data_8GJ6
# 
_entry.id   8GJ6 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.401 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8GJ6         pdb_00008gj6 10.2210/pdb8gj6/pdb 
WWPDB D_1000273019 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-02-05 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8GJ6 
_pdbx_database_status.recvd_initial_deposition_date   2023-03-15 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              andrea.mattevi@unipv.it 
_pdbx_contact_author.name_first         Andrea 
_pdbx_contact_author.name_last          Mattevi 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-9523-7128 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Caroli, J.'  1 0000-0001-8954-8045 
'Mattevi, A.' 2 0000-0002-9523-7128 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Distal drug resistance mutations promote covalent inhibitor-adduct Grob fragmentation in LSD1' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Caroli, J.'  1 0000-0001-8954-8045 
primary 'Mattevi, A.' 2 0000-0002-9523-7128 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Lysine-specific histone demethylase 1A' 95051.633 1 1.14.99.66 ? ? ? 
2 polymer     man 'REST corepressor 1' 16459.742 1 ?          ? ? ? 
3 non-polymer syn 
;[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl (2R,3S,4S)-2,3,4-trihydroxy-5-[(1R,3S,3aS,13R)-1-hydroxy-10,11-dimethyl-3-[3-(methylcarbamoyl)phenyl]-4,6-dioxo-2,3,5,6-tetrahydro-1H-benzo[g]pyrrolo[2,1-e]pteridin-8(4H)-yl]pentyl dihydrogen diphosphate (non-preferred name)
;
976.776   1 ?          ? ? ? 
4 non-polymer syn 'POTASSIUM ION' 39.098    1 ?          ? ? ? 
# 
loop_
_entity_name_com.entity_id 
_entity_name_com.name 
1 
;BRAF35-HDAC complex protein BHC110,Flavin-containing amine oxidase domain-containing protein 2,[histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A
;
2 'Protein CoREST' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;GSSHHHHHHSSGLVPRGSHMLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPR
KKEPPRASPPGGLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEER
NAKAEKEKKLPPPPPQAPPEEENESEPEEPSGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLW
LDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSFG
MDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQE
FNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQ
YKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANA
TPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAV
LCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAP
ILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPIT
PGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQATPGVPAQQSPSM
;
;GSSHHHHHHSSGLVPRGSHMLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPR
KKEPPRASPPGGLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEER
NAKAEKEKKLPPPPPQAPPEEENESEPEEPSGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLW
LDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSFG
MDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQE
FNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQ
YKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANA
TPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAV
LCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAP
ILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPIT
PGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQATPGVPAQQSPSM
;
A ? 
2 'polypeptide(L)' no no 
;GPLGSPEFRAKRKPPKGMFLSQEDVEAVSANATAATTVLRQLDMELVSVKRQIQNIKQTNSALKEKLDGGIEPYRLPEVI
QKCNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFVNYRRRFNIDEVLQEWEAE
;
;GPLGSPEFRAKRKPPKGMFLSQEDVEAVSANATAATTVLRQLDMELVSVKRQIQNIKQTNSALKEKLDGGIEPYRLPEVI
QKCNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFVNYRRRFNIDEVLQEWEAE
;
B ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
3 
;[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl (2R,3S,4S)-2,3,4-trihydroxy-5-[(1R,3S,3aS,13R)-1-hydroxy-10,11-dimethyl-3-[3-(methylcarbamoyl)phenyl]-4,6-dioxo-2,3,5,6-tetrahydro-1H-benzo[g]pyrrolo[2,1-e]pteridin-8(4H)-yl]pentyl dihydrogen diphosphate (non-preferred name)
;
ZSI 
4 'POTASSIUM ION' K   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   SER n 
1 3   SER n 
1 4   HIS n 
1 5   HIS n 
1 6   HIS n 
1 7   HIS n 
1 8   HIS n 
1 9   HIS n 
1 10  SER n 
1 11  SER n 
1 12  GLY n 
1 13  LEU n 
1 14  VAL n 
1 15  PRO n 
1 16  ARG n 
1 17  GLY n 
1 18  SER n 
1 19  HIS n 
1 20  MET n 
1 21  LEU n 
1 22  SER n 
1 23  GLY n 
1 24  LYS n 
1 25  LYS n 
1 26  ALA n 
1 27  ALA n 
1 28  ALA n 
1 29  ALA n 
1 30  ALA n 
1 31  ALA n 
1 32  ALA n 
1 33  ALA n 
1 34  ALA n 
1 35  ALA n 
1 36  ALA n 
1 37  ALA n 
1 38  THR n 
1 39  GLY n 
1 40  THR n 
1 41  GLU n 
1 42  ALA n 
1 43  GLY n 
1 44  PRO n 
1 45  GLY n 
1 46  THR n 
1 47  ALA n 
1 48  GLY n 
1 49  GLY n 
1 50  SER n 
1 51  GLU n 
1 52  ASN n 
1 53  GLY n 
1 54  SER n 
1 55  GLU n 
1 56  VAL n 
1 57  ALA n 
1 58  ALA n 
1 59  GLN n 
1 60  PRO n 
1 61  ALA n 
1 62  GLY n 
1 63  LEU n 
1 64  SER n 
1 65  GLY n 
1 66  PRO n 
1 67  ALA n 
1 68  GLU n 
1 69  VAL n 
1 70  GLY n 
1 71  PRO n 
1 72  GLY n 
1 73  ALA n 
1 74  VAL n 
1 75  GLY n 
1 76  GLU n 
1 77  ARG n 
1 78  THR n 
1 79  PRO n 
1 80  ARG n 
1 81  LYS n 
1 82  LYS n 
1 83  GLU n 
1 84  PRO n 
1 85  PRO n 
1 86  ARG n 
1 87  ALA n 
1 88  SER n 
1 89  PRO n 
1 90  PRO n 
1 91  GLY n 
1 92  GLY n 
1 93  LEU n 
1 94  ALA n 
1 95  GLU n 
1 96  PRO n 
1 97  PRO n 
1 98  GLY n 
1 99  SER n 
1 100 ALA n 
1 101 GLY n 
1 102 PRO n 
1 103 GLN n 
1 104 ALA n 
1 105 GLY n 
1 106 PRO n 
1 107 THR n 
1 108 VAL n 
1 109 VAL n 
1 110 PRO n 
1 111 GLY n 
1 112 SER n 
1 113 ALA n 
1 114 THR n 
1 115 PRO n 
1 116 MET n 
1 117 GLU n 
1 118 THR n 
1 119 GLY n 
1 120 ILE n 
1 121 ALA n 
1 122 GLU n 
1 123 THR n 
1 124 PRO n 
1 125 GLU n 
1 126 GLY n 
1 127 ARG n 
1 128 ARG n 
1 129 THR n 
1 130 SER n 
1 131 ARG n 
1 132 ARG n 
1 133 LYS n 
1 134 ARG n 
1 135 ALA n 
1 136 LYS n 
1 137 VAL n 
1 138 GLU n 
1 139 TYR n 
1 140 ARG n 
1 141 GLU n 
1 142 MET n 
1 143 ASP n 
1 144 GLU n 
1 145 SER n 
1 146 LEU n 
1 147 ALA n 
1 148 ASN n 
1 149 LEU n 
1 150 SER n 
1 151 GLU n 
1 152 ASP n 
1 153 GLU n 
1 154 TYR n 
1 155 TYR n 
1 156 SER n 
1 157 GLU n 
1 158 GLU n 
1 159 GLU n 
1 160 ARG n 
1 161 ASN n 
1 162 ALA n 
1 163 LYS n 
1 164 ALA n 
1 165 GLU n 
1 166 LYS n 
1 167 GLU n 
1 168 LYS n 
1 169 LYS n 
1 170 LEU n 
1 171 PRO n 
1 172 PRO n 
1 173 PRO n 
1 174 PRO n 
1 175 PRO n 
1 176 GLN n 
1 177 ALA n 
1 178 PRO n 
1 179 PRO n 
1 180 GLU n 
1 181 GLU n 
1 182 GLU n 
1 183 ASN n 
1 184 GLU n 
1 185 SER n 
1 186 GLU n 
1 187 PRO n 
1 188 GLU n 
1 189 GLU n 
1 190 PRO n 
1 191 SER n 
1 192 GLY n 
1 193 VAL n 
1 194 GLU n 
1 195 GLY n 
1 196 ALA n 
1 197 ALA n 
1 198 PHE n 
1 199 GLN n 
1 200 SER n 
1 201 ARG n 
1 202 LEU n 
1 203 PRO n 
1 204 HIS n 
1 205 ASP n 
1 206 ARG n 
1 207 MET n 
1 208 THR n 
1 209 SER n 
1 210 GLN n 
1 211 GLU n 
1 212 ALA n 
1 213 ALA n 
1 214 CYS n 
1 215 PHE n 
1 216 PRO n 
1 217 ASP n 
1 218 ILE n 
1 219 ILE n 
1 220 SER n 
1 221 GLY n 
1 222 PRO n 
1 223 GLN n 
1 224 GLN n 
1 225 THR n 
1 226 GLN n 
1 227 LYS n 
1 228 VAL n 
1 229 PHE n 
1 230 LEU n 
1 231 PHE n 
1 232 ILE n 
1 233 ARG n 
1 234 ASN n 
1 235 ARG n 
1 236 THR n 
1 237 LEU n 
1 238 GLN n 
1 239 LEU n 
1 240 TRP n 
1 241 LEU n 
1 242 ASP n 
1 243 ASN n 
1 244 PRO n 
1 245 LYS n 
1 246 ILE n 
1 247 GLN n 
1 248 LEU n 
1 249 THR n 
1 250 PHE n 
1 251 GLU n 
1 252 ALA n 
1 253 THR n 
1 254 LEU n 
1 255 GLN n 
1 256 GLN n 
1 257 LEU n 
1 258 GLU n 
1 259 ALA n 
1 260 PRO n 
1 261 TYR n 
1 262 ASN n 
1 263 SER n 
1 264 ASP n 
1 265 THR n 
1 266 VAL n 
1 267 LEU n 
1 268 VAL n 
1 269 HIS n 
1 270 ARG n 
1 271 VAL n 
1 272 HIS n 
1 273 SER n 
1 274 TYR n 
1 275 LEU n 
1 276 GLU n 
1 277 ARG n 
1 278 HIS n 
1 279 GLY n 
1 280 LEU n 
1 281 ILE n 
1 282 ASN n 
1 283 PHE n 
1 284 GLY n 
1 285 ILE n 
1 286 TYR n 
1 287 LYS n 
1 288 ARG n 
1 289 ILE n 
1 290 LYS n 
1 291 PRO n 
1 292 LEU n 
1 293 PRO n 
1 294 THR n 
1 295 LYS n 
1 296 LYS n 
1 297 THR n 
1 298 GLY n 
1 299 LYS n 
1 300 VAL n 
1 301 ILE n 
1 302 ILE n 
1 303 ILE n 
1 304 GLY n 
1 305 SER n 
1 306 GLY n 
1 307 VAL n 
1 308 SER n 
1 309 GLY n 
1 310 LEU n 
1 311 ALA n 
1 312 ALA n 
1 313 ALA n 
1 314 ARG n 
1 315 GLN n 
1 316 LEU n 
1 317 GLN n 
1 318 SER n 
1 319 PHE n 
1 320 GLY n 
1 321 MET n 
1 322 ASP n 
1 323 VAL n 
1 324 THR n 
1 325 LEU n 
1 326 LEU n 
1 327 GLU n 
1 328 ALA n 
1 329 ARG n 
1 330 ASP n 
1 331 ARG n 
1 332 VAL n 
1 333 GLY n 
1 334 GLY n 
1 335 ARG n 
1 336 VAL n 
1 337 ALA n 
1 338 THR n 
1 339 PHE n 
1 340 ARG n 
1 341 LYS n 
1 342 GLY n 
1 343 ASN n 
1 344 TYR n 
1 345 VAL n 
1 346 ALA n 
1 347 ASP n 
1 348 LEU n 
1 349 GLY n 
1 350 ALA n 
1 351 MET n 
1 352 VAL n 
1 353 VAL n 
1 354 THR n 
1 355 GLY n 
1 356 LEU n 
1 357 GLY n 
1 358 GLY n 
1 359 ASN n 
1 360 PRO n 
1 361 MET n 
1 362 ALA n 
1 363 VAL n 
1 364 VAL n 
1 365 SER n 
1 366 LYS n 
1 367 GLN n 
1 368 VAL n 
1 369 ASN n 
1 370 MET n 
1 371 GLU n 
1 372 LEU n 
1 373 ALA n 
1 374 LYS n 
1 375 ILE n 
1 376 LYS n 
1 377 GLN n 
1 378 LYS n 
1 379 CYS n 
1 380 PRO n 
1 381 LEU n 
1 382 TYR n 
1 383 GLU n 
1 384 ALA n 
1 385 ASN n 
1 386 GLY n 
1 387 GLN n 
1 388 ALA n 
1 389 VAL n 
1 390 PRO n 
1 391 LYS n 
1 392 GLU n 
1 393 LYS n 
1 394 ASP n 
1 395 GLU n 
1 396 MET n 
1 397 VAL n 
1 398 GLU n 
1 399 GLN n 
1 400 GLU n 
1 401 PHE n 
1 402 ASN n 
1 403 ARG n 
1 404 LEU n 
1 405 LEU n 
1 406 GLU n 
1 407 ALA n 
1 408 THR n 
1 409 SER n 
1 410 TYR n 
1 411 LEU n 
1 412 SER n 
1 413 HIS n 
1 414 GLN n 
1 415 LEU n 
1 416 ASP n 
1 417 PHE n 
1 418 ASN n 
1 419 VAL n 
1 420 LEU n 
1 421 ASN n 
1 422 ASN n 
1 423 LYS n 
1 424 PRO n 
1 425 VAL n 
1 426 SER n 
1 427 LEU n 
1 428 GLY n 
1 429 GLN n 
1 430 ALA n 
1 431 LEU n 
1 432 GLU n 
1 433 VAL n 
1 434 VAL n 
1 435 ILE n 
1 436 GLN n 
1 437 LEU n 
1 438 GLN n 
1 439 GLU n 
1 440 LYS n 
1 441 HIS n 
1 442 VAL n 
1 443 LYS n 
1 444 ASP n 
1 445 GLU n 
1 446 GLN n 
1 447 ILE n 
1 448 GLU n 
1 449 HIS n 
1 450 TRP n 
1 451 LYS n 
1 452 LYS n 
1 453 ILE n 
1 454 VAL n 
1 455 LYS n 
1 456 THR n 
1 457 GLN n 
1 458 GLU n 
1 459 GLU n 
1 460 LEU n 
1 461 LYS n 
1 462 GLU n 
1 463 LEU n 
1 464 LEU n 
1 465 ASN n 
1 466 LYS n 
1 467 MET n 
1 468 VAL n 
1 469 ASN n 
1 470 LEU n 
1 471 LYS n 
1 472 GLU n 
1 473 LYS n 
1 474 ILE n 
1 475 LYS n 
1 476 GLU n 
1 477 LEU n 
1 478 HIS n 
1 479 GLN n 
1 480 GLN n 
1 481 TYR n 
1 482 LYS n 
1 483 GLU n 
1 484 ALA n 
1 485 SER n 
1 486 GLU n 
1 487 VAL n 
1 488 LYS n 
1 489 PRO n 
1 490 PRO n 
1 491 ARG n 
1 492 ASP n 
1 493 ILE n 
1 494 THR n 
1 495 ALA n 
1 496 GLU n 
1 497 PHE n 
1 498 LEU n 
1 499 VAL n 
1 500 LYS n 
1 501 SER n 
1 502 LYS n 
1 503 HIS n 
1 504 ARG n 
1 505 ASP n 
1 506 LEU n 
1 507 THR n 
1 508 ALA n 
1 509 LEU n 
1 510 CYS n 
1 511 LYS n 
1 512 GLU n 
1 513 TYR n 
1 514 ASP n 
1 515 GLU n 
1 516 LEU n 
1 517 ALA n 
1 518 GLU n 
1 519 THR n 
1 520 GLN n 
1 521 GLY n 
1 522 LYS n 
1 523 LEU n 
1 524 GLU n 
1 525 GLU n 
1 526 LYS n 
1 527 LEU n 
1 528 GLN n 
1 529 GLU n 
1 530 LEU n 
1 531 GLU n 
1 532 ALA n 
1 533 ASN n 
1 534 PRO n 
1 535 PRO n 
1 536 SER n 
1 537 ASP n 
1 538 VAL n 
1 539 TYR n 
1 540 LEU n 
1 541 SER n 
1 542 SER n 
1 543 ARG n 
1 544 ASP n 
1 545 ARG n 
1 546 GLN n 
1 547 ILE n 
1 548 LEU n 
1 549 ASP n 
1 550 TRP n 
1 551 HIS n 
1 552 PHE n 
1 553 ALA n 
1 554 ASN n 
1 555 LEU n 
1 556 GLU n 
1 557 PHE n 
1 558 ALA n 
1 559 ASN n 
1 560 ALA n 
1 561 THR n 
1 562 PRO n 
1 563 LEU n 
1 564 SER n 
1 565 THR n 
1 566 LEU n 
1 567 SER n 
1 568 LEU n 
1 569 LYS n 
1 570 HIS n 
1 571 TRP n 
1 572 ASP n 
1 573 GLN n 
1 574 ASP n 
1 575 ASP n 
1 576 ASP n 
1 577 PHE n 
1 578 GLU n 
1 579 PHE n 
1 580 THR n 
1 581 GLY n 
1 582 SER n 
1 583 HIS n 
1 584 LEU n 
1 585 THR n 
1 586 VAL n 
1 587 ARG n 
1 588 ASN n 
1 589 GLY n 
1 590 TYR n 
1 591 SER n 
1 592 CYS n 
1 593 VAL n 
1 594 PRO n 
1 595 VAL n 
1 596 ALA n 
1 597 LEU n 
1 598 ALA n 
1 599 GLU n 
1 600 GLY n 
1 601 LEU n 
1 602 ASP n 
1 603 ILE n 
1 604 LYS n 
1 605 LEU n 
1 606 ASN n 
1 607 THR n 
1 608 ALA n 
1 609 VAL n 
1 610 ARG n 
1 611 GLN n 
1 612 VAL n 
1 613 ARG n 
1 614 TYR n 
1 615 THR n 
1 616 ALA n 
1 617 SER n 
1 618 GLY n 
1 619 CYS n 
1 620 GLU n 
1 621 VAL n 
1 622 ILE n 
1 623 ALA n 
1 624 VAL n 
1 625 ASN n 
1 626 THR n 
1 627 ARG n 
1 628 SER n 
1 629 THR n 
1 630 SER n 
1 631 GLN n 
1 632 THR n 
1 633 PHE n 
1 634 ILE n 
1 635 TYR n 
1 636 LYS n 
1 637 CYS n 
1 638 ASP n 
1 639 ALA n 
1 640 VAL n 
1 641 LEU n 
1 642 CYS n 
1 643 THR n 
1 644 LEU n 
1 645 PRO n 
1 646 LEU n 
1 647 GLY n 
1 648 VAL n 
1 649 LEU n 
1 650 LYS n 
1 651 GLN n 
1 652 GLN n 
1 653 PRO n 
1 654 PRO n 
1 655 ALA n 
1 656 VAL n 
1 657 GLN n 
1 658 PHE n 
1 659 VAL n 
1 660 PRO n 
1 661 PRO n 
1 662 LEU n 
1 663 PRO n 
1 664 GLU n 
1 665 TRP n 
1 666 LYS n 
1 667 THR n 
1 668 SER n 
1 669 ALA n 
1 670 VAL n 
1 671 GLN n 
1 672 ARG n 
1 673 MET n 
1 674 GLY n 
1 675 PHE n 
1 676 GLY n 
1 677 ASN n 
1 678 LEU n 
1 679 ASN n 
1 680 LYS n 
1 681 VAL n 
1 682 VAL n 
1 683 LEU n 
1 684 CYS n 
1 685 PHE n 
1 686 ASP n 
1 687 ARG n 
1 688 VAL n 
1 689 PHE n 
1 690 TRP n 
1 691 ASP n 
1 692 PRO n 
1 693 SER n 
1 694 VAL n 
1 695 ASN n 
1 696 LEU n 
1 697 PHE n 
1 698 GLY n 
1 699 HIS n 
1 700 VAL n 
1 701 GLY n 
1 702 SER n 
1 703 THR n 
1 704 THR n 
1 705 ALA n 
1 706 SER n 
1 707 ARG n 
1 708 GLY n 
1 709 GLU n 
1 710 LEU n 
1 711 PHE n 
1 712 LEU n 
1 713 PHE n 
1 714 TRP n 
1 715 ASN n 
1 716 LEU n 
1 717 TYR n 
1 718 LYS n 
1 719 ALA n 
1 720 PRO n 
1 721 ILE n 
1 722 LEU n 
1 723 LEU n 
1 724 ALA n 
1 725 LEU n 
1 726 VAL n 
1 727 ALA n 
1 728 GLY n 
1 729 GLU n 
1 730 ALA n 
1 731 ALA n 
1 732 GLY n 
1 733 ILE n 
1 734 MET n 
1 735 GLU n 
1 736 ASN n 
1 737 ILE n 
1 738 SER n 
1 739 ASP n 
1 740 ASP n 
1 741 VAL n 
1 742 ILE n 
1 743 VAL n 
1 744 GLY n 
1 745 ARG n 
1 746 CYS n 
1 747 LEU n 
1 748 ALA n 
1 749 ILE n 
1 750 LEU n 
1 751 LYS n 
1 752 GLY n 
1 753 ILE n 
1 754 PHE n 
1 755 GLY n 
1 756 SER n 
1 757 SER n 
1 758 ALA n 
1 759 VAL n 
1 760 PRO n 
1 761 GLN n 
1 762 PRO n 
1 763 LYS n 
1 764 GLU n 
1 765 THR n 
1 766 VAL n 
1 767 VAL n 
1 768 SER n 
1 769 ARG n 
1 770 TRP n 
1 771 ARG n 
1 772 ALA n 
1 773 ASP n 
1 774 PRO n 
1 775 TRP n 
1 776 ALA n 
1 777 ARG n 
1 778 GLY n 
1 779 SER n 
1 780 TYR n 
1 781 SER n 
1 782 TYR n 
1 783 VAL n 
1 784 ALA n 
1 785 ALA n 
1 786 GLY n 
1 787 SER n 
1 788 SER n 
1 789 GLY n 
1 790 ASN n 
1 791 ASP n 
1 792 TYR n 
1 793 ASP n 
1 794 LEU n 
1 795 MET n 
1 796 ALA n 
1 797 GLN n 
1 798 PRO n 
1 799 ILE n 
1 800 THR n 
1 801 PRO n 
1 802 GLY n 
1 803 PRO n 
1 804 SER n 
1 805 ILE n 
1 806 PRO n 
1 807 GLY n 
1 808 ALA n 
1 809 PRO n 
1 810 GLN n 
1 811 PRO n 
1 812 ILE n 
1 813 PRO n 
1 814 ARG n 
1 815 LEU n 
1 816 PHE n 
1 817 PHE n 
1 818 ALA n 
1 819 GLY n 
1 820 GLU n 
1 821 HIS n 
1 822 THR n 
1 823 ILE n 
1 824 ARG n 
1 825 ASN n 
1 826 TYR n 
1 827 PRO n 
1 828 ALA n 
1 829 THR n 
1 830 VAL n 
1 831 HIS n 
1 832 GLY n 
1 833 ALA n 
1 834 LEU n 
1 835 LEU n 
1 836 SER n 
1 837 GLY n 
1 838 LEU n 
1 839 ARG n 
1 840 GLU n 
1 841 ALA n 
1 842 GLY n 
1 843 ARG n 
1 844 ILE n 
1 845 ALA n 
1 846 ASP n 
1 847 GLN n 
1 848 PHE n 
1 849 LEU n 
1 850 GLY n 
1 851 ALA n 
1 852 MET n 
1 853 TYR n 
1 854 THR n 
1 855 LEU n 
1 856 PRO n 
1 857 ARG n 
1 858 GLN n 
1 859 ALA n 
1 860 THR n 
1 861 PRO n 
1 862 GLY n 
1 863 VAL n 
1 864 PRO n 
1 865 ALA n 
1 866 GLN n 
1 867 GLN n 
1 868 SER n 
1 869 PRO n 
1 870 SER n 
1 871 MET n 
2 1   GLY n 
2 2   PRO n 
2 3   LEU n 
2 4   GLY n 
2 5   SER n 
2 6   PRO n 
2 7   GLU n 
2 8   PHE n 
2 9   ARG n 
2 10  ALA n 
2 11  LYS n 
2 12  ARG n 
2 13  LYS n 
2 14  PRO n 
2 15  PRO n 
2 16  LYS n 
2 17  GLY n 
2 18  MET n 
2 19  PHE n 
2 20  LEU n 
2 21  SER n 
2 22  GLN n 
2 23  GLU n 
2 24  ASP n 
2 25  VAL n 
2 26  GLU n 
2 27  ALA n 
2 28  VAL n 
2 29  SER n 
2 30  ALA n 
2 31  ASN n 
2 32  ALA n 
2 33  THR n 
2 34  ALA n 
2 35  ALA n 
2 36  THR n 
2 37  THR n 
2 38  VAL n 
2 39  LEU n 
2 40  ARG n 
2 41  GLN n 
2 42  LEU n 
2 43  ASP n 
2 44  MET n 
2 45  GLU n 
2 46  LEU n 
2 47  VAL n 
2 48  SER n 
2 49  VAL n 
2 50  LYS n 
2 51  ARG n 
2 52  GLN n 
2 53  ILE n 
2 54  GLN n 
2 55  ASN n 
2 56  ILE n 
2 57  LYS n 
2 58  GLN n 
2 59  THR n 
2 60  ASN n 
2 61  SER n 
2 62  ALA n 
2 63  LEU n 
2 64  LYS n 
2 65  GLU n 
2 66  LYS n 
2 67  LEU n 
2 68  ASP n 
2 69  GLY n 
2 70  GLY n 
2 71  ILE n 
2 72  GLU n 
2 73  PRO n 
2 74  TYR n 
2 75  ARG n 
2 76  LEU n 
2 77  PRO n 
2 78  GLU n 
2 79  VAL n 
2 80  ILE n 
2 81  GLN n 
2 82  LYS n 
2 83  CYS n 
2 84  ASN n 
2 85  ALA n 
2 86  ARG n 
2 87  TRP n 
2 88  THR n 
2 89  THR n 
2 90  GLU n 
2 91  GLU n 
2 92  GLN n 
2 93  LEU n 
2 94  LEU n 
2 95  ALA n 
2 96  VAL n 
2 97  GLN n 
2 98  ALA n 
2 99  ILE n 
2 100 ARG n 
2 101 LYS n 
2 102 TYR n 
2 103 GLY n 
2 104 ARG n 
2 105 ASP n 
2 106 PHE n 
2 107 GLN n 
2 108 ALA n 
2 109 ILE n 
2 110 SER n 
2 111 ASP n 
2 112 VAL n 
2 113 ILE n 
2 114 GLY n 
2 115 ASN n 
2 116 LYS n 
2 117 SER n 
2 118 VAL n 
2 119 VAL n 
2 120 GLN n 
2 121 VAL n 
2 122 LYS n 
2 123 ASN n 
2 124 PHE n 
2 125 PHE n 
2 126 VAL n 
2 127 ASN n 
2 128 TYR n 
2 129 ARG n 
2 130 ARG n 
2 131 ARG n 
2 132 PHE n 
2 133 ASN n 
2 134 ILE n 
2 135 ASP n 
2 136 GLU n 
2 137 VAL n 
2 138 LEU n 
2 139 GLN n 
2 140 GLU n 
2 141 TRP n 
2 142 GLU n 
2 143 ALA n 
2 144 GLU n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 871 human ? 'KDM1A, AOF2, KDM1, KIAA0601, LSD1' ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 
'Escherichia coli' 562 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 144 human ? 'RCOR1, KIAA0071, RCOR'             ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 
'Escherichia coli' 562 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2'         89.093  
ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1'     175.209 
ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'        132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'         133.103 
CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'       121.158 
GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'       146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'         147.129 
GLY 'peptide linking'   y GLYCINE ? 'C2 H5 N O2'         75.067  
HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1'     156.162 
ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'        131.173 
K   non-polymer         . 'POTASSIUM ION' ? 'K 1'                39.098  
LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'        131.173 
LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1'     147.195 
MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'      149.211 
PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'        165.189 
PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2'         115.130 
SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3'         105.093 
THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3'         119.119 
TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2'      204.225 
TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'        181.189 
VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2'        117.146 
ZSI non-polymer         . 
;[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl (2R,3S,4S)-2,3,4-trihydroxy-5-[(1R,3S,3aS,13R)-1-hydroxy-10,11-dimethyl-3-[3-(methylcarbamoyl)phenyl]-4,6-dioxo-2,3,5,6-tetrahydro-1H-benzo[g]pyrrolo[2,1-e]pteridin-8(4H)-yl]pentyl dihydrogen diphosphate (non-preferred name)
;
? 'C38 H46 N10 O17 P2' 976.776 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   -18 ?   ?   ?   A . n 
A 1 2   SER 2   -17 ?   ?   ?   A . n 
A 1 3   SER 3   -16 ?   ?   ?   A . n 
A 1 4   HIS 4   -15 ?   ?   ?   A . n 
A 1 5   HIS 5   -14 ?   ?   ?   A . n 
A 1 6   HIS 6   -13 ?   ?   ?   A . n 
A 1 7   HIS 7   -12 ?   ?   ?   A . n 
A 1 8   HIS 8   -11 ?   ?   ?   A . n 
A 1 9   HIS 9   -10 ?   ?   ?   A . n 
A 1 10  SER 10  -9  ?   ?   ?   A . n 
A 1 11  SER 11  -8  ?   ?   ?   A . n 
A 1 12  GLY 12  -7  ?   ?   ?   A . n 
A 1 13  LEU 13  -6  ?   ?   ?   A . n 
A 1 14  VAL 14  -5  ?   ?   ?   A . n 
A 1 15  PRO 15  -4  ?   ?   ?   A . n 
A 1 16  ARG 16  -3  ?   ?   ?   A . n 
A 1 17  GLY 17  -2  ?   ?   ?   A . n 
A 1 18  SER 18  -1  ?   ?   ?   A . n 
A 1 19  HIS 19  0   ?   ?   ?   A . n 
A 1 20  MET 20  1   ?   ?   ?   A . n 
A 1 21  LEU 21  2   ?   ?   ?   A . n 
A 1 22  SER 22  3   ?   ?   ?   A . n 
A 1 23  GLY 23  4   ?   ?   ?   A . n 
A 1 24  LYS 24  5   ?   ?   ?   A . n 
A 1 25  LYS 25  6   ?   ?   ?   A . n 
A 1 26  ALA 26  7   ?   ?   ?   A . n 
A 1 27  ALA 27  8   ?   ?   ?   A . n 
A 1 28  ALA 28  9   ?   ?   ?   A . n 
A 1 29  ALA 29  10  ?   ?   ?   A . n 
A 1 30  ALA 30  11  ?   ?   ?   A . n 
A 1 31  ALA 31  12  ?   ?   ?   A . n 
A 1 32  ALA 32  13  ?   ?   ?   A . n 
A 1 33  ALA 33  14  ?   ?   ?   A . n 
A 1 34  ALA 34  15  ?   ?   ?   A . n 
A 1 35  ALA 35  16  ?   ?   ?   A . n 
A 1 36  ALA 36  17  ?   ?   ?   A . n 
A 1 37  ALA 37  18  ?   ?   ?   A . n 
A 1 38  THR 38  19  ?   ?   ?   A . n 
A 1 39  GLY 39  20  ?   ?   ?   A . n 
A 1 40  THR 40  21  ?   ?   ?   A . n 
A 1 41  GLU 41  22  ?   ?   ?   A . n 
A 1 42  ALA 42  23  ?   ?   ?   A . n 
A 1 43  GLY 43  24  ?   ?   ?   A . n 
A 1 44  PRO 44  25  ?   ?   ?   A . n 
A 1 45  GLY 45  26  ?   ?   ?   A . n 
A 1 46  THR 46  27  ?   ?   ?   A . n 
A 1 47  ALA 47  28  ?   ?   ?   A . n 
A 1 48  GLY 48  29  ?   ?   ?   A . n 
A 1 49  GLY 49  30  ?   ?   ?   A . n 
A 1 50  SER 50  31  ?   ?   ?   A . n 
A 1 51  GLU 51  32  ?   ?   ?   A . n 
A 1 52  ASN 52  33  ?   ?   ?   A . n 
A 1 53  GLY 53  34  ?   ?   ?   A . n 
A 1 54  SER 54  35  ?   ?   ?   A . n 
A 1 55  GLU 55  36  ?   ?   ?   A . n 
A 1 56  VAL 56  37  ?   ?   ?   A . n 
A 1 57  ALA 57  38  ?   ?   ?   A . n 
A 1 58  ALA 58  39  ?   ?   ?   A . n 
A 1 59  GLN 59  40  ?   ?   ?   A . n 
A 1 60  PRO 60  41  ?   ?   ?   A . n 
A 1 61  ALA 61  42  ?   ?   ?   A . n 
A 1 62  GLY 62  43  ?   ?   ?   A . n 
A 1 63  LEU 63  44  ?   ?   ?   A . n 
A 1 64  SER 64  45  ?   ?   ?   A . n 
A 1 65  GLY 65  46  ?   ?   ?   A . n 
A 1 66  PRO 66  47  ?   ?   ?   A . n 
A 1 67  ALA 67  48  ?   ?   ?   A . n 
A 1 68  GLU 68  49  ?   ?   ?   A . n 
A 1 69  VAL 69  50  ?   ?   ?   A . n 
A 1 70  GLY 70  51  ?   ?   ?   A . n 
A 1 71  PRO 71  52  ?   ?   ?   A . n 
A 1 72  GLY 72  53  ?   ?   ?   A . n 
A 1 73  ALA 73  54  ?   ?   ?   A . n 
A 1 74  VAL 74  55  ?   ?   ?   A . n 
A 1 75  GLY 75  56  ?   ?   ?   A . n 
A 1 76  GLU 76  57  ?   ?   ?   A . n 
A 1 77  ARG 77  58  ?   ?   ?   A . n 
A 1 78  THR 78  59  ?   ?   ?   A . n 
A 1 79  PRO 79  60  ?   ?   ?   A . n 
A 1 80  ARG 80  61  ?   ?   ?   A . n 
A 1 81  LYS 81  62  ?   ?   ?   A . n 
A 1 82  LYS 82  63  ?   ?   ?   A . n 
A 1 83  GLU 83  64  ?   ?   ?   A . n 
A 1 84  PRO 84  65  ?   ?   ?   A . n 
A 1 85  PRO 85  66  ?   ?   ?   A . n 
A 1 86  ARG 86  67  ?   ?   ?   A . n 
A 1 87  ALA 87  68  ?   ?   ?   A . n 
A 1 88  SER 88  69  ?   ?   ?   A . n 
A 1 89  PRO 89  70  ?   ?   ?   A . n 
A 1 90  PRO 90  71  ?   ?   ?   A . n 
A 1 91  GLY 91  72  ?   ?   ?   A . n 
A 1 92  GLY 92  73  ?   ?   ?   A . n 
A 1 93  LEU 93  74  ?   ?   ?   A . n 
A 1 94  ALA 94  75  ?   ?   ?   A . n 
A 1 95  GLU 95  76  ?   ?   ?   A . n 
A 1 96  PRO 96  77  ?   ?   ?   A . n 
A 1 97  PRO 97  78  ?   ?   ?   A . n 
A 1 98  GLY 98  79  ?   ?   ?   A . n 
A 1 99  SER 99  80  ?   ?   ?   A . n 
A 1 100 ALA 100 81  ?   ?   ?   A . n 
A 1 101 GLY 101 82  ?   ?   ?   A . n 
A 1 102 PRO 102 83  ?   ?   ?   A . n 
A 1 103 GLN 103 84  ?   ?   ?   A . n 
A 1 104 ALA 104 85  ?   ?   ?   A . n 
A 1 105 GLY 105 86  ?   ?   ?   A . n 
A 1 106 PRO 106 87  ?   ?   ?   A . n 
A 1 107 THR 107 88  ?   ?   ?   A . n 
A 1 108 VAL 108 89  ?   ?   ?   A . n 
A 1 109 VAL 109 90  ?   ?   ?   A . n 
A 1 110 PRO 110 91  ?   ?   ?   A . n 
A 1 111 GLY 111 92  ?   ?   ?   A . n 
A 1 112 SER 112 93  ?   ?   ?   A . n 
A 1 113 ALA 113 94  ?   ?   ?   A . n 
A 1 114 THR 114 95  ?   ?   ?   A . n 
A 1 115 PRO 115 96  ?   ?   ?   A . n 
A 1 116 MET 116 97  ?   ?   ?   A . n 
A 1 117 GLU 117 98  ?   ?   ?   A . n 
A 1 118 THR 118 99  ?   ?   ?   A . n 
A 1 119 GLY 119 100 ?   ?   ?   A . n 
A 1 120 ILE 120 101 ?   ?   ?   A . n 
A 1 121 ALA 121 102 ?   ?   ?   A . n 
A 1 122 GLU 122 103 ?   ?   ?   A . n 
A 1 123 THR 123 104 ?   ?   ?   A . n 
A 1 124 PRO 124 105 ?   ?   ?   A . n 
A 1 125 GLU 125 106 ?   ?   ?   A . n 
A 1 126 GLY 126 107 ?   ?   ?   A . n 
A 1 127 ARG 127 108 ?   ?   ?   A . n 
A 1 128 ARG 128 109 ?   ?   ?   A . n 
A 1 129 THR 129 110 ?   ?   ?   A . n 
A 1 130 SER 130 111 ?   ?   ?   A . n 
A 1 131 ARG 131 112 ?   ?   ?   A . n 
A 1 132 ARG 132 113 ?   ?   ?   A . n 
A 1 133 LYS 133 114 ?   ?   ?   A . n 
A 1 134 ARG 134 115 ?   ?   ?   A . n 
A 1 135 ALA 135 116 ?   ?   ?   A . n 
A 1 136 LYS 136 117 ?   ?   ?   A . n 
A 1 137 VAL 137 118 ?   ?   ?   A . n 
A 1 138 GLU 138 119 ?   ?   ?   A . n 
A 1 139 TYR 139 120 ?   ?   ?   A . n 
A 1 140 ARG 140 121 ?   ?   ?   A . n 
A 1 141 GLU 141 122 ?   ?   ?   A . n 
A 1 142 MET 142 123 ?   ?   ?   A . n 
A 1 143 ASP 143 124 ?   ?   ?   A . n 
A 1 144 GLU 144 125 ?   ?   ?   A . n 
A 1 145 SER 145 126 ?   ?   ?   A . n 
A 1 146 LEU 146 127 ?   ?   ?   A . n 
A 1 147 ALA 147 128 ?   ?   ?   A . n 
A 1 148 ASN 148 129 ?   ?   ?   A . n 
A 1 149 LEU 149 130 ?   ?   ?   A . n 
A 1 150 SER 150 131 ?   ?   ?   A . n 
A 1 151 GLU 151 132 ?   ?   ?   A . n 
A 1 152 ASP 152 133 ?   ?   ?   A . n 
A 1 153 GLU 153 134 ?   ?   ?   A . n 
A 1 154 TYR 154 135 ?   ?   ?   A . n 
A 1 155 TYR 155 136 ?   ?   ?   A . n 
A 1 156 SER 156 137 ?   ?   ?   A . n 
A 1 157 GLU 157 138 ?   ?   ?   A . n 
A 1 158 GLU 158 139 ?   ?   ?   A . n 
A 1 159 GLU 159 140 ?   ?   ?   A . n 
A 1 160 ARG 160 141 ?   ?   ?   A . n 
A 1 161 ASN 161 142 ?   ?   ?   A . n 
A 1 162 ALA 162 143 ?   ?   ?   A . n 
A 1 163 LYS 163 144 ?   ?   ?   A . n 
A 1 164 ALA 164 145 ?   ?   ?   A . n 
A 1 165 GLU 165 146 ?   ?   ?   A . n 
A 1 166 LYS 166 147 ?   ?   ?   A . n 
A 1 167 GLU 167 148 ?   ?   ?   A . n 
A 1 168 LYS 168 149 ?   ?   ?   A . n 
A 1 169 LYS 169 150 ?   ?   ?   A . n 
A 1 170 LEU 170 151 ?   ?   ?   A . n 
A 1 171 PRO 171 152 ?   ?   ?   A . n 
A 1 172 PRO 172 153 ?   ?   ?   A . n 
A 1 173 PRO 173 154 ?   ?   ?   A . n 
A 1 174 PRO 174 155 ?   ?   ?   A . n 
A 1 175 PRO 175 156 ?   ?   ?   A . n 
A 1 176 GLN 176 157 ?   ?   ?   A . n 
A 1 177 ALA 177 158 ?   ?   ?   A . n 
A 1 178 PRO 178 159 ?   ?   ?   A . n 
A 1 179 PRO 179 160 ?   ?   ?   A . n 
A 1 180 GLU 180 161 ?   ?   ?   A . n 
A 1 181 GLU 181 162 ?   ?   ?   A . n 
A 1 182 GLU 182 163 ?   ?   ?   A . n 
A 1 183 ASN 183 164 ?   ?   ?   A . n 
A 1 184 GLU 184 165 ?   ?   ?   A . n 
A 1 185 SER 185 166 ?   ?   ?   A . n 
A 1 186 GLU 186 167 ?   ?   ?   A . n 
A 1 187 PRO 187 168 ?   ?   ?   A . n 
A 1 188 GLU 188 169 ?   ?   ?   A . n 
A 1 189 GLU 189 170 ?   ?   ?   A . n 
A 1 190 PRO 190 171 171 PRO PRO A . n 
A 1 191 SER 191 172 172 SER SER A . n 
A 1 192 GLY 192 173 173 GLY GLY A . n 
A 1 193 VAL 193 174 174 VAL VAL A . n 
A 1 194 GLU 194 175 175 GLU GLU A . n 
A 1 195 GLY 195 176 176 GLY GLY A . n 
A 1 196 ALA 196 177 177 ALA ALA A . n 
A 1 197 ALA 197 178 178 ALA ALA A . n 
A 1 198 PHE 198 179 179 PHE PHE A . n 
A 1 199 GLN 199 180 180 GLN GLN A . n 
A 1 200 SER 200 181 181 SER SER A . n 
A 1 201 ARG 201 182 182 ARG ARG A . n 
A 1 202 LEU 202 183 183 LEU LEU A . n 
A 1 203 PRO 203 184 184 PRO PRO A . n 
A 1 204 HIS 204 185 185 HIS HIS A . n 
A 1 205 ASP 205 186 186 ASP ASP A . n 
A 1 206 ARG 206 187 187 ARG ARG A . n 
A 1 207 MET 207 188 188 MET MET A . n 
A 1 208 THR 208 189 189 THR THR A . n 
A 1 209 SER 209 190 190 SER SER A . n 
A 1 210 GLN 210 191 191 GLN GLN A . n 
A 1 211 GLU 211 192 192 GLU GLU A . n 
A 1 212 ALA 212 193 193 ALA ALA A . n 
A 1 213 ALA 213 194 194 ALA ALA A . n 
A 1 214 CYS 214 195 195 CYS CYS A . n 
A 1 215 PHE 215 196 196 PHE PHE A . n 
A 1 216 PRO 216 197 197 PRO PRO A . n 
A 1 217 ASP 217 198 198 ASP ASP A . n 
A 1 218 ILE 218 199 199 ILE ILE A . n 
A 1 219 ILE 219 200 200 ILE ILE A . n 
A 1 220 SER 220 201 201 SER SER A . n 
A 1 221 GLY 221 202 202 GLY GLY A . n 
A 1 222 PRO 222 203 203 PRO PRO A . n 
A 1 223 GLN 223 204 204 GLN GLN A . n 
A 1 224 GLN 224 205 205 GLN GLN A . n 
A 1 225 THR 225 206 206 THR THR A . n 
A 1 226 GLN 226 207 207 GLN GLN A . n 
A 1 227 LYS 227 208 208 LYS LYS A . n 
A 1 228 VAL 228 209 209 VAL VAL A . n 
A 1 229 PHE 229 210 210 PHE PHE A . n 
A 1 230 LEU 230 211 211 LEU LEU A . n 
A 1 231 PHE 231 212 212 PHE PHE A . n 
A 1 232 ILE 232 213 213 ILE ILE A . n 
A 1 233 ARG 233 214 214 ARG ARG A . n 
A 1 234 ASN 234 215 215 ASN ASN A . n 
A 1 235 ARG 235 216 216 ARG ARG A . n 
A 1 236 THR 236 217 217 THR THR A . n 
A 1 237 LEU 237 218 218 LEU LEU A . n 
A 1 238 GLN 238 219 219 GLN GLN A . n 
A 1 239 LEU 239 220 220 LEU LEU A . n 
A 1 240 TRP 240 221 221 TRP TRP A . n 
A 1 241 LEU 241 222 222 LEU LEU A . n 
A 1 242 ASP 242 223 223 ASP ASP A . n 
A 1 243 ASN 243 224 224 ASN ASN A . n 
A 1 244 PRO 244 225 225 PRO PRO A . n 
A 1 245 LYS 245 226 226 LYS LYS A . n 
A 1 246 ILE 246 227 227 ILE ILE A . n 
A 1 247 GLN 247 228 228 GLN GLN A . n 
A 1 248 LEU 248 229 229 LEU LEU A . n 
A 1 249 THR 249 230 230 THR THR A . n 
A 1 250 PHE 250 231 231 PHE PHE A . n 
A 1 251 GLU 251 232 232 GLU GLU A . n 
A 1 252 ALA 252 233 233 ALA ALA A . n 
A 1 253 THR 253 234 234 THR THR A . n 
A 1 254 LEU 254 235 235 LEU LEU A . n 
A 1 255 GLN 255 236 236 GLN GLN A . n 
A 1 256 GLN 256 237 237 GLN GLN A . n 
A 1 257 LEU 257 238 238 LEU LEU A . n 
A 1 258 GLU 258 239 239 GLU GLU A . n 
A 1 259 ALA 259 240 240 ALA ALA A . n 
A 1 260 PRO 260 241 241 PRO PRO A . n 
A 1 261 TYR 261 242 242 TYR TYR A . n 
A 1 262 ASN 262 243 243 ASN ASN A . n 
A 1 263 SER 263 244 244 SER SER A . n 
A 1 264 ASP 264 245 245 ASP ASP A . n 
A 1 265 THR 265 246 246 THR THR A . n 
A 1 266 VAL 266 247 247 VAL VAL A . n 
A 1 267 LEU 267 248 248 LEU LEU A . n 
A 1 268 VAL 268 249 249 VAL VAL A . n 
A 1 269 HIS 269 250 250 HIS HIS A . n 
A 1 270 ARG 270 251 251 ARG ARG A . n 
A 1 271 VAL 271 252 252 VAL VAL A . n 
A 1 272 HIS 272 253 253 HIS HIS A . n 
A 1 273 SER 273 254 254 SER SER A . n 
A 1 274 TYR 274 255 255 TYR TYR A . n 
A 1 275 LEU 275 256 256 LEU LEU A . n 
A 1 276 GLU 276 257 257 GLU GLU A . n 
A 1 277 ARG 277 258 258 ARG ARG A . n 
A 1 278 HIS 278 259 259 HIS HIS A . n 
A 1 279 GLY 279 260 260 GLY GLY A . n 
A 1 280 LEU 280 261 261 LEU LEU A . n 
A 1 281 ILE 281 262 262 ILE ILE A . n 
A 1 282 ASN 282 263 263 ASN ASN A . n 
A 1 283 PHE 283 264 264 PHE PHE A . n 
A 1 284 GLY 284 265 265 GLY GLY A . n 
A 1 285 ILE 285 266 266 ILE ILE A . n 
A 1 286 TYR 286 267 267 TYR TYR A . n 
A 1 287 LYS 287 268 268 LYS LYS A . n 
A 1 288 ARG 288 269 269 ARG ARG A . n 
A 1 289 ILE 289 270 270 ILE ILE A . n 
A 1 290 LYS 290 271 271 LYS LYS A . n 
A 1 291 PRO 291 272 272 PRO PRO A . n 
A 1 292 LEU 292 273 273 LEU LEU A . n 
A 1 293 PRO 293 274 274 PRO PRO A . n 
A 1 294 THR 294 275 275 THR THR A . n 
A 1 295 LYS 295 276 276 LYS LYS A . n 
A 1 296 LYS 296 277 277 LYS LYS A . n 
A 1 297 THR 297 278 278 THR THR A . n 
A 1 298 GLY 298 279 279 GLY GLY A . n 
A 1 299 LYS 299 280 280 LYS LYS A . n 
A 1 300 VAL 300 281 281 VAL VAL A . n 
A 1 301 ILE 301 282 282 ILE ILE A . n 
A 1 302 ILE 302 283 283 ILE ILE A . n 
A 1 303 ILE 303 284 284 ILE ILE A . n 
A 1 304 GLY 304 285 285 GLY GLY A . n 
A 1 305 SER 305 286 286 SER SER A . n 
A 1 306 GLY 306 287 287 GLY GLY A . n 
A 1 307 VAL 307 288 288 VAL VAL A . n 
A 1 308 SER 308 289 289 SER SER A . n 
A 1 309 GLY 309 290 290 GLY GLY A . n 
A 1 310 LEU 310 291 291 LEU LEU A . n 
A 1 311 ALA 311 292 292 ALA ALA A . n 
A 1 312 ALA 312 293 293 ALA ALA A . n 
A 1 313 ALA 313 294 294 ALA ALA A . n 
A 1 314 ARG 314 295 295 ARG ARG A . n 
A 1 315 GLN 315 296 296 GLN GLN A . n 
A 1 316 LEU 316 297 297 LEU LEU A . n 
A 1 317 GLN 317 298 298 GLN GLN A . n 
A 1 318 SER 318 299 299 SER SER A . n 
A 1 319 PHE 319 300 300 PHE PHE A . n 
A 1 320 GLY 320 301 301 GLY GLY A . n 
A 1 321 MET 321 302 302 MET MET A . n 
A 1 322 ASP 322 303 303 ASP ASP A . n 
A 1 323 VAL 323 304 304 VAL VAL A . n 
A 1 324 THR 324 305 305 THR THR A . n 
A 1 325 LEU 325 306 306 LEU LEU A . n 
A 1 326 LEU 326 307 307 LEU LEU A . n 
A 1 327 GLU 327 308 308 GLU GLU A . n 
A 1 328 ALA 328 309 309 ALA ALA A . n 
A 1 329 ARG 329 310 310 ARG ARG A . n 
A 1 330 ASP 330 311 311 ASP ASP A . n 
A 1 331 ARG 331 312 312 ARG ARG A . n 
A 1 332 VAL 332 313 313 VAL VAL A . n 
A 1 333 GLY 333 314 314 GLY GLY A . n 
A 1 334 GLY 334 315 315 GLY GLY A . n 
A 1 335 ARG 335 316 316 ARG ARG A . n 
A 1 336 VAL 336 317 317 VAL VAL A . n 
A 1 337 ALA 337 318 318 ALA ALA A . n 
A 1 338 THR 338 319 319 THR THR A . n 
A 1 339 PHE 339 320 320 PHE PHE A . n 
A 1 340 ARG 340 321 321 ARG ARG A . n 
A 1 341 LYS 341 322 322 LYS LYS A . n 
A 1 342 GLY 342 323 323 GLY GLY A . n 
A 1 343 ASN 343 324 324 ASN ASN A . n 
A 1 344 TYR 344 325 325 TYR TYR A . n 
A 1 345 VAL 345 326 326 VAL VAL A . n 
A 1 346 ALA 346 327 327 ALA ALA A . n 
A 1 347 ASP 347 328 328 ASP ASP A . n 
A 1 348 LEU 348 329 329 LEU LEU A . n 
A 1 349 GLY 349 330 330 GLY GLY A . n 
A 1 350 ALA 350 331 331 ALA ALA A . n 
A 1 351 MET 351 332 332 MET MET A . n 
A 1 352 VAL 352 333 333 VAL VAL A . n 
A 1 353 VAL 353 334 334 VAL VAL A . n 
A 1 354 THR 354 335 335 THR THR A . n 
A 1 355 GLY 355 336 336 GLY GLY A . n 
A 1 356 LEU 356 337 337 LEU LEU A . n 
A 1 357 GLY 357 338 338 GLY GLY A . n 
A 1 358 GLY 358 339 339 GLY GLY A . n 
A 1 359 ASN 359 340 340 ASN ASN A . n 
A 1 360 PRO 360 341 341 PRO PRO A . n 
A 1 361 MET 361 342 342 MET MET A . n 
A 1 362 ALA 362 343 343 ALA ALA A . n 
A 1 363 VAL 363 344 344 VAL VAL A . n 
A 1 364 VAL 364 345 345 VAL VAL A . n 
A 1 365 SER 365 346 346 SER SER A . n 
A 1 366 LYS 366 347 347 LYS LYS A . n 
A 1 367 GLN 367 348 348 GLN GLN A . n 
A 1 368 VAL 368 349 349 VAL VAL A . n 
A 1 369 ASN 369 350 350 ASN ASN A . n 
A 1 370 MET 370 351 351 MET MET A . n 
A 1 371 GLU 371 352 352 GLU GLU A . n 
A 1 372 LEU 372 353 353 LEU LEU A . n 
A 1 373 ALA 373 354 354 ALA ALA A . n 
A 1 374 LYS 374 355 355 LYS LYS A . n 
A 1 375 ILE 375 356 356 ILE ILE A . n 
A 1 376 LYS 376 357 357 LYS LYS A . n 
A 1 377 GLN 377 358 358 GLN GLN A . n 
A 1 378 LYS 378 359 359 LYS LYS A . n 
A 1 379 CYS 379 360 360 CYS CYS A . n 
A 1 380 PRO 380 361 361 PRO PRO A . n 
A 1 381 LEU 381 362 362 LEU LEU A . n 
A 1 382 TYR 382 363 363 TYR TYR A . n 
A 1 383 GLU 383 364 364 GLU GLU A . n 
A 1 384 ALA 384 365 365 ALA ALA A . n 
A 1 385 ASN 385 366 366 ASN ASN A . n 
A 1 386 GLY 386 367 367 GLY GLY A . n 
A 1 387 GLN 387 368 368 GLN GLN A . n 
A 1 388 ALA 388 369 369 ALA ALA A . n 
A 1 389 VAL 389 370 370 VAL VAL A . n 
A 1 390 PRO 390 371 371 PRO PRO A . n 
A 1 391 LYS 391 372 372 LYS LYS A . n 
A 1 392 GLU 392 373 373 GLU GLU A . n 
A 1 393 LYS 393 374 374 LYS LYS A . n 
A 1 394 ASP 394 375 375 ASP ASP A . n 
A 1 395 GLU 395 376 376 GLU GLU A . n 
A 1 396 MET 396 377 377 MET MET A . n 
A 1 397 VAL 397 378 378 VAL VAL A . n 
A 1 398 GLU 398 379 379 GLU GLU A . n 
A 1 399 GLN 399 380 380 GLN GLN A . n 
A 1 400 GLU 400 381 381 GLU GLU A . n 
A 1 401 PHE 401 382 382 PHE PHE A . n 
A 1 402 ASN 402 383 383 ASN ASN A . n 
A 1 403 ARG 403 384 384 ARG ARG A . n 
A 1 404 LEU 404 385 385 LEU LEU A . n 
A 1 405 LEU 405 386 386 LEU LEU A . n 
A 1 406 GLU 406 387 387 GLU GLU A . n 
A 1 407 ALA 407 388 388 ALA ALA A . n 
A 1 408 THR 408 389 389 THR THR A . n 
A 1 409 SER 409 390 390 SER SER A . n 
A 1 410 TYR 410 391 391 TYR TYR A . n 
A 1 411 LEU 411 392 392 LEU LEU A . n 
A 1 412 SER 412 393 393 SER SER A . n 
A 1 413 HIS 413 394 394 HIS HIS A . n 
A 1 414 GLN 414 395 395 GLN GLN A . n 
A 1 415 LEU 415 396 396 LEU LEU A . n 
A 1 416 ASP 416 397 397 ASP ASP A . n 
A 1 417 PHE 417 398 398 PHE PHE A . n 
A 1 418 ASN 418 399 399 ASN ASN A . n 
A 1 419 VAL 419 400 400 VAL VAL A . n 
A 1 420 LEU 420 401 401 LEU LEU A . n 
A 1 421 ASN 421 402 402 ASN ASN A . n 
A 1 422 ASN 422 403 403 ASN ASN A . n 
A 1 423 LYS 423 404 404 LYS LYS A . n 
A 1 424 PRO 424 405 405 PRO PRO A . n 
A 1 425 VAL 425 406 406 VAL VAL A . n 
A 1 426 SER 426 407 407 SER SER A . n 
A 1 427 LEU 427 408 408 LEU LEU A . n 
A 1 428 GLY 428 409 409 GLY GLY A . n 
A 1 429 GLN 429 410 410 GLN GLN A . n 
A 1 430 ALA 430 411 411 ALA ALA A . n 
A 1 431 LEU 431 412 412 LEU LEU A . n 
A 1 432 GLU 432 413 413 GLU GLU A . n 
A 1 433 VAL 433 414 414 VAL VAL A . n 
A 1 434 VAL 434 415 415 VAL VAL A . n 
A 1 435 ILE 435 416 416 ILE ILE A . n 
A 1 436 GLN 436 417 417 GLN GLN A . n 
A 1 437 LEU 437 418 418 LEU LEU A . n 
A 1 438 GLN 438 419 419 GLN GLN A . n 
A 1 439 GLU 439 420 420 GLU GLU A . n 
A 1 440 LYS 440 421 421 LYS LYS A . n 
A 1 441 HIS 441 422 422 HIS HIS A . n 
A 1 442 VAL 442 423 423 VAL VAL A . n 
A 1 443 LYS 443 424 424 LYS LYS A . n 
A 1 444 ASP 444 425 425 ASP ASP A . n 
A 1 445 GLU 445 426 426 GLU GLU A . n 
A 1 446 GLN 446 427 427 GLN GLN A . n 
A 1 447 ILE 447 428 428 ILE ILE A . n 
A 1 448 GLU 448 429 429 GLU GLU A . n 
A 1 449 HIS 449 430 430 HIS HIS A . n 
A 1 450 TRP 450 431 431 TRP TRP A . n 
A 1 451 LYS 451 432 432 LYS LYS A . n 
A 1 452 LYS 452 433 433 LYS LYS A . n 
A 1 453 ILE 453 434 434 ILE ILE A . n 
A 1 454 VAL 454 435 435 VAL VAL A . n 
A 1 455 LYS 455 436 436 LYS LYS A . n 
A 1 456 THR 456 437 437 THR THR A . n 
A 1 457 GLN 457 438 438 GLN GLN A . n 
A 1 458 GLU 458 439 439 GLU GLU A . n 
A 1 459 GLU 459 440 440 GLU GLU A . n 
A 1 460 LEU 460 441 441 LEU LEU A . n 
A 1 461 LYS 461 442 442 LYS LYS A . n 
A 1 462 GLU 462 443 443 GLU GLU A . n 
A 1 463 LEU 463 444 444 LEU LEU A . n 
A 1 464 LEU 464 445 445 LEU LEU A . n 
A 1 465 ASN 465 446 446 ASN ASN A . n 
A 1 466 LYS 466 447 447 LYS LYS A . n 
A 1 467 MET 467 448 448 MET MET A . n 
A 1 468 VAL 468 449 449 VAL VAL A . n 
A 1 469 ASN 469 450 450 ASN ASN A . n 
A 1 470 LEU 470 451 451 LEU LEU A . n 
A 1 471 LYS 471 452 452 LYS LYS A . n 
A 1 472 GLU 472 453 453 GLU GLU A . n 
A 1 473 LYS 473 454 454 LYS LYS A . n 
A 1 474 ILE 474 455 455 ILE ILE A . n 
A 1 475 LYS 475 456 456 LYS LYS A . n 
A 1 476 GLU 476 457 457 GLU GLU A . n 
A 1 477 LEU 477 458 458 LEU LEU A . n 
A 1 478 HIS 478 459 459 HIS HIS A . n 
A 1 479 GLN 479 460 460 GLN GLN A . n 
A 1 480 GLN 480 461 461 GLN GLN A . n 
A 1 481 TYR 481 462 462 TYR TYR A . n 
A 1 482 LYS 482 463 463 LYS LYS A . n 
A 1 483 GLU 483 464 464 GLU GLU A . n 
A 1 484 ALA 484 465 465 ALA ALA A . n 
A 1 485 SER 485 466 466 SER SER A . n 
A 1 486 GLU 486 467 467 GLU GLU A . n 
A 1 487 VAL 487 468 468 VAL VAL A . n 
A 1 488 LYS 488 469 469 LYS LYS A . n 
A 1 489 PRO 489 470 470 PRO PRO A . n 
A 1 490 PRO 490 471 471 PRO PRO A . n 
A 1 491 ARG 491 472 472 ARG ARG A . n 
A 1 492 ASP 492 473 473 ASP ASP A . n 
A 1 493 ILE 493 474 474 ILE ILE A . n 
A 1 494 THR 494 475 475 THR THR A . n 
A 1 495 ALA 495 476 476 ALA ALA A . n 
A 1 496 GLU 496 477 477 GLU GLU A . n 
A 1 497 PHE 497 478 478 PHE PHE A . n 
A 1 498 LEU 498 479 479 LEU LEU A . n 
A 1 499 VAL 499 480 480 VAL VAL A . n 
A 1 500 LYS 500 481 481 LYS LYS A . n 
A 1 501 SER 501 482 482 SER SER A . n 
A 1 502 LYS 502 483 483 LYS LYS A . n 
A 1 503 HIS 503 484 484 HIS HIS A . n 
A 1 504 ARG 504 485 485 ARG ARG A . n 
A 1 505 ASP 505 486 486 ASP ASP A . n 
A 1 506 LEU 506 487 487 LEU LEU A . n 
A 1 507 THR 507 488 488 THR THR A . n 
A 1 508 ALA 508 489 489 ALA ALA A . n 
A 1 509 LEU 509 490 490 LEU LEU A . n 
A 1 510 CYS 510 491 491 CYS CYS A . n 
A 1 511 LYS 511 492 492 LYS LYS A . n 
A 1 512 GLU 512 493 493 GLU GLU A . n 
A 1 513 TYR 513 494 494 TYR TYR A . n 
A 1 514 ASP 514 495 495 ASP ASP A . n 
A 1 515 GLU 515 496 496 GLU GLU A . n 
A 1 516 LEU 516 497 497 LEU LEU A . n 
A 1 517 ALA 517 498 498 ALA ALA A . n 
A 1 518 GLU 518 499 499 GLU GLU A . n 
A 1 519 THR 519 500 500 THR THR A . n 
A 1 520 GLN 520 501 501 GLN GLN A . n 
A 1 521 GLY 521 502 502 GLY GLY A . n 
A 1 522 LYS 522 503 503 LYS LYS A . n 
A 1 523 LEU 523 504 504 LEU LEU A . n 
A 1 524 GLU 524 505 505 GLU GLU A . n 
A 1 525 GLU 525 506 506 GLU GLU A . n 
A 1 526 LYS 526 507 507 LYS LYS A . n 
A 1 527 LEU 527 508 508 LEU LEU A . n 
A 1 528 GLN 528 509 509 GLN GLN A . n 
A 1 529 GLU 529 510 510 GLU GLU A . n 
A 1 530 LEU 530 511 511 LEU LEU A . n 
A 1 531 GLU 531 512 512 GLU GLU A . n 
A 1 532 ALA 532 513 513 ALA ALA A . n 
A 1 533 ASN 533 514 514 ASN ASN A . n 
A 1 534 PRO 534 515 515 PRO PRO A . n 
A 1 535 PRO 535 516 516 PRO PRO A . n 
A 1 536 SER 536 517 517 SER SER A . n 
A 1 537 ASP 537 518 518 ASP ASP A . n 
A 1 538 VAL 538 519 519 VAL VAL A . n 
A 1 539 TYR 539 520 520 TYR TYR A . n 
A 1 540 LEU 540 521 521 LEU LEU A . n 
A 1 541 SER 541 522 522 SER SER A . n 
A 1 542 SER 542 523 523 SER SER A . n 
A 1 543 ARG 543 524 524 ARG ARG A . n 
A 1 544 ASP 544 525 525 ASP ASP A . n 
A 1 545 ARG 545 526 526 ARG ARG A . n 
A 1 546 GLN 546 527 527 GLN GLN A . n 
A 1 547 ILE 547 528 528 ILE ILE A . n 
A 1 548 LEU 548 529 529 LEU LEU A . n 
A 1 549 ASP 549 530 530 ASP ASP A . n 
A 1 550 TRP 550 531 531 TRP TRP A . n 
A 1 551 HIS 551 532 532 HIS HIS A . n 
A 1 552 PHE 552 533 533 PHE PHE A . n 
A 1 553 ALA 553 534 534 ALA ALA A . n 
A 1 554 ASN 554 535 535 ASN ASN A . n 
A 1 555 LEU 555 536 536 LEU LEU A . n 
A 1 556 GLU 556 537 537 GLU GLU A . n 
A 1 557 PHE 557 538 538 PHE PHE A . n 
A 1 558 ALA 558 539 539 ALA ALA A . n 
A 1 559 ASN 559 540 540 ASN ASN A . n 
A 1 560 ALA 560 541 541 ALA ALA A . n 
A 1 561 THR 561 542 542 THR THR A . n 
A 1 562 PRO 562 543 543 PRO PRO A . n 
A 1 563 LEU 563 544 544 LEU LEU A . n 
A 1 564 SER 564 545 545 SER SER A . n 
A 1 565 THR 565 546 546 THR THR A . n 
A 1 566 LEU 566 547 547 LEU LEU A . n 
A 1 567 SER 567 548 548 SER SER A . n 
A 1 568 LEU 568 549 549 LEU LEU A . n 
A 1 569 LYS 569 550 550 LYS LYS A . n 
A 1 570 HIS 570 551 551 HIS HIS A . n 
A 1 571 TRP 571 552 552 TRP TRP A . n 
A 1 572 ASP 572 553 553 ASP ASP A . n 
A 1 573 GLN 573 554 554 GLN GLN A . n 
A 1 574 ASP 574 555 555 ASP ASP A . n 
A 1 575 ASP 575 556 556 ASP ASP A . n 
A 1 576 ASP 576 557 557 ASP ASP A . n 
A 1 577 PHE 577 558 558 PHE PHE A . n 
A 1 578 GLU 578 559 559 GLU GLU A . n 
A 1 579 PHE 579 560 560 PHE PHE A . n 
A 1 580 THR 580 561 561 THR THR A . n 
A 1 581 GLY 581 562 562 GLY GLY A . n 
A 1 582 SER 582 563 563 SER SER A . n 
A 1 583 HIS 583 564 564 HIS HIS A . n 
A 1 584 LEU 584 565 565 LEU LEU A . n 
A 1 585 THR 585 566 566 THR THR A . n 
A 1 586 VAL 586 567 567 VAL VAL A . n 
A 1 587 ARG 587 568 568 ARG ARG A . n 
A 1 588 ASN 588 569 569 ASN ASN A . n 
A 1 589 GLY 589 570 570 GLY GLY A . n 
A 1 590 TYR 590 571 571 TYR TYR A . n 
A 1 591 SER 591 572 572 SER SER A . n 
A 1 592 CYS 592 573 573 CYS CYS A . n 
A 1 593 VAL 593 574 574 VAL VAL A . n 
A 1 594 PRO 594 575 575 PRO PRO A . n 
A 1 595 VAL 595 576 576 VAL VAL A . n 
A 1 596 ALA 596 577 577 ALA ALA A . n 
A 1 597 LEU 597 578 578 LEU LEU A . n 
A 1 598 ALA 598 579 579 ALA ALA A . n 
A 1 599 GLU 599 580 580 GLU GLU A . n 
A 1 600 GLY 600 581 581 GLY GLY A . n 
A 1 601 LEU 601 582 582 LEU LEU A . n 
A 1 602 ASP 602 583 583 ASP ASP A . n 
A 1 603 ILE 603 584 584 ILE ILE A . n 
A 1 604 LYS 604 585 585 LYS LYS A . n 
A 1 605 LEU 605 586 586 LEU LEU A . n 
A 1 606 ASN 606 587 587 ASN ASN A . n 
A 1 607 THR 607 588 588 THR THR A . n 
A 1 608 ALA 608 589 589 ALA ALA A . n 
A 1 609 VAL 609 590 590 VAL VAL A . n 
A 1 610 ARG 610 591 591 ARG ARG A . n 
A 1 611 GLN 611 592 592 GLN GLN A . n 
A 1 612 VAL 612 593 593 VAL VAL A . n 
A 1 613 ARG 613 594 594 ARG ARG A . n 
A 1 614 TYR 614 595 595 TYR TYR A . n 
A 1 615 THR 615 596 596 THR THR A . n 
A 1 616 ALA 616 597 597 ALA ALA A . n 
A 1 617 SER 617 598 598 SER SER A . n 
A 1 618 GLY 618 599 599 GLY GLY A . n 
A 1 619 CYS 619 600 600 CYS CYS A . n 
A 1 620 GLU 620 601 601 GLU GLU A . n 
A 1 621 VAL 621 602 602 VAL VAL A . n 
A 1 622 ILE 622 603 603 ILE ILE A . n 
A 1 623 ALA 623 604 604 ALA ALA A . n 
A 1 624 VAL 624 605 605 VAL VAL A . n 
A 1 625 ASN 625 606 606 ASN ASN A . n 
A 1 626 THR 626 607 607 THR THR A . n 
A 1 627 ARG 627 608 608 ARG ARG A . n 
A 1 628 SER 628 609 609 SER SER A . n 
A 1 629 THR 629 610 610 THR THR A . n 
A 1 630 SER 630 611 611 SER SER A . n 
A 1 631 GLN 631 612 612 GLN GLN A . n 
A 1 632 THR 632 613 613 THR THR A . n 
A 1 633 PHE 633 614 614 PHE PHE A . n 
A 1 634 ILE 634 615 615 ILE ILE A . n 
A 1 635 TYR 635 616 616 TYR TYR A . n 
A 1 636 LYS 636 617 617 LYS LYS A . n 
A 1 637 CYS 637 618 618 CYS CYS A . n 
A 1 638 ASP 638 619 619 ASP ASP A . n 
A 1 639 ALA 639 620 620 ALA ALA A . n 
A 1 640 VAL 640 621 621 VAL VAL A . n 
A 1 641 LEU 641 622 622 LEU LEU A . n 
A 1 642 CYS 642 623 623 CYS CYS A . n 
A 1 643 THR 643 624 624 THR THR A . n 
A 1 644 LEU 644 625 625 LEU LEU A . n 
A 1 645 PRO 645 626 626 PRO PRO A . n 
A 1 646 LEU 646 627 627 LEU LEU A . n 
A 1 647 GLY 647 628 628 GLY GLY A . n 
A 1 648 VAL 648 629 629 VAL VAL A . n 
A 1 649 LEU 649 630 630 LEU LEU A . n 
A 1 650 LYS 650 631 631 LYS LYS A . n 
A 1 651 GLN 651 632 632 GLN GLN A . n 
A 1 652 GLN 652 633 633 GLN GLN A . n 
A 1 653 PRO 653 634 634 PRO PRO A . n 
A 1 654 PRO 654 635 635 PRO PRO A . n 
A 1 655 ALA 655 636 636 ALA ALA A . n 
A 1 656 VAL 656 637 637 VAL VAL A . n 
A 1 657 GLN 657 638 638 GLN GLN A . n 
A 1 658 PHE 658 639 639 PHE PHE A . n 
A 1 659 VAL 659 640 640 VAL VAL A . n 
A 1 660 PRO 660 641 641 PRO PRO A . n 
A 1 661 PRO 661 642 642 PRO PRO A . n 
A 1 662 LEU 662 643 643 LEU LEU A . n 
A 1 663 PRO 663 644 644 PRO PRO A . n 
A 1 664 GLU 664 645 645 GLU GLU A . n 
A 1 665 TRP 665 646 646 TRP TRP A . n 
A 1 666 LYS 666 647 647 LYS LYS A . n 
A 1 667 THR 667 648 648 THR THR A . n 
A 1 668 SER 668 649 649 SER SER A . n 
A 1 669 ALA 669 650 650 ALA ALA A . n 
A 1 670 VAL 670 651 651 VAL VAL A . n 
A 1 671 GLN 671 652 652 GLN GLN A . n 
A 1 672 ARG 672 653 653 ARG ARG A . n 
A 1 673 MET 673 654 654 MET MET A . n 
A 1 674 GLY 674 655 655 GLY GLY A . n 
A 1 675 PHE 675 656 656 PHE PHE A . n 
A 1 676 GLY 676 657 657 GLY GLY A . n 
A 1 677 ASN 677 658 658 ASN ASN A . n 
A 1 678 LEU 678 659 659 LEU LEU A . n 
A 1 679 ASN 679 660 660 ASN ASN A . n 
A 1 680 LYS 680 661 661 LYS LYS A . n 
A 1 681 VAL 681 662 662 VAL VAL A . n 
A 1 682 VAL 682 663 663 VAL VAL A . n 
A 1 683 LEU 683 664 664 LEU LEU A . n 
A 1 684 CYS 684 665 665 CYS CYS A . n 
A 1 685 PHE 685 666 666 PHE PHE A . n 
A 1 686 ASP 686 667 667 ASP ASP A . n 
A 1 687 ARG 687 668 668 ARG ARG A . n 
A 1 688 VAL 688 669 669 VAL VAL A . n 
A 1 689 PHE 689 670 670 PHE PHE A . n 
A 1 690 TRP 690 671 671 TRP TRP A . n 
A 1 691 ASP 691 672 672 ASP ASP A . n 
A 1 692 PRO 692 673 673 PRO PRO A . n 
A 1 693 SER 693 674 674 SER SER A . n 
A 1 694 VAL 694 675 675 VAL VAL A . n 
A 1 695 ASN 695 676 676 ASN ASN A . n 
A 1 696 LEU 696 677 677 LEU LEU A . n 
A 1 697 PHE 697 678 678 PHE PHE A . n 
A 1 698 GLY 698 679 679 GLY GLY A . n 
A 1 699 HIS 699 680 680 HIS HIS A . n 
A 1 700 VAL 700 681 681 VAL VAL A . n 
A 1 701 GLY 701 682 682 GLY GLY A . n 
A 1 702 SER 702 683 683 SER SER A . n 
A 1 703 THR 703 684 684 THR THR A . n 
A 1 704 THR 704 685 685 THR THR A . n 
A 1 705 ALA 705 686 686 ALA ALA A . n 
A 1 706 SER 706 687 687 SER SER A . n 
A 1 707 ARG 707 688 688 ARG ARG A . n 
A 1 708 GLY 708 689 689 GLY GLY A . n 
A 1 709 GLU 709 690 690 GLU GLU A . n 
A 1 710 LEU 710 691 691 LEU LEU A . n 
A 1 711 PHE 711 692 692 PHE PHE A . n 
A 1 712 LEU 712 693 693 LEU LEU A . n 
A 1 713 PHE 713 694 694 PHE PHE A . n 
A 1 714 TRP 714 695 695 TRP TRP A . n 
A 1 715 ASN 715 696 696 ASN ASN A . n 
A 1 716 LEU 716 697 697 LEU LEU A . n 
A 1 717 TYR 717 698 698 TYR TYR A . n 
A 1 718 LYS 718 699 699 LYS LYS A . n 
A 1 719 ALA 719 700 700 ALA ALA A . n 
A 1 720 PRO 720 701 701 PRO PRO A . n 
A 1 721 ILE 721 702 702 ILE ILE A . n 
A 1 722 LEU 722 703 703 LEU LEU A . n 
A 1 723 LEU 723 704 704 LEU LEU A . n 
A 1 724 ALA 724 705 705 ALA ALA A . n 
A 1 725 LEU 725 706 706 LEU LEU A . n 
A 1 726 VAL 726 707 707 VAL VAL A . n 
A 1 727 ALA 727 708 708 ALA ALA A . n 
A 1 728 GLY 728 709 709 GLY GLY A . n 
A 1 729 GLU 729 710 710 GLU GLU A . n 
A 1 730 ALA 730 711 711 ALA ALA A . n 
A 1 731 ALA 731 712 712 ALA ALA A . n 
A 1 732 GLY 732 713 713 GLY GLY A . n 
A 1 733 ILE 733 714 714 ILE ILE A . n 
A 1 734 MET 734 715 715 MET MET A . n 
A 1 735 GLU 735 716 716 GLU GLU A . n 
A 1 736 ASN 736 717 717 ASN ASN A . n 
A 1 737 ILE 737 718 718 ILE ILE A . n 
A 1 738 SER 738 719 719 SER SER A . n 
A 1 739 ASP 739 720 720 ASP ASP A . n 
A 1 740 ASP 740 721 721 ASP ASP A . n 
A 1 741 VAL 741 722 722 VAL VAL A . n 
A 1 742 ILE 742 723 723 ILE ILE A . n 
A 1 743 VAL 743 724 724 VAL VAL A . n 
A 1 744 GLY 744 725 725 GLY GLY A . n 
A 1 745 ARG 745 726 726 ARG ARG A . n 
A 1 746 CYS 746 727 727 CYS CYS A . n 
A 1 747 LEU 747 728 728 LEU LEU A . n 
A 1 748 ALA 748 729 729 ALA ALA A . n 
A 1 749 ILE 749 730 730 ILE ILE A . n 
A 1 750 LEU 750 731 731 LEU LEU A . n 
A 1 751 LYS 751 732 732 LYS LYS A . n 
A 1 752 GLY 752 733 733 GLY GLY A . n 
A 1 753 ILE 753 734 734 ILE ILE A . n 
A 1 754 PHE 754 735 735 PHE PHE A . n 
A 1 755 GLY 755 736 736 GLY GLY A . n 
A 1 756 SER 756 737 737 SER SER A . n 
A 1 757 SER 757 738 738 SER SER A . n 
A 1 758 ALA 758 739 739 ALA ALA A . n 
A 1 759 VAL 759 740 740 VAL VAL A . n 
A 1 760 PRO 760 741 741 PRO PRO A . n 
A 1 761 GLN 761 742 742 GLN GLN A . n 
A 1 762 PRO 762 743 743 PRO PRO A . n 
A 1 763 LYS 763 744 744 LYS LYS A . n 
A 1 764 GLU 764 745 745 GLU GLU A . n 
A 1 765 THR 765 746 746 THR THR A . n 
A 1 766 VAL 766 747 747 VAL VAL A . n 
A 1 767 VAL 767 748 748 VAL VAL A . n 
A 1 768 SER 768 749 749 SER SER A . n 
A 1 769 ARG 769 750 750 ARG ARG A . n 
A 1 770 TRP 770 751 751 TRP TRP A . n 
A 1 771 ARG 771 752 752 ARG ARG A . n 
A 1 772 ALA 772 753 753 ALA ALA A . n 
A 1 773 ASP 773 754 754 ASP ASP A . n 
A 1 774 PRO 774 755 755 PRO PRO A . n 
A 1 775 TRP 775 756 756 TRP TRP A . n 
A 1 776 ALA 776 757 757 ALA ALA A . n 
A 1 777 ARG 777 758 758 ARG ARG A . n 
A 1 778 GLY 778 759 759 GLY GLY A . n 
A 1 779 SER 779 760 760 SER SER A . n 
A 1 780 TYR 780 761 761 TYR TYR A . n 
A 1 781 SER 781 762 762 SER SER A . n 
A 1 782 TYR 782 763 763 TYR TYR A . n 
A 1 783 VAL 783 764 764 VAL VAL A . n 
A 1 784 ALA 784 765 765 ALA ALA A . n 
A 1 785 ALA 785 766 766 ALA ALA A . n 
A 1 786 GLY 786 767 767 GLY GLY A . n 
A 1 787 SER 787 768 768 SER SER A . n 
A 1 788 SER 788 769 769 SER SER A . n 
A 1 789 GLY 789 770 770 GLY GLY A . n 
A 1 790 ASN 790 771 771 ASN ASN A . n 
A 1 791 ASP 791 772 772 ASP ASP A . n 
A 1 792 TYR 792 773 773 TYR TYR A . n 
A 1 793 ASP 793 774 774 ASP ASP A . n 
A 1 794 LEU 794 775 775 LEU LEU A . n 
A 1 795 MET 795 776 776 MET MET A . n 
A 1 796 ALA 796 777 777 ALA ALA A . n 
A 1 797 GLN 797 778 778 GLN GLN A . n 
A 1 798 PRO 798 779 779 PRO PRO A . n 
A 1 799 ILE 799 780 780 ILE ILE A . n 
A 1 800 THR 800 781 781 THR THR A . n 
A 1 801 PRO 801 782 782 PRO PRO A . n 
A 1 802 GLY 802 783 783 GLY GLY A . n 
A 1 803 PRO 803 784 784 PRO PRO A . n 
A 1 804 SER 804 785 785 SER SER A . n 
A 1 805 ILE 805 786 786 ILE ILE A . n 
A 1 806 PRO 806 787 787 PRO PRO A . n 
A 1 807 GLY 807 788 788 GLY GLY A . n 
A 1 808 ALA 808 789 789 ALA ALA A . n 
A 1 809 PRO 809 790 790 PRO PRO A . n 
A 1 810 GLN 810 791 791 GLN GLN A . n 
A 1 811 PRO 811 792 792 PRO PRO A . n 
A 1 812 ILE 812 793 793 ILE ILE A . n 
A 1 813 PRO 813 794 794 PRO PRO A . n 
A 1 814 ARG 814 795 795 ARG ARG A . n 
A 1 815 LEU 815 796 796 LEU LEU A . n 
A 1 816 PHE 816 797 797 PHE PHE A . n 
A 1 817 PHE 817 798 798 PHE PHE A . n 
A 1 818 ALA 818 799 799 ALA ALA A . n 
A 1 819 GLY 819 800 800 GLY GLY A . n 
A 1 820 GLU 820 801 801 GLU GLU A . n 
A 1 821 HIS 821 802 802 HIS HIS A . n 
A 1 822 THR 822 803 803 THR THR A . n 
A 1 823 ILE 823 804 804 ILE ILE A . n 
A 1 824 ARG 824 805 805 ARG ARG A . n 
A 1 825 ASN 825 806 806 ASN ASN A . n 
A 1 826 TYR 826 807 807 TYR TYR A . n 
A 1 827 PRO 827 808 808 PRO PRO A . n 
A 1 828 ALA 828 809 809 ALA ALA A . n 
A 1 829 THR 829 810 810 THR THR A . n 
A 1 830 VAL 830 811 811 VAL VAL A . n 
A 1 831 HIS 831 812 812 HIS HIS A . n 
A 1 832 GLY 832 813 813 GLY GLY A . n 
A 1 833 ALA 833 814 814 ALA ALA A . n 
A 1 834 LEU 834 815 815 LEU LEU A . n 
A 1 835 LEU 835 816 816 LEU LEU A . n 
A 1 836 SER 836 817 817 SER SER A . n 
A 1 837 GLY 837 818 818 GLY GLY A . n 
A 1 838 LEU 838 819 819 LEU LEU A . n 
A 1 839 ARG 839 820 820 ARG ARG A . n 
A 1 840 GLU 840 821 821 GLU GLU A . n 
A 1 841 ALA 841 822 822 ALA ALA A . n 
A 1 842 GLY 842 823 823 GLY GLY A . n 
A 1 843 ARG 843 824 824 ARG ARG A . n 
A 1 844 ILE 844 825 825 ILE ILE A . n 
A 1 845 ALA 845 826 826 ALA ALA A . n 
A 1 846 ASP 846 827 827 ASP ASP A . n 
A 1 847 GLN 847 828 828 GLN GLN A . n 
A 1 848 PHE 848 829 829 PHE PHE A . n 
A 1 849 LEU 849 830 830 LEU LEU A . n 
A 1 850 GLY 850 831 831 GLY GLY A . n 
A 1 851 ALA 851 832 832 ALA ALA A . n 
A 1 852 MET 852 833 833 MET MET A . n 
A 1 853 TYR 853 834 834 TYR TYR A . n 
A 1 854 THR 854 835 835 THR THR A . n 
A 1 855 LEU 855 836 836 LEU LEU A . n 
A 1 856 PRO 856 837 ?   ?   ?   A . n 
A 1 857 ARG 857 838 ?   ?   ?   A . n 
A 1 858 GLN 858 839 ?   ?   ?   A . n 
A 1 859 ALA 859 840 ?   ?   ?   A . n 
A 1 860 THR 860 841 ?   ?   ?   A . n 
A 1 861 PRO 861 842 ?   ?   ?   A . n 
A 1 862 GLY 862 843 ?   ?   ?   A . n 
A 1 863 VAL 863 844 ?   ?   ?   A . n 
A 1 864 PRO 864 845 ?   ?   ?   A . n 
A 1 865 ALA 865 846 ?   ?   ?   A . n 
A 1 866 GLN 866 847 ?   ?   ?   A . n 
A 1 867 GLN 867 848 ?   ?   ?   A . n 
A 1 868 SER 868 849 ?   ?   ?   A . n 
A 1 869 PRO 869 850 ?   ?   ?   A . n 
A 1 870 SER 870 851 ?   ?   ?   A . n 
A 1 871 MET 871 852 ?   ?   ?   A . n 
B 2 1   GLY 1   297 ?   ?   ?   B . n 
B 2 2   PRO 2   298 ?   ?   ?   B . n 
B 2 3   LEU 3   299 ?   ?   ?   B . n 
B 2 4   GLY 4   300 ?   ?   ?   B . n 
B 2 5   SER 5   301 ?   ?   ?   B . n 
B 2 6   PRO 6   302 ?   ?   ?   B . n 
B 2 7   GLU 7   303 ?   ?   ?   B . n 
B 2 8   PHE 8   304 ?   ?   ?   B . n 
B 2 9   ARG 9   305 ?   ?   ?   B . n 
B 2 10  ALA 10  306 ?   ?   ?   B . n 
B 2 11  LYS 11  307 ?   ?   ?   B . n 
B 2 12  ARG 12  308 308 ARG ARG B . n 
B 2 13  LYS 13  309 309 LYS LYS B . n 
B 2 14  PRO 14  310 310 PRO PRO B . n 
B 2 15  PRO 15  311 311 PRO PRO B . n 
B 2 16  LYS 16  312 312 LYS LYS B . n 
B 2 17  GLY 17  313 313 GLY GLY B . n 
B 2 18  MET 18  314 314 MET MET B . n 
B 2 19  PHE 19  315 315 PHE PHE B . n 
B 2 20  LEU 20  316 316 LEU LEU B . n 
B 2 21  SER 21  317 317 SER SER B . n 
B 2 22  GLN 22  318 318 GLN GLN B . n 
B 2 23  GLU 23  319 319 GLU GLU B . n 
B 2 24  ASP 24  320 320 ASP ASP B . n 
B 2 25  VAL 25  321 321 VAL VAL B . n 
B 2 26  GLU 26  322 322 GLU GLU B . n 
B 2 27  ALA 27  323 323 ALA ALA B . n 
B 2 28  VAL 28  324 324 VAL VAL B . n 
B 2 29  SER 29  325 325 SER SER B . n 
B 2 30  ALA 30  326 326 ALA ALA B . n 
B 2 31  ASN 31  327 327 ASN ASN B . n 
B 2 32  ALA 32  328 328 ALA ALA B . n 
B 2 33  THR 33  329 329 THR THR B . n 
B 2 34  ALA 34  330 330 ALA ALA B . n 
B 2 35  ALA 35  331 331 ALA ALA B . n 
B 2 36  THR 36  332 332 THR THR B . n 
B 2 37  THR 37  333 333 THR THR B . n 
B 2 38  VAL 38  334 334 VAL VAL B . n 
B 2 39  LEU 39  335 335 LEU LEU B . n 
B 2 40  ARG 40  336 336 ARG ARG B . n 
B 2 41  GLN 41  337 337 GLN GLN B . n 
B 2 42  LEU 42  338 338 LEU LEU B . n 
B 2 43  ASP 43  339 339 ASP ASP B . n 
B 2 44  MET 44  340 340 MET MET B . n 
B 2 45  GLU 45  341 341 GLU GLU B . n 
B 2 46  LEU 46  342 342 LEU LEU B . n 
B 2 47  VAL 47  343 343 VAL VAL B . n 
B 2 48  SER 48  344 344 SER SER B . n 
B 2 49  VAL 49  345 345 VAL VAL B . n 
B 2 50  LYS 50  346 346 LYS LYS B . n 
B 2 51  ARG 51  347 347 ARG ARG B . n 
B 2 52  GLN 52  348 348 GLN GLN B . n 
B 2 53  ILE 53  349 349 ILE ILE B . n 
B 2 54  GLN 54  350 350 GLN GLN B . n 
B 2 55  ASN 55  351 351 ASN ASN B . n 
B 2 56  ILE 56  352 352 ILE ILE B . n 
B 2 57  LYS 57  353 353 LYS LYS B . n 
B 2 58  GLN 58  354 354 GLN GLN B . n 
B 2 59  THR 59  355 355 THR THR B . n 
B 2 60  ASN 60  356 356 ASN ASN B . n 
B 2 61  SER 61  357 357 SER SER B . n 
B 2 62  ALA 62  358 358 ALA ALA B . n 
B 2 63  LEU 63  359 359 LEU LEU B . n 
B 2 64  LYS 64  360 360 LYS LYS B . n 
B 2 65  GLU 65  361 361 GLU GLU B . n 
B 2 66  LYS 66  362 362 LYS LYS B . n 
B 2 67  LEU 67  363 363 LEU LEU B . n 
B 2 68  ASP 68  364 364 ASP ASP B . n 
B 2 69  GLY 69  365 365 GLY GLY B . n 
B 2 70  GLY 70  366 366 GLY GLY B . n 
B 2 71  ILE 71  367 367 ILE ILE B . n 
B 2 72  GLU 72  368 368 GLU GLU B . n 
B 2 73  PRO 73  369 369 PRO PRO B . n 
B 2 74  TYR 74  370 370 TYR TYR B . n 
B 2 75  ARG 75  371 371 ARG ARG B . n 
B 2 76  LEU 76  372 372 LEU LEU B . n 
B 2 77  PRO 77  373 373 PRO PRO B . n 
B 2 78  GLU 78  374 374 GLU GLU B . n 
B 2 79  VAL 79  375 375 VAL VAL B . n 
B 2 80  ILE 80  376 376 ILE ILE B . n 
B 2 81  GLN 81  377 377 GLN GLN B . n 
B 2 82  LYS 82  378 378 LYS LYS B . n 
B 2 83  CYS 83  379 379 CYS CYS B . n 
B 2 84  ASN 84  380 380 ASN ASN B . n 
B 2 85  ALA 85  381 381 ALA ALA B . n 
B 2 86  ARG 86  382 382 ARG ARG B . n 
B 2 87  TRP 87  383 383 TRP TRP B . n 
B 2 88  THR 88  384 384 THR THR B . n 
B 2 89  THR 89  385 385 THR THR B . n 
B 2 90  GLU 90  386 386 GLU GLU B . n 
B 2 91  GLU 91  387 387 GLU GLU B . n 
B 2 92  GLN 92  388 388 GLN GLN B . n 
B 2 93  LEU 93  389 389 LEU LEU B . n 
B 2 94  LEU 94  390 390 LEU LEU B . n 
B 2 95  ALA 95  391 391 ALA ALA B . n 
B 2 96  VAL 96  392 392 VAL VAL B . n 
B 2 97  GLN 97  393 393 GLN GLN B . n 
B 2 98  ALA 98  394 394 ALA ALA B . n 
B 2 99  ILE 99  395 395 ILE ILE B . n 
B 2 100 ARG 100 396 396 ARG ARG B . n 
B 2 101 LYS 101 397 397 LYS LYS B . n 
B 2 102 TYR 102 398 398 TYR TYR B . n 
B 2 103 GLY 103 399 399 GLY GLY B . n 
B 2 104 ARG 104 400 400 ARG ARG B . n 
B 2 105 ASP 105 401 401 ASP ASP B . n 
B 2 106 PHE 106 402 402 PHE PHE B . n 
B 2 107 GLN 107 403 403 GLN GLN B . n 
B 2 108 ALA 108 404 404 ALA ALA B . n 
B 2 109 ILE 109 405 405 ILE ILE B . n 
B 2 110 SER 110 406 406 SER SER B . n 
B 2 111 ASP 111 407 407 ASP ASP B . n 
B 2 112 VAL 112 408 408 VAL VAL B . n 
B 2 113 ILE 113 409 409 ILE ILE B . n 
B 2 114 GLY 114 410 410 GLY GLY B . n 
B 2 115 ASN 115 411 411 ASN ASN B . n 
B 2 116 LYS 116 412 412 LYS LYS B . n 
B 2 117 SER 117 413 413 SER SER B . n 
B 2 118 VAL 118 414 414 VAL VAL B . n 
B 2 119 VAL 119 415 415 VAL VAL B . n 
B 2 120 GLN 120 416 416 GLN GLN B . n 
B 2 121 VAL 121 417 417 VAL VAL B . n 
B 2 122 LYS 122 418 418 LYS LYS B . n 
B 2 123 ASN 123 419 419 ASN ASN B . n 
B 2 124 PHE 124 420 420 PHE PHE B . n 
B 2 125 PHE 125 421 421 PHE PHE B . n 
B 2 126 VAL 126 422 422 VAL VAL B . n 
B 2 127 ASN 127 423 423 ASN ASN B . n 
B 2 128 TYR 128 424 424 TYR TYR B . n 
B 2 129 ARG 129 425 425 ARG ARG B . n 
B 2 130 ARG 130 426 426 ARG ARG B . n 
B 2 131 ARG 131 427 427 ARG ARG B . n 
B 2 132 PHE 132 428 428 PHE PHE B . n 
B 2 133 ASN 133 429 429 ASN ASN B . n 
B 2 134 ILE 134 430 430 ILE ILE B . n 
B 2 135 ASP 135 431 431 ASP ASP B . n 
B 2 136 GLU 136 432 432 GLU GLU B . n 
B 2 137 VAL 137 433 433 VAL VAL B . n 
B 2 138 LEU 138 434 434 LEU LEU B . n 
B 2 139 GLN 139 435 435 GLN GLN B . n 
B 2 140 GLU 140 436 436 GLU GLU B . n 
B 2 141 TRP 141 437 437 TRP TRP B . n 
B 2 142 GLU 142 438 438 GLU GLU B . n 
B 2 143 ALA 143 439 439 ALA ALA B . n 
B 2 144 GLU 144 440 440 GLU GLU B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        ZSI 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   ZSI 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 3 ZSI 1 901 901 ZSI DRG A . 
D 4 K   1 902 1   K   K   A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.18.2_3874 1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .           2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER  ? ? ? .           4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8GJ6 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     118.355 
_cell.length_a_esd                 ? 
_cell.length_b                     178.664 
_cell.length_b_esd                 ? 
_cell.length_c                     234.966 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8GJ6 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                23 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'I 2 2 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8GJ6 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             5.57 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          77.92 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              6.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '1.2 Sodium/Potassium Tartrate, 100 mM ADA pH 6.5' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 X 9M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-02-02 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    0.965459 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.965459 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'ESRF BEAMLINE ID30B' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.965459 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ID30B 
_diffrn_source.pdbx_synchrotron_site       ESRF 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       8GJ6 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.77 
_reflns.d_resolution_low                               48.46 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     61770 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           97.5 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                3.4 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          7.2 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               0.95 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.125 
_reflns.pdbx_Rpim_I_all                                0.065 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       208431 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.991 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.106 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.77 
_reflns_shell.d_res_low                                     2.84 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           15792 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             4585 
_reflns_shell.percent_possible_obs                          98.2 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               3.4 
_reflns_shell.pdbx_chi_squared                              0.85 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     0.8 
_reflns_shell.pdbx_Rrim_I_all                               1.967 
_reflns_shell.pdbx_Rpim_I_all                               1.021 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.275 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  1.670 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8GJ6 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.77 
_refine.ls_d_res_low                             48.46 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     61535 
_refine.ls_number_reflns_R_free                  1992 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    96.85 
_refine.ls_percent_reflns_R_free                 3.24 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2240 
_refine.ls_R_factor_R_free                       0.2512 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2231 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.33 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.11 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.90 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.46 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.77 
_refine_hist.d_res_low                        48.46 
_refine_hist.number_atoms_solvent             0 
_refine_hist.number_atoms_total               6361 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        6293 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         68 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.011 ? 6496 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.414 ? 8818 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 9.748 ? 917  ? f_dihedral_angle_d ? ? 
'X-RAY DIFFRACTION' ? 0.077 ? 989  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.008 ? 1140 ? f_plane_restr      ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.77 2.84  . . 143 4226 97.00 . . . . 0.4243 . . . . . . . . . . . 0.4157 
'X-RAY DIFFRACTION' 2.84 2.92  . . 142 4253 99.00 . . . . 0.3955 . . . . . . . . . . . 0.4234 
'X-RAY DIFFRACTION' 2.92 3.00  . . 144 4329 99.00 . . . . 0.3550 . . . . . . . . . . . 0.3774 
'X-RAY DIFFRACTION' 3.00 3.10  . . 143 4250 98.00 . . . . 0.3312 . . . . . . . . . . . 0.3522 
'X-RAY DIFFRACTION' 3.10 3.21  . . 144 4315 98.00 . . . . 0.3115 . . . . . . . . . . . 0.3552 
'X-RAY DIFFRACTION' 3.21 3.34  . . 142 4227 98.00 . . . . 0.2837 . . . . . . . . . . . 0.3633 
'X-RAY DIFFRACTION' 3.34 3.49  . . 143 4246 97.00 . . . . 0.2635 . . . . . . . . . . . 0.3129 
'X-RAY DIFFRACTION' 3.49 3.67  . . 140 4210 96.00 . . . . 0.2516 . . . . . . . . . . . 0.2807 
'X-RAY DIFFRACTION' 3.67 3.90  . . 137 4092 94.00 . . . . 0.2351 . . . . . . . . . . . 0.2389 
'X-RAY DIFFRACTION' 3.90 4.21  . . 143 4272 97.00 . . . . 0.2243 . . . . . . . . . . . 0.2571 
'X-RAY DIFFRACTION' 4.21 4.63  . . 143 4265 97.00 . . . . 0.1914 . . . . . . . . . . . 0.2382 
'X-RAY DIFFRACTION' 4.63 5.30  . . 143 4275 97.00 . . . . 0.1911 . . . . . . . . . . . 0.2490 
'X-RAY DIFFRACTION' 5.30 6.67  . . 143 4292 96.00 . . . . 0.2033 . . . . . . . . . . . 0.2449 
'X-RAY DIFFRACTION' 6.67 48.46 . . 142 4291 93.00 . . . . 0.1574 . . . . . . . . . . . 0.1475 
# 
_struct.entry_id                     8GJ6 
_struct.title                        'LSD1-CoREST in complex with T16' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8GJ6 
_struct_keywords.text            
'Epigenetics, Histone demethylase, Drug resistance, Covalent inhibitor, OXIDOREDUCTASE, OXIDOREDUCTASE-INHIBITOR complex' 
_struct_keywords.pdbx_keywords   OXIDOREDUCTASE/INHIBITOR 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP KDM1A_HUMAN O60341 ? 1 
;MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGS
AGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPP
EEENESEPEEPSGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEA
PYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATF
RKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNV
LNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLV
KSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEF
TGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFV
PPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISD
DVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAG
EHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQATPGVPAQQSPSM
;
1   
2 UNP RCOR1_HUMAN Q9UKL0 ? 2 
;RAKRKPPKGMFLSQEDVEAVSANATAATTVLRQLDMELVSVKRQIQNIKQTNSALKEKLDGGIEPYRLPEVIQKCNARWT
TEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFVNYRRRFNIDEVLQEWEAE
;
308 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8GJ6 A 20 ? 871 ? O60341 1   ? 852 ? 1   852 
2 2 8GJ6 B 9  ? 144 ? Q9UKL0 308 ? 443 ? 305 440 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8GJ6 GLY A 1  ? UNP O60341 ? ? 'expression tag' -18 1  
1 8GJ6 SER A 2  ? UNP O60341 ? ? 'expression tag' -17 2  
1 8GJ6 SER A 3  ? UNP O60341 ? ? 'expression tag' -16 3  
1 8GJ6 HIS A 4  ? UNP O60341 ? ? 'expression tag' -15 4  
1 8GJ6 HIS A 5  ? UNP O60341 ? ? 'expression tag' -14 5  
1 8GJ6 HIS A 6  ? UNP O60341 ? ? 'expression tag' -13 6  
1 8GJ6 HIS A 7  ? UNP O60341 ? ? 'expression tag' -12 7  
1 8GJ6 HIS A 8  ? UNP O60341 ? ? 'expression tag' -11 8  
1 8GJ6 HIS A 9  ? UNP O60341 ? ? 'expression tag' -10 9  
1 8GJ6 SER A 10 ? UNP O60341 ? ? 'expression tag' -9  10 
1 8GJ6 SER A 11 ? UNP O60341 ? ? 'expression tag' -8  11 
1 8GJ6 GLY A 12 ? UNP O60341 ? ? 'expression tag' -7  12 
1 8GJ6 LEU A 13 ? UNP O60341 ? ? 'expression tag' -6  13 
1 8GJ6 VAL A 14 ? UNP O60341 ? ? 'expression tag' -5  14 
1 8GJ6 PRO A 15 ? UNP O60341 ? ? 'expression tag' -4  15 
1 8GJ6 ARG A 16 ? UNP O60341 ? ? 'expression tag' -3  16 
1 8GJ6 GLY A 17 ? UNP O60341 ? ? 'expression tag' -2  17 
1 8GJ6 SER A 18 ? UNP O60341 ? ? 'expression tag' -1  18 
1 8GJ6 HIS A 19 ? UNP O60341 ? ? 'expression tag' 0   19 
2 8GJ6 GLY B 1  ? UNP Q9UKL0 ? ? 'expression tag' 297 20 
2 8GJ6 PRO B 2  ? UNP Q9UKL0 ? ? 'expression tag' 298 21 
2 8GJ6 LEU B 3  ? UNP Q9UKL0 ? ? 'expression tag' 299 22 
2 8GJ6 GLY B 4  ? UNP Q9UKL0 ? ? 'expression tag' 300 23 
2 8GJ6 SER B 5  ? UNP Q9UKL0 ? ? 'expression tag' 301 24 
2 8GJ6 PRO B 6  ? UNP Q9UKL0 ? ? 'expression tag' 302 25 
2 8GJ6 GLU B 7  ? UNP Q9UKL0 ? ? 'expression tag' 303 26 
2 8GJ6 PHE B 8  ? UNP Q9UKL0 ? ? 'expression tag' 304 27 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 5580  ? 
1 MORE         -38   ? 
1 'SSA (A^2)'  37620 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 GLY A 192 ? SER A 200 ? GLY A 173 SER A 181 1 ? 9  
HELX_P HELX_P2  AA2 THR A 208 ? PHE A 215 ? THR A 189 PHE A 196 1 ? 8  
HELX_P HELX_P3  AA3 PHE A 215 ? SER A 220 ? PHE A 196 SER A 201 1 ? 6  
HELX_P HELX_P4  AA4 PRO A 222 ? ASP A 242 ? PRO A 203 ASP A 223 1 ? 21 
HELX_P HELX_P5  AA5 THR A 249 ? LEU A 257 ? THR A 230 LEU A 238 1 ? 9  
HELX_P HELX_P6  AA6 ASP A 264 ? HIS A 278 ? ASP A 245 HIS A 259 1 ? 15 
HELX_P HELX_P7  AA7 GLY A 306 ? PHE A 319 ? GLY A 287 PHE A 300 1 ? 14 
HELX_P HELX_P8  AA8 ASN A 359 ? VAL A 368 ? ASN A 340 VAL A 349 1 ? 10 
HELX_P HELX_P9  AA9 PRO A 390 ? ASP A 416 ? PRO A 371 ASP A 397 1 ? 27 
HELX_P HELX_P10 AB1 SER A 426 ? GLU A 486 ? SER A 407 GLU A 467 1 ? 61 
HELX_P HELX_P11 AB2 ASP A 492 ? LEU A 516 ? ASP A 473 LEU A 497 1 ? 25 
HELX_P HELX_P12 AB3 ALA A 517 ? ASN A 533 ? ALA A 498 ASN A 514 1 ? 17 
HELX_P HELX_P13 AB4 SER A 541 ? ASN A 559 ? SER A 522 ASN A 540 1 ? 19 
HELX_P HELX_P14 AB5 ASP A 574 ? GLU A 578 ? ASP A 555 GLU A 559 5 ? 5  
HELX_P HELX_P15 AB6 SER A 591 ? ALA A 598 ? SER A 572 ALA A 579 1 ? 8  
HELX_P HELX_P16 AB7 PRO A 645 ? GLN A 651 ? PRO A 626 GLN A 632 1 ? 7  
HELX_P HELX_P17 AB8 PRO A 663 ? MET A 673 ? PRO A 644 MET A 654 1 ? 11 
HELX_P HELX_P18 AB9 ALA A 727 ? MET A 734 ? ALA A 708 MET A 715 1 ? 8  
HELX_P HELX_P19 AC1 GLU A 735 ? ILE A 737 ? GLU A 716 ILE A 718 5 ? 3  
HELX_P HELX_P20 AC2 SER A 738 ? GLY A 755 ? SER A 719 GLY A 736 1 ? 18 
HELX_P HELX_P21 AC3 SER A 788 ? MET A 795 ? SER A 769 MET A 776 1 ? 8  
HELX_P HELX_P22 AC4 GLY A 819 ? ILE A 823 ? GLY A 800 ILE A 804 5 ? 5  
HELX_P HELX_P23 AC5 THR A 829 ? LEU A 849 ? THR A 810 LEU A 830 1 ? 21 
HELX_P HELX_P24 AC6 ALA A 851 ? LEU A 855 ? ALA A 832 LEU A 836 5 ? 5  
HELX_P HELX_P25 AC7 SER B 21  ? ALA B 30  ? SER B 317 ALA B 326 1 ? 10 
HELX_P HELX_P26 AC8 THR B 33  ? LEU B 67  ? THR B 329 LEU B 363 1 ? 35 
HELX_P HELX_P27 AC9 ILE B 71  ? ARG B 75  ? ILE B 367 ARG B 371 5 ? 5  
HELX_P HELX_P28 AD1 THR B 88  ? GLY B 103 ? THR B 384 GLY B 399 1 ? 16 
HELX_P HELX_P29 AD2 ASP B 105 ? GLY B 114 ? ASP B 401 GLY B 410 1 ? 10 
HELX_P HELX_P30 AD3 SER B 117 ? TYR B 128 ? SER B 413 TYR B 424 1 ? 12 
HELX_P HELX_P31 AD4 ASN B 133 ? ALA B 143 ? ASN B 429 ALA B 439 1 ? 11 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_conn.id                            metalc1 
_struct_conn.conn_type_id                  metalc 
_struct_conn.pdbx_leaving_atom_flag        ? 
_struct_conn.pdbx_PDB_id                   ? 
_struct_conn.ptnr1_label_asym_id           A 
_struct_conn.ptnr1_label_comp_id           GLU 
_struct_conn.ptnr1_label_seq_id            398 
_struct_conn.ptnr1_label_atom_id           OE1 
_struct_conn.pdbx_ptnr1_label_alt_id       ? 
_struct_conn.pdbx_ptnr1_PDB_ins_code       ? 
_struct_conn.pdbx_ptnr1_standard_comp_id   ? 
_struct_conn.ptnr1_symmetry                1_555 
_struct_conn.ptnr2_label_asym_id           D 
_struct_conn.ptnr2_label_comp_id           K 
_struct_conn.ptnr2_label_seq_id            . 
_struct_conn.ptnr2_label_atom_id           K 
_struct_conn.pdbx_ptnr2_label_alt_id       ? 
_struct_conn.pdbx_ptnr2_PDB_ins_code       ? 
_struct_conn.ptnr1_auth_asym_id            A 
_struct_conn.ptnr1_auth_comp_id            GLU 
_struct_conn.ptnr1_auth_seq_id             379 
_struct_conn.ptnr2_auth_asym_id            A 
_struct_conn.ptnr2_auth_comp_id            K 
_struct_conn.ptnr2_auth_seq_id             902 
_struct_conn.ptnr2_symmetry                1_555 
_struct_conn.pdbx_ptnr3_label_atom_id      ? 
_struct_conn.pdbx_ptnr3_label_seq_id       ? 
_struct_conn.pdbx_ptnr3_label_comp_id      ? 
_struct_conn.pdbx_ptnr3_label_asym_id      ? 
_struct_conn.pdbx_ptnr3_label_alt_id       ? 
_struct_conn.pdbx_ptnr3_PDB_ins_code       ? 
_struct_conn.details                       ? 
_struct_conn.pdbx_dist_value               3.245 
_struct_conn.pdbx_value_order              ? 
_struct_conn.pdbx_role                     ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 ALA 259 A . ? ALA 240 A PRO 260 A ? PRO 241 A 1 2.84  
2 PRO 489 A . ? PRO 470 A PRO 490 A ? PRO 471 A 1 -7.80 
3 GLN 652 A . ? GLN 633 A PRO 653 A ? PRO 634 A 1 2.60  
4 VAL 659 A . ? VAL 640 A PRO 660 A ? PRO 641 A 1 -1.75 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 2 ? 
AA3 ? 3 ? 
AA4 ? 4 ? 
AA5 ? 2 ? 
AA6 ? 5 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA1 2 3 ? parallel      
AA1 3 4 ? parallel      
AA1 4 5 ? parallel      
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? parallel      
AA5 1 2 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
AA6 4 5 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ASP A 602 ? LEU A 605 ? ASP A 583 LEU A 586 
AA1 2 ASP A 322 ? GLU A 327 ? ASP A 303 GLU A 308 
AA1 3 LYS A 299 ? ILE A 303 ? LYS A 280 ILE A 284 
AA1 4 ALA A 639 ? CYS A 642 ? ALA A 620 CYS A 623 
AA1 5 LEU A 815 ? PHE A 817 ? LEU A 796 PHE A 798 
AA2 1 THR A 338 ? LYS A 341 ? THR A 319 LYS A 322 
AA2 2 TYR A 344 ? ASP A 347 ? TYR A 325 ASP A 328 
AA3 1 VAL A 352 ? VAL A 353 ? VAL A 333 VAL A 334 
AA3 2 LEU A 584 ? VAL A 586 ? LEU A 565 VAL A 567 
AA3 3 LEU A 372 ? LYS A 374 ? LEU A 353 LYS A 355 
AA4 1 THR A 632 ? CYS A 637 ? THR A 613 CYS A 618 
AA4 2 GLY A 618 ? ASN A 625 ? GLY A 599 ASN A 606 
AA4 3 THR A 607 ? THR A 615 ? THR A 588 THR A 596 
AA4 4 GLN A 657 ? VAL A 659 ? GLN A 638 VAL A 640 
AA5 1 GLY A 674 ? PHE A 675 ? GLY A 655 PHE A 656 
AA5 2 SER A 781 ? TYR A 782 ? SER A 762 TYR A 763 
AA6 1 LEU A 696 ? GLY A 698 ? LEU A 677 GLY A 679 
AA6 2 LEU A 712 ? TRP A 714 ? LEU A 693 TRP A 695 
AA6 3 ILE A 721 ? VAL A 726 ? ILE A 702 VAL A 707 
AA6 4 ASN A 679 ? CYS A 684 ? ASN A 660 CYS A 665 
AA6 5 GLU A 764 ? VAL A 767 ? GLU A 745 VAL A 748 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O LYS A 604 ? O LYS A 585 N LEU A 325 ? N LEU A 306 
AA1 2 3 O ASP A 322 ? O ASP A 303 N VAL A 300 ? N VAL A 281 
AA1 3 4 N ILE A 301 ? N ILE A 282 O LEU A 641 ? O LEU A 622 
AA1 4 5 N CYS A 642 ? N CYS A 623 O PHE A 816 ? O PHE A 797 
AA2 1 2 N PHE A 339 ? N PHE A 320 O ALA A 346 ? O ALA A 327 
AA3 1 2 N VAL A 353 ? N VAL A 334 O LEU A 584 ? O LEU A 565 
AA3 2 3 O THR A 585 ? O THR A 566 N ALA A 373 ? N ALA A 354 
AA4 1 2 O CYS A 637 ? O CYS A 618 N CYS A 619 ? N CYS A 600 
AA4 2 3 O ILE A 622 ? O ILE A 603 N ARG A 610 ? N ARG A 591 
AA4 3 4 N VAL A 612 ? N VAL A 593 O GLN A 657 ? O GLN A 638 
AA5 1 2 N GLY A 674 ? N GLY A 655 O TYR A 782 ? O TYR A 763 
AA6 1 2 N PHE A 697 ? N PHE A 678 O PHE A 713 ? O PHE A 694 
AA6 2 3 N TRP A 714 ? N TRP A 695 O LEU A 723 ? O LEU A 704 
AA6 3 4 O LEU A 722 ? O LEU A 703 N LEU A 683 ? N LEU A 664 
AA6 4 5 N VAL A 682 ? N VAL A 663 O VAL A 766 ? O VAL A 747 
# 
_pdbx_entry_details.entry_id                   8GJ6 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 NZ A LYS 374 ? ? OD1 A ASP 525 ? ? 1.82 
2 1 NZ A LYS 374 ? ? CG  A ASP 525 ? ? 2.07 
3 1 O  B VAL 321 ? ? OG  B SER 325 ? ? 2.10 
4 1 OG B SER 413 ? ? OE1 B GLN 416 ? ? 2.13 
5 1 O  A ALA 343 ? ? OG  A SER 346 ? ? 2.17 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 ASN A 224 ? ? -164.58 93.99   
2  1 PRO A 274 ? ? -37.39  137.26  
3  1 THR A 335 ? ? -83.50  36.82   
4  1 ASP A 397 ? ? 48.39   29.23   
5  1 ASN A 514 ? ? -113.58 64.91   
6  1 PRO A 516 ? ? -67.76  -174.52 
7  1 THR A 542 ? ? -170.70 148.50  
8  1 THR A 610 ? ? -68.36  0.20    
9  1 LEU A 659 ? ? -172.86 123.48  
10 1 MET A 715 ? ? -67.12  0.36    
11 1 ALA A 757 ? ? -141.58 -56.81  
12 1 TYR A 807 ? ? -142.43 51.05   
13 1 LEU B 316 ? ? -165.87 93.81   
14 1 PRO B 369 ? ? -65.91  2.20    
15 1 PRO B 373 ? ? -58.81  175.08  
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A GLY -18 ? A GLY 1   
2   1 Y 1 A SER -17 ? A SER 2   
3   1 Y 1 A SER -16 ? A SER 3   
4   1 Y 1 A HIS -15 ? A HIS 4   
5   1 Y 1 A HIS -14 ? A HIS 5   
6   1 Y 1 A HIS -13 ? A HIS 6   
7   1 Y 1 A HIS -12 ? A HIS 7   
8   1 Y 1 A HIS -11 ? A HIS 8   
9   1 Y 1 A HIS -10 ? A HIS 9   
10  1 Y 1 A SER -9  ? A SER 10  
11  1 Y 1 A SER -8  ? A SER 11  
12  1 Y 1 A GLY -7  ? A GLY 12  
13  1 Y 1 A LEU -6  ? A LEU 13  
14  1 Y 1 A VAL -5  ? A VAL 14  
15  1 Y 1 A PRO -4  ? A PRO 15  
16  1 Y 1 A ARG -3  ? A ARG 16  
17  1 Y 1 A GLY -2  ? A GLY 17  
18  1 Y 1 A SER -1  ? A SER 18  
19  1 Y 1 A HIS 0   ? A HIS 19  
20  1 Y 1 A MET 1   ? A MET 20  
21  1 Y 1 A LEU 2   ? A LEU 21  
22  1 Y 1 A SER 3   ? A SER 22  
23  1 Y 1 A GLY 4   ? A GLY 23  
24  1 Y 1 A LYS 5   ? A LYS 24  
25  1 Y 1 A LYS 6   ? A LYS 25  
26  1 Y 1 A ALA 7   ? A ALA 26  
27  1 Y 1 A ALA 8   ? A ALA 27  
28  1 Y 1 A ALA 9   ? A ALA 28  
29  1 Y 1 A ALA 10  ? A ALA 29  
30  1 Y 1 A ALA 11  ? A ALA 30  
31  1 Y 1 A ALA 12  ? A ALA 31  
32  1 Y 1 A ALA 13  ? A ALA 32  
33  1 Y 1 A ALA 14  ? A ALA 33  
34  1 Y 1 A ALA 15  ? A ALA 34  
35  1 Y 1 A ALA 16  ? A ALA 35  
36  1 Y 1 A ALA 17  ? A ALA 36  
37  1 Y 1 A ALA 18  ? A ALA 37  
38  1 Y 1 A THR 19  ? A THR 38  
39  1 Y 1 A GLY 20  ? A GLY 39  
40  1 Y 1 A THR 21  ? A THR 40  
41  1 Y 1 A GLU 22  ? A GLU 41  
42  1 Y 1 A ALA 23  ? A ALA 42  
43  1 Y 1 A GLY 24  ? A GLY 43  
44  1 Y 1 A PRO 25  ? A PRO 44  
45  1 Y 1 A GLY 26  ? A GLY 45  
46  1 Y 1 A THR 27  ? A THR 46  
47  1 Y 1 A ALA 28  ? A ALA 47  
48  1 Y 1 A GLY 29  ? A GLY 48  
49  1 Y 1 A GLY 30  ? A GLY 49  
50  1 Y 1 A SER 31  ? A SER 50  
51  1 Y 1 A GLU 32  ? A GLU 51  
52  1 Y 1 A ASN 33  ? A ASN 52  
53  1 Y 1 A GLY 34  ? A GLY 53  
54  1 Y 1 A SER 35  ? A SER 54  
55  1 Y 1 A GLU 36  ? A GLU 55  
56  1 Y 1 A VAL 37  ? A VAL 56  
57  1 Y 1 A ALA 38  ? A ALA 57  
58  1 Y 1 A ALA 39  ? A ALA 58  
59  1 Y 1 A GLN 40  ? A GLN 59  
60  1 Y 1 A PRO 41  ? A PRO 60  
61  1 Y 1 A ALA 42  ? A ALA 61  
62  1 Y 1 A GLY 43  ? A GLY 62  
63  1 Y 1 A LEU 44  ? A LEU 63  
64  1 Y 1 A SER 45  ? A SER 64  
65  1 Y 1 A GLY 46  ? A GLY 65  
66  1 Y 1 A PRO 47  ? A PRO 66  
67  1 Y 1 A ALA 48  ? A ALA 67  
68  1 Y 1 A GLU 49  ? A GLU 68  
69  1 Y 1 A VAL 50  ? A VAL 69  
70  1 Y 1 A GLY 51  ? A GLY 70  
71  1 Y 1 A PRO 52  ? A PRO 71  
72  1 Y 1 A GLY 53  ? A GLY 72  
73  1 Y 1 A ALA 54  ? A ALA 73  
74  1 Y 1 A VAL 55  ? A VAL 74  
75  1 Y 1 A GLY 56  ? A GLY 75  
76  1 Y 1 A GLU 57  ? A GLU 76  
77  1 Y 1 A ARG 58  ? A ARG 77  
78  1 Y 1 A THR 59  ? A THR 78  
79  1 Y 1 A PRO 60  ? A PRO 79  
80  1 Y 1 A ARG 61  ? A ARG 80  
81  1 Y 1 A LYS 62  ? A LYS 81  
82  1 Y 1 A LYS 63  ? A LYS 82  
83  1 Y 1 A GLU 64  ? A GLU 83  
84  1 Y 1 A PRO 65  ? A PRO 84  
85  1 Y 1 A PRO 66  ? A PRO 85  
86  1 Y 1 A ARG 67  ? A ARG 86  
87  1 Y 1 A ALA 68  ? A ALA 87  
88  1 Y 1 A SER 69  ? A SER 88  
89  1 Y 1 A PRO 70  ? A PRO 89  
90  1 Y 1 A PRO 71  ? A PRO 90  
91  1 Y 1 A GLY 72  ? A GLY 91  
92  1 Y 1 A GLY 73  ? A GLY 92  
93  1 Y 1 A LEU 74  ? A LEU 93  
94  1 Y 1 A ALA 75  ? A ALA 94  
95  1 Y 1 A GLU 76  ? A GLU 95  
96  1 Y 1 A PRO 77  ? A PRO 96  
97  1 Y 1 A PRO 78  ? A PRO 97  
98  1 Y 1 A GLY 79  ? A GLY 98  
99  1 Y 1 A SER 80  ? A SER 99  
100 1 Y 1 A ALA 81  ? A ALA 100 
101 1 Y 1 A GLY 82  ? A GLY 101 
102 1 Y 1 A PRO 83  ? A PRO 102 
103 1 Y 1 A GLN 84  ? A GLN 103 
104 1 Y 1 A ALA 85  ? A ALA 104 
105 1 Y 1 A GLY 86  ? A GLY 105 
106 1 Y 1 A PRO 87  ? A PRO 106 
107 1 Y 1 A THR 88  ? A THR 107 
108 1 Y 1 A VAL 89  ? A VAL 108 
109 1 Y 1 A VAL 90  ? A VAL 109 
110 1 Y 1 A PRO 91  ? A PRO 110 
111 1 Y 1 A GLY 92  ? A GLY 111 
112 1 Y 1 A SER 93  ? A SER 112 
113 1 Y 1 A ALA 94  ? A ALA 113 
114 1 Y 1 A THR 95  ? A THR 114 
115 1 Y 1 A PRO 96  ? A PRO 115 
116 1 Y 1 A MET 97  ? A MET 116 
117 1 Y 1 A GLU 98  ? A GLU 117 
118 1 Y 1 A THR 99  ? A THR 118 
119 1 Y 1 A GLY 100 ? A GLY 119 
120 1 Y 1 A ILE 101 ? A ILE 120 
121 1 Y 1 A ALA 102 ? A ALA 121 
122 1 Y 1 A GLU 103 ? A GLU 122 
123 1 Y 1 A THR 104 ? A THR 123 
124 1 Y 1 A PRO 105 ? A PRO 124 
125 1 Y 1 A GLU 106 ? A GLU 125 
126 1 Y 1 A GLY 107 ? A GLY 126 
127 1 Y 1 A ARG 108 ? A ARG 127 
128 1 Y 1 A ARG 109 ? A ARG 128 
129 1 Y 1 A THR 110 ? A THR 129 
130 1 Y 1 A SER 111 ? A SER 130 
131 1 Y 1 A ARG 112 ? A ARG 131 
132 1 Y 1 A ARG 113 ? A ARG 132 
133 1 Y 1 A LYS 114 ? A LYS 133 
134 1 Y 1 A ARG 115 ? A ARG 134 
135 1 Y 1 A ALA 116 ? A ALA 135 
136 1 Y 1 A LYS 117 ? A LYS 136 
137 1 Y 1 A VAL 118 ? A VAL 137 
138 1 Y 1 A GLU 119 ? A GLU 138 
139 1 Y 1 A TYR 120 ? A TYR 139 
140 1 Y 1 A ARG 121 ? A ARG 140 
141 1 Y 1 A GLU 122 ? A GLU 141 
142 1 Y 1 A MET 123 ? A MET 142 
143 1 Y 1 A ASP 124 ? A ASP 143 
144 1 Y 1 A GLU 125 ? A GLU 144 
145 1 Y 1 A SER 126 ? A SER 145 
146 1 Y 1 A LEU 127 ? A LEU 146 
147 1 Y 1 A ALA 128 ? A ALA 147 
148 1 Y 1 A ASN 129 ? A ASN 148 
149 1 Y 1 A LEU 130 ? A LEU 149 
150 1 Y 1 A SER 131 ? A SER 150 
151 1 Y 1 A GLU 132 ? A GLU 151 
152 1 Y 1 A ASP 133 ? A ASP 152 
153 1 Y 1 A GLU 134 ? A GLU 153 
154 1 Y 1 A TYR 135 ? A TYR 154 
155 1 Y 1 A TYR 136 ? A TYR 155 
156 1 Y 1 A SER 137 ? A SER 156 
157 1 Y 1 A GLU 138 ? A GLU 157 
158 1 Y 1 A GLU 139 ? A GLU 158 
159 1 Y 1 A GLU 140 ? A GLU 159 
160 1 Y 1 A ARG 141 ? A ARG 160 
161 1 Y 1 A ASN 142 ? A ASN 161 
162 1 Y 1 A ALA 143 ? A ALA 162 
163 1 Y 1 A LYS 144 ? A LYS 163 
164 1 Y 1 A ALA 145 ? A ALA 164 
165 1 Y 1 A GLU 146 ? A GLU 165 
166 1 Y 1 A LYS 147 ? A LYS 166 
167 1 Y 1 A GLU 148 ? A GLU 167 
168 1 Y 1 A LYS 149 ? A LYS 168 
169 1 Y 1 A LYS 150 ? A LYS 169 
170 1 Y 1 A LEU 151 ? A LEU 170 
171 1 Y 1 A PRO 152 ? A PRO 171 
172 1 Y 1 A PRO 153 ? A PRO 172 
173 1 Y 1 A PRO 154 ? A PRO 173 
174 1 Y 1 A PRO 155 ? A PRO 174 
175 1 Y 1 A PRO 156 ? A PRO 175 
176 1 Y 1 A GLN 157 ? A GLN 176 
177 1 Y 1 A ALA 158 ? A ALA 177 
178 1 Y 1 A PRO 159 ? A PRO 178 
179 1 Y 1 A PRO 160 ? A PRO 179 
180 1 Y 1 A GLU 161 ? A GLU 180 
181 1 Y 1 A GLU 162 ? A GLU 181 
182 1 Y 1 A GLU 163 ? A GLU 182 
183 1 Y 1 A ASN 164 ? A ASN 183 
184 1 Y 1 A GLU 165 ? A GLU 184 
185 1 Y 1 A SER 166 ? A SER 185 
186 1 Y 1 A GLU 167 ? A GLU 186 
187 1 Y 1 A PRO 168 ? A PRO 187 
188 1 Y 1 A GLU 169 ? A GLU 188 
189 1 Y 1 A GLU 170 ? A GLU 189 
190 1 Y 1 A PRO 837 ? A PRO 856 
191 1 Y 1 A ARG 838 ? A ARG 857 
192 1 Y 1 A GLN 839 ? A GLN 858 
193 1 Y 1 A ALA 840 ? A ALA 859 
194 1 Y 1 A THR 841 ? A THR 860 
195 1 Y 1 A PRO 842 ? A PRO 861 
196 1 Y 1 A GLY 843 ? A GLY 862 
197 1 Y 1 A VAL 844 ? A VAL 863 
198 1 Y 1 A PRO 845 ? A PRO 864 
199 1 Y 1 A ALA 846 ? A ALA 865 
200 1 Y 1 A GLN 847 ? A GLN 866 
201 1 Y 1 A GLN 848 ? A GLN 867 
202 1 Y 1 A SER 849 ? A SER 868 
203 1 Y 1 A PRO 850 ? A PRO 869 
204 1 Y 1 A SER 851 ? A SER 870 
205 1 Y 1 A MET 852 ? A MET 871 
206 1 Y 1 B GLY 297 ? B GLY 1   
207 1 Y 1 B PRO 298 ? B PRO 2   
208 1 Y 1 B LEU 299 ? B LEU 3   
209 1 Y 1 B GLY 300 ? B GLY 4   
210 1 Y 1 B SER 301 ? B SER 5   
211 1 Y 1 B PRO 302 ? B PRO 6   
212 1 Y 1 B GLU 303 ? B GLU 7   
213 1 Y 1 B PHE 304 ? B PHE 8   
214 1 Y 1 B ARG 305 ? B ARG 9   
215 1 Y 1 B ALA 306 ? B ALA 10  
216 1 Y 1 B LYS 307 ? B LYS 11  
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
K   K    K N N 180 
LEU N    N N N 181 
LEU CA   C N S 182 
LEU C    C N N 183 
LEU O    O N N 184 
LEU CB   C N N 185 
LEU CG   C N N 186 
LEU CD1  C N N 187 
LEU CD2  C N N 188 
LEU OXT  O N N 189 
LEU H    H N N 190 
LEU H2   H N N 191 
LEU HA   H N N 192 
LEU HB2  H N N 193 
LEU HB3  H N N 194 
LEU HG   H N N 195 
LEU HD11 H N N 196 
LEU HD12 H N N 197 
LEU HD13 H N N 198 
LEU HD21 H N N 199 
LEU HD22 H N N 200 
LEU HD23 H N N 201 
LEU HXT  H N N 202 
LYS N    N N N 203 
LYS CA   C N S 204 
LYS C    C N N 205 
LYS O    O N N 206 
LYS CB   C N N 207 
LYS CG   C N N 208 
LYS CD   C N N 209 
LYS CE   C N N 210 
LYS NZ   N N N 211 
LYS OXT  O N N 212 
LYS H    H N N 213 
LYS H2   H N N 214 
LYS HA   H N N 215 
LYS HB2  H N N 216 
LYS HB3  H N N 217 
LYS HG2  H N N 218 
LYS HG3  H N N 219 
LYS HD2  H N N 220 
LYS HD3  H N N 221 
LYS HE2  H N N 222 
LYS HE3  H N N 223 
LYS HZ1  H N N 224 
LYS HZ2  H N N 225 
LYS HZ3  H N N 226 
LYS HXT  H N N 227 
MET N    N N N 228 
MET CA   C N S 229 
MET C    C N N 230 
MET O    O N N 231 
MET CB   C N N 232 
MET CG   C N N 233 
MET SD   S N N 234 
MET CE   C N N 235 
MET OXT  O N N 236 
MET H    H N N 237 
MET H2   H N N 238 
MET HA   H N N 239 
MET HB2  H N N 240 
MET HB3  H N N 241 
MET HG2  H N N 242 
MET HG3  H N N 243 
MET HE1  H N N 244 
MET HE2  H N N 245 
MET HE3  H N N 246 
MET HXT  H N N 247 
PHE N    N N N 248 
PHE CA   C N S 249 
PHE C    C N N 250 
PHE O    O N N 251 
PHE CB   C N N 252 
PHE CG   C Y N 253 
PHE CD1  C Y N 254 
PHE CD2  C Y N 255 
PHE CE1  C Y N 256 
PHE CE2  C Y N 257 
PHE CZ   C Y N 258 
PHE OXT  O N N 259 
PHE H    H N N 260 
PHE H2   H N N 261 
PHE HA   H N N 262 
PHE HB2  H N N 263 
PHE HB3  H N N 264 
PHE HD1  H N N 265 
PHE HD2  H N N 266 
PHE HE1  H N N 267 
PHE HE2  H N N 268 
PHE HZ   H N N 269 
PHE HXT  H N N 270 
PRO N    N N N 271 
PRO CA   C N S 272 
PRO C    C N N 273 
PRO O    O N N 274 
PRO CB   C N N 275 
PRO CG   C N N 276 
PRO CD   C N N 277 
PRO OXT  O N N 278 
PRO H    H N N 279 
PRO HA   H N N 280 
PRO HB2  H N N 281 
PRO HB3  H N N 282 
PRO HG2  H N N 283 
PRO HG3  H N N 284 
PRO HD2  H N N 285 
PRO HD3  H N N 286 
PRO HXT  H N N 287 
SER N    N N N 288 
SER CA   C N S 289 
SER C    C N N 290 
SER O    O N N 291 
SER CB   C N N 292 
SER OG   O N N 293 
SER OXT  O N N 294 
SER H    H N N 295 
SER H2   H N N 296 
SER HA   H N N 297 
SER HB2  H N N 298 
SER HB3  H N N 299 
SER HG   H N N 300 
SER HXT  H N N 301 
THR N    N N N 302 
THR CA   C N S 303 
THR C    C N N 304 
THR O    O N N 305 
THR CB   C N R 306 
THR OG1  O N N 307 
THR CG2  C N N 308 
THR OXT  O N N 309 
THR H    H N N 310 
THR H2   H N N 311 
THR HA   H N N 312 
THR HB   H N N 313 
THR HG1  H N N 314 
THR HG21 H N N 315 
THR HG22 H N N 316 
THR HG23 H N N 317 
THR HXT  H N N 318 
TRP N    N N N 319 
TRP CA   C N S 320 
TRP C    C N N 321 
TRP O    O N N 322 
TRP CB   C N N 323 
TRP CG   C Y N 324 
TRP CD1  C Y N 325 
TRP CD2  C Y N 326 
TRP NE1  N Y N 327 
TRP CE2  C Y N 328 
TRP CE3  C Y N 329 
TRP CZ2  C Y N 330 
TRP CZ3  C Y N 331 
TRP CH2  C Y N 332 
TRP OXT  O N N 333 
TRP H    H N N 334 
TRP H2   H N N 335 
TRP HA   H N N 336 
TRP HB2  H N N 337 
TRP HB3  H N N 338 
TRP HD1  H N N 339 
TRP HE1  H N N 340 
TRP HE3  H N N 341 
TRP HZ2  H N N 342 
TRP HZ3  H N N 343 
TRP HH2  H N N 344 
TRP HXT  H N N 345 
TYR N    N N N 346 
TYR CA   C N S 347 
TYR C    C N N 348 
TYR O    O N N 349 
TYR CB   C N N 350 
TYR CG   C Y N 351 
TYR CD1  C Y N 352 
TYR CD2  C Y N 353 
TYR CE1  C Y N 354 
TYR CE2  C Y N 355 
TYR CZ   C Y N 356 
TYR OH   O N N 357 
TYR OXT  O N N 358 
TYR H    H N N 359 
TYR H2   H N N 360 
TYR HA   H N N 361 
TYR HB2  H N N 362 
TYR HB3  H N N 363 
TYR HD1  H N N 364 
TYR HD2  H N N 365 
TYR HE1  H N N 366 
TYR HE2  H N N 367 
TYR HH   H N N 368 
TYR HXT  H N N 369 
VAL N    N N N 370 
VAL CA   C N S 371 
VAL C    C N N 372 
VAL O    O N N 373 
VAL CB   C N N 374 
VAL CG1  C N N 375 
VAL CG2  C N N 376 
VAL OXT  O N N 377 
VAL H    H N N 378 
VAL H2   H N N 379 
VAL HA   H N N 380 
VAL HB   H N N 381 
VAL HG11 H N N 382 
VAL HG12 H N N 383 
VAL HG13 H N N 384 
VAL HG21 H N N 385 
VAL HG22 H N N 386 
VAL HG23 H N N 387 
VAL HXT  H N N 388 
ZSI C4   C Y N 389 
ZSI C14  C N N 390 
ZSI C5   C Y N 391 
ZSI C6   C Y N 392 
ZSI C11  C Y N 393 
ZSI C7   C Y N 394 
ZSI C8   C N S 395 
ZSI C9   C N N 396 
ZSI C10  C N R 397 
ZSI C12  C Y N 398 
ZSI C13  C Y N 399 
ZSI N1   N N N 400 
ZSI N2   N N N 401 
ZSI C3   C Y N 402 
ZSI N3   N N N 403 
ZSI C1   C N N 404 
ZSI C15  C Y N 405 
ZSI C16  C N N 406 
ZSI C17  C Y N 407 
ZSI C18  C Y N 408 
ZSI C19  C N N 409 
ZSI C2   C N N 410 
ZSI C20  C N S 411 
ZSI C21  C N S 412 
ZSI C22  C N R 413 
ZSI C23  C N N 414 
ZSI C24  C N N 415 
ZSI C25  C N R 416 
ZSI C26  C N R 417 
ZSI C27  C Y N 418 
ZSI C28  C Y N 419 
ZSI C29  C Y N 420 
ZSI C30  C Y N 421 
ZSI C31  C Y N 422 
ZSI C32  C N R 423 
ZSI C33  C N S 424 
ZSI C34  C N N 425 
ZSI C35  C N N 426 
ZSI C36  C N N 427 
ZSI C37  C N S 428 
ZSI C38  C Y N 429 
ZSI N10  N N N 430 
ZSI N4   N Y N 431 
ZSI N5   N Y N 432 
ZSI N6   N N N 433 
ZSI N7   N Y N 434 
ZSI N8   N Y N 435 
ZSI N9   N N N 436 
ZSI O1   O N N 437 
ZSI O10  O N N 438 
ZSI O11  O N N 439 
ZSI O12  O N N 440 
ZSI O13  O N N 441 
ZSI O14  O N N 442 
ZSI O15  O N N 443 
ZSI O16  O N N 444 
ZSI O17  O N N 445 
ZSI O2   O N N 446 
ZSI O3   O N N 447 
ZSI O4   O N N 448 
ZSI O5   O N N 449 
ZSI O6   O N N 450 
ZSI O7   O N N 451 
ZSI O8   O N N 452 
ZSI O9   O N N 453 
ZSI P1   P N N 454 
ZSI P2   P N N 455 
ZSI H1   H N N 456 
ZSI H2   H N N 457 
ZSI H3   H N N 458 
ZSI H4   H N N 459 
ZSI H5   H N N 460 
ZSI H6   H N N 461 
ZSI H7   H N N 462 
ZSI H8   H N N 463 
ZSI H9   H N N 464 
ZSI H10  H N N 465 
ZSI H11  H N N 466 
ZSI H12  H N N 467 
ZSI H13  H N N 468 
ZSI H14  H N N 469 
ZSI H15  H N N 470 
ZSI H16  H N N 471 
ZSI H17  H N N 472 
ZSI H18  H N N 473 
ZSI H19  H N N 474 
ZSI H20  H N N 475 
ZSI H21  H N N 476 
ZSI H22  H N N 477 
ZSI H23  H N N 478 
ZSI H24  H N N 479 
ZSI H25  H N N 480 
ZSI H26  H N N 481 
ZSI H27  H N N 482 
ZSI H28  H N N 483 
ZSI H29  H N N 484 
ZSI H30  H N N 485 
ZSI H31  H N N 486 
ZSI H32  H N N 487 
ZSI H33  H N N 488 
ZSI H34  H N N 489 
ZSI H36  H N N 490 
ZSI H37  H N N 491 
ZSI H38  H N N 492 
ZSI H39  H N N 493 
ZSI H41  H N N 494 
ZSI H42  H N N 495 
ZSI H43  H N N 496 
ZSI H44  H N N 497 
ZSI H45  H N N 498 
ZSI H46  H N N 499 
ZSI H47  H N N 500 
ZSI H48  H N N 501 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
PHE N   CA   sing N N 235 
PHE N   H    sing N N 236 
PHE N   H2   sing N N 237 
PHE CA  C    sing N N 238 
PHE CA  CB   sing N N 239 
PHE CA  HA   sing N N 240 
PHE C   O    doub N N 241 
PHE C   OXT  sing N N 242 
PHE CB  CG   sing N N 243 
PHE CB  HB2  sing N N 244 
PHE CB  HB3  sing N N 245 
PHE CG  CD1  doub Y N 246 
PHE CG  CD2  sing Y N 247 
PHE CD1 CE1  sing Y N 248 
PHE CD1 HD1  sing N N 249 
PHE CD2 CE2  doub Y N 250 
PHE CD2 HD2  sing N N 251 
PHE CE1 CZ   doub Y N 252 
PHE CE1 HE1  sing N N 253 
PHE CE2 CZ   sing Y N 254 
PHE CE2 HE2  sing N N 255 
PHE CZ  HZ   sing N N 256 
PHE OXT HXT  sing N N 257 
PRO N   CA   sing N N 258 
PRO N   CD   sing N N 259 
PRO N   H    sing N N 260 
PRO CA  C    sing N N 261 
PRO CA  CB   sing N N 262 
PRO CA  HA   sing N N 263 
PRO C   O    doub N N 264 
PRO C   OXT  sing N N 265 
PRO CB  CG   sing N N 266 
PRO CB  HB2  sing N N 267 
PRO CB  HB3  sing N N 268 
PRO CG  CD   sing N N 269 
PRO CG  HG2  sing N N 270 
PRO CG  HG3  sing N N 271 
PRO CD  HD2  sing N N 272 
PRO CD  HD3  sing N N 273 
PRO OXT HXT  sing N N 274 
SER N   CA   sing N N 275 
SER N   H    sing N N 276 
SER N   H2   sing N N 277 
SER CA  C    sing N N 278 
SER CA  CB   sing N N 279 
SER CA  HA   sing N N 280 
SER C   O    doub N N 281 
SER C   OXT  sing N N 282 
SER CB  OG   sing N N 283 
SER CB  HB2  sing N N 284 
SER CB  HB3  sing N N 285 
SER OG  HG   sing N N 286 
SER OXT HXT  sing N N 287 
THR N   CA   sing N N 288 
THR N   H    sing N N 289 
THR N   H2   sing N N 290 
THR CA  C    sing N N 291 
THR CA  CB   sing N N 292 
THR CA  HA   sing N N 293 
THR C   O    doub N N 294 
THR C   OXT  sing N N 295 
THR CB  OG1  sing N N 296 
THR CB  CG2  sing N N 297 
THR CB  HB   sing N N 298 
THR OG1 HG1  sing N N 299 
THR CG2 HG21 sing N N 300 
THR CG2 HG22 sing N N 301 
THR CG2 HG23 sing N N 302 
THR OXT HXT  sing N N 303 
TRP N   CA   sing N N 304 
TRP N   H    sing N N 305 
TRP N   H2   sing N N 306 
TRP CA  C    sing N N 307 
TRP CA  CB   sing N N 308 
TRP CA  HA   sing N N 309 
TRP C   O    doub N N 310 
TRP C   OXT  sing N N 311 
TRP CB  CG   sing N N 312 
TRP CB  HB2  sing N N 313 
TRP CB  HB3  sing N N 314 
TRP CG  CD1  doub Y N 315 
TRP CG  CD2  sing Y N 316 
TRP CD1 NE1  sing Y N 317 
TRP CD1 HD1  sing N N 318 
TRP CD2 CE2  doub Y N 319 
TRP CD2 CE3  sing Y N 320 
TRP NE1 CE2  sing Y N 321 
TRP NE1 HE1  sing N N 322 
TRP CE2 CZ2  sing Y N 323 
TRP CE3 CZ3  doub Y N 324 
TRP CE3 HE3  sing N N 325 
TRP CZ2 CH2  doub Y N 326 
TRP CZ2 HZ2  sing N N 327 
TRP CZ3 CH2  sing Y N 328 
TRP CZ3 HZ3  sing N N 329 
TRP CH2 HH2  sing N N 330 
TRP OXT HXT  sing N N 331 
TYR N   CA   sing N N 332 
TYR N   H    sing N N 333 
TYR N   H2   sing N N 334 
TYR CA  C    sing N N 335 
TYR CA  CB   sing N N 336 
TYR CA  HA   sing N N 337 
TYR C   O    doub N N 338 
TYR C   OXT  sing N N 339 
TYR CB  CG   sing N N 340 
TYR CB  HB2  sing N N 341 
TYR CB  HB3  sing N N 342 
TYR CG  CD1  doub Y N 343 
TYR CG  CD2  sing Y N 344 
TYR CD1 CE1  sing Y N 345 
TYR CD1 HD1  sing N N 346 
TYR CD2 CE2  doub Y N 347 
TYR CD2 HD2  sing N N 348 
TYR CE1 CZ   doub Y N 349 
TYR CE1 HE1  sing N N 350 
TYR CE2 CZ   sing Y N 351 
TYR CE2 HE2  sing N N 352 
TYR CZ  OH   sing N N 353 
TYR OH  HH   sing N N 354 
TYR OXT HXT  sing N N 355 
VAL N   CA   sing N N 356 
VAL N   H    sing N N 357 
VAL N   H2   sing N N 358 
VAL CA  C    sing N N 359 
VAL CA  CB   sing N N 360 
VAL CA  HA   sing N N 361 
VAL C   O    doub N N 362 
VAL C   OXT  sing N N 363 
VAL CB  CG1  sing N N 364 
VAL CB  CG2  sing N N 365 
VAL CB  HB   sing N N 366 
VAL CG1 HG11 sing N N 367 
VAL CG1 HG12 sing N N 368 
VAL CG1 HG13 sing N N 369 
VAL CG2 HG21 sing N N 370 
VAL CG2 HG22 sing N N 371 
VAL CG2 HG23 sing N N 372 
VAL OXT HXT  sing N N 373 
ZSI C14 C13  sing N N 374 
ZSI O2  C10  sing N N 375 
ZSI C13 C12  doub Y N 376 
ZSI C13 C15  sing Y N 377 
ZSI C12 C11  sing Y N 378 
ZSI C10 C9   sing N N 379 
ZSI C10 N2   sing N N 380 
ZSI C9  C8   sing N N 381 
ZSI C16 C15  sing N N 382 
ZSI C15 C17  doub Y N 383 
ZSI C11 N2   sing N N 384 
ZSI C11 C18  doub Y N 385 
ZSI N2  C37  sing N N 386 
ZSI O17 C36  doub N N 387 
ZSI C8  C37  sing N N 388 
ZSI C8  C7   sing N N 389 
ZSI C17 C18  sing Y N 390 
ZSI C18 N3   sing N N 391 
ZSI C37 C36  sing N N 392 
ZSI C37 C34  sing N N 393 
ZSI C36 N10  sing N N 394 
ZSI C7  C6   doub Y N 395 
ZSI C7  C38  sing Y N 396 
ZSI C6  C5   sing Y N 397 
ZSI C38 C3   doub Y N 398 
ZSI N3  C34  sing N N 399 
ZSI N3  C19  sing N N 400 
ZSI C34 N9   doub N N 401 
ZSI N10 C35  sing N N 402 
ZSI C5  C4   doub Y N 403 
ZSI C3  C4   sing Y N 404 
ZSI C3  C2   sing N N 405 
ZSI O3  C20  sing N N 406 
ZSI N1  C2   sing N N 407 
ZSI N1  C1   sing N N 408 
ZSI C19 C20  sing N N 409 
ZSI N9  C35  sing N N 410 
ZSI C2  O1   doub N N 411 
ZSI C35 O16  doub N N 412 
ZSI C20 C21  sing N N 413 
ZSI O14 C32  sing N N 414 
ZSI C21 O4   sing N N 415 
ZSI C21 C22  sing N N 416 
ZSI C32 C33  sing N N 417 
ZSI C32 C26  sing N N 418 
ZSI O10 P2   doub N N 419 
ZSI O5  C22  sing N N 420 
ZSI C27 N5   doub Y N 421 
ZSI C27 N4   sing Y N 422 
ZSI C33 O15  sing N N 423 
ZSI C33 C25  sing N N 424 
ZSI N5  C28  sing Y N 425 
ZSI C22 C23  sing N N 426 
ZSI O11 P2   sing N N 427 
ZSI N4  C26  sing N N 428 
ZSI N4  C31  sing Y N 429 
ZSI P2  O12  sing N N 430 
ZSI P2  O9   sing N N 431 
ZSI C26 O13  sing N N 432 
ZSI C28 C31  doub Y N 433 
ZSI C28 C29  sing Y N 434 
ZSI C23 O6   sing N N 435 
ZSI N6  C29  sing N N 436 
ZSI C31 N8   sing Y N 437 
ZSI C29 N7   doub Y N 438 
ZSI O12 C24  sing N N 439 
ZSI C25 O13  sing N N 440 
ZSI C25 C24  sing N N 441 
ZSI O6  P1   sing N N 442 
ZSI O9  P1   sing N N 443 
ZSI N8  C30  doub Y N 444 
ZSI N7  C30  sing Y N 445 
ZSI P1  O8   doub N N 446 
ZSI P1  O7   sing N N 447 
ZSI C4  H1   sing N N 448 
ZSI C14 H2   sing N N 449 
ZSI C14 H3   sing N N 450 
ZSI C14 H4   sing N N 451 
ZSI C5  H5   sing N N 452 
ZSI C6  H6   sing N N 453 
ZSI C8  H7   sing N N 454 
ZSI C9  H8   sing N N 455 
ZSI C9  H9   sing N N 456 
ZSI C10 H10  sing N N 457 
ZSI C12 H11  sing N N 458 
ZSI N1  H12  sing N N 459 
ZSI C1  H13  sing N N 460 
ZSI C1  H14  sing N N 461 
ZSI C1  H15  sing N N 462 
ZSI C16 H16  sing N N 463 
ZSI C16 H17  sing N N 464 
ZSI C16 H18  sing N N 465 
ZSI C17 H19  sing N N 466 
ZSI C19 H20  sing N N 467 
ZSI C19 H21  sing N N 468 
ZSI C20 H22  sing N N 469 
ZSI C21 H23  sing N N 470 
ZSI C22 H24  sing N N 471 
ZSI C23 H25  sing N N 472 
ZSI C23 H26  sing N N 473 
ZSI C24 H27  sing N N 474 
ZSI C24 H28  sing N N 475 
ZSI C25 H29  sing N N 476 
ZSI C26 H30  sing N N 477 
ZSI C27 H31  sing N N 478 
ZSI C30 H32  sing N N 479 
ZSI C32 H33  sing N N 480 
ZSI C33 H34  sing N N 481 
ZSI C38 H36  sing N N 482 
ZSI N10 H37  sing N N 483 
ZSI N6  H38  sing N N 484 
ZSI N6  H39  sing N N 485 
ZSI O11 H41  sing N N 486 
ZSI O14 H42  sing N N 487 
ZSI O15 H43  sing N N 488 
ZSI O2  H44  sing N N 489 
ZSI O3  H45  sing N N 490 
ZSI O4  H46  sing N N 491 
ZSI O5  H47  sing N N 492 
ZSI O7  H48  sing N N 493 
# 
_pdbx_audit_support.funding_organization   'Italian Association for Cancer Research' 
_pdbx_audit_support.country                Italy 
_pdbx_audit_support.grant_number           IG19808 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   2v1d 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    8GJ6 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.008449 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.005597 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.004256 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
K 
N 
O 
P 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . PRO A 1 190 ? -16.379 38.214  98.576  1.00 130.96 ?  171 PRO A N   1 
ATOM   2    C CA  . PRO A 1 190 ? -16.505 38.307  100.041 1.00 128.69 ?  171 PRO A CA  1 
ATOM   3    C C   . PRO A 1 190 ? -17.878 38.858  100.516 1.00 128.51 ?  171 PRO A C   1 
ATOM   4    O O   . PRO A 1 190 ? -18.416 39.785  99.881  1.00 125.36 ?  171 PRO A O   1 
ATOM   5    C CB  . PRO A 1 190 ? -15.353 39.252  100.424 1.00 112.83 ?  171 PRO A CB  1 
ATOM   6    C CG  . PRO A 1 190 ? -14.304 39.010  99.363  1.00 109.38 ?  171 PRO A CG  1 
ATOM   7    C CD  . PRO A 1 190 ? -15.083 38.731  98.088  1.00 122.79 ?  171 PRO A CD  1 
ATOM   8    N N   . SER A 1 191 ? -18.421 38.293  101.610 1.00 125.49 ?  172 SER A N   1 
ATOM   9    C CA  . SER A 1 191 ? -19.762 38.612  102.105 1.00 122.10 ?  172 SER A CA  1 
ATOM   10   C C   . SER A 1 191 ? -19.747 38.821  103.620 1.00 117.10 ?  172 SER A C   1 
ATOM   11   O O   . SER A 1 191 ? -18.897 38.288  104.347 1.00 118.26 ?  172 SER A O   1 
ATOM   12   C CB  . SER A 1 191 ? -20.788 37.509  101.750 1.00 121.86 ?  172 SER A CB  1 
ATOM   13   O OG  . SER A 1 191 ? -20.590 36.308  102.499 1.00 111.27 ?  172 SER A OG  1 
ATOM   14   N N   . GLY A 1 192 ? -20.725 39.592  104.094 1.00 105.90 ?  173 GLY A N   1 
ATOM   15   C CA  . GLY A 1 192 ? -20.884 39.807  105.520 1.00 112.50 ?  173 GLY A CA  1 
ATOM   16   C C   . GLY A 1 192 ? -20.203 41.065  106.022 1.00 110.76 ?  173 GLY A C   1 
ATOM   17   O O   . GLY A 1 192 ? -20.044 42.037  105.271 1.00 102.76 ?  173 GLY A O   1 
ATOM   18   N N   . VAL A 1 193 ? -19.810 41.075  107.300 1.00 107.95 ?  174 VAL A N   1 
ATOM   19   C CA  . VAL A 1 193 ? -18.959 42.167  107.751 1.00 98.99  ?  174 VAL A CA  1 
ATOM   20   C C   . VAL A 1 193 ? -17.597 42.050  107.092 1.00 100.64 ?  174 VAL A C   1 
ATOM   21   O O   . VAL A 1 193 ? -16.928 43.061  106.865 1.00 103.71 ?  174 VAL A O   1 
ATOM   22   C CB  . VAL A 1 193 ? -18.833 42.223  109.291 1.00 96.23  ?  174 VAL A CB  1 
ATOM   23   C CG1 . VAL A 1 193 ? -20.202 42.287  109.953 1.00 95.87  ?  174 VAL A CG1 1 
ATOM   24   C CG2 . VAL A 1 193 ? -17.970 41.079  109.842 1.00 94.06  ?  174 VAL A CG2 1 
ATOM   25   N N   . GLU A 1 194 ? -17.175 40.829  106.749 1.00 101.71 ?  175 GLU A N   1 
ATOM   26   C CA  . GLU A 1 194 ? -15.896 40.636  106.068 1.00 103.58 ?  175 GLU A CA  1 
ATOM   27   C C   . GLU A 1 194 ? -15.874 41.314  104.695 1.00 103.21 ?  175 GLU A C   1 
ATOM   28   O O   . GLU A 1 194 ? -14.829 41.810  104.251 1.00 97.51  ?  175 GLU A O   1 
ATOM   29   C CB  . GLU A 1 194 ? -15.626 39.145  105.918 1.00 112.06 ?  175 GLU A CB  1 
ATOM   30   C CG  . GLU A 1 194 ? -15.784 38.346  107.193 1.00 115.00 ?  175 GLU A CG  1 
ATOM   31   C CD  . GLU A 1 194 ? -15.214 36.947  107.046 1.00 124.35 ?  175 GLU A CD  1 
ATOM   32   O OE1 . GLU A 1 194 ? -14.783 36.601  105.916 1.00 122.98 ?  175 GLU A OE1 1 
ATOM   33   O OE2 . GLU A 1 194 ? -15.192 36.198  108.051 1.00 124.16 ?  175 GLU A OE2 1 
ATOM   34   N N   . GLY A 1 195 ? -17.010 41.320  103.993 1.00 103.53 ?  176 GLY A N   1 
ATOM   35   C CA  . GLY A 1 195 ? -17.058 41.980  102.703 1.00 96.72  ?  176 GLY A CA  1 
ATOM   36   C C   . GLY A 1 195 ? -17.010 43.481  102.834 1.00 92.98  ?  176 GLY A C   1 
ATOM   37   O O   . GLY A 1 195 ? -16.528 44.176  101.932 1.00 89.75  ?  176 GLY A O   1 
ATOM   38   N N   . ALA A 1 196 ? -17.500 44.003  103.960 1.00 98.48  ?  177 ALA A N   1 
ATOM   39   C CA  . ALA A 1 196 ? -17.379 45.430  104.233 1.00 89.53  ?  177 ALA A CA  1 
ATOM   40   C C   . ALA A 1 196 ? -15.918 45.856  104.306 1.00 82.08  ?  177 ALA A C   1 
ATOM   41   O O   . ALA A 1 196 ? -15.542 46.882  103.734 1.00 84.21  ?  177 ALA A O   1 
ATOM   42   C CB  . ALA A 1 196 ? -18.113 45.773  105.525 1.00 87.66  ?  177 ALA A CB  1 
ATOM   43   N N   . ALA A 1 197 ? -15.071 45.073  104.986 1.00 81.43  ?  178 ALA A N   1 
ATOM   44   C CA  . ALA A 1 197 ? -13.650 45.416  105.055 1.00 84.23  ?  178 ALA A CA  1 
ATOM   45   C C   . ALA A 1 197 ? -12.995 45.358  103.679 1.00 84.65  ?  178 ALA A C   1 
ATOM   46   O O   . ALA A 1 197 ? -12.209 46.242  103.312 1.00 80.11  ?  178 ALA A O   1 
ATOM   47   C CB  . ALA A 1 197 ? -12.916 44.495  106.032 1.00 78.89  ?  178 ALA A CB  1 
ATOM   48   N N   . PHE A 1 198 ? -13.299 44.321  102.905 1.00 86.83  ?  179 PHE A N   1 
ATOM   49   C CA  . PHE A 1 198 ? -12.731 44.215  101.570 1.00 84.15  ?  179 PHE A CA  1 
ATOM   50   C C   . PHE A 1 198 ? -13.110 45.434  100.719 1.00 80.22  ?  179 PHE A C   1 
ATOM   51   O O   . PHE A 1 198 ? -12.246 46.069  100.094 1.00 73.12  ?  179 PHE A O   1 
ATOM   52   C CB  . PHE A 1 198 ? -13.188 42.891  100.937 1.00 79.74  ?  179 PHE A CB  1 
ATOM   53   C CG  . PHE A 1 198 ? -12.811 42.751  99.507  1.00 78.06  ?  179 PHE A CG  1 
ATOM   54   C CD1 . PHE A 1 198 ? -11.577 42.234  99.162  1.00 77.56  ?  179 PHE A CD1 1 
ATOM   55   C CD2 . PHE A 1 198 ? -13.684 43.161  98.506  1.00 78.49  ?  179 PHE A CD2 1 
ATOM   56   C CE1 . PHE A 1 198 ? -11.214 42.126  97.841  1.00 80.81  ?  179 PHE A CE1 1 
ATOM   57   C CE2 . PHE A 1 198 ? -13.335 43.074  97.184  1.00 77.13  ?  179 PHE A CE2 1 
ATOM   58   C CZ  . PHE A 1 198 ? -12.100 42.555  96.840  1.00 82.73  ?  179 PHE A CZ  1 
ATOM   59   N N   . GLN A 1 199 ? -14.399 45.786  100.701 1.00 77.26  ?  180 GLN A N   1 
ATOM   60   C CA  . GLN A 1 199 ? -14.887 46.905  99.900  1.00 78.46  ?  180 GLN A CA  1 
ATOM   61   C C   . GLN A 1 199 ? -14.341 48.250  100.377 1.00 83.70  ?  180 GLN A C   1 
ATOM   62   O O   . GLN A 1 199 ? -14.538 49.268  99.700  1.00 81.72  ?  180 GLN A O   1 
ATOM   63   C CB  . GLN A 1 199 ? -16.421 46.887  99.931  1.00 80.65  ?  180 GLN A CB  1 
ATOM   64   C CG  . GLN A 1 199 ? -17.188 47.811  98.955  1.00 92.65  ?  180 GLN A CG  1 
ATOM   65   C CD  . GLN A 1 199 ? -16.920 47.552  97.452  1.00 100.22 ?  180 GLN A CD  1 
ATOM   66   O OE1 . GLN A 1 199 ? -15.828 47.827  96.935  1.00 93.51  ?  180 GLN A OE1 1 
ATOM   67   N NE2 . GLN A 1 199 ? -17.927 47.008  96.753  1.00 103.68 ?  180 GLN A NE2 1 
ATOM   68   N N   . SER A 1 200 ? -13.657 48.274  101.524 1.00 86.79  ?  181 SER A N   1 
ATOM   69   C CA  . SER A 1 200 ? -13.002 49.458  102.069 1.00 78.38  ?  181 SER A CA  1 
ATOM   70   C C   . SER A 1 200 ? -11.479 49.330  102.041 1.00 72.49  ?  181 SER A C   1 
ATOM   71   O O   . SER A 1 200 ? -10.782 50.031  102.769 1.00 75.79  ?  181 SER A O   1 
ATOM   72   C CB  . SER A 1 200 ? -13.499 49.697  103.496 1.00 77.54  ?  181 SER A CB  1 
ATOM   73   O OG  . SER A 1 200 ? -14.912 49.780  103.524 1.00 74.99  ?  181 SER A OG  1 
ATOM   74   N N   . ARG A 1 201 ? -10.959 48.419  101.231 1.00 74.25  ?  182 ARG A N   1 
ATOM   75   C CA  . ARG A 1 201 ? -9.526  48.186  101.098 1.00 66.70  ?  182 ARG A CA  1 
ATOM   76   C C   . ARG A 1 201 ? -8.859  47.897  102.445 1.00 70.03  ?  182 ARG A C   1 
ATOM   77   O O   . ARG A 1 201 ? -7.705  48.253  102.681 1.00 71.13  ?  182 ARG A O   1 
ATOM   78   C CB  . ARG A 1 201 ? -8.879  49.354  100.366 1.00 66.27  ?  182 ARG A CB  1 
ATOM   79   C CG  . ARG A 1 201 ? -9.693  49.760  99.136  1.00 68.58  ?  182 ARG A CG  1 
ATOM   80   C CD  . ARG A 1 201 ? -9.548  51.224  98.819  1.00 64.69  ?  182 ARG A CD  1 
ATOM   81   N NE  . ARG A 1 201 ? -10.156 52.074  99.848  1.00 72.85  ?  182 ARG A NE  1 
ATOM   82   C CZ  . ARG A 1 201 ? -11.429 52.456  99.834  1.00 75.58  ?  182 ARG A CZ  1 
ATOM   83   N NH1 . ARG A 1 201 ? -12.218 52.075  98.841  1.00 79.42  ?  182 ARG A NH1 1 
ATOM   84   N NH2 . ARG A 1 201 ? -11.915 53.220  100.799 1.00 77.03  ?  182 ARG A NH2 1 
ATOM   85   N N   . LEU A 1 202 ? -9.566  47.161  103.316 1.00 77.75  ?  183 LEU A N   1 
ATOM   86   C CA  . LEU A 1 202 ? -9.075  46.833  104.655 1.00 75.08  ?  183 LEU A CA  1 
ATOM   87   C C   . LEU A 1 202 ? -9.053  45.334  104.903 1.00 76.34  ?  183 LEU A C   1 
ATOM   88   O O   . LEU A 1 202 ? -9.999  44.630  104.535 1.00 82.28  ?  183 LEU A O   1 
ATOM   89   C CB  . LEU A 1 202 ? -9.951  47.480  105.735 1.00 77.63  ?  183 LEU A CB  1 
ATOM   90   C CG  . LEU A 1 202 ? -9.899  49.003  105.801 1.00 73.89  ?  183 LEU A CG  1 
ATOM   91   C CD1 . LEU A 1 202 ? -11.115 49.552  106.511 1.00 73.68  ?  183 LEU A CD1 1 
ATOM   92   C CD2 . LEU A 1 202 ? -8.635  49.389  106.498 1.00 70.25  ?  183 LEU A CD2 1 
ATOM   93   N N   . PRO A 1 203 ? -8.011  44.821  105.555 1.00 79.94  ?  184 PRO A N   1 
ATOM   94   C CA  . PRO A 1 203 ? -8.028  43.412  105.988 1.00 76.76  ?  184 PRO A CA  1 
ATOM   95   C C   . PRO A 1 203 ? -9.012  43.230  107.131 1.00 82.89  ?  184 PRO A C   1 
ATOM   96   O O   . PRO A 1 203 ? -8.975  43.975  108.115 1.00 81.08  ?  184 PRO A O   1 
ATOM   97   C CB  . PRO A 1 203 ? -6.586  43.159  106.446 1.00 76.08  ?  184 PRO A CB  1 
ATOM   98   C CG  . PRO A 1 203 ? -6.100  44.500  106.883 1.00 80.03  ?  184 PRO A CG  1 
ATOM   99   C CD  . PRO A 1 203 ? -6.796  45.528  105.995 1.00 73.49  ?  184 PRO A CD  1 
ATOM   100  N N   . HIS A 1 204 ? -9.898  42.233  107.004 1.00 88.17  ?  185 HIS A N   1 
ATOM   101  C CA  . HIS A 1 204 ? -10.876 42.034  108.068 1.00 87.33  ?  185 HIS A CA  1 
ATOM   102  C C   . HIS A 1 204 ? -10.278 41.506  109.361 1.00 84.46  ?  185 HIS A C   1 
ATOM   103  O O   . HIS A 1 204 ? -10.898 41.680  110.409 1.00 90.14  ?  185 HIS A O   1 
ATOM   104  C CB  . HIS A 1 204 ? -11.993 41.080  107.679 1.00 87.79  ?  185 HIS A CB  1 
ATOM   105  C CG  . HIS A 1 204 ? -11.508 39.732  107.249 1.00 102.00 ?  185 HIS A CG  1 
ATOM   106  N ND1 . HIS A 1 204 ? -10.981 38.809  108.132 1.00 99.79  ?  185 HIS A ND1 1 
ATOM   107  C CD2 . HIS A 1 204 ? -11.601 39.100  106.055 1.00 102.64 ?  185 HIS A CD2 1 
ATOM   108  C CE1 . HIS A 1 204 ? -10.657 37.714  107.470 1.00 97.41  ?  185 HIS A CE1 1 
ATOM   109  N NE2 . HIS A 1 204 ? -11.042 37.856  106.214 1.00 105.73 ?  185 HIS A NE2 1 
ATOM   110  N N   . ASP A 1 205 ? -9.108  40.875  109.332 1.00 85.57  ?  186 ASP A N   1 
ATOM   111  C CA  . ASP A 1 205 ? -8.653  40.067  110.460 1.00 89.22  ?  186 ASP A CA  1 
ATOM   112  C C   . ASP A 1 205 ? -7.418  40.610  111.161 1.00 88.04  ?  186 ASP A C   1 
ATOM   113  O O   . ASP A 1 205 ? -6.868  39.936  112.044 1.00 85.59  ?  186 ASP A O   1 
ATOM   114  C CB  . ASP A 1 205 ? -8.381  38.623  110.027 1.00 93.27  ?  186 ASP A CB  1 
ATOM   115  C CG  . ASP A 1 205 ? -7.317  38.499  108.928 1.00 99.26  ?  186 ASP A CG  1 
ATOM   116  O OD1 . ASP A 1 205 ? -7.236  37.399  108.345 1.00 105.47 ?  186 ASP A OD1 1 
ATOM   117  O OD2 . ASP A 1 205 ? -6.580  39.472  108.618 1.00 101.74 ?  186 ASP A OD2 1 
ATOM   118  N N   . ARG A 1 206 ? -6.929  41.776  110.766 1.00 87.01  ?  187 ARG A N   1 
ATOM   119  C CA  . ARG A 1 206 ? -5.891  42.411  111.556 1.00 92.76  ?  187 ARG A CA  1 
ATOM   120  C C   . ARG A 1 206 ? -6.079  43.910  111.406 1.00 90.18  ?  187 ARG A C   1 
ATOM   121  O O   . ARG A 1 206 ? -6.807  44.383  110.526 1.00 86.68  ?  187 ARG A O   1 
ATOM   122  C CB  . ARG A 1 206 ? -4.486  41.928  111.153 1.00 89.27  ?  187 ARG A CB  1 
ATOM   123  C CG  . ARG A 1 206 ? -4.086  42.244  109.757 1.00 89.40  ?  187 ARG A CG  1 
ATOM   124  C CD  . ARG A 1 206 ? -2.569  42.285  109.575 1.00 97.11  ?  187 ARG A CD  1 
ATOM   125  N NE  . ARG A 1 206 ? -2.229  42.912  108.296 1.00 111.24 ?  187 ARG A NE  1 
ATOM   126  C CZ  . ARG A 1 206 ? -2.623  42.479  107.096 1.00 104.44 ?  187 ARG A CZ  1 
ATOM   127  N NH1 . ARG A 1 206 ? -3.362  41.383  106.962 1.00 101.93 ?  187 ARG A NH1 1 
ATOM   128  N NH2 . ARG A 1 206 ? -2.260  43.156  106.013 1.00 104.94 ?  187 ARG A NH2 1 
ATOM   129  N N   . MET A 1 207 ? -5.486  44.647  112.326 1.00 87.14  ?  188 MET A N   1 
ATOM   130  C CA  . MET A 1 207 ? -5.586  46.089  112.297 1.00 82.56  ?  188 MET A CA  1 
ATOM   131  C C   . MET A 1 207 ? -4.434  46.681  111.503 1.00 80.75  ?  188 MET A C   1 
ATOM   132  O O   . MET A 1 207 ? -3.309  46.158  111.516 1.00 77.11  ?  188 MET A O   1 
ATOM   133  C CB  . MET A 1 207 ? -5.634  46.632  113.722 1.00 83.04  ?  188 MET A CB  1 
ATOM   134  C CG  . MET A 1 207 ? -6.680  45.956  114.616 1.00 85.17  ?  188 MET A CG  1 
ATOM   135  S SD  . MET A 1 207 ? -6.779  46.556  116.352 1.00 95.53  ?  188 MET A SD  1 
ATOM   136  C CE  . MET A 1 207 ? -7.254  48.296  116.183 1.00 81.91  ?  188 MET A CE  1 
ATOM   137  N N   . THR A 1 208 ? -4.742  47.781  110.797 1.00 77.88  ?  189 THR A N   1 
ATOM   138  C CA  . THR A 1 208 ? -3.821  48.479  109.905 1.00 72.21  ?  189 THR A CA  1 
ATOM   139  C C   . THR A 1 208 ? -2.808  49.288  110.699 1.00 72.55  ?  189 THR A C   1 
ATOM   140  O O   . THR A 1 208 ? -2.921  49.460  111.909 1.00 80.28  ?  189 THR A O   1 
ATOM   141  C CB  . THR A 1 208 ? -4.579  49.405  108.941 1.00 80.64  ?  189 THR A CB  1 
ATOM   142  O OG1 . THR A 1 208 ? -5.040  50.599  109.614 1.00 79.74  ?  189 THR A OG1 1 
ATOM   143  C CG2 . THR A 1 208 ? -5.750  48.688  108.293 1.00 73.46  ?  189 THR A CG2 1 
ATOM   144  N N   . SER A 1 209 ? -1.815  49.818  110.001 1.00 76.49  ?  190 SER A N   1 
ATOM   145  C CA  . SER A 1 209 ? -0.882  50.725  110.657 1.00 75.70  ?  190 SER A CA  1 
ATOM   146  C C   . SER A 1 209 ? -1.598  51.968  111.172 1.00 78.80  ?  190 SER A C   1 
ATOM   147  O O   . SER A 1 209 ? -1.268  52.499  112.245 1.00 69.07  ?  190 SER A O   1 
ATOM   148  C CB  . SER A 1 209 ? 0.223   51.121  109.689 1.00 72.76  ?  190 SER A CB  1 
ATOM   149  O OG  . SER A 1 209 ? 1.357   51.543  110.409 1.00 72.39  ?  190 SER A OG  1 
ATOM   150  N N   . GLN A 1 210 ? -2.586  52.447  110.421 1.00 79.17  ?  191 GLN A N   1 
ATOM   151  C CA  . GLN A 1 210 ? -3.288  53.636  110.871 1.00 75.56  ?  191 GLN A CA  1 
ATOM   152  C C   . GLN A 1 210 ? -4.040  53.379  112.157 1.00 77.81  ?  191 GLN A C   1 
ATOM   153  O O   . GLN A 1 210 ? -4.065  54.226  113.053 1.00 81.74  ?  191 GLN A O   1 
ATOM   154  C CB  . GLN A 1 210 ? -4.248  54.127  109.811 1.00 79.89  ?  191 GLN A CB  1 
ATOM   155  C CG  . GLN A 1 210 ? -4.754  55.458  110.190 1.00 89.69  ?  191 GLN A CG  1 
ATOM   156  C CD  . GLN A 1 210 ? -5.415  56.166  109.058 1.00 95.45  ?  191 GLN A CD  1 
ATOM   157  O OE1 . GLN A 1 210 ? -5.941  55.536  108.132 1.00 93.13  ?  191 GLN A OE1 1 
ATOM   158  N NE2 . GLN A 1 210 ? -5.394  57.502  109.113 1.00 94.47  ?  191 GLN A NE2 1 
ATOM   159  N N   . GLU A 1 211 ? -4.663  52.220  112.267 1.00 79.12  ?  192 GLU A N   1 
ATOM   160  C CA  . GLU A 1 211 ? -5.435  51.934  113.463 1.00 76.77  ?  192 GLU A CA  1 
ATOM   161  C C   . GLU A 1 211 ? -4.525  51.706  114.661 1.00 73.54  ?  192 GLU A C   1 
ATOM   162  O O   . GLU A 1 211 ? -4.861  52.103  115.777 1.00 73.12  ?  192 GLU A O   1 
ATOM   163  C CB  . GLU A 1 211 ? -6.349  50.749  113.169 1.00 78.96  ?  192 GLU A CB  1 
ATOM   164  C CG  . GLU A 1 211 ? -7.185  51.079  111.939 1.00 84.94  ?  192 GLU A CG  1 
ATOM   165  C CD  . GLU A 1 211 ? -8.060  49.962  111.406 1.00 84.70  ?  192 GLU A CD  1 
ATOM   166  O OE1 . GLU A 1 211 ? -7.625  48.767  111.415 1.00 80.26  ?  192 GLU A OE1 1 
ATOM   167  O OE2 . GLU A 1 211 ? -9.184  50.330  110.957 1.00 78.38  ?  192 GLU A OE2 1 
ATOM   168  N N   . ALA A 1 212 ? -3.354  51.119  114.442 1.00 74.56  ?  193 ALA A N   1 
ATOM   169  C CA  . ALA A 1 212 ? -2.382  51.022  115.519 1.00 73.03  ?  193 ALA A CA  1 
ATOM   170  C C   . ALA A 1 212 ? -2.050  52.389  116.084 1.00 72.99  ?  193 ALA A C   1 
ATOM   171  O O   . ALA A 1 212 ? -1.760  52.522  117.276 1.00 74.53  ?  193 ALA A O   1 
ATOM   172  C CB  . ALA A 1 212 ? -1.113  50.340  115.018 1.00 75.87  ?  193 ALA A CB  1 
ATOM   173  N N   . ALA A 1 213 ? -2.087  53.416  115.252 1.00 78.13  ?  194 ALA A N   1 
ATOM   174  C CA  . ALA A 1 213 ? -1.716  54.737  115.725 1.00 74.97  ?  194 ALA A CA  1 
ATOM   175  C C   . ALA A 1 213 ? -2.861  55.419  116.465 1.00 74.93  ?  194 ALA A C   1 
ATOM   176  O O   . ALA A 1 213 ? -2.618  56.179  117.406 1.00 76.71  ?  194 ALA A O   1 
ATOM   177  C CB  . ALA A 1 213 ? -1.241  55.577  114.546 1.00 67.78  ?  194 ALA A CB  1 
ATOM   178  N N   . CYS A 1 214 ? -4.099  55.167  116.065 1.00 73.67  ?  195 CYS A N   1 
ATOM   179  C CA  . CYS A 1 214 ? -5.238  55.747  116.753 1.00 78.41  ?  195 CYS A CA  1 
ATOM   180  C C   . CYS A 1 214 ? -5.710  54.914  117.933 1.00 79.64  ?  195 CYS A C   1 
ATOM   181  O O   . CYS A 1 214 ? -6.346  55.447  118.846 1.00 85.58  ?  195 CYS A O   1 
ATOM   182  C CB  . CYS A 1 214 ? -6.396  55.918  115.782 1.00 78.22  ?  195 CYS A CB  1 
ATOM   183  S SG  . CYS A 1 214 ? -6.004  56.971  114.440 1.00 95.96  ?  195 CYS A SG  1 
ATOM   184  N N   . PHE A 1 215 ? -5.434  53.616  117.929 1.00 78.01  ?  196 PHE A N   1 
ATOM   185  C CA  . PHE A 1 215 ? -5.888  52.725  118.993 1.00 72.39  ?  196 PHE A CA  1 
ATOM   186  C C   . PHE A 1 215 ? -4.712  51.916  119.521 1.00 73.60  ?  196 PHE A C   1 
ATOM   187  O O   . PHE A 1 215 ? -4.770  50.691  119.595 1.00 71.45  ?  196 PHE A O   1 
ATOM   188  C CB  . PHE A 1 215 ? -6.992  51.804  118.491 1.00 71.03  ?  196 PHE A CB  1 
ATOM   189  C CG  . PHE A 1 215 ? -8.184  52.523  117.916 1.00 74.33  ?  196 PHE A CG  1 
ATOM   190  C CD1 . PHE A 1 215 ? -8.177  52.989  116.618 1.00 74.05  ?  196 PHE A CD1 1 
ATOM   191  C CD2 . PHE A 1 215 ? -9.328  52.708  118.668 1.00 80.90  ?  196 PHE A CD2 1 
ATOM   192  C CE1 . PHE A 1 215 ? -9.291  53.643  116.087 1.00 77.85  ?  196 PHE A CE1 1 
ATOM   193  C CE2 . PHE A 1 215 ? -10.451 53.367  118.138 1.00 78.68  ?  196 PHE A CE2 1 
ATOM   194  C CZ  . PHE A 1 215 ? -10.428 53.831  116.856 1.00 76.05  ?  196 PHE A CZ  1 
ATOM   195  N N   . PRO A 1 216 ? -3.619  52.576  119.906 1.00 75.42  ?  197 PRO A N   1 
ATOM   196  C CA  . PRO A 1 216 ? -2.464  51.816  120.406 1.00 73.17  ?  197 PRO A CA  1 
ATOM   197  C C   . PRO A 1 216 ? -2.770  51.046  121.656 1.00 79.49  ?  197 PRO A C   1 
ATOM   198  O O   . PRO A 1 216 ? -2.012  50.129  121.995 1.00 84.69  ?  197 PRO A O   1 
ATOM   199  C CB  . PRO A 1 216 ? -1.407  52.895  120.665 1.00 75.39  ?  197 PRO A CB  1 
ATOM   200  C CG  . PRO A 1 216 ? -2.204  54.122  120.932 1.00 75.55  ?  197 PRO A CG  1 
ATOM   201  C CD  . PRO A 1 216 ? -3.452  54.027  120.107 1.00 73.59  ?  197 PRO A CD  1 
ATOM   202  N N   . ASP A 1 217 ? -3.852  51.384  122.365 1.00 80.53  ?  198 ASP A N   1 
ATOM   203  C CA  . ASP A 1 217 ? -4.245  50.576  123.517 1.00 80.89  ?  198 ASP A CA  1 
ATOM   204  C C   . ASP A 1 217 ? -4.784  49.218  123.074 1.00 84.07  ?  198 ASP A C   1 
ATOM   205  O O   . ASP A 1 217 ? -4.433  48.186  123.661 1.00 91.64  ?  198 ASP A O   1 
ATOM   206  C CB  . ASP A 1 217 ? -5.271  51.321  124.372 1.00 78.25  ?  198 ASP A CB  1 
ATOM   207  C CG  . ASP A 1 217 ? -6.432  51.882  123.554 1.00 84.46  ?  198 ASP A CG  1 
ATOM   208  O OD1 . ASP A 1 217 ? -6.185  52.689  122.636 1.00 81.93  ?  198 ASP A OD1 1 
ATOM   209  O OD2 . ASP A 1 217 ? -7.597  51.517  123.830 1.00 88.59  ?  198 ASP A OD2 1 
ATOM   210  N N   . ILE A 1 218 ? -5.605  49.196  122.019 1.00 79.67  ?  199 ILE A N   1 
ATOM   211  C CA  . ILE A 1 218 ? -6.184  47.946  121.523 1.00 79.59  ?  199 ILE A CA  1 
ATOM   212  C C   . ILE A 1 218 ? -5.095  47.005  121.004 1.00 81.81  ?  199 ILE A C   1 
ATOM   213  O O   . ILE A 1 218 ? -5.059  45.818  121.342 1.00 89.07  ?  199 ILE A O   1 
ATOM   214  C CB  . ILE A 1 218 ? -7.220  48.241  120.424 1.00 78.77  ?  199 ILE A CB  1 
ATOM   215  C CG1 . ILE A 1 218 ? -8.280  49.263  120.883 1.00 73.26  ?  199 ILE A CG1 1 
ATOM   216  C CG2 . ILE A 1 218 ? -7.807  46.944  119.898 1.00 79.19  ?  199 ILE A CG2 1 
ATOM   217  C CD1 . ILE A 1 218 ? -9.001  48.941  122.147 1.00 75.81  ?  199 ILE A CD1 1 
ATOM   218  N N   . ILE A 1 219 ? -4.196  47.528  120.173 1.00 87.67  ?  200 ILE A N   1 
ATOM   219  C CA  . ILE A 1 219 ? -3.216  46.726  119.442 1.00 85.27  ?  200 ILE A CA  1 
ATOM   220  C C   . ILE A 1 219 ? -2.184  46.086  120.362 1.00 83.79  ?  200 ILE A C   1 
ATOM   221  O O   . ILE A 1 219 ? -1.803  44.930  120.158 1.00 91.89  ?  200 ILE A O   1 
ATOM   222  C CB  . ILE A 1 219 ? -2.537  47.587  118.366 1.00 90.20  ?  200 ILE A CB  1 
ATOM   223  C CG1 . ILE A 1 219 ? -3.490  47.850  117.234 1.00 88.50  ?  200 ILE A CG1 1 
ATOM   224  C CG2 . ILE A 1 219 ? -1.531  46.800  117.717 1.00 90.31  ?  200 ILE A CG2 1 
ATOM   225  C CD1 . ILE A 1 219 ? -3.723  46.578  116.528 1.00 78.99  ?  200 ILE A CD1 1 
ATOM   226  N N   . SER A 1 220 ? -1.670  46.820  121.350 1.00 82.50  ?  201 SER A N   1 
ATOM   227  C CA  . SER A 1 220 ? -0.767  46.184  122.300 1.00 84.52  ?  201 SER A CA  1 
ATOM   228  C C   . SER A 1 220 ? -1.526  45.370  123.330 1.00 85.56  ?  201 SER A C   1 
ATOM   229  O O   . SER A 1 220 ? -0.894  44.692  124.149 1.00 86.91  ?  201 SER A O   1 
ATOM   230  C CB  . SER A 1 220 ? 0.107   47.219  123.006 1.00 81.61  ?  201 SER A CB  1 
ATOM   231  O OG  . SER A 1 220 ? -0.687  48.094  123.785 1.00 90.98  ?  201 SER A OG  1 
ATOM   232  N N   . GLY A 1 221 ? -2.865  45.416  123.266 1.00 85.53  ?  202 GLY A N   1 
ATOM   233  C CA  . GLY A 1 221 ? -3.725  44.768  124.220 1.00 91.76  ?  202 GLY A CA  1 
ATOM   234  C C   . GLY A 1 221 ? -3.921  43.299  123.926 1.00 95.66  ?  202 GLY A C   1 
ATOM   235  O O   . GLY A 1 221 ? -3.282  42.703  123.044 1.00 93.29  ?  202 GLY A O   1 
ATOM   236  N N   . PRO A 1 222 ? -4.808  42.686  124.710 1.00 99.98  ?  203 PRO A N   1 
ATOM   237  C CA  . PRO A 1 222 ? -5.090  41.255  124.544 1.00 100.96 ?  203 PRO A CA  1 
ATOM   238  C C   . PRO A 1 222 ? -5.718  40.923  123.192 1.00 100.79 ?  203 PRO A C   1 
ATOM   239  O O   . PRO A 1 222 ? -6.549  41.670  122.663 1.00 94.06  ?  203 PRO A O   1 
ATOM   240  C CB  . PRO A 1 222 ? -6.053  40.952  125.701 1.00 95.25  ?  203 PRO A CB  1 
ATOM   241  C CG  . PRO A 1 222 ? -6.550  42.273  126.177 1.00 87.62  ?  203 PRO A CG  1 
ATOM   242  C CD  . PRO A 1 222 ? -5.427  43.225  125.932 1.00 95.36  ?  203 PRO A CD  1 
ATOM   243  N N   . GLN A 1 223 ? -5.322  39.756  122.663 1.00 102.89 ?  204 GLN A N   1 
ATOM   244  C CA  . GLN A 1 223 ? -5.779  39.282  121.360 1.00 100.27 ?  204 GLN A CA  1 
ATOM   245  C C   . GLN A 1 223 ? -7.297  39.317  121.234 1.00 102.31 ?  204 GLN A C   1 
ATOM   246  O O   . GLN A 1 223 ? -7.842  39.459  120.131 1.00 97.10  ?  204 GLN A O   1 
ATOM   247  C CB  . GLN A 1 223 ? -5.259  37.862  121.137 1.00 102.90 ?  204 GLN A CB  1 
ATOM   248  C CG  . GLN A 1 223 ? -5.403  37.399  119.716 1.00 113.03 ?  204 GLN A CG  1 
ATOM   249  C CD  . GLN A 1 223 ? -4.299  37.961  118.831 1.00 117.87 ?  204 GLN A CD  1 
ATOM   250  O OE1 . GLN A 1 223 ? -4.566  38.574  117.782 1.00 107.31 ?  204 GLN A OE1 1 
ATOM   251  N NE2 . GLN A 1 223 ? -3.046  37.746  119.244 1.00 119.47 ?  204 GLN A NE2 1 
ATOM   252  N N   . GLN A 1 224 ? -7.999  39.198  122.354 1.00 105.93 ?  205 GLN A N   1 
ATOM   253  C CA  . GLN A 1 224 ? -9.451  39.213  122.293 1.00 106.71 ?  205 GLN A CA  1 
ATOM   254  C C   . GLN A 1 224 ? -9.966  40.630  122.046 1.00 98.59  ?  205 GLN A C   1 
ATOM   255  O O   . GLN A 1 224 ? -10.860 40.831  121.217 1.00 99.48  ?  205 GLN A O   1 
ATOM   256  C CB  . GLN A 1 224 ? -10.002 38.570  123.571 1.00 110.66 ?  205 GLN A CB  1 
ATOM   257  C CG  . GLN A 1 224 ? -11.510 38.382  123.665 1.00 115.48 ?  205 GLN A CG  1 
ATOM   258  C CD  . GLN A 1 224 ? -12.096 37.604  122.476 1.00 120.04 ?  205 GLN A CD  1 
ATOM   259  O OE1 . GLN A 1 224 ? -12.884 38.159  121.703 1.00 119.53 ?  205 GLN A OE1 1 
ATOM   260  N NE2 . GLN A 1 224 ? -11.643 36.361  122.271 1.00 115.68 ?  205 GLN A NE2 1 
ATOM   261  N N   . THR A 1 225 ? -9.380  41.627  122.718 1.00 97.07  ?  206 THR A N   1 
ATOM   262  C CA  . THR A 1 225 ? -9.793  43.019  122.523 1.00 95.93  ?  206 THR A CA  1 
ATOM   263  C C   . THR A 1 225 ? -9.610  43.454  121.073 1.00 94.27  ?  206 THR A C   1 
ATOM   264  O O   . THR A 1 225 ? -10.519 44.055  120.484 1.00 89.67  ?  206 THR A O   1 
ATOM   265  C CB  . THR A 1 225 ? -9.008  43.940  123.466 1.00 97.17  ?  206 THR A CB  1 
ATOM   266  O OG1 . THR A 1 225 ? -9.287  43.575  124.821 1.00 101.71 ?  206 THR A OG1 1 
ATOM   267  C CG2 . THR A 1 225 ? -9.409  45.403  123.271 1.00 80.45  ?  206 THR A CG2 1 
ATOM   268  N N   . GLN A 1 226 ? -8.424  43.176  120.489 1.00 96.81  ?  207 GLN A N   1 
ATOM   269  C CA  . GLN A 1 226 ? -8.179  43.446  119.066 1.00 88.03  ?  207 GLN A CA  1 
ATOM   270  C C   . GLN A 1 226 ? -9.318  42.919  118.211 1.00 87.78  ?  207 GLN A C   1 
ATOM   271  O O   . GLN A 1 226 ? -9.730  43.553  117.232 1.00 87.23  ?  207 GLN A O   1 
ATOM   272  C CB  . GLN A 1 226 ? -6.866  42.809  118.588 1.00 75.55  ?  207 GLN A CB  1 
ATOM   273  C CG  . GLN A 1 226 ? -5.649  43.059  119.445 1.00 82.43  ?  207 GLN A CG  1 
ATOM   274  C CD  . GLN A 1 226 ? -4.369  42.659  118.740 1.00 85.36  ?  207 GLN A CD  1 
ATOM   275  O OE1 . GLN A 1 226 ? -4.374  42.396  117.540 1.00 88.70  ?  207 GLN A OE1 1 
ATOM   276  N NE2 . GLN A 1 226 ? -3.266  42.605  119.481 1.00 81.62  ?  207 GLN A NE2 1 
ATOM   277  N N   . LYS A 1 227 ? -9.849  41.760  118.580 1.00 92.37  ?  208 LYS A N   1 
ATOM   278  C CA  . LYS A 1 227 ? -10.864 41.100  117.777 1.00 94.32  ?  208 LYS A CA  1 
ATOM   279  C C   . LYS A 1 227 ? -12.222 41.790  117.925 1.00 92.07  ?  208 LYS A C   1 
ATOM   280  O O   . LYS A 1 227 ? -13.002 41.880  116.961 1.00 88.62  ?  208 LYS A O   1 
ATOM   281  C CB  . LYS A 1 227 ? -10.906 39.634  118.191 1.00 96.23  ?  208 LYS A CB  1 
ATOM   282  C CG  . LYS A 1 227 ? -11.704 38.766  117.279 1.00 102.92 ?  208 LYS A CG  1 
ATOM   283  C CD  . LYS A 1 227 ? -11.585 37.330  117.707 1.00 102.62 ?  208 LYS A CD  1 
ATOM   284  C CE  . LYS A 1 227 ? -12.329 36.463  116.744 1.00 104.09 ?  208 LYS A CE  1 
ATOM   285  N NZ  . LYS A 1 227 ? -13.790 36.714  116.899 1.00 110.90 ?  208 LYS A NZ  1 
ATOM   286  N N   . VAL A 1 228 ? -12.511 42.296  119.122 1.00 90.51  ?  209 VAL A N   1 
ATOM   287  C CA  . VAL A 1 228 ? -13.779 42.982  119.346 1.00 94.76  ?  209 VAL A CA  1 
ATOM   288  C C   . VAL A 1 228 ? -13.835 44.230  118.483 1.00 93.45  ?  209 VAL A C   1 
ATOM   289  O O   . VAL A 1 228 ? -14.827 44.506  117.794 1.00 95.50  ?  209 VAL A O   1 
ATOM   290  C CB  . VAL A 1 228 ? -13.928 43.355  120.832 1.00 96.12  ?  209 VAL A CB  1 
ATOM   291  C CG1 . VAL A 1 228 ? -15.305 44.003  121.105 1.00 86.26  ?  209 VAL A CG1 1 
ATOM   292  C CG2 . VAL A 1 228 ? -13.558 42.185  121.758 1.00 93.16  ?  209 VAL A CG2 1 
ATOM   293  N N   . PHE A 1 229 ? -12.758 45.014  118.539 1.00 91.83  ?  210 PHE A N   1 
ATOM   294  C CA  . PHE A 1 229 ? -12.592 46.187  117.692 1.00 90.35  ?  210 PHE A CA  1 
ATOM   295  C C   . PHE A 1 229 ? -12.870 45.863  116.230 1.00 90.95  ?  210 PHE A C   1 
ATOM   296  O O   . PHE A 1 229 ? -13.628 46.576  115.552 1.00 83.44  ?  210 PHE A O   1 
ATOM   297  C CB  . PHE A 1 229 ? -11.162 46.723  117.849 1.00 81.35  ?  210 PHE A CB  1 
ATOM   298  C CG  . PHE A 1 229 ? -10.824 47.782  116.871 1.00 82.89  ?  210 PHE A CG  1 
ATOM   299  C CD1 . PHE A 1 229 ? -10.886 49.110  117.235 1.00 86.95  ?  210 PHE A CD1 1 
ATOM   300  C CD2 . PHE A 1 229 ? -10.489 47.466  115.567 1.00 85.92  ?  210 PHE A CD2 1 
ATOM   301  C CE1 . PHE A 1 229 ? -10.600 50.099  116.324 1.00 82.57  ?  210 PHE A CE1 1 
ATOM   302  C CE2 . PHE A 1 229 ? -10.224 48.448  114.650 1.00 84.97  ?  210 PHE A CE2 1 
ATOM   303  C CZ  . PHE A 1 229 ? -10.276 49.766  115.028 1.00 79.43  ?  210 PHE A CZ  1 
ATOM   304  N N   . LEU A 1 230 ? -12.202 44.818  115.713 1.00 86.05  ?  211 LEU A N   1 
ATOM   305  C CA  . LEU A 1 230 ? -12.266 44.548  114.284 1.00 83.49  ?  211 LEU A CA  1 
ATOM   306  C C   . LEU A 1 230 ? -13.701 44.303  113.856 1.00 87.66  ?  211 LEU A C   1 
ATOM   307  O O   . LEU A 1 230 ? -14.117 44.743  112.776 1.00 86.98  ?  211 LEU A O   1 
ATOM   308  C CB  . LEU A 1 230 ? -11.369 43.364  113.909 1.00 81.12  ?  211 LEU A CB  1 
ATOM   309  C CG  . LEU A 1 230 ? -9.841  43.481  114.016 1.00 82.63  ?  211 LEU A CG  1 
ATOM   310  C CD1 . LEU A 1 230 ? -9.152  42.143  114.127 1.00 83.21  ?  211 LEU A CD1 1 
ATOM   311  C CD2 . LEU A 1 230 ? -9.284  44.179  112.826 1.00 84.11  ?  211 LEU A CD2 1 
ATOM   312  N N   . PHE A 1 231 ? -14.491 43.636  114.706 1.00 89.51  ?  212 PHE A N   1 
ATOM   313  C CA  . PHE A 1 231 ? -15.894 43.436  114.361 1.00 92.05  ?  212 PHE A CA  1 
ATOM   314  C C   . PHE A 1 231 ? -16.644 44.761  114.353 1.00 88.25  ?  212 PHE A C   1 
ATOM   315  O O   . PHE A 1 231 ? -17.472 45.011  113.463 1.00 82.04  ?  212 PHE A O   1 
ATOM   316  C CB  . PHE A 1 231 ? -16.568 42.445  115.319 1.00 91.59  ?  212 PHE A CB  1 
ATOM   317  C CG  . PHE A 1 231 ? -18.031 42.226  115.004 1.00 96.76  ?  212 PHE A CG  1 
ATOM   318  C CD1 . PHE A 1 231 ? -18.414 41.329  114.016 1.00 96.07  ?  212 PHE A CD1 1 
ATOM   319  C CD2 . PHE A 1 231 ? -19.022 42.961  115.654 1.00 98.72  ?  212 PHE A CD2 1 
ATOM   320  C CE1 . PHE A 1 231 ? -19.756 41.146  113.697 1.00 94.17  ?  212 PHE A CE1 1 
ATOM   321  C CE2 . PHE A 1 231 ? -20.368 42.788  115.340 1.00 100.62 ?  212 PHE A CE2 1 
ATOM   322  C CZ  . PHE A 1 231 ? -20.732 41.874  114.358 1.00 100.41 ?  212 PHE A CZ  1 
ATOM   323  N N   . ILE A 1 232 ? -16.367 45.612  115.348 1.00 88.37  ?  213 ILE A N   1 
ATOM   324  C CA  . ILE A 1 232 ? -17.034 46.905  115.441 1.00 89.96  ?  213 ILE A CA  1 
ATOM   325  C C   . ILE A 1 232 ? -16.717 47.748  114.214 1.00 84.99  ?  213 ILE A C   1 
ATOM   326  O O   . ILE A 1 232 ? -17.615 48.322  113.588 1.00 81.06  ?  213 ILE A O   1 
ATOM   327  C CB  . ILE A 1 232 ? -16.636 47.611  116.748 1.00 90.33  ?  213 ILE A CB  1 
ATOM   328  C CG1 . ILE A 1 232 ? -16.988 46.719  117.942 1.00 88.32  ?  213 ILE A CG1 1 
ATOM   329  C CG2 . ILE A 1 232 ? -17.293 48.991  116.841 1.00 85.52  ?  213 ILE A CG2 1 
ATOM   330  C CD1 . ILE A 1 232 ? -16.427 47.206  119.252 1.00 89.47  ?  213 ILE A CD1 1 
ATOM   331  N N   . ARG A 1 233 ? -15.437 47.807  113.834 1.00 83.19  ?  214 ARG A N   1 
ATOM   332  C CA  . ARG A 1 233 ? -15.062 48.494  112.602 1.00 83.13  ?  214 ARG A CA  1 
ATOM   333  C C   . ARG A 1 233 ? -15.839 47.936  111.417 1.00 88.34  ?  214 ARG A C   1 
ATOM   334  O O   . ARG A 1 233 ? -16.541 48.680  110.713 1.00 83.34  ?  214 ARG A O   1 
ATOM   335  C CB  . ARG A 1 233 ? -13.551 48.382  112.355 1.00 82.01  ?  214 ARG A CB  1 
ATOM   336  C CG  . ARG A 1 233 ? -13.208 48.294  110.867 1.00 80.57  ?  214 ARG A CG  1 
ATOM   337  C CD  . ARG A 1 233 ? -11.840 48.789  110.447 1.00 83.64  ?  214 ARG A CD  1 
ATOM   338  N NE  . ARG A 1 233 ? -10.671 47.939  110.720 1.00 76.50  ?  214 ARG A NE  1 
ATOM   339  C CZ  . ARG A 1 233 ? -10.385 46.805  110.083 1.00 80.16  ?  214 ARG A CZ  1 
ATOM   340  N NH1 . ARG A 1 233 ? -11.226 46.314  109.187 1.00 85.74  ?  214 ARG A NH1 1 
ATOM   341  N NH2 . ARG A 1 233 ? -9.275  46.132  110.365 1.00 80.76  ?  214 ARG A NH2 1 
ATOM   342  N N   . ASN A 1 234 ? -15.736 46.604  111.201 1.00 92.27  ?  215 ASN A N   1 
ATOM   343  C CA  . ASN A 1 234 ? -16.270 45.968  109.997 1.00 80.06  ?  215 ASN A CA  1 
ATOM   344  C C   . ASN A 1 234 ? -17.777 46.103  109.934 1.00 84.13  ?  215 ASN A C   1 
ATOM   345  O O   . ASN A 1 234 ? -18.342 46.296  108.853 1.00 84.57  ?  215 ASN A O   1 
ATOM   346  C CB  . ASN A 1 234 ? -15.853 44.500  109.954 1.00 82.99  ?  215 ASN A CB  1 
ATOM   347  C CG  . ASN A 1 234 ? -14.346 44.323  109.833 1.00 88.23  ?  215 ASN A CG  1 
ATOM   348  O OD1 . ASN A 1 234 ? -13.641 45.274  109.505 1.00 88.14  ?  215 ASN A OD1 1 
ATOM   349  N ND2 . ASN A 1 234 ? -13.847 43.096  110.060 1.00 80.64  ?  215 ASN A ND2 1 
ATOM   350  N N   . ARG A 1 235 ? -18.434 46.064  111.094 1.00 89.85  ?  216 ARG A N   1 
ATOM   351  C CA  . ARG A 1 235 ? -19.883 46.208  111.134 1.00 92.07  ?  216 ARG A CA  1 
ATOM   352  C C   . ARG A 1 235 ? -20.311 47.635  110.800 1.00 86.81  ?  216 ARG A C   1 
ATOM   353  O O   . ARG A 1 235 ? -21.303 47.842  110.084 1.00 86.35  ?  216 ARG A O   1 
ATOM   354  C CB  . ARG A 1 235 ? -20.409 45.775  112.506 1.00 93.14  ?  216 ARG A CB  1 
ATOM   355  C CG  . ARG A 1 235 ? -21.921 45.742  112.545 1.00 97.75  ?  216 ARG A CG  1 
ATOM   356  C CD  . ARG A 1 235 ? -22.445 44.701  111.554 1.00 102.71 ?  216 ARG A CD  1 
ATOM   357  N NE  . ARG A 1 235 ? -23.733 45.100  110.991 1.00 104.23 ?  216 ARG A NE  1 
ATOM   358  C CZ  . ARG A 1 235 ? -24.899 44.945  111.606 1.00 107.68 ?  216 ARG A CZ  1 
ATOM   359  N NH1 . ARG A 1 235 ? -24.950 44.369  112.810 1.00 110.03 ?  216 ARG A NH1 1 
ATOM   360  N NH2 . ARG A 1 235 ? -26.010 45.353  111.002 1.00 101.42 ?  216 ARG A NH2 1 
ATOM   361  N N   . THR A 1 236 ? -19.578 48.631  111.307 1.00 84.45  ?  217 THR A N   1 
ATOM   362  C CA  . THR A 1 236 ? -19.900 50.017  110.975 1.00 88.50  ?  217 THR A CA  1 
ATOM   363  C C   . THR A 1 236 ? -19.678 50.295  109.498 1.00 90.92  ?  217 THR A C   1 
ATOM   364  O O   . THR A 1 236 ? -20.478 50.999  108.860 1.00 90.52  ?  217 THR A O   1 
ATOM   365  C CB  . THR A 1 236 ? -19.059 50.978  111.808 1.00 90.20  ?  217 THR A CB  1 
ATOM   366  O OG1 . THR A 1 236 ? -19.227 50.680  113.199 1.00 93.23  ?  217 THR A OG1 1 
ATOM   367  C CG2 . THR A 1 236 ? -19.470 52.419  111.528 1.00 85.82  ?  217 THR A CG2 1 
ATOM   368  N N   . LEU A 1 237 ? -18.580 49.765  108.946 1.00 90.64  ?  218 LEU A N   1 
ATOM   369  C CA  . LEU A 1 237 ? -18.356 49.844  107.508 1.00 88.12  ?  218 LEU A CA  1 
ATOM   370  C C   . LEU A 1 237 ? -19.541 49.272  106.751 1.00 88.45  ?  218 LEU A C   1 
ATOM   371  O O   . LEU A 1 237 ? -20.055 49.892  105.808 1.00 84.22  ?  218 LEU A O   1 
ATOM   372  C CB  . LEU A 1 237 ? -17.072 49.104  107.152 1.00 81.57  ?  218 LEU A CB  1 
ATOM   373  C CG  . LEU A 1 237 ? -15.854 49.816  107.717 1.00 83.74  ?  218 LEU A CG  1 
ATOM   374  C CD1 . LEU A 1 237 ? -14.669 48.887  107.759 1.00 81.32  ?  218 LEU A CD1 1 
ATOM   375  C CD2 . LEU A 1 237 ? -15.564 51.075  106.890 1.00 75.01  ?  218 LEU A CD2 1 
ATOM   376  N N   . GLN A 1 238 ? -20.007 48.096  107.188 1.00 85.16  ?  219 GLN A N   1 
ATOM   377  C CA  . GLN A 1 238 ? -21.150 47.456  106.554 1.00 88.26  ?  219 GLN A CA  1 
ATOM   378  C C   . GLN A 1 238 ? -22.365 48.370  106.558 1.00 94.62  ?  219 GLN A C   1 
ATOM   379  O O   . GLN A 1 238 ? -23.010 48.574  105.521 1.00 95.21  ?  219 GLN A O   1 
ATOM   380  C CB  . GLN A 1 238 ? -21.462 46.146  107.265 1.00 93.40  ?  219 GLN A CB  1 
ATOM   381  C CG  . GLN A 1 238 ? -22.561 45.330  106.602 1.00 98.59  ?  219 GLN A CG  1 
ATOM   382  C CD  . GLN A 1 238 ? -22.656 43.926  107.169 1.00 105.88 ?  219 GLN A CD  1 
ATOM   383  O OE1 . GLN A 1 238 ? -22.481 43.715  108.377 1.00 104.67 ?  219 GLN A OE1 1 
ATOM   384  N NE2 . GLN A 1 238 ? -22.909 42.950  106.295 1.00 105.94 ?  219 GLN A NE2 1 
ATOM   385  N N   . LEU A 1 239 ? -22.687 48.942  107.719 1.00 91.50  ?  220 LEU A N   1 
ATOM   386  C CA  . LEU A 1 239 ? -23.857 49.804  107.791 1.00 92.93  ?  220 LEU A CA  1 
ATOM   387  C C   . LEU A 1 239 ? -23.746 50.976  106.826 1.00 91.79  ?  220 LEU A C   1 
ATOM   388  O O   . LEU A 1 239 ? -24.715 51.298  106.127 1.00 94.13  ?  220 LEU A O   1 
ATOM   389  C CB  . LEU A 1 239 ? -24.059 50.278  109.222 1.00 95.36  ?  220 LEU A CB  1 
ATOM   390  C CG  . LEU A 1 239 ? -24.793 49.188  109.996 1.00 96.20  ?  220 LEU A CG  1 
ATOM   391  C CD1 . LEU A 1 239 ? -24.820 49.536  111.452 1.00 99.26  ?  220 LEU A CD1 1 
ATOM   392  C CD2 . LEU A 1 239 ? -26.204 49.018  109.454 1.00 98.49  ?  220 LEU A CD2 1 
ATOM   393  N N   . TRP A 1 240 ? -22.564 51.605  106.744 1.00 88.72  ?  221 TRP A N   1 
ATOM   394  C CA  . TRP A 1 240 ? -22.385 52.697  105.788 1.00 93.36  ?  221 TRP A CA  1 
ATOM   395  C C   . TRP A 1 240 ? -22.540 52.197  104.354 1.00 95.31  ?  221 TRP A C   1 
ATOM   396  O O   . TRP A 1 240 ? -23.257 52.802  103.543 1.00 93.57  ?  221 TRP A O   1 
ATOM   397  C CB  . TRP A 1 240 ? -21.019 53.376  105.982 1.00 88.33  ?  221 TRP A CB  1 
ATOM   398  C CG  . TRP A 1 240 ? -20.565 54.227  104.781 1.00 86.73  ?  221 TRP A CG  1 
ATOM   399  C CD1 . TRP A 1 240 ? -19.493 53.990  103.966 1.00 85.34  ?  221 TRP A CD1 1 
ATOM   400  C CD2 . TRP A 1 240 ? -21.181 55.425  104.279 1.00 87.42  ?  221 TRP A CD2 1 
ATOM   401  N NE1 . TRP A 1 240 ? -19.404 54.959  102.994 1.00 80.09  ?  221 TRP A NE1 1 
ATOM   402  C CE2 . TRP A 1 240 ? -20.430 55.846  103.160 1.00 82.49  ?  221 TRP A CE2 1 
ATOM   403  C CE3 . TRP A 1 240 ? -22.290 56.176  104.665 1.00 86.00  ?  221 TRP A CE3 1 
ATOM   404  C CZ2 . TRP A 1 240 ? -20.752 56.978  102.429 1.00 85.14  ?  221 TRP A CZ2 1 
ATOM   405  C CZ3 . TRP A 1 240 ? -22.610 57.293  103.935 1.00 90.13  ?  221 TRP A CZ3 1 
ATOM   406  C CH2 . TRP A 1 240 ? -21.845 57.687  102.828 1.00 88.76  ?  221 TRP A CH2 1 
ATOM   407  N N   . LEU A 1 241 ? -21.888 51.075  104.029 1.00 91.59  ?  222 LEU A N   1 
ATOM   408  C CA  . LEU A 1 241 ? -21.875 50.610  102.646 1.00 91.44  ?  222 LEU A CA  1 
ATOM   409  C C   . LEU A 1 241 ? -23.251 50.156  102.179 1.00 98.94  ?  222 LEU A C   1 
ATOM   410  O O   . LEU A 1 241 ? -23.600 50.344  101.003 1.00 97.49  ?  222 LEU A O   1 
ATOM   411  C CB  . LEU A 1 241 ? -20.858 49.484  102.490 1.00 83.24  ?  222 LEU A CB  1 
ATOM   412  C CG  . LEU A 1 241 ? -19.434 50.021  102.510 1.00 83.15  ?  222 LEU A CG  1 
ATOM   413  C CD1 . LEU A 1 241 ? -18.368 48.925  102.501 1.00 73.81  ?  222 LEU A CD1 1 
ATOM   414  C CD2 . LEU A 1 241 ? -19.258 50.998  101.351 1.00 79.97  ?  222 LEU A CD2 1 
ATOM   415  N N   . ASP A 1 242 ? -24.048 49.570  103.078 1.00 102.33 ?  223 ASP A N   1 
ATOM   416  C CA  . ASP A 1 242 ? -25.375 49.101  102.695 1.00 108.79 ?  223 ASP A CA  1 
ATOM   417  C C   . ASP A 1 242 ? -26.341 50.240  102.421 1.00 109.13 ?  223 ASP A C   1 
ATOM   418  O O   . ASP A 1 242 ? -27.440 49.992  101.912 1.00 114.68 ?  223 ASP A O   1 
ATOM   419  C CB  . ASP A 1 242 ? -25.941 48.174  103.771 1.00 109.73 ?  223 ASP A CB  1 
ATOM   420  C CG  . ASP A 1 242 ? -25.267 46.804  103.771 1.00 118.00 ?  223 ASP A CG  1 
ATOM   421  O OD1 . ASP A 1 242 ? -25.013 46.265  102.664 1.00 117.84 ?  223 ASP A OD1 1 
ATOM   422  O OD2 . ASP A 1 242 ? -24.996 46.266  104.871 1.00 115.43 ?  223 ASP A OD2 1 
ATOM   423  N N   . ASN A 1 243 ? -25.950 51.466  102.719 1.00 103.41 ?  224 ASN A N   1 
ATOM   424  C CA  . ASN A 1 243 ? -26.773 52.621  102.434 1.00 103.25 ?  224 ASN A CA  1 
ATOM   425  C C   . ASN A 1 243 ? -25.908 53.870  102.533 1.00 103.51 ?  224 ASN A C   1 
ATOM   426  O O   . ASN A 1 243 ? -25.720 54.413  103.629 1.00 102.00 ?  224 ASN A O   1 
ATOM   427  C CB  . ASN A 1 243 ? -27.952 52.684  103.400 1.00 105.02 ?  224 ASN A CB  1 
ATOM   428  C CG  . ASN A 1 243 ? -28.891 53.819  103.083 1.00 111.73 ?  224 ASN A CG  1 
ATOM   429  O OD1 . ASN A 1 243 ? -28.786 54.458  102.020 1.00 108.94 ?  224 ASN A OD1 1 
ATOM   430  N ND2 . ASN A 1 243 ? -29.827 54.078  103.996 1.00 108.02 ?  224 ASN A ND2 1 
ATOM   431  N N   . PRO A 1 244 ? -25.352 54.341  101.426 1.00 101.08 ?  225 PRO A N   1 
ATOM   432  C CA  . PRO A 1 244 ? -24.444 55.482  101.498 1.00 95.07  ?  225 PRO A CA  1 
ATOM   433  C C   . PRO A 1 244 ? -25.096 56.753  100.994 1.00 97.77  ?  225 PRO A C   1 
ATOM   434  O O   . PRO A 1 244 ? -24.407 57.701  100.604 1.00 98.28  ?  225 PRO A O   1 
ATOM   435  C CB  . PRO A 1 244 ? -23.289 55.050  100.591 1.00 92.46  ?  225 PRO A CB  1 
ATOM   436  C CG  . PRO A 1 244 ? -23.862 53.918  99.730  1.00 93.40  ?  225 PRO A CG  1 
ATOM   437  C CD  . PRO A 1 244 ? -25.304 53.732  100.095 1.00 98.02  ?  225 PRO A CD  1 
ATOM   438  N N   . LYS A 1 245 ? -26.425 56.785  100.975 1.00 99.67  ?  226 LYS A N   1 
ATOM   439  C CA  . LYS A 1 245 ? -27.141 57.992  100.588 1.00 99.96  ?  226 LYS A CA  1 
ATOM   440  C C   . LYS A 1 245 ? -27.593 58.817  101.794 1.00 99.83  ?  226 LYS A C   1 
ATOM   441  O O   . LYS A 1 245 ? -28.096 59.932  101.613 1.00 97.70  ?  226 LYS A O   1 
ATOM   442  C CB  . LYS A 1 245 ? -28.340 57.616  99.706  1.00 101.53 ?  226 LYS A CB  1 
ATOM   443  C CG  . LYS A 1 245 ? -27.945 56.935  98.393  1.00 99.98  ?  226 LYS A CG  1 
ATOM   444  C CD  . LYS A 1 245 ? -29.157 56.400  97.651  1.00 104.61 ?  226 LYS A CD  1 
ATOM   445  C CE  . LYS A 1 245 ? -30.023 57.535  97.117  1.00 107.29 ?  226 LYS A CE  1 
ATOM   446  N NZ  . LYS A 1 245 ? -29.338 58.317  96.055  1.00 102.05 ?  226 LYS A NZ  1 
ATOM   447  N N   . ILE A 1 246 ? -27.408 58.292  103.013 1.00 98.81  ?  227 ILE A N   1 
ATOM   448  C CA  . ILE A 1 246 ? -27.692 58.961  104.278 1.00 100.80 ?  227 ILE A CA  1 
ATOM   449  C C   . ILE A 1 246 ? -26.443 58.931  105.144 1.00 100.35 ?  227 ILE A C   1 
ATOM   450  O O   . ILE A 1 246 ? -25.629 58.004  105.066 1.00 98.15  ?  227 ILE A O   1 
ATOM   451  C CB  . ILE A 1 246 ? -28.846 58.293  105.068 1.00 104.28 ?  227 ILE A CB  1 
ATOM   452  C CG1 . ILE A 1 246 ? -28.457 56.836  105.387 1.00 105.81 ?  227 ILE A CG1 1 
ATOM   453  C CG2 . ILE A 1 246 ? -30.178 58.420  104.344 1.00 100.36 ?  227 ILE A CG2 1 
ATOM   454  C CD1 . ILE A 1 246 ? -29.348 56.105  106.364 1.00 107.31 ?  227 ILE A CD1 1 
ATOM   455  N N   . GLN A 1 247 ? -26.321 59.930  106.013 1.00 99.60  ?  228 GLN A N   1 
ATOM   456  C CA  . GLN A 1 247 ? -25.290 59.893  107.037 1.00 95.15  ?  228 GLN A CA  1 
ATOM   457  C C   . GLN A 1 247 ? -25.490 58.695  107.964 1.00 94.26  ?  228 GLN A C   1 
ATOM   458  O O   . GLN A 1 247 ? -26.614 58.284  108.260 1.00 96.12  ?  228 GLN A O   1 
ATOM   459  C CB  . GLN A 1 247 ? -25.305 61.194  107.836 1.00 99.28  ?  228 GLN A CB  1 
ATOM   460  C CG  . GLN A 1 247 ? -24.255 61.254  108.937 1.00 103.48 ?  228 GLN A CG  1 
ATOM   461  C CD  . GLN A 1 247 ? -24.113 62.634  109.554 1.00 102.81 ?  228 GLN A CD  1 
ATOM   462  O OE1 . GLN A 1 247 ? -24.927 63.530  109.314 1.00 105.83 ?  228 GLN A OE1 1 
ATOM   463  N NE2 . GLN A 1 247 ? -23.072 62.808  110.363 1.00 98.63  ?  228 GLN A NE2 1 
ATOM   464  N N   . LEU A 1 248 ? -24.384 58.131  108.422 1.00 91.46  ?  229 LEU A N   1 
ATOM   465  C CA  . LEU A 1 248 ? -24.398 57.065  109.418 1.00 91.93  ?  229 LEU A CA  1 
ATOM   466  C C   . LEU A 1 248 ? -23.947 57.663  110.748 1.00 95.33  ?  229 LEU A C   1 
ATOM   467  O O   . LEU A 1 248 ? -22.747 57.835  110.986 1.00 90.89  ?  229 LEU A O   1 
ATOM   468  C CB  . LEU A 1 248 ? -23.500 55.913  108.998 1.00 88.30  ?  229 LEU A CB  1 
ATOM   469  C CG  . LEU A 1 248 ? -23.386 54.815  110.050 1.00 88.60  ?  229 LEU A CG  1 
ATOM   470  C CD1 . LEU A 1 248 ? -24.734 54.158  110.264 1.00 90.82  ?  229 LEU A CD1 1 
ATOM   471  C CD2 . LEU A 1 248 ? -22.346 53.794  109.675 1.00 87.75  ?  229 LEU A CD2 1 
ATOM   472  N N   . THR A 1 249 ? -24.912 57.961  111.617 1.00 102.22 ?  230 THR A N   1 
ATOM   473  C CA  . THR A 1 249 ? -24.639 58.615  112.892 1.00 102.69 ?  230 THR A CA  1 
ATOM   474  C C   . THR A 1 249 ? -24.086 57.612  113.896 1.00 101.47 ?  230 THR A C   1 
ATOM   475  O O   . THR A 1 249 ? -24.298 56.400  113.786 1.00 100.71 ?  230 THR A O   1 
ATOM   476  C CB  . THR A 1 249 ? -25.905 59.206  113.493 1.00 104.01 ?  230 THR A CB  1 
ATOM   477  O OG1 . THR A 1 249 ? -26.760 58.136  113.909 1.00 103.90 ?  230 THR A OG1 1 
ATOM   478  C CG2 . THR A 1 249 ? -26.635 60.037  112.442 1.00 102.72 ?  230 THR A CG2 1 
ATOM   479  N N   . PHE A 1 250 ? -23.405 58.137  114.916 1.00 101.29 ?  231 PHE A N   1 
ATOM   480  C CA  . PHE A 1 250 ? -22.892 57.255  115.958 1.00 100.16 ?  231 PHE A CA  1 
ATOM   481  C C   . PHE A 1 250 ? -24.032 56.542  116.666 1.00 103.84 ?  231 PHE A C   1 
ATOM   482  O O   . PHE A 1 250 ? -23.957 55.336  116.933 1.00 99.69  ?  231 PHE A O   1 
ATOM   483  C CB  . PHE A 1 250 ? -22.044 58.047  116.954 1.00 98.12  ?  231 PHE A CB  1 
ATOM   484  C CG  . PHE A 1 250 ? -21.809 57.329  118.259 1.00 100.65 ?  231 PHE A CG  1 
ATOM   485  C CD1 . PHE A 1 250 ? -21.343 56.013  118.284 1.00 99.22  ?  231 PHE A CD1 1 
ATOM   486  C CD2 . PHE A 1 250 ? -22.045 57.973  119.465 1.00 100.35 ?  231 PHE A CD2 1 
ATOM   487  C CE1 . PHE A 1 250 ? -21.137 55.351  119.493 1.00 98.20  ?  231 PHE A CE1 1 
ATOM   488  C CE2 . PHE A 1 250 ? -21.829 57.320  120.669 1.00 98.23  ?  231 PHE A CE2 1 
ATOM   489  C CZ  . PHE A 1 250 ? -21.377 56.007  120.685 1.00 96.23  ?  231 PHE A CZ  1 
ATOM   490  N N   . GLU A 1 251 ? -25.098 57.279  116.976 1.00 111.25 ?  232 GLU A N   1 
ATOM   491  C CA  . GLU A 1 251 ? -26.259 56.694  117.632 1.00 109.66 ?  232 GLU A CA  1 
ATOM   492  C C   . GLU A 1 251 ? -26.829 55.572  116.786 1.00 109.27 ?  232 GLU A C   1 
ATOM   493  O O   . GLU A 1 251 ? -26.928 54.425  117.240 1.00 111.76 ?  232 GLU A O   1 
ATOM   494  C CB  . GLU A 1 251 ? -27.310 57.775  117.882 1.00 111.95 ?  232 GLU A CB  1 
ATOM   495  C CG  . GLU A 1 251 ? -26.874 58.818  118.902 1.00 114.90 ?  232 GLU A CG  1 
ATOM   496  C CD  . GLU A 1 251 ? -26.215 60.044  118.257 1.00 122.59 ?  232 GLU A CD  1 
ATOM   497  O OE1 . GLU A 1 251 ? -26.314 60.199  117.012 1.00 119.21 ?  232 GLU A OE1 1 
ATOM   498  O OE2 . GLU A 1 251 ? -25.604 60.854  119.000 1.00 122.62 ?  232 GLU A OE2 1 
ATOM   499  N N   . ALA A 1 252 ? -27.180 55.891  115.531 1.00 108.64 ?  233 ALA A N   1 
ATOM   500  C CA  . ALA A 1 252 ? -27.682 54.884  114.599 1.00 108.29 ?  233 ALA A CA  1 
ATOM   501  C C   . ALA A 1 252 ? -26.755 53.682  114.518 1.00 104.91 ?  233 ALA A C   1 
ATOM   502  O O   . ALA A 1 252 ? -27.220 52.546  114.370 1.00 106.18 ?  233 ALA A O   1 
ATOM   503  C CB  . ALA A 1 252 ? -27.880 55.494  113.206 1.00 106.41 ?  233 ALA A CB  1 
ATOM   504  N N   . THR A 1 253 ? -25.444 53.905  114.634 1.00 104.01 ?  234 THR A N   1 
ATOM   505  C CA  . THR A 1 253 ? -24.505 52.788  114.597 1.00 102.89 ?  234 THR A CA  1 
ATOM   506  C C   . THR A 1 253 ? -24.714 51.853  115.780 1.00 103.85 ?  234 THR A C   1 
ATOM   507  O O   . THR A 1 253 ? -24.839 50.634  115.608 1.00 103.73 ?  234 THR A O   1 
ATOM   508  C CB  . THR A 1 253 ? -23.066 53.304  114.571 1.00 96.82  ?  234 THR A CB  1 
ATOM   509  O OG1 . THR A 1 253 ? -22.792 53.908  113.301 1.00 91.94  ?  234 THR A OG1 1 
ATOM   510  C CG2 . THR A 1 253 ? -22.088 52.169  114.818 1.00 90.01  ?  234 THR A CG2 1 
ATOM   511  N N   . LEU A 1 254 ? -24.768 52.409  116.991 1.00 107.80 ?  235 LEU A N   1 
ATOM   512  C CA  . LEU A 1 254 ? -24.795 51.583  118.188 1.00 106.58 ?  235 LEU A CA  1 
ATOM   513  C C   . LEU A 1 254 ? -26.143 50.919  118.419 1.00 110.02 ?  235 LEU A C   1 
ATOM   514  O O   . LEU A 1 254 ? -26.191 49.889  119.108 1.00 109.69 ?  235 LEU A O   1 
ATOM   515  C CB  . LEU A 1 254 ? -24.358 52.413  119.394 1.00 102.79 ?  235 LEU A CB  1 
ATOM   516  C CG  . LEU A 1 254 ? -24.304 51.754  120.764 1.00 100.57 ?  235 LEU A CG  1 
ATOM   517  C CD1 . LEU A 1 254 ? -23.488 50.509  120.696 1.00 108.49 ?  235 LEU A CD1 1 
ATOM   518  C CD2 . LEU A 1 254 ? -23.590 52.729  121.658 1.00 96.09  ?  235 LEU A CD2 1 
ATOM   519  N N   . GLN A 1 255 ? -27.229 51.441  117.833 1.00 108.36 ?  236 GLN A N   1 
ATOM   520  C CA  . GLN A 1 255 ? -28.493 50.712  117.895 1.00 110.23 ?  236 GLN A CA  1 
ATOM   521  C C   . GLN A 1 255 ? -28.371 49.358  117.206 1.00 115.21 ?  236 GLN A C   1 
ATOM   522  O O   . GLN A 1 255 ? -28.713 48.319  117.787 1.00 119.70 ?  236 GLN A O   1 
ATOM   523  C CB  . GLN A 1 255 ? -29.633 51.534  117.285 1.00 110.02 ?  236 GLN A CB  1 
ATOM   524  C CG  . GLN A 1 255 ? -29.807 52.937  117.869 1.00 118.74 ?  236 GLN A CG  1 
ATOM   525  C CD  . GLN A 1 255 ? -29.883 52.973  119.407 1.00 128.91 ?  236 GLN A CD  1 
ATOM   526  O OE1 . GLN A 1 255 ? -29.584 54.009  120.019 1.00 126.23 ?  236 GLN A OE1 1 
ATOM   527  N NE2 . GLN A 1 255 ? -30.319 51.862  120.030 1.00 126.42 ?  236 GLN A NE2 1 
ATOM   528  N N   . GLN A 1 256 ? -27.848 49.349  115.974 1.00 114.10 ?  237 GLN A N   1 
ATOM   529  C CA  . GLN A 1 256 ? -27.783 48.132  115.174 1.00 110.72 ?  237 GLN A CA  1 
ATOM   530  C C   . GLN A 1 256 ? -26.675 47.179  115.602 1.00 108.49 ?  237 GLN A C   1 
ATOM   531  O O   . GLN A 1 256 ? -26.604 46.066  115.075 1.00 110.33 ?  237 GLN A O   1 
ATOM   532  C CB  . GLN A 1 256 ? -27.644 48.501  113.698 1.00 102.88 ?  237 GLN A CB  1 
ATOM   533  C CG  . GLN A 1 256 ? -28.978 48.533  112.987 1.00 107.23 ?  237 GLN A CG  1 
ATOM   534  C CD  . GLN A 1 256 ? -28.977 49.420  111.760 1.00 119.79 ?  237 GLN A CD  1 
ATOM   535  O OE1 . GLN A 1 256 ? -28.250 50.415  111.700 1.00 115.93 ?  237 GLN A OE1 1 
ATOM   536  N NE2 . GLN A 1 256 ? -29.784 49.054  110.760 1.00 120.35 ?  237 GLN A NE2 1 
ATOM   537  N N   . LEU A 1 257 ? -25.825 47.570  116.542 1.00 108.14 ?  238 LEU A N   1 
ATOM   538  C CA  . LEU A 1 257 ? -24.925 46.614  117.167 1.00 113.29 ?  238 LEU A CA  1 
ATOM   539  C C   . LEU A 1 257 ? -25.649 45.819  118.248 1.00 119.23 ?  238 LEU A C   1 
ATOM   540  O O   . LEU A 1 257 ? -26.577 46.311  118.907 1.00 119.14 ?  238 LEU A O   1 
ATOM   541  C CB  . LEU A 1 257 ? -23.724 47.320  117.788 1.00 114.78 ?  238 LEU A CB  1 
ATOM   542  C CG  . LEU A 1 257 ? -22.514 47.601  116.914 1.00 109.52 ?  238 LEU A CG  1 
ATOM   543  C CD1 . LEU A 1 257 ? -21.695 48.723  117.524 1.00 108.53 ?  238 LEU A CD1 1 
ATOM   544  C CD2 . LEU A 1 257 ? -21.693 46.339  116.809 1.00 111.78 ?  238 LEU A CD2 1 
ATOM   545  N N   . GLU A 1 258 ? -25.202 44.581  118.435 1.00 120.59 ?  239 GLU A N   1 
ATOM   546  C CA  . GLU A 1 258 ? -25.704 43.718  119.490 1.00 119.98 ?  239 GLU A CA  1 
ATOM   547  C C   . GLU A 1 258 ? -24.566 43.369  120.439 1.00 116.45 ?  239 GLU A C   1 
ATOM   548  O O   . GLU A 1 258 ? -23.388 43.415  120.071 1.00 116.61 ?  239 GLU A O   1 
ATOM   549  C CB  . GLU A 1 258 ? -26.334 42.445  118.912 1.00 122.19 ?  239 GLU A CB  1 
ATOM   550  C CG  . GLU A 1 258 ? -27.535 42.720  118.010 1.00 129.35 ?  239 GLU A CG  1 
ATOM   551  C CD  . GLU A 1 258 ? -28.436 41.504  117.835 1.00 143.30 ?  239 GLU A CD  1 
ATOM   552  O OE1 . GLU A 1 258 ? -27.990 40.372  118.145 1.00 141.52 ?  239 GLU A OE1 1 
ATOM   553  O OE2 . GLU A 1 258 ? -29.593 41.684  117.386 1.00 143.03 ?  239 GLU A OE2 1 
ATOM   554  N N   . ALA A 1 259 ? -24.935 43.037  121.679 1.00 114.20 ?  240 ALA A N   1 
ATOM   555  C CA  . ALA A 1 259 ? -23.957 42.651  122.683 1.00 112.92 ?  240 ALA A CA  1 
ATOM   556  C C   . ALA A 1 259 ? -23.218 41.385  122.243 1.00 111.58 ?  240 ALA A C   1 
ATOM   557  O O   . ALA A 1 259 ? -23.737 40.597  121.450 1.00 111.14 ?  240 ALA A O   1 
ATOM   558  C CB  . ALA A 1 259 ? -24.647 42.435  124.029 1.00 112.46 ?  240 ALA A CB  1 
ATOM   559  N N   . PRO A 1 260 ? -21.987 41.166  122.738 1.00 110.98 ?  241 PRO A N   1 
ATOM   560  C CA  . PRO A 1 260 ? -21.231 41.960  123.719 1.00 110.08 ?  241 PRO A CA  1 
ATOM   561  C C   . PRO A 1 260 ? -20.614 43.232  123.134 1.00 114.22 ?  241 PRO A C   1 
ATOM   562  O O   . PRO A 1 260 ? -20.005 44.015  123.864 1.00 112.45 ?  241 PRO A O   1 
ATOM   563  C CB  . PRO A 1 260 ? -20.136 40.995  124.164 1.00 108.82 ?  241 PRO A CB  1 
ATOM   564  C CG  . PRO A 1 260 ? -19.883 40.146  122.944 1.00 109.36 ?  241 PRO A CG  1 
ATOM   565  C CD  . PRO A 1 260 ? -21.197 40.032  122.215 1.00 105.07 ?  241 PRO A CD  1 
ATOM   566  N N   . TYR A 1 261 ? -20.784 43.425  121.821 1.00 116.41 ?  242 TYR A N   1 
ATOM   567  C CA  . TYR A 1 261 ? -20.119 44.512  121.111 1.00 112.19 ?  242 TYR A CA  1 
ATOM   568  C C   . TYR A 1 261 ? -20.730 45.871  121.409 1.00 114.93 ?  242 TYR A C   1 
ATOM   569  O O   . TYR A 1 261 ? -20.002 46.870  121.447 1.00 113.58 ?  242 TYR A O   1 
ATOM   570  C CB  . TYR A 1 261 ? -20.152 44.253  119.607 1.00 108.38 ?  242 TYR A CB  1 
ATOM   571  C CG  . TYR A 1 261 ? -19.633 42.892  119.241 1.00 107.70 ?  242 TYR A CG  1 
ATOM   572  C CD1 . TYR A 1 261 ? -18.329 42.526  119.554 1.00 107.68 ?  242 TYR A CD1 1 
ATOM   573  C CD2 . TYR A 1 261 ? -20.444 41.966  118.593 1.00 109.01 ?  242 TYR A CD2 1 
ATOM   574  C CE1 . TYR A 1 261 ? -17.835 41.272  119.225 1.00 110.01 ?  242 TYR A CE1 1 
ATOM   575  C CE2 . TYR A 1 261 ? -19.962 40.704  118.252 1.00 110.03 ?  242 TYR A CE2 1 
ATOM   576  C CZ  . TYR A 1 261 ? -18.652 40.359  118.573 1.00 111.84 ?  242 TYR A CZ  1 
ATOM   577  O OH  . TYR A 1 261 ? -18.150 39.108  118.243 1.00 106.14 ?  242 TYR A OH  1 
ATOM   578  N N   . ASN A 1 262 ? -22.052 45.942  121.607 1.00 116.63 ?  243 ASN A N   1 
ATOM   579  C CA  . ASN A 1 262 ? -22.699 47.206  121.940 1.00 113.91 ?  243 ASN A CA  1 
ATOM   580  C C   . ASN A 1 262 ? -22.685 47.488  123.439 1.00 110.94 ?  243 ASN A C   1 
ATOM   581  O O   . ASN A 1 262 ? -23.523 48.250  123.933 1.00 111.09 ?  243 ASN A O   1 
ATOM   582  C CB  . ASN A 1 262 ? -24.122 47.256  121.361 1.00 112.73 ?  243 ASN A CB  1 
ATOM   583  C CG  . ASN A 1 262 ? -25.166 46.549  122.215 1.00 116.77 ?  243 ASN A CG  1 
ATOM   584  O OD1 . ASN A 1 262 ? -24.861 45.685  123.047 1.00 116.54 ?  243 ASN A OD1 1 
ATOM   585  N ND2 . ASN A 1 262 ? -26.428 46.918  121.994 1.00 116.90 ?  243 ASN A ND2 1 
ATOM   586  N N   . SER A 1 263 ? -21.732 46.905  124.171 1.00 110.55 ?  244 SER A N   1 
ATOM   587  C CA  . SER A 1 263 ? -21.586 47.135  125.606 1.00 112.42 ?  244 SER A CA  1 
ATOM   588  C C   . SER A 1 263 ? -20.652 48.311  125.892 1.00 114.19 ?  244 SER A C   1 
ATOM   589  O O   . SER A 1 263 ? -21.044 49.270  126.569 1.00 116.15 ?  244 SER A O   1 
ATOM   590  C CB  . SER A 1 263 ? -21.078 45.865  126.297 1.00 114.29 ?  244 SER A CB  1 
ATOM   591  O OG  . SER A 1 263 ? -19.756 45.565  125.890 1.00 112.71 ?  244 SER A OG  1 
ATOM   592  N N   . ASP A 1 264 ? -19.412 48.248  125.394 1.00 113.39 ?  245 ASP A N   1 
ATOM   593  C CA  . ASP A 1 264 ? -18.479 49.371  125.520 1.00 106.52 ?  245 ASP A CA  1 
ATOM   594  C C   . ASP A 1 264 ? -18.898 50.474  124.560 1.00 100.31 ?  245 ASP A C   1 
ATOM   595  O O   . ASP A 1 264 ? -18.728 50.343  123.346 1.00 104.32 ?  245 ASP A O   1 
ATOM   596  C CB  . ASP A 1 264 ? -17.045 48.934  125.228 1.00 94.65  ?  245 ASP A CB  1 
ATOM   597  C CG  . ASP A 1 264 ? -16.010 49.989  125.641 1.00 101.83 ?  245 ASP A CG  1 
ATOM   598  O OD1 . ASP A 1 264 ? -16.382 51.170  125.878 1.00 96.94  ?  245 ASP A OD1 1 
ATOM   599  O OD2 . ASP A 1 264 ? -14.813 49.630  125.724 1.00 104.12 ?  245 ASP A OD2 1 
ATOM   600  N N   . THR A 1 265 ? -19.439 51.566  125.086 1.00 96.06  ?  246 THR A N   1 
ATOM   601  C CA  . THR A 1 265 ? -19.852 52.638  124.198 1.00 98.41  ?  246 THR A CA  1 
ATOM   602  C C   . THR A 1 265 ? -18.702 53.560  123.808 1.00 99.41  ?  246 THR A C   1 
ATOM   603  O O   . THR A 1 265 ? -18.795 54.216  122.763 1.00 98.40  ?  246 THR A O   1 
ATOM   604  C CB  . THR A 1 265 ? -20.980 53.461  124.825 1.00 99.58  ?  246 THR A CB  1 
ATOM   605  O OG1 . THR A 1 265 ? -20.498 54.136  125.997 1.00 100.27 ?  246 THR A OG1 1 
ATOM   606  C CG2 . THR A 1 265 ? -22.138 52.560  125.187 1.00 99.43  ?  246 THR A CG2 1 
ATOM   607  N N   . VAL A 1 266 ? -17.619 53.637  124.594 1.00 96.15  ?  247 VAL A N   1 
ATOM   608  C CA  . VAL A 1 266 ? -16.538 54.531  124.184 1.00 95.57  ?  247 VAL A CA  1 
ATOM   609  C C   . VAL A 1 266 ? -15.811 53.937  122.983 1.00 98.17  ?  247 VAL A C   1 
ATOM   610  O O   . VAL A 1 266 ? -15.509 54.643  122.009 1.00 97.11  ?  247 VAL A O   1 
ATOM   611  C CB  . VAL A 1 266 ? -15.561 54.831  125.340 1.00 89.25  ?  247 VAL A CB  1 
ATOM   612  C CG1 . VAL A 1 266 ? -16.320 55.358  126.527 1.00 95.74  ?  247 VAL A CG1 1 
ATOM   613  C CG2 . VAL A 1 266 ? -14.632 53.656  125.687 1.00 96.39  ?  247 VAL A CG2 1 
ATOM   614  N N   . LEU A 1 267 ? -15.558 52.621  123.014 1.00 94.62  ?  248 LEU A N   1 
ATOM   615  C CA  . LEU A 1 267 ? -14.926 51.954  121.881 1.00 92.40  ?  248 LEU A CA  1 
ATOM   616  C C   . LEU A 1 267 ? -15.736 52.147  120.607 1.00 89.70  ?  248 LEU A C   1 
ATOM   617  O O   . LEU A 1 267 ? -15.176 52.471  119.558 1.00 90.20  ?  248 LEU A O   1 
ATOM   618  C CB  . LEU A 1 267 ? -14.742 50.475  122.186 1.00 91.79  ?  248 LEU A CB  1 
ATOM   619  C CG  . LEU A 1 267 ? -13.865 49.763  121.177 1.00 91.63  ?  248 LEU A CG  1 
ATOM   620  C CD1 . LEU A 1 267 ? -12.485 50.390  121.199 1.00 87.77  ?  248 LEU A CD1 1 
ATOM   621  C CD2 . LEU A 1 267 ? -13.785 48.302  121.547 1.00 85.07  ?  248 LEU A CD2 1 
ATOM   622  N N   . VAL A 1 268 ? -17.058 51.989  120.678 1.00 88.52  ?  249 VAL A N   1 
ATOM   623  C CA  . VAL A 1 268 ? -17.866 52.247  119.492 1.00 88.59  ?  249 VAL A CA  1 
ATOM   624  C C   . VAL A 1 268 ? -17.776 53.710  119.085 1.00 86.31  ?  249 VAL A C   1 
ATOM   625  O O   . VAL A 1 268 ? -17.625 54.021  117.901 1.00 90.05  ?  249 VAL A O   1 
ATOM   626  C CB  . VAL A 1 268 ? -19.318 51.784  119.704 1.00 91.84  ?  249 VAL A CB  1 
ATOM   627  C CG1 . VAL A 1 268 ? -20.185 52.232  118.558 1.00 90.97  ?  249 VAL A CG1 1 
ATOM   628  C CG2 . VAL A 1 268 ? -19.356 50.261  119.764 1.00 94.45  ?  249 VAL A CG2 1 
ATOM   629  N N   . HIS A 1 269 ? -17.832 54.636  120.045 1.00 94.25  ?  250 HIS A N   1 
ATOM   630  C CA  . HIS A 1 269 ? -17.714 56.047  119.666 1.00 92.53  ?  250 HIS A CA  1 
ATOM   631  C C   . HIS A 1 269 ? -16.331 56.351  119.102 1.00 90.60  ?  250 HIS A C   1 
ATOM   632  O O   . HIS A 1 269 ? -16.201 57.152  118.169 1.00 86.37  ?  250 HIS A O   1 
ATOM   633  C CB  . HIS A 1 269 ? -18.017 56.970  120.845 1.00 86.58  ?  250 HIS A CB  1 
ATOM   634  C CG  . HIS A 1 269 ? -17.961 58.430  120.496 1.00 93.35  ?  250 HIS A CG  1 
ATOM   635  N ND1 . HIS A 1 269 ? -19.015 59.096  119.904 1.00 94.09  ?  250 HIS A ND1 1 
ATOM   636  C CD2 . HIS A 1 269 ? -16.976 59.352  120.656 1.00 87.55  ?  250 HIS A CD2 1 
ATOM   637  C CE1 . HIS A 1 269 ? -18.686 60.364  119.716 1.00 89.07  ?  250 HIS A CE1 1 
ATOM   638  N NE2 . HIS A 1 269 ? -17.454 60.544  120.162 1.00 91.40  ?  250 HIS A NE2 1 
ATOM   639  N N   . ARG A 1 270 ? -15.287 55.710  119.642 1.00 88.67  ?  251 ARG A N   1 
ATOM   640  C CA  . ARG A 1 270 ? -13.947 55.891  119.092 1.00 87.97  ?  251 ARG A CA  1 
ATOM   641  C C   . ARG A 1 270 ? -13.868 55.377  117.659 1.00 87.39  ?  251 ARG A C   1 
ATOM   642  O O   . ARG A 1 270 ? -13.387 56.079  116.759 1.00 87.06  ?  251 ARG A O   1 
ATOM   643  C CB  . ARG A 1 270 ? -12.918 55.184  119.967 1.00 83.96  ?  251 ARG A CB  1 
ATOM   644  C CG  . ARG A 1 270 ? -12.579 55.916  121.212 1.00 76.45  ?  251 ARG A CG  1 
ATOM   645  C CD  . ARG A 1 270 ? -11.718 55.057  122.059 1.00 77.15  ?  251 ARG A CD  1 
ATOM   646  N NE  . ARG A 1 270 ? -10.322 55.182  121.686 1.00 81.93  ?  251 ARG A NE  1 
ATOM   647  C CZ  . ARG A 1 270 ? -9.385  54.282  121.974 1.00 87.05  ?  251 ARG A CZ  1 
ATOM   648  N NH1 . ARG A 1 270 ? -9.690  53.165  122.632 1.00 82.11  ?  251 ARG A NH1 1 
ATOM   649  N NH2 . ARG A 1 270 ? -8.134  54.502  121.600 1.00 89.26  ?  251 ARG A NH2 1 
ATOM   650  N N   . VAL A 1 271 ? -14.348 54.150  117.434 1.00 83.60  ?  252 VAL A N   1 
ATOM   651  C CA  . VAL A 1 271 ? -14.295 53.540  116.111 1.00 77.07  ?  252 VAL A CA  1 
ATOM   652  C C   . VAL A 1 271 ? -15.099 54.352  115.109 1.00 80.88  ?  252 VAL A C   1 
ATOM   653  O O   . VAL A 1 271 ? -14.651 54.585  113.982 1.00 84.70  ?  252 VAL A O   1 
ATOM   654  C CB  . VAL A 1 271 ? -14.777 52.080  116.179 1.00 76.79  ?  252 VAL A CB  1 
ATOM   655  C CG1 . VAL A 1 271 ? -15.042 51.524  114.793 1.00 80.56  ?  252 VAL A CG1 1 
ATOM   656  C CG2 . VAL A 1 271 ? -13.742 51.231  116.876 1.00 77.64  ?  252 VAL A CG2 1 
ATOM   657  N N   . HIS A 1 272 ? -16.289 54.805  115.491 1.00 80.34  ?  253 HIS A N   1 
ATOM   658  C CA  . HIS A 1 272 ? -17.071 55.594  114.550 1.00 79.15  ?  253 HIS A CA  1 
ATOM   659  C C   . HIS A 1 272 ? -16.359 56.892  114.211 1.00 84.38  ?  253 HIS A C   1 
ATOM   660  O O   . HIS A 1 272 ? -16.343 57.325  113.053 1.00 86.05  ?  253 HIS A O   1 
ATOM   661  C CB  . HIS A 1 272 ? -18.453 55.884  115.118 1.00 81.71  ?  253 HIS A CB  1 
ATOM   662  C CG  . HIS A 1 272 ? -19.332 56.668  114.194 1.00 82.75  ?  253 HIS A CG  1 
ATOM   663  N ND1 . HIS A 1 272 ? -19.143 58.013  113.946 1.00 90.82  ?  253 HIS A ND1 1 
ATOM   664  C CD2 . HIS A 1 272 ? -20.413 56.300  113.464 1.00 86.81  ?  253 HIS A CD2 1 
ATOM   665  C CE1 . HIS A 1 272 ? -20.066 58.438  113.098 1.00 93.40  ?  253 HIS A CE1 1 
ATOM   666  N NE2 . HIS A 1 272 ? -20.849 57.417  112.789 1.00 91.61  ?  253 HIS A NE2 1 
ATOM   667  N N   . SER A 1 273 ? -15.759 57.531  115.206 1.00 85.11  ?  254 SER A N   1 
ATOM   668  C CA  . SER A 1 273 ? -15.170 58.831  114.932 1.00 87.90  ?  254 SER A CA  1 
ATOM   669  C C   . SER A 1 273 ? -13.903 58.691  114.096 1.00 86.39  ?  254 SER A C   1 
ATOM   670  O O   . SER A 1 273 ? -13.605 59.571  113.278 1.00 84.99  ?  254 SER A O   1 
ATOM   671  C CB  . SER A 1 273 ? -14.916 59.565  116.250 1.00 87.64  ?  254 SER A CB  1 
ATOM   672  O OG  . SER A 1 273 ? -16.147 59.764  116.931 1.00 79.09  ?  254 SER A OG  1 
ATOM   673  N N   . TYR A 1 274 ? -13.164 57.587  114.273 1.00 81.88  ?  255 TYR A N   1 
ATOM   674  C CA  . TYR A 1 274 ? -12.017 57.296  113.412 1.00 82.74  ?  255 TYR A CA  1 
ATOM   675  C C   . TYR A 1 274 ? -12.457 57.075  111.965 1.00 78.51  ?  255 TYR A C   1 
ATOM   676  O O   . TYR A 1 274 ? -11.847 57.598  111.025 1.00 76.06  ?  255 TYR A O   1 
ATOM   677  C CB  . TYR A 1 274 ? -11.256 56.077  113.956 1.00 83.25  ?  255 TYR A CB  1 
ATOM   678  C CG  . TYR A 1 274 ? -10.466 55.312  112.916 1.00 84.53  ?  255 TYR A CG  1 
ATOM   679  C CD1 . TYR A 1 274 ? -9.167  55.681  112.570 1.00 84.54  ?  255 TYR A CD1 1 
ATOM   680  C CD2 . TYR A 1 274 ? -11.036 54.224  112.258 1.00 84.63  ?  255 TYR A CD2 1 
ATOM   681  C CE1 . TYR A 1 274 ? -8.448  54.968  111.595 1.00 83.76  ?  255 TYR A CE1 1 
ATOM   682  C CE2 . TYR A 1 274 ? -10.342 53.521  111.295 1.00 87.64  ?  255 TYR A CE2 1 
ATOM   683  C CZ  . TYR A 1 274 ? -9.046  53.897  110.953 1.00 91.19  ?  255 TYR A CZ  1 
ATOM   684  O OH  . TYR A 1 274 ? -8.362  53.170  109.973 1.00 100.36 ?  255 TYR A OH  1 
ATOM   685  N N   . LEU A 1 275 ? -13.523 56.309  111.768 1.00 76.48  ?  256 LEU A N   1 
ATOM   686  C CA  . LEU A 1 275 ? -13.999 56.064  110.419 1.00 75.36  ?  256 LEU A CA  1 
ATOM   687  C C   . LEU A 1 275 ? -14.533 57.339  109.793 1.00 77.34  ?  256 LEU A C   1 
ATOM   688  O O   . LEU A 1 275 ? -14.350 57.574  108.595 1.00 76.67  ?  256 LEU A O   1 
ATOM   689  C CB  . LEU A 1 275 ? -15.087 54.994  110.438 1.00 76.16  ?  256 LEU A CB  1 
ATOM   690  C CG  . LEU A 1 275 ? -14.655 53.615  110.938 1.00 76.86  ?  256 LEU A CG  1 
ATOM   691  C CD1 . LEU A 1 275 ? -15.875 52.739  111.021 1.00 84.84  ?  256 LEU A CD1 1 
ATOM   692  C CD2 . LEU A 1 275 ? -13.589 52.946  110.092 1.00 73.69  ?  256 LEU A CD2 1 
ATOM   693  N N   . GLU A 1 276 ? -15.226 58.160  110.576 1.00 80.37  ?  257 GLU A N   1 
ATOM   694  C CA  . GLU A 1 276 ? -15.801 59.371  110.007 1.00 82.11  ?  257 GLU A CA  1 
ATOM   695  C C   . GLU A 1 276 ? -14.698 60.325  109.582 1.00 76.16  ?  257 GLU A C   1 
ATOM   696  O O   . GLU A 1 276 ? -14.769 60.946  108.509 1.00 74.66  ?  257 GLU A O   1 
ATOM   697  C CB  . GLU A 1 276 ? -16.741 60.022  111.025 1.00 86.97  ?  257 GLU A CB  1 
ATOM   698  C CG  . GLU A 1 276 ? -17.828 60.924  110.427 1.00 94.46  ?  257 GLU A CG  1 
ATOM   699  C CD  . GLU A 1 276 ? -18.793 61.475  111.481 1.00 98.19  ?  257 GLU A CD  1 
ATOM   700  O OE1 . GLU A 1 276 ? -18.406 61.532  112.670 1.00 98.66  ?  257 GLU A OE1 1 
ATOM   701  O OE2 . GLU A 1 276 ? -19.934 61.853  111.117 1.00 102.57 ?  257 GLU A OE2 1 
ATOM   702  N N   . ARG A 1 277 ? -13.645 60.396  110.396 1.00 72.68  ?  258 ARG A N   1 
ATOM   703  C CA  . ARG A 1 277 ? -12.588 61.373  110.198 1.00 74.21  ?  258 ARG A CA  1 
ATOM   704  C C   . ARG A 1 277 ? -11.784 61.057  108.951 1.00 79.30  ?  258 ARG A C   1 
ATOM   705  O O   . ARG A 1 277 ? -11.426 61.960  108.180 1.00 75.72  ?  258 ARG A O   1 
ATOM   706  C CB  . ARG A 1 277 ? -11.688 61.395  111.433 1.00 76.94  ?  258 ARG A CB  1 
ATOM   707  C CG  . ARG A 1 277 ? -10.665 62.508  111.457 1.00 78.11  ?  258 ARG A CG  1 
ATOM   708  C CD  . ARG A 1 277 ? -11.311 63.854  111.080 1.00 81.18  ?  258 ARG A CD  1 
ATOM   709  N NE  . ARG A 1 277 ? -11.985 64.559  112.176 1.00 78.04  ?  258 ARG A NE  1 
ATOM   710  C CZ  . ARG A 1 277 ? -11.342 65.120  113.197 1.00 75.89  ?  258 ARG A CZ  1 
ATOM   711  N NH1 . ARG A 1 277 ? -10.019 65.035  113.286 1.00 77.49  ?  258 ARG A NH1 1 
ATOM   712  N NH2 . ARG A 1 277 ? -12.020 65.757  114.136 1.00 78.95  ?  258 ARG A NH2 1 
ATOM   713  N N   . HIS A 1 278 ? -11.517 59.774  108.719 1.00 77.31  ?  259 HIS A N   1 
ATOM   714  C CA  . HIS A 1 278 ? -10.621 59.372  107.654 1.00 75.07  ?  259 HIS A CA  1 
ATOM   715  C C   . HIS A 1 278 ? -11.352 58.899  106.416 1.00 74.43  ?  259 HIS A C   1 
ATOM   716  O O   . HIS A 1 278 ? -10.762 58.201  105.589 1.00 76.60  ?  259 HIS A O   1 
ATOM   717  C CB  . HIS A 1 278 ? -9.666  58.324  108.180 1.00 76.18  ?  259 HIS A CB  1 
ATOM   718  C CG  . HIS A 1 278 ? -8.778  58.855  109.247 1.00 75.90  ?  259 HIS A CG  1 
ATOM   719  N ND1 . HIS A 1 278 ? -8.649  58.257  110.480 1.00 81.53  ?  259 HIS A ND1 1 
ATOM   720  C CD2 . HIS A 1 278 ? -7.998  59.959  109.277 1.00 82.76  ?  259 HIS A CD2 1 
ATOM   721  C CE1 . HIS A 1 278 ? -7.797  58.949  111.214 1.00 89.02  ?  259 HIS A CE1 1 
ATOM   722  N NE2 . HIS A 1 278 ? -7.391  59.992  110.509 1.00 89.98  ?  259 HIS A NE2 1 
ATOM   723  N N   . GLY A 1 279 ? -12.604 59.310  106.251 1.00 76.69  ?  260 GLY A N   1 
ATOM   724  C CA  . GLY A 1 279 ? -13.296 59.139  104.990 1.00 73.08  ?  260 GLY A CA  1 
ATOM   725  C C   . GLY A 1 279 ? -13.622 57.714  104.638 1.00 73.93  ?  260 GLY A C   1 
ATOM   726  O O   . GLY A 1 279 ? -13.752 57.396  103.453 1.00 83.48  ?  260 GLY A O   1 
ATOM   727  N N   . LEU A 1 280 ? -13.721 56.829  105.628 1.00 73.08  ?  261 LEU A N   1 
ATOM   728  C CA  . LEU A 1 280 ? -14.190 55.479  105.355 1.00 74.97  ?  261 LEU A CA  1 
ATOM   729  C C   . LEU A 1 280 ? -15.704 55.366  105.433 1.00 78.00  ?  261 LEU A C   1 
ATOM   730  O O   . LEU A 1 280 ? -16.278 54.479  104.800 1.00 76.39  ?  261 LEU A O   1 
ATOM   731  C CB  . LEU A 1 280 ? -13.524 54.480  106.301 1.00 67.61  ?  261 LEU A CB  1 
ATOM   732  C CG  . LEU A 1 280 ? -12.075 54.209  105.890 1.00 70.00  ?  261 LEU A CG  1 
ATOM   733  C CD1 . LEU A 1 280 ? -11.317 53.398  106.918 1.00 70.81  ?  261 LEU A CD1 1 
ATOM   734  C CD2 . LEU A 1 280 ? -12.038 53.506  104.540 1.00 73.12  ?  261 LEU A CD2 1 
ATOM   735  N N   . ILE A 1 281 ? -16.363 56.263  106.165 1.00 81.21  ?  262 ILE A N   1 
ATOM   736  C CA  . ILE A 1 281 ? -17.813 56.378  106.149 1.00 81.87  ?  262 ILE A CA  1 
ATOM   737  C C   . ILE A 1 281 ? -18.137 57.852  106.001 1.00 81.79  ?  262 ILE A C   1 
ATOM   738  O O   . ILE A 1 281 ? -17.290 58.714  106.234 1.00 85.31  ?  262 ILE A O   1 
ATOM   739  C CB  . ILE A 1 281 ? -18.460 55.806  107.420 1.00 83.38  ?  262 ILE A CB  1 
ATOM   740  C CG1 . ILE A 1 281 ? -18.059 56.650  108.628 1.00 84.76  ?  262 ILE A CG1 1 
ATOM   741  C CG2 . ILE A 1 281 ? -18.026 54.358  107.648 1.00 78.55  ?  262 ILE A CG2 1 
ATOM   742  C CD1 . ILE A 1 281 ? -18.570 56.099  109.926 1.00 82.29  ?  262 ILE A CD1 1 
ATOM   743  N N   . ASN A 1 282 ? -19.376 58.139  105.608 1.00 80.68  ?  263 ASN A N   1 
ATOM   744  C CA  . ASN A 1 282 ? -19.844 59.520  105.491 1.00 87.11  ?  263 ASN A CA  1 
ATOM   745  C C   . ASN A 1 282 ? -18.872 60.353  104.667 1.00 88.31  ?  263 ASN A C   1 
ATOM   746  O O   . ASN A 1 282 ? -18.435 61.436  105.074 1.00 91.82  ?  263 ASN A O   1 
ATOM   747  C CB  . ASN A 1 282 ? -20.045 60.167  106.860 1.00 90.21  ?  263 ASN A CB  1 
ATOM   748  C CG  . ASN A 1 282 ? -20.964 59.386  107.747 1.00 90.60  ?  263 ASN A CG  1 
ATOM   749  O OD1 . ASN A 1 282 ? -22.136 59.182  107.425 1.00 94.12  ?  263 ASN A OD1 1 
ATOM   750  N ND2 . ASN A 1 282 ? -20.445 58.951  108.889 1.00 91.08  ?  263 ASN A ND2 1 
ATOM   751  N N   . PHE A 1 283 ? -18.478 59.796  103.531 1.00 86.58  ?  264 PHE A N   1 
ATOM   752  C CA  . PHE A 1 283 ? -17.746 60.514  102.502 1.00 85.74  ?  264 PHE A CA  1 
ATOM   753  C C   . PHE A 1 283 ? -18.602 60.536  101.246 1.00 86.76  ?  264 PHE A C   1 
ATOM   754  O O   . PHE A 1 283 ? -19.403 59.627  101.004 1.00 91.66  ?  264 PHE A O   1 
ATOM   755  C CB  . PHE A 1 283 ? -16.380 59.864  102.200 1.00 77.46  ?  264 PHE A CB  1 
ATOM   756  C CG  . PHE A 1 283 ? -16.483 58.529  101.512 1.00 78.89  ?  264 PHE A CG  1 
ATOM   757  C CD1 . PHE A 1 283 ? -16.571 58.446  100.129 1.00 81.55  ?  264 PHE A CD1 1 
ATOM   758  C CD2 . PHE A 1 283 ? -16.492 57.355  102.250 1.00 81.86  ?  264 PHE A CD2 1 
ATOM   759  C CE1 . PHE A 1 283 ? -16.684 57.219  99.491  1.00 82.68  ?  264 PHE A CE1 1 
ATOM   760  C CE2 . PHE A 1 283 ? -16.584 56.111  101.629 1.00 82.08  ?  264 PHE A CE2 1 
ATOM   761  C CZ  . PHE A 1 283 ? -16.690 56.039  100.250 1.00 85.81  ?  264 PHE A CZ  1 
ATOM   762  N N   . GLY A 1 284 ? -18.428 61.565  100.441 1.00 78.31  ?  265 GLY A N   1 
ATOM   763  C CA  . GLY A 1 284 ? -19.171 61.606  99.205  1.00 82.18  ?  265 GLY A CA  1 
ATOM   764  C C   . GLY A 1 284 ? -20.345 62.556  99.251  1.00 86.42  ?  265 GLY A C   1 
ATOM   765  O O   . GLY A 1 284 ? -20.223 63.679  99.744  1.00 88.73  ?  265 GLY A O   1 
ATOM   766  N N   . ILE A 1 285 ? -21.490 62.122  98.744  1.00 86.57  ?  266 ILE A N   1 
ATOM   767  C CA  . ILE A 1 285 ? -22.664 62.973  98.647  1.00 85.29  ?  266 ILE A CA  1 
ATOM   768  C C   . ILE A 1 285 ? -23.774 62.277  99.420  1.00 90.79  ?  266 ILE A C   1 
ATOM   769  O O   . ILE A 1 285 ? -24.518 61.463  98.873  1.00 94.31  ?  266 ILE A O   1 
ATOM   770  C CB  . ILE A 1 285 ? -23.061 63.238  97.204  1.00 80.89  ?  266 ILE A CB  1 
ATOM   771  C CG1 . ILE A 1 285 ? -21.867 63.873  96.512  1.00 87.68  ?  266 ILE A CG1 1 
ATOM   772  C CG2 . ILE A 1 285 ? -24.189 64.217  97.196  1.00 80.75  ?  266 ILE A CG2 1 
ATOM   773  C CD1 . ILE A 1 285 ? -21.959 63.924  95.038  1.00 88.02  ?  266 ILE A CD1 1 
ATOM   774  N N   . TYR A 1 286 ? -23.879 62.603  100.706 1.00 96.20  ?  267 TYR A N   1 
ATOM   775  C CA  . TYR A 1 286 ? -24.809 61.989  101.636 1.00 92.64  ?  267 TYR A CA  1 
ATOM   776  C C   . TYR A 1 286 ? -25.703 63.065  102.229 1.00 100.74 ?  267 TYR A C   1 
ATOM   777  O O   . TYR A 1 286 ? -25.333 64.242  102.279 1.00 105.19 ?  267 TYR A O   1 
ATOM   778  C CB  . TYR A 1 286 ? -24.026 61.203  102.728 1.00 96.22  ?  267 TYR A CB  1 
ATOM   779  C CG  . TYR A 1 286 ? -22.875 61.949  103.405 1.00 98.96  ?  267 TYR A CG  1 
ATOM   780  C CD1 . TYR A 1 286 ? -21.655 62.102  102.760 1.00 99.56  ?  267 TYR A CD1 1 
ATOM   781  C CD2 . TYR A 1 286 ? -22.968 62.397  104.727 1.00 100.62 ?  267 TYR A CD2 1 
ATOM   782  C CE1 . TYR A 1 286 ? -20.581 62.768  103.358 1.00 104.01 ?  267 TYR A CE1 1 
ATOM   783  C CE2 . TYR A 1 286 ? -21.885 63.051  105.348 1.00 101.98 ?  267 TYR A CE2 1 
ATOM   784  C CZ  . TYR A 1 286 ? -20.692 63.236  104.655 1.00 103.45 ?  267 TYR A CZ  1 
ATOM   785  O OH  . TYR A 1 286 ? -19.592 63.870  105.228 1.00 94.37  ?  267 TYR A OH  1 
ATOM   786  N N   . LYS A 1 287 ? -26.902 62.652  102.640 1.00 103.08 ?  268 LYS A N   1 
ATOM   787  C CA  . LYS A 1 287 ? -27.855 63.523  103.319 1.00 106.81 ?  268 LYS A CA  1 
ATOM   788  C C   . LYS A 1 287 ? -27.532 63.556  104.809 1.00 107.68 ?  268 LYS A C   1 
ATOM   789  O O   . LYS A 1 287 ? -27.331 62.499  105.420 1.00 103.01 ?  268 LYS A O   1 
ATOM   790  C CB  . LYS A 1 287 ? -29.280 63.024  103.084 1.00 105.03 ?  268 LYS A CB  1 
ATOM   791  C CG  . LYS A 1 287 ? -30.379 63.919  103.648 1.00 114.36 ?  268 LYS A CG  1 
ATOM   792  C CD  . LYS A 1 287 ? -31.779 63.417  103.257 1.00 111.41 ?  268 LYS A CD  1 
ATOM   793  C CE  . LYS A 1 287 ? -32.899 64.281  103.852 1.00 112.74 ?  268 LYS A CE  1 
ATOM   794  N NZ  . LYS A 1 287 ? -32.947 65.667  103.265 1.00 117.90 ?  268 LYS A NZ  1 
ATOM   795  N N   . ARG A 1 288 ? -27.483 64.769  105.388 1.00 112.51 ?  269 ARG A N   1 
ATOM   796  C CA  . ARG A 1 288 ? -27.027 64.985  106.768 1.00 113.77 ?  269 ARG A CA  1 
ATOM   797  C C   . ARG A 1 288 ? -28.208 64.852  107.715 1.00 115.47 ?  269 ARG A C   1 
ATOM   798  O O   . ARG A 1 288 ? -29.111 65.694  107.704 1.00 119.53 ?  269 ARG A O   1 
ATOM   799  C CB  . ARG A 1 288 ? -26.378 66.359  106.956 1.00 112.94 ?  269 ARG A CB  1 
ATOM   800  C CG  . ARG A 1 288 ? -25.016 66.494  106.310 1.00 120.05 ?  269 ARG A CG  1 
ATOM   801  C CD  . ARG A 1 288 ? -25.198 66.832  104.823 1.00 130.51 ?  269 ARG A CD  1 
ATOM   802  N NE  . ARG A 1 288 ? -24.051 66.493  103.967 1.00 133.13 ?  269 ARG A NE  1 
ATOM   803  C CZ  . ARG A 1 288 ? -22.989 67.263  103.736 1.00 132.42 ?  269 ARG A CZ  1 
ATOM   804  N NH1 . ARG A 1 288 ? -22.871 68.466  104.304 1.00 124.40 ?  269 ARG A NH1 1 
ATOM   805  N NH2 . ARG A 1 288 ? -22.037 66.798  102.917 1.00 120.05 ?  269 ARG A NH2 1 
ATOM   806  N N   . ILE A 1 289 ? -28.191 63.807  108.549 1.00 118.63 ?  270 ILE A N   1 
ATOM   807  C CA  . ILE A 1 289 ? -29.138 63.731  109.661 1.00 122.37 ?  270 ILE A CA  1 
ATOM   808  C C   . ILE A 1 289 ? -28.964 64.937  110.575 1.00 126.07 ?  270 ILE A C   1 
ATOM   809  O O   . ILE A 1 289 ? -29.911 65.695  110.824 1.00 128.97 ?  270 ILE A O   1 
ATOM   810  C CB  . ILE A 1 289 ? -28.968 62.412  110.438 1.00 118.67 ?  270 ILE A CB  1 
ATOM   811  C CG1 . ILE A 1 289 ? -29.600 61.240  109.670 1.00 114.59 ?  270 ILE A CG1 1 
ATOM   812  C CG2 . ILE A 1 289 ? -29.565 62.552  111.834 1.00 118.51 ?  270 ILE A CG2 1 
ATOM   813  C CD1 . ILE A 1 289 ? -29.586 59.880  110.423 1.00 111.17 ?  270 ILE A CD1 1 
ATOM   814  N N   . LYS A 1 290 ? -27.739 65.142  111.071 1.00 125.70 ?  271 LYS A N   1 
ATOM   815  C CA  . LYS A 1 290 ? -27.409 66.316  111.868 1.00 128.07 ?  271 LYS A CA  1 
ATOM   816  C C   . LYS A 1 290 ? -26.996 67.447  110.937 1.00 131.66 ?  271 LYS A C   1 
ATOM   817  O O   . LYS A 1 290 ? -25.958 67.326  110.262 1.00 132.58 ?  271 LYS A O   1 
ATOM   818  C CB  . LYS A 1 290 ? -26.280 65.999  112.835 1.00 123.39 ?  271 LYS A CB  1 
ATOM   819  C CG  . LYS A 1 290 ? -26.290 64.568  113.330 1.00 117.25 ?  271 LYS A CG  1 
ATOM   820  C CD  . LYS A 1 290 ? -25.205 64.348  114.362 1.00 114.37 ?  271 LYS A CD  1 
ATOM   821  C CE  . LYS A 1 290 ? -25.615 63.275  115.359 1.00 114.99 ?  271 LYS A CE  1 
ATOM   822  N NZ  . LYS A 1 290 ? -24.480 62.839  116.224 1.00 114.07 ?  271 LYS A NZ  1 
ATOM   823  N N   . PRO A 1 291 ? -27.762 68.537  110.834 1.00 137.08 ?  272 PRO A N   1 
ATOM   824  C CA  . PRO A 1 291 ? -27.226 69.721  110.154 1.00 136.49 ?  272 PRO A CA  1 
ATOM   825  C C   . PRO A 1 291 ? -25.996 70.249  110.889 1.00 133.76 ?  272 PRO A C   1 
ATOM   826  O O   . PRO A 1 291 ? -25.892 70.181  112.118 1.00 128.48 ?  272 PRO A O   1 
ATOM   827  C CB  . PRO A 1 291 ? -28.401 70.709  110.173 1.00 133.06 ?  272 PRO A CB  1 
ATOM   828  C CG  . PRO A 1 291 ? -29.612 69.826  110.220 1.00 128.21 ?  272 PRO A CG  1 
ATOM   829  C CD  . PRO A 1 291 ? -29.192 68.708  111.154 1.00 133.99 ?  272 PRO A CD  1 
ATOM   830  N N   . LEU A 1 292 ? -25.063 70.736  110.116 1.00 132.92 ?  273 LEU A N   1 
ATOM   831  C CA  . LEU A 1 292 ? -23.697 71.070  110.484 1.00 131.75 ?  273 LEU A CA  1 
ATOM   832  C C   . LEU A 1 292 ? -23.613 72.405  111.229 1.00 136.43 ?  273 LEU A C   1 
ATOM   833  O O   . LEU A 1 292 ? -24.350 73.342  110.904 1.00 135.97 ?  273 LEU A O   1 
ATOM   834  C CB  . LEU A 1 292 ? -22.834 71.057  109.219 1.00 127.92 ?  273 LEU A CB  1 
ATOM   835  C CG  . LEU A 1 292 ? -23.331 71.848  107.993 1.00 136.62 ?  273 LEU A CG  1 
ATOM   836  C CD1 . LEU A 1 292 ? -22.967 73.343  107.937 1.00 133.21 ?  273 LEU A CD1 1 
ATOM   837  C CD2 . LEU A 1 292 ? -22.936 71.107  106.700 1.00 136.16 ?  273 LEU A CD2 1 
ATOM   838  N N   . PRO A 1 293 ? -22.717 72.491  112.273 1.00 138.51 ?  274 PRO A N   1 
ATOM   839  C CA  . PRO A 1 293 ? -22.609 73.689  113.118 1.00 135.26 ?  274 PRO A CA  1 
ATOM   840  C C   . PRO A 1 293 ? -22.767 75.045  112.451 1.00 135.27 ?  274 PRO A C   1 
ATOM   841  O O   . PRO A 1 293 ? -22.217 75.318  111.377 1.00 130.69 ?  274 PRO A O   1 
ATOM   842  C CB  . PRO A 1 293 ? -21.203 73.557  113.716 1.00 132.02 ?  274 PRO A CB  1 
ATOM   843  C CG  . PRO A 1 293 ? -20.811 72.073  113.527 1.00 128.48 ?  274 PRO A CG  1 
ATOM   844  C CD  . PRO A 1 293 ? -22.003 71.376  112.899 1.00 134.52 ?  274 PRO A CD  1 
ATOM   845  N N   . THR A 1 294 ? -23.516 75.910  113.143 1.00 139.71 ?  275 THR A N   1 
ATOM   846  C CA  . THR A 1 294 ? -23.736 77.276  112.686 1.00 138.75 ?  275 THR A CA  1 
ATOM   847  C C   . THR A 1 294 ? -22.421 78.005  112.428 1.00 133.65 ?  275 THR A C   1 
ATOM   848  O O   . THR A 1 294 ? -22.281 78.705  111.412 1.00 125.46 ?  275 THR A O   1 
ATOM   849  C CB  . THR A 1 294 ? -24.597 78.022  113.718 1.00 138.47 ?  275 THR A CB  1 
ATOM   850  O OG1 . THR A 1 294 ? -24.717 79.406  113.350 1.00 145.05 ?  275 THR A OG1 1 
ATOM   851  C CG2 . THR A 1 294 ? -24.034 77.875  115.147 1.00 126.84 ?  275 THR A CG2 1 
ATOM   852  N N   . LYS A 1 295 ? -21.435 77.842  113.319 1.00 131.75 ?  276 LYS A N   1 
ATOM   853  C CA  . LYS A 1 295 ? -20.168 78.534  113.142 1.00 126.13 ?  276 LYS A CA  1 
ATOM   854  C C   . LYS A 1 295 ? -19.020 77.533  113.104 1.00 117.77 ?  276 LYS A C   1 
ATOM   855  O O   . LYS A 1 295 ? -18.945 76.597  113.912 1.00 112.13 ?  276 LYS A O   1 
ATOM   856  C CB  . LYS A 1 295 ? -19.955 79.628  114.214 1.00 126.30 ?  276 LYS A CB  1 
ATOM   857  C CG  . LYS A 1 295 ? -18.695 80.505  113.995 1.00 119.65 ?  276 LYS A CG  1 
ATOM   858  C CD  . LYS A 1 295 ? -18.419 80.749  112.484 1.00 120.12 ?  276 LYS A CD  1 
ATOM   859  C CE  . LYS A 1 295 ? -19.486 81.518  111.705 1.00 125.42 ?  276 LYS A CE  1 
ATOM   860  N NZ  . LYS A 1 295 ? -19.251 81.427  110.220 1.00 115.48 ?  276 LYS A NZ  1 
ATOM   861  N N   . LYS A 1 296 ? -18.146 77.761  112.133 1.00 108.38 ?  277 LYS A N   1 
ATOM   862  C CA  . LYS A 1 296 ? -17.069 76.934  111.651 1.00 101.55 ?  277 LYS A CA  1 
ATOM   863  C C   . LYS A 1 296 ? -15.817 77.170  112.490 1.00 94.12  ?  277 LYS A C   1 
ATOM   864  O O   . LYS A 1 296 ? -15.790 78.007  113.389 1.00 98.25  ?  277 LYS A O   1 
ATOM   865  C CB  . LYS A 1 296 ? -16.847 77.257  110.177 1.00 97.24  ?  277 LYS A CB  1 
ATOM   866  C CG  . LYS A 1 296 ? -18.150 77.131  109.372 1.00 93.88  ?  277 LYS A CG  1 
ATOM   867  C CD  . LYS A 1 296 ? -18.112 77.816  108.003 1.00 93.05  ?  277 LYS A CD  1 
ATOM   868  C CE  . LYS A 1 296 ? -19.320 77.398  107.160 1.00 97.33  ?  277 LYS A CE  1 
ATOM   869  N NZ  . LYS A 1 296 ? -20.434 76.842  108.013 1.00 104.05 ?  277 LYS A NZ  1 
ATOM   870  N N   . THR A 1 297 ? -14.767 76.415  112.192 1.00 86.01  ?  278 THR A N   1 
ATOM   871  C CA  . THR A 1 297 ? -13.506 76.552  112.901 1.00 85.54  ?  278 THR A CA  1 
ATOM   872  C C   . THR A 1 297 ? -12.363 76.418  111.909 1.00 84.21  ?  278 THR A C   1 
ATOM   873  O O   . THR A 1 297 ? -12.352 75.478  111.115 1.00 88.53  ?  278 THR A O   1 
ATOM   874  C CB  . THR A 1 297 ? -13.387 75.493  113.992 1.00 86.53  ?  278 THR A CB  1 
ATOM   875  O OG1 . THR A 1 297 ? -14.609 75.445  114.732 1.00 91.01  ?  278 THR A OG1 1 
ATOM   876  C CG2 . THR A 1 297 ? -12.253 75.839  114.924 1.00 86.55  ?  278 THR A CG2 1 
ATOM   877  N N   . GLY A 1 298 ? -11.403 77.340  111.954 1.00 84.96  ?  279 GLY A N   1 
ATOM   878  C CA  . GLY A 1 298 ? -10.257 77.292  111.058 1.00 74.57  ?  279 GLY A CA  1 
ATOM   879  C C   . GLY A 1 298 ? -10.616 77.597  109.616 1.00 73.65  ?  279 GLY A C   1 
ATOM   880  O O   . GLY A 1 298 ? -11.754 77.366  109.194 1.00 71.09  ?  279 GLY A O   1 
ATOM   881  N N   . LYS A 1 299 ? -9.661  78.116  108.846 1.00 68.44  ?  280 LYS A N   1 
ATOM   882  C CA  . LYS A 1 299 ? -9.863  78.418  107.436 1.00 69.84  ?  280 LYS A CA  1 
ATOM   883  C C   . LYS A 1 299 ? -8.859  77.636  106.582 1.00 77.40  ?  280 LYS A C   1 
ATOM   884  O O   . LYS A 1 299 ? -7.652  77.660  106.862 1.00 78.60  ?  280 LYS A O   1 
ATOM   885  C CB  . LYS A 1 299 ? -9.716  79.911  107.191 1.00 68.29  ?  280 LYS A CB  1 
ATOM   886  C CG  . LYS A 1 299 ? -9.819  80.329  105.730 1.00 77.23  ?  280 LYS A CG  1 
ATOM   887  C CD  . LYS A 1 299 ? -11.214 79.987  105.176 1.00 82.36  ?  280 LYS A CD  1 
ATOM   888  C CE  . LYS A 1 299 ? -11.331 80.201  103.652 1.00 76.63  ?  280 LYS A CE  1 
ATOM   889  N NZ  . LYS A 1 299 ? -10.560 81.404  103.199 1.00 80.81  ?  280 LYS A NZ  1 
ATOM   890  N N   . VAL A 1 300 ? -9.344  76.968  105.528 1.00 67.36  ?  281 VAL A N   1 
ATOM   891  C CA  . VAL A 1 300 ? -8.490  76.170  104.658 1.00 67.88  ?  281 VAL A CA  1 
ATOM   892  C C   . VAL A 1 300 ? -8.681  76.655  103.235 1.00 66.21  ?  281 VAL A C   1 
ATOM   893  O O   . VAL A 1 300 ? -9.819  76.750  102.760 1.00 69.87  ?  281 VAL A O   1 
ATOM   894  C CB  . VAL A 1 300 ? -8.833  74.674  104.706 1.00 70.47  ?  281 VAL A CB  1 
ATOM   895  C CG1 . VAL A 1 300 ? -7.822  73.927  103.909 1.00 56.80  ?  281 VAL A CG1 1 
ATOM   896  C CG2 . VAL A 1 300 ? -8.997  74.143  106.135 1.00 72.28  ?  281 VAL A CG2 1 
ATOM   897  N N   . ILE A 1 301 ? -7.580  76.926  102.545 1.00 65.11  ?  282 ILE A N   1 
ATOM   898  C CA  . ILE A 1 301 ? -7.589  77.186  101.106 1.00 64.65  ?  282 ILE A CA  1 
ATOM   899  C C   . ILE A 1 301 ? -7.164  75.921  100.378 1.00 69.23  ?  282 ILE A C   1 
ATOM   900  O O   . ILE A 1 301 ? -6.186  75.254  100.773 1.00 63.00  ?  282 ILE A O   1 
ATOM   901  C CB  . ILE A 1 301 ? -6.661  78.355  100.725 1.00 70.84  ?  282 ILE A CB  1 
ATOM   902  C CG1 . ILE A 1 301 ? -7.310  79.704  101.075 1.00 69.20  ?  282 ILE A CG1 1 
ATOM   903  C CG2 . ILE A 1 301 ? -6.197  78.231  99.256  1.00 64.10  ?  282 ILE A CG2 1 
ATOM   904  C CD1 . ILE A 1 301 ? -8.634  79.957  100.332 1.00 70.28  ?  282 ILE A CD1 1 
ATOM   905  N N   . ILE A 1 302 ? -7.882  75.594  99.303  1.00 66.74  ?  283 ILE A N   1 
ATOM   906  C CA  . ILE A 1 302 ? -7.638  74.383  98.531  1.00 64.39  ?  283 ILE A CA  1 
ATOM   907  C C   . ILE A 1 302 ? -7.334  74.777  97.100  1.00 62.79  ?  283 ILE A C   1 
ATOM   908  O O   . ILE A 1 302 ? -8.220  75.261  96.389  1.00 67.40  ?  283 ILE A O   1 
ATOM   909  C CB  . ILE A 1 302 ? -8.826  73.424  98.581  1.00 63.99  ?  283 ILE A CB  1 
ATOM   910  C CG1 . ILE A 1 302 ? -9.041  72.938  100.004 1.00 61.01  ?  283 ILE A CG1 1 
ATOM   911  C CG2 . ILE A 1 302 ? -8.586  72.277  97.658  1.00 61.16  ?  283 ILE A CG2 1 
ATOM   912  C CD1 . ILE A 1 302 ? -10.194 71.970  100.115 1.00 68.83  ?  283 ILE A CD1 1 
ATOM   913  N N   . ILE A 1 303 ? -6.097  74.556  96.665  1.00 60.44  ?  284 ILE A N   1 
ATOM   914  C CA  . ILE A 1 303 ? -5.708  74.888  95.299  1.00 56.66  ?  284 ILE A CA  1 
ATOM   915  C C   . ILE A 1 303 ? -6.133  73.748  94.385  1.00 58.25  ?  284 ILE A C   1 
ATOM   916  O O   . ILE A 1 303 ? -5.753  72.597  94.601  1.00 55.89  ?  284 ILE A O   1 
ATOM   917  C CB  . ILE A 1 303 ? -4.203  75.141  95.205  1.00 56.26  ?  284 ILE A CB  1 
ATOM   918  C CG1 . ILE A 1 303 ? -3.797  76.167  96.263  1.00 57.65  ?  284 ILE A CG1 1 
ATOM   919  C CG2 . ILE A 1 303 ? -3.837  75.580  93.794  1.00 50.87  ?  284 ILE A CG2 1 
ATOM   920  C CD1 . ILE A 1 303 ? -2.344  76.549  96.243  1.00 51.15  ?  284 ILE A CD1 1 
ATOM   921  N N   . GLY A 1 304 ? -6.954  74.062  93.389  1.00 61.05  ?  285 GLY A N   1 
ATOM   922  C CA  . GLY A 1 304 ? -7.450  73.091  92.427  1.00 56.71  ?  285 GLY A CA  1 
ATOM   923  C C   . GLY A 1 304 ? -8.771  72.455  92.812  1.00 61.46  ?  285 GLY A C   1 
ATOM   924  O O   . GLY A 1 304 ? -8.940  72.020  93.954  1.00 59.11  ?  285 GLY A O   1 
ATOM   925  N N   . SER A 1 305 ? -9.721  72.379  91.884  1.00 61.85  ?  286 SER A N   1 
ATOM   926  C CA  . SER A 1 305 ? -10.983 71.688  92.143  1.00 65.84  ?  286 SER A CA  1 
ATOM   927  C C   . SER A 1 305 ? -11.113 70.444  91.266  1.00 75.61  ?  286 SER A C   1 
ATOM   928  O O   . SER A 1 305 ? -12.210 70.087  90.814  1.00 70.63  ?  286 SER A O   1 
ATOM   929  C CB  . SER A 1 305 ? -12.180 72.603  91.932  1.00 64.42  ?  286 SER A CB  1 
ATOM   930  O OG  . SER A 1 305 ? -12.231 72.981  90.561  1.00 76.30  ?  286 SER A OG  1 
ATOM   931  N N   . GLY A 1 306 ? -9.983  69.782  90.996  1.00 72.26  ?  287 GLY A N   1 
ATOM   932  C CA  . GLY A 1 306 ? -10.037 68.425  90.543  1.00 60.02  ?  287 GLY A CA  1 
ATOM   933  C C   . GLY A 1 306 ? -10.615 67.563  91.641  1.00 68.62  ?  287 GLY A C   1 
ATOM   934  O O   . GLY A 1 306 ? -10.847 68.011  92.762  1.00 68.04  ?  287 GLY A O   1 
ATOM   935  N N   . VAL A 1 307 ? -10.819 66.284  91.315  1.00 70.53  ?  288 VAL A N   1 
ATOM   936  C CA  . VAL A 1 307 ? -11.546 65.400  92.218  1.00 59.77  ?  288 VAL A CA  1 
ATOM   937  C C   . VAL A 1 307 ? -10.866 65.352  93.576  1.00 60.31  ?  288 VAL A C   1 
ATOM   938  O O   . VAL A 1 307 ? -11.539 65.295  94.612  1.00 65.69  ?  288 VAL A O   1 
ATOM   939  C CB  . VAL A 1 307 ? -11.700 63.996  91.579  1.00 64.07  ?  288 VAL A CB  1 
ATOM   940  C CG1 . VAL A 1 307 ? -12.131 62.936  92.594  1.00 60.92  ?  288 VAL A CG1 1 
ATOM   941  C CG2 . VAL A 1 307 ? -12.674 64.037  90.416  1.00 56.54  ?  288 VAL A CG2 1 
ATOM   942  N N   . SER A 1 308 ? -9.532  65.389  93.620  1.00 56.67  ?  289 SER A N   1 
ATOM   943  C CA  . SER A 1 308 ? -8.909  65.306  94.941  1.00 63.90  ?  289 SER A CA  1 
ATOM   944  C C   . SER A 1 308 ? -9.270  66.536  95.777  1.00 67.87  ?  289 SER A C   1 
ATOM   945  O O   . SER A 1 308 ? -9.677  66.409  96.942  1.00 64.32  ?  289 SER A O   1 
ATOM   946  C CB  . SER A 1 308 ? -7.390  65.122  94.846  1.00 60.83  ?  289 SER A CB  1 
ATOM   947  O OG  . SER A 1 308 ? -6.742  66.160  94.139  1.00 62.19  ?  289 SER A OG  1 
ATOM   948  N N   . GLY A 1 309 ? -9.170  67.736  95.180  1.00 65.10  ?  290 GLY A N   1 
ATOM   949  C CA  . GLY A 1 309 ? -9.588  68.955  95.844  1.00 61.68  ?  290 GLY A CA  1 
ATOM   950  C C   . GLY A 1 309 ? -11.020 68.864  96.334  1.00 67.49  ?  290 GLY A C   1 
ATOM   951  O O   . GLY A 1 309 ? -11.284 69.020  97.528  1.00 75.20  ?  290 GLY A O   1 
ATOM   952  N N   . LEU A 1 310 ? -11.948 68.577  95.421  1.00 68.12  ?  291 LEU A N   1 
ATOM   953  C CA  . LEU A 1 310 ? -13.364 68.467  95.771  1.00 65.90  ?  291 LEU A CA  1 
ATOM   954  C C   . LEU A 1 310 ? -13.591 67.528  96.938  1.00 65.26  ?  291 LEU A C   1 
ATOM   955  O O   . LEU A 1 310 ? -14.367 67.834  97.849  1.00 68.90  ?  291 LEU A O   1 
ATOM   956  C CB  . LEU A 1 310 ? -14.144 67.984  94.556  1.00 66.30  ?  291 LEU A CB  1 
ATOM   957  C CG  . LEU A 1 310 ? -14.195 68.994  93.429  1.00 67.09  ?  291 LEU A CG  1 
ATOM   958  C CD1 . LEU A 1 310 ? -14.651 68.338  92.174  1.00 69.18  ?  291 LEU A CD1 1 
ATOM   959  C CD2 . LEU A 1 310 ? -15.219 70.029  93.852  1.00 73.00  ?  291 LEU A CD2 1 
ATOM   960  N N   . ALA A 1 311 ? -12.944 66.373  96.923  1.00 65.07  ?  292 ALA A N   1 
ATOM   961  C CA  . ALA A 1 311 ? -13.281 65.378  97.930  1.00 67.98  ?  292 ALA A CA  1 
ATOM   962  C C   . ALA A 1 311 ? -12.788 65.806  99.300  1.00 69.57  ?  292 ALA A C   1 
ATOM   963  O O   . ALA A 1 311 ? -13.444 65.531  100.313 1.00 71.49  ?  292 ALA A O   1 
ATOM   964  C CB  . ALA A 1 311 ? -12.700 64.016  97.557  1.00 71.19  ?  292 ALA A CB  1 
ATOM   965  N N   . ALA A 1 312 ? -11.623 66.457  99.353  1.00 68.19  ?  293 ALA A N   1 
ATOM   966  C CA  . ALA A 1 312 ? -11.173 67.052  100.605 1.00 68.57  ?  293 ALA A CA  1 
ATOM   967  C C   . ALA A 1 312 ? -12.137 68.140  101.051 1.00 72.07  ?  293 ALA A C   1 
ATOM   968  O O   . ALA A 1 312 ? -12.603 68.148  102.199 1.00 71.39  ?  293 ALA A O   1 
ATOM   969  C CB  . ALA A 1 312 ? -9.774  67.631  100.445 1.00 61.89  ?  293 ALA A CB  1 
ATOM   970  N N   . ALA A 1 313 ? -12.455 69.063  100.143 1.00 68.23  ?  294 ALA A N   1 
ATOM   971  C CA  . ALA A 1 313 ? -13.281 70.202  100.502 1.00 67.48  ?  294 ALA A CA  1 
ATOM   972  C C   . ALA A 1 313 ? -14.594 69.744  101.116 1.00 70.69  ?  294 ALA A C   1 
ATOM   973  O O   . ALA A 1 313 ? -15.012 70.271  102.150 1.00 71.91  ?  294 ALA A O   1 
ATOM   974  C CB  . ALA A 1 313 ? -13.518 71.084  99.279  1.00 62.84  ?  294 ALA A CB  1 
ATOM   975  N N   . ARG A 1 314 ? -15.239 68.731  100.521 1.00 70.98  ?  295 ARG A N   1 
ATOM   976  C CA  . ARG A 1 314 ? -16.489 68.230  101.098 1.00 70.41  ?  295 ARG A CA  1 
ATOM   977  C C   . ARG A 1 314 ? -16.261 67.651  102.481 1.00 70.59  ?  295 ARG A C   1 
ATOM   978  O O   . ARG A 1 314 ? -17.083 67.841  103.385 1.00 73.03  ?  295 ARG A O   1 
ATOM   979  C CB  . ARG A 1 314 ? -17.134 67.173  100.207 1.00 65.10  ?  295 ARG A CB  1 
ATOM   980  C CG  . ARG A 1 314 ? -17.977 67.740  99.116  1.00 73.49  ?  295 ARG A CG  1 
ATOM   981  C CD  . ARG A 1 314 ? -18.839 66.663  98.532  1.00 72.04  ?  295 ARG A CD  1 
ATOM   982  N NE  . ARG A 1 314 ? -20.107 66.513  99.219  1.00 74.25  ?  295 ARG A NE  1 
ATOM   983  C CZ  . ARG A 1 314 ? -21.189 67.235  98.940  1.00 81.25  ?  295 ARG A CZ  1 
ATOM   984  N NH1 . ARG A 1 314 ? -21.143 68.176  97.999  1.00 76.19  ?  295 ARG A NH1 1 
ATOM   985  N NH2 . ARG A 1 314 ? -22.316 67.028  99.615  1.00 90.94  ?  295 ARG A NH2 1 
ATOM   986  N N   . GLN A 1 315 ? -15.162 66.929  102.668 1.00 67.32  ?  296 GLN A N   1 
ATOM   987  C CA  . GLN A 1 315 ? -14.894 66.386  103.989 1.00 70.44  ?  296 GLN A CA  1 
ATOM   988  C C   . GLN A 1 315 ? -14.673 67.510  104.990 1.00 72.69  ?  296 GLN A C   1 
ATOM   989  O O   . GLN A 1 315 ? -15.315 67.547  106.041 1.00 75.92  ?  296 GLN A O   1 
ATOM   990  C CB  . GLN A 1 315 ? -13.692 65.440  103.946 1.00 71.94  ?  296 GLN A CB  1 
ATOM   991  C CG  . GLN A 1 315 ? -13.972 64.063  103.363 1.00 71.29  ?  296 GLN A CG  1 
ATOM   992  C CD  . GLN A 1 315 ? -15.040 63.341  104.110 1.00 75.91  ?  296 GLN A CD  1 
ATOM   993  O OE1 . GLN A 1 315 ? -16.228 63.529  103.831 1.00 79.11  ?  296 GLN A OE1 1 
ATOM   994  N NE2 . GLN A 1 315 ? -14.641 62.516  105.091 1.00 78.27  ?  296 GLN A NE2 1 
ATOM   995  N N   . LEU A 1 316 ? -13.774 68.446  104.669 1.00 70.32  ?  297 LEU A N   1 
ATOM   996  C CA  . LEU A 1 316 ? -13.450 69.528  105.593 1.00 68.63  ?  297 LEU A CA  1 
ATOM   997  C C   . LEU A 1 316 ? -14.705 70.308  105.969 1.00 76.16  ?  297 LEU A C   1 
ATOM   998  O O   . LEU A 1 316 ? -15.002 70.503  107.156 1.00 78.36  ?  297 LEU A O   1 
ATOM   999  C CB  . LEU A 1 316 ? -12.385 70.446  104.973 1.00 58.93  ?  297 LEU A CB  1 
ATOM   1000 C CG  . LEU A 1 316 ? -11.023 69.757  104.938 1.00 58.44  ?  297 LEU A CG  1 
ATOM   1001 C CD1 . LEU A 1 316 ? -9.947  70.554  104.224 1.00 50.24  ?  297 LEU A CD1 1 
ATOM   1002 C CD2 . LEU A 1 316 ? -10.591 69.338  106.341 1.00 56.81  ?  297 LEU A CD2 1 
ATOM   1003 N N   . GLN A 1 317 ? -15.481 70.723  104.971 1.00 70.83  ?  298 GLN A N   1 
ATOM   1004 C CA  . GLN A 1 317 ? -16.726 71.408  105.260 1.00 65.27  ?  298 GLN A CA  1 
ATOM   1005 C C   . GLN A 1 317 ? -17.674 70.548  106.085 1.00 74.28  ?  298 GLN A C   1 
ATOM   1006 O O   . GLN A 1 317 ? -18.403 71.075  106.924 1.00 87.51  ?  298 GLN A O   1 
ATOM   1007 C CB  . GLN A 1 317 ? -17.387 71.845  103.969 1.00 68.75  ?  298 GLN A CB  1 
ATOM   1008 C CG  . GLN A 1 317 ? -18.661 72.579  104.172 1.00 72.14  ?  298 GLN A CG  1 
ATOM   1009 C CD  . GLN A 1 317 ? -19.316 73.005  102.874 1.00 80.65  ?  298 GLN A CD  1 
ATOM   1010 O OE1 . GLN A 1 317 ? -20.097 72.245  102.300 1.00 89.94  ?  298 GLN A OE1 1 
ATOM   1011 N NE2 . GLN A 1 317 ? -19.017 74.227  102.410 1.00 72.12  ?  298 GLN A NE2 1 
ATOM   1012 N N   . SER A 1 318 ? -17.677 69.232  105.904 1.00 77.73  ?  299 SER A N   1 
ATOM   1013 C CA  . SER A 1 318 ? -18.551 68.434  106.763 1.00 77.87  ?  299 SER A CA  1 
ATOM   1014 C C   . SER A 1 318 ? -17.983 68.256  108.160 1.00 76.69  ?  299 SER A C   1 
ATOM   1015 O O   . SER A 1 318 ? -18.643 67.656  109.012 1.00 80.29  ?  299 SER A O   1 
ATOM   1016 C CB  . SER A 1 318 ? -18.820 67.039  106.178 1.00 87.23  ?  299 SER A CB  1 
ATOM   1017 O OG  . SER A 1 318 ? -17.708 66.149  106.326 1.00 84.77  ?  299 SER A OG  1 
ATOM   1018 N N   . PHE A 1 319 ? -16.764 68.706  108.405 1.00 74.30  ?  300 PHE A N   1 
ATOM   1019 C CA  . PHE A 1 319 ? -16.147 68.559  109.712 1.00 77.00  ?  300 PHE A CA  1 
ATOM   1020 C C   . PHE A 1 319 ? -16.251 69.833  110.527 1.00 86.62  ?  300 PHE A C   1 
ATOM   1021 O O   . PHE A 1 319 ? -15.853 69.852  111.702 1.00 83.16  ?  300 PHE A O   1 
ATOM   1022 C CB  . PHE A 1 319 ? -14.678 68.165  109.568 1.00 77.20  ?  300 PHE A CB  1 
ATOM   1023 C CG  . PHE A 1 319 ? -14.470 66.765  109.080 1.00 79.92  ?  300 PHE A CG  1 
ATOM   1024 C CD1 . PHE A 1 319 ? -15.545 65.899  108.945 1.00 80.25  ?  300 PHE A CD1 1 
ATOM   1025 C CD2 . PHE A 1 319 ? -13.197 66.313  108.763 1.00 77.00  ?  300 PHE A CD2 1 
ATOM   1026 C CE1 . PHE A 1 319 ? -15.363 64.623  108.506 1.00 77.47  ?  300 PHE A CE1 1 
ATOM   1027 C CE2 . PHE A 1 319 ? -13.004 65.042  108.323 1.00 73.86  ?  300 PHE A CE2 1 
ATOM   1028 C CZ  . PHE A 1 319 ? -14.089 64.186  108.198 1.00 80.66  ?  300 PHE A CZ  1 
ATOM   1029 N N   . GLY A 1 320 ? -16.778 70.888  109.922 1.00 79.94  ?  301 GLY A N   1 
ATOM   1030 C CA  . GLY A 1 320 ? -16.924 72.155  110.568 1.00 76.05  ?  301 GLY A CA  1 
ATOM   1031 C C   . GLY A 1 320 ? -15.874 73.161  110.184 1.00 84.34  ?  301 GLY A C   1 
ATOM   1032 O O   . GLY A 1 320 ? -15.566 74.043  110.993 1.00 93.60  ?  301 GLY A O   1 
ATOM   1033 N N   . MET A 1 321 ? -15.306 73.065  108.994 1.00 78.47  ?  302 MET A N   1 
ATOM   1034 C CA  . MET A 1 321 ? -14.245 73.978  108.627 1.00 72.72  ?  302 MET A CA  1 
ATOM   1035 C C   . MET A 1 321 ? -14.744 74.910  107.537 1.00 77.00  ?  302 MET A C   1 
ATOM   1036 O O   . MET A 1 321 ? -15.744 74.634  106.863 1.00 78.46  ?  302 MET A O   1 
ATOM   1037 C CB  . MET A 1 321 ? -12.998 73.204  108.208 1.00 69.43  ?  302 MET A CB  1 
ATOM   1038 C CG  . MET A 1 321 ? -12.259 72.732  109.433 1.00 74.95  ?  302 MET A CG  1 
ATOM   1039 S SD  . MET A 1 321 ? -10.643 72.023  109.164 1.00 73.30  ?  302 MET A SD  1 
ATOM   1040 C CE  . MET A 1 321 ? -9.560  73.374  109.629 1.00 73.52  ?  302 MET A CE  1 
ATOM   1041 N N   . ASP A 1 322 ? -14.088 76.060  107.432 1.00 73.36  ?  303 ASP A N   1 
ATOM   1042 C CA  . ASP A 1 322 ? -14.410 77.029  106.397 1.00 77.96  ?  303 ASP A CA  1 
ATOM   1043 C C   . ASP A 1 322 ? -13.454 76.763  105.250 1.00 81.44  ?  303 ASP A C   1 
ATOM   1044 O O   . ASP A 1 322 ? -12.230 76.855  105.422 1.00 80.28  ?  303 ASP A O   1 
ATOM   1045 C CB  . ASP A 1 322 ? -14.289 78.462  106.924 1.00 80.26  ?  303 ASP A CB  1 
ATOM   1046 C CG  . ASP A 1 322 ? -14.495 79.557  105.841 1.00 92.35  ?  303 ASP A CG  1 
ATOM   1047 O OD1 . ASP A 1 322 ? -14.628 80.733  106.266 1.00 97.60  ?  303 ASP A OD1 1 
ATOM   1048 O OD2 . ASP A 1 322 ? -14.498 79.293  104.597 1.00 93.75  ?  303 ASP A OD2 1 
ATOM   1049 N N   . VAL A 1 323 ? -14.005 76.416  104.090 1.00 80.04  ?  304 VAL A N   1 
ATOM   1050 C CA  . VAL A 1 323 ? -13.197 75.938  102.981 1.00 75.63  ?  304 VAL A CA  1 
ATOM   1051 C C   . VAL A 1 323 ? -13.487 76.764  101.750 1.00 69.96  ?  304 VAL A C   1 
ATOM   1052 O O   . VAL A 1 323 ? -14.644 77.085  101.462 1.00 75.11  ?  304 VAL A O   1 
ATOM   1053 C CB  . VAL A 1 323 ? -13.457 74.455  102.686 1.00 67.29  ?  304 VAL A CB  1 
ATOM   1054 C CG1 . VAL A 1 323 ? -12.516 74.013  101.639 1.00 66.89  ?  304 VAL A CG1 1 
ATOM   1055 C CG2 . VAL A 1 323 ? -13.306 73.636  103.943 1.00 71.58  ?  304 VAL A CG2 1 
ATOM   1056 N N   . THR A 1 324 ? -12.436 77.081  101.011 1.00 64.71  ?  305 THR A N   1 
ATOM   1057 C CA  . THR A 1 324 ? -12.564 77.761  99.736  1.00 72.13  ?  305 THR A CA  1 
ATOM   1058 C C   . THR A 1 324 ? -11.595 77.102  98.759  1.00 71.62  ?  305 THR A C   1 
ATOM   1059 O O   . THR A 1 324 ? -10.443 76.824  99.115  1.00 72.48  ?  305 THR A O   1 
ATOM   1060 C CB  . THR A 1 324 ? -12.288 79.276  99.903  1.00 74.75  ?  305 THR A CB  1 
ATOM   1061 O OG1 . THR A 1 324 ? -13.344 79.855  100.678 1.00 78.77  ?  305 THR A OG1 1 
ATOM   1062 C CG2 . THR A 1 324 ? -12.212 80.013  98.559  1.00 68.57  ?  305 THR A CG2 1 
ATOM   1063 N N   . LEU A 1 325 ? -12.063 76.833  97.541  1.00 67.67  ?  306 LEU A N   1 
ATOM   1064 C CA  . LEU A 1 325 ? -11.245 76.228  96.504  1.00 66.88  ?  306 LEU A CA  1 
ATOM   1065 C C   . LEU A 1 325 ? -10.923 77.259  95.444  1.00 68.32  ?  306 LEU A C   1 
ATOM   1066 O O   . LEU A 1 325 ? -11.808 77.984  94.979  1.00 74.03  ?  306 LEU A O   1 
ATOM   1067 C CB  . LEU A 1 325 ? -11.943 75.041  95.833  1.00 67.72  ?  306 LEU A CB  1 
ATOM   1068 C CG  . LEU A 1 325 ? -12.317 73.865  96.709  1.00 64.06  ?  306 LEU A CG  1 
ATOM   1069 C CD1 . LEU A 1 325 ? -13.718 74.119  97.210  1.00 68.80  ?  306 LEU A CD1 1 
ATOM   1070 C CD2 . LEU A 1 325 ? -12.252 72.566  95.931  1.00 65.40  ?  306 LEU A CD2 1 
ATOM   1071 N N   . LEU A 1 326 ? -9.663  77.279  95.038  1.00 61.19  ?  307 LEU A N   1 
ATOM   1072 C CA  . LEU A 1 326 ? -9.161  78.158  94.001  1.00 59.96  ?  307 LEU A CA  1 
ATOM   1073 C C   . LEU A 1 326 ? -8.893  77.312  92.762  1.00 69.17  ?  307 LEU A C   1 
ATOM   1074 O O   . LEU A 1 326 ? -8.149  76.329  92.838  1.00 71.14  ?  307 LEU A O   1 
ATOM   1075 C CB  . LEU A 1 326 ? -7.894  78.842  94.500  1.00 60.43  ?  307 LEU A CB  1 
ATOM   1076 C CG  . LEU A 1 326 ? -8.054  80.150  95.289  1.00 65.73  ?  307 LEU A CG  1 
ATOM   1077 C CD1 . LEU A 1 326 ? -9.176  80.109  96.317  1.00 68.10  ?  307 LEU A CD1 1 
ATOM   1078 C CD2 . LEU A 1 326 ? -6.770  80.435  96.023  1.00 62.91  ?  307 LEU A CD2 1 
ATOM   1079 N N   . GLU A 1 327 ? -9.490  77.682  91.627  1.00 67.92  ?  308 GLU A N   1 
ATOM   1080 C CA  . GLU A 1 327 ? -9.490  76.844  90.426  1.00 62.44  ?  308 GLU A CA  1 
ATOM   1081 C C   . GLU A 1 327 ? -9.125  77.675  89.211  1.00 64.57  ?  308 GLU A C   1 
ATOM   1082 O O   . GLU A 1 327 ? -9.846  78.614  88.872  1.00 72.83  ?  308 GLU A O   1 
ATOM   1083 C CB  . GLU A 1 327 ? -10.866 76.208  90.211  1.00 64.57  ?  308 GLU A CB  1 
ATOM   1084 C CG  . GLU A 1 327 ? -11.016 75.428  88.912  1.00 69.82  ?  308 GLU A CG  1 
ATOM   1085 C CD  . GLU A 1 327 ? -9.827  74.498  88.585  1.00 69.77  ?  308 GLU A CD  1 
ATOM   1086 O OE1 . GLU A 1 327 ? -9.536  73.551  89.390  1.00 67.92  ?  308 GLU A OE1 1 
ATOM   1087 O OE2 . GLU A 1 327 ? -9.220  74.706  87.501  1.00 58.31  ?  308 GLU A OE2 1 
ATOM   1088 N N   . ALA A 1 328 ? -8.034  77.314  88.534  1.00 59.31  ?  309 ALA A N   1 
ATOM   1089 C CA  . ALA A 1 328 ? -7.580  78.104  87.389  1.00 63.08  ?  309 ALA A CA  1 
ATOM   1090 C C   . ALA A 1 328 ? -8.577  78.062  86.225  1.00 71.78  ?  309 ALA A C   1 
ATOM   1091 O O   . ALA A 1 328 ? -8.842  79.090  85.586  1.00 70.74  ?  309 ALA A O   1 
ATOM   1092 C CB  . ALA A 1 328 ? -6.197  77.621  86.941  1.00 60.62  ?  309 ALA A CB  1 
ATOM   1093 N N   . ARG A 1 329 ? -9.134  76.884  85.931  1.00 75.91  ?  310 ARG A N   1 
ATOM   1094 C CA  . ARG A 1 329 ? -10.068 76.725  84.824  1.00 75.14  ?  310 ARG A CA  1 
ATOM   1095 C C   . ARG A 1 329 ? -11.400 77.423  85.115  1.00 78.27  ?  310 ARG A C   1 
ATOM   1096 O O   . ARG A 1 329 ? -11.675 77.901  86.228  1.00 74.56  ?  310 ARG A O   1 
ATOM   1097 C CB  . ARG A 1 329 ? -10.363 75.247  84.545  1.00 76.26  ?  310 ARG A CB  1 
ATOM   1098 C CG  . ARG A 1 329 ? -9.198  74.401  84.055  1.00 72.74  ?  310 ARG A CG  1 
ATOM   1099 C CD  . ARG A 1 329 ? -9.582  72.926  84.062  1.00 60.40  ?  310 ARG A CD  1 
ATOM   1100 N NE  . ARG A 1 329 ? -8.392  72.091  84.150  1.00 67.15  ?  310 ARG A NE  1 
ATOM   1101 C CZ  . ARG A 1 329 ? -7.602  71.778  83.118  1.00 67.01  ?  310 ARG A CZ  1 
ATOM   1102 N NH1 . ARG A 1 329 ? -7.869  72.219  81.902  1.00 58.73  ?  310 ARG A NH1 1 
ATOM   1103 N NH2 . ARG A 1 329 ? -6.533  71.013  83.306  1.00 65.71  ?  310 ARG A NH2 1 
ATOM   1104 N N   . ASP A 1 330 ? -12.250 77.431  84.090  1.00 76.71  ?  311 ASP A N   1 
ATOM   1105 C CA  . ASP A 1 330 ? -13.637 77.828  84.217  1.00 72.38  ?  311 ASP A CA  1 
ATOM   1106 C C   . ASP A 1 330 ? -14.557 76.665  84.543  1.00 70.76  ?  311 ASP A C   1 
ATOM   1107 O O   . ASP A 1 330 ? -15.762 76.764  84.313  1.00 75.84  ?  311 ASP A O   1 
ATOM   1108 C CB  . ASP A 1 330 ? -14.080 78.528  82.941  1.00 71.11  ?  311 ASP A CB  1 
ATOM   1109 C CG  . ASP A 1 330 ? -13.623 77.796  81.703  1.00 88.26  ?  311 ASP A CG  1 
ATOM   1110 O OD1 . ASP A 1 330 ? -12.967 76.738  81.885  1.00 86.70  ?  311 ASP A OD1 1 
ATOM   1111 O OD2 . ASP A 1 330 ? -13.847 78.302  80.568  1.00 91.58  ?  311 ASP A OD2 1 
ATOM   1112 N N   . ARG A 1 331 ? -14.034 75.582  85.106  1.00 68.63  ?  312 ARG A N   1 
ATOM   1113 C CA  . ARG A 1 331 ? -14.890 74.446  85.408  1.00 67.44  ?  312 ARG A CA  1 
ATOM   1114 C C   . ARG A 1 331 ? -14.226 73.602  86.477  1.00 70.36  ?  312 ARG A C   1 
ATOM   1115 O O   . ARG A 1 331 ? -12.994 73.541  86.565  1.00 74.69  ?  312 ARG A O   1 
ATOM   1116 C CB  . ARG A 1 331 ? -15.147 73.585  84.164  1.00 71.19  ?  312 ARG A CB  1 
ATOM   1117 C CG  . ARG A 1 331 ? -13.855 73.133  83.507  1.00 70.09  ?  312 ARG A CG  1 
ATOM   1118 C CD  . ARG A 1 331 ? -14.031 72.179  82.348  1.00 67.06  ?  312 ARG A CD  1 
ATOM   1119 N NE  . ARG A 1 331 ? -12.722 71.708  81.901  1.00 65.44  ?  312 ARG A NE  1 
ATOM   1120 C CZ  . ARG A 1 331 ? -12.093 70.679  82.454  1.00 62.57  ?  312 ARG A CZ  1 
ATOM   1121 N NH1 . ARG A 1 331 ? -12.681 70.020  83.439  1.00 64.70  ?  312 ARG A NH1 1 
ATOM   1122 N NH2 . ARG A 1 331 ? -10.888 70.308  82.032  1.00 59.00  ?  312 ARG A NH2 1 
ATOM   1123 N N   . VAL A 1 332 ? -15.053 72.918  87.264  1.00 65.80  ?  313 VAL A N   1 
ATOM   1124 C CA  . VAL A 1 332 ? -14.544 71.877  88.148  1.00 73.02  ?  313 VAL A CA  1 
ATOM   1125 C C   . VAL A 1 332 ? -14.163 70.632  87.339  1.00 72.44  ?  313 VAL A C   1 
ATOM   1126 O O   . VAL A 1 332 ? -14.358 70.585  86.118  1.00 71.97  ?  313 VAL A O   1 
ATOM   1127 C CB  . VAL A 1 332 ? -15.590 71.539  89.219  1.00 72.34  ?  313 VAL A CB  1 
ATOM   1128 C CG1 . VAL A 1 332 ? -15.967 72.773  89.947  1.00 65.96  ?  313 VAL A CG1 1 
ATOM   1129 C CG2 . VAL A 1 332 ? -16.814 70.923  88.569  1.00 75.33  ?  313 VAL A CG2 1 
ATOM   1130 N N   . GLY A 1 333 ? -13.629 69.611  88.013  1.00 68.74  ?  314 GLY A N   1 
ATOM   1131 C CA  . GLY A 1 333 ? -13.291 68.350  87.371  1.00 67.23  ?  314 GLY A CA  1 
ATOM   1132 C C   . GLY A 1 333 ? -11.809 68.105  87.156  1.00 65.30  ?  314 GLY A C   1 
ATOM   1133 O O   . GLY A 1 333 ? -11.297 66.992  87.361  1.00 70.21  ?  314 GLY A O   1 
ATOM   1134 N N   . GLY A 1 334 ? -11.095 69.142  86.761  1.00 64.93  ?  315 GLY A N   1 
ATOM   1135 C CA  . GLY A 1 334 ? -9.692  68.944  86.497  1.00 65.96  ?  315 GLY A CA  1 
ATOM   1136 C C   . GLY A 1 334 ? -9.514  68.053  85.293  1.00 67.14  ?  315 GLY A C   1 
ATOM   1137 O O   . GLY A 1 334 ? -10.042 68.338  84.205  1.00 64.27  ?  315 GLY A O   1 
ATOM   1138 N N   . ARG A 1 335 ? -8.784  66.959  85.488  1.00 65.60  ?  316 ARG A N   1 
ATOM   1139 C CA  . ARG A 1 335 ? -8.570  65.974  84.439  1.00 59.77  ?  316 ARG A CA  1 
ATOM   1140 C C   . ARG A 1 335 ? -9.767  65.037  84.266  1.00 68.61  ?  316 ARG A C   1 
ATOM   1141 O O   . ARG A 1 335 ? -9.663  64.064  83.518  1.00 73.10  ?  316 ARG A O   1 
ATOM   1142 C CB  . ARG A 1 335 ? -7.292  65.182  84.725  1.00 54.16  ?  316 ARG A CB  1 
ATOM   1143 C CG  . ARG A 1 335 ? -6.053  65.958  84.417  1.00 47.72  ?  316 ARG A CG  1 
ATOM   1144 C CD  . ARG A 1 335 ? -4.837  65.329  85.037  1.00 52.24  ?  316 ARG A CD  1 
ATOM   1145 N NE  . ARG A 1 335 ? -4.671  65.595  86.463  1.00 59.97  ?  316 ARG A NE  1 
ATOM   1146 C CZ  . ARG A 1 335 ? -3.607  65.201  87.160  1.00 62.30  ?  316 ARG A CZ  1 
ATOM   1147 N NH1 . ARG A 1 335 ? -2.652  64.512  86.552  1.00 63.50  ?  316 ARG A NH1 1 
ATOM   1148 N NH2 . ARG A 1 335 ? -3.492  65.467  88.456  1.00 61.30  ?  316 ARG A NH2 1 
ATOM   1149 N N   . VAL A 1 336 ? -10.888 65.290  84.937  1.00 65.53  ?  317 VAL A N   1 
ATOM   1150 C CA  . VAL A 1 336 ? -12.177 64.735  84.540  1.00 56.62  ?  317 VAL A CA  1 
ATOM   1151 C C   . VAL A 1 336 ? -12.882 65.809  83.707  1.00 70.87  ?  317 VAL A C   1 
ATOM   1152 O O   . VAL A 1 336 ? -13.671 66.629  84.200  1.00 73.22  ?  317 VAL A O   1 
ATOM   1153 C CB  . VAL A 1 336 ? -12.993 64.290  85.728  1.00 56.41  ?  317 VAL A CB  1 
ATOM   1154 C CG1 . VAL A 1 336 ? -14.377 63.902  85.282  1.00 65.34  ?  317 VAL A CG1 1 
ATOM   1155 C CG2 . VAL A 1 336 ? -12.288 63.153  86.367  1.00 60.50  ?  317 VAL A CG2 1 
ATOM   1156 N N   . ALA A 1 337 ? -12.564 65.805  82.416  1.00 69.33  ?  318 ALA A N   1 
ATOM   1157 C CA  . ALA A 1 337 ? -13.170 66.637  81.395  1.00 67.62  ?  318 ALA A CA  1 
ATOM   1158 C C   . ALA A 1 337 ? -14.198 65.838  80.601  1.00 69.66  ?  318 ALA A C   1 
ATOM   1159 O O   . ALA A 1 337 ? -13.966 64.681  80.258  1.00 85.16  ?  318 ALA A O   1 
ATOM   1160 C CB  . ALA A 1 337 ? -12.079 67.167  80.459  1.00 66.58  ?  318 ALA A CB  1 
ATOM   1161 N N   . THR A 1 338 ? -15.327 66.457  80.306  1.00 71.17  ?  319 THR A N   1 
ATOM   1162 C CA  . THR A 1 338 ? -16.380 65.851  79.512  1.00 74.78  ?  319 THR A CA  1 
ATOM   1163 C C   . THR A 1 338 ? -16.840 66.836  78.452  1.00 80.66  ?  319 THR A C   1 
ATOM   1164 O O   . THR A 1 338 ? -17.193 67.977  78.767  1.00 85.41  ?  319 THR A O   1 
ATOM   1165 C CB  . THR A 1 338 ? -17.558 65.445  80.387  1.00 80.34  ?  319 THR A CB  1 
ATOM   1166 O OG1 . THR A 1 338 ? -17.161 64.381  81.260  1.00 83.86  ?  319 THR A OG1 1 
ATOM   1167 C CG2 . THR A 1 338 ? -18.716 64.996  79.537  1.00 83.57  ?  319 THR A CG2 1 
ATOM   1168 N N   . PHE A 1 339 ? -16.822 66.397  77.200  1.00 89.90  ?  320 PHE A N   1 
ATOM   1169 C CA  . PHE A 1 339 ? -17.310 67.193  76.084  1.00 85.32  ?  320 PHE A CA  1 
ATOM   1170 C C   . PHE A 1 339 ? -18.813 67.012  75.960  1.00 88.56  ?  320 PHE A C   1 
ATOM   1171 O O   . PHE A 1 339 ? -19.324 65.897  76.104  1.00 86.84  ?  320 PHE A O   1 
ATOM   1172 C CB  . PHE A 1 339 ? -16.614 66.753  74.804  1.00 83.31  ?  320 PHE A CB  1 
ATOM   1173 C CG  . PHE A 1 339 ? -17.165 67.365  73.553  1.00 92.66  ?  320 PHE A CG  1 
ATOM   1174 C CD1 . PHE A 1 339 ? -16.944 68.701  73.262  1.00 91.40  ?  320 PHE A CD1 1 
ATOM   1175 C CD2 . PHE A 1 339 ? -17.864 66.591  72.639  1.00 90.98  ?  320 PHE A CD2 1 
ATOM   1176 C CE1 . PHE A 1 339 ? -17.434 69.265  72.097  1.00 93.17  ?  320 PHE A CE1 1 
ATOM   1177 C CE2 . PHE A 1 339 ? -18.350 67.147  71.479  1.00 93.01  ?  320 PHE A CE2 1 
ATOM   1178 C CZ  . PHE A 1 339 ? -18.134 68.496  71.209  1.00 95.41  ?  320 PHE A CZ  1 
ATOM   1179 N N   . ARG A 1 340 ? -19.527 68.118  75.727  1.00 89.73  ?  321 ARG A N   1 
ATOM   1180 C CA  . ARG A 1 340 ? -20.974 68.074  75.542  1.00 86.90  ?  321 ARG A CA  1 
ATOM   1181 C C   . ARG A 1 340 ? -21.393 69.097  74.498  1.00 95.34  ?  321 ARG A C   1 
ATOM   1182 O O   . ARG A 1 340 ? -21.044 70.278  74.602  1.00 96.85  ?  321 ARG A O   1 
ATOM   1183 C CB  . ARG A 1 340 ? -21.720 68.312  76.858  1.00 78.85  ?  321 ARG A CB  1 
ATOM   1184 C CG  . ARG A 1 340 ? -21.528 67.187  77.875  1.00 85.63  ?  321 ARG A CG  1 
ATOM   1185 C CD  . ARG A 1 340 ? -22.042 67.528  79.266  1.00 79.87  ?  321 ARG A CD  1 
ATOM   1186 N NE  . ARG A 1 340 ? -21.622 66.555  80.275  1.00 78.99  ?  321 ARG A NE  1 
ATOM   1187 C CZ  . ARG A 1 340 ? -22.336 65.488  80.624  1.00 88.13  ?  321 ARG A CZ  1 
ATOM   1188 N NH1 . ARG A 1 340 ? -23.510 65.265  80.033  1.00 88.46  ?  321 ARG A NH1 1 
ATOM   1189 N NH2 . ARG A 1 340 ? -21.878 64.645  81.555  1.00 86.89  ?  321 ARG A NH2 1 
ATOM   1190 N N   . LYS A 1 341 ? -22.123 68.619  73.485  1.00 101.34 ?  322 LYS A N   1 
ATOM   1191 C CA  . LYS A 1 341 ? -22.722 69.447  72.435  1.00 100.00 ?  322 LYS A CA  1 
ATOM   1192 C C   . LYS A 1 341 ? -23.908 68.659  71.894  1.00 99.77  ?  322 LYS A C   1 
ATOM   1193 O O   . LYS A 1 341 ? -23.739 67.505  71.502  1.00 99.55  ?  322 LYS A O   1 
ATOM   1194 C CB  . LYS A 1 341 ? -21.699 69.763  71.332  1.00 88.81  ?  322 LYS A CB  1 
ATOM   1195 C CG  . LYS A 1 341 ? -22.051 70.962  70.472  1.00 98.93  ?  322 LYS A CG  1 
ATOM   1196 C CD  . LYS A 1 341 ? -20.818 71.563  69.762  1.00 104.66 ?  322 LYS A CD  1 
ATOM   1197 C CE  . LYS A 1 341 ? -21.223 72.340  68.491  1.00 110.14 ?  322 LYS A CE  1 
ATOM   1198 N NZ  . LYS A 1 341 ? -20.178 73.290  67.954  1.00 114.15 ?  322 LYS A NZ  1 
ATOM   1199 N N   . GLY A 1 342 ? -25.105 69.245  71.909  1.00 100.90 ?  323 GLY A N   1 
ATOM   1200 C CA  . GLY A 1 342 ? -26.281 68.450  71.578  1.00 101.21 ?  323 GLY A CA  1 
ATOM   1201 C C   . GLY A 1 342 ? -26.401 67.238  72.488  1.00 104.87 ?  323 GLY A C   1 
ATOM   1202 O O   . GLY A 1 342 ? -26.065 67.294  73.673  1.00 104.63 ?  323 GLY A O   1 
ATOM   1203 N N   . ASN A 1 343 ? -26.877 66.112  71.923  1.00 106.30 ?  324 ASN A N   1 
ATOM   1204 C CA  . ASN A 1 343 ? -26.919 64.837  72.644  1.00 102.27 ?  324 ASN A CA  1 
ATOM   1205 C C   . ASN A 1 343 ? -25.585 64.079  72.589  1.00 100.98 ?  324 ASN A C   1 
ATOM   1206 O O   . ASN A 1 343 ? -25.507 62.942  73.079  1.00 100.84 ?  324 ASN A O   1 
ATOM   1207 C CB  . ASN A 1 343 ? -28.060 63.932  72.131  1.00 110.94 ?  324 ASN A CB  1 
ATOM   1208 C CG  . ASN A 1 343 ? -28.019 63.676  70.593  1.00 125.81 ?  324 ASN A CG  1 
ATOM   1209 O OD1 . ASN A 1 343 ? -27.795 64.596  69.791  1.00 120.26 ?  324 ASN A OD1 1 
ATOM   1210 N ND2 . ASN A 1 343 ? -28.212 62.400  70.191  1.00 121.93 ?  324 ASN A ND2 1 
ATOM   1211 N N   . TYR A 1 344 ? -24.553 64.695  72.004  1.00 99.09  ?  325 TYR A N   1 
ATOM   1212 C CA  . TYR A 1 344 ? -23.192 64.162  71.945  1.00 99.71  ?  325 TYR A CA  1 
ATOM   1213 C C   . TYR A 1 344 ? -22.474 64.344  73.286  1.00 99.97  ?  325 TYR A C   1 
ATOM   1214 O O   . TYR A 1 344 ? -22.398 65.459  73.810  1.00 100.39 ?  325 TYR A O   1 
ATOM   1215 C CB  . TYR A 1 344 ? -22.445 64.897  70.836  1.00 96.98  ?  325 TYR A CB  1 
ATOM   1216 C CG  . TYR A 1 344 ? -22.862 64.558  69.412  1.00 108.05 ?  325 TYR A CG  1 
ATOM   1217 C CD1 . TYR A 1 344 ? -22.147 63.669  68.640  1.00 107.85 ?  325 TYR A CD1 1 
ATOM   1218 C CD2 . TYR A 1 344 ? -24.073 65.018  68.902  1.00 112.69 ?  325 TYR A CD2 1 
ATOM   1219 C CE1 . TYR A 1 344 ? -22.545 63.364  67.337  1.00 112.31 ?  325 TYR A CE1 1 
ATOM   1220 C CE2 . TYR A 1 344 ? -24.492 64.688  67.627  1.00 111.94 ?  325 TYR A CE2 1 
ATOM   1221 C CZ  . TYR A 1 344 ? -23.733 63.871  66.845  1.00 116.90 ?  325 TYR A CZ  1 
ATOM   1222 O OH  . TYR A 1 344 ? -24.181 63.573  65.570  1.00 116.35 ?  325 TYR A OH  1 
ATOM   1223 N N   . VAL A 1 345 ? -21.931 63.253  73.834  1.00 96.27  ?  326 VAL A N   1 
ATOM   1224 C CA  . VAL A 1 345 ? -21.264 63.259  75.139  1.00 88.15  ?  326 VAL A CA  1 
ATOM   1225 C C   . VAL A 1 345 ? -20.034 62.357  75.072  1.00 91.71  ?  326 VAL A C   1 
ATOM   1226 O O   . VAL A 1 345 ? -20.145 61.177  74.723  1.00 102.17 ?  326 VAL A O   1 
ATOM   1227 C CB  . VAL A 1 345 ? -22.234 62.794  76.250  1.00 87.78  ?  326 VAL A CB  1 
ATOM   1228 C CG1 . VAL A 1 345 ? -21.513 62.524  77.566  1.00 86.61  ?  326 VAL A CG1 1 
ATOM   1229 C CG2 . VAL A 1 345 ? -23.359 63.795  76.434  1.00 89.24  ?  326 VAL A CG2 1 
ATOM   1230 N N   . ALA A 1 346 ? -18.853 62.884  75.399  1.00 88.79  ?  327 ALA A N   1 
ATOM   1231 C CA  . ALA A 1 346 ? -17.636 62.077  75.332  1.00 89.78  ?  327 ALA A CA  1 
ATOM   1232 C C   . ALA A 1 346 ? -16.567 62.616  76.276  1.00 86.41  ?  327 ALA A C   1 
ATOM   1233 O O   . ALA A 1 346 ? -16.268 63.814  76.244  1.00 88.77  ?  327 ALA A O   1 
ATOM   1234 C CB  . ALA A 1 346 ? -17.088 62.042  73.898  1.00 83.98  ?  327 ALA A CB  1 
ATOM   1235 N N   . ASP A 1 347 ? -15.958 61.744  77.082  1.00 76.95  ?  328 ASP A N   1 
ATOM   1236 C CA  . ASP A 1 347 ? -14.909 62.215  77.977  1.00 76.48  ?  328 ASP A CA  1 
ATOM   1237 C C   . ASP A 1 347 ? -13.571 62.395  77.282  1.00 76.68  ?  328 ASP A C   1 
ATOM   1238 O O   . ASP A 1 347 ? -13.018 61.455  76.713  1.00 77.09  ?  328 ASP A O   1 
ATOM   1239 C CB  . ASP A 1 347 ? -14.707 61.311  79.183  1.00 81.87  ?  328 ASP A CB  1 
ATOM   1240 C CG  . ASP A 1 347 ? -15.864 61.343  80.131  1.00 90.01  ?  328 ASP A CG  1 
ATOM   1241 O OD1 . ASP A 1 347 ? -16.914 61.940  79.856  1.00 93.83  ?  328 ASP A OD1 1 
ATOM   1242 O OD2 . ASP A 1 347 ? -15.637 60.894  81.253  1.00 95.58  ?  328 ASP A OD2 1 
ATOM   1243 N N   . LEU A 1 348 ? -13.025 63.602  77.409  1.00 80.92  ?  329 LEU A N   1 
ATOM   1244 C CA  . LEU A 1 348 ? -11.646 63.919  77.081  1.00 73.01  ?  329 LEU A CA  1 
ATOM   1245 C C   . LEU A 1 348 ? -10.675 63.530  78.188  1.00 68.20  ?  329 LEU A C   1 
ATOM   1246 O O   . LEU A 1 348 ? -9.466  63.498  77.950  1.00 68.30  ?  329 LEU A O   1 
ATOM   1247 C CB  . LEU A 1 348 ? -11.517 65.418  76.824  1.00 81.61  ?  329 LEU A CB  1 
ATOM   1248 C CG  . LEU A 1 348 ? -11.924 65.981  75.469  1.00 83.65  ?  329 LEU A CG  1 
ATOM   1249 C CD1 . LEU A 1 348 ? -11.019 65.346  74.420  1.00 84.93  ?  329 LEU A CD1 1 
ATOM   1250 C CD2 . LEU A 1 348 ? -13.401 65.748  75.187  1.00 84.00  ?  329 LEU A CD2 1 
ATOM   1251 N N   . GLY A 1 349 ? -11.170 63.248  79.390  1.00 73.83  ?  330 GLY A N   1 
ATOM   1252 C CA  . GLY A 1 349 ? -10.317 62.899  80.508  1.00 71.10  ?  330 GLY A CA  1 
ATOM   1253 C C   . GLY A 1 349 ? -10.449 61.448  80.896  1.00 71.61  ?  330 GLY A C   1 
ATOM   1254 O O   . GLY A 1 349 ? -10.565 60.588  80.031  1.00 77.48  ?  330 GLY A O   1 
ATOM   1255 N N   . ALA A 1 350 ? -10.410 61.150  82.183  1.00 71.85  ?  331 ALA A N   1 
ATOM   1256 C CA  . ALA A 1 350 ? -10.773 59.820  82.637  1.00 73.73  ?  331 ALA A CA  1 
ATOM   1257 C C   . ALA A 1 350 ? -12.107 59.400  82.025  1.00 77.42  ?  331 ALA A C   1 
ATOM   1258 O O   . ALA A 1 350 ? -13.011 60.220  81.861  1.00 82.72  ?  331 ALA A O   1 
ATOM   1259 C CB  . ALA A 1 350 ? -10.857 59.806  84.163  1.00 70.94  ?  331 ALA A CB  1 
ATOM   1260 N N   . MET A 1 351 ? -12.209 58.120  81.643  1.00 79.26  ?  332 MET A N   1 
ATOM   1261 C CA  . MET A 1 351 ? -13.473 57.577  81.153  1.00 80.90  ?  332 MET A CA  1 
ATOM   1262 C C   . MET A 1 351 ? -13.784 56.198  81.701  1.00 72.25  ?  332 MET A C   1 
ATOM   1263 O O   . MET A 1 351 ? -14.901 55.719  81.488  1.00 75.91  ?  332 MET A O   1 
ATOM   1264 C CB  . MET A 1 351 ? -13.491 57.501  79.619  1.00 83.43  ?  332 MET A CB  1 
ATOM   1265 C CG  . MET A 1 351 ? -12.535 56.467  79.058  1.00 82.77  ?  332 MET A CG  1 
ATOM   1266 S SD  . MET A 1 351 ? -12.393 56.601  77.265  1.00 101.36 ?  332 MET A SD  1 
ATOM   1267 C CE  . MET A 1 351 ? -10.727 55.959  77.023  1.00 84.47  ?  332 MET A CE  1 
ATOM   1268 N N   . VAL A 1 352 ? -12.863 55.563  82.417  1.00 65.83  ?  333 VAL A N   1 
ATOM   1269 C CA  . VAL A 1 352 ? -12.997 54.183  82.858  1.00 69.08  ?  333 VAL A CA  1 
ATOM   1270 C C   . VAL A 1 352 ? -13.011 54.123  84.378  1.00 69.64  ?  333 VAL A C   1 
ATOM   1271 O O   . VAL A 1 352 ? -12.164 54.731  85.040  1.00 79.29  ?  333 VAL A O   1 
ATOM   1272 C CB  . VAL A 1 352 ? -11.853 53.295  82.311  1.00 71.29  ?  333 VAL A CB  1 
ATOM   1273 C CG1 . VAL A 1 352 ? -12.138 51.831  82.612  1.00 74.86  ?  333 VAL A CG1 1 
ATOM   1274 C CG2 . VAL A 1 352 ? -11.677 53.489  80.827  1.00 69.09  ?  333 VAL A CG2 1 
ATOM   1275 N N   . VAL A 1 353 ? -13.938 53.344  84.929  1.00 71.49  ?  334 VAL A N   1 
ATOM   1276 C CA  . VAL A 1 353 ? -13.931 52.960  86.338  1.00 69.75  ?  334 VAL A CA  1 
ATOM   1277 C C   . VAL A 1 353 ? -13.341 51.560  86.409  1.00 68.54  ?  334 VAL A C   1 
ATOM   1278 O O   . VAL A 1 353 ? -13.909 50.628  85.846  1.00 75.53  ?  334 VAL A O   1 
ATOM   1279 C CB  . VAL A 1 353 ? -15.350 53.003  86.931  1.00 64.61  ?  334 VAL A CB  1 
ATOM   1280 C CG1 . VAL A 1 353 ? -15.343 52.645  88.391  1.00 64.75  ?  334 VAL A CG1 1 
ATOM   1281 C CG2 . VAL A 1 353 ? -15.965 54.370  86.727  1.00 66.48  ?  334 VAL A CG2 1 
ATOM   1282 N N   . THR A 1 354 ? -12.222 51.388  87.104  1.00 69.65  ?  335 THR A N   1 
ATOM   1283 C CA  . THR A 1 354 ? -11.463 50.144  86.984  1.00 67.17  ?  335 THR A CA  1 
ATOM   1284 C C   . THR A 1 354 ? -11.994 49.049  87.871  1.00 75.34  ?  335 THR A C   1 
ATOM   1285 O O   . THR A 1 354 ? -11.201 48.277  88.428  1.00 83.09  ?  335 THR A O   1 
ATOM   1286 C CB  . THR A 1 354 ? -9.993  50.369  87.307  1.00 70.99  ?  335 THR A CB  1 
ATOM   1287 O OG1 . THR A 1 354 ? -9.827  50.566  88.714  1.00 72.28  ?  335 THR A OG1 1 
ATOM   1288 C CG2 . THR A 1 354 ? -9.574  51.620  86.626  1.00 77.15  ?  335 THR A CG2 1 
ATOM   1289 N N   . GLY A 1 355 ? -13.304 48.949  88.049  1.00 73.30  ?  336 GLY A N   1 
ATOM   1290 C CA  . GLY A 1 355 ? -13.793 47.747  88.699  1.00 80.56  ?  336 GLY A CA  1 
ATOM   1291 C C   . GLY A 1 355 ? -14.203 48.006  90.119  1.00 79.80  ?  336 GLY A C   1 
ATOM   1292 O O   . GLY A 1 355 ? -13.434 48.593  90.880  1.00 81.24  ?  336 GLY A O   1 
ATOM   1293 N N   . LEU A 1 356 ? -15.401 47.575  90.491  1.00 77.22  ?  337 LEU A N   1 
ATOM   1294 C CA  . LEU A 1 356 ? -16.031 48.053  91.712  1.00 75.37  ?  337 LEU A CA  1 
ATOM   1295 C C   . LEU A 1 356 ? -15.625 47.270  92.967  1.00 79.29  ?  337 LEU A C   1 
ATOM   1296 O O   . LEU A 1 356 ? -16.143 47.559  94.051  1.00 83.86  ?  337 LEU A O   1 
ATOM   1297 C CB  . LEU A 1 356 ? -17.552 48.034  91.542  1.00 68.84  ?  337 LEU A CB  1 
ATOM   1298 C CG  . LEU A 1 356 ? -18.085 48.665  90.257  1.00 72.63  ?  337 LEU A CG  1 
ATOM   1299 C CD1 . LEU A 1 356 ? -19.596 48.746  90.275  1.00 70.59  ?  337 LEU A CD1 1 
ATOM   1300 C CD2 . LEU A 1 356 ? -17.500 50.034  90.034  1.00 77.51  ?  337 LEU A CD2 1 
ATOM   1301 N N   . GLY A 1 357 ? -14.695 46.324  92.867  1.00 76.61  ?  338 GLY A N   1 
ATOM   1302 C CA  . GLY A 1 357 ? -14.340 45.500  94.006  1.00 76.78  ?  338 GLY A CA  1 
ATOM   1303 C C   . GLY A 1 357 ? -13.272 46.095  94.895  1.00 77.00  ?  338 GLY A C   1 
ATOM   1304 O O   . GLY A 1 357 ? -12.077 45.873  94.679  1.00 79.21  ?  338 GLY A O   1 
ATOM   1305 N N   . GLY A 1 358 ? -13.694 46.824  95.925  1.00 78.57  ?  339 GLY A N   1 
ATOM   1306 C CA  . GLY A 1 358 ? -12.793 47.626  96.725  1.00 82.22  ?  339 GLY A CA  1 
ATOM   1307 C C   . GLY A 1 358 ? -12.669 49.072  96.284  1.00 75.75  ?  339 GLY A C   1 
ATOM   1308 O O   . GLY A 1 358 ? -11.835 49.796  96.834  1.00 77.22  ?  339 GLY A O   1 
ATOM   1309 N N   . ASN A 1 359 ? -13.473 49.510  95.339  1.00 69.87  ?  340 ASN A N   1 
ATOM   1310 C CA  . ASN A 1 359 ? -13.360 50.811  94.711  1.00 73.28  ?  340 ASN A CA  1 
ATOM   1311 C C   . ASN A 1 359 ? -14.286 51.799  95.405  1.00 82.08  ?  340 ASN A C   1 
ATOM   1312 O O   . ASN A 1 359 ? -15.491 51.535  95.518  1.00 84.38  ?  340 ASN A O   1 
ATOM   1313 C CB  . ASN A 1 359 ? -13.712 50.726  93.232  1.00 74.04  ?  340 ASN A CB  1 
ATOM   1314 C CG  . ASN A 1 359 ? -13.480 52.031  92.483  1.00 75.96  ?  340 ASN A CG  1 
ATOM   1315 O OD1 . ASN A 1 359 ? -13.656 53.115  93.028  1.00 82.86  ?  340 ASN A OD1 1 
ATOM   1316 N ND2 . ASN A 1 359 ? -13.093 51.928  91.218  1.00 77.13  ?  340 ASN A ND2 1 
ATOM   1317 N N   . PRO A 1 360 ? -13.760 52.937  95.863  1.00 75.16  ?  341 PRO A N   1 
ATOM   1318 C CA  . PRO A 1 360 ? -14.628 53.964  96.448  1.00 79.32  ?  341 PRO A CA  1 
ATOM   1319 C C   . PRO A 1 360 ? -15.618 54.534  95.453  1.00 78.70  ?  341 PRO A C   1 
ATOM   1320 O O   . PRO A 1 360 ? -16.702 54.983  95.851  1.00 81.87  ?  341 PRO A O   1 
ATOM   1321 C CB  . PRO A 1 360 ? -13.639 55.037  96.921  1.00 80.00  ?  341 PRO A CB  1 
ATOM   1322 C CG  . PRO A 1 360 ? -12.374 54.758  96.187  1.00 76.30  ?  341 PRO A CG  1 
ATOM   1323 C CD  . PRO A 1 360 ? -12.340 53.304  95.913  1.00 73.73  ?  341 PRO A CD  1 
ATOM   1324 N N   . MET A 1 361 ? -15.282 54.547  94.167  1.00 71.71  ?  342 MET A N   1 
ATOM   1325 C CA  . MET A 1 361 ? -16.242 55.025  93.183  1.00 77.34  ?  342 MET A CA  1 
ATOM   1326 C C   . MET A 1 361 ? -17.534 54.209  93.200  1.00 81.17  ?  342 MET A C   1 
ATOM   1327 O O   . MET A 1 361 ? -18.561 54.678  92.697  1.00 81.57  ?  342 MET A O   1 
ATOM   1328 C CB  . MET A 1 361 ? -15.612 54.984  91.800  1.00 75.31  ?  342 MET A CB  1 
ATOM   1329 C CG  . MET A 1 361 ? -14.474 55.953  91.609  1.00 76.52  ?  342 MET A CG  1 
ATOM   1330 S SD  . MET A 1 361 ? -14.948 57.600  92.118  1.00 83.14  ?  342 MET A SD  1 
ATOM   1331 C CE  . MET A 1 361 ? -15.687 58.197  90.592  1.00 84.25  ?  342 MET A CE  1 
ATOM   1332 N N   . ALA A 1 362 ? -17.496 52.991  93.753  1.00 80.24  ?  343 ALA A N   1 
ATOM   1333 C CA  . ALA A 1 362 ? -18.715 52.212  93.955  1.00 81.25  ?  343 ALA A CA  1 
ATOM   1334 C C   . ALA A 1 362 ? -19.694 52.943  94.871  1.00 90.90  ?  343 ALA A C   1 
ATOM   1335 O O   . ALA A 1 362 ? -20.891 53.034  94.572  1.00 92.81  ?  343 ALA A O   1 
ATOM   1336 C CB  . ALA A 1 362 ? -18.362 50.844  94.535  1.00 82.30  ?  343 ALA A CB  1 
ATOM   1337 N N   . VAL A 1 363 ? -19.206 53.447  96.012  1.00 86.84  ?  344 VAL A N   1 
ATOM   1338 C CA  . VAL A 1 363 ? -20.049 54.259  96.887  1.00 81.23  ?  344 VAL A CA  1 
ATOM   1339 C C   . VAL A 1 363 ? -20.565 55.479  96.132  1.00 85.35  ?  344 VAL A C   1 
ATOM   1340 O O   . VAL A 1 363 ? -21.764 55.776  96.133  1.00 89.50  ?  344 VAL A O   1 
ATOM   1341 C CB  . VAL A 1 363 ? -19.273 54.665  98.151  1.00 80.42  ?  344 VAL A CB  1 
ATOM   1342 C CG1 . VAL A 1 363 ? -20.144 55.488  99.065  1.00 82.21  ?  344 VAL A CG1 1 
ATOM   1343 C CG2 . VAL A 1 363 ? -18.759 53.455  98.864  1.00 81.43  ?  344 VAL A CG2 1 
ATOM   1344 N N   . VAL A 1 364 ? -19.667 56.197  95.460  1.00 79.23  ?  345 VAL A N   1 
ATOM   1345 C CA  . VAL A 1 364 ? -20.095 57.357  94.701  1.00 82.35  ?  345 VAL A CA  1 
ATOM   1346 C C   . VAL A 1 364 ? -21.103 56.990  93.623  1.00 87.57  ?  345 VAL A C   1 
ATOM   1347 O O   . VAL A 1 364 ? -21.887 57.844  93.195  1.00 91.59  ?  345 VAL A O   1 
ATOM   1348 C CB  . VAL A 1 364 ? -18.862 58.056  94.110  1.00 83.47  ?  345 VAL A CB  1 
ATOM   1349 C CG1 . VAL A 1 364 ? -19.256 59.376  93.433  1.00 84.00  ?  345 VAL A CG1 1 
ATOM   1350 C CG2 . VAL A 1 364 ? -17.828 58.278  95.212  1.00 78.01  ?  345 VAL A CG2 1 
ATOM   1351 N N   . SER A 1 365 ? -21.135 55.723  93.197  1.00 93.19  ?  346 SER A N   1 
ATOM   1352 C CA  . SER A 1 365 ? -22.055 55.323  92.135  1.00 92.94  ?  346 SER A CA  1 
ATOM   1353 C C   . SER A 1 365 ? -23.492 55.229  92.633  1.00 94.66  ?  346 SER A C   1 
ATOM   1354 O O   . SER A 1 365 ? -24.420 55.626  91.920  1.00 96.96  ?  346 SER A O   1 
ATOM   1355 C CB  . SER A 1 365 ? -21.610 54.001  91.512  1.00 89.98  ?  346 SER A CB  1 
ATOM   1356 O OG  . SER A 1 365 ? -21.516 52.991  92.492  1.00 98.51  ?  346 SER A OG  1 
ATOM   1357 N N   . LYS A 1 366 ? -23.707 54.705  93.845  1.00 90.08  ?  347 LYS A N   1 
ATOM   1358 C CA  . LYS A 1 366 ? -25.059 54.747  94.377  1.00 88.98  ?  347 LYS A CA  1 
ATOM   1359 C C   . LYS A 1 366 ? -25.450 56.164  94.752  1.00 95.40  ?  347 LYS A C   1 
ATOM   1360 O O   . LYS A 1 366 ? -26.646 56.473  94.813  1.00 100.98 ?  347 LYS A O   1 
ATOM   1361 C CB  . LYS A 1 366 ? -25.212 53.868  95.606  1.00 93.29  ?  347 LYS A CB  1 
ATOM   1362 C CG  . LYS A 1 366 ? -24.937 52.394  95.440  1.00 96.96  ?  347 LYS A CG  1 
ATOM   1363 C CD  . LYS A 1 366 ? -25.330 51.703  96.751  1.00 103.52 ?  347 LYS A CD  1 
ATOM   1364 C CE  . LYS A 1 366 ? -25.001 50.229  96.765  1.00 106.13 ?  347 LYS A CE  1 
ATOM   1365 N NZ  . LYS A 1 366 ? -23.485 50.113  96.726  1.00 105.96 ?  347 LYS A NZ  1 
ATOM   1366 N N   . GLN A 1 367 ? -24.462 57.029  94.995  1.00 92.60  ?  348 GLN A N   1 
ATOM   1367 C CA  . GLN A 1 367 ? -24.727 58.381  95.473  1.00 93.98  ?  348 GLN A CA  1 
ATOM   1368 C C   . GLN A 1 367 ? -25.111 59.296  94.322  1.00 94.84  ?  348 GLN A C   1 
ATOM   1369 O O   . GLN A 1 367 ? -26.077 60.058  94.413  1.00 94.95  ?  348 GLN A O   1 
ATOM   1370 C CB  . GLN A 1 367 ? -23.506 58.914  96.226  1.00 90.29  ?  348 GLN A CB  1 
ATOM   1371 C CG  . GLN A 1 367 ? -23.387 58.395  97.664  1.00 88.88  ?  348 GLN A CG  1 
ATOM   1372 C CD  . GLN A 1 367 ? -22.149 58.910  98.384  1.00 86.42  ?  348 GLN A CD  1 
ATOM   1373 O OE1 . GLN A 1 367 ? -21.326 59.606  97.805  1.00 84.41  ?  348 GLN A OE1 1 
ATOM   1374 N NE2 . GLN A 1 367 ? -22.022 58.574  99.659  1.00 90.60  ?  348 GLN A NE2 1 
ATOM   1375 N N   . VAL A 1 368 ? -24.368 59.187  93.241  1.00 98.33  ?  349 VAL A N   1 
ATOM   1376 C CA  . VAL A 1 368 ? -24.714 59.999  92.055  1.00 99.04  ?  349 VAL A CA  1 
ATOM   1377 C C   . VAL A 1 368 ? -25.175 59.040  90.975  1.00 109.01 ?  349 VAL A C   1 
ATOM   1378 O O   . VAL A 1 368 ? -24.591 57.966  90.856  1.00 105.76 ?  349 VAL A O   1 
ATOM   1379 C CB  . VAL A 1 368 ? -23.506 60.788  91.571  1.00 92.75  ?  349 VAL A CB  1 
ATOM   1380 C CG1 . VAL A 1 368 ? -23.919 61.725  90.464  1.00 99.16  ?  349 VAL A CG1 1 
ATOM   1381 C CG2 . VAL A 1 368 ? -22.917 61.555  92.722  1.00 94.94  ?  349 VAL A CG2 1 
ATOM   1382 N N   . ASN A 1 369 ? -26.194 59.424  90.228  1.00 113.18 ?  350 ASN A N   1 
ATOM   1383 C CA  . ASN A 1 369 ? -26.674 58.501  89.183  1.00 115.99 ?  350 ASN A CA  1 
ATOM   1384 C C   . ASN A 1 369 ? -25.706 58.556  88.020  1.00 114.09 ?  350 ASN A C   1 
ATOM   1385 O O   . ASN A 1 369 ? -25.761 59.528  87.280  1.00 112.52 ?  350 ASN A O   1 
ATOM   1386 C CB  . ASN A 1 369 ? -28.019 58.925  88.615  1.00 126.17 ?  350 ASN A CB  1 
ATOM   1387 C CG  . ASN A 1 369 ? -28.214 58.397  87.214  1.00 129.51 ?  350 ASN A CG  1 
ATOM   1388 O OD1 . ASN A 1 369 ? -28.039 57.210  86.976  1.00 128.08 ?  350 ASN A OD1 1 
ATOM   1389 N ND2 . ASN A 1 369 ? -28.562 59.268  86.284  1.00 128.27 ?  350 ASN A ND2 1 
ATOM   1390 N N   . MET A 1 370 ? -24.837 57.561  87.912  1.00 109.55 ?  351 MET A N   1 
ATOM   1391 C CA  . MET A 1 370 ? -23.931 57.495  86.750  1.00 108.89 ?  351 MET A CA  1 
ATOM   1392 C C   . MET A 1 370 ? -24.406 56.309  85.931  1.00 112.52 ?  351 MET A C   1 
ATOM   1393 O O   . MET A 1 370 ? -24.568 55.251  86.520  1.00 111.02 ?  351 MET A O   1 
ATOM   1394 C CB  . MET A 1 370 ? -22.509 57.165  87.182  1.00 107.61 ?  351 MET A CB  1 
ATOM   1395 C CG  . MET A 1 370 ? -21.866 58.185  88.046  1.00 105.86 ?  351 MET A CG  1 
ATOM   1396 S SD  . MET A 1 370 ? -20.393 57.428  88.706  1.00 107.01 ?  351 MET A SD  1 
ATOM   1397 C CE  . MET A 1 370 ? -21.086 56.436  90.024  1.00 86.49  ?  351 MET A CE  1 
ATOM   1398 N N   . GLU A 1 371 ? -24.662 56.489  84.642  1.00 111.19 ?  352 GLU A N   1 
ATOM   1399 C CA  . GLU A 1 371 ? -25.053 55.306  83.850  1.00 109.91 ?  352 GLU A CA  1 
ATOM   1400 C C   . GLU A 1 371 ? -23.765 54.539  83.582  1.00 103.40 ?  352 GLU A C   1 
ATOM   1401 O O   . GLU A 1 371 ? -23.094 54.850  82.619  1.00 104.36 ?  352 GLU A O   1 
ATOM   1402 C CB  . GLU A 1 371 ? -25.754 55.718  82.561  1.00 114.24 ?  352 GLU A CB  1 
ATOM   1403 C CG  . GLU A 1 371 ? -25.586 54.694  81.454  1.00 123.14 ?  352 GLU A CG  1 
ATOM   1404 C CD  . GLU A 1 371 ? -26.759 53.765  81.191  1.00 130.89 ?  352 GLU A CD  1 
ATOM   1405 O OE1 . GLU A 1 371 ? -27.059 52.932  82.063  1.00 132.61 ?  352 GLU A OE1 1 
ATOM   1406 O OE2 . GLU A 1 371 ? -27.356 53.868  80.105  1.00 127.39 ?  352 GLU A OE2 1 
ATOM   1407 N N   . LEU A 1 372 ? -23.452 53.583  84.441  1.00 95.40  ?  353 LEU A N   1 
ATOM   1408 C CA  . LEU A 1 372 ? -22.200 52.811  84.348  1.00 92.92  ?  353 LEU A CA  1 
ATOM   1409 C C   . LEU A 1 372 ? -22.362 51.582  83.456  1.00 95.53  ?  353 LEU A C   1 
ATOM   1410 O O   . LEU A 1 372 ? -23.077 50.644  83.822  1.00 95.50  ?  353 LEU A O   1 
ATOM   1411 C CB  . LEU A 1 372 ? -21.804 52.334  85.736  1.00 93.51  ?  353 LEU A CB  1 
ATOM   1412 C CG  . LEU A 1 372 ? -21.198 53.185  86.823  1.00 96.18  ?  353 LEU A CG  1 
ATOM   1413 C CD1 . LEU A 1 372 ? -21.776 52.697  88.138  1.00 97.80  ?  353 LEU A CD1 1 
ATOM   1414 C CD2 . LEU A 1 372 ? -19.688 53.038  86.826  1.00 82.06  ?  353 LEU A CD2 1 
ATOM   1415 N N   . ALA A 1 373 ? -21.646 51.532  82.335  1.00 99.27  ?  354 ALA A N   1 
ATOM   1416 C CA  . ALA A 1 373 ? -21.815 50.480  81.338  1.00 89.76  ?  354 ALA A CA  1 
ATOM   1417 C C   . ALA A 1 373 ? -20.536 49.672  81.196  1.00 88.74  ?  354 ALA A C   1 
ATOM   1418 O O   . ALA A 1 373 ? -19.456 50.236  80.985  1.00 90.76  ?  354 ALA A O   1 
ATOM   1419 C CB  . ALA A 1 373 ? -22.210 51.076  79.992  1.00 92.82  ?  354 ALA A CB  1 
ATOM   1420 N N   . LYS A 1 374 ? -20.674 48.355  81.278  1.00 94.07  ?  355 LYS A N   1 
ATOM   1421 C CA  . LYS A 1 374 ? -19.535 47.452  81.300  1.00 91.67  ?  355 LYS A CA  1 
ATOM   1422 C C   . LYS A 1 374 ? -18.830 47.443  79.939  1.00 92.74  ?  355 LYS A C   1 
ATOM   1423 O O   . LYS A 1 374 ? -19.423 47.753  78.898  1.00 92.74  ?  355 LYS A O   1 
ATOM   1424 C CB  . LYS A 1 374 ? -20.040 46.073  81.718  1.00 91.36  ?  355 LYS A CB  1 
ATOM   1425 C CG  . LYS A 1 374 ? -19.112 44.872  81.652  1.00 107.46 ?  355 LYS A CG  1 
ATOM   1426 C CD  . LYS A 1 374 ? -19.715 43.771  82.567  1.00 117.21 ?  355 LYS A CD  1 
ATOM   1427 C CE  . LYS A 1 374 ? -19.136 42.338  82.380  1.00 123.04 ?  355 LYS A CE  1 
ATOM   1428 N NZ  . LYS A 1 374 ? -17.657 42.200  82.174  1.00 121.36 ?  355 LYS A NZ  1 
ATOM   1429 N N   . ILE A 1 375 ? -17.530 47.154  79.967  1.00 93.32  ?  356 ILE A N   1 
ATOM   1430 C CA  . ILE A 1 375 ? -16.670 47.172  78.783  1.00 95.58  ?  356 ILE A CA  1 
ATOM   1431 C C   . ILE A 1 375 ? -16.380 45.735  78.375  1.00 100.53 ?  356 ILE A C   1 
ATOM   1432 O O   . ILE A 1 375 ? -15.791 44.965  79.149  1.00 99.76  ?  356 ILE A O   1 
ATOM   1433 C CB  . ILE A 1 375 ? -15.355 47.924  79.036  1.00 94.19  ?  356 ILE A CB  1 
ATOM   1434 C CG1 . ILE A 1 375 ? -15.534 49.417  78.841  1.00 91.99  ?  356 ILE A CG1 1 
ATOM   1435 C CG2 . ILE A 1 375 ? -14.214 47.401  78.152  1.00 94.49  ?  356 ILE A CG2 1 
ATOM   1436 C CD1 . ILE A 1 375 ? -14.382 50.179  79.460  1.00 90.30  ?  356 ILE A CD1 1 
ATOM   1437 N N   . LYS A 1 376 ? -16.779 45.394  77.149  1.00 97.82  ?  357 LYS A N   1 
ATOM   1438 C CA  . LYS A 1 376 ? -16.531 44.085  76.564  1.00 100.59 ?  357 LYS A CA  1 
ATOM   1439 C C   . LYS A 1 376 ? -15.070 44.012  76.125  1.00 101.65 ?  357 LYS A C   1 
ATOM   1440 O O   . LYS A 1 376 ? -14.631 44.814  75.294  1.00 100.73 ?  357 LYS A O   1 
ATOM   1441 C CB  . LYS A 1 376 ? -17.477 43.888  75.380  1.00 107.28 ?  357 LYS A CB  1 
ATOM   1442 C CG  . LYS A 1 376 ? -18.947 43.678  75.765  1.00 106.55 ?  357 LYS A CG  1 
ATOM   1443 C CD  . LYS A 1 376 ? -19.877 43.682  74.541  1.00 107.99 ?  357 LYS A CD  1 
ATOM   1444 C CE  . LYS A 1 376 ? -21.243 44.298  74.877  1.00 111.40 ?  357 LYS A CE  1 
ATOM   1445 N NZ  . LYS A 1 376 ? -22.371 43.802  74.022  1.00 109.22 ?  357 LYS A NZ  1 
ATOM   1446 N N   . GLN A 1 377 ? -14.312 43.060  76.668  1.00 101.24 ?  358 GLN A N   1 
ATOM   1447 C CA  . GLN A 1 377 ? -12.864 43.102  76.482  1.00 106.12 ?  358 GLN A CA  1 
ATOM   1448 C C   . GLN A 1 377 ? -12.416 42.614  75.096  1.00 108.43 ?  358 GLN A C   1 
ATOM   1449 O O   . GLN A 1 377 ? -11.224 42.723  74.770  1.00 108.26 ?  358 GLN A O   1 
ATOM   1450 C CB  . GLN A 1 377 ? -12.171 42.304  77.604  1.00 109.81 ?  358 GLN A CB  1 
ATOM   1451 C CG  . GLN A 1 377 ? -12.542 42.704  79.090  1.00 111.83 ?  358 GLN A CG  1 
ATOM   1452 C CD  . GLN A 1 377 ? -12.014 44.096  79.583  1.00 117.61 ?  358 GLN A CD  1 
ATOM   1453 O OE1 . GLN A 1 377 ? -11.466 44.896  78.808  1.00 108.69 ?  358 GLN A OE1 1 
ATOM   1454 N NE2 . GLN A 1 377 ? -12.173 44.360  80.899  1.00 105.83 ?  358 GLN A NE2 1 
ATOM   1455 N N   . LYS A 1 378 ? -13.342 42.094  74.278  1.00 111.30 ?  359 LYS A N   1 
ATOM   1456 C CA  . LYS A 1 378 ? -13.067 41.721  72.888  1.00 110.69 ?  359 LYS A CA  1 
ATOM   1457 C C   . LYS A 1 378 ? -12.495 42.893  72.096  1.00 101.07 ?  359 LYS A C   1 
ATOM   1458 O O   . LYS A 1 378 ? -13.197 43.876  71.842  1.00 97.45  ?  359 LYS A O   1 
ATOM   1459 C CB  . LYS A 1 378 ? -14.352 41.244  72.203  1.00 111.59 ?  359 LYS A CB  1 
ATOM   1460 C CG  . LYS A 1 378 ? -14.128 40.917  70.711  1.00 111.06 ?  359 LYS A CG  1 
ATOM   1461 C CD  . LYS A 1 378 ? -15.382 40.444  69.956  1.00 112.54 ?  359 LYS A CD  1 
ATOM   1462 C CE  . LYS A 1 378 ? -15.029 40.118  68.486  1.00 114.70 ?  359 LYS A CE  1 
ATOM   1463 N NZ  . LYS A 1 378 ? -16.231 39.770  67.660  1.00 109.30 ?  359 LYS A NZ  1 
ATOM   1464 N N   . CYS A 1 379 ? -11.247 42.773  71.651  1.00 99.73  ?  360 CYS A N   1 
ATOM   1465 C CA  . CYS A 1 379 ? -10.622 43.825  70.850  1.00 96.10  ?  360 CYS A CA  1 
ATOM   1466 C C   . CYS A 1 379 ? -10.052 43.255  69.556  1.00 93.15  ?  360 CYS A C   1 
ATOM   1467 O O   . CYS A 1 379 ? -8.968  42.640  69.563  1.00 97.37  ?  360 CYS A O   1 
ATOM   1468 C CB  . CYS A 1 379 ? -9.535  44.548  71.633  1.00 95.48  ?  360 CYS A CB  1 
ATOM   1469 S SG  . CYS A 1 379 ? -9.098  46.101  70.823  1.00 90.71  ?  360 CYS A SG  1 
ATOM   1470 N N   . PRO A 1 380 ? -10.750 43.436  68.434  1.00 85.26  ?  361 PRO A N   1 
ATOM   1471 C CA  . PRO A 1 380 ? -10.257 42.974  67.130  1.00 86.40  ?  361 PRO A CA  1 
ATOM   1472 C C   . PRO A 1 380 ? -9.236  43.926  66.527  1.00 85.03  ?  361 PRO A C   1 
ATOM   1473 O O   . PRO A 1 380 ? -9.559  45.066  66.198  1.00 89.32  ?  361 PRO A O   1 
ATOM   1474 C CB  . PRO A 1 380 ? -11.528 42.919  66.276  1.00 88.69  ?  361 PRO A CB  1 
ATOM   1475 C CG  . PRO A 1 380 ? -12.463 43.831  66.927  1.00 91.65  ?  361 PRO A CG  1 
ATOM   1476 C CD  . PRO A 1 380 ? -12.192 43.706  68.400  1.00 92.70  ?  361 PRO A CD  1 
ATOM   1477 N N   . LEU A 1 381 ? -8.026  43.426  66.305  1.00 87.83  ?  362 LEU A N   1 
ATOM   1478 C CA  . LEU A 1 381 ? -6.956  44.174  65.651  1.00 85.64  ?  362 LEU A CA  1 
ATOM   1479 C C   . LEU A 1 381 ? -7.116  44.213  64.132  1.00 87.25  ?  362 LEU A C   1 
ATOM   1480 O O   . LEU A 1 381 ? -7.761  43.354  63.525  1.00 92.99  ?  362 LEU A O   1 
ATOM   1481 C CB  . LEU A 1 381 ? -5.621  43.549  66.044  1.00 85.74  ?  362 LEU A CB  1 
ATOM   1482 C CG  . LEU A 1 381 ? -5.060  44.072  67.362  1.00 86.26  ?  362 LEU A CG  1 
ATOM   1483 C CD1 . LEU A 1 381 ? -5.980  43.879  68.547  1.00 92.02  ?  362 LEU A CD1 1 
ATOM   1484 C CD2 . LEU A 1 381 ? -3.832  43.213  67.610  1.00 88.61  ?  362 LEU A CD2 1 
ATOM   1485 N N   . TYR A 1 382 ? -6.534  45.240  63.522  1.00 83.97  ?  363 TYR A N   1 
ATOM   1486 C CA  . TYR A 1 382 ? -6.623  45.453  62.084  1.00 86.49  ?  363 TYR A CA  1 
ATOM   1487 C C   . TYR A 1 382 ? -5.344  46.120  61.617  1.00 89.60  ?  363 TYR A C   1 
ATOM   1488 O O   . TYR A 1 382 ? -4.952  47.148  62.172  1.00 90.52  ?  363 TYR A O   1 
ATOM   1489 C CB  . TYR A 1 382 ? -7.798  46.353  61.705  1.00 87.92  ?  363 TYR A CB  1 
ATOM   1490 C CG  . TYR A 1 382 ? -9.189  45.798  61.903  1.00 93.27  ?  363 TYR A CG  1 
ATOM   1491 C CD1 . TYR A 1 382 ? -9.761  45.723  63.161  1.00 94.27  ?  363 TYR A CD1 1 
ATOM   1492 C CD2 . TYR A 1 382 ? -9.947  45.380  60.822  1.00 96.57  ?  363 TYR A CD2 1 
ATOM   1493 C CE1 . TYR A 1 382 ? -11.048 45.219  63.345  1.00 95.97  ?  363 TYR A CE1 1 
ATOM   1494 C CE2 . TYR A 1 382 ? -11.232 44.877  60.992  1.00 97.30  ?  363 TYR A CE2 1 
ATOM   1495 C CZ  . TYR A 1 382 ? -11.778 44.802  62.256  1.00 97.89  ?  363 TYR A CZ  1 
ATOM   1496 O OH  . TYR A 1 382 ? -13.053 44.310  62.438  1.00 97.86  ?  363 TYR A OH  1 
ATOM   1497 N N   . GLU A 1 383 ? -4.720  45.573  60.582  1.00 94.23  ?  364 GLU A N   1 
ATOM   1498 C CA  . GLU A 1 383 ? -3.437  46.095  60.140  1.00 89.86  ?  364 GLU A CA  1 
ATOM   1499 C C   . GLU A 1 383 ? -3.624  47.344  59.294  1.00 91.59  ?  364 GLU A C   1 
ATOM   1500 O O   . GLU A 1 383 ? -4.745  47.773  59.000  1.00 94.90  ?  364 GLU A O   1 
ATOM   1501 C CB  . GLU A 1 383 ? -2.681  45.027  59.379  1.00 95.03  ?  364 GLU A CB  1 
ATOM   1502 C CG  . GLU A 1 383 ? -2.821  43.699  60.066  1.00 104.68 ?  364 GLU A CG  1 
ATOM   1503 C CD  . GLU A 1 383 ? -1.786  42.708  59.616  1.00 112.14 ?  364 GLU A CD  1 
ATOM   1504 O OE1 . GLU A 1 383 ? -2.163  41.531  59.381  1.00 108.89 ?  364 GLU A OE1 1 
ATOM   1505 O OE2 . GLU A 1 383 ? -0.604  43.120  59.507  1.00 112.02 ?  364 GLU A OE2 1 
ATOM   1506 N N   . ALA A 1 384 ? -2.497  47.944  58.905  1.00 90.64  ?  365 ALA A N   1 
ATOM   1507 C CA  . ALA A 1 384 ? -2.555  49.153  58.091  1.00 93.09  ?  365 ALA A CA  1 
ATOM   1508 C C   . ALA A 1 384 ? -3.131  48.886  56.704  1.00 98.47  ?  365 ALA A C   1 
ATOM   1509 O O   . ALA A 1 384 ? -3.622  49.823  56.062  1.00 96.11  ?  365 ALA A O   1 
ATOM   1510 C CB  . ALA A 1 384 ? -1.165  49.783  57.983  1.00 90.64  ?  365 ALA A CB  1 
ATOM   1511 N N   . ASN A 1 385 ? -3.070  47.633  56.225  1.00 103.28 ?  366 ASN A N   1 
ATOM   1512 C CA  . ASN A 1 385 ? -3.739  47.275  54.975  1.00 96.71  ?  366 ASN A CA  1 
ATOM   1513 C C   . ASN A 1 385 ? -5.231  47.577  55.055  1.00 100.71 ?  366 ASN A C   1 
ATOM   1514 O O   . ASN A 1 385 ? -5.801  48.169  54.132  1.00 105.84 ?  366 ASN A O   1 
ATOM   1515 C CB  . ASN A 1 385 ? -3.471  45.801  54.632  1.00 87.30  ?  366 ASN A CB  1 
ATOM   1516 C CG  . ASN A 1 385 ? -4.317  44.801  55.461  1.00 105.87 ?  366 ASN A CG  1 
ATOM   1517 O OD1 . ASN A 1 385 ? -4.874  45.136  56.512  1.00 103.40 ?  366 ASN A OD1 1 
ATOM   1518 N ND2 . ASN A 1 385 ? -4.384  43.550  54.986  1.00 109.24 ?  366 ASN A ND2 1 
ATOM   1519 N N   . GLY A 1 386 ? -5.861  47.243  56.181  1.00 96.02  ?  367 GLY A N   1 
ATOM   1520 C CA  . GLY A 1 386 ? -7.267  47.513  56.392  1.00 96.60  ?  367 GLY A CA  1 
ATOM   1521 C C   . GLY A 1 386 ? -8.030  46.275  56.808  1.00 104.24 ?  367 GLY A C   1 
ATOM   1522 O O   . GLY A 1 386 ? -9.225  46.339  57.123  1.00 104.42 ?  367 GLY A O   1 
ATOM   1523 N N   . GLN A 1 387 ? -7.346  45.134  56.814  1.00 103.35 ?  368 GLN A N   1 
ATOM   1524 C CA  . GLN A 1 387 ? -7.994  43.851  57.015  1.00 101.82 ?  368 GLN A CA  1 
ATOM   1525 C C   . GLN A 1 387 ? -7.594  43.256  58.351  1.00 97.21  ?  368 GLN A C   1 
ATOM   1526 O O   . GLN A 1 387 ? -6.476  43.453  58.838  1.00 95.84  ?  368 GLN A O   1 
ATOM   1527 C CB  . GLN A 1 387 ? -7.666  42.866  55.885  1.00 109.26 ?  368 GLN A CB  1 
ATOM   1528 C CG  . GLN A 1 387 ? -8.690  42.872  54.740  1.00 115.05 ?  368 GLN A CG  1 
ATOM   1529 C CD  . GLN A 1 387 ? -8.173  42.202  53.477  1.00 125.02 ?  368 GLN A CD  1 
ATOM   1530 O OE1 . GLN A 1 387 ? -7.035  42.431  53.053  1.00 125.81 ?  368 GLN A OE1 1 
ATOM   1531 N NE2 . GLN A 1 387 ? -9.004  41.354  52.877  1.00 123.02 ?  368 GLN A NE2 1 
ATOM   1532 N N   . ALA A 1 388 ? -8.537  42.530  58.921  1.00 94.88  ?  369 ALA A N   1 
ATOM   1533 C CA  . ALA A 1 388 ? -8.415  41.971  60.274  1.00 93.22  ?  369 ALA A CA  1 
ATOM   1534 C C   . ALA A 1 388 ? -7.247  41.012  60.409  1.00 95.98  ?  369 ALA A C   1 
ATOM   1535 O O   . ALA A 1 388 ? -6.908  40.335  59.467  1.00 98.64  ?  369 ALA A O   1 
ATOM   1536 C CB  . ALA A 1 388 ? -9.699  41.288  60.623  1.00 93.04  ?  369 ALA A CB  1 
ATOM   1537 N N   . VAL A 1 389 ? -6.678  40.966  61.598  1.00 94.68  ?  370 VAL A N   1 
ATOM   1538 C CA  . VAL A 1 389 ? -5.600  39.988  61.844  1.00 95.67  ?  370 VAL A CA  1 
ATOM   1539 C C   . VAL A 1 389 ? -6.322  38.683  62.128  1.00 102.59 ?  370 VAL A C   1 
ATOM   1540 O O   . VAL A 1 389 ? -7.305  38.707  62.854  1.00 101.98 ?  370 VAL A O   1 
ATOM   1541 C CB  . VAL A 1 389 ? -4.735  40.412  63.033  1.00 94.90  ?  370 VAL A CB  1 
ATOM   1542 C CG1 . VAL A 1 389 ? -4.048  39.222  63.656  1.00 101.10 ?  370 VAL A CG1 1 
ATOM   1543 C CG2 . VAL A 1 389 ? -3.717  41.447  62.620  1.00 91.09  ?  370 VAL A CG2 1 
ATOM   1544 N N   . PRO A 1 390 ? -5.880  37.556  61.556  1.00 101.45 ?  371 PRO A N   1 
ATOM   1545 C CA  . PRO A 1 390 ? -6.548  36.295  61.751  1.00 98.68  ?  371 PRO A CA  1 
ATOM   1546 C C   . PRO A 1 390 ? -6.323  35.810  63.176  1.00 102.32 ?  371 PRO A C   1 
ATOM   1547 O O   . PRO A 1 390 ? -5.248  35.982  63.656  1.00 102.57 ?  371 PRO A O   1 
ATOM   1548 C CB  . PRO A 1 390 ? -5.736  35.360  60.866  1.00 103.70 ?  371 PRO A CB  1 
ATOM   1549 C CG  . PRO A 1 390 ? -5.065  36.266  59.887  1.00 100.37 ?  371 PRO A CG  1 
ATOM   1550 C CD  . PRO A 1 390 ? -4.714  37.470  60.715  1.00 99.19  ?  371 PRO A CD  1 
ATOM   1551 N N   . LYS A 1 391 ? -7.317  35.125  63.734  1.00 98.80  ?  372 LYS A N   1 
ATOM   1552 C CA  . LYS A 1 391 ? -7.300  34.581  65.112  1.00 104.89 ?  372 LYS A CA  1 
ATOM   1553 C C   . LYS A 1 391 ? -5.966  33.908  65.423  1.00 108.84 ?  372 LYS A C   1 
ATOM   1554 O O   . LYS A 1 391 ? -5.409  34.226  66.448  1.00 109.56 ?  372 LYS A O   1 
ATOM   1555 C CB  . LYS A 1 391 ? -8.429  33.568  65.274  1.00 103.18 ?  372 LYS A CB  1 
ATOM   1556 C CG  . LYS A 1 391 ? -8.944  33.387  66.690  1.00 107.31 ?  372 LYS A CG  1 
ATOM   1557 C CD  . LYS A 1 391 ? -10.446 33.502  66.792  1.00 109.68 ?  372 LYS A CD  1 
ATOM   1558 C CE  . LYS A 1 391 ? -11.051 32.560  67.811  1.00 116.96 ?  372 LYS A CE  1 
ATOM   1559 N NZ  . LYS A 1 391 ? -11.845 33.282  68.832  1.00 122.14 ?  372 LYS A NZ  1 
ATOM   1560 N N   . GLU A 1 392 ? -5.492  33.017  64.559  1.00 111.74 ?  373 GLU A N   1 
ATOM   1561 C CA  . GLU A 1 392 ? -4.212  32.298  64.757  1.00 113.77 ?  373 GLU A CA  1 
ATOM   1562 C C   . GLU A 1 392 ? -3.105  33.282  65.126  1.00 108.82 ?  373 GLU A C   1 
ATOM   1563 O O   . GLU A 1 392 ? -2.465  33.055  66.134  1.00 102.29 ?  373 GLU A O   1 
ATOM   1564 C CB  . GLU A 1 392 ? -3.845  31.537  63.482  1.00 125.25 ?  373 GLU A CB  1 
ATOM   1565 C CG  . GLU A 1 392 ? -2.353  31.286  63.322  1.00 129.81 ?  373 GLU A CG  1 
ATOM   1566 C CD  . GLU A 1 392 ? -1.664  31.917  62.120  1.00 128.81 ?  373 GLU A CD  1 
ATOM   1567 O OE1 . GLU A 1 392 ? -2.306  32.700  61.408  1.00 131.72 ?  373 GLU A OE1 1 
ATOM   1568 O OE2 . GLU A 1 392 ? -0.479  31.627  61.906  1.00 136.75 ?  373 GLU A OE2 1 
ATOM   1569 N N   . LYS A 1 393 ? -2.932  34.348  64.352  1.00 104.68 ?  374 LYS A N   1 
ATOM   1570 C CA  . LYS A 1 393 ? -1.837  35.310  64.627  1.00 105.41 ?  374 LYS A CA  1 
ATOM   1571 C C   . LYS A 1 393 ? -2.107  36.003  65.954  1.00 103.44 ?  374 LYS A C   1 
ATOM   1572 O O   . LYS A 1 393 ? -1.246  35.970  66.832  1.00 98.53  ?  374 LYS A O   1 
ATOM   1573 C CB  . LYS A 1 393 ? -1.796  36.391  63.550  1.00 103.99 ?  374 LYS A CB  1 
ATOM   1574 C CG  . LYS A 1 393 ? -0.653  36.298  62.555  1.00 108.01 ?  374 LYS A CG  1 
ATOM   1575 C CD  . LYS A 1 393 ? 0.689   36.044  63.177  1.00 108.63 ?  374 LYS A CD  1 
ATOM   1576 C CE  . LYS A 1 393 ? 1.838   36.377  62.252  1.00 109.72 ?  374 LYS A CE  1 
ATOM   1577 N NZ  . LYS A 1 393 ? 3.112   36.567  62.986  1.00 117.15 ?  374 LYS A NZ  1 
ATOM   1578 N N   . ASP A 1 394 ? -3.297  36.576  66.073  1.00 101.57 ?  375 ASP A N   1 
ATOM   1579 C CA  . ASP A 1 394 ? -3.723  37.332  67.270  1.00 101.37 ?  375 ASP A CA  1 
ATOM   1580 C C   . ASP A 1 394 ? -3.411  36.556  68.539  1.00 96.97  ?  375 ASP A C   1 
ATOM   1581 O O   . ASP A 1 394 ? -2.813  37.122  69.409  1.00 101.03 ?  375 ASP A O   1 
ATOM   1582 C CB  . ASP A 1 394 ? -5.203  37.666  67.194  1.00 101.91 ?  375 ASP A CB  1 
ATOM   1583 C CG  . ASP A 1 394 ? -5.513  38.951  67.914  1.00 112.14 ?  375 ASP A CG  1 
ATOM   1584 O OD1 . ASP A 1 394 ? -4.577  39.543  68.438  1.00 110.93 ?  375 ASP A OD1 1 
ATOM   1585 O OD2 . ASP A 1 394 ? -6.680  39.334  67.945  1.00 118.33 ?  375 ASP A OD2 1 
ATOM   1586 N N   . GLU A 1 395 ? -3.789  35.295  68.622  1.00 94.98  ?  376 GLU A N   1 
ATOM   1587 C CA  . GLU A 1 395 ? -3.479  34.565  69.864  1.00 97.18  ?  376 GLU A CA  1 
ATOM   1588 C C   . GLU A 1 395 ? -1.974  34.348  69.986  1.00 94.04  ?  376 GLU A C   1 
ATOM   1589 O O   . GLU A 1 395 ? -1.523  34.391  71.112  1.00 90.11  ?  376 GLU A O   1 
ATOM   1590 C CB  . GLU A 1 395 ? -4.348  33.320  69.993  1.00 99.62  ?  376 GLU A CB  1 
ATOM   1591 C CG  . GLU A 1 395 ? -5.776  33.581  69.570  1.00 110.60 ?  376 GLU A CG  1 
ATOM   1592 C CD  . GLU A 1 395 ? -6.892  32.854  70.293  1.00 118.23 ?  376 GLU A CD  1 
ATOM   1593 O OE1 . GLU A 1 395 ? -6.659  31.740  70.775  1.00 115.29 ?  376 GLU A OE1 1 
ATOM   1594 O OE2 . GLU A 1 395 ? -7.998  33.408  70.349  1.00 120.51 ?  376 GLU A OE2 1 
ATOM   1595 N N   . MET A 1 396 ? -1.249  34.064  68.900  1.00 97.28  ?  377 MET A N   1 
ATOM   1596 C CA  . MET A 1 396 ? 0.201   33.929  69.033  1.00 100.51 ?  377 MET A CA  1 
ATOM   1597 C C   . MET A 1 396 ? 0.799   35.150  69.710  1.00 95.30  ?  377 MET A C   1 
ATOM   1598 O O   . MET A 1 396 ? 1.456   35.049  70.755  1.00 90.55  ?  377 MET A O   1 
ATOM   1599 C CB  . MET A 1 396 ? 0.914   33.741  67.686  1.00 102.13 ?  377 MET A CB  1 
ATOM   1600 C CG  . MET A 1 396 ? 2.430   33.794  67.991  1.00 112.85 ?  377 MET A CG  1 
ATOM   1601 S SD  . MET A 1 396 ? 3.781   33.667  66.812  1.00 143.90 ?  377 MET A SD  1 
ATOM   1602 C CE  . MET A 1 396 ? 5.187   33.878  67.945  1.00 114.03 ?  377 MET A CE  1 
ATOM   1603 N N   . VAL A 1 397 ? 0.575   36.318  69.107  1.00 93.16  ?  378 VAL A N   1 
ATOM   1604 C CA  . VAL A 1 397 ? 1.321   37.504  69.483  1.00 88.89  ?  378 VAL A CA  1 
ATOM   1605 C C   . VAL A 1 397 ? 0.945   37.952  70.885  1.00 87.17  ?  378 VAL A C   1 
ATOM   1606 O O   . VAL A 1 397 ? 1.821   38.236  71.713  1.00 83.06  ?  378 VAL A O   1 
ATOM   1607 C CB  . VAL A 1 397 ? 1.091   38.598  68.443  1.00 86.54  ?  378 VAL A CB  1 
ATOM   1608 C CG1 . VAL A 1 397 ? 2.060   39.699  68.670  1.00 87.87  ?  378 VAL A CG1 1 
ATOM   1609 C CG2 . VAL A 1 397 ? 1.298   38.015  67.079  1.00 93.69  ?  378 VAL A CG2 1 
ATOM   1610 N N   . GLU A 1 398 ? -0.353  37.972  71.193  1.00 86.12  ?  379 GLU A N   1 
ATOM   1611 C CA  . GLU A 1 398 ? -0.763  38.294  72.550  1.00 85.12  ?  379 GLU A CA  1 
ATOM   1612 C C   . GLU A 1 398 ? -0.019  37.431  73.562  1.00 82.77  ?  379 GLU A C   1 
ATOM   1613 O O   . GLU A 1 398 ? 0.554   37.950  74.525  1.00 83.66  ?  379 GLU A O   1 
ATOM   1614 C CB  . GLU A 1 398 ? -2.277  38.156  72.709  1.00 87.31  ?  379 GLU A CB  1 
ATOM   1615 C CG  . GLU A 1 398 ? -2.736  38.454  74.138  1.00 92.02  ?  379 GLU A CG  1 
ATOM   1616 C CD  . GLU A 1 398 ? -4.087  39.172  74.237  1.00 100.83 ?  379 GLU A CD  1 
ATOM   1617 O OE1 . GLU A 1 398 ? -4.585  39.676  73.195  1.00 101.53 ?  379 GLU A OE1 1 
ATOM   1618 O OE2 . GLU A 1 398 ? -4.631  39.242  75.376  1.00 101.33 ?  379 GLU A OE2 1 
ATOM   1619 N N   . GLN A 1 399 ? 0.039   36.115  73.338  1.00 88.66  ?  380 GLN A N   1 
ATOM   1620 C CA  . GLN A 1 399 ? 0.709   35.265  74.323  1.00 89.02  ?  380 GLN A CA  1 
ATOM   1621 C C   . GLN A 1 399 ? 2.215   35.493  74.321  1.00 84.67  ?  380 GLN A C   1 
ATOM   1622 O O   . GLN A 1 399 ? 2.877   35.307  75.349  1.00 82.41  ?  380 GLN A O   1 
ATOM   1623 C CB  . GLN A 1 399 ? 0.400   33.785  74.084  1.00 95.14  ?  380 GLN A CB  1 
ATOM   1624 C CG  . GLN A 1 399 ? 1.064   32.850  75.135  1.00 111.82 ?  380 GLN A CG  1 
ATOM   1625 C CD  . GLN A 1 399 ? 1.429   31.445  74.608  1.00 114.82 ?  380 GLN A CD  1 
ATOM   1626 O OE1 . GLN A 1 399 ? 2.612   31.111  74.438  1.00 109.57 ?  380 GLN A OE1 1 
ATOM   1627 N NE2 . GLN A 1 399 ? 0.413   30.612  74.391  1.00 116.47 ?  380 GLN A NE2 1 
ATOM   1628 N N   . GLU A 1 400 ? 2.778   35.914  73.195  1.00 83.06  ?  381 GLU A N   1 
ATOM   1629 C CA  . GLU A 1 400 ? 4.196   36.231  73.218  1.00 85.85  ?  381 GLU A CA  1 
ATOM   1630 C C   . GLU A 1 400 ? 4.430   37.520  73.995  1.00 84.06  ?  381 GLU A C   1 
ATOM   1631 O O   . GLU A 1 400 ? 5.361   37.609  74.812  1.00 77.47  ?  381 GLU A O   1 
ATOM   1632 C CB  . GLU A 1 400 ? 4.736   36.307  71.789  1.00 81.28  ?  381 GLU A CB  1 
ATOM   1633 C CG  . GLU A 1 400 ? 6.230   35.988  71.678  1.00 86.69  ?  381 GLU A CG  1 
ATOM   1634 C CD  . GLU A 1 400 ? 6.635   34.640  72.303  1.00 95.63  ?  381 GLU A CD  1 
ATOM   1635 O OE1 . GLU A 1 400 ? 5.849   33.659  72.265  1.00 100.23 ?  381 GLU A OE1 1 
ATOM   1636 O OE2 . GLU A 1 400 ? 7.760   34.569  72.845  1.00 93.96  ?  381 GLU A OE2 1 
ATOM   1637 N N   . PHE A 1 401 ? 3.547   38.502  73.792  1.00 80.65  ?  382 PHE A N   1 
ATOM   1638 C CA  . PHE A 1 401 ? 3.566   39.732  74.573  1.00 76.05  ?  382 PHE A CA  1 
ATOM   1639 C C   . PHE A 1 401 ? 3.531   39.437  76.070  1.00 78.52  ?  382 PHE A C   1 
ATOM   1640 O O   . PHE A 1 401 ? 4.423   39.856  76.819  1.00 77.42  ?  382 PHE A O   1 
ATOM   1641 C CB  . PHE A 1 401 ? 2.389   40.615  74.159  1.00 78.65  ?  382 PHE A CB  1 
ATOM   1642 C CG  . PHE A 1 401 ? 2.134   41.764  75.095  1.00 84.21  ?  382 PHE A CG  1 
ATOM   1643 C CD1 . PHE A 1 401 ? 3.031   42.810  75.186  1.00 79.18  ?  382 PHE A CD1 1 
ATOM   1644 C CD2 . PHE A 1 401 ? 1.006   41.784  75.898  1.00 84.91  ?  382 PHE A CD2 1 
ATOM   1645 C CE1 . PHE A 1 401 ? 2.805   43.835  76.036  1.00 75.66  ?  382 PHE A CE1 1 
ATOM   1646 C CE2 . PHE A 1 401 ? 0.785   42.810  76.754  1.00 79.33  ?  382 PHE A CE2 1 
ATOM   1647 C CZ  . PHE A 1 401 ? 1.681   43.835  76.826  1.00 77.57  ?  382 PHE A CZ  1 
ATOM   1648 N N   . ASN A 1 402 ? 2.513   38.690  76.522  1.00 79.18  ?  383 ASN A N   1 
ATOM   1649 C CA  . ASN A 1 402 ? 2.421   38.353  77.943  1.00 76.54  ?  383 ASN A CA  1 
ATOM   1650 C C   . ASN A 1 402 ? 3.660   37.611  78.414  1.00 79.00  ?  383 ASN A C   1 
ATOM   1651 O O   . ASN A 1 402 ? 4.116   37.802  79.550  1.00 74.85  ?  383 ASN A O   1 
ATOM   1652 C CB  . ASN A 1 402 ? 1.173   37.523  78.225  1.00 69.99  ?  383 ASN A CB  1 
ATOM   1653 C CG  . ASN A 1 402 ? -0.106  38.287  77.979  1.00 81.40  ?  383 ASN A CG  1 
ATOM   1654 O OD1 . ASN A 1 402 ? -0.355  39.320  78.602  1.00 94.38  ?  383 ASN A OD1 1 
ATOM   1655 N ND2 . ASN A 1 402 ? -0.943  37.772  77.091  1.00 85.76  ?  383 ASN A ND2 1 
ATOM   1656 N N   . ARG A 1 403 ? 4.228   36.768  77.546  1.00 82.73  ?  384 ARG A N   1 
ATOM   1657 C CA  . ARG A 1 403 ? 5.415   36.008  77.916  1.00 84.42  ?  384 ARG A CA  1 
ATOM   1658 C C   . ARG A 1 403 ? 6.634   36.919  77.995  1.00 78.77  ?  384 ARG A C   1 
ATOM   1659 O O   . ARG A 1 403 ? 7.460   36.800  78.916  1.00 72.86  ?  384 ARG A O   1 
ATOM   1660 C CB  . ARG A 1 403 ? 5.627   34.874  76.912  1.00 87.85  ?  384 ARG A CB  1 
ATOM   1661 C CG  . ARG A 1 403 ? 4.950   33.554  77.278  1.00 95.10  ?  384 ARG A CG  1 
ATOM   1662 C CD  . ARG A 1 403 ? 4.636   32.706  76.026  1.00 103.24 ?  384 ARG A CD  1 
ATOM   1663 N NE  . ARG A 1 403 ? 5.839   32.150  75.405  1.00 108.48 ?  384 ARG A NE  1 
ATOM   1664 C CZ  . ARG A 1 403 ? 6.653   31.269  75.987  1.00 111.80 ?  384 ARG A CZ  1 
ATOM   1665 N NH1 . ARG A 1 403 ? 6.388   30.789  77.206  1.00 110.61 ?  384 ARG A NH1 1 
ATOM   1666 N NH2 . ARG A 1 403 ? 7.741   30.862  75.345  1.00 106.41 ?  384 ARG A NH2 1 
ATOM   1667 N N   . LEU A 1 404 ? 6.744   37.852  77.045  1.00 77.03  ?  385 LEU A N   1 
ATOM   1668 C CA  . LEU A 1 404 ? 7.806   38.847  77.103  1.00 75.88  ?  385 LEU A CA  1 
ATOM   1669 C C   . LEU A 1 404 ? 7.732   39.667  78.380  1.00 76.63  ?  385 LEU A C   1 
ATOM   1670 O O   . LEU A 1 404 ? 8.771   40.037  78.945  1.00 75.56  ?  385 LEU A O   1 
ATOM   1671 C CB  . LEU A 1 404 ? 7.726   39.756  75.889  1.00 74.64  ?  385 LEU A CB  1 
ATOM   1672 C CG  . LEU A 1 404 ? 8.232   39.083  74.619  1.00 75.18  ?  385 LEU A CG  1 
ATOM   1673 C CD1 . LEU A 1 404 ? 7.778   39.864  73.389  1.00 73.16  ?  385 LEU A CD1 1 
ATOM   1674 C CD2 . LEU A 1 404 ? 9.734   38.983  74.664  1.00 72.60  ?  385 LEU A CD2 1 
ATOM   1675 N N   . LEU A 1 405 ? 6.524   39.937  78.875  1.00 76.17  ?  386 LEU A N   1 
ATOM   1676 C CA  . LEU A 1 405 ? 6.426   40.683  80.125  1.00 74.48  ?  386 LEU A CA  1 
ATOM   1677 C C   . LEU A 1 405 ? 6.978   39.881  81.299  1.00 78.68  ?  386 LEU A C   1 
ATOM   1678 O O   . LEU A 1 405 ? 7.856   40.372  82.018  1.00 76.96  ?  386 LEU A O   1 
ATOM   1679 C CB  . LEU A 1 405 ? 4.989   41.123  80.373  1.00 74.22  ?  386 LEU A CB  1 
ATOM   1680 C CG  . LEU A 1 405 ? 4.738   42.478  79.710  1.00 75.06  ?  386 LEU A CG  1 
ATOM   1681 C CD1 . LEU A 1 405 ? 3.272   42.857  79.715  1.00 73.01  ?  386 LEU A CD1 1 
ATOM   1682 C CD2 . LEU A 1 405 ? 5.588   43.550  80.374  1.00 73.44  ?  386 LEU A CD2 1 
ATOM   1683 N N   . GLU A 1 406 ? 6.498   38.636  81.504  1.00 78.34  ?  387 GLU A N   1 
ATOM   1684 C CA  . GLU A 1 406 ? 7.039   37.826  82.602  1.00 79.98  ?  387 GLU A CA  1 
ATOM   1685 C C   . GLU A 1 406 ? 8.551   37.667  82.486  1.00 80.08  ?  387 GLU A C   1 
ATOM   1686 O O   . GLU A 1 406 ? 9.253   37.555  83.506  1.00 73.81  ?  387 GLU A O   1 
ATOM   1687 C CB  . GLU A 1 406 ? 6.410   36.435  82.649  1.00 83.66  ?  387 GLU A CB  1 
ATOM   1688 C CG  . GLU A 1 406 ? 4.955   36.314  82.242  1.00 96.44  ?  387 GLU A CG  1 
ATOM   1689 C CD  . GLU A 1 406 ? 4.433   34.857  82.325  1.00 113.16 ?  387 GLU A CD  1 
ATOM   1690 O OE1 . GLU A 1 406 ? 3.302   34.603  81.837  1.00 114.12 ?  387 GLU A OE1 1 
ATOM   1691 O OE2 . GLU A 1 406 ? 5.144   33.969  82.874  1.00 115.08 ?  387 GLU A OE2 1 
ATOM   1692 N N   . ALA A 1 407 ? 9.064   37.636  81.254  1.00 75.48  ?  388 ALA A N   1 
ATOM   1693 C CA  . ALA A 1 407 ? 10.504  37.582  81.060  1.00 72.87  ?  388 ALA A CA  1 
ATOM   1694 C C   . ALA A 1 407 ? 11.202  38.757  81.748  1.00 75.97  ?  388 ALA A C   1 
ATOM   1695 O O   . ALA A 1 407 ? 12.214  38.574  82.441  1.00 74.27  ?  388 ALA A O   1 
ATOM   1696 C CB  . ALA A 1 407 ? 10.803  37.547  79.568  1.00 76.10  ?  388 ALA A CB  1 
ATOM   1697 N N   . THR A 1 408 ? 10.665  39.971  81.592  1.00 76.58  ?  389 THR A N   1 
ATOM   1698 C CA  . THR A 1 408 ? 11.308  41.126  82.221  1.00 77.36  ?  389 THR A CA  1 
ATOM   1699 C C   . THR A 1 408 ? 11.258  41.019  83.734  1.00 75.49  ?  389 THR A C   1 
ATOM   1700 O O   . THR A 1 408 ? 12.223  41.378  84.420  1.00 74.43  ?  389 THR A O   1 
ATOM   1701 C CB  . THR A 1 408 ? 10.658  42.435  81.771  1.00 75.69  ?  389 THR A CB  1 
ATOM   1702 O OG1 . THR A 1 408 ? 9.260   42.397  82.068  1.00 80.17  ?  389 THR A OG1 1 
ATOM   1703 C CG2 . THR A 1 408 ? 10.854  42.653  80.274  1.00 72.54  ?  389 THR A CG2 1 
ATOM   1704 N N   . SER A 1 409 ? 10.142  40.518  84.268  1.00 75.05  ?  390 SER A N   1 
ATOM   1705 C CA  . SER A 1 409 ? 10.034  40.337  85.707  1.00 69.90  ?  390 SER A CA  1 
ATOM   1706 C C   . SER A 1 409 ? 11.096  39.380  86.217  1.00 80.55  ?  390 SER A C   1 
ATOM   1707 O O   . SER A 1 409 ? 11.701  39.625  87.270  1.00 79.84  ?  390 SER A O   1 
ATOM   1708 C CB  . SER A 1 409 ? 8.643   39.844  86.058  1.00 68.31  ?  390 SER A CB  1 
ATOM   1709 O OG  . SER A 1 409 ? 8.408   40.055  87.429  1.00 77.87  ?  390 SER A OG  1 
ATOM   1710 N N   . TYR A 1 410 ? 11.345  38.290  85.468  1.00 81.08  ?  391 TYR A N   1 
ATOM   1711 C CA  . TYR A 1 410 ? 12.415  37.353  85.802  1.00 82.07  ?  391 TYR A CA  1 
ATOM   1712 C C   . TYR A 1 410 ? 13.769  38.057  85.838  1.00 88.11  ?  391 TYR A C   1 
ATOM   1713 O O   . TYR A 1 410 ? 14.460  38.042  86.865  1.00 91.93  ?  391 TYR A O   1 
ATOM   1714 C CB  . TYR A 1 410 ? 12.428  36.195  84.803  1.00 87.88  ?  391 TYR A CB  1 
ATOM   1715 C CG  . TYR A 1 410 ? 13.525  35.170  85.055  1.00 94.17  ?  391 TYR A CG  1 
ATOM   1716 C CD1 . TYR A 1 410 ? 14.730  35.217  84.358  1.00 92.93  ?  391 TYR A CD1 1 
ATOM   1717 C CD2 . TYR A 1 410 ? 13.354  34.161  85.992  1.00 103.28 ?  391 TYR A CD2 1 
ATOM   1718 C CE1 . TYR A 1 410 ? 15.736  34.294  84.593  1.00 99.65  ?  391 TYR A CE1 1 
ATOM   1719 C CE2 . TYR A 1 410 ? 14.352  33.225  86.233  1.00 107.45 ?  391 TYR A CE2 1 
ATOM   1720 C CZ  . TYR A 1 410 ? 15.542  33.296  85.529  1.00 106.48 ?  391 TYR A CZ  1 
ATOM   1721 O OH  . TYR A 1 410 ? 16.532  32.367  85.770  1.00 108.84 ?  391 TYR A OH  1 
ATOM   1722 N N   . LEU A 1 411 ? 14.176  38.660  84.710  1.00 82.80  ?  392 LEU A N   1 
ATOM   1723 C CA  . LEU A 1 411 ? 15.281  39.620  84.702  1.00 87.20  ?  392 LEU A CA  1 
ATOM   1724 C C   . LEU A 1 411 ? 15.332  40.553  85.903  1.00 90.66  ?  392 LEU A C   1 
ATOM   1725 O O   . LEU A 1 411 ? 16.418  40.832  86.419  1.00 95.27  ?  392 LEU A O   1 
ATOM   1726 C CB  . LEU A 1 411 ? 15.246  40.492  83.449  1.00 87.07  ?  392 LEU A CB  1 
ATOM   1727 C CG  . LEU A 1 411 ? 15.768  40.005  82.120  1.00 87.49  ?  392 LEU A CG  1 
ATOM   1728 C CD1 . LEU A 1 411 ? 15.326  40.956  81.044  1.00 81.63  ?  392 LEU A CD1 1 
ATOM   1729 C CD2 . LEU A 1 411 ? 17.274  40.169  82.305  1.00 95.49  ?  392 LEU A CD2 1 
ATOM   1730 N N   . SER A 1 412 ? 14.183  41.070  86.341  1.00 85.97  ?  393 SER A N   1 
ATOM   1731 C CA  . SER A 1 412 ? 14.231  42.069  87.401  1.00 90.19  ?  393 SER A CA  1 
ATOM   1732 C C   . SER A 1 412 ? 14.436  41.420  88.766  1.00 91.83  ?  393 SER A C   1 
ATOM   1733 O O   . SER A 1 412 ? 15.381  41.770  89.484  1.00 93.30  ?  393 SER A O   1 
ATOM   1734 C CB  . SER A 1 412 ? 12.967  42.939  87.381  1.00 88.88  ?  393 SER A CB  1 
ATOM   1735 O OG  . SER A 1 412 ? 12.914  43.787  88.520  1.00 85.10  ?  393 SER A OG  1 
ATOM   1736 N N   . HIS A 1 413 ? 13.583  40.454  89.133  1.00 92.24  ?  394 HIS A N   1 
ATOM   1737 C CA  . HIS A 1 413 ? 13.566  39.938  90.502  1.00 98.32  ?  394 HIS A CA  1 
ATOM   1738 C C   . HIS A 1 413 ? 14.442  38.701  90.698  1.00 103.17 ?  394 HIS A C   1 
ATOM   1739 O O   . HIS A 1 413 ? 14.664  38.294  91.845  1.00 109.46 ?  394 HIS A O   1 
ATOM   1740 C CB  . HIS A 1 413 ? 12.118  39.636  90.939  1.00 94.51  ?  394 HIS A CB  1 
ATOM   1741 C CG  . HIS A 1 413 ? 11.163  40.768  90.687  1.00 99.67  ?  394 HIS A CG  1 
ATOM   1742 N ND1 . HIS A 1 413 ? 9.964   40.602  90.024  1.00 98.85  ?  394 HIS A ND1 1 
ATOM   1743 C CD2 . HIS A 1 413 ? 11.251  42.093  90.973  1.00 104.75 ?  394 HIS A CD2 1 
ATOM   1744 C CE1 . HIS A 1 413 ? 9.350   41.771  89.920  1.00 101.83 ?  394 HIS A CE1 1 
ATOM   1745 N NE2 . HIS A 1 413 ? 10.111  42.693  90.486  1.00 104.68 ?  394 HIS A NE2 1 
ATOM   1746 N N   . GLN A 1 414 ? 14.972  38.117  89.623  1.00 99.40  ?  395 GLN A N   1 
ATOM   1747 C CA  . GLN A 1 414 ? 15.762  36.901  89.721  1.00 103.10 ?  395 GLN A CA  1 
ATOM   1748 C C   . GLN A 1 414 ? 17.200  37.038  89.247  1.00 103.24 ?  395 GLN A C   1 
ATOM   1749 O O   . GLN A 1 414 ? 18.030  36.212  89.638  1.00 106.17 ?  395 GLN A O   1 
ATOM   1750 C CB  . GLN A 1 414 ? 15.099  35.767  88.927  1.00 105.82 ?  395 GLN A CB  1 
ATOM   1751 C CG  . GLN A 1 414 ? 13.636  35.532  89.278  1.00 108.31 ?  395 GLN A CG  1 
ATOM   1752 C CD  . GLN A 1 414 ? 13.466  34.859  90.617  1.00 118.99 ?  395 GLN A CD  1 
ATOM   1753 O OE1 . GLN A 1 414 ? 14.363  34.149  91.086  1.00 123.85 ?  395 GLN A OE1 1 
ATOM   1754 N NE2 . GLN A 1 414 ? 12.314  35.076  91.245  1.00 122.66 ?  395 GLN A NE2 1 
ATOM   1755 N N   . LEU A 1 415 ? 17.524  38.032  88.417  1.00 98.31  ?  396 LEU A N   1 
ATOM   1756 C CA  . LEU A 1 415 ? 18.898  38.241  87.978  1.00 98.59  ?  396 LEU A CA  1 
ATOM   1757 C C   . LEU A 1 415 ? 19.480  39.579  88.416  1.00 101.01 ?  396 LEU A C   1 
ATOM   1758 O O   . LEU A 1 415 ? 20.613  39.897  88.027  1.00 101.11 ?  396 LEU A O   1 
ATOM   1759 C CB  . LEU A 1 415 ? 19.001  38.108  86.451  1.00 101.17 ?  396 LEU A CB  1 
ATOM   1760 C CG  . LEU A 1 415 ? 18.440  36.824  85.813  1.00 97.39  ?  396 LEU A CG  1 
ATOM   1761 C CD1 . LEU A 1 415 ? 18.821  36.728  84.349  1.00 94.15  ?  396 LEU A CD1 1 
ATOM   1762 C CD2 . LEU A 1 415 ? 18.921  35.606  86.543  1.00 96.08  ?  396 LEU A CD2 1 
ATOM   1763 N N   . ASP A 1 416 ? 18.735  40.364  89.211  1.00 105.20 ?  397 ASP A N   1 
ATOM   1764 C CA  . ASP A 1 416 ? 19.141  41.695  89.702  1.00 105.48 ?  397 ASP A CA  1 
ATOM   1765 C C   . ASP A 1 416 ? 19.681  42.596  88.585  1.00 100.88 ?  397 ASP A C   1 
ATOM   1766 O O   . ASP A 1 416 ? 20.499  43.494  88.824  1.00 106.89 ?  397 ASP A O   1 
ATOM   1767 C CB  . ASP A 1 416 ? 20.152  41.580  90.853  1.00 110.19 ?  397 ASP A CB  1 
ATOM   1768 C CG  . ASP A 1 416 ? 20.089  42.770  91.825  1.00 117.75 ?  397 ASP A CG  1 
ATOM   1769 O OD1 . ASP A 1 416 ? 19.610  43.867  91.430  1.00 117.95 ?  397 ASP A OD1 1 
ATOM   1770 O OD2 . ASP A 1 416 ? 20.522  42.603  92.992  1.00 121.69 ?  397 ASP A OD2 1 
ATOM   1771 N N   . PHE A 1 417 ? 19.200  42.390  87.359  1.00 92.68  ?  398 PHE A N   1 
ATOM   1772 C CA  . PHE A 1 417 ? 19.550  43.241  86.221  1.00 95.78  ?  398 PHE A CA  1 
ATOM   1773 C C   . PHE A 1 417 ? 18.750  44.549  86.310  1.00 95.56  ?  398 PHE A C   1 
ATOM   1774 O O   . PHE A 1 417 ? 17.871  44.848  85.503  1.00 94.73  ?  398 PHE A O   1 
ATOM   1775 C CB  . PHE A 1 417 ? 19.278  42.482  84.921  1.00 94.91  ?  398 PHE A CB  1 
ATOM   1776 C CG  . PHE A 1 417 ? 19.543  43.270  83.655  1.00 91.50  ?  398 PHE A CG  1 
ATOM   1777 C CD1 . PHE A 1 417 ? 20.833  43.630  83.288  1.00 93.27  ?  398 PHE A CD1 1 
ATOM   1778 C CD2 . PHE A 1 417 ? 18.494  43.631  82.818  1.00 88.41  ?  398 PHE A CD2 1 
ATOM   1779 C CE1 . PHE A 1 417 ? 21.068  44.338  82.108  1.00 94.38  ?  398 PHE A CE1 1 
ATOM   1780 C CE2 . PHE A 1 417 ? 18.719  44.352  81.648  1.00 84.95  ?  398 PHE A CE2 1 
ATOM   1781 C CZ  . PHE A 1 417 ? 20.006  44.699  81.290  1.00 88.18  ?  398 PHE A CZ  1 
ATOM   1782 N N   . ASN A 1 418 ? 19.041  45.347  87.336  1.00 97.69  ?  399 ASN A N   1 
ATOM   1783 C CA  . ASN A 1 418 ? 18.297  46.584  87.470  1.00 94.23  ?  399 ASN A CA  1 
ATOM   1784 C C   . ASN A 1 418 ? 19.145  47.835  87.385  1.00 96.13  ?  399 ASN A C   1 
ATOM   1785 O O   . ASN A 1 418 ? 18.592  48.933  87.495  1.00 91.79  ?  399 ASN A O   1 
ATOM   1786 C CB  . ASN A 1 418 ? 17.471  46.608  88.755  1.00 91.76  ?  399 ASN A CB  1 
ATOM   1787 C CG  . ASN A 1 418 ? 16.382  45.558  88.752  1.00 97.14  ?  399 ASN A CG  1 
ATOM   1788 O OD1 . ASN A 1 418 ? 16.357  44.670  89.611  1.00 101.14 ?  399 ASN A OD1 1 
ATOM   1789 N ND2 . ASN A 1 418 ? 15.500  45.616  87.742  1.00 91.30  ?  399 ASN A ND2 1 
ATOM   1790 N N   . VAL A 1 419 ? 20.444  47.718  87.141  1.00 100.10 ?  400 VAL A N   1 
ATOM   1791 C CA  . VAL A 1 419 ? 21.259  48.874  86.790  1.00 100.46 ?  400 VAL A CA  1 
ATOM   1792 C C   . VAL A 1 419 ? 22.185  48.485  85.638  1.00 101.46 ?  400 VAL A C   1 
ATOM   1793 O O   . VAL A 1 419 ? 22.746  47.385  85.626  1.00 104.91 ?  400 VAL A O   1 
ATOM   1794 C CB  . VAL A 1 419 ? 22.047  49.398  88.011  1.00 102.24 ?  400 VAL A CB  1 
ATOM   1795 C CG1 . VAL A 1 419 ? 23.168  50.336  87.568  1.00 104.12 ?  400 VAL A CG1 1 
ATOM   1796 C CG2 . VAL A 1 419 ? 21.104  50.070  89.029  1.00 95.59  ?  400 VAL A CG2 1 
ATOM   1797 N N   . LEU A 1 420 ? 22.325  49.382  84.659  1.00 104.36 ?  401 LEU A N   1 
ATOM   1798 C CA  . LEU A 1 420 ? 23.169  49.157  83.489  1.00 105.85 ?  401 LEU A CA  1 
ATOM   1799 C C   . LEU A 1 420 ? 23.884  50.462  83.167  1.00 114.77 ?  401 LEU A C   1 
ATOM   1800 O O   . LEU A 1 420 ? 23.231  51.440  82.775  1.00 113.37 ?  401 LEU A O   1 
ATOM   1801 C CB  . LEU A 1 420 ? 22.333  48.733  82.278  1.00 107.83 ?  401 LEU A CB  1 
ATOM   1802 C CG  . LEU A 1 420 ? 23.011  48.139  81.033  1.00 108.65 ?  401 LEU A CG  1 
ATOM   1803 C CD1 . LEU A 1 420 ? 21.973  47.375  80.229  1.00 101.45 ?  401 LEU A CD1 1 
ATOM   1804 C CD2 . LEU A 1 420 ? 23.807  49.102  80.140  1.00 114.65 ?  401 LEU A CD2 1 
ATOM   1805 N N   . ASN A 1 421 ? 25.214  50.470  83.292  1.00 118.49 ?  402 ASN A N   1 
ATOM   1806 C CA  . ASN A 1 421 ? 26.032  51.654  82.996  1.00 121.27 ?  402 ASN A CA  1 
ATOM   1807 C C   . ASN A 1 421 ? 25.748  52.785  83.983  1.00 120.69 ?  402 ASN A C   1 
ATOM   1808 O O   . ASN A 1 421 ? 25.663  53.958  83.601  1.00 123.45 ?  402 ASN A O   1 
ATOM   1809 C CB  . ASN A 1 421 ? 25.836  52.151  81.553  1.00 121.38 ?  402 ASN A CB  1 
ATOM   1810 C CG  . ASN A 1 421 ? 26.457  51.231  80.506  1.00 126.94 ?  402 ASN A CG  1 
ATOM   1811 O OD1 . ASN A 1 421 ? 26.974  50.147  80.819  1.00 128.67 ?  402 ASN A OD1 1 
ATOM   1812 N ND2 . ASN A 1 421 ? 26.427  51.676  79.249  1.00 123.09 ?  402 ASN A ND2 1 
ATOM   1813 N N   . ASN A 1 422 ? 25.599  52.426  85.261  1.00 118.19 ?  403 ASN A N   1 
ATOM   1814 C CA  . ASN A 1 422 ? 25.357  53.386  86.349  1.00 123.02 ?  403 ASN A CA  1 
ATOM   1815 C C   . ASN A 1 422 ? 24.017  54.113  86.195  1.00 120.20 ?  403 ASN A C   1 
ATOM   1816 O O   . ASN A 1 422 ? 23.846  55.224  86.700  1.00 125.22 ?  403 ASN A O   1 
ATOM   1817 C CB  . ASN A 1 422 ? 26.501  54.412  86.472  1.00 127.93 ?  403 ASN A CB  1 
ATOM   1818 C CG  . ASN A 1 422 ? 27.867  53.771  86.707  1.00 132.31 ?  403 ASN A CG  1 
ATOM   1819 O OD1 . ASN A 1 422 ? 28.085  53.095  87.720  1.00 132.83 ?  403 ASN A OD1 1 
ATOM   1820 N ND2 . ASN A 1 422 ? 28.801  54.003  85.780  1.00 126.41 ?  403 ASN A ND2 1 
ATOM   1821 N N   . LYS A 1 423 ? 23.061  53.506  85.500  1.00 114.05 ?  404 LYS A N   1 
ATOM   1822 C CA  . LYS A 1 423 ? 21.762  54.118  85.268  1.00 105.32 ?  404 LYS A CA  1 
ATOM   1823 C C   . LYS A 1 423 ? 20.713  53.045  85.510  1.00 102.14 ?  404 LYS A C   1 
ATOM   1824 O O   . LYS A 1 423 ? 20.950  51.862  85.215  1.00 100.93 ?  404 LYS A O   1 
ATOM   1825 C CB  . LYS A 1 423 ? 21.602  54.621  83.827  1.00 108.09 ?  404 LYS A CB  1 
ATOM   1826 C CG  . LYS A 1 423 ? 22.598  55.643  83.378  1.00 110.80 ?  404 LYS A CG  1 
ATOM   1827 C CD  . LYS A 1 423 ? 22.206  56.253  82.040  1.00 111.45 ?  404 LYS A CD  1 
ATOM   1828 C CE  . LYS A 1 423 ? 22.363  55.245  80.928  1.00 117.23 ?  404 LYS A CE  1 
ATOM   1829 N NZ  . LYS A 1 423 ? 22.186  55.893  79.605  1.00 119.79 ?  404 LYS A NZ  1 
ATOM   1830 N N   . PRO A 1 424 ? 19.535  53.413  86.011  1.00 99.36  ?  405 PRO A N   1 
ATOM   1831 C CA  . PRO A 1 424 ? 18.513  52.406  86.283  1.00 91.71  ?  405 PRO A CA  1 
ATOM   1832 C C   . PRO A 1 424 ? 17.937  51.876  84.986  1.00 84.73  ?  405 PRO A C   1 
ATOM   1833 O O   . PRO A 1 424 ? 17.799  52.596  83.998  1.00 88.79  ?  405 PRO A O   1 
ATOM   1834 C CB  . PRO A 1 424 ? 17.464  53.151  87.096  1.00 83.31  ?  405 PRO A CB  1 
ATOM   1835 C CG  . PRO A 1 424 ? 17.709  54.585  86.825  1.00 91.64  ?  405 PRO A CG  1 
ATOM   1836 C CD  . PRO A 1 424 ? 19.063  54.775  86.224  1.00 93.96  ?  405 PRO A CD  1 
ATOM   1837 N N   . VAL A 1 425 ? 17.600  50.602  84.990  1.00 77.47  ?  406 VAL A N   1 
ATOM   1838 C CA  . VAL A 1 425 ? 17.088  49.968  83.785  1.00 76.99  ?  406 VAL A CA  1 
ATOM   1839 C C   . VAL A 1 425 ? 15.619  50.310  83.613  1.00 69.30  ?  406 VAL A C   1 
ATOM   1840 O O   . VAL A 1 425 ? 14.847  50.307  84.580  1.00 67.16  ?  406 VAL A O   1 
ATOM   1841 C CB  . VAL A 1 425 ? 17.314  48.450  83.853  1.00 77.33  ?  406 VAL A CB  1 
ATOM   1842 C CG1 . VAL A 1 425 ? 16.833  47.806  82.586  1.00 70.55  ?  406 VAL A CG1 1 
ATOM   1843 C CG2 . VAL A 1 425 ? 18.792  48.164  84.063  1.00 82.66  ?  406 VAL A CG2 1 
ATOM   1844 N N   . SER A 1 426 ? 15.227  50.605  82.381  1.00 67.39  ?  407 SER A N   1 
ATOM   1845 C CA  . SER A 1 426 ? 13.819  50.823  82.099  1.00 70.53  ?  407 SER A CA  1 
ATOM   1846 C C   . SER A 1 426 ? 13.139  49.539  81.620  1.00 70.92  ?  407 SER A C   1 
ATOM   1847 O O   . SER A 1 426 ? 13.779  48.539  81.302  1.00 71.71  ?  407 SER A O   1 
ATOM   1848 C CB  . SER A 1 426 ? 13.631  51.935  81.068  1.00 67.85  ?  407 SER A CB  1 
ATOM   1849 O OG  . SER A 1 426 ? 14.071  51.551  79.783  1.00 71.84  ?  407 SER A OG  1 
ATOM   1850 N N   . LEU A 1 427 ? 11.809  49.581  81.577  1.00 66.19  ?  408 LEU A N   1 
ATOM   1851 C CA  . LEU A 1 427 ? 11.062  48.468  81.021  1.00 63.56  ?  408 LEU A CA  1 
ATOM   1852 C C   . LEU A 1 427 ? 11.439  48.250  79.563  1.00 66.67  ?  408 LEU A C   1 
ATOM   1853 O O   . LEU A 1 427 ? 11.797  47.139  79.169  1.00 71.72  ?  408 LEU A O   1 
ATOM   1854 C CB  . LEU A 1 427 ? 9.560   48.714  81.172  1.00 60.43  ?  408 LEU A CB  1 
ATOM   1855 C CG  . LEU A 1 427 ? 8.665   47.543  80.756  1.00 59.86  ?  408 LEU A CG  1 
ATOM   1856 C CD1 . LEU A 1 427 ? 9.147   46.290  81.415  1.00 56.98  ?  408 LEU A CD1 1 
ATOM   1857 C CD2 . LEU A 1 427 ? 7.225   47.789  81.096  1.00 55.72  ?  408 LEU A CD2 1 
ATOM   1858 N N   . GLY A 1 428 ? 11.374  49.306  78.750  1.00 68.47  ?  409 GLY A N   1 
ATOM   1859 C CA  . GLY A 1 428 ? 11.721  49.180  77.343  1.00 62.19  ?  409 GLY A CA  1 
ATOM   1860 C C   . GLY A 1 428 ? 13.098  48.581  77.122  1.00 67.07  ?  409 GLY A C   1 
ATOM   1861 O O   . GLY A 1 428 ? 13.275  47.708  76.274  1.00 69.50  ?  409 GLY A O   1 
ATOM   1862 N N   . GLN A 1 429 ? 14.094  49.052  77.870  1.00 68.00  ?  410 GLN A N   1 
ATOM   1863 C CA  . GLN A 1 429 ? 15.411  48.434  77.827  1.00 68.12  ?  410 GLN A CA  1 
ATOM   1864 C C   . GLN A 1 429 ? 15.316  46.934  78.051  1.00 72.08  ?  410 GLN A C   1 
ATOM   1865 O O   . GLN A 1 429 ? 15.868  46.142  77.284  1.00 79.84  ?  410 GLN A O   1 
ATOM   1866 C CB  . GLN A 1 429 ? 16.312  49.048  78.888  1.00 70.93  ?  410 GLN A CB  1 
ATOM   1867 C CG  . GLN A 1 429 ? 17.213  50.132  78.412  1.00 75.28  ?  410 GLN A CG  1 
ATOM   1868 C CD  . GLN A 1 429 ? 17.884  50.822  79.575  1.00 88.70  ?  410 GLN A CD  1 
ATOM   1869 O OE1 . GLN A 1 429 ? 17.431  51.876  80.046  1.00 95.12  ?  410 GLN A OE1 1 
ATOM   1870 N NE2 . GLN A 1 429 ? 18.953  50.207  80.080  1.00 90.86  ?  410 GLN A NE2 1 
ATOM   1871 N N   . ALA A 1 430 ? 14.614  46.524  79.109  1.00 74.94  ?  411 ALA A N   1 
ATOM   1872 C CA  . ALA A 1 430 ? 14.515  45.110  79.450  1.00 68.66  ?  411 ALA A CA  1 
ATOM   1873 C C   . ALA A 1 430 ? 13.767  44.320  78.390  1.00 68.88  ?  411 ALA A C   1 
ATOM   1874 O O   . ALA A 1 430 ? 14.104  43.163  78.141  1.00 79.67  ?  411 ALA A O   1 
ATOM   1875 C CB  . ALA A 1 430 ? 13.835  44.945  80.806  1.00 70.28  ?  411 ALA A CB  1 
ATOM   1876 N N   . LEU A 1 431 ? 12.766  44.913  77.747  1.00 67.45  ?  412 LEU A N   1 
ATOM   1877 C CA  . LEU A 1 431 ? 12.073  44.214  76.667  1.00 72.22  ?  412 LEU A CA  1 
ATOM   1878 C C   . LEU A 1 431 ? 12.992  43.958  75.473  1.00 77.13  ?  412 LEU A C   1 
ATOM   1879 O O   . LEU A 1 431 ? 13.029  42.841  74.940  1.00 78.71  ?  412 LEU A O   1 
ATOM   1880 C CB  . LEU A 1 431 ? 10.845  44.998  76.227  1.00 66.18  ?  412 LEU A CB  1 
ATOM   1881 C CG  . LEU A 1 431 ? 9.692   44.894  77.203  1.00 67.86  ?  412 LEU A CG  1 
ATOM   1882 C CD1 . LEU A 1 431 ? 8.579   45.783  76.720  1.00 67.39  ?  412 LEU A CD1 1 
ATOM   1883 C CD2 . LEU A 1 431 ? 9.223   43.457  77.329  1.00 67.67  ?  412 LEU A CD2 1 
ATOM   1884 N N   . GLU A 1 432 ? 13.711  44.986  75.003  1.00 73.07  ?  413 GLU A N   1 
ATOM   1885 C CA  . GLU A 1 432 ? 14.709  44.741  73.968  1.00 77.83  ?  413 GLU A CA  1 
ATOM   1886 C C   . GLU A 1 432 ? 15.665  43.621  74.362  1.00 80.49  ?  413 GLU A C   1 
ATOM   1887 O O   . GLU A 1 432 ? 15.905  42.707  73.569  1.00 83.29  ?  413 GLU A O   1 
ATOM   1888 C CB  . GLU A 1 432 ? 15.468  46.016  73.607  1.00 79.95  ?  413 GLU A CB  1 
ATOM   1889 C CG  . GLU A 1 432 ? 14.756  46.952  72.637  1.00 93.84  ?  413 GLU A CG  1 
ATOM   1890 C CD  . GLU A 1 432 ? 15.519  48.274  72.440  1.00 112.50 ?  413 GLU A CD  1 
ATOM   1891 O OE1 . GLU A 1 432 ? 16.421  48.573  73.265  1.00 111.68 ?  413 GLU A OE1 1 
ATOM   1892 O OE2 . GLU A 1 432 ? 15.284  48.968  71.417  1.00 124.02 ?  413 GLU A OE2 1 
ATOM   1893 N N   . VAL A 1 433 ? 16.194  43.643  75.586  1.00 73.00  ?  414 VAL A N   1 
ATOM   1894 C CA  . VAL A 1 433 ? 17.175  42.622  75.950  1.00 78.42  ?  414 VAL A CA  1 
ATOM   1895 C C   . VAL A 1 433 ? 16.537  41.230  75.964  1.00 84.61  ?  414 VAL A C   1 
ATOM   1896 O O   . VAL A 1 433 ? 17.171  40.241  75.581  1.00 88.58  ?  414 VAL A O   1 
ATOM   1897 C CB  . VAL A 1 433 ? 17.855  42.955  77.291  1.00 79.12  ?  414 VAL A CB  1 
ATOM   1898 C CG1 . VAL A 1 433 ? 18.497  41.695  77.893  1.00 77.96  ?  414 VAL A CG1 1 
ATOM   1899 C CG2 . VAL A 1 433 ? 18.893  44.041  77.092  1.00 74.53  ?  414 VAL A CG2 1 
ATOM   1900 N N   . VAL A 1 434 ? 15.273  41.123  76.371  1.00 81.43  ?  415 VAL A N   1 
ATOM   1901 C CA  . VAL A 1 434 ? 14.595  39.836  76.253  1.00 80.42  ?  415 VAL A CA  1 
ATOM   1902 C C   . VAL A 1 434 ? 14.438  39.454  74.784  1.00 80.48  ?  415 VAL A C   1 
ATOM   1903 O O   . VAL A 1 434 ? 14.747  38.329  74.385  1.00 87.01  ?  415 VAL A O   1 
ATOM   1904 C CB  . VAL A 1 434 ? 13.242  39.862  76.983  1.00 76.43  ?  415 VAL A CB  1 
ATOM   1905 C CG1 . VAL A 1 434 ? 12.417  38.675  76.590  1.00 74.67  ?  415 VAL A CG1 1 
ATOM   1906 C CG2 . VAL A 1 434 ? 13.469  39.824  78.452  1.00 72.31  ?  415 VAL A CG2 1 
ATOM   1907 N N   . ILE A 1 435 ? 13.974  40.385  73.953  1.00 80.03  ?  416 ILE A N   1 
ATOM   1908 C CA  . ILE A 1 435 ? 13.718  40.050  72.555  1.00 80.40  ?  416 ILE A CA  1 
ATOM   1909 C C   . ILE A 1 435 ? 15.009  39.646  71.858  1.00 84.61  ?  416 ILE A C   1 
ATOM   1910 O O   . ILE A 1 435 ? 15.062  38.632  71.161  1.00 88.62  ?  416 ILE A O   1 
ATOM   1911 C CB  . ILE A 1 435 ? 13.029  41.214  71.829  1.00 73.82  ?  416 ILE A CB  1 
ATOM   1912 C CG1 . ILE A 1 435 ? 11.579  41.318  72.295  1.00 76.54  ?  416 ILE A CG1 1 
ATOM   1913 C CG2 . ILE A 1 435 ? 13.077  40.969  70.355  1.00 74.30  ?  416 ILE A CG2 1 
ATOM   1914 C CD1 . ILE A 1 435 ? 10.708  42.253  71.485  1.00 76.06  ?  416 ILE A CD1 1 
ATOM   1915 N N   . GLN A 1 436 ? 16.073  40.424  72.042  1.00 87.60  ?  417 GLN A N   1 
ATOM   1916 C CA  . GLN A 1 436 ? 17.346  40.054  71.437  1.00 85.21  ?  417 GLN A CA  1 
ATOM   1917 C C   . GLN A 1 436 ? 17.750  38.643  71.855  1.00 88.55  ?  417 GLN A C   1 
ATOM   1918 O O   . GLN A 1 436 ? 18.138  37.832  71.010  1.00 92.49  ?  417 GLN A O   1 
ATOM   1919 C CB  . GLN A 1 436 ? 18.425  41.088  71.788  1.00 83.48  ?  417 GLN A CB  1 
ATOM   1920 C CG  . GLN A 1 436 ? 18.224  42.429  71.044  1.00 89.55  ?  417 GLN A CG  1 
ATOM   1921 C CD  . GLN A 1 436 ? 18.896  43.637  71.714  1.00 94.65  ?  417 GLN A CD  1 
ATOM   1922 O OE1 . GLN A 1 436 ? 19.556  43.517  72.748  1.00 94.25  ?  417 GLN A OE1 1 
ATOM   1923 N NE2 . GLN A 1 436 ? 18.715  44.813  71.119  1.00 100.35 ?  417 GLN A NE2 1 
ATOM   1924 N N   . LEU A 1 437 ? 17.599  38.301  73.137  1.00 86.89  ?  418 LEU A N   1 
ATOM   1925 C CA  . LEU A 1 437 ? 17.952  36.948  73.562  1.00 85.76  ?  418 LEU A CA  1 
ATOM   1926 C C   . LEU A 1 437 ? 17.041  35.870  72.973  1.00 87.85  ?  418 LEU A C   1 
ATOM   1927 O O   . LEU A 1 437 ? 17.480  34.726  72.834  1.00 89.45  ?  418 LEU A O   1 
ATOM   1928 C CB  . LEU A 1 437 ? 17.965  36.843  75.091  1.00 83.92  ?  418 LEU A CB  1 
ATOM   1929 C CG  . LEU A 1 437 ? 19.060  37.678  75.750  1.00 87.45  ?  418 LEU A CG  1 
ATOM   1930 C CD1 . LEU A 1 437 ? 19.288  37.306  77.217  1.00 94.86  ?  418 LEU A CD1 1 
ATOM   1931 C CD2 . LEU A 1 437 ? 20.324  37.535  74.951  1.00 92.73  ?  418 LEU A CD2 1 
ATOM   1932 N N   . GLN A 1 438 ? 15.791  36.182  72.636  1.00 86.87  ?  419 GLN A N   1 
ATOM   1933 C CA  . GLN A 1 438 ? 14.999  35.196  71.910  1.00 85.98  ?  419 GLN A CA  1 
ATOM   1934 C C   . GLN A 1 438 ? 15.460  35.100  70.465  1.00 89.70  ?  419 GLN A C   1 
ATOM   1935 O O   . GLN A 1 438 ? 15.612  34.001  69.931  1.00 92.40  ?  419 GLN A O   1 
ATOM   1936 C CB  . GLN A 1 438 ? 13.504  35.526  71.964  1.00 84.09  ?  419 GLN A CB  1 
ATOM   1937 C CG  . GLN A 1 438 ? 12.923  35.484  73.344  1.00 83.27  ?  419 GLN A CG  1 
ATOM   1938 C CD  . GLN A 1 438 ? 13.651  34.512  74.230  1.00 92.38  ?  419 GLN A CD  1 
ATOM   1939 O OE1 . GLN A 1 438 ? 14.502  34.903  75.040  1.00 87.67  ?  419 GLN A OE1 1 
ATOM   1940 N NE2 . GLN A 1 438 ? 13.313  33.232  74.101  1.00 97.71  ?  419 GLN A NE2 1 
ATOM   1941 N N   . GLU A 1 439 ? 15.683  36.241  69.817  1.00 94.08  ?  420 GLU A N   1 
ATOM   1942 C CA  . GLU A 1 439 ? 16.289  36.224  68.493  1.00 91.56  ?  420 GLU A CA  1 
ATOM   1943 C C   . GLU A 1 439 ? 17.624  35.472  68.505  1.00 92.73  ?  420 GLU A C   1 
ATOM   1944 O O   . GLU A 1 439 ? 17.879  34.648  67.619  1.00 91.71  ?  420 GLU A O   1 
ATOM   1945 C CB  . GLU A 1 439 ? 16.452  37.656  67.977  1.00 86.81  ?  420 GLU A CB  1 
ATOM   1946 C CG  . GLU A 1 439 ? 15.317  38.100  67.055  1.00 92.58  ?  420 GLU A CG  1 
ATOM   1947 C CD  . GLU A 1 439 ? 15.316  39.610  66.756  1.00 107.70 ?  420 GLU A CD  1 
ATOM   1948 O OE1 . GLU A 1 439 ? 14.495  40.038  65.907  1.00 110.76 ?  420 GLU A OE1 1 
ATOM   1949 O OE2 . GLU A 1 439 ? 16.114  40.368  67.368  1.00 104.06 ?  420 GLU A OE2 1 
ATOM   1950 N N   . LYS A 1 440 ? 18.475  35.712  69.514  1.00 90.22  ?  421 LYS A N   1 
ATOM   1951 C CA  . LYS A 1 440 ? 19.758  35.013  69.575  1.00 86.88  ?  421 LYS A CA  1 
ATOM   1952 C C   . LYS A 1 440 ? 19.548  33.511  69.672  1.00 95.75  ?  421 LYS A C   1 
ATOM   1953 O O   . LYS A 1 440 ? 20.177  32.729  68.946  1.00 99.85  ?  421 LYS A O   1 
ATOM   1954 C CB  . LYS A 1 440 ? 20.609  35.484  70.759  1.00 84.03  ?  421 LYS A CB  1 
ATOM   1955 C CG  . LYS A 1 440 ? 21.641  34.440  71.145  1.00 84.82  ?  421 LYS A CG  1 
ATOM   1956 C CD  . LYS A 1 440 ? 22.360  34.665  72.440  1.00 86.59  ?  421 LYS A CD  1 
ATOM   1957 C CE  . LYS A 1 440 ? 22.891  33.311  72.924  1.00 101.70 ?  421 LYS A CE  1 
ATOM   1958 N NZ  . LYS A 1 440 ? 23.670  33.315  74.196  1.00 101.85 ?  421 LYS A NZ  1 
ATOM   1959 N N   . HIS A 1 441 ? 18.666  33.083  70.566  1.00 95.42  ?  422 HIS A N   1 
ATOM   1960 C CA  . HIS A 1 441 ? 18.475  31.653  70.739  1.00 92.93  ?  422 HIS A CA  1 
ATOM   1961 C C   . HIS A 1 441 ? 17.835  31.009  69.509  1.00 92.10  ?  422 HIS A C   1 
ATOM   1962 O O   . HIS A 1 441 ? 18.057  29.826  69.266  1.00 98.30  ?  422 HIS A O   1 
ATOM   1963 C CB  . HIS A 1 441 ? 17.660  31.391  71.997  1.00 94.38  ?  422 HIS A CB  1 
ATOM   1964 C CG  . HIS A 1 441 ? 17.079  30.020  72.056  1.00 98.13  ?  422 HIS A CG  1 
ATOM   1965 N ND1 . HIS A 1 441 ? 15.918  29.675  71.393  1.00 96.06  ?  422 HIS A ND1 1 
ATOM   1966 C CD2 . HIS A 1 441 ? 17.502  28.902  72.689  1.00 95.24  ?  422 HIS A CD2 1 
ATOM   1967 C CE1 . HIS A 1 441 ? 15.645  28.405  71.623  1.00 90.57  ?  422 HIS A CE1 1 
ATOM   1968 N NE2 . HIS A 1 441 ? 16.589  27.915  72.408  1.00 96.51  ?  422 HIS A NE2 1 
ATOM   1969 N N   . VAL A 1 442 ? 17.062  31.749  68.710  1.00 88.72  ?  423 VAL A N   1 
ATOM   1970 C CA  . VAL A 1 442 ? 16.643  31.214  67.411  1.00 88.92  ?  423 VAL A CA  1 
ATOM   1971 C C   . VAL A 1 442 ? 17.847  30.927  66.516  1.00 95.46  ?  423 VAL A C   1 
ATOM   1972 O O   . VAL A 1 442 ? 17.923  29.869  65.879  1.00 97.73  ?  423 VAL A O   1 
ATOM   1973 C CB  . VAL A 1 442 ? 15.636  32.155  66.727  1.00 84.64  ?  423 VAL A CB  1 
ATOM   1974 C CG1 . VAL A 1 442 ? 15.469  31.777  65.286  1.00 91.51  ?  423 VAL A CG1 1 
ATOM   1975 C CG2 . VAL A 1 442 ? 14.286  32.000  67.380  1.00 88.15  ?  423 VAL A CG2 1 
ATOM   1976 N N   . LYS A 1 443 ? 18.800  31.857  66.444  1.00 96.36  ?  424 LYS A N   1 
ATOM   1977 C CA  . LYS A 1 443 ? 19.999  31.623  65.642  1.00 93.35  ?  424 LYS A CA  1 
ATOM   1978 C C   . LYS A 1 443 ? 20.839  30.498  66.235  1.00 96.98  ?  424 LYS A C   1 
ATOM   1979 O O   . LYS A 1 443 ? 21.340  29.641  65.503  1.00 99.63  ?  424 LYS A O   1 
ATOM   1980 C CB  . LYS A 1 443 ? 20.823  32.908  65.519  1.00 89.66  ?  424 LYS A CB  1 
ATOM   1981 C CG  . LYS A 1 443 ? 20.068  34.040  64.849  1.00 91.86  ?  424 LYS A CG  1 
ATOM   1982 C CD  . LYS A 1 443 ? 20.878  35.321  64.726  1.00 94.98  ?  424 LYS A CD  1 
ATOM   1983 C CE  . LYS A 1 443 ? 19.960  36.465  64.314  1.00 100.74 ?  424 LYS A CE  1 
ATOM   1984 N NZ  . LYS A 1 443 ? 19.361  36.256  62.962  1.00 97.60  ?  424 LYS A NZ  1 
ATOM   1985 N N   . ASP A 1 444 ? 21.002  30.481  67.562  1.00 96.81  ?  425 ASP A N   1 
ATOM   1986 C CA  . ASP A 1 444 ? 21.716  29.377  68.206  1.00 99.49  ?  425 ASP A CA  1 
ATOM   1987 C C   . ASP A 1 444 ? 21.132  28.021  67.820  1.00 99.35  ?  425 ASP A C   1 
ATOM   1988 O O   . ASP A 1 444 ? 21.873  27.043  67.665  1.00 97.63  ?  425 ASP A O   1 
ATOM   1989 C CB  . ASP A 1 444 ? 21.698  29.516  69.733  1.00 99.60  ?  425 ASP A CB  1 
ATOM   1990 C CG  . ASP A 1 444 ? 22.901  30.278  70.267  1.00 109.42 ?  425 ASP A CG  1 
ATOM   1991 O OD1 . ASP A 1 444 ? 22.916  30.629  71.477  1.00 114.78 ?  425 ASP A OD1 1 
ATOM   1992 O OD2 . ASP A 1 444 ? 23.819  30.547  69.467  1.00 111.50 ?  425 ASP A OD2 1 
ATOM   1993 N N   . GLU A 1 445 ? 19.801  27.935  67.680  1.00 101.09 ?  426 GLU A N   1 
ATOM   1994 C CA  . GLU A 1 445 ? 19.171  26.651  67.373  1.00 100.73 ?  426 GLU A CA  1 
ATOM   1995 C C   . GLU A 1 445 ? 19.458  26.238  65.939  1.00 99.57  ?  426 GLU A C   1 
ATOM   1996 O O   . GLU A 1 445 ? 19.774  25.073  65.669  1.00 100.52 ?  426 GLU A O   1 
ATOM   1997 C CB  . GLU A 1 445 ? 17.655  26.691  67.610  1.00 96.99  ?  426 GLU A CB  1 
ATOM   1998 C CG  . GLU A 1 445 ? 17.130  26.459  69.049  1.00 97.40  ?  426 GLU A CG  1 
ATOM   1999 C CD  . GLU A 1 445 ? 17.667  25.213  69.779  1.00 105.92 ?  426 GLU A CD  1 
ATOM   2000 O OE1 . GLU A 1 445 ? 18.503  24.461  69.241  1.00 117.87 ?  426 GLU A OE1 1 
ATOM   2001 O OE2 . GLU A 1 445 ? 17.215  24.953  70.916  1.00 108.36 ?  426 GLU A OE2 1 
ATOM   2002 N N   . GLN A 1 446 ? 19.340  27.179  65.004  1.00 99.46  ?  427 GLN A N   1 
ATOM   2003 C CA  . GLN A 1 446 ? 19.679  26.879  63.619  1.00 101.49 ?  427 GLN A CA  1 
ATOM   2004 C C   . GLN A 1 446 ? 21.125  26.388  63.486  1.00 99.69  ?  427 GLN A C   1 
ATOM   2005 O O   . GLN A 1 446 ? 21.378  25.372  62.835  1.00 98.39  ?  427 GLN A O   1 
ATOM   2006 C CB  . GLN A 1 446 ? 19.410  28.103  62.749  1.00 98.55  ?  427 GLN A CB  1 
ATOM   2007 C CG  . GLN A 1 446 ? 18.043  28.092  62.115  1.00 99.34  ?  427 GLN A CG  1 
ATOM   2008 C CD  . GLN A 1 446 ? 17.603  29.489  61.761  1.00 110.48 ?  427 GLN A CD  1 
ATOM   2009 O OE1 . GLN A 1 446 ? 18.431  30.358  61.488  1.00 108.28 ?  427 GLN A OE1 1 
ATOM   2010 N NE2 . GLN A 1 446 ? 16.296  29.724  61.772  1.00 116.83 ?  427 GLN A NE2 1 
ATOM   2011 N N   . ILE A 1 447 ? 22.086  27.066  64.126  1.00 100.27 ?  428 ILE A N   1 
ATOM   2012 C CA  . ILE A 1 447 ? 23.482  26.626  64.026  1.00 97.64  ?  428 ILE A CA  1 
ATOM   2013 C C   . ILE A 1 447 ? 23.649  25.183  64.513  1.00 97.14  ?  428 ILE A C   1 
ATOM   2014 O O   . ILE A 1 447 ? 24.224  24.344  63.815  1.00 99.89  ?  428 ILE A O   1 
ATOM   2015 C CB  . ILE A 1 447 ? 24.426  27.581  64.781  1.00 95.70  ?  428 ILE A CB  1 
ATOM   2016 C CG1 . ILE A 1 447 ? 24.498  28.953  64.118  1.00 93.94  ?  428 ILE A CG1 1 
ATOM   2017 C CG2 . ILE A 1 447 ? 25.803  26.970  64.875  1.00 99.48  ?  428 ILE A CG2 1 
ATOM   2018 C CD1 . ILE A 1 447 ? 25.211  29.965  64.974  1.00 101.66 ?  428 ILE A CD1 1 
ATOM   2019 N N   . GLU A 1 448 ? 23.168  24.869  65.715  1.00 98.78  ?  429 GLU A N   1 
ATOM   2020 C CA  . GLU A 1 448 ? 23.231  23.489  66.214  1.00 98.45  ?  429 GLU A CA  1 
ATOM   2021 C C   . GLU A 1 448 ? 22.460  22.467  65.372  1.00 97.17  ?  429 GLU A C   1 
ATOM   2022 O O   . GLU A 1 448 ? 22.832  21.288  65.367  1.00 95.83  ?  429 GLU A O   1 
ATOM   2023 C CB  . GLU A 1 448 ? 22.802  23.460  67.683  1.00 96.16  ?  429 GLU A CB  1 
ATOM   2024 C CG  . GLU A 1 448 ? 22.435  22.056  68.205  1.00 107.86 ?  429 GLU A CG  1 
ATOM   2025 C CD  . GLU A 1 448 ? 22.308  21.980  69.660  1.00 117.56 ?  429 GLU A CD  1 
ATOM   2026 O OE1 . GLU A 1 448 ? 22.737  22.933  70.272  1.00 118.18 ?  429 GLU A OE1 1 
ATOM   2027 O OE2 . GLU A 1 448 ? 21.674  21.046  70.190  1.00 126.39 ?  429 GLU A OE2 1 
ATOM   2028 N N   . HIS A 1 449 ? 21.516  22.900  64.547  1.00 95.19  ?  430 HIS A N   1 
ATOM   2029 C CA  . HIS A 1 449 ? 20.835  21.979  63.642  1.00 94.22  ?  430 HIS A CA  1 
ATOM   2030 C C   . HIS A 1 449 ? 21.711  21.615  62.454  1.00 100.06 ?  430 HIS A C   1 
ATOM   2031 O O   . HIS A 1 449 ? 22.082  20.449  62.297  1.00 104.12 ?  430 HIS A O   1 
ATOM   2032 C CB  . HIS A 1 449 ? 19.529  22.587  63.129  1.00 97.81  ?  430 HIS A CB  1 
ATOM   2033 C CG  . HIS A 1 449 ? 18.793  21.741  62.128  1.00 99.70  ?  430 HIS A CG  1 
ATOM   2034 N ND1 . HIS A 1 449 ? 18.715  22.083  60.792  1.00 99.79  ?  430 HIS A ND1 1 
ATOM   2035 C CD2 . HIS A 1 449 ? 18.044  20.619  62.273  1.00 100.57 ?  430 HIS A CD2 1 
ATOM   2036 C CE1 . HIS A 1 449 ? 17.973  21.197  60.153  1.00 102.38 ?  430 HIS A CE1 1 
ATOM   2037 N NE2 . HIS A 1 449 ? 17.556  20.298  61.028  1.00 106.44 ?  430 HIS A NE2 1 
ATOM   2038 N N   . TRP A 1 450 ? 22.054  22.600  61.610  1.00 98.28  ?  431 TRP A N   1 
ATOM   2039 C CA  . TRP A 1 450 ? 22.934  22.315  60.480  1.00 95.56  ?  431 TRP A CA  1 
ATOM   2040 C C   . TRP A 1 450 ? 24.290  21.788  60.926  1.00 97.67  ?  431 TRP A C   1 
ATOM   2041 O O   . TRP A 1 450 ? 24.938  21.063  60.171  1.00 105.73 ?  431 TRP A O   1 
ATOM   2042 C CB  . TRP A 1 450 ? 23.139  23.544  59.604  1.00 94.99  ?  431 TRP A CB  1 
ATOM   2043 C CG  . TRP A 1 450 ? 21.902  24.267  59.230  1.00 100.74 ?  431 TRP A CG  1 
ATOM   2044 C CD1 . TRP A 1 450 ? 21.364  25.342  59.866  1.00 103.36 ?  431 TRP A CD1 1 
ATOM   2045 C CD2 . TRP A 1 450 ? 21.051  23.999  58.107  1.00 105.24 ?  431 TRP A CD2 1 
ATOM   2046 N NE1 . TRP A 1 450 ? 20.227  25.760  59.219  1.00 102.86 ?  431 TRP A NE1 1 
ATOM   2047 C CE2 . TRP A 1 450 ? 20.011  24.951  58.137  1.00 104.81 ?  431 TRP A CE2 1 
ATOM   2048 C CE3 . TRP A 1 450 ? 21.067  23.047  57.080  1.00 100.67 ?  431 TRP A CE3 1 
ATOM   2049 C CZ2 . TRP A 1 450 ? 18.991  24.975  57.189  1.00 110.97 ?  431 TRP A CZ2 1 
ATOM   2050 C CZ3 . TRP A 1 450 ? 20.050  23.075  56.134  1.00 106.85 ?  431 TRP A CZ3 1 
ATOM   2051 C CH2 . TRP A 1 450 ? 19.028  24.032  56.196  1.00 112.73 ?  431 TRP A CH2 1 
ATOM   2052 N N   . LYS A 1 451 ? 24.742  22.133  62.133  1.00 95.55  ?  432 LYS A N   1 
ATOM   2053 C CA  . LYS A 1 451 ? 25.957  21.511  62.646  1.00 96.58  ?  432 LYS A CA  1 
ATOM   2054 C C   . LYS A 1 451 ? 25.769  20.015  62.867  1.00 101.48 ?  432 LYS A C   1 
ATOM   2055 O O   . LYS A 1 451 ? 26.753  19.271  62.893  1.00 102.95 ?  432 LYS A O   1 
ATOM   2056 C CB  . LYS A 1 451 ? 26.421  22.191  63.937  1.00 94.18  ?  432 LYS A CB  1 
ATOM   2057 C CG  . LYS A 1 451 ? 27.587  23.140  63.686  1.00 99.88  ?  432 LYS A CG  1 
ATOM   2058 C CD  . LYS A 1 451 ? 28.460  23.362  64.907  1.00 106.99 ?  432 LYS A CD  1 
ATOM   2059 C CE  . LYS A 1 451 ? 29.430  24.526  64.671  1.00 112.28 ?  432 LYS A CE  1 
ATOM   2060 N NZ  . LYS A 1 451 ? 30.239  24.861  65.884  1.00 117.85 ?  432 LYS A NZ  1 
ATOM   2061 N N   . LYS A 1 452 ? 24.531  19.556  63.029  1.00 101.65 ?  433 LYS A N   1 
ATOM   2062 C CA  . LYS A 1 452 ? 24.291  18.125  62.976  1.00 97.57  ?  433 LYS A CA  1 
ATOM   2063 C C   . LYS A 1 452 ? 24.305  17.625  61.544  1.00 100.03 ?  433 LYS A C   1 
ATOM   2064 O O   . LYS A 1 452 ? 24.761  16.508  61.294  1.00 106.04 ?  433 LYS A O   1 
ATOM   2065 C CB  . LYS A 1 452 ? 22.960  17.768  63.644  1.00 100.06 ?  433 LYS A CB  1 
ATOM   2066 C CG  . LYS A 1 452 ? 22.986  17.869  65.152  1.00 104.94 ?  433 LYS A CG  1 
ATOM   2067 C CD  . LYS A 1 452 ? 21.755  17.253  65.791  1.00 109.52 ?  433 LYS A CD  1 
ATOM   2068 C CE  . LYS A 1 452 ? 21.464  17.906  67.141  1.00 113.34 ?  433 LYS A CE  1 
ATOM   2069 N NZ  . LYS A 1 452 ? 20.393  17.191  67.889  1.00 121.68 ?  433 LYS A NZ  1 
ATOM   2070 N N   . ILE A 1 453 ? 23.831  18.421  60.587  1.00 96.94  ?  434 ILE A N   1 
ATOM   2071 C CA  . ILE A 1 453 ? 23.859  17.937  59.215  1.00 99.45  ?  434 ILE A CA  1 
ATOM   2072 C C   . ILE A 1 453 ? 25.295  17.791  58.710  1.00 101.85 ?  434 ILE A C   1 
ATOM   2073 O O   . ILE A 1 453 ? 25.629  16.785  58.082  1.00 107.14 ?  434 ILE A O   1 
ATOM   2074 C CB  . ILE A 1 453 ? 22.986  18.803  58.292  1.00 98.11  ?  434 ILE A CB  1 
ATOM   2075 C CG1 . ILE A 1 453 ? 21.514  18.647  58.684  1.00 98.51  ?  434 ILE A CG1 1 
ATOM   2076 C CG2 . ILE A 1 453 ? 23.168  18.378  56.846  1.00 99.08  ?  434 ILE A CG2 1 
ATOM   2077 C CD1 . ILE A 1 453 ? 20.575  19.579  57.966  1.00 97.52  ?  434 ILE A CD1 1 
ATOM   2078 N N   . VAL A 1 454 ? 26.185  18.741  59.001  1.00 100.46 ?  435 VAL A N   1 
ATOM   2079 C CA  . VAL A 1 454 ? 27.593  18.499  58.675  1.00 99.44  ?  435 VAL A CA  1 
ATOM   2080 C C   . VAL A 1 454 ? 28.139  17.285  59.435  1.00 102.96 ?  435 VAL A C   1 
ATOM   2081 O O   . VAL A 1 454 ? 28.829  16.445  58.854  1.00 111.85 ?  435 VAL A O   1 
ATOM   2082 C CB  . VAL A 1 454 ? 28.469  19.750  58.901  1.00 99.31  ?  435 VAL A CB  1 
ATOM   2083 C CG1 . VAL A 1 454 ? 28.189  20.813  57.900  1.00 96.71  ?  435 VAL A CG1 1 
ATOM   2084 C CG2 . VAL A 1 454 ? 28.255  20.306  60.282  1.00 102.75 ?  435 VAL A CG2 1 
ATOM   2085 N N   . LYS A 1 455 ? 27.848  17.158  60.734  1.00 104.99 ?  436 LYS A N   1 
ATOM   2086 C CA  . LYS A 1 455 ? 28.454  16.044  61.472  1.00 105.22 ?  436 LYS A CA  1 
ATOM   2087 C C   . LYS A 1 455 ? 28.055  14.682  60.905  1.00 110.45 ?  436 LYS A C   1 
ATOM   2088 O O   . LYS A 1 455 ? 28.681  13.669  61.251  1.00 114.19 ?  436 LYS A O   1 
ATOM   2089 C CB  . LYS A 1 455 ? 28.100  16.095  62.965  1.00 100.95 ?  436 LYS A CB  1 
ATOM   2090 C CG  . LYS A 1 455 ? 29.124  15.400  63.891  1.00 102.66 ?  436 LYS A CG  1 
ATOM   2091 C CD  . LYS A 1 455 ? 28.470  14.837  65.166  1.00 110.70 ?  436 LYS A CD  1 
ATOM   2092 C CE  . LYS A 1 455 ? 29.491  14.234  66.145  1.00 112.54 ?  436 LYS A CE  1 
ATOM   2093 N NZ  . LYS A 1 455 ? 28.857  13.371  67.204  1.00 120.37 ?  436 LYS A NZ  1 
ATOM   2094 N N   . THR A 1 456 ? 27.043  14.631  60.040  1.00 104.63 ?  437 THR A N   1 
ATOM   2095 C CA  . THR A 1 456 ? 26.657  13.394  59.380  1.00 107.38 ?  437 THR A CA  1 
ATOM   2096 C C   . THR A 1 456 ? 27.034  13.359  57.906  1.00 105.91 ?  437 THR A C   1 
ATOM   2097 O O   . THR A 1 456 ? 27.356  12.288  57.398  1.00 110.14 ?  437 THR A O   1 
ATOM   2098 C CB  . THR A 1 456 ? 25.148  13.169  59.505  1.00 106.22 ?  437 THR A CB  1 
ATOM   2099 O OG1 . THR A 1 456 ? 24.480  14.236  58.845  1.00 111.05 ?  437 THR A OG1 1 
ATOM   2100 C CG2 . THR A 1 456 ? 24.731  13.131  60.968  1.00 106.07 ?  437 THR A CG2 1 
ATOM   2101 N N   . GLN A 1 457 ? 26.997  14.498  57.205  1.00 103.37 ?  438 GLN A N   1 
ATOM   2102 C CA  . GLN A 1 457 ? 27.531  14.556  55.847  1.00 100.31 ?  438 GLN A CA  1 
ATOM   2103 C C   . GLN A 1 457 ? 28.995  14.163  55.819  1.00 104.07 ?  438 GLN A C   1 
ATOM   2104 O O   . GLN A 1 457 ? 29.470  13.603  54.827  1.00 111.79 ?  438 GLN A O   1 
ATOM   2105 C CB  . GLN A 1 457 ? 27.368  15.955  55.268  1.00 97.48  ?  438 GLN A CB  1 
ATOM   2106 C CG  . GLN A 1 457 ? 25.939  16.320  54.968  1.00 99.09  ?  438 GLN A CG  1 
ATOM   2107 C CD  . GLN A 1 457 ? 25.465  15.810  53.643  1.00 96.80  ?  438 GLN A CD  1 
ATOM   2108 O OE1 . GLN A 1 457 ? 24.863  14.759  53.551  1.00 102.13 ?  438 GLN A OE1 1 
ATOM   2109 N NE2 . GLN A 1 457 ? 25.666  16.602  52.611  1.00 102.48 ?  438 GLN A NE2 1 
ATOM   2110 N N   . GLU A 1 458 ? 29.726  14.448  56.888  1.00 102.30 ?  439 GLU A N   1 
ATOM   2111 C CA  . GLU A 1 458 ? 31.129  14.077  56.930  1.00 106.47 ?  439 GLU A CA  1 
ATOM   2112 C C   . GLU A 1 458 ? 31.322  12.637  57.358  1.00 107.56 ?  439 GLU A C   1 
ATOM   2113 O O   . GLU A 1 458 ? 32.262  11.992  56.894  1.00 111.60 ?  439 GLU A O   1 
ATOM   2114 C CB  . GLU A 1 458 ? 31.905  15.009  57.860  1.00 114.80 ?  439 GLU A CB  1 
ATOM   2115 C CG  . GLU A 1 458 ? 32.217  16.361  57.226  1.00 116.24 ?  439 GLU A CG  1 
ATOM   2116 C CD  . GLU A 1 458 ? 33.278  17.139  57.985  1.00 124.95 ?  439 GLU A CD  1 
ATOM   2117 O OE1 . GLU A 1 458 ? 33.806  16.616  58.998  1.00 128.08 ?  439 GLU A OE1 1 
ATOM   2118 O OE2 . GLU A 1 458 ? 33.587  18.274  57.557  1.00 126.59 ?  439 GLU A OE2 1 
ATOM   2119 N N   . GLU A 1 459 ? 30.466  12.119  58.242  1.00 111.27 ?  440 GLU A N   1 
ATOM   2120 C CA  . GLU A 1 459 ? 30.465  10.683  58.486  1.00 107.98 ?  440 GLU A CA  1 
ATOM   2121 C C   . GLU A 1 459 ? 30.123  9.920   57.209  1.00 106.96 ?  440 GLU A C   1 
ATOM   2122 O O   . GLU A 1 459 ? 30.603  8.800   57.006  1.00 107.81 ?  440 GLU A O   1 
ATOM   2123 C CB  . GLU A 1 459 ? 29.493  10.341  59.621  1.00 106.28 ?  440 GLU A CB  1 
ATOM   2124 C CG  . GLU A 1 459 ? 29.785  9.006   60.317  1.00 119.65 ?  440 GLU A CG  1 
ATOM   2125 C CD  . GLU A 1 459 ? 28.990  8.797   61.611  1.00 129.45 ?  440 GLU A CD  1 
ATOM   2126 O OE1 . GLU A 1 459 ? 28.044  9.573   61.875  1.00 128.46 ?  440 GLU A OE1 1 
ATOM   2127 O OE2 . GLU A 1 459 ? 29.319  7.852   62.370  1.00 133.47 ?  440 GLU A OE2 1 
ATOM   2128 N N   . LEU A 1 460 ? 29.323  10.526  56.327  1.00 102.55 ?  441 LEU A N   1 
ATOM   2129 C CA  . LEU A 1 460 ? 29.039  9.935   55.023  1.00 103.29 ?  441 LEU A CA  1 
ATOM   2130 C C   . LEU A 1 460 ? 30.239  10.051  54.088  1.00 106.29 ?  441 LEU A C   1 
ATOM   2131 O O   . LEU A 1 460 ? 30.584  9.091   53.390  1.00 104.91 ?  441 LEU A O   1 
ATOM   2132 C CB  . LEU A 1 460 ? 27.823  10.619  54.401  1.00 100.61 ?  441 LEU A CB  1 
ATOM   2133 C CG  . LEU A 1 460 ? 27.199  9.962   53.173  1.00 102.56 ?  441 LEU A CG  1 
ATOM   2134 C CD1 . LEU A 1 460 ? 26.610  8.615   53.554  1.00 103.67 ?  441 LEU A CD1 1 
ATOM   2135 C CD2 . LEU A 1 460 ? 26.149  10.862  52.543  1.00 98.62  ?  441 LEU A CD2 1 
ATOM   2136 N N   . LYS A 1 461 ? 30.866  11.229  54.043  1.00 106.39 ?  442 LYS A N   1 
ATOM   2137 C CA  . LYS A 1 461 ? 32.067  11.413  53.234  1.00 104.78 ?  442 LYS A CA  1 
ATOM   2138 C C   . LYS A 1 461 ? 33.111  10.351  53.562  1.00 105.14 ?  442 LYS A C   1 
ATOM   2139 O O   . LYS A 1 461 ? 33.630  9.682   52.665  1.00 111.26 ?  442 LYS A O   1 
ATOM   2140 C CB  . LYS A 1 461 ? 32.627  12.829  53.439  1.00 102.66 ?  442 LYS A CB  1 
ATOM   2141 C CG  . LYS A 1 461 ? 33.997  13.087  52.822  1.00 100.65 ?  442 LYS A CG  1 
ATOM   2142 C CD  . LYS A 1 461 ? 34.098  14.474  52.196  1.00 99.06  ?  442 LYS A CD  1 
ATOM   2143 C CE  . LYS A 1 461 ? 35.549  14.965  52.130  1.00 106.12 ?  442 LYS A CE  1 
ATOM   2144 N NZ  . LYS A 1 461 ? 35.669  16.456  52.002  1.00 110.45 ?  442 LYS A NZ  1 
ATOM   2145 N N   . GLU A 1 462 ? 33.419  10.163  54.847  1.00 101.95 ?  443 GLU A N   1 
ATOM   2146 C CA  . GLU A 1 462 ? 34.366  9.117   55.212  1.00 105.41 ?  443 GLU A CA  1 
ATOM   2147 C C   . GLU A 1 462 ? 33.849  7.750   54.818  1.00 106.24 ?  443 GLU A C   1 
ATOM   2148 O O   . GLU A 1 462 ? 34.635  6.847   54.512  1.00 108.72 ?  443 GLU A O   1 
ATOM   2149 C CB  . GLU A 1 462 ? 34.666  9.141   56.712  1.00 108.10 ?  443 GLU A CB  1 
ATOM   2150 C CG  . GLU A 1 462 ? 35.907  9.936   57.084  1.00 116.76 ?  443 GLU A CG  1 
ATOM   2151 C CD  . GLU A 1 462 ? 36.187  9.917   58.580  1.00 132.67 ?  443 GLU A CD  1 
ATOM   2152 O OE1 . GLU A 1 462 ? 36.153  8.814   59.181  1.00 124.36 ?  443 GLU A OE1 1 
ATOM   2153 O OE2 . GLU A 1 462 ? 36.437  11.007  59.153  1.00 140.59 ?  443 GLU A OE2 1 
ATOM   2154 N N   . LEU A 1 463 ? 32.537  7.574   54.813  1.00 105.08 ?  444 LEU A N   1 
ATOM   2155 C CA  . LEU A 1 463 ? 32.005  6.276   54.451  1.00 102.02 ?  444 LEU A CA  1 
ATOM   2156 C C   . LEU A 1 463 ? 32.089  6.022   52.952  1.00 104.50 ?  444 LEU A C   1 
ATOM   2157 O O   . LEU A 1 463 ? 32.260  4.876   52.537  1.00 105.10 ?  444 LEU A O   1 
ATOM   2158 C CB  . LEU A 1 463 ? 30.558  6.158   54.889  1.00 101.62 ?  444 LEU A CB  1 
ATOM   2159 C CG  . LEU A 1 463 ? 30.111  4.717   54.851  1.00 99.27  ?  444 LEU A CG  1 
ATOM   2160 C CD1 . LEU A 1 463 ? 30.694  4.042   56.083  1.00 101.16 ?  444 LEU A CD1 1 
ATOM   2161 C CD2 . LEU A 1 463 ? 28.606  4.643   54.801  1.00 99.89  ?  444 LEU A CD2 1 
ATOM   2162 N N   . LEU A 1 464 ? 31.958  7.047   52.116  1.00 103.94 ?  445 LEU A N   1 
ATOM   2163 C CA  . LEU A 1 464 ? 31.966  6.745   50.693  1.00 102.33 ?  445 LEU A CA  1 
ATOM   2164 C C   . LEU A 1 464 ? 33.394  6.629   50.179  1.00 103.35 ?  445 LEU A C   1 
ATOM   2165 O O   . LEU A 1 464 ? 33.669  5.825   49.282  1.00 105.75 ?  445 LEU A O   1 
ATOM   2166 C CB  . LEU A 1 464 ? 31.193  7.796   49.907  1.00 102.43 ?  445 LEU A CB  1 
ATOM   2167 C CG  . LEU A 1 464 ? 29.734  7.990   50.331  1.00 103.85 ?  445 LEU A CG  1 
ATOM   2168 C CD1 . LEU A 1 464 ? 29.016  9.015   49.437  1.00 105.30 ?  445 LEU A CD1 1 
ATOM   2169 C CD2 . LEU A 1 464 ? 28.953  6.689   50.529  1.00 97.78  ?  445 LEU A CD2 1 
ATOM   2170 N N   . ASN A 1 465 ? 34.321  7.403   50.746  1.00 102.02 ?  446 ASN A N   1 
ATOM   2171 C CA  . ASN A 1 465 ? 35.728  7.172   50.453  1.00 104.27 ?  446 ASN A CA  1 
ATOM   2172 C C   . ASN A 1 465 ? 36.132  5.757   50.811  1.00 105.78 ?  446 ASN A C   1 
ATOM   2173 O O   . ASN A 1 465 ? 37.049  5.193   50.202  1.00 107.28 ?  446 ASN A O   1 
ATOM   2174 C CB  . ASN A 1 465 ? 36.601  8.203   51.168  1.00 99.33  ?  446 ASN A CB  1 
ATOM   2175 C CG  . ASN A 1 465 ? 36.819  9.442   50.318  1.00 102.75 ?  446 ASN A CG  1 
ATOM   2176 O OD1 . ASN A 1 465 ? 36.169  10.466  50.500  1.00 109.70 ?  446 ASN A OD1 1 
ATOM   2177 N ND2 . ASN A 1 465 ? 37.770  9.358   49.398  1.00 104.52 ?  446 ASN A ND2 1 
ATOM   2178 N N   . LYS A 1 466 ? 35.430  5.140   51.745  1.00 102.10 ?  447 LYS A N   1 
ATOM   2179 C CA  . LYS A 1 466 ? 35.784  3.768   52.023  1.00 102.18 ?  447 LYS A CA  1 
ATOM   2180 C C   . LYS A 1 466 ? 35.208  2.819   50.981  1.00 103.18 ?  447 LYS A C   1 
ATOM   2181 O O   . LYS A 1 466 ? 35.872  1.856   50.598  1.00 104.96 ?  447 LYS A O   1 
ATOM   2182 C CB  . LYS A 1 466 ? 35.326  3.419   53.420  1.00 105.86 ?  447 LYS A CB  1 
ATOM   2183 C CG  . LYS A 1 466 ? 35.871  2.139   53.905  1.00 109.99 ?  447 LYS A CG  1 
ATOM   2184 C CD  . LYS A 1 466 ? 35.542  2.073   55.361  1.00 107.41 ?  447 LYS A CD  1 
ATOM   2185 C CE  . LYS A 1 466 ? 36.200  3.330   55.957  1.00 113.35 ?  447 LYS A CE  1 
ATOM   2186 N NZ  . LYS A 1 466 ? 37.672  3.431   55.697  1.00 119.13 ?  447 LYS A NZ  1 
ATOM   2187 N N   . MET A 1 467 ? 34.018  3.091   50.475  1.00 98.78  ?  448 MET A N   1 
ATOM   2188 C CA  . MET A 1 467 ? 33.410  2.264   49.450  1.00 101.12 ?  448 MET A CA  1 
ATOM   2189 C C   . MET A 1 467 ? 33.907  2.538   48.035  1.00 101.63 ?  448 MET A C   1 
ATOM   2190 O O   . MET A 1 467 ? 33.572  1.774   47.123  1.00 101.89 ?  448 MET A O   1 
ATOM   2191 C CB  . MET A 1 467 ? 31.926  2.527   49.526  1.00 101.90 ?  448 MET A CB  1 
ATOM   2192 C CG  . MET A 1 467 ? 31.310  2.016   50.814  1.00 105.94 ?  448 MET A CG  1 
ATOM   2193 S SD  . MET A 1 467 ? 29.597  2.604   50.947  1.00 113.50 ?  448 MET A SD  1 
ATOM   2194 C CE  . MET A 1 467 ? 28.737  2.002   49.447  1.00 104.24 ?  448 MET A CE  1 
ATOM   2195 N N   . VAL A 1 468 ? 34.657  3.612   47.809  1.00 100.35 ?  449 VAL A N   1 
ATOM   2196 C CA  . VAL A 1 468 ? 35.438  3.686   46.580  1.00 100.34 ?  449 VAL A CA  1 
ATOM   2197 C C   . VAL A 1 468 ? 36.666  2.797   46.698  1.00 105.34 ?  449 VAL A C   1 
ATOM   2198 O O   . VAL A 1 468 ? 36.850  1.863   45.910  1.00 107.94 ?  449 VAL A O   1 
ATOM   2199 C CB  . VAL A 1 468 ? 35.839  5.135   46.241  1.00 97.86  ?  449 VAL A CB  1 
ATOM   2200 C CG1 . VAL A 1 468 ? 37.009  5.149   45.242  1.00 99.65  ?  449 VAL A CG1 1 
ATOM   2201 C CG2 . VAL A 1 468 ? 34.693  5.898   45.629  1.00 95.48  ?  449 VAL A CG2 1 
ATOM   2202 N N   . ASN A 1 469 ? 37.508  3.063   47.703  1.00 103.96 ?  450 ASN A N   1 
ATOM   2203 C CA  . ASN A 1 469 ? 38.759  2.331   47.863  1.00 104.24 ?  450 ASN A CA  1 
ATOM   2204 C C   . ASN A 1 469 ? 38.529  0.844   48.090  1.00 107.93 ?  450 ASN A C   1 
ATOM   2205 O O   . ASN A 1 469 ? 39.467  0.047   47.962  1.00 109.30 ?  450 ASN A O   1 
ATOM   2206 C CB  . ASN A 1 469 ? 39.574  2.924   49.017  1.00 102.47 ?  450 ASN A CB  1 
ATOM   2207 C CG  . ASN A 1 469 ? 40.240  4.257   48.648  1.00 112.11 ?  450 ASN A CG  1 
ATOM   2208 O OD1 . ASN A 1 469 ? 39.621  5.133   48.034  1.00 113.33 ?  450 ASN A OD1 1 
ATOM   2209 N ND2 . ASN A 1 469 ? 41.507  4.416   49.036  1.00 113.84 ?  450 ASN A ND2 1 
ATOM   2210 N N   . LEU A 1 470 ? 37.309  0.449   48.424  1.00 105.65 ?  451 LEU A N   1 
ATOM   2211 C CA  . LEU A 1 470 ? 37.030  -0.964  48.599  1.00 103.36 ?  451 LEU A CA  1 
ATOM   2212 C C   . LEU A 1 470 ? 36.459  -1.571  47.327  1.00 100.96 ?  451 LEU A C   1 
ATOM   2213 O O   . LEU A 1 470 ? 36.792  -2.708  46.983  1.00 99.67  ?  451 LEU A O   1 
ATOM   2214 C CB  . LEU A 1 470 ? 36.080  -1.154  49.775  1.00 97.64  ?  451 LEU A CB  1 
ATOM   2215 C CG  . LEU A 1 470 ? 35.573  -2.545  50.058  1.00 99.14  ?  451 LEU A CG  1 
ATOM   2216 C CD1 . LEU A 1 470 ? 36.567  -3.273  50.939  1.00 101.12 ?  451 LEU A CD1 1 
ATOM   2217 C CD2 . LEU A 1 470 ? 34.261  -2.379  50.754  1.00 99.90  ?  451 LEU A CD2 1 
ATOM   2218 N N   . LYS A 1 471 ? 35.618  -0.829  46.607  1.00 97.63  ?  452 LYS A N   1 
ATOM   2219 C CA  . LYS A 1 471 ? 35.203  -1.295  45.292  1.00 98.20  ?  452 LYS A CA  1 
ATOM   2220 C C   . LYS A 1 471 ? 36.393  -1.411  44.351  1.00 106.08 ?  452 LYS A C   1 
ATOM   2221 O O   . LYS A 1 471 ? 36.405  -2.278  43.472  1.00 109.03 ?  452 LYS A O   1 
ATOM   2222 C CB  . LYS A 1 471 ? 34.142  -0.370  44.698  1.00 94.97  ?  452 LYS A CB  1 
ATOM   2223 C CG  . LYS A 1 471 ? 33.841  -0.640  43.239  1.00 90.23  ?  452 LYS A CG  1 
ATOM   2224 C CD  . LYS A 1 471 ? 32.574  0.030   42.767  1.00 92.32  ?  452 LYS A CD  1 
ATOM   2225 C CE  . LYS A 1 471 ? 32.431  -0.100  41.265  1.00 102.00 ?  452 LYS A CE  1 
ATOM   2226 N NZ  . LYS A 1 471 ? 31.327  0.736   40.733  1.00 109.93 ?  452 LYS A NZ  1 
ATOM   2227 N N   . GLU A 1 472 ? 37.417  -0.579  44.526  1.00 105.22 ?  453 GLU A N   1 
ATOM   2228 C CA  . GLU A 1 472 ? 38.580  -0.732  43.665  1.00 99.45  ?  453 GLU A CA  1 
ATOM   2229 C C   . GLU A 1 472 ? 39.437  -1.929  44.056  1.00 102.92 ?  453 GLU A C   1 
ATOM   2230 O O   . GLU A 1 472 ? 40.134  -2.474  43.198  1.00 105.20 ?  453 GLU A O   1 
ATOM   2231 C CB  . GLU A 1 472 ? 39.410  0.543   43.655  1.00 101.56 ?  453 GLU A CB  1 
ATOM   2232 C CG  . GLU A 1 472 ? 38.638  1.738   43.104  1.00 114.65 ?  453 GLU A CG  1 
ATOM   2233 C CD  . GLU A 1 472 ? 38.154  1.536   41.658  1.00 126.77 ?  453 GLU A CD  1 
ATOM   2234 O OE1 . GLU A 1 472 ? 37.215  2.256   41.237  1.00 127.93 ?  453 GLU A OE1 1 
ATOM   2235 O OE2 . GLU A 1 472 ? 38.706  0.667   40.939  1.00 125.35 ?  453 GLU A OE2 1 
ATOM   2236 N N   . LYS A 1 473 ? 39.408  -2.362  45.323  1.00 101.58 ?  454 LYS A N   1 
ATOM   2237 C CA  . LYS A 1 473 ? 40.072  -3.617  45.676  1.00 101.23 ?  454 LYS A CA  1 
ATOM   2238 C C   . LYS A 1 473 ? 39.273  -4.809  45.169  1.00 100.20 ?  454 LYS A C   1 
ATOM   2239 O O   . LYS A 1 473 ? 39.843  -5.803  44.703  1.00 96.16  ?  454 LYS A O   1 
ATOM   2240 C CB  . LYS A 1 473 ? 40.279  -3.736  47.190  1.00 101.09 ?  454 LYS A CB  1 
ATOM   2241 C CG  . LYS A 1 473 ? 41.590  -3.149  47.715  1.00 106.05 ?  454 LYS A CG  1 
ATOM   2242 C CD  . LYS A 1 473 ? 41.706  -3.308  49.244  1.00 116.42 ?  454 LYS A CD  1 
ATOM   2243 C CE  . LYS A 1 473 ? 42.760  -2.373  49.864  1.00 120.88 ?  454 LYS A CE  1 
ATOM   2244 N NZ  . LYS A 1 473 ? 42.189  -1.056  50.303  1.00 120.08 ?  454 LYS A NZ  1 
ATOM   2245 N N   . ILE A 1 474 ? 37.949  -4.726  45.256  1.00 99.07  ?  455 ILE A N   1 
ATOM   2246 C CA  . ILE A 1 474 ? 37.117  -5.787  44.721  1.00 92.70  ?  455 ILE A CA  1 
ATOM   2247 C C   . ILE A 1 474 ? 37.227  -5.839  43.202  1.00 98.29  ?  455 ILE A C   1 
ATOM   2248 O O   . ILE A 1 474 ? 37.117  -6.910  42.604  1.00 96.06  ?  455 ILE A O   1 
ATOM   2249 C CB  . ILE A 1 474 ? 35.675  -5.577  45.198  1.00 92.56  ?  455 ILE A CB  1 
ATOM   2250 C CG1 . ILE A 1 474 ? 35.583  -5.924  46.685  1.00 95.57  ?  455 ILE A CG1 1 
ATOM   2251 C CG2 . ILE A 1 474 ? 34.700  -6.413  44.367  1.00 98.81  ?  455 ILE A CG2 1 
ATOM   2252 C CD1 . ILE A 1 474 ? 34.192  -5.880  47.222  1.00 101.64 ?  455 ILE A CD1 1 
ATOM   2253 N N   . LYS A 1 475 ? 37.474  -4.703  42.546  1.00 101.57 ?  456 LYS A N   1 
ATOM   2254 C CA  . LYS A 1 475 ? 37.632  -4.734  41.093  1.00 100.04 ?  456 LYS A CA  1 
ATOM   2255 C C   . LYS A 1 475 ? 38.953  -5.414  40.698  1.00 99.40  ?  456 LYS A C   1 
ATOM   2256 O O   . LYS A 1 475 ? 39.038  -6.098  39.667  1.00 93.36  ?  456 LYS A O   1 
ATOM   2257 C CB  . LYS A 1 475 ? 37.489  -3.305  40.534  1.00 99.44  ?  456 LYS A CB  1 
ATOM   2258 C CG  . LYS A 1 475 ? 37.445  -3.234  38.993  1.00 109.23 ?  456 LYS A CG  1 
ATOM   2259 C CD  . LYS A 1 475 ? 37.298  -1.823  38.316  1.00 120.17 ?  456 LYS A CD  1 
ATOM   2260 C CE  . LYS A 1 475 ? 35.864  -1.234  38.362  1.00 121.93 ?  456 LYS A CE  1 
ATOM   2261 N NZ  . LYS A 1 475 ? 35.609  0.027   37.587  1.00 120.58 ?  456 LYS A NZ  1 
ATOM   2262 N N   . GLU A 1 476 ? 39.968  -5.297  41.553  1.00 98.38  ?  457 GLU A N   1 
ATOM   2263 C CA  . GLU A 1 476 ? 41.273  -5.895  41.313  1.00 94.79  ?  457 GLU A CA  1 
ATOM   2264 C C   . GLU A 1 476 ? 41.278  -7.380  41.655  1.00 94.21  ?  457 GLU A C   1 
ATOM   2265 O O   . GLU A 1 476 ? 41.805  -8.192  40.890  1.00 93.90  ?  457 GLU A O   1 
ATOM   2266 C CB  . GLU A 1 476 ? 42.329  -5.163  42.139  1.00 93.66  ?  457 GLU A CB  1 
ATOM   2267 C CG  . GLU A 1 476 ? 43.746  -5.227  41.607  1.00 100.88 ?  457 GLU A CG  1 
ATOM   2268 C CD  . GLU A 1 476 ? 44.769  -4.800  42.653  1.00 110.92 ?  457 GLU A CD  1 
ATOM   2269 O OE1 . GLU A 1 476 ? 45.427  -3.753  42.447  1.00 117.20 ?  457 GLU A OE1 1 
ATOM   2270 O OE2 . GLU A 1 476 ? 44.923  -5.511  43.676  1.00 109.97 ?  457 GLU A OE2 1 
ATOM   2271 N N   . LEU A 1 477 ? 40.722  -7.748  42.815  1.00 95.42  ?  458 LEU A N   1 
ATOM   2272 C CA  . LEU A 1 477 ? 40.701  -9.152  43.218  1.00 90.00  ?  458 LEU A CA  1 
ATOM   2273 C C   . LEU A 1 477 ? 39.915  -9.998  42.239  1.00 92.86  ?  458 LEU A C   1 
ATOM   2274 O O   . LEU A 1 477 ? 40.283  -11.144 41.960  1.00 95.04  ?  458 LEU A O   1 
ATOM   2275 C CB  . LEU A 1 477 ? 40.096  -9.310  44.603  1.00 87.95  ?  458 LEU A CB  1 
ATOM   2276 C CG  . LEU A 1 477 ? 41.104  -9.413  45.724  1.00 93.86  ?  458 LEU A CG  1 
ATOM   2277 C CD1 . LEU A 1 477 ? 40.389  -9.800  47.015  1.00 97.74  ?  458 LEU A CD1 1 
ATOM   2278 C CD2 . LEU A 1 477 ? 42.141  -10.443 45.343  1.00 94.72  ?  458 LEU A CD2 1 
ATOM   2279 N N   . HIS A 1 478 ? 38.810  -9.466  41.735  1.00 90.00  ?  459 HIS A N   1 
ATOM   2280 C CA  . HIS A 1 478 ? 38.039  -10.194 40.744  1.00 89.29  ?  459 HIS A CA  1 
ATOM   2281 C C   . HIS A 1 478 ? 38.913  -10.551 39.552  1.00 94.94  ?  459 HIS A C   1 
ATOM   2282 O O   . HIS A 1 478 ? 38.952  -11.708 39.122  1.00 94.17  ?  459 HIS A O   1 
ATOM   2283 C CB  . HIS A 1 478 ? 36.849  -9.351  40.320  1.00 93.74  ?  459 HIS A CB  1 
ATOM   2284 C CG  . HIS A 1 478 ? 35.938  -10.032 39.360  1.00 93.58  ?  459 HIS A CG  1 
ATOM   2285 N ND1 . HIS A 1 478 ? 34.993  -10.952 39.762  1.00 93.33  ?  459 HIS A ND1 1 
ATOM   2286 C CD2 . HIS A 1 478 ? 35.814  -9.919  38.016  1.00 90.91  ?  459 HIS A CD2 1 
ATOM   2287 C CE1 . HIS A 1 478 ? 34.324  -11.377 38.705  1.00 94.62  ?  459 HIS A CE1 1 
ATOM   2288 N NE2 . HIS A 1 478 ? 34.802  -10.767 37.634  1.00 95.27  ?  459 HIS A NE2 1 
ATOM   2289 N N   . GLN A 1 479 ? 39.645  -9.567  39.024  1.00 95.01  ?  460 GLN A N   1 
ATOM   2290 C CA  . GLN A 1 479 ? 40.570  -9.827  37.928  1.00 90.75  ?  460 GLN A CA  1 
ATOM   2291 C C   . GLN A 1 479 ? 41.518  -10.956 38.288  1.00 91.72  ?  460 GLN A C   1 
ATOM   2292 O O   . GLN A 1 479 ? 41.680  -11.920 37.530  1.00 94.73  ?  460 GLN A O   1 
ATOM   2293 C CB  . GLN A 1 479 ? 41.350  -8.555  37.578  1.00 87.18  ?  460 GLN A CB  1 
ATOM   2294 C CG  . GLN A 1 479 ? 42.084  -8.616  36.265  1.00 86.31  ?  460 GLN A CG  1 
ATOM   2295 C CD  . GLN A 1 479 ? 41.260  -9.277  35.162  1.00 100.69 ?  460 GLN A CD  1 
ATOM   2296 O OE1 . GLN A 1 479 ? 40.026  -9.168  35.132  1.00 97.54  ?  460 GLN A OE1 1 
ATOM   2297 N NE2 . GLN A 1 479 ? 41.942  -9.989  34.259  1.00 101.77 ?  460 GLN A NE2 1 
ATOM   2298 N N   . GLN A 1 480 ? 42.116  -10.873 39.471  1.00 85.97  ?  461 GLN A N   1 
ATOM   2299 C CA  . GLN A 1 480 ? 43.072  -11.885 39.891  1.00 89.12  ?  461 GLN A CA  1 
ATOM   2300 C C   . GLN A 1 480 ? 42.414  -13.263 40.034  1.00 91.78  ?  461 GLN A C   1 
ATOM   2301 O O   . GLN A 1 480 ? 43.014  -14.285 39.675  1.00 83.80  ?  461 GLN A O   1 
ATOM   2302 C CB  . GLN A 1 480 ? 43.737  -11.423 41.187  1.00 84.01  ?  461 GLN A CB  1 
ATOM   2303 C CG  . GLN A 1 480 ? 44.506  -10.128 40.996  1.00 84.13  ?  461 GLN A CG  1 
ATOM   2304 C CD  . GLN A 1 480 ? 45.267  -9.683  42.231  1.00 92.68  ?  461 GLN A CD  1 
ATOM   2305 O OE1 . GLN A 1 480 ? 45.268  -10.361 43.261  1.00 93.05  ?  461 GLN A OE1 1 
ATOM   2306 N NE2 . GLN A 1 480 ? 45.925  -8.528  42.131  1.00 98.46  ?  461 GLN A NE2 1 
ATOM   2307 N N   . TYR A 1 481 ? 41.179  -13.317 40.537  1.00 88.59  ?  462 TYR A N   1 
ATOM   2308 C CA  . TYR A 1 481 ? 40.513  -14.608 40.637  1.00 83.47  ?  462 TYR A CA  1 
ATOM   2309 C C   . TYR A 1 481 ? 40.123  -15.129 39.266  1.00 88.63  ?  462 TYR A C   1 
ATOM   2310 O O   . TYR A 1 481 ? 40.110  -16.346 39.044  1.00 91.57  ?  462 TYR A O   1 
ATOM   2311 C CB  . TYR A 1 481 ? 39.279  -14.514 41.525  1.00 83.88  ?  462 TYR A CB  1 
ATOM   2312 C CG  . TYR A 1 481 ? 38.317  -15.689 41.403  1.00 82.13  ?  462 TYR A CG  1 
ATOM   2313 C CD1 . TYR A 1 481 ? 37.296  -15.692 40.452  1.00 85.20  ?  462 TYR A CD1 1 
ATOM   2314 C CD2 . TYR A 1 481 ? 38.413  -16.788 42.262  1.00 85.84  ?  462 TYR A CD2 1 
ATOM   2315 C CE1 . TYR A 1 481 ? 36.409  -16.765 40.350  1.00 88.61  ?  462 TYR A CE1 1 
ATOM   2316 C CE2 . TYR A 1 481 ? 37.525  -17.864 42.173  1.00 84.55  ?  462 TYR A CE2 1 
ATOM   2317 C CZ  . TYR A 1 481 ? 36.528  -17.845 41.213  1.00 87.14  ?  462 TYR A CZ  1 
ATOM   2318 O OH  . TYR A 1 481 ? 35.650  -18.900 41.109  1.00 87.92  ?  462 TYR A OH  1 
ATOM   2319 N N   . LYS A 1 482 ? 39.755  -14.236 38.344  1.00 88.92  ?  463 LYS A N   1 
ATOM   2320 C CA  . LYS A 1 482 ? 39.387  -14.692 37.008  1.00 92.08  ?  463 LYS A CA  1 
ATOM   2321 C C   . LYS A 1 482 ? 40.590  -15.345 36.331  1.00 93.61  ?  463 LYS A C   1 
ATOM   2322 O O   . LYS A 1 482 ? 40.515  -16.498 35.891  1.00 83.82  ?  463 LYS A O   1 
ATOM   2323 C CB  . LYS A 1 482 ? 38.815  -13.527 36.184  1.00 87.20  ?  463 LYS A CB  1 
ATOM   2324 C CG  . LYS A 1 482 ? 37.542  -13.884 35.382  1.00 93.43  ?  463 LYS A CG  1 
ATOM   2325 C CD  . LYS A 1 482 ? 36.448  -14.546 36.267  1.00 98.66  ?  463 LYS A CD  1 
ATOM   2326 C CE  . LYS A 1 482 ? 35.047  -14.561 35.594  1.00 103.16 ?  463 LYS A CE  1 
ATOM   2327 N NZ  . LYS A 1 482 ? 33.974  -15.210 36.446  1.00 95.30  ?  463 LYS A NZ  1 
ATOM   2328 N N   . GLU A 1 483 ? 41.736  -14.646 36.330  1.00 89.98  ?  464 GLU A N   1 
ATOM   2329 C CA  . GLU A 1 483 ? 42.990  -15.212 35.842  1.00 85.30  ?  464 GLU A CA  1 
ATOM   2330 C C   . GLU A 1 483 ? 43.345  -16.539 36.518  1.00 87.30  ?  464 GLU A C   1 
ATOM   2331 O O   . GLU A 1 483 ? 43.880  -17.445 35.878  1.00 86.56  ?  464 GLU A O   1 
ATOM   2332 C CB  . GLU A 1 483 ? 44.124  -14.220 36.058  1.00 78.87  ?  464 GLU A CB  1 
ATOM   2333 C CG  . GLU A 1 483 ? 44.084  -13.029 35.150  1.00 96.34  ?  464 GLU A CG  1 
ATOM   2334 C CD  . GLU A 1 483 ? 44.987  -11.901 35.637  1.00 103.18 ?  464 GLU A CD  1 
ATOM   2335 O OE1 . GLU A 1 483 ? 45.832  -12.164 36.537  1.00 102.82 ?  464 GLU A OE1 1 
ATOM   2336 O OE2 . GLU A 1 483 ? 44.845  -10.764 35.116  1.00 98.77  ?  464 GLU A OE2 1 
ATOM   2337 N N   . ALA A 1 484 ? 43.108  -16.662 37.816  1.00 86.66  ?  465 ALA A N   1 
ATOM   2338 C CA  . ALA A 1 484 ? 43.515  -17.885 38.490  1.00 81.28  ?  465 ALA A CA  1 
ATOM   2339 C C   . ALA A 1 484 ? 42.567  -19.023 38.175  1.00 87.43  ?  465 ALA A C   1 
ATOM   2340 O O   . ALA A 1 484 ? 42.965  -20.189 38.211  1.00 85.23  ?  465 ALA A O   1 
ATOM   2341 C CB  . ALA A 1 484 ? 43.591  -17.672 39.995  1.00 82.21  ?  465 ALA A CB  1 
ATOM   2342 N N   . SER A 1 485 ? 41.317  -18.713 37.869  1.00 91.15  ?  466 SER A N   1 
ATOM   2343 C CA  . SER A 1 485 ? 40.404  -19.749 37.423  1.00 92.67  ?  466 SER A CA  1 
ATOM   2344 C C   . SER A 1 485 ? 40.586  -20.072 35.930  1.00 94.53  ?  466 SER A C   1 
ATOM   2345 O O   . SER A 1 485 ? 40.007  -21.051 35.443  1.00 93.32  ?  466 SER A O   1 
ATOM   2346 C CB  . SER A 1 485 ? 38.971  -19.304 37.758  1.00 92.94  ?  466 SER A CB  1 
ATOM   2347 O OG  . SER A 1 485 ? 38.029  -20.342 37.563  1.00 106.64 ?  466 SER A OG  1 
ATOM   2348 N N   . GLU A 1 486 ? 41.401  -19.283 35.206  1.00 95.11  ?  467 GLU A N   1 
ATOM   2349 C CA  . GLU A 1 486 ? 41.700  -19.502 33.791  1.00 91.62  ?  467 GLU A CA  1 
ATOM   2350 C C   . GLU A 1 486 ? 42.799  -20.545 33.589  1.00 93.44  ?  467 GLU A C   1 
ATOM   2351 O O   . GLU A 1 486 ? 43.092  -20.912 32.443  1.00 99.74  ?  467 GLU A O   1 
ATOM   2352 C CB  . GLU A 1 486 ? 42.161  -18.197 33.113  1.00 91.69  ?  467 GLU A CB  1 
ATOM   2353 C CG  . GLU A 1 486 ? 41.201  -17.006 33.109  1.00 106.06 ?  467 GLU A CG  1 
ATOM   2354 C CD  . GLU A 1 486 ? 40.345  -16.898 31.879  1.00 112.78 ?  467 GLU A CD  1 
ATOM   2355 O OE1 . GLU A 1 486 ? 40.920  -16.723 30.785  1.00 121.56 ?  467 GLU A OE1 1 
ATOM   2356 O OE2 . GLU A 1 486 ? 39.100  -16.937 32.014  1.00 114.23 ?  467 GLU A OE2 1 
ATOM   2357 N N   . VAL A 1 487 ? 43.457  -20.979 34.661  1.00 84.22  ?  468 VAL A N   1 
ATOM   2358 C CA  . VAL A 1 487 ? 44.493  -22.000 34.556  1.00 79.50  ?  468 VAL A CA  1 
ATOM   2359 C C   . VAL A 1 487 ? 43.804  -23.352 34.539  1.00 86.41  ?  468 VAL A C   1 
ATOM   2360 O O   . VAL A 1 487 ? 43.101  -23.710 35.488  1.00 89.83  ?  468 VAL A O   1 
ATOM   2361 C CB  . VAL A 1 487 ? 45.500  -21.882 35.706  1.00 75.72  ?  468 VAL A CB  1 
ATOM   2362 C CG1 . VAL A 1 487 ? 46.289  -23.132 35.869  1.00 65.44  ?  468 VAL A CG1 1 
ATOM   2363 C CG2 . VAL A 1 487 ? 46.455  -20.759 35.400  1.00 73.95  ?  468 VAL A CG2 1 
ATOM   2364 N N   . LYS A 1 488 ? 43.962  -24.095 33.443  1.00 92.47  ?  469 LYS A N   1 
ATOM   2365 C CA  . LYS A 1 488 ? 43.094  -25.242 33.261  1.00 86.89  ?  469 LYS A CA  1 
ATOM   2366 C C   . LYS A 1 488 ? 43.544  -26.396 34.147  1.00 91.42  ?  469 LYS A C   1 
ATOM   2367 O O   . LYS A 1 488 ? 44.749  -26.651 34.301  1.00 88.86  ?  469 LYS A O   1 
ATOM   2368 C CB  . LYS A 1 488 ? 42.951  -25.684 31.790  1.00 82.73  ?  469 LYS A CB  1 
ATOM   2369 C CG  . LYS A 1 488 ? 42.278  -24.601 30.883  1.00 101.39 ?  469 LYS A CG  1 
ATOM   2370 C CD  . LYS A 1 488 ? 40.823  -24.254 31.396  1.00 108.92 ?  469 LYS A CD  1 
ATOM   2371 C CE  . LYS A 1 488 ? 40.855  -23.013 32.376  1.00 99.66  ?  469 LYS A CE  1 
ATOM   2372 N NZ  . LYS A 1 488 ? 39.588  -22.480 32.971  1.00 104.75 ?  469 LYS A NZ  1 
ATOM   2373 N N   . PRO A 1 489 ? 42.594  -27.044 34.805  1.00 89.06  ?  470 PRO A N   1 
ATOM   2374 C CA  . PRO A 1 489 ? 42.874  -28.216 35.603  1.00 87.43  ?  470 PRO A CA  1 
ATOM   2375 C C   . PRO A 1 489 ? 43.391  -29.356 34.742  1.00 86.88  ?  470 PRO A C   1 
ATOM   2376 O O   . PRO A 1 489 ? 43.342  -29.289 33.504  1.00 81.36  ?  470 PRO A O   1 
ATOM   2377 C CB  . PRO A 1 489 ? 41.496  -28.554 36.207  1.00 86.00  ?  470 PRO A CB  1 
ATOM   2378 C CG  . PRO A 1 489 ? 40.681  -27.337 36.040  1.00 87.68  ?  470 PRO A CG  1 
ATOM   2379 C CD  . PRO A 1 489 ? 41.161  -26.749 34.761  1.00 88.54  ?  470 PRO A CD  1 
ATOM   2380 N N   . PRO A 1 490 ? 43.895  -30.438 35.366  1.00 90.95  ?  471 PRO A N   1 
ATOM   2381 C CA  . PRO A 1 490 ? 44.115  -30.487 36.814  1.00 84.66  ?  471 PRO A CA  1 
ATOM   2382 C C   . PRO A 1 490 ? 45.332  -29.634 37.180  1.00 82.64  ?  471 PRO A C   1 
ATOM   2383 O O   . PRO A 1 490 ? 46.292  -29.541 36.404  1.00 84.12  ?  471 PRO A O   1 
ATOM   2384 C CB  . PRO A 1 490 ? 44.316  -31.985 37.086  1.00 79.96  ?  471 PRO A CB  1 
ATOM   2385 C CG  . PRO A 1 490 ? 43.638  -32.660 35.922  1.00 80.46  ?  471 PRO A CG  1 
ATOM   2386 C CD  . PRO A 1 490 ? 44.034  -31.774 34.773  1.00 85.53  ?  471 PRO A CD  1 
ATOM   2387 N N   . ARG A 1 491 ? 45.243  -28.981 38.331  1.00 79.20  ?  472 ARG A N   1 
ATOM   2388 C CA  . ARG A 1 491 ? 46.165  -27.944 38.756  1.00 76.18  ?  472 ARG A CA  1 
ATOM   2389 C C   . ARG A 1 491 ? 47.042  -28.503 39.867  1.00 69.55  ?  472 ARG A C   1 
ATOM   2390 O O   . ARG A 1 491 ? 46.620  -29.402 40.589  1.00 78.18  ?  472 ARG A O   1 
ATOM   2391 C CB  . ARG A 1 491 ? 45.372  -26.746 39.279  1.00 77.82  ?  472 ARG A CB  1 
ATOM   2392 C CG  . ARG A 1 491 ? 44.651  -25.968 38.236  1.00 78.31  ?  472 ARG A CG  1 
ATOM   2393 C CD  . ARG A 1 491 ? 44.117  -24.684 38.823  1.00 80.32  ?  472 ARG A CD  1 
ATOM   2394 N NE  . ARG A 1 491 ? 42.784  -24.805 39.410  1.00 84.21  ?  472 ARG A NE  1 
ATOM   2395 C CZ  . ARG A 1 491 ? 41.672  -24.336 38.845  1.00 83.61  ?  472 ARG A CZ  1 
ATOM   2396 N NH1 . ARG A 1 491 ? 41.728  -23.695 37.691  1.00 74.10  ?  472 ARG A NH1 1 
ATOM   2397 N NH2 . ARG A 1 491 ? 40.500  -24.475 39.455  1.00 88.49  ?  472 ARG A NH2 1 
ATOM   2398 N N   . ASP A 1 492 ? 48.252  -27.971 40.038  1.00 69.43  ?  473 ASP A N   1 
ATOM   2399 C CA  . ASP A 1 492 ? 48.921  -28.417 41.248  1.00 69.01  ?  473 ASP A CA  1 
ATOM   2400 C C   . ASP A 1 492 ? 48.360  -27.638 42.439  1.00 76.57  ?  473 ASP A C   1 
ATOM   2401 O O   . ASP A 1 492 ? 47.566  -26.711 42.290  1.00 74.47  ?  473 ASP A O   1 
ATOM   2402 C CB  . ASP A 1 492 ? 50.453  -28.298 41.158  1.00 72.38  ?  473 ASP A CB  1 
ATOM   2403 C CG  . ASP A 1 492 ? 51.005  -26.880 41.322  1.00 80.59  ?  473 ASP A CG  1 
ATOM   2404 O OD1 . ASP A 1 492 ? 50.251  -25.898 41.526  1.00 79.99  ?  473 ASP A OD1 1 
ATOM   2405 O OD2 . ASP A 1 492 ? 52.252  -26.766 41.271  1.00 82.33  ?  473 ASP A OD2 1 
ATOM   2406 N N   . ILE A 1 493 ? 48.772  -28.012 43.644  1.00 80.88  ?  474 ILE A N   1 
ATOM   2407 C CA  . ILE A 1 493 ? 47.971  -27.558 44.768  1.00 78.51  ?  474 ILE A CA  1 
ATOM   2408 C C   . ILE A 1 493 ? 48.200  -26.087 45.115  1.00 76.72  ?  474 ILE A C   1 
ATOM   2409 O O   . ILE A 1 493 ? 47.294  -25.446 45.650  1.00 80.61  ?  474 ILE A O   1 
ATOM   2410 C CB  . ILE A 1 493 ? 48.186  -28.475 45.970  1.00 76.72  ?  474 ILE A CB  1 
ATOM   2411 C CG1 . ILE A 1 493 ? 46.935  -28.413 46.843  1.00 78.24  ?  474 ILE A CG1 1 
ATOM   2412 C CG2 . ILE A 1 493 ? 49.492  -28.114 46.686  1.00 76.50  ?  474 ILE A CG2 1 
ATOM   2413 C CD1 . ILE A 1 493 ? 45.707  -28.987 46.159  1.00 86.50  ?  474 ILE A CD1 1 
ATOM   2414 N N   . THR A 1 494 ? 49.363  -25.501 44.806  1.00 75.82  ?  475 THR A N   1 
ATOM   2415 C CA  . THR A 1 494 ? 49.497  -24.054 45.009  1.00 76.27  ?  475 THR A CA  1 
ATOM   2416 C C   . THR A 1 494 ? 48.530  -23.275 44.112  1.00 78.71  ?  475 THR A C   1 
ATOM   2417 O O   . THR A 1 494 ? 47.915  -22.299 44.550  1.00 84.19  ?  475 THR A O   1 
ATOM   2418 C CB  . THR A 1 494 ? 50.929  -23.570 44.750  1.00 75.09  ?  475 THR A CB  1 
ATOM   2419 O OG1 . THR A 1 494 ? 51.309  -23.896 43.410  1.00 89.03  ?  475 THR A OG1 1 
ATOM   2420 C CG2 . THR A 1 494 ? 51.931  -24.185 45.735  1.00 71.81  ?  475 THR A CG2 1 
ATOM   2421 N N   . ALA A 1 495 ? 48.372  -23.696 42.857  1.00 80.58  ?  476 ALA A N   1 
ATOM   2422 C CA  . ALA A 1 495 ? 47.446  -23.021 41.951  1.00 78.19  ?  476 ALA A CA  1 
ATOM   2423 C C   . ALA A 1 495 ? 45.980  -23.239 42.327  1.00 81.08  ?  476 ALA A C   1 
ATOM   2424 O O   . ALA A 1 495 ? 45.133  -22.393 42.018  1.00 82.60  ?  476 ALA A O   1 
ATOM   2425 C CB  . ALA A 1 495 ? 47.690  -23.494 40.521  1.00 75.37  ?  476 ALA A CB  1 
ATOM   2426 N N   . GLU A 1 496 ? 45.645  -24.376 42.941  1.00 83.01  ?  477 GLU A N   1 
ATOM   2427 C CA  . GLU A 1 496 ? 44.286  -24.569 43.440  1.00 82.47  ?  477 GLU A CA  1 
ATOM   2428 C C   . GLU A 1 496 ? 44.048  -23.706 44.675  1.00 84.28  ?  477 GLU A C   1 
ATOM   2429 O O   . GLU A 1 496 ? 42.970  -23.123 44.842  1.00 85.55  ?  477 GLU A O   1 
ATOM   2430 C CB  . GLU A 1 496 ? 44.051  -26.057 43.736  1.00 82.17  ?  477 GLU A CB  1 
ATOM   2431 C CG  . GLU A 1 496 ? 42.604  -26.480 43.998  1.00 89.89  ?  477 GLU A CG  1 
ATOM   2432 C CD  . GLU A 1 496 ? 41.752  -26.635 42.738  1.00 95.70  ?  477 GLU A CD  1 
ATOM   2433 O OE1 . GLU A 1 496 ? 42.265  -26.475 41.610  1.00 91.82  ?  477 GLU A OE1 1 
ATOM   2434 O OE2 . GLU A 1 496 ? 40.548  -26.944 42.881  1.00 106.78 ?  477 GLU A OE2 1 
ATOM   2435 N N   . PHE A 1 497 ? 45.057  -23.597 45.544  1.00 82.39  ?  478 PHE A N   1 
ATOM   2436 C CA  . PHE A 1 497 ? 44.941  -22.714 46.697  1.00 84.85  ?  478 PHE A CA  1 
ATOM   2437 C C   . PHE A 1 497 ? 44.766  -21.278 46.256  1.00 84.84  ?  478 PHE A C   1 
ATOM   2438 O O   . PHE A 1 497 ? 44.083  -20.506 46.926  1.00 89.98  ?  478 PHE A O   1 
ATOM   2439 C CB  . PHE A 1 497 ? 46.173  -22.854 47.596  1.00 84.38  ?  478 PHE A CB  1 
ATOM   2440 C CG  . PHE A 1 497 ? 46.288  -21.791 48.679  1.00 89.65  ?  478 PHE A CG  1 
ATOM   2441 C CD1 . PHE A 1 497 ? 45.588  -21.908 49.872  1.00 88.91  ?  478 PHE A CD1 1 
ATOM   2442 C CD2 . PHE A 1 497 ? 47.126  -20.698 48.517  1.00 84.43  ?  478 PHE A CD2 1 
ATOM   2443 C CE1 . PHE A 1 497 ? 45.711  -20.951 50.866  1.00 88.45  ?  478 PHE A CE1 1 
ATOM   2444 C CE2 . PHE A 1 497 ? 47.253  -19.749 49.515  1.00 87.60  ?  478 PHE A CE2 1 
ATOM   2445 C CZ  . PHE A 1 497 ? 46.546  -19.874 50.684  1.00 86.47  ?  478 PHE A CZ  1 
ATOM   2446 N N   . LEU A 1 498 ? 45.359  -20.912 45.124  1.00 81.91  ?  479 LEU A N   1 
ATOM   2447 C CA  . LEU A 1 498 ? 45.232  -19.550 44.630  1.00 81.60  ?  479 LEU A CA  1 
ATOM   2448 C C   . LEU A 1 498 ? 43.796  -19.226 44.235  1.00 85.43  ?  479 LEU A C   1 
ATOM   2449 O O   . LEU A 1 498 ? 43.314  -18.119 44.492  1.00 86.33  ?  479 LEU A O   1 
ATOM   2450 C CB  . LEU A 1 498 ? 46.163  -19.345 43.449  1.00 80.67  ?  479 LEU A CB  1 
ATOM   2451 C CG  . LEU A 1 498 ? 46.157  -17.900 42.979  1.00 78.99  ?  479 LEU A CG  1 
ATOM   2452 C CD1 . LEU A 1 498 ? 46.916  -17.080 43.971  1.00 83.47  ?  479 LEU A CD1 1 
ATOM   2453 C CD2 . LEU A 1 498 ? 46.746  -17.777 41.613  1.00 72.93  ?  479 LEU A CD2 1 
ATOM   2454 N N   . VAL A 1 499 ? 43.102  -20.162 43.588  1.00 83.46  ?  480 VAL A N   1 
ATOM   2455 C CA  . VAL A 1 499 ? 41.687  -19.946 43.297  1.00 84.12  ?  480 VAL A CA  1 
ATOM   2456 C C   . VAL A 1 499 ? 40.885  -19.852 44.587  1.00 88.56  ?  480 VAL A C   1 
ATOM   2457 O O   . VAL A 1 499 ? 40.238  -18.835 44.860  1.00 89.45  ?  480 VAL A O   1 
ATOM   2458 C CB  . VAL A 1 499 ? 41.143  -21.045 42.374  1.00 76.27  ?  480 VAL A CB  1 
ATOM   2459 C CG1 . VAL A 1 499 ? 39.637  -20.967 42.313  1.00 81.48  ?  480 VAL A CG1 1 
ATOM   2460 C CG2 . VAL A 1 499 ? 41.668  -20.808 41.001  1.00 82.24  ?  480 VAL A CG2 1 
ATOM   2461 N N   . LYS A 1 500 ? 40.916  -20.918 45.395  1.00 89.66  ?  481 LYS A N   1 
ATOM   2462 C CA  . LYS A 1 500 ? 40.128  -20.961 46.624  1.00 93.28  ?  481 LYS A CA  1 
ATOM   2463 C C   . LYS A 1 500 ? 40.418  -19.758 47.513  1.00 91.21  ?  481 LYS A C   1 
ATOM   2464 O O   . LYS A 1 500 ? 39.519  -19.231 48.174  1.00 90.91  ?  481 LYS A O   1 
ATOM   2465 C CB  . LYS A 1 500 ? 40.417  -22.259 47.386  1.00 95.68  ?  481 LYS A CB  1 
ATOM   2466 C CG  . LYS A 1 500 ? 40.097  -23.552 46.650  1.00 96.70  ?  481 LYS A CG  1 
ATOM   2467 C CD  . LYS A 1 500 ? 38.609  -23.882 46.702  1.00 106.18 ?  481 LYS A CD  1 
ATOM   2468 C CE  . LYS A 1 500 ? 38.397  -25.283 46.202  1.00 106.63 ?  481 LYS A CE  1 
ATOM   2469 N NZ  . LYS A 1 500 ? 39.408  -26.129 46.887  1.00 104.08 ?  481 LYS A NZ  1 
ATOM   2470 N N   . SER A 1 501 ? 41.672  -19.309 47.528  1.00 89.61  ?  482 SER A N   1 
ATOM   2471 C CA  . SER A 1 501 ? 42.073  -18.220 48.404  1.00 86.87  ?  482 SER A CA  1 
ATOM   2472 C C   . SER A 1 501 ? 41.528  -16.881 47.921  1.00 92.43  ?  482 SER A C   1 
ATOM   2473 O O   . SER A 1 501 ? 40.917  -16.140 48.696  1.00 96.35  ?  482 SER A O   1 
ATOM   2474 C CB  . SER A 1 501 ? 43.590  -18.183 48.503  1.00 86.40  ?  482 SER A CB  1 
ATOM   2475 O OG  . SER A 1 501 ? 44.004  -16.976 49.080  1.00 102.71 ?  482 SER A OG  1 
ATOM   2476 N N   . LYS A 1 502 ? 41.752  -16.541 46.649  1.00 89.54  ?  483 LYS A N   1 
ATOM   2477 C CA  . LYS A 1 502 ? 41.153  -15.329 46.102  1.00 85.53  ?  483 LYS A CA  1 
ATOM   2478 C C   . LYS A 1 502 ? 39.634  -15.330 46.256  1.00 87.49  ?  483 LYS A C   1 
ATOM   2479 O O   . LYS A 1 502 ? 39.038  -14.267 46.437  1.00 95.73  ?  483 LYS A O   1 
ATOM   2480 C CB  . LYS A 1 502 ? 41.520  -15.160 44.624  1.00 85.29  ?  483 LYS A CB  1 
ATOM   2481 C CG  . LYS A 1 502 ? 43.001  -14.922 44.309  1.00 83.74  ?  483 LYS A CG  1 
ATOM   2482 C CD  . LYS A 1 502 ? 43.550  -13.650 44.912  1.00 88.23  ?  483 LYS A CD  1 
ATOM   2483 C CE  . LYS A 1 502 ? 45.026  -13.458 44.573  1.00 85.39  ?  483 LYS A CE  1 
ATOM   2484 N NZ  . LYS A 1 502 ? 45.696  -12.337 45.318  1.00 79.97  ?  483 LYS A NZ  1 
ATOM   2485 N N   . HIS A 1 503 ? 38.990  -16.500 46.182  1.00 88.96  ?  484 HIS A N   1 
ATOM   2486 C CA  . HIS A 1 503 ? 37.533  -16.582 46.330  1.00 92.58  ?  484 HIS A CA  1 
ATOM   2487 C C   . HIS A 1 503 ? 37.089  -16.233 47.738  1.00 94.62  ?  484 HIS A C   1 
ATOM   2488 O O   . HIS A 1 503 ? 36.078  -15.549 47.925  1.00 96.87  ?  484 HIS A O   1 
ATOM   2489 C CB  . HIS A 1 503 ? 37.035  -17.988 46.004  1.00 94.33  ?  484 HIS A CB  1 
ATOM   2490 C CG  . HIS A 1 503 ? 35.542  -18.110 45.949  1.00 94.01  ?  484 HIS A CG  1 
ATOM   2491 N ND1 . HIS A 1 503 ? 34.820  -17.876 44.797  1.00 98.70  ?  484 HIS A ND1 1 
ATOM   2492 C CD2 . HIS A 1 503 ? 34.637  -18.440 46.900  1.00 98.19  ?  484 HIS A CD2 1 
ATOM   2493 C CE1 . HIS A 1 503 ? 33.535  -18.065 45.037  1.00 103.79 ?  484 HIS A CE1 1 
ATOM   2494 N NE2 . HIS A 1 503 ? 33.397  -18.409 46.305  1.00 109.03 ?  484 HIS A NE2 1 
ATOM   2495 N N   . ARG A 1 504 ? 37.775  -16.775 48.738  1.00 91.95  ?  485 ARG A N   1 
ATOM   2496 C CA  . ARG A 1 504 ? 37.533  -16.353 50.106  1.00 95.83  ?  485 ARG A CA  1 
ATOM   2497 C C   . ARG A 1 504 ? 37.724  -14.843 50.226  1.00 98.84  ?  485 ARG A C   1 
ATOM   2498 O O   . ARG A 1 504 ? 36.810  -14.115 50.627  1.00 96.45  ?  485 ARG A O   1 
ATOM   2499 C CB  . ARG A 1 504 ? 38.460  -17.131 51.046  1.00 96.17  ?  485 ARG A CB  1 
ATOM   2500 C CG  . ARG A 1 504 ? 38.227  -16.909 52.526  1.00 103.27 ?  485 ARG A CG  1 
ATOM   2501 C CD  . ARG A 1 504 ? 38.893  -15.630 52.970  1.00 102.93 ?  485 ARG A CD  1 
ATOM   2502 N NE  . ARG A 1 504 ? 38.533  -15.239 54.324  1.00 108.73 ?  485 ARG A NE  1 
ATOM   2503 C CZ  . ARG A 1 504 ? 39.114  -14.228 54.960  1.00 110.05 ?  485 ARG A CZ  1 
ATOM   2504 N NH1 . ARG A 1 504 ? 40.074  -13.526 54.355  1.00 98.66  ?  485 ARG A NH1 1 
ATOM   2505 N NH2 . ARG A 1 504 ? 38.744  -13.922 56.199  1.00 115.88 ?  485 ARG A NH2 1 
ATOM   2506 N N   . ASP A 1 505 ? 38.909  -14.358 49.840  1.00 97.45  ?  486 ASP A N   1 
ATOM   2507 C CA  . ASP A 1 505 ? 39.249  -12.947 49.987  1.00 93.06  ?  486 ASP A CA  1 
ATOM   2508 C C   . ASP A 1 505 ? 38.256  -12.040 49.280  1.00 94.72  ?  486 ASP A C   1 
ATOM   2509 O O   . ASP A 1 505 ? 38.022  -10.912 49.723  1.00 98.30  ?  486 ASP A O   1 
ATOM   2510 C CB  . ASP A 1 505 ? 40.657  -12.688 49.449  1.00 91.87  ?  486 ASP A CB  1 
ATOM   2511 C CG  . ASP A 1 505 ? 41.734  -13.198 50.376  1.00 95.52  ?  486 ASP A CG  1 
ATOM   2512 O OD1 . ASP A 1 505 ? 41.373  -13.760 51.438  1.00 100.91 ?  486 ASP A OD1 1 
ATOM   2513 O OD2 . ASP A 1 505 ? 42.934  -13.036 50.047  1.00 94.70  ?  486 ASP A OD2 1 
ATOM   2514 N N   . LEU A 1 506 ? 37.669  -12.497 48.183  1.00 95.19  ?  487 LEU A N   1 
ATOM   2515 C CA  . LEU A 1 506 ? 36.758  -11.625 47.458  1.00 95.48  ?  487 LEU A CA  1 
ATOM   2516 C C   . LEU A 1 506 ? 35.372  -11.610 48.085  1.00 98.47  ?  487 LEU A C   1 
ATOM   2517 O O   . LEU A 1 506 ? 34.750  -10.547 48.166  1.00 102.85 ?  487 LEU A O   1 
ATOM   2518 C CB  . LEU A 1 506 ? 36.691  -12.029 45.988  1.00 92.00  ?  487 LEU A CB  1 
ATOM   2519 C CG  . LEU A 1 506 ? 36.082  -10.957 45.098  1.00 93.32  ?  487 LEU A CG  1 
ATOM   2520 C CD1 . LEU A 1 506 ? 36.801  -10.987 43.808  1.00 97.18  ?  487 LEU A CD1 1 
ATOM   2521 C CD2 . LEU A 1 506 ? 34.605  -11.238 44.862  1.00 94.18  ?  487 LEU A CD2 1 
ATOM   2522 N N   . THR A 1 507 ? 34.863  -12.761 48.534  1.00 98.27  ?  488 THR A N   1 
ATOM   2523 C CA  . THR A 1 507 ? 33.589  -12.737 49.243  1.00 99.38  ?  488 THR A CA  1 
ATOM   2524 C C   . THR A 1 507 ? 33.711  -11.983 50.564  1.00 96.95  ?  488 THR A C   1 
ATOM   2525 O O   . THR A 1 507 ? 32.720  -11.431 51.049  1.00 100.18 ?  488 THR A O   1 
ATOM   2526 C CB  . THR A 1 507 ? 33.057  -14.152 49.488  1.00 93.43  ?  488 THR A CB  1 
ATOM   2527 O OG1 . THR A 1 507 ? 34.067  -14.935 50.127  1.00 97.05  ?  488 THR A OG1 1 
ATOM   2528 C CG2 . THR A 1 507 ? 32.626  -14.817 48.182  1.00 91.40  ?  488 THR A CG2 1 
ATOM   2529 N N   . ALA A 1 508 ? 34.913  -11.926 51.145  1.00 95.97  ?  489 ALA A N   1 
ATOM   2530 C CA  . ALA A 1 508 ? 35.112  -11.180 52.388  1.00 94.25  ?  489 ALA A CA  1 
ATOM   2531 C C   . ALA A 1 508 ? 35.025  -9.669  52.154  1.00 103.02 ?  489 ALA A C   1 
ATOM   2532 O O   . ALA A 1 508 ? 34.281  -8.966  52.848  1.00 107.54 ?  489 ALA A O   1 
ATOM   2533 C CB  . ALA A 1 508 ? 36.451  -11.558 53.025  1.00 91.33  ?  489 ALA A CB  1 
ATOM   2534 N N   . LEU A 1 509 ? 35.780  -9.142  51.190  1.00 97.99  ?  490 LEU A N   1 
ATOM   2535 C CA  . LEU A 1 509 ? 35.582  -7.744  50.833  1.00 94.06  ?  490 LEU A CA  1 
ATOM   2536 C C   . LEU A 1 509 ? 34.181  -7.503  50.301  1.00 99.43  ?  490 LEU A C   1 
ATOM   2537 O O   . LEU A 1 509 ? 33.636  -6.412  50.468  1.00 106.75 ?  490 LEU A O   1 
ATOM   2538 C CB  . LEU A 1 509 ? 36.602  -7.286  49.798  1.00 95.20  ?  490 LEU A CB  1 
ATOM   2539 C CG  . LEU A 1 509 ? 38.077  -7.454  50.124  1.00 93.68  ?  490 LEU A CG  1 
ATOM   2540 C CD1 . LEU A 1 509 ? 38.882  -6.474  49.281  1.00 96.06  ?  490 LEU A CD1 1 
ATOM   2541 C CD2 . LEU A 1 509 ? 38.329  -7.265  51.601  1.00 94.38  ?  490 LEU A CD2 1 
ATOM   2542 N N   . CYS A 1 510 ? 33.583  -8.487  49.639  1.00 103.11 ?  491 CYS A N   1 
ATOM   2543 C CA  . CYS A 1 510 ? 32.193  -8.313  49.241  1.00 106.08 ?  491 CYS A CA  1 
ATOM   2544 C C   . CYS A 1 510 ? 31.244  -8.257  50.429  1.00 109.53 ?  491 CYS A C   1 
ATOM   2545 O O   . CYS A 1 510 ? 30.098  -7.826  50.266  1.00 110.01 ?  491 CYS A O   1 
ATOM   2546 C CB  . CYS A 1 510 ? 31.764  -9.428  48.290  1.00 101.04 ?  491 CYS A CB  1 
ATOM   2547 S SG  . CYS A 1 510 ? 32.170  -9.044  46.609  1.00 108.56 ?  491 CYS A SG  1 
ATOM   2548 N N   . LYS A 1 511 ? 31.681  -8.677  51.611  1.00 107.73 ?  492 LYS A N   1 
ATOM   2549 C CA  . LYS A 1 511 ? 30.808  -8.540  52.764  1.00 112.60 ?  492 LYS A CA  1 
ATOM   2550 C C   . LYS A 1 511 ? 31.031  -7.211  53.488  1.00 114.39 ?  492 LYS A C   1 
ATOM   2551 O O   . LYS A 1 511 ? 30.059  -6.593  53.933  1.00 116.88 ?  492 LYS A O   1 
ATOM   2552 C CB  . LYS A 1 511 ? 30.979  -9.741  53.705  1.00 106.12 ?  492 LYS A CB  1 
ATOM   2553 C CG  . LYS A 1 511 ? 30.211  -9.660  55.032  1.00 118.40 ?  492 LYS A CG  1 
ATOM   2554 C CD  . LYS A 1 511 ? 28.695  -9.313  54.902  1.00 128.02 ?  492 LYS A CD  1 
ATOM   2555 C CE  . LYS A 1 511 ? 27.941  -10.043 53.765  1.00 128.60 ?  492 LYS A CE  1 
ATOM   2556 N NZ  . LYS A 1 511 ? 26.472  -10.188 54.038  1.00 129.25 ?  492 LYS A NZ  1 
ATOM   2557 N N   . GLU A 1 512 ? 32.280  -6.735  53.590  1.00 110.32 ?  493 GLU A N   1 
ATOM   2558 C CA  . GLU A 1 512 ? 32.508  -5.404  54.152  1.00 108.34 ?  493 GLU A CA  1 
ATOM   2559 C C   . GLU A 1 512 ? 31.738  -4.346  53.381  1.00 108.19 ?  493 GLU A C   1 
ATOM   2560 O O   . GLU A 1 512 ? 31.180  -3.420  53.976  1.00 112.04 ?  493 GLU A O   1 
ATOM   2561 C CB  . GLU A 1 512 ? 33.994  -5.050  54.152  1.00 104.41 ?  493 GLU A CB  1 
ATOM   2562 C CG  . GLU A 1 512 ? 34.873  -6.027  54.896  1.00 110.76 ?  493 GLU A CG  1 
ATOM   2563 C CD  . GLU A 1 512 ? 36.340  -5.647  54.804  1.00 115.10 ?  493 GLU A CD  1 
ATOM   2564 O OE1 . GLU A 1 512 ? 36.623  -4.492  54.390  1.00 108.53 ?  493 GLU A OE1 1 
ATOM   2565 O OE2 . GLU A 1 512 ? 37.198  -6.503  55.140  1.00 117.43 ?  493 GLU A OE2 1 
ATOM   2566 N N   . TYR A 1 513 ? 31.696  -4.468  52.052  1.00 106.33 ?  494 TYR A N   1 
ATOM   2567 C CA  . TYR A 1 513 ? 30.979  -3.509  51.219  1.00 101.76 ?  494 TYR A CA  1 
ATOM   2568 C C   . TYR A 1 513 ? 29.481  -3.570  51.426  1.00 104.78 ?  494 TYR A C   1 
ATOM   2569 O O   . TYR A 1 513 ? 28.793  -2.585  51.156  1.00 108.10 ?  494 TYR A O   1 
ATOM   2570 C CB  . TYR A 1 513 ? 31.287  -3.750  49.746  1.00 95.93  ?  494 TYR A CB  1 
ATOM   2571 C CG  . TYR A 1 513 ? 30.751  -2.700  48.818  1.00 88.42  ?  494 TYR A CG  1 
ATOM   2572 C CD1 . TYR A 1 513 ? 31.555  -1.653  48.393  1.00 90.79  ?  494 TYR A CD1 1 
ATOM   2573 C CD2 . TYR A 1 513 ? 29.449  -2.765  48.345  1.00 86.61  ?  494 TYR A CD2 1 
ATOM   2574 C CE1 . TYR A 1 513 ? 31.070  -0.690  47.536  1.00 90.00  ?  494 TYR A CE1 1 
ATOM   2575 C CE2 . TYR A 1 513 ? 28.959  -1.812  47.489  1.00 90.43  ?  494 TYR A CE2 1 
ATOM   2576 C CZ  . TYR A 1 513 ? 29.769  -0.776  47.088  1.00 89.84  ?  494 TYR A CZ  1 
ATOM   2577 O OH  . TYR A 1 513 ? 29.269  0.173   46.233  1.00 95.42  ?  494 TYR A OH  1 
ATOM   2578 N N   . ASP A 1 514 ? 28.952  -4.701  51.874  1.00 108.41 ?  495 ASP A N   1 
ATOM   2579 C CA  . ASP A 1 514 ? 27.515  -4.766  52.100  1.00 114.10 ?  495 ASP A CA  1 
ATOM   2580 C C   . ASP A 1 514 ? 27.140  -4.128  53.436  1.00 111.96 ?  495 ASP A C   1 
ATOM   2581 O O   . ASP A 1 514 ? 26.151  -3.389  53.516  1.00 110.88 ?  495 ASP A O   1 
ATOM   2582 C CB  . ASP A 1 514 ? 27.043  -6.221  52.008  1.00 119.48 ?  495 ASP A CB  1 
ATOM   2583 C CG  . ASP A 1 514 ? 27.185  -6.790  50.600  1.00 118.86 ?  495 ASP A CG  1 
ATOM   2584 O OD1 . ASP A 1 514 ? 27.289  -5.974  49.652  1.00 108.27 ?  495 ASP A OD1 1 
ATOM   2585 O OD2 . ASP A 1 514 ? 27.184  -8.041  50.444  1.00 121.06 ?  495 ASP A OD2 1 
ATOM   2586 N N   . GLU A 1 515 ? 27.933  -4.389  54.482  1.00 109.18 ?  496 GLU A N   1 
ATOM   2587 C CA  . GLU A 1 515 ? 27.737  -3.736  55.770  1.00 111.43 ?  496 GLU A CA  1 
ATOM   2588 C C   . GLU A 1 515 ? 27.967  -2.232  55.670  1.00 113.10 ?  496 GLU A C   1 
ATOM   2589 O O   . GLU A 1 515 ? 27.360  -1.457  56.415  1.00 114.73 ?  496 GLU A O   1 
ATOM   2590 C CB  . GLU A 1 515 ? 28.670  -4.359  56.809  1.00 112.38 ?  496 GLU A CB  1 
ATOM   2591 C CG  . GLU A 1 515 ? 28.393  -5.845  57.055  1.00 124.41 ?  496 GLU A CG  1 
ATOM   2592 C CD  . GLU A 1 515 ? 29.464  -6.521  57.904  1.00 130.15 ?  496 GLU A CD  1 
ATOM   2593 O OE1 . GLU A 1 515 ? 30.552  -5.917  58.069  1.00 129.27 ?  496 GLU A OE1 1 
ATOM   2594 O OE2 . GLU A 1 515 ? 29.221  -7.655  58.391  1.00 125.82 ?  496 GLU A OE2 1 
ATOM   2595 N N   . LEU A 1 516 ? 28.820  -1.803  54.750  1.00 110.68 ?  497 LEU A N   1 
ATOM   2596 C CA  . LEU A 1 516 ? 29.032  -0.385  54.527  1.00 106.04 ?  497 LEU A CA  1 
ATOM   2597 C C   . LEU A 1 516 ? 27.951  0.261   53.666  1.00 110.55 ?  497 LEU A C   1 
ATOM   2598 O O   . LEU A 1 516 ? 28.003  1.477   53.466  1.00 115.20 ?  497 LEU A O   1 
ATOM   2599 C CB  . LEU A 1 516 ? 30.396  -0.152  53.872  1.00 106.29 ?  497 LEU A CB  1 
ATOM   2600 C CG  . LEU A 1 516 ? 31.556  0.226   54.790  1.00 103.43 ?  497 LEU A CG  1 
ATOM   2601 C CD1 . LEU A 1 516 ? 31.764  -0.815  55.896  1.00 96.74  ?  497 LEU A CD1 1 
ATOM   2602 C CD2 . LEU A 1 516 ? 32.801  0.391   53.949  1.00 102.21 ?  497 LEU A CD2 1 
ATOM   2603 N N   . ALA A 1 517 ? 27.002  -0.493  53.111  1.00 108.66 ?  498 ALA A N   1 
ATOM   2604 C CA  . ALA A 1 517 ? 25.898  0.127   52.389  1.00 109.56 ?  498 ALA A CA  1 
ATOM   2605 C C   . ALA A 1 517 ? 24.596  -0.088  53.123  1.00 112.95 ?  498 ALA A C   1 
ATOM   2606 O O   . ALA A 1 517 ? 23.530  0.268   52.610  1.00 112.67 ?  498 ALA A O   1 
ATOM   2607 C CB  . ALA A 1 517 ? 25.779  -0.407  50.962  1.00 104.99 ?  498 ALA A CB  1 
ATOM   2608 N N   . GLU A 1 518 ? 24.737  -0.800  54.227  1.00 113.01 ?  499 GLU A N   1 
ATOM   2609 C CA  . GLU A 1 518 ? 23.635  -0.945  55.184  1.00 119.10 ?  499 GLU A CA  1 
ATOM   2610 C C   . GLU A 1 518 ? 23.783  0.361   55.939  1.00 115.77 ?  499 GLU A C   1 
ATOM   2611 O O   . GLU A 1 518 ? 22.919  1.216   55.837  1.00 117.78 ?  499 GLU A O   1 
ATOM   2612 C CB  . GLU A 1 518 ? 23.926  -2.104  56.130  1.00 122.27 ?  499 GLU A CB  1 
ATOM   2613 C CG  . GLU A 1 518 ? 22.796  -3.106  56.231  1.00 127.46 ?  499 GLU A CG  1 
ATOM   2614 C CD  . GLU A 1 518 ? 21.682  -2.883  55.227  1.00 135.14 ?  499 GLU A CD  1 
ATOM   2615 O OE1 . GLU A 1 518 ? 20.510  -2.841  55.642  1.00 135.92 ?  499 GLU A OE1 1 
ATOM   2616 O OE2 . GLU A 1 518 ? 21.990  -2.752  54.036  1.00 136.73 ?  499 GLU A OE2 1 
ATOM   2617 N N   . THR A 1 519 ? 24.981  0.570   56.468  1.00 112.53 ?  500 THR A N   1 
ATOM   2618 C CA  . THR A 1 519 ? 25.296  1.812   57.195  1.00 111.75 ?  500 THR A CA  1 
ATOM   2619 C C   . THR A 1 519 ? 25.136  3.015   56.275  1.00 110.25 ?  500 THR A C   1 
ATOM   2620 O O   . THR A 1 519 ? 24.737  4.038   56.761  1.00 113.70 ?  500 THR A O   1 
ATOM   2621 C CB  . THR A 1 519 ? 26.744  1.823   57.660  1.00 109.46 ?  500 THR A CB  1 
ATOM   2622 O OG1 . THR A 1 519 ? 26.768  1.153   58.913  1.00 106.32 ?  500 THR A OG1 1 
ATOM   2623 C CG2 . THR A 1 519 ? 27.254  3.231   57.832  1.00 106.90 ?  500 THR A CG2 1 
ATOM   2624 N N   . GLN A 1 520 ? 25.491  2.921   55.003  1.00 108.29 ?  501 GLN A N   1 
ATOM   2625 C CA  . GLN A 1 520 ? 25.284  4.101   54.142  1.00 107.78 ?  501 GLN A CA  1 
ATOM   2626 C C   . GLN A 1 520 ? 23.799  4.429   54.122  1.00 110.73 ?  501 GLN A C   1 
ATOM   2627 O O   . GLN A 1 520 ? 23.460  5.570   54.308  1.00 114.74 ?  501 GLN A O   1 
ATOM   2628 C CB  . GLN A 1 520 ? 25.698  3.829   52.704  1.00 107.21 ?  501 GLN A CB  1 
ATOM   2629 C CG  . GLN A 1 520 ? 25.521  5.059   51.839  1.00 105.68 ?  501 GLN A CG  1 
ATOM   2630 C CD  . GLN A 1 520 ? 25.381  4.764   50.373  1.00 106.74 ?  501 GLN A CD  1 
ATOM   2631 O OE1 . GLN A 1 520 ? 26.241  4.157   49.768  1.00 113.99 ?  501 GLN A OE1 1 
ATOM   2632 N NE2 . GLN A 1 520 ? 24.297  5.221   49.783  1.00 107.05 ?  501 GLN A NE2 1 
ATOM   2633 N N   . GLY A 1 521 ? 22.955  3.431   53.922  1.00 113.42 ?  502 GLY A N   1 
ATOM   2634 C CA  . GLY A 1 521 ? 21.504  3.662   53.860  1.00 115.26 ?  502 GLY A CA  1 
ATOM   2635 C C   . GLY A 1 521 ? 20.982  4.420   55.058  1.00 112.85 ?  502 GLY A C   1 
ATOM   2636 O O   . GLY A 1 521 ? 20.192  5.318   54.858  1.00 113.87 ?  502 GLY A O   1 
ATOM   2637 N N   . LYS A 1 522 ? 21.393  4.044   56.261  1.00 106.29 ?  503 LYS A N   1 
ATOM   2638 C CA  . LYS A 1 522 ? 20.921  4.759   57.462  1.00 110.56 ?  503 LYS A CA  1 
ATOM   2639 C C   . LYS A 1 522 ? 21.294  6.230   57.325  1.00 120.43 ?  503 LYS A C   1 
ATOM   2640 O O   . LYS A 1 522 ? 20.411  7.075   57.313  1.00 122.14 ?  503 LYS A O   1 
ATOM   2641 C CB  . LYS A 1 522 ? 21.593  4.164   58.695  1.00 109.89 ?  503 LYS A CB  1 
ATOM   2642 C CG  . LYS A 1 522 ? 21.220  2.718   58.967  1.00 105.87 ?  503 LYS A CG  1 
ATOM   2643 C CD  . LYS A 1 522 ? 21.581  2.251   60.350  1.00 111.26 ?  503 LYS A CD  1 
ATOM   2644 C CE  . LYS A 1 522 ? 22.987  2.624   60.765  1.00 110.69 ?  503 LYS A CE  1 
ATOM   2645 N NZ  . LYS A 1 522 ? 23.498  1.732   61.832  1.00 109.29 ?  503 LYS A NZ  1 
ATOM   2646 N N   . LEU A 1 523 ? 22.560  6.523   57.058  1.00 119.89 ?  504 LEU A N   1 
ATOM   2647 C CA  . LEU A 1 523 ? 23.026  7.929   56.953  1.00 110.32 ?  504 LEU A CA  1 
ATOM   2648 C C   . LEU A 1 523 ? 22.274  8.730   55.896  1.00 114.23 ?  504 LEU A C   1 
ATOM   2649 O O   . LEU A 1 523 ? 22.065  9.898   56.124  1.00 117.57 ?  504 LEU A O   1 
ATOM   2650 C CB  . LEU A 1 523 ? 24.527  7.936   56.702  1.00 106.47 ?  504 LEU A CB  1 
ATOM   2651 C CG  . LEU A 1 523 ? 25.316  7.375   57.871  1.00 113.89 ?  504 LEU A CG  1 
ATOM   2652 C CD1 . LEU A 1 523 ? 26.525  8.231   58.174  1.00 113.55 ?  504 LEU A CD1 1 
ATOM   2653 C CD2 . LEU A 1 523 ? 24.422  7.275   59.089  1.00 115.41 ?  504 LEU A CD2 1 
ATOM   2654 N N   . GLU A 1 524 ? 21.814  8.129   54.803  1.00 115.87 ?  505 GLU A N   1 
ATOM   2655 C CA  . GLU A 1 524 ? 21.055  8.900   53.794  1.00 118.48 ?  505 GLU A CA  1 
ATOM   2656 C C   . GLU A 1 524 ? 19.657  9.219   54.324  1.00 118.24 ?  505 GLU A C   1 
ATOM   2657 O O   . GLU A 1 524 ? 19.045  10.137  53.800  1.00 114.75 ?  505 GLU A O   1 
ATOM   2658 C CB  . GLU A 1 524 ? 20.960  8.112   52.492  1.00 117.04 ?  505 GLU A CB  1 
ATOM   2659 C CG  . GLU A 1 524 ? 22.274  8.022   51.751  1.00 120.17 ?  505 GLU A CG  1 
ATOM   2660 C CD  . GLU A 1 524 ? 22.182  8.198   50.248  1.00 127.99 ?  505 GLU A CD  1 
ATOM   2661 O OE1 . GLU A 1 524 ? 21.309  7.564   49.634  1.00 128.79 ?  505 GLU A OE1 1 
ATOM   2662 O OE2 . GLU A 1 524 ? 22.985  8.966   49.699  1.00 125.37 ?  505 GLU A OE2 1 
ATOM   2663 N N   . GLU A 1 525 ? 19.156  8.452   55.287  1.00 118.76 ?  506 GLU A N   1 
ATOM   2664 C CA  . GLU A 1 525 ? 17.819  8.695   55.863  1.00 123.12 ?  506 GLU A CA  1 
ATOM   2665 C C   . GLU A 1 525 ? 17.934  9.783   56.934  1.00 123.54 ?  506 GLU A C   1 
ATOM   2666 O O   . GLU A 1 525 ? 17.214  10.779  56.834  1.00 123.61 ?  506 GLU A O   1 
ATOM   2667 C CB  . GLU A 1 525 ? 17.251  7.346   56.300  1.00 121.68 ?  506 GLU A CB  1 
ATOM   2668 C CG  . GLU A 1 525 ? 16.632  7.326   57.675  1.00 129.63 ?  506 GLU A CG  1 
ATOM   2669 C CD  . GLU A 1 525 ? 17.549  6.765   58.741  1.00 133.62 ?  506 GLU A CD  1 
ATOM   2670 O OE1 . GLU A 1 525 ? 17.537  5.541   58.940  1.00 127.51 ?  506 GLU A OE1 1 
ATOM   2671 O OE2 . GLU A 1 525 ? 18.257  7.554   59.378  1.00 139.11 ?  506 GLU A OE2 1 
ATOM   2672 N N   . LYS A 1 526 ? 18.877  9.642   57.858  1.00 119.03 ?  507 LYS A N   1 
ATOM   2673 C CA  . LYS A 1 526 ? 19.031  10.628  58.948  1.00 117.27 ?  507 LYS A CA  1 
ATOM   2674 C C   . LYS A 1 526 ? 19.223  12.032  58.389  1.00 114.71 ?  507 LYS A C   1 
ATOM   2675 O O   . LYS A 1 526 ? 19.110  12.965  59.130  1.00 120.11 ?  507 LYS A O   1 
ATOM   2676 C CB  . LYS A 1 526 ? 20.203  10.211  59.819  1.00 111.27 ?  507 LYS A CB  1 
ATOM   2677 C CG  . LYS A 1 526 ? 20.778  11.336  60.645  1.00 114.88 ?  507 LYS A CG  1 
ATOM   2678 C CD  . LYS A 1 526 ? 21.324  10.838  61.950  1.00 117.79 ?  507 LYS A CD  1 
ATOM   2679 C CE  . LYS A 1 526 ? 21.111  9.356   62.143  1.00 116.24 ?  507 LYS A CE  1 
ATOM   2680 N NZ  . LYS A 1 526 ? 21.760  8.876   63.382  1.00 115.06 ?  507 LYS A NZ  1 
ATOM   2681 N N   . LEU A 1 527 ? 19.504  12.146  57.110  1.00 115.59 ?  508 LEU A N   1 
ATOM   2682 C CA  . LEU A 1 527 ? 19.689  13.413  56.427  1.00 119.20 ?  508 LEU A CA  1 
ATOM   2683 C C   . LEU A 1 527 ? 18.445  13.906  55.728  1.00 121.44 ?  508 LEU A C   1 
ATOM   2684 O O   . LEU A 1 527 ? 18.385  15.088  55.375  1.00 122.42 ?  508 LEU A O   1 
ATOM   2685 C CB  . LEU A 1 527 ? 20.831  13.297  55.425  1.00 120.62 ?  508 LEU A CB  1 
ATOM   2686 C CG  . LEU A 1 527 ? 22.077  13.181  56.294  1.00 120.37 ?  508 LEU A CG  1 
ATOM   2687 C CD1 . LEU A 1 527 ? 23.349  13.231  55.520  1.00 115.13 ?  508 LEU A CD1 1 
ATOM   2688 C CD2 . LEU A 1 527 ? 22.049  14.340  57.275  1.00 116.17 ?  508 LEU A CD2 1 
ATOM   2689 N N   . GLN A 1 528 ? 17.473  13.036  55.494  1.00 122.46 ?  509 GLN A N   1 
ATOM   2690 C CA  . GLN A 1 528 ? 16.128  13.530  55.288  1.00 125.73 ?  509 GLN A CA  1 
ATOM   2691 C C   . GLN A 1 528 ? 15.363  13.677  56.594  1.00 124.75 ?  509 GLN A C   1 
ATOM   2692 O O   . GLN A 1 528 ? 14.414  14.461  56.643  1.00 122.61 ?  509 GLN A O   1 
ATOM   2693 C CB  . GLN A 1 528 ? 15.371  12.639  54.305  1.00 124.11 ?  509 GLN A CB  1 
ATOM   2694 C CG  . GLN A 1 528 ? 16.054  12.550  52.969  1.00 130.55 ?  509 GLN A CG  1 
ATOM   2695 C CD  . GLN A 1 528 ? 15.056  12.433  51.829  1.00 138.61 ?  509 GLN A CD  1 
ATOM   2696 O OE1 . GLN A 1 528 ? 14.024  11.764  51.951  1.00 133.90 ?  509 GLN A OE1 1 
ATOM   2697 N NE2 . GLN A 1 528 ? 15.338  13.127  50.724  1.00 137.32 ?  509 GLN A NE2 1 
ATOM   2698 N N   . GLU A 1 529 ? 15.763  12.973  57.656  1.00 121.41 ?  510 GLU A N   1 
ATOM   2699 C CA  . GLU A 1 529 ? 15.220  13.283  58.972  1.00 121.82 ?  510 GLU A CA  1 
ATOM   2700 C C   . GLU A 1 529 ? 15.577  14.726  59.297  1.00 125.14 ?  510 GLU A C   1 
ATOM   2701 O O   . GLU A 1 529 ? 14.704  15.602  59.325  1.00 123.96 ?  510 GLU A O   1 
ATOM   2702 C CB  . GLU A 1 529 ? 15.761  12.333  60.051  1.00 119.41 ?  510 GLU A CB  1 
ATOM   2703 C CG  . GLU A 1 529 ? 15.337  12.688  61.476  1.00 126.12 ?  510 GLU A CG  1 
ATOM   2704 C CD  . GLU A 1 529 ? 13.928  12.217  61.801  1.00 134.46 ?  510 GLU A CD  1 
ATOM   2705 O OE1 . GLU A 1 529 ? 13.415  11.347  61.061  1.00 129.66 ?  510 GLU A OE1 1 
ATOM   2706 O OE2 . GLU A 1 529 ? 13.339  12.715  62.791  1.00 134.89 ?  510 GLU A OE2 1 
ATOM   2707 N N   . LEU A 1 530 ? 16.871  14.987  59.486  1.00 121.90 ?  511 LEU A N   1 
ATOM   2708 C CA  . LEU A 1 530 ? 17.287  16.304  59.932  1.00 110.98 ?  511 LEU A CA  1 
ATOM   2709 C C   . LEU A 1 530 ? 16.895  17.383  58.936  1.00 114.82 ?  511 LEU A C   1 
ATOM   2710 O O   . LEU A 1 530 ? 16.347  18.411  59.336  1.00 119.33 ?  511 LEU A O   1 
ATOM   2711 C CB  . LEU A 1 530 ? 18.784  16.328  60.224  1.00 106.13 ?  511 LEU A CB  1 
ATOM   2712 C CG  . LEU A 1 530 ? 19.285  15.299  61.253  1.00 112.17 ?  511 LEU A CG  1 
ATOM   2713 C CD1 . LEU A 1 530 ? 20.597  15.771  61.870  1.00 112.25 ?  511 LEU A CD1 1 
ATOM   2714 C CD2 . LEU A 1 530 ? 18.265  14.927  62.347  1.00 109.95 ?  511 LEU A CD2 1 
ATOM   2715 N N   . GLU A 1 531 ? 17.138  17.200  57.645  1.00 117.91 ?  512 GLU A N   1 
ATOM   2716 C CA  . GLU A 1 531 ? 16.708  18.365  56.878  1.00 123.39 ?  512 GLU A CA  1 
ATOM   2717 C C   . GLU A 1 531 ? 15.193  18.388  56.608  1.00 123.73 ?  512 GLU A C   1 
ATOM   2718 O O   . GLU A 1 531 ? 14.684  19.405  56.127  1.00 126.86 ?  512 GLU A O   1 
ATOM   2719 C CB  . GLU A 1 531 ? 17.614  18.592  55.625  1.00 125.46 ?  512 GLU A CB  1 
ATOM   2720 C CG  . GLU A 1 531 ? 17.175  19.866  54.830  1.00 134.88 ?  512 GLU A CG  1 
ATOM   2721 C CD  . GLU A 1 531 ? 16.494  19.542  53.493  1.00 138.79 ?  512 GLU A CD  1 
ATOM   2722 O OE1 . GLU A 1 531 ? 17.168  18.859  52.663  1.00 138.32 ?  512 GLU A OE1 1 
ATOM   2723 O OE2 . GLU A 1 531 ? 15.220  19.683  53.426  1.00 138.93 ?  512 GLU A OE2 1 
ATOM   2724 N N   . ALA A 1 532 ? 14.405  17.431  57.108  1.00 124.44 ?  513 ALA A N   1 
ATOM   2725 C CA  . ALA A 1 532 ? 12.953  17.654  57.066  1.00 127.11 ?  513 ALA A CA  1 
ATOM   2726 C C   . ALA A 1 532 ? 12.379  18.293  58.333  1.00 127.01 ?  513 ALA A C   1 
ATOM   2727 O O   . ALA A 1 532 ? 11.269  18.837  58.275  1.00 122.70 ?  513 ALA A O   1 
ATOM   2728 C CB  . ALA A 1 532 ? 12.178  16.360  56.779  1.00 122.46 ?  513 ALA A CB  1 
ATOM   2729 N N   . ASN A 1 533 ? 13.108  18.276  59.461  1.00 126.22 ?  514 ASN A N   1 
ATOM   2730 C CA  . ASN A 1 533 ? 12.644  18.927  60.687  1.00 121.59 ?  514 ASN A CA  1 
ATOM   2731 C C   . ASN A 1 533 ? 13.514  20.121  61.082  1.00 118.41 ?  514 ASN A C   1 
ATOM   2732 O O   . ASN A 1 533 ? 14.148  20.087  62.149  1.00 116.90 ?  514 ASN A O   1 
ATOM   2733 C CB  . ASN A 1 533 ? 12.604  17.933  61.856  1.00 119.36 ?  514 ASN A CB  1 
ATOM   2734 C CG  . ASN A 1 533 ? 11.448  16.961  61.758  1.00 123.35 ?  514 ASN A CG  1 
ATOM   2735 O OD1 . ASN A 1 533 ? 10.642  17.036  60.826  1.00 120.88 ?  514 ASN A OD1 1 
ATOM   2736 N ND2 . ASN A 1 533 ? 11.339  16.059  62.740  1.00 121.23 ?  514 ASN A ND2 1 
ATOM   2737 N N   . PRO A 1 534 ? 13.561  21.193  60.290  1.00 114.94 ?  515 PRO A N   1 
ATOM   2738 C CA  . PRO A 1 534 ? 14.407  22.323  60.650  1.00 111.93 ?  515 PRO A CA  1 
ATOM   2739 C C   . PRO A 1 534 ? 13.748  23.146  61.739  1.00 117.30 ?  515 PRO A C   1 
ATOM   2740 O O   . PRO A 1 534 ? 12.516  23.294  61.755  1.00 120.28 ?  515 PRO A O   1 
ATOM   2741 C CB  . PRO A 1 534 ? 14.516  23.112  59.338  1.00 108.70 ?  515 PRO A CB  1 
ATOM   2742 C CG  . PRO A 1 534 ? 13.229  22.882  58.677  1.00 107.91 ?  515 PRO A CG  1 
ATOM   2743 C CD  . PRO A 1 534 ? 12.782  21.482  59.070  1.00 117.09 ?  515 PRO A CD  1 
ATOM   2744 N N   . PRO A 1 535 ? 14.523  23.692  62.671  1.00 114.78 ?  516 PRO A N   1 
ATOM   2745 C CA  . PRO A 1 535 ? 13.923  24.541  63.700  1.00 110.86 ?  516 PRO A CA  1 
ATOM   2746 C C   . PRO A 1 535 ? 13.393  25.834  63.098  1.00 112.72 ?  516 PRO A C   1 
ATOM   2747 O O   . PRO A 1 535 ? 13.418  26.021  61.873  1.00 106.98 ?  516 PRO A O   1 
ATOM   2748 C CB  . PRO A 1 535 ? 15.082  24.784  64.672  1.00 105.22 ?  516 PRO A CB  1 
ATOM   2749 C CG  . PRO A 1 535 ? 16.283  24.707  63.827  1.00 105.82 ?  516 PRO A CG  1 
ATOM   2750 C CD  . PRO A 1 535 ? 15.986  23.633  62.804  1.00 112.75 ?  516 PRO A CD  1 
ATOM   2751 N N   . SER A 1 536 ? 12.927  26.731  63.968  1.00 117.61 ?  517 SER A N   1 
ATOM   2752 C CA  . SER A 1 536 ? 12.158  27.893  63.545  1.00 109.20 ?  517 SER A CA  1 
ATOM   2753 C C   . SER A 1 536 ? 13.018  28.847  62.733  1.00 101.87 ?  517 SER A C   1 
ATOM   2754 O O   . SER A 1 536 ? 14.165  29.124  63.087  1.00 97.84  ?  517 SER A O   1 
ATOM   2755 C CB  . SER A 1 536 ? 11.588  28.607  64.766  1.00 114.67 ?  517 SER A CB  1 
ATOM   2756 O OG  . SER A 1 536 ? 10.785  27.719  65.531  1.00 116.97 ?  517 SER A OG  1 
ATOM   2757 N N   . ASP A 1 537 ? 12.438  29.349  61.640  1.00 103.98 ?  518 ASP A N   1 
ATOM   2758 C CA  . ASP A 1 537 ? 13.161  30.199  60.699  1.00 106.16 ?  518 ASP A CA  1 
ATOM   2759 C C   . ASP A 1 537 ? 13.472  31.578  61.302  1.00 111.42 ?  518 ASP A C   1 
ATOM   2760 O O   . ASP A 1 537 ? 14.596  32.083  61.164  1.00 109.92 ?  518 ASP A O   1 
ATOM   2761 C CB  . ASP A 1 537 ? 12.331  30.297  59.411  1.00 109.21 ?  518 ASP A CB  1 
ATOM   2762 C CG  . ASP A 1 537 ? 12.996  31.124  58.315  1.00 118.96 ?  518 ASP A CG  1 
ATOM   2763 O OD1 . ASP A 1 537 ? 14.156  31.569  58.482  1.00 118.30 ?  518 ASP A OD1 1 
ATOM   2764 O OD2 . ASP A 1 537 ? 12.336  31.328  57.268  1.00 121.32 ?  518 ASP A OD2 1 
ATOM   2765 N N   . VAL A 1 538 ? 12.501  32.199  61.988  1.00 112.81 ?  519 VAL A N   1 
ATOM   2766 C CA  . VAL A 1 538 ? 12.683  33.495  62.646  1.00 105.69 ?  519 VAL A CA  1 
ATOM   2767 C C   . VAL A 1 538 ? 12.077  33.453  64.047  1.00 100.64 ?  519 VAL A C   1 
ATOM   2768 O O   . VAL A 1 538 ? 11.402  32.496  64.438  1.00 101.48 ?  519 VAL A O   1 
ATOM   2769 C CB  . VAL A 1 538 ? 12.054  34.656  61.844  1.00 99.57  ?  519 VAL A CB  1 
ATOM   2770 C CG1 . VAL A 1 538 ? 12.822  34.876  60.550  1.00 111.42 ?  519 VAL A CG1 1 
ATOM   2771 C CG2 . VAL A 1 538 ? 10.583  34.382  61.574  1.00 90.13  ?  519 VAL A CG2 1 
ATOM   2772 N N   . TYR A 1 539 ? 12.333  34.518  64.811  1.00 98.07  ?  520 TYR A N   1 
ATOM   2773 C CA  . TYR A 1 539 ? 11.600  34.718  66.054  1.00 92.20  ?  520 TYR A CA  1 
ATOM   2774 C C   . TYR A 1 539 ? 10.279  35.430  65.805  1.00 91.03  ?  520 TYR A C   1 
ATOM   2775 O O   . TYR A 1 539 ? 9.231   34.987  66.286  1.00 87.41  ?  520 TYR A O   1 
ATOM   2776 C CB  . TYR A 1 539 ? 12.427  35.514  67.055  1.00 91.28  ?  520 TYR A CB  1 
ATOM   2777 C CG  . TYR A 1 539 ? 11.658  35.759  68.320  1.00 94.90  ?  520 TYR A CG  1 
ATOM   2778 C CD1 . TYR A 1 539 ? 10.976  34.721  68.949  1.00 94.19  ?  520 TYR A CD1 1 
ATOM   2779 C CD2 . TYR A 1 539 ? 11.599  37.022  68.890  1.00 93.09  ?  520 TYR A CD2 1 
ATOM   2780 C CE1 . TYR A 1 539 ? 10.261  34.934  70.119  1.00 92.93  ?  520 TYR A CE1 1 
ATOM   2781 C CE2 . TYR A 1 539 ? 10.886  37.247  70.060  1.00 90.62  ?  520 TYR A CE2 1 
ATOM   2782 C CZ  . TYR A 1 539 ? 10.218  36.203  70.670  1.00 94.28  ?  520 TYR A CZ  1 
ATOM   2783 O OH  . TYR A 1 539 ? 9.507   36.428  71.832  1.00 88.39  ?  520 TYR A OH  1 
ATOM   2784 N N   . LEU A 1 540 ? 10.320  36.519  65.039  1.00 88.75  ?  521 LEU A N   1 
ATOM   2785 C CA  . LEU A 1 540 ? 9.124   37.261  64.682  1.00 89.60  ?  521 LEU A CA  1 
ATOM   2786 C C   . LEU A 1 540 ? 9.366   37.917  63.336  1.00 92.30  ?  521 LEU A C   1 
ATOM   2787 O O   . LEU A 1 540 ? 10.366  38.627  63.175  1.00 92.74  ?  521 LEU A O   1 
ATOM   2788 C CB  . LEU A 1 540 ? 8.818   38.335  65.730  1.00 95.12  ?  521 LEU A CB  1 
ATOM   2789 C CG  . LEU A 1 540 ? 8.310   37.907  67.112  1.00 94.38  ?  521 LEU A CG  1 
ATOM   2790 C CD1 . LEU A 1 540 ? 8.691   38.938  68.147  1.00 92.11  ?  521 LEU A CD1 1 
ATOM   2791 C CD2 . LEU A 1 540 ? 6.816   37.641  67.136  1.00 95.99  ?  521 LEU A CD2 1 
ATOM   2792 N N   . SER A 1 541 ? 8.453   37.707  62.389  1.00 85.81  ?  522 SER A N   1 
ATOM   2793 C CA  . SER A 1 541 ? 8.582   38.419  61.128  1.00 96.23  ?  522 SER A CA  1 
ATOM   2794 C C   . SER A 1 541 ? 8.207   39.892  61.303  1.00 97.22  ?  522 SER A C   1 
ATOM   2795 O O   . SER A 1 541 ? 7.628   40.288  62.310  1.00 98.13  ?  522 SER A O   1 
ATOM   2796 C CB  . SER A 1 541 ? 7.710   37.774  60.058  1.00 104.15 ?  522 SER A CB  1 
ATOM   2797 O OG  . SER A 1 541 ? 6.356   38.144  60.186  1.00 99.31  ?  522 SER A OG  1 
ATOM   2798 N N   . SER A 1 542 ? 8.532   40.714  60.295  1.00 97.68  ?  523 SER A N   1 
ATOM   2799 C CA  . SER A 1 542 ? 8.174   42.133  60.355  1.00 105.10 ?  523 SER A CA  1 
ATOM   2800 C C   . SER A 1 542 ? 6.677   42.314  60.593  1.00 102.91 ?  523 SER A C   1 
ATOM   2801 O O   . SER A 1 542 ? 6.245   43.307  61.201  1.00 103.10 ?  523 SER A O   1 
ATOM   2802 C CB  . SER A 1 542 ? 8.581   42.854  59.072  1.00 103.65 ?  523 SER A CB  1 
ATOM   2803 O OG  . SER A 1 542 ? 7.922   42.296  57.956  1.00 111.11 ?  523 SER A OG  1 
ATOM   2804 N N   . ARG A 1 543 ? 5.868   41.376  60.104  1.00 98.92  ?  524 ARG A N   1 
ATOM   2805 C CA  . ARG A 1 543 ? 4.451   41.427  60.413  1.00 97.14  ?  524 ARG A CA  1 
ATOM   2806 C C   . ARG A 1 543 ? 4.206   41.121  61.887  1.00 97.14  ?  524 ARG A C   1 
ATOM   2807 O O   . ARG A 1 543 ? 3.309   41.704  62.500  1.00 95.15  ?  524 ARG A O   1 
ATOM   2808 C CB  . ARG A 1 543 ? 3.655   40.457  59.535  1.00 100.16 ?  524 ARG A CB  1 
ATOM   2809 C CG  . ARG A 1 543 ? 2.189   40.644  59.742  1.00 103.85 ?  524 ARG A CG  1 
ATOM   2810 C CD  . ARG A 1 543 ? 1.299   39.665  59.024  1.00 105.90 ?  524 ARG A CD  1 
ATOM   2811 N NE  . ARG A 1 543 ? 0.591   40.331  57.940  1.00 114.00 ?  524 ARG A NE  1 
ATOM   2812 C CZ  . ARG A 1 543 ? -0.561  39.909  57.424  1.00 121.83 ?  524 ARG A CZ  1 
ATOM   2813 N NH1 . ARG A 1 543 ? -1.141  40.590  56.432  1.00 121.97 ?  524 ARG A NH1 1 
ATOM   2814 N NH2 . ARG A 1 543 ? -1.148  38.821  57.933  1.00 116.90 ?  524 ARG A NH2 1 
ATOM   2815 N N   . ASP A 1 544 ? 4.964   40.188  62.486  1.00 98.75  ?  525 ASP A N   1 
ATOM   2816 C CA  . ASP A 1 544 ? 4.532   39.762  63.802  1.00 96.25  ?  525 ASP A CA  1 
ATOM   2817 C C   . ASP A 1 544 ? 4.973   40.816  64.797  1.00 92.68  ?  525 ASP A C   1 
ATOM   2818 O O   . ASP A 1 544 ? 4.272   41.095  65.765  1.00 93.16  ?  525 ASP A O   1 
ATOM   2819 C CB  . ASP A 1 544 ? 5.091   38.411  64.274  1.00 99.88  ?  525 ASP A CB  1 
ATOM   2820 C CG  . ASP A 1 544 ? 5.042   37.272  63.269  1.00 110.11 ?  525 ASP A CG  1 
ATOM   2821 O OD1 . ASP A 1 544 ? 4.422   37.490  62.131  1.00 113.86 ?  525 ASP A OD1 1 
ATOM   2822 O OD2 . ASP A 1 544 ? 5.376   36.118  63.766  1.00 114.28 ?  525 ASP A OD2 1 
ATOM   2823 N N   . ARG A 1 545 ? 6.135   41.432  64.541  1.00 95.31  ?  526 ARG A N   1 
ATOM   2824 C CA  . ARG A 1 545 ? 6.628   42.541  65.351  1.00 92.76  ?  526 ARG A CA  1 
ATOM   2825 C C   . ARG A 1 545 ? 5.710   43.759  65.263  1.00 85.67  ?  526 ARG A C   1 
ATOM   2826 O O   . ARG A 1 545 ? 5.580   44.506  66.238  1.00 89.18  ?  526 ARG A O   1 
ATOM   2827 C CB  . ARG A 1 545 ? 8.068   42.901  64.935  1.00 93.95  ?  526 ARG A CB  1 
ATOM   2828 C CG  . ARG A 1 545 ? 8.757   43.999  65.752  1.00 95.09  ?  526 ARG A CG  1 
ATOM   2829 C CD  . ARG A 1 545 ? 9.325   43.457  67.090  1.00 93.51  ?  526 ARG A CD  1 
ATOM   2830 N NE  . ARG A 1 545 ? 10.134  44.370  67.943  1.00 101.41 ?  526 ARG A NE  1 
ATOM   2831 C CZ  . ARG A 1 545 ? 9.817   45.613  68.352  1.00 102.55 ?  526 ARG A CZ  1 
ATOM   2832 N NH1 . ARG A 1 545 ? 8.685   46.205  67.979  1.00 94.52  ?  526 ARG A NH1 1 
ATOM   2833 N NH2 . ARG A 1 545 ? 10.654  46.286  69.151  1.00 99.57  ?  526 ARG A NH2 1 
ATOM   2834 N N   . GLN A 1 546 ? 5.031   43.961  64.141  1.00 81.76  ?  527 GLN A N   1 
ATOM   2835 C CA  . GLN A 1 546 ? 4.083   45.069  64.100  1.00 82.97  ?  527 GLN A CA  1 
ATOM   2836 C C   . GLN A 1 546 ? 2.854   44.803  64.962  1.00 83.32  ?  527 GLN A C   1 
ATOM   2837 O O   . GLN A 1 546 ? 2.312   45.737  65.549  1.00 89.01  ?  527 GLN A O   1 
ATOM   2838 C CB  . GLN A 1 546 ? 3.642   45.381  62.676  1.00 87.87  ?  527 GLN A CB  1 
ATOM   2839 C CG  . GLN A 1 546 ? 4.626   46.214  61.861  1.00 101.42 ?  527 GLN A CG  1 
ATOM   2840 C CD  . GLN A 1 546 ? 4.498   45.953  60.357  1.00 101.67 ?  527 GLN A CD  1 
ATOM   2841 O OE1 . GLN A 1 546 ? 3.425   45.587  59.853  1.00 99.74  ?  527 GLN A OE1 1 
ATOM   2842 N NE2 . GLN A 1 546 ? 5.610   46.087  59.649  1.00 102.47 ?  527 GLN A NE2 1 
ATOM   2843 N N   . ILE A 1 547 ? 2.385   43.565  65.058  1.00 82.26  ?  528 ILE A N   1 
ATOM   2844 C CA  . ILE A 1 547 ? 1.272   43.305  65.969  1.00 86.05  ?  528 ILE A CA  1 
ATOM   2845 C C   . ILE A 1 547 ? 1.748   43.308  67.424  1.00 83.02  ?  528 ILE A C   1 
ATOM   2846 O O   . ILE A 1 547 ? 1.016   43.724  68.331  1.00 81.51  ?  528 ILE A O   1 
ATOM   2847 C CB  . ILE A 1 547 ? 0.561   41.985  65.592  1.00 89.91  ?  528 ILE A CB  1 
ATOM   2848 C CG1 . ILE A 1 547 ? -0.112  42.113  64.222  1.00 91.12  ?  528 ILE A CG1 1 
ATOM   2849 C CG2 . ILE A 1 547 ? -0.436  41.548  66.684  1.00 85.12  ?  528 ILE A CG2 1 
ATOM   2850 C CD1 . ILE A 1 547 ? -0.590  40.831  63.659  1.00 90.89  ?  528 ILE A CD1 1 
ATOM   2851 N N   . LEU A 1 548 ? 2.966   42.829  67.675  1.00 79.26  ?  529 LEU A N   1 
ATOM   2852 C CA  . LEU A 1 548 ? 3.552   42.976  68.997  1.00 73.48  ?  529 LEU A CA  1 
ATOM   2853 C C   . LEU A 1 548 ? 3.677   44.446  69.379  1.00 82.83  ?  529 LEU A C   1 
ATOM   2854 O O   . LEU A 1 548 ? 3.521   44.805  70.553  1.00 80.22  ?  529 LEU A O   1 
ATOM   2855 C CB  . LEU A 1 548 ? 4.915   42.310  69.033  1.00 72.17  ?  529 LEU A CB  1 
ATOM   2856 C CG  . LEU A 1 548 ? 5.652   42.402  70.357  1.00 73.53  ?  529 LEU A CG  1 
ATOM   2857 C CD1 . LEU A 1 548 ? 4.831   41.760  71.456  1.00 70.75  ?  529 LEU A CD1 1 
ATOM   2858 C CD2 . LEU A 1 548 ? 7.020   41.751  70.221  1.00 69.23  ?  529 LEU A CD2 1 
ATOM   2859 N N   . ASP A 1 549 ? 3.949   45.312  68.401  1.00 81.23  ?  530 ASP A N   1 
ATOM   2860 C CA  . ASP A 1 549 ? 4.052   46.732  68.686  1.00 72.68  ?  530 ASP A CA  1 
ATOM   2861 C C   . ASP A 1 549 ? 2.719   47.313  69.100  1.00 73.87  ?  530 ASP A C   1 
ATOM   2862 O O   . ASP A 1 549 ? 2.680   48.325  69.797  1.00 79.93  ?  530 ASP A O   1 
ATOM   2863 C CB  . ASP A 1 549 ? 4.576   47.473  67.470  1.00 74.30  ?  530 ASP A CB  1 
ATOM   2864 C CG  . ASP A 1 549 ? 6.062   47.660  67.518  1.00 81.70  ?  530 ASP A CG  1 
ATOM   2865 O OD1 . ASP A 1 549 ? 6.662   47.395  68.590  1.00 78.68  ?  530 ASP A OD1 1 
ATOM   2866 O OD2 . ASP A 1 549 ? 6.626   48.075  66.483  1.00 88.25  ?  530 ASP A OD2 1 
ATOM   2867 N N   . TRP A 1 550 ? 1.619   46.719  68.673  1.00 73.88  ?  531 TRP A N   1 
ATOM   2868 C CA  . TRP A 1 550 ? 0.341   47.235  69.125  1.00 71.68  ?  531 TRP A CA  1 
ATOM   2869 C C   . TRP A 1 550 ? 0.136   46.924  70.595  1.00 74.71  ?  531 TRP A C   1 
ATOM   2870 O O   . TRP A 1 550 ? -0.331  47.778  71.356  1.00 75.99  ?  531 TRP A O   1 
ATOM   2871 C CB  . TRP A 1 550 ? -0.788  46.658  68.291  1.00 73.62  ?  531 TRP A CB  1 
ATOM   2872 C CG  . TRP A 1 550 ? -2.122  47.164  68.682  1.00 71.26  ?  531 TRP A CG  1 
ATOM   2873 C CD1 . TRP A 1 550 ? -2.832  48.147  68.061  1.00 74.88  ?  531 TRP A CD1 1 
ATOM   2874 C CD2 . TRP A 1 550 ? -2.935  46.700  69.769  1.00 68.74  ?  531 TRP A CD2 1 
ATOM   2875 N NE1 . TRP A 1 550 ? -4.036  48.330  68.701  1.00 77.14  ?  531 TRP A NE1 1 
ATOM   2876 C CE2 . TRP A 1 550 ? -4.123  47.455  69.752  1.00 71.42  ?  531 TRP A CE2 1 
ATOM   2877 C CE3 . TRP A 1 550 ? -2.769  45.723  70.760  1.00 75.69  ?  531 TRP A CE3 1 
ATOM   2878 C CZ2 . TRP A 1 550 ? -5.142  47.273  70.692  1.00 74.54  ?  531 TRP A CZ2 1 
ATOM   2879 C CZ3 . TRP A 1 550 ? -3.783  45.539  71.699  1.00 75.39  ?  531 TRP A CZ3 1 
ATOM   2880 C CH2 . TRP A 1 550 ? -4.954  46.309  71.657  1.00 73.52  ?  531 TRP A CH2 1 
ATOM   2881 N N   . HIS A 1 551 ? 0.471   45.707  71.015  1.00 73.88  ?  532 HIS A N   1 
ATOM   2882 C CA  . HIS A 1 551 ? 0.335   45.370  72.423  1.00 74.31  ?  532 HIS A CA  1 
ATOM   2883 C C   . HIS A 1 551 ? 1.262   46.233  73.282  1.00 75.68  ?  532 HIS A C   1 
ATOM   2884 O O   . HIS A 1 551 ? 0.959   46.496  74.450  1.00 73.73  ?  532 HIS A O   1 
ATOM   2885 C CB  . HIS A 1 551 ? 0.590   43.872  72.634  1.00 75.89  ?  532 HIS A CB  1 
ATOM   2886 C CG  . HIS A 1 551 ? -0.487  42.987  72.075  1.00 81.75  ?  532 HIS A CG  1 
ATOM   2887 N ND1 . HIS A 1 551 ? -1.511  42.482  72.845  1.00 87.87  ?  532 HIS A ND1 1 
ATOM   2888 C CD2 . HIS A 1 551 ? -0.701  42.521  70.821  1.00 82.86  ?  532 HIS A CD2 1 
ATOM   2889 C CE1 . HIS A 1 551 ? -2.307  41.741  72.093  1.00 89.39  ?  532 HIS A CE1 1 
ATOM   2890 N NE2 . HIS A 1 551 ? -1.839  41.750  70.859  1.00 88.58  ?  532 HIS A NE2 1 
ATOM   2891 N N   . PHE A 1 552 ? 2.372   46.709  72.712  1.00 72.08  ?  533 PHE A N   1 
ATOM   2892 C CA  . PHE A 1 552 ? 3.227   47.661  73.404  1.00 71.14  ?  533 PHE A CA  1 
ATOM   2893 C C   . PHE A 1 552 ? 2.618   49.060  73.424  1.00 72.85  ?  533 PHE A C   1 
ATOM   2894 O O   . PHE A 1 552 ? 2.794   49.806  74.394  1.00 63.15  ?  533 PHE A O   1 
ATOM   2895 C CB  . PHE A 1 552 ? 4.598   47.703  72.743  1.00 69.52  ?  533 PHE A CB  1 
ATOM   2896 C CG  . PHE A 1 552 ? 5.456   46.509  73.049  1.00 75.12  ?  533 PHE A CG  1 
ATOM   2897 C CD1 . PHE A 1 552 ? 5.276   45.790  74.218  1.00 74.55  ?  533 PHE A CD1 1 
ATOM   2898 C CD2 . PHE A 1 552 ? 6.446   46.093  72.148  1.00 76.45  ?  533 PHE A CD2 1 
ATOM   2899 C CE1 . PHE A 1 552 ? 6.091   44.682  74.496  1.00 78.62  ?  533 PHE A CE1 1 
ATOM   2900 C CE2 . PHE A 1 552 ? 7.249   44.996  72.413  1.00 68.07  ?  533 PHE A CE2 1 
ATOM   2901 C CZ  . PHE A 1 552 ? 7.079   44.290  73.585  1.00 73.89  ?  533 PHE A CZ  1 
ATOM   2902 N N   . ALA A 1 553 ? 1.904   49.442  72.371  1.00 73.34  ?  534 ALA A N   1 
ATOM   2903 C CA  . ALA A 1 553 ? 1.154   50.687  72.441  1.00 73.09  ?  534 ALA A CA  1 
ATOM   2904 C C   . ALA A 1 553 ? 0.102   50.623  73.541  1.00 73.59  ?  534 ALA A C   1 
ATOM   2905 O O   . ALA A 1 553 ? -0.037  51.566  74.320  1.00 78.35  ?  534 ALA A O   1 
ATOM   2906 C CB  . ALA A 1 553 ? 0.509   51.006  71.091  1.00 73.04  ?  534 ALA A CB  1 
ATOM   2907 N N   . ASN A 1 554 ? -0.640  49.512  73.629  1.00 75.02  ?  535 ASN A N   1 
ATOM   2908 C CA  . ASN A 1 554 ? -1.651  49.380  74.676  1.00 70.83  ?  535 ASN A CA  1 
ATOM   2909 C C   . ASN A 1 554 ? -1.046  49.575  76.049  1.00 66.90  ?  535 ASN A C   1 
ATOM   2910 O O   . ASN A 1 554 ? -1.705  50.090  76.951  1.00 73.58  ?  535 ASN A O   1 
ATOM   2911 C CB  . ASN A 1 554 ? -2.325  48.010  74.626  1.00 72.40  ?  535 ASN A CB  1 
ATOM   2912 C CG  . ASN A 1 554 ? -3.724  48.037  75.200  1.00 68.49  ?  535 ASN A CG  1 
ATOM   2913 O OD1 . ASN A 1 554 ? -4.496  48.940  74.916  1.00 72.73  ?  535 ASN A OD1 1 
ATOM   2914 N ND2 . ASN A 1 554 ? -4.044  47.065  76.037  1.00 75.08  ?  535 ASN A ND2 1 
ATOM   2915 N N   . LEU A 1 555 ? 0.192   49.129  76.236  1.00 63.22  ?  536 LEU A N   1 
ATOM   2916 C CA  . LEU A 1 555 ? 0.841   49.246  77.530  1.00 63.61  ?  536 LEU A CA  1 
ATOM   2917 C C   . LEU A 1 555 ? 1.322   50.675  77.754  1.00 71.10  ?  536 LEU A C   1 
ATOM   2918 O O   . LEU A 1 555 ? 1.224   51.209  78.863  1.00 73.70  ?  536 LEU A O   1 
ATOM   2919 C CB  . LEU A 1 555 ? 2.000   48.265  77.608  1.00 59.71  ?  536 LEU A CB  1 
ATOM   2920 C CG  . LEU A 1 555 ? 2.619   48.111  78.977  1.00 68.11  ?  536 LEU A CG  1 
ATOM   2921 C CD1 . LEU A 1 555 ? 1.611   47.427  79.852  1.00 69.96  ?  536 LEU A CD1 1 
ATOM   2922 C CD2 . LEU A 1 555 ? 3.939   47.343  78.920  1.00 68.39  ?  536 LEU A CD2 1 
ATOM   2923 N N   . GLU A 1 556 ? 1.832   51.309  76.706  1.00 67.18  ?  537 GLU A N   1 
ATOM   2924 C CA  . GLU A 1 556 ? 2.191   52.712  76.784  1.00 66.13  ?  537 GLU A CA  1 
ATOM   2925 C C   . GLU A 1 556 ? 0.970   53.582  77.039  1.00 72.55  ?  537 GLU A C   1 
ATOM   2926 O O   . GLU A 1 556 ? 1.068   54.607  77.734  1.00 71.02  ?  537 GLU A O   1 
ATOM   2927 C CB  . GLU A 1 556 ? 2.910   53.130  75.503  1.00 67.20  ?  537 GLU A CB  1 
ATOM   2928 C CG  . GLU A 1 556 ? 4.365   52.707  75.558  1.00 65.82  ?  537 GLU A CG  1 
ATOM   2929 C CD  . GLU A 1 556 ? 5.145   52.924  74.279  1.00 68.86  ?  537 GLU A CD  1 
ATOM   2930 O OE1 . GLU A 1 556 ? 4.542   53.130  73.187  1.00 69.44  ?  537 GLU A OE1 1 
ATOM   2931 O OE2 . GLU A 1 556 ? 6.391   52.872  74.391  1.00 66.32  ?  537 GLU A OE2 1 
ATOM   2932 N N   . PHE A 1 557 ? -0.184  53.202  76.481  1.00 70.25  ?  538 PHE A N   1 
ATOM   2933 C CA  . PHE A 1 557 ? -1.431  53.882  76.823  1.00 72.18  ?  538 PHE A CA  1 
ATOM   2934 C C   . PHE A 1 557 ? -1.751  53.770  78.313  1.00 71.17  ?  538 PHE A C   1 
ATOM   2935 O O   . PHE A 1 557 ? -1.996  54.777  78.978  1.00 76.28  ?  538 PHE A O   1 
ATOM   2936 C CB  . PHE A 1 557 ? -2.580  53.339  75.970  1.00 76.34  ?  538 PHE A CB  1 
ATOM   2937 C CG  . PHE A 1 557 ? -3.918  53.418  76.635  1.00 81.25  ?  538 PHE A CG  1 
ATOM   2938 C CD1 . PHE A 1 557 ? -4.450  54.638  77.018  1.00 85.69  ?  538 PHE A CD1 1 
ATOM   2939 C CD2 . PHE A 1 557 ? -4.660  52.264  76.873  1.00 79.02  ?  538 PHE A CD2 1 
ATOM   2940 C CE1 . PHE A 1 557 ? -5.684  54.705  77.672  1.00 88.36  ?  538 PHE A CE1 1 
ATOM   2941 C CE2 . PHE A 1 557 ? -5.909  52.323  77.497  1.00 83.10  ?  538 PHE A CE2 1 
ATOM   2942 C CZ  . PHE A 1 557 ? -6.421  53.550  77.898  1.00 86.18  ?  538 PHE A CZ  1 
ATOM   2943 N N   . ALA A 1 558 ? -1.729  52.559  78.864  1.00 71.51  ?  539 ALA A N   1 
ATOM   2944 C CA  . ALA A 1 558 ? -2.155  52.373  80.248  1.00 71.44  ?  539 ALA A CA  1 
ATOM   2945 C C   . ALA A 1 558 ? -1.274  53.134  81.245  1.00 71.59  ?  539 ALA A C   1 
ATOM   2946 O O   . ALA A 1 558 ? -1.738  53.515  82.322  1.00 73.95  ?  539 ALA A O   1 
ATOM   2947 C CB  . ALA A 1 558 ? -2.162  50.887  80.576  1.00 65.27  ?  539 ALA A CB  1 
ATOM   2948 N N   . ASN A 1 559 ? -0.010  53.340  80.919  1.00 66.19  ?  540 ASN A N   1 
ATOM   2949 C CA  . ASN A 1 559 ? 0.907   54.034  81.789  1.00 61.75  ?  540 ASN A CA  1 
ATOM   2950 C C   . ASN A 1 559 ? 1.208   55.419  81.282  1.00 63.57  ?  540 ASN A C   1 
ATOM   2951 O O   . ASN A 1 559 ? 2.087   56.088  81.824  1.00 64.32  ?  540 ASN A O   1 
ATOM   2952 C CB  . ASN A 1 559 ? 2.191   53.229  81.945  1.00 57.83  ?  540 ASN A CB  1 
ATOM   2953 C CG  . ASN A 1 559 ? 1.952   51.949  82.630  1.00 65.72  ?  540 ASN A CG  1 
ATOM   2954 O OD1 . ASN A 1 559 ? 2.153   51.816  83.848  1.00 69.53  ?  540 ASN A OD1 1 
ATOM   2955 N ND2 . ASN A 1 559 ? 1.468   50.980  81.870  1.00 70.60  ?  540 ASN A ND2 1 
ATOM   2956 N N   . ALA A 1 560 ? 0.502   55.851  80.247  1.00 69.20  ?  541 ALA A N   1 
ATOM   2957 C CA  . ALA A 1 560 ? 0.661   57.174  79.630  1.00 68.79  ?  541 ALA A CA  1 
ATOM   2958 C C   . ALA A 1 560 ? 2.123   57.600  79.478  1.00 60.80  ?  541 ALA A C   1 
ATOM   2959 O O   . ALA A 1 560 ? 2.489   58.711  79.805  1.00 57.90  ?  541 ALA A O   1 
ATOM   2960 C CB  . ALA A 1 560 ? -0.114  58.224  80.414  1.00 64.84  ?  541 ALA A CB  1 
ATOM   2961 N N   . THR A 1 561 ? 2.965   56.721  78.952  1.00 65.50  ?  542 THR A N   1 
ATOM   2962 C CA  . THR A 1 561 ? 4.364   57.092  78.742  1.00 61.11  ?  542 THR A CA  1 
ATOM   2963 C C   . THR A 1 561 ? 5.075   56.018  77.925  1.00 64.05  ?  542 THR A C   1 
ATOM   2964 O O   . THR A 1 561 ? 4.717   54.842  78.012  1.00 59.95  ?  542 THR A O   1 
ATOM   2965 C CB  . THR A 1 561 ? 5.102   57.296  80.071  1.00 60.80  ?  542 THR A CB  1 
ATOM   2966 O OG1 . THR A 1 561 ? 6.466   57.656  79.809  1.00 63.11  ?  542 THR A OG1 1 
ATOM   2967 C CG2 . THR A 1 561 ? 5.069   56.027  80.931  1.00 54.08  ?  542 THR A CG2 1 
ATOM   2968 N N   . PRO A 1 562 ? 6.065   56.379  77.109  1.00 67.94  ?  543 PRO A N   1 
ATOM   2969 C CA  . PRO A 1 562 ? 6.875   55.354  76.447  1.00 64.80  ?  543 PRO A CA  1 
ATOM   2970 C C   . PRO A 1 562 ? 7.549   54.418  77.444  1.00 61.72  ?  543 PRO A C   1 
ATOM   2971 O O   . PRO A 1 562 ? 8.093   54.851  78.459  1.00 63.77  ?  543 PRO A O   1 
ATOM   2972 C CB  . PRO A 1 562 ? 7.907   56.176  75.664  1.00 66.31  ?  543 PRO A CB  1 
ATOM   2973 C CG  . PRO A 1 562 ? 7.719   57.585  76.094  1.00 61.02  ?  543 PRO A CG  1 
ATOM   2974 C CD  . PRO A 1 562 ? 6.320   57.706  76.531  1.00 61.48  ?  543 PRO A CD  1 
ATOM   2975 N N   . LEU A 1 563 ? 7.544   53.122  77.117  1.00 61.39  ?  544 LEU A N   1 
ATOM   2976 C CA  . LEU A 1 563 ? 8.169   52.121  77.973  1.00 62.29  ?  544 LEU A CA  1 
ATOM   2977 C C   . LEU A 1 563 ? 9.644   52.406  78.233  1.00 60.28  ?  544 LEU A C   1 
ATOM   2978 O O   . LEU A 1 563 ? 10.222  51.844  79.168  1.00 63.89  ?  544 LEU A O   1 
ATOM   2979 C CB  . LEU A 1 563 ? 7.983   50.725  77.359  1.00 60.35  ?  544 LEU A CB  1 
ATOM   2980 C CG  . LEU A 1 563 ? 6.577   50.377  76.845  1.00 63.86  ?  544 LEU A CG  1 
ATOM   2981 C CD1 . LEU A 1 563 ? 6.531   48.964  76.313  1.00 68.18  ?  544 LEU A CD1 1 
ATOM   2982 C CD2 . LEU A 1 563 ? 5.496   50.535  77.910  1.00 66.87  ?  544 LEU A CD2 1 
ATOM   2983 N N   . SER A 1 564 ? 10.267  53.281  77.462  1.00 59.21  ?  545 SER A N   1 
ATOM   2984 C CA  . SER A 1 564 ? 11.661  53.585  77.733  1.00 59.75  ?  545 SER A CA  1 
ATOM   2985 C C   . SER A 1 564 ? 11.848  54.412  78.989  1.00 67.43  ?  545 SER A C   1 
ATOM   2986 O O   . SER A 1 564 ? 12.991  54.532  79.451  1.00 69.45  ?  545 SER A O   1 
ATOM   2987 C CB  . SER A 1 564 ? 12.250  54.294  76.523  1.00 64.81  ?  545 SER A CB  1 
ATOM   2988 O OG  . SER A 1 564 ? 11.407  55.360  76.125  1.00 75.81  ?  545 SER A OG  1 
ATOM   2989 N N   . THR A 1 565 ? 10.756  54.965  79.547  1.00 61.92  ?  546 THR A N   1 
ATOM   2990 C CA  . THR A 1 565 ? 10.800  55.774  80.756  1.00 63.71  ?  546 THR A CA  1 
ATOM   2991 C C   . THR A 1 565 ? 10.350  55.035  82.019  1.00 63.22  ?  546 THR A C   1 
ATOM   2992 O O   . THR A 1 565 ? 10.741  55.451  83.116  1.00 61.25  ?  546 THR A O   1 
ATOM   2993 C CB  . THR A 1 565 ? 9.942   57.035  80.587  1.00 62.55  ?  546 THR A CB  1 
ATOM   2994 O OG1 . THR A 1 565 ? 8.550   56.692  80.630  1.00 63.27  ?  546 THR A OG1 1 
ATOM   2995 C CG2 . THR A 1 565 ? 10.230  57.688  79.274  1.00 62.02  ?  546 THR A CG2 1 
ATOM   2996 N N   . LEU A 1 566 ? 9.559   53.956  81.904  1.00 63.80  ?  547 LEU A N   1 
ATOM   2997 C CA  . LEU A 1 566 ? 9.075   53.220  83.079  1.00 61.98  ?  547 LEU A CA  1 
ATOM   2998 C C   . LEU A 1 566 ? 10.218  52.519  83.814  1.00 66.00  ?  547 LEU A C   1 
ATOM   2999 O O   . LEU A 1 566 ? 11.102  51.923  83.194  1.00 67.14  ?  547 LEU A O   1 
ATOM   3000 C CB  . LEU A 1 566 ? 8.018   52.189  82.672  1.00 56.01  ?  547 LEU A CB  1 
ATOM   3001 C CG  . LEU A 1 566 ? 6.656   52.745  82.264  1.00 60.66  ?  547 LEU A CG  1 
ATOM   3002 C CD1 . LEU A 1 566 ? 5.674   51.675  81.828  1.00 56.50  ?  547 LEU A CD1 1 
ATOM   3003 C CD2 . LEU A 1 566 ? 6.086   53.499  83.430  1.00 59.69  ?  547 LEU A CD2 1 
ATOM   3004 N N   . SER A 1 567 ? 10.216  52.607  85.143  1.00 63.30  ?  548 SER A N   1 
ATOM   3005 C CA  . SER A 1 567 ? 11.171  51.841  85.938  1.00 65.67  ?  548 SER A CA  1 
ATOM   3006 C C   . SER A 1 567 ? 10.893  50.356  85.789  1.00 69.87  ?  548 SER A C   1 
ATOM   3007 O O   . SER A 1 567 ? 9.749   49.922  85.946  1.00 69.82  ?  548 SER A O   1 
ATOM   3008 C CB  . SER A 1 567 ? 11.078  52.227  87.410  1.00 66.45  ?  548 SER A CB  1 
ATOM   3009 O OG  . SER A 1 567 ? 11.811  51.342  88.231  1.00 64.91  ?  548 SER A OG  1 
ATOM   3010 N N   . LEU A 1 568 ? 11.931  49.568  85.488  1.00 70.50  ?  549 LEU A N   1 
ATOM   3011 C CA  . LEU A 1 568 ? 11.708  48.128  85.369  1.00 70.52  ?  549 LEU A CA  1 
ATOM   3012 C C   . LEU A 1 568 ? 11.325  47.532  86.711  1.00 67.62  ?  549 LEU A C   1 
ATOM   3013 O O   . LEU A 1 568 ? 10.376  46.744  86.794  1.00 65.87  ?  549 LEU A O   1 
ATOM   3014 C CB  . LEU A 1 568 ? 12.945  47.415  84.808  1.00 73.60  ?  549 LEU A CB  1 
ATOM   3015 C CG  . LEU A 1 568 ? 12.990  45.880  84.905  1.00 69.56  ?  549 LEU A CG  1 
ATOM   3016 C CD1 . LEU A 1 568 ? 11.990  45.221  83.959  1.00 66.67  ?  549 LEU A CD1 1 
ATOM   3017 C CD2 . LEU A 1 568 ? 14.383  45.388  84.616  1.00 72.18  ?  549 LEU A CD2 1 
ATOM   3018 N N   . LYS A 1 569 ? 12.021  47.933  87.780  1.00 66.27  ?  550 LYS A N   1 
ATOM   3019 C CA  . LYS A 1 569 ? 11.736  47.349  89.084  1.00 67.07  ?  550 LYS A CA  1 
ATOM   3020 C C   . LYS A 1 569 ? 10.304  47.626  89.525  1.00 71.43  ?  550 LYS A C   1 
ATOM   3021 O O   . LYS A 1 569 ? 9.608   46.709  89.976  1.00 77.19  ?  550 LYS A O   1 
ATOM   3022 C CB  . LYS A 1 569 ? 12.734  47.839  90.129  1.00 61.28  ?  550 LYS A CB  1 
ATOM   3023 C CG  . LYS A 1 569 ? 12.875  46.845  91.264  1.00 78.51  ?  550 LYS A CG  1 
ATOM   3024 C CD  . LYS A 1 569 ? 13.855  47.262  92.383  1.00 87.18  ?  550 LYS A CD  1 
ATOM   3025 C CE  . LYS A 1 569 ? 15.326  47.049  92.021  1.00 91.26  ?  550 LYS A CE  1 
ATOM   3026 N NZ  . LYS A 1 569 ? 16.229  47.107  93.221  1.00 90.11  ?  550 LYS A NZ  1 
ATOM   3027 N N   . HIS A 1 570 ? 9.818   48.867  89.343  1.00 72.35  ?  551 HIS A N   1 
ATOM   3028 C CA  . HIS A 1 570 ? 8.639   49.336  90.066  1.00 71.99  ?  551 HIS A CA  1 
ATOM   3029 C C   . HIS A 1 570 ? 7.420   49.677  89.224  1.00 70.31  ?  551 HIS A C   1 
ATOM   3030 O O   . HIS A 1 570 ? 6.375   49.983  89.801  1.00 75.81  ?  551 HIS A O   1 
ATOM   3031 C CB  . HIS A 1 570 ? 8.989   50.583  90.888  1.00 65.90  ?  551 HIS A CB  1 
ATOM   3032 C CG  . HIS A 1 570 ? 10.151  50.397  91.805  1.00 68.53  ?  551 HIS A CG  1 
ATOM   3033 N ND1 . HIS A 1 570 ? 10.066  49.678  92.978  1.00 71.88  ?  551 HIS A ND1 1 
ATOM   3034 C CD2 . HIS A 1 570 ? 11.423  50.860  91.740  1.00 70.21  ?  551 HIS A CD2 1 
ATOM   3035 C CE1 . HIS A 1 570 ? 11.236  49.702  93.594  1.00 70.65  ?  551 HIS A CE1 1 
ATOM   3036 N NE2 . HIS A 1 570 ? 12.076  50.418  92.868  1.00 71.53  ?  551 HIS A NE2 1 
ATOM   3037 N N   . TRP A 1 571 ? 7.514   49.681  87.901  1.00 68.71  ?  552 TRP A N   1 
ATOM   3038 C CA  . TRP A 1 571 ? 6.407   50.179  87.089  1.00 67.92  ?  552 TRP A CA  1 
ATOM   3039 C C   . TRP A 1 571 ? 5.062   49.547  87.448  1.00 73.58  ?  552 TRP A C   1 
ATOM   3040 O O   . TRP A 1 571 ? 4.008   50.160  87.223  1.00 72.85  ?  552 TRP A O   1 
ATOM   3041 C CB  . TRP A 1 571 ? 6.729   49.944  85.610  1.00 70.19  ?  552 TRP A CB  1 
ATOM   3042 C CG  . TRP A 1 571 ? 6.489   48.535  85.133  1.00 75.01  ?  552 TRP A CG  1 
ATOM   3043 C CD1 . TRP A 1 571 ? 7.360   47.467  85.203  1.00 69.34  ?  552 TRP A CD1 1 
ATOM   3044 C CD2 . TRP A 1 571 ? 5.300   48.041  84.506  1.00 72.37  ?  552 TRP A CD2 1 
ATOM   3045 N NE1 . TRP A 1 571 ? 6.772   46.358  84.660  1.00 68.12  ?  552 TRP A NE1 1 
ATOM   3046 C CE2 . TRP A 1 571 ? 5.514   46.678  84.222  1.00 65.89  ?  552 TRP A CE2 1 
ATOM   3047 C CE3 . TRP A 1 571 ? 4.075   48.621  84.160  1.00 72.69  ?  552 TRP A CE3 1 
ATOM   3048 C CZ2 . TRP A 1 571 ? 4.556   45.888  83.610  1.00 59.60  ?  552 TRP A CZ2 1 
ATOM   3049 C CZ3 . TRP A 1 571 ? 3.120   47.828  83.551  1.00 75.29  ?  552 TRP A CZ3 1 
ATOM   3050 C CH2 . TRP A 1 571 ? 3.370   46.473  83.282  1.00 64.24  ?  552 TRP A CH2 1 
ATOM   3051 N N   . ASP A 1 572 ? 5.074   48.341  88.013  1.00 78.24  ?  553 ASP A N   1 
ATOM   3052 C CA  . ASP A 1 572 ? 3.852   47.625  88.349  1.00 82.11  ?  553 ASP A CA  1 
ATOM   3053 C C   . ASP A 1 572 ? 3.709   47.433  89.850  1.00 87.53  ?  553 ASP A C   1 
ATOM   3054 O O   . ASP A 1 572 ? 3.009   46.514  90.281  1.00 93.55  ?  553 ASP A O   1 
ATOM   3055 C CB  . ASP A 1 572 ? 3.803   46.265  87.642  1.00 85.05  ?  553 ASP A CB  1 
ATOM   3056 C CG  . ASP A 1 572 ? 5.024   45.379  87.960  1.00 89.13  ?  553 ASP A CG  1 
ATOM   3057 O OD1 . ASP A 1 572 ? 4.996   44.184  87.567  1.00 89.62  ?  553 ASP A OD1 1 
ATOM   3058 O OD2 . ASP A 1 572 ? 6.020   45.881  88.563  1.00 84.58  ?  553 ASP A OD2 1 
ATOM   3059 N N   . GLN A 1 573 ? 4.373   48.271  90.658  1.00 90.10  ?  554 GLN A N   1 
ATOM   3060 C CA  . GLN A 1 573 ? 4.313   48.149  92.117  1.00 86.41  ?  554 GLN A CA  1 
ATOM   3061 C C   . GLN A 1 573 ? 2.900   48.289  92.675  1.00 88.82  ?  554 GLN A C   1 
ATOM   3062 O O   . GLN A 1 573 ? 2.673   47.903  93.824  1.00 94.98  ?  554 GLN A O   1 
ATOM   3063 C CB  . GLN A 1 573 ? 5.247   49.170  92.767  1.00 76.68  ?  554 GLN A CB  1 
ATOM   3064 C CG  . GLN A 1 573 ? 4.973   50.625  92.364  1.00 87.60  ?  554 GLN A CG  1 
ATOM   3065 C CD  . GLN A 1 573 ? 4.246   51.453  93.416  1.00 85.14  ?  554 GLN A CD  1 
ATOM   3066 O OE1 . GLN A 1 573 ? 4.539   51.356  94.616  1.00 83.66  ?  554 GLN A OE1 1 
ATOM   3067 N NE2 . GLN A 1 573 ? 3.295   52.280  92.968  1.00 76.74  ?  554 GLN A NE2 1 
ATOM   3068 N N   . ASP A 1 574 ? 1.943   48.773  91.884  1.00 92.77  ?  555 ASP A N   1 
ATOM   3069 C CA  . ASP A 1 574 ? 0.563   48.960  92.315  1.00 94.22  ?  555 ASP A CA  1 
ATOM   3070 C C   . ASP A 1 574 ? -0.395  47.857  91.831  1.00 100.42 ?  555 ASP A C   1 
ATOM   3071 O O   . ASP A 1 574 ? -1.600  47.951  92.100  1.00 97.07  ?  555 ASP A O   1 
ATOM   3072 C CB  . ASP A 1 574 ? 0.069   50.371  91.893  1.00 92.61  ?  555 ASP A CB  1 
ATOM   3073 C CG  . ASP A 1 574 ? -0.144  50.552  90.356  1.00 96.02  ?  555 ASP A CG  1 
ATOM   3074 O OD1 . ASP A 1 574 ? 0.783   50.287  89.555  1.00 102.69 ?  555 ASP A OD1 1 
ATOM   3075 O OD2 . ASP A 1 574 ? -1.225  51.043  89.951  1.00 96.74  ?  555 ASP A OD2 1 
ATOM   3076 N N   . ASP A 1 575 ? 0.107   46.796  91.160  1.00 106.11 ?  556 ASP A N   1 
ATOM   3077 C CA  . ASP A 1 575 ? -0.775  45.748  90.619  1.00 105.61 ?  556 ASP A CA  1 
ATOM   3078 C C   . ASP A 1 575 ? -1.416  44.892  91.708  1.00 103.59 ?  556 ASP A C   1 
ATOM   3079 O O   . ASP A 1 575 ? -2.450  44.263  91.452  1.00 103.98 ?  556 ASP A O   1 
ATOM   3080 C CB  . ASP A 1 575 ? -0.032  44.814  89.638  1.00 103.04 ?  556 ASP A CB  1 
ATOM   3081 C CG  . ASP A 1 575 ? 0.116   45.414  88.219  1.00 116.41 ?  556 ASP A CG  1 
ATOM   3082 O OD1 . ASP A 1 575 ? -0.235  46.605  88.004  1.00 116.41 ?  556 ASP A OD1 1 
ATOM   3083 O OD2 . ASP A 1 575 ? 0.570   44.676  87.306  1.00 114.45 ?  556 ASP A OD2 1 
ATOM   3084 N N   . ASP A 1 576 ? -0.829  44.854  92.910  1.00 98.20  ?  557 ASP A N   1 
ATOM   3085 C CA  . ASP A 1 576 ? -1.360  44.040  93.995  1.00 96.89  ?  557 ASP A CA  1 
ATOM   3086 C C   . ASP A 1 576 ? -2.625  44.610  94.623  1.00 94.17  ?  557 ASP A C   1 
ATOM   3087 O O   . ASP A 1 576 ? -3.308  43.887  95.362  1.00 94.90  ?  557 ASP A O   1 
ATOM   3088 C CB  . ASP A 1 576 ? -0.293  43.852  95.075  1.00 100.91 ?  557 ASP A CB  1 
ATOM   3089 C CG  . ASP A 1 576 ? 0.576   42.628  94.826  1.00 118.14 ?  557 ASP A CG  1 
ATOM   3090 O OD1 . ASP A 1 576 ? 0.622   42.142  93.662  1.00 117.43 ?  557 ASP A OD1 1 
ATOM   3091 O OD2 . ASP A 1 576 ? 1.193   42.140  95.801  1.00 119.52 ?  557 ASP A OD2 1 
ATOM   3092 N N   . PHE A 1 577 ? -2.947  45.877  94.362  1.00 91.29  ?  558 PHE A N   1 
ATOM   3093 C CA  . PHE A 1 577 ? -4.121  46.530  94.926  1.00 81.60  ?  558 PHE A CA  1 
ATOM   3094 C C   . PHE A 1 577 ? -5.194  46.744  93.880  1.00 83.60  ?  558 PHE A C   1 
ATOM   3095 O O   . PHE A 1 577 ? -6.073  47.595  94.068  1.00 78.97  ?  558 PHE A O   1 
ATOM   3096 C CB  . PHE A 1 577 ? -3.754  47.866  95.550  1.00 77.34  ?  558 PHE A CB  1 
ATOM   3097 C CG  . PHE A 1 577 ? -2.655  47.788  96.568  1.00 76.08  ?  558 PHE A CG  1 
ATOM   3098 C CD1 . PHE A 1 577 ? -1.330  47.736  96.177  1.00 77.87  ?  558 PHE A CD1 1 
ATOM   3099 C CD2 . PHE A 1 577 ? -2.943  47.827  97.924  1.00 78.48  ?  558 PHE A CD2 1 
ATOM   3100 C CE1 . PHE A 1 577 ? -0.314  47.687  97.113  1.00 74.80  ?  558 PHE A CE1 1 
ATOM   3101 C CE2 . PHE A 1 577 ? -1.922  47.787  98.871  1.00 71.94  ?  558 PHE A CE2 1 
ATOM   3102 C CZ  . PHE A 1 577 ? -0.608  47.712  98.457  1.00 68.22  ?  558 PHE A CZ  1 
ATOM   3103 N N   . GLU A 1 578 ? -5.107  46.002  92.775  1.00 85.28  ?  559 GLU A N   1 
ATOM   3104 C CA  . GLU A 1 578 ? -6.050  46.103  91.675  1.00 82.71  ?  559 GLU A CA  1 
ATOM   3105 C C   . GLU A 1 578 ? -7.451  45.777  92.189  1.00 73.48  ?  559 GLU A C   1 
ATOM   3106 O O   . GLU A 1 578 ? -7.632  44.973  93.103  1.00 69.22  ?  559 GLU A O   1 
ATOM   3107 C CB  . GLU A 1 578 ? -5.581  45.148  90.567  1.00 100.06 ?  559 GLU A CB  1 
ATOM   3108 C CG  . GLU A 1 578 ? -6.119  45.254  89.127  1.00 109.60 ?  559 GLU A CG  1 
ATOM   3109 C CD  . GLU A 1 578 ? -5.744  43.983  88.275  1.00 120.88 ?  559 GLU A CD  1 
ATOM   3110 O OE1 . GLU A 1 578 ? -5.223  42.968  88.841  1.00 104.98 ?  559 GLU A OE1 1 
ATOM   3111 O OE2 . GLU A 1 578 ? -5.965  44.010  87.037  1.00 126.89 ?  559 GLU A OE2 1 
ATOM   3112 N N   . PHE A 1 579 ? -8.445  46.456  91.649  1.00 76.36  ?  560 PHE A N   1 
ATOM   3113 C CA  . PHE A 1 579 ? -9.808  46.169  92.063  1.00 79.59  ?  560 PHE A CA  1 
ATOM   3114 C C   . PHE A 1 579 ? -10.342 44.932  91.340  1.00 82.02  ?  560 PHE A C   1 
ATOM   3115 O O   . PHE A 1 579 ? -9.969  44.641  90.196  1.00 87.87  ?  560 PHE A O   1 
ATOM   3116 C CB  . PHE A 1 579 ? -10.714 47.366  91.772  1.00 78.93  ?  560 PHE A CB  1 
ATOM   3117 C CG  . PHE A 1 579 ? -10.397 48.576  92.591  1.00 77.22  ?  560 PHE A CG  1 
ATOM   3118 C CD1 . PHE A 1 579 ? -9.932  48.446  93.884  1.00 77.08  ?  560 PHE A CD1 1 
ATOM   3119 C CD2 . PHE A 1 579 ? -10.552 49.854  92.063  1.00 74.22  ?  560 PHE A CD2 1 
ATOM   3120 C CE1 . PHE A 1 579 ? -9.633  49.570  94.636  1.00 74.40  ?  560 PHE A CE1 1 
ATOM   3121 C CE2 . PHE A 1 579 ? -10.262 50.973  92.815  1.00 69.45  ?  560 PHE A CE2 1 
ATOM   3122 C CZ  . PHE A 1 579 ? -9.797  50.832  94.094  1.00 68.24  ?  560 PHE A CZ  1 
ATOM   3123 N N   . THR A 1 580 ? -11.238 44.207  92.003  1.00 73.65  ?  561 THR A N   1 
ATOM   3124 C CA  . THR A 1 580 ? -11.875 43.084  91.330  1.00 78.72  ?  561 THR A CA  1 
ATOM   3125 C C   . THR A 1 580 ? -13.057 43.553  90.500  1.00 81.11  ?  561 THR A C   1 
ATOM   3126 O O   . THR A 1 580 ? -13.704 44.560  90.807  1.00 80.57  ?  561 THR A O   1 
ATOM   3127 C CB  . THR A 1 580 ? -12.386 42.027  92.298  1.00 74.55  ?  561 THR A CB  1 
ATOM   3128 O OG1 . THR A 1 580 ? -13.637 42.474  92.832  1.00 81.65  ?  561 THR A OG1 1 
ATOM   3129 C CG2 . THR A 1 580 ? -11.374 41.733  93.404  1.00 75.47  ?  561 THR A CG2 1 
ATOM   3130 N N   . GLY A 1 581 ? -13.329 42.800  89.437  1.00 80.09  ?  562 GLY A N   1 
ATOM   3131 C CA  . GLY A 1 581 ? -14.473 43.043  88.590  1.00 70.23  ?  562 GLY A CA  1 
ATOM   3132 C C   . GLY A 1 581 ? -14.081 43.650  87.263  1.00 81.14  ?  562 GLY A C   1 
ATOM   3133 O O   . GLY A 1 581 ? -12.908 43.898  86.949  1.00 81.83  ?  562 GLY A O   1 
ATOM   3134 N N   . SER A 1 582 ? -15.127 43.886  86.486  1.00 77.41  ?  563 SER A N   1 
ATOM   3135 C CA  . SER A 1 582 ? -15.037 44.398  85.135  1.00 82.34  ?  563 SER A CA  1 
ATOM   3136 C C   . SER A 1 582 ? -14.656 45.871  85.145  1.00 81.90  ?  563 SER A C   1 
ATOM   3137 O O   . SER A 1 582 ? -14.850 46.572  86.126  1.00 87.49  ?  563 SER A O   1 
ATOM   3138 C CB  . SER A 1 582 ? -16.392 44.225  84.444  1.00 95.11  ?  563 SER A CB  1 
ATOM   3139 O OG  . SER A 1 582 ? -16.749 42.859  84.383  1.00 109.39 ?  563 SER A OG  1 
ATOM   3140 N N   . HIS A 1 583 ? -14.131 46.343  84.037  1.00 79.67  ?  564 HIS A N   1 
ATOM   3141 C CA  . HIS A 1 583 ? -13.942 47.767  83.887  1.00 69.54  ?  564 HIS A CA  1 
ATOM   3142 C C   . HIS A 1 583 ? -15.174 48.354  83.210  1.00 83.07  ?  564 HIS A C   1 
ATOM   3143 O O   . HIS A 1 583 ? -15.892 47.658  82.490  1.00 92.20  ?  564 HIS A O   1 
ATOM   3144 C CB  . HIS A 1 583 ? -12.655 48.046  83.119  1.00 69.78  ?  564 HIS A CB  1 
ATOM   3145 C CG  . HIS A 1 583 ? -11.427 47.678  83.892  1.00 70.30  ?  564 HIS A CG  1 
ATOM   3146 N ND1 . HIS A 1 583 ? -10.160 48.084  83.526  1.00 68.30  ?  564 HIS A ND1 1 
ATOM   3147 C CD2 . HIS A 1 583 ? -11.282 46.974  85.042  1.00 69.55  ?  564 HIS A CD2 1 
ATOM   3148 C CE1 . HIS A 1 583 ? -9.286  47.629  84.409  1.00 75.97  ?  564 HIS A CE1 1 
ATOM   3149 N NE2 . HIS A 1 583 ? -9.940  46.951  85.339  1.00 73.92  ?  564 HIS A NE2 1 
ATOM   3150 N N   . LEU A 1 584 ? -15.464 49.621  83.512  1.00 81.90  ?  565 LEU A N   1 
ATOM   3151 C CA  . LEU A 1 584 ? -16.742 50.227  83.158  1.00 79.34  ?  565 LEU A CA  1 
ATOM   3152 C C   . LEU A 1 584 ? -16.491 51.592  82.538  1.00 80.75  ?  565 LEU A C   1 
ATOM   3153 O O   . LEU A 1 584 ? -15.423 52.180  82.706  1.00 79.14  ?  565 LEU A O   1 
ATOM   3154 C CB  . LEU A 1 584 ? -17.653 50.362  84.386  1.00 75.98  ?  565 LEU A CB  1 
ATOM   3155 C CG  . LEU A 1 584 ? -18.334 49.139  85.021  1.00 81.59  ?  565 LEU A CG  1 
ATOM   3156 C CD1 . LEU A 1 584 ? -17.354 48.105  85.524  1.00 79.74  ?  565 LEU A CD1 1 
ATOM   3157 C CD2 . LEU A 1 584 ? -19.234 49.549  86.177  1.00 85.25  ?  565 LEU A CD2 1 
ATOM   3158 N N   . THR A 1 585 ? -17.470 52.087  81.799  1.00 81.88  ?  566 THR A N   1 
ATOM   3159 C CA  . THR A 1 585 ? -17.438 53.458  81.319  1.00 83.21  ?  566 THR A CA  1 
ATOM   3160 C C   . THR A 1 585 ? -18.606 54.197  81.921  1.00 86.62  ?  566 THR A C   1 
ATOM   3161 O O   . THR A 1 585 ? -19.443 53.607  82.612  1.00 85.56  ?  566 THR A O   1 
ATOM   3162 C CB  . THR A 1 585 ? -17.495 53.565  79.787  1.00 91.03  ?  566 THR A CB  1 
ATOM   3163 O OG1 . THR A 1 585 ? -18.732 53.032  79.290  1.00 93.73  ?  566 THR A OG1 1 
ATOM   3164 C CG2 . THR A 1 585 ? -16.331 52.862  79.159  1.00 84.76  ?  566 THR A CG2 1 
ATOM   3165 N N   . VAL A 1 586 ? -18.657 55.498  81.636  1.00 85.52  ?  567 VAL A N   1 
ATOM   3166 C CA  . VAL A 1 586 ? -19.668 56.385  82.194  1.00 92.37  ?  567 VAL A CA  1 
ATOM   3167 C C   . VAL A 1 586 ? -20.426 56.950  81.006  1.00 96.42  ?  567 VAL A C   1 
ATOM   3168 O O   . VAL A 1 586 ? -19.922 57.825  80.290  1.00 97.62  ?  567 VAL A O   1 
ATOM   3169 C CB  . VAL A 1 586 ? -19.061 57.491  83.063  1.00 92.14  ?  567 VAL A CB  1 
ATOM   3170 C CG1 . VAL A 1 586 ? -20.144 58.187  83.837  1.00 96.21  ?  567 VAL A CG1 1 
ATOM   3171 C CG2 . VAL A 1 586 ? -18.032 56.910  84.024  1.00 83.93  ?  567 VAL A CG2 1 
ATOM   3172 N N   . ARG A 1 587 ? -21.635 56.436  80.777  1.00 101.82 ?  568 ARG A N   1 
ATOM   3173 C CA  . ARG A 1 587 ? -22.318 56.731  79.524  1.00 105.46 ?  568 ARG A CA  1 
ATOM   3174 C C   . ARG A 1 587 ? -22.845 58.152  79.475  1.00 104.78 ?  568 ARG A C   1 
ATOM   3175 O O   . ARG A 1 587 ? -22.962 58.706  78.380  1.00 106.16 ?  568 ARG A O   1 
ATOM   3176 C CB  . ARG A 1 587 ? -23.463 55.751  79.276  1.00 110.68 ?  568 ARG A CB  1 
ATOM   3177 C CG  . ARG A 1 587 ? -23.012 54.360  78.870  1.00 112.77 ?  568 ARG A CG  1 
ATOM   3178 C CD  . ARG A 1 587 ? -24.122 53.570  78.156  1.00 121.10 ?  568 ARG A CD  1 
ATOM   3179 N NE  . ARG A 1 587 ? -23.871 53.388  76.722  1.00 122.66 ?  568 ARG A NE  1 
ATOM   3180 C CZ  . ARG A 1 587 ? -24.793 52.980  75.852  1.00 122.66 ?  568 ARG A CZ  1 
ATOM   3181 N NH1 . ARG A 1 587 ? -26.023 52.722  76.281  1.00 127.03 ?  568 ARG A NH1 1 
ATOM   3182 N NH2 . ARG A 1 587 ? -24.493 52.840  74.559  1.00 117.79 ?  568 ARG A NH2 1 
ATOM   3183 N N   . ASN A 1 588 ? -23.163 58.751  80.621  1.00 105.43 ?  569 ASN A N   1 
ATOM   3184 C CA  . ASN A 1 588 ? -23.536 60.160  80.683  1.00 105.85 ?  569 ASN A CA  1 
ATOM   3185 C C   . ASN A 1 588 ? -22.353 61.119  80.831  1.00 100.50 ?  569 ASN A C   1 
ATOM   3186 O O   . ASN A 1 588 ? -22.574 62.337  80.862  1.00 98.65  ?  569 ASN A O   1 
ATOM   3187 C CB  . ASN A 1 588 ? -24.536 60.386  81.816  1.00 103.53 ?  569 ASN A CB  1 
ATOM   3188 C CG  . ASN A 1 588 ? -24.058 59.795  83.113  1.00 110.86 ?  569 ASN A CG  1 
ATOM   3189 O OD1 . ASN A 1 588 ? -22.997 59.166  83.152  1.00 110.63 ?  569 ASN A OD1 1 
ATOM   3190 N ND2 . ASN A 1 588 ? -24.802 60.025  84.193  1.00 116.12 ?  569 ASN A ND2 1 
ATOM   3191 N N   . GLY A 1 589 ? -21.115 60.622  80.890  1.00 95.32  ?  570 GLY A N   1 
ATOM   3192 C CA  . GLY A 1 589 ? -19.966 61.502  81.021  1.00 92.69  ?  570 GLY A CA  1 
ATOM   3193 C C   . GLY A 1 589 ? -19.503 61.638  82.460  1.00 96.67  ?  570 GLY A C   1 
ATOM   3194 O O   . GLY A 1 589 ? -20.315 61.842  83.371  1.00 99.33  ?  570 GLY A O   1 
ATOM   3195 N N   . TYR A 1 590 ? -18.195 61.536  82.687  1.00 90.77  ?  571 TYR A N   1 
ATOM   3196 C CA  . TYR A 1 590 ? -17.676 61.390  84.044  1.00 84.05  ?  571 TYR A CA  1 
ATOM   3197 C C   . TYR A 1 590 ? -17.576 62.724  84.768  1.00 85.62  ?  571 TYR A C   1 
ATOM   3198 O O   . TYR A 1 590 ? -17.358 62.737  85.978  1.00 85.36  ?  571 TYR A O   1 
ATOM   3199 C CB  . TYR A 1 590 ? -16.339 60.657  83.928  1.00 78.88  ?  571 TYR A CB  1 
ATOM   3200 C CG  . TYR A 1 590 ? -15.723 59.928  85.082  1.00 77.75  ?  571 TYR A CG  1 
ATOM   3201 C CD1 . TYR A 1 590 ? -16.456 59.539  86.184  1.00 78.71  ?  571 TYR A CD1 1 
ATOM   3202 C CD2 . TYR A 1 590 ? -14.468 59.367  84.916  1.00 76.29  ?  571 TYR A CD2 1 
ATOM   3203 C CE1 . TYR A 1 590 ? -15.873 58.772  87.193  1.00 73.51  ?  571 TYR A CE1 1 
ATOM   3204 C CE2 . TYR A 1 590 ? -13.892 58.592  85.890  1.00 71.83  ?  571 TYR A CE2 1 
ATOM   3205 C CZ  . TYR A 1 590 ? -14.589 58.297  87.028  1.00 74.30  ?  571 TYR A CZ  1 
ATOM   3206 O OH  . TYR A 1 590 ? -13.976 57.509  87.985  1.00 77.98  ?  571 TYR A OH  1 
ATOM   3207 N N   . SER A 1 591 ? -17.775 63.838  84.060  1.00 83.48  ?  572 SER A N   1 
ATOM   3208 C CA  . SER A 1 591 ? -17.907 65.133  84.703  1.00 74.30  ?  572 SER A CA  1 
ATOM   3209 C C   . SER A 1 591 ? -19.071 65.184  85.681  1.00 81.45  ?  572 SER A C   1 
ATOM   3210 O O   . SER A 1 591 ? -19.093 66.061  86.552  1.00 86.71  ?  572 SER A O   1 
ATOM   3211 C CB  . SER A 1 591 ? -18.116 66.223  83.662  1.00 75.00  ?  572 SER A CB  1 
ATOM   3212 O OG  . SER A 1 591 ? -19.489 66.324  83.347  1.00 73.30  ?  572 SER A OG  1 
ATOM   3213 N N   . CYS A 1 592 ? -20.048 64.288  85.557  1.00 80.73  ?  573 CYS A N   1 
ATOM   3214 C CA  . CYS A 1 592 ? -21.186 64.332  86.468  1.00 81.63  ?  573 CYS A CA  1 
ATOM   3215 C C   . CYS A 1 592 ? -20.776 64.105  87.924  1.00 86.43  ?  573 CYS A C   1 
ATOM   3216 O O   . CYS A 1 592 ? -21.504 64.521  88.836  1.00 87.85  ?  573 CYS A O   1 
ATOM   3217 C CB  . CYS A 1 592 ? -22.244 63.304  86.037  1.00 92.74  ?  573 CYS A CB  1 
ATOM   3218 S SG  . CYS A 1 592 ? -21.856 61.537  86.350  1.00 101.44 ?  573 CYS A SG  1 
ATOM   3219 N N   . VAL A 1 593 ? -19.628 63.471  88.159  1.00 86.66  ?  574 VAL A N   1 
ATOM   3220 C CA  . VAL A 1 593 ? -19.122 63.187  89.503  1.00 84.14  ?  574 VAL A CA  1 
ATOM   3221 C C   . VAL A 1 593 ? -18.534 64.451  90.123  1.00 81.88  ?  574 VAL A C   1 
ATOM   3222 O O   . VAL A 1 593 ? -19.007 64.877  91.186  1.00 78.41  ?  574 VAL A O   1 
ATOM   3223 C CB  . VAL A 1 593 ? -18.104 62.031  89.486  1.00 78.13  ?  574 VAL A CB  1 
ATOM   3224 C CG1 . VAL A 1 593 ? -17.212 62.054  90.728  1.00 74.52  ?  574 VAL A CG1 1 
ATOM   3225 C CG2 . VAL A 1 593 ? -18.831 60.732  89.416  1.00 77.84  ?  574 VAL A CG2 1 
ATOM   3226 N N   . PRO A 1 594 ? -17.517 65.081  89.529  1.00 76.25  ?  575 PRO A N   1 
ATOM   3227 C CA  . PRO A 1 594 ? -17.016 66.304  90.146  1.00 76.08  ?  575 PRO A CA  1 
ATOM   3228 C C   . PRO A 1 594 ? -18.083 67.375  90.239  1.00 85.32  ?  575 PRO A C   1 
ATOM   3229 O O   . PRO A 1 594 ? -18.203 68.037  91.284  1.00 85.27  ?  575 PRO A O   1 
ATOM   3230 C CB  . PRO A 1 594 ? -15.850 66.704  89.227  1.00 72.34  ?  575 PRO A CB  1 
ATOM   3231 C CG  . PRO A 1 594 ? -16.112 66.055  87.981  1.00 75.47  ?  575 PRO A CG  1 
ATOM   3232 C CD  . PRO A 1 594 ? -16.725 64.753  88.336  1.00 77.91  ?  575 PRO A CD  1 
ATOM   3233 N N   . VAL A 1 595 ? -18.888 67.546  89.188  1.00 83.51  ?  576 VAL A N   1 
ATOM   3234 C CA  . VAL A 1 595 ? -19.972 68.519  89.264  1.00 78.89  ?  576 VAL A CA  1 
ATOM   3235 C C   . VAL A 1 595 ? -20.842 68.239  90.483  1.00 79.15  ?  576 VAL A C   1 
ATOM   3236 O O   . VAL A 1 595 ? -21.305 69.159  91.164  1.00 83.45  ?  576 VAL A O   1 
ATOM   3237 C CB  . VAL A 1 595 ? -20.784 68.501  87.961  1.00 72.92  ?  576 VAL A CB  1 
ATOM   3238 C CG1 . VAL A 1 595 ? -22.060 69.269  88.128  1.00 60.77  ?  576 VAL A CG1 1 
ATOM   3239 C CG2 . VAL A 1 595 ? -19.952 69.065  86.838  1.00 67.93  ?  576 VAL A CG2 1 
ATOM   3240 N N   . ALA A 1 596 ? -21.030 66.965  90.814  1.00 78.62  ?  577 ALA A N   1 
ATOM   3241 C CA  . ALA A 1 596 ? -21.882 66.631  91.949  1.00 80.53  ?  577 ALA A CA  1 
ATOM   3242 C C   . ALA A 1 596 ? -21.188 66.897  93.281  1.00 85.93  ?  577 ALA A C   1 
ATOM   3243 O O   . ALA A 1 596 ? -21.848 67.259  94.264  1.00 87.87  ?  577 ALA A O   1 
ATOM   3244 C CB  . ALA A 1 596 ? -22.322 65.171  91.854  1.00 83.21  ?  577 ALA A CB  1 
ATOM   3245 N N   . LEU A 1 597 ? -19.868 66.706  93.343  1.00 86.09  ?  578 LEU A N   1 
ATOM   3246 C CA  . LEU A 1 597 ? -19.132 66.961  94.576  1.00 79.39  ?  578 LEU A CA  1 
ATOM   3247 C C   . LEU A 1 597 ? -19.107 68.449  94.892  1.00 83.22  ?  578 LEU A C   1 
ATOM   3248 O O   . LEU A 1 597 ? -19.183 68.850  96.064  1.00 86.19  ?  578 LEU A O   1 
ATOM   3249 C CB  . LEU A 1 597 ? -17.712 66.414  94.449  1.00 75.43  ?  578 LEU A CB  1 
ATOM   3250 C CG  . LEU A 1 597 ? -17.617 64.893  94.299  1.00 77.64  ?  578 LEU A CG  1 
ATOM   3251 C CD1 . LEU A 1 597 ? -16.177 64.416  94.317  1.00 73.62  ?  578 LEU A CD1 1 
ATOM   3252 C CD2 . LEU A 1 597 ? -18.405 64.193  95.380  1.00 74.34  ?  578 LEU A CD2 1 
ATOM   3253 N N   . ALA A 1 598 ? -19.030 69.279  93.853  1.00 78.68  ?  579 ALA A N   1 
ATOM   3254 C CA  . ALA A 1 598 ? -18.974 70.727  93.986  1.00 79.40  ?  579 ALA A CA  1 
ATOM   3255 C C   . ALA A 1 598 ? -20.247 71.339  94.569  1.00 85.67  ?  579 ALA A C   1 
ATOM   3256 O O   . ALA A 1 598 ? -20.229 72.522  94.946  1.00 83.95  ?  579 ALA A O   1 
ATOM   3257 C CB  . ALA A 1 598 ? -18.679 71.338  92.619  1.00 76.53  ?  579 ALA A CB  1 
ATOM   3258 N N   . GLU A 1 599 ? -21.341 70.580  94.653  1.00 87.55  ?  580 GLU A N   1 
ATOM   3259 C CA  . GLU A 1 599 ? -22.590 71.123  95.181  1.00 92.66  ?  580 GLU A CA  1 
ATOM   3260 C C   . GLU A 1 599 ? -22.405 71.578  96.620  1.00 91.49  ?  580 GLU A C   1 
ATOM   3261 O O   . GLU A 1 599 ? -22.153 70.765  97.515  1.00 94.97  ?  580 GLU A O   1 
ATOM   3262 C CB  . GLU A 1 599 ? -23.715 70.089  95.099  1.00 97.40  ?  580 GLU A CB  1 
ATOM   3263 C CG  . GLU A 1 599 ? -25.139 70.678  95.243  1.00 105.93 ?  580 GLU A CG  1 
ATOM   3264 C CD  . GLU A 1 599 ? -26.151 69.707  95.891  1.00 122.80 ?  580 GLU A CD  1 
ATOM   3265 O OE1 . GLU A 1 599 ? -27.381 69.952  95.760  1.00 122.10 ?  580 GLU A OE1 1 
ATOM   3266 O OE2 . GLU A 1 599 ? -25.723 68.705  96.526  1.00 120.52 ?  580 GLU A OE2 1 
ATOM   3267 N N   . GLY A 1 600 ? -22.535 72.881  96.835  1.00 93.17  ?  581 GLY A N   1 
ATOM   3268 C CA  . GLY A 1 600 ? -22.494 73.429  98.171  1.00 89.45  ?  581 GLY A CA  1 
ATOM   3269 C C   . GLY A 1 600 ? -21.145 73.928  98.619  1.00 85.88  ?  581 GLY A C   1 
ATOM   3270 O O   . GLY A 1 600 ? -20.926 74.065  99.830  1.00 92.69  ?  581 GLY A O   1 
ATOM   3271 N N   . LEU A 1 601 ? -20.236 74.213  97.695  1.00 79.33  ?  582 LEU A N   1 
ATOM   3272 C CA  . LEU A 1 601 ? -18.866 74.540  98.041  1.00 75.75  ?  582 LEU A CA  1 
ATOM   3273 C C   . LEU A 1 601 ? -18.499 75.889  97.459  1.00 71.71  ?  582 LEU A C   1 
ATOM   3274 O O   . LEU A 1 601 ? -18.983 76.278  96.393  1.00 76.83  ?  582 LEU A O   1 
ATOM   3275 C CB  . LEU A 1 601 ? -17.865 73.483  97.533  1.00 74.34  ?  582 LEU A CB  1 
ATOM   3276 C CG  . LEU A 1 601 ? -17.971 72.030  97.974  1.00 80.12  ?  582 LEU A CG  1 
ATOM   3277 C CD1 . LEU A 1 601 ? -16.616 71.391  97.841  1.00 79.90  ?  582 LEU A CD1 1 
ATOM   3278 C CD2 . LEU A 1 601 ? -18.478 71.881  99.398  1.00 80.63  ?  582 LEU A CD2 1 
ATOM   3279 N N   . ASP A 1 602 ? -17.612 76.585  98.165  1.00 77.76  ?  583 ASP A N   1 
ATOM   3280 C CA  . ASP A 1 602 ? -17.164 77.919  97.767  1.00 80.16  ?  583 ASP A CA  1 
ATOM   3281 C C   . ASP A 1 602 ? -16.035 77.752  96.758  1.00 78.16  ?  583 ASP A C   1 
ATOM   3282 O O   . ASP A 1 602 ? -14.881 77.527  97.134  1.00 80.68  ?  583 ASP A O   1 
ATOM   3283 C CB  . ASP A 1 602 ? -16.711 78.726  98.985  1.00 78.02  ?  583 ASP A CB  1 
ATOM   3284 C CG  . ASP A 1 602 ? -16.430 80.201  98.653  1.00 90.42  ?  583 ASP A CG  1 
ATOM   3285 O OD1 . ASP A 1 602 ? -16.873 80.697  97.574  1.00 86.13  ?  583 ASP A OD1 1 
ATOM   3286 O OD2 . ASP A 1 602 ? -15.760 80.871  99.477  1.00 93.39  ?  583 ASP A OD2 1 
ATOM   3287 N N   . ILE A 1 603 ? -16.347 77.872  95.472  1.00 66.68  ?  584 ILE A N   1 
ATOM   3288 C CA  . ILE A 1 603 ? -15.365 77.626  94.429  1.00 71.53  ?  584 ILE A CA  1 
ATOM   3289 C C   . ILE A 1 603 ? -15.195 78.910  93.628  1.00 74.92  ?  584 ILE A C   1 
ATOM   3290 O O   . ILE A 1 603 ? -16.166 79.434  93.071  1.00 78.45  ?  584 ILE A O   1 
ATOM   3291 C CB  . ILE A 1 603 ? -15.785 76.440  93.532  1.00 77.22  ?  584 ILE A CB  1 
ATOM   3292 C CG1 . ILE A 1 603 ? -16.010 75.180  94.369  1.00 69.97  ?  584 ILE A CG1 1 
ATOM   3293 C CG2 . ILE A 1 603 ? -14.756 76.133  92.440  1.00 67.54  ?  584 ILE A CG2 1 
ATOM   3294 C CD1 . ILE A 1 603 ? -16.929 74.204  93.707  1.00 67.06  ?  584 ILE A CD1 1 
ATOM   3295 N N   . LYS A 1 604 ? -13.968 79.415  93.568  1.00 71.88  ?  585 LYS A N   1 
ATOM   3296 C CA  . LYS A 1 604 ? -13.634 80.556  92.727  1.00 68.75  ?  585 LYS A CA  1 
ATOM   3297 C C   . LYS A 1 604 ? -13.052 80.016  91.433  1.00 71.27  ?  585 LYS A C   1 
ATOM   3298 O O   . LYS A 1 604 ? -11.941 79.479  91.435  1.00 74.70  ?  585 LYS A O   1 
ATOM   3299 C CB  . LYS A 1 604 ? -12.625 81.483  93.406  1.00 72.89  ?  585 LYS A CB  1 
ATOM   3300 C CG  . LYS A 1 604 ? -12.919 81.845  94.852  1.00 76.28  ?  585 LYS A CG  1 
ATOM   3301 C CD  . LYS A 1 604 ? -14.315 82.416  95.031  1.00 79.03  ?  585 LYS A CD  1 
ATOM   3302 C CE  . LYS A 1 604 ? -14.536 82.836  96.469  1.00 85.31  ?  585 LYS A CE  1 
ATOM   3303 N NZ  . LYS A 1 604 ? -15.947 82.600  96.880  1.00 89.03  ?  585 LYS A NZ  1 
ATOM   3304 N N   . LEU A 1 605 ? -13.783 80.165  90.329  1.00 73.17  ?  586 LEU A N   1 
ATOM   3305 C CA  . LEU A 1 605 ? -13.268 79.759  89.026  1.00 71.37  ?  586 LEU A CA  1 
ATOM   3306 C C   . LEU A 1 605 ? -12.542 80.917  88.371  1.00 68.48  ?  586 LEU A C   1 
ATOM   3307 O O   . LEU A 1 605 ? -12.748 82.079  88.710  1.00 80.45  ?  586 LEU A O   1 
ATOM   3308 C CB  . LEU A 1 605 ? -14.385 79.246  88.109  1.00 66.62  ?  586 LEU A CB  1 
ATOM   3309 C CG  . LEU A 1 605 ? -15.234 78.123  88.740  1.00 72.62  ?  586 LEU A CG  1 
ATOM   3310 C CD1 . LEU A 1 605 ? -16.590 77.928  88.088  1.00 69.52  ?  586 LEU A CD1 1 
ATOM   3311 C CD2 . LEU A 1 605 ? -14.484 76.806  88.774  1.00 68.71  ?  586 LEU A CD2 1 
ATOM   3312 N N   . ASN A 1 606 ? -11.686 80.586  87.418  1.00 70.78  ?  587 ASN A N   1 
ATOM   3313 C CA  . ASN A 1 606 ? -10.883 81.577  86.710  1.00 74.06  ?  587 ASN A CA  1 
ATOM   3314 C C   . ASN A 1 606 ? -9.999  82.326  87.690  1.00 76.10  ?  587 ASN A C   1 
ATOM   3315 O O   . ASN A 1 606 ? -9.915  83.556  87.694  1.00 81.27  ?  587 ASN A O   1 
ATOM   3316 C CB  . ASN A 1 606 ? -11.767 82.526  85.915  1.00 77.26  ?  587 ASN A CB  1 
ATOM   3317 C CG  . ASN A 1 606 ? -12.662 81.788  84.980  1.00 80.01  ?  587 ASN A CG  1 
ATOM   3318 O OD1 . ASN A 1 606 ? -12.191 81.098  84.061  1.00 85.09  ?  587 ASN A OD1 1 
ATOM   3319 N ND2 . ASN A 1 606 ? -13.959 81.862  85.235  1.00 75.24  ?  587 ASN A ND2 1 
ATOM   3320 N N   . THR A 1 607 ? -9.449  81.548  88.600  1.00 74.61  ?  588 THR A N   1 
ATOM   3321 C CA  . THR A 1 607 ? -8.595  82.053  89.688  1.00 69.54  ?  588 THR A CA  1 
ATOM   3322 C C   . THR A 1 607 ? -7.299  81.264  89.654  1.00 62.12  ?  588 THR A C   1 
ATOM   3323 O O   . THR A 1 607 ? -7.299  80.166  90.092  1.00 56.26  ?  588 THR A O   1 
ATOM   3324 C CB  . THR A 1 607 ? -9.319  81.834  91.013  1.00 72.81  ?  588 THR A CB  1 
ATOM   3325 O OG1 . THR A 1 607 ? -10.688 82.154  90.830  1.00 68.18  ?  588 THR A OG1 1 
ATOM   3326 C CG2 . THR A 1 607 ? -8.805  82.719  92.115  1.00 66.30  ?  588 THR A CG2 1 
ATOM   3327 N N   . ALA A 1 608 ? -6.234  81.834  89.133  1.00 61.20  ?  589 ALA A N   1 
ATOM   3328 C CA  . ALA A 1 608 ? -4.994  81.051  89.047  1.00 59.93  ?  589 ALA A CA  1 
ATOM   3329 C C   . ALA A 1 608 ? -4.049  81.413  90.177  1.00 62.41  ?  589 ALA A C   1 
ATOM   3330 O O   . ALA A 1 608 ? -3.656  82.530  90.255  1.00 63.36  ?  589 ALA A O   1 
ATOM   3331 C CB  . ALA A 1 608 ? -4.340  81.291  87.730  1.00 57.56  ?  589 ALA A CB  1 
ATOM   3332 N N   . VAL A 1 609 ? -3.669  80.441  90.980  1.00 58.63  ?  590 VAL A N   1 
ATOM   3333 C CA  . VAL A 1 609 ? -2.737  80.706  92.092  1.00 57.71  ?  590 VAL A CA  1 
ATOM   3334 C C   . VAL A 1 609 ? -1.386  80.994  91.475  1.00 61.03  ?  590 VAL A C   1 
ATOM   3335 O O   . VAL A 1 609 ? -1.045  80.347  90.540  1.00 57.79  ?  590 VAL A O   1 
ATOM   3336 C CB  . VAL A 1 609 ? -2.712  79.516  93.048  1.00 59.73  ?  590 VAL A CB  1 
ATOM   3337 C CG1 . VAL A 1 609 ? -1.457  79.470  93.881  1.00 54.75  ?  590 VAL A CG1 1 
ATOM   3338 C CG2 . VAL A 1 609 ? -3.923  79.552  93.938  1.00 57.73  ?  590 VAL A CG2 1 
ATOM   3339 N N   . ARG A 1 610 ? -0.678  81.977  91.995  1.00 65.16  ?  591 ARG A N   1 
ATOM   3340 C CA  . ARG A 1 610 ? 0.621   82.337  91.413  1.00 64.14  ?  591 ARG A CA  1 
ATOM   3341 C C   . ARG A 1 610 ? 1.668   82.204  92.508  1.00 64.65  ?  591 ARG A C   1 
ATOM   3342 O O   . ARG A 1 610 ? 2.806   81.988  92.192  1.00 62.43  ?  591 ARG A O   1 
ATOM   3343 C CB  . ARG A 1 610 ? 0.514   83.773  90.908  1.00 65.26  ?  591 ARG A CB  1 
ATOM   3344 C CG  . ARG A 1 610 ? 1.052   84.015  89.511  1.00 76.10  ?  591 ARG A CG  1 
ATOM   3345 C CD  . ARG A 1 610 ? -0.064  84.057  88.508  1.00 89.00  ?  591 ARG A CD  1 
ATOM   3346 N NE  . ARG A 1 610 ? 0.013   84.996  87.401  1.00 100.48 ?  591 ARG A NE  1 
ATOM   3347 C CZ  . ARG A 1 610 ? 1.072   85.695  87.016  1.00 105.27 ?  591 ARG A CZ  1 
ATOM   3348 N NH1 . ARG A 1 610 ? 2.232   85.606  87.641  1.00 112.77 ?  591 ARG A NH1 1 
ATOM   3349 N NH2 . ARG A 1 610 ? 0.970   86.494  85.977  1.00 99.79  ?  591 ARG A NH2 1 
ATOM   3350 N N   . GLN A 1 611 ? 1.259   82.289  93.762  1.00 58.84  ?  592 GLN A N   1 
ATOM   3351 C CA  . GLN A 1 611 ? 2.256   82.216  94.842  1.00 57.83  ?  592 GLN A CA  1 
ATOM   3352 C C   . GLN A 1 611 ? 1.628   81.653  96.100  1.00 60.85  ?  592 GLN A C   1 
ATOM   3353 O O   . GLN A 1 611 ? 0.517   81.996  96.387  1.00 61.76  ?  592 GLN A O   1 
ATOM   3354 C CB  . GLN A 1 611 ? 2.672   83.636  95.159  1.00 67.19  ?  592 GLN A CB  1 
ATOM   3355 C CG  . GLN A 1 611 ? 3.754   83.730  96.208  1.00 70.80  ?  592 GLN A CG  1 
ATOM   3356 C CD  . GLN A 1 611 ? 4.629   84.922  95.964  1.00 67.09  ?  592 GLN A CD  1 
ATOM   3357 O OE1 . GLN A 1 611 ? 4.749   85.787  96.796  1.00 70.87  ?  592 GLN A OE1 1 
ATOM   3358 N NE2 . GLN A 1 611 ? 5.257   84.964  94.817  1.00 58.04  ?  592 GLN A NE2 1 
ATOM   3359 N N   . VAL A 1 612 ? 2.346   80.793  96.803  1.00 56.29  ?  593 VAL A N   1 
ATOM   3360 C CA  . VAL A 1 612 ? 1.808   80.250  98.075  1.00 60.06  ?  593 VAL A CA  1 
ATOM   3361 C C   . VAL A 1 612 ? 2.756   80.665  99.180  1.00 61.22  ?  593 VAL A C   1 
ATOM   3362 O O   . VAL A 1 612 ? 3.909   80.370  99.081  1.00 61.57  ?  593 VAL A O   1 
ATOM   3363 C CB  . VAL A 1 612 ? 1.624   78.733  98.046  1.00 60.17  ?  593 VAL A CB  1 
ATOM   3364 C CG1 . VAL A 1 612 ? 1.020   78.248  99.333  1.00 50.13  ?  593 VAL A CG1 1 
ATOM   3365 C CG2 . VAL A 1 612 ? 0.734   78.326  96.912  1.00 60.89  ?  593 VAL A CG2 1 
ATOM   3366 N N   . ARG A 1 613 ? 2.233   81.340  100.187 1.00 57.27  ?  594 ARG A N   1 
ATOM   3367 C CA  . ARG A 1 613 ? 3.068   81.841  101.286 1.00 56.80  ?  594 ARG A CA  1 
ATOM   3368 C C   . ARG A 1 613 ? 2.648   81.144  102.562 1.00 65.13  ?  594 ARG A C   1 
ATOM   3369 O O   . ARG A 1 613 ? 1.493   81.237  102.916 1.00 65.58  ?  594 ARG A O   1 
ATOM   3370 C CB  . ARG A 1 613 ? 2.811   83.334  101.428 1.00 68.15  ?  594 ARG A CB  1 
ATOM   3371 C CG  . ARG A 1 613 ? 3.721   84.195  100.572 1.00 75.19  ?  594 ARG A CG  1 
ATOM   3372 C CD  . ARG A 1 613 ? 3.636   85.668  100.852 1.00 66.12  ?  594 ARG A CD  1 
ATOM   3373 N NE  . ARG A 1 613 ? 4.702   86.235  100.075 1.00 72.16  ?  594 ARG A NE  1 
ATOM   3374 C CZ  . ARG A 1 613 ? 5.849   86.586  100.591 1.00 77.02  ?  594 ARG A CZ  1 
ATOM   3375 N NH1 . ARG A 1 613 ? 6.043   86.447  101.881 1.00 66.85  ?  594 ARG A NH1 1 
ATOM   3376 N NH2 . ARG A 1 613 ? 6.792   87.095  99.830  1.00 78.52  ?  594 ARG A NH2 1 
ATOM   3377 N N   . TYR A 1 614 ? 3.595   80.502  103.226 1.00 63.29  ?  595 TYR A N   1 
ATOM   3378 C CA  . TYR A 1 614 ? 3.281   79.770  104.450 1.00 68.60  ?  595 TYR A CA  1 
ATOM   3379 C C   . TYR A 1 614 ? 4.329   80.104  105.510 1.00 67.15  ?  595 TYR A C   1 
ATOM   3380 O O   . TYR A 1 614 ? 5.537   80.072  105.239 1.00 67.54  ?  595 TYR A O   1 
ATOM   3381 C CB  . TYR A 1 614 ? 3.172   78.231  104.193 1.00 62.87  ?  595 TYR A CB  1 
ATOM   3382 C CG  . TYR A 1 614 ? 4.422   77.612  103.604 1.00 59.31  ?  595 TYR A CG  1 
ATOM   3383 C CD1 . TYR A 1 614 ? 4.705   77.726  102.246 1.00 57.98  ?  595 TYR A CD1 1 
ATOM   3384 C CD2 . TYR A 1 614 ? 5.336   76.945  104.414 1.00 56.08  ?  595 TYR A CD2 1 
ATOM   3385 C CE1 . TYR A 1 614 ? 5.856   77.195  101.711 1.00 57.21  ?  595 TYR A CE1 1 
ATOM   3386 C CE2 . TYR A 1 614 ? 6.495   76.411  103.890 1.00 57.65  ?  595 TYR A CE2 1 
ATOM   3387 C CZ  . TYR A 1 614 ? 6.748   76.539  102.540 1.00 59.75  ?  595 TYR A CZ  1 
ATOM   3388 O OH  . TYR A 1 614 ? 7.899   76.010  102.015 1.00 63.55  ?  595 TYR A OH  1 
ATOM   3389 N N   . THR A 1 615 ? 3.858   80.454  106.704 1.00 64.55  ?  596 THR A N   1 
ATOM   3390 C CA  . THR A 1 615 ? 4.714   80.852  107.819 1.00 70.76  ?  596 THR A CA  1 
ATOM   3391 C C   . THR A 1 615 ? 4.155   80.248  109.093 1.00 70.70  ?  596 THR A C   1 
ATOM   3392 O O   . THR A 1 615 ? 3.104   79.597  109.087 1.00 70.02  ?  596 THR A O   1 
ATOM   3393 C CB  . THR A 1 615 ? 4.782   82.371  108.000 1.00 72.99  ?  596 THR A CB  1 
ATOM   3394 O OG1 . THR A 1 615 ? 3.467   82.864  108.316 1.00 74.19  ?  596 THR A OG1 1 
ATOM   3395 C CG2 . THR A 1 615 ? 5.357   83.065  106.752 1.00 61.56  ?  596 THR A CG2 1 
ATOM   3396 N N   . ALA A 1 616 ? 4.841   80.507  110.206 1.00 69.75  ?  597 ALA A N   1 
ATOM   3397 C CA  . ALA A 1 616 ? 4.435   79.871  111.452 1.00 64.51  ?  597 ALA A CA  1 
ATOM   3398 C C   . ALA A 1 616 ? 3.056   80.316  111.920 1.00 64.81  ?  597 ALA A C   1 
ATOM   3399 O O   . ALA A 1 616 ? 2.395   79.565  112.629 1.00 61.61  ?  597 ALA A O   1 
ATOM   3400 C CB  . ALA A 1 616 ? 5.473   80.126  112.532 1.00 63.78  ?  597 ALA A CB  1 
ATOM   3401 N N   . SER A 1 617 ? 2.575   81.490  111.512 1.00 73.53  ?  598 SER A N   1 
ATOM   3402 C CA  . SER A 1 617 ? 1.307   81.988  112.036 1.00 72.43  ?  598 SER A CA  1 
ATOM   3403 C C   . SER A 1 617 ? 0.115   81.683  111.136 1.00 74.93  ?  598 SER A C   1 
ATOM   3404 O O   . SER A 1 617 ? -1.033  81.819  111.586 1.00 75.22  ?  598 SER A O   1 
ATOM   3405 C CB  . SER A 1 617 ? 1.414   83.491  112.287 1.00 72.63  ?  598 SER A CB  1 
ATOM   3406 O OG  . SER A 1 617 ? 1.954   84.146  111.151 1.00 82.90  ?  598 SER A OG  1 
ATOM   3407 N N   . GLY A 1 618 ? 0.362   81.244  109.909 1.00 68.36  ?  599 GLY A N   1 
ATOM   3408 C CA  . GLY A 1 618 ? -0.689  81.010  108.941 1.00 67.96  ?  599 GLY A CA  1 
ATOM   3409 C C   . GLY A 1 618 ? -0.158  81.220  107.530 1.00 72.49  ?  599 GLY A C   1 
ATOM   3410 O O   . GLY A 1 618 ? 1.050   81.297  107.296 1.00 72.81  ?  599 GLY A O   1 
ATOM   3411 N N   . CYS A 1 619 ? -1.093  81.342  106.583 1.00 68.70  ?  600 CYS A N   1 
ATOM   3412 C CA  . CYS A 1 619 ? -0.763  81.222  105.169 1.00 70.21  ?  600 CYS A CA  1 
ATOM   3413 C C   . CYS A 1 619 ? -1.495  82.283  104.384 1.00 67.72  ?  600 CYS A C   1 
ATOM   3414 O O   . CYS A 1 619 ? -2.636  82.630  104.709 1.00 70.47  ?  600 CYS A O   1 
ATOM   3415 C CB  . CYS A 1 619 ? -1.212  79.871  104.594 1.00 72.71  ?  600 CYS A CB  1 
ATOM   3416 S SG  . CYS A 1 619 ? -0.373  78.458  105.269 1.00 76.37  ?  600 CYS A SG  1 
ATOM   3417 N N   . GLU A 1 620 ? -0.872  82.745  103.310 1.00 68.98  ?  601 GLU A N   1 
ATOM   3418 C CA  . GLU A 1 620 ? -1.602  83.548  102.334 1.00 78.49  ?  601 GLU A CA  1 
ATOM   3419 C C   . GLU A 1 620 ? -1.311  83.043  100.923 1.00 72.61  ?  601 GLU A C   1 
ATOM   3420 O O   . GLU A 1 620 ? -0.152  82.800  100.559 1.00 67.69  ?  601 GLU A O   1 
ATOM   3421 C CB  . GLU A 1 620 ? -1.330  85.076  102.507 1.00 83.40  ?  601 GLU A CB  1 
ATOM   3422 C CG  . GLU A 1 620 ? 0.069   85.658  102.168 1.00 87.59  ?  601 GLU A CG  1 
ATOM   3423 C CD  . GLU A 1 620 ? 0.419   86.949  102.977 1.00 98.07  ?  601 GLU A CD  1 
ATOM   3424 O OE1 . GLU A 1 620 ? -0.132  87.171  104.083 1.00 102.64 ?  601 GLU A OE1 1 
ATOM   3425 O OE2 . GLU A 1 620 ? 1.268   87.741  102.518 1.00 103.31 ?  601 GLU A OE2 1 
ATOM   3426 N N   . VAL A 1 621 ? -2.387  82.834  100.164 1.00 67.83  ?  602 VAL A N   1 
ATOM   3427 C CA  . VAL A 1 621 ? -2.339  82.400  98.772  1.00 69.98  ?  602 VAL A CA  1 
ATOM   3428 C C   . VAL A 1 621 ? -2.657  83.596  97.889  1.00 69.42  ?  602 VAL A C   1 
ATOM   3429 O O   . VAL A 1 621 ? -3.647  84.299  98.133  1.00 74.74  ?  602 VAL A O   1 
ATOM   3430 C CB  . VAL A 1 621 ? -3.351  81.272  98.503  1.00 70.25  ?  602 VAL A CB  1 
ATOM   3431 C CG1 . VAL A 1 621 ? -3.152  80.723  97.108  1.00 71.10  ?  602 VAL A CG1 1 
ATOM   3432 C CG2 . VAL A 1 621 ? -3.254  80.175  99.548  1.00 64.67  ?  602 VAL A CG2 1 
ATOM   3433 N N   . ILE A 1 622 ? -1.860  83.801  96.845  1.00 65.34  ?  603 ILE A N   1 
ATOM   3434 C CA  . ILE A 1 622 ? -2.031  84.919  95.914  1.00 69.51  ?  603 ILE A CA  1 
ATOM   3435 C C   . ILE A 1 622 ? -2.457  84.398  94.548  1.00 72.98  ?  603 ILE A C   1 
ATOM   3436 O O   . ILE A 1 622 ? -1.700  83.661  93.898  1.00 72.57  ?  603 ILE A O   1 
ATOM   3437 C CB  . ILE A 1 622 ? -0.740  85.725  95.768  1.00 72.06  ?  603 ILE A CB  1 
ATOM   3438 C CG1 . ILE A 1 622 ? -0.175  86.059  97.148  1.00 77.48  ?  603 ILE A CG1 1 
ATOM   3439 C CG2 . ILE A 1 622 ? -0.994  86.959  94.938  1.00 67.74  ?  603 ILE A CG2 1 
ATOM   3440 C CD1 . ILE A 1 622 ? 1.135   86.806  97.073  1.00 78.47  ?  603 ILE A CD1 1 
ATOM   3441 N N   . ALA A 1 623 ? -3.630  84.828  94.076  1.00 70.88  ?  604 ALA A N   1 
ATOM   3442 C CA  . ALA A 1 623 ? -4.154  84.380  92.791  1.00 68.76  ?  604 ALA A CA  1 
ATOM   3443 C C   . ALA A 1 623 ? -4.571  85.556  91.904  1.00 77.36  ?  604 ALA A C   1 
ATOM   3444 O O   . ALA A 1 623 ? -5.030  86.599  92.390  1.00 79.17  ?  604 ALA A O   1 
ATOM   3445 C CB  . ALA A 1 623 ? -5.345  83.439  92.998  1.00 68.85  ?  604 ALA A CB  1 
ATOM   3446 N N   . VAL A 1 624 ? -4.425  85.372  90.592  1.00 75.81  ?  605 VAL A N   1 
ATOM   3447 C CA  . VAL A 1 624 ? -4.871  86.350  89.611  1.00 74.15  ?  605 VAL A CA  1 
ATOM   3448 C C   . VAL A 1 624 ? -6.139  85.824  88.944  1.00 77.20  ?  605 VAL A C   1 
ATOM   3449 O O   . VAL A 1 624 ? -6.543  84.681  89.136  1.00 79.48  ?  605 VAL A O   1 
ATOM   3450 C CB  . VAL A 1 624 ? -3.806  86.633  88.544  1.00 76.20  ?  605 VAL A CB  1 
ATOM   3451 C CG1 . VAL A 1 624 ? -2.506  87.042  89.182  1.00 75.10  ?  605 VAL A CG1 1 
ATOM   3452 C CG2 . VAL A 1 624 ? -3.663  85.455  87.611  1.00 76.89  ?  605 VAL A CG2 1 
ATOM   3453 N N   . ASN A 1 625 ? -6.760  86.677  88.139  1.00 82.13  ?  606 ASN A N   1 
ATOM   3454 C CA  . ASN A 1 625 ? -7.895  86.287  87.318  1.00 84.83  ?  606 ASN A CA  1 
ATOM   3455 C C   . ASN A 1 625 ? -7.399  85.869  85.933  1.00 85.38  ?  606 ASN A C   1 
ATOM   3456 O O   . ASN A 1 625 ? -6.590  86.573  85.316  1.00 83.18  ?  606 ASN A O   1 
ATOM   3457 C CB  . ASN A 1 625 ? -8.887  87.444  87.221  1.00 90.70  ?  606 ASN A CB  1 
ATOM   3458 C CG  . ASN A 1 625 ? -10.221 87.016  86.672  1.00 90.50  ?  606 ASN A CG  1 
ATOM   3459 O OD1 . ASN A 1 625 ? -11.090 86.525  87.403  1.00 95.43  ?  606 ASN A OD1 1 
ATOM   3460 N ND2 . ASN A 1 625 ? -10.389 87.175  85.375  1.00 90.79  ?  606 ASN A ND2 1 
ATOM   3461 N N   . THR A 1 626 ? -7.869  84.715  85.448  1.00 85.02  ?  607 THR A N   1 
ATOM   3462 C CA  . THR A 1 626 ? -7.269  84.156  84.231  1.00 89.33  ?  607 THR A CA  1 
ATOM   3463 C C   . THR A 1 626 ? -7.607  84.980  82.992  1.00 91.86  ?  607 THR A C   1 
ATOM   3464 O O   . THR A 1 626 ? -6.825  85.012  82.037  1.00 93.23  ?  607 THR A O   1 
ATOM   3465 C CB  . THR A 1 626 ? -7.697  82.702  84.024  1.00 81.99  ?  607 THR A CB  1 
ATOM   3466 O OG1 . THR A 1 626 ? -9.099  82.560  84.281  1.00 85.15  ?  607 THR A OG1 1 
ATOM   3467 C CG2 . THR A 1 626 ? -6.950  81.805  84.959  1.00 78.73  ?  607 THR A CG2 1 
ATOM   3468 N N   . ARG A 1 627 ? -8.747  85.660  82.995  1.00 93.10  ?  608 ARG A N   1 
ATOM   3469 C CA  . ARG A 1 627 ? -9.190  86.470  81.869  1.00 94.41  ?  608 ARG A CA  1 
ATOM   3470 C C   . ARG A 1 627 ? -8.369  87.763  81.728  1.00 99.37  ?  608 ARG A C   1 
ATOM   3471 O O   . ARG A 1 627 ? -7.584  87.919  80.776  1.00 95.29  ?  608 ARG A O   1 
ATOM   3472 C CB  . ARG A 1 627 ? -10.692 86.721  82.046  1.00 89.81  ?  608 ARG A CB  1 
ATOM   3473 C CG  . ARG A 1 627 ? -11.466 85.408  82.315  1.00 85.25  ?  608 ARG A CG  1 
ATOM   3474 C CD  . ARG A 1 627 ? -12.871 85.637  82.851  1.00 82.35  ?  608 ARG A CD  1 
ATOM   3475 N NE  . ARG A 1 627 ? -12.877 85.860  84.298  1.00 92.23  ?  608 ARG A NE  1 
ATOM   3476 C CZ  . ARG A 1 627 ? -13.791 85.370  85.141  1.00 97.13  ?  608 ARG A CZ  1 
ATOM   3477 N NH1 . ARG A 1 627 ? -14.796 84.638  84.667  1.00 100.77 ?  608 ARG A NH1 1 
ATOM   3478 N NH2 . ARG A 1 627 ? -13.720 85.629  86.456  1.00 91.93  ?  608 ARG A NH2 1 
ATOM   3479 N N   . SER A 1 628 ? -8.529  88.694  82.670  1.00 95.90  ?  609 SER A N   1 
ATOM   3480 C CA  . SER A 1 628 ? -7.601  89.820  82.828  1.00 102.64 ?  609 SER A CA  1 
ATOM   3481 C C   . SER A 1 628 ? -6.664  89.457  83.977  1.00 100.24 ?  609 SER A C   1 
ATOM   3482 O O   . SER A 1 628 ? -7.089  89.427  85.139  1.00 97.00  ?  609 SER A O   1 
ATOM   3483 C CB  . SER A 1 628 ? -8.349  91.124  83.116  1.00 105.33 ?  609 SER A CB  1 
ATOM   3484 O OG  . SER A 1 628 ? -8.806  91.180  84.466  1.00 97.10  ?  609 SER A OG  1 
ATOM   3485 N N   . THR A 1 629 ? -5.382  89.187  83.664  1.00 99.41  ?  610 THR A N   1 
ATOM   3486 C CA  . THR A 1 629 ? -4.436  88.787  84.710  1.00 94.74  ?  610 THR A CA  1 
ATOM   3487 C C   . THR A 1 629 ? -4.198  89.984  85.612  1.00 99.53  ?  610 THR A C   1 
ATOM   3488 O O   . THR A 1 629 ? -3.410  89.919  86.565  1.00 95.98  ?  610 THR A O   1 
ATOM   3489 C CB  . THR A 1 629 ? -3.073  88.308  84.175  1.00 93.42  ?  610 THR A CB  1 
ATOM   3490 O OG1 . THR A 1 629 ? -2.370  89.397  83.561  1.00 99.90  ?  610 THR A OG1 1 
ATOM   3491 C CG2 . THR A 1 629 ? -3.242  87.137  83.201  1.00 86.32  ?  610 THR A CG2 1 
ATOM   3492 N N   . SER A 1 630 ? -4.869  91.090  85.282  1.00 105.76 ?  611 SER A N   1 
ATOM   3493 C CA  . SER A 1 630 ? -4.787  92.308  86.075  1.00 100.19 ?  611 SER A CA  1 
ATOM   3494 C C   . SER A 1 630 ? -5.298  92.085  87.506  1.00 93.18  ?  611 SER A C   1 
ATOM   3495 O O   . SER A 1 630 ? -4.558  92.259  88.480  1.00 86.31  ?  611 SER A O   1 
ATOM   3496 C CB  . SER A 1 630 ? -5.519  93.450  85.352  1.00 105.77 ?  611 SER A CB  1 
ATOM   3497 O OG  . SER A 1 630 ? -6.876  93.140  85.040  1.00 115.34 ?  611 SER A OG  1 
ATOM   3498 N N   . GLN A 1 631 ? -6.532  91.638  87.656  1.00 90.57  ?  612 GLN A N   1 
ATOM   3499 C CA  . GLN A 1 631 ? -7.176  91.676  88.958  1.00 85.69  ?  612 GLN A CA  1 
ATOM   3500 C C   . GLN A 1 631 ? -6.532  90.656  89.913  1.00 88.15  ?  612 GLN A C   1 
ATOM   3501 O O   . GLN A 1 631 ? -6.608  89.444  89.680  1.00 86.99  ?  612 GLN A O   1 
ATOM   3502 C CB  . GLN A 1 631 ? -8.660  91.429  88.731  1.00 87.64  ?  612 GLN A CB  1 
ATOM   3503 C CG  . GLN A 1 631 ? -9.491  91.376  89.957  1.00 97.32  ?  612 GLN A CG  1 
ATOM   3504 C CD  . GLN A 1 631 ? -10.889 91.825  89.655  1.00 106.82 ?  612 GLN A CD  1 
ATOM   3505 O OE1 . GLN A 1 631 ? -11.458 91.416  88.633  1.00 106.02 ?  612 GLN A OE1 1 
ATOM   3506 N NE2 . GLN A 1 631 ? -11.471 92.652  90.543  1.00 102.24 ?  612 GLN A NE2 1 
ATOM   3507 N N   . THR A 1 632 ? -5.903  91.139  91.003  1.00 87.60  ?  613 THR A N   1 
ATOM   3508 C CA  . THR A 1 632 ? -5.100  90.316  91.920  1.00 76.08  ?  613 THR A CA  1 
ATOM   3509 C C   . THR A 1 632 ? -5.835  90.033  93.229  1.00 71.25  ?  613 THR A C   1 
ATOM   3510 O O   . THR A 1 632 ? -6.530  90.903  93.756  1.00 77.99  ?  613 THR A O   1 
ATOM   3511 C CB  . THR A 1 632 ? -3.766  91.001  92.234  1.00 64.94  ?  613 THR A CB  1 
ATOM   3512 O OG1 . THR A 1 632 ? -2.892  90.916  91.103  1.00 74.57  ?  613 THR A OG1 1 
ATOM   3513 C CG2 . THR A 1 632 ? -3.105  90.351  93.368  1.00 64.86  ?  613 THR A CG2 1 
ATOM   3514 N N   . PHE A 1 633 ? -5.675  88.812  93.761  1.00 73.42  ?  614 PHE A N   1 
ATOM   3515 C CA  . PHE A 1 633 ? -6.389  88.390  94.967  1.00 76.55  ?  614 PHE A CA  1 
ATOM   3516 C C   . PHE A 1 633 ? -5.464  87.822  96.049  1.00 76.28  ?  614 PHE A C   1 
ATOM   3517 O O   . PHE A 1 633 ? -4.397  87.262  95.774  1.00 77.37  ?  614 PHE A O   1 
ATOM   3518 C CB  . PHE A 1 633 ? -7.434  87.340  94.663  1.00 70.98  ?  614 PHE A CB  1 
ATOM   3519 C CG  . PHE A 1 633 ? -8.559  87.829  93.820  1.00 79.53  ?  614 PHE A CG  1 
ATOM   3520 C CD1 . PHE A 1 633 ? -9.829  88.013  94.366  1.00 75.09  ?  614 PHE A CD1 1 
ATOM   3521 C CD2 . PHE A 1 633 ? -8.361  88.076  92.458  1.00 84.94  ?  614 PHE A CD2 1 
ATOM   3522 C CE1 . PHE A 1 633 ? -10.886 88.446  93.563  1.00 84.51  ?  614 PHE A CE1 1 
ATOM   3523 C CE2 . PHE A 1 633 ? -9.399  88.518  91.650  1.00 85.04  ?  614 PHE A CE2 1 
ATOM   3524 C CZ  . PHE A 1 633 ? -10.666 88.703  92.199  1.00 87.21  ?  614 PHE A CZ  1 
ATOM   3525 N N   . ILE A 1 634 ? -5.922  87.928  97.289  1.00 68.19  ?  615 ILE A N   1 
ATOM   3526 C CA  . ILE A 1 634 ? -5.149  87.537  98.453  1.00 72.70  ?  615 ILE A CA  1 
ATOM   3527 C C   . ILE A 1 634 ? -6.067  86.750  99.375  1.00 76.44  ?  615 ILE A C   1 
ATOM   3528 O O   . ILE A 1 634 ? -7.165  87.217  99.712  1.00 75.69  ?  615 ILE A O   1 
ATOM   3529 C CB  . ILE A 1 634 ? -4.575  88.761  99.186  1.00 73.79  ?  615 ILE A CB  1 
ATOM   3530 C CG1 . ILE A 1 634 ? -3.486  89.436  98.367  1.00 69.85  ?  615 ILE A CG1 1 
ATOM   3531 C CG2 . ILE A 1 634 ? -3.979  88.327  100.509 1.00 77.99  ?  615 ILE A CG2 1 
ATOM   3532 C CD1 . ILE A 1 634 ? -2.197  88.714  98.379  1.00 74.57  ?  615 ILE A CD1 1 
ATOM   3533 N N   . TYR A 1 635 ? -5.624  85.559  99.783  1.00 72.90  ?  616 TYR A N   1 
ATOM   3534 C CA  . TYR A 1 635 ? -6.449  84.652  100.570 1.00 72.85  ?  616 TYR A CA  1 
ATOM   3535 C C   . TYR A 1 635 ? -5.668  84.214  101.799 1.00 74.90  ?  616 TYR A C   1 
ATOM   3536 O O   . TYR A 1 635 ? -4.614  83.580  101.671 1.00 75.33  ?  616 TYR A O   1 
ATOM   3537 C CB  . TYR A 1 635 ? -6.876  83.445  99.735  1.00 72.11  ?  616 TYR A CB  1 
ATOM   3538 C CG  . TYR A 1 635 ? -7.908  83.743  98.663  1.00 70.70  ?  616 TYR A CG  1 
ATOM   3539 C CD1 . TYR A 1 635 ? -7.523  84.003  97.350  1.00 66.90  ?  616 TYR A CD1 1 
ATOM   3540 C CD2 . TYR A 1 635 ? -9.278  83.737  98.962  1.00 69.86  ?  616 TYR A CD2 1 
ATOM   3541 C CE1 . TYR A 1 635 ? -8.463  84.270  96.364  1.00 65.52  ?  616 TYR A CE1 1 
ATOM   3542 C CE2 . TYR A 1 635 ? -10.235 84.001  97.978  1.00 61.15  ?  616 TYR A CE2 1 
ATOM   3543 C CZ  . TYR A 1 635 ? -9.819  84.273  96.686  1.00 68.16  ?  616 TYR A CZ  1 
ATOM   3544 O OH  . TYR A 1 635 ? -10.761 84.544  95.702  1.00 77.84  ?  616 TYR A OH  1 
ATOM   3545 N N   . LYS A 1 636 ? -6.170  84.564  102.982 1.00 72.68  ?  617 LYS A N   1 
ATOM   3546 C CA  . LYS A 1 636 ? -5.477  84.284  104.231 1.00 71.31  ?  617 LYS A CA  1 
ATOM   3547 C C   . LYS A 1 636 ? -6.137  83.089  104.895 1.00 70.45  ?  617 LYS A C   1 
ATOM   3548 O O   . LYS A 1 636 ? -7.367  83.002  104.945 1.00 79.69  ?  617 LYS A O   1 
ATOM   3549 C CB  . LYS A 1 636 ? -5.498  85.498  105.170 1.00 78.98  ?  617 LYS A CB  1 
ATOM   3550 C CG  . LYS A 1 636 ? -4.987  86.787  104.548 1.00 81.57  ?  617 LYS A CG  1 
ATOM   3551 C CD  . LYS A 1 636 ? -3.512  87.055  104.876 1.00 91.14  ?  617 LYS A CD  1 
ATOM   3552 C CE  . LYS A 1 636 ? -2.941  88.297  104.099 1.00 94.07  ?  617 LYS A CE  1 
ATOM   3553 N NZ  . LYS A 1 636 ? -3.259  89.645  104.632 1.00 78.98  ?  617 LYS A NZ  1 
ATOM   3554 N N   . CYS A 1 637 ? -5.324  82.167  105.396 1.00 58.14  ?  618 CYS A N   1 
ATOM   3555 C CA  . CYS A 1 637 ? -5.874  80.896  105.845 1.00 65.18  ?  618 CYS A CA  1 
ATOM   3556 C C   . CYS A 1 637 ? -4.902  80.231  106.802 1.00 66.82  ?  618 CYS A C   1 
ATOM   3557 O O   . CYS A 1 637 ? -3.719  80.591  106.869 1.00 62.45  ?  618 CYS A O   1 
ATOM   3558 C CB  . CYS A 1 637 ? -6.169  79.984  104.657 1.00 72.64  ?  618 CYS A CB  1 
ATOM   3559 S SG  . CYS A 1 637 ? -4.648  79.558  103.684 1.00 74.86  ?  618 CYS A SG  1 
ATOM   3560 N N   . ASP A 1 638 ? -5.429  79.260  107.554 1.00 64.72  ?  619 ASP A N   1 
ATOM   3561 C CA  . ASP A 1 638 ? -4.607  78.501  108.492 1.00 71.72  ?  619 ASP A CA  1 
ATOM   3562 C C   . ASP A 1 638 ? -3.817  77.383  107.816 1.00 70.38  ?  619 ASP A C   1 
ATOM   3563 O O   . ASP A 1 638 ? -2.816  76.921  108.376 1.00 65.59  ?  619 ASP A O   1 
ATOM   3564 C CB  . ASP A 1 638 ? -5.477  77.915  109.605 1.00 70.30  ?  619 ASP A CB  1 
ATOM   3565 C CG  . ASP A 1 638 ? -6.181  78.991  110.419 1.00 77.68  ?  619 ASP A CG  1 
ATOM   3566 O OD1 . ASP A 1 638 ? -5.469  79.834  111.020 1.00 81.54  ?  619 ASP A OD1 1 
ATOM   3567 O OD2 . ASP A 1 638 ? -7.436  78.988  110.452 1.00 72.21  ?  619 ASP A OD2 1 
ATOM   3568 N N   . ALA A 1 639 ? -4.229  76.961  106.618 1.00 78.42  ?  620 ALA A N   1 
ATOM   3569 C CA  . ALA A 1 639 ? -3.624  75.832  105.917 1.00 72.21  ?  620 ALA A CA  1 
ATOM   3570 C C   . ALA A 1 639 ? -3.981  75.924  104.444 1.00 65.58  ?  620 ALA A C   1 
ATOM   3571 O O   . ALA A 1 639 ? -5.102  76.322  104.094 1.00 65.47  ?  620 ALA A O   1 
ATOM   3572 C CB  . ALA A 1 639 ? -4.097  74.485  106.482 1.00 55.11  ?  620 ALA A CB  1 
ATOM   3573 N N   . VAL A 1 640 ? -3.020  75.558  103.596 1.00 60.33  ?  621 VAL A N   1 
ATOM   3574 C CA  . VAL A 1 640 ? -3.233  75.369  102.161 1.00 65.80  ?  621 VAL A CA  1 
ATOM   3575 C C   . VAL A 1 640 ? -3.178  73.872  101.830 1.00 65.75  ?  621 VAL A C   1 
ATOM   3576 O O   . VAL A 1 640 ? -2.256  73.159  102.261 1.00 60.93  ?  621 VAL A O   1 
ATOM   3577 C CB  . VAL A 1 640 ? -2.183  76.128  101.334 1.00 64.83  ?  621 VAL A CB  1 
ATOM   3578 C CG1 . VAL A 1 640 ? -2.601  76.195  99.871  1.00 61.03  ?  621 VAL A CG1 1 
ATOM   3579 C CG2 . VAL A 1 640 ? -1.922  77.503  101.916 1.00 64.72  ?  621 VAL A CG2 1 
ATOM   3580 N N   . LEU A 1 641 ? -4.143  73.403  101.045 1.00 61.53  ?  622 LEU A N   1 
ATOM   3581 C CA  . LEU A 1 641 ? -4.110  72.056  100.483 1.00 59.41  ?  622 LEU A CA  1 
ATOM   3582 C C   . LEU A 1 641 ? -3.831  72.185  98.997  1.00 58.90  ?  622 LEU A C   1 
ATOM   3583 O O   . LEU A 1 641 ? -4.725  72.542  98.217  1.00 59.58  ?  622 LEU A O   1 
ATOM   3584 C CB  . LEU A 1 641 ? -5.410  71.305  100.722 1.00 59.84  ?  622 LEU A CB  1 
ATOM   3585 C CG  . LEU A 1 641 ? -5.397  69.913  100.095 1.00 59.85  ?  622 LEU A CG  1 
ATOM   3586 C CD1 . LEU A 1 641 ? -4.168  69.110  100.542 1.00 55.89  ?  622 LEU A CD1 1 
ATOM   3587 C CD2 . LEU A 1 641 ? -6.681  69.193  100.435 1.00 55.10  ?  622 LEU A CD2 1 
ATOM   3588 N N   . CYS A 1 642 ? -2.594  71.879  98.614  1.00 57.57  ?  623 CYS A N   1 
ATOM   3589 C CA  . CYS A 1 642 ? -2.171  71.877  97.214  1.00 58.73  ?  623 CYS A CA  1 
ATOM   3590 C C   . CYS A 1 642 ? -2.607  70.581  96.515  1.00 60.06  ?  623 CYS A C   1 
ATOM   3591 O O   . CYS A 1 642 ? -2.154  69.491  96.881  1.00 61.75  ?  623 CYS A O   1 
ATOM   3592 C CB  . CYS A 1 642 ? -0.656  72.022  97.164  1.00 55.07  ?  623 CYS A CB  1 
ATOM   3593 S SG  . CYS A 1 642 ? -0.000  72.035  95.503  1.00 64.81  ?  623 CYS A SG  1 
ATOM   3594 N N   . THR A 1 643 ? -3.474  70.671  95.499  1.00 58.63  ?  624 THR A N   1 
ATOM   3595 C CA  . THR A 1 643 ? -3.704  69.521  94.625  1.00 55.97  ?  624 THR A CA  1 
ATOM   3596 C C   . THR A 1 643 ? -3.258  69.840  93.201  1.00 49.35  ?  624 THR A C   1 
ATOM   3597 O O   . THR A 1 643 ? -3.839  69.368  92.230  1.00 54.49  ?  624 THR A O   1 
ATOM   3598 C CB  . THR A 1 643 ? -5.164  69.076  94.617  1.00 55.75  ?  624 THR A CB  1 
ATOM   3599 O OG1 . THR A 1 643 ? -5.955  69.945  93.829  1.00 55.34  ?  624 THR A OG1 1 
ATOM   3600 C CG2 . THR A 1 643 ? -5.700  69.172  96.010  1.00 54.65  ?  624 THR A CG2 1 
ATOM   3601 N N   . LEU A 1 644 ? -2.274  70.695  93.078  1.00 58.42  ?  625 LEU A N   1 
ATOM   3602 C CA  . LEU A 1 644 ? -1.733  71.049  91.784  1.00 55.05  ?  625 LEU A CA  1 
ATOM   3603 C C   . LEU A 1 644 ? -1.240  69.791  91.075  1.00 56.81  ?  625 LEU A C   1 
ATOM   3604 O O   . LEU A 1 644 ? -0.548  68.976  91.682  1.00 55.31  ?  625 LEU A O   1 
ATOM   3605 C CB  . LEU A 1 644 ? -0.593  72.062  91.970  1.00 51.01  ?  625 LEU A CB  1 
ATOM   3606 C CG  . LEU A 1 644 ? -1.006  73.536  92.170  1.00 57.94  ?  625 LEU A CG  1 
ATOM   3607 C CD1 . LEU A 1 644 ? 0.130   74.419  92.681  1.00 52.28  ?  625 LEU A CD1 1 
ATOM   3608 C CD2 . LEU A 1 644 ? -1.562  74.143  90.876  1.00 48.76  ?  625 LEU A CD2 1 
ATOM   3609 N N   . PRO A 1 645 ? -1.584  69.587  89.815  1.00 60.45  ?  626 PRO A N   1 
ATOM   3610 C CA  . PRO A 1 645 ? -1.046  68.433  89.095  1.00 53.55  ?  626 PRO A CA  1 
ATOM   3611 C C   . PRO A 1 645 ? 0.476   68.395  89.136  1.00 56.78  ?  626 PRO A C   1 
ATOM   3612 O O   . PRO A 1 645 ? 1.141   69.434  89.187  1.00 60.22  ?  626 PRO A O   1 
ATOM   3613 C CB  . PRO A 1 645 ? -1.563  68.643  87.668  1.00 53.54  ?  626 PRO A CB  1 
ATOM   3614 C CG  . PRO A 1 645 ? -2.859  69.381  87.859  1.00 56.91  ?  626 PRO A CG  1 
ATOM   3615 C CD  . PRO A 1 645 ? -2.556  70.350  89.008  1.00 55.59  ?  626 PRO A CD  1 
ATOM   3616 N N   . LEU A 1 646 ? 1.026   67.166  89.110  1.00 58.96  ?  627 LEU A N   1 
ATOM   3617 C CA  . LEU A 1 646 ? 2.475   66.990  89.179  1.00 53.11  ?  627 LEU A CA  1 
ATOM   3618 C C   . LEU A 1 646 ? 3.183   67.660  88.013  1.00 57.85  ?  627 LEU A C   1 
ATOM   3619 O O   . LEU A 1 646 ? 4.322   68.122  88.157  1.00 59.56  ?  627 LEU A O   1 
ATOM   3620 C CB  . LEU A 1 646 ? 2.826   65.518  89.202  1.00 55.59  ?  627 LEU A CB  1 
ATOM   3621 C CG  . LEU A 1 646 ? 4.306   65.184  89.036  1.00 55.97  ?  627 LEU A CG  1 
ATOM   3622 C CD1 . LEU A 1 646 ? 5.165   65.717  90.176  1.00 54.22  ?  627 LEU A CD1 1 
ATOM   3623 C CD2 . LEU A 1 646 ? 4.440   63.696  88.937  1.00 55.20  ?  627 LEU A CD2 1 
ATOM   3624 N N   . GLY A 1 647 ? 2.532   67.729  86.850  1.00 61.00  ?  628 GLY A N   1 
ATOM   3625 C CA  . GLY A 1 647 ? 3.108   68.465  85.739  1.00 59.71  ?  628 GLY A CA  1 
ATOM   3626 C C   . GLY A 1 647 ? 3.222   69.950  86.007  1.00 57.52  ?  628 GLY A C   1 
ATOM   3627 O O   . GLY A 1 647 ? 4.117   70.611  85.476  1.00 58.19  ?  628 GLY A O   1 
ATOM   3628 N N   . VAL A 1 648 ? 2.318   70.497  86.822  1.00 58.96  ?  629 VAL A N   1 
ATOM   3629 C CA  . VAL A 1 648 ? 2.392   71.912  87.165  1.00 60.99  ?  629 VAL A CA  1 
ATOM   3630 C C   . VAL A 1 648 ? 3.539   72.157  88.137  1.00 56.45  ?  629 VAL A C   1 
ATOM   3631 O O   . VAL A 1 648 ? 4.372   73.044  87.917  1.00 57.10  ?  629 VAL A O   1 
ATOM   3632 C CB  . VAL A 1 648 ? 1.050   72.399  87.731  1.00 54.81  ?  629 VAL A CB  1 
ATOM   3633 C CG1 . VAL A 1 648 ? 1.210   73.782  88.260  1.00 45.30  ?  629 VAL A CG1 1 
ATOM   3634 C CG2 . VAL A 1 648 ? -0.048  72.308  86.663  1.00 48.69  ?  629 VAL A CG2 1 
ATOM   3635 N N   . LEU A 1 649 ? 3.609   71.347  89.208  1.00 50.38  ?  630 LEU A N   1 
ATOM   3636 C CA  . LEU A 1 649 ? 4.745   71.376  90.132  1.00 55.15  ?  630 LEU A CA  1 
ATOM   3637 C C   . LEU A 1 649 ? 6.076   71.228  89.404  1.00 58.83  ?  630 LEU A C   1 
ATOM   3638 O O   . LEU A 1 649 ? 7.088   71.799  89.826  1.00 59.79  ?  630 LEU A O   1 
ATOM   3639 C CB  . LEU A 1 649 ? 4.625   70.260  91.185  1.00 57.32  ?  630 LEU A CB  1 
ATOM   3640 C CG  . LEU A 1 649 ? 3.373   70.225  92.080  1.00 59.21  ?  630 LEU A CG  1 
ATOM   3641 C CD1 . LEU A 1 649 ? 3.412   69.094  93.127  1.00 52.26  ?  630 LEU A CD1 1 
ATOM   3642 C CD2 . LEU A 1 649 ? 3.160   71.573  92.754  1.00 50.40  ?  630 LEU A CD2 1 
ATOM   3643 N N   . LYS A 1 650 ? 6.098   70.451  88.322  1.00 59.61  ?  631 LYS A N   1 
ATOM   3644 C CA  . LYS A 1 650 ? 7.333   70.143  87.620  1.00 58.11  ?  631 LYS A CA  1 
ATOM   3645 C C   . LYS A 1 650 ? 7.817   71.302  86.771  1.00 63.14  ?  631 LYS A C   1 
ATOM   3646 O O   . LYS A 1 650 ? 9.014   71.350  86.452  1.00 66.01  ?  631 LYS A O   1 
ATOM   3647 C CB  . LYS A 1 650 ? 7.131   68.927  86.715  1.00 57.56  ?  631 LYS A CB  1 
ATOM   3648 C CG  . LYS A 1 650 ? 7.513   67.577  87.290  1.00 66.06  ?  631 LYS A CG  1 
ATOM   3649 C CD  . LYS A 1 650 ? 7.292   66.451  86.257  1.00 48.34  ?  631 LYS A CD  1 
ATOM   3650 C CE  . LYS A 1 650 ? 7.769   65.153  86.822  1.00 54.04  ?  631 LYS A CE  1 
ATOM   3651 N NZ  . LYS A 1 650 ? 9.257   64.959  86.764  1.00 56.94  ?  631 LYS A NZ  1 
ATOM   3652 N N   . GLN A 1 651 ? 6.903   72.210  86.391  1.00 62.91  ?  632 GLN A N   1 
ATOM   3653 C CA  . GLN A 1 651 ? 7.169   73.281  85.427  1.00 63.43  ?  632 GLN A CA  1 
ATOM   3654 C C   . GLN A 1 651 ? 8.348   74.157  85.807  1.00 71.10  ?  632 GLN A C   1 
ATOM   3655 O O   . GLN A 1 651 ? 8.419   74.681  86.925  1.00 74.53  ?  632 GLN A O   1 
ATOM   3656 C CB  . GLN A 1 651 ? 5.901   74.135  85.267  1.00 58.88  ?  632 GLN A CB  1 
ATOM   3657 C CG  . GLN A 1 651 ? 5.949   75.296  84.327  1.00 71.60  ?  632 GLN A CG  1 
ATOM   3658 C CD  . GLN A 1 651 ? 4.542   75.867  84.064  1.00 78.90  ?  632 GLN A CD  1 
ATOM   3659 O OE1 . GLN A 1 651 ? 3.542   75.337  84.568  1.00 73.18  ?  632 GLN A OE1 1 
ATOM   3660 N NE2 . GLN A 1 651 ? 4.473   76.995  83.332  1.00 76.19  ?  632 GLN A NE2 1 
ATOM   3661 N N   . GLN A 1 652 ? 9.243   74.360  84.839  1.00 78.05  ?  633 GLN A N   1 
ATOM   3662 C CA  . GLN A 1 652 ? 10.311  75.359  84.936  1.00 79.60  ?  633 GLN A CA  1 
ATOM   3663 C C   . GLN A 1 652 ? 10.287  76.271  83.712  1.00 84.29  ?  633 GLN A C   1 
ATOM   3664 O O   . GLN A 1 652 ? 10.369  75.777  82.568  1.00 87.91  ?  633 GLN A O   1 
ATOM   3665 C CB  . GLN A 1 652 ? 11.698  74.720  85.059  1.00 78.85  ?  633 GLN A CB  1 
ATOM   3666 C CG  . GLN A 1 652 ? 11.977  73.967  86.353  1.00 77.50  ?  633 GLN A CG  1 
ATOM   3667 C CD  . GLN A 1 652 ? 11.772  74.795  87.610  1.00 86.76  ?  633 GLN A CD  1 
ATOM   3668 O OE1 . GLN A 1 652 ? 12.428  75.827  87.815  1.00 90.78  ?  633 GLN A OE1 1 
ATOM   3669 N NE2 . GLN A 1 652 ? 10.850  74.348  88.464  1.00 84.75  ?  633 GLN A NE2 1 
ATOM   3670 N N   . PRO A 1 653 ? 10.216  77.608  83.895  1.00 88.80  ?  634 PRO A N   1 
ATOM   3671 C CA  . PRO A 1 653 ? 10.211  78.308  85.184  1.00 77.64  ?  634 PRO A CA  1 
ATOM   3672 C C   . PRO A 1 653 ? 8.876   78.094  85.883  1.00 75.42  ?  634 PRO A C   1 
ATOM   3673 O O   . PRO A 1 653 ? 7.884   77.845  85.192  1.00 75.78  ?  634 PRO A O   1 
ATOM   3674 C CB  . PRO A 1 653 ? 10.388  79.765  84.783  1.00 73.89  ?  634 PRO A CB  1 
ATOM   3675 C CG  . PRO A 1 653 ? 10.992  79.732  83.402  1.00 80.41  ?  634 PRO A CG  1 
ATOM   3676 C CD  . PRO A 1 653 ? 10.396  78.537  82.761  1.00 85.21  ?  634 PRO A CD  1 
ATOM   3677 N N   . PRO A 1 654 ? 8.874   78.167  87.210  1.00 67.06  ?  635 PRO A N   1 
ATOM   3678 C CA  . PRO A 1 654 ? 7.664   77.850  87.979  1.00 66.52  ?  635 PRO A CA  1 
ATOM   3679 C C   . PRO A 1 654 ? 6.416   78.566  87.489  1.00 65.76  ?  635 PRO A C   1 
ATOM   3680 O O   . PRO A 1 654 ? 6.446   79.739  87.140  1.00 72.00  ?  635 PRO A O   1 
ATOM   3681 C CB  . PRO A 1 654 ? 8.034   78.286  89.393  1.00 62.83  ?  635 PRO A CB  1 
ATOM   3682 C CG  . PRO A 1 654 ? 9.512   77.985  89.436  1.00 76.78  ?  635 PRO A CG  1 
ATOM   3683 C CD  . PRO A 1 654 ? 10.069  78.216  88.054  1.00 66.11  ?  635 PRO A CD  1 
ATOM   3684 N N   . ALA A 1 655 ? 5.302   77.839  87.448  1.00 67.34  ?  636 ALA A N   1 
ATOM   3685 C CA  . ALA A 1 655 ? 4.000   78.476  87.301  1.00 61.03  ?  636 ALA A CA  1 
ATOM   3686 C C   . ALA A 1 655 ? 3.465   78.961  88.625  1.00 64.81  ?  636 ALA A C   1 
ATOM   3687 O O   . ALA A 1 655 ? 2.493   79.728  88.637  1.00 66.38  ?  636 ALA A O   1 
ATOM   3688 C CB  . ALA A 1 655 ? 2.980   77.500  86.725  1.00 70.45  ?  636 ALA A CB  1 
ATOM   3689 N N   . VAL A 1 656 ? 4.036   78.461  89.727  1.00 61.35  ?  637 VAL A N   1 
ATOM   3690 C CA  . VAL A 1 656 ? 3.603   78.761  91.086  1.00 59.35  ?  637 VAL A CA  1 
ATOM   3691 C C   . VAL A 1 656 ? 4.838   78.808  91.960  1.00 60.34  ?  637 VAL A C   1 
ATOM   3692 O O   . VAL A 1 656 ? 5.679   77.907  91.919  1.00 63.41  ?  637 VAL A O   1 
ATOM   3693 C CB  . VAL A 1 656 ? 2.615   77.733  91.662  1.00 58.90  ?  637 VAL A CB  1 
ATOM   3694 C CG1 . VAL A 1 656 ? 2.475   77.965  93.161  1.00 55.41  ?  637 VAL A CG1 1 
ATOM   3695 C CG2 . VAL A 1 656 ? 1.262   77.840  90.989  1.00 56.21  ?  637 VAL A CG2 1 
ATOM   3696 N N   . GLN A 1 657 ? 4.955   79.864  92.733  1.00 66.21  ?  638 GLN A N   1 
ATOM   3697 C CA  . GLN A 1 657 ? 6.114   80.090  93.564  1.00 64.45  ?  638 GLN A CA  1 
ATOM   3698 C C   . GLN A 1 657 ? 5.749   79.752  95.002  1.00 67.61  ?  638 GLN A C   1 
ATOM   3699 O O   . GLN A 1 657 ? 4.689   80.167  95.502  1.00 65.12  ?  638 GLN A O   1 
ATOM   3700 C CB  . GLN A 1 657 ? 6.567   81.539  93.435  1.00 64.44  ?  638 GLN A CB  1 
ATOM   3701 C CG  . GLN A 1 657 ? 7.928   81.799  94.007  1.00 72.00  ?  638 GLN A CG  1 
ATOM   3702 C CD  . GLN A 1 657 ? 8.323   83.261  93.991  1.00 81.61  ?  638 GLN A CD  1 
ATOM   3703 O OE1 . GLN A 1 657 ? 9.283   83.637  94.667  1.00 79.97  ?  638 GLN A OE1 1 
ATOM   3704 N NE2 . GLN A 1 657 ? 7.614   84.095  93.181  1.00 88.25  ?  638 GLN A NE2 1 
ATOM   3705 N N   . PHE A 1 658 ? 6.608   78.997  95.668  1.00 59.19  ?  639 PHE A N   1 
ATOM   3706 C CA  . PHE A 1 658 ? 6.373   78.741  97.074  1.00 59.07  ?  639 PHE A CA  1 
ATOM   3707 C C   . PHE A 1 658 ? 7.293   79.629  97.904  1.00 60.98  ?  639 PHE A C   1 
ATOM   3708 O O   . PHE A 1 658 ? 8.459   79.863  97.541  1.00 59.36  ?  639 PHE A O   1 
ATOM   3709 C CB  . PHE A 1 658 ? 6.552   77.247  97.386  1.00 63.20  ?  639 PHE A CB  1 
ATOM   3710 C CG  . PHE A 1 658 ? 5.434   76.372  96.831  1.00 56.11  ?  639 PHE A CG  1 
ATOM   3711 C CD1 . PHE A 1 658 ? 4.286   76.132  97.574  1.00 56.79  ?  639 PHE A CD1 1 
ATOM   3712 C CD2 . PHE A 1 658 ? 5.523   75.825  95.570  1.00 59.45  ?  639 PHE A CD2 1 
ATOM   3713 C CE1 . PHE A 1 658 ? 3.256   75.361  97.087  1.00 53.02  ?  639 PHE A CE1 1 
ATOM   3714 C CE2 . PHE A 1 658 ? 4.486   75.043  95.069  1.00 59.24  ?  639 PHE A CE2 1 
ATOM   3715 C CZ  . PHE A 1 658 ? 3.349   74.822  95.831  1.00 53.53  ?  639 PHE A CZ  1 
ATOM   3716 N N   . VAL A 1 659 ? 6.734   80.181  98.982  1.00 57.52  ?  640 VAL A N   1 
ATOM   3717 C CA  . VAL A 1 659 ? 7.457   81.114  99.843  1.00 59.11  ?  640 VAL A CA  1 
ATOM   3718 C C   . VAL A 1 659 ? 7.267   80.682  101.293 1.00 62.12  ?  640 VAL A C   1 
ATOM   3719 O O   . VAL A 1 659 ? 6.161   80.814  101.853 1.00 65.26  ?  640 VAL A O   1 
ATOM   3720 C CB  . VAL A 1 659 ? 7.003   82.579  99.641  1.00 66.24  ?  640 VAL A CB  1 
ATOM   3721 C CG1 . VAL A 1 659 ? 7.793   83.477  100.533 1.00 60.56  ?  640 VAL A CG1 1 
ATOM   3722 C CG2 . VAL A 1 659 ? 7.184   83.060  98.201  1.00 61.48  ?  640 VAL A CG2 1 
ATOM   3723 N N   . PRO A 1 660 ? 8.313   80.155  101.946 1.00 61.92  ?  641 PRO A N   1 
ATOM   3724 C CA  . PRO A 1 660 ? 9.656   79.909  101.386 1.00 57.98  ?  641 PRO A CA  1 
ATOM   3725 C C   . PRO A 1 660 ? 9.663   78.739  100.379 1.00 60.72  ?  641 PRO A C   1 
ATOM   3726 O O   . PRO A 1 660 ? 8.695   77.967  100.317 1.00 61.38  ?  641 PRO A O   1 
ATOM   3727 C CB  . PRO A 1 660 ? 10.493  79.594  102.646 1.00 52.82  ?  641 PRO A CB  1 
ATOM   3728 C CG  . PRO A 1 660 ? 9.520   79.036  103.613 1.00 47.13  ?  641 PRO A CG  1 
ATOM   3729 C CD  . PRO A 1 660 ? 8.185   79.667  103.336 1.00 54.35  ?  641 PRO A CD  1 
ATOM   3730 N N   . PRO A 1 661 ? 10.731  78.585  99.602  1.00 62.24  ?  642 PRO A N   1 
ATOM   3731 C CA  . PRO A 1 661 ? 10.745  77.493  98.618  1.00 55.95  ?  642 PRO A CA  1 
ATOM   3732 C C   . PRO A 1 661 ? 10.598  76.137  99.305  1.00 64.09  ?  642 PRO A C   1 
ATOM   3733 O O   . PRO A 1 661 ? 10.973  75.959  100.471 1.00 63.11  ?  642 PRO A O   1 
ATOM   3734 C CB  . PRO A 1 661 ? 12.118  77.623  97.947  1.00 53.83  ?  642 PRO A CB  1 
ATOM   3735 C CG  . PRO A 1 661 ? 12.693  78.907  98.424  1.00 56.88  ?  642 PRO A CG  1 
ATOM   3736 C CD  . PRO A 1 661 ? 12.061  79.194  99.757  1.00 55.80  ?  642 PRO A CD  1 
ATOM   3737 N N   . LEU A 1 662 ? 10.033  75.179  98.566  1.00 63.44  ?  643 LEU A N   1 
ATOM   3738 C CA  . LEU A 1 662 ? 9.892   73.813  99.048  1.00 56.79  ?  643 LEU A CA  1 
ATOM   3739 C C   . LEU A 1 662 ? 11.270  73.175  99.273  1.00 57.69  ?  643 LEU A C   1 
ATOM   3740 O O   . LEU A 1 662 ? 12.214  73.416  98.512  1.00 59.97  ?  643 LEU A O   1 
ATOM   3741 C CB  . LEU A 1 662 ? 9.097   72.985  98.038  1.00 57.89  ?  643 LEU A CB  1 
ATOM   3742 C CG  . LEU A 1 662 ? 7.699   73.504  97.715  1.00 57.40  ?  643 LEU A CG  1 
ATOM   3743 C CD1 . LEU A 1 662 ? 7.080   72.739  96.583  1.00 47.14  ?  643 LEU A CD1 1 
ATOM   3744 C CD2 . LEU A 1 662 ? 6.815   73.436  98.942  1.00 57.25  ?  643 LEU A CD2 1 
ATOM   3745 N N   . PRO A 1 663 ? 11.409  72.345  100.298 1.00 54.97  ?  644 PRO A N   1 
ATOM   3746 C CA  . PRO A 1 663 ? 12.715  71.743  100.581 1.00 54.78  ?  644 PRO A CA  1 
ATOM   3747 C C   . PRO A 1 663 ? 13.157  70.812  99.465  1.00 60.51  ?  644 PRO A C   1 
ATOM   3748 O O   . PRO A 1 663 ? 12.357  70.325  98.667  1.00 59.95  ?  644 PRO A O   1 
ATOM   3749 C CB  . PRO A 1 663 ? 12.475  70.960  101.873 1.00 55.42  ?  644 PRO A CB  1 
ATOM   3750 C CG  . PRO A 1 663 ? 10.992  70.731  101.909 1.00 54.51  ?  644 PRO A CG  1 
ATOM   3751 C CD  . PRO A 1 663 ? 10.367  71.914  101.248 1.00 57.62  ?  644 PRO A CD  1 
ATOM   3752 N N   . GLU A 1 664 ? 14.468  70.557  99.439  1.00 60.02  ?  645 GLU A N   1 
ATOM   3753 C CA  . GLU A 1 664 ? 15.053  69.624  98.476  1.00 64.75  ?  645 GLU A CA  1 
ATOM   3754 C C   . GLU A 1 664 ? 14.318  68.275  98.456  1.00 68.76  ?  645 GLU A C   1 
ATOM   3755 O O   . GLU A 1 664 ? 14.028  67.729  97.379  1.00 67.00  ?  645 GLU A O   1 
ATOM   3756 C CB  . GLU A 1 664 ? 16.535  69.420  98.801  1.00 70.56  ?  645 GLU A CB  1 
ATOM   3757 C CG  . GLU A 1 664 ? 17.384  68.622  97.782  1.00 76.32  ?  645 GLU A CG  1 
ATOM   3758 C CD  . GLU A 1 664 ? 17.247  67.066  97.903  1.00 92.97  ?  645 GLU A CD  1 
ATOM   3759 O OE1 . GLU A 1 664 ? 16.899  66.524  98.993  1.00 93.11  ?  645 GLU A OE1 1 
ATOM   3760 O OE2 . GLU A 1 664 ? 17.542  66.373  96.898  1.00 93.94  ?  645 GLU A OE2 1 
ATOM   3761 N N   . TRP A 1 665 ? 14.032  67.702  99.628  1.00 63.10  ?  646 TRP A N   1 
ATOM   3762 C CA  . TRP A 1 665 ? 13.438  66.375  99.623  1.00 57.38  ?  646 TRP A CA  1 
ATOM   3763 C C   . TRP A 1 665 ? 12.105  66.367  98.897  1.00 58.60  ?  646 TRP A C   1 
ATOM   3764 O O   . TRP A 1 665 ? 11.716  65.340  98.344  1.00 66.75  ?  646 TRP A O   1 
ATOM   3765 C CB  . TRP A 1 665 ? 13.289  65.833  101.042 1.00 44.49  ?  646 TRP A CB  1 
ATOM   3766 C CG  . TRP A 1 665 ? 12.423  66.623  101.967 1.00 55.51  ?  646 TRP A CG  1 
ATOM   3767 C CD1 . TRP A 1 665 ? 12.850  67.535  102.888 1.00 55.80  ?  646 TRP A CD1 1 
ATOM   3768 C CD2 . TRP A 1 665 ? 10.985  66.547  102.123 1.00 54.37  ?  646 TRP A CD2 1 
ATOM   3769 N NE1 . TRP A 1 665 ? 11.779  68.047  103.585 1.00 54.66  ?  646 TRP A NE1 1 
ATOM   3770 C CE2 . TRP A 1 665 ? 10.626  67.463  103.143 1.00 52.13  ?  646 TRP A CE2 1 
ATOM   3771 C CE3 . TRP A 1 665 ? 9.976   65.809  101.498 1.00 56.23  ?  646 TRP A CE3 1 
ATOM   3772 C CZ2 . TRP A 1 665 ? 9.301   67.667  103.549 1.00 49.12  ?  646 TRP A CZ2 1 
ATOM   3773 C CZ3 . TRP A 1 665 ? 8.648   66.017  101.905 1.00 60.17  ?  646 TRP A CZ3 1 
ATOM   3774 C CH2 . TRP A 1 665 ? 8.330   66.943  102.923 1.00 57.60  ?  646 TRP A CH2 1 
ATOM   3775 N N   . LYS A 1 666 ? 11.401  67.487  98.862  1.00 59.20  ?  647 LYS A N   1 
ATOM   3776 C CA  . LYS A 1 666 ? 10.170  67.498  98.087  1.00 60.57  ?  647 LYS A CA  1 
ATOM   3777 C C   . LYS A 1 666 ? 10.413  67.862  96.624  1.00 60.11  ?  647 LYS A C   1 
ATOM   3778 O O   . LYS A 1 666 ? 9.770   67.293  95.748  1.00 64.78  ?  647 LYS A O   1 
ATOM   3779 C CB  . LYS A 1 666 ? 9.158   68.449  98.728  1.00 53.58  ?  647 LYS A CB  1 
ATOM   3780 C CG  . LYS A 1 666 ? 7.915   68.713  97.910  1.00 53.26  ?  647 LYS A CG  1 
ATOM   3781 C CD  . LYS A 1 666 ? 6.821   67.698  98.177  1.00 60.72  ?  647 LYS A CD  1 
ATOM   3782 C CE  . LYS A 1 666 ? 6.455   67.620  99.658  1.00 58.05  ?  647 LYS A CE  1 
ATOM   3783 N NZ  . LYS A 1 666 ? 5.055   67.117  99.892  1.00 57.12  ?  647 LYS A NZ  1 
ATOM   3784 N N   . THR A 1 667 ? 11.331  68.785  96.320  1.00 60.53  ?  648 THR A N   1 
ATOM   3785 C CA  . THR A 1 667 ? 11.562  69.125  94.913  1.00 63.28  ?  648 THR A CA  1 
ATOM   3786 C C   . THR A 1 667 ? 12.202  67.957  94.173  1.00 66.14  ?  648 THR A C   1 
ATOM   3787 O O   . THR A 1 667 ? 11.887  67.719  93.000  1.00 63.35  ?  648 THR A O   1 
ATOM   3788 C CB  . THR A 1 667 ? 12.433  70.392  94.748  1.00 62.97  ?  648 THR A CB  1 
ATOM   3789 O OG1 . THR A 1 667 ? 13.815  70.059  94.941  1.00 74.38  ?  648 THR A OG1 1 
ATOM   3790 C CG2 . THR A 1 667 ? 12.049  71.504  95.705  1.00 47.99  ?  648 THR A CG2 1 
ATOM   3791 N N   . SER A 1 668 ? 13.077  67.192  94.853  1.00 66.02  ?  649 SER A N   1 
ATOM   3792 C CA  . SER A 1 668 ? 13.723  66.054  94.198  1.00 66.40  ?  649 SER A CA  1 
ATOM   3793 C C   . SER A 1 668 ? 12.735  64.944  93.889  1.00 63.58  ?  649 SER A C   1 
ATOM   3794 O O   . SER A 1 668 ? 12.839  64.307  92.838  1.00 66.17  ?  649 SER A O   1 
ATOM   3795 C CB  . SER A 1 668 ? 14.865  65.514  95.038  1.00 64.93  ?  649 SER A CB  1 
ATOM   3796 O OG  . SER A 1 668 ? 16.000  66.336  94.870  1.00 74.98  ?  649 SER A OG  1 
ATOM   3797 N N   . ALA A 1 669 ? 11.762  64.704  94.772  1.00 58.29  ?  650 ALA A N   1 
ATOM   3798 C CA  . ALA A 1 669 ? 10.682  63.795  94.407  1.00 59.34  ?  650 ALA A CA  1 
ATOM   3799 C C   . ALA A 1 669 ? 9.946   64.291  93.165  1.00 65.24  ?  650 ALA A C   1 
ATOM   3800 O O   . ALA A 1 669 ? 9.598   63.494  92.279  1.00 66.80  ?  650 ALA A O   1 
ATOM   3801 C CB  . ALA A 1 669 ? 9.709   63.614  95.568  1.00 55.17  ?  650 ALA A CB  1 
ATOM   3802 N N   . VAL A 1 670 ? 9.719   65.605  93.071  1.00 56.22  ?  651 VAL A N   1 
ATOM   3803 C CA  . VAL A 1 670 ? 9.024   66.149  91.911  1.00 60.39  ?  651 VAL A CA  1 
ATOM   3804 C C   . VAL A 1 670 ? 9.844   65.930  90.629  1.00 64.31  ?  651 VAL A C   1 
ATOM   3805 O O   . VAL A 1 670 ? 9.286   65.627  89.565  1.00 58.80  ?  651 VAL A O   1 
ATOM   3806 C CB  . VAL A 1 670 ? 8.679   67.636  92.156  1.00 56.13  ?  651 VAL A CB  1 
ATOM   3807 C CG1 . VAL A 1 670 ? 8.179   68.316  90.888  1.00 55.37  ?  651 VAL A CG1 1 
ATOM   3808 C CG2 . VAL A 1 670 ? 7.596   67.747  93.191  1.00 56.48  ?  651 VAL A CG2 1 
ATOM   3809 N N   . GLN A 1 671 ? 11.175  66.050  90.709  1.00 61.19  ?  652 GLN A N   1 
ATOM   3810 C CA  . GLN A 1 671 ? 11.998  65.799  89.530  1.00 64.13  ?  652 GLN A CA  1 
ATOM   3811 C C   . GLN A 1 671 ? 12.055  64.314  89.173  1.00 66.49  ?  652 GLN A C   1 
ATOM   3812 O O   . GLN A 1 671 ? 12.062  63.949  87.995  1.00 65.30  ?  652 GLN A O   1 
ATOM   3813 C CB  . GLN A 1 671 ? 13.406  66.326  89.755  1.00 70.15  ?  652 GLN A CB  1 
ATOM   3814 C CG  . GLN A 1 671 ? 13.555  67.791  89.467  1.00 76.78  ?  652 GLN A CG  1 
ATOM   3815 C CD  . GLN A 1 671 ? 14.758  68.396  90.173  1.00 86.49  ?  652 GLN A CD  1 
ATOM   3816 O OE1 . GLN A 1 671 ? 15.860  67.834  90.152  1.00 88.43  ?  652 GLN A OE1 1 
ATOM   3817 N NE2 . GLN A 1 671 ? 14.546  69.541  90.823  1.00 85.90  ?  652 GLN A NE2 1 
ATOM   3818 N N   . ARG A 1 672 ? 12.120  63.445  90.173  1.00 64.44  ?  653 ARG A N   1 
ATOM   3819 C CA  . ARG A 1 672 ? 12.268  62.029  89.887  1.00 60.24  ?  653 ARG A CA  1 
ATOM   3820 C C   . ARG A 1 672 ? 10.998  61.442  89.310  1.00 61.75  ?  653 ARG A C   1 
ATOM   3821 O O   . ARG A 1 672 ? 11.053  60.628  88.376  1.00 67.82  ?  653 ARG A O   1 
ATOM   3822 C CB  . ARG A 1 672 ? 12.650  61.280  91.150  1.00 62.13  ?  653 ARG A CB  1 
ATOM   3823 C CG  . ARG A 1 672 ? 14.091  61.430  91.483  1.00 62.16  ?  653 ARG A CG  1 
ATOM   3824 C CD  . ARG A 1 672 ? 14.476  60.457  92.530  1.00 58.12  ?  653 ARG A CD  1 
ATOM   3825 N NE  . ARG A 1 672 ? 13.666  60.570  93.733  1.00 59.46  ?  653 ARG A NE  1 
ATOM   3826 C CZ  . ARG A 1 672 ? 13.991  61.366  94.734  1.00 60.63  ?  653 ARG A CZ  1 
ATOM   3827 N NH1 . ARG A 1 672 ? 15.079  62.111  94.607  1.00 61.93  ?  653 ARG A NH1 1 
ATOM   3828 N NH2 . ARG A 1 672 ? 13.237  61.428  95.831  1.00 58.98  ?  653 ARG A NH2 1 
ATOM   3829 N N   . MET A 1 673 ? 9.851   61.814  89.862  1.00 57.72  ?  654 MET A N   1 
ATOM   3830 C CA  . MET A 1 673 ? 8.623   61.203  89.397  1.00 62.81  ?  654 MET A CA  1 
ATOM   3831 C C   . MET A 1 673 ? 8.403   61.487  87.923  1.00 60.63  ?  654 MET A C   1 
ATOM   3832 O O   . MET A 1 673 ? 8.964   62.408  87.343  1.00 65.45  ?  654 MET A O   1 
ATOM   3833 C CB  . MET A 1 673 ? 7.431   61.684  90.195  1.00 59.56  ?  654 MET A CB  1 
ATOM   3834 C CG  . MET A 1 673 ? 7.301   60.908  91.456  1.00 72.26  ?  654 MET A CG  1 
ATOM   3835 S SD  . MET A 1 673 ? 5.927   61.430  92.476  1.00 79.76  ?  654 MET A SD  1 
ATOM   3836 C CE  . MET A 1 673 ? 4.604   60.901  91.373  1.00 65.50  ?  654 MET A CE  1 
ATOM   3837 N N   . GLY A 1 674 ? 7.614   60.626  87.307  1.00 60.22  ?  655 GLY A N   1 
ATOM   3838 C CA  . GLY A 1 674 ? 7.295   60.745  85.910  1.00 58.37  ?  655 GLY A CA  1 
ATOM   3839 C C   . GLY A 1 674 ? 5.916   61.343  85.782  1.00 60.75  ?  655 GLY A C   1 
ATOM   3840 O O   . GLY A 1 674 ? 4.990   60.995  86.530  1.00 54.61  ?  655 GLY A O   1 
ATOM   3841 N N   . PHE A 1 675 ? 5.782   62.271  84.846  1.00 56.57  ?  656 PHE A N   1 
ATOM   3842 C CA  . PHE A 1 675 ? 4.464   62.738  84.464  1.00 62.01  ?  656 PHE A CA  1 
ATOM   3843 C C   . PHE A 1 675 ? 4.310   62.463  82.982  1.00 63.22  ?  656 PHE A C   1 
ATOM   3844 O O   . PHE A 1 675 ? 4.995   63.075  82.152  1.00 58.78  ?  656 PHE A O   1 
ATOM   3845 C CB  . PHE A 1 675 ? 4.243   64.214  84.790  1.00 57.73  ?  656 PHE A CB  1 
ATOM   3846 C CG  . PHE A 1 675 ? 2.806   64.564  84.950  1.00 54.37  ?  656 PHE A CG  1 
ATOM   3847 C CD1 . PHE A 1 675 ? 2.013   63.849  85.812  1.00 54.66  ?  656 PHE A CD1 1 
ATOM   3848 C CD2 . PHE A 1 675 ? 2.237   65.572  84.207  1.00 56.53  ?  656 PHE A CD2 1 
ATOM   3849 C CE1 . PHE A 1 675 ? 0.683   64.163  85.940  1.00 57.92  ?  656 PHE A CE1 1 
ATOM   3850 C CE2 . PHE A 1 675 ? 0.905   65.890  84.344  1.00 57.10  ?  656 PHE A CE2 1 
ATOM   3851 C CZ  . PHE A 1 675 ? 0.129   65.189  85.207  1.00 54.97  ?  656 PHE A CZ  1 
ATOM   3852 N N   . GLY A 1 676 ? 3.411   61.545  82.661  1.00 59.08  ?  657 GLY A N   1 
ATOM   3853 C CA  . GLY A 1 676 ? 3.201   61.124  81.298  1.00 60.16  ?  657 GLY A CA  1 
ATOM   3854 C C   . GLY A 1 676 ? 2.154   61.920  80.557  1.00 56.50  ?  657 GLY A C   1 
ATOM   3855 O O   . GLY A 1 676 ? 1.741   63.004  80.964  1.00 58.17  ?  657 GLY A O   1 
ATOM   3856 N N   . ASN A 1 677 ? 1.696   61.339  79.459  1.00 63.75  ?  658 ASN A N   1 
ATOM   3857 C CA  . ASN A 1 677 ? 0.943   62.052  78.445  1.00 65.16  ?  658 ASN A CA  1 
ATOM   3858 C C   . ASN A 1 677 ? 0.213   61.037  77.582  1.00 61.01  ?  658 ASN A C   1 
ATOM   3859 O O   . ASN A 1 677 ? 0.751   59.969  77.295  1.00 65.29  ?  658 ASN A O   1 
ATOM   3860 C CB  . ASN A 1 677 ? 1.882   62.909  77.599  1.00 63.39  ?  658 ASN A CB  1 
ATOM   3861 C CG  . ASN A 1 677 ? 1.147   63.848  76.692  1.00 63.96  ?  658 ASN A CG  1 
ATOM   3862 O OD1 . ASN A 1 677 ? -0.080  64.020  76.791  1.00 59.67  ?  658 ASN A OD1 1 
ATOM   3863 N ND2 . ASN A 1 677 ? 1.893   64.455  75.777  1.00 67.03  ?  658 ASN A ND2 1 
ATOM   3864 N N   . LEU A 1 678 ? -0.987  61.413  77.139  1.00 62.55  ?  659 LEU A N   1 
ATOM   3865 C CA  . LEU A 1 678 ? -1.969  60.535  76.521  1.00 63.34  ?  659 LEU A CA  1 
ATOM   3866 C C   . LEU A 1 678 ? -3.133  61.365  75.993  1.00 71.30  ?  659 LEU A C   1 
ATOM   3867 O O   . LEU A 1 678 ? -3.748  62.085  76.782  1.00 75.83  ?  659 LEU A O   1 
ATOM   3868 C CB  . LEU A 1 678 ? -2.468  59.529  77.552  1.00 66.77  ?  659 LEU A CB  1 
ATOM   3869 C CG  . LEU A 1 678 ? -3.818  58.868  77.309  1.00 69.64  ?  659 LEU A CG  1 
ATOM   3870 C CD1 . LEU A 1 678 ? -3.706  57.978  76.093  1.00 77.73  ?  659 LEU A CD1 1 
ATOM   3871 C CD2 . LEU A 1 678 ? -4.202  58.039  78.508  1.00 71.31  ?  659 LEU A CD2 1 
ATOM   3872 N N   . ASN A 1 679 ? -3.472  61.283  74.694  1.00 72.61  ?  660 ASN A N   1 
ATOM   3873 C CA  . ASN A 1 679 ? -4.471  62.181  74.108  1.00 71.50  ?  660 ASN A CA  1 
ATOM   3874 C C   . ASN A 1 679 ? -5.588  61.433  73.390  1.00 74.08  ?  660 ASN A C   1 
ATOM   3875 O O   . ASN A 1 679 ? -5.422  60.284  72.979  1.00 75.48  ?  660 ASN A O   1 
ATOM   3876 C CB  . ASN A 1 679 ? -3.821  63.146  73.157  1.00 68.02  ?  660 ASN A CB  1 
ATOM   3877 C CG  . ASN A 1 679 ? -3.246  64.305  73.879  1.00 71.24  ?  660 ASN A CG  1 
ATOM   3878 O OD1 . ASN A 1 679 ? -3.944  64.947  74.655  1.00 71.02  ?  660 ASN A OD1 1 
ATOM   3879 N ND2 . ASN A 1 679 ? -1.960  64.570  73.671  1.00 71.14  ?  660 ASN A ND2 1 
ATOM   3880 N N   . LYS A 1 680 ? -6.744  62.101  73.246  1.00 67.78  ?  661 LYS A N   1 
ATOM   3881 C CA  . LYS A 1 680 ? -7.934  61.497  72.656  1.00 67.96  ?  661 LYS A CA  1 
ATOM   3882 C C   . LYS A 1 680 ? -8.420  62.317  71.474  1.00 77.71  ?  661 LYS A C   1 
ATOM   3883 O O   . LYS A 1 680 ? -8.269  63.540  71.453  1.00 81.80  ?  661 LYS A O   1 
ATOM   3884 C CB  . LYS A 1 680 ? -9.080  61.375  73.647  1.00 67.03  ?  661 LYS A CB  1 
ATOM   3885 C CG  . LYS A 1 680 ? -8.726  60.591  74.884  1.00 70.64  ?  661 LYS A CG  1 
ATOM   3886 C CD  . LYS A 1 680 ? -9.915  60.332  75.795  1.00 61.34  ?  661 LYS A CD  1 
ATOM   3887 C CE  . LYS A 1 680 ? -9.440  59.503  76.964  1.00 67.33  ?  661 LYS A CE  1 
ATOM   3888 N NZ  . LYS A 1 680 ? -10.535 59.017  77.824  1.00 77.01  ?  661 LYS A NZ  1 
ATOM   3889 N N   . VAL A 1 681 ? -9.002  61.637  70.482  1.00 77.97  ?  662 VAL A N   1 
ATOM   3890 C CA  . VAL A 1 681 ? -9.741  62.293  69.413  1.00 75.51  ?  662 VAL A CA  1 
ATOM   3891 C C   . VAL A 1 681 ? -11.179 61.820  69.488  1.00 77.68  ?  662 VAL A C   1 
ATOM   3892 O O   . VAL A 1 681 ? -11.448 60.623  69.342  1.00 83.37  ?  662 VAL A O   1 
ATOM   3893 C CB  . VAL A 1 681 ? -9.149  62.004  68.037  1.00 72.73  ?  662 VAL A CB  1 
ATOM   3894 C CG1 . VAL A 1 681 ? -9.798  62.910  67.042  1.00 72.50  ?  662 VAL A CG1 1 
ATOM   3895 C CG2 . VAL A 1 681 ? -7.665  62.208  68.065  1.00 74.59  ?  662 VAL A CG2 1 
ATOM   3896 N N   . VAL A 1 682 ? -12.094 62.742  69.741  1.00 77.94  ?  663 VAL A N   1 
ATOM   3897 C CA  . VAL A 1 682 ? -13.515 62.430  69.761  1.00 83.37  ?  663 VAL A CA  1 
ATOM   3898 C C   . VAL A 1 682 ? -14.057 62.652  68.362  1.00 91.35  ?  663 VAL A C   1 
ATOM   3899 O O   . VAL A 1 682 ? -13.883 63.736  67.789  1.00 86.30  ?  663 VAL A O   1 
ATOM   3900 C CB  . VAL A 1 682 ? -14.268 63.295  70.782  1.00 83.95  ?  663 VAL A CB  1 
ATOM   3901 C CG1 . VAL A 1 682 ? -15.740 62.976  70.724  1.00 85.58  ?  663 VAL A CG1 1 
ATOM   3902 C CG2 . VAL A 1 682 ? -13.762 63.029  72.161  1.00 84.34  ?  663 VAL A CG2 1 
ATOM   3903 N N   . LEU A 1 683 ? -14.697 61.618  67.803  1.00 97.36  ?  664 LEU A N   1 
ATOM   3904 C CA  . LEU A 1 683 ? -15.217 61.637  66.440  1.00 90.43  ?  664 LEU A CA  1 
ATOM   3905 C C   . LEU A 1 683 ? -16.731 61.516  66.494  1.00 94.17  ?  664 LEU A C   1 
ATOM   3906 O O   . LEU A 1 683 ? -17.268 60.502  66.965  1.00 93.20  ?  664 LEU A O   1 
ATOM   3907 C CB  . LEU A 1 683 ? -14.615 60.512  65.610  1.00 89.10  ?  664 LEU A CB  1 
ATOM   3908 C CG  . LEU A 1 683 ? -13.170 60.853  65.276  1.00 86.91  ?  664 LEU A CG  1 
ATOM   3909 C CD1 . LEU A 1 683 ? -12.306 59.580  65.185  1.00 92.31  ?  664 LEU A CD1 1 
ATOM   3910 C CD2 . LEU A 1 683 ? -13.105 61.669  64.030  1.00 86.33  ?  664 LEU A CD2 1 
ATOM   3911 N N   . CYS A 1 684 ? -17.412 62.550  66.016  1.00 94.68  ?  665 CYS A N   1 
ATOM   3912 C CA  . CYS A 1 684 ? -18.858 62.674  66.138  1.00 100.69 ?  665 CYS A CA  1 
ATOM   3913 C C   . CYS A 1 684 ? -19.497 62.484  64.766  1.00 107.11 ?  665 CYS A C   1 
ATOM   3914 O O   . CYS A 1 684 ? -19.312 63.308  63.857  1.00 104.48 ?  665 CYS A O   1 
ATOM   3915 C CB  . CYS A 1 684 ? -19.214 64.021  66.754  1.00 102.21 ?  665 CYS A CB  1 
ATOM   3916 S SG  . CYS A 1 684 ? -18.852 64.029  68.515  1.00 105.60 ?  665 CYS A SG  1 
ATOM   3917 N N   . PHE A 1 685 ? -20.243 61.393  64.619  1.00 108.40 ?  666 PHE A N   1 
ATOM   3918 C CA  . PHE A 1 685 ? -20.851 61.015  63.353  1.00 108.30 ?  666 PHE A CA  1 
ATOM   3919 C C   . PHE A 1 685 ? -22.370 61.099  63.451  1.00 112.48 ?  666 PHE A C   1 
ATOM   3920 O O   . PHE A 1 685 ? -22.938 61.276  64.533  1.00 111.36 ?  666 PHE A O   1 
ATOM   3921 C CB  . PHE A 1 685 ? -20.411 59.604  62.952  1.00 106.65 ?  666 PHE A CB  1 
ATOM   3922 C CG  . PHE A 1 685 ? -18.952 59.493  62.663  1.00 99.44  ?  666 PHE A CG  1 
ATOM   3923 C CD1 . PHE A 1 685 ? -18.373 60.269  61.673  1.00 98.73  ?  666 PHE A CD1 1 
ATOM   3924 C CD2 . PHE A 1 685 ? -18.160 58.619  63.383  1.00 95.16  ?  666 PHE A CD2 1 
ATOM   3925 C CE1 . PHE A 1 685 ? -17.031 60.173  61.404  1.00 99.40  ?  666 PHE A CE1 1 
ATOM   3926 C CE2 . PHE A 1 685 ? -16.816 58.520  63.120  1.00 95.39  ?  666 PHE A CE2 1 
ATOM   3927 C CZ  . PHE A 1 685 ? -16.249 59.295  62.128  1.00 96.92  ?  666 PHE A CZ  1 
ATOM   3928 N N   . ASP A 1 686 ? -23.025 60.975  62.292  1.00 115.00 ?  667 ASP A N   1 
ATOM   3929 C CA  . ASP A 1 686 ? -24.481 60.958  62.198  1.00 111.40 ?  667 ASP A CA  1 
ATOM   3930 C C   . ASP A 1 686 ? -25.059 59.557  62.021  1.00 114.19 ?  667 ASP A C   1 
ATOM   3931 O O   . ASP A 1 686 ? -26.283 59.418  61.953  1.00 116.46 ?  667 ASP A O   1 
ATOM   3932 C CB  . ASP A 1 686 ? -24.939 61.858  61.048  1.00 113.41 ?  667 ASP A CB  1 
ATOM   3933 C CG  . ASP A 1 686 ? -24.286 61.491  59.731  1.00 121.49 ?  667 ASP A CG  1 
ATOM   3934 O OD1 . ASP A 1 686 ? -24.992 61.480  58.697  1.00 125.48 ?  667 ASP A OD1 1 
ATOM   3935 O OD2 . ASP A 1 686 ? -23.066 61.203  59.734  1.00 121.07 ?  667 ASP A OD2 1 
ATOM   3936 N N   . ARG A 1 687 ? -24.222 58.520  61.953  1.00 112.49 ?  668 ARG A N   1 
ATOM   3937 C CA  . ARG A 1 687 ? -24.720 57.156  61.858  1.00 107.17 ?  668 ARG A CA  1 
ATOM   3938 C C   . ARG A 1 687 ? -23.650 56.185  62.320  1.00 103.78 ?  668 ARG A C   1 
ATOM   3939 O O   . ARG A 1 687 ? -22.475 56.328  61.966  1.00 104.21 ?  668 ARG A O   1 
ATOM   3940 C CB  . ARG A 1 687 ? -25.138 56.806  60.427  1.00 115.47 ?  668 ARG A CB  1 
ATOM   3941 C CG  . ARG A 1 687 ? -24.106 57.138  59.348  1.00 114.05 ?  668 ARG A CG  1 
ATOM   3942 C CD  . ARG A 1 687 ? -24.719 56.866  57.983  1.00 120.92 ?  668 ARG A CD  1 
ATOM   3943 N NE  . ARG A 1 687 ? -23.947 57.384  56.852  1.00 126.53 ?  668 ARG A NE  1 
ATOM   3944 C CZ  . ARG A 1 687 ? -24.221 58.521  56.212  1.00 123.35 ?  668 ARG A CZ  1 
ATOM   3945 N NH1 . ARG A 1 687 ? -25.241 59.283  56.606  1.00 115.30 ?  668 ARG A NH1 1 
ATOM   3946 N NH2 . ARG A 1 687 ? -23.469 58.900  55.179  1.00 119.33 ?  668 ARG A NH2 1 
ATOM   3947 N N   . VAL A 1 688 ? -24.073 55.182  63.090  1.00 99.58  ?  669 VAL A N   1 
ATOM   3948 C CA  . VAL A 1 688 ? -23.190 54.065  63.393  1.00 98.87  ?  669 VAL A CA  1 
ATOM   3949 C C   . VAL A 1 688 ? -22.835 53.335  62.104  1.00 101.38 ?  669 VAL A C   1 
ATOM   3950 O O   . VAL A 1 688 ? -23.710 52.943  61.321  1.00 102.39 ?  669 VAL A O   1 
ATOM   3951 C CB  . VAL A 1 688 ? -23.851 53.118  64.403  1.00 95.50  ?  669 VAL A CB  1 
ATOM   3952 C CG1 . VAL A 1 688 ? -22.850 52.073  64.875  1.00 96.91  ?  669 VAL A CG1 1 
ATOM   3953 C CG2 . VAL A 1 688 ? -24.417 53.891  65.568  1.00 93.58  ?  669 VAL A CG2 1 
ATOM   3954 N N   . PHE A 1 689 ? -21.540 53.153  61.873  1.00 97.40  ?  670 PHE A N   1 
ATOM   3955 C CA  . PHE A 1 689 ? -21.070 52.391  60.734  1.00 93.37  ?  670 PHE A CA  1 
ATOM   3956 C C   . PHE A 1 689 ? -20.080 51.320  61.150  1.00 93.54  ?  670 PHE A C   1 
ATOM   3957 O O   . PHE A 1 689 ? -19.406 50.746  60.289  1.00 98.20  ?  670 PHE A O   1 
ATOM   3958 C CB  . PHE A 1 689 ? -20.447 53.323  59.702  1.00 95.94  ?  670 PHE A CB  1 
ATOM   3959 C CG  . PHE A 1 689 ? -19.210 54.002  60.175  1.00 99.09  ?  670 PHE A CG  1 
ATOM   3960 C CD1 . PHE A 1 689 ? -18.007 53.322  60.256  1.00 101.84 ?  670 PHE A CD1 1 
ATOM   3961 C CD2 . PHE A 1 689 ? -19.249 55.323  60.553  1.00 97.87  ?  670 PHE A CD2 1 
ATOM   3962 C CE1 . PHE A 1 689 ? -16.864 53.949  60.695  1.00 101.74 ?  670 PHE A CE1 1 
ATOM   3963 C CE2 . PHE A 1 689 ? -18.109 55.954  60.988  1.00 101.51 ?  670 PHE A CE2 1 
ATOM   3964 C CZ  . PHE A 1 689 ? -16.912 55.263  61.060  1.00 99.86  ?  670 PHE A CZ  1 
ATOM   3965 N N   . TRP A 1 690 ? -19.959 51.062  62.434  1.00 90.07  ?  671 TRP A N   1 
ATOM   3966 C CA  . TRP A 1 690 ? -19.018 50.113  62.992  1.00 92.52  ?  671 TRP A CA  1 
ATOM   3967 C C   . TRP A 1 690 ? -19.795 48.979  63.629  1.00 89.59  ?  671 TRP A C   1 
ATOM   3968 O O   . TRP A 1 690 ? -21.021 48.991  63.681  1.00 88.79  ?  671 TRP A O   1 
ATOM   3969 C CB  . TRP A 1 690 ? -18.115 50.798  64.025  1.00 101.18 ?  671 TRP A CB  1 
ATOM   3970 C CG  . TRP A 1 690 ? -18.886 51.535  65.130  1.00 96.49  ?  671 TRP A CG  1 
ATOM   3971 C CD1 . TRP A 1 690 ? -19.381 50.993  66.289  1.00 98.32  ?  671 TRP A CD1 1 
ATOM   3972 C CD2 . TRP A 1 690 ? -19.224 52.931  65.169  1.00 93.62  ?  671 TRP A CD2 1 
ATOM   3973 N NE1 . TRP A 1 690 ? -20.015 51.961  67.035  1.00 99.06  ?  671 TRP A NE1 1 
ATOM   3974 C CE2 . TRP A 1 690 ? -19.929 53.158  66.375  1.00 96.17  ?  671 TRP A CE2 1 
ATOM   3975 C CE3 . TRP A 1 690 ? -19.002 54.012  64.301  1.00 97.27  ?  671 TRP A CE3 1 
ATOM   3976 C CZ2 . TRP A 1 690 ? -20.413 54.412  66.731  1.00 98.38  ?  671 TRP A CZ2 1 
ATOM   3977 C CZ3 . TRP A 1 690 ? -19.481 55.262  64.656  1.00 94.86  ?  671 TRP A CZ3 1 
ATOM   3978 C CH2 . TRP A 1 690 ? -20.182 55.449  65.860  1.00 98.00  ?  671 TRP A CH2 1 
ATOM   3979 N N   . ASP A 1 691 ? -19.078 48.018  64.152  1.00 88.30  ?  672 ASP A N   1 
ATOM   3980 C CA  . ASP A 1 691 ? -19.769 46.953  64.849  1.00 94.12  ?  672 ASP A CA  1 
ATOM   3981 C C   . ASP A 1 691 ? -20.264 47.434  66.211  1.00 102.67 ?  672 ASP A C   1 
ATOM   3982 O O   . ASP A 1 691 ? -19.441 47.643  67.116  1.00 104.78 ?  672 ASP A O   1 
ATOM   3983 C CB  . ASP A 1 691 ? -18.829 45.766  64.998  1.00 102.73 ?  672 ASP A CB  1 
ATOM   3984 C CG  . ASP A 1 691 ? -19.551 44.507  65.401  1.00 106.66 ?  672 ASP A CG  1 
ATOM   3985 O OD1 . ASP A 1 691 ? -18.933 43.415  65.344  1.00 109.43 ?  672 ASP A OD1 1 
ATOM   3986 O OD2 . ASP A 1 691 ? -20.741 44.620  65.774  1.00 103.40 ?  672 ASP A OD2 1 
ATOM   3987 N N   . PRO A 1 692 ? -21.578 47.603  66.416  1.00 102.79 ?  673 PRO A N   1 
ATOM   3988 C CA  . PRO A 1 692 ? -22.077 48.114  67.709  1.00 102.72 ?  673 PRO A CA  1 
ATOM   3989 C C   . PRO A 1 692 ? -21.877 47.167  68.870  1.00 101.08 ?  673 PRO A C   1 
ATOM   3990 O O   . PRO A 1 692 ? -22.146 47.551  70.018  1.00 103.18 ?  673 PRO A O   1 
ATOM   3991 C CB  . PRO A 1 692 ? -23.576 48.331  67.451  1.00 97.78  ?  673 PRO A CB  1 
ATOM   3992 C CG  . PRO A 1 692 ? -23.715 48.339  65.968  1.00 100.58 ?  673 PRO A CG  1 
ATOM   3993 C CD  . PRO A 1 692 ? -22.674 47.390  65.467  1.00 101.53 ?  673 PRO A CD  1 
ATOM   3994 N N   . SER A 1 693 ? -21.427 45.948  68.611  1.00 104.15 ?  674 SER A N   1 
ATOM   3995 C CA  . SER A 1 693 ? -21.287 44.927  69.636  1.00 111.14 ?  674 SER A CA  1 
ATOM   3996 C C   . SER A 1 693 ? -19.868 44.820  70.171  1.00 110.12 ?  674 SER A C   1 
ATOM   3997 O O   . SER A 1 693 ? -19.631 44.062  71.125  1.00 108.18 ?  674 SER A O   1 
ATOM   3998 C CB  . SER A 1 693 ? -21.733 43.564  69.083  1.00 108.57 ?  674 SER A CB  1 
ATOM   3999 O OG  . SER A 1 693 ? -21.054 43.261  67.873  1.00 100.79 ?  674 SER A OG  1 
ATOM   4000 N N   . VAL A 1 694 ? -18.921 45.532  69.566  1.00 104.48 ?  675 VAL A N   1 
ATOM   4001 C CA  . VAL A 1 694 ? -17.571 45.655  70.093  1.00 103.81 ?  675 VAL A CA  1 
ATOM   4002 C C   . VAL A 1 694 ? -17.416 47.068  70.636  1.00 102.58 ?  675 VAL A C   1 
ATOM   4003 O O   . VAL A 1 694 ? -17.711 48.054  69.942  1.00 103.46 ?  675 VAL A O   1 
ATOM   4004 C CB  . VAL A 1 694 ? -16.504 45.321  69.034  1.00 100.32 ?  675 VAL A CB  1 
ATOM   4005 C CG1 . VAL A 1 694 ? -16.581 43.857  68.687  1.00 103.10 ?  675 VAL A CG1 1 
ATOM   4006 C CG2 . VAL A 1 694 ? -16.659 46.180  67.784  1.00 100.76 ?  675 VAL A CG2 1 
ATOM   4007 N N   . ASN A 1 695 ? -17.005 47.164  71.897  1.00 101.24 ?  676 ASN A N   1 
ATOM   4008 C CA  . ASN A 1 695 ? -16.750 48.477  72.465  1.00 100.95 ?  676 ASN A CA  1 
ATOM   4009 C C   . ASN A 1 695 ? -15.477 49.079  71.888  1.00 101.08 ?  676 ASN A C   1 
ATOM   4010 O O   . ASN A 1 695 ? -15.373 50.307  71.763  1.00 102.55 ?  676 ASN A O   1 
ATOM   4011 C CB  . ASN A 1 695 ? -16.674 48.378  73.988  1.00 91.44  ?  676 ASN A CB  1 
ATOM   4012 C CG  . ASN A 1 695 ? -18.013 48.036  74.612  1.00 96.96  ?  676 ASN A CG  1 
ATOM   4013 O OD1 . ASN A 1 695 ? -18.101 47.187  75.501  1.00 92.93  ?  676 ASN A OD1 1 
ATOM   4014 N ND2 . ASN A 1 695 ? -19.068 48.702  74.148  1.00 99.83  ?  676 ASN A ND2 1 
ATOM   4015 N N   . LEU A 1 696 ? -14.530 48.239  71.476  1.00 93.38  ?  677 LEU A N   1 
ATOM   4016 C CA  . LEU A 1 696 ? -13.193 48.730  71.188  1.00 94.02  ?  677 LEU A CA  1 
ATOM   4017 C C   . LEU A 1 696 ? -12.487 47.852  70.164  1.00 91.36  ?  677 LEU A C   1 
ATOM   4018 O O   . LEU A 1 696 ? -12.641 46.633  70.169  1.00 96.63  ?  677 LEU A O   1 
ATOM   4019 C CB  . LEU A 1 696 ? -12.401 48.851  72.499  1.00 96.12  ?  677 LEU A CB  1 
ATOM   4020 C CG  . LEU A 1 696 ? -11.981 47.644  73.334  1.00 92.43  ?  677 LEU A CG  1 
ATOM   4021 C CD1 . LEU A 1 696 ? -10.925 48.051  74.327  1.00 87.19  ?  677 LEU A CD1 1 
ATOM   4022 C CD2 . LEU A 1 696 ? -13.172 47.118  74.083  1.00 98.09  ?  677 LEU A CD2 1 
ATOM   4023 N N   . PHE A 1 697 ? -11.724 48.489  69.275  1.00 84.69  ?  678 PHE A N   1 
ATOM   4024 C CA  . PHE A 1 697 ? -10.990 47.775  68.246  1.00 81.82  ?  678 PHE A CA  1 
ATOM   4025 C C   . PHE A 1 697 ? -9.721  48.534  67.889  1.00 81.14  ?  678 PHE A C   1 
ATOM   4026 O O   . PHE A 1 697 ? -9.653  49.756  68.024  1.00 85.71  ?  678 PHE A O   1 
ATOM   4027 C CB  . PHE A 1 697 ? -11.849 47.569  67.010  1.00 82.62  ?  678 PHE A CB  1 
ATOM   4028 C CG  . PHE A 1 697 ? -12.203 48.831  66.287  1.00 76.25  ?  678 PHE A CG  1 
ATOM   4029 C CD1 . PHE A 1 697 ? -13.469 49.390  66.433  1.00 74.98  ?  678 PHE A CD1 1 
ATOM   4030 C CD2 . PHE A 1 697 ? -11.298 49.430  65.408  1.00 73.47  ?  678 PHE A CD2 1 
ATOM   4031 C CE1 . PHE A 1 697 ? -13.822 50.545  65.731  1.00 80.71  ?  678 PHE A CE1 1 
ATOM   4032 C CE2 . PHE A 1 697 ? -11.632 50.588  64.704  1.00 74.91  ?  678 PHE A CE2 1 
ATOM   4033 C CZ  . PHE A 1 697 ? -12.896 51.151  64.862  1.00 78.80  ?  678 PHE A CZ  1 
ATOM   4034 N N   . GLY A 1 698 ? -8.722  47.805  67.399  1.00 81.90  ?  679 GLY A N   1 
ATOM   4035 C CA  . GLY A 1 698 ? -7.383  48.328  67.261  1.00 83.69  ?  679 GLY A CA  1 
ATOM   4036 C C   . GLY A 1 698 ? -7.001  48.610  65.820  1.00 79.15  ?  679 GLY A C   1 
ATOM   4037 O O   . GLY A 1 698 ? -7.722  48.280  64.893  1.00 85.10  ?  679 GLY A O   1 
ATOM   4038 N N   . HIS A 1 699 ? -5.846  49.260  65.659  1.00 78.38  ?  680 HIS A N   1 
ATOM   4039 C CA  . HIS A 1 699 ? -5.245  49.519  64.356  1.00 75.45  ?  680 HIS A CA  1 
ATOM   4040 C C   . HIS A 1 699 ? -3.745  49.405  64.510  1.00 82.80  ?  680 HIS A C   1 
ATOM   4041 O O   . HIS A 1 699 ? -3.152  50.106  65.336  1.00 84.10  ?  680 HIS A O   1 
ATOM   4042 C CB  . HIS A 1 699 ? -5.578  50.894  63.806  1.00 74.12  ?  680 HIS A CB  1 
ATOM   4043 C CG  . HIS A 1 699 ? -4.555  51.404  62.837  1.00 84.52  ?  680 HIS A CG  1 
ATOM   4044 N ND1 . HIS A 1 699 ? -3.564  52.290  63.195  1.00 90.52  ?  680 HIS A ND1 1 
ATOM   4045 C CD2 . HIS A 1 699 ? -4.353  51.135  61.525  1.00 87.13  ?  680 HIS A CD2 1 
ATOM   4046 C CE1 . HIS A 1 699 ? -2.814  52.569  62.143  1.00 89.32  ?  680 HIS A CE1 1 
ATOM   4047 N NE2 . HIS A 1 699 ? -3.270  51.877  61.118  1.00 86.64  ?  680 HIS A NE2 1 
ATOM   4048 N N   . VAL A 1 700 ? -3.141  48.562  63.715  1.00 83.77  ?  681 VAL A N   1 
ATOM   4049 C CA  . VAL A 1 700 ? -1.736  48.240  63.886  1.00 83.65  ?  681 VAL A CA  1 
ATOM   4050 C C   . VAL A 1 700 ? -0.906  49.201  63.053  1.00 84.67  ?  681 VAL A C   1 
ATOM   4051 O O   . VAL A 1 700 ? -1.246  49.507  61.912  1.00 87.06  ?  681 VAL A O   1 
ATOM   4052 C CB  . VAL A 1 700 ? -1.492  46.768  63.529  1.00 82.16  ?  681 VAL A CB  1 
ATOM   4053 C CG1 . VAL A 1 700 ? -0.089  46.334  63.893  1.00 78.97  ?  681 VAL A CG1 1 
ATOM   4054 C CG2 . VAL A 1 700 ? -2.498  45.925  64.282  1.00 84.36  ?  681 VAL A CG2 1 
ATOM   4055 N N   . GLY A 1 701 ? 0.153   49.735  63.653  1.00 89.98  ?  682 GLY A N   1 
ATOM   4056 C CA  . GLY A 1 701 ? 0.950   50.734  62.978  1.00 90.10  ?  682 GLY A CA  1 
ATOM   4057 C C   . GLY A 1 701 ? 1.935   50.107  62.012  1.00 97.71  ?  682 GLY A C   1 
ATOM   4058 O O   . GLY A 1 701 ? 2.384   48.974  62.187  1.00 99.36  ?  682 GLY A O   1 
ATOM   4059 N N   . SER A 1 702 ? 2.268   50.868  60.966  1.00 99.22  ?  683 SER A N   1 
ATOM   4060 C CA  . SER A 1 702 ? 3.232   50.397  59.977  1.00 102.06 ?  683 SER A CA  1 
ATOM   4061 C C   . SER A 1 702 ? 4.645   50.339  60.540  1.00 102.32 ?  683 SER A C   1 
ATOM   4062 O O   . SER A 1 702 ? 5.509   49.662  59.977  1.00 107.13 ?  683 SER A O   1 
ATOM   4063 C CB  . SER A 1 702 ? 3.205   51.304  58.747  1.00 98.46  ?  683 SER A CB  1 
ATOM   4064 O OG  . SER A 1 702 ? 3.223   52.666  59.148  1.00 110.10 ?  683 SER A OG  1 
ATOM   4065 N N   . THR A 1 703 ? 4.897   51.023  61.642  1.00 97.52  ?  684 THR A N   1 
ATOM   4066 C CA  . THR A 1 703 ? 6.236   51.125  62.182  1.00 98.70  ?  684 THR A CA  1 
ATOM   4067 C C   . THR A 1 703 ? 6.180   51.204  63.699  1.00 93.85  ?  684 THR A C   1 
ATOM   4068 O O   . THR A 1 703 ? 5.140   51.515  64.281  1.00 91.78  ?  684 THR A O   1 
ATOM   4069 C CB  . THR A 1 703 ? 6.969   52.325  61.567  1.00 102.70 ?  684 THR A CB  1 
ATOM   4070 O OG1 . THR A 1 703 ? 8.251   52.486  62.195  1.00 108.78 ?  684 THR A OG1 1 
ATOM   4071 C CG2 . THR A 1 703 ? 6.129   53.587  61.624  1.00 96.83  ?  684 THR A CG2 1 
ATOM   4072 N N   . THR A 1 704 ? 7.314   50.857  64.326  1.00 89.29  ?  685 THR A N   1 
ATOM   4073 C CA  . THR A 1 704 ? 7.459   50.966  65.776  1.00 84.33  ?  685 THR A CA  1 
ATOM   4074 C C   . THR A 1 704 ? 7.252   52.403  66.248  1.00 87.85  ?  685 THR A C   1 
ATOM   4075 O O   . THR A 1 704 ? 6.440   52.665  67.147  1.00 82.21  ?  685 THR A O   1 
ATOM   4076 C CB  . THR A 1 704 ? 8.844   50.463  66.200  1.00 85.64  ?  685 THR A CB  1 
ATOM   4077 O OG1 . THR A 1 704 ? 8.935   49.046  66.012  1.00 87.34  ?  685 THR A OG1 1 
ATOM   4078 C CG2 . THR A 1 704 ? 9.128   50.792  67.642  1.00 77.93  ?  685 THR A CG2 1 
ATOM   4079 N N   . ALA A 1 705 ? 7.970   53.353  65.640  1.00 90.84  ?  686 ALA A N   1 
ATOM   4080 C CA  . ALA A 1 705 ? 7.902   54.732  66.102  1.00 82.70  ?  686 ALA A CA  1 
ATOM   4081 C C   . ALA A 1 705 ? 6.473   55.258  66.132  1.00 81.41  ?  686 ALA A C   1 
ATOM   4082 O O   . ALA A 1 705 ? 6.143   56.064  67.005  1.00 92.86  ?  686 ALA A O   1 
ATOM   4083 C CB  . ALA A 1 705 ? 8.781   55.627  65.238  1.00 83.16  ?  686 ALA A CB  1 
ATOM   4084 N N   . SER A 1 706 ? 5.604   54.813  65.227  1.00 78.24  ?  687 SER A N   1 
ATOM   4085 C CA  . SER A 1 706 ? 4.229   55.298  65.227  1.00 81.80  ?  687 SER A CA  1 
ATOM   4086 C C   . SER A 1 706 ? 3.254   54.301  65.855  1.00 78.97  ?  687 SER A C   1 
ATOM   4087 O O   . SER A 1 706 ? 2.050   54.351  65.568  1.00 77.74  ?  687 SER A O   1 
ATOM   4088 C CB  . SER A 1 706 ? 3.778   55.666  63.806  1.00 88.02  ?  687 SER A CB  1 
ATOM   4089 O OG  . SER A 1 706 ? 3.679   54.529  62.955  1.00 95.56  ?  687 SER A OG  1 
ATOM   4090 N N   . ARG A 1 707 ? 3.736   53.411  66.727  1.00 74.19  ?  688 ARG A N   1 
ATOM   4091 C CA  . ARG A 1 707 ? 2.858   52.354  67.221  1.00 70.58  ?  688 ARG A CA  1 
ATOM   4092 C C   . ARG A 1 707 ? 1.683   52.908  68.020  1.00 75.91  ?  688 ARG A C   1 
ATOM   4093 O O   . ARG A 1 707 ? 0.583   52.355  67.954  1.00 78.32  ?  688 ARG A O   1 
ATOM   4094 C CB  . ARG A 1 707 ? 3.654   51.334  68.037  1.00 69.23  ?  688 ARG A CB  1 
ATOM   4095 C CG  . ARG A 1 707 ? 4.223   51.806  69.347  1.00 69.30  ?  688 ARG A CG  1 
ATOM   4096 C CD  . ARG A 1 707 ? 5.149   50.757  69.874  1.00 70.02  ?  688 ARG A CD  1 
ATOM   4097 N NE  . ARG A 1 707 ? 5.737   51.048  71.178  1.00 66.04  ?  688 ARG A NE  1 
ATOM   4098 C CZ  . ARG A 1 707 ? 6.758   50.360  71.682  1.00 67.64  ?  688 ARG A CZ  1 
ATOM   4099 N NH1 . ARG A 1 707 ? 7.290   49.354  71.008  1.00 78.87  ?  688 ARG A NH1 1 
ATOM   4100 N NH2 . ARG A 1 707 ? 7.257   50.657  72.856  1.00 70.22  ?  688 ARG A NH2 1 
ATOM   4101 N N   . GLY A 1 708 ? 1.874   54.011  68.748  1.00 79.96  ?  689 GLY A N   1 
ATOM   4102 C CA  . GLY A 1 708 ? 0.780   54.606  69.491  1.00 75.64  ?  689 GLY A CA  1 
ATOM   4103 C C   . GLY A 1 708 ? -0.092  55.594  68.735  1.00 80.55  ?  689 GLY A C   1 
ATOM   4104 O O   . GLY A 1 708 ? -1.120  56.022  69.276  1.00 77.27  ?  689 GLY A O   1 
ATOM   4105 N N   . GLU A 1 709 ? 0.283   55.965  67.503  1.00 81.22  ?  690 GLU A N   1 
ATOM   4106 C CA  . GLU A 1 709 ? -0.443  56.957  66.702  1.00 76.79  ?  690 GLU A CA  1 
ATOM   4107 C C   . GLU A 1 709 ? -1.774  56.377  66.234  1.00 78.34  ?  690 GLU A C   1 
ATOM   4108 O O   . GLU A 1 709 ? -1.829  55.528  65.342  1.00 83.30  ?  690 GLU A O   1 
ATOM   4109 C CB  . GLU A 1 709 ? 0.413   57.397  65.523  1.00 77.58  ?  690 GLU A CB  1 
ATOM   4110 C CG  . GLU A 1 709 ? -0.211  58.454  64.643  1.00 83.64  ?  690 GLU A CG  1 
ATOM   4111 C CD  . GLU A 1 709 ? 0.803   59.037  63.670  1.00 95.98  ?  690 GLU A CD  1 
ATOM   4112 O OE1 . GLU A 1 709 ? 1.958   59.297  64.094  1.00 99.26  ?  690 GLU A OE1 1 
ATOM   4113 O OE2 . GLU A 1 709 ? 0.450   59.219  62.480  1.00 101.52 ?  690 GLU A OE2 1 
ATOM   4114 N N   . LEU A 1 710 ? -2.855  56.811  66.866  1.00 75.21  ?  691 LEU A N   1 
ATOM   4115 C CA  . LEU A 1 710 ? -4.209  56.387  66.516  1.00 75.88  ?  691 LEU A CA  1 
ATOM   4116 C C   . LEU A 1 710 ? -4.387  54.863  66.535  1.00 74.48  ?  691 LEU A C   1 
ATOM   4117 O O   . LEU A 1 710 ? -5.022  54.281  65.659  1.00 77.88  ?  691 LEU A O   1 
ATOM   4118 C CB  . LEU A 1 710 ? -4.599  56.986  65.172  1.00 75.39  ?  691 LEU A CB  1 
ATOM   4119 C CG  . LEU A 1 710 ? -4.776  58.470  65.466  1.00 77.26  ?  691 LEU A CG  1 
ATOM   4120 C CD1 . LEU A 1 710 ? -4.828  59.293  64.198  1.00 78.34  ?  691 LEU A CD1 1 
ATOM   4121 C CD2 . LEU A 1 710 ? -6.021  58.674  66.339  1.00 70.91  ?  691 LEU A CD2 1 
ATOM   4122 N N   . PHE A 1 711 ? -3.899  54.226  67.597  1.00 73.44  ?  692 PHE A N   1 
ATOM   4123 C CA  . PHE A 1 711 ? -3.837  52.776  67.650  1.00 72.78  ?  692 PHE A CA  1 
ATOM   4124 C C   . PHE A 1 711 ? -5.097  52.115  68.189  1.00 80.23  ?  692 PHE A C   1 
ATOM   4125 O O   . PHE A 1 711 ? -5.174  50.880  68.159  1.00 80.50  ?  692 PHE A O   1 
ATOM   4126 C CB  . PHE A 1 711 ? -2.646  52.321  68.501  1.00 71.42  ?  692 PHE A CB  1 
ATOM   4127 C CG  . PHE A 1 711 ? -2.946  52.241  69.978  1.00 76.71  ?  692 PHE A CG  1 
ATOM   4128 C CD1 . PHE A 1 711 ? -3.126  53.392  70.736  1.00 82.02  ?  692 PHE A CD1 1 
ATOM   4129 C CD2 . PHE A 1 711 ? -3.060  51.017  70.616  1.00 76.88  ?  692 PHE A CD2 1 
ATOM   4130 C CE1 . PHE A 1 711 ? -3.405  53.316  72.107  1.00 77.36  ?  692 PHE A CE1 1 
ATOM   4131 C CE2 . PHE A 1 711 ? -3.339  50.938  71.991  1.00 79.32  ?  692 PHE A CE2 1 
ATOM   4132 C CZ  . PHE A 1 711 ? -3.510  52.082  72.729  1.00 75.01  ?  692 PHE A CZ  1 
ATOM   4133 N N   . LEU A 1 712 ? -6.082  52.866  68.685  1.00 77.70  ?  693 LEU A N   1 
ATOM   4134 C CA  . LEU A 1 712 ? -7.208  52.177  69.315  1.00 79.21  ?  693 LEU A CA  1 
ATOM   4135 C C   . LEU A 1 712 ? -8.453  53.054  69.252  1.00 79.18  ?  693 LEU A C   1 
ATOM   4136 O O   . LEU A 1 712 ? -8.354  54.282  69.228  1.00 79.35  ?  693 LEU A O   1 
ATOM   4137 C CB  . LEU A 1 712 ? -6.866  51.803  70.758  1.00 71.06  ?  693 LEU A CB  1 
ATOM   4138 C CG  . LEU A 1 712 ? -7.976  51.311  71.679  1.00 79.96  ?  693 LEU A CG  1 
ATOM   4139 C CD1 . LEU A 1 712 ? -8.760  50.156  71.086  1.00 79.71  ?  693 LEU A CD1 1 
ATOM   4140 C CD2 . LEU A 1 712 ? -7.396  50.925  73.041  1.00 83.44  ?  693 LEU A CD2 1 
ATOM   4141 N N   . PHE A 1 713 ? -9.626  52.412  69.198  1.00 77.14  ?  694 PHE A N   1 
ATOM   4142 C CA  . PHE A 1 713 ? -10.902 53.102  69.029  1.00 80.36  ?  694 PHE A CA  1 
ATOM   4143 C C   . PHE A 1 713 ? -11.917 52.607  70.065  1.00 87.71  ?  694 PHE A C   1 
ATOM   4144 O O   . PHE A 1 713 ? -11.868 51.443  70.485  1.00 83.76  ?  694 PHE A O   1 
ATOM   4145 C CB  . PHE A 1 713 ? -11.436 52.909  67.578  1.00 76.61  ?  694 PHE A CB  1 
ATOM   4146 C CG  . PHE A 1 713 ? -10.623 53.635  66.523  1.00 75.97  ?  694 PHE A CG  1 
ATOM   4147 C CD1 . PHE A 1 713 ? -9.386  53.145  66.107  1.00 76.64  ?  694 PHE A CD1 1 
ATOM   4148 C CD2 . PHE A 1 713 ? -11.081 54.827  65.970  1.00 75.11  ?  694 PHE A CD2 1 
ATOM   4149 C CE1 . PHE A 1 713 ? -8.614  53.830  65.149  1.00 75.98  ?  694 PHE A CE1 1 
ATOM   4150 C CE2 . PHE A 1 713 ? -10.319 55.517  65.009  1.00 77.76  ?  694 PHE A CE2 1 
ATOM   4151 C CZ  . PHE A 1 713 ? -9.085  55.019  64.600  1.00 74.75  ?  694 PHE A CZ  1 
ATOM   4152 N N   . TRP A 1 714 ? -12.839 53.498  70.494  1.00 86.84  ?  695 TRP A N   1 
ATOM   4153 C CA  . TRP A 1 714 ? -13.863 53.141  71.486  1.00 87.78  ?  695 TRP A CA  1 
ATOM   4154 C C   . TRP A 1 714 ? -15.264 53.536  71.012  1.00 91.67  ?  695 TRP A C   1 
ATOM   4155 O O   . TRP A 1 714 ? -15.472 54.657  70.526  1.00 89.31  ?  695 TRP A O   1 
ATOM   4156 C CB  . TRP A 1 714 ? -13.594 53.793  72.857  1.00 87.19  ?  695 TRP A CB  1 
ATOM   4157 C CG  . TRP A 1 714 ? -12.218 53.538  73.497  1.00 90.00  ?  695 TRP A CG  1 
ATOM   4158 C CD1 . TRP A 1 714 ? -10.999 53.943  73.016  1.00 89.61  ?  695 TRP A CD1 1 
ATOM   4159 C CD2 . TRP A 1 714 ? -11.944 52.898  74.763  1.00 85.62  ?  695 TRP A CD2 1 
ATOM   4160 N NE1 . TRP A 1 714 ? -9.989  53.556  73.874  1.00 84.50  ?  695 TRP A NE1 1 
ATOM   4161 C CE2 . TRP A 1 714 ? -10.542 52.916  74.951  1.00 84.42  ?  695 TRP A CE2 1 
ATOM   4162 C CE3 . TRP A 1 714 ? -12.741 52.299  75.739  1.00 86.51  ?  695 TRP A CE3 1 
ATOM   4163 C CZ2 . TRP A 1 714 ? -9.927  52.355  76.069  1.00 82.35  ?  695 TRP A CZ2 1 
ATOM   4164 C CZ3 . TRP A 1 714 ? -12.120 51.732  76.850  1.00 84.84  ?  695 TRP A CZ3 1 
ATOM   4165 C CH2 . TRP A 1 714 ? -10.730 51.769  77.002  1.00 80.73  ?  695 TRP A CH2 1 
ATOM   4166 N N   . ASN A 1 715 ? -16.219 52.607  71.156  1.00 90.29  ?  696 ASN A N   1 
ATOM   4167 C CA  . ASN A 1 715 ? -17.654 52.863  70.967  1.00 100.05 ?  696 ASN A CA  1 
ATOM   4168 C C   . ASN A 1 715 ? -18.303 52.685  72.333  1.00 102.03 ?  696 ASN A C   1 
ATOM   4169 O O   . ASN A 1 715 ? -18.823 51.616  72.661  1.00 100.66 ?  696 ASN A O   1 
ATOM   4170 C CB  . ASN A 1 715 ? -18.311 51.926  69.937  1.00 98.11  ?  696 ASN A CB  1 
ATOM   4171 C CG  . ASN A 1 715 ? -19.848 51.908  70.050  1.00 103.44 ?  696 ASN A CG  1 
ATOM   4172 O OD1 . ASN A 1 715 ? -20.493 52.934  70.346  1.00 111.55 ?  696 ASN A OD1 1 
ATOM   4173 N ND2 . ASN A 1 715 ? -20.432 50.728  69.848  1.00 93.84  ?  696 ASN A ND2 1 
ATOM   4174 N N   . LEU A 1 716 ? -18.278 53.743  73.133  1.00 108.59 ?  697 LEU A N   1 
ATOM   4175 C CA  . LEU A 1 716 ? -18.731 53.615  74.510  1.00 108.12 ?  697 LEU A CA  1 
ATOM   4176 C C   . LEU A 1 716 ? -20.114 54.178  74.724  1.00 108.54 ?  697 LEU A C   1 
ATOM   4177 O O   . LEU A 1 716 ? -20.759 53.837  75.724  1.00 106.08 ?  697 LEU A O   1 
ATOM   4178 C CB  . LEU A 1 716 ? -17.772 54.333  75.459  1.00 102.21 ?  697 LEU A CB  1 
ATOM   4179 C CG  . LEU A 1 716 ? -16.347 53.802  75.373  1.00 99.73  ?  697 LEU A CG  1 
ATOM   4180 C CD1 . LEU A 1 716 ? -15.443 54.632  76.266  1.00 95.24  ?  697 LEU A CD1 1 
ATOM   4181 C CD2 . LEU A 1 716 ? -16.294 52.298  75.696  1.00 87.32  ?  697 LEU A CD2 1 
ATOM   4182 N N   . TYR A 1 717 ? -20.575 55.009  73.798  1.00 110.36 ?  698 TYR A N   1 
ATOM   4183 C CA  . TYR A 1 717 ? -21.662 55.928  74.058  1.00 109.25 ?  698 TYR A CA  1 
ATOM   4184 C C   . TYR A 1 717 ? -22.905 55.548  73.263  1.00 118.30 ?  698 TYR A C   1 
ATOM   4185 O O   . TYR A 1 717 ? -22.857 54.761  72.298  1.00 120.38 ?  698 TYR A O   1 
ATOM   4186 C CB  . TYR A 1 717 ? -21.214 57.366  73.748  1.00 109.63 ?  698 TYR A CB  1 
ATOM   4187 C CG  . TYR A 1 717 ? -19.986 57.781  74.560  1.00 108.44 ?  698 TYR A CG  1 
ATOM   4188 C CD1 . TYR A 1 717 ? -18.740 57.941  73.954  1.00 103.05 ?  698 TYR A CD1 1 
ATOM   4189 C CD2 . TYR A 1 717 ? -20.072 57.977  75.948  1.00 104.82 ?  698 TYR A CD2 1 
ATOM   4190 C CE1 . TYR A 1 717 ? -17.621 58.306  74.705  1.00 98.25  ?  698 TYR A CE1 1 
ATOM   4191 C CE2 . TYR A 1 717 ? -18.955 58.330  76.706  1.00 94.78  ?  698 TYR A CE2 1 
ATOM   4192 C CZ  . TYR A 1 717 ? -17.735 58.493  76.078  1.00 94.12  ?  698 TYR A CZ  1 
ATOM   4193 O OH  . TYR A 1 717 ? -16.625 58.839  76.817  1.00 91.73  ?  698 TYR A OH  1 
ATOM   4194 N N   . LYS A 1 718 ? -24.031 56.100  73.733  1.00 117.00 ?  699 LYS A N   1 
ATOM   4195 C CA  . LYS A 1 718 ? -25.338 55.968  73.100  1.00 120.45 ?  699 LYS A CA  1 
ATOM   4196 C C   . LYS A 1 718 ? -25.265 56.507  71.680  1.00 116.00 ?  699 LYS A C   1 
ATOM   4197 O O   . LYS A 1 718 ? -25.385 55.745  70.710  1.00 121.16 ?  699 LYS A O   1 
ATOM   4198 C CB  . LYS A 1 718 ? -26.410 56.703  73.923  1.00 115.42 ?  699 LYS A CB  1 
ATOM   4199 C CG  . LYS A 1 718 ? -26.442 56.292  75.407  1.00 118.91 ?  699 LYS A CG  1 
ATOM   4200 C CD  . LYS A 1 718 ? -27.181 57.293  76.306  1.00 118.88 ?  699 LYS A CD  1 
ATOM   4201 C CE  . LYS A 1 718 ? -27.061 56.909  77.788  1.00 122.45 ?  699 LYS A CE  1 
ATOM   4202 N NZ  . LYS A 1 718 ? -27.346 58.038  78.736  1.00 114.33 ?  699 LYS A NZ  1 
ATOM   4203 N N   . ALA A 1 719 ? -25.023 57.810  71.560  1.00 100.51 ?  700 ALA A N   1 
ATOM   4204 C CA  . ALA A 1 719 ? -24.872 58.479  70.276  1.00 103.17 ?  700 ALA A CA  1 
ATOM   4205 C C   . ALA A 1 719 ? -23.756 57.849  69.435  1.00 105.21 ?  700 ALA A C   1 
ATOM   4206 O O   . ALA A 1 719 ? -22.958 57.039  69.934  1.00 106.97 ?  700 ALA A O   1 
ATOM   4207 C CB  . ALA A 1 719 ? -24.621 59.975  70.500  1.00 96.68  ?  700 ALA A CB  1 
ATOM   4208 N N   . PRO A 1 720 ? -23.699 58.158  68.139  1.00 103.52 ?  701 PRO A N   1 
ATOM   4209 C CA  . PRO A 1 720 ? -22.606 57.668  67.271  1.00 101.25 ?  701 PRO A CA  1 
ATOM   4210 C C   . PRO A 1 720 ? -21.283 58.399  67.456  1.00 99.24  ?  701 PRO A C   1 
ATOM   4211 O O   . PRO A 1 720 ? -20.917 59.318  66.707  1.00 96.91  ?  701 PRO A O   1 
ATOM   4212 C CB  . PRO A 1 720 ? -23.163 57.907  65.868  1.00 104.36 ?  701 PRO A CB  1 
ATOM   4213 C CG  . PRO A 1 720 ? -24.129 59.011  66.037  1.00 107.33 ?  701 PRO A CG  1 
ATOM   4214 C CD  . PRO A 1 720 ? -24.772 58.793  67.354  1.00 108.49 ?  701 PRO A CD  1 
ATOM   4215 N N   . ILE A 1 721 ? -20.533 57.972  68.470  1.00 97.45  ?  702 ILE A N   1 
ATOM   4216 C CA  . ILE A 1 721 ? -19.243 58.572  68.782  1.00 94.77  ?  702 ILE A CA  1 
ATOM   4217 C C   . ILE A 1 721 ? -18.213 57.465  68.859  1.00 89.56  ?  702 ILE A C   1 
ATOM   4218 O O   . ILE A 1 721 ? -18.348 56.527  69.659  1.00 94.72  ?  702 ILE A O   1 
ATOM   4219 C CB  . ILE A 1 721 ? -19.255 59.386  70.090  1.00 96.90  ?  702 ILE A CB  1 
ATOM   4220 C CG1 . ILE A 1 721 ? -20.238 60.561  69.994  1.00 97.50  ?  702 ILE A CG1 1 
ATOM   4221 C CG2 . ILE A 1 721 ? -17.844 59.896  70.378  1.00 89.60  ?  702 ILE A CG2 1 
ATOM   4222 C CD1 . ILE A 1 721 ? -20.953 60.907  71.310  1.00 94.78  ?  702 ILE A CD1 1 
ATOM   4223 N N   . LEU A 1 722 ? -17.221 57.557  67.995  1.00 87.66  ?  703 LEU A N   1 
ATOM   4224 C CA  . LEU A 1 722 ? -15.958 56.873  68.165  1.00 93.82  ?  703 LEU A CA  1 
ATOM   4225 C C   . LEU A 1 722 ? -14.935 57.816  68.764  1.00 94.57  ?  703 LEU A C   1 
ATOM   4226 O O   . LEU A 1 722 ? -14.922 59.020  68.484  1.00 92.98  ?  703 LEU A O   1 
ATOM   4227 C CB  . LEU A 1 722 ? -15.409 56.295  66.860  1.00 95.19  ?  703 LEU A CB  1 
ATOM   4228 C CG  . LEU A 1 722 ? -16.098 55.048  66.319  1.00 95.96  ?  703 LEU A CG  1 
ATOM   4229 C CD1 . LEU A 1 722 ? -15.510 54.659  64.974  1.00 96.07  ?  703 LEU A CD1 1 
ATOM   4230 C CD2 . LEU A 1 722 ? -15.946 53.920  67.345  1.00 90.55  ?  703 LEU A CD2 1 
ATOM   4231 N N   . LEU A 1 723 ? -14.044 57.224  69.541  1.00 87.16  ?  704 LEU A N   1 
ATOM   4232 C CA  . LEU A 1 723 ? -13.059 57.915  70.339  1.00 81.10  ?  704 LEU A CA  1 
ATOM   4233 C C   . LEU A 1 723 ? -11.747 57.189  70.077  1.00 83.50  ?  704 LEU A C   1 
ATOM   4234 O O   . LEU A 1 723 ? -11.730 55.955  70.031  1.00 87.84  ?  704 LEU A O   1 
ATOM   4235 C CB  . LEU A 1 723 ? -13.521 57.846  71.785  1.00 84.36  ?  704 LEU A CB  1 
ATOM   4236 C CG  . LEU A 1 723 ? -13.115 58.865  72.817  1.00 88.46  ?  704 LEU A CG  1 
ATOM   4237 C CD1 . LEU A 1 723 ? -14.186 58.869  73.885  1.00 88.93  ?  704 LEU A CD1 1 
ATOM   4238 C CD2 . LEU A 1 723 ? -11.808 58.413  73.390  1.00 91.51  ?  704 LEU A CD2 1 
ATOM   4239 N N   . ALA A 1 724 ? -10.668 57.934  69.849  1.00 80.09  ?  705 ALA A N   1 
ATOM   4240 C CA  . ALA A 1 724 ? -9.438  57.382  69.279  1.00 78.01  ?  705 ALA A CA  1 
ATOM   4241 C C   . ALA A 1 724 ? -8.208  57.808  70.077  1.00 78.59  ?  705 ALA A C   1 
ATOM   4242 O O   . ALA A 1 724 ? -7.952  59.007  70.234  1.00 81.02  ?  705 ALA A O   1 
ATOM   4243 C CB  . ALA A 1 724 ? -9.263  57.833  67.821  1.00 76.43  ?  705 ALA A CB  1 
ATOM   4244 N N   . LEU A 1 725 ? -7.406  56.839  70.505  1.00 70.17  ?  706 LEU A N   1 
ATOM   4245 C CA  . LEU A 1 725 ? -6.297  57.081  71.416  1.00 70.17  ?  706 LEU A CA  1 
ATOM   4246 C C   . LEU A 1 725 ? -4.987  57.392  70.700  1.00 72.36  ?  706 LEU A C   1 
ATOM   4247 O O   . LEU A 1 725 ? -4.685  56.836  69.648  1.00 73.62  ?  706 LEU A O   1 
ATOM   4248 C CB  . LEU A 1 725 ? -6.103  55.865  72.313  1.00 71.36  ?  706 LEU A CB  1 
ATOM   4249 C CG  . LEU A 1 725 ? -7.227  55.684  73.341  1.00 84.06  ?  706 LEU A CG  1 
ATOM   4250 C CD1 . LEU A 1 725 ? -6.785  54.833  74.553  1.00 79.44  ?  706 LEU A CD1 1 
ATOM   4251 C CD2 . LEU A 1 725 ? -7.751  57.055  73.809  1.00 77.33  ?  706 LEU A CD2 1 
ATOM   4252 N N   . VAL A 1 726 ? -4.195  58.278  71.302  1.00 76.21  ?  707 VAL A N   1 
ATOM   4253 C CA  . VAL A 1 726 ? -2.818  58.557  70.890  1.00 71.79  ?  707 VAL A CA  1 
ATOM   4254 C C   . VAL A 1 726 ? -1.925  58.306  72.098  1.00 74.13  ?  707 VAL A C   1 
ATOM   4255 O O   . VAL A 1 726 ? -1.964  59.072  73.069  1.00 80.32  ?  707 VAL A O   1 
ATOM   4256 C CB  . VAL A 1 726 ? -2.648  59.993  70.385  1.00 66.93  ?  707 VAL A CB  1 
ATOM   4257 C CG1 . VAL A 1 726 ? -1.271  60.180  69.766  1.00 69.59  ?  707 VAL A CG1 1 
ATOM   4258 C CG2 . VAL A 1 726 ? -3.737  60.332  69.408  1.00 65.87  ?  707 VAL A CG2 1 
ATOM   4259 N N   . ALA A 1 727 ? -1.118  57.254  72.048  1.00 70.66  ?  708 ALA A N   1 
ATOM   4260 C CA  . ALA A 1 727 ? -0.318  56.839  73.196  1.00 72.08  ?  708 ALA A CA  1 
ATOM   4261 C C   . ALA A 1 727 ? 1.170   56.935  72.872  1.00 67.37  ?  708 ALA A C   1 
ATOM   4262 O O   . ALA A 1 727 ? 1.560   57.235  71.752  1.00 71.99  ?  708 ALA A O   1 
ATOM   4263 C CB  . ALA A 1 727 ? -0.693  55.417  73.621  1.00 76.95  ?  708 ALA A CB  1 
ATOM   4264 N N   . GLY A 1 728 ? 2.004   56.685  73.877  1.00 66.41  ?  709 GLY A N   1 
ATOM   4265 C CA  . GLY A 1 728 ? 3.437   56.517  73.695  1.00 65.39  ?  709 GLY A CA  1 
ATOM   4266 C C   . GLY A 1 728 ? 4.109   57.757  73.138  1.00 69.63  ?  709 GLY A C   1 
ATOM   4267 O O   . GLY A 1 728 ? 3.651   58.888  73.338  1.00 76.40  ?  709 GLY A O   1 
ATOM   4268 N N   . GLU A 1 729 ? 5.216   57.545  72.413  1.00 69.72  ?  710 GLU A N   1 
ATOM   4269 C CA  . GLU A 1 729 ? 5.933   58.674  71.829  1.00 65.88  ?  710 GLU A CA  1 
ATOM   4270 C C   . GLU A 1 729 ? 5.070   59.453  70.845  1.00 70.26  ?  710 GLU A C   1 
ATOM   4271 O O   . GLU A 1 729 ? 5.359   60.626  70.579  1.00 74.19  ?  710 GLU A O   1 
ATOM   4272 C CB  . GLU A 1 729 ? 7.223   58.211  71.152  1.00 62.14  ?  710 GLU A CB  1 
ATOM   4273 C CG  . GLU A 1 729 ? 8.128   57.373  72.039  1.00 64.81  ?  710 GLU A CG  1 
ATOM   4274 C CD  . GLU A 1 729 ? 9.114   58.209  72.842  1.00 76.51  ?  710 GLU A CD  1 
ATOM   4275 O OE1 . GLU A 1 729 ? 8.777   59.368  73.164  1.00 78.49  ?  710 GLU A OE1 1 
ATOM   4276 O OE2 . GLU A 1 729 ? 10.223  57.717  73.168  1.00 81.41  ?  710 GLU A OE2 1 
ATOM   4277 N N   . ALA A 1 730 ? 3.995   58.850  70.337  1.00 67.65  ?  711 ALA A N   1 
ATOM   4278 C CA  . ALA A 1 730 ? 3.099   59.557  69.424  1.00 71.15  ?  711 ALA A CA  1 
ATOM   4279 C C   . ALA A 1 730 ? 2.370   60.706  70.119  1.00 76.45  ?  711 ALA A C   1 
ATOM   4280 O O   . ALA A 1 730 ? 2.122   61.754  69.505  1.00 78.36  ?  711 ALA A O   1 
ATOM   4281 C CB  . ALA A 1 730 ? 2.091   58.577  68.820  1.00 73.39  ?  711 ALA A CB  1 
ATOM   4282 N N   . ALA A 1 731 ? 2.014   60.524  71.396  1.00 77.31  ?  712 ALA A N   1 
ATOM   4283 C CA  . ALA A 1 731 ? 1.175   61.495  72.098  1.00 76.07  ?  712 ALA A CA  1 
ATOM   4284 C C   . ALA A 1 731 ? 1.798   62.883  72.078  1.00 77.94  ?  712 ALA A C   1 
ATOM   4285 O O   . ALA A 1 731 ? 1.138   63.870  71.723  1.00 74.51  ?  712 ALA A O   1 
ATOM   4286 C CB  . ALA A 1 731 ? 0.946   61.038  73.538  1.00 70.46  ?  712 ALA A CB  1 
ATOM   4287 N N   . GLY A 1 732 ? 3.081   62.968  72.453  1.00 76.60  ?  713 GLY A N   1 
ATOM   4288 C CA  . GLY A 1 732 ? 3.741   64.257  72.535  1.00 77.38  ?  713 GLY A CA  1 
ATOM   4289 C C   . GLY A 1 732 ? 3.922   64.922  71.195  1.00 74.56  ?  713 GLY A C   1 
ATOM   4290 O O   . GLY A 1 732 ? 3.876   66.149  71.099  1.00 81.22  ?  713 GLY A O   1 
ATOM   4291 N N   . ILE A 1 733 ? 4.105   64.125  70.145  1.00 81.08  ?  714 ILE A N   1 
ATOM   4292 C CA  . ILE A 1 733 ? 4.348   64.630  68.799  1.00 77.27  ?  714 ILE A CA  1 
ATOM   4293 C C   . ILE A 1 733 ? 3.050   65.083  68.141  1.00 79.60  ?  714 ILE A C   1 
ATOM   4294 O O   . ILE A 1 733 ? 3.008   66.123  67.479  1.00 77.91  ?  714 ILE A O   1 
ATOM   4295 C CB  . ILE A 1 733 ? 5.056   63.541  67.981  1.00 73.41  ?  714 ILE A CB  1 
ATOM   4296 C CG1 . ILE A 1 733 ? 6.535   63.495  68.370  1.00 76.29  ?  714 ILE A CG1 1 
ATOM   4297 C CG2 . ILE A 1 733 ? 4.890   63.816  66.506  1.00 74.77  ?  714 ILE A CG2 1 
ATOM   4298 C CD1 . ILE A 1 733 ? 7.248   62.212  67.992  1.00 74.10  ?  714 ILE A CD1 1 
ATOM   4299 N N   . MET A 1 734 ? 1.963   64.333  68.330  1.00 80.14  ?  715 MET A N   1 
ATOM   4300 C CA  . MET A 1 734 ? 0.710   64.697  67.683  1.00 78.70  ?  715 MET A CA  1 
ATOM   4301 C C   . MET A 1 734 ? 0.117   65.990  68.205  1.00 82.93  ?  715 MET A C   1 
ATOM   4302 O O   . MET A 1 734 ? -0.954  66.399  67.738  1.00 88.98  ?  715 MET A O   1 
ATOM   4303 C CB  . MET A 1 734 ? -0.304  63.577  67.846  1.00 81.10  ?  715 MET A CB  1 
ATOM   4304 C CG  . MET A 1 734 ? 0.054   62.319  67.064  1.00 91.80  ?  715 MET A CG  1 
ATOM   4305 S SD  . MET A 1 734 ? -0.513  62.354  65.354  1.00 108.47 ?  715 MET A SD  1 
ATOM   4306 C CE  . MET A 1 734 ? 0.964   62.923  64.508  1.00 93.39  ?  715 MET A CE  1 
ATOM   4307 N N   . GLU A 1 735 ? 0.760   66.655  69.156  1.00 84.96  ?  716 GLU A N   1 
ATOM   4308 C CA  . GLU A 1 735 ? 0.205   67.905  69.642  1.00 84.20  ?  716 GLU A CA  1 
ATOM   4309 C C   . GLU A 1 735 ? 0.656   69.098  68.810  1.00 81.01  ?  716 GLU A C   1 
ATOM   4310 O O   . GLU A 1 735 ? 0.047   70.165  68.901  1.00 80.63  ?  716 GLU A O   1 
ATOM   4311 C CB  . GLU A 1 735 ? 0.572   68.104  71.113  1.00 79.09  ?  716 GLU A CB  1 
ATOM   4312 C CG  . GLU A 1 735 ? -0.330  67.318  72.056  1.00 79.91  ?  716 GLU A CG  1 
ATOM   4313 C CD  . GLU A 1 735 ? -0.015  67.565  73.534  1.00 82.65  ?  716 GLU A CD  1 
ATOM   4314 O OE1 . GLU A 1 735 ? 0.649   68.606  73.815  1.00 82.28  ?  716 GLU A OE1 1 
ATOM   4315 O OE2 . GLU A 1 735 ? -0.435  66.737  74.399  1.00 70.08  ?  716 GLU A OE2 1 
ATOM   4316 N N   . ASN A 1 736 ? 1.692   68.931  67.996  1.00 80.28  ?  717 ASN A N   1 
ATOM   4317 C CA  . ASN A 1 736 ? 2.117   69.924  67.024  1.00 82.07  ?  717 ASN A CA  1 
ATOM   4318 C C   . ASN A 1 736 ? 1.465   69.736  65.663  1.00 85.51  ?  717 ASN A C   1 
ATOM   4319 O O   . ASN A 1 736 ? 1.896   70.360  64.691  1.00 90.89  ?  717 ASN A O   1 
ATOM   4320 C CB  . ASN A 1 736 ? 3.630   69.883  66.864  1.00 86.20  ?  717 ASN A CB  1 
ATOM   4321 C CG  . ASN A 1 736 ? 4.347   70.265  68.128  1.00 94.93  ?  717 ASN A CG  1 
ATOM   4322 O OD1 . ASN A 1 736 ? 3.746   70.823  69.058  1.00 92.57  ?  717 ASN A OD1 1 
ATOM   4323 N ND2 . ASN A 1 736 ? 5.638   69.949  68.189  1.00 101.23 ?  717 ASN A ND2 1 
ATOM   4324 N N   . ILE A 1 737 ? 0.449   68.888  65.566  1.00 85.61  ?  718 ILE A N   1 
ATOM   4325 C CA  . ILE A 1 737 ? -0.256  68.627  64.318  1.00 90.11  ?  718 ILE A CA  1 
ATOM   4326 C C   . ILE A 1 737 ? -1.680  69.133  64.491  1.00 89.24  ?  718 ILE A C   1 
ATOM   4327 O O   . ILE A 1 737 ? -2.308  68.876  65.527  1.00 90.23  ?  718 ILE A O   1 
ATOM   4328 C CB  . ILE A 1 737 ? -0.230  67.126  63.957  1.00 90.35  ?  718 ILE A CB  1 
ATOM   4329 C CG1 . ILE A 1 737 ? 1.199   66.642  63.694  1.00 79.34  ?  718 ILE A CG1 1 
ATOM   4330 C CG2 . ILE A 1 737 ? -1.121  66.830  62.795  1.00 88.11  ?  718 ILE A CG2 1 
ATOM   4331 C CD1 . ILE A 1 737 ? 1.919   67.407  62.633  1.00 82.55  ?  718 ILE A CD1 1 
ATOM   4332 N N   . SER A 1 738 ? -2.183  69.852  63.485  1.00 93.92  ?  719 SER A N   1 
ATOM   4333 C CA  . SER A 1 738 ? -3.492  70.494  63.551  1.00 92.97  ?  719 SER A CA  1 
ATOM   4334 C C   . SER A 1 738 ? -4.616  69.462  63.628  1.00 91.95  ?  719 SER A C   1 
ATOM   4335 O O   . SER A 1 738 ? -4.455  68.300  63.248  1.00 88.54  ?  719 SER A O   1 
ATOM   4336 C CB  . SER A 1 738 ? -3.707  71.404  62.336  1.00 97.69  ?  719 SER A CB  1 
ATOM   4337 O OG  . SER A 1 738 ? -3.797  70.660  61.127  1.00 93.84  ?  719 SER A OG  1 
ATOM   4338 N N   . ASP A 1 739 ? -5.771  69.912  64.135  1.00 93.99  ?  720 ASP A N   1 
ATOM   4339 C CA  . ASP A 1 739 ? -6.955  69.057  64.230  1.00 92.26  ?  720 ASP A CA  1 
ATOM   4340 C C   . ASP A 1 739 ? -7.251  68.359  62.909  1.00 96.27  ?  720 ASP A C   1 
ATOM   4341 O O   . ASP A 1 739 ? -7.420  67.134  62.856  1.00 96.37  ?  720 ASP A O   1 
ATOM   4342 C CB  . ASP A 1 739 ? -8.181  69.879  64.643  1.00 98.97  ?  720 ASP A CB  1 
ATOM   4343 C CG  . ASP A 1 739 ? -8.191  70.250  66.112  1.00 103.99 ?  720 ASP A CG  1 
ATOM   4344 O OD1 . ASP A 1 739 ? -9.229  70.802  66.555  1.00 109.26 ?  720 ASP A OD1 1 
ATOM   4345 O OD2 . ASP A 1 739 ? -7.191  69.981  66.819  1.00 101.96 ?  720 ASP A OD2 1 
ATOM   4346 N N   . ASP A 1 740 ? -7.325  69.134  61.826  1.00 100.05 ?  721 ASP A N   1 
ATOM   4347 C CA  . ASP A 1 740 ? -7.799  68.596  60.556  1.00 97.72  ?  721 ASP A CA  1 
ATOM   4348 C C   . ASP A 1 740 ? -6.850  67.529  60.009  1.00 94.30  ?  721 ASP A C   1 
ATOM   4349 O O   . ASP A 1 740 ? -7.297  66.451  59.600  1.00 94.62  ?  721 ASP A O   1 
ATOM   4350 C CB  . ASP A 1 740 ? -8.026  69.748  59.577  1.00 95.39  ?  721 ASP A CB  1 
ATOM   4351 C CG  . ASP A 1 740 ? -9.201  70.641  60.004  1.00 106.55 ?  721 ASP A CG  1 
ATOM   4352 O OD1 . ASP A 1 740 ? -10.243 70.082  60.428  1.00 108.72 ?  721 ASP A OD1 1 
ATOM   4353 O OD2 . ASP A 1 740 ? -9.080  71.889  59.953  1.00 109.59 ?  721 ASP A OD2 1 
ATOM   4354 N N   . VAL A 1 741 ? -5.542  67.783  60.040  1.00 85.76  ?  722 VAL A N   1 
ATOM   4355 C CA  . VAL A 1 741 ? -4.577  66.737  59.723  1.00 83.78  ?  722 VAL A CA  1 
ATOM   4356 C C   . VAL A 1 741 ? -4.816  65.483  60.573  1.00 92.18  ?  722 VAL A C   1 
ATOM   4357 O O   . VAL A 1 741 ? -4.808  64.354  60.061  1.00 94.27  ?  722 VAL A O   1 
ATOM   4358 C CB  . VAL A 1 741 ? -3.160  67.293  59.905  1.00 87.63  ?  722 VAL A CB  1 
ATOM   4359 C CG1 . VAL A 1 741 ? -2.148  66.257  59.601  1.00 87.30  ?  722 VAL A CG1 1 
ATOM   4360 C CG2 . VAL A 1 741 ? -2.955  68.494  59.031  1.00 89.56  ?  722 VAL A CG2 1 
ATOM   4361 N N   . ILE A 1 742 ? -5.046  65.658  61.879  1.00 92.70  ?  723 ILE A N   1 
ATOM   4362 C CA  . ILE A 1 742 ? -5.241  64.515  62.773  1.00 91.27  ?  723 ILE A CA  1 
ATOM   4363 C C   . ILE A 1 742 ? -6.563  63.820  62.474  1.00 92.47  ?  723 ILE A C   1 
ATOM   4364 O O   . ILE A 1 742 ? -6.621  62.588  62.363  1.00 90.23  ?  723 ILE A O   1 
ATOM   4365 C CB  . ILE A 1 742 ? -5.168  64.956  64.250  1.00 94.25  ?  723 ILE A CB  1 
ATOM   4366 C CG1 . ILE A 1 742 ? -3.727  65.218  64.681  1.00 95.23  ?  723 ILE A CG1 1 
ATOM   4367 C CG2 . ILE A 1 742 ? -5.781  63.899  65.182  1.00 85.09  ?  723 ILE A CG2 1 
ATOM   4368 C CD1 . ILE A 1 742 ? -3.611  65.576  66.149  1.00 95.05  ?  723 ILE A CD1 1 
ATOM   4369 N N   . VAL A 1 743 ? -7.654  64.590  62.362  1.00 95.52  ?  724 VAL A N   1 
ATOM   4370 C CA  . VAL A 1 743 ? -8.943  63.958  62.079  1.00 99.97  ?  724 VAL A CA  1 
ATOM   4371 C C   . VAL A 1 743 ? -8.878  63.238  60.733  1.00 96.47  ?  724 VAL A C   1 
ATOM   4372 O O   . VAL A 1 743 ? -9.554  62.223  60.535  1.00 92.82  ?  724 VAL A O   1 
ATOM   4373 C CB  . VAL A 1 743 ? -10.105 64.983  62.125  1.00 95.62  ?  724 VAL A CB  1 
ATOM   4374 C CG1 . VAL A 1 743 ? -11.441 64.307  61.807  1.00 93.27  ?  724 VAL A CG1 1 
ATOM   4375 C CG2 . VAL A 1 743 ? -10.188 65.670  63.464  1.00 87.13  ?  724 VAL A CG2 1 
ATOM   4376 N N   . GLY A 1 744 ? -8.042  63.731  59.807  1.00 94.30  ?  725 GLY A N   1 
ATOM   4377 C CA  . GLY A 1 744 ? -7.776  63.079  58.538  1.00 91.49  ?  725 GLY A CA  1 
ATOM   4378 C C   . GLY A 1 744 ? -7.202  61.680  58.679  1.00 94.13  ?  725 GLY A C   1 
ATOM   4379 O O   . GLY A 1 744 ? -7.788  60.703  58.188  1.00 91.91  ?  725 GLY A O   1 
ATOM   4380 N N   . ARG A 1 745 ? -6.057  61.562  59.359  1.00 87.95  ?  726 ARG A N   1 
ATOM   4381 C CA  . ARG A 1 745 ? -5.472  60.245  59.557  1.00 82.17  ?  726 ARG A CA  1 
ATOM   4382 C C   . ARG A 1 745 ? -6.457  59.286  60.218  1.00 90.88  ?  726 ARG A C   1 
ATOM   4383 O O   . ARG A 1 745 ? -6.382  58.072  59.984  1.00 93.43  ?  726 ARG A O   1 
ATOM   4384 C CB  . ARG A 1 745 ? -4.191  60.357  60.377  1.00 80.98  ?  726 ARG A CB  1 
ATOM   4385 C CG  . ARG A 1 745 ? -3.348  61.552  60.058  1.00 81.16  ?  726 ARG A CG  1 
ATOM   4386 C CD  . ARG A 1 745 ? -1.989  61.400  60.695  1.00 87.02  ?  726 ARG A CD  1 
ATOM   4387 N NE  . ARG A 1 745 ? -1.081  62.491  60.352  1.00 89.29  ?  726 ARG A NE  1 
ATOM   4388 C CZ  . ARG A 1 745 ? 0.185   62.551  60.756  1.00 91.47  ?  726 ARG A CZ  1 
ATOM   4389 N NH1 . ARG A 1 745 ? 0.677   61.587  61.517  1.00 93.60  ?  726 ARG A NH1 1 
ATOM   4390 N NH2 . ARG A 1 745 ? 0.959   63.570  60.410  1.00 91.95  ?  726 ARG A NH2 1 
ATOM   4391 N N   . CYS A 1 746 ? -7.389  59.806  61.036  1.00 91.24  ?  727 CYS A N   1 
ATOM   4392 C CA  . CYS A 1 746 ? -8.416  58.958  61.652  1.00 90.84  ?  727 CYS A CA  1 
ATOM   4393 C C   . CYS A 1 746 ? -9.390  58.408  60.623  1.00 92.43  ?  727 CYS A C   1 
ATOM   4394 O O   . CYS A 1 746 ? -9.812  57.251  60.713  1.00 93.27  ?  727 CYS A O   1 
ATOM   4395 C CB  . CYS A 1 746 ? -9.210  59.722  62.713  1.00 90.01  ?  727 CYS A CB  1 
ATOM   4396 S SG  . CYS A 1 746 ? -8.393  60.023  64.267  1.00 98.72  ?  727 CYS A SG  1 
ATOM   4397 N N   . LEU A 1 747 ? -9.801  59.240  59.673  1.00 95.40  ?  728 LEU A N   1 
ATOM   4398 C CA  . LEU A 1 747 ? -10.765 58.796  58.679  1.00 97.54  ?  728 LEU A CA  1 
ATOM   4399 C C   . LEU A 1 747 ? -10.116 57.819  57.708  1.00 98.24  ?  728 LEU A C   1 
ATOM   4400 O O   . LEU A 1 747 ? -10.699 56.771  57.389  1.00 96.54  ?  728 LEU A O   1 
ATOM   4401 C CB  . LEU A 1 747 ? -11.353 60.012  57.963  1.00 95.62  ?  728 LEU A CB  1 
ATOM   4402 C CG  . LEU A 1 747 ? -12.025 60.992  58.944  1.00 97.19  ?  728 LEU A CG  1 
ATOM   4403 C CD1 . LEU A 1 747 ? -12.568 62.234  58.251  1.00 96.34  ?  728 LEU A CD1 1 
ATOM   4404 C CD2 . LEU A 1 747 ? -13.121 60.306  59.781  1.00 95.49  ?  728 LEU A CD2 1 
ATOM   4405 N N   . ALA A 1 748 ? -8.896  58.132  57.256  1.00 94.72  ?  729 ALA A N   1 
ATOM   4406 C CA  . ALA A 1 748 ? -8.107  57.168  56.498  1.00 91.15  ?  729 ALA A CA  1 
ATOM   4407 C C   . ALA A 1 748 ? -8.127  55.798  57.174  1.00 97.07  ?  729 ALA A C   1 
ATOM   4408 O O   . ALA A 1 748 ? -8.634  54.820  56.612  1.00 98.40  ?  729 ALA A O   1 
ATOM   4409 C CB  . ALA A 1 748 ? -6.674  57.680  56.338  1.00 83.01  ?  729 ALA A CB  1 
ATOM   4410 N N   . ILE A 1 749 ? -7.610  55.720  58.404  1.00 95.47  ?  730 ILE A N   1 
ATOM   4411 C CA  . ILE A 1 749 ? -7.560  54.441  59.099  1.00 92.05  ?  730 ILE A CA  1 
ATOM   4412 C C   . ILE A 1 749 ? -8.946  53.807  59.153  1.00 94.47  ?  730 ILE A C   1 
ATOM   4413 O O   . ILE A 1 749 ? -9.095  52.596  58.945  1.00 99.74  ?  730 ILE A O   1 
ATOM   4414 C CB  . ILE A 1 749 ? -6.944  54.620  60.500  1.00 91.27  ?  730 ILE A CB  1 
ATOM   4415 C CG1 . ILE A 1 749 ? -5.506  55.137  60.370  1.00 93.70  ?  730 ILE A CG1 1 
ATOM   4416 C CG2 . ILE A 1 749 ? -6.964  53.294  61.268  1.00 85.00  ?  730 ILE A CG2 1 
ATOM   4417 C CD1 . ILE A 1 749 ? -4.908  55.583  61.660  1.00 89.33  ?  730 ILE A CD1 1 
ATOM   4418 N N   . LEU A 1 750 ? -9.987  54.617  59.371  1.00 93.53  ?  731 LEU A N   1 
ATOM   4419 C CA  . LEU A 1 750 ? -11.347 54.080  59.441  1.00 97.31  ?  731 LEU A CA  1 
ATOM   4420 C C   . LEU A 1 750 ? -11.867 53.656  58.062  1.00 103.46 ?  731 LEU A C   1 
ATOM   4421 O O   . LEU A 1 750 ? -12.627 52.678  57.957  1.00 101.26 ?  731 LEU A O   1 
ATOM   4422 C CB  . LEU A 1 750 ? -12.292 55.105  60.079  1.00 93.20  ?  731 LEU A CB  1 
ATOM   4423 C CG  . LEU A 1 750 ? -12.236 55.327  61.595  1.00 89.03  ?  731 LEU A CG  1 
ATOM   4424 C CD1 . LEU A 1 750 ? -13.342 56.244  62.027  1.00 92.88  ?  731 LEU A CD1 1 
ATOM   4425 C CD2 . LEU A 1 750 ? -12.336 54.029  62.365  1.00 91.25  ?  731 LEU A CD2 1 
ATOM   4426 N N   . LYS A 1 751 ? -11.500 54.391  56.996  1.00 98.63  ?  732 LYS A N   1 
ATOM   4427 C CA  . LYS A 1 751 ? -11.832 53.950  55.638  1.00 100.15 ?  732 LYS A CA  1 
ATOM   4428 C C   . LYS A 1 751 ? -11.183 52.599  55.324  1.00 102.86 ?  732 LYS A C   1 
ATOM   4429 O O   . LYS A 1 751 ? -11.830 51.690  54.790  1.00 100.70 ?  732 LYS A O   1 
ATOM   4430 C CB  . LYS A 1 751 ? -11.394 54.998  54.612  1.00 98.44  ?  732 LYS A CB  1 
ATOM   4431 C CG  . LYS A 1 751 ? -12.183 56.302  54.630  1.00 100.91 ?  732 LYS A CG  1 
ATOM   4432 C CD  . LYS A 1 751 ? -11.709 57.262  53.522  1.00 100.19 ?  732 LYS A CD  1 
ATOM   4433 C CE  . LYS A 1 751 ? -12.321 58.653  53.680  1.00 100.15 ?  732 LYS A CE  1 
ATOM   4434 N NZ  . LYS A 1 751 ? -13.816 58.614  53.629  1.00 106.91 ?  732 LYS A NZ  1 
ATOM   4435 N N   . GLY A 1 752 ? -9.896  52.454  55.654  1.00 100.88 ?  733 GLY A N   1 
ATOM   4436 C CA  . GLY A 1 752 ? -9.237  51.173  55.487  1.00 96.00  ?  733 GLY A CA  1 
ATOM   4437 C C   . GLY A 1 752 ? -9.979  50.033  56.156  1.00 100.72 ?  733 GLY A C   1 
ATOM   4438 O O   . GLY A 1 752 ? -10.090 48.941  55.594  1.00 106.03 ?  733 GLY A O   1 
ATOM   4439 N N   . ILE A 1 753 ? -10.500 50.261  57.364  1.00 99.19  ?  734 ILE A N   1 
ATOM   4440 C CA  . ILE A 1 753 ? -11.146 49.160  58.076  1.00 101.10 ?  734 ILE A CA  1 
ATOM   4441 C C   . ILE A 1 753 ? -12.511 48.871  57.474  1.00 100.83 ?  734 ILE A C   1 
ATOM   4442 O O   . ILE A 1 753 ? -12.884 47.709  57.279  1.00 105.73 ?  734 ILE A O   1 
ATOM   4443 C CB  . ILE A 1 753 ? -11.263 49.444  59.590  1.00 100.89 ?  734 ILE A CB  1 
ATOM   4444 C CG1 . ILE A 1 753 ? -9.908  49.794  60.207  1.00 101.70 ?  734 ILE A CG1 1 
ATOM   4445 C CG2 . ILE A 1 753 ? -11.876 48.248  60.316  1.00 95.76  ?  734 ILE A CG2 1 
ATOM   4446 C CD1 . ILE A 1 753 ? -8.829  48.818  59.912  1.00 99.10  ?  734 ILE A CD1 1 
ATOM   4447 N N   . PHE A 1 754 ? -13.272 49.914  57.162  1.00 101.07 ?  735 PHE A N   1 
ATOM   4448 C CA  . PHE A 1 754 ? -14.692 49.774  56.884  1.00 101.50 ?  735 PHE A CA  1 
ATOM   4449 C C   . PHE A 1 754 ? -15.061 50.098  55.442  1.00 101.92 ?  735 PHE A C   1 
ATOM   4450 O O   . PHE A 1 754 ? -16.238 49.984  55.078  1.00 100.22 ?  735 PHE A O   1 
ATOM   4451 C CB  . PHE A 1 754 ? -15.503 50.661  57.848  1.00 101.03 ?  735 PHE A CB  1 
ATOM   4452 C CG  . PHE A 1 754 ? -15.456 50.205  59.289  1.00 101.89 ?  735 PHE A CG  1 
ATOM   4453 C CD1 . PHE A 1 754 ? -16.345 49.252  59.760  1.00 101.35 ?  735 PHE A CD1 1 
ATOM   4454 C CD2 . PHE A 1 754 ? -14.528 50.732  60.174  1.00 101.20 ?  735 PHE A CD2 1 
ATOM   4455 C CE1 . PHE A 1 754 ? -16.307 48.824  61.085  1.00 100.30 ?  735 PHE A CE1 1 
ATOM   4456 C CE2 . PHE A 1 754 ? -14.486 50.303  61.499  1.00 98.39  ?  735 PHE A CE2 1 
ATOM   4457 C CZ  . PHE A 1 754 ? -15.380 49.349  61.953  1.00 94.28  ?  735 PHE A CZ  1 
ATOM   4458 N N   . GLY A 1 755 ? -14.099 50.494  54.612  1.00 99.88  ?  736 GLY A N   1 
ATOM   4459 C CA  . GLY A 1 755 ? -14.394 50.791  53.223  1.00 101.26 ?  736 GLY A CA  1 
ATOM   4460 C C   . GLY A 1 755 ? -14.685 52.257  52.997  1.00 101.22 ?  736 GLY A C   1 
ATOM   4461 O O   . GLY A 1 755 ? -15.373 52.880  53.809  1.00 100.60 ?  736 GLY A O   1 
ATOM   4462 N N   . SER A 1 756 ? -14.206 52.804  51.875  1.00 102.09 ?  737 SER A N   1 
ATOM   4463 C CA  . SER A 1 756 ? -14.126 54.247  51.673  1.00 101.35 ?  737 SER A CA  1 
ATOM   4464 C C   . SER A 1 756 ? -15.484 54.944  51.564  1.00 106.22 ?  737 SER A C   1 
ATOM   4465 O O   . SER A 1 756 ? -15.522 56.181  51.480  1.00 107.26 ?  737 SER A O   1 
ATOM   4466 C CB  . SER A 1 756 ? -13.286 54.533  50.424  1.00 99.59  ?  737 SER A CB  1 
ATOM   4467 O OG  . SER A 1 756 ? -13.044 55.922  50.283  1.00 103.11 ?  737 SER A OG  1 
ATOM   4468 N N   . SER A 1 757 ? -16.596 54.210  51.583  1.00 109.16 ?  738 SER A N   1 
ATOM   4469 C CA  . SER A 1 757 ? -17.905 54.830  51.424  1.00 114.79 ?  738 SER A CA  1 
ATOM   4470 C C   . SER A 1 757 ? -18.795 54.735  52.657  1.00 112.74 ?  738 SER A C   1 
ATOM   4471 O O   . SER A 1 757 ? -19.815 55.430  52.712  1.00 116.26 ?  738 SER A O   1 
ATOM   4472 C CB  . SER A 1 757 ? -18.645 54.214  50.224  1.00 118.41 ?  738 SER A CB  1 
ATOM   4473 O OG  . SER A 1 757 ? -19.035 52.880  50.504  1.00 120.51 ?  738 SER A OG  1 
ATOM   4474 N N   . ALA A 1 758 ? -18.447 53.908  53.645  1.00 110.43 ?  739 ALA A N   1 
ATOM   4475 C CA  . ALA A 1 758 ? -19.255 53.762  54.852  1.00 109.79 ?  739 ALA A CA  1 
ATOM   4476 C C   . ALA A 1 758 ? -18.925 54.790  55.937  1.00 110.31 ?  739 ALA A C   1 
ATOM   4477 O O   . ALA A 1 758 ? -19.611 54.816  56.965  1.00 108.95 ?  739 ALA A O   1 
ATOM   4478 C CB  . ALA A 1 758 ? -19.095 52.349  55.424  1.00 99.65  ?  739 ALA A CB  1 
ATOM   4479 N N   . VAL A 1 759 ? -17.919 55.632  55.728  1.00 109.10 ?  740 VAL A N   1 
ATOM   4480 C CA  . VAL A 1 759 ? -17.406 56.583  56.720  1.00 105.53 ?  740 VAL A CA  1 
ATOM   4481 C C   . VAL A 1 759 ? -17.789 57.990  56.292  1.00 104.48 ?  740 VAL A C   1 
ATOM   4482 O O   . VAL A 1 759 ? -17.178 58.544  55.360  1.00 104.49 ?  740 VAL A O   1 
ATOM   4483 C CB  . VAL A 1 759 ? -15.890 56.453  56.888  1.00 107.10 ?  740 VAL A CB  1 
ATOM   4484 C CG1 . VAL A 1 759 ? -15.360 57.619  57.710  1.00 103.59 ?  740 VAL A CG1 1 
ATOM   4485 C CG2 . VAL A 1 759 ? -15.572 55.138  57.589  1.00 105.81 ?  740 VAL A CG2 1 
ATOM   4486 N N   . PRO A 1 760 ? -18.754 58.630  56.955  1.00 103.53 ?  741 PRO A N   1 
ATOM   4487 C CA  . PRO A 1 760 ? -19.099 60.019  56.642  1.00 103.36 ?  741 PRO A CA  1 
ATOM   4488 C C   . PRO A 1 760 ? -18.089 60.971  57.254  1.00 105.87 ?  741 PRO A C   1 
ATOM   4489 O O   . PRO A 1 760 ? -17.412 60.646  58.230  1.00 109.67 ?  741 PRO A O   1 
ATOM   4490 C CB  . PRO A 1 760 ? -20.474 60.210  57.302  1.00 99.10  ?  741 PRO A CB  1 
ATOM   4491 C CG  . PRO A 1 760 ? -20.837 58.868  57.907  1.00 105.04 ?  741 PRO A CG  1 
ATOM   4492 C CD  . PRO A 1 760 ? -19.561 58.109  58.069  1.00 103.20 ?  741 PRO A CD  1 
ATOM   4493 N N   . GLN A 1 761 ? -18.003 62.168  56.687  1.00 105.40 ?  742 GLN A N   1 
ATOM   4494 C CA  . GLN A 1 761 ? -17.213 63.196  57.351  1.00 106.97 ?  742 GLN A CA  1 
ATOM   4495 C C   . GLN A 1 761 ? -17.823 63.472  58.720  1.00 109.39 ?  742 GLN A C   1 
ATOM   4496 O O   . GLN A 1 761 ? -19.057 63.556  58.837  1.00 107.70 ?  742 GLN A O   1 
ATOM   4497 C CB  . GLN A 1 761 ? -17.136 64.476  56.527  1.00 102.39 ?  742 GLN A CB  1 
ATOM   4498 C CG  . GLN A 1 761 ? -16.250 64.312  55.308  1.00 114.76 ?  742 GLN A CG  1 
ATOM   4499 C CD  . GLN A 1 761 ? -14.785 64.087  55.664  1.00 116.30 ?  742 GLN A CD  1 
ATOM   4500 O OE1 . GLN A 1 761 ? -14.227 64.784  56.519  1.00 113.17 ?  742 GLN A OE1 1 
ATOM   4501 N NE2 . GLN A 1 761 ? -14.157 63.095  55.015  1.00 112.62 ?  742 GLN A NE2 1 
ATOM   4502 N N   . PRO A 1 762 ? -17.014 63.562  59.780  1.00 108.78 ?  743 PRO A N   1 
ATOM   4503 C CA  . PRO A 1 762 ? -17.578 63.748  61.119  1.00 103.82 ?  743 PRO A CA  1 
ATOM   4504 C C   . PRO A 1 762 ? -18.179 65.132  61.286  1.00 100.65 ?  743 PRO A C   1 
ATOM   4505 O O   . PRO A 1 762 ? -17.681 66.130  60.753  1.00 94.80  ?  743 PRO A O   1 
ATOM   4506 C CB  . PRO A 1 762 ? -16.376 63.541  62.042  1.00 97.98  ?  743 PRO A CB  1 
ATOM   4507 C CG  . PRO A 1 762 ? -15.205 63.873  61.207  1.00 99.30  ?  743 PRO A CG  1 
ATOM   4508 C CD  . PRO A 1 762 ? -15.547 63.454  59.812  1.00 104.18 ?  743 PRO A CD  1 
ATOM   4509 N N   . LYS A 1 763 ? -19.277 65.174  62.032  1.00 97.86  ?  744 LYS A N   1 
ATOM   4510 C CA  . LYS A 1 763 ? -19.970 66.432  62.260  1.00 106.79 ?  744 LYS A CA  1 
ATOM   4511 C C   . LYS A 1 763 ? -19.209 67.322  63.244  1.00 107.85 ?  744 LYS A C   1 
ATOM   4512 O O   . LYS A 1 763 ? -19.004 68.514  62.979  1.00 103.98 ?  744 LYS A O   1 
ATOM   4513 C CB  . LYS A 1 763 ? -21.396 66.141  62.735  1.00 108.52 ?  744 LYS A CB  1 
ATOM   4514 C CG  . LYS A 1 763 ? -22.268 65.576  61.606  1.00 118.46 ?  744 LYS A CG  1 
ATOM   4515 C CD  . LYS A 1 763 ? -22.372 66.586  60.425  1.00 119.14 ?  744 LYS A CD  1 
ATOM   4516 C CE  . LYS A 1 763 ? -22.711 65.918  59.083  1.00 111.13 ?  744 LYS A CE  1 
ATOM   4517 N NZ  . LYS A 1 763 ? -23.999 65.180  59.124  1.00 111.22 ?  744 LYS A NZ  1 
ATOM   4518 N N   . GLU A 1 764 ? -18.754 66.746  64.371  1.00 109.27 ?  745 GLU A N   1 
ATOM   4519 C CA  . GLU A 1 764 ? -17.994 67.442  65.407  1.00 106.95 ?  745 GLU A CA  1 
ATOM   4520 C C   . GLU A 1 764 ? -16.695 66.692  65.709  1.00 100.17 ?  745 GLU A C   1 
ATOM   4521 O O   . GLU A 1 764 ? -16.670 65.457  65.714  1.00 94.89  ?  745 GLU A O   1 
ATOM   4522 C CB  . GLU A 1 764 ? -18.837 67.594  66.697  1.00 109.60 ?  745 GLU A CB  1 
ATOM   4523 C CG  . GLU A 1 764 ? -20.078 68.511  66.577  1.00 111.96 ?  745 GLU A CG  1 
ATOM   4524 C CD  . GLU A 1 764 ? -19.735 69.988  66.357  1.00 112.19 ?  745 GLU A CD  1 
ATOM   4525 O OE1 . GLU A 1 764 ? -18.601 70.399  66.706  1.00 110.94 ?  745 GLU A OE1 1 
ATOM   4526 O OE2 . GLU A 1 764 ? -20.603 70.732  65.828  1.00 114.88 ?  745 GLU A OE2 1 
ATOM   4527 N N   . THR A 1 765 ? -15.618 67.442  65.971  1.00 99.31  ?  746 THR A N   1 
ATOM   4528 C CA  . THR A 1 765 ? -14.296 66.862  66.214  1.00 93.16  ?  746 THR A CA  1 
ATOM   4529 C C   . THR A 1 765 ? -13.542 67.639  67.286  1.00 92.93  ?  746 THR A C   1 
ATOM   4530 O O   . THR A 1 765 ? -13.267 68.834  67.115  1.00 96.36  ?  746 THR A O   1 
ATOM   4531 C CB  . THR A 1 765 ? -13.471 66.836  64.934  1.00 90.69  ?  746 THR A CB  1 
ATOM   4532 O OG1 . THR A 1 765 ? -13.692 68.059  64.217  1.00 95.67  ?  746 THR A OG1 1 
ATOM   4533 C CG2 . THR A 1 765 ? -13.851 65.643  64.094  1.00 92.17  ?  746 THR A CG2 1 
ATOM   4534 N N   . VAL A 1 766 ? -13.167 66.932  68.357  1.00 88.77  ?  747 VAL A N   1 
ATOM   4535 C CA  . VAL A 1 766 ? -12.381 67.449  69.472  1.00 80.63  ?  747 VAL A CA  1 
ATOM   4536 C C   . VAL A 1 766 ? -11.078 66.669  69.550  1.00 79.70  ?  747 VAL A C   1 
ATOM   4537 O O   . VAL A 1 766 ? -11.097 65.436  69.572  1.00 84.03  ?  747 VAL A O   1 
ATOM   4538 C CB  . VAL A 1 766 ? -13.127 67.301  70.806  1.00 82.48  ?  747 VAL A CB  1 
ATOM   4539 C CG1 . VAL A 1 766 ? -12.329 67.948  71.898  1.00 81.71  ?  747 VAL A CG1 1 
ATOM   4540 C CG2 . VAL A 1 766 ? -14.518 67.877  70.727  1.00 87.70  ?  747 VAL A CG2 1 
ATOM   4541 N N   . VAL A 1 767 ? -9.957  67.375  69.645  1.00 83.04  ?  748 VAL A N   1 
ATOM   4542 C CA  . VAL A 1 767 ? -8.661  66.755  69.905  1.00 81.28  ?  748 VAL A CA  1 
ATOM   4543 C C   . VAL A 1 767 ? -8.095  67.340  71.196  1.00 82.52  ?  748 VAL A C   1 
ATOM   4544 O O   . VAL A 1 767 ? -7.943  68.563  71.304  1.00 83.62  ?  748 VAL A O   1 
ATOM   4545 C CB  . VAL A 1 767 ? -7.684  66.980  68.740  1.00 78.49  ?  748 VAL A CB  1 
ATOM   4546 C CG1 . VAL A 1 767 ? -6.263  66.676  69.169  1.00 79.20  ?  748 VAL A CG1 1 
ATOM   4547 C CG2 . VAL A 1 767 ? -8.075  66.144  67.573  1.00 85.73  ?  748 VAL A CG2 1 
ATOM   4548 N N   . SER A 1 768 ? -7.769  66.471  72.162  1.00 74.00  ?  749 SER A N   1 
ATOM   4549 C CA  . SER A 1 768 ? -7.140  66.890  73.411  1.00 68.96  ?  749 SER A CA  1 
ATOM   4550 C C   . SER A 1 768 ? -5.632  67.077  73.237  1.00 73.03  ?  749 SER A C   1 
ATOM   4551 O O   . SER A 1 768 ? -4.991  66.406  72.418  1.00 77.39  ?  749 SER A O   1 
ATOM   4552 C CB  . SER A 1 768 ? -7.366  65.860  74.512  1.00 66.07  ?  749 SER A CB  1 
ATOM   4553 O OG  . SER A 1 768 ? -6.338  64.882  74.498  1.00 69.01  ?  749 SER A OG  1 
ATOM   4554 N N   . ARG A 1 769 ? -5.060  68.011  74.035  1.00 64.58  ?  750 ARG A N   1 
ATOM   4555 C CA  . ARG A 1 769 ? -3.605  68.250  74.125  1.00 70.56  ?  750 ARG A CA  1 
ATOM   4556 C C   . ARG A 1 769 ? -3.248  68.481  75.591  1.00 75.12  ?  750 ARG A C   1 
ATOM   4557 O O   . ARG A 1 769 ? -3.107  69.623  76.045  1.00 76.45  ?  750 ARG A O   1 
ATOM   4558 C CB  . ARG A 1 769 ? -3.159  69.439  73.304  1.00 72.21  ?  750 ARG A CB  1 
ATOM   4559 C CG  . ARG A 1 769 ? -3.258  69.264  71.866  1.00 74.02  ?  750 ARG A CG  1 
ATOM   4560 C CD  . ARG A 1 769 ? -2.845  70.529  71.175  1.00 77.68  ?  750 ARG A CD  1 
ATOM   4561 N NE  . ARG A 1 769 ? -2.930  70.244  69.769  1.00 95.40  ?  750 ARG A NE  1 
ATOM   4562 C CZ  . ARG A 1 769 ? -4.081  70.272  69.094  1.00 101.03 ?  750 ARG A CZ  1 
ATOM   4563 N NH1 . ARG A 1 769 ? -5.250  70.477  69.719  1.00 98.41  ?  750 ARG A NH1 1 
ATOM   4564 N NH2 . ARG A 1 769 ? -4.068  70.007  67.777  1.00 89.83  ?  750 ARG A NH2 1 
ATOM   4565 N N   . TRP A 1 770 ? -3.064  67.390  76.322  1.00 70.19  ?  751 TRP A N   1 
ATOM   4566 C CA  . TRP A 1 770 ? -2.906  67.506  77.753  1.00 64.15  ?  751 TRP A CA  1 
ATOM   4567 C C   . TRP A 1 770 ? -1.525  68.007  78.126  1.00 68.23  ?  751 TRP A C   1 
ATOM   4568 O O   . TRP A 1 770 ? -1.386  68.716  79.127  1.00 69.54  ?  751 TRP A O   1 
ATOM   4569 C CB  . TRP A 1 770 ? -3.212  66.162  78.400  1.00 62.16  ?  751 TRP A CB  1 
ATOM   4570 C CG  . TRP A 1 770 ? -4.670  65.906  78.456  1.00 62.47  ?  751 TRP A CG  1 
ATOM   4571 C CD1 . TRP A 1 770 ? -5.371  65.091  77.652  1.00 64.00  ?  751 TRP A CD1 1 
ATOM   4572 C CD2 . TRP A 1 770 ? -5.617  66.493  79.363  1.00 65.78  ?  751 TRP A CD2 1 
ATOM   4573 N NE1 . TRP A 1 770 ? -6.700  65.106  77.995  1.00 66.23  ?  751 TRP A NE1 1 
ATOM   4574 C CE2 . TRP A 1 770 ? -6.881  65.964  79.041  1.00 62.18  ?  751 TRP A CE2 1 
ATOM   4575 C CE3 . TRP A 1 770 ? -5.514  67.404  80.422  1.00 60.93  ?  751 TRP A CE3 1 
ATOM   4576 C CZ2 . TRP A 1 770 ? -8.040  66.322  79.724  1.00 60.98  ?  751 TRP A CZ2 1 
ATOM   4577 C CZ3 . TRP A 1 770 ? -6.655  67.741  81.114  1.00 56.25  ?  751 TRP A CZ3 1 
ATOM   4578 C CH2 . TRP A 1 770 ? -7.906  67.201  80.763  1.00 63.60  ?  751 TRP A CH2 1 
ATOM   4579 N N   . ARG A 1 771 ? -0.491  67.680  77.349  1.00 65.31  ?  752 ARG A N   1 
ATOM   4580 C CA  . ARG A 1 771 ? 0.806   68.250  77.686  1.00 64.85  ?  752 ARG A CA  1 
ATOM   4581 C C   . ARG A 1 771 ? 0.818   69.763  77.450  1.00 69.38  ?  752 ARG A C   1 
ATOM   4582 O O   . ARG A 1 771 ? 1.606   70.490  78.070  1.00 68.60  ?  752 ARG A O   1 
ATOM   4583 C CB  . ARG A 1 771 ? 1.898   67.531  76.896  1.00 60.92  ?  752 ARG A CB  1 
ATOM   4584 C CG  . ARG A 1 771 ? 3.332   67.876  77.264  1.00 57.53  ?  752 ARG A CG  1 
ATOM   4585 C CD  . ARG A 1 771 ? 3.755   67.281  78.598  1.00 65.34  ?  752 ARG A CD  1 
ATOM   4586 N NE  . ARG A 1 771 ? 4.042   65.842  78.552  1.00 65.91  ?  752 ARG A NE  1 
ATOM   4587 C CZ  . ARG A 1 771 ? 4.178   65.090  79.639  1.00 63.08  ?  752 ARG A CZ  1 
ATOM   4588 N NH1 . ARG A 1 771 ? 4.042   65.645  80.831  1.00 70.57  ?  752 ARG A NH1 1 
ATOM   4589 N NH2 . ARG A 1 771 ? 4.434   63.793  79.556  1.00 61.35  ?  752 ARG A NH2 1 
ATOM   4590 N N   . ALA A 1 772 ? -0.075  70.261  76.600  1.00 73.06  ?  753 ALA A N   1 
ATOM   4591 C CA  . ALA A 1 772 ? -0.110  71.690  76.333  1.00 69.76  ?  753 ALA A CA  1 
ATOM   4592 C C   . ALA A 1 772 ? -0.968  72.431  77.348  1.00 71.55  ?  753 ALA A C   1 
ATOM   4593 O O   . ALA A 1 772 ? -0.677  73.591  77.676  1.00 72.39  ?  753 ALA A O   1 
ATOM   4594 C CB  . ALA A 1 772 ? -0.631  71.929  74.923  1.00 67.08  ?  753 ALA A CB  1 
ATOM   4595 N N   . ASP A 1 773 ? -2.038  71.784  77.827  1.00 67.15  ?  754 ASP A N   1 
ATOM   4596 C CA  . ASP A 1 773 ? -2.920  72.339  78.836  1.00 64.77  ?  754 ASP A CA  1 
ATOM   4597 C C   . ASP A 1 773 ? -2.071  72.841  79.993  1.00 69.12  ?  754 ASP A C   1 
ATOM   4598 O O   . ASP A 1 773 ? -1.431  72.049  80.690  1.00 74.98  ?  754 ASP A O   1 
ATOM   4599 C CB  . ASP A 1 773 ? -3.932  71.296  79.303  1.00 56.78  ?  754 ASP A CB  1 
ATOM   4600 C CG  . ASP A 1 773 ? -4.981  71.881  80.232  1.00 69.19  ?  754 ASP A CG  1 
ATOM   4601 O OD1 . ASP A 1 773 ? -4.751  73.002  80.759  1.00 75.18  ?  754 ASP A OD1 1 
ATOM   4602 O OD2 . ASP A 1 773 ? -6.036  71.234  80.446  1.00 70.27  ?  754 ASP A OD2 1 
ATOM   4603 N N   . PRO A 1 774 ? -2.015  74.149  80.228  1.00 71.86  ?  755 PRO A N   1 
ATOM   4604 C CA  . PRO A 1 774 ? -1.113  74.656  81.277  1.00 71.74  ?  755 PRO A CA  1 
ATOM   4605 C C   . PRO A 1 774 ? -1.610  74.400  82.702  1.00 68.79  ?  755 PRO A C   1 
ATOM   4606 O O   . PRO A 1 774 ? -0.875  74.699  83.656  1.00 70.11  ?  755 PRO A O   1 
ATOM   4607 C CB  . PRO A 1 774 ? -1.032  76.143  80.960  1.00 64.75  ?  755 PRO A CB  1 
ATOM   4608 C CG  . PRO A 1 774 ? -2.363  76.430  80.334  1.00 65.92  ?  755 PRO A CG  1 
ATOM   4609 C CD  . PRO A 1 774 ? -2.713  75.231  79.516  1.00 65.97  ?  755 PRO A CD  1 
ATOM   4610 N N   . TRP A 1 775 ? -2.818  73.863  82.881  1.00 64.63  ?  756 TRP A N   1 
ATOM   4611 C CA  . TRP A 1 775 ? -3.290  73.444  84.193  1.00 65.13  ?  756 TRP A CA  1 
ATOM   4612 C C   . TRP A 1 775 ? -3.103  71.952  84.396  1.00 65.73  ?  756 TRP A C   1 
ATOM   4613 O O   . TRP A 1 775 ? -3.679  71.363  85.322  1.00 67.81  ?  756 TRP A O   1 
ATOM   4614 C CB  . TRP A 1 775 ? -4.754  73.860  84.384  1.00 62.88  ?  756 TRP A CB  1 
ATOM   4615 C CG  . TRP A 1 775 ? -5.001  75.285  83.882  1.00 69.93  ?  756 TRP A CG  1 
ATOM   4616 C CD1 . TRP A 1 775 ? -5.928  75.685  82.956  1.00 67.33  ?  756 TRP A CD1 1 
ATOM   4617 C CD2 . TRP A 1 775 ? -4.285  76.481  84.266  1.00 71.03  ?  756 TRP A CD2 1 
ATOM   4618 N NE1 . TRP A 1 775 ? -5.835  77.043  82.745  1.00 68.59  ?  756 TRP A NE1 1 
ATOM   4619 C CE2 . TRP A 1 775 ? -4.848  77.558  83.543  1.00 72.73  ?  756 TRP A CE2 1 
ATOM   4620 C CE3 . TRP A 1 775 ? -3.239  76.747  85.163  1.00 69.53  ?  756 TRP A CE3 1 
ATOM   4621 C CZ2 . TRP A 1 775 ? -4.404  78.883  83.693  1.00 70.23  ?  756 TRP A CZ2 1 
ATOM   4622 C CZ3 . TRP A 1 775 ? -2.786  78.069  85.297  1.00 70.84  ?  756 TRP A CZ3 1 
ATOM   4623 C CH2 . TRP A 1 775 ? -3.367  79.113  84.560  1.00 70.08  ?  756 TRP A CH2 1 
ATOM   4624 N N   . ALA A 1 776 ? -2.305  71.328  83.534  1.00 68.74  ?  757 ALA A N   1 
ATOM   4625 C CA  . ALA A 1 776 ? -2.075  69.894  83.562  1.00 60.17  ?  757 ALA A CA  1 
ATOM   4626 C C   . ALA A 1 776 ? -0.614  69.609  83.239  1.00 57.70  ?  757 ALA A C   1 
ATOM   4627 O O   . ALA A 1 776 ? 0.085   69.025  84.065  1.00 62.15  ?  757 ALA A O   1 
ATOM   4628 C CB  . ALA A 1 776 ? -3.021  69.192  82.597  1.00 51.80  ?  757 ALA A CB  1 
ATOM   4629 N N   . ARG A 1 777 ? -0.116  70.064  82.091  1.00 57.80  ?  758 ARG A N   1 
ATOM   4630 C CA  . ARG A 1 777 ? 1.244   69.726  81.647  1.00 60.69  ?  758 ARG A CA  1 
ATOM   4631 C C   . ARG A 1 777 ? 1.423   68.218  81.478  1.00 64.15  ?  758 ARG A C   1 
ATOM   4632 O O   . ARG A 1 777 ? 2.536   67.704  81.641  1.00 63.68  ?  758 ARG A O   1 
ATOM   4633 C CB  . ARG A 1 777 ? 2.330   70.243  82.605  1.00 66.37  ?  758 ARG A CB  1 
ATOM   4634 C CG  . ARG A 1 777 ? 2.377   71.713  82.902  1.00 66.18  ?  758 ARG A CG  1 
ATOM   4635 C CD  . ARG A 1 777 ? 2.602   72.444  81.636  1.00 73.99  ?  758 ARG A CD  1 
ATOM   4636 N NE  . ARG A 1 777 ? 2.933   73.843  81.827  1.00 84.73  ?  758 ARG A NE  1 
ATOM   4637 C CZ  . ARG A 1 777 ? 2.893   74.738  80.842  1.00 82.78  ?  758 ARG A CZ  1 
ATOM   4638 N NH1 . ARG A 1 777 ? 2.487   74.349  79.635  1.00 80.34  ?  758 ARG A NH1 1 
ATOM   4639 N NH2 . ARG A 1 777 ? 3.180   76.006  81.049  1.00 82.25  ?  758 ARG A NH2 1 
ATOM   4640 N N   . GLY A 1 778 ? 0.339   67.501  81.191  1.00 62.82  ?  759 GLY A N   1 
ATOM   4641 C CA  . GLY A 1 778 ? 0.387   66.060  81.023  1.00 61.19  ?  759 GLY A CA  1 
ATOM   4642 C C   . GLY A 1 778 ? -0.930  65.406  81.423  1.00 61.56  ?  759 GLY A C   1 
ATOM   4643 O O   . GLY A 1 778 ? -1.918  66.071  81.705  1.00 58.88  ?  759 GLY A O   1 
ATOM   4644 N N   . SER A 1 779 ? -0.941  64.069  81.441  1.00 61.82  ?  760 SER A N   1 
ATOM   4645 C CA  . SER A 1 779 ? -2.180  63.353  81.725  1.00 60.70  ?  760 SER A CA  1 
ATOM   4646 C C   . SER A 1 779 ? -2.201  62.740  83.119  1.00 59.23  ?  760 SER A C   1 
ATOM   4647 O O   . SER A 1 779 ? -3.141  62.992  83.871  1.00 65.48  ?  760 SER A O   1 
ATOM   4648 C CB  . SER A 1 779 ? -2.447  62.282  80.667  1.00 64.39  ?  760 SER A CB  1 
ATOM   4649 O OG  . SER A 1 779 ? -1.455  61.275  80.718  1.00 72.52  ?  760 SER A OG  1 
ATOM   4650 N N   . TYR A 1 780 ? -1.217  61.925  83.488  1.00 60.65  ?  761 TYR A N   1 
ATOM   4651 C CA  . TYR A 1 780 ? -1.104  61.438  84.862  1.00 60.59  ?  761 TYR A CA  1 
ATOM   4652 C C   . TYR A 1 780 ? 0.306   60.911  85.089  1.00 62.89  ?  761 TYR A C   1 
ATOM   4653 O O   . TYR A 1 780 ? 1.155   60.935  84.193  1.00 63.07  ?  761 TYR A O   1 
ATOM   4654 C CB  . TYR A 1 780 ? -2.141  60.375  85.197  1.00 59.42  ?  761 TYR A CB  1 
ATOM   4655 C CG  . TYR A 1 780 ? -2.343  59.311  84.182  1.00 66.81  ?  761 TYR A CG  1 
ATOM   4656 C CD1 . TYR A 1 780 ? -1.565  58.150  84.198  1.00 70.17  ?  761 TYR A CD1 1 
ATOM   4657 C CD2 . TYR A 1 780 ? -3.345  59.426  83.226  1.00 68.51  ?  761 TYR A CD2 1 
ATOM   4658 C CE1 . TYR A 1 780 ? -1.767  57.136  83.279  1.00 68.70  ?  761 TYR A CE1 1 
ATOM   4659 C CE2 . TYR A 1 780 ? -3.545  58.421  82.293  1.00 73.20  ?  761 TYR A CE2 1 
ATOM   4660 C CZ  . TYR A 1 780 ? -2.753  57.283  82.327  1.00 71.54  ?  761 TYR A CZ  1 
ATOM   4661 O OH  . TYR A 1 780 ? -2.958  56.297  81.404  1.00 72.28  ?  761 TYR A OH  1 
ATOM   4662 N N   . SER A 1 781 ? 0.568   60.481  86.313  1.00 62.17  ?  762 SER A N   1 
ATOM   4663 C CA  . SER A 1 781 ? 1.932   60.158  86.688  1.00 65.07  ?  762 SER A CA  1 
ATOM   4664 C C   . SER A 1 781 ? 2.208   58.683  86.414  1.00 59.37  ?  762 SER A C   1 
ATOM   4665 O O   . SER A 1 781 ? 1.304   57.906  86.126  1.00 62.06  ?  762 SER A O   1 
ATOM   4666 C CB  . SER A 1 781 ? 2.188   60.505  88.154  1.00 60.03  ?  762 SER A CB  1 
ATOM   4667 O OG  . SER A 1 781 ? 1.288   59.812  88.995  1.00 60.08  ?  762 SER A OG  1 
ATOM   4668 N N   . TYR A 1 782 ? 3.486   58.320  86.489  1.00 56.28  ?  763 TYR A N   1 
ATOM   4669 C CA  . TYR A 1 782 ? 3.974   57.000  86.137  1.00 59.77  ?  763 TYR A CA  1 
ATOM   4670 C C   . TYR A 1 782 ? 5.259   56.798  86.914  1.00 60.29  ?  763 TYR A C   1 
ATOM   4671 O O   . TYR A 1 782 ? 5.897   57.760  87.334  1.00 66.56  ?  763 TYR A O   1 
ATOM   4672 C CB  . TYR A 1 782 ? 4.196   56.851  84.624  1.00 52.35  ?  763 TYR A CB  1 
ATOM   4673 C CG  . TYR A 1 782 ? 5.424   57.574  84.066  1.00 60.72  ?  763 TYR A CG  1 
ATOM   4674 C CD1 . TYR A 1 782 ? 6.722   57.048  84.223  1.00 61.53  ?  763 TYR A CD1 1 
ATOM   4675 C CD2 . TYR A 1 782 ? 5.293   58.764  83.338  1.00 57.39  ?  763 TYR A CD2 1 
ATOM   4676 C CE1 . TYR A 1 782 ? 7.844   57.716  83.684  1.00 62.51  ?  763 TYR A CE1 1 
ATOM   4677 C CE2 . TYR A 1 782 ? 6.401   59.423  82.815  1.00 56.67  ?  763 TYR A CE2 1 
ATOM   4678 C CZ  . TYR A 1 782 ? 7.674   58.907  82.990  1.00 59.97  ?  763 TYR A CZ  1 
ATOM   4679 O OH  . TYR A 1 782 ? 8.779   59.583  82.479  1.00 61.91  ?  763 TYR A OH  1 
ATOM   4680 N N   . VAL A 1 783 ? 5.643   55.547  87.137  1.00 63.25  ?  764 VAL A N   1 
ATOM   4681 C CA  . VAL A 1 783 ? 6.782   55.280  88.015  1.00 64.58  ?  764 VAL A CA  1 
ATOM   4682 C C   . VAL A 1 783 ? 8.027   55.310  87.138  1.00 63.32  ?  764 VAL A C   1 
ATOM   4683 O O   . VAL A 1 783 ? 8.406   54.315  86.531  1.00 68.73  ?  764 VAL A O   1 
ATOM   4684 C CB  . VAL A 1 783 ? 6.627   53.972  88.775  1.00 66.48  ?  764 VAL A CB  1 
ATOM   4685 C CG1 . VAL A 1 783 ? 7.708   53.881  89.843  1.00 64.39  ?  764 VAL A CG1 1 
ATOM   4686 C CG2 . VAL A 1 783 ? 5.228   53.885  89.385  1.00 63.55  ?  764 VAL A CG2 1 
ATOM   4687 N N   . ALA A 1 784 ? 8.658   56.479  87.061  1.00 65.25  ?  765 ALA A N   1 
ATOM   4688 C CA  . ALA A 1 784 ? 9.806   56.666  86.181  1.00 59.43  ?  765 ALA A CA  1 
ATOM   4689 C C   . ALA A 1 784 ? 10.977  55.808  86.622  1.00 62.88  ?  765 ALA A C   1 
ATOM   4690 O O   . ALA A 1 784 ? 11.142  55.505  87.807  1.00 61.81  ?  765 ALA A O   1 
ATOM   4691 C CB  . ALA A 1 784 ? 10.247  58.120  86.166  1.00 59.82  ?  765 ALA A CB  1 
ATOM   4692 N N   . ALA A 1 785 ? 11.791  55.412  85.648  1.00 63.68  ?  766 ALA A N   1 
ATOM   4693 C CA  . ALA A 1 785 ? 13.071  54.794  85.956  1.00 71.27  ?  766 ALA A CA  1 
ATOM   4694 C C   . ALA A 1 785 ? 13.877  55.718  86.860  1.00 68.86  ?  766 ALA A C   1 
ATOM   4695 O O   . ALA A 1 785 ? 13.918  56.931  86.653  1.00 73.92  ?  766 ALA A O   1 
ATOM   4696 C CB  . ALA A 1 785 ? 13.843  54.490  84.669  1.00 64.56  ?  766 ALA A CB  1 
ATOM   4697 N N   . GLY A 1 786 ? 14.509  55.149  87.877  1.00 71.18  ?  767 GLY A N   1 
ATOM   4698 C CA  . GLY A 1 786 ? 15.166  55.973  88.864  1.00 72.94  ?  767 GLY A CA  1 
ATOM   4699 C C   . GLY A 1 786 ? 14.253  56.543  89.931  1.00 73.02  ?  767 GLY A C   1 
ATOM   4700 O O   . GLY A 1 786 ? 14.752  57.137  90.897  1.00 72.70  ?  767 GLY A O   1 
ATOM   4701 N N   . SER A 1 787 ? 12.940  56.399  89.787  1.00 69.47  ?  768 SER A N   1 
ATOM   4702 C CA  . SER A 1 787 ? 11.986  56.724  90.831  1.00 64.47  ?  768 SER A CA  1 
ATOM   4703 C C   . SER A 1 787 ? 11.600  55.428  91.518  1.00 68.49  ?  768 SER A C   1 
ATOM   4704 O O   . SER A 1 787 ? 12.212  54.377  91.297  1.00 72.35  ?  768 SER A O   1 
ATOM   4705 C CB  . SER A 1 787 ? 10.765  57.460  90.251  1.00 69.85  ?  768 SER A CB  1 
ATOM   4706 O OG  . SER A 1 787 ? 9.857   57.918  91.244  1.00 65.34  ?  768 SER A OG  1 
ATOM   4707 N N   . SER A 1 788 ? 10.576  55.496  92.356  1.00 66.35  ?  769 SER A N   1 
ATOM   4708 C CA  . SER A 1 788 ? 10.096  54.354  93.117  1.00 64.90  ?  769 SER A CA  1 
ATOM   4709 C C   . SER A 1 788 ? 8.808   54.792  93.780  1.00 66.47  ?  769 SER A C   1 
ATOM   4710 O O   . SER A 1 788 ? 8.465   55.972  93.785  1.00 73.19  ?  769 SER A O   1 
ATOM   4711 C CB  . SER A 1 788 ? 11.082  53.890  94.178  1.00 63.80  ?  769 SER A CB  1 
ATOM   4712 O OG  . SER A 1 788 ? 11.018  54.741  95.296  1.00 71.10  ?  769 SER A OG  1 
ATOM   4713 N N   . GLY A 1 789 ? 8.101   53.834  94.351  1.00 68.68  ?  770 GLY A N   1 
ATOM   4714 C CA  . GLY A 1 789 ? 6.889   54.229  95.021  1.00 66.04  ?  770 GLY A CA  1 
ATOM   4715 C C   . GLY A 1 789 ? 7.124   55.026  96.273  1.00 65.98  ?  770 GLY A C   1 
ATOM   4716 O O   . GLY A 1 789 ? 6.176   55.624  96.794  1.00 69.91  ?  770 GLY A O   1 
ATOM   4717 N N   . ASN A 1 790 ? 8.357   55.054  96.778  1.00 66.00  ?  771 ASN A N   1 
ATOM   4718 C CA  . ASN A 1 790 ? 8.612   55.881  97.948  1.00 68.01  ?  771 ASN A CA  1 
ATOM   4719 C C   . ASN A 1 790 ? 8.420   57.373  97.642  1.00 69.79  ?  771 ASN A C   1 
ATOM   4720 O O   . ASN A 1 790 ? 7.991   58.131  98.520  1.00 65.97  ?  771 ASN A O   1 
ATOM   4721 C CB  . ASN A 1 790 ? 10.014  55.632  98.488  1.00 71.31  ?  771 ASN A CB  1 
ATOM   4722 C CG  . ASN A 1 790 ? 10.156  56.120  99.909  1.00 91.92  ?  771 ASN A CG  1 
ATOM   4723 O OD1 . ASN A 1 790 ? 10.960  57.032  100.210 1.00 81.54  ?  771 ASN A OD1 1 
ATOM   4724 N ND2 . ASN A 1 790 ? 9.389   55.496  100.816 1.00 96.87  ?  771 ASN A ND2 1 
ATOM   4725 N N   . ASP A 1 791 ? 8.738   57.809  96.411  1.00 65.42  ?  772 ASP A N   1 
ATOM   4726 C CA  . ASP A 1 791 ? 8.508   59.189  96.005  1.00 53.99  ?  772 ASP A CA  1 
ATOM   4727 C C   . ASP A 1 791 ? 7.046   59.585  96.152  1.00 62.50  ?  772 ASP A C   1 
ATOM   4728 O O   . ASP A 1 791 ? 6.734   60.737  96.482  1.00 66.26  ?  772 ASP A O   1 
ATOM   4729 C CB  . ASP A 1 791 ? 8.954   59.385  94.566  1.00 56.09  ?  772 ASP A CB  1 
ATOM   4730 C CG  . ASP A 1 791 ? 10.434  59.549  94.449  1.00 59.93  ?  772 ASP A CG  1 
ATOM   4731 O OD1 . ASP A 1 791 ? 11.074  59.831  95.476  1.00 62.02  ?  772 ASP A OD1 1 
ATOM   4732 O OD2 . ASP A 1 791 ? 10.967  59.401  93.333  1.00 63.30  ?  772 ASP A OD2 1 
ATOM   4733 N N   . TYR A 1 792 ? 6.128   58.656  95.907  1.00 64.51  ?  773 TYR A N   1 
ATOM   4734 C CA  . TYR A 1 792 ? 4.720   58.994  96.051  1.00 65.61  ?  773 TYR A CA  1 
ATOM   4735 C C   . TYR A 1 792 ? 4.349   59.305  97.510  1.00 66.55  ?  773 TYR A C   1 
ATOM   4736 O O   . TYR A 1 792 ? 3.352   59.986  97.752  1.00 70.51  ?  773 TYR A O   1 
ATOM   4737 C CB  . TYR A 1 792 ? 3.863   57.850  95.509  1.00 63.11  ?  773 TYR A CB  1 
ATOM   4738 C CG  . TYR A 1 792 ? 3.801   57.702  93.993  1.00 72.05  ?  773 TYR A CG  1 
ATOM   4739 C CD1 . TYR A 1 792 ? 2.790   58.310  93.258  1.00 71.50  ?  773 TYR A CD1 1 
ATOM   4740 C CD2 . TYR A 1 792 ? 4.720   56.902  93.299  1.00 69.00  ?  773 TYR A CD2 1 
ATOM   4741 C CE1 . TYR A 1 792 ? 2.697   58.142  91.866  1.00 68.40  ?  773 TYR A CE1 1 
ATOM   4742 C CE2 . TYR A 1 792 ? 4.637   56.734  91.910  1.00 68.91  ?  773 TYR A CE2 1 
ATOM   4743 C CZ  . TYR A 1 792 ? 3.623   57.355  91.196  1.00 73.08  ?  773 TYR A CZ  1 
ATOM   4744 O OH  . TYR A 1 792 ? 3.538   57.197  89.807  1.00 78.23  ?  773 TYR A OH  1 
ATOM   4745 N N   . ASP A 1 793 ? 5.117   58.817  98.487  1.00 63.15  ?  774 ASP A N   1 
ATOM   4746 C CA  . ASP A 1 793 ? 4.839   59.141  99.881  1.00 62.50  ?  774 ASP A CA  1 
ATOM   4747 C C   . ASP A 1 793 ? 5.478   60.462  100.251 1.00 64.71  ?  774 ASP A C   1 
ATOM   4748 O O   . ASP A 1 793 ? 4.883   61.263  100.979 1.00 66.28  ?  774 ASP A O   1 
ATOM   4749 C CB  . ASP A 1 793 ? 5.346   58.034  100.816 1.00 61.90  ?  774 ASP A CB  1 
ATOM   4750 C CG  . ASP A 1 793 ? 4.423   56.802  100.839 1.00 71.81  ?  774 ASP A CG  1 
ATOM   4751 O OD1 . ASP A 1 793 ? 4.895   55.682  101.178 1.00 73.35  ?  774 ASP A OD1 1 
ATOM   4752 O OD2 . ASP A 1 793 ? 3.222   56.960  100.490 1.00 77.80  ?  774 ASP A OD2 1 
ATOM   4753 N N   . LEU A 1 794 ? 6.697   60.677  99.763  1.00 62.56  ?  775 LEU A N   1 
ATOM   4754 C CA  . LEU A 1 794 ? 7.323   61.986  99.815  1.00 58.74  ?  775 LEU A CA  1 
ATOM   4755 C C   . LEU A 1 794 ? 6.390   63.068  99.292  1.00 62.15  ?  775 LEU A C   1 
ATOM   4756 O O   . LEU A 1 794 ? 6.217   64.102  99.939  1.00 67.35  ?  775 LEU A O   1 
ATOM   4757 C CB  . LEU A 1 794 ? 8.621   61.959  99.026  1.00 59.08  ?  775 LEU A CB  1 
ATOM   4758 C CG  . LEU A 1 794 ? 9.724   61.194  99.750  1.00 56.80  ?  775 LEU A CG  1 
ATOM   4759 C CD1 . LEU A 1 794 ? 10.948  61.212  98.896  1.00 63.13  ?  775 LEU A CD1 1 
ATOM   4760 C CD2 . LEU A 1 794 ? 10.032  61.808  101.107 1.00 54.72  ?  775 LEU A CD2 1 
ATOM   4761 N N   . MET A 1 795 ? 5.759   62.853  98.133  1.00 60.68  ?  776 MET A N   1 
ATOM   4762 C CA  . MET A 1 795 ? 4.820   63.866  97.660  1.00 57.52  ?  776 MET A CA  1 
ATOM   4763 C C   . MET A 1 795 ? 3.722   64.151  98.663  1.00 65.33  ?  776 MET A C   1 
ATOM   4764 O O   . MET A 1 795 ? 3.171   65.256  98.660  1.00 72.10  ?  776 MET A O   1 
ATOM   4765 C CB  . MET A 1 795 ? 4.146   63.477  96.358  1.00 64.53  ?  776 MET A CB  1 
ATOM   4766 C CG  . MET A 1 795 ? 5.071   63.379  95.178  1.00 70.03  ?  776 MET A CG  1 
ATOM   4767 S SD  . MET A 1 795 ? 5.910   64.917  94.854  1.00 74.72  ?  776 MET A SD  1 
ATOM   4768 C CE  . MET A 1 795 ? 4.501   66.011  94.743  1.00 67.93  ?  776 MET A CE  1 
ATOM   4769 N N   . ALA A 1 796 ? 3.400   63.201  99.529  1.00 63.46  ?  777 ALA A N   1 
ATOM   4770 C CA  . ALA A 1 796 ? 2.275   63.383  100.426 1.00 63.65  ?  777 ALA A CA  1 
ATOM   4771 C C   . ALA A 1 796 ? 2.636   64.067  101.747 1.00 61.64  ?  777 ALA A C   1 
ATOM   4772 O O   . ALA A 1 796 ? 1.721   64.488  102.470 1.00 66.39  ?  777 ALA A O   1 
ATOM   4773 C CB  . ALA A 1 796 ? 1.619   62.024  100.692 1.00 57.06  ?  777 ALA A CB  1 
ATOM   4774 N N   . GLN A 1 797 ? 3.926   64.200  102.094 1.00 55.68  ?  778 GLN A N   1 
ATOM   4775 C CA  . GLN A 1 797 ? 4.213   64.683  103.443 1.00 60.13  ?  778 GLN A CA  1 
ATOM   4776 C C   . GLN A 1 797 ? 3.970   66.188  103.518 1.00 66.08  ?  778 GLN A C   1 
ATOM   4777 O O   . GLN A 1 797 ? 4.447   66.937  102.651 1.00 63.51  ?  778 GLN A O   1 
ATOM   4778 C CB  . GLN A 1 797 ? 5.643   64.341  103.888 1.00 64.08  ?  778 GLN A CB  1 
ATOM   4779 C CG  . GLN A 1 797 ? 5.892   62.844  104.244 1.00 76.75  ?  778 GLN A CG  1 
ATOM   4780 C CD  . GLN A 1 797 ? 4.742   62.168  105.054 1.00 90.70  ?  778 GLN A CD  1 
ATOM   4781 O OE1 . GLN A 1 797 ? 3.919   61.410  104.482 1.00 80.43  ?  778 GLN A OE1 1 
ATOM   4782 N NE2 . GLN A 1 797 ? 4.695   62.427  106.378 1.00 87.63  ?  778 GLN A NE2 1 
ATOM   4783 N N   . PRO A 1 798 ? 3.208   66.662  104.502 1.00 62.83  ?  779 PRO A N   1 
ATOM   4784 C CA  . PRO A 1 798 ? 3.004   68.107  104.643 1.00 63.24  ?  779 PRO A CA  1 
ATOM   4785 C C   . PRO A 1 798 ? 4.318   68.832  104.889 1.00 61.96  ?  779 PRO A C   1 
ATOM   4786 O O   . PRO A 1 798 ? 5.323   68.234  105.277 1.00 64.56  ?  779 PRO A O   1 
ATOM   4787 C CB  . PRO A 1 798 ? 2.074   68.218  105.857 1.00 59.90  ?  779 PRO A CB  1 
ATOM   4788 C CG  . PRO A 1 798 ? 2.270   66.938  106.576 1.00 55.49  ?  779 PRO A CG  1 
ATOM   4789 C CD  . PRO A 1 798 ? 2.477   65.910  105.526 1.00 61.58  ?  779 PRO A CD  1 
ATOM   4790 N N   . ILE A 1 799 ? 4.306   70.146  104.635 1.00 56.45  ?  780 ILE A N   1 
ATOM   4791 C CA  . ILE A 1 799 ? 5.452   71.005  104.915 1.00 62.22  ?  780 ILE A CA  1 
ATOM   4792 C C   . ILE A 1 799 ? 5.188   71.833  106.168 1.00 65.47  ?  780 ILE A C   1 
ATOM   4793 O O   . ILE A 1 799 ? 4.081   72.343  106.390 1.00 58.83  ?  780 ILE A O   1 
ATOM   4794 C CB  . ILE A 1 799 ? 5.763   71.912  103.720 1.00 64.62  ?  780 ILE A CB  1 
ATOM   4795 C CG1 . ILE A 1 799 ? 5.751   71.095  102.436 1.00 58.76  ?  780 ILE A CG1 1 
ATOM   4796 C CG2 . ILE A 1 799 ? 7.135   72.555  103.916 1.00 60.18  ?  780 ILE A CG2 1 
ATOM   4797 C CD1 . ILE A 1 799 ? 6.907   70.181  102.349 1.00 58.49  ?  780 ILE A CD1 1 
ATOM   4798 N N   . THR A 1 800 ? 6.207   71.947  107.007 1.00 70.88  ?  781 THR A N   1 
ATOM   4799 C CA  . THR A 1 800 ? 6.103   72.736  108.221 1.00 69.54  ?  781 THR A CA  1 
ATOM   4800 C C   . THR A 1 800 ? 7.093   73.884  108.136 1.00 70.16  ?  781 THR A C   1 
ATOM   4801 O O   . THR A 1 800 ? 8.300   73.640  107.974 1.00 72.20  ?  781 THR A O   1 
ATOM   4802 C CB  . THR A 1 800 ? 6.369   71.877  109.462 1.00 70.27  ?  781 THR A CB  1 
ATOM   4803 O OG1 . THR A 1 800 ? 5.235   71.026  109.713 1.00 74.04  ?  781 THR A OG1 1 
ATOM   4804 C CG2 . THR A 1 800 ? 6.605   72.739  110.669 1.00 76.03  ?  781 THR A CG2 1 
ATOM   4805 N N   . PRO A 1 801 ? 6.630   75.132  108.224 1.00 69.42  ?  782 PRO A N   1 
ATOM   4806 C CA  . PRO A 1 801 ? 7.540   76.278  108.104 1.00 65.38  ?  782 PRO A CA  1 
ATOM   4807 C C   . PRO A 1 801 ? 8.414   76.395  109.338 1.00 72.82  ?  782 PRO A C   1 
ATOM   4808 O O   . PRO A 1 801 ? 8.102   75.840  110.392 1.00 79.62  ?  782 PRO A O   1 
ATOM   4809 C CB  . PRO A 1 801 ? 6.587   77.467  108.000 1.00 65.42  ?  782 PRO A CB  1 
ATOM   4810 C CG  . PRO A 1 801 ? 5.404   77.033  108.834 1.00 69.02  ?  782 PRO A CG  1 
ATOM   4811 C CD  . PRO A 1 801 ? 5.274   75.537  108.650 1.00 68.30  ?  782 PRO A CD  1 
ATOM   4812 N N   . GLY A 1 802 ? 9.528   77.117  109.202 1.00 74.74  ?  783 GLY A N   1 
ATOM   4813 C CA  . GLY A 1 802 ? 10.369  77.424  110.346 1.00 72.78  ?  783 GLY A CA  1 
ATOM   4814 C C   . GLY A 1 802 ? 9.689   78.381  111.310 1.00 76.85  ?  783 GLY A C   1 
ATOM   4815 O O   . GLY A 1 802 ? 8.659   78.981  110.985 1.00 82.54  ?  783 GLY A O   1 
ATOM   4816 N N   . PRO A 1 803 ? 10.241  78.560  112.512 1.00 84.81  ?  784 PRO A N   1 
ATOM   4817 C CA  . PRO A 1 803 ? 9.637   79.520  113.452 1.00 84.26  ?  784 PRO A CA  1 
ATOM   4818 C C   . PRO A 1 803 ? 9.828   80.966  112.993 1.00 85.51  ?  784 PRO A C   1 
ATOM   4819 O O   . PRO A 1 803 ? 10.837  81.322  112.376 1.00 81.11  ?  784 PRO A O   1 
ATOM   4820 C CB  . PRO A 1 803 ? 10.381  79.250  114.764 1.00 81.75  ?  784 PRO A CB  1 
ATOM   4821 C CG  . PRO A 1 803 ? 11.706  78.698  114.340 1.00 80.01  ?  784 PRO A CG  1 
ATOM   4822 C CD  . PRO A 1 803 ? 11.483  77.962  113.041 1.00 78.02  ?  784 PRO A CD  1 
ATOM   4823 N N   . SER A 1 804 ? 8.829   81.807  113.297 1.00 90.69  ?  785 SER A N   1 
ATOM   4824 C CA  . SER A 1 804 ? 8.984   83.248  113.078 1.00 93.50  ?  785 SER A CA  1 
ATOM   4825 C C   . SER A 1 804 ? 10.045  83.825  114.010 1.00 97.46  ?  785 SER A C   1 
ATOM   4826 O O   . SER A 1 804 ? 11.075  84.344  113.557 1.00 93.55  ?  785 SER A O   1 
ATOM   4827 C CB  . SER A 1 804 ? 7.653   83.985  113.278 1.00 89.49  ?  785 SER A CB  1 
ATOM   4828 O OG  . SER A 1 804 ? 6.725   83.775  112.225 1.00 80.77  ?  785 SER A OG  1 
ATOM   4829 N N   . ILE A 1 805 ? 9.811   83.732  115.321 1.00 97.56  ?  786 ILE A N   1 
ATOM   4830 C CA  . ILE A 1 805 ? 10.719  84.287  116.320 1.00 100.52 ?  786 ILE A CA  1 
ATOM   4831 C C   . ILE A 1 805 ? 11.752  83.184  116.545 1.00 102.20 ?  786 ILE A C   1 
ATOM   4832 O O   . ILE A 1 805 ? 11.348  82.052  116.865 1.00 102.56 ?  786 ILE A O   1 
ATOM   4833 C CB  . ILE A 1 805 ? 9.997   84.626  117.640 1.00 103.02 ?  786 ILE A CB  1 
ATOM   4834 C CG1 . ILE A 1 805 ? 8.711   85.433  117.422 1.00 100.79 ?  786 ILE A CG1 1 
ATOM   4835 C CG2 . ILE A 1 805 ? 10.891  85.512  118.493 1.00 95.23  ?  786 ILE A CG2 1 
ATOM   4836 C CD1 . ILE A 1 805 ? 7.438   84.544  117.305 1.00 97.07  ?  786 ILE A CD1 1 
ATOM   4837 N N   . PRO A 1 806 ? 13.059  83.415  116.359 1.00 106.22 ?  787 PRO A N   1 
ATOM   4838 C CA  . PRO A 1 806 ? 14.032  82.358  116.677 1.00 109.22 ?  787 PRO A CA  1 
ATOM   4839 C C   . PRO A 1 806 ? 13.914  81.896  118.125 1.00 105.60 ?  787 PRO A C   1 
ATOM   4840 O O   . PRO A 1 806 ? 13.735  82.702  119.044 1.00 93.99  ?  787 PRO A O   1 
ATOM   4841 C CB  . PRO A 1 806 ? 15.392  83.013  116.395 1.00 104.96 ?  787 PRO A CB  1 
ATOM   4842 C CG  . PRO A 1 806 ? 15.124  84.158  115.530 1.00 107.10 ?  787 PRO A CG  1 
ATOM   4843 C CD  . PRO A 1 806 ? 13.629  84.406  115.436 1.00 108.19 ?  787 PRO A CD  1 
ATOM   4844 N N   . GLY A 1 807 ? 13.987  80.586  118.313 1.00 102.36 ?  788 GLY A N   1 
ATOM   4845 C CA  . GLY A 1 807 ? 13.852  80.021  119.662 1.00 100.07 ?  788 GLY A CA  1 
ATOM   4846 C C   . GLY A 1 807 ? 12.400  79.821  120.012 1.00 94.51  ?  788 GLY A C   1 
ATOM   4847 O O   . GLY A 1 807 ? 12.109  79.500  121.144 1.00 92.36  ?  788 GLY A O   1 
ATOM   4848 N N   . ALA A 1 808 ? 11.512  80.068  119.072 1.00 91.79  ?  789 ALA A N   1 
ATOM   4849 C CA  . ALA A 1 808 ? 10.099  79.823  119.387 1.00 88.26  ?  789 ALA A CA  1 
ATOM   4850 C C   . ALA A 1 808 ? 9.832   78.345  119.153 1.00 94.15  ?  789 ALA A C   1 
ATOM   4851 O O   . ALA A 1 808 ? 10.543  77.728  118.387 1.00 91.56  ?  789 ALA A O   1 
ATOM   4852 C CB  . ALA A 1 808 ? 9.241   80.682  118.523 1.00 88.44  ?  789 ALA A CB  1 
ATOM   4853 N N   . PRO A 1 809 ? 8.788   77.759  119.744 1.00 89.34  ?  790 PRO A N   1 
ATOM   4854 C CA  . PRO A 1 809 ? 8.537   76.356  119.602 1.00 87.88  ?  790 PRO A CA  1 
ATOM   4855 C C   . PRO A 1 809 ? 8.208   75.962  118.167 1.00 94.25  ?  790 PRO A C   1 
ATOM   4856 O O   . PRO A 1 809 ? 7.627   76.723  117.472 1.00 91.67  ?  790 PRO A O   1 
ATOM   4857 C CB  . PRO A 1 809 ? 7.287   76.157  120.442 1.00 86.38  ?  790 PRO A CB  1 
ATOM   4858 C CG  . PRO A 1 809 ? 6.627   77.477  120.382 1.00 89.60  ?  790 PRO A CG  1 
ATOM   4859 C CD  . PRO A 1 809 ? 7.785   78.428  120.518 1.00 95.50  ?  790 PRO A CD  1 
ATOM   4860 N N   . GLN A 1 810 ? 8.578   74.738  117.815 1.00 94.11  ?  791 GLN A N   1 
ATOM   4861 C CA  . GLN A 1 810 ? 8.337   74.170  116.474 1.00 94.46  ?  791 GLN A CA  1 
ATOM   4862 C C   . GLN A 1 810 ? 6.866   74.322  116.126 1.00 92.42  ?  791 GLN A C   1 
ATOM   4863 O O   . GLN A 1 810 ? 6.032   73.858  116.879 1.00 90.83  ?  791 GLN A O   1 
ATOM   4864 C CB  . GLN A 1 810 ? 8.663   72.687  116.495 1.00 87.53  ?  791 GLN A CB  1 
ATOM   4865 C CG  . GLN A 1 810 ? 8.189   71.977  115.250 1.00 92.45  ?  791 GLN A CG  1 
ATOM   4866 C CD  . GLN A 1 810 ? 9.372   71.759  114.352 1.00 100.61 ?  791 GLN A CD  1 
ATOM   4867 O OE1 . GLN A 1 810 ? 10.470  72.225  114.627 1.00 104.77 ?  791 GLN A OE1 1 
ATOM   4868 N NE2 . GLN A 1 810 ? 9.158   71.030  113.276 1.00 99.72  ?  791 GLN A NE2 1 
ATOM   4869 N N   . PRO A 1 811 ? 6.517   74.917  114.983 1.00 90.24  ?  792 PRO A N   1 
ATOM   4870 C CA  . PRO A 1 811 ? 5.131   75.087  114.656 1.00 89.72  ?  792 PRO A CA  1 
ATOM   4871 C C   . PRO A 1 811 ? 4.481   73.850  114.039 1.00 85.34  ?  792 PRO A C   1 
ATOM   4872 O O   . PRO A 1 811 ? 5.098   72.866  113.864 1.00 81.86  ?  792 PRO A O   1 
ATOM   4873 C CB  . PRO A 1 811 ? 5.197   76.182  113.601 1.00 78.32  ?  792 PRO A CB  1 
ATOM   4874 C CG  . PRO A 1 811 ? 6.490   75.914  112.913 1.00 79.05  ?  792 PRO A CG  1 
ATOM   4875 C CD  . PRO A 1 811 ? 7.427   75.466  114.004 1.00 82.21  ?  792 PRO A CD  1 
ATOM   4876 N N   . ILE A 1 812 ? 3.215   74.027  113.704 1.00 82.67  ?  793 ILE A N   1 
ATOM   4877 C CA  . ILE A 1 812 ? 2.287   73.071  113.063 1.00 74.41  ?  793 ILE A CA  1 
ATOM   4878 C C   . ILE A 1 812 ? 2.620   73.005  111.580 1.00 73.34  ?  793 ILE A C   1 
ATOM   4879 O O   . ILE A 1 812 ? 3.257   73.894  111.081 1.00 73.36  ?  793 ILE A O   1 
ATOM   4880 C CB  . ILE A 1 812 ? 0.912   73.715  113.254 1.00 76.27  ?  793 ILE A CB  1 
ATOM   4881 C CG1 . ILE A 1 812 ? 0.723   74.117  114.709 1.00 84.86  ?  793 ILE A CG1 1 
ATOM   4882 C CG2 . ILE A 1 812 ? -0.217  72.830  112.789 1.00 84.09  ?  793 ILE A CG2 1 
ATOM   4883 C CD1 . ILE A 1 812 ? 0.728   75.593  114.932 1.00 91.64  ?  793 ILE A CD1 1 
ATOM   4884 N N   . PRO A 1 813 ? 2.219   71.964  110.843 1.00 81.10  ?  794 PRO A N   1 
ATOM   4885 C CA  . PRO A 1 813 ? 2.440   71.921  109.421 1.00 73.84  ?  794 PRO A CA  1 
ATOM   4886 C C   . PRO A 1 813 ? 1.368   72.815  108.795 1.00 68.95  ?  794 PRO A C   1 
ATOM   4887 O O   . PRO A 1 813 ? 0.306   72.867  109.296 1.00 67.83  ?  794 PRO A O   1 
ATOM   4888 C CB  . PRO A 1 813 ? 2.179   70.454  109.131 1.00 60.77  ?  794 PRO A CB  1 
ATOM   4889 C CG  . PRO A 1 813 ? 2.288   69.808  110.455 1.00 64.23  ?  794 PRO A CG  1 
ATOM   4890 C CD  . PRO A 1 813 ? 1.560   70.784  111.328 1.00 74.84  ?  794 PRO A CD  1 
ATOM   4891 N N   . ARG A 1 814 ? 1.670   73.466  107.684 1.00 66.54  ?  795 ARG A N   1 
ATOM   4892 C CA  . ARG A 1 814 ? 0.687   74.404  107.109 1.00 66.44  ?  795 ARG A CA  1 
ATOM   4893 C C   . ARG A 1 814 ? 0.401   74.087  105.650 1.00 61.84  ?  795 ARG A C   1 
ATOM   4894 O O   . ARG A 1 814 ? -0.658  74.421  105.207 1.00 62.27  ?  795 ARG A O   1 
ATOM   4895 C CB  . ARG A 1 814 ? 1.258   75.813  107.210 1.00 59.75  ?  795 ARG A CB  1 
ATOM   4896 C CG  . ARG A 1 814 ? 1.493   76.293  108.628 1.00 63.15  ?  795 ARG A CG  1 
ATOM   4897 C CD  . ARG A 1 814 ? 0.321   77.093  109.113 1.00 61.53  ?  795 ARG A CD  1 
ATOM   4898 N NE  . ARG A 1 814 ? 0.529   77.505  110.473 1.00 63.69  ?  795 ARG A NE  1 
ATOM   4899 C CZ  . ARG A 1 814 ? -0.431  77.873  111.280 1.00 63.85  ?  795 ARG A CZ  1 
ATOM   4900 N NH1 . ARG A 1 814 ? -1.673  77.871  110.870 1.00 63.85  ?  795 ARG A NH1 1 
ATOM   4901 N NH2 . ARG A 1 814 ? -0.158  78.246  112.501 1.00 67.27  ?  795 ARG A NH2 1 
ATOM   4902 N N   . LEU A 1 815 ? 1.334   73.462  104.953 1.00 58.05  ?  796 LEU A N   1 
ATOM   4903 C CA  . LEU A 1 815 ? 1.175   73.144  103.516 1.00 63.63  ?  796 LEU A CA  1 
ATOM   4904 C C   . LEU A 1 815 ? 0.922   71.651  103.342 1.00 62.85  ?  796 LEU A C   1 
ATOM   4905 O O   . LEU A 1 815 ? 1.760   70.891  103.714 1.00 58.61  ?  796 LEU A O   1 
ATOM   4906 C CB  . LEU A 1 815 ? 2.470   73.564  102.831 1.00 62.31  ?  796 LEU A CB  1 
ATOM   4907 C CG  . LEU A 1 815 ? 2.456   73.585  101.318 1.00 60.28  ?  796 LEU A CG  1 
ATOM   4908 C CD1 . LEU A 1 815 ? 1.238   74.297  100.828 1.00 61.13  ?  796 LEU A CD1 1 
ATOM   4909 C CD2 . LEU A 1 815 ? 3.688   74.264  100.800 1.00 51.54  ?  796 LEU A CD2 1 
ATOM   4910 N N   . PHE A 1 816 ? -0.214  71.284  102.765 1.00 62.23  ?  797 PHE A N   1 
ATOM   4911 C CA  . PHE A 1 816 ? -0.610  69.891  102.568 1.00 60.11  ?  797 PHE A CA  1 
ATOM   4912 C C   . PHE A 1 816 ? -0.785  69.563  101.080 1.00 59.33  ?  797 PHE A C   1 
ATOM   4913 O O   . PHE A 1 816 ? -1.116  70.434  100.271 1.00 61.92  ?  797 PHE A O   1 
ATOM   4914 C CB  . PHE A 1 816 ? -1.906  69.595  103.324 1.00 57.52  ?  797 PHE A CB  1 
ATOM   4915 C CG  . PHE A 1 816 ? -1.802  69.840  104.792 1.00 63.10  ?  797 PHE A CG  1 
ATOM   4916 C CD1 . PHE A 1 816 ? -1.860  71.142  105.307 1.00 67.38  ?  797 PHE A CD1 1 
ATOM   4917 C CD2 . PHE A 1 816 ? -1.610  68.788  105.666 1.00 60.68  ?  797 PHE A CD2 1 
ATOM   4918 C CE1 . PHE A 1 816 ? -1.741  71.383  106.679 1.00 59.06  ?  797 PHE A CE1 1 
ATOM   4919 C CE2 . PHE A 1 816 ? -1.487  69.010  107.028 1.00 62.55  ?  797 PHE A CE2 1 
ATOM   4920 C CZ  . PHE A 1 816 ? -1.556  70.309  107.537 1.00 64.65  ?  797 PHE A CZ  1 
ATOM   4921 N N   . PHE A 1 817 ? -0.566  68.294  100.712 1.00 65.36  ?  798 PHE A N   1 
ATOM   4922 C CA  . PHE A 1 817 ? -0.612  67.888  99.304  1.00 63.14  ?  798 PHE A CA  1 
ATOM   4923 C C   . PHE A 1 817 ? -1.558  66.729  99.091  1.00 60.81  ?  798 PHE A C   1 
ATOM   4924 O O   . PHE A 1 817 ? -1.610  65.797  99.897  1.00 59.33  ?  798 PHE A O   1 
ATOM   4925 C CB  . PHE A 1 817 ? 0.744   67.487  98.789  1.00 57.33  ?  798 PHE A CB  1 
ATOM   4926 C CG  . PHE A 1 817 ? 1.711   68.600  98.794  1.00 64.63  ?  798 PHE A CG  1 
ATOM   4927 C CD1 . PHE A 1 817 ? 2.388   68.928  99.945  1.00 57.96  ?  798 PHE A CD1 1 
ATOM   4928 C CD2 . PHE A 1 817 ? 1.926   69.346  97.656  1.00 66.26  ?  798 PHE A CD2 1 
ATOM   4929 C CE1 . PHE A 1 817 ? 3.284   69.971  99.946  1.00 58.90  ?  798 PHE A CE1 1 
ATOM   4930 C CE2 . PHE A 1 817 ? 2.814   70.390  97.660  1.00 58.76  ?  798 PHE A CE2 1 
ATOM   4931 C CZ  . PHE A 1 817 ? 3.504   70.688  98.811  1.00 57.42  ?  798 PHE A CZ  1 
ATOM   4932 N N   . ALA A 1 818 ? -2.288  66.786  97.986  1.00 58.27  ?  799 ALA A N   1 
ATOM   4933 C CA  . ALA A 1 818 ? -3.129  65.671  97.591  1.00 60.02  ?  799 ALA A CA  1 
ATOM   4934 C C   . ALA A 1 818 ? -3.197  65.651  96.072  1.00 59.30  ?  799 ALA A C   1 
ATOM   4935 O O   . ALA A 1 818 ? -2.543  66.448  95.393  1.00 58.76  ?  799 ALA A O   1 
ATOM   4936 C CB  . ALA A 1 818 ? -4.508  65.750  98.252  1.00 59.11  ?  799 ALA A CB  1 
ATOM   4937 N N   . GLY A 1 819 ? -3.951  64.703  95.534  1.00 66.08  ?  800 GLY A N   1 
ATOM   4938 C CA  . GLY A 1 819 ? -3.971  64.473  94.099  1.00 71.38  ?  800 GLY A CA  1 
ATOM   4939 C C   . GLY A 1 819 ? -3.333  63.142  93.717  1.00 61.14  ?  800 GLY A C   1 
ATOM   4940 O O   . GLY A 1 819 ? -2.650  62.483  94.511  1.00 56.83  ?  800 GLY A O   1 
ATOM   4941 N N   . GLU A 1 820 ? -3.555  62.773  92.439  1.00 59.03  ?  801 GLU A N   1 
ATOM   4942 C CA  . GLU A 1 820 ? -3.253  61.412  91.987  1.00 58.80  ?  801 GLU A CA  1 
ATOM   4943 C C   . GLU A 1 820 ? -1.783  61.056  92.163  1.00 59.33  ?  801 GLU A C   1 
ATOM   4944 O O   . GLU A 1 820 ? -1.461  59.891  92.421  1.00 57.96  ?  801 GLU A O   1 
ATOM   4945 C CB  . GLU A 1 820 ? -3.673  61.199  90.529  1.00 56.60  ?  801 GLU A CB  1 
ATOM   4946 C CG  . GLU A 1 820 ? -3.040  62.090  89.491  1.00 59.81  ?  801 GLU A CG  1 
ATOM   4947 C CD  . GLU A 1 820 ? -1.742  61.543  88.933  1.00 62.64  ?  801 GLU A CD  1 
ATOM   4948 O OE1 . GLU A 1 820 ? -1.357  60.417  89.312  1.00 60.33  ?  801 GLU A OE1 1 
ATOM   4949 O OE2 . GLU A 1 820 ? -1.107  62.225  88.088  1.00 64.55  ?  801 GLU A OE2 1 
ATOM   4950 N N   . HIS A 1 821 ? -0.889  62.030  92.064  1.00 55.71  ?  802 HIS A N   1 
ATOM   4951 C CA  . HIS A 1 821 ? 0.539   61.803  92.225  1.00 55.03  ?  802 HIS A CA  1 
ATOM   4952 C C   . HIS A 1 821 ? 0.966   61.678  93.691  1.00 58.39  ?  802 HIS A C   1 
ATOM   4953 O O   . HIS A 1 821 ? 2.168   61.587  93.951  1.00 62.84  ?  802 HIS A O   1 
ATOM   4954 C CB  . HIS A 1 821 ? 1.306   62.941  91.548  1.00 55.29  ?  802 HIS A CB  1 
ATOM   4955 C CG  . HIS A 1 821 ? 0.985   64.271  92.155  1.00 64.42  ?  802 HIS A CG  1 
ATOM   4956 N ND1 . HIS A 1 821 ? -0.265  64.849  92.051  1.00 63.84  ?  802 HIS A ND1 1 
ATOM   4957 C CD2 . HIS A 1 821 ? 1.710   65.087  92.952  1.00 55.18  ?  802 HIS A CD2 1 
ATOM   4958 C CE1 . HIS A 1 821 ? -0.295  65.955  92.758  1.00 54.94  ?  802 HIS A CE1 1 
ATOM   4959 N NE2 . HIS A 1 821 ? 0.893   66.127  93.307  1.00 60.08  ?  802 HIS A NE2 1 
ATOM   4960 N N   . THR A 1 822 ? 0.032   61.653  94.655  1.00 60.02  ?  803 THR A N   1 
ATOM   4961 C CA  . THR A 1 822 ? 0.376   61.585  96.082  1.00 59.93  ?  803 THR A CA  1 
ATOM   4962 C C   . THR A 1 822 ? -0.108  60.327  96.799  1.00 62.41  ?  803 THR A C   1 
ATOM   4963 O O   . THR A 1 822 ? 0.016   60.253  98.025  1.00 69.56  ?  803 THR A O   1 
ATOM   4964 C CB  . THR A 1 822 ? -0.194  62.806  96.854  1.00 62.40  ?  803 THR A CB  1 
ATOM   4965 O OG1 . THR A 1 822 ? -1.630  62.843  96.747  1.00 56.45  ?  803 THR A OG1 1 
ATOM   4966 C CG2 . THR A 1 822 ? 0.387   64.131  96.319  1.00 64.41  ?  803 THR A CG2 1 
ATOM   4967 N N   . ILE A 1 823 ? -0.702  59.358  96.116  1.00 61.37  ?  804 ILE A N   1 
ATOM   4968 C CA  . ILE A 1 823 ? -1.247  58.183  96.794  1.00 55.32  ?  804 ILE A CA  1 
ATOM   4969 C C   . ILE A 1 823 ? -0.540  56.949  96.216  1.00 60.89  ?  804 ILE A C   1 
ATOM   4970 O O   . ILE A 1 823 ? -0.799  56.519  95.084  1.00 62.50  ?  804 ILE A O   1 
ATOM   4971 C CB  . ILE A 1 823 ? -2.781  58.124  96.686  1.00 52.42  ?  804 ILE A CB  1 
ATOM   4972 C CG1 . ILE A 1 823 ? -3.358  56.992  97.518  1.00 57.03  ?  804 ILE A CG1 1 
ATOM   4973 C CG2 . ILE A 1 823 ? -3.301  58.096  95.255  1.00 49.62  ?  804 ILE A CG2 1 
ATOM   4974 C CD1 . ILE A 1 823 ? -4.845  57.152  97.802  1.00 52.88  ?  804 ILE A CD1 1 
ATOM   4975 N N   . ARG A 1 824 ? 0.400   56.401  96.992  1.00 65.15  ?  805 ARG A N   1 
ATOM   4976 C CA  . ARG A 1 824 ? 1.288   55.311  96.551  1.00 67.10  ?  805 ARG A CA  1 
ATOM   4977 C C   . ARG A 1 824 ? 0.547   54.111  95.947  1.00 67.19  ?  805 ARG A C   1 
ATOM   4978 O O   . ARG A 1 824 ? 0.933   53.596  94.892  1.00 65.04  ?  805 ARG A O   1 
ATOM   4979 C CB  . ARG A 1 824 ? 2.130   54.833  97.741  1.00 65.85  ?  805 ARG A CB  1 
ATOM   4980 C CG  . ARG A 1 824 ? 3.274   53.950  97.405  1.00 59.71  ?  805 ARG A CG  1 
ATOM   4981 C CD  . ARG A 1 824 ? 4.056   53.540  98.643  1.00 58.06  ?  805 ARG A CD  1 
ATOM   4982 N NE  . ARG A 1 824 ? 5.126   52.634  98.243  1.00 66.72  ?  805 ARG A NE  1 
ATOM   4983 C CZ  . ARG A 1 824 ? 6.365   52.630  98.725  1.00 66.28  ?  805 ARG A CZ  1 
ATOM   4984 N NH1 . ARG A 1 824 ? 6.731   53.468  99.686  1.00 64.53  ?  805 ARG A NH1 1 
ATOM   4985 N NH2 . ARG A 1 824 ? 7.246   51.767  98.231  1.00 66.90  ?  805 ARG A NH2 1 
ATOM   4986 N N   . ASN A 1 825 ? -0.485  53.612  96.628  1.00 67.75  ?  806 ASN A N   1 
ATOM   4987 C CA  . ASN A 1 825 ? -1.108  52.369  96.174  1.00 67.62  ?  806 ASN A CA  1 
ATOM   4988 C C   . ASN A 1 825 ? -2.152  52.559  95.074  1.00 71.04  ?  806 ASN A C   1 
ATOM   4989 O O   . ASN A 1 825 ? -2.637  51.550  94.534  1.00 72.58  ?  806 ASN A O   1 
ATOM   4990 C CB  . ASN A 1 825 ? -1.735  51.627  97.353  1.00 60.21  ?  806 ASN A CB  1 
ATOM   4991 C CG  . ASN A 1 825 ? -0.707  51.205  98.353  1.00 65.39  ?  806 ASN A CG  1 
ATOM   4992 O OD1 . ASN A 1 825 ? 0.494   51.185  98.056  1.00 64.51  ?  806 ASN A OD1 1 
ATOM   4993 N ND2 . ASN A 1 825 ? -1.155  50.869  99.558  1.00 69.77  ?  806 ASN A ND2 1 
ATOM   4994 N N   . TYR A 1 826 ? -2.529  53.808  94.736  1.00 59.23  ?  807 TYR A N   1 
ATOM   4995 C CA  . TYR A 1 826 ? -3.494  53.975  93.659  1.00 60.84  ?  807 TYR A CA  1 
ATOM   4996 C C   . TYR A 1 826 ? -3.161  55.197  92.811  1.00 64.21  ?  807 TYR A C   1 
ATOM   4997 O O   . TYR A 1 826 ? -4.047  56.025  92.538  1.00 60.21  ?  807 TYR A O   1 
ATOM   4998 C CB  . TYR A 1 826 ? -4.925  54.083  94.206  1.00 58.15  ?  807 TYR A CB  1 
ATOM   4999 C CG  . TYR A 1 826 ? -5.266  53.033  95.225  1.00 64.12  ?  807 TYR A CG  1 
ATOM   5000 C CD1 . TYR A 1 826 ? -4.949  53.210  96.569  1.00 68.66  ?  807 TYR A CD1 1 
ATOM   5001 C CD2 . TYR A 1 826 ? -5.902  51.850  94.854  1.00 68.17  ?  807 TYR A CD2 1 
ATOM   5002 C CE1 . TYR A 1 826 ? -5.246  52.217  97.514  1.00 74.42  ?  807 TYR A CE1 1 
ATOM   5003 C CE2 . TYR A 1 826 ? -6.216  50.867  95.787  1.00 65.88  ?  807 TYR A CE2 1 
ATOM   5004 C CZ  . TYR A 1 826 ? -5.883  51.046  97.109  1.00 71.32  ?  807 TYR A CZ  1 
ATOM   5005 O OH  . TYR A 1 826 ? -6.183  50.081  98.046  1.00 70.36  ?  807 TYR A OH  1 
ATOM   5006 N N   . PRO A 1 827 ? -1.921  55.331  92.337  1.00 64.17  ?  808 PRO A N   1 
ATOM   5007 C CA  . PRO A 1 827 ? -1.577  56.515  91.552  1.00 59.98  ?  808 PRO A CA  1 
ATOM   5008 C C   . PRO A 1 827 ? -2.390  56.575  90.277  1.00 59.55  ?  808 PRO A C   1 
ATOM   5009 O O   . PRO A 1 827 ? -3.017  55.603  89.856  1.00 67.53  ?  808 PRO A O   1 
ATOM   5010 C CB  . PRO A 1 827 ? -0.087  56.329  91.254  1.00 59.10  ?  808 PRO A CB  1 
ATOM   5011 C CG  . PRO A 1 827 ? 0.132   54.891  91.368  1.00 64.21  ?  808 PRO A CG  1 
ATOM   5012 C CD  . PRO A 1 827 ? -0.804  54.376  92.392  1.00 60.24  ?  808 PRO A CD  1 
ATOM   5013 N N   . ALA A 1 828 ? -2.409  57.761  89.694  1.00 61.46  ?  809 ALA A N   1 
ATOM   5014 C CA  . ALA A 1 828 ? -2.784  57.969  88.307  1.00 61.18  ?  809 ALA A CA  1 
ATOM   5015 C C   . ALA A 1 828 ? -4.206  57.549  88.005  1.00 65.58  ?  809 ALA A C   1 
ATOM   5016 O O   . ALA A 1 828 ? -4.523  57.210  86.870  1.00 72.81  ?  809 ALA A O   1 
ATOM   5017 C CB  . ALA A 1 828 ? -1.812  57.240  87.386  1.00 63.70  ?  809 ALA A CB  1 
ATOM   5018 N N   . THR A 1 829 ? -5.097  57.549  88.980  1.00 61.33  ?  810 THR A N   1 
ATOM   5019 C CA  . THR A 1 829 ? -6.483  57.210  88.700  1.00 68.40  ?  810 THR A CA  1 
ATOM   5020 C C   . THR A 1 829 ? -7.387  58.241  89.343  1.00 68.23  ?  810 THR A C   1 
ATOM   5021 O O   . THR A 1 829 ? -6.929  59.120  90.068  1.00 67.00  ?  810 THR A O   1 
ATOM   5022 C CB  . THR A 1 829 ? -6.844  55.829  89.235  1.00 68.11  ?  810 THR A CB  1 
ATOM   5023 O OG1 . THR A 1 829 ? -6.672  55.849  90.659  1.00 66.85  ?  810 THR A OG1 1 
ATOM   5024 C CG2 . THR A 1 829 ? -5.955  54.770  88.605  1.00 67.66  ?  810 THR A CG2 1 
ATOM   5025 N N   . VAL A 1 830 ? -8.688  58.117  89.094  1.00 67.80  ?  811 VAL A N   1 
ATOM   5026 C CA  . VAL A 1 830 ? -9.631  58.984  89.778  1.00 58.91  ?  811 VAL A CA  1 
ATOM   5027 C C   . VAL A 1 830 ? -9.855  58.504  91.195  1.00 63.87  ?  811 VAL A C   1 
ATOM   5028 O O   . VAL A 1 830 ? -9.748  59.277  92.151  1.00 65.62  ?  811 VAL A O   1 
ATOM   5029 C CB  . VAL A 1 830 ? -10.953 59.074  89.019  1.00 63.10  ?  811 VAL A CB  1 
ATOM   5030 C CG1 . VAL A 1 830 ? -12.029 59.526  89.983  1.00 59.95  ?  811 VAL A CG1 1 
ATOM   5031 C CG2 . VAL A 1 830 ? -10.820 60.028  87.837  1.00 62.30  ?  811 VAL A CG2 1 
ATOM   5032 N N   . HIS A 1 831 ? -10.152 57.217  91.367  1.00 66.71  ?  812 HIS A N   1 
ATOM   5033 C CA  . HIS A 1 831 ? -10.333 56.724  92.724  1.00 65.21  ?  812 HIS A CA  1 
ATOM   5034 C C   . HIS A 1 831 ? -9.118  57.062  93.582  1.00 64.93  ?  812 HIS A C   1 
ATOM   5035 O O   . HIS A 1 831 ? -9.257  57.318  94.782  1.00 68.35  ?  812 HIS A O   1 
ATOM   5036 C CB  . HIS A 1 831 ? -10.647 55.216  92.725  1.00 64.05  ?  812 HIS A CB  1 
ATOM   5037 C CG  . HIS A 1 831 ? -9.682  54.369  91.940  1.00 67.47  ?  812 HIS A CG  1 
ATOM   5038 N ND1 . HIS A 1 831 ? -8.583  53.752  92.514  1.00 61.20  ?  812 HIS A ND1 1 
ATOM   5039 C CD2 . HIS A 1 831 ? -9.672  54.015  90.629  1.00 63.43  ?  812 HIS A CD2 1 
ATOM   5040 C CE1 . HIS A 1 831 ? -7.916  53.092  91.584  1.00 62.91  ?  812 HIS A CE1 1 
ATOM   5041 N NE2 . HIS A 1 831 ? -8.560  53.231  90.433  1.00 68.81  ?  812 HIS A NE2 1 
ATOM   5042 N N   . GLY A 1 832 ? -7.932  57.136  92.977  1.00 62.14  ?  813 GLY A N   1 
ATOM   5043 C CA  . GLY A 1 832 ? -6.743  57.431  93.756  1.00 62.01  ?  813 GLY A CA  1 
ATOM   5044 C C   . GLY A 1 832 ? -6.680  58.885  94.182  1.00 61.99  ?  813 GLY A C   1 
ATOM   5045 O O   . GLY A 1 832 ? -6.322  59.196  95.320  1.00 59.21  ?  813 GLY A O   1 
ATOM   5046 N N   . ALA A 1 833 ? -6.995  59.797  93.269  1.00 58.36  ?  814 ALA A N   1 
ATOM   5047 C CA  . ALA A 1 833 ? -7.125  61.190  93.656  1.00 61.07  ?  814 ALA A CA  1 
ATOM   5048 C C   . ALA A 1 833 ? -8.114  61.306  94.806  1.00 61.42  ?  814 ALA A C   1 
ATOM   5049 O O   . ALA A 1 833 ? -7.787  61.786  95.895  1.00 62.51  ?  814 ALA A O   1 
ATOM   5050 C CB  . ALA A 1 833 ? -7.573  62.027  92.451  1.00 58.02  ?  814 ALA A CB  1 
ATOM   5051 N N   . LEU A 1 834 ? -9.322  60.809  94.579  1.00 62.47  ?  815 LEU A N   1 
ATOM   5052 C CA  . LEU A 1 834 ? -10.384 60.919  95.561  1.00 59.67  ?  815 LEU A CA  1 
ATOM   5053 C C   . LEU A 1 834 ? -9.943  60.412  96.923  1.00 60.32  ?  815 LEU A C   1 
ATOM   5054 O O   . LEU A 1 834 ? -10.226 61.035  97.945  1.00 67.25  ?  815 LEU A O   1 
ATOM   5055 C CB  . LEU A 1 834 ? -11.604 60.155  95.066  1.00 65.91  ?  815 LEU A CB  1 
ATOM   5056 C CG  . LEU A 1 834 ? -12.852 60.183  95.924  1.00 64.67  ?  815 LEU A CG  1 
ATOM   5057 C CD1 . LEU A 1 834 ? -14.067 60.214  95.018  1.00 70.47  ?  815 LEU A CD1 1 
ATOM   5058 C CD2 . LEU A 1 834 ? -12.870 58.963  96.786  1.00 65.87  ?  815 LEU A CD2 1 
ATOM   5059 N N   . LEU A 1 835 ? -9.236  59.291  96.973  1.00 64.52  ?  816 LEU A N   1 
ATOM   5060 C CA  . LEU A 1 835 ? -8.786  58.827  98.279  1.00 63.18  ?  816 LEU A CA  1 
ATOM   5061 C C   . LEU A 1 835 ? -7.749  59.777  98.858  1.00 57.12  ?  816 LEU A C   1 
ATOM   5062 O O   . LEU A 1 835 ? -7.687  59.959  100.076 1.00 62.20  ?  816 LEU A O   1 
ATOM   5063 C CB  . LEU A 1 835 ? -8.223  57.401  98.220  1.00 61.82  ?  816 LEU A CB  1 
ATOM   5064 C CG  . LEU A 1 835 ? -9.078  56.186  97.847  1.00 67.48  ?  816 LEU A CG  1 
ATOM   5065 C CD1 . LEU A 1 835 ? -8.237  54.932  97.958  1.00 70.23  ?  816 LEU A CD1 1 
ATOM   5066 C CD2 . LEU A 1 835 ? -10.341 56.025  98.657  1.00 68.83  ?  816 LEU A CD2 1 
ATOM   5067 N N   . SER A 1 836 ? -6.918  60.389  98.007  1.00 57.80  ?  817 SER A N   1 
ATOM   5068 C CA  . SER A 1 836 ? -5.884  61.281  98.526  1.00 60.33  ?  817 SER A CA  1 
ATOM   5069 C C   . SER A 1 836 ? -6.505  62.525  99.151  1.00 62.95  ?  817 SER A C   1 
ATOM   5070 O O   . SER A 1 836 ? -6.031  63.001  100.193 1.00 61.96  ?  817 SER A O   1 
ATOM   5071 C CB  . SER A 1 836 ? -4.878  61.647  97.427  1.00 56.96  ?  817 SER A CB  1 
ATOM   5072 O OG  . SER A 1 836 ? -5.357  62.677  96.585  1.00 57.45  ?  817 SER A OG  1 
ATOM   5073 N N   . GLY A 1 837 ? -7.604  63.014  98.574  1.00 59.82  ?  818 GLY A N   1 
ATOM   5074 C CA  . GLY A 1 837 ? -8.341  64.094  99.206  1.00 60.74  ?  818 GLY A CA  1 
ATOM   5075 C C   . GLY A 1 837 ? -8.975  63.674  100.517 1.00 65.03  ?  818 GLY A C   1 
ATOM   5076 O O   . GLY A 1 837 ? -8.919  64.406  101.509 1.00 67.71  ?  818 GLY A O   1 
ATOM   5077 N N   . LEU A 1 838 ? -9.595  62.498  100.541 1.00 65.64  ?  819 LEU A N   1 
ATOM   5078 C CA  . LEU A 1 838 ? -10.156 62.008  101.787 1.00 57.84  ?  819 LEU A CA  1 
ATOM   5079 C C   . LEU A 1 838 ? -9.095  61.938  102.866 1.00 61.24  ?  819 LEU A C   1 
ATOM   5080 O O   . LEU A 1 838 ? -9.374  62.273  104.025 1.00 67.67  ?  819 LEU A O   1 
ATOM   5081 C CB  . LEU A 1 838 ? -10.802 60.642  101.595 1.00 58.52  ?  819 LEU A CB  1 
ATOM   5082 C CG  . LEU A 1 838 ? -12.061 60.560  100.757 1.00 62.76  ?  819 LEU A CG  1 
ATOM   5083 C CD1 . LEU A 1 838 ? -12.747 59.205  100.955 1.00 69.26  ?  819 LEU A CD1 1 
ATOM   5084 C CD2 . LEU A 1 838 ? -12.977 61.681  101.105 1.00 61.98  ?  819 LEU A CD2 1 
ATOM   5085 N N   . ARG A 1 839 ? -7.869  61.521  102.522 1.00 54.67  ?  820 ARG A N   1 
ATOM   5086 C CA  . ARG A 1 839 ? -6.950  61.374  103.641 1.00 57.55  ?  820 ARG A CA  1 
ATOM   5087 C C   . ARG A 1 839 ? -6.424  62.734  104.102 1.00 61.96  ?  820 ARG A C   1 
ATOM   5088 O O   . ARG A 1 839 ? -6.283  62.949  105.305 1.00 66.98  ?  820 ARG A O   1 
ATOM   5089 C CB  . ARG A 1 839 ? -5.772  60.431  103.349 1.00 51.84  ?  820 ARG A CB  1 
ATOM   5090 C CG  . ARG A 1 839 ? -4.659  61.089  102.696 1.00 58.04  ?  820 ARG A CG  1 
ATOM   5091 C CD  . ARG A 1 839 ? -3.375  60.380  102.638 1.00 63.54  ?  820 ARG A CD  1 
ATOM   5092 N NE  . ARG A 1 839 ? -2.497  61.331  101.953 1.00 72.43  ?  820 ARG A NE  1 
ATOM   5093 C CZ  . ARG A 1 839 ? -2.301  61.379  100.627 1.00 71.68  ?  820 ARG A CZ  1 
ATOM   5094 N NH1 . ARG A 1 839 ? -2.863  60.503  99.810  1.00 66.81  ?  820 ARG A NH1 1 
ATOM   5095 N NH2 . ARG A 1 839 ? -1.516  62.306  100.105 1.00 75.53  ?  820 ARG A NH2 1 
ATOM   5096 N N   . GLU A 1 840 ? -6.128  63.681  103.201 1.00 58.57  ?  821 GLU A N   1 
ATOM   5097 C CA  . GLU A 1 840 ? -5.641  64.949  103.729 1.00 58.91  ?  821 GLU A CA  1 
ATOM   5098 C C   . GLU A 1 840 ? -6.699  65.611  104.588 1.00 65.54  ?  821 GLU A C   1 
ATOM   5099 O O   . GLU A 1 840 ? -6.363  66.241  105.593 1.00 69.25  ?  821 GLU A O   1 
ATOM   5100 C CB  . GLU A 1 840 ? -5.188  65.919  102.645 1.00 48.39  ?  821 GLU A CB  1 
ATOM   5101 C CG  . GLU A 1 840 ? -3.955  65.486  101.932 1.00 61.69  ?  821 GLU A CG  1 
ATOM   5102 C CD  . GLU A 1 840 ? -2.734  65.312  102.834 1.00 68.34  ?  821 GLU A CD  1 
ATOM   5103 O OE1 . GLU A 1 840 ? -1.958  66.283  103.037 1.00 64.62  ?  821 GLU A OE1 1 
ATOM   5104 O OE2 . GLU A 1 840 ? -2.503  64.158  103.280 1.00 70.67  ?  821 GLU A OE2 1 
ATOM   5105 N N   . ALA A 1 841 ? -7.978  65.465  104.243 1.00 60.06  ?  822 ALA A N   1 
ATOM   5106 C CA  . ALA A 1 841 ? -8.992  66.059  105.099 1.00 60.18  ?  822 ALA A CA  1 
ATOM   5107 C C   . ALA A 1 841 ? -8.917  65.476  106.508 1.00 65.66  ?  822 ALA A C   1 
ATOM   5108 O O   . ALA A 1 841 ? -8.949  66.212  107.496 1.00 67.85  ?  822 ALA A O   1 
ATOM   5109 C CB  . ALA A 1 841 ? -10.379 65.874  104.504 1.00 59.37  ?  822 ALA A CB  1 
ATOM   5110 N N   . GLY A 1 842 ? -8.790  64.163  106.626 1.00 64.69  ?  823 GLY A N   1 
ATOM   5111 C CA  . GLY A 1 842 ? -8.559  63.591  107.937 1.00 67.31  ?  823 GLY A CA  1 
ATOM   5112 C C   . GLY A 1 842 ? -7.309  64.150  108.591 1.00 69.21  ?  823 GLY A C   1 
ATOM   5113 O O   . GLY A 1 842 ? -7.287  64.411  109.796 1.00 71.77  ?  823 GLY A O   1 
ATOM   5114 N N   . ARG A 1 843 ? -6.258  64.361  107.805 1.00 64.88  ?  824 ARG A N   1 
ATOM   5115 C CA  . ARG A 1 843 ? -4.998  64.785  108.397 1.00 68.23  ?  824 ARG A CA  1 
ATOM   5116 C C   . ARG A 1 843 ? -5.091  66.217  108.890 1.00 68.80  ?  824 ARG A C   1 
ATOM   5117 O O   . ARG A 1 843 ? -4.602  66.544  109.976 1.00 70.84  ?  824 ARG A O   1 
ATOM   5118 C CB  . ARG A 1 843 ? -3.855  64.660  107.392 1.00 63.43  ?  824 ARG A CB  1 
ATOM   5119 C CG  . ARG A 1 843 ? -2.545  64.686  108.094 1.00 66.18  ?  824 ARG A CG  1 
ATOM   5120 C CD  . ARG A 1 843 ? -1.388  65.117  107.239 1.00 71.81  ?  824 ARG A CD  1 
ATOM   5121 N NE  . ARG A 1 843 ? -1.200  64.319  106.035 1.00 75.98  ?  824 ARG A NE  1 
ATOM   5122 C CZ  . ARG A 1 843 ? -0.209  63.441  105.885 1.00 76.19  ?  824 ARG A CZ  1 
ATOM   5123 N NH1 . ARG A 1 843 ? 0.646   63.189  106.888 1.00 73.03  ?  824 ARG A NH1 1 
ATOM   5124 N NH2 . ARG A 1 843 ? -0.096  62.785  104.743 1.00 77.42  ?  824 ARG A NH2 1 
ATOM   5125 N N   . ILE A 1 844 ? -5.708  67.075  108.087 1.00 67.05  ?  825 ILE A N   1 
ATOM   5126 C CA  . ILE A 1 844 ? -5.863  68.480  108.428 1.00 71.96  ?  825 ILE A CA  1 
ATOM   5127 C C   . ILE A 1 844 ? -6.767  68.633  109.644 1.00 71.72  ?  825 ILE A C   1 
ATOM   5128 O O   . ILE A 1 844 ? -6.449  69.382  110.574 1.00 71.59  ?  825 ILE A O   1 
ATOM   5129 C CB  . ILE A 1 844 ? -6.390  69.240  107.191 1.00 69.49  ?  825 ILE A CB  1 
ATOM   5130 C CG1 . ILE A 1 844 ? -5.224  69.585  106.251 1.00 61.38  ?  825 ILE A CG1 1 
ATOM   5131 C CG2 . ILE A 1 844 ? -7.252  70.438  107.588 1.00 64.00  ?  825 ILE A CG2 1 
ATOM   5132 C CD1 . ILE A 1 844 ? -5.651  69.785  104.867 1.00 62.24  ?  825 ILE A CD1 1 
ATOM   5133 N N   . ALA A 1 845 ? -7.881  67.896  109.678 1.00 65.43  ?  826 ALA A N   1 
ATOM   5134 C CA  . ALA A 1 845 ? -8.780  67.973  110.820 1.00 67.97  ?  826 ALA A CA  1 
ATOM   5135 C C   . ALA A 1 845 ? -8.128  67.427  112.086 1.00 75.00  ?  826 ALA A C   1 
ATOM   5136 O O   . ALA A 1 845 ? -8.313  67.981  113.174 1.00 75.08  ?  826 ALA A O   1 
ATOM   5137 C CB  . ALA A 1 845 ? -10.071 67.226  110.519 1.00 71.08  ?  826 ALA A CB  1 
ATOM   5138 N N   . ASP A 1 846 ? -7.364  66.338  111.973 1.00 79.10  ?  827 ASP A N   1 
ATOM   5139 C CA  . ASP A 1 846 ? -6.603  65.862  113.127 1.00 79.12  ?  827 ASP A CA  1 
ATOM   5140 C C   . ASP A 1 846 ? -5.720  66.972  113.687 1.00 76.67  ?  827 ASP A C   1 
ATOM   5141 O O   . ASP A 1 846 ? -5.457  67.019  114.892 1.00 80.90  ?  827 ASP A O   1 
ATOM   5142 C CB  . ASP A 1 846 ? -5.749  64.642  112.735 1.00 75.18  ?  827 ASP A CB  1 
ATOM   5143 C CG  . ASP A 1 846 ? -6.556  63.329  112.678 1.00 83.92  ?  827 ASP A CG  1 
ATOM   5144 O OD1 . ASP A 1 846 ? -7.773  63.322  113.018 1.00 80.06  ?  827 ASP A OD1 1 
ATOM   5145 O OD2 . ASP A 1 846 ? -5.964  62.300  112.256 1.00 87.56  ?  827 ASP A OD2 1 
ATOM   5146 N N   . GLN A 1 847 ? -5.279  67.883  112.827 1.00 75.04  ?  828 GLN A N   1 
ATOM   5147 C CA  . GLN A 1 847 ? -4.323  68.915  113.182 1.00 75.57  ?  828 GLN A CA  1 
ATOM   5148 C C   . GLN A 1 847 ? -4.990  70.158  113.739 1.00 79.55  ?  828 GLN A C   1 
ATOM   5149 O O   . GLN A 1 847 ? -4.430  70.804  114.624 1.00 81.93  ?  828 GLN A O   1 
ATOM   5150 C CB  . GLN A 1 847 ? -3.500  69.304  111.948 1.00 77.48  ?  828 GLN A CB  1 
ATOM   5151 C CG  . GLN A 1 847 ? -2.283  70.194  112.205 1.00 77.74  ?  828 GLN A CG  1 
ATOM   5152 C CD  . GLN A 1 847 ? -1.328  69.577  113.203 1.00 92.34  ?  828 GLN A CD  1 
ATOM   5153 O OE1 . GLN A 1 847 ? -0.641  68.574  112.914 1.00 96.29  ?  828 GLN A OE1 1 
ATOM   5154 N NE2 . GLN A 1 847 ? -1.277  70.166  114.398 1.00 89.11  ?  828 GLN A NE2 1 
ATOM   5155 N N   . PHE A 1 848 ? -6.166  70.517  113.240 1.00 77.14  ?  829 PHE A N   1 
ATOM   5156 C CA  . PHE A 1 848 ? -6.755  71.800  113.553 1.00 73.86  ?  829 PHE A CA  1 
ATOM   5157 C C   . PHE A 1 848 ? -8.048  71.690  114.332 1.00 76.92  ?  829 PHE A C   1 
ATOM   5158 O O   . PHE A 1 848 ? -8.524  72.699  114.852 1.00 79.10  ?  829 PHE A O   1 
ATOM   5159 C CB  . PHE A 1 848 ? -6.975  72.600  112.262 1.00 71.75  ?  829 PHE A CB  1 
ATOM   5160 C CG  . PHE A 1 848 ? -5.695  73.079  111.653 1.00 72.92  ?  829 PHE A CG  1 
ATOM   5161 C CD1 . PHE A 1 848 ? -5.188  74.332  111.958 1.00 76.93  ?  829 PHE A CD1 1 
ATOM   5162 C CD2 . PHE A 1 848 ? -4.956  72.260  110.836 1.00 72.34  ?  829 PHE A CD2 1 
ATOM   5163 C CE1 . PHE A 1 848 ? -3.975  74.773  111.428 1.00 70.12  ?  829 PHE A CE1 1 
ATOM   5164 C CE2 . PHE A 1 848 ? -3.752  72.692  110.299 1.00 70.69  ?  829 PHE A CE2 1 
ATOM   5165 C CZ  . PHE A 1 848 ? -3.265  73.952  110.593 1.00 70.26  ?  829 PHE A CZ  1 
ATOM   5166 N N   . LEU A 1 849 ? -8.615  70.505  114.445 1.00 78.29  ?  830 LEU A N   1 
ATOM   5167 C CA  . LEU A 1 849 ? -9.773  70.269  115.286 1.00 76.91  ?  830 LEU A CA  1 
ATOM   5168 C C   . LEU A 1 849 ? -9.458  69.310  116.415 1.00 76.96  ?  830 LEU A C   1 
ATOM   5169 O O   . LEU A 1 849 ? -10.312 69.088  117.275 1.00 85.75  ?  830 LEU A O   1 
ATOM   5170 C CB  . LEU A 1 849 ? -10.927 69.704  114.455 1.00 73.93  ?  830 LEU A CB  1 
ATOM   5171 C CG  . LEU A 1 849 ? -11.257 70.420  113.159 1.00 71.58  ?  830 LEU A CG  1 
ATOM   5172 C CD1 . LEU A 1 849 ? -12.577 69.892  112.689 1.00 71.33  ?  830 LEU A CD1 1 
ATOM   5173 C CD2 . LEU A 1 849 ? -11.329 71.947  113.378 1.00 76.41  ?  830 LEU A CD2 1 
ATOM   5174 N N   . GLY A 1 850 ? -8.262  68.732  116.428 1.00 74.92  ?  831 GLY A N   1 
ATOM   5175 C CA  . GLY A 1 850 ? -7.897  67.737  117.413 1.00 83.88  ?  831 GLY A CA  1 
ATOM   5176 C C   . GLY A 1 850 ? -8.562  66.400  117.159 1.00 89.23  ?  831 GLY A C   1 
ATOM   5177 O O   . GLY A 1 850 ? -9.677  66.339  116.621 1.00 85.84  ?  831 GLY A O   1 
ATOM   5178 N N   . ALA A 1 851 ? -7.884  65.323  117.544 1.00 90.14  ?  832 ALA A N   1 
ATOM   5179 C CA  . ALA A 1 851 ? -8.366  63.957  117.339 1.00 101.61 ?  832 ALA A CA  1 
ATOM   5180 C C   . ALA A 1 851 ? -8.729  63.375  118.707 1.00 106.82 ?  832 ALA A C   1 
ATOM   5181 O O   . ALA A 1 851 ? -7.900  62.749  119.375 1.00 107.74 ?  832 ALA A O   1 
ATOM   5182 C CB  . ALA A 1 851 ? -7.314  63.106  116.614 1.00 94.84  ?  832 ALA A CB  1 
ATOM   5183 N N   . MET A 1 852 ? -9.990  63.560  119.107 1.00 103.57 ?  833 MET A N   1 
ATOM   5184 C CA  . MET A 1 852 ? -10.403 63.186  120.456 1.00 108.36 ?  833 MET A CA  1 
ATOM   5185 C C   . MET A 1 852 ? -10.421 61.668  120.664 1.00 107.60 ?  833 MET A C   1 
ATOM   5186 O O   . MET A 1 852 ? -10.384 61.215  121.816 1.00 108.56 ?  833 MET A O   1 
ATOM   5187 C CB  . MET A 1 852 ? -11.781 63.794  120.750 1.00 113.54 ?  833 MET A CB  1 
ATOM   5188 C CG  . MET A 1 852 ? -11.940 65.320  120.399 1.00 118.29 ?  833 MET A CG  1 
ATOM   5189 S SD  . MET A 1 852 ? -10.615 66.524  120.787 1.00 130.26 ?  833 MET A SD  1 
ATOM   5190 C CE  . MET A 1 852 ? -11.472 68.114  120.739 1.00 99.93  ?  833 MET A CE  1 
ATOM   5191 N N   . TYR A 1 853 ? -10.428 60.879  119.572 1.00 105.94 ?  834 TYR A N   1 
ATOM   5192 C CA  . TYR A 1 853 ? -10.630 59.426  119.545 1.00 102.18 ?  834 TYR A CA  1 
ATOM   5193 C C   . TYR A 1 853 ? -9.353  58.611  119.804 1.00 101.01 ?  834 TYR A C   1 
ATOM   5194 O O   . TYR A 1 853 ? -9.372  57.388  119.622 1.00 96.94  ?  834 TYR A O   1 
ATOM   5195 C CB  . TYR A 1 853 ? -11.230 59.008  118.186 1.00 101.59 ?  834 TYR A CB  1 
ATOM   5196 C CG  . TYR A 1 853 ? -10.392 59.466  116.999 1.00 104.44 ?  834 TYR A CG  1 
ATOM   5197 C CD1 . TYR A 1 853 ? -10.730 60.625  116.292 1.00 100.43 ?  834 TYR A CD1 1 
ATOM   5198 C CD2 . TYR A 1 853 ? -9.255  58.753  116.596 1.00 101.05 ?  834 TYR A CD2 1 
ATOM   5199 C CE1 . TYR A 1 853 ? -9.954  61.070  115.226 1.00 95.67  ?  834 TYR A CE1 1 
ATOM   5200 C CE2 . TYR A 1 853 ? -8.471  59.192  115.528 1.00 99.30  ?  834 TYR A CE2 1 
ATOM   5201 C CZ  . TYR A 1 853 ? -8.827  60.350  114.842 1.00 97.70  ?  834 TYR A CZ  1 
ATOM   5202 O OH  . TYR A 1 853 ? -8.054  60.788  113.779 1.00 91.29  ?  834 TYR A OH  1 
ATOM   5203 N N   . THR A 1 854 ? -8.248  59.231  120.209 1.00 104.98 ?  835 THR A N   1 
ATOM   5204 C CA  . THR A 1 854 ? -7.000  58.502  120.399 1.00 103.83 ?  835 THR A CA  1 
ATOM   5205 C C   . THR A 1 854 ? -6.686  58.222  121.875 1.00 108.41 ?  835 THR A C   1 
ATOM   5206 O O   . THR A 1 854 ? -5.551  57.841  122.189 1.00 110.09 ?  835 THR A O   1 
ATOM   5207 C CB  . THR A 1 854 ? -5.847  59.264  119.722 1.00 107.13 ?  835 THR A CB  1 
ATOM   5208 O OG1 . THR A 1 854 ? -5.982  60.673  119.966 1.00 105.82 ?  835 THR A OG1 1 
ATOM   5209 C CG2 . THR A 1 854 ? -5.856  59.028  118.209 1.00 97.05  ?  835 THR A CG2 1 
ATOM   5210 N N   . LEU A 1 855 ? -7.669  58.377  122.776 1.00 107.54 ?  836 LEU A N   1 
ATOM   5211 C CA  . LEU A 1 855 ? -7.510  58.108  124.217 1.00 99.97  ?  836 LEU A CA  1 
ATOM   5212 C C   . LEU A 1 855 ? -7.975  56.691  124.612 1.00 98.01  ?  836 LEU A C   1 
ATOM   5213 O O   . LEU A 1 855 ? -7.890  56.266  125.778 1.00 91.74  ?  836 LEU A O   1 
ATOM   5214 C CB  . LEU A 1 855 ? -8.289  59.146  125.035 1.00 110.22 ?  836 LEU A CB  1 
ATOM   5215 C CG  . LEU A 1 855 ? -7.645  60.498  125.377 1.00 108.56 ?  836 LEU A CG  1 
ATOM   5216 C CD1 . LEU A 1 855 ? -7.650  61.419  124.144 1.00 96.30  ?  836 LEU A CD1 1 
ATOM   5217 C CD2 . LEU A 1 855 ? -8.297  61.148  126.639 1.00 90.76  ?  836 LEU A CD2 1 
ATOM   5218 N N   . ARG B 2 12  ? 11.334  31.606  90.168  1.00 126.50 ?  308 ARG B N   1 
ATOM   5219 C CA  . ARG B 2 12  ? 12.538  30.784  90.288  1.00 132.20 ?  308 ARG B CA  1 
ATOM   5220 C C   . ARG B 2 12  ? 13.076  30.387  88.905  1.00 130.44 ?  308 ARG B C   1 
ATOM   5221 O O   . ARG B 2 12  ? 14.265  30.093  88.758  1.00 130.53 ?  308 ARG B O   1 
ATOM   5222 C CB  . ARG B 2 12  ? 12.266  29.523  91.134  1.00 134.58 ?  308 ARG B CB  1 
ATOM   5223 C CG  . ARG B 2 12  ? 12.479  29.691  92.644  1.00 137.33 ?  308 ARG B CG  1 
ATOM   5224 C CD  . ARG B 2 12  ? 13.962  29.658  93.017  1.00 145.15 ?  308 ARG B CD  1 
ATOM   5225 N NE  . ARG B 2 12  ? 14.213  30.107  94.391  1.00 151.05 ?  308 ARG B NE  1 
ATOM   5226 C CZ  . ARG B 2 12  ? 14.711  31.301  94.721  1.00 151.80 ?  308 ARG B CZ  1 
ATOM   5227 N NH1 . ARG B 2 12  ? 15.015  32.193  93.782  1.00 144.73 ?  308 ARG B NH1 1 
ATOM   5228 N NH2 . ARG B 2 12  ? 14.903  31.610  95.998  1.00 154.42 ?  308 ARG B NH2 1 
ATOM   5229 N N   . LYS B 2 13  ? 12.209  30.384  87.891  1.00 125.57 ?  309 LYS B N   1 
ATOM   5230 C CA  . LYS B 2 13  ? 12.598  29.943  86.555  1.00 119.58 ?  309 LYS B CA  1 
ATOM   5231 C C   . LYS B 2 13  ? 11.863  30.781  85.514  1.00 116.62 ?  309 LYS B C   1 
ATOM   5232 O O   . LYS B 2 13  ? 10.730  31.213  85.762  1.00 115.90 ?  309 LYS B O   1 
ATOM   5233 C CB  . LYS B 2 13  ? 12.297  28.445  86.353  1.00 121.59 ?  309 LYS B CB  1 
ATOM   5234 C CG  . LYS B 2 13  ? 13.332  27.481  86.990  1.00 128.97 ?  309 LYS B CG  1 
ATOM   5235 C CD  . LYS B 2 13  ? 13.284  26.048  86.391  1.00 126.33 ?  309 LYS B CD  1 
ATOM   5236 C CE  . LYS B 2 13  ? 14.442  25.150  86.900  1.00 122.45 ?  309 LYS B CE  1 
ATOM   5237 N NZ  . LYS B 2 13  ? 14.570  23.824  86.202  1.00 102.38 ?  309 LYS B NZ  1 
ATOM   5238 N N   . PRO B 2 14  ? 12.473  31.023  84.348  1.00 111.74 ?  310 PRO B N   1 
ATOM   5239 C CA  . PRO B 2 14  ? 11.834  31.863  83.309  1.00 105.90 ?  310 PRO B CA  1 
ATOM   5240 C C   . PRO B 2 14  ? 10.560  31.228  82.789  1.00 107.61 ?  310 PRO B C   1 
ATOM   5241 O O   . PRO B 2 14  ? 10.326  30.031  83.004  1.00 114.93 ?  310 PRO B O   1 
ATOM   5242 C CB  . PRO B 2 14  ? 12.893  31.925  82.195  1.00 100.19 ?  310 PRO B CB  1 
ATOM   5243 C CG  . PRO B 2 14  ? 14.158  31.489  82.816  1.00 102.41 ?  310 PRO B CG  1 
ATOM   5244 C CD  . PRO B 2 14  ? 13.799  30.546  83.922  1.00 108.49 ?  310 PRO B CD  1 
ATOM   5245 N N   . PRO B 2 15  ? 9.714   31.989  82.095  1.00 107.51 ?  311 PRO B N   1 
ATOM   5246 C CA  . PRO B 2 15  ? 8.642   31.360  81.317  1.00 109.37 ?  311 PRO B CA  1 
ATOM   5247 C C   . PRO B 2 15  ? 9.252   30.345  80.375  1.00 112.61 ?  311 PRO B C   1 
ATOM   5248 O O   . PRO B 2 15  ? 10.392  30.499  79.930  1.00 113.01 ?  311 PRO B O   1 
ATOM   5249 C CB  . PRO B 2 15  ? 8.012   32.525  80.547  1.00 105.83 ?  311 PRO B CB  1 
ATOM   5250 C CG  . PRO B 2 15  ? 8.375   33.727  81.319  1.00 100.48 ?  311 PRO B CG  1 
ATOM   5251 C CD  . PRO B 2 15  ? 9.708   33.453  81.959  1.00 102.74 ?  311 PRO B CD  1 
ATOM   5252 N N   . LYS B 2 16  ? 8.500   29.284  80.096  1.00 119.15 ?  312 LYS B N   1 
ATOM   5253 C CA  . LYS B 2 16  ? 9.040   28.180  79.312  1.00 124.46 ?  312 LYS B CA  1 
ATOM   5254 C C   . LYS B 2 16  ? 9.088   28.585  77.843  1.00 123.21 ?  312 LYS B C   1 
ATOM   5255 O O   . LYS B 2 16  ? 8.139   29.184  77.327  1.00 120.04 ?  312 LYS B O   1 
ATOM   5256 C CB  . LYS B 2 16  ? 8.212   26.907  79.521  1.00 126.07 ?  312 LYS B CB  1 
ATOM   5257 C CG  . LYS B 2 16  ? 8.768   25.958  80.619  1.00 130.64 ?  312 LYS B CG  1 
ATOM   5258 C CD  . LYS B 2 16  ? 8.237   26.285  82.033  1.00 131.82 ?  312 LYS B CD  1 
ATOM   5259 C CE  . LYS B 2 16  ? 8.511   25.153  83.044  1.00 131.58 ?  312 LYS B CE  1 
ATOM   5260 N NZ  . LYS B 2 16  ? 7.766   25.332  84.337  1.00 128.11 ?  312 LYS B NZ  1 
ATOM   5261 N N   . GLY B 2 17  ? 10.214  28.297  77.185  1.00 118.10 ?  313 GLY B N   1 
ATOM   5262 C CA  . GLY B 2 17  ? 10.466  28.812  75.850  1.00 115.95 ?  313 GLY B CA  1 
ATOM   5263 C C   . GLY B 2 17  ? 11.395  30.014  75.836  1.00 118.37 ?  313 GLY B C   1 
ATOM   5264 O O   . GLY B 2 17  ? 12.281  30.109  74.976  1.00 119.41 ?  313 GLY B O   1 
ATOM   5265 N N   . MET B 2 18  ? 11.186  30.942  76.776  1.00 107.66 ?  314 MET B N   1 
ATOM   5266 C CA  . MET B 2 18  ? 12.078  32.082  76.947  1.00 104.93 ?  314 MET B CA  1 
ATOM   5267 C C   . MET B 2 18  ? 13.472  31.620  77.360  1.00 101.40 ?  314 MET B C   1 
ATOM   5268 O O   . MET B 2 18  ? 13.627  30.727  78.198  1.00 96.31  ?  314 MET B O   1 
ATOM   5269 C CB  . MET B 2 18  ? 11.512  33.038  78.010  1.00 108.46 ?  314 MET B CB  1 
ATOM   5270 C CG  . MET B 2 18  ? 10.180  33.680  77.646  1.00 95.80  ?  314 MET B CG  1 
ATOM   5271 S SD  . MET B 2 18  ? 10.434  34.932  76.395  1.00 97.12  ?  314 MET B SD  1 
ATOM   5272 C CE  . MET B 2 18  ? 8.809   35.045  75.679  1.00 88.71  ?  314 MET B CE  1 
ATOM   5273 N N   . PHE B 2 19  ? 14.494  32.246  76.783  1.00 97.45  ?  315 PHE B N   1 
ATOM   5274 C CA  . PHE B 2 19  ? 15.870  31.874  77.073  1.00 101.12 ?  315 PHE B CA  1 
ATOM   5275 C C   . PHE B 2 19  ? 16.618  33.067  77.630  1.00 101.83 ?  315 PHE B C   1 
ATOM   5276 O O   . PHE B 2 19  ? 16.625  34.147  77.026  1.00 97.87  ?  315 PHE B O   1 
ATOM   5277 C CB  . PHE B 2 19  ? 16.557  31.316  75.838  1.00 105.16 ?  315 PHE B CB  1 
ATOM   5278 C CG  . PHE B 2 19  ? 16.392  29.845  75.715  1.00 109.50 ?  315 PHE B CG  1 
ATOM   5279 C CD1 . PHE B 2 19  ? 15.218  29.314  75.190  1.00 105.93 ?  315 PHE B CD1 1 
ATOM   5280 C CD2 . PHE B 2 19  ? 17.376  28.983  76.181  1.00 111.76 ?  315 PHE B CD2 1 
ATOM   5281 C CE1 . PHE B 2 19  ? 15.042  27.951  75.100  1.00 102.15 ?  315 PHE B CE1 1 
ATOM   5282 C CE2 . PHE B 2 19  ? 17.212  27.610  76.088  1.00 108.85 ?  315 PHE B CE2 1 
ATOM   5283 C CZ  . PHE B 2 19  ? 16.046  27.094  75.544  1.00 104.48 ?  315 PHE B CZ  1 
ATOM   5284 N N   . LEU B 2 20  ? 17.263  32.846  78.771  1.00 102.85 ?  316 LEU B N   1 
ATOM   5285 C CA  . LEU B 2 20  ? 17.606  33.907  79.698  1.00 105.97 ?  316 LEU B CA  1 
ATOM   5286 C C   . LEU B 2 20  ? 18.619  33.378  80.694  1.00 112.22 ?  316 LEU B C   1 
ATOM   5287 O O   . LEU B 2 20  ? 18.245  32.766  81.701  1.00 114.26 ?  316 LEU B O   1 
ATOM   5288 C CB  . LEU B 2 20  ? 16.349  34.369  80.439  1.00 106.45 ?  316 LEU B CB  1 
ATOM   5289 C CG  . LEU B 2 20  ? 15.252  35.145  79.707  1.00 100.57 ?  316 LEU B CG  1 
ATOM   5290 C CD1 . LEU B 2 20  ? 13.920  35.017  80.429  1.00 96.56  ?  316 LEU B CD1 1 
ATOM   5291 C CD2 . LEU B 2 20  ? 15.660  36.586  79.610  1.00 90.34  ?  316 LEU B CD2 1 
ATOM   5292 N N   . SER B 2 21  ? 19.898  33.568  80.428  1.00 112.63 ?  317 SER B N   1 
ATOM   5293 C CA  . SER B 2 21  ? 20.892  33.186  81.414  1.00 118.65 ?  317 SER B CA  1 
ATOM   5294 C C   . SER B 2 21  ? 21.698  34.412  81.800  1.00 120.68 ?  317 SER B C   1 
ATOM   5295 O O   . SER B 2 21  ? 21.775  35.395  81.051  1.00 116.37 ?  317 SER B O   1 
ATOM   5296 C CB  . SER B 2 21  ? 21.814  32.078  80.899  1.00 120.74 ?  317 SER B CB  1 
ATOM   5297 O OG  . SER B 2 21  ? 22.639  32.563  79.859  1.00 122.14 ?  317 SER B OG  1 
ATOM   5298 N N   . GLN B 2 22  ? 22.276  34.351  83.001  1.00 120.76 ?  318 GLN B N   1 
ATOM   5299 C CA  . GLN B 2 22  ? 23.137  35.439  83.444  1.00 122.77 ?  318 GLN B CA  1 
ATOM   5300 C C   . GLN B 2 22  ? 24.281  35.688  82.467  1.00 122.88 ?  318 GLN B C   1 
ATOM   5301 O O   . GLN B 2 22  ? 24.561  36.846  82.133  1.00 123.45 ?  318 GLN B O   1 
ATOM   5302 C CB  . GLN B 2 22  ? 23.614  35.171  84.880  1.00 123.12 ?  318 GLN B CB  1 
ATOM   5303 C CG  . GLN B 2 22  ? 24.687  36.127  85.444  1.00 128.76 ?  318 GLN B CG  1 
ATOM   5304 C CD  . GLN B 2 22  ? 24.386  37.628  85.293  1.00 132.74 ?  318 GLN B CD  1 
ATOM   5305 O OE1 . GLN B 2 22  ? 25.030  38.300  84.481  1.00 134.09 ?  318 GLN B OE1 1 
ATOM   5306 N NE2 . GLN B 2 22  ? 23.403  38.143  86.034  1.00 122.31 ?  318 GLN B NE2 1 
ATOM   5307 N N   . GLU B 2 23  ? 24.908  34.636  81.936  1.00 124.45 ?  319 GLU B N   1 
ATOM   5308 C CA  . GLU B 2 23  ? 25.965  34.877  80.960  1.00 121.25 ?  319 GLU B CA  1 
ATOM   5309 C C   . GLU B 2 23  ? 25.415  35.567  79.707  1.00 120.41 ?  319 GLU B C   1 
ATOM   5310 O O   . GLU B 2 23  ? 26.049  36.483  79.168  1.00 118.59 ?  319 GLU B O   1 
ATOM   5311 C CB  . GLU B 2 23  ? 26.685  33.564  80.637  1.00 120.10 ?  319 GLU B CB  1 
ATOM   5312 C CG  . GLU B 2 23  ? 25.885  32.550  79.833  1.00 126.38 ?  319 GLU B CG  1 
ATOM   5313 C CD  . GLU B 2 23  ? 26.766  31.528  79.117  1.00 129.53 ?  319 GLU B CD  1 
ATOM   5314 O OE1 . GLU B 2 23  ? 28.010  31.648  79.194  1.00 132.95 ?  319 GLU B OE1 1 
ATOM   5315 O OE2 . GLU B 2 23  ? 26.209  30.614  78.466  1.00 125.00 ?  319 GLU B OE2 1 
ATOM   5316 N N   . ASP B 2 24  ? 24.208  35.189  79.271  1.00 118.88 ?  320 ASP B N   1 
ATOM   5317 C CA  . ASP B 2 24  ? 23.643  35.744  78.042  1.00 115.02 ?  320 ASP B CA  1 
ATOM   5318 C C   . ASP B 2 24  ? 23.437  37.250  78.156  1.00 120.17 ?  320 ASP B C   1 
ATOM   5319 O O   . ASP B 2 24  ? 23.778  38.007  77.236  1.00 118.05 ?  320 ASP B O   1 
ATOM   5320 C CB  . ASP B 2 24  ? 22.307  35.068  77.714  1.00 117.68 ?  320 ASP B CB  1 
ATOM   5321 C CG  . ASP B 2 24  ? 22.457  33.715  77.002  1.00 119.31 ?  320 ASP B CG  1 
ATOM   5322 O OD1 . ASP B 2 24  ? 21.405  33.150  76.615  1.00 117.02 ?  320 ASP B OD1 1 
ATOM   5323 O OD2 . ASP B 2 24  ? 23.595  33.218  76.815  1.00 123.27 ?  320 ASP B OD2 1 
ATOM   5324 N N   . VAL B 2 25  ? 22.865  37.704  79.279  1.00 122.59 ?  321 VAL B N   1 
ATOM   5325 C CA  . VAL B 2 25  ? 22.434  39.097  79.382  1.00 120.21 ?  321 VAL B CA  1 
ATOM   5326 C C   . VAL B 2 25  ? 23.632  40.039  79.329  1.00 120.64 ?  321 VAL B C   1 
ATOM   5327 O O   . VAL B 2 25  ? 23.578  41.096  78.687  1.00 118.75 ?  321 VAL B O   1 
ATOM   5328 C CB  . VAL B 2 25  ? 21.591  39.308  80.655  1.00 113.78 ?  321 VAL B CB  1 
ATOM   5329 C CG1 . VAL B 2 25  ? 20.389  38.372  80.647  1.00 112.50 ?  321 VAL B CG1 1 
ATOM   5330 C CG2 . VAL B 2 25  ? 22.426  39.107  81.908  1.00 117.67 ?  321 VAL B CG2 1 
ATOM   5331 N N   . GLU B 2 26  ? 24.740  39.661  79.975  1.00 121.89 ?  322 GLU B N   1 
ATOM   5332 C CA  . GLU B 2 26  ? 25.914  40.528  79.981  1.00 122.42 ?  322 GLU B CA  1 
ATOM   5333 C C   . GLU B 2 26  ? 26.460  40.734  78.579  1.00 122.29 ?  322 GLU B C   1 
ATOM   5334 O O   . GLU B 2 26  ? 26.873  41.845  78.224  1.00 119.55 ?  322 GLU B O   1 
ATOM   5335 C CB  . GLU B 2 26  ? 27.002  39.952  80.875  1.00 123.25 ?  322 GLU B CB  1 
ATOM   5336 C CG  . GLU B 2 26  ? 26.584  39.668  82.295  1.00 128.16 ?  322 GLU B CG  1 
ATOM   5337 C CD  . GLU B 2 26  ? 27.781  39.321  83.162  1.00 137.74 ?  322 GLU B CD  1 
ATOM   5338 O OE1 . GLU B 2 26  ? 28.913  39.390  82.632  1.00 141.42 ?  322 GLU B OE1 1 
ATOM   5339 O OE2 . GLU B 2 26  ? 27.607  39.013  84.365  1.00 136.56 ?  322 GLU B OE2 1 
ATOM   5340 N N   . ALA B 2 27  ? 26.477  39.671  77.771  1.00 124.52 ?  323 ALA B N   1 
ATOM   5341 C CA  . ALA B 2 27  ? 27.075  39.740  76.443  1.00 124.99 ?  323 ALA B CA  1 
ATOM   5342 C C   . ALA B 2 27  ? 26.287  40.635  75.500  1.00 120.92 ?  323 ALA B C   1 
ATOM   5343 O O   . ALA B 2 27  ? 26.858  41.172  74.544  1.00 124.35 ?  323 ALA B O   1 
ATOM   5344 C CB  . ALA B 2 27  ? 27.199  38.335  75.854  1.00 121.47 ?  323 ALA B CB  1 
ATOM   5345 N N   . VAL B 2 28  ? 24.997  40.744  75.748  1.00 118.22 ?  324 VAL B N   1 
ATOM   5346 C CA  . VAL B 2 28  ? 24.151  41.569  74.851  1.00 119.00 ?  324 VAL B CA  1 
ATOM   5347 C C   . VAL B 2 28  ? 24.014  42.967  75.437  1.00 123.15 ?  324 VAL B C   1 
ATOM   5348 O O   . VAL B 2 28  ? 23.435  43.822  74.776  1.00 119.02 ?  324 VAL B O   1 
ATOM   5349 C CB  . VAL B 2 28  ? 22.779  40.905  74.742  1.00 116.84 ?  324 VAL B CB  1 
ATOM   5350 C CG1 . VAL B 2 28  ? 21.861  41.678  73.824  1.00 115.03 ?  324 VAL B CG1 1 
ATOM   5351 C CG2 . VAL B 2 28  ? 22.918  39.465  74.300  1.00 108.80 ?  324 VAL B CG2 1 
ATOM   5352 N N   . SER B 2 29  ? 24.578  43.177  76.619  1.00 126.66 ?  325 SER B N   1 
ATOM   5353 C CA  . SER B 2 29  ? 24.447  44.454  77.358  1.00 124.25 ?  325 SER B CA  1 
ATOM   5354 C C   . SER B 2 29  ? 25.791  45.171  77.443  1.00 127.58 ?  325 SER B C   1 
ATOM   5355 O O   . SER B 2 29  ? 25.792  46.337  77.810  1.00 131.70 ?  325 SER B O   1 
ATOM   5356 C CB  . SER B 2 29  ? 23.930  44.167  78.730  1.00 119.30 ?  325 SER B CB  1 
ATOM   5357 O OG  . SER B 2 29  ? 24.441  42.937  79.221  1.00 118.89 ?  325 SER B OG  1 
ATOM   5358 N N   . ALA B 2 30  ? 26.877  44.494  77.083  1.00 127.55 ?  326 ALA B N   1 
ATOM   5359 C CA  . ALA B 2 30  ? 28.244  45.055  77.173  1.00 128.52 ?  326 ALA B CA  1 
ATOM   5360 C C   . ALA B 2 30  ? 28.329  46.457  76.576  1.00 129.53 ?  326 ALA B C   1 
ATOM   5361 O O   . ALA B 2 30  ? 28.930  47.310  77.206  1.00 133.77 ?  326 ALA B O   1 
ATOM   5362 C CB  . ALA B 2 30  ? 29.220  44.131  76.510  1.00 128.49 ?  326 ALA B CB  1 
ATOM   5363 N N   . ASN B 2 31  ? 27.791  46.677  75.388  1.00 123.81 ?  327 ASN B N   1 
ATOM   5364 C CA  . ASN B 2 31  ? 27.854  48.051  74.846  1.00 124.46 ?  327 ASN B CA  1 
ATOM   5365 C C   . ASN B 2 31  ? 26.558  48.364  74.115  1.00 123.77 ?  327 ASN B C   1 
ATOM   5366 O O   . ASN B 2 31  ? 25.608  47.613  74.257  1.00 125.42 ?  327 ASN B O   1 
ATOM   5367 C CB  . ASN B 2 31  ? 29.037  48.251  73.913  1.00 127.68 ?  327 ASN B CB  1 
ATOM   5368 C CG  . ASN B 2 31  ? 28.992  47.279  72.765  1.00 128.60 ?  327 ASN B CG  1 
ATOM   5369 O OD1 . ASN B 2 31  ? 28.400  47.557  71.731  1.00 125.06 ?  327 ASN B OD1 1 
ATOM   5370 N ND2 . ASN B 2 31  ? 29.603  46.128  72.960  1.00 127.59 ?  327 ASN B ND2 1 
ATOM   5371 N N   . ALA B 2 32  ? 26.570  49.404  73.295  1.00 121.66 ?  328 ALA B N   1 
ATOM   5372 C CA  . ALA B 2 32  ? 25.332  49.841  72.624  1.00 123.36 ?  328 ALA B CA  1 
ATOM   5373 C C   . ALA B 2 32  ? 25.120  49.089  71.317  1.00 127.86 ?  328 ALA B C   1 
ATOM   5374 O O   . ALA B 2 32  ? 24.067  49.277  70.712  1.00 128.05 ?  328 ALA B O   1 
ATOM   5375 C CB  . ALA B 2 32  ? 25.405  51.320  72.379  1.00 117.39 ?  328 ALA B CB  1 
ATOM   5376 N N   . THR B 2 33  ? 26.082  48.267  70.914  1.00 130.49 ?  329 THR B N   1 
ATOM   5377 C CA  . THR B 2 33  ? 25.970  47.550  69.623  1.00 129.25 ?  329 THR B CA  1 
ATOM   5378 C C   . THR B 2 33  ? 26.177  46.054  69.831  1.00 125.30 ?  329 THR B C   1 
ATOM   5379 O O   . THR B 2 33  ? 25.842  45.299  68.906  1.00 121.57 ?  329 THR B O   1 
ATOM   5380 C CB  . THR B 2 33  ? 26.980  48.113  68.625  1.00 128.59 ?  329 THR B CB  1 
ATOM   5381 O OG1 . THR B 2 33  ? 28.188  48.370  69.340  1.00 126.84 ?  329 THR B OG1 1 
ATOM   5382 C CG2 . THR B 2 33  ? 26.490  49.382  67.969  1.00 118.39 ?  329 THR B CG2 1 
ATOM   5383 N N   . ALA B 2 34  ? 26.624  45.660  71.031  1.00 124.86 ?  330 ALA B N   1 
ATOM   5384 C CA  . ALA B 2 34  ? 26.889  44.254  71.421  1.00 121.29 ?  330 ALA B CA  1 
ATOM   5385 C C   . ALA B 2 34  ? 25.781  43.332  70.923  1.00 118.81 ?  330 ALA B C   1 
ATOM   5386 O O   . ALA B 2 34  ? 26.093  42.330  70.306  1.00 112.83 ?  330 ALA B O   1 
ATOM   5387 C CB  . ALA B 2 34  ? 27.024  44.154  72.911  1.00 119.41 ?  330 ALA B CB  1 
ATOM   5388 N N   . ALA B 2 35  ? 24.538  43.667  71.224  1.00 125.71 ?  331 ALA B N   1 
ATOM   5389 C CA  . ALA B 2 35  ? 23.393  42.894  70.724  1.00 119.43 ?  331 ALA B CA  1 
ATOM   5390 C C   . ALA B 2 35  ? 23.518  42.748  69.215  1.00 114.99 ?  331 ALA B C   1 
ATOM   5391 O O   . ALA B 2 35  ? 23.593  41.627  68.746  1.00 118.35 ?  331 ALA B O   1 
ATOM   5392 C CB  . ALA B 2 35  ? 22.133  43.634  71.060  1.00 122.33 ?  331 ALA B CB  1 
ATOM   5393 N N   . THR B 2 36  ? 23.587  43.847  68.479  1.00 115.66 ?  332 THR B N   1 
ATOM   5394 C CA  . THR B 2 36  ? 23.640  43.670  67.009  1.00 119.07 ?  332 THR B CA  1 
ATOM   5395 C C   . THR B 2 36  ? 24.927  42.959  66.624  1.00 117.20 ?  332 THR B C   1 
ATOM   5396 O O   . THR B 2 36  ? 24.872  42.141  65.725  1.00 116.19 ?  332 THR B O   1 
ATOM   5397 C CB  . THR B 2 36  ? 23.521  44.988  66.252  1.00 117.90 ?  332 THR B CB  1 
ATOM   5398 O OG1 . THR B 2 36  ? 24.272  45.927  67.013  1.00 121.20 ?  332 THR B OG1 1 
ATOM   5399 C CG2 . THR B 2 36  ? 22.086  45.435  66.101  1.00 110.94 ?  332 THR B CG2 1 
ATOM   5400 N N   . THR B 2 37  ? 26.039  43.292  67.262  1.00 117.56 ?  333 THR B N   1 
ATOM   5401 C CA  . THR B 2 37  ? 27.301  42.610  66.913  1.00 115.32 ?  333 THR B CA  1 
ATOM   5402 C C   . THR B 2 37  ? 27.116  41.114  67.128  1.00 118.62 ?  333 THR B C   1 
ATOM   5403 O O   . THR B 2 37  ? 27.278  40.351  66.183  1.00 120.04 ?  333 THR B O   1 
ATOM   5404 C CB  . THR B 2 37  ? 28.448  43.127  67.777  1.00 117.39 ?  333 THR B CB  1 
ATOM   5405 O OG1 . THR B 2 37  ? 28.925  44.304  67.135  1.00 117.90 ?  333 THR B OG1 1 
ATOM   5406 C CG2 . THR B 2 37  ? 29.568  42.127  67.919  1.00 112.50 ?  333 THR B CG2 1 
ATOM   5407 N N   . VAL B 2 38  ? 26.672  40.713  68.310  1.00 118.45 ?  334 VAL B N   1 
ATOM   5408 C CA  . VAL B 2 38  ? 26.518  39.259  68.591  1.00 114.98 ?  334 VAL B CA  1 
ATOM   5409 C C   . VAL B 2 38  ? 25.540  38.619  67.608  1.00 111.39 ?  334 VAL B C   1 
ATOM   5410 O O   . VAL B 2 38  ? 25.753  37.491  67.248  1.00 110.17 ?  334 VAL B O   1 
ATOM   5411 C CB  . VAL B 2 38  ? 26.078  39.014  70.038  1.00 109.47 ?  334 VAL B CB  1 
ATOM   5412 C CG1 . VAL B 2 38  ? 25.103  37.864  70.096  1.00 113.55 ?  334 VAL B CG1 1 
ATOM   5413 C CG2 . VAL B 2 38  ? 27.261  38.738  70.939  1.00 109.99 ?  334 VAL B CG2 1 
ATOM   5414 N N   . LEU B 2 39  ? 24.462  39.289  67.248  1.00 109.34 ?  335 LEU B N   1 
ATOM   5415 C CA  . LEU B 2 39  ? 23.528  38.663  66.297  1.00 110.29 ?  335 LEU B CA  1 
ATOM   5416 C C   . LEU B 2 39  ? 24.197  38.506  64.935  1.00 114.91 ?  335 LEU B C   1 
ATOM   5417 O O   . LEU B 2 39  ? 23.673  37.767  64.127  1.00 115.71 ?  335 LEU B O   1 
ATOM   5418 C CB  . LEU B 2 39  ? 22.299  39.557  66.183  1.00 111.71 ?  335 LEU B CB  1 
ATOM   5419 C CG  . LEU B 2 39  ? 21.360  39.482  67.377  1.00 110.37 ?  335 LEU B CG  1 
ATOM   5420 C CD1 . LEU B 2 39  ? 19.927  39.381  66.911  1.00 108.39 ?  335 LEU B CD1 1 
ATOM   5421 C CD2 . LEU B 2 39  ? 21.712  38.286  68.227  1.00 100.70 ?  335 LEU B CD2 1 
ATOM   5422 N N   . ARG B 2 40  ? 25.291  39.202  64.667  1.00 117.47 ?  336 ARG B N   1 
ATOM   5423 C CA  . ARG B 2 40  ? 25.884  39.028  63.348  1.00 116.71 ?  336 ARG B CA  1 
ATOM   5424 C C   . ARG B 2 40  ? 26.914  37.909  63.342  1.00 116.43 ?  336 ARG B C   1 
ATOM   5425 O O   . ARG B 2 40  ? 26.986  37.155  62.367  1.00 116.74 ?  336 ARG B O   1 
ATOM   5426 C CB  . ARG B 2 40  ? 26.519  40.327  62.864  1.00 117.98 ?  336 ARG B CB  1 
ATOM   5427 C CG  . ARG B 2 40  ? 25.576  41.224  62.114  1.00 120.66 ?  336 ARG B CG  1 
ATOM   5428 C CD  . ARG B 2 40  ? 26.365  42.117  61.179  1.00 131.70 ?  336 ARG B CD  1 
ATOM   5429 N NE  . ARG B 2 40  ? 25.660  43.360  60.883  1.00 140.62 ?  336 ARG B NE  1 
ATOM   5430 C CZ  . ARG B 2 40  ? 26.005  44.546  61.380  1.00 144.75 ?  336 ARG B CZ  1 
ATOM   5431 N NH1 . ARG B 2 40  ? 27.048  44.648  62.201  1.00 134.26 ?  336 ARG B NH1 1 
ATOM   5432 N NH2 . ARG B 2 40  ? 25.310  45.630  61.058  1.00 149.17 ?  336 ARG B NH2 1 
ATOM   5433 N N   . GLN B 2 41  ? 27.692  37.766  64.429  1.00 116.79 ?  337 GLN B N   1 
ATOM   5434 C CA  . GLN B 2 41  ? 28.600  36.627  64.579  1.00 114.64 ?  337 GLN B CA  1 
ATOM   5435 C C   . GLN B 2 41  ? 27.904  35.304  64.332  1.00 111.23 ?  337 GLN B C   1 
ATOM   5436 O O   . GLN B 2 41  ? 28.576  34.293  64.114  1.00 112.33 ?  337 GLN B O   1 
ATOM   5437 C CB  . GLN B 2 41  ? 29.210  36.573  65.991  1.00 117.84 ?  337 GLN B CB  1 
ATOM   5438 C CG  . GLN B 2 41  ? 29.963  37.815  66.411  1.00 129.03 ?  337 GLN B CG  1 
ATOM   5439 C CD  . GLN B 2 41  ? 31.172  38.085  65.539  1.00 131.68 ?  337 GLN B CD  1 
ATOM   5440 O OE1 . GLN B 2 41  ? 31.820  37.150  65.056  1.00 128.55 ?  337 GLN B OE1 1 
ATOM   5441 N NE2 . GLN B 2 41  ? 31.478  39.370  65.322  1.00 130.57 ?  337 GLN B NE2 1 
ATOM   5442 N N   . LEU B 2 42  ? 26.577  35.283  64.394  1.00 110.79 ?  338 LEU B N   1 
ATOM   5443 C CA  . LEU B 2 42  ? 25.800  34.069  64.235  1.00 107.43 ?  338 LEU B CA  1 
ATOM   5444 C C   . LEU B 2 42  ? 25.119  33.997  62.874  1.00 109.13 ?  338 LEU B C   1 
ATOM   5445 O O   . LEU B 2 42  ? 25.094  32.924  62.267  1.00 113.81 ?  338 LEU B O   1 
ATOM   5446 C CB  . LEU B 2 42  ? 24.781  33.961  65.377  1.00 102.02 ?  338 LEU B CB  1 
ATOM   5447 C CG  . LEU B 2 42  ? 25.406  33.835  66.783  1.00 101.78 ?  338 LEU B CG  1 
ATOM   5448 C CD1 . LEU B 2 42  ? 24.487  33.134  67.775  1.00 98.32  ?  338 LEU B CD1 1 
ATOM   5449 C CD2 . LEU B 2 42  ? 26.761  33.134  66.761  1.00 102.41 ?  338 LEU B CD2 1 
ATOM   5450 N N   . ASP B 2 43  ? 24.584  35.112  62.367  1.00 105.32 ?  339 ASP B N   1 
ATOM   5451 C CA  . ASP B 2 43  ? 24.299  35.200  60.938  1.00 107.90 ?  339 ASP B CA  1 
ATOM   5452 C C   . ASP B 2 43  ? 25.478  34.745  60.087  1.00 108.88 ?  339 ASP B C   1 
ATOM   5453 O O   . ASP B 2 43  ? 25.283  34.066  59.073  1.00 106.17 ?  339 ASP B O   1 
ATOM   5454 C CB  . ASP B 2 43  ? 23.875  36.627  60.565  1.00 116.47 ?  339 ASP B CB  1 
ATOM   5455 C CG  . ASP B 2 43  ? 22.399  36.900  60.826  1.00 116.16 ?  339 ASP B CG  1 
ATOM   5456 O OD1 . ASP B 2 43  ? 21.600  35.964  60.607  1.00 117.84 ?  339 ASP B OD1 1 
ATOM   5457 O OD2 . ASP B 2 43  ? 22.034  38.008  61.277  1.00 118.07 ?  339 ASP B OD2 1 
ATOM   5458 N N   . MET B 2 44  ? 26.700  35.108  60.466  1.00 112.37 ?  340 MET B N   1 
ATOM   5459 C CA  . MET B 2 44  ? 27.825  34.731  59.625  1.00 110.53 ?  340 MET B CA  1 
ATOM   5460 C C   . MET B 2 44  ? 28.346  33.340  59.949  1.00 108.36 ?  340 MET B C   1 
ATOM   5461 O O   . MET B 2 44  ? 28.752  32.620  59.033  1.00 114.53 ?  340 MET B O   1 
ATOM   5462 C CB  . MET B 2 44  ? 28.944  35.782  59.704  1.00 108.80 ?  340 MET B CB  1 
ATOM   5463 C CG  . MET B 2 44  ? 28.672  36.980  58.762  1.00 118.32 ?  340 MET B CG  1 
ATOM   5464 S SD  . MET B 2 44  ? 29.632  38.518  59.005  1.00 145.56 ?  340 MET B SD  1 
ATOM   5465 C CE  . MET B 2 44  ? 31.042  38.296  57.907  1.00 127.84 ?  340 MET B CE  1 
ATOM   5466 N N   . GLU B 2 45  ? 28.303  32.918  61.213  1.00 106.24 ?  341 GLU B N   1 
ATOM   5467 C CA  . GLU B 2 45  ? 28.528  31.508  61.527  1.00 106.21 ?  341 GLU B CA  1 
ATOM   5468 C C   . GLU B 2 45  ? 27.481  30.604  60.885  1.00 105.03 ?  341 GLU B C   1 
ATOM   5469 O O   . GLU B 2 45  ? 27.724  29.405  60.726  1.00 102.91 ?  341 GLU B O   1 
ATOM   5470 C CB  . GLU B 2 45  ? 28.539  31.291  63.046  1.00 105.16 ?  341 GLU B CB  1 
ATOM   5471 C CG  . GLU B 2 45  ? 28.769  29.855  63.518  1.00 108.01 ?  341 GLU B CG  1 
ATOM   5472 C CD  . GLU B 2 45  ? 30.239  29.443  63.534  1.00 119.68 ?  341 GLU B CD  1 
ATOM   5473 O OE1 . GLU B 2 45  ? 30.528  28.262  63.214  1.00 121.27 ?  341 GLU B OE1 1 
ATOM   5474 O OE2 . GLU B 2 45  ? 31.101  30.292  63.870  1.00 115.53 ?  341 GLU B OE2 1 
ATOM   5475 N N   . LEU B 2 46  ? 26.327  31.142  60.505  1.00 105.39 ?  342 LEU B N   1 
ATOM   5476 C CA  . LEU B 2 46  ? 25.317  30.276  59.924  1.00 101.16 ?  342 LEU B CA  1 
ATOM   5477 C C   . LEU B 2 46  ? 25.578  30.093  58.433  1.00 104.81 ?  342 LEU B C   1 
ATOM   5478 O O   . LEU B 2 46  ? 25.523  28.968  57.934  1.00 109.76 ?  342 LEU B O   1 
ATOM   5479 C CB  . LEU B 2 46  ? 23.909  30.848  60.123  1.00 104.52 ?  342 LEU B CB  1 
ATOM   5480 C CG  . LEU B 2 46  ? 22.832  29.792  59.818  1.00 105.04 ?  342 LEU B CG  1 
ATOM   5481 C CD1 . LEU B 2 46  ? 22.779  28.752  60.964  1.00 100.49 ?  342 LEU B CD1 1 
ATOM   5482 C CD2 . LEU B 2 46  ? 21.447  30.311  59.429  1.00 102.46 ?  342 LEU B CD2 1 
ATOM   5483 N N   . VAL B 2 47  ? 25.839  31.191  57.709  1.00 103.34 ?  343 VAL B N   1 
ATOM   5484 C CA  . VAL B 2 47  ? 26.323  31.093  56.331  1.00 103.39 ?  343 VAL B CA  1 
ATOM   5485 C C   . VAL B 2 47  ? 27.519  30.166  56.234  1.00 102.21 ?  343 VAL B C   1 
ATOM   5486 O O   . VAL B 2 47  ? 27.565  29.280  55.378  1.00 102.96 ?  343 VAL B O   1 
ATOM   5487 C CB  . VAL B 2 47  ? 26.667  32.480  55.778  1.00 105.99 ?  343 VAL B CB  1 
ATOM   5488 C CG1 . VAL B 2 47  ? 27.488  32.322  54.523  1.00 108.50 ?  343 VAL B CG1 1 
ATOM   5489 C CG2 . VAL B 2 47  ? 25.387  33.198  55.422  1.00 104.48 ?  343 VAL B CG2 1 
ATOM   5490 N N   . SER B 2 48  ? 28.520  30.388  57.086  1.00 103.32 ?  344 SER B N   1 
ATOM   5491 C CA  . SER B 2 48  ? 29.711  29.550  57.138  1.00 104.61 ?  344 SER B CA  1 
ATOM   5492 C C   . SER B 2 48  ? 29.364  28.063  57.053  1.00 105.20 ?  344 SER B C   1 
ATOM   5493 O O   . SER B 2 48  ? 29.782  27.366  56.122  1.00 108.79 ?  344 SER B O   1 
ATOM   5494 C CB  . SER B 2 48  ? 30.492  29.865  58.424  1.00 112.32 ?  344 SER B CB  1 
ATOM   5495 O OG  . SER B 2 48  ? 31.674  29.091  58.559  1.00 118.43 ?  344 SER B OG  1 
ATOM   5496 N N   . VAL B 2 49  ? 28.570  27.570  58.003  1.00 103.94 ?  345 VAL B N   1 
ATOM   5497 C CA  . VAL B 2 49  ? 28.186  26.164  57.991  1.00 101.61 ?  345 VAL B CA  1 
ATOM   5498 C C   . VAL B 2 49  ? 27.313  25.845  56.782  1.00 103.94 ?  345 VAL B C   1 
ATOM   5499 O O   . VAL B 2 49  ? 27.407  24.755  56.209  1.00 106.45 ?  345 VAL B O   1 
ATOM   5500 C CB  . VAL B 2 49  ? 27.477  25.810  59.309  1.00 99.90  ?  345 VAL B CB  1 
ATOM   5501 C CG1 . VAL B 2 49  ? 26.745  24.477  59.200  1.00 102.35 ?  345 VAL B CG1 1 
ATOM   5502 C CG2 . VAL B 2 49  ? 28.474  25.796  60.463  1.00 107.05 ?  345 VAL B CG2 1 
ATOM   5503 N N   . LYS B 2 50  ? 26.480  26.786  56.348  1.00 103.28 ?  346 LYS B N   1 
ATOM   5504 C CA  . LYS B 2 50  ? 25.489  26.458  55.334  1.00 103.61 ?  346 LYS B CA  1 
ATOM   5505 C C   . LYS B 2 50  ? 26.121  26.148  53.978  1.00 104.81 ?  346 LYS B C   1 
ATOM   5506 O O   . LYS B 2 50  ? 25.624  25.274  53.259  1.00 104.51 ?  346 LYS B O   1 
ATOM   5507 C CB  . LYS B 2 50  ? 24.469  27.592  55.213  1.00 106.31 ?  346 LYS B CB  1 
ATOM   5508 C CG  . LYS B 2 50  ? 23.160  27.172  54.551  1.00 115.57 ?  346 LYS B CG  1 
ATOM   5509 C CD  . LYS B 2 50  ? 22.046  28.219  54.691  1.00 120.98 ?  346 LYS B CD  1 
ATOM   5510 C CE  . LYS B 2 50  ? 21.211  27.992  55.956  1.00 115.01 ?  346 LYS B CE  1 
ATOM   5511 N NZ  . LYS B 2 50  ? 19.952  28.790  55.934  1.00 114.33 ?  346 LYS B NZ  1 
ATOM   5512 N N   . ARG B 2 51  ? 27.192  26.837  53.591  1.00 103.76 ?  347 ARG B N   1 
ATOM   5513 C CA  . ARG B 2 51  ? 27.803  26.499  52.313  1.00 109.26 ?  347 ARG B CA  1 
ATOM   5514 C C   . ARG B 2 51  ? 28.937  25.499  52.457  1.00 108.13 ?  347 ARG B C   1 
ATOM   5515 O O   . ARG B 2 51  ? 29.339  24.890  51.460  1.00 114.42 ?  347 ARG B O   1 
ATOM   5516 C CB  . ARG B 2 51  ? 28.296  27.751  51.572  1.00 110.79 ?  347 ARG B CB  1 
ATOM   5517 C CG  . ARG B 2 51  ? 29.322  28.575  52.273  1.00 101.67 ?  347 ARG B CG  1 
ATOM   5518 C CD  . ARG B 2 51  ? 29.997  29.517  51.275  1.00 113.07 ?  347 ARG B CD  1 
ATOM   5519 N NE  . ARG B 2 51  ? 30.273  30.810  51.894  1.00 114.82 ?  347 ARG B NE  1 
ATOM   5520 C CZ  . ARG B 2 51  ? 31.091  30.977  52.932  1.00 118.54 ?  347 ARG B CZ  1 
ATOM   5521 N NH1 . ARG B 2 51  ? 31.736  29.930  53.450  1.00 118.47 ?  347 ARG B NH1 1 
ATOM   5522 N NH2 . ARG B 2 51  ? 31.269  32.188  53.454  1.00 111.57 ?  347 ARG B NH2 1 
ATOM   5523 N N   . GLN B 2 52  ? 29.451  25.311  53.669  1.00 99.85  ?  348 GLN B N   1 
ATOM   5524 C CA  . GLN B 2 52  ? 30.219  24.112  53.948  1.00 100.01 ?  348 GLN B CA  1 
ATOM   5525 C C   . GLN B 2 52  ? 29.341  22.883  53.758  1.00 104.44 ?  348 GLN B C   1 
ATOM   5526 O O   . GLN B 2 52  ? 29.814  21.840  53.295  1.00 105.90 ?  348 GLN B O   1 
ATOM   5527 C CB  . GLN B 2 52  ? 30.767  24.175  55.362  1.00 103.67 ?  348 GLN B CB  1 
ATOM   5528 C CG  . GLN B 2 52  ? 31.425  22.917  55.864  1.00 109.45 ?  348 GLN B CG  1 
ATOM   5529 C CD  . GLN B 2 52  ? 31.775  23.017  57.355  1.00 118.12 ?  348 GLN B CD  1 
ATOM   5530 O OE1 . GLN B 2 52  ? 32.287  22.066  57.954  1.00 123.75 ?  348 GLN B OE1 1 
ATOM   5531 N NE2 . GLN B 2 52  ? 31.507  24.182  57.950  1.00 116.93 ?  348 GLN B NE2 1 
ATOM   5532 N N   . ILE B 2 53  ? 28.051  22.995  54.115  1.00 107.55 ?  349 ILE B N   1 
ATOM   5533 C CA  . ILE B 2 53  ? 27.076  21.934  53.848  1.00 104.51 ?  349 ILE B CA  1 
ATOM   5534 C C   . ILE B 2 53  ? 27.027  21.629  52.360  1.00 104.93 ?  349 ILE B C   1 
ATOM   5535 O O   . ILE B 2 53  ? 27.261  20.496  51.936  1.00 109.07 ?  349 ILE B O   1 
ATOM   5536 C CB  . ILE B 2 53  ? 25.681  22.332  54.360  1.00 104.61 ?  349 ILE B CB  1 
ATOM   5537 C CG1 . ILE B 2 53  ? 25.547  22.232  55.876  1.00 98.96  ?  349 ILE B CG1 1 
ATOM   5538 C CG2 . ILE B 2 53  ? 24.625  21.430  53.741  1.00 102.42 ?  349 ILE B CG2 1 
ATOM   5539 C CD1 . ILE B 2 53  ? 25.367  20.861  56.329  1.00 103.05 ?  349 ILE B CD1 1 
ATOM   5540 N N   . GLN B 2 54  ? 26.703  22.633  51.545  1.00 102.66 ?  350 GLN B N   1 
ATOM   5541 C CA  . GLN B 2 54  ? 26.558  22.375  50.121  1.00 106.67 ?  350 GLN B CA  1 
ATOM   5542 C C   . GLN B 2 54  ? 27.881  21.986  49.467  1.00 107.08 ?  350 GLN B C   1 
ATOM   5543 O O   . GLN B 2 54  ? 27.882  21.418  48.369  1.00 107.62 ?  350 GLN B O   1 
ATOM   5544 C CB  . GLN B 2 54  ? 25.941  23.582  49.415  1.00 102.82 ?  350 GLN B CB  1 
ATOM   5545 C CG  . GLN B 2 54  ? 25.589  23.248  47.979  1.00 120.26 ?  350 GLN B CG  1 
ATOM   5546 C CD  . GLN B 2 54  ? 24.904  24.363  47.233  1.00 130.31 ?  350 GLN B CD  1 
ATOM   5547 O OE1 . GLN B 2 54  ? 24.356  25.289  47.835  1.00 133.60 ?  350 GLN B OE1 1 
ATOM   5548 N NE2 . GLN B 2 54  ? 24.943  24.288  45.901  1.00 130.43 ?  350 GLN B NE2 1 
ATOM   5549 N N   . ASN B 2 55  ? 28.999  22.250  50.124  1.00 104.46 ?  351 ASN B N   1 
ATOM   5550 C CA  . ASN B 2 55  ? 30.277  21.722  49.682  1.00 101.88 ?  351 ASN B CA  1 
ATOM   5551 C C   . ASN B 2 55  ? 30.339  20.203  49.765  1.00 102.97 ?  351 ASN B C   1 
ATOM   5552 O O   . ASN B 2 55  ? 30.420  19.517  48.745  1.00 105.32 ?  351 ASN B O   1 
ATOM   5553 C CB  . ASN B 2 55  ? 31.401  22.304  50.521  1.00 108.29 ?  351 ASN B CB  1 
ATOM   5554 C CG  . ASN B 2 55  ? 32.680  22.294  49.795  1.00 109.94 ?  351 ASN B CG  1 
ATOM   5555 O OD1 . ASN B 2 55  ? 32.718  22.716  48.650  1.00 107.26 ?  351 ASN B OD1 1 
ATOM   5556 N ND2 . ASN B 2 55  ? 33.747  21.797  50.428  1.00 109.94 ?  351 ASN B ND2 1 
ATOM   5557 N N   . ILE B 2 56  ? 30.327  19.676  50.987  1.00 102.81 ?  352 ILE B N   1 
ATOM   5558 C CA  . ILE B 2 56  ? 30.433  18.241  51.201  1.00 98.56  ?  352 ILE B CA  1 
ATOM   5559 C C   . ILE B 2 56  ? 29.248  17.502  50.596  1.00 100.87 ?  352 ILE B C   1 
ATOM   5560 O O   . ILE B 2 56  ? 29.386  16.365  50.140  1.00 104.46 ?  352 ILE B O   1 
ATOM   5561 C CB  . ILE B 2 56  ? 30.568  17.985  52.705  1.00 93.72  ?  352 ILE B CB  1 
ATOM   5562 C CG1 . ILE B 2 56  ? 31.818  18.705  53.196  1.00 105.10 ?  352 ILE B CG1 1 
ATOM   5563 C CG2 . ILE B 2 56  ? 30.662  16.505  52.982  1.00 97.25  ?  352 ILE B CG2 1 
ATOM   5564 C CD1 . ILE B 2 56  ? 31.908  18.817  54.686  1.00 118.45 ?  352 ILE B CD1 1 
ATOM   5565 N N   . LYS B 2 57  ? 28.072  18.129  50.562  1.00 103.82 ?  353 LYS B N   1 
ATOM   5566 C CA  . LYS B 2 57  ? 26.927  17.540  49.872  1.00 103.23 ?  353 LYS B CA  1 
ATOM   5567 C C   . LYS B 2 57  ? 27.234  17.285  48.407  1.00 103.44 ?  353 LYS B C   1 
ATOM   5568 O O   . LYS B 2 57  ? 26.603  16.425  47.782  1.00 107.13 ?  353 LYS B O   1 
ATOM   5569 C CB  . LYS B 2 57  ? 25.708  18.469  50.015  1.00 107.03 ?  353 LYS B CB  1 
ATOM   5570 C CG  . LYS B 2 57  ? 24.357  17.897  49.585  1.00 113.43 ?  353 LYS B CG  1 
ATOM   5571 C CD  . LYS B 2 57  ? 23.206  18.867  49.883  1.00 115.89 ?  353 LYS B CD  1 
ATOM   5572 C CE  . LYS B 2 57  ? 21.871  18.315  49.377  1.00 123.96 ?  353 LYS B CE  1 
ATOM   5573 N NZ  . LYS B 2 57  ? 20.701  19.174  49.717  1.00 119.92 ?  353 LYS B NZ  1 
ATOM   5574 N N   . GLN B 2 58  ? 28.217  17.989  47.866  1.00 103.28 ?  354 GLN B N   1 
ATOM   5575 C CA  . GLN B 2 58  ? 28.534  17.997  46.447  1.00 105.56 ?  354 GLN B CA  1 
ATOM   5576 C C   . GLN B 2 58  ? 29.818  17.234  46.134  1.00 106.22 ?  354 GLN B C   1 
ATOM   5577 O O   . GLN B 2 58  ? 29.938  16.654  45.054  1.00 103.97 ?  354 GLN B O   1 
ATOM   5578 C CB  . GLN B 2 58  ? 28.602  19.468  46.005  1.00 103.77 ?  354 GLN B CB  1 
ATOM   5579 C CG  . GLN B 2 58  ? 28.912  19.863  44.602  1.00 109.10 ?  354 GLN B CG  1 
ATOM   5580 C CD  . GLN B 2 58  ? 28.316  21.261  44.298  1.00 121.04 ?  354 GLN B CD  1 
ATOM   5581 O OE1 . GLN B 2 58  ? 28.988  22.288  44.453  1.00 121.77 ?  354 GLN B OE1 1 
ATOM   5582 N NE2 . GLN B 2 58  ? 27.074  21.285  43.813  1.00 122.95 ?  354 GLN B NE2 1 
ATOM   5583 N N   . THR B 2 59  ? 30.745  17.187  47.093  1.00 103.93 ?  355 THR B N   1 
ATOM   5584 C CA  . THR B 2 59  ? 31.766  16.146  47.136  1.00 99.39  ?  355 THR B CA  1 
ATOM   5585 C C   . THR B 2 59  ? 31.151  14.756  47.241  1.00 101.63 ?  355 THR B C   1 
ATOM   5586 O O   . THR B 2 59  ? 31.526  13.842  46.497  1.00 103.01 ?  355 THR B O   1 
ATOM   5587 C CB  . THR B 2 59  ? 32.717  16.410  48.309  1.00 100.99 ?  355 THR B CB  1 
ATOM   5588 O OG1 . THR B 2 59  ? 33.484  17.593  48.054  1.00 103.71 ?  355 THR B OG1 1 
ATOM   5589 C CG2 . THR B 2 59  ? 33.620  15.214  48.612  1.00 97.69  ?  355 THR B CG2 1 
ATOM   5590 N N   . ASN B 2 60  ? 30.223  14.566  48.180  1.00 102.94 ?  356 ASN B N   1 
ATOM   5591 C CA  . ASN B 2 60  ? 29.613  13.255  48.374  1.00 97.11  ?  356 ASN B CA  1 
ATOM   5592 C C   . ASN B 2 60  ? 28.699  12.852  47.227  1.00 102.20 ?  356 ASN B C   1 
ATOM   5593 O O   . ASN B 2 60  ? 28.328  11.680  47.139  1.00 107.33 ?  356 ASN B O   1 
ATOM   5594 C CB  . ASN B 2 60  ? 28.822  13.208  49.682  1.00 92.24  ?  356 ASN B CB  1 
ATOM   5595 C CG  . ASN B 2 60  ? 29.711  13.028  50.891  1.00 100.82 ?  356 ASN B CG  1 
ATOM   5596 O OD1 . ASN B 2 60  ? 30.919  13.260  50.826  1.00 101.15 ?  356 ASN B OD1 1 
ATOM   5597 N ND2 . ASN B 2 60  ? 29.123  12.589  52.001  1.00 101.34 ?  356 ASN B ND2 1 
ATOM   5598 N N   . SER B 2 61  ? 28.307  13.784  46.363  1.00 103.48 ?  357 SER B N   1 
ATOM   5599 C CA  . SER B 2 61  ? 27.570  13.401  45.166  1.00 104.11 ?  357 SER B CA  1 
ATOM   5600 C C   . SER B 2 61  ? 28.498  12.884  44.078  1.00 107.93 ?  357 SER B C   1 
ATOM   5601 O O   . SER B 2 61  ? 28.073  12.095  43.227  1.00 108.90 ?  357 SER B O   1 
ATOM   5602 C CB  . SER B 2 61  ? 26.769  14.586  44.638  1.00 102.32 ?  357 SER B CB  1 
ATOM   5603 O OG  . SER B 2 61  ? 26.450  14.389  43.274  1.00 102.09 ?  357 SER B OG  1 
ATOM   5604 N N   . ALA B 2 62  ? 29.753  13.339  44.076  1.00 106.73 ?  358 ALA B N   1 
ATOM   5605 C CA  . ALA B 2 62  ? 30.759  12.773  43.187  1.00 102.48 ?  358 ALA B CA  1 
ATOM   5606 C C   . ALA B 2 62  ? 31.044  11.319  43.545  1.00 107.35 ?  358 ALA B C   1 
ATOM   5607 O O   . ALA B 2 62  ? 31.061  10.444  42.672  1.00 108.67 ?  358 ALA B O   1 
ATOM   5608 C CB  . ALA B 2 62  ? 32.038  13.603  43.258  1.00 96.93  ?  358 ALA B CB  1 
ATOM   5609 N N   . LEU B 2 63  ? 31.263  11.042  44.835  1.00 104.27 ?  359 LEU B N   1 
ATOM   5610 C CA  . LEU B 2 63  ? 31.572  9.682   45.260  1.00 103.84 ?  359 LEU B CA  1 
ATOM   5611 C C   . LEU B 2 63  ? 30.428  8.724   44.966  1.00 108.61 ?  359 LEU B C   1 
ATOM   5612 O O   . LEU B 2 63  ? 30.659  7.521   44.809  1.00 112.06 ?  359 LEU B O   1 
ATOM   5613 C CB  . LEU B 2 63  ? 31.909  9.634   46.753  1.00 101.14 ?  359 LEU B CB  1 
ATOM   5614 C CG  . LEU B 2 63  ? 32.990  10.587  47.267  1.00 103.54 ?  359 LEU B CG  1 
ATOM   5615 C CD1 . LEU B 2 63  ? 33.389  10.242  48.697  1.00 101.31 ?  359 LEU B CD1 1 
ATOM   5616 C CD2 . LEU B 2 63  ? 34.199  10.632  46.341  1.00 106.73 ?  359 LEU B CD2 1 
ATOM   5617 N N   . LYS B 2 64  ? 29.192  9.220   44.895  1.00 109.83 ?  360 LYS B N   1 
ATOM   5618 C CA  . LYS B 2 64  ? 28.082  8.316   44.611  1.00 111.83 ?  360 LYS B CA  1 
ATOM   5619 C C   . LYS B 2 64  ? 28.105  7.851   43.157  1.00 114.47 ?  360 LYS B C   1 
ATOM   5620 O O   . LYS B 2 64  ? 27.742  6.703   42.868  1.00 117.36 ?  360 LYS B O   1 
ATOM   5621 C CB  . LYS B 2 64  ? 26.743  8.974   44.962  1.00 113.82 ?  360 LYS B CB  1 
ATOM   5622 C CG  . LYS B 2 64  ? 26.295  8.822   46.432  1.00 110.67 ?  360 LYS B CG  1 
ATOM   5623 C CD  . LYS B 2 64  ? 25.209  9.861   46.786  1.00 118.45 ?  360 LYS B CD  1 
ATOM   5624 C CE  . LYS B 2 64  ? 23.941  9.669   45.943  1.00 122.95 ?  360 LYS B CE  1 
ATOM   5625 N NZ  . LYS B 2 64  ? 22.903  10.725  46.157  1.00 116.72 ?  360 LYS B NZ  1 
ATOM   5626 N N   . GLU B 2 65  ? 28.539  8.714   42.227  1.00 113.82 ?  361 GLU B N   1 
ATOM   5627 C CA  . GLU B 2 65  ? 28.664  8.279   40.834  1.00 116.64 ?  361 GLU B CA  1 
ATOM   5628 C C   . GLU B 2 65  ? 29.741  7.209   40.684  1.00 117.98 ?  361 GLU B C   1 
ATOM   5629 O O   . GLU B 2 65  ? 29.510  6.173   40.045  1.00 121.27 ?  361 GLU B O   1 
ATOM   5630 C CB  . GLU B 2 65  ? 28.964  9.453   39.900  1.00 115.24 ?  361 GLU B CB  1 
ATOM   5631 C CG  . GLU B 2 65  ? 27.815  10.410  39.631  1.00 120.17 ?  361 GLU B CG  1 
ATOM   5632 C CD  . GLU B 2 65  ? 27.976  11.122  38.287  1.00 132.19 ?  361 GLU B CD  1 
ATOM   5633 O OE1 . GLU B 2 65  ? 28.914  10.766  37.539  1.00 135.70 ?  361 GLU B OE1 1 
ATOM   5634 O OE2 . GLU B 2 65  ? 27.186  12.047  37.983  1.00 135.22 ?  361 GLU B OE2 1 
ATOM   5635 N N   . LYS B 2 66  ? 30.922  7.436   41.270  1.00 112.58 ?  362 LYS B N   1 
ATOM   5636 C CA  . LYS B 2 66  ? 32.008  6.466   41.170  1.00 111.72 ?  362 LYS B CA  1 
ATOM   5637 C C   . LYS B 2 66  ? 31.614  5.076   41.664  1.00 112.34 ?  362 LYS B C   1 
ATOM   5638 O O   . LYS B 2 66  ? 32.312  4.106   41.348  1.00 117.16 ?  362 LYS B O   1 
ATOM   5639 C CB  . LYS B 2 66  ? 33.244  6.977   41.923  1.00 102.45 ?  362 LYS B CB  1 
ATOM   5640 C CG  . LYS B 2 66  ? 34.034  8.017   41.130  1.00 101.91 ?  362 LYS B CG  1 
ATOM   5641 C CD  . LYS B 2 66  ? 34.952  8.852   42.006  1.00 104.39 ?  362 LYS B CD  1 
ATOM   5642 C CE  . LYS B 2 66  ? 35.708  9.909   41.185  1.00 113.38 ?  362 LYS B CE  1 
ATOM   5643 N NZ  . LYS B 2 66  ? 35.511  11.316  41.674  1.00 111.52 ?  362 LYS B NZ  1 
ATOM   5644 N N   . LEU B 2 67  ? 30.501  4.953   42.387  1.00 107.99 ?  363 LEU B N   1 
ATOM   5645 C CA  . LEU B 2 67  ? 29.954  3.680   42.841  1.00 109.78 ?  363 LEU B CA  1 
ATOM   5646 C C   . LEU B 2 67  ? 28.752  3.204   42.029  1.00 116.36 ?  363 LEU B C   1 
ATOM   5647 O O   . LEU B 2 67  ? 27.954  2.403   42.535  1.00 113.75 ?  363 LEU B O   1 
ATOM   5648 C CB  . LEU B 2 67  ? 29.595  3.784   44.320  1.00 104.12 ?  363 LEU B CB  1 
ATOM   5649 C CG  . LEU B 2 67  ? 30.714  3.407   45.271  1.00 100.14 ?  363 LEU B CG  1 
ATOM   5650 C CD1 . LEU B 2 67  ? 31.902  4.252   45.060  1.00 100.86 ?  363 LEU B CD1 1 
ATOM   5651 C CD2 . LEU B 2 67  ? 30.171  3.668   46.667  1.00 97.45  ?  363 LEU B CD2 1 
ATOM   5652 N N   . ASP B 2 68  ? 28.619  3.648   40.778  1.00 119.30 ?  364 ASP B N   1 
ATOM   5653 C CA  . ASP B 2 68  ? 27.527  3.163   39.940  1.00 124.78 ?  364 ASP B CA  1 
ATOM   5654 C C   . ASP B 2 68  ? 27.655  1.654   39.722  1.00 127.48 ?  364 ASP B C   1 
ATOM   5655 O O   . ASP B 2 68  ? 28.757  1.110   39.587  1.00 127.48 ?  364 ASP B O   1 
ATOM   5656 C CB  . ASP B 2 68  ? 27.489  3.891   38.584  1.00 127.37 ?  364 ASP B CB  1 
ATOM   5657 C CG  . ASP B 2 68  ? 28.682  3.546   37.671  1.00 132.97 ?  364 ASP B CG  1 
ATOM   5658 O OD1 . ASP B 2 68  ? 29.772  3.173   38.168  1.00 130.58 ?  364 ASP B OD1 1 
ATOM   5659 O OD2 . ASP B 2 68  ? 28.511  3.628   36.431  1.00 130.94 ?  364 ASP B OD2 1 
ATOM   5660 N N   . GLY B 2 69  ? 26.507  0.977   39.690  1.00 127.18 ?  365 GLY B N   1 
ATOM   5661 C CA  . GLY B 2 69  ? 26.474  -0.466  39.584  1.00 123.71 ?  365 GLY B CA  1 
ATOM   5662 C C   . GLY B 2 69  ? 26.837  -1.212  40.849  1.00 119.72 ?  365 GLY B C   1 
ATOM   5663 O O   . GLY B 2 69  ? 26.731  -2.443  40.869  1.00 120.50 ?  365 GLY B O   1 
ATOM   5664 N N   . GLY B 2 70  ? 27.252  -0.513  41.903  1.00 116.37 ?  366 GLY B N   1 
ATOM   5665 C CA  . GLY B 2 70  ? 27.637  -1.194  43.127  1.00 114.40 ?  366 GLY B CA  1 
ATOM   5666 C C   . GLY B 2 70  ? 28.816  -2.117  42.889  1.00 111.22 ?  366 GLY B C   1 
ATOM   5667 O O   . GLY B 2 70  ? 29.814  -1.740  42.258  1.00 105.79 ?  366 GLY B O   1 
ATOM   5668 N N   . ILE B 2 71  ? 28.702  -3.345  43.405  1.00 108.41 ?  367 ILE B N   1 
ATOM   5669 C CA  . ILE B 2 71  ? 29.711  -4.379  43.194  1.00 107.53 ?  367 ILE B CA  1 
ATOM   5670 C C   . ILE B 2 71  ? 29.055  -5.623  42.608  1.00 111.53 ?  367 ILE B C   1 
ATOM   5671 O O   . ILE B 2 71  ? 29.400  -6.749  42.980  1.00 114.18 ?  367 ILE B O   1 
ATOM   5672 C CB  . ILE B 2 71  ? 30.456  -4.729  44.498  1.00 99.72  ?  367 ILE B CB  1 
ATOM   5673 C CG1 . ILE B 2 71  ? 29.485  -5.170  45.596  1.00 96.39  ?  367 ILE B CG1 1 
ATOM   5674 C CG2 . ILE B 2 71  ? 31.329  -3.576  44.952  1.00 97.24  ?  367 ILE B CG2 1 
ATOM   5675 C CD1 . ILE B 2 71  ? 30.173  -5.834  46.754  1.00 94.39  ?  367 ILE B CD1 1 
ATOM   5676 N N   . GLU B 2 72  ? 28.120  -5.442  41.679  1.00 113.39 ?  368 GLU B N   1 
ATOM   5677 C CA  . GLU B 2 72  ? 27.330  -6.595  41.254  1.00 116.05 ?  368 GLU B CA  1 
ATOM   5678 C C   . GLU B 2 72  ? 27.944  -7.406  40.114  1.00 114.45 ?  368 GLU B C   1 
ATOM   5679 O O   . GLU B 2 72  ? 27.776  -8.633  40.099  1.00 112.50 ?  368 GLU B O   1 
ATOM   5680 C CB  . GLU B 2 72  ? 25.906  -6.160  40.900  1.00 116.21 ?  368 GLU B CB  1 
ATOM   5681 C CG  . GLU B 2 72  ? 25.077  -5.817  42.148  1.00 121.70 ?  368 GLU B CG  1 
ATOM   5682 C CD  . GLU B 2 72  ? 25.401  -6.719  43.355  1.00 121.56 ?  368 GLU B CD  1 
ATOM   5683 O OE1 . GLU B 2 72  ? 26.116  -6.260  44.279  1.00 120.81 ?  368 GLU B OE1 1 
ATOM   5684 O OE2 . GLU B 2 72  ? 24.940  -7.884  43.389  1.00 120.54 ?  368 GLU B OE2 1 
ATOM   5685 N N   . PRO B 2 73  ? 28.660  -6.806  39.152  1.00 115.42 ?  369 PRO B N   1 
ATOM   5686 C CA  . PRO B 2 73  ? 29.410  -7.638  38.195  1.00 116.20 ?  369 PRO B CA  1 
ATOM   5687 C C   . PRO B 2 73  ? 30.548  -8.426  38.833  1.00 111.11 ?  369 PRO B C   1 
ATOM   5688 O O   . PRO B 2 73  ? 31.260  -9.144  38.122  1.00 111.06 ?  369 PRO B O   1 
ATOM   5689 C CB  . PRO B 2 73  ? 29.959  -6.613  37.181  1.00 115.75 ?  369 PRO B CB  1 
ATOM   5690 C CG  . PRO B 2 73  ? 29.111  -5.405  37.342  1.00 116.08 ?  369 PRO B CG  1 
ATOM   5691 C CD  . PRO B 2 73  ? 28.712  -5.378  38.783  1.00 113.25 ?  369 PRO B CD  1 
ATOM   5692 N N   . TYR B 2 74  ? 30.720  -8.327  40.151  1.00 104.99 ?  370 TYR B N   1 
ATOM   5693 C CA  . TYR B 2 74  ? 31.939  -8.718  40.828  1.00 100.86 ?  370 TYR B CA  1 
ATOM   5694 C C   . TYR B 2 74  ? 31.691  -9.782  41.871  1.00 104.85 ?  370 TYR B C   1 
ATOM   5695 O O   . TYR B 2 74  ? 32.651  -10.313 42.444  1.00 102.57 ?  370 TYR B O   1 
ATOM   5696 C CB  . TYR B 2 74  ? 32.575  -7.496  41.502  1.00 106.48 ?  370 TYR B CB  1 
ATOM   5697 C CG  . TYR B 2 74  ? 33.059  -6.456  40.519  1.00 111.20 ?  370 TYR B CG  1 
ATOM   5698 C CD1 . TYR B 2 74  ? 34.395  -6.120  40.432  1.00 110.03 ?  370 TYR B CD1 1 
ATOM   5699 C CD2 . TYR B 2 74  ? 32.172  -5.824  39.650  1.00 114.44 ?  370 TYR B CD2 1 
ATOM   5700 C CE1 . TYR B 2 74  ? 34.818  -5.172  39.517  1.00 108.80 ?  370 TYR B CE1 1 
ATOM   5701 C CE2 . TYR B 2 74  ? 32.594  -4.894  38.734  1.00 110.45 ?  370 TYR B CE2 1 
ATOM   5702 C CZ  . TYR B 2 74  ? 33.916  -4.570  38.682  1.00 109.24 ?  370 TYR B CZ  1 
ATOM   5703 O OH  . TYR B 2 74  ? 34.331  -3.645  37.769  1.00 112.38 ?  370 TYR B OH  1 
ATOM   5704 N N   . ARG B 2 75  ? 30.435  -10.090 42.146  1.00 109.24 ?  371 ARG B N   1 
ATOM   5705 C CA  . ARG B 2 75  ? 30.107  -11.125 43.099  1.00 110.77 ?  371 ARG B CA  1 
ATOM   5706 C C   . ARG B 2 75  ? 30.239  -12.489 42.457  1.00 109.78 ?  371 ARG B C   1 
ATOM   5707 O O   . ARG B 2 75  ? 30.119  -12.648 41.237  1.00 104.46 ?  371 ARG B O   1 
ATOM   5708 C CB  . ARG B 2 75  ? 28.687  -10.954 43.617  1.00 112.64 ?  371 ARG B CB  1 
ATOM   5709 C CG  . ARG B 2 75  ? 28.569  -9.941  44.682  1.00 109.50 ?  371 ARG B CG  1 
ATOM   5710 C CD  . ARG B 2 75  ? 27.596  -10.423 45.712  1.00 121.30 ?  371 ARG B CD  1 
ATOM   5711 N NE  . ARG B 2 75  ? 27.460  -9.441  46.776  1.00 122.90 ?  371 ARG B NE  1 
ATOM   5712 C CZ  . ARG B 2 75  ? 26.500  -8.529  46.799  1.00 120.56 ?  371 ARG B CZ  1 
ATOM   5713 N NH1 . ARG B 2 75  ? 25.614  -8.487  45.813  1.00 120.83 ?  371 ARG B NH1 1 
ATOM   5714 N NH2 . ARG B 2 75  ? 26.429  -7.664  47.794  1.00 119.40 ?  371 ARG B NH2 1 
ATOM   5715 N N   . LEU B 2 76  ? 30.478  -13.476 43.310  1.00 110.93 ?  372 LEU B N   1 
ATOM   5716 C CA  . LEU B 2 76  ? 30.618  -14.872 42.988  1.00 112.15 ?  372 LEU B CA  1 
ATOM   5717 C C   . LEU B 2 76  ? 29.521  -15.653 43.684  1.00 117.87 ?  372 LEU B C   1 
ATOM   5718 O O   . LEU B 2 76  ? 29.191  -15.357 44.837  1.00 119.71 ?  372 LEU B O   1 
ATOM   5719 C CB  . LEU B 2 76  ? 31.979  -15.399 43.444  1.00 108.89 ?  372 LEU B CB  1 
ATOM   5720 C CG  . LEU B 2 76  ? 33.138  -14.562 42.917  1.00 104.65 ?  372 LEU B CG  1 
ATOM   5721 C CD1 . LEU B 2 76  ? 34.445  -15.027 43.525  1.00 95.62  ?  372 LEU B CD1 1 
ATOM   5722 C CD2 . LEU B 2 76  ? 33.184  -14.605 41.383  1.00 98.02  ?  372 LEU B CD2 1 
ATOM   5723 N N   . PRO B 2 77  ? 28.953  -16.644 43.026  1.00 118.89 ?  373 PRO B N   1 
ATOM   5724 C CA  . PRO B 2 77  ? 27.906  -17.453 43.658  1.00 121.73 ?  373 PRO B CA  1 
ATOM   5725 C C   . PRO B 2 77  ? 28.368  -18.139 44.934  1.00 126.35 ?  373 PRO B C   1 
ATOM   5726 O O   . PRO B 2 77  ? 29.547  -18.081 45.306  1.00 125.74 ?  373 PRO B O   1 
ATOM   5727 C CB  . PRO B 2 77  ? 27.550  -18.471 42.570  1.00 121.84 ?  373 PRO B CB  1 
ATOM   5728 C CG  . PRO B 2 77  ? 28.716  -18.453 41.629  1.00 116.50 ?  373 PRO B CG  1 
ATOM   5729 C CD  . PRO B 2 77  ? 29.229  -17.062 41.647  1.00 113.31 ?  373 PRO B CD  1 
ATOM   5730 N N   . GLU B 2 78  ? 27.431  -18.803 45.603  1.00 135.59 ?  374 GLU B N   1 
ATOM   5731 C CA  . GLU B 2 78  ? 27.637  -19.348 46.939  1.00 145.08 ?  374 GLU B CA  1 
ATOM   5732 C C   . GLU B 2 78  ? 27.974  -20.836 46.869  1.00 147.65 ?  374 GLU B C   1 
ATOM   5733 O O   . GLU B 2 78  ? 27.211  -21.626 46.299  1.00 144.25 ?  374 GLU B O   1 
ATOM   5734 C CB  . GLU B 2 78  ? 26.385  -19.129 47.796  1.00 149.64 ?  374 GLU B CB  1 
ATOM   5735 C CG  . GLU B 2 78  ? 26.581  -19.396 49.283  1.00 154.19 ?  374 GLU B CG  1 
ATOM   5736 C CD  . GLU B 2 78  ? 27.645  -18.501 49.907  1.00 158.50 ?  374 GLU B CD  1 
ATOM   5737 O OE1 . GLU B 2 78  ? 28.830  -18.911 49.914  1.00 159.45 ?  374 GLU B OE1 1 
ATOM   5738 O OE2 . GLU B 2 78  ? 27.295  -17.400 50.397  1.00 151.89 ?  374 GLU B OE2 1 
ATOM   5739 N N   . VAL B 2 79  ? 29.112  -21.212 47.462  1.00 148.91 ?  375 VAL B N   1 
ATOM   5740 C CA  . VAL B 2 79  ? 29.528  -22.609 47.556  1.00 149.34 ?  375 VAL B CA  1 
ATOM   5741 C C   . VAL B 2 79  ? 28.789  -23.261 48.725  1.00 151.50 ?  375 VAL B C   1 
ATOM   5742 O O   . VAL B 2 79  ? 29.288  -23.286 49.859  1.00 151.42 ?  375 VAL B O   1 
ATOM   5743 C CB  . VAL B 2 79  ? 31.059  -22.731 47.721  1.00 147.75 ?  375 VAL B CB  1 
ATOM   5744 C CG1 . VAL B 2 79  ? 31.508  -24.183 47.584  1.00 140.87 ?  375 VAL B CG1 1 
ATOM   5745 C CG2 . VAL B 2 79  ? 31.803  -21.826 46.729  1.00 134.07 ?  375 VAL B CG2 1 
ATOM   5746 N N   . ILE B 2 80  ? 27.587  -23.776 48.461  1.00 150.97 ?  376 ILE B N   1 
ATOM   5747 C CA  . ILE B 2 80  ? 26.770  -24.470 49.462  1.00 150.59 ?  376 ILE B CA  1 
ATOM   5748 C C   . ILE B 2 80  ? 27.307  -25.895 49.563  1.00 150.60 ?  376 ILE B C   1 
ATOM   5749 O O   . ILE B 2 80  ? 26.940  -26.761 48.765  1.00 150.98 ?  376 ILE B O   1 
ATOM   5750 C CB  . ILE B 2 80  ? 25.282  -24.457 49.096  1.00 149.84 ?  376 ILE B CB  1 
ATOM   5751 C CG1 . ILE B 2 80  ? 24.800  -23.035 48.798  1.00 149.01 ?  376 ILE B CG1 1 
ATOM   5752 C CG2 . ILE B 2 80  ? 24.447  -25.090 50.201  1.00 146.36 ?  376 ILE B CG2 1 
ATOM   5753 C CD1 . ILE B 2 80  ? 23.442  -22.981 48.123  1.00 145.18 ?  376 ILE B CD1 1 
ATOM   5754 N N   . GLN B 2 81  ? 28.174  -26.153 50.538  1.00 146.72 ?  377 GLN B N   1 
ATOM   5755 C CA  . GLN B 2 81  ? 28.936  -27.396 50.551  1.00 145.24 ?  377 GLN B CA  1 
ATOM   5756 C C   . GLN B 2 81  ? 28.822  -28.066 51.911  1.00 143.31 ?  377 GLN B C   1 
ATOM   5757 O O   . GLN B 2 81  ? 29.249  -27.501 52.925  1.00 138.56 ?  377 GLN B O   1 
ATOM   5758 C CB  . GLN B 2 81  ? 30.394  -27.124 50.177  1.00 143.95 ?  377 GLN B CB  1 
ATOM   5759 C CG  . GLN B 2 81  ? 31.318  -28.324 50.187  1.00 139.27 ?  377 GLN B CG  1 
ATOM   5760 C CD  . GLN B 2 81  ? 32.762  -27.885 50.063  1.00 136.00 ?  377 GLN B CD  1 
ATOM   5761 O OE1 . GLN B 2 81  ? 33.233  -27.084 50.864  1.00 131.92 ?  377 GLN B OE1 1 
ATOM   5762 N NE2 . GLN B 2 81  ? 33.475  -28.415 49.073  1.00 129.52 ?  377 GLN B NE2 1 
ATOM   5763 N N   . LYS B 2 82  ? 28.237  -29.267 51.919  1.00 144.46 ?  378 LYS B N   1 
ATOM   5764 C CA  . LYS B 2 82  ? 28.088  -30.033 53.149  1.00 140.10 ?  378 LYS B CA  1 
ATOM   5765 C C   . LYS B 2 82  ? 29.458  -30.308 53.761  1.00 134.15 ?  378 LYS B C   1 
ATOM   5766 O O   . LYS B 2 82  ? 30.433  -30.588 53.055  1.00 133.33 ?  378 LYS B O   1 
ATOM   5767 C CB  . LYS B 2 82  ? 27.331  -31.344 52.874  1.00 138.63 ?  378 LYS B CB  1 
ATOM   5768 C CG  . LYS B 2 82  ? 25.807  -31.187 52.662  1.00 133.78 ?  378 LYS B CG  1 
ATOM   5769 C CD  . LYS B 2 82  ? 25.076  -32.545 52.737  1.00 140.07 ?  378 LYS B CD  1 
ATOM   5770 C CE  . LYS B 2 82  ? 23.546  -32.400 52.693  1.00 137.35 ?  378 LYS B CE  1 
ATOM   5771 N NZ  . LYS B 2 82  ? 22.822  -33.715 52.651  1.00 126.92 ?  378 LYS B NZ  1 
ATOM   5772 N N   . CYS B 2 83  ? 29.527  -30.203 55.083  1.00 129.52 ?  379 CYS B N   1 
ATOM   5773 C CA  . CYS B 2 83  ? 30.781  -30.259 55.824  1.00 128.46 ?  379 CYS B CA  1 
ATOM   5774 C C   . CYS B 2 83  ? 31.172  -31.709 56.098  1.00 126.23 ?  379 CYS B C   1 
ATOM   5775 O O   . CYS B 2 83  ? 30.444  -32.433 56.782  1.00 127.73 ?  379 CYS B O   1 
ATOM   5776 C CB  . CYS B 2 83  ? 30.634  -29.478 57.129  1.00 130.13 ?  379 CYS B CB  1 
ATOM   5777 S SG  . CYS B 2 83  ? 32.093  -29.438 58.194  1.00 135.25 ?  379 CYS B SG  1 
ATOM   5778 N N   . ASN B 2 84  ? 32.325  -32.126 55.573  1.00 128.80 ?  380 ASN B N   1 
ATOM   5779 C CA  . ASN B 2 84  ? 32.825  -33.484 55.738  1.00 127.84 ?  380 ASN B CA  1 
ATOM   5780 C C   . ASN B 2 84  ? 33.748  -33.559 56.958  1.00 126.06 ?  380 ASN B C   1 
ATOM   5781 O O   . ASN B 2 84  ? 33.944  -32.586 57.694  1.00 123.94 ?  380 ASN B O   1 
ATOM   5782 C CB  . ASN B 2 84  ? 33.535  -33.954 54.461  1.00 122.09 ?  380 ASN B CB  1 
ATOM   5783 C CG  . ASN B 2 84  ? 33.322  -35.439 54.173  1.00 122.64 ?  380 ASN B CG  1 
ATOM   5784 O OD1 . ASN B 2 84  ? 33.569  -36.291 55.030  1.00 125.42 ?  380 ASN B OD1 1 
ATOM   5785 N ND2 . ASN B 2 84  ? 32.857  -35.752 52.964  1.00 115.02 ?  380 ASN B ND2 1 
ATOM   5786 N N   . ALA B 2 85  ? 34.320  -34.720 57.170  1.00 121.88 ?  381 ALA B N   1 
ATOM   5787 C CA  . ALA B 2 85  ? 35.088  -34.946 58.383  1.00 119.42 ?  381 ALA B CA  1 
ATOM   5788 C C   . ALA B 2 85  ? 36.467  -35.522 58.118  1.00 123.88 ?  381 ALA B C   1 
ATOM   5789 O O   . ALA B 2 85  ? 37.404  -35.205 58.856  1.00 118.86 ?  381 ALA B O   1 
ATOM   5790 C CB  . ALA B 2 85  ? 34.302  -35.876 59.306  1.00 122.78 ?  381 ALA B CB  1 
ATOM   5791 N N   . ARG B 2 86  ? 36.612  -36.367 57.095  1.00 125.74 ?  382 ARG B N   1 
ATOM   5792 C CA  . ARG B 2 86  ? 37.912  -36.916 56.730  1.00 125.08 ?  382 ARG B CA  1 
ATOM   5793 C C   . ARG B 2 86  ? 38.761  -35.858 56.011  1.00 123.38 ?  382 ARG B C   1 
ATOM   5794 O O   . ARG B 2 86  ? 38.260  -34.833 55.532  1.00 120.49 ?  382 ARG B O   1 
ATOM   5795 C CB  . ARG B 2 86  ? 37.733  -38.177 55.867  1.00 125.90 ?  382 ARG B CB  1 
ATOM   5796 C CG  . ARG B 2 86  ? 37.296  -39.421 56.672  1.00 137.74 ?  382 ARG B CG  1 
ATOM   5797 C CD  . ARG B 2 86  ? 36.724  -40.558 55.807  1.00 143.86 ?  382 ARG B CD  1 
ATOM   5798 N NE  . ARG B 2 86  ? 36.579  -41.809 56.561  1.00 146.02 ?  382 ARG B NE  1 
ATOM   5799 C CZ  . ARG B 2 86  ? 37.150  -42.970 56.234  1.00 151.85 ?  382 ARG B CZ  1 
ATOM   5800 N NH1 . ARG B 2 86  ? 37.901  -43.069 55.141  1.00 148.56 ?  382 ARG B NH1 1 
ATOM   5801 N NH2 . ARG B 2 86  ? 36.955  -44.046 56.992  1.00 151.96 ?  382 ARG B NH2 1 
ATOM   5802 N N   . TRP B 2 87  ? 40.070  -36.114 55.950  1.00 119.20 ?  383 TRP B N   1 
ATOM   5803 C CA  . TRP B 2 87  ? 41.061  -35.195 55.375  1.00 111.37 ?  383 TRP B CA  1 
ATOM   5804 C C   . TRP B 2 87  ? 41.686  -35.786 54.113  1.00 112.08 ?  383 TRP B C   1 
ATOM   5805 O O   . TRP B 2 87  ? 42.695  -36.489 54.204  1.00 113.95 ?  383 TRP B O   1 
ATOM   5806 C CB  . TRP B 2 87  ? 42.175  -34.929 56.362  1.00 111.06 ?  383 TRP B CB  1 
ATOM   5807 C CG  . TRP B 2 87  ? 41.847  -34.047 57.465  1.00 116.90 ?  383 TRP B CG  1 
ATOM   5808 C CD1 . TRP B 2 87  ? 41.433  -34.413 58.702  1.00 118.89 ?  383 TRP B CD1 1 
ATOM   5809 C CD2 . TRP B 2 87  ? 41.938  -32.620 57.470  1.00 113.96 ?  383 TRP B CD2 1 
ATOM   5810 N NE1 . TRP B 2 87  ? 41.240  -33.297 59.480  1.00 119.81 ?  383 TRP B NE1 1 
ATOM   5811 C CE2 . TRP B 2 87  ? 41.546  -32.184 58.742  1.00 111.71 ?  383 TRP B CE2 1 
ATOM   5812 C CE3 . TRP B 2 87  ? 42.299  -31.670 56.514  1.00 106.90 ?  383 TRP B CE3 1 
ATOM   5813 C CZ2 . TRP B 2 87  ? 41.507  -30.844 59.087  1.00 112.40 ?  383 TRP B CZ2 1 
ATOM   5814 C CZ3 . TRP B 2 87  ? 42.267  -30.340 56.859  1.00 107.32 ?  383 TRP B CZ3 1 
ATOM   5815 C CH2 . TRP B 2 87  ? 41.878  -29.936 58.137  1.00 111.57 ?  383 TRP B CH2 1 
ATOM   5816 N N   . THR B 2 88  ? 41.136  -35.476 52.933  1.00 106.16 ?  384 THR B N   1 
ATOM   5817 C CA  . THR B 2 88  ? 41.869  -35.848 51.728  1.00 100.89 ?  384 THR B CA  1 
ATOM   5818 C C   . THR B 2 88  ? 43.226  -35.162 51.751  1.00 97.87  ?  384 THR B C   1 
ATOM   5819 O O   . THR B 2 88  ? 43.401  -34.105 52.362  1.00 98.98  ?  384 THR B O   1 
ATOM   5820 C CB  . THR B 2 88  ? 41.120  -35.485 50.435  1.00 102.19 ?  384 THR B CB  1 
ATOM   5821 O OG1 . THR B 2 88  ? 40.779  -34.099 50.427  1.00 104.80 ?  384 THR B OG1 1 
ATOM   5822 C CG2 . THR B 2 88  ? 39.870  -36.304 50.282  1.00 106.48 ?  384 THR B CG2 1 
ATOM   5823 N N   . THR B 2 89  ? 44.208  -35.793 51.114  1.00 98.78  ?  385 THR B N   1 
ATOM   5824 C CA  . THR B 2 89  ? 45.530  -35.188 51.081  1.00 95.13  ?  385 THR B CA  1 
ATOM   5825 C C   . THR B 2 89  ? 45.465  -33.815 50.412  1.00 94.95  ?  385 THR B C   1 
ATOM   5826 O O   . THR B 2 89  ? 46.240  -32.910 50.748  1.00 86.38  ?  385 THR B O   1 
ATOM   5827 C CB  . THR B 2 89  ? 46.493  -36.112 50.335  1.00 88.85  ?  385 THR B CB  1 
ATOM   5828 O OG1 . THR B 2 89  ? 46.407  -37.436 50.889  1.00 93.51  ?  385 THR B OG1 1 
ATOM   5829 C CG2 . THR B 2 89  ? 47.912  -35.630 50.533  1.00 82.93  ?  385 THR B CG2 1 
ATOM   5830 N N   . GLU B 2 90  ? 44.525  -33.648 49.475  1.00 95.97  ?  386 GLU B N   1 
ATOM   5831 C CA  . GLU B 2 90  ? 44.230  -32.345 48.892  1.00 91.82  ?  386 GLU B CA  1 
ATOM   5832 C C   . GLU B 2 90  ? 43.856  -31.333 49.968  1.00 96.80  ?  386 GLU B C   1 
ATOM   5833 O O   . GLU B 2 90  ? 44.450  -30.249 50.064  1.00 92.84  ?  386 GLU B O   1 
ATOM   5834 C CB  . GLU B 2 90  ? 43.090  -32.492 47.879  1.00 101.05 ?  386 GLU B CB  1 
ATOM   5835 C CG  . GLU B 2 90  ? 42.641  -31.177 47.256  1.00 112.74 ?  386 GLU B CG  1 
ATOM   5836 C CD  . GLU B 2 90  ? 41.433  -31.317 46.333  1.00 125.66 ?  386 GLU B CD  1 
ATOM   5837 O OE1 . GLU B 2 90  ? 40.914  -32.453 46.188  1.00 126.05 ?  386 GLU B OE1 1 
ATOM   5838 O OE2 . GLU B 2 90  ? 41.017  -30.278 45.750  1.00 123.27 ?  386 GLU B OE2 1 
ATOM   5839 N N   . GLU B 2 91  ? 42.843  -31.666 50.775  1.00 98.58  ?  387 GLU B N   1 
ATOM   5840 C CA  . GLU B 2 91  ? 42.397  -30.770 51.833  1.00 92.01  ?  387 GLU B CA  1 
ATOM   5841 C C   . GLU B 2 91  ? 43.514  -30.486 52.824  1.00 87.16  ?  387 GLU B C   1 
ATOM   5842 O O   . GLU B 2 91  ? 43.574  -29.395 53.399  1.00 85.27  ?  387 GLU B O   1 
ATOM   5843 C CB  . GLU B 2 91  ? 41.178  -31.373 52.534  1.00 96.80  ?  387 GLU B CB  1 
ATOM   5844 C CG  . GLU B 2 91  ? 39.897  -31.337 51.695  1.00 103.93 ?  387 GLU B CG  1 
ATOM   5845 C CD  . GLU B 2 91  ? 38.920  -32.465 52.037  1.00 108.32 ?  387 GLU B CD  1 
ATOM   5846 O OE1 . GLU B 2 91  ? 39.206  -33.249 52.966  1.00 107.86 ?  387 GLU B OE1 1 
ATOM   5847 O OE2 . GLU B 2 91  ? 37.871  -32.575 51.363  1.00 111.04 ?  387 GLU B OE2 1 
ATOM   5848 N N   . GLN B 2 92  ? 44.419  -31.438 53.025  1.00 87.16  ?  388 GLN B N   1 
ATOM   5849 C CA  . GLN B 2 92  ? 45.515  -31.193 53.954  1.00 89.03  ?  388 GLN B CA  1 
ATOM   5850 C C   . GLN B 2 92  ? 46.430  -30.100 53.425  1.00 87.48  ?  388 GLN B C   1 
ATOM   5851 O O   . GLN B 2 92  ? 46.797  -29.180 54.166  1.00 88.59  ?  388 GLN B O   1 
ATOM   5852 C CB  . GLN B 2 92  ? 46.302  -32.481 54.205  1.00 93.51  ?  388 GLN B CB  1 
ATOM   5853 C CG  . GLN B 2 92  ? 45.519  -33.596 54.908  1.00 97.88  ?  388 GLN B CG  1 
ATOM   5854 C CD  . GLN B 2 92  ? 46.388  -34.796 55.275  1.00 99.58  ?  388 GLN B CD  1 
ATOM   5855 O OE1 . GLN B 2 92  ? 47.596  -34.677 55.451  1.00 94.09  ?  388 GLN B OE1 1 
ATOM   5856 N NE2 . GLN B 2 92  ? 45.770  -35.967 55.359  1.00 105.66 ?  388 GLN B NE2 1 
ATOM   5857 N N   . LEU B 2 93  ? 46.778  -30.163 52.131  1.00 92.44  ?  389 LEU B N   1 
ATOM   5858 C CA  . LEU B 2 93  ? 47.759  -29.233 51.569  1.00 82.51  ?  389 LEU B CA  1 
ATOM   5859 C C   . LEU B 2 93  ? 47.182  -27.841 51.395  1.00 83.98  ?  389 LEU B C   1 
ATOM   5860 O O   . LEU B 2 93  ? 47.910  -26.851 51.535  1.00 85.58  ?  389 LEU B O   1 
ATOM   5861 C CB  . LEU B 2 93  ? 48.284  -29.743 50.232  1.00 79.44  ?  389 LEU B CB  1 
ATOM   5862 C CG  . LEU B 2 93  ? 49.295  -30.878 50.299  1.00 78.15  ?  389 LEU B CG  1 
ATOM   5863 C CD1 . LEU B 2 93  ? 49.113  -31.681 49.056  1.00 77.44  ?  389 LEU B CD1 1 
ATOM   5864 C CD2 . LEU B 2 93  ? 50.731  -30.390 50.439  1.00 70.88  ?  389 LEU B CD2 1 
ATOM   5865 N N   . LEU B 2 94  ? 45.892  -27.742 51.067  1.00 84.04  ?  390 LEU B N   1 
ATOM   5866 C CA  . LEU B 2 94  ? 45.228  -26.449 51.145  1.00 82.04  ?  390 LEU B CA  1 
ATOM   5867 C C   . LEU B 2 94  ? 45.416  -25.828 52.528  1.00 88.17  ?  390 LEU B C   1 
ATOM   5868 O O   . LEU B 2 94  ? 45.766  -24.646 52.648  1.00 86.05  ?  390 LEU B O   1 
ATOM   5869 C CB  . LEU B 2 94  ? 43.748  -26.613 50.813  1.00 76.70  ?  390 LEU B CB  1 
ATOM   5870 C CG  . LEU B 2 94  ? 43.489  -26.879 49.339  1.00 85.46  ?  390 LEU B CG  1 
ATOM   5871 C CD1 . LEU B 2 94  ? 42.016  -27.168 49.061  1.00 95.92  ?  390 LEU B CD1 1 
ATOM   5872 C CD2 . LEU B 2 94  ? 43.959  -25.688 48.537  1.00 82.64  ?  390 LEU B CD2 1 
ATOM   5873 N N   . ALA B 2 95  ? 45.243  -26.631 53.585  1.00 89.51  ?  391 ALA B N   1 
ATOM   5874 C CA  . ALA B 2 95  ? 45.287  -26.112 54.949  1.00 85.89  ?  391 ALA B CA  1 
ATOM   5875 C C   . ALA B 2 95  ? 46.636  -25.477 55.262  1.00 88.44  ?  391 ALA B C   1 
ATOM   5876 O O   . ALA B 2 95  ? 46.713  -24.302 55.648  1.00 86.79  ?  391 ALA B O   1 
ATOM   5877 C CB  . ALA B 2 95  ? 44.975  -27.232 55.935  1.00 87.81  ?  391 ALA B CB  1 
ATOM   5878 N N   . VAL B 2 96  ? 47.718  -26.245 55.094  1.00 84.61  ?  392 VAL B N   1 
ATOM   5879 C CA  . VAL B 2 96  ? 49.060  -25.732 55.363  1.00 84.03  ?  392 VAL B CA  1 
ATOM   5880 C C   . VAL B 2 96  ? 49.321  -24.421 54.626  1.00 90.52  ?  392 VAL B C   1 
ATOM   5881 O O   . VAL B 2 96  ? 50.087  -23.569 55.094  1.00 91.68  ?  392 VAL B O   1 
ATOM   5882 C CB  . VAL B 2 96  ? 50.099  -26.804 54.993  1.00 85.09  ?  392 VAL B CB  1 
ATOM   5883 C CG1 . VAL B 2 96  ? 51.491  -26.192 54.839  1.00 90.77  ?  392 VAL B CG1 1 
ATOM   5884 C CG2 . VAL B 2 96  ? 50.100  -27.897 56.025  1.00 90.39  ?  392 VAL B CG2 1 
ATOM   5885 N N   . GLN B 2 97  ? 48.689  -24.221 53.475  1.00 87.63  ?  393 GLN B N   1 
ATOM   5886 C CA  . GLN B 2 97  ? 48.927  -22.969 52.777  1.00 87.87  ?  393 GLN B CA  1 
ATOM   5887 C C   . GLN B 2 97  ? 48.111  -21.832 53.358  1.00 89.52  ?  393 GLN B C   1 
ATOM   5888 O O   . GLN B 2 97  ? 48.580  -20.688 53.367  1.00 93.40  ?  393 GLN B O   1 
ATOM   5889 C CB  . GLN B 2 97  ? 48.634  -23.133 51.292  1.00 87.44  ?  393 GLN B CB  1 
ATOM   5890 C CG  . GLN B 2 97  ? 49.686  -23.952 50.589  1.00 83.92  ?  393 GLN B CG  1 
ATOM   5891 C CD  . GLN B 2 97  ? 49.365  -24.127 49.143  1.00 83.06  ?  393 GLN B CD  1 
ATOM   5892 O OE1 . GLN B 2 97  ? 49.788  -23.328 48.312  1.00 85.77  ?  393 GLN B OE1 1 
ATOM   5893 N NE2 . GLN B 2 97  ? 48.589  -25.161 48.822  1.00 78.56  ?  393 GLN B NE2 1 
ATOM   5894 N N   . ALA B 2 98  ? 46.898  -22.121 53.833  1.00 87.99  ?  394 ALA B N   1 
ATOM   5895 C CA  . ALA B 2 98  ? 46.088  -21.090 54.471  1.00 89.74  ?  394 ALA B CA  1 
ATOM   5896 C C   . ALA B 2 98  ? 46.712  -20.645 55.790  1.00 92.33  ?  394 ALA B C   1 
ATOM   5897 O O   . ALA B 2 98  ? 46.708  -19.454 56.125  1.00 87.72  ?  394 ALA B O   1 
ATOM   5898 C CB  . ALA B 2 98  ? 44.668  -21.611 54.679  1.00 86.89  ?  394 ALA B CB  1 
ATOM   5899 N N   . ILE B 2 99  ? 47.266  -21.591 56.546  1.00 91.78  ?  395 ILE B N   1 
ATOM   5900 C CA  . ILE B 2 99  ? 48.014  -21.232 57.742  1.00 92.39  ?  395 ILE B CA  1 
ATOM   5901 C C   . ILE B 2 99  ? 49.161  -20.305 57.376  1.00 91.88  ?  395 ILE B C   1 
ATOM   5902 O O   . ILE B 2 99  ? 49.479  -19.370 58.113  1.00 102.84 ?  395 ILE B O   1 
ATOM   5903 C CB  . ILE B 2 99  ? 48.513  -22.500 58.461  1.00 95.49  ?  395 ILE B CB  1 
ATOM   5904 C CG1 . ILE B 2 99  ? 47.336  -23.337 58.959  1.00 96.37  ?  395 ILE B CG1 1 
ATOM   5905 C CG2 . ILE B 2 99  ? 49.405  -22.150 59.636  1.00 98.16  ?  395 ILE B CG2 1 
ATOM   5906 C CD1 . ILE B 2 99  ? 47.759  -24.687 59.520  1.00 91.90  ?  395 ILE B CD1 1 
ATOM   5907 N N   . ARG B 2 100 ? 49.790  -20.534 56.228  1.00 93.67  ?  396 ARG B N   1 
ATOM   5908 C CA  . ARG B 2 100 ? 50.882  -19.668 55.795  1.00 97.44  ?  396 ARG B CA  1 
ATOM   5909 C C   . ARG B 2 100 ? 50.387  -18.285 55.380  1.00 94.87  ?  396 ARG B C   1 
ATOM   5910 O O   . ARG B 2 100 ? 51.163  -17.324 55.379  1.00 91.28  ?  396 ARG B O   1 
ATOM   5911 C CB  . ARG B 2 100 ? 51.636  -20.341 54.642  1.00 93.52  ?  396 ARG B CB  1 
ATOM   5912 C CG  . ARG B 2 100 ? 52.790  -19.534 54.066  1.00 92.97  ?  396 ARG B CG  1 
ATOM   5913 C CD  . ARG B 2 100 ? 53.802  -19.189 55.132  1.00 95.89  ?  396 ARG B CD  1 
ATOM   5914 N NE  . ARG B 2 100 ? 54.874  -18.316 54.651  1.00 95.19  ?  396 ARG B NE  1 
ATOM   5915 C CZ  . ARG B 2 100 ? 54.773  -16.998 54.515  1.00 94.61  ?  396 ARG B CZ  1 
ATOM   5916 N NH1 . ARG B 2 100 ? 53.635  -16.387 54.805  1.00 95.76  ?  396 ARG B NH1 1 
ATOM   5917 N NH2 . ARG B 2 100 ? 55.809  -16.292 54.083  1.00 91.42  ?  396 ARG B NH2 1 
ATOM   5918 N N   . LYS B 2 101 ? 49.112  -18.166 55.037  1.00 94.03  ?  397 LYS B N   1 
ATOM   5919 C CA  . LYS B 2 101 ? 48.550  -16.932 54.514  1.00 93.17  ?  397 LYS B CA  1 
ATOM   5920 C C   . LYS B 2 101 ? 47.665  -16.211 55.508  1.00 101.93 ?  397 LYS B C   1 
ATOM   5921 O O   . LYS B 2 101 ? 47.542  -14.984 55.433  1.00 102.40 ?  397 LYS B O   1 
ATOM   5922 C CB  . LYS B 2 101 ? 47.732  -17.226 53.259  1.00 90.77  ?  397 LYS B CB  1 
ATOM   5923 C CG  . LYS B 2 101 ? 47.096  -16.025 52.642  1.00 90.90  ?  397 LYS B CG  1 
ATOM   5924 C CD  . LYS B 2 101 ? 46.483  -16.384 51.323  1.00 94.30  ?  397 LYS B CD  1 
ATOM   5925 C CE  . LYS B 2 101 ? 45.923  -15.168 50.582  1.00 93.31  ?  397 LYS B CE  1 
ATOM   5926 N NZ  . LYS B 2 101 ? 44.644  -14.658 51.142  1.00 99.41  ?  397 LYS B NZ  1 
ATOM   5927 N N   . TYR B 2 102 ? 47.110  -16.960 56.448  1.00 101.88 ?  398 TYR B N   1 
ATOM   5928 C CA  . TYR B 2 102 ? 46.151  -16.315 57.363  1.00 102.18 ?  398 TYR B CA  1 
ATOM   5929 C C   . TYR B 2 102 ? 46.540  -16.495 58.820  1.00 105.83 ?  398 TYR B C   1 
ATOM   5930 O O   . TYR B 2 102 ? 45.720  -16.169 59.660  1.00 109.85 ?  398 TYR B O   1 
ATOM   5931 C CB  . TYR B 2 102 ? 44.798  -16.968 57.149  1.00 96.65  ?  398 TYR B CB  1 
ATOM   5932 C CG  . TYR B 2 102 ? 44.180  -16.664 55.817  1.00 96.18  ?  398 TYR B CG  1 
ATOM   5933 C CD1 . TYR B 2 102 ? 43.612  -15.440 55.572  1.00 92.71  ?  398 TYR B CD1 1 
ATOM   5934 C CD2 . TYR B 2 102 ? 44.136  -17.607 54.818  1.00 101.44 ?  398 TYR B CD2 1 
ATOM   5935 C CE1 . TYR B 2 102 ? 43.005  -15.153 54.369  1.00 93.20  ?  398 TYR B CE1 1 
ATOM   5936 C CE2 . TYR B 2 102 ? 43.540  -17.340 53.604  1.00 97.79  ?  398 TYR B CE2 1 
ATOM   5937 C CZ  . TYR B 2 102 ? 42.931  -16.126 53.404  1.00 99.15  ?  398 TYR B CZ  1 
ATOM   5938 O OH  . TYR B 2 102 ? 42.381  -15.807 52.205  1.00 97.84  ?  398 TYR B OH  1 
ATOM   5939 N N   . GLY B 2 103 ? 47.730  -17.001 59.097  1.00 104.59 ?  399 GLY B N   1 
ATOM   5940 C CA  . GLY B 2 103 ? 48.126  -17.179 60.501  1.00 106.45 ?  399 GLY B CA  1 
ATOM   5941 C C   . GLY B 2 103 ? 47.125  -18.016 61.273  1.00 110.26 ?  399 GLY B C   1 
ATOM   5942 O O   . GLY B 2 103 ? 47.002  -19.187 60.967  1.00 109.33 ?  399 GLY B O   1 
ATOM   5943 N N   . ARG B 2 104 ? 46.407  -17.418 62.224  1.00 111.17 ?  400 ARG B N   1 
ATOM   5944 C CA  . ARG B 2 104 ? 45.450  -18.186 63.057  1.00 110.48 ?  400 ARG B CA  1 
ATOM   5945 C C   . ARG B 2 104 ? 44.016  -17.768 62.760  1.00 107.13 ?  400 ARG B C   1 
ATOM   5946 O O   . ARG B 2 104 ? 43.155  -18.065 63.564  1.00 108.55 ?  400 ARG B O   1 
ATOM   5947 C CB  . ARG B 2 104 ? 45.681  -17.925 64.545  1.00 110.70 ?  400 ARG B CB  1 
ATOM   5948 C CG  . ARG B 2 104 ? 46.926  -18.577 65.122  1.00 110.76 ?  400 ARG B CG  1 
ATOM   5949 C CD  . ARG B 2 104 ? 47.738  -17.589 65.935  1.00 112.95 ?  400 ARG B CD  1 
ATOM   5950 N NE  . ARG B 2 104 ? 49.023  -18.111 66.361  1.00 116.65 ?  400 ARG B NE  1 
ATOM   5951 C CZ  . ARG B 2 104 ? 50.145  -17.414 66.350  1.00 115.84 ?  400 ARG B CZ  1 
ATOM   5952 N NH1 . ARG B 2 104 ? 50.132  -16.162 65.939  1.00 107.25 ?  400 ARG B NH1 1 
ATOM   5953 N NH2 . ARG B 2 104 ? 51.274  -17.966 66.755  1.00 106.97 ?  400 ARG B NH2 1 
ATOM   5954 N N   . ASP B 2 105 ? 43.736  -17.146 61.626  1.00 101.28 ?  401 ASP B N   1 
ATOM   5955 C CA  . ASP B 2 105 ? 42.324  -16.778 61.370  1.00 100.81 ?  401 ASP B CA  1 
ATOM   5956 C C   . ASP B 2 105 ? 41.560  -18.027 60.961  1.00 97.74  ?  401 ASP B C   1 
ATOM   5957 O O   . ASP B 2 105 ? 41.232  -18.133 59.808  1.00 104.04 ?  401 ASP B O   1 
ATOM   5958 C CB  . ASP B 2 105 ? 42.235  -15.726 60.272  1.00 101.63 ?  401 ASP B CB  1 
ATOM   5959 C CG  . ASP B 2 105 ? 40.824  -15.295 59.944  1.00 104.99 ?  401 ASP B CG  1 
ATOM   5960 O OD1 . ASP B 2 105 ? 39.889  -16.024 60.295  1.00 101.96 ?  401 ASP B OD1 1 
ATOM   5961 O OD2 . ASP B 2 105 ? 40.680  -14.235 59.328  1.00 97.52  ?  401 ASP B OD2 1 
ATOM   5962 N N   . PHE B 2 106 ? 41.107  -18.835 61.907  1.00 100.21 ?  402 PHE B N   1 
ATOM   5963 C CA  . PHE B 2 106 ? 40.445  -20.124 61.593  1.00 104.46 ?  402 PHE B CA  1 
ATOM   5964 C C   . PHE B 2 106 ? 39.206  -19.974 60.708  1.00 105.78 ?  402 PHE B C   1 
ATOM   5965 O O   . PHE B 2 106 ? 38.898  -20.914 60.009  1.00 106.46 ?  402 PHE B O   1 
ATOM   5966 C CB  . PHE B 2 106 ? 40.146  -20.884 62.880  1.00 106.48 ?  402 PHE B CB  1 
ATOM   5967 C CG  . PHE B 2 106 ? 41.268  -20.875 63.883  1.00 111.55 ?  402 PHE B CG  1 
ATOM   5968 C CD1 . PHE B 2 106 ? 41.042  -20.540 65.200  1.00 111.60 ?  402 PHE B CD1 1 
ATOM   5969 C CD2 . PHE B 2 106 ? 42.549  -21.221 63.517  1.00 112.84 ?  402 PHE B CD2 1 
ATOM   5970 C CE1 . PHE B 2 106 ? 42.075  -20.538 66.120  1.00 111.08 ?  402 PHE B CE1 1 
ATOM   5971 C CE2 . PHE B 2 106 ? 43.580  -21.212 64.438  1.00 112.06 ?  402 PHE B CE2 1 
ATOM   5972 C CZ  . PHE B 2 106 ? 43.343  -20.873 65.738  1.00 107.83 ?  402 PHE B CZ  1 
ATOM   5973 N N   . GLN B 2 107 ? 38.472  -18.875 60.785  1.00 104.77 ?  403 GLN B N   1 
ATOM   5974 C CA  . GLN B 2 107 ? 37.284  -18.726 59.922  1.00 106.67 ?  403 GLN B CA  1 
ATOM   5975 C C   . GLN B 2 107 ? 37.743  -18.711 58.466  1.00 110.46 ?  403 GLN B C   1 
ATOM   5976 O O   . GLN B 2 107 ? 37.143  -19.409 57.647  1.00 108.28 ?  403 GLN B O   1 
ATOM   5977 C CB  . GLN B 2 107 ? 36.619  -17.396 60.234  1.00 98.96  ?  403 GLN B CB  1 
ATOM   5978 C CG  . GLN B 2 107 ? 35.393  -17.149 59.387  1.00 99.98  ?  403 GLN B CG  1 
ATOM   5979 C CD  . GLN B 2 107 ? 34.489  -18.336 59.538  1.00 113.45 ?  403 GLN B CD  1 
ATOM   5980 O OE1 . GLN B 2 107 ? 33.777  -18.720 58.625  1.00 122.67 ?  403 GLN B OE1 1 
ATOM   5981 N NE2 . GLN B 2 107 ? 34.528  -18.935 60.708  1.00 111.17 ?  403 GLN B NE2 1 
ATOM   5982 N N   . ALA B 2 108 ? 38.766  -17.923 58.158  1.00 107.56 ?  404 ALA B N   1 
ATOM   5983 C CA  . ALA B 2 108 ? 39.206  -17.867 56.774  1.00 103.35 ?  404 ALA B CA  1 
ATOM   5984 C C   . ALA B 2 108 ? 39.675  -19.237 56.318  1.00 105.74 ?  404 ALA B C   1 
ATOM   5985 O O   . ALA B 2 108 ? 39.316  -19.706 55.230  1.00 106.97 ?  404 ALA B O   1 
ATOM   5986 C CB  . ALA B 2 108 ? 40.316  -16.841 56.632  1.00 98.11  ?  404 ALA B CB  1 
ATOM   5987 N N   . ILE B 2 109 ? 40.450  -19.914 57.162  1.00 97.42  ?  405 ILE B N   1 
ATOM   5988 C CA  . ILE B 2 109 ? 41.018  -21.195 56.760  1.00 96.20  ?  405 ILE B CA  1 
ATOM   5989 C C   . ILE B 2 109 ? 39.914  -22.214 56.505  1.00 100.21 ?  405 ILE B C   1 
ATOM   5990 O O   . ILE B 2 109 ? 39.967  -22.984 55.541  1.00 103.59 ?  405 ILE B O   1 
ATOM   5991 C CB  . ILE B 2 109 ? 42.018  -21.687 57.815  1.00 90.82  ?  405 ILE B CB  1 
ATOM   5992 C CG1 . ILE B 2 109 ? 43.195  -20.716 57.891  1.00 89.83  ?  405 ILE B CG1 1 
ATOM   5993 C CG2 . ILE B 2 109 ? 42.430  -23.127 57.517  1.00 90.97  ?  405 ILE B CG2 1 
ATOM   5994 C CD1 . ILE B 2 109 ? 44.084  -20.956 59.074  1.00 97.41  ?  405 ILE B CD1 1 
ATOM   5995 N N   . SER B 2 110 ? 38.891  -22.228 57.358  1.00 105.07 ?  406 SER B N   1 
ATOM   5996 C CA  . SER B 2 110 ? 37.727  -23.070 57.115  1.00 106.82 ?  406 SER B CA  1 
ATOM   5997 C C   . SER B 2 110 ? 36.969  -22.668 55.858  1.00 107.54 ?  406 SER B C   1 
ATOM   5998 O O   . SER B 2 110 ? 36.218  -23.486 55.315  1.00 109.13 ?  406 SER B O   1 
ATOM   5999 C CB  . SER B 2 110 ? 36.779  -23.016 58.313  1.00 109.92 ?  406 SER B CB  1 
ATOM   6000 O OG  . SER B 2 110 ? 35.504  -23.535 57.971  1.00 114.60 ?  406 SER B OG  1 
ATOM   6001 N N   . ASP B 2 111 ? 37.126  -21.425 55.396  1.00 105.27 ?  407 ASP B N   1 
ATOM   6002 C CA  . ASP B 2 111 ? 36.413  -20.997 54.196  1.00 110.27 ?  407 ASP B CA  1 
ATOM   6003 C C   . ASP B 2 111 ? 37.140  -21.418 52.932  1.00 110.10 ?  407 ASP B C   1 
ATOM   6004 O O   . ASP B 2 111 ? 36.500  -21.740 51.923  1.00 110.04 ?  407 ASP B O   1 
ATOM   6005 C CB  . ASP B 2 111 ? 36.223  -19.480 54.187  1.00 115.80 ?  407 ASP B CB  1 
ATOM   6006 C CG  . ASP B 2 111 ? 35.245  -19.006 55.237  1.00 117.37 ?  407 ASP B CG  1 
ATOM   6007 O OD1 . ASP B 2 111 ? 34.463  -19.854 55.743  1.00 111.65 ?  407 ASP B OD1 1 
ATOM   6008 O OD2 . ASP B 2 111 ? 35.262  -17.783 55.535  1.00 116.29 ?  407 ASP B OD2 1 
ATOM   6009 N N   . VAL B 2 112 ? 38.474  -21.372 52.965  1.00 109.24 ?  408 VAL B N   1 
ATOM   6010 C CA  . VAL B 2 112 ? 39.275  -21.882 51.858  1.00 104.69 ?  408 VAL B CA  1 
ATOM   6011 C C   . VAL B 2 112 ? 38.986  -23.361 51.639  1.00 104.87 ?  408 VAL B C   1 
ATOM   6012 O O   . VAL B 2 112 ? 38.498  -23.767 50.576  1.00 106.27 ?  408 VAL B O   1 
ATOM   6013 C CB  . VAL B 2 112 ? 40.769  -21.638 52.121  1.00 100.09 ?  408 VAL B CB  1 
ATOM   6014 C CG1 . VAL B 2 112 ? 41.603  -22.426 51.140  1.00 97.43  ?  408 VAL B CG1 1 
ATOM   6015 C CG2 . VAL B 2 112 ? 41.077  -20.166 52.004  1.00 96.86  ?  408 VAL B CG2 1 
ATOM   6016 N N   . ILE B 2 113 ? 39.269  -24.187 52.651  1.00 99.88  ?  409 ILE B N   1 
ATOM   6017 C CA  . ILE B 2 113 ? 39.070  -25.625 52.508  1.00 98.32  ?  409 ILE B CA  1 
ATOM   6018 C C   . ILE B 2 113 ? 37.616  -25.940 52.224  1.00 105.42 ?  409 ILE B C   1 
ATOM   6019 O O   . ILE B 2 113 ? 37.298  -26.973 51.625  1.00 111.63 ?  409 ILE B O   1 
ATOM   6020 C CB  . ILE B 2 113 ? 39.567  -26.353 53.761  1.00 98.06  ?  409 ILE B CB  1 
ATOM   6021 C CG1 . ILE B 2 113 ? 40.926  -25.806 54.161  1.00 94.70  ?  409 ILE B CG1 1 
ATOM   6022 C CG2 . ILE B 2 113 ? 39.665  -27.840 53.501  1.00 100.09 ?  409 ILE B CG2 1 
ATOM   6023 C CD1 . ILE B 2 113 ? 41.500  -26.472 55.372  1.00 95.38  ?  409 ILE B CD1 1 
ATOM   6024 N N   . GLY B 2 114 ? 36.716  -25.064 52.631  1.00 109.11 ?  410 GLY B N   1 
ATOM   6025 C CA  . GLY B 2 114 ? 35.315  -25.246 52.295  1.00 111.89 ?  410 GLY B CA  1 
ATOM   6026 C C   . GLY B 2 114 ? 34.529  -26.282 53.053  1.00 117.90 ?  410 GLY B C   1 
ATOM   6027 O O   . GLY B 2 114 ? 33.434  -25.981 53.536  1.00 122.12 ?  410 GLY B O   1 
ATOM   6028 N N   . ASN B 2 115 ? 35.027  -27.522 53.130  1.00 114.99 ?  411 ASN B N   1 
ATOM   6029 C CA  . ASN B 2 115 ? 34.217  -28.590 53.701  1.00 118.23 ?  411 ASN B CA  1 
ATOM   6030 C C   . ASN B 2 115 ? 34.590  -28.877 55.145  1.00 119.79 ?  411 ASN B C   1 
ATOM   6031 O O   . ASN B 2 115 ? 34.090  -29.846 55.726  1.00 122.56 ?  411 ASN B O   1 
ATOM   6032 C CB  . ASN B 2 115 ? 34.306  -29.886 52.865  1.00 116.77 ?  411 ASN B CB  1 
ATOM   6033 C CG  . ASN B 2 115 ? 35.631  -30.633 53.010  1.00 115.84 ?  411 ASN B CG  1 
ATOM   6034 O OD1 . ASN B 2 115 ? 36.481  -30.333 53.852  1.00 114.25 ?  411 ASN B OD1 1 
ATOM   6035 N ND2 . ASN B 2 115 ? 35.790  -31.651 52.180  1.00 119.33 ?  411 ASN B ND2 1 
ATOM   6036 N N   . LYS B 2 116 ? 35.460  -28.074 55.736  1.00 113.43 ?  412 LYS B N   1 
ATOM   6037 C CA  . LYS B 2 116 ? 35.776  -28.235 57.138  1.00 115.19 ?  412 LYS B CA  1 
ATOM   6038 C C   . LYS B 2 116 ? 35.364  -27.030 57.955  1.00 117.30 ?  412 LYS B C   1 
ATOM   6039 O O   . LYS B 2 116 ? 35.521  -25.881 57.528  1.00 115.37 ?  412 LYS B O   1 
ATOM   6040 C CB  . LYS B 2 116 ? 37.241  -28.558 57.332  1.00 109.69 ?  412 LYS B CB  1 
ATOM   6041 C CG  . LYS B 2 116 ? 37.413  -29.935 56.891  1.00 112.83 ?  412 LYS B CG  1 
ATOM   6042 C CD  . LYS B 2 116 ? 38.763  -30.467 57.100  1.00 110.63 ?  412 LYS B CD  1 
ATOM   6043 C CE  . LYS B 2 116 ? 38.692  -31.941 56.774  1.00 113.08 ?  412 LYS B CE  1 
ATOM   6044 N NZ  . LYS B 2 116 ? 38.219  -32.122 55.344  1.00 114.59 ?  412 LYS B NZ  1 
ATOM   6045 N N   . SER B 2 117 ? 34.781  -27.335 59.111  1.00 120.61 ?  413 SER B N   1 
ATOM   6046 C CA  . SER B 2 117 ? 34.337  -26.358 60.081  1.00 121.31 ?  413 SER B CA  1 
ATOM   6047 C C   . SER B 2 117 ? 35.482  -25.973 61.007  1.00 117.41 ?  413 SER B C   1 
ATOM   6048 O O   . SER B 2 117 ? 36.523  -26.637 61.090  1.00 115.49 ?  413 SER B O   1 
ATOM   6049 C CB  . SER B 2 117 ? 33.182  -26.900 60.918  1.00 123.24 ?  413 SER B CB  1 
ATOM   6050 O OG  . SER B 2 117 ? 33.657  -27.827 61.878  1.00 119.62 ?  413 SER B OG  1 
ATOM   6051 N N   . VAL B 2 118 ? 35.231  -24.911 61.766  1.00 114.86 ?  414 VAL B N   1 
ATOM   6052 C CA  . VAL B 2 118 ? 36.304  -24.174 62.407  1.00 113.57 ?  414 VAL B CA  1 
ATOM   6053 C C   . VAL B 2 118 ? 36.945  -25.002 63.512  1.00 117.09 ?  414 VAL B C   1 
ATOM   6054 O O   . VAL B 2 118 ? 38.097  -24.760 63.903  1.00 113.47 ?  414 VAL B O   1 
ATOM   6055 C CB  . VAL B 2 118 ? 35.722  -22.858 62.940  1.00 108.70 ?  414 VAL B CB  1 
ATOM   6056 C CG1 . VAL B 2 118 ? 36.820  -21.975 63.505  1.00 106.64 ?  414 VAL B CG1 1 
ATOM   6057 C CG2 . VAL B 2 118 ? 34.839  -22.183 61.886  1.00 103.29 ?  414 VAL B CG2 1 
ATOM   6058 N N   . VAL B 2 119 ? 36.212  -25.990 64.030  1.00 119.03 ?  415 VAL B N   1 
ATOM   6059 C CA  . VAL B 2 119 ? 36.725  -26.809 65.120  1.00 121.09 ?  415 VAL B CA  1 
ATOM   6060 C C   . VAL B 2 119 ? 37.776  -27.783 64.603  1.00 121.90 ?  415 VAL B C   1 
ATOM   6061 O O   . VAL B 2 119 ? 38.898  -27.829 65.122  1.00 120.45 ?  415 VAL B O   1 
ATOM   6062 C CB  . VAL B 2 119 ? 35.569  -27.525 65.853  1.00 124.87 ?  415 VAL B CB  1 
ATOM   6063 C CG1 . VAL B 2 119 ? 34.655  -28.274 64.878  1.00 124.33 ?  415 VAL B CG1 1 
ATOM   6064 C CG2 . VAL B 2 119 ? 36.109  -28.478 66.929  1.00 123.60 ?  415 VAL B CG2 1 
ATOM   6065 N N   . GLN B 2 120 ? 37.453  -28.557 63.553  1.00 120.23 ?  416 GLN B N   1 
ATOM   6066 C CA  . GLN B 2 120 ? 38.458  -29.497 63.079  1.00 119.43 ?  416 GLN B CA  1 
ATOM   6067 C C   . GLN B 2 120 ? 39.648  -28.771 62.482  1.00 114.97 ?  416 GLN B C   1 
ATOM   6068 O O   . GLN B 2 120 ? 40.722  -29.367 62.375  1.00 115.92 ?  416 GLN B O   1 
ATOM   6069 C CB  . GLN B 2 120 ? 37.897  -30.517 62.074  1.00 114.68 ?  416 GLN B CB  1 
ATOM   6070 C CG  . GLN B 2 120 ? 37.181  -29.982 60.862  1.00 116.28 ?  416 GLN B CG  1 
ATOM   6071 C CD  . GLN B 2 120 ? 35.692  -29.992 61.033  1.00 117.56 ?  416 GLN B CD  1 
ATOM   6072 O OE1 . GLN B 2 120 ? 35.166  -29.331 61.921  1.00 123.36 ?  416 GLN B OE1 1 
ATOM   6073 N NE2 . GLN B 2 120 ? 35.000  -30.778 60.211  1.00 112.69 ?  416 GLN B NE2 1 
ATOM   6074 N N   . VAL B 2 121 ? 39.497  -27.493 62.130  1.00 112.35 ?  417 VAL B N   1 
ATOM   6075 C CA  . VAL B 2 121 ? 40.673  -26.684 61.828  1.00 113.50 ?  417 VAL B CA  1 
ATOM   6076 C C   . VAL B 2 121 ? 41.571  -26.605 63.057  1.00 118.72 ?  417 VAL B C   1 
ATOM   6077 O O   . VAL B 2 121 ? 42.781  -26.850 62.980  1.00 115.04 ?  417 VAL B O   1 
ATOM   6078 C CB  . VAL B 2 121 ? 40.264  -25.282 61.348  1.00 111.04 ?  417 VAL B CB  1 
ATOM   6079 C CG1 . VAL B 2 121 ? 41.513  -24.448 61.038  1.00 104.23 ?  417 VAL B CG1 1 
ATOM   6080 C CG2 . VAL B 2 121 ? 39.303  -25.370 60.171  1.00 111.40 ?  417 VAL B CG2 1 
ATOM   6081 N N   . LYS B 2 122 ? 40.982  -26.263 64.211  1.00 122.67 ?  418 LYS B N   1 
ATOM   6082 C CA  . LYS B 2 122 ? 41.700  -26.320 65.483  1.00 117.74 ?  418 LYS B CA  1 
ATOM   6083 C C   . LYS B 2 122 ? 42.262  -27.718 65.726  1.00 117.14 ?  418 LYS B C   1 
ATOM   6084 O O   . LYS B 2 122 ? 43.462  -27.885 65.978  1.00 115.87 ?  418 LYS B O   1 
ATOM   6085 C CB  . LYS B 2 122 ? 40.770  -25.911 66.627  1.00 122.65 ?  418 LYS B CB  1 
ATOM   6086 C CG  . LYS B 2 122 ? 40.489  -24.415 66.811  1.00 122.71 ?  418 LYS B CG  1 
ATOM   6087 C CD  . LYS B 2 122 ? 39.264  -24.227 67.746  1.00 132.20 ?  418 LYS B CD  1 
ATOM   6088 C CE  . LYS B 2 122 ? 39.501  -24.812 69.173  1.00 135.63 ?  418 LYS B CE  1 
ATOM   6089 N NZ  . LYS B 2 122 ? 38.326  -24.771 70.120  1.00 121.32 ?  418 LYS B NZ  1 
ATOM   6090 N N   . ASN B 2 123 ? 41.395  -28.738 65.666  1.00 120.32 ?  419 ASN B N   1 
ATOM   6091 C CA  . ASN B 2 123 ? 41.827  -30.136 65.748  1.00 126.68 ?  419 ASN B CA  1 
ATOM   6092 C C   . ASN B 2 123 ? 43.037  -30.399 64.859  1.00 124.47 ?  419 ASN B C   1 
ATOM   6093 O O   . ASN B 2 123 ? 44.008  -31.047 65.269  1.00 121.38 ?  419 ASN B O   1 
ATOM   6094 C CB  . ASN B 2 123 ? 40.680  -31.077 65.338  1.00 129.34 ?  419 ASN B CB  1 
ATOM   6095 C CG  . ASN B 2 123 ? 39.670  -31.318 66.454  1.00 132.26 ?  419 ASN B CG  1 
ATOM   6096 O OD1 . ASN B 2 123 ? 38.561  -30.776 66.427  1.00 130.34 ?  419 ASN B OD1 1 
ATOM   6097 N ND2 . ASN B 2 123 ? 40.025  -32.193 67.404  1.00 134.84 ?  419 ASN B ND2 1 
ATOM   6098 N N   . PHE B 2 124 ? 42.978  -29.897 63.625  1.00 121.79 ?  420 PHE B N   1 
ATOM   6099 C CA  . PHE B 2 124 ? 44.062  -30.108 62.676  1.00 121.55 ?  420 PHE B CA  1 
ATOM   6100 C C   . PHE B 2 124 ? 45.366  -29.534 63.206  1.00 119.33 ?  420 PHE B C   1 
ATOM   6101 O O   . PHE B 2 124 ? 46.411  -30.200 63.179  1.00 120.38 ?  420 PHE B O   1 
ATOM   6102 C CB  . PHE B 2 124 ? 43.697  -29.471 61.334  1.00 121.17 ?  420 PHE B CB  1 
ATOM   6103 C CG  . PHE B 2 124 ? 44.786  -29.564 60.296  1.00 118.33 ?  420 PHE B CG  1 
ATOM   6104 C CD1 . PHE B 2 124 ? 44.987  -30.738 59.582  1.00 116.44 ?  420 PHE B CD1 1 
ATOM   6105 C CD2 . PHE B 2 124 ? 45.619  -28.482 60.048  1.00 112.85 ?  420 PHE B CD2 1 
ATOM   6106 C CE1 . PHE B 2 124 ? 45.989  -30.822 58.639  1.00 111.97 ?  420 PHE B CE1 1 
ATOM   6107 C CE2 . PHE B 2 124 ? 46.624  -28.564 59.105  1.00 108.09 ?  420 PHE B CE2 1 
ATOM   6108 C CZ  . PHE B 2 124 ? 46.808  -29.734 58.398  1.00 106.58 ?  420 PHE B CZ  1 
ATOM   6109 N N   . PHE B 2 125 ? 45.317  -28.292 63.698  1.00 115.78 ?  421 PHE B N   1 
ATOM   6110 C CA  . PHE B 2 125 ? 46.499  -27.629 64.233  1.00 116.17 ?  421 PHE B CA  1 
ATOM   6111 C C   . PHE B 2 125 ? 47.258  -28.500 65.221  1.00 119.36 ?  421 PHE B C   1 
ATOM   6112 O O   . PHE B 2 125 ? 48.456  -28.277 65.428  1.00 117.40 ?  421 PHE B O   1 
ATOM   6113 C CB  . PHE B 2 125 ? 46.101  -26.326 64.924  1.00 112.62 ?  421 PHE B CB  1 
ATOM   6114 C CG  . PHE B 2 125 ? 46.035  -25.131 64.010  1.00 108.52 ?  421 PHE B CG  1 
ATOM   6115 C CD1 . PHE B 2 125 ? 44.899  -24.884 63.251  1.00 111.15 ?  421 PHE B CD1 1 
ATOM   6116 C CD2 . PHE B 2 125 ? 47.090  -24.226 63.945  1.00 101.11 ?  421 PHE B CD2 1 
ATOM   6117 C CE1 . PHE B 2 125 ? 44.818  -23.767 62.417  1.00 111.32 ?  421 PHE B CE1 1 
ATOM   6118 C CE2 . PHE B 2 125 ? 47.024  -23.100 63.120  1.00 102.97 ?  421 PHE B CE2 1 
ATOM   6119 C CZ  . PHE B 2 125 ? 45.885  -22.869 62.352  1.00 106.64 ?  421 PHE B CZ  1 
ATOM   6120 N N   . VAL B 2 126 ? 46.598  -29.492 65.825  1.00 119.07 ?  422 VAL B N   1 
ATOM   6121 C CA  . VAL B 2 126 ? 47.236  -30.316 66.844  1.00 120.97 ?  422 VAL B CA  1 
ATOM   6122 C C   . VAL B 2 126 ? 47.620  -31.690 66.306  1.00 122.79 ?  422 VAL B C   1 
ATOM   6123 O O   . VAL B 2 126 ? 48.791  -32.077 66.371  1.00 125.27 ?  422 VAL B O   1 
ATOM   6124 C CB  . VAL B 2 126 ? 46.335  -30.464 68.082  1.00 124.17 ?  422 VAL B CB  1 
ATOM   6125 C CG1 . VAL B 2 126 ? 47.133  -31.063 69.233  1.00 118.78 ?  422 VAL B CG1 1 
ATOM   6126 C CG2 . VAL B 2 126 ? 45.734  -29.121 68.469  1.00 119.63 ?  422 VAL B CG2 1 
ATOM   6127 N N   . ASN B 2 127 ? 46.640  -32.454 65.812  1.00 122.31 ?  423 ASN B N   1 
ATOM   6128 C CA  . ASN B 2 127 ? 46.918  -33.828 65.392  1.00 128.57 ?  423 ASN B CA  1 
ATOM   6129 C C   . ASN B 2 127 ? 48.077  -33.873 64.403  1.00 127.30 ?  423 ASN B C   1 
ATOM   6130 O O   . ASN B 2 127 ? 49.017  -34.672 64.541  1.00 125.69 ?  423 ASN B O   1 
ATOM   6131 C CB  . ASN B 2 127 ? 45.662  -34.460 64.779  1.00 126.65 ?  423 ASN B CB  1 
ATOM   6132 C CG  . ASN B 2 127 ? 44.470  -34.442 65.721  1.00 130.13 ?  423 ASN B CG  1 
ATOM   6133 O OD1 . ASN B 2 127 ? 43.425  -33.870 65.405  1.00 128.28 ?  423 ASN B OD1 1 
ATOM   6134 N ND2 . ASN B 2 127 ? 44.610  -35.099 66.873  1.00 135.78 ?  423 ASN B ND2 1 
ATOM   6135 N N   . TYR B 2 128 ? 48.035  -32.989 63.409  1.00 126.11 ?  424 TYR B N   1 
ATOM   6136 C CA  . TYR B 2 128 ? 49.048  -32.928 62.369  1.00 125.48 ?  424 TYR B CA  1 
ATOM   6137 C C   . TYR B 2 128 ? 50.096  -31.858 62.669  1.00 116.41 ?  424 TYR B C   1 
ATOM   6138 O O   . TYR B 2 128 ? 50.725  -31.333 61.757  1.00 110.20 ?  424 TYR B O   1 
ATOM   6139 C CB  . TYR B 2 128 ? 48.365  -32.711 61.012  1.00 114.56 ?  424 TYR B CB  1 
ATOM   6140 C CG  . TYR B 2 128 ? 47.751  -33.986 60.436  1.00 112.24 ?  424 TYR B CG  1 
ATOM   6141 C CD1 . TYR B 2 128 ? 48.522  -35.125 60.260  1.00 115.89 ?  424 TYR B CD1 1 
ATOM   6142 C CD2 . TYR B 2 128 ? 46.391  -34.068 60.121  1.00 111.78 ?  424 TYR B CD2 1 
ATOM   6143 C CE1 . TYR B 2 128 ? 47.971  -36.307 59.734  1.00 121.36 ?  424 TYR B CE1 1 
ATOM   6144 C CE2 . TYR B 2 128 ? 45.824  -35.259 59.605  1.00 114.82 ?  424 TYR B CE2 1 
ATOM   6145 C CZ  . TYR B 2 128 ? 46.628  -36.378 59.416  1.00 120.06 ?  424 TYR B CZ  1 
ATOM   6146 O OH  . TYR B 2 128 ? 46.125  -37.568 58.904  1.00 113.61 ?  424 TYR B OH  1 
ATOM   6147 N N   . ARG B 2 129 ? 50.329  -31.572 63.951  1.00 119.48 ?  425 ARG B N   1 
ATOM   6148 C CA  . ARG B 2 129 ? 51.190  -30.457 64.338  1.00 116.56 ?  425 ARG B CA  1 
ATOM   6149 C C   . ARG B 2 129 ? 52.659  -30.772 64.111  1.00 113.16 ?  425 ARG B C   1 
ATOM   6150 O O   . ARG B 2 129 ? 53.399  -29.951 63.559  1.00 104.05 ?  425 ARG B O   1 
ATOM   6151 C CB  . ARG B 2 129 ? 50.957  -30.098 65.796  1.00 119.62 ?  425 ARG B CB  1 
ATOM   6152 C CG  . ARG B 2 129 ? 51.852  -29.015 66.339  1.00 118.23 ?  425 ARG B CG  1 
ATOM   6153 C CD  . ARG B 2 129 ? 51.149  -28.344 67.502  1.00 123.24 ?  425 ARG B CD  1 
ATOM   6154 N NE  . ARG B 2 129 ? 52.011  -27.469 68.291  1.00 126.58 ?  425 ARG B NE  1 
ATOM   6155 C CZ  . ARG B 2 129 ? 52.987  -27.897 69.090  1.00 125.84 ?  425 ARG B CZ  1 
ATOM   6156 N NH1 . ARG B 2 129 ? 53.245  -29.196 69.200  1.00 123.87 ?  425 ARG B NH1 1 
ATOM   6157 N NH2 . ARG B 2 129 ? 53.712  -27.023 69.779  1.00 118.61 ?  425 ARG B NH2 1 
ATOM   6158 N N   . ARG B 2 130 ? 53.109  -31.934 64.588  1.00 119.49 ?  426 ARG B N   1 
ATOM   6159 C CA  . ARG B 2 130 ? 54.485  -32.360 64.361  1.00 120.19 ?  426 ARG B CA  1 
ATOM   6160 C C   . ARG B 2 130 ? 54.773  -32.483 62.871  1.00 119.50 ?  426 ARG B C   1 
ATOM   6161 O O   . ARG B 2 130 ? 55.760  -31.939 62.357  1.00 111.17 ?  426 ARG B O   1 
ATOM   6162 C CB  . ARG B 2 130 ? 54.718  -33.715 65.029  1.00 129.14 ?  426 ARG B CB  1 
ATOM   6163 C CG  . ARG B 2 130 ? 54.244  -33.838 66.455  1.00 137.49 ?  426 ARG B CG  1 
ATOM   6164 C CD  . ARG B 2 130 ? 54.545  -35.239 66.975  1.00 143.81 ?  426 ARG B CD  1 
ATOM   6165 N NE  . ARG B 2 130 ? 54.990  -35.206 68.361  1.00 145.96 ?  426 ARG B NE  1 
ATOM   6166 C CZ  . ARG B 2 130 ? 55.884  -36.044 68.870  1.00 151.88 ?  426 ARG B CZ  1 
ATOM   6167 N NH1 . ARG B 2 130 ? 56.424  -36.977 68.093  1.00 149.35 ?  426 ARG B NH1 1 
ATOM   6168 N NH2 . ARG B 2 130 ? 56.243  -35.944 70.147  1.00 151.18 ?  426 ARG B NH2 1 
ATOM   6169 N N   . ARG B 2 131 ? 53.895  -33.195 62.164  1.00 119.03 ?  427 ARG B N   1 
ATOM   6170 C CA  . ARG B 2 131 ? 54.212  -33.719 60.845  1.00 113.76 ?  427 ARG B CA  1 
ATOM   6171 C C   . ARG B 2 131 ? 54.197  -32.626 59.782  1.00 113.68 ?  427 ARG B C   1 
ATOM   6172 O O   . ARG B 2 131 ? 55.027  -32.628 58.864  1.00 113.72 ?  427 ARG B O   1 
ATOM   6173 C CB  . ARG B 2 131 ? 53.217  -34.825 60.516  1.00 111.27 ?  427 ARG B CB  1 
ATOM   6174 C CG  . ARG B 2 131 ? 53.208  -35.930 61.543  1.00 112.81 ?  427 ARG B CG  1 
ATOM   6175 C CD  . ARG B 2 131 ? 52.266  -37.031 61.135  1.00 112.08 ?  427 ARG B CD  1 
ATOM   6176 N NE  . ARG B 2 131 ? 50.997  -36.916 61.836  1.00 115.90 ?  427 ARG B NE  1 
ATOM   6177 C CZ  . ARG B 2 131 ? 49.967  -37.730 61.637  1.00 124.83 ?  427 ARG B CZ  1 
ATOM   6178 N NH1 . ARG B 2 131 ? 50.050  -38.706 60.734  1.00 120.74 ?  427 ARG B NH1 1 
ATOM   6179 N NH2 . ARG B 2 131 ? 48.847  -37.554 62.333  1.00 129.24 ?  427 ARG B NH2 1 
ATOM   6180 N N   . PHE B 2 132 ? 53.255  -31.698 59.878  1.00 110.53 ?  428 PHE B N   1 
ATOM   6181 C CA  . PHE B 2 132 ? 53.182  -30.586 58.949  1.00 102.24 ?  428 PHE B CA  1 
ATOM   6182 C C   . PHE B 2 132 ? 53.924  -29.373 59.447  1.00 106.67 ?  428 PHE B C   1 
ATOM   6183 O O   . PHE B 2 132 ? 53.920  -28.336 58.777  1.00 108.19 ?  428 PHE B O   1 
ATOM   6184 C CB  . PHE B 2 132 ? 51.733  -30.226 58.667  1.00 99.66  ?  428 PHE B CB  1 
ATOM   6185 C CG  . PHE B 2 132 ? 51.115  -31.113 57.674  1.00 99.45  ?  428 PHE B CG  1 
ATOM   6186 C CD1 . PHE B 2 132 ? 49.754  -31.122 57.481  1.00 98.59  ?  428 PHE B CD1 1 
ATOM   6187 C CD2 . PHE B 2 132 ? 51.916  -31.967 56.930  1.00 97.44  ?  428 PHE B CD2 1 
ATOM   6188 C CE1 . PHE B 2 132 ? 49.195  -31.963 56.545  1.00 103.85 ?  428 PHE B CE1 1 
ATOM   6189 C CE2 . PHE B 2 132 ? 51.376  -32.802 56.003  1.00 96.97  ?  428 PHE B CE2 1 
ATOM   6190 C CZ  . PHE B 2 132 ? 50.010  -32.810 55.804  1.00 101.47 ?  428 PHE B CZ  1 
ATOM   6191 N N   . ASN B 2 133 ? 54.524  -29.470 60.621  1.00 113.52 ?  429 ASN B N   1 
ATOM   6192 C CA  . ASN B 2 133 ? 55.529  -28.518 61.038  1.00 109.24 ?  429 ASN B CA  1 
ATOM   6193 C C   . ASN B 2 133 ? 54.912  -27.127 61.214  1.00 104.24 ?  429 ASN B C   1 
ATOM   6194 O O   . ASN B 2 133 ? 55.522  -26.115 60.873  1.00 105.14 ?  429 ASN B O   1 
ATOM   6195 C CB  . ASN B 2 133 ? 56.670  -28.519 60.020  1.00 100.85 ?  429 ASN B CB  1 
ATOM   6196 C CG  . ASN B 2 133 ? 57.992  -28.303 60.656  1.00 105.49 ?  429 ASN B CG  1 
ATOM   6197 O OD1 . ASN B 2 133 ? 58.146  -27.409 61.487  1.00 113.02 ?  429 ASN B OD1 1 
ATOM   6198 N ND2 . ASN B 2 133 ? 58.962  -29.150 60.309  1.00 97.02  ?  429 ASN B ND2 1 
ATOM   6199 N N   . ILE B 2 134 ? 53.690  -27.084 61.766  1.00 108.40 ?  430 ILE B N   1 
ATOM   6200 C CA  . ILE B 2 134 ? 52.855  -25.876 61.753  1.00 107.44 ?  430 ILE B CA  1 
ATOM   6201 C C   . ILE B 2 134 ? 53.477  -24.739 62.531  1.00 108.98 ?  430 ILE B C   1 
ATOM   6202 O O   . ILE B 2 134 ? 53.129  -23.569 62.323  1.00 109.85 ?  430 ILE B O   1 
ATOM   6203 C CB  . ILE B 2 134 ? 51.435  -26.178 62.301  1.00 101.10 ?  430 ILE B CB  1 
ATOM   6204 C CG1 . ILE B 2 134 ? 50.696  -27.130 61.391  1.00 104.25 ?  430 ILE B CG1 1 
ATOM   6205 C CG2 . ILE B 2 134 ? 50.576  -24.945 62.340  1.00 99.63  ?  430 ILE B CG2 1 
ATOM   6206 C CD1 . ILE B 2 134 ? 50.901  -28.492 61.716  1.00 113.19 ?  430 ILE B CD1 1 
ATOM   6207 N N   . ASP B 2 135 ? 54.397  -25.045 63.435  1.00 115.07 ?  431 ASP B N   1 
ATOM   6208 C CA  . ASP B 2 135 ? 54.994  -23.970 64.212  1.00 114.94 ?  431 ASP B CA  1 
ATOM   6209 C C   . ASP B 2 135 ? 55.891  -23.080 63.349  1.00 113.92 ?  431 ASP B C   1 
ATOM   6210 O O   . ASP B 2 135 ? 55.827  -21.851 63.473  1.00 111.92 ?  431 ASP B O   1 
ATOM   6211 C CB  . ASP B 2 135 ? 55.750  -24.529 65.422  1.00 120.91 ?  431 ASP B CB  1 
ATOM   6212 C CG  . ASP B 2 135 ? 54.827  -25.185 66.447  1.00 127.74 ?  431 ASP B CG  1 
ATOM   6213 O OD1 . ASP B 2 135 ? 53.590  -25.093 66.272  1.00 124.78 ?  431 ASP B OD1 1 
ATOM   6214 O OD2 . ASP B 2 135 ? 55.322  -25.798 67.416  1.00 129.23 ?  431 ASP B OD2 1 
ATOM   6215 N N   . GLU B 2 136 ? 56.728  -23.660 62.462  1.00 110.13 ?  432 GLU B N   1 
ATOM   6216 C CA  . GLU B 2 136 ? 57.627  -22.794 61.704  1.00 111.13 ?  432 GLU B CA  1 
ATOM   6217 C C   . GLU B 2 136 ? 56.801  -22.046 60.684  1.00 109.53 ?  432 GLU B C   1 
ATOM   6218 O O   . GLU B 2 136 ? 57.173  -20.952 60.264  1.00 110.67 ?  432 GLU B O   1 
ATOM   6219 C CB  . GLU B 2 136 ? 58.736  -23.562 60.951  1.00 105.54 ?  432 GLU B CB  1 
ATOM   6220 C CG  . GLU B 2 136 ? 59.493  -24.716 61.809  1.00 109.62 ?  432 GLU B CG  1 
ATOM   6221 C CD  . GLU B 2 136 ? 60.733  -25.314 61.184  1.00 109.40 ?  432 GLU B CD  1 
ATOM   6222 O OE1 . GLU B 2 136 ? 61.161  -24.664 60.276  1.00 106.53 ?  432 GLU B OE1 1 
ATOM   6223 O OE2 . GLU B 2 136 ? 61.169  -26.478 61.414  1.00 115.86 ?  432 GLU B OE2 1 
ATOM   6224 N N   . VAL B 2 137 ? 55.687  -22.652 60.245  1.00 106.19 ?  433 VAL B N   1 
ATOM   6225 C CA  . VAL B 2 137 ? 54.764  -21.978 59.331  1.00 109.30 ?  433 VAL B CA  1 
ATOM   6226 C C   . VAL B 2 137 ? 54.212  -20.710 59.967  1.00 110.24 ?  433 VAL B C   1 
ATOM   6227 O O   . VAL B 2 137 ? 54.260  -19.628 59.367  1.00 110.22 ?  433 VAL B O   1 
ATOM   6228 C CB  . VAL B 2 137 ? 53.629  -22.929 58.892  1.00 106.46 ?  433 VAL B CB  1 
ATOM   6229 C CG1 . VAL B 2 137 ? 52.561  -22.162 58.139  1.00 103.55 ?  433 VAL B CG1 1 
ATOM   6230 C CG2 . VAL B 2 137 ? 54.171  -24.067 58.014  1.00 99.83  ?  433 VAL B CG2 1 
ATOM   6231 N N   . LEU B 2 138 ? 53.663  -20.827 61.180  1.00 110.24 ?  434 LEU B N   1 
ATOM   6232 C CA  . LEU B 2 138 ? 53.122  -19.658 61.872  1.00 112.75 ?  434 LEU B CA  1 
ATOM   6233 C C   . LEU B 2 138 ? 54.194  -18.621 62.173  1.00 112.08 ?  434 LEU B C   1 
ATOM   6234 O O   . LEU B 2 138 ? 54.001  -17.439 61.881  1.00 111.30 ?  434 LEU B O   1 
ATOM   6235 C CB  . LEU B 2 138 ? 52.400  -20.079 63.147  1.00 107.19 ?  434 LEU B CB  1 
ATOM   6236 C CG  . LEU B 2 138 ? 51.056  -20.672 62.763  1.00 107.63 ?  434 LEU B CG  1 
ATOM   6237 C CD1 . LEU B 2 138 ? 50.355  -21.383 63.877  1.00 100.16 ?  434 LEU B CD1 1 
ATOM   6238 C CD2 . LEU B 2 138 ? 50.265  -19.424 62.382  1.00 108.75 ?  434 LEU B CD2 1 
ATOM   6239 N N   . GLN B 2 139 ? 55.308  -19.018 62.792  1.00 111.80 ?  435 GLN B N   1 
ATOM   6240 C CA  . GLN B 2 139 ? 56.488  -18.149 62.772  1.00 114.63 ?  435 GLN B CA  1 
ATOM   6241 C C   . GLN B 2 139 ? 56.692  -17.391 61.487  1.00 114.22 ?  435 GLN B C   1 
ATOM   6242 O O   . GLN B 2 139 ? 56.974  -16.191 61.529  1.00 114.74 ?  435 GLN B O   1 
ATOM   6243 C CB  . GLN B 2 139 ? 57.748  -18.923 63.084  1.00 114.50 ?  435 GLN B CB  1 
ATOM   6244 C CG  . GLN B 2 139 ? 58.133  -18.914 64.604  1.00 122.08 ?  435 GLN B CG  1 
ATOM   6245 C CD  . GLN B 2 139 ? 59.151  -19.944 64.797  1.00 127.29 ?  435 GLN B CD  1 
ATOM   6246 O OE1 . GLN B 2 139 ? 59.372  -20.821 63.928  1.00 124.25 ?  435 GLN B OE1 1 
ATOM   6247 N NE2 . GLN B 2 139 ? 59.927  -19.793 65.857  1.00 129.90 ?  435 GLN B NE2 1 
ATOM   6248 N N   . GLU B 2 140 ? 56.664  -18.087 60.371  1.00 114.95 ?  436 GLU B N   1 
ATOM   6249 C CA  . GLU B 2 140 ? 57.027  -17.564 59.079  1.00 112.63 ?  436 GLU B CA  1 
ATOM   6250 C C   . GLU B 2 140 ? 55.937  -16.633 58.557  1.00 113.39 ?  436 GLU B C   1 
ATOM   6251 O O   . GLU B 2 140 ? 56.237  -15.735 57.759  1.00 111.22 ?  436 GLU B O   1 
ATOM   6252 C CB  . GLU B 2 140 ? 57.292  -18.803 58.201  1.00 109.05 ?  436 GLU B CB  1 
ATOM   6253 C CG  . GLU B 2 140 ? 57.898  -18.772 56.794  1.00 110.10 ?  436 GLU B CG  1 
ATOM   6254 C CD  . GLU B 2 140 ? 59.264  -18.112 56.696  1.00 116.89 ?  436 GLU B CD  1 
ATOM   6255 O OE1 . GLU B 2 140 ? 59.696  -17.388 57.633  1.00 123.75 ?  436 GLU B OE1 1 
ATOM   6256 O OE2 . GLU B 2 140 ? 59.963  -18.440 55.716  1.00 113.32 ?  436 GLU B OE2 1 
ATOM   6257 N N   . TRP B 2 141 ? 54.681  -16.827 59.006  1.00 112.44 ?  437 TRP B N   1 
ATOM   6258 C CA  . TRP B 2 141 ? 53.570  -15.916 58.726  1.00 113.75 ?  437 TRP B CA  1 
ATOM   6259 C C   . TRP B 2 141 ? 53.621  -14.662 59.583  1.00 118.57 ?  437 TRP B C   1 
ATOM   6260 O O   . TRP B 2 141 ? 53.152  -13.603 59.161  1.00 120.10 ?  437 TRP B O   1 
ATOM   6261 C CB  . TRP B 2 141 ? 52.233  -16.628 58.970  1.00 113.04 ?  437 TRP B CB  1 
ATOM   6262 C CG  . TRP B 2 141 ? 51.012  -15.732 58.866  1.00 114.84 ?  437 TRP B CG  1 
ATOM   6263 C CD1 . TRP B 2 141 ? 50.266  -15.504 57.741  1.00 115.91 ?  437 TRP B CD1 1 
ATOM   6264 C CD2 . TRP B 2 141 ? 50.369  -14.993 59.923  1.00 118.42 ?  437 TRP B CD2 1 
ATOM   6265 N NE1 . TRP B 2 141 ? 49.224  -14.648 58.019  1.00 117.12 ?  437 TRP B NE1 1 
ATOM   6266 C CE2 . TRP B 2 141 ? 49.260  -14.321 59.347  1.00 117.96 ?  437 TRP B CE2 1 
ATOM   6267 C CE3 . TRP B 2 141 ? 50.627  -14.820 61.288  1.00 117.50 ?  437 TRP B CE3 1 
ATOM   6268 C CZ2 . TRP B 2 141 ? 48.412  -13.498 60.086  1.00 116.97 ?  437 TRP B CZ2 1 
ATOM   6269 C CZ3 . TRP B 2 141 ? 49.779  -13.997 62.022  1.00 117.66 ?  437 TRP B CZ3 1 
ATOM   6270 C CH2 . TRP B 2 141 ? 48.684  -13.349 61.417  1.00 116.21 ?  437 TRP B CH2 1 
ATOM   6271 N N   . GLU B 2 142 ? 54.145  -14.761 60.801  1.00 117.36 ?  438 GLU B N   1 
ATOM   6272 C CA  . GLU B 2 142 ? 54.219  -13.564 61.622  1.00 118.12 ?  438 GLU B CA  1 
ATOM   6273 C C   . GLU B 2 142 ? 55.249  -12.586 61.076  1.00 120.19 ?  438 GLU B C   1 
ATOM   6274 O O   . GLU B 2 142 ? 55.116  -11.370 61.276  1.00 120.72 ?  438 GLU B O   1 
ATOM   6275 C CB  . GLU B 2 142 ? 54.507  -13.944 63.070  1.00 118.92 ?  438 GLU B CB  1 
ATOM   6276 C CG  . GLU B 2 142 ? 53.281  -14.539 63.744  1.00 121.49 ?  438 GLU B CG  1 
ATOM   6277 C CD  . GLU B 2 142 ? 53.546  -15.058 65.143  1.00 122.33 ?  438 GLU B CD  1 
ATOM   6278 O OE1 . GLU B 2 142 ? 54.729  -15.247 65.498  1.00 124.63 ?  438 GLU B OE1 1 
ATOM   6279 O OE2 . GLU B 2 142 ? 52.563  -15.299 65.877  1.00 119.52 ?  438 GLU B OE2 1 
ATOM   6280 N N   . ALA B 2 143 ? 56.249  -13.089 60.345  1.00 114.59 ?  439 ALA B N   1 
ATOM   6281 C CA  . ALA B 2 143 ? 57.262  -12.209 59.777  1.00 115.98 ?  439 ALA B CA  1 
ATOM   6282 C C   . ALA B 2 143 ? 56.676  -11.239 58.749  1.00 121.74 ?  439 ALA B C   1 
ATOM   6283 O O   . ALA B 2 143 ? 57.233  -10.156 58.542  1.00 123.69 ?  439 ALA B O   1 
ATOM   6284 C CB  . ALA B 2 143 ? 58.386  -13.040 59.166  1.00 113.81 ?  439 ALA B CB  1 
ATOM   6285 N N   . GLU B 2 144 ? 55.559  -11.583 58.104  1.00 124.92 ?  440 GLU B N   1 
ATOM   6286 C CA  . GLU B 2 144 ? 54.897  -10.627 57.204  1.00 123.61 ?  440 GLU B CA  1 
ATOM   6287 C C   . GLU B 2 144 ? 54.184  -9.517  57.992  1.00 122.75 ?  440 GLU B C   1 
ATOM   6288 O O   . GLU B 2 144 ? 53.588  -9.759  59.052  1.00 123.33 ?  440 GLU B O   1 
ATOM   6289 C CB  . GLU B 2 144 ? 53.897  -11.334 56.263  1.00 130.48 ?  440 GLU B CB  1 
ATOM   6290 C CG  . GLU B 2 144 ? 52.633  -11.883 56.940  1.00 128.22 ?  440 GLU B CG  1 
ATOM   6291 C CD  . GLU B 2 144 ? 51.489  -10.884 57.049  1.00 126.56 ?  440 GLU B CD  1 
ATOM   6292 O OE1 . GLU B 2 144 ? 51.350  -10.025 56.154  1.00 125.46 ?  440 GLU B OE1 1 
ATOM   6293 O OE2 . GLU B 2 144 ? 50.749  -10.947 58.057  1.00 124.25 ?  440 GLU B OE2 1 
HETATM 6294 C C4  . ZSI C 3 .   ? -6.024  52.771  85.357  1.00 81.98  ?  901 ZSI A C4  1 
HETATM 6295 C C14 . ZSI C 3 .   ? -6.564  61.731  79.327  1.00 70.69  ?  901 ZSI A C14 1 
HETATM 6296 C C5  . ZSI C 3 .   ? -7.298  52.832  84.859  1.00 80.37  ?  901 ZSI A C5  1 
HETATM 6297 C C6  . ZSI C 3 .   ? -7.659  53.880  84.045  1.00 85.96  ?  901 ZSI A C6  1 
HETATM 6298 C C11 . ZSI C 3 .   ? -7.391  59.284  82.044  1.00 74.44  ?  901 ZSI A C11 1 
HETATM 6299 C C7  . ZSI C 3 .   ? -6.770  54.885  83.735  1.00 81.28  ?  901 ZSI A C7  1 
HETATM 6300 C C8  . ZSI C 3 .   ? -7.331  55.940  82.811  1.00 80.36  ?  901 ZSI A C8  1 
HETATM 6301 C C9  . ZSI C 3 .   ? -6.490  56.356  81.623  1.00 79.97  ?  901 ZSI A C9  1 
HETATM 6302 C C10 . ZSI C 3 .   ? -7.523  57.256  80.979  1.00 82.32  ?  901 ZSI A C10 1 
HETATM 6303 C C12 . ZSI C 3 .   ? -7.277  59.869  80.805  1.00 70.52  ?  901 ZSI A C12 1 
HETATM 6304 C C13 . ZSI C 3 .   ? -6.686  61.089  80.674  1.00 77.48  ?  901 ZSI A C13 1 
HETATM 6305 N N1  . ZSI C 3 .   ? -2.782  54.311  85.427  1.00 84.97  ?  901 ZSI A N1  1 
HETATM 6306 N N2  . ZSI C 3 .   ? -7.990  58.067  82.068  1.00 76.62  ?  901 ZSI A N2  1 
HETATM 6307 C C3  . ZSI C 3 .   ? -5.109  53.755  85.047  1.00 86.69  ?  901 ZSI A C3  1 
HETATM 6308 N N3  . ZSI C 3 .   ? -7.052  59.258  84.413  1.00 76.64  ?  901 ZSI A N3  1 
HETATM 6309 C C1  . ZSI C 3 .   ? -1.425  53.889  85.702  1.00 77.85  ?  901 ZSI A C1  1 
HETATM 6310 C C15 . ZSI C 3 .   ? -6.199  61.751  81.839  1.00 71.60  ?  901 ZSI A C15 1 
HETATM 6311 C C16 . ZSI C 3 .   ? -5.549  63.092  81.694  1.00 61.86  ?  901 ZSI A C16 1 
HETATM 6312 C C17 . ZSI C 3 .   ? -6.320  61.154  83.064  1.00 70.82  ?  901 ZSI A C17 1 
HETATM 6313 C C18 . ZSI C 3 .   ? -6.918  59.907  83.176  1.00 77.13  ?  901 ZSI A C18 1 
HETATM 6314 C C19 . ZSI C 3 .   ? -6.450  59.869  85.616  1.00 70.16  ?  901 ZSI A C19 1 
HETATM 6315 C C2  . ZSI C 3 .   ? -3.786  53.504  85.691  1.00 85.69  ?  901 ZSI A C2  1 
HETATM 6316 C C20 . ZSI C 3 .   ? -7.313  60.886  86.291  1.00 69.29  ?  901 ZSI A C20 1 
HETATM 6317 C C21 . ZSI C 3 .   ? -6.504  61.783  87.222  1.00 67.09  ?  901 ZSI A C21 1 
HETATM 6318 C C22 . ZSI C 3 .   ? -7.309  62.489  88.303  1.00 65.68  ?  901 ZSI A C22 1 
HETATM 6319 C C23 . ZSI C 3 .   ? -6.460  63.415  89.132  1.00 62.45  ?  901 ZSI A C23 1 
HETATM 6320 C C24 . ZSI C 3 .   ? -6.175  69.686  89.730  1.00 57.51  ?  901 ZSI A C24 1 
HETATM 6321 C C25 . ZSI C 3 .   ? -6.800  71.019  89.467  1.00 56.63  ?  901 ZSI A C25 1 
HETATM 6322 C C26 . ZSI C 3 .   ? -6.138  73.072  88.776  1.00 59.58  ?  901 ZSI A C26 1 
HETATM 6323 C C27 . ZSI C 3 .   ? -3.890  73.692  88.044  1.00 57.20  ?  901 ZSI A C27 1 
HETATM 6324 C C28 . ZSI C 3 .   ? -3.690  75.599  88.921  1.00 59.94  ?  901 ZSI A C28 1 
HETATM 6325 C C29 . ZSI C 3 .   ? -3.344  76.867  89.398  1.00 59.10  ?  901 ZSI A C29 1 
HETATM 6326 C C30 . ZSI C 3 .   ? -5.417  76.925  90.390  1.00 56.74  ?  901 ZSI A C30 1 
HETATM 6327 C C31 . ZSI C 3 .   ? -4.926  75.132  89.254  1.00 54.48  ?  901 ZSI A C31 1 
HETATM 6328 C C32 . ZSI C 3 .   ? -6.530  72.372  87.499  1.00 60.94  ?  901 ZSI A C32 1 
HETATM 6329 C C33 . ZSI C 3 .   ? -7.335  71.209  88.056  1.00 59.83  ?  901 ZSI A C33 1 
HETATM 6330 C C34 . ZSI C 3 .   ? -7.662  58.057  84.499  1.00 75.70  ?  901 ZSI A C34 1 
HETATM 6331 C C35 . ZSI C 3 .   ? -9.028  56.854  85.737  1.00 79.67  ?  901 ZSI A C35 1 
HETATM 6332 C C36 . ZSI C 3 .   ? -9.420  56.793  83.448  1.00 77.60  ?  901 ZSI A C36 1 
HETATM 6333 C C37 . ZSI C 3 .   ? -8.014  57.259  83.274  1.00 80.14  ?  901 ZSI A C37 1 
HETATM 6334 C C38 . ZSI C 3 .   ? -5.476  54.811  84.223  1.00 84.42  ?  901 ZSI A C38 1 
HETATM 6335 N N10 . ZSI C 3 .   ? -9.788  56.508  84.681  1.00 78.21  ?  901 ZSI A N10 1 
HETATM 6336 N N4  . ZSI C 3 .   ? -5.023  73.913  88.678  1.00 55.93  ?  901 ZSI A N4  1 
HETATM 6337 N N5  . ZSI C 3 .   ? -3.040  74.672  88.140  1.00 57.84  ?  901 ZSI A N5  1 
HETATM 6338 N N6  . ZSI C 3 .   ? -2.190  77.459  89.160  1.00 46.45  ?  901 ZSI A N6  1 
HETATM 6339 N N7  . ZSI C 3 .   ? -4.247  77.512  90.149  1.00 53.03  ?  901 ZSI A N7  1 
HETATM 6340 N N8  . ZSI C 3 .   ? -5.856  75.750  89.980  1.00 63.76  ?  901 ZSI A N8  1 
HETATM 6341 N N9  . ZSI C 3 .   ? -7.996  57.628  85.655  1.00 73.38  ?  901 ZSI A N9  1 
HETATM 6342 O O1  . ZSI C 3 .   ? -3.633  52.557  86.441  1.00 91.25  ?  901 ZSI A O1  1 
HETATM 6343 O O10 . ZSI C 3 .   ? -5.735  67.834  87.659  1.00 51.40  ?  901 ZSI A O10 1 
HETATM 6344 O O11 . ZSI C 3 .   ? -7.873  66.686  88.362  1.00 65.99  -1 901 ZSI A O11 1 
HETATM 6345 O O12 . ZSI C 3 .   ? -7.142  68.695  89.465  1.00 70.03  ?  901 ZSI A O12 1 
HETATM 6346 O O13 . ZSI C 3 .   ? -5.787  72.019  89.609  1.00 62.02  ?  901 ZSI A O13 1 
HETATM 6347 O O14 . ZSI C 3 .   ? -7.323  73.226  86.720  1.00 61.57  ?  901 ZSI A O14 1 
HETATM 6348 O O15 . ZSI C 3 .   ? -8.706  71.516  88.145  1.00 66.75  ?  901 ZSI A O15 1 
HETATM 6349 O O16 . ZSI C 3 .   ? -9.340  56.431  86.813  1.00 74.48  ?  901 ZSI A O16 1 
HETATM 6350 O O17 . ZSI C 3 .   ? -10.171 56.661  82.515  1.00 75.22  ?  901 ZSI A O17 1 
HETATM 6351 O O2  . ZSI C 3 .   ? -8.603  56.527  80.522  1.00 80.05  ?  901 ZSI A O2  1 
HETATM 6352 O O3  . ZSI C 3 .   ? -7.793  61.677  85.285  1.00 66.36  ?  901 ZSI A O3  1 
HETATM 6353 O O4  . ZSI C 3 .   ? -5.538  61.029  87.858  1.00 57.97  ?  901 ZSI A O4  1 
HETATM 6354 O O5  . ZSI C 3 .   ? -8.325  63.238  87.664  1.00 69.73  ?  901 ZSI A O5  1 
HETATM 6355 O O6  . ZSI C 3 .   ? -7.151  64.576  89.604  1.00 64.00  ?  901 ZSI A O6  1 
HETATM 6356 O O7  . ZSI C 3 .   ? -7.546  65.907  91.537  1.00 63.27  ?  901 ZSI A O7  1 
HETATM 6357 O O8  . ZSI C 3 .   ? -5.352  64.764  91.285  1.00 56.13  -1 901 ZSI A O8  1 
HETATM 6358 O O9  . ZSI C 3 .   ? -5.932  66.641  89.795  1.00 56.81  ?  901 ZSI A O9  1 
HETATM 6359 P P1  . ZSI C 3 .   ? -6.466  65.468  90.675  1.00 59.84  ?  901 ZSI A P1  1 
HETATM 6360 P P2  . ZSI C 3 .   ? -6.678  67.441  88.686  1.00 62.09  ?  901 ZSI A P2  1 
HETATM 6361 K K   . K   D 4 .   ? -7.254  41.371  72.465  1.00 145.55 ?  902 K   A K   1 
# 
