data_9GQT
# 
_entry.id   9GQT 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.404 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9GQT         pdb_00009gqt 10.2210/pdb9gqt/pdb 
WWPDB D_1292141408 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-06-11 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9GQT 
_pdbx_database_status.recvd_initial_deposition_date   2024-09-09 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 3 
_pdbx_contact_author.email              thomas.bowden@strubi.ox.ac.uk 
_pdbx_contact_author.name_first         Thomas 
_pdbx_contact_author.name_last          Bowden 
_pdbx_contact_author.name_mi            A. 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-8066-8785 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Bowden, T.A.' 1 ? 
'Paesen, G.C.' 2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Elife 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2050-084X 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Structure-Guided Loop Grafting Improves Expression and Stability of Influenza Neuraminidase for Vaccine Development' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.7554/elife.105317.2 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Rijal, P.'      1 ? 
primary 'Wei, L.'        2 ? 
primary 'Paesen, G.C.'   3 ? 
primary 'Stuart, D.I.'   4 ? 
primary 'Howarth, M.R.'  5 ? 
primary 'Huang, K.Y.A.'  6 ? 
primary 'Bowden, T.A.'   7 ? 
primary 'Townsend, A.R.' 8 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man Neuraminidase                                                                             55640.086 2   3.2.1.18 
? ? ? 
2 branched    man '2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose' 424.401   1   ?        
? ? ? 
3 non-polymer syn 'CALCIUM ION'                                                                             40.078    4   ?        
? ? ? 
4 non-polymer syn 2-acetamido-2-deoxy-beta-D-glucopyranose                                                  221.208   5   ?        
? ? ? 
5 water       nat water                                                                                     18.015    695 ?        
? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MNTQILVFALIAIIPTNADKISAWSHPQFEKGGGGSHHHHHHSSSGSGAHIVMVDAYKPTKGGSGGGGSIINETADDIVY
RLTVIIDDRYESLKNLITLRADRLEMIINDNVSTILAGGSGTGSVTLAGNSSLCPISGWAIYSKDNGIRIGSKGDVFVIR
EPFISCSHLECRTFFLTQGALLNDKHSNGTIKDRSPYRTLMSCPVGEAPSPYNSRFESVAWSASACHDGISWLTIGISGP
DNGAVAVVKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQASYKIFKIEKGKVVKSVEMNAPNYHYEE
CSCYPDAGDIMCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGIFGDNPRPNDKTGSCGPVSSNGANGVKGFSFKYGNGVW
IGRTKSISSRNGFEMIWDPNGWTETDSSFSVKQDIVGINEWSGYSGSFVQHPEMTGLDCMRPCFWVELIRGRPKENTIWT
SGSSISFCGVNSDTVGWSWPDGAELPFTIDK
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MNTQILVFALIAIIPTNADKISAWSHPQFEKGGGGSHHHHHHSSSGSGAHIVMVDAYKPTKGGSGGGGSIINETADDIVY
RLTVIIDDRYESLKNLITLRADRLEMIINDNVSTILAGGSGTGSVTLAGNSSLCPISGWAIYSKDNGIRIGSKGDVFVIR
EPFISCSHLECRTFFLTQGALLNDKHSNGTIKDRSPYRTLMSCPVGEAPSPYNSRFESVAWSASACHDGISWLTIGISGP
DNGAVAVVKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQASYKIFKIEKGKVVKSVEMNAPNYHYEE
CSCYPDAGDIMCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGIFGDNPRPNDKTGSCGPVSSNGANGVKGFSFKYGNGVW
IGRTKSISSRNGFEMIWDPNGWTETDSSFSVKQDIVGINEWSGYSGSFVQHPEMTGLDCMRPCFWVELIRGRPKENTIWT
SGSSISFCGVNSDTVGWSWPDGAELPFTIDK
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
3 'CALCIUM ION'                            CA  
4 2-acetamido-2-deoxy-beta-D-glucopyranose NAG 
5 water                                    HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ASN n 
1 3   THR n 
1 4   GLN n 
1 5   ILE n 
1 6   LEU n 
1 7   VAL n 
1 8   PHE n 
1 9   ALA n 
1 10  LEU n 
1 11  ILE n 
1 12  ALA n 
1 13  ILE n 
1 14  ILE n 
1 15  PRO n 
1 16  THR n 
1 17  ASN n 
1 18  ALA n 
1 19  ASP n 
1 20  LYS n 
1 21  ILE n 
1 22  SER n 
1 23  ALA n 
1 24  TRP n 
1 25  SER n 
1 26  HIS n 
1 27  PRO n 
1 28  GLN n 
1 29  PHE n 
1 30  GLU n 
1 31  LYS n 
1 32  GLY n 
1 33  GLY n 
1 34  GLY n 
1 35  GLY n 
1 36  SER n 
1 37  HIS n 
1 38  HIS n 
1 39  HIS n 
1 40  HIS n 
1 41  HIS n 
1 42  HIS n 
1 43  SER n 
1 44  SER n 
1 45  SER n 
1 46  GLY n 
1 47  SER n 
1 48  GLY n 
1 49  ALA n 
1 50  HIS n 
1 51  ILE n 
1 52  VAL n 
1 53  MET n 
1 54  VAL n 
1 55  ASP n 
1 56  ALA n 
1 57  TYR n 
1 58  LYS n 
1 59  PRO n 
1 60  THR n 
1 61  LYS n 
1 62  GLY n 
1 63  GLY n 
1 64  SER n 
1 65  GLY n 
1 66  GLY n 
1 67  GLY n 
1 68  GLY n 
1 69  SER n 
1 70  ILE n 
1 71  ILE n 
1 72  ASN n 
1 73  GLU n 
1 74  THR n 
1 75  ALA n 
1 76  ASP n 
1 77  ASP n 
1 78  ILE n 
1 79  VAL n 
1 80  TYR n 
1 81  ARG n 
1 82  LEU n 
1 83  THR n 
1 84  VAL n 
1 85  ILE n 
1 86  ILE n 
1 87  ASP n 
1 88  ASP n 
1 89  ARG n 
1 90  TYR n 
1 91  GLU n 
1 92  SER n 
1 93  LEU n 
1 94  LYS n 
1 95  ASN n 
1 96  LEU n 
1 97  ILE n 
1 98  THR n 
1 99  LEU n 
1 100 ARG n 
1 101 ALA n 
1 102 ASP n 
1 103 ARG n 
1 104 LEU n 
1 105 GLU n 
1 106 MET n 
1 107 ILE n 
1 108 ILE n 
1 109 ASN n 
1 110 ASP n 
1 111 ASN n 
1 112 VAL n 
1 113 SER n 
1 114 THR n 
1 115 ILE n 
1 116 LEU n 
1 117 ALA n 
1 118 GLY n 
1 119 GLY n 
1 120 SER n 
1 121 GLY n 
1 122 THR n 
1 123 GLY n 
1 124 SER n 
1 125 VAL n 
1 126 THR n 
1 127 LEU n 
1 128 ALA n 
1 129 GLY n 
1 130 ASN n 
1 131 SER n 
1 132 SER n 
1 133 LEU n 
1 134 CYS n 
1 135 PRO n 
1 136 ILE n 
1 137 SER n 
1 138 GLY n 
1 139 TRP n 
1 140 ALA n 
1 141 ILE n 
1 142 TYR n 
1 143 SER n 
1 144 LYS n 
1 145 ASP n 
1 146 ASN n 
1 147 GLY n 
1 148 ILE n 
1 149 ARG n 
1 150 ILE n 
1 151 GLY n 
1 152 SER n 
1 153 LYS n 
1 154 GLY n 
1 155 ASP n 
1 156 VAL n 
1 157 PHE n 
1 158 VAL n 
1 159 ILE n 
1 160 ARG n 
1 161 GLU n 
1 162 PRO n 
1 163 PHE n 
1 164 ILE n 
1 165 SER n 
1 166 CYS n 
1 167 SER n 
1 168 HIS n 
1 169 LEU n 
1 170 GLU n 
1 171 CYS n 
1 172 ARG n 
1 173 THR n 
1 174 PHE n 
1 175 PHE n 
1 176 LEU n 
1 177 THR n 
1 178 GLN n 
1 179 GLY n 
1 180 ALA n 
1 181 LEU n 
1 182 LEU n 
1 183 ASN n 
1 184 ASP n 
1 185 LYS n 
1 186 HIS n 
1 187 SER n 
1 188 ASN n 
1 189 GLY n 
1 190 THR n 
1 191 ILE n 
1 192 LYS n 
1 193 ASP n 
1 194 ARG n 
1 195 SER n 
1 196 PRO n 
1 197 TYR n 
1 198 ARG n 
1 199 THR n 
1 200 LEU n 
1 201 MET n 
1 202 SER n 
1 203 CYS n 
1 204 PRO n 
1 205 VAL n 
1 206 GLY n 
1 207 GLU n 
1 208 ALA n 
1 209 PRO n 
1 210 SER n 
1 211 PRO n 
1 212 TYR n 
1 213 ASN n 
1 214 SER n 
1 215 ARG n 
1 216 PHE n 
1 217 GLU n 
1 218 SER n 
1 219 VAL n 
1 220 ALA n 
1 221 TRP n 
1 222 SER n 
1 223 ALA n 
1 224 SER n 
1 225 ALA n 
1 226 CYS n 
1 227 HIS n 
1 228 ASP n 
1 229 GLY n 
1 230 ILE n 
1 231 SER n 
1 232 TRP n 
1 233 LEU n 
1 234 THR n 
1 235 ILE n 
1 236 GLY n 
1 237 ILE n 
1 238 SER n 
1 239 GLY n 
1 240 PRO n 
1 241 ASP n 
1 242 ASN n 
1 243 GLY n 
1 244 ALA n 
1 245 VAL n 
1 246 ALA n 
1 247 VAL n 
1 248 VAL n 
1 249 LYS n 
1 250 TYR n 
1 251 ASN n 
1 252 GLY n 
1 253 ILE n 
1 254 ILE n 
1 255 THR n 
1 256 ASP n 
1 257 THR n 
1 258 ILE n 
1 259 LYS n 
1 260 SER n 
1 261 TRP n 
1 262 ARG n 
1 263 ASN n 
1 264 ASN n 
1 265 ILE n 
1 266 LEU n 
1 267 ARG n 
1 268 THR n 
1 269 GLN n 
1 270 GLU n 
1 271 SER n 
1 272 GLU n 
1 273 CYS n 
1 274 ALA n 
1 275 CYS n 
1 276 VAL n 
1 277 ASN n 
1 278 GLY n 
1 279 SER n 
1 280 CYS n 
1 281 PHE n 
1 282 THR n 
1 283 VAL n 
1 284 MET n 
1 285 THR n 
1 286 ASP n 
1 287 GLY n 
1 288 PRO n 
1 289 SER n 
1 290 ASN n 
1 291 GLY n 
1 292 GLN n 
1 293 ALA n 
1 294 SER n 
1 295 TYR n 
1 296 LYS n 
1 297 ILE n 
1 298 PHE n 
1 299 LYS n 
1 300 ILE n 
1 301 GLU n 
1 302 LYS n 
1 303 GLY n 
1 304 LYS n 
1 305 VAL n 
1 306 VAL n 
1 307 LYS n 
1 308 SER n 
1 309 VAL n 
1 310 GLU n 
1 311 MET n 
1 312 ASN n 
1 313 ALA n 
1 314 PRO n 
1 315 ASN n 
1 316 TYR n 
1 317 HIS n 
1 318 TYR n 
1 319 GLU n 
1 320 GLU n 
1 321 CYS n 
1 322 SER n 
1 323 CYS n 
1 324 TYR n 
1 325 PRO n 
1 326 ASP n 
1 327 ALA n 
1 328 GLY n 
1 329 ASP n 
1 330 ILE n 
1 331 MET n 
1 332 CYS n 
1 333 VAL n 
1 334 CYS n 
1 335 ARG n 
1 336 ASP n 
1 337 ASN n 
1 338 TRP n 
1 339 HIS n 
1 340 GLY n 
1 341 SER n 
1 342 ASN n 
1 343 ARG n 
1 344 PRO n 
1 345 TRP n 
1 346 VAL n 
1 347 SER n 
1 348 PHE n 
1 349 ASN n 
1 350 GLN n 
1 351 ASN n 
1 352 LEU n 
1 353 GLU n 
1 354 TYR n 
1 355 GLN n 
1 356 ILE n 
1 357 GLY n 
1 358 TYR n 
1 359 ILE n 
1 360 CYS n 
1 361 SER n 
1 362 GLY n 
1 363 ILE n 
1 364 PHE n 
1 365 GLY n 
1 366 ASP n 
1 367 ASN n 
1 368 PRO n 
1 369 ARG n 
1 370 PRO n 
1 371 ASN n 
1 372 ASP n 
1 373 LYS n 
1 374 THR n 
1 375 GLY n 
1 376 SER n 
1 377 CYS n 
1 378 GLY n 
1 379 PRO n 
1 380 VAL n 
1 381 SER n 
1 382 SER n 
1 383 ASN n 
1 384 GLY n 
1 385 ALA n 
1 386 ASN n 
1 387 GLY n 
1 388 VAL n 
1 389 LYS n 
1 390 GLY n 
1 391 PHE n 
1 392 SER n 
1 393 PHE n 
1 394 LYS n 
1 395 TYR n 
1 396 GLY n 
1 397 ASN n 
1 398 GLY n 
1 399 VAL n 
1 400 TRP n 
1 401 ILE n 
1 402 GLY n 
1 403 ARG n 
1 404 THR n 
1 405 LYS n 
1 406 SER n 
1 407 ILE n 
1 408 SER n 
1 409 SER n 
1 410 ARG n 
1 411 ASN n 
1 412 GLY n 
1 413 PHE n 
1 414 GLU n 
1 415 MET n 
1 416 ILE n 
1 417 TRP n 
1 418 ASP n 
1 419 PRO n 
1 420 ASN n 
1 421 GLY n 
1 422 TRP n 
1 423 THR n 
1 424 GLU n 
1 425 THR n 
1 426 ASP n 
1 427 SER n 
1 428 SER n 
1 429 PHE n 
1 430 SER n 
1 431 VAL n 
1 432 LYS n 
1 433 GLN n 
1 434 ASP n 
1 435 ILE n 
1 436 VAL n 
1 437 GLY n 
1 438 ILE n 
1 439 ASN n 
1 440 GLU n 
1 441 TRP n 
1 442 SER n 
1 443 GLY n 
1 444 TYR n 
1 445 SER n 
1 446 GLY n 
1 447 SER n 
1 448 PHE n 
1 449 VAL n 
1 450 GLN n 
1 451 HIS n 
1 452 PRO n 
1 453 GLU n 
1 454 MET n 
1 455 THR n 
1 456 GLY n 
1 457 LEU n 
1 458 ASP n 
1 459 CYS n 
1 460 MET n 
1 461 ARG n 
1 462 PRO n 
1 463 CYS n 
1 464 PHE n 
1 465 TRP n 
1 466 VAL n 
1 467 GLU n 
1 468 LEU n 
1 469 ILE n 
1 470 ARG n 
1 471 GLY n 
1 472 ARG n 
1 473 PRO n 
1 474 LYS n 
1 475 GLU n 
1 476 ASN n 
1 477 THR n 
1 478 ILE n 
1 479 TRP n 
1 480 THR n 
1 481 SER n 
1 482 GLY n 
1 483 SER n 
1 484 SER n 
1 485 ILE n 
1 486 SER n 
1 487 PHE n 
1 488 CYS n 
1 489 GLY n 
1 490 VAL n 
1 491 ASN n 
1 492 SER n 
1 493 ASP n 
1 494 THR n 
1 495 VAL n 
1 496 GLY n 
1 497 TRP n 
1 498 SER n 
1 499 TRP n 
1 500 PRO n 
1 501 ASP n 
1 502 GLY n 
1 503 ALA n 
1 504 GLU n 
1 505 LEU n 
1 506 PRO n 
1 507 PHE n 
1 508 THR n 
1 509 ILE n 
1 510 ASP n 
1 511 LYS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   511 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 NA 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'unidentified influenza virus' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     11309 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Cricetulus griseus' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     10029 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
_pdbx_entity_branch.entity_id   2 
_pdbx_entity_branch.type        oligosaccharide 
# 
loop_
_pdbx_entity_branch_descriptor.ordinal 
_pdbx_entity_branch_descriptor.entity_id 
_pdbx_entity_branch_descriptor.descriptor 
_pdbx_entity_branch_descriptor.type 
_pdbx_entity_branch_descriptor.program 
_pdbx_entity_branch_descriptor.program_version 
1 2 DGlcpNAcb1-4DGlcpNAcb1-ROH                            'Glycam Condensed Sequence' GMML       1.0   
2 2 'WURCS=2.0/1,2,1/[a2122h-1b_1-5_2*NCC/3=O]/1-1/a4-b1' WURCS                       PDB2Glycan 1.1.0 
3 2 '[][D-1-deoxy-GlcpNAc]{[(4+1)][b-D-GlcpNAc]{}}'       LINUCS                      PDB-CARE   ?     
# 
_pdbx_entity_branch_link.link_id                    1 
_pdbx_entity_branch_link.entity_id                  2 
_pdbx_entity_branch_link.entity_branch_list_num_1   2 
_pdbx_entity_branch_link.comp_id_1                  NAG 
_pdbx_entity_branch_link.atom_id_1                  C1 
_pdbx_entity_branch_link.leaving_atom_id_1          O1 
_pdbx_entity_branch_link.entity_branch_list_num_2   1 
_pdbx_entity_branch_link.comp_id_2                  NAG 
_pdbx_entity_branch_link.atom_id_2                  O4 
_pdbx_entity_branch_link.leaving_atom_id_2          HO4 
_pdbx_entity_branch_link.value_order                sing 
_pdbx_entity_branch_link.details                    ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking'          y ALANINE                                  ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking'          y ARGININE                                 ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking'          y ASPARAGINE                               ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking'          y 'ASPARTIC ACID'                          ? 'C4 H7 N O4'     133.103 
CA  non-polymer                  . 'CALCIUM ION'                            ? 'Ca 2'           40.078  
CYS 'L-peptide linking'          y CYSTEINE                                 ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking'          y GLUTAMINE                                ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking'          y 'GLUTAMIC ACID'                          ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'            y GLYCINE                                  ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking'          y HISTIDINE                                ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer                  . WATER                                    ? 'H2 O'           18.015  
ILE 'L-peptide linking'          y ISOLEUCINE                               ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking'          y LEUCINE                                  ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking'          y LYSINE                                   ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking'          y METHIONINE                               ? 'C5 H11 N O2 S'  149.211 
NAG 'D-saccharide, beta linking' . 2-acetamido-2-deoxy-beta-D-glucopyranose 
;N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE
;
'C8 H15 N O6'    221.208 
PHE 'L-peptide linking'          y PHENYLALANINE                            ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking'          y PROLINE                                  ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking'          y SERINE                                   ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking'          y THREONINE                                ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking'          y TRYPTOPHAN                               ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking'          y TYROSINE                                 ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking'          y VALINE                                   ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_chem_comp_identifier.comp_id 
_pdbx_chem_comp_identifier.type 
_pdbx_chem_comp_identifier.program 
_pdbx_chem_comp_identifier.program_version 
_pdbx_chem_comp_identifier.identifier 
NAG 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DGlcpNAcb                      
NAG 'COMMON NAME'                         GMML     1.0 N-acetyl-b-D-glucopyranosamine 
NAG 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 b-D-GlcpNAc                    
NAG 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 GlcNAc                         
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   -41 ?   ?   ?   A . n 
A 1 2   ASN 2   -40 ?   ?   ?   A . n 
A 1 3   THR 3   -39 ?   ?   ?   A . n 
A 1 4   GLN 4   -38 ?   ?   ?   A . n 
A 1 5   ILE 5   -37 ?   ?   ?   A . n 
A 1 6   LEU 6   -36 ?   ?   ?   A . n 
A 1 7   VAL 7   -35 ?   ?   ?   A . n 
A 1 8   PHE 8   -34 ?   ?   ?   A . n 
A 1 9   ALA 9   -33 ?   ?   ?   A . n 
A 1 10  LEU 10  -32 ?   ?   ?   A . n 
A 1 11  ILE 11  -31 ?   ?   ?   A . n 
A 1 12  ALA 12  -30 ?   ?   ?   A . n 
A 1 13  ILE 13  -29 ?   ?   ?   A . n 
A 1 14  ILE 14  -28 ?   ?   ?   A . n 
A 1 15  PRO 15  -27 ?   ?   ?   A . n 
A 1 16  THR 16  -26 ?   ?   ?   A . n 
A 1 17  ASN 17  -25 ?   ?   ?   A . n 
A 1 18  ALA 18  -24 ?   ?   ?   A . n 
A 1 19  ASP 19  -23 ?   ?   ?   A . n 
A 1 20  LYS 20  -22 ?   ?   ?   A . n 
A 1 21  ILE 21  -21 ?   ?   ?   A . n 
A 1 22  SER 22  -20 ?   ?   ?   A . n 
A 1 23  ALA 23  -19 ?   ?   ?   A . n 
A 1 24  TRP 24  -18 ?   ?   ?   A . n 
A 1 25  SER 25  -17 ?   ?   ?   A . n 
A 1 26  HIS 26  -16 ?   ?   ?   A . n 
A 1 27  PRO 27  -15 ?   ?   ?   A . n 
A 1 28  GLN 28  -14 ?   ?   ?   A . n 
A 1 29  PHE 29  -13 ?   ?   ?   A . n 
A 1 30  GLU 30  -12 ?   ?   ?   A . n 
A 1 31  LYS 31  -11 ?   ?   ?   A . n 
A 1 32  GLY 32  -10 ?   ?   ?   A . n 
A 1 33  GLY 33  -9  ?   ?   ?   A . n 
A 1 34  GLY 34  -8  ?   ?   ?   A . n 
A 1 35  GLY 35  -7  ?   ?   ?   A . n 
A 1 36  SER 36  -6  ?   ?   ?   A . n 
A 1 37  HIS 37  -5  ?   ?   ?   A . n 
A 1 38  HIS 38  -4  ?   ?   ?   A . n 
A 1 39  HIS 39  -3  ?   ?   ?   A . n 
A 1 40  HIS 40  -2  ?   ?   ?   A . n 
A 1 41  HIS 41  -1  ?   ?   ?   A . n 
A 1 42  HIS 42  0   ?   ?   ?   A . n 
A 1 43  SER 43  1   ?   ?   ?   A . n 
A 1 44  SER 44  2   ?   ?   ?   A . n 
A 1 45  SER 45  3   ?   ?   ?   A . n 
A 1 46  GLY 46  4   ?   ?   ?   A . n 
A 1 47  SER 47  5   ?   ?   ?   A . n 
A 1 48  GLY 48  6   ?   ?   ?   A . n 
A 1 49  ALA 49  7   ?   ?   ?   A . n 
A 1 50  HIS 50  8   ?   ?   ?   A . n 
A 1 51  ILE 51  9   ?   ?   ?   A . n 
A 1 52  VAL 52  10  ?   ?   ?   A . n 
A 1 53  MET 53  11  ?   ?   ?   A . n 
A 1 54  VAL 54  12  ?   ?   ?   A . n 
A 1 55  ASP 55  13  ?   ?   ?   A . n 
A 1 56  ALA 56  14  ?   ?   ?   A . n 
A 1 57  TYR 57  15  ?   ?   ?   A . n 
A 1 58  LYS 58  16  ?   ?   ?   A . n 
A 1 59  PRO 59  17  ?   ?   ?   A . n 
A 1 60  THR 60  18  ?   ?   ?   A . n 
A 1 61  LYS 61  19  ?   ?   ?   A . n 
A 1 62  GLY 62  20  ?   ?   ?   A . n 
A 1 63  GLY 63  21  ?   ?   ?   A . n 
A 1 64  SER 64  22  ?   ?   ?   A . n 
A 1 65  GLY 65  23  ?   ?   ?   A . n 
A 1 66  GLY 66  24  ?   ?   ?   A . n 
A 1 67  GLY 67  25  ?   ?   ?   A . n 
A 1 68  GLY 68  26  ?   ?   ?   A . n 
A 1 69  SER 69  27  ?   ?   ?   A . n 
A 1 70  ILE 70  28  ?   ?   ?   A . n 
A 1 71  ILE 71  29  ?   ?   ?   A . n 
A 1 72  ASN 72  30  ?   ?   ?   A . n 
A 1 73  GLU 73  31  ?   ?   ?   A . n 
A 1 74  THR 74  32  ?   ?   ?   A . n 
A 1 75  ALA 75  33  ?   ?   ?   A . n 
A 1 76  ASP 76  34  ?   ?   ?   A . n 
A 1 77  ASP 77  35  ?   ?   ?   A . n 
A 1 78  ILE 78  36  ?   ?   ?   A . n 
A 1 79  VAL 79  37  ?   ?   ?   A . n 
A 1 80  TYR 80  38  ?   ?   ?   A . n 
A 1 81  ARG 81  39  ?   ?   ?   A . n 
A 1 82  LEU 82  40  ?   ?   ?   A . n 
A 1 83  THR 83  41  ?   ?   ?   A . n 
A 1 84  VAL 84  42  ?   ?   ?   A . n 
A 1 85  ILE 85  43  ?   ?   ?   A . n 
A 1 86  ILE 86  44  ?   ?   ?   A . n 
A 1 87  ASP 87  45  ?   ?   ?   A . n 
A 1 88  ASP 88  46  ?   ?   ?   A . n 
A 1 89  ARG 89  47  ?   ?   ?   A . n 
A 1 90  TYR 90  48  ?   ?   ?   A . n 
A 1 91  GLU 91  49  ?   ?   ?   A . n 
A 1 92  SER 92  50  ?   ?   ?   A . n 
A 1 93  LEU 93  51  ?   ?   ?   A . n 
A 1 94  LYS 94  52  ?   ?   ?   A . n 
A 1 95  ASN 95  53  ?   ?   ?   A . n 
A 1 96  LEU 96  54  ?   ?   ?   A . n 
A 1 97  ILE 97  55  55  ILE ILE A . n 
A 1 98  THR 98  56  56  THR THR A . n 
A 1 99  LEU 99  57  57  LEU LEU A . n 
A 1 100 ARG 100 58  58  ARG ARG A . n 
A 1 101 ALA 101 59  59  ALA ALA A . n 
A 1 102 ASP 102 60  60  ASP ASP A . n 
A 1 103 ARG 103 61  61  ARG ARG A . n 
A 1 104 LEU 104 62  62  LEU LEU A . n 
A 1 105 GLU 105 63  63  GLU GLU A . n 
A 1 106 MET 106 64  64  MET MET A . n 
A 1 107 ILE 107 65  65  ILE ILE A . n 
A 1 108 ILE 108 66  66  ILE ILE A . n 
A 1 109 ASN 109 67  67  ASN ASN A . n 
A 1 110 ASP 110 68  68  ASP ASP A . n 
A 1 111 ASN 111 69  69  ASN ASN A . n 
A 1 112 VAL 112 70  70  VAL VAL A . n 
A 1 113 SER 113 71  71  SER SER A . n 
A 1 114 THR 114 72  72  THR THR A . n 
A 1 115 ILE 115 73  73  ILE ILE A . n 
A 1 116 LEU 116 74  74  LEU LEU A . n 
A 1 117 ALA 117 75  75  ALA ALA A . n 
A 1 118 GLY 118 76  76  GLY GLY A . n 
A 1 119 GLY 119 77  77  GLY GLY A . n 
A 1 120 SER 120 78  78  SER SER A . n 
A 1 121 GLY 121 79  79  GLY GLY A . n 
A 1 122 THR 122 80  80  THR THR A . n 
A 1 123 GLY 123 81  81  GLY GLY A . n 
A 1 124 SER 124 82  82  SER SER A . n 
A 1 125 VAL 125 83  83  VAL VAL A . n 
A 1 126 THR 126 84  84  THR THR A . n 
A 1 127 LEU 127 85  85  LEU LEU A . n 
A 1 128 ALA 128 86  86  ALA ALA A . n 
A 1 129 GLY 129 87  87  GLY GLY A . n 
A 1 130 ASN 130 88  88  ASN ASN A . n 
A 1 131 SER 131 89  89  SER SER A . n 
A 1 132 SER 132 90  90  SER SER A . n 
A 1 133 LEU 133 91  91  LEU LEU A . n 
A 1 134 CYS 134 92  92  CYS CYS A . n 
A 1 135 PRO 135 93  93  PRO PRO A . n 
A 1 136 ILE 136 94  94  ILE ILE A . n 
A 1 137 SER 137 95  95  SER SER A . n 
A 1 138 GLY 138 96  96  GLY GLY A . n 
A 1 139 TRP 139 97  97  TRP TRP A . n 
A 1 140 ALA 140 98  98  ALA ALA A . n 
A 1 141 ILE 141 99  99  ILE ILE A . n 
A 1 142 TYR 142 100 100 TYR TYR A . n 
A 1 143 SER 143 101 101 SER SER A . n 
A 1 144 LYS 144 102 102 LYS LYS A . n 
A 1 145 ASP 145 103 103 ASP ASP A . n 
A 1 146 ASN 146 104 104 ASN ASN A . n 
A 1 147 GLY 147 105 105 GLY GLY A . n 
A 1 148 ILE 148 106 106 ILE ILE A . n 
A 1 149 ARG 149 107 107 ARG ARG A . n 
A 1 150 ILE 150 108 108 ILE ILE A . n 
A 1 151 GLY 151 109 109 GLY GLY A . n 
A 1 152 SER 152 110 110 SER SER A . n 
A 1 153 LYS 153 111 111 LYS LYS A . n 
A 1 154 GLY 154 112 112 GLY GLY A . n 
A 1 155 ASP 155 113 113 ASP ASP A . n 
A 1 156 VAL 156 114 114 VAL VAL A . n 
A 1 157 PHE 157 115 115 PHE PHE A . n 
A 1 158 VAL 158 116 116 VAL VAL A . n 
A 1 159 ILE 159 117 117 ILE ILE A . n 
A 1 160 ARG 160 118 118 ARG ARG A . n 
A 1 161 GLU 161 119 119 GLU GLU A . n 
A 1 162 PRO 162 120 120 PRO PRO A . n 
A 1 163 PHE 163 121 121 PHE PHE A . n 
A 1 164 ILE 164 122 122 ILE ILE A . n 
A 1 165 SER 165 123 123 SER SER A . n 
A 1 166 CYS 166 124 124 CYS CYS A . n 
A 1 167 SER 167 125 125 SER SER A . n 
A 1 168 HIS 168 126 126 HIS HIS A . n 
A 1 169 LEU 169 127 127 LEU LEU A . n 
A 1 170 GLU 170 128 128 GLU GLU A . n 
A 1 171 CYS 171 129 129 CYS CYS A . n 
A 1 172 ARG 172 130 130 ARG ARG A . n 
A 1 173 THR 173 131 131 THR THR A . n 
A 1 174 PHE 174 132 132 PHE PHE A . n 
A 1 175 PHE 175 133 133 PHE PHE A . n 
A 1 176 LEU 176 134 134 LEU LEU A . n 
A 1 177 THR 177 135 135 THR THR A . n 
A 1 178 GLN 178 136 136 GLN GLN A . n 
A 1 179 GLY 179 137 137 GLY GLY A . n 
A 1 180 ALA 180 138 138 ALA ALA A . n 
A 1 181 LEU 181 139 139 LEU LEU A . n 
A 1 182 LEU 182 140 140 LEU LEU A . n 
A 1 183 ASN 183 141 141 ASN ASN A . n 
A 1 184 ASP 184 142 142 ASP ASP A . n 
A 1 185 LYS 185 143 143 LYS LYS A . n 
A 1 186 HIS 186 144 144 HIS HIS A . n 
A 1 187 SER 187 145 145 SER SER A . n 
A 1 188 ASN 188 146 146 ASN ASN A . n 
A 1 189 GLY 189 147 147 GLY GLY A . n 
A 1 190 THR 190 148 148 THR THR A . n 
A 1 191 ILE 191 149 149 ILE ILE A . n 
A 1 192 LYS 192 150 150 LYS LYS A . n 
A 1 193 ASP 193 151 151 ASP ASP A . n 
A 1 194 ARG 194 152 152 ARG ARG A . n 
A 1 195 SER 195 153 153 SER SER A . n 
A 1 196 PRO 196 154 154 PRO PRO A . n 
A 1 197 TYR 197 155 155 TYR TYR A . n 
A 1 198 ARG 198 156 156 ARG ARG A . n 
A 1 199 THR 199 157 157 THR THR A . n 
A 1 200 LEU 200 158 158 LEU LEU A . n 
A 1 201 MET 201 159 159 MET MET A . n 
A 1 202 SER 202 160 160 SER SER A . n 
A 1 203 CYS 203 161 161 CYS CYS A . n 
A 1 204 PRO 204 162 162 PRO PRO A . n 
A 1 205 VAL 205 163 163 VAL VAL A . n 
A 1 206 GLY 206 164 164 GLY GLY A . n 
A 1 207 GLU 207 165 165 GLU GLU A . n 
A 1 208 ALA 208 166 166 ALA ALA A . n 
A 1 209 PRO 209 167 167 PRO PRO A . n 
A 1 210 SER 210 168 168 SER SER A . n 
A 1 211 PRO 211 169 169 PRO PRO A . n 
A 1 212 TYR 212 170 170 TYR TYR A . n 
A 1 213 ASN 213 171 171 ASN ASN A . n 
A 1 214 SER 214 172 172 SER SER A . n 
A 1 215 ARG 215 173 173 ARG ARG A . n 
A 1 216 PHE 216 174 174 PHE PHE A . n 
A 1 217 GLU 217 175 175 GLU GLU A . n 
A 1 218 SER 218 176 176 SER SER A . n 
A 1 219 VAL 219 177 177 VAL VAL A . n 
A 1 220 ALA 220 178 178 ALA ALA A . n 
A 1 221 TRP 221 179 179 TRP TRP A . n 
A 1 222 SER 222 180 180 SER SER A . n 
A 1 223 ALA 223 181 181 ALA ALA A . n 
A 1 224 SER 224 182 182 SER SER A . n 
A 1 225 ALA 225 183 183 ALA ALA A . n 
A 1 226 CYS 226 184 184 CYS CYS A . n 
A 1 227 HIS 227 185 185 HIS HIS A . n 
A 1 228 ASP 228 186 186 ASP ASP A . n 
A 1 229 GLY 229 187 187 GLY GLY A . n 
A 1 230 ILE 230 188 188 ILE ILE A . n 
A 1 231 SER 231 189 189 SER SER A . n 
A 1 232 TRP 232 190 190 TRP TRP A . n 
A 1 233 LEU 233 191 191 LEU LEU A . n 
A 1 234 THR 234 192 192 THR THR A . n 
A 1 235 ILE 235 193 193 ILE ILE A . n 
A 1 236 GLY 236 194 194 GLY GLY A . n 
A 1 237 ILE 237 195 195 ILE ILE A . n 
A 1 238 SER 238 196 196 SER SER A . n 
A 1 239 GLY 239 197 197 GLY GLY A . n 
A 1 240 PRO 240 198 198 PRO PRO A . n 
A 1 241 ASP 241 199 199 ASP ASP A . n 
A 1 242 ASN 242 200 200 ASN ASN A . n 
A 1 243 GLY 243 201 201 GLY GLY A . n 
A 1 244 ALA 244 202 202 ALA ALA A . n 
A 1 245 VAL 245 203 203 VAL VAL A . n 
A 1 246 ALA 246 204 204 ALA ALA A . n 
A 1 247 VAL 247 205 205 VAL VAL A . n 
A 1 248 VAL 248 206 206 VAL VAL A . n 
A 1 249 LYS 249 207 207 LYS LYS A . n 
A 1 250 TYR 250 208 208 TYR TYR A . n 
A 1 251 ASN 251 209 209 ASN ASN A . n 
A 1 252 GLY 252 210 210 GLY GLY A . n 
A 1 253 ILE 253 211 211 ILE ILE A . n 
A 1 254 ILE 254 212 212 ILE ILE A . n 
A 1 255 THR 255 213 213 THR THR A . n 
A 1 256 ASP 256 214 214 ASP ASP A . n 
A 1 257 THR 257 215 215 THR THR A . n 
A 1 258 ILE 258 216 216 ILE ILE A . n 
A 1 259 LYS 259 217 217 LYS LYS A . n 
A 1 260 SER 260 218 218 SER SER A . n 
A 1 261 TRP 261 219 219 TRP TRP A . n 
A 1 262 ARG 262 220 220 ARG ARG A . n 
A 1 263 ASN 263 221 221 ASN ASN A . n 
A 1 264 ASN 264 222 222 ASN ASN A . n 
A 1 265 ILE 265 223 223 ILE ILE A . n 
A 1 266 LEU 266 224 224 LEU LEU A . n 
A 1 267 ARG 267 225 225 ARG ARG A . n 
A 1 268 THR 268 226 226 THR THR A . n 
A 1 269 GLN 269 227 227 GLN GLN A . n 
A 1 270 GLU 270 228 228 GLU GLU A . n 
A 1 271 SER 271 229 229 SER SER A . n 
A 1 272 GLU 272 230 230 GLU GLU A . n 
A 1 273 CYS 273 231 231 CYS CYS A . n 
A 1 274 ALA 274 232 232 ALA ALA A . n 
A 1 275 CYS 275 233 233 CYS CYS A . n 
A 1 276 VAL 276 234 234 VAL VAL A . n 
A 1 277 ASN 277 235 235 ASN ASN A . n 
A 1 278 GLY 278 236 236 GLY GLY A . n 
A 1 279 SER 279 237 237 SER SER A . n 
A 1 280 CYS 280 238 238 CYS CYS A . n 
A 1 281 PHE 281 239 239 PHE PHE A . n 
A 1 282 THR 282 240 240 THR THR A . n 
A 1 283 VAL 283 241 241 VAL VAL A . n 
A 1 284 MET 284 242 242 MET MET A . n 
A 1 285 THR 285 243 243 THR THR A . n 
A 1 286 ASP 286 244 244 ASP ASP A . n 
A 1 287 GLY 287 245 245 GLY GLY A . n 
A 1 288 PRO 288 246 246 PRO PRO A . n 
A 1 289 SER 289 247 247 SER SER A . n 
A 1 290 ASN 290 248 248 ASN ASN A . n 
A 1 291 GLY 291 249 249 GLY GLY A . n 
A 1 292 GLN 292 250 250 GLN GLN A . n 
A 1 293 ALA 293 251 251 ALA ALA A . n 
A 1 294 SER 294 252 252 SER SER A . n 
A 1 295 TYR 295 253 253 TYR TYR A . n 
A 1 296 LYS 296 254 254 LYS LYS A . n 
A 1 297 ILE 297 255 255 ILE ILE A . n 
A 1 298 PHE 298 256 256 PHE PHE A . n 
A 1 299 LYS 299 257 257 LYS LYS A . n 
A 1 300 ILE 300 258 258 ILE ILE A . n 
A 1 301 GLU 301 259 259 GLU GLU A . n 
A 1 302 LYS 302 260 260 LYS LYS A . n 
A 1 303 GLY 303 261 261 GLY GLY A . n 
A 1 304 LYS 304 262 262 LYS LYS A . n 
A 1 305 VAL 305 263 263 VAL VAL A . n 
A 1 306 VAL 306 264 264 VAL VAL A . n 
A 1 307 LYS 307 265 265 LYS LYS A . n 
A 1 308 SER 308 266 266 SER SER A . n 
A 1 309 VAL 309 267 267 VAL VAL A . n 
A 1 310 GLU 310 268 268 GLU GLU A . n 
A 1 311 MET 311 269 269 MET MET A . n 
A 1 312 ASN 312 270 270 ASN ASN A . n 
A 1 313 ALA 313 271 271 ALA ALA A . n 
A 1 314 PRO 314 272 272 PRO PRO A . n 
A 1 315 ASN 315 273 273 ASN ASN A . n 
A 1 316 TYR 316 274 274 TYR TYR A . n 
A 1 317 HIS 317 275 275 HIS HIS A . n 
A 1 318 TYR 318 276 276 TYR TYR A . n 
A 1 319 GLU 319 277 277 GLU GLU A . n 
A 1 320 GLU 320 278 278 GLU GLU A . n 
A 1 321 CYS 321 279 279 CYS CYS A . n 
A 1 322 SER 322 280 280 SER SER A . n 
A 1 323 CYS 323 281 281 CYS CYS A . n 
A 1 324 TYR 324 282 282 TYR TYR A . n 
A 1 325 PRO 325 283 283 PRO PRO A . n 
A 1 326 ASP 326 284 284 ASP ASP A . n 
A 1 327 ALA 327 285 285 ALA ALA A . n 
A 1 328 GLY 328 286 286 GLY GLY A . n 
A 1 329 ASP 329 287 287 ASP ASP A . n 
A 1 330 ILE 330 288 288 ILE ILE A . n 
A 1 331 MET 331 289 289 MET MET A . n 
A 1 332 CYS 332 290 290 CYS CYS A . n 
A 1 333 VAL 333 291 291 VAL VAL A . n 
A 1 334 CYS 334 292 292 CYS CYS A . n 
A 1 335 ARG 335 293 293 ARG ARG A . n 
A 1 336 ASP 336 294 294 ASP ASP A . n 
A 1 337 ASN 337 295 295 ASN ASN A . n 
A 1 338 TRP 338 296 296 TRP TRP A . n 
A 1 339 HIS 339 297 297 HIS HIS A . n 
A 1 340 GLY 340 298 298 GLY GLY A . n 
A 1 341 SER 341 299 299 SER SER A . n 
A 1 342 ASN 342 300 300 ASN ASN A . n 
A 1 343 ARG 343 301 301 ARG ARG A . n 
A 1 344 PRO 344 302 302 PRO PRO A . n 
A 1 345 TRP 345 303 303 TRP TRP A . n 
A 1 346 VAL 346 304 304 VAL VAL A . n 
A 1 347 SER 347 305 305 SER SER A . n 
A 1 348 PHE 348 306 306 PHE PHE A . n 
A 1 349 ASN 349 307 307 ASN ASN A . n 
A 1 350 GLN 350 308 308 GLN GLN A . n 
A 1 351 ASN 351 309 309 ASN ASN A . n 
A 1 352 LEU 352 310 310 LEU LEU A . n 
A 1 353 GLU 353 311 311 GLU GLU A . n 
A 1 354 TYR 354 312 312 TYR TYR A . n 
A 1 355 GLN 355 313 313 GLN GLN A . n 
A 1 356 ILE 356 314 314 ILE ILE A . n 
A 1 357 GLY 357 315 315 GLY GLY A . n 
A 1 358 TYR 358 316 316 TYR TYR A . n 
A 1 359 ILE 359 317 317 ILE ILE A . n 
A 1 360 CYS 360 318 318 CYS CYS A . n 
A 1 361 SER 361 319 319 SER SER A . n 
A 1 362 GLY 362 320 320 GLY GLY A . n 
A 1 363 ILE 363 321 321 ILE ILE A . n 
A 1 364 PHE 364 322 322 PHE PHE A . n 
A 1 365 GLY 365 323 323 GLY GLY A . n 
A 1 366 ASP 366 324 324 ASP ASP A . n 
A 1 367 ASN 367 325 325 ASN ASN A . n 
A 1 368 PRO 368 326 326 PRO PRO A . n 
A 1 369 ARG 369 327 327 ARG ARG A . n 
A 1 370 PRO 370 328 328 PRO PRO A . n 
A 1 371 ASN 371 329 329 ASN ASN A . n 
A 1 372 ASP 372 330 330 ASP ASP A . n 
A 1 373 LYS 373 331 331 LYS LYS A . n 
A 1 374 THR 374 332 332 THR THR A . n 
A 1 375 GLY 375 333 333 GLY GLY A . n 
A 1 376 SER 376 334 334 SER SER A . n 
A 1 377 CYS 377 335 335 CYS CYS A . n 
A 1 378 GLY 378 336 336 GLY GLY A . n 
A 1 379 PRO 379 337 337 PRO PRO A . n 
A 1 380 VAL 380 338 338 VAL VAL A . n 
A 1 381 SER 381 339 339 SER SER A . n 
A 1 382 SER 382 340 340 SER SER A . n 
A 1 383 ASN 383 341 341 ASN ASN A . n 
A 1 384 GLY 384 342 342 GLY GLY A . n 
A 1 385 ALA 385 343 343 ALA ALA A . n 
A 1 386 ASN 386 344 344 ASN ASN A . n 
A 1 387 GLY 387 345 345 GLY GLY A . n 
A 1 388 VAL 388 346 346 VAL VAL A . n 
A 1 389 LYS 389 347 347 LYS LYS A . n 
A 1 390 GLY 390 348 348 GLY GLY A . n 
A 1 391 PHE 391 349 349 PHE PHE A . n 
A 1 392 SER 392 350 350 SER SER A . n 
A 1 393 PHE 393 351 351 PHE PHE A . n 
A 1 394 LYS 394 352 352 LYS LYS A . n 
A 1 395 TYR 395 353 353 TYR TYR A . n 
A 1 396 GLY 396 354 354 GLY GLY A . n 
A 1 397 ASN 397 355 355 ASN ASN A . n 
A 1 398 GLY 398 356 356 GLY GLY A . n 
A 1 399 VAL 399 357 357 VAL VAL A . n 
A 1 400 TRP 400 358 358 TRP TRP A . n 
A 1 401 ILE 401 359 359 ILE ILE A . n 
A 1 402 GLY 402 360 360 GLY GLY A . n 
A 1 403 ARG 403 361 361 ARG ARG A . n 
A 1 404 THR 404 362 362 THR THR A . n 
A 1 405 LYS 405 363 363 LYS LYS A . n 
A 1 406 SER 406 364 364 SER SER A . n 
A 1 407 ILE 407 365 365 ILE ILE A . n 
A 1 408 SER 408 366 366 SER SER A . n 
A 1 409 SER 409 367 367 SER SER A . n 
A 1 410 ARG 410 368 368 ARG ARG A . n 
A 1 411 ASN 411 369 369 ASN ASN A . n 
A 1 412 GLY 412 370 370 GLY GLY A . n 
A 1 413 PHE 413 371 371 PHE PHE A . n 
A 1 414 GLU 414 372 372 GLU GLU A . n 
A 1 415 MET 415 373 373 MET MET A . n 
A 1 416 ILE 416 374 374 ILE ILE A . n 
A 1 417 TRP 417 375 375 TRP TRP A . n 
A 1 418 ASP 418 376 376 ASP ASP A . n 
A 1 419 PRO 419 377 377 PRO PRO A . n 
A 1 420 ASN 420 378 378 ASN ASN A . n 
A 1 421 GLY 421 379 379 GLY GLY A . n 
A 1 422 TRP 422 380 380 TRP TRP A . n 
A 1 423 THR 423 381 381 THR THR A . n 
A 1 424 GLU 424 382 382 GLU GLU A . n 
A 1 425 THR 425 383 383 THR THR A . n 
A 1 426 ASP 426 384 384 ASP ASP A . n 
A 1 427 SER 427 385 385 SER SER A . n 
A 1 428 SER 428 386 386 SER SER A . n 
A 1 429 PHE 429 387 387 PHE PHE A . n 
A 1 430 SER 430 388 388 SER SER A . n 
A 1 431 VAL 431 389 389 VAL VAL A . n 
A 1 432 LYS 432 390 390 LYS LYS A . n 
A 1 433 GLN 433 391 391 GLN GLN A . n 
A 1 434 ASP 434 392 392 ASP ASP A . n 
A 1 435 ILE 435 393 393 ILE ILE A . n 
A 1 436 VAL 436 394 394 VAL VAL A . n 
A 1 437 GLY 437 395 395 GLY GLY A . n 
A 1 438 ILE 438 396 396 ILE ILE A . n 
A 1 439 ASN 439 397 397 ASN ASN A . n 
A 1 440 GLU 440 398 398 GLU GLU A . n 
A 1 441 TRP 441 399 399 TRP TRP A . n 
A 1 442 SER 442 400 400 SER SER A . n 
A 1 443 GLY 443 401 401 GLY GLY A . n 
A 1 444 TYR 444 402 402 TYR TYR A . n 
A 1 445 SER 445 403 403 SER SER A . n 
A 1 446 GLY 446 404 404 GLY GLY A . n 
A 1 447 SER 447 405 405 SER SER A . n 
A 1 448 PHE 448 406 406 PHE PHE A . n 
A 1 449 VAL 449 407 407 VAL VAL A . n 
A 1 450 GLN 450 408 408 GLN GLN A . n 
A 1 451 HIS 451 409 409 HIS HIS A . n 
A 1 452 PRO 452 410 410 PRO PRO A . n 
A 1 453 GLU 453 411 411 GLU GLU A . n 
A 1 454 MET 454 412 412 MET MET A . n 
A 1 455 THR 455 413 413 THR THR A . n 
A 1 456 GLY 456 414 414 GLY GLY A . n 
A 1 457 LEU 457 415 415 LEU LEU A . n 
A 1 458 ASP 458 416 416 ASP ASP A . n 
A 1 459 CYS 459 417 417 CYS CYS A . n 
A 1 460 MET 460 418 418 MET MET A . n 
A 1 461 ARG 461 419 419 ARG ARG A . n 
A 1 462 PRO 462 420 420 PRO PRO A . n 
A 1 463 CYS 463 421 421 CYS CYS A . n 
A 1 464 PHE 464 422 422 PHE PHE A . n 
A 1 465 TRP 465 423 423 TRP TRP A . n 
A 1 466 VAL 466 424 424 VAL VAL A . n 
A 1 467 GLU 467 425 425 GLU GLU A . n 
A 1 468 LEU 468 426 426 LEU LEU A . n 
A 1 469 ILE 469 427 427 ILE ILE A . n 
A 1 470 ARG 470 428 428 ARG ARG A . n 
A 1 471 GLY 471 429 429 GLY GLY A . n 
A 1 472 ARG 472 430 430 ARG ARG A . n 
A 1 473 PRO 473 431 431 PRO PRO A . n 
A 1 474 LYS 474 432 432 LYS LYS A . n 
A 1 475 GLU 475 433 433 GLU GLU A . n 
A 1 476 ASN 476 434 434 ASN ASN A . n 
A 1 477 THR 477 435 435 THR THR A . n 
A 1 478 ILE 478 436 436 ILE ILE A . n 
A 1 479 TRP 479 437 437 TRP TRP A . n 
A 1 480 THR 480 438 438 THR THR A . n 
A 1 481 SER 481 439 439 SER SER A . n 
A 1 482 GLY 482 440 440 GLY GLY A . n 
A 1 483 SER 483 441 441 SER SER A . n 
A 1 484 SER 484 442 442 SER SER A . n 
A 1 485 ILE 485 443 443 ILE ILE A . n 
A 1 486 SER 486 444 444 SER SER A . n 
A 1 487 PHE 487 445 445 PHE PHE A . n 
A 1 488 CYS 488 446 446 CYS CYS A . n 
A 1 489 GLY 489 447 447 GLY GLY A . n 
A 1 490 VAL 490 448 448 VAL VAL A . n 
A 1 491 ASN 491 449 449 ASN ASN A . n 
A 1 492 SER 492 450 450 SER SER A . n 
A 1 493 ASP 493 451 451 ASP ASP A . n 
A 1 494 THR 494 452 452 THR THR A . n 
A 1 495 VAL 495 453 453 VAL VAL A . n 
A 1 496 GLY 496 454 454 GLY GLY A . n 
A 1 497 TRP 497 455 455 TRP TRP A . n 
A 1 498 SER 498 456 456 SER SER A . n 
A 1 499 TRP 499 457 457 TRP TRP A . n 
A 1 500 PRO 500 458 458 PRO PRO A . n 
A 1 501 ASP 501 459 459 ASP ASP A . n 
A 1 502 GLY 502 460 460 GLY GLY A . n 
A 1 503 ALA 503 461 461 ALA ALA A . n 
A 1 504 GLU 504 462 462 GLU GLU A . n 
A 1 505 LEU 505 463 463 LEU LEU A . n 
A 1 506 PRO 506 464 464 PRO PRO A . n 
A 1 507 PHE 507 465 465 PHE PHE A . n 
A 1 508 THR 508 466 466 THR THR A . n 
A 1 509 ILE 509 467 467 ILE ILE A . n 
A 1 510 ASP 510 468 468 ASP ASP A . n 
A 1 511 LYS 511 469 469 LYS LYS A . n 
B 1 1   MET 1   -41 ?   ?   ?   B . n 
B 1 2   ASN 2   -40 ?   ?   ?   B . n 
B 1 3   THR 3   -39 ?   ?   ?   B . n 
B 1 4   GLN 4   -38 ?   ?   ?   B . n 
B 1 5   ILE 5   -37 ?   ?   ?   B . n 
B 1 6   LEU 6   -36 ?   ?   ?   B . n 
B 1 7   VAL 7   -35 ?   ?   ?   B . n 
B 1 8   PHE 8   -34 ?   ?   ?   B . n 
B 1 9   ALA 9   -33 ?   ?   ?   B . n 
B 1 10  LEU 10  -32 ?   ?   ?   B . n 
B 1 11  ILE 11  -31 ?   ?   ?   B . n 
B 1 12  ALA 12  -30 ?   ?   ?   B . n 
B 1 13  ILE 13  -29 ?   ?   ?   B . n 
B 1 14  ILE 14  -28 ?   ?   ?   B . n 
B 1 15  PRO 15  -27 ?   ?   ?   B . n 
B 1 16  THR 16  -26 ?   ?   ?   B . n 
B 1 17  ASN 17  -25 ?   ?   ?   B . n 
B 1 18  ALA 18  -24 ?   ?   ?   B . n 
B 1 19  ASP 19  -23 ?   ?   ?   B . n 
B 1 20  LYS 20  -22 ?   ?   ?   B . n 
B 1 21  ILE 21  -21 ?   ?   ?   B . n 
B 1 22  SER 22  -20 ?   ?   ?   B . n 
B 1 23  ALA 23  -19 ?   ?   ?   B . n 
B 1 24  TRP 24  -18 ?   ?   ?   B . n 
B 1 25  SER 25  -17 ?   ?   ?   B . n 
B 1 26  HIS 26  -16 ?   ?   ?   B . n 
B 1 27  PRO 27  -15 ?   ?   ?   B . n 
B 1 28  GLN 28  -14 ?   ?   ?   B . n 
B 1 29  PHE 29  -13 ?   ?   ?   B . n 
B 1 30  GLU 30  -12 ?   ?   ?   B . n 
B 1 31  LYS 31  -11 ?   ?   ?   B . n 
B 1 32  GLY 32  -10 ?   ?   ?   B . n 
B 1 33  GLY 33  -9  ?   ?   ?   B . n 
B 1 34  GLY 34  -8  ?   ?   ?   B . n 
B 1 35  GLY 35  -7  ?   ?   ?   B . n 
B 1 36  SER 36  -6  ?   ?   ?   B . n 
B 1 37  HIS 37  -5  ?   ?   ?   B . n 
B 1 38  HIS 38  -4  ?   ?   ?   B . n 
B 1 39  HIS 39  -3  ?   ?   ?   B . n 
B 1 40  HIS 40  -2  ?   ?   ?   B . n 
B 1 41  HIS 41  -1  ?   ?   ?   B . n 
B 1 42  HIS 42  0   ?   ?   ?   B . n 
B 1 43  SER 43  1   ?   ?   ?   B . n 
B 1 44  SER 44  2   ?   ?   ?   B . n 
B 1 45  SER 45  3   ?   ?   ?   B . n 
B 1 46  GLY 46  4   ?   ?   ?   B . n 
B 1 47  SER 47  5   ?   ?   ?   B . n 
B 1 48  GLY 48  6   ?   ?   ?   B . n 
B 1 49  ALA 49  7   ?   ?   ?   B . n 
B 1 50  HIS 50  8   ?   ?   ?   B . n 
B 1 51  ILE 51  9   ?   ?   ?   B . n 
B 1 52  VAL 52  10  ?   ?   ?   B . n 
B 1 53  MET 53  11  ?   ?   ?   B . n 
B 1 54  VAL 54  12  ?   ?   ?   B . n 
B 1 55  ASP 55  13  ?   ?   ?   B . n 
B 1 56  ALA 56  14  ?   ?   ?   B . n 
B 1 57  TYR 57  15  ?   ?   ?   B . n 
B 1 58  LYS 58  16  ?   ?   ?   B . n 
B 1 59  PRO 59  17  ?   ?   ?   B . n 
B 1 60  THR 60  18  ?   ?   ?   B . n 
B 1 61  LYS 61  19  ?   ?   ?   B . n 
B 1 62  GLY 62  20  ?   ?   ?   B . n 
B 1 63  GLY 63  21  ?   ?   ?   B . n 
B 1 64  SER 64  22  ?   ?   ?   B . n 
B 1 65  GLY 65  23  ?   ?   ?   B . n 
B 1 66  GLY 66  24  ?   ?   ?   B . n 
B 1 67  GLY 67  25  ?   ?   ?   B . n 
B 1 68  GLY 68  26  ?   ?   ?   B . n 
B 1 69  SER 69  27  ?   ?   ?   B . n 
B 1 70  ILE 70  28  ?   ?   ?   B . n 
B 1 71  ILE 71  29  ?   ?   ?   B . n 
B 1 72  ASN 72  30  ?   ?   ?   B . n 
B 1 73  GLU 73  31  ?   ?   ?   B . n 
B 1 74  THR 74  32  ?   ?   ?   B . n 
B 1 75  ALA 75  33  ?   ?   ?   B . n 
B 1 76  ASP 76  34  ?   ?   ?   B . n 
B 1 77  ASP 77  35  ?   ?   ?   B . n 
B 1 78  ILE 78  36  ?   ?   ?   B . n 
B 1 79  VAL 79  37  ?   ?   ?   B . n 
B 1 80  TYR 80  38  ?   ?   ?   B . n 
B 1 81  ARG 81  39  ?   ?   ?   B . n 
B 1 82  LEU 82  40  ?   ?   ?   B . n 
B 1 83  THR 83  41  ?   ?   ?   B . n 
B 1 84  VAL 84  42  ?   ?   ?   B . n 
B 1 85  ILE 85  43  ?   ?   ?   B . n 
B 1 86  ILE 86  44  ?   ?   ?   B . n 
B 1 87  ASP 87  45  ?   ?   ?   B . n 
B 1 88  ASP 88  46  ?   ?   ?   B . n 
B 1 89  ARG 89  47  ?   ?   ?   B . n 
B 1 90  TYR 90  48  ?   ?   ?   B . n 
B 1 91  GLU 91  49  ?   ?   ?   B . n 
B 1 92  SER 92  50  ?   ?   ?   B . n 
B 1 93  LEU 93  51  ?   ?   ?   B . n 
B 1 94  LYS 94  52  ?   ?   ?   B . n 
B 1 95  ASN 95  53  ?   ?   ?   B . n 
B 1 96  LEU 96  54  ?   ?   ?   B . n 
B 1 97  ILE 97  55  ?   ?   ?   B . n 
B 1 98  THR 98  56  ?   ?   ?   B . n 
B 1 99  LEU 99  57  ?   ?   ?   B . n 
B 1 100 ARG 100 58  ?   ?   ?   B . n 
B 1 101 ALA 101 59  ?   ?   ?   B . n 
B 1 102 ASP 102 60  ?   ?   ?   B . n 
B 1 103 ARG 103 61  ?   ?   ?   B . n 
B 1 104 LEU 104 62  ?   ?   ?   B . n 
B 1 105 GLU 105 63  ?   ?   ?   B . n 
B 1 106 MET 106 64  ?   ?   ?   B . n 
B 1 107 ILE 107 65  ?   ?   ?   B . n 
B 1 108 ILE 108 66  66  ILE ILE B . n 
B 1 109 ASN 109 67  67  ASN ASN B . n 
B 1 110 ASP 110 68  68  ASP ASP B . n 
B 1 111 ASN 111 69  69  ASN ASN B . n 
B 1 112 VAL 112 70  70  VAL VAL B . n 
B 1 113 SER 113 71  71  SER SER B . n 
B 1 114 THR 114 72  72  THR THR B . n 
B 1 115 ILE 115 73  73  ILE ILE B . n 
B 1 116 LEU 116 74  74  LEU LEU B . n 
B 1 117 ALA 117 75  75  ALA ALA B . n 
B 1 118 GLY 118 76  76  GLY GLY B . n 
B 1 119 GLY 119 77  77  GLY GLY B . n 
B 1 120 SER 120 78  78  SER SER B . n 
B 1 121 GLY 121 79  79  GLY GLY B . n 
B 1 122 THR 122 80  80  THR THR B . n 
B 1 123 GLY 123 81  81  GLY GLY B . n 
B 1 124 SER 124 82  82  SER SER B . n 
B 1 125 VAL 125 83  83  VAL VAL B . n 
B 1 126 THR 126 84  84  THR THR B . n 
B 1 127 LEU 127 85  85  LEU LEU B . n 
B 1 128 ALA 128 86  86  ALA ALA B . n 
B 1 129 GLY 129 87  87  GLY GLY B . n 
B 1 130 ASN 130 88  88  ASN ASN B . n 
B 1 131 SER 131 89  89  SER SER B . n 
B 1 132 SER 132 90  90  SER SER B . n 
B 1 133 LEU 133 91  91  LEU LEU B . n 
B 1 134 CYS 134 92  92  CYS CYS B . n 
B 1 135 PRO 135 93  93  PRO PRO B . n 
B 1 136 ILE 136 94  94  ILE ILE B . n 
B 1 137 SER 137 95  95  SER SER B . n 
B 1 138 GLY 138 96  96  GLY GLY B . n 
B 1 139 TRP 139 97  97  TRP TRP B . n 
B 1 140 ALA 140 98  98  ALA ALA B . n 
B 1 141 ILE 141 99  99  ILE ILE B . n 
B 1 142 TYR 142 100 100 TYR TYR B . n 
B 1 143 SER 143 101 101 SER SER B . n 
B 1 144 LYS 144 102 102 LYS LYS B . n 
B 1 145 ASP 145 103 103 ASP ASP B . n 
B 1 146 ASN 146 104 104 ASN ASN B . n 
B 1 147 GLY 147 105 105 GLY GLY B . n 
B 1 148 ILE 148 106 106 ILE ILE B . n 
B 1 149 ARG 149 107 107 ARG ARG B . n 
B 1 150 ILE 150 108 108 ILE ILE B . n 
B 1 151 GLY 151 109 109 GLY GLY B . n 
B 1 152 SER 152 110 110 SER SER B . n 
B 1 153 LYS 153 111 111 LYS LYS B . n 
B 1 154 GLY 154 112 112 GLY GLY B . n 
B 1 155 ASP 155 113 113 ASP ASP B . n 
B 1 156 VAL 156 114 114 VAL VAL B . n 
B 1 157 PHE 157 115 115 PHE PHE B . n 
B 1 158 VAL 158 116 116 VAL VAL B . n 
B 1 159 ILE 159 117 117 ILE ILE B . n 
B 1 160 ARG 160 118 118 ARG ARG B . n 
B 1 161 GLU 161 119 119 GLU GLU B . n 
B 1 162 PRO 162 120 120 PRO PRO B . n 
B 1 163 PHE 163 121 121 PHE PHE B . n 
B 1 164 ILE 164 122 122 ILE ILE B . n 
B 1 165 SER 165 123 123 SER SER B . n 
B 1 166 CYS 166 124 124 CYS CYS B . n 
B 1 167 SER 167 125 125 SER SER B . n 
B 1 168 HIS 168 126 126 HIS HIS B . n 
B 1 169 LEU 169 127 127 LEU LEU B . n 
B 1 170 GLU 170 128 128 GLU GLU B . n 
B 1 171 CYS 171 129 129 CYS CYS B . n 
B 1 172 ARG 172 130 130 ARG ARG B . n 
B 1 173 THR 173 131 131 THR THR B . n 
B 1 174 PHE 174 132 132 PHE PHE B . n 
B 1 175 PHE 175 133 133 PHE PHE B . n 
B 1 176 LEU 176 134 134 LEU LEU B . n 
B 1 177 THR 177 135 135 THR THR B . n 
B 1 178 GLN 178 136 136 GLN GLN B . n 
B 1 179 GLY 179 137 137 GLY GLY B . n 
B 1 180 ALA 180 138 138 ALA ALA B . n 
B 1 181 LEU 181 139 139 LEU LEU B . n 
B 1 182 LEU 182 140 140 LEU LEU B . n 
B 1 183 ASN 183 141 141 ASN ASN B . n 
B 1 184 ASP 184 142 142 ASP ASP B . n 
B 1 185 LYS 185 143 143 LYS LYS B . n 
B 1 186 HIS 186 144 144 HIS HIS B . n 
B 1 187 SER 187 145 145 SER SER B . n 
B 1 188 ASN 188 146 146 ASN ASN B . n 
B 1 189 GLY 189 147 147 GLY GLY B . n 
B 1 190 THR 190 148 148 THR THR B . n 
B 1 191 ILE 191 149 149 ILE ILE B . n 
B 1 192 LYS 192 150 150 LYS LYS B . n 
B 1 193 ASP 193 151 151 ASP ASP B . n 
B 1 194 ARG 194 152 152 ARG ARG B . n 
B 1 195 SER 195 153 153 SER SER B . n 
B 1 196 PRO 196 154 154 PRO PRO B . n 
B 1 197 TYR 197 155 155 TYR TYR B . n 
B 1 198 ARG 198 156 156 ARG ARG B . n 
B 1 199 THR 199 157 157 THR THR B . n 
B 1 200 LEU 200 158 158 LEU LEU B . n 
B 1 201 MET 201 159 159 MET MET B . n 
B 1 202 SER 202 160 160 SER SER B . n 
B 1 203 CYS 203 161 161 CYS CYS B . n 
B 1 204 PRO 204 162 162 PRO PRO B . n 
B 1 205 VAL 205 163 163 VAL VAL B . n 
B 1 206 GLY 206 164 164 GLY GLY B . n 
B 1 207 GLU 207 165 165 GLU GLU B . n 
B 1 208 ALA 208 166 166 ALA ALA B . n 
B 1 209 PRO 209 167 167 PRO PRO B . n 
B 1 210 SER 210 168 168 SER SER B . n 
B 1 211 PRO 211 169 169 PRO PRO B . n 
B 1 212 TYR 212 170 170 TYR TYR B . n 
B 1 213 ASN 213 171 171 ASN ASN B . n 
B 1 214 SER 214 172 172 SER SER B . n 
B 1 215 ARG 215 173 173 ARG ARG B . n 
B 1 216 PHE 216 174 174 PHE PHE B . n 
B 1 217 GLU 217 175 175 GLU GLU B . n 
B 1 218 SER 218 176 176 SER SER B . n 
B 1 219 VAL 219 177 177 VAL VAL B . n 
B 1 220 ALA 220 178 178 ALA ALA B . n 
B 1 221 TRP 221 179 179 TRP TRP B . n 
B 1 222 SER 222 180 180 SER SER B . n 
B 1 223 ALA 223 181 181 ALA ALA B . n 
B 1 224 SER 224 182 182 SER SER B . n 
B 1 225 ALA 225 183 183 ALA ALA B . n 
B 1 226 CYS 226 184 184 CYS CYS B . n 
B 1 227 HIS 227 185 185 HIS HIS B . n 
B 1 228 ASP 228 186 186 ASP ASP B . n 
B 1 229 GLY 229 187 187 GLY GLY B . n 
B 1 230 ILE 230 188 188 ILE ILE B . n 
B 1 231 SER 231 189 189 SER SER B . n 
B 1 232 TRP 232 190 190 TRP TRP B . n 
B 1 233 LEU 233 191 191 LEU LEU B . n 
B 1 234 THR 234 192 192 THR THR B . n 
B 1 235 ILE 235 193 193 ILE ILE B . n 
B 1 236 GLY 236 194 194 GLY GLY B . n 
B 1 237 ILE 237 195 195 ILE ILE B . n 
B 1 238 SER 238 196 196 SER SER B . n 
B 1 239 GLY 239 197 197 GLY GLY B . n 
B 1 240 PRO 240 198 198 PRO PRO B . n 
B 1 241 ASP 241 199 199 ASP ASP B . n 
B 1 242 ASN 242 200 200 ASN ASN B . n 
B 1 243 GLY 243 201 201 GLY GLY B . n 
B 1 244 ALA 244 202 202 ALA ALA B . n 
B 1 245 VAL 245 203 203 VAL VAL B . n 
B 1 246 ALA 246 204 204 ALA ALA B . n 
B 1 247 VAL 247 205 205 VAL VAL B . n 
B 1 248 VAL 248 206 206 VAL VAL B . n 
B 1 249 LYS 249 207 207 LYS LYS B . n 
B 1 250 TYR 250 208 208 TYR TYR B . n 
B 1 251 ASN 251 209 209 ASN ASN B . n 
B 1 252 GLY 252 210 210 GLY GLY B . n 
B 1 253 ILE 253 211 211 ILE ILE B . n 
B 1 254 ILE 254 212 212 ILE ILE B . n 
B 1 255 THR 255 213 213 THR THR B . n 
B 1 256 ASP 256 214 214 ASP ASP B . n 
B 1 257 THR 257 215 215 THR THR B . n 
B 1 258 ILE 258 216 216 ILE ILE B . n 
B 1 259 LYS 259 217 217 LYS LYS B . n 
B 1 260 SER 260 218 218 SER SER B . n 
B 1 261 TRP 261 219 219 TRP TRP B . n 
B 1 262 ARG 262 220 220 ARG ARG B . n 
B 1 263 ASN 263 221 221 ASN ASN B . n 
B 1 264 ASN 264 222 222 ASN ASN B . n 
B 1 265 ILE 265 223 223 ILE ILE B . n 
B 1 266 LEU 266 224 224 LEU LEU B . n 
B 1 267 ARG 267 225 225 ARG ARG B . n 
B 1 268 THR 268 226 226 THR THR B . n 
B 1 269 GLN 269 227 227 GLN GLN B . n 
B 1 270 GLU 270 228 228 GLU GLU B . n 
B 1 271 SER 271 229 229 SER SER B . n 
B 1 272 GLU 272 230 230 GLU GLU B . n 
B 1 273 CYS 273 231 231 CYS CYS B . n 
B 1 274 ALA 274 232 232 ALA ALA B . n 
B 1 275 CYS 275 233 233 CYS CYS B . n 
B 1 276 VAL 276 234 234 VAL VAL B . n 
B 1 277 ASN 277 235 235 ASN ASN B . n 
B 1 278 GLY 278 236 236 GLY GLY B . n 
B 1 279 SER 279 237 237 SER SER B . n 
B 1 280 CYS 280 238 238 CYS CYS B . n 
B 1 281 PHE 281 239 239 PHE PHE B . n 
B 1 282 THR 282 240 240 THR THR B . n 
B 1 283 VAL 283 241 241 VAL VAL B . n 
B 1 284 MET 284 242 242 MET MET B . n 
B 1 285 THR 285 243 243 THR THR B . n 
B 1 286 ASP 286 244 244 ASP ASP B . n 
B 1 287 GLY 287 245 245 GLY GLY B . n 
B 1 288 PRO 288 246 246 PRO PRO B . n 
B 1 289 SER 289 247 247 SER SER B . n 
B 1 290 ASN 290 248 248 ASN ASN B . n 
B 1 291 GLY 291 249 249 GLY GLY B . n 
B 1 292 GLN 292 250 250 GLN GLN B . n 
B 1 293 ALA 293 251 251 ALA ALA B . n 
B 1 294 SER 294 252 252 SER SER B . n 
B 1 295 TYR 295 253 253 TYR TYR B . n 
B 1 296 LYS 296 254 254 LYS LYS B . n 
B 1 297 ILE 297 255 255 ILE ILE B . n 
B 1 298 PHE 298 256 256 PHE PHE B . n 
B 1 299 LYS 299 257 257 LYS LYS B . n 
B 1 300 ILE 300 258 258 ILE ILE B . n 
B 1 301 GLU 301 259 259 GLU GLU B . n 
B 1 302 LYS 302 260 260 LYS LYS B . n 
B 1 303 GLY 303 261 261 GLY GLY B . n 
B 1 304 LYS 304 262 262 LYS LYS B . n 
B 1 305 VAL 305 263 263 VAL VAL B . n 
B 1 306 VAL 306 264 264 VAL VAL B . n 
B 1 307 LYS 307 265 265 LYS LYS B . n 
B 1 308 SER 308 266 266 SER SER B . n 
B 1 309 VAL 309 267 267 VAL VAL B . n 
B 1 310 GLU 310 268 268 GLU GLU B . n 
B 1 311 MET 311 269 269 MET MET B . n 
B 1 312 ASN 312 270 270 ASN ASN B . n 
B 1 313 ALA 313 271 271 ALA ALA B . n 
B 1 314 PRO 314 272 272 PRO PRO B . n 
B 1 315 ASN 315 273 273 ASN ASN B . n 
B 1 316 TYR 316 274 274 TYR TYR B . n 
B 1 317 HIS 317 275 275 HIS HIS B . n 
B 1 318 TYR 318 276 276 TYR TYR B . n 
B 1 319 GLU 319 277 277 GLU GLU B . n 
B 1 320 GLU 320 278 278 GLU GLU B . n 
B 1 321 CYS 321 279 279 CYS CYS B . n 
B 1 322 SER 322 280 280 SER SER B . n 
B 1 323 CYS 323 281 281 CYS CYS B . n 
B 1 324 TYR 324 282 282 TYR TYR B . n 
B 1 325 PRO 325 283 283 PRO PRO B . n 
B 1 326 ASP 326 284 284 ASP ASP B . n 
B 1 327 ALA 327 285 285 ALA ALA B . n 
B 1 328 GLY 328 286 286 GLY GLY B . n 
B 1 329 ASP 329 287 287 ASP ASP B . n 
B 1 330 ILE 330 288 288 ILE ILE B . n 
B 1 331 MET 331 289 289 MET MET B . n 
B 1 332 CYS 332 290 290 CYS CYS B . n 
B 1 333 VAL 333 291 291 VAL VAL B . n 
B 1 334 CYS 334 292 292 CYS CYS B . n 
B 1 335 ARG 335 293 293 ARG ARG B . n 
B 1 336 ASP 336 294 294 ASP ASP B . n 
B 1 337 ASN 337 295 295 ASN ASN B . n 
B 1 338 TRP 338 296 296 TRP TRP B . n 
B 1 339 HIS 339 297 297 HIS HIS B . n 
B 1 340 GLY 340 298 298 GLY GLY B . n 
B 1 341 SER 341 299 299 SER SER B . n 
B 1 342 ASN 342 300 300 ASN ASN B . n 
B 1 343 ARG 343 301 301 ARG ARG B . n 
B 1 344 PRO 344 302 302 PRO PRO B . n 
B 1 345 TRP 345 303 303 TRP TRP B . n 
B 1 346 VAL 346 304 304 VAL VAL B . n 
B 1 347 SER 347 305 305 SER SER B . n 
B 1 348 PHE 348 306 306 PHE PHE B . n 
B 1 349 ASN 349 307 307 ASN ASN B . n 
B 1 350 GLN 350 308 308 GLN GLN B . n 
B 1 351 ASN 351 309 309 ASN ASN B . n 
B 1 352 LEU 352 310 310 LEU LEU B . n 
B 1 353 GLU 353 311 311 GLU GLU B . n 
B 1 354 TYR 354 312 312 TYR TYR B . n 
B 1 355 GLN 355 313 313 GLN GLN B . n 
B 1 356 ILE 356 314 314 ILE ILE B . n 
B 1 357 GLY 357 315 315 GLY GLY B . n 
B 1 358 TYR 358 316 316 TYR TYR B . n 
B 1 359 ILE 359 317 317 ILE ILE B . n 
B 1 360 CYS 360 318 318 CYS CYS B . n 
B 1 361 SER 361 319 319 SER SER B . n 
B 1 362 GLY 362 320 320 GLY GLY B . n 
B 1 363 ILE 363 321 321 ILE ILE B . n 
B 1 364 PHE 364 322 322 PHE PHE B . n 
B 1 365 GLY 365 323 323 GLY GLY B . n 
B 1 366 ASP 366 324 324 ASP ASP B . n 
B 1 367 ASN 367 325 325 ASN ASN B . n 
B 1 368 PRO 368 326 326 PRO PRO B . n 
B 1 369 ARG 369 327 327 ARG ARG B . n 
B 1 370 PRO 370 328 328 PRO PRO B . n 
B 1 371 ASN 371 329 329 ASN ASN B . n 
B 1 372 ASP 372 330 330 ASP ASP B . n 
B 1 373 LYS 373 331 331 LYS LYS B . n 
B 1 374 THR 374 332 332 THR THR B . n 
B 1 375 GLY 375 333 333 GLY GLY B . n 
B 1 376 SER 376 334 334 SER SER B . n 
B 1 377 CYS 377 335 335 CYS CYS B . n 
B 1 378 GLY 378 336 336 GLY GLY B . n 
B 1 379 PRO 379 337 337 PRO PRO B . n 
B 1 380 VAL 380 338 338 VAL VAL B . n 
B 1 381 SER 381 339 339 SER SER B . n 
B 1 382 SER 382 340 340 SER SER B . n 
B 1 383 ASN 383 341 341 ASN ASN B . n 
B 1 384 GLY 384 342 342 GLY GLY B . n 
B 1 385 ALA 385 343 343 ALA ALA B . n 
B 1 386 ASN 386 344 344 ASN ASN B . n 
B 1 387 GLY 387 345 345 GLY GLY B . n 
B 1 388 VAL 388 346 346 VAL VAL B . n 
B 1 389 LYS 389 347 347 LYS LYS B . n 
B 1 390 GLY 390 348 348 GLY GLY B . n 
B 1 391 PHE 391 349 349 PHE PHE B . n 
B 1 392 SER 392 350 350 SER SER B . n 
B 1 393 PHE 393 351 351 PHE PHE B . n 
B 1 394 LYS 394 352 352 LYS LYS B . n 
B 1 395 TYR 395 353 353 TYR TYR B . n 
B 1 396 GLY 396 354 354 GLY GLY B . n 
B 1 397 ASN 397 355 355 ASN ASN B . n 
B 1 398 GLY 398 356 356 GLY GLY B . n 
B 1 399 VAL 399 357 357 VAL VAL B . n 
B 1 400 TRP 400 358 358 TRP TRP B . n 
B 1 401 ILE 401 359 359 ILE ILE B . n 
B 1 402 GLY 402 360 360 GLY GLY B . n 
B 1 403 ARG 403 361 361 ARG ARG B . n 
B 1 404 THR 404 362 362 THR THR B . n 
B 1 405 LYS 405 363 363 LYS LYS B . n 
B 1 406 SER 406 364 364 SER SER B . n 
B 1 407 ILE 407 365 365 ILE ILE B . n 
B 1 408 SER 408 366 366 SER SER B . n 
B 1 409 SER 409 367 367 SER SER B . n 
B 1 410 ARG 410 368 368 ARG ARG B . n 
B 1 411 ASN 411 369 369 ASN ASN B . n 
B 1 412 GLY 412 370 370 GLY GLY B . n 
B 1 413 PHE 413 371 371 PHE PHE B . n 
B 1 414 GLU 414 372 372 GLU GLU B . n 
B 1 415 MET 415 373 373 MET MET B . n 
B 1 416 ILE 416 374 374 ILE ILE B . n 
B 1 417 TRP 417 375 375 TRP TRP B . n 
B 1 418 ASP 418 376 376 ASP ASP B . n 
B 1 419 PRO 419 377 377 PRO PRO B . n 
B 1 420 ASN 420 378 378 ASN ASN B . n 
B 1 421 GLY 421 379 379 GLY GLY B . n 
B 1 422 TRP 422 380 380 TRP TRP B . n 
B 1 423 THR 423 381 381 THR THR B . n 
B 1 424 GLU 424 382 382 GLU GLU B . n 
B 1 425 THR 425 383 383 THR THR B . n 
B 1 426 ASP 426 384 384 ASP ASP B . n 
B 1 427 SER 427 385 385 SER SER B . n 
B 1 428 SER 428 386 386 SER SER B . n 
B 1 429 PHE 429 387 387 PHE PHE B . n 
B 1 430 SER 430 388 388 SER SER B . n 
B 1 431 VAL 431 389 389 VAL VAL B . n 
B 1 432 LYS 432 390 390 LYS LYS B . n 
B 1 433 GLN 433 391 391 GLN GLN B . n 
B 1 434 ASP 434 392 392 ASP ASP B . n 
B 1 435 ILE 435 393 393 ILE ILE B . n 
B 1 436 VAL 436 394 394 VAL VAL B . n 
B 1 437 GLY 437 395 395 GLY GLY B . n 
B 1 438 ILE 438 396 396 ILE ILE B . n 
B 1 439 ASN 439 397 397 ASN ASN B . n 
B 1 440 GLU 440 398 398 GLU GLU B . n 
B 1 441 TRP 441 399 399 TRP TRP B . n 
B 1 442 SER 442 400 400 SER SER B . n 
B 1 443 GLY 443 401 401 GLY GLY B . n 
B 1 444 TYR 444 402 402 TYR TYR B . n 
B 1 445 SER 445 403 403 SER SER B . n 
B 1 446 GLY 446 404 404 GLY GLY B . n 
B 1 447 SER 447 405 405 SER SER B . n 
B 1 448 PHE 448 406 406 PHE PHE B . n 
B 1 449 VAL 449 407 407 VAL VAL B . n 
B 1 450 GLN 450 408 408 GLN GLN B . n 
B 1 451 HIS 451 409 409 HIS HIS B . n 
B 1 452 PRO 452 410 410 PRO PRO B . n 
B 1 453 GLU 453 411 411 GLU GLU B . n 
B 1 454 MET 454 412 412 MET MET B . n 
B 1 455 THR 455 413 413 THR THR B . n 
B 1 456 GLY 456 414 414 GLY GLY B . n 
B 1 457 LEU 457 415 415 LEU LEU B . n 
B 1 458 ASP 458 416 416 ASP ASP B . n 
B 1 459 CYS 459 417 417 CYS CYS B . n 
B 1 460 MET 460 418 418 MET MET B . n 
B 1 461 ARG 461 419 419 ARG ARG B . n 
B 1 462 PRO 462 420 420 PRO PRO B . n 
B 1 463 CYS 463 421 421 CYS CYS B . n 
B 1 464 PHE 464 422 422 PHE PHE B . n 
B 1 465 TRP 465 423 423 TRP TRP B . n 
B 1 466 VAL 466 424 424 VAL VAL B . n 
B 1 467 GLU 467 425 425 GLU GLU B . n 
B 1 468 LEU 468 426 426 LEU LEU B . n 
B 1 469 ILE 469 427 427 ILE ILE B . n 
B 1 470 ARG 470 428 428 ARG ARG B . n 
B 1 471 GLY 471 429 429 GLY GLY B . n 
B 1 472 ARG 472 430 430 ARG ARG B . n 
B 1 473 PRO 473 431 431 PRO PRO B . n 
B 1 474 LYS 474 432 432 LYS LYS B . n 
B 1 475 GLU 475 433 433 GLU GLU B . n 
B 1 476 ASN 476 434 434 ASN ASN B . n 
B 1 477 THR 477 435 435 THR THR B . n 
B 1 478 ILE 478 436 436 ILE ILE B . n 
B 1 479 TRP 479 437 437 TRP TRP B . n 
B 1 480 THR 480 438 438 THR THR B . n 
B 1 481 SER 481 439 439 SER SER B . n 
B 1 482 GLY 482 440 440 GLY GLY B . n 
B 1 483 SER 483 441 441 SER SER B . n 
B 1 484 SER 484 442 442 SER SER B . n 
B 1 485 ILE 485 443 443 ILE ILE B . n 
B 1 486 SER 486 444 444 SER SER B . n 
B 1 487 PHE 487 445 445 PHE PHE B . n 
B 1 488 CYS 488 446 446 CYS CYS B . n 
B 1 489 GLY 489 447 447 GLY GLY B . n 
B 1 490 VAL 490 448 448 VAL VAL B . n 
B 1 491 ASN 491 449 449 ASN ASN B . n 
B 1 492 SER 492 450 450 SER SER B . n 
B 1 493 ASP 493 451 451 ASP ASP B . n 
B 1 494 THR 494 452 452 THR THR B . n 
B 1 495 VAL 495 453 453 VAL VAL B . n 
B 1 496 GLY 496 454 454 GLY GLY B . n 
B 1 497 TRP 497 455 455 TRP TRP B . n 
B 1 498 SER 498 456 456 SER SER B . n 
B 1 499 TRP 499 457 457 TRP TRP B . n 
B 1 500 PRO 500 458 458 PRO PRO B . n 
B 1 501 ASP 501 459 459 ASP ASP B . n 
B 1 502 GLY 502 460 460 GLY GLY B . n 
B 1 503 ALA 503 461 461 ALA ALA B . n 
B 1 504 GLU 504 462 462 GLU GLU B . n 
B 1 505 LEU 505 463 463 LEU LEU B . n 
B 1 506 PRO 506 464 464 PRO PRO B . n 
B 1 507 PHE 507 465 465 PHE PHE B . n 
B 1 508 THR 508 466 466 THR THR B . n 
B 1 509 ILE 509 467 467 ILE ILE B . n 
B 1 510 ASP 510 468 468 ASP ASP B . n 
B 1 511 LYS 511 469 469 LYS LYS B . n 
# 
loop_
_pdbx_branch_scheme.asym_id 
_pdbx_branch_scheme.entity_id 
_pdbx_branch_scheme.mon_id 
_pdbx_branch_scheme.num 
_pdbx_branch_scheme.pdb_asym_id 
_pdbx_branch_scheme.pdb_mon_id 
_pdbx_branch_scheme.pdb_seq_num 
_pdbx_branch_scheme.auth_asym_id 
_pdbx_branch_scheme.auth_mon_id 
_pdbx_branch_scheme.auth_seq_num 
_pdbx_branch_scheme.hetero 
C 2 NAG 1 C NAG 1 A NAG 504 n 
C 2 NAG 2 C NAG 2 A NAG 505 n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 CA  ? ? CA  ? ? 'SUBJECT OF INVESTIGATION' ? 
2 NAG ? ? NAG ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
D 3 CA  1   500 500   CA  CA  A . 
E 3 CA  1   501 501   CA  CA  A . 
F 4 NAG 1   502 502   NAG NAG A . 
G 4 NAG 1   503 503   NAG NAG A . 
H 3 CA  1   500 500   CA  CA  B . 
I 3 CA  1   501 501   CA  CA  B . 
J 4 NAG 1   502 502   NAG NAG B . 
K 4 NAG 1   503 503   NAG NAG B . 
L 4 NAG 1   504 504   NAG NAG B . 
M 5 HOH 1   601 488   HOH HOH A . 
M 5 HOH 2   602 687   HOH HOH A . 
M 5 HOH 3   603 9607  HOH HOH A . 
M 5 HOH 4   604 4282  HOH HOH A . 
M 5 HOH 5   605 113   HOH HOH A . 
M 5 HOH 6   606 1804  HOH HOH A . 
M 5 HOH 7   607 1216  HOH HOH A . 
M 5 HOH 8   608 271   HOH HOH A . 
M 5 HOH 9   609 249   HOH HOH A . 
M 5 HOH 10  610 63    HOH HOH A . 
M 5 HOH 11  611 951   HOH HOH A . 
M 5 HOH 12  612 391   HOH HOH A . 
M 5 HOH 13  613 1395  HOH HOH A . 
M 5 HOH 14  614 1046  HOH HOH A . 
M 5 HOH 15  615 483   HOH HOH A . 
M 5 HOH 16  616 39    HOH HOH A . 
M 5 HOH 17  617 701   HOH HOH A . 
M 5 HOH 18  618 235   HOH HOH A . 
M 5 HOH 19  619 118   HOH HOH A . 
M 5 HOH 20  620 8757  HOH HOH A . 
M 5 HOH 21  621 4556  HOH HOH A . 
M 5 HOH 22  622 182   HOH HOH A . 
M 5 HOH 23  623 476   HOH HOH A . 
M 5 HOH 24  624 3     HOH HOH A . 
M 5 HOH 25  625 822   HOH HOH A . 
M 5 HOH 26  626 5224  HOH HOH A . 
M 5 HOH 27  627 34    HOH HOH A . 
M 5 HOH 28  628 21    HOH HOH A . 
M 5 HOH 29  629 7917  HOH HOH A . 
M 5 HOH 30  630 963   HOH HOH A . 
M 5 HOH 31  631 23    HOH HOH A . 
M 5 HOH 32  632 8888  HOH HOH A . 
M 5 HOH 33  633 489   HOH HOH A . 
M 5 HOH 34  634 2     HOH HOH A . 
M 5 HOH 35  635 755   HOH HOH A . 
M 5 HOH 36  636 291   HOH HOH A . 
M 5 HOH 37  637 1254  HOH HOH A . 
M 5 HOH 38  638 293   HOH HOH A . 
M 5 HOH 39  639 205   HOH HOH A . 
M 5 HOH 40  640 38    HOH HOH A . 
M 5 HOH 41  641 28    HOH HOH A . 
M 5 HOH 42  642 27    HOH HOH A . 
M 5 HOH 43  643 356   HOH HOH A . 
M 5 HOH 44  644 4384  HOH HOH A . 
M 5 HOH 45  645 14    HOH HOH A . 
M 5 HOH 46  646 223   HOH HOH A . 
M 5 HOH 47  647 6924  HOH HOH A . 
M 5 HOH 48  648 990   HOH HOH A . 
M 5 HOH 49  649 8238  HOH HOH A . 
M 5 HOH 50  650 389   HOH HOH A . 
M 5 HOH 51  651 838   HOH HOH A . 
M 5 HOH 52  652 385   HOH HOH A . 
M 5 HOH 53  653 970   HOH HOH A . 
M 5 HOH 54  654 473   HOH HOH A . 
M 5 HOH 55  655 581   HOH HOH A . 
M 5 HOH 56  656 4305  HOH HOH A . 
M 5 HOH 57  657 647   HOH HOH A . 
M 5 HOH 58  658 377   HOH HOH A . 
M 5 HOH 59  659 341   HOH HOH A . 
M 5 HOH 60  660 6921  HOH HOH A . 
M 5 HOH 61  661 10252 HOH HOH A . 
M 5 HOH 62  662 191   HOH HOH A . 
M 5 HOH 63  663 121   HOH HOH A . 
M 5 HOH 64  664 459   HOH HOH A . 
M 5 HOH 65  665 157   HOH HOH A . 
M 5 HOH 66  666 51    HOH HOH A . 
M 5 HOH 67  667 283   HOH HOH A . 
M 5 HOH 68  668 3948  HOH HOH A . 
M 5 HOH 69  669 105   HOH HOH A . 
M 5 HOH 70  670 1007  HOH HOH A . 
M 5 HOH 71  671 11568 HOH HOH A . 
M 5 HOH 72  672 280   HOH HOH A . 
M 5 HOH 73  673 212   HOH HOH A . 
M 5 HOH 74  674 270   HOH HOH A . 
M 5 HOH 75  675 66    HOH HOH A . 
M 5 HOH 76  676 4516  HOH HOH A . 
M 5 HOH 77  677 9     HOH HOH A . 
M 5 HOH 78  678 141   HOH HOH A . 
M 5 HOH 79  679 207   HOH HOH A . 
M 5 HOH 80  680 54    HOH HOH A . 
M 5 HOH 81  681 55    HOH HOH A . 
M 5 HOH 82  682 259   HOH HOH A . 
M 5 HOH 83  683 215   HOH HOH A . 
M 5 HOH 84  684 8     HOH HOH A . 
M 5 HOH 85  685 120   HOH HOH A . 
M 5 HOH 86  686 117   HOH HOH A . 
M 5 HOH 87  687 480   HOH HOH A . 
M 5 HOH 88  688 267   HOH HOH A . 
M 5 HOH 89  689 145   HOH HOH A . 
M 5 HOH 90  690 264   HOH HOH A . 
M 5 HOH 91  691 147   HOH HOH A . 
M 5 HOH 92  692 204   HOH HOH A . 
M 5 HOH 93  693 895   HOH HOH A . 
M 5 HOH 94  694 912   HOH HOH A . 
M 5 HOH 95  695 897   HOH HOH A . 
M 5 HOH 96  696 1883  HOH HOH A . 
M 5 HOH 97  697 1215  HOH HOH A . 
M 5 HOH 98  698 73    HOH HOH A . 
M 5 HOH 99  699 101   HOH HOH A . 
M 5 HOH 100 700 111   HOH HOH A . 
M 5 HOH 101 701 52    HOH HOH A . 
M 5 HOH 102 702 180   HOH HOH A . 
M 5 HOH 103 703 343   HOH HOH A . 
M 5 HOH 104 704 6     HOH HOH A . 
M 5 HOH 105 705 775   HOH HOH A . 
M 5 HOH 106 706 11    HOH HOH A . 
M 5 HOH 107 707 45    HOH HOH A . 
M 5 HOH 108 708 92    HOH HOH A . 
M 5 HOH 109 709 2914  HOH HOH A . 
M 5 HOH 110 710 69    HOH HOH A . 
M 5 HOH 111 711 699   HOH HOH A . 
M 5 HOH 112 712 321   HOH HOH A . 
M 5 HOH 113 713 110   HOH HOH A . 
M 5 HOH 114 714 87    HOH HOH A . 
M 5 HOH 115 715 266   HOH HOH A . 
M 5 HOH 116 716 78    HOH HOH A . 
M 5 HOH 117 717 4573  HOH HOH A . 
M 5 HOH 118 718 158   HOH HOH A . 
M 5 HOH 119 719 1780  HOH HOH A . 
M 5 HOH 120 720 418   HOH HOH A . 
M 5 HOH 121 721 4550  HOH HOH A . 
M 5 HOH 122 722 65    HOH HOH A . 
M 5 HOH 123 723 59    HOH HOH A . 
M 5 HOH 124 724 42    HOH HOH A . 
M 5 HOH 125 725 132   HOH HOH A . 
M 5 HOH 126 726 174   HOH HOH A . 
M 5 HOH 127 727 168   HOH HOH A . 
M 5 HOH 128 728 499   HOH HOH A . 
M 5 HOH 129 729 49    HOH HOH A . 
M 5 HOH 130 730 5954  HOH HOH A . 
M 5 HOH 131 731 256   HOH HOH A . 
M 5 HOH 132 732 998   HOH HOH A . 
M 5 HOH 133 733 314   HOH HOH A . 
M 5 HOH 134 734 509   HOH HOH A . 
M 5 HOH 135 735 164   HOH HOH A . 
M 5 HOH 136 736 825   HOH HOH A . 
M 5 HOH 137 737 1988  HOH HOH A . 
M 5 HOH 138 738 4281  HOH HOH A . 
M 5 HOH 139 739 177   HOH HOH A . 
M 5 HOH 140 740 244   HOH HOH A . 
M 5 HOH 141 741 1476  HOH HOH A . 
M 5 HOH 142 742 5202  HOH HOH A . 
M 5 HOH 143 743 1051  HOH HOH A . 
M 5 HOH 144 744 250   HOH HOH A . 
M 5 HOH 145 745 71    HOH HOH A . 
M 5 HOH 146 746 7946  HOH HOH A . 
M 5 HOH 147 747 547   HOH HOH A . 
M 5 HOH 148 748 568   HOH HOH A . 
M 5 HOH 149 749 263   HOH HOH A . 
M 5 HOH 150 750 241   HOH HOH A . 
M 5 HOH 151 751 196   HOH HOH A . 
M 5 HOH 152 752 636   HOH HOH A . 
M 5 HOH 153 753 5364  HOH HOH A . 
M 5 HOH 154 754 310   HOH HOH A . 
M 5 HOH 155 755 1517  HOH HOH A . 
M 5 HOH 156 756 992   HOH HOH A . 
M 5 HOH 157 757 58    HOH HOH A . 
M 5 HOH 158 758 689   HOH HOH A . 
M 5 HOH 159 759 194   HOH HOH A . 
M 5 HOH 160 760 813   HOH HOH A . 
M 5 HOH 161 761 91    HOH HOH A . 
M 5 HOH 162 762 434   HOH HOH A . 
M 5 HOH 163 763 733   HOH HOH A . 
M 5 HOH 164 764 201   HOH HOH A . 
M 5 HOH 165 765 382   HOH HOH A . 
M 5 HOH 166 766 98    HOH HOH A . 
M 5 HOH 167 767 540   HOH HOH A . 
M 5 HOH 168 768 1280  HOH HOH A . 
M 5 HOH 169 769 85    HOH HOH A . 
M 5 HOH 170 770 4367  HOH HOH A . 
M 5 HOH 171 771 248   HOH HOH A . 
M 5 HOH 172 772 872   HOH HOH A . 
M 5 HOH 173 773 276   HOH HOH A . 
M 5 HOH 174 774 4279  HOH HOH A . 
M 5 HOH 175 775 4919  HOH HOH A . 
M 5 HOH 176 776 469   HOH HOH A . 
M 5 HOH 177 777 6031  HOH HOH A . 
M 5 HOH 178 778 519   HOH HOH A . 
M 5 HOH 179 779 357   HOH HOH A . 
M 5 HOH 180 780 287   HOH HOH A . 
M 5 HOH 181 781 134   HOH HOH A . 
M 5 HOH 182 782 100   HOH HOH A . 
M 5 HOH 183 783 633   HOH HOH A . 
M 5 HOH 184 784 119   HOH HOH A . 
M 5 HOH 185 785 1062  HOH HOH A . 
M 5 HOH 186 786 5611  HOH HOH A . 
M 5 HOH 187 787 1057  HOH HOH A . 
M 5 HOH 188 788 1045  HOH HOH A . 
M 5 HOH 189 789 26    HOH HOH A . 
M 5 HOH 190 790 148   HOH HOH A . 
M 5 HOH 191 791 2057  HOH HOH A . 
M 5 HOH 192 792 192   HOH HOH A . 
M 5 HOH 193 793 9380  HOH HOH A . 
M 5 HOH 194 794 176   HOH HOH A . 
M 5 HOH 195 795 1589  HOH HOH A . 
M 5 HOH 196 796 355   HOH HOH A . 
M 5 HOH 197 797 251   HOH HOH A . 
M 5 HOH 198 798 171   HOH HOH A . 
M 5 HOH 199 799 582   HOH HOH A . 
M 5 HOH 200 800 95    HOH HOH A . 
M 5 HOH 201 801 9241  HOH HOH A . 
M 5 HOH 202 802 799   HOH HOH A . 
M 5 HOH 203 803 867   HOH HOH A . 
M 5 HOH 204 804 83    HOH HOH A . 
M 5 HOH 205 805 304   HOH HOH A . 
M 5 HOH 206 806 722   HOH HOH A . 
M 5 HOH 207 807 713   HOH HOH A . 
M 5 HOH 208 808 53    HOH HOH A . 
M 5 HOH 209 809 156   HOH HOH A . 
M 5 HOH 210 810 869   HOH HOH A . 
M 5 HOH 211 811 315   HOH HOH A . 
M 5 HOH 212 812 6021  HOH HOH A . 
M 5 HOH 213 813 705   HOH HOH A . 
M 5 HOH 214 814 1300  HOH HOH A . 
M 5 HOH 215 815 221   HOH HOH A . 
M 5 HOH 216 816 237   HOH HOH A . 
M 5 HOH 217 817 1482  HOH HOH A . 
M 5 HOH 218 818 146   HOH HOH A . 
M 5 HOH 219 819 948   HOH HOH A . 
M 5 HOH 220 820 130   HOH HOH A . 
M 5 HOH 221 821 97    HOH HOH A . 
M 5 HOH 222 822 20    HOH HOH A . 
M 5 HOH 223 823 313   HOH HOH A . 
M 5 HOH 224 824 1503  HOH HOH A . 
M 5 HOH 225 825 123   HOH HOH A . 
M 5 HOH 226 826 3551  HOH HOH A . 
M 5 HOH 227 827 288   HOH HOH A . 
M 5 HOH 228 828 574   HOH HOH A . 
M 5 HOH 229 829 231   HOH HOH A . 
M 5 HOH 230 830 2077  HOH HOH A . 
M 5 HOH 231 831 746   HOH HOH A . 
M 5 HOH 232 832 323   HOH HOH A . 
M 5 HOH 233 833 979   HOH HOH A . 
M 5 HOH 234 834 7425  HOH HOH A . 
M 5 HOH 235 835 1367  HOH HOH A . 
M 5 HOH 236 836 3897  HOH HOH A . 
M 5 HOH 237 837 384   HOH HOH A . 
M 5 HOH 238 838 390   HOH HOH A . 
M 5 HOH 239 839 5134  HOH HOH A . 
M 5 HOH 240 840 587   HOH HOH A . 
M 5 HOH 241 841 80    HOH HOH A . 
M 5 HOH 242 842 1079  HOH HOH A . 
M 5 HOH 243 843 160   HOH HOH A . 
M 5 HOH 244 844 103   HOH HOH A . 
M 5 HOH 245 845 727   HOH HOH A . 
M 5 HOH 246 846 5461  HOH HOH A . 
M 5 HOH 247 847 198   HOH HOH A . 
M 5 HOH 248 848 657   HOH HOH A . 
M 5 HOH 249 849 257   HOH HOH A . 
M 5 HOH 250 850 2459  HOH HOH A . 
M 5 HOH 251 851 193   HOH HOH A . 
M 5 HOH 252 852 225   HOH HOH A . 
M 5 HOH 253 853 628   HOH HOH A . 
M 5 HOH 254 854 1024  HOH HOH A . 
M 5 HOH 255 855 481   HOH HOH A . 
M 5 HOH 256 856 239   HOH HOH A . 
M 5 HOH 257 857 4543  HOH HOH A . 
M 5 HOH 258 858 576   HOH HOH A . 
M 5 HOH 259 859 1773  HOH HOH A . 
M 5 HOH 260 860 2075  HOH HOH A . 
M 5 HOH 261 861 4703  HOH HOH A . 
M 5 HOH 262 862 6638  HOH HOH A . 
M 5 HOH 263 863 4836  HOH HOH A . 
M 5 HOH 264 864 1188  HOH HOH A . 
M 5 HOH 265 865 745   HOH HOH A . 
M 5 HOH 266 866 383   HOH HOH A . 
M 5 HOH 267 867 4453  HOH HOH A . 
M 5 HOH 268 868 211   HOH HOH A . 
M 5 HOH 269 869 322   HOH HOH A . 
M 5 HOH 270 870 830   HOH HOH A . 
M 5 HOH 271 871 3206  HOH HOH A . 
M 5 HOH 272 872 4299  HOH HOH A . 
M 5 HOH 273 873 4307  HOH HOH A . 
M 5 HOH 274 874 4326  HOH HOH A . 
M 5 HOH 275 875 4754  HOH HOH A . 
M 5 HOH 276 876 5019  HOH HOH A . 
M 5 HOH 277 877 4052  HOH HOH A . 
M 5 HOH 278 878 1177  HOH HOH A . 
M 5 HOH 279 879 6218  HOH HOH A . 
M 5 HOH 280 880 1893  HOH HOH A . 
M 5 HOH 281 881 9312  HOH HOH A . 
M 5 HOH 282 882 8102  HOH HOH A . 
M 5 HOH 283 883 852   HOH HOH A . 
M 5 HOH 284 884 4674  HOH HOH A . 
M 5 HOH 285 885 1179  HOH HOH A . 
M 5 HOH 286 886 1555  HOH HOH A . 
M 5 HOH 287 887 4379  HOH HOH A . 
M 5 HOH 288 888 5584  HOH HOH A . 
M 5 HOH 289 889 7896  HOH HOH A . 
M 5 HOH 290 890 1060  HOH HOH A . 
M 5 HOH 291 891 11370 HOH HOH A . 
M 5 HOH 292 892 1225  HOH HOH A . 
M 5 HOH 293 893 8182  HOH HOH A . 
M 5 HOH 294 894 1067  HOH HOH A . 
M 5 HOH 295 895 5546  HOH HOH A . 
M 5 HOH 296 896 303   HOH HOH A . 
M 5 HOH 297 897 7334  HOH HOH A . 
M 5 HOH 298 898 4339  HOH HOH A . 
M 5 HOH 299 899 6226  HOH HOH A . 
M 5 HOH 300 900 973   HOH HOH A . 
M 5 HOH 301 901 523   HOH HOH A . 
M 5 HOH 302 902 7424  HOH HOH A . 
M 5 HOH 303 903 6194  HOH HOH A . 
M 5 HOH 304 904 777   HOH HOH A . 
M 5 HOH 305 905 9216  HOH HOH A . 
M 5 HOH 306 906 2256  HOH HOH A . 
M 5 HOH 307 907 4760  HOH HOH A . 
M 5 HOH 308 908 1359  HOH HOH A . 
M 5 HOH 309 909 3026  HOH HOH A . 
M 5 HOH 310 910 907   HOH HOH A . 
M 5 HOH 311 911 975   HOH HOH A . 
M 5 HOH 312 912 2750  HOH HOH A . 
M 5 HOH 313 913 8204  HOH HOH A . 
M 5 HOH 314 914 670   HOH HOH A . 
M 5 HOH 315 915 465   HOH HOH A . 
M 5 HOH 316 916 10452 HOH HOH A . 
M 5 HOH 317 917 333   HOH HOH A . 
M 5 HOH 318 918 4314  HOH HOH A . 
M 5 HOH 319 919 761   HOH HOH A . 
M 5 HOH 320 920 847   HOH HOH A . 
M 5 HOH 321 921 5005  HOH HOH A . 
M 5 HOH 322 922 1023  HOH HOH A . 
M 5 HOH 323 923 2562  HOH HOH A . 
M 5 HOH 324 924 678   HOH HOH A . 
M 5 HOH 325 925 456   HOH HOH A . 
M 5 HOH 326 926 7248  HOH HOH A . 
M 5 HOH 327 927 4416  HOH HOH A . 
M 5 HOH 328 928 8447  HOH HOH A . 
M 5 HOH 329 929 855   HOH HOH A . 
M 5 HOH 330 930 804   HOH HOH A . 
M 5 HOH 331 931 928   HOH HOH A . 
M 5 HOH 332 932 1284  HOH HOH A . 
M 5 HOH 333 933 5744  HOH HOH A . 
M 5 HOH 334 934 7932  HOH HOH A . 
M 5 HOH 335 935 162   HOH HOH A . 
M 5 HOH 336 936 6435  HOH HOH A . 
M 5 HOH 337 937 885   HOH HOH A . 
M 5 HOH 338 938 709   HOH HOH A . 
M 5 HOH 339 939 5254  HOH HOH A . 
M 5 HOH 340 940 3447  HOH HOH A . 
M 5 HOH 341 941 1673  HOH HOH A . 
M 5 HOH 342 942 11076 HOH HOH A . 
M 5 HOH 343 943 2145  HOH HOH A . 
M 5 HOH 344 944 889   HOH HOH A . 
M 5 HOH 345 945 4946  HOH HOH A . 
M 5 HOH 346 946 718   HOH HOH A . 
M 5 HOH 347 947 10684 HOH HOH A . 
M 5 HOH 348 948 4514  HOH HOH A . 
M 5 HOH 349 949 1008  HOH HOH A . 
M 5 HOH 350 950 2532  HOH HOH A . 
M 5 HOH 351 951 6314  HOH HOH A . 
M 5 HOH 352 952 2427  HOH HOH A . 
M 5 HOH 353 953 4471  HOH HOH A . 
M 5 HOH 354 954 8418  HOH HOH A . 
M 5 HOH 355 955 8546  HOH HOH A . 
M 5 HOH 356 956 8354  HOH HOH A . 
M 5 HOH 357 957 6264  HOH HOH A . 
N 5 HOH 1   601 4284  HOH HOH B . 
N 5 HOH 2   602 4395  HOH HOH B . 
N 5 HOH 3   603 297   HOH HOH B . 
N 5 HOH 4   604 1168  HOH HOH B . 
N 5 HOH 5   605 195   HOH HOH B . 
N 5 HOH 6   606 656   HOH HOH B . 
N 5 HOH 7   607 650   HOH HOH B . 
N 5 HOH 8   608 61    HOH HOH B . 
N 5 HOH 9   609 4351  HOH HOH B . 
N 5 HOH 10  610 5     HOH HOH B . 
N 5 HOH 11  611 238   HOH HOH B . 
N 5 HOH 12  612 342   HOH HOH B . 
N 5 HOH 13  613 60    HOH HOH B . 
N 5 HOH 14  614 504   HOH HOH B . 
N 5 HOH 15  615 220   HOH HOH B . 
N 5 HOH 16  616 682   HOH HOH B . 
N 5 HOH 17  617 40    HOH HOH B . 
N 5 HOH 18  618 56    HOH HOH B . 
N 5 HOH 19  619 3065  HOH HOH B . 
N 5 HOH 20  620 371   HOH HOH B . 
N 5 HOH 21  621 677   HOH HOH B . 
N 5 HOH 22  622 693   HOH HOH B . 
N 5 HOH 23  623 886   HOH HOH B . 
N 5 HOH 24  624 1343  HOH HOH B . 
N 5 HOH 25  625 8427  HOH HOH B . 
N 5 HOH 26  626 67    HOH HOH B . 
N 5 HOH 27  627 217   HOH HOH B . 
N 5 HOH 28  628 29    HOH HOH B . 
N 5 HOH 29  629 4285  HOH HOH B . 
N 5 HOH 30  630 227   HOH HOH B . 
N 5 HOH 31  631 965   HOH HOH B . 
N 5 HOH 32  632 155   HOH HOH B . 
N 5 HOH 33  633 1444  HOH HOH B . 
N 5 HOH 34  634 4288  HOH HOH B . 
N 5 HOH 35  635 1013  HOH HOH B . 
N 5 HOH 36  636 17    HOH HOH B . 
N 5 HOH 37  637 518   HOH HOH B . 
N 5 HOH 38  638 46    HOH HOH B . 
N 5 HOH 39  639 187   HOH HOH B . 
N 5 HOH 40  640 515   HOH HOH B . 
N 5 HOH 41  641 149   HOH HOH B . 
N 5 HOH 42  642 252   HOH HOH B . 
N 5 HOH 43  643 62    HOH HOH B . 
N 5 HOH 44  644 24    HOH HOH B . 
N 5 HOH 45  645 143   HOH HOH B . 
N 5 HOH 46  646 1427  HOH HOH B . 
N 5 HOH 47  647 625   HOH HOH B . 
N 5 HOH 48  648 138   HOH HOH B . 
N 5 HOH 49  649 25    HOH HOH B . 
N 5 HOH 50  650 169   HOH HOH B . 
N 5 HOH 51  651 159   HOH HOH B . 
N 5 HOH 52  652 16    HOH HOH B . 
N 5 HOH 53  653 89    HOH HOH B . 
N 5 HOH 54  654 84    HOH HOH B . 
N 5 HOH 55  655 370   HOH HOH B . 
N 5 HOH 56  656 1262  HOH HOH B . 
N 5 HOH 57  657 1410  HOH HOH B . 
N 5 HOH 58  658 589   HOH HOH B . 
N 5 HOH 59  659 213   HOH HOH B . 
N 5 HOH 60  660 7897  HOH HOH B . 
N 5 HOH 61  661 33    HOH HOH B . 
N 5 HOH 62  662 330   HOH HOH B . 
N 5 HOH 63  663 366   HOH HOH B . 
N 5 HOH 64  664 122   HOH HOH B . 
N 5 HOH 65  665 801   HOH HOH B . 
N 5 HOH 66  666 802   HOH HOH B . 
N 5 HOH 67  667 112   HOH HOH B . 
N 5 HOH 68  668 367   HOH HOH B . 
N 5 HOH 69  669 203   HOH HOH B . 
N 5 HOH 70  670 277   HOH HOH B . 
N 5 HOH 71  671 819   HOH HOH B . 
N 5 HOH 72  672 41    HOH HOH B . 
N 5 HOH 73  673 82    HOH HOH B . 
N 5 HOH 74  674 12    HOH HOH B . 
N 5 HOH 75  675 197   HOH HOH B . 
N 5 HOH 76  676 142   HOH HOH B . 
N 5 HOH 77  677 131   HOH HOH B . 
N 5 HOH 78  678 170   HOH HOH B . 
N 5 HOH 79  679 8876  HOH HOH B . 
N 5 HOH 80  680 696   HOH HOH B . 
N 5 HOH 81  681 629   HOH HOH B . 
N 5 HOH 82  682 1366  HOH HOH B . 
N 5 HOH 83  683 88    HOH HOH B . 
N 5 HOH 84  684 31    HOH HOH B . 
N 5 HOH 85  685 226   HOH HOH B . 
N 5 HOH 86  686 94    HOH HOH B . 
N 5 HOH 87  687 411   HOH HOH B . 
N 5 HOH 88  688 48    HOH HOH B . 
N 5 HOH 89  689 6002  HOH HOH B . 
N 5 HOH 90  690 209   HOH HOH B . 
N 5 HOH 91  691 64    HOH HOH B . 
N 5 HOH 92  692 242   HOH HOH B . 
N 5 HOH 93  693 3425  HOH HOH B . 
N 5 HOH 94  694 7     HOH HOH B . 
N 5 HOH 95  695 93    HOH HOH B . 
N 5 HOH 96  696 784   HOH HOH B . 
N 5 HOH 97  697 173   HOH HOH B . 
N 5 HOH 98  698 234   HOH HOH B . 
N 5 HOH 99  699 1269  HOH HOH B . 
N 5 HOH 100 700 30    HOH HOH B . 
N 5 HOH 101 701 4293  HOH HOH B . 
N 5 HOH 102 702 9792  HOH HOH B . 
N 5 HOH 103 703 400   HOH HOH B . 
N 5 HOH 104 704 22    HOH HOH B . 
N 5 HOH 105 705 43    HOH HOH B . 
N 5 HOH 106 706 1331  HOH HOH B . 
N 5 HOH 107 707 81    HOH HOH B . 
N 5 HOH 108 708 923   HOH HOH B . 
N 5 HOH 109 709 1246  HOH HOH B . 
N 5 HOH 110 710 1381  HOH HOH B . 
N 5 HOH 111 711 527   HOH HOH B . 
N 5 HOH 112 712 11516 HOH HOH B . 
N 5 HOH 113 713 4990  HOH HOH B . 
N 5 HOH 114 714 37    HOH HOH B . 
N 5 HOH 115 715 137   HOH HOH B . 
N 5 HOH 116 716 18    HOH HOH B . 
N 5 HOH 117 717 216   HOH HOH B . 
N 5 HOH 118 718 108   HOH HOH B . 
N 5 HOH 119 719 5295  HOH HOH B . 
N 5 HOH 120 720 317   HOH HOH B . 
N 5 HOH 121 721 399   HOH HOH B . 
N 5 HOH 122 722 694   HOH HOH B . 
N 5 HOH 123 723 1419  HOH HOH B . 
N 5 HOH 124 724 490   HOH HOH B . 
N 5 HOH 125 725 36    HOH HOH B . 
N 5 HOH 126 726 4     HOH HOH B . 
N 5 HOH 127 727 337   HOH HOH B . 
N 5 HOH 128 728 79    HOH HOH B . 
N 5 HOH 129 729 144   HOH HOH B . 
N 5 HOH 130 730 190   HOH HOH B . 
N 5 HOH 131 731 350   HOH HOH B . 
N 5 HOH 132 732 345   HOH HOH B . 
N 5 HOH 133 733 796   HOH HOH B . 
N 5 HOH 134 734 96    HOH HOH B . 
N 5 HOH 135 735 140   HOH HOH B . 
N 5 HOH 136 736 332   HOH HOH B . 
N 5 HOH 137 737 57    HOH HOH B . 
N 5 HOH 138 738 210   HOH HOH B . 
N 5 HOH 139 739 752   HOH HOH B . 
N 5 HOH 140 740 285   HOH HOH B . 
N 5 HOH 141 741 219   HOH HOH B . 
N 5 HOH 142 742 525   HOH HOH B . 
N 5 HOH 143 743 417   HOH HOH B . 
N 5 HOH 144 744 697   HOH HOH B . 
N 5 HOH 145 745 435   HOH HOH B . 
N 5 HOH 146 746 941   HOH HOH B . 
N 5 HOH 147 747 269   HOH HOH B . 
N 5 HOH 148 748 2204  HOH HOH B . 
N 5 HOH 149 749 1723  HOH HOH B . 
N 5 HOH 150 750 437   HOH HOH B . 
N 5 HOH 151 751 133   HOH HOH B . 
N 5 HOH 152 752 700   HOH HOH B . 
N 5 HOH 153 753 334   HOH HOH B . 
N 5 HOH 154 754 649   HOH HOH B . 
N 5 HOH 155 755 4983  HOH HOH B . 
N 5 HOH 156 756 2121  HOH HOH B . 
N 5 HOH 157 757 107   HOH HOH B . 
N 5 HOH 158 758 68    HOH HOH B . 
N 5 HOH 159 759 1516  HOH HOH B . 
N 5 HOH 160 760 75    HOH HOH B . 
N 5 HOH 161 761 552   HOH HOH B . 
N 5 HOH 162 762 229   HOH HOH B . 
N 5 HOH 163 763 175   HOH HOH B . 
N 5 HOH 164 764 9795  HOH HOH B . 
N 5 HOH 165 765 841   HOH HOH B . 
N 5 HOH 166 766 178   HOH HOH B . 
N 5 HOH 167 767 4864  HOH HOH B . 
N 5 HOH 168 768 102   HOH HOH B . 
N 5 HOH 169 769 32    HOH HOH B . 
N 5 HOH 170 770 387   HOH HOH B . 
N 5 HOH 171 771 306   HOH HOH B . 
N 5 HOH 172 772 461   HOH HOH B . 
N 5 HOH 173 773 1197  HOH HOH B . 
N 5 HOH 174 774 426   HOH HOH B . 
N 5 HOH 175 775 3618  HOH HOH B . 
N 5 HOH 176 776 116   HOH HOH B . 
N 5 HOH 177 777 161   HOH HOH B . 
N 5 HOH 178 778 265   HOH HOH B . 
N 5 HOH 179 779 70    HOH HOH B . 
N 5 HOH 180 780 324   HOH HOH B . 
N 5 HOH 181 781 857   HOH HOH B . 
N 5 HOH 182 782 5261  HOH HOH B . 
N 5 HOH 183 783 854   HOH HOH B . 
N 5 HOH 184 784 4838  HOH HOH B . 
N 5 HOH 185 785 1473  HOH HOH B . 
N 5 HOH 186 786 711   HOH HOH B . 
N 5 HOH 187 787 104   HOH HOH B . 
N 5 HOH 188 788 749   HOH HOH B . 
N 5 HOH 189 789 731   HOH HOH B . 
N 5 HOH 190 790 208   HOH HOH B . 
N 5 HOH 191 791 1101  HOH HOH B . 
N 5 HOH 192 792 7651  HOH HOH B . 
N 5 HOH 193 793 329   HOH HOH B . 
N 5 HOH 194 794 106   HOH HOH B . 
N 5 HOH 195 795 9566  HOH HOH B . 
N 5 HOH 196 796 4304  HOH HOH B . 
N 5 HOH 197 797 352   HOH HOH B . 
N 5 HOH 198 798 47    HOH HOH B . 
N 5 HOH 199 799 139   HOH HOH B . 
N 5 HOH 200 800 299   HOH HOH B . 
N 5 HOH 201 801 676   HOH HOH B . 
N 5 HOH 202 802 1076  HOH HOH B . 
N 5 HOH 203 803 2320  HOH HOH B . 
N 5 HOH 204 804 245   HOH HOH B . 
N 5 HOH 205 805 74    HOH HOH B . 
N 5 HOH 206 806 261   HOH HOH B . 
N 5 HOH 207 807 1211  HOH HOH B . 
N 5 HOH 208 808 395   HOH HOH B . 
N 5 HOH 209 809 76    HOH HOH B . 
N 5 HOH 210 810 326   HOH HOH B . 
N 5 HOH 211 811 567   HOH HOH B . 
N 5 HOH 212 812 349   HOH HOH B . 
N 5 HOH 213 813 6353  HOH HOH B . 
N 5 HOH 214 814 721   HOH HOH B . 
N 5 HOH 215 815 10    HOH HOH B . 
N 5 HOH 216 816 86    HOH HOH B . 
N 5 HOH 217 817 5835  HOH HOH B . 
N 5 HOH 218 818 6249  HOH HOH B . 
N 5 HOH 219 819 8874  HOH HOH B . 
N 5 HOH 220 820 406   HOH HOH B . 
N 5 HOH 221 821 298   HOH HOH B . 
N 5 HOH 222 822 4383  HOH HOH B . 
N 5 HOH 223 823 279   HOH HOH B . 
N 5 HOH 224 824 5000  HOH HOH B . 
N 5 HOH 225 825 810   HOH HOH B . 
N 5 HOH 226 826 526   HOH HOH B . 
N 5 HOH 227 827 503   HOH HOH B . 
N 5 HOH 228 828 253   HOH HOH B . 
N 5 HOH 229 829 7938  HOH HOH B . 
N 5 HOH 230 830 10588 HOH HOH B . 
N 5 HOH 231 831 1075  HOH HOH B . 
N 5 HOH 232 832 734   HOH HOH B . 
N 5 HOH 233 833 1560  HOH HOH B . 
N 5 HOH 234 834 232   HOH HOH B . 
N 5 HOH 235 835 3297  HOH HOH B . 
N 5 HOH 236 836 3339  HOH HOH B . 
N 5 HOH 237 837 9560  HOH HOH B . 
N 5 HOH 238 838 8509  HOH HOH B . 
N 5 HOH 239 839 805   HOH HOH B . 
N 5 HOH 240 840 1352  HOH HOH B . 
N 5 HOH 241 841 188   HOH HOH B . 
N 5 HOH 242 842 729   HOH HOH B . 
N 5 HOH 243 843 11430 HOH HOH B . 
N 5 HOH 244 844 4381  HOH HOH B . 
N 5 HOH 245 845 1118  HOH HOH B . 
N 5 HOH 246 846 683   HOH HOH B . 
N 5 HOH 247 847 3527  HOH HOH B . 
N 5 HOH 248 848 1791  HOH HOH B . 
N 5 HOH 249 849 9144  HOH HOH B . 
N 5 HOH 250 850 487   HOH HOH B . 
N 5 HOH 251 851 13    HOH HOH B . 
N 5 HOH 252 852 5944  HOH HOH B . 
N 5 HOH 253 853 331   HOH HOH B . 
N 5 HOH 254 854 728   HOH HOH B . 
N 5 HOH 255 855 621   HOH HOH B . 
N 5 HOH 256 856 4677  HOH HOH B . 
N 5 HOH 257 857 5201  HOH HOH B . 
N 5 HOH 258 858 10102 HOH HOH B . 
N 5 HOH 259 859 4797  HOH HOH B . 
N 5 HOH 260 860 1250  HOH HOH B . 
N 5 HOH 261 861 2787  HOH HOH B . 
N 5 HOH 262 862 2912  HOH HOH B . 
N 5 HOH 263 863 8565  HOH HOH B . 
N 5 HOH 264 864 6183  HOH HOH B . 
N 5 HOH 265 865 4964  HOH HOH B . 
N 5 HOH 266 866 1030  HOH HOH B . 
N 5 HOH 267 867 4354  HOH HOH B . 
N 5 HOH 268 868 1125  HOH HOH B . 
N 5 HOH 269 869 767   HOH HOH B . 
N 5 HOH 270 870 9837  HOH HOH B . 
N 5 HOH 271 871 4374  HOH HOH B . 
N 5 HOH 272 872 2581  HOH HOH B . 
N 5 HOH 273 873 7010  HOH HOH B . 
N 5 HOH 274 874 743   HOH HOH B . 
N 5 HOH 275 875 603   HOH HOH B . 
N 5 HOH 276 876 4693  HOH HOH B . 
N 5 HOH 277 877 11303 HOH HOH B . 
N 5 HOH 278 878 944   HOH HOH B . 
N 5 HOH 279 879 1509  HOH HOH B . 
N 5 HOH 280 880 2042  HOH HOH B . 
N 5 HOH 281 881 1698  HOH HOH B . 
N 5 HOH 282 882 4888  HOH HOH B . 
N 5 HOH 283 883 2941  HOH HOH B . 
N 5 HOH 284 884 1852  HOH HOH B . 
N 5 HOH 285 885 626   HOH HOH B . 
N 5 HOH 286 886 4958  HOH HOH B . 
N 5 HOH 287 887 1533  HOH HOH B . 
N 5 HOH 288 888 10034 HOH HOH B . 
N 5 HOH 289 889 11005 HOH HOH B . 
N 5 HOH 290 890 667   HOH HOH B . 
N 5 HOH 291 891 760   HOH HOH B . 
N 5 HOH 292 892 6499  HOH HOH B . 
N 5 HOH 293 893 1     HOH HOH B . 
N 5 HOH 294 894 260   HOH HOH B . 
N 5 HOH 295 895 1163  HOH HOH B . 
N 5 HOH 296 896 4426  HOH HOH B . 
N 5 HOH 297 897 10379 HOH HOH B . 
N 5 HOH 298 898 790   HOH HOH B . 
N 5 HOH 299 899 4480  HOH HOH B . 
N 5 HOH 300 900 309   HOH HOH B . 
N 5 HOH 301 901 1745  HOH HOH B . 
N 5 HOH 302 902 9581  HOH HOH B . 
N 5 HOH 303 903 1735  HOH HOH B . 
N 5 HOH 304 904 812   HOH HOH B . 
N 5 HOH 305 905 1479  HOH HOH B . 
N 5 HOH 306 906 2266  HOH HOH B . 
N 5 HOH 307 907 7568  HOH HOH B . 
N 5 HOH 308 908 2376  HOH HOH B . 
N 5 HOH 309 909 185   HOH HOH B . 
N 5 HOH 310 910 1759  HOH HOH B . 
N 5 HOH 311 911 968   HOH HOH B . 
N 5 HOH 312 912 964   HOH HOH B . 
N 5 HOH 313 913 1290  HOH HOH B . 
N 5 HOH 314 914 8551  HOH HOH B . 
N 5 HOH 315 915 7785  HOH HOH B . 
N 5 HOH 316 916 833   HOH HOH B . 
N 5 HOH 317 917 5664  HOH HOH B . 
N 5 HOH 318 918 8499  HOH HOH B . 
N 5 HOH 319 919 800   HOH HOH B . 
N 5 HOH 320 920 10815 HOH HOH B . 
N 5 HOH 321 921 3137  HOH HOH B . 
N 5 HOH 322 922 4488  HOH HOH B . 
N 5 HOH 323 923 1418  HOH HOH B . 
N 5 HOH 324 924 136   HOH HOH B . 
N 5 HOH 325 925 853   HOH HOH B . 
N 5 HOH 326 926 1353  HOH HOH B . 
N 5 HOH 327 927 2613  HOH HOH B . 
N 5 HOH 328 928 7348  HOH HOH B . 
N 5 HOH 329 929 5633  HOH HOH B . 
N 5 HOH 330 930 8263  HOH HOH B . 
N 5 HOH 331 931 5331  HOH HOH B . 
N 5 HOH 332 932 6172  HOH HOH B . 
N 5 HOH 333 933 5979  HOH HOH B . 
N 5 HOH 334 934 5643  HOH HOH B . 
N 5 HOH 335 935 4934  HOH HOH B . 
N 5 HOH 336 936 6325  HOH HOH B . 
N 5 HOH 337 937 7997  HOH HOH B . 
N 5 HOH 338 938 8227  HOH HOH B . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.21.1_5286 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? xia2   ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? xia2   ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9GQT 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     92.089 
_cell.length_a_esd                 ? 
_cell.length_b                     92.089 
_cell.length_b_esd                 ? 
_cell.length_c                     146.804 
_cell.length_c_esd                 ? 
_cell.volume                       1244956.985 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9GQT 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                75 
_symmetry.space_group_name_Hall            'P 4' 
_symmetry.space_group_name_H-M             'P 4' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9GQT 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.80 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          56.02 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '25% w/v pentaerythritol ethoxylate 797, 100 mM MES pH 6.5, 50 mM magnesium chloride' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293.15 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 X CdTe 9M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-10-07 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.6199 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'DIAMOND BEAMLINE I24' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.6199 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   I24 
_diffrn_source.pdbx_synchrotron_site       Diamond 
# 
_reflns.B_iso_Wilson_estimate                          19.98 
_reflns.entry_id                                       9GQT 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.94 
_reflns.d_resolution_low                               41.18 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     90312 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.9 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                13.9 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          4.1 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.983 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.94 
_reflns_shell.d_res_low                                     1.97 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             4440 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.282 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               25.73 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9GQT 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.94 
_refine.ls_d_res_low                             39.12 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     89970 
_refine.ls_number_reflns_R_free                  1948 
_refine.ls_number_reflns_R_work                  88022 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.54 
_refine.ls_percent_reflns_R_free                 2.17 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1832 
_refine.ls_R_factor_R_free                       0.2122 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1826 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.33 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 25.2770 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2694 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.94 
_refine_hist.d_res_low                        39.12 
_refine_hist.number_atoms_solvent             695 
_refine_hist.number_atoms_total               7070 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        6273 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         102 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0128  ? 6543 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.1541  ? 8887 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0678  ? 955  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0095  ? 1150 ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 15.6360 ? 2439 ? f_dihedral_angle_d ? ? 
# 
_refine_ls_restr_ncs.pdbx_ordinal        1 
_refine_ls_restr_ncs.pdbx_refine_id      'X-RAY DIFFRACTION' 
_refine_ls_restr_ncs.dom_id              d_2 
_refine_ls_restr_ncs.pdbx_ens_id         ens_1 
_refine_ls_restr_ncs.rms_dev_position    0.466204415741 
_refine_ls_restr_ncs.weight_position     ? 
_refine_ls_restr_ncs.rms_dev_B_iso       ? 
_refine_ls_restr_ncs.weight_B_iso        ? 
_refine_ls_restr_ncs.pdbx_type           'Torsion NCS' 
_refine_ls_restr_ncs.pdbx_asym_id        A 
_refine_ls_restr_ncs.pdbx_auth_asym_id   A 
_refine_ls_restr_ncs.pdbx_number         ? 
_refine_ls_restr_ncs.pdbx_rms            ? 
_refine_ls_restr_ncs.pdbx_weight         ? 
_refine_ls_restr_ncs.ncs_model_details   ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.94 1.99  . . 114 6171 97.87  . . . . 0.3402 . . . . . . . . . . . 0.3413 
'X-RAY DIFFRACTION' 1.99 2.04  . . 148 6116 96.70  . . . . 0.3643 . . . . . . . . . . . 0.3915 
'X-RAY DIFFRACTION' 2.04 2.10  . . 125 6310 99.84  . . . . 0.2664 . . . . . . . . . . . 0.2966 
'X-RAY DIFFRACTION' 2.10 2.17  . . 162 6231 99.83  . . . . 0.2447 . . . . . . . . . . . 0.3017 
'X-RAY DIFFRACTION' 2.17 2.25  . . 144 6320 99.97  . . . . 0.2228 . . . . . . . . . . . 0.2701 
'X-RAY DIFFRACTION' 2.25 2.34  . . 129 6293 99.94  . . . . 0.2069 . . . . . . . . . . . 0.2810 
'X-RAY DIFFRACTION' 2.34 2.44  . . 147 6271 99.92  . . . . 0.2010 . . . . . . . . . . . 0.2576 
'X-RAY DIFFRACTION' 2.44 2.57  . . 145 6304 99.97  . . . . 0.1923 . . . . . . . . . . . 0.2304 
'X-RAY DIFFRACTION' 2.57 2.73  . . 134 6309 99.98  . . . . 0.1848 . . . . . . . . . . . 0.2409 
'X-RAY DIFFRACTION' 2.73 2.94  . . 102 6356 99.97  . . . . 0.1537 . . . . . . . . . . . 0.2042 
'X-RAY DIFFRACTION' 2.94 3.24  . . 149 6287 100.00 . . . . 0.1543 . . . . . . . . . . . 0.1724 
'X-RAY DIFFRACTION' 3.24 3.71  . . 141 6344 99.95  . . . . 0.1332 . . . . . . . . . . . 0.1501 
'X-RAY DIFFRACTION' 3.71 4.67  . . 155 6332 100.00 . . . . 0.1214 . . . . . . . . . . . 0.1484 
'X-RAY DIFFRACTION' 4.67 39.12 . . 153 6378 99.68  . . . . 0.1609 . . . . . . . . . . . 0.1705 
# 
_struct_ncs_oper.id             1 
_struct_ncs_oper.code           given 
_struct_ncs_oper.matrix[1][1]   -0.24237459611 
_struct_ncs_oper.matrix[1][2]   -0.970160420626 
_struct_ncs_oper.matrix[1][3]   0.00658129249009 
_struct_ncs_oper.matrix[2][1]   -0.970178660614 
_struct_ncs_oper.matrix[2][2]   0.242387678914 
_struct_ncs_oper.matrix[2][3]   0.00125682142208 
_struct_ncs_oper.matrix[3][1]   -0.00281454261042 
_struct_ncs_oper.matrix[3][2]   -0.00608040794858 
_struct_ncs_oper.matrix[3][3]   -0.999977553243 
_struct_ncs_oper.vector[1]      56.0578399674 
_struct_ncs_oper.vector[2]      33.5607218547 
_struct_ncs_oper.vector[3]      -104.731255751 
_struct_ncs_oper.details        ? 
# 
loop_
_struct_ncs_dom.pdbx_ens_id 
_struct_ncs_dom.id 
_struct_ncs_dom.details 
ens_1 d_1 
;(chain "A" and (resid 66 through 167 or resid 169 through 469 or resid 500 through 504))
;
ens_1 d_2 
;(chain "B" and (resid 66 through 167 or resid 169 through 469 or resid 500 through 504))
;
# 
loop_
_struct_ncs_dom_lim.pdbx_ens_id 
_struct_ncs_dom_lim.dom_id 
_struct_ncs_dom_lim.pdbx_component_id 
_struct_ncs_dom_lim.beg_label_asym_id 
_struct_ncs_dom_lim.beg_label_comp_id 
_struct_ncs_dom_lim.beg_label_seq_id 
_struct_ncs_dom_lim.beg_label_alt_id 
_struct_ncs_dom_lim.end_label_asym_id 
_struct_ncs_dom_lim.end_label_comp_id 
_struct_ncs_dom_lim.end_label_seq_id 
_struct_ncs_dom_lim.end_label_alt_id 
_struct_ncs_dom_lim.beg_auth_asym_id 
_struct_ncs_dom_lim.beg_auth_comp_id 
_struct_ncs_dom_lim.beg_auth_seq_id 
_struct_ncs_dom_lim.end_auth_asym_id 
_struct_ncs_dom_lim.end_auth_comp_id 
_struct_ncs_dom_lim.end_auth_seq_id 
_struct_ncs_dom_lim.pdbx_refine_code 
_struct_ncs_dom_lim.selection_details 
ens_1 d_1 1 A ILE 108 . A PRO 209 . A ILE 66  A PRO 167 ? ? 
ens_1 d_1 2 A PRO 211 . A LYS 511 . A PRO 169 A LYS 469 ? ? 
ens_1 d_1 3 D CA  .   . D CA  .   . A CA  500 A CA  500 ? ? 
ens_1 d_1 4 E CA  .   . E CA  .   . A CA  501 A CA  501 ? ? 
ens_1 d_1 5 F NAG .   . F NAG .   . A NAG 502 A NAG 502 ? ? 
ens_1 d_1 6 G NAG .   . G NAG .   . A NAG 503 A NAG 503 ? ? 
ens_1 d_1 7 C NAG .   . C NAG .   . C NAG 1   C NAG 1   ? ? 
ens_1 d_2 1 B ILE 108 . B PRO 209 . B ILE 66  B PRO 167 ? ? 
ens_1 d_2 2 B PRO 211 . B LYS 511 . B PRO 169 B LYS 469 ? ? 
ens_1 d_2 3 H CA  .   . H CA  .   . B CA  500 B CA  500 ? ? 
ens_1 d_2 4 I CA  .   . I CA  .   . B CA  501 B CA  501 ? ? 
ens_1 d_2 5 J NAG .   . J NAG .   . B NAG 502 B NAG 502 ? ? 
ens_1 d_2 6 K NAG .   . K NAG .   . B NAG 503 B NAG 503 ? ? 
ens_1 d_2 7 L NAG .   . L NAG .   . B NAG 504 B NAG 504 ? ? 
# 
_struct_ncs_ens.id        ens_1 
_struct_ncs_ens.details   ? 
# 
_struct_ncs_ens_gen.ens_id     ens_1 
_struct_ncs_ens_gen.dom_id_1   d_2 
_struct_ncs_ens_gen.dom_id_2   d_1 
_struct_ncs_ens_gen.oper_id    1 
# 
_struct.entry_id                     9GQT 
_struct.title                        'influenza neuraminidase hybrid N1/09' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9GQT 
_struct_keywords.text            'influenza neuraminidase hybrid expression, VIRAL PROTEIN' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 3 ? 
E N N 3 ? 
F N N 4 ? 
G N N 4 ? 
H N N 3 ? 
I N N 3 ? 
J N N 4 ? 
K N N 4 ? 
L N N 4 ? 
M N N 5 ? 
N N N 5 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    A0A024CWJ7_9INFA 
_struct_ref.pdbx_db_accession          A0A024CWJ7 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;SVTLAGNSSLCPISGWAIYSKDNGIRIGSKGDVFVIREPFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPYRTLMSC
PVGEAPSPYNSRFESVAWSASACHDGISWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTV
MTDGPSNGQASYKIFKIEKGKVVKSVELNAPNYHYEECSCYPDAGEIMCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGV
FGDNPRPNDGTGSCGPMSSNGAYGVKGFSFKYGNGVWIGRTKSTSSRSGFEMIWDPNGWTETDSSFSVKQDIVAITDWSG
YSGSFVQHPELTGLDCMRPCFWVELIRGRPKENTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTIDK
;
_struct_ref.pdbx_align_begin           82 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9GQT A 124 ? 511 ? A0A024CWJ7 82 ? 469 ? 82 469 
2 1 9GQT B 124 ? 511 ? A0A024CWJ7 82 ? 469 ? 82 469 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9GQT MET A 1   ? UNP A0A024CWJ7 ?   ?   'initiating methionine' -41 1   
1 9GQT ASN A 2   ? UNP A0A024CWJ7 ?   ?   'expression tag'        -40 2   
1 9GQT THR A 3   ? UNP A0A024CWJ7 ?   ?   'expression tag'        -39 3   
1 9GQT GLN A 4   ? UNP A0A024CWJ7 ?   ?   'expression tag'        -38 4   
1 9GQT ILE A 5   ? UNP A0A024CWJ7 ?   ?   'expression tag'        -37 5   
1 9GQT LEU A 6   ? UNP A0A024CWJ7 ?   ?   'expression tag'        -36 6   
1 9GQT VAL A 7   ? UNP A0A024CWJ7 ?   ?   'expression tag'        -35 7   
1 9GQT PHE A 8   ? UNP A0A024CWJ7 ?   ?   'expression tag'        -34 8   
1 9GQT ALA A 9   ? UNP A0A024CWJ7 ?   ?   'expression tag'        -33 9   
1 9GQT LEU A 10  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -32 10  
1 9GQT ILE A 11  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -31 11  
1 9GQT ALA A 12  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -30 12  
1 9GQT ILE A 13  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -29 13  
1 9GQT ILE A 14  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -28 14  
1 9GQT PRO A 15  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -27 15  
1 9GQT THR A 16  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -26 16  
1 9GQT ASN A 17  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -25 17  
1 9GQT ALA A 18  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -24 18  
1 9GQT ASP A 19  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -23 19  
1 9GQT LYS A 20  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -22 20  
1 9GQT ILE A 21  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -21 21  
1 9GQT SER A 22  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -20 22  
1 9GQT ALA A 23  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -19 23  
1 9GQT TRP A 24  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -18 24  
1 9GQT SER A 25  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -17 25  
1 9GQT HIS A 26  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -16 26  
1 9GQT PRO A 27  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -15 27  
1 9GQT GLN A 28  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -14 28  
1 9GQT PHE A 29  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -13 29  
1 9GQT GLU A 30  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -12 30  
1 9GQT LYS A 31  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -11 31  
1 9GQT GLY A 32  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -10 32  
1 9GQT GLY A 33  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -9  33  
1 9GQT GLY A 34  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -8  34  
1 9GQT GLY A 35  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -7  35  
1 9GQT SER A 36  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -6  36  
1 9GQT HIS A 37  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -5  37  
1 9GQT HIS A 38  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -4  38  
1 9GQT HIS A 39  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -3  39  
1 9GQT HIS A 40  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -2  40  
1 9GQT HIS A 41  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -1  41  
1 9GQT HIS A 42  ? UNP A0A024CWJ7 ?   ?   'expression tag'        0   42  
1 9GQT SER A 43  ? UNP A0A024CWJ7 ?   ?   'expression tag'        1   43  
1 9GQT SER A 44  ? UNP A0A024CWJ7 ?   ?   'expression tag'        2   44  
1 9GQT SER A 45  ? UNP A0A024CWJ7 ?   ?   'expression tag'        3   45  
1 9GQT GLY A 46  ? UNP A0A024CWJ7 ?   ?   'expression tag'        4   46  
1 9GQT SER A 47  ? UNP A0A024CWJ7 ?   ?   'expression tag'        5   47  
1 9GQT GLY A 48  ? UNP A0A024CWJ7 ?   ?   'expression tag'        6   48  
1 9GQT ALA A 49  ? UNP A0A024CWJ7 ?   ?   'expression tag'        7   49  
1 9GQT HIS A 50  ? UNP A0A024CWJ7 ?   ?   'expression tag'        8   50  
1 9GQT ILE A 51  ? UNP A0A024CWJ7 ?   ?   'expression tag'        9   51  
1 9GQT VAL A 52  ? UNP A0A024CWJ7 ?   ?   'expression tag'        10  52  
1 9GQT MET A 53  ? UNP A0A024CWJ7 ?   ?   'expression tag'        11  53  
1 9GQT VAL A 54  ? UNP A0A024CWJ7 ?   ?   'expression tag'        12  54  
1 9GQT ASP A 55  ? UNP A0A024CWJ7 ?   ?   'expression tag'        13  55  
1 9GQT ALA A 56  ? UNP A0A024CWJ7 ?   ?   'expression tag'        14  56  
1 9GQT TYR A 57  ? UNP A0A024CWJ7 ?   ?   'expression tag'        15  57  
1 9GQT LYS A 58  ? UNP A0A024CWJ7 ?   ?   'expression tag'        16  58  
1 9GQT PRO A 59  ? UNP A0A024CWJ7 ?   ?   'expression tag'        17  59  
1 9GQT THR A 60  ? UNP A0A024CWJ7 ?   ?   'expression tag'        18  60  
1 9GQT LYS A 61  ? UNP A0A024CWJ7 ?   ?   'expression tag'        19  61  
1 9GQT GLY A 62  ? UNP A0A024CWJ7 ?   ?   'expression tag'        20  62  
1 9GQT GLY A 63  ? UNP A0A024CWJ7 ?   ?   'expression tag'        21  63  
1 9GQT SER A 64  ? UNP A0A024CWJ7 ?   ?   'expression tag'        22  64  
1 9GQT GLY A 65  ? UNP A0A024CWJ7 ?   ?   'expression tag'        23  65  
1 9GQT GLY A 66  ? UNP A0A024CWJ7 ?   ?   'expression tag'        24  66  
1 9GQT GLY A 67  ? UNP A0A024CWJ7 ?   ?   'expression tag'        25  67  
1 9GQT GLY A 68  ? UNP A0A024CWJ7 ?   ?   'expression tag'        26  68  
1 9GQT SER A 69  ? UNP A0A024CWJ7 ?   ?   'expression tag'        27  69  
1 9GQT ILE A 70  ? UNP A0A024CWJ7 ?   ?   'expression tag'        28  70  
1 9GQT ILE A 71  ? UNP A0A024CWJ7 ?   ?   'expression tag'        29  71  
1 9GQT ASN A 72  ? UNP A0A024CWJ7 ?   ?   'expression tag'        30  72  
1 9GQT GLU A 73  ? UNP A0A024CWJ7 ?   ?   'expression tag'        31  73  
1 9GQT THR A 74  ? UNP A0A024CWJ7 ?   ?   'expression tag'        32  74  
1 9GQT ALA A 75  ? UNP A0A024CWJ7 ?   ?   'expression tag'        33  75  
1 9GQT ASP A 76  ? UNP A0A024CWJ7 ?   ?   'expression tag'        34  76  
1 9GQT ASP A 77  ? UNP A0A024CWJ7 ?   ?   'expression tag'        35  77  
1 9GQT ILE A 78  ? UNP A0A024CWJ7 ?   ?   'expression tag'        36  78  
1 9GQT VAL A 79  ? UNP A0A024CWJ7 ?   ?   'expression tag'        37  79  
1 9GQT TYR A 80  ? UNP A0A024CWJ7 ?   ?   'expression tag'        38  80  
1 9GQT ARG A 81  ? UNP A0A024CWJ7 ?   ?   'expression tag'        39  81  
1 9GQT LEU A 82  ? UNP A0A024CWJ7 ?   ?   'expression tag'        40  82  
1 9GQT THR A 83  ? UNP A0A024CWJ7 ?   ?   'expression tag'        41  83  
1 9GQT VAL A 84  ? UNP A0A024CWJ7 ?   ?   'expression tag'        42  84  
1 9GQT ILE A 85  ? UNP A0A024CWJ7 ?   ?   'expression tag'        43  85  
1 9GQT ILE A 86  ? UNP A0A024CWJ7 ?   ?   'expression tag'        44  86  
1 9GQT ASP A 87  ? UNP A0A024CWJ7 ?   ?   'expression tag'        45  87  
1 9GQT ASP A 88  ? UNP A0A024CWJ7 ?   ?   'expression tag'        46  88  
1 9GQT ARG A 89  ? UNP A0A024CWJ7 ?   ?   'expression tag'        47  89  
1 9GQT TYR A 90  ? UNP A0A024CWJ7 ?   ?   'expression tag'        48  90  
1 9GQT GLU A 91  ? UNP A0A024CWJ7 ?   ?   'expression tag'        49  91  
1 9GQT SER A 92  ? UNP A0A024CWJ7 ?   ?   'expression tag'        50  92  
1 9GQT LEU A 93  ? UNP A0A024CWJ7 ?   ?   'expression tag'        51  93  
1 9GQT LYS A 94  ? UNP A0A024CWJ7 ?   ?   'expression tag'        52  94  
1 9GQT ASN A 95  ? UNP A0A024CWJ7 ?   ?   'expression tag'        53  95  
1 9GQT LEU A 96  ? UNP A0A024CWJ7 ?   ?   'expression tag'        54  96  
1 9GQT ILE A 97  ? UNP A0A024CWJ7 ?   ?   'expression tag'        55  97  
1 9GQT THR A 98  ? UNP A0A024CWJ7 ?   ?   'expression tag'        56  98  
1 9GQT LEU A 99  ? UNP A0A024CWJ7 ?   ?   'expression tag'        57  99  
1 9GQT ARG A 100 ? UNP A0A024CWJ7 ?   ?   'expression tag'        58  100 
1 9GQT ALA A 101 ? UNP A0A024CWJ7 ?   ?   'expression tag'        59  101 
1 9GQT ASP A 102 ? UNP A0A024CWJ7 ?   ?   'expression tag'        60  102 
1 9GQT ARG A 103 ? UNP A0A024CWJ7 ?   ?   'expression tag'        61  103 
1 9GQT LEU A 104 ? UNP A0A024CWJ7 ?   ?   'expression tag'        62  104 
1 9GQT GLU A 105 ? UNP A0A024CWJ7 ?   ?   'expression tag'        63  105 
1 9GQT MET A 106 ? UNP A0A024CWJ7 ?   ?   'expression tag'        64  106 
1 9GQT ILE A 107 ? UNP A0A024CWJ7 ?   ?   'expression tag'        65  107 
1 9GQT ILE A 108 ? UNP A0A024CWJ7 ?   ?   'expression tag'        66  108 
1 9GQT ASN A 109 ? UNP A0A024CWJ7 ?   ?   'expression tag'        67  109 
1 9GQT ASP A 110 ? UNP A0A024CWJ7 ?   ?   'expression tag'        68  110 
1 9GQT ASN A 111 ? UNP A0A024CWJ7 ?   ?   'expression tag'        69  111 
1 9GQT VAL A 112 ? UNP A0A024CWJ7 ?   ?   'expression tag'        70  112 
1 9GQT SER A 113 ? UNP A0A024CWJ7 ?   ?   'expression tag'        71  113 
1 9GQT THR A 114 ? UNP A0A024CWJ7 ?   ?   'expression tag'        72  114 
1 9GQT ILE A 115 ? UNP A0A024CWJ7 ?   ?   'expression tag'        73  115 
1 9GQT LEU A 116 ? UNP A0A024CWJ7 ?   ?   'expression tag'        74  116 
1 9GQT ALA A 117 ? UNP A0A024CWJ7 ?   ?   'expression tag'        75  117 
1 9GQT GLY A 118 ? UNP A0A024CWJ7 ?   ?   'expression tag'        76  118 
1 9GQT GLY A 119 ? UNP A0A024CWJ7 ?   ?   'expression tag'        77  119 
1 9GQT SER A 120 ? UNP A0A024CWJ7 ?   ?   'expression tag'        78  120 
1 9GQT GLY A 121 ? UNP A0A024CWJ7 ?   ?   'expression tag'        79  121 
1 9GQT THR A 122 ? UNP A0A024CWJ7 ?   ?   'expression tag'        80  122 
1 9GQT GLY A 123 ? UNP A0A024CWJ7 ?   ?   'expression tag'        81  123 
1 9GQT ILE A 191 ? UNP A0A024CWJ7 VAL 149 conflict                149 124 
1 9GQT VAL A 248 ? UNP A0A024CWJ7 LEU 206 conflict                206 125 
1 9GQT MET A 311 ? UNP A0A024CWJ7 LEU 269 conflict                269 126 
1 9GQT ASP A 329 ? UNP A0A024CWJ7 GLU 287 conflict                287 127 
1 9GQT ILE A 363 ? UNP A0A024CWJ7 VAL 321 conflict                321 128 
1 9GQT LYS A 373 ? UNP A0A024CWJ7 GLY 331 conflict                331 129 
1 9GQT VAL A 380 ? UNP A0A024CWJ7 MET 338 conflict                338 130 
1 9GQT ASN A 386 ? UNP A0A024CWJ7 TYR 344 conflict                344 131 
1 9GQT ILE A 407 ? UNP A0A024CWJ7 THR 365 conflict                365 132 
1 9GQT ASN A 411 ? UNP A0A024CWJ7 SER 369 conflict                369 133 
1 9GQT GLY A 437 ? UNP A0A024CWJ7 ALA 395 conflict                395 134 
1 9GQT ASN A 439 ? UNP A0A024CWJ7 THR 397 conflict                397 135 
1 9GQT GLU A 440 ? UNP A0A024CWJ7 ASP 398 conflict                398 136 
1 9GQT MET A 454 ? UNP A0A024CWJ7 LEU 412 conflict                412 137 
2 9GQT MET B 1   ? UNP A0A024CWJ7 ?   ?   'initiating methionine' -41 138 
2 9GQT ASN B 2   ? UNP A0A024CWJ7 ?   ?   'expression tag'        -40 139 
2 9GQT THR B 3   ? UNP A0A024CWJ7 ?   ?   'expression tag'        -39 140 
2 9GQT GLN B 4   ? UNP A0A024CWJ7 ?   ?   'expression tag'        -38 141 
2 9GQT ILE B 5   ? UNP A0A024CWJ7 ?   ?   'expression tag'        -37 142 
2 9GQT LEU B 6   ? UNP A0A024CWJ7 ?   ?   'expression tag'        -36 143 
2 9GQT VAL B 7   ? UNP A0A024CWJ7 ?   ?   'expression tag'        -35 144 
2 9GQT PHE B 8   ? UNP A0A024CWJ7 ?   ?   'expression tag'        -34 145 
2 9GQT ALA B 9   ? UNP A0A024CWJ7 ?   ?   'expression tag'        -33 146 
2 9GQT LEU B 10  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -32 147 
2 9GQT ILE B 11  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -31 148 
2 9GQT ALA B 12  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -30 149 
2 9GQT ILE B 13  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -29 150 
2 9GQT ILE B 14  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -28 151 
2 9GQT PRO B 15  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -27 152 
2 9GQT THR B 16  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -26 153 
2 9GQT ASN B 17  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -25 154 
2 9GQT ALA B 18  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -24 155 
2 9GQT ASP B 19  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -23 156 
2 9GQT LYS B 20  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -22 157 
2 9GQT ILE B 21  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -21 158 
2 9GQT SER B 22  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -20 159 
2 9GQT ALA B 23  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -19 160 
2 9GQT TRP B 24  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -18 161 
2 9GQT SER B 25  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -17 162 
2 9GQT HIS B 26  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -16 163 
2 9GQT PRO B 27  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -15 164 
2 9GQT GLN B 28  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -14 165 
2 9GQT PHE B 29  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -13 166 
2 9GQT GLU B 30  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -12 167 
2 9GQT LYS B 31  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -11 168 
2 9GQT GLY B 32  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -10 169 
2 9GQT GLY B 33  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -9  170 
2 9GQT GLY B 34  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -8  171 
2 9GQT GLY B 35  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -7  172 
2 9GQT SER B 36  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -6  173 
2 9GQT HIS B 37  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -5  174 
2 9GQT HIS B 38  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -4  175 
2 9GQT HIS B 39  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -3  176 
2 9GQT HIS B 40  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -2  177 
2 9GQT HIS B 41  ? UNP A0A024CWJ7 ?   ?   'expression tag'        -1  178 
2 9GQT HIS B 42  ? UNP A0A024CWJ7 ?   ?   'expression tag'        0   179 
2 9GQT SER B 43  ? UNP A0A024CWJ7 ?   ?   'expression tag'        1   180 
2 9GQT SER B 44  ? UNP A0A024CWJ7 ?   ?   'expression tag'        2   181 
2 9GQT SER B 45  ? UNP A0A024CWJ7 ?   ?   'expression tag'        3   182 
2 9GQT GLY B 46  ? UNP A0A024CWJ7 ?   ?   'expression tag'        4   183 
2 9GQT SER B 47  ? UNP A0A024CWJ7 ?   ?   'expression tag'        5   184 
2 9GQT GLY B 48  ? UNP A0A024CWJ7 ?   ?   'expression tag'        6   185 
2 9GQT ALA B 49  ? UNP A0A024CWJ7 ?   ?   'expression tag'        7   186 
2 9GQT HIS B 50  ? UNP A0A024CWJ7 ?   ?   'expression tag'        8   187 
2 9GQT ILE B 51  ? UNP A0A024CWJ7 ?   ?   'expression tag'        9   188 
2 9GQT VAL B 52  ? UNP A0A024CWJ7 ?   ?   'expression tag'        10  189 
2 9GQT MET B 53  ? UNP A0A024CWJ7 ?   ?   'expression tag'        11  190 
2 9GQT VAL B 54  ? UNP A0A024CWJ7 ?   ?   'expression tag'        12  191 
2 9GQT ASP B 55  ? UNP A0A024CWJ7 ?   ?   'expression tag'        13  192 
2 9GQT ALA B 56  ? UNP A0A024CWJ7 ?   ?   'expression tag'        14  193 
2 9GQT TYR B 57  ? UNP A0A024CWJ7 ?   ?   'expression tag'        15  194 
2 9GQT LYS B 58  ? UNP A0A024CWJ7 ?   ?   'expression tag'        16  195 
2 9GQT PRO B 59  ? UNP A0A024CWJ7 ?   ?   'expression tag'        17  196 
2 9GQT THR B 60  ? UNP A0A024CWJ7 ?   ?   'expression tag'        18  197 
2 9GQT LYS B 61  ? UNP A0A024CWJ7 ?   ?   'expression tag'        19  198 
2 9GQT GLY B 62  ? UNP A0A024CWJ7 ?   ?   'expression tag'        20  199 
2 9GQT GLY B 63  ? UNP A0A024CWJ7 ?   ?   'expression tag'        21  200 
2 9GQT SER B 64  ? UNP A0A024CWJ7 ?   ?   'expression tag'        22  201 
2 9GQT GLY B 65  ? UNP A0A024CWJ7 ?   ?   'expression tag'        23  202 
2 9GQT GLY B 66  ? UNP A0A024CWJ7 ?   ?   'expression tag'        24  203 
2 9GQT GLY B 67  ? UNP A0A024CWJ7 ?   ?   'expression tag'        25  204 
2 9GQT GLY B 68  ? UNP A0A024CWJ7 ?   ?   'expression tag'        26  205 
2 9GQT SER B 69  ? UNP A0A024CWJ7 ?   ?   'expression tag'        27  206 
2 9GQT ILE B 70  ? UNP A0A024CWJ7 ?   ?   'expression tag'        28  207 
2 9GQT ILE B 71  ? UNP A0A024CWJ7 ?   ?   'expression tag'        29  208 
2 9GQT ASN B 72  ? UNP A0A024CWJ7 ?   ?   'expression tag'        30  209 
2 9GQT GLU B 73  ? UNP A0A024CWJ7 ?   ?   'expression tag'        31  210 
2 9GQT THR B 74  ? UNP A0A024CWJ7 ?   ?   'expression tag'        32  211 
2 9GQT ALA B 75  ? UNP A0A024CWJ7 ?   ?   'expression tag'        33  212 
2 9GQT ASP B 76  ? UNP A0A024CWJ7 ?   ?   'expression tag'        34  213 
2 9GQT ASP B 77  ? UNP A0A024CWJ7 ?   ?   'expression tag'        35  214 
2 9GQT ILE B 78  ? UNP A0A024CWJ7 ?   ?   'expression tag'        36  215 
2 9GQT VAL B 79  ? UNP A0A024CWJ7 ?   ?   'expression tag'        37  216 
2 9GQT TYR B 80  ? UNP A0A024CWJ7 ?   ?   'expression tag'        38  217 
2 9GQT ARG B 81  ? UNP A0A024CWJ7 ?   ?   'expression tag'        39  218 
2 9GQT LEU B 82  ? UNP A0A024CWJ7 ?   ?   'expression tag'        40  219 
2 9GQT THR B 83  ? UNP A0A024CWJ7 ?   ?   'expression tag'        41  220 
2 9GQT VAL B 84  ? UNP A0A024CWJ7 ?   ?   'expression tag'        42  221 
2 9GQT ILE B 85  ? UNP A0A024CWJ7 ?   ?   'expression tag'        43  222 
2 9GQT ILE B 86  ? UNP A0A024CWJ7 ?   ?   'expression tag'        44  223 
2 9GQT ASP B 87  ? UNP A0A024CWJ7 ?   ?   'expression tag'        45  224 
2 9GQT ASP B 88  ? UNP A0A024CWJ7 ?   ?   'expression tag'        46  225 
2 9GQT ARG B 89  ? UNP A0A024CWJ7 ?   ?   'expression tag'        47  226 
2 9GQT TYR B 90  ? UNP A0A024CWJ7 ?   ?   'expression tag'        48  227 
2 9GQT GLU B 91  ? UNP A0A024CWJ7 ?   ?   'expression tag'        49  228 
2 9GQT SER B 92  ? UNP A0A024CWJ7 ?   ?   'expression tag'        50  229 
2 9GQT LEU B 93  ? UNP A0A024CWJ7 ?   ?   'expression tag'        51  230 
2 9GQT LYS B 94  ? UNP A0A024CWJ7 ?   ?   'expression tag'        52  231 
2 9GQT ASN B 95  ? UNP A0A024CWJ7 ?   ?   'expression tag'        53  232 
2 9GQT LEU B 96  ? UNP A0A024CWJ7 ?   ?   'expression tag'        54  233 
2 9GQT ILE B 97  ? UNP A0A024CWJ7 ?   ?   'expression tag'        55  234 
2 9GQT THR B 98  ? UNP A0A024CWJ7 ?   ?   'expression tag'        56  235 
2 9GQT LEU B 99  ? UNP A0A024CWJ7 ?   ?   'expression tag'        57  236 
2 9GQT ARG B 100 ? UNP A0A024CWJ7 ?   ?   'expression tag'        58  237 
2 9GQT ALA B 101 ? UNP A0A024CWJ7 ?   ?   'expression tag'        59  238 
2 9GQT ASP B 102 ? UNP A0A024CWJ7 ?   ?   'expression tag'        60  239 
2 9GQT ARG B 103 ? UNP A0A024CWJ7 ?   ?   'expression tag'        61  240 
2 9GQT LEU B 104 ? UNP A0A024CWJ7 ?   ?   'expression tag'        62  241 
2 9GQT GLU B 105 ? UNP A0A024CWJ7 ?   ?   'expression tag'        63  242 
2 9GQT MET B 106 ? UNP A0A024CWJ7 ?   ?   'expression tag'        64  243 
2 9GQT ILE B 107 ? UNP A0A024CWJ7 ?   ?   'expression tag'        65  244 
2 9GQT ILE B 108 ? UNP A0A024CWJ7 ?   ?   'expression tag'        66  245 
2 9GQT ASN B 109 ? UNP A0A024CWJ7 ?   ?   'expression tag'        67  246 
2 9GQT ASP B 110 ? UNP A0A024CWJ7 ?   ?   'expression tag'        68  247 
2 9GQT ASN B 111 ? UNP A0A024CWJ7 ?   ?   'expression tag'        69  248 
2 9GQT VAL B 112 ? UNP A0A024CWJ7 ?   ?   'expression tag'        70  249 
2 9GQT SER B 113 ? UNP A0A024CWJ7 ?   ?   'expression tag'        71  250 
2 9GQT THR B 114 ? UNP A0A024CWJ7 ?   ?   'expression tag'        72  251 
2 9GQT ILE B 115 ? UNP A0A024CWJ7 ?   ?   'expression tag'        73  252 
2 9GQT LEU B 116 ? UNP A0A024CWJ7 ?   ?   'expression tag'        74  253 
2 9GQT ALA B 117 ? UNP A0A024CWJ7 ?   ?   'expression tag'        75  254 
2 9GQT GLY B 118 ? UNP A0A024CWJ7 ?   ?   'expression tag'        76  255 
2 9GQT GLY B 119 ? UNP A0A024CWJ7 ?   ?   'expression tag'        77  256 
2 9GQT SER B 120 ? UNP A0A024CWJ7 ?   ?   'expression tag'        78  257 
2 9GQT GLY B 121 ? UNP A0A024CWJ7 ?   ?   'expression tag'        79  258 
2 9GQT THR B 122 ? UNP A0A024CWJ7 ?   ?   'expression tag'        80  259 
2 9GQT GLY B 123 ? UNP A0A024CWJ7 ?   ?   'expression tag'        81  260 
2 9GQT ILE B 191 ? UNP A0A024CWJ7 VAL 149 conflict                149 261 
2 9GQT VAL B 248 ? UNP A0A024CWJ7 LEU 206 conflict                206 262 
2 9GQT MET B 311 ? UNP A0A024CWJ7 LEU 269 conflict                269 263 
2 9GQT ASP B 329 ? UNP A0A024CWJ7 GLU 287 conflict                287 264 
2 9GQT ILE B 363 ? UNP A0A024CWJ7 VAL 321 conflict                321 265 
2 9GQT LYS B 373 ? UNP A0A024CWJ7 GLY 331 conflict                331 266 
2 9GQT VAL B 380 ? UNP A0A024CWJ7 MET 338 conflict                338 267 
2 9GQT ASN B 386 ? UNP A0A024CWJ7 TYR 344 conflict                344 268 
2 9GQT ILE B 407 ? UNP A0A024CWJ7 THR 365 conflict                365 269 
2 9GQT ASN B 411 ? UNP A0A024CWJ7 SER 369 conflict                369 270 
2 9GQT GLY B 437 ? UNP A0A024CWJ7 ALA 395 conflict                395 271 
2 9GQT ASN B 439 ? UNP A0A024CWJ7 THR 397 conflict                397 272 
2 9GQT GLU B 440 ? UNP A0A024CWJ7 ASP 398 conflict                398 273 
2 9GQT MET B 454 ? UNP A0A024CWJ7 LEU 412 conflict                412 274 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 author_defined_assembly ? tetrameric 4 
2 author_defined_assembly ? tetrameric 4 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 21360 ? 
1 MORE         -145  ? 
1 'SSA (A^2)'  50310 ? 
2 'ABSA (A^2)' 18150 ? 
2 MORE         -149  ? 
2 'SSA (A^2)'  47320 ? 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1,2,4,6 A,C,D,E,F,G,M 
2 1,3,5,7 B,H,I,J,K,L,N 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z       1.0000000000  0.0000000000  0.0000000000 0.0000000000  0.0000000000  1.0000000000 
0.0000000000 0.0000000000  0.0000000000 0.0000000000 1.0000000000 0.0000000000 
2 'crystal symmetry operation' 2_665 -x+1,-y+1,z -1.0000000000 0.0000000000  0.0000000000 92.0890000000 0.0000000000  
-1.0000000000 0.0000000000 92.0890000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 
3 'crystal symmetry operation' 2_555 -x,-y,z     -1.0000000000 0.0000000000  0.0000000000 0.0000000000  0.0000000000  
-1.0000000000 0.0000000000 0.0000000000  0.0000000000 0.0000000000 1.0000000000 0.0000000000 
4 'crystal symmetry operation' 3_655 -y+1,x,z    0.0000000000  -1.0000000000 0.0000000000 92.0890000000 1.0000000000  0.0000000000 
0.0000000000 0.0000000000  0.0000000000 0.0000000000 1.0000000000 0.0000000000 
5 'crystal symmetry operation' 3_555 -y,x,z      0.0000000000  -1.0000000000 0.0000000000 0.0000000000  1.0000000000  0.0000000000 
0.0000000000 0.0000000000  0.0000000000 0.0000000000 1.0000000000 0.0000000000 
6 'crystal symmetry operation' 4_565 y,-x+1,z    0.0000000000  1.0000000000  0.0000000000 0.0000000000  -1.0000000000 0.0000000000 
0.0000000000 92.0890000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 
7 'crystal symmetry operation' 4_555 y,-x,z      0.0000000000  1.0000000000  0.0000000000 0.0000000000  -1.0000000000 0.0000000000 
0.0000000000 0.0000000000  0.0000000000 0.0000000000 1.0000000000 0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ILE A 97  ? SER A 120 ? ILE A 55  SER A 78  1 ? 24 
HELX_P HELX_P2  AA2 ASN A 146 ? SER A 152 ? ASN A 104 SER A 110 1 ? 7  
HELX_P HELX_P3  AA3 ASP A 184 ? ASN A 188 ? ASP A 142 ASN A 146 5 ? 5  
HELX_P HELX_P4  AA4 HIS A 451 ? GLY A 456 ? HIS A 409 GLY A 414 1 ? 6  
HELX_P HELX_P5  AA5 PHE A 507 ? LYS A 511 ? PHE A 465 LYS A 469 5 ? 5  
HELX_P HELX_P6  AA6 ASN B 109 ? GLY B 121 ? ASN B 67  GLY B 79  1 ? 13 
HELX_P HELX_P7  AA7 ASN B 146 ? SER B 152 ? ASN B 104 SER B 110 1 ? 7  
HELX_P HELX_P8  AA8 ASP B 184 ? ASN B 188 ? ASP B 142 ASN B 146 5 ? 5  
HELX_P HELX_P9  AA9 HIS B 451 ? GLY B 456 ? HIS B 409 GLY B 414 1 ? 6  
HELX_P HELX_P10 AB1 PHE B 507 ? LYS B 511 ? PHE B 465 LYS B 469 5 ? 5  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1  disulf ?    ? A CYS 134 SG  ? ? ? 1_555 A CYS 459 SG ? ? A CYS 92  A CYS 417 1_555 ? ? ? ? ? ? ? 2.064 ? ?               
disulf2  disulf ?    ? A CYS 166 SG  ? ? ? 1_555 A CYS 171 SG ? ? A CYS 124 A CYS 129 1_555 ? ? ? ? ? ? ? 2.116 ? ?               
disulf3  disulf ?    ? A CYS 226 SG  ? ? ? 1_555 A CYS 273 SG ? ? A CYS 184 A CYS 231 1_555 ? ? ? ? ? ? ? 2.007 ? ?               
disulf4  disulf ?    ? A CYS 275 SG  ? ? ? 1_555 A CYS 280 SG ? ? A CYS 233 A CYS 238 1_555 ? ? ? ? ? ? ? 2.110 ? ?               
disulf5  disulf ?    ? A CYS 321 SG  ? ? ? 1_555 A CYS 334 SG ? ? A CYS 279 A CYS 292 1_555 ? ? ? ? ? ? ? 2.123 ? ?               
disulf6  disulf ?    ? A CYS 323 SG  ? ? ? 1_555 A CYS 332 SG ? ? A CYS 281 A CYS 290 1_555 ? ? ? ? ? ? ? 2.072 ? ?               
disulf7  disulf ?    ? A CYS 360 SG  ? ? ? 1_555 A CYS 377 SG ? ? A CYS 318 A CYS 335 1_555 ? ? ? ? ? ? ? 2.102 ? ?               
disulf8  disulf ?    ? A CYS 463 SG  ? ? ? 1_555 A CYS 488 SG ? ? A CYS 421 A CYS 446 1_555 ? ? ? ? ? ? ? 2.137 ? ?               
disulf9  disulf ?    ? B CYS 134 SG  ? ? ? 1_555 B CYS 459 SG ? ? B CYS 92  B CYS 417 1_555 ? ? ? ? ? ? ? 2.052 ? ?               
disulf10 disulf ?    ? B CYS 166 SG  ? ? ? 1_555 B CYS 171 SG ? ? B CYS 124 B CYS 129 1_555 ? ? ? ? ? ? ? 2.084 ? ?               
disulf11 disulf ?    ? B CYS 226 SG  ? ? ? 1_555 B CYS 273 SG ? ? B CYS 184 B CYS 231 1_555 ? ? ? ? ? ? ? 2.051 ? ?               
disulf12 disulf ?    ? B CYS 275 SG  ? ? ? 1_555 B CYS 280 SG ? ? B CYS 233 B CYS 238 1_555 ? ? ? ? ? ? ? 2.087 ? ?               
disulf13 disulf ?    ? B CYS 321 SG  ? ? ? 1_555 B CYS 334 SG ? ? B CYS 279 B CYS 292 1_555 ? ? ? ? ? ? ? 2.113 ? ?               
disulf14 disulf ?    ? B CYS 323 SG  ? ? ? 1_555 B CYS 332 SG ? ? B CYS 281 B CYS 290 1_555 ? ? ? ? ? ? ? 2.052 ? ?               
disulf15 disulf ?    ? B CYS 360 SG  ? ? ? 1_555 B CYS 377 SG ? ? B CYS 318 B CYS 335 1_555 ? ? ? ? ? ? ? 2.062 ? ?               
disulf16 disulf ?    ? B CYS 463 SG  ? ? ? 1_555 B CYS 488 SG ? ? B CYS 421 B CYS 446 1_555 ? ? ? ? ? ? ? 2.124 ? ?               
covale1  covale one  ? A ASN 111 ND2 ? ? ? 1_555 F NAG .   C1 ? ? A ASN 69  A NAG 502 1_555 ? ? ? ? ? ? ? 1.457 ? N-Glycosylation 
covale2  covale one  ? A ASN 130 ND2 ? ? ? 1_555 G NAG .   C1 ? ? A ASN 88  A NAG 503 1_555 ? ? ? ? ? ? ? 1.451 ? N-Glycosylation 
covale3  covale one  ? A ASN 188 ND2 ? ? ? 1_555 C NAG .   C1 ? ? A ASN 146 C NAG 1   1_555 ? ? ? ? ? ? ? 1.431 ? N-Glycosylation 
covale4  covale one  ? B ASN 111 ND2 ? ? ? 1_555 J NAG .   C1 ? ? B ASN 69  B NAG 502 1_555 ? ? ? ? ? ? ? 1.455 ? N-Glycosylation 
covale5  covale one  ? B ASN 130 ND2 ? ? ? 1_555 K NAG .   C1 ? ? B ASN 88  B NAG 503 1_555 ? ? ? ? ? ? ? 1.459 ? N-Glycosylation 
covale6  covale one  ? B ASN 188 ND2 ? ? ? 1_555 L NAG .   C1 ? ? B ASN 146 B NAG 504 1_555 ? ? ? ? ? ? ? 1.461 ? N-Glycosylation 
covale7  covale both ? C NAG .   O4  ? ? ? 1_555 C NAG .   C1 ? ? C NAG 1   C NAG 2   1_555 ? ? ? ? ? ? ? 1.464 ? ?               
metalc1  metalc ?    ? A ASP 336 O   ? ? ? 1_555 E CA  .   CA ? ? A ASP 294 A CA  501 1_555 ? ? ? ? ? ? ? 2.338 ? ?               
metalc2  metalc ?    ? A GLY 340 O   ? ? ? 1_555 E CA  .   CA ? ? A GLY 298 A CA  501 1_555 ? ? ? ? ? ? ? 2.356 ? ?               
metalc3  metalc ?    ? A ASP 366 OD2 ? ? ? 1_555 E CA  .   CA ? ? A ASP 324 A CA  501 1_555 ? ? ? ? ? ? ? 2.428 ? ?               
metalc4  metalc ?    ? A GLY 384 O   ? ? ? 1_555 E CA  .   CA ? ? A GLY 342 A CA  501 1_555 ? ? ? ? ? ? ? 2.397 ? ?               
metalc5  metalc ?    ? A ASN 386 O   ? ? ? 1_555 E CA  .   CA ? ? A ASN 344 A CA  501 1_555 ? ? ? ? ? ? ? 2.360 ? ?               
metalc6  metalc ?    ? A ASP 418 OD1 ? ? ? 1_555 D CA  .   CA ? ? A ASP 376 A CA  500 1_555 ? ? ? ? ? ? ? 2.308 ? ?               
metalc7  metalc ?    ? A ASP 418 OD2 ? ? ? 1_555 D CA  .   CA ? ? A ASP 376 A CA  500 1_555 ? ? ? ? ? ? ? 3.021 ? ?               
metalc8  metalc ?    ? A ASN 420 OD1 ? ? ? 1_555 D CA  .   CA ? ? A ASN 378 A CA  500 1_555 ? ? ? ? ? ? ? 2.311 ? ?               
metalc9  metalc ?    ? A ASP 426 OD1 ? ? ? 1_555 D CA  .   CA ? ? A ASP 384 A CA  500 1_555 ? ? ? ? ? ? ? 2.378 ? ?               
metalc10 metalc ?    ? A SER 428 O   ? ? ? 1_555 D CA  .   CA ? ? A SER 386 A CA  500 1_555 ? ? ? ? ? ? ? 2.286 ? ?               
metalc11 metalc ?    ? B ASP 336 O   ? ? ? 1_555 I CA  .   CA ? ? B ASP 294 B CA  501 1_555 ? ? ? ? ? ? ? 2.372 ? ?               
metalc12 metalc ?    ? B GLY 340 O   ? ? ? 1_555 I CA  .   CA ? ? B GLY 298 B CA  501 1_555 ? ? ? ? ? ? ? 2.459 ? ?               
metalc13 metalc ?    ? B ASP 366 OD2 ? ? ? 1_555 I CA  .   CA ? ? B ASP 324 B CA  501 1_555 ? ? ? ? ? ? ? 2.418 ? ?               
metalc14 metalc ?    ? B GLY 384 O   ? ? ? 1_555 I CA  .   CA ? ? B GLY 342 B CA  501 1_555 ? ? ? ? ? ? ? 2.533 ? ?               
metalc15 metalc ?    ? B ASN 386 O   ? ? ? 1_555 I CA  .   CA ? ? B ASN 344 B CA  501 1_555 ? ? ? ? ? ? ? 2.344 ? ?               
metalc16 metalc ?    ? B ASP 418 OD1 ? ? ? 1_555 H CA  .   CA ? ? B ASP 376 B CA  500 1_555 ? ? ? ? ? ? ? 2.370 ? ?               
metalc17 metalc ?    ? B ASP 418 OD2 ? ? ? 1_555 H CA  .   CA ? ? B ASP 376 B CA  500 1_555 ? ? ? ? ? ? ? 2.952 ? ?               
metalc18 metalc ?    ? B ASN 420 OD1 ? ? ? 1_555 H CA  .   CA ? ? B ASN 378 B CA  500 1_555 ? ? ? ? ? ? ? 2.320 ? ?               
metalc19 metalc ?    ? B ASP 426 OD1 ? ? ? 1_555 H CA  .   CA ? ? B ASP 384 B CA  500 1_555 ? ? ? ? ? ? ? 2.487 ? ?               
metalc20 metalc ?    ? B SER 428 O   ? ? ? 1_555 H CA  .   CA ? ? B SER 386 B CA  500 1_555 ? ? ? ? ? ? ? 2.254 ? ?               
metalc21 metalc ?    ? I CA  .   CA  ? ? ? 1_555 N HOH .   O  ? ? B CA  501 B HOH 660 1_555 ? ? ? ? ? ? ? 2.488 ? ?               
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
covale ? ? 
metalc ? ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  O   ? A ASP 336 ? A ASP 294 ? 1_555 CA ? E CA . ? A CA 501 ? 1_555 O   ? A GLY 340 ? A GLY 298 ? 1_555 88.6  ? 
2  O   ? A ASP 336 ? A ASP 294 ? 1_555 CA ? E CA . ? A CA 501 ? 1_555 OD2 ? A ASP 366 ? A ASP 324 ? 1_555 94.3  ? 
3  O   ? A GLY 340 ? A GLY 298 ? 1_555 CA ? E CA . ? A CA 501 ? 1_555 OD2 ? A ASP 366 ? A ASP 324 ? 1_555 86.8  ? 
4  O   ? A ASP 336 ? A ASP 294 ? 1_555 CA ? E CA . ? A CA 501 ? 1_555 O   ? A GLY 384 ? A GLY 342 ? 1_555 91.6  ? 
5  O   ? A GLY 340 ? A GLY 298 ? 1_555 CA ? E CA . ? A CA 501 ? 1_555 O   ? A GLY 384 ? A GLY 342 ? 1_555 78.9  ? 
6  OD2 ? A ASP 366 ? A ASP 324 ? 1_555 CA ? E CA . ? A CA 501 ? 1_555 O   ? A GLY 384 ? A GLY 342 ? 1_555 164.4 ? 
7  O   ? A ASP 336 ? A ASP 294 ? 1_555 CA ? E CA . ? A CA 501 ? 1_555 O   ? A ASN 386 ? A ASN 344 ? 1_555 86.1  ? 
8  O   ? A GLY 340 ? A GLY 298 ? 1_555 CA ? E CA . ? A CA 501 ? 1_555 O   ? A ASN 386 ? A ASN 344 ? 1_555 167.5 ? 
9  OD2 ? A ASP 366 ? A ASP 324 ? 1_555 CA ? E CA . ? A CA 501 ? 1_555 O   ? A ASN 386 ? A ASN 344 ? 1_555 104.9 ? 
10 O   ? A GLY 384 ? A GLY 342 ? 1_555 CA ? E CA . ? A CA 501 ? 1_555 O   ? A ASN 386 ? A ASN 344 ? 1_555 89.9  ? 
11 OD1 ? A ASP 418 ? A ASP 376 ? 1_555 CA ? D CA . ? A CA 500 ? 1_555 OD2 ? A ASP 418 ? A ASP 376 ? 1_555 46.7  ? 
12 OD1 ? A ASP 418 ? A ASP 376 ? 1_555 CA ? D CA . ? A CA 500 ? 1_555 OD1 ? A ASN 420 ? A ASN 378 ? 1_555 78.0  ? 
13 OD2 ? A ASP 418 ? A ASP 376 ? 1_555 CA ? D CA . ? A CA 500 ? 1_555 OD1 ? A ASN 420 ? A ASN 378 ? 1_555 105.5 ? 
14 OD1 ? A ASP 418 ? A ASP 376 ? 1_555 CA ? D CA . ? A CA 500 ? 1_555 OD1 ? A ASP 426 ? A ASP 384 ? 1_555 165.8 ? 
15 OD2 ? A ASP 418 ? A ASP 376 ? 1_555 CA ? D CA . ? A CA 500 ? 1_555 OD1 ? A ASP 426 ? A ASP 384 ? 1_555 121.3 ? 
16 OD1 ? A ASN 420 ? A ASN 378 ? 1_555 CA ? D CA . ? A CA 500 ? 1_555 OD1 ? A ASP 426 ? A ASP 384 ? 1_555 115.4 ? 
17 OD1 ? A ASP 418 ? A ASP 376 ? 1_555 CA ? D CA . ? A CA 500 ? 1_555 O   ? A SER 428 ? A SER 386 ? 1_555 88.1  ? 
18 OD2 ? A ASP 418 ? A ASP 376 ? 1_555 CA ? D CA . ? A CA 500 ? 1_555 O   ? A SER 428 ? A SER 386 ? 1_555 82.7  ? 
19 OD1 ? A ASN 420 ? A ASN 378 ? 1_555 CA ? D CA . ? A CA 500 ? 1_555 O   ? A SER 428 ? A SER 386 ? 1_555 149.9 ? 
20 OD1 ? A ASP 426 ? A ASP 384 ? 1_555 CA ? D CA . ? A CA 500 ? 1_555 O   ? A SER 428 ? A SER 386 ? 1_555 82.0  ? 
21 O   ? B ASP 336 ? B ASP 294 ? 1_555 CA ? I CA . ? B CA 501 ? 1_555 O   ? B GLY 340 ? B GLY 298 ? 1_555 85.6  ? 
22 O   ? B ASP 336 ? B ASP 294 ? 1_555 CA ? I CA . ? B CA 501 ? 1_555 OD2 ? B ASP 366 ? B ASP 324 ? 1_555 92.3  ? 
23 O   ? B GLY 340 ? B GLY 298 ? 1_555 CA ? I CA . ? B CA 501 ? 1_555 OD2 ? B ASP 366 ? B ASP 324 ? 1_555 84.0  ? 
24 O   ? B ASP 336 ? B ASP 294 ? 1_555 CA ? I CA . ? B CA 501 ? 1_555 O   ? B GLY 384 ? B GLY 342 ? 1_555 93.7  ? 
25 O   ? B GLY 340 ? B GLY 298 ? 1_555 CA ? I CA . ? B CA 501 ? 1_555 O   ? B GLY 384 ? B GLY 342 ? 1_555 83.8  ? 
26 OD2 ? B ASP 366 ? B ASP 324 ? 1_555 CA ? I CA . ? B CA 501 ? 1_555 O   ? B GLY 384 ? B GLY 342 ? 1_555 165.9 ? 
27 O   ? B ASP 336 ? B ASP 294 ? 1_555 CA ? I CA . ? B CA 501 ? 1_555 O   ? B ASN 386 ? B ASN 344 ? 1_555 91.5  ? 
28 O   ? B GLY 340 ? B GLY 298 ? 1_555 CA ? I CA . ? B CA 501 ? 1_555 O   ? B ASN 386 ? B ASN 344 ? 1_555 172.0 ? 
29 OD2 ? B ASP 366 ? B ASP 324 ? 1_555 CA ? I CA . ? B CA 501 ? 1_555 O   ? B ASN 386 ? B ASN 344 ? 1_555 103.6 ? 
30 O   ? B GLY 384 ? B GLY 342 ? 1_555 CA ? I CA . ? B CA 501 ? 1_555 O   ? B ASN 386 ? B ASN 344 ? 1_555 89.0  ? 
31 O   ? B ASP 336 ? B ASP 294 ? 1_555 CA ? I CA . ? B CA 501 ? 1_555 O   ? N HOH .   ? B HOH 660 ? 1_555 174.5 ? 
32 O   ? B GLY 340 ? B GLY 298 ? 1_555 CA ? I CA . ? B CA 501 ? 1_555 O   ? N HOH .   ? B HOH 660 ? 1_555 89.8  ? 
33 OD2 ? B ASP 366 ? B ASP 324 ? 1_555 CA ? I CA . ? B CA 501 ? 1_555 O   ? N HOH .   ? B HOH 660 ? 1_555 90.2  ? 
34 O   ? B GLY 384 ? B GLY 342 ? 1_555 CA ? I CA . ? B CA 501 ? 1_555 O   ? N HOH .   ? B HOH 660 ? 1_555 82.8  ? 
35 O   ? B ASN 386 ? B ASN 344 ? 1_555 CA ? I CA . ? B CA 501 ? 1_555 O   ? N HOH .   ? B HOH 660 ? 1_555 92.8  ? 
36 OD1 ? B ASP 418 ? B ASP 376 ? 1_555 CA ? H CA . ? B CA 500 ? 1_555 OD2 ? B ASP 418 ? B ASP 376 ? 1_555 46.8  ? 
37 OD1 ? B ASP 418 ? B ASP 376 ? 1_555 CA ? H CA . ? B CA 500 ? 1_555 OD1 ? B ASN 420 ? B ASN 378 ? 1_555 75.0  ? 
38 OD2 ? B ASP 418 ? B ASP 376 ? 1_555 CA ? H CA . ? B CA 500 ? 1_555 OD1 ? B ASN 420 ? B ASN 378 ? 1_555 103.4 ? 
39 OD1 ? B ASP 418 ? B ASP 376 ? 1_555 CA ? H CA . ? B CA 500 ? 1_555 OD1 ? B ASP 426 ? B ASP 384 ? 1_555 169.0 ? 
40 OD2 ? B ASP 418 ? B ASP 376 ? 1_555 CA ? H CA . ? B CA 500 ? 1_555 OD1 ? B ASP 426 ? B ASP 384 ? 1_555 126.5 ? 
41 OD1 ? B ASN 420 ? B ASN 378 ? 1_555 CA ? H CA . ? B CA 500 ? 1_555 OD1 ? B ASP 426 ? B ASP 384 ? 1_555 115.9 ? 
42 OD1 ? B ASP 418 ? B ASP 376 ? 1_555 CA ? H CA . ? B CA 500 ? 1_555 O   ? B SER 428 ? B SER 386 ? 1_555 83.5  ? 
43 OD2 ? B ASP 418 ? B ASP 376 ? 1_555 CA ? H CA . ? B CA 500 ? 1_555 O   ? B SER 428 ? B SER 386 ? 1_555 87.3  ? 
44 OD1 ? B ASN 420 ? B ASN 378 ? 1_555 CA ? H CA . ? B CA 500 ? 1_555 O   ? B SER 428 ? B SER 386 ? 1_555 136.9 ? 
45 OD1 ? B ASP 426 ? B ASP 384 ? 1_555 CA ? H CA . ? B CA 500 ? 1_555 O   ? B SER 428 ? B SER 386 ? 1_555 87.6  ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1  NAG C .   ? ASN A 188 ? NAG C 1   ? 1_555 ASN A 146 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
2  NAG F .   ? ASN A 111 ? NAG A 502 ? 1_555 ASN A 69  ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
3  NAG G .   ? ASN A 130 ? NAG A 503 ? 1_555 ASN A 88  ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
4  NAG J .   ? ASN B 111 ? NAG B 502 ? 1_555 ASN B 69  ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
5  NAG K .   ? ASN B 130 ? NAG B 503 ? 1_555 ASN B 88  ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
6  NAG L .   ? ASN B 188 ? NAG B 504 ? 1_555 ASN B 146 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
7  CYS A 134 ? CYS A 459 ? CYS A 92  ? 1_555 CYS A 417 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
8  CYS A 166 ? CYS A 171 ? CYS A 124 ? 1_555 CYS A 129 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
9  CYS A 226 ? CYS A 273 ? CYS A 184 ? 1_555 CYS A 231 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
10 CYS A 275 ? CYS A 280 ? CYS A 233 ? 1_555 CYS A 238 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
11 CYS A 321 ? CYS A 334 ? CYS A 279 ? 1_555 CYS A 292 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
12 CYS A 323 ? CYS A 332 ? CYS A 281 ? 1_555 CYS A 290 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
13 CYS A 360 ? CYS A 377 ? CYS A 318 ? 1_555 CYS A 335 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
14 CYS A 463 ? CYS A 488 ? CYS A 421 ? 1_555 CYS A 446 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
15 CYS B 134 ? CYS B 459 ? CYS B 92  ? 1_555 CYS B 417 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
16 CYS B 166 ? CYS B 171 ? CYS B 124 ? 1_555 CYS B 129 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
17 CYS B 226 ? CYS B 273 ? CYS B 184 ? 1_555 CYS B 231 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
18 CYS B 275 ? CYS B 280 ? CYS B 233 ? 1_555 CYS B 238 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
19 CYS B 321 ? CYS B 334 ? CYS B 279 ? 1_555 CYS B 292 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
20 CYS B 323 ? CYS B 332 ? CYS B 281 ? 1_555 CYS B 290 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
21 CYS B 360 ? CYS B 377 ? CYS B 318 ? 1_555 CYS B 335 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
22 CYS B 463 ? CYS B 488 ? CYS B 421 ? 1_555 CYS B 446 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 ASN 367 A . ? ASN 325 A PRO 368 A ? PRO 326 A 1 -2.42 
2 ARG 472 A . ? ARG 430 A PRO 473 A ? PRO 431 A 1 -2.90 
3 LEU 505 A . ? LEU 463 A PRO 506 A ? PRO 464 A 1 -1.04 
4 ASN 367 B . ? ASN 325 B PRO 368 B ? PRO 326 B 1 -1.75 
5 ARG 472 B . ? ARG 430 B PRO 473 B ? PRO 431 B 1 -2.66 
6 LEU 505 B . ? LEU 463 B PRO 506 B ? PRO 464 B 1 -0.11 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 4 ? 
AA3 ? 4 ? 
AA4 ? 4 ? 
AA5 ? 4 ? 
AA6 ? 4 ? 
AA7 ? 4 ? 
AA8 ? 3 ? 
AA9 ? 4 ? 
AB1 ? 4 ? 
AB2 ? 4 ? 
AB3 ? 4 ? 
AB4 ? 4 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
AA7 1 2 ? anti-parallel 
AA7 2 3 ? anti-parallel 
AA7 3 4 ? anti-parallel 
AA8 1 2 ? anti-parallel 
AA8 2 3 ? anti-parallel 
AA9 1 2 ? anti-parallel 
AA9 2 3 ? anti-parallel 
AA9 3 4 ? anti-parallel 
AB1 1 2 ? anti-parallel 
AB1 2 3 ? anti-parallel 
AB1 3 4 ? anti-parallel 
AB2 1 2 ? anti-parallel 
AB2 2 3 ? anti-parallel 
AB2 3 4 ? anti-parallel 
AB3 1 2 ? anti-parallel 
AB3 2 3 ? anti-parallel 
AB3 3 4 ? anti-parallel 
AB4 1 2 ? anti-parallel 
AB4 2 3 ? anti-parallel 
AB4 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 GLY A 138 ? LYS A 144 ? GLY A 96  LYS A 102 
AA1 2 THR A 480 ? VAL A 490 ? THR A 438 VAL A 448 
AA1 3 ARG A 461 ? GLY A 471 ? ARG A 419 GLY A 429 
AA1 4 SER A 445 ? GLN A 450 ? SER A 403 GLN A 408 
AA2 1 PHE A 157 ? CYS A 166 ? PHE A 115 CYS A 124 
AA2 2 CYS A 171 ? LEU A 181 ? CYS A 129 LEU A 139 
AA2 3 THR A 199 ? PRO A 204 ? THR A 157 PRO A 162 
AA2 4 ARG A 215 ? VAL A 219 ? ARG A 173 VAL A 177 
AA3 1 SER A 222 ? HIS A 227 ? SER A 180 HIS A 185 
AA3 2 TRP A 232 ? SER A 238 ? TRP A 190 SER A 196 
AA3 3 VAL A 245 ? TYR A 250 ? VAL A 203 TYR A 208 
AA3 4 ILE A 253 ? LYS A 259 ? ILE A 211 LYS A 217 
AA4 1 ALA A 274 ? VAL A 276 ? ALA A 232 VAL A 234 
AA4 2 SER A 279 ? ASP A 286 ? SER A 237 ASP A 244 
AA4 3 SER A 294 ? GLU A 301 ? SER A 252 GLU A 259 
AA4 4 LYS A 304 ? GLU A 310 ? LYS A 262 GLU A 268 
AA5 1 GLU A 319 ? ASP A 326 ? GLU A 277 ASP A 284 
AA5 2 ASP A 329 ? ARG A 335 ? ASP A 287 ARG A 293 
AA5 3 PRO A 344 ? PHE A 348 ? PRO A 302 PHE A 306 
AA5 4 TYR A 354 ? TYR A 358 ? TYR A 312 TYR A 316 
AA6 1 SER A 392 ? TYR A 395 ? SER A 350 TYR A 353 
AA6 2 GLY A 398 ? ARG A 403 ? GLY A 356 ARG A 361 
AA6 3 ASN A 411 ? ASP A 418 ? ASN A 369 ASP A 376 
AA6 4 VAL A 431 ? TRP A 441 ? VAL A 389 TRP A 399 
AA7 1 GLY B 138 ? LYS B 144 ? GLY B 96  LYS B 102 
AA7 2 THR B 480 ? VAL B 490 ? THR B 438 VAL B 448 
AA7 3 ARG B 461 ? GLY B 471 ? ARG B 419 GLY B 429 
AA7 4 SER B 445 ? GLN B 450 ? SER B 403 GLN B 408 
AA8 1 PHE B 157 ? ARG B 160 ? PHE B 115 ARG B 118 
AA8 2 CYS B 171 ? LEU B 181 ? CYS B 129 LEU B 139 
AA8 3 ILE B 164 ? CYS B 166 ? ILE B 122 CYS B 124 
AA9 1 PHE B 157 ? ARG B 160 ? PHE B 115 ARG B 118 
AA9 2 CYS B 171 ? LEU B 181 ? CYS B 129 LEU B 139 
AA9 3 THR B 199 ? PRO B 204 ? THR B 157 PRO B 162 
AA9 4 ARG B 215 ? VAL B 219 ? ARG B 173 VAL B 177 
AB1 1 SER B 222 ? HIS B 227 ? SER B 180 HIS B 185 
AB1 2 TRP B 232 ? SER B 238 ? TRP B 190 SER B 196 
AB1 3 VAL B 245 ? TYR B 250 ? VAL B 203 TYR B 208 
AB1 4 ILE B 253 ? LYS B 259 ? ILE B 211 LYS B 217 
AB2 1 ALA B 274 ? VAL B 276 ? ALA B 232 VAL B 234 
AB2 2 SER B 279 ? ASP B 286 ? SER B 237 ASP B 244 
AB2 3 SER B 294 ? GLU B 301 ? SER B 252 GLU B 259 
AB2 4 LYS B 304 ? GLU B 310 ? LYS B 262 GLU B 268 
AB3 1 GLU B 319 ? ASP B 326 ? GLU B 277 ASP B 284 
AB3 2 ASP B 329 ? ARG B 335 ? ASP B 287 ARG B 293 
AB3 3 PRO B 344 ? PHE B 348 ? PRO B 302 PHE B 306 
AB3 4 TYR B 354 ? TYR B 358 ? TYR B 312 TYR B 316 
AB4 1 SER B 392 ? TYR B 395 ? SER B 350 TYR B 353 
AB4 2 GLY B 398 ? ARG B 403 ? GLY B 356 ARG B 361 
AB4 3 ASN B 411 ? ASP B 418 ? ASN B 369 ASP B 376 
AB4 4 VAL B 431 ? TRP B 441 ? VAL B 389 TRP B 399 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N TYR A 142 ? N TYR A 100 O SER A 486 ? O SER A 444 
AA1 2 3 O SER A 481 ? O SER A 439 N ARG A 470 ? N ARG A 428 
AA1 3 4 O CYS A 463 ? O CYS A 421 N PHE A 448 ? N PHE A 406 
AA2 1 2 N PHE A 163 ? N PHE A 121 O PHE A 174 ? O PHE A 132 
AA2 2 3 N THR A 173 ? N THR A 131 O CYS A 203 ? O CYS A 161 
AA2 3 4 N LEU A 200 ? N LEU A 158 O SER A 218 ? O SER A 176 
AA3 1 2 N CYS A 226 ? N CYS A 184 O LEU A 233 ? O LEU A 191 
AA3 2 3 N GLY A 236 ? N GLY A 194 O VAL A 247 ? O VAL A 205 
AA3 3 4 N ALA A 246 ? N ALA A 204 O ILE A 258 ? O ILE A 216 
AA4 1 2 N VAL A 276 ? N VAL A 234 O SER A 279 ? O SER A 237 
AA4 2 3 N CYS A 280 ? N CYS A 238 O ILE A 300 ? O ILE A 258 
AA4 3 4 N LYS A 299 ? N LYS A 257 O LYS A 307 ? O LYS A 265 
AA5 1 2 N SER A 322 ? N SER A 280 O VAL A 333 ? O VAL A 291 
AA5 2 3 N CYS A 334 ? N CYS A 292 O PRO A 344 ? O PRO A 302 
AA5 3 4 N TRP A 345 ? N TRP A 303 O GLY A 357 ? O GLY A 315 
AA6 1 2 N PHE A 393 ? N PHE A 351 O TRP A 400 ? O TRP A 358 
AA6 2 3 N ILE A 401 ? N ILE A 359 O ILE A 416 ? O ILE A 374 
AA6 3 4 N MET A 415 ? N MET A 373 O GLN A 433 ? O GLN A 391 
AA7 1 2 N ALA B 140 ? N ALA B 98  O CYS B 488 ? O CYS B 446 
AA7 2 3 O SER B 481 ? O SER B 439 N ARG B 470 ? N ARG B 428 
AA7 3 4 O CYS B 463 ? O CYS B 421 N PHE B 448 ? N PHE B 406 
AA8 1 2 N VAL B 158 ? N VAL B 116 O ALA B 180 ? O ALA B 138 
AA8 2 3 O ARG B 172 ? O ARG B 130 N SER B 165 ? N SER B 123 
AA9 1 2 N VAL B 158 ? N VAL B 116 O ALA B 180 ? O ALA B 138 
AA9 2 3 N THR B 173 ? N THR B 131 O CYS B 203 ? O CYS B 161 
AA9 3 4 N LEU B 200 ? N LEU B 158 O SER B 218 ? O SER B 176 
AB1 1 2 N CYS B 226 ? N CYS B 184 O LEU B 233 ? O LEU B 191 
AB1 2 3 N GLY B 236 ? N GLY B 194 O VAL B 247 ? O VAL B 205 
AB1 3 4 N VAL B 248 ? N VAL B 206 O THR B 255 ? O THR B 213 
AB2 1 2 N VAL B 276 ? N VAL B 234 O SER B 279 ? O SER B 237 
AB2 2 3 N CYS B 280 ? N CYS B 238 O ILE B 300 ? O ILE B 258 
AB2 3 4 N LYS B 299 ? N LYS B 257 O LYS B 307 ? O LYS B 265 
AB3 1 2 N SER B 322 ? N SER B 280 O VAL B 333 ? O VAL B 291 
AB3 2 3 N CYS B 334 ? N CYS B 292 O PRO B 344 ? O PRO B 302 
AB3 3 4 N TRP B 345 ? N TRP B 303 O GLY B 357 ? O GLY B 315 
AB4 1 2 N TYR B 395 ? N TYR B 353 O GLY B 398 ? O GLY B 356 
AB4 2 3 N ILE B 401 ? N ILE B 359 O ILE B 416 ? O ILE B 374 
AB4 3 4 N TRP B 417 ? N TRP B 375 O VAL B 431 ? O VAL B 389 
# 
_pdbx_entry_details.entry_id                   9GQT 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
_pdbx_validate_close_contact.id               1 
_pdbx_validate_close_contact.PDB_model_num    1 
_pdbx_validate_close_contact.auth_atom_id_1   O 
_pdbx_validate_close_contact.auth_asym_id_1   A 
_pdbx_validate_close_contact.auth_comp_id_1   VAL 
_pdbx_validate_close_contact.auth_seq_id_1    163 
_pdbx_validate_close_contact.PDB_ins_code_1   ? 
_pdbx_validate_close_contact.label_alt_id_1   ? 
_pdbx_validate_close_contact.auth_atom_id_2   O 
_pdbx_validate_close_contact.auth_asym_id_2   A 
_pdbx_validate_close_contact.auth_comp_id_2   HOH 
_pdbx_validate_close_contact.auth_seq_id_2    601 
_pdbx_validate_close_contact.PDB_ins_code_2   ? 
_pdbx_validate_close_contact.label_alt_id_2   ? 
_pdbx_validate_close_contact.dist             2.19 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 ILE A 223 ? ? 61.06   68.91   
2  1 THR A 226 ? ? -135.37 -151.46 
3  1 CYS A 292 ? ? -129.13 -165.88 
4  1 HIS A 297 ? ? -160.77 41.64   
5  1 ASN A 344 ? ? 61.40   -169.63 
6  1 SER A 400 ? ? -127.90 -140.67 
7  1 ASN A 449 ? ? -103.40 57.08   
8  1 TRP A 455 ? ? -164.53 -162.24 
9  1 TRP A 457 ? ? -116.88 77.92   
10 1 SER B 125 ? ? -89.53  -156.76 
11 1 ILE B 223 ? ? 61.43   67.88   
12 1 THR B 226 ? ? -134.42 -152.24 
13 1 CYS B 292 ? ? -129.57 -165.88 
14 1 HIS B 297 ? ? -160.82 40.73   
15 1 ASN B 344 ? ? 60.39   -168.60 
16 1 SER B 400 ? ? -127.41 -140.49 
17 1 ASN B 449 ? ? -101.01 56.93   
18 1 TRP B 455 ? ? -163.34 -164.67 
19 1 TRP B 457 ? ? -114.65 78.50   
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z   
2 -y,x,z  
3 y,-x,z  
4 -x,-y,z 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 954 ? 7.01  . 
2 1 O ? A HOH 955 ? 7.03  . 
3 1 O ? A HOH 956 ? 7.19  . 
4 1 O ? A HOH 957 ? 7.25  . 
5 1 O ? B HOH 935 ? 6.20  . 
6 1 O ? B HOH 936 ? 6.92  . 
7 1 O ? B HOH 937 ? 13.56 . 
8 1 O ? B HOH 938 ? 15.51 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A MET -41 ? A MET 1   
2   1 Y 1 A ASN -40 ? A ASN 2   
3   1 Y 1 A THR -39 ? A THR 3   
4   1 Y 1 A GLN -38 ? A GLN 4   
5   1 Y 1 A ILE -37 ? A ILE 5   
6   1 Y 1 A LEU -36 ? A LEU 6   
7   1 Y 1 A VAL -35 ? A VAL 7   
8   1 Y 1 A PHE -34 ? A PHE 8   
9   1 Y 1 A ALA -33 ? A ALA 9   
10  1 Y 1 A LEU -32 ? A LEU 10  
11  1 Y 1 A ILE -31 ? A ILE 11  
12  1 Y 1 A ALA -30 ? A ALA 12  
13  1 Y 1 A ILE -29 ? A ILE 13  
14  1 Y 1 A ILE -28 ? A ILE 14  
15  1 Y 1 A PRO -27 ? A PRO 15  
16  1 Y 1 A THR -26 ? A THR 16  
17  1 Y 1 A ASN -25 ? A ASN 17  
18  1 Y 1 A ALA -24 ? A ALA 18  
19  1 Y 1 A ASP -23 ? A ASP 19  
20  1 Y 1 A LYS -22 ? A LYS 20  
21  1 Y 1 A ILE -21 ? A ILE 21  
22  1 Y 1 A SER -20 ? A SER 22  
23  1 Y 1 A ALA -19 ? A ALA 23  
24  1 Y 1 A TRP -18 ? A TRP 24  
25  1 Y 1 A SER -17 ? A SER 25  
26  1 Y 1 A HIS -16 ? A HIS 26  
27  1 Y 1 A PRO -15 ? A PRO 27  
28  1 Y 1 A GLN -14 ? A GLN 28  
29  1 Y 1 A PHE -13 ? A PHE 29  
30  1 Y 1 A GLU -12 ? A GLU 30  
31  1 Y 1 A LYS -11 ? A LYS 31  
32  1 Y 1 A GLY -10 ? A GLY 32  
33  1 Y 1 A GLY -9  ? A GLY 33  
34  1 Y 1 A GLY -8  ? A GLY 34  
35  1 Y 1 A GLY -7  ? A GLY 35  
36  1 Y 1 A SER -6  ? A SER 36  
37  1 Y 1 A HIS -5  ? A HIS 37  
38  1 Y 1 A HIS -4  ? A HIS 38  
39  1 Y 1 A HIS -3  ? A HIS 39  
40  1 Y 1 A HIS -2  ? A HIS 40  
41  1 Y 1 A HIS -1  ? A HIS 41  
42  1 Y 1 A HIS 0   ? A HIS 42  
43  1 Y 1 A SER 1   ? A SER 43  
44  1 Y 1 A SER 2   ? A SER 44  
45  1 Y 1 A SER 3   ? A SER 45  
46  1 Y 1 A GLY 4   ? A GLY 46  
47  1 Y 1 A SER 5   ? A SER 47  
48  1 Y 1 A GLY 6   ? A GLY 48  
49  1 Y 1 A ALA 7   ? A ALA 49  
50  1 Y 1 A HIS 8   ? A HIS 50  
51  1 Y 1 A ILE 9   ? A ILE 51  
52  1 Y 1 A VAL 10  ? A VAL 52  
53  1 Y 1 A MET 11  ? A MET 53  
54  1 Y 1 A VAL 12  ? A VAL 54  
55  1 Y 1 A ASP 13  ? A ASP 55  
56  1 Y 1 A ALA 14  ? A ALA 56  
57  1 Y 1 A TYR 15  ? A TYR 57  
58  1 Y 1 A LYS 16  ? A LYS 58  
59  1 Y 1 A PRO 17  ? A PRO 59  
60  1 Y 1 A THR 18  ? A THR 60  
61  1 Y 1 A LYS 19  ? A LYS 61  
62  1 Y 1 A GLY 20  ? A GLY 62  
63  1 Y 1 A GLY 21  ? A GLY 63  
64  1 Y 1 A SER 22  ? A SER 64  
65  1 Y 1 A GLY 23  ? A GLY 65  
66  1 Y 1 A GLY 24  ? A GLY 66  
67  1 Y 1 A GLY 25  ? A GLY 67  
68  1 Y 1 A GLY 26  ? A GLY 68  
69  1 Y 1 A SER 27  ? A SER 69  
70  1 Y 1 A ILE 28  ? A ILE 70  
71  1 Y 1 A ILE 29  ? A ILE 71  
72  1 Y 1 A ASN 30  ? A ASN 72  
73  1 Y 1 A GLU 31  ? A GLU 73  
74  1 Y 1 A THR 32  ? A THR 74  
75  1 Y 1 A ALA 33  ? A ALA 75  
76  1 Y 1 A ASP 34  ? A ASP 76  
77  1 Y 1 A ASP 35  ? A ASP 77  
78  1 Y 1 A ILE 36  ? A ILE 78  
79  1 Y 1 A VAL 37  ? A VAL 79  
80  1 Y 1 A TYR 38  ? A TYR 80  
81  1 Y 1 A ARG 39  ? A ARG 81  
82  1 Y 1 A LEU 40  ? A LEU 82  
83  1 Y 1 A THR 41  ? A THR 83  
84  1 Y 1 A VAL 42  ? A VAL 84  
85  1 Y 1 A ILE 43  ? A ILE 85  
86  1 Y 1 A ILE 44  ? A ILE 86  
87  1 Y 1 A ASP 45  ? A ASP 87  
88  1 Y 1 A ASP 46  ? A ASP 88  
89  1 Y 1 A ARG 47  ? A ARG 89  
90  1 Y 1 A TYR 48  ? A TYR 90  
91  1 Y 1 A GLU 49  ? A GLU 91  
92  1 Y 1 A SER 50  ? A SER 92  
93  1 Y 1 A LEU 51  ? A LEU 93  
94  1 Y 1 A LYS 52  ? A LYS 94  
95  1 Y 1 A ASN 53  ? A ASN 95  
96  1 Y 1 A LEU 54  ? A LEU 96  
97  1 Y 1 B MET -41 ? B MET 1   
98  1 Y 1 B ASN -40 ? B ASN 2   
99  1 Y 1 B THR -39 ? B THR 3   
100 1 Y 1 B GLN -38 ? B GLN 4   
101 1 Y 1 B ILE -37 ? B ILE 5   
102 1 Y 1 B LEU -36 ? B LEU 6   
103 1 Y 1 B VAL -35 ? B VAL 7   
104 1 Y 1 B PHE -34 ? B PHE 8   
105 1 Y 1 B ALA -33 ? B ALA 9   
106 1 Y 1 B LEU -32 ? B LEU 10  
107 1 Y 1 B ILE -31 ? B ILE 11  
108 1 Y 1 B ALA -30 ? B ALA 12  
109 1 Y 1 B ILE -29 ? B ILE 13  
110 1 Y 1 B ILE -28 ? B ILE 14  
111 1 Y 1 B PRO -27 ? B PRO 15  
112 1 Y 1 B THR -26 ? B THR 16  
113 1 Y 1 B ASN -25 ? B ASN 17  
114 1 Y 1 B ALA -24 ? B ALA 18  
115 1 Y 1 B ASP -23 ? B ASP 19  
116 1 Y 1 B LYS -22 ? B LYS 20  
117 1 Y 1 B ILE -21 ? B ILE 21  
118 1 Y 1 B SER -20 ? B SER 22  
119 1 Y 1 B ALA -19 ? B ALA 23  
120 1 Y 1 B TRP -18 ? B TRP 24  
121 1 Y 1 B SER -17 ? B SER 25  
122 1 Y 1 B HIS -16 ? B HIS 26  
123 1 Y 1 B PRO -15 ? B PRO 27  
124 1 Y 1 B GLN -14 ? B GLN 28  
125 1 Y 1 B PHE -13 ? B PHE 29  
126 1 Y 1 B GLU -12 ? B GLU 30  
127 1 Y 1 B LYS -11 ? B LYS 31  
128 1 Y 1 B GLY -10 ? B GLY 32  
129 1 Y 1 B GLY -9  ? B GLY 33  
130 1 Y 1 B GLY -8  ? B GLY 34  
131 1 Y 1 B GLY -7  ? B GLY 35  
132 1 Y 1 B SER -6  ? B SER 36  
133 1 Y 1 B HIS -5  ? B HIS 37  
134 1 Y 1 B HIS -4  ? B HIS 38  
135 1 Y 1 B HIS -3  ? B HIS 39  
136 1 Y 1 B HIS -2  ? B HIS 40  
137 1 Y 1 B HIS -1  ? B HIS 41  
138 1 Y 1 B HIS 0   ? B HIS 42  
139 1 Y 1 B SER 1   ? B SER 43  
140 1 Y 1 B SER 2   ? B SER 44  
141 1 Y 1 B SER 3   ? B SER 45  
142 1 Y 1 B GLY 4   ? B GLY 46  
143 1 Y 1 B SER 5   ? B SER 47  
144 1 Y 1 B GLY 6   ? B GLY 48  
145 1 Y 1 B ALA 7   ? B ALA 49  
146 1 Y 1 B HIS 8   ? B HIS 50  
147 1 Y 1 B ILE 9   ? B ILE 51  
148 1 Y 1 B VAL 10  ? B VAL 52  
149 1 Y 1 B MET 11  ? B MET 53  
150 1 Y 1 B VAL 12  ? B VAL 54  
151 1 Y 1 B ASP 13  ? B ASP 55  
152 1 Y 1 B ALA 14  ? B ALA 56  
153 1 Y 1 B TYR 15  ? B TYR 57  
154 1 Y 1 B LYS 16  ? B LYS 58  
155 1 Y 1 B PRO 17  ? B PRO 59  
156 1 Y 1 B THR 18  ? B THR 60  
157 1 Y 1 B LYS 19  ? B LYS 61  
158 1 Y 1 B GLY 20  ? B GLY 62  
159 1 Y 1 B GLY 21  ? B GLY 63  
160 1 Y 1 B SER 22  ? B SER 64  
161 1 Y 1 B GLY 23  ? B GLY 65  
162 1 Y 1 B GLY 24  ? B GLY 66  
163 1 Y 1 B GLY 25  ? B GLY 67  
164 1 Y 1 B GLY 26  ? B GLY 68  
165 1 Y 1 B SER 27  ? B SER 69  
166 1 Y 1 B ILE 28  ? B ILE 70  
167 1 Y 1 B ILE 29  ? B ILE 71  
168 1 Y 1 B ASN 30  ? B ASN 72  
169 1 Y 1 B GLU 31  ? B GLU 73  
170 1 Y 1 B THR 32  ? B THR 74  
171 1 Y 1 B ALA 33  ? B ALA 75  
172 1 Y 1 B ASP 34  ? B ASP 76  
173 1 Y 1 B ASP 35  ? B ASP 77  
174 1 Y 1 B ILE 36  ? B ILE 78  
175 1 Y 1 B VAL 37  ? B VAL 79  
176 1 Y 1 B TYR 38  ? B TYR 80  
177 1 Y 1 B ARG 39  ? B ARG 81  
178 1 Y 1 B LEU 40  ? B LEU 82  
179 1 Y 1 B THR 41  ? B THR 83  
180 1 Y 1 B VAL 42  ? B VAL 84  
181 1 Y 1 B ILE 43  ? B ILE 85  
182 1 Y 1 B ILE 44  ? B ILE 86  
183 1 Y 1 B ASP 45  ? B ASP 87  
184 1 Y 1 B ASP 46  ? B ASP 88  
185 1 Y 1 B ARG 47  ? B ARG 89  
186 1 Y 1 B TYR 48  ? B TYR 90  
187 1 Y 1 B GLU 49  ? B GLU 91  
188 1 Y 1 B SER 50  ? B SER 92  
189 1 Y 1 B LEU 51  ? B LEU 93  
190 1 Y 1 B LYS 52  ? B LYS 94  
191 1 Y 1 B ASN 53  ? B ASN 95  
192 1 Y 1 B LEU 54  ? B LEU 96  
193 1 Y 1 B ILE 55  ? B ILE 97  
194 1 Y 1 B THR 56  ? B THR 98  
195 1 Y 1 B LEU 57  ? B LEU 99  
196 1 Y 1 B ARG 58  ? B ARG 100 
197 1 Y 1 B ALA 59  ? B ALA 101 
198 1 Y 1 B ASP 60  ? B ASP 102 
199 1 Y 1 B ARG 61  ? B ARG 103 
200 1 Y 1 B LEU 62  ? B LEU 104 
201 1 Y 1 B GLU 63  ? B GLU 105 
202 1 Y 1 B MET 64  ? B MET 106 
203 1 Y 1 B ILE 65  ? B ILE 107 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CA  CA   CA N N 74  
CYS N    N  N N 75  
CYS CA   C  N R 76  
CYS C    C  N N 77  
CYS O    O  N N 78  
CYS CB   C  N N 79  
CYS SG   S  N N 80  
CYS OXT  O  N N 81  
CYS H    H  N N 82  
CYS H2   H  N N 83  
CYS HA   H  N N 84  
CYS HB2  H  N N 85  
CYS HB3  H  N N 86  
CYS HG   H  N N 87  
CYS HXT  H  N N 88  
GLN N    N  N N 89  
GLN CA   C  N S 90  
GLN C    C  N N 91  
GLN O    O  N N 92  
GLN CB   C  N N 93  
GLN CG   C  N N 94  
GLN CD   C  N N 95  
GLN OE1  O  N N 96  
GLN NE2  N  N N 97  
GLN OXT  O  N N 98  
GLN H    H  N N 99  
GLN H2   H  N N 100 
GLN HA   H  N N 101 
GLN HB2  H  N N 102 
GLN HB3  H  N N 103 
GLN HG2  H  N N 104 
GLN HG3  H  N N 105 
GLN HE21 H  N N 106 
GLN HE22 H  N N 107 
GLN HXT  H  N N 108 
GLU N    N  N N 109 
GLU CA   C  N S 110 
GLU C    C  N N 111 
GLU O    O  N N 112 
GLU CB   C  N N 113 
GLU CG   C  N N 114 
GLU CD   C  N N 115 
GLU OE1  O  N N 116 
GLU OE2  O  N N 117 
GLU OXT  O  N N 118 
GLU H    H  N N 119 
GLU H2   H  N N 120 
GLU HA   H  N N 121 
GLU HB2  H  N N 122 
GLU HB3  H  N N 123 
GLU HG2  H  N N 124 
GLU HG3  H  N N 125 
GLU HE2  H  N N 126 
GLU HXT  H  N N 127 
GLY N    N  N N 128 
GLY CA   C  N N 129 
GLY C    C  N N 130 
GLY O    O  N N 131 
GLY OXT  O  N N 132 
GLY H    H  N N 133 
GLY H2   H  N N 134 
GLY HA2  H  N N 135 
GLY HA3  H  N N 136 
GLY HXT  H  N N 137 
HIS N    N  N N 138 
HIS CA   C  N S 139 
HIS C    C  N N 140 
HIS O    O  N N 141 
HIS CB   C  N N 142 
HIS CG   C  Y N 143 
HIS ND1  N  Y N 144 
HIS CD2  C  Y N 145 
HIS CE1  C  Y N 146 
HIS NE2  N  Y N 147 
HIS OXT  O  N N 148 
HIS H    H  N N 149 
HIS H2   H  N N 150 
HIS HA   H  N N 151 
HIS HB2  H  N N 152 
HIS HB3  H  N N 153 
HIS HD1  H  N N 154 
HIS HD2  H  N N 155 
HIS HE1  H  N N 156 
HIS HE2  H  N N 157 
HIS HXT  H  N N 158 
HOH O    O  N N 159 
HOH H1   H  N N 160 
HOH H2   H  N N 161 
ILE N    N  N N 162 
ILE CA   C  N S 163 
ILE C    C  N N 164 
ILE O    O  N N 165 
ILE CB   C  N S 166 
ILE CG1  C  N N 167 
ILE CG2  C  N N 168 
ILE CD1  C  N N 169 
ILE OXT  O  N N 170 
ILE H    H  N N 171 
ILE H2   H  N N 172 
ILE HA   H  N N 173 
ILE HB   H  N N 174 
ILE HG12 H  N N 175 
ILE HG13 H  N N 176 
ILE HG21 H  N N 177 
ILE HG22 H  N N 178 
ILE HG23 H  N N 179 
ILE HD11 H  N N 180 
ILE HD12 H  N N 181 
ILE HD13 H  N N 182 
ILE HXT  H  N N 183 
LEU N    N  N N 184 
LEU CA   C  N S 185 
LEU C    C  N N 186 
LEU O    O  N N 187 
LEU CB   C  N N 188 
LEU CG   C  N N 189 
LEU CD1  C  N N 190 
LEU CD2  C  N N 191 
LEU OXT  O  N N 192 
LEU H    H  N N 193 
LEU H2   H  N N 194 
LEU HA   H  N N 195 
LEU HB2  H  N N 196 
LEU HB3  H  N N 197 
LEU HG   H  N N 198 
LEU HD11 H  N N 199 
LEU HD12 H  N N 200 
LEU HD13 H  N N 201 
LEU HD21 H  N N 202 
LEU HD22 H  N N 203 
LEU HD23 H  N N 204 
LEU HXT  H  N N 205 
LYS N    N  N N 206 
LYS CA   C  N S 207 
LYS C    C  N N 208 
LYS O    O  N N 209 
LYS CB   C  N N 210 
LYS CG   C  N N 211 
LYS CD   C  N N 212 
LYS CE   C  N N 213 
LYS NZ   N  N N 214 
LYS OXT  O  N N 215 
LYS H    H  N N 216 
LYS H2   H  N N 217 
LYS HA   H  N N 218 
LYS HB2  H  N N 219 
LYS HB3  H  N N 220 
LYS HG2  H  N N 221 
LYS HG3  H  N N 222 
LYS HD2  H  N N 223 
LYS HD3  H  N N 224 
LYS HE2  H  N N 225 
LYS HE3  H  N N 226 
LYS HZ1  H  N N 227 
LYS HZ2  H  N N 228 
LYS HZ3  H  N N 229 
LYS HXT  H  N N 230 
MET N    N  N N 231 
MET CA   C  N S 232 
MET C    C  N N 233 
MET O    O  N N 234 
MET CB   C  N N 235 
MET CG   C  N N 236 
MET SD   S  N N 237 
MET CE   C  N N 238 
MET OXT  O  N N 239 
MET H    H  N N 240 
MET H2   H  N N 241 
MET HA   H  N N 242 
MET HB2  H  N N 243 
MET HB3  H  N N 244 
MET HG2  H  N N 245 
MET HG3  H  N N 246 
MET HE1  H  N N 247 
MET HE2  H  N N 248 
MET HE3  H  N N 249 
MET HXT  H  N N 250 
NAG C1   C  N R 251 
NAG C2   C  N R 252 
NAG C3   C  N R 253 
NAG C4   C  N S 254 
NAG C5   C  N R 255 
NAG C6   C  N N 256 
NAG C7   C  N N 257 
NAG C8   C  N N 258 
NAG N2   N  N N 259 
NAG O1   O  N N 260 
NAG O3   O  N N 261 
NAG O4   O  N N 262 
NAG O5   O  N N 263 
NAG O6   O  N N 264 
NAG O7   O  N N 265 
NAG H1   H  N N 266 
NAG H2   H  N N 267 
NAG H3   H  N N 268 
NAG H4   H  N N 269 
NAG H5   H  N N 270 
NAG H61  H  N N 271 
NAG H62  H  N N 272 
NAG H81  H  N N 273 
NAG H82  H  N N 274 
NAG H83  H  N N 275 
NAG HN2  H  N N 276 
NAG HO1  H  N N 277 
NAG HO3  H  N N 278 
NAG HO4  H  N N 279 
NAG HO6  H  N N 280 
PHE N    N  N N 281 
PHE CA   C  N S 282 
PHE C    C  N N 283 
PHE O    O  N N 284 
PHE CB   C  N N 285 
PHE CG   C  Y N 286 
PHE CD1  C  Y N 287 
PHE CD2  C  Y N 288 
PHE CE1  C  Y N 289 
PHE CE2  C  Y N 290 
PHE CZ   C  Y N 291 
PHE OXT  O  N N 292 
PHE H    H  N N 293 
PHE H2   H  N N 294 
PHE HA   H  N N 295 
PHE HB2  H  N N 296 
PHE HB3  H  N N 297 
PHE HD1  H  N N 298 
PHE HD2  H  N N 299 
PHE HE1  H  N N 300 
PHE HE2  H  N N 301 
PHE HZ   H  N N 302 
PHE HXT  H  N N 303 
PRO N    N  N N 304 
PRO CA   C  N S 305 
PRO C    C  N N 306 
PRO O    O  N N 307 
PRO CB   C  N N 308 
PRO CG   C  N N 309 
PRO CD   C  N N 310 
PRO OXT  O  N N 311 
PRO H    H  N N 312 
PRO HA   H  N N 313 
PRO HB2  H  N N 314 
PRO HB3  H  N N 315 
PRO HG2  H  N N 316 
PRO HG3  H  N N 317 
PRO HD2  H  N N 318 
PRO HD3  H  N N 319 
PRO HXT  H  N N 320 
SER N    N  N N 321 
SER CA   C  N S 322 
SER C    C  N N 323 
SER O    O  N N 324 
SER CB   C  N N 325 
SER OG   O  N N 326 
SER OXT  O  N N 327 
SER H    H  N N 328 
SER H2   H  N N 329 
SER HA   H  N N 330 
SER HB2  H  N N 331 
SER HB3  H  N N 332 
SER HG   H  N N 333 
SER HXT  H  N N 334 
THR N    N  N N 335 
THR CA   C  N S 336 
THR C    C  N N 337 
THR O    O  N N 338 
THR CB   C  N R 339 
THR OG1  O  N N 340 
THR CG2  C  N N 341 
THR OXT  O  N N 342 
THR H    H  N N 343 
THR H2   H  N N 344 
THR HA   H  N N 345 
THR HB   H  N N 346 
THR HG1  H  N N 347 
THR HG21 H  N N 348 
THR HG22 H  N N 349 
THR HG23 H  N N 350 
THR HXT  H  N N 351 
TRP N    N  N N 352 
TRP CA   C  N S 353 
TRP C    C  N N 354 
TRP O    O  N N 355 
TRP CB   C  N N 356 
TRP CG   C  Y N 357 
TRP CD1  C  Y N 358 
TRP CD2  C  Y N 359 
TRP NE1  N  Y N 360 
TRP CE2  C  Y N 361 
TRP CE3  C  Y N 362 
TRP CZ2  C  Y N 363 
TRP CZ3  C  Y N 364 
TRP CH2  C  Y N 365 
TRP OXT  O  N N 366 
TRP H    H  N N 367 
TRP H2   H  N N 368 
TRP HA   H  N N 369 
TRP HB2  H  N N 370 
TRP HB3  H  N N 371 
TRP HD1  H  N N 372 
TRP HE1  H  N N 373 
TRP HE3  H  N N 374 
TRP HZ2  H  N N 375 
TRP HZ3  H  N N 376 
TRP HH2  H  N N 377 
TRP HXT  H  N N 378 
TYR N    N  N N 379 
TYR CA   C  N S 380 
TYR C    C  N N 381 
TYR O    O  N N 382 
TYR CB   C  N N 383 
TYR CG   C  Y N 384 
TYR CD1  C  Y N 385 
TYR CD2  C  Y N 386 
TYR CE1  C  Y N 387 
TYR CE2  C  Y N 388 
TYR CZ   C  Y N 389 
TYR OH   O  N N 390 
TYR OXT  O  N N 391 
TYR H    H  N N 392 
TYR H2   H  N N 393 
TYR HA   H  N N 394 
TYR HB2  H  N N 395 
TYR HB3  H  N N 396 
TYR HD1  H  N N 397 
TYR HD2  H  N N 398 
TYR HE1  H  N N 399 
TYR HE2  H  N N 400 
TYR HH   H  N N 401 
TYR HXT  H  N N 402 
VAL N    N  N N 403 
VAL CA   C  N S 404 
VAL C    C  N N 405 
VAL O    O  N N 406 
VAL CB   C  N N 407 
VAL CG1  C  N N 408 
VAL CG2  C  N N 409 
VAL OXT  O  N N 410 
VAL H    H  N N 411 
VAL H2   H  N N 412 
VAL HA   H  N N 413 
VAL HB   H  N N 414 
VAL HG11 H  N N 415 
VAL HG12 H  N N 416 
VAL HG13 H  N N 417 
VAL HG21 H  N N 418 
VAL HG22 H  N N 419 
VAL HG23 H  N N 420 
VAL HXT  H  N N 421 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
NAG C1  C2   sing N N 237 
NAG C1  O1   sing N N 238 
NAG C1  O5   sing N N 239 
NAG C1  H1   sing N N 240 
NAG C2  C3   sing N N 241 
NAG C2  N2   sing N N 242 
NAG C2  H2   sing N N 243 
NAG C3  C4   sing N N 244 
NAG C3  O3   sing N N 245 
NAG C3  H3   sing N N 246 
NAG C4  C5   sing N N 247 
NAG C4  O4   sing N N 248 
NAG C4  H4   sing N N 249 
NAG C5  C6   sing N N 250 
NAG C5  O5   sing N N 251 
NAG C5  H5   sing N N 252 
NAG C6  O6   sing N N 253 
NAG C6  H61  sing N N 254 
NAG C6  H62  sing N N 255 
NAG C7  C8   sing N N 256 
NAG C7  N2   sing N N 257 
NAG C7  O7   doub N N 258 
NAG C8  H81  sing N N 259 
NAG C8  H82  sing N N 260 
NAG C8  H83  sing N N 261 
NAG N2  HN2  sing N N 262 
NAG O1  HO1  sing N N 263 
NAG O3  HO3  sing N N 264 
NAG O4  HO4  sing N N 265 
NAG O6  HO6  sing N N 266 
PHE N   CA   sing N N 267 
PHE N   H    sing N N 268 
PHE N   H2   sing N N 269 
PHE CA  C    sing N N 270 
PHE CA  CB   sing N N 271 
PHE CA  HA   sing N N 272 
PHE C   O    doub N N 273 
PHE C   OXT  sing N N 274 
PHE CB  CG   sing N N 275 
PHE CB  HB2  sing N N 276 
PHE CB  HB3  sing N N 277 
PHE CG  CD1  doub Y N 278 
PHE CG  CD2  sing Y N 279 
PHE CD1 CE1  sing Y N 280 
PHE CD1 HD1  sing N N 281 
PHE CD2 CE2  doub Y N 282 
PHE CD2 HD2  sing N N 283 
PHE CE1 CZ   doub Y N 284 
PHE CE1 HE1  sing N N 285 
PHE CE2 CZ   sing Y N 286 
PHE CE2 HE2  sing N N 287 
PHE CZ  HZ   sing N N 288 
PHE OXT HXT  sing N N 289 
PRO N   CA   sing N N 290 
PRO N   CD   sing N N 291 
PRO N   H    sing N N 292 
PRO CA  C    sing N N 293 
PRO CA  CB   sing N N 294 
PRO CA  HA   sing N N 295 
PRO C   O    doub N N 296 
PRO C   OXT  sing N N 297 
PRO CB  CG   sing N N 298 
PRO CB  HB2  sing N N 299 
PRO CB  HB3  sing N N 300 
PRO CG  CD   sing N N 301 
PRO CG  HG2  sing N N 302 
PRO CG  HG3  sing N N 303 
PRO CD  HD2  sing N N 304 
PRO CD  HD3  sing N N 305 
PRO OXT HXT  sing N N 306 
SER N   CA   sing N N 307 
SER N   H    sing N N 308 
SER N   H2   sing N N 309 
SER CA  C    sing N N 310 
SER CA  CB   sing N N 311 
SER CA  HA   sing N N 312 
SER C   O    doub N N 313 
SER C   OXT  sing N N 314 
SER CB  OG   sing N N 315 
SER CB  HB2  sing N N 316 
SER CB  HB3  sing N N 317 
SER OG  HG   sing N N 318 
SER OXT HXT  sing N N 319 
THR N   CA   sing N N 320 
THR N   H    sing N N 321 
THR N   H2   sing N N 322 
THR CA  C    sing N N 323 
THR CA  CB   sing N N 324 
THR CA  HA   sing N N 325 
THR C   O    doub N N 326 
THR C   OXT  sing N N 327 
THR CB  OG1  sing N N 328 
THR CB  CG2  sing N N 329 
THR CB  HB   sing N N 330 
THR OG1 HG1  sing N N 331 
THR CG2 HG21 sing N N 332 
THR CG2 HG22 sing N N 333 
THR CG2 HG23 sing N N 334 
THR OXT HXT  sing N N 335 
TRP N   CA   sing N N 336 
TRP N   H    sing N N 337 
TRP N   H2   sing N N 338 
TRP CA  C    sing N N 339 
TRP CA  CB   sing N N 340 
TRP CA  HA   sing N N 341 
TRP C   O    doub N N 342 
TRP C   OXT  sing N N 343 
TRP CB  CG   sing N N 344 
TRP CB  HB2  sing N N 345 
TRP CB  HB3  sing N N 346 
TRP CG  CD1  doub Y N 347 
TRP CG  CD2  sing Y N 348 
TRP CD1 NE1  sing Y N 349 
TRP CD1 HD1  sing N N 350 
TRP CD2 CE2  doub Y N 351 
TRP CD2 CE3  sing Y N 352 
TRP NE1 CE2  sing Y N 353 
TRP NE1 HE1  sing N N 354 
TRP CE2 CZ2  sing Y N 355 
TRP CE3 CZ3  doub Y N 356 
TRP CE3 HE3  sing N N 357 
TRP CZ2 CH2  doub Y N 358 
TRP CZ2 HZ2  sing N N 359 
TRP CZ3 CH2  sing Y N 360 
TRP CZ3 HZ3  sing N N 361 
TRP CH2 HH2  sing N N 362 
TRP OXT HXT  sing N N 363 
TYR N   CA   sing N N 364 
TYR N   H    sing N N 365 
TYR N   H2   sing N N 366 
TYR CA  C    sing N N 367 
TYR CA  CB   sing N N 368 
TYR CA  HA   sing N N 369 
TYR C   O    doub N N 370 
TYR C   OXT  sing N N 371 
TYR CB  CG   sing N N 372 
TYR CB  HB2  sing N N 373 
TYR CB  HB3  sing N N 374 
TYR CG  CD1  doub Y N 375 
TYR CG  CD2  sing Y N 376 
TYR CD1 CE1  sing Y N 377 
TYR CD1 HD1  sing N N 378 
TYR CD2 CE2  doub Y N 379 
TYR CD2 HD2  sing N N 380 
TYR CE1 CZ   doub Y N 381 
TYR CE1 HE1  sing N N 382 
TYR CE2 CZ   sing Y N 383 
TYR CE2 HE2  sing N N 384 
TYR CZ  OH   sing N N 385 
TYR OH  HH   sing N N 386 
TYR OXT HXT  sing N N 387 
VAL N   CA   sing N N 388 
VAL N   H    sing N N 389 
VAL N   H2   sing N N 390 
VAL CA  C    sing N N 391 
VAL CA  CB   sing N N 392 
VAL CA  HA   sing N N 393 
VAL C   O    doub N N 394 
VAL C   OXT  sing N N 395 
VAL CB  CG1  sing N N 396 
VAL CB  CG2  sing N N 397 
VAL CB  HB   sing N N 398 
VAL CG1 HG11 sing N N 399 
VAL CG1 HG12 sing N N 400 
VAL CG1 HG13 sing N N 401 
VAL CG2 HG21 sing N N 402 
VAL CG2 HG22 sing N N 403 
VAL CG2 HG23 sing N N 404 
VAL OXT HXT  sing N N 405 
# 
_pdbx_audit_support.funding_organization   'Medical Research Council (MRC, United Kingdom)' 
_pdbx_audit_support.country                'United Kingdom' 
_pdbx_audit_support.grant_number           MR/S007555/1 
_pdbx_audit_support.ordinal                1 
# 
loop_
_pdbx_entity_branch_list.entity_id 
_pdbx_entity_branch_list.comp_id 
_pdbx_entity_branch_list.num 
_pdbx_entity_branch_list.hetero 
2 NAG 1 n 
2 NAG 2 n 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   4b7q 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 4' 
_space_group.name_Hall        'P 4' 
_space_group.IT_number        75 
_space_group.crystal_system   tetragonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    9GQT 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.010859 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.010859 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.006812 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C  ? ? 3.54356  2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
CA ? ? 16.26893 3.65395 ? ? 3.58509  77.28589 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N  ? ? 4.01032  2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O  ? ? 4.49882  3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S  ? ? 9.55732  6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . ILE A 1 97  ? 45.30941 40.03645  20.30940   1.000 68.58423  ? 55  ILE A N   1 
ATOM   2    C  CA  . ILE A 1 97  ? 46.15754 40.90037  19.48534   1.000 72.35931  ? 55  ILE A CA  1 
ATOM   3    C  C   . ILE A 1 97  ? 46.92798 40.08143  18.47243   1.000 79.33313  ? 55  ILE A C   1 
ATOM   4    O  O   . ILE A 1 97  ? 46.99863 40.43962  17.29695   1.000 82.95404  ? 55  ILE A O   1 
ATOM   5    C  CB  . ILE A 1 97  ? 47.15254 41.72801  20.32585   1.000 70.11681  ? 55  ILE A CB  1 
ATOM   6    C  CG1 . ILE A 1 97  ? 46.41591 42.68025  21.25600   1.000 69.59301  ? 55  ILE A CG1 1 
ATOM   7    C  CG2 . ILE A 1 97  ? 48.09070 42.53783  19.42259   1.000 49.58936  ? 55  ILE A CG2 1 
ATOM   8    C  CD1 . ILE A 1 97  ? 47.34514 43.56798  22.03930   1.000 57.83744  ? 55  ILE A CD1 1 
ATOM   9    N  N   . THR A 1 98  ? 47.53931 38.99070  18.94098   1.000 81.34541  ? 56  THR A N   1 
ATOM   10   C  CA  . THR A 1 98  ? 48.28999 38.12926  18.03312   1.000 79.16911  ? 56  THR A CA  1 
ATOM   11   C  C   . THR A 1 98  ? 47.36077 37.41282  17.05937   1.000 81.94730  ? 56  THR A C   1 
ATOM   12   O  O   . THR A 1 98  ? 47.75158 37.14394  15.91782   1.000 80.49377  ? 56  THR A O   1 
ATOM   13   C  CB  . THR A 1 98  ? 49.13432 37.11796  18.82319   1.000 80.95891  ? 56  THR A CB  1 
ATOM   14   O  OG1 . THR A 1 98  ? 49.84118 37.78948  19.87507   1.000 71.31707  ? 56  THR A OG1 1 
ATOM   15   C  CG2 . THR A 1 98  ? 50.15516 36.43613  17.91559   1.000 69.80089  ? 56  THR A CG2 1 
ATOM   16   N  N   . LEU A 1 99  ? 46.12570 37.11849  17.47729   1.000 85.52092  ? 57  LEU A N   1 
ATOM   17   C  CA  . LEU A 1 99  ? 45.17336 36.49064  16.56664   1.000 81.04099  ? 57  LEU A CA  1 
ATOM   18   C  C   . LEU A 1 99  ? 44.76064 37.44889  15.45381   1.000 79.77797  ? 57  LEU A C   1 
ATOM   19   O  O   . LEU A 1 99  ? 44.78117 37.08335  14.27285   1.000 79.36320  ? 57  LEU A O   1 
ATOM   20   C  CB  . LEU A 1 99  ? 43.94404 36.00292  17.33461   1.000 86.05373  ? 57  LEU A CB  1 
ATOM   21   C  CG  . LEU A 1 99  ? 42.90568 35.24951  16.49556   1.000 82.62354  ? 57  LEU A CG  1 
ATOM   22   C  CD1 . LEU A 1 99  ? 43.31133 33.77721  16.32692   1.000 75.39606  ? 57  LEU A CD1 1 
ATOM   23   C  CD2 . LEU A 1 99  ? 41.48413 35.40021  17.06402   1.000 76.63319  ? 57  LEU A CD2 1 
ATOM   24   N  N   . ARG A 1 100 ? 44.38398 38.68515  15.81025   1.000 80.23839  ? 58  ARG A N   1 
ATOM   25   C  CA  . ARG A 1 100 ? 43.90255 39.62982  14.80312   1.000 75.95660  ? 58  ARG A CA  1 
ATOM   26   C  C   . ARG A 1 100 ? 45.02915 40.14629  13.91738   1.000 73.59556  ? 58  ARG A C   1 
ATOM   27   O  O   . ARG A 1 100 ? 44.78961 40.48002  12.75080   1.000 74.52572  ? 58  ARG A O   1 
ATOM   28   C  CB  . ARG A 1 100 ? 43.18252 40.80177  15.46933   1.000 75.60142  ? 58  ARG A CB  1 
ATOM   29   C  CG  . ARG A 1 100 ? 41.97632 40.40058  16.29277   1.000 71.02494  ? 58  ARG A CG  1 
ATOM   30   C  CD  . ARG A 1 100 ? 41.14661 39.32918  15.58784   1.000 77.48926  ? 58  ARG A CD  1 
ATOM   31   N  NE  . ARG A 1 100 ? 40.56507 39.78733  14.33018   1.000 79.49863  ? 58  ARG A NE  1 
ATOM   32   C  CZ  . ARG A 1 100 ? 39.43966 40.48541  14.23437   1.000 77.50983  ? 58  ARG A CZ  1 
ATOM   33   N  NH1 . ARG A 1 100 ? 38.76754 40.86697  15.30808   1.000 70.49830  ? 58  ARG A NH1 1 
ATOM   34   N  NH2 . ARG A 1 100 ? 38.97765 40.81232  13.03069   1.000 75.59964  ? 58  ARG A NH2 1 
ATOM   35   N  N   . ALA A 1 101 ? 46.25476 40.21930  14.44511   1.000 70.11531  ? 59  ALA A N   1 
ATOM   36   C  CA  . ALA A 1 101 ? 47.38768 40.67562  13.64491   1.000 76.66837  ? 59  ALA A CA  1 
ATOM   37   C  C   . ALA A 1 101 ? 47.84943 39.60533  12.65593   1.000 78.20280  ? 59  ALA A C   1 
ATOM   38   O  O   . ALA A 1 101 ? 48.20933 39.92858  11.51825   1.000 75.71057  ? 59  ALA A O   1 
ATOM   39   C  CB  . ALA A 1 101 ? 48.53570 41.10421  14.55917   1.000 65.38391  ? 59  ALA A CB  1 
ATOM   40   N  N   . ASP A 1 102 ? 47.84561 38.32897  13.06902   1.000 78.62812  ? 60  ASP A N   1 
ATOM   41   C  CA  . ASP A 1 102 ? 48.12761 37.23031  12.14211   1.000 74.96310  ? 60  ASP A CA  1 
ATOM   42   C  C   . ASP A 1 102 ? 46.98325 37.00533  11.15720   1.000 73.85341  ? 60  ASP A C   1 
ATOM   43   O  O   . ASP A 1 102 ? 47.21201 36.53051  10.03878   1.000 69.38742  ? 60  ASP A O   1 
ATOM   44   C  CB  . ASP A 1 102 ? 48.39952 35.93203  12.91012   1.000 79.82401  ? 60  ASP A CB  1 
ATOM   45   C  CG  . ASP A 1 102 ? 49.70511 35.96779  13.69330   1.000 86.33486  ? 60  ASP A CG  1 
ATOM   46   O  OD1 . ASP A 1 102 ? 50.61796 36.73152  13.30700   1.000 87.68033  ? 60  ASP A OD1 1 
ATOM   47   O  OD2 . ASP A 1 102 ? 49.81891 35.22199  14.69278   1.000 77.99307  ? 60  ASP A OD2 1 
ATOM   48   N  N   . ARG A 1 103 ? 45.74768 37.31627  11.55589   1.000 73.25493  ? 61  ARG A N   1 
ATOM   49   C  CA  . ARG A 1 103 ? 44.62704 37.20747  10.62898   1.000 74.35556  ? 61  ARG A CA  1 
ATOM   50   C  C   . ARG A 1 103 ? 44.70485 38.26945  9.53150    1.000 80.03649  ? 61  ARG A C   1 
ATOM   51   O  O   . ARG A 1 103 ? 44.32360 38.00238  8.38525    1.000 77.96984  ? 61  ARG A O   1 
ATOM   52   C  CB  . ARG A 1 103 ? 43.30583 37.29703  11.40290   1.000 77.39777  ? 61  ARG A CB  1 
ATOM   53   C  CG  . ARG A 1 103 ? 42.07580 36.89727  10.61522   1.000 76.65538  ? 61  ARG A CG  1 
ATOM   54   C  CD  . ARG A 1 103 ? 40.83815 36.78638  11.50782   1.000 80.63998  ? 61  ARG A CD  1 
ATOM   55   N  NE  . ARG A 1 103 ? 39.60286 36.92665  10.74112   1.000 78.97797  ? 61  ARG A NE  1 
ATOM   56   C  CZ  . ARG A 1 103 ? 39.08598 35.98334  9.96420    1.000 72.88999  ? 61  ARG A CZ  1 
ATOM   57   N  NH1 . ARG A 1 103 ? 39.66263 34.79833  9.83720    1.000 78.00143  ? 61  ARG A NH1 1 
ATOM   58   N  NH2 . ARG A 1 103 ? 37.96581 36.23734  9.29216    1.000 72.40065  ? 61  ARG A NH2 1 
ATOM   59   N  N   . LEU A 1 104 ? 45.21533 39.46640  9.84747    1.000 74.06073  ? 62  LEU A N   1 
ATOM   60   C  CA  . LEU A 1 104 ? 45.36917 40.49014  8.81703    1.000 68.27639  ? 62  LEU A CA  1 
ATOM   61   C  C   . LEU A 1 104 ? 46.50893 40.16443  7.85353    1.000 67.40698  ? 62  LEU A C   1 
ATOM   62   O  O   . LEU A 1 104 ? 46.39970 40.46430  6.65880    1.000 62.73927  ? 62  LEU A O   1 
ATOM   63   C  CB  . LEU A 1 104 ? 45.58272 41.85948  9.46258    1.000 71.70018  ? 62  LEU A CB  1 
ATOM   64   C  CG  . LEU A 1 104 ? 44.33535 42.48241  10.09539   1.000 78.59821  ? 62  LEU A CG  1 
ATOM   65   C  CD1 . LEU A 1 104 ? 44.69572 43.71495  10.91495   1.000 82.09344  ? 62  LEU A CD1 1 
ATOM   66   C  CD2 . LEU A 1 104 ? 43.30429 42.83279  9.02738    1.000 75.84807  ? 62  LEU A CD2 1 
ATOM   67   N  N   . GLU A 1 105 ? 47.59425 39.54006  8.34335    1.000 65.22055  ? 63  GLU A N   1 
ATOM   68   C  CA  . GLU A 1 105 ? 48.73028 39.20345  7.48116    1.000 61.59326  ? 63  GLU A CA  1 
ATOM   69   C  C   . GLU A 1 105 ? 48.36361 38.14578  6.44233    1.000 63.91595  ? 63  GLU A C   1 
ATOM   70   O  O   . GLU A 1 105 ? 48.85855 38.18366  5.31028    1.000 65.30030  ? 63  GLU A O   1 
ATOM   71   C  CB  . GLU A 1 105 ? 49.92007 38.73136  8.32242    1.000 58.54538  ? 63  GLU A CB  1 
ATOM   72   C  CG  . GLU A 1 105 ? 50.35681 39.73434  9.37130    1.000 73.00113  ? 63  GLU A CG  1 
ATOM   73   C  CD  . GLU A 1 105 ? 51.85299 39.72245  9.64082    1.000 81.94449  ? 63  GLU A CD  1 
ATOM   74   O  OE1 . GLU A 1 105 ? 52.51839 38.72622  9.27883    1.000 77.93404  ? 63  GLU A OE1 1 
ATOM   75   O  OE2 . GLU A 1 105 ? 52.36018 40.72176  10.20997   1.000 76.70266  ? 63  GLU A OE2 1 
ATOM   76   N  N   . MET A 1 106 ? 47.50608 37.18863  6.80375    1.000 72.86493  ? 64  MET A N   1 
ATOM   77   C  CA  . MET A 1 106 ? 47.04102 36.21155  5.82153    1.000 72.79747  ? 64  MET A CA  1 
ATOM   78   C  C   . MET A 1 106 ? 46.10110 36.85364  4.79983    1.000 70.77018  ? 64  MET A C   1 
ATOM   79   O  O   . MET A 1 106 ? 46.19387 36.57166  3.60039    1.000 70.55407  ? 64  MET A O   1 
ATOM   80   C  CB  . MET A 1 106 ? 46.35704 35.03575  6.53222    1.000 81.54227  ? 64  MET A CB  1 
ATOM   81   C  CG  . MET A 1 106 ? 45.95596 33.87365  5.60726    1.000 89.88678  ? 64  MET A CG  1 
ATOM   82   S  SD  . MET A 1 106 ? 45.47384 32.33544  6.44040    1.000 118.95708 ? 64  MET A SD  1 
ATOM   83   C  CE  . MET A 1 106 ? 43.76167 32.65284  6.87101    1.000 83.98958  ? 64  MET A CE  1 
ATOM   84   N  N   . ILE A 1 107 ? 45.19449 37.72400  5.25092    1.000 65.23865  ? 65  ILE A N   1 
ATOM   85   C  CA  . ILE A 1 107 ? 44.26594 38.37678  4.33105    1.000 62.04109  ? 65  ILE A CA  1 
ATOM   86   C  C   . ILE A 1 107 ? 45.01841 39.24303  3.32671    1.000 61.88950  ? 65  ILE A C   1 
ATOM   87   O  O   . ILE A 1 107 ? 44.70062 39.25308  2.13198    1.000 59.45136  ? 65  ILE A O   1 
ATOM   88   C  CB  . ILE A 1 107 ? 43.23162 39.19325  5.12406    1.000 66.48862  ? 65  ILE A CB  1 
ATOM   89   C  CG1 . ILE A 1 107 ? 42.37573 38.25564  5.97790    1.000 63.61614  ? 65  ILE A CG1 1 
ATOM   90   C  CG2 . ILE A 1 107 ? 42.37774 40.03301  4.18567    1.000 65.62029  ? 65  ILE A CG2 1 
ATOM   91   C  CD1 . ILE A 1 107 ? 41.57195 38.95848  7.04533    1.000 63.03851  ? 65  ILE A CD1 1 
ATOM   92   N  N   . ILE A 1 108 ? 46.03397 39.97401  3.78754    1.000 66.59836  ? 66  ILE A N   1 
ATOM   93   C  CA  . ILE A 1 108 ? 46.81176 40.80891  2.87789    1.000 60.00386  ? 66  ILE A CA  1 
ATOM   94   C  C   . ILE A 1 108 ? 47.58742 39.94620  1.88519    1.000 60.35427  ? 66  ILE A C   1 
ATOM   95   O  O   . ILE A 1 108 ? 47.47820 40.12863  0.66832    1.000 60.21883  ? 66  ILE A O   1 
ATOM   96   C  CB  . ILE A 1 108 ? 47.74514 41.74053  3.66365    1.000 54.75474  ? 66  ILE A CB  1 
ATOM   97   C  CG1 . ILE A 1 108 ? 46.91571 42.68865  4.52420    1.000 52.90933  ? 66  ILE A CG1 1 
ATOM   98   C  CG2 . ILE A 1 108 ? 48.61432 42.52825  2.68493    1.000 44.28126  ? 66  ILE A CG2 1 
ATOM   99   C  CD1 . ILE A 1 108 ? 47.74409 43.69612  5.29123    1.000 61.10585  ? 66  ILE A CD1 1 
ATOM   100  N  N   . ASN A 1 109 ? 48.39350 39.00423  2.38809    1.000 65.84388  ? 67  ASN A N   1 
ATOM   101  C  CA  . ASN A 1 109 ? 49.15764 38.12126  1.50510    1.000 68.43868  ? 67  ASN A CA  1 
ATOM   102  C  C   . ASN A 1 109 ? 48.26278 37.36564  0.52521    1.000 65.60060  ? 67  ASN A C   1 
ATOM   103  O  O   . ASN A 1 109 ? 48.60228 37.23469  -0.65636   1.000 68.05287  ? 67  ASN A O   1 
ATOM   104  C  CB  . ASN A 1 109 ? 49.98373 37.14178  2.33375    1.000 75.47419  ? 67  ASN A CB  1 
ATOM   105  C  CG  . ASN A 1 109 ? 51.18282 37.80554  2.98111    1.000 75.88087  ? 67  ASN A CG  1 
ATOM   106  O  OD1 . ASN A 1 109 ? 51.59319 38.90400  2.58620    1.000 69.21800  ? 67  ASN A OD1 1 
ATOM   107  N  ND2 . ASN A 1 109 ? 51.74626 37.14838  3.98901    1.000 71.37440  ? 67  ASN A ND2 1 
ATOM   108  N  N   . ASP A 1 110 ? 47.11865 36.85824  0.98989    1.000 63.07098  ? 68  ASP A N   1 
ATOM   109  C  CA  . ASP A 1 110 ? 46.20801 36.16682  0.08121    1.000 62.65842  ? 68  ASP A CA  1 
ATOM   110  C  C   . ASP A 1 110 ? 45.63272 37.11313  -0.96534   1.000 61.97527  ? 68  ASP A C   1 
ATOM   111  O  O   . ASP A 1 110 ? 45.72561 36.84541  -2.17158   1.000 55.62946  ? 68  ASP A O   1 
ATOM   112  C  CB  . ASP A 1 110 ? 45.07248 35.48933  0.85706    1.000 74.00059  ? 68  ASP A CB  1 
ATOM   113  C  CG  . ASP A 1 110 ? 45.52571 34.24908  1.62462    1.000 88.88417  ? 68  ASP A CG  1 
ATOM   114  O  OD1 . ASP A 1 110 ? 46.75137 33.97790  1.68170    1.000 92.90408  ? 68  ASP A OD1 1 
ATOM   115  O  OD2 . ASP A 1 110 ? 44.64013 33.53936  2.16372    1.000 85.13768  ? 68  ASP A OD2 1 
ATOM   116  N  N   . ASN A 1 111 ? 45.04095 38.23185  -0.52485   1.000 58.97763  ? 69  ASN A N   1 
ATOM   117  C  CA  . ASN A 1 111 ? 44.38960 39.13341  -1.47194   1.000 59.68743  ? 69  ASN A CA  1 
ATOM   118  C  C   . ASN A 1 111 ? 45.39653 39.72604  -2.45125   1.000 53.98177  ? 69  ASN A C   1 
ATOM   119  O  O   . ASN A 1 111 ? 45.05420 39.96068  -3.61625   1.000 55.96381  ? 69  ASN A O   1 
ATOM   120  C  CB  . ASN A 1 111 ? 43.62882 40.25520  -0.74599   1.000 52.88677  ? 69  ASN A CB  1 
ATOM   121  C  CG  . ASN A 1 111 ? 42.52773 39.73764  0.19795    1.000 60.61052  ? 69  ASN A CG  1 
ATOM   122  O  OD1 . ASN A 1 111 ? 41.91533 40.52655  0.91628    1.000 66.73185  ? 69  ASN A OD1 1 
ATOM   123  N  ND2 . ASN A 1 111 ? 42.28993 38.42020  0.20997    1.000 65.89507  ? 69  ASN A ND2 1 
ATOM   124  N  N   . VAL A 1 112 ? 46.64127 39.96008  -2.01067   1.000 49.51433  ? 70  VAL A N   1 
ATOM   125  C  CA  . VAL A 1 112 ? 47.66260 40.49255  -2.91526   1.000 48.93371  ? 70  VAL A CA  1 
ATOM   126  C  C   . VAL A 1 112 ? 47.95381 39.49708  -4.03528   1.000 48.83508  ? 70  VAL A C   1 
ATOM   127  O  O   . VAL A 1 112 ? 47.97372 39.85828  -5.21831   1.000 48.12837  ? 70  VAL A O   1 
ATOM   128  C  CB  . VAL A 1 112 ? 48.93743 40.87029  -2.13802   1.000 56.39452  ? 70  VAL A CB  1 
ATOM   129  C  CG1 . VAL A 1 112 ? 50.08171 41.15042  -3.10624   1.000 50.07107  ? 70  VAL A CG1 1 
ATOM   130  C  CG2 . VAL A 1 112 ? 48.67566 42.10553  -1.25558   1.000 52.59992  ? 70  VAL A CG2 1 
ATOM   131  N  N   . SER A 1 113 ? 48.17553 38.22510  -3.68030   1.000 57.34181  ? 71  SER A N   1 
ATOM   132  C  CA  . SER A 1 113 ? 48.35200 37.18219  -4.69358   1.000 56.59605  ? 71  SER A CA  1 
ATOM   133  C  C   . SER A 1 113 ? 47.16290 37.13186  -5.64671   1.000 53.29330  ? 71  SER A C   1 
ATOM   134  O  O   . SER A 1 113 ? 47.33986 37.01921  -6.86680   1.000 50.85693  ? 71  SER A O   1 
ATOM   135  C  CB  . SER A 1 113 ? 48.54812 35.82456  -4.01829   1.000 47.01130  ? 71  SER A CB  1 
ATOM   136  O  OG  . SER A 1 113 ? 49.61412 35.88857  -3.08615   1.000 69.54593  ? 71  SER A OG  1 
ATOM   137  N  N   . THR A 1 114 ? 45.94145 37.22382  -5.10443   1.000 40.15934  ? 72  THR A N   1 
ATOM   138  C  CA  . THR A 1 114 ? 44.75259 37.29983  -5.94816   1.000 49.04767  ? 72  THR A CA  1 
ATOM   139  C  C   . THR A 1 114 ? 44.83268 38.48423  -6.90788   1.000 50.34365  ? 72  THR A C   1 
ATOM   140  O  O   . THR A 1 114 ? 44.60435 38.33073  -8.11316   1.000 46.34545  ? 72  THR A O   1 
ATOM   141  C  CB  . THR A 1 114 ? 43.49044 37.40122  -5.08388   1.000 55.63745  ? 72  THR A CB  1 
ATOM   142  O  OG1 . THR A 1 114 ? 43.41233 36.28481  -4.19314   1.000 58.70729  ? 72  THR A OG1 1 
ATOM   143  C  CG2 . THR A 1 114 ? 42.24848 37.42467  -5.94929   1.000 54.95807  ? 72  THR A CG2 1 
ATOM   144  N  N   . ILE A 1 115 ? 45.18155 39.67247  -6.39030   1.000 51.21554  ? 73  ILE A N   1 
ATOM   145  C  CA  . ILE A 1 115 ? 45.26912 40.88077  -7.21832   1.000 51.56157  ? 73  ILE A CA  1 
ATOM   146  C  C   . ILE A 1 115 ? 46.31289 40.72103  -8.32419   1.000 48.26182  ? 73  ILE A C   1 
ATOM   147  O  O   . ILE A 1 115 ? 46.10280 41.17629  -9.45651   1.000 48.60188  ? 73  ILE A O   1 
ATOM   148  C  CB  . ILE A 1 115 ? 45.54989 42.11058  -6.33163   1.000 53.91843  ? 73  ILE A CB  1 
ATOM   149  C  CG1 . ILE A 1 115 ? 44.30039 42.46135  -5.51796   1.000 50.91556  ? 73  ILE A CG1 1 
ATOM   150  C  CG2 . ILE A 1 115 ? 46.01432 43.31041  -7.16802   1.000 44.72919  ? 73  ILE A CG2 1 
ATOM   151  C  CD1 . ILE A 1 115 ? 44.51482 43.57446  -4.53636   1.000 46.31241  ? 73  ILE A CD1 1 
ATOM   152  N  N   . LEU A 1 116 ? 47.45620 40.08575  -8.01677   1.000 51.31925  ? 74  LEU A N   1 
ATOM   153  C  CA  . LEU A 1 116 ? 48.49252 39.86706  -9.03200   1.000 53.17574  ? 74  LEU A CA  1 
ATOM   154  C  C   . LEU A 1 116 ? 48.01781 38.91451  -10.13012  1.000 59.25638  ? 74  LEU A C   1 
ATOM   155  O  O   . LEU A 1 116 ? 48.28970 39.14715  -11.31485  1.000 62.16127  ? 74  LEU A O   1 
ATOM   156  C  CB  . LEU A 1 116 ? 49.78161 39.35757  -8.37580   1.000 49.58710  ? 74  LEU A CB  1 
ATOM   157  C  CG  . LEU A 1 116 ? 50.43855 40.36876  -7.41761   1.000 50.27802  ? 74  LEU A CG  1 
ATOM   158  C  CD1 . LEU A 1 116 ? 51.57366 39.74871  -6.60502   1.000 47.69505  ? 74  LEU A CD1 1 
ATOM   159  C  CD2 . LEU A 1 116 ? 50.92818 41.61339  -8.17737   1.000 41.50140  ? 74  LEU A CD2 1 
ATOM   160  N  N   . ALA A 1 117 ? 47.31671 37.83235  -9.75933   1.000 61.23587  ? 75  ALA A N   1 
ATOM   161  C  CA  . ALA A 1 117 ? 46.69383 36.95587  -10.75656  1.000 54.69076  ? 75  ALA A CA  1 
ATOM   162  C  C   . ALA A 1 117 ? 45.62661 37.68544  -11.58048  1.000 60.72593  ? 75  ALA A C   1 
ATOM   163  O  O   . ALA A 1 117 ? 45.55222 37.51224  -12.80280  1.000 60.97089  ? 75  ALA A O   1 
ATOM   164  C  CB  . ALA A 1 117 ? 46.09888 35.73002  -10.07162  1.000 46.67423  ? 75  ALA A CB  1 
ATOM   165  N  N   . GLY A 1 118 ? 44.77757 38.49113  -10.92714  1.000 62.89578  ? 76  GLY A N   1 
ATOM   166  C  CA  . GLY A 1 118 ? 43.74369 39.23269  -11.64439  1.000 58.94339  ? 76  GLY A CA  1 
ATOM   167  C  C   . GLY A 1 118 ? 44.28864 40.27552  -12.60495  1.000 70.69097  ? 76  GLY A C   1 
ATOM   168  O  O   . GLY A 1 118 ? 43.61400 40.64606  -13.57522  1.000 65.51833  ? 76  GLY A O   1 
ATOM   169  N  N   . GLY A 1 119 ? 45.48954 40.79750  -12.32519  1.000 67.69025  ? 77  GLY A N   1 
ATOM   170  C  CA  . GLY A 1 119 ? 46.16184 41.65394  -13.28831  1.000 66.87860  ? 77  GLY A CA  1 
ATOM   171  C  C   . GLY A 1 119 ? 46.49550 40.92929  -14.58152  1.000 78.34338  ? 77  GLY A C   1 
ATOM   172  O  O   . GLY A 1 119 ? 46.29548 41.46770  -15.67540  1.000 81.57981  ? 77  GLY A O   1 
ATOM   173  N  N   . SER A 1 120 ? 47.01082 39.69615  -14.47728  1.000 67.41635  ? 78  SER A N   1 
ATOM   174  C  CA  . SER A 1 120 ? 47.24144 38.88024  -15.66587  1.000 67.48418  ? 78  SER A CA  1 
ATOM   175  C  C   . SER A 1 120 ? 45.93936 38.41705  -16.32175  1.000 76.11264  ? 78  SER A C   1 
ATOM   176  O  O   . SER A 1 120 ? 45.99024 37.85362  -17.42212  1.000 77.97121  ? 78  SER A O   1 
ATOM   177  C  CB  . SER A 1 120 ? 48.13283 37.68610  -15.31800  1.000 60.04707  ? 78  SER A CB  1 
ATOM   178  O  OG  . SER A 1 120 ? 47.39238 36.47680  -15.24418  1.000 65.77230  ? 78  SER A OG  1 
ATOM   179  N  N   . GLY A 1 121 ? 44.78767 38.63457  -15.67003  1.000 69.53809  ? 79  GLY A N   1 
ATOM   180  C  CA  . GLY A 1 121 ? 43.47223 38.29843  -16.18785  1.000 65.57682  ? 79  GLY A CA  1 
ATOM   181  C  C   . GLY A 1 121 ? 42.78166 37.13142  -15.50326  1.000 69.17977  ? 79  GLY A C   1 
ATOM   182  O  O   . GLY A 1 121 ? 41.59548 36.89166  -15.77218  1.000 71.22817  ? 79  GLY A O   1 
ATOM   183  N  N   . THR A 1 122 ? 43.47633 36.40302  -14.62978  1.000 73.84990  ? 80  THR A N   1 
ATOM   184  C  CA  . THR A 1 122 ? 42.90647 35.22234  -13.98644  1.000 63.84373  ? 80  THR A CA  1 
ATOM   185  C  C   . THR A 1 122 ? 41.91622 35.62137  -12.89020  1.000 60.72666  ? 80  THR A C   1 
ATOM   186  O  O   . THR A 1 122 ? 42.17239 36.54749  -12.10981  1.000 56.14811  ? 80  THR A O   1 
ATOM   187  C  CB  . THR A 1 122 ? 44.02588 34.32666  -13.44018  1.000 55.88663  ? 80  THR A CB  1 
ATOM   188  O  OG1 . THR A 1 122 ? 44.29924 33.28885  -14.39822  1.000 51.48306  ? 80  THR A OG1 1 
ATOM   189  C  CG2 . THR A 1 122 ? 43.64402 33.69499  -12.09830  1.000 47.34800  ? 80  THR A CG2 1 
ATOM   190  N  N   . GLY A 1 123 ? 40.75010 34.94386  -12.87069  1.000 46.82143  ? 81  GLY A N   1 
ATOM   191  C  CA  . GLY A 1 123 ? 39.74527 35.16653  -11.84934  1.000 45.18998  ? 81  GLY A CA  1 
ATOM   192  C  C   . GLY A 1 123 ? 40.08199 34.51346  -10.51190  1.000 37.25495  ? 81  GLY A C   1 
ATOM   193  O  O   . GLY A 1 123 ? 41.00087 33.70076  -10.37383  1.000 38.44646  ? 81  GLY A O   1 
ATOM   194  N  N   . SER A 1 124 ? 39.28415 34.87236  -9.50280   1.000 49.55442  ? 82  SER A N   1 
ATOM   195  C  CA  . SER A 1 124 ? 39.51744 34.44535  -8.12822   1.000 52.35797  ? 82  SER A CA  1 
ATOM   196  C  C   . SER A 1 124 ? 38.49347 33.44762  -7.59606   1.000 56.62264  ? 82  SER A C   1 
ATOM   197  O  O   . SER A 1 124 ? 38.82334 32.67433  -6.68588   1.000 57.55644  ? 82  SER A O   1 
ATOM   198  C  CB  . SER A 1 124 ? 39.52813 35.67656  -7.20539   1.000 49.36497  ? 82  SER A CB  1 
ATOM   199  O  OG  . SER A 1 124 ? 38.71062 36.73526  -7.73806   1.000 47.61667  ? 82  SER A OG  1 
ATOM   200  N  N   . VAL A 1 125 ? 37.28041 33.43211  -8.14648   1.000 49.09002  ? 83  VAL A N   1 
ATOM   201  C  CA  . VAL A 1 125 ? 36.18508 32.59969  -7.65086   1.000 53.98807  ? 83  VAL A CA  1 
ATOM   202  C  C   . VAL A 1 125 ? 35.56286 31.79536  -8.79433   1.000 38.52284  ? 83  VAL A C   1 
ATOM   203  O  O   . VAL A 1 125 ? 35.21473 32.35464  -9.84251   1.000 34.91434  ? 83  VAL A O   1 
ATOM   204  C  CB  . VAL A 1 125 ? 35.12580 33.46793  -6.94450   1.000 48.79908  ? 83  VAL A CB  1 
ATOM   205  C  CG1 . VAL A 1 125 ? 34.63885 34.60292  -7.87466   1.000 40.81644  ? 83  VAL A CG1 1 
ATOM   206  C  CG2 . VAL A 1 125 ? 33.96626 32.58438  -6.45566   1.000 48.51002  ? 83  VAL A CG2 1 
ATOM   207  N  N   . THR A 1 126 ? 35.38764 30.48906  -8.58332   1.000 37.93323  ? 84  THR A N   1 
ATOM   208  C  CA  . THR A 1 126 ? 34.77199 29.69342  -9.62998   1.000 26.61535  ? 84  THR A CA  1 
ATOM   209  C  C   . THR A 1 126 ? 33.27823 30.03770  -9.75875   1.000 29.69267  ? 84  THR A C   1 
ATOM   210  O  O   . THR A 1 126 ? 32.60899 30.41555  -8.79243   1.000 27.67628  ? 84  THR A O   1 
ATOM   211  C  CB  . THR A 1 126 ? 34.97295 28.19178  -9.37064   1.000 38.20240  ? 84  THR A CB  1 
ATOM   212  O  OG1 . THR A 1 126 ? 34.20563 27.78101  -8.24335   1.000 31.99989  ? 84  THR A OG1 1 
ATOM   213  C  CG2 . THR A 1 126 ? 36.41883 27.86738  -9.09095   1.000 44.77234  ? 84  THR A CG2 1 
ATOM   214  N  N   . LEU A 1 127 ? 32.77643 29.94804  -10.99038  1.000 22.68255  ? 85  LEU A N   1 
ATOM   215  C  CA  . LEU A 1 127 ? 31.34736 30.03816  -11.26412  1.000 24.72392  ? 85  LEU A CA  1 
ATOM   216  C  C   . LEU A 1 127 ? 30.59091 28.92337  -10.55471  1.000 22.29954  ? 85  LEU A C   1 
ATOM   217  O  O   . LEU A 1 127 ? 30.92607 27.74315  -10.71225  1.000 25.08503  ? 85  LEU A O   1 
ATOM   218  C  CB  . LEU A 1 127 ? 31.11987 29.93444  -12.76517  1.000 24.39224  ? 85  LEU A CB  1 
ATOM   219  C  CG  . LEU A 1 127 ? 31.89540 30.91162  -13.63305  1.000 20.69676  ? 85  LEU A CG  1 
ATOM   220  C  CD1 . LEU A 1 127 ? 31.61372 30.60543  -15.11696  1.000 19.87747  ? 85  LEU A CD1 1 
ATOM   221  C  CD2 . LEU A 1 127 ? 31.48348 32.35114  -13.25981  1.000 20.15842  ? 85  LEU A CD2 1 
ATOM   222  N  N   . ALA A 1 128 ? 29.55680 29.29850  -9.78236   1.000 28.05961  ? 86  ALA A N   1 
ATOM   223  C  CA  . ALA A 1 128 ? 28.76920 28.30455  -9.04866   1.000 21.34259  ? 86  ALA A CA  1 
ATOM   224  C  C   . ALA A 1 128 ? 28.02722 27.36495  -9.99410   1.000 26.87709  ? 86  ALA A C   1 
ATOM   225  O  O   . ALA A 1 128 ? 28.01236 26.14427  -9.79259   1.000 20.43100  ? 86  ALA A O   1 
ATOM   226  C  CB  . ALA A 1 128 ? 27.78427 28.98337  -8.10561   1.000 22.65449  ? 86  ALA A CB  1 
ATOM   227  N  N   . GLY A 1 129 ? 27.37531 27.91937  -11.01020  1.000 20.91782  ? 87  GLY A N   1 
ATOM   228  C  CA  . GLY A 1 129 ? 26.63770 27.11310  -11.96582  1.000 29.97796  ? 87  GLY A CA  1 
ATOM   229  C  C   . GLY A 1 129 ? 25.39633 26.41478  -11.44652  1.000 24.89243  ? 87  GLY A C   1 
ATOM   230  O  O   . GLY A 1 129 ? 24.90722 25.49329  -12.10251  1.000 31.13704  ? 87  GLY A O   1 
ATOM   231  N  N   . ASN A 1 130 ? 24.88321 26.80840  -10.28218  1.000 24.74562  ? 88  ASN A N   1 
ATOM   232  C  CA  . ASN A 1 130 ? 23.74941 26.14208  -9.64744   1.000 25.09220  ? 88  ASN A CA  1 
ATOM   233  C  C   . ASN A 1 130 ? 22.39945 26.83126  -9.87745   1.000 28.41763  ? 88  ASN A C   1 
ATOM   234  O  O   . ASN A 1 130 ? 21.37038 26.31441  -9.41944   1.000 28.90070  ? 88  ASN A O   1 
ATOM   235  C  CB  . ASN A 1 130 ? 24.01812 25.99006  -8.13747   1.000 27.86003  ? 88  ASN A CB  1 
ATOM   236  C  CG  . ASN A 1 130 ? 24.28942 27.32796  -7.41916   1.000 45.67221  ? 88  ASN A CG  1 
ATOM   237  O  OD1 . ASN A 1 130 ? 24.32641 28.41621  -8.03345   1.000 39.44488  ? 88  ASN A OD1 1 
ATOM   238  N  ND2 . ASN A 1 130 ? 24.47839 27.24234  -6.09148   1.000 52.23122  ? 88  ASN A ND2 1 
ATOM   239  N  N   . SER A 1 131 ? 22.36171 27.96884  -10.57097  1.000 25.41533  ? 89  SER A N   1 
ATOM   240  C  CA  . SER A 1 131 ? 21.09133 28.64656  -10.77352  1.000 26.63656  ? 89  SER A CA  1 
ATOM   241  C  C   . SER A 1 131 ? 20.36426 28.07138  -11.99057  1.000 27.16662  ? 89  SER A C   1 
ATOM   242  O  O   . SER A 1 131 ? 20.96608 27.46064  -12.88091  1.000 22.62518  ? 89  SER A O   1 
ATOM   243  C  CB  . SER A 1 131 ? 21.29899 30.16147  -10.92480  1.000 28.00828  ? 89  SER A CB  1 
ATOM   244  O  OG  . SER A 1 131 ? 21.93461 30.50257  -12.14674  1.000 26.85339  ? 89  SER A OG  1 
ATOM   245  N  N   . SER A 1 132 ? 19.04404 28.26373  -12.00771  1.000 23.84333  ? 90  SER A N   1 
ATOM   246  C  CA  . SER A 1 132 ? 18.17532 27.81875  -13.08449  1.000 22.18705  ? 90  SER A CA  1 
ATOM   247  C  C   . SER A 1 132 ? 18.14284 28.86200  -14.18493  1.000 23.96419  ? 90  SER A C   1 
ATOM   248  O  O   . SER A 1 132 ? 18.45661 30.03102  -13.96082  1.000 23.54746  ? 90  SER A O   1 
ATOM   249  C  CB  . SER A 1 132 ? 16.75787 27.59257  -12.56293  1.000 22.49878  ? 90  SER A CB  1 
ATOM   250  O  OG  . SER A 1 132 ? 16.75967 26.61044  -11.54232  1.000 30.56358  ? 90  SER A OG  1 
ATOM   251  N  N   . LEU A 1 133 ? 17.75852 28.43186  -15.38630  1.000 20.14301  ? 91  LEU A N   1 
ATOM   252  C  CA  . LEU A 1 133 ? 17.68888 29.36701  -16.50559  1.000 22.09482  ? 91  LEU A CA  1 
ATOM   253  C  C   . LEU A 1 133 ? 16.70176 30.48905  -16.19775  1.000 31.47320  ? 91  LEU A C   1 
ATOM   254  O  O   . LEU A 1 133 ? 15.64275 30.24398  -15.60292  1.000 22.55368  ? 91  LEU A O   1 
ATOM   255  C  CB  . LEU A 1 133 ? 17.28489 28.65653  -17.79793  1.000 20.27644  ? 91  LEU A CB  1 
ATOM   256  C  CG  . LEU A 1 133 ? 18.31501 27.67242  -18.37583  1.000 26.15647  ? 91  LEU A CG  1 
ATOM   257  C  CD1 . LEU A 1 133 ? 17.79421 27.09279  -19.66192  1.000 20.98182  ? 91  LEU A CD1 1 
ATOM   258  C  CD2 . LEU A 1 133 ? 19.68686 28.34123  -18.62074  1.000 23.82961  ? 91  LEU A CD2 1 
ATOM   259  N  N   . CYS A 1 134 ? 17.08050 31.73125  -16.58610  1.000 23.66927  ? 92  CYS A N   1 
ATOM   260  C  CA  . CYS A 1 134 ? 16.21996 32.90523  -16.42030  1.000 24.93994  ? 92  CYS A CA  1 
ATOM   261  C  C   . CYS A 1 134 ? 14.87429 32.71838  -17.11917  1.000 22.22326  ? 92  CYS A C   1 
ATOM   262  O  O   . CYS A 1 134 ? 14.82423 32.20987  -18.24589  1.000 24.25331  ? 92  CYS A O   1 
ATOM   263  C  CB  . CYS A 1 134 ? 16.86674 34.17097  -17.00826  1.000 20.11722  ? 92  CYS A CB  1 
ATOM   264  S  SG  . CYS A 1 134 ? 18.42739 34.61961  -16.15752  1.000 37.74975  ? 92  CYS A SG  1 
ATOM   265  N  N   . PRO A 1 135 ? 13.78098 33.18431  -16.51203  1.000 32.10680  ? 93  PRO A N   1 
ATOM   266  C  CA  . PRO A 1 135 ? 12.52721 33.39168  -17.26275  1.000 25.75346  ? 93  PRO A CA  1 
ATOM   267  C  C   . PRO A 1 135 ? 12.73312 34.42050  -18.36843  1.000 27.83058  ? 93  PRO A C   1 
ATOM   268  O  O   . PRO A 1 135 ? 13.31401 35.48639  -18.14887  1.000 29.87730  ? 93  PRO A O   1 
ATOM   269  C  CB  . PRO A 1 135 ? 11.56081 33.91767  -16.19501  1.000 32.33358  ? 93  PRO A CB  1 
ATOM   270  C  CG  . PRO A 1 135 ? 12.19018 33.56877  -14.87439  1.000 39.13908  ? 93  PRO A CG  1 
ATOM   271  C  CD  . PRO A 1 135 ? 13.67155 33.63163  -15.11344  1.000 32.11244  ? 93  PRO A CD  1 
ATOM   272  N  N   . ILE A 1 136 ? 12.30349 34.07958  -19.57955  1.000 19.22963  ? 94  ILE A N   1 
ATOM   273  C  CA  . ILE A 1 136 ? 12.47481 34.96924  -20.72134  1.000 21.89738  ? 94  ILE A CA  1 
ATOM   274  C  C   . ILE A 1 136 ? 11.21777 34.92672  -21.56522  1.000 24.53243  ? 94  ILE A C   1 
ATOM   275  O  O   . ILE A 1 136 ? 10.48041 33.93372  -21.57892  1.000 26.31561  ? 94  ILE A O   1 
ATOM   276  C  CB  . ILE A 1 136 ? 13.68226 34.58833  -21.61661  1.000 25.01478  ? 94  ILE A CB  1 
ATOM   277  C  CG1 . ILE A 1 136 ? 13.41664 33.22627  -22.29183  1.000 24.18464  ? 94  ILE A CG1 1 
ATOM   278  C  CG2 . ILE A 1 136 ? 15.01708 34.60608  -20.83211  1.000 18.76696  ? 94  ILE A CG2 1 
ATOM   279  C  CD1 . ILE A 1 136 ? 14.54922 32.75443  -23.20662  1.000 20.03457  ? 94  ILE A CD1 1 
ATOM   280  N  N   . SER A 1 137 ? 11.01116 35.99173  -22.33315  1.000 21.83488  ? 95  SER A N   1 
ATOM   281  C  CA  . SER A 1 137 ? 9.90292  36.02586  -23.27794  1.000 20.90411  ? 95  SER A CA  1 
ATOM   282  C  C   . SER A 1 137 ? 10.38351 36.10865  -24.70668  1.000 20.62660  ? 95  SER A C   1 
ATOM   283  O  O   . SER A 1 137 ? 9.60489  35.79606  -25.60757  1.000 17.41901  ? 95  SER A O   1 
ATOM   284  C  CB  . SER A 1 137 ? 8.97165  37.21771  -22.98685  1.000 23.15743  ? 95  SER A CB  1 
ATOM   285  O  OG  . SER A 1 137 ? 9.74407  38.39975  -23.12557  1.000 30.64589  ? 95  SER A OG  1 
ATOM   286  N  N   . GLY A 1 138 ? 11.65481 36.43830  -24.93865  1.000 16.66449  ? 96  GLY A N   1 
ATOM   287  C  CA  . GLY A 1 138 ? 12.13540 36.56737  -26.30324  1.000 13.89182  ? 96  GLY A CA  1 
ATOM   288  C  C   . GLY A 1 138 ? 13.62581 36.82080  -26.32323  1.000 13.81791  ? 96  GLY A C   1 
ATOM   289  O  O   . GLY A 1 138 ? 14.29376 36.78141  -25.28376  1.000 16.15503  ? 96  GLY A O   1 
ATOM   290  N  N   . TRP A 1 139 ? 14.14371 37.12998  -27.51603  1.000 16.45217  ? 97  TRP A N   1 
ATOM   291  C  CA  . TRP A 1 139 ? 15.59198 37.23420  -27.73226  1.000 15.30495  ? 97  TRP A CA  1 
ATOM   292  C  C   . TRP A 1 139 ? 15.96816 38.63085  -28.22225  1.000 21.39667  ? 97  TRP A C   1 
ATOM   293  O  O   . TRP A 1 139 ? 15.41429 39.12545  -29.21316  1.000 21.40473  ? 97  TRP A O   1 
ATOM   294  C  CB  . TRP A 1 139 ? 16.04855 36.14117  -28.72210  1.000 11.38723  ? 97  TRP A CB  1 
ATOM   295  C  CG  . TRP A 1 139 ? 15.60592 34.82008  -28.19933  1.000 13.95012  ? 97  TRP A CG  1 
ATOM   296  C  CD1 . TRP A 1 139 ? 14.38075 34.22048  -28.39791  1.000 19.71865  ? 97  TRP A CD1 1 
ATOM   297  C  CD2 . TRP A 1 139 ? 16.34592 33.94263  -27.33201  1.000 18.73522  ? 97  TRP A CD2 1 
ATOM   298  N  NE1 . TRP A 1 139 ? 14.31788 33.01981  -27.70380  1.000 18.84772  ? 97  TRP A NE1 1 
ATOM   299  C  CE2 . TRP A 1 139 ? 15.51454 32.82859  -27.04986  1.000 18.94184  ? 97  TRP A CE2 1 
ATOM   300  C  CE3 . TRP A 1 139 ? 17.63567 33.98786  -26.77105  1.000 17.13275  ? 97  TRP A CE3 1 
ATOM   301  C  CZ2 . TRP A 1 139 ? 15.93977 31.76542  -26.24093  1.000 21.53087  ? 97  TRP A CZ2 1 
ATOM   302  C  CZ3 . TRP A 1 139 ? 18.04943 32.94930  -25.95408  1.000 21.90584  ? 97  TRP A CZ3 1 
ATOM   303  C  CH2 . TRP A 1 139 ? 17.21140 31.84037  -25.70368  1.000 19.86404  ? 97  TRP A CH2 1 
ATOM   304  N  N   . ALA A 1 140 ? 16.91469 39.26785  -27.53077  1.000 20.61250  ? 98  ALA A N   1 
ATOM   305  C  CA  . ALA A 1 140 ? 17.42064 40.58206  -27.91246  1.000 17.80791  ? 98  ALA A CA  1 
ATOM   306  C  C   . ALA A 1 140 ? 18.77817 40.43428  -28.59934  1.000 20.67383  ? 98  ALA A C   1 
ATOM   307  O  O   . ALA A 1 140 ? 19.63136 39.66754  -28.14527  1.000 20.14024  ? 98  ALA A O   1 
ATOM   308  C  CB  . ALA A 1 140 ? 17.53836 41.50682  -26.69338  1.000 16.73309  ? 98  ALA A CB  1 
ATOM   309  N  N   . ILE A 1 141 ? 18.96335 41.12984  -29.71849  1.000 19.19794  ? 99  ILE A N   1 
ATOM   310  C  CA  . ILE A 1 141 ? 20.20915 40.97051  -30.44696  1.000 21.74467  ? 99  ILE A CA  1 
ATOM   311  C  C   . ILE A 1 141 ? 21.37072 41.49688  -29.60655  1.000 22.80895  ? 99  ILE A C   1 
ATOM   312  O  O   . ILE A 1 141 ? 21.29379 42.56880  -28.98851  1.000 17.26863  ? 99  ILE A O   1 
ATOM   313  C  CB  . ILE A 1 141 ? 20.12994 41.63278  -31.82940  1.000 19.63816  ? 99  ILE A CB  1 
ATOM   314  C  CG1 . ILE A 1 141 ? 21.30279 41.11422  -32.67589  1.000 15.55292  ? 99  ILE A CG1 1 
ATOM   315  C  CG2 . ILE A 1 141 ? 20.04773 43.19650  -31.70558  1.000 16.49448  ? 99  ILE A CG2 1 
ATOM   316  C  CD1 . ILE A 1 141 ? 21.02474 41.10568  -34.14807  1.000 17.20288  ? 99  ILE A CD1 1 
ATOM   317  N  N   . TYR A 1 142 ? 22.43778 40.70016  -29.53721  1.000 23.25164  ? 100 TYR A N   1 
ATOM   318  C  CA  . TYR A 1 142 ? 23.63891 40.96571  -28.75653  1.000 18.42494  ? 100 TYR A CA  1 
ATOM   319  C  C   . TYR A 1 142 ? 24.81315 41.39188  -29.62185  1.000 19.79394  ? 100 TYR A C   1 
ATOM   320  O  O   . TYR A 1 142 ? 25.46508 42.39316  -29.30818  1.000 18.82049  ? 100 TYR A O   1 
ATOM   321  C  CB  . TYR A 1 142 ? 24.00759 39.70269  -27.95727  1.000 15.33202  ? 100 TYR A CB  1 
ATOM   322  C  CG  . TYR A 1 142 ? 25.15608 39.82555  -26.99610  1.000 19.03265  ? 100 TYR A CG  1 
ATOM   323  C  CD1 . TYR A 1 142 ? 25.08964 40.71207  -25.91457  1.000 20.25225  ? 100 TYR A CD1 1 
ATOM   324  C  CD2 . TYR A 1 142 ? 26.31061 39.02583  -27.14303  1.000 19.67398  ? 100 TYR A CD2 1 
ATOM   325  C  CE1 . TYR A 1 142 ? 26.14896 40.81826  -25.01215  1.000 23.54200  ? 100 TYR A CE1 1 
ATOM   326  C  CE2 . TYR A 1 142 ? 27.37093 39.12882  -26.24707  1.000 25.18980  ? 100 TYR A CE2 1 
ATOM   327  C  CZ  . TYR A 1 142 ? 27.27001 40.02936  -25.17603  1.000 25.47866  ? 100 TYR A CZ  1 
ATOM   328  O  OH  . TYR A 1 142 ? 28.29306 40.13461  -24.26882  1.000 29.22970  ? 100 TYR A OH  1 
ATOM   329  N  N   . SER A 1 143 ? 25.10095 40.66730  -30.70882  1.000 17.71070  ? 101 SER A N   1 
ATOM   330  C  CA  . SER A 1 143 ? 26.24328 41.01807  -31.54556  1.000 13.76379  ? 101 SER A CA  1 
ATOM   331  C  C   . SER A 1 143 ? 25.94716 40.70164  -32.99289  1.000 17.29217  ? 101 SER A C   1 
ATOM   332  O  O   . SER A 1 143 ? 25.12332 39.85339  -33.30755  1.000 20.18209  ? 101 SER A O   1 
ATOM   333  C  CB  . SER A 1 143 ? 27.51906 40.25488  -31.14047  1.000 19.36843  ? 101 SER A CB  1 
ATOM   334  O  OG  . SER A 1 143 ? 27.49807 38.90733  -31.62318  1.000 20.32360  ? 101 SER A OG  1 
ATOM   335  N  N   . LYS A 1 144 ? 26.68629 41.35877  -33.86615  1.000 17.45851  ? 102 LYS A N   1 
ATOM   336  C  CA  . LYS A 1 144 ? 26.84129 40.98496  -35.26304  1.000 17.70304  ? 102 LYS A CA  1 
ATOM   337  C  C   . LYS A 1 144 ? 28.21907 41.49002  -35.67022  1.000 21.62140  ? 102 LYS A C   1 
ATOM   338  O  O   . LYS A 1 144 ? 28.55633 42.62579  -35.33655  1.000 16.97147  ? 102 LYS A O   1 
ATOM   339  C  CB  . LYS A 1 144 ? 25.76582 41.61707  -36.13115  1.000 16.33787  ? 102 LYS A CB  1 
ATOM   340  C  CG  . LYS A 1 144 ? 25.88520 41.30046  -37.59848  1.000 15.79681  ? 102 LYS A CG  1 
ATOM   341  C  CD  . LYS A 1 144 ? 24.80773 42.05889  -38.35970  1.000 18.93938  ? 102 LYS A CD  1 
ATOM   342  C  CE  . LYS A 1 144 ? 24.41005 41.37360  -39.64219  1.000 21.49827  ? 102 LYS A CE  1 
ATOM   343  N  NZ  . LYS A 1 144 ? 25.55684 41.07449  -40.52115  1.000 25.99113  ? 102 LYS A NZ  1 
ATOM   344  N  N   . ASP A 1 145 ? 29.01490 40.67006  -36.36817  1.000 22.16829  ? 103 ASP A N   1 
ATOM   345  C  CA  . ASP A 1 145 ? 30.38593 41.07002  -36.65543  1.000 13.73830  ? 103 ASP A CA  1 
ATOM   346  C  C   . ASP A 1 145 ? 30.61597 41.47126  -38.10254  1.000 19.38930  ? 103 ASP A C   1 
ATOM   347  O  O   . ASP A 1 145 ? 31.66412 42.06927  -38.39351  1.000 16.61492  ? 103 ASP A O   1 
ATOM   348  C  CB  . ASP A 1 145 ? 31.38283 39.94452  -36.28068  1.000 17.91590  ? 103 ASP A CB  1 
ATOM   349  C  CG  . ASP A 1 145 ? 31.13097 38.61955  -37.05376  1.000 28.08355  ? 103 ASP A CG  1 
ATOM   350  O  OD1 . ASP A 1 145 ? 31.54911 37.57001  -36.50635  1.000 28.10770  ? 103 ASP A OD1 1 
ATOM   351  O  OD2 . ASP A 1 145 ? 30.50478 38.61113  -38.15805  1.000 15.98538  ? 103 ASP A OD2 1 
ATOM   352  N  N   . ASN A 1 146 ? 29.69682 41.14882  -39.02736  1.000 12.66048  ? 104 ASN A N   1 
ATOM   353  C  CA  . ASN A 1 146 ? 29.87807 41.60158  -40.40509  1.000 18.66239  ? 104 ASN A CA  1 
ATOM   354  C  C   . ASN A 1 146 ? 31.23395 41.14421  -40.94531  1.000 19.14490  ? 104 ASN A C   1 
ATOM   355  O  O   . ASN A 1 146 ? 31.89336 41.87847  -41.68124  1.000 20.38367  ? 104 ASN A O   1 
ATOM   356  C  CB  . ASN A 1 146 ? 29.77087 43.14783  -40.49344  1.000 18.54660  ? 104 ASN A CB  1 
ATOM   357  C  CG  . ASN A 1 146 ? 28.33608 43.67917  -40.30562  1.000 16.82290  ? 104 ASN A CG  1 
ATOM   358  O  OD1 . ASN A 1 146 ? 27.40843 43.18843  -40.92501  1.000 20.54274  ? 104 ASN A OD1 1 
ATOM   359  N  ND2 . ASN A 1 146 ? 28.17359 44.72121  -39.48793  1.000 14.88588  ? 104 ASN A ND2 1 
ATOM   360  N  N   . GLY A 1 147 ? 31.68690 39.95061  -40.53147  1.000 16.56006  ? 105 GLY A N   1 
ATOM   361  C  CA  . GLY A 1 147 ? 33.04778 39.54064  -40.83518  1.000 14.04857  ? 105 GLY A CA  1 
ATOM   362  C  C   . GLY A 1 147 ? 33.33748 39.50966  -42.31979  1.000 19.21716  ? 105 GLY A C   1 
ATOM   363  O  O   . GLY A 1 147 ? 34.37690 39.99046  -42.76946  1.000 16.23820  ? 105 GLY A O   1 
ATOM   364  N  N   . ILE A 1 148 ? 32.41596 38.96626  -43.10492  1.000 16.90732  ? 106 ILE A N   1 
ATOM   365  C  CA  . ILE A 1 148 ? 32.70889 38.72981  -44.51215  1.000 17.40999  ? 106 ILE A CA  1 
ATOM   366  C  C   . ILE A 1 148 ? 32.59553 40.02825  -45.30621  1.000 17.74562  ? 106 ILE A C   1 
ATOM   367  O  O   . ILE A 1 148 ? 33.40518 40.29121  -46.20290  1.000 19.25033  ? 106 ILE A O   1 
ATOM   368  C  CB  . ILE A 1 148 ? 31.77931 37.63363  -45.05683  1.000 17.05614  ? 106 ILE A CB  1 
ATOM   369  C  CG1 . ILE A 1 148 ? 32.08290 36.29667  -44.38458  1.000 17.14007  ? 106 ILE A CG1 1 
ATOM   370  C  CG2 . ILE A 1 148 ? 31.95429 37.49854  -46.54559  1.000 15.93232  ? 106 ILE A CG2 1 
ATOM   371  C  CD1 . ILE A 1 148 ? 31.08491 35.19526  -44.82131  1.000 20.33421  ? 106 ILE A CD1 1 
ATOM   372  N  N   . ARG A 1 149 ? 31.61556 40.87769  -44.97953  1.000 15.05501  ? 107 ARG A N   1 
ATOM   373  C  CA  . ARG A 1 149 ? 31.57140 42.21042  -45.59028  1.000 14.99738  ? 107 ARG A CA  1 
ATOM   374  C  C   . ARG A 1 149 ? 32.88242 42.97481  -45.33107  1.000 15.96650  ? 107 ARG A C   1 
ATOM   375  O  O   . ARG A 1 149 ? 33.46048 43.57283  -46.24404  1.000 18.37748  ? 107 ARG A O   1 
ATOM   376  C  CB  . ARG A 1 149 ? 30.39413 43.00667  -45.03624  1.000 14.69503  ? 107 ARG A CB  1 
ATOM   377  C  CG  . ARG A 1 149 ? 29.01722 42.51707  -45.43910  1.000 15.73832  ? 107 ARG A CG  1 
ATOM   378  C  CD  . ARG A 1 149 ? 27.94388 43.26498  -44.58771  1.000 22.95150  ? 107 ARG A CD  1 
ATOM   379  N  NE  . ARG A 1 149 ? 27.95299 44.72094  -44.74345  1.000 15.14405  ? 107 ARG A NE  1 
ATOM   380  C  CZ  . ARG A 1 149 ? 27.35596 45.37991  -45.73641  1.000 24.85342  ? 107 ARG A CZ  1 
ATOM   381  N  NH1 . ARG A 1 149 ? 26.79847 44.74543  -46.75694  1.000 15.81300  ? 107 ARG A NH1 1 
ATOM   382  N  NH2 . ARG A 1 149 ? 27.31337 46.71202  -45.70196  1.000 19.87284  ? 107 ARG A NH2 1 
ATOM   383  N  N   . ILE A 1 150 ? 33.37045 42.94965  -44.07993  1.000 15.69021  ? 108 ILE A N   1 
ATOM   384  C  CA  . ILE A 1 150 ? 34.59897 43.65899  -43.73856  1.000 15.93008  ? 108 ILE A CA  1 
ATOM   385  C  C   . ILE A 1 150 ? 35.81644 43.03369  -44.43513  1.000 21.03633  ? 108 ILE A C   1 
ATOM   386  O  O   . ILE A 1 150 ? 36.71421 43.74496  -44.89592  1.000 19.61623  ? 108 ILE A O   1 
ATOM   387  C  CB  . ILE A 1 150 ? 34.76220 43.71475  -42.20407  1.000 20.04836  ? 108 ILE A CB  1 
ATOM   388  C  CG1 . ILE A 1 150 ? 33.67260 44.62221  -41.60042  1.000 17.16137  ? 108 ILE A CG1 1 
ATOM   389  C  CG2 . ILE A 1 150 ? 36.20642 44.19350  -41.82999  1.000 16.37734  ? 108 ILE A CG2 1 
ATOM   390  C  CD1 . ILE A 1 150 ? 33.53668 44.53866  -40.07505  1.000 17.72034  ? 108 ILE A CD1 1 
ATOM   391  N  N   . GLY A 1 151 ? 35.86563 41.70593  -44.52471  1.000 15.49438  ? 109 GLY A N   1 
ATOM   392  C  CA  . GLY A 1 151 ? 36.97669 40.97109  -45.12265  1.000 13.55484  ? 109 GLY A CA  1 
ATOM   393  C  C   . GLY A 1 151 ? 37.03825 41.06555  -46.62521  1.000 18.96322  ? 109 GLY A C   1 
ATOM   394  O  O   . GLY A 1 151 ? 38.03541 40.63030  -47.21175  1.000 22.37351  ? 109 GLY A O   1 
ATOM   395  N  N   . SER A 1 152 ? 36.00947 41.64621  -47.25466  1.000 14.73178  ? 110 SER A N   1 
ATOM   396  C  CA  . SER A 1 152 ? 36.08772 42.00538  -48.66985  1.000 16.01600  ? 110 SER A CA  1 
ATOM   397  C  C   . SER A 1 152 ? 37.27038 42.92215  -48.92951  1.000 22.54353  ? 110 SER A C   1 
ATOM   398  O  O   . SER A 1 152 ? 37.85847 42.89725  -50.01390  1.000 23.82797  ? 110 SER A O   1 
ATOM   399  C  CB  . SER A 1 152 ? 34.77496 42.68551  -49.09095  1.000 21.28209  ? 110 SER A CB  1 
ATOM   400  O  OG  . SER A 1 152 ? 34.75139 43.06250  -50.45923  1.000 17.31218  ? 110 SER A OG  1 
ATOM   401  N  N   . LYS A 1 153 ? 37.63221 43.72836  -47.94616  1.000 18.99008  ? 111 LYS A N   1 
ATOM   402  C  CA  . LYS A 1 153 ? 38.75847 44.64358  -48.03343  1.000 24.99670  ? 111 LYS A CA  1 
ATOM   403  C  C   . LYS A 1 153 ? 39.74982 44.41406  -46.91045  1.000 18.11646  ? 111 LYS A C   1 
ATOM   404  O  O   . LYS A 1 153 ? 40.95715 44.39023  -47.13970  1.000 17.74544  ? 111 LYS A O   1 
ATOM   405  C  CB  . LYS A 1 153 ? 38.25614 46.09563  -47.98881  1.000 25.11002  ? 111 LYS A CB  1 
ATOM   406  C  CG  . LYS A 1 153 ? 39.36534 47.12160  -47.72870  1.000 30.38128  ? 111 LYS A CG  1 
ATOM   407  C  CD  . LYS A 1 153 ? 39.76849 47.72370  -49.02014  1.000 26.99681  ? 111 LYS A CD  1 
ATOM   408  C  CE  . LYS A 1 153 ? 40.34913 49.12154  -48.85383  1.000 24.54250  ? 111 LYS A CE  1 
ATOM   409  N  NZ  . LYS A 1 153 ? 41.45601 49.28424  -47.84492  1.000 27.99400  ? 111 LYS A NZ  1 
ATOM   410  N  N   . GLY A 1 154 ? 39.26053 44.22099  -45.69900  1.000 15.51962  ? 112 GLY A N   1 
ATOM   411  C  CA  . GLY A 1 154 ? 40.12662 44.05381  -44.55796  1.000 14.70786  ? 112 GLY A CA  1 
ATOM   412  C  C   . GLY A 1 154 ? 40.83586 42.72443  -44.60797  1.000 13.98928  ? 112 GLY A C   1 
ATOM   413  O  O   . GLY A 1 154 ? 40.64744 41.92044  -45.51353  1.000 21.33398  ? 112 GLY A O   1 
ATOM   414  N  N   . ASP A 1 155 ? 41.69700 42.50461  -43.61419  1.000 19.93059  ? 113 ASP A N   1 
ATOM   415  C  CA  . ASP A 1 155 ? 42.52250 41.29533  -43.51517  1.000 13.92077  ? 113 ASP A CA  1 
ATOM   416  C  C   . ASP A 1 155 ? 41.81356 40.42497  -42.49461  1.000 15.27764  ? 113 ASP A C   1 
ATOM   417  O  O   . ASP A 1 155 ? 41.99675 40.57911  -41.28975  1.000 18.64433  ? 113 ASP A O   1 
ATOM   418  C  CB  . ASP A 1 155 ? 43.96983 41.60202  -43.10308  1.000 14.63223  ? 113 ASP A CB  1 
ATOM   419  C  CG  . ASP A 1 155 ? 44.74802 42.34997  -44.16574  1.000 17.74326  ? 113 ASP A CG  1 
ATOM   420  O  OD1 . ASP A 1 155 ? 44.40439 42.27719  -45.37876  1.000 17.71809  ? 113 ASP A OD1 1 
ATOM   421  O  OD2 . ASP A 1 155 ? 45.76979 42.95346  -43.77691  1.000 21.44343  ? 113 ASP A OD2 1 
ATOM   422  N  N   . VAL A 1 156 ? 40.94025 39.54476  -42.98864  1.000 11.70502  ? 114 VAL A N   1 
ATOM   423  C  CA  . VAL A 1 156 ? 40.00901 38.81432  -42.14354  1.000 15.56315  ? 114 VAL A CA  1 
ATOM   424  C  C   . VAL A 1 156 ? 40.11162 37.32644  -42.45854  1.000 11.97942  ? 114 VAL A C   1 
ATOM   425  O  O   . VAL A 1 156 ? 40.13617 36.93818  -43.63420  1.000 14.81938  ? 114 VAL A O   1 
ATOM   426  C  CB  . VAL A 1 156 ? 38.57220 39.33387  -42.34305  1.000 16.08565  ? 114 VAL A CB  1 
ATOM   427  C  CG1 . VAL A 1 156 ? 37.52599 38.45882  -41.56340  1.000 14.49548  ? 114 VAL A CG1 1 
ATOM   428  C  CG2 . VAL A 1 156 ? 38.51834 40.82743  -41.96629  1.000 15.46617  ? 114 VAL A CG2 1 
ATOM   429  N  N   . PHE A 1 157 ? 40.19377 36.50947  -41.41658  1.000 11.02799  ? 115 PHE A N   1 
ATOM   430  C  CA  . PHE A 1 157 ? 40.25967 35.05818  -41.58592  1.000 14.69107  ? 115 PHE A CA  1 
ATOM   431  C  C   . PHE A 1 157 ? 39.01219 34.51303  -42.26833  1.000 19.09719  ? 115 PHE A C   1 
ATOM   432  O  O   . PHE A 1 157 ? 37.89265 34.90537  -41.94460  1.000 16.22016  ? 115 PHE A O   1 
ATOM   433  C  CB  . PHE A 1 157 ? 40.39105 34.37264  -40.22864  1.000 14.04165  ? 115 PHE A CB  1 
ATOM   434  C  CG  . PHE A 1 157 ? 41.74281 34.50794  -39.59633  1.000 18.86458  ? 115 PHE A CG  1 
ATOM   435  C  CD1 . PHE A 1 157 ? 42.86066 33.90635  -40.18024  1.000 16.08646  ? 115 PHE A CD1 1 
ATOM   436  C  CD2 . PHE A 1 157 ? 41.89373 35.18252  -38.39993  1.000 17.25508  ? 115 PHE A CD2 1 
ATOM   437  C  CE1 . PHE A 1 157 ? 44.09277 33.99370  -39.60431  1.000 15.32951  ? 115 PHE A CE1 1 
ATOM   438  C  CE2 . PHE A 1 157 ? 43.13514 35.26772  -37.81028  1.000 17.84963  ? 115 PHE A CE2 1 
ATOM   439  C  CZ  . PHE A 1 157 ? 44.23884 34.68097  -38.42555  1.000 17.43389  ? 115 PHE A CZ  1 
ATOM   440  N  N   . VAL A 1 158 ? 39.21140 33.57149  -43.18661  1.000 19.81176  ? 116 VAL A N   1 
ATOM   441  C  CA  . VAL A 1 158 ? 38.15689 32.61542  -43.51176  1.000 19.58901  ? 116 VAL A CA  1 
ATOM   442  C  C   . VAL A 1 158 ? 37.94762 31.71694  -42.30626  1.000 26.50906  ? 116 VAL A C   1 
ATOM   443  O  O   . VAL A 1 158 ? 38.91117 31.13761  -41.77655  1.000 15.91710  ? 116 VAL A O   1 
ATOM   444  C  CB  . VAL A 1 158 ? 38.53802 31.78326  -44.74273  1.000 24.67315  ? 116 VAL A CB  1 
ATOM   445  C  CG1 . VAL A 1 158 ? 37.59961 30.63099  -44.84444  1.000 23.92697  ? 116 VAL A CG1 1 
ATOM   446  C  CG2 . VAL A 1 158 ? 38.41453 32.61839  -45.97943  1.000 26.68369  ? 116 VAL A CG2 1 
ATOM   447  N  N   . ILE A 1 159 ? 36.70223 31.63277  -41.82120  1.000 18.71282  ? 117 ILE A N   1 
ATOM   448  C  CA  . ILE A 1 159 ? 36.45186 30.92851  -40.57103  1.000 13.69586  ? 117 ILE A CA  1 
ATOM   449  C  C   . ILE A 1 159 ? 35.22661 30.01844  -40.67372  1.000 20.89117  ? 117 ILE A C   1 
ATOM   450  O  O   . ILE A 1 159 ? 34.38351 30.14647  -41.56695  1.000 17.52514  ? 117 ILE A O   1 
ATOM   451  C  CB  . ILE A 1 159 ? 36.25904 31.90192  -39.41351  1.000 15.26091  ? 117 ILE A CB  1 
ATOM   452  C  CG1 . ILE A 1 159 ? 34.92279 32.64204  -39.60753  1.000 22.57994  ? 117 ILE A CG1 1 
ATOM   453  C  CG2 . ILE A 1 159 ? 37.33797 32.92934  -39.40090  1.000 19.49147  ? 117 ILE A CG2 1 
ATOM   454  C  CD1 . ILE A 1 159 ? 34.33082 33.03723  -38.34014  1.000 24.32562  ? 117 ILE A CD1 1 
ATOM   455  N  N   . ARG A 1 160 ? 35.12526 29.11256  -39.70438  1.000 17.87459  ? 118 ARG A N   1 
ATOM   456  C  CA  . ARG A 1 160 ? 33.93047 28.31717  -39.47338  1.000 19.45898  ? 118 ARG A CA  1 
ATOM   457  C  C   . ARG A 1 160 ? 33.68653 28.27753  -37.97510  1.000 18.49639  ? 118 ARG A C   1 
ATOM   458  O  O   . ARG A 1 160 ? 34.57374 28.58382  -37.16174  1.000 17.65957  ? 118 ARG A O   1 
ATOM   459  C  CB  . ARG A 1 160 ? 34.07867 26.88739  -40.02612  1.000 19.65557  ? 118 ARG A CB  1 
ATOM   460  C  CG  . ARG A 1 160 ? 34.02387 26.78493  -41.53444  1.000 22.37733  ? 118 ARG A CG  1 
ATOM   461  C  CD  . ARG A 1 160 ? 32.68772 27.27786  -42.11519  1.000 24.29053  ? 118 ARG A CD  1 
ATOM   462  N  NE  . ARG A 1 160 ? 31.52204 26.78061  -41.38846  1.000 20.55763  ? 118 ARG A NE  1 
ATOM   463  C  CZ  . ARG A 1 160 ? 30.97314 25.58489  -41.56084  1.000 27.83338  ? 118 ARG A CZ  1 
ATOM   464  N  NH1 . ARG A 1 160 ? 31.45513 24.72058  -42.43995  1.000 25.49190  ? 118 ARG A NH1 1 
ATOM   465  N  NH2 . ARG A 1 160 ? 29.94334 25.23264  -40.80075  1.000 17.35588  ? 118 ARG A NH2 1 
ATOM   466  N  N   . GLU A 1 161 ? 32.45802 27.92254  -37.62525  1.000 17.79616  ? 119 GLU A N   1 
ATOM   467  C  CA  . GLU A 1 161 ? 31.97136 27.75902  -36.25629  1.000 17.85172  ? 119 GLU A CA  1 
ATOM   468  C  C   . GLU A 1 161 ? 32.38892 28.86810  -35.27928  1.000 21.48554  ? 119 GLU A C   1 
ATOM   469  O  O   . GLU A 1 161 ? 33.05335 28.60210  -34.27619  1.000 17.21686  ? 119 GLU A O   1 
ATOM   470  C  CB  . GLU A 1 161 ? 32.32427 26.38670  -35.70381  1.000 21.96612  ? 119 GLU A CB  1 
ATOM   471  C  CG  . GLU A 1 161 ? 33.77958 26.08123  -35.60309  1.000 21.79047  ? 119 GLU A CG  1 
ATOM   472  C  CD  . GLU A 1 161 ? 33.97329 24.63926  -35.23028  1.000 29.00324  ? 119 GLU A CD  1 
ATOM   473  O  OE1 . GLU A 1 161 ? 33.52794 23.74411  -36.01900  1.000 23.07464  ? 119 GLU A OE1 1 
ATOM   474  O  OE2 . GLU A 1 161 ? 34.55727 24.43720  -34.13864  1.000 24.98497  ? 119 GLU A OE2 1 
ATOM   475  N  N   . PRO A 1 162 ? 31.93421 30.11109  -35.51401  1.000 15.36796  ? 120 PRO A N   1 
ATOM   476  C  CA  . PRO A 1 162 ? 32.22497 31.22625  -34.59776  1.000 17.63927  ? 120 PRO A CA  1 
ATOM   477  C  C   . PRO A 1 162 ? 31.38035 31.16806  -33.32565  1.000 23.21536  ? 120 PRO A C   1 
ATOM   478  O  O   . PRO A 1 162 ? 30.41662 31.92375  -33.12727  1.000 22.66558  ? 120 PRO A O   1 
ATOM   479  C  CB  . PRO A 1 162 ? 31.87915 32.45718  -35.44455  1.000 18.77573  ? 120 PRO A CB  1 
ATOM   480  C  CG  . PRO A 1 162 ? 30.63503 31.96506  -36.26554  1.000 19.30828  ? 120 PRO A CG  1 
ATOM   481  C  CD  . PRO A 1 162 ? 31.00565 30.49116  -36.58895  1.000 19.24702  ? 120 PRO A CD  1 
ATOM   482  N  N   . PHE A 1 163 ? 31.74242 30.26924  -32.42529  1.000 17.83698  ? 121 PHE A N   1 
ATOM   483  C  CA  . PHE A 1 163 ? 30.97612 30.09660  -31.20369  1.000 16.37511  ? 121 PHE A CA  1 
ATOM   484  C  C   . PHE A 1 163 ? 31.44610 31.03993  -30.10059  1.000 21.91472  ? 121 PHE A C   1 
ATOM   485  O  O   . PHE A 1 163 ? 32.62771 31.35924  -29.97406  1.000 18.33385  ? 121 PHE A O   1 
ATOM   486  C  CB  . PHE A 1 163 ? 31.01392 28.63675  -30.72371  1.000 15.36608  ? 121 PHE A CB  1 
ATOM   487  C  CG  . PHE A 1 163 ? 32.34902 28.14251  -30.18410  1.000 16.12130  ? 121 PHE A CG  1 
ATOM   488  C  CD1 . PHE A 1 163 ? 32.64945 28.25570  -28.83605  1.000 14.13313  ? 121 PHE A CD1 1 
ATOM   489  C  CD2 . PHE A 1 163 ? 33.22283 27.42816  -30.99659  1.000 15.12428  ? 121 PHE A CD2 1 
ATOM   490  C  CE1 . PHE A 1 163 ? 33.85429 27.72323  -28.31201  1.000 19.10216  ? 121 PHE A CE1 1 
ATOM   491  C  CE2 . PHE A 1 163 ? 34.40921 26.87854  -30.48881  1.000 16.89453  ? 121 PHE A CE2 1 
ATOM   492  C  CZ  . PHE A 1 163 ? 34.73071 27.04172  -29.13795  1.000 15.42909  ? 121 PHE A CZ  1 
ATOM   493  N  N   . ILE A 1 164 ? 30.50196 31.47316  -29.28404  1.000 18.39653  ? 122 ILE A N   1 
ATOM   494  C  CA  . ILE A 1 164 ? 30.77379 32.42197  -28.21708  1.000 14.35872  ? 122 ILE A CA  1 
ATOM   495  C  C   . ILE A 1 164 ? 30.85245 31.69352  -26.88103  1.000 18.69227  ? 122 ILE A C   1 
ATOM   496  O  O   . ILE A 1 164 ? 30.16984 30.68999  -26.63752  1.000 17.68938  ? 122 ILE A O   1 
ATOM   497  C  CB  . ILE A 1 164 ? 29.69566 33.52990  -28.16662  1.000 14.88533  ? 122 ILE A CB  1 
ATOM   498  C  CG1 . ILE A 1 164 ? 29.69292 34.35398  -29.45266  1.000 13.03410  ? 122 ILE A CG1 1 
ATOM   499  C  CG2 . ILE A 1 164 ? 29.85341 34.41093  -26.91011  1.000 14.19030  ? 122 ILE A CG2 1 
ATOM   500  C  CD1 . ILE A 1 164 ? 28.72193 35.54130  -29.34911  1.000 15.02242  ? 122 ILE A CD1 1 
ATOM   501  N  N   . SER A 1 165 ? 31.71119 32.20961  -26.00747  1.000 15.97376  ? 123 SER A N   1 
ATOM   502  C  CA  . SER A 1 165 ? 31.83741 31.77998  -24.62617  1.000 21.67684  ? 123 SER A CA  1 
ATOM   503  C  C   . SER A 1 165 ? 32.33572 32.98666  -23.85189  1.000 21.59296  ? 123 SER A C   1 
ATOM   504  O  O   . SER A 1 165 ? 33.02208 33.85161  -24.41250  1.000 15.15107  ? 123 SER A O   1 
ATOM   505  C  CB  . SER A 1 165 ? 32.79368 30.58260  -24.47890  1.000 16.30979  ? 123 SER A CB  1 
ATOM   506  O  OG  . SER A 1 165 ? 32.71822 30.04106  -23.16547  1.000 21.20328  ? 123 SER A OG  1 
ATOM   507  N  N   . CYS A 1 166 ? 31.95741 33.05960  -22.57821  1.000 21.97312  ? 124 CYS A N   1 
ATOM   508  C  CA  . CYS A 1 166 ? 32.18678 34.24730  -21.76082  1.000 29.26163  ? 124 CYS A CA  1 
ATOM   509  C  C   . CYS A 1 166 ? 32.95499 33.88500  -20.49792  1.000 25.96643  ? 124 CYS A C   1 
ATOM   510  O  O   . CYS A 1 166 ? 32.73024 32.82198  -19.91083  1.000 31.43606  ? 124 CYS A O   1 
ATOM   511  C  CB  . CYS A 1 166 ? 30.84699 34.89116  -21.35738  1.000 28.77338  ? 124 CYS A CB  1 
ATOM   512  S  SG  . CYS A 1 166 ? 29.75228 35.29903  -22.72321  1.000 30.59739  ? 124 CYS A SG  1 
ATOM   513  N  N   . SER A 1 167 ? 33.84547 34.77693  -20.06565  1.000 35.59439  ? 125 SER A N   1 
ATOM   514  C  CA  . SER A 1 167 ? 34.40580 34.67052  -18.72783  1.000 37.24793  ? 125 SER A CA  1 
ATOM   515  C  C   . SER A 1 167 ? 33.48296 35.41629  -17.75995  1.000 50.32068  ? 125 SER A C   1 
ATOM   516  O  O   . SER A 1 167 ? 32.31259 35.67723  -18.05830  1.000 52.74303  ? 125 SER A O   1 
ATOM   517  C  CB  . SER A 1 167 ? 35.83815 35.20655  -18.71085  1.000 33.59056  ? 125 SER A CB  1 
ATOM   518  O  OG  . SER A 1 167 ? 35.87023 36.56070  -19.10569  1.000 46.72333  ? 125 SER A OG  1 
ATOM   519  N  N   . HIS A 1 168 ? 33.98213 35.76098  -16.58841  1.000 56.17147  ? 126 HIS A N   1 
ATOM   520  C  CA  . HIS A 1 168 ? 33.23680 36.64972  -15.71954  1.000 58.14334  ? 126 HIS A CA  1 
ATOM   521  C  C   . HIS A 1 168 ? 33.51499 38.11143  -16.02612  1.000 52.81732  ? 126 HIS A C   1 
ATOM   522  O  O   . HIS A 1 168 ? 32.90365 38.97342  -15.38298  1.000 58.37642  ? 126 HIS A O   1 
ATOM   523  C  CB  . HIS A 1 168 ? 33.51919 36.34182  -14.24573  1.000 51.38131  ? 126 HIS A CB  1 
ATOM   524  C  CG  . HIS A 1 168 ? 34.97220 36.35617  -13.89726  1.000 60.67716  ? 126 HIS A CG  1 
ATOM   525  N  ND1 . HIS A 1 168 ? 35.92329 35.69309  -14.64480  1.000 63.24871  ? 126 HIS A ND1 1 
ATOM   526  C  CD2 . HIS A 1 168 ? 35.64226 36.96437  -12.89137  1.000 57.50159  ? 126 HIS A CD2 1 
ATOM   527  C  CE1 . HIS A 1 168 ? 37.11408 35.87398  -14.10315  1.000 62.39770  ? 126 HIS A CE1 1 
ATOM   528  N  NE2 . HIS A 1 168 ? 36.97202 36.64629  -13.04004  1.000 70.18160  ? 126 HIS A NE2 1 
ATOM   529  N  N   . LEU A 1 169 ? 34.40567 38.39930  -17.00300  1.000 48.62696  ? 127 LEU A N   1 
ATOM   530  C  CA  . LEU A 1 169 ? 34.74392 39.75874  -17.42826  1.000 41.48056  ? 127 LEU A CA  1 
ATOM   531  C  C   . LEU A 1 169 ? 34.53741 40.07526  -18.90737  1.000 52.01108  ? 127 LEU A C   1 
ATOM   532  O  O   . LEU A 1 169 ? 34.46854 41.26847  -19.24768  1.000 52.80381  ? 127 LEU A O   1 
ATOM   533  C  CB  . LEU A 1 169 ? 36.19372 40.13561  -17.08869  1.000 56.02185  ? 127 LEU A CB  1 
ATOM   534  C  CG  . LEU A 1 169 ? 36.65346 40.17206  -15.63360  1.000 70.29139  ? 127 LEU A CG  1 
ATOM   535  C  CD1 . LEU A 1 169 ? 35.52724 40.70361  -14.70015  1.000 54.89222  ? 127 LEU A CD1 1 
ATOM   536  C  CD2 . LEU A 1 169 ? 37.16621 38.83924  -15.21498  1.000 68.27869  ? 127 LEU A CD2 1 
ATOM   537  N  N   . GLU A 1 170 ? 34.49255 39.08366  -19.79871  1.000 35.33580  ? 128 GLU A N   1 
ATOM   538  C  CA  . GLU A 1 170 ? 34.24165 39.37145  -21.20893  1.000 35.91257  ? 128 GLU A CA  1 
ATOM   539  C  C   . GLU A 1 170 ? 33.67902 38.12193  -21.88501  1.000 30.50774  ? 128 GLU A C   1 
ATOM   540  O  O   . GLU A 1 170 ? 33.72001 37.01668  -21.33564  1.000 28.54960  ? 128 GLU A O   1 
ATOM   541  C  CB  . GLU A 1 170 ? 35.51224 39.89381  -21.93009  1.000 30.14299  ? 128 GLU A CB  1 
ATOM   542  C  CG  . GLU A 1 170 ? 36.23449 38.86580  -22.78921  1.000 40.34235  ? 128 GLU A CG  1 
ATOM   543  C  CD  . GLU A 1 170 ? 37.49185 39.38705  -23.52091  1.000 41.84030  ? 128 GLU A CD  1 
ATOM   544  O  OE1 . GLU A 1 170 ? 38.53643 38.68897  -23.45169  1.000 40.45568  ? 128 GLU A OE1 1 
ATOM   545  O  OE2 . GLU A 1 170 ? 37.41995 40.43905  -24.20565  1.000 40.74165  ? 128 GLU A OE2 1 
ATOM   546  N  N   . CYS A 1 171 ? 33.12924 38.34052  -23.08218  1.000 22.70492  ? 129 CYS A N   1 
ATOM   547  C  CA  . CYS A 1 171 ? 32.58461 37.32915  -23.96975  1.000 22.13204  ? 129 CYS A CA  1 
ATOM   548  C  C   . CYS A 1 171 ? 33.43591 37.32518  -25.23446  1.000 28.81544  ? 129 CYS A C   1 
ATOM   549  O  O   . CYS A 1 171 ? 33.72657 38.39421  -25.79599  1.000 21.77810  ? 129 CYS A O   1 
ATOM   550  C  CB  . CYS A 1 171 ? 31.11655 37.62752  -24.32390  1.000 25.55389  ? 129 CYS A CB  1 
ATOM   551  S  SG  . CYS A 1 171 ? 29.94246 37.39263  -22.96619  1.000 31.71174  ? 129 CYS A SG  1 
ATOM   552  N  N   . ARG A 1 172 ? 33.81839 36.13057  -25.70238  1.000 18.64511  ? 130 ARG A N   1 
ATOM   553  C  CA  . ARG A 1 172 ? 34.65019 36.03254  -26.88427  1.000 16.25087  ? 130 ARG A CA  1 
ATOM   554  C  C   . ARG A 1 172 ? 34.01283 35.13472  -27.93392  1.000 20.38717  ? 130 ARG A C   1 
ATOM   555  O  O   . ARG A 1 172 ? 33.26392 34.19686  -27.61754  1.000 19.39295  ? 130 ARG A O   1 
ATOM   556  C  CB  . ARG A 1 172 ? 36.08928 35.51255  -26.50678  1.000 20.75987  ? 130 ARG A CB  1 
ATOM   557  C  CG  . ARG A 1 172 ? 36.77668 36.39062  -25.41804  1.000 15.02516  ? 130 ARG A CG  1 
ATOM   558  C  CD  . ARG A 1 172 ? 38.16341 35.80963  -25.03129  1.000 25.81646  ? 130 ARG A CD  1 
ATOM   559  N  NE  . ARG A 1 172 ? 39.06604 35.84021  -26.17690  1.000 20.98790  ? 130 ARG A NE  1 
ATOM   560  C  CZ  . ARG A 1 172 ? 39.67393 36.93098  -26.61452  1.000 23.23332  ? 130 ARG A CZ  1 
ATOM   561  N  NH1 . ARG A 1 172 ? 39.52332 38.09064  -26.00498  1.000 22.41746  ? 130 ARG A NH1 1 
ATOM   562  N  NH2 . ARG A 1 172 ? 40.39922 36.86582  -27.72427  1.000 19.60045  ? 130 ARG A NH2 1 
ATOM   563  N  N   . THR A 1 173 ? 34.34211 35.42107  -29.19684  1.000 18.85105  ? 131 THR A N   1 
ATOM   564  C  CA  . THR A 1 173 ? 34.03943 34.51977  -30.30107  1.000 18.60451  ? 131 THR A CA  1 
ATOM   565  C  C   . THR A 1 173 ? 35.25813 33.63515  -30.57225  1.000 26.70929  ? 131 THR A C   1 
ATOM   566  O  O   . THR A 1 173 ? 36.32973 34.12551  -30.95970  1.000 14.40311  ? 131 THR A O   1 
ATOM   567  C  CB  . THR A 1 173 ? 33.63333 35.28581  -31.55954  1.000 17.51647  ? 131 THR A CB  1 
ATOM   568  O  OG1 . THR A 1 173 ? 32.34626 35.89552  -31.34621  1.000 18.44367  ? 131 THR A OG1 1 
ATOM   569  C  CG2 . THR A 1 173 ? 33.51717 34.34702  -32.75073  1.000 16.60333  ? 131 THR A CG2 1 
ATOM   570  N  N   . PHE A 1 174 ? 35.09485 32.33805  -30.35173  1.000 17.65466  ? 132 PHE A N   1 
ATOM   571  C  CA  . PHE A 1 174 ? 36.07994 31.35350  -30.76648  1.000 16.30923  ? 132 PHE A CA  1 
ATOM   572  C  C   . PHE A 1 174 ? 35.76018 30.92359  -32.18663  1.000 17.37892  ? 132 PHE A C   1 
ATOM   573  O  O   . PHE A 1 174 ? 34.61835 31.02380  -32.63058  1.000 21.99364  ? 132 PHE A O   1 
ATOM   574  C  CB  . PHE A 1 174 ? 36.04431 30.18181  -29.79624  1.000 17.38494  ? 132 PHE A CB  1 
ATOM   575  C  CG  . PHE A 1 174 ? 36.55139 30.54231  -28.43236  1.000 17.16657  ? 132 PHE A CG  1 
ATOM   576  C  CD1 . PHE A 1 174 ? 35.74426 31.21527  -27.53189  1.000 16.83256  ? 132 PHE A CD1 1 
ATOM   577  C  CD2 . PHE A 1 174 ? 37.86493 30.25448  -28.07374  1.000 16.31779  ? 132 PHE A CD2 1 
ATOM   578  C  CE1 . PHE A 1 174 ? 36.22724 31.58257  -26.27235  1.000 15.01061  ? 132 PHE A CE1 1 
ATOM   579  C  CE2 . PHE A 1 174 ? 38.36481 30.60172  -26.81885  1.000 15.24368  ? 132 PHE A CE2 1 
ATOM   580  C  CZ  . PHE A 1 174 ? 37.55476 31.27587  -25.91704  1.000 11.98829  ? 132 PHE A CZ  1 
ATOM   581  N  N   . PHE A 1 175 ? 36.77083 30.49080  -32.92331  1.000 16.23932  ? 133 PHE A N   1 
ATOM   582  C  CA  . PHE A 1 175 ? 36.48452 30.06411  -34.28446  1.000 14.74090  ? 133 PHE A CA  1 
ATOM   583  C  C   . PHE A 1 175 ? 37.64715 29.24327  -34.78838  1.000 20.86509  ? 133 PHE A C   1 
ATOM   584  O  O   . PHE A 1 175 ? 38.74249 29.28337  -34.22678  1.000 17.07694  ? 133 PHE A O   1 
ATOM   585  C  CB  . PHE A 1 175 ? 36.22314 31.24243  -35.22013  1.000 16.60243  ? 133 PHE A CB  1 
ATOM   586  C  CG  . PHE A 1 175 ? 37.35578 32.24409  -35.26735  1.000 16.25253  ? 133 PHE A CG  1 
ATOM   587  C  CD1 . PHE A 1 175 ? 38.42346 32.09188  -36.15867  1.000 15.54168  ? 133 PHE A CD1 1 
ATOM   588  C  CD2 . PHE A 1 175 ? 37.34427 33.36060  -34.42285  1.000 18.29364  ? 133 PHE A CD2 1 
ATOM   589  C  CE1 . PHE A 1 175 ? 39.47270 33.04924  -36.19400  1.000 20.73808  ? 133 PHE A CE1 1 
ATOM   590  C  CE2 . PHE A 1 175 ? 38.38371 34.30817  -34.44061  1.000 18.27497  ? 133 PHE A CE2 1 
ATOM   591  C  CZ  . PHE A 1 175 ? 39.43560 34.17408  -35.32167  1.000 12.29953  ? 133 PHE A CZ  1 
ATOM   592  N  N   . LEU A 1 176 ? 37.38371 28.48728  -35.85502  1.000 19.80350  ? 134 LEU A N   1 
ATOM   593  C  CA  . LEU A 1 176 ? 38.38828 27.67710  -36.51808  1.000 17.47342  ? 134 LEU A CA  1 
ATOM   594  C  C   . LEU A 1 176 ? 38.74479 28.36783  -37.80616  1.000 16.26472  ? 134 LEU A C   1 
ATOM   595  O  O   . LEU A 1 176 ? 37.86642 28.88843  -38.49602  1.000 17.34273  ? 134 LEU A O   1 
ATOM   596  C  CB  . LEU A 1 176 ? 37.87814 26.26773  -36.85956  1.000 18.07649  ? 134 LEU A CB  1 
ATOM   597  C  CG  . LEU A 1 176 ? 37.54362 25.36919  -35.67965  1.000 20.66510  ? 134 LEU A CG  1 
ATOM   598  C  CD1 . LEU A 1 176 ? 37.06654 23.97090  -36.13219  1.000 22.57887  ? 134 LEU A CD1 1 
ATOM   599  C  CD2 . LEU A 1 176 ? 38.77227 25.23768  -34.81007  1.000 16.21411  ? 134 LEU A CD2 1 
ATOM   600  N  N   . THR A 1 177 ? 40.02788 28.39720  -38.13528  1.000 17.02097  ? 135 THR A N   1 
ATOM   601  C  CA  . THR A 1 177 ? 40.38711 28.91711  -39.44041  1.000 13.50708  ? 135 THR A CA  1 
ATOM   602  C  C   . THR A 1 177 ? 41.45129 28.00690  -40.01841  1.000 19.52471  ? 135 THR A C   1 
ATOM   603  O  O   . THR A 1 177 ? 42.23229 27.43069  -39.27933  1.000 21.69289  ? 135 THR A O   1 
ATOM   604  C  CB  . THR A 1 177 ? 40.89200 30.37737  -39.39473  1.000 21.53687  ? 135 THR A CB  1 
ATOM   605  O  OG1 . THR A 1 177 ? 41.47554 30.71762  -40.67157  1.000 26.95744  ? 135 THR A OG1 1 
ATOM   606  C  CG2 . THR A 1 177 ? 41.91353 30.64083  -38.23069  1.000 20.60596  ? 135 THR A CG2 1 
ATOM   607  N  N   . GLN A 1 178 ? 41.49801 27.92374  -41.33889  1.000 21.99110  ? 136 GLN A N   1 
ATOM   608  C  CA  . GLN A 1 178 ? 42.58330 27.27881  -42.06431  1.000 23.48803  ? 136 GLN A CA  1 
ATOM   609  C  C   . GLN A 1 178 ? 43.85812 28.11736  -42.11630  1.000 24.78190  ? 136 GLN A C   1 
ATOM   610  O  O   . GLN A 1 178 ? 44.78629 27.73743  -42.84671  1.000 24.71741  ? 136 GLN A O   1 
ATOM   611  C  CB  . GLN A 1 178 ? 42.14411 26.98389  -43.49966  1.000 24.14809  ? 136 GLN A CB  1 
ATOM   612  C  CG  . GLN A 1 178 ? 41.05419 25.91156  -43.62565  1.000 27.95640  ? 136 GLN A CG  1 
ATOM   613  C  CD  . GLN A 1 178 ? 41.61071 24.48885  -43.57218  1.000 39.75885  ? 136 GLN A CD  1 
ATOM   614  O  OE1 . GLN A 1 178 ? 42.84254 24.28469  -43.58676  1.000 28.76478  ? 136 GLN A OE1 1 
ATOM   615  N  NE2 . GLN A 1 178 ? 40.70204 23.49036  -43.53988  1.000 22.30319  ? 136 GLN A NE2 1 
ATOM   616  N  N   . GLY A 1 179 ? 43.92151 29.25231  -41.41983  1.000 20.02061  ? 137 GLY A N   1 
ATOM   617  C  CA  . GLY A 1 179 ? 45.10059 30.08303  -41.53175  1.000 21.71242  ? 137 GLY A CA  1 
ATOM   618  C  C   . GLY A 1 179 ? 45.21079 30.73167  -42.89363  1.000 28.78468  ? 137 GLY A C   1 
ATOM   619  O  O   . GLY A 1 179 ? 46.31115 30.79546  -43.47524  1.000 31.59559  ? 137 GLY A O   1 
ATOM   620  N  N   . ALA A 1 180 ? 44.08830 31.17660  -43.43431  1.000 16.41701  ? 138 ALA A N   1 
ATOM   621  C  CA  . ALA A 1 180 ? 44.01471 31.87855  -44.70674  1.000 17.33021  ? 138 ALA A CA  1 
ATOM   622  C  C   . ALA A 1 180 ? 43.08765 33.06855  -44.52875  1.000 17.57213  ? 138 ALA A C   1 
ATOM   623  O  O   . ALA A 1 180 ? 42.17582 33.03379  -43.69360  1.000 19.93140  ? 138 ALA A O   1 
ATOM   624  C  CB  . ALA A 1 180 ? 43.46289 30.98379  -45.83378  1.000 16.84694  ? 138 ALA A CB  1 
ATOM   625  N  N   . LEU A 1 181 ? 43.29517 34.10534  -45.32901  1.000 18.29758  ? 139 LEU A N   1 
ATOM   626  C  CA  . LEU A 1 181 ? 42.45976 35.30195  -45.25177  1.000 13.80258  ? 139 LEU A CA  1 
ATOM   627  C  C   . LEU A 1 181 ? 41.48138 35.37482  -46.41786  1.000 16.86374  ? 139 LEU A C   1 
ATOM   628  O  O   . LEU A 1 181 ? 41.74591 34.85960  -47.50857  1.000 13.12837  ? 139 LEU A O   1 
ATOM   629  C  CB  . LEU A 1 181 ? 43.30687 36.58296  -45.24752  1.000 12.71469  ? 139 LEU A CB  1 
ATOM   630  C  CG  . LEU A 1 181 ? 44.37419 36.65967  -44.15864  1.000 21.50066  ? 139 LEU A CG  1 
ATOM   631  C  CD1 . LEU A 1 181 ? 44.98654 38.04947  -44.17286  1.000 20.68092  ? 139 LEU A CD1 1 
ATOM   632  C  CD2 . LEU A 1 181 ? 43.79103 36.35417  -42.79937  1.000 16.30318  ? 139 LEU A CD2 1 
ATOM   633  N  N   . LEU A 1 182 ? 40.35282 36.06989  -46.19502  1.000 13.78686  ? 140 LEU A N   1 
ATOM   634  C  CA  . LEU A 1 182 ? 39.41572 36.28881  -47.28677  1.000 13.15496  ? 140 LEU A CA  1 
ATOM   635  C  C   . LEU A 1 182 ? 40.09158 37.03442  -48.42760  1.000 15.73910  ? 140 LEU A C   1 
ATOM   636  O  O   . LEU A 1 182 ? 40.95687 37.89432  -48.21999  1.000 20.17966  ? 140 LEU A O   1 
ATOM   637  C  CB  . LEU A 1 182 ? 38.16716 37.07234  -46.80955  1.000 16.47319  ? 140 LEU A CB  1 
ATOM   638  C  CG  . LEU A 1 182 ? 37.14786 36.32176  -45.95210  1.000 18.72223  ? 140 LEU A CG  1 
ATOM   639  C  CD1 . LEU A 1 182 ? 36.25958 37.27337  -45.17444  1.000 16.90973  ? 140 LEU A CD1 1 
ATOM   640  C  CD2 . LEU A 1 182 ? 36.23895 35.42941  -46.80166  1.000 19.33688  ? 140 LEU A CD2 1 
ATOM   641  N  N   . ASN A 1 183 ? 39.70246 36.68526  -49.64167  1.000 10.63893  ? 141 ASN A N   1 
ATOM   642  C  CA  . ASN A 1 183 ? 40.21142 37.32106  -50.84318  1.000 13.49342  ? 141 ASN A CA  1 
ATOM   643  C  C   . ASN A 1 183 ? 41.69377 37.02396  -51.09399  1.000 22.65216  ? 141 ASN A C   1 
ATOM   644  O  O   . ASN A 1 183 ? 42.37251 37.77520  -51.79331  1.000 21.19909  ? 141 ASN A O   1 
ATOM   645  C  CB  . ASN A 1 183 ? 39.98289 38.83609  -50.80450  1.000 20.64567  ? 141 ASN A CB  1 
ATOM   646  C  CG  . ASN A 1 183 ? 38.97262 39.25977  -51.80343  1.000 18.59158  ? 141 ASN A CG  1 
ATOM   647  O  OD1 . ASN A 1 183 ? 38.71143 38.54022  -52.77122  1.000 24.14368  ? 141 ASN A OD1 1 
ATOM   648  N  ND2 . ASN A 1 183 ? 38.37793 40.42231  -51.58888  1.000 18.60481  ? 141 ASN A ND2 1 
ATOM   649  N  N   . ASP A 1 184 ? 42.18735 35.90886  -50.59487  1.000 16.21961  ? 142 ASP A N   1 
ATOM   650  C  CA  . ASP A 1 184 ? 43.52976 35.45144  -50.90205  1.000 22.40584  ? 142 ASP A CA  1 
ATOM   651  C  C   . ASP A 1 184 ? 43.45462 34.01920  -51.43483  1.000 15.83047  ? 142 ASP A C   1 
ATOM   652  O  O   . ASP A 1 184 ? 42.53709 33.26660  -51.09408  1.000 18.33917  ? 142 ASP A O   1 
ATOM   653  C  CB  . ASP A 1 184 ? 44.39097 35.51066  -49.65894  1.000 16.03830  ? 142 ASP A CB  1 
ATOM   654  C  CG  . ASP A 1 184 ? 45.78410 35.03342  -49.92126  1.000 23.81404  ? 142 ASP A CG  1 
ATOM   655  O  OD1 . ASP A 1 184 ? 46.55114 35.79219  -50.55526  1.000 19.74151  ? 142 ASP A OD1 1 
ATOM   656  O  OD2 . ASP A 1 184 ? 46.07955 33.87264  -49.55257  1.000 18.57700  ? 142 ASP A OD2 1 
ATOM   657  N  N   . LYS A 1 185 ? 44.41820 33.65477  -52.29103  1.000 18.31448  ? 143 LYS A N   1 
ATOM   658  C  CA  . LYS A 1 185 ? 44.41119 32.34217  -52.94301  1.000 19.08929  ? 143 LYS A CA  1 
ATOM   659  C  C   . LYS A 1 185 ? 44.42011 31.19092  -51.93891  1.000 18.29452  ? 143 LYS A C   1 
ATOM   660  O  O   . LYS A 1 185 ? 43.96482 30.09114  -52.25818  1.000 18.16382  ? 143 LYS A O   1 
ATOM   661  C  CB  . LYS A 1 185 ? 45.61174 32.21059  -53.87341  1.000 21.22929  ? 143 LYS A CB  1 
ATOM   662  C  CG  . LYS A 1 185 ? 46.94204 32.16050  -53.11966  1.000 19.54841  ? 143 LYS A CG  1 
ATOM   663  C  CD  . LYS A 1 185 ? 48.08939 31.98428  -54.09080  1.000 31.35119  ? 143 LYS A CD  1 
ATOM   664  C  CE  . LYS A 1 185 ? 49.44749 32.04497  -53.43649  1.000 24.72180  ? 143 LYS A CE  1 
ATOM   665  N  NZ  . LYS A 1 185 ? 50.43618 31.68382  -54.47717  1.000 26.81255  ? 143 LYS A NZ  1 
ATOM   666  N  N   . HIS A 1 186 ? 44.94467 31.40829  -50.73110  1.000 17.17155  ? 144 HIS A N   1 
ATOM   667  C  CA  . HIS A 1 186 ? 44.98107 30.31526  -49.76777  1.000 17.85502  ? 144 HIS A CA  1 
ATOM   668  C  C   . HIS A 1 186 ? 43.61996 29.97452  -49.19306  1.000 24.88148  ? 144 HIS A C   1 
ATOM   669  O  O   . HIS A 1 186 ? 43.50202 28.94728  -48.52233  1.000 20.10543  ? 144 HIS A O   1 
ATOM   670  C  CB  . HIS A 1 186 ? 45.94344 30.64304  -48.63257  1.000 16.65765  ? 144 HIS A CB  1 
ATOM   671  C  CG  . HIS A 1 186 ? 47.37966 30.66859  -49.07744  1.000 22.64390  ? 144 HIS A CG  1 
ATOM   672  N  ND1 . HIS A 1 186 ? 48.03310 31.83605  -49.40641  1.000 18.46478  ? 144 HIS A ND1 1 
ATOM   673  C  CD2 . HIS A 1 186 ? 48.25937 29.66299  -49.32721  1.000 20.76634  ? 144 HIS A CD2 1 
ATOM   674  C  CE1 . HIS A 1 186 ? 49.27583 31.55820  -49.78170  1.000 21.90404  ? 144 HIS A CE1 1 
ATOM   675  N  NE2 . HIS A 1 186 ? 49.43837 30.24542  -49.74524  1.000 21.03129  ? 144 HIS A NE2 1 
ATOM   676  N  N   . SER A 1 187 ? 42.60893 30.81430  -49.40224  1.000 22.25805  ? 145 SER A N   1 
ATOM   677  C  CA  . SER A 1 187 ? 41.26828 30.51199  -48.91771  1.000 15.83101  ? 145 SER A CA  1 
ATOM   678  C  C   . SER A 1 187 ? 40.55040 29.47531  -49.76850  1.000 20.63089  ? 145 SER A C   1 
ATOM   679  O  O   . SER A 1 187 ? 39.39557 29.12636  -49.45163  1.000 19.48447  ? 145 SER A O   1 
ATOM   680  C  CB  . SER A 1 187 ? 40.43566 31.80910  -48.87023  1.000 17.00183  ? 145 SER A CB  1 
ATOM   681  O  OG  . SER A 1 187 ? 40.27629 32.28363  -50.18603  1.000 13.58340  ? 145 SER A OG  1 
ATOM   682  N  N   . ASN A 1 188 ? 41.17022 29.03467  -50.86907  1.000 18.40458  ? 146 ASN A N   1 
ATOM   683  C  CA  . ASN A 1 188 ? 40.61099 27.98667  -51.72358  1.000 25.18583  ? 146 ASN A CA  1 
ATOM   684  C  C   . ASN A 1 188 ? 40.24108 26.75404  -50.90540  1.000 31.99082  ? 146 ASN A C   1 
ATOM   685  O  O   . ASN A 1 188 ? 41.07519 26.20024  -50.19159  1.000 37.06717  ? 146 ASN A O   1 
ATOM   686  C  CB  . ASN A 1 188 ? 41.60499 27.66423  -52.83025  1.000 27.13134  ? 146 ASN A CB  1 
ATOM   687  C  CG  . ASN A 1 188 ? 41.06431 26.71130  -53.86186  1.000 35.14611  ? 146 ASN A CG  1 
ATOM   688  O  OD1 . ASN A 1 188 ? 39.94869 26.20149  -53.75106  1.000 27.46689  ? 146 ASN A OD1 1 
ATOM   689  N  ND2 . ASN A 1 188 ? 41.85126 26.49041  -54.90839  1.000 33.52950  ? 146 ASN A ND2 1 
ATOM   690  N  N   . GLY A 1 189 ? 38.96471 26.35850  -50.98364  1.000 31.35764  ? 147 GLY A N   1 
ATOM   691  C  CA  . GLY A 1 189 ? 38.35265 25.39332  -50.09162  1.000 38.47756  ? 147 GLY A CA  1 
ATOM   692  C  C   . GLY A 1 189 ? 38.50190 23.93241  -50.46349  1.000 42.53360  ? 147 GLY A C   1 
ATOM   693  O  O   . GLY A 1 189 ? 37.84778 23.07673  -49.85534  1.000 48.35712  ? 147 GLY A O   1 
ATOM   694  N  N   . THR A 1 190 ? 39.32724 23.62681  -51.46234  1.000 42.50690  ? 148 THR A N   1 
ATOM   695  C  CA  . THR A 1 190 ? 39.68408 22.24379  -51.75621  1.000 58.51876  ? 148 THR A CA  1 
ATOM   696  C  C   . THR A 1 190 ? 40.38629 21.56836  -50.58020  1.000 56.60938  ? 148 THR A C   1 
ATOM   697  O  O   . THR A 1 190 ? 40.20674 20.36204  -50.36515  1.000 52.09009  ? 148 THR A O   1 
ATOM   698  C  CB  . THR A 1 190 ? 40.54304 22.18970  -53.02056  1.000 64.39842  ? 148 THR A CB  1 
ATOM   699  O  OG1 . THR A 1 190 ? 39.74590 22.62556  -54.13802  1.000 58.31580  ? 148 THR A OG1 1 
ATOM   700  C  CG2 . THR A 1 190 ? 41.06519 20.75802  -53.25923  1.000 71.02177  ? 148 THR A CG2 1 
ATOM   701  N  N   . ILE A 1 191 ? 41.16788 22.32669  -49.80406  1.000 46.60818  ? 149 ILE A N   1 
ATOM   702  C  CA  . ILE A 1 191 ? 41.83614 21.77033  -48.63514  1.000 49.79370  ? 149 ILE A CA  1 
ATOM   703  C  C   . ILE A 1 191 ? 40.83069 21.00702  -47.77100  1.000 47.32872  ? 149 ILE A C   1 
ATOM   704  O  O   . ILE A 1 191 ? 39.68742 21.43884  -47.57988  1.000 48.03643  ? 149 ILE A O   1 
ATOM   705  C  CB  . ILE A 1 191 ? 42.52638 22.90083  -47.84501  1.000 46.74645  ? 149 ILE A CB  1 
ATOM   706  C  CG1 . ILE A 1 191 ? 43.44099 22.34421  -46.73248  1.000 44.88500  ? 149 ILE A CG1 1 
ATOM   707  C  CG2 . ILE A 1 191 ? 41.47888 23.88009  -47.29825  1.000 46.71866  ? 149 ILE A CG2 1 
ATOM   708  C  CD1 . ILE A 1 191 ? 44.30339 21.15726  -47.15131  1.000 39.19964  ? 149 ILE A CD1 1 
ATOM   709  N  N   . LYS A 1 192 ? 41.25217 19.84247  -47.27463  1.000 49.44644  ? 150 LYS A N   1 
ATOM   710  C  CA  . LYS A 1 192 ? 40.38465 19.02556  -46.43633  1.000 38.24701  ? 150 LYS A CA  1 
ATOM   711  C  C   . LYS A 1 192 ? 40.00200 19.80510  -45.18582  1.000 33.65816  ? 150 LYS A C   1 
ATOM   712  O  O   . LYS A 1 192 ? 40.73513 20.68351  -44.71979  1.000 42.02893  ? 150 LYS A O   1 
ATOM   713  C  CB  . LYS A 1 192 ? 41.09818 17.73512  -46.04090  1.000 33.91927  ? 150 LYS A CB  1 
ATOM   714  C  CG  . LYS A 1 192 ? 42.46241 18.02335  -45.39931  1.000 42.44684  ? 150 LYS A CG  1 
ATOM   715  C  CD  . LYS A 1 192 ? 43.45044 16.81110  -45.39040  1.000 46.80538  ? 150 LYS A CD  1 
ATOM   716  C  CE  . LYS A 1 192 ? 44.86107 17.30123  -44.96774  1.000 49.17604  ? 150 LYS A CE  1 
ATOM   717  N  NZ  . LYS A 1 192 ? 45.88110 16.26510  -44.55645  1.000 43.99683  ? 150 LYS A NZ  1 
ATOM   718  N  N   . ASP A 1 193 ? 38.82232 19.49587  -44.66186  1.000 32.15018  ? 151 ASP A N   1 
ATOM   719  C  CA  . ASP A 1 193 ? 38.35241 20.12338  -43.43115  1.000 28.66940  ? 151 ASP A CA  1 
ATOM   720  C  C   . ASP A 1 193 ? 39.31580 19.84778  -42.28487  1.000 23.66752  ? 151 ASP A C   1 
ATOM   721  O  O   . ASP A 1 193 ? 39.63798 20.73202  -41.48362  1.000 26.03553  ? 151 ASP A O   1 
ATOM   722  C  CB  . ASP A 1 193 ? 36.97179 19.57255  -43.11853  1.000 23.01438  ? 151 ASP A CB  1 
ATOM   723  C  CG  . ASP A 1 193 ? 35.88532 20.29714  -43.85563  1.000 49.40635  ? 151 ASP A CG  1 
ATOM   724  O  OD1 . ASP A 1 193 ? 36.05105 21.51389  -44.14021  1.000 48.65865  ? 151 ASP A OD1 1 
ATOM   725  O  OD2 . ASP A 1 193 ? 34.92393 19.59725  -44.25319  1.000 54.51736  ? 151 ASP A OD2 1 
ATOM   726  N  N   . ARG A 1 194 ? 39.78538 18.62121  -42.18866  1.000 19.25070  ? 152 ARG A N   1 
ATOM   727  C  CA  . ARG A 1 194 ? 40.62466 18.23355  -41.07706  1.000 17.71280  ? 152 ARG A CA  1 
ATOM   728  C  C   . ARG A 1 194 ? 42.08971 18.33313  -41.50931  1.000 24.88087  ? 152 ARG A C   1 
ATOM   729  O  O   . ARG A 1 194 ? 42.77018 17.35481  -41.74817  1.000 21.62160  ? 152 ARG A O   1 
ATOM   730  C  CB  . ARG A 1 194 ? 40.21572 16.83743  -40.59050  1.000 18.05884  ? 152 ARG A CB  1 
ATOM   731  C  CG  . ARG A 1 194 ? 38.74986 16.89434  -39.96442  1.000 15.22252  ? 152 ARG A CG  1 
ATOM   732  C  CD  . ARG A 1 194 ? 38.38054 15.57438  -39.36683  1.000 22.93563  ? 152 ARG A CD  1 
ATOM   733  N  NE  . ARG A 1 194 ? 38.42527 14.53677  -40.39398  1.000 21.44799  ? 152 ARG A NE  1 
ATOM   734  C  CZ  . ARG A 1 194 ? 37.46962 14.33904  -41.29525  1.000 22.81007  ? 152 ARG A CZ  1 
ATOM   735  N  NH1 . ARG A 1 194 ? 36.35702 15.05828  -41.29406  1.000 17.54019  ? 152 ARG A NH1 1 
ATOM   736  N  NH2 . ARG A 1 194 ? 37.64000 13.41276  -42.23018  1.000 20.99283  ? 152 ARG A NH2 1 
ATOM   737  N  N   . SER A 1 195 ? 42.55659 19.53788  -41.60335  1.000 20.72271  ? 153 SER A N   1 
ATOM   738  C  CA  . SER A 1 195 ? 43.90864 19.75681  -42.11084  1.000 18.56728  ? 153 SER A CA  1 
ATOM   739  C  C   . SER A 1 195 ? 44.86559 20.11037  -40.98419  1.000 17.16866  ? 153 SER A C   1 
ATOM   740  O  O   . SER A 1 195 ? 44.43991 20.54640  -39.90866  1.000 24.15325  ? 153 SER A O   1 
ATOM   741  C  CB  . SER A 1 195 ? 43.88821 20.86971  -43.16097  1.000 18.58339  ? 153 SER A CB  1 
ATOM   742  O  OG  . SER A 1 195 ? 43.92829 22.10483  -42.53177  1.000 18.26576  ? 153 SER A OG  1 
ATOM   743  N  N   . PRO A 1 196 ? 46.18223 19.90698  -41.17930  1.000 12.71068  ? 154 PRO A N   1 
ATOM   744  C  CA  . PRO A 1 196 ? 47.14599 20.37369  -40.17774  1.000 17.12796  ? 154 PRO A CA  1 
ATOM   745  C  C   . PRO A 1 196 ? 47.20506 21.89973  -40.05390  1.000 20.68854  ? 154 PRO A C   1 
ATOM   746  O  O   . PRO A 1 196 ? 47.75038 22.39640  -39.06188  1.000 18.37403  ? 154 PRO A O   1 
ATOM   747  C  CB  . PRO A 1 196 ? 48.48867 19.80505  -40.67631  1.000 16.98884  ? 154 PRO A CB  1 
ATOM   748  C  CG  . PRO A 1 196 ? 48.32846 19.68001  -42.15431  1.000 18.53839  ? 154 PRO A CG  1 
ATOM   749  C  CD  . PRO A 1 196 ? 46.84496 19.29259  -42.34447  1.000 16.43332  ? 154 PRO A CD  1 
ATOM   750  N  N   . TYR A 1 197 ? 46.65309 22.65524  -40.99250  1.000 20.00798  ? 155 TYR A N   1 
ATOM   751  C  CA  . TYR A 1 197 ? 46.68662 24.11268  -40.84576  1.000 23.32760  ? 155 TYR A CA  1 
ATOM   752  C  C   . TYR A 1 197 ? 45.60259 24.64246  -39.93609  1.000 28.12927  ? 155 TYR A C   1 
ATOM   753  O  O   . TYR A 1 197 ? 45.66656 25.81919  -39.57651  1.000 21.44338  ? 155 TYR A O   1 
ATOM   754  C  CB  . TYR A 1 197 ? 46.53483 24.80500  -42.18738  1.000 16.47597  ? 155 TYR A CB  1 
ATOM   755  C  CG  . TYR A 1 197 ? 47.27662 24.07688  -43.24553  1.000 19.86939  ? 155 TYR A CG  1 
ATOM   756  C  CD1 . TYR A 1 197 ? 48.65842 23.91274  -43.14529  1.000 20.34880  ? 155 TYR A CD1 1 
ATOM   757  C  CD2 . TYR A 1 197 ? 46.63381 23.58510  -44.35576  1.000 16.41238  ? 155 TYR A CD2 1 
ATOM   758  C  CE1 . TYR A 1 197 ? 49.37912 23.20667  -44.11196  1.000 18.07359  ? 155 TYR A CE1 1 
ATOM   759  C  CE2 . TYR A 1 197 ? 47.33553 22.88701  -45.33377  1.000 23.23145  ? 155 TYR A CE2 1 
ATOM   760  C  CZ  . TYR A 1 197 ? 48.71885 22.72180  -45.20187  1.000 24.77661  ? 155 TYR A CZ  1 
ATOM   761  O  OH  . TYR A 1 197 ? 49.44529 22.05548  -46.15177  1.000 21.56793  ? 155 TYR A OH  1 
ATOM   762  N  N   . ARG A 1 198 ? 44.62012 23.81616  -39.55951  1.000 16.20219  ? 156 ARG A N   1 
ATOM   763  C  CA  . ARG A 1 198 ? 43.43178 24.33552  -38.90619  1.000 21.56489  ? 156 ARG A CA  1 
ATOM   764  C  C   . ARG A 1 198 ? 43.76687 24.70174  -37.47175  1.000 21.04515  ? 156 ARG A C   1 
ATOM   765  O  O   . ARG A 1 198 ? 44.34745 23.89234  -36.72583  1.000 13.82886  ? 156 ARG A O   1 
ATOM   766  C  CB  . ARG A 1 198 ? 42.31014 23.29271  -38.92130  1.000 18.96549  ? 156 ARG A CB  1 
ATOM   767  C  CG  . ARG A 1 198 ? 40.92994 23.88441  -38.85626  1.000 23.65473  ? 156 ARG A CG  1 
ATOM   768  C  CD  . ARG A 1 198 ? 40.33415 24.07237  -40.24254  1.000 24.58319  ? 156 ARG A CD  1 
ATOM   769  N  NE  . ARG A 1 198 ? 38.91960 24.45750  -40.16523  1.000 19.90165  ? 156 ARG A NE  1 
ATOM   770  C  CZ  . ARG A 1 198 ? 37.89885 23.61315  -40.26190  1.000 37.94325  ? 156 ARG A CZ  1 
ATOM   771  N  NH1 . ARG A 1 198 ? 38.08898 22.31433  -40.41789  1.000 29.17114  ? 156 ARG A NH1 1 
ATOM   772  N  NH2 . ARG A 1 198 ? 36.65140 24.08038  -40.17661  1.000 30.29262  ? 156 ARG A NH2 1 
ATOM   773  N  N   . THR A 1 199 ? 43.33906 25.88695  -37.05844  1.000 16.33649  ? 157 THR A N   1 
ATOM   774  C  CA  . THR A 1 199 ? 43.62150 26.35428  -35.71115  1.000 17.77386  ? 157 THR A CA  1 
ATOM   775  C  C   . THR A 1 199 ? 42.37807 26.96357  -35.07591  1.000 15.22257  ? 157 THR A C   1 
ATOM   776  O  O   . THR A 1 199 ? 41.53931 27.55524  -35.74598  1.000 20.05464  ? 157 THR A O   1 
ATOM   777  C  CB  . THR A 1 199 ? 44.77586 27.38270  -35.69933  1.000 20.16074  ? 157 THR A CB  1 
ATOM   778  O  OG1 . THR A 1 199 ? 44.39131 28.55936  -36.41836  1.000 19.72793  ? 157 THR A OG1 1 
ATOM   779  C  CG2 . THR A 1 199 ? 46.01060 26.78664  -36.36164  1.000 25.03936  ? 157 THR A CG2 1 
ATOM   780  N  N   . LEU A 1 200 ? 42.29993 26.81636  -33.75983  1.000 13.60212  ? 158 LEU A N   1 
ATOM   781  C  CA  . LEU A 1 200 ? 41.31386 27.45906  -32.92996  1.000 15.03931  ? 158 LEU A CA  1 
ATOM   782  C  C   . LEU A 1 200 ? 41.83821 28.81200  -32.47446  1.000 19.99065  ? 158 LEU A C   1 
ATOM   783  O  O   . LEU A 1 200 ? 42.89219 28.89510  -31.83657  1.000 14.74255  ? 158 LEU A O   1 
ATOM   784  C  CB  . LEU A 1 200 ? 41.01049 26.58602  -31.72155  1.000 10.39706  ? 158 LEU A CB  1 
ATOM   785  C  CG  . LEU A 1 200 ? 39.99995 27.21473  -30.76155  1.000 17.72923  ? 158 LEU A CG  1 
ATOM   786  C  CD1 . LEU A 1 200 ? 38.62566 27.34499  -31.43979  1.000 11.46551  ? 158 LEU A CD1 1 
ATOM   787  C  CD2 . LEU A 1 200 ? 39.96952 26.44739  -29.46795  1.000 14.79122  ? 158 LEU A CD2 1 
ATOM   788  N  N   . MET A 1 201 ? 41.11019 29.86875  -32.79130  1.000 21.62891  ? 159 MET A N   1 
ATOM   789  C  CA  . MET A 1 201 ? 41.48184 31.22014  -32.37664  1.000 18.33017  ? 159 MET A CA  1 
ATOM   790  C  C   . MET A 1 201 ? 40.27218 31.91086  -31.77254  1.000 21.28953  ? 159 MET A C   1 
ATOM   791  O  O   . MET A 1 201 ? 39.16959 31.37506  -31.82250  1.000 19.57640  ? 159 MET A O   1 
ATOM   792  C  CB  . MET A 1 201 ? 42.08307 31.94876  -33.56137  1.000 14.85143  ? 159 MET A CB  1 
ATOM   793  C  CG  . MET A 1 201 ? 43.43055 31.18315  -33.93024  1.000 22.31976  ? 159 MET A CG  1 
ATOM   794  S  SD  . MET A 1 201 ? 44.24213 31.98080  -35.24037  1.000 42.40674  ? 159 MET A SD  1 
ATOM   795  C  CE  . MET A 1 201 ? 44.63545 33.56118  -34.50332  1.000 29.92459  ? 159 MET A CE  1 
ATOM   796  N  N   . SER A 1 202 ? 40.47107 33.09046  -31.18126  1.000 20.46926  ? 160 SER A N   1 
ATOM   797  C  CA  . SER A 1 202 ? 39.33031 33.81509  -30.61142  1.000 21.05853  ? 160 SER A CA  1 
ATOM   798  C  C   . SER A 1 202 ? 39.52716 35.33211  -30.68782  1.000 25.75734  ? 160 SER A C   1 
ATOM   799  O  O   . SER A 1 202 ? 40.65645 35.82864  -30.70787  1.000 17.14536  ? 160 SER A O   1 
ATOM   800  C  CB  . SER A 1 202 ? 39.07429 33.41191  -29.15578  1.000 16.12744  ? 160 SER A CB  1 
ATOM   801  O  OG  . SER A 1 202 ? 40.13593 33.85480  -28.32754  1.000 17.93733  ? 160 SER A OG  1 
ATOM   802  N  N   . CYS A 1 203 ? 38.41221 36.06948  -30.73031  1.000 18.08834  ? 161 CYS A N   1 
ATOM   803  C  CA  . CYS A 1 203 ? 38.50550 37.52408  -30.73438  1.000 17.31182  ? 161 CYS A CA  1 
ATOM   804  C  C   . CYS A 1 203 ? 37.31560 38.07907  -29.96743  1.000 21.46744  ? 161 CYS A C   1 
ATOM   805  O  O   . CYS A 1 203 ? 36.34660 37.34999  -29.70288  1.000 19.78256  ? 161 CYS A O   1 
ATOM   806  C  CB  . CYS A 1 203 ? 38.55841 38.07458  -32.16661  1.000 18.09330  ? 161 CYS A CB  1 
ATOM   807  S  SG  . CYS A 1 203 ? 37.01404 37.76738  -33.09384  1.000 19.07970  ? 161 CYS A SG  1 
ATOM   808  N  N   . PRO A 1 204 ? 37.36307 39.35214  -29.56567  1.000 22.69151  ? 162 PRO A N   1 
ATOM   809  C  CA  . PRO A 1 204 ? 36.20436 39.93118  -28.85443  1.000 18.03096  ? 162 PRO A CA  1 
ATOM   810  C  C   . PRO A 1 204 ? 34.93288 39.79013  -29.67890  1.000 15.69603  ? 162 PRO A C   1 
ATOM   811  O  O   . PRO A 1 204 ? 34.96326 39.86772  -30.90682  1.000 12.63619  ? 162 PRO A O   1 
ATOM   812  C  CB  . PRO A 1 204 ? 36.59120 41.40070  -28.68510  1.000 18.35301  ? 162 PRO A CB  1 
ATOM   813  C  CG  . PRO A 1 204 ? 38.15169 41.37174  -28.68557  1.000 14.73912  ? 162 PRO A CG  1 
ATOM   814  C  CD  . PRO A 1 204 ? 38.49626 40.30142  -29.68575  1.000 13.99460  ? 162 PRO A CD  1 
ATOM   815  N  N   . VAL A 1 205 ? 33.81247 39.53424  -28.99008  1.000 22.17120  ? 163 VAL A N   1 
ATOM   816  C  CA  . VAL A 1 205 ? 32.50952 39.40456  -29.65425  1.000 19.24073  ? 163 VAL A CA  1 
ATOM   817  C  C   . VAL A 1 205 ? 32.19357 40.64213  -30.50438  1.000 18.85975  ? 163 VAL A C   1 
ATOM   818  O  O   . VAL A 1 205 ? 32.36912 41.78413  -30.06301  1.000 14.77960  ? 163 VAL A O   1 
ATOM   819  C  CB  . VAL A 1 205 ? 31.41640 39.13338  -28.60013  1.000 25.80169  ? 163 VAL A CB  1 
ATOM   820  C  CG1 . VAL A 1 205 ? 30.06424 39.50387  -29.11892  1.000 23.33348  ? 163 VAL A CG1 1 
ATOM   821  C  CG2 . VAL A 1 205 ? 31.41782 37.65568  -28.21104  1.000 17.09279  ? 163 VAL A CG2 1 
ATOM   822  N  N   . GLY A 1 206 ? 31.73683 40.40823  -31.75090  1.000 18.74959  ? 164 GLY A N   1 
ATOM   823  C  CA  . GLY A 1 206 ? 31.32948 41.46494  -32.65722  1.000 18.04797  ? 164 GLY A CA  1 
ATOM   824  C  C   . GLY A 1 206 ? 32.42073 42.06305  -33.52148  1.000 21.34063  ? 164 GLY A C   1 
ATOM   825  O  O   . GLY A 1 206 ? 32.12782 42.93303  -34.37159  1.000 22.80599  ? 164 GLY A O   1 
ATOM   826  N  N   . GLU A 1 207 ? 33.67495 41.66830  -33.31909  1.000 18.63572  ? 165 GLU A N   1 
ATOM   827  C  CA  . GLU A 1 207 ? 34.75802 42.17140  -34.13981  1.000 17.84053  ? 165 GLU A CA  1 
ATOM   828  C  C   . GLU A 1 207 ? 35.01357 41.20853  -35.28269  1.000 20.61741  ? 165 GLU A C   1 
ATOM   829  O  O   . GLU A 1 207 ? 34.89198 39.98573  -35.11667  1.000 23.06639  ? 165 GLU A O   1 
ATOM   830  C  CB  . GLU A 1 207 ? 36.00069 42.35827  -33.27972  1.000 17.48458  ? 165 GLU A CB  1 
ATOM   831  C  CG  . GLU A 1 207 ? 35.79029 43.38020  -32.17943  1.000 22.48453  ? 165 GLU A CG  1 
ATOM   832  C  CD  . GLU A 1 207 ? 37.08863 43.72246  -31.44759  1.000 26.39914  ? 165 GLU A CD  1 
ATOM   833  O  OE1 . GLU A 1 207 ? 38.18707 43.42541  -31.97964  1.000 29.27726  ? 165 GLU A OE1 1 
ATOM   834  O  OE2 . GLU A 1 207 ? 37.00697 44.27972  -30.32983  1.000 24.16993  ? 165 GLU A OE2 1 
ATOM   835  N  N   . ALA A 1 208 ? 35.34711 41.75264  -36.44601  1.000 14.81182  ? 166 ALA A N   1 
ATOM   836  C  CA  . ALA A 1 208 ? 35.75019 40.88032  -37.53579  1.000 17.49211  ? 166 ALA A CA  1 
ATOM   837  C  C   . ALA A 1 208 ? 36.98229 40.07479  -37.12489  1.000 18.33412  ? 166 ALA A C   1 
ATOM   838  O  O   . ALA A 1 208 ? 37.90258 40.60779  -36.47618  1.000 17.03936  ? 166 ALA A O   1 
ATOM   839  C  CB  . ALA A 1 208 ? 36.05191 41.65688  -38.81054  1.000 16.27829  ? 166 ALA A CB  1 
ATOM   840  N  N   . PRO A 1 209 ? 37.02193 38.79019  -37.46733  1.000 20.27807  ? 167 PRO A N   1 
ATOM   841  C  CA  . PRO A 1 209 ? 38.11767 37.92734  -37.01051  1.000 17.26559  ? 167 PRO A CA  1 
ATOM   842  C  C   . PRO A 1 209 ? 39.34310 38.11455  -37.86856  1.000 15.03792  ? 167 PRO A C   1 
ATOM   843  O  O   . PRO A 1 209 ? 39.42579 37.59651  -38.98801  1.000 18.00086  ? 167 PRO A O   1 
ATOM   844  C  CB  . PRO A 1 209 ? 37.53458 36.51297  -37.14647  1.000 14.60115  ? 167 PRO A CB  1 
ATOM   845  C  CG  . PRO A 1 209 ? 36.50763 36.62055  -38.24491  1.000 14.84420  ? 167 PRO A CG  1 
ATOM   846  C  CD  . PRO A 1 209 ? 35.91318 38.03086  -38.09576  1.000 15.28885  ? 167 PRO A CD  1 
ATOM   847  N  N   . SER A 1 210 ? 40.31779 38.81934  -37.32196  1.000 16.57759  ? 168 SER A N   1 
ATOM   848  C  CA  A SER A 1 210 ? 41.50067 39.23704  -38.05515  0.500 16.95883  ? 168 SER A CA  1 
ATOM   849  C  CA  B SER A 1 210 ? 41.49950 39.23465  -38.05633  0.500 16.96255  ? 168 SER A CA  1 
ATOM   850  C  C   . SER A 1 210 ? 42.77625 38.74690  -37.37120  1.000 15.12944  ? 168 SER A C   1 
ATOM   851  O  O   . SER A 1 210 ? 42.80575 38.62126  -36.14083  1.000 15.73417  ? 168 SER A O   1 
ATOM   852  C  CB  A SER A 1 210 ? 41.51026 40.76675  -38.13856  0.500 15.13776  ? 168 SER A CB  1 
ATOM   853  C  CB  B SER A 1 210 ? 41.49960 40.76427  -38.14422  0.500 14.94211  ? 168 SER A CB  1 
ATOM   854  O  OG  A SER A 1 210 ? 42.77478 41.24551  -38.50917  0.500 17.54549  ? 168 SER A OG  1 
ATOM   855  O  OG  B SER A 1 210 ? 42.78571 41.26241  -38.38549  0.500 17.54350  ? 168 SER A OG  1 
ATOM   856  N  N   . PRO A 1 211 ? 43.87525 38.50462  -38.12106  1.000 14.89997  ? 169 PRO A N   1 
ATOM   857  C  CA  . PRO A 1 211 ? 45.14563 38.22286  -37.43358  1.000 16.03672  ? 169 PRO A CA  1 
ATOM   858  C  C   . PRO A 1 211 ? 45.55619 39.33908  -36.50996  1.000 24.55151  ? 169 PRO A C   1 
ATOM   859  O  O   . PRO A 1 211 ? 46.39957 39.10093  -35.63733  1.000 14.82171  ? 169 PRO A O   1 
ATOM   860  C  CB  . PRO A 1 211 ? 46.16352 38.07650  -38.57063  1.000 16.10703  ? 169 PRO A CB  1 
ATOM   861  C  CG  . PRO A 1 211 ? 45.56525 38.66925  -39.74448  1.000 16.31877  ? 169 PRO A CG  1 
ATOM   862  C  CD  . PRO A 1 211 ? 44.06345 38.43839  -39.58037  1.000 15.04246  ? 169 PRO A CD  1 
ATOM   863  N  N   . TYR A 1 212 ? 44.97727 40.55384  -36.65505  1.000 13.02554  ? 170 TYR A N   1 
ATOM   864  C  CA  . TYR A 1 212 ? 45.47111 41.66473  -35.83782  1.000 20.40325  ? 170 TYR A CA  1 
ATOM   865  C  C   . TYR A 1 212 ? 44.68230 41.83117  -34.55893  1.000 19.14497  ? 170 TYR A C   1 
ATOM   866  O  O   . TYR A 1 212 ? 45.16616 42.48854  -33.64191  1.000 21.43719  ? 170 TYR A O   1 
ATOM   867  C  CB  . TYR A 1 212 ? 45.50391 42.99251  -36.61826  1.000 16.78808  ? 170 TYR A CB  1 
ATOM   868  C  CG  . TYR A 1 212 ? 46.04561 42.84496  -38.02791  1.000 17.75946  ? 170 TYR A CG  1 
ATOM   869  C  CD1 . TYR A 1 212 ? 47.15570 42.02007  -38.31625  1.000 16.81975  ? 170 TYR A CD1 1 
ATOM   870  C  CD2 . TYR A 1 212 ? 45.42139 43.49361  -39.08844  1.000 16.12420  ? 170 TYR A CD2 1 
ATOM   871  C  CE1 . TYR A 1 212 ? 47.60870 41.86012  -39.65267  1.000 11.60899  ? 170 TYR A CE1 1 
ATOM   872  C  CE2 . TYR A 1 212 ? 45.88121 43.36455  -40.39187  1.000 14.01113  ? 170 TYR A CE2 1 
ATOM   873  C  CZ  . TYR A 1 212 ? 46.95645 42.53028  -40.67354  1.000 15.41429  ? 170 TYR A CZ  1 
ATOM   874  O  OH  . TYR A 1 212 ? 47.32812 42.40775  -41.99974  1.000 15.58765  ? 170 TYR A OH  1 
ATOM   875  N  N   . ASN A 1 213 ? 43.50618 41.21286  -34.44256  1.000 14.44958  ? 171 ASN A N   1 
ATOM   876  C  CA  . ASN A 1 213 ? 42.76555 41.26214  -33.19405  1.000 16.39551  ? 171 ASN A CA  1 
ATOM   877  C  C   . ASN A 1 213 ? 42.48164 39.88082  -32.61731  1.000 23.89479  ? 171 ASN A C   1 
ATOM   878  O  O   . ASN A 1 213 ? 41.83569 39.80508  -31.56265  1.000 21.11394  ? 171 ASN A O   1 
ATOM   879  C  CB  . ASN A 1 213 ? 41.43486 42.02850  -33.37387  1.000 21.03111  ? 171 ASN A CB  1 
ATOM   880  C  CG  . ASN A 1 213 ? 40.41186 41.25640  -34.22893  1.000 27.20574  ? 171 ASN A CG  1 
ATOM   881  O  OD1 . ASN A 1 213 ? 40.77838 40.36970  -35.02877  1.000 23.11047  ? 171 ASN A OD1 1 
ATOM   882  N  ND2 . ASN A 1 213 ? 39.11897 41.59245  -34.06341  1.000 25.24278  ? 171 ASN A ND2 1 
ATOM   883  N  N   . SER A 1 214 ? 43.00002 38.79690  -33.22009  1.000 17.30215  ? 172 SER A N   1 
ATOM   884  C  CA  . SER A 1 214 ? 42.68408 37.44588  -32.77835  1.000 20.97777  ? 172 SER A CA  1 
ATOM   885  C  C   . SER A 1 214 ? 43.83287 36.80560  -32.01702  1.000 24.68032  ? 172 SER A C   1 
ATOM   886  O  O   . SER A 1 214 ? 45.00549 36.90210  -32.39678  1.000 26.27538  ? 172 SER A O   1 
ATOM   887  C  CB  . SER A 1 214 ? 42.33186 36.52640  -33.94922  1.000 19.41990  ? 172 SER A CB  1 
ATOM   888  O  OG  . SER A 1 214 ? 41.30140 37.08823  -34.71689  1.000 22.93859  ? 172 SER A OG  1 
ATOM   889  N  N   . ARG A 1 215 ? 43.45839 36.12447  -30.95961  1.000 24.76248  ? 173 ARG A N   1 
ATOM   890  C  CA  . ARG A 1 215 ? 44.36191 35.43923  -30.07273  1.000 21.24782  ? 173 ARG A CA  1 
ATOM   891  C  C   . ARG A 1 215 ? 44.41632 33.96900  -30.48772  1.000 23.07111  ? 173 ARG A C   1 
ATOM   892  O  O   . ARG A 1 215 ? 43.40207 33.38524  -30.88049  1.000 17.60553  ? 173 ARG A O   1 
ATOM   893  C  CB  . ARG A 1 215 ? 43.85745 35.62531  -28.64158  1.000 27.71406  ? 173 ARG A CB  1 
ATOM   894  C  CG  . ARG A 1 215 ? 44.23662 34.56016  -27.72645  1.000 29.18722  ? 173 ARG A CG  1 
ATOM   895  C  CD  . ARG A 1 215 ? 43.69665 34.72935  -26.31600  1.000 31.60738  ? 173 ARG A CD  1 
ATOM   896  N  NE  . ARG A 1 215 ? 43.92689 33.46517  -25.60885  1.000 41.77534  ? 173 ARG A NE  1 
ATOM   897  C  CZ  . ARG A 1 215 ? 45.12618 32.97131  -25.30242  1.000 52.19716  ? 173 ARG A CZ  1 
ATOM   898  N  NH1 . ARG A 1 215 ? 46.24090 33.65887  -25.53380  1.000 39.24518  ? 173 ARG A NH1 1 
ATOM   899  N  NH2 . ARG A 1 215 ? 45.21314 31.75189  -24.75460  1.000 41.94649  ? 173 ARG A NH2 1 
ATOM   900  N  N   . PHE A 1 216 ? 45.61224 33.39116  -30.48419  1.000 14.90787  ? 174 PHE A N   1 
ATOM   901  C  CA  . PHE A 1 216 ? 45.73595 31.97070  -30.79987  1.000 15.11271  ? 174 PHE A CA  1 
ATOM   902  C  C   . PHE A 1 216 ? 45.35727 31.11828  -29.60485  1.000 18.34875  ? 174 PHE A C   1 
ATOM   903  O  O   . PHE A 1 216 ? 45.79415 31.37833  -28.48571  1.000 19.02761  ? 174 PHE A O   1 
ATOM   904  C  CB  . PHE A 1 216 ? 47.15327 31.62560  -31.23360  1.000 17.03518  ? 174 PHE A CB  1 
ATOM   905  C  CG  . PHE A 1 216 ? 47.37557 30.15148  -31.40301  1.000 12.99003  ? 174 PHE A CG  1 
ATOM   906  C  CD1 . PHE A 1 216 ? 47.13143 29.52779  -32.61684  1.000 12.01198  ? 174 PHE A CD1 1 
ATOM   907  C  CD2 . PHE A 1 216 ? 47.81831 29.38947  -30.33424  1.000 12.71251  ? 174 PHE A CD2 1 
ATOM   908  C  CE1 . PHE A 1 216 ? 47.35192 28.15328  -32.74929  1.000 13.14125  ? 174 PHE A CE1 1 
ATOM   909  C  CE2 . PHE A 1 216 ? 48.00711 28.01901  -30.46675  1.000 13.84677  ? 174 PHE A CE2 1 
ATOM   910  C  CZ  . PHE A 1 216 ? 47.76989 27.41518  -31.66939  1.000 14.96417  ? 174 PHE A CZ  1 
ATOM   911  N  N   . GLU A 1 217 ? 44.57715 30.06047  -29.84641  1.000 14.74082  ? 175 GLU A N   1 
ATOM   912  C  CA  . GLU A 1 217 ? 44.18668 29.14166  -28.78114  1.000 15.39471  ? 175 GLU A CA  1 
ATOM   913  C  C   . GLU A 1 217 ? 44.80663 27.75055  -28.90920  1.000 16.39148  ? 175 GLU A C   1 
ATOM   914  O  O   . GLU A 1 217 ? 45.42146 27.25338  -27.95855  1.000 16.40860  ? 175 GLU A O   1 
ATOM   915  C  CB  . GLU A 1 217 ? 42.65214 29.02813  -28.74506  1.000 20.34884  ? 175 GLU A CB  1 
ATOM   916  C  CG  . GLU A 1 217 ? 41.96571 30.42412  -28.53509  1.000 15.32749  ? 175 GLU A CG  1 
ATOM   917  C  CD  . GLU A 1 217 ? 42.12398 30.95162  -27.12082  1.000 18.77545  ? 175 GLU A CD  1 
ATOM   918  O  OE1 . GLU A 1 217 ? 42.60452 30.21655  -26.22848  1.000 22.98501  ? 175 GLU A OE1 1 
ATOM   919  O  OE2 . GLU A 1 217 ? 41.76518 32.11276  -26.87712  1.000 18.03596  ? 175 GLU A OE2 1 
ATOM   920  N  N   . SER A 1 218 ? 44.70308 27.11336  -30.06989  1.000 14.24430  ? 176 SER A N   1 
ATOM   921  C  CA  . SER A 1 218 ? 45.11325 25.72611  -30.17279  1.000 15.04173  ? 176 SER A CA  1 
ATOM   922  C  C   . SER A 1 218 ? 45.15441 25.35437  -31.63568  1.000 16.48742  ? 176 SER A C   1 
ATOM   923  O  O   . SER A 1 218 ? 44.48893 25.96973  -32.46813  1.000 17.45478  ? 176 SER A O   1 
ATOM   924  C  CB  . SER A 1 218 ? 44.16020 24.78387  -29.40616  1.000 27.95049  ? 176 SER A CB  1 
ATOM   925  O  OG  . SER A 1 218 ? 44.89302 23.94767  -28.52171  1.000 34.61008  ? 176 SER A OG  1 
ATOM   926  N  N   . VAL A 1 219 ? 45.96129 24.35323  -31.94257  1.000 12.68721  ? 177 VAL A N   1 
ATOM   927  C  CA  . VAL A 1 219 ? 45.85770 23.69627  -33.23194  1.000 15.61512  ? 177 VAL A CA  1 
ATOM   928  C  C   . VAL A 1 219 ? 44.65980 22.75225  -33.14433  1.000 16.98708  ? 177 VAL A C   1 
ATOM   929  O  O   . VAL A 1 219 ? 44.55024 21.94960  -32.21157  1.000 19.99996  ? 177 VAL A O   1 
ATOM   930  C  CB  . VAL A 1 219 ? 47.16407 22.96254  -33.58593  1.000 15.31925  ? 177 VAL A CB  1 
ATOM   931  C  CG1 . VAL A 1 219 ? 47.10154 22.37892  -34.98480  1.000 12.41733  ? 177 VAL A CG1 1 
ATOM   932  C  CG2 . VAL A 1 219 ? 48.38317 23.96990  -33.48985  1.000 11.73452  ? 177 VAL A CG2 1 
ATOM   933  N  N   . ALA A 1 220 ? 43.73796 22.88225  -34.08412  1.000 16.50664  ? 178 ALA A N   1 
ATOM   934  C  CA  . ALA A 1 220 ? 42.43843 22.23867  -33.92530  1.000 14.52442  ? 178 ALA A CA  1 
ATOM   935  C  C   . ALA A 1 220 ? 41.65082 22.20845  -35.21528  1.000 18.38159  ? 178 ALA A C   1 
ATOM   936  O  O   . ALA A 1 220 ? 41.49785 23.26034  -35.84416  1.000 16.27929  ? 178 ALA A O   1 
ATOM   937  C  CB  . ALA A 1 220 ? 41.61277 22.96445  -32.88274  1.000 11.95054  ? 178 ALA A CB  1 
ATOM   938  N  N   . TRP A 1 221 ? 41.10426 21.03661  -35.59649  1.000 17.45031  ? 179 TRP A N   1 
ATOM   939  C  CA  . TRP A 1 221 ? 40.02128 20.99583  -36.58432  1.000 15.17096  ? 179 TRP A CA  1 
ATOM   940  C  C   . TRP A 1 221 ? 38.66095 20.61474  -35.97319  1.000 20.74931  ? 179 TRP A C   1 
ATOM   941  O  O   . TRP A 1 221 ? 37.65946 20.50624  -36.68875  1.000 17.68179  ? 179 TRP A O   1 
ATOM   942  C  CB  . TRP A 1 221 ? 40.38268 20.09414  -37.76728  1.000 13.23885  ? 179 TRP A CB  1 
ATOM   943  C  CG  . TRP A 1 221 ? 41.03044 18.74135  -37.45519  1.000 25.02645  ? 179 TRP A CG  1 
ATOM   944  C  CD1 . TRP A 1 221 ? 42.33140 18.37438  -37.71329  1.000 19.25073  ? 179 TRP A CD1 1 
ATOM   945  C  CD2 . TRP A 1 221 ? 40.39284 17.58021  -36.89842  1.000 14.78392  ? 179 TRP A CD2 1 
ATOM   946  N  NE1 . TRP A 1 221 ? 42.54996 17.09018  -37.32466  1.000 17.73245  ? 179 TRP A NE1 1 
ATOM   947  C  CE2 . TRP A 1 221 ? 41.38527 16.56184  -36.82439  1.000 17.35622  ? 179 TRP A CE2 1 
ATOM   948  C  CE3 . TRP A 1 221 ? 39.09721 17.31326  -36.41731  1.000 15.29885  ? 179 TRP A CE3 1 
ATOM   949  C  CZ2 . TRP A 1 221 ? 41.12525 15.29739  -36.29655  1.000 15.50477  ? 179 TRP A CZ2 1 
ATOM   950  C  CZ3 . TRP A 1 221 ? 38.81455 16.03616  -35.90497  1.000 16.11812  ? 179 TRP A CZ3 1 
ATOM   951  C  CH2 . TRP A 1 221 ? 39.82651 15.04053  -35.84823  1.000 22.27168  ? 179 TRP A CH2 1 
ATOM   952  N  N   . SER A 1 222 ? 38.59163 20.48280  -34.65727  1.000 11.46288  ? 180 SER A N   1 
ATOM   953  C  CA  . SER A 1 222 ? 37.35258 20.33581  -33.91766  1.000 18.28429  ? 180 SER A CA  1 
ATOM   954  C  C   . SER A 1 222 ? 37.70550 20.90953  -32.56974  1.000 13.92884  ? 180 SER A C   1 
ATOM   955  O  O   . SER A 1 222 ? 38.85424 20.76312  -32.13658  1.000 12.82051  ? 180 SER A O   1 
ATOM   956  C  CB  . SER A 1 222 ? 36.88915 18.86457  -33.79586  1.000 14.78609  ? 180 SER A CB  1 
ATOM   957  O  OG  . SER A 1 222 ? 35.73843 18.74408  -32.95171  1.000 17.20070  ? 180 SER A OG  1 
ATOM   958  N  N   . ALA A 1 223 ? 36.77356 21.62745  -31.93686  1.000 11.64183  ? 181 ALA A N   1 
ATOM   959  C  CA  . ALA A 1 223 ? 37.18473 22.29693  -30.71598  1.000 14.74855  ? 181 ALA A CA  1 
ATOM   960  C  C   . ALA A 1 223 ? 36.01857 22.52613  -29.77310  1.000 18.68754  ? 181 ALA A C   1 
ATOM   961  O  O   . ALA A 1 223 ? 34.84320 22.47099  -30.16214  1.000 16.88685  ? 181 ALA A O   1 
ATOM   962  C  CB  . ALA A 1 223 ? 37.91619 23.63737  -31.02169  1.000 13.57228  ? 181 ALA A CB  1 
ATOM   963  N  N   . SER A 1 224 ? 36.38711 22.79614  -28.51690  1.000 14.84645  ? 182 SER A N   1 
ATOM   964  C  CA  . SER A 1 224 ? 35.50038 23.27680  -27.47162  1.000 23.60881  ? 182 SER A CA  1 
ATOM   965  C  C   . SER A 1 224 ? 36.25550 24.29243  -26.60904  1.000 21.46871  ? 182 SER A C   1 
ATOM   966  O  O   . SER A 1 224 ? 37.48266 24.29698  -26.57767  1.000 19.15503  ? 182 SER A O   1 
ATOM   967  C  CB  . SER A 1 224 ? 35.01578 22.11683  -26.61076  1.000 21.70818  ? 182 SER A CB  1 
ATOM   968  O  OG  . SER A 1 224 ? 34.15979 22.61610  -25.62462  1.000 27.22704  ? 182 SER A OG  1 
ATOM   969  N  N   . ALA A 1 225 ? 35.52630 25.15476  -25.89788  1.000 17.98564  ? 183 ALA A N   1 
ATOM   970  C  CA  . ALA A 1 225 ? 36.17768 26.12111  -25.00436  1.000 20.29823  ? 183 ALA A CA  1 
ATOM   971  C  C   . ALA A 1 225 ? 35.16092 26.65207  -23.99852  1.000 19.58579  ? 183 ALA A C   1 
ATOM   972  O  O   . ALA A 1 225 ? 33.96328 26.72763  -24.28641  1.000 18.47285  ? 183 ALA A O   1 
ATOM   973  C  CB  . ALA A 1 225 ? 36.84145 27.28898  -25.77395  1.000 17.89540  ? 183 ALA A CB  1 
ATOM   974  N  N   . CYS A 1 226 ? 35.63316 26.96208  -22.79717  1.000 18.67283  ? 184 CYS A N   1 
ATOM   975  C  CA  . CYS A 1 226 ? 34.73759 27.50298  -21.77785  1.000 19.71860  ? 184 CYS A CA  1 
ATOM   976  C  C   . CYS A 1 226 ? 35.60452 28.00076  -20.63258  1.000 23.30372  ? 184 CYS A C   1 
ATOM   977  O  O   . CYS A 1 226 ? 36.79828 27.71178  -20.56946  1.000 21.76141  ? 184 CYS A O   1 
ATOM   978  C  CB  . CYS A 1 226 ? 33.70694 26.47642  -21.28881  1.000 20.31587  ? 184 CYS A CB  1 
ATOM   979  S  SG  . CYS A 1 226 ? 34.47486 24.90324  -20.71095  1.000 21.87796  ? 184 CYS A SG  1 
ATOM   980  N  N   . HIS A 1 227 ? 34.99682 28.78234  -19.74295  1.000 23.55758  ? 185 HIS A N   1 
ATOM   981  C  CA  . HIS A 1 227 ? 35.70982 29.48094  -18.68056  1.000 18.50066  ? 185 HIS A CA  1 
ATOM   982  C  C   . HIS A 1 227 ? 35.08608 29.11291  -17.34825  1.000 23.98037  ? 185 HIS A C   1 
ATOM   983  O  O   . HIS A 1 227 ? 33.86442 29.19850  -17.19846  1.000 22.66907  ? 185 HIS A O   1 
ATOM   984  C  CB  . HIS A 1 227 ? 35.62245 30.99016  -18.90153  1.000 21.10714  ? 185 HIS A CB  1 
ATOM   985  C  CG  . HIS A 1 227 ? 36.60693 31.77743  -18.09507  1.000 22.15192  ? 185 HIS A CG  1 
ATOM   986  N  ND1 . HIS A 1 227 ? 36.48453 31.95154  -16.73432  1.000 26.67552  ? 185 HIS A ND1 1 
ATOM   987  C  CD2 . HIS A 1 227 ? 37.72885 32.44016  -18.46029  1.000 22.15129  ? 185 HIS A CD2 1 
ATOM   988  C  CE1 . HIS A 1 227 ? 37.49084 32.68428  -16.29395  1.000 27.97659  ? 185 HIS A CE1 1 
ATOM   989  N  NE2 . HIS A 1 227 ? 38.26307 32.98371  -17.32075  1.000 20.07662  ? 185 HIS A NE2 1 
ATOM   990  N  N   . ASP A 1 228 ? 35.90018 28.73128  -16.36786  1.000 21.04244  ? 186 ASP A N   1 
ATOM   991  C  CA  . ASP A 1 228 ? 35.33743 28.21395  -15.12614  1.000 22.50391  ? 186 ASP A CA  1 
ATOM   992  C  C   . ASP A 1 228 ? 35.18909 29.27709  -14.03970  1.000 23.92904  ? 186 ASP A C   1 
ATOM   993  O  O   . ASP A 1 228 ? 34.86649 28.94729  -12.89394  1.000 22.02280  ? 186 ASP A O   1 
ATOM   994  C  CB  . ASP A 1 228 ? 36.17259 27.04007  -14.60871  1.000 22.99178  ? 186 ASP A CB  1 
ATOM   995  C  CG  . ASP A 1 228 ? 37.60589 27.45238  -14.21360  1.000 29.16924  ? 186 ASP A CG  1 
ATOM   996  O  OD1 . ASP A 1 228 ? 38.01248 28.61712  -14.46380  1.000 21.74022  ? 186 ASP A OD1 1 
ATOM   997  O  OD2 . ASP A 1 228 ? 38.31657 26.60451  -13.63794  1.000 22.81280  ? 186 ASP A OD2 1 
ATOM   998  N  N   . GLY A 1 229 ? 35.39197 30.53877  -14.36873  1.000 23.83919  ? 187 GLY A N   1 
ATOM   999  C  CA  . GLY A 1 229 ? 35.44492 31.58251  -13.37720  1.000 22.97207  ? 187 GLY A CA  1 
ATOM   1000 C  C   . GLY A 1 229 ? 36.85562 32.03733  -13.07177  1.000 28.31828  ? 187 GLY A C   1 
ATOM   1001 O  O   . GLY A 1 229 ? 37.05323 33.16778  -12.61678  1.000 27.87995  ? 187 GLY A O   1 
ATOM   1002 N  N   . ILE A 1 230 ? 37.83816 31.19325  -13.36313  1.000 29.03834  ? 188 ILE A N   1 
ATOM   1003 C  CA  . ILE A 1 230 ? 39.23690 31.44811  -13.04811  1.000 26.82291  ? 188 ILE A CA  1 
ATOM   1004 C  C   . ILE A 1 230 ? 40.08376 31.53600  -14.31456  1.000 28.76183  ? 188 ILE A C   1 
ATOM   1005 O  O   . ILE A 1 230 ? 40.75981 32.53677  -14.53708  1.000 29.90666  ? 188 ILE A O   1 
ATOM   1006 C  CB  . ILE A 1 230 ? 39.78346 30.39272  -12.06430  1.000 30.98576  ? 188 ILE A CB  1 
ATOM   1007 C  CG1 . ILE A 1 230 ? 39.03763 30.59118  -10.73978  1.000 26.46224  ? 188 ILE A CG1 1 
ATOM   1008 C  CG2 . ILE A 1 230 ? 41.31375 30.53655  -11.84332  1.000 28.19940  ? 188 ILE A CG2 1 
ATOM   1009 C  CD1 . ILE A 1 230 ? 39.33573 29.56874  -9.73783   1.000 38.62348  ? 188 ILE A CD1 1 
ATOM   1010 N  N   . SER A 1 231 ? 40.00585 30.52247  -15.19402  1.000 20.35819  ? 189 SER A N   1 
ATOM   1011 C  CA  . SER A 1 231 ? 40.77770 30.55599  -16.43271  1.000 17.99951  ? 189 SER A CA  1 
ATOM   1012 C  C   . SER A 1 231 ? 40.01486 29.93626  -17.59472  1.000 20.80887  ? 189 SER A C   1 
ATOM   1013 O  O   . SER A 1 231 ? 39.05828 29.18601  -17.40307  1.000 20.80862  ? 189 SER A O   1 
ATOM   1014 C  CB  . SER A 1 231 ? 42.12948 29.82531  -16.27110  1.000 21.50457  ? 189 SER A CB  1 
ATOM   1015 O  OG  . SER A 1 231 ? 42.84371 30.40533  -15.19958  1.000 23.14456  ? 189 SER A OG  1 
ATOM   1016 N  N   . TRP A 1 232 ? 40.49013 30.21633  -18.81351  1.000 17.96067  ? 190 TRP A N   1 
ATOM   1017 C  CA  . TRP A 1 232 ? 39.95295 29.57532  -20.01187  1.000 13.85808  ? 190 TRP A CA  1 
ATOM   1018 C  C   . TRP A 1 232 ? 40.40660 28.12874  -20.10999  1.000 21.35353  ? 190 TRP A C   1 
ATOM   1019 O  O   . TRP A 1 232 ? 41.60060 27.83237  -20.00683  1.000 16.65286  ? 190 TRP A O   1 
ATOM   1020 C  CB  . TRP A 1 232 ? 40.40763 30.30560  -21.27018  1.000 16.92400  ? 190 TRP A CB  1 
ATOM   1021 C  CG  . TRP A 1 232 ? 39.65522 31.54815  -21.47760  1.000 24.31667  ? 190 TRP A CG  1 
ATOM   1022 C  CD1 . TRP A 1 232 ? 40.07804 32.81648  -21.22170  1.000 20.38826  ? 190 TRP A CD1 1 
ATOM   1023 C  CD2 . TRP A 1 232 ? 38.28907 31.64765  -21.94776  1.000 20.16035  ? 190 TRP A CD2 1 
ATOM   1024 N  NE1 . TRP A 1 232 ? 39.06466 33.71206  -21.53287  1.000 25.99205  ? 190 TRP A NE1 1 
ATOM   1025 C  CE2 . TRP A 1 232 ? 37.95999 33.01700  -21.97634  1.000 25.68675  ? 190 TRP A CE2 1 
ATOM   1026 C  CE3 . TRP A 1 232 ? 37.31742 30.70128  -22.33646  1.000 24.75088  ? 190 TRP A CE3 1 
ATOM   1027 C  CZ2 . TRP A 1 232 ? 36.69429 33.47816  -22.39652  1.000 24.58691  ? 190 TRP A CZ2 1 
ATOM   1028 C  CZ3 . TRP A 1 232 ? 36.04321 31.16132  -22.76396  1.000 20.90025  ? 190 TRP A CZ3 1 
ATOM   1029 C  CH2 . TRP A 1 232 ? 35.75838 32.53309  -22.78613  1.000 24.41234  ? 190 TRP A CH2 1 
ATOM   1030 N  N   . LEU A 1 233 ? 39.44885 27.23529  -20.31799  1.000 20.64259  ? 191 LEU A N   1 
ATOM   1031 C  CA  . LEU A 1 233 ? 39.70425 25.85543  -20.71698  1.000 19.43360  ? 191 LEU A CA  1 
ATOM   1032 C  C   . LEU A 1 233 ? 39.51293 25.79210  -22.22157  1.000 19.35148  ? 191 LEU A C   1 
ATOM   1033 O  O   . LEU A 1 233 ? 38.46884 26.20328  -22.72808  1.000 19.56109  ? 191 LEU A O   1 
ATOM   1034 C  CB  . LEU A 1 233 ? 38.72458 24.92021  -20.00846  1.000 18.66601  ? 191 LEU A CB  1 
ATOM   1035 C  CG  . LEU A 1 233 ? 38.71205 23.44203  -20.41491  1.000 27.90751  ? 191 LEU A CG  1 
ATOM   1036 C  CD1 . LEU A 1 233 ? 39.97726 22.75156  -19.93447  1.000 18.38634  ? 191 LEU A CD1 1 
ATOM   1037 C  CD2 . LEU A 1 233 ? 37.46353 22.73050  -19.87337  1.000 19.33364  ? 191 LEU A CD2 1 
ATOM   1038 N  N   . THR A 1 234 ? 40.51226 25.31958  -22.94617  1.000 16.79931  ? 192 THR A N   1 
ATOM   1039 C  CA  . THR A 1 234 ? 40.35510 25.13387  -24.38484  1.000 16.40744  ? 192 THR A CA  1 
ATOM   1040 C  C   . THR A 1 234 ? 40.68558 23.68587  -24.73112  1.000 20.17908  ? 192 THR A C   1 
ATOM   1041 O  O   . THR A 1 234 ? 41.55790 23.08063  -24.10206  1.000 21.27894  ? 192 THR A O   1 
ATOM   1042 C  CB  . THR A 1 234 ? 41.24246 26.08047  -25.19065  1.000 20.05251  ? 192 THR A CB  1 
ATOM   1043 O  OG1 . THR A 1 234 ? 42.62067 25.83954  -24.85701  1.000 26.36918  ? 192 THR A OG1 1 
ATOM   1044 C  CG2 . THR A 1 234 ? 40.90078 27.56340  -24.89400  1.000 16.75991  ? 192 THR A CG2 1 
ATOM   1045 N  N   . ILE A 1 235 ? 39.95368 23.12469  -25.70140  1.000 19.49885  ? 193 ILE A N   1 
ATOM   1046 C  CA  . ILE A 1 235 ? 40.15339 21.76087  -26.16999  1.000 22.40160  ? 193 ILE A CA  1 
ATOM   1047 C  C   . ILE A 1 235 ? 40.29244 21.81752  -27.68076  1.000 21.90820  ? 193 ILE A C   1 
ATOM   1048 O  O   . ILE A 1 235 ? 39.37541 22.27418  -28.37356  1.000 19.86961  ? 193 ILE A O   1 
ATOM   1049 C  CB  . ILE A 1 235 ? 38.99623 20.84112  -25.75906  1.000 18.19115  ? 193 ILE A CB  1 
ATOM   1050 C  CG1 . ILE A 1 235 ? 38.86327 20.91085  -24.23363  1.000 19.82892  ? 193 ILE A CG1 1 
ATOM   1051 C  CG2 . ILE A 1 235 ? 39.23177 19.38964  -26.32674  1.000 15.38130  ? 193 ILE A CG2 1 
ATOM   1052 C  CD1 . ILE A 1 235 ? 37.61921 20.26366  -23.67557  1.000 18.03705  ? 193 ILE A CD1 1 
ATOM   1053 N  N   . GLY A 1 236 ? 41.45112 21.40329  -28.19144  1.000 15.43965  ? 194 GLY A N   1 
ATOM   1054 C  CA  . GLY A 1 236 ? 41.67458 21.47869  -29.62118  1.000 15.35262  ? 194 GLY A CA  1 
ATOM   1055 C  C   . GLY A 1 236 ? 42.10801 20.11970  -30.12106  1.000 18.97000  ? 194 GLY A C   1 
ATOM   1056 O  O   . GLY A 1 236 ? 43.11771 19.60144  -29.64362  1.000 19.31778  ? 194 GLY A O   1 
ATOM   1057 N  N   . ILE A 1 237 ? 41.34538 19.52539  -31.04826  1.000 13.54875  ? 195 ILE A N   1 
ATOM   1058 C  CA  . ILE A 1 237 ? 41.65485 18.22154  -31.61463  1.000 18.55922  ? 195 ILE A CA  1 
ATOM   1059 C  C   . ILE A 1 237 ? 42.37596 18.41239  -32.93981  1.000 18.32936  ? 195 ILE A C   1 
ATOM   1060 O  O   . ILE A 1 237 ? 41.87058 19.09746  -33.84428  1.000 19.27814  ? 195 ILE A O   1 
ATOM   1061 C  CB  . ILE A 1 237 ? 40.37704 17.38056  -31.81823  1.000 15.35452  ? 195 ILE A CB  1 
ATOM   1062 C  CG1 . ILE A 1 237 ? 39.64891 17.18151  -30.48629  1.000 16.45024  ? 195 ILE A CG1 1 
ATOM   1063 C  CG2 . ILE A 1 237 ? 40.75792 16.06852  -32.46508  1.000 10.09935  ? 195 ILE A CG2 1 
ATOM   1064 C  CD1 . ILE A 1 237 ? 38.13890 16.62105  -30.59000  1.000 14.21291  ? 195 ILE A CD1 1 
ATOM   1065 N  N   . SER A 1 238 ? 43.51973 17.73386  -33.09163  1.000 15.58063  ? 196 SER A N   1 
ATOM   1066 C  CA  . SER A 1 238 ? 44.22533 17.68644  -34.35895  1.000 13.50955  ? 196 SER A CA  1 
ATOM   1067 C  C   . SER A 1 238 ? 44.78136 16.27693  -34.51163  1.000 20.31374  ? 196 SER A C   1 
ATOM   1068 O  O   . SER A 1 238 ? 44.58967 15.41922  -33.64194  1.000 21.17242  ? 196 SER A O   1 
ATOM   1069 C  CB  . SER A 1 238 ? 45.32913 18.75654  -34.44089  1.000 13.68557  ? 196 SER A CB  1 
ATOM   1070 O  OG  . SER A 1 238 ? 45.78916 18.91618  -35.77933  1.000 18.19087  ? 196 SER A OG  1 
ATOM   1071 N  N   . GLY A 1 239 ? 45.46619 16.02576  -35.62790  1.000 19.60826  ? 197 GLY A N   1 
ATOM   1072 C  CA  . GLY A 1 239 ? 45.98984 14.69989  -35.90159  1.000 18.37609  ? 197 GLY A CA  1 
ATOM   1073 C  C   . GLY A 1 239 ? 45.27024 13.94005  -37.00399  1.000 20.70168  ? 197 GLY A C   1 
ATOM   1074 O  O   . GLY A 1 239 ? 44.29121 14.40856  -37.60168  1.000 18.80626  ? 197 GLY A O   1 
ATOM   1075 N  N   . PRO A 1 240 ? 45.75297 12.73417  -37.29474  1.000 19.25879  ? 198 PRO A N   1 
ATOM   1076 C  CA  . PRO A 1 240 ? 45.12554 11.92656  -38.34492  1.000 16.72965  ? 198 PRO A CA  1 
ATOM   1077 C  C   . PRO A 1 240 ? 43.75139 11.45329  -37.91778  1.000 16.83196  ? 198 PRO A C   1 
ATOM   1078 O  O   . PRO A 1 240 ? 43.43562 11.35538  -36.72597  1.000 14.17462  ? 198 PRO A O   1 
ATOM   1079 C  CB  . PRO A 1 240 ? 46.08898 10.74107  -38.52080  1.000 17.04693  ? 198 PRO A CB  1 
ATOM   1080 C  CG  . PRO A 1 240 ? 46.73228 10.59593  -37.16889  1.000 20.18614  ? 198 PRO A CG  1 
ATOM   1081 C  CD  . PRO A 1 240 ? 46.87159 12.02810  -36.63734  1.000 14.88184  ? 198 PRO A CD  1 
ATOM   1082 N  N   . ASP A 1 241 ? 42.93694 11.12853  -38.93116  1.000 16.19981  ? 199 ASP A N   1 
ATOM   1083 C  CA  . ASP A 1 241 ? 41.60172 10.57676  -38.66986  1.000 19.77969  ? 199 ASP A CA  1 
ATOM   1084 C  C   . ASP A 1 241 ? 41.65515 9.32746   -37.80947  1.000 21.40051  ? 199 ASP A C   1 
ATOM   1085 O  O   . ASP A 1 241 ? 40.75589 9.09249   -37.00787  1.000 17.90306  ? 199 ASP A O   1 
ATOM   1086 C  CB  . ASP A 1 241 ? 40.89371 10.29373  -39.99086  1.000 20.31474  ? 199 ASP A CB  1 
ATOM   1087 C  CG  . ASP A 1 241 ? 40.37403 11.57094  -40.64576  1.000 23.07756  ? 199 ASP A CG  1 
ATOM   1088 O  OD1 . ASP A 1 241 ? 40.51585 12.65630  -40.02272  1.000 21.23146  ? 199 ASP A OD1 1 
ATOM   1089 O  OD2 . ASP A 1 241 ? 39.84419 11.49638  -41.78139  1.000 29.69699  ? 199 ASP A OD2 1 
ATOM   1090 N  N   . ASN A 1 242 ? 42.70659 8.52148   -37.92946  1.000 18.77431  ? 200 ASN A N   1 
ATOM   1091 C  CA  . ASN A 1 242 ? 42.70739 7.24857   -37.22671  1.000 22.55440  ? 200 ASN A CA  1 
ATOM   1092 C  C   . ASN A 1 242 ? 43.35540 7.31278   -35.84952  1.000 21.26609  ? 200 ASN A C   1 
ATOM   1093 O  O   . ASN A 1 242 ? 43.49387 6.27499   -35.20541  1.000 21.94587  ? 200 ASN A O   1 
ATOM   1094 C  CB  . ASN A 1 242 ? 43.39377 6.18902   -38.07051  1.000 19.81867  ? 200 ASN A CB  1 
ATOM   1095 C  CG  . ASN A 1 242 ? 44.88919 6.46584   -38.25119  1.000 27.52120  ? 200 ASN A CG  1 
ATOM   1096 O  OD1 . ASN A 1 242 ? 45.46564 7.38831   -37.65200  1.000 26.32151  ? 200 ASN A OD1 1 
ATOM   1097 N  ND2 . ASN A 1 242 ? 45.52164 5.66200   -39.08208  1.000 29.40931  ? 200 ASN A ND2 1 
ATOM   1098 N  N   . GLY A 1 243 ? 43.70409 8.49549   -35.36668  1.000 17.82148  ? 201 GLY A N   1 
ATOM   1099 C  CA  . GLY A 1 243 ? 44.34573 8.62368   -34.07259  1.000 17.38067  ? 201 GLY A CA  1 
ATOM   1100 C  C   . GLY A 1 243 ? 44.40953 10.05415  -33.56795  1.000 23.82064  ? 201 GLY A C   1 
ATOM   1101 O  O   . GLY A 1 243 ? 45.41193 10.45087  -32.97333  1.000 18.95064  ? 201 GLY A O   1 
ATOM   1102 N  N   . ALA A 1 244 ? 43.35683 10.83553  -33.81435  1.000 18.22016  ? 202 ALA A N   1 
ATOM   1103 C  CA  . ALA A 1 244 ? 43.32875 12.23167  -33.40162  1.000 15.74183  ? 202 ALA A CA  1 
ATOM   1104 C  C   . ALA A 1 244 ? 43.51064 12.34910  -31.88838  1.000 14.78177  ? 202 ALA A C   1 
ATOM   1105 O  O   . ALA A 1 244 ? 43.17229 11.44530  -31.12747  1.000 16.90465  ? 202 ALA A O   1 
ATOM   1106 C  CB  . ALA A 1 244 ? 42.01725 12.89426  -33.84904  1.000 18.50854  ? 202 ALA A CB  1 
ATOM   1107 N  N   . VAL A 1 245 ? 44.06795 13.47942  -31.45922  1.000 16.13392  ? 203 VAL A N   1 
ATOM   1108 C  CA  . VAL A 1 245 ? 44.36010 13.78190  -30.05737  1.000 14.62083  ? 203 VAL A CA  1 
ATOM   1109 C  C   . VAL A 1 245 ? 43.80013 15.15936  -29.72619  1.000 20.86061  ? 203 VAL A C   1 
ATOM   1110 O  O   . VAL A 1 245 ? 44.14739 16.14436  -30.37989  1.000 17.84399  ? 203 VAL A O   1 
ATOM   1111 C  CB  . VAL A 1 245 ? 45.88192 13.72631  -29.78586  1.000 18.38561  ? 203 VAL A CB  1 
ATOM   1112 C  CG1 . VAL A 1 245 ? 46.27038 14.42234  -28.47777  1.000 12.08370  ? 203 VAL A CG1 1 
ATOM   1113 C  CG2 . VAL A 1 245 ? 46.31769 12.26058  -29.72923  1.000 16.56775  ? 203 VAL A CG2 1 
ATOM   1114 N  N   . ALA A 1 246 ? 42.92961 15.22510  -28.72273  1.000 20.80107  ? 204 ALA A N   1 
ATOM   1115 C  CA  . ALA A 1 246 ? 42.46556 16.49049  -28.18780  1.000 20.98895  ? 204 ALA A CA  1 
ATOM   1116 C  C   . ALA A 1 246 ? 43.51140 16.98526  -27.20650  1.000 20.24518  ? 204 ALA A C   1 
ATOM   1117 O  O   . ALA A 1 246 ? 43.85690 16.28158  -26.25074  1.000 19.69363  ? 204 ALA A O   1 
ATOM   1118 C  CB  . ALA A 1 246 ? 41.10228 16.34163  -27.51516  1.000 17.50782  ? 204 ALA A CB  1 
ATOM   1119 N  N   . VAL A 1 247 ? 44.02132 18.18323  -27.45057  1.000 14.74171  ? 205 VAL A N   1 
ATOM   1120 C  CA  . VAL A 1 247 ? 44.96395 18.83310  -26.55169  1.000 15.89333  ? 205 VAL A CA  1 
ATOM   1121 C  C   . VAL A 1 247 ? 44.16715 19.76620  -25.65829  1.000 18.52679  ? 205 VAL A C   1 
ATOM   1122 O  O   . VAL A 1 247 ? 43.43019 20.62798  -26.15326  1.000 20.25429  ? 205 VAL A O   1 
ATOM   1123 C  CB  . VAL A 1 247 ? 46.04505 19.59337  -27.32971  1.000 17.36417  ? 205 VAL A CB  1 
ATOM   1124 C  CG1 . VAL A 1 247 ? 46.90219 20.37311  -26.36880  1.000 18.73368  ? 205 VAL A CG1 1 
ATOM   1125 C  CG2 . VAL A 1 247 ? 46.87176 18.62822  -28.14896  1.000 15.34153  ? 205 VAL A CG2 1 
ATOM   1126 N  N   . VAL A 1 248 ? 44.29130 19.57659  -24.34755  1.000 17.78479  ? 206 VAL A N   1 
ATOM   1127 C  CA  . VAL A 1 248 ? 43.51232 20.31470  -23.36727  1.000 20.03148  ? 206 VAL A CA  1 
ATOM   1128 C  C   . VAL A 1 248 ? 44.42958 21.35708  -22.75260  1.000 23.13509  ? 206 VAL A C   1 
ATOM   1129 O  O   . VAL A 1 248 ? 45.53508 21.03146  -22.28946  1.000 19.45075  ? 206 VAL A O   1 
ATOM   1130 C  CB  . VAL A 1 248 ? 42.93608 19.38185  -22.28203  1.000 22.15505  ? 206 VAL A CB  1 
ATOM   1131 C  CG1 . VAL A 1 248 ? 42.04558 20.16663  -21.33725  1.000 20.23196  ? 206 VAL A CG1 1 
ATOM   1132 C  CG2 . VAL A 1 248 ? 42.13607 18.23680  -22.90507  1.000 18.94778  ? 206 VAL A CG2 1 
ATOM   1133 N  N   . LYS A 1 249 ? 43.99508 22.61597  -22.77529  1.000 18.72658  ? 207 LYS A N   1 
ATOM   1134 C  CA  . LYS A 1 249 ? 44.75745 23.70419  -22.18726  1.000 18.78241  ? 207 LYS A CA  1 
ATOM   1135 C  C   . LYS A 1 249 ? 43.89314 24.38638  -21.15160  1.000 21.83928  ? 207 LYS A C   1 
ATOM   1136 O  O   . LYS A 1 249 ? 42.69074 24.57242  -21.35164  1.000 21.11119  ? 207 LYS A O   1 
ATOM   1137 C  CB  . LYS A 1 249 ? 45.20460 24.74652  -23.21660  1.000 20.89706  ? 207 LYS A CB  1 
ATOM   1138 C  CG  . LYS A 1 249 ? 46.29713 24.29731  -24.11855  1.000 18.76176  ? 207 LYS A CG  1 
ATOM   1139 C  CD  . LYS A 1 249 ? 46.38471 25.18070  -25.31021  1.000 19.91571  ? 207 LYS A CD  1 
ATOM   1140 C  CE  . LYS A 1 249 ? 47.57626 24.77075  -26.16295  1.000 19.06549  ? 207 LYS A CE  1 
ATOM   1141 N  NZ  . LYS A 1 249 ? 47.92246 25.83712  -27.15882  1.000 19.12521  ? 207 LYS A NZ  1 
ATOM   1142 N  N   . TYR A 1 250 ? 44.52135 24.76765  -20.05727  1.000 22.21136  ? 208 TYR A N   1 
ATOM   1143 C  CA  . TYR A 1 250 ? 43.89775 25.58026  -19.03132  1.000 17.55575  ? 208 TYR A CA  1 
ATOM   1144 C  C   . TYR A 1 250 ? 44.79735 26.79469  -18.89325  1.000 27.67338  ? 208 TYR A C   1 
ATOM   1145 O  O   . TYR A 1 250 ? 46.00871 26.64936  -18.65624  1.000 21.71896  ? 208 TYR A O   1 
ATOM   1146 C  CB  . TYR A 1 250 ? 43.79945 24.79737  -17.72498  1.000 16.17864  ? 208 TYR A CB  1 
ATOM   1147 C  CG  . TYR A 1 250 ? 43.00899 25.43252  -16.61839  1.000 22.31977  ? 208 TYR A CG  1 
ATOM   1148 C  CD1 . TYR A 1 250 ? 41.60289 25.49347  -16.67644  1.000 22.73865  ? 208 TYR A CD1 1 
ATOM   1149 C  CD2 . TYR A 1 250 ? 43.64594 25.91826  -15.47823  1.000 16.18634  ? 208 TYR A CD2 1 
ATOM   1150 C  CE1 . TYR A 1 250 ? 40.85734 26.07972  -15.62858  1.000 17.93960  ? 208 TYR A CE1 1 
ATOM   1151 C  CE2 . TYR A 1 250 ? 42.92001 26.51234  -14.44666  1.000 17.27962  ? 208 TYR A CE2 1 
ATOM   1152 C  CZ  . TYR A 1 250 ? 41.52127 26.55703  -14.52643  1.000 21.79089  ? 208 TYR A CZ  1 
ATOM   1153 O  OH  . TYR A 1 250 ? 40.79802 27.08188  -13.50095  1.000 23.65582  ? 208 TYR A OH  1 
ATOM   1154 N  N   . ASN A 1 251 ? 44.22524 27.97590  -19.08003  1.000 19.53632  ? 209 ASN A N   1 
ATOM   1155 C  CA  . ASN A 1 251 ? 44.99411 29.21918  -19.03633  1.000 21.57455  ? 209 ASN A CA  1 
ATOM   1156 C  C   . ASN A 1 251 ? 46.15232 29.16824  -20.03271  1.000 21.91392  ? 209 ASN A C   1 
ATOM   1157 O  O   . ASN A 1 251 ? 47.26194 29.58629  -19.72794  1.000 18.47471  ? 209 ASN A O   1 
ATOM   1158 C  CB  . ASN A 1 251 ? 45.51368 29.51285  -17.61780  1.000 19.31813  ? 209 ASN A CB  1 
ATOM   1159 C  CG  . ASN A 1 251 ? 45.91535 30.99588  -17.42892  1.000 33.07018  ? 209 ASN A CG  1 
ATOM   1160 O  OD1 . ASN A 1 251 ? 45.42253 31.87510  -18.13275  1.000 27.49856  ? 209 ASN A OD1 1 
ATOM   1161 N  ND2 . ASN A 1 251 ? 46.82320 31.25929  -16.49694  1.000 27.56497  ? 209 ASN A ND2 1 
ATOM   1162 N  N   . GLY A 1 252 ? 45.90440 28.60646  -21.21734  1.000 19.98063  ? 210 GLY A N   1 
ATOM   1163 C  CA  . GLY A 1 252 ? 46.88790 28.58505  -22.27954  1.000 16.79922  ? 210 GLY A CA  1 
ATOM   1164 C  C   . GLY A 1 252 ? 48.00219 27.56433  -22.12059  1.000 24.10319  ? 210 GLY A C   1 
ATOM   1165 O  O   . GLY A 1 252 ? 48.87604 27.47854  -22.99595  1.000 21.92822  ? 210 GLY A O   1 
ATOM   1166 N  N   . ILE A 1 253 ? 48.01288 26.79015  -21.04254  1.000 25.07382  ? 211 ILE A N   1 
ATOM   1167 C  CA  . ILE A 1 253 ? 49.07181 25.82430  -20.77249  1.000 18.43133  ? 211 ILE A CA  1 
ATOM   1168 C  C   . ILE A 1 253 ? 48.51955 24.41177  -20.97350  1.000 24.22640  ? 211 ILE A C   1 
ATOM   1169 O  O   . ILE A 1 253 ? 47.42318 24.09997  -20.49024  1.000 19.75565  ? 211 ILE A O   1 
ATOM   1170 C  CB  . ILE A 1 253 ? 49.59608 26.00532  -19.34423  1.000 22.01833  ? 211 ILE A CB  1 
ATOM   1171 C  CG1 . ILE A 1 253 ? 50.22964 27.39641  -19.19791  1.000 24.64632  ? 211 ILE A CG1 1 
ATOM   1172 C  CG2 . ILE A 1 253 ? 50.56122 24.87841  -18.98383  1.000 22.72229  ? 211 ILE A CG2 1 
ATOM   1173 C  CD1 . ILE A 1 253 ? 50.04981 27.96079  -17.84437  1.000 28.12614  ? 211 ILE A CD1 1 
ATOM   1174 N  N   . ILE A 1 254 ? 49.27590 23.54693  -21.66583  1.000 21.63926  ? 212 ILE A N   1 
ATOM   1175 C  CA  . ILE A 1 254 ? 48.79859 22.17114  -21.87912  1.000 16.82335  ? 212 ILE A CA  1 
ATOM   1176 C  C   . ILE A 1 254 ? 48.69812 21.43844  -20.55396  1.000 21.15411  ? 212 ILE A C   1 
ATOM   1177 O  O   . ILE A 1 254 ? 49.66100 21.36306  -19.78686  1.000 22.62771  ? 212 ILE A O   1 
ATOM   1178 C  CB  . ILE A 1 254 ? 49.69552 21.40986  -22.86039  1.000 22.21503  ? 212 ILE A CB  1 
ATOM   1179 C  CG1 . ILE A 1 254 ? 49.55094 22.02710  -24.24776  1.000 18.15883  ? 212 ILE A CG1 1 
ATOM   1180 C  CG2 . ILE A 1 254 ? 49.28318 19.89723  -22.89968  1.000 16.86416  ? 212 ILE A CG2 1 
ATOM   1181 C  CD1 . ILE A 1 254 ? 50.44494 21.43179  -25.28454  1.000 24.32687  ? 212 ILE A CD1 1 
ATOM   1182 N  N   . THR A 1 255 ? 47.52517 20.87379  -20.28448  1.000 19.87802  ? 213 THR A N   1 
ATOM   1183 C  CA  . THR A 1 255 ? 47.27886 20.18262  -19.03307  1.000 19.30963  ? 213 THR A CA  1 
ATOM   1184 C  C   . THR A 1 255 ? 46.87970 18.72470  -19.19712  1.000 20.21080  ? 213 THR A C   1 
ATOM   1185 O  O   . THR A 1 255 ? 47.05132 17.96871  -18.24582  1.000 25.70825  ? 213 THR A O   1 
ATOM   1186 C  CB  . THR A 1 255 ? 46.17448 20.89872  -18.24362  1.000 23.09244  ? 213 THR A CB  1 
ATOM   1187 O  OG1 . THR A 1 255 ? 45.07713 21.12097  -19.13018  1.000 20.82261  ? 213 THR A OG1 1 
ATOM   1188 C  CG2 . THR A 1 255 ? 46.68118 22.25629  -17.73824  1.000 24.89672  ? 213 THR A CG2 1 
ATOM   1189 N  N   . ASP A 1 256 ? 46.38094 18.30861  -20.36662  1.000 15.89028  ? 214 ASP A N   1 
ATOM   1190 C  CA  . ASP A 1 256 ? 45.96864 16.93039  -20.59214  1.000 18.95789  ? 214 ASP A CA  1 
ATOM   1191 C  C   . ASP A 1 256 ? 45.83641 16.68371  -22.08621  1.000 21.24107  ? 214 ASP A C   1 
ATOM   1192 O  O   . ASP A 1 256 ? 45.81887 17.61353  -22.89956  1.000 21.47587  ? 214 ASP A O   1 
ATOM   1193 C  CB  . ASP A 1 256 ? 44.64394 16.63577  -19.88860  1.000 21.31174  ? 214 ASP A CB  1 
ATOM   1194 C  CG  . ASP A 1 256 ? 44.61103 15.26880  -19.26852  1.000 26.82255  ? 214 ASP A CG  1 
ATOM   1195 O  OD1 . ASP A 1 256 ? 45.43605 14.41640  -19.68399  1.000 27.40849  ? 214 ASP A OD1 1 
ATOM   1196 O  OD2 . ASP A 1 256 ? 43.77153 15.06904  -18.35484  1.000 27.39581  ? 214 ASP A OD2 1 
ATOM   1197 N  N   . THR A 1 257 ? 45.76149 15.41240  -22.44429  1.000 22.95834  ? 215 THR A N   1 
ATOM   1198 C  CA  . THR A 1 257 ? 45.40365 15.01790  -23.79392  1.000 23.06263  ? 215 THR A CA  1 
ATOM   1199 C  C   . THR A 1 257 ? 44.38320 13.88823  -23.69760  1.000 23.73720  ? 215 THR A C   1 
ATOM   1200 O  O   . THR A 1 257 ? 44.32328 13.17793  -22.69657  1.000 23.75205  ? 215 THR A O   1 
ATOM   1201 C  CB  . THR A 1 257 ? 46.61667 14.55757  -24.59256  1.000 24.80659  ? 215 THR A CB  1 
ATOM   1202 O  OG1 . THR A 1 257 ? 47.15840 13.39408  -23.95607  1.000 24.38938  ? 215 THR A OG1 1 
ATOM   1203 C  CG2 . THR A 1 257 ? 47.72508 15.69265  -24.67499  1.000 18.05883  ? 215 THR A CG2 1 
ATOM   1204 N  N   . ILE A 1 258 ? 43.56185 13.75643  -24.73338  1.000 19.24090  ? 216 ILE A N   1 
ATOM   1205 C  CA  . ILE A 1 258 ? 42.56194 12.70196  -24.86302  1.000 18.10303  ? 216 ILE A CA  1 
ATOM   1206 C  C   . ILE A 1 258 ? 42.70902 12.17156  -26.26930  1.000 20.75456  ? 216 ILE A C   1 
ATOM   1207 O  O   . ILE A 1 258 ? 42.50602 12.92072  -27.22900  1.000 18.62333  ? 216 ILE A O   1 
ATOM   1208 C  CB  . ILE A 1 258 ? 41.12208 13.20561  -24.66002  1.000 13.80617  ? 216 ILE A CB  1 
ATOM   1209 C  CG1 . ILE A 1 258 ? 40.93928 13.81669  -23.27707  1.000 17.96709  ? 216 ILE A CG1 1 
ATOM   1210 C  CG2 . ILE A 1 258 ? 40.08333 12.04934  -24.91386  1.000 17.42058  ? 216 ILE A CG2 1 
ATOM   1211 C  CD1 . ILE A 1 258 ? 39.73674 14.76512  -23.20335  1.000 25.61813  ? 216 ILE A CD1 1 
ATOM   1212 N  N   . LYS A 1 259 ? 43.04290 10.89231  -26.40524  1.000 15.72957  ? 217 LYS A N   1 
ATOM   1213 C  CA  . LYS A 1 259 ? 43.24893 10.32350  -27.72858  1.000 16.80853  ? 217 LYS A CA  1 
ATOM   1214 C  C   . LYS A 1 259 ? 42.02405 9.52392   -28.16232  1.000 17.45843  ? 217 LYS A C   1 
ATOM   1215 O  O   . LYS A 1 259 ? 41.29245 8.96843   -27.33881  1.000 24.29522  ? 217 LYS A O   1 
ATOM   1216 C  CB  . LYS A 1 259 ? 44.50227 9.42988   -27.76161  1.000 19.79360  ? 217 LYS A CB  1 
ATOM   1217 C  CG  . LYS A 1 259 ? 44.91276 9.02324   -29.16919  1.000 19.37095  ? 217 LYS A CG  1 
ATOM   1218 C  CD  . LYS A 1 259 ? 46.34842 8.51644   -29.26674  1.000 22.59735  ? 217 LYS A CD  1 
ATOM   1219 C  CE  . LYS A 1 259 ? 46.70338 8.21361   -30.70723  1.000 25.04963  ? 217 LYS A CE  1 
ATOM   1220 N  NZ  . LYS A 1 259 ? 48.13854 7.74659   -30.82709  1.000 30.79001  ? 217 LYS A NZ  1 
ATOM   1221 N  N   . SER A 1 260 ? 41.80447 9.50550   -29.47071  1.000 16.41705  ? 218 SER A N   1 
ATOM   1222 C  CA  . SER A 1 260 ? 40.74502 8.76032   -30.13675  1.000 18.64889  ? 218 SER A CA  1 
ATOM   1223 C  C   . SER A 1 260 ? 40.72100 7.31114   -29.65423  1.000 23.09278  ? 218 SER A C   1 
ATOM   1224 O  O   . SER A 1 260 ? 41.73443 6.62533   -29.69964  1.000 22.99176  ? 218 SER A O   1 
ATOM   1225 C  CB  . SER A 1 260 ? 41.04355 8.85120   -31.62802  1.000 16.80634  ? 218 SER A CB  1 
ATOM   1226 O  OG  . SER A 1 260 ? 40.18334 8.13558   -32.48383  1.000 19.63836  ? 218 SER A OG  1 
ATOM   1227 N  N   . TRP A 1 261 ? 39.57899 6.84651   -29.16122  1.000 24.53121  ? 219 TRP A N   1 
ATOM   1228 C  CA  . TRP A 1 261 ? 39.47091 5.48560   -28.64172  1.000 21.41369  ? 219 TRP A CA  1 
ATOM   1229 C  C   . TRP A 1 261 ? 38.81795 4.52830   -29.62912  1.000 26.84283  ? 219 TRP A C   1 
ATOM   1230 O  O   . TRP A 1 261 ? 38.75923 3.31362   -29.36710  1.000 23.11086  ? 219 TRP A O   1 
ATOM   1231 C  CB  . TRP A 1 261 ? 38.71046 5.48579   -27.31306  1.000 16.96610  ? 219 TRP A CB  1 
ATOM   1232 C  CG  . TRP A 1 261 ? 37.27503 5.87701   -27.45663  1.000 22.07260  ? 219 TRP A CG  1 
ATOM   1233 C  CD1 . TRP A 1 261 ? 36.22772 5.05200   -27.65699  1.000 23.13573  ? 219 TRP A CD1 1 
ATOM   1234 C  CD2 . TRP A 1 261 ? 36.73988 7.21004   -27.41784  1.000 25.22523  ? 219 TRP A CD2 1 
ATOM   1235 N  NE1 . TRP A 1 261 ? 35.06029 5.78008   -27.74215  1.000 29.84583  ? 219 TRP A NE1 1 
ATOM   1236 C  CE2 . TRP A 1 261 ? 35.34958 7.10666   -27.61041  1.000 25.46669  ? 219 TRP A CE2 1 
ATOM   1237 C  CE3 . TRP A 1 261 ? 37.30684 8.47941   -27.24687  1.000 26.70804  ? 219 TRP A CE3 1 
ATOM   1238 C  CZ2 . TRP A 1 261 ? 34.50882 8.21721   -27.61934  1.000 26.27125  ? 219 TRP A CZ2 1 
ATOM   1239 C  CZ3 . TRP A 1 261 ? 36.47444 9.57518   -27.23528  1.000 25.23364  ? 219 TRP A CZ3 1 
ATOM   1240 C  CH2 . TRP A 1 261 ? 35.08818 9.44419   -27.43042  1.000 29.71360  ? 219 TRP A CH2 1 
ATOM   1241 N  N   . ARG A 1 262 ? 38.37014 5.03528   -30.77395  1.000 20.97631  ? 220 ARG A N   1 
ATOM   1242 C  CA  . ARG A 1 262 ? 37.85961 4.19948   -31.84384  1.000 16.96742  ? 220 ARG A CA  1 
ATOM   1243 C  C   . ARG A 1 262 ? 38.58422 4.40665   -33.15467  1.000 23.53816  ? 220 ARG A C   1 
ATOM   1244 O  O   . ARG A 1 262 ? 38.20856 3.75628   -34.14238  1.000 20.10024  ? 220 ARG A O   1 
ATOM   1245 C  CB  . ARG A 1 262 ? 36.35091 4.44160   -32.08793  1.000 23.82070  ? 220 ARG A CB  1 
ATOM   1246 C  CG  . ARG A 1 262 ? 35.52825 4.09371   -30.87696  1.000 32.42815  ? 220 ARG A CG  1 
ATOM   1247 C  CD  . ARG A 1 262 ? 35.32731 2.59373   -30.75291  1.000 35.68117  ? 220 ARG A CD  1 
ATOM   1248 N  NE  . ARG A 1 262 ? 34.01512 2.11509   -31.15468  1.000 55.10352  ? 220 ARG A NE  1 
ATOM   1249 C  CZ  . ARG A 1 262 ? 33.07813 1.84542   -30.23867  1.000 76.52635  ? 220 ARG A CZ  1 
ATOM   1250 N  NH1 . ARG A 1 262 ? 33.33033 1.98596   -28.92542  1.000 73.71623  ? 220 ARG A NH1 1 
ATOM   1251 N  NH2 . ARG A 1 262 ? 31.89301 1.33338   -30.62356  1.000 77.39013  ? 220 ARG A NH2 1 
ATOM   1252 N  N   . ASN A 1 263 ? 39.55587 5.33995   -33.22399  1.000 17.98727  ? 221 ASN A N   1 
ATOM   1253 C  CA  . ASN A 1 263 ? 40.32541 5.54935   -34.44980  1.000 15.60812  ? 221 ASN A CA  1 
ATOM   1254 C  C   . ASN A 1 263 ? 39.43492 5.97084   -35.59938  1.000 14.42111  ? 221 ASN A C   1 
ATOM   1255 O  O   . ASN A 1 263 ? 39.68873 5.63581   -36.75896  1.000 17.09474  ? 221 ASN A O   1 
ATOM   1256 C  CB  . ASN A 1 263 ? 41.13316 4.29756   -34.84008  1.000 19.02649  ? 221 ASN A CB  1 
ATOM   1257 C  CG  . ASN A 1 263 ? 42.08776 3.86702   -33.75815  1.000 25.13323  ? 221 ASN A CG  1 
ATOM   1258 O  OD1 . ASN A 1 263 ? 42.18826 4.50526   -32.71422  1.000 25.99622  ? 221 ASN A OD1 1 
ATOM   1259 N  ND2 . ASN A 1 263 ? 42.82012 2.79169   -34.01230  1.000 42.61215  ? 221 ASN A ND2 1 
ATOM   1260 N  N   . ASN A 1 264 ? 38.43265 6.79227   -35.30625  1.000 17.19725  ? 222 ASN A N   1 
ATOM   1261 C  CA  . ASN A 1 264 ? 37.55889 7.15983   -36.39683  1.000 17.42186  ? 222 ASN A CA  1 
ATOM   1262 C  C   . ASN A 1 264 ? 37.02103 8.57868   -36.16668  1.000 21.93198  ? 222 ASN A C   1 
ATOM   1263 O  O   . ASN A 1 264 ? 35.84022 8.77690   -35.89460  1.000 18.15636  ? 222 ASN A O   1 
ATOM   1264 C  CB  . ASN A 1 264 ? 36.43989 6.11886   -36.53200  1.000 16.85265  ? 222 ASN A CB  1 
ATOM   1265 C  CG  . ASN A 1 264 ? 35.65714 6.29018   -37.79333  1.000 23.69216  ? 222 ASN A CG  1 
ATOM   1266 O  OD1 . ASN A 1 264 ? 35.99123 7.13278   -38.61641  1.000 21.48443  ? 222 ASN A OD1 1 
ATOM   1267 N  ND2 . ASN A 1 264 ? 34.57439 5.52167   -37.94423  1.000 23.62751  ? 222 ASN A ND2 1 
ATOM   1268 N  N   . ILE A 1 265 ? 37.91568 9.56977   -36.29978  1.000 19.97174  ? 223 ILE A N   1 
ATOM   1269 C  CA  . ILE A 1 265 ? 37.60608 11.00042  -36.24622  1.000 15.34652  ? 223 ILE A CA  1 
ATOM   1270 C  C   . ILE A 1 265 ? 37.01276 11.39444  -34.89585  1.000 14.31678  ? 223 ILE A C   1 
ATOM   1271 O  O   . ILE A 1 265 ? 35.81866 11.74054  -34.79530  1.000 14.01078  ? 223 ILE A O   1 
ATOM   1272 C  CB  . ILE A 1 265 ? 36.67622 11.42387  -37.39974  1.000 21.41550  ? 223 ILE A CB  1 
ATOM   1273 C  CG1 . ILE A 1 265 ? 37.19266 10.86201  -38.71709  1.000 24.04884  ? 223 ILE A CG1 1 
ATOM   1274 C  CG2 . ILE A 1 265 ? 36.56480 13.00722  -37.52545  1.000 14.22535  ? 223 ILE A CG2 1 
ATOM   1275 C  CD1 . ILE A 1 265 ? 36.28730 11.19877  -39.87587  1.000 25.98251  ? 223 ILE A CD1 1 
ATOM   1276 N  N   . LEU A 1 266 ? 37.84019 11.34578  -33.85157  1.000 14.67108  ? 224 LEU A N   1 
ATOM   1277 C  CA  . LEU A 1 266 ? 37.50792 11.98389  -32.58084  1.000 17.05068  ? 224 LEU A CA  1 
ATOM   1278 C  C   . LEU A 1 266 ? 37.09195 13.44653  -32.81854  1.000 17.35080  ? 224 LEU A C   1 
ATOM   1279 O  O   . LEU A 1 266 ? 37.74345 14.15762  -33.57714  1.000 16.48830  ? 224 LEU A O   1 
ATOM   1280 C  CB  . LEU A 1 266 ? 38.72599 11.92982  -31.65334  1.000 13.84225  ? 224 LEU A CB  1 
ATOM   1281 C  CG  . LEU A 1 266 ? 38.53227 12.55717  -30.26758  1.000 19.56335  ? 224 LEU A CG  1 
ATOM   1282 C  CD1 . LEU A 1 266 ? 37.52449 11.76796  -29.47498  1.000 16.93584  ? 224 LEU A CD1 1 
ATOM   1283 C  CD2 . LEU A 1 266 ? 39.82055 12.56736  -29.52495  1.000 20.57519  ? 224 LEU A CD2 1 
ATOM   1284 N  N   . ARG A 1 267 ? 35.99042 13.88046  -32.20628  1.000 16.10271  ? 225 ARG A N   1 
ATOM   1285 C  CA  . ARG A 1 267 ? 35.42816 15.19632  -32.53841  1.000 15.05030  ? 225 ARG A CA  1 
ATOM   1286 C  C   . ARG A 1 267 ? 34.48081 15.63654  -31.43573  1.000 18.18099  ? 225 ARG A C   1 
ATOM   1287 O  O   . ARG A 1 267 ? 33.85035 14.81144  -30.76965  1.000 19.41100  ? 225 ARG A O   1 
ATOM   1288 C  CB  . ARG A 1 267 ? 34.70514 15.18665  -33.89417  1.000 16.36551  ? 225 ARG A CB  1 
ATOM   1289 C  CG  . ARG A 1 267 ? 33.58895 14.09026  -33.98635  1.000 15.81236  ? 225 ARG A CG  1 
ATOM   1290 C  CD  . ARG A 1 267 ? 33.26998 13.83913  -35.43354  1.000 15.47186  ? 225 ARG A CD  1 
ATOM   1291 N  NE  . ARG A 1 267 ? 32.13778 12.95864  -35.64452  1.000 20.91743  ? 225 ARG A NE  1 
ATOM   1292 C  CZ  . ARG A 1 267 ? 32.19528 11.63568  -35.77924  1.000 19.44531  ? 225 ARG A CZ  1 
ATOM   1293 N  NH1 . ARG A 1 267 ? 33.35137 10.95935  -35.68110  1.000 14.62351  ? 225 ARG A NH1 1 
ATOM   1294 N  NH2 . ARG A 1 267 ? 31.05954 10.96668  -35.98952  1.000 18.01697  ? 225 ARG A NH2 1 
ATOM   1295 N  N   . THR A 1 268 ? 34.35882 16.95240  -31.26836  1.000 17.78852  ? 226 THR A N   1 
ATOM   1296 C  CA  . THR A 1 268 ? 33.65221 17.43139  -30.09208  1.000 16.25933  ? 226 THR A CA  1 
ATOM   1297 C  C   . THR A 1 268 ? 32.68076 18.55618  -30.44911  1.000 19.49916  ? 226 THR A C   1 
ATOM   1298 O  O   . THR A 1 268 ? 32.20679 18.57520  -31.59663  1.000 18.51596  ? 226 THR A O   1 
ATOM   1299 C  CB  . THR A 1 268 ? 34.68935 17.79762  -29.01763  1.000 12.58063  ? 226 THR A CB  1 
ATOM   1300 O  OG1 . THR A 1 268 ? 34.01907 18.15954  -27.80862  1.000 18.55758  ? 226 THR A OG1 1 
ATOM   1301 C  CG2 . THR A 1 268 ? 35.69117 18.92668  -29.47254  1.000 11.80847  ? 226 THR A CG2 1 
ATOM   1302 N  N   . GLN A 1 269 ? 32.39585 19.48625  -29.49918  1.000 15.73324  ? 227 GLN A N   1 
ATOM   1303 C  CA  . GLN A 1 269 ? 31.15473 20.28339  -29.52685  1.000 18.39139  ? 227 GLN A CA  1 
ATOM   1304 C  C   . GLN A 1 269 ? 31.10090 21.30078  -30.65732  1.000 19.39682  ? 227 GLN A C   1 
ATOM   1305 O  O   . GLN A 1 269 ? 30.04492 21.48974  -31.27216  1.000 20.14681  ? 227 GLN A O   1 
ATOM   1306 C  CB  . GLN A 1 269 ? 30.95651 21.04135  -28.21139  1.000 15.82445  ? 227 GLN A CB  1 
ATOM   1307 C  CG  . GLN A 1 269 ? 30.64674 20.16870  -27.03737  1.000 16.60898  ? 227 GLN A CG  1 
ATOM   1308 C  CD  . GLN A 1 269 ? 30.51963 20.99910  -25.79884  1.000 25.99877  ? 227 GLN A CD  1 
ATOM   1309 O  OE1 . GLN A 1 269 ? 31.34223 20.89919  -24.88564  1.000 23.95821  ? 227 GLN A OE1 1 
ATOM   1310 N  NE2 . GLN A 1 269 ? 29.49345 21.86330  -25.76420  1.000 22.05526  ? 227 GLN A NE2 1 
ATOM   1311 N  N   . GLU A 1 270 ? 32.19685 22.01320  -30.91111  1.000 16.18802  ? 228 GLU A N   1 
ATOM   1312 C  CA  . GLU A 1 270 ? 32.19096 23.21558  -31.75739  1.000 13.90906  ? 228 GLU A CA  1 
ATOM   1313 C  C   . GLU A 1 270 ? 31.32490 24.32689  -31.17217  1.000 16.51369  ? 228 GLU A C   1 
ATOM   1314 O  O   . GLU A 1 270 ? 30.76631 25.13863  -31.90697  1.000 16.55774  ? 228 GLU A O   1 
ATOM   1315 C  CB  . GLU A 1 270 ? 31.74816 22.90752  -33.19197  1.000 15.40889  ? 228 GLU A CB  1 
ATOM   1316 C  CG  . GLU A 1 270 ? 32.04362 21.46353  -33.69808  1.000 15.75108  ? 228 GLU A CG  1 
ATOM   1317 C  CD  . GLU A 1 270 ? 33.51501 21.13693  -33.83357  1.000 23.82833  ? 228 GLU A CD  1 
ATOM   1318 O  OE1 . GLU A 1 270 ? 34.36509 21.93988  -33.41764  1.000 20.91404  ? 228 GLU A OE1 1 
ATOM   1319 O  OE2 . GLU A 1 270 ? 33.83276 20.05845  -34.36550  1.000 25.00960  ? 228 GLU A OE2 1 
ATOM   1320 N  N   . SER A 1 271 ? 31.19715 24.34223  -29.84888  1.000 15.70224  ? 229 SER A N   1 
ATOM   1321 C  CA  . SER A 1 271 ? 30.61455 25.42632  -29.07398  1.000 12.07117  ? 229 SER A CA  1 
ATOM   1322 C  C   . SER A 1 271 ? 31.12100 25.22944  -27.65055  1.000 16.35553  ? 229 SER A C   1 
ATOM   1323 O  O   . SER A 1 271 ? 31.86699 24.29827  -27.37156  1.000 17.93401  ? 229 SER A O   1 
ATOM   1324 C  CB  . SER A 1 271 ? 29.06424 25.44405  -29.13934  1.000 18.08620  ? 229 SER A CB  1 
ATOM   1325 O  OG  . SER A 1 271 ? 28.48329 24.29422  -28.50757  1.000 19.79571  ? 229 SER A OG  1 
ATOM   1326 N  N   . GLU A 1 272 ? 30.70312 26.08826  -26.73680  1.000 19.70852  ? 230 GLU A N   1 
ATOM   1327 C  CA  . GLU A 1 272 ? 31.33588 26.10267  -25.42300  1.000 18.34707  ? 230 GLU A CA  1 
ATOM   1328 C  C   . GLU A 1 272 ? 31.01078 24.86938  -24.58777  1.000 18.85315  ? 230 GLU A C   1 
ATOM   1329 O  O   . GLU A 1 272 ? 29.93149 24.27452  -24.70828  1.000 17.28982  ? 230 GLU A O   1 
ATOM   1330 C  CB  . GLU A 1 272 ? 30.93318 27.35410  -24.66296  1.000 14.72242  ? 230 GLU A CB  1 
ATOM   1331 C  CG  . GLU A 1 272 ? 29.49400 27.39168  -24.25070  1.000 18.58501  ? 230 GLU A CG  1 
ATOM   1332 C  CD  . GLU A 1 272 ? 29.24831 28.50468  -23.24936  1.000 26.98597  ? 230 GLU A CD  1 
ATOM   1333 O  OE1 . GLU A 1 272 ? 30.17218 29.38708  -23.04556  1.000 16.18216  ? 230 GLU A OE1 1 
ATOM   1334 O  OE2 . GLU A 1 272 ? 28.13414 28.47429  -22.66618  1.000 18.71423  ? 230 GLU A OE2 1 
ATOM   1335 N  N   . CYS A 1 273 ? 31.97587 24.46293  -23.74972  1.000 13.86755  ? 231 CYS A N   1 
ATOM   1336 C  CA  . CYS A 1 273 ? 31.69937 23.47275  -22.71823  1.000 19.51355  ? 231 CYS A CA  1 
ATOM   1337 C  C   . CYS A 1 273 ? 30.91848 24.14833  -21.58908  1.000 25.38560  ? 231 CYS A C   1 
ATOM   1338 O  O   . CYS A 1 273 ? 30.63002 25.34698  -21.63811  1.000 23.50943  ? 231 CYS A O   1 
ATOM   1339 C  CB  . CYS A 1 273 ? 32.98470 22.80324  -22.22211  1.000 16.99387  ? 231 CYS A CB  1 
ATOM   1340 S  SG  . CYS A 1 273 ? 34.52017 23.74904  -22.35166  1.000 22.80169  ? 231 CYS A SG  1 
ATOM   1341 N  N   . ALA A 1 274 ? 30.53564 23.38204  -20.56944  1.000 18.14333  ? 232 ALA A N   1 
ATOM   1342 C  CA  . ALA A 1 274 ? 29.70591 23.89309  -19.47965  1.000 16.38596  ? 232 ALA A CA  1 
ATOM   1343 C  C   . ALA A 1 274 ? 30.46711 23.73518  -18.17218  1.000 21.32320  ? 232 ALA A C   1 
ATOM   1344 O  O   . ALA A 1 274 ? 31.03553 22.66726  -17.91324  1.000 23.46133  ? 232 ALA A O   1 
ATOM   1345 C  CB  . ALA A 1 274 ? 28.36871 23.14246  -19.41013  1.000 21.98993  ? 232 ALA A CB  1 
ATOM   1346 N  N   . CYS A 1 275 ? 30.51015 24.79574  -17.36106  1.000 22.99121  ? 233 CYS A N   1 
ATOM   1347 C  CA  . CYS A 1 275 ? 31.23457 24.75745  -16.09476  1.000 22.78920  ? 233 CYS A CA  1 
ATOM   1348 C  C   . CYS A 1 275 ? 30.28551 24.92164  -14.90967  1.000 21.81803  ? 233 CYS A C   1 
ATOM   1349 O  O   . CYS A 1 275 ? 29.41580 25.81262  -14.89644  1.000 25.02485  ? 233 CYS A O   1 
ATOM   1350 C  CB  . CYS A 1 275 ? 32.34901 25.83531  -16.04754  1.000 23.65011  ? 233 CYS A CB  1 
ATOM   1351 S  SG  . CYS A 1 275 ? 33.67971 25.57075  -17.29713  1.000 29.37275  ? 233 CYS A SG  1 
ATOM   1352 N  N   . VAL A 1 276 ? 30.49315 24.07848  -13.89664  1.000 20.26620  ? 234 VAL A N   1 
ATOM   1353 C  CA  . VAL A 1 276 ? 29.70980 24.07436  -12.65756  1.000 29.42814  ? 234 VAL A CA  1 
ATOM   1354 C  C   . VAL A 1 276 ? 30.66835 23.83634  -11.49422  1.000 23.72321  ? 234 VAL A C   1 
ATOM   1355 O  O   . VAL A 1 276 ? 31.23277 22.74297  -11.36639  1.000 25.58201  ? 234 VAL A O   1 
ATOM   1356 C  CB  . VAL A 1 276 ? 28.59859 23.00211  -12.65194  1.000 25.30026  ? 234 VAL A CB  1 
ATOM   1357 C  CG1 . VAL A 1 276 ? 27.91334 22.96115  -11.28712  1.000 26.97259  ? 234 VAL A CG1 1 
ATOM   1358 C  CG2 . VAL A 1 276 ? 27.57393 23.27060  -13.72275  1.000 22.34105  ? 234 VAL A CG2 1 
ATOM   1359 N  N   . ASN A 1 277 ? 30.83104 24.84385  -10.63414  1.000 24.33602  ? 235 ASN A N   1 
ATOM   1360 C  CA  . ASN A 1 277 ? 31.55424 24.69228  -9.37089   1.000 30.59178  ? 235 ASN A CA  1 
ATOM   1361 C  C   . ASN A 1 277 ? 32.98828 24.21097  -9.60148   1.000 31.94268  ? 235 ASN A C   1 
ATOM   1362 O  O   . ASN A 1 277 ? 33.51288 23.38063  -8.85886   1.000 28.01490  ? 235 ASN A O   1 
ATOM   1363 C  CB  . ASN A 1 277 ? 30.80097 23.74986  -8.41256   1.000 27.36414  ? 235 ASN A CB  1 
ATOM   1364 C  CG  . ASN A 1 277 ? 31.36706 23.77873  -6.99993   1.000 32.52954  ? 235 ASN A CG  1 
ATOM   1365 O  OD1 . ASN A 1 277 ? 31.85428 24.82006  -6.54723   1.000 34.42745  ? 235 ASN A OD1 1 
ATOM   1366 N  ND2 . ASN A 1 277 ? 31.34117 22.63405  -6.31097   1.000 36.37229  ? 235 ASN A ND2 1 
ATOM   1367 N  N   . GLY A 1 278 ? 33.63030 24.70992  -10.65063  1.000 25.28643  ? 236 GLY A N   1 
ATOM   1368 C  CA  . GLY A 1 278 ? 35.03047 24.36528  -10.85323  1.000 32.67756  ? 236 GLY A CA  1 
ATOM   1369 C  C   . GLY A 1 278 ? 35.28362 23.12791  -11.69047  1.000 29.66194  ? 236 GLY A C   1 
ATOM   1370 O  O   . GLY A 1 278 ? 36.44863 22.80931  -11.96670  1.000 27.61605  ? 236 GLY A O   1 
ATOM   1371 N  N   . SER A 1 279 ? 34.23735 22.41260  -12.09523  1.000 27.92455  ? 237 SER A N   1 
ATOM   1372 C  CA  . SER A 1 279 ? 34.36122 21.32071  -13.04699  1.000 19.71150  ? 237 SER A CA  1 
ATOM   1373 C  C   . SER A 1 279 ? 33.70088 21.71974  -14.35663  1.000 23.71319  ? 237 SER A C   1 
ATOM   1374 O  O   . SER A 1 279 ? 32.62280 22.33311  -14.36951  1.000 24.99438  ? 237 SER A O   1 
ATOM   1375 C  CB  . SER A 1 279 ? 33.74275 20.03764  -12.51734  1.000 23.46816  ? 237 SER A CB  1 
ATOM   1376 O  OG  . SER A 1 279 ? 34.04223 19.90153  -11.14591  1.000 31.31959  ? 237 SER A OG  1 
ATOM   1377 N  N   . CYS A 1 280 ? 34.37280 21.40156  -15.45635  1.000 20.13058  ? 238 CYS A N   1 
ATOM   1378 C  CA  . CYS A 1 280 ? 33.87541 21.69449  -16.78372  1.000 18.99650  ? 238 CYS A CA  1 
ATOM   1379 C  C   . CYS A 1 280 ? 33.62918 20.39069  -17.52915  1.000 22.02470  ? 238 CYS A C   1 
ATOM   1380 O  O   . CYS A 1 280 ? 34.31544 19.37800  -17.31042  1.000 16.92152  ? 238 CYS A O   1 
ATOM   1381 C  CB  . CYS A 1 280 ? 34.85490 22.61410  -17.52423  1.000 23.44270  ? 238 CYS A CB  1 
ATOM   1382 S  SG  . CYS A 1 280 ? 35.08735 24.18400  -16.55760  1.000 28.10714  ? 238 CYS A SG  1 
ATOM   1383 N  N   . PHE A 1 281 ? 32.62912 20.43036  -18.40216  1.000 20.94129  ? 239 PHE A N   1 
ATOM   1384 C  CA  . PHE A 1 281 ? 32.04630 19.23045  -18.97331  1.000 18.69451  ? 239 PHE A CA  1 
ATOM   1385 C  C   . PHE A 1 281 ? 31.91404 19.39717  -20.48373  1.000 21.70547  ? 239 PHE A C   1 
ATOM   1386 O  O   . PHE A 1 281 ? 31.49904 20.45269  -20.97817  1.000 18.93029  ? 239 PHE A O   1 
ATOM   1387 C  CB  . PHE A 1 281 ? 30.67935 18.94827  -18.34670  1.000 18.83966  ? 239 PHE A CB  1 
ATOM   1388 C  CG  . PHE A 1 281 ? 30.69959 18.76486  -16.83928  1.000 20.38025  ? 239 PHE A CG  1 
ATOM   1389 C  CD1 . PHE A 1 281 ? 30.53886 19.85311  -15.98882  1.000 18.36191  ? 239 PHE A CD1 1 
ATOM   1390 C  CD2 . PHE A 1 281 ? 30.84859 17.47570  -16.27184  1.000 18.83147  ? 239 PHE A CD2 1 
ATOM   1391 C  CE1 . PHE A 1 281 ? 30.53704 19.70126  -14.60983  1.000 15.36519  ? 239 PHE A CE1 1 
ATOM   1392 C  CE2 . PHE A 1 281 ? 30.82742 17.31149  -14.88574  1.000 15.89601  ? 239 PHE A CE2 1 
ATOM   1393 C  CZ  . PHE A 1 281 ? 30.67973 18.41558  -14.05061  1.000 19.88829  ? 239 PHE A CZ  1 
ATOM   1394 N  N   . THR A 1 282 ? 32.24780 18.34721  -21.21378  1.000 18.09388  ? 240 THR A N   1 
ATOM   1395 C  CA  . THR A 1 282 ? 32.09056 18.35859  -22.65687  1.000 17.31385  ? 240 THR A CA  1 
ATOM   1396 C  C   . THR A 1 282 ? 31.70635 16.95551  -23.09022  1.000 19.03436  ? 240 THR A C   1 
ATOM   1397 O  O   . THR A 1 282 ? 31.74293 16.00975  -22.30593  1.000 20.62366  ? 240 THR A O   1 
ATOM   1398 C  CB  . THR A 1 282 ? 33.36568 18.83982  -23.37954  1.000 20.15416  ? 240 THR A CB  1 
ATOM   1399 O  OG1 . THR A 1 282 ? 33.06603 19.05514  -24.76375  1.000 23.71897  ? 240 THR A OG1 1 
ATOM   1400 C  CG2 . THR A 1 282 ? 34.52932 17.82281  -23.26825  1.000 15.87067  ? 240 THR A CG2 1 
ATOM   1401 N  N   . VAL A 1 283 ? 31.31958 16.83489  -24.34822  1.000 21.41733  ? 241 VAL A N   1 
ATOM   1402 C  CA  . VAL A 1 283 ? 30.95791 15.56048  -24.94319  1.000 18.76346  ? 241 VAL A CA  1 
ATOM   1403 C  C   . VAL A 1 283 ? 31.81717 15.37831  -26.17497  1.000 19.52636  ? 241 VAL A C   1 
ATOM   1404 O  O   . VAL A 1 283 ? 31.99203 16.32637  -26.94191  1.000 19.99250  ? 241 VAL A O   1 
ATOM   1405 C  CB  . VAL A 1 283 ? 29.46221 15.49085  -25.31574  1.000 19.72082  ? 241 VAL A CB  1 
ATOM   1406 C  CG1 . VAL A 1 283 ? 29.16673 14.13795  -25.94520  1.000 17.72258  ? 241 VAL A CG1 1 
ATOM   1407 C  CG2 . VAL A 1 283 ? 28.59122 15.67868  -24.07447  1.000 19.62803  ? 241 VAL A CG2 1 
ATOM   1408 N  N   . MET A 1 284 ? 32.35051 14.16363  -26.37520  1.000 18.51776  ? 242 MET A N   1 
ATOM   1409 C  CA  . MET A 1 284 ? 33.05427 13.84109  -27.61098  1.000 20.19616  ? 242 MET A CA  1 
ATOM   1410 C  C   . MET A 1 284 ? 32.51641 12.54486  -28.19755  1.000 16.43000  ? 242 MET A C   1 
ATOM   1411 O  O   . MET A 1 284 ? 31.99388 11.67950  -27.49136  1.000 19.35979  ? 242 MET A O   1 
ATOM   1412 C  CB  . MET A 1 284 ? 34.58319 13.71643  -27.41671  1.000 14.28748  ? 242 MET A CB  1 
ATOM   1413 C  CG  . MET A 1 284 ? 35.17046 14.91340  -26.75195  1.000 21.52223  ? 242 MET A CG  1 
ATOM   1414 S  SD  . MET A 1 284 ? 36.99515 14.83794  -26.74237  1.000 22.94063  ? 242 MET A SD  1 
ATOM   1415 C  CE  . MET A 1 284 ? 37.34187 16.25740  -25.68342  1.000 24.12309  ? 242 MET A CE  1 
ATOM   1416 N  N   . THR A 1 285 ? 32.68935 12.42140  -29.51487  1.000 14.69459  ? 243 THR A N   1 
ATOM   1417 C  CA  . THR A 1 285 ? 32.20402 11.29890  -30.30023  1.000 20.41158  ? 243 THR A CA  1 
ATOM   1418 C  C   . THR A 1 285 ? 33.38156 10.72320  -31.06275  1.000 20.35493  ? 243 THR A C   1 
ATOM   1419 O  O   . THR A 1 285 ? 34.27876 11.46180  -31.47551  1.000 19.12913  ? 243 THR A O   1 
ATOM   1420 C  CB  . THR A 1 285 ? 31.09701 11.75932  -31.26891  1.000 18.71124  ? 243 THR A CB  1 
ATOM   1421 O  OG1 . THR A 1 285 ? 30.00306 12.29590  -30.50264  1.000 17.37699  ? 243 THR A OG1 1 
ATOM   1422 C  CG2 . THR A 1 285 ? 30.60611 10.62620  -32.17662  1.000 14.79307  ? 243 THR A CG2 1 
ATOM   1423 N  N   . ASP A 1 286 ? 33.38976 9.40758   -31.23351  1.000 15.67303  ? 244 ASP A N   1 
ATOM   1424 C  CA  . ASP A 1 286 ? 34.41867 8.75559   -32.03155  1.000 15.48333  ? 244 ASP A CA  1 
ATOM   1425 C  C   . ASP A 1 286 ? 33.73436 7.62146   -32.78154  1.000 27.01691  ? 244 ASP A C   1 
ATOM   1426 O  O   . ASP A 1 286 ? 33.02624 6.80955   -32.17445  1.000 18.24899  ? 244 ASP A O   1 
ATOM   1427 C  CB  . ASP A 1 286 ? 35.53167 8.26567   -31.11597  1.000 16.31676  ? 244 ASP A CB  1 
ATOM   1428 C  CG  . ASP A 1 286 ? 36.81962 7.95952   -31.86435  1.000 19.91442  ? 244 ASP A CG  1 
ATOM   1429 O  OD1 . ASP A 1 286 ? 36.80866 7.78726   -33.10202  1.000 17.90058  ? 244 ASP A OD1 1 
ATOM   1430 O  OD2 . ASP A 1 286 ? 37.85121 7.89156   -31.19105  1.000 20.58967  ? 244 ASP A OD2 1 
ATOM   1431 N  N   . GLY A 1 287 ? 33.87426 7.60143   -34.09701  1.000 21.76312  ? 245 GLY A N   1 
ATOM   1432 C  CA  . GLY A 1 287 ? 33.12710 6.64979   -34.87228  1.000 16.45424  ? 245 GLY A CA  1 
ATOM   1433 C  C   . GLY A 1 287 ? 32.43002 7.20995   -36.09622  1.000 18.54277  ? 245 GLY A C   1 
ATOM   1434 O  O   . GLY A 1 287 ? 32.59978 8.37810   -36.49646  1.000 18.62242  ? 245 GLY A O   1 
ATOM   1435 N  N   . PRO A 1 288 ? 31.61590 6.34625   -36.71103  1.000 26.81482  ? 246 PRO A N   1 
ATOM   1436 C  CA  . PRO A 1 288 ? 30.89202 6.70966   -37.93650  1.000 18.74101  ? 246 PRO A CA  1 
ATOM   1437 C  C   . PRO A 1 288 ? 30.03352 7.95840   -37.76730  1.000 15.54131  ? 246 PRO A C   1 
ATOM   1438 O  O   . PRO A 1 288 ? 29.52993 8.26033   -36.68450  1.000 14.14310  ? 246 PRO A O   1 
ATOM   1439 C  CB  . PRO A 1 288 ? 30.01345 5.46903   -38.19004  1.000 18.17549  ? 246 PRO A CB  1 
ATOM   1440 C  CG  . PRO A 1 288 ? 30.73832 4.36972   -37.54086  1.000 22.56399  ? 246 PRO A CG  1 
ATOM   1441 C  CD  . PRO A 1 288 ? 31.38224 4.93773   -36.32773  1.000 22.17045  ? 246 PRO A CD  1 
ATOM   1442 N  N   . SER A 1 289 ? 29.87084 8.69835   -38.85496  1.000 18.52017  ? 247 SER A N   1 
ATOM   1443 C  CA  . SER A 1 289 ? 28.90065 9.78852   -38.85437  1.000 27.73780  ? 247 SER A CA  1 
ATOM   1444 C  C   . SER A 1 289 ? 27.60162 9.38791   -39.53575  1.000 24.07578  ? 247 SER A C   1 
ATOM   1445 O  O   . SER A 1 289 ? 26.65632 10.15727  -39.52049  1.000 26.25300  ? 247 SER A O   1 
ATOM   1446 C  CB  . SER A 1 289 ? 29.47699 11.04244  -39.52283  1.000 27.62282  ? 247 SER A CB  1 
ATOM   1447 O  OG  . SER A 1 289 ? 29.85948 10.71876  -40.83414  1.000 33.62751  ? 247 SER A OG  1 
ATOM   1448 N  N   . ASN A 1 290 ? 27.53520 8.18050   -40.09333  1.000 22.30418  ? 248 ASN A N   1 
ATOM   1449 C  CA  . ASN A 1 290 ? 26.36673 7.66840   -40.78416  1.000 20.69538  ? 248 ASN A CA  1 
ATOM   1450 C  C   . ASN A 1 290 ? 25.94040 6.34299   -40.16211  1.000 22.71837  ? 248 ASN A C   1 
ATOM   1451 O  O   . ASN A 1 290 ? 25.43583 5.45595   -40.84987  1.000 24.90116  ? 248 ASN A O   1 
ATOM   1452 C  CB  . ASN A 1 290 ? 26.67638 7.51132   -42.27546  1.000 20.45908  ? 248 ASN A CB  1 
ATOM   1453 C  CG  . ASN A 1 290 ? 27.76426 6.46407   -42.53429  1.000 25.99122  ? 248 ASN A CG  1 
ATOM   1454 O  OD1 . ASN A 1 290 ? 28.47354 6.05498   -41.61955  1.000 18.70963  ? 248 ASN A OD1 1 
ATOM   1455 N  ND2 . ASN A 1 290 ? 27.85898 5.99700   -43.76216  1.000 30.97958  ? 248 ASN A ND2 1 
ATOM   1456 N  N   . GLY A 1 291 ? 26.18743 6.17440   -38.86735  1.000 16.37882  ? 249 GLY A N   1 
ATOM   1457 C  CA  . GLY A 1 291 ? 25.86737 4.91510   -38.22295  1.000 13.29730  ? 249 GLY A CA  1 
ATOM   1458 C  C   . GLY A 1 291 ? 26.12261 5.08574   -36.75282  1.000 17.19800  ? 249 GLY A C   1 
ATOM   1459 O  O   . GLY A 1 291 ? 26.52921 6.16131   -36.30267  1.000 17.74427  ? 249 GLY A O   1 
ATOM   1460 N  N   . GLN A 1 292 ? 25.81709 4.02534   -36.00248  1.000 12.87302  ? 250 GLN A N   1 
ATOM   1461 C  CA  . GLN A 1 292 ? 26.10882 3.98427   -34.57277  1.000 17.16134  ? 250 GLN A CA  1 
ATOM   1462 C  C   . GLN A 1 292 ? 27.56358 4.34458   -34.32109  1.000 23.97322  ? 250 GLN A C   1 
ATOM   1463 O  O   . GLN A 1 292 ? 28.45657 3.78108   -34.95461  1.000 18.93917  ? 250 GLN A O   1 
ATOM   1464 C  CB  . GLN A 1 292 ? 25.86579 2.57151   -34.01519  1.000 18.15722  ? 250 GLN A CB  1 
ATOM   1465 C  CG  . GLN A 1 292 ? 26.07948 2.51400   -32.51027  1.000 14.44871  ? 250 GLN A CG  1 
ATOM   1466 C  CD  . GLN A 1 292 ? 24.88754 3.10240   -31.75612  1.000 22.97151  ? 250 GLN A CD  1 
ATOM   1467 O  OE1 . GLN A 1 292 ? 23.71814 2.70648   -32.00487  1.000 19.35953  ? 250 GLN A OE1 1 
ATOM   1468 N  NE2 . GLN A 1 292 ? 25.15782 4.04137   -30.83319  1.000 14.54204  ? 250 GLN A NE2 1 
ATOM   1469 N  N   . ALA A 1 293 ? 27.80021 5.23791   -33.35699  1.000 19.06372  ? 251 ALA A N   1 
ATOM   1470 C  CA  . ALA A 1 293 ? 29.15227 5.63540   -33.00540  1.000 17.42653  ? 251 ALA A CA  1 
ATOM   1471 C  C   . ALA A 1 293 ? 29.27364 5.56153   -31.49975  1.000 20.34405  ? 251 ALA A C   1 
ATOM   1472 O  O   . ALA A 1 293 ? 28.38395 5.03548   -30.84908  1.000 17.46209  ? 251 ALA A O   1 
ATOM   1473 C  CB  . ALA A 1 293 ? 29.49031 7.04913   -33.52240  1.000 20.32870  ? 251 ALA A CB  1 
ATOM   1474 N  N   . SER A 1 294 ? 30.35247 6.07969   -30.93270  1.000 17.04142  ? 252 SER A N   1 
ATOM   1475 C  CA  . SER A 1 294 ? 30.60331 6.00525   -29.49887  1.000 17.29604  ? 252 SER A CA  1 
ATOM   1476 C  C   . SER A 1 294 ? 30.62844 7.43039   -28.96608  1.000 20.12970  ? 252 SER A C   1 
ATOM   1477 O  O   . SER A 1 294 ? 31.21012 8.31641   -29.60806  1.000 19.80795  ? 252 SER A O   1 
ATOM   1478 C  CB  . SER A 1 294 ? 31.95372 5.28106   -29.25660  1.000 21.99635  ? 252 SER A CB  1 
ATOM   1479 O  OG  . SER A 1 294 ? 32.26566 5.11663   -27.88761  1.000 25.72222  ? 252 SER A OG  1 
ATOM   1480 N  N   . TYR A 1 295 ? 30.03611 7.65441   -27.78948  1.000 16.66111  ? 253 TYR A N   1 
ATOM   1481 C  CA  . TYR A 1 295 ? 29.88008 9.00177   -27.22155  1.000 21.29093  ? 253 TYR A CA  1 
ATOM   1482 C  C   . TYR A 1 295 ? 30.36589 8.95606   -25.78714  1.000 20.35953  ? 253 TYR A C   1 
ATOM   1483 O  O   . TYR A 1 295 ? 30.03999 8.01622   -25.05276  1.000 19.24467  ? 253 TYR A O   1 
ATOM   1484 C  CB  . TYR A 1 295 ? 28.41953 9.50704   -27.29116  1.000 16.28836  ? 253 TYR A CB  1 
ATOM   1485 C  CG  . TYR A 1 295 ? 27.72080 8.91578   -28.47395  1.000 17.09609  ? 253 TYR A CG  1 
ATOM   1486 C  CD1 . TYR A 1 295 ? 28.06470 9.30779   -29.75682  1.000 14.61312  ? 253 TYR A CD1 1 
ATOM   1487 C  CD2 . TYR A 1 295 ? 26.74389 7.92726   -28.31976  1.000 14.74916  ? 253 TYR A CD2 1 
ATOM   1488 C  CE1 . TYR A 1 295 ? 27.45986 8.72998   -30.86520  1.000 14.62526  ? 253 TYR A CE1 1 
ATOM   1489 C  CE2 . TYR A 1 295 ? 26.13102 7.34202   -29.43536  1.000 10.78879  ? 253 TYR A CE2 1 
ATOM   1490 C  CZ  . TYR A 1 295 ? 26.50352 7.73132   -30.69490  1.000 13.27318  ? 253 TYR A CZ  1 
ATOM   1491 O  OH  . TYR A 1 295 ? 25.91079 7.18996   -31.81237  1.000 14.34087  ? 253 TYR A OH  1 
ATOM   1492 N  N   . LYS A 1 296 ? 31.24755 9.88855   -25.42950  1.000 13.56934  ? 254 LYS A N   1 
ATOM   1493 C  CA  . LYS A 1 296 ? 31.77864 9.95890   -24.07497  1.000 19.01778  ? 254 LYS A CA  1 
ATOM   1494 C  C   . LYS A 1 296 ? 31.50837 11.32690  -23.46268  1.000 22.01152  ? 254 LYS A C   1 
ATOM   1495 O  O   . LYS A 1 296 ? 31.61661 12.34546  -24.14970  1.000 15.62435  ? 254 LYS A O   1 
ATOM   1496 C  CB  . LYS A 1 296 ? 33.29684 9.69529   -24.05982  1.000 19.30948  ? 254 LYS A CB  1 
ATOM   1497 C  CG  . LYS A 1 296 ? 33.62537 8.20519   -24.25913  1.000 27.99654  ? 254 LYS A CG  1 
ATOM   1498 C  CD  . LYS A 1 296 ? 35.10196 7.91166   -23.90517  1.000 23.86314  ? 254 LYS A CD  1 
ATOM   1499 C  CE  . LYS A 1 296 ? 35.39842 6.42908   -24.09351  1.000 30.78288  ? 254 LYS A CE  1 
ATOM   1500 N  NZ  . LYS A 1 296 ? 36.81999 6.25161   -23.75235  1.000 37.32685  ? 254 LYS A NZ  1 
ATOM   1501 N  N   . ILE A 1 297 ? 31.17573 11.34431  -22.16793  1.000 17.49277  ? 255 ILE A N   1 
ATOM   1502 C  CA  . ILE A 1 297 ? 31.12129 12.57935  -21.39161  1.000 19.43075  ? 255 ILE A CA  1 
ATOM   1503 C  C   . ILE A 1 297 ? 32.40833 12.69637  -20.58088  1.000 24.01916  ? 255 ILE A C   1 
ATOM   1504 O  O   . ILE A 1 297 ? 32.82578 11.73087  -19.92495  1.000 22.53181  ? 255 ILE A O   1 
ATOM   1505 C  CB  . ILE A 1 297 ? 29.90052 12.62118  -20.45502  1.000 24.78817  ? 255 ILE A CB  1 
ATOM   1506 C  CG1 . ILE A 1 297 ? 28.59938 12.29140  -21.19993  1.000 24.85168  ? 255 ILE A CG1 1 
ATOM   1507 C  CG2 . ILE A 1 297 ? 29.81279 13.99039  -19.79610  1.000 19.18256  ? 255 ILE A CG2 1 
ATOM   1508 C  CD1 . ILE A 1 297 ? 27.41469 12.02046  -20.24980  1.000 20.43375  ? 255 ILE A CD1 1 
ATOM   1509 N  N   . PHE A 1 298 ? 33.02125 13.89004  -20.59287  1.000 25.00827  ? 256 PHE A N   1 
ATOM   1510 C  CA  . PHE A 1 298 ? 34.24843 14.17385  -19.84607  1.000 20.72692  ? 256 PHE A CA  1 
ATOM   1511 C  C   . PHE A 1 298 ? 34.00868 15.24306  -18.78418  1.000 18.92071  ? 256 PHE A C   1 
ATOM   1512 O  O   . PHE A 1 298 ? 33.37180 16.26927  -19.05013  1.000 26.28514  ? 256 PHE A O   1 
ATOM   1513 C  CB  . PHE A 1 298 ? 35.37510 14.65211  -20.77664  1.000 15.03678  ? 256 PHE A CB  1 
ATOM   1514 C  CG  . PHE A 1 298 ? 35.84207 13.61032  -21.74578  1.000 17.53054  ? 256 PHE A CG  1 
ATOM   1515 C  CD1 . PHE A 1 298 ? 35.22900 13.46661  -22.98414  1.000 19.91808  ? 256 PHE A CD1 1 
ATOM   1516 C  CD2 . PHE A 1 298 ? 36.88299 12.76558  -21.42457  1.000 16.66944  ? 256 PHE A CD2 1 
ATOM   1517 C  CE1 . PHE A 1 298 ? 35.66798 12.49287  -23.87831  1.000 21.59706  ? 256 PHE A CE1 1 
ATOM   1518 C  CE2 . PHE A 1 298 ? 37.30527 11.81291  -22.30303  1.000 18.23420  ? 256 PHE A CE2 1 
ATOM   1519 C  CZ  . PHE A 1 298 ? 36.69299 11.68409  -23.53525  1.000 21.36848  ? 256 PHE A CZ  1 
ATOM   1520 N  N   . LYS A 1 299 ? 34.53462 15.00325  -17.58788  1.000 18.72802  ? 257 LYS A N   1 
ATOM   1521 C  CA  . LYS A 1 299 ? 34.57263 15.98730  -16.51232  1.000 17.47934  ? 257 LYS A CA  1 
ATOM   1522 C  C   . LYS A 1 299 ? 36.02183 16.45380  -16.36778  1.000 23.13226  ? 257 LYS A C   1 
ATOM   1523 O  O   . LYS A 1 299 ? 36.92002 15.62020  -16.22878  1.000 18.06555  ? 257 LYS A O   1 
ATOM   1524 C  CB  . LYS A 1 299 ? 34.08039 15.36144  -15.20904  1.000 14.33990  ? 257 LYS A CB  1 
ATOM   1525 C  CG  . LYS A 1 299 ? 33.94450 16.30229  -14.03353  1.000 20.21403  ? 257 LYS A CG  1 
ATOM   1526 C  CD  . LYS A 1 299 ? 33.56795 15.51484  -12.79048  1.000 26.85077  ? 257 LYS A CD  1 
ATOM   1527 C  CE  . LYS A 1 299 ? 33.32938 16.42609  -11.59623  1.000 26.33789  ? 257 LYS A CE  1 
ATOM   1528 N  NZ  . LYS A 1 299 ? 32.98954 15.57024  -10.42934  1.000 29.38895  ? 257 LYS A NZ  1 
ATOM   1529 N  N   . ILE A 1 300 ? 36.25297 17.76788  -16.40801  1.000 18.79355  ? 258 ILE A N   1 
ATOM   1530 C  CA  . ILE A 1 300 ? 37.60626 18.32857  -16.45629  1.000 19.41017  ? 258 ILE A CA  1 
ATOM   1531 C  C   . ILE A 1 300 ? 37.75910 19.41685  -15.39876  1.000 19.73913  ? 258 ILE A C   1 
ATOM   1532 O  O   . ILE A 1 300 ? 36.94320 20.34555  -15.33777  1.000 21.27077  ? 258 ILE A O   1 
ATOM   1533 C  CB  . ILE A 1 300 ? 37.92227 18.89409  -17.84816  1.000 16.36906  ? 258 ILE A CB  1 
ATOM   1534 C  CG1 . ILE A 1 300 ? 37.80401 17.78301  -18.88855  1.000 16.87552  ? 258 ILE A CG1 1 
ATOM   1535 C  CG2 . ILE A 1 300 ? 39.33292 19.53822  -17.84923  1.000 19.26198  ? 258 ILE A CG2 1 
ATOM   1536 C  CD1 . ILE A 1 300 ? 37.88464 18.22320  -20.32814  1.000 20.81449  ? 258 ILE A CD1 1 
ATOM   1537 N  N   . GLU A 1 301 ? 38.80437 19.30650  -14.56993  1.000 18.73469  ? 259 GLU A N   1 
ATOM   1538 C  CA  . GLU A 1 301 ? 39.08247 20.27861  -13.51710  1.000 21.23267  ? 259 GLU A CA  1 
ATOM   1539 C  C   . GLU A 1 301 ? 40.50713 20.78752  -13.65995  1.000 25.92483  ? 259 GLU A C   1 
ATOM   1540 O  O   . GLU A 1 301 ? 41.46052 19.99030  -13.69123  1.000 20.61131  ? 259 GLU A O   1 
ATOM   1541 C  CB  . GLU A 1 301 ? 38.85925 19.67817  -12.13818  1.000 19.83116  ? 259 GLU A CB  1 
ATOM   1542 C  CG  . GLU A 1 301 ? 37.39611 19.40422  -11.90245  1.000 30.15098  ? 259 GLU A CG  1 
ATOM   1543 C  CD  . GLU A 1 301 ? 37.15320 18.55094  -10.69350  1.000 32.90943  ? 259 GLU A CD  1 
ATOM   1544 O  OE1 . GLU A 1 301 ? 38.14856 18.20419  -10.01752  1.000 39.79271  ? 259 GLU A OE1 1 
ATOM   1545 O  OE2 . GLU A 1 301 ? 35.97177 18.20471  -10.43702  1.000 42.51755  ? 259 GLU A OE2 1 
ATOM   1546 N  N   . LYS A 1 302 ? 40.64406 22.11260  -13.76363  1.000 23.28386  ? 260 LYS A N   1 
ATOM   1547 C  CA  . LYS A 1 302 ? 41.94345 22.76093  -14.00768  1.000 27.70284  ? 260 LYS A CA  1 
ATOM   1548 C  C   . LYS A 1 302 ? 42.62259 22.16150  -15.23700  1.000 22.13837  ? 260 LYS A C   1 
ATOM   1549 O  O   . LYS A 1 302 ? 43.83336 21.98104  -15.26915  1.000 23.61097  ? 260 LYS A O   1 
ATOM   1550 C  CB  . LYS A 1 302 ? 42.86636 22.63773  -12.79169  1.000 22.12512  ? 260 LYS A CB  1 
ATOM   1551 C  CG  . LYS A 1 302 ? 42.30126 23.18408  -11.50352  1.000 29.85292  ? 260 LYS A CG  1 
ATOM   1552 C  CD  . LYS A 1 302 ? 42.31026 24.68184  -11.49340  1.000 31.67457  ? 260 LYS A CD  1 
ATOM   1553 C  CE  . LYS A 1 302 ? 42.03162 25.25408  -10.08985  1.000 43.88741  ? 260 LYS A CE  1 
ATOM   1554 N  NZ  . LYS A 1 302 ? 41.77851 26.75245  -10.07404  1.000 30.13605  ? 260 LYS A NZ  1 
ATOM   1555 N  N   . GLY A 1 303 ? 41.82431 21.80718  -16.24386  1.000 21.68101  ? 261 GLY A N   1 
ATOM   1556 C  CA  . GLY A 1 303 ? 42.33785 21.21154  -17.45511  1.000 17.48477  ? 261 GLY A CA  1 
ATOM   1557 C  C   . GLY A 1 303 ? 42.69852 19.73743  -17.38582  1.000 18.86237  ? 261 GLY A C   1 
ATOM   1558 O  O   . GLY A 1 303 ? 43.14774 19.19822  -18.40747  1.000 20.80723  ? 261 GLY A O   1 
ATOM   1559 N  N   . LYS A 1 304 ? 42.53181 19.07169  -16.23402  1.000 19.05214  ? 262 LYS A N   1 
ATOM   1560 C  CA  . LYS A 1 304 ? 42.77713 17.63163  -16.08801  1.000 20.03816  ? 262 LYS A CA  1 
ATOM   1561 C  C   . LYS A 1 304 ? 41.47918 16.82488  -16.20859  1.000 23.17973  ? 262 LYS A C   1 
ATOM   1562 O  O   . LYS A 1 304 ? 40.48197 17.11510  -15.52245  1.000 26.05413  ? 262 LYS A O   1 
ATOM   1563 C  CB  . LYS A 1 304 ? 43.41757 17.31672  -14.73175  1.000 27.72800  ? 262 LYS A CB  1 
ATOM   1564 C  CG  . LYS A 1 304 ? 44.84525 17.81540  -14.51756  1.000 41.38687  ? 262 LYS A CG  1 
ATOM   1565 C  CD  . LYS A 1 304 ? 45.80881 17.27018  -15.56235  1.000 53.75793  ? 262 LYS A CD  1 
ATOM   1566 C  CE  . LYS A 1 304 ? 46.17815 15.76607  -15.31554  1.000 52.61942  ? 262 LYS A CE  1 
ATOM   1567 N  NZ  . LYS A 1 304 ? 47.45197 15.31751  -16.04562  1.000 44.08423  ? 262 LYS A NZ  1 
ATOM   1568 N  N   . VAL A 1 305 ? 41.48483 15.81174  -17.06706  1.000 26.29998  ? 263 VAL A N   1 
ATOM   1569 C  CA  . VAL A 1 305 ? 40.34351 14.89826  -17.09784  1.000 23.21989  ? 263 VAL A CA  1 
ATOM   1570 C  C   . VAL A 1 305 ? 40.32521 14.14851  -15.76913  1.000 25.55783  ? 263 VAL A C   1 
ATOM   1571 O  O   . VAL A 1 305 ? 41.25658 13.40421  -15.45183  1.000 26.85705  ? 263 VAL A O   1 
ATOM   1572 C  CB  . VAL A 1 305 ? 40.41111 13.92769  -18.28400  1.000 22.83392  ? 263 VAL A CB  1 
ATOM   1573 C  CG1 . VAL A 1 305 ? 39.23702 12.98683  -18.24102  1.000 20.77409  ? 263 VAL A CG1 1 
ATOM   1574 C  CG2 . VAL A 1 305 ? 40.43520 14.66935  -19.59652  1.000 19.71527  ? 263 VAL A CG2 1 
ATOM   1575 N  N   . VAL A 1 306 ? 39.29100 14.37453  -14.96952  1.000 19.04463  ? 264 VAL A N   1 
ATOM   1576 C  CA  . VAL A 1 306 ? 39.16362 13.68304  -13.69861  1.000 22.50253  ? 264 VAL A CA  1 
ATOM   1577 C  C   . VAL A 1 306 ? 38.16502 12.53234  -13.75799  1.000 27.76406  ? 264 VAL A C   1 
ATOM   1578 O  O   . VAL A 1 306 ? 38.20587 11.65582  -12.88317  1.000 24.53867  ? 264 VAL A O   1 
ATOM   1579 C  CB  . VAL A 1 306 ? 38.78421 14.65291  -12.56050  1.000 22.77413  ? 264 VAL A CB  1 
ATOM   1580 C  CG1 . VAL A 1 306 ? 39.92472 15.63934  -12.28684  1.000 23.97473  ? 264 VAL A CG1 1 
ATOM   1581 C  CG2 . VAL A 1 306 ? 37.48126 15.40948  -12.87911  1.000 22.66202  ? 264 VAL A CG2 1 
ATOM   1582 N  N   . LYS A 1 307 ? 37.28299 12.49856  -14.75751  1.000 21.33998  ? 265 LYS A N   1 
ATOM   1583 C  CA  . LYS A 1 307 ? 36.33088 11.39984  -14.87901  1.000 23.35666  ? 265 LYS A CA  1 
ATOM   1584 C  C   . LYS A 1 307 ? 35.81427 11.40141  -16.30842  1.000 23.58124  ? 265 LYS A C   1 
ATOM   1585 O  O   . LYS A 1 307 ? 35.69099 12.45611  -16.92322  1.000 24.75971  ? 265 LYS A O   1 
ATOM   1586 C  CB  . LYS A 1 307 ? 35.18572 11.55541  -13.86074  1.000 21.84383  ? 265 LYS A CB  1 
ATOM   1587 C  CG  . LYS A 1 307 ? 34.32424 10.28751  -13.58155  1.000 29.46690  ? 265 LYS A CG  1 
ATOM   1588 C  CD  . LYS A 1 307 ? 33.21197 10.63232  -12.55139  1.000 31.49805  ? 265 LYS A CD  1 
ATOM   1589 C  CE  . LYS A 1 307 ? 32.61084 9.40541   -11.85496  1.000 42.75703  ? 265 LYS A CE  1 
ATOM   1590 N  NZ  . LYS A 1 307 ? 31.97226 8.49501   -12.81901  1.000 38.11863  ? 265 LYS A NZ  1 
ATOM   1591 N  N   . SER A 1 308 ? 35.55032 10.21941  -16.85612  1.000 24.03190  ? 266 SER A N   1 
ATOM   1592 C  CA  . SER A 1 308 ? 34.82801 10.16037  -18.12166  1.000 25.70781  ? 266 SER A CA  1 
ATOM   1593 C  C   . SER A 1 308 ? 33.88471 8.96326   -18.07840  1.000 25.71648  ? 266 SER A C   1 
ATOM   1594 O  O   . SER A 1 308 ? 34.09309 8.01934   -17.32556  1.000 24.16125  ? 266 SER A O   1 
ATOM   1595 C  CB  . SER A 1 308 ? 35.75574 10.07313  -19.34197  1.000 24.52295  ? 266 SER A CB  1 
ATOM   1596 O  OG  . SER A 1 308 ? 36.50189 8.86891   -19.35103  1.000 26.99231  ? 266 SER A OG  1 
ATOM   1597 N  N   . VAL A 1 309 ? 32.83596 9.00692   -18.88894  1.000 20.16926  ? 267 VAL A N   1 
ATOM   1598 C  CA  . VAL A 1 309 ? 31.87242 7.91515   -18.95907  1.000 28.40352  ? 267 VAL A CA  1 
ATOM   1599 C  C   . VAL A 1 309 ? 31.50111 7.70684   -20.41869  1.000 30.58379  ? 267 VAL A C   1 
ATOM   1600 O  O   . VAL A 1 309 ? 31.28468 8.67618   -21.14864  1.000 29.59971  ? 267 VAL A O   1 
ATOM   1601 C  CB  . VAL A 1 309 ? 30.62190 8.19935   -18.10223  1.000 37.18295  ? 267 VAL A CB  1 
ATOM   1602 C  CG1 . VAL A 1 309 ? 29.53010 7.19070   -18.41319  1.000 44.25744  ? 267 VAL A CG1 1 
ATOM   1603 C  CG2 . VAL A 1 309 ? 30.98813 8.09514   -16.63008  1.000 36.13382  ? 267 VAL A CG2 1 
ATOM   1604 N  N   . GLU A 1 310 ? 31.46832 6.45384   -20.87015  1.000 25.72384  ? 268 GLU A N   1 
ATOM   1605 C  CA  . GLU A 1 310 ? 30.91804 6.19125   -22.19414  1.000 26.78577  ? 268 GLU A CA  1 
ATOM   1606 C  C   . GLU A 1 310 ? 29.40003 6.04575   -22.08589  1.000 22.31121  ? 268 GLU A C   1 
ATOM   1607 O  O   . GLU A 1 310 ? 28.90033 5.24747   -21.28961  1.000 30.20069  ? 268 GLU A O   1 
ATOM   1608 C  CB  . GLU A 1 310 ? 31.54217 4.95585   -22.85751  1.000 26.72731  ? 268 GLU A CB  1 
ATOM   1609 C  CG  . GLU A 1 310 ? 30.75052 4.54526   -24.10665  1.000 35.70043  ? 268 GLU A CG  1 
ATOM   1610 C  CD  . GLU A 1 310 ? 31.53606 3.74543   -25.15345  1.000 46.92471  ? 268 GLU A CD  1 
ATOM   1611 O  OE1 . GLU A 1 310 ? 30.96411 3.51117   -26.25564  1.000 36.32303  ? 268 GLU A OE1 1 
ATOM   1612 O  OE2 . GLU A 1 310 ? 32.71213 3.39214   -24.90649  1.000 38.10586  ? 268 GLU A OE2 1 
ATOM   1613 N  N   . MET A 1 311 ? 28.67353 6.82035   -22.88881  1.000 21.66285  ? 269 MET A N   1 
ATOM   1614 C  CA  . MET A 1 311 ? 27.21588 6.75611   -22.88080  1.000 26.63879  ? 269 MET A CA  1 
ATOM   1615 C  C   . MET A 1 311 ? 26.73719 5.45988   -23.52152  1.000 27.13314  ? 269 MET A C   1 
ATOM   1616 O  O   . MET A 1 311 ? 27.26940 5.02419   -24.54840  1.000 23.97136  ? 269 MET A O   1 
ATOM   1617 C  CB  . MET A 1 311 ? 26.62589 7.94637   -23.62289  1.000 24.01044  ? 269 MET A CB  1 
ATOM   1618 C  CG  . MET A 1 311 ? 26.80059 9.30600   -22.92776  1.000 25.21971  ? 269 MET A CG  1 
ATOM   1619 S  SD  . MET A 1 311 ? 26.76437 10.70506  -24.09529  1.000 22.66649  ? 269 MET A SD  1 
ATOM   1620 C  CE  . MET A 1 311 ? 25.07487 10.40992  -24.75685  1.000 20.74739  ? 269 MET A CE  1 
ATOM   1621 N  N   . ASN A 1 312 ? 25.76030 4.80597   -22.88370  1.000 27.95181  ? 270 ASN A N   1 
ATOM   1622 C  CA  . ASN A 1 312 ? 25.13077 3.62277   -23.47667  1.000 20.80216  ? 270 ASN A CA  1 
ATOM   1623 C  C   . ASN A 1 312 ? 23.89878 4.11377   -24.21108  1.000 26.37813  ? 270 ASN A C   1 
ATOM   1624 O  O   . ASN A 1 312 ? 22.82420 4.29262   -23.63632  1.000 22.93899  ? 270 ASN A O   1 
ATOM   1625 C  CB  . ASN A 1 312 ? 24.81088 2.58819   -22.40369  1.000 24.93356  ? 270 ASN A CB  1 
ATOM   1626 C  CG  . ASN A 1 312 ? 24.10608 1.34751   -22.95557  1.000 36.23135  ? 270 ASN A CG  1 
ATOM   1627 O  OD1 . ASN A 1 312 ? 24.33535 0.92137   -24.09656  1.000 39.81121  ? 270 ASN A OD1 1 
ATOM   1628 N  ND2 . ASN A 1 312 ? 23.27828 0.73190   -22.11711  1.000 37.18937  ? 270 ASN A ND2 1 
ATOM   1629 N  N   . ALA A 1 313 ? 24.04404 4.36261   -25.49755  1.000 20.22859  ? 271 ALA A N   1 
ATOM   1630 C  CA  . ALA A 1 313 ? 22.99765 5.04117   -26.25763  1.000 13.45589  ? 271 ALA A CA  1 
ATOM   1631 C  C   . ALA A 1 313 ? 22.70430 4.29972   -27.55345  1.000 21.99215  ? 271 ALA A C   1 
ATOM   1632 O  O   . ALA A 1 313 ? 22.83721 4.85787   -28.64869  1.000 20.23868  ? 271 ALA A O   1 
ATOM   1633 C  CB  . ALA A 1 313 ? 23.38722 6.50422   -26.51980  1.000 14.39181  ? 271 ALA A CB  1 
ATOM   1634 N  N   . PRO A 1 314 ? 22.25808 3.03430   -27.46789  1.000 19.00364  ? 272 PRO A N   1 
ATOM   1635 C  CA  . PRO A 1 314 ? 21.98342 2.29091   -28.69529  1.000 13.95520  ? 272 PRO A CA  1 
ATOM   1636 C  C   . PRO A 1 314 ? 20.87643 2.97634   -29.47808  1.000 15.32338  ? 272 PRO A C   1 
ATOM   1637 O  O   . PRO A 1 314 ? 19.86117 3.38318   -28.91731  1.000 23.85599  ? 272 PRO A O   1 
ATOM   1638 C  CB  . PRO A 1 314 ? 21.53945 0.90074   -28.19593  1.000 21.79707  ? 272 PRO A CB  1 
ATOM   1639 C  CG  . PRO A 1 314 ? 21.01219 1.12374   -26.82648  1.000 24.60544  ? 272 PRO A CG  1 
ATOM   1640 C  CD  . PRO A 1 314 ? 21.85358 2.29606   -26.26372  1.000 18.04734  ? 272 PRO A CD  1 
ATOM   1641 N  N   . ASN A 1 315 ? 21.08186 3.07662   -30.78677  1.000 11.19709  ? 273 ASN A N   1 
ATOM   1642 C  CA  . ASN A 1 315 ? 20.20702 3.65972   -31.78659  1.000 17.12278  ? 273 ASN A CA  1 
ATOM   1643 C  C   . ASN A 1 315 ? 20.16710 5.19202   -31.72065  1.000 15.45379  ? 273 ASN A C   1 
ATOM   1644 O  O   . ASN A 1 315 ? 19.47169 5.81210   -32.54488  1.000 17.34634  ? 273 ASN A O   1 
ATOM   1645 C  CB  . ASN A 1 315 ? 18.77187 3.10995   -31.70657  1.000 16.65637  ? 273 ASN A CB  1 
ATOM   1646 C  CG  . ASN A 1 315 ? 18.13791 3.01648   -33.06343  1.000 22.08602  ? 273 ASN A CG  1 
ATOM   1647 O  OD1 . ASN A 1 315 ? 18.76416 2.48584   -33.99169  1.000 21.50382  ? 273 ASN A OD1 1 
ATOM   1648 N  ND2 . ASN A 1 315 ? 16.91504 3.55576   -33.21452  1.000 26.88616  ? 273 ASN A ND2 1 
ATOM   1649 N  N   . TYR A 1 316 ? 20.91469 5.81689   -30.80887  1.000 22.91431  ? 274 TYR A N   1 
ATOM   1650 C  CA  . TYR A 1 316 ? 21.11885 7.26557   -30.76246  1.000 14.52630  ? 274 TYR A CA  1 
ATOM   1651 C  C   . TYR A 1 316 ? 22.39128 7.66141   -31.49768  1.000 23.79786  ? 274 TYR A C   1 
ATOM   1652 O  O   . TYR A 1 316 ? 23.34209 6.87558   -31.58074  1.000 18.29488  ? 274 TYR A O   1 
ATOM   1653 C  CB  . TYR A 1 316 ? 21.25812 7.72821   -29.31619  1.000 18.68159  ? 274 TYR A CB  1 
ATOM   1654 C  CG  . TYR A 1 316 ? 20.01595 7.68597   -28.48030  1.000 26.81645  ? 274 TYR A CG  1 
ATOM   1655 C  CD1 . TYR A 1 316 ? 19.23677 6.54649   -28.41061  1.000 31.89094  ? 274 TYR A CD1 1 
ATOM   1656 C  CD2 . TYR A 1 316 ? 19.63514 8.79080   -27.73664  1.000 28.77514  ? 274 TYR A CD2 1 
ATOM   1657 C  CE1 . TYR A 1 316 ? 18.09390 6.52735   -27.64507  1.000 42.18813  ? 274 TYR A CE1 1 
ATOM   1658 C  CE2 . TYR A 1 316 ? 18.51389 8.76862   -26.96957  1.000 29.90132  ? 274 TYR A CE2 1 
ATOM   1659 C  CZ  . TYR A 1 316 ? 17.74306 7.64124   -26.92514  1.000 33.17893  ? 274 TYR A CZ  1 
ATOM   1660 O  OH  . TYR A 1 316 ? 16.62144 7.62556   -26.14575  1.000 34.77014  ? 274 TYR A OH  1 
ATOM   1661 N  N   . HIS A 1 317 ? 22.43931 8.91742   -31.97194  1.000 18.94913  ? 275 HIS A N   1 
ATOM   1662 C  CA  . HIS A 1 317 ? 23.64530 9.46067   -32.58905  1.000 16.14055  ? 275 HIS A CA  1 
ATOM   1663 C  C   . HIS A 1 317 ? 23.86435 10.89913  -32.11547  1.000 22.27286  ? 275 HIS A C   1 
ATOM   1664 O  O   . HIS A 1 317 ? 22.95673 11.73329  -32.22305  1.000 16.83092  ? 275 HIS A O   1 
ATOM   1665 C  CB  . HIS A 1 317 ? 23.56673 9.40661   -34.10960  1.000 15.69831  ? 275 HIS A CB  1 
ATOM   1666 C  CG  . HIS A 1 317 ? 24.89388 9.58871   -34.78347  1.000 23.08658  ? 275 HIS A CG  1 
ATOM   1667 N  ND1 . HIS A 1 317 ? 25.26908 10.77191  -35.39627  1.000 19.92004  ? 275 HIS A ND1 1 
ATOM   1668 C  CD2 . HIS A 1 317 ? 25.94584 8.74396   -34.91589  1.000 21.93438  ? 275 HIS A CD2 1 
ATOM   1669 C  CE1 . HIS A 1 317 ? 26.48535 10.63931  -35.89303  1.000 21.62754  ? 275 HIS A CE1 1 
ATOM   1670 N  NE2 . HIS A 1 317 ? 26.92102 9.42241   -35.60911  1.000 19.23997  ? 275 HIS A NE2 1 
ATOM   1671 N  N   . TYR A 1 318 ? 25.05911 11.16507  -31.56884  1.000 18.05460  ? 276 TYR A N   1 
ATOM   1672 C  CA  . TYR A 1 318 ? 25.43115 12.43246  -30.94566  1.000 16.23601  ? 276 TYR A CA  1 
ATOM   1673 C  C   . TYR A 1 318 ? 26.62532 13.05148  -31.65443  1.000 22.99224  ? 276 TYR A C   1 
ATOM   1674 O  O   . TYR A 1 318 ? 27.69436 12.43522  -31.74257  1.000 17.88266  ? 276 TYR A O   1 
ATOM   1675 C  CB  . TYR A 1 318 ? 25.78869 12.27801  -29.46165  1.000 21.92366  ? 276 TYR A CB  1 
ATOM   1676 C  CG  . TYR A 1 318 ? 24.59928 12.02900  -28.54879  1.000 21.02684  ? 276 TYR A CG  1 
ATOM   1677 C  CD1 . TYR A 1 318 ? 24.11647 10.74056  -28.35830  1.000 26.52964  ? 276 TYR A CD1 1 
ATOM   1678 C  CD2 . TYR A 1 318 ? 23.95740 13.07441  -27.88438  1.000 23.35612  ? 276 TYR A CD2 1 
ATOM   1679 C  CE1 . TYR A 1 318 ? 23.03048 10.48954  -27.53356  1.000 24.82563  ? 276 TYR A CE1 1 
ATOM   1680 C  CE2 . TYR A 1 318 ? 22.84854 12.83119  -27.05495  1.000 22.16188  ? 276 TYR A CE2 1 
ATOM   1681 C  CZ  . TYR A 1 318 ? 22.39877 11.52970  -26.88892  1.000 24.93862  ? 276 TYR A CZ  1 
ATOM   1682 O  OH  . TYR A 1 318 ? 21.31176 11.23000  -26.08409  1.000 20.34640  ? 276 TYR A OH  1 
ATOM   1683 N  N   . GLU A 1 319 ? 26.45252 14.29489  -32.09544  1.000 21.76241  ? 277 GLU A N   1 
ATOM   1684 C  CA  . GLU A 1 319 ? 27.51668 15.07842  -32.68543  1.000 17.89760  ? 277 GLU A CA  1 
ATOM   1685 C  C   . GLU A 1 319 ? 27.32043 16.52684  -32.32568  1.000 21.76252  ? 277 GLU A C   1 
ATOM   1686 O  O   . GLU A 1 319 ? 26.18134 17.00269  -32.24972  1.000 17.99963  ? 277 GLU A O   1 
ATOM   1687 C  CB  . GLU A 1 319 ? 27.53359 14.96107  -34.20113  1.000 20.86675  ? 277 GLU A CB  1 
ATOM   1688 C  CG  . GLU A 1 319 ? 28.51999 13.90586  -34.67085  1.000 31.12957  ? 277 GLU A CG  1 
ATOM   1689 C  CD  . GLU A 1 319 ? 28.48408 13.77149  -36.15242  1.000 35.54152  ? 277 GLU A CD  1 
ATOM   1690 O  OE1 . GLU A 1 319 ? 27.85916 14.66718  -36.81613  1.000 33.58468  ? 277 GLU A OE1 1 
ATOM   1691 O  OE2 . GLU A 1 319 ? 29.02829 12.75502  -36.63796  1.000 24.10177  ? 277 GLU A OE2 1 
ATOM   1692 N  N   . GLU A 1 320 ? 28.44484 17.23368  -32.14693  1.000 16.00906  ? 278 GLU A N   1 
ATOM   1693 C  CA  . GLU A 1 320 ? 28.43898 18.69595  -32.08898  1.000 18.32813  ? 278 GLU A CA  1 
ATOM   1694 C  C   . GLU A 1 320 ? 27.42350 19.19771  -31.06200  1.000 15.48625  ? 278 GLU A C   1 
ATOM   1695 O  O   . GLU A 1 320 ? 26.47105 19.92163  -31.36642  1.000 19.67351  ? 278 GLU A O   1 
ATOM   1696 C  CB  . GLU A 1 320 ? 28.16525 19.26846  -33.47830  1.000 15.37074  ? 278 GLU A CB  1 
ATOM   1697 C  CG  . GLU A 1 320 ? 29.28465 19.04949  -34.47925  1.000 15.34227  ? 278 GLU A CG  1 
ATOM   1698 C  CD  . GLU A 1 320 ? 28.87699 19.47555  -35.88320  1.000 17.76856  ? 278 GLU A CD  1 
ATOM   1699 O  OE1 . GLU A 1 320 ? 27.67089 19.69513  -36.10713  1.000 22.71438  ? 278 GLU A OE1 1 
ATOM   1700 O  OE2 . GLU A 1 320 ? 29.74195 19.56154  -36.78709  1.000 22.70852  ? 278 GLU A OE2 1 
ATOM   1701 N  N   . CYS A 1 321 ? 27.62995 18.75983  -29.83322  1.000 12.99430  ? 279 CYS A N   1 
ATOM   1702 C  CA  . CYS A 1 321 ? 26.70055 19.04418  -28.75527  1.000 18.82809  ? 279 CYS A CA  1 
ATOM   1703 C  C   . CYS A 1 321 ? 26.76864 20.49513  -28.29187  1.000 22.27486  ? 279 CYS A C   1 
ATOM   1704 O  O   . CYS A 1 321 ? 27.85080 21.04468  -28.05204  1.000 20.33393  ? 279 CYS A O   1 
ATOM   1705 C  CB  . CYS A 1 321 ? 26.99750 18.10906  -27.57800  1.000 20.16670  ? 279 CYS A CB  1 
ATOM   1706 S  SG  . CYS A 1 321 ? 26.38921 16.41602  -27.82025  1.000 25.18168  ? 279 CYS A SG  1 
ATOM   1707 N  N   . SER A 1 322 ? 25.60014 21.10107  -28.10219  1.000 14.52904  ? 280 SER A N   1 
ATOM   1708 C  CA  . SER A 1 322 ? 25.47983 22.39527  -27.42724  1.000 19.80730  ? 280 SER A CA  1 
ATOM   1709 C  C   . SER A 1 322 ? 25.08804 22.12733  -25.98439  1.000 21.70934  ? 280 SER A C   1 
ATOM   1710 O  O   . SER A 1 322 ? 23.97281 21.66275  -25.71901  1.000 19.53400  ? 280 SER A O   1 
ATOM   1711 C  CB  . SER A 1 322 ? 24.43602 23.30246  -28.08816  1.000 21.38623  ? 280 SER A CB  1 
ATOM   1712 O  OG  . SER A 1 322 ? 24.78290 23.64553  -29.42042  1.000 17.57035  ? 280 SER A OG  1 
ATOM   1713 N  N   . CYS A 1 323 ? 26.00006 22.41966  -25.05513  1.000 20.28548  ? 281 CYS A N   1 
ATOM   1714 C  CA  . CYS A 1 323 ? 25.82958 22.09098  -23.64774  1.000 17.62698  ? 281 CYS A CA  1 
ATOM   1715 C  C   . CYS A 1 323 ? 25.79784 23.35871  -22.81484  1.000 27.92013  ? 281 CYS A C   1 
ATOM   1716 O  O   . CYS A 1 323 ? 26.65581 24.24281  -22.97030  1.000 23.84333  ? 281 CYS A O   1 
ATOM   1717 C  CB  . CYS A 1 323 ? 26.95268 21.20823  -23.13721  1.000 17.89073  ? 281 CYS A CB  1 
ATOM   1718 S  SG  . CYS A 1 323 ? 27.16114 19.65853  -24.06986  1.000 23.08483  ? 281 CYS A SG  1 
ATOM   1719 N  N   . TYR A 1 324 ? 24.86463 23.39907  -21.87749  1.000 11.98875  ? 282 TYR A N   1 
ATOM   1720 C  CA  . TYR A 1 324 ? 24.75990 24.51448  -20.95804  1.000 18.30493  ? 282 TYR A CA  1 
ATOM   1721 C  C   . TYR A 1 324 ? 24.51102 23.97376  -19.55912  1.000 19.53708  ? 282 TYR A C   1 
ATOM   1722 O  O   . TYR A 1 324 ? 24.02631 22.84866  -19.39950  1.000 22.22124  ? 282 TYR A O   1 
ATOM   1723 C  CB  . TYR A 1 324 ? 23.64043 25.48146  -21.37043  1.000 19.34525  ? 282 TYR A CB  1 
ATOM   1724 C  CG  . TYR A 1 324 ? 22.23884 24.88180  -21.37462  1.000 14.44773  ? 282 TYR A CG  1 
ATOM   1725 C  CD1 . TYR A 1 324 ? 21.44995 24.91224  -20.23638  1.000 17.16098  ? 282 TYR A CD1 1 
ATOM   1726 C  CD2 . TYR A 1 324 ? 21.69075 24.34947  -22.53491  1.000 20.81797  ? 282 TYR A CD2 1 
ATOM   1727 C  CE1 . TYR A 1 324 ? 20.16002 24.36666  -20.23377  1.000 16.03873  ? 282 TYR A CE1 1 
ATOM   1728 C  CE2 . TYR A 1 324 ? 20.39040 23.81471  -22.54652  1.000 13.86389  ? 282 TYR A CE2 1 
ATOM   1729 C  CZ  . TYR A 1 324 ? 19.63851 23.84497  -21.39543  1.000 17.11696  ? 282 TYR A CZ  1 
ATOM   1730 O  OH  . TYR A 1 324 ? 18.35379 23.33358  -21.38645  1.000 20.15491  ? 282 TYR A OH  1 
ATOM   1731 N  N   . PRO A 1 325 ? 24.86138 24.74318  -18.52890  1.000 17.57983  ? 283 PRO A N   1 
ATOM   1732 C  CA  . PRO A 1 325 ? 24.50389 24.39458  -17.15585  1.000 19.22839  ? 283 PRO A CA  1 
ATOM   1733 C  C   . PRO A 1 325 ? 23.09580 24.86771  -16.82817  1.000 22.59668  ? 283 PRO A C   1 
ATOM   1734 O  O   . PRO A 1 325 ? 22.62660 25.88789  -17.32979  1.000 22.01093  ? 283 PRO A O   1 
ATOM   1735 C  CB  . PRO A 1 325 ? 25.52210 25.18316  -16.32360  1.000 19.18936  ? 283 PRO A CB  1 
ATOM   1736 C  CG  . PRO A 1 325 ? 25.73541 26.35801  -17.10002  1.000 18.01662  ? 283 PRO A CG  1 
ATOM   1737 C  CD  . PRO A 1 325 ? 25.72982 25.92511  -18.55828  1.000 18.97858  ? 283 PRO A CD  1 
ATOM   1738 N  N   . ASP A 1 326 ? 22.41314 24.10143  -15.98087  1.000 22.09883  ? 284 ASP A N   1 
ATOM   1739 C  CA  . ASP A 1 326 ? 21.05826 24.47321  -15.57028  1.000 28.71284  ? 284 ASP A CA  1 
ATOM   1740 C  C   . ASP A 1 326 ? 20.83031 23.81070  -14.22281  1.000 30.47634  ? 284 ASP A C   1 
ATOM   1741 O  O   . ASP A 1 326 ? 20.73708 22.57893  -14.14712  1.000 25.32340  ? 284 ASP A O   1 
ATOM   1742 C  CB  . ASP A 1 326 ? 20.02390 24.02656  -16.60297  1.000 29.77529  ? 284 ASP A CB  1 
ATOM   1743 C  CG  . ASP A 1 326 ? 18.60350 24.67155  -16.39423  1.000 44.30650  ? 284 ASP A CG  1 
ATOM   1744 O  OD1 . ASP A 1 326 ? 18.37200 25.37624  -15.37230  1.000 31.50592  ? 284 ASP A OD1 1 
ATOM   1745 O  OD2 . ASP A 1 326 ? 17.70792 24.45256  -17.27220  1.000 43.42829  ? 284 ASP A OD2 1 
ATOM   1746 N  N   . ALA A 1 327 ? 20.81091 24.62178  -13.16772  1.000 26.63575  ? 285 ALA A N   1 
ATOM   1747 C  CA  . ALA A 1 327 ? 20.48240 24.15232  -11.82969  1.000 28.60327  ? 285 ALA A CA  1 
ATOM   1748 C  C   . ALA A 1 327 ? 21.49990 23.12883  -11.34276  1.000 29.72665  ? 285 ALA A C   1 
ATOM   1749 O  O   . ALA A 1 327 ? 21.16173 22.18994  -10.62076  1.000 33.78397  ? 285 ALA A O   1 
ATOM   1750 C  CB  . ALA A 1 327 ? 19.05350 23.58071  -11.78828  1.000 27.13121  ? 285 ALA A CB  1 
ATOM   1751 N  N   . GLY A 1 328 ? 22.76751 23.33083  -11.70924  1.000 25.03475  ? 286 GLY A N   1 
ATOM   1752 C  CA  . GLY A 1 328 ? 23.83881 22.49295  -11.22990  1.000 27.71119  ? 286 GLY A CA  1 
ATOM   1753 C  C   . GLY A 1 328 ? 24.04629 21.19074  -11.97386  1.000 30.87783  ? 286 GLY A C   1 
ATOM   1754 O  O   . GLY A 1 328 ? 24.93679 20.42771  -11.60018  1.000 31.15801  ? 286 GLY A O   1 
ATOM   1755 N  N   . ASP A 1 329 ? 23.23894 20.89348  -12.97580  1.000 24.80143  ? 287 ASP A N   1 
ATOM   1756 C  CA  . ASP A 1 329 ? 23.42441 19.77409  -13.88419  1.000 24.94576  ? 287 ASP A CA  1 
ATOM   1757 C  C   . ASP A 1 329 ? 23.78064 20.36492  -15.23936  1.000 23.59191  ? 287 ASP A C   1 
ATOM   1758 O  O   . ASP A 1 329 ? 23.75631 21.58998  -15.42622  1.000 22.34396  ? 287 ASP A O   1 
ATOM   1759 C  CB  . ASP A 1 329 ? 22.13991 18.92625  -14.00606  1.000 26.67625  ? 287 ASP A CB  1 
ATOM   1760 C  CG  . ASP A 1 329 ? 21.83882 18.08951  -12.77401  1.000 32.59490  ? 287 ASP A CG  1 
ATOM   1761 O  OD1 . ASP A 1 329 ? 22.65212 18.04570  -11.82415  1.000 39.47315  ? 287 ASP A OD1 1 
ATOM   1762 O  OD2 . ASP A 1 329 ? 20.76590 17.44215  -12.76825  1.000 44.19156  ? 287 ASP A OD2 1 
ATOM   1763 N  N   . ILE A 1 330 ? 24.04859 19.49638  -16.20992  1.000 20.58695  ? 288 ILE A N   1 
ATOM   1764 C  CA  . ILE A 1 330 ? 24.39644 19.92033  -17.55834  1.000 16.45396  ? 288 ILE A CA  1 
ATOM   1765 C  C   . ILE A 1 330 ? 23.35295 19.34377  -18.50705  1.000 21.03550  ? 288 ILE A C   1 
ATOM   1766 O  O   . ILE A 1 330 ? 22.97592 18.17573  -18.36894  1.000 17.04158  ? 288 ILE A O   1 
ATOM   1767 C  CB  . ILE A 1 330 ? 25.79256 19.41443  -17.95904  1.000 22.10891  ? 288 ILE A CB  1 
ATOM   1768 C  CG1 . ILE A 1 330 ? 26.82885 19.70252  -16.86994  1.000 19.30724  ? 288 ILE A CG1 1 
ATOM   1769 C  CG2 . ILE A 1 330 ? 26.19900 20.04983  -19.28223  1.000 19.61409  ? 288 ILE A CG2 1 
ATOM   1770 C  CD1 . ILE A 1 330 ? 26.92062 21.10066  -16.47901  1.000 27.45624  ? 288 ILE A CD1 1 
ATOM   1771 N  N   . MET A 1 331 ? 22.90582 20.14051  -19.48164  1.000 11.92698  ? 289 MET A N   1 
ATOM   1772 C  CA  . MET A 1 331 ? 22.02011 19.67060  -20.54053  1.000 19.83204  ? 289 MET A CA  1 
ATOM   1773 C  C   . MET A 1 331 ? 22.71373 19.89571  -21.86932  1.000 15.75899  ? 289 MET A C   1 
ATOM   1774 O  O   . MET A 1 331 ? 23.20384 20.98733  -22.11745  1.000 16.85530  ? 289 MET A O   1 
ATOM   1775 C  CB  . MET A 1 331 ? 20.66826 20.40608  -20.53841  1.000 14.66982  ? 289 MET A CB  1 
ATOM   1776 C  CG  . MET A 1 331 ? 19.78945 20.11524  -21.75635  1.000 20.61761  ? 289 MET A CG  1 
ATOM   1777 S  SD  . MET A 1 331 ? 19.23299 18.38277  -21.81240  1.000 24.54392  ? 289 MET A SD  1 
ATOM   1778 C  CE  . MET A 1 331 ? 18.17208 18.36456  -20.37235  1.000 23.02057  ? 289 MET A CE  1 
ATOM   1779 N  N   . CYS A 1 332 ? 22.71143 18.88899  -22.73859  1.000 17.54174  ? 290 CYS A N   1 
ATOM   1780 C  CA  . CYS A 1 332 ? 23.30043 19.03724  -24.05333  1.000 18.19545  ? 290 CYS A CA  1 
ATOM   1781 C  C   . CYS A 1 332 ? 22.27476 18.66019  -25.09977  1.000 21.86117  ? 290 CYS A C   1 
ATOM   1782 O  O   . CYS A 1 332 ? 21.62861 17.60971  -25.00551  1.000 19.62970  ? 290 CYS A O   1 
ATOM   1783 C  CB  . CYS A 1 332 ? 24.52261 18.14370  -24.25202  1.000 19.85701  ? 290 CYS A CB  1 
ATOM   1784 S  SG  . CYS A 1 332 ? 25.85338 18.36000  -23.12206  1.000 25.65395  ? 290 CYS A SG  1 
ATOM   1785 N  N   . VAL A 1 333 ? 22.19276 19.46945  -26.14052  1.000 13.95605  ? 291 VAL A N   1 
ATOM   1786 C  CA  . VAL A 1 333 ? 21.28679 19.22024  -27.25964  1.000 19.22616  ? 291 VAL A CA  1 
ATOM   1787 C  C   . VAL A 1 333 ? 22.16701 19.13476  -28.48849  1.000 20.48159  ? 291 VAL A C   1 
ATOM   1788 O  O   . VAL A 1 333 ? 22.98468 20.03185  -28.73979  1.000 16.01450  ? 291 VAL A O   1 
ATOM   1789 C  CB  . VAL A 1 333 ? 20.20123 20.31979  -27.39855  1.000 13.10158  ? 291 VAL A CB  1 
ATOM   1790 C  CG1 . VAL A 1 333 ? 19.38525 20.16072  -28.69322  1.000 14.19568  ? 291 VAL A CG1 1 
ATOM   1791 C  CG2 . VAL A 1 333 ? 19.27092 20.28951  -26.20444  1.000 11.98210  ? 291 VAL A CG2 1 
ATOM   1792 N  N   . CYS A 1 334 ? 22.02742 18.04690  -29.23761  1.000 16.34011  ? 292 CYS A N   1 
ATOM   1793 C  CA  . CYS A 1 334 ? 23.09322 17.72305  -30.16949  1.000 19.23577  ? 292 CYS A CA  1 
ATOM   1794 C  C   . CYS A 1 334 ? 22.53087 17.47869  -31.56132  1.000 18.19081  ? 292 CYS A C   1 
ATOM   1795 O  O   . CYS A 1 334 ? 21.40519 17.88219  -31.88206  1.000 19.29667  ? 292 CYS A O   1 
ATOM   1796 C  CB  . CYS A 1 334 ? 23.88454 16.53045  -29.63982  1.000 12.30530  ? 292 CYS A CB  1 
ATOM   1797 S  SG  . CYS A 1 334 ? 24.28450 16.68546  -27.87742  1.000 21.19448  ? 292 CYS A SG  1 
ATOM   1798 N  N   . ARG A 1 335 ? 23.34941 16.90196  -32.41438  1.000 13.93529  ? 293 ARG A N   1 
ATOM   1799 C  CA  . ARG A 1 335 ? 23.03174 16.68043  -33.81060  1.000 14.73545  ? 293 ARG A CA  1 
ATOM   1800 C  C   . ARG A 1 335 ? 23.08959 15.17417  -34.04154  1.000 20.16900  ? 293 ARG A C   1 
ATOM   1801 O  O   . ARG A 1 335 ? 24.10297 14.54411  -33.71295  1.000 16.60434  ? 293 ARG A O   1 
ATOM   1802 C  CB  . ARG A 1 335 ? 24.07024 17.39417  -34.67128  1.000 12.39429  ? 293 ARG A CB  1 
ATOM   1803 C  CG  . ARG A 1 335 ? 23.96995 17.16740  -36.15377  1.000 13.76663  ? 293 ARG A CG  1 
ATOM   1804 C  CD  . ARG A 1 335 ? 25.19249 17.80372  -36.80247  1.000 18.19787  ? 293 ARG A CD  1 
ATOM   1805 N  NE  . ARG A 1 335 ? 25.41996 17.39515  -38.18354  1.000 13.33128  ? 293 ARG A NE  1 
ATOM   1806 C  CZ  . ARG A 1 335 ? 26.16619 18.05775  -39.05312  1.000 19.99090  ? 293 ARG A CZ  1 
ATOM   1807 N  NH1 . ARG A 1 335 ? 26.77017 19.20832  -38.72587  1.000 18.75747  ? 293 ARG A NH1 1 
ATOM   1808 N  NH2 . ARG A 1 335 ? 26.33478 17.54935  -40.26965  1.000 15.03757  ? 293 ARG A NH2 1 
ATOM   1809 N  N   . ASP A 1 336 ? 22.00817 14.59472  -34.57007  1.000 17.51026  ? 294 ASP A N   1 
ATOM   1810 C  CA  . ASP A 1 336 ? 21.98130 13.18415  -34.98697  1.000 13.75969  ? 294 ASP A CA  1 
ATOM   1811 C  C   . ASP A 1 336 ? 22.28491 13.20175  -36.47223  1.000 17.03346  ? 294 ASP A C   1 
ATOM   1812 O  O   . ASP A 1 336 ? 21.46547 13.65573  -37.26825  1.000 19.53685  ? 294 ASP A O   1 
ATOM   1813 C  CB  . ASP A 1 336 ? 20.61996 12.53513  -34.69357  1.000 15.20259  ? 294 ASP A CB  1 
ATOM   1814 C  CG  . ASP A 1 336 ? 20.47052 11.08760  -35.25493  1.000 17.91882  ? 294 ASP A CG  1 
ATOM   1815 O  OD1 . ASP A 1 336 ? 21.09027 10.71337  -36.27866  1.000 18.18546  ? 294 ASP A OD1 1 
ATOM   1816 O  OD2 . ASP A 1 336 ? 19.68988 10.30753  -34.66421  1.000 20.33402  ? 294 ASP A OD2 1 
ATOM   1817 N  N   . ASN A 1 337 ? 23.47535 12.76103  -36.84582  1.000 14.01014  ? 295 ASN A N   1 
ATOM   1818 C  CA  . ASN A 1 337 ? 23.83832 12.77706  -38.24848  1.000 13.63408  ? 295 ASN A CA  1 
ATOM   1819 C  C   . ASN A 1 337 ? 23.48661 11.46390  -38.93900  1.000 22.14910  ? 295 ASN A C   1 
ATOM   1820 O  O   . ASN A 1 337 ? 23.58809 11.35996  -40.17074  1.000 19.33096  ? 295 ASN A O   1 
ATOM   1821 C  CB  . ASN A 1 337 ? 25.33277 13.05497  -38.36834  1.000 14.88563  ? 295 ASN A CB  1 
ATOM   1822 C  CG  . ASN A 1 337 ? 25.63488 13.86442  -39.54908  1.000 20.41437  ? 295 ASN A CG  1 
ATOM   1823 O  OD1 . ASN A 1 337 ? 25.20922 15.01925  -39.63279  1.000 14.53142  ? 295 ASN A OD1 1 
ATOM   1824 N  ND2 . ASN A 1 337 ? 26.32239 13.26950  -40.51626  1.000 22.83496  ? 295 ASN A ND2 1 
ATOM   1825 N  N   . TRP A 1 338 ? 23.06914 10.47080  -38.16094  1.000 11.20303  ? 296 TRP A N   1 
ATOM   1826 C  CA  . TRP A 1 338 ? 22.75560 9.12514   -38.63537  1.000 14.61680  ? 296 TRP A CA  1 
ATOM   1827 C  C   . TRP A 1 338 ? 21.32158 8.99943   -39.16536  1.000 16.49696  ? 296 TRP A C   1 
ATOM   1828 O  O   . TRP A 1 338 ? 21.11505 8.71018   -40.34511  1.000 16.21535  ? 296 TRP A O   1 
ATOM   1829 C  CB  . TRP A 1 338 ? 22.98269 8.16823   -37.46897  1.000 14.27308  ? 296 TRP A CB  1 
ATOM   1830 C  CG  . TRP A 1 338 ? 22.63463 6.72663   -37.69349  1.000 14.86642  ? 296 TRP A CG  1 
ATOM   1831 C  CD1 . TRP A 1 338 ? 22.36570 6.10845   -38.88207  1.000 12.62461  ? 296 TRP A CD1 1 
ATOM   1832 C  CD2 . TRP A 1 338 ? 22.56521 5.72978   -36.68564  1.000 13.51813  ? 296 TRP A CD2 1 
ATOM   1833 N  NE1 . TRP A 1 338 ? 22.10542 4.76264   -38.65738  1.000 16.42477  ? 296 TRP A NE1 1 
ATOM   1834 C  CE2 . TRP A 1 338 ? 22.24471 4.50655   -37.32061  1.000 17.70155  ? 296 TRP A CE2 1 
ATOM   1835 C  CE3 . TRP A 1 338 ? 22.74510 5.74536   -35.30489  1.000 15.61949  ? 296 TRP A CE3 1 
ATOM   1836 C  CZ2 . TRP A 1 338 ? 22.07503 3.31249   -36.61505  1.000 17.33578  ? 296 TRP A CZ2 1 
ATOM   1837 C  CZ3 . TRP A 1 338 ? 22.61004 4.53243   -34.60019  1.000 17.65439  ? 296 TRP A CZ3 1 
ATOM   1838 C  CH2 . TRP A 1 338 ? 22.25069 3.34307   -35.25930  1.000 17.87310  ? 296 TRP A CH2 1 
ATOM   1839 N  N   . HIS A 1 339 ? 20.32359 9.22840   -38.31706  1.000 19.70054  ? 297 HIS A N   1 
ATOM   1840 C  CA  . HIS A 1 339 ? 18.93587 8.95145   -38.71314  1.000 20.64702  ? 297 HIS A CA  1 
ATOM   1841 C  C   . HIS A 1 339 ? 17.92317 9.69716   -37.82717  1.000 20.87106  ? 297 HIS A C   1 
ATOM   1842 O  O   . HIS A 1 339 ? 16.89464 9.13112   -37.40122  1.000 17.11392  ? 297 HIS A O   1 
ATOM   1843 C  CB  . HIS A 1 339 ? 18.71637 7.43801   -38.66072  1.000 12.17949  ? 297 HIS A CB  1 
ATOM   1844 C  CG  . HIS A 1 339 ? 18.94607 6.86885   -37.29971  1.000 15.73819  ? 297 HIS A CG  1 
ATOM   1845 N  ND1 . HIS A 1 339 ? 19.06095 5.51440   -37.06135  1.000 18.83004  ? 297 HIS A ND1 1 
ATOM   1846 C  CD2 . HIS A 1 339 ? 19.08048 7.47579   -36.09255  1.000 19.84238  ? 297 HIS A CD2 1 
ATOM   1847 C  CE1 . HIS A 1 339 ? 19.23920 5.31376   -35.76546  1.000 17.68050  ? 297 HIS A CE1 1 
ATOM   1848 N  NE2 . HIS A 1 339 ? 19.24674 6.48513   -35.15390  1.000 18.76477  ? 297 HIS A NE2 1 
ATOM   1849 N  N   . GLY A 1 340 ? 18.22323 10.96667  -37.51299  1.000 16.98686  ? 298 GLY A N   1 
ATOM   1850 C  CA  . GLY A 1 340 ? 17.35759 11.78474  -36.67916  1.000 17.15461  ? 298 GLY A CA  1 
ATOM   1851 C  C   . GLY A 1 340 ? 17.19600 13.20192  -37.21618  1.000 25.61851  ? 298 GLY A C   1 
ATOM   1852 O  O   . GLY A 1 340 ? 18.19808 13.91063  -37.38791  1.000 18.97107  ? 298 GLY A O   1 
ATOM   1853 N  N   . SER A 1 341 ? 15.93656 13.60071  -37.51877  1.000 16.61045  ? 299 SER A N   1 
ATOM   1854 C  CA  . SER A 1 341 ? 15.53505 14.94524  -37.93381  1.000 15.15518  ? 299 SER A CA  1 
ATOM   1855 C  C   . SER A 1 341 ? 15.12185 15.84113  -36.76395  1.000 21.81315  ? 299 SER A C   1 
ATOM   1856 O  O   . SER A 1 341 ? 15.02478 17.08440  -36.92179  1.000 18.12870  ? 299 SER A O   1 
ATOM   1857 C  CB  . SER A 1 341 ? 14.36061 14.83031  -38.91004  1.000 22.27320  ? 299 SER A CB  1 
ATOM   1858 O  OG  . SER A 1 341 ? 14.81986 14.76010  -40.23893  1.000 25.72845  ? 299 SER A OG  1 
ATOM   1859 N  N   . ASN A 1 342 ? 14.88395 15.23726  -35.60392  1.000 17.34821  ? 300 ASN A N   1 
ATOM   1860 C  CA  . ASN A 1 342 ? 14.80248 15.91420  -34.32300  1.000 13.71603  ? 300 ASN A CA  1 
ATOM   1861 C  C   . ASN A 1 342 ? 16.14686 15.75388  -33.60755  1.000 23.22067  ? 300 ASN A C   1 
ATOM   1862 O  O   . ASN A 1 342 ? 16.98151 14.93407  -34.00130  1.000 20.08595  ? 300 ASN A O   1 
ATOM   1863 C  CB  . ASN A 1 342 ? 13.64066 15.33600  -33.49169  1.000 11.51597  ? 300 ASN A CB  1 
ATOM   1864 C  CG  . ASN A 1 342 ? 13.71427 13.81382  -33.32869  1.000 17.34815  ? 300 ASN A CG  1 
ATOM   1865 O  OD1 . ASN A 1 342 ? 14.33406 13.13301  -34.13574  1.000 16.69052  ? 300 ASN A OD1 1 
ATOM   1866 N  ND2 . ASN A 1 342 ? 13.08435 13.28783  -32.27767  1.000 14.92308  ? 300 ASN A ND2 1 
ATOM   1867 N  N   . ARG A 1 343 ? 16.33913 16.53102  -32.52240  1.000 15.16986  ? 301 ARG A N   1 
ATOM   1868 C  CA  . ARG A 1 343 ? 17.67206 16.50352  -31.93281  1.000 21.75905  ? 301 ARG A CA  1 
ATOM   1869 C  C   . ARG A 1 343 ? 17.73244 15.59444  -30.71401  1.000 21.24044  ? 301 ARG A C   1 
ATOM   1870 O  O   . ARG A 1 343 ? 16.77920 15.54988  -29.91097  1.000 15.82720  ? 301 ARG A O   1 
ATOM   1871 C  CB  . ARG A 1 343 ? 18.11298 17.91139  -31.50999  1.000 20.69570  ? 301 ARG A CB  1 
ATOM   1872 C  CG  . ARG A 1 343 ? 18.22110 18.86795  -32.66030  1.000 14.58495  ? 301 ARG A CG  1 
ATOM   1873 C  CD  . ARG A 1 343 ? 18.97952 20.15279  -32.25533  1.000 15.85376  ? 301 ARG A CD  1 
ATOM   1874 N  NE  . ARG A 1 343 ? 19.21793 20.95509  -33.44193  1.000 15.46862  ? 301 ARG A NE  1 
ATOM   1875 C  CZ  . ARG A 1 343 ? 20.18712 20.74057  -34.31919  1.000 19.61305  ? 301 ARG A CZ  1 
ATOM   1876 N  NH1 . ARG A 1 343 ? 21.11172 19.80568  -34.11930  1.000 17.93752  ? 301 ARG A NH1 1 
ATOM   1877 N  NH2 . ARG A 1 343 ? 20.23538 21.48525  -35.42362  1.000 17.73790  ? 301 ARG A NH2 1 
ATOM   1878 N  N   . PRO A 1 344 ? 18.85908 14.89805  -30.60631  1.000 20.49009  ? 302 PRO A N   1 
ATOM   1879 C  CA  . PRO A 1 344 ? 19.16276 14.14047  -29.39082  1.000 19.90117  ? 302 PRO A CA  1 
ATOM   1880 C  C   . PRO A 1 344 ? 19.61381 15.04295  -28.26352  1.000 21.02420  ? 302 PRO A C   1 
ATOM   1881 O  O   . PRO A 1 344 ? 20.22190 16.09204  -28.48439  1.000 19.05677  ? 302 PRO A O   1 
ATOM   1882 C  CB  . PRO A 1 344 ? 20.32288 13.24344  -29.82882  1.000 18.28498  ? 302 PRO A CB  1 
ATOM   1883 C  CG  . PRO A 1 344 ? 21.02877 14.10188  -30.87600  1.000 14.86895  ? 302 PRO A CG  1 
ATOM   1884 C  CD  . PRO A 1 344 ? 19.92989 14.78516  -31.62308  1.000 17.09905  ? 302 PRO A CD  1 
ATOM   1885 N  N   . TRP A 1 345 ? 19.35908 14.59716  -27.03732  1.000 18.98409  ? 303 TRP A N   1 
ATOM   1886 C  CA  . TRP A 1 345 ? 19.89256 15.27835  -25.86897  1.000 14.91436  ? 303 TRP A CA  1 
ATOM   1887 C  C   . TRP A 1 345 ? 20.44838 14.27030  -24.87501  1.000 16.83574  ? 303 TRP A C   1 
ATOM   1888 O  O   . TRP A 1 345 ? 20.09596 13.08125  -24.88088  1.000 17.94026  ? 303 TRP A O   1 
ATOM   1889 C  CB  . TRP A 1 345 ? 18.84163 16.17543  -25.19643  1.000 21.28036  ? 303 TRP A CB  1 
ATOM   1890 C  CG  . TRP A 1 345 ? 17.63265 15.47666  -24.75728  1.000 19.80953  ? 303 TRP A CG  1 
ATOM   1891 C  CD1 . TRP A 1 345 ? 16.45481 15.36955  -25.44298  1.000 21.65830  ? 303 TRP A CD1 1 
ATOM   1892 C  CD2 . TRP A 1 345 ? 17.44330 14.78992  -23.51409  1.000 21.62019  ? 303 TRP A CD2 1 
ATOM   1893 N  NE1 . TRP A 1 345 ? 15.53796 14.65593  -24.70092  1.000 19.90987  ? 303 TRP A NE1 1 
ATOM   1894 C  CE2 . TRP A 1 345 ? 16.12053 14.27932  -23.51622  1.000 22.64049  ? 303 TRP A CE2 1 
ATOM   1895 C  CE3 . TRP A 1 345 ? 18.25431 14.55514  -22.40273  1.000 19.58128  ? 303 TRP A CE3 1 
ATOM   1896 C  CZ2 . TRP A 1 345 ? 15.60547 13.53338  -22.45567  1.000 23.09784  ? 303 TRP A CZ2 1 
ATOM   1897 C  CZ3 . TRP A 1 345 ? 17.74190 13.80011  -21.34162  1.000 21.64719  ? 303 TRP A CZ3 1 
ATOM   1898 C  CH2 . TRP A 1 345 ? 16.42226 13.30773  -21.37593  1.000 24.95451  ? 303 TRP A CH2 1 
ATOM   1899 N  N   . VAL A 1 346 ? 21.33601 14.76985  -24.01985  1.000 19.32089  ? 304 VAL A N   1 
ATOM   1900 C  CA  . VAL A 1 346 ? 21.90730 14.02052  -22.90785  1.000 18.14085  ? 304 VAL A CA  1 
ATOM   1901 C  C   . VAL A 1 346 ? 22.06118 15.01337  -21.77198  1.000 20.21512  ? 304 VAL A C   1 
ATOM   1902 O  O   . VAL A 1 346 ? 22.50606 16.14860  -21.99109  1.000 21.72385  ? 304 VAL A O   1 
ATOM   1903 C  CB  . VAL A 1 346 ? 23.26975 13.36568  -23.27524  1.000 14.42182  ? 304 VAL A CB  1 
ATOM   1904 C  CG1 . VAL A 1 346 ? 24.30555 14.42835  -23.74249  1.000 13.77421  ? 304 VAL A CG1 1 
ATOM   1905 C  CG2 . VAL A 1 346 ? 23.82509 12.58107  -22.13420  1.000 15.55372  ? 304 VAL A CG2 1 
ATOM   1906 N  N   . SER A 1 347 ? 21.64865 14.62494  -20.57951  1.000 16.69124  ? 305 SER A N   1 
ATOM   1907 C  CA  . SER A 1 347 ? 21.80544 15.47048  -19.41293  1.000 17.17972  ? 305 SER A CA  1 
ATOM   1908 C  C   . SER A 1 347 ? 22.51946 14.66886  -18.34544  1.000 22.62272  ? 305 SER A C   1 
ATOM   1909 O  O   . SER A 1 347 ? 22.40098 13.44117  -18.31638  1.000 23.89382  ? 305 SER A O   1 
ATOM   1910 C  CB  . SER A 1 347 ? 20.47261 15.98315  -18.89732  1.000 21.75577  ? 305 SER A CB  1 
ATOM   1911 O  OG  . SER A 1 347 ? 19.61020 14.90046  -18.62164  1.000 31.17832  ? 305 SER A OG  1 
ATOM   1912 N  N   . PHE A 1 348 ? 23.30337 15.34866  -17.49770  1.000 20.99859  ? 306 PHE A N   1 
ATOM   1913 C  CA  . PHE A 1 348 ? 24.04421 14.60751  -16.48274  1.000 21.02865  ? 306 PHE A CA  1 
ATOM   1914 C  C   . PHE A 1 348 ? 24.36076 15.50395  -15.29834  1.000 21.55117  ? 306 PHE A C   1 
ATOM   1915 O  O   . PHE A 1 348 ? 24.35835 16.73030  -15.40419  1.000 21.22712  ? 306 PHE A O   1 
ATOM   1916 C  CB  . PHE A 1 348 ? 25.32203 13.98348  -17.06478  1.000 24.60412  ? 306 PHE A CB  1 
ATOM   1917 C  CG  . PHE A 1 348 ? 26.14831 14.93411  -17.88483  1.000 20.93453  ? 306 PHE A CG  1 
ATOM   1918 C  CD1 . PHE A 1 348 ? 25.90104 15.08772  -19.24933  1.000 18.42633  ? 306 PHE A CD1 1 
ATOM   1919 C  CD2 . PHE A 1 348 ? 27.18511 15.65421  -17.30065  1.000 20.38180  ? 306 PHE A CD2 1 
ATOM   1920 C  CE1 . PHE A 1 348 ? 26.65192 15.94567  -20.01116  1.000 19.71895  ? 306 PHE A CE1 1 
ATOM   1921 C  CE2 . PHE A 1 348 ? 27.96509 16.53349  -18.06840  1.000 19.59777  ? 306 PHE A CE2 1 
ATOM   1922 C  CZ  . PHE A 1 348 ? 27.69881 16.67244  -19.42656  1.000 19.39357  ? 306 PHE A CZ  1 
ATOM   1923 N  N   . ASN A 1 349 ? 24.61195 14.86702  -14.15124  1.000 24.59458  ? 307 ASN A N   1 
ATOM   1924 C  CA  . ASN A 1 349 ? 25.04261 15.60112  -12.97632  1.000 27.26636  ? 307 ASN A CA  1 
ATOM   1925 C  C   . ASN A 1 349 ? 26.58748 15.62197  -12.89160  1.000 25.37802  ? 307 ASN A C   1 
ATOM   1926 O  O   . ASN A 1 349 ? 27.30282 15.10245  -13.75113  1.000 22.55797  ? 307 ASN A O   1 
ATOM   1927 C  CB  . ASN A 1 349 ? 24.40683 14.99554  -11.71943  1.000 22.90159  ? 307 ASN A CB  1 
ATOM   1928 C  CG  . ASN A 1 349 ? 24.86980 13.55969  -11.45417  1.000 26.52868  ? 307 ASN A CG  1 
ATOM   1929 O  OD1 . ASN A 1 349 ? 25.89167 13.12894  -11.96530  1.000 23.04741  ? 307 ASN A OD1 1 
ATOM   1930 N  ND2 . ASN A 1 349 ? 24.13923 12.84067  -10.61052  1.000 22.83383  ? 307 ASN A ND2 1 
ATOM   1931 N  N   . GLN A 1 350 ? 27.11333 16.22724  -11.82990  1.000 24.23697  ? 308 GLN A N   1 
ATOM   1932 C  CA  . GLN A 1 350 ? 28.55698 16.39063  -11.69162  1.000 26.40209  ? 308 GLN A CA  1 
ATOM   1933 C  C   . GLN A 1 350 ? 29.29980 15.06698  -11.54522  1.000 29.44421  ? 308 GLN A C   1 
ATOM   1934 O  O   . GLN A 1 350 ? 30.52808 15.03883  -11.71194  1.000 31.00399  ? 308 GLN A O   1 
ATOM   1935 C  CB  . GLN A 1 350 ? 28.82770 17.31797  -10.51137  1.000 20.06729  ? 308 GLN A CB  1 
ATOM   1936 C  CG  . GLN A 1 350 ? 28.30099 18.72624  -10.85872  1.000 43.64002  ? 308 GLN A CG  1 
ATOM   1937 C  CD  . GLN A 1 350 ? 28.35764 19.73200  -9.71915   1.000 44.29957  ? 308 GLN A CD  1 
ATOM   1938 O  OE1 . GLN A 1 350 ? 29.45041 20.12090  -9.27263   1.000 39.90001  ? 308 GLN A OE1 1 
ATOM   1939 N  NE2 . GLN A 1 350 ? 27.18279 20.22351  -9.29834   1.000 40.41623  ? 308 GLN A NE2 1 
ATOM   1940 N  N   . ASN A 1 351 ? 28.58493 13.97844  -11.26154  1.000 25.82672  ? 309 ASN A N   1 
ATOM   1941 C  CA  . ASN A 1 351 ? 29.14469 12.63893  -11.18576  1.000 23.92846  ? 309 ASN A CA  1 
ATOM   1942 C  C   . ASN A 1 351 ? 28.96822 11.85878  -12.48804  1.000 27.91052  ? 309 ASN A C   1 
ATOM   1943 O  O   . ASN A 1 351 ? 29.22760 10.65501  -12.51930  1.000 25.61987  ? 309 ASN A O   1 
ATOM   1944 C  CB  . ASN A 1 351 ? 28.51814 11.89506  -10.00848  1.000 25.90208  ? 309 ASN A CB  1 
ATOM   1945 C  CG  . ASN A 1 351 ? 29.33259 10.70755  -9.57513   1.000 52.28626  ? 309 ASN A CG  1 
ATOM   1946 O  OD1 . ASN A 1 351 ? 28.78860 9.65228   -9.21007   1.000 55.71577  ? 309 ASN A OD1 1 
ATOM   1947 N  ND2 . ASN A 1 351 ? 30.65543 10.85651  -9.62837   1.000 51.76525  ? 309 ASN A ND2 1 
ATOM   1948 N  N   . LEU A 1 352 ? 28.51816 12.51495  -13.55857  1.000 23.85935  ? 310 LEU A N   1 
ATOM   1949 C  CA  . LEU A 1 352 ? 28.37524 11.92826  -14.89262  1.000 19.70864  ? 310 LEU A CA  1 
ATOM   1950 C  C   . LEU A 1 352 ? 27.33031 10.81612  -14.93170  1.000 23.43797  ? 310 LEU A C   1 
ATOM   1951 O  O   . LEU A 1 352 ? 27.34217 9.98271   -15.84022  1.000 28.89377  ? 310 LEU A O   1 
ATOM   1952 C  CB  . LEU A 1 352 ? 29.72668 11.41810  -15.43299  1.000 21.02935  ? 310 LEU A CB  1 
ATOM   1953 C  CG  . LEU A 1 352 ? 30.81944 12.48615  -15.55946  1.000 23.03174  ? 310 LEU A CG  1 
ATOM   1954 C  CD1 . LEU A 1 352 ? 32.07915 11.95032  -16.30417  1.000 23.26406  ? 310 LEU A CD1 1 
ATOM   1955 C  CD2 . LEU A 1 352 ? 30.27549 13.84970  -16.18871  1.000 15.85181  ? 310 LEU A CD2 1 
ATOM   1956 N  N   . GLU A 1 353 ? 26.41779 10.79298  -13.96691  1.000 29.00578  ? 311 GLU A N   1 
ATOM   1957 C  CA  . GLU A 1 353 ? 25.18674 10.02184  -14.11405  1.000 24.19765  ? 311 GLU A CA  1 
ATOM   1958 C  C   . GLU A 1 353 ? 24.28515 10.77246  -15.07236  1.000 23.67520  ? 311 GLU A C   1 
ATOM   1959 O  O   . GLU A 1 353 ? 23.98594 11.94820  -14.85164  1.000 22.90993  ? 311 GLU A O   1 
ATOM   1960 C  CB  . GLU A 1 353 ? 24.51393 9.85350   -12.76352  1.000 25.16277  ? 311 GLU A CB  1 
ATOM   1961 C  CG  . GLU A 1 353 ? 25.28908 8.96055   -11.81916  1.000 30.37832  ? 311 GLU A CG  1 
ATOM   1962 C  CD  . GLU A 1 353 ? 25.24060 9.41795   -10.37068  1.000 42.28285  ? 311 GLU A CD  1 
ATOM   1963 O  OE1 . GLU A 1 353 ? 24.34926 10.20803  -10.00305  1.000 40.05747  ? 311 GLU A OE1 1 
ATOM   1964 O  OE2 . GLU A 1 353 ? 26.10073 8.96278   -9.58827   1.000 57.32779  ? 311 GLU A OE2 1 
ATOM   1965 N  N   . TYR A 1 354 ? 23.88981 10.12265  -16.15037  1.000 20.60373  ? 312 TYR A N   1 
ATOM   1966 C  CA  . TYR A 1 354 ? 23.27717 10.80636  -17.28101  1.000 24.09360  ? 312 TYR A CA  1 
ATOM   1967 C  C   . TYR A 1 354 ? 21.92587 10.20340  -17.63849  1.000 24.28051  ? 312 TYR A C   1 
ATOM   1968 O  O   . TYR A 1 354 ? 21.59987 9.07890   -17.25967  1.000 18.09139  ? 312 TYR A O   1 
ATOM   1969 C  CB  . TYR A 1 354 ? 24.19251 10.74255  -18.51902  1.000 26.07427  ? 312 TYR A CB  1 
ATOM   1970 C  CG  . TYR A 1 354 ? 24.43175 9.32296   -18.98816  1.000 19.09865  ? 312 TYR A CG  1 
ATOM   1971 C  CD1 . TYR A 1 354 ? 23.60676 8.73013   -19.93980  1.000 30.81860  ? 312 TYR A CD1 1 
ATOM   1972 C  CD2 . TYR A 1 354 ? 25.45740 8.56874   -18.45986  1.000 24.22192  ? 312 TYR A CD2 1 
ATOM   1973 C  CE1 . TYR A 1 354 ? 23.82039 7.39731   -20.36437  1.000 27.41033  ? 312 TYR A CE1 1 
ATOM   1974 C  CE2 . TYR A 1 354 ? 25.69382 7.24922   -18.88464  1.000 31.66981  ? 312 TYR A CE2 1 
ATOM   1975 C  CZ  . TYR A 1 354 ? 24.86389 6.66711   -19.82197  1.000 31.74524  ? 312 TYR A CZ  1 
ATOM   1976 O  OH  . TYR A 1 354 ? 25.09862 5.37203   -20.24080  1.000 25.19850  ? 312 TYR A OH  1 
ATOM   1977 N  N   . GLN A 1 355 ? 21.14068 10.97688  -18.38299  1.000 23.38852  ? 313 GLN A N   1 
ATOM   1978 C  CA  . GLN A 1 355 ? 19.93688 10.49942  -19.03927  1.000 25.19985  ? 313 GLN A CA  1 
ATOM   1979 C  C   . GLN A 1 355 ? 19.99854 10.92882  -20.48887  1.000 23.62745  ? 313 GLN A C   1 
ATOM   1980 O  O   . GLN A 1 355 ? 20.69977 11.88052  -20.83587  1.000 21.86761  ? 313 GLN A O   1 
ATOM   1981 C  CB  . GLN A 1 355 ? 18.66166 11.05142  -18.40210  1.000 21.46735  ? 313 GLN A CB  1 
ATOM   1982 C  CG  . GLN A 1 355 ? 18.55559 10.83381  -16.91742  1.000 27.89152  ? 313 GLN A CG  1 
ATOM   1983 C  CD  . GLN A 1 355 ? 17.30302 11.49728  -16.35131  1.000 58.42094  ? 313 GLN A CD  1 
ATOM   1984 O  OE1 . GLN A 1 355 ? 17.37263 12.61466  -15.81992  1.000 51.74278  ? 313 GLN A OE1 1 
ATOM   1985 N  NE2 . GLN A 1 355 ? 16.14523 10.83072  -16.49255  1.000 48.08383  ? 313 GLN A NE2 1 
ATOM   1986 N  N   . ILE A 1 356 ? 19.26166 10.21728  -21.33706  1.000 14.88039  ? 314 ILE A N   1 
ATOM   1987 C  CA  . ILE A 1 356 ? 19.25668 10.48880  -22.76561  1.000 13.91037  ? 314 ILE A CA  1 
ATOM   1988 C  C   . ILE A 1 356 ? 17.83287 10.46175  -23.31357  1.000 22.56738  ? 314 ILE A C   1 
ATOM   1989 O  O   . ILE A 1 356 ? 16.92952 9.84096   -22.75027  1.000 24.41481  ? 314 ILE A O   1 
ATOM   1990 C  CB  . ILE A 1 356 ? 20.11480 9.48057   -23.55601  1.000 19.73410  ? 314 ILE A CB  1 
ATOM   1991 C  CG1 . ILE A 1 356 ? 19.64757 8.04328   -23.27909  1.000 17.86917  ? 314 ILE A CG1 1 
ATOM   1992 C  CG2 . ILE A 1 356 ? 21.61133 9.68119   -23.23775  1.000 18.47605  ? 314 ILE A CG2 1 
ATOM   1993 C  CD1 . ILE A 1 356 ? 20.34454 7.01114   -24.17959  1.000 18.94817  ? 314 ILE A CD1 1 
ATOM   1994 N  N   . GLY A 1 357 ? 17.66888 11.08640  -24.47474  1.000 20.77313  ? 315 GLY A N   1 
ATOM   1995 C  CA  . GLY A 1 357 ? 16.40203 11.05382  -25.18192  1.000 26.37467  ? 315 GLY A CA  1 
ATOM   1996 C  C   . GLY A 1 357 ? 16.50317 11.91850  -26.41761  1.000 25.46486  ? 315 GLY A C   1 
ATOM   1997 O  O   . GLY A 1 357 ? 17.56898 12.45990  -26.72870  1.000 22.38717  ? 315 GLY A O   1 
ATOM   1998 N  N   . TYR A 1 358 ? 15.37135 12.08654  -27.09494  1.000 18.31571  ? 316 TYR A N   1 
ATOM   1999 C  CA  . TYR A 1 358 ? 15.24769 13.02772  -28.20628  1.000 19.34502  ? 316 TYR A CA  1 
ATOM   2000 C  C   . TYR A 1 358 ? 14.14515 14.04103  -27.90174  1.000 21.04429  ? 316 TYR A C   1 
ATOM   2001 O  O   . TYR A 1 358 ? 13.16141 13.71737  -27.21623  1.000 17.13239  ? 316 TYR A O   1 
ATOM   2002 C  CB  . TYR A 1 358 ? 14.92124 12.31692  -29.53089  1.000 17.38957  ? 316 TYR A CB  1 
ATOM   2003 C  CG  . TYR A 1 358 ? 16.09565 11.69013  -30.24872  1.000 27.53735  ? 316 TYR A CG  1 
ATOM   2004 C  CD1 . TYR A 1 358 ? 16.67413 10.50616  -29.77967  1.000 24.15174  ? 316 TYR A CD1 1 
ATOM   2005 C  CD2 . TYR A 1 358 ? 16.62781 12.26867  -31.40322  1.000 20.68353  ? 316 TYR A CD2 1 
ATOM   2006 C  CE1 . TYR A 1 358 ? 17.76092 9.91547   -30.43839  1.000 23.11853  ? 316 TYR A CE1 1 
ATOM   2007 C  CE2 . TYR A 1 358 ? 17.69866 11.66797  -32.08030  1.000 16.11167  ? 316 TYR A CE2 1 
ATOM   2008 C  CZ  . TYR A 1 358 ? 18.25936 10.50281  -31.56978  1.000 19.86799  ? 316 TYR A CZ  1 
ATOM   2009 O  OH  . TYR A 1 358 ? 19.30727 9.90869   -32.20833  1.000 17.56071  ? 316 TYR A OH  1 
ATOM   2010 N  N   . ILE A 1 359 ? 14.29495 15.24942  -28.45343  1.000 20.38213  ? 317 ILE A N   1 
ATOM   2011 C  CA  . ILE A 1 359 ? 13.25691 16.27060  -28.28763  1.000 18.79266  ? 317 ILE A CA  1 
ATOM   2012 C  C   . ILE A 1 359 ? 12.02014 15.79268  -29.03859  1.000 16.68072  ? 317 ILE A C   1 
ATOM   2013 O  O   . ILE A 1 359 ? 12.08164 15.48946  -30.23408  1.000 17.52665  ? 317 ILE A O   1 
ATOM   2014 C  CB  . ILE A 1 359 ? 13.72561 17.65493  -28.77416  1.000 18.45891  ? 317 ILE A CB  1 
ATOM   2015 C  CG1 . ILE A 1 359 ? 14.88719 18.15912  -27.92964  1.000 17.00653  ? 317 ILE A CG1 1 
ATOM   2016 C  CG2 . ILE A 1 359 ? 12.58528 18.65613  -28.63982  1.000 12.58358  ? 317 ILE A CG2 1 
ATOM   2017 C  CD1 . ILE A 1 359 ? 15.51699 19.49839  -28.45616  1.000 15.83906  ? 317 ILE A CD1 1 
ATOM   2018 N  N   . CYS A 1 360 ? 10.89817 15.67521  -28.32078  1.000 22.79016  ? 318 CYS A N   1 
ATOM   2019 C  CA  . CYS A 1 360 ? 9.67171  15.04002  -28.82606  1.000 20.47319  ? 318 CYS A CA  1 
ATOM   2020 C  C   . CYS A 1 360 ? 8.87337  15.91225  -29.78079  1.000 24.39854  ? 318 CYS A C   1 
ATOM   2021 O  O   . CYS A 1 360 ? 8.08735  15.37975  -30.59049  1.000 18.86460  ? 318 CYS A O   1 
ATOM   2022 C  CB  . CYS A 1 360 ? 8.77643  14.66891  -27.64354  1.000 21.93061  ? 318 CYS A CB  1 
ATOM   2023 S  SG  . CYS A 1 360 ? 9.58075  13.49934  -26.47581  1.000 28.20554  ? 318 CYS A SG  1 
ATOM   2024 N  N   . SER A 1 361 ? 9.05127  17.23440  -29.70407  1.000 14.71244  ? 319 SER A N   1 
ATOM   2025 C  CA  . SER A 1 361 ? 8.20228  18.14729  -30.45999  1.000 18.82662  ? 319 SER A CA  1 
ATOM   2026 C  C   . SER A 1 361 ? 8.13425  17.75119  -31.92153  1.000 20.59377  ? 319 SER A C   1 
ATOM   2027 O  O   . SER A 1 361 ? 9.13359  17.32981  -32.50554  1.000 17.35361  ? 319 SER A O   1 
ATOM   2028 C  CB  . SER A 1 361 ? 8.72121  19.58078  -30.34909  1.000 19.50619  ? 319 SER A CB  1 
ATOM   2029 O  OG  . SER A 1 361 ? 8.05913  20.39177  -31.29916  1.000 20.28044  ? 319 SER A OG  1 
ATOM   2030 N  N   . GLY A 1 362 ? 6.93349  17.87962  -32.51164  1.000 17.90923  ? 320 GLY A N   1 
ATOM   2031 C  CA  . GLY A 1 362 ? 6.84409  17.75978  -33.95586  1.000 16.22885  ? 320 GLY A CA  1 
ATOM   2032 C  C   . GLY A 1 362 ? 7.39806  18.94274  -34.72024  1.000 21.67687  ? 320 GLY A C   1 
ATOM   2033 O  O   . GLY A 1 362 ? 7.34527  18.93585  -35.95593  1.000 20.18408  ? 320 GLY A O   1 
ATOM   2034 N  N   . ILE A 1 363 ? 7.89658  19.95972  -34.00667  1.000 17.45621  ? 321 ILE A N   1 
ATOM   2035 C  CA  . ILE A 1 363 ? 8.64241  21.08412  -34.58718  1.000 22.26876  ? 321 ILE A CA  1 
ATOM   2036 C  C   . ILE A 1 363 ? 10.09289 20.60880  -34.66996  1.000 22.87645  ? 321 ILE A C   1 
ATOM   2037 O  O   . ILE A 1 363 ? 10.88975 20.86048  -33.77419  1.000 20.65117  ? 321 ILE A O   1 
ATOM   2038 C  CB  . ILE A 1 363 ? 8.52230  22.35119  -33.72864  1.000 18.12038  ? 321 ILE A CB  1 
ATOM   2039 C  CG1 . ILE A 1 363 ? 7.06278  22.72854  -33.41275  1.000 17.42620  ? 321 ILE A CG1 1 
ATOM   2040 C  CG2 . ILE A 1 363 ? 9.29676  23.53891  -34.36844  1.000 25.62195  ? 321 ILE A CG2 1 
ATOM   2041 C  CD1 . ILE A 1 363 ? 6.28418  23.17889  -34.62053  1.000 26.44360  ? 321 ILE A CD1 1 
ATOM   2042 N  N   . PHE A 1 364 ? 10.43967 19.90913  -35.75257  1.000 20.30989  ? 322 PHE A N   1 
ATOM   2043 C  CA  . PHE A 1 364 ? 11.73373 19.24462  -35.83049  1.000 19.40949  ? 322 PHE A CA  1 
ATOM   2044 C  C   . PHE A 1 364 ? 12.86223 20.26585  -35.92077  1.000 19.89175  ? 322 PHE A C   1 
ATOM   2045 O  O   . PHE A 1 364 ? 12.79873 21.21383  -36.71551  1.000 15.63395  ? 322 PHE A O   1 
ATOM   2046 C  CB  . PHE A 1 364 ? 11.76647 18.33462  -37.04504  1.000 19.32613  ? 322 PHE A CB  1 
ATOM   2047 C  CG  . PHE A 1 364 ? 10.63534 17.39540  -37.09331  1.000 20.59834  ? 322 PHE A CG  1 
ATOM   2048 C  CD1 . PHE A 1 364 ? 10.45708 16.48153  -36.09812  1.000 19.92116  ? 322 PHE A CD1 1 
ATOM   2049 C  CD2 . PHE A 1 364 ? 9.70525  17.45967  -38.12361  1.000 23.78250  ? 322 PHE A CD2 1 
ATOM   2050 C  CE1 . PHE A 1 364 ? 9.38864  15.59968  -36.14811  1.000 20.25421  ? 322 PHE A CE1 1 
ATOM   2051 C  CE2 . PHE A 1 364 ? 8.64449  16.57098  -38.18244  1.000 20.66258  ? 322 PHE A CE2 1 
ATOM   2052 C  CZ  . PHE A 1 364 ? 8.47437  15.66425  -37.18377  1.000 19.14071  ? 322 PHE A CZ  1 
ATOM   2053 N  N   . GLY A 1 365 ? 13.92846 20.02711  -35.15842  1.000 16.01289  ? 323 GLY A N   1 
ATOM   2054 C  CA  . GLY A 1 365 ? 14.94628 21.06231  -35.00215  1.000 17.98183  ? 323 GLY A CA  1 
ATOM   2055 C  C   . GLY A 1 365 ? 16.16786 20.95865  -35.90237  1.000 19.93660  ? 323 GLY A C   1 
ATOM   2056 O  O   . GLY A 1 365 ? 16.97198 21.89671  -35.97366  1.000 15.40946  ? 323 GLY A O   1 
ATOM   2057 N  N   . ASP A 1 366 ? 16.34893 19.83241  -36.57311  1.000 11.61426  ? 324 ASP A N   1 
ATOM   2058 C  CA  . ASP A 1 366 ? 17.54937 19.64341  -37.37130  1.000 14.92090  ? 324 ASP A CA  1 
ATOM   2059 C  C   . ASP A 1 366 ? 17.31300 20.14455  -38.79357  1.000 19.04501  ? 324 ASP A C   1 
ATOM   2060 O  O   . ASP A 1 366 ? 16.20842 20.53731  -39.17497  1.000 20.50927  ? 324 ASP A O   1 
ATOM   2061 C  CB  . ASP A 1 366 ? 17.96036 18.15499  -37.36116  1.000 22.39788  ? 324 ASP A CB  1 
ATOM   2062 C  CG  . ASP A 1 366 ? 19.44970 17.92436  -37.62435  1.000 22.02848  ? 324 ASP A CG  1 
ATOM   2063 O  OD1 . ASP A 1 366 ? 20.22827 18.88881  -37.91004  1.000 20.35504  ? 324 ASP A OD1 1 
ATOM   2064 O  OD2 . ASP A 1 366 ? 19.85523 16.74486  -37.53639  1.000 16.40213  ? 324 ASP A OD2 1 
ATOM   2065 N  N   . ASN A 1 367 ? 18.38141 20.13244  -39.57640  1.000 17.60132  ? 325 ASN A N   1 
ATOM   2066 C  CA  . ASN A 1 367 ? 18.37243 20.45761  -40.99072  1.000 12.60982  ? 325 ASN A CA  1 
ATOM   2067 C  C   . ASN A 1 367 ? 19.31408 19.50354  -41.70245  1.000 17.16128  ? 325 ASN A C   1 
ATOM   2068 O  O   . ASN A 1 367 ? 20.50400 19.43516  -41.32942  1.000 18.50627  ? 325 ASN A O   1 
ATOM   2069 C  CB  . ASN A 1 367 ? 18.83763 21.88915  -41.24307  1.000 14.36572  ? 325 ASN A CB  1 
ATOM   2070 C  CG  . ASN A 1 367 ? 18.69843 22.29474  -42.68563  1.000 18.99195  ? 325 ASN A CG  1 
ATOM   2071 O  OD1 . ASN A 1 367 ? 19.66971 22.25761  -43.45763  1.000 19.19036  ? 325 ASN A OD1 1 
ATOM   2072 N  ND2 . ASN A 1 367 ? 17.47781 22.69616  -43.07141  1.000 15.21274  ? 325 ASN A ND2 1 
ATOM   2073 N  N   . PRO A 1 368 ? 18.84389 18.75901  -42.73326  1.000 16.77861  ? 326 PRO A N   1 
ATOM   2074 C  CA  . PRO A 1 368 ? 17.45909 18.69277  -43.27789  1.000 19.49993  ? 326 PRO A CA  1 
ATOM   2075 C  C   . PRO A 1 368 ? 16.46510 18.05184  -42.31642  1.000 19.62585  ? 326 PRO A C   1 
ATOM   2076 O  O   . PRO A 1 368 ? 16.84276 17.59024  -41.22918  1.000 14.67294  ? 326 PRO A O   1 
ATOM   2077 C  CB  . PRO A 1 368 ? 17.60715 17.83678  -44.54215  1.000 17.54800  ? 326 PRO A CB  1 
ATOM   2078 C  CG  . PRO A 1 368 ? 18.82108 16.93645  -44.22874  1.000 24.43683  ? 326 PRO A CG  1 
ATOM   2079 C  CD  . PRO A 1 368 ? 19.75182 17.80968  -43.41636  1.000 20.08623  ? 326 PRO A CD  1 
ATOM   2080 N  N   . ARG A 1 369 ? 15.18573 18.04661  -42.67429  1.000 19.56037  ? 327 ARG A N   1 
ATOM   2081 C  CA  . ARG A 1 369 ? 14.11206 17.60925  -41.79298  1.000 22.43472  ? 327 ARG A CA  1 
ATOM   2082 C  C   . ARG A 1 369 ? 12.84874 17.51441  -42.62013  1.000 17.37861  ? 327 ARG A C   1 
ATOM   2083 O  O   . ARG A 1 369 ? 12.83989 17.95580  -43.77510  1.000 19.03466  ? 327 ARG A O   1 
ATOM   2084 C  CB  . ARG A 1 369 ? 13.91004 18.55894  -40.60391  1.000 16.62062  ? 327 ARG A CB  1 
ATOM   2085 C  CG  . ARG A 1 369 ? 13.37784 19.95302  -40.96539  1.000 18.68498  ? 327 ARG A CG  1 
ATOM   2086 C  CD  . ARG A 1 369 ? 13.06242 20.76195  -39.70897  1.000 15.31294  ? 327 ARG A CD  1 
ATOM   2087 N  NE  . ARG A 1 369 ? 12.59308 22.10120  -40.03498  1.000 14.69164  ? 327 ARG A NE  1 
ATOM   2088 C  CZ  . ARG A 1 369 ? 13.37441 23.16144  -40.15687  1.000 19.21272  ? 327 ARG A CZ  1 
ATOM   2089 N  NH1 . ARG A 1 369 ? 14.66739 23.08804  -39.92684  1.000 16.21918  ? 327 ARG A NH1 1 
ATOM   2090 N  NH2 . ARG A 1 369 ? 12.84169 24.33440  -40.50445  1.000 15.67697  ? 327 ARG A NH2 1 
ATOM   2091 N  N   . PRO A 1 370 ? 11.81533 16.85353  -42.10330  1.000 17.61222  ? 328 PRO A N   1 
ATOM   2092 C  CA  . PRO A 1 370 ? 10.50494 16.90347  -42.76372  1.000 21.20655  ? 328 PRO A CA  1 
ATOM   2093 C  C   . PRO A 1 370 ? 9.76863  18.16254  -42.35525  1.000 24.23716  ? 328 PRO A C   1 
ATOM   2094 O  O   . PRO A 1 370 ? 10.17935 18.86968  -41.43021  1.000 15.90741  ? 328 PRO A O   1 
ATOM   2095 C  CB  . PRO A 1 370 ? 9.75879  15.65628  -42.25239  1.000 28.40428  ? 328 PRO A CB  1 
ATOM   2096 C  CG  . PRO A 1 370 ? 10.44297 15.25804  -41.00489  1.000 26.87423  ? 328 PRO A CG  1 
ATOM   2097 C  CD  . PRO A 1 370 ? 11.86077 15.81393  -41.04892  1.000 23.59093  ? 328 PRO A CD  1 
ATOM   2098 N  N   . ASN A 1 371 ? 8.65217  18.42225  -43.05583  1.000 22.07860  ? 329 ASN A N   1 
ATOM   2099 C  CA  . ASN A 1 371 ? 7.73046  19.44516  -42.58126  1.000 22.71064  ? 329 ASN A CA  1 
ATOM   2100 C  C   . ASN A 1 371 ? 7.18849  19.01211  -41.24016  1.000 22.01316  ? 329 ASN A C   1 
ATOM   2101 O  O   . ASN A 1 371 ? 7.06202  17.81770  -40.96021  1.000 21.38978  ? 329 ASN A O   1 
ATOM   2102 C  CB  . ASN A 1 371 ? 6.58262  19.66921  -43.55837  1.000 23.55466  ? 329 ASN A CB  1 
ATOM   2103 C  CG  . ASN A 1 371 ? 6.99077  20.52419  -44.73786  1.000 28.70810  ? 329 ASN A CG  1 
ATOM   2104 O  OD1 . ASN A 1 371 ? 6.99167  20.06755  -45.88557  1.000 35.24276  ? 329 ASN A OD1 1 
ATOM   2105 N  ND2 . ASN A 1 371 ? 7.32911  21.77009  -44.46626  1.000 30.92686  ? 329 ASN A ND2 1 
ATOM   2106 N  N   . ASP A 1 372 ? 6.85483  19.99586  -40.41591  1.000 19.30791  ? 330 ASP A N   1 
ATOM   2107 C  CA  . ASP A 1 372 ? 6.35014  19.69380  -39.09259  1.000 26.87496  ? 330 ASP A CA  1 
ATOM   2108 C  C   . ASP A 1 372 ? 5.09199  18.82726  -39.19182  1.000 23.46776  ? 330 ASP A C   1 
ATOM   2109 O  O   . ASP A 1 372 ? 4.28199  18.96845  -40.10926  1.000 17.42147  ? 330 ASP A O   1 
ATOM   2110 C  CB  . ASP A 1 372 ? 6.06595  20.98243  -38.32217  1.000 20.96076  ? 330 ASP A CB  1 
ATOM   2111 C  CG  . ASP A 1 372 ? 7.26714  21.93896  -38.31786  1.000 24.49357  ? 330 ASP A CG  1 
ATOM   2112 O  OD1 . ASP A 1 372 ? 7.02257  23.16435  -38.28052  1.000 29.55304  ? 330 ASP A OD1 1 
ATOM   2113 O  OD2 . ASP A 1 372 ? 8.43927  21.46750  -38.41105  1.000 22.39740  ? 330 ASP A OD2 1 
ATOM   2114 N  N   . LYS A 1 373 ? 4.99806  17.87583  -38.28256  1.000 20.74237  ? 331 LYS A N   1 
ATOM   2115 C  CA  . LYS A 1 373 ? 3.90004  16.92363  -38.13404  1.000 27.66384  ? 331 LYS A CA  1 
ATOM   2116 C  C   . LYS A 1 373 ? 4.15244  16.24540  -36.79761  1.000 27.43521  ? 331 LYS A C   1 
ATOM   2117 O  O   . LYS A 1 373 ? 5.09713  16.59713  -36.08108  1.000 28.33172  ? 331 LYS A O   1 
ATOM   2118 C  CB  . LYS A 1 373 ? 3.84142  15.94759  -39.31190  1.000 20.45639  ? 331 LYS A CB  1 
ATOM   2119 C  CG  . LYS A 1 373 ? 5.14319  15.14467  -39.49157  1.000 21.49982  ? 331 LYS A CG  1 
ATOM   2120 C  CD  . LYS A 1 373 ? 5.10967  14.12799  -40.65165  1.000 38.92002  ? 331 LYS A CD  1 
ATOM   2121 C  CE  . LYS A 1 373 ? 4.81275  14.80275  -42.00466  1.000 49.22155  ? 331 LYS A CE  1 
ATOM   2122 N  NZ  . LYS A 1 373 ? 5.89322  15.69784  -42.57863  1.000 33.54437  ? 331 LYS A NZ  1 
ATOM   2123 N  N   . THR A 1 374 ? 3.34996  15.25560  -36.46752  1.000 21.42843  ? 332 THR A N   1 
ATOM   2124 C  CA  . THR A 1 374 ? 3.54625  14.55624  -35.20841  1.000 17.30295  ? 332 THR A CA  1 
ATOM   2125 C  C   . THR A 1 374 ? 4.96732  14.02855  -35.11811  1.000 23.12777  ? 332 THR A C   1 
ATOM   2126 O  O   . THR A 1 374 ? 5.48576  13.42153  -36.06272  1.000 25.37267  ? 332 THR A O   1 
ATOM   2127 C  CB  . THR A 1 374 ? 2.53272  13.41541  -35.10354  1.000 31.27134  ? 332 THR A CB  1 
ATOM   2128 O  OG1 . THR A 1 374 ? 1.22908  14.00317  -35.09000  1.000 22.88124  ? 332 THR A OG1 1 
ATOM   2129 C  CG2 . THR A 1 374 ? 2.75112  12.62494  -33.83483  1.000 23.75808  ? 332 THR A CG2 1 
ATOM   2130 N  N   . GLY A 1 375 ? 5.60663  14.30331  -33.99134  1.000 18.41684  ? 333 GLY A N   1 
ATOM   2131 C  CA  . GLY A 1 375 ? 7.00919  14.01263  -33.80260  1.000 21.06680  ? 333 GLY A CA  1 
ATOM   2132 C  C   . GLY A 1 375 ? 7.17592  12.70998  -33.05710  1.000 29.17310  ? 333 GLY A C   1 
ATOM   2133 O  O   . GLY A 1 375 ? 6.25513  11.89034  -32.97601  1.000 26.31983  ? 333 GLY A O   1 
ATOM   2134 N  N   . SER A 1 376 ? 8.35505  12.52848  -32.47154  1.000 22.83161  ? 334 SER A N   1 
ATOM   2135 C  CA  . SER A 1 376 ? 8.64692  11.27718  -31.79366  1.000 24.30462  ? 334 SER A CA  1 
ATOM   2136 C  C   . SER A 1 376 ? 9.65680  11.53210  -30.69241  1.000 23.35883  ? 334 SER A C   1 
ATOM   2137 O  O   . SER A 1 376 ? 10.49919 12.43962  -30.78968  1.000 20.08866  ? 334 SER A O   1 
ATOM   2138 C  CB  . SER A 1 376 ? 9.16403  10.22506  -32.77503  1.000 23.50714  ? 334 SER A CB  1 
ATOM   2139 O  OG  . SER A 1 376 ? 9.80511  9.17255   -32.08353  1.000 32.91203  ? 334 SER A OG  1 
ATOM   2140 N  N   . CYS A 1 377 ? 9.58476  10.71000  -29.65119  1.000 20.96131  ? 335 CYS A N   1 
ATOM   2141 C  CA  . CYS A 1 377 ? 10.56852 10.81221  -28.57757  1.000 26.52885  ? 335 CYS A CA  1 
ATOM   2142 C  C   . CYS A 1 377 ? 11.81754 9.96410   -28.84737  1.000 23.88715  ? 335 CYS A C   1 
ATOM   2143 O  O   . CYS A 1 377 ? 12.71893 9.89447   -27.99949  1.000 22.71261  ? 335 CYS A O   1 
ATOM   2144 C  CB  . CYS A 1 377 ? 9.90788  10.45364  -27.24673  1.000 29.80615  ? 335 CYS A CB  1 
ATOM   2145 S  SG  . CYS A 1 377 ? 8.57481  11.67784  -26.77169  1.000 41.00328  ? 335 CYS A SG  1 
ATOM   2146 N  N   . GLY A 1 378 ? 11.89820 9.35649   -30.03039  1.000 20.33170  ? 336 GLY A N   1 
ATOM   2147 C  CA  . GLY A 1 378 ? 13.10706 8.73820   -30.49860  1.000 24.30048  ? 336 GLY A CA  1 
ATOM   2148 C  C   . GLY A 1 378 ? 13.48275 9.37998   -31.81624  1.000 27.81104  ? 336 GLY A C   1 
ATOM   2149 O  O   . GLY A 1 378 ? 12.87531 10.37058  -32.23534  1.000 27.27388  ? 336 GLY A O   1 
ATOM   2150 N  N   . PRO A 1 379 ? 14.47555 8.83730   -32.51051  1.000 19.57188  ? 337 PRO A N   1 
ATOM   2151 C  CA  . PRO A 1 379 ? 14.96273 9.53950   -33.70766  1.000 20.45596  ? 337 PRO A CA  1 
ATOM   2152 C  C   . PRO A 1 379 ? 13.93518 9.47126   -34.83622  1.000 28.61644  ? 337 PRO A C   1 
ATOM   2153 O  O   . PRO A 1 379 ? 13.38934 8.40824   -35.13606  1.000 22.74649  ? 337 PRO A O   1 
ATOM   2154 C  CB  . PRO A 1 379 ? 16.27902 8.82442   -34.05057  1.000 16.18689  ? 337 PRO A CB  1 
ATOM   2155 C  CG  . PRO A 1 379 ? 16.20734 7.43809   -33.29236  1.000 15.53768  ? 337 PRO A CG  1 
ATOM   2156 C  CD  . PRO A 1 379 ? 15.31001 7.67651   -32.10417  1.000 19.86234  ? 337 PRO A CD  1 
ATOM   2157 N  N   . VAL A 1 380 ? 13.64268 10.63362  -35.42505  1.000 20.09249  ? 338 VAL A N   1 
ATOM   2158 C  CA  . VAL A 1 380 ? 12.75259 10.74853  -36.58217  1.000 16.58435  ? 338 VAL A CA  1 
ATOM   2159 C  C   . VAL A 1 380 ? 13.59536 10.49180  -37.82227  1.000 20.75146  ? 338 VAL A C   1 
ATOM   2160 O  O   . VAL A 1 380 ? 14.41479 11.33011  -38.19988  1.000 16.62446  ? 338 VAL A O   1 
ATOM   2161 C  CB  . VAL A 1 380 ? 12.10381 12.14000  -36.63874  1.000 19.94618  ? 338 VAL A CB  1 
ATOM   2162 C  CG1 . VAL A 1 380 ? 11.33260 12.35461  -37.93408  1.000 15.63168  ? 338 VAL A CG1 1 
ATOM   2163 C  CG2 . VAL A 1 380 ? 11.26049 12.36854  -35.40438  1.000 16.87505  ? 338 VAL A CG2 1 
ATOM   2164 N  N   . SER A 1 381 ? 13.39405 9.34088   -38.47128  1.000 22.35861  ? 339 SER A N   1 
ATOM   2165 C  CA  . SER A 1 381 ? 14.35366 8.90705   -39.49210  1.000 24.01103  ? 339 SER A CA  1 
ATOM   2166 C  C   . SER A 1 381 ? 14.18088 9.62538   -40.81242  1.000 18.97123  ? 339 SER A C   1 
ATOM   2167 O  O   . SER A 1 381 ? 15.14051 9.70203   -41.58389  1.000 19.37884  ? 339 SER A O   1 
ATOM   2168 C  CB  . SER A 1 381 ? 14.23235 7.39424   -39.74331  1.000 27.13875  ? 339 SER A CB  1 
ATOM   2169 O  OG  . SER A 1 381 ? 12.90359 7.11876   -40.10291  1.000 30.72221  ? 339 SER A OG  1 
ATOM   2170 N  N   . SER A 1 382 ? 12.97180 10.12843  -41.09870  1.000 19.95331  ? 340 SER A N   1 
ATOM   2171 C  CA  . SER A 1 382 ? 12.70494 10.81713  -42.35578  1.000 22.78789  ? 340 SER A CA  1 
ATOM   2172 C  C   . SER A 1 382 ? 13.61157 12.03803  -42.51623  1.000 19.29803  ? 340 SER A C   1 
ATOM   2173 O  O   . SER A 1 382 ? 13.56013 12.96930  -41.70845  1.000 21.50146  ? 340 SER A O   1 
ATOM   2174 C  CB  . SER A 1 382 ? 11.23777 11.23903  -42.39882  1.000 26.54678  ? 340 SER A CB  1 
ATOM   2175 O  OG  . SER A 1 382 ? 10.93509 11.82289  -43.65289  1.000 33.24841  ? 340 SER A OG  1 
ATOM   2176 N  N   . ASN A 1 383 ? 14.39235 12.05701  -43.59104  1.000 16.96312  ? 341 ASN A N   1 
ATOM   2177 C  CA  . ASN A 1 383 ? 15.41742 13.07971  -43.81965  1.000 19.60993  ? 341 ASN A CA  1 
ATOM   2178 C  C   . ASN A 1 383 ? 16.38409 13.17968  -42.63511  1.000 26.04034  ? 341 ASN A C   1 
ATOM   2179 O  O   . ASN A 1 383 ? 17.05327 14.19151  -42.48156  1.000 22.37631  ? 341 ASN A O   1 
ATOM   2180 C  CB  . ASN A 1 383 ? 14.80138 14.46915  -44.09866  1.000 24.65508  ? 341 ASN A CB  1 
ATOM   2181 C  CG  . ASN A 1 383 ? 15.26997 15.08251  -45.42618  1.000 25.13261  ? 341 ASN A CG  1 
ATOM   2182 O  OD1 . ASN A 1 383 ? 16.34414 14.74817  -45.97140  1.000 21.44760  ? 341 ASN A OD1 1 
ATOM   2183 N  ND2 . ASN A 1 383 ? 14.48470 16.02724  -45.92708  1.000 22.22691  ? 341 ASN A ND2 1 
ATOM   2184 N  N   . GLY A 1 384 ? 16.50465 12.12574  -41.81035  1.000 20.58817  ? 342 GLY A N   1 
ATOM   2185 C  CA  . GLY A 1 384 ? 17.23906 12.25286  -40.56919  1.000 16.11361  ? 342 GLY A CA  1 
ATOM   2186 C  C   . GLY A 1 384 ? 18.74940 12.21299  -40.71891  1.000 18.04916  ? 342 GLY A C   1 
ATOM   2187 O  O   . GLY A 1 384 ? 19.45781 12.53453  -39.76475  1.000 17.60813  ? 342 GLY A O   1 
ATOM   2188 N  N   . ALA A 1 385 ? 19.25230 11.72677  -41.84764  1.000 12.56357  ? 343 ALA A N   1 
ATOM   2189 C  CA  . ALA A 1 385 ? 20.69147 11.61660  -42.02620  1.000 14.88743  ? 343 ALA A CA  1 
ATOM   2190 C  C   . ALA A 1 385 ? 21.24646 13.01099  -42.29678  1.000 19.31940  ? 343 ALA A C   1 
ATOM   2191 O  O   . ALA A 1 385 ? 20.50304 13.92714  -42.67685  1.000 15.84818  ? 343 ALA A O   1 
ATOM   2192 C  CB  . ALA A 1 385 ? 21.01813 10.66632  -43.18099  1.000 13.90175  ? 343 ALA A CB  1 
ATOM   2193 N  N   . ASN A 1 386 ? 22.56138 13.18364  -42.07627  1.000 16.11896  ? 344 ASN A N   1 
ATOM   2194 C  CA  . ASN A 1 386 ? 23.17070 14.51223  -42.14169  1.000 17.87095  ? 344 ASN A CA  1 
ATOM   2195 C  C   . ASN A 1 386 ? 22.52714 15.39319  -41.07819  1.000 12.23486  ? 344 ASN A C   1 
ATOM   2196 O  O   . ASN A 1 386 ? 21.81184 14.89114  -40.20846  1.000 21.45850  ? 344 ASN A O   1 
ATOM   2197 C  CB  . ASN A 1 386 ? 23.03546 15.11587  -43.53917  1.000 12.79160  ? 344 ASN A CB  1 
ATOM   2198 C  CG  . ASN A 1 386 ? 24.08509 16.15378  -43.82192  1.000 27.95808  ? 344 ASN A CG  1 
ATOM   2199 O  OD1 . ASN A 1 386 ? 24.83718 16.55566  -42.93162  1.000 23.61185  ? 344 ASN A OD1 1 
ATOM   2200 N  ND2 . ASN A 1 386 ? 24.13508 16.60671  -45.05815  1.000 32.13106  ? 344 ASN A ND2 1 
ATOM   2201 N  N   . GLY A 1 387 ? 22.77695 16.69127  -41.09398  1.000 13.89087  ? 345 GLY A N   1 
ATOM   2202 C  CA  . GLY A 1 387 ? 22.34500 17.50178  -39.97789  1.000 18.32219  ? 345 GLY A CA  1 
ATOM   2203 C  C   . GLY A 1 387 ? 23.02363 18.85995  -40.00399  1.000 17.20910  ? 345 GLY A C   1 
ATOM   2204 O  O   . GLY A 1 387 ? 23.68481 19.23275  -40.98462  1.000 14.85508  ? 345 GLY A O   1 
ATOM   2205 N  N   . VAL A 1 388 ? 22.82639 19.59819  -38.91134  1.000 16.60490  ? 346 VAL A N   1 
ATOM   2206 C  CA  . VAL A 1 388 ? 23.48429 20.88638  -38.70741  1.000 18.49704  ? 346 VAL A CA  1 
ATOM   2207 C  C   . VAL A 1 388 ? 23.61866 21.06399  -37.21082  1.000 19.46606  ? 346 VAL A C   1 
ATOM   2208 O  O   . VAL A 1 388 ? 22.72249 20.68203  -36.45240  1.000 18.50497  ? 346 VAL A O   1 
ATOM   2209 C  CB  . VAL A 1 388 ? 22.74285 22.07521  -39.39201  1.000 18.41940  ? 346 VAL A CB  1 
ATOM   2210 C  CG1 . VAL A 1 388 ? 21.35738 22.42068  -38.72984  1.000 17.22718  ? 346 VAL A CG1 1 
ATOM   2211 C  CG2 . VAL A 1 388 ? 23.63053 23.34655  -39.41800  1.000 14.71454  ? 346 VAL A CG2 1 
ATOM   2212 N  N   . LYS A 1 389 ? 24.76077 21.60394  -36.77965  1.000 14.13630  ? 347 LYS A N   1 
ATOM   2213 C  CA  . LYS A 1 389 ? 24.92601 21.94319  -35.36709  1.000 14.53731  ? 347 LYS A CA  1 
ATOM   2214 C  C   . LYS A 1 389 ? 23.82913 22.89786  -34.92493  1.000 15.54972  ? 347 LYS A C   1 
ATOM   2215 O  O   . LYS A 1 389 ? 23.56475 23.90209  -35.59559  1.000 13.25758  ? 347 LYS A O   1 
ATOM   2216 C  CB  . LYS A 1 389 ? 26.29005 22.61972  -35.09787  1.000 13.91256  ? 347 LYS A CB  1 
ATOM   2217 C  CG  . LYS A 1 389 ? 26.38593 23.00529  -33.61030  1.000 16.46757  ? 347 LYS A CG  1 
ATOM   2218 C  CD  . LYS A 1 389 ? 27.72005 23.50125  -33.15149  1.000 19.87666  ? 347 LYS A CD  1 
ATOM   2219 C  CE  . LYS A 1 389 ? 27.62300 23.90614  -31.70571  1.000 21.21733  ? 347 LYS A CE  1 
ATOM   2220 N  NZ  . LYS A 1 389 ? 27.50759 22.79544  -30.68562  1.000 16.24245  ? 347 LYS A NZ  1 
ATOM   2221 N  N   . GLY A 1 390 ? 23.22119 22.60078  -33.78050  1.000 17.15643  ? 348 GLY A N   1 
ATOM   2222 C  CA  . GLY A 1 390 ? 22.16537 23.42205  -33.26001  1.000 15.25360  ? 348 GLY A CA  1 
ATOM   2223 C  C   . GLY A 1 390 ? 22.04438 23.32942  -31.76409  1.000 14.91797  ? 348 GLY A C   1 
ATOM   2224 O  O   . GLY A 1 390 ? 22.92568 22.78347  -31.10073  1.000 13.77791  ? 348 GLY A O   1 
ATOM   2225 N  N   . PHE A 1 391 ? 20.94693 23.85266  -31.22511  1.000 15.11023  ? 349 PHE A N   1 
ATOM   2226 C  CA  . PHE A 1 391 ? 20.78626 23.94506  -29.78400  1.000 15.56169  ? 349 PHE A CA  1 
ATOM   2227 C  C   . PHE A 1 391 ? 19.29548 24.02728  -29.47918  1.000 16.18639  ? 349 PHE A C   1 
ATOM   2228 O  O   . PHE A 1 391 ? 18.46560 24.28131  -30.36088  1.000 16.43905  ? 349 PHE A O   1 
ATOM   2229 C  CB  . PHE A 1 391 ? 21.52856 25.18496  -29.25356  1.000 18.93449  ? 349 PHE A CB  1 
ATOM   2230 C  CG  . PHE A 1 391 ? 20.82518 26.46017  -29.60370  1.000 18.38760  ? 349 PHE A CG  1 
ATOM   2231 C  CD1 . PHE A 1 391 ? 21.03101 27.05491  -30.84154  1.000 12.24116  ? 349 PHE A CD1 1 
ATOM   2232 C  CD2 . PHE A 1 391 ? 19.88409 27.01505  -28.72720  1.000 15.97893  ? 349 PHE A CD2 1 
ATOM   2233 C  CE1 . PHE A 1 391 ? 20.29466 28.22438  -31.19851  1.000 12.46418  ? 349 PHE A CE1 1 
ATOM   2234 C  CE2 . PHE A 1 391 ? 19.16944 28.17133  -29.07035  1.000 19.27070  ? 349 PHE A CE2 1 
ATOM   2235 C  CZ  . PHE A 1 391 ? 19.35910 28.76478  -30.30180  1.000 13.78695  ? 349 PHE A CZ  1 
ATOM   2236 N  N   . SER A 1 392 ? 18.96778 23.85945  -28.20111  1.000 11.83068  ? 350 SER A N   1 
ATOM   2237 C  CA  . SER A 1 392 ? 17.64210 24.17363  -27.70021  1.000 15.85682  ? 350 SER A CA  1 
ATOM   2238 C  C   . SER A 1 392 ? 17.79919 24.36910  -26.20631  1.000 21.19297  ? 350 SER A C   1 
ATOM   2239 O  O   . SER A 1 392 ? 18.75128 23.87408  -25.60316  1.000 14.42733  ? 350 SER A O   1 
ATOM   2240 C  CB  . SER A 1 392 ? 16.61048 23.06759  -27.99596  1.000 17.04791  ? 350 SER A CB  1 
ATOM   2241 O  OG  . SER A 1 392 ? 16.30099 23.00411  -29.38293  1.000 18.65803  ? 350 SER A OG  1 
ATOM   2242 N  N   . PHE A 1 393 ? 16.85923 25.09247  -25.61499  1.000 17.47351  ? 351 PHE A N   1 
ATOM   2243 C  CA  . PHE A 1 393 ? 16.84126 25.30822  -24.17757  1.000 18.50880  ? 351 PHE A CA  1 
ATOM   2244 C  C   . PHE A 1 393 ? 15.58224 24.69222  -23.60254  1.000 22.02807  ? 351 PHE A C   1 
ATOM   2245 O  O   . PHE A 1 393 ? 14.47686 25.04587  -24.02555  1.000 24.41827  ? 351 PHE A O   1 
ATOM   2246 C  CB  . PHE A 1 393 ? 16.88215 26.79922  -23.85429  1.000 15.44836  ? 351 PHE A CB  1 
ATOM   2247 C  CG  . PHE A 1 393 ? 18.22066 27.43418  -24.17812  1.000 16.50361  ? 351 PHE A CG  1 
ATOM   2248 C  CD1 . PHE A 1 393 ? 19.32301 27.12279  -23.43172  1.000 16.37111  ? 351 PHE A CD1 1 
ATOM   2249 C  CD2 . PHE A 1 393 ? 18.34682 28.34554  -25.21964  1.000 21.08208  ? 351 PHE A CD2 1 
ATOM   2250 C  CE1 . PHE A 1 393 ? 20.56413 27.70730  -23.70626  1.000 15.01575  ? 351 PHE A CE1 1 
ATOM   2251 C  CE2 . PHE A 1 393 ? 19.54554 28.93033  -25.51378  1.000 19.74792  ? 351 PHE A CE2 1 
ATOM   2252 C  CZ  . PHE A 1 393 ? 20.67404 28.61173  -24.76712  1.000 16.26251  ? 351 PHE A CZ  1 
ATOM   2253 N  N   . LYS A 1 394 ? 15.74759 23.83250  -22.60074  1.000 23.19388  ? 352 LYS A N   1 
ATOM   2254 C  CA  . LYS A 1 394 ? 14.61821 23.17302  -21.94672  1.000 21.26643  ? 352 LYS A CA  1 
ATOM   2255 C  C   . LYS A 1 394 ? 14.08927 24.02723  -20.79676  1.000 25.56560  ? 352 LYS A C   1 
ATOM   2256 O  O   . LYS A 1 394 ? 14.84558 24.45256  -19.91837  1.000 20.68895  ? 352 LYS A O   1 
ATOM   2257 C  CB  . LYS A 1 394 ? 15.05339 21.79974  -21.44296  1.000 21.70429  ? 352 LYS A CB  1 
ATOM   2258 C  CG  . LYS A 1 394 ? 14.01586 21.03460  -20.64856  1.000 24.18833  ? 352 LYS A CG  1 
ATOM   2259 C  CD  . LYS A 1 394 ? 14.62709 19.72318  -20.16605  1.000 27.57166  ? 352 LYS A CD  1 
ATOM   2260 C  CE  . LYS A 1 394 ? 13.68756 18.90955  -19.30459  1.000 27.73622  ? 352 LYS A CE  1 
ATOM   2261 N  NZ  . LYS A 1 394 ? 13.28488 19.70948  -18.15059  1.000 30.85781  ? 352 LYS A NZ  1 
ATOM   2262 N  N   . TYR A 1 395 ? 12.78380 24.28167  -20.79888  1.000 19.78581  ? 353 TYR A N   1 
ATOM   2263 C  CA  . TYR A 1 395 ? 12.12309 24.96243  -19.68509  1.000 21.63961  ? 353 TYR A CA  1 
ATOM   2264 C  C   . TYR A 1 395 ? 10.96199 24.08029  -19.21062  1.000 25.36280  ? 353 TYR A C   1 
ATOM   2265 O  O   . TYR A 1 395 ? 9.87892  24.12180  -19.80286  1.000 20.17730  ? 353 TYR A O   1 
ATOM   2266 C  CB  . TYR A 1 395 ? 11.60729 26.33161  -20.11518  1.000 18.37715  ? 353 TYR A CB  1 
ATOM   2267 C  CG  . TYR A 1 395 ? 12.65404 27.41753  -20.15607  1.000 21.36181  ? 353 TYR A CG  1 
ATOM   2268 C  CD1 . TYR A 1 395 ? 13.43205 27.62744  -21.28688  1.000 16.16042  ? 353 TYR A CD1 1 
ATOM   2269 C  CD2 . TYR A 1 395 ? 12.82913 28.25522  -19.06931  1.000 22.49206  ? 353 TYR A CD2 1 
ATOM   2270 C  CE1 . TYR A 1 395 ? 14.39096 28.65164  -21.31734  1.000 23.83574  ? 353 TYR A CE1 1 
ATOM   2271 C  CE2 . TYR A 1 395 ? 13.78939 29.26523  -19.08426  1.000 26.25293  ? 353 TYR A CE2 1 
ATOM   2272 C  CZ  . TYR A 1 395 ? 14.56127 29.45736  -20.20605  1.000 20.86784  ? 353 TYR A CZ  1 
ATOM   2273 O  OH  . TYR A 1 395 ? 15.47843 30.48081  -20.19072  1.000 24.29463  ? 353 TYR A OH  1 
ATOM   2274 N  N   . GLY A 1 396 ? 11.16952 23.31001  -18.14019  1.000 22.10099  ? 354 GLY A N   1 
ATOM   2275 C  CA  . GLY A 1 396 ? 10.13706 22.37186  -17.71270  1.000 28.79460  ? 354 GLY A CA  1 
ATOM   2276 C  C   . GLY A 1 396 ? 9.90854  21.33547  -18.79192  1.000 31.74568  ? 354 GLY A C   1 
ATOM   2277 O  O   . GLY A 1 396 ? 10.85055 20.67420  -19.23734  1.000 26.54872  ? 354 GLY A O   1 
ATOM   2278 N  N   . ASN A 1 397 ? 8.65058  21.17875  -19.22401  1.000 21.51248  ? 355 ASN A N   1 
ATOM   2279 C  CA  . ASN A 1 397 ? 8.32360  20.33906  -20.38375  1.000 21.75811  ? 355 ASN A CA  1 
ATOM   2280 C  C   . ASN A 1 397 ? 8.35056  21.09896  -21.69990  1.000 21.38790  ? 355 ASN A C   1 
ATOM   2281 O  O   . ASN A 1 397 ? 8.11346  20.48877  -22.75648  1.000 14.87081  ? 355 ASN A O   1 
ATOM   2282 C  CB  . ASN A 1 397 ? 6.91840  19.70092  -20.25901  1.000 25.50891  ? 355 ASN A CB  1 
ATOM   2283 C  CG  . ASN A 1 397 ? 6.77461  18.76997  -19.06350  1.000 31.77681  ? 355 ASN A CG  1 
ATOM   2284 O  OD1 . ASN A 1 397 ? 7.63849  17.92429  -18.79756  1.000 39.20063  ? 355 ASN A OD1 1 
ATOM   2285 N  ND2 . ASN A 1 397 ? 5.66318  18.91056  -18.34480  1.000 37.08511  ? 355 ASN A ND2 1 
ATOM   2286 N  N   . GLY A 1 398 ? 8.53793  22.43430  -21.66108  1.000 17.31492  ? 356 GLY A N   1 
ATOM   2287 C  CA  . GLY A 1 398 ? 8.60730  23.21759  -22.88257  1.000 17.82159  ? 356 GLY A CA  1 
ATOM   2288 C  C   . GLY A 1 398 ? 10.04089 23.37102  -23.38180  1.000 24.95502  ? 356 GLY A C   1 
ATOM   2289 O  O   . GLY A 1 398 ? 11.00712 23.01882  -22.71258  1.000 21.43835  ? 356 GLY A O   1 
ATOM   2290 N  N   . VAL A 1 399 ? 10.17928 23.90761  -24.58711  1.000 22.25985  ? 357 VAL A N   1 
ATOM   2291 C  CA  . VAL A 1 399 ? 11.50174 24.01257  -25.18921  1.000 22.26427  ? 357 VAL A CA  1 
ATOM   2292 C  C   . VAL A 1 399 ? 11.52893 25.25025  -26.07184  1.000 20.75214  ? 357 VAL A C   1 
ATOM   2293 O  O   . VAL A 1 399 ? 10.57302 25.51943  -26.80290  1.000 18.30215  ? 357 VAL A O   1 
ATOM   2294 C  CB  . VAL A 1 399 ? 11.85586 22.72860  -25.98077  1.000 19.14842  ? 357 VAL A CB  1 
ATOM   2295 C  CG1 . VAL A 1 399 ? 10.79896 22.44677  -27.01374  1.000 17.23998  ? 357 VAL A CG1 1 
ATOM   2296 C  CG2 . VAL A 1 399 ? 13.22559 22.86250  -26.67311  1.000 16.58678  ? 357 VAL A CG2 1 
ATOM   2297 N  N   . TRP A 1 400 ? 12.63187 26.00997  -25.99263  1.000 14.83815  ? 358 TRP A N   1 
ATOM   2298 C  CA  . TRP A 1 400 ? 12.96253 26.99721  -27.00736  1.000 19.03020  ? 358 TRP A CA  1 
ATOM   2299 C  C   . TRP A 1 400 ? 13.84176 26.32897  -28.05969  1.000 17.83325  ? 358 TRP A C   1 
ATOM   2300 O  O   . TRP A 1 400 ? 14.97807 25.92990  -27.76463  1.000 18.93658  ? 358 TRP A O   1 
ATOM   2301 C  CB  . TRP A 1 400 ? 13.69588 28.19549  -26.39080  1.000 16.73916  ? 358 TRP A CB  1 
ATOM   2302 C  CG  . TRP A 1 400 ? 12.83290 29.31850  -25.84169  1.000 16.08549  ? 358 TRP A CG  1 
ATOM   2303 C  CD1 . TRP A 1 400 ? 12.61669 29.63887  -24.52186  1.000 16.90874  ? 358 TRP A CD1 1 
ATOM   2304 C  CD2 . TRP A 1 400 ? 12.14334 30.30544  -26.60730  1.000 14.94164  ? 358 TRP A CD2 1 
ATOM   2305 N  NE1 . TRP A 1 400 ? 11.80792 30.75839  -24.42585  1.000 15.16781  ? 358 TRP A NE1 1 
ATOM   2306 C  CE2 . TRP A 1 400 ? 11.52667 31.20019  -25.69433  1.000 17.03795  ? 358 TRP A CE2 1 
ATOM   2307 C  CE3 . TRP A 1 400 ? 12.01038 30.54200  -27.97578  1.000 18.41096  ? 358 TRP A CE3 1 
ATOM   2308 C  CZ2 . TRP A 1 400 ? 10.76818 32.29561  -26.11423  1.000 14.13363  ? 358 TRP A CZ2 1 
ATOM   2309 C  CZ3 . TRP A 1 400 ? 11.22971 31.63409  -28.38873  1.000 17.26138  ? 358 TRP A CZ3 1 
ATOM   2310 C  CH2 . TRP A 1 400 ? 10.63813 32.49546  -27.45576  1.000 17.13013  ? 358 TRP A CH2 1 
ATOM   2311 N  N   . ILE A 1 401 ? 13.33274 26.23861  -29.28880  1.000 20.28698  ? 359 ILE A N   1 
ATOM   2312 C  CA  . ILE A 1 401 ? 14.01767 25.60477  -30.41454  1.000 13.72660  ? 359 ILE A CA  1 
ATOM   2313 C  C   . ILE A 1 401 ? 14.52760 26.72362  -31.31363  1.000 24.91739  ? 359 ILE A C   1 
ATOM   2314 O  O   . ILE A 1 401 ? 13.74867 27.60688  -31.69389  1.000 19.98355  ? 359 ILE A O   1 
ATOM   2315 C  CB  . ILE A 1 401 ? 13.06291 24.69962  -31.20758  1.000 18.95022  ? 359 ILE A CB  1 
ATOM   2316 C  CG1 . ILE A 1 401 ? 12.60806 23.51886  -30.36400  1.000 22.52994  ? 359 ILE A CG1 1 
ATOM   2317 C  CG2 . ILE A 1 401 ? 13.68684 24.23222  -32.51735  1.000 16.40303  ? 359 ILE A CG2 1 
ATOM   2318 C  CD1 . ILE A 1 401 ? 11.40345 22.83054  -30.95202  1.000 23.12807  ? 359 ILE A CD1 1 
ATOM   2319 N  N   . GLY A 1 402 ? 15.82378 26.72454  -31.63031  1.000 17.07843  ? 360 GLY A N   1 
ATOM   2320 C  CA  . GLY A 1 402 ? 16.33381 27.55412  -32.71032  1.000 11.89176  ? 360 GLY A CA  1 
ATOM   2321 C  C   . GLY A 1 402 ? 16.56691 26.64715  -33.90526  1.000 13.07562  ? 360 GLY A C   1 
ATOM   2322 O  O   . GLY A 1 402 ? 17.11922 25.57058  -33.75562  1.000 14.21303  ? 360 GLY A O   1 
ATOM   2323 N  N   . ARG A 1 403 ? 16.14028 27.08639  -35.09110  1.000 13.73271  ? 361 ARG A N   1 
ATOM   2324 C  CA  . ARG A 1 403 ? 16.30076 26.19236  -36.22974  1.000 16.58997  ? 361 ARG A CA  1 
ATOM   2325 C  C   . ARG A 1 403 ? 16.33192 26.99157  -37.51944  1.000 14.14511  ? 361 ARG A C   1 
ATOM   2326 O  O   . ARG A 1 403 ? 15.89131 28.14103  -37.55950  1.000 20.64529  ? 361 ARG A O   1 
ATOM   2327 C  CB  . ARG A 1 403 ? 15.16269 25.14525  -36.28561  1.000 18.52447  ? 361 ARG A CB  1 
ATOM   2328 C  CG  . ARG A 1 403 ? 13.75355 25.72692  -36.52604  1.000 20.77409  ? 361 ARG A CG  1 
ATOM   2329 C  CD  . ARG A 1 403 ? 12.72872 24.56709  -36.63632  1.000 18.93881  ? 361 ARG A CD  1 
ATOM   2330 N  NE  . ARG A 1 403 ? 11.47151 25.05206  -37.21180  1.000 21.34122  ? 361 ARG A NE  1 
ATOM   2331 C  CZ  . ARG A 1 403 ? 10.43239 24.27858  -37.51528  1.000 27.09151  ? 361 ARG A CZ  1 
ATOM   2332 N  NH1 . ARG A 1 403 ? 10.46255 22.96264  -37.32769  1.000 17.44729  ? 361 ARG A NH1 1 
ATOM   2333 N  NH2 . ARG A 1 403 ? 9.32855  24.83812  -37.99326  1.000 18.11418  ? 361 ARG A NH2 1 
ATOM   2334 N  N   . THR A 1 404 ? 16.83291 26.36467  -38.59006  1.000 16.48190  ? 362 THR A N   1 
ATOM   2335 C  CA  . THR A 1 404 ? 16.71071 26.99699  -39.89705  1.000 14.32830  ? 362 THR A CA  1 
ATOM   2336 C  C   . THR A 1 404 ? 15.22812 27.15622  -40.24175  1.000 21.07651  ? 362 THR A C   1 
ATOM   2337 O  O   . THR A 1 404 ? 14.35804 26.50965  -39.64746  1.000 17.32008  ? 362 THR A O   1 
ATOM   2338 C  CB  . THR A 1 404 ? 17.41236 26.17658  -40.98096  1.000 17.26409  ? 362 THR A CB  1 
ATOM   2339 O  OG1 . THR A 1 404 ? 16.71030 24.93960  -41.17838  1.000 20.65453  ? 362 THR A OG1 1 
ATOM   2340 C  CG2 . THR A 1 404 ? 18.93192 25.91523  -40.63009  1.000 9.11427   ? 362 THR A CG2 1 
ATOM   2341 N  N   . LYS A 1 405 ? 14.93711 28.04217  -41.19850  1.000 16.65223  ? 363 LYS A N   1 
ATOM   2342 C  CA  . LYS A 1 405 ? 13.57105 28.12638  -41.70577  1.000 21.67299  ? 363 LYS A CA  1 
ATOM   2343 C  C   . LYS A 1 405 ? 13.32189 27.13591  -42.82736  1.000 20.51137  ? 363 LYS A C   1 
ATOM   2344 O  O   . LYS A 1 405 ? 12.20519 26.63649  -42.95105  1.000 18.94387  ? 363 LYS A O   1 
ATOM   2345 C  CB  . LYS A 1 405 ? 13.23092 29.55967  -42.17511  1.000 12.33534  ? 363 LYS A CB  1 
ATOM   2346 C  CG  . LYS A 1 405 ? 12.98830 30.51785  -41.03188  1.000 15.68717  ? 363 LYS A CG  1 
ATOM   2347 C  CD  . LYS A 1 405 ? 12.68622 31.95660  -41.47282  1.000 18.73711  ? 363 LYS A CD  1 
ATOM   2348 C  CE  . LYS A 1 405 ? 12.22738 32.80857  -40.28872  1.000 16.22091  ? 363 LYS A CE  1 
ATOM   2349 N  NZ  . LYS A 1 405 ? 10.87425 32.43699  -39.72218  1.000 21.60237  ? 363 LYS A NZ  1 
ATOM   2350 N  N   . SER A 1 406 ? 14.33683 26.83535  -43.63118  1.000 18.10816  ? 364 SER A N   1 
ATOM   2351 C  CA  . SER A 1 406 ? 14.22874 25.86608  -44.71177  1.000 25.30194  ? 364 SER A CA  1 
ATOM   2352 C  C   . SER A 1 406 ? 14.32982 24.45988  -44.14016  1.000 19.16081  ? 364 SER A C   1 
ATOM   2353 O  O   . SER A 1 406 ? 15.09722 24.23510  -43.19810  1.000 17.59298  ? 364 SER A O   1 
ATOM   2354 C  CB  . SER A 1 406 ? 15.34854 26.11919  -45.72491  1.000 22.50748  ? 364 SER A CB  1 
ATOM   2355 O  OG  . SER A 1 406 ? 15.48308 25.05304  -46.65853  1.000 25.92742  ? 364 SER A OG  1 
ATOM   2356 N  N   . ILE A 1 407 ? 13.53432 23.52038  -44.68067  1.000 18.80881  ? 365 ILE A N   1 
ATOM   2357 C  CA  . ILE A 1 407 ? 13.64422 22.13138  -44.21991  1.000 21.73689  ? 365 ILE A CA  1 
ATOM   2358 C  C   . ILE A 1 407 ? 14.76003 21.36910  -44.91616  1.000 23.37319  ? 365 ILE A C   1 
ATOM   2359 O  O   . ILE A 1 407 ? 15.10431 20.26890  -44.49075  1.000 23.99621  ? 365 ILE A O   1 
ATOM   2360 C  CB  . ILE A 1 407 ? 12.36980 21.28761  -44.41332  1.000 20.13028  ? 365 ILE A CB  1 
ATOM   2361 C  CG1 . ILE A 1 407 ? 11.98438 21.19389  -45.88460  1.000 22.53306  ? 365 ILE A CG1 1 
ATOM   2362 C  CG2 . ILE A 1 407 ? 11.22416 21.83912  -43.59500  1.000 16.11623  ? 365 ILE A CG2 1 
ATOM   2363 C  CD1 . ILE A 1 407 ? 10.75527 20.28725  -46.12333  1.000 24.24229  ? 365 ILE A CD1 1 
ATOM   2364 N  N   . SER A 1 408 ? 15.30706 21.91351  -45.99165  1.000 17.60966  ? 366 SER A N   1 
ATOM   2365 C  CA  . SER A 1 408 ? 16.20966 21.20033  -46.86627  1.000 26.04345  ? 366 SER A CA  1 
ATOM   2366 C  C   . SER A 1 408 ? 17.60129 21.82662  -46.99262  1.000 24.00197  ? 366 SER A C   1 
ATOM   2367 O  O   . SER A 1 408 ? 18.50923 21.13633  -47.43974  1.000 19.89096  ? 366 SER A O   1 
ATOM   2368 C  CB  . SER A 1 408 ? 15.57866 21.06917  -48.26287  1.000 25.13816  ? 366 SER A CB  1 
ATOM   2369 O  OG  . SER A 1 408 ? 15.31874 22.36130  -48.79187  1.000 27.19633  ? 366 SER A OG  1 
ATOM   2370 N  N   . SER A 1 409 ? 17.78521 23.10971  -46.69761  1.000 20.47426  ? 367 SER A N   1 
ATOM   2371 C  CA  . SER A 1 409 ? 19.12129 23.69067  -46.75372  1.000 29.43778  ? 367 SER A CA  1 
ATOM   2372 C  C   . SER A 1 409 ? 19.27603 24.72247  -45.64318  1.000 19.62382  ? 367 SER A C   1 
ATOM   2373 O  O   . SER A 1 409 ? 18.32293 25.07836  -44.95313  1.000 24.64128  ? 367 SER A O   1 
ATOM   2374 C  CB  . SER A 1 409 ? 19.41740 24.29795  -48.12180  1.000 17.98697  ? 367 SER A CB  1 
ATOM   2375 O  OG  . SER A 1 409 ? 18.43751 25.24444  -48.40803  1.000 29.45061  ? 367 SER A OG  1 
ATOM   2376 N  N   . ARG A 1 410 ? 20.49944 25.19948  -45.47065  1.000 19.74244  ? 368 ARG A N   1 
ATOM   2377 C  CA  . ARG A 1 410 ? 20.83107 26.02612  -44.31330  1.000 19.81022  ? 368 ARG A CA  1 
ATOM   2378 C  C   . ARG A 1 410 ? 20.48354 27.47832  -44.64000  1.000 17.94676  ? 368 ARG A C   1 
ATOM   2379 O  O   . ARG A 1 410 ? 21.34880 28.32458  -44.94271  1.000 18.33967  ? 368 ARG A O   1 
ATOM   2380 C  CB  . ARG A 1 410 ? 22.29259 25.83671  -43.94262  1.000 17.07706  ? 368 ARG A CB  1 
ATOM   2381 C  CG  . ARG A 1 410 ? 22.60356 24.39201  -43.47876  1.000 18.66597  ? 368 ARG A CG  1 
ATOM   2382 C  CD  . ARG A 1 410 ? 24.08343 24.14608  -43.39446  1.000 15.48605  ? 368 ARG A CD  1 
ATOM   2383 N  NE  . ARG A 1 410 ? 24.31062 22.81700  -42.84009  1.000 23.68636  ? 368 ARG A NE  1 
ATOM   2384 C  CZ  . ARG A 1 410 ? 25.50348 22.31709  -42.56111  1.000 24.65239  ? 368 ARG A CZ  1 
ATOM   2385 N  NH1 . ARG A 1 410 ? 26.61515 22.99948  -42.80665  1.000 19.06974  ? 368 ARG A NH1 1 
ATOM   2386 N  NH2 . ARG A 1 410 ? 25.58077 21.12893  -41.97400  1.000 18.59521  ? 368 ARG A NH2 1 
ATOM   2387 N  N   . ASN A 1 411 ? 19.16614 27.74040  -44.61384  1.000 17.74077  ? 369 ASN A N   1 
ATOM   2388 C  CA  . ASN A 1 411 ? 18.60291 29.05703  -44.91808  1.000 18.17112  ? 369 ASN A CA  1 
ATOM   2389 C  C   . ASN A 1 411 ? 17.59852 29.48957  -43.86251  1.000 18.96745  ? 369 ASN A C   1 
ATOM   2390 O  O   . ASN A 1 411 ? 16.75639 28.70483  -43.42244  1.000 14.42669  ? 369 ASN A O   1 
ATOM   2391 C  CB  . ASN A 1 411 ? 17.95217 29.06163  -46.29199  1.000 21.71560  ? 369 ASN A CB  1 
ATOM   2392 C  CG  . ASN A 1 411 ? 18.97217 28.88835  -47.36795  1.000 33.49709  ? 369 ASN A CG  1 
ATOM   2393 O  OD1 . ASN A 1 411 ? 19.20435 27.77342  -47.82229  1.000 37.24714  ? 369 ASN A OD1 1 
ATOM   2394 N  ND2 . ASN A 1 411 ? 19.68261 29.97621  -47.71083  1.000 32.20412  ? 369 ASN A ND2 1 
ATOM   2395 N  N   . GLY A 1 412 ? 17.69097 30.76480  -43.48485  1.000 19.02945  ? 370 GLY A N   1 
ATOM   2396 C  CA  . GLY A 1 412 ? 16.81984 31.33595  -42.49274  1.000 19.62246  ? 370 GLY A CA  1 
ATOM   2397 C  C   . GLY A 1 412 ? 17.16864 30.89003  -41.09514  1.000 16.19955  ? 370 GLY A C   1 
ATOM   2398 O  O   . GLY A 1 412 ? 17.93355 29.94113  -40.90155  1.000 23.24363  ? 370 GLY A O   1 
ATOM   2399 N  N   . PHE A 1 413 ? 16.57973 31.54983  -40.10579  1.000 16.37599  ? 371 PHE A N   1 
ATOM   2400 C  CA  . PHE A 1 413 ? 16.69247 31.07517  -38.74200  1.000 16.99890  ? 371 PHE A CA  1 
ATOM   2401 C  C   . PHE A 1 413 ? 15.55230 31.67069  -37.95376  1.000 18.46332  ? 371 PHE A C   1 
ATOM   2402 O  O   . PHE A 1 413 ? 15.16346 32.82433  -38.19172  1.000 16.87510  ? 371 PHE A O   1 
ATOM   2403 C  CB  . PHE A 1 413 ? 18.02358 31.46013  -38.10308  1.000 12.82033  ? 371 PHE A CB  1 
ATOM   2404 C  CG  . PHE A 1 413 ? 18.42766 30.55829  -36.98595  1.000 17.30130  ? 371 PHE A CG  1 
ATOM   2405 C  CD1 . PHE A 1 413 ? 19.02002 29.32537  -37.26250  1.000 15.22356  ? 371 PHE A CD1 1 
ATOM   2406 C  CD2 . PHE A 1 413 ? 18.26645 30.94707  -35.66159  1.000 13.64669  ? 371 PHE A CD2 1 
ATOM   2407 C  CE1 . PHE A 1 413 ? 19.40823 28.46701  -36.24299  1.000 14.75475  ? 371 PHE A CE1 1 
ATOM   2408 C  CE2 . PHE A 1 413 ? 18.69814 30.08464  -34.62419  1.000 13.06810  ? 371 PHE A CE2 1 
ATOM   2409 C  CZ  . PHE A 1 413 ? 19.26814 28.84698  -34.93661  1.000 13.60010  ? 371 PHE A CZ  1 
ATOM   2410 N  N   . GLU A 1 414 ? 15.04410 30.89118  -37.00052  1.000 17.22864  ? 372 GLU A N   1 
ATOM   2411 C  CA  . GLU A 1 414 ? 13.92806 31.31380  -36.17353  1.000 17.53480  ? 372 GLU A CA  1 
ATOM   2412 C  C   . GLU A 1 414 ? 14.03866 30.68585  -34.78696  1.000 18.70391  ? 372 GLU A C   1 
ATOM   2413 O  O   . GLU A 1 414 ? 14.58235 29.58059  -34.62642  1.000 18.91678  ? 372 GLU A O   1 
ATOM   2414 C  CB  . GLU A 1 414 ? 12.60178 30.93356  -36.84046  1.000 19.47274  ? 372 GLU A CB  1 
ATOM   2415 C  CG  . GLU A 1 414 ? 12.45371 29.39747  -37.08175  1.000 17.71656  ? 372 GLU A CG  1 
ATOM   2416 C  CD  . GLU A 1 414 ? 11.25955 29.03006  -37.99511  1.000 27.99737  ? 372 GLU A CD  1 
ATOM   2417 O  OE1 . GLU A 1 414 ? 10.92239 27.81894  -38.09980  1.000 18.06705  ? 372 GLU A OE1 1 
ATOM   2418 O  OE2 . GLU A 1 414 ? 10.66022 29.96127  -38.60531  1.000 19.67977  ? 372 GLU A OE2 1 
ATOM   2419 N  N   . MET A 1 415 ? 13.50100 31.39706  -33.78158  1.000 18.64843  ? 373 MET A N   1 
ATOM   2420 C  CA  . MET A 1 415 ? 13.35399 30.86980  -32.42838  1.000 12.39948  ? 373 MET A CA  1 
ATOM   2421 C  C   . MET A 1 415 ? 11.88829 30.51959  -32.21034  1.000 22.02212  ? 373 MET A C   1 
ATOM   2422 O  O   . MET A 1 415 ? 11.02226 31.31012  -32.56709  1.000 19.52179  ? 373 MET A O   1 
ATOM   2423 C  CB  . MET A 1 415 ? 13.82165 31.87167  -31.35704  1.000 14.72644  ? 373 MET A CB  1 
ATOM   2424 C  CG  . MET A 1 415 ? 15.34162 32.18275  -31.40857  1.000 11.51117  ? 373 MET A CG  1 
ATOM   2425 S  SD  . MET A 1 415 ? 16.33071 30.65468  -31.19803  1.000 18.18471  ? 373 MET A SD  1 
ATOM   2426 C  CE  . MET A 1 415 ? 15.94846 30.18703  -29.52615  1.000 13.53706  ? 373 MET A CE  1 
ATOM   2427 N  N   . ILE A 1 416 ? 11.61278 29.33567  -31.65075  1.000 17.09588  ? 374 ILE A N   1 
ATOM   2428 C  CA  . ILE A 1 416 ? 10.24088 28.86399  -31.44364  1.000 19.54979  ? 374 ILE A CA  1 
ATOM   2429 C  C   . ILE A 1 416 ? 10.08359 28.41403  -29.99143  1.000 18.54694  ? 374 ILE A C   1 
ATOM   2430 O  O   . ILE A 1 416 ? 10.84880 27.56934  -29.50499  1.000 17.97959  ? 374 ILE A O   1 
ATOM   2431 C  CB  . ILE A 1 416 ? 9.88207  27.73030  -32.41638  1.000 25.53457  ? 374 ILE A CB  1 
ATOM   2432 C  CG1 . ILE A 1 416 ? 9.83057  28.30076  -33.82606  1.000 21.97191  ? 374 ILE A CG1 1 
ATOM   2433 C  CG2 . ILE A 1 416 ? 8.50038  27.06621  -32.05401  1.000 18.48942  ? 374 ILE A CG2 1 
ATOM   2434 C  CD1 . ILE A 1 416 ? 9.65257  27.27616  -34.88766  1.000 23.50900  ? 374 ILE A CD1 1 
ATOM   2435 N  N   . TRP A 1 417 ? 9.12234  28.99894  -29.29387  1.000 17.80914  ? 375 TRP A N   1 
ATOM   2436 C  CA  . TRP A 1 417 ? 8.78137  28.57599  -27.94658  1.000 16.70328  ? 375 TRP A CA  1 
ATOM   2437 C  C   . TRP A 1 417 ? 7.62995  27.58138  -28.05700  1.000 25.46974  ? 375 TRP A C   1 
ATOM   2438 O  O   . TRP A 1 417 ? 6.50682  27.95248  -28.43575  1.000 16.72922  ? 375 TRP A O   1 
ATOM   2439 C  CB  . TRP A 1 417 ? 8.37939  29.76029  -27.07285  1.000 18.12444  ? 375 TRP A CB  1 
ATOM   2440 C  CG  . TRP A 1 417 ? 7.71238  29.30799  -25.77791  1.000 22.52575  ? 375 TRP A CG  1 
ATOM   2441 C  CD1 . TRP A 1 417 ? 6.42276  29.56117  -25.37830  1.000 25.86135  ? 375 TRP A CD1 1 
ATOM   2442 C  CD2 . TRP A 1 417 ? 8.29894  28.51017  -24.74496  1.000 20.06388  ? 375 TRP A CD2 1 
ATOM   2443 N  NE1 . TRP A 1 417 ? 6.19063  29.00080  -24.14264  1.000 20.72936  ? 375 TRP A NE1 1 
ATOM   2444 C  CE2 . TRP A 1 417 ? 7.32053  28.33869  -23.73896  1.000 22.58855  ? 375 TRP A CE2 1 
ATOM   2445 C  CE3 . TRP A 1 417 ? 9.56019  27.91457  -24.57340  1.000 19.35552  ? 375 TRP A CE3 1 
ATOM   2446 C  CZ2 . TRP A 1 417 ? 7.55957  27.58876  -22.57800  1.000 22.52095  ? 375 TRP A CZ2 1 
ATOM   2447 C  CZ3 . TRP A 1 417 ? 9.80961  27.20510  -23.40385  1.000 16.92962  ? 375 TRP A CZ3 1 
ATOM   2448 C  CH2 . TRP A 1 417 ? 8.81072  27.04209  -22.42469  1.000 21.27769  ? 375 TRP A CH2 1 
ATOM   2449 N  N   . ASP A 1 418 ? 7.91479  26.32603  -27.72743  1.000 20.93329  ? 376 ASP A N   1 
ATOM   2450 C  CA  . ASP A 1 418 ? 6.93163  25.24362  -27.77215  1.000 21.00694  ? 376 ASP A CA  1 
ATOM   2451 C  C   . ASP A 1 418 ? 6.69308  24.80465  -26.33994  1.000 19.70299  ? 376 ASP A C   1 
ATOM   2452 O  O   . ASP A 1 418 ? 7.49975  24.03573  -25.78668  1.000 19.99341  ? 376 ASP A O   1 
ATOM   2453 C  CB  . ASP A 1 418 ? 7.44298  24.07647  -28.62766  1.000 14.84265  ? 376 ASP A CB  1 
ATOM   2454 C  CG  . ASP A 1 418 ? 6.40659  22.96313  -28.77813  1.000 30.23837  ? 376 ASP A CG  1 
ATOM   2455 O  OD1 . ASP A 1 418 ? 5.44153  22.96896  -27.97953  1.000 21.71275  ? 376 ASP A OD1 1 
ATOM   2456 O  OD2 . ASP A 1 418 ? 6.56562  22.08721  -29.66977  1.000 22.27957  ? 376 ASP A OD2 1 
ATOM   2457 N  N   . PRO A 1 419 ? 5.59933  25.23785  -25.70194  1.000 20.73727  ? 377 PRO A N   1 
ATOM   2458 C  CA  . PRO A 1 419 ? 5.48215  25.07357  -24.24060  1.000 22.11591  ? 377 PRO A CA  1 
ATOM   2459 C  C   . PRO A 1 419 ? 5.34268  23.62751  -23.76423  1.000 20.80298  ? 377 PRO A C   1 
ATOM   2460 O  O   . PRO A 1 419 ? 5.47681  23.37729  -22.55645  1.000 19.25875  ? 377 PRO A O   1 
ATOM   2461 C  CB  . PRO A 1 419 ? 4.24101  25.91240  -23.89340  1.000 17.29331  ? 377 PRO A CB  1 
ATOM   2462 C  CG  . PRO A 1 419 ? 3.50981  26.06225  -25.17255  1.000 22.60490  ? 377 PRO A CG  1 
ATOM   2463 C  CD  . PRO A 1 419 ? 4.48321  26.02566  -26.26953  1.000 23.48996  ? 377 PRO A CD  1 
ATOM   2464 N  N   . ASN A 1 420 ? 5.12402  22.65809  -24.64730  1.000 17.68757  ? 378 ASN A N   1 
ATOM   2465 C  CA  . ASN A 1 420 ? 5.14508  21.26221  -24.20541  1.000 21.45928  ? 378 ASN A CA  1 
ATOM   2466 C  C   . ASN A 1 420 ? 6.08630  20.42235  -25.06877  1.000 23.52921  ? 378 ASN A C   1 
ATOM   2467 O  O   . ASN A 1 420 ? 5.95408  19.19624  -25.11112  1.000 19.32928  ? 378 ASN A O   1 
ATOM   2468 C  CB  . ASN A 1 420 ? 3.72512  20.66491  -24.22673  1.000 15.78379  ? 378 ASN A CB  1 
ATOM   2469 C  CG  . ASN A 1 420 ? 3.20693  20.47767  -25.64037  1.000 25.41058  ? 378 ASN A CG  1 
ATOM   2470 O  OD1 . ASN A 1 420 ? 3.80956  20.99572  -26.60057  1.000 21.34392  ? 378 ASN A OD1 1 
ATOM   2471 N  ND2 . ASN A 1 420 ? 2.08651  19.72992  -25.79495  1.000 21.97575  ? 378 ASN A ND2 1 
ATOM   2472 N  N   . GLY A 1 421 ? 7.00327  21.06618  -25.79823  1.000 17.72122  ? 379 GLY A N   1 
ATOM   2473 C  CA  . GLY A 1 421 ? 7.71295  20.39890  -26.87327  1.000 16.94931  ? 379 GLY A CA  1 
ATOM   2474 C  C   . GLY A 1 421 ? 8.84797  19.50536  -26.43360  1.000 20.82967  ? 379 GLY A C   1 
ATOM   2475 O  O   . GLY A 1 421 ? 9.34221  18.70464  -27.23835  1.000 21.72803  ? 379 GLY A O   1 
ATOM   2476 N  N   . TRP A 1 422 ? 9.29566  19.63213  -25.19049  1.000 18.45538  ? 380 TRP A N   1 
ATOM   2477 C  CA  . TRP A 1 422 ? 10.34026 18.72664  -24.73919  1.000 21.66287  ? 380 TRP A CA  1 
ATOM   2478 C  C   . TRP A 1 422 ? 9.82803  17.29255  -24.65365  1.000 21.83978  ? 380 TRP A C   1 
ATOM   2479 O  O   . TRP A 1 422 ? 10.52948 16.35238  -25.03314  1.000 18.94383  ? 380 TRP A O   1 
ATOM   2480 C  CB  . TRP A 1 422 ? 10.90665 19.16922  -23.39408  1.000 14.45291  ? 380 TRP A CB  1 
ATOM   2481 C  CG  . TRP A 1 422 ? 12.23702 18.49255  -23.10869  1.000 20.34928  ? 380 TRP A CG  1 
ATOM   2482 C  CD1 . TRP A 1 422 ? 12.44219 17.35868  -22.37251  1.000 21.78008  ? 380 TRP A CD1 1 
ATOM   2483 C  CD2 . TRP A 1 422 ? 13.53206 18.89334  -23.59730  1.000 24.87586  ? 380 TRP A CD2 1 
ATOM   2484 N  NE1 . TRP A 1 422 ? 13.78491 17.05070  -22.34892  1.000 24.85815  ? 380 TRP A NE1 1 
ATOM   2485 C  CE2 . TRP A 1 422 ? 14.47462 17.96679  -23.09726  1.000 22.16512  ? 380 TRP A CE2 1 
ATOM   2486 C  CE3 . TRP A 1 422 ? 13.98122 19.94550  -24.39911  1.000 18.47178  ? 380 TRP A CE3 1 
ATOM   2487 C  CZ2 . TRP A 1 422 ? 15.85230 18.06394  -23.36900  1.000 28.42804  ? 380 TRP A CZ2 1 
ATOM   2488 C  CZ3 . TRP A 1 422 ? 15.35758 20.05127  -24.67617  1.000 23.18885  ? 380 TRP A CZ3 1 
ATOM   2489 C  CH2 . TRP A 1 422 ? 16.27582 19.11410  -24.15370  1.000 24.99834  ? 380 TRP A CH2 1 
ATOM   2490 N  N   . THR A 1 423 ? 8.60182  17.10947  -24.18537  1.000 24.68050  ? 381 THR A N   1 
ATOM   2491 C  CA  . THR A 1 423 ? 8.07711  15.78547  -23.90769  1.000 25.51861  ? 381 THR A CA  1 
ATOM   2492 C  C   . THR A 1 423 ? 6.89877  15.37689  -24.78480  1.000 26.46939  ? 381 THR A C   1 
ATOM   2493 O  O   . THR A 1 423 ? 6.57505  14.19479  -24.80940  1.000 22.14011  ? 381 THR A O   1 
ATOM   2494 C  CB  . THR A 1 423 ? 7.67696  15.71720  -22.43152  1.000 27.92453  ? 381 THR A CB  1 
ATOM   2495 O  OG1 . THR A 1 423 ? 6.77387  16.80315  -22.14448  1.000 28.78102  ? 381 THR A OG1 1 
ATOM   2496 C  CG2 . THR A 1 423 ? 8.92379  15.87065  -21.55420  1.000 25.49082  ? 381 THR A CG2 1 
ATOM   2497 N  N   . GLU A 1 424 ? 6.27939  16.29595  -25.53787  1.000 21.79040  ? 382 GLU A N   1 
ATOM   2498 C  CA  . GLU A 1 424 ? 5.06928  16.00337  -26.30741  1.000 20.55959  ? 382 GLU A CA  1 
ATOM   2499 C  C   . GLU A 1 424 ? 5.33783  16.08868  -27.81180  1.000 27.35158  ? 382 GLU A C   1 
ATOM   2500 O  O   . GLU A 1 424 ? 6.25596  16.77436  -28.26706  1.000 22.55416  ? 382 GLU A O   1 
ATOM   2501 C  CB  . GLU A 1 424 ? 3.95098  16.96407  -25.91785  1.000 27.47990  ? 382 GLU A CB  1 
ATOM   2502 C  CG  . GLU A 1 424 ? 3.57117  16.95047  -24.44229  1.000 25.60523  ? 382 GLU A CG  1 
ATOM   2503 C  CD  . GLU A 1 424 ? 3.32695  15.55892  -23.90444  1.000 40.07624  ? 382 GLU A CD  1 
ATOM   2504 O  OE1 . GLU A 1 424 ? 2.62774  14.75321  -24.56562  1.000 40.75386  ? 382 GLU A OE1 1 
ATOM   2505 O  OE2 . GLU A 1 424 ? 3.80939  15.28509  -22.78765  1.000 54.34182  ? 382 GLU A OE2 1 
ATOM   2506 N  N   . THR A 1 425 ? 4.51765  15.39464  -28.59786  1.000 19.14663  ? 383 THR A N   1 
ATOM   2507 C  CA  . THR A 1 425 ? 4.83739  15.13701  -30.00020  1.000 19.46591  ? 383 THR A CA  1 
ATOM   2508 C  C   . THR A 1 425 ? 4.05571  15.98024  -30.98714  1.000 19.79181  ? 383 THR A C   1 
ATOM   2509 O  O   . THR A 1 425 ? 4.24810  15.83103  -32.20286  1.000 20.73260  ? 383 THR A O   1 
ATOM   2510 C  CB  . THR A 1 425 ? 4.58640  13.65274  -30.33219  1.000 24.92632  ? 383 THR A CB  1 
ATOM   2511 O  OG1 . THR A 1 425 ? 3.25963  13.29702  -29.89872  1.000 21.20415  ? 383 THR A OG1 1 
ATOM   2512 C  CG2 . THR A 1 425 ? 5.61545  12.76863  -29.65385  1.000 22.24397  ? 383 THR A CG2 1 
ATOM   2513 N  N   . ASP A 1 426 ? 3.14752  16.81400  -30.51222  1.000 17.69672  ? 384 ASP A N   1 
ATOM   2514 C  CA  . ASP A 1 426 ? 2.40868  17.65059  -31.43297  1.000 23.35194  ? 384 ASP A CA  1 
ATOM   2515 C  C   . ASP A 1 426 ? 3.35087  18.66791  -32.06574  1.000 27.63421  ? 384 ASP A C   1 
ATOM   2516 O  O   . ASP A 1 426 ? 4.46034  18.92878  -31.56533  1.000 19.07975  ? 384 ASP A O   1 
ATOM   2517 C  CB  . ASP A 1 426 ? 1.26198  18.36655  -30.70393  1.000 21.39506  ? 384 ASP A CB  1 
ATOM   2518 C  CG  . ASP A 1 426 ? 1.76388  19.41546  -29.71380  1.000 20.30904  ? 384 ASP A CG  1 
ATOM   2519 O  OD1 . ASP A 1 426 ? 2.14051  20.52918  -30.16492  1.000 22.69640  ? 384 ASP A OD1 1 
ATOM   2520 O  OD2 . ASP A 1 426 ? 1.73116  19.16157  -28.48718  1.000 21.49422  ? 384 ASP A OD2 1 
ATOM   2521 N  N   . SER A 1 427 ? 2.87886  19.27399  -33.16481  1.000 21.78848  ? 385 SER A N   1 
ATOM   2522 C  CA  . SER A 1 427 ? 3.64831  20.28577  -33.87562  1.000 29.96347  ? 385 SER A CA  1 
ATOM   2523 C  C   . SER A 1 427 ? 3.04019  21.68313  -33.72630  1.000 23.88199  ? 385 SER A C   1 
ATOM   2524 O  O   . SER A 1 427 ? 3.19461  22.52618  -34.61232  1.000 24.54246  ? 385 SER A O   1 
ATOM   2525 C  CB  . SER A 1 427 ? 3.75662  19.91566  -35.34870  1.000 29.11778  ? 385 SER A CB  1 
ATOM   2526 O  OG  . SER A 1 427 ? 2.45453  19.66423  -35.85049  1.000 28.23117  ? 385 SER A OG  1 
ATOM   2527 N  N   . SER A 1 428 ? 2.37164  21.93849  -32.60367  1.000 19.83958  ? 386 SER A N   1 
ATOM   2528 C  CA  . SER A 1 428 ? 1.87451  23.26724  -32.25308  1.000 24.92067  ? 386 SER A CA  1 
ATOM   2529 C  C   . SER A 1 428 ? 2.81702  23.95794  -31.28152  1.000 24.19213  ? 386 SER A C   1 
ATOM   2530 O  O   . SER A 1 428 ? 3.31487  23.35039  -30.33182  1.000 23.12584  ? 386 SER A O   1 
ATOM   2531 C  CB  . SER A 1 428 ? 0.48211  23.18961  -31.63626  1.000 20.59910  ? 386 SER A CB  1 
ATOM   2532 O  OG  . SER A 1 428 ? -0.39578 22.77465  -32.65226  1.000 25.48270  ? 386 SER A OG  1 
ATOM   2533 N  N   . PHE A 1 429 ? 3.05673  25.22936  -31.53356  1.000 22.80477  ? 387 PHE A N   1 
ATOM   2534 C  CA  . PHE A 1 429 ? 3.91601  26.05361  -30.70605  1.000 24.55457  ? 387 PHE A CA  1 
ATOM   2535 C  C   . PHE A 1 429 ? 3.16834  27.34413  -30.43385  1.000 30.25070  ? 387 PHE A C   1 
ATOM   2536 O  O   . PHE A 1 429 ? 2.12433  27.60584  -31.03719  1.000 25.39145  ? 387 PHE A O   1 
ATOM   2537 C  CB  . PHE A 1 429 ? 5.25479  26.32837  -31.40968  1.000 19.13597  ? 387 PHE A CB  1 
ATOM   2538 C  CG  . PHE A 1 429 ? 5.09253  27.05159  -32.70476  1.000 15.87478  ? 387 PHE A CG  1 
ATOM   2539 C  CD1 . PHE A 1 429 ? 5.00096  26.34675  -33.89443  1.000 19.24206  ? 387 PHE A CD1 1 
ATOM   2540 C  CD2 . PHE A 1 429 ? 5.02320  28.44179  -32.73838  1.000 17.55282  ? 387 PHE A CD2 1 
ATOM   2541 C  CE1 . PHE A 1 429 ? 4.82038  27.01701  -35.11535  1.000 20.27374  ? 387 PHE A CE1 1 
ATOM   2542 C  CE2 . PHE A 1 429 ? 4.87024  29.13162  -33.93736  1.000 17.10144  ? 387 PHE A CE2 1 
ATOM   2543 C  CZ  . PHE A 1 429 ? 4.77675  28.43860  -35.12743  1.000 19.98804  ? 387 PHE A CZ  1 
ATOM   2544 N  N   . SER A 1 430 ? 3.69616  28.16841  -29.52667  1.000 25.35247  ? 388 SER A N   1 
ATOM   2545 C  CA  . SER A 1 430 ? 2.95043  29.37105  -29.20079  1.000 30.01259  ? 388 SER A CA  1 
ATOM   2546 C  C   . SER A 1 430 ? 3.63382  30.67888  -29.58333  1.000 32.01414  ? 388 SER A C   1 
ATOM   2547 O  O   . SER A 1 430 ? 2.92800  31.67047  -29.75459  1.000 31.75622  ? 388 SER A O   1 
ATOM   2548 C  CB  . SER A 1 430 ? 2.57408  29.39621  -27.71072  1.000 29.58665  ? 388 SER A CB  1 
ATOM   2549 O  OG  . SER A 1 430 ? 3.66364  29.22576  -26.86498  1.000 42.79481  ? 388 SER A OG  1 
ATOM   2550 N  N   . VAL A 1 431 ? 4.95844  30.71260  -29.76613  1.000 25.10116  ? 389 VAL A N   1 
ATOM   2551 C  CA  . VAL A 1 431 ? 5.67627  31.94390  -30.11896  1.000 23.88580  ? 389 VAL A CA  1 
ATOM   2552 C  C   . VAL A 1 431 ? 6.77182  31.63038  -31.13666  1.000 24.74188  ? 389 VAL A C   1 
ATOM   2553 O  O   . VAL A 1 431 ? 7.54828  30.68206  -30.94821  1.000 21.77092  ? 389 VAL A O   1 
ATOM   2554 C  CB  . VAL A 1 431 ? 6.30416  32.63573  -28.88562  1.000 25.75281  ? 389 VAL A CB  1 
ATOM   2555 C  CG1 . VAL A 1 431 ? 7.14812  33.81996  -29.32292  1.000 23.31607  ? 389 VAL A CG1 1 
ATOM   2556 C  CG2 . VAL A 1 431 ? 5.25067  33.12389  -27.94694  1.000 23.18817  ? 389 VAL A CG2 1 
ATOM   2557 N  N   . LYS A 1 432 ? 6.83998  32.43055  -32.20606  1.000 16.67006  ? 390 LYS A N   1 
ATOM   2558 C  CA  . LYS A 1 432 ? 7.95623  32.39995  -33.14515  1.000 17.74133  ? 390 LYS A CA  1 
ATOM   2559 C  C   . LYS A 1 432 ? 8.60102  33.77994  -33.23598  1.000 20.63737  ? 390 LYS A C   1 
ATOM   2560 O  O   . LYS A 1 432 ? 7.91082  34.79381  -33.40754  1.000 19.77553  ? 390 LYS A O   1 
ATOM   2561 C  CB  . LYS A 1 432 ? 7.50503  31.95963  -34.53868  1.000 19.60619  ? 390 LYS A CB  1 
ATOM   2562 C  CG  . LYS A 1 432 ? 8.61930  32.08867  -35.59993  1.000 24.05082  ? 390 LYS A CG  1 
ATOM   2563 C  CD  . LYS A 1 432 ? 8.15814  31.68385  -37.01921  1.000 22.82138  ? 390 LYS A CD  1 
ATOM   2564 C  CE  . LYS A 1 432 ? 7.91791  30.16380  -37.08541  1.000 29.60549  ? 390 LYS A CE  1 
ATOM   2565 N  NZ  . LYS A 1 432 ? 8.06270  29.55925  -38.45788  1.000 27.89510  ? 390 LYS A NZ  1 
ATOM   2566 N  N   . GLN A 1 433 ? 9.92183  33.82465  -33.17686  1.000 21.77547  ? 391 GLN A N   1 
ATOM   2567 C  CA  . GLN A 1 433 ? 10.64902 35.06858  -33.35946  1.000 16.92952  ? 391 GLN A CA  1 
ATOM   2568 C  C   . GLN A 1 433 ? 11.60128 34.86066  -34.51389  1.000 17.01810  ? 391 GLN A C   1 
ATOM   2569 O  O   . GLN A 1 433 ? 12.43873 33.95984  -34.46287  1.000 19.43390  ? 391 GLN A O   1 
ATOM   2570 C  CB  . GLN A 1 433 ? 11.39570 35.47523  -32.09511  1.000 18.46420  ? 391 GLN A CB  1 
ATOM   2571 C  CG  . GLN A 1 433 ? 12.18496 36.79064  -32.25929  1.000 17.95760  ? 391 GLN A CG  1 
ATOM   2572 C  CD  . GLN A 1 433 ? 12.82888 37.22846  -30.98204  1.000 16.68436  ? 391 GLN A CD  1 
ATOM   2573 O  OE1 . GLN A 1 433 ? 12.53865 36.68471  -29.91880  1.000 20.52002  ? 391 GLN A OE1 1 
ATOM   2574 N  NE2 . GLN A 1 433 ? 13.71047 38.23342  -31.06516  1.000 16.92989  ? 391 GLN A NE2 1 
ATOM   2575 N  N   . ASP A 1 434 ? 11.41256 35.62510  -35.58356  1.000 13.43285  ? 392 ASP A N   1 
ATOM   2576 C  CA  . ASP A 1 434 ? 12.31479 35.55558  -36.72493  1.000 23.21781  ? 392 ASP A CA  1 
ATOM   2577 C  C   . ASP A 1 434 ? 13.69541 36.07569  -36.36386  1.000 16.62363  ? 392 ASP A C   1 
ATOM   2578 O  O   . ASP A 1 434 ? 13.83735 37.05646  -35.62868  1.000 17.16124  ? 392 ASP A O   1 
ATOM   2579 C  CB  . ASP A 1 434 ? 11.79125 36.36506  -37.90659  1.000 19.00046  ? 392 ASP A CB  1 
ATOM   2580 C  CG  . ASP A 1 434 ? 10.63769 35.69553  -38.58746  1.000 29.50034  ? 392 ASP A CG  1 
ATOM   2581 O  OD1 . ASP A 1 434 ? 10.29329 34.55588  -38.19297  1.000 27.87487  ? 392 ASP A OD1 1 
ATOM   2582 O  OD2 . ASP A 1 434 ? 10.09703 36.28477  -39.54057  1.000 38.92428  ? 392 ASP A OD2 1 
ATOM   2583 N  N   . ILE A 1 435 ? 14.71128 35.41883  -36.91238  1.000 17.76322  ? 393 ILE A N   1 
ATOM   2584 C  CA  . ILE A 1 435 ? 16.10637 35.78401  -36.71803  1.000 14.19257  ? 393 ILE A CA  1 
ATOM   2585 C  C   . ILE A 1 435 ? 16.79980 36.05594  -38.04777  1.000 16.13367  ? 393 ILE A C   1 
ATOM   2586 O  O   . ILE A 1 435 ? 17.47525 37.07296  -38.20990  1.000 23.90578  ? 393 ILE A O   1 
ATOM   2587 C  CB  . ILE A 1 435 ? 16.85490 34.71230  -35.90928  1.000 15.86685  ? 393 ILE A CB  1 
ATOM   2588 C  CG1 . ILE A 1 435 ? 16.18207 34.57409  -34.54221  1.000 17.71376  ? 393 ILE A CG1 1 
ATOM   2589 C  CG2 . ILE A 1 435 ? 18.37022 35.08136  -35.78671  1.000 13.20054  ? 393 ILE A CG2 1 
ATOM   2590 C  CD1 . ILE A 1 435 ? 16.41357 35.76145  -33.59684  1.000 20.94587  ? 393 ILE A CD1 1 
ATOM   2591 N  N   . VAL A 1 436 ? 16.62589 35.16476  -39.02070  1.000 17.52749  ? 394 VAL A N   1 
ATOM   2592 C  CA  . VAL A 1 436 ? 17.16551 35.36075  -40.36313  1.000 17.38220  ? 394 VAL A CA  1 
ATOM   2593 C  C   . VAL A 1 436 ? 16.08313 34.95955  -41.36287  1.000 22.88624  ? 394 VAL A C   1 
ATOM   2594 O  O   . VAL A 1 436 ? 15.45984 33.90153  -41.21546  1.000 17.27652  ? 394 VAL A O   1 
ATOM   2595 C  CB  . VAL A 1 436 ? 18.45963 34.54403  -40.58017  1.000 18.33034  ? 394 VAL A CB  1 
ATOM   2596 C  CG1 . VAL A 1 436 ? 18.99396 34.75763  -41.96272  1.000 18.57616  ? 394 VAL A CG1 1 
ATOM   2597 C  CG2 . VAL A 1 436 ? 19.52337 34.94870  -39.56889  1.000 12.10625  ? 394 VAL A CG2 1 
ATOM   2598 N  N   . GLY A 1 437 ? 15.84511 35.79884  -42.37644  1.000 19.60010  ? 395 GLY A N   1 
ATOM   2599 C  CA  . GLY A 1 437 ? 14.76858 35.50961  -43.31085  1.000 23.66208  ? 395 GLY A CA  1 
ATOM   2600 C  C   . GLY A 1 437 ? 15.01192 34.24222  -44.11947  1.000 25.03800  ? 395 GLY A C   1 
ATOM   2601 O  O   . GLY A 1 437 ? 16.14893 33.84654  -44.38050  1.000 18.34280  ? 395 GLY A O   1 
ATOM   2602 N  N   . ILE A 1 438 ? 13.90107 33.65123  -44.59649  1.000 21.32408  ? 396 ILE A N   1 
ATOM   2603 C  CA  . ILE A 1 438 ? 13.92921 32.34302  -45.25462  1.000 27.32863  ? 396 ILE A CA  1 
ATOM   2604 C  C   . ILE A 1 438 ? 14.88028 32.32149  -46.44206  1.000 25.08013  ? 396 ILE A C   1 
ATOM   2605 O  O   . ILE A 1 438 ? 15.50428 31.29533  -46.72625  1.000 21.98819  ? 396 ILE A O   1 
ATOM   2606 C  CB  . ILE A 1 438 ? 12.49266 31.93623  -45.68397  1.000 24.12755  ? 396 ILE A CB  1 
ATOM   2607 C  CG1 . ILE A 1 438 ? 12.47092 30.57287  -46.37032  1.000 34.47647  ? 396 ILE A CG1 1 
ATOM   2608 C  CG2 . ILE A 1 438 ? 11.90625 32.94304  -46.65370  1.000 21.00410  ? 396 ILE A CG2 1 
ATOM   2609 C  CD1 . ILE A 1 438 ? 12.99667 29.45249  -45.55590  1.000 32.14386  ? 396 ILE A CD1 1 
ATOM   2610 N  N   . ASN A 1 439 ? 15.04231 33.43748  -47.13440  1.000 19.90951  ? 397 ASN A N   1 
ATOM   2611 C  CA  . ASN A 1 439 ? 15.88280 33.42231  -48.32204  1.000 23.58561  ? 397 ASN A CA  1 
ATOM   2612 C  C   . ASN A 1 439 ? 17.34341 33.71552  -48.01621  1.000 30.68079  ? 397 ASN A C   1 
ATOM   2613 O  O   . ASN A 1 439 ? 18.16031 33.76169  -48.93590  1.000 33.65814  ? 397 ASN A O   1 
ATOM   2614 C  CB  . ASN A 1 439 ? 15.33228 34.40301  -49.35260  1.000 28.69415  ? 397 ASN A CB  1 
ATOM   2615 C  CG  . ASN A 1 439 ? 14.04742 33.89543  -49.99866  1.000 37.37623  ? 397 ASN A CG  1 
ATOM   2616 O  OD1 . ASN A 1 439 ? 13.78927 32.66920  -50.08109  1.000 35.64089  ? 397 ASN A OD1 1 
ATOM   2617 N  ND2 . ASN A 1 439 ? 13.21652 34.82775  -50.41699  1.000 34.86745  ? 397 ASN A ND2 1 
ATOM   2618 N  N   . GLU A 1 440 ? 17.69911 33.84178  -46.74861  1.000 27.32216  ? 398 GLU A N   1 
ATOM   2619 C  CA  . GLU A 1 440 ? 19.01765 34.28718  -46.35894  1.000 22.46754  ? 398 GLU A CA  1 
ATOM   2620 C  C   . GLU A 1 440 ? 19.81348 33.10509  -45.82626  1.000 20.51154  ? 398 GLU A C   1 
ATOM   2621 O  O   . GLU A 1 440 ? 19.24243 32.16125  -45.27326  1.000 17.56703  ? 398 GLU A O   1 
ATOM   2622 C  CB  . GLU A 1 440 ? 18.89240 35.37386  -45.30572  1.000 24.40800  ? 398 GLU A CB  1 
ATOM   2623 C  CG  . GLU A 1 440 ? 18.48905 36.71360  -45.89260  1.000 28.19934  ? 398 GLU A CG  1 
ATOM   2624 C  CD  . GLU A 1 440 ? 19.53428 37.22677  -46.86734  1.000 38.92311  ? 398 GLU A CD  1 
ATOM   2625 O  OE1 . GLU A 1 440 ? 20.70464 36.70578  -46.86057  1.000 45.26896  ? 398 GLU A OE1 1 
ATOM   2626 O  OE2 . GLU A 1 440 ? 19.18526 38.16652  -47.61407  1.000 52.18328  ? 398 GLU A OE2 1 
ATOM   2627 N  N   . TRP A 1 441 ? 21.12618 33.14101  -46.06406  1.000 21.55311  ? 399 TRP A N   1 
ATOM   2628 C  CA  . TRP A 1 441 ? 22.02051 32.05127  -45.66577  1.000 14.18528  ? 399 TRP A CA  1 
ATOM   2629 C  C   . TRP A 1 441 ? 22.12345 31.99704  -44.16015  1.000 19.69715  ? 399 TRP A C   1 
ATOM   2630 O  O   . TRP A 1 441 ? 22.21784 33.03027  -43.49862  1.000 15.42197  ? 399 TRP A O   1 
ATOM   2631 C  CB  . TRP A 1 441 ? 23.40779 32.24784  -46.27556  1.000 24.81978  ? 399 TRP A CB  1 
ATOM   2632 C  CG  . TRP A 1 441 ? 23.39139 32.39206  -47.77219  1.000 20.57344  ? 399 TRP A CG  1 
ATOM   2633 C  CD1 . TRP A 1 441 ? 23.58732 33.53826  -48.50749  1.000 27.74161  ? 399 TRP A CD1 1 
ATOM   2634 C  CD2 . TRP A 1 441 ? 23.08109 31.35920  -48.71126  1.000 20.66017  ? 399 TRP A CD2 1 
ATOM   2635 N  NE1 . TRP A 1 441 ? 23.48345 33.25004  -49.85327  1.000 26.06364  ? 399 TRP A NE1 1 
ATOM   2636 C  CE2 . TRP A 1 441 ? 23.16267 31.92468  -50.00087  1.000 22.99158  ? 399 TRP A CE2 1 
ATOM   2637 C  CE3 . TRP A 1 441 ? 22.76465 30.00757  -48.58653  1.000 24.05697  ? 399 TRP A CE3 1 
ATOM   2638 C  CZ2 . TRP A 1 441 ? 22.93559 31.17860  -51.15844  1.000 26.87704  ? 399 TRP A CZ2 1 
ATOM   2639 C  CZ3 . TRP A 1 441 ? 22.51834 29.26468  -49.74156  1.000 25.75262  ? 399 TRP A CZ3 1 
ATOM   2640 C  CH2 . TRP A 1 441 ? 22.62791 29.85212  -51.00828  1.000 22.74569  ? 399 TRP A CH2 1 
ATOM   2641 N  N   . SER A 1 442 ? 22.04420 30.79304  -43.60581  1.000 12.21373  ? 400 SER A N   1 
ATOM   2642 C  CA  . SER A 1 442 ? 22.35724 30.63998  -42.19668  1.000 12.67126  ? 400 SER A CA  1 
ATOM   2643 C  C   . SER A 1 442 ? 23.39541 29.51593  -42.04653  1.000 16.43272  ? 400 SER A C   1 
ATOM   2644 O  O   . SER A 1 442 ? 24.33909 29.43311  -42.84724  1.000 17.49277  ? 400 SER A O   1 
ATOM   2645 C  CB  . SER A 1 442 ? 21.07487 30.36555  -41.39954  1.000 13.01735  ? 400 SER A CB  1 
ATOM   2646 O  OG  . SER A 1 442 ? 20.46276 29.20328  -41.89731  1.000 21.33419  ? 400 SER A OG  1 
ATOM   2647 N  N   . GLY A 1 443 ? 23.26975 28.68130  -41.01634  1.000 16.32688  ? 401 GLY A N   1 
ATOM   2648 C  CA  . GLY A 1 443 ? 24.29932 27.68481  -40.74574  1.000 18.33637  ? 401 GLY A CA  1 
ATOM   2649 C  C   . GLY A 1 443 ? 24.31437 27.15008  -39.33209  1.000 21.24282  ? 401 GLY A C   1 
ATOM   2650 O  O   . GLY A 1 443 ? 23.26111 26.94320  -38.72985  1.000 17.98783  ? 401 GLY A O   1 
ATOM   2651 N  N   . TYR A 1 444 ? 25.50970 26.87770  -38.80701  1.000 16.28244  ? 402 TYR A N   1 
ATOM   2652 C  CA  . TYR A 1 444 ? 25.64198 26.33506  -37.47127  1.000 14.42258  ? 402 TYR A CA  1 
ATOM   2653 C  C   . TYR A 1 444 ? 25.03117 27.29182  -36.44343  1.000 16.53658  ? 402 TYR A C   1 
ATOM   2654 O  O   . TYR A 1 444 ? 24.95254 28.51211  -36.65057  1.000 16.33337  ? 402 TYR A O   1 
ATOM   2655 C  CB  . TYR A 1 444 ? 27.13045 26.09891  -37.14678  1.000 18.18480  ? 402 TYR A CB  1 
ATOM   2656 C  CG  . TYR A 1 444 ? 27.69434 24.77373  -37.63412  1.000 13.47561  ? 402 TYR A CG  1 
ATOM   2657 C  CD1 . TYR A 1 444 ? 27.10228 24.06479  -38.67966  1.000 21.76395  ? 402 TYR A CD1 1 
ATOM   2658 C  CD2 . TYR A 1 444 ? 28.76460 24.18164  -36.97799  1.000 22.85561  ? 402 TYR A CD2 1 
ATOM   2659 C  CE1 . TYR A 1 444 ? 27.61217 22.82034  -39.09551  1.000 21.53085  ? 402 TYR A CE1 1 
ATOM   2660 C  CE2 . TYR A 1 444 ? 29.26408 22.96596  -37.37579  1.000 16.24980  ? 402 TYR A CE2 1 
ATOM   2661 C  CZ  . TYR A 1 444 ? 28.67286 22.28194  -38.42376  1.000 19.49443  ? 402 TYR A CZ  1 
ATOM   2662 O  OH  . TYR A 1 444 ? 29.20070 21.06439  -38.81184  1.000 20.81378  ? 402 TYR A OH  1 
ATOM   2663 N  N   . SER A 1 445 ? 24.63122 26.74485  -35.29706  1.000 13.52558  ? 403 SER A N   1 
ATOM   2664 C  CA  . SER A 1 445 ? 24.20128 27.61792  -34.21046  1.000 10.86744  ? 403 SER A CA  1 
ATOM   2665 C  C   . SER A 1 445 ? 24.49071 26.91297  -32.89839  1.000 15.47897  ? 403 SER A C   1 
ATOM   2666 O  O   . SER A 1 445 ? 24.58346 25.68386  -32.83899  1.000 16.64614  ? 403 SER A O   1 
ATOM   2667 C  CB  . SER A 1 445 ? 22.69747 27.99252  -34.33352  1.000 14.13195  ? 403 SER A CB  1 
ATOM   2668 O  OG  . SER A 1 445 ? 21.85114 26.83973  -34.38295  1.000 14.42072  ? 403 SER A OG  1 
ATOM   2669 N  N   . GLY A 1 446 ? 24.60606 27.68007  -31.82905  1.000 15.08426  ? 404 GLY A N   1 
ATOM   2670 C  CA  . GLY A 1 446 ? 24.91172 27.01361  -30.57990  1.000 15.16024  ? 404 GLY A CA  1 
ATOM   2671 C  C   . GLY A 1 446 ? 24.49385 27.86247  -29.40891  1.000 18.12431  ? 404 GLY A C   1 
ATOM   2672 O  O   . GLY A 1 446 ? 24.26877 29.06985  -29.54553  1.000 16.19175  ? 404 GLY A O   1 
ATOM   2673 N  N   . SER A 1 447 ? 24.38805 27.21478  -28.24665  1.000 12.65140  ? 405 SER A N   1 
ATOM   2674 C  CA  . SER A 1 447 ? 24.06253 27.94399  -27.03683  1.000 18.22982  ? 405 SER A CA  1 
ATOM   2675 C  C   . SER A 1 447 ? 25.31942 28.53482  -26.41427  1.000 25.39441  ? 405 SER A C   1 
ATOM   2676 O  O   . SER A 1 447 ? 26.43713 27.99592  -26.55144  1.000 16.84633  ? 405 SER A O   1 
ATOM   2677 C  CB  . SER A 1 447 ? 23.40403 27.02581  -26.01094  1.000 20.28376  ? 405 SER A CB  1 
ATOM   2678 O  OG  . SER A 1 447 ? 24.30312 25.96552  -25.68268  1.000 23.37880  ? 405 SER A OG  1 
ATOM   2679 N  N   . PHE A 1 448 ? 25.11838 29.63145  -25.69064  1.000 19.66904  ? 406 PHE A N   1 
ATOM   2680 C  CA  . PHE A 1 448 ? 26.06499 30.05078  -24.66562  1.000 17.92872  ? 406 PHE A CA  1 
ATOM   2681 C  C   . PHE A 1 448 ? 25.26026 30.70223  -23.55805  1.000 22.94846  ? 406 PHE A C   1 
ATOM   2682 O  O   . PHE A 1 448 ? 24.07131 31.04439  -23.73693  1.000 18.21863  ? 406 PHE A O   1 
ATOM   2683 C  CB  . PHE A 1 448 ? 27.18591 30.95231  -25.21533  1.000 15.61690  ? 406 PHE A CB  1 
ATOM   2684 C  CG  . PHE A 1 448 ? 26.76430 32.33376  -25.62431  1.000 19.21881  ? 406 PHE A CG  1 
ATOM   2685 C  CD1 . PHE A 1 448 ? 26.99252 33.42606  -24.78623  1.000 14.31158  ? 406 PHE A CD1 1 
ATOM   2686 C  CD2 . PHE A 1 448 ? 26.21510 32.56454  -26.86814  1.000 22.23829  ? 406 PHE A CD2 1 
ATOM   2687 C  CE1 . PHE A 1 448 ? 26.65246 34.74744  -25.17896  1.000 17.81835  ? 406 PHE A CE1 1 
ATOM   2688 C  CE2 . PHE A 1 448 ? 25.88762 33.86145  -27.27552  1.000 20.27433  ? 406 PHE A CE2 1 
ATOM   2689 C  CZ  . PHE A 1 448 ? 26.11703 34.95905  -26.42320  1.000 19.81608  ? 406 PHE A CZ  1 
ATOM   2690 N  N   . VAL A 1 449 ? 25.86134 30.70935  -22.36569  1.000 17.18178  ? 407 VAL A N   1 
ATOM   2691 C  CA  . VAL A 1 449 ? 25.20292 31.26131  -21.19431  1.000 16.35698  ? 407 VAL A CA  1 
ATOM   2692 C  C   . VAL A 1 449 ? 25.99749 32.44689  -20.66273  1.000 21.14896  ? 407 VAL A C   1 
ATOM   2693 O  O   . VAL A 1 449 ? 27.19477 32.59452  -20.90872  1.000 19.52398  ? 407 VAL A O   1 
ATOM   2694 C  CB  . VAL A 1 449 ? 24.98730 30.22853  -20.06977  1.000 20.98862  ? 407 VAL A CB  1 
ATOM   2695 C  CG1 . VAL A 1 449 ? 23.95090 29.16157  -20.52205  1.000 17.76144  ? 407 VAL A CG1 1 
ATOM   2696 C  CG2 . VAL A 1 449 ? 26.31952 29.58814  -19.61296  1.000 14.62633  ? 407 VAL A CG2 1 
ATOM   2697 N  N   . GLN A 1 450 ? 25.31777 33.28224  -19.88459  1.000 17.83270  ? 408 GLN A N   1 
ATOM   2698 C  CA  . GLN A 1 450 ? 26.00078 34.25258  -19.04883  1.000 20.73543  ? 408 GLN A CA  1 
ATOM   2699 C  C   . GLN A 1 450 ? 25.64319 33.92695  -17.61172  1.000 21.55148  ? 408 GLN A C   1 
ATOM   2700 O  O   . GLN A 1 450 ? 24.45983 33.82875  -17.26852  1.000 20.99358  ? 408 GLN A O   1 
ATOM   2701 C  CB  . GLN A 1 450 ? 25.64427 35.69064  -19.44370  1.000 19.02150  ? 408 GLN A CB  1 
ATOM   2702 C  CG  . GLN A 1 450 ? 26.09748 36.04329  -20.87716  1.000 15.66959  ? 408 GLN A CG  1 
ATOM   2703 C  CD  . GLN A 1 450 ? 25.83584 37.52101  -21.27512  1.000 25.65467  ? 408 GLN A CD  1 
ATOM   2704 O  OE1 . GLN A 1 450 ? 24.81597 38.11519  -20.92274  1.000 22.55014  ? 408 GLN A OE1 1 
ATOM   2705 N  NE2 . GLN A 1 450 ? 26.74324 38.08453  -22.03292  1.000 22.34250  ? 408 GLN A NE2 1 
ATOM   2706 N  N   . HIS A 1 451 ? 26.67254 33.71266  -16.78995  1.000 18.97382  ? 409 HIS A N   1 
ATOM   2707 C  CA  . HIS A 1 451 ? 26.48313 33.29453  -15.41502  1.000 23.88978  ? 409 HIS A CA  1 
ATOM   2708 C  C   . HIS A 1 451 ? 26.12365 34.47624  -14.51732  1.000 27.09426  ? 409 HIS A C   1 
ATOM   2709 O  O   . HIS A 1 451 ? 26.44991 35.63904  -14.82812  1.000 26.91391  ? 409 HIS A O   1 
ATOM   2710 C  CB  . HIS A 1 451 ? 27.75173 32.64377  -14.89047  1.000 24.79173  ? 409 HIS A CB  1 
ATOM   2711 C  CG  . HIS A 1 451 ? 27.97800 31.27151  -15.41866  1.000 17.90010  ? 409 HIS A CG  1 
ATOM   2712 N  ND1 . HIS A 1 451 ? 27.89195 30.14890  -14.62530  1.000 17.96008  ? 409 HIS A ND1 1 
ATOM   2713 C  CD2 . HIS A 1 451 ? 28.28332 30.83998  -16.66198  1.000 14.30457  ? 409 HIS A CD2 1 
ATOM   2714 C  CE1 . HIS A 1 451 ? 28.15400 29.07962  -15.35684  1.000 22.99747  ? 409 HIS A CE1 1 
ATOM   2715 N  NE2 . HIS A 1 451 ? 28.39134 29.46986  -16.59809  1.000 21.91341  ? 409 HIS A NE2 1 
ATOM   2716 N  N   . PRO A 1 452 ? 25.47868 34.19645  -13.37617  1.000 22.58277  ? 410 PRO A N   1 
ATOM   2717 C  CA  . PRO A 1 452 ? 25.19370 35.27323  -12.41716  1.000 29.66906  ? 410 PRO A CA  1 
ATOM   2718 C  C   . PRO A 1 452 ? 26.43519 36.05013  -11.97647  1.000 28.25549  ? 410 PRO A C   1 
ATOM   2719 O  O   . PRO A 1 452 ? 26.33539 37.26549  -11.75543  1.000 29.50289  ? 410 PRO A O   1 
ATOM   2720 C  CB  . PRO A 1 452 ? 24.54242 34.52774  -11.25226  1.000 25.54671  ? 410 PRO A CB  1 
ATOM   2721 C  CG  . PRO A 1 452 ? 23.85878 33.30983  -11.94427  1.000 25.89830  ? 410 PRO A CG  1 
ATOM   2722 C  CD  . PRO A 1 452 ? 24.82597 32.91611  -13.00630  1.000 22.62043  ? 410 PRO A CD  1 
ATOM   2723 N  N   . GLU A 1 453 ? 27.60226 35.40137  -11.85116  1.000 26.56331  ? 411 GLU A N   1 
ATOM   2724 C  CA  . GLU A 1 453 ? 28.80894 36.12324  -11.43939  1.000 21.91233  ? 411 GLU A CA  1 
ATOM   2725 C  C   . GLU A 1 453 ? 29.15159 37.23804  -12.41376  1.000 23.69379  ? 411 GLU A C   1 
ATOM   2726 O  O   . GLU A 1 453 ? 29.85621 38.17393  -12.04128  1.000 26.16399  ? 411 GLU A O   1 
ATOM   2727 C  CB  . GLU A 1 453 ? 30.02544 35.18082  -11.32190  1.000 20.96815  ? 411 GLU A CB  1 
ATOM   2728 C  CG  . GLU A 1 453 ? 29.98227 34.19406  -10.13146  1.000 28.10584  ? 411 GLU A CG  1 
ATOM   2729 C  CD  . GLU A 1 453 ? 29.03298 32.97641  -10.35476  1.000 27.97423  ? 411 GLU A CD  1 
ATOM   2730 O  OE1 . GLU A 1 453 ? 28.34592 32.89050  -11.41128  1.000 24.69129  ? 411 GLU A OE1 1 
ATOM   2731 O  OE2 . GLU A 1 453 ? 28.95049 32.11010  -9.44846   1.000 26.65543  ? 411 GLU A OE2 1 
ATOM   2732 N  N   . MET A 1 454 ? 28.70744 37.13651  -13.66262  1.000 28.54651  ? 412 MET A N   1 
ATOM   2733 C  CA  . MET A 1 454 ? 28.93249 38.16761  -14.66649  1.000 27.01821  ? 412 MET A CA  1 
ATOM   2734 C  C   . MET A 1 454 ? 27.75075 39.12399  -14.80124  1.000 32.45354  ? 412 MET A C   1 
ATOM   2735 O  O   . MET A 1 454 ? 27.93540 40.33473  -14.92883  1.000 26.30485  ? 412 MET A O   1 
ATOM   2736 C  CB  . MET A 1 454 ? 29.24310 37.50474  -16.01477  1.000 32.16012  ? 412 MET A CB  1 
ATOM   2737 C  CG  . MET A 1 454 ? 29.47089 38.47541  -17.16152  1.000 45.32172  ? 412 MET A CG  1 
ATOM   2738 S  SD  . MET A 1 454 ? 29.31994 37.75229  -18.81738  1.000 46.02610  ? 412 MET A SD  1 
ATOM   2739 C  CE  . MET A 1 454 ? 30.91286 38.26729  -19.50492  1.000 33.33838  ? 412 MET A CE  1 
ATOM   2740 N  N   . THR A 1 455 ? 26.52934 38.61871  -14.74855  1.000 29.08189  ? 413 THR A N   1 
ATOM   2741 C  CA  . THR A 1 455 ? 25.37085 39.46666  -14.98142  1.000 30.68350  ? 413 THR A CA  1 
ATOM   2742 C  C   . THR A 1 455 ? 24.85243 40.15418  -13.73160  1.000 24.16038  ? 413 THR A C   1 
ATOM   2743 O  O   . THR A 1 455 ? 24.14420 41.15610  -13.85069  1.000 27.02347  ? 413 THR A O   1 
ATOM   2744 C  CB  . THR A 1 455 ? 24.23765 38.64612  -15.58290  1.000 30.11079  ? 413 THR A CB  1 
ATOM   2745 O  OG1 . THR A 1 455 ? 23.85960 37.63680  -14.64274  1.000 25.59995  ? 413 THR A OG1 1 
ATOM   2746 C  CG2 . THR A 1 455 ? 24.70795 37.99771  -16.86591  1.000 30.21604  ? 413 THR A CG2 1 
ATOM   2747 N  N   . GLY A 1 456 ? 25.14353 39.63286  -12.54484  1.000 23.40266  ? 414 GLY A N   1 
ATOM   2748 C  CA  . GLY A 1 456 ? 24.43586 40.09806  -11.36430  1.000 22.39440  ? 414 GLY A CA  1 
ATOM   2749 C  C   . GLY A 1 456 ? 23.02223 39.55967  -11.20176  1.000 30.63416  ? 414 GLY A C   1 
ATOM   2750 O  O   . GLY A 1 456 ? 22.39774 39.81554  -10.16711  1.000 31.97622  ? 414 GLY A O   1 
ATOM   2751 N  N   . LEU A 1 457 ? 22.50684 38.79958  -12.16864  1.000 26.31975  ? 415 LEU A N   1 
ATOM   2752 C  CA  . LEU A 1 457 ? 21.18160 38.21318  -12.03774  1.000 26.01537  ? 415 LEU A CA  1 
ATOM   2753 C  C   . LEU A 1 457 ? 21.20588 37.03539  -11.05784  1.000 24.99345  ? 415 LEU A C   1 
ATOM   2754 O  O   . LEU A 1 457 ? 22.25038 36.56730  -10.62846  1.000 30.34240  ? 415 LEU A O   1 
ATOM   2755 C  CB  . LEU A 1 457 ? 20.66627 37.76743  -13.40426  1.000 24.79129  ? 415 LEU A CB  1 
ATOM   2756 C  CG  . LEU A 1 457 ? 20.65515 38.85533  -14.47930  1.000 30.23479  ? 415 LEU A CG  1 
ATOM   2757 C  CD1 . LEU A 1 457 ? 20.52858 38.31295  -15.88004  1.000 22.61521  ? 415 LEU A CD1 1 
ATOM   2758 C  CD2 . LEU A 1 457 ? 19.56056 39.88095  -14.20421  1.000 25.33361  ? 415 LEU A CD2 1 
ATOM   2759 N  N   . ASP A 1 458 ? 20.02795 36.55667  -10.68167  1.000 34.32390  ? 416 ASP A N   1 
ATOM   2760 C  CA  . ASP A 1 458 ? 19.96693 35.38669  -9.81552   1.000 35.40016  ? 416 ASP A CA  1 
ATOM   2761 C  C   . ASP A 1 458 ? 19.67687 34.11857  -10.59902  1.000 38.04785  ? 416 ASP A C   1 
ATOM   2762 O  O   . ASP A 1 458 ? 19.25105 33.11768  -10.01557  1.000 38.95047  ? 416 ASP A O   1 
ATOM   2763 C  CB  . ASP A 1 458 ? 18.95318 35.58845  -8.69004   1.000 38.14114  ? 416 ASP A CB  1 
ATOM   2764 C  CG  . ASP A 1 458 ? 17.55709 35.88413  -9.20016   1.000 55.48112  ? 416 ASP A CG  1 
ATOM   2765 O  OD1 . ASP A 1 458 ? 16.63604 36.03899  -8.36100   1.000 69.35755  ? 416 ASP A OD1 1 
ATOM   2766 O  OD2 . ASP A 1 458 ? 17.36030 35.91308  -10.43501  1.000 62.23812  ? 416 ASP A OD2 1 
ATOM   2767 N  N   . CYS A 1 459 ? 19.90941 34.14407  -11.90880  1.000 28.74822  ? 417 CYS A N   1 
ATOM   2768 C  CA  . CYS A 1 459 ? 19.55624 33.03766  -12.78591  1.000 30.84675  ? 417 CYS A CA  1 
ATOM   2769 C  C   . CYS A 1 459 ? 20.58124 32.96647  -13.90596  1.000 26.85741  ? 417 CYS A C   1 
ATOM   2770 O  O   . CYS A 1 459 ? 21.32931 33.92157  -14.17180  1.000 25.04071  ? 417 CYS A O   1 
ATOM   2771 C  CB  . CYS A 1 459 ? 18.13857 33.19933  -13.37488  1.000 31.77387  ? 417 CYS A CB  1 
ATOM   2772 S  SG  . CYS A 1 459 ? 17.86166 34.83863  -14.18457  1.000 47.93653  ? 417 CYS A SG  1 
ATOM   2773 N  N   . MET A 1 460 ? 20.55146 31.83594  -14.58925  1.000 22.72702  ? 418 MET A N   1 
ATOM   2774 C  CA  . MET A 1 460 ? 21.44837 31.51794  -15.68944  1.000 21.26894  ? 418 MET A CA  1 
ATOM   2775 C  C   . MET A 1 460 ? 20.90009 32.11903  -16.97763  1.000 23.68025  ? 418 MET A C   1 
ATOM   2776 O  O   . MET A 1 460 ? 19.78653 31.79083  -17.40280  1.000 24.51389  ? 418 MET A O   1 
ATOM   2777 C  CB  . MET A 1 460 ? 21.57471 29.99872  -15.80827  1.000 20.67820  ? 418 MET A CB  1 
ATOM   2778 C  CG  . MET A 1 460 ? 22.67206 29.49502  -16.68409  1.000 15.66642  ? 418 MET A CG  1 
ATOM   2779 S  SD  . MET A 1 460 ? 24.37264 30.04403  -16.23949  1.000 23.10441  ? 418 MET A SD  1 
ATOM   2780 C  CE  . MET A 1 460 ? 24.60125 29.32931  -14.65433  1.000 18.02548  ? 418 MET A CE  1 
ATOM   2781 N  N   . ARG A 1 461 ? 21.66556 33.00554  -17.59675  1.000 24.45331  ? 419 ARG A N   1 
ATOM   2782 C  CA  . ARG A 1 461 ? 21.06143 33.62475  -18.77203  1.000 21.42013  ? 419 ARG A CA  1 
ATOM   2783 C  C   . ARG A 1 461 ? 21.36871 32.81248  -20.01646  1.000 18.57138  ? 419 ARG A C   1 
ATOM   2784 O  O   . ARG A 1 461 ? 22.54966 32.53948  -20.28721  1.000 22.19793  ? 419 ARG A O   1 
ATOM   2785 C  CB  . ARG A 1 461 ? 21.56959 35.04483  -18.97407  1.000 20.68274  ? 419 ARG A CB  1 
ATOM   2786 C  CG  . ARG A 1 461 ? 21.33511 35.50405  -20.39157  1.000 24.01010  ? 419 ARG A CG  1 
ATOM   2787 C  CD  . ARG A 1 461 ? 21.76052 36.91861  -20.62006  1.000 25.41054  ? 419 ARG A CD  1 
ATOM   2788 N  NE  . ARG A 1 461 ? 20.75767 37.81926  -20.09458  1.000 25.31709  ? 419 ARG A NE  1 
ATOM   2789 C  CZ  . ARG A 1 461 ? 20.91890 39.12966  -19.94116  1.000 24.70040  ? 419 ARG A CZ  1 
ATOM   2790 N  NH1 . ARG A 1 461 ? 22.03086 39.73951  -20.30283  1.000 26.23336  ? 419 ARG A NH1 1 
ATOM   2791 N  NH2 . ARG A 1 461 ? 19.93614 39.84281  -19.40963  1.000 24.03708  ? 419 ARG A NH2 1 
ATOM   2792 N  N   . PRO A 1 462 ? 20.36061 32.46835  -20.82496  1.000 18.51498  ? 420 PRO A N   1 
ATOM   2793 C  CA  . PRO A 1 462 ? 20.60855 31.73741  -22.07322  1.000 17.84174  ? 420 PRO A CA  1 
ATOM   2794 C  C   . PRO A 1 462 ? 20.81896 32.67309  -23.24838  1.000 18.60402  ? 420 PRO A C   1 
ATOM   2795 O  O   . PRO A 1 462 ? 20.15643 33.71021  -23.38356  1.000 20.16623  ? 420 PRO A O   1 
ATOM   2796 C  CB  . PRO A 1 462 ? 19.30707 30.93110  -22.25238  1.000 15.38721  ? 420 PRO A CB  1 
ATOM   2797 C  CG  . PRO A 1 462 ? 18.24221 31.91964  -21.68607  1.000 14.62347  ? 420 PRO A CG  1 
ATOM   2798 C  CD  . PRO A 1 462 ? 18.91216 32.61548  -20.53872  1.000 18.61519  ? 420 PRO A CD  1 
ATOM   2799 N  N   . CYS A 1 463 ? 21.75224 32.28906  -24.12019  1.000 12.61635  ? 421 CYS A N   1 
ATOM   2800 C  CA  . CYS A 1 463 ? 22.05776 33.05955  -25.31349  1.000 15.16249  ? 421 CYS A CA  1 
ATOM   2801 C  C   . CYS A 1 463 ? 22.33705 32.08832  -26.44138  1.000 16.55329  ? 421 CYS A C   1 
ATOM   2802 O  O   . CYS A 1 463 ? 22.53913 30.90164  -26.22478  1.000 20.88727  ? 421 CYS A O   1 
ATOM   2803 C  CB  . CYS A 1 463 ? 23.26690 34.00839  -25.13526  1.000 13.45431  ? 421 CYS A CB  1 
ATOM   2804 S  SG  . CYS A 1 463 ? 23.21125 35.18796  -23.74264  1.000 18.29578  ? 421 CYS A SG  1 
ATOM   2805 N  N   . PHE A 1 464 ? 22.39460 32.60487  -27.66119  1.000 21.59766  ? 422 PHE A N   1 
ATOM   2806 C  CA  . PHE A 1 464 ? 22.77802 31.72395  -28.74030  1.000 18.99213  ? 422 PHE A CA  1 
ATOM   2807 C  C   . PHE A 1 464 ? 23.44452 32.52869  -29.83447  1.000 17.86940  ? 422 PHE A C   1 
ATOM   2808 O  O   . PHE A 1 464 ? 23.29575 33.75315  -29.93721  1.000 15.31153  ? 422 PHE A O   1 
ATOM   2809 C  CB  . PHE A 1 464 ? 21.58493 30.93945  -29.29023  1.000 17.01761  ? 422 PHE A CB  1 
ATOM   2810 C  CG  . PHE A 1 464 ? 20.61141 31.77780  -30.05205  1.000 16.47096  ? 422 PHE A CG  1 
ATOM   2811 C  CD1 . PHE A 1 464 ? 20.75261 31.96691  -31.42283  1.000 14.13809  ? 422 PHE A CD1 1 
ATOM   2812 C  CD2 . PHE A 1 464 ? 19.51301 32.32795  -29.40281  1.000 15.65725  ? 422 PHE A CD2 1 
ATOM   2813 C  CE1 . PHE A 1 464 ? 19.79236 32.77436  -32.15092  1.000 11.60463  ? 422 PHE A CE1 1 
ATOM   2814 C  CE2 . PHE A 1 464 ? 18.58214 33.11764  -30.10230  1.000 18.51913  ? 422 PHE A CE2 1 
ATOM   2815 C  CZ  . PHE A 1 464 ? 18.72665 33.34575  -31.45957  1.000 13.97916  ? 422 PHE A CZ  1 
ATOM   2816 N  N   . TRP A 1 465 ? 24.21170 31.82130  -30.63328  1.000 15.12809  ? 423 TRP A N   1 
ATOM   2817 C  CA  . TRP A 1 465 ? 24.85390 32.43598  -31.77101  1.000 13.98705  ? 423 TRP A CA  1 
ATOM   2818 C  C   . TRP A 1 465 ? 24.41518 31.67569  -33.00518  1.000 14.13634  ? 423 TRP A C   1 
ATOM   2819 O  O   . TRP A 1 465 ? 24.11927 30.47075  -32.94164  1.000 14.60472  ? 423 TRP A O   1 
ATOM   2820 C  CB  . TRP A 1 465 ? 26.40213 32.39725  -31.63283  1.000 15.11541  ? 423 TRP A CB  1 
ATOM   2821 C  CG  . TRP A 1 465 ? 26.96968 30.98196  -31.34724  1.000 12.46687  ? 423 TRP A CG  1 
ATOM   2822 C  CD1 . TRP A 1 465 ? 27.22984 30.42930  -30.13183  1.000 13.74025  ? 423 TRP A CD1 1 
ATOM   2823 C  CD2 . TRP A 1 465 ? 27.29170 29.98289  -32.32055  1.000 13.66536  ? 423 TRP A CD2 1 
ATOM   2824 N  NE1 . TRP A 1 465 ? 27.73796 29.14284  -30.28493  1.000 15.99484  ? 423 TRP A NE1 1 
ATOM   2825 C  CE2 . TRP A 1 465 ? 27.79857 28.85705  -31.62399  1.000 13.31482  ? 423 TRP A CE2 1 
ATOM   2826 C  CE3 . TRP A 1 465 ? 27.26057 29.95457  -33.71647  1.000 12.73209  ? 423 TRP A CE3 1 
ATOM   2827 C  CZ2 . TRP A 1 465 ? 28.23508 27.70786  -32.27634  1.000 11.27039  ? 423 TRP A CZ2 1 
ATOM   2828 C  CZ3 . TRP A 1 465 ? 27.71714 28.82826  -34.36942  1.000 13.01374  ? 423 TRP A CZ3 1 
ATOM   2829 C  CH2 . TRP A 1 465 ? 28.19206 27.70100  -33.64356  1.000 15.02488  ? 423 TRP A CH2 1 
ATOM   2830 N  N   . VAL A 1 466 ? 24.46763 32.36624  -34.14232  1.000 18.74292  ? 424 VAL A N   1 
ATOM   2831 C  CA  . VAL A 1 466 ? 24.20699 31.75845  -35.44056  1.000 18.83016  ? 424 VAL A CA  1 
ATOM   2832 C  C   . VAL A 1 466 ? 25.35695 32.09913  -36.37129  1.000 20.51169  ? 424 VAL A C   1 
ATOM   2833 O  O   . VAL A 1 466 ? 25.83806 33.24121  -36.38240  1.000 18.32816  ? 424 VAL A O   1 
ATOM   2834 C  CB  . VAL A 1 466 ? 22.88101 32.24667  -36.04319  1.000 14.60001  ? 424 VAL A CB  1 
ATOM   2835 C  CG1 . VAL A 1 466 ? 22.52475 31.44865  -37.31514  1.000 12.59980  ? 424 VAL A CG1 1 
ATOM   2836 C  CG2 . VAL A 1 466 ? 21.79507 32.19996  -34.98285  1.000 11.39635  ? 424 VAL A CG2 1 
ATOM   2837 N  N   . GLU A 1 467 ? 25.79587 31.10372  -37.14827  1.000 11.92766  ? 425 GLU A N   1 
ATOM   2838 C  CA  . GLU A 1 467 ? 26.82473 31.26484  -38.16550  1.000 18.19848  ? 425 GLU A CA  1 
ATOM   2839 C  C   . GLU A 1 467 ? 26.13784 31.40295  -39.51171  1.000 15.32391  ? 425 GLU A C   1 
ATOM   2840 O  O   . GLU A 1 467 ? 25.26815 30.59924  -39.84409  1.000 20.08108  ? 425 GLU A O   1 
ATOM   2841 C  CB  . GLU A 1 467 ? 27.75120 30.04614  -38.19736  1.000 11.24661  ? 425 GLU A CB  1 
ATOM   2842 C  CG  . GLU A 1 467 ? 28.71648 30.04414  -39.34215  1.000 15.29166  ? 425 GLU A CG  1 
ATOM   2843 C  CD  . GLU A 1 467 ? 29.25873 28.60822  -39.61922  1.000 23.81322  ? 425 GLU A CD  1 
ATOM   2844 O  OE1 . GLU A 1 467 ? 28.45653 27.65209  -39.78706  1.000 17.92547  ? 425 GLU A OE1 1 
ATOM   2845 O  OE2 . GLU A 1 467 ? 30.47612 28.44891  -39.63968  1.000 18.79806  ? 425 GLU A OE2 1 
ATOM   2846 N  N   . LEU A 1 468 ? 26.52315 32.39648  -40.27942  1.000 16.30486  ? 426 LEU A N   1 
ATOM   2847 C  CA  . LEU A 1 468 ? 25.87743 32.70047  -41.54999  1.000 12.24362  ? 426 LEU A CA  1 
ATOM   2848 C  C   . LEU A 1 468 ? 26.87258 32.32084  -42.62975  1.000 17.62997  ? 426 LEU A C   1 
ATOM   2849 O  O   . LEU A 1 468 ? 27.80505 33.09082  -42.91955  1.000 18.41521  ? 426 LEU A O   1 
ATOM   2850 C  CB  . LEU A 1 468 ? 25.47691 34.18419  -41.62755  1.000 9.34400   ? 426 LEU A CB  1 
ATOM   2851 C  CG  . LEU A 1 468 ? 24.71950 34.71009  -40.40351  1.000 15.16500  ? 426 LEU A CG  1 
ATOM   2852 C  CD1 . LEU A 1 468 ? 24.44667 36.24981  -40.44265  1.000 14.25426  ? 426 LEU A CD1 1 
ATOM   2853 C  CD2 . LEU A 1 468 ? 23.41461 33.94414  -40.23143  1.000 12.81751  ? 426 LEU A CD2 1 
ATOM   2854 N  N   . ILE A 1 469 ? 26.65079 31.14872  -43.24719  1.000 14.09604  ? 427 ILE A N   1 
ATOM   2855 C  CA  . ILE A 1 469 ? 27.63776 30.53191  -44.11252  1.000 14.47324  ? 427 ILE A CA  1 
ATOM   2856 C  C   . ILE A 1 469 ? 27.50107 31.07569  -45.52118  1.000 18.70234  ? 427 ILE A C   1 
ATOM   2857 O  O   . ILE A 1 469 ? 26.43127 30.98556  -46.12628  1.000 17.11724  ? 427 ILE A O   1 
ATOM   2858 C  CB  . ILE A 1 469 ? 27.49754 28.99991  -44.10982  1.000 16.39943  ? 427 ILE A CB  1 
ATOM   2859 C  CG1 . ILE A 1 469 ? 27.78602 28.40286  -42.72052  1.000 16.93489  ? 427 ILE A CG1 1 
ATOM   2860 C  CG2 . ILE A 1 469 ? 28.41297 28.40432  -45.15321  1.000 15.14141  ? 427 ILE A CG2 1 
ATOM   2861 C  CD1 . ILE A 1 469 ? 27.51600 26.81617  -42.64257  1.000 16.93833  ? 427 ILE A CD1 1 
ATOM   2862 N  N   . ARG A 1 470 ? 28.61737 31.55608  -46.07938  1.000 16.90178  ? 428 ARG A N   1 
ATOM   2863 C  CA  . ARG A 1 470 ? 28.67526 32.08432  -47.43613  1.000 13.72585  ? 428 ARG A CA  1 
ATOM   2864 C  C   . ARG A 1 470 ? 29.69373 31.32195  -48.27039  1.000 19.33792  ? 428 ARG A C   1 
ATOM   2865 O  O   . ARG A 1 470 ? 30.74390 30.87436  -47.77020  1.000 18.30177  ? 428 ARG A O   1 
ATOM   2866 C  CB  . ARG A 1 470 ? 29.05943 33.60434  -47.43223  1.000 12.65874  ? 428 ARG A CB  1 
ATOM   2867 C  CG  . ARG A 1 470 ? 28.08612 34.41610  -46.64317  1.000 15.72161  ? 428 ARG A CG  1 
ATOM   2868 C  CD  . ARG A 1 470 ? 26.61711 34.25596  -47.18849  1.000 14.69743  ? 428 ARG A CD  1 
ATOM   2869 N  NE  . ARG A 1 470 ? 26.48901 34.53738  -48.61988  1.000 15.22260  ? 428 ARG A NE  1 
ATOM   2870 C  CZ  . ARG A 1 470 ? 26.34309 35.75684  -49.13821  1.000 19.08764  ? 428 ARG A CZ  1 
ATOM   2871 N  NH1 . ARG A 1 470 ? 26.33415 36.83189  -48.37813  1.000 15.07303  ? 428 ARG A NH1 1 
ATOM   2872 N  NH2 . ARG A 1 470 ? 26.19321 35.89755  -50.45795  1.000 16.53512  ? 428 ARG A NH2 1 
ATOM   2873 N  N   . GLY A 1 471 ? 29.41158 31.22567  -49.56448  1.000 17.03557  ? 429 GLY A N   1 
ATOM   2874 C  CA  . GLY A 1 471 ? 30.40109 30.62511  -50.45840  1.000 17.27134  ? 429 GLY A CA  1 
ATOM   2875 C  C   . GLY A 1 471 ? 30.08018 29.20064  -50.89515  1.000 23.43786  ? 429 GLY A C   1 
ATOM   2876 O  O   . GLY A 1 471 ? 28.91248 28.84043  -51.10066  1.000 17.57560  ? 429 GLY A O   1 
ATOM   2877 N  N   . ARG A 1 472 ? 31.11261 28.37760  -51.02834  1.000 20.40282  ? 430 ARG A N   1 
ATOM   2878 C  CA  . ARG A 1 472 ? 30.92532 26.99486  -51.48058  1.000 22.53089  ? 430 ARG A CA  1 
ATOM   2879 C  C   . ARG A 1 472 ? 30.18950 26.18466  -50.42466  1.000 19.22357  ? 430 ARG A C   1 
ATOM   2880 O  O   . ARG A 1 472 ? 30.32691 26.45333  -49.22938  1.000 22.76958  ? 430 ARG A O   1 
ATOM   2881 C  CB  . ARG A 1 472 ? 32.27312 26.34431  -51.71413  1.000 23.00272  ? 430 ARG A CB  1 
ATOM   2882 C  CG  . ARG A 1 472 ? 32.95897 26.90591  -52.86410  1.000 26.11371  ? 430 ARG A CG  1 
ATOM   2883 C  CD  . ARG A 1 472 ? 34.39351 26.33295  -52.97291  1.000 30.43300  ? 430 ARG A CD  1 
ATOM   2884 N  NE  . ARG A 1 472 ? 34.42354 24.87798  -52.97926  1.000 38.05291  ? 430 ARG A NE  1 
ATOM   2885 C  CZ  . ARG A 1 472 ? 34.51728 24.18651  -54.10778  1.000 32.07501  ? 430 ARG A CZ  1 
ATOM   2886 N  NH1 . ARG A 1 472 ? 34.48385 24.79287  -55.28916  1.000 41.23209  ? 430 ARG A NH1 1 
ATOM   2887 N  NH2 . ARG A 1 472 ? 34.61055 22.86742  -54.05454  1.000 30.31005  ? 430 ARG A NH2 1 
ATOM   2888 N  N   . PRO A 1 473 ? 29.40988 25.16153  -50.83167  1.000 27.77622  ? 431 PRO A N   1 
ATOM   2889 C  CA  . PRO A 1 473 ? 29.11299 24.73424  -52.20164  1.000 24.59508  ? 431 PRO A CA  1 
ATOM   2890 C  C   . PRO A 1 473 ? 27.94057 25.51994  -52.79108  1.000 18.61316  ? 431 PRO A C   1 
ATOM   2891 O  O   . PRO A 1 473 ? 27.70374 25.43510  -53.99153  1.000 25.17955  ? 431 PRO A O   1 
ATOM   2892 C  CB  . PRO A 1 473 ? 28.75504 23.25950  -52.01588  1.000 24.01257  ? 431 PRO A CB  1 
ATOM   2893 C  CG  . PRO A 1 473 ? 28.00530 23.28177  -50.70800  1.000 25.05461  ? 431 PRO A CG  1 
ATOM   2894 C  CD  . PRO A 1 473 ? 28.68406 24.33395  -49.84899  1.000 22.08714  ? 431 PRO A CD  1 
ATOM   2895 N  N   . LYS A 1 474 ? 27.20465 26.31530  -52.00847  1.000 20.58983  ? 432 LYS A N   1 
ATOM   2896 C  CA  . LYS A 1 474 ? 25.97110 26.90641  -52.52869  1.000 23.33332  ? 432 LYS A CA  1 
ATOM   2897 C  C   . LYS A 1 474 ? 26.21444 28.06168  -53.48588  1.000 26.53102  ? 432 LYS A C   1 
ATOM   2898 O  O   . LYS A 1 474 ? 25.30849 28.41321  -54.25445  1.000 22.11364  ? 432 LYS A O   1 
ATOM   2899 C  CB  . LYS A 1 474 ? 25.07972 27.40886  -51.38292  1.000 25.67062  ? 432 LYS A CB  1 
ATOM   2900 C  CG  . LYS A 1 474 ? 24.54447 26.32456  -50.47090  1.000 27.71052  ? 432 LYS A CG  1 
ATOM   2901 C  CD  . LYS A 1 474 ? 23.89846 25.26197  -51.32531  1.000 32.73689  ? 432 LYS A CD  1 
ATOM   2902 C  CE  . LYS A 1 474 ? 23.57800 24.01839  -50.52010  1.000 46.77226  ? 432 LYS A CE  1 
ATOM   2903 N  NZ  . LYS A 1 474 ? 22.18955 23.60306  -50.84317  1.000 47.11417  ? 432 LYS A NZ  1 
ATOM   2904 N  N   . GLU A 1 475 ? 27.38961 28.68258  -53.44219  1.000 20.49676  ? 433 GLU A N   1 
ATOM   2905 C  CA  . GLU A 1 475 ? 27.67234 29.86327  -54.25499  1.000 19.39311  ? 433 GLU A CA  1 
ATOM   2906 C  C   . GLU A 1 475 ? 28.98076 29.66406  -55.00733  1.000 19.24174  ? 433 GLU A C   1 
ATOM   2907 O  O   . GLU A 1 475 ? 29.82835 28.84654  -54.62945  1.000 16.77171  ? 433 GLU A O   1 
ATOM   2908 C  CB  . GLU A 1 475 ? 27.73150 31.13516  -53.39331  1.000 18.05200  ? 433 GLU A CB  1 
ATOM   2909 C  CG  . GLU A 1 475 ? 26.51125 31.25698  -52.53062  1.000 16.70833  ? 433 GLU A CG  1 
ATOM   2910 C  CD  . GLU A 1 475 ? 26.57037 32.42228  -51.58568  1.000 19.33894  ? 433 GLU A CD  1 
ATOM   2911 O  OE1 . GLU A 1 475 ? 26.33025 33.53769  -52.06922  1.000 17.00562  ? 433 GLU A OE1 1 
ATOM   2912 O  OE2 . GLU A 1 475 ? 26.85215 32.23578  -50.37389  1.000 21.65201  ? 433 GLU A OE2 1 
ATOM   2913 N  N   . ASN A 1 476 ? 29.13214 30.41369  -56.08812  1.000 19.39935  ? 434 ASN A N   1 
ATOM   2914 C  CA  . ASN A 1 476 ? 30.21930 30.18400  -57.03064  1.000 18.10004  ? 434 ASN A CA  1 
ATOM   2915 C  C   . ASN A 1 476 ? 31.49145 30.92811  -56.58687  1.000 19.03384  ? 434 ASN A C   1 
ATOM   2916 O  O   . ASN A 1 476 ? 31.96780 31.84071  -57.23851  1.000 18.39328  ? 434 ASN A O   1 
ATOM   2917 C  CB  . ASN A 1 476 ? 29.77538 30.57467  -58.44383  1.000 14.42592  ? 434 ASN A CB  1 
ATOM   2918 C  CG  . ASN A 1 476 ? 28.84570 29.49724  -59.07755  1.000 21.24216  ? 434 ASN A CG  1 
ATOM   2919 O  OD1 . ASN A 1 476 ? 28.82551 28.37820  -58.61105  1.000 20.19857  ? 434 ASN A OD1 1 
ATOM   2920 N  ND2 . ASN A 1 476 ? 28.17322 29.81739  -60.17778  1.000 14.77305  ? 434 ASN A ND2 1 
ATOM   2921 N  N   . THR A 1 477 ? 32.02672 30.53252  -55.43616  1.000 13.99652  ? 435 THR A N   1 
ATOM   2922 C  CA  . THR A 1 477 ? 33.28176 31.07099  -54.93128  1.000 14.54354  ? 435 THR A CA  1 
ATOM   2923 C  C   . THR A 1 477 ? 34.28344 29.93933  -54.78517  1.000 19.59185  ? 435 THR A C   1 
ATOM   2924 O  O   . THR A 1 477 ? 33.93005 28.77021  -54.89967  1.000 13.80689  ? 435 THR A O   1 
ATOM   2925 C  CB  . THR A 1 477 ? 33.11288 31.73709  -53.57421  1.000 17.11579  ? 435 THR A CB  1 
ATOM   2926 O  OG1 . THR A 1 477 ? 32.58434 30.77302  -52.64696  1.000 17.72903  ? 435 THR A OG1 1 
ATOM   2927 C  CG2 . THR A 1 477 ? 32.21695 32.96838  -53.68622  1.000 13.82435  ? 435 THR A CG2 1 
ATOM   2928 N  N   . ILE A 1 478 ? 35.55494 30.28407  -54.52993  1.000 17.62619  ? 436 ILE A N   1 
ATOM   2929 C  CA  . ILE A 1 478 ? 36.52139 29.23810  -54.23307  1.000 15.66855  ? 436 ILE A CA  1 
ATOM   2930 C  C   . ILE A 1 478 ? 36.57239 28.94114  -52.74642  1.000 18.79449  ? 436 ILE A C   1 
ATOM   2931 O  O   . ILE A 1 478 ? 37.17266 27.93282  -52.35294  1.000 17.87981  ? 436 ILE A O   1 
ATOM   2932 C  CB  . ILE A 1 478 ? 37.93585 29.58202  -54.76731  1.000 19.79250  ? 436 ILE A CB  1 
ATOM   2933 C  CG1 . ILE A 1 478 ? 38.54757 30.75785  -53.99338  1.000 16.56689  ? 436 ILE A CG1 1 
ATOM   2934 C  CG2 . ILE A 1 478 ? 37.87626 29.84506  -56.29644  1.000 18.91866  ? 436 ILE A CG2 1 
ATOM   2935 C  CD1 . ILE A 1 478 ? 39.99841 31.16692  -54.47498  1.000 14.50259  ? 436 ILE A CD1 1 
ATOM   2936 N  N   . TRP A 1 479 ? 35.89829 29.73611  -51.91499  1.000 11.07194  ? 437 TRP A N   1 
ATOM   2937 C  CA  . TRP A 1 479 ? 36.09403 29.72016  -50.47570  1.000 12.15145  ? 437 TRP A CA  1 
ATOM   2938 C  C   . TRP A 1 479 ? 34.74755 29.54748  -49.76463  1.000 17.00013  ? 437 TRP A C   1 
ATOM   2939 O  O   . TRP A 1 479 ? 33.67117 29.66045  -50.36521  1.000 16.00585  ? 437 TRP A O   1 
ATOM   2940 C  CB  . TRP A 1 479 ? 36.79188 31.02661  -50.02330  1.000 16.30701  ? 437 TRP A CB  1 
ATOM   2941 C  CG  . TRP A 1 479 ? 36.03841 32.22911  -50.51709  1.000 15.86314  ? 437 TRP A CG  1 
ATOM   2942 C  CD1 . TRP A 1 479 ? 36.16570 32.83994  -51.74931  1.000 15.50285  ? 437 TRP A CD1 1 
ATOM   2943 C  CD2 . TRP A 1 479 ? 34.98871 32.92260  -49.83339  1.000 18.63655  ? 437 TRP A CD2 1 
ATOM   2944 N  NE1 . TRP A 1 479 ? 35.28017 33.89101  -51.84813  1.000 13.72019  ? 437 TRP A NE1 1 
ATOM   2945 C  CE2 . TRP A 1 479 ? 34.54619 33.97007  -50.69188  1.000 13.35539  ? 437 TRP A CE2 1 
ATOM   2946 C  CE3 . TRP A 1 479 ? 34.40298 32.79025  -48.56876  1.000 13.76280  ? 437 TRP A CE3 1 
ATOM   2947 C  CZ2 . TRP A 1 479 ? 33.54020 34.88594  -50.31664  1.000 17.55129  ? 437 TRP A CZ2 1 
ATOM   2948 C  CZ3 . TRP A 1 479 ? 33.41485 33.70281  -48.19758  1.000 12.68529  ? 437 TRP A CZ3 1 
ATOM   2949 C  CH2 . TRP A 1 479 ? 32.98688 34.72586  -49.07288  1.000 20.15427  ? 437 TRP A CH2 1 
ATOM   2950 N  N   . THR A 1 480 ? 34.81625 29.27672  -48.46329  1.000 16.25062  ? 438 THR A N   1 
ATOM   2951 C  CA  . THR A 1 480 ? 33.63017 29.19974  -47.61463  1.000 19.05940  ? 438 THR A CA  1 
ATOM   2952 C  C   . THR A 1 480 ? 33.96819 29.91353  -46.32756  1.000 19.65272  ? 438 THR A C   1 
ATOM   2953 O  O   . THR A 1 480 ? 35.03391 29.67994  -45.76080  1.000 18.46107  ? 438 THR A O   1 
ATOM   2954 C  CB  . THR A 1 480 ? 33.21246 27.73620  -47.29044  1.000 20.98166  ? 438 THR A CB  1 
ATOM   2955 O  OG1 . THR A 1 480 ? 32.93872 27.01476  -48.49274  1.000 20.68773  ? 438 THR A OG1 1 
ATOM   2956 C  CG2 . THR A 1 480 ? 31.96516 27.69111  -46.44784  1.000 18.40541  ? 438 THR A CG2 1 
ATOM   2957 N  N   . SER A 1 481 ? 33.09528 30.79794  -45.86588  1.000 15.28972  ? 439 SER A N   1 
ATOM   2958 C  CA  . SER A 1 481 ? 33.34198 31.36787  -44.55407  1.000 14.28449  ? 439 SER A CA  1 
ATOM   2959 C  C   . SER A 1 481 ? 31.99642 31.59189  -43.89812  1.000 18.19528  ? 439 SER A C   1 
ATOM   2960 O  O   . SER A 1 481 ? 30.95620 31.54486  -44.56228  1.000 20.73819  ? 439 SER A O   1 
ATOM   2961 C  CB  . SER A 1 481 ? 34.16896 32.65728  -44.67254  1.000 12.96445  ? 439 SER A CB  1 
ATOM   2962 O  OG  . SER A 1 481 ? 34.63439 33.02187  -43.39452  1.000 16.23637  ? 439 SER A OG  1 
ATOM   2963 N  N   . GLY A 1 482 ? 32.00560 31.83951  -42.59330  1.000 21.36291  ? 440 GLY A N   1 
ATOM   2964 C  CA  . GLY A 1 482 ? 30.80225 32.26274  -41.88569  1.000 22.64314  ? 440 GLY A CA  1 
ATOM   2965 C  C   . GLY A 1 482 ? 31.01194 33.61860  -41.22821  1.000 16.85180  ? 440 GLY A C   1 
ATOM   2966 O  O   . GLY A 1 482 ? 32.11061 33.95709  -40.83192  1.000 18.81148  ? 440 GLY A O   1 
ATOM   2967 N  N   . SER A 1 483 ? 29.95769 34.43003  -41.17876  1.000 23.04144  ? 441 SER A N   1 
ATOM   2968 C  CA  . SER A 1 483 ? 29.95722 35.51893  -40.20807  1.000 18.37867  ? 441 SER A CA  1 
ATOM   2969 C  C   . SER A 1 483 ? 29.00753 35.11949  -39.09191  1.000 18.84961  ? 441 SER A C   1 
ATOM   2970 O  O   . SER A 1 483 ? 28.43881 34.01001  -39.10633  1.000 17.65367  ? 441 SER A O   1 
ATOM   2971 C  CB  . SER A 1 483 ? 29.60519 36.86327  -40.84530  1.000 20.80166  ? 441 SER A CB  1 
ATOM   2972 O  OG  . SER A 1 483 ? 28.22665 36.92912  -41.15918  1.000 23.99553  ? 441 SER A OG  1 
ATOM   2973 N  N   . SER A 1 484 ? 28.85737 35.98518  -38.08818  1.000 18.25544  ? 442 SER A N   1 
ATOM   2974 C  CA  . SER A 1 484 ? 27.99945 35.59602  -36.97436  1.000 18.34834  ? 442 SER A CA  1 
ATOM   2975 C  C   . SER A 1 484 ? 27.10386 36.73704  -36.49849  1.000 23.47863  ? 442 SER A C   1 
ATOM   2976 O  O   . SER A 1 484 ? 27.37518 37.92790  -36.70472  1.000 15.50248  ? 442 SER A O   1 
ATOM   2977 C  CB  . SER A 1 484 ? 28.82095 35.07644  -35.78607  1.000 24.10313  ? 442 SER A CB  1 
ATOM   2978 O  OG  . SER A 1 484 ? 29.48812 36.13687  -35.12975  1.000 18.77457  ? 442 SER A OG  1 
ATOM   2979 N  N   . ILE A 1 485 ? 26.02111 36.31651  -35.83714  1.000 19.23791  ? 443 ILE A N   1 
ATOM   2980 C  CA  . ILE A 1 485 ? 25.09817 37.15827  -35.08735  1.000 14.49802  ? 443 ILE A CA  1 
ATOM   2981 C  C   . ILE A 1 485 ? 24.87560 36.40066  -33.78839  1.000 21.99510  ? 443 ILE A C   1 
ATOM   2982 O  O   . ILE A 1 485 ? 25.14621 35.20435  -33.71133  1.000 16.92299  ? 443 ILE A O   1 
ATOM   2983 C  CB  . ILE A 1 485 ? 23.78225 37.40804  -35.84830  1.000 16.96281  ? 443 ILE A CB  1 
ATOM   2984 C  CG1 . ILE A 1 485 ? 23.08776 36.06347  -36.20257  1.000 15.42715  ? 443 ILE A CG1 1 
ATOM   2985 C  CG2 . ILE A 1 485 ? 24.05346 38.29656  -37.10163  1.000 14.08815  ? 443 ILE A CG2 1 
ATOM   2986 C  CD1 . ILE A 1 485 ? 21.70386 36.24120  -36.93390  1.000 15.70631  ? 443 ILE A CD1 1 
ATOM   2987 N  N   . SER A 1 486 ? 24.49158 37.11865  -32.72949  1.000 20.32856  ? 444 SER A N   1 
ATOM   2988 C  CA  . SER A 1 486 ? 24.14010 36.43880  -31.49017  1.000 17.98415  ? 444 SER A CA  1 
ATOM   2989 C  C   . SER A 1 486 ? 23.03576 37.20752  -30.78827  1.000 19.44902  ? 444 SER A C   1 
ATOM   2990 O  O   . SER A 1 486 ? 22.83859 38.39991  -31.02593  1.000 15.23034  ? 444 SER A O   1 
ATOM   2991 C  CB  . SER A 1 486 ? 25.34274 36.25749  -30.55760  1.000 17.62029  ? 444 SER A CB  1 
ATOM   2992 O  OG  . SER A 1 486 ? 25.83218 37.50529  -30.02516  1.000 18.61420  ? 444 SER A OG  1 
ATOM   2993 N  N   . PHE A 1 487 ? 22.34750 36.50918  -29.88375  1.000 19.12786  ? 445 PHE A N   1 
ATOM   2994 C  CA  . PHE A 1 487 ? 21.18997 37.02498  -29.16320  1.000 22.81689  ? 445 PHE A CA  1 
ATOM   2995 C  C   . PHE A 1 487 ? 21.22716 36.51904  -27.73437  1.000 19.08567  ? 445 PHE A C   1 
ATOM   2996 O  O   . PHE A 1 487 ? 21.72605 35.42267  -27.47494  1.000 19.99373  ? 445 PHE A O   1 
ATOM   2997 C  CB  . PHE A 1 487 ? 19.88186 36.55821  -29.79874  1.000 12.55778  ? 445 PHE A CB  1 
ATOM   2998 C  CG  . PHE A 1 487 ? 19.71099 37.00845  -31.20342  1.000 12.94750  ? 445 PHE A CG  1 
ATOM   2999 C  CD1 . PHE A 1 487 ? 18.88118 38.08937  -31.49215  1.000 17.28699  ? 445 PHE A CD1 1 
ATOM   3000 C  CD2 . PHE A 1 487 ? 20.36273 36.35774  -32.23106  1.000 12.44750  ? 445 PHE A CD2 1 
ATOM   3001 C  CE1 . PHE A 1 487 ? 18.71693 38.52715  -32.77543  1.000 13.56543  ? 445 PHE A CE1 1 
ATOM   3002 C  CE2 . PHE A 1 487 ? 20.21969 36.78324  -33.51183  1.000 15.00968  ? 445 PHE A CE2 1 
ATOM   3003 C  CZ  . PHE A 1 487 ? 19.38413 37.89028  -33.79671  1.000 15.80580  ? 445 PHE A CZ  1 
ATOM   3004 N  N   . CYS A 1 488 ? 20.69181 37.30864  -26.80868  1.000 12.65232  ? 446 CYS A N   1 
ATOM   3005 C  CA  . CYS A 1 488 ? 20.48295 36.82031  -25.45189  1.000 19.21290  ? 446 CYS A CA  1 
ATOM   3006 C  C   . CYS A 1 488 ? 18.99985 36.82622  -25.12432  1.000 22.44775  ? 446 CYS A C   1 
ATOM   3007 O  O   . CYS A 1 488 ? 18.24975 37.65110  -25.64816  1.000 18.09447  ? 446 CYS A O   1 
ATOM   3008 C  CB  . CYS A 1 488 ? 21.24091 37.64695  -24.44347  1.000 16.13099  ? 446 CYS A CB  1 
ATOM   3009 S  SG  . CYS A 1 488 ? 23.04422 37.17311  -24.51480  1.000 29.23570  ? 446 CYS A SG  1 
ATOM   3010 N  N   . GLY A 1 489 ? 18.59847 35.91016  -24.24151  1.000 20.05741  ? 447 GLY A N   1 
ATOM   3011 C  CA  . GLY A 1 489 ? 17.21311 35.82043  -23.82699  1.000 20.63627  ? 447 GLY A CA  1 
ATOM   3012 C  C   . GLY A 1 489 ? 16.88196 36.87125  -22.77162  1.000 27.57244  ? 447 GLY A C   1 
ATOM   3013 O  O   . GLY A 1 489 ? 17.63286 37.06360  -21.80357  1.000 20.80247  ? 447 GLY A O   1 
ATOM   3014 N  N   . VAL A 1 490 ? 15.74119 37.54869  -22.94500  1.000 16.50579  ? 448 VAL A N   1 
ATOM   3015 C  CA  . VAL A 1 490 ? 15.32893 38.55106  -21.96855  1.000 22.03339  ? 448 VAL A CA  1 
ATOM   3016 C  C   . VAL A 1 490 ? 13.85485 38.38917  -21.65551  1.000 27.43969  ? 448 VAL A C   1 
ATOM   3017 O  O   . VAL A 1 490 ? 13.07084 37.86281  -22.45264  1.000 20.90054  ? 448 VAL A O   1 
ATOM   3018 C  CB  . VAL A 1 490 ? 15.59706 39.99872  -22.42806  1.000 20.31260  ? 448 VAL A CB  1 
ATOM   3019 C  CG1 . VAL A 1 490 ? 17.09807 40.20681  -22.66130  1.000 18.60741  ? 448 VAL A CG1 1 
ATOM   3020 C  CG2 . VAL A 1 490 ? 14.73724 40.35988  -23.64474  1.000 15.75492  ? 448 VAL A CG2 1 
ATOM   3021 N  N   . ASN A 1 491 ? 13.48835 38.85622  -20.47060  1.000 24.54592  ? 449 ASN A N   1 
ATOM   3022 C  CA  . ASN A 1 491 ? 12.08646 38.91317  -20.08620  1.000 19.53820  ? 449 ASN A CA  1 
ATOM   3023 C  C   . ASN A 1 491 ? 11.57477 40.34529  -20.18954  1.000 23.60621  ? 449 ASN A C   1 
ATOM   3024 O  O   . ASN A 1 491 ? 11.13038 40.92737  -19.21984  1.000 36.07328  ? 449 ASN A O   1 
ATOM   3025 C  CB  . ASN A 1 491 ? 11.90342 38.37151  -18.68273  1.000 24.58191  ? 449 ASN A CB  1 
ATOM   3026 C  CG  . ASN A 1 491 ? 10.48854 37.93799  -18.43926  1.000 33.01892  ? 449 ASN A CG  1 
ATOM   3027 O  OD1 . ASN A 1 491 ? 9.74086  37.73505  -19.38846  1.000 39.42855  ? 449 ASN A OD1 1 
ATOM   3028 N  ND2 . ASN A 1 491 ? 10.12102 37.75622  -17.18792  1.000 31.84610  ? 449 ASN A ND2 1 
ATOM   3029 N  N   . SER A 1 492 ? 11.70584 40.90825  -21.38798  1.000 24.59491  ? 450 SER A N   1 
ATOM   3030 C  CA  . SER A 1 492 ? 11.23777 42.25066  -21.72506  1.000 21.28464  ? 450 SER A CA  1 
ATOM   3031 C  C   . SER A 1 492 ? 10.94635 42.23660  -23.21932  1.000 25.91461  ? 450 SER A C   1 
ATOM   3032 O  O   . SER A 1 492 ? 11.06312 41.19718  -23.87607  1.000 26.34214  ? 450 SER A O   1 
ATOM   3033 C  CB  . SER A 1 492 ? 12.24561 43.33874  -21.31782  1.000 27.03959  ? 450 SER A CB  1 
ATOM   3034 O  OG  . SER A 1 492 ? 13.51695 43.17316  -21.90852  1.000 22.10150  ? 450 SER A OG  1 
ATOM   3035 N  N   . ASP A 1 493 ? 10.54226 43.37668  -23.75715  1.000 19.12892  ? 451 ASP A N   1 
ATOM   3036 C  CA  . ASP A 1 493 ? 10.06110 43.41215  -25.13042  1.000 21.72007  ? 451 ASP A CA  1 
ATOM   3037 C  C   . ASP A 1 493 ? 11.16208 43.13584  -26.13354  1.000 17.86034  ? 451 ASP A C   1 
ATOM   3038 O  O   . ASP A 1 493 ? 12.25965 43.67940  -26.03236  1.000 21.80434  ? 451 ASP A O   1 
ATOM   3039 C  CB  . ASP A 1 493 ? 9.46284  44.77809  -25.46007  1.000 21.01905  ? 451 ASP A CB  1 
ATOM   3040 C  CG  . ASP A 1 493 ? 8.14371  45.00095  -24.80505  1.000 30.23451  ? 451 ASP A CG  1 
ATOM   3041 O  OD1 . ASP A 1 493 ? 7.53685  43.98097  -24.35973  1.000 32.07881  ? 451 ASP A OD1 1 
ATOM   3042 O  OD2 . ASP A 1 493 ? 7.72085  46.19282  -24.75749  1.000 28.92334  ? 451 ASP A OD2 1 
ATOM   3043 N  N   . THR A 1 494 ? 10.82958 42.37343  -27.16978  1.000 14.99003  ? 452 THR A N   1 
ATOM   3044 C  CA  . THR A 1 494 ? 11.78207 42.04537  -28.21953  1.000 14.53692  ? 452 THR A CA  1 
ATOM   3045 C  C   . THR A 1 494 ? 11.06520 42.12200  -29.54498  1.000 19.71392  ? 452 THR A C   1 
ATOM   3046 O  O   . THR A 1 494 ? 9.86377  42.37488  -29.59559  1.000 18.04082  ? 452 THR A O   1 
ATOM   3047 C  CB  . THR A 1 494 ? 12.39856 40.64246  -28.02715  1.000 20.12740  ? 452 THR A CB  1 
ATOM   3048 O  OG1 . THR A 1 494 ? 11.35843 39.62902  -27.96470  1.000 19.95344  ? 452 THR A OG1 1 
ATOM   3049 C  CG2 . THR A 1 494 ? 13.23985 40.62500  -26.76915  1.000 19.27599  ? 452 THR A CG2 1 
ATOM   3050 N  N   . VAL A 1 495 ? 11.78355 41.82489  -30.63144  1.000 19.39388  ? 453 VAL A N   1 
ATOM   3051 C  CA  . VAL A 1 495 ? 11.17728 41.87894  -31.95374  1.000 17.24143  ? 453 VAL A CA  1 
ATOM   3052 C  C   . VAL A 1 495 ? 11.92096 40.92880  -32.87201  1.000 19.19808  ? 453 VAL A C   1 
ATOM   3053 O  O   . VAL A 1 495 ? 13.14049 40.74925  -32.76161  1.000 19.50559  ? 453 VAL A O   1 
ATOM   3054 C  CB  . VAL A 1 495 ? 11.18399 43.31785  -32.53887  1.000 22.41959  ? 453 VAL A CB  1 
ATOM   3055 C  CG1 . VAL A 1 495 ? 12.62229 43.78603  -32.80750  1.000 18.40985  ? 453 VAL A CG1 1 
ATOM   3056 C  CG2 . VAL A 1 495 ? 10.33559 43.39391  -33.84381  1.000 15.74498  ? 453 VAL A CG2 1 
ATOM   3057 N  N   . GLY A 1 496 ? 11.17640 40.34111  -33.80990  1.000 18.10176  ? 454 GLY A N   1 
ATOM   3058 C  CA  . GLY A 1 496 ? 11.77621 39.54776  -34.85617  1.000 24.86115  ? 454 GLY A CA  1 
ATOM   3059 C  C   . GLY A 1 496 ? 12.14834 40.39167  -36.06594  1.000 25.98935  ? 454 GLY A C   1 
ATOM   3060 O  O   . GLY A 1 496 ? 11.53545 41.40948  -36.35411  1.000 26.45113  ? 454 GLY A O   1 
ATOM   3061 N  N   . TRP A 1 497 ? 13.15391 39.93043  -36.79809  1.000 17.28986  ? 455 TRP A N   1 
ATOM   3062 C  CA  . TRP A 1 497 ? 13.59977 40.60890  -38.00291  1.000 20.13125  ? 455 TRP A CA  1 
ATOM   3063 C  C   . TRP A 1 497 ? 14.46340 39.61894  -38.75391  1.000 25.29715  ? 455 TRP A C   1 
ATOM   3064 O  O   . TRP A 1 497 ? 14.43515 38.41684  -38.46852  1.000 26.08383  ? 455 TRP A O   1 
ATOM   3065 C  CB  . TRP A 1 497 ? 14.40235 41.87844  -37.68116  1.000 16.69807  ? 455 TRP A CB  1 
ATOM   3066 C  CG  . TRP A 1 497 ? 14.33008 42.97009  -38.73182  1.000 24.51460  ? 455 TRP A CG  1 
ATOM   3067 C  CD1 . TRP A 1 497 ? 13.33050 43.16707  -39.65268  1.000 19.57909  ? 455 TRP A CD1 1 
ATOM   3068 C  CD2 . TRP A 1 497 ? 15.29893 44.01613  -38.95892  1.000 20.98647  ? 455 TRP A CD2 1 
ATOM   3069 N  NE1 . TRP A 1 497 ? 13.60653 44.27477  -40.42737  1.000 22.17922  ? 455 TRP A NE1 1 
ATOM   3070 C  CE2 . TRP A 1 497 ? 14.80449 44.82201  -40.02230  1.000 23.15903  ? 455 TRP A CE2 1 
ATOM   3071 C  CE3 . TRP A 1 497 ? 16.53158 44.34980  -38.37291  1.000 22.44452  ? 455 TRP A CE3 1 
ATOM   3072 C  CZ2 . TRP A 1 497 ? 15.50002 45.95937  -40.50052  1.000 22.56021  ? 455 TRP A CZ2 1 
ATOM   3073 C  CZ3 . TRP A 1 497 ? 17.22367 45.49079  -38.84641  1.000 21.84233  ? 455 TRP A CZ3 1 
ATOM   3074 C  CH2 . TRP A 1 497 ? 16.70610 46.27852  -39.90241  1.000 21.95669  ? 455 TRP A CH2 1 
ATOM   3075 N  N   . SER A 1 498 ? 15.25816 40.13296  -39.67790  1.000 20.94465  ? 456 SER A N   1 
ATOM   3076 C  CA  . SER A 1 498 ? 16.22998 39.34651  -40.40948  1.000 23.26403  ? 456 SER A CA  1 
ATOM   3077 C  C   . SER A 1 498 ? 17.55132 40.09166  -40.33674  1.000 25.20923  ? 456 SER A C   1 
ATOM   3078 O  O   . SER A 1 498 ? 17.63009 41.24115  -40.77332  1.000 22.92248  ? 456 SER A O   1 
ATOM   3079 C  CB  . SER A 1 498 ? 15.77267 39.16850  -41.84530  1.000 20.41142  ? 456 SER A CB  1 
ATOM   3080 O  OG  . SER A 1 498 ? 16.74101 38.52144  -42.59770  1.000 21.24197  ? 456 SER A OG  1 
ATOM   3081 N  N   . TRP A 1 499 ? 18.57032 39.46384  -39.74899  1.000 17.93071  ? 457 TRP A N   1 
ATOM   3082 C  CA  . TRP A 1 499 ? 19.90744 40.04396  -39.63612  1.000 17.29442  ? 457 TRP A CA  1 
ATOM   3083 C  C   . TRP A 1 499 ? 20.87773 39.17081  -40.41600  1.000 13.46696  ? 457 TRP A C   1 
ATOM   3084 O  O   . TRP A 1 499 ? 21.59664 38.34716  -39.82354  1.000 16.18346  ? 457 TRP A O   1 
ATOM   3085 C  CB  . TRP A 1 499 ? 20.33852 40.13324  -38.17852  1.000 16.60619  ? 457 TRP A CB  1 
ATOM   3086 C  CG  . TRP A 1 499 ? 19.63270 41.18643  -37.35611  1.000 22.22078  ? 457 TRP A CG  1 
ATOM   3087 C  CD1 . TRP A 1 499 ? 19.98467 42.50887  -37.23566  1.000 15.75727  ? 457 TRP A CD1 1 
ATOM   3088 C  CD2 . TRP A 1 499 ? 18.48943 41.00013  -36.50460  1.000 20.98631  ? 457 TRP A CD2 1 
ATOM   3089 N  NE1 . TRP A 1 499 ? 19.14243 43.14675  -36.37072  1.000 15.86313  ? 457 TRP A NE1 1 
ATOM   3090 C  CE2 . TRP A 1 499 ? 18.20783 42.26274  -35.91087  1.000 19.08065  ? 457 TRP A CE2 1 
ATOM   3091 C  CE3 . TRP A 1 499 ? 17.65555 39.90286  -36.21251  1.000 18.54565  ? 457 TRP A CE3 1 
ATOM   3092 C  CZ2 . TRP A 1 499 ? 17.13765 42.46295  -35.03298  1.000 16.67161  ? 457 TRP A CZ2 1 
ATOM   3093 C  CZ3 . TRP A 1 499 ? 16.60581 40.08626  -35.31753  1.000 18.66349  ? 457 TRP A CZ3 1 
ATOM   3094 C  CH2 . TRP A 1 499 ? 16.34480 41.37179  -34.74676  1.000 19.32546  ? 457 TRP A CH2 1 
ATOM   3095 N  N   . PRO A 1 500 ? 20.90703 39.28034  -41.72547  1.000 13.04314  ? 458 PRO A N   1 
ATOM   3096 C  CA  . PRO A 1 500 ? 21.70682 38.30801  -42.49278  1.000 17.69497  ? 458 PRO A CA  1 
ATOM   3097 C  C   . PRO A 1 500 ? 23.13498 38.77149  -42.69907  1.000 20.10286  ? 458 PRO A C   1 
ATOM   3098 O  O   . PRO A 1 500 ? 23.53305 39.82309  -42.17843  1.000 17.33312  ? 458 PRO A O   1 
ATOM   3099 C  CB  . PRO A 1 500 ? 20.96524 38.20157  -43.82509  1.000 18.11748  ? 458 PRO A CB  1 
ATOM   3100 C  CG  . PRO A 1 500 ? 20.35241 39.63375  -43.96467  1.000 14.50642  ? 458 PRO A CG  1 
ATOM   3101 C  CD  . PRO A 1 500 ? 20.08869 40.14486  -42.59356  1.000 13.46743  ? 458 PRO A CD  1 
ATOM   3102 N  N   . ASP A 1 501 ? 23.90430 37.96301  -43.44216  1.000 15.29743  ? 459 ASP A N   1 
ATOM   3103 C  CA  . ASP A 1 501 ? 25.33199 38.19765  -43.58230  1.000 18.89157  ? 459 ASP A CA  1 
ATOM   3104 C  C   . ASP A 1 501 ? 25.60342 39.49958  -44.33537  1.000 26.38074  ? 459 ASP A C   1 
ATOM   3105 O  O   . ASP A 1 501 ? 26.34737 40.36666  -43.85438  1.000 22.21440  ? 459 ASP A O   1 
ATOM   3106 C  CB  . ASP A 1 501 ? 25.99390 37.02464  -44.29953  1.000 12.28105  ? 459 ASP A CB  1 
ATOM   3107 C  CG  . ASP A 1 501 ? 27.44229 37.32437  -44.66881  1.000 19.99407  ? 459 ASP A CG  1 
ATOM   3108 O  OD1 . ASP A 1 501 ? 28.32053 37.30001  -43.76796  1.000 25.52109  ? 459 ASP A OD1 1 
ATOM   3109 O  OD2 . ASP A 1 501 ? 27.70864 37.62138  -45.84730  1.000 23.48022  ? 459 ASP A OD2 1 
ATOM   3110 N  N   . GLY A 1 502 ? 25.04426 39.63410  -45.54276  1.000 18.56840  ? 460 GLY A N   1 
ATOM   3111 C  CA  . GLY A 1 502 ? 25.07448 40.89976  -46.25636  1.000 18.53909  ? 460 GLY A CA  1 
ATOM   3112 C  C   . GLY A 1 502 ? 26.23309 41.07576  -47.21954  1.000 26.93503  ? 460 GLY A C   1 
ATOM   3113 O  O   . GLY A 1 502 ? 26.30560 42.11786  -47.88066  1.000 17.49480  ? 460 GLY A O   1 
ATOM   3114 N  N   . ALA A 1 503 ? 27.15471 40.10927  -47.31720  1.000 14.65263  ? 461 ALA A N   1 
ATOM   3115 C  CA  . ALA A 1 503 ? 28.24628 40.24809  -48.28399  1.000 13.49867  ? 461 ALA A CA  1 
ATOM   3116 C  C   . ALA A 1 503 ? 27.69525 40.02507  -49.68755  1.000 15.82120  ? 461 ALA A C   1 
ATOM   3117 O  O   . ALA A 1 503 ? 26.66892 39.36490  -49.87670  1.000 19.49796  ? 461 ALA A O   1 
ATOM   3118 C  CB  . ALA A 1 503 ? 29.40864 39.24393  -47.99669  1.000 11.50217  ? 461 ALA A CB  1 
ATOM   3119 N  N   . GLU A 1 504 ? 28.34727 40.64847  -50.66443  1.000 17.12438  ? 462 GLU A N   1 
ATOM   3120 C  CA  . GLU A 1 504 ? 28.02669 40.52048  -52.08144  1.000 20.60779  ? 462 GLU A CA  1 
ATOM   3121 C  C   . GLU A 1 504 ? 29.08526 39.61074  -52.71420  1.000 21.86189  ? 462 GLU A C   1 
ATOM   3122 O  O   . GLU A 1 504 ? 30.25457 40.00038  -52.84826  1.000 21.75572  ? 462 GLU A O   1 
ATOM   3123 C  CB  . GLU A 1 504 ? 27.99214 41.89898  -52.74830  1.000 14.37079  ? 462 GLU A CB  1 
ATOM   3124 C  CG  . GLU A 1 504 ? 27.01236 42.90190  -52.11979  1.000 32.10841  ? 462 GLU A CG  1 
ATOM   3125 C  CD  . GLU A 1 504 ? 25.56233 42.62951  -52.51495  1.000 58.67432  ? 462 GLU A CD  1 
ATOM   3126 O  OE1 . GLU A 1 504 ? 25.32546 42.19155  -53.67163  1.000 71.44087  ? 462 GLU A OE1 1 
ATOM   3127 O  OE2 . GLU A 1 504 ? 24.66327 42.81034  -51.66035  1.000 66.05270  ? 462 GLU A OE2 1 
ATOM   3128 N  N   . LEU A 1 505 ? 28.69870 38.41234  -53.04393  1.000 18.76344  ? 463 LEU A N   1 
ATOM   3129 C  CA  . LEU A 1 505 ? 29.58803 37.45047  -53.66777  1.000 19.61256  ? 463 LEU A CA  1 
ATOM   3130 C  C   . LEU A 1 505 ? 29.34551 37.45320  -55.15848  1.000 23.93136  ? 463 LEU A C   1 
ATOM   3131 O  O   . LEU A 1 505 ? 28.29396 37.89772  -55.61734  1.000 26.34701  ? 463 LEU A O   1 
ATOM   3132 C  CB  . LEU A 1 505 ? 29.36268 36.04343  -53.10004  1.000 17.03246  ? 463 LEU A CB  1 
ATOM   3133 C  CG  . LEU A 1 505 ? 30.16087 35.62633  -51.86916  1.000 22.06857  ? 463 LEU A CG  1 
ATOM   3134 C  CD1 . LEU A 1 505 ? 29.95894 36.63294  -50.74903  1.000 12.17271  ? 463 LEU A CD1 1 
ATOM   3135 C  CD2 . LEU A 1 505 ? 29.69795 34.23232  -51.41791  1.000 15.00705  ? 463 LEU A CD2 1 
ATOM   3136 N  N   . PRO A 1 506 ? 30.31550 37.03728  -55.96120  1.000 20.68887  ? 464 PRO A N   1 
ATOM   3137 C  CA  . PRO A 1 506 ? 31.66838 36.56663  -55.62254  1.000 19.15646  ? 464 PRO A CA  1 
ATOM   3138 C  C   . PRO A 1 506 ? 32.58219 37.71704  -55.17506  1.000 18.82803  ? 464 PRO A C   1 
ATOM   3139 O  O   . PRO A 1 506 ? 32.24372 38.89495  -55.30558  1.000 17.28488  ? 464 PRO A O   1 
ATOM   3140 C  CB  . PRO A 1 506 ? 32.14230 35.94481  -56.94009  1.000 21.50660  ? 464 PRO A CB  1 
ATOM   3141 C  CG  . PRO A 1 506 ? 31.45632 36.78340  -57.99543  1.000 26.07233  ? 464 PRO A CG  1 
ATOM   3142 C  CD  . PRO A 1 506 ? 30.06982 36.98838  -57.41154  1.000 20.53346  ? 464 PRO A CD  1 
ATOM   3143 N  N   . PHE A 1 507 ? 33.72453 37.38631  -54.59209  1.000 14.20794  ? 465 PHE A N   1 
ATOM   3144 C  CA  . PHE A 1 507 ? 34.76353 38.35687  -54.30847  1.000 18.49585  ? 465 PHE A CA  1 
ATOM   3145 C  C   . PHE A 1 507 ? 35.76490 38.39741  -55.46690  1.000 23.23341  ? 465 PHE A C   1 
ATOM   3146 O  O   . PHE A 1 507 ? 35.70124 37.59922  -56.40472  1.000 20.73768  ? 465 PHE A O   1 
ATOM   3147 C  CB  . PHE A 1 507 ? 35.45211 38.01038  -52.99868  1.000 14.88090  ? 465 PHE A CB  1 
ATOM   3148 C  CG  . PHE A 1 507 ? 34.70086 38.45325  -51.79124  1.000 20.22957  ? 465 PHE A CG  1 
ATOM   3149 C  CD1 . PHE A 1 507 ? 33.41263 39.02807  -51.91383  1.000 19.20432  ? 465 PHE A CD1 1 
ATOM   3150 C  CD2 . PHE A 1 507 ? 35.26741 38.31588  -50.52557  1.000 13.78398  ? 465 PHE A CD2 1 
ATOM   3151 C  CE1 . PHE A 1 507 ? 32.69534 39.46810  -50.78332  1.000 15.60922  ? 465 PHE A CE1 1 
ATOM   3152 C  CE2 . PHE A 1 507 ? 34.57236 38.75618  -49.38677  1.000 19.98815  ? 465 PHE A CE2 1 
ATOM   3153 C  CZ  . PHE A 1 507 ? 33.26786 39.34004  -49.52573  1.000 20.83664  ? 465 PHE A CZ  1 
ATOM   3154 N  N   . THR A 1 508 ? 36.68011 39.37284  -55.39083  1.000 18.01082  ? 466 THR A N   1 
ATOM   3155 C  CA  . THR A 1 508 ? 37.78655 39.53396  -56.34177  1.000 18.28039  ? 466 THR A CA  1 
ATOM   3156 C  C   . THR A 1 508 ? 38.56901 38.24335  -56.55928  1.000 19.86683  ? 466 THR A C   1 
ATOM   3157 O  O   . THR A 1 508 ? 38.84626 37.86686  -57.70321  1.000 19.14559  ? 466 THR A O   1 
ATOM   3158 C  CB  . THR A 1 508 ? 38.74438 40.60918  -55.81156  1.000 26.49901  ? 466 THR A CB  1 
ATOM   3159 O  OG1 . THR A 1 508 ? 38.00909 41.79953  -55.50826  1.000 28.28901  ? 466 THR A OG1 1 
ATOM   3160 C  CG2 . THR A 1 508 ? 39.85618 40.91349  -56.81612  1.000 29.46241  ? 466 THR A CG2 1 
ATOM   3161 N  N   . ILE A 1 509 ? 38.92895 37.54541  -55.47082  1.000 17.94764  ? 467 ILE A N   1 
ATOM   3162 C  CA  . ILE A 1 509 ? 39.74108 36.32474  -55.58482  1.000 16.01480  ? 467 ILE A CA  1 
ATOM   3163 C  C   . ILE A 1 509 ? 39.02633 35.24324  -56.37545  1.000 27.95057  ? 467 ILE A C   1 
ATOM   3164 O  O   . ILE A 1 509 ? 39.67060 34.32289  -56.89863  1.000 22.85139  ? 467 ILE A O   1 
ATOM   3165 C  CB  . ILE A 1 509 ? 40.14165 35.77321  -54.19750  1.000 21.88085  ? 467 ILE A CB  1 
ATOM   3166 C  CG1 . ILE A 1 509 ? 41.33187 34.78347  -54.31346  1.000 18.66696  ? 467 ILE A CG1 1 
ATOM   3167 C  CG2 . ILE A 1 509 ? 38.94139 35.06225  -53.51325  1.000 20.56539  ? 467 ILE A CG2 1 
ATOM   3168 C  CD1 . ILE A 1 509 ? 42.64356 35.29287  -54.97390  1.000 18.68904  ? 467 ILE A CD1 1 
ATOM   3169 N  N   . ASP A 1 510 ? 37.70132 35.32751  -56.47814  1.000 24.59885  ? 468 ASP A N   1 
ATOM   3170 C  CA  . ASP A 1 510 ? 36.95676 34.28350  -57.15047  1.000 28.78400  ? 468 ASP A CA  1 
ATOM   3171 C  C   . ASP A 1 510 ? 37.01350 34.41034  -58.65878  1.000 29.11955  ? 468 ASP A C   1 
ATOM   3172 O  O   . ASP A 1 510 ? 36.74798 33.43410  -59.35473  1.000 38.38338  ? 468 ASP A O   1 
ATOM   3173 C  CB  . ASP A 1 510 ? 35.51535 34.33015  -56.65841  1.000 19.46376  ? 468 ASP A CB  1 
ATOM   3174 C  CG  . ASP A 1 510 ? 35.43196 34.03503  -55.19576  1.000 19.94614  ? 468 ASP A CG  1 
ATOM   3175 O  OD1 . ASP A 1 510 ? 35.99970 32.98597  -54.78585  1.000 20.23193  ? 468 ASP A OD1 1 
ATOM   3176 O  OD2 . ASP A 1 510 ? 34.81844 34.83200  -54.45603  1.000 21.36439  ? 468 ASP A OD2 1 
ATOM   3177 N  N   . LYS A 1 511 ? 37.39224 35.56298  -59.17449  1.000 34.22900  ? 469 LYS A N   1 
ATOM   3178 C  CA  . LYS A 1 511 ? 37.54944 35.73274  -60.61160  1.000 49.41073  ? 469 LYS A CA  1 
ATOM   3179 C  C   . LYS A 1 511 ? 39.03601 35.54589  -60.96871  1.000 57.06922  ? 469 LYS A C   1 
ATOM   3180 O  O   . LYS A 1 511 ? 39.40334 35.36688  -62.12876  1.000 56.11712  ? 469 LYS A O   1 
ATOM   3181 C  CB  . LYS A 1 511 ? 37.03026 37.10351  -61.05609  1.000 47.28744  ? 469 LYS A CB  1 
ATOM   3182 C  CG  . LYS A 1 511 ? 35.49689 37.18543  -61.11624  1.000 56.25208  ? 469 LYS A CG  1 
ATOM   3183 C  CD  . LYS A 1 511 ? 34.84203 37.73559  -59.83808  1.000 44.97727  ? 469 LYS A CD  1 
ATOM   3184 C  CE  . LYS A 1 511 ? 34.88446 39.25975  -59.80845  1.000 51.59275  ? 469 LYS A CE  1 
ATOM   3185 N  NZ  . LYS A 1 511 ? 34.10911 39.82166  -58.66081  1.000 48.67055  ? 469 LYS A NZ  1 
ATOM   3186 N  N   . ILE B 1 108 ? 6.51045  -1.07050  -108.77544 1.000 48.67231  ? 66  ILE B N   1 
ATOM   3187 C  CA  . ILE B 1 108 ? 5.44997  -1.67246  -107.95388 1.000 68.53860  ? 66  ILE B CA  1 
ATOM   3188 C  C   . ILE B 1 108 ? 5.95879  -2.69418  -106.95868 1.000 73.37015  ? 66  ILE B C   1 
ATOM   3189 O  O   . ILE B 1 108 ? 5.72514  -2.54612  -105.75747 1.000 69.63045  ? 66  ILE B O   1 
ATOM   3190 C  CB  . ILE B 1 108 ? 4.34250  -2.36333  -108.79838 1.000 62.27678  ? 66  ILE B CB  1 
ATOM   3191 C  CG1 . ILE B 1 108 ? 3.53260  -1.34969  -109.60176 1.000 63.62520  ? 66  ILE B CG1 1 
ATOM   3192 C  CG2 . ILE B 1 108 ? 3.42994  -3.20441  -107.90938 1.000 54.61246  ? 66  ILE B CG2 1 
ATOM   3193 C  CD1 . ILE B 1 108 ? 2.33768  -1.96873  -110.33206 1.000 54.97450  ? 66  ILE B CD1 1 
ATOM   3194 N  N   . ASN B 1 109 ? 6.62366  -3.74660  -107.45506 1.000 75.32001  ? 67  ASN B N   1 
ATOM   3195 C  CA  . ASN B 1 109 ? 7.21243  -4.72528  -106.54683 1.000 73.54814  ? 67  ASN B CA  1 
ATOM   3196 C  C   . ASN B 1 109 ? 8.10375  -4.02278  -105.54795 1.000 67.41166  ? 67  ASN B C   1 
ATOM   3197 O  O   . ASN B 1 109 ? 8.12696  -4.36305  -104.35878 1.000 65.69371  ? 67  ASN B O   1 
ATOM   3198 C  CB  . ASN B 1 109 ? 8.02290  -5.77205  -107.31264 1.000 82.69720  ? 67  ASN B CB  1 
ATOM   3199 C  CG  . ASN B 1 109 ? 7.15901  -6.80451  -107.97617 1.000 87.49794  ? 67  ASN B CG  1 
ATOM   3200 O  OD1 . ASN B 1 109 ? 5.99024  -6.96112  -107.62846 1.000 87.79730  ? 67  ASN B OD1 1 
ATOM   3201 N  ND2 . ASN B 1 109 ? 7.73065  -7.53258  -108.93072 1.000 91.14295  ? 67  ASN B ND2 1 
ATOM   3202 N  N   . ASP B 1 110 ? 8.84385  -3.02918  -106.02460 1.000 68.14559  ? 68  ASP B N   1 
ATOM   3203 C  CA  . ASP B 1 110 ? 9.69371  -2.25446  -105.14136 1.000 72.31206  ? 68  ASP B CA  1 
ATOM   3204 C  C   . ASP B 1 110 ? 8.85243  -1.47806  -104.13573 1.000 68.43074  ? 68  ASP B C   1 
ATOM   3205 O  O   . ASP B 1 110 ? 9.09502  -1.54430  -102.92445 1.000 64.31481  ? 68  ASP B O   1 
ATOM   3206 C  CB  . ASP B 1 110 ? 10.58036 -1.33733  -105.98039 1.000 89.61880  ? 68  ASP B CB  1 
ATOM   3207 C  CG  . ASP B 1 110 ? 11.59322 -2.12048  -106.81107 1.000 90.28192  ? 68  ASP B CG  1 
ATOM   3208 O  OD1 . ASP B 1 110 ? 11.48491 -3.36739  -106.84842 1.000 91.87892  ? 68  ASP B OD1 1 
ATOM   3209 O  OD2 . ASP B 1 110 ? 12.48951 -1.49968  -107.42327 1.000 90.20068  ? 68  ASP B OD2 1 
ATOM   3210 N  N   . ASN B 1 111 ? 7.83744  -0.75429  -104.61704 1.000 65.81875  ? 69  ASN B N   1 
ATOM   3211 C  CA  . ASN B 1 111 ? 7.03147  0.05385   -103.70723 1.000 64.26332  ? 69  ASN B CA  1 
ATOM   3212 C  C   . ASN B 1 111 ? 6.29255  -0.80390  -102.68873 1.000 56.65698  ? 69  ASN B C   1 
ATOM   3213 O  O   . ASN B 1 111 ? 6.12936  -0.39211  -101.53689 1.000 57.53125  ? 69  ASN B O   1 
ATOM   3214 C  CB  . ASN B 1 111 ? 6.05144  0.90752   -104.50061 1.000 64.55888  ? 69  ASN B CB  1 
ATOM   3215 C  CG  . ASN B 1 111 ? 6.75267  1.86226   -105.44356 1.000 77.93670  ? 69  ASN B CG  1 
ATOM   3216 O  OD1 . ASN B 1 111 ? 6.10950  2.52614   -106.25346 1.000 78.78820  ? 69  ASN B OD1 1 
ATOM   3217 N  ND2 . ASN B 1 111 ? 8.08564  1.94529   -105.33222 1.000 87.84992  ? 69  ASN B ND2 1 
ATOM   3218 N  N   . VAL B 1 112 ? 5.86624  -2.00349  -103.07897 1.000 55.40248  ? 70  VAL B N   1 
ATOM   3219 C  CA  . VAL B 1 112 ? 5.19147  -2.89728  -102.14387 1.000 54.99884  ? 70  VAL B CA  1 
ATOM   3220 C  C   . VAL B 1 112 ? 6.13517  -3.33648  -101.02526 1.000 57.92030  ? 70  VAL B C   1 
ATOM   3221 O  O   . VAL B 1 112 ? 5.78484  -3.27139  -99.84217  1.000 57.92888  ? 70  VAL B O   1 
ATOM   3222 C  CB  . VAL B 1 112 ? 4.60534  -4.10149  -102.89944 1.000 65.90740  ? 70  VAL B CB  1 
ATOM   3223 C  CG1 . VAL B 1 112 ? 4.12688  -5.17571  -101.91323 1.000 61.72450  ? 70  VAL B CG1 1 
ATOM   3224 C  CG2 . VAL B 1 112 ? 3.46134  -3.63184  -103.79777 1.000 60.15101  ? 70  VAL B CG2 1 
ATOM   3225 N  N   . SER B 1 113 ? 7.34146  -3.79933  -101.38070 1.000 67.98521  ? 71  SER B N   1 
ATOM   3226 C  CA  . SER B 1 113 ? 8.33445  -4.17438  -100.37172 1.000 62.89414  ? 71  SER B CA  1 
ATOM   3227 C  C   . SER B 1 113 ? 8.60741  -3.02660  -99.40232  1.000 62.78089  ? 71  SER B C   1 
ATOM   3228 O  O   . SER B 1 113 ? 8.68850  -3.23397  -98.18399  1.000 59.08114  ? 71  SER B O   1 
ATOM   3229 C  CB  . SER B 1 113 ? 9.63035  -4.60736  -101.05828 1.000 49.87658  ? 71  SER B CB  1 
ATOM   3230 O  OG  . SER B 1 113 ? 9.37374  -5.63437  -102.00103 1.000 75.85549  ? 71  SER B OG  1 
ATOM   3231 N  N   . THR B 1 114 ? 8.74613  -1.80784  -99.93109  1.000 49.10780  ? 72  THR B N   1 
ATOM   3232 C  CA  . THR B 1 114 ? 8.88852  -0.62562  -99.08844  1.000 52.42957  ? 72  THR B CA  1 
ATOM   3233 C  C   . THR B 1 114 ? 7.70110  -0.47087  -98.14031  1.000 55.81060  ? 72  THR B C   1 
ATOM   3234 O  O   . THR B 1 114 ? 7.88000  -0.25947  -96.93621  1.000 57.01416  ? 72  THR B O   1 
ATOM   3235 C  CB  . THR B 1 114 ? 9.04233  0.61204   -99.97677  1.000 59.38454  ? 72  THR B CB  1 
ATOM   3236 O  OG1 . THR B 1 114 ? 10.16438 0.43082   -100.84705 1.000 62.09034  ? 72  THR B OG1 1 
ATOM   3237 C  CG2 . THR B 1 114 ? 9.23035  1.90063   -99.14767  1.000 53.52238  ? 72  THR B CG2 1 
ATOM   3238 N  N   . ILE B 1 115 ? 6.47567  -0.58080  -98.66594  1.000 56.52786  ? 73  ILE B N   1 
ATOM   3239 C  CA  . ILE B 1 115 ? 5.28004  -0.43105  -97.83148  1.000 59.28421  ? 73  ILE B CA  1 
ATOM   3240 C  C   . ILE B 1 115 ? 5.23991  -1.48765  -96.73202  1.000 58.09923  ? 73  ILE B C   1 
ATOM   3241 O  O   . ILE B 1 115 ? 4.89346  -1.19281  -95.57817  1.000 50.64568  ? 73  ILE B O   1 
ATOM   3242 C  CB  . ILE B 1 115 ? 4.01111  -0.47649  -98.70432  1.000 55.05708  ? 73  ILE B CB  1 
ATOM   3243 C  CG1 . ILE B 1 115 ? 3.86252  0.83368   -99.48440  1.000 47.62193  ? 73  ILE B CG1 1 
ATOM   3244 C  CG2 . ILE B 1 115 ? 2.78862  -0.81075  -97.85722  1.000 51.25303  ? 73  ILE B CG2 1 
ATOM   3245 C  CD1 . ILE B 1 115 ? 2.71551  0.84197   -100.44500 1.000 48.87370  ? 73  ILE B CD1 1 
ATOM   3246 N  N   . LEU B 1 116 ? 5.60258  -2.73023  -97.06792  1.000 61.43005  ? 74  LEU B N   1 
ATOM   3247 C  CA  . LEU B 1 116 ? 5.61631  -3.80170  -96.07710  1.000 58.95290  ? 74  LEU B CA  1 
ATOM   3248 C  C   . LEU B 1 116 ? 6.66962  -3.54522  -95.00292  1.000 57.92154  ? 74  LEU B C   1 
ATOM   3249 O  O   . LEU B 1 116 ? 6.40197  -3.71791  -93.80631  1.000 59.15236  ? 74  LEU B O   1 
ATOM   3250 C  CB  . LEU B 1 116 ? 5.85668  -5.13630  -96.77919  1.000 62.30716  ? 74  LEU B CB  1 
ATOM   3251 C  CG  . LEU B 1 116 ? 4.75303  -5.49849  -97.77833  1.000 60.40146  ? 74  LEU B CG  1 
ATOM   3252 C  CD1 . LEU B 1 116 ? 5.16419  -6.69777  -98.60698  1.000 58.67809  ? 74  LEU B CD1 1 
ATOM   3253 C  CD2 . LEU B 1 116 ? 3.40564  -5.73068  -97.08033  1.000 51.40243  ? 74  LEU B CD2 1 
ATOM   3254 N  N   . ALA B 1 117 ? 7.85884  -3.09072  -95.40984  1.000 57.78696  ? 75  ALA B N   1 
ATOM   3255 C  CA  . ALA B 1 117 ? 8.87030  -2.67228  -94.44064  1.000 62.51707  ? 75  ALA B CA  1 
ATOM   3256 C  C   . ALA B 1 117 ? 8.35957  -1.53561  -93.56219  1.000 65.81404  ? 75  ALA B C   1 
ATOM   3257 O  O   . ALA B 1 117 ? 8.55793  -1.55188  -92.34122  1.000 63.46112  ? 75  ALA B O   1 
ATOM   3258 C  CB  . ALA B 1 117 ? 10.14157 -2.23365  -95.16559  1.000 52.00679  ? 75  ALA B CB  1 
ATOM   3259 N  N   . GLY B 1 118 ? 7.68012  -0.54830  -94.16898  1.000 61.83952  ? 76  GLY B N   1 
ATOM   3260 C  CA  . GLY B 1 118 ? 7.17421  0.59203   -93.41754  1.000 57.02799  ? 76  GLY B CA  1 
ATOM   3261 C  C   . GLY B 1 118 ? 6.12103  0.22850   -92.39219  1.000 67.10333  ? 76  GLY B C   1 
ATOM   3262 O  O   . GLY B 1 118 ? 5.97167  0.92503   -91.38255  1.000 63.48613  ? 76  GLY B O   1 
ATOM   3263 N  N   . GLY B 1 119 ? 5.38297  -0.86500  -92.62752  1.000 69.84490  ? 77  GLY B N   1 
ATOM   3264 C  CA  . GLY B 1 119 ? 4.45020  -1.34779  -91.62110  1.000 60.36784  ? 77  GLY B CA  1 
ATOM   3265 C  C   . GLY B 1 119 ? 5.14022  -1.73093  -90.32519  1.000 66.07253  ? 77  GLY B C   1 
ATOM   3266 O  O   . GLY B 1 119 ? 4.68944  -1.35954  -89.23871  1.000 64.37639  ? 77  GLY B O   1 
ATOM   3267 N  N   . SER B 1 120 ? 6.25847  -2.45522  -90.41813  1.000 62.10954  ? 78  SER B N   1 
ATOM   3268 C  CA  . SER B 1 120 ? 7.04865  -2.71300  -89.22116  1.000 66.63595  ? 78  SER B CA  1 
ATOM   3269 C  C   . SER B 1 120 ? 7.73886  -1.45622  -88.69631  1.000 71.36851  ? 78  SER B C   1 
ATOM   3270 O  O   . SER B 1 120 ? 8.24547  -1.47858  -87.57027  1.000 81.62089  ? 78  SER B O   1 
ATOM   3271 C  CB  . SER B 1 120 ? 8.09310  -3.79356  -89.50656  1.000 68.74006  ? 78  SER B CB  1 
ATOM   3272 O  OG  . SER B 1 120 ? 7.72416  -4.54863  -90.64543  1.000 68.94436  ? 78  SER B OG  1 
ATOM   3273 N  N   . GLY B 1 121 ? 7.74605  -0.36126  -89.46566  1.000 68.36975  ? 79  GLY B N   1 
ATOM   3274 C  CA  . GLY B 1 121 ? 8.38080  0.88613   -89.07650  1.000 64.91782  ? 79  GLY B CA  1 
ATOM   3275 C  C   . GLY B 1 121 ? 9.64976  1.21547   -89.84742  1.000 70.77354  ? 79  GLY B C   1 
ATOM   3276 O  O   . GLY B 1 121 ? 10.20962 2.30869   -89.65122  1.000 75.06339  ? 79  GLY B O   1 
ATOM   3277 N  N   . THR B 1 122 ? 10.12109 0.30666   -90.71110  1.000 64.77895  ? 80  THR B N   1 
ATOM   3278 C  CA  . THR B 1 122 ? 11.39125 0.47741   -91.41485  1.000 62.51302  ? 80  THR B CA  1 
ATOM   3279 C  C   . THR B 1 122 ? 11.28548 1.54791   -92.50048  1.000 58.88703  ? 80  THR B C   1 
ATOM   3280 O  O   . THR B 1 122 ? 10.39114 1.50085   -93.35318  1.000 61.70715  ? 80  THR B O   1 
ATOM   3281 C  CB  . THR B 1 122 ? 11.81322 -0.85271  -92.04955  1.000 57.96053  ? 80  THR B CB  1 
ATOM   3282 O  OG1 . THR B 1 122 ? 11.86773 -1.88085  -91.05013  1.000 64.66104  ? 80  THR B OG1 1 
ATOM   3283 C  CG2 . THR B 1 122 ? 13.15661 -0.72643  -92.72002  1.000 48.69740  ? 80  THR B CG2 1 
ATOM   3284 N  N   . GLY B 1 123 ? 12.22518 2.49923   -92.49069  1.000 46.26426  ? 81  GLY B N   1 
ATOM   3285 C  CA  . GLY B 1 123 ? 12.26739 3.51599   -93.52387  1.000 45.68007  ? 81  GLY B CA  1 
ATOM   3286 C  C   . GLY B 1 123 ? 12.87181 2.99118   -94.82199  1.000 46.24380  ? 81  GLY B C   1 
ATOM   3287 O  O   . GLY B 1 123 ? 13.42157 1.89420   -94.89618  1.000 48.78402  ? 81  GLY B O   1 
ATOM   3288 N  N   . SER B 1 124 ? 12.76698 3.80511   -95.87327  1.000 57.82811  ? 82  SER B N   1 
ATOM   3289 C  CA  . SER B 1 124 ? 13.24833 3.41235   -97.18978  1.000 55.31520  ? 82  SER B CA  1 
ATOM   3290 C  C   . SER B 1 124 ? 14.47363 4.18595   -97.64061  1.000 55.32594  ? 82  SER B C   1 
ATOM   3291 O  O   . SER B 1 124 ? 15.22924 3.68211   -98.48191  1.000 57.43822  ? 82  SER B O   1 
ATOM   3292 C  CB  . SER B 1 124 ? 12.14537 3.58702   -98.24214  1.000 60.18737  ? 82  SER B CB  1 
ATOM   3293 O  OG  . SER B 1 124 ? 11.09578 4.41068   -97.75038  1.000 59.64349  ? 82  SER B OG  1 
ATOM   3294 N  N   . VAL B 1 125 ? 14.69962 5.37741   -97.10028  1.000 46.74964  ? 83  VAL B N   1 
ATOM   3295 C  CA  . VAL B 1 125 ? 15.82071 6.21334   -97.51421  1.000 49.97276  ? 83  VAL B CA  1 
ATOM   3296 C  C   . VAL B 1 125 ? 16.62248 6.62717   -96.28651  1.000 31.33838  ? 83  VAL B C   1 
ATOM   3297 O  O   . VAL B 1 125 ? 16.04712 6.99432   -95.25765  1.000 43.39847  ? 83  VAL B O   1 
ATOM   3298 C  CB  . VAL B 1 125 ? 15.34170 7.44971   -98.28753  1.000 40.21950  ? 83  VAL B CB  1 
ATOM   3299 C  CG1 . VAL B 1 125 ? 14.37657 8.25646   -97.43100  1.000 37.75393  ? 83  VAL B CG1 1 
ATOM   3300 C  CG2 . VAL B 1 125 ? 16.54564 8.25448   -98.73055  1.000 40.42306  ? 83  VAL B CG2 1 
ATOM   3301 N  N   . THR B 1 126 ? 17.94293 6.53467   -96.37549  1.000 39.29613  ? 84  THR B N   1 
ATOM   3302 C  CA  . THR B 1 126 ? 18.77469 6.96081   -95.26128  1.000 28.15627  ? 84  THR B CA  1 
ATOM   3303 C  C   . THR B 1 126 ? 18.77500 8.48950   -95.09553  1.000 26.96824  ? 84  THR B C   1 
ATOM   3304 O  O   . THR B 1 126 ? 18.56576 9.24546   -96.04216  1.000 24.34884  ? 84  THR B O   1 
ATOM   3305 C  CB  . THR B 1 126 ? 20.18990 6.42674   -95.44603  1.000 32.81357  ? 84  THR B CB  1 
ATOM   3306 O  OG1 . THR B 1 126 ? 20.81810 7.08916   -96.54358  1.000 37.53877  ? 84  THR B OG1 1 
ATOM   3307 C  CG2 . THR B 1 126 ? 20.15462 4.94656   -95.75090  1.000 39.28059  ? 84  THR B CG2 1 
ATOM   3308 N  N   . LEU B 1 127 ? 18.96904 8.93955   -93.85730  1.000 24.14524  ? 85  LEU B N   1 
ATOM   3309 C  CA  . LEU B 1 127 ? 19.23887 10.34855  -93.59268  1.000 24.63673  ? 85  LEU B CA  1 
ATOM   3310 C  C   . LEU B 1 127 ? 20.51744 10.82199  -94.30092  1.000 23.35655  ? 85  LEU B C   1 
ATOM   3311 O  O   . LEU B 1 127 ? 21.60534 10.28440  -94.06613  1.000 25.29045  ? 85  LEU B O   1 
ATOM   3312 C  CB  . LEU B 1 127 ? 19.37843 10.54113  -92.08686  1.000 24.31190  ? 85  LEU B CB  1 
ATOM   3313 C  CG  . LEU B 1 127 ? 18.22307 9.99337   -91.25465  1.000 20.49629  ? 85  LEU B CG  1 
ATOM   3314 C  CD1 . LEU B 1 127 ? 18.56057 10.15302  -89.79044  1.000 18.09625  ? 85  LEU B CD1 1 
ATOM   3315 C  CD2 . LEU B 1 127 ? 16.95630 10.73457  -91.59229  1.000 20.97953  ? 85  LEU B CD2 1 
ATOM   3316 N  N   . ALA B 1 128 ? 20.39789 11.88563  -95.10847  1.000 27.42666  ? 86  ALA B N   1 
ATOM   3317 C  CA  . ALA B 1 128 ? 21.55358 12.43251  -95.82884  1.000 29.96126  ? 86  ALA B CA  1 
ATOM   3318 C  C   . ALA B 1 128 ? 22.61531 12.98041  -94.87666  1.000 26.79472  ? 86  ALA B C   1 
ATOM   3319 O  O   . ALA B 1 128 ? 23.81139 12.69824  -95.03063  1.000 32.75250  ? 86  ALA B O   1 
ATOM   3320 C  CB  . ALA B 1 128 ? 21.11176 13.53137  -96.79060  1.000 28.68182  ? 86  ALA B CB  1 
ATOM   3321 N  N   . GLY B 1 129 ? 22.20882 13.77183  -93.89269  1.000 26.86689  ? 87  GLY B N   1 
ATOM   3322 C  CA  . GLY B 1 129 ? 23.19403 14.28293  -92.95633  1.000 26.14508  ? 87  GLY B CA  1 
ATOM   3323 C  C   . GLY B 1 129 ? 24.17357 15.28917  -93.51964  1.000 26.28419  ? 87  GLY B C   1 
ATOM   3324 O  O   . GLY B 1 129 ? 25.17839 15.58586  -92.86450  1.000 27.63391  ? 87  GLY B O   1 
ATOM   3325 N  N   . ASN B 1 130 ? 23.90942 15.84788  -94.69502  1.000 21.79830  ? 88  ASN B N   1 
ATOM   3326 C  CA  . ASN B 1 130 ? 24.84545 16.77505  -95.31041  1.000 30.45290  ? 88  ASN B CA  1 
ATOM   3327 C  C   . ASN B 1 130 ? 24.50083 18.24931  -95.04617  1.000 31.59063  ? 88  ASN B C   1 
ATOM   3328 O  O   . ASN B 1 130 ? 25.22893 19.13363  -95.48956  1.000 29.27974  ? 88  ASN B O   1 
ATOM   3329 C  CB  . ASN B 1 130 ? 24.94188 16.50658  -96.82699  1.000 31.24242  ? 88  ASN B CB  1 
ATOM   3330 C  CG  . ASN B 1 130 ? 23.60882 16.64249  -97.54806  1.000 38.65809  ? 88  ASN B CG  1 
ATOM   3331 O  OD1 . ASN B 1 130 ? 22.58084 16.89678  -96.92999  1.000 40.68636  ? 88  ASN B OD1 1 
ATOM   3332 N  ND2 . ASN B 1 130 ? 23.62532 16.47647  -98.87772  1.000 58.91155  ? 88  ASN B ND2 1 
ATOM   3333 N  N   . SER B 1 131 ? 23.41994 18.54327  -94.34259  1.000 27.16739  ? 89  SER B N   1 
ATOM   3334 C  CA  . SER B 1 131 ? 23.06343 19.93581  -94.13169  1.000 29.08401  ? 89  SER B CA  1 
ATOM   3335 C  C   . SER B 1 131 ? 23.75790 20.51984  -92.89345  1.000 29.89601  ? 89  SER B C   1 
ATOM   3336 O  O   . SER B 1 131 ? 24.20543 19.81022  -91.98121  1.000 22.40224  ? 89  SER B O   1 
ATOM   3337 C  CB  . SER B 1 131 ? 21.53157 20.08095  -94.04788  1.000 29.98528  ? 89  SER B CB  1 
ATOM   3338 O  OG  . SER B 1 131 ? 21.00760 19.47296  -92.88518  1.000 26.41435  ? 89  SER B OG  1 
ATOM   3339 N  N   . SER B 1 132 ? 23.85587 21.84291  -92.88078  1.000 21.08423  ? 90  SER B N   1 
ATOM   3340 C  CA  . SER B 1 132 ? 24.48692 22.55818  -91.78649  1.000 23.47558  ? 90  SER B CA  1 
ATOM   3341 C  C   . SER B 1 132 ? 23.47002 22.85400  -90.69973  1.000 22.46026  ? 90  SER B C   1 
ATOM   3342 O  O   . SER B 1 132 ? 22.26144 22.85341  -90.93670  1.000 25.13236  ? 90  SER B O   1 
ATOM   3343 C  CB  . SER B 1 132 ? 25.10010 23.87317  -92.28990  1.000 26.27404  ? 90  SER B CB  1 
ATOM   3344 O  OG  . SER B 1 132 ? 26.06699 23.60647  -93.29215  1.000 29.97261  ? 90  SER B OG  1 
ATOM   3345 N  N   . LEU B 1 133 ? 23.97095 23.14362  -89.50246  1.000 19.44326  ? 91  LEU B N   1 
ATOM   3346 C  CA  . LEU B 1 133 ? 23.07131 23.46789  -88.41027  1.000 21.00836  ? 91  LEU B CA  1 
ATOM   3347 C  C   . LEU B 1 133 ? 22.25638 24.71679  -88.74800  1.000 25.35145  ? 91  LEU B C   1 
ATOM   3348 O  O   . LEU B 1 133 ? 22.78120 25.69265  -89.29630  1.000 26.17804  ? 91  LEU B O   1 
ATOM   3349 C  CB  . LEU B 1 133 ? 23.84808 23.68519  -87.11927  1.000 18.90869  ? 91  LEU B CB  1 
ATOM   3350 C  CG  . LEU B 1 133 ? 24.55201 22.53700  -86.42580  1.000 22.84982  ? 91  LEU B CG  1 
ATOM   3351 C  CD1 . LEU B 1 133 ? 25.23934 23.02157  -85.14944  1.000 16.42228  ? 91  LEU B CD1 1 
ATOM   3352 C  CD2 . LEU B 1 133 ? 23.50683 21.52275  -86.08964  1.000 19.94824  ? 91  LEU B CD2 1 
ATOM   3353 N  N   . CYS B 1 134 ? 20.97094 24.66718  -88.40633  1.000 20.39634  ? 92  CYS B N   1 
ATOM   3354 C  CA  . CYS B 1 134 ? 20.07019 25.79715  -88.57997  1.000 26.04249  ? 92  CYS B CA  1 
ATOM   3355 C  C   . CYS B 1 134 ? 20.57460 27.02747  -87.82538  1.000 26.87391  ? 92  CYS B C   1 
ATOM   3356 O  O   . CYS B 1 134 ? 21.04814 26.91120  -86.68444  1.000 22.25301  ? 92  CYS B O   1 
ATOM   3357 C  CB  . CYS B 1 134 ? 18.67112 25.44432  -88.06940  1.000 30.49441  ? 92  CYS B CB  1 
ATOM   3358 S  SG  . CYS B 1 134 ? 17.83164 24.12371  -89.01688  1.000 37.80545  ? 92  CYS B SG  1 
ATOM   3359 N  N   . PRO B 1 135 ? 20.44688 28.22006  -88.40627  1.000 28.69176  ? 93  PRO B N   1 
ATOM   3360 C  CA  . PRO B 1 135 ? 20.59992 29.44697  -87.60807  1.000 22.53028  ? 93  PRO B CA  1 
ATOM   3361 C  C   . PRO B 1 135 ? 19.53090 29.49802  -86.52829  1.000 24.40974  ? 93  PRO B C   1 
ATOM   3362 O  O   . PRO B 1 135 ? 18.34676 29.27291  -86.79220  1.000 30.41187  ? 93  PRO B O   1 
ATOM   3363 C  CB  . PRO B 1 135 ? 20.42195 30.56946  -88.63941  1.000 23.52196  ? 93  PRO B CB  1 
ATOM   3364 C  CG  . PRO B 1 135 ? 20.61610 29.90111  -89.99184  1.000 32.07791  ? 93  PRO B CG  1 
ATOM   3365 C  CD  . PRO B 1 135 ? 20.09156 28.50564  -89.80887  1.000 29.12133  ? 93  PRO B CD  1 
ATOM   3366 N  N   . ILE B 1 136 ? 19.95532 29.76560  -85.29583  1.000 20.16371  ? 94  ILE B N   1 
ATOM   3367 C  CA  . ILE B 1 136 ? 19.03831 29.84647  -84.16573  1.000 27.10360  ? 94  ILE B CA  1 
ATOM   3368 C  C   . ILE B 1 136 ? 19.39388 31.06661  -83.32486  1.000 35.04376  ? 94  ILE B C   1 
ATOM   3369 O  O   . ILE B 1 136 ? 20.51682 31.58495  -83.37292  1.000 29.36219  ? 94  ILE B O   1 
ATOM   3370 C  CB  . ILE B 1 136 ? 19.07112 28.60973  -83.24395  1.000 28.98692  ? 94  ILE B CB  1 
ATOM   3371 C  CG1 . ILE B 1 136 ? 20.44426 28.55817  -82.55629  1.000 24.14250  ? 94  ILE B CG1 1 
ATOM   3372 C  CG2 . ILE B 1 136 ? 18.65789 27.31669  -83.99816  1.000 22.14472  ? 94  ILE B CG2 1 
ATOM   3373 C  CD1 . ILE B 1 136 ? 20.61688 27.38472  -81.59080  1.000 24.46851  ? 94  ILE B CD1 1 
ATOM   3374 N  N   . SER B 1 137 ? 18.41426 31.51088  -82.51822  1.000 23.13567  ? 95  SER B N   1 
ATOM   3375 C  CA  . SER B 1 137 ? 18.64630 32.58333  -81.56113  1.000 18.15466  ? 95  SER B CA  1 
ATOM   3376 C  C   . SER B 1 137 ? 18.42074 32.15770  -80.11885  1.000 23.21791  ? 95  SER B C   1 
ATOM   3377 O  O   . SER B 1 137 ? 18.86871 32.85986  -79.20598  1.000 15.06390  ? 95  SER B O   1 
ATOM   3378 C  CB  . SER B 1 137 ? 17.74684 33.78770  -81.89249  1.000 21.13229  ? 95  SER B CB  1 
ATOM   3379 O  OG  . SER B 1 137 ? 16.38486 33.40497  -81.76957  1.000 32.20667  ? 95  SER B OG  1 
ATOM   3380 N  N   . GLY B 1 138 ? 17.77828 31.01873  -79.88586  1.000 20.18505  ? 96  GLY B N   1 
ATOM   3381 C  CA  . GLY B 1 138 ? 17.47448 30.60424  -78.52870  1.000 17.95209  ? 96  GLY B CA  1 
ATOM   3382 C  C   . GLY B 1 138 ? 16.84440 29.22601  -78.54670  1.000 18.67916  ? 96  GLY B C   1 
ATOM   3383 O  O   . GLY B 1 138 ? 16.75898 28.58227  -79.59102  1.000 17.55816  ? 96  GLY B O   1 
ATOM   3384 N  N   . TRP B 1 139 ? 16.38540 28.78609  -77.37900  1.000 18.65358  ? 97  TRP B N   1 
ATOM   3385 C  CA  . TRP B 1 139 ? 15.96619 27.40448  -77.17849  1.000 21.68741  ? 97  TRP B CA  1 
ATOM   3386 C  C   . TRP B 1 139 ? 14.52226 27.37219  -76.69270  1.000 22.81495  ? 97  TRP B C   1 
ATOM   3387 O  O   . TRP B 1 139 ? 14.19537 28.02687  -75.70008  1.000 20.72019  ? 97  TRP B O   1 
ATOM   3388 C  CB  . TRP B 1 139 ? 16.92393 26.72420  -76.20018  1.000 15.27770  ? 97  TRP B CB  1 
ATOM   3389 C  CG  . TRP B 1 139 ? 18.31785 26.84528  -76.71063  1.000 20.82283  ? 97  TRP B CG  1 
ATOM   3390 C  CD1 . TRP B 1 139 ? 19.19755 27.88989  -76.49185  1.000 20.36832  ? 97  TRP B CD1 1 
ATOM   3391 C  CD2 . TRP B 1 139 ? 18.98786 25.93739  -77.59312  1.000 17.62094  ? 97  TRP B CD2 1 
ATOM   3392 N  NE1 . TRP B 1 139 ? 20.38198 27.66455  -77.16275  1.000 20.22547  ? 97  TRP B NE1 1 
ATOM   3393 C  CE2 . TRP B 1 139 ? 20.27461 26.47982  -77.85698  1.000 20.59533  ? 97  TRP B CE2 1 
ATOM   3394 C  CE3 . TRP B 1 139 ? 18.62854 24.72304  -78.18900  1.000 19.23961  ? 97  TRP B CE3 1 
ATOM   3395 C  CZ2 . TRP B 1 139 ? 21.19686 25.83966  -78.68511  1.000 19.10009  ? 97  TRP B CZ2 1 
ATOM   3396 C  CZ3 . TRP B 1 139 ? 19.53176 24.09262  -79.01778  1.000 17.54836  ? 97  TRP B CZ3 1 
ATOM   3397 C  CH2 . TRP B 1 139 ? 20.81214 24.64677  -79.25434  1.000 24.90404  ? 97  TRP B CH2 1 
ATOM   3398 N  N   . ALA B 1 140 ? 13.67377 26.61451  -77.40787  1.000 12.36394  ? 98  ALA B N   1 
ATOM   3399 C  CA  . ALA B 1 140 ? 12.25917 26.44200  -77.10848  1.000 15.57427  ? 98  ALA B CA  1 
ATOM   3400 C  C   . ALA B 1 140 ? 12.07307 25.09628  -76.42976  1.000 20.20908  ? 98  ALA B C   1 
ATOM   3401 O  O   . ALA B 1 140 ? 12.57831 24.07823  -76.92398  1.000 19.77997  ? 98  ALA B O   1 
ATOM   3402 C  CB  . ALA B 1 140 ? 11.42868 26.48416  -78.39731  1.000 12.83446  ? 98  ALA B CB  1 
ATOM   3403 N  N   . ILE B 1 141 ? 11.35773 25.07791  -75.30628  1.000 17.25581  ? 99  ILE B N   1 
ATOM   3404 C  CA  . ILE B 1 141 ? 11.22303 23.81484  -74.58581  1.000 21.58930  ? 99  ILE B CA  1 
ATOM   3405 C  C   . ILE B 1 141 ? 10.43883 22.81850  -75.42683  1.000 20.41421  ? 99  ILE B C   1 
ATOM   3406 O  O   . ILE B 1 141 ? 9.38630  23.13890  -76.00305  1.000 14.93803  ? 99  ILE B O   1 
ATOM   3407 C  CB  . ILE B 1 141 ? 10.59340 24.00432  -73.19951  1.000 21.56247  ? 99  ILE B CB  1 
ATOM   3408 C  CG1 . ILE B 1 141 ? 10.80031 22.69721  -72.39898  1.000 16.86125  ? 99  ILE B CG1 1 
ATOM   3409 C  CG2 . ILE B 1 141 ? 9.09570  24.41242  -73.30886  1.000 17.61625  ? 99  ILE B CG2 1 
ATOM   3410 C  CD1 . ILE B 1 141 ? 10.87027 22.93260  -70.92927  1.000 15.13684  ? 99  ILE B CD1 1 
ATOM   3411 N  N   . TYR B 1 142 ? 10.98328 21.60799  -75.53000  1.000 18.29425  ? 100 TYR B N   1 
ATOM   3412 C  CA  . TYR B 1 142 ? 10.45046 20.52410  -76.32918  1.000 21.80018  ? 100 TYR B CA  1 
ATOM   3413 C  C   . TYR B 1 142 ? 9.77389  19.49189  -75.43936  1.000 25.50884  ? 100 TYR B C   1 
ATOM   3414 O  O   . TYR B 1 142 ? 8.62947  19.12888  -75.68860  1.000 18.65641  ? 100 TYR B O   1 
ATOM   3415 C  CB  . TYR B 1 142 ? 11.56530 19.86775  -77.16015  1.000 18.21750  ? 100 TYR B CB  1 
ATOM   3416 C  CG  . TYR B 1 142 ? 11.13178 18.77845  -78.15109  1.000 21.90566  ? 100 TYR B CG  1 
ATOM   3417 C  CD1 . TYR B 1 142 ? 10.29710 19.07083  -79.23156  1.000 23.26497  ? 100 TYR B CD1 1 
ATOM   3418 C  CD2 . TYR B 1 142 ? 11.61560 17.46002  -78.04389  1.000 22.16641  ? 100 TYR B CD2 1 
ATOM   3419 C  CE1 . TYR B 1 142 ? 9.90259  18.06627  -80.14478  1.000 23.88907  ? 100 TYR B CE1 1 
ATOM   3420 C  CE2 . TYR B 1 142 ? 11.21765 16.46123  -78.94904  1.000 25.75627  ? 100 TYR B CE2 1 
ATOM   3421 C  CZ  . TYR B 1 142 ? 10.37410 16.78084  -80.00432  1.000 26.52500  ? 100 TYR B CZ  1 
ATOM   3422 O  OH  . TYR B 1 142 ? 9.99535  15.80844  -80.91938  1.000 33.08988  ? 100 TYR B OH  1 
ATOM   3423 N  N   . SER B 1 143 ? 10.41404 19.05994  -74.35245  1.000 15.86380  ? 101 SER B N   1 
ATOM   3424 C  CA  . SER B 1 143 ? 9.73859  18.04068  -73.56238  1.000 22.85255  ? 101 SER B CA  1 
ATOM   3425 C  C   . SER B 1 143 ? 10.03296 18.23085  -72.08882  1.000 13.41002  ? 101 SER B C   1 
ATOM   3426 O  O   . SER B 1 143 ? 10.98110 18.90762  -71.71319  1.000 21.80602  ? 101 SER B O   1 
ATOM   3427 C  CB  . SER B 1 143 ? 10.15347 16.62823  -73.98737  1.000 16.59431  ? 101 SER B CB  1 
ATOM   3428 O  OG  . SER B 1 143 ? 11.41152 16.25452  -73.42031  1.000 19.73186  ? 101 SER B OG  1 
ATOM   3429 N  N   . LYS B 1 144 ? 9.20419  17.59420  -71.25990  1.000 13.95365  ? 102 LYS B N   1 
ATOM   3430 C  CA  . LYS B 1 144 ? 9.49043  17.35501  -69.85231  1.000 14.39877  ? 102 LYS B CA  1 
ATOM   3431 C  C   . LYS B 1 144 ? 8.71068  16.11426  -69.45353  1.000 22.88835  ? 102 LYS B C   1 
ATOM   3432 O  O   . LYS B 1 144 ? 7.51844  15.99693  -69.79099  1.000 14.98069  ? 102 LYS B O   1 
ATOM   3433 C  CB  . LYS B 1 144 ? 9.09223  18.54192  -68.96424  1.000 19.48519  ? 102 LYS B CB  1 
ATOM   3434 C  CG  . LYS B 1 144 ? 9.44984  18.36294  -67.47663  1.000 15.61362  ? 102 LYS B CG  1 
ATOM   3435 C  CD  . LYS B 1 144 ? 8.92521  19.53671  -66.61289  1.000 17.71123  ? 102 LYS B CD  1 
ATOM   3436 C  CE  . LYS B 1 144 ? 9.76862  19.71756  -65.33146  1.000 17.61509  ? 102 LYS B CE  1 
ATOM   3437 N  NZ  . LYS B 1 144 ? 9.88727  18.46381  -64.49415  1.000 23.22096  ? 102 LYS B NZ  1 
ATOM   3438 N  N   . ASP B 1 145 ? 9.35224  15.18581  -68.73714  1.000 15.67690  ? 103 ASP B N   1 
ATOM   3439 C  CA  . ASP B 1 145 ? 8.63908  13.94415  -68.45287  1.000 18.27456  ? 103 ASP B CA  1 
ATOM   3440 C  C   . ASP B 1 145 ? 8.17901  13.79449  -67.00843  1.000 20.48159  ? 103 ASP B C   1 
ATOM   3441 O  O   . ASP B 1 145 ? 7.39081  12.89466  -66.74008  1.000 19.96306  ? 103 ASP B O   1 
ATOM   3442 C  CB  . ASP B 1 145 ? 9.48146  12.70894  -68.86119  1.000 19.16968  ? 103 ASP B CB  1 
ATOM   3443 C  CG  . ASP B 1 145 ? 10.83435 12.61940  -68.14146  1.000 26.11034  ? 103 ASP B CG  1 
ATOM   3444 O  OD1 . ASP B 1 145 ? 11.03364 13.20907  -67.05411  1.000 22.05493  ? 103 ASP B OD1 1 
ATOM   3445 O  OD2 . ASP B 1 145 ? 11.70894 11.90984  -68.68183  1.000 29.01175  ? 103 ASP B OD2 1 
ATOM   3446 N  N   . ASN B 1 146 ? 8.65810  14.61884  -66.06628  1.000 16.21022  ? 104 ASN B N   1 
ATOM   3447 C  CA  . ASN B 1 146 ? 8.19933  14.52069  -64.68172  1.000 15.19709  ? 104 ASN B CA  1 
ATOM   3448 C  C   . ASN B 1 146 ? 8.34255  13.07529  -64.15178  1.000 20.25007  ? 104 ASN B C   1 
ATOM   3449 O  O   . ASN B 1 146 ? 7.57792  12.62369  -63.30166  1.000 14.68484  ? 104 ASN B O   1 
ATOM   3450 C  CB  . ASN B 1 146 ? 6.74430  15.03312  -64.55072  1.000 16.63176  ? 104 ASN B CB  1 
ATOM   3451 C  CG  . ASN B 1 146 ? 6.63891  16.57813  -64.70963  1.000 18.51584  ? 104 ASN B CG  1 
ATOM   3452 O  OD1 . ASN B 1 146 ? 7.41720  17.31811  -64.11491  1.000 16.66255  ? 104 ASN B OD1 1 
ATOM   3453 N  ND2 . ASN B 1 146 ? 5.71034  17.04244  -65.53752  1.000 16.87297  ? 104 ASN B ND2 1 
ATOM   3454 N  N   . GLY B 1 147 ? 9.36608  12.34634  -64.60822  1.000 18.55576  ? 105 GLY B N   1 
ATOM   3455 C  CA  . GLY B 1 147 ? 9.42957  10.91853  -64.30447  1.000 17.04217  ? 105 GLY B CA  1 
ATOM   3456 C  C   . GLY B 1 147 ? 9.39730  10.63916  -62.81583  1.000 17.56990  ? 105 GLY B C   1 
ATOM   3457 O  O   . GLY B 1 147 ? 8.64425  9.78159   -62.35137  1.000 18.61424  ? 105 GLY B O   1 
ATOM   3458 N  N   . ILE B 1 148 ? 10.14644 11.41702  -62.03796  1.000 18.80710  ? 106 ILE B N   1 
ATOM   3459 C  CA  . ILE B 1 148 ? 10.31266 11.10936  -60.61919  1.000 16.98198  ? 106 ILE B CA  1 
ATOM   3460 C  C   . ILE B 1 148 ? 9.07819  11.52091  -59.81043  1.000 15.91308  ? 106 ILE B C   1 
ATOM   3461 O  O   . ILE B 1 148 ? 8.67515  10.79940  -58.88712  1.000 15.60540  ? 106 ILE B O   1 
ATOM   3462 C  CB  . ILE B 1 148 ? 11.62277 11.74861  -60.10962  1.000 16.80273  ? 106 ILE B CB  1 
ATOM   3463 C  CG1 . ILE B 1 148 ? 12.80906 11.04061  -60.79491  1.000 16.64697  ? 106 ILE B CG1 1 
ATOM   3464 C  CG2 . ILE B 1 148 ? 11.76676 11.57790  -58.61237  1.000 17.59777  ? 106 ILE B CG2 1 
ATOM   3465 C  CD1 . ILE B 1 148 ? 14.14153 11.60153  -60.46649  1.000 14.56348  ? 106 ILE B CD1 1 
ATOM   3466 N  N   . ARG B 1 149 ? 8.44320  12.67176  -60.14536  1.000 17.19748  ? 107 ARG B N   1 
ATOM   3467 C  CA  . ARG B 1 149 ? 7.14845  13.02590  -59.54731  1.000 22.72491  ? 107 ARG B CA  1 
ATOM   3468 C  C   . ARG B 1 149 ? 6.11700  11.92448  -59.79755  1.000 13.06722  ? 107 ARG B C   1 
ATOM   3469 O  O   . ARG B 1 149 ? 5.46522  11.44334  -58.86810  1.000 17.60268  ? 107 ARG B O   1 
ATOM   3470 C  CB  . ARG B 1 149 ? 6.64289  14.36899  -60.11245  1.000 12.88531  ? 107 ARG B CB  1 
ATOM   3471 C  CG  . ARG B 1 149 ? 7.45534  15.60089  -59.60997  1.000 15.55256  ? 107 ARG B CG  1 
ATOM   3472 C  CD  . ARG B 1 149 ? 7.11967  16.81767  -60.42990  1.000 19.15876  ? 107 ARG B CD  1 
ATOM   3473 N  NE  . ARG B 1 149 ? 5.69723  17.11989  -60.36680  1.000 19.40861  ? 107 ARG B NE  1 
ATOM   3474 C  CZ  . ARG B 1 149 ? 5.11982  17.81323  -59.39130  1.000 22.53277  ? 107 ARG B CZ  1 
ATOM   3475 N  NH1 . ARG B 1 149 ? 5.79382  18.19854  -58.32369  1.000 15.00389  ? 107 ARG B NH1 1 
ATOM   3476 N  NH2 . ARG B 1 149 ? 3.82564  18.10761  -59.48298  1.000 17.23797  ? 107 ARG B NH2 1 
ATOM   3477 N  N   . ILE B 1 150 ? 6.02759  11.45519  -61.04118  1.000 15.58688  ? 108 ILE B N   1 
ATOM   3478 C  CA  . ILE B 1 150 ? 5.04350  10.43237  -61.39176  1.000 19.68199  ? 108 ILE B CA  1 
ATOM   3479 C  C   . ILE B 1 150 ? 5.33829  9.12773   -60.65035  1.000 22.36305  ? 108 ILE B C   1 
ATOM   3480 O  O   . ILE B 1 150 ? 4.41991  8.46379   -60.13564  1.000 17.90224  ? 108 ILE B O   1 
ATOM   3481 C  CB  . ILE B 1 150 ? 5.01177  10.26429  -62.92865  1.000 19.75527  ? 108 ILE B CB  1 
ATOM   3482 C  CG1 . ILE B 1 150 ? 4.44964  11.56194  -63.56728  1.000 17.63806  ? 108 ILE B CG1 1 
ATOM   3483 C  CG2 . ILE B 1 150 ? 4.22188  9.00108   -63.35288  1.000 12.08690  ? 108 ILE B CG2 1 
ATOM   3484 C  CD1 . ILE B 1 150 ? 4.57608  11.67784  -65.07993  1.000 14.44603  ? 108 ILE B CD1 1 
ATOM   3485 N  N   . GLY B 1 151 ? 6.63106  8.77511   -60.51478  1.000 18.72600  ? 109 GLY B N   1 
ATOM   3486 C  CA  . GLY B 1 151 ? 7.05831  7.51765   -59.89830  1.000 17.26705  ? 109 GLY B CA  1 
ATOM   3487 C  C   . GLY B 1 151 ? 6.96713  7.45887   -58.38939  1.000 21.98149  ? 109 GLY B C   1 
ATOM   3488 O  O   . GLY B 1 151 ? 7.20710  6.39472   -57.80534  1.000 22.71903  ? 109 GLY B O   1 
ATOM   3489 N  N   . SER B 1 152 ? 6.68051  8.58756   -57.73780  1.000 17.94011  ? 110 SER B N   1 
ATOM   3490 C  CA  . SER B 1 152 ? 6.31420  8.55259   -56.32625  1.000 13.63645  ? 110 SER B CA  1 
ATOM   3491 C  C   . SER B 1 152 ? 5.12575  7.60409   -56.09424  1.000 21.09800  ? 110 SER B C   1 
ATOM   3492 O  O   . SER B 1 152 ? 4.99115  7.02058   -55.01475  1.000 21.85210  ? 110 SER B O   1 
ATOM   3493 C  CB  . SER B 1 152 ? 5.97593  9.96983   -55.86949  1.000 19.48473  ? 110 SER B CB  1 
ATOM   3494 O  OG  . SER B 1 152 ? 5.59797  10.04830  -54.50092  1.000 24.25288  ? 110 SER B OG  1 
ATOM   3495 N  N   . LYS B 1 153 ? 4.25641  7.44257   -57.09117  1.000 16.07084  ? 111 LYS B N   1 
ATOM   3496 C  CA  . LYS B 1 153 ? 3.08530  6.56561   -56.98599  1.000 18.45872  ? 111 LYS B CA  1 
ATOM   3497 C  C   . LYS B 1 153 ? 3.04968  5.54300   -58.11503  1.000 18.20617  ? 111 LYS B C   1 
ATOM   3498 O  O   . LYS B 1 153 ? 2.81528  4.35651   -57.87870  1.000 17.84091  ? 111 LYS B O   1 
ATOM   3499 C  CB  . LYS B 1 153 ? 1.79342  7.39684   -57.00648  1.000 26.04642  ? 111 LYS B CB  1 
ATOM   3500 C  CG  . LYS B 1 153 ? 0.51360  6.59733   -57.33529  1.000 27.18882  ? 111 LYS B CG  1 
ATOM   3501 C  CD  . LYS B 1 153 ? -0.24003 6.21394   -56.09997  1.000 26.23127  ? 111 LYS B CD  1 
ATOM   3502 C  CE  . LYS B 1 153 ? -1.73759 6.11087   -56.37295  1.000 26.30910  ? 111 LYS B CE  1 
ATOM   3503 N  NZ  . LYS B 1 153 ? -2.09317 5.31870   -57.58200  1.000 31.31126  ? 111 LYS B NZ  1 
ATOM   3504 N  N   . GLY B 1 154 ? 3.27505  5.99419   -59.34316  1.000 21.73143  ? 112 GLY B N   1 
ATOM   3505 C  CA  . GLY B 1 154 ? 3.23173  5.11237   -60.48661  1.000 14.43133  ? 112 GLY B CA  1 
ATOM   3506 C  C   . GLY B 1 154 ? 4.42552  4.18473   -60.44024  1.000 22.80588  ? 112 GLY B C   1 
ATOM   3507 O  O   . GLY B 1 154 ? 5.24840  4.23466   -59.52936  1.000 19.63665  ? 112 GLY B O   1 
ATOM   3508 N  N   . ASP B 1 155 ? 4.49205  3.29330   -61.43496  1.000 19.59627  ? 113 ASP B N   1 
ATOM   3509 C  CA  . ASP B 1 155 ? 5.52889  2.26364   -61.54880  1.000 17.26591  ? 113 ASP B CA  1 
ATOM   3510 C  C   . ASP B 1 155 ? 6.52278  2.78204   -62.57854  1.000 13.06954  ? 113 ASP B C   1 
ATOM   3511 O  O   . ASP B 1 155 ? 6.33238  2.62503   -63.78180  1.000 15.85658  ? 113 ASP B O   1 
ATOM   3512 C  CB  . ASP B 1 155 ? 4.90625  0.94148   -61.99777  1.000 19.62338  ? 113 ASP B CB  1 
ATOM   3513 C  CG  . ASP B 1 155 ? 3.93644  0.36788   -60.98286  1.000 18.66032  ? 113 ASP B CG  1 
ATOM   3514 O  OD1 . ASP B 1 155 ? 4.05595  0.68358   -59.78153  1.000 19.22380  ? 113 ASP B OD1 1 
ATOM   3515 O  OD2 . ASP B 1 155 ? 3.04670  -0.42322  -61.39549  1.000 23.88782  ? 113 ASP B OD2 1 
ATOM   3516 N  N   . VAL B 1 156 ? 7.56053  3.46420   -62.11541  1.000 17.77983  ? 114 VAL B N   1 
ATOM   3517 C  CA  . VAL B 1 156 ? 8.45991  4.18432   -63.00005  1.000 14.17846  ? 114 VAL B CA  1 
ATOM   3518 C  C   . VAL B 1 156 ? 9.86986  3.68969   -62.71305  1.000 13.02864  ? 114 VAL B C   1 
ATOM   3519 O  O   . VAL B 1 156 ? 10.26446 3.55828   -61.55067  1.000 14.20339  ? 114 VAL B O   1 
ATOM   3520 C  CB  . VAL B 1 156 ? 8.30816  5.71113   -62.80478  1.000 16.80174  ? 114 VAL B CB  1 
ATOM   3521 C  CG1 . VAL B 1 156 ? 9.36614  6.53836   -63.61814  1.000 10.48568  ? 114 VAL B CG1 1 
ATOM   3522 C  CG2 . VAL B 1 156 ? 6.88433  6.11301   -63.19610  1.000 10.70300  ? 114 VAL B CG2 1 
ATOM   3523 N  N   . PHE B 1 157 ? 10.59657 3.33925   -63.76278  1.000 10.56807  ? 115 PHE B N   1 
ATOM   3524 C  CA  . PHE B 1 157 ? 11.97903 2.89208   -63.57594  1.000 17.76140  ? 115 PHE B CA  1 
ATOM   3525 C  C   . PHE B 1 157 ? 12.80549 3.94942   -62.86872  1.000 22.25680  ? 115 PHE B C   1 
ATOM   3526 O  O   . PHE B 1 157 ? 12.64098 5.15399   -63.10579  1.000 19.59585  ? 115 PHE B O   1 
ATOM   3527 C  CB  . PHE B 1 157 ? 12.65261 2.60954   -64.91393  1.000 15.23253  ? 115 PHE B CB  1 
ATOM   3528 C  CG  . PHE B 1 157 ? 12.18268 1.35535   -65.57917  1.000 19.22062  ? 115 PHE B CG  1 
ATOM   3529 C  CD1 . PHE B 1 157 ? 12.43449 0.12505   -65.01017  1.000 15.72248  ? 115 PHE B CD1 1 
ATOM   3530 C  CD2 . PHE B 1 157 ? 11.53827 1.41559   -66.79938  1.000 18.43067  ? 115 PHE B CD2 1 
ATOM   3531 C  CE1 . PHE B 1 157 ? 12.03806 -1.05451  -65.64925  1.000 17.67249  ? 115 PHE B CE1 1 
ATOM   3532 C  CE2 . PHE B 1 157 ? 11.13258 0.25711   -67.44312  1.000 20.12486  ? 115 PHE B CE2 1 
ATOM   3533 C  CZ  . PHE B 1 157 ? 11.39006 -0.99005  -66.86287  1.000 18.75296  ? 115 PHE B CZ  1 
ATOM   3534 N  N   . VAL B 1 158 ? 13.69007 3.49100   -61.97930  1.000 19.82657  ? 116 VAL B N   1 
ATOM   3535 C  CA  . VAL B 1 158 ? 14.87100 4.27776   -61.63128  1.000 18.64867  ? 116 VAL B CA  1 
ATOM   3536 C  C   . VAL B 1 158 ? 15.79836 4.30210   -62.83499  1.000 24.42487  ? 116 VAL B C   1 
ATOM   3537 O  O   . VAL B 1 158 ? 16.14635 3.24952   -63.38278  1.000 19.94709  ? 116 VAL B O   1 
ATOM   3538 C  CB  . VAL B 1 158 ? 15.56845 3.68075   -60.40439  1.000 21.25009  ? 116 VAL B CB  1 
ATOM   3539 C  CG1 . VAL B 1 158 ? 16.87380 4.30873   -60.23034  1.000 20.24637  ? 116 VAL B CG1 1 
ATOM   3540 C  CG2 . VAL B 1 158 ? 14.72172 3.91692   -59.17261  1.000 23.22497  ? 116 VAL B CG2 1 
ATOM   3541 N  N   . ILE B 1 159 ? 16.19759 5.50215   -63.27446  1.000 20.61477  ? 117 ILE B N   1 
ATOM   3542 C  CA  . ILE B 1 159 ? 16.93707 5.63066   -64.51806  1.000 12.50359  ? 117 ILE B CA  1 
ATOM   3543 C  C   . ILE B 1 159 ? 18.17324 6.50861   -64.32349  1.000 19.14034  ? 117 ILE B C   1 
ATOM   3544 O  O   . ILE B 1 159 ? 18.35869 7.16779   -63.29780  1.000 21.85785  ? 117 ILE B O   1 
ATOM   3545 C  CB  . ILE B 1 159 ? 16.06494 6.15372   -65.68604  1.000 15.98046  ? 117 ILE B CB  1 
ATOM   3546 C  CG1 . ILE B 1 159 ? 15.63602 7.63452   -65.52375  1.000 13.32255  ? 117 ILE B CG1 1 
ATOM   3547 C  CG2 . ILE B 1 159 ? 14.72857 5.31780   -65.84695  1.000 12.11040  ? 117 ILE B CG2 1 
ATOM   3548 C  CD1 . ILE B 1 159 ? 16.62134 8.57256   -66.23581  1.000 24.70770  ? 117 ILE B CD1 1 
ATOM   3549 N  N   . ARG B 1 160 ? 19.06337 6.42675   -65.30657  1.000 19.61326  ? 118 ARG B N   1 
ATOM   3550 C  CA  . ARG B 1 160 ? 20.13790 7.39087   -65.51178  1.000 19.05830  ? 118 ARG B CA  1 
ATOM   3551 C  C   . ARG B 1 160 ? 20.25612 7.58135   -67.01275  1.000 23.05547  ? 118 ARG B C   1 
ATOM   3552 O  O   . ARG B 1 160 ? 19.78696 6.74395   -67.79456  1.000 18.58761  ? 118 ARG B O   1 
ATOM   3553 C  CB  . ARG B 1 160 ? 21.46776 6.91985   -64.91299  1.000 19.31064  ? 118 ARG B CB  1 
ATOM   3554 C  CG  . ARG B 1 160 ? 21.51172 6.97263   -63.39650  1.000 22.39796  ? 118 ARG B CG  1 
ATOM   3555 C  CD  . ARG B 1 160 ? 21.33803 8.42689   -62.84656  1.000 24.93829  ? 118 ARG B CD  1 
ATOM   3556 N  NE  . ARG B 1 160 ? 22.16006 9.39334   -63.57233  1.000 24.22115  ? 118 ARG B NE  1 
ATOM   3557 C  CZ  . ARG B 1 160 ? 23.45457 9.58212   -63.36518  1.000 28.24936  ? 118 ARG B CZ  1 
ATOM   3558 N  NH1 . ARG B 1 160 ? 24.11869 8.87546   -62.46154  1.000 39.11752  ? 118 ARG B NH1 1 
ATOM   3559 N  NH2 . ARG B 1 160 ? 24.10582 10.48169  -64.10314  1.000 22.32378  ? 118 ARG B NH2 1 
ATOM   3560 N  N   . GLU B 1 161 ? 20.92189 8.67026   -67.40147  1.000 22.72797  ? 119 GLU B N   1 
ATOM   3561 C  CA  . GLU B 1 161 ? 21.18690 9.01360   -68.79428  1.000 19.67932  ? 119 GLU B CA  1 
ATOM   3562 C  C   . GLU B 1 161 ? 19.97112 8.93323   -69.72082  1.000 18.43530  ? 119 GLU B C   1 
ATOM   3563 O  O   . GLU B 1 161 ? 20.00234 8.21680   -70.71931  1.000 21.59509  ? 119 GLU B O   1 
ATOM   3564 C  CB  . GLU B 1 161 ? 22.30090 8.14268   -69.35552  1.000 24.08203  ? 119 GLU B CB  1 
ATOM   3565 C  CG  . GLU B 1 161 ? 23.20305 7.56155   -68.34440  1.000 34.64757  ? 119 GLU B CG  1 
ATOM   3566 C  CD  . GLU B 1 161 ? 24.17810 6.65038   -69.00830  1.000 35.17013  ? 119 GLU B CD  1 
ATOM   3567 O  OE1 . GLU B 1 161 ? 25.30256 6.50380   -68.45943  1.000 46.04799  ? 119 GLU B OE1 1 
ATOM   3568 O  OE2 . GLU B 1 161 ? 23.81034 6.11861   -70.09874  1.000 37.19204  ? 119 GLU B OE2 1 
ATOM   3569 N  N   . PRO B 1 162 ? 18.93776 9.73418   -69.47407  1.000 18.28211  ? 120 PRO B N   1 
ATOM   3570 C  CA  . PRO B 1 162 ? 17.77122 9.75166   -70.38577  1.000 23.48158  ? 120 PRO B CA  1 
ATOM   3571 C  C   . PRO B 1 162 ? 18.02707 10.51507  -71.68145  1.000 28.81810  ? 120 PRO B C   1 
ATOM   3572 O  O   . PRO B 1 162 ? 17.46899 11.61340  -71.90956  1.000 28.86281  ? 120 PRO B O   1 
ATOM   3573 C  CB  . PRO B 1 162 ? 16.70468 10.44129  -69.52359  1.000 22.99766  ? 120 PRO B CB  1 
ATOM   3574 C  CG  . PRO B 1 162 ? 17.52847 11.44982  -68.71147  1.000 25.73030  ? 120 PRO B CG  1 
ATOM   3575 C  CD  . PRO B 1 162 ? 18.81938 10.71309  -68.38158  1.000 20.60421  ? 120 PRO B CD  1 
ATOM   3576 N  N   . PHE B 1 163 ? 18.82300 9.94995   -72.59577  1.000 14.73770  ? 121 PHE B N   1 
ATOM   3577 C  CA  . PHE B 1 163 ? 19.19173 10.69512  -73.79606  1.000 19.58352  ? 121 PHE B CA  1 
ATOM   3578 C  C   . PHE B 1 163 ? 18.17063 10.52899  -74.91966  1.000 21.35186  ? 121 PHE B C   1 
ATOM   3579 O  O   . PHE B 1 163 ? 17.55958 9.47855   -75.08271  1.000 21.09756  ? 121 PHE B O   1 
ATOM   3580 C  CB  . PHE B 1 163 ? 20.59245 10.32553  -74.28796  1.000 17.10786  ? 121 PHE B CB  1 
ATOM   3581 C  CG  . PHE B 1 163 ? 20.74364 8.90455   -74.82593  1.000 21.26838  ? 121 PHE B CG  1 
ATOM   3582 C  CD1 . PHE B 1 163 ? 21.12696 7.87426   -73.97811  1.000 13.50202  ? 121 PHE B CD1 1 
ATOM   3583 C  CD2 . PHE B 1 163 ? 20.56362 8.63105   -76.17935  1.000 17.45363  ? 121 PHE B CD2 1 
ATOM   3584 C  CE1 . PHE B 1 163 ? 21.32943 6.56548   -74.46951  1.000 16.17418  ? 121 PHE B CE1 1 
ATOM   3585 C  CE2 . PHE B 1 163 ? 20.75584 7.34257   -76.67711  1.000 18.45551  ? 121 PHE B CE2 1 
ATOM   3586 C  CZ  . PHE B 1 163 ? 21.13779 6.31205   -75.82523  1.000 13.85336  ? 121 PHE B CZ  1 
ATOM   3587 N  N   . ILE B 1 164 ? 18.02708 11.56633  -75.73265  1.000 14.79115  ? 122 ILE B N   1 
ATOM   3588 C  CA  . ILE B 1 164 ? 17.01996 11.55554  -76.79188  1.000 16.13478  ? 122 ILE B CA  1 
ATOM   3589 C  C   . ILE B 1 164 ? 17.66879 11.28106  -78.14156  1.000 15.80834  ? 122 ILE B C   1 
ATOM   3590 O  O   . ILE B 1 164 ? 18.78112 11.72382  -78.43242  1.000 19.69056  ? 122 ILE B O   1 
ATOM   3591 C  CB  . ILE B 1 164 ? 16.24294 12.89803  -76.81199  1.000 16.10184  ? 122 ILE B CB  1 
ATOM   3592 C  CG1 . ILE B 1 164 ? 15.48699 13.10258  -75.49647  1.000 19.71343  ? 122 ILE B CG1 1 
ATOM   3593 C  CG2 . ILE B 1 164 ? 15.24957 12.94577  -77.98893  1.000 16.96282  ? 122 ILE B CG2 1 
ATOM   3594 C  CD1 . ILE B 1 164 ? 14.61029 14.40871  -75.51802  1.000 14.88746  ? 122 ILE B CD1 1 
ATOM   3595 N  N   . SER B 1 165 ? 16.94267 10.58788  -79.00087  1.000 14.53986  ? 123 SER B N   1 
ATOM   3596 C  CA  . SER B 1 165 ? 17.38308 10.36104  -80.36506  1.000 21.55607  ? 123 SER B CA  1 
ATOM   3597 C  C   . SER B 1 165 ? 16.11958 10.21230  -81.18983  1.000 16.37851  ? 123 SER B C   1 
ATOM   3598 O  O   . SER B 1 165 ? 15.09413 9.74574   -80.68802  1.000 18.16925  ? 123 SER B O   1 
ATOM   3599 C  CB  . SER B 1 165 ? 18.31199 9.11423   -80.50268  1.000 14.79839  ? 123 SER B CB  1 
ATOM   3600 O  OG  . SER B 1 165 ? 18.85277 9.02898   -81.82469  1.000 19.19281  ? 123 SER B OG  1 
ATOM   3601 N  N   . CYS B 1 166 ? 16.20178 10.61130  -82.45724  1.000 21.46895  ? 124 CYS B N   1 
ATOM   3602 C  CA  . CYS B 1 166 ? 15.04095 10.71932  -83.32811  1.000 28.71612  ? 124 CYS B CA  1 
ATOM   3603 C  C   . CYS B 1 166 ? 15.22135 9.90644   -84.60583  1.000 26.37789  ? 124 CYS B C   1 
ATOM   3604 O  O   . CYS B 1 166 ? 16.31387 9.84014   -85.17043  1.000 28.89197  ? 124 CYS B O   1 
ATOM   3605 C  CB  . CYS B 1 166 ? 14.78792 12.18537  -83.68846  1.000 25.24069  ? 124 CYS B CB  1 
ATOM   3606 S  SG  . CYS B 1 166 ? 14.58071 13.28662  -82.26641  1.000 27.27542  ? 124 CYS B SG  1 
ATOM   3607 N  N   . SER B 1 167 ? 14.14302 9.31364   -85.08936  1.000 28.33953  ? 125 SER B N   1 
ATOM   3608 C  CA  . SER B 1 167 ? 14.18436 8.77349   -86.43963  1.000 32.30875  ? 125 SER B CA  1 
ATOM   3609 C  C   . SER B 1 167 ? 13.74645 9.85937   -87.42902  1.000 38.09863  ? 125 SER B C   1 
ATOM   3610 O  O   . SER B 1 167 ? 13.86620 11.06011  -87.17362  1.000 37.33426  ? 125 SER B O   1 
ATOM   3611 C  CB  . SER B 1 167 ? 13.30489 7.53735   -86.53728  1.000 25.11412  ? 125 SER B CB  1 
ATOM   3612 O  OG  . SER B 1 167 ? 11.97365 7.90652   -86.26278  1.000 35.06294  ? 125 SER B OG  1 
ATOM   3613 N  N   . HIS B 1 168 ? 13.27575 9.44229   -88.59022  1.000 40.50145  ? 126 HIS B N   1 
ATOM   3614 C  CA  . HIS B 1 168 ? 12.57571 10.31343  -89.51354  1.000 41.60051  ? 126 HIS B CA  1 
ATOM   3615 C  C   . HIS B 1 168 ? 11.09349 10.40147  -89.16301  1.000 42.11143  ? 126 HIS B C   1 
ATOM   3616 O  O   . HIS B 1 168 ? 10.36305 11.15785  -89.81013  1.000 42.41329  ? 126 HIS B O   1 
ATOM   3617 C  CB  . HIS B 1 168 ? 12.74469 9.77983   -90.94484  1.000 36.07162  ? 126 HIS B CB  1 
ATOM   3618 C  CG  . HIS B 1 168 ? 12.25074 8.36794   -91.11592  1.000 47.85665  ? 126 HIS B CG  1 
ATOM   3619 N  ND1 . HIS B 1 168 ? 12.53435 7.35948   -90.21594  1.000 50.14655  ? 126 HIS B ND1 1 
ATOM   3620 C  CD2 . HIS B 1 168 ? 11.48475 7.79928   -92.07871  1.000 45.56425  ? 126 HIS B CD2 1 
ATOM   3621 C  CE1 . HIS B 1 168 ? 11.96409 6.23438   -90.61313  1.000 48.11692  ? 126 HIS B CE1 1 
ATOM   3622 N  NE2 . HIS B 1 168 ? 11.32339 6.47319   -91.74298  1.000 50.03159  ? 126 HIS B NE2 1 
ATOM   3623 N  N   . LEU B 1 169 ? 10.64590 9.66036   -88.13808  1.000 34.82048  ? 127 LEU B N   1 
ATOM   3624 C  CA  . LEU B 1 169 ? 9.23321  9.58702   -87.77670  1.000 36.52876  ? 127 LEU B CA  1 
ATOM   3625 C  C   . LEU B 1 169 ? 8.87578  9.91857   -86.32875  1.000 42.41265  ? 127 LEU B C   1 
ATOM   3626 O  O   . LEU B 1 169 ? 7.72583  10.28020  -86.05708  1.000 47.41651  ? 127 LEU B O   1 
ATOM   3627 C  CB  . LEU B 1 169 ? 8.72089  8.17139   -88.02722  1.000 39.12831  ? 127 LEU B CB  1 
ATOM   3628 C  CG  . LEU B 1 169 ? 9.00448  7.51382   -89.37492  1.000 57.23221  ? 127 LEU B CG  1 
ATOM   3629 C  CD1 . LEU B 1 169 ? 8.50144  6.06087   -89.36858  1.000 47.91516  ? 127 LEU B CD1 1 
ATOM   3630 C  CD2 . LEU B 1 169 ? 8.43838  8.32253   -90.53560  1.000 44.04470  ? 127 LEU B CD2 1 
ATOM   3631 N  N   . GLU B 1 170 ? 9.80142  9.73141   -85.38350  1.000 29.65793  ? 128 GLU B N   1 
ATOM   3632 C  CA  . GLU B 1 170 ? 9.51135  9.99868   -83.97498  1.000 30.32687  ? 128 GLU B CA  1 
ATOM   3633 C  C   . GLU B 1 170 ? 10.81859 10.16768  -83.21448  1.000 24.03431  ? 128 GLU B C   1 
ATOM   3634 O  O   . GLU B 1 170 ? 11.89208 9.82588   -83.71377  1.000 30.72806  ? 128 GLU B O   1 
ATOM   3635 C  CB  . GLU B 1 170 ? 8.64339  8.88688   -83.35432  1.000 35.17483  ? 128 GLU B CB  1 
ATOM   3636 C  CG  . GLU B 1 170 ? 9.41688  7.85837   -82.53309  1.000 39.46947  ? 128 GLU B CG  1 
ATOM   3637 C  CD  . GLU B 1 170 ? 8.56240  6.75339   -81.88702  1.000 48.86565  ? 128 GLU B CD  1 
ATOM   3638 O  OE1 . GLU B 1 170 ? 7.55273  7.06265   -81.20297  1.000 54.55386  ? 128 GLU B OE1 1 
ATOM   3639 O  OE2 . GLU B 1 170 ? 8.95305  5.56774   -82.01465  1.000 41.68581  ? 128 GLU B OE2 1 
ATOM   3640 N  N   . CYS B 1 171 ? 10.70871 10.71143  -81.99525  1.000 22.37424  ? 129 CYS B N   1 
ATOM   3641 C  CA  . CYS B 1 171 ? 11.82732 10.93940  -81.08405  1.000 21.63169  ? 129 CYS B CA  1 
ATOM   3642 C  C   . CYS B 1 171 ? 11.60435 10.11738  -79.82901  1.000 31.12303  ? 129 CYS B C   1 
ATOM   3643 O  O   . CYS B 1 171 ? 10.48137 10.06363  -79.30696  1.000 20.35147  ? 129 CYS B O   1 
ATOM   3644 C  CB  . CYS B 1 171 ? 11.97675 12.41078  -80.69464  1.000 24.67792  ? 129 CYS B CB  1 
ATOM   3645 S  SG  . CYS B 1 171 ? 12.51587 13.48055  -82.05734  1.000 37.81434  ? 129 CYS B SG  1 
ATOM   3646 N  N   . ARG B 1 172 ? 12.66790 9.46118   -79.34921  1.000 18.54150  ? 130 ARG B N   1 
ATOM   3647 C  CA  . ARG B 1 172 ? 12.54341 8.61824   -78.17622  1.000 12.79717  ? 130 ARG B CA  1 
ATOM   3648 C  C   . ARG B 1 172 ? 13.54627 9.02339   -77.11308  1.000 18.65073  ? 130 ARG B C   1 
ATOM   3649 O  O   . ARG B 1 172 ? 14.63420 9.55005   -77.40668  1.000 14.90673  ? 130 ARG B O   1 
ATOM   3650 C  CB  . ARG B 1 172 ? 12.71072 7.12202   -78.54198  1.000 20.14132  ? 130 ARG B CB  1 
ATOM   3651 C  CG  . ARG B 1 172 ? 11.75670 6.66237   -79.61872  1.000 17.29473  ? 130 ARG B CG  1 
ATOM   3652 C  CD  . ARG B 1 172 ? 11.93993 5.16503   -79.97252  1.000 22.35518  ? 130 ARG B CD  1 
ATOM   3653 N  NE  . ARG B 1 172 ? 11.59584 4.27529   -78.86757  1.000 18.52308  ? 130 ARG B NE  1 
ATOM   3654 C  CZ  . ARG B 1 172 ? 10.36142 3.92977   -78.51570  1.000 27.12734  ? 130 ARG B CZ  1 
ATOM   3655 N  NH1 . ARG B 1 172 ? 9.29267  4.36960   -79.17403  1.000 19.26627  ? 130 ARG B NH1 1 
ATOM   3656 N  NH2 . ARG B 1 172 ? 10.18909 3.13591   -77.46534  1.000 21.54274  ? 130 ARG B NH2 1 
ATOM   3657 N  N   . THR B 1 173 ? 13.17090 8.76844   -75.86616  1.000 18.85099  ? 131 THR B N   1 
ATOM   3658 C  CA  . THR B 1 173 ? 14.11322 8.83651   -74.75912  1.000 16.49082  ? 131 THR B CA  1 
ATOM   3659 C  C   . THR B 1 173 ? 14.65843 7.43367   -74.54176  1.000 22.31792  ? 131 THR B C   1 
ATOM   3660 O  O   . THR B 1 173 ? 13.90263 6.51137   -74.23503  1.000 15.96659  ? 131 THR B O   1 
ATOM   3661 C  CB  . THR B 1 173 ? 13.43178 9.36347   -73.51098  1.000 18.07818  ? 131 THR B CB  1 
ATOM   3662 O  OG1 . THR B 1 173 ? 13.08060 10.73002  -73.75129  1.000 21.04262  ? 131 THR B OG1 1 
ATOM   3663 C  CG2 . THR B 1 173 ? 14.35398 9.30635   -72.30188  1.000 14.34628  ? 131 THR B CG2 1 
ATOM   3664 N  N   . PHE B 1 174 ? 15.95048 7.26300   -74.78674  1.000 19.81674  ? 132 PHE B N   1 
ATOM   3665 C  CA  . PHE B 1 174 ? 16.68068 6.07136   -74.38861  1.000 18.02520  ? 132 PHE B CA  1 
ATOM   3666 C  C   . PHE B 1 174 ? 17.17544 6.32181   -72.98215  1.000 16.49580  ? 132 PHE B C   1 
ATOM   3667 O  O   . PHE B 1 174 ? 17.31855 7.46869   -72.57560  1.000 18.24183  ? 132 PHE B O   1 
ATOM   3668 C  CB  . PHE B 1 174 ? 17.83646 5.82756   -75.34735  1.000 18.65941  ? 132 PHE B CB  1 
ATOM   3669 C  CG  . PHE B 1 174 ? 17.39845 5.38756   -76.70824  1.000 16.03395  ? 132 PHE B CG  1 
ATOM   3670 C  CD1 . PHE B 1 174 ? 16.90755 6.28696   -77.62604  1.000 17.07710  ? 132 PHE B CD1 1 
ATOM   3671 C  CD2 . PHE B 1 174 ? 17.46697 4.05150   -77.05537  1.000 13.79408  ? 132 PHE B CD2 1 
ATOM   3672 C  CE1 . PHE B 1 174 ? 16.51222 5.86479   -78.87294  1.000 18.24412  ? 132 PHE B CE1 1 
ATOM   3673 C  CE2 . PHE B 1 174 ? 17.07931 3.62945   -78.29313  1.000 19.88388  ? 132 PHE B CE2 1 
ATOM   3674 C  CZ  . PHE B 1 174 ? 16.60822 4.52224   -79.20556  1.000 15.87479  ? 132 PHE B CZ  1 
ATOM   3675 N  N   . PHE B 1 175 ? 17.36468 5.25793   -72.21424  1.000 13.17751  ? 133 PHE B N   1 
ATOM   3676 C  CA  . PHE B 1 175 ? 17.81248 5.43889   -70.83988  1.000 17.33274  ? 133 PHE B CA  1 
ATOM   3677 C  C   . PHE B 1 175 ? 18.32497 4.09816   -70.34146  1.000 18.35949  ? 133 PHE B C   1 
ATOM   3678 O  O   . PHE B 1 175 ? 18.05997 3.06139   -70.95186  1.000 18.15550  ? 133 PHE B O   1 
ATOM   3679 C  CB  . PHE B 1 175 ? 16.69983 5.99326   -69.92451  1.000 17.09958  ? 133 PHE B CB  1 
ATOM   3680 C  CG  . PHE B 1 175 ? 15.45268 5.12327   -69.88322  1.000 16.05702  ? 133 PHE B CG  1 
ATOM   3681 C  CD1 . PHE B 1 175 ? 15.36246 4.02221   -68.98578  1.000 16.03528  ? 133 PHE B CD1 1 
ATOM   3682 C  CD2 . PHE B 1 175 ? 14.40479 5.36770   -70.75997  1.000 15.27375  ? 133 PHE B CD2 1 
ATOM   3683 C  CE1 . PHE B 1 175 ? 14.20307 3.18758   -68.93947  1.000 17.19641  ? 133 PHE B CE1 1 
ATOM   3684 C  CE2 . PHE B 1 175 ? 13.22996 4.52848   -70.73178  1.000 16.97567  ? 133 PHE B CE2 1 
ATOM   3685 C  CZ  . PHE B 1 175 ? 13.13293 3.45773   -69.80985  1.000 10.97214  ? 133 PHE B CZ  1 
ATOM   3686 N  N   . LEU B 1 176 ? 19.10546 4.14041   -69.25244  1.000 12.60474  ? 134 LEU B N   1 
ATOM   3687 C  CA  . LEU B 1 176 ? 19.63741 2.94864   -68.60387  1.000 19.08421  ? 134 LEU B CA  1 
ATOM   3688 C  C   . LEU B 1 176 ? 18.92571 2.76362   -67.27584  1.000 18.56855  ? 134 LEU B C   1 
ATOM   3689 O  O   . LEU B 1 176 ? 18.75714 3.73060   -66.52542  1.000 17.67520  ? 134 LEU B O   1 
ATOM   3690 C  CB  . LEU B 1 176 ? 21.15287 3.07768   -68.34099  1.000 14.87594  ? 134 LEU B CB  1 
ATOM   3691 C  CG  . LEU B 1 176 ? 22.08815 3.21549   -69.52568  1.000 19.20464  ? 134 LEU B CG  1 
ATOM   3692 C  CD1 . LEU B 1 176 ? 23.57478 3.36617   -69.05298  1.000 22.96916  ? 134 LEU B CD1 1 
ATOM   3693 C  CD2 . LEU B 1 176 ? 21.94080 1.97713   -70.38318  1.000 16.19315  ? 134 LEU B CD2 1 
ATOM   3694 N  N   . THR B 1 177 ? 18.56893 1.52282   -66.93619  1.000 19.76819  ? 135 THR B N   1 
ATOM   3695 C  CA  . THR B 1 177 ? 17.95987 1.28238   -65.62983  1.000 15.54516  ? 135 THR B CA  1 
ATOM   3696 C  C   . THR B 1 177 ? 18.55390 0.04741   -64.97846  1.000 18.39514  ? 135 THR B C   1 
ATOM   3697 O  O   . THR B 1 177 ? 18.91692 -0.90445  -65.66880  1.000 23.66228  ? 135 THR B O   1 
ATOM   3698 C  CB  . THR B 1 177 ? 16.43481 1.09919   -65.74892  1.000 17.03424  ? 135 THR B CB  1 
ATOM   3699 O  OG1 . THR B 1 177 ? 15.90339 0.63832   -64.49909  1.000 24.88263  ? 135 THR B OG1 1 
ATOM   3700 C  CG2 . THR B 1 177 ? 16.03312 0.08042   -66.87757  1.000 21.41478  ? 135 THR B CG2 1 
ATOM   3701 N  N   . GLN B 1 178 ? 18.57775 0.02638   -63.63921  1.000 19.26636  ? 136 GLN B N   1 
ATOM   3702 C  CA  . GLN B 1 178 ? 18.92301 -1.21126  -62.91940  1.000 20.04941  ? 136 GLN B CA  1 
ATOM   3703 C  C   . GLN B 1 178 ? 17.79402 -2.22777  -62.89641  1.000 30.54463  ? 136 GLN B C   1 
ATOM   3704 O  O   . GLN B 1 178 ? 17.90960 -3.25942  -62.21726  1.000 26.40234  ? 136 GLN B O   1 
ATOM   3705 C  CB  . GLN B 1 178 ? 19.32083 -0.90692  -61.47704  1.000 25.08325  ? 136 GLN B CB  1 
ATOM   3706 C  CG  . GLN B 1 178 ? 20.66708 -0.12188  -61.35205  1.000 32.62791  ? 136 GLN B CG  1 
ATOM   3707 C  CD  . GLN B 1 178 ? 21.91530 -1.02220  -61.48970  1.000 45.01493  ? 136 GLN B CD  1 
ATOM   3708 O  OE1 . GLN B 1 178 ? 21.81103 -2.25540  -61.57280  1.000 27.22909  ? 136 GLN B OE1 1 
ATOM   3709 N  NE2 . GLN B 1 178 ? 23.10161 -0.39817  -61.47608  1.000 33.74536  ? 136 GLN B NE2 1 
ATOM   3710 N  N   . GLY B 1 179 ? 16.70591 -1.96968  -63.60691  1.000 19.10836  ? 137 GLY B N   1 
ATOM   3711 C  CA  . GLY B 1 179 ? 15.58148 -2.86202  -63.51128  1.000 20.00163  ? 137 GLY B CA  1 
ATOM   3712 C  C   . GLY B 1 179 ? 14.94156 -2.76958  -62.14712  1.000 30.09454  ? 137 GLY B C   1 
ATOM   3713 O  O   . GLY B 1 179 ? 14.54319 -3.79494  -61.56962  1.000 32.20992  ? 137 GLY B O   1 
ATOM   3714 N  N   . ALA B 1 180 ? 14.84532 -1.56755  -61.60441  1.000 15.51783  ? 138 ALA B N   1 
ATOM   3715 C  CA  . ALA B 1 180 ? 14.16234 -1.35210  -60.34379  1.000 21.05867  ? 138 ALA B CA  1 
ATOM   3716 C  C   . ALA B 1 180 ? 13.25142 -0.13393  -60.48075  1.000 21.86357  ? 138 ALA B C   1 
ATOM   3717 O  O   . ALA B 1 180 ? 13.54033 0.78958   -61.25399  1.000 20.53219  ? 138 ALA B O   1 
ATOM   3718 C  CB  . ALA B 1 180 ? 15.16832 -1.15977  -59.20237  1.000 18.33343  ? 138 ALA B CB  1 
ATOM   3719 N  N   . LEU B 1 181 ? 12.17065 -0.12121  -59.69895  1.000 16.34162  ? 139 LEU B N   1 
ATOM   3720 C  CA  . LEU B 1 181 ? 11.19690 0.96559   -59.75326  1.000 16.49661  ? 139 LEU B CA  1 
ATOM   3721 C  C   . LEU B 1 181 ? 11.35647 1.91150   -58.56786  1.000 14.93621  ? 139 LEU B C   1 
ATOM   3722 O  O   . LEU B 1 181 ? 11.77494 1.51647   -57.47445  1.000 15.77864  ? 139 LEU B O   1 
ATOM   3723 C  CB  . LEU B 1 181 ? 9.76461  0.41848   -59.77568  1.000 13.47859  ? 139 LEU B CB  1 
ATOM   3724 C  CG  . LEU B 1 181 ? 9.43285  -0.56990  -60.89051  1.000 18.38481  ? 139 LEU B CG  1 
ATOM   3725 C  CD1 . LEU B 1 181 ? 7.94441  -0.88839  -60.91720  1.000 14.49483  ? 139 LEU B CD1 1 
ATOM   3726 C  CD2 . LEU B 1 181 ? 9.88416  -0.07423  -62.25839  1.000 12.53418  ? 139 LEU B CD2 1 
ATOM   3727 N  N   . LEU B 1 182 ? 10.97532 3.16719   -58.78490  1.000 18.57126  ? 140 LEU B N   1 
ATOM   3728 C  CA  . LEU B 1 182 ? 11.02480 4.14885   -57.71111  1.000 17.33803  ? 140 LEU B CA  1 
ATOM   3729 C  C   . LEU B 1 182 ? 10.16437 3.69297   -56.55739  1.000 19.88381  ? 140 LEU B C   1 
ATOM   3730 O  O   . LEU B 1 182 ? 9.12370  3.05380   -56.75805  1.000 20.28039  ? 140 LEU B O   1 
ATOM   3731 C  CB  . LEU B 1 182 ? 10.55965 5.52973   -58.21294  1.000 18.19624  ? 140 LEU B CB  1 
ATOM   3732 C  CG  . LEU B 1 182 ? 11.54803 6.26712   -59.12224  1.000 15.79733  ? 140 LEU B CG  1 
ATOM   3733 C  CD1 . LEU B 1 182 ? 10.82760 7.32698   -60.00514  1.000 22.19978  ? 140 LEU B CD1 1 
ATOM   3734 C  CD2 . LEU B 1 182 ? 12.65851 6.91038   -58.29796  1.000 22.78678  ? 140 LEU B CD2 1 
ATOM   3735 N  N   . ASN B 1 183 ? 10.62200 3.98977   -55.33336  1.000 19.28399  ? 141 ASN B N   1 
ATOM   3736 C  CA  . ASN B 1 183 ? 9.86541  3.64382   -54.12215  1.000 21.80646  ? 141 ASN B CA  1 
ATOM   3737 C  C   . ASN B 1 183 ? 9.76195  2.13357   -53.88492  1.000 20.03385  ? 141 ASN B C   1 
ATOM   3738 O  O   . ASN B 1 183 ? 8.81103  1.66889   -53.24824  1.000 25.07088  ? 141 ASN B O   1 
ATOM   3739 C  CB  . ASN B 1 183 ? 8.46075  4.25657   -54.13910  1.000 20.19948  ? 141 ASN B CB  1 
ATOM   3740 C  CG  . ASN B 1 183 ? 8.28076  5.29276   -53.05860  1.000 19.74583  ? 141 ASN B CG  1 
ATOM   3741 O  OD1 . ASN B 1 183 ? 9.04206  5.32106   -52.08174  1.000 21.14750  ? 141 ASN B OD1 1 
ATOM   3742 N  ND2 . ASN B 1 183 ? 7.26061  6.12282   -53.19659  1.000 18.89167  ? 141 ASN B ND2 1 
ATOM   3743 N  N   . ASP B 1 184 ? 10.73826 1.36624   -54.36842  1.000 22.64129  ? 142 ASP B N   1 
ATOM   3744 C  CA  . ASP B 1 184 ? 10.84350 -0.06245  -54.08538  1.000 16.80451  ? 142 ASP B CA  1 
ATOM   3745 C  C   . ASP B 1 184 ? 12.23159 -0.36569  -53.54993  1.000 17.85917  ? 142 ASP B C   1 
ATOM   3746 O  O   . ASP B 1 184 ? 13.20344 0.32155   -53.88600  1.000 20.85737  ? 142 ASP B O   1 
ATOM   3747 C  CB  . ASP B 1 184 ? 10.57535 -0.87527  -55.34972  1.000 22.69073  ? 142 ASP B CB  1 
ATOM   3748 C  CG  . ASP B 1 184 ? 10.71362 -2.37679  -55.12543  1.000 26.25857  ? 142 ASP B CG  1 
ATOM   3749 O  OD1 . ASP B 1 184 ? 9.80837  -2.98717  -54.47295  1.000 21.37772  ? 142 ASP B OD1 1 
ATOM   3750 O  OD2 . ASP B 1 184 ? 11.73102 -2.92782  -55.62148  1.000 17.99208  ? 142 ASP B OD2 1 
ATOM   3751 N  N   . LYS B 1 185 ? 12.32879 -1.40599  -52.71014  1.000 20.78924  ? 143 LYS B N   1 
ATOM   3752 C  CA  . LYS B 1 185 ? 13.59905 -1.70915  -52.05033  1.000 16.65331  ? 143 LYS B CA  1 
ATOM   3753 C  C   . LYS B 1 185 ? 14.71079 -1.99891  -53.05244  1.000 19.22005  ? 143 LYS B C   1 
ATOM   3754 O  O   . LYS B 1 185 ? 15.88849 -1.77338  -52.75033  1.000 18.80691  ? 143 LYS B O   1 
ATOM   3755 C  CB  . LYS B 1 185 ? 13.41939 -2.87275  -51.07138  1.000 24.68655  ? 143 LYS B CB  1 
ATOM   3756 C  CG  . LYS B 1 185 ? 13.12271 -4.20239  -51.72029  1.000 17.43656  ? 143 LYS B CG  1 
ATOM   3757 C  CD  . LYS B 1 185 ? 13.05728 -5.30120  -50.69120  1.000 23.65745  ? 143 LYS B CD  1 
ATOM   3758 C  CE  . LYS B 1 185 ? 12.67692 -6.61332  -51.35087  1.000 22.74004  ? 143 LYS B CE  1 
ATOM   3759 N  NZ  . LYS B 1 185 ? 12.77157 -7.71028  -50.37170  1.000 27.38192  ? 143 LYS B NZ  1 
ATOM   3760 N  N   . HIS B 1 186 ? 14.36893 -2.47714  -54.25297  1.000 14.47174  ? 144 HIS B N   1 
ATOM   3761 C  CA  . HIS B 1 186 ? 15.39711 -2.74702  -55.24916  1.000 17.15569  ? 144 HIS B CA  1 
ATOM   3762 C  C   . HIS B 1 186 ? 16.04119 -1.49843  -55.81965  1.000 21.24442  ? 144 HIS B C   1 
ATOM   3763 O  O   . HIS B 1 186 ? 17.03538 -1.62596  -56.55200  1.000 21.09845  ? 144 HIS B O   1 
ATOM   3764 C  CB  . HIS B 1 186 ? 14.80353 -3.56684  -56.38798  1.000 16.07947  ? 144 HIS B CB  1 
ATOM   3765 C  CG  . HIS B 1 186 ? 14.44347 -4.96536  -55.96876  1.000 15.65719  ? 144 HIS B CG  1 
ATOM   3766 N  ND1 . HIS B 1 186 ? 13.16140 -5.31700  -55.58927  1.000 13.26641  ? 144 HIS B ND1 1 
ATOM   3767 C  CD2 . HIS B 1 186 ? 15.20340 -6.08021  -55.81051  1.000 17.08874  ? 144 HIS B CD2 1 
ATOM   3768 C  CE1 . HIS B 1 186 ? 13.13477 -6.60353  -55.26218  1.000 16.74372  ? 144 HIS B CE1 1 
ATOM   3769 N  NE2 . HIS B 1 186 ? 14.35970 -7.08973  -55.38888  1.000 14.03494  ? 144 HIS B NE2 1 
ATOM   3770 N  N   . SER B 1 187 ? 15.47456 -0.30236  -55.56936  1.000 19.87454  ? 145 SER B N   1 
ATOM   3771 C  CA  . SER B 1 187 ? 16.15008 0.92095   -56.01417  1.000 15.24229  ? 145 SER B CA  1 
ATOM   3772 C  C   . SER B 1 187 ? 17.36567 1.26377   -55.14511  1.000 21.52685  ? 145 SER B C   1 
ATOM   3773 O  O   . SER B 1 187 ? 18.08435 2.22631   -55.46343  1.000 16.84912  ? 145 SER B O   1 
ATOM   3774 C  CB  . SER B 1 187 ? 15.13815 2.07787   -56.04678  1.000 14.96105  ? 145 SER B CB  1 
ATOM   3775 O  OG  . SER B 1 187 ? 14.70585 2.34852   -54.72813  1.000 17.15392  ? 145 SER B OG  1 
ATOM   3776 N  N   . ASN B 1 188 ? 17.59597 0.48315   -54.08095  1.000 22.95122  ? 146 ASN B N   1 
ATOM   3777 C  CA  . ASN B 1 188 ? 18.76135 0.58877   -53.20427  1.000 27.05366  ? 146 ASN B CA  1 
ATOM   3778 C  C   . ASN B 1 188 ? 20.02102 0.65448   -54.03860  1.000 31.49095  ? 146 ASN B C   1 
ATOM   3779 O  O   . ASN B 1 188 ? 20.29546 -0.25666  -54.82490  1.000 27.24887  ? 146 ASN B O   1 
ATOM   3780 C  CB  . ASN B 1 188 ? 18.81497 -0.64366  -52.28727  1.000 33.97246  ? 146 ASN B CB  1 
ATOM   3781 C  CG  . ASN B 1 188 ? 19.90285 -0.56034  -51.21018  1.000 51.82619  ? 146 ASN B CG  1 
ATOM   3782 O  OD1 . ASN B 1 188 ? 20.61343 0.42769   -51.10814  1.000 56.97508  ? 146 ASN B OD1 1 
ATOM   3783 N  ND2 . ASN B 1 188 ? 20.03689 -1.64281  -50.41466  1.000 71.18534  ? 146 ASN B ND2 1 
ATOM   3784 N  N   . GLY B 1 189 ? 20.77493 1.74355   -53.87529  1.000 26.18941  ? 147 GLY B N   1 
ATOM   3785 C  CA  . GLY B 1 189 ? 21.91574 2.07706   -54.68433  1.000 28.49965  ? 147 GLY B CA  1 
ATOM   3786 C  C   . GLY B 1 189 ? 23.21993 1.48407   -54.20514  1.000 44.98424  ? 147 GLY B C   1 
ATOM   3787 O  O   . GLY B 1 189 ? 24.27541 1.89019   -54.70019  1.000 52.35808  ? 147 GLY B O   1 
ATOM   3788 N  N   . THR B 1 190 ? 23.18171 0.55686   -53.23718  1.000 53.98958  ? 148 THR B N   1 
ATOM   3789 C  CA  . THR B 1 190 ? 24.38132 -0.19784  -52.87254  1.000 65.59515  ? 148 THR B CA  1 
ATOM   3790 C  C   . THR B 1 190 ? 24.93382 -0.93797  -54.09164  1.000 61.85841  ? 148 THR B C   1 
ATOM   3791 O  O   . THR B 1 190 ? 26.15360 -1.04900  -54.26257  1.000 66.20554  ? 148 THR B O   1 
ATOM   3792 C  CB  . THR B 1 190 ? 24.06412 -1.21107  -51.75209  1.000 66.80334  ? 148 THR B CB  1 
ATOM   3793 O  OG1 . THR B 1 190 ? 23.58959 -0.54067  -50.57543  1.000 62.55013  ? 148 THR B OG1 1 
ATOM   3794 C  CG2 . THR B 1 190 ? 25.32333 -2.00794  -51.36849  1.000 58.38157  ? 148 THR B CG2 1 
ATOM   3795 N  N   . ILE B 1 191 ? 24.03856 -1.45139  -54.94635  1.000 60.88108  ? 149 ILE B N   1 
ATOM   3796 C  CA  . ILE B 1 191 ? 24.42635 -2.10424  -56.19259  1.000 55.51099  ? 149 ILE B CA  1 
ATOM   3797 C  C   . ILE B 1 191 ? 25.28457 -1.16899  -57.05278  1.000 56.39105  ? 149 ILE B C   1 
ATOM   3798 O  O   . ILE B 1 191 ? 25.00884 0.03256   -57.18217  1.000 61.56228  ? 149 ILE B O   1 
ATOM   3799 C  CB  . ILE B 1 191 ? 23.15393 -2.58898  -56.91619  1.000 50.07358  ? 149 ILE B CB  1 
ATOM   3800 C  CG1 . ILE B 1 191 ? 23.47850 -3.51590  -58.09408  1.000 49.57252  ? 149 ILE B CG1 1 
ATOM   3801 C  CG2 . ILE B 1 191 ? 22.26487 -1.40585  -57.33653  1.000 59.69332  ? 149 ILE B CG2 1 
ATOM   3802 C  CD1 . ILE B 1 191 ? 24.54902 -4.57332  -57.79105  1.000 47.26625  ? 149 ILE B CD1 1 
ATOM   3803 N  N   . LYS B 1 192 ? 26.35113 -1.72441  -57.63054  1.000 54.45679  ? 150 LYS B N   1 
ATOM   3804 C  CA  . LYS B 1 192 ? 27.29144 -0.96586  -58.45737  1.000 56.37747  ? 150 LYS B CA  1 
ATOM   3805 C  C   . LYS B 1 192 ? 26.63204 -0.43284  -59.73320  1.000 47.88217  ? 150 LYS B C   1 
ATOM   3806 O  O   . LYS B 1 192 ? 25.72256 -1.06272  -60.28285  1.000 46.42542  ? 150 LYS B O   1 
ATOM   3807 C  CB  . LYS B 1 192 ? 28.46428 -1.86256  -58.84183  1.000 48.95495  ? 150 LYS B CB  1 
ATOM   3808 C  CG  . LYS B 1 192 ? 28.01367 -3.15652  -59.54824  1.000 43.92045  ? 150 LYS B CG  1 
ATOM   3809 C  CD  . LYS B 1 192 ? 29.13286 -4.21252  -59.57557  1.000 57.89232  ? 150 LYS B CD  1 
ATOM   3810 C  CE  . LYS B 1 192 ? 28.66362 -5.58678  -60.11445  1.000 52.52775  ? 150 LYS B CE  1 
ATOM   3811 N  NZ  . LYS B 1 192 ? 29.84439 -6.48434  -60.47534  1.000 51.33564  ? 150 LYS B NZ  1 
ATOM   3812 N  N   . ASP B 1 193 ? 27.14438 0.70513   -60.25391  1.000 47.28974  ? 151 ASP B N   1 
ATOM   3813 C  CA  . ASP B 1 193 ? 26.59968 1.24330   -61.50992  1.000 41.51273  ? 151 ASP B CA  1 
ATOM   3814 C  C   . ASP B 1 193 ? 26.73198 0.24212   -62.64245  1.000 37.23949  ? 151 ASP B C   1 
ATOM   3815 O  O   . ASP B 1 193 ? 25.76852 -0.00391  -63.37938  1.000 37.12122  ? 151 ASP B O   1 
ATOM   3816 C  CB  . ASP B 1 193 ? 27.26818 2.55495   -61.91443  1.000 37.35948  ? 151 ASP B CB  1 
ATOM   3817 C  CG  . ASP B 1 193 ? 26.54843 3.77226   -61.36914  1.000 62.00830  ? 151 ASP B CG  1 
ATOM   3818 O  OD1 . ASP B 1 193 ? 27.16758 4.87487   -61.36058  1.000 63.61908  ? 151 ASP B OD1 1 
ATOM   3819 O  OD2 . ASP B 1 193 ? 25.33030 3.64756   -61.06248  1.000 61.39472  ? 151 ASP B OD2 1 
ATOM   3820 N  N   . ARG B 1 194 ? 27.89012 -0.39358  -62.75768  1.000 29.15331  ? 152 ARG B N   1 
ATOM   3821 C  CA  . ARG B 1 194 ? 28.13735 -1.33544  -63.83801  1.000 24.61962  ? 152 ARG B CA  1 
ATOM   3822 C  C   . ARG B 1 194 ? 27.80009 -2.74854  -63.34983  1.000 37.07807  ? 152 ARG B C   1 
ATOM   3823 O  O   . ARG B 1 194 ? 28.65964 -3.59549  -63.08602  1.000 33.43866  ? 152 ARG B O   1 
ATOM   3824 C  CB  . ARG B 1 194 ? 29.57608 -1.21388  -64.32226  1.000 26.52046  ? 152 ARG B CB  1 
ATOM   3825 C  CG  . ARG B 1 194 ? 29.88246 0.11561   -65.01022  1.000 23.79984  ? 152 ARG B CG  1 
ATOM   3826 C  CD  . ARG B 1 194 ? 31.29808 0.09778   -65.53312  1.000 21.79848  ? 152 ARG B CD  1 
ATOM   3827 N  NE  . ARG B 1 194 ? 32.21614 -0.19633  -64.44630  1.000 22.12958  ? 152 ARG B NE  1 
ATOM   3828 C  CZ  . ARG B 1 194 ? 32.65334 0.68767   -63.56498  1.000 27.35092  ? 152 ARG B CZ  1 
ATOM   3829 N  NH1 . ARG B 1 194 ? 32.31800 1.97433   -63.64540  1.000 23.82586  ? 152 ARG B NH1 1 
ATOM   3830 N  NH2 . ARG B 1 194 ? 33.46051 0.27792   -62.58866  1.000 24.80125  ? 152 ARG B NH2 1 
ATOM   3831 N  N   . SER B 1 195 ? 26.52055 -2.99191  -63.25538  1.000 27.31835  ? 153 SER B N   1 
ATOM   3832 C  CA  . SER B 1 195 ? 25.95014 -4.22345  -62.74144  1.000 20.34289  ? 153 SER B CA  1 
ATOM   3833 C  C   . SER B 1 195 ? 25.41436 -5.06832  -63.88504  1.000 23.72067  ? 153 SER B C   1 
ATOM   3834 O  O   . SER B 1 195 ? 25.02846 -4.53350  -64.93403  1.000 19.33524  ? 153 SER B O   1 
ATOM   3835 C  CB  . SER B 1 195 ? 24.80067 -3.88784  -61.79905  1.000 26.27277  ? 153 SER B CB  1 
ATOM   3836 O  OG  . SER B 1 195 ? 23.65758 -3.67026  -62.60797  1.000 24.25787  ? 153 SER B OG  1 
ATOM   3837 N  N   . PRO B 1 196 ? 25.30599 -6.39824  -63.69911  1.000 17.93228  ? 154 PRO B N   1 
ATOM   3838 C  CA  . PRO B 1 196 ? 24.66775 -7.22995  -64.72870  1.000 19.76637  ? 154 PRO B CA  1 
ATOM   3839 C  C   . PRO B 1 196 ? 23.14984 -6.96344  -64.91289  1.000 17.85915  ? 154 PRO B C   1 
ATOM   3840 O  O   . PRO B 1 196 ? 22.58639 -7.43901  -65.91061  1.000 17.22836  ? 154 PRO B O   1 
ATOM   3841 C  CB  . PRO B 1 196 ? 24.93162 -8.66505  -64.23095  1.000 18.39548  ? 154 PRO B CB  1 
ATOM   3842 C  CG  . PRO B 1 196 ? 24.99407 -8.54788  -62.77532  1.000 19.16435  ? 154 PRO B CG  1 
ATOM   3843 C  CD  . PRO B 1 196 ? 25.64100 -7.19219  -62.50150  1.000 20.55099  ? 154 PRO B CD  1 
ATOM   3844 N  N   . TYR B 1 197 ? 22.47987 -6.23410  -64.00688  1.000 18.65856  ? 155 TYR B N   1 
ATOM   3845 C  CA  . TYR B 1 197 ? 21.04873 -5.94085  -64.18381  1.000 23.89353  ? 155 TYR B CA  1 
ATOM   3846 C  C   . TYR B 1 197 ? 20.76953 -4.75991  -65.10193  1.000 24.49356  ? 155 TYR B C   1 
ATOM   3847 O  O   . TYR B 1 197 ? 19.61904 -4.57149  -65.49877  1.000 20.68933  ? 155 TYR B O   1 
ATOM   3848 C  CB  . TYR B 1 197 ? 20.38192 -5.65004  -62.84072  1.000 16.67187  ? 155 TYR B CB  1 
ATOM   3849 C  CG  . TYR B 1 197 ? 20.91463 -6.53966  -61.77088  1.000 19.72140  ? 155 TYR B CG  1 
ATOM   3850 C  CD1 . TYR B 1 197 ? 20.75783 -7.91795  -61.85719  1.000 19.27683  ? 155 TYR B CD1 1 
ATOM   3851 C  CD2 . TYR B 1 197 ? 21.60948 -6.02052  -60.69117  1.000 19.63194  ? 155 TYR B CD2 1 
ATOM   3852 C  CE1 . TYR B 1 197 ? 21.26062 -8.75200  -60.89974  1.000 18.81980  ? 155 TYR B CE1 1 
ATOM   3853 C  CE2 . TYR B 1 197 ? 22.11503 -6.85114  -59.71417  1.000 24.58243  ? 155 TYR B CE2 1 
ATOM   3854 C  CZ  . TYR B 1 197 ? 21.94149 -8.21945  -59.83004  1.000 29.26965  ? 155 TYR B CZ  1 
ATOM   3855 O  OH  . TYR B 1 197 ? 22.44868 -9.06553  -58.86981  1.000 23.05240  ? 155 TYR B OH  1 
ATOM   3856 N  N   . ARG B 1 198 ? 21.76763 -3.95979  -65.44893  1.000 17.61405  ? 156 ARG B N   1 
ATOM   3857 C  CA  . ARG B 1 198 ? 21.50378 -2.70652  -66.14840  1.000 17.39334  ? 156 ARG B CA  1 
ATOM   3858 C  C   . ARG B 1 198 ? 21.09724 -2.94625  -67.59499  1.000 15.62813  ? 156 ARG B C   1 
ATOM   3859 O  O   . ARG B 1 198 ? 21.71483 -3.75006  -68.31006  1.000 15.00578  ? 156 ARG B O   1 
ATOM   3860 C  CB  . ARG B 1 198 ? 22.75055 -1.80933  -66.11575  1.000 22.35815  ? 156 ARG B CB  1 
ATOM   3861 C  CG  . ARG B 1 198 ? 22.39952 -0.38720  -66.35125  1.000 26.51290  ? 156 ARG B CG  1 
ATOM   3862 C  CD  . ARG B 1 198 ? 22.09948 0.32316   -65.05061  1.000 38.92600  ? 156 ARG B CD  1 
ATOM   3863 N  NE  . ARG B 1 198 ? 23.23696 1.11857   -64.62717  1.000 37.28083  ? 156 ARG B NE  1 
ATOM   3864 C  CZ  . ARG B 1 198 ? 23.49621 2.36145   -65.01936  1.000 45.95444  ? 156 ARG B CZ  1 
ATOM   3865 N  NH1 . ARG B 1 198 ? 22.68005 3.02659   -65.80727  1.000 52.44307  ? 156 ARG B NH1 1 
ATOM   3866 N  NH2 . ARG B 1 198 ? 24.62865 2.93815   -64.64023  1.000 42.18195  ? 156 ARG B NH2 1 
ATOM   3867 N  N   . THR B 1 199 ? 20.05947 -2.23946  -68.04337  1.000 18.11157  ? 157 THR B N   1 
ATOM   3868 C  CA  . THR B 1 199 ? 19.58390 -2.40565  -69.41532  1.000 15.58079  ? 157 THR B CA  1 
ATOM   3869 C  C   . THR B 1 199 ? 19.33857 -1.05744  -70.06935  1.000 13.69964  ? 157 THR B C   1 
ATOM   3870 O  O   . THR B 1 199 ? 19.00111 -0.09539  -69.40214  1.000 17.82020  ? 157 THR B O   1 
ATOM   3871 C  CB  . THR B 1 199 ? 18.23909 -3.25138  -69.50886  1.000 19.29466  ? 157 THR B CB  1 
ATOM   3872 O  OG1 . THR B 1 199 ? 17.16775 -2.58386  -68.80358  1.000 19.47135  ? 157 THR B OG1 1 
ATOM   3873 C  CG2 . THR B 1 199 ? 18.42281 -4.69461  -69.02359  1.000 20.26749  ? 157 THR B CG2 1 
ATOM   3874 N  N   . LEU B 1 200 ? 19.52954 -1.00938  -71.38955  1.000 14.06559  ? 158 LEU B N   1 
ATOM   3875 C  CA  . LEU B 1 200 ? 19.10789 0.09814   -72.22267  1.000 16.82536  ? 158 LEU B CA  1 
ATOM   3876 C  C   . LEU B 1 200 ? 17.66500 -0.13578  -72.66212  1.000 19.60477  ? 158 LEU B C   1 
ATOM   3877 O  O   . LEU B 1 200 ? 17.35994 -1.15534  -73.30631  1.000 15.91709  ? 158 LEU B O   1 
ATOM   3878 C  CB  . LEU B 1 200 ? 20.01416 0.21415   -73.44580  1.000 18.75214  ? 158 LEU B CB  1 
ATOM   3879 C  CG  . LEU B 1 200 ? 19.65949 1.36120   -74.38372  1.000 19.54995  ? 158 LEU B CG  1 
ATOM   3880 C  CD1 . LEU B 1 200 ? 19.86831 2.71914   -73.68088  1.000 18.55286  ? 158 LEU B CD1 1 
ATOM   3881 C  CD2 . LEU B 1 200 ? 20.49657 1.27259   -75.65187  1.000 11.88149  ? 158 LEU B CD2 1 
ATOM   3882 N  N   . MET B 1 201 ? 16.78139 0.81435   -72.33067  1.000 14.76764  ? 159 MET B N   1 
ATOM   3883 C  CA  . MET B 1 201 ? 15.37985 0.79276   -72.74266  1.000 12.71515  ? 159 MET B CA  1 
ATOM   3884 C  C   . MET B 1 201 ? 15.11903 2.12194   -73.42005  1.000 19.20884  ? 159 MET B C   1 
ATOM   3885 O  O   . MET B 1 201 ? 15.97999 3.00065   -73.41828  1.000 17.62512  ? 159 MET B O   1 
ATOM   3886 C  CB  . MET B 1 201 ? 14.41905 0.71896   -71.56366  1.000 16.47738  ? 159 MET B CB  1 
ATOM   3887 C  CG  . MET B 1 201 ? 14.88329 -0.16159  -70.44096  1.000 28.77426  ? 159 MET B CG  1 
ATOM   3888 S  SD  . MET B 1 201 ? 14.46908 -1.83632  -70.71006  1.000 32.70610  ? 159 MET B SD  1 
ATOM   3889 C  CE  . MET B 1 201 ? 12.73355 -1.87130  -70.27714  1.000 18.45306  ? 159 MET B CE  1 
ATOM   3890 N  N   . SER B 1 202 ? 13.92851 2.26822   -74.00175  1.000 14.74892  ? 160 SER B N   1 
ATOM   3891 C  CA  . SER B 1 202 ? 13.51782 3.55524   -74.54043  1.000 16.04799  ? 160 SER B CA  1 
ATOM   3892 C  C   . SER B 1 202 ? 12.00123 3.69700   -74.46974  1.000 22.29894  ? 160 SER B C   1 
ATOM   3893 O  O   . SER B 1 202 ? 11.25978 2.70918   -74.49281  1.000 19.50873  ? 160 SER B O   1 
ATOM   3894 C  CB  . SER B 1 202 ? 13.97868 3.76854   -75.97620  1.000 18.43698  ? 160 SER B CB  1 
ATOM   3895 O  OG  . SER B 1 202 ? 13.29542 2.89618   -76.85857  1.000 19.47648  ? 160 SER B OG  1 
ATOM   3896 N  N   . CYS B 1 203 ? 11.54224 4.94744   -74.40004  1.000 16.96499  ? 161 CYS B N   1 
ATOM   3897 C  CA  . CYS B 1 203 ? 10.09759 5.17900   -74.39746  1.000 15.07725  ? 161 CYS B CA  1 
ATOM   3898 C  C   . CYS B 1 203 ? 9.86096  6.47361   -75.16651  1.000 19.13899  ? 161 CYS B C   1 
ATOM   3899 O  O   . CYS B 1 203 ? 10.83347 7.18138   -75.50361  1.000 17.41225  ? 161 CYS B O   1 
ATOM   3900 C  CB  . CYS B 1 203 ? 9.56695  5.25748   -72.97506  1.000 22.55660  ? 161 CYS B CB  1 
ATOM   3901 S  SG  . CYS B 1 203 ? 10.17026 6.72174   -72.11534  1.000 23.05869  ? 161 CYS B SG  1 
ATOM   3902 N  N   . PRO B 1 204 ? 8.62061  6.76890   -75.56081  1.000 24.41296  ? 162 PRO B N   1 
ATOM   3903 C  CA  . PRO B 1 204 ? 8.37027  8.02972   -76.27328  1.000 17.95477  ? 162 PRO B CA  1 
ATOM   3904 C  C   . PRO B 1 204 ? 8.81254  9.23039   -75.43863  1.000 13.44888  ? 162 PRO B C   1 
ATOM   3905 O  O   . PRO B 1 204 ? 8.69415  9.23716   -74.21147  1.000 17.41712  ? 162 PRO B O   1 
ATOM   3906 C  CB  . PRO B 1 204 ? 6.85682  8.01549   -76.49411  1.000 20.30764  ? 162 PRO B CB  1 
ATOM   3907 C  CG  . PRO B 1 204 ? 6.49356  6.52744   -76.51674  1.000 16.81656  ? 162 PRO B CG  1 
ATOM   3908 C  CD  . PRO B 1 204 ? 7.40522  5.91627   -75.47688  1.000 17.52592  ? 162 PRO B CD  1 
ATOM   3909 N  N   . VAL B 1 205 ? 9.33613  10.24534  -76.12162  1.000 19.67667  ? 163 VAL B N   1 
ATOM   3910 C  CA  . VAL B 1 205 ? 9.79139  11.48113  -75.47148  1.000 19.05616  ? 163 VAL B CA  1 
ATOM   3911 C  C   . VAL B 1 205 ? 8.68775  12.08525  -74.58518  1.000 27.11188  ? 163 VAL B C   1 
ATOM   3912 O  O   . VAL B 1 205 ? 7.53403  12.20749  -75.00637  1.000 20.30265  ? 163 VAL B O   1 
ATOM   3913 C  CB  . VAL B 1 205 ? 10.22983 12.47950  -76.56011  1.000 20.79998  ? 163 VAL B CB  1 
ATOM   3914 C  CG1 . VAL B 1 205 ? 10.22843 13.87437  -76.03205  1.000 24.68149  ? 163 VAL B CG1 1 
ATOM   3915 C  CG2 . VAL B 1 205 ? 11.62165 12.15888  -77.07050  1.000 20.65643  ? 163 VAL B CG2 1 
ATOM   3916 N  N   . GLY B 1 206 ? 9.03993  12.48828  -73.35459  1.000 21.76190  ? 164 GLY B N   1 
ATOM   3917 C  CA  . GLY B 1 206 ? 8.08929  13.17071  -72.48690  1.000 17.48736  ? 164 GLY B CA  1 
ATOM   3918 C  C   . GLY B 1 206 ? 7.20244  12.26474  -71.64588  1.000 21.84884  ? 164 GLY B C   1 
ATOM   3919 O  O   . GLY B 1 206 ? 6.41690  12.76647  -70.81387  1.000 20.99687  ? 164 GLY B O   1 
ATOM   3920 N  N   . GLU B 1 207 ? 7.27114  10.95363  -71.85160  1.000 19.16946  ? 165 GLU B N   1 
ATOM   3921 C  CA  . GLU B 1 207 ? 6.52509  10.00884  -71.04235  1.000 22.11587  ? 165 GLU B CA  1 
ATOM   3922 C  C   . GLU B 1 207 ? 7.40507  9.51819   -69.90257  1.000 21.87243  ? 165 GLU B C   1 
ATOM   3923 O  O   . GLU B 1 207 ? 8.62144  9.34308   -70.06225  1.000 19.60904  ? 165 GLU B O   1 
ATOM   3924 C  CB  . GLU B 1 207 ? 6.05294  8.83292   -71.89966  1.000 23.11283  ? 165 GLU B CB  1 
ATOM   3925 C  CG  . GLU B 1 207 ? 5.08613  9.25122   -72.97415  1.000 24.55365  ? 165 GLU B CG  1 
ATOM   3926 C  CD  . GLU B 1 207 ? 4.46643  8.07724   -73.72692  1.000 23.79703  ? 165 GLU B CD  1 
ATOM   3927 O  OE1 . GLU B 1 207 ? 4.50104  6.90954   -73.23566  1.000 24.81316  ? 165 GLU B OE1 1 
ATOM   3928 O  OE2 . GLU B 1 207 ? 3.94708  8.32770   -74.84391  1.000 23.09583  ? 165 GLU B OE2 1 
ATOM   3929 N  N   . ALA B 1 208 ? 6.79212  9.32760   -68.74294  1.000 14.62845  ? 166 ALA B N   1 
ATOM   3930 C  CA  . ALA B 1 208 ? 7.51931  8.71640   -67.64688  1.000 18.13974  ? 166 ALA B CA  1 
ATOM   3931 C  C   . ALA B 1 208 ? 7.96693  7.31367   -68.06314  1.000 19.62319  ? 166 ALA B C   1 
ATOM   3932 O  O   . ALA B 1 208 ? 7.20271  6.58613   -68.73211  1.000 16.08553  ? 166 ALA B O   1 
ATOM   3933 C  CB  . ALA B 1 208 ? 6.65481  8.63531   -66.38912  1.000 19.42072  ? 166 ALA B CB  1 
ATOM   3934 N  N   . PRO B 1 209 ? 9.21961  6.90986   -67.71227  1.000 15.33820  ? 167 PRO B N   1 
ATOM   3935 C  CA  . PRO B 1 209 ? 9.74448  5.61618   -68.17581  1.000 16.28575  ? 167 PRO B CA  1 
ATOM   3936 C  C   . PRO B 1 209 ? 9.23806  4.46591   -67.31442  1.000 18.38041  ? 167 PRO B C   1 
ATOM   3937 O  O   . PRO B 1 209 ? 9.71162  4.19899   -66.19054  1.000 15.96334  ? 167 PRO B O   1 
ATOM   3938 C  CB  . PRO B 1 209 ? 11.27091 5.80491   -68.07264  1.000 21.32789  ? 167 PRO B CB  1 
ATOM   3939 C  CG  . PRO B 1 209 ? 11.45846 6.82413   -66.96157  1.000 13.59556  ? 167 PRO B CG  1 
ATOM   3940 C  CD  . PRO B 1 209 ? 10.26600 7.75935   -67.07361  1.000 14.95744  ? 167 PRO B CD  1 
ATOM   3941 N  N   . SER B 1 210 ? 8.27495  3.77945   -67.82653  1.000 19.58672  ? 168 SER B N   1 
ATOM   3942 C  CA  A SER B 1 210 ? 7.65148  2.71465   -67.06331  0.500 19.33160  ? 168 SER B CA  1 
ATOM   3943 C  CA  B SER B 1 210 ? 7.62198  2.72073   -67.07998  0.500 19.35298  ? 168 SER B CA  1 
ATOM   3944 C  C   . SER B 1 210 ? 7.86650  1.35704   -67.72794  1.000 18.77356  ? 168 SER B C   1 
ATOM   3945 O  O   . SER B 1 210 ? 8.07808  1.26664   -68.94424  1.000 14.71385  ? 168 SER B O   1 
ATOM   3946 C  CB  A SER B 1 210 ? 6.14420  2.98662   -66.89413  0.500 15.65340  ? 168 SER B CB  1 
ATOM   3947 C  CB  B SER B 1 210 ? 6.10693  2.98389   -66.99835  0.500 15.60103  ? 168 SER B CB  1 
ATOM   3948 O  OG  A SER B 1 210 ? 5.40545  2.42140   -67.95186  0.500 14.23979  ? 168 SER B OG  1 
ATOM   3949 O  OG  B SER B 1 210 ? 5.44567  1.97674   -66.25214  0.500 10.14851  ? 168 SER B OG  1 
ATOM   3950 N  N   . PRO B 1 211 ? 7.82028  0.26712   -66.96021  1.000 15.50450  ? 169 PRO B N   1 
ATOM   3951 C  CA  . PRO B 1 211 ? 7.80054  -1.05126  -67.61816  1.000 18.98230  ? 169 PRO B CA  1 
ATOM   3952 C  C   . PRO B 1 211 ? 6.61853  -1.21168  -68.54280  1.000 20.79764  ? 169 PRO B C   1 
ATOM   3953 O  O   . PRO B 1 211 ? 6.64869  -2.12697  -69.36244  1.000 18.84469  ? 169 PRO B O   1 
ATOM   3954 C  CB  . PRO B 1 211 ? 7.73877  -2.05067  -66.45653  1.000 11.66156  ? 169 PRO B CB  1 
ATOM   3955 C  CG  . PRO B 1 211 ? 7.33847  -1.28784  -65.24837  1.000 13.53336  ? 169 PRO B CG  1 
ATOM   3956 C  CD  . PRO B 1 211 ? 7.87582  0.14539   -65.48800  1.000 18.35350  ? 169 PRO B CD  1 
ATOM   3957 N  N   . TYR B 1 212 ? 5.57211  -0.34523  -68.44374  1.000 17.77832  ? 170 TYR B N   1 
ATOM   3958 C  CA  . TYR B 1 212 ? 4.37179  -0.52372  -69.26114  1.000 19.42118  ? 170 TYR B CA  1 
ATOM   3959 C  C   . TYR B 1 212 ? 4.42277  0.25580   -70.55371  1.000 21.40680  ? 170 TYR B C   1 
ATOM   3960 O  O   . TYR B 1 212 ? 3.62697  -0.01378  -71.45407  1.000 21.61328  ? 170 TYR B O   1 
ATOM   3961 C  CB  . TYR B 1 212 ? 3.09837  -0.13881  -68.49220  1.000 14.41136  ? 170 TYR B CB  1 
ATOM   3962 C  CG  . TYR B 1 212 ? 3.09173  -0.68074  -67.07365  1.000 12.14033  ? 170 TYR B CG  1 
ATOM   3963 C  CD1 . TYR B 1 212 ? 3.55210  -1.98635  -66.79650  1.000 15.54044  ? 170 TYR B CD1 1 
ATOM   3964 C  CD2 . TYR B 1 212 ? 2.66747  0.11660   -66.00857  1.000 12.18264  ? 170 TYR B CD2 1 
ATOM   3965 C  CE1 . TYR B 1 212 ? 3.58615  -2.48656  -65.47059  1.000 9.22004   ? 170 TYR B CE1 1 
ATOM   3966 C  CE2 . TYR B 1 212 ? 2.67782  -0.37403  -64.70157  1.000 10.93650  ? 170 TYR B CE2 1 
ATOM   3967 C  CZ  . TYR B 1 212 ? 3.15836  -1.66640  -64.44872  1.000 13.11858  ? 170 TYR B CZ  1 
ATOM   3968 O  OH  . TYR B 1 212 ? 3.20894  -2.11347  -63.14741  1.000 17.78131  ? 170 TYR B OH  1 
ATOM   3969 N  N   . ASN B 1 213 ? 5.31792  1.22415   -70.68189  1.000 15.02764  ? 171 ASN B N   1 
ATOM   3970 C  CA  . ASN B 1 213 ? 5.42395  1.94247   -71.94969  1.000 18.97272  ? 171 ASN B CA  1 
ATOM   3971 C  C   . ASN B 1 213 ? 6.84286  1.91750   -72.52115  1.000 25.53465  ? 171 ASN B C   1 
ATOM   3972 O  O   . ASN B 1 213 ? 7.10730  2.63983   -73.49042  1.000 19.12995  ? 171 ASN B O   1 
ATOM   3973 C  CB  . ASN B 1 213 ? 4.97400  3.40137   -71.78765  1.000 18.24172  ? 171 ASN B CB  1 
ATOM   3974 C  CG  . ASN B 1 213 ? 5.98312  4.21380   -70.95681  1.000 24.36412  ? 171 ASN B CG  1 
ATOM   3975 O  OD1 . ASN B 1 213 ? 6.76196  3.63781   -70.17275  1.000 18.01963  ? 171 ASN B OD1 1 
ATOM   3976 N  ND2 . ASN B 1 213 ? 5.99061  5.53999   -71.13198  1.000 21.27201  ? 171 ASN B ND2 1 
ATOM   3977 N  N   . SER B 1 214 ? 7.78117  1.16575   -71.93017  1.000 17.87691  ? 172 SER B N   1 
ATOM   3978 C  CA  . SER B 1 214 ? 9.17139  1.20682   -72.39270  1.000 21.34982  ? 172 SER B CA  1 
ATOM   3979 C  C   . SER B 1 214 ? 9.53630  -0.06394  -73.14191  1.000 24.08609  ? 172 SER B C   1 
ATOM   3980 O  O   . SER B 1 214 ? 9.20213  -1.17068  -72.71438  1.000 26.01918  ? 172 SER B O   1 
ATOM   3981 C  CB  . SER B 1 214 ? 10.17169 1.38596   -71.24829  1.000 21.50564  ? 172 SER B CB  1 
ATOM   3982 O  OG  . SER B 1 214 ? 9.88359  2.52185   -70.47093  1.000 21.47152  ? 172 SER B OG  1 
ATOM   3983 N  N   . ARG B 1 215 ? 10.26525 0.11317   -74.23202  1.000 19.34603  ? 173 ARG B N   1 
ATOM   3984 C  CA  . ARG B 1 215 ? 10.70894 -0.96351  -75.09093  1.000 27.70986  ? 173 ARG B CA  1 
ATOM   3985 C  C   . ARG B 1 215 ? 12.13382 -1.39072  -74.71275  1.000 24.54985  ? 173 ARG B C   1 
ATOM   3986 O  O   . ARG B 1 215 ? 12.98562 -0.54721  -74.40301  1.000 17.86214  ? 173 ARG B O   1 
ATOM   3987 C  CB  . ARG B 1 215 ? 10.60467 -0.47252  -76.53213  1.000 31.23416  ? 173 ARG B CB  1 
ATOM   3988 C  CG  . ARG B 1 215 ? 11.51044 -1.11251  -77.53701  1.000 34.41107  ? 173 ARG B CG  1 
ATOM   3989 C  CD  . ARG B 1 215 ? 11.20898 -0.48662  -78.89248  1.000 35.38649  ? 173 ARG B CD  1 
ATOM   3990 N  NE  . ARG B 1 215 ? 12.30385 0.35331   -79.35501  1.000 44.37699  ? 173 ARG B NE  1 
ATOM   3991 C  CZ  . ARG B 1 215 ? 12.24848 1.15315   -80.41573  1.000 48.20439  ? 173 ARG B CZ  1 
ATOM   3992 N  NH1 . ARG B 1 215 ? 11.12087 1.30861   -81.10657  1.000 42.26800  ? 173 ARG B NH1 1 
ATOM   3993 N  NH2 . ARG B 1 215 ? 13.34610 1.83677   -80.77323  1.000 40.09225  ? 173 ARG B NH2 1 
ATOM   3994 N  N   . PHE B 1 216 ? 12.38009 -2.70376  -74.69111  1.000 15.58038  ? 174 PHE B N   1 
ATOM   3995 C  CA  . PHE B 1 216 ? 13.70823 -3.19444  -74.34889  1.000 15.36871  ? 174 PHE B CA  1 
ATOM   3996 C  C   . PHE B 1 216 ? 14.63452 -3.01482  -75.53600  1.000 10.55099  ? 174 PHE B C   1 
ATOM   3997 O  O   . PHE B 1 216 ? 14.26447 -3.32149  -76.66735  1.000 22.04065  ? 174 PHE B O   1 
ATOM   3998 C  CB  . PHE B 1 216 ? 13.68622 -4.66452  -73.93915  1.000 20.70730  ? 174 PHE B CB  1 
ATOM   3999 C  CG  . PHE B 1 216 ? 15.05319 -5.22601  -73.70332  1.000 14.07777  ? 174 PHE B CG  1 
ATOM   4000 C  CD1 . PHE B 1 216 ? 15.65088 -5.11362  -72.46056  1.000 14.08691  ? 174 PHE B CD1 1 
ATOM   4001 C  CD2 . PHE B 1 216 ? 15.77133 -5.80915  -74.73859  1.000 19.39476  ? 174 PHE B CD2 1 
ATOM   4002 C  CE1 . PHE B 1 216 ? 16.96309 -5.62811  -72.24542  1.000 19.30802  ? 174 PHE B CE1 1 
ATOM   4003 C  CE2 . PHE B 1 216 ? 17.08325 -6.31938  -74.53872  1.000 14.57524  ? 174 PHE B CE2 1 
ATOM   4004 C  CZ  . PHE B 1 216 ? 17.66390 -6.22461  -73.29658  1.000 17.85694  ? 174 PHE B CZ  1 
ATOM   4005 N  N   . GLU B 1 217 ? 15.84320 -2.52158  -75.28302  1.000 14.73959  ? 175 GLU B N   1 
ATOM   4006 C  CA  . GLU B 1 217 ? 16.83299 -2.35741  -76.34472  1.000 15.40992  ? 175 GLU B CA  1 
ATOM   4007 C  C   . GLU B 1 217 ? 18.04090 -3.27899  -76.21343  1.000 21.38717  ? 175 GLU B C   1 
ATOM   4008 O  O   . GLU B 1 217 ? 18.45667 -3.92817  -77.18471  1.000 17.97115  ? 175 GLU B O   1 
ATOM   4009 C  CB  . GLU B 1 217 ? 17.32334 -0.89470  -76.36902  1.000 19.09154  ? 175 GLU B CB  1 
ATOM   4010 C  CG  . GLU B 1 217 ? 16.20271 0.16507   -76.54442  1.000 16.92769  ? 175 GLU B CG  1 
ATOM   4011 C  CD  . GLU B 1 217 ? 15.61458 0.17174   -77.93108  1.000 16.31140  ? 175 GLU B CD  1 
ATOM   4012 O  OE1 . GLU B 1 217 ? 16.13898 -0.53048  -78.81833  1.000 24.19001  ? 175 GLU B OE1 1 
ATOM   4013 O  OE2 . GLU B 1 217 ? 14.61630 0.88845   -78.15370  1.000 21.26112  ? 175 GLU B OE2 1 
ATOM   4014 N  N   . SER B 1 218 ? 18.66750 -3.31319  -75.04237  1.000 14.81088  ? 176 SER B N   1 
ATOM   4015 C  CA  . SER B 1 218 ? 19.92994 -4.02278  -74.96218  1.000 22.77321  ? 176 SER B CA  1 
ATOM   4016 C  C   . SER B 1 218 ? 20.30502 -4.14411  -73.50464  1.000 13.63739  ? 176 SER B C   1 
ATOM   4017 O  O   . SER B 1 218 ? 19.90729 -3.31925  -72.68825  1.000 13.53151  ? 176 SER B O   1 
ATOM   4018 C  CB  . SER B 1 218 ? 21.04270 -3.29728  -75.73734  1.000 25.28332  ? 176 SER B CB  1 
ATOM   4019 O  OG  . SER B 1 218 ? 21.83800 -4.25525  -76.44344  1.000 34.92187  ? 176 SER B OG  1 
ATOM   4020 N  N   . VAL B 1 219 ? 21.06072 -5.17703  -73.18650  1.000 13.29339  ? 177 VAL B N   1 
ATOM   4021 C  CA  . VAL B 1 219 ? 21.70154 -5.23412  -71.87898  1.000 14.56238  ? 177 VAL B CA  1 
ATOM   4022 C  C   . VAL B 1 219 ? 22.92851 -4.32354  -71.93725  1.000 13.89915  ? 177 VAL B C   1 
ATOM   4023 O  O   . VAL B 1 219 ? 23.78183 -4.45518  -72.82599  1.000 16.80553  ? 177 VAL B O   1 
ATOM   4024 C  CB  . VAL B 1 219 ? 22.05799 -6.68339  -71.49947  1.000 12.57433  ? 177 VAL B CB  1 
ATOM   4025 C  CG1 . VAL B 1 219 ? 22.53446 -6.74747  -70.06002  1.000 11.38070  ? 177 VAL B CG1 1 
ATOM   4026 C  CG2 . VAL B 1 219 ? 20.81033 -7.61985  -71.64755  1.000 13.30295  ? 177 VAL B CG2 1 
ATOM   4027 N  N   . ALA B 1 220 ? 23.00832 -3.38724  -71.01046  1.000 12.23841  ? 178 ALA B N   1 
ATOM   4028 C  CA  . ALA B 1 220 ? 23.96414 -2.30060  -71.16545  1.000 15.69349  ? 178 ALA B CA  1 
ATOM   4029 C  C   . ALA B 1 220 ? 24.12415 -1.52217  -69.88061  1.000 19.99589  ? 178 ALA B C   1 
ATOM   4030 O  O   . ALA B 1 220 ? 23.11904 -1.08560  -69.30482  1.000 18.86760  ? 178 ALA B O   1 
ATOM   4031 C  CB  . ALA B 1 220 ? 23.51055 -1.35788  -72.26895  1.000 13.37260  ? 178 ALA B CB  1 
ATOM   4032 N  N   . TRP B 1 221 ? 25.36578 -1.29204  -69.44595  1.000 17.30855  ? 179 TRP B N   1 
ATOM   4033 C  CA  . TRP B 1 221 ? 25.61972 -0.24649  -68.46607  1.000 17.64019  ? 179 TRP B CA  1 
ATOM   4034 C  C   . TRP B 1 221 ? 26.32511 0.96330   -69.07797  1.000 17.28168  ? 179 TRP B C   1 
ATOM   4035 O  O   . TRP B 1 221 ? 26.68162 1.89810   -68.36007  1.000 12.98958  ? 179 TRP B O   1 
ATOM   4036 C  CB  . TRP B 1 221 ? 26.38914 -0.78385  -67.25646  1.000 18.15803  ? 179 TRP B CB  1 
ATOM   4037 C  CG  . TRP B 1 221 ? 27.56528 -1.73964  -67.51981  1.000 21.96764  ? 179 TRP B CG  1 
ATOM   4038 C  CD1 . TRP B 1 221 ? 27.61661 -3.07938  -67.20583  1.000 24.13923  ? 179 TRP B CD1 1 
ATOM   4039 C  CD2 . TRP B 1 221 ? 28.84480 -1.41652  -68.09936  1.000 20.84036  ? 179 TRP B CD2 1 
ATOM   4040 N  NE1 . TRP B 1 221 ? 28.83739 -3.60487  -67.55918  1.000 23.70478  ? 179 TRP B NE1 1 
ATOM   4041 C  CE2 . TRP B 1 221 ? 29.61231 -2.61158  -68.11307  1.000 26.32615  ? 179 TRP B CE2 1 
ATOM   4042 C  CE3 . TRP B 1 221 ? 29.41520 -0.24074  -68.60888  1.000 16.63379  ? 179 TRP B CE3 1 
ATOM   4043 C  CZ2 . TRP B 1 221 ? 30.92937 -2.66089  -68.62219  1.000 19.90840  ? 179 TRP B CZ2 1 
ATOM   4044 C  CZ3 . TRP B 1 221 ? 30.71773 -0.29417  -69.13103  1.000 20.87666  ? 179 TRP B CZ3 1 
ATOM   4045 C  CH2 . TRP B 1 221 ? 31.45835 -1.50160  -69.12585  1.000 22.70475  ? 179 TRP B CH2 1 
ATOM   4046 N  N   . SER B 1 222 ? 26.51135 0.97314   -70.38627  1.000 14.14018  ? 180 SER B N   1 
ATOM   4047 C  CA  . SER B 1 222 ? 26.95612 2.14235   -71.12128  1.000 18.94975  ? 180 SER B CA  1 
ATOM   4048 C  C   . SER B 1 222 ? 26.41528 1.94018   -72.52320  1.000 19.61081  ? 180 SER B C   1 
ATOM   4049 O  O   . SER B 1 222 ? 26.38359 0.81054   -73.02370  1.000 13.27795  ? 180 SER B O   1 
ATOM   4050 C  CB  . SER B 1 222 ? 28.49296 2.28494   -71.10840  1.000 21.20674  ? 180 SER B CB  1 
ATOM   4051 O  OG  . SER B 1 222 ? 28.92150 3.36698   -71.90619  1.000 15.47401  ? 180 SER B OG  1 
ATOM   4052 N  N   . ALA B 1 223 ? 25.94665 3.00857   -73.14974  1.000 15.03857  ? 181 ALA B N   1 
ATOM   4053 C  CA  . ALA B 1 223 ? 25.20233 2.79044   -74.37837  1.000 18.06958  ? 181 ALA B CA  1 
ATOM   4054 C  C   . ALA B 1 223 ? 25.26054 3.99318   -75.29351  1.000 22.50360  ? 181 ALA B C   1 
ATOM   4055 O  O   . ALA B 1 223 ? 25.64640 5.10167   -74.90006  1.000 17.49472  ? 181 ALA B O   1 
ATOM   4056 C  CB  . ALA B 1 223 ? 23.71610 2.45469   -74.10337  1.000 14.27733  ? 181 ALA B CB  1 
ATOM   4057 N  N   . SER B 1 224 ? 24.88806 3.72692   -76.54070  1.000 21.01853  ? 182 SER B N   1 
ATOM   4058 C  CA  . SER B 1 224 ? 24.64212 4.73445   -77.55473  1.000 19.66389  ? 182 SER B CA  1 
ATOM   4059 C  C   . SER B 1 224 ? 23.50727 4.21552   -78.41487  1.000 19.26508  ? 182 SER B C   1 
ATOM   4060 O  O   . SER B 1 224 ? 23.25582 3.00216   -78.45738  1.000 19.50692  ? 182 SER B O   1 
ATOM   4061 C  CB  . SER B 1 224 ? 25.88646 4.98783   -78.41476  1.000 21.80124  ? 182 SER B CB  1 
ATOM   4062 O  OG  . SER B 1 224 ? 25.57317 5.97124   -79.38408  1.000 27.79356  ? 182 SER B OG  1 
ATOM   4063 N  N   . ALA B 1 225 ? 22.83091 5.12657   -79.11584  1.000 17.24929  ? 183 ALA B N   1 
ATOM   4064 C  CA  . ALA B 1 225 ? 21.74345 4.73632   -80.01751  1.000 19.48960  ? 183 ALA B CA  1 
ATOM   4065 C  C   . ALA B 1 225 ? 21.50247 5.84502   -81.01588  1.000 22.62818  ? 183 ALA B C   1 
ATOM   4066 O  O   . ALA B 1 225 ? 21.65130 7.02056   -80.68382  1.000 21.39077  ? 183 ALA B O   1 
ATOM   4067 C  CB  . ALA B 1 225 ? 20.43290 4.43318   -79.27583  1.000 19.79765  ? 183 ALA B CB  1 
ATOM   4068 N  N   . CYS B 1 226 ? 21.11308 5.46663   -82.23572  1.000 18.91448  ? 184 CYS B N   1 
ATOM   4069 C  CA  . CYS B 1 226 ? 20.78348 6.47007   -83.24954  1.000 19.02342  ? 184 CYS B CA  1 
ATOM   4070 C  C   . CYS B 1 226 ? 20.08599 5.76728   -84.41073  1.000 23.36561  ? 184 CYS B C   1 
ATOM   4071 O  O   . CYS B 1 226 ? 20.03146 4.54612   -84.46136  1.000 22.76122  ? 184 CYS B O   1 
ATOM   4072 C  CB  . CYS B 1 226 ? 22.02389 7.24028   -83.71060  1.000 20.22529  ? 184 CYS B CB  1 
ATOM   4073 S  SG  . CYS B 1 226 ? 23.37625 6.15684   -84.23981  1.000 23.88703  ? 184 CYS B SG  1 
ATOM   4074 N  N   . HIS B 1 227 ? 19.49831 6.55083   -85.31071  1.000 16.27462  ? 185 HIS B N   1 
ATOM   4075 C  CA  . HIS B 1 227 ? 18.67805 6.03933   -86.39873  1.000 20.40157  ? 185 HIS B CA  1 
ATOM   4076 C  C   . HIS B 1 227 ? 19.22722 6.55400   -87.72306  1.000 25.82914  ? 185 HIS B C   1 
ATOM   4077 O  O   . HIS B 1 227 ? 19.51723 7.74883   -87.85539  1.000 23.94069  ? 185 HIS B O   1 
ATOM   4078 C  CB  . HIS B 1 227 ? 17.21410 6.47280   -86.20943  1.000 16.55075  ? 185 HIS B CB  1 
ATOM   4079 C  CG  . HIS B 1 227 ? 16.23361 5.70148   -87.03314  1.000 22.45569  ? 185 HIS B CG  1 
ATOM   4080 N  ND1 . HIS B 1 227 ? 16.09552 5.88090   -88.39303  1.000 23.64533  ? 185 HIS B ND1 1 
ATOM   4081 C  CD2 . HIS B 1 227 ? 15.32559 4.75418   -86.68160  1.000 25.63297  ? 185 HIS B CD2 1 
ATOM   4082 C  CE1 . HIS B 1 227 ? 15.14705 5.07573   -88.84292  1.000 28.87943  ? 185 HIS B CE1 1 
ATOM   4083 N  NE2 . HIS B 1 227 ? 14.67364 4.37406   -87.82659  1.000 19.95618  ? 185 HIS B NE2 1 
ATOM   4084 N  N   . ASP B 1 228 ? 19.39420 5.66292   -88.70110  1.000 22.24093  ? 186 ASP B N   1 
ATOM   4085 C  CA  . ASP B 1 228 ? 20.05103 6.07005   -89.93303  1.000 25.30218  ? 186 ASP B CA  1 
ATOM   4086 C  C   . ASP B 1 228 ? 19.06265 6.46239   -91.01385  1.000 20.97046  ? 186 ASP B C   1 
ATOM   4087 O  O   . ASP B 1 228 ? 19.46202 6.66960   -92.15951  1.000 22.83944  ? 186 ASP B O   1 
ATOM   4088 C  CB  . ASP B 1 228 ? 20.98307 4.96052   -90.44951  1.000 28.45923  ? 186 ASP B CB  1 
ATOM   4089 C  CG  . ASP B 1 228 ? 20.22423 3.70865   -90.89576  1.000 33.14973  ? 186 ASP B CG  1 
ATOM   4090 O  OD1 . ASP B 1 228 ? 18.98399 3.65448   -90.68824  1.000 22.81749  ? 186 ASP B OD1 1 
ATOM   4091 O  OD2 . ASP B 1 228 ? 20.88049 2.77939   -91.44697  1.000 31.39275  ? 186 ASP B OD2 1 
ATOM   4092 N  N   . GLY B 1 229 ? 17.79202 6.56029   -90.68624  1.000 22.85877  ? 187 GLY B N   1 
ATOM   4093 C  CA  . GLY B 1 229 ? 16.76233 6.75428   -91.67263  1.000 23.26167  ? 187 GLY B CA  1 
ATOM   4094 C  C   . GLY B 1 229 ? 15.98450 5.50123   -91.97130  1.000 30.47253  ? 187 GLY B C   1 
ATOM   4095 O  O   . GLY B 1 229 ? 14.83593 5.57857   -92.42653  1.000 29.10316  ? 187 GLY B O   1 
ATOM   4096 N  N   . ILE B 1 230 ? 16.57236 4.34917   -91.66783  1.000 24.56768  ? 188 ILE B N   1 
ATOM   4097 C  CA  . ILE B 1 230 ? 15.99701 3.05398   -91.99042  1.000 26.45758  ? 188 ILE B CA  1 
ATOM   4098 C  C   . ILE B 1 230 ? 15.66543 2.25339   -90.73483  1.000 26.41580  ? 188 ILE B C   1 
ATOM   4099 O  O   . ILE B 1 230 ? 14.50972 1.88570   -90.51803  1.000 24.60253  ? 188 ILE B O   1 
ATOM   4100 C  CB  . ILE B 1 230 ? 16.92145 2.26519   -92.93404  1.000 32.93353  ? 188 ILE B CB  1 
ATOM   4101 C  CG1 . ILE B 1 230 ? 16.94155 3.00924   -94.28495  1.000 29.97333  ? 188 ILE B CG1 1 
ATOM   4102 C  CG2 . ILE B 1 230 ? 16.49774 0.78134   -93.05684  1.000 28.87769  ? 188 ILE B CG2 1 
ATOM   4103 C  CD1 . ILE B 1 230 ? 17.85874 2.39250   -95.29409  1.000 40.83879  ? 188 ILE B CD1 1 
ATOM   4104 N  N   . SER B 1 231 ? 16.64819 2.03856   -89.85509  1.000 19.73426  ? 189 SER B N   1 
ATOM   4105 C  CA  . SER B 1 231 ? 16.37148 1.30647   -88.62596  1.000 18.19790  ? 189 SER B CA  1 
ATOM   4106 C  C   . SER B 1 231 ? 17.17773 1.87824   -87.47272  1.000 24.43239  ? 189 SER B C   1 
ATOM   4107 O  O   . SER B 1 231 ? 18.13572 2.62573   -87.67445  1.000 18.60160  ? 189 SER B O   1 
ATOM   4108 C  CB  . SER B 1 231 ? 16.68574 -0.19175  -88.77389  1.000 24.67027  ? 189 SER B CB  1 
ATOM   4109 O  OG  . SER B 1 231 ? 15.98909 -0.74695  -89.87001  1.000 24.39453  ? 189 SER B OG  1 
ATOM   4110 N  N   . TRP B 1 232 ? 16.77262 1.50939   -86.25173  1.000 16.65650  ? 190 TRP B N   1 
ATOM   4111 C  CA  . TRP B 1 232 ? 17.52119 1.88046   -85.05637  1.000 20.07116  ? 190 TRP B CA  1 
ATOM   4112 C  C   . TRP B 1 232 ? 18.80789 1.08095   -84.93005  1.000 25.95351  ? 190 TRP B C   1 
ATOM   4113 O  O   . TRP B 1 232 ? 18.79571 -0.15856  -85.02640  1.000 20.52558  ? 190 TRP B O   1 
ATOM   4114 C  CB  . TRP B 1 232 ? 16.68187 1.63200   -83.81415  1.000 15.96810  ? 190 TRP B CB  1 
ATOM   4115 C  CG  . TRP B 1 232 ? 15.68228 2.67312   -83.65154  1.000 22.87816  ? 190 TRP B CG  1 
ATOM   4116 C  CD1 . TRP B 1 232 ? 14.34339 2.58467   -83.92895  1.000 22.25232  ? 190 TRP B CD1 1 
ATOM   4117 C  CD2 . TRP B 1 232 ? 15.92961 4.02035   -83.24191  1.000 18.42373  ? 190 TRP B CD2 1 
ATOM   4118 N  NE1 . TRP B 1 232 ? 13.73516 3.80104   -83.67143  1.000 21.92264  ? 190 TRP B NE1 1 
ATOM   4119 C  CE2 . TRP B 1 232 ? 14.68829 4.69552   -83.24841  1.000 21.17957  ? 190 TRP B CE2 1 
ATOM   4120 C  CE3 . TRP B 1 232 ? 17.07228 4.71167   -82.84958  1.000 17.75398  ? 190 TRP B CE3 1 
ATOM   4121 C  CZ2 . TRP B 1 232 ? 14.56586 6.03144   -82.87696  1.000 22.56969  ? 190 TRP B CZ2 1 
ATOM   4122 C  CZ3 . TRP B 1 232 ? 16.95491 6.03900   -82.48087  1.000 22.32672  ? 190 TRP B CZ3 1 
ATOM   4123 C  CH2 . TRP B 1 232 ? 15.71080 6.69040   -82.50876  1.000 18.38144  ? 190 TRP B CH2 1 
ATOM   4124 N  N   . LEU B 1 233 ? 19.90979 1.79320   -84.68751  1.000 21.29670  ? 191 LEU B N   1 
ATOM   4125 C  CA  . LEU B 1 233 ? 21.18379 1.21622   -84.26499  1.000 19.40861  ? 191 LEU B CA  1 
ATOM   4126 C  C   . LEU B 1 233 ? 21.30906 1.37629   -82.75083  1.000 19.90736  ? 191 LEU B C   1 
ATOM   4127 O  O   . LEU B 1 233 ? 21.11091 2.46831   -82.22421  1.000 15.87209  ? 191 LEU B O   1 
ATOM   4128 C  CB  . LEU B 1 233 ? 22.36709 1.90209   -84.96698  1.000 20.56521  ? 191 LEU B CB  1 
ATOM   4129 C  CG  . LEU B 1 233 ? 23.80176 1.47431   -84.54458  1.000 19.37456  ? 191 LEU B CG  1 
ATOM   4130 C  CD1 . LEU B 1 233 ? 24.10996 0.09787   -85.03469  1.000 14.22380  ? 191 LEU B CD1 1 
ATOM   4131 C  CD2 . LEU B 1 233 ? 24.92555 2.46262   -85.02270  1.000 16.22693  ? 191 LEU B CD2 1 
ATOM   4132 N  N   . THR B 1 234 ? 21.58708 0.29896   -82.03454  1.000 16.70353  ? 192 THR B N   1 
ATOM   4133 C  CA  . THR B 1 234 ? 21.81637 0.45631   -80.60495  1.000 17.70420  ? 192 THR B CA  1 
ATOM   4134 C  C   . THR B 1 234 ? 23.12616 -0.22268  -80.24648  1.000 23.26162  ? 192 THR B C   1 
ATOM   4135 O  O   . THR B 1 234 ? 23.48943 -1.23898  -80.84147  1.000 18.45024  ? 192 THR B O   1 
ATOM   4136 C  CB  . THR B 1 234 ? 20.66860 -0.09149  -79.74840  1.000 18.95168  ? 192 THR B CB  1 
ATOM   4137 O  OG1 . THR B 1 234 ? 20.52230 -1.47853  -80.01014  1.000 21.03810  ? 192 THR B OG1 1 
ATOM   4138 C  CG2 . THR B 1 234 ? 19.30318 0.65711   -80.07192  1.000 17.21510  ? 192 THR B CG2 1 
ATOM   4139 N  N   . ILE B 1 235 ? 23.84028 0.37492   -79.29587  1.000 14.83107  ? 193 ILE B N   1 
ATOM   4140 C  CA  . ILE B 1 235 ? 25.10963 -0.12581  -78.80269  1.000 18.17136  ? 193 ILE B CA  1 
ATOM   4141 C  C   . ILE B 1 235 ? 24.97537 -0.24853  -77.29991  1.000 19.66880  ? 193 ILE B C   1 
ATOM   4142 O  O   . ILE B 1 235 ? 24.67529 0.74066   -76.62263  1.000 20.54666  ? 193 ILE B O   1 
ATOM   4143 C  CB  . ILE B 1 235 ? 26.25998 0.81167   -79.20002  1.000 18.97124  ? 193 ILE B CB  1 
ATOM   4144 C  CG1 . ILE B 1 235 ? 26.25301 0.86488   -80.71154  1.000 18.21183  ? 193 ILE B CG1 1 
ATOM   4145 C  CG2 . ILE B 1 235 ? 27.58433 0.30281   -78.65060  1.000 16.82548  ? 193 ILE B CG2 1 
ATOM   4146 C  CD1 . ILE B 1 235 ? 27.12046 1.84870   -81.26519  1.000 19.57591  ? 193 ILE B CD1 1 
ATOM   4147 N  N   . GLY B 1 236 ? 25.10796 -1.47017  -76.78547  1.000 16.67191  ? 194 GLY B N   1 
ATOM   4148 C  CA  . GLY B 1 236 ? 24.95389 -1.69692  -75.35489  1.000 11.89471  ? 194 GLY B CA  1 
ATOM   4149 C  C   . GLY B 1 236 ? 26.17192 -2.42701  -74.82334  1.000 19.76981  ? 194 GLY B C   1 
ATOM   4150 O  O   . GLY B 1 236 ? 26.45043 -3.52780  -75.29411  1.000 20.40472  ? 194 GLY B O   1 
ATOM   4151 N  N   . ILE B 1 237 ? 26.90461 -1.84791  -73.86544  1.000 14.67450  ? 195 ILE B N   1 
ATOM   4152 C  CA  . ILE B 1 237 ? 28.08841 -2.48516  -73.28371  1.000 18.09045  ? 195 ILE B CA  1 
ATOM   4153 C  C   . ILE B 1 237 ? 27.70431 -3.16305  -71.97828  1.000 14.75696  ? 195 ILE B C   1 
ATOM   4154 O  O   . ILE B 1 237 ? 27.07349 -2.54682  -71.10987  1.000 18.25114  ? 195 ILE B O   1 
ATOM   4155 C  CB  . ILE B 1 237 ? 29.20857 -1.46199  -73.04424  1.000 17.31158  ? 195 ILE B CB  1 
ATOM   4156 C  CG1 . ILE B 1 237 ? 29.59457 -0.75827  -74.34904  1.000 20.15943  ? 195 ILE B CG1 1 
ATOM   4157 C  CG2 . ILE B 1 237 ? 30.41170 -2.15669  -72.42324  1.000 18.40138  ? 195 ILE B CG2 1 
ATOM   4158 C  CD1 . ILE B 1 237 ? 30.45481 0.50533   -74.16576  1.000 17.85736  ? 195 ILE B CD1 1 
ATOM   4159 N  N   . SER B 1 238 ? 28.08822 -4.43290  -71.83395  1.000 14.68638  ? 196 SER B N   1 
ATOM   4160 C  CA  . SER B 1 238 ? 27.90496 -5.15445  -70.59005  1.000 15.21067  ? 196 SER B CA  1 
ATOM   4161 C  C   . SER B 1 238 ? 29.10114 -6.08141  -70.41953  1.000 21.09750  ? 196 SER B C   1 
ATOM   4162 O  O   . SER B 1 238 ? 30.02419 -6.09912  -71.24622  1.000 21.62556  ? 196 SER B O   1 
ATOM   4163 C  CB  . SER B 1 238 ? 26.54806 -5.90283  -70.58533  1.000 12.80887  ? 196 SER B CB  1 
ATOM   4164 O  OG  . SER B 1 238 ? 26.20789 -6.30614  -69.26164  1.000 18.92107  ? 196 SER B OG  1 
ATOM   4165 N  N   . GLY B 1 239 ? 29.13260 -6.80348  -69.31489  1.000 17.47744  ? 197 GLY B N   1 
ATOM   4166 C  CA  . GLY B 1 239 ? 30.28732 -7.62917  -69.04331  1.000 18.80048  ? 197 GLY B CA  1 
ATOM   4167 C  C   . GLY B 1 239 ? 31.16922 -7.04800  -67.95486  1.000 23.38778  ? 197 GLY B C   1 
ATOM   4168 O  O   . GLY B 1 239 ? 30.91576 -5.96172  -67.42244  1.000 14.37098  ? 197 GLY B O   1 
ATOM   4169 N  N   . PRO B 1 240 ? 32.24399 -7.75960  -67.62083  1.000 23.25131  ? 198 PRO B N   1 
ATOM   4170 C  CA  . PRO B 1 240 ? 33.13995 -7.30463  -66.55001  1.000 24.80703  ? 198 PRO B CA  1 
ATOM   4171 C  C   . PRO B 1 240 ? 33.94639 -6.06658  -66.93702  1.000 19.44474  ? 198 PRO B C   1 
ATOM   4172 O  O   . PRO B 1 240 ? 34.23372 -5.80038  -68.10955  1.000 18.40189  ? 198 PRO B O   1 
ATOM   4173 C  CB  . PRO B 1 240 ? 34.06618 -8.51025  -66.33603  1.000 18.81265  ? 198 PRO B CB  1 
ATOM   4174 C  CG  . PRO B 1 240 ? 34.11790 -9.15000  -67.67579  1.000 17.97080  ? 198 PRO B CG  1 
ATOM   4175 C  CD  . PRO B 1 240 ? 32.70931 -9.01073  -68.23817  1.000 20.12343  ? 198 PRO B CD  1 
ATOM   4176 N  N   . ASP B 1 241 ? 34.37857 -5.33705  -65.90430  1.000 15.53245  ? 199 ASP B N   1 
ATOM   4177 C  CA  . ASP B 1 241 ? 35.23056 -4.16856  -66.14427  1.000 22.72043  ? 199 ASP B CA  1 
ATOM   4178 C  C   . ASP B 1 241 ? 36.44963 -4.48240  -66.98680  1.000 21.87613  ? 199 ASP B C   1 
ATOM   4179 O  O   . ASP B 1 241 ? 36.85481 -3.64643  -67.80807  1.000 20.37448  ? 199 ASP B O   1 
ATOM   4180 C  CB  . ASP B 1 241 ? 35.70063 -3.56593  -64.82828  1.000 19.85048  ? 199 ASP B CB  1 
ATOM   4181 C  CG  . ASP B 1 241 ? 34.60996 -2.78477  -64.14802  1.000 21.04419  ? 199 ASP B CG  1 
ATOM   4182 O  OD1 . ASP B 1 241 ? 33.48642 -2.71079  -64.70793  1.000 25.02757  ? 199 ASP B OD1 1 
ATOM   4183 O  OD2 . ASP B 1 241 ? 34.87357 -2.25859  -63.05044  1.000 23.94941  ? 199 ASP B OD2 1 
ATOM   4184 N  N   . ASN B 1 242 ? 37.02778 -5.68595  -66.82773  1.000 20.24394  ? 200 ASN B N   1 
ATOM   4185 C  CA  . ASN B 1 242 ? 38.29154 -6.04187  -67.46236  1.000 22.15957  ? 200 ASN B CA  1 
ATOM   4186 C  C   . ASN B 1 242 ? 38.11338 -6.74473  -68.79317  1.000 24.36346  ? 200 ASN B C   1 
ATOM   4187 O  O   . ASN B 1 242 ? 39.10169 -7.23791  -69.34277  1.000 26.31929  ? 200 ASN B O   1 
ATOM   4188 C  CB  . ASN B 1 242 ? 39.14941 -6.91931  -66.53815  1.000 16.60665  ? 200 ASN B CB  1 
ATOM   4189 C  CG  . ASN B 1 242 ? 38.52824 -8.32715  -66.27604  1.000 31.79195  ? 200 ASN B CG  1 
ATOM   4190 O  OD1 . ASN B 1 242 ? 37.50984 -8.71626  -66.86101  1.000 27.28561  ? 200 ASN B OD1 1 
ATOM   4191 N  ND2 . ASN B 1 242 ? 39.16073 -9.08372  -65.38144  1.000 25.41443  ? 200 ASN B ND2 1 
ATOM   4192 N  N   . GLY B 1 243 ? 36.89063 -6.81913  -69.31302  1.000 24.84299  ? 201 GLY B N   1 
ATOM   4193 C  CA  . GLY B 1 243 ? 36.63788 -7.44956  -70.59812  1.000 19.94198  ? 201 GLY B CA  1 
ATOM   4194 C  C   . GLY B 1 243 ? 35.25172 -7.17048  -71.14371  1.000 24.94934  ? 201 GLY B C   1 
ATOM   4195 O  O   . GLY B 1 243 ? 34.63150 -8.03874  -71.76515  1.000 25.93436  ? 201 GLY B O   1 
ATOM   4196 N  N   . ALA B 1 244 ? 34.75716 -5.95184  -70.92318  1.000 22.17051  ? 202 ALA B N   1 
ATOM   4197 C  CA  . ALA B 1 244 ? 33.42865 -5.57581  -71.37488  1.000 18.48767  ? 202 ALA B CA  1 
ATOM   4198 C  C   . ALA B 1 244 ? 33.27972 -5.73839  -72.88471  1.000 18.68484  ? 202 ALA B C   1 
ATOM   4199 O  O   . ALA B 1 244 ? 34.24613 -5.60179  -73.64466  1.000 16.34429  ? 202 ALA B O   1 
ATOM   4200 C  CB  . ALA B 1 244 ? 33.13446 -4.11499  -70.97525  1.000 23.74424  ? 202 ALA B CB  1 
ATOM   4201 N  N   . VAL B 1 245 ? 32.03441 -5.98964  -73.33023  1.000 22.91494  ? 203 VAL B N   1 
ATOM   4202 C  CA  . VAL B 1 245 ? 31.73320 -6.18654  -74.75308  1.000 15.34343  ? 203 VAL B CA  1 
ATOM   4203 C  C   . VAL B 1 245 ? 30.53986 -5.31359  -75.14595  1.000 21.09778  ? 203 VAL B C   1 
ATOM   4204 O  O   . VAL B 1 245 ? 29.45906 -5.40589  -74.54102  1.000 21.18494  ? 203 VAL B O   1 
ATOM   4205 C  CB  . VAL B 1 245 ? 31.45748 -7.66994  -75.09076  1.000 18.53632  ? 203 VAL B CB  1 
ATOM   4206 C  CG1 . VAL B 1 245 ? 30.94322 -7.79676  -76.50638  1.000 18.35376  ? 203 VAL B CG1 1 
ATOM   4207 C  CG2 . VAL B 1 245 ? 32.72723 -8.49491  -74.93986  1.000 22.79301  ? 203 VAL B CG2 1 
ATOM   4208 N  N   . ALA B 1 246 ? 30.72994 -4.47577  -76.16193  1.000 23.64186  ? 204 ALA B N   1 
ATOM   4209 C  CA  . ALA B 1 246 ? 29.62639 -3.74774  -76.76396  1.000 17.42155  ? 204 ALA B CA  1 
ATOM   4210 C  C   . ALA B 1 246 ? 28.89771 -4.65062  -77.75417  1.000 22.74194  ? 204 ALA B C   1 
ATOM   4211 O  O   . ALA B 1 246 ? 29.50287 -5.18922  -78.69277  1.000 18.00809  ? 204 ALA B O   1 
ATOM   4212 C  CB  . ALA B 1 246 ? 30.12603 -2.47331  -77.44855  1.000 20.93418  ? 204 ALA B CB  1 
ATOM   4213 N  N   . VAL B 1 247 ? 27.59693 -4.82840  -77.52840  1.000 19.99529  ? 205 VAL B N   1 
ATOM   4214 C  CA  . VAL B 1 247 ? 26.71944 -5.56781  -78.43032  1.000 22.28290  ? 205 VAL B CA  1 
ATOM   4215 C  C   . VAL B 1 247 ? 26.00701 -4.55998  -79.31854  1.000 17.62648  ? 205 VAL B C   1 
ATOM   4216 O  O   . VAL B 1 247 ? 25.38198 -3.62788  -78.81864  1.000 13.38658  ? 205 VAL B O   1 
ATOM   4217 C  CB  . VAL B 1 247 ? 25.73014 -6.42918  -77.64119  1.000 22.06290  ? 205 VAL B CB  1 
ATOM   4218 C  CG1 . VAL B 1 247 ? 24.71227 -7.05178  -78.56978  1.000 17.36402  ? 205 VAL B CG1 1 
ATOM   4219 C  CG2 . VAL B 1 247 ? 26.52620 -7.50118  -76.91019  1.000 14.04126  ? 205 VAL B CG2 1 
ATOM   4220 N  N   . VAL B 1 248 ? 26.15175 -4.71226  -80.62885  1.000 17.23174  ? 206 VAL B N   1 
ATOM   4221 C  CA  . VAL B 1 248 ? 25.64260 -3.77299  -81.62015  1.000 19.56492  ? 206 VAL B CA  1 
ATOM   4222 C  C   . VAL B 1 248 ? 24.42556 -4.41340  -82.27074  1.000 17.94558  ? 206 VAL B C   1 
ATOM   4223 O  O   . VAL B 1 248 ? 24.49494 -5.55909  -82.73669  1.000 20.10521  ? 206 VAL B O   1 
ATOM   4224 C  CB  . VAL B 1 248 ? 26.71668 -3.43808  -82.67668  1.000 16.92539  ? 206 VAL B CB  1 
ATOM   4225 C  CG1 . VAL B 1 248 ? 26.21646 -2.39983  -83.63935  1.000 18.99052  ? 206 VAL B CG1 1 
ATOM   4226 C  CG2 . VAL B 1 248 ? 27.99675 -2.93736  -82.00398  1.000 17.35673  ? 206 VAL B CG2 1 
ATOM   4227 N  N   . LYS B 1 249 ? 23.31271 -3.68943  -82.28844  1.000 21.19848  ? 207 LYS B N   1 
ATOM   4228 C  CA  . LYS B 1 249 ? 22.07388 -4.17016  -82.88140  1.000 19.49970  ? 207 LYS B CA  1 
ATOM   4229 C  C   . LYS B 1 249 ? 21.59565 -3.17885  -83.91939  1.000 21.18967  ? 207 LYS B C   1 
ATOM   4230 O  O   . LYS B 1 249 ? 21.69795 -1.95337  -83.73004  1.000 23.36371  ? 207 LYS B O   1 
ATOM   4231 C  CB  . LYS B 1 249 ? 20.96531 -4.37271  -81.83152  1.000 22.60429  ? 207 LYS B CB  1 
ATOM   4232 C  CG  . LYS B 1 249 ? 21.17883 -5.58497  -80.92715  1.000 16.85934  ? 207 LYS B CG  1 
ATOM   4233 C  CD  . LYS B 1 249 ? 20.28750 -5.49242  -79.72581  1.000 23.27357  ? 207 LYS B CD  1 
ATOM   4234 C  CE  . LYS B 1 249 ? 20.40695 -6.73033  -78.84628  1.000 23.83471  ? 207 LYS B CE  1 
ATOM   4235 N  NZ  . LYS B 1 249 ? 19.31878 -6.78128  -77.85305  1.000 18.38247  ? 207 LYS B NZ  1 
ATOM   4236 N  N   . TYR B 1 250 ? 21.09843 -3.72087  -85.01947  1.000 19.12493  ? 208 TYR B N   1 
ATOM   4237 C  CA  . TYR B 1 250 ? 20.45098 -2.94780  -86.06747  1.000 22.53038  ? 208 TYR B CA  1 
ATOM   4238 C  C   . TYR B 1 250 ? 19.06809 -3.54757  -86.26061  1.000 21.54730  ? 208 TYR B C   1 
ATOM   4239 O  O   . TYR B 1 250 ? 18.94118 -4.76088  -86.48759  1.000 22.65138  ? 208 TYR B O   1 
ATOM   4240 C  CB  . TYR B 1 250 ? 21.25470 -2.99872  -87.35542  1.000 16.16624  ? 208 TYR B CB  1 
ATOM   4241 C  CG  . TYR B 1 250 ? 20.81182 -2.06075  -88.45587  1.000 25.79524  ? 208 TYR B CG  1 
ATOM   4242 C  CD1 . TYR B 1 250 ? 21.02707 -0.68322  -88.36665  1.000 21.24641  ? 208 TYR B CD1 1 
ATOM   4243 C  CD2 . TYR B 1 250 ? 20.22482 -2.55482  -89.61767  1.000 25.22718  ? 208 TYR B CD2 1 
ATOM   4244 C  CE1 . TYR B 1 250 ? 20.65350 0.17743   -89.40372  1.000 17.07570  ? 208 TYR B CE1 1 
ATOM   4245 C  CE2 . TYR B 1 250 ? 19.84063 -1.69851  -90.65031  1.000 26.22346  ? 208 TYR B CE2 1 
ATOM   4246 C  CZ  . TYR B 1 250 ? 20.07742 -0.35217  -90.54471  1.000 19.49282  ? 208 TYR B CZ  1 
ATOM   4247 O  OH  . TYR B 1 250 ? 19.71736 0.46364   -91.58558  1.000 24.02307  ? 208 TYR B OH  1 
ATOM   4248 N  N   . ASN B 1 251 ? 18.04682 -2.71695  -86.13217  1.000 19.27908  ? 209 ASN B N   1 
ATOM   4249 C  CA  . ASN B 1 251 ? 16.65966 -3.17092  -86.18307  1.000 15.88759  ? 209 ASN B CA  1 
ATOM   4250 C  C   . ASN B 1 251 ? 16.41911 -4.28479  -85.15859  1.000 22.35015  ? 209 ASN B C   1 
ATOM   4251 O  O   . ASN B 1 251 ? 15.69545 -5.25084  -85.40948  1.000 22.00562  ? 209 ASN B O   1 
ATOM   4252 C  CB  . ASN B 1 251 ? 16.27205 -3.62415  -87.59553  1.000 26.05606  ? 209 ASN B CB  1 
ATOM   4253 C  CG  . ASN B 1 251 ? 14.73958 -3.70992  -87.77799  1.000 34.06794  ? 209 ASN B CG  1 
ATOM   4254 O  OD1 . ASN B 1 251 ? 13.99708 -3.07101  -87.05358  1.000 28.94272  ? 209 ASN B OD1 1 
ATOM   4255 N  ND2 . ASN B 1 251 ? 14.29071 -4.50016  -88.72365  1.000 33.21211  ? 209 ASN B ND2 1 
ATOM   4256 N  N   . GLY B 1 252 ? 17.03490 -4.14270  -83.98842  1.000 19.00047  ? 210 GLY B N   1 
ATOM   4257 C  CA  . GLY B 1 252 ? 16.82775 -5.04237  -82.88452  1.000 17.54567  ? 210 GLY B CA  1 
ATOM   4258 C  C   . GLY B 1 252 ? 17.55543 -6.37811  -82.97824  1.000 24.17757  ? 210 GLY B C   1 
ATOM   4259 O  O   . GLY B 1 252 ? 17.43327 -7.19074  -82.05141  1.000 24.83391  ? 210 GLY B O   1 
ATOM   4260 N  N   . ILE B 1 253 ? 18.30484 -6.63532  -84.05374  1.000 22.40330  ? 211 ILE B N   1 
ATOM   4261 C  CA  . ILE B 1 253 ? 19.01390 -7.89770  -84.25541  1.000 17.37881  ? 211 ILE B CA  1 
ATOM   4262 C  C   . ILE B 1 253 ? 20.51090 -7.66332  -84.05563  1.000 21.83885  ? 211 ILE B C   1 
ATOM   4263 O  O   . ILE B 1 253 ? 21.07455 -6.72857  -84.63079  1.000 20.78675  ? 211 ILE B O   1 
ATOM   4264 C  CB  . ILE B 1 253 ? 18.73239 -8.46566  -85.65832  1.000 24.95153  ? 211 ILE B CB  1 
ATOM   4265 C  CG1 . ILE B 1 253 ? 17.24394 -8.85381  -85.79097  1.000 35.37694  ? 211 ILE B CG1 1 
ATOM   4266 C  CG2 . ILE B 1 253 ? 19.66903 -9.64765  -85.97487  1.000 19.71136  ? 211 ILE B CG2 1 
ATOM   4267 C  CD1 . ILE B 1 253 ? 16.68679 -8.66258  -87.17459  1.000 29.47866  ? 211 ILE B CD1 1 
ATOM   4268 N  N   . ILE B 1 254 ? 21.16724 -8.55340  -83.29846  1.000 22.71988  ? 212 ILE B N   1 
ATOM   4269 C  CA  . ILE B 1 254 ? 22.60218 -8.41404  -83.07928  1.000 20.22415  ? 212 ILE B CA  1 
ATOM   4270 C  C   . ILE B 1 254 ? 23.33284 -8.51757  -84.40350  1.000 21.75957  ? 212 ILE B C   1 
ATOM   4271 O  O   . ILE B 1 254 ? 23.15512 -9.47130  -85.16850  1.000 21.34578  ? 212 ILE B O   1 
ATOM   4272 C  CB  . ILE B 1 254 ? 23.11722 -9.45978  -82.08970  1.000 19.56921  ? 212 ILE B CB  1 
ATOM   4273 C  CG1 . ILE B 1 254 ? 22.57551 -9.17276  -80.70148  1.000 19.84490  ? 212 ILE B CG1 1 
ATOM   4274 C  CG2 . ILE B 1 254 ? 24.68937 -9.45111  -82.05282  1.000 19.04435  ? 212 ILE B CG2 1 
ATOM   4275 C  CD1 . ILE B 1 254 ? 23.00958 -10.23509 -79.65731  1.000 14.37683  ? 212 ILE B CD1 1 
ATOM   4276 N  N   . THR B 1 255 ? 24.14377 -7.51017  -84.69405  1.000 20.59220  ? 213 THR B N   1 
ATOM   4277 C  CA  . THR B 1 255 ? 24.88169 -7.45454  -85.93684  1.000 12.69274  ? 213 THR B CA  1 
ATOM   4278 C  C   . THR B 1 255 ? 26.38165 -7.40056  -85.72639  1.000 18.88186  ? 213 THR B C   1 
ATOM   4279 O  O   . THR B 1 255 ? 27.10670 -7.63631  -86.67949  1.000 22.36070  ? 213 THR B O   1 
ATOM   4280 C  CB  . THR B 1 255 ? 24.45851 -6.23214  -86.77518  1.000 21.54969  ? 213 THR B CB  1 
ATOM   4281 O  OG1 . THR B 1 255 ? 24.47061 -5.08070  -85.93358  1.000 23.97802  ? 213 THR B OG1 1 
ATOM   4282 C  CG2 . THR B 1 255 ? 23.05629 -6.40408  -87.34168  1.000 27.24103  ? 213 THR B CG2 1 
ATOM   4283 N  N   . ASP B 1 256 ? 26.86662 -7.04177  -84.53858  1.000 19.57312  ? 214 ASP B N   1 
ATOM   4284 C  CA  . ASP B 1 256 ? 28.30189 -6.95725  -84.31058  1.000 17.16879  ? 214 ASP B CA  1 
ATOM   4285 C  C   . ASP B 1 256 ? 28.57858 -6.91015  -82.81962  1.000 18.44783  ? 214 ASP B C   1 
ATOM   4286 O  O   . ASP B 1 256 ? 27.67228 -6.70744  -82.00798  1.000 20.49353  ? 214 ASP B O   1 
ATOM   4287 C  CB  . ASP B 1 256 ? 28.93208 -5.74539  -85.00770  1.000 22.78920  ? 214 ASP B CB  1 
ATOM   4288 C  CG  . ASP B 1 256 ? 30.28901 -6.07790  -85.59242  1.000 26.50900  ? 214 ASP B CG  1 
ATOM   4289 O  OD1 . ASP B 1 256 ? 30.85065 -7.11340  -85.16258  1.000 28.48182  ? 214 ASP B OD1 1 
ATOM   4290 O  OD2 . ASP B 1 256 ? 30.78639 -5.33358  -86.46649  1.000 26.57750  ? 214 ASP B OD2 1 
ATOM   4291 N  N   . THR B 1 257 ? 29.84966 -7.14070  -82.46262  1.000 20.15219  ? 215 THR B N   1 
ATOM   4292 C  CA  . THR B 1 257 ? 30.33983 -6.92271  -81.10749  1.000 17.25799  ? 215 THR B CA  1 
ATOM   4293 C  C   . THR B 1 257 ? 31.67643 -6.19775  -81.18178  1.000 23.82148  ? 215 THR B C   1 
ATOM   4294 O  O   . THR B 1 257 ? 32.36779 -6.24236  -82.20169  1.000 22.51097  ? 215 THR B O   1 
ATOM   4295 C  CB  . THR B 1 257 ? 30.51407 -8.21697  -80.31956  1.000 26.19349  ? 215 THR B CB  1 
ATOM   4296 O  OG1 . THR B 1 257 ? 31.49536 -9.03152  -80.96906  1.000 23.55406  ? 215 THR B OG1 1 
ATOM   4297 C  CG2 . THR B 1 257 ? 29.15677 -8.97825  -80.19274  1.000 18.27551  ? 215 THR B CG2 1 
ATOM   4298 N  N   . ILE B 1 258 ? 32.00510 -5.47277  -80.11503  1.000 20.34132  ? 216 ILE B N   1 
ATOM   4299 C  CA  . ILE B 1 258 ? 33.27882 -4.76967  -79.98781  1.000 21.54676  ? 216 ILE B CA  1 
ATOM   4300 C  C   . ILE B 1 258 ? 33.78057 -5.05634  -78.59148  1.000 22.81074  ? 216 ILE B C   1 
ATOM   4301 O  O   . ILE B 1 258 ? 33.11796 -4.69024  -77.61205  1.000 20.28600  ? 216 ILE B O   1 
ATOM   4302 C  CB  . ILE B 1 258 ? 33.13632 -3.25637  -80.18463  1.000 19.05183  ? 216 ILE B CB  1 
ATOM   4303 C  CG1 . ILE B 1 258 ? 32.56069 -2.93951  -81.56786  1.000 20.51972  ? 216 ILE B CG1 1 
ATOM   4304 C  CG2 . ILE B 1 258 ? 34.49511 -2.52116  -79.84919  1.000 19.04022  ? 216 ILE B CG2 1 
ATOM   4305 C  CD1 . ILE B 1 258 ? 31.91514 -1.55585  -81.65984  1.000 18.47594  ? 216 ILE B CD1 1 
ATOM   4306 N  N   . LYS B 1 259 ? 34.94151 -5.68995  -78.48201  1.000 16.48002  ? 217 LYS B N   1 
ATOM   4307 C  CA  . LYS B 1 259 ? 35.42136 -6.00951  -77.15244  1.000 15.45117  ? 217 LYS B CA  1 
ATOM   4308 C  C   . LYS B 1 259 ? 36.42520 -4.98023  -76.65042  1.000 14.37870  ? 217 LYS B C   1 
ATOM   4309 O  O   . LYS B 1 259 ? 37.12082 -4.31416  -77.41682  1.000 18.11703  ? 217 LYS B O   1 
ATOM   4310 C  CB  . LYS B 1 259 ? 36.04373 -7.41000  -77.10525  1.000 20.44960  ? 217 LYS B CB  1 
ATOM   4311 C  CG  . LYS B 1 259 ? 36.22789 -7.90942  -75.66108  1.000 26.98374  ? 217 LYS B CG  1 
ATOM   4312 C  CD  . LYS B 1 259 ? 36.36465 -9.47492  -75.52231  1.000 20.76274  ? 217 LYS B CD  1 
ATOM   4313 C  CE  . LYS B 1 259 ? 36.41466 -9.85023  -74.03779  1.000 19.80671  ? 217 LYS B CE  1 
ATOM   4314 N  NZ  . LYS B 1 259 ? 36.53482 -11.37765 -73.87268  1.000 20.94137  ? 217 LYS B NZ  1 
ATOM   4315 N  N   . SER B 1 260 ? 36.42988 -4.82381  -75.33540  1.000 19.03734  ? 218 SER B N   1 
ATOM   4316 C  CA  . SER B 1 260 ? 37.36941 -3.97619  -74.64638  1.000 18.60506  ? 218 SER B CA  1 
ATOM   4317 C  C   . SER B 1 260 ? 38.76049 -4.29916  -75.14931  1.000 22.90650  ? 218 SER B C   1 
ATOM   4318 O  O   . SER B 1 260 ? 39.15108 -5.46480  -75.17688  1.000 20.44275  ? 218 SER B O   1 
ATOM   4319 C  CB  . SER B 1 260 ? 37.23762 -4.25901  -73.15858  1.000 17.85440  ? 218 SER B CB  1 
ATOM   4320 O  OG  . SER B 1 260 ? 38.18097 -3.56988  -72.38653  1.000 22.31867  ? 218 SER B OG  1 
ATOM   4321 N  N   . TRP B 1 261 ? 39.48362 -3.28898  -75.62147  1.000 20.12035  ? 219 TRP B N   1 
ATOM   4322 C  CA  . TRP B 1 261 ? 40.82234 -3.51225  -76.14969  1.000 17.13964  ? 219 TRP B CA  1 
ATOM   4323 C  C   . TRP B 1 261 ? 41.91902 -3.10358  -75.17491  1.000 26.82045  ? 219 TRP B C   1 
ATOM   4324 O  O   . TRP B 1 261 ? 43.09106 -3.28136  -75.48373  1.000 27.33077  ? 219 TRP B O   1 
ATOM   4325 C  CB  . TRP B 1 261 ? 41.01326 -2.78277  -77.48955  1.000 24.58962  ? 219 TRP B CB  1 
ATOM   4326 C  CG  . TRP B 1 261 ? 40.99385 -1.27110  -77.34271  1.000 20.55795  ? 219 TRP B CG  1 
ATOM   4327 C  CD1 . TRP B 1 261 ? 42.06555 -0.45814  -77.08996  1.000 19.72880  ? 219 TRP B CD1 1 
ATOM   4328 C  CD2 . TRP B 1 261 ? 39.85011 -0.40453  -77.45733  1.000 23.92504  ? 219 TRP B CD2 1 
ATOM   4329 N  NE1 . TRP B 1 261 ? 41.65540 0.86367   -77.03152  1.000 23.70934  ? 219 TRP B NE1 1 
ATOM   4330 C  CE2 . TRP B 1 261 ? 40.30187 0.92194   -77.24108  1.000 24.26646  ? 219 TRP B CE2 1 
ATOM   4331 C  CE3 . TRP B 1 261 ? 38.49269 -0.62061  -77.70417  1.000 27.14691  ? 219 TRP B CE3 1 
ATOM   4332 C  CZ2 . TRP B 1 261 ? 39.43597 2.02635   -77.27033  1.000 27.40551  ? 219 TRP B CZ2 1 
ATOM   4333 C  CZ3 . TRP B 1 261 ? 37.63965 0.47673   -77.75237  1.000 19.97181  ? 219 TRP B CZ3 1 
ATOM   4334 C  CH2 . TRP B 1 261 ? 38.11184 1.78378   -77.52758  1.000 25.36155  ? 219 TRP B CH2 1 
ATOM   4335 N  N   . ARG B 1 262 ? 41.57348 -2.55129  -74.01670  1.000 22.52579  ? 220 ARG B N   1 
ATOM   4336 C  CA  . ARG B 1 262 ? 42.52935 -2.19350  -72.97742  1.000 22.77944  ? 220 ARG B CA  1 
ATOM   4337 C  C   . ARG B 1 262 ? 42.16850 -2.84290  -71.66497  1.000 20.65509  ? 220 ARG B C   1 
ATOM   4338 O  O   . ARG B 1 262 ? 42.84979 -2.59440  -70.67074  1.000 17.13785  ? 220 ARG B O   1 
ATOM   4339 C  CB  . ARG B 1 262 ? 42.55421 -0.66258  -72.72497  1.000 26.10317  ? 220 ARG B CB  1 
ATOM   4340 C  CG  . ARG B 1 262 ? 42.97452 0.27325   -73.84186  1.000 29.34888  ? 220 ARG B CG  1 
ATOM   4341 C  CD  . ARG B 1 262 ? 44.45703 0.44917   -73.75850  1.000 33.12205  ? 220 ARG B CD  1 
ATOM   4342 N  NE  . ARG B 1 262 ? 44.78322 1.01217   -72.45107  1.000 39.39835  ? 220 ARG B NE  1 
ATOM   4343 C  CZ  . ARG B 1 262 ? 45.29052 2.21550   -72.18838  1.000 38.33687  ? 220 ARG B CZ  1 
ATOM   4344 N  NH1 . ARG B 1 262 ? 45.71278 3.03656   -73.15082  1.000 30.05336  ? 220 ARG B NH1 1 
ATOM   4345 N  NH2 . ARG B 1 262 ? 45.42095 2.58793   -70.91760  1.000 32.84785  ? 220 ARG B NH2 1 
ATOM   4346 N  N   . ASN B 1 263 ? 41.02706 -3.53636  -71.59796  1.000 19.31963  ? 221 ASN B N   1 
ATOM   4347 C  CA  . ASN B 1 263 ? 40.61973 -4.25138  -70.39993  1.000 15.91031  ? 221 ASN B CA  1 
ATOM   4348 C  C   . ASN B 1 263 ? 40.45013 -3.31810  -69.20811  1.000 17.18175  ? 221 ASN B C   1 
ATOM   4349 O  O   . ASN B 1 263 ? 40.72680 -3.68313  -68.06688  1.000 18.11968  ? 221 ASN B O   1 
ATOM   4350 C  CB  . ASN B 1 263 ? 41.62622 -5.36012  -70.10982  1.000 21.85513  ? 221 ASN B CB  1 
ATOM   4351 C  CG  . ASN B 1 263 ? 41.89721 -6.17673  -71.34289  1.000 21.81960  ? 221 ASN B CG  1 
ATOM   4352 O  OD1 . ASN B 1 263 ? 42.91566 -5.97656  -72.01396  1.000 29.81249  ? 221 ASN B OD1 1 
ATOM   4353 N  ND2 . ASN B 1 263 ? 40.94308 -7.00408  -71.72656  1.000 22.56304  ? 221 ASN B ND2 1 
ATOM   4354 N  N   . ASN B 1 264 ? 39.94984 -2.08368  -69.45213  1.000 21.00903  ? 222 ASN B N   1 
ATOM   4355 C  CA  . ASN B 1 264 ? 39.72135 -1.15089  -68.35455  1.000 19.17680  ? 222 ASN B CA  1 
ATOM   4356 C  C   . ASN B 1 264 ? 38.46423 -0.31142  -68.63887  1.000 22.83888  ? 222 ASN B C   1 
ATOM   4357 O  O   . ASN B 1 264 ? 38.53631 0.89787   -68.92010  1.000 23.75895  ? 222 ASN B O   1 
ATOM   4358 C  CB  . ASN B 1 264 ? 40.95827 -0.27735  -68.10309  1.000 20.28076  ? 222 ASN B CB  1 
ATOM   4359 C  CG  . ASN B 1 264 ? 40.85676 0.51831   -66.80371  1.000 27.23670  ? 222 ASN B CG  1 
ATOM   4360 O  OD1 . ASN B 1 264 ? 39.86435 0.40344   -66.06008  1.000 33.23903  ? 222 ASN B OD1 1 
ATOM   4361 N  ND2 . ASN B 1 264 ? 41.88689 1.29739   -66.50499  1.000 22.54969  ? 222 ASN B ND2 1 
ATOM   4362 N  N   . ILE B 1 265 ? 37.30471 -0.97970  -68.54647  1.000 22.17026  ? 223 ILE B N   1 
ATOM   4363 C  CA  . ILE B 1 265 ? 35.96338 -0.38998  -68.60339  1.000 18.13407  ? 223 ILE B CA  1 
ATOM   4364 C  C   . ILE B 1 265 ? 35.71933 0.29766   -69.93470  1.000 15.61902  ? 223 ILE B C   1 
ATOM   4365 O  O   . ILE B 1 265 ? 35.62483 1.52340   -69.98664  1.000 15.53713  ? 223 ILE B O   1 
ATOM   4366 C  CB  . ILE B 1 265 ? 35.72713 0.62677   -67.46823  1.000 16.93020  ? 223 ILE B CB  1 
ATOM   4367 C  CG1 . ILE B 1 265 ? 36.14809 0.07979   -66.11806  1.000 18.98965  ? 223 ILE B CG1 1 
ATOM   4368 C  CG2 . ILE B 1 265 ? 34.22101 1.05584   -67.39192  1.000 20.91649  ? 223 ILE B CG2 1 
ATOM   4369 C  CD1 . ILE B 1 265 ? 36.02018 1.12809   -64.99956  1.000 20.89719  ? 223 ILE B CD1 1 
ATOM   4370 N  N   . LEU B 1 266 ? 35.63602 -0.47257  -71.01654  1.000 17.98723  ? 224 LEU B N   1 
ATOM   4371 C  CA  . LEU B 1 266 ? 35.13096 0.05639   -72.27729  1.000 20.18506  ? 224 LEU B CA  1 
ATOM   4372 C  C   . LEU B 1 266 ? 33.81054 0.80590   -72.03087  1.000 22.79136  ? 224 LEU B C   1 
ATOM   4373 O  O   . LEU B 1 266 ? 32.94450 0.32838   -71.29185  1.000 21.29379  ? 224 LEU B O   1 
ATOM   4374 C  CB  . LEU B 1 266 ? 34.91088 -1.11436  -73.25311  1.000 20.31807  ? 224 LEU B CB  1 
ATOM   4375 C  CG  . LEU B 1 266 ? 34.33619 -0.85497  -74.65461  1.000 23.62761  ? 224 LEU B CG  1 
ATOM   4376 C  CD1 . LEU B 1 266 ? 35.32377 -0.13459  -75.48608  1.000 18.95464  ? 224 LEU B CD1 1 
ATOM   4377 C  CD2 . LEU B 1 266 ? 33.88789 -2.10557  -75.35313  1.000 20.81506  ? 224 LEU B CD2 1 
ATOM   4378 N  N   . ARG B 1 267 ? 33.66003 1.98939   -72.62835  1.000 19.43230  ? 225 ARG B N   1 
ATOM   4379 C  CA  . ARG B 1 267 ? 32.50209 2.84197   -72.32470  1.000 17.42775  ? 225 ARG B CA  1 
ATOM   4380 C  C   . ARG B 1 267 ? 32.26979 3.81301   -73.47452  1.000 16.32777  ? 225 ARG B C   1 
ATOM   4381 O  O   . ARG B 1 267 ? 33.19779 4.13338   -74.22010  1.000 28.40978  ? 225 ARG B O   1 
ATOM   4382 C  CB  . ARG B 1 267 ? 32.70443 3.58685   -71.00262  1.000 17.84930  ? 225 ARG B CB  1 
ATOM   4383 C  CG  . ARG B 1 267 ? 34.01049 4.43181   -70.93227  1.000 18.92795  ? 225 ARG B CG  1 
ATOM   4384 C  CD  . ARG B 1 267 ? 34.35857 4.72673   -69.48293  1.000 16.17089  ? 225 ARG B CD  1 
ATOM   4385 N  NE  . ARG B 1 267 ? 35.53742 5.59095   -69.32454  1.000 19.47436  ? 225 ARG B NE  1 
ATOM   4386 C  CZ  . ARG B 1 267 ? 36.78592 5.14140   -69.21334  1.000 21.80775  ? 225 ARG B CZ  1 
ATOM   4387 N  NH1 . ARG B 1 267 ? 37.07529 3.83595   -69.32207  1.000 13.26507  ? 225 ARG B NH1 1 
ATOM   4388 N  NH2 . ARG B 1 267 ? 37.76772 6.01215   -68.97646  1.000 14.13335  ? 225 ARG B NH2 1 
ATOM   4389 N  N   . THR B 1 268 ? 31.01897 4.26025   -73.64152  1.000 17.57258  ? 226 THR B N   1 
ATOM   4390 C  CA  . THR B 1 268 ? 30.72561 5.07346   -74.81413  1.000 16.38693  ? 226 THR B CA  1 
ATOM   4391 C  C   . THR B 1 268 ? 29.88464 6.31992   -74.45473  1.000 20.05948  ? 226 THR B C   1 
ATOM   4392 O  O   . THR B 1 268 ? 29.97373 6.83222   -73.32546  1.000 17.71915  ? 226 THR B O   1 
ATOM   4393 C  CB  . THR B 1 268 ? 30.11013 4.17373   -75.90330  1.000 10.38135  ? 226 THR B CB  1 
ATOM   4394 O  OG1 . THR B 1 268 ? 29.92025 4.90655   -77.12203  1.000 18.85449  ? 226 THR B OG1 1 
ATOM   4395 C  CG2 . THR B 1 268 ? 28.79454 3.47450   -75.45027  1.000 12.37024  ? 226 THR B CG2 1 
ATOM   4396 N  N   . GLN B 1 269 ? 29.08322 6.82709   -75.39966  1.000 19.73717  ? 227 GLN B N   1 
ATOM   4397 C  CA  . GLN B 1 269 ? 28.63127 8.23197   -75.36260  1.000 15.35257  ? 227 GLN B CA  1 
ATOM   4398 C  C   . GLN B 1 269 ? 27.67184 8.55431   -74.21962  1.000 15.16959  ? 227 GLN B C   1 
ATOM   4399 O  O   . GLN B 1 269 ? 27.72446 9.66102   -73.65535  1.000 18.18989  ? 227 GLN B O   1 
ATOM   4400 C  CB  . GLN B 1 269 ? 27.96418 8.58224   -76.67832  1.000 18.42190  ? 227 GLN B CB  1 
ATOM   4401 C  CG  . GLN B 1 269 ? 28.92818 8.66053   -77.84473  1.000 17.08761  ? 227 GLN B CG  1 
ATOM   4402 C  CD  . GLN B 1 269 ? 28.17985 8.94537   -79.10179  1.000 23.08860  ? 227 GLN B CD  1 
ATOM   4403 O  OE1 . GLN B 1 269 ? 28.07594 8.08368   -79.97895  1.000 23.96601  ? 227 GLN B OE1 1 
ATOM   4404 N  NE2 . GLN B 1 269 ? 27.62728 10.16623  -79.20454  1.000 20.79793  ? 227 GLN B NE2 1 
ATOM   4405 N  N   . GLU B 1 270 ? 26.73126 7.64696   -73.92348  1.000 22.17001  ? 228 GLU B N   1 
ATOM   4406 C  CA  . GLU B 1 270 ? 25.52126 7.92521   -73.12473  1.000 11.67835  ? 228 GLU B CA  1 
ATOM   4407 C  C   . GLU B 1 270 ? 24.66718 9.02303   -73.75438  1.000 19.64658  ? 228 GLU B C   1 
ATOM   4408 O  O   . GLU B 1 270 ? 23.98958 9.77316   -73.05037  1.000 19.90764  ? 228 GLU B O   1 
ATOM   4409 C  CB  . GLU B 1 270 ? 25.82062 8.25145   -71.66136  1.000 16.60708  ? 228 GLU B CB  1 
ATOM   4410 C  CG  . GLU B 1 270 ? 27.09074 7.62094   -71.07615  1.000 19.82358  ? 228 GLU B CG  1 
ATOM   4411 C  CD  . GLU B 1 270 ? 27.10371 6.09964   -71.01172  1.000 28.27700  ? 228 GLU B CD  1 
ATOM   4412 O  OE1 . GLU B 1 270 ? 26.18344 5.41103   -71.53661  1.000 20.06141  ? 228 GLU B OE1 1 
ATOM   4413 O  OE2 . GLU B 1 270 ? 28.09836 5.57879   -70.44965  1.000 29.06953  ? 228 GLU B OE2 1 
ATOM   4414 N  N   . SER B 1 271 ? 24.71450 9.12783   -75.08034  1.000 15.61044  ? 229 SER B N   1 
ATOM   4415 C  CA  . SER B 1 271 ? 23.81202 9.95355   -75.86951  1.000 16.46464  ? 229 SER B CA  1 
ATOM   4416 C  C   . SER B 1 271 ? 23.86857 9.42913   -77.29377  1.000 19.14449  ? 229 SER B C   1 
ATOM   4417 O  O   . SER B 1 271 ? 24.62242 8.50026   -77.59420  1.000 14.88361  ? 229 SER B O   1 
ATOM   4418 C  CB  . SER B 1 271 ? 24.16235 11.44799  -75.79840  1.000 23.61134  ? 229 SER B CB  1 
ATOM   4419 O  OG  . SER B 1 271 ? 25.42412 11.76743  -76.36751  1.000 19.85585  ? 229 SER B OG  1 
ATOM   4420 N  N   . GLU B 1 272 ? 23.09927 10.05138  -78.18832  1.000 17.61077  ? 230 GLU B N   1 
ATOM   4421 C  CA  . GLU B 1 272 ? 22.91080 9.44868   -79.50253  1.000 18.80349  ? 230 GLU B CA  1 
ATOM   4422 C  C   . GLU B 1 272 ? 24.19808 9.48651   -80.32143  1.000 27.03670  ? 230 GLU B C   1 
ATOM   4423 O  O   . GLU B 1 272 ? 24.97123 10.45411  -80.23594  1.000 21.05783  ? 230 GLU B O   1 
ATOM   4424 C  CB  . GLU B 1 272 ? 21.80484 10.15862  -80.27989  1.000 18.50852  ? 230 GLU B CB  1 
ATOM   4425 C  CG  . GLU B 1 272 ? 22.16671 11.57361  -80.74926  1.000 20.39052  ? 230 GLU B CG  1 
ATOM   4426 C  CD  . GLU B 1 272 ? 21.17386 12.08746  -81.78677  1.000 31.34823  ? 230 GLU B CD  1 
ATOM   4427 O  OE1 . GLU B 1 272 ? 20.10648 11.43096  -81.99779  1.000 24.56189  ? 230 GLU B OE1 1 
ATOM   4428 O  OE2 . GLU B 1 272 ? 21.46140 13.14555  -82.39490  1.000 28.24636  ? 230 GLU B OE2 1 
ATOM   4429 N  N   . CYS B 1 273 ? 24.41787 8.42488   -81.12402  1.000 17.58386  ? 231 CYS B N   1 
ATOM   4430 C  CA  . CYS B 1 273 ? 25.43428 8.44096   -82.17521  1.000 20.13288  ? 231 CYS B CA  1 
ATOM   4431 C  C   . CYS B 1 273 ? 24.94136 9.29182   -83.34452  1.000 24.46105  ? 231 CYS B C   1 
ATOM   4432 O  O   . CYS B 1 273 ? 23.81516 9.78963   -83.35200  1.000 24.50344  ? 231 CYS B O   1 
ATOM   4433 C  CB  . CYS B 1 273 ? 25.79981 7.02314   -82.62215  1.000 15.65339  ? 231 CYS B CB  1 
ATOM   4434 S  SG  . CYS B 1 273 ? 24.52411 5.75052   -82.58886  1.000 22.84745  ? 231 CYS B SG  1 
ATOM   4435 N  N   . ALA B 1 274 ? 25.78968 9.48823   -84.34888  1.000 18.74805  ? 232 ALA B N   1 
ATOM   4436 C  CA  . ALA B 1 274 ? 25.48199 10.43821  -85.41605  1.000 24.79365  ? 232 ALA B CA  1 
ATOM   4437 C  C   . ALA B 1 274 ? 25.50900 9.68609   -86.72973  1.000 25.52888  ? 232 ALA B C   1 
ATOM   4438 O  O   . ALA B 1 274 ? 26.42962 8.89945   -86.95750  1.000 21.50712  ? 232 ALA B O   1 
ATOM   4439 C  CB  . ALA B 1 274 ? 26.49022 11.61481  -85.42853  1.000 15.01155  ? 232 ALA B CB  1 
ATOM   4440 N  N   . CYS B 1 275 ? 24.49923 9.90575   -87.57874  1.000 19.12109  ? 233 CYS B N   1 
ATOM   4441 C  CA  . CYS B 1 275 ? 24.38712 9.20811   -88.85547  1.000 19.68982  ? 233 CYS B CA  1 
ATOM   4442 C  C   . CYS B 1 275 ? 24.48310 10.17976  -90.02575  1.000 24.25967  ? 233 CYS B C   1 
ATOM   4443 O  O   . CYS B 1 275 ? 23.91741 11.27832  -89.98400  1.000 27.08304  ? 233 CYS B O   1 
ATOM   4444 C  CB  . CYS B 1 275 ? 23.08031 8.39498   -88.93852  1.000 19.55203  ? 233 CYS B CB  1 
ATOM   4445 S  SG  . CYS B 1 275 ? 23.00063 7.05312   -87.66171  1.000 30.80722  ? 233 CYS B SG  1 
ATOM   4446 N  N   . VAL B 1 276 ? 25.23183 9.77875   -91.05703  1.000 27.23116  ? 234 VAL B N   1 
ATOM   4447 C  CA  . VAL B 1 276 ? 25.40914 10.54753  -92.29152  1.000 23.38982  ? 234 VAL B CA  1 
ATOM   4448 C  C   . VAL B 1 276 ? 25.39340 9.54497   -93.44828  1.000 25.60270  ? 234 VAL B C   1 
ATOM   4449 O  O   . VAL B 1 276 ? 26.28839 8.68846   -93.54887  1.000 24.31324  ? 234 VAL B O   1 
ATOM   4450 C  CB  . VAL B 1 276 ? 26.71845 11.36690  -92.31263  1.000 26.83536  ? 234 VAL B CB  1 
ATOM   4451 C  CG1 . VAL B 1 276 ? 26.87712 12.08946  -93.63946  1.000 24.08265  ? 234 VAL B CG1 1 
ATOM   4452 C  CG2 . VAL B 1 276 ? 26.78564 12.34315  -91.16104  1.000 29.26606  ? 234 VAL B CG2 1 
ATOM   4453 N  N   . ASN B 1 277 ? 24.36944 9.62735   -94.29704  1.000 21.91689  ? 235 ASN B N   1 
ATOM   4454 C  CA  . ASN B 1 277 ? 24.33370 8.90038   -95.56115  1.000 30.97663  ? 235 ASN B CA  1 
ATOM   4455 C  C   . ASN B 1 277 ? 24.48839 7.38993   -95.36076  1.000 30.41818  ? 235 ASN B C   1 
ATOM   4456 O  O   . ASN B 1 277 ? 25.14240 6.70997   -96.14696  1.000 28.13226  ? 235 ASN B O   1 
ATOM   4457 C  CB  . ASN B 1 277 ? 25.41086 9.42026   -96.52255  1.000 30.98217  ? 235 ASN B CB  1 
ATOM   4458 C  CG  . ASN B 1 277 ? 25.22697 8.88877   -97.94863  1.000 38.71961  ? 235 ASN B CG  1 
ATOM   4459 O  OD1 . ASN B 1 277 ? 24.08932 8.69850   -98.39447  1.000 38.90653  ? 235 ASN B OD1 1 
ATOM   4460 N  ND2 . ASN B 1 277 ? 26.33971 8.60464   -98.64722  1.000 42.82546  ? 235 ASN B ND2 1 
ATOM   4461 N  N   . GLY B 1 278 ? 23.88615 6.84894   -94.31148  1.000 24.75787  ? 236 GLY B N   1 
ATOM   4462 C  CA  . GLY B 1 278 ? 23.93054 5.40618   -94.11486  1.000 26.13674  ? 236 GLY B CA  1 
ATOM   4463 C  C   . GLY B 1 278 ? 25.06669 4.90235   -93.24977  1.000 30.42682  ? 236 GLY B C   1 
ATOM   4464 O  O   . GLY B 1 278 ? 25.12028 3.69760   -92.95468  1.000 28.55394  ? 236 GLY B O   1 
ATOM   4465 N  N   . SER B 1 279 ? 25.97195 5.77458   -92.81683  1.000 24.82865  ? 237 SER B N   1 
ATOM   4466 C  CA  . SER B 1 279 ? 26.99291 5.39799   -91.85308  1.000 18.44347  ? 237 SER B CA  1 
ATOM   4467 C  C   . SER B 1 279 ? 26.72431 6.12778   -90.55179  1.000 28.35069  ? 237 SER B C   1 
ATOM   4468 O  O   . SER B 1 279 ? 26.43971 7.33884   -90.54402  1.000 26.03795  ? 237 SER B O   1 
ATOM   4469 C  CB  . SER B 1 279 ? 28.40122 5.74690   -92.35546  1.000 22.26527  ? 237 SER B CB  1 
ATOM   4470 O  OG  . SER B 1 279 ? 28.48788 5.46292   -93.73976  1.000 28.93390  ? 237 SER B OG  1 
ATOM   4471 N  N   . CYS B 1 280 ? 26.82602 5.39023   -89.45882  1.000 19.64367  ? 238 CYS B N   1 
ATOM   4472 C  CA  . CYS B 1 280 ? 26.64304 5.93971   -88.13497  1.000 24.35826  ? 238 CYS B CA  1 
ATOM   4473 C  C   . CYS B 1 280 ? 27.96583 5.83509   -87.39195  1.000 28.98942  ? 238 CYS B C   1 
ATOM   4474 O  O   . CYS B 1 280 ? 28.77570 4.91568   -87.62276  1.000 22.03155  ? 238 CYS B O   1 
ATOM   4475 C  CB  . CYS B 1 280 ? 25.52025 5.20916   -87.40545  1.000 26.43509  ? 238 CYS B CB  1 
ATOM   4476 S  SG  . CYS B 1 280 ? 23.93595 5.31612   -88.34374  1.000 32.04903  ? 238 CYS B SG  1 
ATOM   4477 N  N   . PHE B 1 281 ? 28.19723 6.81788   -86.52685  1.000 23.45588  ? 239 PHE B N   1 
ATOM   4478 C  CA  . PHE B 1 281 ? 29.52572 7.04930   -85.98285  1.000 20.10235  ? 239 PHE B CA  1 
ATOM   4479 C  C   . PHE B 1 281 ? 29.40397 7.19996   -84.48085  1.000 25.48624  ? 239 PHE B C   1 
ATOM   4480 O  O   . PHE B 1 281 ? 28.43476 7.79011   -83.97960  1.000 23.21819  ? 239 PHE B O   1 
ATOM   4481 C  CB  . PHE B 1 281 ? 30.16264 8.30219   -86.58893  1.000 19.74255  ? 239 PHE B CB  1 
ATOM   4482 C  CG  . PHE B 1 281 ? 30.31082 8.25356   -88.09256  1.000 21.21321  ? 239 PHE B CG  1 
ATOM   4483 C  CD1 . PHE B 1 281 ? 29.28231 8.67364   -88.92077  1.000 17.86803  ? 239 PHE B CD1 1 
ATOM   4484 C  CD2 . PHE B 1 281 ? 31.50702 7.81840   -88.67350  1.000 23.54907  ? 239 PHE B CD2 1 
ATOM   4485 C  CE1 . PHE B 1 281 ? 29.41264 8.66397   -90.29796  1.000 18.19747  ? 239 PHE B CE1 1 
ATOM   4486 C  CE2 . PHE B 1 281 ? 31.65248 7.79525   -90.06367  1.000 18.22985  ? 239 PHE B CE2 1 
ATOM   4487 C  CZ  . PHE B 1 281 ? 30.60566 8.23460   -90.87448  1.000 20.14905  ? 239 PHE B CZ  1 
ATOM   4488 N  N   . THR B 1 282 ? 30.35770 6.63387   -83.76145  1.000 16.28917  ? 240 THR B N   1 
ATOM   4489 C  CA  . THR B 1 282 ? 30.37429 6.81051   -82.32269  1.000 20.43769  ? 240 THR B CA  1 
ATOM   4490 C  C   . THR B 1 282 ? 31.82204 6.83976   -81.83602  1.000 20.43791  ? 240 THR B C   1 
ATOM   4491 O  O   . THR B 1 282 ? 32.76752 6.64623   -82.60464  1.000 22.64268  ? 240 THR B O   1 
ATOM   4492 C  CB  . THR B 1 282 ? 29.51814 5.74603   -81.63576  1.000 17.70933  ? 240 THR B CB  1 
ATOM   4493 O  OG1 . THR B 1 282 ? 29.39226 6.09588   -80.25149  1.000 21.33983  ? 240 THR B OG1 1 
ATOM   4494 C  CG2 . THR B 1 282 ? 30.16319 4.36296   -81.76891  1.000 18.62270  ? 240 THR B CG2 1 
ATOM   4495 N  N   . VAL B 1 283 ? 31.98835 7.17992   -80.56366  1.000 23.14134  ? 241 VAL B N   1 
ATOM   4496 C  CA  . VAL B 1 283 ? 33.29029 7.24285   -79.91139  1.000 22.11477  ? 241 VAL B CA  1 
ATOM   4497 C  C   . VAL B 1 283 ? 33.21367 6.39417   -78.65981  1.000 19.61684  ? 241 VAL B C   1 
ATOM   4498 O  O   . VAL B 1 283 ? 32.20186 6.42817   -77.94124  1.000 18.89050  ? 241 VAL B O   1 
ATOM   4499 C  CB  . VAL B 1 283 ? 33.70152 8.69016   -79.54880  1.000 18.10493  ? 241 VAL B CB  1 
ATOM   4500 C  CG1 . VAL B 1 283 ? 35.12372 8.68309   -78.87580  1.000 19.33179  ? 241 VAL B CG1 1 
ATOM   4501 C  CG2 . VAL B 1 283 ? 33.66182 9.57455   -80.77572  1.000 18.56830  ? 241 VAL B CG2 1 
ATOM   4502 N  N   . MET B 1 284 ? 34.26264 5.59991   -78.41747  1.000 18.36215  ? 242 MET B N   1 
ATOM   4503 C  CA  . MET B 1 284 ? 34.36923 4.81766   -77.19754  1.000 14.54091  ? 242 MET B CA  1 
ATOM   4504 C  C   . MET B 1 284 ? 35.71769 5.04394   -76.54424  1.000 16.30918  ? 242 MET B C   1 
ATOM   4505 O  O   . MET B 1 284 ? 36.69509 5.39623   -77.20551  1.000 16.24445  ? 242 MET B O   1 
ATOM   4506 C  CB  . MET B 1 284 ? 34.17506 3.28524   -77.44508  1.000 19.60258  ? 242 MET B CB  1 
ATOM   4507 C  CG  . MET B 1 284 ? 32.89547 2.94929   -78.14615  1.000 20.76874  ? 242 MET B CG  1 
ATOM   4508 S  SD  . MET B 1 284 ? 32.54236 1.16438   -78.23212  1.000 27.15983  ? 242 MET B SD  1 
ATOM   4509 C  CE  . MET B 1 284 ? 31.09941 1.18438   -79.31065  1.000 21.68220  ? 242 MET B CE  1 
ATOM   4510 N  N   . THR B 1 285 ? 35.75784 4.82774   -75.23466  1.000 14.89462  ? 243 THR B N   1 
ATOM   4511 C  CA  . THR B 1 285 ? 36.97466 4.97792   -74.45072  1.000 18.17170  ? 243 THR B CA  1 
ATOM   4512 C  C   . THR B 1 285 ? 37.25270 3.68810   -73.68977  1.000 17.72332  ? 243 THR B C   1 
ATOM   4513 O  O   . THR B 1 285 ? 36.32736 2.99762   -73.25690  1.000 16.80915  ? 243 THR B O   1 
ATOM   4514 C  CB  . THR B 1 285 ? 36.80926 6.14498   -73.50668  1.000 22.22345  ? 243 THR B CB  1 
ATOM   4515 O  OG1 . THR B 1 285 ? 36.55635 7.28798   -74.31513  1.000 21.77465  ? 243 THR B OG1 1 
ATOM   4516 C  CG2 . THR B 1 285 ? 38.04206 6.37222   -72.65792  1.000 17.77742  ? 243 THR B CG2 1 
ATOM   4517 N  N   . ASP B 1 286 ? 38.52641 3.34491   -73.54890  1.000 11.63888  ? 244 ASP B N   1 
ATOM   4518 C  CA  . ASP B 1 286 ? 38.94796 2.22443   -72.72285  1.000 17.63738  ? 244 ASP B CA  1 
ATOM   4519 C  C   . ASP B 1 286 ? 40.23651 2.65536   -72.04069  1.000 22.81550  ? 244 ASP B C   1 
ATOM   4520 O  O   . ASP B 1 286 ? 41.15311 3.13155   -72.71283  1.000 21.85509  ? 244 ASP B O   1 
ATOM   4521 C  CB  . ASP B 1 286 ? 39.15081 0.99498   -73.60076  1.000 14.87359  ? 244 ASP B CB  1 
ATOM   4522 C  CG  . ASP B 1 286 ? 39.15660 -0.31843  -72.83319  1.000 22.20936  ? 244 ASP B CG  1 
ATOM   4523 O  OD1 . ASP B 1 286 ? 39.31358 -0.38149  -71.59230  1.000 21.36702  ? 244 ASP B OD1 1 
ATOM   4524 O  OD2 . ASP B 1 286 ? 38.99531 -1.32211  -73.53481  1.000 19.17189  ? 244 ASP B OD2 1 
ATOM   4525 N  N   . GLY B 1 287 ? 40.27494 2.56235   -70.71877  1.000 23.68575  ? 245 GLY B N   1 
ATOM   4526 C  CA  . GLY B 1 287 ? 41.39471 3.03871   -69.94908  1.000 20.59298  ? 245 GLY B CA  1 
ATOM   4527 C  C   . GLY B 1 287 ? 40.98995 3.88343   -68.74966  1.000 24.26877  ? 245 GLY B C   1 
ATOM   4528 O  O   . GLY B 1 287 ? 39.79883 4.03537   -68.40755  1.000 19.71411  ? 245 GLY B O   1 
ATOM   4529 N  N   . PRO B 1 288 ? 41.99923 4.45053   -68.08316  1.000 19.43976  ? 246 PRO B N   1 
ATOM   4530 C  CA  . PRO B 1 288 ? 41.74370 5.22753   -66.86844  1.000 21.79166  ? 246 PRO B CA  1 
ATOM   4531 C  C   . PRO B 1 288 ? 40.74787 6.34837   -67.09520  1.000 15.89674  ? 246 PRO B C   1 
ATOM   4532 O  O   . PRO B 1 288 ? 40.60754 6.88713   -68.19422  1.000 18.80348  ? 246 PRO B O   1 
ATOM   4533 C  CB  . PRO B 1 288 ? 43.12706 5.78716   -66.51025  1.000 21.66651  ? 246 PRO B CB  1 
ATOM   4534 C  CG  . PRO B 1 288 ? 44.05962 4.79585   -67.07427  1.000 21.05115  ? 246 PRO B CG  1 
ATOM   4535 C  CD  . PRO B 1 288 ? 43.44705 4.30149   -68.34113  1.000 19.15850  ? 246 PRO B CD  1 
ATOM   4536 N  N   . SER B 1 289 ? 40.04493 6.68917   -66.03606  1.000 19.20502  ? 247 SER B N   1 
ATOM   4537 C  CA  . SER B 1 289 ? 39.23033 7.89382   -66.04761  1.000 26.51047  ? 247 SER B CA  1 
ATOM   4538 C  C   . SER B 1 289 ? 39.94966 9.04812   -65.36401  1.000 26.66152  ? 247 SER B C   1 
ATOM   4539 O  O   . SER B 1 289 ? 39.42912 10.16601  -65.30683  1.000 24.03594  ? 247 SER B O   1 
ATOM   4540 C  CB  . SER B 1 289 ? 37.87366 7.62565   -65.38348  1.000 26.81435  ? 247 SER B CB  1 
ATOM   4541 O  OG  . SER B 1 289 ? 38.06126 7.16346   -64.05692  1.000 30.17775  ? 247 SER B OG  1 
ATOM   4542 N  N   . ASN B 1 290 ? 41.13061 8.79419   -64.83695  1.000 22.45453  ? 248 ASN B N   1 
ATOM   4543 C  CA  . ASN B 1 290 ? 41.90369 9.80647   -64.14635  1.000 20.01681  ? 248 ASN B CA  1 
ATOM   4544 C  C   . ASN B 1 290 ? 43.29487 9.87645   -64.73781  1.000 22.83610  ? 248 ASN B C   1 
ATOM   4545 O  O   . ASN B 1 290 ? 44.25346 10.11525  -64.01535  1.000 23.22589  ? 248 ASN B O   1 
ATOM   4546 C  CB  . ASN B 1 290 ? 41.97834 9.51604   -62.64992  1.000 20.72547  ? 248 ASN B CB  1 
ATOM   4547 C  CG  . ASN B 1 290 ? 42.71478 8.22317   -62.34706  1.000 26.78346  ? 248 ASN B CG  1 
ATOM   4548 O  OD1 . ASN B 1 290 ? 42.94032 7.39813   -63.23375  1.000 19.38839  ? 248 ASN B OD1 1 
ATOM   4549 N  ND2 . ASN B 1 290 ? 43.08946 8.03875   -61.09329  1.000 23.45163  ? 248 ASN B ND2 1 
ATOM   4550 N  N   . GLY B 1 291 ? 43.42269 9.60607   -66.03087  1.000 21.45037  ? 249 GLY B N   1 
ATOM   4551 C  CA  . GLY B 1 291 ? 44.73110 9.59369   -66.66226  1.000 16.38044  ? 249 GLY B CA  1 
ATOM   4552 C  C   . GLY B 1 291 ? 44.55954 9.36131   -68.14021  1.000 18.45696  ? 249 GLY B C   1 
ATOM   4553 O  O   . GLY B 1 291 ? 43.43792 9.23232   -68.64145  1.000 20.84715  ? 249 GLY B O   1 
ATOM   4554 N  N   . GLN B 1 292 ? 45.69019 9.35746   -68.84553  1.000 17.48508  ? 250 GLN B N   1 
ATOM   4555 C  CA  . GLN B 1 292 ? 45.67115 9.05976   -70.26915  1.000 18.28786  ? 250 GLN B CA  1 
ATOM   4556 C  C   . GLN B 1 292 ? 44.90740 7.76217   -70.51742  1.000 25.44205  ? 250 GLN B C   1 
ATOM   4557 O  O   . GLN B 1 292 ? 45.11032 6.75747   -69.81928  1.000 15.52395  ? 250 GLN B O   1 
ATOM   4558 C  CB  . GLN B 1 292 ? 47.10151 8.92854   -70.81208  1.000 18.47955  ? 250 GLN B CB  1 
ATOM   4559 C  CG  . GLN B 1 292 ? 47.13568 8.73222   -72.33147  1.000 18.48801  ? 250 GLN B CG  1 
ATOM   4560 C  CD  . GLN B 1 292 ? 46.82676 10.03242  -73.08794  1.000 26.46747  ? 250 GLN B CD  1 
ATOM   4561 O  OE1 . GLN B 1 292 ? 47.43636 11.07398  -72.82114  1.000 22.50679  ? 250 GLN B OE1 1 
ATOM   4562 N  NE2 . GLN B 1 292 ? 45.89144 9.97400   -74.04165  1.000 23.69258  ? 250 GLN B NE2 1 
ATOM   4563 N  N   . ALA B 1 293 ? 44.00112 7.80003   -71.49834  1.000 22.42196  ? 251 ALA B N   1 
ATOM   4564 C  CA  . ALA B 1 293 ? 43.25252 6.60365   -71.86465  1.000 18.13236  ? 251 ALA B CA  1 
ATOM   4565 C  C   . ALA B 1 293 ? 43.29390 6.46338   -73.37931  1.000 19.69217  ? 251 ALA B C   1 
ATOM   4566 O  O   . ALA B 1 293 ? 44.03873 7.16993   -74.06350  1.000 23.04941  ? 251 ALA B O   1 
ATOM   4567 C  CB  . ALA B 1 293 ? 41.80621 6.66854   -71.33324  1.000 15.74744  ? 251 ALA B CB  1 
ATOM   4568 N  N   . SER B 1 294 ? 42.49164 5.56566   -73.91506  1.000 20.39285  ? 252 SER B N   1 
ATOM   4569 C  CA  . SER B 1 294 ? 42.47135 5.28105   -75.33908  1.000 18.64344  ? 252 SER B CA  1 
ATOM   4570 C  C   . SER B 1 294 ? 41.08523 5.64182   -75.86084  1.000 20.33691  ? 252 SER B C   1 
ATOM   4571 O  O   . SER B 1 294 ? 40.08813 5.37204   -75.19302  1.000 22.63958  ? 252 SER B O   1 
ATOM   4572 C  CB  . SER B 1 294 ? 42.82001 3.77339   -75.55075  1.000 22.25810  ? 252 SER B CB  1 
ATOM   4573 O  OG  . SER B 1 294 ? 42.88550 3.42753   -76.91127  1.000 29.19578  ? 252 SER B OG  1 
ATOM   4574 N  N   . TYR B 1 295 ? 41.02007 6.27253   -77.02929  1.000 15.28437  ? 253 TYR B N   1 
ATOM   4575 C  CA  . TYR B 1 295 ? 39.77383 6.77427   -77.59160  1.000 20.48863  ? 253 TYR B CA  1 
ATOM   4576 C  C   . TYR B 1 295 ? 39.70816 6.29921   -79.02627  1.000 17.93373  ? 253 TYR B C   1 
ATOM   4577 O  O   . TYR B 1 295 ? 40.64858 6.52315   -79.78924  1.000 18.65324  ? 253 TYR B O   1 
ATOM   4578 C  CB  . TYR B 1 295 ? 39.69933 8.33215   -77.52368  1.000 19.11705  ? 253 TYR B CB  1 
ATOM   4579 C  CG  . TYR B 1 295 ? 40.45416 8.84776   -76.33772  1.000 15.49129  ? 253 TYR B CG  1 
ATOM   4580 C  CD1 . TYR B 1 295 ? 39.97312 8.63400   -75.05227  1.000 15.15259  ? 253 TYR B CD1 1 
ATOM   4581 C  CD2 . TYR B 1 295 ? 41.69028 9.50933   -76.49149  1.000 17.46617  ? 253 TYR B CD2 1 
ATOM   4582 C  CE1 . TYR B 1 295 ? 40.68972 9.05105   -73.95815  1.000 14.60415  ? 253 TYR B CE1 1 
ATOM   4583 C  CE2 . TYR B 1 295 ? 42.40351 9.96531   -75.39162  1.000 14.38280  ? 253 TYR B CE2 1 
ATOM   4584 C  CZ  . TYR B 1 295 ? 41.90559 9.72154   -74.13518  1.000 19.00689  ? 253 TYR B CZ  1 
ATOM   4585 O  OH  . TYR B 1 295 ? 42.61626 10.13261  -73.03398  1.000 15.28936  ? 253 TYR B OH  1 
ATOM   4586 N  N   . LYS B 1 296 ? 38.61198 5.64099   -79.40237  1.000 18.52719  ? 254 LYS B N   1 
ATOM   4587 C  CA  . LYS B 1 296 ? 38.45372 5.13737   -80.76354  1.000 18.92886  ? 254 LYS B CA  1 
ATOM   4588 C  C   . LYS B 1 296 ? 37.18048 5.67951   -81.37233  1.000 18.29799  ? 254 LYS B C   1 
ATOM   4589 O  O   . LYS B 1 296 ? 36.14167 5.70334   -80.70887  1.000 18.66311  ? 254 LYS B O   1 
ATOM   4590 C  CB  . LYS B 1 296 ? 38.37702 3.59326   -80.83235  1.000 15.25526  ? 254 LYS B CB  1 
ATOM   4591 C  CG  . LYS B 1 296 ? 39.71822 2.83569   -80.66318  1.000 25.65499  ? 254 LYS B CG  1 
ATOM   4592 C  CD  . LYS B 1 296 ? 39.53201 1.36412   -81.13014  1.000 18.03384  ? 254 LYS B CD  1 
ATOM   4593 C  CE  . LYS B 1 296 ? 40.83539 0.55584   -80.98902  1.000 27.55898  ? 254 LYS B CE  1 
ATOM   4594 N  NZ  . LYS B 1 296 ? 40.61550 -0.85484  -81.40006  1.000 28.91442  ? 254 LYS B NZ  1 
ATOM   4595 N  N   . ILE B 1 297 ? 37.24881 6.00275   -82.66325  1.000 19.12369  ? 255 ILE B N   1 
ATOM   4596 C  CA  . ILE B 1 297 ? 36.08456 6.36832   -83.45866  1.000 21.30340  ? 255 ILE B CA  1 
ATOM   4597 C  C   . ILE B 1 297 ? 35.65819 5.15843   -84.26931  1.000 21.48636  ? 255 ILE B C   1 
ATOM   4598 O  O   . ILE B 1 297 ? 36.50145 4.49449   -84.89121  1.000 21.60651  ? 255 ILE B O   1 
ATOM   4599 C  CB  . ILE B 1 297 ? 36.39774 7.54106   -84.39573  1.000 20.40654  ? 255 ILE B CB  1 
ATOM   4600 C  CG1 . ILE B 1 297 ? 37.06723 8.68388   -83.62513  1.000 26.83488  ? 255 ILE B CG1 1 
ATOM   4601 C  CG2 . ILE B 1 297 ? 35.11307 8.01522   -85.08333  1.000 22.20262  ? 255 ILE B CG2 1 
ATOM   4602 C  CD1 . ILE B 1 297 ? 37.76461 9.65474   -84.54445  1.000 20.19956  ? 255 ILE B CD1 1 
ATOM   4603 N  N   . PHE B 1 298 ? 34.35448 4.88514   -84.29393  1.000 18.21014  ? 256 PHE B N   1 
ATOM   4604 C  CA  . PHE B 1 298 ? 33.79356 3.76673   -85.03559  1.000 17.68835  ? 256 PHE B CA  1 
ATOM   4605 C  C   . PHE B 1 298 ? 32.86356 4.24507   -86.14148  1.000 21.81147  ? 256 PHE B C   1 
ATOM   4606 O  O   . PHE B 1 298 ? 32.04387 5.14293   -85.94267  1.000 25.69449  ? 256 PHE B O   1 
ATOM   4607 C  CB  . PHE B 1 298 ? 33.04237 2.82319   -84.10445  1.000 18.45529  ? 256 PHE B CB  1 
ATOM   4608 C  CG  . PHE B 1 298 ? 33.92835 2.10372   -83.16253  1.000 20.56695  ? 256 PHE B CG  1 
ATOM   4609 C  CD1 . PHE B 1 298 ? 34.44319 0.85165   -83.49397  1.000 24.51681  ? 256 PHE B CD1 1 
ATOM   4610 C  CD2 . PHE B 1 298 ? 34.29411 2.67752   -81.95036  1.000 21.69983  ? 256 PHE B CD2 1 
ATOM   4611 C  CE1 . PHE B 1 298 ? 35.28351 0.16911   -82.63549  1.000 20.64485  ? 256 PHE B CE1 1 
ATOM   4612 C  CE2 . PHE B 1 298 ? 35.15251 1.98982   -81.07295  1.000 22.68522  ? 256 PHE B CE2 1 
ATOM   4613 C  CZ  . PHE B 1 298 ? 35.65063 0.72606   -81.43929  1.000 19.36486  ? 256 PHE B CZ  1 
ATOM   4614 N  N   . LYS B 1 299 ? 32.99915 3.63836   -87.30948  1.000 21.35436  ? 257 LYS B N   1 
ATOM   4615 C  CA  . LYS B 1 299 ? 32.06072 3.82058   -88.40305  1.000 20.08365  ? 257 LYS B CA  1 
ATOM   4616 C  C   . LYS B 1 299 ? 31.27725 2.51219   -88.54468  1.000 28.12150  ? 257 LYS B C   1 
ATOM   4617 O  O   . LYS B 1 299 ? 31.88282 1.44073   -88.64361  1.000 20.57528  ? 257 LYS B O   1 
ATOM   4618 C  CB  . LYS B 1 299 ? 32.80976 4.17163   -89.67947  1.000 12.68943  ? 257 LYS B CB  1 
ATOM   4619 C  CG  . LYS B 1 299 ? 31.94945 4.46524   -90.85193  1.000 17.63887  ? 257 LYS B CG  1 
ATOM   4620 C  CD  . LYS B 1 299 ? 32.82335 4.62949   -92.06295  1.000 21.68971  ? 257 LYS B CD  1 
ATOM   4621 C  CE  . LYS B 1 299 ? 32.02096 4.97571   -93.29436  1.000 26.65596  ? 257 LYS B CE  1 
ATOM   4622 N  NZ  . LYS B 1 299 ? 32.98221 5.11306   -94.42749  1.000 23.35786  ? 257 LYS B NZ  1 
ATOM   4623 N  N   . ILE B 1 300 ? 29.94180 2.59341   -88.52161  1.000 19.20507  ? 258 ILE B N   1 
ATOM   4624 C  CA  . ILE B 1 300 ? 29.07088 1.41407   -88.46775  1.000 23.35783  ? 258 ILE B CA  1 
ATOM   4625 C  C   . ILE B 1 300 ? 28.00873 1.51483   -89.55336  1.000 21.73744  ? 258 ILE B C   1 
ATOM   4626 O  O   . ILE B 1 300 ? 27.26954 2.50630   -89.61110  1.000 26.19940  ? 258 ILE B O   1 
ATOM   4627 C  CB  . ILE B 1 300 ? 28.40017 1.29139   -87.08731  1.000 16.78088  ? 258 ILE B CB  1 
ATOM   4628 C  CG1 . ILE B 1 300 ? 29.50011 1.23881   -86.01758  1.000 21.49012  ? 258 ILE B CG1 1 
ATOM   4629 C  CG2 . ILE B 1 300 ? 27.45391 0.12166   -87.06850  1.000 20.17143  ? 258 ILE B CG2 1 
ATOM   4630 C  CD1 . ILE B 1 300 ? 29.02093 1.29039   -84.59346  1.000 20.78936  ? 258 ILE B CD1 1 
ATOM   4631 N  N   . GLU B 1 301 ? 27.89697 0.48380   -90.38335  1.000 20.53622  ? 259 GLU B N   1 
ATOM   4632 C  CA  . GLU B 1 301 ? 26.90042 0.45617   -91.44541  1.000 20.17117  ? 259 GLU B CA  1 
ATOM   4633 C  C   . GLU B 1 301 ? 26.01231 -0.76589  -91.29867  1.000 23.38516  ? 259 GLU B C   1 
ATOM   4634 O  O   . GLU B 1 301 ? 26.49755 -1.90914  -91.29125  1.000 18.38722  ? 259 GLU B O   1 
ATOM   4635 C  CB  . GLU B 1 301 ? 27.55069 0.48793   -92.81919  1.000 22.44440  ? 259 GLU B CB  1 
ATOM   4636 C  CG  . GLU B 1 301 ? 28.15562 1.84966   -93.05328  1.000 29.37100  ? 259 GLU B CG  1 
ATOM   4637 C  CD  . GLU B 1 301 ? 29.05376 1.90230   -94.25241  1.000 34.47349  ? 259 GLU B CD  1 
ATOM   4638 O  OE1 . GLU B 1 301 ? 29.18769 0.85298   -94.93049  1.000 38.60832  ? 259 GLU B OE1 1 
ATOM   4639 O  OE2 . GLU B 1 301 ? 29.61428 3.00318   -94.51194  1.000 32.68982  ? 259 GLU B OE2 1 
ATOM   4640 N  N   . LYS B 1 302 ? 24.70963 -0.51074  -91.20340  1.000 19.05329  ? 260 LYS B N   1 
ATOM   4641 C  CA  . LYS B 1 302 ? 23.71671 -1.55632  -90.97504  1.000 26.57955  ? 260 LYS B CA  1 
ATOM   4642 C  C   . LYS B 1 302 ? 24.10289 -2.40158  -89.77172  1.000 23.14206  ? 260 LYS B C   1 
ATOM   4643 O  O   . LYS B 1 302 ? 23.97311 -3.62389  -89.78083  1.000 18.98607  ? 260 LYS B O   1 
ATOM   4644 C  CB  . LYS B 1 302 ? 23.51380 -2.42123  -92.22427  1.000 23.66241  ? 260 LYS B CB  1 
ATOM   4645 C  CG  . LYS B 1 302 ? 23.08636 -1.59888  -93.42451  1.000 31.72173  ? 260 LYS B CG  1 
ATOM   4646 C  CD  . LYS B 1 302 ? 22.06834 -2.31863  -94.27124  1.000 34.59941  ? 260 LYS B CD  1 
ATOM   4647 C  CE  . LYS B 1 302 ? 21.39914 -1.35174  -95.25771  1.000 45.60160  ? 260 LYS B CE  1 
ATOM   4648 N  NZ  . LYS B 1 302 ? 20.24665 -0.59007  -94.67727  1.000 37.69436  ? 260 LYS B NZ  1 
ATOM   4649 N  N   . GLY B 1 303 ? 24.62386 -1.74517  -88.73824  1.000 20.29918  ? 261 GLY B N   1 
ATOM   4650 C  CA  . GLY B 1 303 ? 25.05575 -2.44136  -87.54210  1.000 17.70409  ? 261 GLY B CA  1 
ATOM   4651 C  C   . GLY B 1 303 ? 26.41322 -3.13400  -87.62084  1.000 19.52398  ? 261 GLY B C   1 
ATOM   4652 O  O   . GLY B 1 303 ? 26.84323 -3.70255  -86.61862  1.000 21.68403  ? 261 GLY B O   1 
ATOM   4653 N  N   . LYS B 1 304 ? 27.10731 -3.09875  -88.75568  1.000 21.77757  ? 262 LYS B N   1 
ATOM   4654 C  CA  . LYS B 1 304 ? 28.45192 -3.67138  -88.87162  1.000 22.81637  ? 262 LYS B CA  1 
ATOM   4655 C  C   . LYS B 1 304 ? 29.53163 -2.59642  -88.74822  1.000 21.90770  ? 262 LYS B C   1 
ATOM   4656 O  O   . LYS B 1 304 ? 29.51018 -1.60594  -89.49012  1.000 25.92577  ? 262 LYS B O   1 
ATOM   4657 C  CB  . LYS B 1 304 ? 28.61477 -4.36515  -90.21930  1.000 22.67071  ? 262 LYS B CB  1 
ATOM   4658 C  CG  . LYS B 1 304 ? 27.67918 -5.54660  -90.40192  1.000 41.97059  ? 262 LYS B CG  1 
ATOM   4659 C  CD  . LYS B 1 304 ? 27.83248 -6.46869  -89.21663  1.000 49.57473  ? 262 LYS B CD  1 
ATOM   4660 C  CE  . LYS B 1 304 ? 27.79842 -7.95048  -89.56484  1.000 51.28868  ? 262 LYS B CE  1 
ATOM   4661 N  NZ  . LYS B 1 304 ? 28.66309 -8.69016  -88.56935  1.000 44.02750  ? 262 LYS B NZ  1 
ATOM   4662 N  N   . VAL B 1 305 ? 30.49906 -2.80705  -87.85601  1.000 26.38781  ? 263 VAL B N   1 
ATOM   4663 C  CA  . VAL B 1 305 ? 31.67768 -1.93166  -87.81486  1.000 23.40591  ? 263 VAL B CA  1 
ATOM   4664 C  C   . VAL B 1 305 ? 32.45397 -2.11473  -89.11346  1.000 22.51463  ? 263 VAL B C   1 
ATOM   4665 O  O   . VAL B 1 305 ? 33.01669 -3.18777  -89.35248  1.000 29.00297  ? 263 VAL B O   1 
ATOM   4666 C  CB  . VAL B 1 305 ? 32.57734 -2.22777  -86.61482  1.000 19.03662  ? 263 VAL B CB  1 
ATOM   4667 C  CG1 . VAL B 1 305 ? 33.81525 -1.34518  -86.67926  1.000 25.01844  ? 263 VAL B CG1 1 
ATOM   4668 C  CG2 . VAL B 1 305 ? 31.82338 -2.03098  -85.29767  1.000 26.19265  ? 263 VAL B CG2 1 
ATOM   4669 N  N   . VAL B 1 306 ? 32.49928 -1.06997  -89.94786  1.000 19.81991  ? 264 VAL B N   1 
ATOM   4670 C  CA  . VAL B 1 306 ? 33.23861 -1.12072  -91.20597  1.000 18.88365  ? 264 VAL B CA  1 
ATOM   4671 C  C   . VAL B 1 306 ? 34.61033 -0.43503  -91.11742  1.000 23.47235  ? 264 VAL B C   1 
ATOM   4672 O  O   . VAL B 1 306 ? 35.46445 -0.67670  -91.98075  1.000 29.24605  ? 264 VAL B O   1 
ATOM   4673 C  CB  . VAL B 1 306 ? 32.40908 -0.51353  -92.35844  1.000 26.45532  ? 264 VAL B CB  1 
ATOM   4674 C  CG1 . VAL B 1 306 ? 31.17214 -1.34998  -92.60912  1.000 17.65167  ? 264 VAL B CG1 1 
ATOM   4675 C  CG2 . VAL B 1 306 ? 32.01369 0.95312   -92.05573  1.000 24.85308  ? 264 VAL B CG2 1 
ATOM   4676 N  N   . LYS B 1 307 ? 34.84587 0.39814   -90.10896  1.000 24.72022  ? 265 LYS B N   1 
ATOM   4677 C  CA  . LYS B 1 307 ? 36.13389 1.05861   -89.92181  1.000 21.19256  ? 265 LYS B CA  1 
ATOM   4678 C  C   . LYS B 1 307 ? 36.18289 1.56961   -88.49437  1.000 24.51489  ? 265 LYS B C   1 
ATOM   4679 O  O   . LYS B 1 307 ? 35.14765 1.86873   -87.89506  1.000 23.61678  ? 265 LYS B O   1 
ATOM   4680 C  CB  . LYS B 1 307 ? 36.35079 2.20637   -90.92021  1.000 17.19056  ? 265 LYS B CB  1 
ATOM   4681 C  CG  . LYS B 1 307 ? 37.79057 2.69315   -90.99696  1.000 22.56297  ? 265 LYS B CG  1 
ATOM   4682 C  CD  . LYS B 1 307 ? 37.94887 3.82375   -92.01139  1.000 25.09268  ? 265 LYS B CD  1 
ATOM   4683 C  CE  . LYS B 1 307 ? 39.42556 4.01828   -92.38494  1.000 32.75287  ? 265 LYS B CE  1 
ATOM   4684 N  NZ  . LYS B 1 307 ? 39.49071 4.82424   -93.60075  1.000 33.41390  ? 265 LYS B NZ  1 
ATOM   4685 N  N   . SER B 1 308 ? 37.38050 1.57238   -87.92881  1.000 22.38445  ? 266 SER B N   1 
ATOM   4686 C  CA  . SER B 1 308 ? 37.64848 2.23353   -86.66506  1.000 20.65960  ? 266 SER B CA  1 
ATOM   4687 C  C   . SER B 1 308 ? 39.03424 2.86226   -86.74540  1.000 28.33316  ? 266 SER B C   1 
ATOM   4688 O  O   . SER B 1 308 ? 39.86052 2.48238   -87.57817  1.000 23.25127  ? 266 SER B O   1 
ATOM   4689 C  CB  . SER B 1 308 ? 37.54666 1.26663   -85.48007  1.000 22.11530  ? 266 SER B CB  1 
ATOM   4690 O  OG  . SER B 1 308 ? 38.49018 0.22658   -85.61030  1.000 29.83342  ? 266 SER B OG  1 
ATOM   4691 N  N   . VAL B 1 309 ? 39.25762 3.86974   -85.90682  1.000 21.00885  ? 267 VAL B N   1 
ATOM   4692 C  CA  . VAL B 1 309 ? 40.54792 4.54083   -85.80258  1.000 32.34571  ? 267 VAL B CA  1 
ATOM   4693 C  C   . VAL B 1 309 ? 40.78700 4.85327   -84.33649  1.000 35.32086  ? 267 VAL B C   1 
ATOM   4694 O  O   . VAL B 1 309 ? 39.89180 5.37925   -83.65541  1.000 22.00599  ? 267 VAL B O   1 
ATOM   4695 C  CB  . VAL B 1 309 ? 40.61702 5.83639   -86.63759  1.000 32.48810  ? 267 VAL B CB  1 
ATOM   4696 C  CG1 . VAL B 1 309 ? 41.84986 6.59545   -86.25570  1.000 39.34449  ? 267 VAL B CG1 1 
ATOM   4697 C  CG2 . VAL B 1 309 ? 40.69639 5.50527   -88.11607  1.000 31.12100  ? 267 VAL B CG2 1 
ATOM   4698 N  N   . GLU B 1 310 ? 41.99238 4.53417   -83.84738  1.000 21.03288  ? 268 GLU B N   1 
ATOM   4699 C  CA  . GLU B 1 310 ? 42.38493 5.01022   -82.53051  1.000 25.09989  ? 268 GLU B CA  1 
ATOM   4700 C  C   . GLU B 1 310 ? 42.93768 6.44004   -82.63937  1.000 28.77039  ? 268 GLU B C   1 
ATOM   4701 O  O   . GLU B 1 310 ? 43.86308 6.70987   -83.41652  1.000 33.58541  ? 268 GLU B O   1 
ATOM   4702 C  CB  . GLU B 1 310 ? 43.40445 4.06576   -81.88119  1.000 22.44957  ? 268 GLU B CB  1 
ATOM   4703 C  CG  . GLU B 1 310 ? 44.06054 4.69682   -80.63625  1.000 31.88497  ? 268 GLU B CG  1 
ATOM   4704 C  CD  . GLU B 1 310 ? 44.63285 3.69063   -79.63031  1.000 40.41362  ? 268 GLU B CD  1 
ATOM   4705 O  OE1 . GLU B 1 310 ? 44.61159 2.46167   -79.89017  1.000 42.06456  ? 268 GLU B OE1 1 
ATOM   4706 O  OE2 . GLU B 1 310 ? 45.08862 4.14386   -78.55423  1.000 36.96071  ? 268 GLU B OE2 1 
ATOM   4707 N  N   . MET B 1 311 ? 42.36684 7.35265   -81.85378  1.000 24.72183  ? 269 MET B N   1 
ATOM   4708 C  CA  . MET B 1 311 ? 42.81513 8.74414   -81.84526  1.000 26.57767  ? 269 MET B CA  1 
ATOM   4709 C  C   . MET B 1 311 ? 44.18291 8.86578   -81.19607  1.000 28.29608  ? 269 MET B C   1 
ATOM   4710 O  O   . MET B 1 311 ? 44.41604 8.35931   -80.09463  1.000 27.20092  ? 269 MET B O   1 
ATOM   4711 C  CB  . MET B 1 311 ? 41.82263 9.63948   -81.09668  1.000 21.97555  ? 269 MET B CB  1 
ATOM   4712 C  CG  . MET B 1 311 ? 40.53886 9.87925   -81.85375  1.000 26.57631  ? 269 MET B CG  1 
ATOM   4713 S  SD  . MET B 1 311 ? 39.13927 10.15909  -80.75014  1.000 27.52754  ? 269 MET B SD  1 
ATOM   4714 C  CE  . MET B 1 311 ? 39.65818 11.66625  -79.91938  1.000 28.58671  ? 269 MET B CE  1 
ATOM   4715 N  N   . ASN B 1 312 ? 45.07168 9.58363   -81.86062  1.000 22.88775  ? 270 ASN B N   1 
ATOM   4716 C  CA  . ASN B 1 312 ? 46.38013 9.88807   -81.29299  1.000 22.95667  ? 270 ASN B CA  1 
ATOM   4717 C  C   . ASN B 1 312 ? 46.21638 11.22836  -80.58079  1.000 27.42529  ? 270 ASN B C   1 
ATOM   4718 O  O   . ASN B 1 312 ? 46.29157 12.29982  -81.18186  1.000 25.49875  ? 270 ASN B O   1 
ATOM   4719 C  CB  . ASN B 1 312 ? 47.42863 9.91909   -82.39434  1.000 21.76476  ? 270 ASN B CB  1 
ATOM   4720 C  CG  . ASN B 1 312 ? 48.80519 10.22558  -81.86819  1.000 37.98611  ? 270 ASN B CG  1 
ATOM   4721 O  OD1 . ASN B 1 312 ? 49.18882 9.77795   -80.78034  1.000 33.07701  ? 270 ASN B OD1 1 
ATOM   4722 N  ND2 . ASN B 1 312 ? 49.53619 11.04988  -82.60484  1.000 31.90990  ? 270 ASN B ND2 1 
ATOM   4723 N  N   . ALA B 1 313 ? 45.92494 11.17854  -79.28944  1.000 21.77611  ? 271 ALA B N   1 
ATOM   4724 C  CA  . ALA B 1 313 ? 45.47447 12.36368  -78.56312  1.000 21.18238  ? 271 ALA B CA  1 
ATOM   4725 C  C   . ALA B 1 313 ? 46.23912 12.49640  -77.25539  1.000 20.25754  ? 271 ALA B C   1 
ATOM   4726 O  O   . ALA B 1 313 ? 45.64439 12.51423  -76.17478  1.000 12.81034  ? 271 ALA B O   1 
ATOM   4727 C  CB  . ALA B 1 313 ? 43.95663 12.28474  -78.32709  1.000 16.34507  ? 271 ALA B CB  1 
ATOM   4728 N  N   . PRO B 1 314 ? 47.57797 12.61782  -77.30780  1.000 21.62431  ? 272 PRO B N   1 
ATOM   4729 C  CA  . PRO B 1 314 ? 48.33152 12.68505  -76.04698  1.000 18.58831  ? 272 PRO B CA  1 
ATOM   4730 C  C   . PRO B 1 314 ? 47.93240 13.92341  -75.24687  1.000 19.16466  ? 272 PRO B C   1 
ATOM   4731 O  O   . PRO B 1 314 ? 47.82999 15.02135  -75.78934  1.000 22.68741  ? 272 PRO B O   1 
ATOM   4732 C  CB  . PRO B 1 314 ? 49.80819 12.75683  -76.49694  1.000 21.70509  ? 272 PRO B CB  1 
ATOM   4733 C  CG  . PRO B 1 314 ? 49.77484 13.33065  -77.89383  1.000 22.28026  ? 272 PRO B CG  1 
ATOM   4734 C  CD  . PRO B 1 314 ? 48.44448 12.78701  -78.49503  1.000 17.30276  ? 272 PRO B CD  1 
ATOM   4735 N  N   . ASN B 1 315 ? 47.74196 13.73403  -73.93978  1.000 16.86571  ? 273 ASN B N   1 
ATOM   4736 C  CA  . ASN B 1 315 ? 47.37256 14.74060  -72.95210  1.000 23.37807  ? 273 ASN B CA  1 
ATOM   4737 C  C   . ASN B 1 315 ? 45.90343 15.16354  -73.05480  1.000 23.72445  ? 273 ASN B C   1 
ATOM   4738 O  O   . ASN B 1 315 ? 45.48616 16.04248  -72.28814  1.000 20.52405  ? 273 ASN B O   1 
ATOM   4739 C  CB  . ASN B 1 315 ? 48.25000 16.00452  -73.02210  1.000 16.78635  ? 273 ASN B CB  1 
ATOM   4740 C  CG  . ASN B 1 315 ? 48.39942 16.68458  -71.67971  1.000 19.61069  ? 273 ASN B CG  1 
ATOM   4741 O  OD1 . ASN B 1 315 ? 48.74237 16.03956  -70.68635  1.000 23.93426  ? 273 ASN B OD1 1 
ATOM   4742 N  ND2 . ASN B 1 315 ? 48.09469 18.00061  -71.62981  1.000 28.31372  ? 273 ASN B ND2 1 
ATOM   4743 N  N   . TYR B 1 316 ? 45.12289 14.59210  -73.98063  1.000 21.28977  ? 274 TYR B N   1 
ATOM   4744 C  CA  . TYR B 1 316 ? 43.67366 14.76552  -74.05540  1.000 19.77390  ? 274 TYR B CA  1 
ATOM   4745 C  C   . TYR B 1 316 ? 42.95904 13.62863  -73.31240  1.000 25.24165  ? 274 TYR B C   1 
ATOM   4746 O  O   . TYR B 1 316 ? 43.50934 12.53446  -73.12974  1.000 19.33420  ? 274 TYR B O   1 
ATOM   4747 C  CB  . TYR B 1 316 ? 43.21231 14.77154  -75.50669  1.000 19.48618  ? 274 TYR B CB  1 
ATOM   4748 C  CG  . TYR B 1 316 ? 43.56443 16.01763  -76.27567  1.000 31.78170  ? 274 TYR B CG  1 
ATOM   4749 C  CD1 . TYR B 1 316 ? 42.72284 16.49642  -77.28119  1.000 23.11763  ? 274 TYR B CD1 1 
ATOM   4750 C  CD2 . TYR B 1 316 ? 44.72752 16.74892  -75.98999  1.000 35.59410  ? 274 TYR B CD2 1 
ATOM   4751 C  CE1 . TYR B 1 316 ? 43.04749 17.68077  -78.00424  1.000 25.54252  ? 274 TYR B CE1 1 
ATOM   4752 C  CE2 . TYR B 1 316 ? 45.03197 17.91936  -76.68582  1.000 25.31525  ? 274 TYR B CE2 1 
ATOM   4753 C  CZ  . TYR B 1 316 ? 44.20796 18.35832  -77.71075  1.000 28.71221  ? 274 TYR B CZ  1 
ATOM   4754 O  OH  . TYR B 1 316 ? 44.53289 19.51438  -78.39576  1.000 34.18342  ? 274 TYR B OH  1 
ATOM   4755 N  N   . HIS B 1 317 ? 41.72698 13.90066  -72.86094  1.000 20.28578  ? 275 HIS B N   1 
ATOM   4756 C  CA  . HIS B 1 317 ? 40.92117 12.85234  -72.24385  1.000 16.86187  ? 275 HIS B CA  1 
ATOM   4757 C  C   . HIS B 1 317 ? 39.49278 12.94397  -72.76901  1.000 25.09167  ? 275 HIS B C   1 
ATOM   4758 O  O   . HIS B 1 317 ? 38.88365 14.02159  -72.72180  1.000 19.42539  ? 275 HIS B O   1 
ATOM   4759 C  CB  . HIS B 1 317 ? 40.94802 12.95413  -70.72008  1.000 18.33471  ? 275 HIS B CB  1 
ATOM   4760 C  CG  . HIS B 1 317 ? 40.45423 11.71626  -70.03162  1.000 23.07013  ? 275 HIS B CG  1 
ATOM   4761 N  ND1 . HIS B 1 317 ? 39.20878 11.63804  -69.43213  1.000 21.14846  ? 275 HIS B ND1 1 
ATOM   4762 C  CD2 . HIS B 1 317 ? 41.01744 10.48770  -69.89770  1.000 21.78001  ? 275 HIS B CD2 1 
ATOM   4763 C  CE1 . HIS B 1 317 ? 39.04674 10.42727  -68.92826  1.000 21.29794  ? 275 HIS B CE1 1 
ATOM   4764 N  NE2 . HIS B 1 317 ? 40.12617 9.70783   -69.20207  1.000 21.74324  ? 275 HIS B NE2 1 
ATOM   4765 N  N   . TYR B 1 318 ? 38.96898 11.83052  -73.30015  1.000 19.53442  ? 276 TYR B N   1 
ATOM   4766 C  CA  . TYR B 1 318 ? 37.65379 11.81204  -73.94515  1.000 21.50378  ? 276 TYR B CA  1 
ATOM   4767 C  C   . TYR B 1 318 ? 36.74343 10.81450  -73.24390  1.000 21.76617  ? 276 TYR B C   1 
ATOM   4768 O  O   . TYR B 1 318 ? 37.07402 9.62292   -73.13987  1.000 17.53124  ? 276 TYR B O   1 
ATOM   4769 C  CB  . TYR B 1 318 ? 37.75095 11.45291  -75.42959  1.000 18.90990  ? 276 TYR B CB  1 
ATOM   4770 C  CG  . TYR B 1 318 ? 38.33187 12.53899  -76.28765  1.000 19.97300  ? 276 TYR B CG  1 
ATOM   4771 C  CD1 . TYR B 1 318 ? 39.72096 12.66022  -76.44896  1.000 18.62993  ? 276 TYR B CD1 1 
ATOM   4772 C  CD2 . TYR B 1 318 ? 37.50539 13.46919  -76.91607  1.000 19.02670  ? 276 TYR B CD2 1 
ATOM   4773 C  CE1 . TYR B 1 318 ? 40.24967 13.66486  -77.24385  1.000 20.79448  ? 276 TYR B CE1 1 
ATOM   4774 C  CE2 . TYR B 1 318 ? 38.01658 14.46553  -77.70515  1.000 22.92197  ? 276 TYR B CE2 1 
ATOM   4775 C  CZ  . TYR B 1 318 ? 39.40139 14.57297  -77.86512  1.000 22.73356  ? 276 TYR B CZ  1 
ATOM   4776 O  OH  . TYR B 1 318 ? 39.93339 15.59021  -78.65005  1.000 22.21707  ? 276 TYR B OH  1 
ATOM   4777 N  N   . GLU B 1 319 ? 35.58746 11.29477  -72.79977  1.000 21.74008  ? 277 GLU B N   1 
ATOM   4778 C  CA  . GLU B 1 319 ? 34.56430 10.43525  -72.22088  1.000 17.70367  ? 277 GLU B CA  1 
ATOM   4779 C  C   . GLU B 1 319 ? 33.19464 11.00433  -72.53701  1.000 20.86817  ? 277 GLU B C   1 
ATOM   4780 O  O   . GLU B 1 319 ? 33.02403 12.22942  -72.59728  1.000 20.11275  ? 277 GLU B O   1 
ATOM   4781 C  CB  . GLU B 1 319 ? 34.76644 10.33659  -70.71805  1.000 21.99167  ? 277 GLU B CB  1 
ATOM   4782 C  CG  . GLU B 1 319 ? 35.58152 9.09291   -70.30213  1.000 33.09277  ? 277 GLU B CG  1 
ATOM   4783 C  CD  . GLU B 1 319 ? 35.83244 9.12332   -68.82867  1.000 38.05616  ? 277 GLU B CD  1 
ATOM   4784 O  OE1 . GLU B 1 319 ? 35.23521 10.01161  -68.15043  1.000 43.73757  ? 277 GLU B OE1 1 
ATOM   4785 O  OE2 . GLU B 1 319 ? 36.58608 8.27156   -68.34484  1.000 30.39493  ? 277 GLU B OE2 1 
ATOM   4786 N  N   . GLU B 1 320 ? 32.21469 10.11319  -72.70444  1.000 18.25409  ? 278 GLU B N   1 
ATOM   4787 C  CA  . GLU B 1 320 ? 30.80189 10.50278  -72.78774  1.000 18.66928  ? 278 GLU B CA  1 
ATOM   4788 C  C   . GLU B 1 320 ? 30.58172 11.57894  -73.85666  1.000 18.08152  ? 278 GLU B C   1 
ATOM   4789 O  O   . GLU B 1 320 ? 30.02365 12.64973  -73.60103  1.000 16.36237  ? 278 GLU B O   1 
ATOM   4790 C  CB  . GLU B 1 320 ? 30.31075 10.97143  -71.41387  1.000 16.83038  ? 278 GLU B CB  1 
ATOM   4791 C  CG  . GLU B 1 320 ? 30.24724 9.83347   -70.41208  1.000 14.31383  ? 278 GLU B CG  1 
ATOM   4792 C  CD  . GLU B 1 320 ? 29.96678 10.27730  -68.99726  1.000 23.91096  ? 278 GLU B CD  1 
ATOM   4793 O  OE1 . GLU B 1 320 ? 30.06936 11.49584  -68.72000  1.000 26.78505  ? 278 GLU B OE1 1 
ATOM   4794 O  OE2 . GLU B 1 320 ? 29.60285 9.41687   -68.15818  1.000 19.50228  ? 278 GLU B OE2 1 
ATOM   4795 N  N   . CYS B 1 321 ? 30.99476 11.26253  -75.08328  1.000 17.68758  ? 279 CYS B N   1 
ATOM   4796 C  CA  . CYS B 1 321 ? 30.94981 12.25247  -76.15291  1.000 17.18474  ? 279 CYS B CA  1 
ATOM   4797 C  C   . CYS B 1 321 ? 29.52100 12.55030  -76.60158  1.000 19.77306  ? 279 CYS B C   1 
ATOM   4798 O  O   . CYS B 1 321 ? 28.73856 11.63621  -76.86810  1.000 14.93572  ? 279 CYS B O   1 
ATOM   4799 C  CB  . CYS B 1 321 ? 31.72439 11.76456  -77.35845  1.000 14.48312  ? 279 CYS B CB  1 
ATOM   4800 S  SG  . CYS B 1 321 ? 33.51335 11.85271  -77.09154  1.000 21.63141  ? 279 CYS B SG  1 
ATOM   4801 N  N   . SER B 1 322 ? 29.21731 13.83166  -76.79668  1.000 13.81001  ? 280 SER B N   1 
ATOM   4802 C  CA  . SER B 1 322 ? 27.98354 14.24387  -77.48158  1.000 17.86859  ? 280 SER B CA  1 
ATOM   4803 C  C   . SER B 1 322 ? 28.32933 14.61650  -78.91602  1.000 23.62765  ? 280 SER B C   1 
ATOM   4804 O  O   . SER B 1 322 ? 28.94025 15.66793  -79.14684  1.000 23.63401  ? 280 SER B O   1 
ATOM   4805 C  CB  . SER B 1 322 ? 27.31610 15.44010  -76.79300  1.000 22.66256  ? 280 SER B CB  1 
ATOM   4806 O  OG  . SER B 1 322 ? 26.89296 15.15793  -75.46964  1.000 16.20029  ? 280 SER B OG  1 
ATOM   4807 N  N   . CYS B 1 323 ? 27.88025 13.79834  -79.87773  1.000 20.24905  ? 281 CYS B N   1 
ATOM   4808 C  CA  . CYS B 1 323 ? 28.28224 13.89118  -81.27992  1.000 18.59329  ? 281 CYS B CA  1 
ATOM   4809 C  C   . CYS B 1 323 ? 27.08655 14.18963  -82.16773  1.000 23.25889  ? 281 CYS B C   1 
ATOM   4810 O  O   . CYS B 1 323 ? 26.02458 13.56985  -82.02236  1.000 22.04592  ? 281 CYS B O   1 
ATOM   4811 C  CB  . CYS B 1 323 ? 28.90440 12.57980  -81.77621  1.000 22.22066  ? 281 CYS B CB  1 
ATOM   4812 S  SG  . CYS B 1 323 ? 30.30989 11.96313  -80.84663  1.000 22.45386  ? 281 CYS B SG  1 
ATOM   4813 N  N   . TYR B 1 324 ? 27.26021 15.09357  -83.12470  1.000 17.71841  ? 282 TYR B N   1 
ATOM   4814 C  CA  . TYR B 1 324 ? 26.16945 15.39976  -84.03854  1.000 19.58720  ? 282 TYR B CA  1 
ATOM   4815 C  C   . TYR B 1 324 ? 26.72517 15.54542  -85.44505  1.000 21.50115  ? 282 TYR B C   1 
ATOM   4816 O  O   . TYR B 1 324 ? 27.93049 15.75273  -85.62713  1.000 22.79318  ? 282 TYR B O   1 
ATOM   4817 C  CB  . TYR B 1 324 ? 25.41960 16.67042  -83.61926  1.000 13.53802  ? 282 TYR B CB  1 
ATOM   4818 C  CG  . TYR B 1 324 ? 26.31076 17.89284  -83.60883  1.000 16.34861  ? 282 TYR B CG  1 
ATOM   4819 C  CD1 . TYR B 1 324 ? 26.47417 18.67820  -84.74449  1.000 15.13470  ? 282 TYR B CD1 1 
ATOM   4820 C  CD2 . TYR B 1 324 ? 26.98886 18.25198  -82.45704  1.000 15.44436  ? 282 TYR B CD2 1 
ATOM   4821 C  CE1 . TYR B 1 324 ? 27.31329 19.81170  -84.72577  1.000 19.06405  ? 282 TYR B CE1 1 
ATOM   4822 C  CE2 . TYR B 1 324 ? 27.82229 19.35477  -82.42784  1.000 15.20427  ? 282 TYR B CE2 1 
ATOM   4823 C  CZ  . TYR B 1 324 ? 27.98431 20.13667  -83.56409  1.000 22.63101  ? 282 TYR B CZ  1 
ATOM   4824 O  OH  . TYR B 1 324 ? 28.81407 21.26168  -83.50165  1.000 20.14668  ? 282 TYR B OH  1 
ATOM   4825 N  N   . PRO B 1 325 ? 25.87879 15.40337  -86.46158  1.000 19.23911  ? 283 PRO B N   1 
ATOM   4826 C  CA  . PRO B 1 325 ? 26.31537 15.69133  -87.83136  1.000 17.72894  ? 283 PRO B CA  1 
ATOM   4827 C  C   . PRO B 1 325 ? 26.18226 17.17878  -88.15297  1.000 25.66944  ? 283 PRO B C   1 
ATOM   4828 O  O   . PRO B 1 325 ? 25.26189 17.86021  -87.70217  1.000 26.21567  ? 283 PRO B O   1 
ATOM   4829 C  CB  . PRO B 1 325 ? 25.34387 14.84780  -88.67082  1.000 17.51562  ? 283 PRO B CB  1 
ATOM   4830 C  CG  . PRO B 1 325 ? 24.05673 14.86996  -87.84212  1.000 20.93521  ? 283 PRO B CG  1 
ATOM   4831 C  CD  . PRO B 1 325 ? 24.52510 14.79573  -86.41103  1.000 19.91627  ? 283 PRO B CD  1 
ATOM   4832 N  N   . ASP B 1 326 ? 27.12807 17.68790  -88.94840  1.000 28.96363  ? 284 ASP B N   1 
ATOM   4833 C  CA  . ASP B 1 326 ? 27.11465 19.08325  -89.40099  1.000 31.19439  ? 284 ASP B CA  1 
ATOM   4834 C  C   . ASP B 1 326 ? 27.84225 19.10778  -90.73475  1.000 29.11892  ? 284 ASP B C   1 
ATOM   4835 O  O   . ASP B 1 326 ? 29.06414 18.86689  -90.79782  1.000 27.29030  ? 284 ASP B O   1 
ATOM   4836 C  CB  . ASP B 1 326 ? 27.77406 20.04931  -88.40679  1.000 39.00422  ? 284 ASP B CB  1 
ATOM   4837 C  CG  . ASP B 1 326 ? 27.46088 21.56979  -88.71246  1.000 44.33146  ? 284 ASP B CG  1 
ATOM   4838 O  OD1 . ASP B 1 326 ? 27.81137 22.43924  -87.86907  1.000 35.36677  ? 284 ASP B OD1 1 
ATOM   4839 O  OD2 . ASP B 1 326 ? 26.84380 21.90505  -89.76190  1.000 36.40517  ? 284 ASP B OD2 1 
ATOM   4840 N  N   . ALA B 1 327 ? 27.06393 19.31403  -91.79435  1.000 25.45466  ? 285 ALA B N   1 
ATOM   4841 C  CA  . ALA B 1 327 ? 27.61627 19.52580  -93.11859  1.000 32.89161  ? 285 ALA B CA  1 
ATOM   4842 C  C   . ALA B 1 327 ? 28.39589 18.30013  -93.58931  1.000 29.41840  ? 285 ALA B C   1 
ATOM   4843 O  O   . ALA B 1 327 ? 29.47190 18.42114  -94.16661  1.000 29.89774  ? 285 ALA B O   1 
ATOM   4844 C  CB  . ALA B 1 327 ? 28.48307 20.78604  -93.13057  1.000 21.28072  ? 285 ALA B CB  1 
ATOM   4845 N  N   . GLY B 1 328 ? 27.86678 17.10412  -93.29606  1.000 28.29173  ? 286 GLY B N   1 
ATOM   4846 C  CA  . GLY B 1 328 ? 28.44051 15.85584  -93.75714  1.000 27.17995  ? 286 GLY B CA  1 
ATOM   4847 C  C   . GLY B 1 328 ? 29.61190 15.34382  -92.94550  1.000 29.20712  ? 286 GLY B C   1 
ATOM   4848 O  O   . GLY B 1 328 ? 30.12997 14.27028  -93.24830  1.000 31.40596  ? 286 GLY B O   1 
ATOM   4849 N  N   . ASP B 1 329 ? 30.04893 16.06959  -91.93896  1.000 27.11031  ? 287 ASP B N   1 
ATOM   4850 C  CA  . ASP B 1 329 ? 31.06182 15.61895  -90.99974  1.000 24.04848  ? 287 ASP B CA  1 
ATOM   4851 C  C   . ASP B 1 329 ? 30.40422 15.42813  -89.64612  1.000 25.02980  ? 287 ASP B C   1 
ATOM   4852 O  O   . ASP B 1 329 ? 29.22028 15.69944  -89.47106  1.000 23.73609  ? 287 ASP B O   1 
ATOM   4853 C  CB  . ASP B 1 329 ? 32.21282 16.62849  -90.91730  1.000 24.14424  ? 287 ASP B CB  1 
ATOM   4854 C  CG  . ASP B 1 329 ? 33.10460 16.59712  -92.15204  1.000 33.62727  ? 287 ASP B CG  1 
ATOM   4855 O  OD1 . ASP B 1 329 ? 32.88406 15.71473  -93.01344  1.000 41.20378  ? 287 ASP B OD1 1 
ATOM   4856 O  OD2 . ASP B 1 329 ? 34.02831 17.43974  -92.25960  1.000 44.67816  ? 287 ASP B OD2 1 
ATOM   4857 N  N   . ILE B 1 330 ? 31.18664 14.98938  -88.67281  1.000 18.47739  ? 288 ILE B N   1 
ATOM   4858 C  CA  . ILE B 1 330 ? 30.69607 14.72939  -87.32691  1.000 20.90979  ? 288 ILE B CA  1 
ATOM   4859 C  C   . ILE B 1 330 ? 31.50712 15.56939  -86.35801  1.000 20.82188  ? 288 ILE B C   1 
ATOM   4860 O  O   . ILE B 1 330 ? 32.72890 15.69622  -86.49454  1.000 20.73146  ? 288 ILE B O   1 
ATOM   4861 C  CB  . ILE B 1 330 ? 30.74201 13.21344  -86.97978  1.000 24.07677  ? 288 ILE B CB  1 
ATOM   4862 C  CG1 . ILE B 1 330 ? 29.86796 12.42425  -87.97191  1.000 23.85516  ? 288 ILE B CG1 1 
ATOM   4863 C  CG2 . ILE B 1 330 ? 30.27812 12.94164  -85.55357  1.000 24.92547  ? 288 ILE B CG2 1 
ATOM   4864 C  CD1 . ILE B 1 330 ? 30.59183 12.07044  -89.25583  1.000 30.65820  ? 288 ILE B CD1 1 
ATOM   4865 N  N   . MET B 1 331 ? 30.82005 16.17937  -85.40780  1.000 16.18980  ? 289 MET B N   1 
ATOM   4866 C  CA  . MET B 1 331 ? 31.45232 16.92628  -84.33990  1.000 17.60136  ? 289 MET B CA  1 
ATOM   4867 C  C   . MET B 1 331 ? 31.01719 16.30438  -83.03108  1.000 20.12502  ? 289 MET B C   1 
ATOM   4868 O  O   . MET B 1 331 ? 29.82967 16.01953  -82.83716  1.000 23.12170  ? 289 MET B O   1 
ATOM   4869 C  CB  . MET B 1 331 ? 31.06645 18.40635  -84.37638  1.000 14.86065  ? 289 MET B CB  1 
ATOM   4870 C  CG  . MET B 1 331 ? 31.55426 19.18153  -83.18467  1.000 16.87933  ? 289 MET B CG  1 
ATOM   4871 S  SD  . MET B 1 331 ? 33.36769 19.31944  -83.05056  1.000 23.49766  ? 289 MET B SD  1 
ATOM   4872 C  CE  . MET B 1 331 ? 33.82725 20.25052  -84.50764  1.000 31.11014  ? 289 MET B CE  1 
ATOM   4873 N  N   . CYS B 1 332 ? 31.97227 16.07410  -82.15694  1.000 14.85534  ? 290 CYS B N   1 
ATOM   4874 C  CA  . CYS B 1 332 ? 31.73082 15.51539  -80.84477  1.000 16.19123  ? 290 CYS B CA  1 
ATOM   4875 C  C   . CYS B 1 332 ? 32.36311 16.42703  -79.81896  1.000 19.41787  ? 290 CYS B C   1 
ATOM   4876 O  O   . CYS B 1 332 ? 33.53046 16.82581  -79.96825  1.000 21.25201  ? 290 CYS B O   1 
ATOM   4877 C  CB  . CYS B 1 332 ? 32.36236 14.13512  -80.66258  1.000 14.25967  ? 290 CYS B CB  1 
ATOM   4878 S  SG  . CYS B 1 332 ? 31.89507 12.87179  -81.78084  1.000 22.98158  ? 290 CYS B SG  1 
ATOM   4879 N  N   . VAL B 1 333 ? 31.61363 16.69139  -78.75532  1.000 16.12912  ? 291 VAL B N   1 
ATOM   4880 C  CA  . VAL B 1 333 ? 32.05134 17.50179  -77.62202  1.000 18.62013  ? 291 VAL B CA  1 
ATOM   4881 C  C   . VAL B 1 333 ? 31.90770 16.61334  -76.39693  1.000 19.41508  ? 291 VAL B C   1 
ATOM   4882 O  O   . VAL B 1 333 ? 30.83572 16.02938  -76.16402  1.000 19.92259  ? 291 VAL B O   1 
ATOM   4883 C  CB  . VAL B 1 333 ? 31.21924 18.80686  -77.49161  1.000 18.77422  ? 291 VAL B CB  1 
ATOM   4884 C  CG1 . VAL B 1 333 ? 31.57672 19.57062  -76.22619  1.000 19.98143  ? 291 VAL B CG1 1 
ATOM   4885 C  CG2 . VAL B 1 333 ? 31.44415 19.71551  -78.70702  1.000 19.34715  ? 291 VAL B CG2 1 
ATOM   4886 N  N   . CYS B 1 334 ? 32.98139 16.48579  -75.62965  1.000 13.60245  ? 292 CYS B N   1 
ATOM   4887 C  CA  . CYS B 1 334 ? 33.05052 15.36992  -74.70552  1.000 12.79219  ? 292 CYS B CA  1 
ATOM   4888 C  C   . CYS B 1 334 ? 33.40783 15.87210  -73.32628  1.000 16.51903  ? 292 CYS B C   1 
ATOM   4889 O  O   . CYS B 1 334 ? 33.33380 17.08330  -73.05243  1.000 15.38955  ? 292 CYS B O   1 
ATOM   4890 C  CB  . CYS B 1 334 ? 34.03958 14.31263  -75.22253  1.000 13.49320  ? 292 CYS B CB  1 
ATOM   4891 S  SG  . CYS B 1 334 ? 33.82995 13.94015  -77.00119  1.000 20.30947  ? 292 CYS B SG  1 
ATOM   4892 N  N   . ARG B 1 335 ? 33.78622 14.94128  -72.46248  1.000 14.22389  ? 293 ARG B N   1 
ATOM   4893 C  CA  . ARG B 1 335 ? 34.08515 15.17434  -71.05937  1.000 16.07641  ? 293 ARG B CA  1 
ATOM   4894 C  C   . ARG B 1 335 ? 35.54078 14.78916  -70.82236  1.000 21.89356  ? 293 ARG B C   1 
ATOM   4895 O  O   . ARG B 1 335 ? 35.94743 13.66048  -71.14911  1.000 15.83681  ? 293 ARG B O   1 
ATOM   4896 C  CB  . ARG B 1 335 ? 33.15807 14.32451  -70.18964  1.000 14.48092  ? 293 ARG B CB  1 
ATOM   4897 C  CG  . ARG B 1 335 ? 33.43122 14.33347  -68.70004  1.000 18.36521  ? 293 ARG B CG  1 
ATOM   4898 C  CD  . ARG B 1 335 ? 32.52302 13.29381  -68.00208  1.000 18.16254  ? 293 ARG B CD  1 
ATOM   4899 N  NE  . ARG B 1 335 ? 32.95026 13.00335  -66.64071  1.000 19.63975  ? 293 ARG B NE  1 
ATOM   4900 C  CZ  . ARG B 1 335 ? 32.18935 12.45847  -65.69600  1.000 20.41997  ? 293 ARG B CZ  1 
ATOM   4901 N  NH1 . ARG B 1 335 ? 30.92327 12.10190  -65.92857  1.000 18.24138  ? 293 ARG B NH1 1 
ATOM   4902 N  NH2 . ARG B 1 335 ? 32.68966 12.32418  -64.46640  1.000 14.28442  ? 293 ARG B NH2 1 
ATOM   4903 N  N   . ASP B 1 336 ? 36.32801 15.72710  -70.28705  1.000 18.09129  ? 294 ASP B N   1 
ATOM   4904 C  CA  . ASP B 1 336 ? 37.70117 15.45619  -69.86081  1.000 16.91197  ? 294 ASP B CA  1 
ATOM   4905 C  C   . ASP B 1 336 ? 37.64495 15.20815  -68.35815  1.000 15.83062  ? 294 ASP B C   1 
ATOM   4906 O  O   . ASP B 1 336 ? 37.48218 16.13785  -67.56399  1.000 21.46738  ? 294 ASP B O   1 
ATOM   4907 C  CB  . ASP B 1 336 ? 38.63151 16.62222  -70.22247  1.000 14.09656  ? 294 ASP B CB  1 
ATOM   4908 C  CG  . ASP B 1 336 ? 40.08302 16.44032  -69.73055  1.000 18.77013  ? 294 ASP B CG  1 
ATOM   4909 O  OD1 . ASP B 1 336 ? 40.31665 15.74233  -68.70584  1.000 21.51292  ? 294 ASP B OD1 1 
ATOM   4910 O  OD2 . ASP B 1 336 ? 41.01730 17.01197  -70.38903  1.000 21.08563  ? 294 ASP B OD2 1 
ATOM   4911 N  N   . ASN B 1 337 ? 37.80112 13.97140  -67.96701  1.000 16.18719  ? 295 ASN B N   1 
ATOM   4912 C  CA  . ASN B 1 337 ? 37.67726 13.63452  -66.56378  1.000 19.83565  ? 295 ASN B CA  1 
ATOM   4913 C  C   . ASN B 1 337 ? 39.00775 13.66442  -65.83348  1.000 21.00131  ? 295 ASN B C   1 
ATOM   4914 O  O   . ASN B 1 337 ? 39.03584 13.62220  -64.59350  1.000 22.06315  ? 295 ASN B O   1 
ATOM   4915 C  CB  . ASN B 1 337 ? 37.03883 12.24387  -66.44161  1.000 15.41370  ? 295 ASN B CB  1 
ATOM   4916 C  CG  . ASN B 1 337 ? 36.23515 12.12468  -65.20861  1.000 18.59378  ? 295 ASN B CG  1 
ATOM   4917 O  OD1 . ASN B 1 337 ? 35.22617 12.82807  -65.04433  1.000 22.02932  ? 295 ASN B OD1 1 
ATOM   4918 N  ND2 . ASN B 1 337 ? 36.68016 11.26655  -64.29493  1.000 20.91306  ? 295 ASN B ND2 1 
ATOM   4919 N  N   . TRP B 1 338 ? 40.09512 13.77661  -66.58235  1.000 17.30463  ? 296 TRP B N   1 
ATOM   4920 C  CA  . TRP B 1 338 ? 41.45888 13.71814  -66.06403  1.000 18.41389  ? 296 TRP B CA  1 
ATOM   4921 C  C   . TRP B 1 338 ? 41.92076 15.08790  -65.57098  1.000 16.02862  ? 296 TRP B C   1 
ATOM   4922 O  O   . TRP B 1 338 ? 42.24360 15.25918  -64.38873  1.000 20.47531  ? 296 TRP B O   1 
ATOM   4923 C  CB  . TRP B 1 338 ? 42.35695 13.20156  -67.18844  1.000 17.02436  ? 296 TRP B CB  1 
ATOM   4924 C  CG  . TRP B 1 338 ? 43.81768 13.16882  -66.95397  1.000 16.21489  ? 296 TRP B CG  1 
ATOM   4925 C  CD1 . TRP B 1 338 ? 44.49352 13.28766  -65.75514  1.000 13.96071  ? 296 TRP B CD1 1 
ATOM   4926 C  CD2 . TRP B 1 338 ? 44.80807 13.00890  -67.96875  1.000 21.65752  ? 296 TRP B CD2 1 
ATOM   4927 N  NE1 . TRP B 1 338 ? 45.85739 13.20386  -65.98175  1.000 16.52705  ? 296 TRP B NE1 1 
ATOM   4928 C  CE2 . TRP B 1 338 ? 46.07601 13.03201  -67.32939  1.000 21.30245  ? 296 TRP B CE2 1 
ATOM   4929 C  CE3 . TRP B 1 338 ? 44.74910 12.82628  -69.35844  1.000 17.24355  ? 296 TRP B CE3 1 
ATOM   4930 C  CZ2 . TRP B 1 338 ? 47.27551 12.88250  -68.04088  1.000 21.54524  ? 296 TRP B CZ2 1 
ATOM   4931 C  CZ3 . TRP B 1 338 ? 45.95351 12.71338  -70.07259  1.000 20.28653  ? 296 TRP B CZ3 1 
ATOM   4932 C  CH2 . TRP B 1 338 ? 47.19247 12.73095  -69.41164  1.000 20.79260  ? 296 TRP B CH2 1 
ATOM   4933 N  N   . HIS B 1 339 ? 41.92907 16.07596  -66.45744  1.000 15.62804  ? 297 HIS B N   1 
ATOM   4934 C  CA  . HIS B 1 339 ? 42.55045 17.35691  -66.10392  1.000 18.24946  ? 297 HIS B CA  1 
ATOM   4935 C  C   . HIS B 1 339 ? 42.09443 18.51599  -66.99258  1.000 20.35460  ? 297 HIS B C   1 
ATOM   4936 O  O   . HIS B 1 339 ? 42.91033 19.37560  -67.36907  1.000 19.83151  ? 297 HIS B O   1 
ATOM   4937 C  CB  . HIS B 1 339 ? 44.07605 17.18256  -66.16555  1.000 15.78864  ? 297 HIS B CB  1 
ATOM   4938 C  CG  . HIS B 1 339 ? 44.58211 16.78486  -67.51688  1.000 19.35613  ? 297 HIS B CG  1 
ATOM   4939 N  ND1 . HIS B 1 339 ? 45.87302 16.35200  -67.73372  1.000 26.22234  ? 297 HIS B ND1 1 
ATOM   4940 C  CD2 . HIS B 1 339 ? 43.97387 16.76523  -68.72641  1.000 17.08408  ? 297 HIS B CD2 1 
ATOM   4941 C  CE1 . HIS B 1 339 ? 46.04384 16.10207  -69.02049  1.000 19.38589  ? 297 HIS B CE1 1 
ATOM   4942 N  NE2 . HIS B 1 339 ? 44.90655 16.34069  -69.64566  1.000 19.28717  ? 297 HIS B NE2 1 
ATOM   4943 N  N   . GLY B 1 340 ? 40.78840 18.56812  -67.32403  1.000 22.02353  ? 298 GLY B N   1 
ATOM   4944 C  CA  . GLY B 1 340 ? 40.22204 19.62830  -68.14704  1.000 16.66072  ? 298 GLY B CA  1 
ATOM   4945 C  C   . GLY B 1 340 ? 38.88433 20.15664  -67.63866  1.000 19.61637  ? 298 GLY B C   1 
ATOM   4946 O  O   . GLY B 1 340 ? 37.93110 19.38904  -67.53187  1.000 22.15895  ? 298 GLY B O   1 
ATOM   4947 N  N   . SER B 1 341 ? 38.79774 21.45890  -67.30899  1.000 20.61648  ? 299 SER B N   1 
ATOM   4948 C  CA  . SER B 1 341 ? 37.52941 22.09801  -66.96003  1.000 17.76908  ? 299 SER B CA  1 
ATOM   4949 C  C   . SER B 1 341 ? 36.83359 22.73021  -68.16779  1.000 17.04710  ? 299 SER B C   1 
ATOM   4950 O  O   . SER B 1 341 ? 35.67473 23.16841  -68.05470  1.000 18.03425  ? 299 SER B O   1 
ATOM   4951 C  CB  . SER B 1 341 ? 37.74526 23.10710  -65.83046  1.000 16.45822  ? 299 SER B CB  1 
ATOM   4952 O  OG  . SER B 1 341 ? 38.89393 23.91480  -66.10816  1.000 21.92141  ? 299 SER B OG  1 
ATOM   4953 N  N   . ASN B 1 342 ? 37.50277 22.79225  -69.32155  1.000 15.59133  ? 300 ASN B N   1 
ATOM   4954 C  CA  . ASN B 1 342 ? 36.85268 23.05040  -70.59823  1.000 16.94622  ? 300 ASN B CA  1 
ATOM   4955 C  C   . ASN B 1 342 ? 36.64367 21.71313  -71.30050  1.000 21.32300  ? 300 ASN B C   1 
ATOM   4956 O  O   . ASN B 1 342 ? 37.12912 20.67616  -70.83624  1.000 17.46348  ? 300 ASN B O   1 
ATOM   4957 C  CB  . ASN B 1 342 ? 37.67908 24.02775  -71.45307  1.000 12.83668  ? 300 ASN B CB  1 
ATOM   4958 C  CG  . ASN B 1 342 ? 39.12599 23.56139  -71.67041  1.000 21.03970  ? 300 ASN B CG  1 
ATOM   4959 O  OD1 . ASN B 1 342 ? 39.65272 22.76353  -70.89477  1.000 22.58278  ? 300 ASN B OD1 1 
ATOM   4960 N  ND2 . ASN B 1 342 ? 39.75823 24.05348  -72.73293  1.000 17.40142  ? 300 ASN B ND2 1 
ATOM   4961 N  N   . ARG B 1 343 ? 35.86331 21.72832  -72.41328  1.000 20.35481  ? 301 ARG B N   1 
ATOM   4962 C  CA  . ARG B 1 343 ? 35.54595 20.41278  -72.98934  1.000 16.88747  ? 301 ARG B CA  1 
ATOM   4963 C  C   . ARG B 1 343 ? 36.43175 20.08438  -74.19335  1.000 20.83029  ? 301 ARG B C   1 
ATOM   4964 O  O   . ARG B 1 343 ? 36.69144 20.96484  -75.04915  1.000 16.42202  ? 301 ARG B O   1 
ATOM   4965 C  CB  . ARG B 1 343 ? 34.07113 20.32578  -73.42528  1.000 9.94774   ? 301 ARG B CB  1 
ATOM   4966 C  CG  . ARG B 1 343 ? 33.12127 20.42054  -72.25962  1.000 14.04122  ? 301 ARG B CG  1 
ATOM   4967 C  CD  . ARG B 1 343 ? 31.69474 19.97472  -72.65589  1.000 17.51208  ? 301 ARG B CD  1 
ATOM   4968 N  NE  . ARG B 1 343 ? 30.84461 19.94211  -71.47314  1.000 16.34291  ? 301 ARG B NE  1 
ATOM   4969 C  CZ  . ARG B 1 343 ? 30.81820 18.97585  -70.56390  1.000 17.52600  ? 301 ARG B CZ  1 
ATOM   4970 N  NH1 . ARG B 1 343 ? 31.50710 17.85477  -70.71980  1.000 16.81912  ? 301 ARG B NH1 1 
ATOM   4971 N  NH2 . ARG B 1 343 ? 30.07693 19.13611  -69.46999  1.000 18.14681  ? 301 ARG B NH2 1 
ATOM   4972 N  N   . PRO B 1 344 ? 36.83694 18.81159  -74.29918  1.000 17.65932  ? 302 PRO B N   1 
ATOM   4973 C  CA  . PRO B 1 344 ? 37.53548 18.35489  -75.49426  1.000 16.65774  ? 302 PRO B CA  1 
ATOM   4974 C  C   . PRO B 1 344 ? 36.56081 18.15883  -76.62836  1.000 13.86793  ? 302 PRO B C   1 
ATOM   4975 O  O   . PRO B 1 344 ? 35.38871 17.85146  -76.41596  1.000 21.54793  ? 302 PRO B O   1 
ATOM   4976 C  CB  . PRO B 1 344 ? 38.14706 17.01492  -75.04802  1.000 17.77858  ? 302 PRO B CB  1 
ATOM   4977 C  CG  . PRO B 1 344 ? 37.15644 16.50063  -74.08890  1.000 17.24320  ? 302 PRO B CG  1 
ATOM   4978 C  CD  . PRO B 1 344 ? 36.63209 17.71348  -73.34135  1.000 17.93216  ? 302 PRO B CD  1 
ATOM   4979 N  N   . TRP B 1 345 ? 37.05714 18.31562  -77.85387  1.000 15.32784  ? 303 TRP B N   1 
ATOM   4980 C  CA  . TRP B 1 345 ? 36.27419 17.95352  -79.02476  1.000 21.33384  ? 303 TRP B CA  1 
ATOM   4981 C  C   . TRP B 1 345 ? 37.11690 17.12879  -80.00134  1.000 22.75497  ? 303 TRP B C   1 
ATOM   4982 O  O   . TRP B 1 345 ? 38.35522 17.13776  -79.97169  1.000 17.58146  ? 303 TRP B O   1 
ATOM   4983 C  CB  . TRP B 1 345 ? 35.66726 19.19132  -79.72795  1.000 23.61884  ? 303 TRP B CB  1 
ATOM   4984 C  CG  . TRP B 1 345 ? 36.65504 20.21366  -80.16956  1.000 18.92187  ? 303 TRP B CG  1 
ATOM   4985 C  CD1 . TRP B 1 345 ? 37.03860 21.34531  -79.48181  1.000 22.57659  ? 303 TRP B CD1 1 
ATOM   4986 C  CD2 . TRP B 1 345 ? 37.39188 20.22053  -81.39039  1.000 23.12364  ? 303 TRP B CD2 1 
ATOM   4987 N  NE1 . TRP B 1 345 ? 37.96757 22.05353  -80.21303  1.000 18.78175  ? 303 TRP B NE1 1 
ATOM   4988 C  CE2 . TRP B 1 345 ? 38.20013 21.39249  -81.38872  1.000 23.55607  ? 303 TRP B CE2 1 
ATOM   4989 C  CE3 . TRP B 1 345 ? 37.45555 19.35906  -82.48854  1.000 22.65619  ? 303 TRP B CE3 1 
ATOM   4990 C  CZ2 . TRP B 1 345 ? 39.06659 21.70112  -82.43199  1.000 25.78816  ? 303 TRP B CZ2 1 
ATOM   4991 C  CZ3 . TRP B 1 345 ? 38.31549 19.67309  -83.52991  1.000 23.28473  ? 303 TRP B CZ3 1 
ATOM   4992 C  CH2 . TRP B 1 345 ? 39.11242 20.83665  -83.49077  1.000 24.34759  ? 303 TRP B CH2 1 
ATOM   4993 N  N   . VAL B 1 346 ? 36.40457 16.36706  -80.83465  1.000 17.96634  ? 304 VAL B N   1 
ATOM   4994 C  CA  . VAL B 1 346 ? 36.96956 15.61144  -81.95047  1.000 23.38042  ? 304 VAL B CA  1 
ATOM   4995 C  C   . VAL B 1 346 ? 35.96492 15.72024  -83.08175  1.000 22.80998  ? 304 VAL B C   1 
ATOM   4996 O  O   . VAL B 1 346 ? 34.76012 15.52525  -82.86540  1.000 23.80440  ? 304 VAL B O   1 
ATOM   4997 C  CB  . VAL B 1 346 ? 37.29033 14.11939  -81.61168  1.000 24.11973  ? 304 VAL B CB  1 
ATOM   4998 C  CG1 . VAL B 1 346 ? 36.09151 13.32464  -81.07436  1.000 16.37725  ? 304 VAL B CG1 1 
ATOM   4999 C  CG2 . VAL B 1 346 ? 37.83004 13.38180  -82.82479  1.000 19.68578  ? 304 VAL B CG2 1 
ATOM   5000 N  N   . SER B 1 347 ? 36.45475 16.05563  -84.27502  1.000 18.16951  ? 305 SER B N   1 
ATOM   5001 C  CA  . SER B 1 347 ? 35.63592 16.15309  -85.47445  1.000 20.45129  ? 305 SER B CA  1 
ATOM   5002 C  C   . SER B 1 347 ? 36.24893 15.26004  -86.53323  1.000 23.15304  ? 305 SER B C   1 
ATOM   5003 O  O   . SER B 1 347 ? 37.46074 15.04671  -86.53752  1.000 29.04665  ? 305 SER B O   1 
ATOM   5004 C  CB  . SER B 1 347 ? 35.54887 17.59002  -85.99955  1.000 16.64940  ? 305 SER B CB  1 
ATOM   5005 O  OG  . SER B 1 347 ? 36.87229 18.11088  -86.19334  1.000 32.52035  ? 305 SER B OG  1 
ATOM   5006 N  N   . PHE B 1 348 ? 35.41125 14.70392  -87.40625  1.000 20.86214  ? 306 PHE B N   1 
ATOM   5007 C  CA  . PHE B 1 348 ? 35.92228 13.79136  -88.42161  1.000 20.56885  ? 306 PHE B CA  1 
ATOM   5008 C  C   . PHE B 1 348 ? 34.96314 13.72296  -89.59096  1.000 25.94372  ? 306 PHE B C   1 
ATOM   5009 O  O   . PHE B 1 348 ? 33.77547 14.05756  -89.47715  1.000 21.08052  ? 306 PHE B O   1 
ATOM   5010 C  CB  . PHE B 1 348 ? 36.18156 12.37371  -87.87745  1.000 22.38055  ? 306 PHE B CB  1 
ATOM   5011 C  CG  . PHE B 1 348 ? 35.07347 11.81983  -87.04151  1.000 22.61952  ? 306 PHE B CG  1 
ATOM   5012 C  CD1 . PHE B 1 348 ? 34.06175 11.09473  -87.62106  1.000 16.75503  ? 306 PHE B CD1 1 
ATOM   5013 C  CD2 . PHE B 1 348 ? 35.05639 12.02384  -85.66789  1.000 22.72678  ? 306 PHE B CD2 1 
ATOM   5014 C  CE1 . PHE B 1 348 ? 33.02290 10.57536  -86.84800  1.000 22.93246  ? 306 PHE B CE1 1 
ATOM   5015 C  CE2 . PHE B 1 348 ? 34.04193 11.49033  -84.89174  1.000 23.85454  ? 306 PHE B CE2 1 
ATOM   5016 C  CZ  . PHE B 1 348 ? 33.02864 10.76196  -85.48110  1.000 15.49042  ? 306 PHE B CZ  1 
ATOM   5017 N  N   . ASN B 1 349 ? 35.50405 13.29182  -90.72547  1.000 21.00948  ? 307 ASN B N   1 
ATOM   5018 C  CA  . ASN B 1 349 ? 34.69874 13.02852  -91.90401  1.000 24.94515  ? 307 ASN B CA  1 
ATOM   5019 C  C   . ASN B 1 349 ? 34.33136 11.54251  -91.96942  1.000 25.81567  ? 307 ASN B C   1 
ATOM   5020 O  O   . ASN B 1 349 ? 34.65879 10.74186  -91.08700  1.000 22.18757  ? 307 ASN B O   1 
ATOM   5021 C  CB  . ASN B 1 349 ? 35.43377 13.49559  -93.16044  1.000 28.92556  ? 307 ASN B CB  1 
ATOM   5022 C  CG  . ASN B 1 349 ? 36.80669 12.82984  -93.33917  1.000 25.11682  ? 307 ASN B CG  1 
ATOM   5023 O  OD1 . ASN B 1 349 ? 37.08135 11.77843  -92.77900  1.000 26.81925  ? 307 ASN B OD1 1 
ATOM   5024 N  ND2 . ASN B 1 349 ? 37.68608 13.48281  -94.09562  1.000 22.24974  ? 307 ASN B ND2 1 
ATOM   5025 N  N   . GLN B 1 350 ? 33.62793 11.17242  -93.03970  1.000 31.66830  ? 308 GLN B N   1 
ATOM   5026 C  CA  . GLN B 1 350 ? 33.16872 9.79845   -93.19091  1.000 27.00971  ? 308 GLN B CA  1 
ATOM   5027 C  C   . GLN B 1 350 ? 34.29913 8.79611   -93.33613  1.000 30.96895  ? 308 GLN B C   1 
ATOM   5028 O  O   . GLN B 1 350 ? 34.04223 7.59834   -93.18697  1.000 27.98576  ? 308 GLN B O   1 
ATOM   5029 C  CB  . GLN B 1 350 ? 32.20192 9.70144   -94.37758  1.000 23.93255  ? 308 GLN B CB  1 
ATOM   5030 C  CG  . GLN B 1 350 ? 30.90774 10.46585  -94.00910  1.000 46.93554  ? 308 GLN B CG  1 
ATOM   5031 C  CD  . GLN B 1 350 ? 29.87181 10.59663  -95.10826  1.000 48.60217  ? 308 GLN B CD  1 
ATOM   5032 O  OE1 . GLN B 1 350 ? 29.23726 9.60111   -95.52915  1.000 41.63898  ? 308 GLN B OE1 1 
ATOM   5033 N  NE2 . GLN B 1 350 ? 29.64042 11.84366  -95.53894  1.000 33.31108  ? 308 GLN B NE2 1 
ATOM   5034 N  N   . ASN B 1 351 ? 35.52867 9.24256   -93.60713  1.000 28.02238  ? 309 ASN B N   1 
ATOM   5035 C  CA  . ASN B 1 351 ? 36.67207 8.35095   -93.68465  1.000 23.75514  ? 309 ASN B CA  1 
ATOM   5036 C  C   . ASN B 1 351 ? 37.42093 8.28774   -92.36939  1.000 27.75587  ? 309 ASN B C   1 
ATOM   5037 O  O   . ASN B 1 351 ? 38.49228 7.66734   -92.29625  1.000 25.41944  ? 309 ASN B O   1 
ATOM   5038 C  CB  . ASN B 1 351 ? 37.62626 8.78635   -94.80350  1.000 32.12865  ? 309 ASN B CB  1 
ATOM   5039 C  CG  . ASN B 1 351 ? 38.60000 7.67130   -95.19409  1.000 48.20356  ? 309 ASN B CG  1 
ATOM   5040 O  OD1 . ASN B 1 351 ? 38.19008 6.51867   -95.35251  1.000 41.36556  ? 309 ASN B OD1 1 
ATOM   5041 N  ND2 . ASN B 1 351 ? 39.89991 7.99924   -95.30388  1.000 44.38761  ? 309 ASN B ND2 1 
ATOM   5042 N  N   . LEU B 1 352 ? 36.87763 8.91196   -91.32682  1.000 22.79306  ? 310 LEU B N   1 
ATOM   5043 C  CA  . LEU B 1 352 ? 37.47154 8.90826   -89.99475  1.000 20.92281  ? 310 LEU B CA  1 
ATOM   5044 C  C   . LEU B 1 352 ? 38.81244 9.63045   -89.95352  1.000 29.21436  ? 310 LEU B C   1 
ATOM   5045 O  O   . LEU B 1 352 ? 39.64673 9.34747   -89.08722  1.000 24.68296  ? 310 LEU B O   1 
ATOM   5046 C  CB  . LEU B 1 352 ? 37.62813 7.48726   -89.45516  1.000 21.45960  ? 310 LEU B CB  1 
ATOM   5047 C  CG  . LEU B 1 352 ? 36.33111 6.67266   -89.36194  1.000 24.61339  ? 310 LEU B CG  1 
ATOM   5048 C  CD1 . LEU B 1 352 ? 36.60274 5.35024   -88.58264  1.000 20.14460  ? 310 LEU B CD1 1 
ATOM   5049 C  CD2 . LEU B 1 352 ? 35.18954 7.46092   -88.73360  1.000 14.35381  ? 310 LEU B CD2 1 
ATOM   5050 N  N   . GLU B 1 353 ? 39.05691 10.54375  -90.88495  1.000 27.56851  ? 311 GLU B N   1 
ATOM   5051 C  CA  . GLU B 1 353 ? 40.13894 11.50809  -90.71524  1.000 26.08980  ? 311 GLU B CA  1 
ATOM   5052 C  C   . GLU B 1 353 ? 39.66945 12.54490  -89.70875  1.000 25.54496  ? 311 GLU B C   1 
ATOM   5053 O  O   . GLU B 1 353 ? 38.61326 13.15755  -89.89818  1.000 27.39629  ? 311 GLU B O   1 
ATOM   5054 C  CB  . GLU B 1 353 ? 40.49906 12.16388  -92.04053  1.000 22.94923  ? 311 GLU B CB  1 
ATOM   5055 C  CG  . GLU B 1 353 ? 41.10495 11.20490  -93.03886  1.000 32.72535  ? 311 GLU B CG  1 
ATOM   5056 C  CD  . GLU B 1 353 ? 40.71712 11.53009  -94.46832  1.000 42.73447  ? 311 GLU B CD  1 
ATOM   5057 O  OE1 . GLU B 1 353 ? 40.28465 12.66577  -94.71987  1.000 47.90162  ? 311 GLU B OE1 1 
ATOM   5058 O  OE2 . GLU B 1 353 ? 40.89202 10.66755  -95.35111  1.000 51.17284  ? 311 GLU B OE2 1 
ATOM   5059 N  N   . TYR B 1 354 ? 40.42764 12.73587  -88.63717  1.000 21.95556  ? 312 TYR B N   1 
ATOM   5060 C  CA  . TYR B 1 354 ? 39.92185 13.47977  -87.49544  1.000 27.17784  ? 312 TYR B CA  1 
ATOM   5061 C  C   . TYR B 1 354 ? 40.81975 14.66014  -87.13241  1.000 32.89116  ? 312 TYR B C   1 
ATOM   5062 O  O   . TYR B 1 354 ? 42.00480 14.71851  -87.47913  1.000 28.87597  ? 312 TYR B O   1 
ATOM   5063 C  CB  . TYR B 1 354 ? 39.76487 12.55612  -86.28404  1.000 22.56411  ? 312 TYR B CB  1 
ATOM   5064 C  CG  . TYR B 1 354 ? 41.09203 11.95856  -85.81389  1.000 24.36484  ? 312 TYR B CG  1 
ATOM   5065 C  CD1 . TYR B 1 354 ? 41.60484 10.78625  -86.37544  1.000 27.30018  ? 312 TYR B CD1 1 
ATOM   5066 C  CD2 . TYR B 1 354 ? 41.80387 12.55677  -84.78447  1.000 26.30048  ? 312 TYR B CD2 1 
ATOM   5067 C  CE1 . TYR B 1 354 ? 42.82104 10.24230  -85.92935  1.000 26.37127  ? 312 TYR B CE1 1 
ATOM   5068 C  CE2 . TYR B 1 354 ? 42.98828 12.03081  -84.33379  1.000 25.67990  ? 312 TYR B CE2 1 
ATOM   5069 C  CZ  . TYR B 1 354 ? 43.50367 10.88085  -84.90618  1.000 26.78713  ? 312 TYR B CZ  1 
ATOM   5070 O  OH  . TYR B 1 354 ? 44.71009 10.41087  -84.41757  1.000 21.84754  ? 312 TYR B OH  1 
ATOM   5071 N  N   . GLN B 1 355 ? 40.22664 15.61033  -86.41567  1.000 23.63854  ? 313 GLN B N   1 
ATOM   5072 C  CA  . GLN B 1 355 ? 40.94820 16.69442  -85.78472  1.000 20.85683  ? 313 GLN B CA  1 
ATOM   5073 C  C   . GLN B 1 355 ? 40.49942 16.74033  -84.34341  1.000 20.33556  ? 313 GLN B C   1 
ATOM   5074 O  O   . GLN B 1 355 ? 39.40758 16.29213  -84.00632  1.000 21.90327  ? 313 GLN B O   1 
ATOM   5075 C  CB  . GLN B 1 355 ? 40.67865 18.04133  -86.45403  1.000 23.45424  ? 313 GLN B CB  1 
ATOM   5076 C  CG  . GLN B 1 355 ? 40.84938 18.03499  -87.95665  1.000 27.14634  ? 313 GLN B CG  1 
ATOM   5077 C  CD  . GLN B 1 355 ? 40.51857 19.40162  -88.57170  1.000 45.72069  ? 313 GLN B CD  1 
ATOM   5078 O  OE1 . GLN B 1 355 ? 39.40108 19.63108  -89.04286  1.000 41.12147  ? 313 GLN B OE1 1 
ATOM   5079 N  NE2 . GLN B 1 355 ? 41.50091 20.31127  -88.57269  1.000 52.17017  ? 313 GLN B NE2 1 
ATOM   5080 N  N   . ILE B 1 356 ? 41.34008 17.29760  -83.48965  1.000 15.39620  ? 314 ILE B N   1 
ATOM   5081 C  CA  . ILE B 1 356 ? 41.07097 17.34806  -82.06195  1.000 15.45436  ? 314 ILE B CA  1 
ATOM   5082 C  C   . ILE B 1 356 ? 41.39265 18.73781  -81.52763  1.000 27.94626  ? 314 ILE B C   1 
ATOM   5083 O  O   . ILE B 1 356 ? 42.15972 19.49526  -82.12487  1.000 25.48162  ? 314 ILE B O   1 
ATOM   5084 C  CB  . ILE B 1 356 ? 41.89053 16.29284  -81.29960  1.000 18.59098  ? 314 ILE B CB  1 
ATOM   5085 C  CG1 . ILE B 1 356 ? 43.38105 16.41556  -81.68491  1.000 21.56973  ? 314 ILE B CG1 1 
ATOM   5086 C  CG2 . ILE B 1 356 ? 41.30821 14.90413  -81.53064  1.000 18.94353  ? 314 ILE B CG2 1 
ATOM   5087 C  CD1 . ILE B 1 356 ? 44.31175 15.53391  -80.86178  1.000 20.74156  ? 314 ILE B CD1 1 
ATOM   5088 N  N   . GLY B 1 357 ? 40.83059 19.03903  -80.36128  1.000 21.31928  ? 315 GLY B N   1 
ATOM   5089 C  CA  . GLY B 1 357 ? 41.11597 20.28172  -79.68482  1.000 17.98386  ? 315 GLY B CA  1 
ATOM   5090 C  C   . GLY B 1 357 ? 40.31900 20.34820  -78.40891  1.000 25.00579  ? 315 GLY B C   1 
ATOM   5091 O  O   . GLY B 1 357 ? 39.68850 19.36798  -77.99858  1.000 20.92528  ? 315 GLY B O   1 
ATOM   5092 N  N   . TYR B 1 358 ? 40.39029 21.50798  -77.76466  1.000 17.62958  ? 316 TYR B N   1 
ATOM   5093 C  CA  . TYR B 1 358 ? 39.52724 21.86717  -76.65532  1.000 18.57623  ? 316 TYR B CA  1 
ATOM   5094 C  C   . TYR B 1 358 ? 38.80072 23.15864  -76.99086  1.000 20.93861  ? 316 TYR B C   1 
ATOM   5095 O  O   . TYR B 1 358 ? 39.28074 23.97034  -77.79560  1.000 23.75075  ? 316 TYR B O   1 
ATOM   5096 C  CB  . TYR B 1 358 ? 40.28655 22.05786  -75.36014  1.000 18.00465  ? 316 TYR B CB  1 
ATOM   5097 C  CG  . TYR B 1 358 ? 40.59676 20.79439  -74.65748  1.000 21.13964  ? 316 TYR B CG  1 
ATOM   5098 C  CD1 . TYR B 1 358 ? 41.58002 19.92400  -75.14895  1.000 25.72279  ? 316 TYR B CD1 1 
ATOM   5099 C  CD2 . TYR B 1 358 ? 39.92028 20.44445  -73.48863  1.000 20.41769  ? 316 TYR B CD2 1 
ATOM   5100 C  CE1 . TYR B 1 358 ? 41.88491 18.72660  -74.50048  1.000 20.10371  ? 316 TYR B CE1 1 
ATOM   5101 C  CE2 . TYR B 1 358 ? 40.22216 19.26909  -72.83297  1.000 20.74862  ? 316 TYR B CE2 1 
ATOM   5102 C  CZ  . TYR B 1 358 ? 41.21443 18.40977  -73.34431  1.000 20.56657  ? 316 TYR B CZ  1 
ATOM   5103 O  OH  . TYR B 1 358 ? 41.49748 17.22847  -72.68844  1.000 17.84745  ? 316 TYR B OH  1 
ATOM   5104 N  N   . ILE B 1 359 ? 37.62036 23.33339  -76.39833  1.000 15.94647  ? 317 ILE B N   1 
ATOM   5105 C  CA  . ILE B 1 359 ? 36.88005 24.57781  -76.60482  1.000 17.18135  ? 317 ILE B CA  1 
ATOM   5106 C  C   . ILE B 1 359 ? 37.65599 25.70837  -75.92177  1.000 19.39484  ? 317 ILE B C   1 
ATOM   5107 O  O   . ILE B 1 359 ? 37.93985 25.65297  -74.72004  1.000 19.45228  ? 317 ILE B O   1 
ATOM   5108 C  CB  . ILE B 1 359 ? 35.44356 24.46819  -76.07120  1.000 22.29503  ? 317 ILE B CB  1 
ATOM   5109 C  CG1 . ILE B 1 359 ? 34.62563 23.44693  -76.88452  1.000 16.07507  ? 317 ILE B CG1 1 
ATOM   5110 C  CG2 . ILE B 1 359 ? 34.74997 25.87352  -76.03974  1.000 19.92961  ? 317 ILE B CG2 1 
ATOM   5111 C  CD1 . ILE B 1 359 ? 33.29091 23.12082  -76.26268  1.000 20.59162  ? 317 ILE B CD1 1 
ATOM   5112 N  N   . CYS B 1 360 ? 38.01326 26.73957  -76.68429  1.000 21.29469  ? 318 CYS B N   1 
ATOM   5113 C  CA  . CYS B 1 360 ? 38.93010 27.77166  -76.17149  1.000 18.89999  ? 318 CYS B CA  1 
ATOM   5114 C  C   . CYS B 1 360 ? 38.26079 28.75851  -75.22953  1.000 24.29506  ? 318 CYS B C   1 
ATOM   5115 O  O   . CYS B 1 360 ? 38.95767 29.35981  -74.40464  1.000 24.41836  ? 318 CYS B O   1 
ATOM   5116 C  CB  . CYS B 1 360 ? 39.50941 28.56095  -77.33336  1.000 21.98152  ? 318 CYS B CB  1 
ATOM   5117 S  SG  . CYS B 1 360 ? 40.39639 27.48352  -78.48361  1.000 28.23197  ? 318 CYS B SG  1 
ATOM   5118 N  N   . SER B 1 361 ? 36.93041 28.93722  -75.33698  1.000 17.49030  ? 319 SER B N   1 
ATOM   5119 C  CA  . SER B 1 361 ? 36.24191 29.98263  -74.59580  1.000 17.50759  ? 319 SER B CA  1 
ATOM   5120 C  C   . SER B 1 361 ? 36.60736 29.95290  -73.12103  1.000 18.81490  ? 319 SER B C   1 
ATOM   5121 O  O   . SER B 1 361 ? 36.74424 28.88426  -72.51642  1.000 14.95268  ? 319 SER B O   1 
ATOM   5122 C  CB  . SER B 1 361 ? 34.72125 29.82861  -74.73557  1.000 25.29374  ? 319 SER B CB  1 
ATOM   5123 O  OG  . SER B 1 361 ? 34.09348 30.70535  -73.81818  1.000 20.67494  ? 319 SER B OG  1 
ATOM   5124 N  N   . GLY B 1 362 ? 36.76213 31.13789  -72.53958  1.000 17.19284  ? 320 GLY B N   1 
ATOM   5125 C  CA  . GLY B 1 362 ? 36.86719 31.22060  -71.08759  1.000 17.13403  ? 320 GLY B CA  1 
ATOM   5126 C  C   . GLY B 1 362 ? 35.55557 30.99729  -70.34722  1.000 24.02964  ? 320 GLY B C   1 
ATOM   5127 O  O   . GLY B 1 362 ? 35.52419 31.09347  -69.11432  1.000 18.71342  ? 320 GLY B O   1 
ATOM   5128 N  N   . ILE B 1 363 ? 34.47345 30.72455  -71.07915  1.000 17.44886  ? 321 ILE B N   1 
ATOM   5129 C  CA  . ILE B 1 363 ? 33.19570 30.29835  -70.49443  1.000 19.77122  ? 321 ILE B CA  1 
ATOM   5130 C  C   . ILE B 1 363 ? 33.30359 28.78241  -70.35103  1.000 19.54149  ? 321 ILE B C   1 
ATOM   5131 O  O   . ILE B 1 363 ? 32.91495 28.03872  -71.24308  1.000 20.79630  ? 321 ILE B O   1 
ATOM   5132 C  CB  . ILE B 1 363 ? 32.00244 30.70606  -71.37069  1.000 21.19983  ? 321 ILE B CB  1 
ATOM   5133 C  CG1 . ILE B 1 363 ? 32.02700 32.20006  -71.70044  1.000 21.35773  ? 321 ILE B CG1 1 
ATOM   5134 C  CG2 . ILE B 1 363 ? 30.64191 30.30010  -70.72800  1.000 18.22031  ? 321 ILE B CG2 1 
ATOM   5135 C  CD1 . ILE B 1 363 ? 31.85159 33.06464  -70.48337  1.000 24.86907  ? 321 ILE B CD1 1 
ATOM   5136 N  N   . PHE B 1 364 ? 33.86549 28.31814  -69.23275  1.000 12.47075  ? 322 PHE B N   1 
ATOM   5137 C  CA  . PHE B 1 364 ? 34.19675 26.90369  -69.08658  1.000 18.61304  ? 322 PHE B CA  1 
ATOM   5138 C  C   . PHE B 1 364 ? 32.93803 26.04787  -69.00352  1.000 17.79682  ? 322 PHE B C   1 
ATOM   5139 O  O   . PHE B 1 364 ? 31.99418 26.39529  -68.28837  1.000 20.36361  ? 322 PHE B O   1 
ATOM   5140 C  CB  . PHE B 1 364 ? 35.03377 26.68573  -67.83950  1.000 13.67613  ? 322 PHE B CB  1 
ATOM   5141 C  CG  . PHE B 1 364 ? 36.26283 27.54990  -67.79220  1.000 18.59672  ? 322 PHE B CG  1 
ATOM   5142 C  CD1 . PHE B 1 364 ? 37.22113 27.45357  -68.79350  1.000 16.41711  ? 322 PHE B CD1 1 
ATOM   5143 C  CD2 . PHE B 1 364 ? 36.45601 28.44795  -66.76131  1.000 19.13852  ? 322 PHE B CD2 1 
ATOM   5144 C  CE1 . PHE B 1 364 ? 38.36566 28.25430  -68.77402  1.000 22.52405  ? 322 PHE B CE1 1 
ATOM   5145 C  CE2 . PHE B 1 364 ? 37.61281 29.24131  -66.72535  1.000 23.13934  ? 322 PHE B CE2 1 
ATOM   5146 C  CZ  . PHE B 1 364 ? 38.55075 29.14866  -67.73861  1.000 19.76799  ? 322 PHE B CZ  1 
ATOM   5147 N  N   . GLY B 1 365 ? 32.95856 24.90351  -69.70356  1.000 16.43137  ? 323 GLY B N   1 
ATOM   5148 C  CA  . GLY B 1 365 ? 31.77526 24.09167  -69.91146  1.000 14.01448  ? 323 GLY B CA  1 
ATOM   5149 C  C   . GLY B 1 365 ? 31.58737 22.89757  -69.00944  1.000 20.10571  ? 323 GLY B C   1 
ATOM   5150 O  O   . GLY B 1 365 ? 30.49865 22.34503  -68.99976  1.000 16.82989  ? 323 GLY B O   1 
ATOM   5151 N  N   . ASP B 1 366 ? 32.62084 22.45022  -68.28367  1.000 20.15679  ? 324 ASP B N   1 
ATOM   5152 C  CA  . ASP B 1 366 ? 32.52124 21.24081  -67.47885  1.000 14.48755  ? 324 ASP B CA  1 
ATOM   5153 C  C   . ASP B 1 366 ? 32.03464 21.59330  -66.07686  1.000 17.44115  ? 324 ASP B C   1 
ATOM   5154 O  O   . ASP B 1 366 ? 31.86139 22.75990  -65.70840  1.000 18.31529  ? 324 ASP B O   1 
ATOM   5155 C  CB  . ASP B 1 366 ? 33.89028 20.53349  -67.40467  1.000 21.02165  ? 324 ASP B CB  1 
ATOM   5156 C  CG  . ASP B 1 366 ? 33.79042 19.01069  -67.21256  1.000 20.18106  ? 324 ASP B CG  1 
ATOM   5157 O  OD1 . ASP B 1 366 ? 32.68922 18.44945  -67.06333  1.000 15.42119  ? 324 ASP B OD1 1 
ATOM   5158 O  OD2 . ASP B 1 366 ? 34.85041 18.35042  -67.24348  1.000 24.51578  ? 324 ASP B OD2 1 
ATOM   5159 N  N   . ASN B 1 367 ? 31.83338 20.57821  -65.28291  1.000 14.11371  ? 325 ASN B N   1 
ATOM   5160 C  CA  . ASN B 1 367 ? 31.49844 20.71556  -63.87614  1.000 20.26176  ? 325 ASN B CA  1 
ATOM   5161 C  C   . ASN B 1 367 ? 32.17201 19.58723  -63.11321  1.000 21.21306  ? 325 ASN B C   1 
ATOM   5162 O  O   . ASN B 1 367 ? 31.88790 18.41935  -63.41787  1.000 15.02569  ? 325 ASN B O   1 
ATOM   5163 C  CB  . ASN B 1 367 ? 29.97718 20.64176  -63.68755  1.000 13.50259  ? 325 ASN B CB  1 
ATOM   5164 C  CG  . ASN B 1 367 ? 29.57245 20.88674  -62.28425  1.000 21.24253  ? 325 ASN B CG  1 
ATOM   5165 O  OD1 . ASN B 1 367 ? 29.41052 22.03868  -61.85453  1.000 20.55454  ? 325 ASN B OD1 1 
ATOM   5166 N  ND2 . ASN B 1 367 ? 29.42650 19.81739  -61.53017  1.000 17.72764  ? 325 ASN B ND2 1 
ATOM   5167 N  N   . PRO B 1 368 ? 33.02700 19.86513  -62.10620  1.000 22.15606  ? 326 PRO B N   1 
ATOM   5168 C  CA  . PRO B 1 368 ? 33.47130 21.18486  -61.61080  1.000 21.35835  ? 326 PRO B CA  1 
ATOM   5169 C  C   . PRO B 1 368 ? 34.32233 21.97603  -62.58652  1.000 18.81192  ? 326 PRO B C   1 
ATOM   5170 O  O   . PRO B 1 368 ? 34.67634 21.52167  -63.66825  1.000 14.29175  ? 326 PRO B O   1 
ATOM   5171 C  CB  . PRO B 1 368 ? 34.28468 20.84128  -60.35958  1.000 19.05758  ? 326 PRO B CB  1 
ATOM   5172 C  CG  . PRO B 1 368 ? 34.78945 19.43892  -60.61220  1.000 21.22129  ? 326 PRO B CG  1 
ATOM   5173 C  CD  . PRO B 1 368 ? 33.67801 18.75711  -61.37494  1.000 16.59698  ? 326 PRO B CD  1 
ATOM   5174 N  N   . ARG B 1 369 ? 34.59018 23.21882  -62.20961  1.000 23.85646  ? 327 ARG B N   1 
ATOM   5175 C  CA  . ARG B 1 369 ? 35.25242 24.20241  -63.05302  1.000 18.17821  ? 327 ARG B CA  1 
ATOM   5176 C  C   . ARG B 1 369 ? 35.55182 25.42836  -62.19489  1.000 15.08802  ? 327 ARG B C   1 
ATOM   5177 O  O   . ARG B 1 369 ? 35.04233 25.53645  -61.08300  1.000 17.11987  ? 327 ARG B O   1 
ATOM   5178 C  CB  . ARG B 1 369 ? 34.39347 24.57464  -64.27490  1.000 16.21318  ? 327 ARG B CB  1 
ATOM   5179 C  CG  . ARG B 1 369 ? 33.08904 25.31027  -63.98961  1.000 18.25901  ? 327 ARG B CG  1 
ATOM   5180 C  CD  . ARG B 1 369 ? 32.41835 25.80785  -65.26896  1.000 14.74812  ? 327 ARG B CD  1 
ATOM   5181 N  NE  . ARG B 1 369 ? 31.23891 26.60354  -64.92700  1.000 17.28701  ? 327 ARG B NE  1 
ATOM   5182 C  CZ  . ARG B 1 369 ? 30.01136 26.11403  -64.82515  1.000 23.33431  ? 327 ARG B CZ  1 
ATOM   5183 N  NH1 . ARG B 1 369 ? 29.73579 24.85786  -65.15870  1.000 17.78772  ? 327 ARG B NH1 1 
ATOM   5184 N  NH2 . ARG B 1 369 ? 29.04663 26.87572  -64.31346  1.000 18.28393  ? 327 ARG B NH2 1 
ATOM   5185 N  N   . PRO B 1 370 ? 36.45611 26.29306  -62.64302  1.000 22.31380  ? 328 PRO B N   1 
ATOM   5186 C  CA  . PRO B 1 370 ? 36.62177 27.60025  -61.99473  1.000 22.30174  ? 328 PRO B CA  1 
ATOM   5187 C  C   . PRO B 1 370 ? 35.57821 28.58420  -62.49793  1.000 20.30870  ? 328 PRO B C   1 
ATOM   5188 O  O   . PRO B 1 370 ? 34.83911 28.33510  -63.45967  1.000 16.43325  ? 328 PRO B O   1 
ATOM   5189 C  CB  . PRO B 1 370 ? 38.03653 28.04498  -62.40409  1.000 17.89062  ? 328 PRO B CB  1 
ATOM   5190 C  CG  . PRO B 1 370 ? 38.38132 27.18703  -63.61861  1.000 18.06259  ? 328 PRO B CG  1 
ATOM   5191 C  CD  . PRO B 1 370 ? 37.56601 25.95704  -63.56589  1.000 19.86962  ? 328 PRO B CD  1 
ATOM   5192 N  N   . ASN B 1 371 ? 35.52615 29.73265  -61.83062  1.000 23.59159  ? 329 ASN B N   1 
ATOM   5193 C  CA  . ASN B 1 371 ? 34.77678 30.84087  -62.40624  1.000 16.20054  ? 329 ASN B CA  1 
ATOM   5194 C  C   . ASN B 1 371 ? 35.38978 31.22086  -63.74118  1.000 17.11705  ? 329 ASN B C   1 
ATOM   5195 O  O   . ASN B 1 371 ? 36.57669 31.00773  -63.97788  1.000 22.74515  ? 329 ASN B O   1 
ATOM   5196 C  CB  . ASN B 1 371 ? 34.75922 32.02301  -61.44351  1.000 21.95951  ? 329 ASN B CB  1 
ATOM   5197 C  CG  . ASN B 1 371 ? 33.73801 31.83652  -60.34416  1.000 21.86324  ? 329 ASN B CG  1 
ATOM   5198 O  OD1 . ASN B 1 371 ? 32.58448 31.55675  -60.64015  1.000 32.48698  ? 329 ASN B OD1 1 
ATOM   5199 N  ND2 . ASN B 1 371 ? 34.16835 31.88925  -59.08320  1.000 17.14176  ? 329 ASN B ND2 1 
ATOM   5200 N  N   . ASP B 1 372 ? 34.56494 31.75767  -64.62848  1.000 20.85217  ? 330 ASP B N   1 
ATOM   5201 C  CA  . ASP B 1 372 ? 35.03853 32.16008  -65.94439  1.000 21.93143  ? 330 ASP B CA  1 
ATOM   5202 C  C   . ASP B 1 372 ? 36.18788 33.16569  -65.84003  1.000 33.21961  ? 330 ASP B C   1 
ATOM   5203 O  O   . ASP B 1 372 ? 36.18494 34.07621  -65.00117  1.000 29.21205  ? 330 ASP B O   1 
ATOM   5204 C  CB  . ASP B 1 372 ? 33.88218 32.74885  -66.74722  1.000 20.95793  ? 330 ASP B CB  1 
ATOM   5205 C  CG  . ASP B 1 372 ? 32.69598 31.77514  -66.85096  1.000 22.59118  ? 330 ASP B CG  1 
ATOM   5206 O  OD1 . ASP B 1 372 ? 32.91368 30.52126  -66.82062  1.000 21.58159  ? 330 ASP B OD1 1 
ATOM   5207 O  OD2 . ASP B 1 372 ? 31.55489 32.25417  -66.96625  1.000 25.24364  ? 330 ASP B OD2 1 
ATOM   5208 N  N   . LYS B 1 373 ? 37.17842 32.97672  -66.69805  1.000 32.79948  ? 331 LYS B N   1 
ATOM   5209 C  CA  . LYS B 1 373 ? 38.39920 33.77934  -66.78938  1.000 25.97641  ? 331 LYS B CA  1 
ATOM   5210 C  C   . LYS B 1 373 ? 39.03512 33.37149  -68.10755  1.000 33.08659  ? 331 LYS B C   1 
ATOM   5211 O  O   . LYS B 1 373 ? 38.42779 32.63365  -68.88878  1.000 37.09737  ? 331 LYS B O   1 
ATOM   5212 C  CB  . LYS B 1 373 ? 39.32996 33.56772  -65.58997  1.000 28.44291  ? 331 LYS B CB  1 
ATOM   5213 C  CG  . LYS B 1 373 ? 39.80818 32.11228  -65.40518  1.000 32.58588  ? 331 LYS B CG  1 
ATOM   5214 C  CD  . LYS B 1 373 ? 40.76543 31.89983  -64.21660  1.000 33.45375  ? 331 LYS B CD  1 
ATOM   5215 C  CE  . LYS B 1 373 ? 40.14252 32.29915  -62.87454  1.000 44.65008  ? 331 LYS B CE  1 
ATOM   5216 N  NZ  . LYS B 1 373 ? 39.02562 31.37550  -62.46896  1.000 29.53866  ? 331 LYS B NZ  1 
ATOM   5217 N  N   . THR B 1 374 ? 40.23498 33.85790  -68.38726  1.000 24.70641  ? 332 THR B N   1 
ATOM   5218 C  CA  . THR B 1 374 ? 40.87943 33.49516  -69.63822  1.000 21.54901  ? 332 THR B CA  1 
ATOM   5219 C  C   . THR B 1 374 ? 41.05073 31.97798  -69.73088  1.000 20.68526  ? 332 THR B C   1 
ATOM   5220 O  O   . THR B 1 374 ? 41.45615 31.31045  -68.77064  1.000 24.38780  ? 332 THR B O   1 
ATOM   5221 C  CB  . THR B 1 374 ? 42.21344 34.24093  -69.76763  1.000 22.13536  ? 332 THR B CB  1 
ATOM   5222 O  OG1 . THR B 1 374 ? 41.93260 35.66138  -69.78972  1.000 22.63528  ? 332 THR B OG1 1 
ATOM   5223 C  CG2 . THR B 1 374 ? 42.89960 33.86213  -71.05198  1.000 16.75529  ? 332 THR B CG2 1 
ATOM   5224 N  N   . GLY B 1 375 ? 40.65128 31.43347  -70.86854  1.000 14.68606  ? 333 GLY B N   1 
ATOM   5225 C  CA  . GLY B 1 375 ? 40.59390 30.00884  -71.09017  1.000 18.92492  ? 333 GLY B CA  1 
ATOM   5226 C  C   . GLY B 1 375 ? 41.79009 29.55735  -71.88080  1.000 25.38373  ? 333 GLY B C   1 
ATOM   5227 O  O   . GLY B 1 375 ? 42.80772 30.25329  -71.95794  1.000 28.85149  ? 333 GLY B O   1 
ATOM   5228 N  N   . SER B 1 376 ? 41.67076 28.37936  -72.48820  1.000 25.40086  ? 334 SER B N   1 
ATOM   5229 C  CA  . SER B 1 376 ? 42.80790 27.81214  -73.19799  1.000 24.55950  ? 334 SER B CA  1 
ATOM   5230 C  C   . SER B 1 376 ? 42.31921 26.89307  -74.29299  1.000 18.52446  ? 334 SER B C   1 
ATOM   5231 O  O   . SER B 1 376 ? 41.21629 26.34147  -74.20540  1.000 25.04554  ? 334 SER B O   1 
ATOM   5232 C  CB  . SER B 1 376 ? 43.74063 27.05515  -72.25667  1.000 26.09867  ? 334 SER B CB  1 
ATOM   5233 O  OG  . SER B 1 376 ? 44.58747 26.23125  -73.01856  1.000 29.10653  ? 334 SER B OG  1 
ATOM   5234 N  N   . CYS B 1 377 ? 43.13996 26.72118  -75.33697  1.000 25.10545  ? 335 CYS B N   1 
ATOM   5235 C  CA  . CYS B 1 377 ? 42.78364 25.77518  -76.40091  1.000 26.61639  ? 335 CYS B CA  1 
ATOM   5236 C  C   . CYS B 1 377 ? 43.29243 24.34990  -76.13087  1.000 29.43226  ? 335 CYS B C   1 
ATOM   5237 O  O   . CYS B 1 377 ? 43.14892 23.45469  -76.98070  1.000 27.34716  ? 335 CYS B O   1 
ATOM   5238 C  CB  . CYS B 1 377 ? 43.26349 26.29660  -77.74983  1.000 18.61327  ? 335 CYS B CB  1 
ATOM   5239 S  SG  . CYS B 1 377 ? 42.39418 27.92461  -78.22775  1.000 44.26384  ? 335 CYS B SG  1 
ATOM   5240 N  N   . GLY B 1 378 ? 43.86122 24.11950  -74.96153  1.000 27.43546  ? 336 GLY B N   1 
ATOM   5241 C  CA  . GLY B 1 378 ? 44.13443 22.78725  -74.50317  1.000 23.62367  ? 336 GLY B CA  1 
ATOM   5242 C  C   . GLY B 1 378 ? 43.44170 22.65474  -73.17756  1.000 26.36152  ? 336 GLY B C   1 
ATOM   5243 O  O   . GLY B 1 378 ? 42.66593 23.52853  -72.78074  1.000 25.26924  ? 336 GLY B O   1 
ATOM   5244 N  N   . PRO B 1 379 ? 43.71517 21.58209  -72.44852  1.000 24.02885  ? 337 PRO B N   1 
ATOM   5245 C  CA  . PRO B 1 379 ? 42.93786 21.32037  -71.23009  1.000 26.26479  ? 337 PRO B CA  1 
ATOM   5246 C  C   . PRO B 1 379 ? 43.24939 22.34537  -70.14099  1.000 28.47923  ? 337 PRO B C   1 
ATOM   5247 O  O   . PRO B 1 379 ? 44.40843 22.61813  -69.83674  1.000 22.98672  ? 337 PRO B O   1 
ATOM   5248 C  CB  . PRO B 1 379 ? 43.36261 19.89836  -70.83443  1.000 20.22404  ? 337 PRO B CB  1 
ATOM   5249 C  CG  . PRO B 1 379 ? 44.67876 19.65041  -71.58865  1.000 18.43429  ? 337 PRO B CG  1 
ATOM   5250 C  CD  . PRO B 1 379 ? 44.61343 20.46962  -72.82165  1.000 23.23110  ? 337 PRO B CD  1 
ATOM   5251 N  N   . VAL B 1 380 ? 42.19792 22.91844  -69.55662  1.000 17.41206  ? 338 VAL B N   1 
ATOM   5252 C  CA  . VAL B 1 380 ? 42.33358 23.85386  -68.44258  1.000 15.53983  ? 338 VAL B CA  1 
ATOM   5253 C  C   . VAL B 1 380 ? 42.39270 23.04188  -67.15706  1.000 24.26309  ? 338 VAL B C   1 
ATOM   5254 O  O   . VAL B 1 380 ? 41.39283 22.43077  -66.75592  1.000 23.97384  ? 338 VAL B O   1 
ATOM   5255 C  CB  . VAL B 1 380 ? 41.17050 24.85829  -68.40345  1.000 18.91695  ? 338 VAL B CB  1 
ATOM   5256 C  CG1 . VAL B 1 380 ? 41.24269 25.71344  -67.16443  1.000 12.46539  ? 338 VAL B CG1 1 
ATOM   5257 C  CG2 . VAL B 1 380 ? 41.15249 25.72119  -69.68209  1.000 18.81635  ? 338 VAL B CG2 1 
ATOM   5258 N  N   . SER B 1 381 ? 43.56674 23.01893  -66.50853  1.000 19.77586  ? 339 SER B N   1 
ATOM   5259 C  CA  . SER B 1 381 ? 43.78729 22.10061  -65.39242  1.000 18.83863  ? 339 SER B CA  1 
ATOM   5260 C  C   . SER B 1 381 ? 43.11983 22.55771  -64.09776  1.000 21.97370  ? 339 SER B C   1 
ATOM   5261 O  O   . SER B 1 381 ? 42.85063 21.71550  -63.23473  1.000 20.31464  ? 339 SER B O   1 
ATOM   5262 C  CB  . SER B 1 381 ? 45.29181 21.89587  -65.14067  1.000 24.64458  ? 339 SER B CB  1 
ATOM   5263 O  OG  . SER B 1 381 ? 45.84611 23.15866  -64.89956  1.000 25.30983  ? 339 SER B OG  1 
ATOM   5264 N  N   . SER B 1 382 ? 42.85875 23.85507  -63.92432  1.000 14.58633  ? 340 SER B N   1 
ATOM   5265 C  CA  . SER B 1 382 ? 42.19655 24.31397  -62.70605  1.000 21.14705  ? 340 SER B CA  1 
ATOM   5266 C  C   . SER B 1 382 ? 40.84655 23.60797  -62.55808  1.000 20.88984  ? 340 SER B C   1 
ATOM   5267 O  O   . SER B 1 382 ? 40.05433 23.61207  -63.49007  1.000 17.76025  ? 340 SER B O   1 
ATOM   5268 C  CB  . SER B 1 382 ? 41.98841 25.83372  -62.78357  1.000 24.98829  ? 340 SER B CB  1 
ATOM   5269 O  OG  . SER B 1 382 ? 41.41271 26.36030  -61.59849  1.000 25.68813  ? 340 SER B OG  1 
ATOM   5270 N  N   . ASN B 1 383 ? 40.60287 22.94958  -61.42227  1.000 22.47746  ? 341 ASN B N   1 
ATOM   5271 C  CA  . ASN B 1 383 ? 39.33701 22.22446  -61.21613  1.000 23.95451  ? 341 ASN B CA  1 
ATOM   5272 C  C   . ASN B 1 383 ? 39.07772 21.20204  -62.32095  1.000 22.85836  ? 341 ASN B C   1 
ATOM   5273 O  O   . ASN B 1 383 ? 37.92481 20.86887  -62.60804  1.000 20.20537  ? 341 ASN B O   1 
ATOM   5274 C  CB  . ASN B 1 383 ? 38.15842 23.20816  -61.11091  1.000 19.22067  ? 341 ASN B CB  1 
ATOM   5275 C  CG  . ASN B 1 383 ? 38.27582 24.11831  -59.91299  1.000 20.07763  ? 341 ASN B CG  1 
ATOM   5276 O  OD1 . ASN B 1 383 ? 38.28845 23.66318  -58.76910  1.000 21.98651  ? 341 ASN B OD1 1 
ATOM   5277 N  ND2 . ASN B 1 383 ? 38.39545 25.40266  -60.16188  1.000 22.49683  ? 341 ASN B ND2 1 
ATOM   5278 N  N   . GLY B 1 384 ? 40.15138 20.71724  -62.97380  1.000 22.67329  ? 342 GLY B N   1 
ATOM   5279 C  CA  . GLY B 1 384 ? 39.99819 19.90790  -64.16569  1.000 16.82413  ? 342 GLY B CA  1 
ATOM   5280 C  C   . GLY B 1 384 ? 39.61872 18.46495  -63.92360  1.000 20.37958  ? 342 GLY B C   1 
ATOM   5281 O  O   . GLY B 1 384 ? 39.10245 17.80747  -64.84089  1.000 18.76390  ? 342 GLY B O   1 
ATOM   5282 N  N   . ALA B 1 385 ? 39.86179 17.95361  -62.71698  1.000 19.18362  ? 343 ALA B N   1 
ATOM   5283 C  CA  . ALA B 1 385 ? 39.56656 16.56014  -62.43061  1.000 22.40421  ? 343 ALA B CA  1 
ATOM   5284 C  C   . ALA B 1 385 ? 38.06778 16.36242  -62.26023  1.000 21.90893  ? 343 ALA B C   1 
ATOM   5285 O  O   . ALA B 1 385 ? 37.34911 17.27351  -61.83227  1.000 16.94593  ? 343 ALA B O   1 
ATOM   5286 C  CB  . ALA B 1 385 ? 40.27073 16.08926  -61.15329  1.000 20.48702  ? 343 ALA B CB  1 
ATOM   5287 N  N   . ASN B 1 386 ? 37.62249 15.12176  -62.52834  1.000 17.86959  ? 344 ASN B N   1 
ATOM   5288 C  CA  . ASN B 1 386 ? 36.20618 14.76646  -62.54771  1.000 21.06663  ? 344 ASN B CA  1 
ATOM   5289 C  C   . ASN B 1 386 ? 35.47620 15.58370  -63.59920  1.000 18.49401  ? 344 ASN B C   1 
ATOM   5290 O  O   . ASN B 1 386 ? 36.11736 16.17561  -64.47539  1.000 17.76313  ? 344 ASN B O   1 
ATOM   5291 C  CB  . ASN B 1 386 ? 35.60295 14.93031  -61.15456  1.000 21.79458  ? 344 ASN B CB  1 
ATOM   5292 C  CG  . ASN B 1 386 ? 36.33818 14.08168  -60.13259  1.000 39.00269  ? 344 ASN B CG  1 
ATOM   5293 O  OD1 . ASN B 1 386 ? 36.73782 12.94409  -60.43308  1.000 39.47642  ? 344 ASN B OD1 1 
ATOM   5294 N  ND2 . ASN B 1 386 ? 36.55205 14.62702  -58.93874  1.000 46.46802  ? 344 ASN B ND2 1 
ATOM   5295 N  N   . GLY B 1 387 ? 34.15547 15.55359  -63.59077  1.000 16.36064  ? 345 GLY B N   1 
ATOM   5296 C  CA  . GLY B 1 387 ? 33.42532 16.17358  -64.67336  1.000 14.73884  ? 345 GLY B CA  1 
ATOM   5297 C  C   . GLY B 1 387 ? 31.97109 15.71633  -64.72865  1.000 16.39387  ? 345 GLY B C   1 
ATOM   5298 O  O   . GLY B 1 387 ? 31.42950 15.10635  -63.79297  1.000 15.08337  ? 345 GLY B O   1 
ATOM   5299 N  N   . VAL B 1 388 ? 31.34032 16.08172  -65.83497  1.000 15.41547  ? 346 VAL B N   1 
ATOM   5300 C  CA  . VAL B 1 388 ? 29.95916 15.71223  -66.10703  1.000 17.92534  ? 346 VAL B CA  1 
ATOM   5301 C  C   . VAL B 1 388 ? 29.82133 15.64101  -67.61427  1.000 15.65348  ? 346 VAL B C   1 
ATOM   5302 O  O   . VAL B 1 388 ? 30.49602 16.37750  -68.34035  1.000 15.36936  ? 346 VAL B O   1 
ATOM   5303 C  CB  . VAL B 1 388 ? 28.94651 16.69055  -65.44823  1.000 14.52214  ? 346 VAL B CB  1 
ATOM   5304 C  CG1 . VAL B 1 388 ? 28.97709 18.07149  -66.06012  1.000 13.21419  ? 346 VAL B CG1 1 
ATOM   5305 C  CG2 . VAL B 1 388 ? 27.45428 16.12403  -65.49656  1.000 12.87067  ? 346 VAL B CG2 1 
ATOM   5306 N  N   . LYS B 1 389 ? 29.02760 14.67448  -68.08983  1.000 16.96267  ? 347 LYS B N   1 
ATOM   5307 C  CA  . LYS B 1 389 ? 28.69142 14.63895  -69.50961  1.000 14.70326  ? 347 LYS B CA  1 
ATOM   5308 C  C   . LYS B 1 389 ? 28.01134 15.94225  -69.93191  1.000 16.41486  ? 347 LYS B C   1 
ATOM   5309 O  O   . LYS B 1 389 ? 27.06226 16.40161  -69.28735  1.000 16.33910  ? 347 LYS B O   1 
ATOM   5310 C  CB  . LYS B 1 389 ? 27.73314 13.47847  -69.82918  1.000 16.89914  ? 347 LYS B CB  1 
ATOM   5311 C  CG  . LYS B 1 389 ? 27.30079 13.52274  -71.31845  1.000 13.13141  ? 347 LYS B CG  1 
ATOM   5312 C  CD  . LYS B 1 389 ? 26.46030 12.35960  -71.75578  1.000 17.31246  ? 347 LYS B CD  1 
ATOM   5313 C  CE  . LYS B 1 389 ? 25.94545 12.55111  -73.16620  1.000 16.48262  ? 347 LYS B CE  1 
ATOM   5314 N  NZ  . LYS B 1 389 ? 26.98946 12.41670  -74.24945  1.000 16.49659  ? 347 LYS B NZ  1 
ATOM   5315 N  N   . GLY B 1 390 ? 28.43279 16.48137  -71.07603  1.000 17.31107  ? 348 GLY B N   1 
ATOM   5316 C  CA  . GLY B 1 390 ? 27.83298 17.68034  -71.61034  1.000 16.60756  ? 348 GLY B CA  1 
ATOM   5317 C  C   . GLY B 1 390 ? 27.90607 17.77282  -73.11796  1.000 17.05722  ? 348 GLY B C   1 
ATOM   5318 O  O   . GLY B 1 390 ? 28.21221 16.78155  -73.79262  1.000 15.34730  ? 348 GLY B O   1 
ATOM   5319 N  N   . PHE B 1 391 ? 27.65127 18.96292  -73.65655  1.000 12.01674  ? 349 PHE B N   1 
ATOM   5320 C  CA  . PHE B 1 391 ? 27.57353 19.13992  -75.09955  1.000 15.84056  ? 349 PHE B CA  1 
ATOM   5321 C  C   . PHE B 1 391 ? 27.87587 20.60247  -75.41920  1.000 16.01722  ? 349 PHE B C   1 
ATOM   5322 O  O   . PHE B 1 391 ? 27.89254 21.45483  -74.53540  1.000 15.57070  ? 349 PHE B O   1 
ATOM   5323 C  CB  . PHE B 1 391 ? 26.17659 18.75538  -75.63033  1.000 18.79474  ? 349 PHE B CB  1 
ATOM   5324 C  CG  . PHE B 1 391 ? 25.11308 19.77492  -75.29765  1.000 18.90200  ? 349 PHE B CG  1 
ATOM   5325 C  CD1 . PHE B 1 391 ? 24.43130 19.71951  -74.09244  1.000 17.05766  ? 349 PHE B CD1 1 
ATOM   5326 C  CD2 . PHE B 1 391 ? 24.85713 20.83226  -76.16913  1.000 14.28714  ? 349 PHE B CD2 1 
ATOM   5327 C  CE1 . PHE B 1 391 ? 23.47871 20.75127  -73.76932  1.000 16.51041  ? 349 PHE B CE1 1 
ATOM   5328 C  CE2 . PHE B 1 391 ? 23.93985 21.82125  -75.87517  1.000 16.21620  ? 349 PHE B CE2 1 
ATOM   5329 C  CZ  . PHE B 1 391 ? 23.24865 21.79549  -74.67577  1.000 14.51997  ? 349 PHE B CZ  1 
ATOM   5330 N  N   . SER B 1 392 ? 28.08428 20.88886  -76.70203  1.000 12.62101  ? 350 SER B N   1 
ATOM   5331 C  CA  . SER B 1 392 ? 28.13121 22.25974  -77.20002  1.000 16.08501  ? 350 SER B CA  1 
ATOM   5332 C  C   . SER B 1 392 ? 27.91232 22.18496  -78.70107  1.000 18.40021  ? 350 SER B C   1 
ATOM   5333 O  O   . SER B 1 392 ? 28.17376 21.15047  -79.31880  1.000 17.32232  ? 350 SER B O   1 
ATOM   5334 C  CB  . SER B 1 392 ? 29.48487 22.93987  -76.88734  1.000 19.57767  ? 350 SER B CB  1 
ATOM   5335 O  OG  . SER B 1 392 ? 29.64367 23.20294  -75.48940  1.000 19.34732  ? 350 SER B OG  1 
ATOM   5336 N  N   . PHE B 1 393 ? 27.47998 23.28858  -79.29612  1.000 17.14671  ? 351 PHE B N   1 
ATOM   5337 C  CA  . PHE B 1 393 ? 27.29966 23.36512  -80.74220  1.000 15.77891  ? 351 PHE B CA  1 
ATOM   5338 C  C   . PHE B 1 393 ? 28.20342 24.43952  -81.33634  1.000 22.57405  ? 351 PHE B C   1 
ATOM   5339 O  O   . PHE B 1 393 ? 28.15700 25.60175  -80.90766  1.000 22.41306  ? 351 PHE B O   1 
ATOM   5340 C  CB  . PHE B 1 393 ? 25.85081 23.67493  -81.09138  1.000 15.42117  ? 351 PHE B CB  1 
ATOM   5341 C  CG  . PHE B 1 393 ? 24.88498 22.53258  -80.76015  1.000 16.77329  ? 351 PHE B CG  1 
ATOM   5342 C  CD1 . PHE B 1 393 ? 24.88957 21.35027  -81.49825  1.000 15.47673  ? 351 PHE B CD1 1 
ATOM   5343 C  CD2 . PHE B 1 393 ? 23.99382 22.65939  -79.71463  1.000 15.36049  ? 351 PHE B CD2 1 
ATOM   5344 C  CE1 . PHE B 1 393 ? 23.99583 20.31466  -81.19525  1.000 19.30114  ? 351 PHE B CE1 1 
ATOM   5345 C  CE2 . PHE B 1 393 ? 23.09045 21.61935  -79.41091  1.000 19.22147  ? 351 PHE B CE2 1 
ATOM   5346 C  CZ  . PHE B 1 393 ? 23.11027 20.45261  -80.14079  1.000 14.67369  ? 351 PHE B CZ  1 
ATOM   5347 N  N   . LYS B 1 394 ? 28.97127 24.07009  -82.36039  1.000 19.47824  ? 352 LYS B N   1 
ATOM   5348 C  CA  . LYS B 1 394 ? 29.89317 24.99020  -83.02401  1.000 18.58052  ? 352 LYS B CA  1 
ATOM   5349 C  C   . LYS B 1 394 ? 29.19671 25.72014  -84.16906  1.000 19.80640  ? 352 LYS B C   1 
ATOM   5350 O  O   . LYS B 1 394 ? 28.59265 25.09024  -85.04316  1.000 26.44207  ? 352 LYS B O   1 
ATOM   5351 C  CB  . LYS B 1 394 ? 31.11545 24.22577  -83.54798  1.000 21.02220  ? 352 LYS B CB  1 
ATOM   5352 C  CG  . LYS B 1 394 ? 32.15269 25.05802  -84.30638  1.000 16.86717  ? 352 LYS B CG  1 
ATOM   5353 C  CD  . LYS B 1 394 ? 33.28865 24.15130  -84.85792  1.000 18.41278  ? 352 LYS B CD  1 
ATOM   5354 C  CE  . LYS B 1 394 ? 34.38349 24.94931  -85.59111  1.000 27.86236  ? 352 LYS B CE  1 
ATOM   5355 N  NZ  . LYS B 1 394 ? 33.77477 25.78718  -86.65783  1.000 25.83366  ? 352 LYS B NZ  1 
ATOM   5356 N  N   . TYR B 1 395 ? 29.28930 27.05563  -84.16385  1.000 20.35358  ? 353 TYR B N   1 
ATOM   5357 C  CA  . TYR B 1 395 ? 28.79349 27.90134  -85.24908  1.000 21.07980  ? 353 TYR B CA  1 
ATOM   5358 C  C   . TYR B 1 395 ? 29.92502 28.84096  -85.69691  1.000 24.33654  ? 353 TYR B C   1 
ATOM   5359 O  O   . TYR B 1 395 ? 30.13747 29.89240  -85.08811  1.000 20.76154  ? 353 TYR B O   1 
ATOM   5360 C  CB  . TYR B 1 395 ? 27.57472 28.68341  -84.78556  1.000 22.89985  ? 353 TYR B CB  1 
ATOM   5361 C  CG  . TYR B 1 395 ? 26.26949 27.92236  -84.76959  1.000 23.71770  ? 353 TYR B CG  1 
ATOM   5362 C  CD1 . TYR B 1 395 ? 25.45643 27.89993  -85.89509  1.000 19.57953  ? 353 TYR B CD1 1 
ATOM   5363 C  CD2 . TYR B 1 395 ? 25.82323 27.27782  -83.61622  1.000 19.50963  ? 353 TYR B CD2 1 
ATOM   5364 C  CE1 . TYR B 1 395 ? 24.24888 27.24830  -85.90253  1.000 24.43554  ? 353 TYR B CE1 1 
ATOM   5365 C  CE2 . TYR B 1 395 ? 24.58766 26.60067  -83.61504  1.000 20.18517  ? 353 TYR B CE2 1 
ATOM   5366 C  CZ  . TYR B 1 395 ? 23.82011 26.59112  -84.77355  1.000 24.25813  ? 353 TYR B CZ  1 
ATOM   5367 O  OH  . TYR B 1 395 ? 22.59463 25.95889  -84.81147  1.000 25.45618  ? 353 TYR B OH  1 
ATOM   5368 N  N   . GLY B 1 396 ? 30.63789 28.47663  -86.76882  1.000 16.61020  ? 354 GLY B N   1 
ATOM   5369 C  CA  . GLY B 1 396 ? 31.78795 29.25344  -87.19743  1.000 25.82959  ? 354 GLY B CA  1 
ATOM   5370 C  C   . GLY B 1 396 ? 32.81985 29.19896  -86.09885  1.000 26.65916  ? 354 GLY B C   1 
ATOM   5371 O  O   . GLY B 1 396 ? 33.15398 28.12129  -85.60086  1.000 22.97527  ? 354 GLY B O   1 
ATOM   5372 N  N   . ASN B 1 397 ? 33.27346 30.36603  -85.65416  1.000 23.21781  ? 355 ASN B N   1 
ATOM   5373 C  CA  . ASN B 1 397 ? 34.14810 30.47111  -84.48963  1.000 17.68257  ? 355 ASN B CA  1 
ATOM   5374 C  C   . ASN B 1 397 ? 33.37719 30.60216  -83.19690  1.000 20.67611  ? 355 ASN B C   1 
ATOM   5375 O  O   . ASN B 1 397 ? 33.99989 30.68719  -82.13103  1.000 18.82752  ? 355 ASN B O   1 
ATOM   5376 C  CB  . ASN B 1 397 ? 35.06559 31.69979  -84.59263  1.000 28.32191  ? 355 ASN B CB  1 
ATOM   5377 C  CG  . ASN B 1 397 ? 35.89124 31.70137  -85.83983  1.000 36.18006  ? 355 ASN B CG  1 
ATOM   5378 O  OD1 . ASN B 1 397 ? 36.46487 30.68766  -86.22306  1.000 37.37413  ? 355 ASN B OD1 1 
ATOM   5379 N  ND2 . ASN B 1 397 ? 35.94941 32.84777  -86.49523  1.000 55.89326  ? 355 ASN B ND2 1 
ATOM   5380 N  N   . GLY B 1 398 ? 32.02830 30.70622  -83.26611  1.000 21.85352  ? 356 GLY B N   1 
ATOM   5381 C  CA  . GLY B 1 398 ? 31.23980 30.84108  -82.06295  1.000 20.45991  ? 356 GLY B CA  1 
ATOM   5382 C  C   . GLY B 1 398 ? 30.79398 29.48366  -81.56608  1.000 25.01526  ? 356 GLY B C   1 
ATOM   5383 O  O   . GLY B 1 398 ? 30.95667 28.46549  -82.23590  1.000 23.42211  ? 356 GLY B O   1 
ATOM   5384 N  N   . VAL B 1 399 ? 30.23841 29.46980  -80.36065  1.000 19.88749  ? 357 VAL B N   1 
ATOM   5385 C  CA  . VAL B 1 399 ? 29.81839 28.20598  -79.77086  1.000 26.02459  ? 357 VAL B CA  1 
ATOM   5386 C  C   . VAL B 1 399 ? 28.61705 28.47375  -78.87688  1.000 21.24457  ? 357 VAL B C   1 
ATOM   5387 O  O   . VAL B 1 399 ? 28.55462 29.49954  -78.18257  1.000 19.59852  ? 357 VAL B O   1 
ATOM   5388 C  CB  . VAL B 1 399 ? 30.97350 27.52032  -78.99773  1.000 19.50803  ? 357 VAL B CB  1 
ATOM   5389 C  CG1 . VAL B 1 399 ? 31.49970 28.41432  -77.87492  1.000 18.81226  ? 357 VAL B CG1 1 
ATOM   5390 C  CG2 . VAL B 1 399 ? 30.52347 26.15617  -78.47397  1.000 21.03240  ? 357 VAL B CG2 1 
ATOM   5391 N  N   . TRP B 1 400 ? 27.63773 27.56751  -78.93795  1.000 24.16700  ? 358 TRP B N   1 
ATOM   5392 C  CA  . TRP B 1 400 ? 26.58461 27.49502  -77.93624  1.000 15.27464  ? 358 TRP B CA  1 
ATOM   5393 C  C   . TRP B 1 400 ? 26.98601 26.48257  -76.86653  1.000 20.67002  ? 358 TRP B C   1 
ATOM   5394 O  O   . TRP B 1 400 ? 27.10979 25.28508  -77.15363  1.000 14.73106  ? 358 TRP B O   1 
ATOM   5395 C  CB  . TRP B 1 400 ? 25.25397 27.10252  -78.57709  1.000 17.53104  ? 358 TRP B CB  1 
ATOM   5396 C  CG  . TRP B 1 400 ? 24.34897 28.22199  -79.12233  1.000 19.84018  ? 358 TRP B CG  1 
ATOM   5397 C  CD1 . TRP B 1 400 ? 24.08535 28.51593  -80.43868  1.000 16.30838  ? 358 TRP B CD1 1 
ATOM   5398 C  CD2 . TRP B 1 400 ? 23.53363 29.10233  -78.34952  1.000 13.60920  ? 358 TRP B CD2 1 
ATOM   5399 N  NE1 . TRP B 1 400 ? 23.16262 29.54320  -80.52505  1.000 20.58316  ? 358 TRP B NE1 1 
ATOM   5400 C  CE2 . TRP B 1 400 ? 22.82478 29.93241  -79.25519  1.000 19.79995  ? 358 TRP B CE2 1 
ATOM   5401 C  CE3 . TRP B 1 400 ? 23.36832 29.30729  -76.97960  1.000 17.86610  ? 358 TRP B CE3 1 
ATOM   5402 C  CZ2 . TRP B 1 400 ? 21.92145 30.91956  -78.82704  1.000 19.45253  ? 358 TRP B CZ2 1 
ATOM   5403 C  CZ3 . TRP B 1 400 ? 22.46611 30.30162  -76.55510  1.000 17.72677  ? 358 TRP B CZ3 1 
ATOM   5404 C  CH2 . TRP B 1 400 ? 21.74731 31.07270  -77.48216  1.000 18.39573  ? 358 TRP B CH2 1 
ATOM   5405 N  N   . ILE B 1 401 ? 27.15119 26.95532  -75.63167  1.000 19.06605  ? 359 ILE B N   1 
ATOM   5406 C  CA  . ILE B 1 401 ? 27.60796 26.14171  -74.50392  1.000 22.96430  ? 359 ILE B CA  1 
ATOM   5407 C  C   . ILE B 1 401 ? 26.42517 25.86608  -73.57904  1.000 25.24518  ? 359 ILE B C   1 
ATOM   5408 O  O   . ILE B 1 401 ? 25.81838 26.80433  -73.05798  1.000 19.61759  ? 359 ILE B O   1 
ATOM   5409 C  CB  . ILE B 1 401 ? 28.72684 26.87389  -73.74743  1.000 15.31667  ? 359 ILE B CB  1 
ATOM   5410 C  CG1 . ILE B 1 401 ? 29.96900 26.98867  -74.63306  1.000 14.08102  ? 359 ILE B CG1 1 
ATOM   5411 C  CG2 . ILE B 1 401 ? 29.04174 26.24634  -72.37305  1.000 18.90173  ? 359 ILE B CG2 1 
ATOM   5412 C  CD1 . ILE B 1 401 ? 30.99505 28.05330  -74.10166  1.000 14.25401  ? 359 ILE B CD1 1 
ATOM   5413 N  N   . GLY B 1 402 ? 26.13096 24.59716  -73.30375  1.000 25.02636  ? 360 GLY B N   1 
ATOM   5414 C  CA  . GLY B 1 402 ? 25.20919 24.26068  -72.23412  1.000 11.97581  ? 360 GLY B CA  1 
ATOM   5415 C  C   . GLY B 1 402 ? 26.03617 23.83112  -71.03935  1.000 17.45632  ? 360 GLY B C   1 
ATOM   5416 O  O   . GLY B 1 402 ? 26.95074 23.02832  -71.18086  1.000 21.88153  ? 360 GLY B O   1 
ATOM   5417 N  N   . ARG B 1 403 ? 25.70104 24.35843  -69.86151  1.000 12.00454  ? 361 ARG B N   1 
ATOM   5418 C  CA  . ARG B 1 403 ? 26.49549 24.00949  -68.69220  1.000 13.63650  ? 361 ARG B CA  1 
ATOM   5419 C  C   . ARG B 1 403 ? 25.65630 24.18134  -67.44541  1.000 12.85655  ? 361 ARG B C   1 
ATOM   5420 O  O   . ARG B 1 403 ? 24.62922 24.85841  -67.46491  1.000 18.93502  ? 361 ARG B O   1 
ATOM   5421 C  CB  . ARG B 1 403 ? 27.77371 24.87718  -68.60305  1.000 18.69885  ? 361 ARG B CB  1 
ATOM   5422 C  CG  . ARG B 1 403 ? 27.46187 26.41248  -68.41602  1.000 15.34145  ? 361 ARG B CG  1 
ATOM   5423 C  CD  . ARG B 1 403 ? 28.77925 27.22640  -68.26304  1.000 19.87945  ? 361 ARG B CD  1 
ATOM   5424 N  NE  . ARG B 1 403 ? 28.57074 28.57234  -67.72750  1.000 19.67732  ? 361 ARG B NE  1 
ATOM   5425 C  CZ  . ARG B 1 403 ? 29.55698 29.40070  -67.39877  1.000 24.92232  ? 361 ARG B CZ  1 
ATOM   5426 N  NH1 . ARG B 1 403 ? 30.83405 29.05687  -67.54403  1.000 16.77854  ? 361 ARG B NH1 1 
ATOM   5427 N  NH2 . ARG B 1 403 ? 29.26186 30.58245  -66.87345  1.000 20.82751  ? 361 ARG B NH2 1 
ATOM   5428 N  N   . THR B 1 404 ? 26.11246 23.57912  -66.34934  1.000 15.76156  ? 362 THR B N   1 
ATOM   5429 C  CA  . THR B 1 404 ? 25.50214 23.86203  -65.06075  1.000 12.27340  ? 362 THR B CA  1 
ATOM   5430 C  C   . THR B 1 404 ? 25.72422 25.33894  -64.70144  1.000 20.94574  ? 362 THR B C   1 
ATOM   5431 O  O   . THR B 1 404 ? 26.60322 26.01865  -65.25741  1.000 19.32933  ? 362 THR B O   1 
ATOM   5432 C  CB  . THR B 1 404 ? 26.10938 22.98890  -63.96803  1.000 19.38006  ? 362 THR B CB  1 
ATOM   5433 O  OG1 . THR B 1 404 ? 27.46754 23.42486  -63.70693  1.000 20.33435  ? 362 THR B OG1 1 
ATOM   5434 C  CG2 . THR B 1 404 ? 26.11048 21.44310  -64.39049  1.000 13.50910  ? 362 THR B CG2 1 
ATOM   5435 N  N   . LYS B 1 405 ? 24.91237 25.83703  -63.76172  1.000 20.91395  ? 363 LYS B N   1 
ATOM   5436 C  CA  . LYS B 1 405 ? 25.11534 27.17766  -63.22341  1.000 17.98284  ? 363 LYS B CA  1 
ATOM   5437 C  C   . LYS B 1 405 ? 26.08830 27.16258  -62.05924  1.000 19.76272  ? 363 LYS B C   1 
ATOM   5438 O  O   . LYS B 1 405 ? 26.79848 28.14390  -61.84565  1.000 18.40503  ? 363 LYS B O   1 
ATOM   5439 C  CB  . LYS B 1 405 ? 23.78422 27.80878  -62.76802  1.000 12.88707  ? 363 LYS B CB  1 
ATOM   5440 C  CG  . LYS B 1 405 ? 22.87816 28.25331  -63.91747  1.000 16.95565  ? 363 LYS B CG  1 
ATOM   5441 C  CD  . LYS B 1 405 ? 21.62025 28.90964  -63.39454  1.000 16.56744  ? 363 LYS B CD  1 
ATOM   5442 C  CE  . LYS B 1 405 ? 20.79620 29.60688  -64.50798  1.000 21.70588  ? 363 LYS B CE  1 
ATOM   5443 N  NZ  . LYS B 1 405 ? 21.61770 30.74563  -65.09613  1.000 24.46489  ? 363 LYS B NZ  1 
ATOM   5444 N  N   . SER B 1 406 ? 26.12836 26.07780  -61.29242  1.000 15.15919  ? 364 SER B N   1 
ATOM   5445 C  CA  . SER B 1 406 ? 27.09233 25.95051  -60.20385  1.000 18.66676  ? 364 SER B CA  1 
ATOM   5446 C  C   . SER B 1 406 ? 28.46048 25.55690  -60.74446  1.000 21.15905  ? 364 SER B C   1 
ATOM   5447 O  O   . SER B 1 406 ? 28.57773 24.70877  -61.64091  1.000 20.86759  ? 364 SER B O   1 
ATOM   5448 C  CB  . SER B 1 406 ? 26.63304 24.88800  -59.20667  1.000 22.17967  ? 364 SER B CB  1 
ATOM   5449 O  OG  . SER B 1 406 ? 27.67630 24.58700  -58.29860  1.000 20.59598  ? 364 SER B OG  1 
ATOM   5450 N  N   . ILE B 1 407 ? 29.50746 26.14885  -60.17473  1.000 18.39114  ? 365 ILE B N   1 
ATOM   5451 C  CA  . ILE B 1 407 ? 30.84008 25.73511  -60.59137  1.000 21.45021  ? 365 ILE B CA  1 
ATOM   5452 C  C   . ILE B 1 407 ? 31.29958 24.47825  -59.88057  1.000 23.58138  ? 365 ILE B C   1 
ATOM   5453 O  O   . ILE B 1 407 ? 32.27564 23.86356  -60.30944  1.000 20.87642  ? 365 ILE B O   1 
ATOM   5454 C  CB  . ILE B 1 407 ? 31.90501 26.81671  -60.35501  1.000 17.70056  ? 365 ILE B CB  1 
ATOM   5455 C  CG1 . ILE B 1 407 ? 32.00705 27.17874  -58.86631  1.000 23.58274  ? 365 ILE B CG1 1 
ATOM   5456 C  CG2 . ILE B 1 407 ? 31.59972 28.00480  -61.23910  1.000 18.97625  ? 365 ILE B CG2 1 
ATOM   5457 C  CD1 . ILE B 1 407 ? 33.14660 28.23222  -58.51829  1.000 17.92729  ? 365 ILE B CD1 1 
ATOM   5458 N  N   . SER B 1 408 ? 30.63577 24.07561  -58.80759  1.000 16.51255  ? 366 SER B N   1 
ATOM   5459 C  CA  . SER B 1 408 ? 31.16286 22.99342  -58.01375  1.000 16.83852  ? 366 SER B CA  1 
ATOM   5460 C  C   . SER B 1 408 ? 30.26497 21.77154  -57.96209  1.000 20.17208  ? 366 SER B C   1 
ATOM   5461 O  O   . SER B 1 408 ? 30.77897 20.67370  -57.70998  1.000 14.40881  ? 366 SER B O   1 
ATOM   5462 C  CB  . SER B 1 408 ? 31.43779 23.46305  -56.58198  1.000 18.34872  ? 366 SER B CB  1 
ATOM   5463 O  OG  . SER B 1 408 ? 30.22659 23.89048  -56.03105  1.000 21.56604  ? 366 SER B OG  1 
ATOM   5464 N  N   . SER B 1 409 ? 28.95942 21.90237  -58.21595  1.000 17.56128  ? 367 SER B N   1 
ATOM   5465 C  CA  . SER B 1 409 ? 28.08278 20.74036  -58.16403  1.000 22.98747  ? 367 SER B CA  1 
ATOM   5466 C  C   . SER B 1 409 ? 27.06848 20.77400  -59.29661  1.000 18.31092  ? 367 SER B C   1 
ATOM   5467 O  O   . SER B 1 409 ? 26.97615 21.71932  -60.07494  1.000 15.70525  ? 367 SER B O   1 
ATOM   5468 C  CB  . SER B 1 409 ? 27.35374 20.62716  -56.81965  1.000 26.83471  ? 367 SER B CB  1 
ATOM   5469 O  OG  . SER B 1 409 ? 26.64128 21.80160  -56.57417  1.000 36.99790  ? 367 SER B OG  1 
ATOM   5470 N  N   . ARG B 1 410 ? 26.33554 19.67825  -59.42454  1.000 18.13460  ? 368 ARG B N   1 
ATOM   5471 C  CA  . ARG B 1 410 ? 25.48299 19.50575  -60.58655  1.000 14.51499  ? 368 ARG B CA  1 
ATOM   5472 C  C   . ARG B 1 410 ? 24.15014 20.19064  -60.28630  1.000 15.55841  ? 368 ARG B C   1 
ATOM   5473 O  O   . ARG B 1 410 ? 23.13290 19.55593  -59.98774  1.000 20.28949  ? 368 ARG B O   1 
ATOM   5474 C  CB  . ARG B 1 410 ? 25.35017 18.01860  -60.91190  1.000 18.81073  ? 368 ARG B CB  1 
ATOM   5475 C  CG  . ARG B 1 410 ? 26.70298 17.41569  -61.34489  1.000 18.56178  ? 368 ARG B CG  1 
ATOM   5476 C  CD  . ARG B 1 410 ? 26.59923 15.86971  -61.43427  1.000 23.28623  ? 368 ARG B CD  1 
ATOM   5477 N  NE  . ARG B 1 410 ? 27.83391 15.32476  -61.98202  1.000 18.70822  ? 368 ARG B NE  1 
ATOM   5478 C  CZ  . ARG B 1 410 ? 28.04731 14.04850  -62.26650  1.000 22.77415  ? 368 ARG B CZ  1 
ATOM   5479 N  NH1 . ARG B 1 410 ? 27.11490 13.12403  -62.05884  1.000 22.73030  ? 368 ARG B NH1 1 
ATOM   5480 N  NH2 . ARG B 1 410 ? 29.22335 13.69006  -62.77220  1.000 17.54233  ? 368 ARG B NH2 1 
ATOM   5481 N  N   . ASN B 1 411 ? 24.17968 21.53143  -60.34750  1.000 16.83368  ? 369 ASN B N   1 
ATOM   5482 C  CA  . ASN B 1 411 ? 23.03052 22.38720  -60.09128  1.000 15.15529  ? 369 ASN B CA  1 
ATOM   5483 C  C   . ASN B 1 411 ? 22.88976 23.45223  -61.17152  1.000 21.21129  ? 369 ASN B C   1 
ATOM   5484 O  O   . ASN B 1 411 ? 23.87787 24.10349  -61.56869  1.000 18.68824  ? 369 ASN B O   1 
ATOM   5485 C  CB  . ASN B 1 411 ? 23.14667 23.11108  -58.73616  1.000 20.16103  ? 369 ASN B CB  1 
ATOM   5486 C  CG  . ASN B 1 411 ? 23.04335 22.17529  -57.57543  1.000 30.67159  ? 369 ASN B CG  1 
ATOM   5487 O  OD1 . ASN B 1 411 ? 24.04401 21.73849  -57.04552  1.000 31.88668  ? 369 ASN B OD1 1 
ATOM   5488 N  ND2 . ASN B 1 411 ? 21.80709 21.83353  -57.17943  1.000 30.85329  ? 369 ASN B ND2 1 
ATOM   5489 N  N   . GLY B 1 412 ? 21.64388 23.69038  -61.57056  1.000 12.20468  ? 370 GLY B N   1 
ATOM   5490 C  CA  . GLY B 1 412 ? 21.32970 24.71290  -62.54526  1.000 12.80178  ? 370 GLY B CA  1 
ATOM   5491 C  C   . GLY B 1 412 ? 21.70808 24.26613  -63.93016  1.000 15.13758  ? 370 GLY B C   1 
ATOM   5492 O  O   . GLY B 1 412 ? 22.42740 23.28619  -64.13723  1.000 13.61291  ? 370 GLY B O   1 
ATOM   5493 N  N   . PHE B 1 413 ? 21.21935 25.01808  -64.90297  1.000 12.12862  ? 371 PHE B N   1 
ATOM   5494 C  CA  . PHE B 1 413 ? 21.62148 24.81786  -66.28273  1.000 16.69423  ? 371 PHE B CA  1 
ATOM   5495 C  C   . PHE B 1 413 ? 21.32928 26.10195  -67.05884  1.000 18.23344  ? 371 PHE B C   1 
ATOM   5496 O  O   . PHE B 1 413 ? 20.31263 26.77794  -66.80743  1.000 14.47913  ? 371 PHE B O   1 
ATOM   5497 C  CB  . PHE B 1 413 ? 20.90294 23.60489  -66.91022  1.000 14.47858  ? 371 PHE B CB  1 
ATOM   5498 C  CG  . PHE B 1 413 ? 21.66048 22.98028  -68.04536  1.000 17.77054  ? 371 PHE B CG  1 
ATOM   5499 C  CD1 . PHE B 1 413 ? 22.70971 22.08463  -67.79674  1.000 14.46085  ? 371 PHE B CD1 1 
ATOM   5500 C  CD2 . PHE B 1 413 ? 21.36337 23.30460  -69.36145  1.000 16.49504  ? 371 PHE B CD2 1 
ATOM   5501 C  CE1 . PHE B 1 413 ? 23.43969 21.50855  -68.83879  1.000 14.33222  ? 371 PHE B CE1 1 
ATOM   5502 C  CE2 . PHE B 1 413 ? 22.10758 22.71361  -70.41104  1.000 19.82998  ? 371 PHE B CE2 1 
ATOM   5503 C  CZ  . PHE B 1 413 ? 23.14983 21.82225  -70.13438  1.000 15.91542  ? 371 PHE B CZ  1 
ATOM   5504 N  N   . GLU B 1 414 ? 22.22124 26.42274  -68.00003  1.000 18.25689  ? 372 GLU B N   1 
ATOM   5505 C  CA  . GLU B 1 414 ? 22.09268 27.61412  -68.83299  1.000 19.97290  ? 372 GLU B CA  1 
ATOM   5506 C  C   . GLU B 1 414 ? 22.70515 27.32978  -70.19814  1.000 20.39192  ? 372 GLU B C   1 
ATOM   5507 O  O   . GLU B 1 414 ? 23.59855 26.47784  -70.33605  1.000 20.91210  ? 372 GLU B O   1 
ATOM   5508 C  CB  . GLU B 1 414 ? 22.75542 28.81551  -68.15038  1.000 15.06404  ? 372 GLU B CB  1 
ATOM   5509 C  CG  . GLU B 1 414 ? 24.26805 28.61328  -67.87982  1.000 17.72290  ? 372 GLU B CG  1 
ATOM   5510 C  CD  . GLU B 1 414 ? 24.87406 29.65476  -66.93211  1.000 28.89083  ? 372 GLU B CD  1 
ATOM   5511 O  OE1 . GLU B 1 414 ? 26.13997 29.66375  -66.78922  1.000 25.54458  ? 372 GLU B OE1 1 
ATOM   5512 O  OE2 . GLU B 1 414 ? 24.09631 30.45166  -66.32583  1.000 20.90368  ? 372 GLU B OE2 1 
ATOM   5513 N  N   . MET B 1 415 ? 22.18260 28.01183  -71.21700  1.000 15.38007  ? 373 MET B N   1 
ATOM   5514 C  CA  . MET B 1 415 ? 22.75871 28.01949  -72.55511  1.000 13.80542  ? 373 MET B CA  1 
ATOM   5515 C  C   . MET B 1 415 ? 23.45501 29.36594  -72.78871  1.000 19.96836  ? 373 MET B C   1 
ATOM   5516 O  O   . MET B 1 415 ? 22.85821 30.42265  -72.57049  1.000 17.88449  ? 373 MET B O   1 
ATOM   5517 C  CB  . MET B 1 415 ? 21.68149 27.78799  -73.63152  1.000 14.47551  ? 373 MET B CB  1 
ATOM   5518 C  CG  . MET B 1 415 ? 21.01022 26.41039  -73.57727  1.000 21.66172  ? 373 MET B CG  1 
ATOM   5519 S  SD  . MET B 1 415 ? 22.30263 25.15197  -73.76727  1.000 21.06252  ? 373 MET B SD  1 
ATOM   5520 C  CE  . MET B 1 415 ? 22.85384 25.40234  -75.45774  1.000 16.25975  ? 373 MET B CE  1 
ATOM   5521 N  N   . ILE B 1 416 ? 24.68423 29.33542  -73.29321  1.000 19.70044  ? 374 ILE B N   1 
ATOM   5522 C  CA  . ILE B 1 416 ? 25.47113 30.55109  -73.46996  1.000 22.56658  ? 374 ILE B CA  1 
ATOM   5523 C  C   . ILE B 1 416 ? 25.94686 30.60953  -74.90393  1.000 20.49655  ? 374 ILE B C   1 
ATOM   5524 O  O   . ILE B 1 416 ? 26.56716 29.65813  -75.40551  1.000 18.66107  ? 374 ILE B O   1 
ATOM   5525 C  CB  . ILE B 1 416 ? 26.65200 30.64928  -72.48961  1.000 21.40190  ? 374 ILE B CB  1 
ATOM   5526 C  CG1 . ILE B 1 416 ? 26.11965 30.92722  -71.08525  1.000 17.30129  ? 374 ILE B CG1 1 
ATOM   5527 C  CG2 . ILE B 1 416 ? 27.53912 31.80313  -72.87875  1.000 21.83839  ? 374 ILE B CG2 1 
ATOM   5528 C  CD1 . ILE B 1 416 ? 27.17004 30.91352  -69.99600  1.000 23.32134  ? 374 ILE B CD1 1 
ATOM   5529 N  N   . TRP B 1 417 ? 25.63474 31.71722  -75.57017  1.000 16.23273  ? 375 TRP B N   1 
ATOM   5530 C  CA  . TRP B 1 417 ? 26.12261 31.94339  -76.91329  1.000 18.69056  ? 375 TRP B CA  1 
ATOM   5531 C  C   . TRP B 1 417 ? 27.40402 32.77740  -76.80046  1.000 19.36509  ? 375 TRP B C   1 
ATOM   5532 O  O   . TRP B 1 417 ? 27.37571 33.91938  -76.32865  1.000 18.74679  ? 375 TRP B O   1 
ATOM   5533 C  CB  . TRP B 1 417 ? 25.06185 32.63040  -77.76392  1.000 16.59804  ? 375 TRP B CB  1 
ATOM   5534 C  CG  . TRP B 1 417 ? 25.62184 33.14237  -79.06653  1.000 23.47633  ? 375 TRP B CG  1 
ATOM   5535 C  CD1 . TRP B 1 417 ? 25.68522 34.44771  -79.47430  1.000 23.08437  ? 375 TRP B CD1 1 
ATOM   5536 C  CD2 . TRP B 1 417 ? 26.21659 32.36218  -80.12120  1.000 22.83230  ? 375 TRP B CD2 1 
ATOM   5537 N  NE1 . TRP B 1 417 ? 26.25144 34.52538  -80.72881  1.000 25.81157  ? 375 TRP B NE1 1 
ATOM   5538 C  CE2 . TRP B 1 417 ? 26.59525 33.26272  -81.14455  1.000 21.34830  ? 375 TRP B CE2 1 
ATOM   5539 C  CE3 . TRP B 1 417 ? 26.43723 30.98739  -80.31372  1.000 24.28952  ? 375 TRP B CE3 1 
ATOM   5540 C  CZ2 . TRP B 1 417 ? 27.21041 32.84069  -82.32919  1.000 21.90387  ? 375 TRP B CZ2 1 
ATOM   5541 C  CZ3 . TRP B 1 417 ? 27.05091 30.57343  -81.49277  1.000 21.26320  ? 375 TRP B CZ3 1 
ATOM   5542 C  CH2 . TRP B 1 417 ? 27.43359 31.49392  -82.48241  1.000 21.60030  ? 375 TRP B CH2 1 
ATOM   5543 N  N   . ASP B 1 418 ? 28.53050 32.18645  -77.16563  1.000 20.61145  ? 376 ASP B N   1 
ATOM   5544 C  CA  . ASP B 1 418 ? 29.81411 32.89581  -77.13738  1.000 19.63324  ? 376 ASP B CA  1 
ATOM   5545 C  C   . ASP B 1 418 ? 30.27243 33.04869  -78.58374  1.000 17.47655  ? 376 ASP B C   1 
ATOM   5546 O  O   . ASP B 1 418 ? 30.81413 32.09926  -79.16579  1.000 22.55773  ? 376 ASP B O   1 
ATOM   5547 C  CB  . ASP B 1 418 ? 30.85930 32.14861  -76.30428  1.000 19.66103  ? 376 ASP B CB  1 
ATOM   5548 C  CG  . ASP B 1 418 ? 32.16542 32.93182  -76.16045  1.000 30.21997  ? 376 ASP B CG  1 
ATOM   5549 O  OD1 . ASP B 1 418 ? 32.31435 33.89397  -76.91364  1.000 25.64328  ? 376 ASP B OD1 1 
ATOM   5550 O  OD2 . ASP B 1 418 ? 33.04409 32.57868  -75.33636  1.000 19.21376  ? 376 ASP B OD2 1 
ATOM   5551 N  N   . PRO B 1 419 ? 30.09772 34.22249  -79.20257  1.000 20.29757  ? 377 PRO B N   1 
ATOM   5552 C  CA  . PRO B 1 419 ? 30.25085 34.32410  -80.66983  1.000 21.18295  ? 377 PRO B CA  1 
ATOM   5553 C  C   . PRO B 1 419 ? 31.67499 34.11006  -81.18463  1.000 18.54339  ? 377 PRO B C   1 
ATOM   5554 O  O   . PRO B 1 419 ? 31.84765 33.90547  -82.39700  1.000 22.38466  ? 377 PRO B O   1 
ATOM   5555 C  CB  . PRO B 1 419 ? 29.75018 35.74737  -80.97916  1.000 26.92700  ? 377 PRO B CB  1 
ATOM   5556 C  CG  . PRO B 1 419 ? 29.86533 36.49508  -79.67333  1.000 24.76039  ? 377 PRO B CG  1 
ATOM   5557 C  CD  . PRO B 1 419 ? 29.65019 35.48465  -78.58533  1.000 20.04630  ? 377 PRO B CD  1 
ATOM   5558 N  N   . ASN B 1 420 ? 32.69045 34.08175  -80.32266  1.000 17.23014  ? 378 ASN B N   1 
ATOM   5559 C  CA  . ASN B 1 420 ? 34.03961 33.72065  -80.75845  1.000 23.96384  ? 378 ASN B CA  1 
ATOM   5560 C  C   . ASN B 1 420 ? 34.62495 32.59881  -79.90524  1.000 29.53934  ? 378 ASN B C   1 
ATOM   5561 O  O   . ASN B 1 420 ? 35.85376 32.37942  -79.91705  1.000 27.08017  ? 378 ASN B O   1 
ATOM   5562 C  CB  . ASN B 1 420 ? 34.94981 34.94631  -80.71681  1.000 22.05204  ? 378 ASN B CB  1 
ATOM   5563 C  CG  . ASN B 1 420 ? 35.19322 35.42967  -79.30760  1.000 32.83445  ? 378 ASN B CG  1 
ATOM   5564 O  OD1 . ASN B 1 420 ? 34.50159 35.02192  -78.36546  1.000 24.07313  ? 378 ASN B OD1 1 
ATOM   5565 N  ND2 . ASN B 1 420 ? 36.17200 36.31939  -79.14625  1.000 29.36571  ? 378 ASN B ND2 1 
ATOM   5566 N  N   . GLY B 1 421 ? 33.76465 31.88170  -79.16761  1.000 28.59330  ? 379 GLY B N   1 
ATOM   5567 C  CA  . GLY B 1 421 ? 34.20742 31.00452  -78.09217  1.000 19.70607  ? 379 GLY B CA  1 
ATOM   5568 C  C   . GLY B 1 421 ? 34.77178 29.66617  -78.52042  1.000 22.10272  ? 379 GLY B C   1 
ATOM   5569 O  O   . GLY B 1 421 ? 35.41434 28.99242  -77.70339  1.000 19.01078  ? 379 GLY B O   1 
ATOM   5570 N  N   . TRP B 1 422 ? 34.54545 29.24449  -79.76306  1.000 19.89394  ? 380 TRP B N   1 
ATOM   5571 C  CA  . TRP B 1 422 ? 35.18536 28.00574  -80.18674  1.000 18.06885  ? 380 TRP B CA  1 
ATOM   5572 C  C   . TRP B 1 422 ? 36.69186 28.17546  -80.24111  1.000 26.06782  ? 380 TRP B C   1 
ATOM   5573 O  O   . TRP B 1 422 ? 37.43493 27.28838  -79.79635  1.000 27.63988  ? 380 TRP B O   1 
ATOM   5574 C  CB  . TRP B 1 422 ? 34.64626 27.54054  -81.54015  1.000 17.78249  ? 380 TRP B CB  1 
ATOM   5575 C  CG  . TRP B 1 422 ? 34.98108 26.07713  -81.82480  1.000 24.61188  ? 380 TRP B CG  1 
ATOM   5576 C  CD1 . TRP B 1 422 ? 36.05578 25.60097  -82.54228  1.000 27.25846  ? 380 TRP B CD1 1 
ATOM   5577 C  CD2 . TRP B 1 422 ? 34.25556 24.91516  -81.37999  1.000 20.37364  ? 380 TRP B CD2 1 
ATOM   5578 N  NE1 . TRP B 1 422 ? 36.04737 24.22363  -82.55211  1.000 26.62435  ? 380 TRP B NE1 1 
ATOM   5579 C  CE2 . TRP B 1 422 ? 34.95397 23.77675  -81.85594  1.000 28.58886  ? 380 TRP B CE2 1 
ATOM   5580 C  CE3 . TRP B 1 422 ? 33.09849 24.72730  -80.61236  1.000 25.64497  ? 380 TRP B CE3 1 
ATOM   5581 C  CZ2 . TRP B 1 422 ? 34.51797 22.47159  -81.61255  1.000 22.87638  ? 380 TRP B CZ2 1 
ATOM   5582 C  CZ3 . TRP B 1 422 ? 32.65366 23.42504  -80.37495  1.000 20.74128  ? 380 TRP B CZ3 1 
ATOM   5583 C  CH2 . TRP B 1 422 ? 33.36980 22.31512  -80.86585  1.000 22.47723  ? 380 TRP B CH2 1 
ATOM   5584 N  N   . THR B 1 423 ? 37.16274 29.33330  -80.72849  1.000 22.78775  ? 381 THR B N   1 
ATOM   5585 C  CA  . THR B 1 423 ? 38.58227 29.55186  -80.99985  1.000 27.36628  ? 381 THR B CA  1 
ATOM   5586 C  C   . THR B 1 423 ? 39.26920 30.62582  -80.15953  1.000 26.03962  ? 381 THR B C   1 
ATOM   5587 O  O   . THR B 1 423 ? 40.48917 30.75647  -80.27147  1.000 25.87191  ? 381 THR B O   1 
ATOM   5588 C  CB  . THR B 1 423 ? 38.78596 29.93521  -82.46848  1.000 21.51583  ? 381 THR B CB  1 
ATOM   5589 O  OG1 . THR B 1 423 ? 38.01073 31.11029  -82.74641  1.000 28.80882  ? 381 THR B OG1 1 
ATOM   5590 C  CG2 . THR B 1 423 ? 38.30936 28.80647  -83.35912  1.000 19.17019  ? 381 THR B CG2 1 
ATOM   5591 N  N   . GLU B 1 424 ? 38.54429 31.45320  -79.39918  1.000 28.63363  ? 382 GLU B N   1 
ATOM   5592 C  CA  . GLU B 1 424 ? 39.15279 32.53090  -78.61756  1.000 23.16360  ? 382 GLU B CA  1 
ATOM   5593 C  C   . GLU B 1 424 ? 38.98785 32.23807  -77.13284  1.000 24.63600  ? 382 GLU B C   1 
ATOM   5594 O  O   . GLU B 1 424 ? 38.01161 31.60973  -76.72052  1.000 21.26950  ? 382 GLU B O   1 
ATOM   5595 C  CB  . GLU B 1 424 ? 38.49677 33.89128  -78.90726  1.000 26.77153  ? 382 GLU B CB  1 
ATOM   5596 C  CG  . GLU B 1 424 ? 38.54305 34.37641  -80.35198  1.000 32.82819  ? 382 GLU B CG  1 
ATOM   5597 C  CD  . GLU B 1 424 ? 39.94344 34.39167  -80.91471  1.000 54.24407  ? 382 GLU B CD  1 
ATOM   5598 O  OE1 . GLU B 1 424 ? 40.13277 33.80043  -82.00256  1.000 55.55508  ? 382 GLU B OE1 1 
ATOM   5599 O  OE2 . GLU B 1 424 ? 40.85215 34.96500  -80.25663  1.000 56.05593  ? 382 GLU B OE2 1 
ATOM   5600 N  N   . THR B 1 425 ? 39.89696 32.76342  -76.31990  1.000 20.55449  ? 383 THR B N   1 
ATOM   5601 C  CA  . THR B 1 425 ? 40.01426 32.36760  -74.92548  1.000 19.45309  ? 383 THR B CA  1 
ATOM   5602 C  C   . THR B 1 425 ? 39.44489 33.38664  -73.95838  1.000 20.57282  ? 383 THR B C   1 
ATOM   5603 O  O   . THR B 1 425 ? 39.50183 33.16899  -72.74277  1.000 24.96972  ? 383 THR B O   1 
ATOM   5604 C  CB  . THR B 1 425 ? 41.48459 32.09803  -74.56800  1.000 26.22162  ? 383 THR B CB  1 
ATOM   5605 O  OG1 . THR B 1 425 ? 42.27963 33.21629  -74.97764  1.000 23.91783  ? 383 THR B OG1 1 
ATOM   5606 C  CG2 . THR B 1 425 ? 42.00102 30.81776  -75.25462  1.000 23.61942  ? 383 THR B CG2 1 
ATOM   5607 N  N   . ASP B 1 426 ? 38.93668 34.50797  -74.44174  1.000 19.71442  ? 384 ASP B N   1 
ATOM   5608 C  CA  . ASP B 1 426 ? 38.32167 35.43227  -73.51060  1.000 22.72354  ? 384 ASP B CA  1 
ATOM   5609 C  C   . ASP B 1 426 ? 37.02942 34.82073  -72.94509  1.000 31.49468  ? 384 ASP B C   1 
ATOM   5610 O  O   . ASP B 1 426 ? 36.48612 33.83571  -73.47062  1.000 23.74992  ? 384 ASP B O   1 
ATOM   5611 C  CB  . ASP B 1 426 ? 38.03112 36.75533  -74.21198  1.000 24.93670  ? 384 ASP B CB  1 
ATOM   5612 C  CG  . ASP B 1 426 ? 36.91528 36.61666  -75.22805  1.000 33.80844  ? 384 ASP B CG  1 
ATOM   5613 O  OD1 . ASP B 1 426 ? 35.72719 36.59703  -74.81130  1.000 42.56158  ? 384 ASP B OD1 1 
ATOM   5614 O  OD2 . ASP B 1 426 ? 37.20503 36.49609  -76.43372  1.000 34.38322  ? 384 ASP B OD2 1 
ATOM   5615 N  N   . SER B 1 427 ? 36.52419 35.43129  -71.86619  1.000 30.27912  ? 385 SER B N   1 
ATOM   5616 C  CA  . SER B 1 427 ? 35.29740 35.00382  -71.20233  1.000 31.90858  ? 385 SER B CA  1 
ATOM   5617 C  C   . SER B 1 427 ? 34.14615 35.98743  -71.40595  1.000 24.32065  ? 385 SER B C   1 
ATOM   5618 O  O   . SER B 1 427 ? 33.29427 36.13524  -70.52969  1.000 31.60018  ? 385 SER B O   1 
ATOM   5619 C  CB  . SER B 1 427 ? 35.52881 34.78724  -69.70822  1.000 33.37744  ? 385 SER B CB  1 
ATOM   5620 O  OG  . SER B 1 427 ? 36.13877 35.92246  -69.11701  1.000 31.33154  ? 385 SER B OG  1 
ATOM   5621 N  N   . SER B 1 428 ? 34.10173 36.66184  -72.54712  1.000 27.87882  ? 386 SER B N   1 
ATOM   5622 C  CA  . SER B 1 428 ? 32.96251 37.50177  -72.89424  1.000 35.54898  ? 386 SER B CA  1 
ATOM   5623 C  C   . SER B 1 428 ? 32.03266 36.72216  -73.80554  1.000 31.63579  ? 386 SER B C   1 
ATOM   5624 O  O   . SER B 1 428 ? 32.47693 36.11886  -74.78820  1.000 33.68855  ? 386 SER B O   1 
ATOM   5625 C  CB  . SER B 1 428 ? 33.37713 38.80714  -73.59027  1.000 28.39352  ? 386 SER B CB  1 
ATOM   5626 O  OG  . SER B 1 428 ? 34.02397 39.70814  -72.70333  1.000 46.92173  ? 386 SER B OG  1 
ATOM   5627 N  N   . PHE B 1 429 ? 30.74716 36.78967  -73.49960  1.000 27.20732  ? 387 PHE B N   1 
ATOM   5628 C  CA  . PHE B 1 429 ? 29.69845 36.14067  -74.25847  1.000 29.96089  ? 387 PHE B CA  1 
ATOM   5629 C  C   . PHE B 1 429 ? 28.59732 37.16608  -74.49888  1.000 27.49763  ? 387 PHE B C   1 
ATOM   5630 O  O   . PHE B 1 429 ? 28.57497 38.23237  -73.88519  1.000 31.67650  ? 387 PHE B O   1 
ATOM   5631 C  CB  . PHE B 1 429 ? 29.14298 34.91800  -73.50607  1.000 20.34382  ? 387 PHE B CB  1 
ATOM   5632 C  CG  . PHE B 1 429 ? 28.42401 35.25337  -72.21228  1.000 25.39300  ? 387 PHE B CG  1 
ATOM   5633 C  CD1 . PHE B 1 429 ? 27.04401 35.47190  -72.20681  1.000 27.71830  ? 387 PHE B CD1 1 
ATOM   5634 C  CD2 . PHE B 1 429 ? 29.09764 35.30034  -71.01087  1.000 24.63745  ? 387 PHE B CD2 1 
ATOM   5635 C  CE1 . PHE B 1 429 ? 26.35663 35.77560  -71.01864  1.000 26.03802  ? 387 PHE B CE1 1 
ATOM   5636 C  CE2 . PHE B 1 429 ? 28.42977 35.59539  -69.81812  1.000 30.75916  ? 387 PHE B CE2 1 
ATOM   5637 C  CZ  . PHE B 1 429 ? 27.05912 35.83104  -69.82626  1.000 30.13605  ? 387 PHE B CZ  1 
ATOM   5638 N  N   . SER B 1 430 ? 27.65250 36.85225  -75.38118  1.000 25.23357  ? 388 SER B N   1 
ATOM   5639 C  CA  . SER B 1 430 ? 26.61896 37.83280  -75.67104  1.000 30.03820  ? 388 SER B CA  1 
ATOM   5640 C  C   . SER B 1 430 ? 25.19884 37.43395  -75.29422  1.000 31.25581  ? 388 SER B C   1 
ATOM   5641 O  O   . SER B 1 430 ? 24.37486 38.33262  -75.12880  1.000 34.44535  ? 388 SER B O   1 
ATOM   5642 C  CB  . SER B 1 430 ? 26.66041 38.24758  -77.15156  1.000 37.50378  ? 388 SER B CB  1 
ATOM   5643 O  OG  . SER B 1 430 ? 26.65870 37.14681  -78.01304  1.000 39.91356  ? 388 SER B OG  1 
ATOM   5644 N  N   . VAL B 1 431 ? 24.87270 36.14341  -75.13619  1.000 30.90514  ? 389 VAL B N   1 
ATOM   5645 C  CA  . VAL B 1 431 ? 23.50230 35.74545  -74.78977  1.000 25.45931  ? 389 VAL B CA  1 
ATOM   5646 C  C   . VAL B 1 431 ? 23.55840 34.60626  -73.78024  1.000 22.12676  ? 389 VAL B C   1 
ATOM   5647 O  O   . VAL B 1 431 ? 24.31186 33.64232  -73.96246  1.000 19.20320  ? 389 VAL B O   1 
ATOM   5648 C  CB  . VAL B 1 431 ? 22.68925 35.31521  -76.02922  1.000 22.95814  ? 389 VAL B CB  1 
ATOM   5649 C  CG1 . VAL B 1 431 ? 21.27458 34.89448  -75.63058  1.000 28.05353  ? 389 VAL B CG1 1 
ATOM   5650 C  CG2 . VAL B 1 431 ? 22.64460 36.42197  -77.05999  1.000 31.50471  ? 389 VAL B CG2 1 
ATOM   5651 N  N   . LYS B 1 432 ? 22.78305 34.73214  -72.70405  1.000 20.42505  ? 390 LYS B N   1 
ATOM   5652 C  CA  . LYS B 1 432 ? 22.57409 33.65723  -71.74266  1.000 23.63911  ? 390 LYS B CA  1 
ATOM   5653 C  C   . LYS B 1 432 ? 21.07541 33.36012  -71.68048  1.000 22.47391  ? 390 LYS B C   1 
ATOM   5654 O  O   . LYS B 1 432 ? 20.25762 34.27876  -71.58178  1.000 21.57621  ? 390 LYS B O   1 
ATOM   5655 C  CB  . LYS B 1 432 ? 23.09455 34.04628  -70.35420  1.000 17.34538  ? 390 LYS B CB  1 
ATOM   5656 C  CG  . LYS B 1 432 ? 22.76453 33.05339  -69.25376  1.000 26.85518  ? 390 LYS B CG  1 
ATOM   5657 C  CD  . LYS B 1 432 ? 23.21190 33.51018  -67.85540  1.000 23.61317  ? 390 LYS B CD  1 
ATOM   5658 C  CE  . LYS B 1 432 ? 24.75063 33.45309  -67.70114  1.000 36.44192  ? 390 LYS B CE  1 
ATOM   5659 N  NZ  . LYS B 1 432 ? 25.19234 33.32329  -66.27753  1.000 33.01164  ? 390 LYS B NZ  1 
ATOM   5660 N  N   . GLN B 1 433 ? 20.71183 32.08031  -71.72597  1.000 21.88483  ? 391 GLN B N   1 
ATOM   5661 C  CA  . GLN B 1 433 ? 19.32365 31.65436  -71.56124  1.000 17.19437  ? 391 GLN B CA  1 
ATOM   5662 C  C   . GLN B 1 433 ? 19.24256 30.65890  -70.40965  1.000 17.34116  ? 391 GLN B C   1 
ATOM   5663 O  O   . GLN B 1 433 ? 19.85791 29.58215  -70.47996  1.000 21.92828  ? 391 GLN B O   1 
ATOM   5664 C  CB  . GLN B 1 433 ? 18.77663 31.04833  -72.85329  1.000 17.36454  ? 391 GLN B CB  1 
ATOM   5665 C  CG  . GLN B 1 433 ? 17.33187 30.57235  -72.66950  1.000 17.02821  ? 391 GLN B CG  1 
ATOM   5666 C  CD  . GLN B 1 433 ? 16.71039 30.04845  -73.90626  1.000 15.69959  ? 391 GLN B CD  1 
ATOM   5667 O  OE1 . GLN B 1 433 ? 17.25197 30.19574  -75.00735  1.000 17.85555  ? 391 GLN B OE1 1 
ATOM   5668 N  NE2 . GLN B 1 433 ? 15.53391 29.41560  -73.75006  1.000 21.55238  ? 391 GLN B NE2 1 
ATOM   5669 N  N   . ASP B 1 434 ? 18.52656 31.04572  -69.34303  1.000 16.67688  ? 392 ASP B N   1 
ATOM   5670 C  CA  . ASP B 1 434 ? 18.31724 30.21081  -68.16479  1.000 20.74440  ? 392 ASP B CA  1 
ATOM   5671 C  C   . ASP B 1 434 ? 17.47393 28.98543  -68.50559  1.000 20.06820  ? 392 ASP B C   1 
ATOM   5672 O  O   . ASP B 1 434 ? 16.47820 29.08807  -69.22159  1.000 17.81333  ? 392 ASP B O   1 
ATOM   5673 C  CB  . ASP B 1 434 ? 17.58141 30.98370  -67.07969  1.000 17.23688  ? 392 ASP B CB  1 
ATOM   5674 C  CG  . ASP B 1 434 ? 18.45103 32.02212  -66.37910  1.000 32.86322  ? 392 ASP B CG  1 
ATOM   5675 O  OD1 . ASP B 1 434 ? 19.66399 32.04318  -66.60824  1.000 25.71696  ? 392 ASP B OD1 1 
ATOM   5676 O  OD2 . ASP B 1 434 ? 17.90647 32.84328  -65.60762  1.000 36.96216  ? 392 ASP B OD2 1 
ATOM   5677 N  N   . ILE B 1 435 ? 17.85799 27.83270  -67.95292  1.000 18.37651  ? 393 ILE B N   1 
ATOM   5678 C  CA  . ILE B 1 435 ? 17.16168 26.56891  -68.17858  1.000 20.04580  ? 393 ILE B CA  1 
ATOM   5679 C  C   . ILE B 1 435 ? 16.69369 25.94793  -66.86729  1.000 20.70430  ? 393 ILE B C   1 
ATOM   5680 O  O   . ILE B 1 435 ? 15.52869 25.54734  -66.73357  1.000 23.37542  ? 393 ILE B O   1 
ATOM   5681 C  CB  . ILE B 1 435 ? 18.03933 25.58192  -68.97159  1.000 15.99559  ? 393 ILE B CB  1 
ATOM   5682 C  CG1 . ILE B 1 435 ? 18.47154 26.23809  -70.29489  1.000 17.47909  ? 393 ILE B CG1 1 
ATOM   5683 C  CG2 . ILE B 1 435 ? 17.29142 24.21217  -69.17529  1.000 16.79869  ? 393 ILE B CG2 1 
ATOM   5684 C  CD1 . ILE B 1 435 ? 17.36960 26.45625  -71.29986  1.000 16.72207  ? 393 ILE B CD1 1 
ATOM   5685 N  N   . VAL B 1 436 ? 17.58511 25.87415  -65.88287  1.000 14.90016  ? 394 VAL B N   1 
ATOM   5686 C  CA  . VAL B 1 436 ? 17.31277 25.37498  -64.53573  1.000 15.49177  ? 394 VAL B CA  1 
ATOM   5687 C  C   . VAL B 1 436 ? 18.03985 26.31056  -63.57021  1.000 21.07523  ? 394 VAL B C   1 
ATOM   5688 O  O   . VAL B 1 436 ? 19.23160 26.59400  -63.76598  1.000 14.13187  ? 394 VAL B O   1 
ATOM   5689 C  CB  . VAL B 1 436 ? 17.79935 23.91347  -64.34487  1.000 15.12387  ? 394 VAL B CB  1 
ATOM   5690 C  CG1 . VAL B 1 436 ? 17.57824 23.42964  -62.92619  1.000 11.35612  ? 394 VAL B CG1 1 
ATOM   5691 C  CG2 . VAL B 1 436 ? 17.08216 22.95774  -65.31620  1.000 14.32564  ? 394 VAL B CG2 1 
ATOM   5692 N  N   . GLY B 1 437 ? 17.33277 26.77500  -62.53174  1.000 18.12240  ? 395 GLY B N   1 
ATOM   5693 C  CA  . GLY B 1 437 ? 17.90340 27.71794  -61.59114  1.000 16.48594  ? 395 GLY B CA  1 
ATOM   5694 C  C   . GLY B 1 437 ? 19.02947 27.11567  -60.77019  1.000 17.13806  ? 395 GLY B C   1 
ATOM   5695 O  O   . GLY B 1 437 ? 19.11149 25.91326  -60.57674  1.000 18.60773  ? 395 GLY B O   1 
ATOM   5696 N  N   . ILE B 1 438 ? 19.91289 27.97891  -60.25242  1.000 15.03900  ? 396 ILE B N   1 
ATOM   5697 C  CA  . ILE B 1 438 ? 21.12727 27.51057  -59.56845  1.000 19.23210  ? 396 ILE B CA  1 
ATOM   5698 C  C   . ILE B 1 438 ? 20.80394 26.65290  -58.35489  1.000 25.32879  ? 396 ILE B C   1 
ATOM   5699 O  O   . ILE B 1 438 ? 21.59679 25.78404  -57.96559  1.000 26.59658  ? 396 ILE B O   1 
ATOM   5700 C  CB  . ILE B 1 438 ? 22.04769 28.68829  -59.18706  1.000 23.50034  ? 396 ILE B CB  1 
ATOM   5701 C  CG1 . ILE B 1 438 ? 23.36736 28.12326  -58.59178  1.000 27.28568  ? 396 ILE B CG1 1 
ATOM   5702 C  CG2 . ILE B 1 438 ? 21.29989 29.69663  -58.26466  1.000 18.26187  ? 396 ILE B CG2 1 
ATOM   5703 C  CD1 . ILE B 1 438 ? 24.58900 28.99448  -58.80097  1.000 32.76583  ? 396 ILE B CD1 1 
ATOM   5704 N  N   . ASN B 1 439 ? 19.64876 26.86215  -57.73882  1.000 25.48074  ? 397 ASN B N   1 
ATOM   5705 C  CA  . ASN B 1 439 ? 19.31084 26.10144  -56.54541  1.000 28.27670  ? 397 ASN B CA  1 
ATOM   5706 C  C   . ASN B 1 439 ? 18.65980 24.74990  -56.86392  1.000 27.53610  ? 397 ASN B C   1 
ATOM   5707 O  O   . ASN B 1 439 ? 18.21027 24.06697  -55.94295  1.000 32.37598  ? 397 ASN B O   1 
ATOM   5708 C  CB  . ASN B 1 439 ? 18.38352 26.92377  -55.63838  1.000 29.24998  ? 397 ASN B CB  1 
ATOM   5709 C  CG  . ASN B 1 439 ? 19.08707 28.14001  -55.04423  1.000 47.95683  ? 397 ASN B CG  1 
ATOM   5710 O  OD1 . ASN B 1 439 ? 20.32824 28.20545  -54.99702  1.000 46.01732  ? 397 ASN B OD1 1 
ATOM   5711 N  ND2 . ASN B 1 439 ? 18.29910 29.09248  -54.54663  1.000 59.88206  ? 397 ASN B ND2 1 
ATOM   5712 N  N   . GLU B 1 440 ? 18.55958 24.38015  -58.13539  1.000 20.64670  ? 398 GLU B N   1 
ATOM   5713 C  CA  . GLU B 1 440 ? 17.85987 23.18284  -58.57151  1.000 23.18143  ? 398 GLU B CA  1 
ATOM   5714 C  C   . GLU B 1 440 ? 18.82552 22.16038  -59.17563  1.000 19.12875  ? 398 GLU B C   1 
ATOM   5715 O  O   . GLU B 1 440 ? 19.84049 22.51054  -59.79587  1.000 17.56060  ? 398 GLU B O   1 
ATOM   5716 C  CB  . GLU B 1 440 ? 16.74961 23.56187  -59.54570  1.000 20.46244  ? 398 GLU B CB  1 
ATOM   5717 C  CG  . GLU B 1 440 ? 15.49600 24.08053  -58.80548  1.000 29.70017  ? 398 GLU B CG  1 
ATOM   5718 C  CD  . GLU B 1 440 ? 14.87241 22.98505  -57.89724  1.000 32.81508  ? 398 GLU B CD  1 
ATOM   5719 O  OE1 . GLU B 1 440 ? 15.15978 21.75257  -58.07874  1.000 38.38502  ? 398 GLU B OE1 1 
ATOM   5720 O  OE2 . GLU B 1 440 ? 14.13607 23.36017  -56.96575  1.000 45.89720  ? 398 GLU B OE2 1 
ATOM   5721 N  N   . TRP B 1 441 ? 18.48346 20.88668  -58.98502  1.000 18.81522  ? 399 TRP B N   1 
ATOM   5722 C  CA  . TRP B 1 441 ? 19.31910 19.76506  -59.39775  1.000 18.55031  ? 399 TRP B CA  1 
ATOM   5723 C  C   . TRP B 1 441 ? 19.40047 19.66471  -60.91286  1.000 19.51114  ? 399 TRP B C   1 
ATOM   5724 O  O   . TRP B 1 441 ? 18.38803 19.79145  -61.60317  1.000 16.19176  ? 399 TRP B O   1 
ATOM   5725 C  CB  . TRP B 1 441 ? 18.72186 18.48407  -58.84353  1.000 19.77158  ? 399 TRP B CB  1 
ATOM   5726 C  CG  . TRP B 1 441 ? 18.39731 18.61312  -57.40709  1.000 22.15397  ? 399 TRP B CG  1 
ATOM   5727 C  CD1 . TRP B 1 441 ? 17.13596 18.75471  -56.84334  1.000 27.61067  ? 399 TRP B CD1 1 
ATOM   5728 C  CD2 . TRP B 1 441 ? 19.32828 18.66200  -56.32834  1.000 16.53481  ? 399 TRP B CD2 1 
ATOM   5729 N  NE1 . TRP B 1 441 ? 17.24371 18.83426  -55.47700  1.000 25.41219  ? 399 TRP B NE1 1 
ATOM   5730 C  CE2 . TRP B 1 441 ? 18.57578 18.76545  -55.13434  1.000 18.89092  ? 399 TRP B CE2 1 
ATOM   5731 C  CE3 . TRP B 1 441 ? 20.71529 18.56828  -56.25111  1.000 21.50182  ? 399 TRP B CE3 1 
ATOM   5732 C  CZ2 . TRP B 1 441 ? 19.17787 18.83769  -53.89169  1.000 22.95014  ? 399 TRP B CZ2 1 
ATOM   5733 C  CZ3 . TRP B 1 441 ? 21.31078 18.61934  -55.02189  1.000 28.40193  ? 399 TRP B CZ3 1 
ATOM   5734 C  CH2 . TRP B 1 441 ? 20.55021 18.73982  -53.85532  1.000 23.29101  ? 399 TRP B CH2 1 
ATOM   5735 N  N   . SER B 1 442 ? 20.60835 19.48802  -61.44530  1.000 13.99716  ? 400 SER B N   1 
ATOM   5736 C  CA  . SER B 1 442 ? 20.67892 19.10235  -62.84604  1.000 13.96039  ? 400 SER B CA  1 
ATOM   5737 C  C   . SER B 1 442 ? 21.55709 17.85915  -62.91347  1.000 19.01662  ? 400 SER B C   1 
ATOM   5738 O  O   . SER B 1 442 ? 21.46888 17.00515  -62.01606  1.000 17.42859  ? 400 SER B O   1 
ATOM   5739 C  CB  . SER B 1 442 ? 21.16507 20.24079  -63.73864  1.000 15.93750  ? 400 SER B CB  1 
ATOM   5740 O  OG  . SER B 1 442 ? 22.42889 20.71782  -63.35366  1.000 18.59100  ? 400 SER B OG  1 
ATOM   5741 N  N   . GLY B 1 443 ? 22.40846 17.74501  -63.92034  1.000 15.68634  ? 401 GLY B N   1 
ATOM   5742 C  CA  . GLY B 1 443 ? 23.09302 16.46010  -64.13904  1.000 12.26413  ? 401 GLY B CA  1 
ATOM   5743 C  C   . GLY B 1 443 ? 23.61272 16.39902  -65.56925  1.000 20.29300  ? 401 GLY B C   1 
ATOM   5744 O  O   . GLY B 1 443 ? 23.97079 17.42631  -66.15688  1.000 22.13996  ? 401 GLY B O   1 
ATOM   5745 N  N   . TYR B 1 444 ? 23.61376 15.19060  -66.12252  1.000 19.29952  ? 402 TYR B N   1 
ATOM   5746 C  CA  . TYR B 1 444 ? 24.12135 14.98502  -67.47414  1.000 16.72851  ? 402 TYR B CA  1 
ATOM   5747 C  C   . TYR B 1 444 ? 23.30620 15.80488  -68.46963  1.000 17.95329  ? 402 TYR B C   1 
ATOM   5748 O  O   . TYR B 1 444 ? 22.14705 16.14454  -68.23120  1.000 17.15513  ? 402 TYR B O   1 
ATOM   5749 C  CB  . TYR B 1 444 ? 24.04538 13.50260  -67.86712  1.000 17.62780  ? 402 TYR B CB  1 
ATOM   5750 C  CG  . TYR B 1 444 ? 25.17341 12.64016  -67.37418  1.000 15.13259  ? 402 TYR B CG  1 
ATOM   5751 C  CD1 . TYR B 1 444 ? 25.97196 13.05736  -66.31320  1.000 20.53099  ? 402 TYR B CD1 1 
ATOM   5752 C  CD2 . TYR B 1 444 ? 25.44785 11.40385  -67.96626  1.000 17.01722  ? 402 TYR B CD2 1 
ATOM   5753 C  CE1 . TYR B 1 444 ? 27.03485 12.27990  -65.86149  1.000 22.89707  ? 402 TYR B CE1 1 
ATOM   5754 C  CE2 . TYR B 1 444 ? 26.53018 10.60725  -67.52210  1.000 22.75730  ? 402 TYR B CE2 1 
ATOM   5755 C  CZ  . TYR B 1 444 ? 27.31173 11.05928  -66.46404  1.000 20.55558  ? 402 TYR B CZ  1 
ATOM   5756 O  OH  . TYR B 1 444 ? 28.35702 10.30277  -65.98152  1.000 26.25428  ? 402 TYR B OH  1 
ATOM   5757 N  N   . SER B 1 445 ? 23.90544 16.08864  -69.61597  1.000 13.48550  ? 403 SER B N   1 
ATOM   5758 C  CA  . SER B 1 445 ? 23.15824 16.70676  -70.69643  1.000 10.66266  ? 403 SER B CA  1 
ATOM   5759 C  C   . SER B 1 445 ? 23.81131 16.27918  -71.98329  1.000 13.19681  ? 403 SER B C   1 
ATOM   5760 O  O   . SER B 1 445 ? 24.99011 15.92667  -71.99802  1.000 20.09984  ? 403 SER B O   1 
ATOM   5761 C  CB  . SER B 1 445 ? 23.16282 18.26414  -70.60797  1.000 11.62304  ? 403 SER B CB  1 
ATOM   5762 O  OG  . SER B 1 445 ? 24.53973 18.72767  -70.60947  1.000 14.70284  ? 403 SER B OG  1 
ATOM   5763 N  N   . GLY B 1 446 ? 23.06793 16.37901  -73.07630  1.000 14.07598  ? 404 GLY B N   1 
ATOM   5764 C  CA  . GLY B 1 446 ? 23.63955 15.96893  -74.33908  1.000 14.03194  ? 404 GLY B CA  1 
ATOM   5765 C  C   . GLY B 1 446 ? 22.88949 16.57743  -75.49266  1.000 17.85405  ? 404 GLY B C   1 
ATOM   5766 O  O   . GLY B 1 446 ? 21.76149 17.06786  -75.34444  1.000 17.57957  ? 404 GLY B O   1 
ATOM   5767 N  N   . SER B 1 447 ? 23.53259 16.52150  -76.65863  1.000 14.67270  ? 405 SER B N   1 
ATOM   5768 C  CA  . SER B 1 447 ? 22.94909 16.99055  -77.90478  1.000 17.09814  ? 405 SER B CA  1 
ATOM   5769 C  C   . SER B 1 447 ? 22.08399 15.91057  -78.54343  1.000 24.77416  ? 405 SER B C   1 
ATOM   5770 O  O   . SER B 1 447 ? 22.31382 14.70928  -78.36145  1.000 17.48846  ? 405 SER B O   1 
ATOM   5771 C  CB  . SER B 1 447 ? 24.05185 17.36830  -78.88924  1.000 18.48633  ? 405 SER B CB  1 
ATOM   5772 O  OG  . SER B 1 447 ? 24.90641 16.23620  -79.15470  1.000 24.26314  ? 405 SER B OG  1 
ATOM   5773 N  N   . PHE B 1 448 ? 21.09013 16.35546  -79.30810  1.000 18.36192  ? 406 PHE B N   1 
ATOM   5774 C  CA  . PHE B 1 448 ? 20.46187 15.52452  -80.32019  1.000 18.79663  ? 406 PHE B CA  1 
ATOM   5775 C  C   . PHE B 1 448 ? 19.98199 16.40838  -81.45454  1.000 19.62333  ? 406 PHE B C   1 
ATOM   5776 O  O   . PHE B 1 448 ? 19.73354 17.60394  -81.26032  1.000 20.70667  ? 406 PHE B O   1 
ATOM   5777 C  CB  . PHE B 1 448 ? 19.32750 14.68746  -79.72737  1.000 18.46584  ? 406 PHE B CB  1 
ATOM   5778 C  CG  . PHE B 1 448 ? 18.10379 15.45652  -79.30450  1.000 19.18050  ? 406 PHE B CG  1 
ATOM   5779 C  CD1 . PHE B 1 448 ? 16.97264 15.48956  -80.12917  1.000 13.16112  ? 406 PHE B CD1 1 
ATOM   5780 C  CD2 . PHE B 1 448 ? 18.03287 16.06867  -78.06221  1.000 16.80375  ? 406 PHE B CD2 1 
ATOM   5781 C  CE1 . PHE B 1 448 ? 15.78662 16.12849  -79.72216  1.000 19.48185  ? 406 PHE B CE1 1 
ATOM   5782 C  CE2 . PHE B 1 448 ? 16.84552 16.69797  -77.65098  1.000 19.10291  ? 406 PHE B CE2 1 
ATOM   5783 C  CZ  . PHE B 1 448 ? 15.72007 16.71834  -78.49460  1.000 14.92224  ? 406 PHE B CZ  1 
ATOM   5784 N  N   . VAL B 1 449 ? 19.86487 15.83248  -82.64847  1.000 15.41690  ? 407 VAL B N   1 
ATOM   5785 C  CA  . VAL B 1 449 ? 19.45253 16.62330  -83.79905  1.000 15.47322  ? 407 VAL B CA  1 
ATOM   5786 C  C   . VAL B 1 449 ? 18.10233 16.13773  -84.30990  1.000 23.74268  ? 407 VAL B C   1 
ATOM   5787 O  O   . VAL B 1 449 ? 17.66814 15.02318  -84.04405  1.000 18.31330  ? 407 VAL B O   1 
ATOM   5788 C  CB  . VAL B 1 449 ? 20.48518 16.60456  -84.93912  1.000 19.55002  ? 407 VAL B CB  1 
ATOM   5789 C  CG1 . VAL B 1 449 ? 21.70844 17.40717  -84.51533  1.000 17.88563  ? 407 VAL B CG1 1 
ATOM   5790 C  CG2 . VAL B 1 449 ? 20.87360 15.14720  -85.30962  1.000 19.07797  ? 407 VAL B CG2 1 
ATOM   5791 N  N   . GLN B 1 450 ? 17.43345 16.99662  -85.06662  1.000 16.64601  ? 408 GLN B N   1 
ATOM   5792 C  CA  . GLN B 1 450 ? 16.31996 16.54049  -85.87383  1.000 22.42125  ? 408 GLN B CA  1 
ATOM   5793 C  C   . GLN B 1 450 ? 16.71608 16.84780  -87.30239  1.000 22.68992  ? 408 GLN B C   1 
ATOM   5794 O  O   . GLN B 1 450 ? 17.05721 17.99205  -87.61859  1.000 22.20194  ? 408 GLN B O   1 
ATOM   5795 C  CB  . GLN B 1 450 ? 15.00564 17.22077  -85.46299  1.000 17.85279  ? 408 GLN B CB  1 
ATOM   5796 C  CG  . GLN B 1 450 ? 14.63140 16.96315  -84.00745  1.000 21.12577  ? 408 GLN B CG  1 
ATOM   5797 C  CD  . GLN B 1 450 ? 13.25993 17.53079  -83.62159  1.000 24.09970  ? 408 GLN B CD  1 
ATOM   5798 O  OE1 . GLN B 1 450 ? 12.88056 18.61606  -84.04784  1.000 22.29602  ? 408 GLN B OE1 1 
ATOM   5799 N  NE2 . GLN B 1 450 ? 12.52156 16.78763  -82.80901  1.000 30.08965  ? 408 GLN B NE2 1 
ATOM   5800 N  N   . HIS B 1 451 ? 16.71507 15.82423  -88.13965  1.000 24.67087  ? 409 HIS B N   1 
ATOM   5801 C  CA  . HIS B 1 451 ? 17.16616 15.92172  -89.51627  1.000 17.59797  ? 409 HIS B CA  1 
ATOM   5802 C  C   . HIS B 1 451 ? 16.09933 16.53084  -90.41468  1.000 23.63854  ? 409 HIS B C   1 
ATOM   5803 O  O   . HIS B 1 451 ? 14.89621 16.46120  -90.11670  1.000 23.05880  ? 409 HIS B O   1 
ATOM   5804 C  CB  . HIS B 1 451 ? 17.51447 14.53203  -90.05336  1.000 16.73794  ? 409 HIS B CB  1 
ATOM   5805 C  CG  . HIS B 1 451 ? 18.84343 14.01482  -89.61887  1.000 18.29197  ? 409 HIS B CG  1 
ATOM   5806 N  ND1 . HIS B 1 451 ? 19.88512 13.82383  -90.50556  1.000 20.48123  ? 409 HIS B ND1 1 
ATOM   5807 C  CD2 . HIS B 1 451 ? 19.28665 13.58613  -88.41467  1.000 21.90964  ? 409 HIS B CD2 1 
ATOM   5808 C  CE1 . HIS B 1 451 ? 20.91913 13.30631  -89.86010  1.000 20.76738  ? 409 HIS B CE1 1 
ATOM   5809 N  NE2 . HIS B 1 451 ? 20.58225 13.14847  -88.59042  1.000 20.27544  ? 409 HIS B NE2 1 
ATOM   5810 N  N   . PRO B 1 452 ? 16.51181 17.07412  -91.55779  1.000 26.49824  ? 410 PRO B N   1 
ATOM   5811 C  CA  . PRO B 1 452 ? 15.53084 17.59043  -92.52367  1.000 25.55655  ? 410 PRO B CA  1 
ATOM   5812 C  C   . PRO B 1 452 ? 14.48314 16.58548  -92.93976  1.000 26.32885  ? 410 PRO B C   1 
ATOM   5813 O  O   . PRO B 1 452 ? 13.33767 16.97746  -93.19542  1.000 29.50828  ? 410 PRO B O   1 
ATOM   5814 C  CB  . PRO B 1 452 ? 16.41474 18.00508  -93.70472  1.000 27.87196  ? 410 PRO B CB  1 
ATOM   5815 C  CG  . PRO B 1 452 ? 17.67579 18.40920  -93.05091  1.000 30.05677  ? 410 PRO B CG  1 
ATOM   5816 C  CD  . PRO B 1 452 ? 17.88797 17.43498  -91.93032  1.000 23.73932  ? 410 PRO B CD  1 
ATOM   5817 N  N   . GLU B 1 453 ? 14.84044 15.30044  -93.03373  1.000 24.37547  ? 411 GLU B N   1 
ATOM   5818 C  CA  . GLU B 1 453 ? 13.87889 14.27432  -93.42784  1.000 23.44844  ? 411 GLU B CA  1 
ATOM   5819 C  C   . GLU B 1 453 ? 12.70294 14.20175  -92.47136  1.000 28.74237  ? 411 GLU B C   1 
ATOM   5820 O  O   . GLU B 1 453 ? 11.63591 13.70883  -92.84028  1.000 27.20536  ? 411 GLU B O   1 
ATOM   5821 C  CB  . GLU B 1 453 ? 14.55068 12.89272  -93.50260  1.000 23.76966  ? 411 GLU B CB  1 
ATOM   5822 C  CG  . GLU B 1 453 ? 15.51966 12.70672  -94.68692  1.000 26.38095  ? 411 GLU B CG  1 
ATOM   5823 C  CD  . GLU B 1 453 ? 16.91994 13.32840  -94.48495  1.000 28.64342  ? 411 GLU B CD  1 
ATOM   5824 O  OE1 . GLU B 1 453 ? 17.18700 13.98450  -93.44478  1.000 28.60859  ? 411 GLU B OE1 1 
ATOM   5825 O  OE2 . GLU B 1 453 ? 17.76601 13.15906  -95.39298  1.000 32.34154  ? 411 GLU B OE2 1 
ATOM   5826 N  N   . MET B 1 454 ? 12.88711 14.64689  -91.24554  1.000 21.24591  ? 412 MET B N   1 
ATOM   5827 C  CA  . MET B 1 454 ? 11.82051 14.68038  -90.27226  1.000 26.28984  ? 412 MET B CA  1 
ATOM   5828 C  C   . MET B 1 454 ? 11.15536 16.05252  -90.17238  1.000 30.87614  ? 412 MET B C   1 
ATOM   5829 O  O   . MET B 1 454 ? 9.93210  16.14044  -90.05986  1.000 26.15668  ? 412 MET B O   1 
ATOM   5830 C  CB  . MET B 1 454 ? 12.38816 14.27733  -88.92443  1.000 24.83034  ? 412 MET B CB  1 
ATOM   5831 C  CG  . MET B 1 454 ? 11.36243 14.25345  -87.85979  1.000 40.03933  ? 412 MET B CG  1 
ATOM   5832 S  SD  . MET B 1 454 ? 12.07150 14.35142  -86.21231  1.000 40.73642  ? 412 MET B SD  1 
ATOM   5833 C  CE  . MET B 1 454 ? 11.32288 12.79413  -85.64013  1.000 28.82879  ? 412 MET B CE  1 
ATOM   5834 N  N   . THR B 1 455 ? 11.93177 17.13405  -90.22822  1.000 28.25229  ? 413 THR B N   1 
ATOM   5835 C  CA  . THR B 1 455 ? 11.38724 18.45952  -90.01565  1.000 29.40511  ? 413 THR B CA  1 
ATOM   5836 C  C   . THR B 1 455 ? 10.86891 19.10780  -91.28711  1.000 27.98154  ? 413 THR B C   1 
ATOM   5837 O  O   . THR B 1 455 ? 10.10840 20.07072  -91.19201  1.000 25.76004  ? 413 THR B O   1 
ATOM   5838 C  CB  . THR B 1 455 ? 12.45656 19.39793  -89.44003  1.000 30.13810  ? 413 THR B CB  1 
ATOM   5839 O  OG1 . THR B 1 455 ? 13.49292 19.54243  -90.41639  1.000 22.08840  ? 413 THR B OG1 1 
ATOM   5840 C  CG2 . THR B 1 455 ? 13.02486 18.86099  -88.15208  1.000 23.68072  ? 413 THR B CG2 1 
ATOM   5841 N  N   . GLY B 1 456 ? 11.33241 18.68413  -92.46338  1.000 24.98779  ? 414 GLY B N   1 
ATOM   5842 C  CA  . GLY B 1 456 ? 11.10049 19.48398  -93.65542  1.000 27.39328  ? 414 GLY B CA  1 
ATOM   5843 C  C   . GLY B 1 456 ? 11.95898 20.74313  -93.78659  1.000 33.52454  ? 414 GLY B C   1 
ATOM   5844 O  O   . GLY B 1 456 ? 11.86385 21.43566  -94.80800  1.000 29.90118  ? 414 GLY B O   1 
ATOM   5845 N  N   . LEU B 1 457 ? 12.78680 21.07518  -92.79813  1.000 27.49115  ? 415 LEU B N   1 
ATOM   5846 C  CA  . LEU B 1 457 ? 13.64346 22.25383  -92.92476  1.000 31.26094  ? 415 LEU B CA  1 
ATOM   5847 C  C   . LEU B 1 457 ? 14.80782 21.96801  -93.88473  1.000 28.43085  ? 415 LEU B C   1 
ATOM   5848 O  O   . LEU B 1 457 ? 15.05022 20.84333  -94.29715  1.000 28.33617  ? 415 LEU B O   1 
ATOM   5849 C  CB  . LEU B 1 457 ? 14.16532 22.67946  -91.55305  1.000 27.42898  ? 415 LEU B CB  1 
ATOM   5850 C  CG  . LEU B 1 457 ? 13.08101 22.90164  -90.50225  1.000 29.23679  ? 415 LEU B CG  1 
ATOM   5851 C  CD1 . LEU B 1 457 ? 13.68273 22.86402  -89.12702  1.000 29.28165  ? 415 LEU B CD1 1 
ATOM   5852 C  CD2 . LEU B 1 457 ? 12.40243 24.23043  -90.72989  1.000 27.19522  ? 415 LEU B CD2 1 
ATOM   5853 N  N   . ASP B 1 458 ? 15.53832 23.00914  -94.26158  1.000 34.75658  ? 416 ASP B N   1 
ATOM   5854 C  CA  . ASP B 1 458 ? 16.66220 22.81171  -95.16427  1.000 31.56967  ? 416 ASP B CA  1 
ATOM   5855 C  C   . ASP B 1 458 ? 17.99345 22.74259  -94.41456  1.000 35.78253  ? 416 ASP B C   1 
ATOM   5856 O  O   . ASP B 1 458 ? 19.04871 22.92617  -95.02469  1.000 36.26875  ? 416 ASP B O   1 
ATOM   5857 C  CB  . ASP B 1 458 ? 16.69850 23.92343  -96.22218  1.000 39.36979  ? 416 ASP B CB  1 
ATOM   5858 C  CG  . ASP B 1 458 ? 16.88957 25.33325  -95.61314  1.000 54.93832  ? 416 ASP B CG  1 
ATOM   5859 O  OD1 . ASP B 1 458 ? 16.88526 26.32855  -96.38247  1.000 61.33595  ? 416 ASP B OD1 1 
ATOM   5860 O  OD2 . ASP B 1 458 ? 17.06508 25.45408  -94.37646  1.000 54.76138  ? 416 ASP B OD2 1 
ATOM   5861 N  N   . CYS B 1 459 ? 17.95439 22.50173  -93.10439  1.000 25.98842  ? 417 CYS B N   1 
ATOM   5862 C  CA  . CYS B 1 459 ? 19.13141 22.55963  -92.25689  1.000 30.35455  ? 417 CYS B CA  1 
ATOM   5863 C  C   . CYS B 1 459 ? 18.97234 21.55888  -91.12436  1.000 32.90407  ? 417 CYS B C   1 
ATOM   5864 O  O   . CYS B 1 459 ? 17.88237 21.05058  -90.87099  1.000 24.10175  ? 417 CYS B O   1 
ATOM   5865 C  CB  . CYS B 1 459 ? 19.36932 23.98186  -91.71703  1.000 36.31102  ? 417 CYS B CB  1 
ATOM   5866 S  SG  . CYS B 1 459 ? 17.92415 24.80816  -90.94886  1.000 48.37298  ? 417 CYS B SG  1 
ATOM   5867 N  N   . MET B 1 460 ? 20.08276 21.29768  -90.43722  1.000 24.67902  ? 418 MET B N   1 
ATOM   5868 C  CA  . MET B 1 460 ? 20.12434 20.36228  -89.32138  1.000 23.62642  ? 418 MET B CA  1 
ATOM   5869 C  C   . MET B 1 460 ? 19.66779 21.06828  -88.05106  1.000 22.21534  ? 418 MET B C   1 
ATOM   5870 O  O   . MET B 1 460 ? 20.25841 22.07510  -87.65393  1.000 21.08383  ? 418 MET B O   1 
ATOM   5871 C  CB  . MET B 1 460 ? 21.54796 19.83578  -89.15020  1.000 23.23340  ? 418 MET B CB  1 
ATOM   5872 C  CG  . MET B 1 460 ? 21.73657 18.61370  -88.22983  1.000 25.41671  ? 418 MET B CG  1 
ATOM   5873 S  SD  . MET B 1 460 ? 20.82440 17.12663  -88.71640  1.000 28.25357  ? 418 MET B SD  1 
ATOM   5874 C  CE  . MET B 1 460 ? 21.73523 16.74383  -90.20591  1.000 23.15562  ? 418 MET B CE  1 
ATOM   5875 N  N   . ARG B 1 461 ? 18.57071 20.56666  -87.41710  1.000 20.66759  ? 419 ARG B N   1 
ATOM   5876 C  CA  . ARG B 1 461 ? 18.12962 21.28397  -86.22223  1.000 17.53583  ? 419 ARG B CA  1 
ATOM   5877 C  C   . ARG B 1 461 ? 18.84563 20.76579  -84.97948  1.000 22.72422  ? 419 ARG B C   1 
ATOM   5878 O  O   . ARG B 1 461 ? 18.78690 19.56413  -84.70740  1.000 20.36450  ? 419 ARG B O   1 
ATOM   5879 C  CB  . ARG B 1 461 ? 16.62597 21.14305  -86.01554  1.000 21.65507  ? 419 ARG B CB  1 
ATOM   5880 C  CG  . ARG B 1 461 ? 16.22013 21.46721  -84.57692  1.000 24.23933  ? 419 ARG B CG  1 
ATOM   5881 C  CD  . ARG B 1 461 ? 14.72054 21.45551  -84.35933  1.000 27.57658  ? 419 ARG B CD  1 
ATOM   5882 N  NE  . ARG B 1 461 ? 14.13858 22.70676  -84.81577  1.000 27.93227  ? 419 ARG B NE  1 
ATOM   5883 C  CZ  . ARG B 1 461 ? 12.84166 22.91288  -85.00785  1.000 27.14822  ? 419 ARG B CZ  1 
ATOM   5884 N  NH1 . ARG B 1 461 ? 11.95233 21.97275  -84.77396  1.000 25.79302  ? 419 ARG B NH1 1 
ATOM   5885 N  NH2 . ARG B 1 461 ? 12.43680 24.08371  -85.47312  1.000 28.10791  ? 419 ARG B NH2 1 
ATOM   5886 N  N   . PRO B 1 462 ? 19.47553 21.63428  -84.17352  1.000 23.46268  ? 420 PRO B N   1 
ATOM   5887 C  CA  . PRO B 1 462 ? 20.11459 21.17972  -82.93008  1.000 21.84763  ? 420 PRO B CA  1 
ATOM   5888 C  C   . PRO B 1 462 ? 19.15525 21.24229  -81.75028  1.000 21.20959  ? 420 PRO B C   1 
ATOM   5889 O  O   . PRO B 1 462 ? 18.38572 22.18538  -81.58542  1.000 20.68174  ? 420 PRO B O   1 
ATOM   5890 C  CB  . PRO B 1 462 ? 21.26064 22.18997  -82.75493  1.000 19.28676  ? 420 PRO B CB  1 
ATOM   5891 C  CG  . PRO B 1 462 ? 20.65171 23.48636  -83.29340  1.000 18.86371  ? 420 PRO B CG  1 
ATOM   5892 C  CD  . PRO B 1 462 ? 19.71941 23.07267  -84.42363  1.000 20.79850  ? 420 PRO B CD  1 
ATOM   5893 N  N   . CYS B 1 463 ? 19.24076 20.23759  -80.89114  1.000 18.31651  ? 421 CYS B N   1 
ATOM   5894 C  CA  . CYS B 1 463 ? 18.42490 20.14971  -79.69990  1.000 16.81877  ? 421 CYS B CA  1 
ATOM   5895 C  C   . CYS B 1 463 ? 19.30914 19.63153  -78.57309  1.000 18.78526  ? 421 CYS B C   1 
ATOM   5896 O  O   . CYS B 1 463 ? 20.43718 19.18293  -78.79217  1.000 21.28728  ? 421 CYS B O   1 
ATOM   5897 C  CB  . CYS B 1 463 ? 17.20248 19.22289  -79.89796  1.000 16.86730  ? 421 CYS B CB  1 
ATOM   5898 S  SG  . CYS B 1 463 ? 16.09082 19.52369  -81.29852  1.000 22.42163  ? 421 CYS B SG  1 
ATOM   5899 N  N   . PHE B 1 464 ? 18.80246 19.68961  -77.34835  1.000 17.64082  ? 422 PHE B N   1 
ATOM   5900 C  CA  . PHE B 1 464 ? 19.56849 19.10057  -76.26329  1.000 14.24742  ? 422 PHE B CA  1 
ATOM   5901 C  C   . PHE B 1 464 ? 18.61146 18.64039  -75.17277  1.000 19.09046  ? 422 PHE B C   1 
ATOM   5902 O  O   . PHE B 1 464 ? 17.45892 19.10309  -75.07457  1.000 15.30872  ? 422 PHE B O   1 
ATOM   5903 C  CB  . PHE B 1 464 ? 20.62510 20.08986  -75.71931  1.000 17.11032  ? 422 PHE B CB  1 
ATOM   5904 C  CG  . PHE B 1 464 ? 20.04224 21.23312  -74.95925  1.000 17.34088  ? 422 PHE B CG  1 
ATOM   5905 C  CD1 . PHE B 1 464 ? 19.88598 21.16596  -73.57709  1.000 14.91488  ? 422 PHE B CD1 1 
ATOM   5906 C  CD2 . PHE B 1 464 ? 19.68717 22.39613  -75.61600  1.000 17.34712  ? 422 PHE B CD2 1 
ATOM   5907 C  CE1 . PHE B 1 464 ? 19.32265 22.23592  -72.86944  1.000 13.75461  ? 422 PHE B CE1 1 
ATOM   5908 C  CE2 . PHE B 1 464 ? 19.15506 23.47527  -74.91239  1.000 17.38155  ? 422 PHE B CE2 1 
ATOM   5909 C  CZ  . PHE B 1 464 ? 18.96067 23.37747  -73.53999  1.000 18.65313  ? 422 PHE B CZ  1 
ATOM   5910 N  N   . TRP B 1 465 ? 19.09616 17.70172  -74.36405  1.000 13.69169  ? 423 TRP B N   1 
ATOM   5911 C  CA  . TRP B 1 465 ? 18.35231 17.20278  -73.22728  1.000 10.71680  ? 423 TRP B CA  1 
ATOM   5912 C  C   . TRP B 1 465 ? 19.17405 17.46393  -71.99480  1.000 12.25858  ? 423 TRP B C   1 
ATOM   5913 O  O   . TRP B 1 465 ? 20.39785 17.60529  -72.05984  1.000 12.42190  ? 423 TRP B O   1 
ATOM   5914 C  CB  . TRP B 1 465 ? 18.01896 15.69069  -73.33565  1.000 16.50758  ? 423 TRP B CB  1 
ATOM   5915 C  CG  . TRP B 1 465 ? 19.23301 14.85074  -73.61077  1.000 13.82819  ? 423 TRP B CG  1 
ATOM   5916 C  CD1 . TRP B 1 465 ? 19.70331 14.47746  -74.83139  1.000 16.89030  ? 423 TRP B CD1 1 
ATOM   5917 C  CD2 . TRP B 1 465 ? 20.11252 14.27844  -72.64594  1.000 14.58453  ? 423 TRP B CD2 1 
ATOM   5918 N  NE1 . TRP B 1 465 ? 20.82648 13.69132  -74.69867  1.000 13.69173  ? 423 TRP B NE1 1 
ATOM   5919 C  CE2 . TRP B 1 465 ? 21.11965 13.58009  -73.36351  1.000 15.28576  ? 423 TRP B CE2 1 
ATOM   5920 C  CE3 . TRP B 1 465 ? 20.15901 14.29416  -71.24874  1.000 15.39599  ? 423 TRP B CE3 1 
ATOM   5921 C  CZ2 . TRP B 1 465 ? 22.16175 12.90007  -72.73465  1.000 16.91777  ? 423 TRP B CZ2 1 
ATOM   5922 C  CZ3 . TRP B 1 465 ? 21.23119 13.61326  -70.60743  1.000 16.50496  ? 423 TRP B CZ3 1 
ATOM   5923 C  CH2 . TRP B 1 465 ? 22.21506 12.94255  -71.35948  1.000 16.12586  ? 423 TRP B CH2 1 
ATOM   5924 N  N   . VAL B 1 466 ? 18.49694 17.53841  -70.86531  1.000 13.66682  ? 424 VAL B N   1 
ATOM   5925 C  CA  . VAL B 1 466 ? 19.15464 17.68135  -69.57554  1.000 15.20491  ? 424 VAL B CA  1 
ATOM   5926 C  C   . VAL B 1 466 ? 18.58801 16.63512  -68.63463  1.000 18.36843  ? 424 VAL B C   1 
ATOM   5927 O  O   . VAL B 1 466 ? 17.37358 16.39862  -68.60803  1.000 18.42123  ? 424 VAL B O   1 
ATOM   5928 C  CB  . VAL B 1 466 ? 18.95552 19.08423  -68.96633  1.000 15.33817  ? 424 VAL B CB  1 
ATOM   5929 C  CG1 . VAL B 1 466 ? 19.82923 19.21516  -67.69840  1.000 15.14343  ? 424 VAL B CG1 1 
ATOM   5930 C  CG2 . VAL B 1 466 ? 19.29490 20.15540  -69.99154  1.000 15.33663  ? 424 VAL B CG2 1 
ATOM   5931 N  N   . GLU B 1 467 ? 19.46398 16.02285  -67.85188  1.000 17.11322  ? 425 GLU B N   1 
ATOM   5932 C  CA  . GLU B 1 467 ? 19.07577 15.04453  -66.86305  1.000 15.07499  ? 425 GLU B CA  1 
ATOM   5933 C  C   . GLU B 1 467 ? 19.07006 15.73390  -65.51615  1.000 14.56637  ? 425 GLU B C   1 
ATOM   5934 O  O   . GLU B 1 467 ? 20.03304 16.41494  -65.16734  1.000 16.99370  ? 425 GLU B O   1 
ATOM   5935 C  CB  . GLU B 1 467 ? 20.04286 13.85859  -66.87397  1.000 17.08989  ? 425 GLU B CB  1 
ATOM   5936 C  CG  . GLU B 1 467 ? 19.86861 12.87703  -65.72087  1.000 16.49614  ? 425 GLU B CG  1 
ATOM   5937 C  CD  . GLU B 1 467 ? 21.10341 11.98657  -65.54946  1.000 33.06623  ? 425 GLU B CD  1 
ATOM   5938 O  OE1 . GLU B 1 467 ? 22.25308 12.53258  -65.47035  1.000 20.33718  ? 425 GLU B OE1 1 
ATOM   5939 O  OE2 . GLU B 1 467 ? 20.91533 10.74722  -65.48620  1.000 20.27173  ? 425 GLU B OE2 1 
ATOM   5940 N  N   . LEU B 1 468 ? 17.98145 15.57778  -64.76890  1.000 13.80917  ? 426 LEU B N   1 
ATOM   5941 C  CA  . LEU B 1 468 ? 17.81892 16.26458  -63.49765  1.000 15.43700  ? 426 LEU B CA  1 
ATOM   5942 C  C   . LEU B 1 468 ? 17.93632 15.19242  -62.42738  1.000 19.38766  ? 426 LEU B C   1 
ATOM   5943 O  O   . LEU B 1 468 ? 16.98088 14.44031  -62.17475  1.000 13.34250  ? 426 LEU B O   1 
ATOM   5944 C  CB  . LEU B 1 468 ? 16.48810 17.01017  -63.45259  1.000 16.46160  ? 426 LEU B CB  1 
ATOM   5945 C  CG  . LEU B 1 468 ? 16.18053 17.87535  -64.69614  1.000 22.84393  ? 426 LEU B CG  1 
ATOM   5946 C  CD1 . LEU B 1 468 ? 14.76315 18.48895  -64.63964  1.000 18.58292  ? 426 LEU B CD1 1 
ATOM   5947 C  CD2 . LEU B 1 468 ? 17.21614 18.96923  -64.93716  1.000 18.91077  ? 426 LEU B CD2 1 
ATOM   5948 N  N   . ILE B 1 469 ? 19.10811 15.12922  -61.79483  1.000 14.66316  ? 427 ILE B N   1 
ATOM   5949 C  CA  . ILE B 1 469 ? 19.45837 14.00939  -60.93615  1.000 16.25989  ? 427 ILE B CA  1 
ATOM   5950 C  C   . ILE B 1 469 ? 18.94402 14.28238  -59.53657  1.000 21.13466  ? 427 ILE B C   1 
ATOM   5951 O  O   . ILE B 1 469 ? 19.19130 15.35226  -58.96614  1.000 19.22856  ? 427 ILE B O   1 
ATOM   5952 C  CB  . ILE B 1 469 ? 20.97794 13.77158  -60.91635  1.000 15.67546  ? 427 ILE B CB  1 
ATOM   5953 C  CG1 . ILE B 1 469 ? 21.46445 13.39168  -62.31364  1.000 15.23650  ? 427 ILE B CG1 1 
ATOM   5954 C  CG2 . ILE B 1 469 ? 21.27177 12.70578  -59.89747  1.000 18.97834  ? 427 ILE B CG2 1 
ATOM   5955 C  CD1 . ILE B 1 469 ? 22.99501 13.31407  -62.41299  1.000 24.51201  ? 427 ILE B CD1 1 
ATOM   5956 N  N   . ARG B 1 470 ? 18.23695 13.31019  -58.97808  1.000 10.13237  ? 428 ARG B N   1 
ATOM   5957 C  CA  . ARG B 1 470 ? 17.72876 13.35776  -57.61675  1.000 15.07171  ? 428 ARG B CA  1 
ATOM   5958 C  C   . ARG B 1 470 ? 18.24851 12.16866  -56.81979  1.000 16.96770  ? 428 ARG B C   1 
ATOM   5959 O  O   . ARG B 1 470 ? 18.45257 11.07652  -57.36041  1.000 14.71713  ? 428 ARG B O   1 
ATOM   5960 C  CB  . ARG B 1 470 ? 16.18609 13.33601  -57.60761  1.000 11.26929  ? 428 ARG B CB  1 
ATOM   5961 C  CG  . ARG B 1 470 ? 15.59739 14.48019  -58.42030  1.000 18.32892  ? 428 ARG B CG  1 
ATOM   5962 C  CD  . ARG B 1 470 ? 16.02028 15.88052  -57.93042  1.000 14.85463  ? 428 ARG B CD  1 
ATOM   5963 N  NE  . ARG B 1 470 ? 15.76080 16.10584  -56.50904  1.000 22.04161  ? 428 ARG B NE  1 
ATOM   5964 C  CZ  . ARG B 1 470 ? 14.59812 16.50602  -56.00707  1.000 20.14321  ? 428 ARG B CZ  1 
ATOM   5965 N  NH1 . ARG B 1 470 ? 13.55143 16.72403  -56.78548  1.000 14.89225  ? 428 ARG B NH1 1 
ATOM   5966 N  NH2 . ARG B 1 470 ? 14.47506 16.65840  -54.68901  1.000 18.84597  ? 428 ARG B NH2 1 
ATOM   5967 N  N   . GLY B 1 471 ? 18.39334 12.37038  -55.52264  1.000 14.41526  ? 429 GLY B N   1 
ATOM   5968 C  CA  . GLY B 1 471 ? 18.75728 11.28805  -54.64094  1.000 14.13138  ? 429 GLY B CA  1 
ATOM   5969 C  C   . GLY B 1 471 ? 20.21709 11.35931  -54.21878  1.000 22.24494  ? 429 GLY B C   1 
ATOM   5970 O  O   . GLY B 1 471 ? 20.75378 12.43084  -53.96015  1.000 15.59118  ? 429 GLY B O   1 
ATOM   5971 N  N   . ARG B 1 472 ? 20.85994 10.20982  -54.11664  1.000 21.47318  ? 430 ARG B N   1 
ATOM   5972 C  CA  . ARG B 1 472 ? 22.25673 10.13999  -53.71670  1.000 18.09355  ? 430 ARG B CA  1 
ATOM   5973 C  C   . ARG B 1 472 ? 23.16708 10.73784  -54.78490  1.000 19.28835  ? 430 ARG B C   1 
ATOM   5974 O  O   . ARG B 1 472 ? 22.86924 10.64704  -55.97937  1.000 16.43433  ? 430 ARG B O   1 
ATOM   5975 C  CB  . ARG B 1 472 ? 22.61780 8.67400   -53.47800  1.000 18.74563  ? 430 ARG B CB  1 
ATOM   5976 C  CG  . ARG B 1 472 ? 22.16847 8.14180   -52.11178  1.000 24.41630  ? 430 ARG B CG  1 
ATOM   5977 C  CD  . ARG B 1 472 ? 22.33585 6.61371   -52.00253  1.000 28.35456  ? 430 ARG B CD  1 
ATOM   5978 N  NE  . ARG B 1 472 ? 23.52958 6.16796   -52.72873  1.000 58.78552  ? 430 ARG B NE  1 
ATOM   5979 C  CZ  . ARG B 1 472 ? 24.02601 4.93370   -52.72336  1.000 59.01619  ? 430 ARG B CZ  1 
ATOM   5980 N  NH1 . ARG B 1 472 ? 23.55312 4.00309   -51.90720  1.000 47.28967  ? 430 ARG B NH1 1 
ATOM   5981 N  NH2 . ARG B 1 472 ? 24.99244 4.61499   -53.59106  1.000 43.28353  ? 430 ARG B NH2 1 
ATOM   5982 N  N   . PRO B 1 473 ? 24.33284 11.31784  -54.38445  1.000 22.90474  ? 431 PRO B N   1 
ATOM   5983 C  CA  . PRO B 1 473 ? 24.83307 11.50198  -53.01307  1.000 21.60115  ? 431 PRO B CA  1 
ATOM   5984 C  C   . PRO B 1 473 ? 24.28633 12.76211  -52.35858  1.000 19.17041  ? 431 PRO B C   1 
ATOM   5985 O  O   . PRO B 1 473 ? 24.53528 12.95826  -51.17463  1.000 24.26858  ? 431 PRO B O   1 
ATOM   5986 C  CB  . PRO B 1 473 ? 26.36991 11.61092  -53.21497  1.000 16.71228  ? 431 PRO B CB  1 
ATOM   5987 C  CG  . PRO B 1 473 ? 26.47781 12.38690  -54.52252  1.000 16.27380  ? 431 PRO B CG  1 
ATOM   5988 C  CD  . PRO B 1 473 ? 25.28919 11.86672  -55.37649  1.000 24.68664  ? 431 PRO B CD  1 
ATOM   5989 N  N   . LYS B 1 474 ? 23.58096 13.65586  -53.07173  1.000 21.28376  ? 432 LYS B N   1 
ATOM   5990 C  CA  . LYS B 1 474 ? 23.20742 14.95007  -52.48529  1.000 23.88747  ? 432 LYS B CA  1 
ATOM   5991 C  C   . LYS B 1 474 ? 22.00394 14.89788  -51.53674  1.000 25.77493  ? 432 LYS B C   1 
ATOM   5992 O  O   . LYS B 1 474 ? 21.88632 15.77042  -50.67179  1.000 17.90110  ? 432 LYS B O   1 
ATOM   5993 C  CB  . LYS B 1 474 ? 22.93304 15.98165  -53.58883  1.000 27.49122  ? 432 LYS B CB  1 
ATOM   5994 C  CG  . LYS B 1 474 ? 24.15676 16.27625  -54.43978  1.000 21.99030  ? 432 LYS B CG  1 
ATOM   5995 C  CD  . LYS B 1 474 ? 25.32451 16.56694  -53.49873  1.000 34.60340  ? 432 LYS B CD  1 
ATOM   5996 C  CE  . LYS B 1 474 ? 26.69451 16.55415  -54.18824  1.000 43.28360  ? 432 LYS B CE  1 
ATOM   5997 N  NZ  . LYS B 1 474 ? 27.01802 17.87789  -54.76200  1.000 39.98578  ? 432 LYS B NZ  1 
ATOM   5998 N  N   . GLU B 1 475 ? 21.12906 13.89161  -51.62101  1.000 17.74053  ? 433 GLU B N   1 
ATOM   5999 C  CA  . GLU B 1 475 ? 19.91972 13.89649  -50.79866  1.000 15.72696  ? 433 GLU B CA  1 
ATOM   6000 C  C   . GLU B 1 475 ? 19.77667 12.58802  -50.00762  1.000 21.20318  ? 433 GLU B C   1 
ATOM   6001 O  O   . GLU B 1 475 ? 20.49709 11.61863  -50.23051  1.000 17.33752  ? 433 GLU B O   1 
ATOM   6002 C  CB  . GLU B 1 475 ? 18.68986 14.16374  -51.67927  1.000 16.62371  ? 433 GLU B CB  1 
ATOM   6003 C  CG  . GLU B 1 475 ? 18.86094 15.40316  -52.54126  1.000 22.18026  ? 433 GLU B CG  1 
ATOM   6004 C  CD  . GLU B 1 475 ? 17.72644 15.58681  -53.50508  1.000 21.78499  ? 433 GLU B CD  1 
ATOM   6005 O  OE1 . GLU B 1 475 ? 16.65316 16.04893  -53.07305  1.000 21.47946  ? 433 GLU B OE1 1 
ATOM   6006 O  OE2 . GLU B 1 475 ? 17.90082 15.24289  -54.69374  1.000 22.14555  ? 433 GLU B OE2 1 
ATOM   6007 N  N   . ASN B 1 476 ? 18.88290 12.60144  -49.01911  1.000 18.98704  ? 434 ASN B N   1 
ATOM   6008 C  CA  . ASN B 1 476 ? 18.72834 11.53567  -48.01947  1.000 20.98372  ? 434 ASN B CA  1 
ATOM   6009 C  C   . ASN B 1 476 ? 17.80408 10.41456  -48.50335  1.000 19.59495  ? 434 ASN B C   1 
ATOM   6010 O  O   . ASN B 1 476 ? 16.73250 10.14665  -47.92119  1.000 19.96738  ? 434 ASN B O   1 
ATOM   6011 C  CB  . ASN B 1 476 ? 18.18783 12.12746  -46.72880  1.000 17.15433  ? 434 ASN B CB  1 
ATOM   6012 C  CG  . ASN B 1 476 ? 19.25596 12.81276  -45.92276  1.000 28.97672  ? 434 ASN B CG  1 
ATOM   6013 O  OD1 . ASN B 1 476 ? 20.44462 12.50914  -46.07577  1.000 23.13189  ? 434 ASN B OD1 1 
ATOM   6014 N  ND2 . ASN B 1 476 ? 18.84855 13.75550  -45.06434  1.000 20.75273  ? 434 ASN B ND2 1 
ATOM   6015 N  N   . THR B 1 477 ? 18.23155 9.76108   -49.57720  1.000 15.10267  ? 435 THR B N   1 
ATOM   6016 C  CA  . THR B 1 477 ? 17.49521 8.65765   -50.18705  1.000 20.48839  ? 435 THR B CA  1 
ATOM   6017 C  C   . THR B 1 477 ? 18.41025 7.44506   -50.24471  1.000 23.12830  ? 435 THR B C   1 
ATOM   6018 O  O   . THR B 1 477 ? 19.60761 7.56084   -50.01849  1.000 17.03485  ? 435 THR B O   1 
ATOM   6019 C  CB  . THR B 1 477 ? 17.03705 9.00895   -51.60485  1.000 18.04615  ? 435 THR B CB  1 
ATOM   6020 O  OG1 . THR B 1 477 ? 18.20979 9.34684   -52.39150  1.000 18.67633  ? 435 THR B OG1 1 
ATOM   6021 C  CG2 . THR B 1 477 ? 16.05158 10.22378  -51.58191  1.000 16.49434  ? 435 THR B CG2 1 
ATOM   6022 N  N   . ILE B 1 478 ? 17.83325 6.26855   -50.54265  1.000 17.13095  ? 436 ILE B N   1 
ATOM   6023 C  CA  . ILE B 1 478 ? 18.63028 5.06899   -50.80680  1.000 15.94933  ? 436 ILE B CA  1 
ATOM   6024 C  C   . ILE B 1 478 ? 18.97088 4.95006   -52.27677  1.000 22.24852  ? 436 ILE B C   1 
ATOM   6025 O  O   . ILE B 1 478 ? 19.74260 4.05208   -52.65873  1.000 18.25311  ? 436 ILE B O   1 
ATOM   6026 C  CB  . ILE B 1 478 ? 17.90410 3.77183   -50.39723  1.000 23.62369  ? 436 ILE B CB  1 
ATOM   6027 C  CG1 . ILE B 1 478 ? 16.67837 3.51480   -51.29847  1.000 19.20100  ? 436 ILE B CG1 1 
ATOM   6028 C  CG2 . ILE B 1 478 ? 17.47287 3.84696   -48.96965  1.000 21.09825  ? 436 ILE B CG2 1 
ATOM   6029 C  CD1 . ILE B 1 478 ? 15.95436 2.16878   -50.98428  1.000 21.17866  ? 436 ILE B CD1 1 
ATOM   6030 N  N   . TRP B 1 479 ? 18.41300 5.82727   -53.11533  1.000 17.01710  ? 437 TRP B N   1 
ATOM   6031 C  CA  . TRP B 1 479 ? 18.40010 5.66582   -54.55451  1.000 17.79037  ? 437 TRP B CA  1 
ATOM   6032 C  C   . TRP B 1 479 ? 18.89459 6.92926   -55.24315  1.000 14.95154  ? 437 TRP B C   1 
ATOM   6033 O  O   . TRP B 1 479 ? 18.99935 7.99466   -54.63407  1.000 15.19261  ? 437 TRP B O   1 
ATOM   6034 C  CB  . TRP B 1 479 ? 16.97906 5.33109   -55.02333  1.000 16.77263  ? 437 TRP B CB  1 
ATOM   6035 C  CG  . TRP B 1 479 ? 15.94047 6.31837   -54.55064  1.000 18.99958  ? 437 TRP B CG  1 
ATOM   6036 C  CD1 . TRP B 1 479 ? 15.24521 6.32364   -53.34278  1.000 18.00848  ? 437 TRP B CD1 1 
ATOM   6037 C  CD2 . TRP B 1 479 ? 15.48715 7.44452   -55.27564  1.000 14.73833  ? 437 TRP B CD2 1 
ATOM   6038 N  NE1 . TRP B 1 479 ? 14.39674 7.40609   -53.29740  1.000 19.85141  ? 437 TRP B NE1 1 
ATOM   6039 C  CE2 . TRP B 1 479 ? 14.52327 8.10930   -54.47285  1.000 15.53628  ? 437 TRP B CE2 1 
ATOM   6040 C  CE3 . TRP B 1 479 ? 15.80335 7.97215   -56.53415  1.000 19.58020  ? 437 TRP B CE3 1 
ATOM   6041 C  CZ2 . TRP B 1 479 ? 13.88498 9.27565   -54.89399  1.000 18.20746  ? 437 TRP B CZ2 1 
ATOM   6042 C  CZ3 . TRP B 1 479 ? 15.16295 9.12510   -56.94881  1.000 18.56214  ? 437 TRP B CZ3 1 
ATOM   6043 C  CH2 . TRP B 1 479 ? 14.20182 9.75521   -56.13367  1.000 20.35986  ? 437 TRP B CH2 1 
ATOM   6044 N  N   . THR B 1 480 ? 19.17002 6.79390   -56.54214  1.000 15.20635  ? 438 THR B N   1 
ATOM   6045 C  CA  . THR B 1 480 ? 19.47603 7.92696   -57.41668  1.000 17.76935  ? 438 THR B CA  1 
ATOM   6046 C  C   . THR B 1 480 ? 18.72385 7.72334   -58.71816  1.000 19.89358  ? 438 THR B C   1 
ATOM   6047 O  O   . THR B 1 480 ? 18.74464 6.62534   -59.27068  1.000 17.66276  ? 438 THR B O   1 
ATOM   6048 C  CB  . THR B 1 480 ? 20.97985 8.03041   -57.73148  1.000 20.37066  ? 438 THR B CB  1 
ATOM   6049 O  OG1 . THR B 1 480 ? 21.71947 8.16503   -56.50985  1.000 17.45771  ? 438 THR B OG1 1 
ATOM   6050 C  CG2 . THR B 1 480 ? 21.24450 9.18256   -58.64387  1.000 15.62829  ? 438 THR B CG2 1 
ATOM   6051 N  N   . SER B 1 481 ? 18.06201 8.76411   -59.21204  1.000 14.77590  ? 439 SER B N   1 
ATOM   6052 C  CA  . SER B 1 481 ? 17.44216 8.69168   -60.52767  1.000 17.18780  ? 439 SER B CA  1 
ATOM   6053 C  C   . SER B 1 481 ? 17.49715 10.07429  -61.15161  1.000 17.84453  ? 439 SER B C   1 
ATOM   6054 O  O   . SER B 1 481 ? 17.87775 11.05034  -60.49210  1.000 21.02284  ? 439 SER B O   1 
ATOM   6055 C  CB  . SER B 1 481 ? 15.98893 8.15301   -60.43823  1.000 14.84131  ? 439 SER B CB  1 
ATOM   6056 O  OG  . SER B 1 481 ? 15.46829 7.89595   -61.74128  1.000 13.63091  ? 439 SER B OG  1 
ATOM   6057 N  N   . GLY B 1 482 ? 17.18577 10.13849  -62.44859  1.000 15.98844  ? 440 GLY B N   1 
ATOM   6058 C  CA  . GLY B 1 482 ? 17.01115 11.40342  -63.14583  1.000 15.46723  ? 440 GLY B CA  1 
ATOM   6059 C  C   . GLY B 1 482 ? 15.65505 11.48133  -63.82451  1.000 18.48082  ? 440 GLY B C   1 
ATOM   6060 O  O   . GLY B 1 482 ? 15.09981 10.46660  -64.23851  1.000 21.56468  ? 440 GLY B O   1 
ATOM   6061 N  N   . SER B 1 483 ? 15.08626 12.70100  -63.89224  1.000 15.86516  ? 441 SER B N   1 
ATOM   6062 C  CA  . SER B 1 483 ? 14.02676 12.95804  -64.86267  1.000 19.12627  ? 441 SER B CA  1 
ATOM   6063 C  C   . SER B 1 483 ? 14.63998 13.78318  -65.98540  1.000 20.27352  ? 441 SER B C   1 
ATOM   6064 O  O   . SER B 1 483 ? 15.82745 14.09193  -65.94869  1.000 24.69532  ? 441 SER B O   1 
ATOM   6065 C  CB  . SER B 1 483 ? 12.81345 13.62767  -64.21791  1.000 17.90564  ? 441 SER B CB  1 
ATOM   6066 O  OG  . SER B 1 483 ? 13.02727 14.97996  -63.89298  1.000 23.92006  ? 441 SER B OG  1 
ATOM   6067 N  N   . SER B 1 484 ? 13.87251 14.13065  -67.01390  1.000 15.68227  ? 442 SER B N   1 
ATOM   6068 C  CA  . SER B 1 484 ? 14.53422 14.90394  -68.06588  1.000 18.70519  ? 442 SER B CA  1 
ATOM   6069 C  C   . SER B 1 484 ? 13.68621 16.06471  -68.58583  1.000 22.63244  ? 442 SER B C   1 
ATOM   6070 O  O   . SER B 1 484 ? 12.45686 16.13953  -68.40869  1.000 19.80133  ? 442 SER B O   1 
ATOM   6071 C  CB  . SER B 1 484 ? 14.97139 14.02127  -69.24257  1.000 25.06332  ? 442 SER B CB  1 
ATOM   6072 O  OG  . SER B 1 484 ? 13.88295 13.58745  -70.01689  1.000 22.07167  ? 442 SER B OG  1 
ATOM   6073 N  N   . ILE B 1 485 ? 14.39940 16.99731  -69.20866  1.000 17.18599  ? 443 ILE B N   1 
ATOM   6074 C  CA  . ILE B 1 485 ? 13.82727 18.09556  -69.96241  1.000 15.86190  ? 443 ILE B CA  1 
ATOM   6075 C  C   . ILE B 1 485 ? 14.62854 18.15164  -71.24795  1.000 19.80291  ? 443 ILE B C   1 
ATOM   6076 O  O   . ILE B 1 485 ? 15.79150 17.72512  -71.29050  1.000 22.02634  ? 443 ILE B O   1 
ATOM   6077 C  CB  . ILE B 1 485 ? 13.86980 19.44676  -69.19073  1.000 18.51453  ? 443 ILE B CB  1 
ATOM   6078 C  CG1 . ILE B 1 485 ? 15.30734 19.83868  -68.80045  1.000 15.85353  ? 443 ILE B CG1 1 
ATOM   6079 C  CG2 . ILE B 1 485 ? 12.94299 19.41773  -67.95348  1.000 19.15588  ? 443 ILE B CG2 1 
ATOM   6080 C  CD1 . ILE B 1 485 ? 15.46213 21.16567  -68.06253  1.000 14.03252  ? 443 ILE B CD1 1 
ATOM   6081 N  N   . SER B 1 486 ? 14.00839 18.66279  -72.30462  1.000 17.86854  ? 444 SER B N   1 
ATOM   6082 C  CA  . SER B 1 486 ? 14.74198 18.87435  -73.53844  1.000 20.78013  ? 444 SER B CA  1 
ATOM   6083 C  C   . SER B 1 486 ? 14.24400 20.13959  -74.21685  1.000 18.28205  ? 444 SER B C   1 
ATOM   6084 O  O   . SER B 1 486 ? 13.18194 20.67034  -73.89230  1.000 15.96577  ? 444 SER B O   1 
ATOM   6085 C  CB  . SER B 1 486 ? 14.63318 17.67803  -74.48125  1.000 17.56309  ? 444 SER B CB  1 
ATOM   6086 O  OG  . SER B 1 486 ? 13.33762 17.55705  -75.01122  1.000 15.72210  ? 444 SER B OG  1 
ATOM   6087 N  N   . PHE B 1 487 ? 15.05853 20.63102  -75.14483  1.000 13.78486  ? 445 PHE B N   1 
ATOM   6088 C  CA  . PHE B 1 487 ? 14.85298 21.90693  -75.82222  1.000 20.03903  ? 445 PHE B CA  1 
ATOM   6089 C  C   . PHE B 1 487 ? 15.34682 21.79949  -77.25411  1.000 20.27633  ? 445 PHE B C   1 
ATOM   6090 O  O   . PHE B 1 487 ? 16.34080 21.11438  -77.52363  1.000 19.92395  ? 445 PHE B O   1 
ATOM   6091 C  CB  . PHE B 1 487 ? 15.61740 23.04737  -75.13185  1.000 13.25409  ? 445 PHE B CB  1 
ATOM   6092 C  CG  . PHE B 1 487 ? 15.16894 23.32802  -73.74024  1.000 14.27959  ? 445 PHE B CG  1 
ATOM   6093 C  CD1 . PHE B 1 487 ? 15.55412 22.51046  -72.68706  1.000 13.35176  ? 445 PHE B CD1 1 
ATOM   6094 C  CD2 . PHE B 1 487 ? 14.40327 24.45391  -73.48314  1.000 16.35734  ? 445 PHE B CD2 1 
ATOM   6095 C  CE1 . PHE B 1 487 ? 15.11869 22.77327  -71.40609  1.000 20.37109  ? 445 PHE B CE1 1 
ATOM   6096 C  CE2 . PHE B 1 487 ? 13.97673 24.75495  -72.19473  1.000 14.73753  ? 445 PHE B CE2 1 
ATOM   6097 C  CZ  . PHE B 1 487 ? 14.32729 23.90560  -71.15411  1.000 14.18450  ? 445 PHE B CZ  1 
ATOM   6098 N  N   . CYS B 1 488 ? 14.69639 22.52421  -78.16734  1.000 19.48174  ? 446 CYS B N   1 
ATOM   6099 C  CA  . CYS B 1 488 ? 15.19026 22.62149  -79.53597  1.000 17.26165  ? 446 CYS B CA  1 
ATOM   6100 C  C   . CYS B 1 488 ? 15.53419 24.07219  -79.85234  1.000 24.55347  ? 446 CYS B C   1 
ATOM   6101 O  O   . CYS B 1 488 ? 14.90389 24.99863  -79.33697  1.000 15.85739  ? 446 CYS B O   1 
ATOM   6102 C  CB  . CYS B 1 488 ? 14.17302 22.05529  -80.54915  1.000 19.99133  ? 446 CYS B CB  1 
ATOM   6103 S  SG  . CYS B 1 488 ? 14.20862 20.16292  -80.54915  1.000 31.50264  ? 446 CYS B SG  1 
ATOM   6104 N  N   . GLY B 1 489 ? 16.55191 24.25253  -80.69595  1.000 21.45917  ? 447 GLY B N   1 
ATOM   6105 C  CA  . GLY B 1 489 ? 16.96777 25.58638  -81.10264  1.000 18.71896  ? 447 GLY B CA  1 
ATOM   6106 C  C   . GLY B 1 489 ? 16.03906 26.11119  -82.17347  1.000 25.01941  ? 447 GLY B C   1 
ATOM   6107 O  O   . GLY B 1 489 ? 15.68202 25.39285  -83.11396  1.000 20.77694  ? 447 GLY B O   1 
ATOM   6108 N  N   . VAL B 1 490 ? 15.62505 27.36585  -82.02343  1.000 22.57393  ? 448 VAL B N   1 
ATOM   6109 C  CA  . VAL B 1 490 ? 14.75019 28.01032  -82.98973  1.000 21.93922  ? 448 VAL B CA  1 
ATOM   6110 C  C   . VAL B 1 490 ? 15.26908 29.40948  -83.29170  1.000 22.87725  ? 448 VAL B C   1 
ATOM   6111 O  O   . VAL B 1 490 ? 15.97199 30.03680  -82.49025  1.000 22.72905  ? 448 VAL B O   1 
ATOM   6112 C  CB  . VAL B 1 490 ? 13.29828 28.07628  -82.48491  1.000 18.45309  ? 448 VAL B CB  1 
ATOM   6113 C  CG1 . VAL B 1 490 ? 12.71100 26.64000  -82.30377  1.000 17.14795  ? 448 VAL B CG1 1 
ATOM   6114 C  CG2 . VAL B 1 490 ? 13.28237 28.83575  -81.18587  1.000 16.22720  ? 448 VAL B CG2 1 
ATOM   6115 N  N   . ASN B 1 491 ? 14.92581 29.87705  -84.47654  1.000 22.87592  ? 449 ASN B N   1 
ATOM   6116 C  CA  . ASN B 1 491 ? 15.18580 31.25248  -84.88143  1.000 24.98938  ? 449 ASN B CA  1 
ATOM   6117 C  C   . ASN B 1 491 ? 13.91256 32.08696  -84.75488  1.000 25.69486  ? 449 ASN B C   1 
ATOM   6118 O  O   . ASN B 1 491 ? 13.41536 32.67258  -85.71670  1.000 36.48150  ? 449 ASN B O   1 
ATOM   6119 C  CB  . ASN B 1 491 ? 15.71735 31.28125  -86.30628  1.000 26.39660  ? 449 ASN B CB  1 
ATOM   6120 C  CG  . ASN B 1 491 ? 16.39957 32.58261  -86.62327  1.000 34.28639  ? 449 ASN B CG  1 
ATOM   6121 O  OD1 . ASN B 1 491 ? 16.80230 33.31464  -85.71706  1.000 35.13615  ? 449 ASN B OD1 1 
ATOM   6122 N  ND2 . ASN B 1 491 ? 16.50347 32.90207  -87.90756  1.000 32.25136  ? 449 ASN B ND2 1 
ATOM   6123 N  N   . SER B 1 492 ? 13.37254 32.09179  -83.53873  1.000 20.71257  ? 450 SER B N   1 
ATOM   6124 C  CA  . SER B 1 492 ? 12.19812 32.86372  -83.16720  1.000 21.54928  ? 450 SER B CA  1 
ATOM   6125 C  C   . SER B 1 492 ? 12.30701 33.13682  -81.67603  1.000 24.03784  ? 450 SER B C   1 
ATOM   6126 O  O   . SER B 1 492 ? 13.28509 32.75384  -81.02415  1.000 20.18497  ? 450 SER B O   1 
ATOM   6127 C  CB  . SER B 1 492 ? 10.89527 32.13688  -83.53431  1.000 24.70558  ? 450 SER B CB  1 
ATOM   6128 O  OG  . SER B 1 492 ? 10.83582 30.83156  -82.96513  1.000 23.45301  ? 450 SER B OG  1 
ATOM   6129 N  N   . ASP B 1 493 ? 11.29761 33.79881  -81.13433  1.000 20.87384  ? 451 ASP B N   1 
ATOM   6130 C  CA  . ASP B 1 493 ? 11.38003 34.27018  -79.76476  1.000 20.94857  ? 451 ASP B CA  1 
ATOM   6131 C  C   . ASP B 1 493 ? 11.35949 33.10816  -78.77960  1.000 21.97721  ? 451 ASP B C   1 
ATOM   6132 O  O   . ASP B 1 493 ? 10.58293 32.16635  -78.92816  1.000 20.01453  ? 451 ASP B O   1 
ATOM   6133 C  CB  . ASP B 1 493 ? 10.21044 35.20094  -79.46879  1.000 21.27373  ? 451 ASP B CB  1 
ATOM   6134 C  CG  . ASP B 1 493 ? 10.30133 36.52162  -80.23228  1.000 25.26229  ? 451 ASP B CG  1 
ATOM   6135 O  OD1 . ASP B 1 493 ? 11.38150 36.85083  -80.77300  1.000 26.79006  ? 451 ASP B OD1 1 
ATOM   6136 O  OD2 . ASP B 1 493 ? 9.26600  37.21404  -80.31710  1.000 32.80702  ? 451 ASP B OD2 1 
ATOM   6137 N  N   . THR B 1 494 ? 12.17383 33.20677  -77.73135  1.000 14.40467  ? 452 THR B N   1 
ATOM   6138 C  CA  . THR B 1 494 ? 12.18730 32.20185  -76.67802  1.000 17.32472  ? 452 THR B CA  1 
ATOM   6139 C  C   . THR B 1 494 ? 12.29728 32.92874  -75.35652  1.000 15.53069  ? 452 THR B C   1 
ATOM   6140 O  O   . THR B 1 494 ? 12.38845 34.16491  -75.30890  1.000 16.23372  ? 452 THR B O   1 
ATOM   6141 C  CB  . THR B 1 494 ? 13.37284 31.24217  -76.83015  1.000 19.42441  ? 452 THR B CB  1 
ATOM   6142 O  OG1 . THR B 1 494 ? 14.59242 32.02659  -76.81734  1.000 21.19229  ? 452 THR B OG1 1 
ATOM   6143 C  CG2 . THR B 1 494 ? 13.28774 30.49177  -78.12913  1.000 17.38565  ? 452 THR B CG2 1 
ATOM   6144 N  N   . VAL B 1 495 ? 12.38139 32.16642  -74.26623  1.000 16.47460  ? 453 VAL B N   1 
ATOM   6145 C  CA  . VAL B 1 495 ? 12.51668 32.79657  -72.95896  1.000 18.31125  ? 453 VAL B CA  1 
ATOM   6146 C  C   . VAL B 1 495 ? 13.23628 31.83729  -72.03635  1.000 16.12753  ? 453 VAL B C   1 
ATOM   6147 O  O   . VAL B 1 495 ? 13.09519 30.61207  -72.14133  1.000 16.83563  ? 453 VAL B O   1 
ATOM   6148 C  CB  . VAL B 1 495 ? 11.14169 33.21165  -72.36064  1.000 21.86562  ? 453 VAL B CB  1 
ATOM   6149 C  CG1 . VAL B 1 495 ? 10.28488 31.97025  -72.03566  1.000 12.67659  ? 453 VAL B CG1 1 
ATOM   6150 C  CG2 . VAL B 1 495 ? 11.33854 34.04265  -71.09001  1.000 15.95887  ? 453 VAL B CG2 1 
ATOM   6151 N  N   . GLY B 1 496 ? 13.99346 32.40618  -71.10667  1.000 22.77702  ? 454 GLY B N   1 
ATOM   6152 C  CA  . GLY B 1 496 ? 14.61899 31.62720  -70.06943  1.000 20.13398  ? 454 GLY B CA  1 
ATOM   6153 C  C   . GLY B 1 496 ? 13.69945 31.46855  -68.87470  1.000 24.45185  ? 454 GLY B C   1 
ATOM   6154 O  O   . GLY B 1 496 ? 12.84800 32.30682  -68.60458  1.000 21.64102  ? 454 GLY B O   1 
ATOM   6155 N  N   . TRP B 1 497 ? 13.90283 30.38300  -68.14521  1.000 21.04255  ? 455 TRP B N   1 
ATOM   6156 C  CA  . TRP B 1 497 ? 13.14014 30.11272  -66.94745  1.000 18.74642  ? 455 TRP B CA  1 
ATOM   6157 C  C   . TRP B 1 497 ? 13.90862 29.04980  -66.17515  1.000 21.41699  ? 455 TRP B C   1 
ATOM   6158 O  O   . TRP B 1 497 ? 15.07949 28.78054  -66.46669  1.000 28.06780  ? 455 TRP B O   1 
ATOM   6159 C  CB  . TRP B 1 497 ? 11.71668 29.65269  -67.30974  1.000 17.29987  ? 455 TRP B CB  1 
ATOM   6160 C  CG  . TRP B 1 497 ? 10.68325 29.95922  -66.28821  1.000 21.16190  ? 455 TRP B CG  1 
ATOM   6161 C  CD1 . TRP B 1 497 ? 10.73022 30.96348  -65.36087  1.000 22.21903  ? 455 TRP B CD1 1 
ATOM   6162 C  CD2 . TRP B 1 497 ? 9.43044  29.26167  -66.06861  1.000 19.55854  ? 455 TRP B CD2 1 
ATOM   6163 N  NE1 . TRP B 1 497 ? 9.58167  30.95015  -64.58797  1.000 19.56698  ? 455 TRP B NE1 1 
ATOM   6164 C  CE2 . TRP B 1 497 ? 8.76164  29.92932  -65.00637  1.000 17.18946  ? 455 TRP B CE2 1 
ATOM   6165 C  CE3 . TRP B 1 497 ? 8.81223  28.14242  -66.66232  1.000 23.05606  ? 455 TRP B CE3 1 
ATOM   6166 C  CZ2 . TRP B 1 497 ? 7.50244  29.51413  -64.51241  1.000 17.51446  ? 455 TRP B CZ2 1 
ATOM   6167 C  CZ3 . TRP B 1 497 ? 7.51170  27.73274  -66.17561  1.000 17.57181  ? 455 TRP B CZ3 1 
ATOM   6168 C  CH2 . TRP B 1 497 ? 6.88786  28.42617  -65.12010  1.000 19.98334  ? 455 TRP B CH2 1 
ATOM   6169 N  N   . SER B 1 498 ? 13.24253 28.43330  -65.21480  1.000 19.15423  ? 456 SER B N   1 
ATOM   6170 C  CA  . SER B 1 498 ? 13.75547 27.29051  -64.49238  1.000 19.18958  ? 456 SER B CA  1 
ATOM   6171 C  C   . SER B 1 498 ? 12.68718 26.21690  -64.57925  1.000 21.68945  ? 456 SER B C   1 
ATOM   6172 O  O   . SER B 1 498 ? 11.57909 26.42375  -64.07773  1.000 20.45935  ? 456 SER B O   1 
ATOM   6173 C  CB  . SER B 1 498 ? 14.02487 27.63201  -63.04126  1.000 18.84057  ? 456 SER B CB  1 
ATOM   6174 O  OG  . SER B 1 498 ? 14.43765 26.46511  -62.35625  1.000 14.58140  ? 456 SER B OG  1 
ATOM   6175 N  N   . TRP B 1 499 ? 13.00898 25.08864  -65.23122  1.000 20.99279  ? 457 TRP B N   1 
ATOM   6176 C  CA  . TRP B 1 499 ? 12.10911 23.93961  -65.35221  1.000 19.51891  ? 457 TRP B CA  1 
ATOM   6177 C  C   . TRP B 1 499 ? 12.71908 22.77028  -64.60382  1.000 21.16965  ? 457 TRP B C   1 
ATOM   6178 O  O   . TRP B 1 499 ? 13.30830 21.87899  -65.23058  1.000 18.57840  ? 457 TRP B O   1 
ATOM   6179 C  CB  . TRP B 1 499 ? 11.89856 23.50647  -66.80552  1.000 16.32942  ? 457 TRP B CB  1 
ATOM   6180 C  CG  . TRP B 1 499 ? 11.03804 24.39146  -67.66607  1.000 22.08374  ? 457 TRP B CG  1 
ATOM   6181 C  CD1 . TRP B 1 499 ? 9.68115  24.31615  -67.83468  1.000 19.48491  ? 457 TRP B CD1 1 
ATOM   6182 C  CD2 . TRP B 1 499 ? 11.48609 25.49427  -68.46898  1.000 21.73775  ? 457 TRP B CD2 1 
ATOM   6183 N  NE1 . TRP B 1 499 ? 9.27093  25.26958  -68.71657  1.000 20.52079  ? 457 TRP B NE1 1 
ATOM   6184 C  CE2 . TRP B 1 499 ? 10.35318 26.02161  -69.11101  1.000 16.79749  ? 457 TRP B CE2 1 
ATOM   6185 C  CE3 . TRP B 1 499 ? 12.74726 26.08702  -68.70057  1.000 20.87947  ? 457 TRP B CE3 1 
ATOM   6186 C  CZ2 . TRP B 1 499 ? 10.42194 27.12645  -69.97490  1.000 14.62668  ? 457 TRP B CZ2 1 
ATOM   6187 C  CZ3 . TRP B 1 499 ? 12.82968 27.16180  -69.57017  1.000 19.97047  ? 457 TRP B CZ3 1 
ATOM   6188 C  CH2 . TRP B 1 499 ? 11.66361 27.68192  -70.19907  1.000 21.27125  ? 457 TRP B CH2 1 
ATOM   6189 N  N   . PRO B 1 500 ? 12.61681 22.73497  -63.29956  1.000 19.68218  ? 458 PRO B N   1 
ATOM   6190 C  CA  . PRO B 1 500 ? 13.35637 21.72675  -62.53467  1.000 17.12711  ? 458 PRO B CA  1 
ATOM   6191 C  C   . PRO B 1 500 ? 12.58006 20.42457  -62.36297  1.000 20.03047  ? 458 PRO B C   1 
ATOM   6192 O  O   . PRO B 1 500 ? 11.43351 20.28559  -62.81616  1.000 17.45703  ? 458 PRO B O   1 
ATOM   6193 C  CB  . PRO B 1 500 ? 13.57626 22.42467  -61.18911  1.000 14.58768  ? 458 PRO B CB  1 
ATOM   6194 C  CG  . PRO B 1 500 ? 12.36123 23.28671  -61.03182  1.000 17.89585  ? 458 PRO B CG  1 
ATOM   6195 C  CD  . PRO B 1 500 ? 11.90665 23.67790  -62.42851  1.000 18.70647  ? 458 PRO B CD  1 
ATOM   6196 N  N   . ASP B 1 501 ? 13.19553 19.47100  -61.66506  1.000 17.92165  ? 459 ASP B N   1 
ATOM   6197 C  CA  . ASP B 1 501 ? 12.62253 18.13320  -61.56330  1.000 15.97995  ? 459 ASP B CA  1 
ATOM   6198 C  C   . ASP B 1 501 ? 11.29003 18.15077  -60.81859  1.000 18.27472  ? 459 ASP B C   1 
ATOM   6199 O  O   . ASP B 1 501 ? 10.27502 17.61633  -61.29917  1.000 20.13142  ? 459 ASP B O   1 
ATOM   6200 C  CB  . ASP B 1 501 ? 13.60318 17.21665  -60.85463  1.000 14.73051  ? 459 ASP B CB  1 
ATOM   6201 C  CG  . ASP B 1 501 ? 12.94573 15.93375  -60.41094  1.000 19.85812  ? 459 ASP B CG  1 
ATOM   6202 O  OD1 . ASP B 1 501 ? 12.68544 15.03887  -61.27340  1.000 16.11546  ? 459 ASP B OD1 1 
ATOM   6203 O  OD2 . ASP B 1 501 ? 12.65028 15.85132  -59.19560  1.000 24.16188  ? 459 ASP B OD2 1 
ATOM   6204 N  N   . GLY B 1 502 ? 11.28684 18.71282  -59.61348  1.000 19.51281  ? 460 GLY B N   1 
ATOM   6205 C  CA  . GLY B 1 502 ? 10.06491 18.99017  -58.90153  1.000 21.05350  ? 460 GLY B CA  1 
ATOM   6206 C  C   . GLY B 1 502 ? 9.59142  17.92687  -57.94084  1.000 24.26809  ? 460 GLY B C   1 
ATOM   6207 O  O   . GLY B 1 502 ? 8.56894  18.13550  -57.26667  1.000 21.25793  ? 460 GLY B O   1 
ATOM   6208 N  N   . ALA B 1 503 ? 10.27807 16.79326  -57.83999  1.000 16.41880  ? 461 ALA B N   1 
ATOM   6209 C  CA  . ALA B 1 503 ? 9.83031  15.78310  -56.88903  1.000 17.68513  ? 461 ALA B CA  1 
ATOM   6210 C  C   . ALA B 1 503 ? 10.19121 16.21299  -55.46908  1.000 14.98407  ? 461 ALA B C   1 
ATOM   6211 O  O   . ALA B 1 503 ? 11.14701 16.96676  -55.25319  1.000 17.89049  ? 461 ALA B O   1 
ATOM   6212 C  CB  . ALA B 1 503 ? 10.43292 14.40197  -57.22705  1.000 13.90540  ? 461 ALA B CB  1 
ATOM   6213 N  N   . GLU B 1 504 ? 9.42386  15.70775  -54.48862  1.000 17.02861  ? 462 GLU B N   1 
ATOM   6214 C  CA  . GLU B 1 504 ? 9.63636  16.00630  -53.07259  1.000 20.04896  ? 462 GLU B CA  1 
ATOM   6215 C  C   . GLU B 1 504 ? 10.35426 14.82858  -52.40150  1.000 24.41745  ? 462 GLU B C   1 
ATOM   6216 O  O   . GLU B 1 504 ? 9.73994  13.81364  -52.08639  1.000 20.87604  ? 462 GLU B O   1 
ATOM   6217 C  CB  . GLU B 1 504 ? 8.30477  16.29191  -52.37407  1.000 24.34688  ? 462 GLU B CB  1 
ATOM   6218 C  CG  . GLU B 1 504 ? 7.44542  17.36136  -53.05182  1.000 42.66211  ? 462 GLU B CG  1 
ATOM   6219 C  CD  . GLU B 1 504 ? 7.98659  18.78606  -52.89306  1.000 66.40221  ? 462 GLU B CD  1 
ATOM   6220 O  OE1 . GLU B 1 504 ? 8.63274  19.08923  -51.85775  1.000 66.32607  ? 462 GLU B OE1 1 
ATOM   6221 O  OE2 . GLU B 1 504 ? 7.75732  19.61196  -53.81299  1.000 65.01729  ? 462 GLU B OE2 1 
ATOM   6222 N  N   . LEU B 1 505 ? 11.64023 14.98344  -52.12828  1.000 21.65095  ? 463 LEU B N   1 
ATOM   6223 C  CA  . LEU B 1 505 ? 12.36000 13.90502  -51.47396  1.000 19.23033  ? 463 LEU B CA  1 
ATOM   6224 C  C   . LEU B 1 505 ? 12.46411 14.21628  -49.99737  1.000 20.07946  ? 463 LEU B C   1 
ATOM   6225 O  O   . LEU B 1 505 ? 12.35625 15.37396  -49.59788  1.000 25.59586  ? 463 LEU B O   1 
ATOM   6226 C  CB  . LEU B 1 505 ? 13.74938 13.73962  -52.09594  1.000 19.04702  ? 463 LEU B CB  1 
ATOM   6227 C  CG  . LEU B 1 505 ? 13.86735 12.85846  -53.33083  1.000 15.20742  ? 463 LEU B CG  1 
ATOM   6228 C  CD1 . LEU B 1 505 ? 12.94726 13.30663  -54.45931  1.000 17.11015  ? 463 LEU B CD1 1 
ATOM   6229 C  CD2 . LEU B 1 505 ? 15.31714 12.84310  -53.80060  1.000 16.30467  ? 463 LEU B CD2 1 
ATOM   6230 N  N   . PRO B 1 506 ? 12.65415 13.22122  -49.14430  1.000 19.07599  ? 464 PRO B N   1 
ATOM   6231 C  CA  . PRO B 1 506 ? 12.78395 11.78826  -49.42599  1.000 22.01482  ? 464 PRO B CA  1 
ATOM   6232 C  C   . PRO B 1 506 ? 11.45034 11.16837  -49.84993  1.000 22.69860  ? 464 PRO B C   1 
ATOM   6233 O  O   . PRO B 1 506 ? 10.37330 11.79818  -49.70606  1.000 16.84641  ? 464 PRO B O   1 
ATOM   6234 C  CB  . PRO B 1 506 ? 13.27366 11.21233  -48.09145  1.000 21.55242  ? 464 PRO B CB  1 
ATOM   6235 C  CG  . PRO B 1 506 ? 13.63723 12.39167  -47.21032  1.000 20.28231  ? 464 PRO B CG  1 
ATOM   6236 C  CD  . PRO B 1 506 ? 12.86100 13.53638  -47.72256  1.000 20.38903  ? 464 PRO B CD  1 
ATOM   6237 N  N   . PHE B 1 507 ? 11.50127 9.95193   -50.39910  1.000 18.43056  ? 465 PHE B N   1 
ATOM   6238 C  CA  . PHE B 1 507 ? 10.30517 9.16494   -50.68851  1.000 13.75842  ? 465 PHE B CA  1 
ATOM   6239 C  C   . PHE B 1 507 ? 9.97832  8.23881   -49.51829  1.000 17.60991  ? 465 PHE B C   1 
ATOM   6240 O  O   . PHE B 1 507 ? 10.75824 8.07010   -48.58246  1.000 16.81730  ? 465 PHE B O   1 
ATOM   6241 C  CB  . PHE B 1 507 ? 10.47233 8.34555   -51.97418  1.000 15.31792  ? 465 PHE B CB  1 
ATOM   6242 C  CG  . PHE B 1 507 ? 10.19190 9.11900   -53.23396  1.000 14.24330  ? 465 PHE B CG  1 
ATOM   6243 C  CD1 . PHE B 1 507 ? 9.95895  10.50633  -53.18448  1.000 16.58304  ? 465 PHE B CD1 1 
ATOM   6244 C  CD2 . PHE B 1 507 ? 10.13204 8.47046   -54.46305  1.000 14.70896  ? 465 PHE B CD2 1 
ATOM   6245 C  CE1 . PHE B 1 507 ? 9.66245  11.23464  -54.35232  1.000 16.99719  ? 465 PHE B CE1 1 
ATOM   6246 C  CE2 . PHE B 1 507 ? 9.82446  9.18647   -55.64764  1.000 15.22443  ? 465 PHE B CE2 1 
ATOM   6247 C  CZ  . PHE B 1 507 ? 9.59687  10.57903  -55.58476  1.000 23.45034  ? 465 PHE B CZ  1 
ATOM   6248 N  N   . THR B 1 508 ? 8.80043  7.61625   -49.59580  1.000 21.84637  ? 466 THR B N   1 
ATOM   6249 C  CA  . THR B 1 508 ? 8.37618  6.64049   -48.58870  1.000 20.06662  ? 466 THR B CA  1 
ATOM   6250 C  C   . THR B 1 508 ? 9.43330  5.58270   -48.32631  1.000 17.84699  ? 466 THR B C   1 
ATOM   6251 O  O   . THR B 1 508 ? 9.66855  5.20369   -47.17185  1.000 19.33761  ? 466 THR B O   1 
ATOM   6252 C  CB  . THR B 1 508 ? 7.09280  5.94484   -49.03435  1.000 25.22544  ? 466 THR B CB  1 
ATOM   6253 O  OG1 . THR B 1 508 ? 6.13161  6.93445   -49.37365  1.000 26.47410  ? 466 THR B OG1 1 
ATOM   6254 C  CG2 . THR B 1 508 ? 6.57186  5.12035   -47.91888  1.000 19.48492  ? 466 THR B CG2 1 
ATOM   6255 N  N   . ILE B 1 509 ? 10.05135 5.06535   -49.39235  1.000 18.25756  ? 467 ILE B N   1 
ATOM   6256 C  CA  . ILE B 1 509 ? 11.06388 4.00922   -49.25944  1.000 19.58041  ? 467 ILE B CA  1 
ATOM   6257 C  C   . ILE B 1 509 ? 12.26663 4.50907   -48.47037  1.000 25.38055  ? 467 ILE B C   1 
ATOM   6258 O  O   . ILE B 1 509 ? 13.02387 3.71075   -47.90573  1.000 23.82150  ? 467 ILE B O   1 
ATOM   6259 C  CB  . ILE B 1 509 ? 11.50029 3.52802   -50.66386  1.000 18.77359  ? 467 ILE B CB  1 
ATOM   6260 C  CG1 . ILE B 1 509 ? 12.16276 2.14246   -50.62599  1.000 22.67398  ? 467 ILE B CG1 1 
ATOM   6261 C  CG2 . ILE B 1 509 ? 12.47049 4.52708   -51.31703  1.000 17.34043  ? 467 ILE B CG2 1 
ATOM   6262 C  CD1 . ILE B 1 509 ? 11.27293 1.00559   -50.04674  1.000 16.92714  ? 467 ILE B CD1 1 
ATOM   6263 N  N   . ASP B 1 510 ? 12.48213 5.82539   -48.43909  1.000 20.53398  ? 468 ASP B N   1 
ATOM   6264 C  CA  . ASP B 1 510 ? 13.66824 6.40468   -47.81092  1.000 22.96630  ? 468 ASP B CA  1 
ATOM   6265 C  C   . ASP B 1 510 ? 13.51797 6.64838   -46.31415  1.000 26.34801  ? 468 ASP B C   1 
ATOM   6266 O  O   . ASP B 1 510 ? 14.49038 7.03175   -45.66127  1.000 33.25427  ? 468 ASP B O   1 
ATOM   6267 C  CB  . ASP B 1 510 ? 14.02946 7.69025   -48.54288  1.000 20.27286  ? 468 ASP B CB  1 
ATOM   6268 C  CG  . ASP B 1 510 ? 14.30951 7.42936   -50.00978  1.000 17.97196  ? 468 ASP B CG  1 
ATOM   6269 O  OD1 . ASP B 1 510 ? 15.11642 6.51283   -50.26150  1.000 20.21742  ? 468 ASP B OD1 1 
ATOM   6270 O  OD2 . ASP B 1 510 ? 13.69497 8.09328   -50.88847  1.000 17.88474  ? 468 ASP B OD2 1 
ATOM   6271 N  N   . LYS B 1 511 ? 12.33115 6.47852   -45.76271  1.000 30.00018  ? 469 LYS B N   1 
ATOM   6272 C  CA  . LYS B 1 511 ? 12.09439 6.75720   -44.34685  1.000 39.50935  ? 469 LYS B CA  1 
ATOM   6273 C  C   . LYS B 1 511 ? 12.28091 5.51928   -43.49270  1.000 42.03278  ? 469 LYS B C   1 
ATOM   6274 O  O   . LYS B 1 511 ? 13.20739 5.46442   -42.69488  1.000 62.68944  ? 469 LYS B O   1 
ATOM   6275 C  CB  . LYS B 1 511 ? 10.67251 7.30752   -44.12317  1.000 37.52537  ? 469 LYS B CB  1 
ATOM   6276 C  CG  . LYS B 1 511 ? 10.45615 8.77454   -44.47948  1.000 45.04184  ? 469 LYS B CG  1 
ATOM   6277 C  CD  . LYS B 1 511 ? 9.93697  9.02482   -45.87480  1.000 36.93702  ? 469 LYS B CD  1 
ATOM   6278 C  CE  . LYS B 1 511 ? 9.46692  10.48143  -46.06510  1.000 38.56994  ? 469 LYS B CE  1 
ATOM   6279 N  NZ  . LYS B 1 511 ? 8.00344  10.61045  -46.41193  1.000 38.42132  ? 469 LYS B NZ  1 
HETATM 6280 C  C1  . NAG C 2 .   ? 41.52772 25.58419  -55.96785  1.000 32.51550  ? 1   NAG C C1  1 
HETATM 6281 C  C2  . NAG C 2 .   ? 42.08086 26.07514  -57.30016  1.000 33.27434  ? 1   NAG C C2  1 
HETATM 6282 C  C3  . NAG C 2 .   ? 41.94917 24.98195  -58.37357  1.000 31.98071  ? 1   NAG C C3  1 
HETATM 6283 C  C4  . NAG C 2 .   ? 42.53762 23.65173  -57.91191  1.000 39.87302  ? 1   NAG C C4  1 
HETATM 6284 C  C5  . NAG C 2 .   ? 41.93786 23.27978  -56.54359  1.000 33.71877  ? 1   NAG C C5  1 
HETATM 6285 C  C6  . NAG C 2 .   ? 42.53444 22.01189  -55.95432  1.000 44.49993  ? 1   NAG C C6  1 
HETATM 6286 C  C7  . NAG C 2 .   ? 41.98097 28.51089  -57.74133  1.000 36.72725  ? 1   NAG C C7  1 
HETATM 6287 C  C8  . NAG C 2 .   ? 41.16460 29.64686  -58.34957  1.000 22.21353  ? 1   NAG C C8  1 
HETATM 6288 N  N2  . NAG C 2 .   ? 41.44600 27.27924  -57.78716  1.000 24.44588  ? 1   NAG C N2  1 
HETATM 6289 O  O3  . NAG C 2 .   ? 42.55337 25.44890  -59.55237  1.000 34.62288  ? 1   NAG C O3  1 
HETATM 6290 O  O4  . NAG C 2 .   ? 42.28237 22.67483  -58.91581  1.000 36.91151  ? 1   NAG C O4  1 
HETATM 6291 O  O5  . NAG C 2 .   ? 42.14504 24.34934  -55.63365  1.000 36.94427  ? 1   NAG C O5  1 
HETATM 6292 O  O6  . NAG C 2 .   ? 43.91973 22.17665  -55.68231  1.000 48.56376  ? 1   NAG C O6  1 
HETATM 6293 O  O7  . NAG C 2 .   ? 43.05663 28.69640  -57.19870  1.000 39.41361  ? 1   NAG C O7  1 
HETATM 6294 C  C1  . NAG C 2 .   ? 43.57226 22.03473  -59.17957  1.000 40.79290  ? 2   NAG C C1  1 
HETATM 6295 C  C2  . NAG C 2 .   ? 43.26333 20.66932  -59.82142  1.000 37.01908  ? 2   NAG C C2  1 
HETATM 6296 C  C3  . NAG C 2 .   ? 44.53456 19.97176  -60.34613  1.000 42.24769  ? 2   NAG C C3  1 
HETATM 6297 C  C4  . NAG C 2 .   ? 45.41097 20.89872  -61.17772  1.000 34.04751  ? 2   NAG C C4  1 
HETATM 6298 C  C5  . NAG C 2 .   ? 45.65390 22.14698  -60.32784  1.000 35.90446  ? 2   NAG C C5  1 
HETATM 6299 C  C6  . NAG C 2 .   ? 46.54409 23.15187  -61.00799  1.000 39.69199  ? 2   NAG C C6  1 
HETATM 6300 C  C7  . NAG C 2 .   ? 41.45519 19.26581  -58.89999  1.000 34.39938  ? 2   NAG C C7  1 
HETATM 6301 C  C8  . NAG C 2 .   ? 40.99618 18.50220  -57.68233  1.000 35.41810  ? 2   NAG C C8  1 
HETATM 6302 N  N2  . NAG C 2 .   ? 42.64175 19.87640  -58.79226  1.000 37.91764  ? 2   NAG C N2  1 
HETATM 6303 O  O3  . NAG C 2 .   ? 44.11721 18.84265  -61.08203  1.000 37.71989  ? 2   NAG C O3  1 
HETATM 6304 O  O4  . NAG C 2 .   ? 46.60201 20.21292  -61.55914  1.000 45.38295  ? 2   NAG C O4  1 
HETATM 6305 O  O5  . NAG C 2 .   ? 44.40906 22.78337  -60.05058  1.000 35.83054  ? 2   NAG C O5  1 
HETATM 6306 O  O6  . NAG C 2 .   ? 45.84708 24.37706  -61.16130  1.000 48.91232  ? 2   NAG C O6  1 
HETATM 6307 O  O7  . NAG C 2 .   ? 40.80152 19.32754  -59.92296  1.000 34.41471  ? 2   NAG C O7  1 
HETATM 6308 CA CA  . CA  D 3 .   ? 3.69887  21.69720  -28.79977  1.000 29.68072  ? 500 CA  A CA  1 
HETATM 6309 CA CA  . CA  E 3 .   ? 19.96487 14.65045  -38.75944  1.000 19.42481  ? 501 CA  A CA  1 
HETATM 6310 C  C1  . NAG F 4 .   ? 41.31184 37.77135  1.07261    1.000 72.22268  ? 502 NAG A C1  1 
HETATM 6311 C  C2  . NAG F 4 .   ? 39.90529 37.63247  0.44147    1.000 83.86115  ? 502 NAG A C2  1 
HETATM 6312 C  C3  . NAG F 4 .   ? 38.96090 36.84257  1.37087    1.000 80.81502  ? 502 NAG A C3  1 
HETATM 6313 C  C4  . NAG F 4 .   ? 39.56915 35.51764  1.82918    1.000 86.67468  ? 502 NAG A C4  1 
HETATM 6314 C  C5  . NAG F 4 .   ? 40.97116 35.76033  2.40474    1.000 83.83889  ? 502 NAG A C5  1 
HETATM 6315 C  C6  . NAG F 4 .   ? 41.61246 34.43680  2.79266    1.000 80.43990  ? 502 NAG A C6  1 
HETATM 6316 C  C7  . NAG F 4 .   ? 38.88929 39.20405  -1.15528   1.000 80.18340  ? 502 NAG A C7  1 
HETATM 6317 C  C8  . NAG F 4 .   ? 38.26878 40.57411  -1.34970   1.000 68.96474  ? 502 NAG A C8  1 
HETATM 6318 N  N2  . NAG F 4 .   ? 39.30425 38.90179  0.09575    1.000 83.44986  ? 502 NAG A N2  1 
HETATM 6319 O  O3  . NAG F 4 .   ? 37.75333 36.61386  0.69842    1.000 75.46385  ? 502 NAG A O3  1 
HETATM 6320 O  O4  . NAG F 4 .   ? 38.69079 34.90565  2.76481    1.000 85.30085  ? 502 NAG A O4  1 
HETATM 6321 O  O5  . NAG F 4 .   ? 41.76741 36.47586  1.46157    1.000 81.77141  ? 502 NAG A O5  1 
HETATM 6322 O  O6  . NAG F 4 .   ? 42.94407 34.55213  3.22468    1.000 81.28734  ? 502 NAG A O6  1 
HETATM 6323 O  O7  . NAG F 4 .   ? 39.00931 38.42042  -2.08822   1.000 73.90972  ? 502 NAG A O7  1 
HETATM 6324 C  C1  . NAG G 4 .   ? 24.76756 28.39452  -5.25909   1.000 69.65321  ? 503 NAG A C1  1 
HETATM 6325 C  C2  . NAG G 4 .   ? 23.75842 28.60354  -4.11584   1.000 76.69863  ? 503 NAG A C2  1 
HETATM 6326 C  C3  . NAG G 4 .   ? 24.19234 29.82236  -3.26699   1.000 85.14021  ? 503 NAG A C3  1 
HETATM 6327 C  C4  . NAG G 4 .   ? 25.65716 29.71144  -2.81281   1.000 91.27999  ? 503 NAG A C4  1 
HETATM 6328 C  C5  . NAG G 4 .   ? 26.52061 29.48735  -4.06571   1.000 83.16868  ? 503 NAG A C5  1 
HETATM 6329 C  C6  . NAG G 4 .   ? 28.02319 29.43116  -3.83870   1.000 81.11327  ? 503 NAG A C6  1 
HETATM 6330 C  C7  . NAG G 4 .   ? 21.52048 27.73039  -4.79456   1.000 74.53115  ? 503 NAG A C7  1 
HETATM 6331 C  C8  . NAG G 4 .   ? 20.16955 28.10780  -5.36721   1.000 66.68998  ? 503 NAG A C8  1 
HETATM 6332 N  N2  . NAG G 4 .   ? 22.41612 28.73812  -4.65108   1.000 77.67706  ? 503 NAG A N2  1 
HETATM 6333 O  O3  . NAG G 4 .   ? 23.32887 29.98200  -2.16905   1.000 82.08254  ? 503 NAG A O3  1 
HETATM 6334 O  O4  . NAG G 4 .   ? 26.00172 30.89397  -2.11270   1.000 91.68807  ? 503 NAG A O4  1 
HETATM 6335 O  O5  . NAG G 4 .   ? 26.07231 28.30539  -4.71383   1.000 71.41484  ? 503 NAG A O5  1 
HETATM 6336 O  O6  . NAG G 4 .   ? 28.48266 28.11979  -3.60131   1.000 85.99965  ? 503 NAG A O6  1 
HETATM 6337 O  O7  . NAG G 4 .   ? 21.76806 26.56867  -4.50443   1.000 69.69123  ? 503 NAG A O7  1 
HETATM 6338 CA CA  . CA  H 3 .   ? 34.08817 35.23421  -76.09199  1.000 39.01956  ? 500 CA  B CA  1 
HETATM 6339 CA CA  . CA  I 3 .   ? 36.84811 17.80184  -65.99667  1.000 22.78889  ? 501 CA  B CA  1 
HETATM 6340 C  C1  . NAG J 4 .   ? 8.94856  2.78027   -106.15317 1.000 91.55291  ? 502 NAG B C1  1 
HETATM 6341 C  C2  . NAG J 4 .   ? 9.58641  3.98852   -105.42772 1.000 92.13440  ? 502 NAG B C2  1 
HETATM 6342 C  C3  . NAG J 4 .   ? 10.60697 4.69180   -106.34252 1.000 91.65856  ? 502 NAG B C3  1 
HETATM 6343 C  C4  . NAG J 4 .   ? 11.61571 3.72006   -106.95331 1.000 93.87358  ? 502 NAG B C4  1 
HETATM 6344 C  C5  . NAG J 4 .   ? 10.85952 2.55907   -107.61673 1.000 99.13127  ? 502 NAG B C5  1 
HETATM 6345 C  C6  . NAG J 4 .   ? 11.78648 1.50949   -108.20903 1.000 94.52584  ? 502 NAG B C6  1 
HETATM 6346 C  C7  . NAG J 4 .   ? 8.46464  5.41479   -103.69521 1.000 87.71257  ? 502 NAG B C7  1 
HETATM 6347 C  C8  . NAG J 4 .   ? 7.39412  6.47431   -103.49834 1.000 63.92429  ? 502 NAG B C8  1 
HETATM 6348 N  N2  . NAG J 4 .   ? 8.62416  4.97086   -104.96538 1.000 93.24307  ? 502 NAG B N2  1 
HETATM 6349 O  O3  . NAG J 4 .   ? 11.26541 5.68772   -105.60441 1.000 87.34118  ? 502 NAG B O3  1 
HETATM 6350 O  O4  . NAG J 4 .   ? 12.43632 4.42892   -107.86410 1.000 88.82237  ? 502 NAG B O4  1 
HETATM 6351 O  O5  . NAG J 4 .   ? 9.96946  1.95365   -106.68386 1.000 93.14426  ? 502 NAG B O5  1 
HETATM 6352 O  O6  . NAG J 4 .   ? 12.80040 1.12901   -107.30697 1.000 88.72315  ? 502 NAG B O6  1 
HETATM 6353 O  O7  . NAG J 4 .   ? 9.12968  4.99390   -102.75532 1.000 79.27855  ? 502 NAG B O7  1 
HETATM 6354 C  C1  . NAG K 4 .   ? 22.39915 16.56473  -99.66320  1.000 69.21639  ? 503 NAG B C1  1 
HETATM 6355 C  C2  . NAG K 4 .   ? 22.39017 17.62729  -100.78237 1.000 70.57374  ? 503 NAG B C2  1 
HETATM 6356 C  C3  . NAG K 4 .   ? 21.02560 17.63434  -101.48899 1.000 77.81666  ? 503 NAG B C3  1 
HETATM 6357 C  C4  . NAG K 4 .   ? 20.63606 16.23117  -101.96359 1.000 87.74758  ? 503 NAG B C4  1 
HETATM 6358 C  C5  . NAG K 4 .   ? 20.71084 15.27749  -100.75423 1.000 83.60047  ? 503 NAG B C5  1 
HETATM 6359 C  C6  . NAG K 4 .   ? 20.29026 13.83165  -101.00147 1.000 81.85146  ? 503 NAG B C6  1 
HETATM 6360 C  C7  . NAG K 4 .   ? 23.96423 19.45066  -100.24806 1.000 76.72116  ? 503 NAG B C7  1 
HETATM 6361 C  C8  . NAG K 4 .   ? 25.07969 18.64819  -100.88413 1.000 63.38241  ? 503 NAG B C8  1 
HETATM 6362 N  N2  . NAG K 4 .   ? 22.72162 18.91661  -100.24547 1.000 70.32405  ? 503 NAG B N2  1 
HETATM 6363 O  O3  . NAG K 4 .   ? 21.04616 18.54752  -102.55278 1.000 78.86053  ? 503 NAG B O3  1 
HETATM 6364 O  O4  . NAG K 4 .   ? 19.34519 16.31486  -102.54417 1.000 72.79222  ? 503 NAG B O4  1 
HETATM 6365 O  O5  . NAG K 4 .   ? 22.03472 15.31689  -100.23145 1.000 73.71854  ? 503 NAG B O5  1 
HETATM 6366 O  O6  . NAG K 4 .   ? 21.37965 13.01353  -101.38119 1.000 77.98901  ? 503 NAG B O6  1 
HETATM 6367 O  O7  . NAG K 4 .   ? 24.19668 20.54746  -99.77431  1.000 87.58505  ? 503 NAG B O7  1 
HETATM 6368 C  C1  . NAG L 4 .   ? 20.96494 -1.88662  -49.31311  1.000 72.95780  ? 504 NAG B C1  1 
HETATM 6369 C  C2  . NAG L 4 .   ? 20.24633 -1.99825  -47.95087  1.000 79.25629  ? 504 NAG B C2  1 
HETATM 6370 C  C3  . NAG L 4 .   ? 21.23186 -2.34300  -46.82967  1.000 77.55446  ? 504 NAG B C3  1 
HETATM 6371 C  C4  . NAG L 4 .   ? 22.08256 -3.56071  -47.15206  1.000 83.54527  ? 504 NAG B C4  1 
HETATM 6372 C  C5  . NAG L 4 .   ? 22.69905 -3.37802  -48.53907  1.000 85.06984  ? 504 NAG B C5  1 
HETATM 6373 C  C6  . NAG L 4 .   ? 23.47226 -4.61621  -48.94224  1.000 78.69151  ? 504 NAG B C6  1 
HETATM 6374 C  C7  . NAG L 4 .   ? 18.21306 -0.57233  -47.64028  1.000 72.04787  ? 504 NAG B C7  1 
HETATM 6375 C  C8  . NAG L 4 .   ? 17.78522 0.79933   -47.17949  1.000 73.66794  ? 504 NAG B C8  1 
HETATM 6376 N  N2  . NAG L 4 .   ? 19.54589 -0.78586  -47.58656  1.000 81.95787  ? 504 NAG B N2  1 
HETATM 6377 O  O3  . NAG L 4 .   ? 20.51268 -2.53760  -45.63595  1.000 75.74195  ? 504 NAG B O3  1 
HETATM 6378 O  O4  . NAG L 4 .   ? 23.06797 -3.71250  -46.13327  1.000 66.93481  ? 504 NAG B O4  1 
HETATM 6379 O  O5  . NAG L 4 .   ? 21.68509 -3.09334  -49.50050  1.000 74.96697  ? 504 NAG B O5  1 
HETATM 6380 O  O6  . NAG L 4 .   ? 24.18266 -5.10965  -47.82496  1.000 85.30604  ? 504 NAG B O6  1 
HETATM 6381 O  O7  . NAG L 4 .   ? 17.38833 -1.39083  -48.03177  1.000 67.00158  ? 504 NAG B O7  1 
HETATM 6382 O  O   . HOH M 5 .   ? 33.10465 42.48909  -28.12397  1.000 28.74865  ? 601 HOH A O   1 
HETATM 6383 O  O   . HOH M 5 .   ? 26.04365 34.39243  -54.13167  1.000 35.44113  ? 602 HOH A O   1 
HETATM 6384 O  O   . HOH M 5 .   ? 34.18455 2.65551   -26.89673  1.000 45.82725  ? 603 HOH A O   1 
HETATM 6385 O  O   . HOH M 5 .   ? 32.67263 30.34871  -20.88196  1.000 22.10766  ? 604 HOH A O   1 
HETATM 6386 O  O   . HOH M 5 .   ? 16.74226 39.16911  -44.84595  1.000 31.36419  ? 605 HOH A O   1 
HETATM 6387 O  O   . HOH M 5 .   ? 38.37112 7.79402   -22.82928  1.000 36.10648  ? 606 HOH A O   1 
HETATM 6388 O  O   . HOH M 5 .   ? 26.54062 25.42541  -56.07948  1.000 36.98696  ? 607 HOH A O   1 
HETATM 6389 O  O   . HOH M 5 .   ? 30.67967 32.08353  -7.79734   1.000 31.23264  ? 608 HOH A O   1 
HETATM 6390 O  O   . HOH M 5 .   ? 17.07964 8.27671   -41.76818  1.000 29.79615  ? 609 HOH A O   1 
HETATM 6391 O  O   . HOH M 5 .   ? 9.91515  21.33933  -40.32256  1.000 20.09723  ? 610 HOH A O   1 
HETATM 6392 O  O   . HOH M 5 .   ? 11.52451 7.37973   -33.97729  1.000 36.82293  ? 611 HOH A O   1 
HETATM 6393 O  O   . HOH M 5 .   ? 44.70223 14.19896  -44.01337  1.000 41.38857  ? 612 HOH A O   1 
HETATM 6394 O  O   . HOH M 5 .   ? 49.51163 29.91822  -55.88655  1.000 40.12041  ? 613 HOH A O   1 
HETATM 6395 O  O   . HOH M 5 .   ? 39.17357 42.10671  -24.57551  1.000 38.87853  ? 614 HOH A O   1 
HETATM 6396 O  O   . HOH M 5 .   ? 29.00305 16.65351  -37.69592  1.000 32.92627  ? 615 HOH A O   1 
HETATM 6397 O  O   . HOH M 5 .   ? 23.03769 35.43839  -15.44504  1.000 20.06819  ? 616 HOH A O   1 
HETATM 6398 O  O   . HOH M 5 .   ? 1.04991  14.38152  -30.23921  1.000 27.36298  ? 617 HOH A O   1 
HETATM 6399 O  O   . HOH M 5 .   ? 2.82551  13.48343  -26.70083  1.000 32.30157  ? 618 HOH A O   1 
HETATM 6400 O  O   . HOH M 5 .   ? 42.84081 14.92865  -42.33511  1.000 22.95243  ? 619 HOH A O   1 
HETATM 6401 O  O   . HOH M 5 .   ? 45.93351 34.66979  -16.19971  1.000 58.65851  ? 620 HOH A O   1 
HETATM 6402 O  O   . HOH M 5 .   ? 30.42925 6.50967   -12.90713  1.000 37.13185  ? 621 HOH A O   1 
HETATM 6403 O  O   . HOH M 5 .   ? 40.80674 39.46159  -46.02951  1.000 23.97379  ? 622 HOH A O   1 
HETATM 6404 O  O   . HOH M 5 .   ? 33.93696 40.89761  -25.95910  1.000 33.46445  ? 623 HOH A O   1 
HETATM 6405 O  O   . HOH M 5 .   ? 40.53052 9.84558   -34.31027  1.000 13.89343  ? 624 HOH A O   1 
HETATM 6406 O  O   . HOH M 5 .   ? 5.99959  24.76421  -20.50092  1.000 34.47489  ? 625 HOH A O   1 
HETATM 6407 O  O   . HOH M 5 .   ? 20.08547 32.49358  -7.69638   1.000 49.60234  ? 626 HOH A O   1 
HETATM 6408 O  O   . HOH M 5 .   ? 28.99549 38.41043  -33.61856  1.000 15.60752  ? 627 HOH A O   1 
HETATM 6409 O  O   . HOH M 5 .   ? 28.76990 5.26263   -26.59224  1.000 21.67753  ? 628 HOH A O   1 
HETATM 6410 O  O   . HOH M 5 .   ? 26.65939 32.50483  -8.40304   1.000 27.67759  ? 629 HOH A O   1 
HETATM 6411 O  O   . HOH M 5 .   ? 40.78792 33.38756  -24.89543  1.000 34.65786  ? 630 HOH A O   1 
HETATM 6412 O  O   . HOH M 5 .   ? 19.64144 25.19848  -33.65239  1.000 14.55777  ? 631 HOH A O   1 
HETATM 6413 O  O   . HOH M 5 .   ? 15.08671 29.47716  -48.47220  1.000 37.60409  ? 632 HOH A O   1 
HETATM 6414 O  O   . HOH M 5 .   ? 17.53288 38.24336  -11.47548  1.000 37.86110  ? 633 HOH A O   1 
HETATM 6415 O  O   . HOH M 5 .   ? 21.94727 25.76381  -36.87245  1.000 16.84954  ? 634 HOH A O   1 
HETATM 6416 O  O   . HOH M 5 .   ? 38.43597 45.11290  -28.36908  1.000 29.40691  ? 635 HOH A O   1 
HETATM 6417 O  O   . HOH M 5 .   ? 9.86165  27.35415  -40.39461  1.000 30.81519  ? 636 HOH A O   1 
HETATM 6418 O  O   . HOH M 5 .   ? 7.08296  35.42587  -35.75941  1.000 36.41331  ? 637 HOH A O   1 
HETATM 6419 O  O   . HOH M 5 .   ? 18.53932 3.96541   -39.05624  1.000 28.55255  ? 638 HOH A O   1 
HETATM 6420 O  O   . HOH M 5 .   ? 8.14995  16.65117  -44.86775  1.000 33.81062  ? 639 HOH A O   1 
HETATM 6421 O  O   . HOH M 5 .   ? 27.69159 24.71076  -25.92269  1.000 16.99218  ? 640 HOH A O   1 
HETATM 6422 O  O   . HOH M 5 .   ? 29.70976 31.54939  -21.70611  1.000 19.67049  ? 641 HOH A O   1 
HETATM 6423 O  O   . HOH M 5 .   ? 19.53703 15.85494  -35.11376  1.000 16.43955  ? 642 HOH A O   1 
HETATM 6424 O  O   . HOH M 5 .   ? 0.12272  17.33221  -27.55364  1.000 27.40073  ? 643 HOH A O   1 
HETATM 6425 O  O   . HOH M 5 .   ? 24.48903 43.54484  -49.09716  1.000 39.84544  ? 644 HOH A O   1 
HETATM 6426 O  O   . HOH M 5 .   ? 37.60036 28.38637  -47.70491  1.000 17.84375  ? 645 HOH A O   1 
HETATM 6427 O  O   . HOH M 5 .   ? 17.61642 15.03335  -48.23725  1.000 23.90814  ? 646 HOH A O   1 
HETATM 6428 O  O   . HOH M 5 .   ? 21.74978 30.49323  -6.47047   1.000 59.63929  ? 647 HOH A O   1 
HETATM 6429 O  O   . HOH M 5 .   ? 26.96028 4.02048   -18.99626  1.000 35.70380  ? 648 HOH A O   1 
HETATM 6430 O  O   . HOH M 5 .   ? 37.880   44.299    -52.224    1.000 44.12903  ? 649 HOH A O   1 
HETATM 6431 O  O   . HOH M 5 .   ? 23.15705 38.33789  -46.81816  1.000 25.74069  ? 650 HOH A O   1 
HETATM 6432 O  O   . HOH M 5 .   ? 17.43877 2.64243   -28.23967  1.000 32.64628  ? 651 HOH A O   1 
HETATM 6433 O  O   . HOH M 5 .   ? 13.15011 10.89139  -25.61272  1.000 29.53178  ? 652 HOH A O   1 
HETATM 6434 O  O   . HOH M 5 .   ? 0.31803  15.85795  -33.47378  1.000 34.86123  ? 653 HOH A O   1 
HETATM 6435 O  O   . HOH M 5 .   ? 35.38543 6.60195   -20.05884  1.000 38.67914  ? 654 HOH A O   1 
HETATM 6436 O  O   . HOH M 5 .   ? 33.33779 9.20151   -38.88164  1.000 35.74663  ? 655 HOH A O   1 
HETATM 6437 O  O   . HOH M 5 .   ? 9.22732  42.10072  -37.40841  1.000 26.18808  ? 656 HOH A O   1 
HETATM 6438 O  O   . HOH M 5 .   ? 32.94420 35.59241  -37.53982  1.000 30.67465  ? 657 HOH A O   1 
HETATM 6439 O  O   . HOH M 5 .   ? 42.87159 44.06475  -48.91636  1.000 36.08178  ? 658 HOH A O   1 
HETATM 6440 O  O   . HOH M 5 .   ? 43.80487 6.24776   -31.29011  1.000 27.10935  ? 659 HOH A O   1 
HETATM 6441 O  O   . HOH M 5 .   ? 14.76408 7.40954   -28.00703  1.000 47.85378  ? 660 HOH A O   1 
HETATM 6442 O  O   . HOH M 5 .   ? 32.36581 16.99650  -8.29758   1.000 58.12287  ? 661 HOH A O   1 
HETATM 6443 O  O   . HOH M 5 .   ? 37.36565 25.69600  -53.97647  1.000 32.68128  ? 662 HOH A O   1 
HETATM 6444 O  O   . HOH M 5 .   ? 24.261   40.282    -22.331    1.000 22.64438  ? 663 HOH A O   1 
HETATM 6445 O  O   . HOH M 5 .   ? 38.76841 9.17578   -42.45202  1.000 32.76202  ? 664 HOH A O   1 
HETATM 6446 O  O   . HOH M 5 .   ? 28.45241 1.76170   -36.66251  1.000 23.23826  ? 665 HOH A O   1 
HETATM 6447 O  O   . HOH M 5 .   ? 10.11602 39.29763  -25.65338  1.000 23.64418  ? 666 HOH A O   1 
HETATM 6448 O  O   . HOH M 5 .   ? 43.52354 12.92378  -16.72842  1.000 35.76956  ? 667 HOH A O   1 
HETATM 6449 O  O   . HOH M 5 .   ? 41.76511 34.03969  -58.49618  1.000 43.79821  ? 668 HOH A O   1 
HETATM 6450 O  O   . HOH M 5 .   ? 46.30015 36.47652  -34.67523  1.000 26.19795  ? 669 HOH A O   1 
HETATM 6451 O  O   . HOH M 5 .   ? 40.93600 8.23369   -24.81250  1.000 29.08711  ? 670 HOH A O   1 
HETATM 6452 O  O   . HOH M 5 .   ? 36.23335 37.70713  -7.59439   1.000 46.44249  ? 671 HOH A O   1 
HETATM 6453 O  O   . HOH M 5 .   ? 33.76560 37.59076  -34.80377  1.000 21.15195  ? 672 HOH A O   1 
HETATM 6454 O  O   . HOH M 5 .   ? -0.26236 20.32724  -33.70420  1.000 25.45702  ? 673 HOH A O   1 
HETATM 6455 O  O   . HOH M 5 .   ? 14.40518 27.87574  -15.53456  1.000 32.99749  ? 674 HOH A O   1 
HETATM 6456 O  O   . HOH M 5 .   ? 33.36882 36.25665  -40.30430  1.000 21.37267  ? 675 HOH A O   1 
HETATM 6457 O  O   . HOH M 5 .   ? 47.91893 13.64252  -18.07774  1.000 46.84481  ? 676 HOH A O   1 
HETATM 6458 O  O   . HOH M 5 .   ? 27.22395 30.40560  -11.99015  1.000 23.53502  ? 677 HOH A O   1 
HETATM 6459 O  O   . HOH M 5 .   ? 42.72273 14.25361  -39.76640  1.000 22.06059  ? 678 HOH A O   1 
HETATM 6460 O  O   . HOH M 5 .   ? 12.75728 14.40450  -24.65514  1.000 22.99689  ? 679 HOH A O   1 
HETATM 6461 O  O   . HOH M 5 .   ? 31.70926 37.88600  -33.02952  1.000 19.53512  ? 680 HOH A O   1 
HETATM 6462 O  O   . HOH M 5 .   ? 45.58625 19.94004  -30.76404  1.000 15.44203  ? 681 HOH A O   1 
HETATM 6463 O  O   . HOH M 5 .   ? 31.96282 19.21486  -9.56236   1.000 42.32132  ? 682 HOH A O   1 
HETATM 6464 O  O   . HOH M 5 .   ? 41.796   51.861    -48.533    1.000 31.08588  ? 683 HOH A O   1 
HETATM 6465 O  O   . HOH M 5 .   ? 23.93460 20.29631  -32.17590  1.000 14.69111  ? 684 HOH A O   1 
HETATM 6466 O  O   . HOH M 5 .   ? 32.98170 26.67268  -12.37209  1.000 23.41091  ? 685 HOH A O   1 
HETATM 6467 O  O   . HOH M 5 .   ? 39.806   45.448    -32.714    1.000 20.51154  ? 686 HOH A O   1 
HETATM 6468 O  O   . HOH M 5 .   ? 40.17748 43.73908  -30.19117  1.000 29.58227  ? 687 HOH A O   1 
HETATM 6469 O  O   . HOH M 5 .   ? 48.59539 28.22826  -25.57023  1.000 28.28504  ? 688 HOH A O   1 
HETATM 6470 O  O   . HOH M 5 .   ? 23.88883 42.99278  -15.80789  1.000 30.65392  ? 689 HOH A O   1 
HETATM 6471 O  O   . HOH M 5 .   ? 43.54210 23.49730  -26.23023  1.000 21.47082  ? 690 HOH A O   1 
HETATM 6472 O  O   . HOH M 5 .   ? 26.14273 26.78297  -23.72168  1.000 19.79577  ? 691 HOH A O   1 
HETATM 6473 O  O   . HOH M 5 .   ? 22.69578 35.43894  -44.62382  1.000 19.46393  ? 692 HOH A O   1 
HETATM 6474 O  O   . HOH M 5 .   ? 25.13825 10.42521  -42.18601  1.000 38.40371  ? 693 HOH A O   1 
HETATM 6475 O  O   . HOH M 5 .   ? 38.45524 23.14187  -10.17605  1.000 40.47927  ? 694 HOH A O   1 
HETATM 6476 O  O   . HOH M 5 .   ? 47.870   30.960    -26.787    1.000 33.05205  ? 695 HOH A O   1 
HETATM 6477 O  O   . HOH M 5 .   ? 43.00540 30.38498  -23.54789  1.000 32.51246  ? 696 HOH A O   1 
HETATM 6478 O  O   . HOH M 5 .   ? 18.08838 37.05731  -19.12604  1.000 35.30903  ? 697 HOH A O   1 
HETATM 6479 O  O   . HOH M 5 .   ? 14.67487 41.47868  -30.35032  1.000 17.71996  ? 698 HOH A O   1 
HETATM 6480 O  O   . HOH M 5 .   ? 44.18289 28.14939  -25.43973  1.000 20.72232  ? 699 HOH A O   1 
HETATM 6481 O  O   . HOH M 5 .   ? 28.21926 26.57524  -20.72171  1.000 17.62633  ? 700 HOH A O   1 
HETATM 6482 O  O   . HOH M 5 .   ? 15.79031 21.21425  -31.36584  1.000 15.37040  ? 701 HOH A O   1 
HETATM 6483 O  O   . HOH M 5 .   ? 39.360   42.901    -36.599    1.000 23.86403  ? 702 HOH A O   1 
HETATM 6484 O  O   . HOH M 5 .   ? 15.21074 25.55480  -17.32764  1.000 31.31362  ? 703 HOH A O   1 
HETATM 6485 O  O   . HOH M 5 .   ? 33.991   46.224    -46.627    1.000 17.13685  ? 704 HOH A O   1 
HETATM 6486 O  O   . HOH M 5 .   ? 0.47889  21.32414  -36.74361  1.000 29.78711  ? 705 HOH A O   1 
HETATM 6487 O  O   . HOH M 5 .   ? 28.98945 28.42133  -27.59864  1.000 15.76445  ? 706 HOH A O   1 
HETATM 6488 O  O   . HOH M 5 .   ? 17.05666 22.86773  -33.35370  1.000 20.35660  ? 707 HOH A O   1 
HETATM 6489 O  O   . HOH M 5 .   ? 29.31440 39.80472  -43.30963  1.000 13.28921  ? 708 HOH A O   1 
HETATM 6490 O  O   . HOH M 5 .   ? 48.27738 33.96439  -15.85919  1.000 48.93321  ? 709 HOH A O   1 
HETATM 6491 O  O   . HOH M 5 .   ? 10.18633 14.82618  -32.82011  1.000 19.10706  ? 710 HOH A O   1 
HETATM 6492 O  O   . HOH M 5 .   ? 2.47083  29.52172  -24.42210  1.000 39.72568  ? 711 HOH A O   1 
HETATM 6493 O  O   . HOH M 5 .   ? 24.04322 39.90279  -52.88450  1.000 36.92902  ? 712 HOH A O   1 
HETATM 6494 O  O   . HOH M 5 .   ? 31.68637 29.00910  -18.85638  1.000 21.33558  ? 713 HOH A O   1 
HETATM 6495 O  O   . HOH M 5 .   ? 44.66365 21.07881  -37.04335  1.000 16.35795  ? 714 HOH A O   1 
HETATM 6496 O  O   . HOH M 5 .   ? 42.54159 18.73655  -11.49074  1.000 31.56463  ? 715 HOH A O   1 
HETATM 6497 O  O   . HOH M 5 .   ? 35.20494 35.50304  -42.34413  1.000 18.72054  ? 716 HOH A O   1 
HETATM 6498 O  O   . HOH M 5 .   ? 3.61766  21.28461  -41.44460  1.000 38.32878  ? 717 HOH A O   1 
HETATM 6499 O  O   . HOH M 5 .   ? 30.19235 34.80973  -32.67902  1.000 20.65391  ? 718 HOH A O   1 
HETATM 6500 O  O   . HOH M 5 .   ? 10.23342 26.26574  -44.84683  1.000 50.30659  ? 719 HOH A O   1 
HETATM 6501 O  O   . HOH M 5 .   ? 44.89968 29.35845  -13.68010  1.000 34.54451  ? 720 HOH A O   1 
HETATM 6502 O  O   . HOH M 5 .   ? 19.78551 16.47055  -15.16487  1.000 42.26763  ? 721 HOH A O   1 
HETATM 6503 O  O   . HOH M 5 .   ? 38.19354 23.86427  -13.99390  1.000 23.12133  ? 722 HOH A O   1 
HETATM 6504 O  O   . HOH M 5 .   ? 22.21138 21.02654  -43.04370  1.000 16.42742  ? 723 HOH A O   1 
HETATM 6505 O  O   . HOH M 5 .   ? 38.31577 34.30613  -49.90841  1.000 11.61468  ? 724 HOH A O   1 
HETATM 6506 O  O   . HOH M 5 .   ? 34.51521 44.31628  -29.12744  1.000 26.86243  ? 725 HOH A O   1 
HETATM 6507 O  O   . HOH M 5 .   ? 9.45928  48.25538  -24.13980  1.000 27.26854  ? 726 HOH A O   1 
HETATM 6508 O  O   . HOH M 5 .   ? 17.63081 23.56189  -38.08758  1.000 17.20361  ? 727 HOH A O   1 
HETATM 6509 O  O   . HOH M 5 .   ? 45.91371 31.58851  -12.91179  1.000 45.18444  ? 728 HOH A O   1 
HETATM 6510 O  O   . HOH M 5 .   ? 42.80364 32.12565  -19.03829  1.000 23.42262  ? 729 HOH A O   1 
HETATM 6511 O  O   . HOH M 5 .   ? 29.514   0.758     -31.949    1.000 47.31514  ? 730 HOH A O   1 
HETATM 6512 O  O   . HOH M 5 .   ? 3.20869  10.54290  -30.30532  1.000 30.59300  ? 731 HOH A O   1 
HETATM 6513 O  O   . HOH M 5 .   ? 7.36812  7.90456   -31.62172  1.000 36.84222  ? 732 HOH A O   1 
HETATM 6514 O  O   . HOH M 5 .   ? 24.47511 28.75029  -45.54898  1.000 25.44537  ? 733 HOH A O   1 
HETATM 6515 O  O   . HOH M 5 .   ? 20.88508 14.73053  -12.11931  1.000 37.76880  ? 734 HOH A O   1 
HETATM 6516 O  O   . HOH M 5 .   ? 29.31353 22.46704  -42.32284  1.000 25.59900  ? 735 HOH A O   1 
HETATM 6517 O  O   . HOH M 5 .   ? 3.84322  23.65552  -37.08355  1.000 38.42761  ? 736 HOH A O   1 
HETATM 6518 O  O   . HOH M 5 .   ? 38.93789 9.11985   -20.70327  1.000 35.45741  ? 737 HOH A O   1 
HETATM 6519 O  O   . HOH M 5 .   ? 30.84479 16.13817  -33.09000  1.000 16.58312  ? 738 HOH A O   1 
HETATM 6520 O  O   . HOH M 5 .   ? 15.62037 43.02186  -20.06035  1.000 24.69211  ? 739 HOH A O   1 
HETATM 6521 O  O   . HOH M 5 .   ? 13.53550 23.19844  -16.63308  1.000 31.53698  ? 740 HOH A O   1 
HETATM 6522 O  O   . HOH M 5 .   ? 27.70823 11.05267  -42.61603  1.000 40.31949  ? 741 HOH A O   1 
HETATM 6523 O  O   . HOH M 5 .   ? 48.282   22.116    -48.713    1.000 44.91810  ? 742 HOH A O   1 
HETATM 6524 O  O   . HOH M 5 .   ? 38.06322 24.02097  -44.37255  1.000 35.67749  ? 743 HOH A O   1 
HETATM 6525 O  O   . HOH M 5 .   ? 43.38853 27.84511  -22.24017  1.000 19.53088  ? 744 HOH A O   1 
HETATM 6526 O  O   . HOH M 5 .   ? 32.50912 44.28108  -36.81990  1.000 17.77396  ? 745 HOH A O   1 
HETATM 6527 O  O   . HOH M 5 .   ? 45.04810 38.41408  -52.41951  1.000 36.68236  ? 746 HOH A O   1 
HETATM 6528 O  O   . HOH M 5 .   ? 51.631   21.043    -47.625    1.000 44.64834  ? 747 HOH A O   1 
HETATM 6529 O  O   . HOH M 5 .   ? 15.24284 17.62398  -48.12848  1.000 35.94610  ? 748 HOH A O   1 
HETATM 6530 O  O   . HOH M 5 .   ? 30.37560 31.69270  -18.83741  1.000 27.35020  ? 749 HOH A O   1 
HETATM 6531 O  O   . HOH M 5 .   ? 24.56658 31.16544  -8.63370   1.000 33.67177  ? 750 HOH A O   1 
HETATM 6532 O  O   . HOH M 5 .   ? 43.80569 11.24991  -41.61613  1.000 23.04124  ? 751 HOH A O   1 
HETATM 6533 O  O   . HOH M 5 .   ? 7.01137  26.98165  -38.93722  1.000 32.05586  ? 752 HOH A O   1 
HETATM 6534 O  O   . HOH M 5 .   ? 34.59514 22.78668  -42.07924  1.000 54.65645  ? 753 HOH A O   1 
HETATM 6535 O  O   . HOH M 5 .   ? 42.14349 38.77696  -28.94479  1.000 24.89686  ? 754 HOH A O   1 
HETATM 6536 O  O   . HOH M 5 .   ? 19.99906 14.16099  -15.91783  1.000 38.25439  ? 755 HOH A O   1 
HETATM 6537 O  O   . HOH M 5 .   ? 50.66035 7.09149   -31.94114  1.000 38.53925  ? 756 HOH A O   1 
HETATM 6538 O  O   . HOH M 5 .   ? 29.28610 33.88543  -17.87186  1.000 18.29761  ? 757 HOH A O   1 
HETATM 6539 O  O   . HOH M 5 .   ? 8.34179  40.34473  -33.76059  1.000 27.67322  ? 758 HOH A O   1 
HETATM 6540 O  O   . HOH M 5 .   ? 15.49210 6.67777   -37.16568  1.000 28.26109  ? 759 HOH A O   1 
HETATM 6541 O  O   . HOH M 5 .   ? 14.26090 9.69628   -21.80000  1.000 35.46330  ? 760 HOH A O   1 
HETATM 6542 O  O   . HOH M 5 .   ? 10.68289 46.00974  -22.71155  1.000 25.15087  ? 761 HOH A O   1 
HETATM 6543 O  O   . HOH M 5 .   ? 46.253   30.204    -37.794    1.000 27.13802  ? 762 HOH A O   1 
HETATM 6544 O  O   . HOH M 5 .   ? 23.84741 39.31722  -49.49855  1.000 38.52016  ? 763 HOH A O   1 
HETATM 6545 O  O   . HOH M 5 .   ? 16.10949 42.92968  -42.49100  1.000 26.81470  ? 764 HOH A O   1 
HETATM 6546 O  O   . HOH M 5 .   ? 18.03489 41.96040  -19.26004  1.000 34.30609  ? 765 HOH A O   1 
HETATM 6547 O  O   . HOH M 5 .   ? 9.16144  37.36761  -35.72808  1.000 20.41488  ? 766 HOH A O   1 
HETATM 6548 O  O   . HOH M 5 .   ? 38.71404 25.68906  -10.96292  1.000 38.66335  ? 767 HOH A O   1 
HETATM 6549 O  O   . HOH M 5 .   ? 0.73095  17.41806  -35.48148  1.000 33.03724  ? 768 HOH A O   1 
HETATM 6550 O  O   . HOH M 5 .   ? 21.49387 23.64774  -26.36538  1.000 19.81286  ? 769 HOH A O   1 
HETATM 6551 O  O   . HOH M 5 .   ? 29.49999 1.45981   -27.59834  1.000 40.09037  ? 770 HOH A O   1 
HETATM 6552 O  O   . HOH M 5 .   ? 25.32998 17.82925  -10.27812  1.000 31.36878  ? 771 HOH A O   1 
HETATM 6553 O  O   . HOH M 5 .   ? 7.41743  9.04407   -28.81820  1.000 35.65307  ? 772 HOH A O   1 
HETATM 6554 O  O   . HOH M 5 .   ? 37.84347 26.95380  -41.05102  1.000 23.34780  ? 773 HOH A O   1 
HETATM 6555 O  O   . HOH M 5 .   ? 12.19115 38.74395  -15.47863  1.000 37.60705  ? 774 HOH A O   1 
HETATM 6556 O  O   . HOH M 5 .   ? 18.97013 20.96705  -15.71830  1.000 35.38131  ? 775 HOH A O   1 
HETATM 6557 O  O   . HOH M 5 .   ? 6.44218  22.84935  -18.49073  1.000 27.92615  ? 776 HOH A O   1 
HETATM 6558 O  O   . HOH M 5 .   ? 5.08187  25.26824  -38.42776  1.000 39.10445  ? 777 HOH A O   1 
HETATM 6559 O  O   . HOH M 5 .   ? 38.20192 7.57325   -40.38737  1.000 32.34200  ? 778 HOH A O   1 
HETATM 6560 O  O   . HOH M 5 .   ? 41.59354 41.76890  -29.48501  1.000 27.21037  ? 779 HOH A O   1 
HETATM 6561 O  O   . HOH M 5 .   ? 22.70522 23.83519  -46.69992  1.000 24.60199  ? 780 HOH A O   1 
HETATM 6562 O  O   . HOH M 5 .   ? 46.15691 35.55985  -53.55160  1.000 20.79232  ? 781 HOH A O   1 
HETATM 6563 O  O   . HOH M 5 .   ? 22.89932 -1.41322  -24.96043  1.000 21.84284  ? 782 HOH A O   1 
HETATM 6564 O  O   . HOH M 5 .   ? 11.90145 18.51430  -32.45383  1.000 19.43723  ? 783 HOH A O   1 
HETATM 6565 O  O   . HOH M 5 .   ? 14.39235 18.72961  -32.63117  1.000 17.54633  ? 784 HOH A O   1 
HETATM 6566 O  O   . HOH M 5 .   ? 40.84484 18.16530  -8.99813   1.000 41.62334  ? 785 HOH A O   1 
HETATM 6567 O  O   . HOH M 5 .   ? 34.86166 21.07525  -37.10461  1.000 35.92028  ? 786 HOH A O   1 
HETATM 6568 O  O   . HOH M 5 .   ? 40.21086 6.45186   -39.47788  1.000 29.58845  ? 787 HOH A O   1 
HETATM 6569 O  O   . HOH M 5 .   ? 50.09019 21.64736  -16.94488  1.000 32.58245  ? 788 HOH A O   1 
HETATM 6570 O  O   . HOH M 5 .   ? 16.83243 42.99051  -30.30590  1.000 17.43656  ? 789 HOH A O   1 
HETATM 6571 O  O   . HOH M 5 .   ? 47.02365 22.53639  -29.87224  1.000 21.52767  ? 790 HOH A O   1 
HETATM 6572 O  O   . HOH M 5 .   ? 27.87526 7.27694   -14.97098  1.000 42.11865  ? 791 HOH A O   1 
HETATM 6573 O  O   . HOH M 5 .   ? 11.95360 45.78709  -42.25662  1.000 23.41275  ? 792 HOH A O   1 
HETATM 6574 O  O   . HOH M 5 .   ? 14.72805 36.96324  -16.09507  1.000 42.83527  ? 793 HOH A O   1 
HETATM 6575 O  O   . HOH M 5 .   ? 35.23159 44.61572  -36.88392  1.000 14.54402  ? 794 HOH A O   1 
HETATM 6576 O  O   . HOH M 5 .   ? 21.30961 12.73263  -14.05651  1.000 31.62897  ? 795 HOH A O   1 
HETATM 6577 O  O   . HOH M 5 .   ? 26.28271 29.82099  -48.87169  1.000 21.78235  ? 796 HOH A O   1 
HETATM 6578 O  O   . HOH M 5 .   ? 18.00386 7.88545   -20.14834  1.000 21.01918  ? 797 HOH A O   1 
HETATM 6579 O  O   . HOH M 5 .   ? 29.32805 27.40091  -18.41502  1.000 20.60270  ? 798 HOH A O   1 
HETATM 6580 O  O   . HOH M 5 .   ? 15.93179 24.58562  -13.46885  1.000 39.08737  ? 799 HOH A O   1 
HETATM 6581 O  O   . HOH M 5 .   ? 27.39140 39.09460  -39.39356  1.000 15.92645  ? 800 HOH A O   1 
HETATM 6582 O  O   . HOH M 5 .   ? 31.31017 40.07188  -57.87888  1.000 48.16800  ? 801 HOH A O   1 
HETATM 6583 O  O   . HOH M 5 .   ? 42.90339 12.15999  -20.35793  1.000 33.64948  ? 802 HOH A O   1 
HETATM 6584 O  O   . HOH M 5 .   ? 23.76663 30.78382  -55.00422  1.000 37.68743  ? 803 HOH A O   1 
HETATM 6585 O  O   . HOH M 5 .   ? 24.64198 30.00858  -11.15231  1.000 22.10414  ? 804 HOH A O   1 
HETATM 6586 O  O   . HOH M 5 .   ? 26.89496 24.50094  -45.30618  1.000 28.54344  ? 805 HOH A O   1 
HETATM 6587 O  O   . HOH M 5 .   ? 7.57339  40.55341  -29.73737  1.000 36.41867  ? 806 HOH A O   1 
HETATM 6588 O  O   . HOH M 5 .   ? 32.13126 4.27134   -19.02622  1.000 35.91457  ? 807 HOH A O   1 
HETATM 6589 O  O   . HOH M 5 .   ? 25.80526 37.65190  -52.77857  1.000 16.64720  ? 808 HOH A O   1 
HETATM 6590 O  O   . HOH M 5 .   ? 46.60658 17.38294  -31.40652  1.000 15.43466  ? 809 HOH A O   1 
HETATM 6591 O  O   . HOH M 5 .   ? 6.63882  22.66533  -41.63032  1.000 25.75951  ? 810 HOH A O   1 
HETATM 6592 O  O   . HOH M 5 .   ? 14.39521 36.30350  -46.95882  1.000 26.79094  ? 811 HOH A O   1 
HETATM 6593 O  O   . HOH M 5 .   ? 49.72820 31.02655  -19.00732  1.000 38.37671  ? 812 HOH A O   1 
HETATM 6594 O  O   . HOH M 5 .   ? 48.28038 5.63525   -28.77582  1.000 26.33187  ? 813 HOH A O   1 
HETATM 6595 O  O   . HOH M 5 .   ? 9.48998  36.01347  -28.54529  1.000 35.00449  ? 814 HOH A O   1 
HETATM 6596 O  O   . HOH M 5 .   ? 39.01907 22.70996  -16.32879  1.000 30.82037  ? 815 HOH A O   1 
HETATM 6597 O  O   . HOH M 5 .   ? 10.04978 24.49564  -41.47945  1.000 27.27894  ? 816 HOH A O   1 
HETATM 6598 O  O   . HOH M 5 .   ? 5.18603  9.50550   -31.57018  1.000 30.44843  ? 817 HOH A O   1 
HETATM 6599 O  O   . HOH M 5 .   ? 30.78439 15.16444  -30.51969  1.000 17.69744  ? 818 HOH A O   1 
HETATM 6600 O  O   . HOH M 5 .   ? 22.01374 19.65736  -9.31632   1.000 45.11125  ? 819 HOH A O   1 
HETATM 6601 O  O   . HOH M 5 .   ? 11.41249 35.02103  -43.71581  1.000 27.51558  ? 820 HOH A O   1 
HETATM 6602 O  O   . HOH M 5 .   ? 29.94010 17.06306  -29.03290  1.000 19.72898  ? 821 HOH A O   1 
HETATM 6603 O  O   . HOH M 5 .   ? 19.49091 24.26893  -36.17310  1.000 16.24750  ? 822 HOH A O   1 
HETATM 6604 O  O   . HOH M 5 .   ? 3.91778  29.22842  -22.22895  1.000 36.50401  ? 823 HOH A O   1 
HETATM 6605 O  O   . HOH M 5 .   ? 39.77968 43.53551  -53.84686  1.000 37.66289  ? 824 HOH A O   1 
HETATM 6606 O  O   . HOH M 5 .   ? 41.81020 39.36501  -54.26299  1.000 22.25166  ? 825 HOH A O   1 
HETATM 6607 O  O   . HOH M 5 .   ? 9.04846  32.02198  -42.05640  1.000 46.36401  ? 826 HOH A O   1 
HETATM 6608 O  O   . HOH M 5 .   ? 11.59376 24.62367  -46.67639  1.000 25.22672  ? 827 HOH A O   1 
HETATM 6609 O  O   . HOH M 5 .   ? 35.84056 27.00936  -44.65874  1.000 33.43698  ? 828 HOH A O   1 
HETATM 6610 O  O   . HOH M 5 .   ? 47.36418 25.85736  -16.09316  1.000 28.75788  ? 829 HOH A O   1 
HETATM 6611 O  O   . HOH M 5 .   ? 35.21667 25.24336  -49.33588  1.000 33.85662  ? 830 HOH A O   1 
HETATM 6612 O  O   . HOH M 5 .   ? 38.98812 16.16809  -43.75406  1.000 26.92007  ? 831 HOH A O   1 
HETATM 6613 O  O   . HOH M 5 .   ? 7.99283  12.49247  -43.85682  1.000 28.20522  ? 832 HOH A O   1 
HETATM 6614 O  O   . HOH M 5 .   ? 48.198   7.306     -36.357    1.000 31.64506  ? 833 HOH A O   1 
HETATM 6615 O  O   . HOH M 5 .   ? 37.78906 15.39002  -8.94323   1.000 51.04281  ? 834 HOH A O   1 
HETATM 6616 O  O   . HOH M 5 .   ? 23.37608 8.21605   -42.30756  1.000 37.61049  ? 835 HOH A O   1 
HETATM 6617 O  O   . HOH M 5 .   ? 30.74426 33.94702  -59.04861  1.000 44.06248  ? 836 HOH A O   1 
HETATM 6618 O  O   . HOH M 5 .   ? 16.78593 15.76182  -17.90119  1.000 37.60133  ? 837 HOH A O   1 
HETATM 6619 O  O   . HOH M 5 .   ? 38.86729 36.76645  -21.11827  1.000 32.01368  ? 838 HOH A O   1 
HETATM 6620 O  O   . HOH M 5 .   ? 7.43549  11.86794  -37.80635  1.000 38.45070  ? 839 HOH A O   1 
HETATM 6621 O  O   . HOH M 5 .   ? 33.80296 24.77800  -44.37582  1.000 35.52985  ? 840 HOH A O   1 
HETATM 6622 O  O   . HOH M 5 .   ? 17.87369 9.85157   -43.82257  1.000 17.39267  ? 841 HOH A O   1 
HETATM 6623 O  O   . HOH M 5 .   ? 28.18867 19.56824  -41.63348  1.000 31.30547  ? 842 HOH A O   1 
HETATM 6624 O  O   . HOH M 5 .   ? 27.45199 27.39205  -48.72309  1.000 25.68210  ? 843 HOH A O   1 
HETATM 6625 O  O   . HOH M 5 .   ? 7.81379  41.82473  -27.03711  1.000 29.05363  ? 844 HOH A O   1 
HETATM 6626 O  O   . HOH M 5 .   ? 4.395    34.018    -33.174    1.000 30.68982  ? 845 HOH A O   1 
HETATM 6627 O  O   . HOH M 5 .   ? 22.76212 36.11488  -50.70879  1.000 40.30379  ? 846 HOH A O   1 
HETATM 6628 O  O   . HOH M 5 .   ? 44.15325 8.44950   -40.64618  1.000 24.66476  ? 847 HOH A O   1 
HETATM 6629 O  O   . HOH M 5 .   ? 41.25519 40.54363  -26.76586  1.000 26.72911  ? 848 HOH A O   1 
HETATM 6630 O  O   . HOH M 5 .   ? 36.86263 7.93125   -15.22799  1.000 30.62662  ? 849 HOH A O   1 
HETATM 6631 O  O   . HOH M 5 .   ? 35.38775 13.68313  -9.86880   1.000 43.10837  ? 850 HOH A O   1 
HETATM 6632 O  O   . HOH M 5 .   ? 10.29099 9.30888   -39.76884  1.000 27.22374  ? 851 HOH A O   1 
HETATM 6633 O  O   . HOH M 5 .   ? 33.23147 5.59476   -40.74270  1.000 28.88167  ? 852 HOH A O   1 
HETATM 6634 O  O   . HOH M 5 .   ? 24.92218 1.59762   -37.72106  1.000 24.21180  ? 853 HOH A O   1 
HETATM 6635 O  O   . HOH M 5 .   ? 15.54248 4.08181   -30.47092  1.000 37.73599  ? 854 HOH A O   1 
HETATM 6636 O  O   . HOH M 5 .   ? 40.63570 13.77004  -43.76838  1.000 27.15942  ? 855 HOH A O   1 
HETATM 6637 O  O   . HOH M 5 .   ? 34.99013 22.42431  -57.25849  1.000 24.74875  ? 856 HOH A O   1 
HETATM 6638 O  O   . HOH M 5 .   ? 19.62496 39.74512  -8.73472   1.000 47.20561  ? 857 HOH A O   1 
HETATM 6639 O  O   . HOH M 5 .   ? 18.16418 18.36186  -48.83176  1.000 38.98774  ? 858 HOH A O   1 
HETATM 6640 O  O   . HOH M 5 .   ? 15.47736 4.22478   -35.90592  1.000 34.27567  ? 859 HOH A O   1 
HETATM 6641 O  O   . HOH M 5 .   ? 10.72045 31.05346  -20.37532  1.000 31.94169  ? 860 HOH A O   1 
HETATM 6642 O  O   . HOH M 5 .   ? 25.541   0.907     -26.996    1.000 40.35347  ? 861 HOH A O   1 
HETATM 6643 O  O   . HOH M 5 .   ? 0.59653  15.81619  -37.87643  1.000 46.83180  ? 862 HOH A O   1 
HETATM 6644 O  O   . HOH M 5 .   ? 20.51688 8.67399   -14.33528  1.000 38.46140  ? 863 HOH A O   1 
HETATM 6645 O  O   . HOH M 5 .   ? 7.90832  26.20771  -18.51046  1.000 39.97714  ? 864 HOH A O   1 
HETATM 6646 O  O   . HOH M 5 .   ? 0.17861  23.81173  -35.57202  1.000 30.16161  ? 865 HOH A O   1 
HETATM 6647 O  O   . HOH M 5 .   ? 41.02080 34.44047  -17.77579  1.000 37.06688  ? 866 HOH A O   1 
HETATM 6648 O  O   . HOH M 5 .   ? 28.71724 2.09311   -29.76449  1.000 42.75474  ? 867 HOH A O   1 
HETATM 6649 O  O   . HOH M 5 .   ? 1.03906  26.11684  -33.79907  1.000 24.53758  ? 868 HOH A O   1 
HETATM 6650 O  O   . HOH M 5 .   ? 35.65907 41.34631  -52.95431  1.000 19.56061  ? 869 HOH A O   1 
HETATM 6651 O  O   . HOH M 5 .   ? 38.70238 8.92379   -17.05359  1.000 42.27130  ? 870 HOH A O   1 
HETATM 6652 O  O   . HOH M 5 .   ? 47.955   6.446     -33.753    1.000 33.26043  ? 871 HOH A O   1 
HETATM 6653 O  O   . HOH M 5 .   ? -0.50120 26.26443  -29.75070  1.000 35.00865  ? 872 HOH A O   1 
HETATM 6654 O  O   . HOH M 5 .   ? 40.93022 42.51625  -50.89885  1.000 29.78624  ? 873 HOH A O   1 
HETATM 6655 O  O   . HOH M 5 .   ? 26.23617 3.77524   -27.78124  1.000 31.46907  ? 874 HOH A O   1 
HETATM 6656 O  O   . HOH M 5 .   ? 5.20429  11.56178  -26.07248  1.000 36.75227  ? 875 HOH A O   1 
HETATM 6657 O  O   . HOH M 5 .   ? 14.46981 13.56963  -16.86915  1.000 55.80212  ? 876 HOH A O   1 
HETATM 6658 O  O   . HOH M 5 .   ? 36.88174 6.38117   -17.21408  1.000 47.96708  ? 877 HOH A O   1 
HETATM 6659 O  O   . HOH M 5 .   ? 49.790   18.201    -16.536    1.000 44.98883  ? 878 HOH A O   1 
HETATM 6660 O  O   . HOH M 5 .   ? 12.22034 37.33169  -41.75978  1.000 34.48347  ? 879 HOH A O   1 
HETATM 6661 O  O   . HOH M 5 .   ? 35.86500 21.26471  -8.11168   1.000 42.61827  ? 880 HOH A O   1 
HETATM 6662 O  O   . HOH M 5 .   ? 7.71231  40.76923  -22.05893  1.000 39.17646  ? 881 HOH A O   1 
HETATM 6663 O  O   . HOH M 5 .   ? 18.62788 19.87184  -13.41009  1.000 43.93989  ? 882 HOH A O   1 
HETATM 6664 O  O   . HOH M 5 .   ? 47.00712 8.01388   -40.85948  1.000 36.06908  ? 883 HOH A O   1 
HETATM 6665 O  O   . HOH M 5 .   ? 27.25107 33.07529  -56.69654  1.000 30.29471  ? 884 HOH A O   1 
HETATM 6666 O  O   . HOH M 5 .   ? 48.448   18.869    -46.226    1.000 43.70506  ? 885 HOH A O   1 
HETATM 6667 O  O   . HOH M 5 .   ? 27.839   43.972    -54.975    1.000 44.11502  ? 886 HOH A O   1 
HETATM 6668 O  O   . HOH M 5 .   ? 31.66812 7.95861   -41.60631  1.000 33.48900  ? 887 HOH A O   1 
HETATM 6669 O  O   . HOH M 5 .   ? 41.46178 35.98668  -20.74334  1.000 43.32721  ? 888 HOH A O   1 
HETATM 6670 O  O   . HOH M 5 .   ? 6.74783  31.71712  -40.74203  1.000 52.12009  ? 889 HOH A O   1 
HETATM 6671 O  O   . HOH M 5 .   ? 14.08872 11.59480  -19.12753  1.000 52.84153  ? 890 HOH A O   1 
HETATM 6672 O  O   . HOH M 5 .   ? 41.77175 37.06186  -59.30606  1.000 44.38871  ? 891 HOH A O   1 
HETATM 6673 O  O   . HOH M 5 .   ? 22.84064 19.68638  -45.85125  1.000 45.97285  ? 892 HOH A O   1 
HETATM 6674 O  O   . HOH M 5 .   ? 44.71722 24.70946  -54.25637  1.000 51.80234  ? 893 HOH A O   1 
HETATM 6675 O  O   . HOH M 5 .   ? 45.14654 39.66420  -30.34131  1.000 37.45143  ? 894 HOH A O   1 
HETATM 6676 O  O   . HOH M 5 .   ? 43.78437 32.06666  -21.62220  1.000 43.67124  ? 895 HOH A O   1 
HETATM 6677 O  O   . HOH M 5 .   ? 7.69251  39.54958  -25.69491  1.000 37.15465  ? 896 HOH A O   1 
HETATM 6678 O  O   . HOH M 5 .   ? 21.87053 15.22423  -9.38282   1.000 56.60413  ? 897 HOH A O   1 
HETATM 6679 O  O   . HOH M 5 .   ? 1.24658  25.55951  -28.31031  1.000 30.42855  ? 898 HOH A O   1 
HETATM 6680 O  O   . HOH M 5 .   ? 28.096   1.565     -24.757    1.000 54.11296  ? 899 HOH A O   1 
HETATM 6681 O  O   . HOH M 5 .   ? 13.58224 41.90269  -43.12044  1.000 37.56915  ? 900 HOH A O   1 
HETATM 6682 O  O   . HOH M 5 .   ? 13.69010 26.38280  -13.44691  1.000 34.33099  ? 901 HOH A O   1 
HETATM 6683 O  O   . HOH M 5 .   ? 45.30464 11.26379  -17.84414  1.000 56.03680  ? 902 HOH A O   1 
HETATM 6684 O  O   . HOH M 5 .   ? 29.112   1.754     -22.452    1.000 45.76460  ? 903 HOH A O   1 
HETATM 6685 O  O   . HOH M 5 .   ? 22.53493 32.82588  -8.20935   1.000 35.98371  ? 904 HOH A O   1 
HETATM 6686 O  O   . HOH M 5 .   ? 32.90050 12.89530  -40.05090  1.000 37.01731  ? 905 HOH A O   1 
HETATM 6687 O  O   . HOH M 5 .   ? 5.82491  9.59357   -36.10678  1.000 55.51337  ? 906 HOH A O   1 
HETATM 6688 O  O   . HOH M 5 .   ? 11.87711 39.76534  -41.47231  1.000 46.56364  ? 907 HOH A O   1 
HETATM 6689 O  O   . HOH M 5 .   ? 13.52612 39.87159  -44.23079  1.000 43.21506  ? 908 HOH A O   1 
HETATM 6690 O  O   . HOH M 5 .   ? 9.22163  29.66192  -42.16692  1.000 37.93838  ? 909 HOH A O   1 
HETATM 6691 O  O   . HOH M 5 .   ? 3.66135  31.89728  -23.78404  1.000 42.49645  ? 910 HOH A O   1 
HETATM 6692 O  O   . HOH M 5 .   ? 5.95414  39.19443  -23.77171  1.000 48.64328  ? 911 HOH A O   1 
HETATM 6693 O  O   . HOH M 5 .   ? 36.75642 25.70246  -47.12979  1.000 42.15318  ? 912 HOH A O   1 
HETATM 6694 O  O   . HOH M 5 .   ? 29.30847 24.09561  -46.22884  1.000 46.20874  ? 913 HOH A O   1 
HETATM 6695 O  O   . HOH M 5 .   ? 14.64434 38.69436  -45.94393  1.000 49.26078  ? 914 HOH A O   1 
HETATM 6696 O  O   . HOH M 5 .   ? 20.21341 6.81736   -43.75420  1.000 45.12250  ? 915 HOH A O   1 
HETATM 6697 O  O   . HOH M 5 .   ? 6.55499  34.67399  -22.19872  1.000 45.61794  ? 916 HOH A O   1 
HETATM 6698 O  O   . HOH M 5 .   ? 16.06927 4.61008   -39.79726  1.000 37.39007  ? 917 HOH A O   1 
HETATM 6699 O  O   . HOH M 5 .   ? 41.85160 41.92293  -53.04119  1.000 27.06450  ? 918 HOH A O   1 
HETATM 6700 O  O   . HOH M 5 .   ? 49.829   17.177    -44.775    1.000 39.40557  ? 919 HOH A O   1 
HETATM 6701 O  O   . HOH M 5 .   ? 2.22561  22.42458  -39.50178  1.000 35.22485  ? 920 HOH A O   1 
HETATM 6702 O  O   . HOH M 5 .   ? 36.91088 9.67122   -43.95204  1.000 42.61337  ? 921 HOH A O   1 
HETATM 6703 O  O   . HOH M 5 .   ? 44.37020 42.38295  -29.63312  1.000 44.65272  ? 922 HOH A O   1 
HETATM 6704 O  O   . HOH M 5 .   ? 40.85483 8.06423   -43.78982  1.000 37.52001  ? 923 HOH A O   1 
HETATM 6705 O  O   . HOH M 5 .   ? 16.88410 18.04346  -17.05345  1.000 45.18360  ? 924 HOH A O   1 
HETATM 6706 O  O   . HOH M 5 .   ? 34.78918 35.11245  -35.78767  1.000 29.46235  ? 925 HOH A O   1 
HETATM 6707 O  O   . HOH M 5 .   ? 46.147   10.295    -19.761    1.000 48.87827  ? 926 HOH A O   1 
HETATM 6708 O  O   . HOH M 5 .   ? 20.37374 10.67081  -13.15678  1.000 36.08812  ? 927 HOH A O   1 
HETATM 6709 O  O   . HOH M 5 .   ? 40.49751 45.25144  -55.71258  1.000 44.64241  ? 928 HOH A O   1 
HETATM 6710 O  O   . HOH M 5 .   ? 42.038   9.003     -22.707    1.000 36.62498  ? 929 HOH A O   1 
HETATM 6711 O  O   . HOH M 5 .   ? 42.89860 38.83387  -56.53185  1.000 38.20998  ? 930 HOH A O   1 
HETATM 6712 O  O   . HOH M 5 .   ? 42.41713 6.68335   -41.92085  1.000 36.13033  ? 931 HOH A O   1 
HETATM 6713 O  O   . HOH M 5 .   ? 44.84751 20.02538  -10.76842  1.000 36.85317  ? 932 HOH A O   1 
HETATM 6714 O  O   . HOH M 5 .   ? 5.47134  29.49660  -42.13324  1.000 49.54373  ? 933 HOH A O   1 
HETATM 6715 O  O   . HOH M 5 .   ? 23.263   47.035    -52.388    1.000 47.45911  ? 934 HOH A O   1 
HETATM 6716 O  O   . HOH M 5 .   ? 25.67411 26.50316  -46.72090  1.000 25.89541  ? 935 HOH A O   1 
HETATM 6717 O  O   . HOH M 5 .   ? 45.48224 38.04685  -55.16864  1.000 41.56466  ? 936 HOH A O   1 
HETATM 6718 O  O   . HOH M 5 .   ? 44.46860 39.00980  -27.48621  1.000 29.40681  ? 937 HOH A O   1 
HETATM 6719 O  O   . HOH M 5 .   ? 8.27441  28.17243  -44.80055  1.000 45.79114  ? 938 HOH A O   1 
HETATM 6720 O  O   . HOH M 5 .   ? 28.16023 4.69905   -16.76588  1.000 42.79161  ? 939 HOH A O   1 
HETATM 6721 O  O   . HOH M 5 .   ? 4.22045  27.24105  -20.25519  1.000 43.86877  ? 940 HOH A O   1 
HETATM 6722 O  O   . HOH M 5 .   ? 40.77348 10.50486  -20.73113  1.000 42.52030  ? 941 HOH A O   1 
HETATM 6723 O  O   . HOH M 5 .   ? 5.24432  36.54363  -23.25383  1.000 42.34948  ? 942 HOH A O   1 
HETATM 6724 O  O   . HOH M 5 .   ? 3.55523  8.95790   -36.56174  1.000 62.16623  ? 943 HOH A O   1 
HETATM 6725 O  O   . HOH M 5 .   ? 3.823    32.744    -36.046    1.000 39.83532  ? 944 HOH A O   1 
HETATM 6726 O  O   . HOH M 5 .   ? 5.48502  9.45474   -27.09984  1.000 39.80594  ? 945 HOH A O   1 
HETATM 6727 O  O   . HOH M 5 .   ? 3.59215  26.29574  -40.26099  1.000 37.72301  ? 946 HOH A O   1 
HETATM 6728 O  O   . HOH M 5 .   ? 2.488    34.439    -34.590    1.000 56.24220  ? 947 HOH A O   1 
HETATM 6729 O  O   . HOH M 5 .   ? 41.62167 42.21947  -59.44817  1.000 51.19104  ? 948 HOH A O   1 
HETATM 6730 O  O   . HOH M 5 .   ? 6.47107  26.95336  -43.34155  1.000 53.22366  ? 949 HOH A O   1 
HETATM 6731 O  O   . HOH M 5 .   ? 43.36742 15.95546  -10.64106  1.000 47.05311  ? 950 HOH A O   1 
HETATM 6732 O  O   . HOH M 5 .   ? 28.65429 13.18696  -5.05167   1.000 56.83807  ? 951 HOH A O   1 
HETATM 6733 O  O   . HOH M 5 .   ? 46.18852 15.86289  -10.69466  1.000 53.17073  ? 952 HOH A O   1 
HETATM 6734 O  O   . HOH M 5 .   ? 43.39478 43.23349  -54.73400  1.000 45.88038  ? 953 HOH A O   1 
HETATM 6735 O  O   . HOH M 5 .   ? 5.07039  6.42993   -37.20121  1.000 61.89647  ? 954 HOH A O   1 
HETATM 6736 O  O   . HOH M 5 .   ? 44.47768 42.87514  -24.57322  1.000 59.16231  ? 955 HOH A O   1 
HETATM 6737 O  O   . HOH M 5 .   ? 43.32634 44.35802  -26.20660  1.000 50.03668  ? 956 HOH A O   1 
HETATM 6738 O  O   . HOH M 5 .   ? 27.30339 15.12325  -4.15394   1.000 57.33060  ? 957 HOH A O   1 
HETATM 6739 O  O   . HOH N 5 .   ? 30.75677 -4.36034  -62.67156  1.000 20.53519  ? 601 HOH B O   1 
HETATM 6740 O  O   . HOH N 5 .   ? 15.03419 25.79253  -93.38755  1.000 38.11737  ? 602 HOH B O   1 
HETATM 6741 O  O   . HOH N 5 .   ? 41.00993 36.90250  -71.56016  1.000 23.19071  ? 603 HOH B O   1 
HETATM 6742 O  O   . HOH N 5 .   ? 28.80713 -8.57061  -60.80720  1.000 45.25017  ? 604 HOH B O   1 
HETATM 6743 O  O   . HOH N 5 .   ? 20.68898 3.27083   -64.57053  1.000 30.95655  ? 605 HOH B O   1 
HETATM 6744 O  O   . HOH N 5 .   ? 30.22548 -9.82226  -87.11009  1.000 39.29490  ? 606 HOH B O   1 
HETATM 6745 O  O   . HOH N 5 .   ? 6.83113  11.90355  -77.31886  1.000 31.14627  ? 607 HOH B O   1 
HETATM 6746 O  O   . HOH N 5 .   ? 11.50334 14.76404  -71.46760  1.000 21.18803  ? 608 HOH B O   1 
HETATM 6747 O  O   . HOH N 5 .   ? 27.03202 30.18798  -64.53753  1.000 33.65837  ? 609 HOH B O   1 
HETATM 6748 O  O   . HOH N 5 .   ? 32.51659 29.15429  -64.78674  1.000 17.95774  ? 610 HOH B O   1 
HETATM 6749 O  O   . HOH N 5 .   ? 45.71371 7.22011   -75.89948  1.000 34.96566  ? 611 HOH B O   1 
HETATM 6750 O  O   . HOH N 5 .   ? 7.99004  10.17293  -79.32794  1.000 30.94809  ? 612 HOH B O   1 
HETATM 6751 O  O   . HOH N 5 .   ? 18.17796 12.50645  -83.17060  1.000 27.50656  ? 613 HOH B O   1 
HETATM 6752 O  O   . HOH N 5 .   ? 2.69126  7.27429   -76.73232  1.000 35.23334  ? 614 HOH B O   1 
HETATM 6753 O  O   . HOH N 5 .   ? 37.28327 -1.82936  -62.53792  1.000 25.68342  ? 615 HOH B O   1 
HETATM 6754 O  O   . HOH N 5 .   ? 32.64370 -5.49240  -88.43172  1.000 31.27522  ? 616 HOH B O   1 
HETATM 6755 O  O   . HOH N 5 .   ? 25.49381 -5.90602  -73.96567  1.000 12.89769  ? 617 HOH B O   1 
HETATM 6756 O  O   . HOH N 5 .   ? 26.59242 20.55964  -71.53392  1.000 17.64942  ? 618 HOH B O   1 
HETATM 6757 O  O   . HOH N 5 .   ? 23.04497 2.60878   -61.29898  1.000 39.34595  ? 619 HOH B O   1 
HETATM 6758 O  O   . HOH N 5 .   ? 30.73371 33.69182  -84.65144  1.000 30.27897  ? 620 HOH B O   1 
HETATM 6759 O  O   . HOH N 5 .   ? 7.58889  3.34488   -59.16442  1.000 25.50160  ? 621 HOH B O   1 
HETATM 6760 O  O   . HOH N 5 .   ? 16.53211 16.42521  -50.57065  1.000 42.30101  ? 622 HOH B O   1 
HETATM 6761 O  O   . HOH N 5 .   ? 5.53679  8.72451   -47.67995  1.000 39.33761  ? 623 HOH B O   1 
HETATM 6762 O  O   . HOH N 5 .   ? 42.58254 21.27145  -83.89026  1.000 37.56293  ? 624 HOH B O   1 
HETATM 6763 O  O   . HOH N 5 .   ? 11.01298 19.59840  -52.59235  1.000 44.76275  ? 625 HOH B O   1 
HETATM 6764 O  O   . HOH N 5 .   ? 15.90519 19.82235  -89.65061  1.000 24.50123  ? 626 HOH B O   1 
HETATM 6765 O  O   . HOH N 5 .   ? 30.23373 6.79417   -69.77632  1.000 28.54215  ? 627 HOH B O   1 
HETATM 6766 O  O   . HOH N 5 .   ? 29.21421 22.41718  -85.74040  1.000 24.67575  ? 628 HOH B O   1 
HETATM 6767 O  O   . HOH N 5 .   ? 38.64659 27.43207  -58.63319  1.000 28.65752  ? 629 HOH B O   1 
HETATM 6768 O  O   . HOH N 5 .   ? 27.55557 24.93887  -87.40613  1.000 25.46566  ? 630 HOH B O   1 
HETATM 6769 O  O   . HOH N 5 .   ? 17.31387 11.42840  -97.22323  1.000 38.16942  ? 631 HOH B O   1 
HETATM 6770 O  O   . HOH N 5 .   ? 23.16698 12.53086  -84.20223  1.000 25.23807  ? 632 HOH B O   1 
HETATM 6771 O  O   . HOH N 5 .   ? 7.95081  14.53998  -90.33560  1.000 44.76025  ? 633 HOH B O   1 
HETATM 6772 O  O   . HOH N 5 .   ? 43.29438 19.20805  -63.54964  1.000 23.80828  ? 634 HOH B O   1 
HETATM 6773 O  O   . HOH N 5 .   ? 27.75805 33.28518  -66.19388  1.000 35.67671  ? 635 HOH B O   1 
HETATM 6774 O  O   . HOH N 5 .   ? 36.55506 -3.48409  -70.39778  1.000 17.65459  ? 636 HOH B O   1 
HETATM 6775 O  O   . HOH N 5 .   ? 34.92233 18.38690  -90.03854  1.000 41.95026  ? 637 HOH B O   1 
HETATM 6776 O  O   . HOH N 5 .   ? 35.60873 18.36991  -69.70801  1.000 15.66202  ? 638 HOH B O   1 
HETATM 6777 O  O   . HOH N 5 .   ? 8.58090  21.00970  -89.33621  1.000 33.61348  ? 639 HOH B O   1 
HETATM 6778 O  O   . HOH N 5 .   ? 49.88585 11.13580  -72.01030  1.000 24.77903  ? 640 HOH B O   1 
HETATM 6779 O  O   . HOH N 5 .   ? 33.17921 20.35058  -56.80765  1.000 20.79116  ? 641 HOH B O   1 
HETATM 6780 O  O   . HOH N 5 .   ? 15.12698 33.30143  -79.28431  1.000 25.84777  ? 642 HOH B O   1 
HETATM 6781 O  O   . HOH N 5 .   ? 43.73120 6.82480   -78.11966  1.000 22.12792  ? 643 HOH B O   1 
HETATM 6782 O  O   . HOH N 5 .   ? 19.75103 14.49864  -93.00737  1.000 20.51849  ? 644 HOH B O   1 
HETATM 6783 O  O   . HOH N 5 .   ? 22.61681 -3.15555  -78.66094  1.000 23.43901  ? 645 HOH B O   1 
HETATM 6784 O  O   . HOH N 5 .   ? 22.90472 -9.82068  -87.73099  1.000 33.23390  ? 646 HOH B O   1 
HETATM 6785 O  O   . HOH N 5 .   ? 13.49116 -0.90794  -89.17304  1.000 39.42595  ? 647 HOH B O   1 
HETATM 6786 O  O   . HOH N 5 .   ? 11.16056 9.95745   -70.30747  1.000 23.05016  ? 648 HOH B O   1 
HETATM 6787 O  O   . HOH N 5 .   ? 29.47266 22.45645  -71.49931  1.000 19.02758  ? 649 HOH B O   1 
HETATM 6788 O  O   . HOH N 5 .   ? 20.05066 9.83821   -86.39010  1.000 30.25748  ? 650 HOH B O   1 
HETATM 6789 O  O   . HOH N 5 .   ? 27.39886 -2.96832  -93.49861  1.000 31.11367  ? 651 HOH B O   1 
HETATM 6790 O  O   . HOH N 5 .   ? 25.28488 12.63128  -78.82762  1.000 14.96051  ? 652 HOH B O   1 
HETATM 6791 O  O   . HOH N 5 .   ? 3.34225  5.17130   -74.80549  1.000 29.77627  ? 653 HOH B O   1 
HETATM 6792 O  O   . HOH N 5 .   ? 11.74136 -2.63177  -58.22205  1.000 19.10069  ? 654 HOH B O   1 
HETATM 6793 O  O   . HOH N 5 .   ? 42.32770 2.72730   -64.34969  1.000 29.23729  ? 655 HOH B O   1 
HETATM 6794 O  O   . HOH N 5 .   ? 47.90710 19.27875  -69.34115  1.000 29.54322  ? 656 HOH B O   1 
HETATM 6795 O  O   . HOH N 5 .   ? 15.90519 24.87412  -85.68072  1.000 34.59609  ? 657 HOH B O   1 
HETATM 6796 O  O   . HOH N 5 .   ? 2.08113  6.16558   -72.52855  1.000 28.02848  ? 658 HOH B O   1 
HETATM 6797 O  O   . HOH N 5 .   ? 38.93558 -7.79220  -73.97399  1.000 25.14259  ? 659 HOH B O   1 
HETATM 6798 O  O   . HOH N 5 .   ? 36.38211 19.66400  -64.41428  1.000 20.09628  ? 660 HOH B O   1 
HETATM 6799 O  O   . HOH N 5 .   ? 10.13996 14.65656  -61.81548  1.000 12.91652  ? 661 HOH B O   1 
HETATM 6800 O  O   . HOH N 5 .   ? 7.012    10.488    -48.853    1.000 31.29227  ? 662 HOH B O   1 
HETATM 6801 O  O   . HOH N 5 .   ? 18.00643 -2.24288  -80.22145  1.000 26.31949  ? 663 HOH B O   1 
HETATM 6802 O  O   . HOH N 5 .   ? 34.88607 25.08793  -58.48602  1.000 22.48731  ? 664 HOH B O   1 
HETATM 6803 O  O   . HOH N 5 .   ? 13.92812 26.95380  -59.81192  1.000 35.59971  ? 665 HOH B O   1 
HETATM 6804 O  O   . HOH N 5 .   ? 11.90076 19.43279  -55.82448  1.000 37.63334  ? 666 HOH B O   1 
HETATM 6805 O  O   . HOH N 5 .   ? 12.56822 9.80369   -64.63723  1.000 18.99251  ? 667 HOH B O   1 
HETATM 6806 O  O   . HOH N 5 .   ? 30.96696 19.91431  -89.28202  1.000 46.40602  ? 668 HOH B O   1 
HETATM 6807 O  O   . HOH N 5 .   ? 30.68144 26.26662  -54.94852  1.000 28.60962  ? 669 HOH B O   1 
HETATM 6808 O  O   . HOH N 5 .   ? 12.93585 34.52929  -67.16267  1.000 26.52425  ? 670 HOH B O   1 
HETATM 6809 O  O   . HOH N 5 .   ? 31.10025 4.26273   -96.31204  1.000 39.97855  ? 671 HOH B O   1 
HETATM 6810 O  O   . HOH N 5 .   ? 13.33870 4.56409   -55.23682  1.000 14.43349  ? 672 HOH B O   1 
HETATM 6811 O  O   . HOH N 5 .   ? 22.00147 8.06093   -92.67215  1.000 22.59672  ? 673 HOH B O   1 
HETATM 6812 O  O   . HOH N 5 .   ? 21.18000 12.32242  -77.46710  1.000 17.27909  ? 674 HOH B O   1 
HETATM 6813 O  O   . HOH N 5 .   ? 11.24061 16.43435  -65.54757  1.000 17.46079  ? 675 HOH B O   1 
HETATM 6814 O  O   . HOH N 5 .   ? 6.83078  36.19867  -80.67052  1.000 25.59437  ? 676 HOH B O   1 
HETATM 6815 O  O   . HOH N 5 .   ? 12.96930 7.90337   -62.67067  1.000 20.08932  ? 677 HOH B O   1 
HETATM 6816 O  O   . HOH N 5 .   ? 38.11081 19.09649  -60.04161  1.000 20.03427  ? 678 HOH B O   1 
HETATM 6817 O  O   . HOH N 5 .   ? 38.30170 9.38703   -62.60272  1.000 40.19722  ? 679 HOH B O   1 
HETATM 6818 O  O   . HOH N 5 .   ? 25.10969 12.88794  -97.35398  1.000 40.45305  ? 680 HOH B O   1 
HETATM 6819 O  O   . HOH N 5 .   ? 13.08976 10.15965  -67.21086  1.000 29.67598  ? 681 HOH B O   1 
HETATM 6820 O  O   . HOH N 5 .   ? 45.23200 7.96078   -85.34848  1.000 40.27631  ? 682 HOH B O   1 
HETATM 6821 O  O   . HOH N 5 .   ? 23.62643 14.67188  -81.59264  1.000 20.88571  ? 683 HOH B O   1 
HETATM 6822 O  O   . HOH N 5 .   ? 4.321    10.664    -76.090    1.000 28.68797  ? 684 HOH B O   1 
HETATM 6823 O  O   . HOH N 5 .   ? 41.92138 35.69213  -74.02059  1.000 31.51314  ? 685 HOH B O   1 
HETATM 6824 O  O   . HOH N 5 .   ? 45.280   -4.998    -71.213    1.000 29.40584  ? 686 HOH B O   1 
HETATM 6825 O  O   . HOH N 5 .   ? 34.23863 2.79557   -94.91506  1.000 34.03133  ? 687 HOH B O   1 
HETATM 6826 O  O   . HOH N 5 .   ? 11.27611 11.77353  -72.05794  1.000 23.27296  ? 688 HOH B O   1 
HETATM 6827 O  O   . HOH N 5 .   ? 43.16422 32.57504  -67.13418  1.000 43.12702  ? 689 HOH B O   1 
HETATM 6828 O  O   . HOH N 5 .   ? 31.29752 -4.47676  -65.21891  1.000 25.20900  ? 690 HOH B O   1 
HETATM 6829 O  O   . HOH N 5 .   ? 9.02241  -2.79014  -70.57204  1.000 23.43448  ? 691 HOH B O   1 
HETATM 6830 O  O   . HOH N 5 .   ? 30.03977 26.17373  -88.04297  1.000 28.81116  ? 692 HOH B O   1 
HETATM 6831 O  O   . HOH N 5 .   ? 11.58448 22.50929  -57.20639  1.000 39.52697  ? 693 HOH B O   1 
HETATM 6832 O  O   . HOH N 5 .   ? 25.64904 18.49237  -68.15814  1.000 15.77813  ? 694 HOH B O   1 
HETATM 6833 O  O   . HOH N 5 .   ? 37.80675 -11.39094 -71.48904  1.000 28.28561  ? 695 HOH B O   1 
HETATM 6834 O  O   . HOH N 5 .   ? 4.10818  5.93449   -50.85976  1.000 31.90647  ? 696 HOH B O   1 
HETATM 6835 O  O   . HOH N 5 .   ? 19.49368 -6.23780  -88.68322  1.000 26.14077  ? 697 HOH B O   1 
HETATM 6836 O  O   . HOH N 5 .   ? 14.77570 12.63989  -72.39122  1.000 23.59053  ? 698 HOH B O   1 
HETATM 6837 O  O   . HOH N 5 .   ? 42.03547 23.78719  -79.43105  1.000 36.81240  ? 699 HOH B O   1 
HETATM 6838 O  O   . HOH N 5 .   ? 12.05679 29.19173  -74.49573  1.000 19.46038  ? 700 HOH B O   1 
HETATM 6839 O  O   . HOH N 5 .   ? 20.89440 16.91159  -93.78515  1.000 27.35686  ? 701 HOH B O   1 
HETATM 6840 O  O   . HOH N 5 .   ? 11.85415 17.40673  -47.86403  1.000 39.30647  ? 702 HOH B O   1 
HETATM 6841 O  O   . HOH N 5 .   ? 16.64560 -2.88046  -91.42415  1.000 27.04582  ? 703 HOH B O   1 
HETATM 6842 O  O   . HOH N 5 .   ? 20.28195 15.23089  -56.01414  1.000 16.43667  ? 704 HOH B O   1 
HETATM 6843 O  O   . HOH N 5 .   ? 19.28937 3.89493   -57.24621  1.000 16.96519  ? 705 HOH B O   1 
HETATM 6844 O  O   . HOH N 5 .   ? 42.22949 33.96472  -77.59873  1.000 32.38435  ? 706 HOH B O   1 
HETATM 6845 O  O   . HOH N 5 .   ? 29.98810 17.08973  -61.97932  1.000 15.34346  ? 707 HOH B O   1 
HETATM 6846 O  O   . HOH N 5 .   ? 10.44613 28.04347  -62.18895  1.000 26.82487  ? 708 HOH B O   1 
HETATM 6847 O  O   . HOH N 5 .   ? 13.964   -7.332    -85.810    1.000 33.41401  ? 709 HOH B O   1 
HETATM 6848 O  O   . HOH N 5 .   ? 36.329   -11.140   -66.386    1.000 42.49500  ? 710 HOH B O   1 
HETATM 6849 O  O   . HOH N 5 .   ? 39.62063 -3.71676  -65.56174  1.000 33.06607  ? 711 HOH B O   1 
HETATM 6850 O  O   . HOH N 5 .   ? 20.52986 21.05040  -101.56740 1.000 58.49180  ? 712 HOH B O   1 
HETATM 6851 O  O   . HOH N 5 .   ? 44.67317 12.03331  -62.10066  1.000 36.82470  ? 713 HOH B O   1 
HETATM 6852 O  O   . HOH N 5 .   ? 32.57564 13.32823  -94.37290  1.000 28.98125  ? 714 HOH B O   1 
HETATM 6853 O  O   . HOH N 5 .   ? 24.46009 -4.63428  -67.61914  1.000 15.48003  ? 715 HOH B O   1 
HETATM 6854 O  O   . HOH N 5 .   ? 23.63390 2.14912   -91.23806  1.000 21.27291  ? 716 HOH B O   1 
HETATM 6855 O  O   . HOH N 5 .   ? 4.66636  5.56036   -68.45157  1.000 25.92924  ? 717 HOH B O   1 
HETATM 6856 O  O   . HOH N 5 .   ? 11.11520 19.97276  -82.43269  1.000 21.20240  ? 718 HOH B O   1 
HETATM 6857 O  O   . HOH N 5 .   ? 37.62843 37.39059  -81.22121  1.000 39.45937  ? 719 HOH B O   1 
HETATM 6858 O  O   . HOH N 5 .   ? 6.780    22.851    -75.167    1.000 21.72650  ? 720 HOH B O   1 
HETATM 6859 O  O   . HOH N 5 .   ? 10.76120 26.25957  -85.68724  1.000 31.68671  ? 721 HOH B O   1 
HETATM 6860 O  O   . HOH N 5 .   ? 17.99031 11.96273  -85.69519  1.000 31.64050  ? 722 HOH B O   1 
HETATM 6861 O  O   . HOH N 5 .   ? 18.07026 -2.20977  -94.17688  1.000 43.39086  ? 723 HOH B O   1 
HETATM 6862 O  O   . HOH N 5 .   ? 23.39339 18.03188  -50.16742  1.000 33.69416  ? 724 HOH B O   1 
HETATM 6863 O  O   . HOH N 5 .   ? 5.05324  12.75703  -68.21086  1.000 17.21866  ? 725 HOH B O   1 
HETATM 6864 O  O   . HOH N 5 .   ? 30.50889 15.21587  -72.69123  1.000 13.33690  ? 726 HOH B O   1 
HETATM 6865 O  O   . HOH N 5 .   ? 37.33152 21.10562  -58.32591  1.000 24.08513  ? 727 HOH B O   1 
HETATM 6866 O  O   . HOH N 5 .   ? 31.56934 23.47212  -73.50471  1.000 16.12346  ? 728 HOH B O   1 
HETATM 6867 O  O   . HOH N 5 .   ? 7.99625  1.92342   -76.24955  1.000 26.40526  ? 729 HOH B O   1 
HETATM 6868 O  O   . HOH N 5 .   ? 10.38070 28.83756  -84.85889  1.000 25.32484  ? 730 HOH B O   1 
HETATM 6869 O  O   . HOH N 5 .   ? 37.58017 30.04863  -59.97193  1.000 25.94364  ? 731 HOH B O   1 
HETATM 6870 O  O   . HOH N 5 .   ? 37.47381 17.60640  -89.05038  1.000 34.36197  ? 732 HOH B O   1 
HETATM 6871 O  O   . HOH N 5 .   ? 28.14385 24.08257  -91.48050  1.000 40.26575  ? 733 HOH B O   1 
HETATM 6872 O  O   . HOH N 5 .   ? 21.93576 16.78795  -59.26696  1.000 18.34394  ? 734 HOH B O   1 
HETATM 6873 O  O   . HOH N 5 .   ? 50.47422 13.93409  -71.32022  1.000 27.37068  ? 735 HOH B O   1 
HETATM 6874 O  O   . HOH N 5 .   ? 4.36972  15.22721  -67.19378  1.000 27.14300  ? 736 HOH B O   1 
HETATM 6875 O  O   . HOH N 5 .   ? 34.15166 23.94317  -72.33674  1.000 14.94063  ? 737 HOH B O   1 
HETATM 6876 O  O   . HOH N 5 .   ? 12.78880 17.53770  -52.15875  1.000 22.74115  ? 738 HOH B O   1 
HETATM 6877 O  O   . HOH N 5 .   ? 32.50851 -2.84116  -61.66421  1.000 35.23155  ? 739 HOH B O   1 
HETATM 6878 O  O   . HOH N 5 .   ? 20.81211 5.04252   -60.30865  1.000 30.35921  ? 740 HOH B O   1 
HETATM 6879 O  O   . HOH N 5 .   ? 18.40242 -1.83885  -82.81683  1.000 25.23748  ? 741 HOH B O   1 
HETATM 6880 O  O   . HOH N 5 .   ? 43.94234 3.69892   -85.68883  1.000 35.68672  ? 742 HOH B O   1 
HETATM 6881 O  O   . HOH N 5 .   ? 15.70159 33.14446  -74.48717  1.000 27.03943  ? 743 HOH B O   1 
HETATM 6882 O  O   . HOH N 5 .   ? 45.61315 19.87784  -67.97259  1.000 29.90552  ? 744 HOH B O   1 
HETATM 6883 O  O   . HOH N 5 .   ? 8.35391  12.24047  -81.76068  1.000 41.07648  ? 745 HOH B O   1 
HETATM 6884 O  O   . HOH N 5 .   ? 21.29698 2.00580   -94.36242  1.000 40.69291  ? 746 HOH B O   1 
HETATM 6885 O  O   . HOH N 5 .   ? 40.40500 4.95856   -63.83962  1.000 32.09147  ? 747 HOH B O   1 
HETATM 6886 O  O   . HOH N 5 .   ? 25.01633 6.88912   -65.68117  1.000 42.04869  ? 748 HOH B O   1 
HETATM 6887 O  O   . HOH N 5 .   ? 20.49363 34.67340  -67.20651  1.000 32.34973  ? 749 HOH B O   1 
HETATM 6888 O  O   . HOH N 5 .   ? 15.71469 30.99462  -89.83221  1.000 36.42377  ? 750 HOH B O   1 
HETATM 6889 O  O   . HOH N 5 .   ? 15.79928 19.90482  -60.47996  1.000 17.06926  ? 751 HOH B O   1 
HETATM 6890 O  O   . HOH N 5 .   ? 46.32701 23.79973  -71.54418  1.000 41.70696  ? 752 HOH B O   1 
HETATM 6891 O  O   . HOH N 5 .   ? 21.31717 37.15007  -72.59591  1.000 26.70673  ? 753 HOH B O   1 
HETATM 6892 O  O   . HOH N 5 .   ? 37.31453 17.35145  -58.83181  1.000 33.61549  ? 754 HOH B O   1 
HETATM 6893 O  O   . HOH N 5 .   ? 30.00954 -0.03475  -60.91409  1.000 44.61716  ? 755 HOH B O   1 
HETATM 6894 O  O   . HOH N 5 .   ? 42.20306 -3.20233  -81.46789  1.000 45.69148  ? 756 HOH B O   1 
HETATM 6895 O  O   . HOH N 5 .   ? 38.91845 24.93789  -80.43544  1.000 26.52992  ? 757 HOH B O   1 
HETATM 6896 O  O   . HOH N 5 .   ? 22.51210 13.73900  -55.75833  1.000 22.79717  ? 758 HOH B O   1 
HETATM 6897 O  O   . HOH N 5 .   ? 46.29317 1.98962   -75.72206  1.000 38.45707  ? 759 HOH B O   1 
HETATM 6898 O  O   . HOH N 5 .   ? 16.77268 -6.85604  -79.31344  1.000 22.93382  ? 760 HOH B O   1 
HETATM 6899 O  O   . HOH N 5 .   ? 17.98950 15.60892  -96.80521  1.000 37.64341  ? 761 HOH B O   1 
HETATM 6900 O  O   . HOH N 5 .   ? 15.58564 9.97127   -45.33234  1.000 20.56636  ? 762 HOH B O   1 
HETATM 6901 O  O   . HOH N 5 .   ? 27.98690 18.41032  -78.60529  1.000 24.27887  ? 763 HOH B O   1 
HETATM 6902 O  O   . HOH N 5 .   ? 3.31736  -1.90918  -73.54638  1.000 34.16660  ? 764 HOH B O   1 
HETATM 6903 O  O   . HOH N 5 .   ? 42.28094 8.66510   -89.91202  1.000 32.05891  ? 765 HOH B O   1 
HETATM 6904 O  O   . HOH N 5 .   ? 35.05751 26.52715  -72.34480  1.000 17.12198  ? 766 HOH B O   1 
HETATM 6905 O  O   . HOH N 5 .   ? 25.15207 23.39785  -54.75039  1.000 43.78723  ? 767 HOH B O   1 
HETATM 6906 O  O   . HOH N 5 .   ? 33.71397 7.16796   -74.35882  1.000 18.19052  ? 768 HOH B O   1 
HETATM 6907 O  O   . HOH N 5 .   ? 32.01739 8.59590   -76.10397  1.000 18.92364  ? 769 HOH B O   1 
HETATM 6908 O  O   . HOH N 5 .   ? 19.82037 17.25500  -96.31086  1.000 30.64482  ? 770 HOH B O   1 
HETATM 6909 O  O   . HOH N 5 .   ? 28.53458 21.91157  -66.97739  1.000 20.87883  ? 771 HOH B O   1 
HETATM 6910 O  O   . HOH N 5 .   ? 39.19590 -1.80386  -64.38162  1.000 31.99396  ? 772 HOH B O   1 
HETATM 6911 O  O   . HOH N 5 .   ? 19.24432 -0.91338  -58.21014  1.000 40.09698  ? 773 HOH B O   1 
HETATM 6912 O  O   . HOH N 5 .   ? 41.23366 29.09754  -62.38317  1.000 28.80732  ? 774 HOH B O   1 
HETATM 6913 O  O   . HOH N 5 .   ? 24.23929 1.57388   -94.65218  1.000 36.56395  ? 775 HOH B O   1 
HETATM 6914 O  O   . HOH N 5 .   ? 9.96943  -2.35194  -51.39443  1.000 20.67453  ? 776 HOH B O   1 
HETATM 6915 O  O   . HOH N 5 .   ? 32.71322 7.43525   -71.81580  1.000 22.52337  ? 777 HOH B O   1 
HETATM 6916 O  O   . HOH N 5 .   ? 33.97600 -6.08005  -63.16051  1.000 27.07362  ? 778 HOH B O   1 
HETATM 6917 O  O   . HOH N 5 .   ? 14.52253 -0.25715  -85.98433  1.000 22.75253  ? 779 HOH B O   1 
HETATM 6918 O  O   . HOH N 5 .   ? 39.09917 27.23324  -71.91230  1.000 20.01421  ? 780 HOH B O   1 
HETATM 6919 O  O   . HOH N 5 .   ? 6.64395  3.36562   -78.68337  1.000 33.16913  ? 781 HOH B O   1 
HETATM 6920 O  O   . HOH N 5 .   ? 18.40199 33.03226  -76.37214  1.000 34.83513  ? 782 HOH B O   1 
HETATM 6921 O  O   . HOH N 5 .   ? 21.45317 9.72524   -97.86087  1.000 41.61071  ? 783 HOH B O   1 
HETATM 6922 O  O   . HOH N 5 .   ? 3.67083  -4.64053  -93.79124  1.000 61.61877  ? 784 HOH B O   1 
HETATM 6923 O  O   . HOH N 5 .   ? 23.03701 10.35380  -49.71572  1.000 32.83042  ? 785 HOH B O   1 
HETATM 6924 O  O   . HOH N 5 .   ? 46.67657 9.29563   -77.23527  1.000 34.71756  ? 786 HOH B O   1 
HETATM 6925 O  O   . HOH N 5 .   ? 44.29559 0.92283   -68.84188  1.000 24.41021  ? 787 HOH B O   1 
HETATM 6926 O  O   . HOH N 5 .   ? 29.64887 29.67593  -63.87982  1.000 31.38062  ? 788 HOH B O   1 
HETATM 6927 O  O   . HOH N 5 .   ? 34.16407 -5.23363  -84.23931  1.000 38.06268  ? 789 HOH B O   1 
HETATM 6928 O  O   . HOH N 5 .   ? 15.83164 13.20929  -87.18987  1.000 25.65026  ? 790 HOH B O   1 
HETATM 6929 O  O   . HOH N 5 .   ? 26.29766 37.20610  -81.87693  1.000 33.43171  ? 791 HOH B O   1 
HETATM 6930 O  O   . HOH N 5 .   ? 39.40685 32.13448  -59.67804  1.000 44.55101  ? 792 HOH B O   1 
HETATM 6931 O  O   . HOH N 5 .   ? 7.67819  2.80672   -50.81057  1.000 27.23821  ? 793 HOH B O   1 
HETATM 6932 O  O   . HOH N 5 .   ? 27.76065 -7.53301  -73.48231  1.000 13.49040  ? 794 HOH B O   1 
HETATM 6933 O  O   . HOH N 5 .   ? 31.67207 17.12194  -95.58797  1.000 47.02398  ? 795 HOH B O   1 
HETATM 6934 O  O   . HOH N 5 .   ? 14.74402 35.22420  -71.33932  1.000 27.33607  ? 796 HOH B O   1 
HETATM 6935 O  O   . HOH N 5 .   ? 4.93271  4.15134   -54.42429  1.000 26.86981  ? 797 HOH B O   1 
HETATM 6936 O  O   . HOH N 5 .   ? 9.93246  27.58315  -74.77334  1.000 15.09271  ? 798 HOH B O   1 
HETATM 6937 O  O   . HOH N 5 .   ? 27.03984 10.24873  -62.62359  1.000 23.58430  ? 799 HOH B O   1 
HETATM 6938 O  O   . HOH N 5 .   ? 4.06869  8.00987   -52.40499  1.000 40.57293  ? 800 HOH B O   1 
HETATM 6939 O  O   . HOH N 5 .   ? 3.97981  10.11371  -68.39986  1.000 23.08290  ? 801 HOH B O   1 
HETATM 6940 O  O   . HOH N 5 .   ? 46.93368 5.39283   -74.42330  1.000 38.49198  ? 802 HOH B O   1 
HETATM 6941 O  O   . HOH N 5 .   ? 25.26622 5.61972   -63.59123  1.000 40.40625  ? 803 HOH B O   1 
HETATM 6942 O  O   . HOH N 5 .   ? 25.59085 26.59303  -89.28374  1.000 33.25952  ? 804 HOH B O   1 
HETATM 6943 O  O   . HOH N 5 .   ? 19.34896 30.78459  -60.99691  1.000 26.30967  ? 805 HOH B O   1 
HETATM 6944 O  O   . HOH N 5 .   ? 31.88869 32.27292  -63.47133  1.000 36.20733  ? 806 HOH B O   1 
HETATM 6945 O  O   . HOH N 5 .   ? 15.74325 -0.67050  -81.74997  1.000 36.11581  ? 807 HOH B O   1 
HETATM 6946 O  O   . HOH N 5 .   ? 32.12213 32.77459  -86.94148  1.000 34.58404  ? 808 HOH B O   1 
HETATM 6947 O  O   . HOH N 5 .   ? 22.27970 11.65762  -86.63796  1.000 22.54550  ? 809 HOH B O   1 
HETATM 6948 O  O   . HOH N 5 .   ? 14.74147 35.53951  -83.04835  1.000 34.88298  ? 810 HOH B O   1 
HETATM 6949 O  O   . HOH N 5 .   ? 27.05042 17.21139  -57.90632  1.000 35.65316  ? 811 HOH B O   1 
HETATM 6950 O  O   . HOH N 5 .   ? 2.03252  2.98292   -55.34270  1.000 34.29852  ? 812 HOH B O   1 
HETATM 6951 O  O   . HOH N 5 .   ? 38.64206 37.17002  -70.67318  1.000 34.13460  ? 813 HOH B O   1 
HETATM 6952 O  O   . HOH N 5 .   ? 38.88128 3.35466   -65.63933  1.000 31.83820  ? 814 HOH B O   1 
HETATM 6953 O  O   . HOH N 5 .   ? 27.46266 20.52116  -69.00147  1.000 16.05986  ? 815 HOH B O   1 
HETATM 6954 O  O   . HOH N 5 .   ? 17.19249 33.73116  -69.50979  1.000 25.30420  ? 816 HOH B O   1 
HETATM 6955 O  O   . HOH N 5 .   ? 39.35636 6.10490   -61.55599  1.000 44.18360  ? 817 HOH B O   1 
HETATM 6956 O  O   . HOH N 5 .   ? 28.56392 32.18447  -86.25611  1.000 47.07011  ? 818 HOH B O   1 
HETATM 6957 O  O   . HOH N 5 .   ? 34.07589 35.42306  -63.29873  1.000 38.49131  ? 819 HOH B O   1 
HETATM 6958 O  O   . HOH N 5 .   ? 34.30264 -8.56700  -82.36037  1.000 28.15433  ? 820 HOH B O   1 
HETATM 6959 O  O   . HOH N 5 .   ? 25.43463 13.26046  -59.53899  1.000 24.80737  ? 821 HOH B O   1 
HETATM 6960 O  O   . HOH N 5 .   ? 16.47329 28.55574  -89.06575  1.000 37.64916  ? 822 HOH B O   1 
HETATM 6961 O  O   . HOH N 5 .   ? 23.45506 6.23800   -61.11714  1.000 34.17205  ? 823 HOH B O   1 
HETATM 6962 O  O   . HOH N 5 .   ? 41.78689 7.62225   -92.94346  1.000 39.25085  ? 824 HOH B O   1 
HETATM 6963 O  O   . HOH N 5 .   ? 32.85751 18.38085  -87.92862  1.000 40.82505  ? 825 HOH B O   1 
HETATM 6964 O  O   . HOH N 5 .   ? 34.68042 2.63045   -61.06964  1.000 39.65979  ? 826 HOH B O   1 
HETATM 6965 O  O   . HOH N 5 .   ? 38.84369 16.15547  -90.46511  1.000 31.55502  ? 827 HOH B O   1 
HETATM 6966 O  O   . HOH N 5 .   ? 24.34757 1.34685   -88.79498  1.000 26.12335  ? 828 HOH B O   1 
HETATM 6967 O  O   . HOH N 5 .   ? 27.36607 -4.09805  -55.97786  1.000 40.19591  ? 829 HOH B O   1 
HETATM 6968 O  O   . HOH N 5 .   ? 41.07560 -0.49825  -87.10299  1.000 51.24140  ? 830 HOH B O   1 
HETATM 6969 O  O   . HOH N 5 .   ? 45.63002 28.49040  -75.68355  1.000 39.65266  ? 831 HOH B O   1 
HETATM 6970 O  O   . HOH N 5 .   ? 12.79568 1.94851   -87.60920  1.000 39.59829  ? 832 HOH B O   1 
HETATM 6971 O  O   . HOH N 5 .   ? 42.59304 -6.62891  -75.00289  1.000 36.59668  ? 833 HOH B O   1 
HETATM 6972 O  O   . HOH N 5 .   ? 13.77416 36.05618  -77.30570  1.000 24.88979  ? 834 HOH B O   1 
HETATM 6973 O  O   . HOH N 5 .   ? 41.18052 0.63691   -84.15524  1.000 38.18263  ? 835 HOH B O   1 
HETATM 6974 O  O   . HOH N 5 .   ? 22.91434 1.69365   -58.72424  1.000 47.02630  ? 836 HOH B O   1 
HETATM 6975 O  O   . HOH N 5 .   ? 26.73032 20.30890  -52.85030  1.000 41.53647  ? 837 HOH B O   1 
HETATM 6976 O  O   . HOH N 5 .   ? 11.177   32.214    -87.823    1.000 53.32886  ? 838 HOH B O   1 
HETATM 6977 O  O   . HOH N 5 .   ? 36.59698 21.10830  -86.97194  1.000 38.50192  ? 839 HOH B O   1 
HETATM 6978 O  O   . HOH N 5 .   ? 50.16210 7.31579   -82.43013  1.000 48.30161  ? 840 HOH B O   1 
HETATM 6979 O  O   . HOH N 5 .   ? 6.95581  8.98894   -51.89286  1.000 18.22764  ? 841 HOH B O   1 
HETATM 6980 O  O   . HOH N 5 .   ? 45.62722 25.26219  -67.21377  1.000 28.17616  ? 842 HOH B O   1 
HETATM 6981 O  O   . HOH N 5 .   ? 13.31702 35.54755  -86.96483  1.000 50.56187  ? 843 HOH B O   1 
HETATM 6982 O  O   . HOH N 5 .   ? 23.44134 30.65302  -84.07672  1.000 33.85788  ? 844 HOH B O   1 
HETATM 6983 O  O   . HOH N 5 .   ? 39.94140 12.02892  -62.02915  1.000 34.91187  ? 845 HOH B O   1 
HETATM 6984 O  O   . HOH N 5 .   ? 5.19866  3.12622   -75.95111  1.000 33.36896  ? 846 HOH B O   1 
HETATM 6985 O  O   . HOH N 5 .   ? 37.28781 22.96127  -85.16780  1.000 44.58064  ? 847 HOH B O   1 
HETATM 6986 O  O   . HOH N 5 .   ? 42.17532 13.07482  -62.07024  1.000 38.05246  ? 848 HOH B O   1 
HETATM 6987 O  O   . HOH N 5 .   ? 45.61415 30.42851  -70.45160  1.000 47.15228  ? 849 HOH B O   1 
HETATM 6988 O  O   . HOH N 5 .   ? 47.47723 6.43260   -67.69865  1.000 25.98403  ? 850 HOH B O   1 
HETATM 6989 O  O   . HOH N 5 .   ? 29.98107 10.60056  -63.10113  1.000 24.83255  ? 851 HOH B O   1 
HETATM 6990 O  O   . HOH N 5 .   ? 52.21239 12.67506  -81.93629  1.000 49.67516  ? 852 HOH B O   1 
HETATM 6991 O  O   . HOH N 5 .   ? 43.90933 18.13117  -85.22032  1.000 28.10101  ? 853 HOH B O   1 
HETATM 6992 O  O   . HOH N 5 .   ? 26.035   -10.481   -88.126    1.000 35.28132  ? 854 HOH B O   1 
HETATM 6993 O  O   . HOH N 5 .   ? 44.23701 26.31686  -65.45823  1.000 25.13611  ? 855 HOH B O   1 
HETATM 6994 O  O   . HOH N 5 .   ? 21.98267 15.04952  -47.36487  1.000 36.25492  ? 856 HOH B O   1 
HETATM 6995 O  O   . HOH N 5 .   ? 52.71503 10.42755  -82.96370  1.000 47.14735  ? 857 HOH B O   1 
HETATM 6996 O  O   . HOH N 5 .   ? 49.00572 17.26167  -67.55532  1.000 55.80563  ? 858 HOH B O   1 
HETATM 6997 O  O   . HOH N 5 .   ? 21.12312 34.79657  -83.35153  1.000 48.48477  ? 859 HOH B O   1 
HETATM 6998 O  O   . HOH N 5 .   ? 14.29397 20.20212  -55.05659  1.000 30.97009  ? 860 HOH B O   1 
HETATM 6999 O  O   . HOH N 5 .   ? 11.063   -5.139    -88.338    1.000 48.51808  ? 861 HOH B O   1 
HETATM 7000 O  O   . HOH N 5 .   ? 7.84676  12.78917  -88.39896  1.000 39.67698  ? 862 HOH B O   1 
HETATM 7001 O  O   . HOH N 5 .   ? 16.61794 -4.45277  -79.92842  1.000 40.57752  ? 863 HOH B O   1 
HETATM 7002 O  O   . HOH N 5 .   ? 34.01800 -7.72239  -86.05252  1.000 58.70206  ? 864 HOH B O   1 
HETATM 7003 O  O   . HOH N 5 .   ? 20.02025 34.15795  -86.10970  1.000 41.30491  ? 865 HOH B O   1 
HETATM 7004 O  O   . HOH N 5 .   ? 17.05184 34.41635  -72.62432  1.000 36.50843  ? 866 HOH B O   1 
HETATM 7005 O  O   . HOH N 5 .   ? 30.37190 3.54554   -65.92938  1.000 40.24479  ? 867 HOH B O   1 
HETATM 7006 O  O   . HOH N 5 .   ? 37.90284 -11.23691 -69.13068  1.000 43.39911  ? 868 HOH B O   1 
HETATM 7007 O  O   . HOH N 5 .   ? 37.57226 26.24188  -56.63500  1.000 35.61222  ? 869 HOH B O   1 
HETATM 7008 O  O   . HOH N 5 .   ? 3.285    0.657     -74.846    1.000 45.52092  ? 870 HOH B O   1 
HETATM 7009 O  O   . HOH N 5 .   ? 45.36077 13.76327  -87.74627  1.000 41.18013  ? 871 HOH B O   1 
HETATM 7010 O  O   . HOH N 5 .   ? 41.31494 36.70217  -75.92431  1.000 38.45621  ? 872 HOH B O   1 
HETATM 7011 O  O   . HOH N 5 .   ? 26.13289 3.80607   -57.58867  1.000 54.65473  ? 873 HOH B O   1 
HETATM 7012 O  O   . HOH N 5 .   ? 40.89596 -9.79324  -74.00937  1.000 34.33537  ? 874 HOH B O   1 
HETATM 7013 O  O   . HOH N 5 .   ? 27.17868 26.51618  -91.45115  1.000 44.90880  ? 875 HOH B O   1 
HETATM 7014 O  O   . HOH N 5 .   ? 14.91502 35.28178  -68.98195  1.000 38.18414  ? 876 HOH B O   1 
HETATM 7015 O  O   . HOH N 5 .   ? 27.58061 36.30416  -83.62833  1.000 50.24532  ? 877 HOH B O   1 
HETATM 7016 O  O   . HOH N 5 .   ? 16.78564 5.90666   -42.00455  1.000 46.28875  ? 878 HOH B O   1 
HETATM 7017 O  O   . HOH N 5 .   ? 19.92769 2.86106   -61.71931  1.000 43.77986  ? 879 HOH B O   1 
HETATM 7018 O  O   . HOH N 5 .   ? 5.589    -0.445    -74.935    1.000 43.07701  ? 880 HOH B O   1 
HETATM 7019 O  O   . HOH N 5 .   ? 49.258   9.141     -75.441    1.000 35.90762  ? 881 HOH B O   1 
HETATM 7020 O  O   . HOH N 5 .   ? 39.15884 24.86334  -84.53041  1.000 44.90343  ? 882 HOH B O   1 
HETATM 7021 O  O   . HOH N 5 .   ? 47.34017 8.58454   -62.50142  1.000 46.38871  ? 883 HOH B O   1 
HETATM 7022 O  O   . HOH N 5 .   ? 13.16674 8.44717   -69.20424  1.000 35.82522  ? 884 HOH B O   1 
HETATM 7023 O  O   . HOH N 5 .   ? 8.71663  13.50321  -83.72302  1.000 30.17189  ? 885 HOH B O   1 
HETATM 7024 O  O   . HOH N 5 .   ? 34.16324 17.30124  -57.54855  1.000 43.63276  ? 886 HOH B O   1 
HETATM 7025 O  O   . HOH N 5 .   ? 37.36277 -3.18671  -89.75916  1.000 43.04760  ? 887 HOH B O   1 
HETATM 7026 O  O   . HOH N 5 .   ? 7.717    0.815     -79.365    1.000 51.44071  ? 888 HOH B O   1 
HETATM 7027 O  O   . HOH N 5 .   ? 30.55451 38.56101  -69.29110  1.000 52.72731  ? 889 HOH B O   1 
HETATM 7028 O  O   . HOH N 5 .   ? 4.98258  3.35037   -51.65397  1.000 34.19578  ? 890 HOH B O   1 
HETATM 7029 O  O   . HOH N 5 .   ? 15.79353 36.00362  -78.91219  1.000 36.56336  ? 891 HOH B O   1 
HETATM 7030 O  O   . HOH N 5 .   ? 48.738   6.264     -79.105    1.000 49.68468  ? 892 HOH B O   1 
HETATM 7031 O  O   . HOH N 5 .   ? 49.15559 8.74915   -67.08507  1.000 19.58595  ? 893 HOH B O   1 
HETATM 7032 O  O   . HOH N 5 .   ? 19.43650 8.54372   -45.54494  1.000 24.75006  ? 894 HOH B O   1 
HETATM 7033 O  O   . HOH N 5 .   ? 36.52317 -3.72944  -87.63328  1.000 49.43492  ? 895 HOH B O   1 
HETATM 7034 O  O   . HOH N 5 .   ? 33.11159 35.57284  -86.11226  1.000 45.69425  ? 896 HOH B O   1 
HETATM 7035 O  O   . HOH N 5 .   ? 3.651    9.285     -78.703    1.000 45.62591  ? 897 HOH B O   1 
HETATM 7036 O  O   . HOH N 5 .   ? 50.96241 13.28005  -68.84180  1.000 30.96878  ? 898 HOH B O   1 
HETATM 7037 O  O   . HOH N 5 .   ? 45.81144 26.57312  -62.79650  1.000 42.92532  ? 899 HOH B O   1 
HETATM 7038 O  O   . HOH N 5 .   ? 28.18861 13.30662  -58.15056  1.000 32.53188  ? 900 HOH B O   1 
HETATM 7039 O  O   . HOH N 5 .   ? 14.12869 -1.22575  -83.35319  1.000 35.31500  ? 901 HOH B O   1 
HETATM 7040 O  O   . HOH N 5 .   ? 27.95722 15.18485  -51.05485  1.000 47.54160  ? 902 HOH B O   1 
HETATM 7041 O  O   . HOH N 5 .   ? 25.83008 16.06099  -48.84606  1.000 49.87791  ? 903 HOH B O   1 
HETATM 7042 O  O   . HOH N 5 .   ? 37.543   -4.879    -81.532    1.000 35.49144  ? 904 HOH B O   1 
HETATM 7043 O  O   . HOH N 5 .   ? 30.51276 13.64434  -58.86789  1.000 42.79405  ? 905 HOH B O   1 
HETATM 7044 O  O   . HOH N 5 .   ? 8.03645  1.58309   -48.35748  1.000 32.23153  ? 906 HOH B O   1 
HETATM 7045 O  O   . HOH N 5 .   ? 22.00417 37.75095  -69.94473  1.000 45.38531  ? 907 HOH B O   1 
HETATM 7046 O  O   . HOH N 5 .   ? 46.89929 6.62898   -64.39125  1.000 40.48427  ? 908 HOH B O   1 
HETATM 7047 O  O   . HOH N 5 .   ? 21.93301 3.90061   -57.97033  1.000 30.92968  ? 909 HOH B O   1 
HETATM 7048 O  O   . HOH N 5 .   ? 18.57671 1.63789   -59.66266  1.000 33.11190  ? 910 HOH B O   1 
HETATM 7049 O  O   . HOH N 5 .   ? 6.991    -0.355    -76.983    1.000 38.99933  ? 911 HOH B O   1 
HETATM 7050 O  O   . HOH N 5 .   ? 41.19385 16.32894  -91.42602  1.000 42.09587  ? 912 HOH B O   1 
HETATM 7051 O  O   . HOH N 5 .   ? 1.85100  5.85910   -49.47170  1.000 43.38287  ? 913 HOH B O   1 
HETATM 7052 O  O   . HOH N 5 .   ? 49.81041 15.09388  -65.39887  1.000 43.04830  ? 914 HOH B O   1 
HETATM 7053 O  O   . HOH N 5 .   ? 12.85060 13.79555  -97.12587  1.000 42.74905  ? 915 HOH B O   1 
HETATM 7054 O  O   . HOH N 5 .   ? 42.75097 28.60579  -65.47443  1.000 31.67289  ? 916 HOH B O   1 
HETATM 7055 O  O   . HOH N 5 .   ? 14.56070 11.48024  -98.04654  1.000 46.02722  ? 917 HOH B O   1 
HETATM 7056 O  O   . HOH N 5 .   ? 31.19678 8.12399   -63.23417  1.000 49.30060  ? 918 HOH B O   1 
HETATM 7057 O  O   . HOH N 5 .   ? 40.87612 -5.28374  -80.44945  1.000 40.51575  ? 919 HOH B O   1 
HETATM 7058 O  O   . HOH N 5 .   ? 45.82665 32.55287  -68.53105  1.000 48.72579  ? 920 HOH B O   1 
HETATM 7059 O  O   . HOH N 5 .   ? 43.66707 15.91778  -60.08270  1.000 46.42563  ? 921 HOH B O   1 
HETATM 7060 O  O   . HOH N 5 .   ? 50.69976 19.10906  -67.89594  1.000 50.15124  ? 922 HOH B O   1 
HETATM 7061 O  O   . HOH N 5 .   ? 34.62157 21.42219  -88.55573  1.000 47.17708  ? 923 HOH B O   1 
HETATM 7062 O  O   . HOH N 5 .   ? 23.80518 14.88463  -58.26980  1.000 24.70566  ? 924 HOH B O   1 
HETATM 7063 O  O   . HOH N 5 .   ? 52.30043 14.83570  -73.51320  1.000 34.09924  ? 925 HOH B O   1 
HETATM 7064 O  O   . HOH N 5 .   ? 21.67263 32.56118  -60.74013  1.000 39.11669  ? 926 HOH B O   1 
HETATM 7065 O  O   . HOH N 5 .   ? 45.30702 30.08450  -77.84824  1.000 47.23739  ? 927 HOH B O   1 
HETATM 7066 O  O   . HOH N 5 .   ? 23.87661 37.57184  -67.96022  1.000 42.09143  ? 928 HOH B O   1 
HETATM 7067 O  O   . HOH N 5 .   ? 52.54050 16.08340  -76.26669  1.000 45.15387  ? 929 HOH B O   1 
HETATM 7068 O  O   . HOH N 5 .   ? 49.48749 20.86792  -62.55230  1.000 42.37089  ? 930 HOH B O   1 
HETATM 7069 O  O   . HOH N 5 .   ? 4.28710  -0.55487  -51.98975  1.000 50.91006  ? 931 HOH B O   1 
HETATM 7070 O  O   . HOH N 5 .   ? 25.11535 31.67503  -85.82597  1.000 44.93093  ? 932 HOH B O   1 
HETATM 7071 O  O   . HOH N 5 .   ? 38.73548 -4.84507  -87.86631  1.000 58.30597  ? 933 HOH B O   1 
HETATM 7072 O  O   . HOH N 5 .   ? 52.74583 19.57320  -68.65047  1.000 51.74936  ? 934 HOH B O   1 
HETATM 7073 O  O   . HOH N 5 .   ? 2.95780  1.79649   -50.77964  1.000 44.72261  ? 935 HOH B O   1 
HETATM 7074 O  O   . HOH N 5 .   ? 40.04112 -6.37781  -86.97879  1.000 53.33209  ? 936 HOH B O   1 
HETATM 7075 O  O   . HOH N 5 .   ? 7.98332  -2.04192  -122.22120 1.000 57.03352  ? 937 HOH B O   1 
HETATM 7076 O  O   . HOH N 5 .   ? 7.56361  -3.31251  -124.08869 1.000 66.94242  ? 938 HOH B O   1 
# 
