data_9GFI
# 
_entry.id   9GFI 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9GFI         pdb_00009gfi 10.2210/pdb9gfi/pdb 
WWPDB D_1292140911 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-02-12 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
loop_
_database_PDB_caveat.id 
_database_PDB_caveat.text 
1  'HIS C 1 HAS WRONG CHIRALITY AT ATOM CA'    
2  'LYS C 2 HAS WRONG CHIRALITY AT ATOM CA'    
3  'ILE C 3 HAS WRONG CHIRALITY AT ATOM CA'    
4  'ILE C 3 HAS WRONG CHIRALITY AT ATOM CB'    
5  'LEU C 4 HAS WRONG CHIRALITY AT ATOM CA'    
6  'NLE C 5 HAS WRONG CHIRALITY AT ATOM CA'    
7  'ARG C 6 HAS WRONG CHIRALITY AT ATOM CA'    
8  'LEU C 7 HAS WRONG CHIRALITY AT ATOM CA'    
9  'LEU C 8 HAS WRONG CHIRALITY AT ATOM CA'    
10 'HRG C 9 HAS WRONG CHIRALITY AT ATOM CA'    
11 'A1IM7 C 10 HAS WRONG CHIRALITY AT ATOM CA' 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9GFI 
_pdbx_database_status.recvd_initial_deposition_date   2024-08-09 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              g.guichard@iecb.u-bordeaux.fr 
_pdbx_contact_author.name_first         Gilles 
_pdbx_contact_author.name_last          Guichard 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-2584-7502 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Perdriau, C.'     1  ?                   
'Luton, A.'        2  ?                   
'Zimmeter, K.'     3  ?                   
'Neuville, M.'     4  ?                   
'Saragaglia, C.'   5  ?                   
'Peluso-lltis, C.' 6  ?                   
'Osz, J.'          7  ?                   
'Kauffmann, B.'    8  0000-0002-2932-3255 
'Collie, G.'       9  0000-0002-0406-922X 
'Rochel, N.'       10 0000-0002-3573-5889 
'Guichard, G.'     11 0000-0002-2584-7502 
'Pasco, M.'        12 0000-0002-1556-2802 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   GE 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Angew.Chem.Int.Ed.Engl. 
_citation.journal_id_ASTM           ACIEAY 
_citation.journal_id_CSD            0179 
_citation.journal_id_ISSN           1521-3773 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            64 
_citation.language                  ? 
_citation.page_first                e202416348 
_citation.page_last                 e202416348 
_citation.title                     'Guanidinium-Stapled Helical Peptides for Targeting Protein-Protein Interactions.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1002/anie.202416348 
_citation.pdbx_database_id_PubMed   39714600 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Perdriau, C.'     1  ?                   
primary 'Luton, A.'        2  ?                   
primary 'Zimmeter, K.'     3  0009-0000-2289-8091 
primary 'Neuville, M.'     4  ?                   
primary 'Saragaglia, C.'   5  0000-0002-9686-8992 
primary 'Peluso-Iltis, C.' 6  ?                   
primary 'Osz, J.'          7  ?                   
primary 'Kauffmann, B.'    8  0000-0002-2932-3255 
primary 'Collie, G.W.'     9  0000-0002-0406-922X 
primary 'Rochel, N.'       10 0000-0002-3573-5889 
primary 'Guichard, G.'     11 0000-0002-2584-7502 
primary 'Pasco, M.'        12 0000-0002-1556-2802 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Retinoic acid receptor alpha'                                                           26700.170 1  ? ? ? ? 
2 polymer     syn 'Stapled peptide-like ligand'                                                            1320.693  1  ? ? ? ? 
3 non-polymer syn '4-{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino}benzoic acid' 351.439   1  ? ? ? ? 
4 water       nat water                                                                                    18.015    55 ? ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'RAR-alpha,Nuclear receptor subfamily 1 group B member 1' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no  
;LTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQIT
LLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDR
QDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLE
;
;LTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQIT
LLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDR
QDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLE
;
A ? 
2 'polypeptide(L)' no yes 'HKIL(NLE)RLL(HRG)(A1IM7)' HKILLRLLRX B ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
3 '4-{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino}benzoic acid' EQN 
4 water                                                                                    HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   LEU   n 
1 2   THR   n 
1 3   PRO   n 
1 4   GLU   n 
1 5   VAL   n 
1 6   GLY   n 
1 7   GLU   n 
1 8   LEU   n 
1 9   ILE   n 
1 10  GLU   n 
1 11  LYS   n 
1 12  VAL   n 
1 13  ARG   n 
1 14  LYS   n 
1 15  ALA   n 
1 16  HIS   n 
1 17  GLN   n 
1 18  GLU   n 
1 19  THR   n 
1 20  PHE   n 
1 21  PRO   n 
1 22  ALA   n 
1 23  LEU   n 
1 24  CYS   n 
1 25  GLN   n 
1 26  LEU   n 
1 27  GLY   n 
1 28  LYS   n 
1 29  TYR   n 
1 30  THR   n 
1 31  THR   n 
1 32  ASN   n 
1 33  ASN   n 
1 34  SER   n 
1 35  SER   n 
1 36  GLU   n 
1 37  GLN   n 
1 38  ARG   n 
1 39  VAL   n 
1 40  SER   n 
1 41  LEU   n 
1 42  ASP   n 
1 43  ILE   n 
1 44  ASP   n 
1 45  LEU   n 
1 46  TRP   n 
1 47  ASP   n 
1 48  LYS   n 
1 49  PHE   n 
1 50  SER   n 
1 51  GLU   n 
1 52  LEU   n 
1 53  SER   n 
1 54  THR   n 
1 55  LYS   n 
1 56  CYS   n 
1 57  ILE   n 
1 58  ILE   n 
1 59  LYS   n 
1 60  THR   n 
1 61  VAL   n 
1 62  GLU   n 
1 63  PHE   n 
1 64  ALA   n 
1 65  LYS   n 
1 66  GLN   n 
1 67  LEU   n 
1 68  PRO   n 
1 69  GLY   n 
1 70  PHE   n 
1 71  THR   n 
1 72  THR   n 
1 73  LEU   n 
1 74  THR   n 
1 75  ILE   n 
1 76  ALA   n 
1 77  ASP   n 
1 78  GLN   n 
1 79  ILE   n 
1 80  THR   n 
1 81  LEU   n 
1 82  LEU   n 
1 83  LYS   n 
1 84  ALA   n 
1 85  ALA   n 
1 86  CYS   n 
1 87  LEU   n 
1 88  ASP   n 
1 89  ILE   n 
1 90  LEU   n 
1 91  ILE   n 
1 92  LEU   n 
1 93  ARG   n 
1 94  ILE   n 
1 95  CYS   n 
1 96  THR   n 
1 97  ARG   n 
1 98  TYR   n 
1 99  THR   n 
1 100 PRO   n 
1 101 GLU   n 
1 102 GLN   n 
1 103 ASP   n 
1 104 THR   n 
1 105 MET   n 
1 106 THR   n 
1 107 PHE   n 
1 108 SER   n 
1 109 ASP   n 
1 110 GLY   n 
1 111 LEU   n 
1 112 THR   n 
1 113 LEU   n 
1 114 ASN   n 
1 115 ARG   n 
1 116 THR   n 
1 117 GLN   n 
1 118 MET   n 
1 119 HIS   n 
1 120 ASN   n 
1 121 ALA   n 
1 122 GLY   n 
1 123 PHE   n 
1 124 GLY   n 
1 125 PRO   n 
1 126 LEU   n 
1 127 THR   n 
1 128 ASP   n 
1 129 LEU   n 
1 130 VAL   n 
1 131 PHE   n 
1 132 ALA   n 
1 133 PHE   n 
1 134 ALA   n 
1 135 ASN   n 
1 136 GLN   n 
1 137 LEU   n 
1 138 LEU   n 
1 139 PRO   n 
1 140 LEU   n 
1 141 GLU   n 
1 142 MET   n 
1 143 ASP   n 
1 144 ASP   n 
1 145 ALA   n 
1 146 GLU   n 
1 147 THR   n 
1 148 GLY   n 
1 149 LEU   n 
1 150 LEU   n 
1 151 SER   n 
1 152 ALA   n 
1 153 ILE   n 
1 154 CYS   n 
1 155 LEU   n 
1 156 ILE   n 
1 157 CYS   n 
1 158 GLY   n 
1 159 ASP   n 
1 160 ARG   n 
1 161 GLN   n 
1 162 ASP   n 
1 163 LEU   n 
1 164 GLU   n 
1 165 GLN   n 
1 166 PRO   n 
1 167 ASP   n 
1 168 ARG   n 
1 169 VAL   n 
1 170 ASP   n 
1 171 MET   n 
1 172 LEU   n 
1 173 GLN   n 
1 174 GLU   n 
1 175 PRO   n 
1 176 LEU   n 
1 177 LEU   n 
1 178 GLU   n 
1 179 ALA   n 
1 180 LEU   n 
1 181 LYS   n 
1 182 VAL   n 
1 183 TYR   n 
1 184 VAL   n 
1 185 ARG   n 
1 186 LYS   n 
1 187 ARG   n 
1 188 ARG   n 
1 189 PRO   n 
1 190 SER   n 
1 191 ARG   n 
1 192 PRO   n 
1 193 HIS   n 
1 194 MET   n 
1 195 PHE   n 
1 196 PRO   n 
1 197 LYS   n 
1 198 MET   n 
1 199 LEU   n 
1 200 MET   n 
1 201 LYS   n 
1 202 ILE   n 
1 203 THR   n 
1 204 ASP   n 
1 205 LEU   n 
1 206 ARG   n 
1 207 SER   n 
1 208 ILE   n 
1 209 SER   n 
1 210 ALA   n 
1 211 LYS   n 
1 212 GLY   n 
1 213 ALA   n 
1 214 GLU   n 
1 215 ARG   n 
1 216 VAL   n 
1 217 ILE   n 
1 218 THR   n 
1 219 LEU   n 
1 220 LYS   n 
1 221 MET   n 
1 222 GLU   n 
1 223 ILE   n 
1 224 PRO   n 
1 225 GLY   n 
1 226 SER   n 
1 227 MET   n 
1 228 PRO   n 
1 229 PRO   n 
1 230 LEU   n 
1 231 ILE   n 
1 232 GLN   n 
1 233 GLU   n 
1 234 MET   n 
1 235 LEU   n 
1 236 GLU   n 
2 1   HIS   n 
2 2   LYS   n 
2 3   ILE   n 
2 4   LEU   n 
2 5   NLE   n 
2 6   ARG   n 
2 7   LEU   n 
2 8   LEU   n 
2 9   HRG   n 
2 10  A1IM7 n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   236 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'RARA, NR1B1' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      
;Escherichia coli 'BL21-Gold(DE3)pLysS AG'
;
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     866768 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
_pdbx_entity_src_syn.entity_id              2 
_pdbx_entity_src_syn.pdbx_src_id            1 
_pdbx_entity_src_syn.pdbx_alt_source_flag   sample 
_pdbx_entity_src_syn.pdbx_beg_seq_num       1 
_pdbx_entity_src_syn.pdbx_end_seq_num       10 
_pdbx_entity_src_syn.organism_scientific    'synthetic construct' 
_pdbx_entity_src_syn.organism_common_name   ? 
_pdbx_entity_src_syn.ncbi_taxonomy_id       32630 
_pdbx_entity_src_syn.details                ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1IM7 'L-peptide linking' . 'C-methylamino-glutamic acid'                                                            ? 
'C6 H12 N2 O3'   160.171 
ALA   'L-peptide linking' y ALANINE                                                                                  ? 
'C3 H7 N O2'     89.093  
ARG   'L-peptide linking' y ARGININE                                                                                 ? 
'C6 H15 N4 O2 1' 175.209 
ASN   'L-peptide linking' y ASPARAGINE                                                                               ? 
'C4 H8 N2 O3'    132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID'                                                                          ? 
'C4 H7 N O4'     133.103 
CYS   'L-peptide linking' y CYSTEINE                                                                                 ? 
'C3 H7 N O2 S'   121.158 
EQN   non-polymer         . '4-{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino}benzoic acid' ? 
'C22 H25 N O3'   351.439 
GLN   'L-peptide linking' y GLUTAMINE                                                                                ? 
'C5 H10 N2 O3'   146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID'                                                                          ? 
'C5 H9 N O4'     147.129 
GLY   'peptide linking'   y GLYCINE                                                                                  ? 
'C2 H5 N O2'     75.067  
HIS   'L-peptide linking' y HISTIDINE                                                                                ? 
'C6 H10 N3 O2 1' 156.162 
HOH   non-polymer         . WATER                                                                                    ? 'H2 O' 
18.015  
HRG   'L-peptide linking' n L-HOMOARGININE                                                                           ? 
'C7 H16 N4 O2'   188.228 
ILE   'L-peptide linking' y ISOLEUCINE                                                                               ? 
'C6 H13 N O2'    131.173 
LEU   'L-peptide linking' y LEUCINE                                                                                  ? 
'C6 H13 N O2'    131.173 
LYS   'L-peptide linking' y LYSINE                                                                                   ? 
'C6 H15 N2 O2 1' 147.195 
MET   'L-peptide linking' y METHIONINE                                                                               ? 
'C5 H11 N O2 S'  149.211 
NLE   'L-peptide linking' n NORLEUCINE                                                                               ? 
'C6 H13 N O2'    131.173 
PHE   'L-peptide linking' y PHENYLALANINE                                                                            ? 
'C9 H11 N O2'    165.189 
PRO   'L-peptide linking' y PROLINE                                                                                  ? 
'C5 H9 N O2'     115.130 
SER   'L-peptide linking' y SERINE                                                                                   ? 
'C3 H7 N O3'     105.093 
THR   'L-peptide linking' y THREONINE                                                                                ? 
'C4 H9 N O3'     119.119 
TRP   'L-peptide linking' y TRYPTOPHAN                                                                               ? 
'C11 H12 N2 O2'  204.225 
TYR   'L-peptide linking' y TYROSINE                                                                                 ? 
'C9 H11 N O3'    181.189 
VAL   'L-peptide linking' y VALINE                                                                                   ? 
'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   LEU   1   180 180 LEU   LEU A . n 
A 1 2   THR   2   181 181 THR   THR A . n 
A 1 3   PRO   3   182 182 PRO   PRO A . n 
A 1 4   GLU   4   183 183 GLU   GLU A . n 
A 1 5   VAL   5   184 184 VAL   VAL A . n 
A 1 6   GLY   6   185 185 GLY   GLY A . n 
A 1 7   GLU   7   186 186 GLU   GLU A . n 
A 1 8   LEU   8   187 187 LEU   LEU A . n 
A 1 9   ILE   9   188 188 ILE   ILE A . n 
A 1 10  GLU   10  189 189 GLU   GLU A . n 
A 1 11  LYS   11  190 190 LYS   LYS A . n 
A 1 12  VAL   12  191 191 VAL   VAL A . n 
A 1 13  ARG   13  192 192 ARG   ARG A . n 
A 1 14  LYS   14  193 193 LYS   LYS A . n 
A 1 15  ALA   15  194 194 ALA   ALA A . n 
A 1 16  HIS   16  195 195 HIS   HIS A . n 
A 1 17  GLN   17  196 196 GLN   GLN A . n 
A 1 18  GLU   18  197 197 GLU   GLU A . n 
A 1 19  THR   19  198 198 THR   THR A . n 
A 1 20  PHE   20  199 199 PHE   PHE A . n 
A 1 21  PRO   21  200 200 PRO   PRO A . n 
A 1 22  ALA   22  201 201 ALA   ALA A . n 
A 1 23  LEU   23  202 202 LEU   LEU A . n 
A 1 24  CYS   24  203 203 CYS   CYS A . n 
A 1 25  GLN   25  204 204 GLN   GLN A . n 
A 1 26  LEU   26  205 205 LEU   LEU A . n 
A 1 27  GLY   27  206 206 GLY   GLY A . n 
A 1 28  LYS   28  207 207 LYS   LYS A . n 
A 1 29  TYR   29  208 208 TYR   TYR A . n 
A 1 30  THR   30  209 209 THR   THR A . n 
A 1 31  THR   31  210 210 THR   THR A . n 
A 1 32  ASN   32  211 211 ASN   ASN A . n 
A 1 33  ASN   33  212 212 ASN   ASN A . n 
A 1 34  SER   34  213 213 SER   SER A . n 
A 1 35  SER   35  214 214 SER   SER A . n 
A 1 36  GLU   36  215 215 GLU   GLU A . n 
A 1 37  GLN   37  216 216 GLN   GLN A . n 
A 1 38  ARG   38  217 217 ARG   ARG A . n 
A 1 39  VAL   39  218 218 VAL   VAL A . n 
A 1 40  SER   40  219 219 SER   SER A . n 
A 1 41  LEU   41  220 220 LEU   LEU A . n 
A 1 42  ASP   42  221 221 ASP   ASP A . n 
A 1 43  ILE   43  222 222 ILE   ILE A . n 
A 1 44  ASP   44  223 223 ASP   ASP A . n 
A 1 45  LEU   45  224 224 LEU   LEU A . n 
A 1 46  TRP   46  225 225 TRP   TRP A . n 
A 1 47  ASP   47  226 226 ASP   ASP A . n 
A 1 48  LYS   48  227 227 LYS   LYS A . n 
A 1 49  PHE   49  228 228 PHE   PHE A . n 
A 1 50  SER   50  229 229 SER   SER A . n 
A 1 51  GLU   51  230 230 GLU   GLU A . n 
A 1 52  LEU   52  231 231 LEU   LEU A . n 
A 1 53  SER   53  232 232 SER   SER A . n 
A 1 54  THR   54  233 233 THR   THR A . n 
A 1 55  LYS   55  234 234 LYS   LYS A . n 
A 1 56  CYS   56  235 235 CYS   CYS A . n 
A 1 57  ILE   57  236 236 ILE   ILE A . n 
A 1 58  ILE   58  237 237 ILE   ILE A . n 
A 1 59  LYS   59  238 238 LYS   LYS A . n 
A 1 60  THR   60  239 239 THR   THR A . n 
A 1 61  VAL   61  240 240 VAL   VAL A . n 
A 1 62  GLU   62  241 241 GLU   GLU A . n 
A 1 63  PHE   63  242 242 PHE   PHE A . n 
A 1 64  ALA   64  243 243 ALA   ALA A . n 
A 1 65  LYS   65  244 244 LYS   LYS A . n 
A 1 66  GLN   66  245 245 GLN   GLN A . n 
A 1 67  LEU   67  246 246 LEU   LEU A . n 
A 1 68  PRO   68  247 247 PRO   PRO A . n 
A 1 69  GLY   69  248 248 GLY   GLY A . n 
A 1 70  PHE   70  249 249 PHE   PHE A . n 
A 1 71  THR   71  250 250 THR   THR A . n 
A 1 72  THR   72  251 251 THR   THR A . n 
A 1 73  LEU   73  252 252 LEU   LEU A . n 
A 1 74  THR   74  253 253 THR   THR A . n 
A 1 75  ILE   75  254 254 ILE   ILE A . n 
A 1 76  ALA   76  255 255 ALA   ALA A . n 
A 1 77  ASP   77  256 256 ASP   ASP A . n 
A 1 78  GLN   78  257 257 GLN   GLN A . n 
A 1 79  ILE   79  258 258 ILE   ILE A . n 
A 1 80  THR   80  259 259 THR   THR A . n 
A 1 81  LEU   81  260 260 LEU   LEU A . n 
A 1 82  LEU   82  261 261 LEU   LEU A . n 
A 1 83  LYS   83  262 262 LYS   LYS A . n 
A 1 84  ALA   84  263 263 ALA   ALA A . n 
A 1 85  ALA   85  264 264 ALA   ALA A . n 
A 1 86  CYS   86  265 265 CYS   CYS A . n 
A 1 87  LEU   87  266 266 LEU   LEU A . n 
A 1 88  ASP   88  267 267 ASP   ASP A . n 
A 1 89  ILE   89  268 268 ILE   ILE A . n 
A 1 90  LEU   90  269 269 LEU   LEU A . n 
A 1 91  ILE   91  270 270 ILE   ILE A . n 
A 1 92  LEU   92  271 271 LEU   LEU A . n 
A 1 93  ARG   93  272 272 ARG   ARG A . n 
A 1 94  ILE   94  273 273 ILE   ILE A . n 
A 1 95  CYS   95  274 274 CYS   CYS A . n 
A 1 96  THR   96  275 275 THR   THR A . n 
A 1 97  ARG   97  276 276 ARG   ARG A . n 
A 1 98  TYR   98  277 277 TYR   TYR A . n 
A 1 99  THR   99  278 278 THR   THR A . n 
A 1 100 PRO   100 279 279 PRO   PRO A . n 
A 1 101 GLU   101 280 280 GLU   GLU A . n 
A 1 102 GLN   102 281 281 GLN   GLN A . n 
A 1 103 ASP   103 282 282 ASP   ASP A . n 
A 1 104 THR   104 283 283 THR   THR A . n 
A 1 105 MET   105 284 284 MET   MET A . n 
A 1 106 THR   106 285 285 THR   THR A . n 
A 1 107 PHE   107 286 286 PHE   PHE A . n 
A 1 108 SER   108 287 287 SER   SER A . n 
A 1 109 ASP   109 288 288 ASP   ASP A . n 
A 1 110 GLY   110 289 289 GLY   GLY A . n 
A 1 111 LEU   111 290 290 LEU   LEU A . n 
A 1 112 THR   112 291 291 THR   THR A . n 
A 1 113 LEU   113 292 292 LEU   LEU A . n 
A 1 114 ASN   114 293 293 ASN   ASN A . n 
A 1 115 ARG   115 294 294 ARG   ARG A . n 
A 1 116 THR   116 295 295 THR   THR A . n 
A 1 117 GLN   117 296 296 GLN   GLN A . n 
A 1 118 MET   118 297 297 MET   MET A . n 
A 1 119 HIS   119 298 298 HIS   HIS A . n 
A 1 120 ASN   120 299 299 ASN   ASN A . n 
A 1 121 ALA   121 300 300 ALA   ALA A . n 
A 1 122 GLY   122 301 301 GLY   GLY A . n 
A 1 123 PHE   123 302 302 PHE   PHE A . n 
A 1 124 GLY   124 303 303 GLY   GLY A . n 
A 1 125 PRO   125 304 304 PRO   PRO A . n 
A 1 126 LEU   126 305 305 LEU   LEU A . n 
A 1 127 THR   127 306 306 THR   THR A . n 
A 1 128 ASP   128 307 307 ASP   ASP A . n 
A 1 129 LEU   129 308 308 LEU   LEU A . n 
A 1 130 VAL   130 309 309 VAL   VAL A . n 
A 1 131 PHE   131 310 310 PHE   PHE A . n 
A 1 132 ALA   132 311 311 ALA   ALA A . n 
A 1 133 PHE   133 312 312 PHE   PHE A . n 
A 1 134 ALA   134 313 313 ALA   ALA A . n 
A 1 135 ASN   135 314 314 ASN   ASN A . n 
A 1 136 GLN   136 315 315 GLN   GLN A . n 
A 1 137 LEU   137 316 316 LEU   LEU A . n 
A 1 138 LEU   138 317 317 LEU   LEU A . n 
A 1 139 PRO   139 318 318 PRO   PRO A . n 
A 1 140 LEU   140 319 319 LEU   LEU A . n 
A 1 141 GLU   141 320 320 GLU   GLU A . n 
A 1 142 MET   142 321 321 MET   MET A . n 
A 1 143 ASP   143 322 322 ASP   ASP A . n 
A 1 144 ASP   144 323 323 ASP   ASP A . n 
A 1 145 ALA   145 324 324 ALA   ALA A . n 
A 1 146 GLU   146 325 325 GLU   GLU A . n 
A 1 147 THR   147 326 326 THR   THR A . n 
A 1 148 GLY   148 327 327 GLY   GLY A . n 
A 1 149 LEU   149 328 328 LEU   LEU A . n 
A 1 150 LEU   150 329 329 LEU   LEU A . n 
A 1 151 SER   151 330 330 SER   SER A . n 
A 1 152 ALA   152 331 331 ALA   ALA A . n 
A 1 153 ILE   153 332 332 ILE   ILE A . n 
A 1 154 CYS   154 333 333 CYS   CYS A . n 
A 1 155 LEU   155 334 334 LEU   LEU A . n 
A 1 156 ILE   156 335 335 ILE   ILE A . n 
A 1 157 CYS   157 336 336 CYS   CYS A . n 
A 1 158 GLY   158 337 337 GLY   GLY A . n 
A 1 159 ASP   159 338 338 ASP   ASP A . n 
A 1 160 ARG   160 339 339 ARG   ARG A . n 
A 1 161 GLN   161 340 340 GLN   GLN A . n 
A 1 162 ASP   162 341 341 ASP   ASP A . n 
A 1 163 LEU   163 342 342 LEU   LEU A . n 
A 1 164 GLU   164 343 343 GLU   GLU A . n 
A 1 165 GLN   165 344 344 GLN   GLN A . n 
A 1 166 PRO   166 345 345 PRO   PRO A . n 
A 1 167 ASP   167 346 346 ASP   ASP A . n 
A 1 168 ARG   168 347 347 ARG   ARG A . n 
A 1 169 VAL   169 348 348 VAL   VAL A . n 
A 1 170 ASP   170 349 349 ASP   ASP A . n 
A 1 171 MET   171 350 350 MET   MET A . n 
A 1 172 LEU   172 351 351 LEU   LEU A . n 
A 1 173 GLN   173 352 352 GLN   GLN A . n 
A 1 174 GLU   174 353 353 GLU   GLU A . n 
A 1 175 PRO   175 354 354 PRO   PRO A . n 
A 1 176 LEU   176 355 355 LEU   LEU A . n 
A 1 177 LEU   177 356 356 LEU   LEU A . n 
A 1 178 GLU   178 357 357 GLU   GLU A . n 
A 1 179 ALA   179 358 358 ALA   ALA A . n 
A 1 180 LEU   180 359 359 LEU   LEU A . n 
A 1 181 LYS   181 360 360 LYS   LYS A . n 
A 1 182 VAL   182 361 361 VAL   VAL A . n 
A 1 183 TYR   183 362 362 TYR   TYR A . n 
A 1 184 VAL   184 363 363 VAL   VAL A . n 
A 1 185 ARG   185 364 364 ARG   ARG A . n 
A 1 186 LYS   186 365 365 LYS   LYS A . n 
A 1 187 ARG   187 366 366 ARG   ARG A . n 
A 1 188 ARG   188 367 367 ARG   ARG A . n 
A 1 189 PRO   189 368 368 PRO   PRO A . n 
A 1 190 SER   190 369 369 SER   SER A . n 
A 1 191 ARG   191 370 370 ARG   ARG A . n 
A 1 192 PRO   192 371 371 PRO   PRO A . n 
A 1 193 HIS   193 372 372 HIS   HIS A . n 
A 1 194 MET   194 373 373 MET   MET A . n 
A 1 195 PHE   195 374 374 PHE   PHE A . n 
A 1 196 PRO   196 375 375 PRO   PRO A . n 
A 1 197 LYS   197 376 376 LYS   LYS A . n 
A 1 198 MET   198 377 377 MET   MET A . n 
A 1 199 LEU   199 378 378 LEU   LEU A . n 
A 1 200 MET   200 379 379 MET   MET A . n 
A 1 201 LYS   201 380 380 LYS   LYS A . n 
A 1 202 ILE   202 381 381 ILE   ILE A . n 
A 1 203 THR   203 382 382 THR   THR A . n 
A 1 204 ASP   204 383 383 ASP   ASP A . n 
A 1 205 LEU   205 384 384 LEU   LEU A . n 
A 1 206 ARG   206 385 385 ARG   ARG A . n 
A 1 207 SER   207 386 386 SER   SER A . n 
A 1 208 ILE   208 387 387 ILE   ILE A . n 
A 1 209 SER   209 388 388 SER   SER A . n 
A 1 210 ALA   210 389 389 ALA   ALA A . n 
A 1 211 LYS   211 390 390 LYS   LYS A . n 
A 1 212 GLY   212 391 391 GLY   GLY A . n 
A 1 213 ALA   213 392 392 ALA   ALA A . n 
A 1 214 GLU   214 393 393 GLU   GLU A . n 
A 1 215 ARG   215 394 394 ARG   ARG A . n 
A 1 216 VAL   216 395 395 VAL   VAL A . n 
A 1 217 ILE   217 396 396 ILE   ILE A . n 
A 1 218 THR   218 397 397 THR   THR A . n 
A 1 219 LEU   219 398 398 LEU   LEU A . n 
A 1 220 LYS   220 399 399 LYS   LYS A . n 
A 1 221 MET   221 400 400 MET   MET A . n 
A 1 222 GLU   222 401 401 GLU   GLU A . n 
A 1 223 ILE   223 402 402 ILE   ILE A . n 
A 1 224 PRO   224 403 403 PRO   PRO A . n 
A 1 225 GLY   225 404 404 GLY   GLY A . n 
A 1 226 SER   226 405 405 SER   SER A . n 
A 1 227 MET   227 406 406 MET   MET A . n 
A 1 228 PRO   228 407 407 PRO   PRO A . n 
A 1 229 PRO   229 408 408 PRO   PRO A . n 
A 1 230 LEU   230 409 409 LEU   LEU A . n 
A 1 231 ILE   231 410 410 ILE   ILE A . n 
A 1 232 GLN   232 411 411 GLN   GLN A . n 
A 1 233 GLU   233 412 412 GLU   GLU A . n 
A 1 234 MET   234 413 413 MET   MET A . n 
A 1 235 LEU   235 414 414 LEU   LEU A . n 
A 1 236 GLU   236 415 415 GLU   GLU A . n 
B 2 1   HIS   1   1   1   HIS   220 B . n 
B 2 2   LYS   2   2   1   LYS   220 B . n 
B 2 3   ILE   3   3   1   ILE   220 B . n 
B 2 4   LEU   4   4   1   LEU   220 B . n 
B 2 5   NLE   5   5   1   NLE   220 B . n 
B 2 6   ARG   6   6   1   ARG   220 B . n 
B 2 7   LEU   7   7   1   LEU   220 B . n 
B 2 8   LEU   8   8   1   LEU   220 B . n 
B 2 9   HRG   9   9   1   HRG   220 B . n 
B 2 10  A1IM7 10  10  1   A1IM7 220 B . n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 EQN   ? ? EQN   ? ? 'SUBJECT OF INVESTIGATION' ? 
2 A1IM7 ? ? A1IM7 ? ? 'SUBJECT OF INVESTIGATION' ? 
3 HRG   ? ? HRG   ? ? 'SUBJECT OF INVESTIGATION' ? 
4 NLE   ? ? NLE   ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 3 EQN 1  501 501 EQN EQN A . 
D 4 HOH 1  601 15  HOH HOH A . 
D 4 HOH 2  602 27  HOH HOH A . 
D 4 HOH 3  603 29  HOH HOH A . 
D 4 HOH 4  604 16  HOH HOH A . 
D 4 HOH 5  605 20  HOH HOH A . 
D 4 HOH 6  606 34  HOH HOH A . 
D 4 HOH 7  607 5   HOH HOH A . 
D 4 HOH 8  608 24  HOH HOH A . 
D 4 HOH 9  609 7   HOH HOH A . 
D 4 HOH 10 610 8   HOH HOH A . 
D 4 HOH 11 611 43  HOH HOH A . 
D 4 HOH 12 612 3   HOH HOH A . 
D 4 HOH 13 613 9   HOH HOH A . 
D 4 HOH 14 614 35  HOH HOH A . 
D 4 HOH 15 615 55  HOH HOH A . 
D 4 HOH 16 616 1   HOH HOH A . 
D 4 HOH 17 617 26  HOH HOH A . 
D 4 HOH 18 618 14  HOH HOH A . 
D 4 HOH 19 619 2   HOH HOH A . 
D 4 HOH 20 620 22  HOH HOH A . 
D 4 HOH 21 621 23  HOH HOH A . 
D 4 HOH 22 622 13  HOH HOH A . 
D 4 HOH 23 623 18  HOH HOH A . 
D 4 HOH 24 624 36  HOH HOH A . 
D 4 HOH 25 625 6   HOH HOH A . 
D 4 HOH 26 626 19  HOH HOH A . 
D 4 HOH 27 627 30  HOH HOH A . 
D 4 HOH 28 628 45  HOH HOH A . 
D 4 HOH 29 629 31  HOH HOH A . 
D 4 HOH 30 630 47  HOH HOH A . 
D 4 HOH 31 631 11  HOH HOH A . 
D 4 HOH 32 632 38  HOH HOH A . 
D 4 HOH 33 633 28  HOH HOH A . 
D 4 HOH 34 634 50  HOH HOH A . 
D 4 HOH 35 635 49  HOH HOH A . 
D 4 HOH 36 636 40  HOH HOH A . 
D 4 HOH 37 637 10  HOH HOH A . 
D 4 HOH 38 638 12  HOH HOH A . 
D 4 HOH 39 639 42  HOH HOH A . 
D 4 HOH 40 640 25  HOH HOH A . 
D 4 HOH 41 641 4   HOH HOH A . 
D 4 HOH 42 642 53  HOH HOH A . 
D 4 HOH 43 643 21  HOH HOH A . 
D 4 HOH 44 644 51  HOH HOH A . 
D 4 HOH 45 645 44  HOH HOH A . 
D 4 HOH 46 646 33  HOH HOH A . 
D 4 HOH 47 647 46  HOH HOH A . 
D 4 HOH 48 648 17  HOH HOH A . 
D 4 HOH 49 649 32  HOH HOH A . 
D 4 HOH 50 650 48  HOH HOH A . 
D 4 HOH 51 651 41  HOH HOH A . 
D 4 HOH 52 652 37  HOH HOH A . 
D 4 HOH 53 653 52  HOH HOH A . 
D 4 HOH 54 654 39  HOH HOH A . 
D 4 HOH 55 655 54  HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A GLN 315 ? CG  ? A GLN 136 CG  
2  1 Y 1 A GLN 315 ? CD  ? A GLN 136 CD  
3  1 Y 1 A GLN 315 ? OE1 ? A GLN 136 OE1 
4  1 Y 1 A GLN 315 ? NE2 ? A GLN 136 NE2 
5  1 Y 1 A ARG 364 ? CG  ? A ARG 185 CG  
6  1 Y 1 A ARG 364 ? CD  ? A ARG 185 CD  
7  1 Y 1 A ARG 364 ? NE  ? A ARG 185 NE  
8  1 Y 1 A ARG 364 ? CZ  ? A ARG 185 CZ  
9  1 Y 1 A ARG 364 ? NH1 ? A ARG 185 NH1 
10 1 Y 1 A ARG 364 ? NH2 ? A ARG 185 NH2 
11 1 Y 1 A LYS 365 ? CG  ? A LYS 186 CG  
12 1 Y 1 A LYS 365 ? CD  ? A LYS 186 CD  
13 1 Y 1 A LYS 365 ? CE  ? A LYS 186 CE  
14 1 Y 1 A LYS 365 ? NZ  ? A LYS 186 NZ  
15 1 Y 1 A ARG 370 ? CG  ? A ARG 191 CG  
16 1 Y 1 A ARG 370 ? CD  ? A ARG 191 CD  
17 1 Y 1 A ARG 370 ? NE  ? A ARG 191 NE  
18 1 Y 1 A ARG 370 ? CZ  ? A ARG 191 CZ  
19 1 Y 1 A ARG 370 ? NH1 ? A ARG 191 NH1 
20 1 Y 1 A ARG 370 ? NH2 ? A ARG 191 NH2 
21 1 Y 1 A LYS 376 ? CG  ? A LYS 197 CG  
22 1 Y 1 A LYS 376 ? CD  ? A LYS 197 CD  
23 1 Y 1 A LYS 376 ? CE  ? A LYS 197 CE  
24 1 Y 1 A LYS 376 ? NZ  ? A LYS 197 NZ  
25 1 Y 1 A LYS 399 ? CG  ? A LYS 220 CG  
26 1 Y 1 A LYS 399 ? CD  ? A LYS 220 CD  
27 1 Y 1 A LYS 399 ? CE  ? A LYS 220 CE  
28 1 Y 1 A LYS 399 ? NZ  ? A LYS 220 NZ  
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? BUSTER ? ? ? 2.10.4 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .      2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .      3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .      4 
# 
_cell.angle_alpha                  90 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   105.57 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9GFI 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     87.51 
_cell.length_a_esd                 ? 
_cell.length_b                     62.06 
_cell.length_b_esd                 ? 
_cell.length_c                     49.35 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9GFI 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                5 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'C 1 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9GFI 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.30 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          46.60 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    'PEG 3350 20%, 0.2M NaSCN' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            290 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 9M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2021-11-20 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.98 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SOLEIL BEAMLINE PROXIMA 2' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.98 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   'PROXIMA 2' 
_diffrn_source.pdbx_synchrotron_site       SOLEIL 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9GFI 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.1 
_reflns.d_resolution_low                               42.12 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     14960 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.8 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                2.0 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          17.16 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.0873 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.10 
_reflns_shell.d_res_low                                     2.20 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1936 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  ? 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.3560 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            4.2203 
_refine.aniso_B[1][2]                            0 
_refine.aniso_B[1][3]                            0.9335 
_refine.aniso_B[2][2]                            -15.1462 
_refine.aniso_B[2][3]                            0 
_refine.aniso_B[3][3]                            10.926 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               52.16 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.936 
_refine.correlation_coeff_Fo_to_Fc_free          0.916 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9GFI 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.1 
_refine.ls_d_res_low                             42.15 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     14960 
_refine.ls_number_reflns_R_free                  1497 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.8 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2281 
_refine.ls_R_factor_R_free                       0.2716 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2233 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   0.208 
_refine.pdbx_overall_SU_R_free_Blow_DPI          0.204 
_refine.pdbx_overall_SU_R_Blow_DPI               0.246 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            ? 
_refine.overall_SU_R_Cruickshank_DPI             0.252 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_analyze.entry_id                        9GFI 
_refine_analyze.pdbx_refine_id                  'X-RAY DIFFRACTION' 
_refine_analyze.Luzzati_coordinate_error_free   ? 
_refine_analyze.Luzzati_coordinate_error_obs    0.32 
_refine_analyze.Luzzati_d_res_low_free          ? 
_refine_analyze.Luzzati_d_res_low_obs           ? 
_refine_analyze.Luzzati_sigma_a_free            ? 
_refine_analyze.Luzzati_sigma_a_free_details    ? 
_refine_analyze.Luzzati_sigma_a_obs             ? 
_refine_analyze.Luzzati_sigma_a_obs_details     ? 
_refine_analyze.number_disordered_residues      ? 
_refine_analyze.occupancy_sum_hydrogen          ? 
_refine_analyze.occupancy_sum_non_hydrogen      ? 
_refine_analyze.RG_d_res_high                   ? 
_refine_analyze.RG_d_res_low                    ? 
_refine_analyze.RG_free                         ? 
_refine_analyze.RG_work                         ? 
_refine_analyze.RG_free_work_ratio              ? 
_refine_analyze.pdbx_Luzzati_d_res_high_obs     ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.1 
_refine_hist.d_res_low                        42.15 
_refine_hist.number_atoms_solvent             55 
_refine_hist.number_atoms_total               2008 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        1834 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         119 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.008 ? 1990 ? t_bond_d                  2  HARMONIC     
'X-RAY DIFFRACTION' ? 0.94  ? 2701 ? t_angle_deg               2  HARMONIC     
'X-RAY DIFFRACTION' ? ?     ? 741  ? t_dihedral_angle_d        2  SINUSOIDAL   
'X-RAY DIFFRACTION' ? ?     ? 350  ? t_gen_planes              5  HARMONIC     
'X-RAY DIFFRACTION' ? ?     ? 1990 ? t_it                      10 HARMONIC     
'X-RAY DIFFRACTION' ? ?     ? 263  ? t_chiral_improper_torsion 5  SEMIHARMONIC 
'X-RAY DIFFRACTION' ? ?     ? 1683 ? t_ideal_dist_contact      4  SEMIHARMONIC 
'X-RAY DIFFRACTION' ? 2.67  ? ?    ? t_omega_torsion           ?  ?            
'X-RAY DIFFRACTION' ? 18.13 ? ?    ? t_other_torsion           ?  ?            
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.d_res_high                       2.1 
_refine_ls_shell.d_res_low                        2.11 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.number_reflns_obs                300 
_refine_ls_shell.number_reflns_R_free             30 
_refine_ls_shell.number_reflns_R_work             ? 
_refine_ls_shell.percent_reflns_obs               97.64 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     0.3815 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.R_factor_R_work                  0.3747 
_refine_ls_shell.redundancy_reflns_all            ? 
_refine_ls_shell.redundancy_reflns_obs            ? 
_refine_ls_shell.wR_factor_all                    ? 
_refine_ls_shell.wR_factor_obs                    ? 
_refine_ls_shell.wR_factor_R_free                 ? 
_refine_ls_shell.wR_factor_R_work                 ? 
_refine_ls_shell.pdbx_R_complete                  ? 
_refine_ls_shell.pdbx_total_number_of_bins_used   ? 
_refine_ls_shell.pdbx_phase_error                 ? 
_refine_ls_shell.pdbx_fsc_work                    ? 
_refine_ls_shell.pdbx_fsc_free                    ? 
_refine_ls_shell.R_factor_R_free                  0.449 
# 
_struct.entry_id                     9GFI 
_struct.title                        'hRAR alpha LBD-AM580 complex with staple peptide' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9GFI 
_struct_keywords.text            'RAR complex, staple peptide, TRANSCRIPTION' 
_struct_keywords.pdbx_keywords   TRANSCRIPTION 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP RARA_HUMAN P10276 ? 1 
;LTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQIT
LLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDR
QDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLE
;
180 
2 PDB 9GFI       9GFI   ? 2 ? 1   
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9GFI A 1 ? 236 ? P10276 180 ? 415 ? 180 415 
2 2 9GFI B 1 ? 10  ? 9GFI   1   ? 10  ? 1   10  
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'NMR Distance Restraints' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 THR A 2   ? GLU A 18  ? THR A 181 GLU A 197 1 ? 17 
HELX_P HELX_P2  AA2 ALA A 22  ? LEU A 26  ? ALA A 201 LEU A 205 5 ? 5  
HELX_P HELX_P3  AA3 ASP A 42  ? GLN A 66  ? ASP A 221 GLN A 245 1 ? 25 
HELX_P HELX_P4  AA4 GLY A 69  ? LEU A 73  ? GLY A 248 LEU A 252 5 ? 5  
HELX_P HELX_P5  AA5 THR A 74  ? ARG A 97  ? THR A 253 ARG A 276 1 ? 24 
HELX_P HELX_P6  AA6 ARG A 115 ? GLY A 122 ? ARG A 294 GLY A 301 1 ? 8  
HELX_P HELX_P7  AA7 PHE A 123 ? PRO A 125 ? PHE A 302 PRO A 304 5 ? 3  
HELX_P HELX_P8  AA8 LEU A 126 ? LEU A 138 ? LEU A 305 LEU A 317 1 ? 13 
HELX_P HELX_P9  AA9 PRO A 139 ? GLU A 141 ? PRO A 318 GLU A 320 5 ? 3  
HELX_P HELX_P10 AB1 ASP A 143 ? ILE A 156 ? ASP A 322 ILE A 335 1 ? 14 
HELX_P HELX_P11 AB2 GLN A 165 ? ARG A 188 ? GLN A 344 ARG A 367 1 ? 24 
HELX_P HELX_P12 AB3 HIS A 193 ? ILE A 223 ? HIS A 372 ILE A 402 1 ? 31 
HELX_P HELX_P13 AB4 PRO A 228 ? GLU A 236 ? PRO A 407 GLU A 415 1 ? 9  
HELX_P HELX_P14 AB5 LYS B 2   ? HRG B 9   ? LYS B 2   HRG B 9   1 ? 8  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
covale1 covale both ? B LEU 4 C  ? ? ? 1_555 B NLE   5  N   ? ? B LEU 4 B NLE   5  1_555 ? ? ? ? ? ? ? 1.371 ? ? 
covale2 covale both ? B NLE 5 C  ? ? ? 1_555 B ARG   6  N   ? ? B NLE 5 B ARG   6  1_555 ? ? ? ? ? ? ? 1.352 ? ? 
covale3 covale none ? B NLE 5 CE ? ? ? 1_555 B HRG   9  NH2 ? ? B NLE 5 B HRG   9  1_555 ? ? ? ? ? ? ? 1.466 ? ? 
covale4 covale both ? B LEU 8 C  ? ? ? 1_555 B HRG   9  N   ? ? B LEU 8 B HRG   9  1_555 ? ? ? ? ? ? ? 1.348 ? ? 
covale5 covale both ? B HRG 9 C  ? ? ? 1_555 B A1IM7 10 N   ? ? B HRG 9 B A1IM7 10 1_555 ? ? ? ? ? ? ? 1.351 ? ? 
# 
_struct_conn_type.id          covale 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 NLE   B 5  ? .   . . . NLE   B 5  ? 1_555 .   . . . .     .  .   LEU 1 NLE   Norleucine      'Named protein modification' 
2 A1IM7 B 10 ? .   . . . A1IM7 B 10 ? 1_555 .   . . . .     .  .   GLU 1 A1IM7 Methylamination 'Named protein modification' 
3 HRG   B 9  ? .   . . . HRG   B 9  ? 1_555 .   . . . .     .  .   ?   1 HRG   None            'Non-standard residue'       
4 NLE   B 5  ? HRG B 9 ? NLE   B 5  ? 1_555 HRG B 9 ? 1_555 CE NH2 .   . .     None            'Non-standard linkage'       
# 
_struct_sheet.id               AA1 
_struct_sheet.type             ? 
_struct_sheet.number_strands   3 
_struct_sheet.details          ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 TYR A 98  ? THR A 99  ? TYR A 277 THR A 278 
AA1 2 THR A 104 ? THR A 106 ? THR A 283 THR A 285 
AA1 3 THR A 112 ? ASN A 114 ? THR A 291 ASN A 293 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N THR A 99  ? N THR A 278 O THR A 104 ? O THR A 283 
AA1 2 3 N MET A 105 ? N MET A 284 O LEU A 113 ? O LEU A 292 
# 
_pdbx_entry_details.entry_id                   9GFI 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_rmsd_bond.id 
_pdbx_validate_rmsd_bond.PDB_model_num 
_pdbx_validate_rmsd_bond.auth_atom_id_1 
_pdbx_validate_rmsd_bond.auth_asym_id_1 
_pdbx_validate_rmsd_bond.auth_comp_id_1 
_pdbx_validate_rmsd_bond.auth_seq_id_1 
_pdbx_validate_rmsd_bond.PDB_ins_code_1 
_pdbx_validate_rmsd_bond.label_alt_id_1 
_pdbx_validate_rmsd_bond.auth_atom_id_2 
_pdbx_validate_rmsd_bond.auth_asym_id_2 
_pdbx_validate_rmsd_bond.auth_comp_id_2 
_pdbx_validate_rmsd_bond.auth_seq_id_2 
_pdbx_validate_rmsd_bond.PDB_ins_code_2 
_pdbx_validate_rmsd_bond.label_alt_id_2 
_pdbx_validate_rmsd_bond.bond_value 
_pdbx_validate_rmsd_bond.bond_target_value 
_pdbx_validate_rmsd_bond.bond_deviation 
_pdbx_validate_rmsd_bond.bond_standard_deviation 
_pdbx_validate_rmsd_bond.linker_flag 
1 1 CG B HIS 1 ? ? CD2 B HIS 1 ? ? 1.491 1.354 0.137  0.009 N 
2 1 CG B HIS 1 ? ? ND1 B HIS 1 ? ? 1.274 1.369 -0.095 0.015 N 
3 1 N  B LEU 4 ? ? CA  B LEU 4 ? ? 1.315 1.459 -0.144 0.020 N 
4 1 N  B ARG 6 ? ? CA  B ARG 6 ? ? 1.331 1.459 -0.128 0.020 N 
# 
loop_
_pdbx_validate_rmsd_angle.id 
_pdbx_validate_rmsd_angle.PDB_model_num 
_pdbx_validate_rmsd_angle.auth_atom_id_1 
_pdbx_validate_rmsd_angle.auth_asym_id_1 
_pdbx_validate_rmsd_angle.auth_comp_id_1 
_pdbx_validate_rmsd_angle.auth_seq_id_1 
_pdbx_validate_rmsd_angle.PDB_ins_code_1 
_pdbx_validate_rmsd_angle.label_alt_id_1 
_pdbx_validate_rmsd_angle.auth_atom_id_2 
_pdbx_validate_rmsd_angle.auth_asym_id_2 
_pdbx_validate_rmsd_angle.auth_comp_id_2 
_pdbx_validate_rmsd_angle.auth_seq_id_2 
_pdbx_validate_rmsd_angle.PDB_ins_code_2 
_pdbx_validate_rmsd_angle.label_alt_id_2 
_pdbx_validate_rmsd_angle.auth_atom_id_3 
_pdbx_validate_rmsd_angle.auth_asym_id_3 
_pdbx_validate_rmsd_angle.auth_comp_id_3 
_pdbx_validate_rmsd_angle.auth_seq_id_3 
_pdbx_validate_rmsd_angle.PDB_ins_code_3 
_pdbx_validate_rmsd_angle.label_alt_id_3 
_pdbx_validate_rmsd_angle.angle_value 
_pdbx_validate_rmsd_angle.angle_target_value 
_pdbx_validate_rmsd_angle.angle_deviation 
_pdbx_validate_rmsd_angle.angle_standard_deviation 
_pdbx_validate_rmsd_angle.linker_flag 
1  1 N   B HIS 1 ? ? CA B HIS 1 ? ? CB  B HIS 1 ? ? 123.64 110.60 13.04  1.80 N 
2  1 CB  B HIS 1 ? ? CG B HIS 1 ? ? CD2 B HIS 1 ? ? 118.05 129.70 -11.65 1.60 N 
3  1 ND1 B HIS 1 ? ? CG B HIS 1 ? ? CD2 B HIS 1 ? ? 117.35 108.80 8.55   1.40 N 
4  1 N   B ILE 3 ? ? CA B ILE 3 ? ? C   B ILE 3 ? ? 127.70 111.00 16.70  2.70 N 
5  1 CB  B LEU 4 ? ? CG B LEU 4 ? ? CD1 B LEU 4 ? ? 124.92 111.00 13.92  1.70 N 
6  1 N   B LEU 4 ? ? CA B LEU 4 ? ? C   B LEU 4 ? ? 133.59 111.00 22.59  2.70 N 
7  1 CD  B ARG 6 ? ? NE B ARG 6 ? ? CZ  B ARG 6 ? ? 112.33 123.60 -11.27 1.40 N 
8  1 NE  B ARG 6 ? ? CZ B ARG 6 ? ? NH1 B ARG 6 ? ? 125.92 120.30 5.62   0.50 N 
9  1 N   B ARG 6 ? ? CA B ARG 6 ? ? C   B ARG 6 ? ? 129.32 111.00 18.32  2.70 N 
10 1 N   B LEU 7 ? ? CA B LEU 7 ? ? CB  B LEU 7 ? ? 125.25 110.40 14.85  2.00 N 
11 1 CB  B LEU 8 ? ? CG B LEU 8 ? ? CD2 B LEU 8 ? ? 122.81 111.00 11.81  1.70 N 
12 1 N   B LEU 8 ? ? CA B LEU 8 ? ? C   B LEU 8 ? ? 127.51 111.00 16.51  2.70 N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 SER A 213 ? ? 32.68   46.79   
2  1 ARG A 276 ? ? -104.95 43.01   
3  1 LYS B 2   ? ? 26.25   -107.23 
4  1 ILE B 3   ? ? -32.16  -77.14  
5  1 LEU B 4   ? ? 8.79    -88.62  
6  1 NLE B 5   ? ? -28.88  -59.99  
7  1 ARG B 6   ? ? -39.55  -79.13  
8  1 LEU B 7   ? ? 19.74   -89.97  
9  1 LEU B 8   ? ? -25.02  -92.85  
10 1 HRG B 9   ? ? -17.51  81.58   
# 
loop_
_pdbx_validate_peptide_omega.id 
_pdbx_validate_peptide_omega.PDB_model_num 
_pdbx_validate_peptide_omega.auth_comp_id_1 
_pdbx_validate_peptide_omega.auth_asym_id_1 
_pdbx_validate_peptide_omega.auth_seq_id_1 
_pdbx_validate_peptide_omega.PDB_ins_code_1 
_pdbx_validate_peptide_omega.label_alt_id_1 
_pdbx_validate_peptide_omega.auth_comp_id_2 
_pdbx_validate_peptide_omega.auth_asym_id_2 
_pdbx_validate_peptide_omega.auth_seq_id_2 
_pdbx_validate_peptide_omega.PDB_ins_code_2 
_pdbx_validate_peptide_omega.label_alt_id_2 
_pdbx_validate_peptide_omega.omega 
1 1 HIS B 1 ? ? LYS   B 2  ? ? 133.47  
2 1 ILE B 3 ? ? LEU   B 4  ? ? 133.03  
3 1 ARG B 6 ? ? LEU   B 7  ? ? 118.57  
4 1 LEU B 8 ? ? HRG   B 9  ? ? 142.29  
5 1 HRG B 9 ? ? A1IM7 B 10 ? ? -133.16 
# 
loop_
_pdbx_validate_chiral.id 
_pdbx_validate_chiral.PDB_model_num 
_pdbx_validate_chiral.auth_atom_id 
_pdbx_validate_chiral.label_alt_id 
_pdbx_validate_chiral.auth_asym_id 
_pdbx_validate_chiral.auth_comp_id 
_pdbx_validate_chiral.auth_seq_id 
_pdbx_validate_chiral.PDB_ins_code 
_pdbx_validate_chiral.details 
_pdbx_validate_chiral.omega 
1  1 CA ? B HIS   1  ? PLANAR . 
2  1 CA ? B LYS   2  ? PLANAR . 
3  1 CA ? B ILE   3  ? PLANAR . 
4  1 CB ? B ILE   3  ? PLANAR . 
5  1 CA ? B LEU   4  ? PLANAR . 
6  1 CA ? B NLE   5  ? PLANAR . 
7  1 CA ? B ARG   6  ? PLANAR . 
8  1 CA ? B LEU   7  ? PLANAR . 
9  1 CA ? B LEU   8  ? PLANAR . 
10 1 CA ? B HRG   9  ? PLANAR . 
11 1 CA ? B A1IM7 10 ? PLANAR . 
# 
_pdbx_validate_planes.id              1 
_pdbx_validate_planes.PDB_model_num   1 
_pdbx_validate_planes.auth_comp_id    ARG 
_pdbx_validate_planes.auth_asym_id    B 
_pdbx_validate_planes.auth_seq_id     6 
_pdbx_validate_planes.PDB_ins_code    ? 
_pdbx_validate_planes.label_alt_id    ? 
_pdbx_validate_planes.rmsd            0.311 
_pdbx_validate_planes.type            'SIDE CHAIN' 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1IM7 C17    C N N 1   
A1IM7 N      N N N 2   
A1IM7 CA     C N S 3   
A1IM7 C      C N N 4   
A1IM7 O      O N N 5   
A1IM7 CB     C N N 6   
A1IM7 CG     C N N 7   
A1IM7 CD     C N N 8   
A1IM7 OE1    O N N 9   
A1IM7 OE2    O N N 10  
A1IM7 N12    N N N 11  
A1IM7 H1     H N N 12  
A1IM7 H6     H N N 13  
A1IM7 H3     H N N 14  
A1IM7 H      H N N 15  
A1IM7 H2     H N N 16  
A1IM7 HA     H N N 17  
A1IM7 HB2    H N N 18  
A1IM7 HB3    H N N 19  
A1IM7 HG2    H N N 20  
A1IM7 HG3    H N N 21  
A1IM7 HE2    H N N 22  
A1IM7 H13    H N N 23  
ALA   N      N N N 24  
ALA   CA     C N S 25  
ALA   C      C N N 26  
ALA   O      O N N 27  
ALA   CB     C N N 28  
ALA   OXT    O N N 29  
ALA   H      H N N 30  
ALA   H2     H N N 31  
ALA   HA     H N N 32  
ALA   HB1    H N N 33  
ALA   HB2    H N N 34  
ALA   HB3    H N N 35  
ALA   HXT    H N N 36  
ARG   N      N N N 37  
ARG   CA     C N S 38  
ARG   C      C N N 39  
ARG   O      O N N 40  
ARG   CB     C N N 41  
ARG   CG     C N N 42  
ARG   CD     C N N 43  
ARG   NE     N N N 44  
ARG   CZ     C N N 45  
ARG   NH1    N N N 46  
ARG   NH2    N N N 47  
ARG   OXT    O N N 48  
ARG   H      H N N 49  
ARG   H2     H N N 50  
ARG   HA     H N N 51  
ARG   HB2    H N N 52  
ARG   HB3    H N N 53  
ARG   HG2    H N N 54  
ARG   HG3    H N N 55  
ARG   HD2    H N N 56  
ARG   HD3    H N N 57  
ARG   HE     H N N 58  
ARG   HH11   H N N 59  
ARG   HH12   H N N 60  
ARG   HH21   H N N 61  
ARG   HH22   H N N 62  
ARG   HXT    H N N 63  
ASN   N      N N N 64  
ASN   CA     C N S 65  
ASN   C      C N N 66  
ASN   O      O N N 67  
ASN   CB     C N N 68  
ASN   CG     C N N 69  
ASN   OD1    O N N 70  
ASN   ND2    N N N 71  
ASN   OXT    O N N 72  
ASN   H      H N N 73  
ASN   H2     H N N 74  
ASN   HA     H N N 75  
ASN   HB2    H N N 76  
ASN   HB3    H N N 77  
ASN   HD21   H N N 78  
ASN   HD22   H N N 79  
ASN   HXT    H N N 80  
ASP   N      N N N 81  
ASP   CA     C N S 82  
ASP   C      C N N 83  
ASP   O      O N N 84  
ASP   CB     C N N 85  
ASP   CG     C N N 86  
ASP   OD1    O N N 87  
ASP   OD2    O N N 88  
ASP   OXT    O N N 89  
ASP   H      H N N 90  
ASP   H2     H N N 91  
ASP   HA     H N N 92  
ASP   HB2    H N N 93  
ASP   HB3    H N N 94  
ASP   HD2    H N N 95  
ASP   HXT    H N N 96  
CYS   N      N N N 97  
CYS   CA     C N R 98  
CYS   C      C N N 99  
CYS   O      O N N 100 
CYS   CB     C N N 101 
CYS   SG     S N N 102 
CYS   OXT    O N N 103 
CYS   H      H N N 104 
CYS   H2     H N N 105 
CYS   HA     H N N 106 
CYS   HB2    H N N 107 
CYS   HB3    H N N 108 
CYS   HG     H N N 109 
CYS   HXT    H N N 110 
EQN   CAA    C N N 111 
EQN   CAB    C N N 112 
EQN   CAC    C N N 113 
EQN   CAD    C N N 114 
EQN   OAE    O N N 115 
EQN   OAF    O N N 116 
EQN   OAG    O N N 117 
EQN   CAH    C Y N 118 
EQN   CAI    C Y N 119 
EQN   CAJ    C Y N 120 
EQN   CAK    C Y N 121 
EQN   CAL    C Y N 122 
EQN   CAM    C Y N 123 
EQN   CAN    C Y N 124 
EQN   CAO    C N N 125 
EQN   CAP    C N N 126 
EQN   NAQ    N N N 127 
EQN   CAR    C N N 128 
EQN   CAS    C N N 129 
EQN   CAT    C Y N 130 
EQN   CAU    C Y N 131 
EQN   CAV    C Y N 132 
EQN   CAW    C Y N 133 
EQN   CAX    C Y N 134 
EQN   CAY    C N N 135 
EQN   CAZ    C N N 136 
EQN   HAA    H N N 137 
EQN   HAAA   H N N 138 
EQN   HAAB   H N N 139 
EQN   HAB    H N N 140 
EQN   HABA   H N N 141 
EQN   HABB   H N N 142 
EQN   HAC    H N N 143 
EQN   HACA   H N N 144 
EQN   HACB   H N N 145 
EQN   HAD    H N N 146 
EQN   HADA   H N N 147 
EQN   HADB   H N N 148 
EQN   HAH    H N N 149 
EQN   HAI    H N N 150 
EQN   HAJ    H N N 151 
EQN   HAK    H N N 152 
EQN   HAL    H N N 153 
EQN   HAM    H N N 154 
EQN   HAN    H N N 155 
EQN   HAO    H N N 156 
EQN   HAOA   H N N 157 
EQN   HAP    H N N 158 
EQN   HAPA   H N N 159 
EQN   HNAQ   H N N 160 
EQN   H25    H N N 161 
GLN   N      N N N 162 
GLN   CA     C N S 163 
GLN   C      C N N 164 
GLN   O      O N N 165 
GLN   CB     C N N 166 
GLN   CG     C N N 167 
GLN   CD     C N N 168 
GLN   OE1    O N N 169 
GLN   NE2    N N N 170 
GLN   OXT    O N N 171 
GLN   H      H N N 172 
GLN   H2     H N N 173 
GLN   HA     H N N 174 
GLN   HB2    H N N 175 
GLN   HB3    H N N 176 
GLN   HG2    H N N 177 
GLN   HG3    H N N 178 
GLN   HE21   H N N 179 
GLN   HE22   H N N 180 
GLN   HXT    H N N 181 
GLU   N      N N N 182 
GLU   CA     C N S 183 
GLU   C      C N N 184 
GLU   O      O N N 185 
GLU   CB     C N N 186 
GLU   CG     C N N 187 
GLU   CD     C N N 188 
GLU   OE1    O N N 189 
GLU   OE2    O N N 190 
GLU   OXT    O N N 191 
GLU   H      H N N 192 
GLU   H2     H N N 193 
GLU   HA     H N N 194 
GLU   HB2    H N N 195 
GLU   HB3    H N N 196 
GLU   HG2    H N N 197 
GLU   HG3    H N N 198 
GLU   HE2    H N N 199 
GLU   HXT    H N N 200 
GLY   N      N N N 201 
GLY   CA     C N N 202 
GLY   C      C N N 203 
GLY   O      O N N 204 
GLY   OXT    O N N 205 
GLY   H      H N N 206 
GLY   H2     H N N 207 
GLY   HA2    H N N 208 
GLY   HA3    H N N 209 
GLY   HXT    H N N 210 
HIS   N      N N N 211 
HIS   CA     C N S 212 
HIS   C      C N N 213 
HIS   O      O N N 214 
HIS   CB     C N N 215 
HIS   CG     C Y N 216 
HIS   ND1    N Y N 217 
HIS   CD2    C Y N 218 
HIS   CE1    C Y N 219 
HIS   NE2    N Y N 220 
HIS   OXT    O N N 221 
HIS   H      H N N 222 
HIS   H2     H N N 223 
HIS   HA     H N N 224 
HIS   HB2    H N N 225 
HIS   HB3    H N N 226 
HIS   HD1    H N N 227 
HIS   HD2    H N N 228 
HIS   HE1    H N N 229 
HIS   HE2    H N N 230 
HIS   HXT    H N N 231 
HOH   O      O N N 232 
HOH   H1     H N N 233 
HOH   H2     H N N 234 
HRG   N      N N N 235 
HRG   CA     C N S 236 
HRG   CB     C N N 237 
HRG   CG     C N N 238 
HRG   "CG'"  C N N 239 
HRG   CD     C N N 240 
HRG   NE     N N N 241 
HRG   CZ     C N N 242 
HRG   NH1    N N N 243 
HRG   NH2    N N N 244 
HRG   C      C N N 245 
HRG   O      O N N 246 
HRG   OXT    O N N 247 
HRG   H      H N N 248 
HRG   H2     H N N 249 
HRG   HA     H N N 250 
HRG   HB1    H N N 251 
HRG   HB2    H N N 252 
HRG   HG1    H N N 253 
HRG   HG2    H N N 254 
HRG   "HG'1" H N N 255 
HRG   "HG'2" H N N 256 
HRG   HD1    H N N 257 
HRG   HD2    H N N 258 
HRG   HNE    H N N 259 
HRG   HN1    H N N 260 
HRG   HN21   H N N 261 
HRG   HN22   H N N 262 
HRG   HXT    H N N 263 
ILE   N      N N N 264 
ILE   CA     C N S 265 
ILE   C      C N N 266 
ILE   O      O N N 267 
ILE   CB     C N S 268 
ILE   CG1    C N N 269 
ILE   CG2    C N N 270 
ILE   CD1    C N N 271 
ILE   OXT    O N N 272 
ILE   H      H N N 273 
ILE   H2     H N N 274 
ILE   HA     H N N 275 
ILE   HB     H N N 276 
ILE   HG12   H N N 277 
ILE   HG13   H N N 278 
ILE   HG21   H N N 279 
ILE   HG22   H N N 280 
ILE   HG23   H N N 281 
ILE   HD11   H N N 282 
ILE   HD12   H N N 283 
ILE   HD13   H N N 284 
ILE   HXT    H N N 285 
LEU   N      N N N 286 
LEU   CA     C N S 287 
LEU   C      C N N 288 
LEU   O      O N N 289 
LEU   CB     C N N 290 
LEU   CG     C N N 291 
LEU   CD1    C N N 292 
LEU   CD2    C N N 293 
LEU   OXT    O N N 294 
LEU   H      H N N 295 
LEU   H2     H N N 296 
LEU   HA     H N N 297 
LEU   HB2    H N N 298 
LEU   HB3    H N N 299 
LEU   HG     H N N 300 
LEU   HD11   H N N 301 
LEU   HD12   H N N 302 
LEU   HD13   H N N 303 
LEU   HD21   H N N 304 
LEU   HD22   H N N 305 
LEU   HD23   H N N 306 
LEU   HXT    H N N 307 
LYS   N      N N N 308 
LYS   CA     C N S 309 
LYS   C      C N N 310 
LYS   O      O N N 311 
LYS   CB     C N N 312 
LYS   CG     C N N 313 
LYS   CD     C N N 314 
LYS   CE     C N N 315 
LYS   NZ     N N N 316 
LYS   OXT    O N N 317 
LYS   H      H N N 318 
LYS   H2     H N N 319 
LYS   HA     H N N 320 
LYS   HB2    H N N 321 
LYS   HB3    H N N 322 
LYS   HG2    H N N 323 
LYS   HG3    H N N 324 
LYS   HD2    H N N 325 
LYS   HD3    H N N 326 
LYS   HE2    H N N 327 
LYS   HE3    H N N 328 
LYS   HZ1    H N N 329 
LYS   HZ2    H N N 330 
LYS   HZ3    H N N 331 
LYS   HXT    H N N 332 
MET   N      N N N 333 
MET   CA     C N S 334 
MET   C      C N N 335 
MET   O      O N N 336 
MET   CB     C N N 337 
MET   CG     C N N 338 
MET   SD     S N N 339 
MET   CE     C N N 340 
MET   OXT    O N N 341 
MET   H      H N N 342 
MET   H2     H N N 343 
MET   HA     H N N 344 
MET   HB2    H N N 345 
MET   HB3    H N N 346 
MET   HG2    H N N 347 
MET   HG3    H N N 348 
MET   HE1    H N N 349 
MET   HE2    H N N 350 
MET   HE3    H N N 351 
MET   HXT    H N N 352 
NLE   N      N N N 353 
NLE   CA     C N S 354 
NLE   C      C N N 355 
NLE   O      O N N 356 
NLE   OXT    O N N 357 
NLE   CB     C N N 358 
NLE   CG     C N N 359 
NLE   CD     C N N 360 
NLE   CE     C N N 361 
NLE   H      H N N 362 
NLE   H2     H N N 363 
NLE   HA     H N N 364 
NLE   HXT    H N N 365 
NLE   HB2    H N N 366 
NLE   HB3    H N N 367 
NLE   HG2    H N N 368 
NLE   HG3    H N N 369 
NLE   HD2    H N N 370 
NLE   HD3    H N N 371 
NLE   HE1    H N N 372 
NLE   HE2    H N N 373 
NLE   HE3    H N N 374 
PHE   N      N N N 375 
PHE   CA     C N S 376 
PHE   C      C N N 377 
PHE   O      O N N 378 
PHE   CB     C N N 379 
PHE   CG     C Y N 380 
PHE   CD1    C Y N 381 
PHE   CD2    C Y N 382 
PHE   CE1    C Y N 383 
PHE   CE2    C Y N 384 
PHE   CZ     C Y N 385 
PHE   OXT    O N N 386 
PHE   H      H N N 387 
PHE   H2     H N N 388 
PHE   HA     H N N 389 
PHE   HB2    H N N 390 
PHE   HB3    H N N 391 
PHE   HD1    H N N 392 
PHE   HD2    H N N 393 
PHE   HE1    H N N 394 
PHE   HE2    H N N 395 
PHE   HZ     H N N 396 
PHE   HXT    H N N 397 
PRO   N      N N N 398 
PRO   CA     C N S 399 
PRO   C      C N N 400 
PRO   O      O N N 401 
PRO   CB     C N N 402 
PRO   CG     C N N 403 
PRO   CD     C N N 404 
PRO   OXT    O N N 405 
PRO   H      H N N 406 
PRO   HA     H N N 407 
PRO   HB2    H N N 408 
PRO   HB3    H N N 409 
PRO   HG2    H N N 410 
PRO   HG3    H N N 411 
PRO   HD2    H N N 412 
PRO   HD3    H N N 413 
PRO   HXT    H N N 414 
SER   N      N N N 415 
SER   CA     C N S 416 
SER   C      C N N 417 
SER   O      O N N 418 
SER   CB     C N N 419 
SER   OG     O N N 420 
SER   OXT    O N N 421 
SER   H      H N N 422 
SER   H2     H N N 423 
SER   HA     H N N 424 
SER   HB2    H N N 425 
SER   HB3    H N N 426 
SER   HG     H N N 427 
SER   HXT    H N N 428 
THR   N      N N N 429 
THR   CA     C N S 430 
THR   C      C N N 431 
THR   O      O N N 432 
THR   CB     C N R 433 
THR   OG1    O N N 434 
THR   CG2    C N N 435 
THR   OXT    O N N 436 
THR   H      H N N 437 
THR   H2     H N N 438 
THR   HA     H N N 439 
THR   HB     H N N 440 
THR   HG1    H N N 441 
THR   HG21   H N N 442 
THR   HG22   H N N 443 
THR   HG23   H N N 444 
THR   HXT    H N N 445 
TRP   N      N N N 446 
TRP   CA     C N S 447 
TRP   C      C N N 448 
TRP   O      O N N 449 
TRP   CB     C N N 450 
TRP   CG     C Y N 451 
TRP   CD1    C Y N 452 
TRP   CD2    C Y N 453 
TRP   NE1    N Y N 454 
TRP   CE2    C Y N 455 
TRP   CE3    C Y N 456 
TRP   CZ2    C Y N 457 
TRP   CZ3    C Y N 458 
TRP   CH2    C Y N 459 
TRP   OXT    O N N 460 
TRP   H      H N N 461 
TRP   H2     H N N 462 
TRP   HA     H N N 463 
TRP   HB2    H N N 464 
TRP   HB3    H N N 465 
TRP   HD1    H N N 466 
TRP   HE1    H N N 467 
TRP   HE3    H N N 468 
TRP   HZ2    H N N 469 
TRP   HZ3    H N N 470 
TRP   HH2    H N N 471 
TRP   HXT    H N N 472 
TYR   N      N N N 473 
TYR   CA     C N S 474 
TYR   C      C N N 475 
TYR   O      O N N 476 
TYR   CB     C N N 477 
TYR   CG     C Y N 478 
TYR   CD1    C Y N 479 
TYR   CD2    C Y N 480 
TYR   CE1    C Y N 481 
TYR   CE2    C Y N 482 
TYR   CZ     C Y N 483 
TYR   OH     O N N 484 
TYR   OXT    O N N 485 
TYR   H      H N N 486 
TYR   H2     H N N 487 
TYR   HA     H N N 488 
TYR   HB2    H N N 489 
TYR   HB3    H N N 490 
TYR   HD1    H N N 491 
TYR   HD2    H N N 492 
TYR   HE1    H N N 493 
TYR   HE2    H N N 494 
TYR   HH     H N N 495 
TYR   HXT    H N N 496 
VAL   N      N N N 497 
VAL   CA     C N S 498 
VAL   C      C N N 499 
VAL   O      O N N 500 
VAL   CB     C N N 501 
VAL   CG1    C N N 502 
VAL   CG2    C N N 503 
VAL   OXT    O N N 504 
VAL   H      H N N 505 
VAL   H2     H N N 506 
VAL   HA     H N N 507 
VAL   HB     H N N 508 
VAL   HG11   H N N 509 
VAL   HG12   H N N 510 
VAL   HG13   H N N 511 
VAL   HG21   H N N 512 
VAL   HG22   H N N 513 
VAL   HG23   H N N 514 
VAL   HXT    H N N 515 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1IM7 N     CA     sing N N 1   
A1IM7 N12   C17    sing N N 2   
A1IM7 N12   C      sing N N 3   
A1IM7 CB    CA     sing N N 4   
A1IM7 CB    CG     sing N N 5   
A1IM7 CA    C      sing N N 6   
A1IM7 C     O      doub N N 7   
A1IM7 CG    CD     sing N N 8   
A1IM7 OE1   CD     doub N N 9   
A1IM7 CD    OE2    sing N N 10  
A1IM7 C17   H1     sing N N 11  
A1IM7 C17   H6     sing N N 12  
A1IM7 C17   H3     sing N N 13  
A1IM7 N     H      sing N N 14  
A1IM7 N     H2     sing N N 15  
A1IM7 CA    HA     sing N N 16  
A1IM7 CB    HB2    sing N N 17  
A1IM7 CB    HB3    sing N N 18  
A1IM7 CG    HG2    sing N N 19  
A1IM7 CG    HG3    sing N N 20  
A1IM7 OE2   HE2    sing N N 21  
A1IM7 N12   H13    sing N N 22  
ALA   N     CA     sing N N 23  
ALA   N     H      sing N N 24  
ALA   N     H2     sing N N 25  
ALA   CA    C      sing N N 26  
ALA   CA    CB     sing N N 27  
ALA   CA    HA     sing N N 28  
ALA   C     O      doub N N 29  
ALA   C     OXT    sing N N 30  
ALA   CB    HB1    sing N N 31  
ALA   CB    HB2    sing N N 32  
ALA   CB    HB3    sing N N 33  
ALA   OXT   HXT    sing N N 34  
ARG   N     CA     sing N N 35  
ARG   N     H      sing N N 36  
ARG   N     H2     sing N N 37  
ARG   CA    C      sing N N 38  
ARG   CA    CB     sing N N 39  
ARG   CA    HA     sing N N 40  
ARG   C     O      doub N N 41  
ARG   C     OXT    sing N N 42  
ARG   CB    CG     sing N N 43  
ARG   CB    HB2    sing N N 44  
ARG   CB    HB3    sing N N 45  
ARG   CG    CD     sing N N 46  
ARG   CG    HG2    sing N N 47  
ARG   CG    HG3    sing N N 48  
ARG   CD    NE     sing N N 49  
ARG   CD    HD2    sing N N 50  
ARG   CD    HD3    sing N N 51  
ARG   NE    CZ     sing N N 52  
ARG   NE    HE     sing N N 53  
ARG   CZ    NH1    sing N N 54  
ARG   CZ    NH2    doub N N 55  
ARG   NH1   HH11   sing N N 56  
ARG   NH1   HH12   sing N N 57  
ARG   NH2   HH21   sing N N 58  
ARG   NH2   HH22   sing N N 59  
ARG   OXT   HXT    sing N N 60  
ASN   N     CA     sing N N 61  
ASN   N     H      sing N N 62  
ASN   N     H2     sing N N 63  
ASN   CA    C      sing N N 64  
ASN   CA    CB     sing N N 65  
ASN   CA    HA     sing N N 66  
ASN   C     O      doub N N 67  
ASN   C     OXT    sing N N 68  
ASN   CB    CG     sing N N 69  
ASN   CB    HB2    sing N N 70  
ASN   CB    HB3    sing N N 71  
ASN   CG    OD1    doub N N 72  
ASN   CG    ND2    sing N N 73  
ASN   ND2   HD21   sing N N 74  
ASN   ND2   HD22   sing N N 75  
ASN   OXT   HXT    sing N N 76  
ASP   N     CA     sing N N 77  
ASP   N     H      sing N N 78  
ASP   N     H2     sing N N 79  
ASP   CA    C      sing N N 80  
ASP   CA    CB     sing N N 81  
ASP   CA    HA     sing N N 82  
ASP   C     O      doub N N 83  
ASP   C     OXT    sing N N 84  
ASP   CB    CG     sing N N 85  
ASP   CB    HB2    sing N N 86  
ASP   CB    HB3    sing N N 87  
ASP   CG    OD1    doub N N 88  
ASP   CG    OD2    sing N N 89  
ASP   OD2   HD2    sing N N 90  
ASP   OXT   HXT    sing N N 91  
CYS   N     CA     sing N N 92  
CYS   N     H      sing N N 93  
CYS   N     H2     sing N N 94  
CYS   CA    C      sing N N 95  
CYS   CA    CB     sing N N 96  
CYS   CA    HA     sing N N 97  
CYS   C     O      doub N N 98  
CYS   C     OXT    sing N N 99  
CYS   CB    SG     sing N N 100 
CYS   CB    HB2    sing N N 101 
CYS   CB    HB3    sing N N 102 
CYS   SG    HG     sing N N 103 
CYS   OXT   HXT    sing N N 104 
EQN   CAA   CAY    sing N N 105 
EQN   CAA   HAA    sing N N 106 
EQN   CAA   HAAA   sing N N 107 
EQN   CAA   HAAB   sing N N 108 
EQN   CAB   CAY    sing N N 109 
EQN   CAB   HAB    sing N N 110 
EQN   CAB   HABA   sing N N 111 
EQN   CAB   HABB   sing N N 112 
EQN   CAC   CAZ    sing N N 113 
EQN   CAC   HAC    sing N N 114 
EQN   CAC   HACA   sing N N 115 
EQN   CAC   HACB   sing N N 116 
EQN   CAD   CAZ    sing N N 117 
EQN   CAD   HAD    sing N N 118 
EQN   CAD   HADA   sing N N 119 
EQN   CAD   HADB   sing N N 120 
EQN   OAE   CAR    doub N N 121 
EQN   OAF   CAS    doub N N 122 
EQN   OAG   CAR    sing N N 123 
EQN   CAH   CAJ    doub Y N 124 
EQN   CAH   CAT    sing Y N 125 
EQN   CAH   HAH    sing N N 126 
EQN   CAI   CAK    sing Y N 127 
EQN   CAI   CAT    doub Y N 128 
EQN   CAI   HAI    sing N N 129 
EQN   CAJ   CAU    sing Y N 130 
EQN   CAJ   HAJ    sing N N 131 
EQN   CAK   CAU    doub Y N 132 
EQN   CAK   HAK    sing N N 133 
EQN   CAL   CAM    doub Y N 134 
EQN   CAL   CAV    sing Y N 135 
EQN   CAL   HAL    sing N N 136 
EQN   CAM   CAW    sing Y N 137 
EQN   CAM   HAM    sing N N 138 
EQN   CAN   CAV    doub Y N 139 
EQN   CAN   CAX    sing Y N 140 
EQN   CAN   HAN    sing N N 141 
EQN   CAO   CAP    sing N N 142 
EQN   CAO   CAY    sing N N 143 
EQN   CAO   HAO    sing N N 144 
EQN   CAO   HAOA   sing N N 145 
EQN   CAP   CAZ    sing N N 146 
EQN   CAP   HAP    sing N N 147 
EQN   CAP   HAPA   sing N N 148 
EQN   NAQ   CAS    sing N N 149 
EQN   NAQ   CAT    sing N N 150 
EQN   NAQ   HNAQ   sing N N 151 
EQN   CAR   CAU    sing N N 152 
EQN   CAS   CAV    sing N N 153 
EQN   CAW   CAX    doub Y N 154 
EQN   CAW   CAZ    sing N N 155 
EQN   CAX   CAY    sing N N 156 
EQN   OAG   H25    sing N N 157 
GLN   N     CA     sing N N 158 
GLN   N     H      sing N N 159 
GLN   N     H2     sing N N 160 
GLN   CA    C      sing N N 161 
GLN   CA    CB     sing N N 162 
GLN   CA    HA     sing N N 163 
GLN   C     O      doub N N 164 
GLN   C     OXT    sing N N 165 
GLN   CB    CG     sing N N 166 
GLN   CB    HB2    sing N N 167 
GLN   CB    HB3    sing N N 168 
GLN   CG    CD     sing N N 169 
GLN   CG    HG2    sing N N 170 
GLN   CG    HG3    sing N N 171 
GLN   CD    OE1    doub N N 172 
GLN   CD    NE2    sing N N 173 
GLN   NE2   HE21   sing N N 174 
GLN   NE2   HE22   sing N N 175 
GLN   OXT   HXT    sing N N 176 
GLU   N     CA     sing N N 177 
GLU   N     H      sing N N 178 
GLU   N     H2     sing N N 179 
GLU   CA    C      sing N N 180 
GLU   CA    CB     sing N N 181 
GLU   CA    HA     sing N N 182 
GLU   C     O      doub N N 183 
GLU   C     OXT    sing N N 184 
GLU   CB    CG     sing N N 185 
GLU   CB    HB2    sing N N 186 
GLU   CB    HB3    sing N N 187 
GLU   CG    CD     sing N N 188 
GLU   CG    HG2    sing N N 189 
GLU   CG    HG3    sing N N 190 
GLU   CD    OE1    doub N N 191 
GLU   CD    OE2    sing N N 192 
GLU   OE2   HE2    sing N N 193 
GLU   OXT   HXT    sing N N 194 
GLY   N     CA     sing N N 195 
GLY   N     H      sing N N 196 
GLY   N     H2     sing N N 197 
GLY   CA    C      sing N N 198 
GLY   CA    HA2    sing N N 199 
GLY   CA    HA3    sing N N 200 
GLY   C     O      doub N N 201 
GLY   C     OXT    sing N N 202 
GLY   OXT   HXT    sing N N 203 
HIS   N     CA     sing N N 204 
HIS   N     H      sing N N 205 
HIS   N     H2     sing N N 206 
HIS   CA    C      sing N N 207 
HIS   CA    CB     sing N N 208 
HIS   CA    HA     sing N N 209 
HIS   C     O      doub N N 210 
HIS   C     OXT    sing N N 211 
HIS   CB    CG     sing N N 212 
HIS   CB    HB2    sing N N 213 
HIS   CB    HB3    sing N N 214 
HIS   CG    ND1    sing Y N 215 
HIS   CG    CD2    doub Y N 216 
HIS   ND1   CE1    doub Y N 217 
HIS   ND1   HD1    sing N N 218 
HIS   CD2   NE2    sing Y N 219 
HIS   CD2   HD2    sing N N 220 
HIS   CE1   NE2    sing Y N 221 
HIS   CE1   HE1    sing N N 222 
HIS   NE2   HE2    sing N N 223 
HIS   OXT   HXT    sing N N 224 
HOH   O     H1     sing N N 225 
HOH   O     H2     sing N N 226 
HRG   N     CA     sing N N 227 
HRG   N     H      sing N N 228 
HRG   N     H2     sing N N 229 
HRG   CA    CB     sing N N 230 
HRG   CA    C      sing N N 231 
HRG   CA    HA     sing N N 232 
HRG   CB    "CG'"  sing N N 233 
HRG   CB    HB1    sing N N 234 
HRG   CB    HB2    sing N N 235 
HRG   CG    "CG'"  sing N N 236 
HRG   CG    CD     sing N N 237 
HRG   CG    HG1    sing N N 238 
HRG   CG    HG2    sing N N 239 
HRG   "CG'" "HG'1" sing N N 240 
HRG   "CG'" "HG'2" sing N N 241 
HRG   CD    NE     sing N N 242 
HRG   CD    HD1    sing N N 243 
HRG   CD    HD2    sing N N 244 
HRG   NE    CZ     sing N N 245 
HRG   NE    HNE    sing N N 246 
HRG   CZ    NH1    doub N N 247 
HRG   CZ    NH2    sing N N 248 
HRG   NH1   HN1    sing N N 249 
HRG   NH2   HN21   sing N N 250 
HRG   NH2   HN22   sing N N 251 
HRG   C     O      doub N N 252 
HRG   C     OXT    sing N N 253 
HRG   OXT   HXT    sing N N 254 
ILE   N     CA     sing N N 255 
ILE   N     H      sing N N 256 
ILE   N     H2     sing N N 257 
ILE   CA    C      sing N N 258 
ILE   CA    CB     sing N N 259 
ILE   CA    HA     sing N N 260 
ILE   C     O      doub N N 261 
ILE   C     OXT    sing N N 262 
ILE   CB    CG1    sing N N 263 
ILE   CB    CG2    sing N N 264 
ILE   CB    HB     sing N N 265 
ILE   CG1   CD1    sing N N 266 
ILE   CG1   HG12   sing N N 267 
ILE   CG1   HG13   sing N N 268 
ILE   CG2   HG21   sing N N 269 
ILE   CG2   HG22   sing N N 270 
ILE   CG2   HG23   sing N N 271 
ILE   CD1   HD11   sing N N 272 
ILE   CD1   HD12   sing N N 273 
ILE   CD1   HD13   sing N N 274 
ILE   OXT   HXT    sing N N 275 
LEU   N     CA     sing N N 276 
LEU   N     H      sing N N 277 
LEU   N     H2     sing N N 278 
LEU   CA    C      sing N N 279 
LEU   CA    CB     sing N N 280 
LEU   CA    HA     sing N N 281 
LEU   C     O      doub N N 282 
LEU   C     OXT    sing N N 283 
LEU   CB    CG     sing N N 284 
LEU   CB    HB2    sing N N 285 
LEU   CB    HB3    sing N N 286 
LEU   CG    CD1    sing N N 287 
LEU   CG    CD2    sing N N 288 
LEU   CG    HG     sing N N 289 
LEU   CD1   HD11   sing N N 290 
LEU   CD1   HD12   sing N N 291 
LEU   CD1   HD13   sing N N 292 
LEU   CD2   HD21   sing N N 293 
LEU   CD2   HD22   sing N N 294 
LEU   CD2   HD23   sing N N 295 
LEU   OXT   HXT    sing N N 296 
LYS   N     CA     sing N N 297 
LYS   N     H      sing N N 298 
LYS   N     H2     sing N N 299 
LYS   CA    C      sing N N 300 
LYS   CA    CB     sing N N 301 
LYS   CA    HA     sing N N 302 
LYS   C     O      doub N N 303 
LYS   C     OXT    sing N N 304 
LYS   CB    CG     sing N N 305 
LYS   CB    HB2    sing N N 306 
LYS   CB    HB3    sing N N 307 
LYS   CG    CD     sing N N 308 
LYS   CG    HG2    sing N N 309 
LYS   CG    HG3    sing N N 310 
LYS   CD    CE     sing N N 311 
LYS   CD    HD2    sing N N 312 
LYS   CD    HD3    sing N N 313 
LYS   CE    NZ     sing N N 314 
LYS   CE    HE2    sing N N 315 
LYS   CE    HE3    sing N N 316 
LYS   NZ    HZ1    sing N N 317 
LYS   NZ    HZ2    sing N N 318 
LYS   NZ    HZ3    sing N N 319 
LYS   OXT   HXT    sing N N 320 
MET   N     CA     sing N N 321 
MET   N     H      sing N N 322 
MET   N     H2     sing N N 323 
MET   CA    C      sing N N 324 
MET   CA    CB     sing N N 325 
MET   CA    HA     sing N N 326 
MET   C     O      doub N N 327 
MET   C     OXT    sing N N 328 
MET   CB    CG     sing N N 329 
MET   CB    HB2    sing N N 330 
MET   CB    HB3    sing N N 331 
MET   CG    SD     sing N N 332 
MET   CG    HG2    sing N N 333 
MET   CG    HG3    sing N N 334 
MET   SD    CE     sing N N 335 
MET   CE    HE1    sing N N 336 
MET   CE    HE2    sing N N 337 
MET   CE    HE3    sing N N 338 
MET   OXT   HXT    sing N N 339 
NLE   N     CA     sing N N 340 
NLE   N     H      sing N N 341 
NLE   N     H2     sing N N 342 
NLE   CA    C      sing N N 343 
NLE   CA    CB     sing N N 344 
NLE   CA    HA     sing N N 345 
NLE   C     O      doub N N 346 
NLE   C     OXT    sing N N 347 
NLE   OXT   HXT    sing N N 348 
NLE   CB    CG     sing N N 349 
NLE   CB    HB2    sing N N 350 
NLE   CB    HB3    sing N N 351 
NLE   CG    CD     sing N N 352 
NLE   CG    HG2    sing N N 353 
NLE   CG    HG3    sing N N 354 
NLE   CD    CE     sing N N 355 
NLE   CD    HD2    sing N N 356 
NLE   CD    HD3    sing N N 357 
NLE   CE    HE1    sing N N 358 
NLE   CE    HE2    sing N N 359 
NLE   CE    HE3    sing N N 360 
PHE   N     CA     sing N N 361 
PHE   N     H      sing N N 362 
PHE   N     H2     sing N N 363 
PHE   CA    C      sing N N 364 
PHE   CA    CB     sing N N 365 
PHE   CA    HA     sing N N 366 
PHE   C     O      doub N N 367 
PHE   C     OXT    sing N N 368 
PHE   CB    CG     sing N N 369 
PHE   CB    HB2    sing N N 370 
PHE   CB    HB3    sing N N 371 
PHE   CG    CD1    doub Y N 372 
PHE   CG    CD2    sing Y N 373 
PHE   CD1   CE1    sing Y N 374 
PHE   CD1   HD1    sing N N 375 
PHE   CD2   CE2    doub Y N 376 
PHE   CD2   HD2    sing N N 377 
PHE   CE1   CZ     doub Y N 378 
PHE   CE1   HE1    sing N N 379 
PHE   CE2   CZ     sing Y N 380 
PHE   CE2   HE2    sing N N 381 
PHE   CZ    HZ     sing N N 382 
PHE   OXT   HXT    sing N N 383 
PRO   N     CA     sing N N 384 
PRO   N     CD     sing N N 385 
PRO   N     H      sing N N 386 
PRO   CA    C      sing N N 387 
PRO   CA    CB     sing N N 388 
PRO   CA    HA     sing N N 389 
PRO   C     O      doub N N 390 
PRO   C     OXT    sing N N 391 
PRO   CB    CG     sing N N 392 
PRO   CB    HB2    sing N N 393 
PRO   CB    HB3    sing N N 394 
PRO   CG    CD     sing N N 395 
PRO   CG    HG2    sing N N 396 
PRO   CG    HG3    sing N N 397 
PRO   CD    HD2    sing N N 398 
PRO   CD    HD3    sing N N 399 
PRO   OXT   HXT    sing N N 400 
SER   N     CA     sing N N 401 
SER   N     H      sing N N 402 
SER   N     H2     sing N N 403 
SER   CA    C      sing N N 404 
SER   CA    CB     sing N N 405 
SER   CA    HA     sing N N 406 
SER   C     O      doub N N 407 
SER   C     OXT    sing N N 408 
SER   CB    OG     sing N N 409 
SER   CB    HB2    sing N N 410 
SER   CB    HB3    sing N N 411 
SER   OG    HG     sing N N 412 
SER   OXT   HXT    sing N N 413 
THR   N     CA     sing N N 414 
THR   N     H      sing N N 415 
THR   N     H2     sing N N 416 
THR   CA    C      sing N N 417 
THR   CA    CB     sing N N 418 
THR   CA    HA     sing N N 419 
THR   C     O      doub N N 420 
THR   C     OXT    sing N N 421 
THR   CB    OG1    sing N N 422 
THR   CB    CG2    sing N N 423 
THR   CB    HB     sing N N 424 
THR   OG1   HG1    sing N N 425 
THR   CG2   HG21   sing N N 426 
THR   CG2   HG22   sing N N 427 
THR   CG2   HG23   sing N N 428 
THR   OXT   HXT    sing N N 429 
TRP   N     CA     sing N N 430 
TRP   N     H      sing N N 431 
TRP   N     H2     sing N N 432 
TRP   CA    C      sing N N 433 
TRP   CA    CB     sing N N 434 
TRP   CA    HA     sing N N 435 
TRP   C     O      doub N N 436 
TRP   C     OXT    sing N N 437 
TRP   CB    CG     sing N N 438 
TRP   CB    HB2    sing N N 439 
TRP   CB    HB3    sing N N 440 
TRP   CG    CD1    doub Y N 441 
TRP   CG    CD2    sing Y N 442 
TRP   CD1   NE1    sing Y N 443 
TRP   CD1   HD1    sing N N 444 
TRP   CD2   CE2    doub Y N 445 
TRP   CD2   CE3    sing Y N 446 
TRP   NE1   CE2    sing Y N 447 
TRP   NE1   HE1    sing N N 448 
TRP   CE2   CZ2    sing Y N 449 
TRP   CE3   CZ3    doub Y N 450 
TRP   CE3   HE3    sing N N 451 
TRP   CZ2   CH2    doub Y N 452 
TRP   CZ2   HZ2    sing N N 453 
TRP   CZ3   CH2    sing Y N 454 
TRP   CZ3   HZ3    sing N N 455 
TRP   CH2   HH2    sing N N 456 
TRP   OXT   HXT    sing N N 457 
TYR   N     CA     sing N N 458 
TYR   N     H      sing N N 459 
TYR   N     H2     sing N N 460 
TYR   CA    C      sing N N 461 
TYR   CA    CB     sing N N 462 
TYR   CA    HA     sing N N 463 
TYR   C     O      doub N N 464 
TYR   C     OXT    sing N N 465 
TYR   CB    CG     sing N N 466 
TYR   CB    HB2    sing N N 467 
TYR   CB    HB3    sing N N 468 
TYR   CG    CD1    doub Y N 469 
TYR   CG    CD2    sing Y N 470 
TYR   CD1   CE1    sing Y N 471 
TYR   CD1   HD1    sing N N 472 
TYR   CD2   CE2    doub Y N 473 
TYR   CD2   HD2    sing N N 474 
TYR   CE1   CZ     doub Y N 475 
TYR   CE1   HE1    sing N N 476 
TYR   CE2   CZ     sing Y N 477 
TYR   CE2   HE2    sing N N 478 
TYR   CZ    OH     sing N N 479 
TYR   OH    HH     sing N N 480 
TYR   OXT   HXT    sing N N 481 
VAL   N     CA     sing N N 482 
VAL   N     H      sing N N 483 
VAL   N     H2     sing N N 484 
VAL   CA    C      sing N N 485 
VAL   CA    CB     sing N N 486 
VAL   CA    HA     sing N N 487 
VAL   C     O      doub N N 488 
VAL   C     OXT    sing N N 489 
VAL   CB    CG1    sing N N 490 
VAL   CB    CG2    sing N N 491 
VAL   CB    HB     sing N N 492 
VAL   CG1   HG11   sing N N 493 
VAL   CG1   HG12   sing N N 494 
VAL   CG1   HG13   sing N N 495 
VAL   CG2   HG21   sing N N 496 
VAL   CG2   HG22   sing N N 497 
VAL   CG2   HG23   sing N N 498 
VAL   OXT   HXT    sing N N 499 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Agence Nationale de la Recherche (ANR)' France ANR-15-CE07-0010 1 
'Agence Nationale de la Recherche (ANR)' France ANR-17-CE07-0020 2 
'Agence Nationale de la Recherche (ANR)' France ANR-20-CE18-0038 3 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   3KMR 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9GFI 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.011427 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.003184 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.016113 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.021035 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N     . LEU   A 1 1   ? 30.775 26.167  14.249 1    82.01  ?  180 LEU   A N     1 
ATOM   2    C CA    . LEU   A 1 1   ? 30.879 27.482  14.877 1    82.54  ?  180 LEU   A CA    1 
ATOM   3    C C     . LEU   A 1 1   ? 29.539 28.015  15.381 1    82.57  ?  180 LEU   A C     1 
ATOM   4    O O     . LEU   A 1 1   ? 29.504 28.766  16.353 1    82.79  ?  180 LEU   A O     1 
ATOM   5    C CB    . LEU   A 1 1   ? 31.57  28.492  13.953 1    83.04  ?  180 LEU   A CB    1 
ATOM   6    C CG    . LEU   A 1 1   ? 33.099 28.382  13.91  1    85.22  ?  180 LEU   A CG    1 
ATOM   7    C CD1   . LEU   A 1 1   ? 33.694 29.307  12.851 1    85.96  ?  180 LEU   A CD1   1 
ATOM   8    C CD2   . LEU   A 1 1   ? 33.714 28.668  15.279 1    86.01  ?  180 LEU   A CD2   1 
ATOM   9    N N     . THR   A 1 2   ? 28.439 27.627  14.736 1    82.15  ?  181 THR   A N     1 
ATOM   10   C CA    . THR   A 1 2   ? 27.098 28.043  15.168 1    82.17  ?  181 THR   A CA    1 
ATOM   11   C C     . THR   A 1 2   ? 26.744 27.272  16.468 1    82.01  ?  181 THR   A C     1 
ATOM   12   O O     . THR   A 1 2   ? 27.176 26.13   16.641 1    82.42  ?  181 THR   A O     1 
ATOM   13   C CB    . THR   A 1 2   ? 26.017 27.985  14.01  1    83.39  ?  181 THR   A CB    1 
ATOM   14   O OG1   . THR   A 1 2   ? 24.821 27.321  14.437 1    84.1   ?  181 THR   A OG1   1 
ATOM   15   C CG2   . THR   A 1 2   ? 26.526 27.374  12.681 1    83.81  ?  181 THR   A CG2   1 
ATOM   16   N N     . PRO   A 1 3   ? 26.01  27.892  17.415 1    81.19  ?  182 PRO   A N     1 
ATOM   17   C CA    . PRO   A 1 3   ? 25.702 27.193  18.676 1    80.14  ?  182 PRO   A CA    1 
ATOM   18   C C     . PRO   A 1 3   ? 24.924 25.887  18.527 1    78.52  ?  182 PRO   A C     1 
ATOM   19   O O     . PRO   A 1 3   ? 25.256 24.918  19.201 1    78.61  ?  182 PRO   A O     1 
ATOM   20   C CB    . PRO   A 1 3   ? 24.923 28.236  19.488 1    81.16  ?  182 PRO   A CB    1 
ATOM   21   C CG    . PRO   A 1 3   ? 24.404 29.206  18.483 1    81.94  ?  182 PRO   A CG    1 
ATOM   22   C CD    . PRO   A 1 3   ? 25.445 29.257  17.402 1    80.72  ?  182 PRO   A CD    1 
ATOM   23   N N     . GLU   A 1 4   ? 23.911 25.85   17.647 1    76.85  ?  183 GLU   A N     1 
ATOM   24   C CA    . GLU   A 1 4   ? 23.097 24.649  17.44  1    75.62  ?  183 GLU   A CA    1 
ATOM   25   C C     . GLU   A 1 4   ? 23.868 23.55   16.715 1    73.47  ?  183 GLU   A C     1 
ATOM   26   O O     . GLU   A 1 4   ? 23.672 22.372  16.996 1    73.56  ?  183 GLU   A O     1 
ATOM   27   C CB    . GLU   A 1 4   ? 21.809 24.99   16.671 1    78.26  ?  183 GLU   A CB    1 
ATOM   28   C CG    . GLU   A 1 4   ? 20.545 24.581  17.402 1    83.85  ?  183 GLU   A CG    1 
ATOM   29   C CD    . GLU   A 1 4   ? 20.303 23.085  17.456 1    91.42  ?  183 GLU   A CD    1 
ATOM   30   O OE1   . GLU   A 1 4   ? 20.481 22.421  16.409 1    94.26  ?  183 GLU   A OE1   1 
ATOM   31   O OE2   . GLU   A 1 4   ? 19.934 22.574  18.539 1    92.68  ?  183 GLU   A OE2   1 
ATOM   32   N N     . VAL   A 1 5   ? 24.732 23.936  15.775 1    71.42  ?  184 VAL   A N     1 
ATOM   33   C CA    . VAL   A 1 5   ? 25.527 22.99   15.008 1    69.83  ?  184 VAL   A CA    1 
ATOM   34   C C     . VAL   A 1 5   ? 26.571 22.319  15.904 1    68.32  ?  184 VAL   A C     1 
ATOM   35   O O     . VAL   A 1 5   ? 26.723 21.1    15.86  1    68.59  ?  184 VAL   A O     1 
ATOM   36   C CB    . VAL   A 1 5   ? 26.142 23.673  13.758 1    70.1   ?  184 VAL   A CB    1 
ATOM   37   C CG1   . VAL   A 1 5   ? 27.263 22.843  13.153 1    70.41  ?  184 VAL   A CG1   1 
ATOM   38   C CG2   . VAL   A 1 5   ? 25.07  23.971  12.719 1    70.41  ?  184 VAL   A CG2   1 
ATOM   39   N N     . GLY   A 1 6   ? 27.241 23.105  16.732 1    66.62  ?  185 GLY   A N     1 
ATOM   40   C CA    . GLY   A 1 6   ? 28.249 22.588  17.646 1    65.64  ?  185 GLY   A CA    1 
ATOM   41   C C     . GLY   A 1 6   ? 27.711 21.558  18.62  1    64.49  ?  185 GLY   A C     1 
ATOM   42   O O     . GLY   A 1 6   ? 28.393 20.582  18.931 1    64.77  ?  185 GLY   A O     1 
ATOM   43   N N     . GLU   A 1 7   ? 26.478 21.757  19.098 1    63.18  ?  186 GLU   A N     1 
ATOM   44   C CA    . GLU   A 1 7   ? 25.847 20.83   20.029 1    62.44  ?  186 GLU   A CA    1 
ATOM   45   C C     . GLU   A 1 7   ? 25.474 19.535  19.325 1    60.6   ?  186 GLU   A C     1 
ATOM   46   O O     . GLU   A 1 7   ? 25.587 18.468  19.927 1    60.51  ?  186 GLU   A O     1 
ATOM   47   C CB    . GLU   A 1 7   ? 24.576 21.438  20.637 1    65.74  ?  186 GLU   A CB    1 
ATOM   48   C CG    . GLU   A 1 7   ? 24.798 22.635  21.545 1    72.72  ?  186 GLU   A CG    1 
ATOM   49   C CD    . GLU   A 1 7   ? 23.556 23.473  21.801 1    81.61  ?  186 GLU   A CD    1 
ATOM   50   O OE1   . GLU   A 1 7   ? 22.455 23.078  21.347 1    82.85  ?  186 GLU   A OE1   1 
ATOM   51   O OE2   . GLU   A 1 7   ? 23.688 24.537  22.45  1    84.75  ?  186 GLU   A OE2   1 
ATOM   52   N N     . LEU   A 1 8   ? 24.986 19.624  18.067 1    58.83  ?  187 LEU   A N     1 
ATOM   53   C CA    . LEU   A 1 8   ? 24.586 18.433  17.318 1    57.3   ?  187 LEU   A CA    1 
ATOM   54   C C     . LEU   A 1 8   ? 25.8   17.563  17.05  1    56.02  ?  187 LEU   A C     1 
ATOM   55   O O     . LEU   A 1 8   ? 25.743 16.36   17.282 1    55.69  ?  187 LEU   A O     1 
ATOM   56   C CB    . LEU   A 1 8   ? 23.875 18.778  16.01  1    56.99  ?  187 LEU   A CB    1 
ATOM   57   C CG    . LEU   A 1 8   ? 23.332 17.566  15.282 1    57.95  ?  187 LEU   A CG    1 
ATOM   58   C CD1   . LEU   A 1 8   ? 22.172 16.976  16.012 1    57.88  ?  187 LEU   A CD1   1 
ATOM   59   C CD2   . LEU   A 1 8   ? 22.932 17.901  13.887 1    58.88  ?  187 LEU   A CD2   1 
ATOM   60   N N     . ILE   A 1 9   ? 26.912 18.192  16.633 1    55.14  ?  188 ILE   A N     1 
ATOM   61   C CA    . ILE   A 1 9   ? 28.191 17.541  16.371 1    54.83  ?  188 ILE   A CA    1 
ATOM   62   C C     . ILE   A 1 9   ? 28.709 16.853  17.634 1    53.59  ?  188 ILE   A C     1 
ATOM   63   O O     . ILE   A 1 9   ? 29.121 15.698  17.578 1    53.52  ?  188 ILE   A O     1 
ATOM   64   C CB    . ILE   A 1 9   ? 29.214 18.571  15.806 1    55.7   ?  188 ILE   A CB    1 
ATOM   65   C CG1   . ILE   A 1 9   ? 28.812 19.01   14.387 1    57.25  ?  188 ILE   A CG1   1 
ATOM   66   C CG2   . ILE   A 1 9   ? 30.651 18.03   15.831 1    56.01  ?  188 ILE   A CG2   1 
ATOM   67   C CD1   . ILE   A 1 9   ? 29.65  20.141  13.821 1    59.06  ?  188 ILE   A CD1   1 
ATOM   68   N N     . GLU   A 1 10  ? 28.668 17.555  18.766 1    52.64  ?  189 GLU   A N     1 
ATOM   69   C CA    . GLU   A 1 10  ? 29.123 17.018  20.044 1    52.49  ?  189 GLU   A CA    1 
ATOM   70   C C     . GLU   A 1 10  ? 28.309 15.798  20.47  1    50.5   ?  189 GLU   A C     1 
ATOM   71   O O     . GLU   A 1 10  ? 28.881 14.818  20.94  1    50.54  ?  189 GLU   A O     1 
ATOM   72   C CB    . GLU   A 1 10  ? 29.086 18.107  21.14  1    56.31  ?  189 GLU   A CB    1 
ATOM   73   C CG    . GLU   A 1 10  ? 29.53  17.63   22.513 1    64.16  ?  189 GLU   A CG    1 
ATOM   74   C CD    . GLU   A 1 10  ? 31.005 17.299  22.657 1    75.22  ?  189 GLU   A CD    1 
ATOM   75   O OE1   . GLU   A 1 10  ? 31.433 16.224  22.173 1    77.33  ?  189 GLU   A OE1   1 
ATOM   76   O OE2   . GLU   A 1 10  ? 31.732 18.109  23.28  1    79.1   ?  189 GLU   A OE2   1 
ATOM   77   N N     . LYS   A 1 11  ? 26.989 15.859  20.298 1    48.82  ?  190 LYS   A N     1 
ATOM   78   C CA    . LYS   A 1 11  ? 26.077 14.774  20.631 1    47.83  ?  190 LYS   A CA    1 
ATOM   79   C C     . LYS   A 1 11  ? 26.321 13.521  19.788 1    46.29  ?  190 LYS   A C     1 
ATOM   80   O O     . LYS   A 1 11  ? 26.284 12.417  20.324 1    46.23  ?  190 LYS   A O     1 
ATOM   81   C CB    . LYS   A 1 11  ? 24.614 15.226  20.476 1    50.27  ?  190 LYS   A CB    1 
ATOM   82   C CG    . LYS   A 1 11  ? 23.964 15.613  21.797 1    56.53  ?  190 LYS   A CG    1 
ATOM   83   C CD    . LYS   A 1 11  ? 22.507 16.039  21.63  1    62.77  ?  190 LYS   A CD    1 
ATOM   84   C CE    . LYS   A 1 11  ? 22.149 17.23   22.495 1    67.09  ?  190 LYS   A CE    1 
ATOM   85   N NZ    . LYS   A 1 11  ? 22.813 17.154  23.823 1    69.65  ?  190 LYS   A NZ    1 
ATOM   86   N N     . VAL   A 1 12  ? 26.534 13.683  18.481 1    45.02  ?  191 VAL   A N     1 
ATOM   87   C CA    . VAL   A 1 12  ? 26.744 12.555  17.599 1    44.88  ?  191 VAL   A CA    1 
ATOM   88   C C     . VAL   A 1 12  ? 28.147 11.968  17.781 1    45.13  ?  191 VAL   A C     1 
ATOM   89   O O     . VAL   A 1 12  ? 28.301 10.744  17.828 1    44.77  ?  191 VAL   A O     1 
ATOM   90   C CB    . VAL   A 1 12  ? 26.405 12.88   16.125 1    45.58  ?  191 VAL   A CB    1 
ATOM   91   C CG1   . VAL   A 1 12  ? 26.682 11.677  15.241 1    46.16  ?  191 VAL   A CG1   1 
ATOM   92   C CG2   . VAL   A 1 12  ? 24.945 13.304  15.976 1    46.09  ?  191 VAL   A CG2   1 
ATOM   93   N N     . ARG   A 1 13  ? 29.166 12.824  17.985 1    45.28  ?  192 ARG   A N     1 
ATOM   94   C CA    . ARG   A 1 13  ? 30.531 12.339  18.219 1    45.84  ?  192 ARG   A CA    1 
ATOM   95   C C     . ARG   A 1 13  ? 30.557 11.501  19.504 1    45.93  ?  192 ARG   A C     1 
ATOM   96   O O     . ARG   A 1 13  ? 31.077 10.398  19.495 1    45.98  ?  192 ARG   A O     1 
ATOM   97   C CB    . ARG   A 1 13  ? 31.534 13.508  18.307 1    47.49  ?  192 ARG   A CB    1 
ATOM   98   C CG    . ARG   A 1 13  ? 32.94  13.088  18.728 1    51.59  ?  192 ARG   A CG    1 
ATOM   99   C CD    . ARG   A 1 13  ? 33.68  14.209  19.432 1    56.54  ?  192 ARG   A CD    1 
ATOM   100  N NE    . ARG   A 1 13  ? 34.329 15.111  18.479 1    61.94  ?  192 ARG   A NE    1 
ATOM   101  C CZ    . ARG   A 1 13  ? 33.981 16.379  18.278 1    64.86  ?  192 ARG   A CZ    1 
ATOM   102  N NH1   . ARG   A 1 13  ? 32.993 16.923  18.978 1    64.03  ?  192 ARG   A NH1   1 
ATOM   103  N NH2   . ARG   A 1 13  ? 34.625 17.115  17.382 1    65.53  ?  192 ARG   A NH2   1 
ATOM   104  N N     . LYS   A 1 14  ? 29.897 11.994  20.554 1    45.81  ?  193 LYS   A N     1 
ATOM   105  C CA    . LYS   A 1 14  ? 29.774 11.345  21.859 1    46     ?  193 LYS   A CA    1 
ATOM   106  C C     . LYS   A 1 14  ? 28.999 10.04   21.739 1    44.11  ?  193 LYS   A C     1 
ATOM   107  O O     . LYS   A 1 14  ? 29.396 9.046   22.327 1    44.27  ?  193 LYS   A O     1 
ATOM   108  C CB    . LYS   A 1 14  ? 29.074 12.298  22.845 1    49.7   ?  193 LYS   A CB    1 
ATOM   109  C CG    . LYS   A 1 14  ? 28.822 11.731  24.233 1    56.24  ?  193 LYS   A CG    1 
ATOM   110  C CD    . LYS   A 1 14  ? 27.999 12.693  25.086 1    62.1   ?  193 LYS   A CD    1 
ATOM   111  C CE    . LYS   A 1 14  ? 27.703 12.141  26.463 1    66.77  ?  193 LYS   A CE    1 
ATOM   112  N NZ    . LYS   A 1 14  ? 26.842 10.926  26.406 1    69.71  ?  193 LYS   A NZ    1 
ATOM   113  N N     . ALA   A 1 15  ? 27.925 10.028  20.95  1    42.54  ?  194 ALA   A N     1 
ATOM   114  C CA    . ALA   A 1 15  ? 27.131 8.809   20.745 1    41.55  ?  194 ALA   A CA    1 
ATOM   115  C C     . ALA   A 1 15  ? 27.992 7.697   20.096 1    40.11  ?  194 ALA   A C     1 
ATOM   116  O O     . ALA   A 1 15  ? 27.914 6.539   20.505 1    40.25  ?  194 ALA   A O     1 
ATOM   117  C CB    . ALA   A 1 15  ? 25.916 9.107   19.869 1    41.32  ?  194 ALA   A CB    1 
ATOM   118  N N     . HIS   A 1 16  ? 28.789 8.055   19.085 1    38.24  ?  195 HIS   A N     1 
ATOM   119  C CA    . HIS   A 1 16  ? 29.632 7.109   18.385 1    37.72  ?  195 HIS   A CA    1 
ATOM   120  C C     . HIS   A 1 16  ? 30.761 6.633   19.3   1    38.21  ?  195 HIS   A C     1 
ATOM   121  O O     . HIS   A 1 16  ? 30.942 5.438   19.48  1    38.24  ?  195 HIS   A O     1 
ATOM   122  C CB    . HIS   A 1 16  ? 30.198 7.75    17.111 1    37.25  ?  195 HIS   A CB    1 
ATOM   123  C CG    . HIS   A 1 16  ? 31.242 6.926   16.429 1    38.8   ?  195 HIS   A CG    1 
ATOM   124  N ND1   . HIS   A 1 16  ? 30.914 5.758   15.755 1    40.35  ?  195 HIS   A ND1   1 
ATOM   125  C CD2   . HIS   A 1 16  ? 32.579 7.12    16.35  1    39.31  ?  195 HIS   A CD2   1 
ATOM   126  C CE1   . HIS   A 1 16  ? 32.058 5.297   15.275 1    40.53  ?  195 HIS   A CE1   1 
ATOM   127  N NE2   . HIS   A 1 16  ? 33.084 6.084   15.611 1    40.31  ?  195 HIS   A NE2   1 
ATOM   128  N N     . GLN   A 1 17  ? 31.486 7.566   19.899 1    38.25  ?  196 GLN   A N     1 
ATOM   129  C CA    . GLN   A 1 17  ? 32.593 7.281   20.779 1    39.48  ?  196 GLN   A CA    1 
ATOM   130  C C     . GLN   A 1 17  ? 32.183 6.364   21.937 1    38.42  ?  196 GLN   A C     1 
ATOM   131  O O     . GLN   A 1 17  ? 32.862 5.379   22.188 1    38.93  ?  196 GLN   A O     1 
ATOM   132  C CB    . GLN   A 1 17  ? 33.175 8.605   21.295 1    43.34  ?  196 GLN   A CB    1 
ATOM   133  C CG    . GLN   A 1 17  ? 34.63  8.569   21.689 1    50.49  ?  196 GLN   A CG    1 
ATOM   134  C CD    . GLN   A 1 17  ? 35.084 9.965   22.061 1    58.59  ?  196 GLN   A CD    1 
ATOM   135  O OE1   . GLN   A 1 17  ? 35.134 10.88   21.213 1    60.16  ?  196 GLN   A OE1   1 
ATOM   136  N NE2   . GLN   A 1 17  ? 35.418 10.161  23.341 1    60.35  ?  196 GLN   A NE2   1 
ATOM   137  N N     . GLU   A 1 18  ? 31.033 6.612   22.554 1    37.51  ?  197 GLU   A N     1 
ATOM   138  C CA    . GLU   A 1 18  ? 30.576 5.812   23.691 1    37.59  ?  197 GLU   A CA    1 
ATOM   139  C C     . GLU   A 1 18  ? 29.995 4.453   23.335 1    36.85  ?  197 GLU   A C     1 
ATOM   140  O O     . GLU   A 1 18  ? 29.752 3.653   24.233 1    37.29  ?  197 GLU   A O     1 
ATOM   141  C CB    . GLU   A 1 18  ? 29.594 6.611   24.551 1    41.13  ?  197 GLU   A CB    1 
ATOM   142  C CG    . GLU   A 1 18  ? 30.305 7.81    25.148 1    47.91  ?  197 GLU   A CG    1 
ATOM   143  C CD    . GLU   A 1 18  ? 29.477 8.75    25.997 1    58.96  ?  197 GLU   A CD    1 
ATOM   144  O OE1   . GLU   A 1 18  ? 28.235 8.585   26.052 1    61.17  ?  197 GLU   A OE1   1 
ATOM   145  O OE2   . GLU   A 1 18  ? 30.08  9.663   26.608 1    63.33  ?  197 GLU   A OE2   1 
ATOM   146  N N     . THR   A 1 19  ? 29.785 4.168   22.046 1    35.36  ?  198 THR   A N     1 
ATOM   147  C CA    . THR   A 1 19  ? 29.314 2.853   21.626 1    34.2   ?  198 THR   A CA    1 
ATOM   148  C C     . THR   A 1 19  ? 30.34  2.153   20.709 1    33.08  ?  198 THR   A C     1 
ATOM   149  O O     . THR   A 1 19  ? 30.035 1.099   20.173 1    32.56  ?  198 THR   A O     1 
ATOM   150  C CB    . THR   A 1 19  ? 27.962 2.966   20.884 1    34.52  ?  198 THR   A CB    1 
ATOM   151  O OG1   . THR   A 1 19  ? 28.161 3.797   19.743 1    35.49  ?  198 THR   A OG1   1 
ATOM   152  C CG2   . THR   A 1 19  ? 26.816 3.502   21.778 1    33.38  ?  198 THR   A CG2   1 
ATOM   153  N N     . PHE   A 1 20  ? 31.529 2.729   20.504 1    33.34  ?  199 PHE   A N     1 
ATOM   154  C CA    . PHE   A 1 20  ? 32.506 2.181   19.57  1    33.65  ?  199 PHE   A CA    1 
ATOM   155  C C     . PHE   A 1 20  ? 33.909 2.282   20.106 1    34.39  ?  199 PHE   A C     1 
ATOM   156  O O     . PHE   A 1 20  ? 34.485 3.362   20.034 1    35.35  ?  199 PHE   A O     1 
ATOM   157  C CB    . PHE   A 1 20  ? 32.404 2.927   18.206 1    33.55  ?  199 PHE   A CB    1 
ATOM   158  C CG    . PHE   A 1 20  ? 33.359 2.449   17.128 1    34.5   ?  199 PHE   A CG    1 
ATOM   159  C CD1   . PHE   A 1 20  ? 33.102 1.291   16.414 1    35.11  ?  199 PHE   A CD1   1 
ATOM   160  C CD2   . PHE   A 1 20  ? 34.518 3.158   16.836 1    35.4   ?  199 PHE   A CD2   1 
ATOM   161  C CE1   . PHE   A 1 20  ? 34.004 0.832   15.451 1    35.67  ?  199 PHE   A CE1   1 
ATOM   162  C CE2   . PHE   A 1 20  ? 35.424 2.687   15.882 1    36.05  ?  199 PHE   A CE2   1 
ATOM   163  C CZ    . PHE   A 1 20  ? 35.145 1.545   15.175 1    35.47  ?  199 PHE   A CZ    1 
ATOM   164  N N     . PRO   A 1 21  ? 34.515 1.184   20.607 1    34.21  ?  200 PRO   A N     1 
ATOM   165  C CA    . PRO   A 1 21  ? 35.924 1.275   21.033 1    34.82  ?  200 PRO   A CA    1 
ATOM   166  C C     . PRO   A 1 21  ? 36.857 1.389   19.818 1    35.46  ?  200 PRO   A C     1 
ATOM   167  O O     . PRO   A 1 21  ? 36.624 0.743   18.794 1    36.33  ?  200 PRO   A O     1 
ATOM   168  C CB    . PRO   A 1 21  ? 36.151 -0.007  21.863 1    35.47  ?  200 PRO   A CB    1 
ATOM   169  C CG    . PRO   A 1 21  ? 35.041 -0.939  21.502 1    35.19  ?  200 PRO   A CG    1 
ATOM   170  C CD    . PRO   A 1 21  ? 33.967 -0.182  20.759 1    33.47  ?  200 PRO   A CD    1 
ATOM   171  N N     . ALA   A 1 22  ? 37.856 2.273   19.884 1    35.33  ?  201 ALA   A N     1 
ATOM   172  C CA    . ALA   A 1 22  ? 38.776 2.467   18.759 1    35.5   ?  201 ALA   A CA    1 
ATOM   173  C C     . ALA   A 1 22  ? 39.82  1.356   18.707 1    35.73  ?  201 ALA   A C     1 
ATOM   174  O O     . ALA   A 1 22  ? 40.133 0.757   19.725 1    35.25  ?  201 ALA   A O     1 
ATOM   175  C CB    . ALA   A 1 22  ? 39.457 3.816   18.859 1    35.09  ?  201 ALA   A CB    1 
ATOM   176  N N     . LEU   A 1 23  ? 40.373 1.089   17.518 1    36.28  ?  202 LEU   A N     1 
ATOM   177  C CA    . LEU   A 1 23  ? 41.422 0.09    17.303 1    37.35  ?  202 LEU   A CA    1 
ATOM   178  C C     . LEU   A 1 23  ? 42.602 0.288   18.298 1    37.66  ?  202 LEU   A C     1 
ATOM   179  O O     . LEU   A 1 23  ? 43.059 -0.675  18.907 1    37.93  ?  202 LEU   A O     1 
ATOM   180  C CB    . LEU   A 1 23  ? 41.902 0.173   15.832 1    37.93  ?  202 LEU   A CB    1 
ATOM   181  C CG    . LEU   A 1 23  ? 43.082 -0.724  15.413 1    40.25  ?  202 LEU   A CG    1 
ATOM   182  C CD1   . LEU   A 1 23  ? 42.813 -2.179  15.718 1    40.89  ?  202 LEU   A CD1   1 
ATOM   183  C CD2   . LEU   A 1 23  ? 43.402 -0.566  13.917 1    40.89  ?  202 LEU   A CD2   1 
ATOM   184  N N     . CYS   A 1 24  ? 43.006 1.54    18.534 1    37.68  ?  203 CYS   A N     1 
ATOM   185  C CA    . CYS   A 1 24  ? 44.11  1.867   19.447 1    38.07  ?  203 CYS   A CA    1 
ATOM   186  C C     . CYS   A 1 24  ? 43.835 1.477   20.903 1    37.11  ?  203 CYS   A C     1 
ATOM   187  O O     . CYS   A 1 24  ? 44.767 1.135   21.618 1    37.37  ?  203 CYS   A O     1 
ATOM   188  C CB    . CYS   A 1 24  ? 44.494 3.34    19.333 1    39.53  ?  203 CYS   A CB    1 
ATOM   189  S SG    . CYS   A 1 24  ? 43.259 4.478   20.021 1    45.37  ?  203 CYS   A SG    1 
ATOM   190  N N     . GLN   A 1 25  ? 42.572 1.549   21.349 1    35.84  ?  204 GLN   A N     1 
ATOM   191  C CA    . GLN   A 1 25  ? 42.193 1.192   22.712 1    35.21  ?  204 GLN   A CA    1 
ATOM   192  C C     . GLN   A 1 25  ? 42.166 -0.334  22.947 1    35.33  ?  204 GLN   A C     1 
ATOM   193  O O     . GLN   A 1 25  ? 42.195 -0.778  24.094 1    35.32  ?  204 GLN   A O     1 
ATOM   194  C CB    . GLN   A 1 25  ? 40.783 1.736   23.018 1    35.27  ?  204 GLN   A CB    1 
ATOM   195  C CG    . GLN   A 1 25  ? 40.633 3.228   22.87  1    37.14  ?  204 GLN   A CG    1 
ATOM   196  C CD    . GLN   A 1 25  ? 39.224 3.664   23.198 1    39.37  ?  204 GLN   A CD    1 
ATOM   197  O OE1   . GLN   A 1 25  ? 38.303 3.531   22.404 1    39.35  ?  204 GLN   A OE1   1 
ATOM   198  N NE2   . GLN   A 1 25  ? 39.018 4.203   24.378 1    40.13  ?  204 GLN   A NE2   1 
ATOM   199  N N     . LEU   A 1 26  ? 42.02  -1.126  21.884 1    35.04  ?  205 LEU   A N     1 
ATOM   200  C CA    . LEU   A 1 26  ? 41.856 -2.574  22.003 1    34.95  ?  205 LEU   A CA    1 
ATOM   201  C C     . LEU   A 1 26  ? 43.152 -3.36   21.957 1    34.9   ?  205 LEU   A C     1 
ATOM   202  O O     . LEU   A 1 26  ? 44.108 -2.947  21.311 1    35.5   ?  205 LEU   A O     1 
ATOM   203  C CB    . LEU   A 1 26  ? 40.922 -3.063  20.875 1    35.16  ?  205 LEU   A CB    1 
ATOM   204  C CG    . LEU   A 1 26  ? 39.529 -2.443  20.825 1    36.36  ?  205 LEU   A CG    1 
ATOM   205  C CD1   . LEU   A 1 26  ? 38.821 -2.803  19.512 1    36.69  ?  205 LEU   A CD1   1 
ATOM   206  C CD2   . LEU   A 1 26  ? 38.693 -2.9    22.005 1    36.82  ?  205 LEU   A CD2   1 
ATOM   207  N N     . GLY   A 1 27  ? 43.159 -4.51   22.615 1    34.41  ?  206 GLY   A N     1 
ATOM   208  C CA    . GLY   A 1 27  ? 44.297 -5.418  22.62  1    34.5   ?  206 GLY   A CA    1 
ATOM   209  C C     . GLY   A 1 27  ? 44.062 -6.496  21.59  1    35.38  ?  206 GLY   A C     1 
ATOM   210  O O     . GLY   A 1 27  ? 43.261 -7.418  21.801 1    35.6   ?  206 GLY   A O     1 
ATOM   211  N N     . LYS   A 1 28  ? 44.688 -6.319  20.423 1    35.66  ?  207 LYS   A N     1 
ATOM   212  C CA    . LYS   A 1 28  ? 44.574 -7.216  19.281 1    36.03  ?  207 LYS   A CA    1 
ATOM   213  C C     . LYS   A 1 28  ? 44.991 -8.641  19.615 1    36.66  ?  207 LYS   A C     1 
ATOM   214  O O     . LYS   A 1 28  ? 45.982 -8.852  20.311 1    37.7   ?  207 LYS   A O     1 
ATOM   215  C CB    . LYS   A 1 28  ? 45.449 -6.709  18.137 1    36.93  ?  207 LYS   A CB    1 
ATOM   216  C CG    . LYS   A 1 28  ? 44.99  -5.417  17.509 1    40.36  ?  207 LYS   A CG    1 
ATOM   217  C CD    . LYS   A 1 28  ? 45.541 -5.369  16.08  1    46.29  ?  207 LYS   A CD    1 
ATOM   218  C CE    . LYS   A 1 28  ? 46.169 -4.061  15.721 1    51.01  ?  207 LYS   A CE    1 
ATOM   219  N NZ    . LYS   A 1 28  ? 46.758 -4.108  14.356 1    53.89  ?  207 LYS   A NZ    1 
ATOM   220  N N     . TYR   A 1 29  ? 44.211 -9.61   19.171 1    35.76  ?  208 TYR   A N     1 
ATOM   221  C CA    . TYR   A 1 29  ? 44.572 -11.015 19.334 1    36.06  ?  208 TYR   A CA    1 
ATOM   222  C C     . TYR   A 1 29  ? 44.152 -11.759 18.086 1    37.76  ?  208 TYR   A C     1 
ATOM   223  O O     . TYR   A 1 29  ? 43.133 -11.431 17.469 1    37.67  ?  208 TYR   A O     1 
ATOM   224  C CB    . TYR   A 1 29  ? 44.059 -11.675 20.644 1    35.06  ?  208 TYR   A CB    1 
ATOM   225  C CG    . TYR   A 1 29  ? 42.574 -11.948 20.703 1    34.45  ?  208 TYR   A CG    1 
ATOM   226  C CD1   . TYR   A 1 29  ? 42.048 -13.156 20.256 1    34.76  ?  208 TYR   A CD1   1 
ATOM   227  C CD2   . TYR   A 1 29  ? 41.694 -11.001 21.203 1    35.02  ?  208 TYR   A CD2   1 
ATOM   228  C CE1   . TYR   A 1 29  ? 40.681 -13.397 20.266 1    35.33  ?  208 TYR   A CE1   1 
ATOM   229  C CE2   . TYR   A 1 29  ? 40.324 -11.24  21.244 1    35.86  ?  208 TYR   A CE2   1 
ATOM   230  C CZ    . TYR   A 1 29  ? 39.819 -12.437 20.766 1    36.95  ?  208 TYR   A CZ    1 
ATOM   231  O OH    . TYR   A 1 29  ? 38.46  -12.676 20.785 1    38.65  ?  208 TYR   A OH    1 
ATOM   232  N N     . THR   A 1 30  ? 44.942 -12.743 17.698 1    38.95  ?  209 THR   A N     1 
ATOM   233  C CA    . THR   A 1 30  ? 44.664 -13.528 16.501 1    40.71  ?  209 THR   A CA    1 
ATOM   234  C C     . THR   A 1 30  ? 44.16  -14.945 16.845 1    42.32  ?  209 THR   A C     1 
ATOM   235  O O     . THR   A 1 30  ? 44.18  -15.368 18.006 1    42.62  ?  209 THR   A O     1 
ATOM   236  C CB    . THR   A 1 30  ? 45.923 -13.555 15.629 1    42.01  ?  209 THR   A CB    1 
ATOM   237  O OG1   . THR   A 1 30  ? 46.955 -14.19  16.379 1    43.88  ?  209 THR   A OG1   1 
ATOM   238  C CG2   . THR   A 1 30  ? 46.366 -12.169 15.215 1    42.27  ?  209 THR   A CG2   1 
ATOM   239  N N     . THR   A 1 31  ? 43.658 -15.652 15.84  1    42.91  ?  210 THR   A N     1 
ATOM   240  C CA    . THR   A 1 31  ? 43.232 -17.028 15.981 1    44.26  ?  210 THR   A CA    1 
ATOM   241  C C     . THR   A 1 31  ? 43.865 -17.848 14.834 1    45.66  ?  210 THR   A C     1 
ATOM   242  O O     . THR   A 1 31  ? 44.162 -17.304 13.768 1    45.09  ?  210 THR   A O     1 
ATOM   243  C CB    . THR   A 1 31  ? 41.715 -17.101 16.034 1    45.83  ?  210 THR   A CB    1 
ATOM   244  O OG1   . THR   A 1 31  ? 41.321 -18.437 16.316 1    47.53  ?  210 THR   A OG1   1 
ATOM   245  C CG2   . THR   A 1 31  ? 41.06  -16.622 14.761 1    45.74  ?  210 THR   A CG2   1 
ATOM   246  N N     . ASN   A 1 32  ? 44.119 -19.136 15.068 1    47.22  ?  211 ASN   A N     1 
ATOM   247  C CA    . ASN   A 1 32  ? 44.706 -19.997 14.031 1    49.22  ?  211 ASN   A CA    1 
ATOM   248  C C     . ASN   A 1 32  ? 43.668 -20.627 13.086 1    51.07  ?  211 ASN   A C     1 
ATOM   249  O O     . ASN   A 1 32  ? 44.065 -21.246 12.109 1    51.89  ?  211 ASN   A O     1 
ATOM   250  C CB    . ASN   A 1 32  ? 45.585 -21.088 14.645 1    49.63  ?  211 ASN   A CB    1 
ATOM   251  C CG    . ASN   A 1 32  ? 46.836 -20.553 15.274 1    50.74  ?  211 ASN   A CG    1 
ATOM   252  O OD1   . ASN   A 1 32  ? 47.39  -19.524 14.858 1    51.08  ?  211 ASN   A OD1   1 
ATOM   253  N ND2   . ASN   A 1 32  ? 47.298 -21.241 16.298 1    51.15  ?  211 ASN   A ND2   1 
ATOM   254  N N     . ASN   A 1 33  ? 42.361 -20.477 13.38  1    51.93  ?  212 ASN   A N     1 
ATOM   255  C CA    . ASN   A 1 33  ? 41.253 -21.038 12.602 1    53.37  ?  212 ASN   A CA    1 
ATOM   256  C C     . ASN   A 1 33  ? 41.359 -20.663 11.139 1    54.14  ?  212 ASN   A C     1 
ATOM   257  O O     . ASN   A 1 33  ? 41.215 -19.482 10.82  1    54.05  ?  212 ASN   A O     1 
ATOM   258  C CB    . ASN   A 1 33  ? 39.903 -20.533 13.135 1    55.09  ?  212 ASN   A CB    1 
ATOM   259  C CG    . ASN   A 1 33  ? 39.568 -20.882 14.57  1    59.36  ?  212 ASN   A CG    1 
ATOM   260  O OD1   . ASN   A 1 33  ? 38.627 -20.329 15.147 1    61.06  ?  212 ASN   A OD1   1 
ATOM   261  N ND2   . ASN   A 1 33  ? 40.308 -21.795 15.187 1    60.11  ?  212 ASN   A ND2   1 
ATOM   262  N N     . SER   A 1 34  ? 41.651 -21.671 10.27  1    54.61  ?  213 SER   A N     1 
ATOM   263  C CA    . SER   A 1 34  ? 41.809 -21.603 8.809  1    55.5   ?  213 SER   A CA    1 
ATOM   264  C C     . SER   A 1 34  ? 42.39  -20.279 8.321  1    55.94  ?  213 SER   A C     1 
ATOM   265  O O     . SER   A 1 34  ? 41.85  -19.651 7.404  1    56.19  ?  213 SER   A O     1 
ATOM   266  C CB    . SER   A 1 34  ? 40.488 -21.911 8.107  1    57.45  ?  213 SER   A CB    1 
ATOM   267  O OG    . SER   A 1 34  ? 39.529 -20.897 8.37   1    60.07  ?  213 SER   A OG    1 
ATOM   268  N N     . SER   A 1 35  ? 43.462 -19.823 8.977  1    55.49  ?  214 SER   A N     1 
ATOM   269  C CA    . SER   A 1 35  ? 44.064 -18.542 8.653  1    55.8   ?  214 SER   A CA    1 
ATOM   270  C C     . SER   A 1 35  ? 44.749 -18.501 7.302  1    56.58  ?  214 SER   A C     1 
ATOM   271  O O     . SER   A 1 35  ? 44.967 -17.415 6.754  1    56.62  ?  214 SER   A O     1 
ATOM   272  C CB    . SER   A 1 35  ? 45.038 -18.123 9.75   1    57.01  ?  214 SER   A CB    1 
ATOM   273  O OG    . SER   A 1 35  ? 45.944 -19.166 10.07  1    58.93  ?  214 SER   A OG    1 
ATOM   274  N N     . GLU   A 1 36  ? 45.129 -19.67  6.768  1    57     ?  215 GLU   A N     1 
ATOM   275  C CA    . GLU   A 1 36  ? 45.855 -19.723 5.508  1    57.3   ?  215 GLU   A CA    1 
ATOM   276  C C     . GLU   A 1 36  ? 45.074 -20.342 4.378  1    57.32  ?  215 GLU   A C     1 
ATOM   277  O O     . GLU   A 1 36  ? 45.365 -20.031 3.225  1    57.65  ?  215 GLU   A O     1 
ATOM   278  C CB    . GLU   A 1 36  ? 47.201 -20.423 5.687  1    58.82  ?  215 GLU   A CB    1 
ATOM   279  C CG    . GLU   A 1 36  ? 48.019 -19.822 6.811  1    61.66  ?  215 GLU   A CG    1 
ATOM   280  C CD    . GLU   A 1 36  ? 49.223 -19.027 6.36   1    65.1   ?  215 GLU   A CD    1 
ATOM   281  O OE1   . GLU   A 1 36  ? 49.662 -19.211 5.202  1    65.31  ?  215 GLU   A OE1   1 
ATOM   282  O OE2   . GLU   A 1 36  ? 49.772 -18.267 7.191  1    67.07  ?  215 GLU   A OE2   1 
ATOM   283  N N     . GLN   A 1 37  ? 44.102 -21.208 4.68   1    57.06  ?  216 GLN   A N     1 
ATOM   284  C CA    . GLN   A 1 37  ? 43.321 -21.831 3.621  1    57.67  ?  216 GLN   A CA    1 
ATOM   285  C C     . GLN   A 1 37  ? 41.919 -21.222 3.494  1    57.82  ?  216 GLN   A C     1 
ATOM   286  O O     . GLN   A 1 37  ? 41.231 -20.996 4.494  1    57.92  ?  216 GLN   A O     1 
ATOM   287  C CB    . GLN   A 1 37  ? 43.287 -23.369 3.749  1    59.55  ?  216 GLN   A CB    1 
ATOM   288  C CG    . GLN   A 1 37  ? 42.24  -23.948 4.693  1    63.56  ?  216 GLN   A CG    1 
ATOM   289  C CD    . GLN   A 1 37  ? 42.236 -25.46  4.632  1    70.06  ?  216 GLN   A CD    1 
ATOM   290  O OE1   . GLN   A 1 37  ? 41.226 -26.098 4.288  1    72.07  ?  216 GLN   A OE1   1 
ATOM   291  N NE2   . GLN   A 1 37  ? 43.372 -26.075 4.955  1    71.02  ?  216 GLN   A NE2   1 
ATOM   292  N N     . ARG   A 1 38  ? 41.518 -20.92  2.256  1    57.31  ?  217 ARG   A N     1 
ATOM   293  C CA    . ARG   A 1 38  ? 40.189 -20.4   1.989  1    57.12  ?  217 ARG   A CA    1 
ATOM   294  C C     . ARG   A 1 38  ? 39.208 -21.558 1.926  1    56.52  ?  217 ARG   A C     1 
ATOM   295  O O     . ARG   A 1 38  ? 39.45  -22.549 1.256  1    56.37  ?  217 ARG   A O     1 
ATOM   296  C CB    . ARG   A 1 38  ? 40.148 -19.567 0.701  1    58.23  ?  217 ARG   A CB    1 
ATOM   297  C CG    . ARG   A 1 38  ? 39.937 -18.09  0.996  1    61.75  ?  217 ARG   A CG    1 
ATOM   298  C CD    . ARG   A 1 38  ? 39.959 -17.219 -0.241 1    65.35  ?  217 ARG   A CD    1 
ATOM   299  N NE    . ARG   A 1 38  ? 40.246 -15.818 0.084  1    68.16  ?  217 ARG   A NE    1 
ATOM   300  C CZ    . ARG   A 1 38  ? 39.584 -14.78  -0.421 1    71.13  ?  217 ARG   A CZ    1 
ATOM   301  N NH1   . ARG   A 1 38  ? 38.581 -14.971 -1.271 1    71.2   ?  217 ARG   A NH1   1 
ATOM   302  N NH2   . ARG   A 1 38  ? 39.918 -13.541 -0.079 1    71.07  ?  217 ARG   A NH2   1 
ATOM   303  N N     . VAL   A 1 39  ? 38.164 -21.478 2.718  1    56.25  ?  218 VAL   A N     1 
ATOM   304  C CA    . VAL   A 1 39  ? 37.089 -22.462 2.759  1    56.96  ?  218 VAL   A CA    1 
ATOM   305  C C     . VAL   A 1 39  ? 35.746 -21.733 2.566  1    57.56  ?  218 VAL   A C     1 
ATOM   306  O O     . VAL   A 1 39  ? 35.698 -20.5   2.606  1    57.68  ?  218 VAL   A O     1 
ATOM   307  C CB    . VAL   A 1 39  ? 37.112 -23.328 4.042  1    57.74  ?  218 VAL   A CB    1 
ATOM   308  C CG1   . VAL   A 1 39  ? 38.484 -23.976 4.241  1    58.49  ?  218 VAL   A CG1   1 
ATOM   309  C CG2   . VAL   A 1 39  ? 36.7   -22.511 5.266  1    58.21  ?  218 VAL   A CG2   1 
ATOM   310  N N     . SER   A 1 40  ? 34.668 -22.479 2.304  1    57.83  ?  219 SER   A N     1 
ATOM   311  C CA    . SER   A 1 40  ? 33.355 -21.88  2.102  1    58.32  ?  219 SER   A CA    1 
ATOM   312  C C     . SER   A 1 40  ? 32.881 -21.24  3.401  1    58.47  ?  219 SER   A C     1 
ATOM   313  O O     . SER   A 1 40  ? 32.345 -20.13  3.372  1    58.4   ?  219 SER   A O     1 
ATOM   314  C CB    . SER   A 1 40  ? 32.357 -22.934 1.631  1    59.99  ?  219 SER   A CB    1 
ATOM   315  O OG    . SER   A 1 40  ? 32.219 -23.958 2.605  1    62.74  ?  219 SER   A OG    1 
ATOM   316  N N     . LEU   A 1 41  ? 33.117 -21.924 4.542  1    58.45  ?  220 LEU   A N     1 
ATOM   317  C CA    . LEU   A 1 41  ? 32.724 -21.435 5.856  1    58.61  ?  220 LEU   A CA    1 
ATOM   318  C C     . LEU   A 1 41  ? 33.431 -22.164 7.013  1    58.84  ?  220 LEU   A C     1 
ATOM   319  O O     . LEU   A 1 41  ? 33.256 -23.368 7.179  1    59.44  ?  220 LEU   A O     1 
ATOM   320  C CB    . LEU   A 1 41  ? 31.207 -21.581 6.024  1    58.51  ?  220 LEU   A CB    1 
ATOM   321  C CG    . LEU   A 1 41  ? 30.629 -20.929 7.268  1    59.52  ?  220 LEU   A CG    1 
ATOM   322  C CD1   . LEU   A 1 41  ? 30.453 -19.439 7.067  1    59.69  ?  220 LEU   A CD1   1 
ATOM   323  C CD2   . LEU   A 1 41  ? 29.329 -21.592 7.679  1    60.09  ?  220 LEU   A CD2   1 
ATOM   324  N N     . ASP   A 1 42  ? 34.171 -21.424 7.856  1    58     ?  221 ASP   A N     1 
ATOM   325  C CA    . ASP   A 1 42  ? 34.797 -21.993 9.046  1    57.37  ?  221 ASP   A CA    1 
ATOM   326  C C     . ASP   A 1 42  ? 33.783 -21.833 10.186 1    56.66  ?  221 ASP   A C     1 
ATOM   327  O O     . ASP   A 1 42  ? 33.423 -20.708 10.532 1    56.5   ?  221 ASP   A O     1 
ATOM   328  C CB    . ASP   A 1 42  ? 36.11  -21.271 9.371  1    58.84  ?  221 ASP   A CB    1 
ATOM   329  C CG    . ASP   A 1 42  ? 36.933 -21.921 10.473 1    63.39  ?  221 ASP   A CG    1 
ATOM   330  O OD1   . ASP   A 1 42  ? 36.338 -22.417 11.45  1    63.93  ?  221 ASP   A OD1   1 
ATOM   331  O OD2   . ASP   A 1 42  ? 38.173 -21.926 10.36  1    65.92  ?  221 ASP   A OD2   1 
ATOM   332  N N     . ILE   A 1 43  ? 33.303 -22.957 10.74  1    55.83  ?  222 ILE   A N     1 
ATOM   333  C CA    . ILE   A 1 43  ? 32.29  -22.951 11.787 1    55.91  ?  222 ILE   A CA    1 
ATOM   334  C C     . ILE   A 1 43  ? 32.729 -22.18  13.043 1    55.21  ?  222 ILE   A C     1 
ATOM   335  O O     . ILE   A 1 43  ? 31.945 -21.388 13.571 1    55.23  ?  222 ILE   A O     1 
ATOM   336  C CB    . ILE   A 1 43  ? 31.815 -24.395 12.113 1    56.9   ?  222 ILE   A CB    1 
ATOM   337  C CG1   . ILE   A 1 43  ? 30.756 -24.411 13.225 1    58.1   ?  222 ILE   A CG1   1 
ATOM   338  C CG2   . ILE   A 1 43  ? 32.992 -25.321 12.448 1    57.69  ?  222 ILE   A CG2   1 
ATOM   339  C CD1   . ILE   A 1 43  ? 29.438 -23.766 12.823 1    59.62  ?  222 ILE   A CD1   1 
ATOM   340  N N     . ASP   A 1 44  ? 33.967 -22.393 13.506 1    53.97  ?  223 ASP   A N     1 
ATOM   341  C CA    . ASP   A 1 44  ? 34.454 -21.709 14.696 1    53.2   ?  223 ASP   A CA    1 
ATOM   342  C C     . ASP   A 1 44  ? 34.584 -20.211 14.475 1    50.81  ?  223 ASP   A C     1 
ATOM   343  O O     . ASP   A 1 44  ? 34.308 -19.439 15.388 1    51.1   ?  223 ASP   A O     1 
ATOM   344  C CB    . ASP   A 1 44  ? 35.751 -22.346 15.207 1    56.55  ?  223 ASP   A CB    1 
ATOM   345  C CG    . ASP   A 1 44  ? 35.552 -23.791 15.647 1    63.05  ?  223 ASP   A CG    1 
ATOM   346  O OD1   . ASP   A 1 44  ? 34.441 -24.119 16.137 1    64.16  ?  223 ASP   A OD1   1 
ATOM   347  O OD2   . ASP   A 1 44  ? 36.497 -24.595 15.488 1    65.68  ?  223 ASP   A OD2   1 
ATOM   348  N N     . LEU   A 1 45  ? 34.926 -19.795 13.255 1    48.47  ?  224 LEU   A N     1 
ATOM   349  C CA    . LEU   A 1 45  ? 35.008 -18.379 12.925 1    47.19  ?  224 LEU   A CA    1 
ATOM   350  C C     . LEU   A 1 45  ? 33.589 -17.796 12.879 1    45.27  ?  224 LEU   A C     1 
ATOM   351  O O     . LEU   A 1 45  ? 33.346 -16.759 13.477 1    44.71  ?  224 LEU   A O     1 
ATOM   352  C CB    . LEU   A 1 45  ? 35.742 -18.164 11.591 1    47.36  ?  224 LEU   A CB    1 
ATOM   353  C CG    . LEU   A 1 45  ? 37.248 -18.281 11.643 1    48.75  ?  224 LEU   A CG    1 
ATOM   354  C CD1   . LEU   A 1 45  ? 37.822 -18.173 10.271 1    49.78  ?  224 LEU   A CD1   1 
ATOM   355  C CD2   . LEU   A 1 45  ? 37.842 -17.192 12.504 1    49.26  ?  224 LEU   A CD2   1 
ATOM   356  N N     . TRP   A 1 46  ? 32.659 -18.484 12.208 1    44.25  ?  225 TRP   A N     1 
ATOM   357  C CA    . TRP   A 1 46  ? 31.255 -18.085 12.132 1    43.86  ?  225 TRP   A CA    1 
ATOM   358  C C     . TRP   A 1 46  ? 30.619 -17.859 13.521 1    43.18  ?  225 TRP   A C     1 
ATOM   359  O O     . TRP   A 1 46  ? 29.927 -16.879 13.679 1    42.73  ?  225 TRP   A O     1 
ATOM   360  C CB    . TRP   A 1 46  ? 30.406 -19.075 11.282 1    43.54  ?  225 TRP   A CB    1 
ATOM   361  C CG    . TRP   A 1 46  ? 28.927 -18.881 11.467 1    43.45  ?  225 TRP   A CG    1 
ATOM   362  C CD1   . TRP   A 1 46  ? 28.1   -19.625 12.256 1    44.17  ?  225 TRP   A CD1   1 
ATOM   363  C CD2   . TRP   A 1 46  ? 28.165 -17.736 11.055 1    43.49  ?  225 TRP   A CD2   1 
ATOM   364  N NE1   . TRP   A 1 46  ? 26.844 -19.059 12.293 1    44.54  ?  225 TRP   A NE1   1 
ATOM   365  C CE2   . TRP   A 1 46  ? 26.858 -17.896 11.566 1    44.31  ?  225 TRP   A CE2   1 
ATOM   366  C CE3   . TRP   A 1 46  ? 28.449 -16.608 10.27  1    44     ?  225 TRP   A CE3   1 
ATOM   367  C CZ2   . TRP   A 1 46  ? 25.843 -16.968 11.323 1    44.75  ?  225 TRP   A CZ2   1 
ATOM   368  C CZ3   . TRP   A 1 46  ? 27.437 -15.694 10.023 1    44.83  ?  225 TRP   A CZ3   1 
ATOM   369  C CH2   . TRP   A 1 46  ? 26.15  -15.885 10.537 1    44.76  ?  225 TRP   A CH2   1 
ATOM   370  N N     . ASP   A 1 47  ? 30.822 -18.753 14.502 1    43.3   ?  226 ASP   A N     1 
ATOM   371  C CA    . ASP   A 1 47  ? 30.251 -18.579 15.841 1    44.02  ?  226 ASP   A CA    1 
ATOM   372  C C     . ASP   A 1 47  ? 30.784 -17.322 16.535 1    42.32  ?  226 ASP   A C     1 
ATOM   373  O O     . ASP   A 1 47  ? 30.033 -16.657 17.261 1    42.42  ?  226 ASP   A O     1 
ATOM   374  C CB    . ASP   A 1 47  ? 30.552 -19.795 16.733 1    48.75  ?  226 ASP   A CB    1 
ATOM   375  C CG    . ASP   A 1 47  ? 30.042 -21.099 16.161 1    57.95  ?  226 ASP   A CG    1 
ATOM   376  O OD1   . ASP   A 1 47  ? 28.865 -21.135 15.717 1    58.51  ?  226 ASP   A OD1   1 
ATOM   377  O OD2   . ASP   A 1 47  ? 30.827 -22.082 16.134 1    62.32  ?  226 ASP   A OD2   1 
ATOM   378  N N     . LYS   A 1 48  ? 32.088 -17.035 16.36  1    40.16  ?  227 LYS   A N     1 
ATOM   379  C CA    . LYS   A 1 48  ? 32.696 -15.85  16.948 1    38.8   ?  227 LYS   A CA    1 
ATOM   380  C C     . LYS   A 1 48  ? 32.201 -14.589 16.241 1    36.55  ?  227 LYS   A C     1 
ATOM   381  O O     . LYS   A 1 48  ? 31.861 -13.607 16.898 1    36.14  ?  227 LYS   A O     1 
ATOM   382  C CB    . LYS   A 1 48  ? 34.229 -15.918 16.877 1    41.2   ?  227 LYS   A CB    1 
ATOM   383  C CG    . LYS   A 1 48  ? 34.857 -16.746 17.981 1    45.9   ?  227 LYS   A CG    1 
ATOM   384  C CD    . LYS   A 1 48  ? 36.34  -16.948 17.722 1    51.48  ?  227 LYS   A CD    1 
ATOM   385  C CE    . LYS   A 1 48  ? 37.002 -17.811 18.767 1    55.18  ?  227 LYS   A CE    1 
ATOM   386  N NZ    . LYS   A 1 48  ? 38.258 -18.399 18.237 1    57.92  ?  227 LYS   A NZ    1 
ATOM   387  N N     . PHE   A 1 49  ? 32.102 -14.644 14.916 1    34.68  ?  228 PHE   A N     1 
ATOM   388  C CA    . PHE   A 1 49  ? 31.697 -13.516 14.118 1    34.52  ?  228 PHE   A CA    1 
ATOM   389  C C     . PHE   A 1 49  ? 30.208 -13.195 14.276 1    34.58  ?  228 PHE   A C     1 
ATOM   390  O O     . PHE   A 1 49  ? 29.835 -12.027 14.302 1    34.16  ?  228 PHE   A O     1 
ATOM   391  C CB    . PHE   A 1 49  ? 32.11  -13.752 12.673 1    34.44  ?  228 PHE   A CB    1 
ATOM   392  C CG    . PHE   A 1 49  ? 31.528 -12.84  11.627 1    35.25  ?  228 PHE   A CG    1 
ATOM   393  C CD1   . PHE   A 1 49  ? 31.812 -11.49  11.628 1    35.73  ?  228 PHE   A CD1   1 
ATOM   394  C CD2   . PHE   A 1 49  ? 30.749 -13.346 10.607 1    35.99  ?  228 PHE   A CD2   1 
ATOM   395  C CE1   . PHE   A 1 49  ? 31.303 -10.662 10.648 1    36.37  ?  228 PHE   A CE1   1 
ATOM   396  C CE2   . PHE   A 1 49  ? 30.249 -12.516 9.623  1    36.79  ?  228 PHE   A CE2   1 
ATOM   397  C CZ    . PHE   A 1 49  ? 30.537 -11.183 9.643  1    36.56  ?  228 PHE   A CZ    1 
ATOM   398  N N     . SER   A 1 50  ? 29.383 -14.215 14.422 1    34.98  ?  229 SER   A N     1 
ATOM   399  C CA    . SER   A 1 50  ? 27.946 -14.053 14.6   1    36.13  ?  229 SER   A CA    1 
ATOM   400  C C     . SER   A 1 50  ? 27.65  -13.485 15.977 1    36.24  ?  229 SER   A C     1 
ATOM   401  O O     . SER   A 1 50  ? 26.811 -12.597 16.097 1    36.44  ?  229 SER   A O     1 
ATOM   402  C CB    . SER   A 1 50  ? 27.222 -15.382 14.396 1    38.13  ?  229 SER   A CB    1 
ATOM   403  O OG    . SER   A 1 50  ? 27.583 -16.331 15.387 1    40.07  ?  229 SER   A OG    1 
ATOM   404  N N     . GLU   A 1 51  ? 28.385 -13.93  17.004 1    36.16  ?  230 GLU   A N     1 
ATOM   405  C CA    . GLU   A 1 51  ? 28.217 -13.409 18.354 1    36.35  ?  230 GLU   A CA    1 
ATOM   406  C C     . GLU   A 1 51  ? 28.709 -11.954 18.437 1    34.94  ?  230 GLU   A C     1 
ATOM   407  O O     . GLU   A 1 51  ? 28.065 -11.124 19.089 1    35.52  ?  230 GLU   A O     1 
ATOM   408  C CB    . GLU   A 1 51  ? 28.953 -14.288 19.377 1    40.51  ?  230 GLU   A CB    1 
ATOM   409  C CG    . GLU   A 1 51  ? 29.021 -13.696 20.776 1    50.39  ?  230 GLU   A CG    1 
ATOM   410  C CD    . GLU   A 1 51  ? 27.718 -13.641 21.555 1    65.07  ?  230 GLU   A CD    1 
ATOM   411  O OE1   . GLU   A 1 51  ? 27.474 -14.587 22.339 1    68.76  ?  230 GLU   A OE1   1 
ATOM   412  O OE2   . GLU   A 1 51  ? 26.955 -12.653 21.405 1    69.06  ?  230 GLU   A OE2   1 
ATOM   413  N N     . LEU   A 1 52  ? 29.834 -11.649 17.788 1    32.6   ?  231 LEU   A N     1 
ATOM   414  C CA    . LEU   A 1 52  ? 30.349 -10.279 17.784 1    30.89  ?  231 LEU   A CA    1 
ATOM   415  C C     . LEU   A 1 52  ? 29.396 -9.335  17.051 1    30.37  ?  231 LEU   A C     1 
ATOM   416  O O     . LEU   A 1 52  ? 29.25  -8.195  17.469 1    31.01  ?  231 LEU   A O     1 
ATOM   417  C CB    . LEU   A 1 52  ? 31.735 -10.217 17.157 1    29.8   ?  231 LEU   A CB    1 
ATOM   418  C CG    . LEU   A 1 52  ? 32.865 -10.681 18.069 1    29.62  ?  231 LEU   A CG    1 
ATOM   419  C CD1   . LEU   A 1 52  ? 34.076 -11.064 17.249 1    29.96  ?  231 LEU   A CD1   1 
ATOM   420  C CD2   . LEU   A 1 52  ? 33.217 -9.603  19.103 1    29.22  ?  231 LEU   A CD2   1 
ATOM   421  N N     . SER   A 1 53  ? 28.729 -9.812  15.991 1    29.07  ?  232 SER   A N     1 
ATOM   422  C CA    . SER   A 1 53  ? 27.781 -9.011  15.221 1    29.9   ?  232 SER   A CA    1 
ATOM   423  C C     . SER   A 1 53  ? 26.547 -8.72   16.069 1    30.8   ?  232 SER   A C     1 
ATOM   424  O O     . SER   A 1 53  ? 26.038 -7.6    16.017 1    31     ?  232 SER   A O     1 
ATOM   425  C CB    . SER   A 1 53  ? 27.374 -9.713  13.917 1    29.97  ?  232 SER   A CB    1 
ATOM   426  O OG    . SER   A 1 53  ? 28.497 -10.02  13.106 1    31.02  ?  232 SER   A OG    1 
ATOM   427  N N     . THR   A 1 54  ? 26.078 -9.717  16.849 1    30.78  ?  233 THR   A N     1 
ATOM   428  C CA    . THR   A 1 54  ? 24.961 -9.561  17.756 1    32.71  ?  233 THR   A CA    1 
ATOM   429  C C     . THR   A 1 54  ? 25.227 -8.445  18.78  1    33.32  ?  233 THR   A C     1 
ATOM   430  O O     . THR   A 1 54  ? 24.391 -7.546  18.965 1    33.86  ?  233 THR   A O     1 
ATOM   431  C CB    . THR   A 1 54  ? 24.636 -10.904 18.396 1    35.69  ?  233 THR   A CB    1 
ATOM   432  O OG1   . THR   A 1 54  ? 24.149 -11.773 17.348 1    38.19  ?  233 THR   A OG1   1 
ATOM   433  C CG2   . THR   A 1 54  ? 23.618 -10.784 19.526 1    35.38  ?  233 THR   A CG2   1 
ATOM   434  N N     . LYS   A 1 55  ? 26.411 -8.451  19.373 1    32.84  ?  234 LYS   A N     1 
ATOM   435  C CA    . LYS   A 1 55  ? 26.823 -7.418  20.321 1    33.09  ?  234 LYS   A CA    1 
ATOM   436  C C     . LYS   A 1 55  ? 26.901 -6.059  19.62  1    32.84  ?  234 LYS   A C     1 
ATOM   437  O O     . LYS   A 1 55  ? 26.531 -5.046  20.211 1    32.69  ?  234 LYS   A O     1 
ATOM   438  C CB    . LYS   A 1 55  ? 28.214 -7.729  20.878 1    35.29  ?  234 LYS   A CB    1 
ATOM   439  C CG    . LYS   A 1 55  ? 28.307 -8.923  21.794 1    40.07  ?  234 LYS   A CG    1 
ATOM   440  C CD    . LYS   A 1 55  ? 29.766 -9.106  22.188 1    45.71  ?  234 LYS   A CD    1 
ATOM   441  C CE    . LYS   A 1 55  ? 29.93  -9.909  23.446 1    50.03  ?  234 LYS   A CE    1 
ATOM   442  N NZ    . LYS   A 1 55  ? 28.956 -11.029 23.491 1    52.89  ?  234 LYS   A NZ    1 
ATOM   443  N N     . CYS   A 1 56  ? 27.405 -6.03   18.379 1    32.5   ?  235 CYS   A N     1 
ATOM   444  C CA    . CYS   A 1 56  ? 27.518 -4.79   17.635 1    32.97  ?  235 CYS   A CA    1 
ATOM   445  C C     . CYS   A 1 56  ? 26.145 -4.228  17.235 1    32.15  ?  235 CYS   A C     1 
ATOM   446  O O     . CYS   A 1 56  ? 25.962 -3.018  17.252 1    31.67  ?  235 CYS   A O     1 
ATOM   447  C CB    . CYS   A 1 56  ? 28.46  -4.934  16.446 1    34.41  ?  235 CYS   A CB    1 
ATOM   448  S SG    . CYS   A 1 56  ? 28.768 -3.379  15.563 1    42.07  ?  235 CYS   A SG    1 
ATOM   449  N N     . ILE   A 1 57  ? 25.16  -5.099  16.985 1    31.91  ?  236 ILE   A N     1 
ATOM   450  C CA    . ILE   A 1 57  ? 23.777 -4.662  16.724 1    32.18  ?  236 ILE   A CA    1 
ATOM   451  C C     . ILE   A 1 57  ? 23.219 -3.961  17.963 1    31.76  ?  236 ILE   A C     1 
ATOM   452  O O     . ILE   A 1 57  ? 22.681 -2.851  17.863 1    32.67  ?  236 ILE   A O     1 
ATOM   453  C CB    . ILE   A 1 57  ? 22.871 -5.823  16.258 1    32.84  ?  236 ILE   A CB    1 
ATOM   454  C CG1   . ILE   A 1 57  ? 23.328 -6.331  14.881 1    33.67  ?  236 ILE   A CG1   1 
ATOM   455  C CG2   . ILE   A 1 57  ? 21.39  -5.382  16.208 1    32.97  ?  236 ILE   A CG2   1 
ATOM   456  C CD1   . ILE   A 1 57  ? 22.684 -7.63   14.505 1    35.31  ?  236 ILE   A CD1   1 
ATOM   457  N N     . ILE   A 1 58  ? 23.476 -4.523  19.144 1    30.66  ?  237 ILE   A N     1 
ATOM   458  C CA    . ILE   A 1 58  ? 23.054 -3.905  20.389 1    30.64  ?  237 ILE   A CA    1 
ATOM   459  C C     . ILE   A 1 58  ? 23.682 -2.5    20.549 1    30.54  ?  237 ILE   A C     1 
ATOM   460  O O     . ILE   A 1 58  ? 22.969 -1.532  20.827 1    30.95  ?  237 ILE   A O     1 
ATOM   461  C CB    . ILE   A 1 58  ? 23.295 -4.85   21.6   1    31.26  ?  237 ILE   A CB    1 
ATOM   462  C CG1   . ILE   A 1 58  ? 22.473 -6.171  21.434 1    32.43  ?  237 ILE   A CG1   1 
ATOM   463  C CG2   . ILE   A 1 58  ? 22.948 -4.152  22.921 1    31.23  ?  237 ILE   A CG2   1 
ATOM   464  C CD1   . ILE   A 1 58  ? 22.842 -7.309  22.505 1    33.22  ?  237 ILE   A CD1   1 
ATOM   465  N N     . LYS   A 1 59  ? 24.981 -2.376  20.284 1    29.46  ?  238 LYS   A N     1 
ATOM   466  C CA    . LYS   A 1 59  ? 25.64  -1.083  20.34  1    29.3   ?  238 LYS   A CA    1 
ATOM   467  C C     . LYS   A 1 59  ? 25.055 -0.075  19.296 1    29.86  ?  238 LYS   A C     1 
ATOM   468  O O     . LYS   A 1 59  ? 24.907 1.101   19.613 1    30.5   ?  238 LYS   A O     1 
ATOM   469  C CB    . LYS   A 1 59  ? 27.149 -1.262  20.154 1    30.19  ?  238 LYS   A CB    1 
ATOM   470  C CG    . LYS   A 1 59  ? 27.796 -1.943  21.325 1    32.05  ?  238 LYS   A CG    1 
ATOM   471  C CD    . LYS   A 1 59  ? 27.974 -0.954  22.454 1    35.06  ?  238 LYS   A CD    1 
ATOM   472  C CE    . LYS   A 1 59  ? 28.775 -1.582  23.547 1    38.89  ?  238 LYS   A CE    1 
ATOM   473  N NZ    . LYS   A 1 59  ? 28.116 -1.438  24.853 1    41.82  ?  238 LYS   A NZ    1 
ATOM   474  N N     . THR   A 1 60  ? 24.751 -0.52   18.078 1    29.21  ?  239 THR   A N     1 
ATOM   475  C CA    . THR   A 1 60  ? 24.175 0.343   17.053 1    30.41  ?  239 THR   A CA    1 
ATOM   476  C C     . THR   A 1 60  ? 22.8   0.873   17.473 1    31.63  ?  239 THR   A C     1 
ATOM   477  O O     . THR   A 1 60  ? 22.519 2.053   17.253 1    31.62  ?  239 THR   A O     1 
ATOM   478  C CB    . THR   A 1 60  ? 24.078 -0.381  15.722 1    31.81  ?  239 THR   A CB    1 
ATOM   479  O OG1   . THR   A 1 60  ? 25.396 -0.677  15.304 1    32.86  ?  239 THR   A OG1   1 
ATOM   480  C CG2   . THR   A 1 60  ? 23.415 0.478   14.657 1    32.42  ?  239 THR   A CG2   1 
ATOM   481  N N     . VAL   A 1 61  ? 21.963 0.02    18.111 1    32.38  ?  240 VAL   A N     1 
ATOM   482  C CA    . VAL   A 1 61  ? 20.672 0.458   18.668 1    33.77  ?  240 VAL   A CA    1 
ATOM   483  C C     . VAL   A 1 61  ? 20.916 1.525   19.8   1    34.84  ?  240 VAL   A C     1 
ATOM   484  O O     . VAL   A 1 61  ? 20.267 2.569   19.784 1    35.05  ?  240 VAL   A O     1 
ATOM   485  C CB    . VAL   A 1 61  ? 19.792 -0.716  19.183 1    34.56  ?  240 VAL   A CB    1 
ATOM   486  C CG1   . VAL   A 1 61  ? 18.529 -0.192  19.864 1    34.93  ?  240 VAL   A CG1   1 
ATOM   487  C CG2   . VAL   A 1 61  ? 19.43  -1.678  18.057 1    35.01  ?  240 VAL   A CG2   1 
ATOM   488  N N     . GLU   A 1 62  ? 21.911 1.313   20.698 1    34.9   ?  241 GLU   A N     1 
ATOM   489  C CA    . GLU   A 1 62  ? 22.262 2.29    21.748 1    35.92  ?  241 GLU   A CA    1 
ATOM   490  C C     . GLU   A 1 62  ? 22.698 3.631   21.123 1    36.19  ?  241 GLU   A C     1 
ATOM   491  O O     . GLU   A 1 62  ? 22.382 4.711   21.65  1    36.68  ?  241 GLU   A O     1 
ATOM   492  C CB    . GLU   A 1 62  ? 23.429 1.794   22.633 1    39.02  ?  241 GLU   A CB    1 
ATOM   493  C CG    . GLU   A 1 62  ? 23.168 0.594   23.521 1    48.22  ?  241 GLU   A CG    1 
ATOM   494  C CD    . GLU   A 1 62  ? 24.406 0.205   24.322 1    59.23  ?  241 GLU   A CD    1 
ATOM   495  O OE1   . GLU   A 1 62  ? 25.028 1.112   24.925 1    61.72  ?  241 GLU   A OE1   1 
ATOM   496  O OE2   . GLU   A 1 62  ? 24.769 -0.996  24.33  1    60.87  ?  241 GLU   A OE2   1 
ATOM   497  N N     . PHE   A 1 63  ? 23.475 3.549   20.041 1    35.58  ?  242 PHE   A N     1 
ATOM   498  C CA    . PHE   A 1 63  ? 23.953 4.707   19.291 1    35.74  ?  242 PHE   A CA    1 
ATOM   499  C C     . PHE   A 1 63  ? 22.746 5.479   18.719 1    36.43  ?  242 PHE   A C     1 
ATOM   500  O O     . PHE   A 1 63  ? 22.67  6.693   18.893 1    37.03  ?  242 PHE   A O     1 
ATOM   501  C CB    . PHE   A 1 63  ? 24.914 4.255   18.169 1    34.99  ?  242 PHE   A CB    1 
ATOM   502  C CG    . PHE   A 1 63  ? 25.257 5.314   17.152 1    34.68  ?  242 PHE   A CG    1 
ATOM   503  C CD1   . PHE   A 1 63  ? 26.128 6.341   17.464 1    35.11  ?  242 PHE   A CD1   1 
ATOM   504  C CD2   . PHE   A 1 63  ? 24.727 5.268   15.875 1    34.91  ?  242 PHE   A CD2   1 
ATOM   505  C CE1   . PHE   A 1 63  ? 26.438 7.323   16.524 1    35.59  ?  242 PHE   A CE1   1 
ATOM   506  C CE2   . PHE   A 1 63  ? 25.015 6.263   14.953 1    35.51  ?  242 PHE   A CE2   1 
ATOM   507  C CZ    . PHE   A 1 63  ? 25.9   7.265   15.272 1    35.02  ?  242 PHE   A CZ    1 
ATOM   508  N N     . ALA   A 1 64  ? 21.799 4.765   18.078 1    35.99  ?  243 ALA   A N     1 
ATOM   509  C CA    . ALA   A 1 64  ? 20.6   5.346   17.485 1    36.62  ?  243 ALA   A CA    1 
ATOM   510  C C     . ALA   A 1 64  ? 19.735 6.094   18.508 1    37.41  ?  243 ALA   A C     1 
ATOM   511  O O     . ALA   A 1 64  ? 19.29  7.206   18.237 1    37.15  ?  243 ALA   A O     1 
ATOM   512  C CB    . ALA   A 1 64  ? 19.782 4.267   16.796 1    36.36  ?  243 ALA   A CB    1 
ATOM   513  N N     . LYS   A 1 65  ? 19.557 5.518   19.696 1    37.91  ?  244 LYS   A N     1 
ATOM   514  C CA    . LYS   A 1 65  ? 18.778 6.141   20.771 1    39.17  ?  244 LYS   A CA    1 
ATOM   515  C C     . LYS   A 1 65  ? 19.379 7.439   21.296 1    40.7   ?  244 LYS   A C     1 
ATOM   516  O O     . LYS   A 1 65  ? 18.658 8.237   21.892 1    41.06  ?  244 LYS   A O     1 
ATOM   517  C CB    . LYS   A 1 65  ? 18.544 5.157   21.923 1    40.51  ?  244 LYS   A CB    1 
ATOM   518  C CG    . LYS   A 1 65  ? 17.759 3.937   21.489 1    44.17  ?  244 LYS   A CG    1 
ATOM   519  C CD    . LYS   A 1 65  ? 16.848 3.442   22.589 1    49.6   ?  244 LYS   A CD    1 
ATOM   520  C CE    . LYS   A 1 65  ? 17.574 2.943   23.802 1    53.72  ?  244 LYS   A CE    1 
ATOM   521  N NZ    . LYS   A 1 65  ? 16.625 2.419   24.819 1    56.14  ?  244 LYS   A NZ    1 
ATOM   522  N N     . GLN   A 1 66  ? 20.683 7.672   21.064 1    41.16  ?  245 GLN   A N     1 
ATOM   523  C CA    . GLN   A 1 66  ? 21.338 8.903   21.48  1    42.01  ?  245 GLN   A CA    1 
ATOM   524  C C     . GLN   A 1 66  ? 21.319 9.996   20.398 1    43.2   ?  245 GLN   A C     1 
ATOM   525  O O     . GLN   A 1 66  ? 21.696 11.137  20.688 1    43.78  ?  245 GLN   A O     1 
ATOM   526  C CB    . GLN   A 1 66  ? 22.78  8.626   21.911 1    43.59  ?  245 GLN   A CB    1 
ATOM   527  C CG    . GLN   A 1 66  ? 22.876 7.702   23.108 1    49.43  ?  245 GLN   A CG    1 
ATOM   528  C CD    . GLN   A 1 66  ? 24.314 7.29    23.375 1    57.77  ?  245 GLN   A CD    1 
ATOM   529  O OE1   . GLN   A 1 66  ? 24.688 6.113   23.226 1    59.73  ?  245 GLN   A OE1   1 
ATOM   530  N NE2   . GLN   A 1 66  ? 25.161 8.252   23.761 1    58.7   ?  245 GLN   A NE2   1 
ATOM   531  N N     . LEU   A 1 67  ? 20.942 9.651   19.144 1    43.25  ?  246 LEU   A N     1 
ATOM   532  C CA    . LEU   A 1 67  ? 20.893 10.623  18.057 1    43.45  ?  246 LEU   A CA    1 
ATOM   533  C C     . LEU   A 1 67  ? 19.671 11.506  18.27  1    45.42  ?  246 LEU   A C     1 
ATOM   534  O O     . LEU   A 1 67  ? 18.594 10.991  18.525 1    45.89  ?  246 LEU   A O     1 
ATOM   535  C CB    . LEU   A 1 67  ? 20.792 9.909   16.712 1    42.46  ?  246 LEU   A CB    1 
ATOM   536  C CG    . LEU   A 1 67  ? 21.996 9.072   16.33  1    42.65  ?  246 LEU   A CG    1 
ATOM   537  C CD1   . LEU   A 1 67  ? 21.734 8.319   15.073 1    42.58  ?  246 LEU   A CD1   1 
ATOM   538  C CD2   . LEU   A 1 67  ? 23.266 9.925   16.21  1    42.88  ?  246 LEU   A CD2   1 
ATOM   539  N N     . PRO   A 1 68  ? 19.821 12.837  18.218 1    46.62  ?  247 PRO   A N     1 
ATOM   540  C CA    . PRO   A 1 68  ? 18.674 13.72   18.495 1    47.32  ?  247 PRO   A CA    1 
ATOM   541  C C     . PRO   A 1 68  ? 17.42  13.479  17.65  1    47.48  ?  247 PRO   A C     1 
ATOM   542  O O     . PRO   A 1 68  ? 17.488 13.376  16.428 1    48.41  ?  247 PRO   A O     1 
ATOM   543  C CB    . PRO   A 1 68  ? 19.261 15.119  18.281 1    48.17  ?  247 PRO   A CB    1 
ATOM   544  C CG    . PRO   A 1 68  ? 20.717 14.947  18.611 1    48.47  ?  247 PRO   A CG    1 
ATOM   545  C CD    . PRO   A 1 68  ? 21.054 13.615  17.991 1    46.56  ?  247 PRO   A CD    1 
ATOM   546  N N     . GLY   A 1 69  ? 16.28  13.356  18.318 1    46.47  ?  248 GLY   A N     1 
ATOM   547  C CA    . GLY   A 1 69  ? 15.013 13.152  17.629 1    45.85  ?  248 GLY   A CA    1 
ATOM   548  C C     . GLY   A 1 69  ? 14.714 11.725  17.222 1    44.97  ?  248 GLY   A C     1 
ATOM   549  O O     . GLY   A 1 69  ? 13.56  11.419  16.906 1    45.09  ?  248 GLY   A O     1 
ATOM   550  N N     . PHE   A 1 70  ? 15.722 10.825  17.241 1    43.74  ?  249 PHE   A N     1 
ATOM   551  C CA    . PHE   A 1 70  ? 15.485 9.441   16.824 1    43.34  ?  249 PHE   A CA    1 
ATOM   552  C C     . PHE   A 1 70  ? 14.397 8.745   17.636 1    43.82  ?  249 PHE   A C     1 
ATOM   553  O O     . PHE   A 1 70  ? 13.539 8.074   17.052 1    43.64  ?  249 PHE   A O     1 
ATOM   554  C CB    . PHE   A 1 70  ? 16.776 8.609   16.829 1    42.43  ?  249 PHE   A CB    1 
ATOM   555  C CG    . PHE   A 1 70  ? 16.552 7.228   16.249 1    41.95  ?  249 PHE   A CG    1 
ATOM   556  C CD1   . PHE   A 1 70  ? 16.656 7.007   14.889 1    42.38  ?  249 PHE   A CD1   1 
ATOM   557  C CD2   . PHE   A 1 70  ? 16.239 6.155   17.067 1    41.86  ?  249 PHE   A CD2   1 
ATOM   558  C CE1   . PHE   A 1 70  ? 16.424 5.749   14.36  1    42.75  ?  249 PHE   A CE1   1 
ATOM   559  C CE2   . PHE   A 1 70  ? 16.023 4.897   16.534 1    42.18  ?  249 PHE   A CE2   1 
ATOM   560  C CZ    . PHE   A 1 70  ? 16.12  4.701   15.189 1    42.31  ?  249 PHE   A CZ    1 
ATOM   561  N N     . THR   A 1 71  ? 14.449 8.868   18.978 1    44.05  ?  250 THR   A N     1 
ATOM   562  C CA    . THR   A 1 71  ? 13.439 8.229   19.829 1    45.49  ?  250 THR   A CA    1 
ATOM   563  C C     . THR   A 1 71  ? 12.074 8.915   19.775 1    46.49  ?  250 THR   A C     1 
ATOM   564  O O     . THR   A 1 71  ? 11.116 8.338   20.283 1    46.78  ?  250 THR   A O     1 
ATOM   565  C CB    . THR   A 1 71  ? 13.915 8.05    21.275 1    47.03  ?  250 THR   A CB    1 
ATOM   566  O OG1   . THR   A 1 71  ? 14.165 9.33    21.863 1    48.34  ?  250 THR   A OG1   1 
ATOM   567  C CG2   . THR   A 1 71  ? 15.158 7.171   21.366 1    47.28  ?  250 THR   A CG2   1 
ATOM   568  N N     . THR   A 1 72  ? 11.968 10.106  19.13  1    47.04  ?  251 THR   A N     1 
ATOM   569  C CA    . THR   A 1 72  ? 10.694 10.805  18.946 1    48.16  ?  251 THR   A CA    1 
ATOM   570  C C     . THR   A 1 72  ? 9.931  10.295  17.715 1    48.34  ?  251 THR   A C     1 
ATOM   571  O O     . THR   A 1 72  ? 8.75   10.599  17.584 1    49.23  ?  251 THR   A O     1 
ATOM   572  C CB    . THR   A 1 72  ? 10.837 12.334  18.947 1    50.28  ?  251 THR   A CB    1 
ATOM   573  O OG1   . THR   A 1 72  ? 11.176 12.792  17.641 1    52.19  ?  251 THR   A OG1   1 
ATOM   574  C CG2   . THR   A 1 72  ? 11.842 12.84   19.975 1    51.02  ?  251 THR   A CG2   1 
ATOM   575  N N     . LEU   A 1 73  ? 10.586 9.551   16.804 1    47.25  ?  252 LEU   A N     1 
ATOM   576  C CA    . LEU   A 1 73  ? 9.891  8.959   15.659 1    46.73  ?  252 LEU   A CA    1 
ATOM   577  C C     . LEU   A 1 73  ? 9.005  7.817   16.185 1    46.47  ?  252 LEU   A C     1 
ATOM   578  O O     . LEU   A 1 73  ? 9.136  7.433   17.352 1    46.62  ?  252 LEU   A O     1 
ATOM   579  C CB    . LEU   A 1 73  ? 10.908 8.386   14.635 1    46.42  ?  252 LEU   A CB    1 
ATOM   580  C CG    . LEU   A 1 73  ? 11.958 9.355   14.104 1    47.37  ?  252 LEU   A CG    1 
ATOM   581  C CD1   . LEU   A 1 73  ? 13.008 8.622   13.291 1    47.58  ?  252 LEU   A CD1   1 
ATOM   582  C CD2   . LEU   A 1 73  ? 11.316 10.44   13.264 1    47.92  ?  252 LEU   A CD2   1 
ATOM   583  N N     . THR   A 1 74  ? 8.113  7.261   15.341 1    46.29  ?  253 THR   A N     1 
ATOM   584  C CA    . THR   A 1 74  ? 7.304  6.123   15.79  1    46.6   ?  253 THR   A CA    1 
ATOM   585  C C     . THR   A 1 74  ? 8.212  4.905   15.991 1    46.62  ?  253 THR   A C     1 
ATOM   586  O O     . THR   A 1 74  ? 9.268  4.821   15.361 1    46.6   ?  253 THR   A O     1 
ATOM   587  C CB    . THR   A 1 74  ? 6.138  5.839   14.844 1    47.67  ?  253 THR   A CB    1 
ATOM   588  O OG1   . THR   A 1 74  ? 6.626  5.289   13.625 1    48.24  ?  253 THR   A OG1   1 
ATOM   589  C CG2   . THR   A 1 74  ? 5.26   7.084   14.591 1    47.95  ?  253 THR   A CG2   1 
ATOM   590  N N     . ILE   A 1 75  ? 7.809  3.964   16.858 1    46.61  ?  254 ILE   A N     1 
ATOM   591  C CA    . ILE   A 1 75  ? 8.551  2.726   17.1   1    47.28  ?  254 ILE   A CA    1 
ATOM   592  C C     . ILE   A 1 75  ? 8.676  1.938   15.8   1    46.83  ?  254 ILE   A C     1 
ATOM   593  O O     . ILE   A 1 75  ? 9.753  1.414   15.508 1    46.75  ?  254 ILE   A O     1 
ATOM   594  C CB    . ILE   A 1 75  ? 7.91   1.887   18.234 1    48.69  ?  254 ILE   A CB    1 
ATOM   595  C CG1   . ILE   A 1 75  ? 8.168  2.544   19.599 1    49.77  ?  254 ILE   A CG1   1 
ATOM   596  C CG2   . ILE   A 1 75  ? 8.381  0.399   18.215 1    49.23  ?  254 ILE   A CG2   1 
ATOM   597  C CD1   . ILE   A 1 75  ? 9.586  2.526   20.028 1    51.23  ?  254 ILE   A CD1   1 
ATOM   598  N N     . ALA   A 1 76  ? 7.604  1.933   14.989 1    45.87  ?  255 ALA   A N     1 
ATOM   599  C CA    . ALA   A 1 76  ? 7.606  1.302   13.684 1    45.84  ?  255 ALA   A CA    1 
ATOM   600  C C     . ALA   A 1 76  ? 8.714  1.892   12.775 1    44.6   ?  255 ALA   A C     1 
ATOM   601  O O     . ALA   A 1 76  ? 9.453  1.135   12.146 1    44.51  ?  255 ALA   A O     1 
ATOM   602  C CB    . ALA   A 1 76  ? 6.239  1.467   13.03  1    46.51  ?  255 ALA   A CB    1 
ATOM   603  N N     . ASP   A 1 77  ? 8.855  3.23    12.737 1    43.27  ?  256 ASP   A N     1 
ATOM   604  C CA    . ASP   A 1 77  ? 9.877  3.86    11.908 1    42.58  ?  256 ASP   A CA    1 
ATOM   605  C C     . ASP   A 1 77  ? 11.288 3.687   12.471 1    41.14  ?  256 ASP   A C     1 
ATOM   606  O O     . ASP   A 1 77  ? 12.222 3.546   11.687 1    41.13  ?  256 ASP   A O     1 
ATOM   607  C CB    . ASP   A 1 77  ? 9.553  5.337   11.616 1    44.74  ?  256 ASP   A CB    1 
ATOM   608  C CG    . ASP   A 1 77  ? 8.467  5.539   10.559 1    49.79  ?  256 ASP   A CG    1 
ATOM   609  O OD1   . ASP   A 1 77  ? 7.997  4.529   9.983  1    50.5   ?  256 ASP   A OD1   1 
ATOM   610  O OD2   . ASP   A 1 77  ? 8.097  6.711   10.292 1    51.18  ?  256 ASP   A OD2   1 
ATOM   611  N N     . GLN   A 1 78  ? 11.451 3.612   13.807 1    39.5   ?  257 GLN   A N     1 
ATOM   612  C CA    . GLN   A 1 78  ? 12.775 3.359   14.395 1    38.38  ?  257 GLN   A CA    1 
ATOM   613  C C     . GLN   A 1 78  ? 13.256 1.967   13.967 1    37.96  ?  257 GLN   A C     1 
ATOM   614  O O     . GLN   A 1 78  ? 14.399 1.82    13.541 1    37.74  ?  257 GLN   A O     1 
ATOM   615  C CB    . GLN   A 1 78  ? 12.74  3.44    15.923 1    38.51  ?  257 GLN   A CB    1 
ATOM   616  C CG    . GLN   A 1 78  ? 12.46  4.826   16.456 1    41.62  ?  257 GLN   A CG    1 
ATOM   617  C CD    . GLN   A 1 78  ? 12.164 4.806   17.935 1    45.18  ?  257 GLN   A CD    1 
ATOM   618  O OE1   . GLN   A 1 78  ? 12.964 4.337   18.742 1    46.63  ?  257 GLN   A OE1   1 
ATOM   619  N NE2   . GLN   A 1 78  ? 11.013 5.321   18.326 1    44.42  ?  257 GLN   A NE2   1 
ATOM   620  N N     . ILE   A 1 79  ? 12.345 0.975   14.019 1    37.26  ?  258 ILE   A N     1 
ATOM   621  C CA    . ILE   A 1 79  ? 12.59  -0.407  13.642 1    37.82  ?  258 ILE   A CA    1 
ATOM   622  C C     . ILE   A 1 79  ? 12.916 -0.512  12.157 1    38.23  ?  258 ILE   A C     1 
ATOM   623  O O     . ILE   A 1 79  ? 13.858 -1.224  11.785 1    38.87  ?  258 ILE   A O     1 
ATOM   624  C CB    . ILE   A 1 79  ? 11.39  -1.32   14.047 1    38.04  ?  258 ILE   A CB    1 
ATOM   625  C CG1   . ILE   A 1 79  ? 11.288 -1.447  15.568 1    38.33  ?  258 ILE   A CG1   1 
ATOM   626  C CG2   . ILE   A 1 79  ? 11.494 -2.717  13.388 1    38.78  ?  258 ILE   A CG2   1 
ATOM   627  C CD1   . ILE   A 1 79  ? 10.075 -2.245  16.075 1    39.61  ?  258 ILE   A CD1   1 
ATOM   628  N N     . THR   A 1 80  ? 12.166 0.222   11.312 1    37.18  ?  259 THR   A N     1 
ATOM   629  C CA    . THR   A 1 80  ? 12.391 0.211   9.872  1    36.85  ?  259 THR   A CA    1 
ATOM   630  C C     . THR   A 1 80  ? 13.74  0.803   9.53   1    36.07  ?  259 THR   A C     1 
ATOM   631  O O     . THR   A 1 80  ? 14.438 0.246   8.678  1    36.23  ?  259 THR   A O     1 
ATOM   632  C CB    . THR   A 1 80  ? 11.218 0.859   9.107  1    39.1   ?  259 THR   A CB    1 
ATOM   633  O OG1   . THR   A 1 80  ? 10.138 -0.081  9.094  1    41.09  ?  259 THR   A OG1   1 
ATOM   634  C CG2   . THR   A 1 80  ? 11.568 1.203   7.661  1    39.5   ?  259 THR   A CG2   1 
ATOM   635  N N     . LEU   A 1 81  ? 14.131 1.898   10.206 1    34.86  ?  260 LEU   A N     1 
ATOM   636  C CA    . LEU   A 1 81  ? 15.413 2.534   9.965  1    34.76  ?  260 LEU   A CA    1 
ATOM   637  C C     . LEU   A 1 81  ? 16.602 1.65    10.425 1    35.49  ?  260 LEU   A C     1 
ATOM   638  O O     . LEU   A 1 81  ? 17.616 1.562   9.721  1    35.11  ?  260 LEU   A O     1 
ATOM   639  C CB    . LEU   A 1 81  ? 15.491 3.914   10.65  1    34.69  ?  260 LEU   A CB    1 
ATOM   640  C CG    . LEU   A 1 81  ? 14.538 5.017   10.113 1    36.52  ?  260 LEU   A CG    1 
ATOM   641  C CD1   . LEU   A 1 81  ? 14.815 6.36    10.814 1    37.37  ?  260 LEU   A CD1   1 
ATOM   642  C CD2   . LEU   A 1 81  ? 14.66  5.182   8.602  1    36.42  ?  260 LEU   A CD2   1 
ATOM   643  N N     . LEU   A 1 82  ? 16.473 1.032   11.618 1    35.17  ?  261 LEU   A N     1 
ATOM   644  C CA    . LEU   A 1 82  ? 17.535 0.228   12.178 1    35.62  ?  261 LEU   A CA    1 
ATOM   645  C C     . LEU   A 1 82  ? 17.787 -1      11.337 1    36.21  ?  261 LEU   A C     1 
ATOM   646  O O     . LEU   A 1 82  ? 18.94  -1.282  11.031 1    35.54  ?  261 LEU   A O     1 
ATOM   647  C CB    . LEU   A 1 82  ? 17.295 -0.077  13.66  1    35.09  ?  261 LEU   A CB    1 
ATOM   648  C CG    . LEU   A 1 82  ? 17.732 1.083   14.538 1    36     ?  261 LEU   A CG    1 
ATOM   649  C CD1   . LEU   A 1 82  ? 16.957 1.152   15.788 1    36.44  ?  261 LEU   A CD1   1 
ATOM   650  C CD2   . LEU   A 1 82  ? 19.239 1.058   14.783 1    36.84  ?  261 LEU   A CD2   1 
ATOM   651  N N     . LYS   A 1 83  ? 16.723 -1.638  10.846 1    36.76  ?  262 LYS   A N     1 
ATOM   652  C CA    . LYS   A 1 83  ? 16.849 -2.809  9.968  1    37.56  ?  262 LYS   A CA    1 
ATOM   653  C C     . LYS   A 1 83  ? 17.438 -2.453  8.586  1    38.23  ?  262 LYS   A C     1 
ATOM   654  O O     . LYS   A 1 83  ? 18.282 -3.191  8.066  1    38.69  ?  262 LYS   A O     1 
ATOM   655  C CB    . LYS   A 1 83  ? 15.504 -3.521  9.836  1    38.7   ?  262 LYS   A CB    1 
ATOM   656  C CG    . LYS   A 1 83  ? 15.177 -4.342  11.08  1    43.76  ?  262 LYS   A CG    1 
ATOM   657  C CD    . LYS   A 1 83  ? 13.694 -4.68   11.223 1    50.44  ?  262 LYS   A CD    1 
ATOM   658  C CE    . LYS   A 1 83  ? 13.033 -5.152  9.948  1    56.49  ?  262 LYS   A CE    1 
ATOM   659  N NZ    . LYS   A 1 83  ? 12.75  -6.619  9.967  1    60.85  ?  262 LYS   A NZ    1 
ATOM   660  N N     . ALA   A 1 84  ? 17.035 -1.31   8.025  1    37.58  ?  263 ALA   A N     1 
ATOM   661  C CA    . ALA   A 1 84  ? 17.574 -0.886  6.741  1    37.96  ?  263 ALA   A CA    1 
ATOM   662  C C     . ALA   A 1 84  ? 19.06  -0.482  6.812  1    37.45  ?  263 ALA   A C     1 
ATOM   663  O O     . ALA   A 1 84  ? 19.782 -0.688  5.851  1    38.02  ?  263 ALA   A O     1 
ATOM   664  C CB    . ALA   A 1 84  ? 16.74  0.247   6.163  1    37.96  ?  263 ALA   A CB    1 
ATOM   665  N N     . ALA   A 1 85  ? 19.501 0.102   7.914  1    36.92  ?  264 ALA   A N     1 
ATOM   666  C CA    . ALA   A 1 85  ? 20.883 0.562   8.068  1    37.06  ?  264 ALA   A CA    1 
ATOM   667  C C     . ALA   A 1 85  ? 21.804 -0.404  8.809  1    37.4   ?  264 ALA   A C     1 
ATOM   668  O O     . ALA   A 1 85  ? 22.996 -0.126  8.921  1    36.86  ?  264 ALA   A O     1 
ATOM   669  C CB    . ALA   A 1 85  ? 20.906 1.898   8.79   1    36.91  ?  264 ALA   A CB    1 
ATOM   670  N N     . CYS   A 1 86  ? 21.264 -1.501  9.337  1    37.99  ?  265 CYS   A N     1 
ATOM   671  C CA    . CYS   A 1 86  ? 22.011 -2.476  10.123 1    39.37  ?  265 CYS   A CA    1 
ATOM   672  C C     . CYS   A 1 86  ? 23.38  -2.881  9.513  1    39.49  ?  265 CYS   A C     1 
ATOM   673  O O     . CYS   A 1 86  ? 24.413 -2.636  10.133 1    39.73  ?  265 CYS   A O     1 
ATOM   674  C CB    . CYS   A 1 86  ? 21.142 -3.698  10.401 1    40.9   ?  265 CYS   A CB    1 
ATOM   675  S SG    . CYS   A 1 86  ? 21.94  -4.922  11.456 1    46.3   ?  265 CYS   A SG    1 
ATOM   676  N N     . LEU   A 1 87  ? 23.382 -3.481  8.307  1    39.33  ?  266 LEU   A N     1 
ATOM   677  C CA    . LEU   A 1 87  ? 24.617 -3.915  7.667  1    39.94  ?  266 LEU   A CA    1 
ATOM   678  C C     . LEU   A 1 87  ? 25.514 -2.759  7.312  1    39.53  ?  266 LEU   A C     1 
ATOM   679  O O     . LEU   A 1 87  ? 26.722 -2.882  7.46   1    40.11  ?  266 LEU   A O     1 
ATOM   680  C CB    . LEU   A 1 87  ? 24.361 -4.787  6.429  1    40.57  ?  266 LEU   A CB    1 
ATOM   681  C CG    . LEU   A 1 87  ? 24.082 -6.273  6.684  1    42.94  ?  266 LEU   A CG    1 
ATOM   682  C CD1   . LEU   A 1 87  ? 24.054 -7.043  5.37   1    43.53  ?  266 LEU   A CD1   1 
ATOM   683  C CD2   . LEU   A 1 87  ? 25.119 -6.908  7.639  1    43.79  ?  266 LEU   A CD2   1 
ATOM   684  N N     . ASP   A 1 88  ? 24.944 -1.615  6.907  1    38.3   ?  267 ASP   A N     1 
ATOM   685  C CA    . ASP   A 1 88  ? 25.747 -0.44   6.571  1    37.73  ?  267 ASP   A CA    1 
ATOM   686  C C     . ASP   A 1 88  ? 26.59  0.012   7.747  1    35.9   ?  267 ASP   A C     1 
ATOM   687  O O     . ASP   A 1 88  ? 27.765 0.325   7.571  1    36.82  ?  267 ASP   A O     1 
ATOM   688  C CB    . ASP   A 1 88  ? 24.859 0.739   6.164  1    41.02  ?  267 ASP   A CB    1 
ATOM   689  C CG    . ASP   A 1 88  ? 23.836 0.457   5.085  1    50.88  ?  267 ASP   A CG    1 
ATOM   690  O OD1   . ASP   A 1 88  ? 23.906 1.107   4.015  1    52.95  ?  267 ASP   A OD1   1 
ATOM   691  O OD2   . ASP   A 1 88  ? 22.941 -0.398  5.316  1    53.98  ?  267 ASP   A OD2   1 
ATOM   692  N N     . ILE   A 1 89  ? 25.988 0.062   8.939  1    33.19  ?  268 ILE   A N     1 
ATOM   693  C CA    . ILE   A 1 89  ? 26.687 0.516   10.133 1    32.06  ?  268 ILE   A CA    1 
ATOM   694  C C     . ILE   A 1 89  ? 27.688 -0.527  10.642 1    30.54  ?  268 ILE   A C     1 
ATOM   695  O O     . ILE   A 1 89  ? 28.793 -0.152  11.002 1    30.07  ?  268 ILE   A O     1 
ATOM   696  C CB    . ILE   A 1 89  ? 25.69  0.974   11.217 1    31.75  ?  268 ILE   A CB    1 
ATOM   697  C CG1   . ILE   A 1 89  ? 24.843 2.116   10.655 1    33.04  ?  268 ILE   A CG1   1 
ATOM   698  C CG2   . ILE   A 1 89  ? 26.441 1.414   12.477 1    31.4   ?  268 ILE   A CG2   1 
ATOM   699  C CD1   . ILE   A 1 89  ? 23.782 2.649   11.629 1    34.74  ?  268 ILE   A CD1   1 
ATOM   700  N N     . LEU   A 1 90  ? 27.34  -1.834  10.601 1    30.2   ?  269 LEU   A N     1 
ATOM   701  C CA    . LEU   A 1 90  ? 28.299 -2.857  11.039 1    30.99  ?  269 LEU   A CA    1 
ATOM   702  C C     . LEU   A 1 90  ? 29.505 -2.855  10.104 1    30.48  ?  269 LEU   A C     1 
ATOM   703  O O     . LEU   A 1 90  ? 30.621 -2.95   10.571 1    30.07  ?  269 LEU   A O     1 
ATOM   704  C CB    . LEU   A 1 90  ? 27.697 -4.277  11.063 1    31.73  ?  269 LEU   A CB    1 
ATOM   705  C CG    . LEU   A 1 90  ? 26.448 -4.605  11.885 1    34.48  ?  269 LEU   A CG    1 
ATOM   706  C CD1   . LEU   A 1 90  ? 26.36  -6.109  12.14  1    34.97  ?  269 LEU   A CD1   1 
ATOM   707  C CD2   . LEU   A 1 90  ? 26.387 -3.845  13.192 1    34.26  ?  269 LEU   A CD2   1 
ATOM   708  N N     . ILE   A 1 91  ? 29.277 -2.695  8.782  1    31.02  ?  270 ILE   A N     1 
ATOM   709  C CA    . ILE   A 1 91  ? 30.368 -2.707  7.803  1    31.67  ?  270 ILE   A CA    1 
ATOM   710  C C     . ILE   A 1 91  ? 31.254 -1.485  7.961  1    32.08  ?  270 ILE   A C     1 
ATOM   711  O O     . ILE   A 1 91  ? 32.467 -1.642  7.995  1    33.16  ?  270 ILE   A O     1 
ATOM   712  C CB    . ILE   A 1 91  ? 29.851 -2.932  6.354  1    31.75  ?  270 ILE   A CB    1 
ATOM   713  C CG1   . ILE   A 1 91  ? 29.394 -4.398  6.211  1    32.43  ?  270 ILE   A CG1   1 
ATOM   714  C CG2   . ILE   A 1 91  ? 30.923 -2.588  5.325  1    31.93  ?  270 ILE   A CG2   1 
ATOM   715  C CD1   . ILE   A 1 91  ? 28.343 -4.674  5.165  1    33.69  ?  270 ILE   A CD1   1 
ATOM   716  N N     . LEU   A 1 92  ? 30.676 -0.299  8.155  1    31.49  ?  271 LEU   A N     1 
ATOM   717  C CA    . LEU   A 1 92  ? 31.462 0.913   8.379  1    32.13  ?  271 LEU   A CA    1 
ATOM   718  C C     . LEU   A 1 92  ? 32.308 0.779   9.654  1    32.84  ?  271 LEU   A C     1 
ATOM   719  O O     . LEU   A 1 92  ? 33.485 1.165   9.659  1    33.65  ?  271 LEU   A O     1 
ATOM   720  C CB    . LEU   A 1 92  ? 30.517 2.119   8.487  1    32.33  ?  271 LEU   A CB    1 
ATOM   721  C CG    . LEU   A 1 92  ? 31.123 3.496   8.817  1    33.54  ?  271 LEU   A CG    1 
ATOM   722  C CD1   . LEU   A 1 92  ? 32.275 3.856   7.834  1    34.41  ?  271 LEU   A CD1   1 
ATOM   723  C CD2   . LEU   A 1 92  ? 30.025 4.576   8.777  1    32.89  ?  271 LEU   A CD2   1 
ATOM   724  N N     . ARG   A 1 93  ? 31.737 0.164   10.705 1    32.25  ?  272 ARG   A N     1 
ATOM   725  C CA    . ARG   A 1 93  ? 32.464 -0.051  11.96  1    31.69  ?  272 ARG   A CA    1 
ATOM   726  C C     . ARG   A 1 93  ? 33.615 -1.039  11.802 1    30.42  ?  272 ARG   A C     1 
ATOM   727  O O     . ARG   A 1 93  ? 34.727 -0.728  12.241 1    29.62  ?  272 ARG   A O     1 
ATOM   728  C CB    . ARG   A 1 93  ? 31.51  -0.466  13.104 1    32.85  ?  272 ARG   A CB    1 
ATOM   729  C CG    . ARG   A 1 93  ? 30.65  0.693   13.593 1    35.23  ?  272 ARG   A CG    1 
ATOM   730  C CD    . ARG   A 1 93  ? 29.638 0.298   14.649 1    36.8   ?  272 ARG   A CD    1 
ATOM   731  N NE    . ARG   A 1 93  ? 29.001 1.467   15.264 1    38.86  ?  272 ARG   A NE    1 
ATOM   732  C CZ    . ARG   A 1 93  ? 28.829 1.622   16.577 1    41.08  ?  272 ARG   A CZ    1 
ATOM   733  N NH1   . ARG   A 1 93  ? 29.266 0.696   17.428 1    39.38  ?  272 ARG   A NH1   1 
ATOM   734  N NH2   . ARG   A 1 93  ? 28.247 2.718   17.052 1    41.02  ?  272 ARG   A NH2   1 
ATOM   735  N N     . ILE   A 1 94  ? 33.385 -2.199  11.141 1    29.94  ?  273 ILE   A N     1 
ATOM   736  C CA    . ILE   A 1 94  ? 34.48  -3.159  10.982 1    30.24  ?  273 ILE   A CA    1 
ATOM   737  C C     . ILE   A 1 94  ? 35.602 -2.573  10.078 1    31.03  ?  273 ILE   A C     1 
ATOM   738  O O     . ILE   A 1 94  ? 36.794 -2.734  10.388 1    31.86  ?  273 ILE   A O     1 
ATOM   739  C CB    . ILE   A 1 94  ? 34.027 -4.584  10.566 1    30.16  ?  273 ILE   A CB    1 
ATOM   740  C CG1   . ILE   A 1 94  ? 35.173 -5.62   10.796 1    30.9   ?  273 ILE   A CG1   1 
ATOM   741  C CG2   . ILE   A 1 94  ? 33.544 -4.635  9.114  1    30.55  ?  273 ILE   A CG2   1 
ATOM   742  C CD1   . ILE   A 1 94  ? 35.732 -5.634  12.211 1    31.55  ?  273 ILE   A CD1   1 
ATOM   743  N N     . CYS   A 1 95  ? 35.218 -1.784  9.061  1    30.9   ?  274 CYS   A N     1 
ATOM   744  C CA    . CYS   A 1 95  ? 36.175 -1.166  8.16   1    32.41  ?  274 CYS   A CA    1 
ATOM   745  C C     . CYS   A 1 95  ? 36.931 -0.01   8.783  1    33.4   ?  274 CYS   A C     1 
ATOM   746  O O     . CYS   A 1 95  ? 38.054 0.251   8.368  1    34.37  ?  274 CYS   A O     1 
ATOM   747  C CB    . CYS   A 1 95  ? 35.522 -0.774  6.845  1    32.97  ?  274 CYS   A CB    1 
ATOM   748  S SG    . CYS   A 1 95  ? 34.974 -2.195  5.881  1    36.83  ?  274 CYS   A SG    1 
ATOM   749  N N     . THR   A 1 96  ? 36.376 0.623   9.821  1    33.37  ?  275 THR   A N     1 
ATOM   750  C CA    . THR   A 1 96  ? 37.092 1.653   10.554 1    33.93  ?  275 THR   A CA    1 
ATOM   751  C C     . THR   A 1 96  ? 38.297 1.04    11.324 1    34.58  ?  275 THR   A C     1 
ATOM   752  O O     . THR   A 1 96  ? 39.243 1.764   11.629 1    35.82  ?  275 THR   A O     1 
ATOM   753  C CB    . THR   A 1 96  ? 36.108 2.414   11.436 1    34.77  ?  275 THR   A CB    1 
ATOM   754  O OG1   . THR   A 1 96  ? 35.138 3.029   10.581 1    36.32  ?  275 THR   A OG1   1 
ATOM   755  C CG2   . THR   A 1 96  ? 36.771 3.478   12.282 1    34.86  ?  275 THR   A CG2   1 
ATOM   756  N N     . ARG   A 1 97  ? 38.291 -0.291  11.605 1    33.33  ?  276 ARG   A N     1 
ATOM   757  C CA    . ARG   A 1 97  ? 39.411 -0.924  12.309 1    33.26  ?  276 ARG   A CA    1 
ATOM   758  C C     . ARG   A 1 97  ? 40.289 -1.752  11.364 1    34.71  ?  276 ARG   A C     1 
ATOM   759  O O     . ARG   A 1 97  ? 40.687 -2.88   11.692 1    34.48  ?  276 ARG   A O     1 
ATOM   760  C CB    . ARG   A 1 97  ? 38.9   -1.79   13.471 1    32.87  ?  276 ARG   A CB    1 
ATOM   761  C CG    . ARG   A 1 97  ? 38.057 -1.02   14.469 1    32.17  ?  276 ARG   A CG    1 
ATOM   762  C CD    . ARG   A 1 97  ? 38.203 -1.599  15.868 1    30.43  ?  276 ARG   A CD    1 
ATOM   763  N NE    . ARG   A 1 97  ? 37.097 -1.163  16.72  1    29.59  ?  276 ARG   A NE    1 
ATOM   764  C CZ    . ARG   A 1 97  ? 35.93  -1.785  16.812 1    29.66  ?  276 ARG   A CZ    1 
ATOM   765  N NH1   . ARG   A 1 97  ? 35.696 -2.882  16.102 1    26.27  ?  276 ARG   A NH1   1 
ATOM   766  N NH2   . ARG   A 1 97  ? 34.967 -1.289  17.58  1    31.26  ?  276 ARG   A NH2   1 
ATOM   767  N N     . TYR   A 1 98  ? 40.571 -1.192  10.178 1    35.79  ?  277 TYR   A N     1 
ATOM   768  C CA    . TYR   A 1 98  ? 41.388 -1.848  9.171  1    37.39  ?  277 TYR   A CA    1 
ATOM   769  C C     . TYR   A 1 98  ? 42.875 -1.568  9.387  1    37.92  ?  277 TYR   A C     1 
ATOM   770  O O     . TYR   A 1 98  ? 43.252 -0.448  9.734  1    37.54  ?  277 TYR   A O     1 
ATOM   771  C CB    . TYR   A 1 98  ? 40.951 -1.392  7.766  1    38.11  ?  277 TYR   A CB    1 
ATOM   772  C CG    . TYR   A 1 98  ? 41.738 -2.048  6.655  1    39.22  ?  277 TYR   A CG    1 
ATOM   773  C CD1   . TYR   A 1 98  ? 41.689 -3.42   6.461  1    40.24  ?  277 TYR   A CD1   1 
ATOM   774  C CD2   . TYR   A 1 98  ? 42.5   -1.292  5.776  1    40.56  ?  277 TYR   A CD2   1 
ATOM   775  C CE1   . TYR   A 1 98  ? 42.418 -4.032  5.451  1    41.73  ?  277 TYR   A CE1   1 
ATOM   776  C CE2   . TYR   A 1 98  ? 43.221 -1.889  4.747  1    41.69  ?  277 TYR   A CE2   1 
ATOM   777  C CZ    . TYR   A 1 98  ? 43.181 -3.262  4.589  1    42.97  ?  277 TYR   A CZ    1 
ATOM   778  O OH    . TYR   A 1 98  ? 43.892 -3.868  3.581  1    44.42  ?  277 TYR   A OH    1 
ATOM   779  N N     . THR   A 1 99  ? 43.72  -2.593  9.232  1    38.99  ?  278 THR   A N     1 
ATOM   780  C CA    . THR   A 1 99  ? 45.175 -2.429  9.362  1    40.42  ?  278 THR   A CA    1 
ATOM   781  C C     . THR   A 1 99  ? 45.768 -2.816  8.013  1    41.47  ?  278 THR   A C     1 
ATOM   782  O O     . THR   A 1 99  ? 45.788 -4      7.673  1    42.17  ?  278 THR   A O     1 
ATOM   783  C CB    . THR   A 1 99  ? 45.724 -3.304  10.497 1    42.02  ?  278 THR   A CB    1 
ATOM   784  O OG1   . THR   A 1 99  ? 45.034 -2.983  11.712 1    42.91  ?  278 THR   A OG1   1 
ATOM   785  C CG2   . THR   A 1 99  ? 47.235 -3.141  10.678 1    42.01  ?  278 THR   A CG2   1 
ATOM   786  N N     . PRO   A 1 100 ? 46.153 -1.836  7.191  1    42.17  ?  279 PRO   A N     1 
ATOM   787  C CA    . PRO   A 1 100 ? 46.612 -2.158  5.824  1    43.5   ?  279 PRO   A CA    1 
ATOM   788  C C     . PRO   A 1 100 ? 47.818 -3.074  5.725  1    45.16  ?  279 PRO   A C     1 
ATOM   789  O O     . PRO   A 1 100 ? 47.792 -4.02   4.934  1    45.39  ?  279 PRO   A O     1 
ATOM   790  C CB    . PRO   A 1 100 ? 46.89  -0.793  5.19   1    43.94  ?  279 PRO   A CB    1 
ATOM   791  C CG    . PRO   A 1 100 ? 46.184 0.176   6.014  1    44.39  ?  279 PRO   A CG    1 
ATOM   792  C CD    . PRO   A 1 100 ? 46.114 -0.384  7.422  1    42.33  ?  279 PRO   A CD    1 
ATOM   793  N N     . GLU   A 1 101 ? 48.822 -2.86   6.573  1    46.46  ?  280 GLU   A N     1 
ATOM   794  C CA    . GLU   A 1 101 ? 50.051 -3.654  6.549  1    48.24  ?  280 GLU   A CA    1 
ATOM   795  C C     . GLU   A 1 101 ? 49.802 -5.155  6.646  1    48.07  ?  280 GLU   A C     1 
ATOM   796  O O     . GLU   A 1 101 ? 50.272 -5.896  5.78   1    48.19  ?  280 GLU   A O     1 
ATOM   797  C CB    . GLU   A 1 101 ? 51.035 -3.173  7.623  1    52.9   ?  280 GLU   A CB    1 
ATOM   798  C CG    . GLU   A 1 101 ? 51.485 -1.731  7.421  1    60.89  ?  280 GLU   A CG    1 
ATOM   799  C CD    . GLU   A 1 101 ? 50.558 -0.672  7.993  1    70.6   ?  280 GLU   A CD    1 
ATOM   800  O OE1   . GLU   A 1 101 ? 49.539 -1.043  8.623  1    72.03  ?  280 GLU   A OE1   1 
ATOM   801  O OE2   . GLU   A 1 101 ? 50.848 0.532   7.8    1    73.56  ?  280 GLU   A OE2   1 
ATOM   802  N N     . GLN   A 1 102 ? 48.981 -5.597  7.627  1    46.99  ?  281 GLN   A N     1 
ATOM   803  C CA    . GLN   A 1 102 ? 48.669 -7.023  7.741  1    46.06  ?  281 GLN   A CA    1 
ATOM   804  C C     . GLN   A 1 102 ? 47.386 -7.449  7.024  1    43.64  ?  281 GLN   A C     1 
ATOM   805  O O     . GLN   A 1 102 ? 47.097 -8.653  6.977  1    43.7   ?  281 GLN   A O     1 
ATOM   806  C CB    . GLN   A 1 102 ? 48.644 -7.476  9.204  1    49.15  ?  281 GLN   A CB    1 
ATOM   807  C CG    . GLN   A 1 102 ? 50.036 -7.609  9.833  1    54.83  ?  281 GLN   A CG    1 
ATOM   808  C CD    . GLN   A 1 102 ? 50.587 -6.296  10.34  1    61.36  ?  281 GLN   A CD    1 
ATOM   809  O OE1   . GLN   A 1 102 ? 49.908 -5.263  10.363 1    63.4   ?  281 GLN   A OE1   1 
ATOM   810  N NE2   . GLN   A 1 102 ? 51.835 -6.31   10.769 1    62.93  ?  281 GLN   A NE2   1 
ATOM   811  N N     . ASP   A 1 103 ? 46.637 -6.479  6.445  1    41.22  ?  282 ASP   A N     1 
ATOM   812  C CA    . ASP   A 1 103 ? 45.395 -6.712  5.707  1    39.09  ?  282 ASP   A CA    1 
ATOM   813  C C     . ASP   A 1 103 ? 44.365 -7.374  6.633  1    36.19  ?  282 ASP   A C     1 
ATOM   814  O O     . ASP   A 1 103 ? 43.795 -8.421  6.326  1    34.9   ?  282 ASP   A O     1 
ATOM   815  C CB    . ASP   A 1 103 ? 45.676 -7.569  4.465  1    40.68  ?  282 ASP   A CB    1 
ATOM   816  C CG    . ASP   A 1 103 ? 44.568 -7.536  3.442  1    45.84  ?  282 ASP   A CG    1 
ATOM   817  O OD1   . ASP   A 1 103 ? 43.993 -6.438  3.222  1    46.67  ?  282 ASP   A OD1   1 
ATOM   818  O OD2   . ASP   A 1 103 ? 44.265 -8.601  2.869  1    47.6   ?  282 ASP   A OD2   1 
ATOM   819  N N     . THR   A 1 104 ? 44.202 -6.794  7.811  1    35.27  ?  283 THR   A N     1 
ATOM   820  C CA    . THR   A 1 104 ? 43.311 -7.36   8.831  1    34.17  ?  283 THR   A CA    1 
ATOM   821  C C     . THR   A 1 104 ? 42.239 -6.4    9.27   1    33.12  ?  283 THR   A C     1 
ATOM   822  O O     . THR   A 1 104 ? 42.439 -5.199  9.203  1    33.84  ?  283 THR   A O     1 
ATOM   823  C CB    . THR   A 1 104 ? 44.137 -7.7    10.097 1    34.56  ?  283 THR   A CB    1 
ATOM   824  O OG1   . THR   A 1 104 ? 44.596 -6.49   10.699 1    35.31  ?  283 THR   A OG1   1 
ATOM   825  C CG2   . THR   A 1 104 ? 45.271 -8.675  9.847  1    34.45  ?  283 THR   A CG2   1 
ATOM   826  N N     . MET   A 1 105 ? 41.163 -6.914  9.87   1    32.5   ?  284 MET   A N     1 
ATOM   827  C CA    . MET   A 1 105 ? 40.16  -6.076  10.5   1    31.46  ?  284 MET   A CA    1 
ATOM   828  C C     . MET   A 1 105 ? 40.032 -6.491  11.968 1    30.12  ?  284 MET   A C     1 
ATOM   829  O O     . MET   A 1 105 ? 40.141 -7.681  12.289 1    29.57  ?  284 MET   A O     1 
ATOM   830  C CB    . MET   A 1 105 ? 38.842 -6.13   9.743  1    32.93  ?  284 MET   A CB    1 
ATOM   831  C CG    . MET   A 1 105 ? 39.013 -5.758  8.275  1    38.15  ?  284 MET   A CG    1 
ATOM   832  S SD    . MET   A 1 105 ? 37.597 -4.904  7.587  1    52.99  ?  284 MET   A SD    1 
ATOM   833  C CE    . MET   A 1 105 ? 38.151 -4.682  5.907  1    49.42  ?  284 MET   A CE    1 
ATOM   834  N N     . THR   A 1 106 ? 39.853 -5.516  12.869 1    29.18  ?  285 THR   A N     1 
ATOM   835  C CA    . THR   A 1 106 ? 39.755 -5.844  14.29  1    28.94  ?  285 THR   A CA    1 
ATOM   836  C C     . THR   A 1 106 ? 38.333 -5.621  14.813 1    28.87  ?  285 THR   A C     1 
ATOM   837  O O     . THR   A 1 106 ? 37.808 -4.529  14.669 1    29.11  ?  285 THR   A O     1 
ATOM   838  C CB    . THR   A 1 106 ? 40.808 -5.086  15.101 1    30.19  ?  285 THR   A CB    1 
ATOM   839  O OG1   . THR   A 1 106 ? 42.124 -5.563  14.766 1    32.53  ?  285 THR   A OG1   1 
ATOM   840  C CG2   . THR   A 1 106 ? 40.613 -5.223  16.592 1    29.57  ?  285 THR   A CG2   1 
ATOM   841  N N     . PHE   A 1 107 ? 37.734 -6.648  15.435 1    28.21  ?  286 PHE   A N     1 
ATOM   842  C CA    . PHE   A 1 107 ? 36.426 -6.582  16.058 1    28.85  ?  286 PHE   A CA    1 
ATOM   843  C C     . PHE   A 1 107 ? 36.499 -5.891  17.43  1    29.12  ?  286 PHE   A C     1 
ATOM   844  O O     . PHE   A 1 107 ? 37.598 -5.607  17.931 1    28.4   ?  286 PHE   A O     1 
ATOM   845  C CB    . PHE   A 1 107 ? 35.799 -7.982  16.137 1    29.3   ?  286 PHE   A CB    1 
ATOM   846  C CG    . PHE   A 1 107 ? 35.473 -8.514  14.755 1    30.19  ?  286 PHE   A CG    1 
ATOM   847  C CD1   . PHE   A 1 107 ? 36.441 -9.147  13.988 1    30.77  ?  286 PHE   A CD1   1 
ATOM   848  C CD2   . PHE   A 1 107 ? 34.218 -8.335  14.206 1    30.63  ?  286 PHE   A CD2   1 
ATOM   849  C CE1   . PHE   A 1 107 ? 36.146 -9.602  12.697 1    31.15  ?  286 PHE   A CE1   1 
ATOM   850  C CE2   . PHE   A 1 107 ? 33.922 -8.79   12.922 1    31.39  ?  286 PHE   A CE2   1 
ATOM   851  C CZ    . PHE   A 1 107 ? 34.888 -9.419  12.174 1    31.27  ?  286 PHE   A CZ    1 
ATOM   852  N N     . SER   A 1 108 ? 35.325 -5.564  18.011 1    29.2   ?  287 SER   A N     1 
ATOM   853  C CA    . SER   A 1 108 ? 35.195 -4.837  19.266 1    30.61  ?  287 SER   A CA    1 
ATOM   854  C C     . SER   A 1 108 ? 35.835 -5.516  20.489 1    30.62  ?  287 SER   A C     1 
ATOM   855  O O     . SER   A 1 108 ? 36.079 -4.816  21.462 1    31.21  ?  287 SER   A O     1 
ATOM   856  C CB    . SER   A 1 108 ? 33.735 -4.498  19.557 1    33.09  ?  287 SER   A CB    1 
ATOM   857  O OG    . SER   A 1 108 ? 33.323 -3.476  18.662 1    37.62  ?  287 SER   A OG    1 
ATOM   858  N N     . ASP   A 1 109 ? 36.038 -6.843  20.485 1    29.92  ?  288 ASP   A N     1 
ATOM   859  C CA    . ASP   A 1 109 ? 36.749 -7.474  21.622 1    30.41  ?  288 ASP   A CA    1 
ATOM   860  C C     . ASP   A 1 109 ? 38.263 -7.55   21.409 1    30.12  ?  288 ASP   A C     1 
ATOM   861  O O     . ASP   A 1 109 ? 38.968 -8.015  22.29  1    31.2   ?  288 ASP   A O     1 
ATOM   862  C CB    . ASP   A 1 109 ? 36.201 -8.871  21.955 1    33.16  ?  288 ASP   A CB    1 
ATOM   863  C CG    . ASP   A 1 109 ? 36.391 -9.905  20.845 1    37.87  ?  288 ASP   A CG    1 
ATOM   864  O OD1   . ASP   A 1 109 ? 36.745 -9.509  19.71  1    37.07  ?  288 ASP   A OD1   1 
ATOM   865  O OD2   . ASP   A 1 109 ? 36.163 -11.102 21.107 1    41.92  ?  288 ASP   A OD2   1 
ATOM   866  N N     . GLY   A 1 110 ? 38.755 -7.129  20.245 1    29.15  ?  289 GLY   A N     1 
ATOM   867  C CA    . GLY   A 1 110 ? 40.166 -7.21   19.912 1    28.43  ?  289 GLY   A CA    1 
ATOM   868  C C     . GLY   A 1 110 ? 40.498 -8.286  18.896 1    28.06  ?  289 GLY   A C     1 
ATOM   869  O O     . GLY   A 1 110 ? 41.637 -8.35   18.452 1    28.87  ?  289 GLY   A O     1 
ATOM   870  N N     . LEU   A 1 111 ? 39.553 -9.173  18.552 1    27.54  ?  290 LEU   A N     1 
ATOM   871  C CA    . LEU   A 1 111 ? 39.761 -10.259 17.587 1    28.33  ?  290 LEU   A CA    1 
ATOM   872  C C     . LEU   A 1 111 ? 40.138 -9.665  16.238 1    29.95  ?  290 LEU   A C     1 
ATOM   873  O O     . LEU   A 1 111 ? 39.408 -8.846  15.708 1    30.39  ?  290 LEU   A O     1 
ATOM   874  C CB    . LEU   A 1 111 ? 38.483 -11.092 17.427 1    28.68  ?  290 LEU   A CB    1 
ATOM   875  C CG    . LEU   A 1 111 ? 38.54  -12.188 16.343 1    30.25  ?  290 LEU   A CG    1 
ATOM   876  C CD1   . LEU   A 1 111 ? 39.548 -13.295 16.735 1    30.52  ?  290 LEU   A CD1   1 
ATOM   877  C CD2   . LEU   A 1 111 ? 37.156 -12.772 16.1   1    30.42  ?  290 LEU   A CD2   1 
ATOM   878  N N     . THR   A 1 112 ? 41.296 -10.027 15.731 1    30.2   ?  291 THR   A N     1 
ATOM   879  C CA    . THR   A 1 112 ? 41.824 -9.473  14.525 1    31.98  ?  291 THR   A CA    1 
ATOM   880  C C     . THR   A 1 112 ? 41.886 -10.574 13.496 1    33.45  ?  291 THR   A C     1 
ATOM   881  O O     . THR   A 1 112 ? 42.587 -11.564 13.707 1    34.1   ?  291 THR   A O     1 
ATOM   882  C CB    . THR   A 1 112 ? 43.181 -8.857  14.857 1    33.29  ?  291 THR   A CB    1 
ATOM   883  O OG1   . THR   A 1 112 ? 42.99  -7.827  15.836 1    33.22  ?  291 THR   A OG1   1 
ATOM   884  C CG2   . THR   A 1 112 ? 43.881 -8.288  13.629 1    33.81  ?  291 THR   A CG2   1 
ATOM   885  N N     . LEU   A 1 113 ? 41.123 -10.436 12.402 1    33.55  ?  292 LEU   A N     1 
ATOM   886  C CA    . LEU   A 1 113 ? 41.098 -11.464 11.353 1    33.93  ?  292 LEU   A CA    1 
ATOM   887  C C     . LEU   A 1 113 ? 41.712 -10.98  10.073 1    35.14  ?  292 LEU   A C     1 
ATOM   888  O O     . LEU   A 1 113 ? 41.521 -9.818  9.696  1    35.44  ?  292 LEU   A O     1 
ATOM   889  C CB    . LEU   A 1 113 ? 39.66  -11.925 11.073 1    33.49  ?  292 LEU   A CB    1 
ATOM   890  C CG    . LEU   A 1 113 ? 38.907 -12.496 12.259 1    33.89  ?  292 LEU   A CG    1 
ATOM   891  C CD1   . LEU   A 1 113 ? 37.499 -12.869 11.866 1    34.23  ?  292 LEU   A CD1   1 
ATOM   892  C CD2   . LEU   A 1 113 ? 39.631 -13.72  12.847 1    33.99  ?  292 LEU   A CD2   1 
ATOM   893  N N     . ASN   A 1 114 ? 42.449 -11.864 9.381  1    35.64  ?  293 ASN   A N     1 
ATOM   894  C CA    . ASN   A 1 114 ? 43.017 -11.481 8.078  1    36.38  ?  293 ASN   A CA    1 
ATOM   895  C C     . ASN   A 1 114 ? 41.969 -11.633 6.955  1    35.81  ?  293 ASN   A C     1 
ATOM   896  O O     . ASN   A 1 114 ? 40.872 -12.187 7.191  1    35.72  ?  293 ASN   A O     1 
ATOM   897  C CB    . ASN   A 1 114 ? 44.333 -12.232 7.775  1    37.34  ?  293 ASN   A CB    1 
ATOM   898  C CG    . ASN   A 1 114 ? 44.194 -13.717 7.651  1    40.96  ?  293 ASN   A CG    1 
ATOM   899  O OD1   . ASN   A 1 114 ? 43.173 -14.243 7.223  1    41.54  ?  293 ASN   A OD1   1 
ATOM   900  N ND2   . ASN   A 1 114 ? 45.235 -14.442 8.031  1    43.69  ?  293 ASN   A ND2   1 
ATOM   901  N N     . ARG   A 1 115 ? 42.307 -11.185 5.725  1    35.48  ?  294 ARG   A N     1 
ATOM   902  C CA    . ARG   A 1 115 ? 41.399 -11.269 4.578  1    35.58  ?  294 ARG   A CA    1 
ATOM   903  C C     . ARG   A 1 115 ? 40.808 -12.658 4.365  1    36.15  ?  294 ARG   A C     1 
ATOM   904  O O     . ARG   A 1 115 ? 39.593 -12.802 4.194  1    36.8   ?  294 ARG   A O     1 
ATOM   905  C CB    . ARG   A 1 115 ? 42.058 -10.75  3.302  1    36.26  ?  294 ARG   A CB    1 
ATOM   906  C CG    . ARG   A 1 115 ? 41.059 -10.68  2.14   1    37.12  ?  294 ARG   A CG    1 
ATOM   907  C CD    . ARG   A 1 115 ? 41.616 -10.122 0.859  1    36.97  ?  294 ARG   A CD    1 
ATOM   908  N NE    . ARG   A 1 115 ? 42.233 -8.816  1.066  1    37.75  ?  294 ARG   A NE    1 
ATOM   909  C CZ    . ARG   A 1 115 ? 41.891 -7.711  0.425  1    37.37  ?  294 ARG   A CZ    1 
ATOM   910  N NH1   . ARG   A 1 115 ? 40.931 -7.738  -0.489 1    38.97  ?  294 ARG   A NH1   1 
ATOM   911  N NH2   . ARG   A 1 115 ? 42.511 -6.567  0.687  1    34.03  ?  294 ARG   A NH2   1 
ATOM   912  N N     . THR   A 1 116 ? 41.636 -13.685 4.497  1    35.65  ?  295 THR   A N     1 
ATOM   913  C CA    . THR   A 1 116 ? 41.182 -15.067 4.339  1    35.92  ?  295 THR   A CA    1 
ATOM   914  C C     . THR   A 1 116 ? 40.23  -15.47  5.443  1    35.26  ?  295 THR   A C     1 
ATOM   915  O O     . THR   A 1 116 ? 39.271 -16.18  5.165  1    35.84  ?  295 THR   A O     1 
ATOM   916  C CB    . THR   A 1 116 ? 42.391 -16.011 4.315  1    38.45  ?  295 THR   A CB    1 
ATOM   917  O OG1   . THR   A 1 116 ? 43.404 -15.468 3.469  1    40.88  ?  295 THR   A OG1   1 
ATOM   918  C CG2   . THR   A 1 116 ? 42.038 -17.406 3.872  1    38.51  ?  295 THR   A CG2   1 
ATOM   919  N N     . GLN   A 1 117 ? 40.487 -15.048 6.715  1    34.17  ?  296 GLN   A N     1 
ATOM   920  C CA    . GLN   A 1 117 ? 39.605 -15.411 7.825  1    33.4   ?  296 GLN   A CA    1 
ATOM   921  C C     . GLN   A 1 117 ? 38.277 -14.683 7.782  1    33.37  ?  296 GLN   A C     1 
ATOM   922  O O     . GLN   A 1 117 ? 37.291 -15.27  8.156  1    32.88  ?  296 GLN   A O     1 
ATOM   923  C CB    . GLN   A 1 117 ? 40.278 -15.259 9.194  1    33.7   ?  296 GLN   A CB    1 
ATOM   924  C CG    . GLN   A 1 117 ? 41.336 -16.319 9.454  1    34.8   ?  296 GLN   A CG    1 
ATOM   925  C CD    . GLN   A 1 117 ? 42.162 -15.949 10.661 1    36.82  ?  296 GLN   A CD    1 
ATOM   926  O OE1   . GLN   A 1 117 ? 42.627 -14.805 10.816 1    35.73  ?  296 GLN   A OE1   1 
ATOM   927  N NE2   . GLN   A 1 117 ? 42.358 -16.916 11.53  1    36.28  ?  296 GLN   A NE2   1 
ATOM   928  N N     . MET   A 1 118 ? 38.245 -13.424 7.338  1    34.16  ?  297 MET   A N     1 
ATOM   929  C CA    . MET   A 1 118 ? 36.999 -12.66  7.165  1    35.43  ?  297 MET   A CA    1 
ATOM   930  C C     . MET   A 1 118 ? 36.137 -13.368 6.109  1    37.3   ?  297 MET   A C     1 
ATOM   931  O O     . MET   A 1 118 ? 34.93  -13.548 6.294  1    37.49  ?  297 MET   A O     1 
ATOM   932  C CB    . MET   A 1 118 ? 37.328 -11.239 6.704  1    36.19  ?  297 MET   A CB    1 
ATOM   933  C CG    . MET   A 1 118 ? 38.025 -10.429 7.768  1    39.08  ?  297 MET   A CG    1 
ATOM   934  S SD    . MET   A 1 118 ? 36.848 -9.922  9.042  1    42.14  ?  297 MET   A SD    1 
ATOM   935  C CE    . MET   A 1 118 ? 36.395 -8.317  8.396  1    41.18  ?  297 MET   A CE    1 
ATOM   936  N N     . HIS   A 1 119 ? 36.781 -13.862 5.038  1    38.3   ?  298 HIS   A N     1 
ATOM   937  C CA    . HIS   A 1 119 ? 36.126 -14.629 3.984  1    39.17  ?  298 HIS   A CA    1 
ATOM   938  C C     . HIS   A 1 119 ? 35.505 -15.887 4.586  1    39.93  ?  298 HIS   A C     1 
ATOM   939  O O     . HIS   A 1 119 ? 34.316 -16.122 4.406  1    40.17  ?  298 HIS   A O     1 
ATOM   940  C CB    . HIS   A 1 119 ? 37.151 -14.969 2.87   1    40.1   ?  298 HIS   A CB    1 
ATOM   941  C CG    . HIS   A 1 119 ? 36.631 -15.955 1.883  1    43.07  ?  298 HIS   A CG    1 
ATOM   942  N ND1   . HIS   A 1 119 ? 36.527 -17.305 2.192  1    45.08  ?  298 HIS   A ND1   1 
ATOM   943  C CD2   . HIS   A 1 119 ? 36.145 -15.754 0.637  1    44.13  ?  298 HIS   A CD2   1 
ATOM   944  C CE1   . HIS   A 1 119 ? 35.952 -17.865 1.144  1    45.28  ?  298 HIS   A CE1   1 
ATOM   945  N NE2   . HIS   A 1 119 ? 35.726 -16.978 0.179  1    45.34  ?  298 HIS   A NE2   1 
ATOM   946  N N     . ASN   A 1 120 ? 36.292 -16.657 5.352  1    40.79  ?  299 ASN   A N     1 
ATOM   947  C CA    . ASN   A 1 120 ? 35.853 -17.912 5.963  1    42.14  ?  299 ASN   A CA    1 
ATOM   948  C C     . ASN   A 1 120 ? 34.86  -17.735 7.083  1    43.58  ?  299 ASN   A C     1 
ATOM   949  O O     . ASN   A 1 120 ? 34.104 -18.66  7.367  1    44.54  ?  299 ASN   A O     1 
ATOM   950  C CB    . ASN   A 1 120 ? 37.043 -18.72  6.465  1    43.66  ?  299 ASN   A CB    1 
ATOM   951  C CG    . ASN   A 1 120 ? 38.095 -18.98  5.416  1    47.79  ?  299 ASN   A CG    1 
ATOM   952  O OD1   . ASN   A 1 120 ? 37.836 -18.955 4.21   1    47.92  ?  299 ASN   A OD1   1 
ATOM   953  N ND2   . ASN   A 1 120 ? 39.322 -19.218 5.848  1    49.39  ?  299 ASN   A ND2   1 
ATOM   954  N N     . ALA   A 1 121 ? 34.875 -16.582 7.763  1    43.48  ?  300 ALA   A N     1 
ATOM   955  C CA    . ALA   A 1 121 ? 33.932 -16.328 8.857  1    43.39  ?  300 ALA   A CA    1 
ATOM   956  C C     . ALA   A 1 121 ? 32.495 -16.158 8.354  1    43.77  ?  300 ALA   A C     1 
ATOM   957  O O     . ALA   A 1 121 ? 31.564 -16.399 9.111  1    44.36  ?  300 ALA   A O     1 
ATOM   958  C CB    . ALA   A 1 121 ? 34.35  -15.102 9.644  1    43.26  ?  300 ALA   A CB    1 
ATOM   959  N N     . GLY   A 1 122 ? 32.317 -15.748 7.105  1    43.75  ?  301 GLY   A N     1 
ATOM   960  C CA    . GLY   A 1 122 ? 30.984 -15.564 6.546  1    44.14  ?  301 GLY   A CA    1 
ATOM   961  C C     . GLY   A 1 122 ? 30.877 -14.507 5.473  1    44.72  ?  301 GLY   A C     1 
ATOM   962  O O     . GLY   A 1 122 ? 29.837 -14.423 4.82   1    46.09  ?  301 GLY   A O     1 
ATOM   963  N N     . PHE   A 1 123 ? 31.912 -13.677 5.285  1    44.05  ?  302 PHE   A N     1 
ATOM   964  C CA    . PHE   A 1 123 ? 31.855 -12.631 4.269  1    44.91  ?  302 PHE   A CA    1 
ATOM   965  C C     . PHE   A 1 123 ? 31.805 -13.211 2.834  1    46.45  ?  302 PHE   A C     1 
ATOM   966  O O     . PHE   A 1 123 ? 31.011 -12.742 2.013  1    46.81  ?  302 PHE   A O     1 
ATOM   967  C CB    . PHE   A 1 123 ? 32.98  -11.614 4.435  1    44.72  ?  302 PHE   A CB    1 
ATOM   968  C CG    . PHE   A 1 123 ? 32.794 -10.578 5.526  1    45.69  ?  302 PHE   A CG    1 
ATOM   969  C CD1   . PHE   A 1 123 ? 32.15  -9.379  5.265  1    46.16  ?  302 PHE   A CD1   1 
ATOM   970  C CD2   . PHE   A 1 123 ? 33.332 -10.769 6.791  1    46.08  ?  302 PHE   A CD2   1 
ATOM   971  C CE1   . PHE   A 1 123 ? 32.033 -8.406  6.251  1    46.27  ?  302 PHE   A CE1   1 
ATOM   972  C CE2   . PHE   A 1 123 ? 33.224 -9.786  7.766  1    46.35  ?  302 PHE   A CE2   1 
ATOM   973  C CZ    . PHE   A 1 123 ? 32.577 -8.613  7.487  1    45.74  ?  302 PHE   A CZ    1 
ATOM   974  N N     . GLY   A 1 124 ? 32.625 -14.238 2.569  1    46.52  ?  303 GLY   A N     1 
ATOM   975  C CA    . GLY   A 1 124 ? 32.679 -14.933 1.286  1    46.42  ?  303 GLY   A CA    1 
ATOM   976  C C     . GLY   A 1 124 ? 32.908 -14.034 0.091  1    46.85  ?  303 GLY   A C     1 
ATOM   977  O O     . GLY   A 1 124 ? 33.924 -13.343 0.001  1    47.02  ?  303 GLY   A O     1 
ATOM   978  N N     . PRO   A 1 125 ? 31.922 -13.967 -0.822 1    46.9   ?  304 PRO   A N     1 
ATOM   979  C CA    . PRO   A 1 125 ? 32.075 -13.095 -2.007 1    46.77  ?  304 PRO   A CA    1 
ATOM   980  C C     . PRO   A 1 125 ? 32.102 -11.595 -1.696 1    47.27  ?  304 PRO   A C     1 
ATOM   981  O O     . PRO   A 1 125 ? 32.587 -10.817 -2.523 1    47.26  ?  304 PRO   A O     1 
ATOM   982  C CB    . PRO   A 1 125 ? 30.872 -13.459 -2.878 1    46.92  ?  304 PRO   A CB    1 
ATOM   983  C CG    . PRO   A 1 125 ? 29.868 -14.02  -1.929 1    47.27  ?  304 PRO   A CG    1 
ATOM   984  C CD    . PRO   A 1 125 ? 30.644 -14.704 -0.835 1    45.79  ?  304 PRO   A CD    1 
ATOM   985  N N     . LEU   A 1 126 ? 31.583 -11.186 -0.512 1    47.16  ?  305 LEU   A N     1 
ATOM   986  C CA    . LEU   A 1 126 ? 31.579 -9.785  -0.065 1    47.33  ?  305 LEU   A CA    1 
ATOM   987  C C     . LEU   A 1 126 ? 32.974 -9.273  0.283  1    46.45  ?  305 LEU   A C     1 
ATOM   988  O O     . LEU   A 1 126 ? 33.195 -8.065  0.272  1    47.06  ?  305 LEU   A O     1 
ATOM   989  C CB    . LEU   A 1 126 ? 30.741 -9.646  1.223  1    48.13  ?  305 LEU   A CB    1 
ATOM   990  C CG    . LEU   A 1 126 ? 29.24  -9.774  1.113  1    50.22  ?  305 LEU   A CG    1 
ATOM   991  C CD1   . LEU   A 1 126 ? 28.629 -9.916  2.49   1    51.06  ?  305 LEU   A CD1   1 
ATOM   992  C CD2   . LEU   A 1 126 ? 28.657 -8.565  0.417  1    50.82  ?  305 LEU   A CD2   1 
ATOM   993  N N     . THR   A 1 127 ? 33.884 -10.176 0.667  1    44.92  ?  306 THR   A N     1 
ATOM   994  C CA    . THR   A 1 127 ? 35.212 -9.872  1.188  1    43.34  ?  306 THR   A CA    1 
ATOM   995  C C     . THR   A 1 127 ? 35.99  -8.775  0.45   1    43.28  ?  306 THR   A C     1 
ATOM   996  O O     . THR   A 1 127 ? 36.341 -7.78   1.085  1    42.69  ?  306 THR   A O     1 
ATOM   997  C CB    . THR   A 1 127 ? 36.037 -11.143 1.315  1    43.11  ?  306 THR   A CB    1 
ATOM   998  O OG1   . THR   A 1 127 ? 35.272 -12.128 2.027  1    42.44  ?  306 THR   A OG1   1 
ATOM   999  C CG2   . THR   A 1 127 ? 37.371 -10.899 2.01   1    43.2   ?  306 THR   A CG2   1 
ATOM   1000 N N     . ASP   A 1 128 ? 36.239 -8.905  -0.866 1    43.96  ?  307 ASP   A N     1 
ATOM   1001 C CA    . ASP   A 1 128 ? 37.052 -7.906  -1.577 1    44.46  ?  307 ASP   A CA    1 
ATOM   1002 C C     . ASP   A 1 128 ? 36.396 -6.547  -1.669 1    43.58  ?  307 ASP   A C     1 
ATOM   1003 O O     . ASP   A 1 128 ? 37.103 -5.549  -1.645 1    43.84  ?  307 ASP   A O     1 
ATOM   1004 C CB    . ASP   A 1 128 ? 37.503 -8.406  -2.951 1    48.1   ?  307 ASP   A CB    1 
ATOM   1005 C CG    . ASP   A 1 128 ? 38.448 -9.591  -2.844 1    55.37  ?  307 ASP   A CG    1 
ATOM   1006 O OD1   . ASP   A 1 128 ? 39.388 -9.532  -2.003 1    55.22  ?  307 ASP   A OD1   1 
ATOM   1007 O OD2   . ASP   A 1 128 ? 38.241 -10.587 -3.587 1    59.32  ?  307 ASP   A OD2   1 
ATOM   1008 N N     . LEU   A 1 129 ? 35.067 -6.486  -1.719 1    43.01  ?  308 LEU   A N     1 
ATOM   1009 C CA    . LEU   A 1 129 ? 34.362 -5.204  -1.737 1    42.95  ?  308 LEU   A CA    1 
ATOM   1010 C C     . LEU   A 1 129 ? 34.469 -4.517  -0.359 1    40.89  ?  308 LEU   A C     1 
ATOM   1011 O O     . LEU   A 1 129 ? 34.761 -3.326  -0.273 1    40.81  ?  308 LEU   A O     1 
ATOM   1012 C CB    . LEU   A 1 129 ? 32.892 -5.43   -2.135 1    44.66  ?  308 LEU   A CB    1 
ATOM   1013 C CG    . LEU   A 1 129 ? 32.672 -5.95   -3.575 1    47.4   ?  308 LEU   A CG    1 
ATOM   1014 C CD1   . LEU   A 1 129 ? 31.197 -6.021  -3.903 1    48.21  ?  308 LEU   A CD1   1 
ATOM   1015 C CD2   . LEU   A 1 129 ? 33.429 -5.08   -4.626 1    48.55  ?  308 LEU   A CD2   1 
ATOM   1016 N N     . VAL   A 1 130 ? 34.34  -5.294  0.713  1    39.3   ?  309 VAL   A N     1 
ATOM   1017 C CA    . VAL   A 1 130 ? 34.474 -4.768  2.073  1    38.44  ?  309 VAL   A CA    1 
ATOM   1018 C C     . VAL   A 1 130 ? 35.896 -4.248  2.29   1    37.33  ?  309 VAL   A C     1 
ATOM   1019 O O     . VAL   A 1 130 ? 36.076 -3.089  2.659  1    36.01  ?  309 VAL   A O     1 
ATOM   1020 C CB    . VAL   A 1 130 ? 34.041 -5.834  3.095  1    39.12  ?  309 VAL   A CB    1 
ATOM   1021 C CG1   . VAL   A 1 130 ? 34.421 -5.447  4.526  1    40.1   ?  309 VAL   A CG1   1 
ATOM   1022 C CG2   . VAL   A 1 130 ? 32.551 -6.088  2.98   1    39.32  ?  309 VAL   A CG2   1 
ATOM   1023 N N     . PHE   A 1 131 ? 36.907 -5.04   1.888  1    37.66  ?  310 PHE   A N     1 
ATOM   1024 C CA    . PHE   A 1 131 ? 38.302 -4.605  2.019  1    37.74  ?  310 PHE   A CA    1 
ATOM   1025 C C     . PHE   A 1 131 ? 38.663 -3.427  1.1    1    36.92  ?  310 PHE   A C     1 
ATOM   1026 O O     . PHE   A 1 131 ? 39.407 -2.535  1.517  1    36.38  ?  310 PHE   A O     1 
ATOM   1027 C CB    . PHE   A 1 131 ? 39.263 -5.784  1.848  1    38.44  ?  310 PHE   A CB    1 
ATOM   1028 C CG    . PHE   A 1 131 ? 39.39  -6.668  3.072  1    39.52  ?  310 PHE   A CG    1 
ATOM   1029 C CD1   . PHE   A 1 131 ? 38.381 -7.547  3.42   1    40.31  ?  310 PHE   A CD1   1 
ATOM   1030 C CD2   . PHE   A 1 131 ? 40.527 -6.631  3.86   1    40.62  ?  310 PHE   A CD2   1 
ATOM   1031 C CE1   . PHE   A 1 131 ? 38.507 -8.369  4.533  1    41.16  ?  310 PHE   A CE1   1 
ATOM   1032 C CE2   . PHE   A 1 131 ? 40.644 -7.446  4.975  1    41.11  ?  310 PHE   A CE2   1 
ATOM   1033 C CZ    . PHE   A 1 131 ? 39.633 -8.307  5.303  1    40.96  ?  310 PHE   A CZ    1 
ATOM   1034 N N     . ALA   A 1 132 ? 38.071 -3.355  -0.101 1    37.47  ?  311 ALA   A N     1 
ATOM   1035 C CA    . ALA   A 1 132 ? 38.311 -2.225  -1.002 1    38.67  ?  311 ALA   A CA    1 
ATOM   1036 C C     . ALA   A 1 132 ? 37.735 -0.958  -0.368 1    39.72  ?  311 ALA   A C     1 
ATOM   1037 O O     . ALA   A 1 132 ? 38.441 0.063   -0.283 1    40.02  ?  311 ALA   A O     1 
ATOM   1038 C CB    . ALA   A 1 132 ? 37.684 -2.479  -2.372 1    38.78  ?  311 ALA   A CB    1 
ATOM   1039 N N     . PHE   A 1 133 ? 36.504 -1.059  0.196  1    39.78  ?  312 PHE   A N     1 
ATOM   1040 C CA    . PHE   A 1 133 ? 35.868 0.053   0.898  1    40.15  ?  312 PHE   A CA    1 
ATOM   1041 C C     . PHE   A 1 133 ? 36.737 0.516   2.069  1    39.65  ?  312 PHE   A C     1 
ATOM   1042 O O     . PHE   A 1 133 ? 36.925 1.72    2.257  1    39.76  ?  312 PHE   A O     1 
ATOM   1043 C CB    . PHE   A 1 133 ? 34.476 -0.347  1.403  1    41.06  ?  312 PHE   A CB    1 
ATOM   1044 C CG    . PHE   A 1 133 ? 33.759 0.779   2.126  1    42.35  ?  312 PHE   A CG    1 
ATOM   1045 C CD1   . PHE   A 1 133 ? 33.068 1.749   1.42   1    43.27  ?  312 PHE   A CD1   1 
ATOM   1046 C CD2   . PHE   A 1 133 ? 33.789 0.87    3.507  1    43.29  ?  312 PHE   A CD2   1 
ATOM   1047 C CE1   . PHE   A 1 133 ? 32.416 2.787   2.083  1    44.22  ?  312 PHE   A CE1   1 
ATOM   1048 C CE2   . PHE   A 1 133 ? 33.159 1.923   4.164  1    44.17  ?  312 PHE   A CE2   1 
ATOM   1049 C CZ    . PHE   A 1 133 ? 32.474 2.873   3.45   1    43.93  ?  312 PHE   A CZ    1 
ATOM   1050 N N     . ALA   A 1 134 ? 37.304 -0.431  2.84   1    39.29  ?  313 ALA   A N     1 
ATOM   1051 C CA    . ALA   A 1 134 ? 38.198 -0.076  3.945  1    40.06  ?  313 ALA   A CA    1 
ATOM   1052 C C     . ALA   A 1 134 ? 39.413 0.732   3.443  1    41.8   ?  313 ALA   A C     1 
ATOM   1053 O O     . ALA   A 1 134 ? 39.78  1.753   4.032  1    41.51  ?  313 ALA   A O     1 
ATOM   1054 C CB    . ALA   A 1 134 ? 38.656 -1.33   4.667  1    39.52  ?  313 ALA   A CB    1 
ATOM   1055 N N     . ASN   A 1 135 ? 39.994 0.312   2.32   1    43.76  ?  314 ASN   A N     1 
ATOM   1056 C CA    . ASN   A 1 135 ? 41.118 1.044   1.737  1    45.58  ?  314 ASN   A CA    1 
ATOM   1057 C C     . ASN   A 1 135 ? 40.717 2.434   1.248  1    48.78  ?  314 ASN   A C     1 
ATOM   1058 O O     . ASN   A 1 135 ? 41.473 3.374   1.453  1    50.03  ?  314 ASN   A O     1 
ATOM   1059 C CB    . ASN   A 1 135 ? 41.805 0.228   0.68   1    44.63  ?  314 ASN   A CB    1 
ATOM   1060 C CG    . ASN   A 1 135 ? 42.771 -0.724  1.315  1    45.06  ?  314 ASN   A CG    1 
ATOM   1061 O OD1   . ASN   A 1 135 ? 43.809 -0.318  1.882  1    44.32  ?  314 ASN   A OD1   1 
ATOM   1062 N ND2   . ASN   A 1 135 ? 42.434 -2.007  1.259  1    45.21  ?  314 ASN   A ND2   1 
ATOM   1063 N N     . GLN   A 1 136 ? 39.516 2.593   0.704  1    50.37  ?  315 GLN   A N     1 
ATOM   1064 C CA    . GLN   A 1 136 ? 39.032 3.914   0.269  1    52.43  ?  315 GLN   A CA    1 
ATOM   1065 C C     . GLN   A 1 136 ? 38.741 4.845   1.448  1    54.39  ?  315 GLN   A C     1 
ATOM   1066 O O     . GLN   A 1 136 ? 38.835 6.064   1.323  1    55.22  ?  315 GLN   A O     1 
ATOM   1067 C CB    . GLN   A 1 136 ? 37.766 3.773   -0.587 1    53.91  ?  315 GLN   A CB    1 
ATOM   1068 N N     . LEU   A 1 137 ? 38.361 4.266   2.587  1    54.79  ?  316 LEU   A N     1 
ATOM   1069 C CA    . LEU   A 1 137 ? 38.005 4.955   3.807  1    55.26  ?  316 LEU   A CA    1 
ATOM   1070 C C     . LEU   A 1 137 ? 39.233 5.491   4.518  1    56.68  ?  316 LEU   A C     1 
ATOM   1071 O O     . LEU   A 1 137 ? 39.194 6.577   5.075  1    56.76  ?  316 LEU   A O     1 
ATOM   1072 C CB    . LEU   A 1 137 ? 37.305 3.92    4.692  1    55.23  ?  316 LEU   A CB    1 
ATOM   1073 C CG    . LEU   A 1 137 ? 36.486 4.41    5.846  1    56.18  ?  316 LEU   A CG    1 
ATOM   1074 C CD1   . LEU   A 1 137 ? 35.335 5.272   5.355  1    56.34  ?  316 LEU   A CD1   1 
ATOM   1075 C CD2   . LEU   A 1 137 ? 36.01  3.22    6.703  1    56.41  ?  316 LEU   A CD2   1 
ATOM   1076 N N     . LEU   A 1 138 ? 40.304 4.708   4.546  1    58.15  ?  317 LEU   A N     1 
ATOM   1077 C CA    . LEU   A 1 138 ? 41.552 5.023   5.233  1    59.99  ?  317 LEU   A CA    1 
ATOM   1078 C C     . LEU   A 1 138 ? 42.148 6.418   4.894  1    61.09  ?  317 LEU   A C     1 
ATOM   1079 O O     . LEU   A 1 138 ? 42.354 7.192   5.832  1    61.22  ?  317 LEU   A O     1 
ATOM   1080 C CB    . LEU   A 1 138 ? 42.569 3.894   4.994  1    60.72  ?  317 LEU   A CB    1 
ATOM   1081 C CG    . LEU   A 1 138 ? 43.826 3.928   5.826  1    63.14  ?  317 LEU   A CG    1 
ATOM   1082 C CD1   . LEU   A 1 138 ? 43.65  3.123   7.109  1    63.75  ?  317 LEU   A CD1   1 
ATOM   1083 C CD2   . LEU   A 1 138 ? 44.995 3.389   5.029  1    64.03  ?  317 LEU   A CD2   1 
ATOM   1084 N N     . PRO   A 1 139 ? 42.389 6.8     3.61   1    61.59  ?  318 PRO   A N     1 
ATOM   1085 C CA    . PRO   A 1 139 ? 42.969 8.127   3.337  1    61.99  ?  318 PRO   A CA    1 
ATOM   1086 C C     . PRO   A 1 139 ? 42.099 9.305   3.742  1    62.42  ?  318 PRO   A C     1 
ATOM   1087 O O     . PRO   A 1 139 ? 42.63  10.389  3.975  1    62.55  ?  318 PRO   A O     1 
ATOM   1088 C CB    . PRO   A 1 139 ? 43.174 8.113   1.82   1    62.5   ?  318 PRO   A CB    1 
ATOM   1089 C CG    . PRO   A 1 139 ? 42.194 7.132   1.323  1    62.86  ?  318 PRO   A CG    1 
ATOM   1090 C CD    . PRO   A 1 139 ? 42.221 6.05    2.354  1    61.13  ?  318 PRO   A CD    1 
ATOM   1091 N N     . LEU   A 1 140 ? 40.777 9.101   3.842  1    62.38  ?  319 LEU   A N     1 
ATOM   1092 C CA    . LEU   A 1 140 ? 39.851 10.157  4.264  1    62.69  ?  319 LEU   A CA    1 
ATOM   1093 C C     . LEU   A 1 140 ? 40.198 10.746  5.638  1    62.43  ?  319 LEU   A C     1 
ATOM   1094 O O     . LEU   A 1 140 ? 39.799 11.871  5.93   1    62.9   ?  319 LEU   A O     1 
ATOM   1095 C CB    . LEU   A 1 140 ? 38.393 9.674   4.23   1    63.16  ?  319 LEU   A CB    1 
ATOM   1096 C CG    . LEU   A 1 140 ? 37.586 10.046  2.976  1    65.32  ?  319 LEU   A CG    1 
ATOM   1097 C CD1   . LEU   A 1 140 ? 38.24  9.521   1.707  1    66.14  ?  319 LEU   A CD1   1 
ATOM   1098 C CD2   . LEU   A 1 140 ? 36.169 9.523   3.063  1    66.16  ?  319 LEU   A CD2   1 
ATOM   1099 N N     . GLU   A 1 141 ? 40.942 9.991   6.464  1    61.71  ?  320 GLU   A N     1 
ATOM   1100 C CA    . GLU   A 1 141 ? 41.412 10.378  7.789  1    61.68  ?  320 GLU   A CA    1 
ATOM   1101 C C     . GLU   A 1 141 ? 40.291 10.862  8.696  1    61.09  ?  320 GLU   A C     1 
ATOM   1102 O O     . GLU   A 1 141 ? 40.451 11.854  9.407  1    61.86  ?  320 GLU   A O     1 
ATOM   1103 C CB    . GLU   A 1 141 ? 42.553 11.403  7.69   1    63.92  ?  320 GLU   A CB    1 
ATOM   1104 C CG    . GLU   A 1 141 ? 43.722 11.079  8.605  1    68.86  ?  320 GLU   A CG    1 
ATOM   1105 C CD    . GLU   A 1 141 ? 44.935 11.973  8.431  1    74.96  ?  320 GLU   A CD    1 
ATOM   1106 O OE1   . GLU   A 1 141 ? 45.225 12.368  7.277  1    75.85  ?  320 GLU   A OE1   1 
ATOM   1107 O OE2   . GLU   A 1 141 ? 45.599 12.274  9.45   1    76.29  ?  320 GLU   A OE2   1 
ATOM   1108 N N     . MET   A 1 142 ? 39.156 10.167  8.671  1    59.63  ?  321 MET   A N     1 
ATOM   1109 C CA    . MET   A 1 142 ? 38.01  10.555  9.476  1    59.13  ?  321 MET   A CA    1 
ATOM   1110 C C     . MET   A 1 142 ? 38.225 10.364  10.957 1    57.94  ?  321 MET   A C     1 
ATOM   1111 O O     . MET   A 1 142 ? 38.953 9.468   11.37  1    57.68  ?  321 MET   A O     1 
ATOM   1112 C CB    . MET   A 1 142 ? 36.756 9.805   9.028  1    60.2   ?  321 MET   A CB    1 
ATOM   1113 C CG    . MET   A 1 142 ? 36.371 10.115  7.623  1    62.64  ?  321 MET   A CG    1 
ATOM   1114 S SD    . MET   A 1 142 ? 35.179 8.927   7.014  1    68.98  ?  321 MET   A SD    1 
ATOM   1115 C CE    . MET   A 1 142 ? 33.78  9.378   7.973  1    68.23  ?  321 MET   A CE    1 
ATOM   1116 N N     . ASP   A 1 143 ? 37.604 11.232  11.756 1    56.97  ?  322 ASP   A N     1 
ATOM   1117 C CA    . ASP   A 1 143 ? 37.673 11.13   13.205 1    56.32  ?  322 ASP   A CA    1 
ATOM   1118 C C     . ASP   A 1 143 ? 36.324 10.591  13.773 1    54.99  ?  322 ASP   A C     1 
ATOM   1119 O O     . ASP   A 1 143 ? 35.478 10.131  13.002 1    55.33  ?  322 ASP   A O     1 
ATOM   1120 C CB    . ASP   A 1 143 ? 38.159 12.452  13.846 1    58.07  ?  322 ASP   A CB    1 
ATOM   1121 C CG    . ASP   A 1 143 ? 37.276 13.657  13.592 1    63.19  ?  322 ASP   A CG    1 
ATOM   1122 O OD1   . ASP   A 1 143 ? 36.358 13.552  12.765 1    63.64  ?  322 ASP   A OD1   1 
ATOM   1123 O OD2   . ASP   A 1 143 ? 37.507 14.709  14.231 1    65.78  ?  322 ASP   A OD2   1 
ATOM   1124 N N     . ASP   A 1 144 ? 36.146 10.583  15.099 1    53.37  ?  323 ASP   A N     1 
ATOM   1125 C CA    . ASP   A 1 144 ? 34.935 10.072  15.719 1    52.5   ?  323 ASP   A CA    1 
ATOM   1126 C C     . ASP   A 1 144 ? 33.714 10.879  15.275 1    50.84  ?  323 ASP   A C     1 
ATOM   1127 O O     . ASP   A 1 144 ? 32.668 10.31   14.97  1    50.5   ?  323 ASP   A O     1 
ATOM   1128 C CB    . ASP   A 1 144 ? 35.074 10.102  17.248 1    54.64  ?  323 ASP   A CB    1 
ATOM   1129 C CG    . ASP   A 1 144 ? 36.305 9.393   17.794 1    60.44  ?  323 ASP   A CG    1 
ATOM   1130 O OD1   . ASP   A 1 144 ? 36.949 8.643   17.027 1    62.04  ?  323 ASP   A OD1   1 
ATOM   1131 O OD2   . ASP   A 1 144 ? 36.621 9.585   18.986 1    62.41  ?  323 ASP   A OD2   1 
ATOM   1132 N N     . ALA   A 1 145 ? 33.864 12.199  15.2   1    49.94  ?  324 ALA   A N     1 
ATOM   1133 C CA    . ALA   A 1 145 ? 32.772 13.078  14.798 1    49.6   ?  324 ALA   A CA    1 
ATOM   1134 C C     . ALA   A 1 145 ? 32.227 12.746  13.41  1    48.35  ?  324 ALA   A C     1 
ATOM   1135 O O     . ALA   A 1 145 ? 31.028 12.558  13.269 1    48.33  ?  324 ALA   A O     1 
ATOM   1136 C CB    . ALA   A 1 145 ? 33.202 14.543  14.885 1    49.68  ?  324 ALA   A CB    1 
ATOM   1137 N N     . GLU   A 1 146 ? 33.112 12.562  12.427 1    47.49  ?  325 GLU   A N     1 
ATOM   1138 C CA    . GLU   A 1 146 ? 32.76  12.282  11.044 1    47.44  ?  325 GLU   A CA    1 
ATOM   1139 C C     . GLU   A 1 146 ? 32.219 10.878  10.828 1    46.37  ?  325 GLU   A C     1 
ATOM   1140 O O     . GLU   A 1 146 ? 31.223 10.718  10.116 1    46.2   ?  325 GLU   A O     1 
ATOM   1141 C CB    . GLU   A 1 146 ? 33.954 12.587  10.135 1    51.17  ?  325 GLU   A CB    1 
ATOM   1142 C CG    . GLU   A 1 146 ? 34.301 14.071  10.155 1    58.57  ?  325 GLU   A CG    1 
ATOM   1143 C CD    . GLU   A 1 146 ? 35.677 14.431  9.63   1    69.16  ?  325 GLU   A CD    1 
ATOM   1144 O OE1   . GLU   A 1 146 ? 36.52  13.515  9.489  1    71.85  ?  325 GLU   A OE1   1 
ATOM   1145 O OE2   . GLU   A 1 146 ? 35.913 15.629  9.359  1    72.42  ?  325 GLU   A OE2   1 
ATOM   1146 N N     . THR   A 1 147 ? 32.835 9.862   11.469 1    45.09  ?  326 THR   A N     1 
ATOM   1147 C CA    . THR   A 1 147 ? 32.348 8.479   11.402 1    43.64  ?  326 THR   A CA    1 
ATOM   1148 C C     . THR   A 1 147 ? 30.95  8.4     12.009 1    42.6   ?  326 THR   A C     1 
ATOM   1149 O O     . THR   A 1 147 ? 30.056 7.793   11.42  1    42.57  ?  326 THR   A O     1 
ATOM   1150 C CB    . THR   A 1 147 ? 33.323 7.513   12.096 1    44.19  ?  326 THR   A CB    1 
ATOM   1151 O OG1   . THR   A 1 147 ? 34.606 7.642   11.488 1    45.18  ?  326 THR   A OG1   1 
ATOM   1152 C CG2   . THR   A 1 147 ? 32.873 6.058   11.99  1    44.35  ?  326 THR   A CG2   1 
ATOM   1153 N N     . GLY   A 1 148 ? 30.772 9.044   13.163 1    41.91  ?  327 GLY   A N     1 
ATOM   1154 C CA    . GLY   A 1 148 ? 29.49  9.115   13.853 1    41.55  ?  327 GLY   A CA    1 
ATOM   1155 C C     . GLY   A 1 148 ? 28.426 9.79    13.01  1    41.22  ?  327 GLY   A C     1 
ATOM   1156 O O     . GLY   A 1 148 ? 27.309 9.287   12.914 1    41.37  ?  327 GLY   A O     1 
ATOM   1157 N N     . LEU   A 1 149 ? 28.772 10.912  12.35  1    40.83  ?  328 LEU   A N     1 
ATOM   1158 C CA    . LEU   A 1 149 ? 27.83  11.63   11.481 1    41     ?  328 LEU   A CA    1 
ATOM   1159 C C     . LEU   A 1 149 ? 27.47  10.817  10.246 1    40.62  ?  328 LEU   A C     1 
ATOM   1160 O O     . LEU   A 1 149 ? 26.316 10.808  9.846  1    40.6   ?  328 LEU   A O     1 
ATOM   1161 C CB    . LEU   A 1 149 ? 28.37  13.012  11.078 1    41.18  ?  328 LEU   A CB    1 
ATOM   1162 C CG    . LEU   A 1 149 ? 28.318 14.068  12.184 1    42.3   ?  328 LEU   A CG    1 
ATOM   1163 C CD1   . LEU   A 1 149 ? 29.251 15.242  11.862 1    43.25  ?  328 LEU   A CD1   1 
ATOM   1164 C CD2   . LEU   A 1 149 ? 26.921 14.531  12.429 1    41.78  ?  328 LEU   A CD2   1 
ATOM   1165 N N     . LEU   A 1 150 ? 28.434 10.088  9.685  1    40.36  ?  329 LEU   A N     1 
ATOM   1166 C CA    . LEU   A 1 150 ? 28.193 9.231   8.528  1    40.89  ?  329 LEU   A CA    1 
ATOM   1167 C C     . LEU   A 1 150 ? 27.235 8.089   8.88   1    39.46  ?  329 LEU   A C     1 
ATOM   1168 O O     . LEU   A 1 150 ? 26.416 7.691   8.046  1    39.23  ?  329 LEU   A O     1 
ATOM   1169 C CB    . LEU   A 1 150 ? 29.513 8.647   8.038  1    42.21  ?  329 LEU   A CB    1 
ATOM   1170 C CG    . LEU   A 1 150 ? 29.768 8.754   6.554  1    45.11  ?  329 LEU   A CG    1 
ATOM   1171 C CD1   . LEU   A 1 150 ? 30.118 10.183  6.174  1    46.18  ?  329 LEU   A CD1   1 
ATOM   1172 C CD2   . LEU   A 1 150 ? 30.914 7.828   6.138  1    45.8   ?  329 LEU   A CD2   1 
ATOM   1173 N N     . SER   A 1 151 ? 27.375 7.546   10.107 1    38.03  ?  330 SER   A N     1 
ATOM   1174 C CA    . SER   A 1 151 ? 26.523 6.495   10.617 1    37.47  ?  330 SER   A CA    1 
ATOM   1175 C C     . SER   A 1 151 ? 25.13  7.033   10.826 1    36.18  ?  330 SER   A C     1 
ATOM   1176 O O     . SER   A 1 151 ? 24.194 6.347   10.484 1    36.2   ?  330 SER   A O     1 
ATOM   1177 C CB    . SER   A 1 151 ? 27.059 5.954   11.939 1    38.61  ?  330 SER   A CB    1 
ATOM   1178 O OG    . SER   A 1 151 ? 28.289 5.283   11.732 1    41.01  ?  330 SER   A OG    1 
ATOM   1179 N N     . ALA   A 1 152 ? 24.989 8.243   11.393 1    35.41  ?  331 ALA   A N     1 
ATOM   1180 C CA    . ALA   A 1 152 ? 23.677 8.848   11.648 1    35.25  ?  331 ALA   A CA    1 
ATOM   1181 C C     . ALA   A 1 152 ? 22.966 9.203   10.338 1    35.82  ?  331 ALA   A C     1 
ATOM   1182 O O     . ALA   A 1 152 ? 21.749 9.058   10.261 1    36.16  ?  331 ALA   A O     1 
ATOM   1183 C CB    . ALA   A 1 152 ? 23.821 10.085  12.53  1    34.48  ?  331 ALA   A CB    1 
ATOM   1184 N N     . ILE   A 1 153 ? 23.717 9.652   9.319  1    35.37  ?  332 ILE   A N     1 
ATOM   1185 C CA    . ILE   A 1 153 ? 23.156 9.994   8.009  1    36.55  ?  332 ILE   A CA    1 
ATOM   1186 C C     . ILE   A 1 153 ? 22.655 8.716   7.296  1    37.14  ?  332 ILE   A C     1 
ATOM   1187 O O     . ILE   A 1 153 ? 21.615 8.74    6.656  1    36.95  ?  332 ILE   A O     1 
ATOM   1188 C CB    . ILE   A 1 153 ? 24.178 10.829  7.18   1    37.59  ?  332 ILE   A CB    1 
ATOM   1189 C CG1   . ILE   A 1 153 ? 24.339 12.233  7.792  1    38.42  ?  332 ILE   A CG1   1 
ATOM   1190 C CG2   . ILE   A 1 153 ? 23.769 10.942  5.696  1    38.42  ?  332 ILE   A CG2   1 
ATOM   1191 C CD1   . ILE   A 1 153 ? 25.539 12.979  7.287  1    39.8   ?  332 ILE   A CD1   1 
ATOM   1192 N N     . CYS   A 1 154 ? 23.379 7.597   7.455  1    37.76  ?  333 CYS   A N     1 
ATOM   1193 C CA    A CYS   A 1 154 ? 23.015 6.285   6.903  0.47 38.21  ?  333 CYS   A CA    1 
ATOM   1194 C CA    B CYS   A 1 154 ? 22.983 6.338   6.857  0.53 38.48  ?  333 CYS   A CA    1 
ATOM   1195 C C     . CYS   A 1 154 ? 21.731 5.766   7.545  1    38.4   ?  333 CYS   A C     1 
ATOM   1196 O O     . CYS   A 1 154 ? 20.905 5.118   6.885  1    38.62  ?  333 CYS   A O     1 
ATOM   1197 C CB    A CYS   A 1 154 ? 24.145 5.28    7.118  0.47 38.88  ?  333 CYS   A CB    1 
ATOM   1198 C CB    B CYS   A 1 154 ? 24.143 5.35    6.891  0.53 39.83  ?  333 CYS   A CB    1 
ATOM   1199 S SG    A CYS   A 1 154 ? 25.659 5.643   6.206  0.47 42.74  ?  333 CYS   A SG    1 
ATOM   1200 S SG    B CYS   A 1 154 ? 23.694 3.671   6.393  0.53 45.97  ?  333 CYS   A SG    1 
ATOM   1201 N N     . LEU   A 1 155 ? 21.612 5.952   8.862  1    37.55  ?  334 LEU   A N     1 
ATOM   1202 C CA    . LEU   A 1 155 ? 20.465 5.446   9.598  1    37.24  ?  334 LEU   A CA    1 
ATOM   1203 C C     . LEU   A 1 155 ? 19.226 6.3     9.333  1    37.17  ?  334 LEU   A C     1 
ATOM   1204 O O     . LEU   A 1 155 ? 18.145 5.771   9.061  1    36.96  ?  334 LEU   A O     1 
ATOM   1205 C CB    . LEU   A 1 155 ? 20.801 5.428   11.1   1    37.34  ?  334 LEU   A CB    1 
ATOM   1206 C CG    . LEU   A 1 155 ? 19.633 5.139   12.045 1    39.06  ?  334 LEU   A CG    1 
ATOM   1207 C CD1   . LEU   A 1 155 ? 19.174 3.704   11.898 1    39.48  ?  334 LEU   A CD1   1 
ATOM   1208 C CD2   . LEU   A 1 155 ? 20.012 5.438   13.487 1    39.61  ?  334 LEU   A CD2   1 
ATOM   1209 N N     . ILE   A 1 156 ? 19.376 7.611   9.461  1    37.73  ?  335 ILE   A N     1 
ATOM   1210 C CA    . ILE   A 1 156 ? 18.261 8.539   9.346  1    39.67  ?  335 ILE   A CA    1 
ATOM   1211 C C     . ILE   A 1 156 ? 18.123 8.939   7.901  1    41.31  ?  335 ILE   A C     1 
ATOM   1212 O O     . ILE   A 1 156 ? 18.699 9.912   7.46   1    42.47  ?  335 ILE   A O     1 
ATOM   1213 C CB    . ILE   A 1 156 ? 18.48  9.701   10.346 1    40.47  ?  335 ILE   A CB    1 
ATOM   1214 C CG1   . ILE   A 1 156 ? 18.537 9.102   11.795 1    41.09  ?  335 ILE   A CG1   1 
ATOM   1215 C CG2   . ILE   A 1 156 ? 17.395 10.8    10.222 1    40.86  ?  335 ILE   A CG2   1 
ATOM   1216 C CD1   . ILE   A 1 156 ? 18.85  10.051  12.866 1    42.14  ?  335 ILE   A CD1   1 
ATOM   1217 N N     . CYS   A 1 157 ? 17.457 8.094   7.141  1    41.47  ?  336 CYS   A N     1 
ATOM   1218 C CA    . CYS   A 1 157 ? 17.298 8.253   5.718  1    43.3   ?  336 CYS   A CA    1 
ATOM   1219 C C     . CYS   A 1 157 ? 15.82  8.067   5.393  1    44.16  ?  336 CYS   A C     1 
ATOM   1220 O O     . CYS   A 1 157 ? 15.215 7.067   5.781  1    43.11  ?  336 CYS   A O     1 
ATOM   1221 C CB    . CYS   A 1 157 ? 18.165 7.22    5.006  1    45.58  ?  336 CYS   A CB    1 
ATOM   1222 S SG    . CYS   A 1 157 ? 17.846 7.075   3.234  1    53.28  ?  336 CYS   A SG    1 
ATOM   1223 N N     . GLY   A 1 158 ? 15.249 9.047   4.706  1    45.63  ?  337 GLY   A N     1 
ATOM   1224 C CA    . GLY   A 1 158 ? 13.834 9.03    4.374  1    47.01  ?  337 GLY   A CA    1 
ATOM   1225 C C     . GLY   A 1 158 ? 13.459 8.115   3.233  1    48.43  ?  337 GLY   A C     1 
ATOM   1226 O O     . GLY   A 1 158 ? 12.275 7.793   3.074  1    49.31  ?  337 GLY   A O     1 
ATOM   1227 N N     . ASP   A 1 159 ? 14.447 7.68    2.425  1    48.56  ?  338 ASP   A N     1 
ATOM   1228 C CA    . ASP   A 1 159 ? 14.127 6.868   1.259  1    49.35  ?  338 ASP   A CA    1 
ATOM   1229 C C     . ASP   A 1 159 ? 13.836 5.396   1.568  1    49.16  ?  338 ASP   A C     1 
ATOM   1230 O O     . ASP   A 1 159 ? 13.507 4.66    0.636  1    49.94  ?  338 ASP   A O     1 
ATOM   1231 C CB    . ASP   A 1 159 ? 15.178 7.008   0.145  1    52.23  ?  338 ASP   A CB    1 
ATOM   1232 C CG    . ASP   A 1 159 ? 16.534 6.361   0.374  1    60.02  ?  338 ASP   A CG    1 
ATOM   1233 O OD1   . ASP   A 1 159 ? 16.586 5.298   1.038  1    61.25  ?  338 ASP   A OD1   1 
ATOM   1234 O OD2   . ASP   A 1 159 ? 17.544 6.894   -0.153 1    62.93  ?  338 ASP   A OD2   1 
ATOM   1235 N N     . ARG   A 1 160 ? 13.916 4.967   2.831  1    48.29  ?  339 ARG   A N     1 
ATOM   1236 C CA    . ARG   A 1 160 ? 13.658 3.562   3.166  1    48.87  ?  339 ARG   A CA    1 
ATOM   1237 C C     . ARG   A 1 160 ? 12.217 3.156   2.899  1    50.72  ?  339 ARG   A C     1 
ATOM   1238 O O     . ARG   A 1 160 ? 11.298 3.936   3.157  1    51.07  ?  339 ARG   A O     1 
ATOM   1239 C CB    . ARG   A 1 160 ? 14.045 3.245   4.618  1    48.85  ?  339 ARG   A CB    1 
ATOM   1240 C CG    . ARG   A 1 160 ? 15.416 3.763   5.024  1    49.29  ?  339 ARG   A CG    1 
ATOM   1241 C CD    . ARG   A 1 160 ? 16.523 3.183   4.188  1    51.49  ?  339 ARG   A CD    1 
ATOM   1242 N NE    . ARG   A 1 160 ? 17.819 3.363   4.835  1    53.77  ?  339 ARG   A NE    1 
ATOM   1243 C CZ    . ARG   A 1 160 ? 18.931 2.727   4.482  1    54.02  ?  339 ARG   A CZ    1 
ATOM   1244 N NH1   . ARG   A 1 160 ? 18.924 1.878   3.459  1    53.55  ?  339 ARG   A NH1   1 
ATOM   1245 N NH2   . ARG   A 1 160 ? 20.061 2.945   5.14   1    52.25  ?  339 ARG   A NH2   1 
ATOM   1246 N N     . GLN   A 1 161 ? 12.015 1.942   2.37   1    51.8   ?  340 GLN   A N     1 
ATOM   1247 C CA    . GLN   A 1 161 ? 10.662 1.481   2.071  1    53.26  ?  340 GLN   A CA    1 
ATOM   1248 C C     . GLN   A 1 161 ? 9.906  1.147   3.344  1    53.22  ?  340 GLN   A C     1 
ATOM   1249 O O     . GLN   A 1 161 ? 10.498 0.675   4.321  1    53.17  ?  340 GLN   A O     1 
ATOM   1250 C CB    . GLN   A 1 161 ? 10.662 0.298   1.086  1    56.58  ?  340 GLN   A CB    1 
ATOM   1251 C CG    . GLN   A 1 161 ? 11.393 0.589   -0.238 1    62.55  ?  340 GLN   A CG    1 
ATOM   1252 C CD    . GLN   A 1 161 ? 10.653 1.549   -1.164 1    69.45  ?  340 GLN   A CD    1 
ATOM   1253 O OE1   . GLN   A 1 161 ? 9.775  1.151   -1.951 1    71.19  ?  340 GLN   A OE1   1 
ATOM   1254 N NE2   . GLN   A 1 161 ? 11.011 2.836   -1.115 1    70.44  ?  340 GLN   A NE2   1 
ATOM   1255 N N     . ASP   A 1 162 ? 8.595  1.423   3.331  1    52.86  ?  341 ASP   A N     1 
ATOM   1256 C CA    . ASP   A 1 162 ? 7.659  1.147   4.419  1    52.59  ?  341 ASP   A CA    1 
ATOM   1257 C C     . ASP   A 1 162 ? 7.793  2.098   5.595  1    50.67  ?  341 ASP   A C     1 
ATOM   1258 O O     . ASP   A 1 162 ? 7.448  1.727   6.712  1    51.04  ?  341 ASP   A O     1 
ATOM   1259 C CB    . ASP   A 1 162 ? 7.733  -0.318  4.874  1    56.15  ?  341 ASP   A CB    1 
ATOM   1260 C CG    . ASP   A 1 162 ? 7.685  -1.288  3.707  1    63.54  ?  341 ASP   A CG    1 
ATOM   1261 O OD1   . ASP   A 1 162 ? 6.809  -1.109  2.818  1    64.81  ?  341 ASP   A OD1   1 
ATOM   1262 O OD2   . ASP   A 1 162 ? 8.55   -2.194  3.654  1    66.42  ?  341 ASP   A OD2   1 
ATOM   1263 N N     . LEU   A 1 163 ? 8.27   3.33    5.354  1    48.71  ?  342 LEU   A N     1 
ATOM   1264 C CA    . LEU   A 1 163 ? 8.328  4.326   6.412  1    46.95  ?  342 LEU   A CA    1 
ATOM   1265 C C     . LEU   A 1 163 ? 6.94   4.966   6.515  1    46.88  ?  342 LEU   A C     1 
ATOM   1266 O O     . LEU   A 1 163 ? 6.366  5.377   5.502  1    46.99  ?  342 LEU   A O     1 
ATOM   1267 C CB    . LEU   A 1 163 ? 9.362  5.405   6.118  1    45.9   ?  342 LEU   A CB    1 
ATOM   1268 C CG    . LEU   A 1 163 ? 10.805 5.089   6.529  1    46.62  ?  342 LEU   A CG    1 
ATOM   1269 C CD1   . LEU   A 1 163 ? 11.746 6.192   6.101  1    46.48  ?  342 LEU   A CD1   1 
ATOM   1270 C CD2   . LEU   A 1 163 ? 10.918 4.849   8.032  1    46.44  ?  342 LEU   A CD2   1 
ATOM   1271 N N     . GLU   A 1 164 ? 6.396  5.024   7.724  1    46.34  ?  343 GLU   A N     1 
ATOM   1272 C CA    . GLU   A 1 164 ? 5.118  5.674   8.012  1    46.8   ?  343 GLU   A CA    1 
ATOM   1273 C C     . GLU   A 1 164 ? 5.272  7.186   7.792  1    46.55  ?  343 GLU   A C     1 
ATOM   1274 O O     . GLU   A 1 164 ? 4.395  7.805   7.21   1    46.93  ?  343 GLU   A O     1 
ATOM   1275 C CB    . GLU   A 1 164 ? 4.698  5.412   9.471  1    49.02  ?  343 GLU   A CB    1 
ATOM   1276 C CG    . GLU   A 1 164 ? 4.189  4.007   9.723  1    54.88  ?  343 GLU   A CG    1 
ATOM   1277 C CD    . GLU   A 1 164 ? 3.962  3.662   11.184 1    63.39  ?  343 GLU   A CD    1 
ATOM   1278 O OE1   . GLU   A 1 164 ? 4.442  4.416   12.064 1    64.39  ?  343 GLU   A OE1   1 
ATOM   1279 O OE2   . GLU   A 1 164 ? 3.319  2.62    11.447 1    66.96  ?  343 GLU   A OE2   1 
ATOM   1280 N N     . GLN   A 1 165 ? 6.398  7.774   8.226  1    45.75  ?  344 GLN   A N     1 
ATOM   1281 C CA    . GLN   A 1 165 ? 6.639  9.204   8.079  1    45.78  ?  344 GLN   A CA    1 
ATOM   1282 C C     . GLN   A 1 165 ? 7.973  9.535   7.385  1    45.98  ?  344 GLN   A C     1 
ATOM   1283 O O     . GLN   A 1 165 ? 8.874  10.081  8.03   1    46.3   ?  344 GLN   A O     1 
ATOM   1284 C CB    . GLN   A 1 165 ? 6.543  9.916   9.453  1    46.86  ?  344 GLN   A CB    1 
ATOM   1285 C CG    . GLN   A 1 165 ? 5.246  9.644   10.202 1    49.79  ?  344 GLN   A CG    1 
ATOM   1286 C CD    . GLN   A 1 165 ? 5.195  10.32   11.545 1    54.28  ?  344 GLN   A CD    1 
ATOM   1287 O OE1   . GLN   A 1 165 ? 5.982  10.033  12.458 1    54.11  ?  344 GLN   A OE1   1 
ATOM   1288 N NE2   . GLN   A 1 165 ? 4.247  11.231  11.696 1    55.33  ?  344 GLN   A NE2   1 
ATOM   1289 N N     . PRO   A 1 166 ? 8.109  9.302   6.056  1    45.75  ?  345 PRO   A N     1 
ATOM   1290 C CA    . PRO   A 1 166 ? 9.4    9.591   5.398  1    45.59  ?  345 PRO   A CA    1 
ATOM   1291 C C     . PRO   A 1 166 ? 9.838  11.049  5.425  1    46.03  ?  345 PRO   A C     1 
ATOM   1292 O O     . PRO   A 1 166 ? 11.039 11.295  5.529  1    45.79  ?  345 PRO   A O     1 
ATOM   1293 C CB    . PRO   A 1 166 ? 9.219  9.072   3.968  1    46.2   ?  345 PRO   A CB    1 
ATOM   1294 C CG    . PRO   A 1 166 ? 7.739  8.912   3.78   1    46.42  ?  345 PRO   A CG    1 
ATOM   1295 C CD    . PRO   A 1 166 ? 7.166  8.633   5.137  1    45.13  ?  345 PRO   A CD    1 
ATOM   1296 N N     . ASP   A 1 167 ? 8.893  12.015  5.321  1    46.5   ?  346 ASP   A N     1 
ATOM   1297 C CA    . ASP   A 1 167 ? 9.228  13.457  5.352  1    47.08  ?  346 ASP   A CA    1 
ATOM   1298 C C     . ASP   A 1 167 ? 9.747  13.88   6.725  1    46.42  ?  346 ASP   A C     1 
ATOM   1299 O O     . ASP   A 1 167 ? 10.626 14.728  6.822  1    45.97  ?  346 ASP   A O     1 
ATOM   1300 C CB    . ASP   A 1 167 ? 8.031  14.335  4.949  1    49.84  ?  346 ASP   A CB    1 
ATOM   1301 C CG    . ASP   A 1 167 ? 7.772  14.4    3.459  1    57.09  ?  346 ASP   A CG    1 
ATOM   1302 O OD1   . ASP   A 1 167 ? 8.76   14.423  2.682  1    58.38  ?  346 ASP   A OD1   1 
ATOM   1303 O OD2   . ASP   A 1 167 ? 6.583  14.445  3.066  1    60.22  ?  346 ASP   A OD2   1 
ATOM   1304 N N     . ARG   A 1 168 ? 9.227  13.265  7.785  1    46.77  ?  347 ARG   A N     1 
ATOM   1305 C CA    . ARG   A 1 168 ? 9.699  13.536  9.138  1    47.54  ?  347 ARG   A CA    1 
ATOM   1306 C C     . ARG   A 1 168 ? 11.16  13.078  9.281  1    47.38  ?  347 ARG   A C     1 
ATOM   1307 O O     . ARG   A 1 168 ? 11.975 13.776  9.89   1    47.28  ?  347 ARG   A O     1 
ATOM   1308 C CB    . ARG   A 1 168 ? 8.822  12.806  10.15  1    49.68  ?  347 ARG   A CB    1 
ATOM   1309 C CG    . ARG   A 1 168 ? 9.108  13.218  11.586 1    53.32  ?  347 ARG   A CG    1 
ATOM   1310 C CD    . ARG   A 1 168 ? 8.027  12.71   12.508 1    57.39  ?  347 ARG   A CD    1 
ATOM   1311 N NE    . ARG   A 1 168 ? 8.295  13.079  13.896 1    61.31  ?  347 ARG   A NE    1 
ATOM   1312 C CZ    . ARG   A 1 168 ? 7.6    12.636  14.937 1    64.32  ?  347 ARG   A CZ    1 
ATOM   1313 N NH1   . ARG   A 1 168 ? 6.59   11.789  14.76  1    63.31  ?  347 ARG   A NH1   1 
ATOM   1314 N NH2   . ARG   A 1 168 ? 7.917  13.025  16.165 1    65.19  ?  347 ARG   A NH2   1 
ATOM   1315 N N     . VAL   A 1 169 ? 11.494 11.921  8.69   1    47.32  ?  348 VAL   A N     1 
ATOM   1316 C CA    . VAL   A 1 169 ? 12.855 11.389  8.713  1    47.66  ?  348 VAL   A CA    1 
ATOM   1317 C C     . VAL   A 1 169 ? 13.776 12.249  7.843  1    47.77  ?  348 VAL   A C     1 
ATOM   1318 O O     . VAL   A 1 169 ? 14.903 12.527  8.245  1    47.35  ?  348 VAL   A O     1 
ATOM   1319 C CB    . VAL   A 1 169 ? 12.886 9.9     8.311  1    48.57  ?  348 VAL   A CB    1 
ATOM   1320 C CG1   . VAL   A 1 169 ? 14.32  9.364   8.322  1    49.34  ?  348 VAL   A CG1   1 
ATOM   1321 C CG2   . VAL   A 1 169 ? 12.004 9.08    9.237  1    48.89  ?  348 VAL   A CG2   1 
ATOM   1322 N N     . ASP   A 1 170 ? 13.27  12.743  6.699  1    48.46  ?  349 ASP   A N     1 
ATOM   1323 C CA    . ASP   A 1 170 ? 14.019 13.637  5.803  1    49.67  ?  349 ASP   A CA    1 
ATOM   1324 C C     . ASP   A 1 170 ? 14.434 14.902  6.559  1    49.77  ?  349 ASP   A C     1 
ATOM   1325 O O     . ASP   A 1 170 ? 15.596 15.297  6.505  1    50.15  ?  349 ASP   A O     1 
ATOM   1326 C CB    . ASP   A 1 170 ? 13.16  14.028  4.582  1    52.76  ?  349 ASP   A CB    1 
ATOM   1327 C CG    . ASP   A 1 170 ? 13.226 13.055  3.433  1    61.2   ?  349 ASP   A CG    1 
ATOM   1328 O OD1   . ASP   A 1 170 ? 14.237 12.321  3.334  1    62.96  ?  349 ASP   A OD1   1 
ATOM   1329 O OD2   . ASP   A 1 170 ? 12.268 13.031  2.618  1    64.78  ?  349 ASP   A OD2   1 
ATOM   1330 N N     . MET   A 1 171 ? 13.48  15.5    7.299  1    49.79  ?  350 MET   A N     1 
ATOM   1331 C CA    . MET   A 1 171 ? 13.679 16.69   8.106  1    50.39  ?  350 MET   A CA    1 
ATOM   1332 C C     . MET   A 1 171 ? 14.731 16.428  9.184  1    49.71  ?  350 MET   A C     1 
ATOM   1333 O O     . MET   A 1 171 ? 15.639 17.231  9.346  1    49.71  ?  350 MET   A O     1 
ATOM   1334 C CB    . MET   A 1 171 ? 12.337 17.115  8.734  1    52.65  ?  350 MET   A CB    1 
ATOM   1335 C CG    . MET   A 1 171 ? 11.991 18.573  8.513  1    57.19  ?  350 MET   A CG    1 
ATOM   1336 S SD    . MET   A 1 171 ? 11.89  19.026  6.764  1    65.64  ?  350 MET   A SD    1 
ATOM   1337 C CE    . MET   A 1 171 ? 10.436 18.078  6.278  1    65.62  ?  350 MET   A CE    1 
ATOM   1338 N N     . LEU   A 1 172 ? 14.638 15.285  9.883  1    48.88  ?  351 LEU   A N     1 
ATOM   1339 C CA    . LEU   A 1 172 ? 15.609 14.902  10.914 1    48.46  ?  351 LEU   A CA    1 
ATOM   1340 C C     . LEU   A 1 172 ? 17.043 14.725  10.36  1    47.21  ?  351 LEU   A C     1 
ATOM   1341 O O     . LEU   A 1 172 ? 18.005 15.034  11.059 1    46.35  ?  351 LEU   A O     1 
ATOM   1342 C CB    . LEU   A 1 172 ? 15.148 13.599  11.569 1    49.31  ?  351 LEU   A CB    1 
ATOM   1343 C CG    . LEU   A 1 172 ? 15.6   13.4    12.998 1    52.35  ?  351 LEU   A CG    1 
ATOM   1344 C CD1   . LEU   A 1 172 ? 14.991 14.475  13.907 1    53.5   ?  351 LEU   A CD1   1 
ATOM   1345 C CD2   . LEU   A 1 172 ? 15.209 12.002  13.498 1    53.38  ?  351 LEU   A CD2   1 
ATOM   1346 N N     . GLN   A 1 173 ? 17.183 14.238  9.102  1    46.61  ?  352 GLN   A N     1 
ATOM   1347 C CA    . GLN   A 1 173 ? 18.492 14.04   8.468  1    47.06  ?  352 GLN   A CA    1 
ATOM   1348 C C     . GLN   A 1 173 ? 19.206 15.346  8.065  1    48.56  ?  352 GLN   A C     1 
ATOM   1349 O O     . GLN   A 1 173 ? 20.431 15.429  8.198  1    48.28  ?  352 GLN   A O     1 
ATOM   1350 C CB    . GLN   A 1 173 ? 18.373 13.126  7.243  1    46.72  ?  352 GLN   A CB    1 
ATOM   1351 C CG    . GLN   A 1 173 ? 19.707 12.816  6.583  1    47.21  ?  352 GLN   A CG    1 
ATOM   1352 C CD    . GLN   A 1 173 ? 19.493 12.089  5.284  1    49.84  ?  352 GLN   A CD    1 
ATOM   1353 O OE1   . GLN   A 1 173 ? 18.666 12.478  4.46   1    50.43  ?  352 GLN   A OE1   1 
ATOM   1354 N NE2   . GLN   A 1 173 ? 20.224 11.004  5.083  1    49.66  ?  352 GLN   A NE2   1 
ATOM   1355 N N     . GLU   A 1 174 ? 18.442 16.346  7.55   1    49.77  ?  353 GLU   A N     1 
ATOM   1356 C CA    . GLU   A 1 174 ? 18.962 17.644  7.09   1    51.22  ?  353 GLU   A CA    1 
ATOM   1357 C C     . GLU   A 1 174 ? 19.904 18.329  8.101  1    51.73  ?  353 GLU   A C     1 
ATOM   1358 O O     . GLU   A 1 174 ? 21.014 18.683  7.698  1    51.95  ?  353 GLU   A O     1 
ATOM   1359 C CB    . GLU   A 1 174 ? 17.829 18.599  6.631  1    54.65  ?  353 GLU   A CB    1 
ATOM   1360 C CG    . GLU   A 1 174 ? 17.141 18.166  5.344  1    61.54  ?  353 GLU   A CG    1 
ATOM   1361 C CD    . GLU   A 1 174 ? 16.091 19.11   4.779  1    71     ?  353 GLU   A CD    1 
ATOM   1362 O OE1   . GLU   A 1 174 ? 15.145 19.467  5.52   1    73.44  ?  353 GLU   A OE1   1 
ATOM   1363 O OE2   . GLU   A 1 174 ? 16.202 19.478  3.585  1    73.66  ?  353 GLU   A OE2   1 
ATOM   1364 N N     . PRO   A 1 175 ? 19.564 18.471  9.407  1    51.67  ?  354 PRO   A N     1 
ATOM   1365 C CA    . PRO   A 1 175 ? 20.531 19.069  10.345 1    51.7   ?  354 PRO   A CA    1 
ATOM   1366 C C     . PRO   A 1 175 ? 21.849 18.299  10.434 1    51.77  ?  354 PRO   A C     1 
ATOM   1367 O O     . PRO   A 1 175 ? 22.876 18.931  10.666 1    52.27  ?  354 PRO   A O     1 
ATOM   1368 C CB    . PRO   A 1 175 ? 19.805 19.043  11.69  1    52.39  ?  354 PRO   A CB    1 
ATOM   1369 C CG    . PRO   A 1 175 ? 18.39  18.836  11.373 1    52.89  ?  354 PRO   A CG    1 
ATOM   1370 C CD    . PRO   A 1 175 ? 18.317 18.099  10.094 1    51.19  ?  354 PRO   A CD    1 
ATOM   1371 N N     . LEU   A 1 176 ? 21.839 16.953  10.238 1    51.12  ?  355 LEU   A N     1 
ATOM   1372 C CA    . LEU   A 1 176 ? 23.065 16.137  10.292 1    51.38  ?  355 LEU   A CA    1 
ATOM   1373 C C     . LEU   A 1 176 ? 23.994 16.373  9.09   1    52.38  ?  355 LEU   A C     1 
ATOM   1374 O O     . LEU   A 1 176 ? 25.217 16.413  9.252  1    52.59  ?  355 LEU   A O     1 
ATOM   1375 C CB    . LEU   A 1 176 ? 22.736 14.643  10.415 1    50.77  ?  355 LEU   A CB    1 
ATOM   1376 C CG    . LEU   A 1 176 ? 21.977 14.246  11.656 1    51.08  ?  355 LEU   A CG    1 
ATOM   1377 C CD1   . LEU   A 1 176 ? 21.156 12.996  11.419 1    51.3   ?  355 LEU   A CD1   1 
ATOM   1378 C CD2   . LEU   A 1 176 ? 22.909 14.098  12.844 1    51.37  ?  355 LEU   A CD2   1 
ATOM   1379 N N     . LEU   A 1 177 ? 23.413 16.51   7.889  1    53.1   ?  356 LEU   A N     1 
ATOM   1380 C CA    . LEU   A 1 177 ? 24.151 16.771  6.647  1    54.25  ?  356 LEU   A CA    1 
ATOM   1381 C C     . LEU   A 1 177 ? 24.801 18.152  6.704  1    56     ?  356 LEU   A C     1 
ATOM   1382 O O     . LEU   A 1 177 ? 25.947 18.321  6.283  1    56.33  ?  356 LEU   A O     1 
ATOM   1383 C CB    . LEU   A 1 177 ? 23.209 16.689  5.436  1    53.8   ?  356 LEU   A CB    1 
ATOM   1384 C CG    . LEU   A 1 177 ? 22.79  15.29   5.041  1    54.84  ?  356 LEU   A CG    1 
ATOM   1385 C CD1   . LEU   A 1 177 ? 21.546 15.309  4.229  1    55.43  ?  356 LEU   A CD1   1 
ATOM   1386 C CD2   . LEU   A 1 177 ? 23.877 14.599  4.286  1    55.41  ?  356 LEU   A CD2   1 
ATOM   1387 N N     . GLU   A 1 178 ? 24.075 19.137  7.25   1    56.82  ?  357 GLU   A N     1 
ATOM   1388 C CA    . GLU   A 1 178 ? 24.583 20.489  7.405  1    58.06  ?  357 GLU   A CA    1 
ATOM   1389 C C     . GLU   A 1 178 ? 25.754 20.463  8.398  1    58.57  ?  357 GLU   A C     1 
ATOM   1390 O O     . GLU   A 1 178 ? 26.836 20.923  8.049  1    59.27  ?  357 GLU   A O     1 
ATOM   1391 C CB    . GLU   A 1 178 ? 23.453 21.418  7.88   1    61.35  ?  357 GLU   A CB    1 
ATOM   1392 C CG    . GLU   A 1 178 ? 23.908 22.828  8.211  1    67.96  ?  357 GLU   A CG    1 
ATOM   1393 C CD    . GLU   A 1 178 ? 22.815 23.701  8.798  1    75.51  ?  357 GLU   A CD    1 
ATOM   1394 O OE1   . GLU   A 1 178 ? 22.254 23.327  9.855  1    76.2   ?  357 GLU   A OE1   1 
ATOM   1395 O OE2   . GLU   A 1 178 ? 22.519 24.762  8.201  1    78.27  ?  357 GLU   A OE2   1 
ATOM   1396 N N     . ALA   A 1 179 ? 25.57  19.829  9.578  1    58.1   ?  358 ALA   A N     1 
ATOM   1397 C CA    . ALA   A 1 179 ? 26.607 19.677  10.604 1    58.13  ?  358 ALA   A CA    1 
ATOM   1398 C C     . ALA   A 1 179 ? 27.854 18.99   10.061 1    58.1   ?  358 ALA   A C     1 
ATOM   1399 O O     . ALA   A 1 179 ? 28.961 19.422  10.379 1    58.32  ?  358 ALA   A O     1 
ATOM   1400 C CB    . ALA   A 1 179 ? 26.069 18.899  11.792 1    58.38  ?  358 ALA   A CB    1 
ATOM   1401 N N     . LEU   A 1 180 ? 27.69  17.95   9.214  1    57.73  ?  359 LEU   A N     1 
ATOM   1402 C CA    . LEU   A 1 180 ? 28.846 17.284  8.617  1    57.91  ?  359 LEU   A CA    1 
ATOM   1403 C C     . LEU   A 1 180 ? 29.59  18.251  7.703  1    59.47  ?  359 LEU   A C     1 
ATOM   1404 O O     . LEU   A 1 180 ? 30.8   18.4    7.844  1    59.16  ?  359 LEU   A O     1 
ATOM   1405 C CB    . LEU   A 1 180 ? 28.442 16.011  7.845  1    57.19  ?  359 LEU   A CB    1 
ATOM   1406 C CG    . LEU   A 1 180 ? 29.596 15.166  7.256  1    57.44  ?  359 LEU   A CG    1 
ATOM   1407 C CD1   . LEU   A 1 180 ? 30.579 14.734  8.328  1    57.5   ?  359 LEU   A CD1   1 
ATOM   1408 C CD2   . LEU   A 1 180 ? 29.073 13.933  6.541  1    57.58  ?  359 LEU   A CD2   1 
ATOM   1409 N N     . LYS   A 1 181 ? 28.855 18.964  6.821  1    60.73  ?  360 LYS   A N     1 
ATOM   1410 C CA    . LYS   A 1 181 ? 29.446 19.92   5.886  1    62.29  ?  360 LYS   A CA    1 
ATOM   1411 C C     . LYS   A 1 181 ? 30.31  20.982  6.578  1    63.68  ?  360 LYS   A C     1 
ATOM   1412 O O     . LYS   A 1 181 ? 31.488 21.112  6.238  1    63.63  ?  360 LYS   A O     1 
ATOM   1413 C CB    . LYS   A 1 181 ? 28.365 20.546  4.99   1    64.8   ?  360 LYS   A CB    1 
ATOM   1414 C CG    . LYS   A 1 181 ? 28.887 21.602  4.019  1    69.6   ?  360 LYS   A CG    1 
ATOM   1415 C CD    . LYS   A 1 181 ? 28.019 21.732  2.766  1    74.36  ?  360 LYS   A CD    1 
ATOM   1416 C CE    . LYS   A 1 181 ? 26.586 22.127  3.051  1    78.25  ?  360 LYS   A CE    1 
ATOM   1417 N NZ    . LYS   A 1 181 ? 25.764 22.133  1.806  1    80.65  ?  360 LYS   A NZ    1 
ATOM   1418 N N     . VAL   A 1 182 ? 29.76  21.697  7.57   1    64.9   ?  361 VAL   A N     1 
ATOM   1419 C CA    . VAL   A 1 182 ? 30.537 22.717  8.274  1    66.77  ?  361 VAL   A CA    1 
ATOM   1420 C C     . VAL   A 1 182 ? 31.711 22.127  9.031  1    68.25  ?  361 VAL   A C     1 
ATOM   1421 O O     . VAL   A 1 182 ? 32.782 22.72   8.995  1    68.8   ?  361 VAL   A O     1 
ATOM   1422 C CB    . VAL   A 1 182 ? 29.701 23.645  9.175  1    67.97  ?  361 VAL   A CB    1 
ATOM   1423 C CG1   . VAL   A 1 182 ? 28.984 24.712  8.355  1    68.89  ?  361 VAL   A CG1   1 
ATOM   1424 C CG2   . VAL   A 1 182 ? 28.715 22.85   10.007 1    68.53  ?  361 VAL   A CG2   1 
ATOM   1425 N N     . TYR   A 1 183 ? 31.54  20.964  9.688  1    68.72  ?  362 TYR   A N     1 
ATOM   1426 C CA    . TYR   A 1 183 ? 32.625 20.337  10.448 1    69.54  ?  362 TYR   A CA    1 
ATOM   1427 C C     . TYR   A 1 183 ? 33.783 19.925  9.559  1    71.5   ?  362 TYR   A C     1 
ATOM   1428 O O     . TYR   A 1 183 ? 34.937 20.112  9.936  1    71.81  ?  362 TYR   A O     1 
ATOM   1429 C CB    . TYR   A 1 183 ? 32.126 19.124  11.244 1    68.82  ?  362 TYR   A CB    1 
ATOM   1430 C CG    . TYR   A 1 183 ? 33.185 18.526  12.142 1    68.44  ?  362 TYR   A CG    1 
ATOM   1431 C CD1   . TYR   A 1 183 ? 33.485 19.096  13.369 1    69.1   ?  362 TYR   A CD1   1 
ATOM   1432 C CD2   . TYR   A 1 183 ? 33.877 17.383  11.77  1    68.74  ?  362 TYR   A CD2   1 
ATOM   1433 C CE1   . TYR   A 1 183 ? 34.45  18.547  14.202 1    69.7   ?  362 TYR   A CE1   1 
ATOM   1434 C CE2   . TYR   A 1 183 ? 34.858 16.836  12.584 1    69.38  ?  362 TYR   A CE2   1 
ATOM   1435 C CZ    . TYR   A 1 183 ? 35.138 17.419  13.804 1    70.15  ?  362 TYR   A CZ    1 
ATOM   1436 O OH    . TYR   A 1 183 ? 36.085 16.875  14.632 1    71.04  ?  362 TYR   A OH    1 
ATOM   1437 N N     . VAL   A 1 184 ? 33.488 19.371  8.383  1    72.79  ?  363 VAL   A N     1 
ATOM   1438 C CA    . VAL   A 1 184 ? 34.529 18.953  7.451  1    74.81  ?  363 VAL   A CA    1 
ATOM   1439 C C     . VAL   A 1 184 ? 35.336 20.166  6.979  1    77.29  ?  363 VAL   A C     1 
ATOM   1440 O O     . VAL   A 1 184 ? 36.564 20.106  6.93   1    77.91  ?  363 VAL   A O     1 
ATOM   1441 C CB    . VAL   A 1 184 ? 33.926 18.152  6.276  1    75.38  ?  363 VAL   A CB    1 
ATOM   1442 C CG1   . VAL   A 1 184 ? 34.936 17.959  5.153  1    75.88  ?  363 VAL   A CG1   1 
ATOM   1443 C CG2   . VAL   A 1 184 ? 33.399 16.808  6.756  1    75.89  ?  363 VAL   A CG2   1 
ATOM   1444 N N     . ARG   A 1 185 ? 34.651 21.284  6.699  1    78.51  ?  364 ARG   A N     1 
ATOM   1445 C CA    . ARG   A 1 185 ? 35.304 22.51   6.252  1    79.97  ?  364 ARG   A CA    1 
ATOM   1446 C C     . ARG   A 1 185 ? 36.057 23.195  7.39   1    81.24  ?  364 ARG   A C     1 
ATOM   1447 O O     . ARG   A 1 185 ? 37.118 23.758  7.16   1    81.65  ?  364 ARG   A O     1 
ATOM   1448 C CB    . ARG   A 1 185 ? 34.285 23.47   5.62   1    81.47  ?  364 ARG   A CB    1 
ATOM   1449 N N     . LYS   A 1 186 ? 35.523 23.149  8.612  1    81.78  ?  365 LYS   A N     1 
ATOM   1450 C CA    . LYS   A 1 186 ? 36.171 23.768  9.765  1    82.71  ?  365 LYS   A CA    1 
ATOM   1451 C C     . LYS   A 1 186 ? 37.412 22.99   10.2   1    83.57  ?  365 LYS   A C     1 
ATOM   1452 O O     . LYS   A 1 186 ? 38.409 23.596  10.586 1    83.8   ?  365 LYS   A O     1 
ATOM   1453 C CB    . LYS   A 1 186 ? 35.189 23.919  10.936 1    84.37  ?  365 LYS   A CB    1 
ATOM   1454 N N     . ARG   A 1 187 ? 37.365 21.655  10.123 1    83.9   ?  366 ARG   A N     1 
ATOM   1455 C CA    . ARG   A 1 187 ? 38.497 20.824  10.525 1    84.59  ?  366 ARG   A CA    1 
ATOM   1456 C C     . ARG   A 1 187 ? 39.56  20.766  9.428  1    85.55  ?  366 ARG   A C     1 
ATOM   1457 O O     . ARG   A 1 187 ? 40.753 20.851  9.722  1    85.66  ?  366 ARG   A O     1 
ATOM   1458 C CB    . ARG   A 1 187 ? 38.029 19.415  10.923 1    85.16  ?  366 ARG   A CB    1 
ATOM   1459 C CG    . ARG   A 1 187 ? 39.137 18.555  11.505 1    86.41  ?  366 ARG   A CG    1 
ATOM   1460 C CD    . ARG   A 1 187 ? 38.653 17.186  11.916 1    87.63  ?  366 ARG   A CD    1 
ATOM   1461 N NE    . ARG   A 1 187 ? 39.783 16.315  12.236 1    88.71  ?  366 ARG   A NE    1 
ATOM   1462 C CZ    . ARG   A 1 187 ? 40.107 15.223  11.556 1    89.36  ?  366 ARG   A CZ    1 
ATOM   1463 N NH1   . ARG   A 1 187 ? 39.364 14.826  10.53  1    88.49  ?  366 ARG   A NH1   1 
ATOM   1464 N NH2   . ARG   A 1 187 ? 41.158 14.499  11.914 1    88.84  ?  366 ARG   A NH2   1 
ATOM   1465 N N     . ARG   A 1 188 ? 39.132 20.626  8.166  1    86.12  ?  367 ARG   A N     1 
ATOM   1466 C CA    . ARG   A 1 188 ? 40.048 20.594  7.024  1    87.32  ?  367 ARG   A CA    1 
ATOM   1467 C C     . ARG   A 1 188 ? 39.66  21.691  6.026  1    88.31  ?  367 ARG   A C     1 
ATOM   1468 O O     . ARG   A 1 188 ? 38.923 21.433  5.072  1    88.48  ?  367 ARG   A O     1 
ATOM   1469 C CB    . ARG   A 1 188 ? 40.02  19.22   6.342  1    88.8   ?  367 ARG   A CB    1 
ATOM   1470 C CG    . ARG   A 1 188 ? 40.447 18.069  7.246  1    92.04  ?  367 ARG   A CG    1 
ATOM   1471 C CD    . ARG   A 1 188 ? 40.631 16.798  6.441  1    95.16  ?  367 ARG   A CD    1 
ATOM   1472 N NE    . ARG   A 1 188 ? 40.299 15.593  7.201  1    97.55  ?  367 ARG   A NE    1 
ATOM   1473 C CZ    . ARG   A 1 188 ? 39.081 15.064  7.279  1    99.54  ?  367 ARG   A CZ    1 
ATOM   1474 N NH1   . ARG   A 1 188 ? 38.055 15.647  6.67   1    99.16  ?  367 ARG   A NH1   1 
ATOM   1475 N NH2   . ARG   A 1 188 ? 38.872 13.968  7.994  1    99.42  ?  367 ARG   A NH2   1 
ATOM   1476 N N     . PRO   A 1 189 ? 40.118 22.935  6.25   1    88.76  ?  368 PRO   A N     1 
ATOM   1477 C CA    . PRO   A 1 189 ? 39.711 24.037  5.36   1    89.24  ?  368 PRO   A CA    1 
ATOM   1478 C C     . PRO   A 1 189 ? 40.384 24.076  3.998  1    90.08  ?  368 PRO   A C     1 
ATOM   1479 O O     . PRO   A 1 189 ? 39.826 24.635  3.057  1    89.92  ?  368 PRO   A O     1 
ATOM   1480 C CB    . PRO   A 1 189 ? 40.033 25.286  6.18   1    89.84  ?  368 PRO   A CB    1 
ATOM   1481 C CG    . PRO   A 1 189 ? 41.154 24.873  7.068  1    90.18  ?  368 PRO   A CG    1 
ATOM   1482 C CD    . PRO   A 1 189 ? 40.97  23.408  7.36   1    88.42  ?  368 PRO   A CD    1 
ATOM   1483 N N     . SER   A 1 190 ? 41.585 23.502  3.899  1    90.8   ?  369 SER   A N     1 
ATOM   1484 C CA    . SER   A 1 190 ? 42.356 23.488  2.662  1    91.86  ?  369 SER   A CA    1 
ATOM   1485 C C     . SER   A 1 190 ? 41.728 22.595  1.585  1    92.76  ?  369 SER   A C     1 
ATOM   1486 O O     . SER   A 1 190 ? 41.845 22.894  0.397  1    92.96  ?  369 SER   A O     1 
ATOM   1487 C CB    . SER   A 1 190 ? 43.796 23.066  2.94   1    93.06  ?  369 SER   A CB    1 
ATOM   1488 O OG    . SER   A 1 190 ? 43.852 21.833  3.641  1    95.2   ?  369 SER   A OG    1 
ATOM   1489 N N     . ARG   A 1 191 ? 41.058 21.511  1.996  1    93.02  ?  370 ARG   A N     1 
ATOM   1490 C CA    . ARG   A 1 191 ? 40.43  20.587  1.055  1    93.69  ?  370 ARG   A CA    1 
ATOM   1491 C C     . ARG   A 1 191 ? 38.907 20.694  1.106  1    94.1   ?  370 ARG   A C     1 
ATOM   1492 O O     . ARG   A 1 191 ? 38.269 20.023  1.916  1    94.3   ?  370 ARG   A O     1 
ATOM   1493 C CB    . ARG   A 1 191 ? 40.871 19.148  1.361  1    95.01  ?  370 ARG   A CB    1 
ATOM   1494 N N     . PRO   A 1 192 ? 38.295 21.518  0.239  1    94.04  ?  371 PRO   A N     1 
ATOM   1495 C CA    . PRO   A 1 192 ? 36.824 21.65   0.269  1    94.02  ?  371 PRO   A CA    1 
ATOM   1496 C C     . PRO   A 1 192 ? 36.04  20.573  -0.502 1    93.94  ?  371 PRO   A C     1 
ATOM   1497 O O     . PRO   A 1 192 ? 34.811 20.619  -0.545 1    94.13  ?  371 PRO   A O     1 
ATOM   1498 C CB    . PRO   A 1 192 ? 36.587 23.05   -0.301 1    94.76  ?  371 PRO   A CB    1 
ATOM   1499 C CG    . PRO   A 1 192 ? 37.77  23.303  -1.194 1    95.2   ?  371 PRO   A CG    1 
ATOM   1500 C CD    . PRO   A 1 192 ? 38.906 22.396  -0.779 1    93.58  ?  371 PRO   A CD    1 
ATOM   1501 N N     . HIS   A 1 193 ? 36.748 19.614  -1.115 1    93.47  ?  372 HIS   A N     1 
ATOM   1502 C CA    . HIS   A 1 193 ? 36.151 18.514  -1.886 1    93.44  ?  372 HIS   A CA    1 
ATOM   1503 C C     . HIS   A 1 193 ? 35.822 17.262  -1.04  1    92.37  ?  372 HIS   A C     1 
ATOM   1504 O O     . HIS   A 1 193 ? 35.24  16.31   -1.562 1    92.52  ?  372 HIS   A O     1 
ATOM   1505 C CB    . HIS   A 1 193 ? 37.084 18.114  -3.049 1    94.97  ?  372 HIS   A CB    1 
ATOM   1506 C CG    . HIS   A 1 193 ? 38.536 18.002  -2.668 1    98.34  ?  372 HIS   A CG    1 
ATOM   1507 N ND1   . HIS   A 1 193 ? 39.518 18.704  -3.353 1    100.48 ?  372 HIS   A ND1   1 
ATOM   1508 C CD2   . HIS   A 1 193 ? 39.121 17.296  -1.67  1    99.67  ?  372 HIS   A CD2   1 
ATOM   1509 C CE1   . HIS   A 1 193 ? 40.661 18.392  -2.762 1    101.07 ?  372 HIS   A CE1   1 
ATOM   1510 N NE2   . HIS   A 1 193 ? 40.473 17.549  -1.744 1    100.95 ?  372 HIS   A NE2   1 
ATOM   1511 N N     . MET   A 1 194 ? 36.228 17.254  0.241  1    91.03  ?  373 MET   A N     1 
ATOM   1512 C CA    . MET   A 1 194 ? 36.063 16.136  1.162  1    90.19  ?  373 MET   A CA    1 
ATOM   1513 C C     . MET   A 1 194 ? 34.603 15.783  1.475  1    88.52  ?  373 MET   A C     1 
ATOM   1514 O O     . MET   A 1 194 ? 34.267 14.599  1.539  1    88.81  ?  373 MET   A O     1 
ATOM   1515 C CB    . MET   A 1 194 ? 36.856 16.407  2.45   1    91.37  ?  373 MET   A CB    1 
ATOM   1516 C CG    . MET   A 1 194 ? 36.848 15.258  3.426  1    94.78  ?  373 MET   A CG    1 
ATOM   1517 S SD    . MET   A 1 194 ? 38.025 13.953  3.002  1    102.54 ?  373 MET   A SD    1 
ATOM   1518 C CE    . MET   A 1 194 ? 39.546 14.699  3.561  1    101.03 ?  373 MET   A CE    1 
ATOM   1519 N N     . PHE   A 1 195 ? 33.735 16.795  1.642  1    86.51  ?  374 PHE   A N     1 
ATOM   1520 C CA    . PHE   A 1 195 ? 32.327 16.573  1.977  1    84.84  ?  374 PHE   A CA    1 
ATOM   1521 C C     . PHE   A 1 195 ? 31.569 15.675  0.97   1    82.97  ?  374 PHE   A C     1 
ATOM   1522 O O     . PHE   A 1 195 ? 31.072 14.642  1.413  1    82.85  ?  374 PHE   A O     1 
ATOM   1523 C CB    . PHE   A 1 195 ? 31.584 17.891  2.228  1    84.55  ?  374 PHE   A CB    1 
ATOM   1524 C CG    . PHE   A 1 195 ? 30.143 17.7    2.621  1    84.67  ?  374 PHE   A CG    1 
ATOM   1525 C CD1   . PHE   A 1 195 ? 29.805 16.935  3.721  1    85.23  ?  374 PHE   A CD1   1 
ATOM   1526 C CD2   . PHE   A 1 195 ? 29.128 18.289  1.894  1    85.23  ?  374 PHE   A CD2   1 
ATOM   1527 C CE1   . PHE   A 1 195 ? 28.478 16.759  4.08   1    85.9   ?  374 PHE   A CE1   1 
ATOM   1528 C CE2   . PHE   A 1 195 ? 27.803 18.122  2.264  1    85.85  ?  374 PHE   A CE2   1 
ATOM   1529 C CZ    . PHE   A 1 195 ? 27.486 17.368  3.36   1    85.66  ?  374 PHE   A CZ    1 
ATOM   1530 N N     . PRO   A 1 196 ? 31.476 15.98   -0.35  1    81.42  ?  375 PRO   A N     1 
ATOM   1531 C CA    . PRO   A 1 196 ? 30.775 15.051  -1.257 1    80.17  ?  375 PRO   A CA    1 
ATOM   1532 C C     . PRO   A 1 196 ? 31.505 13.71   -1.428 1    78.41  ?  375 PRO   A C     1 
ATOM   1533 O O     . PRO   A 1 196 ? 30.865 12.714  -1.763 1    78.22  ?  375 PRO   A O     1 
ATOM   1534 C CB    . PRO   A 1 196 ? 30.696 15.832  -2.567 1    81.1   ?  375 PRO   A CB    1 
ATOM   1535 C CG    . PRO   A 1 196 ? 31.872 16.731  -2.523 1    81.88  ?  375 PRO   A CG    1 
ATOM   1536 C CD    . PRO   A 1 196 ? 31.996 17.149  -1.088 1    80.69  ?  375 PRO   A CD    1 
ATOM   1537 N N     . LYS   A 1 197 ? 32.832 13.673  -1.169 1    76.9   ?  376 LYS   A N     1 
ATOM   1538 C CA    . LYS   A 1 197 ? 33.619 12.441  -1.24  1    76.01  ?  376 LYS   A CA    1 
ATOM   1539 C C     . LYS   A 1 197 ? 33.169 11.483  -0.119 1    74.6   ?  376 LYS   A C     1 
ATOM   1540 O O     . LYS   A 1 197 ? 32.964 10.295  -0.37  1    74.6   ?  376 LYS   A O     1 
ATOM   1541 C CB    . LYS   A 1 197 ? 35.12  12.746  -1.123 1    77.6   ?  376 LYS   A CB    1 
ATOM   1542 N N     . MET   A 1 198 ? 32.959 12.026  1.098  1    73     ?  377 MET   A N     1 
ATOM   1543 C CA    . MET   A 1 198 ? 32.471 11.283  2.26   1    71.8   ?  377 MET   A CA    1 
ATOM   1544 C C     . MET   A 1 198 ? 31.081 10.715  1.994  1    70.23  ?  377 MET   A C     1 
ATOM   1545 O O     . MET   A 1 198 ? 30.786 9.594   2.391  1    69.88  ?  377 MET   A O     1 
ATOM   1546 C CB    . MET   A 1 198 ? 32.402 12.201  3.485  1    72.41  ?  377 MET   A CB    1 
ATOM   1547 C CG    . MET   A 1 198 ? 33.717 12.4    4.15   1    74.82  ?  377 MET   A CG    1 
ATOM   1548 S SD    . MET   A 1 198 ? 33.506 13.349  5.664  1    79.52  ?  377 MET   A SD    1 
ATOM   1549 C CE    . MET   A 1 198 ? 35.159 13.376  6.235  1    77.98  ?  377 MET   A CE    1 
ATOM   1550 N N     . LEU   A 1 199 ? 30.224 11.492  1.332  1    69.32  ?  378 LEU   A N     1 
ATOM   1551 C CA    . LEU   A 1 199 ? 28.877 11.045  0.999  1    68.99  ?  378 LEU   A CA    1 
ATOM   1552 C C     . LEU   A 1 199 ? 28.874 9.935   -0.037 1    68.27  ?  378 LEU   A C     1 
ATOM   1553 O O     . LEU   A 1 199 ? 27.963 9.108   -0.026 1    68.53  ?  378 LEU   A O     1 
ATOM   1554 C CB    . LEU   A 1 199 ? 28.011 12.213  0.564  1    69.44  ?  378 LEU   A CB    1 
ATOM   1555 C CG    . LEU   A 1 199 ? 27.709 13.174  1.686  1    71.37  ?  378 LEU   A CG    1 
ATOM   1556 C CD1   . LEU   A 1 199 ? 27.65  14.585  1.185  1    72.19  ?  378 LEU   A CD1   1 
ATOM   1557 C CD2   . LEU   A 1 199 ? 26.454 12.769  2.414  1    72.16  ?  378 LEU   A CD2   1 
ATOM   1558 N N     . MET   A 1 200 ? 29.903 9.875   -0.897 1    67.32  ?  379 MET   A N     1 
ATOM   1559 C CA    . MET   A 1 200 ? 30.016 8.792   -1.866 1    67.23  ?  379 MET   A CA    1 
ATOM   1560 C C     . MET   A 1 200 ? 30.168 7.441   -1.165 1    65.44  ?  379 MET   A C     1 
ATOM   1561 O O     . MET   A 1 200 ? 29.64  6.444   -1.654 1    65.19  ?  379 MET   A O     1 
ATOM   1562 C CB    . MET   A 1 200 ? 31.18  9.032   -2.843 1    69.18  ?  379 MET   A CB    1 
ATOM   1563 C CG    . MET   A 1 200 ? 30.863 10.06   -3.936 1    73.41  ?  379 MET   A CG    1 
ATOM   1564 S SD    . MET   A 1 200 ? 29.394 9.672   -4.935 1    81.05  ?  379 MET   A SD    1 
ATOM   1565 C CE    . MET   A 1 200 ? 28.238 10.948  -4.321 1    77.04  ?  379 MET   A CE    1 
ATOM   1566 N N     . LYS   A 1 201 ? 30.835 7.419   0.009  1    63.98  ?  380 LYS   A N     1 
ATOM   1567 C CA    . LYS   A 1 201 ? 31.02  6.21    0.8    1    63.09  ?  380 LYS   A CA    1 
ATOM   1568 C C     . LYS   A 1 201 ? 29.677 5.602   1.189  1    61.73  ?  380 LYS   A C     1 
ATOM   1569 O O     . LYS   A 1 201 ? 29.544 4.388   1.16   1    61.59  ?  380 LYS   A O     1 
ATOM   1570 C CB    . LYS   A 1 201 ? 31.877 6.495   2.041  1    65.13  ?  380 LYS   A CB    1 
ATOM   1571 C CG    . LYS   A 1 201 ? 33.184 7.212   1.727  1    69.69  ?  380 LYS   A CG    1 
ATOM   1572 C CD    . LYS   A 1 201 ? 34.122 6.356   0.878  1    75.17  ?  380 LYS   A CD    1 
ATOM   1573 C CE    . LYS   A 1 201 ? 35.215 7.183   0.242  1    79.7   ?  380 LYS   A CE    1 
ATOM   1574 N NZ    . LYS   A 1 201 ? 36.3   6.336   -0.32  1    82.39  ?  380 LYS   A NZ    1 
ATOM   1575 N N     . ILE   A 1 202 ? 28.663 6.438   1.465  1    60.61  ?  381 ILE   A N     1 
ATOM   1576 C CA    . ILE   A 1 202 ? 27.317 5.986   1.812  1    60.33  ?  381 ILE   A CA    1 
ATOM   1577 C C     . ILE   A 1 202 ? 26.679 5.218   0.654  1    59.46  ?  381 ILE   A C     1 
ATOM   1578 O O     . ILE   A 1 202 ? 26.04  4.184   0.873  1    59.06  ?  381 ILE   A O     1 
ATOM   1579 C CB    . ILE   A 1 202 ? 26.468 7.197   2.273  1    61.36  ?  381 ILE   A CB    1 
ATOM   1580 C CG1   . ILE   A 1 202 ? 27.025 7.769   3.591  1    62.53  ?  381 ILE   A CG1   1 
ATOM   1581 C CG2   . ILE   A 1 202 ? 24.992 6.843   2.388  1    61.86  ?  381 ILE   A CG2   1 
ATOM   1582 C CD1   . ILE   A 1 202 ? 26.45  9.047   4.013  1    64.02  ?  381 ILE   A CD1   1 
ATOM   1583 N N     . THR   A 1 203 ? 26.912 5.683   -0.586 1    58.88  ?  382 THR   A N     1 
ATOM   1584 C CA    . THR   A 1 203 ? 26.41  5.022   -1.795 1    58.93  ?  382 THR   A CA    1 
ATOM   1585 C C     . THR   A 1 203 ? 27.097 3.655   -1.948 1    58.09  ?  382 THR   A C     1 
ATOM   1586 O O     . THR   A 1 203 ? 26.44  2.652   -2.254 1    58.31  ?  382 THR   A O     1 
ATOM   1587 C CB    . THR   A 1 203 ? 26.689 5.881   -3.055 1    60.94  ?  382 THR   A CB    1 
ATOM   1588 O OG1   . THR   A 1 203 ? 26.544 7.282   -2.776 1    62.11  ?  382 THR   A OG1   1 
ATOM   1589 C CG2   . THR   A 1 203 ? 25.835 5.458   -4.242 1    61.13  ?  382 THR   A CG2   1 
ATOM   1590 N N     . ASP   A 1 204 ? 28.421 3.62    -1.71  1    56.93  ?  383 ASP   A N     1 
ATOM   1591 C CA    . ASP   A 1 204 ? 29.209 2.395   -1.765 1    56.49  ?  383 ASP   A CA    1 
ATOM   1592 C C     . ASP   A 1 204 ? 28.714 1.418   -0.701 1    55.3   ?  383 ASP   A C     1 
ATOM   1593 O O     . ASP   A 1 204 ? 28.517 0.247   -0.995 1    55.28  ?  383 ASP   A O     1 
ATOM   1594 C CB    . ASP   A 1 204 ? 30.706 2.707   -1.564 1    58.54  ?  383 ASP   A CB    1 
ATOM   1595 C CG    . ASP   A 1 204 ? 31.229 3.767   -2.512 1    64.59  ?  383 ASP   A CG    1 
ATOM   1596 O OD1   . ASP   A 1 204 ? 30.754 3.819   -3.672 1    65.81  ?  383 ASP   A OD1   1 
ATOM   1597 O OD2   . ASP   A 1 204 ? 32.098 4.556   -2.094 1    67.8   ?  383 ASP   A OD2   1 
ATOM   1598 N N     . LEU   A 1 205 ? 28.449 1.922   0.511  1    53.98  ?  384 LEU   A N     1 
ATOM   1599 C CA    . LEU   A 1 205 ? 27.948 1.169   1.654  1    53.02  ?  384 LEU   A CA    1 
ATOM   1600 C C     . LEU   A 1 205 ? 26.595 0.551   1.339  1    52.66  ?  384 LEU   A C     1 
ATOM   1601 O O     . LEU   A 1 205 ? 26.391 -0.625  1.614  1    52.12  ?  384 LEU   A O     1 
ATOM   1602 C CB    . LEU   A 1 205 ? 27.826 2.135   2.842  1    52.64  ?  384 LEU   A CB    1 
ATOM   1603 C CG    . LEU   A 1 205 ? 28.253 1.697   4.239  1    53.2   ?  384 LEU   A CG    1 
ATOM   1604 C CD1   . LEU   A 1 205 ? 29.484 0.782   4.223  1    53.53  ?  384 LEU   A CD1   1 
ATOM   1605 C CD2   . LEU   A 1 205 ? 28.515 2.914   5.095  1    53.23  ?  384 LEU   A CD2   1 
ATOM   1606 N N     . ARG   A 1 206 ? 25.678 1.321   0.732  1    52.82  ?  385 ARG   A N     1 
ATOM   1607 C CA    . ARG   A 1 206 ? 24.364 0.803   0.359  1    53.93  ?  385 ARG   A CA    1 
ATOM   1608 C C     . ARG   A 1 206 ? 24.514 -0.32   -0.675 1    53.88  ?  385 ARG   A C     1 
ATOM   1609 O O     . ARG   A 1 206 ? 23.844 -1.344  -0.585 1    53.55  ?  385 ARG   A O     1 
ATOM   1610 C CB    . ARG   A 1 206 ? 23.487 1.931   -0.197 1    57.12  ?  385 ARG   A CB    1 
ATOM   1611 C CG    . ARG   A 1 206 ? 22.056 1.896   0.308  1    63.23  ?  385 ARG   A CG    1 
ATOM   1612 C CD    . ARG   A 1 206 ? 21.826 2.893   1.432  1    68.4   ?  385 ARG   A CD    1 
ATOM   1613 N NE    . ARG   A 1 206 ? 21.73  4.26    0.921  1    72.92  ?  385 ARG   A NE    1 
ATOM   1614 C CZ    . ARG   A 1 206 ? 20.595 4.849   0.554  1    75.77  ?  385 ARG   A CZ    1 
ATOM   1615 N NH1   . ARG   A 1 206 ? 19.44  4.2     0.65   1    75.29  ?  385 ARG   A NH1   1 
ATOM   1616 N NH2   . ARG   A 1 206 ? 20.606 6.093   0.092  1    75.8   ?  385 ARG   A NH2   1 
ATOM   1617 N N     . SER   A 1 207 ? 25.436 -0.145  -1.62  1    54.25  ?  386 SER   A N     1 
ATOM   1618 C CA    . SER   A 1 207 ? 25.733 -1.14   -2.641 1    55.39  ?  386 SER   A CA    1 
ATOM   1619 C C     . SER   A 1 207 ? 26.288 -2.431  -1.984 1    55.47  ?  386 SER   A C     1 
ATOM   1620 O O     . SER   A 1 207 ? 25.786 -3.526  -2.259 1    55.53  ?  386 SER   A O     1 
ATOM   1621 C CB    . SER   A 1 207 ? 26.7   -0.544  -3.666 1    57.61  ?  386 SER   A CB    1 
ATOM   1622 O OG    . SER   A 1 207 ? 27.35  -1.51   -4.474 1    61.14  ?  386 SER   A OG    1 
ATOM   1623 N N     . ILE   A 1 208 ? 27.263 -2.293  -1.062 1    55.21  ?  387 ILE   A N     1 
ATOM   1624 C CA    . ILE   A 1 208 ? 27.822 -3.448  -0.351 1    55.61  ?  387 ILE   A CA    1 
ATOM   1625 C C     . ILE   A 1 208 ? 26.746 -4.124  0.507  1    55.66  ?  387 ILE   A C     1 
ATOM   1626 O O     . ILE   A 1 208 ? 26.661 -5.342  0.501  1    55.76  ?  387 ILE   A O     1 
ATOM   1627 C CB    . ILE   A 1 208 ? 29.095 -3.092  0.48   1    56.31  ?  387 ILE   A CB    1 
ATOM   1628 C CG1   . ILE   A 1 208 ? 30.141 -2.347  -0.359 1    57.19  ?  387 ILE   A CG1   1 
ATOM   1629 C CG2   . ILE   A 1 208 ? 29.732 -4.336  1.079  1    56.91  ?  387 ILE   A CG2   1 
ATOM   1630 C CD1   . ILE   A 1 208 ? 31.072 -1.489  0.446  1    58.25  ?  387 ILE   A CD1   1 
ATOM   1631 N N     . SER   A 1 209 ? 25.896 -3.348  1.206  1    55.58  ?  388 SER   A N     1 
ATOM   1632 C CA    . SER   A 1 209 ? 24.847 -3.926  2.048  1    56.42  ?  388 SER   A CA    1 
ATOM   1633 C C     . SER   A 1 209 ? 23.717 -4.56   1.256  1    56.45  ?  388 SER   A C     1 
ATOM   1634 O O     . SER   A 1 209 ? 23.129 -5.534  1.731  1    56.29  ?  388 SER   A O     1 
ATOM   1635 C CB    . SER   A 1 209 ? 24.313 -2.929  3.074  1    58.68  ?  388 SER   A CB    1 
ATOM   1636 O OG    . SER   A 1 209 ? 23.988 -1.682  2.49   1    61.52  ?  388 SER   A OG    1 
ATOM   1637 N N     . ALA   A 1 210 ? 23.467 -4.101  0.015  1    56.61  ?  389 ALA   A N     1 
ATOM   1638 C CA    . ALA   A 1 210 ? 22.472 -4.754  -0.844 1    57.47  ?  389 ALA   A CA    1 
ATOM   1639 C C     . ALA   A 1 210 ? 23     -6.167  -1.175 1    58.37  ?  389 ALA   A C     1 
ATOM   1640 O O     . ALA   A 1 210 ? 22.283 -7.146  -0.966 1    58.55  ?  389 ALA   A O     1 
ATOM   1641 C CB    . ALA   A 1 210 ? 22.246 -3.949  -2.121 1    57.35  ?  389 ALA   A CB    1 
ATOM   1642 N N     . LYS   A 1 211 ? 24.302 -6.271  -1.543 1    58.63  ?  390 LYS   A N     1 
ATOM   1643 C CA    . LYS   A 1 211 ? 24.945 -7.565  -1.796 1    59.49  ?  390 LYS   A CA    1 
ATOM   1644 C C     . LYS   A 1 211 ? 24.977 -8.406  -0.508 1    60.14  ?  390 LYS   A C     1 
ATOM   1645 O O     . LYS   A 1 211 ? 24.738 -9.61   -0.554 1    60.6   ?  390 LYS   A O     1 
ATOM   1646 C CB    . LYS   A 1 211 ? 26.368 -7.372  -2.352 1    61.25  ?  390 LYS   A CB    1 
ATOM   1647 C CG    . LYS   A 1 211 ? 26.565 -7.915  -3.763 1    64.51  ?  390 LYS   A CG    1 
ATOM   1648 C CD    . LYS   A 1 211 ? 26.078 -6.93   -4.81  1    69     ?  390 LYS   A CD    1 
ATOM   1649 C CE    . LYS   A 1 211 ? 26.453 -7.348  -6.214 1    73     ?  390 LYS   A CE    1 
ATOM   1650 N NZ    . LYS   A 1 211 ? 27.804 -6.855  -6.605 1    75.74  ?  390 LYS   A NZ    1 
ATOM   1651 N N     . GLY   A 1 212 ? 25.207 -7.746  0.629  1    60.15  ?  391 GLY   A N     1 
ATOM   1652 C CA    . GLY   A 1 212 ? 25.218 -8.352  1.954  1    60.49  ?  391 GLY   A CA    1 
ATOM   1653 C C     . GLY   A 1 212 ? 23.9   -9.005  2.317  1    60.68  ?  391 GLY   A C     1 
ATOM   1654 O O     . GLY   A 1 212 ? 23.894 -10.059 2.949  1    60.32  ?  391 GLY   A O     1 
ATOM   1655 N N     . ALA   A 1 213 ? 22.771 -8.415  1.899  1    61.44  ?  392 ALA   A N     1 
ATOM   1656 C CA    . ALA   A 1 213 ? 21.45  -9.021  2.155  1    62.64  ?  392 ALA   A CA    1 
ATOM   1657 C C     . ALA   A 1 213 ? 21.316 -10.357 1.395  1    63.64  ?  392 ALA   A C     1 
ATOM   1658 O O     . ALA   A 1 213 ? 20.689 -11.294 1.896  1    64.11  ?  392 ALA   A O     1 
ATOM   1659 C CB    . ALA   A 1 213 ? 20.329 -8.067  1.748  1    62.68  ?  392 ALA   A CB    1 
ATOM   1660 N N     . GLU   A 1 214 ? 21.928 -10.449 0.202  1    63.83  ?  393 GLU   A N     1 
ATOM   1661 C CA    . GLU   A 1 214 ? 21.954 -11.688 -0.572 1    64.59  ?  393 GLU   A CA    1 
ATOM   1662 C C     . GLU   A 1 214 ? 22.896 -12.714 0.104  1    64.46  ?  393 GLU   A C     1 
ATOM   1663 O O     . GLU   A 1 214 ? 22.647 -13.915 0.035  1    64.86  ?  393 GLU   A O     1 
ATOM   1664 C CB    . GLU   A 1 214 ? 22.409 -11.414 -2.012 1    67.57  ?  393 GLU   A CB    1 
ATOM   1665 C CG    . GLU   A 1 214 ? 21.438 -10.551 -2.8   1    73.63  ?  393 GLU   A CG    1 
ATOM   1666 C CD    . GLU   A 1 214 ? 22.006 -9.937  -4.066 1    81.73  ?  393 GLU   A CD    1 
ATOM   1667 O OE1   . GLU   A 1 214 ? 23.102 -10.364 -4.501 1    82.92  ?  393 GLU   A OE1   1 
ATOM   1668 O OE2   . GLU   A 1 214 ? 21.351 -9.028  -4.626 1    84.52  ?  393 GLU   A OE2   1 
ATOM   1669 N N     . ARG   A 1 215 ? 23.969 -12.243 0.762  1    63.47  ?  394 ARG   A N     1 
ATOM   1670 C CA    . ARG   A 1 215 ? 24.894 -13.131 1.451  1    63.12  ?  394 ARG   A CA    1 
ATOM   1671 C C     . ARG   A 1 215 ? 24.266 -13.764 2.679  1    62.62  ?  394 ARG   A C     1 
ATOM   1672 O O     . ARG   A 1 215 ? 24.565 -14.913 2.986  1    62.96  ?  394 ARG   A O     1 
ATOM   1673 C CB    . ARG   A 1 215 ? 26.208 -12.423 1.787  1    64.26  ?  394 ARG   A CB    1 
ATOM   1674 C CG    . ARG   A 1 215 ? 27.281 -13.347 2.345  1    67.14  ?  394 ARG   A CG    1 
ATOM   1675 C CD    . ARG   A 1 215 ? 27.66  -14.434 1.362  1    70.6   ?  394 ARG   A CD    1 
ATOM   1676 N NE    . ARG   A 1 215 ? 28.831 -15.182 1.811  1    74.15  ?  394 ARG   A NE    1 
ATOM   1677 C CZ    . ARG   A 1 215 ? 28.848 -16.49  2.036  1    76.51  ?  394 ARG   A CZ    1 
ATOM   1678 N NH1   . ARG   A 1 215 ? 27.753 -17.218 1.847  1    76.45  ?  394 ARG   A NH1   1 
ATOM   1679 N NH2   . ARG   A 1 215 ? 29.959 -17.082 2.451  1    75.91  ?  394 ARG   A NH2   1 
ATOM   1680 N N     . VAL   A 1 216 ? 23.341 -13.059 3.355  1    62.05  ?  395 VAL   A N     1 
ATOM   1681 C CA    . VAL   A 1 216 ? 22.606 -13.617 4.502  1    62.04  ?  395 VAL   A CA    1 
ATOM   1682 C C     . VAL   A 1 216 ? 21.852 -14.875 4.067  1    61.65  ?  395 VAL   A C     1 
ATOM   1683 O O     . VAL   A 1 216 ? 21.857 -15.878 4.775  1    61.64  ?  395 VAL   A O     1 
ATOM   1684 C CB    . VAL   A 1 216 ? 21.618 -12.578 5.089  1    63.11  ?  395 VAL   A CB    1 
ATOM   1685 C CG1   . VAL   A 1 216 ? 20.838 -13.155 6.271  1    63.5   ?  395 VAL   A CG1   1 
ATOM   1686 C CG2   . VAL   A 1 216 ? 22.346 -11.308 5.49   1    63.97  ?  395 VAL   A CG2   1 
ATOM   1687 N N     . ILE   A 1 217 ? 21.257 -14.808 2.859  1    61.47  ?  396 ILE   A N     1 
ATOM   1688 C CA    . ILE   A 1 217 ? 20.514 -15.864 2.192  1    61.56  ?  396 ILE   A CA    1 
ATOM   1689 C C     . ILE   A 1 217 ? 21.4   -17.086 1.955  1    61.16  ?  396 ILE   A C     1 
ATOM   1690 O O     . ILE   A 1 217 ? 21.06  -18.162 2.449  1    61.27  ?  396 ILE   A O     1 
ATOM   1691 C CB    . ILE   A 1 217 ? 19.923 -15.288 0.88   1    62.41  ?  396 ILE   A CB    1 
ATOM   1692 C CG1   . ILE   A 1 217 ? 18.769 -14.334 1.164  1    63.25  ?  396 ILE   A CG1   1 
ATOM   1693 C CG2   . ILE   A 1 217 ? 19.539 -16.38  -0.126 1    63.16  ?  396 ILE   A CG2   1 
ATOM   1694 C CD1   . ILE   A 1 217 ? 18.582 -13.387 0.102  1    64.59  ?  396 ILE   A CD1   1 
ATOM   1695 N N     . THR   A 1 218 ? 22.553 -16.928 1.262  1    60.64  ?  397 THR   A N     1 
ATOM   1696 C CA    . THR   A 1 218 ? 23.417 -18.072 1      1    61.18  ?  397 THR   A CA    1 
ATOM   1697 C C     . THR   A 1 218 ? 24.01  -18.642 2.296  1    62.19  ?  397 THR   A C     1 
ATOM   1698 O O     . THR   A 1 218 ? 24.202 -19.857 2.374  1    61.9   ?  397 THR   A O     1 
ATOM   1699 C CB    . THR   A 1 218 ? 24.475 -17.771 -0.084 1    62.37  ?  397 THR   A CB    1 
ATOM   1700 O OG1   . THR   A 1 218 ? 25.468 -16.866 0.394  1    63.27  ?  397 THR   A OG1   1 
ATOM   1701 C CG2   . THR   A 1 218 ? 23.868 -17.246 -1.373 1    62.57  ?  397 THR   A CG2   1 
ATOM   1702 N N     . LEU   A 1 219 ? 24.246 -17.785 3.332  1    63.1   ?  398 LEU   A N     1 
ATOM   1703 C CA    . LEU   A 1 219 ? 24.804 -18.233 4.616  1    64.35  ?  398 LEU   A CA    1 
ATOM   1704 C C     . LEU   A 1 219 ? 23.837 -19.09  5.385  1    65.27  ?  398 LEU   A C     1 
ATOM   1705 O O     . LEU   A 1 219 ? 24.252 -20.076 5.975  1    65.17  ?  398 LEU   A O     1 
ATOM   1706 C CB    . LEU   A 1 219 ? 25.241 -17.071 5.507  1    64.97  ?  398 LEU   A CB    1 
ATOM   1707 C CG    . LEU   A 1 219 ? 26.61  -16.481 5.255  1    66.78  ?  398 LEU   A CG    1 
ATOM   1708 C CD1   . LEU   A 1 219 ? 26.873 -15.371 6.238  1    67.56  ?  398 LEU   A CD1   1 
ATOM   1709 C CD2   . LEU   A 1 219 ? 27.7   -17.538 5.364  1    67.49  ?  398 LEU   A CD2   1 
ATOM   1710 N N     . LYS   A 1 220 ? 22.546 -18.749 5.369  1    66.36  ?  399 LYS   A N     1 
ATOM   1711 C CA    . LYS   A 1 220 ? 21.519 -19.543 6.056  1    68.1   ?  399 LYS   A CA    1 
ATOM   1712 C C     . LYS   A 1 220 ? 21.527 -21.015 5.599  1    69.54  ?  399 LYS   A C     1 
ATOM   1713 O O     . LYS   A 1 220 ? 21.256 -21.911 6.396  1    69.7   ?  399 LYS   A O     1 
ATOM   1714 C CB    . LYS   A 1 220 ? 20.13  -18.921 5.841  1    70.08  ?  399 LYS   A CB    1 
ATOM   1715 N N     . MET   A 1 221 ? 21.899 -21.261 4.335  1    70.53  ?  400 MET   A N     1 
ATOM   1716 C CA    . MET   A 1 221 ? 21.976 -22.614 3.793  1    71.9   ?  400 MET   A CA    1 
ATOM   1717 C C     . MET   A 1 221 ? 23.223 -23.351 4.292  1    72.8   ?  400 MET   A C     1 
ATOM   1718 O O     . MET   A 1 221 ? 23.137 -24.52  4.658  1    73.03  ?  400 MET   A O     1 
ATOM   1719 C CB    . MET   A 1 221 ? 21.937 -22.576 2.257  1    73.07  ?  400 MET   A CB    1 
ATOM   1720 C CG    . MET   A 1 221 ? 20.71  -21.867 1.706  1    76.35  ?  400 MET   A CG    1 
ATOM   1721 S SD    . MET   A 1 221 ? 20.676 -21.795 -0.107 1    83.83  ?  400 MET   A SD    1 
ATOM   1722 C CE    . MET   A 1 221 ? 19.364 -20.595 -0.356 1    82.19  ?  400 MET   A CE    1 
ATOM   1723 N N     . GLU   A 1 222 ? 24.374 -22.664 4.328  1    73.21  ?  401 GLU   A N     1 
ATOM   1724 C CA    . GLU   A 1 222 ? 25.653 -23.228 4.768  1    73.82  ?  401 GLU   A CA    1 
ATOM   1725 C C     . GLU   A 1 222 ? 25.754 -23.466 6.276  1    74.2   ?  401 GLU   A C     1 
ATOM   1726 O O     . GLU   A 1 222 ? 26.36  -24.452 6.692  1    74.35  ?  401 GLU   A O     1 
ATOM   1727 C CB    . GLU   A 1 222 ? 26.813 -22.309 4.357  1    76.2   ?  401 GLU   A CB    1 
ATOM   1728 C CG    . GLU   A 1 222 ? 26.862 -21.967 2.884  1    82.1   ?  401 GLU   A CG    1 
ATOM   1729 C CD    . GLU   A 1 222 ? 28.081 -21.145 2.512  1    89.38  ?  401 GLU   A CD    1 
ATOM   1730 O OE1   . GLU   A 1 222 ? 27.925 -20.131 1.793  1    91.2   ?  401 GLU   A OE1   1 
ATOM   1731 O OE2   . GLU   A 1 222 ? 29.196 -21.511 2.951  1    91.14  ?  401 GLU   A OE2   1 
ATOM   1732 N N     . ILE   A 1 223 ? 25.246 -22.533 7.097  1    74.22  ?  402 ILE   A N     1 
ATOM   1733 C CA    . ILE   A 1 223 ? 25.371 -22.652 8.547  1    74.63  ?  402 ILE   A CA    1 
ATOM   1734 C C     . ILE   A 1 223 ? 24.54  -23.823 9.094  1    75.01  ?  402 ILE   A C     1 
ATOM   1735 O O     . ILE   A 1 223 ? 23.433 -24.087 8.614  1    75.01  ?  402 ILE   A O     1 
ATOM   1736 C CB    . ILE   A 1 223 ? 25.095 -21.309 9.277  1    74.99  ?  402 ILE   A CB    1 
ATOM   1737 C CG1   . ILE   A 1 223 ? 23.639 -20.837 9.118  1    76.06  ?  402 ILE   A CG1   1 
ATOM   1738 C CG2   . ILE   A 1 223 ? 26.084 -20.238 8.83   1    75.23  ?  402 ILE   A CG2   1 
ATOM   1739 C CD1   . ILE   A 1 223 ? 23.271 -19.62  9.99   1    77.25  ?  402 ILE   A CD1   1 
ATOM   1740 N N     . PRO   A 1 224 ? 25.113 -24.58  10.053 1    75.02  ?  403 PRO   A N     1 
ATOM   1741 C CA    . PRO   A 1 224 ? 24.397 -25.742 10.602 1    75.17  ?  403 PRO   A CA    1 
ATOM   1742 C C     . PRO   A 1 224 ? 23.063 -25.375 11.264 1    75.1   ?  403 PRO   A C     1 
ATOM   1743 O O     . PRO   A 1 224 ? 22.009 -25.706 10.717 1    75.69  ?  403 PRO   A O     1 
ATOM   1744 C CB    . PRO   A 1 224 ? 25.421 -26.383 11.563 1    75.97  ?  403 PRO   A CB    1 
ATOM   1745 C CG    . PRO   A 1 224 ? 26.748 -25.795 11.175 1    76.37  ?  403 PRO   A CG    1 
ATOM   1746 C CD    . PRO   A 1 224 ? 26.437 -24.417 10.68  1    74.67  ?  403 PRO   A CD    1 
ATOM   1747 N N     . GLY   A 1 225 ? 23.101 -24.656 12.384 1    74.06  ?  404 GLY   A N     1 
ATOM   1748 C CA    . GLY   A 1 225 ? 21.883 -24.213 13.048 1    73.33  ?  404 GLY   A CA    1 
ATOM   1749 C C     . GLY   A 1 225 ? 21.322 -22.951 12.421 1    72.19  ?  404 GLY   A C     1 
ATOM   1750 O O     . GLY   A 1 225 ? 21.899 -22.404 11.473 1    72.39  ?  404 GLY   A O     1 
ATOM   1751 N N     . SER   A 1 226 ? 20.184 -22.471 12.938 1    70.57  ?  405 SER   A N     1 
ATOM   1752 C CA    . SER   A 1 226 ? 19.576 -21.24  12.424 1    68.98  ?  405 SER   A CA    1 
ATOM   1753 C C     . SER   A 1 226 ? 20.387 -19.998 12.877 1    66.76  ?  405 SER   A C     1 
ATOM   1754 O O     . SER   A 1 226 ? 21.225 -20.09  13.782 1    66.72  ?  405 SER   A O     1 
ATOM   1755 C CB    . SER   A 1 226 ? 18.121 -21.132 12.885 1    70.18  ?  405 SER   A CB    1 
ATOM   1756 O OG    . SER   A 1 226 ? 17.34  -20.29  12.05  1    71.83  ?  405 SER   A OG    1 
ATOM   1757 N N     . MET   A 1 227 ? 20.146 -18.848 12.221 1    64.63  ?  406 MET   A N     1 
ATOM   1758 C CA    . MET   A 1 227 ? 20.782 -17.574 12.54  1    62.94  ?  406 MET   A CA    1 
ATOM   1759 C C     . MET   A 1 227 ? 20.463 -17.156 13.972 1    61.23  ?  406 MET   A C     1 
ATOM   1760 O O     . MET   A 1 227 ? 19.362 -17.425 14.466 1    61.32  ?  406 MET   A O     1 
ATOM   1761 C CB    . MET   A 1 227 ? 20.234 -16.487 11.603 1    63.15  ?  406 MET   A CB    1 
ATOM   1762 C CG    . MET   A 1 227 ? 20.837 -16.514 10.241 1    64.83  ?  406 MET   A CG    1 
ATOM   1763 S SD    . MET   A 1 227 ? 22.537 -15.915 10.259 1    65.45  ?  406 MET   A SD    1 
ATOM   1764 C CE    . MET   A 1 227 ? 22.73  -15.463 8.556  1    59.96  ?  406 MET   A CE    1 
ATOM   1765 N N     . PRO   A 1 228 ? 21.38  -16.427 14.638 1    59.31  ?  407 PRO   A N     1 
ATOM   1766 C CA    . PRO   A 1 228 ? 21.073 -15.929 15.99  1    58.07  ?  407 PRO   A CA    1 
ATOM   1767 C C     . PRO   A 1 228 ? 19.818 -15.037 15.988 1    56.64  ?  407 PRO   A C     1 
ATOM   1768 O O     . PRO   A 1 228 ? 19.536 -14.365 14.994 1    56.13  ?  407 PRO   A O     1 
ATOM   1769 C CB    . PRO   A 1 228 ? 22.338 -15.157 16.378 1    58.88  ?  407 PRO   A CB    1 
ATOM   1770 C CG    . PRO   A 1 228 ? 23.415 -15.728 15.498 1    59.61  ?  407 PRO   A CG    1 
ATOM   1771 C CD    . PRO   A 1 228 ? 22.724 -16.009 14.2   1    58.39  ?  407 PRO   A CD    1 
ATOM   1772 N N     . PRO   A 1 229 ? 19.01  -15.106 17.061 1    55.66  ?  408 PRO   A N     1 
ATOM   1773 C CA    . PRO   A 1 229 ? 17.728 -14.373 17.084 1    55.14  ?  408 PRO   A CA    1 
ATOM   1774 C C     . PRO   A 1 229 ? 17.759 -12.921 16.599 1    54.19  ?  408 PRO   A C     1 
ATOM   1775 O O     . PRO   A 1 229 ? 17.068 -12.62  15.633 1    54.49  ?  408 PRO   A O     1 
ATOM   1776 C CB    . PRO   A 1 229 ? 17.286 -14.48  18.547 1    55.83  ?  408 PRO   A CB    1 
ATOM   1777 C CG    . PRO   A 1 229 ? 17.89  -15.75  19.02  1    56.38  ?  408 PRO   A CG    1 
ATOM   1778 C CD    . PRO   A 1 229 ? 19.188 -15.927 18.276 1    54.94  ?  408 PRO   A CD    1 
ATOM   1779 N N     . LEU   A 1 230 ? 18.579 -12.048 17.212 1    52.87  ?  409 LEU   A N     1 
ATOM   1780 C CA    . LEU   A 1 230 ? 18.665 -10.634 16.852 1    52.07  ?  409 LEU   A CA    1 
ATOM   1781 C C     . LEU   A 1 230 ? 19.066 -10.395 15.408 1    51.59  ?  409 LEU   A C     1 
ATOM   1782 O O     . LEU   A 1 230 ? 18.481 -9.532  14.768 1    51.85  ?  409 LEU   A O     1 
ATOM   1783 C CB    . LEU   A 1 230 ? 19.584 -9.867  17.818 1    51.79  ?  409 LEU   A CB    1 
ATOM   1784 C CG    . LEU   A 1 230 ? 19.53  -8.345  17.762 1    52.51  ?  409 LEU   A CG    1 
ATOM   1785 C CD1   . LEU   A 1 230 ? 18.093 -7.811  17.836 1    52.78  ?  409 LEU   A CD1   1 
ATOM   1786 C CD2   . LEU   A 1 230 ? 20.355 -7.744  18.865 1    53     ?  409 LEU   A CD2   1 
ATOM   1787 N N     . ILE   A 1 231 ? 19.999 -11.187 14.87  1    50.95  ?  410 ILE   A N     1 
ATOM   1788 C CA    . ILE   A 1 231 ? 20.414 -11.067 13.476 1    50.9   ?  410 ILE   A CA    1 
ATOM   1789 C C     . ILE   A 1 231 ? 19.228 -11.375 12.55  1    51.71  ?  410 ILE   A C     1 
ATOM   1790 O O     . ILE   A 1 231 ? 19.016 -10.671 11.556 1    51.18  ?  410 ILE   A O     1 
ATOM   1791 C CB    . ILE   A 1 231 ? 21.646 -11.975 13.196 1    50.65  ?  410 ILE   A CB    1 
ATOM   1792 C CG1   . ILE   A 1 231 ? 22.927 -11.395 13.848 1    51.13  ?  410 ILE   A CG1   1 
ATOM   1793 C CG2   . ILE   A 1 231 ? 21.859 -12.204 11.698 1    50.7   ?  410 ILE   A CG2   1 
ATOM   1794 C CD1   . ILE   A 1 231 ? 24.106 -12.325 13.84  1    51.98  ?  410 ILE   A CD1   1 
ATOM   1795 N N     . GLN   A 1 232 ? 18.454 -12.418 12.889 1    52.77  ?  411 GLN   A N     1 
ATOM   1796 C CA    . GLN   A 1 232 ? 17.277 -12.827 12.119 1    54.36  ?  411 GLN   A CA    1 
ATOM   1797 C C     . GLN   A 1 232 ? 16.239 -11.699 12.103 1    54.28  ?  411 GLN   A C     1 
ATOM   1798 O O     . GLN   A 1 232 ? 15.661 -11.419 11.063 1    54.5   ?  411 GLN   A O     1 
ATOM   1799 C CB    . GLN   A 1 232 ? 16.674 -14.115 12.704 1    57.42  ?  411 GLN   A CB    1 
ATOM   1800 C CG    . GLN   A 1 232 ? 15.715 -14.826 11.756 1    63.45  ?  411 GLN   A CG    1 
ATOM   1801 C CD    . GLN   A 1 232 ? 16.334 -16.069 11.152 1    70.63  ?  411 GLN   A CD    1 
ATOM   1802 O OE1   . GLN   A 1 232 ? 16.813 -16.966 11.865 1    72.72  ?  411 GLN   A OE1   1 
ATOM   1803 N NE2   . GLN   A 1 232 ? 16.33  -16.154 9.82   1    71.76  ?  411 GLN   A NE2   1 
ATOM   1804 N N     . GLU   A 1 233 ? 16.042 -11.027 13.243 1    54.05  ?  412 GLU   A N     1 
ATOM   1805 C CA    . GLU   A 1 233 ? 15.123 -9.902  13.371 1    54.82  ?  412 GLU   A CA    1 
ATOM   1806 C C     . GLU   A 1 233 ? 15.554 -8.725  12.469 1    55.36  ?  412 GLU   A C     1 
ATOM   1807 O O     . GLU   A 1 233 ? 14.734 -8.187  11.723 1    55.6   ?  412 GLU   A O     1 
ATOM   1808 C CB    . GLU   A 1 233 ? 15.074 -9.444  14.838 1    57.93  ?  412 GLU   A CB    1 
ATOM   1809 C CG    . GLU   A 1 233 ? 13.68  -9.206  15.384 1    64.61  ?  412 GLU   A CG    1 
ATOM   1810 C CD    . GLU   A 1 233 ? 13.622 -9.17   16.899 1    73.18  ?  412 GLU   A CD    1 
ATOM   1811 O OE1   . GLU   A 1 233 ? 13.299 -10.21  17.521 1    75.62  ?  412 GLU   A OE1   1 
ATOM   1812 O OE2   . GLU   A 1 233 ? 13.91  -8.095  17.468 1    75.46  ?  412 GLU   A OE2   1 
ATOM   1813 N N     . MET   A 1 234 ? 16.845 -8.346  12.516 1    55.11  ?  413 MET   A N     1 
ATOM   1814 C CA    . MET   A 1 234 ? 17.366 -7.224  11.753 1    55.23  ?  413 MET   A CA    1 
ATOM   1815 C C     . MET   A 1 234 ? 17.45  -7.454  10.26  1    56.61  ?  413 MET   A C     1 
ATOM   1816 O O     . MET   A 1 234 ? 17.273 -6.503  9.492  1    56.25  ?  413 MET   A O     1 
ATOM   1817 C CB    . MET   A 1 234 ? 18.753 -6.824  12.272 1    55.01  ?  413 MET   A CB    1 
ATOM   1818 C CG    . MET   A 1 234 ? 18.773 -6.455  13.733 1    56.25  ?  413 MET   A CG    1 
ATOM   1819 S SD    . MET   A 1 234 ? 17.797 -4.996  14.161 1    58.82  ?  413 MET   A SD    1 
ATOM   1820 C CE    . MET   A 1 234 ? 18.623 -3.801  13.228 1    55.3   ?  413 MET   A CE    1 
ATOM   1821 N N     . LEU   A 1 235 ? 17.774 -8.686  9.831  1    58.16  ?  414 LEU   A N     1 
ATOM   1822 C CA    . LEU   A 1 235 ? 17.996 -8.937  8.406  1    60.27  ?  414 LEU   A CA    1 
ATOM   1823 C C     . LEU   A 1 235 ? 16.952 -9.802  7.713  1    62.3   ?  414 LEU   A C     1 
ATOM   1824 O O     . LEU   A 1 235 ? 17.099 -10.059 6.521  1    62.41  ?  414 LEU   A O     1 
ATOM   1825 C CB    . LEU   A 1 235 ? 19.395 -9.512  8.17   1    60.67  ?  414 LEU   A CB    1 
ATOM   1826 C CG    . LEU   A 1 235 ? 20.542 -8.709  8.793  1    62.3   ?  414 LEU   A CG    1 
ATOM   1827 C CD1   . LEU   A 1 235 ? 21.883 -9.394  8.56   1    62.98  ?  414 LEU   A CD1   1 
ATOM   1828 C CD2   . LEU   A 1 235 ? 20.566 -7.279  8.273  1    62.84  ?  414 LEU   A CD2   1 
ATOM   1829 N N     . GLU   A 1 236 ? 15.895 -10.219 8.42   1    63.61  ?  415 GLU   A N     1 
ATOM   1830 C CA    . GLU   A 1 236 ? 14.818 -10.981 7.789  1    65.37  ?  415 GLU   A CA    1 
ATOM   1831 C C     . GLU   A 1 236 ? 13.483 -10.283 8.007  1    66.3   ?  415 GLU   A C     1 
ATOM   1832 O O     . GLU   A 1 236 ? 13.415 -9.06   7.87   1    66.86  ?  415 GLU   A O     1 
ATOM   1833 C CB    . GLU   A 1 236 ? 14.778 -12.452 8.251  1    68.23  ?  415 GLU   A CB    1 
ATOM   1834 C CG    . GLU   A 1 236 ? 15.928 -13.29  7.716  1    73.93  ?  415 GLU   A CG    1 
ATOM   1835 C CD    . GLU   A 1 236 ? 16.058 -13.311 6.203  1    81.44  ?  415 GLU   A CD    1 
ATOM   1836 O OE1   . GLU   A 1 236 ? 15.018 -13.41  5.508  1    82.59  ?  415 GLU   A OE1   1 
ATOM   1837 O OE2   . GLU   A 1 236 ? 17.209 -13.23  5.712  1    83.48  ?  415 GLU   A OE2   1 
ATOM   1838 N N     . HIS   B 2 1   ? 9.72   -9.111  16.263 1    70.54  ?  1   HIS   B N     1 
ATOM   1839 C CA    . HIS   B 2 1   ? 10.304 -7.812  16.64  1    70.21  ?  1   HIS   B CA    1 
ATOM   1840 C C     . HIS   B 2 1   ? 10.563 -7.417  18.054 1    69.32  ?  1   HIS   B C     1 
ATOM   1841 O O     . HIS   B 2 1   ? 11.195 -6.377  18.315 1    69.52  ?  1   HIS   B O     1 
ATOM   1842 C CB    . HIS   B 2 1   ? 10.714 -6.771  15.651 1    70.62  ?  1   HIS   B CB    1 
ATOM   1843 C CG    . HIS   B 2 1   ? 9.638  -6.163  14.791 1    71.16  ?  1   HIS   B CG    1 
ATOM   1844 N ND1   . HIS   B 2 1   ? 8.582  -5.609  15.238 1    71.44  ?  1   HIS   B ND1   1 
ATOM   1845 C CD2   . HIS   B 2 1   ? 9.82   -6.197  13.312 1    71.37  ?  1   HIS   B CD2   1 
ATOM   1846 C CE1   . HIS   B 2 1   ? 7.867  -5.161  14.055 1    71.46  ?  1   HIS   B CE1   1 
ATOM   1847 N NE2   . HIS   B 2 1   ? 8.618  -5.518  12.879 1    71.53  ?  1   HIS   B NE2   1 
ATOM   1848 N N     . LYS   B 2 2   ? 9.994  -8.276  18.946 1    68.08  ?  2   LYS   B N     1 
ATOM   1849 C CA    . LYS   B 2 2   ? 10.638 -8.786  20.036 1    66.91  ?  2   LYS   B CA    1 
ATOM   1850 C C     . LYS   B 2 2   ? 11.757 -8.052  20.661 1    64.82  ?  2   LYS   B C     1 
ATOM   1851 O O     . LYS   B 2 2   ? 11.51  -7.058  21.371 1    64.62  ?  2   LYS   B O     1 
ATOM   1852 C CB    . LYS   B 2 2   ? 10.202 -10.063 20.651 1    67.65  ?  2   LYS   B CB    1 
ATOM   1853 C CG    . LYS   B 2 2   ? 10.24  -11.398 19.941 1    68.2   ?  2   LYS   B CG    1 
ATOM   1854 C CD    . LYS   B 2 2   ? 9.928  -12.485 20.949 1    68.66  ?  2   LYS   B CD    1 
ATOM   1855 C CE    . LYS   B 2 2   ? 8.516  -12.397 21.506 1    68.97  ?  2   LYS   B CE    1 
ATOM   1856 N NZ    . LYS   B 2 2   ? 7.779  -13.078 20.416 1    69.15  1  2   LYS   B NZ    1 
ATOM   1857 N N     . ILE   B 2 3   ? 12.967 -8.615  20.422 1    63.04  ?  3   ILE   B N     1 
ATOM   1858 C CA    . ILE   B 2 3   ? 14.169 -8.041  20.672 1    61.28  ?  3   ILE   B CA    1 
ATOM   1859 C C     . ILE   B 2 3   ? 14.514 -6.608  20.613 1    59.34  ?  3   ILE   B C     1 
ATOM   1860 O O     . ILE   B 2 3   ? 14.605 -5.973  21.678 1    58.54  ?  3   ILE   B O     1 
ATOM   1861 C CB    . ILE   B 2 3   ? 15.207 -9.04   20.942 1    61.36  ?  3   ILE   B CB    1 
ATOM   1862 C CG1   . ILE   B 2 3   ? 15.255 -10.322 20.156 1    61.26  ?  3   ILE   B CG1   1 
ATOM   1863 C CG2   . ILE   B 2 3   ? 16.27  -8.753  21.949 1    61.32  ?  3   ILE   B CG2   1 
ATOM   1864 C CD1   . ILE   B 2 3   ? 15.72  -11.571 20.859 1    61.07  ?  3   ILE   B CD1   1 
ATOM   1865 N N     . LEU   B 2 4   ? 14.685 -6.121  19.377 1    58.66  ?  4   LEU   B N     1 
ATOM   1866 C CA    . LEU   B 2 4   ? 14.143 -4.995  18.969 1    58.37  ?  4   LEU   B CA    1 
ATOM   1867 C C     . LEU   B 2 4   ? 13.418 -3.921  19.647 1    58.94  ?  4   LEU   B C     1 
ATOM   1868 O O     . LEU   B 2 4   ? 14.089 -2.969  20.085 1    58.29  ?  4   LEU   B O     1 
ATOM   1869 C CB    . LEU   B 2 4   ? 14.243 -4.897  17.483 1    57.67  ?  4   LEU   B CB    1 
ATOM   1870 C CG    . LEU   B 2 4   ? 15.043 -3.875  16.779 1    57.02  ?  4   LEU   B CG    1 
ATOM   1871 C CD1   . LEU   B 2 4   ? 16.191 -3.16   17.356 1    56.84  ?  4   LEU   B CD1   1 
ATOM   1872 C CD2   . LEU   B 2 4   ? 14.706 -3.513  15.392 1    56.72  ?  4   LEU   B CD2   1 
HETATM 1873 N N     . NLE   B 2 5   ? 12.062 -4.103  19.732 1    60.23  ?  5   NLE   B N     1 
HETATM 1874 C CA    . NLE   B 2 5   ? 11.313 -3.616  20.738 1    61.78  ?  5   NLE   B CA    1 
HETATM 1875 C C     . NLE   B 2 5   ? 11.794 -3.389  22.091 1    62.11  ?  5   NLE   B C     1 
HETATM 1876 O O     . NLE   B 2 5   ? 11.72  -2.232  22.538 1    61.73  ?  5   NLE   B O     1 
HETATM 1877 C CB    . NLE   B 2 5   ? 9.874  -3.3    20.548 1    63.16  ?  5   NLE   B CB    1 
HETATM 1878 C CG    . NLE   B 2 5   ? 9.133  -3.865  19.363 1    64.6   ?  5   NLE   B CG    1 
HETATM 1879 C CD    . NLE   B 2 5   ? 7.71   -4.253  19.74  1    65.86  ?  5   NLE   B CD    1 
HETATM 1880 C CE    . NLE   B 2 5   ? 6.761  -3.125  19.398 1    66.98  ?  5   NLE   B CE    1 
ATOM   1881 N N     . ARG   B 2 6   ? 12.253 -4.493  22.723 1    62.85  ?  6   ARG   B N     1 
ATOM   1882 C CA    . ARG   B 2 6   ? 12.905 -4.339  23.873 1    63.55  ?  6   ARG   B CA    1 
ATOM   1883 C C     . ARG   B 2 6   ? 13.883 -3.307  24.261 1    63.51  ?  6   ARG   B C     1 
ATOM   1884 O O     . ARG   B 2 6   ? 13.44  -2.37   24.946 1    63.32  ?  6   ARG   B O     1 
ATOM   1885 C CB    . ARG   B 2 6   ? 12.587 -5.407  24.881 1    64.64  ?  6   ARG   B CB    1 
ATOM   1886 C CG    . ARG   B 2 6   ? 13.558 -5.571  26.048 1    65.59  ?  6   ARG   B CG    1 
ATOM   1887 C CD    . ARG   B 2 6   ? 14.266 -6.92   25.988 1    66.4   ?  6   ARG   B CD    1 
ATOM   1888 N NE    . ARG   B 2 6   ? 13.275 -7.994  26.164 1    66.98  ?  6   ARG   B NE    1 
ATOM   1889 C CZ    . ARG   B 2 6   ? 13.285 -8.826  25.197 1    67.52  ?  6   ARG   B CZ    1 
ATOM   1890 N NH1   . ARG   B 2 6   ? 14.345 -9.634  24.834 1    67.78  ?  6   ARG   B NH1   1 
ATOM   1891 N NH2   . ARG   B 2 6   ? 12.173 -8.978  24.396 1    67.61  ?  6   ARG   B NH2   1 
ATOM   1892 N N     . LEU   B 2 7   ? 15.165 -3.459  23.807 1    63.56  ?  7   LEU   B N     1 
ATOM   1893 C CA    . LEU   B 2 7   ? 15.8   -2.581  22.999 1    63.35  ?  7   LEU   B CA    1 
ATOM   1894 C C     . LEU   B 2 7   ? 15.41  -1.181  22.816 1    63.36  ?  7   LEU   B C     1 
ATOM   1895 O O     . LEU   B 2 7   ? 15.978 -0.38   23.581 1    63.21  ?  7   LEU   B O     1 
ATOM   1896 C CB    . LEU   B 2 7   ? 16.966 -2.899  22.136 1    63.13  ?  7   LEU   B CB    1 
ATOM   1897 C CG    . LEU   B 2 7   ? 17.834 -4.081  22.308 1    63.09  ?  7   LEU   B CG    1 
ATOM   1898 C CD1   . LEU   B 2 7   ? 18.12  -4.996  21.172 1    63.23  ?  7   LEU   B CD1   1 
ATOM   1899 C CD2   . LEU   B 2 7   ? 18.457 -4.288  23.639 1    62.96  ?  7   LEU   B CD2   1 
ATOM   1900 N N     . LEU   B 2 8   ? 14.529 -0.892  21.834 1    63.82  ?  8   LEU   B N     1 
ATOM   1901 C CA    . LEU   B 2 8   ? 13.744 0.194   21.739 1    64.85  ?  8   LEU   B CA    1 
ATOM   1902 C C     . LEU   B 2 8   ? 13.264 1.046   22.83  1    67.11  ?  8   LEU   B C     1 
ATOM   1903 O O     . LEU   B 2 8   ? 13.982 1.99    23.211 1    67.23  ?  8   LEU   B O     1 
ATOM   1904 C CB    . LEU   B 2 8   ? 13.166 0.582   20.422 1    63.78  ?  8   LEU   B CB    1 
ATOM   1905 C CG    . LEU   B 2 8   ? 14.03  0.585   19.214 1    62.85  ?  8   LEU   B CG    1 
ATOM   1906 C CD1   . LEU   B 2 8   ? 13.565 -0.217  18.078 1    62.54  ?  8   LEU   B CD1   1 
ATOM   1907 C CD2   . LEU   B 2 8   ? 15.276 1.384   19.119 1    62.29  ?  8   LEU   B CD2   1 
HETATM 1908 N N     . HRG   B 2 9   ? 12.058 0.694   23.318 1    69.08  ?  9   HRG   B N     1 
HETATM 1909 C CA    . HRG   B 2 9   ? 11.518 0.673   24.553 1    70.69  ?  9   HRG   B CA    1 
HETATM 1910 C CB    . HRG   B 2 9   ? 10.011 0.632   24.588 1    70.36  ?  9   HRG   B CB    1 
HETATM 1911 C CG    . HRG   B 2 9   ? 7.838  -0.121  23.479 1    69.68  ?  9   HRG   B CG    1 
HETATM 1912 C "CG'" . HRG   B 2 9   ? 9.339  -0.324  23.603 1    70.11  ?  9   HRG   B "CG'" 1 
HETATM 1913 C CD    . HRG   B 2 9   ? 7.385  -1.191  22.507 1    69.28  ?  9   HRG   B CD    1 
HETATM 1914 N NE    . HRG   B 2 9   ? 6.302  -0.646  21.656 1    68.96  ?  9   HRG   B NE    1 
HETATM 1915 C CZ    . HRG   B 2 9   ? 5.847  -1.368  20.7   1    68.44  ?  9   HRG   B CZ    1 
HETATM 1916 N NH1   . HRG   B 2 9   ? 5.104  -0.77   19.696 1    68.25  ?  9   HRG   B NH1   1 
HETATM 1917 N NH2   . HRG   B 2 9   ? 5.934  -2.707  20.534 1    67.93  ?  9   HRG   B NH2   1 
HETATM 1918 C C     . HRG   B 2 9   ? 12.183 0.715   25.873 1    72.38  ?  9   HRG   B C     1 
HETATM 1919 O O     . HRG   B 2 9   ? 12.336 -0.367  26.47  1    72.61  ?  9   HRG   B O     1 
HETATM 1920 C C17   . A1IM7 B 2 10  ? 14.244 5.92    27.277 1    75.94  ?  10  A1IM7 B C17   1 
HETATM 1921 N N     . A1IM7 B 2 10  ? 12.552 1.932   26.329 1    73.81  ?  10  A1IM7 B N     1 
HETATM 1922 C CA    . A1IM7 B 2 10  ? 13.747 2.266   26.865 1    74.97  ?  10  A1IM7 B CA    1 
HETATM 1923 C C     . A1IM7 B 2 10  ? 13.812 3.592   27.534 1    75.63  ?  10  A1IM7 B C     1 
HETATM 1924 O O     . A1IM7 B 2 10  ? 13.821 3.653   28.783 1    75.65  ?  10  A1IM7 B O     1 
HETATM 1925 C CB    . A1IM7 B 2 10  ? 14.908 1.339   26.756 1    75.37  ?  10  A1IM7 B CB    1 
HETATM 1926 C CG    . A1IM7 B 2 10  ? 15.5   0.8     28.039 1    75.83  ?  10  A1IM7 B CG    1 
HETATM 1927 C CD    . A1IM7 B 2 10  ? 15.176 -0.528  28.699 1    76.15  ?  10  A1IM7 B CD    1 
HETATM 1928 O OE1   . A1IM7 B 2 10  ? 15.779 -1.523  28.236 1    76.22  -1 10  A1IM7 B OE1   1 
HETATM 1929 O OE2   . A1IM7 B 2 10  ? 14.355 -0.546  29.638 1    76.16  ?  10  A1IM7 B OE2   1 
HETATM 1930 N N12   . A1IM7 B 2 10  ? 13.841 4.659   26.68  1    75.87  ?  10  A1IM7 B N12   1 
HETATM 1931 C CAA   . EQN   C 3 .   ? 25.097 -9.982  10.421 1    32.5   ?  501 EQN   A CAA   1 
HETATM 1932 C CAB   . EQN   C 3 .   ? 26.75  -11.829 10.442 1    32.24  ?  501 EQN   A CAB   1 
HETATM 1933 C CAC   . EQN   C 3 .   ? 26.046 -10.104 5.677  1    31     ?  501 EQN   A CAC   1 
HETATM 1934 C CAD   . EQN   C 3 .   ? 28.022 -11.498 5.879  1    31.38  ?  501 EQN   A CAD   1 
HETATM 1935 O OAE   . EQN   C 3 .   ? 32.845 -5.581  16.713 1    29.15  ?  501 EQN   A OAE   1 
HETATM 1936 O OAF   . EQN   C 3 .   ? 30.203 -6.295  9.767  1    31.28  ?  501 EQN   A OAF   1 
HETATM 1937 O OAG   . EQN   C 3 .   ? 32.989 -3.772  15.462 1    29.89  ?  501 EQN   A OAG   1 
HETATM 1938 C CAH   . EQN   C 3 .   ? 30.743 -5.635  12.447 1    28.17  ?  501 EQN   A CAH   1 
HETATM 1939 C CAI   . EQN   C 3 .   ? 30.587 -7.483  13.798 1    28.34  ?  501 EQN   A CAI   1 
HETATM 1940 C CAJ   . EQN   C 3 .   ? 31.424 -4.958  13.441 1    28.41  ?  501 EQN   A CAJ   1 
HETATM 1941 C CAK   . EQN   C 3 .   ? 31.264 -6.846  14.817 1    28.33  ?  501 EQN   A CAK   1 
HETATM 1942 C CAL   . EQN   C 3 .   ? 29.125 -8.133  8.094  1    31.58  ?  501 EQN   A CAL   1 
HETATM 1943 C CAM   . EQN   C 3 .   ? 28.473 -8.971  7.207  1    31.62  ?  501 EQN   A CAM   1 
HETATM 1944 C CAN   . EQN   C 3 .   ? 27.841 -9.002  9.881  1    31.52  ?  501 EQN   A CAN   1 
HETATM 1945 C CAO   . EQN   C 3 .   ? 25.305 -11.462 8.478  1    32.52  ?  501 EQN   A CAO   1 
HETATM 1946 C CAP   . EQN   C 3 .   ? 26.179 -11.954 7.34   1    31.86  ?  501 EQN   A CAP   1 
HETATM 1947 N NAQ   . EQN   C 3 .   ? 29.536 -7.547  11.618 1    29.69  ?  501 EQN   A NAQ   1 
HETATM 1948 C CAR   . EQN   C 3 .   ? 32.581 -4.93   15.685 1    29.09  ?  501 EQN   A CAR   1 
HETATM 1949 C CAS   . EQN   C 3 .   ? 29.592 -7.237  10.292 1    30.5   ?  501 EQN   A CAS   1 
HETATM 1950 C CAT   . EQN   C 3 .   ? 30.281 -6.911  12.599 1    28.33  ?  501 EQN   A CAT   1 
HETATM 1951 C CAU   . EQN   C 3 .   ? 31.724 -5.579  14.632 1    28.46  ?  501 EQN   A CAU   1 
HETATM 1952 C CAV   . EQN   C 3 .   ? 28.82  -8.147  9.423  1    31.19  ?  501 EQN   A CAV   1 
HETATM 1953 C CAW   . EQN   C 3 .   ? 27.51  -9.838  7.658  1    31.55  ?  501 EQN   A CAW   1 
HETATM 1954 C CAX   . EQN   C 3 .   ? 27.181 -9.85   9.002  1    31.92  ?  501 EQN   A CAX   1 
HETATM 1955 C CAY   . EQN   C 3 .   ? 26.11  -10.773 9.564  1    32.52  ?  501 EQN   A CAY   1 
HETATM 1956 C CAZ   . EQN   C 3 .   ? 26.931 -10.83  6.669  1    31.29  ?  501 EQN   A CAZ   1 
HETATM 1957 O O     . HOH   D 4 .   ? 21.852 -2.387  5.88   1    39.11  ?  601 HOH   A O     1 
HETATM 1958 O O     . HOH   D 4 .   ? 34.046 -8.991  -2.96  1    50.41  ?  602 HOH   A O     1 
HETATM 1959 O O     . HOH   D 4 .   ? 35.815 5.323   19.724 1    45.98  ?  603 HOH   A O     1 
HETATM 1960 O O     . HOH   D 4 .   ? 39.171 7.568   7.256  1    50.53  ?  604 HOH   A O     1 
HETATM 1961 O O     . HOH   D 4 .   ? 32.417 -17.591 4.002  1    54.3   ?  605 HOH   A O     1 
HETATM 1962 O O     . HOH   D 4 .   ? 7.821  2.128   9.296  1    47.14  ?  606 HOH   A O     1 
HETATM 1963 O O     . HOH   D 4 .   ? 42.512 -2.756  25.68  1    34.36  ?  607 HOH   A O     1 
HETATM 1964 O O     . HOH   D 4 .   ? 13.792 -1.549  6.956  1    48.95  ?  608 HOH   A O     1 
HETATM 1965 O O     . HOH   D 4 .   ? 8.025  8.351   12.31  1    36.08  ?  609 HOH   A O     1 
HETATM 1966 O O     . HOH   D 4 .   ? 41.145 -8.119  23.752 1    38.36  ?  610 HOH   A O     1 
HETATM 1967 O O     . HOH   D 4 .   ? 45.12  0.904   10.989 1    58.02  ?  611 HOH   A O     1 
HETATM 1968 O O     . HOH   D 4 .   ? 17.041 10.016  20.404 1    41.07  ?  612 HOH   A O     1 
HETATM 1969 O O     . HOH   D 4 .   ? 30.875 -6.417  18.547 1    36.66  ?  613 HOH   A O     1 
HETATM 1970 O O     . HOH   D 4 .   ? 20.555 -4.023  6.976  1    43.56  ?  614 HOH   A O     1 
HETATM 1971 O O     . HOH   D 4 .   ? 15.189 20.065  8.114  1    64.19  ?  615 HOH   A O     1 
HETATM 1972 O O     . HOH   D 4 .   ? 17.766 3.545   7.649  1    32.12  ?  616 HOH   A O     1 
HETATM 1973 O O     . HOH   D 4 .   ? 32.331 13.741  22.552 1    67.42  ?  617 HOH   A O     1 
HETATM 1974 O O     . HOH   D 4 .   ? 43.241 -14.15  13.373 1    40.45  ?  618 HOH   A O     1 
HETATM 1975 O O     . HOH   D 4 .   ? 43.012 -4.702  12.226 1    35.55  ?  619 HOH   A O     1 
HETATM 1976 O O     . HOH   D 4 .   ? 48.383 -17.145 9.238  1    58.24  ?  620 HOH   A O     1 
HETATM 1977 O O     . HOH   D 4 .   ? 45.504 -1.871  19.223 1    44.31  ?  621 HOH   A O     1 
HETATM 1978 O O     . HOH   D 4 .   ? 39.821 -5.619  -2.069 1    52.56  ?  622 HOH   A O     1 
HETATM 1979 O O     . HOH   D 4 .   ? 21.117 0.067   3.298  1    45.6   ?  623 HOH   A O     1 
HETATM 1980 O O     . HOH   D 4 .   ? 26.259 -3.483  25.032 1    53.62  ?  624 HOH   A O     1 
HETATM 1981 O O     . HOH   D 4 .   ? 26.952 -4.962  22.956 1    38.18  ?  625 HOH   A O     1 
HETATM 1982 O O     . HOH   D 4 .   ? 46.898 -6.625  12.288 1    44.8   ?  626 HOH   A O     1 
HETATM 1983 O O     . HOH   D 4 .   ? 10.086 6.317   2.108  1    56.34  ?  627 HOH   A O     1 
HETATM 1984 O O     . HOH   D 4 .   ? 30.928 -19.237 0.913  1    60.37  ?  628 HOH   A O     1 
HETATM 1985 O O     . HOH   D 4 .   ? 8.56   -1.542  11.97  1    47.83  ?  629 HOH   A O     1 
HETATM 1986 O O     . HOH   D 4 .   ? 12.973 -0.689  4.494  1    57.47  ?  630 HOH   A O     1 
HETATM 1987 O O     . HOH   D 4 .   ? 28.81  4.277   14.329 1    47.94  ?  631 HOH   A O     1 
HETATM 1988 O O     . HOH   D 4 .   ? 41.770 -11.104 -2.316 1    38.74  ?  632 HOH   A O     1 
HETATM 1989 O O     . HOH   D 4 .   ? 44.724 -13.066 4.345  1    43.55  ?  633 HOH   A O     1 
HETATM 1990 O O     . HOH   D 4 .   ? 25.189 12.164  22.975 1    61.14  ?  634 HOH   A O     1 
HETATM 1991 O O     . HOH   D 4 .   ? 25.482 18.582  22.833 1    52.41  ?  635 HOH   A O     1 
HETATM 1992 O O     . HOH   D 4 .   ? 43.726 -20.498 17.628 1    59.12  ?  636 HOH   A O     1 
HETATM 1993 O O     . HOH   D 4 .   ? 31.187 -1.458  18.517 1    53.73  ?  637 HOH   A O     1 
HETATM 1994 O O     . HOH   D 4 .   ? 1.566  8.412   7.758  1    55.89  ?  638 HOH   A O     1 
HETATM 1995 O O     . HOH   D 4 .   ? 46.096 -15.411 4.666  1    66.41  ?  639 HOH   A O     1 
HETATM 1996 O O     . HOH   D 4 .   ? 17.304 15.063  4.058  1    49.87  ?  640 HOH   A O     1 
HETATM 1997 O O     . HOH   D 4 .   ? 39.727 2.926   15.301 1    35.92  ?  641 HOH   A O     1 
HETATM 1998 O O     . HOH   D 4 .   ? 27.354 -13.142 24.923 1    44.75  ?  642 HOH   A O     1 
HETATM 1999 O O     . HOH   D 4 .   ? 40.909 -5.138  24.453 1    40.27  ?  643 HOH   A O     1 
HETATM 2000 O O     . HOH   D 4 .   ? 15.263 12.24   20.888 1    71.43  ?  644 HOH   A O     1 
HETATM 2001 O O     . HOH   D 4 .   ? 5.426  4.812   18.501 1    49.3   ?  645 HOH   A O     1 
HETATM 2002 O O     . HOH   D 4 .   ? 46.907 -16.579 12.677 1    51.13  ?  646 HOH   A O     1 
HETATM 2003 O O     . HOH   D 4 .   ? 37.662 6.485   21.987 1    63.53  ?  647 HOH   A O     1 
HETATM 2004 O O     . HOH   D 4 .   ? 46.867 -4.163  20.13  1    29.32  ?  648 HOH   A O     1 
HETATM 2005 O O     . HOH   D 4 .   ? 41.609 -24.709 11.102 1    61.95  ?  649 HOH   A O     1 
HETATM 2006 O O     . HOH   D 4 .   ? 32.416 -14.103 20.006 1    51.26  ?  650 HOH   A O     1 
HETATM 2007 O O     . HOH   D 4 .   ? 14.651 -0.058  2.576  1    57.99  ?  651 HOH   A O     1 
HETATM 2008 O O     . HOH   D 4 .   ? 42.47  4.258   16.635 1    56.75  ?  652 HOH   A O     1 
HETATM 2009 O O     . HOH   D 4 .   ? 20.59  -4.384  3.878  1    50.67  ?  653 HOH   A O     1 
HETATM 2010 O O     . HOH   D 4 .   ? 44.103 -4.806  26.006 1    51.77  ?  654 HOH   A O     1 
HETATM 2011 O O     . HOH   D 4 .   ? 15.353 -3.745  5.379  1    57.17  ?  655 HOH   A O     1 
# 
