13.266 -40.179 1.00 47.81  ? 154 ARG A CZ   1 
ATOM   1155 N NH1  . ARG A 1 167 ? 8.788   -13.237 -41.421 1.00 52.79  ? 154 ARG A NH1  1 
ATOM   1156 N NH2  . ARG A 1 167 ? 7.985   -12.139 -39.584 1.00 40.76  ? 154 ARG A NH2  1 
ATOM   1157 N N    . PRO A 1 168 ? 12.953  -15.781 -40.690 1.00 27.38  ? 155 PRO A N    1 
ATOM   1158 C CA   . PRO A 1 168 ? 14.382  -15.592 -40.524 1.00 25.41  ? 155 PRO A CA   1 
ATOM   1159 C C    . PRO A 1 168 ? 14.745  -15.091 -39.112 1.00 28.50  ? 155 PRO A C    1 
ATOM   1160 O O    . PRO A 1 168 ? 13.882  -14.644 -38.369 1.00 28.12  ? 155 PRO A O    1 
ATOM   1161 C CB   . PRO A 1 168 ? 14.700  -14.527 -41.594 1.00 26.12  ? 155 PRO A CB   1 
ATOM   1162 C CG   . PRO A 1 168 ? 13.461  -13.625 -41.472 1.00 29.02  ? 155 PRO A CG   1 
ATOM   1163 C CD   . PRO A 1 168 ? 12.285  -14.611 -41.303 1.00 31.44  ? 155 PRO A CD   1 
ATOM   1164 N N    . GLY A 1 169 ? 16.026  -15.181 -38.738 1.00 30.97  ? 156 GLY A N    1 
ATOM   1165 C CA   . GLY A 1 169 ? 16.559  -14.400 -37.627 1.00 33.60  ? 156 GLY A CA   1 
ATOM   1166 C C    . GLY A 1 169 ? 16.600  -15.171 -36.309 1.00 35.64  ? 156 GLY A C    1 
ATOM   1167 O O    . GLY A 1 169 ? 16.736  -14.568 -35.253 1.00 30.70  ? 156 GLY A O    1 
ATOM   1168 N N    . MET A 1 170 ? 16.427  -16.501 -36.367 1.00 33.41  ? 157 MET A N    1 
ATOM   1169 C CA   . MET A 1 170 ? 16.518  -17.339 -35.187 1.00 29.53  ? 157 MET A CA   1 
ATOM   1170 C C    . MET A 1 170 ? 16.683  -18.795 -35.608 1.00 31.09  ? 157 MET A C    1 
ATOM   1171 O O    . MET A 1 170 ? 15.959  -19.667 -35.115 1.00 31.42  ? 157 MET A O    1 
ATOM   1172 C CB   . MET A 1 170 ? 15.313  -17.120 -34.267 1.00 35.91  ? 157 MET A CB   1 
ATOM   1173 C CG   . MET A 1 170 ? 13.968  -17.478 -34.857 1.00 39.76  ? 157 MET A CG   1 
ATOM   1174 S SD   . MET A 1 170 ? 12.562  -17.103 -33.787 1.00 45.75  ? 157 MET A SD   1 
ATOM   1175 C CE   . MET A 1 170 ? 11.344  -16.673 -35.045 1.00 44.44  ? 157 MET A CE   1 
ATOM   1176 N N    . VAL A 1 171 ? 17.720  -19.033 -36.427 1.00 27.65  ? 158 VAL A N    1 
ATOM   1177 C CA   . VAL A 1 171 ? 17.947  -20.289 -37.126 1.00 29.39  ? 158 VAL A CA   1 
ATOM   1178 C C    . VAL A 1 171 ? 17.880  -21.444 -36.131 1.00 32.96  ? 158 VAL A C    1 
ATOM   1179 O O    . VAL A 1 171 ? 17.307  -22.466 -36.444 1.00 28.58  ? 158 VAL A O    1 
ATOM   1180 C CB   . VAL A 1 171 ? 19.207  -20.385 -38.018 1.00 29.65  ? 158 VAL A CB   1 
ATOM   1181 C CG1  . VAL A 1 171 ? 20.512  -20.252 -37.216 1.00 32.42  ? 158 VAL A CG1  1 
ATOM   1182 C CG2  . VAL A 1 171 ? 19.233  -21.677 -38.835 1.00 25.37  ? 158 VAL A CG2  1 
ATOM   1183 N N    . CYS A 1 172 ? 18.506  -21.300 -34.949 1.00 36.84  ? 159 CYS A N    1 
ATOM   1184 C CA   . CYS A 1 172 ? 18.607  -22.440 -34.057 1.00 33.08  ? 159 CYS A CA   1 
ATOM   1185 C C    . CYS A 1 172 ? 17.235  -22.846 -33.515 1.00 36.11  ? 159 CYS A C    1 
ATOM   1186 O O    . CYS A 1 172 ? 16.987  -24.035 -33.345 1.00 32.55  ? 159 CYS A O    1 
ATOM   1187 C CB   . CYS A 1 172 ? 19.555  -22.169 -32.897 1.00 37.04  ? 159 CYS A CB   1 
ATOM   1188 S SG   . CYS A 1 172 ? 21.282  -21.988 -33.416 1.00 34.84  ? 159 CYS A SG   1 
ATOM   1189 N N    . TYR A 1 173 ? 16.374  -21.850 -33.225 1.00 33.17  ? 160 TYR A N    1 
ATOM   1190 C CA   . TYR A 1 173 ? 15.048  -22.038 -32.660 1.00 29.79  ? 160 TYR A CA   1 
ATOM   1191 C C    . TYR A 1 173 ? 14.136  -22.664 -33.705 1.00 27.77  ? 160 TYR A C    1 
ATOM   1192 O O    . TYR A 1 173 ? 13.479  -23.666 -33.433 1.00 33.47  ? 160 TYR A O    1 
ATOM   1193 C CB   . TYR A 1 173 ? 14.447  -20.708 -32.164 1.00 30.59  ? 160 TYR A CB   1 
ATOM   1194 C CG   . TYR A 1 173 ? 13.004  -20.865 -31.681 1.00 32.81  ? 160 TYR A CG   1 
ATOM   1195 C CD1  . TYR A 1 173 ? 12.705  -21.326 -30.391 1.00 26.38  ? 160 TYR A CD1  1 
ATOM   1196 C CD2  . TYR A 1 173 ? 11.947  -20.550 -32.526 1.00 27.71  ? 160 TYR A CD2  1 
ATOM   1197 C CE1  . TYR A 1 173 ? 11.394  -21.463 -29.959 1.00 28.37  ? 160 TYR A CE1  1 
ATOM   1198 C CE2  . TYR A 1 173 ? 10.633  -20.719 -32.113 1.00 32.23  ? 160 TYR A CE2  1 
ATOM   1199 C CZ   . TYR A 1 173 ? 10.357  -21.165 -30.833 1.00 30.19  ? 160 TYR A CZ   1 
ATOM   1200 O OH   . TYR A 1 173 ? 9.057   -21.330 -30.460 1.00 38.07  ? 160 TYR A OH   1 
ATOM   1201 N N    . THR A 1 174 ? 14.130  -22.087 -34.915 1.00 28.68  ? 161 THR A N    1 
ATOM   1202 C CA   . THR A 1 174 ? 13.250  -22.568 -35.986 1.00 27.61  ? 161 THR A CA   1 
ATOM   1203 C C    . THR A 1 174 ? 13.695  -23.971 -36.407 1.00 26.01  ? 161 THR A C    1 
ATOM   1204 O O    . THR A 1 174 ? 12.866  -24.825 -36.642 1.00 27.28  ? 161 THR A O    1 
ATOM   1205 C CB   . THR A 1 174 ? 13.210  -21.576 -37.146 1.00 29.28  ? 161 THR A CB   1 
ATOM   1206 O OG1  . THR A 1 174 ? 14.540  -21.307 -37.580 1.00 24.47  ? 161 THR A OG1  1 
ATOM   1207 C CG2  . THR A 1 174 ? 12.533  -20.266 -36.787 1.00 27.00  ? 161 THR A CG2  1 
ATOM   1208 N N    . THR A 1 175 ? 15.009  -24.249 -36.318 1.00 25.28  ? 162 THR A N    1 
ATOM   1209 C CA   . THR A 1 175 ? 15.531  -25.528 -36.785 1.00 26.98  ? 162 THR A CA   1 
ATOM   1210 C C    . THR A 1 175 ? 15.163  -26.622 -35.783 1.00 25.40  ? 162 THR A C    1 
ATOM   1211 O O    . THR A 1 175 ? 14.818  -27.741 -36.164 1.00 27.44  ? 162 THR A O    1 
ATOM   1212 C CB   . THR A 1 175 ? 17.039  -25.459 -37.060 1.00 25.41  ? 162 THR A CB   1 
ATOM   1213 O OG1  . THR A 1 175 ? 17.288  -24.485 -38.075 1.00 25.77  ? 162 THR A OG1  1 
ATOM   1214 C CG2  . THR A 1 175 ? 17.537  -26.784 -37.632 1.00 21.74  ? 162 THR A CG2  1 
ATOM   1215 N N    . ALA A 1 176 ? 15.253  -26.286 -34.486 1.00 30.90  ? 163 ALA A N    1 
ATOM   1216 C CA   . ALA A 1 176 ? 14.856  -27.173 -33.388 1.00 28.31  ? 163 ALA A CA   1 
ATOM   1217 C C    . ALA A 1 176 ? 13.377  -27.511 -33.494 1.00 25.22  ? 163 ALA A C    1 
ATOM   1218 O O    . ALA A 1 176 ? 12.964  -28.671 -33.323 1.00 24.18  ? 163 ALA A O    1 
ATOM   1219 C CB   . ALA A 1 176 ? 15.158  -26.537 -32.028 1.00 24.92  ? 163 ALA A CB   1 
ATOM   1220 N N    . LYS A 1 177 ? 12.559  -26.463 -33.710 1.00 24.35  ? 164 LYS A N    1 
ATOM   1221 C CA   . LYS A 1 177 ? 11.127  -26.644 -33.883 1.00 24.00  ? 164 LYS A CA   1 
ATOM   1222 C C    . LYS A 1 177 ? 10.823  -27.563 -35.072 1.00 24.39  ? 164 LYS A C    1 
ATOM   1223 O O    . LYS A 1 177 ? 9.937   -28.398 -34.974 1.00 26.74  ? 164 LYS A O    1 
ATOM   1224 C CB   . LYS A 1 177 ? 10.405  -25.284 -33.894 1.00 24.88  ? 164 LYS A CB   1 
ATOM   1225 C CG   . LYS A 1 177 ? 10.330  -24.613 -32.509 1.00 27.26  ? 164 LYS A CG   1 
ATOM   1226 C CD   . LYS A 1 177 ? 9.966   -25.447 -31.264 1.00 23.21  ? 164 LYS A CD   1 
ATOM   1227 C CE   . LYS A 1 177 ? 9.809   -24.749 -29.928 1.00 29.62  ? 164 LYS A CE   1 
ATOM   1228 N NZ   . LYS A 1 177 ? 9.434   -25.649 -28.809 1.00 27.36  ? 164 LYS A NZ   1 
ATOM   1229 N N    . ALA A 1 178 ? 11.507  -27.375 -36.213 1.00 24.48  ? 165 ALA A N    1 
ATOM   1230 C CA   . ALA A 1 178 ? 11.327  -28.259 -37.362 1.00 26.02  ? 165 ALA A CA   1 
ATOM   1231 C C    . ALA A 1 178 ? 11.727  -29.702 -37.003 1.00 27.05  ? 165 ALA A C    1 
ATOM   1232 O O    . ALA A 1 178 ? 11.133  -30.649 -37.493 1.00 26.17  ? 165 ALA A O    1 
ATOM   1233 C CB   . ALA A 1 178 ? 12.149  -27.759 -38.521 1.00 23.94  ? 165 ALA A CB   1 
ATOM   1234 N N    . ALA A 1 179 ? 12.777  -29.850 -36.186 1.00 25.31  ? 166 ALA A N    1 
ATOM   1235 C CA   . ALA A 1 179 ? 13.257  -31.148 -35.723 1.00 25.42  ? 166 ALA A CA   1 
ATOM   1236 C C    . ALA A 1 179 ? 12.182  -31.881 -34.923 1.00 24.82  ? 166 ALA A C    1 
ATOM   1237 O O    . ALA A 1 179 ? 11.934  -33.064 -35.143 1.00 23.59  ? 166 ALA A O    1 
ATOM   1238 C CB   . ALA A 1 179 ? 14.528  -30.933 -34.890 1.00 25.88  ? 166 ALA A CB   1 
ATOM   1239 N N    . LEU A 1 180 ? 11.474  -31.144 -34.054 1.00 26.12  ? 167 LEU A N    1 
ATOM   1240 C CA   . LEU A 1 180 ? 10.394  -31.686 -33.235 1.00 31.19  ? 167 LEU A CA   1 
ATOM   1241 C C    . LEU A 1 180 ? 9.234   -32.174 -34.102 1.00 27.68  ? 167 LEU A C    1 
ATOM   1242 O O    . LEU A 1 180 ? 8.533   -33.119 -33.756 1.00 25.37  ? 167 LEU A O    1 
ATOM   1243 C CB   . LEU A 1 180 ? 9.924   -30.641 -32.218 1.00 31.66  ? 167 LEU A CB   1 
ATOM   1244 C CG   . LEU A 1 180 ? 10.855  -30.406 -31.022 1.00 33.23  ? 167 LEU A CG   1 
ATOM   1245 C CD1  . LEU A 1 180 ? 10.333  -29.299 -30.128 1.00 30.19  ? 167 LEU A CD1  1 
ATOM   1246 C CD2  . LEU A 1 180 ? 10.965  -31.692 -30.196 1.00 34.08  ? 167 LEU A CD2  1 
ATOM   1247 N N    . ASN A 1 181 ? 9.017   -31.497 -35.225 1.00 27.20  ? 168 ASN A N    1 
ATOM   1248 C CA   . ASN A 1 181 ? 8.009   -31.900 -36.198 1.00 24.51  ? 168 ASN A CA   1 
ATOM   1249 C C    . ASN A 1 181 ? 8.287   -33.329 -36.650 1.00 25.31  ? 168 ASN A C    1 
ATOM   1250 O O    . ASN A 1 181 ? 7.379   -34.150 -36.679 1.00 27.91  ? 168 ASN A O    1 
ATOM   1251 C CB   . ASN A 1 181 ? 8.004   -30.958 -37.390 1.00 28.42  ? 168 ASN A CB   1 
ATOM   1252 C CG   . ASN A 1 181 ? 6.979   -31.333 -38.424 1.00 27.38  ? 168 ASN A CG   1 
ATOM   1253 O OD1  . ASN A 1 181 ? 5.814   -31.529 -38.084 1.00 31.40  ? 168 ASN A OD1  1 
ATOM   1254 N ND2  . ASN A 1 181 ? 7.390   -31.414 -39.680 1.00 28.18  ? 168 ASN A ND2  1 
ATOM   1255 N N    . GLY A 1 182 ? 9.548   -33.625 -36.973 1.00 24.00  ? 169 GLY A N    1 
ATOM   1256 C CA   . GLY A 1 182 ? 9.899   -34.991 -37.361 1.00 25.82  ? 169 GLY A CA   1 
ATOM   1257 C C    . GLY A 1 182 ? 9.876   -35.957 -36.169 1.00 29.46  ? 169 GLY A C    1 
ATOM   1258 O O    . GLY A 1 182 ? 9.375   -37.061 -36.289 1.00 30.88  ? 169 GLY A O    1 
ATOM   1259 N N    . MET A 1 183 ? 10.408  -35.527 -35.019 1.00 30.41  ? 170 MET A N    1 
ATOM   1260 C CA   . MET A 1 183 ? 10.535  -36.416 -33.878 1.00 31.05  ? 170 MET A CA   1 
ATOM   1261 C C    . MET A 1 183 ? 9.149   -36.878 -33.429 1.00 33.10  ? 170 MET A C    1 
ATOM   1262 O O    . MET A 1 183 ? 8.953   -38.054 -33.067 1.00 29.47  ? 170 MET A O    1 
ATOM   1263 C CB   . MET A 1 183 ? 11.328  -35.729 -32.754 1.00 34.69  ? 170 MET A CB   1 
ATOM   1264 C CG   . MET A 1 183 ? 11.741  -36.690 -31.632 1.00 37.89  ? 170 MET A CG   1 
ATOM   1265 S SD   . MET A 1 183 ? 12.337  -35.786 -30.193 1.00 45.15  ? 170 MET A SD   1 
ATOM   1266 C CE   . MET A 1 183 ? 10.890  -35.185 -29.326 1.00 35.10  ? 170 MET A CE   1 
ATOM   1267 N N    . THR A 1 184 ? 8.169   -35.949 -33.457 1.00 29.01  ? 171 THR A N    1 
ATOM   1268 C CA   . THR A 1 184 ? 6.791   -36.346 -33.218 1.00 25.86  ? 171 THR A CA   1 
ATOM   1269 C C    . THR A 1 184 ? 6.389   -37.581 -34.031 1.00 29.55  ? 171 THR A C    1 
ATOM   1270 O O    . THR A 1 184 ? 5.813   -38.530 -33.474 1.00 34.74  ? 171 THR A O    1 
ATOM   1271 C CB   . THR A 1 184 ? 5.839   -35.159 -33.411 1.00 27.71  ? 171 THR A CB   1 
ATOM   1272 O OG1  . THR A 1 184 ? 6.184   -34.138 -32.458 1.00 26.95  ? 171 THR A OG1  1 
ATOM   1273 C CG2  . THR A 1 184 ? 4.389   -35.572 -33.242 1.00 23.64  ? 171 THR A CG2  1 
ATOM   1274 N N    . ARG A 1 185 ? 6.603   -37.550 -35.354 1.00 30.13  ? 172 ARG A N    1 
ATOM   1275 C CA   . ARG A 1 185 ? 6.125   -38.606 -36.232 1.00 30.27  ? 172 ARG A CA   1 
ATOM   1276 C C    . ARG A 1 185 ? 6.828   -39.940 -35.927 1.00 28.41  ? 172 ARG A C    1 
ATOM   1277 O O    . ARG A 1 185 ? 6.152   -40.968 -35.869 1.00 27.43  ? 172 ARG A O    1 
ATOM   1278 C CB   . ARG A 1 185 ? 6.266   -38.255 -37.722 1.00 30.45  ? 172 ARG A CB   1 
ATOM   1279 C CG   . ARG A 1 185 ? 5.456   -36.997 -37.974 1.00 29.53  ? 172 ARG A CG   1 
ATOM   1280 C CD   . ARG A 1 185 ? 5.737   -36.197 -39.198 1.00 29.25  ? 172 ARG A CD   1 
ATOM   1281 N NE   . ARG A 1 185 ? 5.292   -36.897 -40.392 1.00 32.61  ? 172 ARG A NE   1 
ATOM   1282 C CZ   . ARG A 1 185 ? 4.174   -36.606 -41.054 1.00 39.26  ? 172 ARG A CZ   1 
ATOM   1283 N NH1  . ARG A 1 185 ? 3.906   -37.272 -42.154 1.00 34.83  ? 172 ARG A NH1  1 
ATOM   1284 N NH2  . ARG A 1 185 ? 3.317   -35.672 -40.635 1.00 39.67  ? 172 ARG A NH2  1 
ATOM   1285 N N    . THR A 1 186 ? 8.159   -39.927 -35.770 1.00 29.32  ? 173 THR A N    1 
ATOM   1286 C CA   . THR A 1 186 ? 8.898   -41.187 -35.589 1.00 35.03  ? 173 THR A CA   1 
ATOM   1287 C C    . THR A 1 186 ? 8.649   -41.755 -34.191 1.00 38.20  ? 173 THR A C    1 
ATOM   1288 O O    . THR A 1 186 ? 8.487   -42.975 -34.030 1.00 31.61  ? 173 THR A O    1 
ATOM   1289 C CB   . THR A 1 186 ? 10.400  -41.056 -35.889 1.00 31.40  ? 173 THR A CB   1 
ATOM   1290 O OG1  . THR A 1 186 ? 11.042  -40.213 -34.931 1.00 37.84  ? 173 THR A OG1  1 
ATOM   1291 C CG2  . THR A 1 186 ? 10.671  -40.521 -37.286 1.00 27.60  ? 173 THR A CG2  1 
ATOM   1292 N N    . LEU A 1 187 ? 8.595   -40.855 -33.183 1.00 34.73  ? 174 LEU A N    1 
ATOM   1293 C CA   . LEU A 1 187 ? 8.298   -41.331 -31.843 1.00 34.80  ? 174 LEU A CA   1 
ATOM   1294 C C    . LEU A 1 187 ? 6.885   -41.896 -31.761 1.00 35.57  ? 174 LEU A C    1 
ATOM   1295 O O    . LEU A 1 187 ? 6.649   -42.872 -31.041 1.00 32.08  ? 174 LEU A O    1 
ATOM   1296 C CB   . LEU A 1 187 ? 8.597   -40.313 -30.752 1.00 32.85  ? 174 LEU A CB   1 
ATOM   1297 C CG   . LEU A 1 187 ? 10.082  -40.003 -30.572 1.00 33.67  ? 174 LEU A CG   1 
ATOM   1298 C CD1  . LEU A 1 187 ? 10.341  -39.268 -29.263 1.00 36.64  ? 174 LEU A CD1  1 
ATOM   1299 C CD2  . LEU A 1 187 ? 10.894  -41.272 -30.617 1.00 36.37  ? 174 LEU A CD2  1 
ATOM   1300 N N    . ALA A 1 188 ? 5.948   -41.276 -32.494 1.00 31.79  ? 175 ALA A N    1 
ATOM   1301 C CA   . ALA A 1 188 ? 4.582   -41.770 -32.510 1.00 32.49  ? 175 ALA A CA   1 
ATOM   1302 C C    . ALA A 1 188 ? 4.572   -43.240 -32.973 1.00 33.39  ? 175 ALA A C    1 
ATOM   1303 O O    . ALA A 1 188 ? 3.827   -44.071 -32.456 1.00 38.39  ? 175 ALA A O    1 
ATOM   1304 C CB   . ALA A 1 188 ? 3.724   -40.910 -33.399 1.00 27.51  ? 175 ALA A CB   1 
ATOM   1305 N N    . ARG A 1 189 ? 5.387   -43.550 -33.966 1.00 32.11  ? 176 ARG A N    1 
ATOM   1306 C CA   . ARG A 1 189 ? 5.416   -44.903 -34.488 1.00 35.66  ? 176 ARG A CA   1 
ATOM   1307 C C    . ARG A 1 189 ? 6.170   -45.788 -33.502 1.00 35.99  ? 176 ARG A C    1 
ATOM   1308 O O    . ARG A 1 189 ? 5.679   -46.852 -33.135 1.00 38.77  ? 176 ARG A O    1 
ATOM   1309 C CB   . ARG A 1 189 ? 6.113   -44.944 -35.862 1.00 36.92  ? 176 ARG A CB   1 
ATOM   1310 C CG   . ARG A 1 189 ? 6.379   -46.341 -36.425 1.00 36.90  ? 176 ARG A CG   1 
ATOM   1311 C CD   . ARG A 1 189 ? 5.140   -47.131 -36.799 1.00 42.79  ? 176 ARG A CD   1 
ATOM   1312 N NE   . ARG A 1 189 ? 4.376   -46.552 -37.916 1.00 45.01  ? 176 ARG A NE   1 
ATOM   1313 C CZ   . ARG A 1 189 ? 3.187   -46.987 -38.340 1.00 44.58  ? 176 ARG A CZ   1 
ATOM   1314 N NH1  . ARG A 1 189 ? 2.679   -48.099 -37.849 1.00 41.87  ? 176 ARG A NH1  1 
ATOM   1315 N NH2  . ARG A 1 189 ? 2.496   -46.315 -39.253 1.00 43.74  ? 176 ARG A NH2  1 
ATOM   1316 N N    . GLU A 1 190 ? 7.349   -45.323 -33.080 1.00 36.03  ? 177 GLU A N    1 
ATOM   1317 C CA   . GLU A 1 190 ? 8.199   -46.144 -32.243 1.00 43.76  ? 177 GLU A CA   1 
ATOM   1318 C C    . GLU A 1 190 ? 7.488   -46.515 -30.941 1.00 43.11  ? 177 GLU A C    1 
ATOM   1319 O O    . GLU A 1 190 ? 7.692   -47.624 -30.449 1.00 45.04  ? 177 GLU A O    1 
ATOM   1320 C CB   . GLU A 1 190 ? 9.604   -45.553 -32.135 1.00 41.63  ? 177 GLU A CB   1 
ATOM   1321 C CG   . GLU A 1 190 ? 10.658  -46.549 -31.669 1.00 43.06  ? 177 GLU A CG   1 
ATOM   1322 C CD   . GLU A 1 190 ? 12.078  -46.100 -31.947 1.00 48.89  ? 177 GLU A CD   1 
ATOM   1323 O OE1  . GLU A 1 190 ? 12.273  -45.044 -32.628 1.00 46.22  ? 177 GLU A OE1  1 
ATOM   1324 O OE2  . GLU A 1 190 ? 12.992  -46.827 -31.470 1.00 49.95  ? 177 GLU A OE2  1 
ATOM   1325 N N    . LEU A 1 191 ? 6.618   -45.643 -30.412 1.00 38.21  ? 178 LEU A N    1 
ATOM   1326 C CA   . LEU A 1 191 ? 6.080   -45.871 -29.076 1.00 38.51  ? 178 LEU A CA   1 
ATOM   1327 C C    . LEU A 1 191 ? 4.614   -46.280 -29.104 1.00 39.58  ? 178 LEU A C    1 
ATOM   1328 O O    . LEU A 1 191 ? 4.097   -46.752 -28.089 1.00 35.29  ? 178 LEU A O    1 
ATOM   1329 C CB   . LEU A 1 191 ? 6.305   -44.689 -28.129 1.00 41.97  ? 178 LEU A CB   1 
ATOM   1330 C CG   . LEU A 1 191 ? 7.771   -44.335 -27.860 1.00 43.37  ? 178 LEU A CG   1 
ATOM   1331 C CD1  . LEU A 1 191 ? 7.949   -43.018 -27.112 1.00 46.88  ? 178 LEU A CD1  1 
ATOM   1332 C CD2  . LEU A 1 191 ? 8.422   -45.462 -27.082 1.00 40.77  ? 178 LEU A CD2  1 
ATOM   1333 N N    . GLY A 1 192 ? 3.947   -46.083 -30.248 1.00 31.56  ? 179 GLY A N    1 
ATOM   1334 C CA   . GLY A 1 192 ? 2.520   -46.340 -30.333 1.00 33.65  ? 179 GLY A CA   1 
ATOM   1335 C C    . GLY A 1 192 ? 2.170   -47.783 -29.953 1.00 40.06  ? 179 GLY A C    1 
ATOM   1336 O O    . GLY A 1 192 ? 1.126   -48.014 -29.359 1.00 31.24  ? 179 GLY A O    1 
ATOM   1337 N N    . GLY A 1 193 ? 3.058   -48.739 -30.260 1.00 44.58  ? 180 GLY A N    1 
ATOM   1338 C CA   . GLY A 1 193 ? 2.813   -50.135 -29.933 1.00 46.64  ? 180 GLY A CA   1 
ATOM   1339 C C    . GLY A 1 193 ? 2.692   -50.349 -28.422 1.00 47.10  ? 180 GLY A C    1 
ATOM   1340 O O    . GLY A 1 193 ? 2.087   -51.329 -27.993 1.00 44.90  ? 180 GLY A O    1 
ATOM   1341 N N    . GLN A 1 194 ? 3.196   -49.381 -27.635 1.00 40.77  ? 181 GLN A N    1 
ATOM   1342 C CA   . GLN A 1 194 ? 3.148   -49.420 -26.177 1.00 43.48  ? 181 GLN A CA   1 
ATOM   1343 C C    . GLN A 1 194 ? 1.959   -48.637 -25.601 1.00 40.55  ? 181 GLN A C    1 
ATOM   1344 O O    . GLN A 1 194 ? 1.823   -48.515 -24.383 1.00 46.09  ? 181 GLN A O    1 
ATOM   1345 C CB   . GLN A 1 194 ? 4.435   -48.824 -25.611 1.00 46.87  ? 181 GLN A CB   1 
ATOM   1346 C CG   . GLN A 1 194 ? 5.693   -49.675 -25.761 1.00 53.11  ? 181 GLN A CG   1 
ATOM   1347 C CD   . GLN A 1 194 ? 6.960   -48.841 -25.688 1.00 58.26  ? 181 GLN A CD   1 
ATOM   1348 O OE1  . GLN A 1 194 ? 7.156   -48.008 -24.791 1.00 58.46  ? 181 GLN A OE1  1 
ATOM   1349 N NE2  . GLN A 1 194 ? 7.837   -49.037 -26.660 1.00 69.07  ? 181 GLN A NE2  1 
ATOM   1350 N N    . GLY A 1 195 ? 1.092   -48.088 -26.454 1.00 36.60  ? 182 GLY A N    1 
ATOM   1351 C CA   . GLY A 1 195 ? -0.035  -47.293 -25.988 1.00 36.70  ? 182 GLY A CA   1 
ATOM   1352 C C    . GLY A 1 195 ? 0.261   -45.784 -25.877 1.00 37.73  ? 182 GLY A C    1 
ATOM   1353 O O    . GLY A 1 195 ? -0.589  -45.024 -25.411 1.00 35.15  ? 182 GLY A O    1 
ATOM   1354 N N    . ILE A 1 196 ? 1.460   -45.347 -26.271 1.00 31.59  ? 183 ILE A N    1 
ATOM   1355 C CA   . ILE A 1 196 ? 1.802   -43.938 -26.118 1.00 36.87  ? 183 ILE A CA   1 
ATOM   1356 C C    . ILE A 1 196 ? 1.490   -43.197 -27.419 1.00 35.95  ? 183 ILE A C    1 
ATOM   1357 O O    . ILE A 1 196 ? 1.967   -43.590 -28.484 1.00 30.26  ? 183 ILE A O    1 
ATOM   1358 C CB   . ILE A 1 196 ? 3.273   -43.749 -25.694 1.00 34.92  ? 183 ILE A CB   1 
ATOM   1359 C CG1  . ILE A 1 196 ? 3.609   -44.553 -24.422 1.00 33.90  ? 183 ILE A CG1  1 
ATOM   1360 C CG2  . ILE A 1 196 ? 3.592   -42.264 -25.482 1.00 37.10  ? 183 ILE A CG2  1 
ATOM   1361 C CD1  . ILE A 1 196 ? 5.084   -44.876 -24.268 1.00 31.32  ? 183 ILE A CD1  1 
ATOM   1362 N N    . ARG A 1 197 ? 0.694   -42.125 -27.299 1.00 35.20  ? 184 ARG A N    1 
ATOM   1363 C CA   . ARG A 1 197 ? 0.417   -41.231 -28.411 1.00 32.41  ? 184 ARG A CA   1 
ATOM   1364 C C    . ARG A 1 197 ? 1.225   -39.941 -28.272 1.00 30.56  ? 184 ARG A C    1 
ATOM   1365 O O    . ARG A 1 197 ? 1.510   -39.494 -27.168 1.00 28.74  ? 184 ARG A O    1 
ATOM   1366 C CB   . ARG A 1 197 ? -1.091  -40.974 -28.591 1.00 32.56  ? 184 ARG A CB   1 
ATOM   1367 C CG   . ARG A 1 197 ? -1.882  -40.391 -27.441 1.00 36.29  ? 184 ARG A CG   1 
ATOM   1368 C CD   . ARG A 1 197 ? -3.383  -40.548 -27.587 1.00 41.47  ? 184 ARG A CD   1 
ATOM   1369 N NE   . ARG A 1 197 ? -3.813  -39.245 -27.062 1.00 39.38  ? 184 ARG A NE   1 
ATOM   1370 C CZ   . ARG A 1 197 ? -4.265  -39.096 -25.827 1.00 44.43  ? 184 ARG A CZ   1 
ATOM   1371 N NH1  . ARG A 1 197 ? -4.398  -40.175 -25.068 1.00 38.45  ? 184 ARG A NH1  1 
ATOM   1372 N NH2  . ARG A 1 197 ? -4.558  -37.889 -25.341 1.00 41.16  ? 184 ARG A NH2  1 
ATOM   1373 N N    . ILE A 1 198 ? 1.605   -39.360 -29.415 1.00 31.91  ? 185 ILE A N    1 
ATOM   1374 C CA   . ILE A 1 198 ? 2.537   -38.254 -29.413 1.00 27.96  ? 185 ILE A CA   1 
ATOM   1375 C C    . ILE A 1 198 ? 2.089   -37.305 -30.508 1.00 27.92  ? 185 ILE A C    1 
ATOM   1376 O O    . ILE A 1 198 ? 1.979   -37.709 -31.661 1.00 29.79  ? 185 ILE A O    1 
ATOM   1377 C CB   . ILE A 1 198 ? 3.995   -38.720 -29.644 1.00 32.36  ? 185 ILE A CB   1 
ATOM   1378 C CG1  . ILE A 1 198 ? 4.436   -39.759 -28.581 1.00 33.95  ? 185 ILE A CG1  1 
ATOM   1379 C CG2  . ILE A 1 198 ? 4.933   -37.505 -29.625 1.00 31.80  ? 185 ILE A CG2  1 
ATOM   1380 C CD1  . ILE A 1 198 ? 5.765   -40.450 -28.804 1.00 32.22  ? 185 ILE A CD1  1 
ATOM   1381 N N    . ASN A 1 199 ? 1.884   -36.035 -30.151 1.00 23.12  ? 186 ASN A N    1 
ATOM   1382 C CA   . ASN A 1 199 ? 1.464   -35.075 -31.146 1.00 23.91  ? 186 ASN A CA   1 
ATOM   1383 C C    . ASN A 1 199 ? 2.220   -33.773 -30.883 1.00 24.47  ? 186 ASN A C    1 
ATOM   1384 O O    . ASN A 1 199 ? 2.858   -33.649 -29.856 1.00 26.14  ? 186 ASN A O    1 
ATOM   1385 C CB   . ASN A 1 199 ? -0.035  -34.808 -31.099 1.00 24.56  ? 186 ASN A CB   1 
ATOM   1386 C CG   . ASN A 1 199 ? -0.863  -36.020 -31.425 1.00 27.30  ? 186 ASN A CG   1 
ATOM   1387 O OD1  . ASN A 1 199 ? -0.931  -36.451 -32.581 1.00 30.77  ? 186 ASN A OD1  1 
ATOM   1388 N ND2  . ASN A 1 199 ? -1.534  -36.553 -30.425 1.00 26.08  ? 186 ASN A ND2  1 
ATOM   1389 N N    . SER A 1 200 ? 2.104   -32.820 -31.810 1.00 21.27  ? 187 SER A N    1 
ATOM   1390 C CA   . SER A 1 200 ? 2.727   -31.535 -31.604 1.00 22.56  ? 187 SER A CA   1 
ATOM   1391 C C    . SER A 1 200 ? 1.633   -30.460 -31.540 1.00 21.02  ? 187 SER A C    1 
ATOM   1392 O O    . SER A 1 200 ? 0.707   -30.431 -32.354 1.00 23.78  ? 187 SER A O    1 
ATOM   1393 C CB   . SER A 1 200 ? 3.723   -31.289 -32.701 1.00 31.38  ? 187 SER A CB   1 
ATOM   1394 O OG   . SER A 1 200 ? 4.422   -30.072 -32.481 1.00 44.82  ? 187 SER A OG   1 
ATOM   1395 N N    . LEU A 1 201 ? 1.708   -29.633 -30.509 1.00 20.98  ? 188 LEU A N    1 
ATOM   1396 C CA   . LEU A 1 201 ? 0.856   -28.453 -30.397 1.00 21.43  ? 188 LEU A CA   1 
ATOM   1397 C C    . LEU A 1 201 ? 1.674   -27.309 -30.998 1.00 22.48  ? 188 LEU A C    1 
ATOM   1398 O O    . LEU A 1 201 ? 2.807   -27.085 -30.597 1.00 24.68  ? 188 LEU A O    1 
ATOM   1399 C CB   . LEU A 1 201 ? 0.545   -28.298 -28.912 1.00 19.62  ? 188 LEU A CB   1 
ATOM   1400 C CG   . LEU A 1 201 ? -0.411  -27.175 -28.468 1.00 25.94  ? 188 LEU A CG   1 
ATOM   1401 C CD1  . LEU A 1 201 ? -0.668  -27.333 -26.963 1.00 24.01  ? 188 LEU A CD1  1 
ATOM   1402 C CD2  . LEU A 1 201 ? 0.064   -25.731 -28.786 1.00 21.07  ? 188 LEU A CD2  1 
ATOM   1403 N N    . VAL A 1 202 ? 1.117   -26.649 -32.012 1.00 21.49  ? 189 VAL A N    1 
ATOM   1404 C CA   . VAL A 1 202 ? 1.899   -25.720 -32.817 1.00 21.32  ? 189 VAL A CA   1 
ATOM   1405 C C    . VAL A 1 202 ? 1.255   -24.325 -32.731 1.00 21.93  ? 189 VAL A C    1 
ATOM   1406 O O    . VAL A 1 202 ? 0.269   -24.017 -33.396 1.00 23.79  ? 189 VAL A O    1 
ATOM   1407 C CB   . VAL A 1 202 ? 1.931   -26.210 -34.274 1.00 22.50  ? 189 VAL A CB   1 
ATOM   1408 C CG1  . VAL A 1 202 ? 2.896   -25.341 -35.089 1.00 22.48  ? 189 VAL A CG1  1 
ATOM   1409 C CG2  . VAL A 1 202 ? 2.332   -27.693 -34.404 1.00 21.08  ? 189 VAL A CG2  1 
ATOM   1410 N N    . PRO A 1 203 ? 1.738   -23.444 -31.857 1.00 23.59  ? 190 PRO A N    1 
ATOM   1411 C CA   . PRO A 1 203 ? 1.084   -22.151 -31.736 1.00 23.38  ? 190 PRO A CA   1 
ATOM   1412 C C    . PRO A 1 203 ? 1.549   -21.173 -32.805 1.00 23.22  ? 190 PRO A C    1 
ATOM   1413 O O    . PRO A 1 203 ? 2.638   -21.310 -33.326 1.00 24.72  ? 190 PRO A O    1 
ATOM   1414 C CB   . PRO A 1 203 ? 1.482   -21.689 -30.341 1.00 22.34  ? 190 PRO A CB   1 
ATOM   1415 C CG   . PRO A 1 203 ? 2.386   -22.719 -29.747 1.00 24.67  ? 190 PRO A CG   1 
ATOM   1416 C CD   . PRO A 1 203 ? 2.764   -23.712 -30.832 1.00 21.09  ? 190 PRO A CD   1 
ATOM   1417 N N    . GLY A 1 204 ? 0.725   -20.154 -33.048 1.00 26.07  ? 191 GLY A N    1 
ATOM   1418 C CA   . GLY A 1 204 ? 1.077   -19.019 -33.853 1.00 25.37  ? 191 GLY A CA   1 
ATOM   1419 C C    . GLY A 1 204 ? 1.743   -18.029 -32.920 1.00 28.60  ? 191 GLY A C    1 
ATOM   1420 O O    . GLY A 1 204 ? 2.509   -18.431 -32.042 1.00 24.51  ? 191 GLY A O    1 
ATOM   1421 N N    . ALA A 1 205 ? 1.378   -16.760 -33.084 1.00 28.61  ? 192 ALA A N    1 
ATOM   1422 C CA   . ALA A 1 205 ? 2.012   -15.689 -32.326 1.00 30.35  ? 192 ALA A CA   1 
ATOM   1423 C C    . ALA A 1 205 ? 1.187   -15.421 -31.071 1.00 32.07  ? 192 ALA A C    1 
ATOM   1424 O O    . ALA A 1 205 ? 0.069   -14.883 -31.107 1.00 31.19  ? 192 ALA A O    1 
ATOM   1425 C CB   . ALA A 1 205 ? 2.238   -14.451 -33.179 1.00 32.50  ? 192 ALA A CB   1 
ATOM   1426 N N    . ILE A 1 206 ? 1.750   -15.888 -29.959 1.00 29.25  ? 193 ILE A N    1 
ATOM   1427 C CA   . ILE A 1 206 ? 1.054   -15.916 -28.691 1.00 31.14  ? 193 ILE A CA   1 
ATOM   1428 C C    . ILE A 1 206 ? 1.467   -14.686 -27.893 1.00 31.32  ? 193 ILE A C    1 
ATOM   1429 O O    . ILE A 1 206 ? 2.657   -14.417 -27.737 1.00 33.03  ? 193 ILE A O    1 
ATOM   1430 C CB   . ILE A 1 206 ? 1.375   -17.230 -27.960 1.00 27.73  ? 193 ILE A CB   1 
ATOM   1431 C CG1  . ILE A 1 206 ? 1.114   -18.436 -28.891 1.00 28.69  ? 193 ILE A CG1  1 
ATOM   1432 C CG2  . ILE A 1 206 ? 0.510   -17.343 -26.712 1.00 30.02  ? 193 ILE A CG2  1 
ATOM   1433 C CD1  . ILE A 1 206 ? -0.324  -18.534 -29.407 1.00 23.31  ? 193 ILE A CD1  1 
ATOM   1434 N N    . ARG A 1 207 ? 0.479   -13.918 -27.433 1.00 29.82  ? 194 ARG A N    1 
ATOM   1435 C CA   . ARG A 1 207 ? 0.758   -12.801 -26.543 1.00 35.35  ? 194 ARG A CA   1 
ATOM   1436 C C    . ARG A 1 207 ? 1.104   -13.402 -25.179 1.00 33.30  ? 194 ARG A C    1 
ATOM   1437 O O    . ARG A 1 207 ? 0.339   -14.192 -24.648 1.00 37.25  ? 194 ARG A O    1 
ATOM   1438 C CB   . ARG A 1 207 ? -0.429  -11.819 -26.579 1.00 35.43  ? 194 ARG A CB   1 
ATOM   1439 C CG   . ARG A 1 207 ? -0.263  -10.457 -25.912 1.00 44.12  ? 194 ARG A CG   1 
ATOM   1440 C CD   . ARG A 1 207 ? -1.430  -9.471  -26.085 1.00 41.83  ? 194 ARG A CD   1 
ATOM   1441 N N    . THR A 1 208 ? 2.297   -13.104 -24.665 1.00 31.85  ? 195 THR A N    1 
ATOM   1442 C CA   . THR A 1 208 ? 2.735   -13.454 -23.322 1.00 39.49  ? 195 THR A CA   1 
ATOM   1443 C C    . THR A 1 208 ? 3.514   -12.244 -22.804 1.00 42.58  ? 195 THR A C    1 
ATOM   1444 O O    . THR A 1 208 ? 3.703   -11.284 -23.548 1.00 44.61  ? 195 THR A O    1 
ATOM   1445 C CB   . THR A 1 208 ? 3.615   -14.710 -23.265 1.00 42.27  ? 195 THR A CB   1 
ATOM   1446 O OG1  . THR A 1 208 ? 4.894   -14.301 -23.735 1.00 46.96  ? 195 THR A OG1  1 
ATOM   1447 C CG2  . THR A 1 208 ? 3.124   -15.878 -24.101 1.00 39.34  ? 195 THR A CG2  1 
ATOM   1448 N N    . GLU A 1 209 ? 3.975   -12.312 -21.546 1.00 49.98  ? 196 GLU A N    1 
ATOM   1449 C CA   . GLU A 1 209 ? 4.732   -11.238 -20.911 1.00 53.54  ? 196 GLU A CA   1 
ATOM   1450 C C    . GLU A 1 209 ? 6.073   -11.033 -21.624 1.00 50.80  ? 196 GLU A C    1 
ATOM   1451 O O    . GLU A 1 209 ? 6.437   -9.896  -21.932 1.00 56.23  ? 196 GLU A O    1 
ATOM   1452 C CB   . GLU A 1 209 ? 4.840   -11.496 -19.409 1.00 53.40  ? 196 GLU A CB   1 
ATOM   1453 N N    . ARG A 1 210 ? 6.775   -12.144 -21.908 1.00 48.24  ? 197 ARG A N    1 
ATOM   1454 C CA   . ARG A 1 210 ? 8.060   -12.151 -22.606 1.00 50.33  ? 197 ARG A CA   1 
ATOM   1455 C C    . ARG A 1 210 ? 7.904   -11.693 -24.062 1.00 54.06  ? 197 ARG A C    1 
ATOM   1456 O O    . ARG A 1 210 ? 8.695   -10.888 -24.562 1.00 47.24  ? 197 ARG A O    1 
ATOM   1457 C CB   . ARG A 1 210 ? 8.698   -13.546 -22.548 1.00 49.11  ? 197 ARG A CB   1 
ATOM   1458 N N    . GLN A 1 211 ? 6.902   -12.241 -24.761 1.00 48.73  ? 198 GLN A N    1 
ATOM   1459 C CA   . GLN A 1 211 ? 6.687   -11.914 -26.164 1.00 54.43  ? 198 GLN A CA   1 
ATOM   1460 C C    . GLN A 1 211 ? 6.385   -10.424 -26.274 1.00 52.35  ? 198 GLN A C    1 
ATOM   1461 O O    . GLN A 1 211 ? 6.924   -9.755  -27.147 1.00 55.06  ? 198 GLN A O    1 
ATOM   1462 C CB   . GLN A 1 211 ? 5.589   -12.733 -26.849 1.00 53.91  ? 198 GLN A CB   1 
ATOM   1463 C CG   . GLN A 1 211 ? 5.920   -14.215 -27.003 1.00 54.11  ? 198 GLN A CG   1 
ATOM   1464 C CD   . GLN A 1 211 ? 7.159   -14.462 -27.838 1.00 55.26  ? 198 GLN A CD   1 
ATOM   1465 O OE1  . GLN A 1 211 ? 7.245   -14.094 -29.018 1.00 56.75  ? 198 GLN A OE1  1 
ATOM   1466 N NE2  . GLN A 1 211 ? 8.138   -15.102 -27.222 1.00 52.97  ? 198 GLN A NE2  1 
ATOM   1467 N N    . ASP A 1 212 ? 5.563   -9.913  -25.353 1.00 48.94  ? 199 ASP A N    1 
ATOM   1468 C CA   . ASP A 1 212 ? 5.325   -8.482  -25.256 1.00 59.74  ? 199 ASP A CA   1 
ATOM   1469 C C    . ASP A 1 212 ? 6.652   -7.737  -25.128 1.00 59.54  ? 199 ASP A C    1 
ATOM   1470 O O    . ASP A 1 212 ? 6.997   -6.979  -26.031 1.00 60.00  ? 199 ASP A O    1 
ATOM   1471 C CB   . ASP A 1 212 ? 4.209   -8.147  -24.280 1.00 53.47  ? 199 ASP A CB   1 
ATOM   1472 C CG   . ASP A 1 212 ? 2.815   -8.452  -24.807 1.00 56.90  ? 199 ASP A CG   1 
ATOM   1473 O OD1  . ASP A 1 212 ? 2.708   -9.111  -25.879 1.00 56.76  ? 199 ASP A OD1  1 
ATOM   1474 O OD2  . ASP A 1 212 ? 1.845   -8.020  -24.153 1.00 54.68  ? 199 ASP A OD2  1 
ATOM   1475 N N    . ALA A 1 213 ? 7.405   -7.983  -24.042 1.00 61.00  ? 200 ALA A N    1 
ATOM   1476 C CA   . ALA A 1 213 ? 8.662   -7.277  -23.818 1.00 58.96  ? 200 ALA A CA   1 
ATOM   1477 C C    . ALA A 1 213 ? 9.591   -7.484  -25.017 1.00 61.28  ? 200 ALA A C    1 
ATOM   1478 O O    . ALA A 1 213 ? 9.901   -6.450  -25.648 1.00 65.70  ? 200 ALA A O    1 
ATOM   1479 C CB   . ALA A 1 213 ? 9.329   -7.708  -22.524 1.00 49.16  ? 200 ALA A CB   1 
ATOM   1480 N N    . ALA A 1 220 ? 3.409   3.380   -31.328 1.00 78.03  ? 207 ALA A N    1 
ATOM   1481 C CA   . ALA A 1 220 ? 2.874   2.039   -30.963 1.00 84.45  ? 207 ALA A CA   1 
ATOM   1482 C C    . ALA A 1 220 ? 3.976   1.140   -30.387 1.00 84.70  ? 207 ALA A C    1 
ATOM   1483 O O    . ALA A 1 220 ? 4.126   1.082   -29.163 1.00 75.87  ? 207 ALA A O    1 
ATOM   1484 C CB   . ALA A 1 220 ? 2.134   1.425   -32.141 1.00 61.44  ? 207 ALA A CB   1 
ATOM   1485 N N    . GLY A 1 221 ? 4.737   0.458   -31.270 1.00 84.54  ? 208 GLY A N    1 
ATOM   1486 C CA   . GLY A 1 221 ? 5.854   -0.423  -30.926 1.00 64.87  ? 208 GLY A CA   1 
ATOM   1487 C C    . GLY A 1 221 ? 5.387   -1.870  -30.729 1.00 65.82  ? 208 GLY A C    1 
ATOM   1488 O O    . GLY A 1 221 ? 5.394   -2.679  -31.673 1.00 48.81  ? 208 GLY A O    1 
ATOM   1489 N N    . LEU A 1 222 ? 4.980   -2.164  -29.483 1.00 56.12  ? 209 LEU A N    1 
ATOM   1490 C CA   . LEU A 1 222 ? 4.226   -3.355  -29.152 1.00 48.75  ? 209 LEU A CA   1 
ATOM   1491 C C    . LEU A 1 222 ? 2.909   -3.321  -29.923 1.00 48.90  ? 209 LEU A C    1 
ATOM   1492 O O    . LEU A 1 222 ? 2.587   -4.260  -30.655 1.00 43.05  ? 209 LEU A O    1 
ATOM   1493 C CB   . LEU A 1 222 ? 4.013   -3.475  -27.642 1.00 51.05  ? 209 LEU A CB   1 
ATOM   1494 N N    . GLU A 1 223 ? 2.189   -2.200  -29.806 1.00 43.46  ? 210 GLU A N    1 
ATOM   1495 C CA   . GLU A 1 223 ? 0.871   -2.061  -30.409 1.00 42.58  ? 210 GLU A CA   1 
ATOM   1496 C C    . GLU A 1 223 ? 0.969   -2.316  -31.913 1.00 44.98  ? 210 GLU A C    1 
ATOM   1497 O O    . GLU A 1 223 ? 0.121   -2.999  -32.492 1.00 43.78  ? 210 GLU A O    1 
ATOM   1498 C CB   . GLU A 1 223 ? 0.198   -0.744  -30.005 1.00 41.57  ? 210 GLU A CB   1 
ATOM   1499 C CG   . GLU A 1 223 ? -1.253  -0.638  -30.477 1.00 40.07  ? 210 GLU A CG   1 
ATOM   1500 N N    . ALA A 1 224 ? 2.026   -1.777  -32.532 1.00 42.44  ? 211 ALA A N    1 
ATOM   1501 C CA   . ALA A 1 224 ? 2.128   -1.831  -33.975 1.00 44.73  ? 211 ALA A CA   1 
ATOM   1502 C C    . ALA A 1 224 ? 2.352   -3.276  -34.426 1.00 42.27  ? 211 ALA A C    1 
ATOM   1503 O O    . ALA A 1 224 ? 1.724   -3.729  -35.378 1.00 54.97  ? 211 ALA A O    1 
ATOM   1504 C CB   . ALA A 1 224 ? 3.218   -0.908  -34.459 1.00 40.20  ? 211 ALA A CB   1 
ATOM   1505 N N    . ALA A 1 225 ? 3.243   -3.982  -33.731 1.00 40.63  ? 212 ALA A N    1 
ATOM   1506 C CA   . ALA A 1 225 ? 3.610   -5.360  -34.062 1.00 41.88  ? 212 ALA A CA   1 
ATOM   1507 C C    . ALA A 1 225 ? 2.424   -6.298  -33.812 1.00 40.73  ? 212 ALA A C    1 
ATOM   1508 O O    . ALA A 1 225 ? 2.179   -7.242  -34.572 1.00 39.38  ? 212 ALA A O    1 
ATOM   1509 C CB   . ALA A 1 225 ? 4.828   -5.766  -33.264 1.00 36.89  ? 212 ALA A CB   1 
ATOM   1510 N N    . SER A 1 226 ? 1.647   -5.980  -32.768 1.00 38.71  ? 213 SER A N    1 
ATOM   1511 C CA   . SER A 1 226 ? 0.457   -6.738  -32.446 1.00 35.18  ? 213 SER A CA   1 
ATOM   1512 C C    . SER A 1 226 ? -0.596  -6.576  -33.546 1.00 43.28  ? 213 SER A C    1 
ATOM   1513 O O    . SER A 1 226 ? -1.263  -7.547  -33.926 1.00 38.25  ? 213 SER A O    1 
ATOM   1514 C CB   . SER A 1 226 ? -0.024  -6.405  -31.062 1.00 27.82  ? 213 SER A CB   1 
ATOM   1515 O OG   . SER A 1 226 ? -1.128  -7.226  -30.704 1.00 38.76  ? 213 SER A OG   1 
ATOM   1516 N N    . GLN A 1 227 ? -0.734  -5.349  -34.081 1.00 41.87  ? 214 GLN A N    1 
ATOM   1517 C CA   . GLN A 1 227 ? -1.674  -5.093  -35.166 1.00 37.33  ? 214 GLN A CA   1 
ATOM   1518 C C    . GLN A 1 227 ? -1.285  -5.850  -36.427 1.00 32.11  ? 214 GLN A C    1 
ATOM   1519 O O    . GLN A 1 227 ? -2.172  -6.319  -37.134 1.00 34.52  ? 214 GLN A O    1 
ATOM   1520 C CB   . GLN A 1 227 ? -1.797  -3.630  -35.612 1.00 46.27  ? 214 GLN A CB   1 
ATOM   1521 C CG   . GLN A 1 227 ? -2.963  -2.883  -34.983 1.00 45.72  ? 214 GLN A CG   1 
ATOM   1522 C CD   . GLN A 1 227 ? -4.274  -3.644  -35.015 1.00 56.10  ? 214 GLN A CD   1 
ATOM   1523 O OE1  . GLN A 1 227 ? -4.734  -4.148  -36.053 1.00 56.21  ? 214 GLN A OE1  1 
ATOM   1524 N NE2  . GLN A 1 227 ? -4.901  -3.716  -33.849 1.00 59.23  ? 214 GLN A NE2  1 
ATOM   1525 N N    . ALA A 1 228 ? 0.026   -5.940  -36.700 1.00 32.43  ? 215 ALA A N    1 
ATOM   1526 C CA   . ALA A 1 228 ? 0.508   -6.643  -37.883 1.00 32.99  ? 215 ALA A CA   1 
ATOM   1527 C C    . ALA A 1 228 ? 0.151   -8.127  -37.807 1.00 33.36  ? 215 ALA A C    1 
ATOM   1528 O O    . ALA A 1 228 ? -0.235  -8.707  -38.822 1.00 36.64  ? 215 ALA A O    1 
ATOM   1529 C CB   . ALA A 1 228 ? 1.976   -6.385  -38.130 1.00 29.99  ? 215 ALA A CB   1 
ATOM   1530 N N    . PHE A 1 229 ? 0.172   -8.712  -36.600 1.00 35.59  ? 216 PHE A N    1 
ATOM   1531 C CA   . PHE A 1 229 ? -0.275  -10.099 -36.434 1.00 34.11  ? 216 PHE A CA   1 
ATOM   1532 C C    . PHE A 1 229 ? -1.761  -10.223 -36.756 1.00 33.24  ? 216 PHE A C    1 
ATOM   1533 O O    . PHE A 1 229 ? -2.159  -11.151 -37.458 1.00 34.87  ? 216 PHE A O    1 
ATOM   1534 C CB   . PHE A 1 229 ? -0.015  -10.731 -35.061 1.00 28.93  ? 216 PHE A CB   1 
ATOM   1535 C CG   . PHE A 1 229 ? 1.447   -10.971 -34.726 1.00 32.01  ? 216 PHE A CG   1 
ATOM   1536 C CD1  . PHE A 1 229 ? 2.268   -11.701 -35.582 1.00 28.83  ? 216 PHE A CD1  1 
ATOM   1537 C CD2  . PHE A 1 229 ? 2.013   -10.447 -33.567 1.00 29.94  ? 216 PHE A CD2  1 
ATOM   1538 C CE1  . PHE A 1 229 ? 3.600   -11.917 -35.278 1.00 27.40  ? 216 PHE A CE1  1 
ATOM   1539 C CE2  . PHE A 1 229 ? 3.352   -10.676 -33.258 1.00 32.99  ? 216 PHE A CE2  1 
ATOM   1540 C CZ   . PHE A 1 229 ? 4.150   -11.390 -34.132 1.00 32.69  ? 216 PHE A CZ   1 
ATOM   1541 N N    . ILE A 1 230 ? -2.574  -9.275  -36.269 1.00 31.72  ? 217 ILE A N    1 
ATOM   1542 C CA   . ILE A 1 230 ? -4.006  -9.304  -36.529 1.00 30.44  ? 217 ILE A CA   1 
ATOM   1543 C C    . ILE A 1 230 ? -4.254  -9.145  -38.029 1.00 29.25  ? 217 ILE A C    1 
ATOM   1544 O O    . ILE A 1 230 ? -5.126  -9.797  -38.603 1.00 30.67  ? 217 ILE A O    1 
ATOM   1545 C CB   . ILE A 1 230 ? -4.774  -8.245  -35.705 1.00 36.34  ? 217 ILE A CB   1 
ATOM   1546 C CG1  . ILE A 1 230 ? -4.785  -8.583  -34.199 1.00 37.42  ? 217 ILE A CG1  1 
ATOM   1547 C CG2  . ILE A 1 230 ? -6.196  -8.013  -36.225 1.00 32.44  ? 217 ILE A CG2  1 
ATOM   1548 C CD1  . ILE A 1 230 ? -5.298  -7.445  -33.317 1.00 34.62  ? 217 ILE A CD1  1 
ATOM   1549 N N    . ASP A 1 231 ? -3.475  -8.298  -38.686 1.00 28.43  ? 218 ASP A N    1 
ATOM   1550 C CA   . ASP A 1 231 ? -3.736  -8.035  -40.092 1.00 31.68  ? 218 ASP A CA   1 
ATOM   1551 C C    . ASP A 1 231 ? -3.338  -9.259  -40.909 1.00 31.98  ? 218 ASP A C    1 
ATOM   1552 O O    . ASP A 1 231 ? -3.942  -9.546  -41.941 1.00 30.75  ? 218 ASP A O    1 
ATOM   1553 C CB   . ASP A 1 231 ? -3.043  -6.764  -40.583 1.00 36.76  ? 218 ASP A CB   1 
ATOM   1554 C CG   . ASP A 1 231 ? -3.407  -5.475  -39.841 1.00 55.17  ? 218 ASP A CG   1 
ATOM   1555 O OD1  . ASP A 1 231 ? -4.360  -5.499  -39.022 1.00 60.51  ? 218 ASP A OD1  1 
ATOM   1556 O OD2  . ASP A 1 231 ? -2.698  -4.448  -40.034 1.00 53.67  ? 218 ASP A OD2  1 
ATOM   1557 N N    . GLN A 1 232 ? -2.354  -10.007 -40.414 1.00 31.52  ? 219 GLN A N    1 
ATOM   1558 C CA   . GLN A 1 232 ? -1.828  -11.124 -41.193 1.00 33.74  ? 219 GLN A CA   1 
ATOM   1559 C C    . GLN A 1 232 ? -2.652  -12.383 -40.961 1.00 31.64  ? 219 GLN A C    1 
ATOM   1560 O O    . GLN A 1 232 ? -2.715  -13.231 -41.860 1.00 31.97  ? 219 GLN A O    1 
ATOM   1561 C CB   . GLN A 1 232 ? -0.375  -11.385 -40.836 1.00 32.09  ? 219 GLN A CB   1 
ATOM   1562 C CG   . GLN A 1 232 ? 0.590   -10.455 -41.563 1.00 34.50  ? 219 GLN A CG   1 
ATOM   1563 C CD   . GLN A 1 232 ? 1.995   -10.600 -41.039 1.00 34.07  ? 219 GLN A CD   1 
ATOM   1564 O OE1  . GLN A 1 232 ? 2.541   -11.707 -40.942 1.00 35.43  ? 219 GLN A OE1  1 
ATOM   1565 N NE2  . GLN A 1 232 ? 2.602   -9.467  -40.739 1.00 30.27  ? 219 GLN A NE2  1 
ATOM   1566 N N    . GLN A 1 233 ? -3.232  -12.488 -39.753 1.00 28.29  ? 220 GLN A N    1 
ATOM   1567 C CA   . GLN A 1 233 ? -4.092  -13.586 -39.340 1.00 28.50  ? 220 GLN A CA   1 
ATOM   1568 C C    . GLN A 1 233 ? -5.409  -13.554 -40.113 1.00 32.56  ? 220 GLN A C    1 
ATOM   1569 O O    . GLN A 1 233 ? -5.839  -12.514 -40.618 1.00 31.16  ? 220 GLN A O    1 
ATOM   1570 C CB   . GLN A 1 233 ? -4.349  -13.547 -37.837 1.00 27.16  ? 220 GLN A CB   1 
ATOM   1571 C CG   . GLN A 1 233 ? -3.140  -13.946 -36.991 1.00 28.25  ? 220 GLN A CG   1 
ATOM   1572 C CD   . GLN A 1 233 ? -3.384  -13.768 -35.507 1.00 32.42  ? 220 GLN A CD   1 
ATOM   1573 O OE1  . GLN A 1 233 ? -4.469  -13.333 -35.097 1.00 35.29  ? 220 GLN A OE1  1 
ATOM   1574 N NE2  . GLN A 1 233 ? -2.384  -14.058 -34.686 1.00 30.58  ? 220 GLN A NE2  1 
ATOM   1575 N N    . MET A 1 234 ? -6.044  -14.725 -40.215 1.00 29.59  ? 221 MET A N    1 
ATOM   1576 C CA   . MET A 1 234 ? -7.398  -14.831 -40.743 1.00 29.47  ? 221 MET A CA   1 
ATOM   1577 C C    . MET A 1 234 ? -8.462  -14.412 -39.728 1.00 31.31  ? 221 MET A C    1 
ATOM   1578 O O    . MET A 1 234 ? -9.435  -13.779 -40.131 1.00 32.80  ? 221 MET A O    1 
ATOM   1579 C CB   . MET A 1 234 ? -7.726  -16.234 -41.243 1.00 23.29  ? 221 MET A CB   1 
ATOM   1580 C CG   . MET A 1 234 ? -6.736  -16.710 -42.329 1.00 25.03  ? 221 MET A CG   1 
ATOM   1581 S SD   . MET A 1 234 ? -7.110  -18.469 -42.466 1.00 29.94  ? 221 MET A SD   1 
ATOM   1582 C CE   . MET A 1 234 ? -5.980  -18.922 -43.784 1.00 35.53  ? 221 MET A CE   1 
ATOM   1583 N N    . LEU A 1 235 ? -8.301  -14.761 -38.441 1.00 30.04  ? 222 LEU A N    1 
ATOM   1584 C CA   . LEU A 1 235 ? -9.225  -14.317 -37.398 1.00 30.50  ? 222 LEU A CA   1 
ATOM   1585 C C    . LEU A 1 235 ? -8.637  -13.081 -36.740 1.00 27.31  ? 222 LEU A C    1 
ATOM   1586 O O    . LEU A 1 235 ? -7.485  -13.105 -36.364 1.00 30.06  ? 222 LEU A O    1 
ATOM   1587 C CB   . LEU A 1 235 ? -9.407  -15.423 -36.347 1.00 30.58  ? 222 LEU A CB   1 
ATOM   1588 C CG   . LEU A 1 235 ? -10.004 -16.745 -36.850 1.00 30.83  ? 222 LEU A CG   1 
ATOM   1589 C CD1  . LEU A 1 235 ? -9.767  -17.844 -35.806 1.00 28.87  ? 222 LEU A CD1  1 
ATOM   1590 C CD2  . LEU A 1 235 ? -11.479 -16.520 -37.088 1.00 28.93  ? 222 LEU A CD2  1 
ATOM   1591 N N    . LYS A 1 236 ? -9.428  -12.024 -36.529 1.00 34.36  ? 223 LYS A N    1 
ATOM   1592 C CA   . LYS A 1 236 ? -8.831  -10.724 -36.259 1.00 34.79  ? 223 LYS A CA   1 
ATOM   1593 C C    . LYS A 1 236 ? -8.714  -10.436 -34.762 1.00 38.54  ? 223 LYS A C    1 
ATOM   1594 O O    . LYS A 1 236 ? -9.195  -9.388  -34.294 1.00 37.75  ? 223 LYS A O    1 
ATOM   1595 C CB   . LYS A 1 236 ? -9.629  -9.643  -37.004 1.00 39.90  ? 223 LYS A CB   1 
ATOM   1596 C CG   . LYS A 1 236 ? -9.667  -9.802  -38.502 1.00 37.31  ? 223 LYS A CG   1 
ATOM   1597 C CD   . LYS A 1 236 ? -8.309  -9.786  -39.202 1.00 40.47  ? 223 LYS A CD   1 
ATOM   1598 C CE   . LYS A 1 236 ? -8.342  -10.249 -40.637 1.00 33.46  ? 223 LYS A CE   1 
ATOM   1599 N NZ   . LYS A 1 236 ? -7.012  -10.124 -41.231 1.00 35.66  ? 223 LYS A NZ   1 
ATOM   1600 N N    . PHE A 1 237 ? -8.078  -11.347 -34.008 1.00 30.86  ? 224 PHE A N    1 
ATOM   1601 C CA   . PHE A 1 237 ? -7.881  -11.131 -32.567 1.00 32.09  ? 224 PHE A CA   1 
ATOM   1602 C C    . PHE A 1 237 ? -6.555  -11.758 -32.151 1.00 29.90  ? 224 PHE A C    1 
ATOM   1603 O O    . PHE A 1 237 ? -6.038  -12.585 -32.884 1.00 31.14  ? 224 PHE A O    1 
ATOM   1604 C CB   . PHE A 1 237 ? -9.032  -11.601 -31.670 1.00 29.78  ? 224 PHE A CB   1 
ATOM   1605 C CG   . PHE A 1 237 ? -9.367  -13.079 -31.807 1.00 32.99  ? 224 PHE A CG   1 
ATOM   1606 C CD1  . PHE A 1 237 ? -8.664  -14.052 -31.095 1.00 34.88  ? 224 PHE A CD1  1 
ATOM   1607 C CD2  . PHE A 1 237 ? -10.385 -13.502 -32.669 1.00 33.47  ? 224 PHE A CD2  1 
ATOM   1608 C CE1  . PHE A 1 237 ? -8.966  -15.405 -31.261 1.00 33.43  ? 224 PHE A CE1  1 
ATOM   1609 C CE2  . PHE A 1 237 ? -10.703 -14.856 -32.800 1.00 30.94  ? 224 PHE A CE2  1 
ATOM   1610 C CZ   . PHE A 1 237 ? -9.985  -15.800 -32.114 1.00 34.73  ? 224 PHE A CZ   1 
ATOM   1611 N N    . ARG A 1 238 ? -5.956  -11.310 -31.040 1.00 28.19  ? 225 ARG A N    1 
ATOM   1612 C CA   . ARG A 1 238 ? -4.660  -11.840 -30.624 1.00 32.28  ? 225 ARG A CA   1 
ATOM   1613 C C    . ARG A 1 238 ? -4.875  -13.134 -29.844 1.00 27.85  ? 225 ARG A C    1 
ATOM   1614 O O    . ARG A 1 238 ? -5.776  -13.217 -29.020 1.00 26.78  ? 225 ARG A O    1 
ATOM   1615 C CB   . ARG A 1 238 ? -3.802  -10.832 -29.845 1.00 32.56  ? 225 ARG A CB   1 
ATOM   1616 C CG   . ARG A 1 238 ? -3.052  -9.963  -30.845 1.00 38.52  ? 225 ARG A CG   1 
ATOM   1617 C CD   . ARG A 1 238 ? -1.981  -10.772 -31.605 1.00 30.23  ? 225 ARG A CD   1 
ATOM   1618 N NE   . ARG A 1 238 ? -0.746  -10.302 -30.977 1.00 40.25  ? 225 ARG A NE   1 
ATOM   1619 C CZ   . ARG A 1 238 ? 0.217   -10.924 -30.342 1.00 38.78  ? 225 ARG A CZ   1 
ATOM   1620 N NH1  . ARG A 1 238 ? 0.411   -12.194 -30.472 1.00 36.34  ? 225 ARG A NH1  1 
ATOM   1621 N NH2  . ARG A 1 238 ? 1.048   -10.251 -29.577 1.00 52.65  ? 225 ARG A NH2  1 
ATOM   1622 N N    . LEU A 1 239 ? -4.069  -14.156 -30.140 1.00 29.31  ? 226 LEU A N    1 
ATOM   1623 C CA   . LEU A 1 239 ? -4.110  -15.399 -29.385 1.00 26.73  ? 226 LEU A CA   1 
ATOM   1624 C C    . LEU A 1 239 ? -3.281  -15.178 -28.125 1.00 28.98  ? 226 LEU A C    1 
ATOM   1625 O O    . LEU A 1 239 ? -2.355  -14.352 -28.109 1.00 32.20  ? 226 LEU A O    1 
ATOM   1626 C CB   . LEU A 1 239 ? -3.519  -16.554 -30.204 1.00 23.16  ? 226 LEU A CB   1 
ATOM   1627 C CG   . LEU A 1 239 ? -4.136  -16.833 -31.583 1.00 26.73  ? 226 LEU A CG   1 
ATOM   1628 C CD1  . LEU A 1 239 ? -3.337  -17.901 -32.331 1.00 25.39  ? 226 LEU A CD1  1 
ATOM   1629 C CD2  . LEU A 1 239 ? -5.516  -17.377 -31.391 1.00 25.08  ? 226 LEU A CD2  1 
ATOM   1630 N N    . ASP A 1 240 ? -3.619  -15.923 -27.071 1.00 35.67  ? 227 ASP A N    1 
ATOM   1631 C CA   . ASP A 1 240 ? -2.886  -15.869 -25.813 1.00 34.28  ? 227 ASP A CA   1 
ATOM   1632 C C    . ASP A 1 240 ? -2.625  -17.295 -25.328 1.00 30.95  ? 227 ASP A C    1 
ATOM   1633 O O    . ASP A 1 240 ? -2.919  -18.274 -26.016 1.00 31.47  ? 227 ASP A O    1 
ATOM   1634 C CB   . ASP A 1 240 ? -3.590  -15.009 -24.767 1.00 38.34  ? 227 ASP A CB   1 
ATOM   1635 C CG   . ASP A 1 240 ? -5.022  -15.408 -24.432 1.00 45.91  ? 227 ASP A CG   1 
ATOM   1636 O OD1  . ASP A 1 240 ? -5.286  -16.629 -24.248 1.00 45.65  ? 227 ASP A OD1  1 
ATOM   1637 O OD2  . ASP A 1 240 ? -5.866  -14.492 -24.324 1.00 50.95  ? 227 ASP A OD2  1 
ATOM   1638 N N    . ALA A 1 241 ? -2.068  -17.386 -24.123 1.00 26.92  ? 228 ALA A N    1 
ATOM   1639 C CA   . ALA A 1 241 ? -1.620  -18.625 -23.508 1.00 22.42  ? 228 ALA A CA   1 
ATOM   1640 C C    . ALA A 1 241 ? -2.798  -19.574 -23.321 1.00 28.39  ? 228 ALA A C    1 
ATOM   1641 O O    . ALA A 1 241 ? -2.609  -20.781 -23.363 1.00 26.62  ? 228 ALA A O    1 
ATOM   1642 C CB   . ALA A 1 241 ? -0.924  -18.350 -22.171 1.00 17.68  ? 228 ALA A CB   1 
ATOM   1643 N N    . SER A 1 242 ? -3.997  -19.012 -23.102 1.00 26.28  ? 229 SER A N    1 
ATOM   1644 C CA   . SER A 1 242 ? -5.175  -19.800 -22.799 1.00 25.22  ? 229 SER A CA   1 
ATOM   1645 C C    . SER A 1 242 ? -5.556  -20.591 -24.039 1.00 25.67  ? 229 SER A C    1 
ATOM   1646 O O    . SER A 1 242 ? -6.041  -21.721 -23.943 1.00 27.48  ? 229 SER A O    1 
ATOM   1647 C CB   . SER A 1 242 ? -6.363  -18.932 -22.348 1.00 25.01  ? 229 SER A CB   1 
ATOM   1648 O OG   . SER A 1 242 ? -6.061  -18.279 -21.123 1.00 30.52  ? 229 SER A OG   1 
ATOM   1649 N N    . ASP A 1 243 ? -5.320  -19.984 -25.198 1.00 24.90  ? 230 ASP A N    1 
ATOM   1650 C CA   . ASP A 1 243 ? -5.625  -20.655 -26.447 1.00 26.74  ? 230 ASP A CA   1 
ATOM   1651 C C    . ASP A 1 243 ? -4.809  -21.939 -26.583 1.00 24.69  ? 230 ASP A C    1 
ATOM   1652 O O    . ASP A 1 243 ? -5.322  -22.940 -27.077 1.00 25.74  ? 230 ASP A O    1 
ATOM   1653 C CB   . ASP A 1 243 ? -5.349  -19.745 -27.627 1.00 24.19  ? 230 ASP A CB   1 
ATOM   1654 C CG   . ASP A 1 243 ? -6.352  -18.610 -27.755 1.00 30.78  ? 230 ASP A CG   1 
ATOM   1655 O OD1  . ASP A 1 243 ? -7.484  -18.910 -28.137 1.00 30.10  ? 230 ASP A OD1  1 
ATOM   1656 O OD2  . ASP A 1 243 ? -5.961  -17.446 -27.511 1.00 30.01  ? 230 ASP A OD2  1 
ATOM   1657 N N    . CYS A 1 244 ? -3.543  -21.881 -26.148 1.00 26.65  ? 231 CYS A N    1 
ATOM   1658 C CA   . CYS A 1 244 ? -2.618  -23.011 -26.183 1.00 22.70  ? 231 CYS A CA   1 
ATOM   1659 C C    . CYS A 1 244 ? -3.076  -24.053 -25.160 1.00 22.81  ? 231 CYS A C    1 
ATOM   1660 O O    . CYS A 1 244 ? -3.106  -25.247 -25.468 1.00 24.83  ? 231 CYS A O    1 
ATOM   1661 C CB   . CYS A 1 244 ? -1.181  -22.548 -25.919 1.00 24.85  ? 231 CYS A CB   1 
ATOM   1662 S SG   . CYS A 1 244 ? -0.533  -21.406 -27.191 1.00 28.76  ? 231 CYS A SG   1 
ATOM   1663 N N    . ALA A 1 245 ? -3.472  -23.590 -23.961 1.00 23.00  ? 232 ALA A N    1 
ATOM   1664 C CA   . ALA A 1 245 ? -3.822  -24.498 -22.880 1.00 25.42  ? 232 ALA A CA   1 
ATOM   1665 C C    . ALA A 1 245 ? -5.058  -25.324 -23.214 1.00 25.20  ? 232 ALA A C    1 
ATOM   1666 O O    . ALA A 1 245 ? -5.106  -26.539 -22.937 1.00 30.78  ? 232 ALA A O    1 
ATOM   1667 C CB   . ALA A 1 245 ? -3.952  -23.704 -21.578 1.00 25.32  ? 232 ALA A CB   1 
ATOM   1668 N N    . ARG A 1 246 ? -6.036  -24.659 -23.861 1.00 24.79  ? 233 ARG A N    1 
ATOM   1669 C CA   . ARG A 1 246 ? -7.265  -25.329 -24.258 1.00 26.83  ? 233 ARG A CA   1 
ATOM   1670 C C    . ARG A 1 246 ? -6.928  -26.430 -25.242 1.00 27.39  ? 233 ARG A C    1 
ATOM   1671 O O    . ARG A 1 246 ? -7.473  -27.531 -25.141 1.00 28.53  ? 233 ARG A O    1 
ATOM   1672 C CB   . ARG A 1 246 ? -8.258  -24.351 -24.890 1.00 30.64  ? 233 ARG A CB   1 
ATOM   1673 C CG   . ARG A 1 246 ? -8.832  -23.448 -23.814 1.00 29.02  ? 233 ARG A CG   1 
ATOM   1674 C CD   . ARG A 1 246 ? -9.887  -22.629 -24.509 1.00 33.24  ? 233 ARG A CD   1 
ATOM   1675 N NE   . ARG A 1 246 ? -9.770  -21.297 -23.915 1.00 40.10  ? 233 ARG A NE   1 
ATOM   1676 C CZ   . ARG A 1 246 ? -9.287  -20.271 -24.591 1.00 40.69  ? 233 ARG A CZ   1 
ATOM   1677 N NH1  . ARG A 1 246 ? -9.088  -20.352 -25.901 1.00 41.86  ? 233 ARG A NH1  1 
ATOM   1678 N NH2  . ARG A 1 246 ? -9.060  -19.154 -23.946 1.00 40.26  ? 233 ARG A NH2  1 
ATOM   1679 N N    . LEU A 1 247 ? -6.010  -26.135 -26.180 1.00 23.38  ? 234 LEU A N    1 
ATOM   1680 C CA   . LEU A 1 247 ? -5.593  -27.174 -27.114 1.00 25.16  ? 234 LEU A CA   1 
ATOM   1681 C C    . LEU A 1 247 ? -4.890  -28.319 -26.375 1.00 25.28  ? 234 LEU A C    1 
ATOM   1682 O O    . LEU A 1 247 ? -5.207  -29.494 -26.621 1.00 30.17  ? 234 LEU A O    1 
ATOM   1683 C CB   . LEU A 1 247 ? -4.767  -26.599 -28.266 1.00 26.09  ? 234 LEU A CB   1 
ATOM   1684 C CG   . LEU A 1 247 ? -4.269  -27.601 -29.320 1.00 25.12  ? 234 LEU A CG   1 
ATOM   1685 C CD1  . LEU A 1 247 ? -5.351  -28.578 -29.770 1.00 21.87  ? 234 LEU A CD1  1 
ATOM   1686 C CD2  . LEU A 1 247 ? -3.779  -26.780 -30.495 1.00 23.08  ? 234 LEU A CD2  1 
ATOM   1687 N N    . ALA A 1 248 ? -3.949  -27.977 -25.466 1.00 22.75  ? 235 ALA A N    1 
ATOM   1688 C CA   . ALA A 1 248 ? -3.257  -28.990 -24.670 1.00 25.01  ? 235 ALA A CA   1 
ATOM   1689 C C    . ALA A 1 248 ? -4.180  -29.960 -23.910 1.00 27.27  ? 235 ALA A C    1 
ATOM   1690 O O    . ALA A 1 248 ? -3.896  -31.166 -23.822 1.00 25.44  ? 235 ALA A O    1 
ATOM   1691 C CB   . ALA A 1 248 ? -2.260  -28.337 -23.741 1.00 23.98  ? 235 ALA A CB   1 
ATOM   1692 N N    . LEU A 1 249 ? -5.246  -29.425 -23.305 1.00 24.85  ? 236 LEU A N    1 
ATOM   1693 C CA   . LEU A 1 249 ? -6.164  -30.237 -22.508 1.00 29.17  ? 236 LEU A CA   1 
ATOM   1694 C C    . LEU A 1 249 ? -6.805  -31.287 -23.412 1.00 34.07  ? 236 LEU A C    1 
ATOM   1695 O O    . LEU A 1 249 ? -6.936  -32.464 -23.029 1.00 31.52  ? 236 LEU A O    1 
ATOM   1696 C CB   . LEU A 1 249 ? -7.254  -29.370 -21.867 1.00 26.08  ? 236 LEU A CB   1 
ATOM   1697 C CG   . LEU A 1 249 ? -6.817  -28.396 -20.767 1.00 26.45  ? 236 LEU A CG   1 
ATOM   1698 C CD1  . LEU A 1 249 ? -7.973  -27.539 -20.319 1.00 21.45  ? 236 LEU A CD1  1 
ATOM   1699 C CD2  . LEU A 1 249 ? -6.230  -29.101 -19.540 1.00 27.09  ? 236 LEU A CD2  1 
ATOM   1700 N N    . PHE A 1 250 ? -7.189  -30.848 -24.630 1.00 32.24  ? 237 PHE A N    1 
ATOM   1701 C CA   . PHE A 1 250 ? -7.851  -31.761 -25.557 1.00 32.33  ? 237 PHE A CA   1 
ATOM   1702 C C    . PHE A 1 250 ? -6.884  -32.883 -25.939 1.00 33.64  ? 237 PHE A C    1 
ATOM   1703 O O    . PHE A 1 250 ? -7.257  -34.069 -25.955 1.00 25.83  ? 237 PHE A O    1 
ATOM   1704 C CB   . PHE A 1 250 ? -8.433  -30.988 -26.754 1.00 32.35  ? 237 PHE A CB   1 
ATOM   1705 C CG   . PHE A 1 250 ? -8.899  -31.939 -27.846 1.00 35.03  ? 237 PHE A CG   1 
ATOM   1706 C CD1  . PHE A 1 250 ? -10.144 -32.567 -27.756 1.00 33.01  ? 237 PHE A CD1  1 
ATOM   1707 C CD2  . PHE A 1 250 ? -8.073  -32.263 -28.920 1.00 33.33  ? 237 PHE A CD2  1 
ATOM   1708 C CE1  . PHE A 1 250 ? -10.548 -33.466 -28.729 1.00 33.25  ? 237 PHE A CE1  1 
ATOM   1709 C CE2  . PHE A 1 250 ? -8.485  -33.178 -29.894 1.00 32.76  ? 237 PHE A CE2  1 
ATOM   1710 C CZ   . PHE A 1 250 ? -9.731  -33.758 -29.796 1.00 31.94  ? 237 PHE A CZ   1 
ATOM   1711 N N    . LEU A 1 251 ? -5.629  -32.490 -26.237 1.00 28.25  ? 238 LEU A N    1 
ATOM   1712 C CA   . LEU A 1 251 ? -4.591  -33.433 -26.692 1.00 26.25  ? 238 LEU A CA   1 
ATOM   1713 C C    . LEU A 1 251 ? -4.167  -34.374 -25.566 1.00 28.01  ? 238 LEU A C    1 
ATOM   1714 O O    . LEU A 1 251 ? -3.589  -35.441 -25.820 1.00 26.95  ? 238 LEU A O    1 
ATOM   1715 C CB   . LEU A 1 251 ? -3.370  -32.721 -27.311 1.00 24.65  ? 238 LEU A CB   1 
ATOM   1716 C CG   . LEU A 1 251 ? -3.650  -31.997 -28.641 1.00 27.25  ? 238 LEU A CG   1 
ATOM   1717 C CD1  . LEU A 1 251 ? -2.589  -31.059 -29.178 1.00 32.49  ? 238 LEU A CD1  1 
ATOM   1718 C CD2  . LEU A 1 251 ? -3.998  -33.035 -29.724 1.00 26.10  ? 238 LEU A CD2  1 
ATOM   1719 N N    . ALA A 1 252 ? -4.395  -33.956 -24.303 1.00 27.68  ? 239 ALA A N    1 
ATOM   1720 C CA   . ALA A 1 252 ? -4.102  -34.818 -23.173 1.00 30.10  ? 239 ALA A CA   1 
ATOM   1721 C C    . ALA A 1 252 ? -5.264  -35.773 -22.822 1.00 34.64  ? 239 ALA A C    1 
ATOM   1722 O O    . ALA A 1 252 ? -5.037  -36.865 -22.304 1.00 36.09  ? 239 ALA A O    1 
ATOM   1723 C CB   . ALA A 1 252 ? -3.672  -33.989 -21.993 1.00 30.40  ? 239 ALA A CB   1 
ATOM   1724 N N    . SER A 1 253 ? -6.502  -35.352 -23.057 1.00 30.53  ? 240 SER A N    1 
ATOM   1725 C CA   . SER A 1 253 ? -7.682  -36.072 -22.596 1.00 35.16  ? 240 SER A CA   1 
ATOM   1726 C C    . SER A 1 253 ? -7.952  -37.331 -23.429 1.00 37.38  ? 240 SER A C    1 
ATOM   1727 O O    . SER A 1 253 ? -7.361  -37.512 -24.484 1.00 32.66  ? 240 SER A O    1 
ATOM   1728 C CB   . SER A 1 253 ? -8.870  -35.165 -22.636 1.00 33.95  ? 240 SER A CB   1 
ATOM   1729 O OG   . SER A 1 253 ? -9.357  -35.037 -23.971 1.00 40.15  ? 240 SER A OG   1 
ATOM   1730 N N    . ASP A 1 254 ? -8.921  -38.155 -23.000 1.00 39.42  ? 241 ASP A N    1 
ATOM   1731 C CA   . ASP A 1 254 ? -9.367  -39.351 -23.714 1.00 41.48  ? 241 ASP A CA   1 
ATOM   1732 C C    . ASP A 1 254 ? -10.184 -39.050 -24.984 1.00 32.30  ? 241 ASP A C    1 
ATOM   1733 C CB   . ASP A 1 254 ? -10.180 -40.255 -22.805 1.00 39.75  ? 241 ASP A CB   1 
ATOM   1734 C CG   . ASP A 1 254 ? -9.406  -41.030 -21.745 1.00 47.24  ? 241 ASP A CG   1 
ATOM   1735 O OD1  . ASP A 1 254 ? -8.156  -41.031 -21.775 1.00 50.80  ? 241 ASP A OD1  1 
ATOM   1736 O OD2  . ASP A 1 254 ? -10.070 -41.635 -20.879 1.00 59.52  ? 241 ASP A OD2  1 
ATOM   1737 N N    . ASP A 1 255 ? -10.459 -37.760 -25.182 1.00 37.27  ? 242 ASP A N    1 
ATOM   1738 C CA   . ASP A 1 255 ? -11.148 -37.315 -26.382 1.00 40.40  ? 242 ASP A CA   1 
ATOM   1739 C C    . ASP A 1 255 ? -10.217 -37.238 -27.594 1.00 41.78  ? 242 ASP A C    1 
ATOM   1740 O O    . ASP A 1 255 ? -10.711 -37.060 -28.709 1.00 41.83  ? 242 ASP A O    1 
ATOM   1741 C CB   . ASP A 1 255 ? -11.751 -35.933 -26.233 1.00 38.93  ? 242 ASP A CB   1 
ATOM   1742 C CG   . ASP A 1 255 ? -12.886 -35.824 -25.231 1.00 43.11  ? 242 ASP A CG   1 
ATOM   1743 O OD1  . ASP A 1 255 ? -12.584 -35.765 -24.023 1.00 46.11  ? 242 ASP A OD1  1 
ATOM   1744 O OD2  . ASP A 1 255 ? -14.049 -35.782 -25.673 1.00 39.08  ? 242 ASP A OD2  1 
ATOM   1745 N N    . SER A 1 256 ? -8.896  -37.337 -27.385 1.00 30.73  ? 243 SER A N    1 
ATOM   1746 C CA   . SER A 1 256 ? -7.956  -37.381 -28.500 1.00 29.47  ? 243 SER A CA   1 
ATOM   1747 C C    . SER A 1 256 ? -7.229  -38.718 -28.471 1.00 29.17  ? 243 SER A C    1 
ATOM   1748 O O    . SER A 1 256 ? -6.149  -38.805 -29.023 1.00 27.89  ? 243 SER A O    1 
ATOM   1749 C CB   . SER A 1 256 ? -6.951  -36.218 -28.496 1.00 29.28  ? 243 SER A CB   1 
ATOM   1750 O OG   . SER A 1 256 ? -6.243  -36.195 -27.260 1.00 34.06  ? 243 SER A OG   1 
ATOM   1751 N N    . ARG A 1 257 ? -7.844  -39.753 -27.865 1.00 28.58  ? 244 ARG A N    1 
ATOM   1752 C CA   . ARG A 1 257 ? -7.158  -41.022 -27.659 1.00 29.40  ? 244 ARG A CA   1 
ATOM   1753 C C    . ARG A 1 257 ? -6.584  -41.580 -28.965 1.00 28.84  ? 244 ARG A C    1 
ATOM   1754 O O    . ARG A 1 257 ? -5.551  -42.262 -28.944 1.00 33.22  ? 244 ARG A O    1 
ATOM   1755 C CB   . ARG A 1 257 ? -7.968  -42.066 -26.865 1.00 30.37  ? 244 ARG A CB   1 
ATOM   1756 C CG   . ARG A 1 257 ? -9.280  -42.593 -27.433 1.00 38.91  ? 244 ARG A CG   1 
ATOM   1757 N N    . GLY A 1 258 ? -7.299  -41.366 -30.077 1.00 29.77  ? 245 GLY A N    1 
ATOM   1758 C CA   . GLY A 1 258 ? -6.935  -41.989 -31.339 1.00 30.66  ? 245 GLY A CA   1 
ATOM   1759 C C    . GLY A 1 258 ? -5.989  -41.117 -32.176 1.00 33.87  ? 245 GLY A C    1 
ATOM   1760 O O    . GLY A 1 258 ? -5.602  -41.535 -33.264 1.00 33.63  ? 245 GLY A O    1 
ATOM   1761 N N    . CYS A 1 259 ? -5.605  -39.928 -31.671 1.00 29.49  ? 246 CYS A N    1 
ATOM   1762 C CA   . CYS A 1 259 ? -4.781  -39.002 -32.460 1.00 27.20  ? 246 CYS A CA   1 
ATOM   1763 C C    . CYS A 1 259 ? -3.303  -39.150 -32.113 1.00 26.26  ? 246 CYS A C    1 
ATOM   1764 O O    . CYS A 1 259 ? -2.911  -39.082 -30.935 1.00 25.58  ? 246 CYS A O    1 
ATOM   1765 C CB   . CYS A 1 259 ? -5.167  -37.562 -32.132 1.00 27.95  ? 246 CYS A CB   1 
ATOM   1766 S SG   . CYS A 1 259 ? -6.852  -37.130 -32.604 1.00 33.82  ? 246 CYS A SG   1 
ATOM   1767 N N    . THR A 1 260 ? -2.464  -39.396 -33.125 1.00 27.14  ? 247 THR A N    1 
ATOM   1768 C CA   . THR A 1 260 ? -1.042  -39.536 -32.872 1.00 27.47  ? 247 THR A CA   1 
ATOM   1769 C C    . THR A 1 260 ? -0.283  -39.200 -34.151 1.00 26.85  ? 247 THR A C    1 
ATOM   1770 O O    . THR A 1 260 ? -0.831  -39.320 -35.243 1.00 25.62  ? 247 THR A O    1 
ATOM   1771 C CB   . THR A 1 260 ? -0.717  -40.959 -32.406 1.00 29.01  ? 247 THR A CB   1 
ATOM   1772 O OG1  . THR A 1 260 ? 0.561   -40.928 -31.791 1.00 24.36  ? 247 THR A OG1  1 
ATOM   1773 C CG2  . THR A 1 260 ? -0.781  -41.965 -33.540 1.00 30.57  ? 247 THR A CG2  1 
ATOM   1774 N N    . GLY A 1 261 ? 0.982   -38.784 -33.972 1.00 26.68  ? 248 GLY A N    1 
ATOM   1775 C CA   . GLY A 1 261 ? 1.862   -38.460 -35.082 1.00 28.14  ? 248 GLY A CA   1 
ATOM   1776 C C    . GLY A 1 261 ? 1.565   -37.109 -35.728 1.00 30.68  ? 248 GLY A C    1 
ATOM   1777 O O    . GLY A 1 261 ? 2.126   -36.836 -36.790 1.00 30.97  ? 248 GLY A O    1 
ATOM   1778 N N    . GLN A 1 262 ? 0.691   -36.283 -35.118 1.00 25.25  ? 249 GLN A N    1 
ATOM   1779 C CA   . GLN A 1 262 ? 0.078   -35.207 -35.889 1.00 27.55  ? 249 GLN A CA   1 
ATOM   1780 C C    . GLN A 1 262 ? 0.382   -33.814 -35.321 1.00 27.99  ? 249 GLN A C    1 
ATOM   1781 O O    . GLN A 1 262 ? 0.620   -33.636 -34.136 1.00 27.53  ? 249 GLN A O    1 
ATOM   1782 C CB   . GLN A 1 262 ? -1.433  -35.391 -35.964 1.00 26.46  ? 249 GLN A CB   1 
ATOM   1783 C CG   . GLN A 1 262 ? -1.865  -36.457 -36.973 1.00 28.91  ? 249 GLN A CG   1 
ATOM   1784 C CD   . GLN A 1 262 ? -1.524  -36.036 -38.380 1.00 29.83  ? 249 GLN A CD   1 
ATOM   1785 O OE1  . GLN A 1 262 ? -1.611  -34.853 -38.731 1.00 35.72  ? 249 GLN A OE1  1 
ATOM   1786 N NE2  . GLN A 1 262 ? -0.996  -36.956 -39.167 1.00 28.72  ? 249 GLN A NE2  1 
ATOM   1787 N N    . ASN A 1 263 ? 0.352   -32.807 -36.192 1.00 23.11  ? 250 ASN A N    1 
ATOM   1788 C CA   . ASN A 1 263 ? 0.352   -31.427 -35.722 1.00 23.08  ? 250 ASN A CA   1 
ATOM   1789 C C    . ASN A 1 263 ? -1.072  -30.927 -35.491 1.00 21.49  ? 250 ASN A C    1 
ATOM   1790 O O    . ASN A 1 263 ? -1.954  -31.216 -36.283 1.00 25.17  ? 250 ASN A O    1 
ATOM   1791 C CB   . ASN A 1 263 ? 0.983   -30.501 -36.764 1.00 22.38  ? 250 ASN A CB   1 
ATOM   1792 C CG   . ASN A 1 263 ? 2.461   -30.751 -36.934 1.00 26.29  ? 250 ASN A CG   1 
ATOM   1793 O OD1  . ASN A 1 263 ? 3.176   -30.983 -35.953 1.00 31.38  ? 250 ASN A OD1  1 
ATOM   1794 N ND2  . ASN A 1 263 ? 2.918   -30.750 -38.171 1.00 28.16  ? 250 ASN A ND2  1 
ATOM   1795 N N    . PHE A 1 264 ? -1.264  -30.076 -34.475 1.00 22.09  ? 251 PHE A N    1 
ATOM   1796 C CA   . PHE A 1 264 ? -2.510  -29.346 -34.301 1.00 21.30  ? 251 PHE A CA   1 
ATOM   1797 C C    . PHE A 1 264 ? -2.108  -27.868 -34.157 1.00 21.86  ? 251 PHE A C    1 
ATOM   1798 O O    . PHE A 1 264 ? -1.397  -27.519 -33.222 1.00 24.46  ? 251 PHE A O    1 
ATOM   1799 C CB   . PHE A 1 264 ? -3.108  -29.874 -32.993 1.00 26.89  ? 251 PHE A CB   1 
ATOM   1800 C CG   . PHE A 1 264 ? -3.575  -31.325 -33.104 1.00 27.61  ? 251 PHE A CG   1 
ATOM   1801 C CD1  . PHE A 1 264 ? -2.699  -32.388 -32.888 1.00 29.28  ? 251 PHE A CD1  1 
ATOM   1802 C CD2  . PHE A 1 264 ? -4.882  -31.617 -33.455 1.00 32.76  ? 251 PHE A CD2  1 
ATOM   1803 C CE1  . PHE A 1 264 ? -3.127  -33.710 -33.022 1.00 32.16  ? 251 PHE A CE1  1 
ATOM   1804 C CE2  . PHE A 1 264 ? -5.318  -32.945 -33.579 1.00 35.03  ? 251 PHE A CE2  1 
ATOM   1805 C CZ   . PHE A 1 264 ? -4.436  -33.987 -33.353 1.00 34.64  ? 251 PHE A CZ   1 
ATOM   1806 N N    . VAL A 1 265 ? -2.537  -27.042 -35.102 1.00 22.30  ? 252 VAL A N    1 
ATOM   1807 C CA   . VAL A 1 265 ? -2.027  -25.687 -35.206 1.00 23.30  ? 252 VAL A CA   1 
ATOM   1808 C C    . VAL A 1 265 ? -3.080  -24.726 -34.654 1.00 22.68  ? 252 VAL A C    1 
ATOM   1809 O O    . VAL A 1 265 ? -4.247  -24.742 -35.097 1.00 25.07  ? 252 VAL A O    1 
ATOM   1810 C CB   . VAL A 1 265 ? -1.746  -25.418 -36.696 1.00 22.85  ? 252 VAL A CB   1 
ATOM   1811 C CG1  . VAL A 1 265 ? -1.228  -23.985 -36.858 1.00 24.67  ? 252 VAL A CG1  1 
ATOM   1812 C CG2  . VAL A 1 265 ? -0.727  -26.430 -37.259 1.00 19.67  ? 252 VAL A CG2  1 
ATOM   1813 N N    . VAL A 1 266 ? -2.663  -23.932 -33.661 1.00 20.94  ? 253 VAL A N    1 
ATOM   1814 C CA   . VAL A 1 266 ? -3.536  -22.921 -33.089 1.00 22.28  ? 253 VAL A CA   1 
ATOM   1815 C C    . VAL A 1 266 ? -2.892  -21.566 -33.397 1.00 22.45  ? 253 VAL A C    1 
ATOM   1816 O O    . VAL A 1 266 ? -2.018  -21.145 -32.649 1.00 22.19  ? 253 VAL A O    1 
ATOM   1817 C CB   . VAL A 1 266 ? -3.838  -23.103 -31.591 1.00 21.71  ? 253 VAL A CB   1 
ATOM   1818 C CG1  . VAL A 1 266 ? -2.595  -23.319 -30.728 1.00 25.59  ? 253 VAL A CG1  1 
ATOM   1819 C CG2  . VAL A 1 266 ? -4.792  -22.019 -31.021 1.00 21.40  ? 253 VAL A CG2  1 
ATOM   1820 N N    . ASP A 1 267 ? -3.286  -20.953 -34.521 1.00 22.30  ? 254 ASP A N    1 
ATOM   1821 C CA   . ASP A 1 267 ? -2.530  -19.820 -35.048 1.00 25.64  ? 254 ASP A CA   1 
ATOM   1822 C C    . ASP A 1 267 ? -3.415  -18.764 -35.702 1.00 27.06  ? 254 ASP A C    1 
ATOM   1823 O O    . ASP A 1 267 ? -2.884  -17.823 -36.290 1.00 26.63  ? 254 ASP A O    1 
ATOM   1824 C CB   . ASP A 1 267 ? -1.463  -20.289 -36.027 1.00 24.53  ? 254 ASP A CB   1 
ATOM   1825 C CG   . ASP A 1 267 ? -1.914  -20.648 -37.431 1.00 28.62  ? 254 ASP A CG   1 
ATOM   1826 O OD1  . ASP A 1 267 ? -3.126  -20.892 -37.618 1.00 28.83  ? 254 ASP A OD1  1 
ATOM   1827 O OD2  . ASP A 1 267 ? -1.041  -20.628 -38.358 1.00 32.34  ? 254 ASP A OD2  1 
ATOM   1828 N N    . ALA A 1 268 ? -4.747  -18.912 -35.614 1.00 28.77  ? 255 ALA A N    1 
ATOM   1829 C CA   . ALA A 1 268 ? -5.638  -17.895 -36.150 1.00 28.00  ? 255 ALA A CA   1 
ATOM   1830 C C    . ALA A 1 268 ? -5.306  -17.650 -37.623 1.00 29.91  ? 255 ALA A C    1 
ATOM   1831 O O    . ALA A 1 268 ? -5.646  -16.605 -38.180 1.00 31.27  ? 255 ALA A O    1 
ATOM   1832 C CB   . ALA A 1 268 ? -5.528  -16.609 -35.323 1.00 28.52  ? 255 ALA A CB   1 
ATOM   1833 N N    . GLY A 1 269 ? -4.659  -18.631 -38.285 1.00 29.33  ? 256 GLY A N    1 
ATOM   1834 C CA   . GLY A 1 269 ? -4.407  -18.496 -39.717 1.00 25.92  ? 256 GLY A CA   1 
ATOM   1835 C C    . GLY A 1 269 ? -3.082  -17.793 -40.093 1.00 23.44  ? 256 GLY A C    1 
ATOM   1836 O O    . GLY A 1 269 ? -2.802  -17.628 -41.284 1.00 25.03  ? 256 GLY A O    1 
ATOM   1837 N N    . LEU A 1 270 ? -2.215  -17.506 -39.117 1.00 22.27  ? 257 LEU A N    1 
ATOM   1838 C CA   . LEU A 1 270 ? -0.987  -16.753 -39.380 1.00 26.00  ? 257 LEU A CA   1 
ATOM   1839 C C    . LEU A 1 270 ? -0.061  -17.504 -40.347 1.00 27.23  ? 257 LEU A C    1 
ATOM   1840 O O    . LEU A 1 270 ? 0.687   -16.874 -41.093 1.00 19.68  ? 257 LEU A O    1 
ATOM   1841 C CB   . LEU A 1 270 ? -0.258  -16.393 -38.083 1.00 23.80  ? 257 LEU A CB   1 
ATOM   1842 C CG   . LEU A 1 270 ? 0.901   -15.393 -38.172 1.00 26.09  ? 257 LEU A CG   1 
ATOM   1843 C CD1  . LEU A 1 270 ? 0.453   -14.098 -38.803 1.00 26.46  ? 257 LEU A CD1  1 
ATOM   1844 C CD2  . LEU A 1 270 ? 1.537   -15.136 -36.776 1.00 22.13  ? 257 LEU A CD2  1 
ATOM   1845 N N    . SER A 1 271 ? -0.111  -18.847 -40.331 1.00 22.65  ? 258 SER A N    1 
ATOM   1846 C CA   . SER A 1 271 ? 0.812   -19.654 -41.149 1.00 20.28  ? 258 SER A CA   1 
ATOM   1847 C C    . SER A 1 271 ? 0.334   -19.788 -42.600 1.00 21.96  ? 258 SER A C    1 
ATOM   1848 O O    . SER A 1 271 ? 1.005   -20.402 -43.420 1.00 21.01  ? 258 SER A O    1 
ATOM   1849 C CB   . SER A 1 271 ? 0.983   -21.042 -40.497 1.00 18.65  ? 258 SER A CB   1 
ATOM   1850 O OG   . SER A 1 271 ? -0.275  -21.702 -40.661 1.00 20.32  ? 258 SER A OG   1 
ATOM   1851 N N    . ILE A 1 272 ? -0.880  -19.307 -42.915 1.00 25.05  ? 259 ILE A N    1 
ATOM   1852 C CA   . ILE A 1 272 ? -1.430  -19.435 -44.267 1.00 27.99  ? 259 ILE A CA   1 
ATOM   1853 C C    . ILE A 1 272 ? -1.654  -18.055 -44.910 1.00 27.51  ? 259 ILE A C    1 
ATOM   1854 O O    . ILE A 1 272 ? -2.737  -17.495 -44.808 1.00 30.74  ? 259 ILE A O    1 
ATOM   1855 C CB   . ILE A 1 272 ? -2.723  -20.259 -44.236 1.00 25.82  ? 259 ILE A CB   1 
ATOM   1856 C CG1  . ILE A 1 272 ? -2.455  -21.665 -43.651 1.00 27.57  ? 259 ILE A CG1  1 
ATOM   1857 C CG2  . ILE A 1 272 ? -3.330  -20.337 -45.642 1.00 26.97  ? 259 ILE A CG2  1 
ATOM   1858 C CD1  . ILE A 1 272 ? -3.702  -22.561 -43.643 1.00 28.16  ? 259 ILE A CD1  1 
ATOM   1859 N N    . GLN A 1 273 ? -0.627  -17.513 -45.565 1.00 25.81  ? 260 GLN A N    1 
ATOM   1860 C CA   . GLN A 1 273 ? -0.671  -16.115 -45.992 1.00 33.96  ? 260 GLN A CA   1 
ATOM   1861 C C    . GLN A 1 273 ? -0.349  -15.994 -47.490 1.00 40.86  ? 260 GLN A C    1 
ATOM   1862 O O    . GLN A 1 273 ? -0.942  -15.078 -48.117 1.00 37.02  ? 260 GLN A O    1 
ATOM   1863 C CB   . GLN A 1 273 ? 0.373   -15.267 -45.275 1.00 33.61  ? 260 GLN A CB   1 
ATOM   1864 C CG   . GLN A 1 273 ? -0.007  -14.934 -43.843 1.00 34.84  ? 260 GLN A CG   1 
ATOM   1865 C CD   . GLN A 1 273 ? 0.904   -13.905 -43.236 1.00 39.68  ? 260 GLN A CD   1 
ATOM   1866 O OE1  . GLN A 1 273 ? 1.079   -12.825 -43.798 1.00 39.18  ? 260 GLN A OE1  1 
ATOM   1867 N NE2  . GLN A 1 273 ? 1.489   -14.214 -42.082 1.00 34.37  ? 260 GLN A NE2  1 
ATOM   1868 O OXT  . GLN A 1 273 ? 0.485   -16.815 -47.976 1.00 36.98  ? 260 GLN A OXT  1 
ATOM   1869 N N    . SER B 1 11  ? -31.544 -40.133 -24.342 1.00 58.78  ? -2  SER B N    1 
ATOM   1870 C CA   . SER B 1 11  ? -31.951 -41.550 -24.147 1.00 53.52  ? -2  SER B CA   1 
ATOM   1871 C C    . SER B 1 11  ? -30.704 -42.422 -24.038 1.00 53.26  ? -2  SER B C    1 
ATOM   1872 O O    . SER B 1 11  ? -29.827 -42.367 -24.895 1.00 51.68  ? -2  SER B O    1 
ATOM   1873 C CB   . SER B 1 11  ? -32.868 -42.035 -25.254 1.00 55.84  ? -2  SER B CB   1 
ATOM   1874 N N    . SER B 1 12  ? -30.686 -43.275 -23.009 1.00 45.07  ? -1  SER B N    1 
ATOM   1875 C CA   . SER B 1 12  ? -29.505 -43.972 -22.531 1.00 39.20  ? -1  SER B CA   1 
ATOM   1876 C C    . SER B 1 12  ? -29.168 -45.142 -23.449 1.00 37.55  ? -1  SER B C    1 
ATOM   1877 O O    . SER B 1 12  ? -28.215 -45.885 -23.196 1.00 37.01  ? -1  SER B O    1 
ATOM   1878 C CB   . SER B 1 12  ? -29.778 -44.465 -21.132 1.00 38.86  ? -1  SER B CB   1 
ATOM   1879 O OG   . SER B 1 12  ? -30.806 -45.464 -21.162 1.00 35.95  ? -1  SER B OG   1 
ATOM   1880 N N    . GLY B 1 13  ? -30.015 -45.374 -24.466 1.00 36.38  ? 0   GLY B N    1 
ATOM   1881 C CA   . GLY B 1 13  ? -29.697 -46.365 -25.489 1.00 38.28  ? 0   GLY B CA   1 
ATOM   1882 C C    . GLY B 1 13  ? -28.809 -45.783 -26.597 1.00 40.50  ? 0   GLY B C    1 
ATOM   1883 O O    . GLY B 1 13  ? -28.157 -46.537 -27.320 1.00 37.03  ? 0   GLY B O    1 
ATOM   1884 N N    . MET B 1 14  ? -28.795 -44.439 -26.707 1.00 41.88  ? 1   MET B N    1 
ATOM   1885 C CA   . MET B 1 14  ? -27.965 -43.707 -27.669 1.00 45.39  ? 1   MET B CA   1 
ATOM   1886 C C    . MET B 1 14  ? -26.664 -43.198 -27.017 1.00 46.20  ? 1   MET B C    1 
ATOM   1887 O O    . MET B 1 14  ? -26.673 -42.449 -26.037 1.00 39.92  ? 1   MET B O    1 
ATOM   1888 C CB   . MET B 1 14  ? -28.745 -42.572 -28.360 1.00 36.37  ? 1   MET B CB   1 
ATOM   1889 N N    . ASN B 1 15  ? -25.537 -43.603 -27.624 1.00 36.69  ? 2   ASN B N    1 
ATOM   1890 C CA   . ASN B 1 15  ? -24.167 -43.251 -27.281 1.00 42.68  ? 2   ASN B CA   1 
ATOM   1891 C C    . ASN B 1 15  ? -24.006 -41.721 -27.144 1.00 44.96  ? 2   ASN B C    1 
ATOM   1892 O O    . ASN B 1 15  ? -24.470 -40.952 -27.976 1.00 38.87  ? 2   ASN B O    1 
ATOM   1893 C CB   . ASN B 1 15  ? -23.289 -43.940 -28.325 1.00 45.71  ? 2   ASN B CB   1 
ATOM   1894 C CG   . ASN B 1 15  ? -21.831 -44.048 -27.957 1.00 51.42  ? 2   ASN B CG   1 
ATOM   1895 O OD1  . ASN B 1 15  ? -21.365 -43.370 -27.037 1.00 51.90  ? 2   ASN B OD1  1 
ATOM   1896 N ND2  . ASN B 1 15  ? -21.071 -44.837 -28.700 1.00 45.11  ? 2   ASN B ND2  1 
ATOM   1897 N N    . ARG B 1 16  ? -23.425 -41.262 -26.035 1.00 45.91  ? 3   ARG B N    1 
ATOM   1898 C CA   . ARG B 1 16  ? -23.097 -39.853 -25.813 1.00 50.09  ? 3   ARG B CA   1 
ATOM   1899 C C    . ARG B 1 16  ? -21.715 -39.526 -26.409 1.00 42.98  ? 3   ARG B C    1 
ATOM   1900 O O    . ARG B 1 16  ? -21.374 -38.350 -26.596 1.00 35.36  ? 3   ARG B O    1 
ATOM   1901 C CB   . ARG B 1 16  ? -23.096 -39.543 -24.303 1.00 44.56  ? 3   ARG B CB   1 
ATOM   1902 C CG   . ARG B 1 16  ? -24.306 -39.758 -23.405 1.00 52.89  ? 3   ARG B CG   1 
ATOM   1903 C CD   . ARG B 1 16  ? -24.143 -39.175 -21.993 1.00 52.82  ? 3   ARG B CD   1 
ATOM   1904 N N    . HIS B 1 17  ? -20.915 -40.591 -26.641 1.00 37.71  ? 4   HIS B N    1 
ATOM   1905 C CA   . HIS B 1 17  ? -19.613 -40.585 -27.311 1.00 38.91  ? 4   HIS B CA   1 
ATOM   1906 C C    . HIS B 1 17  ? -18.452 -40.140 -26.416 1.00 37.54  ? 4   HIS B C    1 
ATOM   1907 O O    . HIS B 1 17  ? -17.335 -40.642 -26.558 1.00 37.34  ? 4   HIS B O    1 
ATOM   1908 C CB   . HIS B 1 17  ? -19.658 -39.830 -28.650 1.00 40.64  ? 4   HIS B CB   1 
ATOM   1909 C CG   . HIS B 1 17  ? -20.613 -40.510 -29.575 1.00 36.71  ? 4   HIS B CG   1 
ATOM   1910 N ND1  . HIS B 1 17  ? -20.281 -41.713 -30.170 1.00 29.16  ? 4   HIS B ND1  1 
ATOM   1911 C CD2  . HIS B 1 17  ? -21.859 -40.218 -29.946 1.00 33.92  ? 4   HIS B CD2  1 
ATOM   1912 C CE1  . HIS B 1 17  ? -21.300 -42.129 -30.906 1.00 27.44  ? 4   HIS B CE1  1 
ATOM   1913 N NE2  . HIS B 1 17  ? -22.271 -41.232 -30.786 1.00 33.24  ? 4   HIS B NE2  1 
ATOM   1914 N N    . THR B 1 18  ? -18.695 -39.175 -25.526 1.00 31.56  ? 5   THR B N    1 
ATOM   1915 C CA   . THR B 1 18  ? -17.657 -38.733 -24.603 1.00 36.34  ? 5   THR B CA   1 
ATOM   1916 C C    . THR B 1 18  ? -18.293 -38.437 -23.249 1.00 32.90  ? 5   THR B C    1 
ATOM   1917 O O    . THR B 1 18  ? -19.479 -38.150 -23.191 1.00 35.79  ? 5   THR B O    1 
ATOM   1918 C CB   . THR B 1 18  ? -16.939 -37.487 -25.153 1.00 30.40  ? 5   THR B CB   1 
ATOM   1919 O OG1  . THR B 1 18  ? -15.930 -37.211 -24.190 1.00 32.81  ? 5   THR B OG1  1 
ATOM   1920 C CG2  . THR B 1 18  ? -17.827 -36.261 -25.264 1.00 30.01  ? 5   THR B CG2  1 
ATOM   1921 N N    . ASP B 1 19  ? -17.471 -38.449 -22.196 1.00 29.72  ? 6   ASP B N    1 
ATOM   1922 C CA   . ASP B 1 19  ? -17.893 -37.979 -20.885 1.00 34.98  ? 6   ASP B CA   1 
ATOM   1923 C C    . ASP B 1 19  ? -17.526 -36.505 -20.720 1.00 36.16  ? 6   ASP B C    1 
ATOM   1924 O O    . ASP B 1 19  ? -17.910 -35.889 -19.727 1.00 35.17  ? 6   ASP B O    1 
ATOM   1925 C CB   . ASP B 1 19  ? -17.408 -38.885 -19.761 1.00 41.13  ? 6   ASP B CB   1 
ATOM   1926 C CG   . ASP B 1 19  ? -15.917 -39.197 -19.757 1.00 51.14  ? 6   ASP B CG   1 
ATOM   1927 O OD1  . ASP B 1 19  ? -15.216 -38.794 -20.721 1.00 64.93  ? 6   ASP B OD1  1 
ATOM   1928 O OD2  . ASP B 1 19  ? -15.439 -39.815 -18.777 1.00 47.36  ? 6   ASP B OD2  1 
ATOM   1929 N N    . THR B 1 20  ? -16.807 -35.915 -21.687 1.00 33.54  ? 7   THR B N    1 
ATOM   1930 C CA   . THR B 1 20  ? -16.429 -34.513 -21.552 1.00 33.41  ? 7   THR B CA   1 
ATOM   1931 C C    . THR B 1 20  ? -17.664 -33.632 -21.617 1.00 32.47  ? 7   THR B C    1 
ATOM   1932 O O    . THR B 1 20  ? -18.586 -33.934 -22.367 1.00 35.68  ? 7   THR B O    1 
ATOM   1933 C CB   . THR B 1 20  ? -15.458 -34.151 -22.673 1.00 32.90  ? 7   THR B CB   1 
ATOM   1934 O OG1  . THR B 1 20  ? -14.345 -34.979 -22.362 1.00 34.17  ? 7   THR B OG1  1 
ATOM   1935 C CG2  . THR B 1 20  ? -15.028 -32.694 -22.630 1.00 33.34  ? 7   THR B CG2  1 
ATOM   1936 N N    . HIS B 1 21  ? -17.635 -32.488 -20.929 1.00 38.86  ? 8   HIS B N    1 
ATOM   1937 C CA   . HIS B 1 21  ? -18.739 -31.546 -21.000 1.00 33.17  ? 8   HIS B CA   1 
ATOM   1938 C C    . HIS B 1 21  ? -18.245 -30.200 -21.517 1.00 32.56  ? 8   HIS B C    1 
ATOM   1939 O O    . HIS B 1 21  ? -17.392 -29.583 -20.905 1.00 30.19  ? 8   HIS B O    1 
ATOM   1940 C CB   . HIS B 1 21  ? -19.445 -31.398 -19.635 1.00 38.52  ? 8   HIS B CB   1 
ATOM   1941 C CG   . HIS B 1 21  ? -20.517 -30.341 -19.634 1.00 52.25  ? 8   HIS B CG   1 
ATOM   1942 N ND1  . HIS B 1 21  ? -20.603 -29.340 -18.681 1.00 56.13  ? 8   HIS B ND1  1 
ATOM   1943 C CD2  . HIS B 1 21  ? -21.501 -30.083 -20.528 1.00 49.93  ? 8   HIS B CD2  1 
ATOM   1944 C CE1  . HIS B 1 21  ? -21.619 -28.535 -18.976 1.00 55.57  ? 8   HIS B CE1  1 
ATOM   1945 N NE2  . HIS B 1 21  ? -22.169 -28.967 -20.095 1.00 58.68  ? 8   HIS B NE2  1 
ATOM   1946 N N    . TYR B 1 22  ? -18.828 -29.749 -22.638 1.00 32.86  ? 9   TYR B N    1 
ATOM   1947 C CA   . TYR B 1 22  ? -18.481 -28.470 -23.228 1.00 34.03  ? 9   TYR B CA   1 
ATOM   1948 C C    . TYR B 1 22  ? -19.633 -27.504 -23.002 1.00 30.08  ? 9   TYR B C    1 
ATOM   1949 O O    . TYR B 1 22  ? -20.553 -27.467 -23.797 1.00 33.52  ? 9   TYR B O    1 
ATOM   1950 C CB   . TYR B 1 22  ? -18.145 -28.529 -24.722 1.00 32.88  ? 9   TYR B CB   1 
ATOM   1951 C CG   . TYR B 1 22  ? -16.978 -29.420 -25.139 1.00 31.86  ? 9   TYR B CG   1 
ATOM   1952 C CD1  . TYR B 1 22  ? -17.146 -30.793 -25.320 1.00 29.40  ? 9   TYR B CD1  1 
ATOM   1953 C CD2  . TYR B 1 22  ? -15.726 -28.867 -25.415 1.00 33.61  ? 9   TYR B CD2  1 
ATOM   1954 C CE1  . TYR B 1 22  ? -16.101 -31.590 -25.758 1.00 30.12  ? 9   TYR B CE1  1 
ATOM   1955 C CE2  . TYR B 1 22  ? -14.667 -29.647 -25.844 1.00 30.07  ? 9   TYR B CE2  1 
ATOM   1956 C CZ   . TYR B 1 22  ? -14.864 -31.005 -26.017 1.00 33.70  ? 9   TYR B CZ   1 
ATOM   1957 O OH   . TYR B 1 22  ? -13.811 -31.767 -26.413 1.00 34.22  ? 9   TYR B OH   1 
ATOM   1958 N N    . PRO B 1 23  ? -19.580 -26.660 -21.959 1.00 36.90  ? 10  PRO B N    1 
ATOM   1959 C CA   . PRO B 1 23  ? -20.630 -25.669 -21.735 1.00 41.61  ? 10  PRO B CA   1 
ATOM   1960 C C    . PRO B 1 23  ? -20.919 -24.788 -22.952 1.00 42.01  ? 10  PRO B C    1 
ATOM   1961 O O    . PRO B 1 23  ? -22.095 -24.484 -23.208 1.00 39.59  ? 10  PRO B O    1 
ATOM   1962 C CB   . PRO B 1 23  ? -20.198 -24.866 -20.501 1.00 35.51  ? 10  PRO B CB   1 
ATOM   1963 C CG   . PRO B 1 23  ? -19.091 -25.720 -19.896 1.00 39.84  ? 10  PRO B CG   1 
ATOM   1964 C CD   . PRO B 1 23  ? -18.506 -26.610 -20.953 1.00 37.65  ? 10  PRO B CD   1 
ATOM   1965 N N    . SER B 1 24  ? -19.873 -24.410 -23.709 1.00 32.59  ? 11  SER B N    1 
ATOM   1966 C CA   . SER B 1 24  ? -20.049 -23.520 -24.862 1.00 31.25  ? 11  SER B CA   1 
ATOM   1967 C C    . SER B 1 24  ? -20.908 -24.144 -25.979 1.00 34.58  ? 11  SER B C    1 
ATOM   1968 O O    . SER B 1 24  ? -21.305 -23.442 -26.916 1.00 30.03  ? 11  SER B O    1 
ATOM   1969 C CB   . SER B 1 24  ? -18.697 -23.075 -25.423 1.00 32.17  ? 11  SER B CB   1 
ATOM   1970 O OG   . SER B 1 24  ? -17.936 -24.248 -25.722 1.00 36.06  ? 11  SER B OG   1 
ATOM   1971 N N    . LEU B 1 25  ? -21.150 -25.471 -25.929 1.00 30.14  ? 12  LEU B N    1 
ATOM   1972 C CA   . LEU B 1 25  ? -21.945 -26.133 -26.964 1.00 31.76  ? 12  LEU B CA   1 
ATOM   1973 C C    . LEU B 1 25  ? -23.457 -26.091 -26.689 1.00 38.06  ? 12  LEU B C    1 
ATOM   1974 O O    . LEU B 1 25  ? -24.272 -26.221 -27.607 1.00 34.52  ? 12  LEU B O    1 
ATOM   1975 C CB   . LEU B 1 25  ? -21.443 -27.568 -27.168 1.00 35.26  ? 12  LEU B CB   1 
ATOM   1976 C CG   . LEU B 1 25  ? -20.087 -27.684 -27.883 1.00 32.71  ? 12  LEU B CG   1 
ATOM   1977 C CD1  . LEU B 1 25  ? -19.808 -29.159 -28.169 1.00 29.97  ? 12  LEU B CD1  1 
ATOM   1978 C CD2  . LEU B 1 25  ? -20.105 -26.880 -29.191 1.00 27.49  ? 12  LEU B CD2  1 
ATOM   1979 N N    . ALA B 1 26  ? -23.848 -25.946 -25.418 1.00 36.67  ? 13  ALA B N    1 
ATOM   1980 C CA   . ALA B 1 26  ? -25.256 -25.891 -25.049 1.00 37.59  ? 13  ALA B CA   1 
ATOM   1981 C C    . ALA B 1 26  ? -25.997 -24.847 -25.895 1.00 39.24  ? 13  ALA B C    1 
ATOM   1982 O O    . ALA B 1 26  ? -25.549 -23.691 -25.996 1.00 38.95  ? 13  ALA B O    1 
ATOM   1983 C CB   . ALA B 1 26  ? -25.371 -25.591 -23.564 1.00 38.43  ? 13  ALA B CB   1 
ATOM   1984 N N    . ASP B 1 27  ? -27.130 -25.261 -26.501 1.00 38.18  ? 14  ASP B N    1 
ATOM   1985 C CA   . ASP B 1 27  ? -28.004 -24.323 -27.215 1.00 40.76  ? 14  ASP B CA   1 
ATOM   1986 C C    . ASP B 1 27  ? -27.503 -23.973 -28.621 1.00 45.57  ? 14  ASP B C    1 
ATOM   1987 O O    . ASP B 1 27  ? -28.190 -23.267 -29.364 1.00 44.06  ? 14  ASP B O    1 
ATOM   1988 C CB   . ASP B 1 27  ? -28.168 -22.973 -26.517 1.00 35.94  ? 14  ASP B CB   1 
ATOM   1989 N N    . LYS B 1 28  ? -26.289 -24.395 -28.983 1.00 47.72  ? 15  LYS B N    1 
ATOM   1990 C CA   . LYS B 1 28  ? -25.747 -23.990 -30.273 1.00 42.11  ? 15  LYS B CA   1 
ATOM   1991 C C    . LYS B 1 28  ? -26.493 -24.753 -31.361 1.00 37.82  ? 15  LYS B C    1 
ATOM   1992 O O    . LYS B 1 28  ? -26.842 -25.918 -31.145 1.00 43.88  ? 15  LYS B O    1 
ATOM   1993 C CB   . LYS B 1 28  ? -24.232 -24.231 -30.332 1.00 39.09  ? 15  LYS B CB   1 
ATOM   1994 C CG   . LYS B 1 28  ? -23.373 -23.335 -29.445 1.00 48.25  ? 15  LYS B CG   1 
ATOM   1995 C CD   . LYS B 1 28  ? -23.202 -21.903 -29.959 1.00 54.02  ? 15  LYS B CD   1 
ATOM   1996 C CE   . LYS B 1 28  ? -22.707 -20.915 -28.936 1.00 59.22  ? 15  LYS B CE   1 
ATOM   1997 N NZ   . LYS B 1 28  ? -21.453 -21.347 -28.314 1.00 65.58  ? 15  LYS B NZ   1 
ATOM   1998 N N    . VAL B 1 29  ? -26.680 -24.094 -32.517 1.00 38.01  ? 16  VAL B N    1 
ATOM   1999 C CA   . VAL B 1 29  ? -27.345 -24.667 -33.688 1.00 37.20  ? 16  VAL B CA   1 
ATOM   2000 C C    . VAL B 1 29  ? -26.308 -25.356 -34.574 1.00 30.24  ? 16  VAL B C    1 
ATOM   2001 O O    . VAL B 1 29  ? -25.453 -24.707 -35.181 1.00 34.68  ? 16  VAL B O    1 
ATOM   2002 C CB   . VAL B 1 29  ? -28.115 -23.581 -34.479 1.00 39.80  ? 16  VAL B CB   1 
ATOM   2003 C CG1  . VAL B 1 29  ? -28.798 -24.126 -35.732 1.00 41.43  ? 16  VAL B CG1  1 
ATOM   2004 C CG2  . VAL B 1 29  ? -29.134 -22.841 -33.607 1.00 36.26  ? 16  VAL B CG2  1 
ATOM   2005 N N    . VAL B 1 30  ? -26.430 -26.681 -34.672 1.00 34.01  ? 17  VAL B N    1 
ATOM   2006 C CA   . VAL B 1 30  ? -25.509 -27.524 -35.415 1.00 34.01  ? 17  VAL B CA   1 
ATOM   2007 C C    . VAL B 1 30  ? -26.255 -28.135 -36.605 1.00 36.79  ? 17  VAL B C    1 
ATOM   2008 O O    . VAL B 1 30  ? -27.347 -28.673 -36.432 1.00 41.16  ? 17  VAL B O    1 
ATOM   2009 C CB   . VAL B 1 30  ? -24.952 -28.596 -34.456 1.00 32.23  ? 17  VAL B CB   1 
ATOM   2010 C CG1  . VAL B 1 30  ? -24.035 -29.600 -35.160 1.00 31.43  ? 17  VAL B CG1  1 
ATOM   2011 C CG2  . VAL B 1 30  ? -24.192 -27.947 -33.304 1.00 33.26  ? 17  VAL B CG2  1 
ATOM   2012 N N    . LEU B 1 31  ? -25.641 -28.084 -37.795 1.00 32.68  ? 18  LEU B N    1 
ATOM   2013 C CA   . LEU B 1 31  ? -26.180 -28.691 -39.002 1.00 29.89  ? 18  LEU B CA   1 
ATOM   2014 C C    . LEU B 1 31  ? -25.199 -29.708 -39.592 1.00 30.85  ? 18  LEU B C    1 
ATOM   2015 O O    . LEU B 1 31  ? -24.052 -29.373 -39.852 1.00 33.83  ? 18  LEU B O    1 
ATOM   2016 C CB   . LEU B 1 31  ? -26.470 -27.566 -39.984 1.00 28.28  ? 18  LEU B CB   1 
ATOM   2017 C CG   . LEU B 1 31  ? -27.021 -28.029 -41.344 1.00 34.03  ? 18  LEU B CG   1 
ATOM   2018 C CD1  . LEU B 1 31  ? -28.315 -28.894 -41.257 1.00 31.45  ? 18  LEU B CD1  1 
ATOM   2019 C CD2  . LEU B 1 31  ? -27.189 -26.813 -42.268 1.00 28.11  ? 18  LEU B CD2  1 
ATOM   2020 N N    . ILE B 1 32  ? -25.654 -30.935 -39.834 1.00 31.85  ? 19  ILE B N    1 
ATOM   2021 C CA   . ILE B 1 32  ? -24.784 -32.017 -40.282 1.00 33.05  ? 19  ILE B CA   1 
ATOM   2022 C C    . ILE B 1 32  ? -25.423 -32.733 -41.470 1.00 41.56  ? 19  ILE B C    1 
ATOM   2023 O O    . ILE B 1 32  ? -26.569 -33.159 -41.387 1.00 37.62  ? 19  ILE B O    1 
ATOM   2024 C CB   . ILE B 1 32  ? -24.580 -33.031 -39.157 1.00 33.16  ? 19  ILE B CB   1 
ATOM   2025 C CG1  . ILE B 1 32  ? -23.889 -32.377 -37.951 1.00 31.19  ? 19  ILE B CG1  1 
ATOM   2026 C CG2  . ILE B 1 32  ? -23.803 -34.240 -39.678 1.00 33.73  ? 19  ILE B CG2  1 
ATOM   2027 C CD1  . ILE B 1 32  ? -24.247 -33.046 -36.647 1.00 34.43  ? 19  ILE B CD1  1 
ATOM   2028 N N    . SER B 1 33  ? -24.663 -32.880 -42.561 1.00 35.47  ? 20  SER B N    1 
ATOM   2029 C CA   . SER B 1 33  ? -25.141 -33.525 -43.763 1.00 31.46  ? 20  SER B CA   1 
ATOM   2030 C C    . SER B 1 33  ? -24.721 -34.986 -43.691 1.00 36.91  ? 20  SER B C    1 
ATOM   2031 O O    . SER B 1 33  ? -23.768 -35.304 -42.972 1.00 36.63  ? 20  SER B O    1 
ATOM   2032 C CB   . SER B 1 33  ? -24.629 -32.787 -44.994 1.00 40.81  ? 20  SER B CB   1 
ATOM   2033 O OG   . SER B 1 33  ? -23.208 -32.868 -45.128 1.00 34.75  ? 20  SER B OG   1 
ATOM   2034 N N    . GLY B 1 34  ? -25.513 -35.878 -44.317 1.00 34.65  ? 21  GLY B N    1 
ATOM   2035 C CA   . GLY B 1 34  ? -25.312 -37.316 -44.190 1.00 35.69  ? 21  GLY B CA   1 
ATOM   2036 C C    . GLY B 1 34  ? -25.389 -37.770 -42.730 1.00 36.50  ? 21  GLY B C    1 
ATOM   2037 O O    . GLY B 1 34  ? -24.627 -38.645 -42.319 1.00 43.94  ? 21  GLY B O    1 
ATOM   2038 N N    . GLY B 1 35  ? -26.349 -37.201 -41.985 1.00 35.11  ? 22  GLY B N    1 
ATOM   2039 C CA   . GLY B 1 35  ? -26.455 -37.274 -40.531 1.00 37.78  ? 22  GLY B CA   1 
ATOM   2040 C C    . GLY B 1 35  ? -27.149 -38.534 -39.999 1.00 38.72  ? 22  GLY B C    1 
ATOM   2041 O O    . GLY B 1 35  ? -27.198 -38.716 -38.781 1.00 35.88  ? 22  GLY B O    1 
ATOM   2042 N N    . ALA B 1 36  ? -27.686 -39.396 -40.869 1.00 33.46  ? 23  ALA B N    1 
ATOM   2043 C CA   . ALA B 1 36  ? -28.599 -40.419 -40.369 1.00 35.74  ? 23  ALA B CA   1 
ATOM   2044 C C    . ALA B 1 36  ? -27.894 -41.767 -40.241 1.00 36.27  ? 23  ALA B C    1 
ATOM   2045 O O    . ALA B 1 36  ? -28.510 -42.747 -39.843 1.00 38.05  ? 23  ALA B O    1 
ATOM   2046 C CB   . ALA B 1 36  ? -29.827 -40.552 -41.277 1.00 33.21  ? 23  ALA B CB   1 
ATOM   2047 N N    . SER B 1 37  ? -26.634 -41.859 -40.650 1.00 39.40  ? 24  SER B N    1 
ATOM   2048 C CA   . SER B 1 37  ? -25.924 -43.118 -40.495 1.00 41.37  ? 24  SER B CA   1 
ATOM   2049 C C    . SER B 1 37  ? -24.469 -42.843 -40.145 1.00 40.04  ? 24  SER B C    1 
ATOM   2050 O O    . SER B 1 37  ? -24.023 -41.712 -40.300 1.00 39.58  ? 24  SER B O    1 
ATOM   2051 C CB   . SER B 1 37  ? -26.044 -43.985 -41.731 1.00 45.29  ? 24  SER B CB   1 
ATOM   2052 O OG   . SER B 1 37  ? -25.250 -43.491 -42.803 1.00 43.15  ? 24  SER B OG   1 
ATOM   2053 N N    . GLY B 1 38  ? -23.767 -43.890 -39.688 1.00 42.15  ? 25  GLY B N    1 
ATOM   2054 C CA   . GLY B 1 38  ? -22.315 -43.937 -39.545 1.00 41.70  ? 25  GLY B CA   1 
ATOM   2055 C C    . GLY B 1 38  ? -21.771 -42.742 -38.764 1.00 40.92  ? 25  GLY B C    1 
ATOM   2056 O O    . GLY B 1 38  ? -22.274 -42.410 -37.687 1.00 38.94  ? 25  GLY B O    1 
ATOM   2057 N N    . ILE B 1 39  ? -20.759 -42.082 -39.349 1.00 36.92  ? 26  ILE B N    1 
ATOM   2058 C CA   . ILE B 1 39  ? -20.049 -40.997 -38.688 1.00 32.18  ? 26  ILE B CA   1 
ATOM   2059 C C    . ILE B 1 39  ? -21.011 -39.836 -38.444 1.00 29.31  ? 26  ILE B C    1 
ATOM   2060 O O    . ILE B 1 39  ? -21.040 -39.297 -37.341 1.00 34.32  ? 26  ILE B O    1 
ATOM   2061 C CB   . ILE B 1 39  ? -18.807 -40.585 -39.493 1.00 33.45  ? 26  ILE B CB   1 
ATOM   2062 C CG1  . ILE B 1 39  ? -17.873 -41.802 -39.683 1.00 36.46  ? 26  ILE B CG1  1 
ATOM   2063 C CG2  . ILE B 1 39  ? -18.122 -39.371 -38.866 1.00 35.51  ? 26  ILE B CG2  1 
ATOM   2064 C CD1  . ILE B 1 39  ? -16.621 -41.525 -40.505 1.00 31.22  ? 26  ILE B CD1  1 
ATOM   2065 N N    . GLY B 1 40  ? -21.853 -39.528 -39.428 1.00 31.37  ? 27  GLY B N    1 
ATOM   2066 C CA   . GLY B 1 40  ? -22.782 -38.402 -39.319 1.00 35.17  ? 27  GLY B CA   1 
ATOM   2067 C C    . GLY B 1 40  ? -23.783 -38.602 -38.175 1.00 42.26  ? 27  GLY B C    1 
ATOM   2068 O O    . GLY B 1 40  ? -24.161 -37.643 -37.485 1.00 31.83  ? 27  GLY B O    1 
ATOM   2069 N N    . ARG B 1 41  ? -24.201 -39.867 -37.986 1.00 32.40  ? 28  ARG B N    1 
ATOM   2070 C CA   . ARG B 1 41  ? -25.139 -40.207 -36.926 1.00 38.90  ? 28  ARG B CA   1 
ATOM   2071 C C    . ARG B 1 41  ? -24.460 -39.953 -35.591 1.00 30.85  ? 28  ARG B C    1 
ATOM   2072 O O    . ARG B 1 41  ? -25.066 -39.394 -34.683 1.00 32.79  ? 28  ARG B O    1 
ATOM   2073 C CB   . ARG B 1 41  ? -25.676 -41.649 -37.034 1.00 40.41  ? 28  ARG B CB   1 
ATOM   2074 C CG   . ARG B 1 41  ? -26.245 -42.210 -35.734 1.00 40.21  ? 28  ARG B CG   1 
ATOM   2075 C CD   . ARG B 1 41  ? -26.806 -43.610 -35.891 1.00 41.87  ? 28  ARG B CD   1 
ATOM   2076 N NE   . ARG B 1 41  ? -27.123 -44.142 -34.565 1.00 46.18  ? 28  ARG B NE   1 
ATOM   2077 C CZ   . ARG B 1 41  ? -28.009 -45.115 -34.336 1.00 53.57  ? 28  ARG B CZ   1 
ATOM   2078 N NH1  . ARG B 1 41  ? -28.475 -45.820 -35.346 1.00 47.54  ? 28  ARG B NH1  1 
ATOM   2079 N NH2  . ARG B 1 41  ? -28.423 -45.392 -33.106 1.00 47.40  ? 28  ARG B NH2  1 
ATOM   2080 N N    . ALA B 1 42  ? -23.196 -40.377 -35.497 1.00 36.45  ? 29  ALA B N    1 
ATOM   2081 C CA   . ALA B 1 42  ? -22.434 -40.179 -34.277 1.00 36.72  ? 29  ALA B CA   1 
ATOM   2082 C C    . ALA B 1 42  ? -22.267 -38.692 -33.954 1.00 35.15  ? 29  ALA B C    1 
ATOM   2083 O O    . ALA B 1 42  ? -22.356 -38.299 -32.801 1.00 33.86  ? 29  ALA B O    1 
ATOM   2084 C CB   . ALA B 1 42  ? -21.134 -40.946 -34.360 1.00 34.70  ? 29  ALA B CB   1 
ATOM   2085 N N    . PHE B 1 43  ? -22.037 -37.858 -34.973 1.00 38.32  ? 30  PHE B N    1 
ATOM   2086 C CA   . PHE B 1 43  ? -22.012 -36.423 -34.735 1.00 38.61  ? 30  PHE B CA   1 
ATOM   2087 C C    . PHE B 1 43  ? -23.325 -35.993 -34.106 1.00 39.48  ? 30  PHE B C    1 
ATOM   2088 O O    . PHE B 1 43  ? -23.330 -35.241 -33.128 1.00 41.21  ? 30  PHE B O    1 
ATOM   2089 C CB   . PHE B 1 43  ? -21.793 -35.594 -36.006 1.00 42.06  ? 30  PHE B CB   1 
ATOM   2090 C CG   . PHE B 1 43  ? -20.442 -35.801 -36.675 1.00 40.24  ? 30  PHE B CG   1 
ATOM   2091 C CD1  . PHE B 1 43  ? -19.289 -35.977 -35.900 1.00 40.98  ? 30  PHE B CD1  1 
ATOM   2092 C CD2  . PHE B 1 43  ? -20.321 -35.771 -38.062 1.00 38.58  ? 30  PHE B CD2  1 
ATOM   2093 C CE1  . PHE B 1 43  ? -18.052 -36.167 -36.515 1.00 44.40  ? 30  PHE B CE1  1 
ATOM   2094 C CE2  . PHE B 1 43  ? -19.089 -35.962 -38.673 1.00 34.42  ? 30  PHE B CE2  1 
ATOM   2095 C CZ   . PHE B 1 43  ? -17.952 -36.148 -37.895 1.00 39.84  ? 30  PHE B CZ   1 
ATOM   2096 N N    . VAL B 1 44  ? -24.439 -36.464 -34.692 1.00 39.61  ? 31  VAL B N    1 
ATOM   2097 C CA   . VAL B 1 44  ? -25.751 -35.985 -34.293 1.00 35.16  ? 31  VAL B CA   1 
ATOM   2098 C C    . VAL B 1 44  ? -25.985 -36.319 -32.825 1.00 32.06  ? 31  VAL B C    1 
ATOM   2099 O O    . VAL B 1 44  ? -26.385 -35.464 -32.040 1.00 29.04  ? 31  VAL B O    1 
ATOM   2100 C CB   . VAL B 1 44  ? -26.886 -36.494 -35.211 1.00 38.61  ? 31  VAL B CB   1 
ATOM   2101 C CG1  . VAL B 1 44  ? -28.250 -36.111 -34.668 1.00 36.12  ? 31  VAL B CG1  1 
ATOM   2102 C CG2  . VAL B 1 44  ? -26.747 -35.992 -36.651 1.00 31.33  ? 31  VAL B CG2  1 
ATOM   2103 N N    . GLU B 1 45  ? -25.680 -37.565 -32.459 1.00 30.79  ? 32  GLU B N    1 
ATOM   2104 C CA   . GLU B 1 45  ? -25.835 -38.041 -31.100 1.00 31.60  ? 32  GLU B CA   1 
ATOM   2105 C C    . GLU B 1 45  ? -24.951 -37.244 -30.143 1.00 40.34  ? 32  GLU B C    1 
ATOM   2106 O O    . GLU B 1 45  ? -25.427 -36.805 -29.084 1.00 45.58  ? 32  GLU B O    1 
ATOM   2107 C CB   . GLU B 1 45  ? -25.413 -39.509 -31.038 1.00 30.10  ? 32  GLU B CB   1 
ATOM   2108 C CG   . GLU B 1 45  ? -26.431 -40.434 -31.692 1.00 32.77  ? 32  GLU B CG   1 
ATOM   2109 C CD   . GLU B 1 45  ? -25.862 -41.832 -31.903 1.00 39.49  ? 32  GLU B CD   1 
ATOM   2110 O OE1  . GLU B 1 45  ? -24.627 -42.038 -31.865 1.00 36.33  ? 32  GLU B OE1  1 
ATOM   2111 O OE2  . GLU B 1 45  ? -26.679 -42.775 -32.066 1.00 43.33  ? 32  GLU B OE2  1 
ATOM   2112 N N    . ALA B 1 46  ? -23.666 -37.060 -30.515 1.00 34.33  ? 33  ALA B N    1 
ATOM   2113 C CA   . ALA B 1 46  ? -22.710 -36.427 -29.610 1.00 34.01  ? 33  ALA B CA   1 
ATOM   2114 C C    . ALA B 1 46  ? -23.125 -34.989 -29.303 1.00 29.11  ? 33  ALA B C    1 
ATOM   2115 O O    . ALA B 1 46  ? -23.028 -34.579 -28.152 1.00 36.83  ? 33  ALA B O    1 
ATOM   2116 C CB   . ALA B 1 46  ? -21.279 -36.538 -30.115 1.00 31.66  ? 33  ALA B CB   1 
ATOM   2117 N N    . PHE B 1 47  ? -23.625 -34.247 -30.291 1.00 29.41  ? 34  PHE B N    1 
ATOM   2118 C CA   . PHE B 1 47  ? -23.913 -32.830 -30.064 1.00 34.64  ? 34  PHE B CA   1 
ATOM   2119 C C    . PHE B 1 47  ? -25.221 -32.672 -29.308 1.00 43.93  ? 34  PHE B C    1 
ATOM   2120 O O    . PHE B 1 47  ? -25.408 -31.726 -28.523 1.00 39.85  ? 34  PHE B O    1 
ATOM   2121 C CB   . PHE B 1 47  ? -24.025 -32.083 -31.395 1.00 32.96  ? 34  PHE B CB   1 
ATOM   2122 C CG   . PHE B 1 47  ? -22.679 -31.625 -31.954 1.00 37.34  ? 34  PHE B CG   1 
ATOM   2123 C CD1  . PHE B 1 47  ? -22.151 -30.372 -31.616 1.00 37.55  ? 34  PHE B CD1  1 
ATOM   2124 C CD2  . PHE B 1 47  ? -21.928 -32.455 -32.788 1.00 33.84  ? 34  PHE B CD2  1 
ATOM   2125 C CE1  . PHE B 1 47  ? -20.919 -29.951 -32.130 1.00 37.08  ? 34  PHE B CE1  1 
ATOM   2126 C CE2  . PHE B 1 47  ? -20.697 -32.029 -33.290 1.00 33.44  ? 34  PHE B CE2  1 
ATOM   2127 C CZ   . PHE B 1 47  ? -20.188 -30.786 -32.943 1.00 34.26  ? 34  PHE B CZ   1 
ATOM   2128 N N    . VAL B 1 48  ? -26.143 -33.604 -29.600 1.00 42.62  ? 35  VAL B N    1 
ATOM   2129 C CA   . VAL B 1 48  ? -27.412 -33.653 -28.895 1.00 36.94  ? 35  VAL B CA   1 
ATOM   2130 C C    . VAL B 1 48  ? -27.097 -33.852 -27.417 1.00 37.77  ? 35  VAL B C    1 
ATOM   2131 O O    . VAL B 1 48  ? -27.622 -33.116 -26.556 1.00 35.21  ? 35  VAL B O    1 
ATOM   2132 C CB   . VAL B 1 48  ? -28.417 -34.676 -29.483 1.00 41.95  ? 35  VAL B CB   1 
ATOM   2133 C CG1  . VAL B 1 48  ? -29.511 -35.084 -28.509 1.00 40.61  ? 35  VAL B CG1  1 
ATOM   2134 C CG2  . VAL B 1 48  ? -29.050 -34.157 -30.768 1.00 37.77  ? 35  VAL B CG2  1 
ATOM   2135 N N    . ALA B 1 49  ? -26.174 -34.789 -27.147 1.00 32.03  ? 36  ALA B N    1 
ATOM   2136 C CA   . ALA B 1 49  ? -25.807 -35.114 -25.772 1.00 35.74  ? 36  ALA B CA   1 
ATOM   2137 C C    . ALA B 1 49  ? -25.131 -33.950 -25.059 1.00 36.61  ? 36  ALA B C    1 
ATOM   2138 O O    . ALA B 1 49  ? -25.015 -33.995 -23.835 1.00 40.48  ? 36  ALA B O    1 
ATOM   2139 C CB   . ALA B 1 49  ? -24.987 -36.395 -25.684 1.00 39.98  ? 36  ALA B CB   1 
ATOM   2140 N N    . GLN B 1 50  ? -24.684 -32.929 -25.811 1.00 37.63  ? 37  GLN B N    1 
ATOM   2141 C CA   . GLN B 1 50  ? -24.049 -31.745 -25.241 1.00 39.37  ? 37  GLN B CA   1 
ATOM   2142 C C    . GLN B 1 50  ? -25.051 -30.593 -25.126 1.00 41.00  ? 37  GLN B C    1 
ATOM   2143 O O    . GLN B 1 50  ? -24.676 -29.441 -24.795 1.00 33.60  ? 37  GLN B O    1 
ATOM   2144 C CB   . GLN B 1 50  ? -22.897 -31.246 -26.121 1.00 37.62  ? 37  GLN B CB   1 
ATOM   2145 C CG   . GLN B 1 50  ? -21.670 -32.158 -26.174 1.00 33.13  ? 37  GLN B CG   1 
ATOM   2146 C CD   . GLN B 1 50  ? -20.880 -32.239 -24.888 1.00 35.54  ? 37  GLN B CD   1 
ATOM   2147 O OE1  . GLN B 1 50  ? -20.672 -31.233 -24.184 1.00 31.93  ? 37  GLN B OE1  1 
ATOM   2148 N NE2  . GLN B 1 50  ? -20.420 -33.452 -24.598 1.00 29.18  ? 37  GLN B NE2  1 
ATOM   2149 N N    . GLY B 1 51  ? -26.317 -30.902 -25.463 1.00 35.32  ? 38  GLY B N    1 
ATOM   2150 C CA   . GLY B 1 51  ? -27.403 -29.938 -25.334 1.00 31.24  ? 38  GLY B CA   1 
ATOM   2151 C C    . GLY B 1 51  ? -27.434 -28.926 -26.475 1.00 34.32  ? 38  GLY B C    1 
ATOM   2152 O O    . GLY B 1 51  ? -28.038 -27.851 -26.361 1.00 37.58  ? 38  GLY B O    1 
ATOM   2153 N N    . SER B 1 52  ? -26.781 -29.266 -27.588 1.00 31.20  ? 39  SER B N    1 
ATOM   2154 C CA   . SER B 1 52  ? -26.959 -28.510 -28.821 1.00 35.32  ? 39  SER B CA   1 
ATOM   2155 C C    . SER B 1 52  ? -28.344 -28.777 -29.415 1.00 35.32  ? 39  SER B C    1 
ATOM   2156 O O    . SER B 1 52  ? -28.950 -29.824 -29.157 1.00 37.74  ? 39  SER B O    1 
ATOM   2157 C CB   . SER B 1 52  ? -25.874 -28.839 -29.833 1.00 33.53  ? 39  SER B CB   1 
ATOM   2158 O OG   . SER B 1 52  ? -24.589 -28.688 -29.241 1.00 36.31  ? 39  SER B OG   1 
ATOM   2159 N N    . ARG B 1 53  ? -28.804 -27.823 -30.235 1.00 33.90  ? 40  ARG B N    1 
ATOM   2160 C CA   . ARG B 1 53  ? -29.908 -28.005 -31.178 1.00 41.25  ? 40  ARG B CA   1 
ATOM   2161 C C    . ARG B 1 53  ? -29.355 -28.433 -32.547 1.00 42.97  ? 40  ARG B C    1 
ATOM   2162 O O    . ARG B 1 53  ? -28.770 -27.613 -33.260 1.00 37.92  ? 40  ARG B O    1 
ATOM   2163 C CB   . ARG B 1 53  ? -30.707 -26.694 -31.265 1.00 36.17  ? 40  ARG B CB   1 
ATOM   2164 C CG   . ARG B 1 53  ? -31.517 -26.382 -30.009 1.00 43.13  ? 40  ARG B CG   1 
ATOM   2165 C CD   . ARG B 1 53  ? -32.215 -25.011 -30.080 1.00 38.70  ? 40  ARG B CD   1 
ATOM   2166 N NE   . ARG B 1 53  ? -31.226 -23.922 -30.042 1.00 45.96  ? 40  ARG B NE   1 
ATOM   2167 C CZ   . ARG B 1 53  ? -31.414 -22.658 -30.451 1.00 45.78  ? 40  ARG B CZ   1 
ATOM   2168 N NH1  . ARG B 1 53  ? -32.528 -22.314 -31.063 1.00 47.70  ? 40  ARG B NH1  1 
ATOM   2169 N NH2  . ARG B 1 53  ? -30.473 -21.745 -30.292 1.00 47.11  ? 40  ARG B NH2  1 
ATOM   2170 N N    . VAL B 1 54  ? -29.572 -29.710 -32.903 1.00 36.23  ? 41  VAL B N    1 
ATOM   2171 C CA   . VAL B 1 54  ? -28.891 -30.349 -34.026 1.00 32.89  ? 41  VAL B CA   1 
ATOM   2172 C C    . VAL B 1 54  ? -29.898 -30.662 -35.142 1.00 40.44  ? 41  VAL B C    1 
ATOM   2173 O O    . VAL B 1 54  ? -30.830 -31.461 -34.945 1.00 37.78  ? 41  VAL B O    1 
ATOM   2174 C CB   . VAL B 1 54  ? -28.245 -31.645 -33.489 1.00 32.69  ? 41  VAL B CB   1 
ATOM   2175 C CG1  . VAL B 1 54  ? -27.486 -32.411 -34.561 1.00 31.86  ? 41  VAL B CG1  1 
ATOM   2176 C CG2  . VAL B 1 54  ? -27.359 -31.347 -32.287 1.00 30.32  ? 41  VAL B CG2  1 
ATOM   2177 N N    . ALA B 1 55  ? -29.696 -30.021 -36.314 1.00 33.99  ? 42  ALA B N    1 
ATOM   2178 C CA   . ALA B 1 55  ? -30.366 -30.395 -37.556 1.00 31.94  ? 42  ALA B CA   1 
ATOM   2179 C C    . ALA B 1 55  ? -29.475 -31.361 -38.331 1.00 37.30  ? 42  ALA B C    1 
ATOM   2180 O O    . ALA B 1 55  ? -28.262 -31.209 -38.313 1.00 43.22  ? 42  ALA B O    1 
ATOM   2181 C CB   . ALA B 1 55  ? -30.671 -29.167 -38.367 1.00 28.30  ? 42  ALA B CB   1 
ATOM   2182 N N    . PHE B 1 56  ? -30.070 -32.364 -38.976 1.00 36.11  ? 43  PHE B N    1 
ATOM   2183 C CA   . PHE B 1 56  ? -29.329 -33.178 -39.914 1.00 40.09  ? 43  PHE B CA   1 
ATOM   2184 C C    . PHE B 1 56  ? -30.116 -33.433 -41.201 1.00 44.69  ? 43  PHE B C    1 
ATOM   2185 O O    . PHE B 1 56  ? -31.354 -33.489 -41.201 1.00 46.84  ? 43  PHE B O    1 
ATOM   2186 C CB   . PHE B 1 56  ? -28.773 -34.422 -39.231 1.00 38.38  ? 43  PHE B CB   1 
ATOM   2187 C CG   . PHE B 1 56  ? -29.843 -35.367 -38.709 1.00 44.13  ? 43  PHE B CG   1 
ATOM   2188 C CD1  . PHE B 1 56  ? -30.622 -35.016 -37.606 1.00 41.17  ? 43  PHE B CD1  1 
ATOM   2189 C CD2  . PHE B 1 56  ? -30.022 -36.624 -39.284 1.00 43.04  ? 43  PHE B CD2  1 
ATOM   2190 C CE1  . PHE B 1 56  ? -31.587 -35.879 -37.108 1.00 36.96  ? 43  PHE B CE1  1 
ATOM   2191 C CE2  . PHE B 1 56  ? -30.984 -37.497 -38.774 1.00 35.88  ? 43  PHE B CE2  1 
ATOM   2192 C CZ   . PHE B 1 56  ? -31.769 -37.116 -37.695 1.00 38.52  ? 43  PHE B CZ   1 
ATOM   2193 N N    . LEU B 1 57  ? -29.339 -33.604 -42.288 1.00 48.39  ? 44  LEU B N    1 
ATOM   2194 C CA   . LEU B 1 57  ? -29.789 -33.843 -43.655 1.00 42.30  ? 44  LEU B CA   1 
ATOM   2195 C C    . LEU B 1 57  ? -29.429 -35.285 -43.998 1.00 44.24  ? 44  LEU B C    1 
ATOM   2196 O O    . LEU B 1 57  ? -28.374 -35.783 -43.601 1.00 39.45  ? 44  LEU B O    1 
ATOM   2197 C CB   . LEU B 1 57  ? -29.010 -32.876 -44.542 1.00 44.69  ? 44  LEU B CB   1 
ATOM   2198 C CG   . LEU B 1 57  ? -29.527 -31.439 -44.707 1.00 48.41  ? 44  LEU B CG   1 
ATOM   2199 C CD1  . LEU B 1 57  ? -30.159 -30.750 -43.537 1.00 41.66  ? 44  LEU B CD1  1 
ATOM   2200 C CD2  . LEU B 1 57  ? -28.372 -30.597 -45.225 1.00 53.97  ? 44  LEU B CD2  1 
ATOM   2201 N N    . ASP B 1 58  ? -30.322 -35.973 -44.701 1.00 43.58  ? 45  ASP B N    1 
ATOM   2202 C CA   . ASP B 1 58  ? -29.973 -37.286 -45.218 1.00 50.25  ? 45  ASP B CA   1 
ATOM   2203 C C    . ASP B 1 58  ? -30.970 -37.677 -46.308 1.00 52.48  ? 45  ASP B C    1 
ATOM   2204 O O    . ASP B 1 58  ? -32.098 -37.185 -46.339 1.00 42.54  ? 45  ASP B O    1 
ATOM   2205 C CB   . ASP B 1 58  ? -29.845 -38.337 -44.132 1.00 40.80  ? 45  ASP B CB   1 
ATOM   2206 C CG   . ASP B 1 58  ? -28.938 -39.515 -44.476 1.00 47.89  ? 45  ASP B CG   1 
ATOM   2207 O OD1  . ASP B 1 58  ? -29.360 -40.388 -45.294 1.00 43.41  ? 45  ASP B OD1  1 
ATOM   2208 O OD2  . ASP B 1 58  ? -27.810 -39.564 -43.913 1.00 41.66  ? 45  ASP B OD2  1 
ATOM   2209 N N    . LEU B 1 59  ? -30.509 -38.535 -47.221 1.00 50.49  ? 46  LEU B N    1 
ATOM   2210 C CA   . LEU B 1 59  ? -31.367 -39.009 -48.289 1.00 55.93  ? 46  LEU B CA   1 
ATOM   2211 C C    . LEU B 1 59  ? -32.314 -40.088 -47.747 1.00 50.63  ? 46  LEU B C    1 
ATOM   2212 O O    . LEU B 1 59  ? -33.447 -40.218 -48.193 1.00 51.67  ? 46  LEU B O    1 
ATOM   2213 C CB   . LEU B 1 59  ? -30.499 -39.495 -49.449 1.00 55.99  ? 46  LEU B CB   1 
ATOM   2214 C CG   . LEU B 1 59  ? -31.107 -39.307 -50.844 1.00 61.31  ? 46  LEU B CG   1 
ATOM   2215 C CD1  . LEU B 1 59  ? -30.066 -39.455 -51.949 1.00 63.19  ? 46  LEU B CD1  1 
ATOM   2216 C CD2  . LEU B 1 59  ? -32.226 -40.312 -51.044 1.00 68.05  ? 46  LEU B CD2  1 
ATOM   2217 N N    . ASP B 1 60  ? -31.866 -40.834 -46.735 1.00 52.38  ? 47  ASP B N    1 
ATOM   2218 C CA   . ASP B 1 60  ? -32.638 -41.949 -46.204 1.00 52.92  ? 47  ASP B CA   1 
ATOM   2219 C C    . ASP B 1 60  ? -33.638 -41.458 -45.151 1.00 50.22  ? 47  ASP B C    1 
ATOM   2220 O O    . ASP B 1 60  ? -33.278 -41.280 -43.999 1.00 41.87  ? 47  ASP B O    1 
ATOM   2221 C CB   . ASP B 1 60  ? -31.708 -43.053 -45.719 1.00 48.63  ? 47  ASP B CB   1 
ATOM   2222 C CG   . ASP B 1 60  ? -32.374 -44.280 -45.126 1.00 46.32  ? 47  ASP B CG   1 
ATOM   2223 O OD1  . ASP B 1 60  ? -33.601 -44.280 -45.009 1.00 48.42  ? 47  ASP B OD1  1 
ATOM   2224 O OD2  . ASP B 1 60  ? -31.647 -45.215 -44.778 1.00 55.75  ? 47  ASP B OD2  1 
ATOM   2225 N N    . ALA B 1 61  ? -34.900 -41.293 -45.566 1.00 48.65  ? 48  ALA B N    1 
ATOM   2226 C CA   . ALA B 1 61  ? -35.969 -40.718 -44.760 1.00 52.18  ? 48  ALA B CA   1 
ATOM   2227 C C    . ALA B 1 61  ? -36.321 -41.574 -43.536 1.00 51.14  ? 48  ALA B C    1 
ATOM   2228 O O    . ALA B 1 61  ? -36.542 -41.032 -42.462 1.00 48.11  ? 48  ALA B O    1 
ATOM   2229 C CB   . ALA B 1 61  ? -37.178 -40.437 -45.627 1.00 55.34  ? 48  ALA B CB   1 
ATOM   2230 N N    . GLU B 1 62  ? -36.355 -42.904 -43.687 1.00 53.63  ? 49  GLU B N    1 
ATOM   2231 C CA   . GLU B 1 62  ? -36.730 -43.786 -42.581 1.00 53.43  ? 49  GLU B CA   1 
ATOM   2232 C C    . GLU B 1 62  ? -35.598 -43.859 -41.549 1.00 49.54  ? 49  GLU B C    1 
ATOM   2233 O O    . GLU B 1 62  ? -35.833 -43.827 -40.343 1.00 41.48  ? 49  GLU B O    1 
ATOM   2234 C CB   . GLU B 1 62  ? -37.170 -45.174 -43.056 1.00 67.02  ? 49  GLU B CB   1 
ATOM   2235 N N    . ALA B 1 63  ? -34.346 -43.936 -42.012 1.00 49.85  ? 50  ALA B N    1 
ATOM   2236 C CA   . ALA B 1 63  ? -33.244 -43.870 -41.058 1.00 49.52  ? 50  ALA B CA   1 
ATOM   2237 C C    . ALA B 1 63  ? -33.235 -42.493 -40.384 1.00 50.09  ? 50  ALA B C    1 
ATOM   2238 O O    . ALA B 1 63  ? -33.040 -42.391 -39.177 1.00 46.36  ? 50  ALA B O    1 
ATOM   2239 C CB   . ALA B 1 63  ? -31.929 -44.234 -41.701 1.00 45.04  ? 50  ALA B CB   1 
ATOM   2240 N N    . GLY B 1 64  ? -33.509 -41.435 -41.154 1.00 43.14  ? 51  GLY B N    1 
ATOM   2241 C CA   . GLY B 1 64  ? -33.489 -40.081 -40.626 1.00 47.71  ? 51  GLY B CA   1 
ATOM   2242 C C    . GLY B 1 64  ? -34.488 -39.911 -39.491 1.00 47.14  ? 51  GLY B C    1 
ATOM   2243 O O    . GLY B 1 64  ? -34.131 -39.440 -38.418 1.00 35.33  ? 51  GLY B O    1 
ATOM   2244 N N    . GLN B 1 65  ? -35.733 -40.330 -39.751 1.00 49.52  ? 52  GLN B N    1 
ATOM   2245 C CA   . GLN B 1 65  ? -36.841 -40.152 -38.827 1.00 49.61  ? 52  GLN B CA   1 
ATOM   2246 C C    . GLN B 1 65  ? -36.654 -41.038 -37.596 1.00 47.99  ? 52  GLN B C    1 
ATOM   2247 O O    . GLN B 1 65  ? -36.985 -40.630 -36.501 1.00 47.31  ? 52  GLN B O    1 
ATOM   2248 C CB   . GLN B 1 65  ? -38.189 -40.473 -39.476 1.00 59.71  ? 52  GLN B CB   1 
ATOM   2249 C CG   . GLN B 1 65  ? -38.585 -39.503 -40.584 1.00 65.30  ? 52  GLN B CG   1 
ATOM   2250 C CD   . GLN B 1 65  ? -39.555 -40.104 -41.576 1.00 73.01  ? 52  GLN B CD   1 
ATOM   2251 O OE1  . GLN B 1 65  ? -40.180 -41.140 -41.315 1.00 74.54  ? 52  GLN B OE1  1 
ATOM   2252 N NE2  . GLN B 1 65  ? -39.701 -39.451 -42.722 1.00 66.62  ? 52  GLN B NE2  1 
ATOM   2253 N N    . GLY B 1 66  ? -36.117 -42.249 -37.757 1.00 51.37  ? 53  GLY B N    1 
ATOM   2254 C CA   . GLY B 1 66  ? -35.839 -43.098 -36.608 1.00 49.56  ? 53  GLY B CA   1 
ATOM   2255 C C    . GLY B 1 66  ? -34.800 -42.476 -35.663 1.00 51.86  ? 53  GLY B C    1 
ATOM   2256 O O    . GLY B 1 66  ? -34.868 -42.594 -34.436 1.00 49.93  ? 53  GLY B O    1 
ATOM   2257 N N    . LEU B 1 67  ? -33.803 -41.819 -36.249 1.00 48.21  ? 54  LEU B N    1 
ATOM   2258 C CA   . LEU B 1 67  ? -32.754 -41.240 -35.433 1.00 37.65  ? 54  LEU B CA   1 
ATOM   2259 C C    . LEU B 1 67  ? -33.318 -40.026 -34.700 1.00 31.76  ? 54  LEU B C    1 
ATOM   2260 O O    . LEU B 1 67  ? -33.093 -39.871 -33.509 1.00 34.84  ? 54  LEU B O    1 
ATOM   2261 C CB   . LEU B 1 67  ? -31.484 -40.950 -36.249 1.00 40.74  ? 54  LEU B CB   1 
ATOM   2262 N N    . ALA B 1 68  ? -34.087 -39.189 -35.402 1.00 38.35  ? 55  ALA B N    1 
ATOM   2263 C CA   . ALA B 1 68  ? -34.707 -38.017 -34.786 1.00 42.32  ? 55  ALA B CA   1 
ATOM   2264 C C    . ALA B 1 68  ? -35.690 -38.421 -33.682 1.00 48.84  ? 55  ALA B C    1 
ATOM   2265 O O    . ALA B 1 68  ? -35.815 -37.747 -32.656 1.00 52.99  ? 55  ALA B O    1 
ATOM   2266 C CB   . ALA B 1 68  ? -35.401 -37.186 -35.832 1.00 35.88  ? 55  ALA B CB   1 
ATOM   2267 N N    . HIS B 1 69  ? -36.399 -39.531 -33.912 1.00 48.17  ? 56  HIS B N    1 
ATOM   2268 C CA   . HIS B 1 69  ? -37.291 -40.082 -32.907 1.00 52.64  ? 56  HIS B CA   1 
ATOM   2269 C C    . HIS B 1 69  ? -36.476 -40.502 -31.688 1.00 47.35  ? 56  HIS B C    1 
ATOM   2270 O O    . HIS B 1 69  ? -36.854 -40.190 -30.571 1.00 49.18  ? 56  HIS B O    1 
ATOM   2271 C CB   . HIS B 1 69  ? -38.184 -41.191 -33.492 1.00 56.02  ? 56  HIS B CB   1 
ATOM   2272 C CG   . HIS B 1 69  ? -39.069 -41.829 -32.475 1.00 62.56  ? 56  HIS B CG   1 
ATOM   2273 N ND1  . HIS B 1 69  ? -38.758 -43.007 -31.820 1.00 57.78  ? 56  HIS B ND1  1 
ATOM   2274 C CD2  . HIS B 1 69  ? -40.242 -41.416 -31.984 1.00 59.63  ? 56  HIS B CD2  1 
ATOM   2275 C CE1  . HIS B 1 69  ? -39.725 -43.295 -30.960 1.00 66.27  ? 56  HIS B CE1  1 
ATOM   2276 N NE2  . HIS B 1 69  ? -40.640 -42.343 -31.047 1.00 69.53  ? 56  HIS B NE2  1 
ATOM   2277 N N    . ALA B 1 70  ? -35.357 -41.209 -31.891 1.00 47.90  ? 57  ALA B N    1 
ATOM   2278 C CA   . ALA B 1 70  ? -34.545 -41.622 -30.752 1.00 47.17  ? 57  ALA B CA   1 
ATOM   2279 C C    . ALA B 1 70  ? -33.978 -40.425 -29.965 1.00 46.63  ? 57  ALA B C    1 
ATOM   2280 O O    . ALA B 1 70  ? -33.833 -40.520 -28.749 1.00 48.09  ? 57  ALA B O    1 
ATOM   2281 C CB   . ALA B 1 70  ? -33.473 -42.619 -31.165 1.00 48.79  ? 57  ALA B CB   1 
ATOM   2282 N N    . LEU B 1 71  ? -33.687 -39.290 -30.629 1.00 46.83  ? 58  LEU B N    1 
ATOM   2283 C CA   . LEU B 1 71  ? -32.933 -38.199 -30.003 1.00 45.73  ? 58  LEU B CA   1 
ATOM   2284 C C    . LEU B 1 71  ? -33.867 -37.138 -29.422 1.00 45.62  ? 58  LEU B C    1 
ATOM   2285 O O    . LEU B 1 71  ? -33.468 -36.385 -28.539 1.00 44.03  ? 58  LEU B O    1 
ATOM   2286 C CB   . LEU B 1 71  ? -31.871 -37.564 -30.908 1.00 41.52  ? 58  LEU B CB   1 
ATOM   2287 N N    . GLY B 1 72  ? -35.091 -37.041 -29.953 1.00 45.20  ? 59  GLY B N    1 
ATOM   2288 C CA   . GLY B 1 72  ? -36.031 -36.118 -29.352 1.00 42.05  ? 59  GLY B CA   1 
ATOM   2289 C C    . GLY B 1 72  ? -35.963 -34.740 -29.994 1.00 39.80  ? 59  GLY B C    1 
ATOM   2290 O O    . GLY B 1 72  ? -35.461 -34.594 -31.106 1.00 46.76  ? 59  GLY B O    1 
ATOM   2291 N N    . ALA B 1 73  ? -36.532 -33.743 -29.300 1.00 35.68  ? 60  ALA B N    1 
ATOM   2292 C CA   . ALA B 1 73  ? -36.980 -32.529 -29.968 1.00 41.94  ? 60  ALA B CA   1 
ATOM   2293 C C    . ALA B 1 73  ? -35.846 -31.513 -30.145 1.00 42.34  ? 60  ALA B C    1 
ATOM   2294 O O    . ALA B 1 73  ? -36.041 -30.459 -30.743 1.00 53.02  ? 60  ALA B O    1 
ATOM   2295 C CB   . ALA B 1 73  ? -38.169 -31.930 -29.236 1.00 46.92  ? 60  ALA B CB   1 
ATOM   2296 N N    . ASN B 1 74  ? -34.659 -31.818 -29.613 1.00 47.16  ? 61  ASN B N    1 
ATOM   2297 C CA   . ASN B 1 74  ? -33.469 -31.025 -29.913 1.00 49.02  ? 61  ASN B CA   1 
ATOM   2298 C C    . ASN B 1 74  ? -32.742 -31.563 -31.154 1.00 51.68  ? 61  ASN B C    1 
ATOM   2299 O O    . ASN B 1 74  ? -31.634 -31.104 -31.468 1.00 52.03  ? 61  ASN B O    1 
ATOM   2300 C CB   . ASN B 1 74  ? -32.523 -30.932 -28.713 1.00 47.81  ? 61  ASN B CB   1 
ATOM   2301 C CG   . ASN B 1 74  ? -33.004 -29.944 -27.672 1.00 54.34  ? 61  ASN B CG   1 
ATOM   2302 O OD1  . ASN B 1 74  ? -33.864 -29.101 -27.980 1.00 48.78  ? 61  ASN B OD1  1 
ATOM   2303 N ND2  . ASN B 1 74  ? -32.445 -30.007 -26.464 1.00 45.63  ? 61  ASN B ND2  1 
ATOM   2304 N N    . SER B 1 75  ? -33.342 -32.573 -31.806 1.00 45.63  ? 62  SER B N    1 
ATOM   2305 C CA   . SER B 1 75  ? -32.906 -33.077 -33.096 1.00 50.88  ? 62  SER B CA   1 
ATOM   2306 C C    . SER B 1 75  ? -33.963 -32.722 -34.136 1.00 51.74  ? 62  SER B C    1 
ATOM   2307 O O    . SER B 1 75  ? -35.149 -32.689 -33.827 1.00 53.02  ? 62  SER B O    1 
ATOM   2308 C CB   . SER B 1 75  ? -32.587 -34.586 -33.062 1.00 51.06  ? 62  SER B CB   1 
ATOM   2309 O OG   . SER B 1 75  ? -33.731 -35.447 -33.109 1.00 39.38  ? 62  SER B OG   1 
ATOM   2310 N N    . LEU B 1 76  ? -33.504 -32.369 -35.337 1.00 48.14  ? 63  LEU B N    1 
ATOM   2311 C CA   . LEU B 1 76  ? -34.391 -32.047 -36.438 1.00 46.14  ? 63  LEU B CA   1 
ATOM   2312 C C    . LEU B 1 76  ? -33.881 -32.744 -37.691 1.00 47.59  ? 63  LEU B C    1 
ATOM   2313 O O    . LEU B 1 76  ? -32.765 -32.467 -38.126 1.00 42.78  ? 63  LEU B O    1 
ATOM   2314 C CB   . LEU B 1 76  ? -34.411 -30.534 -36.619 1.00 47.29  ? 63  LEU B CB   1 
ATOM   2315 C CG   . LEU B 1 76  ? -35.200 -30.014 -37.817 1.00 47.67  ? 63  LEU B CG   1 
ATOM   2316 C CD1  . LEU B 1 76  ? -36.652 -30.537 -37.762 1.00 48.71  ? 63  LEU B CD1  1 
ATOM   2317 C CD2  . LEU B 1 76  ? -35.152 -28.492 -37.665 1.00 44.12  ? 63  LEU B CD2  1 
ATOM   2318 N N    . PHE B 1 77  ? -34.699 -33.659 -38.237 1.00 40.68  ? 64  PHE B N    1 
ATOM   2319 C CA   . PHE B 1 77  ? -34.329 -34.387 -39.442 1.00 46.14  ? 64  PHE B CA   1 
ATOM   2320 C C    . PHE B 1 77  ? -34.985 -33.729 -40.649 1.00 45.33  ? 64  PHE B C    1 
ATOM   2321 O O    . PHE B 1 77  ? -36.195 -33.579 -40.673 1.00 46.84  ? 64  PHE B O    1 
ATOM   2322 C CB   . PHE B 1 77  ? -34.687 -35.879 -39.419 1.00 42.88  ? 64  PHE B CB   1 
ATOM   2323 C CG   . PHE B 1 77  ? -34.552 -36.529 -40.792 1.00 47.03  ? 64  PHE B CG   1 
ATOM   2324 C CD1  . PHE B 1 77  ? -33.323 -36.566 -41.447 1.00 40.08  ? 64  PHE B CD1  1 
ATOM   2325 C CD2  . PHE B 1 77  ? -35.654 -37.100 -41.436 1.00 43.45  ? 64  PHE B CD2  1 
ATOM   2326 C CE1  . PHE B 1 77  ? -33.189 -37.165 -42.705 1.00 45.71  ? 64  PHE B CE1  1 
ATOM   2327 C CE2  . PHE B 1 77  ? -35.524 -37.675 -42.699 1.00 47.57  ? 64  PHE B CE2  1 
ATOM   2328 C CZ   . PHE B 1 77  ? -34.290 -37.716 -43.338 1.00 41.42  ? 64  PHE B CZ   1 
ATOM   2329 N N    . LEU B 1 78  ? -34.175 -33.335 -41.639 1.00 52.91  ? 65  LEU B N    1 
ATOM   2330 C CA   . LEU B 1 78  ? -34.678 -32.786 -42.887 1.00 53.94  ? 65  LEU B CA   1 
ATOM   2331 C C    . LEU B 1 78  ? -34.254 -33.738 -43.993 1.00 61.32  ? 65  LEU B C    1 
ATOM   2332 O O    . LEU B 1 78  ? -33.061 -33.963 -44.206 1.00 62.09  ? 65  LEU B O    1 
ATOM   2333 C CB   . LEU B 1 78  ? -34.241 -31.354 -43.201 1.00 48.01  ? 65  LEU B CB   1 
ATOM   2334 C CG   . LEU B 1 78  ? -34.570 -30.298 -42.143 1.00 49.28  ? 65  LEU B CG   1 
ATOM   2335 C CD1  . LEU B 1 78  ? -34.303 -28.905 -42.716 1.00 47.71  ? 65  LEU B CD1  1 
ATOM   2336 C CD2  . LEU B 1 78  ? -36.018 -30.439 -41.702 1.00 61.41  ? 65  LEU B CD2  1 
ATOM   2337 N N    . PRO B 1 79  ? -35.216 -34.314 -44.742 1.00 63.91  ? 66  PRO B N    1 
ATOM   2338 C CA   . PRO B 1 79  ? -34.873 -35.071 -45.936 1.00 64.71  ? 66  PRO B CA   1 
ATOM   2339 C C    . PRO B 1 79  ? -34.200 -34.172 -46.975 1.00 55.29  ? 66  PRO B C    1 
ATOM   2340 O O    . PRO B 1 79  ? -34.606 -33.017 -47.164 1.00 49.14  ? 66  PRO B O    1 
ATOM   2341 C CB   . PRO B 1 79  ? -36.219 -35.681 -46.332 1.00 65.94  ? 66  PRO B CB   1 
ATOM   2342 C CG   . PRO B 1 79  ? -37.197 -34.599 -45.873 1.00 66.41  ? 66  PRO B CG   1 
ATOM   2343 C CD   . PRO B 1 79  ? -36.666 -34.194 -44.531 1.00 63.95  ? 66  PRO B CD   1 
ATOM   2344 N N    . CYS B 1 80  ? -33.133 -34.678 -47.601 1.00 47.76  ? 67  CYS B N    1 
ATOM   2345 C CA   . CYS B 1 80  ? -32.370 -33.848 -48.526 1.00 50.95  ? 67  CYS B CA   1 
ATOM   2346 C C    . CYS B 1 80  ? -31.440 -34.724 -49.346 1.00 51.12  ? 67  CYS B C    1 
ATOM   2347 O O    . CYS B 1 80  ? -30.712 -35.555 -48.808 1.00 56.37  ? 67  CYS B O    1 
ATOM   2348 C CB   . CYS B 1 80  ? -31.554 -32.778 -47.809 1.00 52.46  ? 67  CYS B CB   1 
ATOM   2349 S SG   . CYS B 1 80  ? -30.813 -31.571 -48.942 1.00 53.08  ? 67  CYS B SG   1 
ATOM   2350 N N    . ASP B 1 81  ? -31.543 -34.573 -50.664 1.00 55.51  ? 68  ASP B N    1 
ATOM   2351 C CA   . ASP B 1 81  ? -30.542 -35.094 -51.576 1.00 56.69  ? 68  ASP B CA   1 
ATOM   2352 C C    . ASP B 1 81  ? -29.574 -33.946 -51.863 1.00 51.58  ? 68  ASP B C    1 
ATOM   2353 O O    . ASP B 1 81  ? -29.964 -32.960 -52.488 1.00 51.70  ? 68  ASP B O    1 
ATOM   2354 C CB   . ASP B 1 81  ? -31.196 -35.717 -52.802 1.00 60.54  ? 68  ASP B CB   1 
ATOM   2355 C CG   . ASP B 1 81  ? -30.262 -36.129 -53.929 1.00 60.97  ? 68  ASP B CG   1 
ATOM   2356 O OD1  . ASP B 1 81  ? -29.030 -35.952 -53.774 1.00 60.17  ? 68  ASP B OD1  1 
ATOM   2357 O OD2  . ASP B 1 81  ? -30.788 -36.603 -54.956 1.00 63.54  ? 68  ASP B OD2  1 
ATOM   2358 N N    . VAL B 1 82  ? -28.328 -34.087 -51.378 1.00 44.62  ? 69  VAL B N    1 
ATOM   2359 C CA   . VAL B 1 82  ? -27.366 -32.984 -51.371 1.00 45.12  ? 69  VAL B CA   1 
ATOM   2360 C C    . VAL B 1 82  ? -26.969 -32.599 -52.799 1.00 42.88  ? 69  VAL B C    1 
ATOM   2361 O O    . VAL B 1 82  ? -26.520 -31.470 -53.016 1.00 43.95  ? 69  VAL B O    1 
ATOM   2362 C CB   . VAL B 1 82  ? -26.128 -33.167 -50.458 1.00 37.03  ? 69  VAL B CB   1 
ATOM   2363 C CG1  . VAL B 1 82  ? -26.517 -33.054 -48.991 1.00 46.48  ? 69  VAL B CG1  1 
ATOM   2364 C CG2  . VAL B 1 82  ? -25.416 -34.488 -50.702 1.00 32.37  ? 69  VAL B CG2  1 
ATOM   2365 N N    . ARG B 1 83  ? -27.103 -33.555 -53.737 1.00 39.35  ? 70  ARG B N    1 
ATOM   2366 C CA   . ARG B 1 83  ? -27.012 -33.289 -55.173 1.00 44.05  ? 70  ARG B CA   1 
ATOM   2367 C C    . ARG B 1 83  ? -27.911 -32.116 -55.539 1.00 37.29  ? 70  ARG B C    1 
ATOM   2368 O O    . ARG B 1 83  ? -27.556 -31.331 -56.423 1.00 42.24  ? 70  ARG B O    1 
ATOM   2369 C CB   . ARG B 1 83  ? -27.342 -34.447 -56.124 1.00 34.53  ? 70  ARG B CB   1 
ATOM   2370 C CG   . ARG B 1 83  ? -26.419 -35.641 -55.965 1.00 44.24  ? 70  ARG B CG   1 
ATOM   2371 C CD   . ARG B 1 83  ? -27.103 -36.884 -56.532 1.00 51.06  ? 70  ARG B CD   1 
ATOM   2372 N N    . ASP B 1 84  ? -29.081 -32.026 -54.887 1.00 43.13  ? 71  ASP B N    1 
ATOM   2373 C CA   . ASP B 1 84  ? -30.038 -30.962 -55.182 1.00 52.36  ? 71  ASP B CA   1 
ATOM   2374 C C    . ASP B 1 84  ? -29.718 -29.743 -54.336 1.00 47.35  ? 71  ASP B C    1 
ATOM   2375 O O    . ASP B 1 84  ? -30.138 -29.666 -53.187 1.00 55.82  ? 71  ASP B O    1 
ATOM   2376 C CB   . ASP B 1 84  ? -31.495 -31.397 -55.032 1.00 67.69  ? 71  ASP B CB   1 
ATOM   2377 C CG   . ASP B 1 84  ? -32.594 -30.346 -55.239 1.00 69.38  ? 71  ASP B CG   1 
ATOM   2378 O OD1  . ASP B 1 84  ? -32.292 -29.139 -55.314 1.00 57.22  ? 71  ASP B OD1  1 
ATOM   2379 O OD2  . ASP B 1 84  ? -33.784 -30.735 -55.322 1.00 71.78  ? 71  ASP B OD2  1 
ATOM   2380 N N    . ILE B 1 85  ? -29.010 -28.787 -54.935 1.00 50.82  ? 72  ILE B N    1 
ATOM   2381 C CA   . ILE B 1 85  ? -28.573 -27.598 -54.224 1.00 52.81  ? 72  ILE B CA   1 
ATOM   2382 C C    . ILE B 1 85  ? -29.767 -26.744 -53.806 1.00 52.51  ? 72  ILE B C    1 
ATOM   2383 O O    . ILE B 1 85  ? -29.694 -26.036 -52.802 1.00 59.59  ? 72  ILE B O    1 
ATOM   2384 C CB   . ILE B 1 85  ? -27.546 -26.786 -55.035 1.00 48.22  ? 72  ILE B CB   1 
ATOM   2385 C CG1  . ILE B 1 85  ? -26.275 -27.587 -55.324 1.00 47.46  ? 72  ILE B CG1  1 
ATOM   2386 C CG2  . ILE B 1 85  ? -27.259 -25.433 -54.370 1.00 42.76  ? 72  ILE B CG2  1 
ATOM   2387 C CD1  . ILE B 1 85  ? -25.578 -28.151 -54.098 1.00 45.02  ? 72  ILE B CD1  1 
ATOM   2388 N N    . GLU B 1 86  ? -30.846 -26.776 -54.591 1.00 56.83  ? 73  GLU B N    1 
ATOM   2389 C CA   . GLU B 1 86  ? -32.018 -25.948 -54.307 1.00 49.11  ? 73  GLU B CA   1 
ATOM   2390 C C    . GLU B 1 86  ? -32.663 -26.395 -52.994 1.00 39.92  ? 73  GLU B C    1 
ATOM   2391 O O    . GLU B 1 86  ? -32.944 -25.575 -52.130 1.00 41.81  ? 73  GLU B O    1 
ATOM   2392 C CB   . GLU B 1 86  ? -32.986 -25.966 -55.493 1.00 50.55  ? 73  GLU B CB   1 
ATOM   2393 N N    . ARG B 1 87  ? -32.806 -27.716 -52.829 1.00 36.74  ? 74  ARG B N    1 
ATOM   2394 C CA   . ARG B 1 87  ? -33.298 -28.334 -51.607 1.00 41.17  ? 74  ARG B CA   1 
ATOM   2395 C C    . ARG B 1 87  ? -32.311 -28.092 -50.457 1.00 48.91  ? 74  ARG B C    1 
ATOM   2396 O O    . ARG B 1 87  ? -32.719 -27.734 -49.353 1.00 45.73  ? 74  ARG B O    1 
ATOM   2397 C CB   . ARG B 1 87  ? -33.535 -29.818 -51.901 1.00 42.66  ? 74  ARG B CB   1 
ATOM   2398 C CG   . ARG B 1 87  ? -33.901 -30.704 -50.718 1.00 52.11  ? 74  ARG B CG   1 
ATOM   2399 C CD   . ARG B 1 87  ? -35.327 -30.425 -50.250 1.00 57.80  ? 74  ARG B CD   1 
ATOM   2400 N NE   . ARG B 1 87  ? -35.655 -31.044 -48.961 1.00 59.38  ? 74  ARG B NE   1 
ATOM   2401 C CZ   . ARG B 1 87  ? -36.265 -30.417 -47.959 1.00 65.23  ? 74  ARG B CZ   1 
ATOM   2402 N NH1  . ARG B 1 87  ? -36.700 -29.173 -48.127 1.00 62.45  ? 74  ARG B NH1  1 
ATOM   2403 N NH2  . ARG B 1 87  ? -36.451 -31.048 -46.803 1.00 63.45  ? 74  ARG B NH2  1 
ATOM   2404 N N    . LEU B 1 88  ? -31.007 -28.289 -50.708 1.00 47.73  ? 75  LEU B N    1 
ATOM   2405 C CA   . LEU B 1 88  ? -29.980 -27.955 -49.723 1.00 46.08  ? 75  LEU B CA   1 
ATOM   2406 C C    . LEU B 1 88  ? -30.163 -26.523 -49.219 1.00 40.91  ? 75  LEU B C    1 
ATOM   2407 O O    . LEU B 1 88  ? -30.158 -26.316 -48.019 1.00 46.87  ? 75  LEU B O    1 
ATOM   2408 C CB   . LEU B 1 88  ? -28.559 -28.159 -50.243 1.00 42.16  ? 75  LEU B CB   1 
ATOM   2409 C CG   . LEU B 1 88  ? -27.421 -27.709 -49.314 1.00 35.81  ? 75  LEU B CG   1 
ATOM   2410 C CD1  . LEU B 1 88  ? -27.320 -28.548 -48.080 1.00 38.83  ? 75  LEU B CD1  1 
ATOM   2411 C CD2  . LEU B 1 88  ? -26.148 -27.807 -50.087 1.00 37.33  ? 75  LEU B CD2  1 
ATOM   2412 N N    . LYS B 1 89  ? -30.314 -25.530 -50.099 1.00 41.51  ? 76  LYS B N    1 
ATOM   2413 C CA   . LYS B 1 89  ? -30.493 -24.171 -49.602 1.00 42.54  ? 76  LYS B CA   1 
ATOM   2414 C C    . LYS B 1 89  ? -31.850 -24.008 -48.901 1.00 47.12  ? 76  LYS B C    1 
ATOM   2415 O O    . LYS B 1 89  ? -31.972 -23.201 -47.987 1.00 52.02  ? 76  LYS B O    1 
ATOM   2416 C CB   . LYS B 1 89  ? -30.375 -23.090 -50.674 1.00 45.98  ? 76  LYS B CB   1 
ATOM   2417 C CG   . LYS B 1 89  ? -29.173 -23.136 -51.579 1.00 48.30  ? 76  LYS B CG   1 
ATOM   2418 N N    . ALA B 1 90  ? -32.866 -24.791 -49.289 1.00 43.61  ? 77  ALA B N    1 
ATOM   2419 C CA   . ALA B 1 90  ? -34.120 -24.698 -48.558 1.00 48.40  ? 77  ALA B CA   1 
ATOM   2420 C C    . ALA B 1 90  ? -33.973 -25.304 -47.162 1.00 48.17  ? 77  ALA B C    1 
ATOM   2421 O O    . ALA B 1 90  ? -34.530 -24.778 -46.203 1.00 45.58  ? 77  ALA B O    1 
ATOM   2422 C CB   . ALA B 1 90  ? -35.279 -25.312 -49.337 1.00 43.59  ? 77  ALA B CB   1 
ATOM   2423 N N    . CYS B 1 91  ? -33.231 -26.417 -47.054 1.00 40.66  ? 78  CYS B N    1 
ATOM   2424 C CA   . CYS B 1 91  ? -33.007 -27.051 -45.771 1.00 43.69  ? 78  CYS B CA   1 
ATOM   2425 C C    . CYS B 1 91  ? -32.340 -26.081 -44.806 1.00 46.04  ? 78  CYS B C    1 
ATOM   2426 O O    . CYS B 1 91  ? -32.727 -26.006 -43.647 1.00 50.91  ? 78  CYS B O    1 
ATOM   2427 C CB   . CYS B 1 91  ? -32.157 -28.300 -45.917 1.00 48.89  ? 78  CYS B CB   1 
ATOM   2428 S SG   . CYS B 1 91  ? -33.093 -29.676 -46.624 1.00 53.23  ? 78  CYS B SG   1 
ATOM   2429 N N    . VAL B 1 92  ? -31.352 -25.331 -45.301 1.00 47.80  ? 79  VAL B N    1 
ATOM   2430 C CA   . VAL B 1 92  ? -30.626 -24.347 -44.512 1.00 47.45  ? 79  VAL B CA   1 
ATOM   2431 C C    . VAL B 1 92  ? -31.604 -23.270 -44.050 1.00 49.62  ? 79  VAL B C    1 
ATOM   2432 O O    . VAL B 1 92  ? -31.646 -22.946 -42.868 1.00 43.37  ? 79  VAL B O    1 
ATOM   2433 C CB   . VAL B 1 92  ? -29.409 -23.756 -45.270 1.00 46.82  ? 79  VAL B CB   1 
ATOM   2434 C CG1  . VAL B 1 92  ? -28.850 -22.466 -44.658 1.00 37.23  ? 79  VAL B CG1  1 
ATOM   2435 C CG2  . VAL B 1 92  ? -28.313 -24.801 -45.480 1.00 33.18  ? 79  VAL B CG2  1 
ATOM   2436 N N    . ALA B 1 93  ? -32.375 -22.716 -44.990 1.00 52.53  ? 80  ALA B N    1 
ATOM   2437 C CA   . ALA B 1 93  ? -33.310 -21.622 -44.722 1.00 49.64  ? 80  ALA B CA   1 
ATOM   2438 C C    . ALA B 1 93  ? -34.280 -22.041 -43.612 1.00 54.47  ? 80  ALA B C    1 
ATOM   2439 O O    . ALA B 1 93  ? -34.626 -21.241 -42.744 1.00 52.56  ? 80  ALA B O    1 
ATOM   2440 C CB   . ALA B 1 93  ? -34.045 -21.257 -46.011 1.00 41.76  ? 80  ALA B CB   1 
ATOM   2441 N N    . GLU B 1 94  ? -34.676 -23.325 -43.637 1.00 51.51  ? 81  GLU B N    1 
ATOM   2442 C CA   . GLU B 1 94  ? -35.655 -23.882 -42.709 1.00 56.32  ? 81  GLU B CA   1 
ATOM   2443 C C    . GLU B 1 94  ? -35.032 -23.970 -41.322 1.00 60.51  ? 81  GLU B C    1 
ATOM   2444 O O    . GLU B 1 94  ? -35.670 -23.650 -40.319 1.00 54.62  ? 81  GLU B O    1 
ATOM   2445 C CB   . GLU B 1 94  ? -36.173 -25.273 -43.089 1.00 49.31  ? 81  GLU B CB   1 
ATOM   2446 N N    . VAL B 1 95  ? -33.770 -24.409 -41.278 1.00 55.00  ? 82  VAL B N    1 
ATOM   2447 C CA   . VAL B 1 95  ? -33.070 -24.461 -40.012 1.00 43.75  ? 82  VAL B CA   1 
ATOM   2448 C C    . VAL B 1 95  ? -32.982 -23.054 -39.421 1.00 37.07  ? 82  VAL B C    1 
ATOM   2449 O O    . VAL B 1 95  ? -33.288 -22.848 -38.248 1.00 47.18  ? 82  VAL B O    1 
ATOM   2450 C CB   . VAL B 1 95  ? -31.719 -25.189 -40.094 1.00 41.44  ? 82  VAL B CB   1 
ATOM   2451 C CG1  . VAL B 1 95  ? -30.987 -25.106 -38.765 1.00 41.81  ? 82  VAL B CG1  1 
ATOM   2452 C CG2  . VAL B 1 95  ? -31.894 -26.648 -40.502 1.00 37.90  ? 82  VAL B CG2  1 
ATOM   2453 N N    . GLU B 1 96  ? -32.601 -22.081 -40.239 1.00 38.31  ? 83  GLU B N    1 
ATOM   2454 C CA   . GLU B 1 96  ? -32.487 -20.698 -39.794 1.00 42.09  ? 83  GLU B CA   1 
ATOM   2455 C C    . GLU B 1 96  ? -33.789 -20.168 -39.217 1.00 51.99  ? 83  GLU B C    1 
ATOM   2456 O O    . GLU B 1 96  ? -33.750 -19.444 -38.229 1.00 62.38  ? 83  GLU B O    1 
ATOM   2457 C CB   . GLU B 1 96  ? -32.018 -19.797 -40.929 1.00 44.73  ? 83  GLU B CB   1 
ATOM   2458 C CG   . GLU B 1 96  ? -30.569 -20.091 -41.305 1.00 59.18  ? 83  GLU B CG   1 
ATOM   2459 C CD   . GLU B 1 96  ? -29.923 -19.136 -42.291 1.00 64.71  ? 83  GLU B CD   1 
ATOM   2460 O OE1  . GLU B 1 96  ? -30.546 -18.911 -43.368 1.00 63.34  ? 83  GLU B OE1  1 
ATOM   2461 O OE2  . GLU B 1 96  ? -28.798 -18.653 -41.975 1.00 52.98  ? 83  GLU B OE2  1 
ATOM   2462 N N    . ARG B 1 97  ? -34.922 -20.497 -39.865 1.00 56.31  ? 84  ARG B N    1 
ATOM   2463 C CA   . ARG B 1 97  ? -36.220 -19.988 -39.449 1.00 58.28  ? 84  ARG B CA   1 
ATOM   2464 C C    . ARG B 1 97  ? -36.610 -20.620 -38.112 1.00 51.25  ? 84  ARG B C    1 
ATOM   2465 O O    . ARG B 1 97  ? -37.088 -19.929 -37.223 1.00 49.15  ? 84  ARG B O    1 
ATOM   2466 C CB   . ARG B 1 97  ? -37.311 -20.167 -40.517 1.00 61.30  ? 84  ARG B CB   1 
ATOM   2467 N N    . THR B 1 98  ? -36.380 -21.929 -37.966 1.00 47.21  ? 85  THR B N    1 
ATOM   2468 C CA   . THR B 1 98  ? -36.704 -22.624 -36.733 1.00 46.84  ? 85  THR B CA   1 
ATOM   2469 C C    . THR B 1 98  ? -35.859 -22.094 -35.567 1.00 59.40  ? 85  THR B C    1 
ATOM   2470 O O    . THR B 1 98  ? -36.411 -21.650 -34.560 1.00 51.90  ? 85  THR B O    1 
ATOM   2471 C CB   . THR B 1 98  ? -36.524 -24.125 -36.962 1.00 56.42  ? 85  THR B CB   1 
ATOM   2472 O OG1  . THR B 1 98  ? -37.342 -24.364 -38.100 1.00 68.28  ? 85  THR B OG1  1 
ATOM   2473 C CG2  . THR B 1 98  ? -37.058 -24.996 -35.841 1.00 58.08  ? 85  THR B CG2  1 
ATOM   2474 N N    . TRP B 1 99  ? -34.522 -22.114 -35.710 1.00 59.53  ? 86  TRP B N    1 
ATOM   2475 C CA   . TRP B 1 99  ? -33.616 -22.014 -34.575 1.00 45.88  ? 86  TRP B CA   1 
ATOM   2476 C C    . TRP B 1 99  ? -32.718 -20.784 -34.656 1.00 46.76  ? 86  TRP B C    1 
ATOM   2477 O O    . TRP B 1 99  ? -31.992 -20.524 -33.709 1.00 56.76  ? 86  TRP B O    1 
ATOM   2478 C CB   . TRP B 1 99  ? -32.758 -23.281 -34.483 1.00 38.93  ? 86  TRP B CB   1 
ATOM   2479 C CG   . TRP B 1 99  ? -33.500 -24.464 -33.928 1.00 40.28  ? 86  TRP B CG   1 
ATOM   2480 C CD1  . TRP B 1 99  ? -34.628 -24.421 -33.167 1.00 38.10  ? 86  TRP B CD1  1 
ATOM   2481 C CD2  . TRP B 1 99  ? -33.171 -25.858 -34.080 1.00 33.98  ? 86  TRP B CD2  1 
ATOM   2482 N NE1  . TRP B 1 99  ? -35.005 -25.692 -32.823 1.00 43.31  ? 86  TRP B NE1  1 
ATOM   2483 C CE2  . TRP B 1 99  ? -34.137 -26.595 -33.370 1.00 41.54  ? 86  TRP B CE2  1 
ATOM   2484 C CE3  . TRP B 1 99  ? -32.161 -26.557 -34.737 1.00 39.31  ? 86  TRP B CE3  1 
ATOM   2485 C CZ2  . TRP B 1 99  ? -34.117 -27.994 -33.291 1.00 48.43  ? 86  TRP B CZ2  1 
ATOM   2486 C CZ3  . TRP B 1 99  ? -32.147 -27.942 -34.676 1.00 46.30  ? 86  TRP B CZ3  1 
ATOM   2487 C CH2  . TRP B 1 99  ? -33.102 -28.658 -33.949 1.00 40.44  ? 86  TRP B CH2  1 
ATOM   2488 N N    . GLY B 1 100 ? -32.722 -20.049 -35.777 1.00 53.87  ? 87  GLY B N    1 
ATOM   2489 C CA   . GLY B 1 100 ? -31.776 -18.949 -35.985 1.00 47.43  ? 87  GLY B CA   1 
ATOM   2490 C C    . GLY B 1 100 ? -30.534 -19.387 -36.780 1.00 46.40  ? 87  GLY B C    1 
ATOM   2491 O O    . GLY B 1 100 ? -30.465 -20.540 -37.232 1.00 47.62  ? 87  GLY B O    1 
ATOM   2492 N N    . ALA B 1 101 ? -29.575 -18.454 -36.974 1.00 47.83  ? 88  ALA B N    1 
ATOM   2493 C CA   . ALA B 1 101 ? -28.318 -18.693 -37.695 1.00 52.51  ? 88  ALA B CA   1 
ATOM   2494 C C    . ALA B 1 101 ? -27.631 -19.982 -37.223 1.00 47.14  ? 88  ALA B C    1 
ATOM   2495 O O    . ALA B 1 101 ? -27.563 -20.247 -36.024 1.00 42.29  ? 88  ALA B O    1 
ATOM   2496 C CB   . ALA B 1 101 ? -27.375 -17.511 -37.530 1.00 44.98  ? 88  ALA B CB   1 
ATOM   2497 N N    . VAL B 1 102 ? -27.122 -20.786 -38.167 1.00 43.26  ? 89  VAL B N    1 
ATOM   2498 C CA   . VAL B 1 102 ? -26.304 -21.935 -37.806 1.00 39.07  ? 89  VAL B CA   1 
ATOM   2499 C C    . VAL B 1 102 ? -25.046 -21.472 -37.061 1.00 40.05  ? 89  VAL B C    1 
ATOM   2500 O O    . VAL B 1 102 ? -24.409 -20.488 -37.438 1.00 35.81  ? 89  VAL B O    1 
ATOM   2501 C CB   . VAL B 1 102 ? -25.986 -22.790 -39.050 1.00 41.46  ? 89  VAL B CB   1 
ATOM   2502 C CG1  . VAL B 1 102 ? -25.156 -24.036 -38.729 1.00 37.83  ? 89  VAL B CG1  1 
ATOM   2503 C CG2  . VAL B 1 102 ? -27.276 -23.244 -39.726 1.00 34.83  ? 89  VAL B CG2  1 
ATOM   2504 N N    . ASP B 1 103 ? -24.724 -22.184 -35.967 1.00 39.26  ? 90  ASP B N    1 
ATOM   2505 C CA   . ASP B 1 103 ? -23.484 -21.977 -35.234 1.00 38.68  ? 90  ASP B CA   1 
ATOM   2506 C C    . ASP B 1 103 ? -22.394 -22.881 -35.810 1.00 35.18  ? 90  ASP B C    1 
ATOM   2507 O O    . ASP B 1 103 ? -21.288 -22.423 -36.001 1.00 35.00  ? 90  ASP B O    1 
ATOM   2508 C CB   . ASP B 1 103 ? -23.676 -22.161 -33.733 1.00 36.75  ? 90  ASP B CB   1 
ATOM   2509 C CG   . ASP B 1 103 ? -24.578 -21.139 -33.053 1.00 40.30  ? 90  ASP B CG   1 
ATOM   2510 O OD1  . ASP B 1 103 ? -24.147 -19.958 -33.006 1.00 40.08  ? 90  ASP B OD1  1 
ATOM   2511 O OD2  . ASP B 1 103 ? -25.705 -21.529 -32.597 1.00 40.60  ? 90  ASP B OD2  1 
ATOM   2512 N N    . VAL B 1 104 ? -22.710 -24.162 -36.044 1.00 34.30  ? 91  VAL B N    1 
ATOM   2513 C CA   . VAL B 1 104 ? -21.717 -25.140 -36.449 1.00 38.23  ? 91  VAL B CA   1 
ATOM   2514 C C    . VAL B 1 104 ? -22.251 -25.863 -37.684 1.00 34.92  ? 91  VAL B C    1 
ATOM   2515 O O    . VAL B 1 104 ? -23.321 -26.439 -37.614 1.00 31.99  ? 91  VAL B O    1 
ATOM   2516 C CB   . VAL B 1 104 ? -21.416 -26.169 -35.338 1.00 34.45  ? 91  VAL B CB   1 
ATOM   2517 C CG1  . VAL B 1 104 ? -20.479 -27.272 -35.815 1.00 31.86  ? 91  VAL B CG1  1 
ATOM   2518 C CG2  . VAL B 1 104 ? -20.940 -25.523 -34.045 1.00 33.88  ? 91  VAL B CG2  1 
ATOM   2519 N N    . LEU B 1 105 ? -21.474 -25.887 -38.783 1.00 33.25  ? 92  LEU B N    1 
ATOM   2520 C CA   . LEU B 1 105 ? -21.835 -26.678 -39.949 1.00 28.69  ? 92  LEU B CA   1 
ATOM   2521 C C    . LEU B 1 105 ? -20.827 -27.809 -40.094 1.00 32.26  ? 92  LEU B C    1 
ATOM   2522 O O    . LEU B 1 105 ? -19.632 -27.586 -40.071 1.00 33.40  ? 92  LEU B O    1 
ATOM   2523 C CB   . LEU B 1 105 ? -21.908 -25.807 -41.209 1.00 32.17  ? 92  LEU B CB   1 
ATOM   2524 C CG   . LEU B 1 105 ? -21.945 -26.538 -42.560 1.00 34.00  ? 92  LEU B CG   1 
ATOM   2525 C CD1  . LEU B 1 105 ? -23.218 -27.373 -42.829 1.00 35.22  ? 92  LEU B CD1  1 
ATOM   2526 C CD2  . LEU B 1 105 ? -21.737 -25.578 -43.724 1.00 35.01  ? 92  LEU B CD2  1 
ATOM   2527 N N    . ILE B 1 106 ? -21.311 -29.032 -40.246 1.00 32.15  ? 93  ILE B N    1 
ATOM   2528 C CA   . ILE B 1 106 ? -20.418 -30.127 -40.565 1.00 31.97  ? 93  ILE B CA   1 
ATOM   2529 C C    . ILE B 1 106 ? -20.789 -30.684 -41.943 1.00 34.88  ? 93  ILE B C    1 
ATOM   2530 O O    . ILE B 1 106 ? -21.838 -31.307 -42.131 1.00 30.26  ? 93  ILE B O    1 
ATOM   2531 C CB   . ILE B 1 106 ? -20.474 -31.187 -39.460 1.00 30.69  ? 93  ILE B CB   1 
ATOM   2532 C CG1  . ILE B 1 106 ? -20.294 -30.540 -38.085 1.00 35.04  ? 93  ILE B CG1  1 
ATOM   2533 C CG2  . ILE B 1 106 ? -19.471 -32.325 -39.734 1.00 28.95  ? 93  ILE B CG2  1 
ATOM   2534 C CD1  . ILE B 1 106 ? -20.069 -31.521 -36.940 1.00 29.98  ? 93  ILE B CD1  1 
ATOM   2535 N N    . ASN B 1 107 ? -19.931 -30.411 -42.928 1.00 32.58  ? 94  ASN B N    1 
ATOM   2536 C CA   . ASN B 1 107 ? -20.123 -30.944 -44.261 1.00 33.40  ? 94  ASN B CA   1 
ATOM   2537 C C    . ASN B 1 107 ? -19.600 -32.363 -44.259 1.00 33.10  ? 94  ASN B C    1 
ATOM   2538 O O    . ASN B 1 107 ? -18.399 -32.527 -44.304 1.00 30.49  ? 94  ASN B O    1 
ATOM   2539 C CB   . ASN B 1 107 ? -19.354 -30.114 -45.274 1.00 33.94  ? 94  ASN B CB   1 
ATOM   2540 C CG   . ASN B 1 107 ? -20.006 -28.771 -45.480 1.00 35.22  ? 94  ASN B CG   1 
ATOM   2541 O OD1  . ASN B 1 107 ? -21.241 -28.693 -45.572 1.00 30.23  ? 94  ASN B OD1  1 
ATOM   2542 N ND2  . ASN B 1 107 ? -19.195 -27.719 -45.537 1.00 28.36  ? 94  ASN B ND2  1 
ATOM   2543 N N    . ASN B 1 108 ? -20.507 -33.343 -44.131 1.00 33.72  ? 95  ASN B N    1 
ATOM   2544 C CA   . ASN B 1 108 ? -20.158 -34.735 -43.884 1.00 30.35  ? 95  ASN B CA   1 
ATOM   2545 C C    . ASN B 1 108 ? -20.601 -35.621 -45.060 1.00 30.34  ? 95  ASN B C    1 
ATOM   2546 O O    . ASN B 1 108 ? -20.023 -36.675 -45.313 1.00 33.29  ? 95  ASN B O    1 
ATOM   2547 C CB   . ASN B 1 108 ? -20.678 -35.188 -42.509 1.00 27.09  ? 95  ASN B CB   1 
ATOM   2548 C CG   . ASN B 1 108 ? -20.552 -36.688 -42.334 1.00 34.00  ? 95  ASN B CG   1 
ATOM   2549 O OD1  . ASN B 1 108 ? -19.447 -37.164 -42.081 1.00 33.00  ? 95  ASN B OD1  1 
ATOM   2550 N ND2  . ASN B 1 108 ? -21.639 -37.457 -42.471 1.00 31.12  ? 95  ASN B ND2  1 
ATOM   2551 N N    . ALA B 1 109 ? -21.635 -35.222 -45.797 1.00 33.64  ? 96  ALA B N    1 
ATOM   2552 C CA   . ALA B 1 109 ? -22.229 -36.155 -46.767 1.00 33.87  ? 96  ALA B CA   1 
ATOM   2553 C C    . ALA B 1 109 ? -21.251 -36.516 -47.878 1.00 36.40  ? 96  ALA B C    1 
ATOM   2554 O O    . ALA B 1 109 ? -20.623 -35.650 -48.465 1.00 34.76  ? 96  ALA B O    1 
ATOM   2555 C CB   . ALA B 1 109 ? -23.542 -35.631 -47.347 1.00 29.52  ? 96  ALA B CB   1 
ATOM   2556 N N    . ALA B 1 110 ? -21.168 -37.810 -48.196 1.00 34.56  ? 97  ALA B N    1 
ATOM   2557 C CA   . ALA B 1 110 ? -20.182 -38.265 -49.151 1.00 45.14  ? 97  ALA B CA   1 
ATOM   2558 C C    . ALA B 1 110 ? -20.553 -39.681 -49.574 1.00 51.30  ? 97  ALA B C    1 
ATOM   2559 O O    . ALA B 1 110 ? -21.235 -40.374 -48.812 1.00 45.57  ? 97  ALA B O    1 
ATOM   2560 C CB   . ALA B 1 110 ? -18.837 -38.275 -48.449 1.00 41.61  ? 97  ALA B CB   1 
ATOM   2561 N N    . ARG B 1 111 ? -20.021 -40.109 -50.733 1.00 45.11  ? 98  ARG B N    1 
ATOM   2562 C CA   . ARG B 1 111 ? -20.192 -41.457 -51.249 1.00 41.83  ? 98  ARG B CA   1 
ATOM   2563 C C    . ARG B 1 111 ? -18.823 -42.011 -51.636 1.00 42.83  ? 98  ARG B C    1 
ATOM   2564 O O    . ARG B 1 111 ? -18.145 -41.485 -52.521 1.00 38.26  ? 98  ARG B O    1 
ATOM   2565 C CB   . ARG B 1 111 ? -21.217 -41.470 -52.398 1.00 47.86  ? 98  ARG B CB   1 
ATOM   2566 N N    . ASP B 1 112 ? -18.419 -43.075 -50.948 1.00 40.29  ? 99  ASP B N    1 
ATOM   2567 C CA   . ASP B 1 112 ? -17.099 -43.632 -51.170 1.00 50.61  ? 99  ASP B CA   1 
ATOM   2568 C C    . ASP B 1 112 ? -17.187 -44.971 -51.907 1.00 50.27  ? 99  ASP B C    1 
ATOM   2569 O O    . ASP B 1 112 ? -16.305 -45.819 -51.737 1.00 47.73  ? 99  ASP B O    1 
ATOM   2570 C CB   . ASP B 1 112 ? -16.298 -43.741 -49.879 1.00 54.07  ? 99  ASP B CB   1 
ATOM   2571 C CG   . ASP B 1 112 ? -16.858 -44.730 -48.875 1.00 59.07  ? 99  ASP B CG   1 
ATOM   2572 O OD1  . ASP B 1 112 ? -18.087 -44.997 -48.935 1.00 56.64  ? 99  ASP B OD1  1 
ATOM   2573 O OD2  . ASP B 1 112 ? -16.052 -45.232 -48.062 1.00 66.36  ? 99  ASP B OD2  1 
ATOM   2574 N N    . ASP B 1 113 ? -18.190 -45.134 -52.791 1.00 45.16  ? 100 ASP B N    1 
ATOM   2575 C CA   . ASP B 1 113 ? -18.229 -46.306 -53.668 1.00 48.09  ? 100 ASP B CA   1 
ATOM   2576 C C    . ASP B 1 113 ? -16.914 -46.412 -54.445 1.00 42.99  ? 100 ASP B C    1 
ATOM   2577 O O    . ASP B 1 113 ? -16.434 -45.420 -54.988 1.00 47.28  ? 100 ASP B O    1 
ATOM   2578 C CB   . ASP B 1 113 ? -19.405 -46.244 -54.636 1.00 52.09  ? 100 ASP B CB   1 
ATOM   2579 N N    . ARG B 1 114 ? -16.310 -47.604 -54.475 1.00 39.58  ? 101 ARG B N    1 
ATOM   2580 C CA   . ARG B 1 114 ? -15.059 -47.835 -55.192 1.00 41.45  ? 101 ARG B CA   1 
ATOM   2581 C C    . ARG B 1 114 ? -15.320 -47.822 -56.697 1.00 41.49  ? 101 ARG B C    1 
ATOM   2582 O O    . ARG B 1 114 ? -16.421 -48.126 -57.133 1.00 48.85  ? 101 ARG B O    1 
ATOM   2583 C CB   . ARG B 1 114 ? -14.318 -49.082 -54.684 1.00 43.97  ? 101 ARG B CB   1 
ATOM   2584 N N    . HIS B 1 115 ? -14.328 -47.388 -57.484 1.00 47.24  ? 102 HIS B N    1 
ATOM   2585 C CA   . HIS B 1 115 ? -14.462 -47.279 -58.931 1.00 39.95  ? 102 HIS B CA   1 
ATOM   2586 C C    . HIS B 1 115 ? -13.072 -47.192 -59.561 1.00 46.38  ? 102 HIS B C    1 
ATOM   2587 O O    . HIS B 1 115 ? -12.227 -46.437 -59.090 1.00 45.60  ? 102 HIS B O    1 
ATOM   2588 C CB   . HIS B 1 115 ? -15.361 -46.085 -59.297 1.00 44.70  ? 102 HIS B CB   1 
ATOM   2589 C CG   . HIS B 1 115 ? -15.000 -44.732 -58.746 1.00 46.86  ? 102 HIS B CG   1 
ATOM   2590 N ND1  . HIS B 1 115 ? -15.509 -44.227 -57.568 1.00 47.61  ? 102 HIS B ND1  1 
ATOM   2591 C CD2  . HIS B 1 115 ? -14.234 -43.741 -59.254 1.00 49.34  ? 102 HIS B CD2  1 
ATOM   2592 C CE1  . HIS B 1 115 ? -15.069 -42.980 -57.377 1.00 54.95  ? 102 HIS B CE1  1 
ATOM   2593 N NE2  . HIS B 1 115 ? -14.291 -42.661 -58.401 1.00 44.90  ? 102 HIS B NE2  1 
ATOM   2594 N N    . ALA B 1 116 ? -12.824 -47.958 -60.632 1.00 45.39  ? 103 ALA B N    1 
ATOM   2595 C CA   . ALA B 1 116 ? -11.547 -47.950 -61.332 1.00 40.48  ? 103 ALA B CA   1 
ATOM   2596 C C    . ALA B 1 116 ? -11.398 -46.731 -62.261 1.00 34.68  ? 103 ALA B C    1 
ATOM   2597 O O    . ALA B 1 116 ? -12.365 -46.286 -62.880 1.00 37.00  ? 103 ALA B O    1 
ATOM   2598 C CB   . ALA B 1 116 ? -11.351 -49.266 -62.053 1.00 40.27  ? 103 ALA B CB   1 
ATOM   2599 N N    . LEU B 1 117 ? -10.167 -46.217 -62.397 1.00 35.32  ? 104 LEU B N    1 
ATOM   2600 C CA   . LEU B 1 117 ? -9.892  -45.047 -63.246 1.00 38.10  ? 104 LEU B CA   1 
ATOM   2601 C C    . LEU B 1 117 ? -10.514 -45.197 -64.645 1.00 39.68  ? 104 LEU B C    1 
ATOM   2602 O O    . LEU B 1 117 ? -11.194 -44.299 -65.146 1.00 39.72  ? 104 LEU B O    1 
ATOM   2603 C CB   . LEU B 1 117 ? -8.398  -44.744 -63.329 1.00 37.86  ? 104 LEU B CB   1 
ATOM   2604 N N    . ALA B 1 118 ? -10.280 -46.349 -65.276 1.00 43.39  ? 105 ALA B N    1 
ATOM   2605 C CA   . ALA B 1 118 ? -10.679 -46.573 -66.667 1.00 42.07  ? 105 ALA B CA   1 
ATOM   2606 C C    . ALA B 1 118 ? -12.191 -46.641 -66.835 1.00 41.66  ? 105 ALA B C    1 
ATOM   2607 O O    . ALA B 1 118 ? -12.678 -46.399 -67.938 1.00 42.10  ? 105 ALA B O    1 
ATOM   2608 C CB   . ALA B 1 118 ? -9.994  -47.803 -67.251 1.00 37.99  ? 105 ALA B CB   1 
ATOM   2609 N N    . ASP B 1 119 ? -12.927 -46.947 -65.747 1.00 40.72  ? 106 ASP B N    1 
ATOM   2610 C CA   . ASP B 1 119 ? -14.375 -47.164 -65.786 1.00 42.11  ? 106 ASP B CA   1 
ATOM   2611 C C    . ASP B 1 119 ? -15.183 -45.884 -65.583 1.00 39.71  ? 106 ASP B C    1 
ATOM   2612 O O    . ASP B 1 119 ? -16.351 -45.843 -65.949 1.00 46.55  ? 106 ASP B O    1 
ATOM   2613 C CB   . ASP B 1 119 ? -14.843 -48.241 -64.819 1.00 42.87  ? 106 ASP B CB   1 
ATOM   2614 C CG   . ASP B 1 119 ? -14.292 -49.625 -65.108 1.00 53.98  ? 106 ASP B CG   1 
ATOM   2615 O OD1  . ASP B 1 119 ? -13.933 -49.861 -66.282 1.00 64.82  ? 106 ASP B OD1  1 
ATOM   2616 O OD2  . ASP B 1 119 ? -14.191 -50.446 -64.159 1.00 56.11  ? 106 ASP B OD2  1 
ATOM   2617 N N    . VAL B 1 120 ? -14.576 -44.824 -65.039 1.00 38.95  ? 107 VAL B N    1 
ATOM   2618 C CA   . VAL B 1 120 ? -15.328 -43.605 -64.764 1.00 33.02  ? 107 VAL B CA   1 
ATOM   2619 C C    . VAL B 1 120 ? -15.849 -43.009 -66.066 1.00 38.99  ? 107 VAL B C    1 
ATOM   2620 O O    . VAL B 1 120 ? -15.051 -42.705 -66.946 1.00 49.27  ? 107 VAL B O    1 
ATOM   2621 C CB   . VAL B 1 120 ? -14.421 -42.570 -64.081 1.00 32.83  ? 107 VAL B CB   1 
ATOM   2622 C CG1  . VAL B 1 120 ? -15.148 -41.261 -63.875 1.00 27.49  ? 107 VAL B CG1  1 
ATOM   2623 C CG2  . VAL B 1 120 ? -13.798 -43.073 -62.802 1.00 34.90  ? 107 VAL B CG2  1 
ATOM   2624 N N    . SER B 1 121 ? -17.154 -42.727 -66.148 1.00 36.59  ? 108 SER B N    1 
ATOM   2625 C CA   . SER B 1 121 ? -17.725 -42.024 -67.288 1.00 35.65  ? 108 SER B CA   1 
ATOM   2626 C C    . SER B 1 121 ? -17.883 -40.562 -66.889 1.00 35.09  ? 108 SER B C    1 
ATOM   2627 O O    . SER B 1 121 ? -17.755 -40.244 -65.709 1.00 32.36  ? 108 SER B O    1 
ATOM   2628 C CB   . SER B 1 121 ? -19.079 -42.594 -67.600 1.00 33.53  ? 108 SER B CB   1 
ATOM   2629 O OG   . SER B 1 121 ? -19.958 -42.138 -66.587 1.00 37.64  ? 108 SER B OG   1 
ATOM   2630 N N    . VAL B 1 122 ? -18.270 -39.701 -67.834 1.00 33.95  ? 109 VAL B N    1 
ATOM   2631 C CA   . VAL B 1 122 ? -18.475 -38.285 -67.545 1.00 32.47  ? 109 VAL B CA   1 
ATOM   2632 C C    . VAL B 1 122 ? -19.632 -38.091 -66.571 1.00 42.04  ? 109 VAL B C    1 
ATOM   2633 O O    . VAL B 1 122 ? -19.614 -37.213 -65.700 1.00 35.97  ? 109 VAL B O    1 
ATOM   2634 C CB   . VAL B 1 122 ? -18.692 -37.449 -68.812 1.00 33.90  ? 109 VAL B CB   1 
ATOM   2635 C CG1  . VAL B 1 122 ? -18.861 -35.974 -68.466 1.00 32.11  ? 109 VAL B CG1  1 
ATOM   2636 C CG2  . VAL B 1 122 ? -17.561 -37.628 -69.836 1.00 33.41  ? 109 VAL B CG2  1 
ATOM   2637 N N    . GLU B 1 123 ? -20.690 -38.901 -66.747 1.00 46.45  ? 110 GLU B N    1 
ATOM   2638 C CA   . GLU B 1 123 ? -21.869 -38.842 -65.894 1.00 40.71  ? 110 GLU B CA   1 
ATOM   2639 C C    . GLU B 1 123 ? -21.484 -39.221 -64.449 1.00 33.12  ? 110 GLU B C    1 
ATOM   2640 O O    . GLU B 1 123 ? -21.879 -38.549 -63.508 1.00 34.29  ? 110 GLU B O    1 
ATOM   2641 C CB   . GLU B 1 123 ? -22.958 -39.738 -66.498 1.00 42.21  ? 110 GLU B CB   1 
ATOM   2642 C CG   . GLU B 1 123 ? -23.229 -39.463 -67.982 1.00 50.09  ? 110 GLU B CG   1 
ATOM   2643 N N    . TYR B 1 124 ? -20.708 -40.302 -64.289 1.00 33.71  ? 111 TYR B N    1 
ATOM   2644 C CA   . TYR B 1 124 ? -20.370 -40.801 -62.969 1.00 37.70  ? 111 TYR B CA   1 
ATOM   2645 C C    . TYR B 1 124 ? -19.499 -39.787 -62.231 1.00 37.64  ? 111 TYR B C    1 
ATOM   2646 O O    . TYR B 1 124 ? -19.623 -39.615 -61.018 1.00 33.95  ? 111 TYR B O    1 
ATOM   2647 C CB   . TYR B 1 124 ? -19.580 -42.095 -63.176 1.00 42.61  ? 111 TYR B CB   1 
ATOM   2648 C CG   . TYR B 1 124 ? -19.262 -42.803 -61.871 1.00 48.77  ? 111 TYR B CG   1 
ATOM   2649 C CD1  . TYR B 1 124 ? -18.147 -42.445 -61.117 1.00 42.78  ? 111 TYR B CD1  1 
ATOM   2650 C CD2  . TYR B 1 124 ? -20.100 -43.808 -61.380 1.00 47.75  ? 111 TYR B CD2  1 
ATOM   2651 C CE1  . TYR B 1 124 ? -17.878 -43.082 -59.917 1.00 54.02  ? 111 TYR B CE1  1 
ATOM   2652 C CE2  . TYR B 1 124 ? -19.840 -44.450 -60.179 1.00 49.73  ? 111 TYR B CE2  1 
ATOM   2653 C CZ   . TYR B 1 124 ? -18.723 -44.080 -59.445 1.00 54.86  ? 111 TYR B CZ   1 
ATOM   2654 O OH   . TYR B 1 124 ? -18.431 -44.711 -58.270 1.00 51.01  ? 111 TYR B OH   1 
ATOM   2655 N N    . TRP B 1 125 ? -18.584 -39.153 -62.974 1.00 38.96  ? 112 TRP B N    1 
ATOM   2656 C CA   . TRP B 1 125 ? -17.649 -38.177 -62.441 1.00 34.35  ? 112 TRP B CA   1 
ATOM   2657 C C    . TRP B 1 125 ? -18.451 -37.009 -61.896 1.00 30.99  ? 112 TRP B C    1 
ATOM   2658 O O    . TRP B 1 125 ? -18.236 -36.585 -60.761 1.00 31.99  ? 112 TRP B O    1 
ATOM   2659 C CB   . TRP B 1 125 ? -16.685 -37.650 -63.523 1.00 33.42  ? 112 TRP B CB   1 
ATOM   2660 C CG   . TRP B 1 125 ? -15.941 -36.421 -63.054 1.00 34.71  ? 112 TRP B CG   1 
ATOM   2661 C CD1  . TRP B 1 125 ? -16.374 -35.121 -63.083 1.00 33.43  ? 112 TRP B CD1  1 
ATOM   2662 C CD2  . TRP B 1 125 ? -14.630 -36.391 -62.453 1.00 30.09  ? 112 TRP B CD2  1 
ATOM   2663 N NE1  . TRP B 1 125 ? -15.431 -34.285 -62.545 1.00 34.08  ? 112 TRP B NE1  1 
ATOM   2664 C CE2  . TRP B 1 125 ? -14.344 -35.036 -62.168 1.00 32.28  ? 112 TRP B CE2  1 
ATOM   2665 C CE3  . TRP B 1 125 ? -13.679 -37.367 -62.140 1.00 28.94  ? 112 TRP B CE3  1 
ATOM   2666 C CZ2  . TRP B 1 125 ? -13.139 -34.649 -61.578 1.00 34.38  ? 112 TRP B CZ2  1 
ATOM   2667 C CZ3  . TRP B 1 125 ? -12.493 -36.990 -61.541 1.00 32.30  ? 112 TRP B CZ3  1 
ATOM   2668 C CH2  . TRP B 1 125 ? -12.228 -35.642 -61.276 1.00 34.22  ? 112 TRP B CH2  1 
ATOM   2669 N N    . ASP B 1 126 ? -19.364 -36.497 -62.719 1.00 34.37  ? 113 ASP B N    1 
ATOM   2670 C CA   . ASP B 1 126 ? -20.105 -35.295 -62.361 1.00 34.72  ? 113 ASP B CA   1 
ATOM   2671 C C    . ASP B 1 126 ? -20.966 -35.570 -61.128 1.00 37.50  ? 113 ASP B C    1 
ATOM   2672 O O    . ASP B 1 126 ? -21.073 -34.715 -60.244 1.00 43.03  ? 113 ASP B O    1 
ATOM   2673 C CB   . ASP B 1 126 ? -20.989 -34.806 -63.503 1.00 44.75  ? 113 ASP B CB   1 
ATOM   2674 C CG   . ASP B 1 126 ? -20.298 -34.070 -64.649 1.00 53.18  ? 113 ASP B CG   1 
ATOM   2675 O OD1  . ASP B 1 126 ? -19.101 -33.731 -64.514 1.00 42.27  ? 113 ASP B OD1  1 
ATOM   2676 O OD2  . ASP B 1 126 ? -20.970 -33.843 -65.679 1.00 54.37  ? 113 ASP B OD2  1 
ATOM   2677 N N    . GLU B 1 127 ? -21.598 -36.752 -61.093 1.00 31.47  ? 114 GLU B N    1 
ATOM   2678 C CA   . GLU B 1 127 ? -22.526 -37.055 -60.008 1.00 37.88  ? 114 GLU B CA   1 
ATOM   2679 C C    . GLU B 1 127 ? -21.739 -37.204 -58.698 1.00 35.08  ? 114 GLU B C    1 
ATOM   2680 O O    . GLU B 1 127 ? -22.161 -36.703 -57.652 1.00 40.98  ? 114 GLU B O    1 
ATOM   2681 C CB   . GLU B 1 127 ? -23.405 -38.282 -60.300 1.00 41.27  ? 114 GLU B CB   1 
ATOM   2682 N N    . ARG B 1 128 ? -20.583 -37.875 -58.789 1.00 32.66  ? 115 ARG B N    1 
ATOM   2683 C CA   . ARG B 1 128 ? -19.719 -38.108 -57.643 1.00 34.97  ? 115 ARG B CA   1 
ATOM   2684 C C    . ARG B 1 128 ? -19.219 -36.782 -57.087 1.00 38.48  ? 115 ARG B C    1 
ATOM   2685 O O    . ARG B 1 128 ? -19.156 -36.625 -55.870 1.00 35.35  ? 115 ARG B O    1 
ATOM   2686 C CB   . ARG B 1 128 ? -18.641 -39.163 -57.880 1.00 38.15  ? 115 ARG B CB   1 
ATOM   2687 C CG   . ARG B 1 128 ? -19.216 -40.565 -57.769 1.00 39.43  ? 115 ARG B CG   1 
ATOM   2688 C CD   . ARG B 1 128 ? -20.233 -40.818 -56.668 1.00 40.70  ? 115 ARG B CD   1 
ATOM   2689 N NE   . ARG B 1 128 ? -20.416 -42.256 -56.452 1.00 46.83  ? 115 ARG B NE   1 
ATOM   2690 N N    . MET B 1 129 ? -18.965 -35.814 -57.975 1.00 36.52  ? 116 MET B N    1 
ATOM   2691 C CA   . MET B 1 129 ? -18.469 -34.514 -57.557 1.00 40.58  ? 116 MET B CA   1 
ATOM   2692 C C    . MET B 1 129 ? -19.578 -33.717 -56.889 1.00 38.75  ? 116 MET B C    1 
ATOM   2693 O O    . MET B 1 129 ? -19.319 -32.989 -55.933 1.00 41.29  ? 116 MET B O    1 
ATOM   2694 C CB   . MET B 1 129 ? -17.866 -33.717 -58.722 1.00 40.81  ? 116 MET B CB   1 
ATOM   2695 C CG   . MET B 1 129 ? -16.442 -34.124 -59.073 1.00 39.55  ? 116 MET B CG   1 
ATOM   2696 S SD   . MET B 1 129 ? -15.245 -33.883 -57.734 1.00 43.74  ? 116 MET B SD   1 
ATOM   2697 C CE   . MET B 1 129 ? -14.395 -35.420 -58.129 1.00 33.06  ? 116 MET B CE   1 
ATOM   2698 N N    . GLN B 1 130 ? -20.813 -33.882 -57.393 1.00 42.06  ? 117 GLN B N    1 
ATOM   2699 C CA   . GLN B 1 130 ? -21.971 -33.201 -56.823 1.00 39.63  ? 117 GLN B CA   1 
ATOM   2700 C C    . GLN B 1 130 ? -22.299 -33.736 -55.421 1.00 36.43  ? 117 GLN B C    1 
ATOM   2701 O O    . GLN B 1 130 ? -22.659 -32.959 -54.536 1.00 35.16  ? 117 GLN B O    1 
ATOM   2702 C CB   . GLN B 1 130 ? -23.177 -33.315 -57.753 1.00 47.00  ? 117 GLN B CB   1 
ATOM   2703 C CG   . GLN B 1 130 ? -22.984 -32.563 -59.066 1.00 53.41  ? 117 GLN B CG   1 
ATOM   2704 C CD   . GLN B 1 130 ? -24.024 -32.947 -60.082 1.00 53.71  ? 117 GLN B CD   1 
ATOM   2705 O OE1  . GLN B 1 130 ? -24.156 -34.112 -60.457 1.00 65.69  ? 117 GLN B OE1  1 
ATOM   2706 N NE2  . GLN B 1 130 ? -24.821 -31.977 -60.489 1.00 57.43  ? 117 GLN B NE2  1 
ATOM   2707 N N    . THR B 1 131 ? -22.140 -35.052 -55.243 1.00 30.95  ? 118 THR B N    1 
ATOM   2708 C CA   . THR B 1 131 ? -22.406 -35.789 -54.012 1.00 38.70  ? 118 THR B CA   1 
ATOM   2709 C C    . THR B 1 131 ? -21.308 -35.605 -52.952 1.00 40.78  ? 118 THR B C    1 
ATOM   2710 O O    . THR B 1 131 ? -21.592 -35.674 -51.739 1.00 36.13  ? 118 THR B O    1 
ATOM   2711 C CB   . THR B 1 131 ? -22.529 -37.257 -54.420 1.00 44.30  ? 118 THR B CB   1 
ATOM   2712 O OG1  . THR B 1 131 ? -23.918 -37.385 -54.705 1.00 57.17  ? 118 THR B OG1  1 
ATOM   2713 C CG2  . THR B 1 131 ? -22.153 -38.242 -53.333 1.00 50.31  ? 118 THR B CG2  1 
ATOM   2714 N N    . ASN B 1 132 ? -20.046 -35.425 -53.399 1.00 37.96  ? 119 ASN B N    1 
ATOM   2715 C CA   . ASN B 1 132 ? -18.868 -35.448 -52.526 1.00 33.11  ? 119 ASN B CA   1 
ATOM   2716 C C    . ASN B 1 132 ? -18.265 -34.056 -52.287 1.00 36.52  ? 119 ASN B C    1 
ATOM   2717 O O    . ASN B 1 132 ? -17.612 -33.860 -51.260 1.00 32.78  ? 119 ASN B O    1 
ATOM   2718 C CB   . ASN B 1 132 ? -17.821 -36.452 -52.988 1.00 40.03  ? 119 ASN B CB   1 
ATOM   2719 C CG   . ASN B 1 132 ? -18.240 -37.882 -52.698 1.00 55.48  ? 119 ASN B CG   1 
ATOM   2720 O OD1  . ASN B 1 132 ? -17.988 -38.388 -51.605 1.00 54.75  ? 119 ASN B OD1  1 
ATOM   2721 N ND2  . ASN B 1 132 ? -18.937 -38.545 -53.610 1.00 65.61  ? 119 ASN B ND2  1 
ATOM   2722 N N    . LEU B 1 133 ? -18.452 -33.099 -53.204 1.00 30.41  ? 120 LEU B N    1 
ATOM   2723 C CA   . LEU B 1 133 ? -17.763 -31.815 -53.082 1.00 29.82  ? 120 LEU B CA   1 
ATOM   2724 C C    . LEU B 1 133 ? -18.707 -30.612 -53.095 1.00 30.97  ? 120 LEU B C    1 
ATOM   2725 O O    . LEU B 1 133 ? -18.598 -29.710 -52.251 1.00 27.48  ? 120 LEU B O    1 
ATOM   2726 C CB   . LEU B 1 133 ? -16.716 -31.658 -54.191 1.00 27.42  ? 120 LEU B CB   1 
ATOM   2727 C CG   . LEU B 1 133 ? -15.950 -30.333 -54.185 1.00 27.10  ? 120 LEU B CG   1 
ATOM   2728 C CD1  . LEU B 1 133 ? -15.156 -30.114 -52.906 1.00 24.62  ? 120 LEU B CD1  1 
ATOM   2729 C CD2  . LEU B 1 133 ? -15.056 -30.102 -55.414 1.00 28.19  ? 120 LEU B CD2  1 
ATOM   2730 N N    . ARG B 1 134 ? -19.599 -30.552 -54.099 1.00 33.53  ? 121 ARG B N    1 
ATOM   2731 C CA   . ARG B 1 134 ? -20.217 -29.275 -54.469 1.00 29.26  ? 121 ARG B CA   1 
ATOM   2732 C C    . ARG B 1 134 ? -21.068 -28.734 -53.317 1.00 30.26  ? 121 ARG B C    1 
ATOM   2733 O O    . ARG B 1 134 ? -21.135 -27.518 -53.081 1.00 31.33  ? 121 ARG B O    1 
ATOM   2734 C CB   . ARG B 1 134 ? -21.119 -29.469 -55.692 1.00 28.55  ? 121 ARG B CB   1 
ATOM   2735 C CG   . ARG B 1 134 ? -21.687 -28.156 -56.214 1.00 33.27  ? 121 ARG B CG   1 
ATOM   2736 C CD   . ARG B 1 134 ? -22.508 -28.339 -57.503 1.00 35.57  ? 121 ARG B CD   1 
ATOM   2737 N NE   . ARG B 1 134 ? -23.676 -29.224 -57.373 1.00 36.32  ? 121 ARG B NE   1 
ATOM   2738 C CZ   . ARG B 1 134 ? -24.572 -29.502 -58.336 1.00 37.71  ? 121 ARG B CZ   1 
ATOM   2739 N NH1  . ARG B 1 134 ? -25.618 -30.260 -58.071 1.00 35.64  ? 121 ARG B NH1  1 
ATOM   2740 N NH2  . ARG B 1 134 ? -24.439 -29.006 -59.550 1.00 32.08  ? 121 ARG B NH2  1 
ATOM   2741 N N    . HIS B 1 135 ? -21.743 -29.655 -52.611 1.00 29.96  ? 122 HIS B N    1 
ATOM   2742 C CA   . HIS B 1 135 ? -22.681 -29.297 -51.563 1.00 34.82  ? 122 HIS B CA   1 
ATOM   2743 C C    . HIS B 1 135 ? -21.936 -28.632 -50.412 1.00 38.96  ? 122 HIS B C    1 
ATOM   2744 O O    . HIS B 1 135 ? -22.469 -27.717 -49.778 1.00 34.13  ? 122 HIS B O    1 
ATOM   2745 C CB   . HIS B 1 135 ? -23.495 -30.524 -51.122 1.00 33.35  ? 122 HIS B CB   1 
ATOM   2746 C CG   . HIS B 1 135 ? -22.694 -31.639 -50.553 1.00 28.02  ? 122 HIS B CG   1 
ATOM   2747 N ND1  . HIS B 1 135 ? -22.263 -31.685 -49.243 1.00 28.11  ? 122 HIS B ND1  1 
ATOM   2748 C CD2  . HIS B 1 135 ? -22.287 -32.782 -51.125 1.00 29.30  ? 122 HIS B CD2  1 
ATOM   2749 C CE1  . HIS B 1 135 ? -21.610 -32.823 -49.031 1.00 27.91  ? 122 HIS B CE1  1 
ATOM   2750 N NE2  . HIS B 1 135 ? -21.605 -33.492 -50.181 1.00 30.91  ? 122 HIS B NE2  1 
ATOM   2751 N N    . ALA B 1 136 ? -20.700 -29.094 -50.157 1.00 34.60  ? 123 ALA B N    1 
ATOM   2752 C CA   . ALA B 1 136 ? -19.973 -28.528 -49.039 1.00 34.35  ? 123 ALA B CA   1 
ATOM   2753 C C    . ALA B 1 136 ? -19.789 -27.031 -49.282 1.00 29.28  ? 123 ALA B C    1 
ATOM   2754 O O    . ALA B 1 136 ? -19.830 -26.237 -48.346 1.00 35.22  ? 123 ALA B O    1 
ATOM   2755 C CB   . ALA B 1 136 ? -18.673 -29.285 -48.784 1.00 34.42  ? 123 ALA B CB   1 
ATOM   2756 N N    . PHE B 1 137 ? -19.629 -26.635 -50.540 1.00 28.15  ? 124 PHE B N    1 
ATOM   2757 C CA   . PHE B 1 137 ? -19.365 -25.227 -50.830 1.00 30.68  ? 124 PHE B CA   1 
ATOM   2758 C C    . PHE B 1 137 ? -20.649 -24.428 -50.633 1.00 33.95  ? 124 PHE B C    1 
ATOM   2759 O O    . PHE B 1 137 ? -20.636 -23.376 -50.006 1.00 35.17  ? 124 PHE B O    1 
ATOM   2760 C CB   . PHE B 1 137 ? -18.773 -24.924 -52.223 1.00 29.82  ? 124 PHE B CB   1 
ATOM   2761 C CG   . PHE B 1 137 ? -18.849 -23.441 -52.591 1.00 27.52  ? 124 PHE B CG   1 
ATOM   2762 C CD1  . PHE B 1 137 ? -17.985 -22.514 -52.025 1.00 28.70  ? 124 PHE B CD1  1 
ATOM   2763 C CD2  . PHE B 1 137 ? -19.847 -22.972 -53.434 1.00 28.43  ? 124 PHE B CD2  1 
ATOM   2764 C CE1  . PHE B 1 137 ? -18.103 -21.155 -52.295 1.00 28.91  ? 124 PHE B CE1  1 
ATOM   2765 C CE2  . PHE B 1 137 ? -19.955 -21.614 -53.718 1.00 27.17  ? 124 PHE B CE2  1 
ATOM   2766 C CZ   . PHE B 1 137 ? -19.082 -20.716 -53.171 1.00 28.13  ? 124 PHE B CZ   1 
ATOM   2767 N N    . PHE B 1 138 ? -21.752 -24.929 -51.195 1.00 31.97  ? 125 PHE B N    1 
ATOM   2768 C CA   . PHE B 1 138 ? -23.030 -24.241 -51.165 1.00 34.24  ? 125 PHE B CA   1 
ATOM   2769 C C    . PHE B 1 138 ? -23.584 -24.189 -49.736 1.00 35.67  ? 125 PHE B C    1 
ATOM   2770 O O    . PHE B 1 138 ? -24.075 -23.149 -49.307 1.00 36.18  ? 125 PHE B O    1 
ATOM   2771 C CB   . PHE B 1 138 ? -23.973 -24.782 -52.250 1.00 30.60  ? 125 PHE B CB   1 
ATOM   2772 C CG   . PHE B 1 138 ? -23.546 -24.302 -53.624 1.00 32.39  ? 125 PHE B CG   1 
ATOM   2773 C CD1  . PHE B 1 138 ? -23.660 -22.963 -53.972 1.00 33.66  ? 125 PHE B CD1  1 
ATOM   2774 C CD2  . PHE B 1 138 ? -22.947 -25.173 -54.533 1.00 36.27  ? 125 PHE B CD2  1 
ATOM   2775 C CE1  . PHE B 1 138 ? -23.249 -22.511 -55.217 1.00 37.85  ? 125 PHE B CE1  1 
ATOM   2776 C CE2  . PHE B 1 138 ? -22.548 -24.715 -55.786 1.00 38.30  ? 125 PHE B CE2  1 
ATOM   2777 C CZ   . PHE B 1 138 ? -22.679 -23.382 -56.111 1.00 36.74  ? 125 PHE B CZ   1 
ATOM   2778 N N    . ALA B 1 139 ? -23.434 -25.282 -48.978 1.00 35.17  ? 126 ALA B N    1 
ATOM   2779 C CA   . ALA B 1 139 ? -23.820 -25.266 -47.568 1.00 37.11  ? 126 ALA B CA   1 
ATOM   2780 C C    . ALA B 1 139 ? -23.073 -24.166 -46.822 1.00 36.22  ? 126 ALA B C    1 
ATOM   2781 O O    . ALA B 1 139 ? -23.680 -23.411 -46.055 1.00 39.84  ? 126 ALA B O    1 
ATOM   2782 C CB   . ALA B 1 139 ? -23.667 -26.617 -46.898 1.00 30.08  ? 126 ALA B CB   1 
ATOM   2783 N N    . ALA B 1 140 ? -21.766 -24.035 -47.095 1.00 35.41  ? 127 ALA B N    1 
ATOM   2784 C CA   . ALA B 1 140 ? -20.959 -23.006 -46.445 1.00 31.71  ? 127 ALA B CA   1 
ATOM   2785 C C    . ALA B 1 140 ? -21.439 -21.625 -46.879 1.00 31.85  ? 127 ALA B C    1 
ATOM   2786 O O    . ALA B 1 140 ? -21.627 -20.733 -46.050 1.00 35.70  ? 127 ALA B O    1 
ATOM   2787 C CB   . ALA B 1 140 ? -19.485 -23.213 -46.758 1.00 32.58  ? 127 ALA B CB   1 
ATOM   2788 N N    . GLN B 1 141 ? -21.699 -21.477 -48.183 1.00 31.44  ? 128 GLN B N    1 
ATOM   2789 C CA   . GLN B 1 141 ? -22.202 -20.211 -48.717 1.00 33.48  ? 128 GLN B CA   1 
ATOM   2790 C C    . GLN B 1 141 ? -23.546 -19.830 -48.075 1.00 35.13  ? 128 GLN B C    1 
ATOM   2791 O O    . GLN B 1 141 ? -23.813 -18.657 -47.843 1.00 30.83  ? 128 GLN B O    1 
ATOM   2792 C CB   . GLN B 1 141 ? -22.285 -20.275 -50.243 1.00 36.05  ? 128 GLN B CB   1 
ATOM   2793 C CG   . GLN B 1 141 ? -22.654 -18.955 -50.903 1.00 38.27  ? 128 GLN B CG   1 
ATOM   2794 C CD   . GLN B 1 141 ? -23.200 -19.143 -52.300 1.00 41.93  ? 128 GLN B CD   1 
ATOM   2795 O OE1  . GLN B 1 141 ? -24.105 -19.958 -52.531 1.00 39.27  ? 128 GLN B OE1  1 
ATOM   2796 N NE2  . GLN B 1 141 ? -22.600 -18.441 -53.252 1.00 40.52  ? 128 GLN B NE2  1 
ATOM   2797 N N    . ALA B 1 142 ? -24.391 -20.828 -47.772 1.00 39.55  ? 129 ALA B N    1 
ATOM   2798 C CA   . ALA B 1 142 ? -25.723 -20.575 -47.226 1.00 43.51  ? 129 ALA B CA   1 
ATOM   2799 C C    . ALA B 1 142 ? -25.646 -20.144 -45.755 1.00 42.99  ? 129 ALA B C    1 
ATOM   2800 O O    . ALA B 1 142 ? -26.274 -19.163 -45.356 1.00 48.08  ? 129 ALA B O    1 
ATOM   2801 C CB   . ALA B 1 142 ? -26.605 -21.784 -47.429 1.00 36.32  ? 129 ALA B CB   1 
ATOM   2802 N N    . VAL B 1 143 ? -24.786 -20.799 -44.974 1.00 42.21  ? 130 VAL B N    1 
ATOM   2803 C CA   . VAL B 1 143 ? -24.725 -20.522 -43.544 1.00 34.94  ? 130 VAL B CA   1 
ATOM   2804 C C    . VAL B 1 143 ? -23.984 -19.215 -43.292 1.00 33.33  ? 130 VAL B C    1 
ATOM   2805 O O    . VAL B 1 143 ? -24.241 -18.536 -42.292 1.00 36.99  ? 130 VAL B O    1 
ATOM   2806 C CB   . VAL B 1 143 ? -24.181 -21.692 -42.699 1.00 36.65  ? 130 VAL B CB   1 
ATOM   2807 C CG1  . VAL B 1 143 ? -25.069 -22.926 -42.856 1.00 33.05  ? 130 VAL B CG1  1 
ATOM   2808 C CG2  . VAL B 1 143 ? -22.727 -22.060 -43.027 1.00 36.24  ? 130 VAL B CG2  1 
ATOM   2809 N N    . ALA B 1 144 ? -23.096 -18.834 -44.215 1.00 36.94  ? 131 ALA B N    1 
ATOM   2810 C CA   . ALA B 1 144 ? -22.126 -17.787 -43.931 1.00 35.66  ? 131 ALA B CA   1 
ATOM   2811 C C    . ALA B 1 144 ? -22.811 -16.467 -43.551 1.00 35.37  ? 131 ALA B C    1 
ATOM   2812 O O    . ALA B 1 144 ? -22.432 -15.829 -42.583 1.00 39.68  ? 131 ALA B O    1 
ATOM   2813 C CB   . ALA B 1 144 ? -21.164 -17.632 -45.093 1.00 35.91  ? 131 ALA B CB   1 
ATOM   2814 N N    . PRO B 1 145 ? -23.781 -15.939 -44.317 1.00 45.13  ? 132 PRO B N    1 
ATOM   2815 C CA   . PRO B 1 145 ? -24.270 -14.581 -44.060 1.00 43.09  ? 132 PRO B CA   1 
ATOM   2816 C C    . PRO B 1 145 ? -24.881 -14.396 -42.672 1.00 38.33  ? 132 PRO B C    1 
ATOM   2817 O O    . PRO B 1 145 ? -24.619 -13.393 -42.015 1.00 33.25  ? 132 PRO B O    1 
ATOM   2818 C CB   . PRO B 1 145 ? -25.226 -14.307 -45.219 1.00 49.39  ? 132 PRO B CB   1 
ATOM   2819 C CG   . PRO B 1 145 ? -24.831 -15.337 -46.277 1.00 46.91  ? 132 PRO B CG   1 
ATOM   2820 C CD   . PRO B 1 145 ? -24.395 -16.556 -45.506 1.00 52.31  ? 132 PRO B CD   1 
ATOM   2821 N N    . GLY B 1 146 ? -25.639 -15.404 -42.222 1.00 49.77  ? 133 GLY B N    1 
ATOM   2822 C CA   . GLY B 1 146 ? -26.199 -15.471 -40.877 1.00 47.91  ? 133 GLY B CA   1 
ATOM   2823 C C    . GLY B 1 146 ? -25.108 -15.523 -39.804 1.00 54.36  ? 133 GLY B C    1 
ATOM   2824 O O    . GLY B 1 146 ? -25.185 -14.805 -38.802 1.00 49.68  ? 133 GLY B O    1 
ATOM   2825 N N    . MET B 1 147 ? -24.069 -16.350 -40.022 1.00 39.41  ? 134 MET B N    1 
ATOM   2826 C CA   . MET B 1 147 ? -22.928 -16.369 -39.114 1.00 32.41  ? 134 MET B CA   1 
ATOM   2827 C C    . MET B 1 147 ? -22.329 -14.974 -39.019 1.00 30.46  ? 134 MET B C    1 
ATOM   2828 O O    . MET B 1 147 ? -21.964 -14.516 -37.945 1.00 34.91  ? 134 MET B O    1 
ATOM   2829 C CB   . MET B 1 147 ? -21.846 -17.335 -39.601 1.00 29.32  ? 134 MET B CB   1 
ATOM   2830 C CG   . MET B 1 147 ? -22.212 -18.764 -39.272 1.00 32.15  ? 134 MET B CG   1 
ATOM   2831 S SD   . MET B 1 147 ? -21.057 -19.905 -40.050 1.00 34.26  ? 134 MET B SD   1 
ATOM   2832 C CE   . MET B 1 147 ? -21.824 -21.417 -39.438 1.00 27.44  ? 134 MET B CE   1 
ATOM   2833 N N    . ALA B 1 148 ? -22.237 -14.298 -40.152 1.00 30.19  ? 135 ALA B N    1 
ATOM   2834 C CA   . ALA B 1 148 ? -21.489 -13.055 -40.194 1.00 34.86  ? 135 ALA B CA   1 
ATOM   2835 C C    . ALA B 1 148 ? -22.269 -11.975 -39.449 1.00 38.70  ? 135 ALA B C    1 
ATOM   2836 O O    . ALA B 1 148 ? -21.672 -11.121 -38.807 1.00 42.75  ? 135 ALA B O    1 
ATOM   2837 C CB   . ALA B 1 148 ? -21.227 -12.686 -41.641 1.00 34.05  ? 135 ALA B CB   1 
ATOM   2838 N N    . ARG B 1 149 ? -23.610 -12.039 -39.547 1.00 41.48  ? 136 ARG B N    1 
ATOM   2839 C CA   . ARG B 1 149 ? -24.499 -11.101 -38.872 1.00 51.43  ? 136 ARG B CA   1 
ATOM   2840 C C    . ARG B 1 149 ? -24.222 -11.189 -37.373 1.00 45.59  ? 136 ARG B C    1 
ATOM   2841 O O    . ARG B 1 149 ? -23.993 -10.181 -36.719 1.00 40.41  ? 136 ARG B O    1 
ATOM   2842 C CB   . ARG B 1 149 ? -25.973 -11.343 -39.235 1.00 47.26  ? 136 ARG B CB   1 
ATOM   2843 N N    . ARG B 1 150 ? -24.180 -12.423 -36.853 1.00 47.03  ? 137 ARG B N    1 
ATOM   2844 C CA   . ARG B 1 150 ? -23.853 -12.664 -35.453 1.00 43.38  ? 137 ARG B CA   1 
ATOM   2845 C C    . ARG B 1 150 ? -22.392 -12.276 -35.165 1.00 48.48  ? 137 ARG B C    1 
ATOM   2846 O O    . ARG B 1 150 ? -22.086 -11.788 -34.079 1.00 49.64  ? 137 ARG B O    1 
ATOM   2847 C CB   . ARG B 1 150 ? -24.264 -14.094 -35.063 1.00 38.89  ? 137 ARG B CB   1 
ATOM   2848 C CG   . ARG B 1 150 ? -23.925 -14.495 -33.628 1.00 34.26  ? 137 ARG B CG   1 
ATOM   2849 C CD   . ARG B 1 150 ? -24.353 -15.903 -33.288 1.00 39.82  ? 137 ARG B CD   1 
ATOM   2850 N NE   . ARG B 1 150 ? -23.718 -16.812 -34.249 1.00 42.39  ? 137 ARG B NE   1 
ATOM   2851 C CZ   . ARG B 1 150 ? -24.299 -17.739 -35.004 1.00 37.39  ? 137 ARG B CZ   1 
ATOM   2852 N NH1  . ARG B 1 150 ? -23.568 -18.364 -35.931 1.00 29.95  ? 137 ARG B NH1  1 
ATOM   2853 N NH2  . ARG B 1 150 ? -25.576 -18.044 -34.802 1.00 39.08  ? 137 ARG B NH2  1 
ATOM   2854 N N    . GLY B 1 151 ? -21.479 -12.500 -36.123 1.00 45.20  ? 138 GLY B N    1 
ATOM   2855 C CA   . GLY B 1 151 ? -20.060 -12.236 -35.900 1.00 41.05  ? 138 GLY B CA   1 
ATOM   2856 C C    . GLY B 1 151 ? -19.313 -13.468 -35.379 1.00 37.74  ? 138 GLY B C    1 
ATOM   2857 O O    . GLY B 1 151 ? -18.253 -13.349 -34.788 1.00 37.97  ? 138 GLY B O    1 
ATOM   2858 N N    . SER B 1 152 ? -19.858 -14.663 -35.618 1.00 41.34  ? 139 SER B N    1 
ATOM   2859 C CA   . SER B 1 152 ? -19.239 -15.887 -35.138 1.00 41.63  ? 139 SER B CA   1 
ATOM   2860 C C    . SER B 1 152 ? -19.821 -17.071 -35.889 1.00 35.72  ? 139 SER B C    1 
ATOM   2861 O O    . SER B 1 152 ? -20.951 -16.994 -36.341 1.00 39.11  ? 139 SER B O    1 
ATOM   2862 C CB   . SER B 1 152 ? -19.418 -16.068 -33.626 1.00 40.29  ? 139 SER B CB   1 
ATOM   2863 O OG   . SER B 1 152 ? -20.732 -16.494 -33.299 1.00 36.63  ? 139 SER B OG   1 
ATOM   2864 N N    . GLY B 1 153 ? -19.067 -18.172 -35.929 1.00 32.95  ? 140 GLY B N    1 
ATOM   2865 C CA   . GLY B 1 153 ? -19.565 -19.448 -36.430 1.00 33.02  ? 140 GLY B CA   1 
ATOM   2866 C C    . GLY B 1 153 ? -18.380 -20.362 -36.743 1.00 27.95  ? 140 GLY B C    1 
ATOM   2867 O O    . GLY B 1 153 ? -17.236 -19.910 -36.774 1.00 29.01  ? 140 GLY B O    1 
ATOM   2868 N N    . ALA B 1 154 ? -18.672 -21.646 -36.962 1.00 30.38  ? 141 ALA B N    1 
ATOM   2869 C CA   . ALA B 1 154 ? -17.643 -22.640 -37.155 1.00 30.50  ? 141 ALA B CA   1 
ATOM   2870 C C    . ALA B 1 154 ? -18.102 -23.601 -38.241 1.00 37.07  ? 141 ALA B C    1 
ATOM   2871 O O    . ALA B 1 154 ? -19.253 -24.043 -38.201 1.00 35.40  ? 141 ALA B O    1 
ATOM   2872 C CB   . ALA B 1 154 ? -17.403 -23.366 -35.850 1.00 30.21  ? 141 ALA B CB   1 
ATOM   2873 N N    . ILE B 1 155 ? -17.185 -23.938 -39.165 1.00 30.97  ? 142 ILE B N    1 
ATOM   2874 C CA   . ILE B 1 155 ? -17.451 -24.904 -40.220 1.00 35.27  ? 142 ILE B CA   1 
ATOM   2875 C C    . ILE B 1 155 ? -16.419 -26.021 -40.124 1.00 28.64  ? 142 ILE B C    1 
ATOM   2876 O O    . ILE B 1 155 ? -15.263 -25.764 -39.848 1.00 34.70  ? 142 ILE B O    1 
ATOM   2877 C CB   . ILE B 1 155 ? -17.486 -24.238 -41.618 1.00 32.52  ? 142 ILE B CB   1 
ATOM   2878 C CG1  . ILE B 1 155 ? -18.583 -23.164 -41.672 1.00 32.47  ? 142 ILE B CG1  1 
ATOM   2879 C CG2  . ILE B 1 155 ? -17.702 -25.293 -42.713 1.00 36.34  ? 142 ILE B CG2  1 
ATOM   2880 C CD1  . ILE B 1 155 ? -18.605 -22.337 -42.944 1.00 35.07  ? 142 ILE B CD1  1 
ATOM   2881 N N    . ILE B 1 156 ? -16.859 -27.261 -40.292 1.00 30.52  ? 143 ILE B N    1 
ATOM   2882 C CA   . ILE B 1 156 ? -15.962 -28.401 -40.272 1.00 27.99  ? 143 ILE B CA   1 
ATOM   2883 C C    . ILE B 1 156 ? -16.203 -29.162 -41.566 1.00 28.60  ? 143 ILE B C    1 
ATOM   2884 O O    . ILE B 1 156 ? -17.302 -29.668 -41.781 1.00 29.21  ? 143 ILE B O    1 
ATOM   2885 C CB   . ILE B 1 156 ? -16.259 -29.307 -39.074 1.00 29.15  ? 143 ILE B CB   1 
ATOM   2886 C CG1  . ILE B 1 156 ? -16.142 -28.572 -37.728 1.00 34.48  ? 143 ILE B CG1  1 
ATOM   2887 C CG2  . ILE B 1 156 ? -15.400 -30.583 -39.123 1.00 30.76  ? 143 ILE B CG2  1 
ATOM   2888 C CD1  . ILE B 1 156 ? -16.627 -29.409 -36.550 1.00 28.97  ? 143 ILE B CD1  1 
ATOM   2889 N N    . ASN B 1 157 ? -15.162 -29.274 -42.406 1.00 28.30  ? 144 ASN B N    1 
ATOM   2890 C CA   . ASN B 1 157 ? -15.250 -30.027 -43.633 1.00 26.08  ? 144 ASN B CA   1 
ATOM   2891 C C    . ASN B 1 157 ? -14.692 -31.400 -43.333 1.00 27.56  ? 144 ASN B C    1 
ATOM   2892 O O    . ASN B 1 157 ? -13.592 -31.476 -42.838 1.00 25.97  ? 144 ASN B O    1 
ATOM   2893 C CB   . ASN B 1 157 ? -14.467 -29.354 -44.756 1.00 32.87  ? 144 ASN B CB   1 
ATOM   2894 C CG   . ASN B 1 157 ? -15.103 -28.065 -45.240 1.00 32.51  ? 144 ASN B CG   1 
ATOM   2895 O OD1  . ASN B 1 157 ? -16.330 -27.958 -45.316 1.00 33.54  ? 144 ASN B OD1  1 
ATOM   2896 N ND2  . ASN B 1 157 ? -14.307 -27.065 -45.592 1.00 31.58  ? 144 ASN B ND2  1 
ATOM   2897 N N    . MET B 1 158 ? -15.455 -32.462 -43.575 1.00 23.79  ? 145 MET B N    1 
ATOM   2898 C CA   . MET B 1 158 ? -14.921 -33.803 -43.437 1.00 27.25  ? 145 MET B CA   1 
ATOM   2899 C C    . MET B 1 158 ? -13.975 -34.097 -44.598 1.00 31.05  ? 145 MET B C    1 
ATOM   2900 O O    . MET B 1 158 ? -14.385 -34.212 -45.762 1.00 29.81  ? 145 MET B O    1 
ATOM   2901 C CB   . MET B 1 158 ? -16.052 -34.847 -43.410 1.00 31.35  ? 145 MET B CB   1 
ATOM   2902 C CG   . MET B 1 158 ? -16.975 -34.702 -42.197 1.00 30.20  ? 145 MET B CG   1 
ATOM   2903 S SD   . MET B 1 158 ? -16.127 -35.004 -40.633 1.00 33.88  ? 145 MET B SD   1 
ATOM   2904 C CE   . MET B 1 158 ? -15.675 -36.697 -41.046 1.00 30.38  ? 145 MET B CE   1 
ATOM   2905 N N    . GLY B 1 159 ? -12.687 -34.214 -44.238 1.00 33.12  ? 146 GLY B N    1 
ATOM   2906 C CA   . GLY B 1 159 ? -11.584 -34.563 -45.123 1.00 30.30  ? 146 GLY B CA   1 
ATOM   2907 C C    . GLY B 1 159 ? -11.377 -36.073 -45.093 1.00 35.36  ? 146 GLY B C    1 
ATOM   2908 O O    . GLY B 1 159 ? -12.239 -36.796 -44.624 1.00 28.96  ? 146 GLY B O    1 
ATOM   2909 N N    . SER B 1 160 ? -10.214 -36.533 -45.546 1.00 33.26  ? 147 SER B N    1 
ATOM   2910 C CA   . SER B 1 160 ? -9.905  -37.951 -45.554 1.00 35.30  ? 147 SER B CA   1 
ATOM   2911 C C    . SER B 1 160 ? -8.402  -38.086 -45.769 1.00 36.12  ? 147 SER B C    1 
ATOM   2912 O O    . SER B 1 160 ? -7.805  -37.269 -46.470 1.00 33.38  ? 147 SER B O    1 
ATOM   2913 C CB   . SER B 1 160 ? -10.733 -38.701 -46.600 1.00 32.68  ? 147 SER B CB   1 
ATOM   2914 O OG   . SER B 1 160 ? -10.300 -40.047 -46.743 1.00 34.53  ? 147 SER B OG   1 
ATOM   2915 N N    . ILE B 1 161 ? -7.788  -39.073 -45.112 1.00 31.28  ? 148 ILE B N    1 
ATOM   2916 C CA   . ILE B 1 161 ? -6.368  -39.308 -45.312 1.00 32.62  ? 148 ILE B CA   1 
ATOM   2917 C C    . ILE B 1 161 ? -6.166  -40.066 -46.632 1.00 30.75  ? 148 ILE B C    1 
ATOM   2918 O O    . ILE B 1 161 ? -5.021  -40.287 -47.022 1.00 28.47  ? 148 ILE B O    1 
ATOM   2919 C CB   . ILE B 1 161 ? -5.751  -40.103 -44.135 1.00 34.36  ? 148 ILE B CB   1 
ATOM   2920 C CG1  . ILE B 1 161 ? -6.353  -41.527 -44.051 1.00 34.11  ? 148 ILE B CG1  1 
ATOM   2921 C CG2  . ILE B 1 161 ? -5.892  -39.368 -42.799 1.00 31.02  ? 148 ILE B CG2  1 
ATOM   2922 C CD1  . ILE B 1 161 ? -5.547  -42.501 -43.211 1.00 28.21  ? 148 ILE B CD1  1 
ATOM   2923 N N    . SER B 1 162 ? -7.258  -40.534 -47.273 1.00 32.88  ? 149 SER B N    1 
ATOM   2924 C CA   . SER B 1 162 ? -7.155  -41.323 -48.504 1.00 32.51  ? 149 SER B CA   1 
ATOM   2925 C C    . SER B 1 162 ? -6.310  -40.613 -49.565 1.00 27.87  ? 149 SER B C    1 
ATOM   2926 O O    . SER B 1 162 ? -5.450  -41.220 -50.184 1.00 25.34  ? 149 SER B O    1 
ATOM   2927 C CB   . SER B 1 162 ? -8.528  -41.706 -49.070 1.00 29.24  ? 149 SER B CB   1 
ATOM   2928 O OG   . SER B 1 162 ? -9.298  -40.540 -49.349 1.00 35.08  ? 149 SER B OG   1 
ATOM   2929 N N    . TRP B 1 163 ? -6.579  -39.319 -49.811 1.00 28.58  ? 150 TRP B N    1 
ATOM   2930 C CA   . TRP B 1 163 ? -5.821  -38.672 -50.871 1.00 26.57  ? 150 TRP B CA   1 
ATOM   2931 C C    . TRP B 1 163 ? -4.399  -38.432 -50.404 1.00 24.24  ? 150 TRP B C    1 
ATOM   2932 O O    . TRP B 1 163 ? -3.462  -38.524 -51.205 1.00 30.07  ? 150 TRP B O    1 
ATOM   2933 C CB   . TRP B 1 163 ? -6.488  -37.369 -51.326 1.00 32.24  ? 150 TRP B CB   1 
ATOM   2934 C CG   . TRP B 1 163 ? -6.439  -36.272 -50.298 1.00 28.93  ? 150 TRP B CG   1 
ATOM   2935 C CD1  . TRP B 1 163 ? -7.394  -35.969 -49.371 1.00 28.67  ? 150 TRP B CD1  1 
ATOM   2936 C CD2  . TRP B 1 163 ? -5.361  -35.334 -50.080 1.00 33.88  ? 150 TRP B CD2  1 
ATOM   2937 N NE1  . TRP B 1 163 ? -7.006  -34.883 -48.619 1.00 29.82  ? 150 TRP B NE1  1 
ATOM   2938 C CE2  . TRP B 1 163 ? -5.764  -34.479 -49.027 1.00 30.75  ? 150 TRP B CE2  1 
ATOM   2939 C CE3  . TRP B 1 163 ? -4.106  -35.127 -50.669 1.00 34.22  ? 150 TRP B CE3  1 
ATOM   2940 C CZ2  . TRP B 1 163 ? -4.947  -33.446 -48.556 1.00 36.42  ? 150 TRP B CZ2  1 
ATOM   2941 C CZ3  . TRP B 1 163 ? -3.291  -34.118 -50.180 1.00 35.19  ? 150 TRP B CZ3  1 
ATOM   2942 C CH2  . TRP B 1 163 ? -3.708  -33.286 -49.143 1.00 28.07  ? 150 TRP B CH2  1 
ATOM   2943 N N    . MET B 1 164 ? -4.229  -38.184 -49.100 1.00 27.58  ? 151 MET B N    1 
ATOM   2944 C CA   . MET B 1 164 ? -2.900  -37.974 -48.533 1.00 26.63  ? 151 MET B CA   1 
ATOM   2945 C C    . MET B 1 164 ? -2.004  -39.195 -48.770 1.00 30.11  ? 151 MET B C    1 
ATOM   2946 O O    . MET B 1 164 ? -0.834  -39.057 -49.096 1.00 27.90  ? 151 MET B O    1 
ATOM   2947 C CB   . MET B 1 164 ? -2.982  -37.663 -47.033 1.00 27.15  ? 151 MET B CB   1 
ATOM   2948 C CG   . MET B 1 164 ? -3.521  -36.275 -46.720 1.00 35.02  ? 151 MET B CG   1 
ATOM   2949 S SD   . MET B 1 164 ? -4.109  -36.124 -45.017 1.00 37.07  ? 151 MET B SD   1 
ATOM   2950 C CE   . MET B 1 164 ? -4.700  -34.413 -44.975 1.00 33.75  ? 151 MET B CE   1 
ATOM   2951 N N    . ARG B 1 165 ? -2.568  -40.381 -48.554 1.00 29.61  ? 152 ARG B N    1 
ATOM   2952 C CA   . ARG B 1 165 ? -1.914  -41.666 -48.767 1.00 28.48  ? 152 ARG B CA   1 
ATOM   2953 C C    . ARG B 1 165 ? -2.044  -42.117 -50.226 1.00 29.95  ? 152 ARG B C    1 
ATOM   2954 O O    . ARG B 1 165 ? -1.510  -43.160 -50.597 1.00 28.63  ? 152 ARG B O    1 
ATOM   2955 C CB   . ARG B 1 165 ? -2.744  -42.716 -48.015 1.00 27.27  ? 152 ARG B CB   1 
ATOM   2956 C CG   . ARG B 1 165 ? -2.568  -42.690 -46.506 1.00 30.14  ? 152 ARG B CG   1 
ATOM   2957 C CD   . ARG B 1 165 ? -3.383  -43.852 -45.905 1.00 26.17  ? 152 ARG B CD   1 
ATOM   2958 N NE   . ARG B 1 165 ? -2.676  -45.095 -46.232 1.00 31.29  ? 152 ARG B NE   1 
ATOM   2959 C CZ   . ARG B 1 165 ? -3.168  -46.305 -46.050 1.00 30.65  ? 152 ARG B CZ   1 
ATOM   2960 N NH1  . ARG B 1 165 ? -4.387  -46.445 -45.570 1.00 27.63  ? 152 ARG B NH1  1 
ATOM   2961 N NH2  . ARG B 1 165 ? -2.414  -47.355 -46.344 1.00 34.20  ? 152 ARG B NH2  1 
ATOM   2962 N N    . GLY B 1 166 ? -2.627  -41.266 -51.088 1.00 30.46  ? 153 GLY B N    1 
ATOM   2963 C CA   . GLY B 1 166 ? -2.667  -41.563 -52.518 1.00 32.60  ? 153 GLY B CA   1 
ATOM   2964 C C    . GLY B 1 166 ? -3.379  -42.902 -52.765 1.00 32.14  ? 153 GLY B C    1 
ATOM   2965 O O    . GLY B 1 166 ? -2.894  -43.726 -53.524 1.00 33.29  ? 153 GLY B O    1 
ATOM   2966 N N    . ARG B 1 167 ? -4.520  -43.113 -52.097 1.00 37.50  ? 154 ARG B N    1 
ATOM   2967 C CA   . ARG B 1 167 ? -5.272  -44.365 -52.196 1.00 38.02  ? 154 ARG B CA   1 
ATOM   2968 C C    . ARG B 1 167 ? -5.887  -44.471 -53.588 1.00 40.20  ? 154 ARG B C    1 
ATOM   2969 O O    . ARG B 1 167 ? -6.560  -43.531 -54.048 1.00 31.60  ? 154 ARG B O    1 
ATOM   2970 C CB   . ARG B 1 167 ? -6.391  -44.549 -51.172 1.00 28.71  ? 154 ARG B CB   1 
ATOM   2971 N N    . PRO B 1 168 ? -5.611  -45.597 -54.302 1.00 34.02  ? 155 PRO B N    1 
ATOM   2972 C CA   . PRO B 1 168 ? -6.140  -45.814 -55.637 1.00 33.76  ? 155 PRO B CA   1 
ATOM   2973 C C    . PRO B 1 168 ? -7.564  -46.360 -55.611 1.00 36.40  ? 155 PRO B C    1 
ATOM   2974 O O    . PRO B 1 168 ? -8.023  -46.811 -54.570 1.00 42.52  ? 155 PRO B O    1 
ATOM   2975 C CB   . PRO B 1 168 ? -5.156  -46.841 -56.219 1.00 32.92  ? 155 PRO B CB   1 
ATOM   2976 C CG   . PRO B 1 168 ? -4.909  -47.728 -54.997 1.00 33.29  ? 155 PRO B CG   1 
ATOM   2977 C CD   . PRO B 1 168 ? -4.775  -46.721 -53.844 1.00 33.89  ? 155 PRO B CD   1 
ATOM   2978 N N    . GLY B 1 169 ? -8.276  -46.293 -56.743 1.00 37.10  ? 156 GLY B N    1 
ATOM   2979 C CA   . GLY B 1 169 ? -9.503  -47.069 -56.889 1.00 44.03  ? 156 GLY B CA   1 
ATOM   2980 C C    . GLY B 1 169 ? -10.774 -46.327 -56.471 1.00 43.17  ? 156 GLY B C    1 
ATOM   2981 O O    . GLY B 1 169 ? -11.811 -46.965 -56.288 1.00 48.29  ? 156 GLY B O    1 
ATOM   2982 N N    . MET B 1 170 ? -10.698 -44.991 -56.329 1.00 35.64  ? 157 MET B N    1 
ATOM   2983 C CA   . MET B 1 170 ? -11.880 -44.195 -56.045 1.00 29.38  ? 157 MET B CA   1 
ATOM   2984 C C    . MET B 1 170 ? -11.577 -42.713 -56.286 1.00 35.25  ? 157 MET B C    1 
ATOM   2985 O O    . MET B 1 170 ? -11.851 -41.846 -55.433 1.00 34.64  ? 157 MET B O    1 
ATOM   2986 C CB   . MET B 1 170 ? -12.414 -44.452 -54.633 1.00 40.06  ? 157 MET B CB   1 
ATOM   2987 C CG   . MET B 1 170 ? -11.494 -44.019 -53.532 1.00 41.66  ? 157 MET B CG   1 
ATOM   2988 S SD   . MET B 1 170 ? -12.083 -44.907 -52.086 1.00 56.76  ? 157 MET B SD   1 
ATOM   2989 C CE   . MET B 1 170 ? -10.691 -44.627 -50.980 1.00 51.95  ? 157 MET B CE   1 
ATOM   2990 N N    . VAL B 1 171 ? -11.098 -42.453 -57.510 1.00 35.48  ? 158 VAL B N    1 
ATOM   2991 C CA   . VAL B 1 171 ? -10.545 -41.172 -57.918 1.00 32.52  ? 158 VAL B CA   1 
ATOM   2992 C C    . VAL B 1 171 ? -11.508 -40.035 -57.575 1.00 31.45  ? 158 VAL B C    1 
ATOM   2993 O O    . VAL B 1 171 ? -11.065 -38.976 -57.143 1.00 32.70  ? 158 VAL B O    1 
ATOM   2994 C CB   . VAL B 1 171 ? -10.045 -41.096 -59.377 1.00 29.07  ? 158 VAL B CB   1 
ATOM   2995 C CG1  . VAL B 1 171 ? -11.177 -41.349 -60.372 1.00 26.63  ? 158 VAL B CG1  1 
ATOM   2996 C CG2  . VAL B 1 171 ? -9.389  -39.739 -59.679 1.00 27.45  ? 158 VAL B CG2  1 
ATOM   2997 N N    . CYS B 1 172 ? -12.817 -40.221 -57.787 1.00 30.91  ? 159 CYS B N    1 
ATOM   2998 C CA   . CYS B 1 172 ? -13.752 -39.121 -57.599 1.00 30.19  ? 159 CYS B CA   1 
ATOM   2999 C C    . CYS B 1 172 ? -13.832 -38.694 -56.137 1.00 37.20  ? 159 CYS B C    1 
ATOM   3000 O O    . CYS B 1 172 ? -13.943 -37.496 -55.840 1.00 41.82  ? 159 CYS B O    1 
ATOM   3001 C CB   . CYS B 1 172 ? -15.144 -39.454 -58.114 1.00 36.11  ? 159 CYS B CB   1 
ATOM   3002 S SG   . CYS B 1 172 ? -15.189 -39.668 -59.915 1.00 41.94  ? 159 CYS B SG   1 
ATOM   3003 N N    . TYR B 1 173 ? -13.801 -39.689 -55.242 1.00 37.07  ? 160 TYR B N    1 
ATOM   3004 C CA   . TYR B 1 173 ? -13.925 -39.503 -53.804 1.00 36.99  ? 160 TYR B CA   1 
ATOM   3005 C C    . TYR B 1 173 ? -12.656 -38.846 -53.256 1.00 31.65  ? 160 TYR B C    1 
ATOM   3006 O O    . TYR B 1 173 ? -12.745 -37.858 -52.528 1.00 30.01  ? 160 TYR B O    1 
ATOM   3007 C CB   . TYR B 1 173 ? -14.161 -40.859 -53.114 1.00 36.90  ? 160 TYR B CB   1 
ATOM   3008 C CG   . TYR B 1 173 ? -14.144 -40.788 -51.594 1.00 39.56  ? 160 TYR B CG   1 
ATOM   3009 C CD1  . TYR B 1 173 ? -15.285 -40.425 -50.878 1.00 38.12  ? 160 TYR B CD1  1 
ATOM   3010 C CD2  . TYR B 1 173 ? -12.990 -41.100 -50.882 1.00 35.77  ? 160 TYR B CD2  1 
ATOM   3011 C CE1  . TYR B 1 173 ? -15.271 -40.340 -49.495 1.00 41.69  ? 160 TYR B CE1  1 
ATOM   3012 C CE2  . TYR B 1 173 ? -12.967 -41.016 -49.495 1.00 39.98  ? 160 TYR B CE2  1 
ATOM   3013 C CZ   . TYR B 1 173 ? -14.105 -40.634 -48.804 1.00 38.62  ? 160 TYR B CZ   1 
ATOM   3014 O OH   . TYR B 1 173 ? -14.058 -40.563 -47.439 1.00 43.08  ? 160 TYR B OH   1 
ATOM   3015 N N    . THR B 1 174 ? -11.495 -39.393 -53.638 1.00 31.98  ? 161 THR B N    1 
ATOM   3016 C CA   . THR B 1 174 ? -10.208 -38.916 -53.139 1.00 30.72  ? 161 THR B CA   1 
ATOM   3017 C C    . THR B 1 174 ? -9.983  -37.494 -53.661 1.00 27.80  ? 161 THR B C    1 
ATOM   3018 O O    . THR B 1 174 ? -9.508  -36.646 -52.917 1.00 28.76  ? 161 THR B O    1 
ATOM   3019 C CB   . THR B 1 174 ? -9.064  -39.877 -53.472 1.00 32.33  ? 161 THR B CB   1 
ATOM   3020 O OG1  . THR B 1 174 ? -9.088  -40.117 -54.877 1.00 31.63  ? 161 THR B OG1  1 
ATOM   3021 C CG2  . THR B 1 174 ? -9.132  -41.186 -52.704 1.00 29.35  ? 161 THR B CG2  1 
ATOM   3022 N N    . THR B 1 175 ? -10.476 -37.216 -54.874 1.00 25.93  ? 162 THR B N    1 
ATOM   3023 C CA   . THR B 1 175 ? -10.220 -35.936 -55.508 1.00 28.32  ? 162 THR B CA   1 
ATOM   3024 C C    . THR B 1 175 ? -11.076 -34.867 -54.840 1.00 32.62  ? 162 THR B C    1 
ATOM   3025 O O    . THR B 1 175 ? -10.620 -33.729 -54.629 1.00 30.27  ? 162 THR B O    1 
ATOM   3026 C CB   . THR B 1 175 ? -10.418 -35.969 -57.025 1.00 26.84  ? 162 THR B CB   1 
ATOM   3027 O OG1  . THR B 1 175 ? -9.530  -36.927 -57.592 1.00 29.24  ? 162 THR B OG1  1 
ATOM   3028 C CG2  . THR B 1 175 ? -10.087 -34.622 -57.665 1.00 25.86  ? 162 THR B CG2  1 
ATOM   3029 N N    . ALA B 1 176 ? -12.336 -35.231 -54.540 1.00 28.64  ? 163 ALA B N    1 
ATOM   3030 C CA   . ALA B 1 176 ? -13.251 -34.343 -53.820 1.00 31.15  ? 163 ALA B CA   1 
ATOM   3031 C C    . ALA B 1 176 ? -12.693 -33.971 -52.443 1.00 29.18  ? 163 ALA B C    1 
ATOM   3032 O O    . ALA B 1 176 ? -12.746 -32.788 -52.020 1.00 29.08  ? 163 ALA B O    1 
ATOM   3033 C CB   . ALA B 1 176 ? -14.625 -34.999 -53.671 1.00 27.09  ? 163 ALA B CB   1 
ATOM   3034 N N    . LYS B 1 177 ? -12.244 -35.011 -51.729 1.00 23.96  ? 164 LYS B N    1 
ATOM   3035 C CA   . LYS B 1 177 ? -11.622 -34.865 -50.422 1.00 27.68  ? 164 LYS B CA   1 
ATOM   3036 C C    . LYS B 1 177 ? -10.419 -33.911 -50.488 1.00 31.73  ? 164 LYS B C    1 
ATOM   3037 O O    . LYS B 1 177 ? -10.267 -33.066 -49.614 1.00 33.51  ? 164 LYS B O    1 
ATOM   3038 C CB   . LYS B 1 177 ? -11.338 -36.231 -49.772 1.00 31.05  ? 164 LYS B CB   1 
ATOM   3039 C CG   . LYS B 1 177 ? -12.571 -37.082 -49.362 1.00 29.31  ? 164 LYS B CG   1 
ATOM   3040 C CD   . LYS B 1 177 ? -13.585 -36.318 -48.492 1.00 37.91  ? 164 LYS B CD   1 
ATOM   3041 C CE   . LYS B 1 177 ? -14.790 -37.052 -47.864 1.00 40.01  ? 164 LYS B CE   1 
ATOM   3042 N NZ   . LYS B 1 177 ? -15.747 -36.094 -47.271 1.00 33.03  ? 164 LYS B NZ   1 
ATOM   3043 N N    . ALA B 1 178 ? -9.536  -34.089 -51.481 1.00 28.97  ? 165 ALA B N    1 
ATOM   3044 C CA   . ALA B 1 178 ? -8.382  -33.209 -51.681 1.00 28.61  ? 165 ALA B CA   1 
ATOM   3045 C C    . ALA B 1 178 ? -8.827  -31.770 -51.904 1.00 27.00  ? 165 ALA B C    1 
ATOM   3046 O O    . ALA B 1 178 ? -8.171  -30.835 -51.453 1.00 30.43  ? 165 ALA B O    1 
ATOM   3047 C CB   . ALA B 1 178 ? -7.551  -33.675 -52.849 1.00 24.51  ? 165 ALA B CB   1 
ATOM   3048 N N    . ALA B 1 179 ? -9.919  -31.608 -52.658 1.00 28.20  ? 166 ALA B N    1 
ATOM   3049 C CA   . ALA B 1 179 ? -10.492 -30.324 -52.993 1.00 24.96  ? 166 ALA B CA   1 
ATOM   3050 C C    . ALA B 1 179 ? -10.922 -29.580 -51.730 1.00 27.29  ? 166 ALA B C    1 
ATOM   3051 O O    . ALA B 1 179 ? -10.626 -28.398 -51.566 1.00 28.41  ? 166 ALA B O    1 
ATOM   3052 C CB   . ALA B 1 179 ? -11.644 -30.545 -53.984 1.00 20.77  ? 166 ALA B CB   1 
ATOM   3053 N N    . LEU B 1 180 ? -11.569 -30.301 -50.807 1.00 32.35  ? 167 LEU B N    1 
ATOM   3054 C CA   . LEU B 1 180 ? -12.021 -29.766 -49.520 1.00 33.53  ? 167 LEU B CA   1 
ATOM   3055 C C    . LEU B 1 180 ? -10.847 -29.277 -48.663 1.00 33.61  ? 167 LEU B C    1 
ATOM   3056 O O    . LEU B 1 180 ? -10.979 -28.322 -47.880 1.00 29.62  ? 167 LEU B O    1 
ATOM   3057 C CB   . LEU B 1 180 ? -12.822 -30.841 -48.767 1.00 34.39  ? 167 LEU B CB   1 
ATOM   3058 C CG   . LEU B 1 180 ? -14.241 -31.133 -49.274 1.00 32.27  ? 167 LEU B CG   1 
ATOM   3059 C CD1  . LEU B 1 180 ? -14.944 -32.248 -48.507 1.00 34.05  ? 167 LEU B CD1  1 
ATOM   3060 C CD2  . LEU B 1 180 ? -15.100 -29.901 -49.196 1.00 28.15  ? 167 LEU B CD2  1 
ATOM   3061 N N    . ASN B 1 181 ? -9.700  -29.964 -48.788 1.00 26.36  ? 168 ASN B N    1 
ATOM   3062 C CA   . ASN B 1 181 ? -8.475  -29.552 -48.127 1.00 27.78  ? 168 ASN B CA   1 
ATOM   3063 C C    . ASN B 1 181 ? -8.132  -28.113 -48.512 1.00 28.96  ? 168 ASN B C    1 
ATOM   3064 O O    . ASN B 1 181 ? -7.813  -27.289 -47.651 1.00 30.86  ? 168 ASN B O    1 
ATOM   3065 C CB   . ASN B 1 181 ? -7.339  -30.498 -48.493 1.00 31.21  ? 168 ASN B CB   1 
ATOM   3066 C CG   . ASN B 1 181 ? -6.021  -30.103 -47.883 1.00 34.14  ? 168 ASN B CG   1 
ATOM   3067 O OD1  . ASN B 1 181 ? -5.962  -29.915 -46.663 1.00 32.05  ? 168 ASN B OD1  1 
ATOM   3068 N ND2  . ASN B 1 181 ? -4.974  -30.002 -48.709 1.00 30.51  ? 168 ASN B ND2  1 
ATOM   3069 N N    . GLY B 1 182 ? -8.217  -27.810 -49.810 1.00 24.00  ? 169 GLY B N    1 
ATOM   3070 C CA   . GLY B 1 182 ? -7.944  -26.448 -50.244 1.00 26.97  ? 169 GLY B CA   1 
ATOM   3071 C C    . GLY B 1 182 ? -9.067  -25.489 -49.875 1.00 31.23  ? 169 GLY B C    1 
ATOM   3072 O O    . GLY B 1 182 ? -8.795  -24.365 -49.458 1.00 30.31  ? 169 GLY B O    1 
ATOM   3073 N N    . MET B 1 183 ? -10.329 -25.922 -50.061 1.00 27.33  ? 170 MET B N    1 
ATOM   3074 C CA   . MET B 1 183 ? -11.452 -25.036 -49.804 1.00 29.99  ? 170 MET B CA   1 
ATOM   3075 C C    . MET B 1 183 ? -11.448 -24.567 -48.339 1.00 26.75  ? 170 MET B C    1 
ATOM   3076 O O    . MET B 1 183 ? -11.701 -23.402 -48.026 1.00 29.82  ? 170 MET B O    1 
ATOM   3077 C CB   . MET B 1 183 ? -12.763 -25.731 -50.221 1.00 31.30  ? 170 MET B CB   1 
ATOM   3078 C CG   . MET B 1 183 ? -14.015 -24.847 -50.194 1.00 41.68  ? 170 MET B CG   1 
ATOM   3079 S SD   . MET B 1 183 ? -15.540 -25.786 -50.490 1.00 43.71  ? 170 MET B SD   1 
ATOM   3080 C CE   . MET B 1 183 ? -15.902 -26.459 -48.873 1.00 42.08  ? 170 MET B CE   1 
ATOM   3081 N N    . THR B 1 184 ? -11.091 -25.462 -47.423 1.00 25.21  ? 171 THR B N    1 
ATOM   3082 C CA   . THR B 1 184 ? -10.890 -25.066 -46.034 1.00 25.95  ? 171 THR B CA   1 
ATOM   3083 C C    . THR B 1 184 ? -9.961  -23.841 -45.892 1.00 27.03  ? 171 THR B C    1 
ATOM   3084 O O    . THR B 1 184 ? -10.293 -22.903 -45.155 1.00 28.85  ? 171 THR B O    1 
ATOM   3085 C CB   . THR B 1 184 ? -10.408 -26.251 -45.217 1.00 25.84  ? 171 THR B CB   1 
ATOM   3086 O OG1  . THR B 1 184 ? -11.425 -27.253 -45.272 1.00 28.54  ? 171 THR B OG1  1 
ATOM   3087 C CG2  . THR B 1 184 ? -10.146 -25.848 -43.777 1.00 28.53  ? 171 THR B CG2  1 
ATOM   3088 N N    . ARG B 1 185 ? -8.777  -23.872 -46.533 1.00 24.43  ? 172 ARG B N    1 
ATOM   3089 C CA   . ARG B 1 185 ? -7.790  -22.800 -46.364 1.00 23.36  ? 172 ARG B CA   1 
ATOM   3090 C C    . ARG B 1 185 ? -8.311  -21.473 -46.913 1.00 23.60  ? 172 ARG B C    1 
ATOM   3091 O O    . ARG B 1 185 ? -8.141  -20.438 -46.246 1.00 25.11  ? 172 ARG B O    1 
ATOM   3092 C CB   . ARG B 1 185 ? -6.422  -23.170 -46.948 1.00 27.50  ? 172 ARG B CB   1 
ATOM   3093 C CG   . ARG B 1 185 ? -5.904  -24.432 -46.263 1.00 26.38  ? 172 ARG B CG   1 
ATOM   3094 C CD   . ARG B 1 185 ? -4.839  -25.229 -46.968 1.00 30.54  ? 172 ARG B CD   1 
ATOM   3095 N NE   . ARG B 1 185 ? -3.578  -24.501 -46.857 1.00 32.22  ? 172 ARG B NE   1 
ATOM   3096 C CZ   . ARG B 1 185 ? -2.574  -24.807 -46.045 1.00 37.72  ? 172 ARG B CZ   1 
ATOM   3097 N NH1  . ARG B 1 185 ? -1.541  -23.995 -45.995 1.00 35.14  ? 172 ARG B NH1  1 
ATOM   3098 N NH2  . ARG B 1 185 ? -2.596  -25.882 -45.264 1.00 35.45  ? 172 ARG B NH2  1 
ATOM   3099 N N    . THR B 1 186 ? -8.918  -21.491 -48.115 1.00 23.20  ? 173 THR B N    1 
ATOM   3100 C CA   . THR B 1 186 ? -9.334  -20.238 -48.747 1.00 27.33  ? 173 THR B CA   1 
ATOM   3101 C C    . THR B 1 186 ? -10.596 -19.699 -48.065 1.00 27.10  ? 173 THR B C    1 
ATOM   3102 O O    . THR B 1 186 ? -10.731 -18.496 -47.867 1.00 22.37  ? 173 THR B O    1 
ATOM   3103 C CB   . THR B 1 186 ? -9.514  -20.336 -50.275 1.00 27.48  ? 173 THR B CB   1 
ATOM   3104 O OG1  . THR B 1 186 ? -10.585 -21.240 -50.559 1.00 31.55  ? 173 THR B OG1  1 
ATOM   3105 C CG2  . THR B 1 186 ? -8.259  -20.814 -50.997 1.00 25.05  ? 173 THR B CG2  1 
ATOM   3106 N N    . LEU B 1 187 ? -11.525 -20.597 -47.689 1.00 29.24  ? 174 LEU B N    1 
ATOM   3107 C CA   . LEU B 1 187 ? -12.700 -20.168 -46.944 1.00 32.31  ? 174 LEU B CA   1 
ATOM   3108 C C    . LEU B 1 187 ? -12.303 -19.540 -45.615 1.00 30.39  ? 174 LEU B C    1 
ATOM   3109 O O    . LEU B 1 187 ? -12.930 -18.560 -45.199 1.00 31.77  ? 174 LEU B O    1 
ATOM   3110 C CB   . LEU B 1 187 ? -13.714 -21.292 -46.723 1.00 36.24  ? 174 LEU B CB   1 
ATOM   3111 C CG   . LEU B 1 187 ? -14.461 -21.747 -47.979 1.00 39.72  ? 174 LEU B CG   1 
ATOM   3112 C CD1  . LEU B 1 187 ? -15.692 -22.555 -47.638 1.00 40.48  ? 174 LEU B CD1  1 
ATOM   3113 C CD2  . LEU B 1 187 ? -14.831 -20.566 -48.793 1.00 39.29  ? 174 LEU B CD2  1 
ATOM   3114 N N    . ALA B 1 188 ? -11.281 -20.122 -44.955 1.00 27.26  ? 175 ALA B N    1 
ATOM   3115 C CA   . ALA B 1 188 ? -10.827 -19.586 -43.681 1.00 25.16  ? 175 ALA B CA   1 
ATOM   3116 C C    . ALA B 1 188 ? -10.405 -18.131 -43.871 1.00 25.86  ? 175 ALA B C    1 
ATOM   3117 O O    . ALA B 1 188 ? -10.644 -17.286 -43.010 1.00 29.05  ? 175 ALA B O    1 
ATOM   3118 C CB   . ALA B 1 188 ? -9.685  -20.428 -43.117 1.00 22.28  ? 175 ALA B CB   1 
ATOM   3119 N N    . ARG B 1 189 ? -9.756  -17.840 -44.996 1.00 25.49  ? 176 ARG B N    1 
ATOM   3120 C CA   . ARG B 1 189 ? -9.309  -16.477 -45.231 1.00 28.38  ? 176 ARG B CA   1 
ATOM   3121 C C    . ARG B 1 189 ? -10.505 -15.619 -45.632 1.00 32.40  ? 176 ARG B C    1 
ATOM   3122 O O    . ARG B 1 189 ? -10.706 -14.554 -45.068 1.00 31.90  ? 176 ARG B O    1 
ATOM   3123 C CB   . ARG B 1 189 ? -8.225  -16.433 -46.308 1.00 25.71  ? 176 ARG B CB   1 
ATOM   3124 C CG   . ARG B 1 189 ? -7.803  -15.042 -46.782 1.00 31.58  ? 176 ARG B CG   1 
ATOM   3125 C CD   . ARG B 1 189 ? -7.046  -14.202 -45.766 1.00 32.28  ? 176 ARG B CD   1 
ATOM   3126 N NE   . ARG B 1 189 ? -5.770  -14.797 -45.330 1.00 32.60  ? 176 ARG B NE   1 
ATOM   3127 C CZ   . ARG B 1 189 ? -5.067  -14.419 -44.264 1.00 36.09  ? 176 ARG B CZ   1 
ATOM   3128 N NH1  . ARG B 1 189 ? -5.483  -13.394 -43.554 1.00 28.45  ? 176 ARG B NH1  1 
ATOM   3129 N NH2  . ARG B 1 189 ? -3.944  -15.044 -43.917 1.00 33.14  ? 176 ARG B NH2  1 
ATOM   3130 N N    . GLU B 1 190 ? -11.312 -16.127 -46.568 1.00 29.54  ? 177 GLU B N    1 
ATOM   3131 C CA   . GLU B 1 190 ? -12.452 -15.377 -47.085 1.00 31.90  ? 177 GLU B CA   1 
ATOM   3132 C C    . GLU B 1 190 ? -13.381 -14.960 -45.948 1.00 33.79  ? 177 GLU B C    1 
ATOM   3133 O O    . GLU B 1 190 ? -13.909 -13.859 -45.972 1.00 34.04  ? 177 GLU B O    1 
ATOM   3134 C CB   . GLU B 1 190 ? -13.388 -16.289 -47.861 1.00 32.99  ? 177 GLU B CB   1 
ATOM   3135 C CG   . GLU B 1 190 ? -12.790 -16.812 -49.158 1.00 40.27  ? 177 GLU B CG   1 
ATOM   3136 C CD   . GLU B 1 190 ? -13.171 -15.944 -50.345 1.00 42.47  ? 177 GLU B CD   1 
ATOM   3137 O OE1  . GLU B 1 190 ? -13.610 -14.773 -50.162 1.00 41.76  ? 177 GLU B OE1  1 
ATOM   3138 O OE2  . GLU B 1 190 ? -13.076 -16.495 -51.452 1.00 32.60  ? 177 GLU B OE2  1 
ATOM   3139 N N    . LEU B 1 191 ? -13.571 -15.831 -44.938 1.00 35.93  ? 178 LEU B N    1 
ATOM   3140 C CA   . LEU B 1 191 ? -14.664 -15.617 -43.992 1.00 35.74  ? 178 LEU B CA   1 
ATOM   3141 C C    . LEU B 1 191 ? -14.151 -15.246 -42.601 1.00 36.28  ? 178 LEU B C    1 
ATOM   3142 O O    . LEU B 1 191 ? -14.937 -14.831 -41.744 1.00 30.38  ? 178 LEU B O    1 
ATOM   3143 C CB   . LEU B 1 191 ? -15.635 -16.795 -43.903 1.00 34.80  ? 178 LEU B CB   1 
ATOM   3144 C CG   . LEU B 1 191 ? -16.305 -17.244 -45.203 1.00 37.67  ? 178 LEU B CG   1 
ATOM   3145 C CD1  . LEU B 1 191 ? -17.082 -18.549 -44.994 1.00 30.46  ? 178 LEU B CD1  1 
ATOM   3146 C CD2  . LEU B 1 191 ? -17.194 -16.164 -45.812 1.00 30.96  ? 178 LEU B CD2  1 
ATOM   3147 N N    . GLY B 1 192 ? -12.838 -15.425 -42.367 1.00 33.98  ? 179 GLY B N    1 
ATOM   3148 C CA   . GLY B 1 192 ? -12.267 -15.180 -41.049 1.00 33.68  ? 179 GLY B CA   1 
ATOM   3149 C C    . GLY B 1 192 ? -12.570 -13.775 -40.534 1.00 36.25  ? 179 GLY B C    1 
ATOM   3150 O O    . GLY B 1 192 ? -12.823 -13.602 -39.348 1.00 33.04  ? 179 GLY B O    1 
ATOM   3151 N N    . GLY B 1 193 ? -12.558 -12.780 -41.426 1.00 37.59  ? 180 GLY B N    1 
ATOM   3152 C CA   . GLY B 1 193 ? -12.778 -11.403 -41.000 1.00 34.15  ? 180 GLY B CA   1 
ATOM   3153 C C    . GLY B 1 193 ? -14.181 -11.220 -40.432 1.00 39.77  ? 180 GLY B C    1 
ATOM   3154 O O    . GLY B 1 193 ? -14.427 -10.261 -39.708 1.00 42.36  ? 180 GLY B O    1 
ATOM   3155 N N    . GLN B 1 194 ? -15.077 -12.182 -40.716 1.00 41.57  ? 181 GLN B N    1 
ATOM   3156 C CA   . GLN B 1 194 ? -16.459 -12.161 -40.248 1.00 42.03  ? 181 GLN B CA   1 
ATOM   3157 C C    . GLN B 1 194 ? -16.649 -12.952 -38.949 1.00 40.45  ? 181 GLN B C    1 
ATOM   3158 O O    . GLN B 1 194 ? -17.777 -13.070 -38.476 1.00 33.57  ? 181 GLN B O    1 
ATOM   3159 C CB   . GLN B 1 194 ? -17.374 -12.747 -41.327 1.00 35.56  ? 181 GLN B CB   1 
ATOM   3160 C CG   . GLN B 1 194 ? -17.596 -11.849 -42.545 1.00 46.95  ? 181 GLN B CG   1 
ATOM   3161 C CD   . GLN B 1 194 ? -16.634 -10.678 -42.624 1.00 57.36  ? 181 GLN B CD   1 
ATOM   3162 O OE1  . GLN B 1 194 ? -16.674 -9.771  -41.781 1.00 69.08  ? 181 GLN B OE1  1 
ATOM   3163 N NE2  . GLN B 1 194 ? -15.767 -10.666 -43.631 1.00 49.77  ? 181 GLN B NE2  1 
ATOM   3164 N N    . GLY B 1 195 ? -15.567 -13.510 -38.385 1.00 36.31  ? 182 GLY B N    1 
ATOM   3165 C CA   . GLY B 1 195 ? -15.675 -14.276 -37.150 1.00 30.01  ? 182 GLY B CA   1 
ATOM   3166 C C    . GLY B 1 195 ? -15.855 -15.774 -37.397 1.00 33.82  ? 182 GLY B C    1 
ATOM   3167 O O    . GLY B 1 195 ? -16.061 -16.530 -36.458 1.00 31.29  ? 182 GLY B O    1 
ATOM   3168 N N    . ILE B 1 196 ? -15.835 -16.207 -38.660 1.00 31.64  ? 183 ILE B N    1 
ATOM   3169 C CA   . ILE B 1 196 ? -16.144 -17.599 -38.967 1.00 30.25  ? 183 ILE B CA   1 
ATOM   3170 C C    . ILE B 1 196 ? -14.810 -18.331 -39.110 1.00 29.71  ? 183 ILE B C    1 
ATOM   3171 O O    . ILE B 1 196 ? -13.922 -17.862 -39.817 1.00 30.34  ? 183 ILE B O    1 
ATOM   3172 C CB   . ILE B 1 196 ? -16.991 -17.735 -40.253 1.00 30.32  ? 183 ILE B CB   1 
ATOM   3173 C CG1  . ILE B 1 196 ? -18.269 -16.905 -40.177 1.00 26.34  ? 183 ILE B CG1  1 
ATOM   3174 C CG2  . ILE B 1 196 ? -17.292 -19.211 -40.573 1.00 30.15  ? 183 ILE B CG2  1 
ATOM   3175 C CD1  . ILE B 1 196 ? -18.922 -16.663 -41.547 1.00 29.93  ? 183 ILE B CD1  1 
ATOM   3176 N N    . ARG B 1 197 ? -14.695 -19.456 -38.400 1.00 30.40  ? 184 ARG B N    1 
ATOM   3177 C CA   . ARG B 1 197 ? -13.535 -20.320 -38.502 1.00 29.59  ? 184 ARG B CA   1 
ATOM   3178 C C    . ARG B 1 197 ? -13.949 -21.570 -39.265 1.00 29.94  ? 184 ARG B C    1 
ATOM   3179 O O    . ARG B 1 197 ? -15.079 -22.051 -39.169 1.00 32.09  ? 184 ARG B O    1 
ATOM   3180 C CB   . ARG B 1 197 ? -12.978 -20.821 -37.158 1.00 32.98  ? 184 ARG B CB   1 
ATOM   3181 C CG   . ARG B 1 197 ? -13.489 -20.168 -35.881 1.00 34.79  ? 184 ARG B CG   1 
ATOM   3182 C CD   . ARG B 1 197 ? -13.017 -20.764 -34.561 1.00 37.03  ? 184 ARG B CD   1 
ATOM   3183 N NE   . ARG B 1 197 ? -13.297 -22.157 -34.190 1.00 39.18  ? 184 ARG B NE   1 
ATOM   3184 C CZ   . ARG B 1 197 ? -14.334 -22.466 -33.411 1.00 38.66  ? 184 ARG B CZ   1 
ATOM   3185 N NH1  . ARG B 1 197 ? -15.266 -21.555 -33.204 1.00 37.67  ? 184 ARG B NH1  1 
ATOM   3186 N NH2  . ARG B 1 197 ? -14.447 -23.678 -32.879 1.00 42.42  ? 184 ARG B NH2  1 
ATOM   3187 N N    . ILE B 1 198 ? -12.999 -22.098 -40.030 1.00 29.55  ? 185 ILE B N    1 
ATOM   3188 C CA   . ILE B 1 198 ? -13.262 -23.224 -40.888 1.00 29.70  ? 185 ILE B CA   1 
ATOM   3189 C C    . ILE B 1 198 ? -12.054 -24.143 -40.777 1.00 23.21  ? 185 ILE B C    1 
ATOM   3190 O O    . ILE B 1 198 ? -10.921 -23.708 -41.008 1.00 23.86  ? 185 ILE B O    1 
ATOM   3191 C CB   . ILE B 1 198 ? -13.498 -22.756 -42.341 1.00 32.70  ? 185 ILE B CB   1 
ATOM   3192 C CG1  . ILE B 1 198 ? -14.661 -21.721 -42.465 1.00 40.11  ? 185 ILE B CG1  1 
ATOM   3193 C CG2  . ILE B 1 198 ? -13.775 -23.987 -43.214 1.00 34.33  ? 185 ILE B CG2  1 
ATOM   3194 C CD1  . ILE B 1 198 ? -14.232 -20.258 -42.558 1.00 36.08  ? 185 ILE B CD1  1 
ATOM   3195 N N    . ASN B 1 199 ? -12.298 -25.410 -40.435 1.00 22.30  ? 186 ASN B N    1 
ATOM   3196 C CA   . ASN B 1 199 ? -11.212 -26.369 -40.365 1.00 23.90  ? 186 ASN B CA   1 
ATOM   3197 C C    . ASN B 1 199 ? -11.673 -27.670 -40.998 1.00 26.58  ? 186 ASN B C    1 
ATOM   3198 O O    . ASN B 1 199 ? -12.846 -27.816 -41.333 1.00 31.13  ? 186 ASN B O    1 
ATOM   3199 C CB   . ASN B 1 199 ? -10.802 -26.633 -38.918 1.00 28.77  ? 186 ASN B CB   1 
ATOM   3200 C CG   . ASN B 1 199 ? -10.258 -25.405 -38.219 1.00 29.45  ? 186 ASN B CG   1 
ATOM   3201 O OD1  . ASN B 1 199 ? -9.146  -24.958 -38.535 1.00 28.28  ? 186 ASN B OD1  1 
ATOM   3202 N ND2  . ASN B 1 199 ? -11.034 -24.849 -37.288 1.00 22.57  ? 186 ASN B ND2  1 
ATOM   3203 N N    . SER B 1 200 ? -10.754 -28.615 -41.161 1.00 25.92  ? 187 SER B N    1 
ATOM   3204 C CA   . SER B 1 200 ? -11.137 -29.885 -41.739 1.00 26.99  ? 187 SER B CA   1 
ATOM   3205 C C    . SER B 1 200 ? -10.873 -30.988 -40.714 1.00 25.85  ? 187 SER B C    1 
ATOM   3206 O O    . SER B 1 200 ? -9.774  -31.052 -40.158 1.00 28.67  ? 187 SER B O    1 
ATOM   3207 C CB   . SER B 1 200 ? -10.400 -30.132 -43.065 1.00 29.66  ? 187 SER B CB   1 
ATOM   3208 O OG   . SER B 1 200 ? -10.742 -31.403 -43.626 1.00 44.25  ? 187 SER B OG   1 
ATOM   3209 N N    . LEU B 1 201 ? -11.879 -31.844 -40.489 1.00 22.44  ? 188 LEU B N    1 
ATOM   3210 C CA   . LEU B 1 201 ? -11.707 -33.001 -39.632 1.00 24.23  ? 188 LEU B CA   1 
ATOM   3211 C C    . LEU B 1 201 ? -11.364 -34.163 -40.563 1.00 25.39  ? 188 LEU B C    1 
ATOM   3212 O O    . LEU B 1 201 ? -12.095 -34.412 -41.503 1.00 30.81  ? 188 LEU B O    1 
ATOM   3213 C CB   . LEU B 1 201 ? -13.014 -33.184 -38.851 1.00 23.21  ? 188 LEU B CB   1 
ATOM   3214 C CG   . LEU B 1 201 ? -13.090 -34.294 -37.783 1.00 26.94  ? 188 LEU B CG   1 
ATOM   3215 C CD1  . LEU B 1 201 ? -14.423 -34.246 -37.050 1.00 30.83  ? 188 LEU B CD1  1 
ATOM   3216 C CD2  . LEU B 1 201 ? -12.894 -35.720 -38.314 1.00 25.89  ? 188 LEU B CD2  1 
ATOM   3217 N N    . VAL B 1 202 ? -10.243 -34.848 -40.311 1.00 27.04  ? 189 VAL B N    1 
ATOM   3218 C CA   . VAL B 1 202 ? -9.672  -35.767 -41.278 1.00 26.45  ? 189 VAL B CA   1 
ATOM   3219 C C    . VAL B 1 202 ? -9.548  -37.152 -40.635 1.00 27.12  ? 189 VAL B C    1 
ATOM   3220 O O    . VAL B 1 202 ? -8.570  -37.470 -39.960 1.00 29.49  ? 189 VAL B O    1 
ATOM   3221 C CB   . VAL B 1 202 ? -8.310  -35.243 -41.779 1.00 27.13  ? 189 VAL B CB   1 
ATOM   3222 C CG1  . VAL B 1 202 ? -7.713  -36.125 -42.875 1.00 25.85  ? 189 VAL B CG1  1 
ATOM   3223 C CG2  . VAL B 1 202 ? -8.347  -33.778 -42.229 1.00 26.88  ? 189 VAL B CG2  1 
ATOM   3224 N N    . PRO B 1 203 ? -10.537 -38.049 -40.797 1.00 27.07  ? 190 PRO B N    1 
ATOM   3225 C CA   . PRO B 1 203 ? -10.432 -39.356 -40.161 1.00 27.64  ? 190 PRO B CA   1 
ATOM   3226 C C    . PRO B 1 203 ? -9.555  -40.322 -40.939 1.00 25.30  ? 190 PRO B C    1 
ATOM   3227 O O    . PRO B 1 203 ? -9.412  -40.202 -42.137 1.00 30.98  ? 190 PRO B O    1 
ATOM   3228 C CB   . PRO B 1 203 ? -11.874 -39.854 -40.147 1.00 30.79  ? 190 PRO B CB   1 
ATOM   3229 C CG   . PRO B 1 203 ? -12.715 -38.782 -40.813 1.00 28.41  ? 190 PRO B CG   1 
ATOM   3230 C CD   . PRO B 1 203 ? -11.815 -37.800 -41.475 1.00 28.74  ? 190 PRO B CD   1 
ATOM   3231 N N    . GLY B 1 204 ? -9.102  -41.354 -40.247 1.00 29.61  ? 191 GLY B N    1 
ATOM   3232 C CA   . GLY B 1 204 ? -8.433  -42.492 -40.816 1.00 32.01  ? 191 GLY B CA   1 
ATOM   3233 C C    . GLY B 1 204 ? -9.503  -43.521 -41.114 1.00 32.34  ? 191 GLY B C    1 
ATOM   3234 O O    . GLY B 1 204 ? -10.583 -43.134 -41.541 1.00 28.46  ? 191 GLY B O    1 
ATOM   3235 N N    . ALA B 1 205 ? -9.180  -44.801 -40.872 1.00 36.63  ? 192 ALA B N    1 
ATOM   3236 C CA   . ALA B 1 205 ? -10.095 -45.902 -41.181 1.00 36.54  ? 192 ALA B CA   1 
ATOM   3237 C C    . ALA B 1 205 ? -11.008 -46.149 -39.988 1.00 35.51  ? 192 ALA B C    1 
ATOM   3238 O O    . ALA B 1 205 ? -10.617 -46.755 -38.998 1.00 39.86  ? 192 ALA B O    1 
ATOM   3239 C CB   . ALA B 1 205 ? -9.312  -47.160 -41.543 1.00 42.56  ? 192 ALA B CB   1 
ATOM   3240 N N    . ILE B 1 206 ? -12.220 -45.646 -40.099 1.00 33.24  ? 193 ILE B N    1 
ATOM   3241 C CA   . ILE B 1 206 ? -13.211 -45.656 -39.047 1.00 38.51  ? 193 ILE B CA   1 
ATOM   3242 C C    . ILE B 1 206 ? -14.107 -46.889 -39.238 1.00 40.48  ? 193 ILE B C    1 
ATOM   3243 O O    . ILE B 1 206 ? -14.649 -47.101 -40.326 1.00 36.56  ? 193 ILE B O    1 
ATOM   3244 C CB   . ILE B 1 206 ? -14.022 -44.359 -39.145 1.00 30.10  ? 193 ILE B CB   1 
ATOM   3245 C CG1  . ILE B 1 206 ? -13.118 -43.124 -39.242 1.00 32.89  ? 193 ILE B CG1  1 
ATOM   3246 C CG2  . ILE B 1 206 ? -14.995 -44.259 -37.968 1.00 30.46  ? 193 ILE B CG2  1 
ATOM   3247 C CD1  . ILE B 1 206 ? -12.188 -42.956 -38.045 1.00 28.82  ? 193 ILE B CD1  1 
ATOM   3248 N N    . ARG B 1 207 ? -14.203 -47.724 -38.192 1.00 43.10  ? 194 ARG B N    1 
ATOM   3249 C CA   . ARG B 1 207 ? -15.114 -48.867 -38.182 1.00 45.19  ? 194 ARG B CA   1 
ATOM   3250 C C    . ARG B 1 207 ? -16.525 -48.303 -38.080 1.00 52.34  ? 194 ARG B C    1 
ATOM   3251 O O    . ARG B 1 207 ? -16.782 -47.525 -37.168 1.00 50.41  ? 194 ARG B O    1 
ATOM   3252 C CB   . ARG B 1 207 ? -14.809 -49.752 -36.959 1.00 48.09  ? 194 ARG B CB   1 
ATOM   3253 C CG   . ARG B 1 207 ? -15.458 -51.114 -36.735 1.00 50.38  ? 194 ARG B CG   1 
ATOM   3254 C CD   . ARG B 1 207 ? -15.132 -51.743 -35.378 1.00 43.87  ? 194 ARG B CD   1 
ATOM   3255 N N    . THR B 1 208 ? -17.397 -48.632 -39.049 1.00 63.32  ? 195 THR B N    1 
ATOM   3256 C CA   . THR B 1 208 ? -18.821 -48.317 -38.963 1.00 75.71  ? 195 THR B CA   1 
ATOM   3257 C C    . THR B 1 208 ? -19.616 -49.529 -39.449 1.00 89.10  ? 195 THR B C    1 
ATOM   3258 O O    . THR B 1 208 ? -19.036 -50.510 -39.907 1.00 90.77  ? 195 THR B O    1 
ATOM   3259 C CB   . THR B 1 208 ? -19.224 -47.059 -39.744 1.00 68.11  ? 195 THR B CB   1 
ATOM   3260 O OG1  . THR B 1 208 ? -19.239 -47.476 -41.105 1.00 73.17  ? 195 THR B OG1  1 
ATOM   3261 C CG2  . THR B 1 208 ? -18.328 -45.854 -39.513 1.00 67.04  ? 195 THR B CG2  1 
ATOM   3262 N N    . GLU B 1 209 ? -20.949 -49.425 -39.357 1.00 96.95  ? 196 GLU B N    1 
ATOM   3263 C CA   . GLU B 1 209 ? -21.886 -50.447 -39.804 1.00 94.68  ? 196 GLU B CA   1 
ATOM   3264 C C    . GLU B 1 209 ? -21.782 -50.646 -41.318 1.00 89.67  ? 196 GLU B C    1 
ATOM   3265 O O    . GLU B 1 209 ? -21.726 -51.784 -41.785 1.00 81.63  ? 196 GLU B O    1 
ATOM   3266 C CB   . GLU B 1 209 ? -23.302 -50.081 -39.347 1.00 86.78  ? 196 GLU B CB   1 
ATOM   3267 N N    . ARG B 1 210 ? -21.733 -49.526 -42.060 1.00 88.46  ? 197 ARG B N    1 
ATOM   3268 C CA   . ARG B 1 210 ? -21.689 -49.489 -43.514 1.00 88.82  ? 197 ARG B CA   1 
ATOM   3269 C C    . ARG B 1 210 ? -20.400 -50.112 -44.054 1.00 97.46  ? 197 ARG B C    1 
ATOM   3270 O O    . ARG B 1 210 ? -20.461 -50.845 -45.041 1.00 100.47 ? 197 ARG B O    1 
ATOM   3271 C CB   . ARG B 1 210 ? -21.930 -48.075 -44.054 1.00 75.37  ? 197 ARG B CB   1 
ATOM   3272 N N    . GLN B 1 211 ? -19.246 -49.844 -43.417 1.00 98.73  ? 198 GLN B N    1 
ATOM   3273 C CA   . GLN B 1 211 ? -18.012 -50.514 -43.820 1.00 102.86 ? 198 GLN B CA   1 
ATOM   3274 C C    . GLN B 1 211 ? -18.178 -52.030 -43.669 1.00 118.22 ? 198 GLN B C    1 
ATOM   3275 O O    . GLN B 1 211 ? -18.717 -52.504 -42.671 1.00 120.81 ? 198 GLN B O    1 
ATOM   3276 C CB   . GLN B 1 211 ? -16.741 -49.956 -43.176 1.00 86.95  ? 198 GLN B CB   1 
ATOM   3277 N N    . ASP B 1 212 ? -17.717 -52.775 -44.686 1.00 124.04 ? 199 ASP B N    1 
ATOM   3278 C CA   . ASP B 1 212 ? -18.001 -54.196 -44.861 1.00 116.87 ? 199 ASP B CA   1 
ATOM   3279 C C    . ASP B 1 212 ? -19.485 -54.482 -44.584 1.00 117.73 ? 199 ASP B C    1 
ATOM   3280 O O    . ASP B 1 212 ? -20.210 -54.781 -45.558 1.00 110.27 ? 199 ASP B O    1 
ATOM   3281 C CB   . ASP B 1 212 ? -17.045 -55.085 -44.077 1.00 104.32 ? 199 ASP B CB   1 
ATOM   3282 N N    . GLY B 1 221 ? -13.188 -62.188 -43.196 1.00 55.13  ? 208 GLY B N    1 
ATOM   3283 C CA   . GLY B 1 221 ? -12.414 -61.366 -44.146 1.00 62.80  ? 208 GLY B CA   1 
ATOM   3284 C C    . GLY B 1 221 ? -12.529 -59.889 -43.777 1.00 62.53  ? 208 GLY B C    1 
ATOM   3285 O O    . GLY B 1 221 ? -11.690 -59.067 -44.139 1.00 64.75  ? 208 GLY B O    1 
ATOM   3286 N N    . LEU B 1 222 ? -13.613 -59.570 -43.068 1.00 60.71  ? 209 LEU B N    1 
ATOM   3287 C CA   . LEU B 1 222 ? -13.750 -58.312 -42.359 1.00 56.61  ? 209 LEU B CA   1 
ATOM   3288 C C    . LEU B 1 222 ? -12.683 -58.285 -41.261 1.00 60.27  ? 209 LEU B C    1 
ATOM   3289 O O    . LEU B 1 222 ? -11.908 -57.336 -41.159 1.00 59.35  ? 209 LEU B O    1 
ATOM   3290 C CB   . LEU B 1 222 ? -15.183 -58.221 -41.830 1.00 46.90  ? 209 LEU B CB   1 
ATOM   3291 N N    . GLU B 1 223 ? -12.597 -59.373 -40.485 1.00 57.62  ? 210 GLU B N    1 
ATOM   3292 C CA   . GLU B 1 223 ? -11.634 -59.478 -39.400 1.00 55.86  ? 210 GLU B CA   1 
ATOM   3293 C C    . GLU B 1 223 ? -10.221 -59.265 -39.940 1.00 46.58  ? 210 GLU B C    1 
ATOM   3294 O O    . GLU B 1 223 ? -9.393  -58.600 -39.315 1.00 43.12  ? 210 GLU B O    1 
ATOM   3295 C CB   . GLU B 1 223 ? -11.828 -60.784 -38.621 1.00 54.52  ? 210 GLU B CB   1 
ATOM   3296 C CG   . GLU B 1 223 ? -10.946 -60.898 -37.378 1.00 61.81  ? 210 GLU B CG   1 
ATOM   3297 C CD   . GLU B 1 223 ? -10.757 -59.623 -36.554 1.00 68.86  ? 210 GLU B CD   1 
ATOM   3298 O OE1  . GLU B 1 223 ? -11.765 -58.928 -36.307 1.00 75.34  ? 210 GLU B OE1  1 
ATOM   3299 O OE2  . GLU B 1 223 ? -9.611  -59.325 -36.138 1.00 58.06  ? 210 GLU B OE2  1 
ATOM   3300 N N    . ALA B 1 224 ? -9.946  -59.837 -41.115 1.00 49.00  ? 211 ALA B N    1 
ATOM   3301 C CA   . ALA B 1 224 ? -8.609  -59.802 -41.673 1.00 47.46  ? 211 ALA B CA   1 
ATOM   3302 C C    . ALA B 1 224 ? -8.236  -58.360 -42.026 1.00 47.14  ? 211 ALA B C    1 
ATOM   3303 O O    . ALA B 1 224 ? -7.135  -57.918 -41.731 1.00 46.25  ? 211 ALA B O    1 
ATOM   3304 C CB   . ALA B 1 224 ? -8.540  -60.704 -42.885 1.00 47.92  ? 211 ALA B CB   1 
ATOM   3305 N N    . ALA B 1 225 ? -9.174  -57.647 -42.662 1.00 52.67  ? 212 ALA B N    1 
ATOM   3306 C CA   . ALA B 1 225 ? -8.975  -56.288 -43.137 1.00 54.58  ? 212 ALA B CA   1 
ATOM   3307 C C    . ALA B 1 225 ? -8.839  -55.339 -41.943 1.00 51.91  ? 212 ALA B C    1 
ATOM   3308 O O    . ALA B 1 225 ? -8.027  -54.412 -41.963 1.00 47.56  ? 212 ALA B O    1 
ATOM   3309 C CB   . ALA B 1 225 ? -10.109 -55.912 -44.065 1.00 48.97  ? 212 ALA B CB   1 
ATOM   3310 N N    . SER B 1 226 ? -9.603  -55.626 -40.880 1.00 57.45  ? 213 SER B N    1 
ATOM   3311 C CA   . SER B 1 226 ? -9.509  -54.873 -39.639 1.00 55.33  ? 213 SER B CA   1 
ATOM   3312 C C    . SER B 1 226 ? -8.127  -55.034 -39.005 1.00 54.32  ? 213 SER B C    1 
ATOM   3313 O O    . SER B 1 226 ? -7.558  -54.050 -38.538 1.00 58.23  ? 213 SER B O    1 
ATOM   3314 C CB   . SER B 1 226 ? -10.631 -55.188 -38.699 1.00 54.38  ? 213 SER B CB   1 
ATOM   3315 O OG   . SER B 1 226 ? -10.536 -54.387 -37.526 1.00 50.64  ? 213 SER B OG   1 
ATOM   3316 N N    . GLN B 1 227 ? -7.573  -56.257 -39.035 1.00 51.60  ? 214 GLN B N    1 
ATOM   3317 C CA   . GLN B 1 227 ? -6.253  -56.500 -38.479 1.00 51.65  ? 214 GLN B CA   1 
ATOM   3318 C C    . GLN B 1 227 ? -5.181  -55.748 -39.261 1.00 55.69  ? 214 GLN B C    1 
ATOM   3319 O O    . GLN B 1 227 ? -4.218  -55.267 -38.663 1.00 59.20  ? 214 GLN B O    1 
ATOM   3320 C CB   . GLN B 1 227 ? -5.808  -57.959 -38.467 1.00 49.48  ? 214 GLN B CB   1 
ATOM   3321 C CG   . GLN B 1 227 ? -6.042  -58.661 -37.138 1.00 41.11  ? 214 GLN B CG   1 
ATOM   3322 C CD   . GLN B 1 227 ? -5.585  -57.880 -35.923 1.00 44.08  ? 214 GLN B CD   1 
ATOM   3323 O OE1  . GLN B 1 227 ? -4.458  -57.358 -35.817 1.00 45.03  ? 214 GLN B OE1  1 
ATOM   3324 N NE2  . GLN B 1 227 ? -6.491  -57.829 -34.963 1.00 38.54  ? 214 GLN B NE2  1 
ATOM   3325 N N    . ALA B 1 228 ? -5.345  -55.673 -40.592 1.00 51.10  ? 215 ALA B N    1 
ATOM   3326 C CA   . ALA B 1 228 ? -4.362  -55.021 -41.437 1.00 50.38  ? 215 ALA B CA   1 
ATOM   3327 C C    . ALA B 1 228 ? -4.302  -53.528 -41.108 1.00 44.42  ? 215 ALA B C    1 
ATOM   3328 O O    . ALA B 1 228 ? -3.206  -52.961 -41.081 1.00 51.19  ? 215 ALA B O    1 
ATOM   3329 C CB   . ALA B 1 228 ? -4.629  -55.310 -42.906 1.00 55.40  ? 215 ALA B CB   1 
ATOM   3330 N N    . PHE B 1 229 ? -5.459  -52.924 -40.778 1.00 38.83  ? 216 PHE B N    1 
ATOM   3331 C CA   . PHE B 1 229 ? -5.483  -51.535 -40.334 1.00 46.41  ? 216 PHE B CA   1 
ATOM   3332 C C    . PHE B 1 229 ? -4.720  -51.388 -39.014 1.00 49.57  ? 216 PHE B C    1 
ATOM   3333 O O    . PHE B 1 229 ? -3.963  -50.436 -38.840 1.00 45.90  ? 216 PHE B O    1 
ATOM   3334 C CB   . PHE B 1 229 ? -6.880  -50.944 -40.135 1.00 38.35  ? 216 PHE B CB   1 
ATOM   3335 C CG   . PHE B 1 229 ? -7.689  -50.701 -41.398 1.00 45.99  ? 216 PHE B CG   1 
ATOM   3336 C CD1  . PHE B 1 229 ? -7.161  -49.999 -42.483 1.00 44.26  ? 216 PHE B CD1  1 
ATOM   3337 C CD2  . PHE B 1 229 ? -9.000  -51.170 -41.492 1.00 48.04  ? 216 PHE B CD2  1 
ATOM   3338 C CE1  . PHE B 1 229 ? -7.939  -49.761 -43.620 1.00 40.93  ? 216 PHE B CE1  1 
ATOM   3339 C CE2  . PHE B 1 229 ? -9.773  -50.917 -42.626 1.00 44.50  ? 216 PHE B CE2  1 
ATOM   3340 C CZ   . PHE B 1 229 ? -9.235  -50.230 -43.694 1.00 40.42  ? 216 PHE B CZ   1 
ATOM   3341 N N    . ILE B 1 230 ? -4.905  -52.339 -38.081 1.00 45.63  ? 217 ILE B N    1 
ATOM   3342 C CA   . ILE B 1 230 ? -4.228  -52.263 -36.794 1.00 40.27  ? 217 ILE B CA   1 
ATOM   3343 C C    . ILE B 1 230 ? -2.729  -52.392 -37.021 1.00 40.68  ? 217 ILE B C    1 
ATOM   3344 O O    . ILE B 1 230 ? -1.931  -51.691 -36.396 1.00 44.62  ? 217 ILE B O    1 
ATOM   3345 C CB   . ILE B 1 230 ? -4.773  -53.298 -35.790 1.00 44.89  ? 217 ILE B CB   1 
ATOM   3346 C CG1  . ILE B 1 230 ? -6.197  -52.981 -35.349 1.00 42.60  ? 217 ILE B CG1  1 
ATOM   3347 C CG2  . ILE B 1 230 ? -3.839  -53.476 -34.590 1.00 49.95  ? 217 ILE B CG2  1 
ATOM   3348 C CD1  . ILE B 1 230 ? -6.863  -54.090 -34.535 1.00 50.59  ? 217 ILE B CD1  1 
ATOM   3349 N N    . ASP B 1 231 ? -2.335  -53.264 -37.946 1.00 44.46  ? 218 ASP B N    1 
ATOM   3350 C CA   . ASP B 1 231 ? -0.914  -53.498 -38.147 1.00 48.69  ? 218 ASP B CA   1 
ATOM   3351 C C    . ASP B 1 231 ? -0.291  -52.253 -38.784 1.00 40.67  ? 218 ASP B C    1 
ATOM   3352 O O    . ASP B 1 231 ? 0.870   -51.942 -38.541 1.00 38.39  ? 218 ASP B O    1 
ATOM   3353 C CB   . ASP B 1 231 ? -0.642  -54.786 -38.914 1.00 60.17  ? 218 ASP B CB   1 
ATOM   3354 C CG   . ASP B 1 231 ? -1.263  -56.066 -38.351 1.00 82.81  ? 218 ASP B CG   1 
ATOM   3355 O OD1  . ASP B 1 231 ? -1.756  -56.040 -37.195 1.00 91.35  ? 218 ASP B OD1  1 
ATOM   3356 O OD2  . ASP B 1 231 ? -1.276  -57.091 -39.076 1.00 85.48  ? 218 ASP B OD2  1 
ATOM   3357 N N    . GLN B 1 232 ? -1.079  -51.526 -39.572 1.00 36.58  ? 219 GLN B N    1 
ATOM   3358 C CA   . GLN B 1 232 ? -0.547  -50.392 -40.316 1.00 40.49  ? 219 GLN B CA   1 
ATOM   3359 C C    . GLN B 1 232 ? -0.504  -49.133 -39.450 1.00 39.21  ? 219 GLN B C    1 
ATOM   3360 O O    . GLN B 1 232 ? 0.367   -48.293 -39.645 1.00 41.63  ? 219 GLN B O    1 
ATOM   3361 C CB   . GLN B 1 232 ? -1.398  -50.104 -41.551 1.00 42.68  ? 219 GLN B CB   1 
ATOM   3362 C CG   . GLN B 1 232 ? -1.083  -51.009 -42.737 1.00 43.36  ? 219 GLN B CG   1 
ATOM   3363 C CD   . GLN B 1 232 ? -2.045  -50.805 -43.881 1.00 43.08  ? 219 GLN B CD   1 
ATOM   3364 O OE1  . GLN B 1 232 ? -2.066  -49.751 -44.523 1.00 43.99  ? 219 GLN B OE1  1 
ATOM   3365 N NE2  . GLN B 1 232 ? -2.867  -51.809 -44.145 1.00 48.68  ? 219 GLN B NE2  1 
ATOM   3366 N N    . GLN B 1 233 ? -1.466  -49.024 -38.528 1.00 40.03  ? 220 GLN B N    1 
ATOM   3367 C CA   . GLN B 1 233 ? -1.633  -47.907 -37.608 1.00 37.08  ? 220 GLN B CA   1 
ATOM   3368 C C    . GLN B 1 233 ? -0.505  -47.896 -36.590 1.00 37.61  ? 220 GLN B C    1 
ATOM   3369 O O    . GLN B 1 233 ? 0.110   -48.931 -36.359 1.00 38.15  ? 220 GLN B O    1 
ATOM   3370 C CB   . GLN B 1 233 ? -2.986  -47.942 -36.904 1.00 34.46  ? 220 GLN B CB   1 
ATOM   3371 C CG   . GLN B 1 233 ? -4.161  -47.625 -37.815 1.00 36.65  ? 220 GLN B CG   1 
ATOM   3372 C CD   . GLN B 1 233 ? -5.497  -47.798 -37.129 1.00 40.22  ? 220 GLN B CD   1 
ATOM   3373 O OE1  . GLN B 1 233 ? -5.554  -48.200 -35.964 1.00 50.60  ? 220 GLN B OE1  1 
ATOM   3374 N NE2  . GLN B 1 233 ? -6.587  -47.521 -37.835 1.00 36.65  ? 220 GLN B NE2  1 
ATOM   3375 N N    . MET B 1 234 ? -0.215  -46.706 -36.023 1.00 36.94  ? 221 MET B N    1 
ATOM   3376 C CA   . MET B 1 234 ? 0.742   -46.600 -34.924 1.00 30.87  ? 221 MET B CA   1 
ATOM   3377 C C    . MET B 1 234 ? 0.116   -47.051 -33.600 1.00 31.92  ? 221 MET B C    1 
ATOM   3378 O O    . MET B 1 234 ? 0.826   -47.627 -32.790 1.00 41.93  ? 221 MET B O    1 
ATOM   3379 C CB   . MET B 1 234 ? 1.291   -45.179 -34.753 1.00 29.83  ? 221 MET B CB   1 
ATOM   3380 C CG   . MET B 1 234 ? 2.025   -44.663 -35.950 1.00 32.26  ? 221 MET B CG   1 
ATOM   3381 S SD   . MET B 1 234 ? 2.250   -42.889 -35.664 1.00 38.28  ? 221 MET B SD   1 
ATOM   3382 C CE   . MET B 1 234 ? 3.094   -42.327 -37.137 1.00 39.51  ? 221 MET B CE   1 
ATOM   3383 N N    . LEU B 1 235 ? -1.152  -46.700 -33.336 1.00 34.94  ? 222 LEU B N    1 
ATOM   3384 C CA   . LEU B 1 235 ? -1.858  -47.139 -32.137 1.00 38.44  ? 222 LEU B CA   1 
ATOM   3385 C C    . LEU B 1 235 ? -2.638  -48.411 -32.476 1.00 40.97  ? 222 LEU B C    1 
ATOM   3386 O O    . LEU B 1 235 ? -3.357  -48.445 -33.472 1.00 36.60  ? 222 LEU B O    1 
ATOM   3387 C CB   . LEU B 1 235 ? -2.809  -46.054 -31.627 1.00 33.41  ? 222 LEU B CB   1 
ATOM   3388 C CG   . LEU B 1 235 ? -2.165  -44.728 -31.201 1.00 37.47  ? 222 LEU B CG   1 
ATOM   3389 C CD1  . LEU B 1 235 ? -3.254  -43.716 -30.906 1.00 29.67  ? 222 LEU B CD1  1 
ATOM   3390 C CD2  . LEU B 1 235 ? -1.203  -44.834 -30.005 1.00 32.22  ? 222 LEU B CD2  1 
ATOM   3391 N N    . LYS B 1 236 ? -2.512  -49.456 -31.656 1.00 43.67  ? 223 LYS B N    1 
ATOM   3392 C CA   . LYS B 1 236 ? -2.943  -50.769 -32.103 1.00 42.02  ? 223 LYS B CA   1 
ATOM   3393 C C    . LYS B 1 236 ? -4.381  -51.075 -31.685 1.00 45.72  ? 223 LYS B C    1 
ATOM   3394 O O    . LYS B 1 236 ? -4.630  -52.124 -31.106 1.00 49.02  ? 223 LYS B O    1 
ATOM   3395 C CB   . LYS B 1 236 ? -1.967  -51.848 -31.619 1.00 42.68  ? 223 LYS B CB   1 
ATOM   3396 C CG   . LYS B 1 236 ? -0.541  -51.634 -32.064 1.00 42.85  ? 223 LYS B CG   1 
ATOM   3397 C CD   . LYS B 1 236 ? -0.357  -51.666 -33.584 1.00 45.67  ? 223 LYS B CD   1 
ATOM   3398 C CE   . LYS B 1 236 ? 0.990   -51.131 -34.002 1.00 41.44  ? 223 LYS B CE   1 
ATOM   3399 N NZ   . LYS B 1 236 ? 1.176   -51.274 -35.440 1.00 42.64  ? 223 LYS B NZ   1 
ATOM   3400 N N    . PHE B 1 237 ? -5.332  -50.195 -32.017 1.00 43.79  ? 224 PHE B N    1 
ATOM   3401 C CA   . PHE B 1 237 ? -6.751  -50.466 -31.819 1.00 37.65  ? 224 PHE B CA   1 
ATOM   3402 C C    . PHE B 1 237 ? -7.520  -49.839 -32.983 1.00 40.75  ? 224 PHE B C    1 
ATOM   3403 O O    . PHE B 1 237 ? -6.985  -48.989 -33.697 1.00 41.19  ? 224 PHE B O    1 
ATOM   3404 C CB   . PHE B 1 237 ? -7.250  -49.969 -30.463 1.00 43.91  ? 224 PHE B CB   1 
ATOM   3405 C CG   . PHE B 1 237 ? -7.166  -48.460 -30.243 1.00 43.93  ? 224 PHE B CG   1 
ATOM   3406 C CD1  . PHE B 1 237 ? -8.202  -47.622 -30.659 1.00 40.66  ? 224 PHE B CD1  1 
ATOM   3407 C CD2  . PHE B 1 237 ? -6.067  -47.884 -29.607 1.00 42.32  ? 224 PHE B CD2  1 
ATOM   3408 C CE1  . PHE B 1 237 ? -8.148  -46.246 -30.433 1.00 38.99  ? 224 PHE B CE1  1 
ATOM   3409 C CE2  . PHE B 1 237 ? -6.012  -46.505 -29.397 1.00 46.64  ? 224 PHE B CE2  1 
ATOM   3410 C CZ   . PHE B 1 237 ? -7.057  -45.692 -29.785 1.00 35.16  ? 224 PHE B CZ   1 
ATOM   3411 N N    . ARG B 1 238 ? -8.755  -50.288 -33.214 1.00 33.90  ? 225 ARG B N    1 
ATOM   3412 C CA   . ARG B 1 238 ? -9.550  -49.752 -34.307 1.00 37.11  ? 225 ARG B CA   1 
ATOM   3413 C C    . ARG B 1 238 ? -10.222 -48.468 -33.837 1.00 39.30  ? 225 ARG B C    1 
ATOM   3414 O O    . ARG B 1 238 ? -10.674 -48.382 -32.698 1.00 33.71  ? 225 ARG B O    1 
ATOM   3415 C CB   . ARG B 1 238 ? -10.593 -50.768 -34.797 1.00 39.13  ? 225 ARG B CB   1 
ATOM   3416 C CG   . ARG B 1 238 ? -9.890  -51.630 -35.836 1.00 36.83  ? 225 ARG B CG   1 
ATOM   3417 C CD   . ARG B 1 238 ? -9.511  -50.825 -37.109 1.00 35.26  ? 225 ARG B CD   1 
ATOM   3418 N NE   . ARG B 1 238 ? -10.543 -51.320 -38.014 1.00 45.91  ? 225 ARG B NE   1 
ATOM   3419 C CZ   . ARG B 1 238 ? -11.460 -50.713 -38.718 1.00 51.63  ? 225 ARG B CZ   1 
ATOM   3420 N NH1  . ARG B 1 238 ? -11.391 -49.416 -38.978 1.00 43.90  ? 225 ARG B NH1  1 
ATOM   3421 N NH2  . ARG B 1 238 ? -12.443 -51.464 -39.184 1.00 46.95  ? 225 ARG B NH2  1 
ATOM   3422 N N    . LEU B 1 239 ? -10.244 -47.470 -34.722 1.00 39.03  ? 226 LEU B N    1 
ATOM   3423 C CA   . LEU B 1 239 ? -10.966 -46.236 -34.472 1.00 32.35  ? 226 LEU B CA   1 
ATOM   3424 C C    . LEU B 1 239 ? -12.424 -46.497 -34.810 1.00 41.92  ? 226 LEU B C    1 
ATOM   3425 O O    . LEU B 1 239 ? -12.721 -47.339 -35.665 1.00 46.41  ? 226 LEU B O    1 
ATOM   3426 C CB   . LEU B 1 239 ? -10.413 -45.079 -35.332 1.00 29.48  ? 226 LEU B CB   1 
ATOM   3427 C CG   . LEU B 1 239 ? -8.916  -44.760 -35.208 1.00 30.52  ? 226 LEU B CG   1 
ATOM   3428 C CD1  . LEU B 1 239 ? -8.473  -43.696 -36.213 1.00 31.91  ? 226 LEU B CD1  1 
ATOM   3429 C CD2  . LEU B 1 239 ? -8.612  -44.256 -33.795 1.00 37.80  ? 226 LEU B CD2  1 
ATOM   3430 N N    . ASP B 1 240 ? -13.326 -45.733 -34.177 1.00 41.24  ? 227 ASP B N    1 
ATOM   3431 C CA   . ASP B 1 240 ? -14.743 -45.815 -34.485 1.00 44.06  ? 227 ASP B CA   1 
ATOM   3432 C C    . ASP B 1 240 ? -15.303 -44.398 -34.575 1.00 41.80  ? 227 ASP B C    1 
ATOM   3433 O O    . ASP B 1 240 ? -14.562 -43.414 -34.507 1.00 41.09  ? 227 ASP B O    1 
ATOM   3434 C CB   . ASP B 1 240 ? -15.504 -46.690 -33.487 1.00 50.84  ? 227 ASP B CB   1 
ATOM   3435 C CG   . ASP B 1 240 ? -15.411 -46.270 -32.023 1.00 62.05  ? 227 ASP B CG   1 
ATOM   3436 O OD1  . ASP B 1 240 ? -15.499 -45.054 -31.731 1.00 63.53  ? 227 ASP B OD1  1 
ATOM   3437 O OD2  . ASP B 1 240 ? -15.291 -47.166 -31.169 1.00 75.19  ? 227 ASP B OD2  1 
ATOM   3438 N N    . ALA B 1 241 ? -16.627 -44.321 -34.745 1.00 37.06  ? 228 ALA B N    1 
ATOM   3439 C CA   . ALA B 1 241 ? -17.312 -43.067 -35.016 1.00 40.30  ? 228 ALA B CA   1 
ATOM   3440 C C    . ALA B 1 241 ? -17.154 -42.104 -33.846 1.00 42.09  ? 228 ALA B C    1 
ATOM   3441 O O    . ALA B 1 241 ? -17.181 -40.876 -34.048 1.00 41.50  ? 228 ALA B O    1 
ATOM   3442 C CB   . ALA B 1 241 ? -18.759 -43.317 -35.369 1.00 37.40  ? 228 ALA B CB   1 
ATOM   3443 N N    . SER B 1 242 ? -16.992 -42.675 -32.635 1.00 37.57  ? 229 SER B N    1 
ATOM   3444 C CA   . SER B 1 242 ? -16.865 -41.886 -31.421 1.00 39.06  ? 229 SER B CA   1 
ATOM   3445 C C    . SER B 1 242 ? -15.603 -41.035 -31.508 1.00 35.65  ? 229 SER B C    1 
ATOM   3446 O O    . SER B 1 242 ? -15.592 -39.883 -31.077 1.00 41.68  ? 229 SER B O    1 
ATOM   3447 C CB   . SER B 1 242 ? -16.832 -42.751 -30.199 1.00 35.09  ? 229 SER B CB   1 
ATOM   3448 O OG   . SER B 1 242 ? -18.098 -43.354 -29.988 1.00 37.45  ? 229 SER B OG   1 
ATOM   3449 N N    . ASP B 1 243 ? -14.559 -41.629 -32.083 1.00 37.32  ? 230 ASP B N    1 
ATOM   3450 C CA   . ASP B 1 243 ? -13.299 -40.920 -32.220 1.00 41.43  ? 230 ASP B CA   1 
ATOM   3451 C C    . ASP B 1 243 ? -13.488 -39.647 -33.039 1.00 33.58  ? 230 ASP B C    1 
ATOM   3452 O O    . ASP B 1 243 ? -12.905 -38.628 -32.688 1.00 32.26  ? 230 ASP B O    1 
ATOM   3453 C CB   . ASP B 1 243 ? -12.228 -41.808 -32.802 1.00 39.55  ? 230 ASP B CB   1 
ATOM   3454 C CG   . ASP B 1 243 ? -11.803 -42.947 -31.884 1.00 46.82  ? 230 ASP B CG   1 
ATOM   3455 O OD1  . ASP B 1 243 ? -11.095 -42.656 -30.895 1.00 37.16  ? 230 ASP B OD1  1 
ATOM   3456 O OD2  . ASP B 1 243 ? -12.167 -44.121 -32.180 1.00 36.63  ? 230 ASP B OD2  1 
ATOM   3457 N N    . CYS B 1 244 ? -14.296 -39.727 -34.113 1.00 31.95  ? 231 CYS B N    1 
ATOM   3458 C CA   . CYS B 1 244 ? -14.589 -38.589 -34.976 1.00 30.63  ? 231 CYS B CA   1 
ATOM   3459 C C    . CYS B 1 244 ? -15.391 -37.534 -34.224 1.00 30.60  ? 231 CYS B C    1 
ATOM   3460 O O    . CYS B 1 244 ? -15.099 -36.338 -34.294 1.00 35.52  ? 231 CYS B O    1 
ATOM   3461 C CB   . CYS B 1 244 ? -15.293 -38.985 -36.275 1.00 33.60  ? 231 CYS B CB   1 
ATOM   3462 S SG   . CYS B 1 244 ? -14.334 -40.093 -37.338 1.00 42.24  ? 231 CYS B SG   1 
ATOM   3463 N N    . ALA B 1 245 ? -16.410 -37.982 -33.486 1.00 30.26  ? 232 ALA B N    1 
ATOM   3464 C CA   . ALA B 1 245 ? -17.324 -37.081 -32.822 1.00 29.79  ? 232 ALA B CA   1 
ATOM   3465 C C    . ALA B 1 245 ? -16.617 -36.301 -31.714 1.00 29.35  ? 232 ALA B C    1 
ATOM   3466 O O    . ALA B 1 245 ? -16.862 -35.104 -31.548 1.00 35.50  ? 232 ALA B O    1 
ATOM   3467 C CB   . ALA B 1 245 ? -18.516 -37.874 -32.321 1.00 38.14  ? 232 ALA B CB   1 
ATOM   3468 N N    . ARG B 1 246 ? -15.716 -36.966 -30.990 1.00 31.08  ? 233 ARG B N    1 
ATOM   3469 C CA   . ARG B 1 246 ? -14.935 -36.306 -29.951 1.00 32.67  ? 233 ARG B CA   1 
ATOM   3470 C C    . ARG B 1 246 ? -14.122 -35.165 -30.553 1.00 30.75  ? 233 ARG B C    1 
ATOM   3471 O O    . ARG B 1 246 ? -14.116 -34.054 -29.999 1.00 31.30  ? 233 ARG B O    1 
ATOM   3472 C CB   . ARG B 1 246 ? -14.089 -37.306 -29.169 1.00 31.03  ? 233 ARG B CB   1 
ATOM   3473 C CG   . ARG B 1 246 ? -14.977 -38.172 -28.277 1.00 36.40  ? 233 ARG B CG   1 
ATOM   3474 C CD   . ARG B 1 246 ? -14.605 -39.643 -28.380 1.00 42.20  ? 233 ARG B CD   1 
ATOM   3475 N NE   . ARG B 1 246 ? -14.256 -40.197 -27.076 1.00 56.54  ? 233 ARG B NE   1 
ATOM   3476 C CZ   . ARG B 1 246 ? -13.647 -41.365 -26.943 1.00 72.57  ? 233 ARG B CZ   1 
ATOM   3477 N NH1  . ARG B 1 246 ? -13.745 -42.285 -27.901 1.00 70.20  ? 233 ARG B NH1  1 
ATOM   3478 N NH2  . ARG B 1 246 ? -12.992 -41.615 -25.821 1.00 62.51  ? 233 ARG B NH2  1 
ATOM   3479 N N    . LEU B 1 247 ? -13.543 -35.419 -31.736 1.00 33.99  ? 234 LEU B N    1 
ATOM   3480 C CA   . LEU B 1 247 ? -12.779 -34.374 -32.412 1.00 30.88  ? 234 LEU B CA   1 
ATOM   3481 C C    . LEU B 1 247 ? -13.717 -33.252 -32.846 1.00 34.38  ? 234 LEU B C    1 
ATOM   3482 O O    . LEU B 1 247 ? -13.415 -32.073 -32.628 1.00 32.78  ? 234 LEU B O    1 
ATOM   3483 C CB   . LEU B 1 247 ? -11.934 -34.952 -33.557 1.00 31.23  ? 234 LEU B CB   1 
ATOM   3484 C CG   . LEU B 1 247 ? -11.121 -33.949 -34.393 1.00 31.72  ? 234 LEU B CG   1 
ATOM   3485 C CD1  . LEU B 1 247 ? -10.372 -32.950 -33.523 1.00 35.04  ? 234 LEU B CD1  1 
ATOM   3486 C CD2  . LEU B 1 247 ? -10.120 -34.713 -35.200 1.00 30.16  ? 234 LEU B CD2  1 
ATOM   3487 N N    . ALA B 1 248 ? -14.868 -33.613 -33.458 1.00 31.12  ? 235 ALA B N    1 
ATOM   3488 C CA   . ALA B 1 248 ? -15.863 -32.628 -33.882 1.00 31.26  ? 235 ALA B CA   1 
ATOM   3489 C C    . ALA B 1 248 ? -16.323 -31.678 -32.771 1.00 30.64  ? 235 ALA B C    1 
ATOM   3490 O O    . ALA B 1 248 ? -16.510 -30.473 -33.008 1.00 28.38  ? 235 ALA B O    1 
ATOM   3491 C CB   . ALA B 1 248 ? -17.062 -33.308 -34.523 1.00 33.43  ? 235 ALA B CB   1 
ATOM   3492 N N    . LEU B 1 249 ? -16.547 -32.227 -31.562 1.00 29.91  ? 236 LEU B N    1 
ATOM   3493 C CA   . LEU B 1 249 ? -17.057 -31.403 -30.461 1.00 28.05  ? 236 LEU B CA   1 
ATOM   3494 C C    . LEU B 1 249 ? -16.022 -30.320 -30.138 1.00 27.60  ? 236 LEU B C    1 
ATOM   3495 O O    . LEU B 1 249 ? -16.366 -29.163 -29.896 1.00 28.39  ? 236 LEU B O    1 
ATOM   3496 C CB   . LEU B 1 249 ? -17.316 -32.276 -29.239 1.00 25.46  ? 236 LEU B CB   1 
ATOM   3497 C CG   . LEU B 1 249 ? -18.490 -33.278 -29.342 1.00 28.82  ? 236 LEU B CG   1 
ATOM   3498 C CD1  . LEU B 1 249 ? -18.506 -34.177 -28.125 1.00 26.78  ? 236 LEU B CD1  1 
ATOM   3499 C CD2  . LEU B 1 249 ? -19.848 -32.614 -29.531 1.00 30.70  ? 236 LEU B CD2  1 
ATOM   3500 N N    . PHE B 1 250 ? -14.748 -30.720 -30.130 1.00 26.62  ? 237 PHE B N    1 
ATOM   3501 C CA   . PHE B 1 250 ? -13.669 -29.805 -29.785 1.00 30.53  ? 237 PHE B CA   1 
ATOM   3502 C C    . PHE B 1 250 ? -13.605 -28.688 -30.829 1.00 30.47  ? 237 PHE B C    1 
ATOM   3503 O O    . PHE B 1 250 ? -13.480 -27.513 -30.489 1.00 28.94  ? 237 PHE B O    1 
ATOM   3504 C CB   . PHE B 1 250 ? -12.340 -30.556 -29.610 1.00 32.82  ? 237 PHE B CB   1 
ATOM   3505 C CG   . PHE B 1 250 ? -11.178 -29.576 -29.433 1.00 29.61  ? 237 PHE B CG   1 
ATOM   3506 C CD1  . PHE B 1 250 ? -10.928 -28.978 -28.207 1.00 30.29  ? 237 PHE B CD1  1 
ATOM   3507 C CD2  . PHE B 1 250 ? -10.383 -29.227 -30.513 1.00 32.14  ? 237 PHE B CD2  1 
ATOM   3508 C CE1  . PHE B 1 250 ? -9.910  -28.031 -28.070 1.00 36.32  ? 237 PHE B CE1  1 
ATOM   3509 C CE2  . PHE B 1 250 ? -9.362  -28.290 -30.370 1.00 35.76  ? 237 PHE B CE2  1 
ATOM   3510 C CZ   . PHE B 1 250 ? -9.118  -27.710 -29.145 1.00 31.93  ? 237 PHE B CZ   1 
ATOM   3511 N N    . LEU B 1 251 ? -13.706 -29.069 -32.114 1.00 36.13  ? 238 LEU B N    1 
ATOM   3512 C CA   . LEU B 1 251 ? -13.584 -28.144 -33.238 1.00 31.81  ? 238 LEU B CA   1 
ATOM   3513 C C    . LEU B 1 251 ? -14.786 -27.216 -33.314 1.00 35.64  ? 238 LEU B C    1 
ATOM   3514 O O    . LEU B 1 251 ? -14.681 -26.113 -33.873 1.00 33.89  ? 238 LEU B O    1 
ATOM   3515 C CB   . LEU B 1 251 ? -13.358 -28.893 -34.560 1.00 30.58  ? 238 LEU B CB   1 
ATOM   3516 C CG   . LEU B 1 251 ? -11.974 -29.542 -34.721 1.00 35.13  ? 238 LEU B CG   1 
ATOM   3517 C CD1  . LEU B 1 251 ? -11.842 -30.475 -35.910 1.00 30.96  ? 238 LEU B CD1  1 
ATOM   3518 C CD2  . LEU B 1 251 ? -10.921 -28.440 -34.833 1.00 34.49  ? 238 LEU B CD2  1 
ATOM   3519 N N    . ALA B 1 252 ? -15.920 -27.661 -32.738 1.00 31.63  ? 239 ALA B N    1 
ATOM   3520 C CA   . ALA B 1 252 ? -17.104 -26.819 -32.679 1.00 29.97  ? 239 ALA B CA   1 
ATOM   3521 C C    . ALA B 1 252 ? -17.107 -25.875 -31.478 1.00 30.44  ? 239 ALA B C    1 
ATOM   3522 O O    . ALA B 1 252 ? -17.662 -24.783 -31.573 1.00 32.33  ? 239 ALA B O    1 
ATOM   3523 C CB   . ALA B 1 252 ? -18.364 -27.661 -32.710 1.00 33.16  ? 239 ALA B CB   1 
ATOM   3524 N N    . SER B 1 253 ? -16.534 -26.305 -30.352 1.00 30.08  ? 240 SER B N    1 
ATOM   3525 C CA   . SER B 1 253 ? -16.633 -25.575 -29.098 1.00 32.19  ? 240 SER B CA   1 
ATOM   3526 C C    . SER B 1 253 ? -15.772 -24.304 -29.120 1.00 33.52  ? 240 SER B C    1 
ATOM   3527 O O    . SER B 1 253 ? -14.953 -24.113 -30.013 1.00 39.59  ? 240 SER B O    1 
ATOM   3528 C CB   . SER B 1 253 ? -16.208 -26.457 -27.947 1.00 29.58  ? 240 SER B CB   1 
ATOM   3529 O OG   . SER B 1 253 ? -14.798 -26.586 -27.922 1.00 35.06  ? 240 SER B OG   1 
ATOM   3530 N N    . ASP B 1 254 ? -15.918 -23.465 -28.082 1.00 30.82  ? 241 ASP B N    1 
ATOM   3531 C CA   . ASP B 1 254 ? -15.124 -22.259 -27.900 1.00 30.59  ? 241 ASP B CA   1 
ATOM   3532 C C    . ASP B 1 254 ? -13.678 -22.598 -27.510 1.00 30.62  ? 241 ASP B C    1 
ATOM   3533 O O    . ASP B 1 254 ? -12.798 -21.747 -27.503 1.00 30.89  ? 241 ASP B O    1 
ATOM   3534 C CB   . ASP B 1 254 ? -15.734 -21.339 -26.854 1.00 37.53  ? 241 ASP B CB   1 
ATOM   3535 C CG   . ASP B 1 254 ? -17.025 -20.626 -27.216 1.00 41.92  ? 241 ASP B CG   1 
ATOM   3536 O OD1  . ASP B 1 254 ? -17.483 -20.717 -28.397 1.00 42.32  ? 241 ASP B OD1  1 
ATOM   3537 O OD2  . ASP B 1 254 ? -17.590 -20.007 -26.287 1.00 52.44  ? 241 ASP B OD2  1 
ATOM   3538 N N    . ASP B 1 255 ? -13.394 -23.876 -27.248 1.00 34.84  ? 242 ASP B N    1 
ATOM   3539 C CA   . ASP B 1 255 ? -12.035 -24.251 -26.891 1.00 34.66  ? 242 ASP B CA   1 
ATOM   3540 C C    . ASP B 1 255 ? -11.104 -24.271 -28.104 1.00 33.04  ? 242 ASP B C    1 
ATOM   3541 O O    . ASP B 1 255 ? -9.889  -24.417 -27.922 1.00 33.39  ? 242 ASP B O    1 
ATOM   3542 C CB   . ASP B 1 255 ? -11.953 -25.630 -26.253 1.00 30.94  ? 242 ASP B CB   1 
ATOM   3543 C CG   . ASP B 1 255 ? -12.605 -25.727 -24.884 1.00 34.52  ? 242 ASP B CG   1 
ATOM   3544 O OD1  . ASP B 1 255 ? -13.824 -25.835 -24.866 1.00 35.36  ? 242 ASP B OD1  1 
ATOM   3545 O OD2  . ASP B 1 255 ? -11.879 -25.700 -23.855 1.00 32.31  ? 242 ASP B OD2  1 
ATOM   3546 N N    . SER B 1 256 ? -11.666 -24.218 -29.323 1.00 28.51  ? 243 SER B N    1 
ATOM   3547 C CA   . SER B 1 256 ? -10.862 -24.162 -30.533 1.00 28.37  ? 243 SER B CA   1 
ATOM   3548 C C    . SER B 1 256 ? -11.023 -22.809 -31.215 1.00 27.59  ? 243 SER B C    1 
ATOM   3549 O O    . SER B 1 256 ? -10.821 -22.707 -32.404 1.00 27.28  ? 243 SER B O    1 
ATOM   3550 C CB   . SER B 1 256 ? -11.182 -25.286 -31.496 1.00 32.14  ? 243 SER B CB   1 
ATOM   3551 O OG   . SER B 1 256 ? -12.571 -25.348 -31.772 1.00 37.08  ? 243 SER B OG   1 
ATOM   3552 N N    . ARG B 1 257 ? -11.429 -21.781 -30.455 1.00 28.77  ? 244 ARG B N    1 
ATOM   3553 C CA   . ARG B 1 257 ? -11.814 -20.492 -31.023 1.00 31.30  ? 244 ARG B CA   1 
ATOM   3554 C C    . ARG B 1 257 ? -10.708 -19.914 -31.909 1.00 33.72  ? 244 ARG B C    1 
ATOM   3555 O O    . ARG B 1 257 ? -11.012 -19.226 -32.875 1.00 35.25  ? 244 ARG B O    1 
ATOM   3556 C CB   . ARG B 1 257 ? -12.252 -19.503 -29.920 1.00 35.11  ? 244 ARG B CB   1 
ATOM   3557 C CG   . ARG B 1 257 ? -11.303 -19.108 -28.794 1.00 40.08  ? 244 ARG B CG   1 
ATOM   3558 C CD   . ARG B 1 257 ? -10.727 -17.696 -29.009 1.00 50.23  ? 244 ARG B CD   1 
ATOM   3559 N NE   . ARG B 1 257 ? -9.468  -17.268 -28.373 1.00 41.59  ? 244 ARG B NE   1 
ATOM   3560 C CZ   . ARG B 1 257 ? -9.132  -15.980 -28.182 1.00 46.96  ? 244 ARG B CZ   1 
ATOM   3561 N NH1  . ARG B 1 257 ? -10.063 -15.048 -28.332 1.00 55.84  ? 244 ARG B NH1  1 
ATOM   3562 N NH2  . ARG B 1 257 ? -7.913  -15.607 -27.778 1.00 41.76  ? 244 ARG B NH2  1 
ATOM   3563 N N    . GLY B 1 258 ? -9.429  -20.172 -31.582 1.00 32.77  ? 245 GLY B N    1 
ATOM   3564 C CA   . GLY B 1 258 ? -8.328  -19.559 -32.315 1.00 31.16  ? 245 GLY B CA   1 
ATOM   3565 C C    . GLY B 1 258 ? -7.828  -20.428 -33.475 1.00 28.75  ? 245 GLY B C    1 
ATOM   3566 O O    . GLY B 1 258 ? -6.844  -20.076 -34.124 1.00 29.17  ? 245 GLY B O    1 
ATOM   3567 N N    . CYS B 1 259 ? -8.488  -21.571 -33.738 1.00 26.29  ? 246 CYS B N    1 
ATOM   3568 C CA   . CYS B 1 259 ? -8.006  -22.509 -34.761 1.00 23.71  ? 246 CYS B CA   1 
ATOM   3569 C C    . CYS B 1 259 ? -8.794  -22.315 -36.050 1.00 23.96  ? 246 CYS B C    1 
ATOM   3570 O O    . CYS B 1 259 ? -10.019 -22.350 -36.050 1.00 29.82  ? 246 CYS B O    1 
ATOM   3571 C CB   . CYS B 1 259 ? -8.182  -23.958 -34.303 1.00 22.05  ? 246 CYS B CB   1 
ATOM   3572 S SG   . CYS B 1 259 ? -7.249  -24.399 -32.816 1.00 30.13  ? 246 CYS B SG   1 
ATOM   3573 N N    . THR B 1 260 ? -8.117  -22.028 -37.159 1.00 22.70  ? 247 THR B N    1 
ATOM   3574 C CA   . THR B 1 260 ? -8.798  -21.908 -38.442 1.00 24.71  ? 247 THR B CA   1 
ATOM   3575 C C    . THR B 1 260 ? -7.815  -22.246 -39.557 1.00 22.60  ? 247 THR B C    1 
ATOM   3576 O O    . THR B 1 260 ? -6.607  -22.120 -39.377 1.00 24.54  ? 247 THR B O    1 
ATOM   3577 C CB   . THR B 1 260 ? -9.367  -20.492 -38.620 1.00 26.16  ? 247 THR B CB   1 
ATOM   3578 O OG1  . THR B 1 260 ? -10.345 -20.639 -39.652 1.00 26.53  ? 247 THR B OG1  1 
ATOM   3579 C CG2  . THR B 1 260 ? -8.263  -19.464 -38.853 1.00 22.33  ? 247 THR B CG2  1 
ATOM   3580 N N    . GLY B 1 261 ? -8.376  -22.660 -40.697 1.00 22.93  ? 248 GLY B N    1 
ATOM   3581 C CA   . GLY B 1 261 ? -7.632  -22.979 -41.901 1.00 24.24  ? 248 GLY B CA   1 
ATOM   3582 C C    . GLY B 1 261 ? -6.895  -24.305 -41.842 1.00 28.08  ? 248 GLY B C    1 
ATOM   3583 O O    . GLY B 1 261 ? -6.062  -24.583 -42.718 1.00 28.93  ? 248 GLY B O    1 
ATOM   3584 N N    . GLN B 1 262 ? -7.180  -25.126 -40.824 1.00 27.35  ? 249 GLN B N    1 
ATOM   3585 C CA   . GLN B 1 262 ? -6.250  -26.216 -40.525 1.00 24.18  ? 249 GLN B CA   1 
ATOM   3586 C C    . GLN B 1 262 ? -6.888  -27.595 -40.674 1.00 27.17  ? 249 GLN B C    1 
ATOM   3587 O O    . GLN B 1 262 ? -8.086  -27.766 -40.534 1.00 29.88  ? 249 GLN B O    1 
ATOM   3588 C CB   . GLN B 1 262 ? -5.746  -26.028 -39.094 1.00 23.15  ? 249 GLN B CB   1 
ATOM   3589 C CG   . GLN B 1 262 ? -4.667  -24.949 -38.980 1.00 27.56  ? 249 GLN B CG   1 
ATOM   3590 C CD   . GLN B 1 262 ? -3.424  -25.355 -39.755 1.00 31.85  ? 249 GLN B CD   1 
ATOM   3591 O OE1  . GLN B 1 262 ? -3.050  -26.538 -39.787 1.00 35.55  ? 249 GLN B OE1  1 
ATOM   3592 N NE2  . GLN B 1 262 ? -2.826  -24.416 -40.465 1.00 27.15  ? 249 GLN B NE2  1 
ATOM   3593 N N    . ASN B 1 263 ? -6.051  -28.603 -40.863 1.00 26.96  ? 250 ASN B N    1 
ATOM   3594 C CA   . ASN B 1 263 ? -6.494  -29.984 -40.758 1.00 31.85  ? 250 ASN B CA   1 
ATOM   3595 C C    . ASN B 1 263 ? -6.289  -30.501 -39.330 1.00 32.33  ? 250 ASN B C    1 
ATOM   3596 O O    . ASN B 1 263 ? -5.284  -30.193 -38.694 1.00 30.88  ? 250 ASN B O    1 
ATOM   3597 C CB   . ASN B 1 263 ? -5.659  -30.880 -41.665 1.00 27.37  ? 250 ASN B CB   1 
ATOM   3598 C CG   . ASN B 1 263 ? -6.002  -30.736 -43.132 1.00 30.61  ? 250 ASN B CG   1 
ATOM   3599 O OD1  . ASN B 1 263 ? -7.109  -30.360 -43.508 1.00 34.12  ? 250 ASN B OD1  1 
ATOM   3600 N ND2  . ASN B 1 263 ? -5.101  -31.135 -44.010 1.00 34.20  ? 250 ASN B ND2  1 
ATOM   3601 N N    . PHE B 1 264 ? -7.205  -31.362 -38.855 1.00 29.01  ? 251 PHE B N    1 
ATOM   3602 C CA   . PHE B 1 264 ? -6.996  -32.096 -37.615 1.00 24.73  ? 251 PHE B CA   1 
ATOM   3603 C C    . PHE B 1 264 ? -7.217  -33.571 -37.939 1.00 27.26  ? 251 PHE B C    1 
ATOM   3604 O O    . PHE B 1 264 ? -8.319  -33.945 -38.337 1.00 25.86  ? 251 PHE B O    1 
ATOM   3605 C CB   . PHE B 1 264 ? -8.072  -31.550 -36.672 1.00 29.10  ? 251 PHE B CB   1 
ATOM   3606 C CG   . PHE B 1 264 ? -7.830  -30.108 -36.245 1.00 27.84  ? 251 PHE B CG   1 
ATOM   3607 C CD1  . PHE B 1 264 ? -8.290  -29.048 -37.017 1.00 29.95  ? 251 PHE B CD1  1 
ATOM   3608 C CD2  . PHE B 1 264 ? -7.085  -29.815 -35.107 1.00 37.51  ? 251 PHE B CD2  1 
ATOM   3609 C CE1  . PHE B 1 264 ? -8.021  -27.732 -36.649 1.00 31.75  ? 251 PHE B CE1  1 
ATOM   3610 C CE2  . PHE B 1 264 ? -6.832  -28.487 -34.736 1.00 37.99  ? 251 PHE B CE2  1 
ATOM   3611 C CZ   . PHE B 1 264 ? -7.298  -27.449 -35.513 1.00 33.76  ? 251 PHE B CZ   1 
ATOM   3612 N N    . VAL B 1 265 ? -6.175  -34.386 -37.789 1.00 29.47  ? 252 VAL B N    1 
ATOM   3613 C CA   . VAL B 1 265 ? -6.210  -35.732 -38.337 1.00 32.29  ? 252 VAL B CA   1 
ATOM   3614 C C    . VAL B 1 265 ? -6.373  -36.721 -37.191 1.00 30.36  ? 252 VAL B C    1 
ATOM   3615 O O    . VAL B 1 265 ? -5.562  -36.714 -36.265 1.00 30.99  ? 252 VAL B O    1 
ATOM   3616 C CB   . VAL B 1 265 ? -4.909  -35.976 -39.117 1.00 33.25  ? 252 VAL B CB   1 
ATOM   3617 C CG1  . VAL B 1 265 ? -4.821  -37.409 -39.636 1.00 27.24  ? 252 VAL B CG1  1 
ATOM   3618 C CG2  . VAL B 1 265 ? -4.688  -34.923 -40.230 1.00 31.47  ? 252 VAL B CG2  1 
ATOM   3619 N N    . VAL B 1 266 ? -7.422  -37.557 -37.281 1.00 29.34  ? 253 VAL B N    1 
ATOM   3620 C CA   . VAL B 1 266 ? -7.699  -38.570 -36.273 1.00 27.75  ? 253 VAL B CA   1 
ATOM   3621 C C    . VAL B 1 266 ? -7.626  -39.932 -36.951 1.00 27.09  ? 253 VAL B C    1 
ATOM   3622 O O    . VAL B 1 266 ? -8.600  -40.394 -37.522 1.00 29.63  ? 253 VAL B O    1 
ATOM   3623 C CB   . VAL B 1 266 ? -9.021  -38.347 -35.504 1.00 32.84  ? 253 VAL B CB   1 
ATOM   3624 C CG1  . VAL B 1 266 ? -10.236 -38.157 -36.399 1.00 37.56  ? 253 VAL B CG1  1 
ATOM   3625 C CG2  . VAL B 1 266 ? -9.296  -39.396 -34.428 1.00 33.15  ? 253 VAL B CG2  1 
ATOM   3626 N N    . ASP B 1 267 ? -6.461  -40.566 -36.897 1.00 29.01  ? 254 ASP B N    1 
ATOM   3627 C CA   . ASP B 1 267 ? -6.195  -41.700 -37.776 1.00 30.96  ? 254 ASP B CA   1 
ATOM   3628 C C    . ASP B 1 267 ? -5.279  -42.738 -37.135 1.00 32.12  ? 254 ASP B C    1 
ATOM   3629 O O    . ASP B 1 267 ? -4.829  -43.653 -37.813 1.00 31.40  ? 254 ASP B O    1 
ATOM   3630 C CB   . ASP B 1 267 ? -5.598  -41.179 -39.080 1.00 35.26  ? 254 ASP B CB   1 
ATOM   3631 C CG   . ASP B 1 267 ? -4.140  -40.762 -39.056 1.00 30.59  ? 254 ASP B CG   1 
ATOM   3632 O OD1  . ASP B 1 267 ? -3.593  -40.558 -37.948 1.00 31.97  ? 254 ASP B OD1  1 
ATOM   3633 O OD2  . ASP B 1 267 ? -3.532  -40.738 -40.163 1.00 31.60  ? 254 ASP B OD2  1 
ATOM   3634 N N    . ALA B 1 268 ? -4.967  -42.595 -35.835 1.00 36.76  ? 255 ALA B N    1 
ATOM   3635 C CA   . ALA B 1 268 ? -4.155  -43.604 -35.158 1.00 35.41  ? 255 ALA B CA   1 
ATOM   3636 C C    . ALA B 1 268 ? -2.853  -43.800 -35.914 1.00 37.97  ? 255 ALA B C    1 
ATOM   3637 O O    . ALA B 1 268 ? -2.221  -44.842 -35.787 1.00 43.37  ? 255 ALA B O    1 
ATOM   3638 C CB   . ALA B 1 268 ? -4.924  -44.925 -35.043 1.00 36.67  ? 255 ALA B CB   1 
ATOM   3639 N N    . GLY B 1 269 ? -2.439  -42.792 -36.705 1.00 46.43  ? 256 GLY B N    1 
ATOM   3640 C CA   . GLY B 1 269 ? -1.157  -42.867 -37.402 1.00 38.39  ? 256 GLY B CA   1 
ATOM   3641 C C    . GLY B 1 269 ? -1.203  -43.550 -38.780 1.00 37.38  ? 256 GLY B C    1 
ATOM   3642 O O    . GLY B 1 269 ? -0.159  -43.719 -39.397 1.00 39.31  ? 256 GLY B O    1 
ATOM   3643 N N    . LEU B 1 270 ? -2.395  -43.882 -39.305 1.00 36.37  ? 257 LEU B N    1 
ATOM   3644 C CA   . LEU B 1 270 ? -2.499  -44.659 -40.543 1.00 37.14  ? 257 LEU B CA   1 
ATOM   3645 C C    . LEU B 1 270 ? -1.875  -43.902 -41.720 1.00 37.74  ? 257 LEU B C    1 
ATOM   3646 O O    . LEU B 1 270 ? -1.335  -44.542 -42.629 1.00 37.86  ? 257 LEU B O    1 
ATOM   3647 C CB   . LEU B 1 270 ? -3.938  -45.065 -40.855 1.00 34.35  ? 257 LEU B CB   1 
ATOM   3648 C CG   . LEU B 1 270 ? -4.188  -46.063 -41.994 1.00 33.53  ? 257 LEU B CG   1 
ATOM   3649 C CD1  . LEU B 1 270 ? -3.449  -47.346 -41.778 1.00 39.47  ? 257 LEU B CD1  1 
ATOM   3650 C CD2  . LEU B 1 270 ? -5.687  -46.327 -42.172 1.00 34.59  ? 257 LEU B CD2  1 
ATOM   3651 N N    . SER B 1 271 ? -1.926  -42.553 -41.674 1.00 35.21  ? 258 SER B N    1 
ATOM   3652 C CA   . SER B 1 271 ? -1.475  -41.722 -42.787 1.00 33.69  ? 258 SER B CA   1 
ATOM   3653 C C    . SER B 1 271 ? 0.044   -41.566 -42.819 1.00 32.31  ? 258 SER B C    1 
ATOM   3654 O O    . SER B 1 271 ? 0.571   -40.971 -43.751 1.00 32.92  ? 258 SER B O    1 
ATOM   3655 C CB   . SER B 1 271 ? -2.125  -40.357 -42.736 1.00 35.14  ? 258 SER B CB   1 
ATOM   3656 O OG   . SER B 1 271 ? -1.621  -39.642 -41.616 1.00 34.88  ? 258 SER B OG   1 
ATOM   3657 N N    . ILE B 1 272 ? 0.745   -42.037 -41.780 1.00 30.77  ? 259 ILE B N    1 
ATOM   3658 C CA   . ILE B 1 272 ? 2.189   -41.896 -41.679 1.00 33.69  ? 259 ILE B CA   1 
ATOM   3659 C C    . ILE B 1 272 ? 2.851   -43.275 -41.628 1.00 38.35  ? 259 ILE B C    1 
ATOM   3660 O O    . ILE B 1 272 ? 3.082   -43.816 -40.537 1.00 40.40  ? 259 ILE B O    1 
ATOM   3661 C CB   . ILE B 1 272 ? 2.540   -41.030 -40.451 1.00 34.45  ? 259 ILE B CB   1 
ATOM   3662 C CG1  . ILE B 1 272 ? 1.939   -39.630 -40.583 1.00 38.21  ? 259 ILE B CG1  1 
ATOM   3663 C CG2  . ILE B 1 272 ? 4.057   -40.950 -40.270 1.00 33.58  ? 259 ILE B CG2  1 
ATOM   3664 C CD1  . ILE B 1 272 ? 2.244   -38.728 -39.395 1.00 44.52  ? 259 ILE B CD1  1 
ATOM   3665 N N    . GLN B 1 273 ? 3.157   -43.826 -42.806 1.00 39.91  ? 260 GLN B N    1 
ATOM   3666 C CA   . GLN B 1 273 ? 3.560   -45.222 -42.940 1.00 49.67  ? 260 GLN B CA   1 
ATOM   3667 C C    . GLN B 1 273 ? 4.804   -45.356 -43.834 1.00 53.76  ? 260 GLN B C    1 
ATOM   3668 O O    . GLN B 1 273 ? 5.013   -44.451 -44.664 1.00 41.16  ? 260 GLN B O    1 
ATOM   3669 C CB   . GLN B 1 273 ? 2.507   -46.060 -43.665 1.00 41.27  ? 260 GLN B CB   1 
ATOM   3670 C CG   . GLN B 1 273 ? 1.350   -46.486 -42.786 1.00 42.87  ? 260 GLN B CG   1 
ATOM   3671 C CD   . GLN B 1 273 ? 0.542   -47.581 -43.442 1.00 49.20  ? 260 GLN B CD   1 
ATOM   3672 O OE1  . GLN B 1 273 ? 1.050   -48.693 -43.638 1.00 54.13  ? 260 GLN B OE1  1 
ATOM   3673 N NE2  . GLN B 1 273 ? -0.706  -47.278 -43.768 1.00 41.11  ? 260 GLN B NE2  1 
ATOM   3674 O OXT  . GLN B 1 273 ? 5.491   -46.411 -43.721 1.00 55.42  ? 260 GLN B OXT  1 
HETATM 3675 C C1   . YZT C 2 .   ? 6.864   -18.401 -31.744 0.50 32.11  ? 301 YZT A C1   1 
HETATM 3676 C C2   . YZT C 2 .   ? 7.930   -17.337 -31.671 0.50 29.84  ? 301 YZT A C2   1 
HETATM 3677 C C3   . YZT C 2 .   ? 7.231   -16.029 -31.731 0.50 28.05  ? 301 YZT A C3   1 
HETATM 3678 C C4   . YZT C 2 .   ? 6.572   -15.893 -33.096 0.50 30.14  ? 301 YZT A C4   1 
HETATM 3679 C C5   . YZT C 2 .   ? 5.633   -17.122 -33.372 0.50 29.08  ? 301 YZT A C5   1 
HETATM 3680 C C6   . YZT C 2 .   ? 5.031   -17.228 -34.766 0.50 25.90  ? 301 YZT A C6   1 
HETATM 3681 O O1   . YZT C 2 .   ? 7.354   -19.672 -31.438 0.50 36.49  ? 301 YZT A O1   1 
HETATM 3682 O O1S6 . YZT C 2 .   ? 5.545   -14.947 -35.888 0.50 25.64  ? 301 YZT A O1S6 1 
HETATM 3683 O O2   . YZT C 2 .   ? 8.711   -17.405 -30.478 0.50 31.85  ? 301 YZT A O2   1 
HETATM 3684 O O2S6 . YZT C 2 .   ? 5.250   -16.865 -37.280 0.50 20.95  ? 301 YZT A O2S6 1 
HETATM 3685 O O3   . YZT C 2 .   ? 8.171   -14.999 -31.427 0.50 29.99  ? 301 YZT A O3   1 
HETATM 3686 O O3S6 . YZT C 2 .   ? 7.276   -16.675 -35.960 0.50 27.61  ? 301 YZT A O3S6 1 
HETATM 3687 O O4   . YZT C 2 .   ? 5.801   -14.692 -33.121 0.50 31.70  ? 301 YZT A O4   1 
HETATM 3688 O O5   . YZT C 2 .   ? 6.309   -18.365 -33.073 0.50 31.48  ? 301 YZT A O5   1 
HETATM 3689 S S6   . YZT C 2 .   ? 5.873   -16.463 -36.133 0.50 24.24  ? 301 YZT A S6   1 
HETATM 3690 O O    . HOH D 3 .   ? -14.501 -34.176 -27.078 1.00 39.76  ? 401 HOH A O    1 
HETATM 3691 O O    . HOH D 3 .   ? -10.059 -27.828 -23.782 1.00 35.02  ? 402 HOH A O    1 
HETATM 3692 O O    . HOH D 3 .   ? -1.510  -41.588 -13.119 1.00 35.04  ? 403 HOH A O    1 
HETATM 3693 O O    . HOH D 3 .   ? 11.032  -42.993 -9.733  1.00 48.31  ? 404 HOH A O    1 
HETATM 3694 O O    . HOH D 3 .   ? -3.115  -15.669 -49.053 1.00 38.50  ? 405 HOH A O    1 
HETATM 3695 O O    . HOH D 3 .   ? -1.887  -50.107 -24.467 1.00 42.45  ? 406 HOH A O    1 
HETATM 3696 O O    . HOH D 3 .   ? 16.923  -23.097 -10.588 1.00 53.69  ? 407 HOH A O    1 
HETATM 3697 O O    . HOH D 3 .   ? 1.656   -43.037 -31.061 1.00 34.54  ? 408 HOH A O    1 
HETATM 3698 O O    . HOH D 3 .   ? -4.002  -35.397 -5.612  1.00 48.65  ? 409 HOH A O    1 
HETATM 3699 O O    . HOH D 3 .   ? -12.923 -36.831 -20.468 1.00 49.29  ? 410 HOH A O    1 
HETATM 3700 O O    . HOH D 3 .   ? 21.846  -28.626 -13.297 1.00 42.69  ? 411 HOH A O    1 
HETATM 3701 O O    . HOH D 3 .   ? -3.701  -32.817 -37.226 1.00 39.38  ? 412 HOH A O    1 
HETATM 3702 O O    . HOH D 3 .   ? -1.126  -39.259 -38.074 1.00 38.40  ? 413 HOH A O    1 
HETATM 3703 O O    . HOH D 3 .   ? -3.320  -5.920  -30.469 1.00 43.05  ? 414 HOH A O    1 
HETATM 3704 O O    . HOH D 3 .   ? -1.956  -13.699 -32.184 1.00 28.89  ? 415 HOH A O    1 
HETATM 3705 O O    . HOH D 3 .   ? 15.254  -23.116 -39.257 1.00 28.12  ? 416 HOH A O    1 
HETATM 3706 O O    . HOH D 3 .   ? -8.841  -26.050 -17.050 1.00 27.77  ? 417 HOH A O    1 
HETATM 3707 O O    . HOH D 3 .   ? 2.402   -27.122 -4.733  1.00 52.91  ? 418 HOH A O    1 
HETATM 3708 O O    . HOH D 3 .   ? -3.603  -28.169 -5.816  1.00 39.09  ? 419 HOH A O    1 
HETATM 3709 O O    . HOH D 3 .   ? -5.673  -30.384 -9.502  1.00 35.00  ? 420 HOH A O    1 
HETATM 3710 O O    . HOH D 3 .   ? -10.637 -37.774 -31.207 1.00 29.40  ? 421 HOH A O    1 
HETATM 3711 O O    . HOH D 3 .   ? 18.860  -12.312 -28.768 1.00 43.26  ? 422 HOH A O    1 
HETATM 3712 O O    . HOH D 3 .   ? -4.754  -43.725 -26.920 1.00 52.19  ? 423 HOH A O    1 
HETATM 3713 O O    . HOH D 3 .   ? 12.198  -42.691 -33.800 1.00 25.08  ? 424 HOH A O    1 
HETATM 3714 O O    . HOH D 3 .   ? 2.941   -34.627 -37.980 1.00 26.03  ? 425 HOH A O    1 
HETATM 3715 O O    . HOH D 3 .   ? 6.200   -22.116 -24.745 1.00 28.06  ? 426 HOH A O    1 
HETATM 3716 O O    . HOH D 3 .   ? 15.427  -25.406 -17.644 1.00 28.38  ? 427 HOH A O    1 
HETATM 3717 O O    . HOH D 3 .   ? 10.926  -30.926 -22.012 1.00 28.80  ? 428 HOH A O    1 
HETATM 3718 O O    . HOH D 3 .   ? 27.680  -24.201 -25.822 1.00 38.03  ? 429 HOH A O    1 
HETATM 3719 O O    . HOH D 3 .   ? -11.487 -33.604 -14.545 1.00 33.89  ? 430 HOH A O    1 
HETATM 3720 O O    . HOH D 3 .   ? 8.708   -18.232 -4.457  1.00 48.55  ? 431 HOH A O    1 
HETATM 3721 O O    . HOH D 3 .   ? 0.787   -17.503 -18.345 1.00 30.92  ? 432 HOH A O    1 
HETATM 3722 O O    . HOH D 3 .   ? -5.018  -22.414 -36.437 1.00 23.10  ? 433 HOH A O    1 
HETATM 3723 O O    . HOH D 3 .   ? -0.335  -24.187 -41.717 1.00 35.94  ? 434 HOH A O    1 
HETATM 3724 O O    . HOH D 3 .   ? -7.274  -23.756 -28.760 1.00 25.28  ? 435 HOH A O    1 
HETATM 3725 O O    . HOH D 3 .   ? 6.467   -42.339 -16.624 1.00 38.68  ? 436 HOH A O    1 
HETATM 3726 O O    . HOH D 3 .   ? 4.425   -15.657 -17.070 1.00 41.80  ? 437 HOH A O    1 
HETATM 3727 O O    . HOH D 3 .   ? 7.218   -12.836 -36.301 1.00 36.26  ? 438 HOH A O    1 
HETATM 3728 O O    . HOH D 3 .   ? 16.803  -18.901 -29.828 1.00 29.26  ? 439 HOH A O    1 
HETATM 3729 O O    . HOH D 3 .   ? 15.056  -18.601 -38.180 1.00 32.02  ? 440 HOH A O    1 
HETATM 3730 O O    . HOH D 3 .   ? 18.891  -34.322 -8.833  1.00 47.49  ? 441 HOH A O    1 
HETATM 3731 O O    . HOH D 3 .   ? -7.684  -11.392 -43.569 1.00 33.09  ? 442 HOH A O    1 
HETATM 3732 O O    . HOH D 3 .   ? 6.592   -21.439 -21.337 1.00 31.27  ? 443 HOH A O    1 
HETATM 3733 O O    . HOH D 3 .   ? -0.906  -16.385 -34.688 1.00 33.96  ? 444 HOH A O    1 
HETATM 3734 O O    . HOH D 3 .   ? 19.247  -27.946 -12.976 1.00 35.38  ? 445 HOH A O    1 
HETATM 3735 O O    . HOH D 3 .   ? 1.350   -19.266 -47.043 1.00 30.03  ? 446 HOH A O    1 
HETATM 3736 O O    . HOH D 3 .   ? 4.467   -12.234 -38.852 1.00 28.86  ? 447 HOH A O    1 
HETATM 3737 O O    . HOH D 3 .   ? 12.780  -45.404 -22.812 1.00 33.11  ? 448 HOH A O    1 
HETATM 3738 O O    . HOH D 3 .   ? 5.539   -29.730 -34.998 1.00 32.82  ? 449 HOH A O    1 
HETATM 3739 O O    . HOH D 3 .   ? -16.875 -25.085 -23.287 1.00 35.68  ? 450 HOH A O    1 
HETATM 3740 O O    . HOH D 3 .   ? -6.871  -9.100  -29.629 1.00 37.84  ? 451 HOH A O    1 
HETATM 3741 O O    . HOH D 3 .   ? -4.392  -16.868 -12.679 1.00 38.76  ? 452 HOH A O    1 
HETATM 3742 O O    . HOH D 3 .   ? -2.085  -42.535 -19.383 1.00 38.16  ? 453 HOH A O    1 
HETATM 3743 O O    . HOH D 3 .   ? 15.979  -40.055 -20.606 1.00 31.81  ? 454 HOH A O    1 
HETATM 3744 O O    . HOH D 3 .   ? 19.183  -17.094 -37.835 1.00 29.73  ? 455 HOH A O    1 
HETATM 3745 O O    . HOH D 3 .   ? 23.249  -30.157 -33.941 1.00 35.51  ? 456 HOH A O    1 
HETATM 3746 O O    . HOH D 3 .   ? 0.344   -41.974 -12.249 1.00 35.76  ? 457 HOH A O    1 
HETATM 3747 O O    . HOH D 3 .   ? 5.894   -19.424 -22.984 1.00 42.83  ? 458 HOH A O    1 
HETATM 3748 O O    . HOH D 3 .   ? 6.911   -27.438 -35.199 1.00 30.38  ? 459 HOH A O    1 
HETATM 3749 O O    . HOH D 3 .   ? 4.538   -33.520 -36.110 1.00 27.56  ? 460 HOH A O    1 
HETATM 3750 O O    . HOH D 3 .   ? 19.648  -42.053 -21.722 1.00 47.82  ? 461 HOH A O    1 
HETATM 3751 O O    . HOH D 3 .   ? 4.379   -17.100 -29.796 1.00 40.99  ? 462 HOH A O    1 
HETATM 3752 O O    . HOH D 3 .   ? -9.614  -39.720 -14.960 1.00 34.98  ? 463 HOH A O    1 
HETATM 3753 O O    . HOH D 3 .   ? 19.090  -30.941 -23.207 1.00 29.07  ? 464 HOH A O    1 
HETATM 3754 O O    . HOH D 3 .   ? -4.506  -38.847 -20.230 1.00 37.54  ? 465 HOH A O    1 
HETATM 3755 O O    . HOH D 3 .   ? 6.918   -16.388 -23.981 1.00 51.02  ? 466 HOH A O    1 
HETATM 3756 O O    . HOH D 3 .   ? 2.638   -31.853 -4.179  1.00 42.93  ? 467 HOH A O    1 
HETATM 3757 O O    . HOH D 3 .   ? 7.975   -24.014 -26.824 1.00 39.21  ? 468 HOH A O    1 
HETATM 3758 O O    . HOH D 3 .   ? 2.546   -14.059 -10.567 1.00 55.38  ? 469 HOH A O    1 
HETATM 3759 O O    . HOH D 3 .   ? 10.300  -18.860 -15.781 1.00 46.19  ? 470 HOH A O    1 
HETATM 3760 O O    . HOH D 3 .   ? -0.774  -35.657 -27.452 1.00 39.58  ? 471 HOH A O    1 
HETATM 3761 O O    . HOH D 3 .   ? 6.554   -28.033 -5.001  1.00 36.66  ? 472 HOH A O    1 
HETATM 3762 O O    . HOH D 3 .   ? 16.877  -20.153 -9.852  1.00 39.83  ? 473 HOH A O    1 
HETATM 3763 O O    . HOH D 3 .   ? 18.345  -28.088 -10.779 1.00 50.51  ? 474 HOH A O    1 
HETATM 3764 O O    . HOH D 3 .   ? 22.892  -12.757 -40.542 1.00 36.40  ? 475 HOH A O    1 
HETATM 3765 O O    . HOH D 3 .   ? 0.948   -33.044 -39.388 1.00 36.92  ? 476 HOH A O    1 
HETATM 3766 O O    . HOH D 3 .   ? -1.670  -29.626 -39.072 1.00 45.97  ? 477 HOH A O    1 
HETATM 3767 O O    . HOH D 3 .   ? 23.701  -13.740 -33.175 1.00 44.68  ? 478 HOH A O    1 
HETATM 3768 O O    . HOH D 3 .   ? 19.331  -11.035 -33.801 1.00 42.88  ? 479 HOH A O    1 
HETATM 3769 O O    . HOH D 3 .   ? 16.140  -12.031 -39.986 1.00 41.27  ? 480 HOH A O    1 
HETATM 3770 O O    . HOH D 3 .   ? 6.637   -16.511 -21.496 1.00 46.37  ? 481 HOH A O    1 
HETATM 3771 O O    . HOH D 3 .   ? 5.734   -10.287 -37.320 1.00 41.10  ? 482 HOH A O    1 
HETATM 3772 O O    . HOH D 3 .   ? 18.641  -11.698 -38.117 1.00 34.35  ? 483 HOH A O    1 
HETATM 3773 O O    . HOH E 3 .   ? -22.490 -16.938 -48.578 1.00 32.91  ? 301 HOH B O    1 
HETATM 3774 O O    . HOH E 3 .   ? -27.101 -17.618 -43.572 1.00 36.90  ? 302 HOH B O    1 
HETATM 3775 O O    . HOH E 3 .   ? -24.120 -30.935 -54.849 1.00 42.25  ? 303 HOH B O    1 
HETATM 3776 O O    . HOH E 3 .   ? -27.439 -19.872 -31.805 1.00 36.74  ? 304 HOH B O    1 
HETATM 3777 O O    . HOH E 3 .   ? -11.907 -18.722 -51.713 1.00 30.23  ? 305 HOH B O    1 
HETATM 3778 O O    . HOH E 3 .   ? -5.181  -26.680 -43.880 1.00 24.23  ? 306 HOH B O    1 
HETATM 3779 O O    . HOH E 3 .   ? -7.670  -38.360 -56.086 1.00 27.56  ? 307 HOH B O    1 
HETATM 3780 O O    . HOH E 3 .   ? -4.217  -38.923 -35.808 1.00 30.71  ? 308 HOH B O    1 
HETATM 3781 O O    . HOH E 3 .   ? -18.579 -44.642 -65.015 1.00 49.06  ? 309 HOH B O    1 
HETATM 3782 O O    . HOH E 3 .   ? -4.654  -16.591 -46.934 1.00 39.20  ? 310 HOH B O    1 
HETATM 3783 O O    . HOH E 3 .   ? -7.138  -45.203 -39.019 1.00 35.00  ? 311 HOH B O    1 
HETATM 3784 O O    . HOH E 3 .   ? -37.896 -30.899 -44.570 1.00 48.87  ? 312 HOH B O    1 
HETATM 3785 O O    . HOH E 3 .   ? -23.097 -27.998 -23.165 1.00 34.13  ? 313 HOH B O    1 
HETATM 3786 O O    . HOH E 3 .   ? -3.918  -22.002 -40.079 1.00 29.63  ? 314 HOH B O    1 
HETATM 3787 O O    . HOH E 3 .   ? -29.048 -19.737 -33.855 1.00 40.45  ? 315 HOH B O    1 
HETATM 3788 O O    . HOH E 3 .   ? -21.428 -35.705 -26.179 1.00 28.81  ? 316 HOH B O    1 
HETATM 3789 O O    . HOH E 3 .   ? -14.913 -13.708 -52.255 1.00 36.90  ? 317 HOH B O    1 
HETATM 3790 O O    . HOH E 3 .   ? -11.222 -18.203 -40.402 1.00 31.26  ? 318 HOH B O    1 
HETATM 3791 O O    . HOH E 3 .   ? -25.728 -21.542 -51.073 1.00 41.44  ? 319 HOH B O    1 
HETATM 3792 O O    . HOH E 3 .   ? -22.682 -44.261 -35.769 1.00 39.33  ? 320 HOH B O    1 
HETATM 3793 O O    . HOH E 3 .   ? -9.946  -40.223 -30.705 1.00 32.04  ? 321 HOH B O    1 
HETATM 3794 O O    . HOH E 3 .   ? -8.320  -21.317 -29.404 1.00 34.79  ? 322 HOH B O    1 
HETATM 3795 O O    . HOH E 3 .   ? -9.554  -13.169 -43.052 1.00 34.32  ? 323 HOH B O    1 
HETATM 3796 O O    . HOH E 3 .   ? -36.874 -34.968 -33.389 1.00 40.00  ? 324 HOH B O    1 
HETATM 3797 O O    . HOH E 3 .   ? -3.505  -28.546 -37.459 1.00 31.09  ? 325 HOH B O    1 
HETATM 3798 O O    . HOH E 3 .   ? -23.270 -42.872 -23.799 1.00 46.57  ? 326 HOH B O    1 
HETATM 3799 O O    . HOH E 3 .   ? -18.278 -46.558 -35.052 1.00 35.32  ? 327 HOH B O    1 
HETATM 3800 O O    . HOH E 3 .   ? -7.588  -27.997 -44.883 1.00 28.31  ? 328 HOH B O    1 
HETATM 3801 O O    . HOH E 3 .   ? -23.372 -10.432 -32.019 1.00 35.37  ? 329 HOH B O    1 
HETATM 3802 O O    . HOH E 3 .   ? -28.658 -29.202 -57.868 1.00 42.61  ? 330 HOH B O    1 
HETATM 3803 O O    . HOH E 3 .   ? -10.102 -44.624 -59.285 1.00 31.63  ? 331 HOH B O    1 
HETATM 3804 O O    . HOH E 3 .   ? -26.016 -9.195  -35.005 1.00 41.72  ? 332 HOH B O    1 
HETATM 3805 O O    . HOH E 3 .   ? -8.773  -31.649 -45.664 1.00 42.47  ? 333 HOH B O    1 
HETATM 3806 O O    . HOH E 3 .   ? -26.392 -19.422 -40.646 1.00 35.79  ? 334 HOH B O    1 
HETATM 3807 O O    . HOH E 3 .   ? -17.121 -37.746 -45.335 1.00 37.20  ? 335 HOH B O    1 
HETATM 3808 O O    . HOH E 3 .   ? -21.662 -40.371 -42.340 1.00 31.99  ? 336 HOH B O    1 
HETATM 3809 O O    . HOH E 3 .   ? -23.506 -21.931 -24.832 1.00 44.20  ? 337 HOH B O    1 
HETATM 3810 O O    . HOH E 3 .   ? -9.225  -33.957 -46.887 1.00 31.70  ? 338 HOH B O    1 
HETATM 3811 O O    . HOH E 3 .   ? -8.682  -48.745 -64.331 1.00 43.91  ? 339 HOH B O    1 
HETATM 3812 O O    . HOH E 3 .   ? -13.971 -25.847 -36.837 1.00 33.59  ? 340 HOH B O    1 
HETATM 3813 O O    . HOH E 3 .   ? -2.029  -29.831 -47.670 1.00 37.66  ? 341 HOH B O    1 
HETATM 3814 O O    . HOH E 3 .   ? -15.718 -31.122 -62.298 1.00 26.93  ? 342 HOH B O    1 
HETATM 3815 O O    . HOH E 3 .   ? -34.800 -24.012 -29.152 1.00 48.52  ? 343 HOH B O    1 
HETATM 3816 O O    . HOH E 3 .   ? -16.325 -48.756 -61.597 1.00 50.09  ? 344 HOH B O    1 
HETATM 3817 O O    . HOH E 3 .   ? -15.749 -30.912 -59.257 1.00 28.26  ? 345 HOH B O    1 
HETATM 3818 O O    . HOH E 3 .   ? -9.232  -51.137 -64.918 1.00 49.18  ? 346 HOH B O    1 
# 
