data_9GBM
# 
_entry.id   9GBM 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9GBM         pdb_00009gbm 10.2210/pdb9gbm/pdb 
WWPDB D_1292139989 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-01-22 ? 
2 'Structure model' 1 1 2025-03-19 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume'          
2 2 'Structure model' '_citation.page_first'              
3 2 'Structure model' '_citation.page_last'               
4 2 'Structure model' '_citation_author.identifier_ORCID' 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9GBM 
_pdbx_database_status.recvd_initial_deposition_date   2024-07-31 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_contact_author.id                 3 
_pdbx_contact_author.email              bsskra@bath.ac.uk 
_pdbx_contact_author.name_first         K.Ravi 
_pdbx_contact_author.name_last          Acharya 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-3009-4058 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Gregory, K.S.' 1 ? 
'Cozier, G.E.'  2 ? 
'Acharya, K.R.' 3 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Febs J.' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           1742-464X 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            292 
_citation.language                  ? 
_citation.page_first                1141 
_citation.page_last                 1158 
_citation.title                     
'Molecular basis of human angiotensin-1 converting enzyme inhibition by a series of diprolyl-derived compounds.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1111/febs.17384 
_citation.pdbx_database_id_PubMed   39763019 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Gregory, K.S.'  1 ? 
primary 'Cozier, G.E.'   2 ? 
primary 'Fienberg, S.'   3 ? 
primary 'Chibale, K.'    4 ? 
primary 'Sturrock, E.D.' 5 ? 
primary 'Acharya, K.R.'  6 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1  polymer     man 'Angiotensin-converting enzyme' 68861.875 1   3.2.1.-,3.4.15.1 ? ? ? 
2  branched    man 
;beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose
;
732.682   1   ?                ? ? ? 
3  non-polymer syn 'ZINC ION' 65.409    1   ?                ? ? ? 
4  non-polymer syn 'DI(HYDROXYETHYL)ETHER' 106.120   1   ?                ? ? ? 
5  non-polymer syn 1,2-ETHANEDIOL 62.068    1   ?                ? ? ? 
6  non-polymer syn 'BORIC ACID' 61.833    1   ?                ? ? ? 
7  non-polymer syn 'CHLORIDE ION' 35.453    2   ?                ? ? ? 
8  non-polymer syn 
;(2S)-1-[(2S)-2-[[(1S)-1-[(2S)-1-(4-aminophenyl)carbonylpyrrolidin-2-yl]-2-oxidanyl-2-oxidanylidene-ethyl]amino]propanoyl]pyrrolidine-2-carboxylic acid
;
432.470   1   ?                ? ? ? 
9  non-polymer syn 2-acetamido-2-deoxy-beta-D-glucopyranose 221.208   1   ?                ? ? ? 
10 water       nat water 18.015    321 ?                ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'ACE,Dipeptidyl carboxypeptidase I,Kininase II' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;LVTDEAEASKFVEEYDRTSQVVWNEYAGANWNYNTNITTETSKILLQKNMQIAQHTLKYGTQARKFDVNQLQNTTIKRII
KKVQDLERAALPAQELEEYNKILLDMETTYSVATVCHPQGSCLQLEPDLTNVMATSRKYEDLLWAWEGWRDKAGRAILQF
YPKYVELINQAARLNGYVDAGDSWRSMYETPSLEQDLERLFQELQPLYLNLHAYVRRALHRHYGAQHINLEGPIPAHLLG
NMWAQTWSNIYDLVVPFPSAPSMDTTEAMLKQGWTPRRMFKEADDFFTSLGLLPVPPEFWQKSMLEKPTDGREVVCHASA
WDFYNGKDFRIKQCTTVNLEDLVVAHHEMGHIQYFMQYKDLPVALREGANPGFHEAIGDVLALSVSTPKHLHSLNLLSSE
GGSDEHDINFLMKMALDKIAFIPFSYLVDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRTQGDFDPGAKFHIPS
SVPYIRYFVSFIIQFQFHEALCQAAGHTGPLHKCDIYQSKEAGQRLATAMKLGFSRPWPEAMQLITGQPQMSASAMLSYF
KPLLDWLRTENELHGEKLGWPQYNWTPNSARSEGPLP
;
_entity_poly.pdbx_seq_one_letter_code_can   
;LVTDEAEASKFVEEYDRTSQVVWNEYAGANWNYNTNITTETSKILLQKNMQIAQHTLKYGTQARKFDVNQLQNTTIKRII
KKVQDLERAALPAQELEEYNKILLDMETTYSVATVCHPQGSCLQLEPDLTNVMATSRKYEDLLWAWEGWRDKAGRAILQF
YPKYVELINQAARLNGYVDAGDSWRSMYETPSLEQDLERLFQELQPLYLNLHAYVRRALHRHYGAQHINLEGPIPAHLLG
NMWAQTWSNIYDLVVPFPSAPSMDTTEAMLKQGWTPRRMFKEADDFFTSLGLLPVPPEFWQKSMLEKPTDGREVVCHASA
WDFYNGKDFRIKQCTTVNLEDLVVAHHEMGHIQYFMQYKDLPVALREGANPGFHEAIGDVLALSVSTPKHLHSLNLLSSE
GGSDEHDINFLMKMALDKIAFIPFSYLVDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRTQGDFDPGAKFHIPS
SVPYIRYFVSFIIQFQFHEALCQAAGHTGPLHKCDIYQSKEAGQRLATAMKLGFSRPWPEAMQLITGQPQMSASAMLSYF
KPLLDWLRTENELHGEKLGWPQYNWTPNSARSEGPLP
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
3  'ZINC ION' ZN    
4  'DI(HYDROXYETHYL)ETHER' PEG   
5  1,2-ETHANEDIOL EDO   
6  'BORIC ACID' BO3   
7  'CHLORIDE ION' CL    
8  
;(2S)-1-[(2S)-2-[[(1S)-1-[(2S)-1-(4-aminophenyl)carbonylpyrrolidin-2-yl]-2-oxidanyl-2-oxidanylidene-ethyl]amino]propanoyl]pyrrolidine-2-carboxylic acid
;
A1IJW 
9  2-acetamido-2-deoxy-beta-D-glucopyranose NAG   
10 water HOH   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   LEU n 
1 2   VAL n 
1 3   THR n 
1 4   ASP n 
1 5   GLU n 
1 6   ALA n 
1 7   GLU n 
1 8   ALA n 
1 9   SER n 
1 10  LYS n 
1 11  PHE n 
1 12  VAL n 
1 13  GLU n 
1 14  GLU n 
1 15  TYR n 
1 16  ASP n 
1 17  ARG n 
1 18  THR n 
1 19  SER n 
1 20  GLN n 
1 21  VAL n 
1 22  VAL n 
1 23  TRP n 
1 24  ASN n 
1 25  GLU n 
1 26  TYR n 
1 27  ALA n 
1 28  GLY n 
1 29  ALA n 
1 30  ASN n 
1 31  TRP n 
1 32  ASN n 
1 33  TYR n 
1 34  ASN n 
1 35  THR n 
1 36  ASN n 
1 37  ILE n 
1 38  THR n 
1 39  THR n 
1 40  GLU n 
1 41  THR n 
1 42  SER n 
1 43  LYS n 
1 44  ILE n 
1 45  LEU n 
1 46  LEU n 
1 47  GLN n 
1 48  LYS n 
1 49  ASN n 
1 50  MET n 
1 51  GLN n 
1 52  ILE n 
1 53  ALA n 
1 54  GLN n 
1 55  HIS n 
1 56  THR n 
1 57  LEU n 
1 58  LYS n 
1 59  TYR n 
1 60  GLY n 
1 61  THR n 
1 62  GLN n 
1 63  ALA n 
1 64  ARG n 
1 65  LYS n 
1 66  PHE n 
1 67  ASP n 
1 68  VAL n 
1 69  ASN n 
1 70  GLN n 
1 71  LEU n 
1 72  GLN n 
1 73  ASN n 
1 74  THR n 
1 75  THR n 
1 76  ILE n 
1 77  LYS n 
1 78  ARG n 
1 79  ILE n 
1 80  ILE n 
1 81  LYS n 
1 82  LYS n 
1 83  VAL n 
1 84  GLN n 
1 85  ASP n 
1 86  LEU n 
1 87  GLU n 
1 88  ARG n 
1 89  ALA n 
1 90  ALA n 
1 91  LEU n 
1 92  PRO n 
1 93  ALA n 
1 94  GLN n 
1 95  GLU n 
1 96  LEU n 
1 97  GLU n 
1 98  GLU n 
1 99  TYR n 
1 100 ASN n 
1 101 LYS n 
1 102 ILE n 
1 103 LEU n 
1 104 LEU n 
1 105 ASP n 
1 106 MET n 
1 107 GLU n 
1 108 THR n 
1 109 THR n 
1 110 TYR n 
1 111 SER n 
1 112 VAL n 
1 113 ALA n 
1 114 THR n 
1 115 VAL n 
1 116 CYS n 
1 117 HIS n 
1 118 PRO n 
1 119 GLN n 
1 120 GLY n 
1 121 SER n 
1 122 CYS n 
1 123 LEU n 
1 124 GLN n 
1 125 LEU n 
1 126 GLU n 
1 127 PRO n 
1 128 ASP n 
1 129 LEU n 
1 130 THR n 
1 131 ASN n 
1 132 VAL n 
1 133 MET n 
1 134 ALA n 
1 135 THR n 
1 136 SER n 
1 137 ARG n 
1 138 LYS n 
1 139 TYR n 
1 140 GLU n 
1 141 ASP n 
1 142 LEU n 
1 143 LEU n 
1 144 TRP n 
1 145 ALA n 
1 146 TRP n 
1 147 GLU n 
1 148 GLY n 
1 149 TRP n 
1 150 ARG n 
1 151 ASP n 
1 152 LYS n 
1 153 ALA n 
1 154 GLY n 
1 155 ARG n 
1 156 ALA n 
1 157 ILE n 
1 158 LEU n 
1 159 GLN n 
1 160 PHE n 
1 161 TYR n 
1 162 PRO n 
1 163 LYS n 
1 164 TYR n 
1 165 VAL n 
1 166 GLU n 
1 167 LEU n 
1 168 ILE n 
1 169 ASN n 
1 170 GLN n 
1 171 ALA n 
1 172 ALA n 
1 173 ARG n 
1 174 LEU n 
1 175 ASN n 
1 176 GLY n 
1 177 TYR n 
1 178 VAL n 
1 179 ASP n 
1 180 ALA n 
1 181 GLY n 
1 182 ASP n 
1 183 SER n 
1 184 TRP n 
1 185 ARG n 
1 186 SER n 
1 187 MET n 
1 188 TYR n 
1 189 GLU n 
1 190 THR n 
1 191 PRO n 
1 192 SER n 
1 193 LEU n 
1 194 GLU n 
1 195 GLN n 
1 196 ASP n 
1 197 LEU n 
1 198 GLU n 
1 199 ARG n 
1 200 LEU n 
1 201 PHE n 
1 202 GLN n 
1 203 GLU n 
1 204 LEU n 
1 205 GLN n 
1 206 PRO n 
1 207 LEU n 
1 208 TYR n 
1 209 LEU n 
1 210 ASN n 
1 211 LEU n 
1 212 HIS n 
1 213 ALA n 
1 214 TYR n 
1 215 VAL n 
1 216 ARG n 
1 217 ARG n 
1 218 ALA n 
1 219 LEU n 
1 220 HIS n 
1 221 ARG n 
1 222 HIS n 
1 223 TYR n 
1 224 GLY n 
1 225 ALA n 
1 226 GLN n 
1 227 HIS n 
1 228 ILE n 
1 229 ASN n 
1 230 LEU n 
1 231 GLU n 
1 232 GLY n 
1 233 PRO n 
1 234 ILE n 
1 235 PRO n 
1 236 ALA n 
1 237 HIS n 
1 238 LEU n 
1 239 LEU n 
1 240 GLY n 
1 241 ASN n 
1 242 MET n 
1 243 TRP n 
1 244 ALA n 
1 245 GLN n 
1 246 THR n 
1 247 TRP n 
1 248 SER n 
1 249 ASN n 
1 250 ILE n 
1 251 TYR n 
1 252 ASP n 
1 253 LEU n 
1 254 VAL n 
1 255 VAL n 
1 256 PRO n 
1 257 PHE n 
1 258 PRO n 
1 259 SER n 
1 260 ALA n 
1 261 PRO n 
1 262 SER n 
1 263 MET n 
1 264 ASP n 
1 265 THR n 
1 266 THR n 
1 267 GLU n 
1 268 ALA n 
1 269 MET n 
1 270 LEU n 
1 271 LYS n 
1 272 GLN n 
1 273 GLY n 
1 274 TRP n 
1 275 THR n 
1 276 PRO n 
1 277 ARG n 
1 278 ARG n 
1 279 MET n 
1 280 PHE n 
1 281 LYS n 
1 282 GLU n 
1 283 ALA n 
1 284 ASP n 
1 285 ASP n 
1 286 PHE n 
1 287 PHE n 
1 288 THR n 
1 289 SER n 
1 290 LEU n 
1 291 GLY n 
1 292 LEU n 
1 293 LEU n 
1 294 PRO n 
1 295 VAL n 
1 296 PRO n 
1 297 PRO n 
1 298 GLU n 
1 299 PHE n 
1 300 TRP n 
1 301 GLN n 
1 302 LYS n 
1 303 SER n 
1 304 MET n 
1 305 LEU n 
1 306 GLU n 
1 307 LYS n 
1 308 PRO n 
1 309 THR n 
1 310 ASP n 
1 311 GLY n 
1 312 ARG n 
1 313 GLU n 
1 314 VAL n 
1 315 VAL n 
1 316 CYS n 
1 317 HIS n 
1 318 ALA n 
1 319 SER n 
1 320 ALA n 
1 321 TRP n 
1 322 ASP n 
1 323 PHE n 
1 324 TYR n 
1 325 ASN n 
1 326 GLY n 
1 327 LYS n 
1 328 ASP n 
1 329 PHE n 
1 330 ARG n 
1 331 ILE n 
1 332 LYS n 
1 333 GLN n 
1 334 CYS n 
1 335 THR n 
1 336 THR n 
1 337 VAL n 
1 338 ASN n 
1 339 LEU n 
1 340 GLU n 
1 341 ASP n 
1 342 LEU n 
1 343 VAL n 
1 344 VAL n 
1 345 ALA n 
1 346 HIS n 
1 347 HIS n 
1 348 GLU n 
1 349 MET n 
1 350 GLY n 
1 351 HIS n 
1 352 ILE n 
1 353 GLN n 
1 354 TYR n 
1 355 PHE n 
1 356 MET n 
1 357 GLN n 
1 358 TYR n 
1 359 LYS n 
1 360 ASP n 
1 361 LEU n 
1 362 PRO n 
1 363 VAL n 
1 364 ALA n 
1 365 LEU n 
1 366 ARG n 
1 367 GLU n 
1 368 GLY n 
1 369 ALA n 
1 370 ASN n 
1 371 PRO n 
1 372 GLY n 
1 373 PHE n 
1 374 HIS n 
1 375 GLU n 
1 376 ALA n 
1 377 ILE n 
1 378 GLY n 
1 379 ASP n 
1 380 VAL n 
1 381 LEU n 
1 382 ALA n 
1 383 LEU n 
1 384 SER n 
1 385 VAL n 
1 386 SER n 
1 387 THR n 
1 388 PRO n 
1 389 LYS n 
1 390 HIS n 
1 391 LEU n 
1 392 HIS n 
1 393 SER n 
1 394 LEU n 
1 395 ASN n 
1 396 LEU n 
1 397 LEU n 
1 398 SER n 
1 399 SER n 
1 400 GLU n 
1 401 GLY n 
1 402 GLY n 
1 403 SER n 
1 404 ASP n 
1 405 GLU n 
1 406 HIS n 
1 407 ASP n 
1 408 ILE n 
1 409 ASN n 
1 410 PHE n 
1 411 LEU n 
1 412 MET n 
1 413 LYS n 
1 414 MET n 
1 415 ALA n 
1 416 LEU n 
1 417 ASP n 
1 418 LYS n 
1 419 ILE n 
1 420 ALA n 
1 421 PHE n 
1 422 ILE n 
1 423 PRO n 
1 424 PHE n 
1 425 SER n 
1 426 TYR n 
1 427 LEU n 
1 428 VAL n 
1 429 ASP n 
1 430 GLN n 
1 431 TRP n 
1 432 ARG n 
1 433 TRP n 
1 434 ARG n 
1 435 VAL n 
1 436 PHE n 
1 437 ASP n 
1 438 GLY n 
1 439 SER n 
1 440 ILE n 
1 441 THR n 
1 442 LYS n 
1 443 GLU n 
1 444 ASN n 
1 445 TYR n 
1 446 ASN n 
1 447 GLN n 
1 448 GLU n 
1 449 TRP n 
1 450 TRP n 
1 451 SER n 
1 452 LEU n 
1 453 ARG n 
1 454 LEU n 
1 455 LYS n 
1 456 TYR n 
1 457 GLN n 
1 458 GLY n 
1 459 LEU n 
1 460 CYS n 
1 461 PRO n 
1 462 PRO n 
1 463 VAL n 
1 464 PRO n 
1 465 ARG n 
1 466 THR n 
1 467 GLN n 
1 468 GLY n 
1 469 ASP n 
1 470 PHE n 
1 471 ASP n 
1 472 PRO n 
1 473 GLY n 
1 474 ALA n 
1 475 LYS n 
1 476 PHE n 
1 477 HIS n 
1 478 ILE n 
1 479 PRO n 
1 480 SER n 
1 481 SER n 
1 482 VAL n 
1 483 PRO n 
1 484 TYR n 
1 485 ILE n 
1 486 ARG n 
1 487 TYR n 
1 488 PHE n 
1 489 VAL n 
1 490 SER n 
1 491 PHE n 
1 492 ILE n 
1 493 ILE n 
1 494 GLN n 
1 495 PHE n 
1 496 GLN n 
1 497 PHE n 
1 498 HIS n 
1 499 GLU n 
1 500 ALA n 
1 501 LEU n 
1 502 CYS n 
1 503 GLN n 
1 504 ALA n 
1 505 ALA n 
1 506 GLY n 
1 507 HIS n 
1 508 THR n 
1 509 GLY n 
1 510 PRO n 
1 511 LEU n 
1 512 HIS n 
1 513 LYS n 
1 514 CYS n 
1 515 ASP n 
1 516 ILE n 
1 517 TYR n 
1 518 GLN n 
1 519 SER n 
1 520 LYS n 
1 521 GLU n 
1 522 ALA n 
1 523 GLY n 
1 524 GLN n 
1 525 ARG n 
1 526 LEU n 
1 527 ALA n 
1 528 THR n 
1 529 ALA n 
1 530 MET n 
1 531 LYS n 
1 532 LEU n 
1 533 GLY n 
1 534 PHE n 
1 535 SER n 
1 536 ARG n 
1 537 PRO n 
1 538 TRP n 
1 539 PRO n 
1 540 GLU n 
1 541 ALA n 
1 542 MET n 
1 543 GLN n 
1 544 LEU n 
1 545 ILE n 
1 546 THR n 
1 547 GLY n 
1 548 GLN n 
1 549 PRO n 
1 550 GLN n 
1 551 MET n 
1 552 SER n 
1 553 ALA n 
1 554 SER n 
1 555 ALA n 
1 556 MET n 
1 557 LEU n 
1 558 SER n 
1 559 TYR n 
1 560 PHE n 
1 561 LYS n 
1 562 PRO n 
1 563 LEU n 
1 564 LEU n 
1 565 ASP n 
1 566 TRP n 
1 567 LEU n 
1 568 ARG n 
1 569 THR n 
1 570 GLU n 
1 571 ASN n 
1 572 GLU n 
1 573 LEU n 
1 574 HIS n 
1 575 GLY n 
1 576 GLU n 
1 577 LYS n 
1 578 LEU n 
1 579 GLY n 
1 580 TRP n 
1 581 PRO n 
1 582 GLN n 
1 583 TYR n 
1 584 ASN n 
1 585 TRP n 
1 586 THR n 
1 587 PRO n 
1 588 ASN n 
1 589 SER n 
1 590 ALA n 
1 591 ARG n 
1 592 SER n 
1 593 GLU n 
1 594 GLY n 
1 595 PRO n 
1 596 LEU n 
1 597 PRO n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   597 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'ACE, DCP, DCP1' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Cricetulus griseus' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     10029 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
_pdbx_entity_branch.entity_id   2 
_pdbx_entity_branch.type        oligosaccharide 
# 
loop_
_pdbx_entity_branch_descriptor.ordinal 
_pdbx_entity_branch_descriptor.entity_id 
_pdbx_entity_branch_descriptor.descriptor 
_pdbx_entity_branch_descriptor.type 
_pdbx_entity_branch_descriptor.program 
_pdbx_entity_branch_descriptor.program_version 
1 2 'DManpb1-4DGlcpNAcb1-4[LFucpa1-6]DGlcpNAcb1-ROH'                                                    
'Glycam Condensed Sequence' GMML       1.0   
2 2 'WURCS=2.0/3,4,3/[a2122h-1b_1-5_2*NCC/3=O][a1122h-1b_1-5][a1221m-1a_1-5]/1-1-2-3/a4-b1_a6-d1_b4-c1' WURCS PDB2Glycan 1.1.0 
3 2 '[][D-1-deoxy-GlcpNAc]{[(4+1)][b-D-GlcpNAc]{[(4+1)][b-D-Manp]{}}[(6+1)][a-L-Fucp]{}}'               LINUCS PDB-CARE   ?     
# 
loop_
_pdbx_entity_branch_link.link_id 
_pdbx_entity_branch_link.entity_id 
_pdbx_entity_branch_link.entity_branch_list_num_1 
_pdbx_entity_branch_link.comp_id_1 
_pdbx_entity_branch_link.atom_id_1 
_pdbx_entity_branch_link.leaving_atom_id_1 
_pdbx_entity_branch_link.entity_branch_list_num_2 
_pdbx_entity_branch_link.comp_id_2 
_pdbx_entity_branch_link.atom_id_2 
_pdbx_entity_branch_link.leaving_atom_id_2 
_pdbx_entity_branch_link.value_order 
_pdbx_entity_branch_link.details 
1 2 2 NAG C1 O1 1 NAG O4 HO4 sing ? 
2 2 3 BMA C1 O1 2 NAG O4 HO4 sing ? 
3 2 4 FUC C1 O1 1 NAG O6 HO6 sing ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1IJW non-polymer                   . 
;(2S)-1-[(2S)-2-[[(1S)-1-[(2S)-1-(4-aminophenyl)carbonylpyrrolidin-2-yl]-2-oxidanyl-2-oxidanylidene-ethyl]amino]propanoyl]pyrrolidine-2-carboxylic acid
;
? 'C21 H28 N4 O6'  432.470 
ALA   'L-peptide linking'           y ALANINE ? 'C3 H7 N O2'     89.093  
ARG   'L-peptide linking'           y ARGININE ? 'C6 H15 N4 O2 1' 175.209 
ASN   'L-peptide linking'           y ASPARAGINE ? 'C4 H8 N2 O3'    132.118 
ASP   'L-peptide linking'           y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
BMA   'D-saccharide, beta linking'  . beta-D-mannopyranose 'beta-D-mannose; D-mannose; mannose' 'C6 H12 O6'      180.156 
BO3   non-polymer                   . 'BORIC ACID' ? 'B H3 O3'        61.833  
CL    non-polymer                   . 'CHLORIDE ION' ? 'Cl -1'          35.453  
CYS   'L-peptide linking'           y CYSTEINE ? 'C3 H7 N O2 S'   121.158 
EDO   non-polymer                   . 1,2-ETHANEDIOL 'ETHYLENE GLYCOL' 'C2 H6 O2'       62.068  
FUC   'L-saccharide, alpha linking' . alpha-L-fucopyranose 'alpha-L-fucose; 6-deoxy-alpha-L-galactopyranose; L-fucose; fucose' 
'C6 H12 O5'      164.156 
GLN   'L-peptide linking'           y GLUTAMINE ? 'C5 H10 N2 O3'   146.144 
GLU   'L-peptide linking'           y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY   'peptide linking'             y GLYCINE ? 'C2 H5 N O2'     75.067  
HIS   'L-peptide linking'           y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 
HOH   non-polymer                   . WATER ? 'H2 O'           18.015  
ILE   'L-peptide linking'           y ISOLEUCINE ? 'C6 H13 N O2'    131.173 
LEU   'L-peptide linking'           y LEUCINE ? 'C6 H13 N O2'    131.173 
LYS   'L-peptide linking'           y LYSINE ? 'C6 H15 N2 O2 1' 147.195 
MET   'L-peptide linking'           y METHIONINE ? 'C5 H11 N O2 S'  149.211 
NAG   'D-saccharide, beta linking'  . 2-acetamido-2-deoxy-beta-D-glucopyranose 
;N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE
;
'C8 H15 N O6'    221.208 
PEG   non-polymer                   . 'DI(HYDROXYETHYL)ETHER' ? 'C4 H10 O3'      106.120 
PHE   'L-peptide linking'           y PHENYLALANINE ? 'C9 H11 N O2'    165.189 
PRO   'L-peptide linking'           y PROLINE ? 'C5 H9 N O2'     115.130 
SER   'L-peptide linking'           y SERINE ? 'C3 H7 N O3'     105.093 
THR   'L-peptide linking'           y THREONINE ? 'C4 H9 N O3'     119.119 
TRP   'L-peptide linking'           y TRYPTOPHAN ? 'C11 H12 N2 O2'  204.225 
TYR   'L-peptide linking'           y TYROSINE ? 'C9 H11 N O3'    181.189 
VAL   'L-peptide linking'           y VALINE ? 'C5 H11 N O2'    117.146 
ZN    non-polymer                   . 'ZINC ION' ? 'Zn 2'           65.409  
# 
loop_
_pdbx_chem_comp_identifier.comp_id 
_pdbx_chem_comp_identifier.type 
_pdbx_chem_comp_identifier.program 
_pdbx_chem_comp_identifier.program_version 
_pdbx_chem_comp_identifier.identifier 
BMA 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DManpb                         
BMA 'COMMON NAME'                         GMML     1.0 b-D-mannopyranose              
BMA 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 b-D-Manp                       
BMA 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 Man                            
FUC 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 LFucpa                         
FUC 'COMMON NAME'                         GMML     1.0 a-L-fucopyranose               
FUC 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 a-L-Fucp                       
FUC 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 Fuc                            
NAG 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DGlcpNAcb                      
NAG 'COMMON NAME'                         GMML     1.0 N-acetyl-b-D-glucopyranosamine 
NAG 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 b-D-GlcpNAc                    
NAG 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 GlcNAc                         
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   LEU 1   37  ?   ?   ?   A . n 
A 1 2   VAL 2   38  ?   ?   ?   A . n 
A 1 3   THR 3   39  ?   ?   ?   A . n 
A 1 4   ASP 4   40  ?   ?   ?   A . n 
A 1 5   GLU 5   41  41  GLU GLU A . n 
A 1 6   ALA 6   42  42  ALA ALA A . n 
A 1 7   GLU 7   43  43  GLU GLU A . n 
A 1 8   ALA 8   44  44  ALA ALA A . n 
A 1 9   SER 9   45  45  SER SER A . n 
A 1 10  LYS 10  46  46  LYS LYS A . n 
A 1 11  PHE 11  47  47  PHE PHE A . n 
A 1 12  VAL 12  48  48  VAL VAL A . n 
A 1 13  GLU 13  49  49  GLU GLU A . n 
A 1 14  GLU 14  50  50  GLU GLU A . n 
A 1 15  TYR 15  51  51  TYR TYR A . n 
A 1 16  ASP 16  52  52  ASP ASP A . n 
A 1 17  ARG 17  53  53  ARG ARG A . n 
A 1 18  THR 18  54  54  THR THR A . n 
A 1 19  SER 19  55  55  SER SER A . n 
A 1 20  GLN 20  56  56  GLN GLN A . n 
A 1 21  VAL 21  57  57  VAL VAL A . n 
A 1 22  VAL 22  58  58  VAL VAL A . n 
A 1 23  TRP 23  59  59  TRP TRP A . n 
A 1 24  ASN 24  60  60  ASN ASN A . n 
A 1 25  GLU 25  61  61  GLU GLU A . n 
A 1 26  TYR 26  62  62  TYR TYR A . n 
A 1 27  ALA 27  63  63  ALA ALA A . n 
A 1 28  GLY 28  64  64  GLY GLY A . n 
A 1 29  ALA 29  65  65  ALA ALA A . n 
A 1 30  ASN 30  66  66  ASN ASN A . n 
A 1 31  TRP 31  67  67  TRP TRP A . n 
A 1 32  ASN 32  68  68  ASN ASN A . n 
A 1 33  TYR 33  69  69  TYR TYR A . n 
A 1 34  ASN 34  70  70  ASN ASN A . n 
A 1 35  THR 35  71  71  THR THR A . n 
A 1 36  ASN 36  72  72  ASN ASN A . n 
A 1 37  ILE 37  73  73  ILE ILE A . n 
A 1 38  THR 38  74  74  THR THR A . n 
A 1 39  THR 39  75  75  THR THR A . n 
A 1 40  GLU 40  76  76  GLU GLU A . n 
A 1 41  THR 41  77  77  THR THR A . n 
A 1 42  SER 42  78  78  SER SER A . n 
A 1 43  LYS 43  79  79  LYS LYS A . n 
A 1 44  ILE 44  80  80  ILE ILE A . n 
A 1 45  LEU 45  81  81  LEU LEU A . n 
A 1 46  LEU 46  82  82  LEU LEU A . n 
A 1 47  GLN 47  83  83  GLN GLN A . n 
A 1 48  LYS 48  84  84  LYS LYS A . n 
A 1 49  ASN 49  85  85  ASN ASN A . n 
A 1 50  MET 50  86  86  MET MET A . n 
A 1 51  GLN 51  87  87  GLN GLN A . n 
A 1 52  ILE 52  88  88  ILE ILE A . n 
A 1 53  ALA 53  89  89  ALA ALA A . n 
A 1 54  GLN 54  90  90  GLN GLN A . n 
A 1 55  HIS 55  91  91  HIS HIS A . n 
A 1 56  THR 56  92  92  THR THR A . n 
A 1 57  LEU 57  93  93  LEU LEU A . n 
A 1 58  LYS 58  94  94  LYS LYS A . n 
A 1 59  TYR 59  95  95  TYR TYR A . n 
A 1 60  GLY 60  96  96  GLY GLY A . n 
A 1 61  THR 61  97  97  THR THR A . n 
A 1 62  GLN 62  98  98  GLN GLN A . n 
A 1 63  ALA 63  99  99  ALA ALA A . n 
A 1 64  ARG 64  100 100 ARG ARG A . n 
A 1 65  LYS 65  101 101 LYS LYS A . n 
A 1 66  PHE 66  102 102 PHE PHE A . n 
A 1 67  ASP 67  103 103 ASP ASP A . n 
A 1 68  VAL 68  104 104 VAL VAL A . n 
A 1 69  ASN 69  105 105 ASN ASN A . n 
A 1 70  GLN 70  106 106 GLN GLN A . n 
A 1 71  LEU 71  107 107 LEU LEU A . n 
A 1 72  GLN 72  108 108 GLN GLN A . n 
A 1 73  ASN 73  109 109 ASN ASN A . n 
A 1 74  THR 74  110 110 THR THR A . n 
A 1 75  THR 75  111 111 THR THR A . n 
A 1 76  ILE 76  112 112 ILE ILE A . n 
A 1 77  LYS 77  113 113 LYS LYS A . n 
A 1 78  ARG 78  114 114 ARG ARG A . n 
A 1 79  ILE 79  115 115 ILE ILE A . n 
A 1 80  ILE 80  116 116 ILE ILE A . n 
A 1 81  LYS 81  117 117 LYS LYS A . n 
A 1 82  LYS 82  118 118 LYS LYS A . n 
A 1 83  VAL 83  119 119 VAL VAL A . n 
A 1 84  GLN 84  120 120 GLN GLN A . n 
A 1 85  ASP 85  121 121 ASP ASP A . n 
A 1 86  LEU 86  122 122 LEU LEU A . n 
A 1 87  GLU 87  123 123 GLU GLU A . n 
A 1 88  ARG 88  124 124 ARG ARG A . n 
A 1 89  ALA 89  125 125 ALA ALA A . n 
A 1 90  ALA 90  126 126 ALA ALA A . n 
A 1 91  LEU 91  127 127 LEU LEU A . n 
A 1 92  PRO 92  128 128 PRO PRO A . n 
A 1 93  ALA 93  129 129 ALA ALA A . n 
A 1 94  GLN 94  130 130 GLN GLN A . n 
A 1 95  GLU 95  131 131 GLU GLU A . n 
A 1 96  LEU 96  132 132 LEU LEU A . n 
A 1 97  GLU 97  133 133 GLU GLU A . n 
A 1 98  GLU 98  134 134 GLU GLU A . n 
A 1 99  TYR 99  135 135 TYR TYR A . n 
A 1 100 ASN 100 136 136 ASN ASN A . n 
A 1 101 LYS 101 137 137 LYS LYS A . n 
A 1 102 ILE 102 138 138 ILE ILE A . n 
A 1 103 LEU 103 139 139 LEU LEU A . n 
A 1 104 LEU 104 140 140 LEU LEU A . n 
A 1 105 ASP 105 141 141 ASP ASP A . n 
A 1 106 MET 106 142 142 MET MET A . n 
A 1 107 GLU 107 143 143 GLU GLU A . n 
A 1 108 THR 108 144 144 THR THR A . n 
A 1 109 THR 109 145 145 THR THR A . n 
A 1 110 TYR 110 146 146 TYR TYR A . n 
A 1 111 SER 111 147 147 SER SER A . n 
A 1 112 VAL 112 148 148 VAL VAL A . n 
A 1 113 ALA 113 149 149 ALA ALA A . n 
A 1 114 THR 114 150 150 THR THR A . n 
A 1 115 VAL 115 151 151 VAL VAL A . n 
A 1 116 CYS 116 152 152 CYS CYS A . n 
A 1 117 HIS 117 153 153 HIS HIS A . n 
A 1 118 PRO 118 154 154 PRO PRO A . n 
A 1 119 GLN 119 155 ?   ?   ?   A . n 
A 1 120 GLY 120 156 156 GLY GLY A . n 
A 1 121 SER 121 157 157 SER SER A . n 
A 1 122 CYS 122 158 158 CYS CYS A . n 
A 1 123 LEU 123 159 159 LEU LEU A . n 
A 1 124 GLN 124 160 160 GLN GLN A . n 
A 1 125 LEU 125 161 161 LEU LEU A . n 
A 1 126 GLU 126 162 162 GLU GLU A . n 
A 1 127 PRO 127 163 163 PRO PRO A . n 
A 1 128 ASP 128 164 164 ASP ASP A . n 
A 1 129 LEU 129 165 165 LEU LEU A . n 
A 1 130 THR 130 166 166 THR THR A . n 
A 1 131 ASN 131 167 167 ASN ASN A . n 
A 1 132 VAL 132 168 168 VAL VAL A . n 
A 1 133 MET 133 169 169 MET MET A . n 
A 1 134 ALA 134 170 170 ALA ALA A . n 
A 1 135 THR 135 171 171 THR THR A . n 
A 1 136 SER 136 172 172 SER SER A . n 
A 1 137 ARG 137 173 173 ARG ARG A . n 
A 1 138 LYS 138 174 174 LYS LYS A . n 
A 1 139 TYR 139 175 175 TYR TYR A . n 
A 1 140 GLU 140 176 176 GLU GLU A . n 
A 1 141 ASP 141 177 177 ASP ASP A . n 
A 1 142 LEU 142 178 178 LEU LEU A . n 
A 1 143 LEU 143 179 179 LEU LEU A . n 
A 1 144 TRP 144 180 180 TRP TRP A . n 
A 1 145 ALA 145 181 181 ALA ALA A . n 
A 1 146 TRP 146 182 182 TRP TRP A . n 
A 1 147 GLU 147 183 183 GLU GLU A . n 
A 1 148 GLY 148 184 184 GLY GLY A . n 
A 1 149 TRP 149 185 185 TRP TRP A . n 
A 1 150 ARG 150 186 186 ARG ARG A . n 
A 1 151 ASP 151 187 187 ASP ASP A . n 
A 1 152 LYS 152 188 188 LYS LYS A . n 
A 1 153 ALA 153 189 189 ALA ALA A . n 
A 1 154 GLY 154 190 190 GLY GLY A . n 
A 1 155 ARG 155 191 191 ARG ARG A . n 
A 1 156 ALA 156 192 192 ALA ALA A . n 
A 1 157 ILE 157 193 193 ILE ILE A . n 
A 1 158 LEU 158 194 194 LEU LEU A . n 
A 1 159 GLN 159 195 195 GLN GLN A . n 
A 1 160 PHE 160 196 196 PHE PHE A . n 
A 1 161 TYR 161 197 197 TYR TYR A . n 
A 1 162 PRO 162 198 198 PRO PRO A . n 
A 1 163 LYS 163 199 199 LYS LYS A . n 
A 1 164 TYR 164 200 200 TYR TYR A . n 
A 1 165 VAL 165 201 201 VAL VAL A . n 
A 1 166 GLU 166 202 202 GLU GLU A . n 
A 1 167 LEU 167 203 203 LEU LEU A . n 
A 1 168 ILE 168 204 204 ILE ILE A . n 
A 1 169 ASN 169 205 205 ASN ASN A . n 
A 1 170 GLN 170 206 206 GLN GLN A . n 
A 1 171 ALA 171 207 207 ALA ALA A . n 
A 1 172 ALA 172 208 208 ALA ALA A . n 
A 1 173 ARG 173 209 209 ARG ARG A . n 
A 1 174 LEU 174 210 210 LEU LEU A . n 
A 1 175 ASN 175 211 211 ASN ASN A . n 
A 1 176 GLY 176 212 212 GLY GLY A . n 
A 1 177 TYR 177 213 213 TYR TYR A . n 
A 1 178 VAL 178 214 214 VAL VAL A . n 
A 1 179 ASP 179 215 215 ASP ASP A . n 
A 1 180 ALA 180 216 216 ALA ALA A . n 
A 1 181 GLY 181 217 217 GLY GLY A . n 
A 1 182 ASP 182 218 218 ASP ASP A . n 
A 1 183 SER 183 219 219 SER SER A . n 
A 1 184 TRP 184 220 220 TRP TRP A . n 
A 1 185 ARG 185 221 221 ARG ARG A . n 
A 1 186 SER 186 222 222 SER SER A . n 
A 1 187 MET 187 223 223 MET MET A . n 
A 1 188 TYR 188 224 224 TYR TYR A . n 
A 1 189 GLU 189 225 225 GLU GLU A . n 
A 1 190 THR 190 226 226 THR THR A . n 
A 1 191 PRO 191 227 227 PRO PRO A . n 
A 1 192 SER 192 228 228 SER SER A . n 
A 1 193 LEU 193 229 229 LEU LEU A . n 
A 1 194 GLU 194 230 230 GLU GLU A . n 
A 1 195 GLN 195 231 231 GLN GLN A . n 
A 1 196 ASP 196 232 232 ASP ASP A . n 
A 1 197 LEU 197 233 233 LEU LEU A . n 
A 1 198 GLU 198 234 234 GLU GLU A . n 
A 1 199 ARG 199 235 235 ARG ARG A . n 
A 1 200 LEU 200 236 236 LEU LEU A . n 
A 1 201 PHE 201 237 237 PHE PHE A . n 
A 1 202 GLN 202 238 238 GLN GLN A . n 
A 1 203 GLU 203 239 239 GLU GLU A . n 
A 1 204 LEU 204 240 240 LEU LEU A . n 
A 1 205 GLN 205 241 241 GLN GLN A . n 
A 1 206 PRO 206 242 242 PRO PRO A . n 
A 1 207 LEU 207 243 243 LEU LEU A . n 
A 1 208 TYR 208 244 244 TYR TYR A . n 
A 1 209 LEU 209 245 245 LEU LEU A . n 
A 1 210 ASN 210 246 246 ASN ASN A . n 
A 1 211 LEU 211 247 247 LEU LEU A . n 
A 1 212 HIS 212 248 248 HIS HIS A . n 
A 1 213 ALA 213 249 249 ALA ALA A . n 
A 1 214 TYR 214 250 250 TYR TYR A . n 
A 1 215 VAL 215 251 251 VAL VAL A . n 
A 1 216 ARG 216 252 252 ARG ARG A . n 
A 1 217 ARG 217 253 253 ARG ARG A . n 
A 1 218 ALA 218 254 254 ALA ALA A . n 
A 1 219 LEU 219 255 255 LEU LEU A . n 
A 1 220 HIS 220 256 256 HIS HIS A . n 
A 1 221 ARG 221 257 257 ARG ARG A . n 
A 1 222 HIS 222 258 258 HIS HIS A . n 
A 1 223 TYR 223 259 259 TYR TYR A . n 
A 1 224 GLY 224 260 260 GLY GLY A . n 
A 1 225 ALA 225 261 261 ALA ALA A . n 
A 1 226 GLN 226 262 262 GLN GLN A . n 
A 1 227 HIS 227 263 263 HIS HIS A . n 
A 1 228 ILE 228 264 264 ILE ILE A . n 
A 1 229 ASN 229 265 265 ASN ASN A . n 
A 1 230 LEU 230 266 266 LEU LEU A . n 
A 1 231 GLU 231 267 267 GLU GLU A . n 
A 1 232 GLY 232 268 268 GLY GLY A . n 
A 1 233 PRO 233 269 269 PRO PRO A . n 
A 1 234 ILE 234 270 270 ILE ILE A . n 
A 1 235 PRO 235 271 271 PRO PRO A . n 
A 1 236 ALA 236 272 272 ALA ALA A . n 
A 1 237 HIS 237 273 273 HIS HIS A . n 
A 1 238 LEU 238 274 274 LEU LEU A . n 
A 1 239 LEU 239 275 275 LEU LEU A . n 
A 1 240 GLY 240 276 276 GLY GLY A . n 
A 1 241 ASN 241 277 277 ASN ASN A . n 
A 1 242 MET 242 278 278 MET MET A . n 
A 1 243 TRP 243 279 279 TRP TRP A . n 
A 1 244 ALA 244 280 280 ALA ALA A . n 
A 1 245 GLN 245 281 281 GLN GLN A . n 
A 1 246 THR 246 282 282 THR THR A . n 
A 1 247 TRP 247 283 283 TRP TRP A . n 
A 1 248 SER 248 284 284 SER SER A . n 
A 1 249 ASN 249 285 285 ASN ASN A . n 
A 1 250 ILE 250 286 286 ILE ILE A . n 
A 1 251 TYR 251 287 287 TYR TYR A . n 
A 1 252 ASP 252 288 288 ASP ASP A . n 
A 1 253 LEU 253 289 289 LEU LEU A . n 
A 1 254 VAL 254 290 290 VAL VAL A . n 
A 1 255 VAL 255 291 291 VAL VAL A . n 
A 1 256 PRO 256 292 292 PRO PRO A . n 
A 1 257 PHE 257 293 293 PHE PHE A . n 
A 1 258 PRO 258 294 294 PRO PRO A . n 
A 1 259 SER 259 295 295 SER SER A . n 
A 1 260 ALA 260 296 296 ALA ALA A . n 
A 1 261 PRO 261 297 297 PRO PRO A . n 
A 1 262 SER 262 298 298 SER SER A . n 
A 1 263 MET 263 299 299 MET MET A . n 
A 1 264 ASP 264 300 300 ASP ASP A . n 
A 1 265 THR 265 301 301 THR THR A . n 
A 1 266 THR 266 302 302 THR THR A . n 
A 1 267 GLU 267 303 303 GLU GLU A . n 
A 1 268 ALA 268 304 304 ALA ALA A . n 
A 1 269 MET 269 305 305 MET MET A . n 
A 1 270 LEU 270 306 306 LEU LEU A . n 
A 1 271 LYS 271 307 307 LYS LYS A . n 
A 1 272 GLN 272 308 308 GLN GLN A . n 
A 1 273 GLY 273 309 309 GLY GLY A . n 
A 1 274 TRP 274 310 310 TRP TRP A . n 
A 1 275 THR 275 311 311 THR THR A . n 
A 1 276 PRO 276 312 312 PRO PRO A . n 
A 1 277 ARG 277 313 313 ARG ARG A . n 
A 1 278 ARG 278 314 314 ARG ARG A . n 
A 1 279 MET 279 315 315 MET MET A . n 
A 1 280 PHE 280 316 316 PHE PHE A . n 
A 1 281 LYS 281 317 317 LYS LYS A . n 
A 1 282 GLU 282 318 318 GLU GLU A . n 
A 1 283 ALA 283 319 319 ALA ALA A . n 
A 1 284 ASP 284 320 320 ASP ASP A . n 
A 1 285 ASP 285 321 321 ASP ASP A . n 
A 1 286 PHE 286 322 322 PHE PHE A . n 
A 1 287 PHE 287 323 323 PHE PHE A . n 
A 1 288 THR 288 324 324 THR THR A . n 
A 1 289 SER 289 325 325 SER SER A . n 
A 1 290 LEU 290 326 326 LEU LEU A . n 
A 1 291 GLY 291 327 327 GLY GLY A . n 
A 1 292 LEU 292 328 328 LEU LEU A . n 
A 1 293 LEU 293 329 329 LEU LEU A . n 
A 1 294 PRO 294 330 330 PRO PRO A . n 
A 1 295 VAL 295 331 331 VAL VAL A . n 
A 1 296 PRO 296 332 332 PRO PRO A . n 
A 1 297 PRO 297 333 333 PRO PRO A . n 
A 1 298 GLU 298 334 334 GLU GLU A . n 
A 1 299 PHE 299 335 335 PHE PHE A . n 
A 1 300 TRP 300 336 336 TRP TRP A . n 
A 1 301 GLN 301 337 337 GLN GLN A . n 
A 1 302 LYS 302 338 338 LYS LYS A . n 
A 1 303 SER 303 339 339 SER SER A . n 
A 1 304 MET 304 340 340 MET MET A . n 
A 1 305 LEU 305 341 341 LEU LEU A . n 
A 1 306 GLU 306 342 342 GLU GLU A . n 
A 1 307 LYS 307 343 343 LYS LYS A . n 
A 1 308 PRO 308 344 344 PRO PRO A . n 
A 1 309 THR 309 345 345 THR THR A . n 
A 1 310 ASP 310 346 346 ASP ASP A . n 
A 1 311 GLY 311 347 347 GLY GLY A . n 
A 1 312 ARG 312 348 348 ARG ARG A . n 
A 1 313 GLU 313 349 349 GLU GLU A . n 
A 1 314 VAL 314 350 350 VAL VAL A . n 
A 1 315 VAL 315 351 351 VAL VAL A . n 
A 1 316 CYS 316 352 352 CYS CYS A . n 
A 1 317 HIS 317 353 353 HIS HIS A . n 
A 1 318 ALA 318 354 354 ALA ALA A . n 
A 1 319 SER 319 355 355 SER SER A . n 
A 1 320 ALA 320 356 356 ALA ALA A . n 
A 1 321 TRP 321 357 357 TRP TRP A . n 
A 1 322 ASP 322 358 358 ASP ASP A . n 
A 1 323 PHE 323 359 359 PHE PHE A . n 
A 1 324 TYR 324 360 360 TYR TYR A . n 
A 1 325 ASN 325 361 361 ASN ASN A . n 
A 1 326 GLY 326 362 362 GLY GLY A . n 
A 1 327 LYS 327 363 363 LYS LYS A . n 
A 1 328 ASP 328 364 364 ASP ASP A . n 
A 1 329 PHE 329 365 365 PHE PHE A . n 
A 1 330 ARG 330 366 366 ARG ARG A . n 
A 1 331 ILE 331 367 367 ILE ILE A . n 
A 1 332 LYS 332 368 368 LYS LYS A . n 
A 1 333 GLN 333 369 369 GLN GLN A . n 
A 1 334 CYS 334 370 370 CYS CYS A . n 
A 1 335 THR 335 371 371 THR THR A . n 
A 1 336 THR 336 372 372 THR THR A . n 
A 1 337 VAL 337 373 373 VAL VAL A . n 
A 1 338 ASN 338 374 374 ASN ASN A . n 
A 1 339 LEU 339 375 375 LEU LEU A . n 
A 1 340 GLU 340 376 376 GLU GLU A . n 
A 1 341 ASP 341 377 377 ASP ASP A . n 
A 1 342 LEU 342 378 378 LEU LEU A . n 
A 1 343 VAL 343 379 379 VAL VAL A . n 
A 1 344 VAL 344 380 380 VAL VAL A . n 
A 1 345 ALA 345 381 381 ALA ALA A . n 
A 1 346 HIS 346 382 382 HIS HIS A . n 
A 1 347 HIS 347 383 383 HIS HIS A . n 
A 1 348 GLU 348 384 384 GLU GLU A . n 
A 1 349 MET 349 385 385 MET MET A . n 
A 1 350 GLY 350 386 386 GLY GLY A . n 
A 1 351 HIS 351 387 387 HIS HIS A . n 
A 1 352 ILE 352 388 388 ILE ILE A . n 
A 1 353 GLN 353 389 389 GLN GLN A . n 
A 1 354 TYR 354 390 390 TYR TYR A . n 
A 1 355 PHE 355 391 391 PHE PHE A . n 
A 1 356 MET 356 392 392 MET MET A . n 
A 1 357 GLN 357 393 393 GLN GLN A . n 
A 1 358 TYR 358 394 394 TYR TYR A . n 
A 1 359 LYS 359 395 395 LYS LYS A . n 
A 1 360 ASP 360 396 396 ASP ASP A . n 
A 1 361 LEU 361 397 397 LEU LEU A . n 
A 1 362 PRO 362 398 398 PRO PRO A . n 
A 1 363 VAL 363 399 399 VAL VAL A . n 
A 1 364 ALA 364 400 400 ALA ALA A . n 
A 1 365 LEU 365 401 401 LEU LEU A . n 
A 1 366 ARG 366 402 402 ARG ARG A . n 
A 1 367 GLU 367 403 403 GLU GLU A . n 
A 1 368 GLY 368 404 404 GLY GLY A . n 
A 1 369 ALA 369 405 405 ALA ALA A . n 
A 1 370 ASN 370 406 406 ASN ASN A . n 
A 1 371 PRO 371 407 407 PRO PRO A . n 
A 1 372 GLY 372 408 408 GLY GLY A . n 
A 1 373 PHE 373 409 409 PHE PHE A . n 
A 1 374 HIS 374 410 410 HIS HIS A . n 
A 1 375 GLU 375 411 411 GLU GLU A . n 
A 1 376 ALA 376 412 412 ALA ALA A . n 
A 1 377 ILE 377 413 413 ILE ILE A . n 
A 1 378 GLY 378 414 414 GLY GLY A . n 
A 1 379 ASP 379 415 415 ASP ASP A . n 
A 1 380 VAL 380 416 416 VAL VAL A . n 
A 1 381 LEU 381 417 417 LEU LEU A . n 
A 1 382 ALA 382 418 418 ALA ALA A . n 
A 1 383 LEU 383 419 419 LEU LEU A . n 
A 1 384 SER 384 420 420 SER SER A . n 
A 1 385 VAL 385 421 421 VAL VAL A . n 
A 1 386 SER 386 422 422 SER SER A . n 
A 1 387 THR 387 423 423 THR THR A . n 
A 1 388 PRO 388 424 424 PRO PRO A . n 
A 1 389 LYS 389 425 425 LYS LYS A . n 
A 1 390 HIS 390 426 426 HIS HIS A . n 
A 1 391 LEU 391 427 427 LEU LEU A . n 
A 1 392 HIS 392 428 428 HIS HIS A . n 
A 1 393 SER 393 429 429 SER SER A . n 
A 1 394 LEU 394 430 430 LEU LEU A . n 
A 1 395 ASN 395 431 431 ASN ASN A . n 
A 1 396 LEU 396 432 432 LEU LEU A . n 
A 1 397 LEU 397 433 433 LEU LEU A . n 
A 1 398 SER 398 434 434 SER SER A . n 
A 1 399 SER 399 435 ?   ?   ?   A . n 
A 1 400 GLU 400 436 ?   ?   ?   A . n 
A 1 401 GLY 401 437 ?   ?   ?   A . n 
A 1 402 GLY 402 438 ?   ?   ?   A . n 
A 1 403 SER 403 439 439 SER SER A . n 
A 1 404 ASP 404 440 440 ASP ASP A . n 
A 1 405 GLU 405 441 441 GLU GLU A . n 
A 1 406 HIS 406 442 442 HIS HIS A . n 
A 1 407 ASP 407 443 443 ASP ASP A . n 
A 1 408 ILE 408 444 444 ILE ILE A . n 
A 1 409 ASN 409 445 445 ASN ASN A . n 
A 1 410 PHE 410 446 446 PHE PHE A . n 
A 1 411 LEU 411 447 447 LEU LEU A . n 
A 1 412 MET 412 448 448 MET MET A . n 
A 1 413 LYS 413 449 449 LYS LYS A . n 
A 1 414 MET 414 450 450 MET MET A . n 
A 1 415 ALA 415 451 451 ALA ALA A . n 
A 1 416 LEU 416 452 452 LEU LEU A . n 
A 1 417 ASP 417 453 453 ASP ASP A . n 
A 1 418 LYS 418 454 454 LYS LYS A . n 
A 1 419 ILE 419 455 455 ILE ILE A . n 
A 1 420 ALA 420 456 456 ALA ALA A . n 
A 1 421 PHE 421 457 457 PHE PHE A . n 
A 1 422 ILE 422 458 458 ILE ILE A . n 
A 1 423 PRO 423 459 459 PRO PRO A . n 
A 1 424 PHE 424 460 460 PHE PHE A . n 
A 1 425 SER 425 461 461 SER SER A . n 
A 1 426 TYR 426 462 462 TYR TYR A . n 
A 1 427 LEU 427 463 463 LEU LEU A . n 
A 1 428 VAL 428 464 464 VAL VAL A . n 
A 1 429 ASP 429 465 465 ASP ASP A . n 
A 1 430 GLN 430 466 466 GLN GLN A . n 
A 1 431 TRP 431 467 467 TRP TRP A . n 
A 1 432 ARG 432 468 468 ARG ARG A . n 
A 1 433 TRP 433 469 469 TRP TRP A . n 
A 1 434 ARG 434 470 470 ARG ARG A . n 
A 1 435 VAL 435 471 471 VAL VAL A . n 
A 1 436 PHE 436 472 472 PHE PHE A . n 
A 1 437 ASP 437 473 473 ASP ASP A . n 
A 1 438 GLY 438 474 474 GLY GLY A . n 
A 1 439 SER 439 475 475 SER SER A . n 
A 1 440 ILE 440 476 476 ILE ILE A . n 
A 1 441 THR 441 477 477 THR THR A . n 
A 1 442 LYS 442 478 478 LYS LYS A . n 
A 1 443 GLU 443 479 479 GLU GLU A . n 
A 1 444 ASN 444 480 480 ASN ASN A . n 
A 1 445 TYR 445 481 481 TYR TYR A . n 
A 1 446 ASN 446 482 482 ASN ASN A . n 
A 1 447 GLN 447 483 483 GLN GLN A . n 
A 1 448 GLU 448 484 484 GLU GLU A . n 
A 1 449 TRP 449 485 485 TRP TRP A . n 
A 1 450 TRP 450 486 486 TRP TRP A . n 
A 1 451 SER 451 487 487 SER SER A . n 
A 1 452 LEU 452 488 488 LEU LEU A . n 
A 1 453 ARG 453 489 489 ARG ARG A . n 
A 1 454 LEU 454 490 490 LEU LEU A . n 
A 1 455 LYS 455 491 491 LYS LYS A . n 
A 1 456 TYR 456 492 492 TYR TYR A . n 
A 1 457 GLN 457 493 493 GLN GLN A . n 
A 1 458 GLY 458 494 494 GLY GLY A . n 
A 1 459 LEU 459 495 495 LEU LEU A . n 
A 1 460 CYS 460 496 496 CYS CYS A . n 
A 1 461 PRO 461 497 497 PRO PRO A . n 
A 1 462 PRO 462 498 498 PRO PRO A . n 
A 1 463 VAL 463 499 499 VAL VAL A . n 
A 1 464 PRO 464 500 500 PRO PRO A . n 
A 1 465 ARG 465 501 501 ARG ARG A . n 
A 1 466 THR 466 502 502 THR THR A . n 
A 1 467 GLN 467 503 503 GLN GLN A . n 
A 1 468 GLY 468 504 504 GLY GLY A . n 
A 1 469 ASP 469 505 505 ASP ASP A . n 
A 1 470 PHE 470 506 506 PHE PHE A . n 
A 1 471 ASP 471 507 507 ASP ASP A . n 
A 1 472 PRO 472 508 508 PRO PRO A . n 
A 1 473 GLY 473 509 509 GLY GLY A . n 
A 1 474 ALA 474 510 510 ALA ALA A . n 
A 1 475 LYS 475 511 511 LYS LYS A . n 
A 1 476 PHE 476 512 512 PHE PHE A . n 
A 1 477 HIS 477 513 513 HIS HIS A . n 
A 1 478 ILE 478 514 514 ILE ILE A . n 
A 1 479 PRO 479 515 515 PRO PRO A . n 
A 1 480 SER 480 516 516 SER SER A . n 
A 1 481 SER 481 517 517 SER SER A . n 
A 1 482 VAL 482 518 518 VAL VAL A . n 
A 1 483 PRO 483 519 519 PRO PRO A . n 
A 1 484 TYR 484 520 520 TYR TYR A . n 
A 1 485 ILE 485 521 521 ILE ILE A . n 
A 1 486 ARG 486 522 522 ARG ARG A . n 
A 1 487 TYR 487 523 523 TYR TYR A . n 
A 1 488 PHE 488 524 524 PHE PHE A . n 
A 1 489 VAL 489 525 525 VAL VAL A . n 
A 1 490 SER 490 526 526 SER SER A . n 
A 1 491 PHE 491 527 527 PHE PHE A . n 
A 1 492 ILE 492 528 528 ILE ILE A . n 
A 1 493 ILE 493 529 529 ILE ILE A . n 
A 1 494 GLN 494 530 530 GLN GLN A . n 
A 1 495 PHE 495 531 531 PHE PHE A . n 
A 1 496 GLN 496 532 532 GLN GLN A . n 
A 1 497 PHE 497 533 533 PHE PHE A . n 
A 1 498 HIS 498 534 534 HIS HIS A . n 
A 1 499 GLU 499 535 535 GLU GLU A . n 
A 1 500 ALA 500 536 536 ALA ALA A . n 
A 1 501 LEU 501 537 537 LEU LEU A . n 
A 1 502 CYS 502 538 538 CYS CYS A . n 
A 1 503 GLN 503 539 539 GLN GLN A . n 
A 1 504 ALA 504 540 540 ALA ALA A . n 
A 1 505 ALA 505 541 541 ALA ALA A . n 
A 1 506 GLY 506 542 542 GLY GLY A . n 
A 1 507 HIS 507 543 543 HIS HIS A . n 
A 1 508 THR 508 544 544 THR THR A . n 
A 1 509 GLY 509 545 545 GLY GLY A . n 
A 1 510 PRO 510 546 546 PRO PRO A . n 
A 1 511 LEU 511 547 547 LEU LEU A . n 
A 1 512 HIS 512 548 548 HIS HIS A . n 
A 1 513 LYS 513 549 549 LYS LYS A . n 
A 1 514 CYS 514 550 550 CYS CYS A . n 
A 1 515 ASP 515 551 551 ASP ASP A . n 
A 1 516 ILE 516 552 552 ILE ILE A . n 
A 1 517 TYR 517 553 553 TYR TYR A . n 
A 1 518 GLN 518 554 554 GLN GLN A . n 
A 1 519 SER 519 555 555 SER SER A . n 
A 1 520 LYS 520 556 556 LYS LYS A . n 
A 1 521 GLU 521 557 557 GLU GLU A . n 
A 1 522 ALA 522 558 558 ALA ALA A . n 
A 1 523 GLY 523 559 559 GLY GLY A . n 
A 1 524 GLN 524 560 560 GLN GLN A . n 
A 1 525 ARG 525 561 561 ARG ARG A . n 
A 1 526 LEU 526 562 562 LEU LEU A . n 
A 1 527 ALA 527 563 563 ALA ALA A . n 
A 1 528 THR 528 564 564 THR THR A . n 
A 1 529 ALA 529 565 565 ALA ALA A . n 
A 1 530 MET 530 566 566 MET MET A . n 
A 1 531 LYS 531 567 567 LYS LYS A . n 
A 1 532 LEU 532 568 568 LEU LEU A . n 
A 1 533 GLY 533 569 569 GLY GLY A . n 
A 1 534 PHE 534 570 570 PHE PHE A . n 
A 1 535 SER 535 571 571 SER SER A . n 
A 1 536 ARG 536 572 572 ARG ARG A . n 
A 1 537 PRO 537 573 573 PRO PRO A . n 
A 1 538 TRP 538 574 574 TRP TRP A . n 
A 1 539 PRO 539 575 575 PRO PRO A . n 
A 1 540 GLU 540 576 576 GLU GLU A . n 
A 1 541 ALA 541 577 577 ALA ALA A . n 
A 1 542 MET 542 578 578 MET MET A . n 
A 1 543 GLN 543 579 579 GLN GLN A . n 
A 1 544 LEU 544 580 580 LEU LEU A . n 
A 1 545 ILE 545 581 581 ILE ILE A . n 
A 1 546 THR 546 582 582 THR THR A . n 
A 1 547 GLY 547 583 583 GLY GLY A . n 
A 1 548 GLN 548 584 584 GLN GLN A . n 
A 1 549 PRO 549 585 585 PRO PRO A . n 
A 1 550 GLN 550 586 586 GLN GLN A . n 
A 1 551 MET 551 587 587 MET MET A . n 
A 1 552 SER 552 588 588 SER SER A . n 
A 1 553 ALA 553 589 589 ALA ALA A . n 
A 1 554 SER 554 590 590 SER SER A . n 
A 1 555 ALA 555 591 591 ALA ALA A . n 
A 1 556 MET 556 592 592 MET MET A . n 
A 1 557 LEU 557 593 593 LEU LEU A . n 
A 1 558 SER 558 594 594 SER SER A . n 
A 1 559 TYR 559 595 595 TYR TYR A . n 
A 1 560 PHE 560 596 596 PHE PHE A . n 
A 1 561 LYS 561 597 597 LYS LYS A . n 
A 1 562 PRO 562 598 598 PRO PRO A . n 
A 1 563 LEU 563 599 599 LEU LEU A . n 
A 1 564 LEU 564 600 600 LEU LEU A . n 
A 1 565 ASP 565 601 601 ASP ASP A . n 
A 1 566 TRP 566 602 602 TRP TRP A . n 
A 1 567 LEU 567 603 603 LEU LEU A . n 
A 1 568 ARG 568 604 604 ARG ARG A . n 
A 1 569 THR 569 605 605 THR THR A . n 
A 1 570 GLU 570 606 606 GLU GLU A . n 
A 1 571 ASN 571 607 607 ASN ASN A . n 
A 1 572 GLU 572 608 608 GLU GLU A . n 
A 1 573 LEU 573 609 609 LEU LEU A . n 
A 1 574 HIS 574 610 610 HIS HIS A . n 
A 1 575 GLY 575 611 611 GLY GLY A . n 
A 1 576 GLU 576 612 612 GLU GLU A . n 
A 1 577 LYS 577 613 613 LYS LYS A . n 
A 1 578 LEU 578 614 614 LEU LEU A . n 
A 1 579 GLY 579 615 615 GLY GLY A . n 
A 1 580 TRP 580 616 616 TRP TRP A . n 
A 1 581 PRO 581 617 ?   ?   ?   A . n 
A 1 582 GLN 582 618 ?   ?   ?   A . n 
A 1 583 TYR 583 619 ?   ?   ?   A . n 
A 1 584 ASN 584 620 ?   ?   ?   A . n 
A 1 585 TRP 585 621 ?   ?   ?   A . n 
A 1 586 THR 586 622 ?   ?   ?   A . n 
A 1 587 PRO 587 623 ?   ?   ?   A . n 
A 1 588 ASN 588 624 ?   ?   ?   A . n 
A 1 589 SER 589 625 ?   ?   ?   A . n 
A 1 590 ALA 590 626 ?   ?   ?   A . n 
A 1 591 ARG 591 627 ?   ?   ?   A . n 
A 1 592 SER 592 628 ?   ?   ?   A . n 
A 1 593 GLU 593 629 ?   ?   ?   A . n 
A 1 594 GLY 594 630 ?   ?   ?   A . n 
A 1 595 PRO 595 631 ?   ?   ?   A . n 
A 1 596 LEU 596 632 ?   ?   ?   A . n 
A 1 597 PRO 597 633 ?   ?   ?   A . n 
# 
loop_
_pdbx_branch_scheme.asym_id 
_pdbx_branch_scheme.entity_id 
_pdbx_branch_scheme.mon_id 
_pdbx_branch_scheme.num 
_pdbx_branch_scheme.pdb_asym_id 
_pdbx_branch_scheme.pdb_mon_id 
_pdbx_branch_scheme.pdb_seq_num 
_pdbx_branch_scheme.auth_asym_id 
_pdbx_branch_scheme.auth_mon_id 
_pdbx_branch_scheme.auth_seq_num 
_pdbx_branch_scheme.hetero 
B 2 NAG 1 B NAG 1 B NAG 1 n 
B 2 NAG 2 B NAG 2 B NAG 2 n 
B 2 BMA 3 B BMA 3 B BMA 3 n 
B 2 FUC 4 B FUC 4 B FUC 5 n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 ZN    ? ? ZN    ? ? 'SUBJECT OF INVESTIGATION' ? 
2 A1IJW ? ? A1IJW ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 3  ZN    1   701  701  ZN    ZN  A . 
D 4  PEG   1   702  703  PEG   PEG A . 
E 5  EDO   1   703  705  EDO   EDO A . 
F 6  BO3   1   704  706  BO3   BO3 A . 
G 7  CL    1   705  709  CL    CL  A . 
H 7  CL    1   706  710  CL    CL  A . 
I 8  A1IJW 1   707  1123 A1IJW SG3 A . 
J 9  NAG   1   708  704  NAG   NAG A . 
K 10 HOH   1   801  805  HOH   HOH A . 
K 10 HOH   2   802  801  HOH   HOH A . 
K 10 HOH   3   803  802  HOH   HOH A . 
K 10 HOH   4   804  808  HOH   HOH A . 
K 10 HOH   5   805  803  HOH   HOH A . 
K 10 HOH   6   806  804  HOH   HOH A . 
K 10 HOH   7   807  820  HOH   HOH A . 
K 10 HOH   8   808  806  HOH   HOH A . 
K 10 HOH   9   809  810  HOH   HOH A . 
K 10 HOH   10  810  807  HOH   HOH A . 
K 10 HOH   11  811  812  HOH   HOH A . 
K 10 HOH   12  812  815  HOH   HOH A . 
K 10 HOH   13  813  809  HOH   HOH A . 
K 10 HOH   14  814  811  HOH   HOH A . 
K 10 HOH   15  815  814  HOH   HOH A . 
K 10 HOH   16  816  819  HOH   HOH A . 
K 10 HOH   17  817  817  HOH   HOH A . 
K 10 HOH   18  818  827  HOH   HOH A . 
K 10 HOH   19  819  834  HOH   HOH A . 
K 10 HOH   20  820  813  HOH   HOH A . 
K 10 HOH   21  821  818  HOH   HOH A . 
K 10 HOH   22  822  824  HOH   HOH A . 
K 10 HOH   23  823  828  HOH   HOH A . 
K 10 HOH   24  824  823  HOH   HOH A . 
K 10 HOH   25  825  821  HOH   HOH A . 
K 10 HOH   26  826  837  HOH   HOH A . 
K 10 HOH   27  827  829  HOH   HOH A . 
K 10 HOH   28  828  816  HOH   HOH A . 
K 10 HOH   29  829  833  HOH   HOH A . 
K 10 HOH   30  830  825  HOH   HOH A . 
K 10 HOH   31  831  840  HOH   HOH A . 
K 10 HOH   32  832  831  HOH   HOH A . 
K 10 HOH   33  833  822  HOH   HOH A . 
K 10 HOH   34  834  865  HOH   HOH A . 
K 10 HOH   35  835  841  HOH   HOH A . 
K 10 HOH   36  836  886  HOH   HOH A . 
K 10 HOH   37  837  836  HOH   HOH A . 
K 10 HOH   38  838  826  HOH   HOH A . 
K 10 HOH   39  839  846  HOH   HOH A . 
K 10 HOH   40  840  838  HOH   HOH A . 
K 10 HOH   41  841  850  HOH   HOH A . 
K 10 HOH   42  842  848  HOH   HOH A . 
K 10 HOH   43  843  847  HOH   HOH A . 
K 10 HOH   44  844  858  HOH   HOH A . 
K 10 HOH   45  845  832  HOH   HOH A . 
K 10 HOH   46  846  871  HOH   HOH A . 
K 10 HOH   47  847  842  HOH   HOH A . 
K 10 HOH   48  848  867  HOH   HOH A . 
K 10 HOH   49  849  843  HOH   HOH A . 
K 10 HOH   50  850  919  HOH   HOH A . 
K 10 HOH   51  851  869  HOH   HOH A . 
K 10 HOH   52  852  835  HOH   HOH A . 
K 10 HOH   53  853  830  HOH   HOH A . 
K 10 HOH   54  854  849  HOH   HOH A . 
K 10 HOH   55  855  855  HOH   HOH A . 
K 10 HOH   56  856  861  HOH   HOH A . 
K 10 HOH   57  857  854  HOH   HOH A . 
K 10 HOH   58  858  857  HOH   HOH A . 
K 10 HOH   59  859  852  HOH   HOH A . 
K 10 HOH   60  860  862  HOH   HOH A . 
K 10 HOH   61  861  839  HOH   HOH A . 
K 10 HOH   62  862  864  HOH   HOH A . 
K 10 HOH   63  863  926  HOH   HOH A . 
K 10 HOH   64  864  873  HOH   HOH A . 
K 10 HOH   65  865  883  HOH   HOH A . 
K 10 HOH   66  866  853  HOH   HOH A . 
K 10 HOH   67  867  844  HOH   HOH A . 
K 10 HOH   68  868  860  HOH   HOH A . 
K 10 HOH   69  869  859  HOH   HOH A . 
K 10 HOH   70  870  882  HOH   HOH A . 
K 10 HOH   71  871  884  HOH   HOH A . 
K 10 HOH   72  872  903  HOH   HOH A . 
K 10 HOH   73  873  874  HOH   HOH A . 
K 10 HOH   74  874  851  HOH   HOH A . 
K 10 HOH   75  875  845  HOH   HOH A . 
K 10 HOH   76  876  891  HOH   HOH A . 
K 10 HOH   77  877  870  HOH   HOH A . 
K 10 HOH   78  878  944  HOH   HOH A . 
K 10 HOH   79  879  888  HOH   HOH A . 
K 10 HOH   80  880  876  HOH   HOH A . 
K 10 HOH   81  881  866  HOH   HOH A . 
K 10 HOH   82  882  889  HOH   HOH A . 
K 10 HOH   83  883  935  HOH   HOH A . 
K 10 HOH   84  884  863  HOH   HOH A . 
K 10 HOH   85  885  906  HOH   HOH A . 
K 10 HOH   86  886  909  HOH   HOH A . 
K 10 HOH   87  887  890  HOH   HOH A . 
K 10 HOH   88  888  956  HOH   HOH A . 
K 10 HOH   89  889  881  HOH   HOH A . 
K 10 HOH   90  890  901  HOH   HOH A . 
K 10 HOH   91  891  893  HOH   HOH A . 
K 10 HOH   92  892  879  HOH   HOH A . 
K 10 HOH   93  893  880  HOH   HOH A . 
K 10 HOH   94  894  912  HOH   HOH A . 
K 10 HOH   95  895  920  HOH   HOH A . 
K 10 HOH   96  896  900  HOH   HOH A . 
K 10 HOH   97  897  885  HOH   HOH A . 
K 10 HOH   98  898  902  HOH   HOH A . 
K 10 HOH   99  899  887  HOH   HOH A . 
K 10 HOH   100 900  910  HOH   HOH A . 
K 10 HOH   101 901  898  HOH   HOH A . 
K 10 HOH   102 902  875  HOH   HOH A . 
K 10 HOH   103 903  856  HOH   HOH A . 
K 10 HOH   104 904  894  HOH   HOH A . 
K 10 HOH   105 905  892  HOH   HOH A . 
K 10 HOH   106 906  911  HOH   HOH A . 
K 10 HOH   107 907  908  HOH   HOH A . 
K 10 HOH   108 908  868  HOH   HOH A . 
K 10 HOH   109 909  896  HOH   HOH A . 
K 10 HOH   110 910  913  HOH   HOH A . 
K 10 HOH   111 911  916  HOH   HOH A . 
K 10 HOH   112 912  877  HOH   HOH A . 
K 10 HOH   113 913  994  HOH   HOH A . 
K 10 HOH   114 914  915  HOH   HOH A . 
K 10 HOH   115 915  899  HOH   HOH A . 
K 10 HOH   116 916  932  HOH   HOH A . 
K 10 HOH   117 917  927  HOH   HOH A . 
K 10 HOH   118 918  895  HOH   HOH A . 
K 10 HOH   119 919  950  HOH   HOH A . 
K 10 HOH   120 920  905  HOH   HOH A . 
K 10 HOH   121 921  943  HOH   HOH A . 
K 10 HOH   122 922  938  HOH   HOH A . 
K 10 HOH   123 923  914  HOH   HOH A . 
K 10 HOH   124 924  937  HOH   HOH A . 
K 10 HOH   125 925  917  HOH   HOH A . 
K 10 HOH   126 926  928  HOH   HOH A . 
K 10 HOH   127 927  952  HOH   HOH A . 
K 10 HOH   128 928  972  HOH   HOH A . 
K 10 HOH   129 929  945  HOH   HOH A . 
K 10 HOH   130 930  923  HOH   HOH A . 
K 10 HOH   131 931  929  HOH   HOH A . 
K 10 HOH   132 932  904  HOH   HOH A . 
K 10 HOH   133 933  949  HOH   HOH A . 
K 10 HOH   134 934  878  HOH   HOH A . 
K 10 HOH   135 935  872  HOH   HOH A . 
K 10 HOH   136 936  965  HOH   HOH A . 
K 10 HOH   137 937  922  HOH   HOH A . 
K 10 HOH   138 938  931  HOH   HOH A . 
K 10 HOH   139 939  955  HOH   HOH A . 
K 10 HOH   140 940  940  HOH   HOH A . 
K 10 HOH   141 941  941  HOH   HOH A . 
K 10 HOH   142 942  942  HOH   HOH A . 
K 10 HOH   143 943  933  HOH   HOH A . 
K 10 HOH   144 944  948  HOH   HOH A . 
K 10 HOH   145 945  934  HOH   HOH A . 
K 10 HOH   146 946  946  HOH   HOH A . 
K 10 HOH   147 947  918  HOH   HOH A . 
K 10 HOH   148 948  951  HOH   HOH A . 
K 10 HOH   149 949  1011 HOH   HOH A . 
K 10 HOH   150 950  953  HOH   HOH A . 
K 10 HOH   151 951  959  HOH   HOH A . 
K 10 HOH   152 952  925  HOH   HOH A . 
K 10 HOH   153 953  907  HOH   HOH A . 
K 10 HOH   154 954  960  HOH   HOH A . 
K 10 HOH   155 955  966  HOH   HOH A . 
K 10 HOH   156 956  897  HOH   HOH A . 
K 10 HOH   157 957  975  HOH   HOH A . 
K 10 HOH   158 958  961  HOH   HOH A . 
K 10 HOH   159 959  957  HOH   HOH A . 
K 10 HOH   160 960  921  HOH   HOH A . 
K 10 HOH   161 961  947  HOH   HOH A . 
K 10 HOH   162 962  967  HOH   HOH A . 
K 10 HOH   163 963  971  HOH   HOH A . 
K 10 HOH   164 964  924  HOH   HOH A . 
K 10 HOH   165 965  936  HOH   HOH A . 
K 10 HOH   166 966  939  HOH   HOH A . 
K 10 HOH   167 967  954  HOH   HOH A . 
K 10 HOH   168 968  964  HOH   HOH A . 
K 10 HOH   169 969  970  HOH   HOH A . 
K 10 HOH   170 970  981  HOH   HOH A . 
K 10 HOH   171 971  990  HOH   HOH A . 
K 10 HOH   172 972  997  HOH   HOH A . 
K 10 HOH   173 973  980  HOH   HOH A . 
K 10 HOH   174 974  962  HOH   HOH A . 
K 10 HOH   175 975  992  HOH   HOH A . 
K 10 HOH   176 976  991  HOH   HOH A . 
K 10 HOH   177 977  963  HOH   HOH A . 
K 10 HOH   178 978  978  HOH   HOH A . 
K 10 HOH   179 979  985  HOH   HOH A . 
K 10 HOH   180 980  983  HOH   HOH A . 
K 10 HOH   181 981  969  HOH   HOH A . 
K 10 HOH   182 982  987  HOH   HOH A . 
K 10 HOH   183 983  995  HOH   HOH A . 
K 10 HOH   184 984  968  HOH   HOH A . 
K 10 HOH   185 985  982  HOH   HOH A . 
K 10 HOH   186 986  977  HOH   HOH A . 
K 10 HOH   187 987  976  HOH   HOH A . 
K 10 HOH   188 988  984  HOH   HOH A . 
K 10 HOH   189 989  999  HOH   HOH A . 
K 10 HOH   190 990  998  HOH   HOH A . 
K 10 HOH   191 991  1022 HOH   HOH A . 
K 10 HOH   192 992  989  HOH   HOH A . 
K 10 HOH   193 993  1001 HOH   HOH A . 
K 10 HOH   194 994  996  HOH   HOH A . 
K 10 HOH   195 995  1005 HOH   HOH A . 
K 10 HOH   196 996  1000 HOH   HOH A . 
K 10 HOH   197 997  993  HOH   HOH A . 
K 10 HOH   198 998  1003 HOH   HOH A . 
K 10 HOH   199 999  1004 HOH   HOH A . 
K 10 HOH   200 1000 1002 HOH   HOH A . 
K 10 HOH   201 1001 1013 HOH   HOH A . 
K 10 HOH   202 1002 973  HOH   HOH A . 
K 10 HOH   203 1003 988  HOH   HOH A . 
K 10 HOH   204 1004 930  HOH   HOH A . 
K 10 HOH   205 1005 974  HOH   HOH A . 
K 10 HOH   206 1006 1010 HOH   HOH A . 
K 10 HOH   207 1007 1007 HOH   HOH A . 
K 10 HOH   208 1008 1021 HOH   HOH A . 
K 10 HOH   209 1009 1023 HOH   HOH A . 
K 10 HOH   210 1010 1020 HOH   HOH A . 
K 10 HOH   211 1011 1040 HOH   HOH A . 
K 10 HOH   212 1012 1019 HOH   HOH A . 
K 10 HOH   213 1013 1028 HOH   HOH A . 
K 10 HOH   214 1014 1034 HOH   HOH A . 
K 10 HOH   215 1015 1008 HOH   HOH A . 
K 10 HOH   216 1016 1006 HOH   HOH A . 
K 10 HOH   217 1017 1036 HOH   HOH A . 
K 10 HOH   218 1018 1014 HOH   HOH A . 
K 10 HOH   219 1019 1009 HOH   HOH A . 
K 10 HOH   220 1020 1015 HOH   HOH A . 
K 10 HOH   221 1021 1031 HOH   HOH A . 
K 10 HOH   222 1022 1032 HOH   HOH A . 
K 10 HOH   223 1023 1033 HOH   HOH A . 
K 10 HOH   224 1024 1016 HOH   HOH A . 
K 10 HOH   225 1025 958  HOH   HOH A . 
K 10 HOH   226 1026 1052 HOH   HOH A . 
K 10 HOH   227 1027 1017 HOH   HOH A . 
K 10 HOH   228 1028 1029 HOH   HOH A . 
K 10 HOH   229 1029 1012 HOH   HOH A . 
K 10 HOH   230 1030 1025 HOH   HOH A . 
K 10 HOH   231 1031 1026 HOH   HOH A . 
K 10 HOH   232 1032 986  HOH   HOH A . 
K 10 HOH   233 1033 1049 HOH   HOH A . 
K 10 HOH   234 1034 1054 HOH   HOH A . 
K 10 HOH   235 1035 1024 HOH   HOH A . 
K 10 HOH   236 1036 979  HOH   HOH A . 
K 10 HOH   237 1037 1041 HOH   HOH A . 
K 10 HOH   238 1038 1035 HOH   HOH A . 
K 10 HOH   239 1039 1047 HOH   HOH A . 
K 10 HOH   240 1040 1038 HOH   HOH A . 
K 10 HOH   241 1041 1039 HOH   HOH A . 
K 10 HOH   242 1042 1018 HOH   HOH A . 
K 10 HOH   243 1043 1044 HOH   HOH A . 
K 10 HOH   244 1044 1043 HOH   HOH A . 
K 10 HOH   245 1045 1037 HOH   HOH A . 
K 10 HOH   246 1046 1027 HOH   HOH A . 
K 10 HOH   247 1047 1046 HOH   HOH A . 
K 10 HOH   248 1048 1056 HOH   HOH A . 
K 10 HOH   249 1049 1042 HOH   HOH A . 
K 10 HOH   250 1050 1030 HOH   HOH A . 
K 10 HOH   251 1051 1053 HOH   HOH A . 
K 10 HOH   252 1052 1045 HOH   HOH A . 
K 10 HOH   253 1053 1066 HOH   HOH A . 
K 10 HOH   254 1054 1051 HOH   HOH A . 
K 10 HOH   255 1055 1057 HOH   HOH A . 
K 10 HOH   256 1056 1061 HOH   HOH A . 
K 10 HOH   257 1057 1077 HOH   HOH A . 
K 10 HOH   258 1058 1048 HOH   HOH A . 
K 10 HOH   259 1059 1060 HOH   HOH A . 
K 10 HOH   260 1060 1055 HOH   HOH A . 
K 10 HOH   261 1061 1063 HOH   HOH A . 
K 10 HOH   262 1062 1058 HOH   HOH A . 
K 10 HOH   263 1063 1050 HOH   HOH A . 
K 10 HOH   264 1064 1062 HOH   HOH A . 
K 10 HOH   265 1065 1059 HOH   HOH A . 
K 10 HOH   266 1066 1064 HOH   HOH A . 
K 10 HOH   267 1067 1079 HOH   HOH A . 
K 10 HOH   268 1068 1068 HOH   HOH A . 
K 10 HOH   269 1069 1065 HOH   HOH A . 
K 10 HOH   270 1070 1067 HOH   HOH A . 
K 10 HOH   271 1071 1082 HOH   HOH A . 
K 10 HOH   272 1072 1070 HOH   HOH A . 
K 10 HOH   273 1073 1072 HOH   HOH A . 
K 10 HOH   274 1074 1087 HOH   HOH A . 
K 10 HOH   275 1075 1078 HOH   HOH A . 
K 10 HOH   276 1076 1071 HOH   HOH A . 
K 10 HOH   277 1077 1074 HOH   HOH A . 
K 10 HOH   278 1078 1073 HOH   HOH A . 
K 10 HOH   279 1079 1075 HOH   HOH A . 
K 10 HOH   280 1080 1081 HOH   HOH A . 
K 10 HOH   281 1081 1080 HOH   HOH A . 
K 10 HOH   282 1082 1076 HOH   HOH A . 
K 10 HOH   283 1083 1084 HOH   HOH A . 
K 10 HOH   284 1084 1086 HOH   HOH A . 
K 10 HOH   285 1085 1085 HOH   HOH A . 
K 10 HOH   286 1086 1083 HOH   HOH A . 
K 10 HOH   287 1087 1089 HOH   HOH A . 
K 10 HOH   288 1088 1092 HOH   HOH A . 
K 10 HOH   289 1089 1090 HOH   HOH A . 
K 10 HOH   290 1090 1088 HOH   HOH A . 
K 10 HOH   291 1091 1091 HOH   HOH A . 
K 10 HOH   292 1092 1093 HOH   HOH A . 
K 10 HOH   293 1093 1096 HOH   HOH A . 
K 10 HOH   294 1094 1095 HOH   HOH A . 
K 10 HOH   295 1095 1097 HOH   HOH A . 
K 10 HOH   296 1096 1094 HOH   HOH A . 
K 10 HOH   297 1097 1098 HOH   HOH A . 
K 10 HOH   298 1098 1100 HOH   HOH A . 
K 10 HOH   299 1099 1099 HOH   HOH A . 
K 10 HOH   300 1100 1101 HOH   HOH A . 
K 10 HOH   301 1101 1104 HOH   HOH A . 
K 10 HOH   302 1102 1102 HOH   HOH A . 
K 10 HOH   303 1103 1103 HOH   HOH A . 
K 10 HOH   304 1104 1106 HOH   HOH A . 
K 10 HOH   305 1105 1107 HOH   HOH A . 
K 10 HOH   306 1106 1105 HOH   HOH A . 
K 10 HOH   307 1107 1108 HOH   HOH A . 
K 10 HOH   308 1108 1109 HOH   HOH A . 
K 10 HOH   309 1109 1113 HOH   HOH A . 
K 10 HOH   310 1110 1110 HOH   HOH A . 
K 10 HOH   311 1111 1111 HOH   HOH A . 
K 10 HOH   312 1112 1119 HOH   HOH A . 
K 10 HOH   313 1113 1114 HOH   HOH A . 
K 10 HOH   314 1114 1112 HOH   HOH A . 
K 10 HOH   315 1115 1115 HOH   HOH A . 
K 10 HOH   316 1116 1116 HOH   HOH A . 
K 10 HOH   317 1117 1118 HOH   HOH A . 
K 10 HOH   318 1118 1120 HOH   HOH A . 
K 10 HOH   319 1119 1117 HOH   HOH A . 
K 10 HOH   320 1120 1121 HOH   HOH A . 
K 10 HOH   321 1121 1122 HOH   HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC  ? ? ? 5.8.0425 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? DIALS   ? ? ? .        2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .        3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER  ? ? ? .        4 
# 
_cell.angle_alpha                  90 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9GBM 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     55.886 
_cell.length_a_esd                 ? 
_cell.length_b                     84.131 
_cell.length_b_esd                 ? 
_cell.length_c                     132.664 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9GBM 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9GBM 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.34 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          47.44 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1 M MIB pH 4.0, 5% glycerol, and 15% PEG 3350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            289.15 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 XE 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2019-09-21 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.9159 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'DIAMOND BEAMLINE I04' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.9159 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   I04 
_diffrn_source.pdbx_synchrotron_site       Diamond 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9GBM 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.9 
_reflns.d_resolution_low                               132.66 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     50194 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           100 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                12.2 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          8.5 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                0.057 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.996 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.90 
_reflns_shell.d_res_low                                     1.94 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           1.5 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             3201 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               0.503 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.579 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            -1.157 
_refine.aniso_B[1][2]                            -0.000 
_refine.aniso_B[1][3]                            0.000 
_refine.aniso_B[2][2]                            1.643 
_refine.aniso_B[2][3]                            -0.000 
_refine.aniso_B[3][3]                            -0.486 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               27.778 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.965 
_refine.correlation_coeff_Fo_to_Fc_free          0.945 
_refine.details                                  'Hydrogens have not been used' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9GBM 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.900 
_refine.ls_d_res_low                             71.149 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     50106 
_refine.ls_number_reflns_R_free                  2395 
_refine.ls_number_reflns_R_work                  47711 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.968 
_refine.ls_percent_reflns_R_free                 4.780 
_refine.ls_R_factor_all                          0.170 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_R_free                       0.2170 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1678 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      0.205 
_refine.ls_wR_factor_R_work                      0.158 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'MASK BULK SOLVENT' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.141 
_refine.pdbx_overall_ESU_R_Free                  0.138 
_refine.pdbx_solvent_vdw_probe_radii             1.200 
_refine.pdbx_solvent_ion_probe_radii             0.800 
_refine.pdbx_solvent_shrinkage_radii             0.800 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             3.808 
_refine.overall_SU_ML                            0.107 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    0.9760 
_refine.pdbx_average_fsc_free                    0.9610 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.900 
_refine_hist.d_res_low                        71.149 
_refine_hist.number_atoms_solvent             321 
_refine_hist.number_atoms_total               5092 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        4659 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         112 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.015  0.012  4975 ? r_bond_refined_d               ? ? 
'X-RAY DIFFRACTION' ? 2.532  1.837  6776 ? r_angle_refined_deg            ? ? 
'X-RAY DIFFRACTION' ? 6.276  5.000  584  ? r_dihedral_angle_1_deg         ? ? 
'X-RAY DIFFRACTION' ? 8.516  5.000  26   ? r_dihedral_angle_2_deg         ? ? 
'X-RAY DIFFRACTION' ? 14.731 10.000 810  ? r_dihedral_angle_3_deg         ? ? 
'X-RAY DIFFRACTION' ? 15.107 10.000 241  ? r_dihedral_angle_6_deg         ? ? 
'X-RAY DIFFRACTION' ? 0.155  0.200  723  ? r_chiral_restr                 ? ? 
'X-RAY DIFFRACTION' ? 0.015  0.020  3909 ? r_gen_planes_refined           ? ? 
'X-RAY DIFFRACTION' ? 0.222  0.200  2529 ? r_nbd_refined                  ? ? 
'X-RAY DIFFRACTION' ? 0.322  0.200  3458 ? r_nbtor_refined                ? ? 
'X-RAY DIFFRACTION' ? 0.167  0.200  362  ? r_xyhbond_nbd_refined          ? ? 
'X-RAY DIFFRACTION' ? 0.204  0.200  56   ? r_symmetry_nbd_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.241  0.200  7    ? r_symmetry_xyhbond_nbd_refined ? ? 
'X-RAY DIFFRACTION' ? 3.067  2.442  2321 ? r_mcbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 3.892  4.366  2910 ? r_mcangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 5.448  2.902  2654 ? r_scbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 7.796  5.100  3866 ? r_scangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 8.172  28.786 8071 ? r_lrange_it                    ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.900 1.949  3666 . 175 3490 99.9727  . 0.251 . . 0.250 . . . . . 0.248 . 20 . 0.950 0.933 0.281 
'X-RAY DIFFRACTION' 1.949 2.003  3568 . 161 3404 99.9159  . 0.243 . . 0.241 . . . . . 0.237 . 20 . 0.955 0.930 0.294 
'X-RAY DIFFRACTION' 2.003 2.061  3466 . 162 3301 99.9134  . 0.221 . . 0.220 . . . . . 0.211 . 20 . 0.964 0.959 0.246 
'X-RAY DIFFRACTION' 2.061 2.124  3339 . 153 3186 100.0000 . 0.192 . . 0.190 . . . . . 0.180 . 20 . 0.975 0.962 0.228 
'X-RAY DIFFRACTION' 2.124 2.194  3281 . 153 3128 100.0000 . 0.199 . . 0.195 . . . . . 0.182 . 20 . 0.973 0.952 0.285 
'X-RAY DIFFRACTION' 2.194 2.271  3148 . 162 2984 99.9365  . 0.191 . . 0.186 . . . . . 0.172 . 20 . 0.975 0.946 0.292 
'X-RAY DIFFRACTION' 2.271 2.356  3063 . 143 2919 99.9674  . 0.172 . . 0.168 . . . . . 0.154 . 20 . 0.981 0.966 0.240 
'X-RAY DIFFRACTION' 2.356 2.452  2954 . 118 2836 100.0000 . 0.169 . . 0.166 . . . . . 0.151 . 20 . 0.982 0.955 0.254 
'X-RAY DIFFRACTION' 2.452 2.561  2831 . 155 2674 99.9294  . 0.176 . . 0.173 . . . . . 0.158 . 20 . 0.981 0.971 0.218 
'X-RAY DIFFRACTION' 2.561 2.686  2718 . 134 2583 99.9632  . 0.175 . . 0.170 . . . . . 0.156 . 20 . 0.982 0.953 0.292 
'X-RAY DIFFRACTION' 2.686 2.831  2579 . 123 2456 100.0000 . 0.171 . . 0.169 . . . . . 0.155 . 20 . 0.983 0.968 0.226 
'X-RAY DIFFRACTION' 2.831 3.003  2448 . 129 2319 100.0000 . 0.160 . . 0.158 . . . . . 0.148 . 20 . 0.984 0.975 0.204 
'X-RAY DIFFRACTION' 3.003 3.210  2314 . 111 2203 100.0000 . 0.170 . . 0.168 . . . . . 0.159 . 20 . 0.982 0.971 0.207 
'X-RAY DIFFRACTION' 3.210 3.466  2164 . 98  2064 99.9076  . 0.173 . . 0.171 . . . . . 0.163 . 20 . 0.981 0.973 0.220 
'X-RAY DIFFRACTION' 3.466 3.796  1999 . 84  1915 100.0000 . 0.152 . . 0.150 . . . . . 0.146 . 20 . 0.987 0.975 0.205 
'X-RAY DIFFRACTION' 3.796 4.243  1823 . 96  1726 99.9451  . 0.130 . . 0.128 . . . . . 0.128 . 20 . 0.991 0.984 0.161 
'X-RAY DIFFRACTION' 4.243 4.896  1607 . 77  1530 100.0000 . 0.132 . . 0.130 . . . . . 0.133 . 20 . 0.990 0.985 0.161 
'X-RAY DIFFRACTION' 4.896 5.989  1392 . 77  1315 100.0000 . 0.151 . . 0.150 . . . . . 0.152 . 20 . 0.987 0.980 0.179 
'X-RAY DIFFRACTION' 5.989 8.440  1101 . 57  1044 100.0000 . 0.158 . . 0.157 . . . . . 0.161 . 20 . 0.986 0.985 0.173 
'X-RAY DIFFRACTION' 8.440 71.149 661  . 27  634  100.0000 . 0.174 . . 0.173 . . . . . 0.186 . 20 . 0.980 0.979 0.177 
# 
_struct.entry_id                     9GBM 
_struct.title                        'Human Angiotensin-1 converting enzyme C-domain in complex with a diprolyl inhibitor- SG3' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9GBM 
_struct_keywords.text            'Inhibitor, complex, protease, HYDROLASE' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1  ? 
B N N 2  ? 
C N N 3  ? 
D N N 4  ? 
E N N 5  ? 
F N N 6  ? 
G N N 7  ? 
H N N 7  ? 
I N N 8  ? 
J N N 9  ? 
K N N 10 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    ACE_HUMAN 
_struct_ref.pdbx_db_accession          P12821 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;LVTDEAEASKFVEEYDRTSQVVWNEYAEANWNYNTNITTETSKILLQKNMQIANHTLKYGTQARKFDVNQLQNTTIKRII
KKVQDLERAALPAQELEEYNKILLDMETTYSVATVCHPNGSCLQLEPDLTNVMATSRKYEDLLWAWEGWRDKAGRAILQF
YPKYVELINQAARLNGYVDAGDSWRSMYETPSLEQDLERLFQELQPLYLNLHAYVRRALHRHYGAQHINLEGPIPAHLLG
NMWAQTWSNIYDLVVPFPSAPSMDTTEAMLKQGWTPRRMFKEADDFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHASA
WDFYNGKDFRIKQCTTVNLEDLVVAHHEMGHIQYFMQYKDLPVALREGANPGFHEAIGDVLALSVSTPKHLHSLNLLSSE
GGSDEHDINFLMKMALDKIAFIPFSYLVDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRTQGDFDPGAKFHIPS
SVPYIRYFVSFIIQFQFHEALCQAAGHTGPLHKCDIYQSKEAGQRLATAMKLGFSRPWPEAMQLITGQPNMSASAMLSYF
KPLLDWLRTENELHGEKLGWPQYNWTPNSARSEGPLP
;
_struct_ref.pdbx_align_begin           642 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9GBM 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 597 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P12821 
_struct_ref_seq.db_align_beg                  642 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  1238 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       37 
_struct_ref_seq.pdbx_auth_seq_align_end       633 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9GBM GLY A 28  ? UNP P12821 GLU 669  'engineered mutation' 64  1 
1 9GBM GLN A 54  ? UNP P12821 ASN 695  'engineered mutation' 90  2 
1 9GBM GLN A 119 ? UNP P12821 ASN 760  'engineered mutation' 155 3 
1 9GBM GLN A 301 ? UNP P12821 ASN 942  'engineered mutation' 337 4 
1 9GBM GLN A 550 ? UNP P12821 ASN 1191 'engineered mutation' 586 5 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 2250  ? 
1 MORE         0     ? 
1 'SSA (A^2)'  22970 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 GLU A 5   ? THR A 35  ? GLU A 41  THR A 71  1 ? 31 
HELX_P HELX_P2  AA2 THR A 38  ? ARG A 64  ? THR A 74  ARG A 100 1 ? 27 
HELX_P HELX_P3  AA3 LYS A 65  ? PHE A 66  ? LYS A 101 PHE A 102 5 ? 2  
HELX_P HELX_P4  AA4 ASP A 67  ? LEU A 71  ? ASP A 103 LEU A 107 5 ? 5  
HELX_P HELX_P5  AA5 ASN A 73  ? GLN A 84  ? ASN A 109 GLN A 120 1 ? 12 
HELX_P HELX_P6  AA6 LEU A 86  ? LEU A 91  ? LEU A 122 LEU A 127 5 ? 6  
HELX_P HELX_P7  AA7 PRO A 92  ? ALA A 113 ? PRO A 128 ALA A 149 1 ? 22 
HELX_P HELX_P8  AA8 PRO A 127 ? SER A 136 ? PRO A 163 SER A 172 1 ? 10 
HELX_P HELX_P9  AA9 LYS A 138 ? ALA A 153 ? LYS A 174 ALA A 189 1 ? 16 
HELX_P HELX_P10 AB1 ALA A 153 ? LEU A 158 ? ALA A 189 LEU A 194 1 ? 6  
HELX_P HELX_P11 AB2 PHE A 160 ? ASN A 175 ? PHE A 196 ASN A 211 1 ? 16 
HELX_P HELX_P12 AB3 ASP A 179 ? MET A 187 ? ASP A 215 MET A 223 1 ? 9  
HELX_P HELX_P13 AB4 SER A 192 ? LEU A 204 ? SER A 228 LEU A 240 1 ? 13 
HELX_P HELX_P14 AB5 LEU A 204 ? GLY A 224 ? LEU A 240 GLY A 260 1 ? 21 
HELX_P HELX_P15 AB6 TRP A 247 ? ASN A 249 ? TRP A 283 ASN A 285 5 ? 3  
HELX_P HELX_P16 AB7 ILE A 250 ? VAL A 255 ? ILE A 286 VAL A 291 1 ? 6  
HELX_P HELX_P17 AB8 ASP A 264 ? GLN A 272 ? ASP A 300 GLN A 308 1 ? 9  
HELX_P HELX_P18 AB9 THR A 275 ? LEU A 290 ? THR A 311 LEU A 326 1 ? 16 
HELX_P HELX_P19 AC1 PRO A 296 ? SER A 303 ? PRO A 332 SER A 339 1 ? 8  
HELX_P HELX_P20 AC2 ASN A 338 ? TYR A 358 ? ASN A 374 TYR A 394 1 ? 21 
HELX_P HELX_P21 AC3 PRO A 362 ? ARG A 366 ? PRO A 398 ARG A 402 5 ? 5  
HELX_P HELX_P22 AC4 ASN A 370 ? SER A 386 ? ASN A 406 SER A 422 1 ? 17 
HELX_P HELX_P23 AC5 THR A 387 ? LEU A 394 ? THR A 423 LEU A 430 1 ? 8  
HELX_P HELX_P24 AC6 ASP A 404 ? ILE A 419 ? ASP A 440 ILE A 455 1 ? 16 
HELX_P HELX_P25 AC7 ALA A 420 ? ASP A 437 ? ALA A 456 ASP A 473 1 ? 18 
HELX_P HELX_P26 AC8 ASN A 444 ? GLY A 458 ? ASN A 480 GLY A 494 1 ? 15 
HELX_P HELX_P27 AC9 PHE A 470 ? LYS A 475 ? PHE A 506 LYS A 511 5 ? 6  
HELX_P HELX_P28 AD1 TYR A 484 ? ALA A 505 ? TYR A 520 ALA A 541 1 ? 22 
HELX_P HELX_P29 AD2 PRO A 510 ? CYS A 514 ? PRO A 546 CYS A 550 5 ? 5  
HELX_P HELX_P30 AD3 SER A 519 ? LEU A 532 ? SER A 555 LEU A 568 1 ? 14 
HELX_P HELX_P31 AD4 PRO A 537 ? GLY A 547 ? PRO A 573 GLY A 583 1 ? 11 
HELX_P HELX_P32 AD5 ALA A 553 ? GLY A 575 ? ALA A 589 GLY A 611 1 ? 23 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ?    ? A CYS 116 SG  ? ? ? 1_555 A CYS   122 SG  ? ? A CYS 152 A CYS   158 1_555 ? ? ? ? ? ? ? 2.045 ? ? 
disulf2 disulf ?    ? A CYS 316 SG  ? ? ? 1_555 A CYS   334 SG  ? ? A CYS 352 A CYS   370 1_555 ? ? ? ? ? ? ? 2.105 ? ? 
disulf3 disulf ?    ? A CYS 502 SG  ? ? ? 1_555 A CYS   514 SG  ? ? A CYS 538 A CYS   550 1_555 ? ? ? ? ? ? ? 2.048 ? ? 
covale1 covale one  ? A ASN 36  ND2 ? ? ? 1_555 J NAG   .   C1  ? ? A ASN 72  A NAG   708 1_555 ? ? ? ? ? ? ? 1.458 ? 
N-Glycosylation 
covale2 covale one  ? A ASN 73  ND2 ? ? ? 1_555 B NAG   .   C1  ? ? A ASN 109 B NAG   1   1_555 ? ? ? ? ? ? ? 1.406 ? 
N-Glycosylation 
covale3 covale both ? B NAG .   O4  ? ? ? 1_555 B NAG   .   C1  ? ? B NAG 1   B NAG   2   1_555 ? ? ? ? ? ? ? 1.383 ? ? 
covale4 covale both ? B NAG .   O6  ? ? ? 1_555 B FUC   .   C1  ? ? B NAG 1   B FUC   4   1_555 ? ? ? ? ? ? ? 1.403 ? ? 
covale5 covale both ? B NAG .   O4  ? ? ? 1_555 B BMA   .   C1  ? ? B NAG 2   B BMA   3   1_555 ? ? ? ? ? ? ? 1.408 ? ? 
metalc1 metalc ?    ? A HIS 347 NE2 ? ? ? 1_555 C ZN    .   ZN  ? ? A HIS 383 A ZN    701 1_555 ? ? ? ? ? ? ? 1.935 ? ? 
metalc2 metalc ?    ? A HIS 351 NE2 ? ? ? 1_555 C ZN    .   ZN  ? ? A HIS 387 A ZN    701 1_555 ? ? ? ? ? ? ? 2.002 ? ? 
metalc3 metalc ?    ? A GLU 375 OE1 ? ? ? 1_555 C ZN    .   ZN  ? ? A GLU 411 A ZN    701 1_555 ? ? ? ? ? ? ? 1.984 ? ? 
metalc4 metalc ?    ? C ZN  .   ZN  ? ? ? 1_555 I A1IJW .   O22 ? ? A ZN  701 A A1IJW 707 1_555 ? ? ? ? ? ? ? 2.050 ? ? 
metalc5 metalc ?    ? C ZN  .   ZN  ? ? ? 1_555 I A1IJW .   O21 ? ? A ZN  701 A A1IJW 707 1_555 ? ? ? ? ? ? ? 2.510 ? ? 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
covale ? ? 
metalc ? ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  NE2 ? A HIS   347 ? A HIS   383 ? 1_555 ZN ? C ZN . ? A ZN 701 ? 1_555 NE2 ? A HIS   351 ? A HIS   387 ? 1_555 109.7 ? 
2  NE2 ? A HIS   347 ? A HIS   383 ? 1_555 ZN ? C ZN . ? A ZN 701 ? 1_555 OE1 ? A GLU   375 ? A GLU   411 ? 1_555 95.0  ? 
3  NE2 ? A HIS   351 ? A HIS   387 ? 1_555 ZN ? C ZN . ? A ZN 701 ? 1_555 OE1 ? A GLU   375 ? A GLU   411 ? 1_555 103.4 ? 
4  NE2 ? A HIS   347 ? A HIS   383 ? 1_555 ZN ? C ZN . ? A ZN 701 ? 1_555 O22 ? I A1IJW .   ? A A1IJW 707 ? 1_555 113.9 ? 
5  NE2 ? A HIS   351 ? A HIS   387 ? 1_555 ZN ? C ZN . ? A ZN 701 ? 1_555 O22 ? I A1IJW .   ? A A1IJW 707 ? 1_555 126.8 ? 
6  OE1 ? A GLU   375 ? A GLU   411 ? 1_555 ZN ? C ZN . ? A ZN 701 ? 1_555 O22 ? I A1IJW .   ? A A1IJW 707 ? 1_555 101.7 ? 
7  NE2 ? A HIS   347 ? A HIS   383 ? 1_555 ZN ? C ZN . ? A ZN 701 ? 1_555 O21 ? I A1IJW .   ? A A1IJW 707 ? 1_555 91.2  ? 
8  NE2 ? A HIS   351 ? A HIS   387 ? 1_555 ZN ? C ZN . ? A ZN 701 ? 1_555 O21 ? I A1IJW .   ? A A1IJW 707 ? 1_555 92.1  ? 
9  OE1 ? A GLU   375 ? A GLU   411 ? 1_555 ZN ? C ZN . ? A ZN 701 ? 1_555 O21 ? I A1IJW .   ? A A1IJW 707 ? 1_555 160.2 ? 
10 O22 ? I A1IJW .   ? A A1IJW 707 ? 1_555 ZN ? C ZN . ? A ZN 701 ? 1_555 O21 ? I A1IJW .   ? A A1IJW 707 ? 1_555 58.7  ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 NAG B .   ? ASN A 73  ? NAG B 1   ? 1_555 ASN A 109 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
2 NAG J .   ? ASN A 36  ? NAG A 708 ? 1_555 ASN A 72  ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
3 CYS A 116 ? CYS A 122 ? CYS A 152 ? 1_555 CYS A 158 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
4 CYS A 316 ? CYS A 334 ? CYS A 352 ? 1_555 CYS A 370 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
5 CYS A 502 ? CYS A 514 ? CYS A 538 ? 1_555 CYS A 550 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          GLU 
_struct_mon_prot_cis.label_seq_id           126 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           GLU 
_struct_mon_prot_cis.auth_seq_id            162 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    127 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     163 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       0.36 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 2 ? 
AA2 ? 2 ? 
AA3 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA2 1 2 ? parallel      
AA3 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 THR A 114 ? CYS A 116 ? THR A 150 CYS A 152 
AA1 2 CYS A 122 ? GLN A 124 ? CYS A 158 GLN A 160 
AA2 1 ILE A 234 ? PRO A 235 ? ILE A 270 PRO A 271 
AA2 2 LEU A 459 ? CYS A 460 ? LEU A 495 CYS A 496 
AA3 1 SER A 319 ? ASP A 322 ? SER A 355 ASP A 358 
AA3 2 PHE A 329 ? LYS A 332 ? PHE A 365 LYS A 368 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N VAL A 115 ? N VAL A 151 O LEU A 123 ? O LEU A 159 
AA2 1 2 N ILE A 234 ? N ILE A 270 O CYS A 460 ? O CYS A 496 
AA3 1 2 N TRP A 321 ? N TRP A 357 O ARG A 330 ? O ARG A 366 
# 
_pdbx_entry_details.entry_id                   9GBM 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 O  A PRO 154 ? ? N  A GLY 156  ? ? 1.98 
2 1 CL A CL  706 ? ? O  A HOH 1069 ? ? 2.10 
3 1 O6 B NAG 1   ? ? O5 B FUC 4    ? ? 2.18 
# 
_pdbx_validate_rmsd_bond.id                        1 
_pdbx_validate_rmsd_bond.PDB_model_num             1 
_pdbx_validate_rmsd_bond.auth_atom_id_1            CG 
_pdbx_validate_rmsd_bond.auth_asym_id_1            A 
_pdbx_validate_rmsd_bond.auth_comp_id_1            HIS 
_pdbx_validate_rmsd_bond.auth_seq_id_1             383 
_pdbx_validate_rmsd_bond.PDB_ins_code_1            ? 
_pdbx_validate_rmsd_bond.label_alt_id_1            ? 
_pdbx_validate_rmsd_bond.auth_atom_id_2            CD2 
_pdbx_validate_rmsd_bond.auth_asym_id_2            A 
_pdbx_validate_rmsd_bond.auth_comp_id_2            HIS 
_pdbx_validate_rmsd_bond.auth_seq_id_2             383 
_pdbx_validate_rmsd_bond.PDB_ins_code_2            ? 
_pdbx_validate_rmsd_bond.label_alt_id_2            ? 
_pdbx_validate_rmsd_bond.bond_value                1.409 
_pdbx_validate_rmsd_bond.bond_target_value         1.354 
_pdbx_validate_rmsd_bond.bond_deviation            0.055 
_pdbx_validate_rmsd_bond.bond_standard_deviation   0.009 
_pdbx_validate_rmsd_bond.linker_flag               N 
# 
loop_
_pdbx_validate_rmsd_angle.id 
_pdbx_validate_rmsd_angle.PDB_model_num 
_pdbx_validate_rmsd_angle.auth_atom_id_1 
_pdbx_validate_rmsd_angle.auth_asym_id_1 
_pdbx_validate_rmsd_angle.auth_comp_id_1 
_pdbx_validate_rmsd_angle.auth_seq_id_1 
_pdbx_validate_rmsd_angle.PDB_ins_code_1 
_pdbx_validate_rmsd_angle.label_alt_id_1 
_pdbx_validate_rmsd_angle.auth_atom_id_2 
_pdbx_validate_rmsd_angle.auth_asym_id_2 
_pdbx_validate_rmsd_angle.auth_comp_id_2 
_pdbx_validate_rmsd_angle.auth_seq_id_2 
_pdbx_validate_rmsd_angle.PDB_ins_code_2 
_pdbx_validate_rmsd_angle.label_alt_id_2 
_pdbx_validate_rmsd_angle.auth_atom_id_3 
_pdbx_validate_rmsd_angle.auth_asym_id_3 
_pdbx_validate_rmsd_angle.auth_comp_id_3 
_pdbx_validate_rmsd_angle.auth_seq_id_3 
_pdbx_validate_rmsd_angle.PDB_ins_code_3 
_pdbx_validate_rmsd_angle.label_alt_id_3 
_pdbx_validate_rmsd_angle.angle_value 
_pdbx_validate_rmsd_angle.angle_target_value 
_pdbx_validate_rmsd_angle.angle_deviation 
_pdbx_validate_rmsd_angle.angle_standard_deviation 
_pdbx_validate_rmsd_angle.linker_flag 
1  1 CB A TYR 69  ? ? CG A TYR 69  ? ? CD2 A TYR 69  ? ? 117.15 121.00 -3.85  0.60 N 
2  1 CG A MET 86  ? ? SD A MET 86  ? ? CE  A MET 86  ? ? 115.51 100.20 15.31  1.60 N 
3  1 CB A LYS 137 ? ? CG A LYS 137 ? ? CD  A LYS 137 ? ? 129.33 111.60 17.73  2.60 N 
4  1 CD A ARG 173 ? ? NE A ARG 173 ? ? CZ  A ARG 173 ? ? 132.82 123.60 9.22   1.40 N 
5  1 NE A ARG 173 ? ? CZ A ARG 173 ? ? NH2 A ARG 173 ? ? 123.65 120.30 3.35   0.50 N 
6  1 N  A LYS 188 ? ? CA A LYS 188 ? ? CB  A LYS 188 ? ? 121.80 110.60 11.20  1.80 N 
7  1 NE A ARG 257 ? ? CZ A ARG 257 ? ? NH1 A ARG 257 ? ? 123.84 120.30 3.54   0.50 N 
8  1 NE A ARG 257 ? ? CZ A ARG 257 ? ? NH2 A ARG 257 ? ? 116.93 120.30 -3.37  0.50 N 
9  1 CA A THR 301 ? ? CB A THR 301 ? ? OG1 A THR 301 ? ? 95.87  109.00 -13.13 2.10 N 
10 1 CB A GLN 337 ? ? CA A GLN 337 ? ? C   A GLN 337 ? ? 98.15  110.40 -12.25 2.00 N 
11 1 NE A ARG 501 ? ? CZ A ARG 501 ? ? NH1 A ARG 501 ? ? 123.43 120.30 3.13   0.50 N 
12 1 NE A ARG 501 ? ? CZ A ARG 501 ? ? NH2 A ARG 501 ? ? 115.62 120.30 -4.68  0.50 N 
13 1 CG A ARG 561 ? ? CD A ARG 561 ? ? NE  A ARG 561 ? ? 93.29  111.80 -18.51 2.10 N 
14 1 CA A THR 605 ? ? CB A THR 605 ? ? OG1 A THR 605 ? ? 94.78  109.00 -14.22 2.10 N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASN A 72  ? ? -176.60 76.22   
2 1 GLU A 123 ? ? 42.71   -135.06 
3 1 LYS A 363 ? ? -137.73 -31.37  
4 1 ASN A 431 ? ? 71.71   34.99   
# 
loop_
_pdbx_validate_planes.id 
_pdbx_validate_planes.PDB_model_num 
_pdbx_validate_planes.auth_comp_id 
_pdbx_validate_planes.auth_asym_id 
_pdbx_validate_planes.auth_seq_id 
_pdbx_validate_planes.PDB_ins_code 
_pdbx_validate_planes.label_alt_id 
_pdbx_validate_planes.rmsd 
_pdbx_validate_planes.type 
1 1 ARG A 313 ? ? 0.120 'SIDE CHAIN' 
2 1 ARG A 470 ? ? 0.086 'SIDE CHAIN' 
3 1 ARG A 489 ? ? 0.091 'SIDE CHAIN' 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A LEU 37  ? A LEU 1   
2  1 Y 1 A VAL 38  ? A VAL 2   
3  1 Y 1 A THR 39  ? A THR 3   
4  1 Y 1 A ASP 40  ? A ASP 4   
5  1 Y 1 A GLN 155 ? A GLN 119 
6  1 Y 1 A SER 435 ? A SER 399 
7  1 Y 1 A GLU 436 ? A GLU 400 
8  1 Y 1 A GLY 437 ? A GLY 401 
9  1 Y 1 A GLY 438 ? A GLY 402 
10 1 Y 1 A PRO 617 ? A PRO 581 
11 1 Y 1 A GLN 618 ? A GLN 582 
12 1 Y 1 A TYR 619 ? A TYR 583 
13 1 Y 1 A ASN 620 ? A ASN 584 
14 1 Y 1 A TRP 621 ? A TRP 585 
15 1 Y 1 A THR 622 ? A THR 586 
16 1 Y 1 A PRO 623 ? A PRO 587 
17 1 Y 1 A ASN 624 ? A ASN 588 
18 1 Y 1 A SER 625 ? A SER 589 
19 1 Y 1 A ALA 626 ? A ALA 590 
20 1 Y 1 A ARG 627 ? A ARG 591 
21 1 Y 1 A SER 628 ? A SER 592 
22 1 Y 1 A GLU 629 ? A GLU 593 
23 1 Y 1 A GLY 630 ? A GLY 594 
24 1 Y 1 A PRO 631 ? A PRO 595 
25 1 Y 1 A LEU 632 ? A LEU 596 
26 1 Y 1 A PRO 633 ? A PRO 597 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1IJW C12  C  Y N 1   
A1IJW O01  O  N N 2   
A1IJW C02  C  N N 3   
A1IJW C03  C  N S 4   
A1IJW N04  N  N N 5   
A1IJW C05  C  N S 6   
A1IJW C06  C  N S 7   
A1IJW C07  C  N N 8   
A1IJW C08  C  N N 9   
A1IJW C09  C  N N 10  
A1IJW N10  N  N N 11  
A1IJW C11  C  N N 12  
A1IJW C13  C  Y N 13  
A1IJW C14  C  Y N 14  
A1IJW C15  C  Y N 15  
A1IJW N16  N  N N 16  
A1IJW C17  C  Y N 17  
A1IJW C18  C  Y N 18  
A1IJW O19  O  N N 19  
A1IJW C20  C  N N 20  
A1IJW O21  O  N N 21  
A1IJW O22  O  N N 22  
A1IJW C23  C  N N 23  
A1IJW N24  N  N N 24  
A1IJW C25  C  N N 25  
A1IJW C26  C  N N 26  
A1IJW C27  C  N N 27  
A1IJW C28  C  N S 28  
A1IJW C29  C  N N 29  
A1IJW O30  O  N N 30  
A1IJW O31  O  N N 31  
A1IJW H1   H  N N 32  
A1IJW H2   H  N N 33  
A1IJW H4   H  N N 34  
A1IJW H5   H  N N 35  
A1IJW H6   H  N N 36  
A1IJW H7   H  N N 37  
A1IJW H8   H  N N 38  
A1IJW H9   H  N N 39  
A1IJW H10  H  N N 40  
A1IJW H11  H  N N 41  
A1IJW H12  H  N N 42  
A1IJW H13  H  N N 43  
A1IJW H14  H  N N 44  
A1IJW H15  H  N N 45  
A1IJW H16  H  N N 46  
A1IJW H17  H  N N 47  
A1IJW H18  H  N N 48  
A1IJW H19  H  N N 49  
A1IJW H20  H  N N 50  
A1IJW H21  H  N N 51  
A1IJW H22  H  N N 52  
A1IJW H23  H  N N 53  
A1IJW H24  H  N N 54  
A1IJW H25  H  N N 55  
A1IJW H26  H  N N 56  
A1IJW H27  H  N N 57  
A1IJW H28  H  N N 58  
A1IJW H29  H  N N 59  
ALA   N    N  N N 60  
ALA   CA   C  N S 61  
ALA   C    C  N N 62  
ALA   O    O  N N 63  
ALA   CB   C  N N 64  
ALA   OXT  O  N N 65  
ALA   H    H  N N 66  
ALA   H2   H  N N 67  
ALA   HA   H  N N 68  
ALA   HB1  H  N N 69  
ALA   HB2  H  N N 70  
ALA   HB3  H  N N 71  
ALA   HXT  H  N N 72  
ARG   N    N  N N 73  
ARG   CA   C  N S 74  
ARG   C    C  N N 75  
ARG   O    O  N N 76  
ARG   CB   C  N N 77  
ARG   CG   C  N N 78  
ARG   CD   C  N N 79  
ARG   NE   N  N N 80  
ARG   CZ   C  N N 81  
ARG   NH1  N  N N 82  
ARG   NH2  N  N N 83  
ARG   OXT  O  N N 84  
ARG   H    H  N N 85  
ARG   H2   H  N N 86  
ARG   HA   H  N N 87  
ARG   HB2  H  N N 88  
ARG   HB3  H  N N 89  
ARG   HG2  H  N N 90  
ARG   HG3  H  N N 91  
ARG   HD2  H  N N 92  
ARG   HD3  H  N N 93  
ARG   HE   H  N N 94  
ARG   HH11 H  N N 95  
ARG   HH12 H  N N 96  
ARG   HH21 H  N N 97  
ARG   HH22 H  N N 98  
ARG   HXT  H  N N 99  
ASN   N    N  N N 100 
ASN   CA   C  N S 101 
ASN   C    C  N N 102 
ASN   O    O  N N 103 
ASN   CB   C  N N 104 
ASN   CG   C  N N 105 
ASN   OD1  O  N N 106 
ASN   ND2  N  N N 107 
ASN   OXT  O  N N 108 
ASN   H    H  N N 109 
ASN   H2   H  N N 110 
ASN   HA   H  N N 111 
ASN   HB2  H  N N 112 
ASN   HB3  H  N N 113 
ASN   HD21 H  N N 114 
ASN   HD22 H  N N 115 
ASN   HXT  H  N N 116 
ASP   N    N  N N 117 
ASP   CA   C  N S 118 
ASP   C    C  N N 119 
ASP   O    O  N N 120 
ASP   CB   C  N N 121 
ASP   CG   C  N N 122 
ASP   OD1  O  N N 123 
ASP   OD2  O  N N 124 
ASP   OXT  O  N N 125 
ASP   H    H  N N 126 
ASP   H2   H  N N 127 
ASP   HA   H  N N 128 
ASP   HB2  H  N N 129 
ASP   HB3  H  N N 130 
ASP   HD2  H  N N 131 
ASP   HXT  H  N N 132 
BMA   C1   C  N R 133 
BMA   C2   C  N S 134 
BMA   C3   C  N S 135 
BMA   C4   C  N S 136 
BMA   C5   C  N R 137 
BMA   C6   C  N N 138 
BMA   O1   O  N N 139 
BMA   O2   O  N N 140 
BMA   O3   O  N N 141 
BMA   O4   O  N N 142 
BMA   O5   O  N N 143 
BMA   O6   O  N N 144 
BMA   H1   H  N N 145 
BMA   H2   H  N N 146 
BMA   H3   H  N N 147 
BMA   H4   H  N N 148 
BMA   H5   H  N N 149 
BMA   H61  H  N N 150 
BMA   H62  H  N N 151 
BMA   HO1  H  N N 152 
BMA   HO2  H  N N 153 
BMA   HO3  H  N N 154 
BMA   HO4  H  N N 155 
BMA   HO6  H  N N 156 
BO3   B    B  N N 157 
BO3   O1   O  N N 158 
BO3   O2   O  N N 159 
BO3   O3   O  N N 160 
BO3   HO1  H  N N 161 
BO3   HO2  H  N N 162 
BO3   HO3  H  N N 163 
CL    CL   CL N N 164 
CYS   N    N  N N 165 
CYS   CA   C  N R 166 
CYS   C    C  N N 167 
CYS   O    O  N N 168 
CYS   CB   C  N N 169 
CYS   SG   S  N N 170 
CYS   OXT  O  N N 171 
CYS   H    H  N N 172 
CYS   H2   H  N N 173 
CYS   HA   H  N N 174 
CYS   HB2  H  N N 175 
CYS   HB3  H  N N 176 
CYS   HG   H  N N 177 
CYS   HXT  H  N N 178 
EDO   C1   C  N N 179 
EDO   O1   O  N N 180 
EDO   C2   C  N N 181 
EDO   O2   O  N N 182 
EDO   H11  H  N N 183 
EDO   H12  H  N N 184 
EDO   HO1  H  N N 185 
EDO   H21  H  N N 186 
EDO   H22  H  N N 187 
EDO   HO2  H  N N 188 
FUC   C1   C  N R 189 
FUC   C2   C  N S 190 
FUC   C3   C  N R 191 
FUC   C4   C  N S 192 
FUC   C5   C  N S 193 
FUC   C6   C  N N 194 
FUC   O1   O  N N 195 
FUC   O2   O  N N 196 
FUC   O3   O  N N 197 
FUC   O4   O  N N 198 
FUC   O5   O  N N 199 
FUC   H1   H  N N 200 
FUC   H2   H  N N 201 
FUC   H3   H  N N 202 
FUC   H4   H  N N 203 
FUC   H5   H  N N 204 
FUC   H61  H  N N 205 
FUC   H62  H  N N 206 
FUC   H63  H  N N 207 
FUC   HO1  H  N N 208 
FUC   HO2  H  N N 209 
FUC   HO3  H  N N 210 
FUC   HO4  H  N N 211 
GLN   N    N  N N 212 
GLN   CA   C  N S 213 
GLN   C    C  N N 214 
GLN   O    O  N N 215 
GLN   CB   C  N N 216 
GLN   CG   C  N N 217 
GLN   CD   C  N N 218 
GLN   OE1  O  N N 219 
GLN   NE2  N  N N 220 
GLN   OXT  O  N N 221 
GLN   H    H  N N 222 
GLN   H2   H  N N 223 
GLN   HA   H  N N 224 
GLN   HB2  H  N N 225 
GLN   HB3  H  N N 226 
GLN   HG2  H  N N 227 
GLN   HG3  H  N N 228 
GLN   HE21 H  N N 229 
GLN   HE22 H  N N 230 
GLN   HXT  H  N N 231 
GLU   N    N  N N 232 
GLU   CA   C  N S 233 
GLU   C    C  N N 234 
GLU   O    O  N N 235 
GLU   CB   C  N N 236 
GLU   CG   C  N N 237 
GLU   CD   C  N N 238 
GLU   OE1  O  N N 239 
GLU   OE2  O  N N 240 
GLU   OXT  O  N N 241 
GLU   H    H  N N 242 
GLU   H2   H  N N 243 
GLU   HA   H  N N 244 
GLU   HB2  H  N N 245 
GLU   HB3  H  N N 246 
GLU   HG2  H  N N 247 
GLU   HG3  H  N N 248 
GLU   HE2  H  N N 249 
GLU   HXT  H  N N 250 
GLY   N    N  N N 251 
GLY   CA   C  N N 252 
GLY   C    C  N N 253 
GLY   O    O  N N 254 
GLY   OXT  O  N N 255 
GLY   H    H  N N 256 
GLY   H2   H  N N 257 
GLY   HA2  H  N N 258 
GLY   HA3  H  N N 259 
GLY   HXT  H  N N 260 
HIS   N    N  N N 261 
HIS   CA   C  N S 262 
HIS   C    C  N N 263 
HIS   O    O  N N 264 
HIS   CB   C  N N 265 
HIS   CG   C  Y N 266 
HIS   ND1  N  Y N 267 
HIS   CD2  C  Y N 268 
HIS   CE1  C  Y N 269 
HIS   NE2  N  Y N 270 
HIS   OXT  O  N N 271 
HIS   H    H  N N 272 
HIS   H2   H  N N 273 
HIS   HA   H  N N 274 
HIS   HB2  H  N N 275 
HIS   HB3  H  N N 276 
HIS   HD1  H  N N 277 
HIS   HD2  H  N N 278 
HIS   HE1  H  N N 279 
HIS   HE2  H  N N 280 
HIS   HXT  H  N N 281 
HOH   O    O  N N 282 
HOH   H1   H  N N 283 
HOH   H2   H  N N 284 
ILE   N    N  N N 285 
ILE   CA   C  N S 286 
ILE   C    C  N N 287 
ILE   O    O  N N 288 
ILE   CB   C  N S 289 
ILE   CG1  C  N N 290 
ILE   CG2  C  N N 291 
ILE   CD1  C  N N 292 
ILE   OXT  O  N N 293 
ILE   H    H  N N 294 
ILE   H2   H  N N 295 
ILE   HA   H  N N 296 
ILE   HB   H  N N 297 
ILE   HG12 H  N N 298 
ILE   HG13 H  N N 299 
ILE   HG21 H  N N 300 
ILE   HG22 H  N N 301 
ILE   HG23 H  N N 302 
ILE   HD11 H  N N 303 
ILE   HD12 H  N N 304 
ILE   HD13 H  N N 305 
ILE   HXT  H  N N 306 
LEU   N    N  N N 307 
LEU   CA   C  N S 308 
LEU   C    C  N N 309 
LEU   O    O  N N 310 
LEU   CB   C  N N 311 
LEU   CG   C  N N 312 
LEU   CD1  C  N N 313 
LEU   CD2  C  N N 314 
LEU   OXT  O  N N 315 
LEU   H    H  N N 316 
LEU   H2   H  N N 317 
LEU   HA   H  N N 318 
LEU   HB2  H  N N 319 
LEU   HB3  H  N N 320 
LEU   HG   H  N N 321 
LEU   HD11 H  N N 322 
LEU   HD12 H  N N 323 
LEU   HD13 H  N N 324 
LEU   HD21 H  N N 325 
LEU   HD22 H  N N 326 
LEU   HD23 H  N N 327 
LEU   HXT  H  N N 328 
LYS   N    N  N N 329 
LYS   CA   C  N S 330 
LYS   C    C  N N 331 
LYS   O    O  N N 332 
LYS   CB   C  N N 333 
LYS   CG   C  N N 334 
LYS   CD   C  N N 335 
LYS   CE   C  N N 336 
LYS   NZ   N  N N 337 
LYS   OXT  O  N N 338 
LYS   H    H  N N 339 
LYS   H2   H  N N 340 
LYS   HA   H  N N 341 
LYS   HB2  H  N N 342 
LYS   HB3  H  N N 343 
LYS   HG2  H  N N 344 
LYS   HG3  H  N N 345 
LYS   HD2  H  N N 346 
LYS   HD3  H  N N 347 
LYS   HE2  H  N N 348 
LYS   HE3  H  N N 349 
LYS   HZ1  H  N N 350 
LYS   HZ2  H  N N 351 
LYS   HZ3  H  N N 352 
LYS   HXT  H  N N 353 
MET   N    N  N N 354 
MET   CA   C  N S 355 
MET   C    C  N N 356 
MET   O    O  N N 357 
MET   CB   C  N N 358 
MET   CG   C  N N 359 
MET   SD   S  N N 360 
MET   CE   C  N N 361 
MET   OXT  O  N N 362 
MET   H    H  N N 363 
MET   H2   H  N N 364 
MET   HA   H  N N 365 
MET   HB2  H  N N 366 
MET   HB3  H  N N 367 
MET   HG2  H  N N 368 
MET   HG3  H  N N 369 
MET   HE1  H  N N 370 
MET   HE2  H  N N 371 
MET   HE3  H  N N 372 
MET   HXT  H  N N 373 
NAG   C1   C  N R 374 
NAG   C2   C  N R 375 
NAG   C3   C  N R 376 
NAG   C4   C  N S 377 
NAG   C5   C  N R 378 
NAG   C6   C  N N 379 
NAG   C7   C  N N 380 
NAG   C8   C  N N 381 
NAG   N2   N  N N 382 
NAG   O1   O  N N 383 
NAG   O3   O  N N 384 
NAG   O4   O  N N 385 
NAG   O5   O  N N 386 
NAG   O6   O  N N 387 
NAG   O7   O  N N 388 
NAG   H1   H  N N 389 
NAG   H2   H  N N 390 
NAG   H3   H  N N 391 
NAG   H4   H  N N 392 
NAG   H5   H  N N 393 
NAG   H61  H  N N 394 
NAG   H62  H  N N 395 
NAG   H81  H  N N 396 
NAG   H82  H  N N 397 
NAG   H83  H  N N 398 
NAG   HN2  H  N N 399 
NAG   HO1  H  N N 400 
NAG   HO3  H  N N 401 
NAG   HO4  H  N N 402 
NAG   HO6  H  N N 403 
PEG   C1   C  N N 404 
PEG   O1   O  N N 405 
PEG   C2   C  N N 406 
PEG   O2   O  N N 407 
PEG   C3   C  N N 408 
PEG   C4   C  N N 409 
PEG   O4   O  N N 410 
PEG   H11  H  N N 411 
PEG   H12  H  N N 412 
PEG   HO1  H  N N 413 
PEG   H21  H  N N 414 
PEG   H22  H  N N 415 
PEG   H31  H  N N 416 
PEG   H32  H  N N 417 
PEG   H41  H  N N 418 
PEG   H42  H  N N 419 
PEG   HO4  H  N N 420 
PHE   N    N  N N 421 
PHE   CA   C  N S 422 
PHE   C    C  N N 423 
PHE   O    O  N N 424 
PHE   CB   C  N N 425 
PHE   CG   C  Y N 426 
PHE   CD1  C  Y N 427 
PHE   CD2  C  Y N 428 
PHE   CE1  C  Y N 429 
PHE   CE2  C  Y N 430 
PHE   CZ   C  Y N 431 
PHE   OXT  O  N N 432 
PHE   H    H  N N 433 
PHE   H2   H  N N 434 
PHE   HA   H  N N 435 
PHE   HB2  H  N N 436 
PHE   HB3  H  N N 437 
PHE   HD1  H  N N 438 
PHE   HD2  H  N N 439 
PHE   HE1  H  N N 440 
PHE   HE2  H  N N 441 
PHE   HZ   H  N N 442 
PHE   HXT  H  N N 443 
PRO   N    N  N N 444 
PRO   CA   C  N S 445 
PRO   C    C  N N 446 
PRO   O    O  N N 447 
PRO   CB   C  N N 448 
PRO   CG   C  N N 449 
PRO   CD   C  N N 450 
PRO   OXT  O  N N 451 
PRO   H    H  N N 452 
PRO   HA   H  N N 453 
PRO   HB2  H  N N 454 
PRO   HB3  H  N N 455 
PRO   HG2  H  N N 456 
PRO   HG3  H  N N 457 
PRO   HD2  H  N N 458 
PRO   HD3  H  N N 459 
PRO   HXT  H  N N 460 
SER   N    N  N N 461 
SER   CA   C  N S 462 
SER   C    C  N N 463 
SER   O    O  N N 464 
SER   CB   C  N N 465 
SER   OG   O  N N 466 
SER   OXT  O  N N 467 
SER   H    H  N N 468 
SER   H2   H  N N 469 
SER   HA   H  N N 470 
SER   HB2  H  N N 471 
SER   HB3  H  N N 472 
SER   HG   H  N N 473 
SER   HXT  H  N N 474 
THR   N    N  N N 475 
THR   CA   C  N S 476 
THR   C    C  N N 477 
THR   O    O  N N 478 
THR   CB   C  N R 479 
THR   OG1  O  N N 480 
THR   CG2  C  N N 481 
THR   OXT  O  N N 482 
THR   H    H  N N 483 
THR   H2   H  N N 484 
THR   HA   H  N N 485 
THR   HB   H  N N 486 
THR   HG1  H  N N 487 
THR   HG21 H  N N 488 
THR   HG22 H  N N 489 
THR   HG23 H  N N 490 
THR   HXT  H  N N 491 
TRP   N    N  N N 492 
TRP   CA   C  N S 493 
TRP   C    C  N N 494 
TRP   O    O  N N 495 
TRP   CB   C  N N 496 
TRP   CG   C  Y N 497 
TRP   CD1  C  Y N 498 
TRP   CD2  C  Y N 499 
TRP   NE1  N  Y N 500 
TRP   CE2  C  Y N 501 
TRP   CE3  C  Y N 502 
TRP   CZ2  C  Y N 503 
TRP   CZ3  C  Y N 504 
TRP   CH2  C  Y N 505 
TRP   OXT  O  N N 506 
TRP   H    H  N N 507 
TRP   H2   H  N N 508 
TRP   HA   H  N N 509 
TRP   HB2  H  N N 510 
TRP   HB3  H  N N 511 
TRP   HD1  H  N N 512 
TRP   HE1  H  N N 513 
TRP   HE3  H  N N 514 
TRP   HZ2  H  N N 515 
TRP   HZ3  H  N N 516 
TRP   HH2  H  N N 517 
TRP   HXT  H  N N 518 
TYR   N    N  N N 519 
TYR   CA   C  N S 520 
TYR   C    C  N N 521 
TYR   O    O  N N 522 
TYR   CB   C  N N 523 
TYR   CG   C  Y N 524 
TYR   CD1  C  Y N 525 
TYR   CD2  C  Y N 526 
TYR   CE1  C  Y N 527 
TYR   CE2  C  Y N 528 
TYR   CZ   C  Y N 529 
TYR   OH   O  N N 530 
TYR   OXT  O  N N 531 
TYR   H    H  N N 532 
TYR   H2   H  N N 533 
TYR   HA   H  N N 534 
TYR   HB2  H  N N 535 
TYR   HB3  H  N N 536 
TYR   HD1  H  N N 537 
TYR   HD2  H  N N 538 
TYR   HE1  H  N N 539 
TYR   HE2  H  N N 540 
TYR   HH   H  N N 541 
TYR   HXT  H  N N 542 
VAL   N    N  N N 543 
VAL   CA   C  N S 544 
VAL   C    C  N N 545 
VAL   O    O  N N 546 
VAL   CB   C  N N 547 
VAL   CG1  C  N N 548 
VAL   CG2  C  N N 549 
VAL   OXT  O  N N 550 
VAL   H    H  N N 551 
VAL   H2   H  N N 552 
VAL   HA   H  N N 553 
VAL   HB   H  N N 554 
VAL   HG11 H  N N 555 
VAL   HG12 H  N N 556 
VAL   HG13 H  N N 557 
VAL   HG21 H  N N 558 
VAL   HG22 H  N N 559 
VAL   HG23 H  N N 560 
VAL   HXT  H  N N 561 
ZN    ZN   ZN N N 562 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1IJW O30 C29  doub N N 1   
A1IJW C29 O31  sing N N 2   
A1IJW C29 C28  sing N N 3   
A1IJW C27 C28  sing N N 4   
A1IJW C27 C26  sing N N 5   
A1IJW C28 N24  sing N N 6   
A1IJW C26 C25  sing N N 7   
A1IJW N24 C25  sing N N 8   
A1IJW N24 C02  sing N N 9   
A1IJW O01 C02  doub N N 10  
A1IJW C02 C03  sing N N 11  
A1IJW C23 C03  sing N N 12  
A1IJW C03 N04  sing N N 13  
A1IJW N04 C05  sing N N 14  
A1IJW O22 C20  doub N N 15  
A1IJW C05 C20  sing N N 16  
A1IJW C05 C06  sing N N 17  
A1IJW C08 C07  sing N N 18  
A1IJW C08 C09  sing N N 19  
A1IJW C20 O21  sing N N 20  
A1IJW C07 C06  sing N N 21  
A1IJW C09 N10  sing N N 22  
A1IJW C06 N10  sing N N 23  
A1IJW N10 C11  sing N N 24  
A1IJW C18 C17  doub Y N 25  
A1IJW C18 C12  sing Y N 26  
A1IJW C11 O19  doub N N 27  
A1IJW C11 C12  sing N N 28  
A1IJW C17 C15  sing Y N 29  
A1IJW C12 C13  doub Y N 30  
A1IJW C15 N16  sing N N 31  
A1IJW C15 C14  doub Y N 32  
A1IJW C13 C14  sing Y N 33  
A1IJW C03 H1   sing N N 34  
A1IJW N04 H2   sing N N 35  
A1IJW C05 H4   sing N N 36  
A1IJW C06 H5   sing N N 37  
A1IJW C07 H6   sing N N 38  
A1IJW C07 H7   sing N N 39  
A1IJW C08 H8   sing N N 40  
A1IJW C08 H9   sing N N 41  
A1IJW C09 H10  sing N N 42  
A1IJW C09 H11  sing N N 43  
A1IJW C13 H12  sing N N 44  
A1IJW C14 H13  sing N N 45  
A1IJW N16 H14  sing N N 46  
A1IJW N16 H15  sing N N 47  
A1IJW C17 H16  sing N N 48  
A1IJW C18 H17  sing N N 49  
A1IJW O21 H18  sing N N 50  
A1IJW C23 H19  sing N N 51  
A1IJW C23 H20  sing N N 52  
A1IJW C23 H21  sing N N 53  
A1IJW C25 H22  sing N N 54  
A1IJW C25 H23  sing N N 55  
A1IJW C26 H24  sing N N 56  
A1IJW C26 H25  sing N N 57  
A1IJW C27 H26  sing N N 58  
A1IJW C27 H27  sing N N 59  
A1IJW C28 H28  sing N N 60  
A1IJW O31 H29  sing N N 61  
ALA   N   CA   sing N N 62  
ALA   N   H    sing N N 63  
ALA   N   H2   sing N N 64  
ALA   CA  C    sing N N 65  
ALA   CA  CB   sing N N 66  
ALA   CA  HA   sing N N 67  
ALA   C   O    doub N N 68  
ALA   C   OXT  sing N N 69  
ALA   CB  HB1  sing N N 70  
ALA   CB  HB2  sing N N 71  
ALA   CB  HB3  sing N N 72  
ALA   OXT HXT  sing N N 73  
ARG   N   CA   sing N N 74  
ARG   N   H    sing N N 75  
ARG   N   H2   sing N N 76  
ARG   CA  C    sing N N 77  
ARG   CA  CB   sing N N 78  
ARG   CA  HA   sing N N 79  
ARG   C   O    doub N N 80  
ARG   C   OXT  sing N N 81  
ARG   CB  CG   sing N N 82  
ARG   CB  HB2  sing N N 83  
ARG   CB  HB3  sing N N 84  
ARG   CG  CD   sing N N 85  
ARG   CG  HG2  sing N N 86  
ARG   CG  HG3  sing N N 87  
ARG   CD  NE   sing N N 88  
ARG   CD  HD2  sing N N 89  
ARG   CD  HD3  sing N N 90  
ARG   NE  CZ   sing N N 91  
ARG   NE  HE   sing N N 92  
ARG   CZ  NH1  sing N N 93  
ARG   CZ  NH2  doub N N 94  
ARG   NH1 HH11 sing N N 95  
ARG   NH1 HH12 sing N N 96  
ARG   NH2 HH21 sing N N 97  
ARG   NH2 HH22 sing N N 98  
ARG   OXT HXT  sing N N 99  
ASN   N   CA   sing N N 100 
ASN   N   H    sing N N 101 
ASN   N   H2   sing N N 102 
ASN   CA  C    sing N N 103 
ASN   CA  CB   sing N N 104 
ASN   CA  HA   sing N N 105 
ASN   C   O    doub N N 106 
ASN   C   OXT  sing N N 107 
ASN   CB  CG   sing N N 108 
ASN   CB  HB2  sing N N 109 
ASN   CB  HB3  sing N N 110 
ASN   CG  OD1  doub N N 111 
ASN   CG  ND2  sing N N 112 
ASN   ND2 HD21 sing N N 113 
ASN   ND2 HD22 sing N N 114 
ASN   OXT HXT  sing N N 115 
ASP   N   CA   sing N N 116 
ASP   N   H    sing N N 117 
ASP   N   H2   sing N N 118 
ASP   CA  C    sing N N 119 
ASP   CA  CB   sing N N 120 
ASP   CA  HA   sing N N 121 
ASP   C   O    doub N N 122 
ASP   C   OXT  sing N N 123 
ASP   CB  CG   sing N N 124 
ASP   CB  HB2  sing N N 125 
ASP   CB  HB3  sing N N 126 
ASP   CG  OD1  doub N N 127 
ASP   CG  OD2  sing N N 128 
ASP   OD2 HD2  sing N N 129 
ASP   OXT HXT  sing N N 130 
BMA   C1  C2   sing N N 131 
BMA   C1  O1   sing N N 132 
BMA   C1  O5   sing N N 133 
BMA   C1  H1   sing N N 134 
BMA   C2  C3   sing N N 135 
BMA   C2  O2   sing N N 136 
BMA   C2  H2   sing N N 137 
BMA   C3  C4   sing N N 138 
BMA   C3  O3   sing N N 139 
BMA   C3  H3   sing N N 140 
BMA   C4  C5   sing N N 141 
BMA   C4  O4   sing N N 142 
BMA   C4  H4   sing N N 143 
BMA   C5  C6   sing N N 144 
BMA   C5  O5   sing N N 145 
BMA   C5  H5   sing N N 146 
BMA   C6  O6   sing N N 147 
BMA   C6  H61  sing N N 148 
BMA   C6  H62  sing N N 149 
BMA   O1  HO1  sing N N 150 
BMA   O2  HO2  sing N N 151 
BMA   O3  HO3  sing N N 152 
BMA   O4  HO4  sing N N 153 
BMA   O6  HO6  sing N N 154 
BO3   B   O1   sing N N 155 
BO3   B   O2   sing N N 156 
BO3   B   O3   sing N N 157 
BO3   O1  HO1  sing N N 158 
BO3   O2  HO2  sing N N 159 
BO3   O3  HO3  sing N N 160 
CYS   N   CA   sing N N 161 
CYS   N   H    sing N N 162 
CYS   N   H2   sing N N 163 
CYS   CA  C    sing N N 164 
CYS   CA  CB   sing N N 165 
CYS   CA  HA   sing N N 166 
CYS   C   O    doub N N 167 
CYS   C   OXT  sing N N 168 
CYS   CB  SG   sing N N 169 
CYS   CB  HB2  sing N N 170 
CYS   CB  HB3  sing N N 171 
CYS   SG  HG   sing N N 172 
CYS   OXT HXT  sing N N 173 
EDO   C1  O1   sing N N 174 
EDO   C1  C2   sing N N 175 
EDO   C1  H11  sing N N 176 
EDO   C1  H12  sing N N 177 
EDO   O1  HO1  sing N N 178 
EDO   C2  O2   sing N N 179 
EDO   C2  H21  sing N N 180 
EDO   C2  H22  sing N N 181 
EDO   O2  HO2  sing N N 182 
FUC   C1  C2   sing N N 183 
FUC   C1  O1   sing N N 184 
FUC   C1  O5   sing N N 185 
FUC   C1  H1   sing N N 186 
FUC   C2  C3   sing N N 187 
FUC   C2  O2   sing N N 188 
FUC   C2  H2   sing N N 189 
FUC   C3  C4   sing N N 190 
FUC   C3  O3   sing N N 191 
FUC   C3  H3   sing N N 192 
FUC   C4  C5   sing N N 193 
FUC   C4  O4   sing N N 194 
FUC   C4  H4   sing N N 195 
FUC   C5  C6   sing N N 196 
FUC   C5  O5   sing N N 197 
FUC   C5  H5   sing N N 198 
FUC   C6  H61  sing N N 199 
FUC   C6  H62  sing N N 200 
FUC   C6  H63  sing N N 201 
FUC   O1  HO1  sing N N 202 
FUC   O2  HO2  sing N N 203 
FUC   O3  HO3  sing N N 204 
FUC   O4  HO4  sing N N 205 
GLN   N   CA   sing N N 206 
GLN   N   H    sing N N 207 
GLN   N   H2   sing N N 208 
GLN   CA  C    sing N N 209 
GLN   CA  CB   sing N N 210 
GLN   CA  HA   sing N N 211 
GLN   C   O    doub N N 212 
GLN   C   OXT  sing N N 213 
GLN   CB  CG   sing N N 214 
GLN   CB  HB2  sing N N 215 
GLN   CB  HB3  sing N N 216 
GLN   CG  CD   sing N N 217 
GLN   CG  HG2  sing N N 218 
GLN   CG  HG3  sing N N 219 
GLN   CD  OE1  doub N N 220 
GLN   CD  NE2  sing N N 221 
GLN   NE2 HE21 sing N N 222 
GLN   NE2 HE22 sing N N 223 
GLN   OXT HXT  sing N N 224 
GLU   N   CA   sing N N 225 
GLU   N   H    sing N N 226 
GLU   N   H2   sing N N 227 
GLU   CA  C    sing N N 228 
GLU   CA  CB   sing N N 229 
GLU   CA  HA   sing N N 230 
GLU   C   O    doub N N 231 
GLU   C   OXT  sing N N 232 
GLU   CB  CG   sing N N 233 
GLU   CB  HB2  sing N N 234 
GLU   CB  HB3  sing N N 235 
GLU   CG  CD   sing N N 236 
GLU   CG  HG2  sing N N 237 
GLU   CG  HG3  sing N N 238 
GLU   CD  OE1  doub N N 239 
GLU   CD  OE2  sing N N 240 
GLU   OE2 HE2  sing N N 241 
GLU   OXT HXT  sing N N 242 
GLY   N   CA   sing N N 243 
GLY   N   H    sing N N 244 
GLY   N   H2   sing N N 245 
GLY   CA  C    sing N N 246 
GLY   CA  HA2  sing N N 247 
GLY   CA  HA3  sing N N 248 
GLY   C   O    doub N N 249 
GLY   C   OXT  sing N N 250 
GLY   OXT HXT  sing N N 251 
HIS   N   CA   sing N N 252 
HIS   N   H    sing N N 253 
HIS   N   H2   sing N N 254 
HIS   CA  C    sing N N 255 
HIS   CA  CB   sing N N 256 
HIS   CA  HA   sing N N 257 
HIS   C   O    doub N N 258 
HIS   C   OXT  sing N N 259 
HIS   CB  CG   sing N N 260 
HIS   CB  HB2  sing N N 261 
HIS   CB  HB3  sing N N 262 
HIS   CG  ND1  sing Y N 263 
HIS   CG  CD2  doub Y N 264 
HIS   ND1 CE1  doub Y N 265 
HIS   ND1 HD1  sing N N 266 
HIS   CD2 NE2  sing Y N 267 
HIS   CD2 HD2  sing N N 268 
HIS   CE1 NE2  sing Y N 269 
HIS   CE1 HE1  sing N N 270 
HIS   NE2 HE2  sing N N 271 
HIS   OXT HXT  sing N N 272 
HOH   O   H1   sing N N 273 
HOH   O   H2   sing N N 274 
ILE   N   CA   sing N N 275 
ILE   N   H    sing N N 276 
ILE   N   H2   sing N N 277 
ILE   CA  C    sing N N 278 
ILE   CA  CB   sing N N 279 
ILE   CA  HA   sing N N 280 
ILE   C   O    doub N N 281 
ILE   C   OXT  sing N N 282 
ILE   CB  CG1  sing N N 283 
ILE   CB  CG2  sing N N 284 
ILE   CB  HB   sing N N 285 
ILE   CG1 CD1  sing N N 286 
ILE   CG1 HG12 sing N N 287 
ILE   CG1 HG13 sing N N 288 
ILE   CG2 HG21 sing N N 289 
ILE   CG2 HG22 sing N N 290 
ILE   CG2 HG23 sing N N 291 
ILE   CD1 HD11 sing N N 292 
ILE   CD1 HD12 sing N N 293 
ILE   CD1 HD13 sing N N 294 
ILE   OXT HXT  sing N N 295 
LEU   N   CA   sing N N 296 
LEU   N   H    sing N N 297 
LEU   N   H2   sing N N 298 
LEU   CA  C    sing N N 299 
LEU   CA  CB   sing N N 300 
LEU   CA  HA   sing N N 301 
LEU   C   O    doub N N 302 
LEU   C   OXT  sing N N 303 
LEU   CB  CG   sing N N 304 
LEU   CB  HB2  sing N N 305 
LEU   CB  HB3  sing N N 306 
LEU   CG  CD1  sing N N 307 
LEU   CG  CD2  sing N N 308 
LEU   CG  HG   sing N N 309 
LEU   CD1 HD11 sing N N 310 
LEU   CD1 HD12 sing N N 311 
LEU   CD1 HD13 sing N N 312 
LEU   CD2 HD21 sing N N 313 
LEU   CD2 HD22 sing N N 314 
LEU   CD2 HD23 sing N N 315 
LEU   OXT HXT  sing N N 316 
LYS   N   CA   sing N N 317 
LYS   N   H    sing N N 318 
LYS   N   H2   sing N N 319 
LYS   CA  C    sing N N 320 
LYS   CA  CB   sing N N 321 
LYS   CA  HA   sing N N 322 
LYS   C   O    doub N N 323 
LYS   C   OXT  sing N N 324 
LYS   CB  CG   sing N N 325 
LYS   CB  HB2  sing N N 326 
LYS   CB  HB3  sing N N 327 
LYS   CG  CD   sing N N 328 
LYS   CG  HG2  sing N N 329 
LYS   CG  HG3  sing N N 330 
LYS   CD  CE   sing N N 331 
LYS   CD  HD2  sing N N 332 
LYS   CD  HD3  sing N N 333 
LYS   CE  NZ   sing N N 334 
LYS   CE  HE2  sing N N 335 
LYS   CE  HE3  sing N N 336 
LYS   NZ  HZ1  sing N N 337 
LYS   NZ  HZ2  sing N N 338 
LYS   NZ  HZ3  sing N N 339 
LYS   OXT HXT  sing N N 340 
MET   N   CA   sing N N 341 
MET   N   H    sing N N 342 
MET   N   H2   sing N N 343 
MET   CA  C    sing N N 344 
MET   CA  CB   sing N N 345 
MET   CA  HA   sing N N 346 
MET   C   O    doub N N 347 
MET   C   OXT  sing N N 348 
MET   CB  CG   sing N N 349 
MET   CB  HB2  sing N N 350 
MET   CB  HB3  sing N N 351 
MET   CG  SD   sing N N 352 
MET   CG  HG2  sing N N 353 
MET   CG  HG3  sing N N 354 
MET   SD  CE   sing N N 355 
MET   CE  HE1  sing N N 356 
MET   CE  HE2  sing N N 357 
MET   CE  HE3  sing N N 358 
MET   OXT HXT  sing N N 359 
NAG   C1  C2   sing N N 360 
NAG   C1  O1   sing N N 361 
NAG   C1  O5   sing N N 362 
NAG   C1  H1   sing N N 363 
NAG   C2  C3   sing N N 364 
NAG   C2  N2   sing N N 365 
NAG   C2  H2   sing N N 366 
NAG   C3  C4   sing N N 367 
NAG   C3  O3   sing N N 368 
NAG   C3  H3   sing N N 369 
NAG   C4  C5   sing N N 370 
NAG   C4  O4   sing N N 371 
NAG   C4  H4   sing N N 372 
NAG   C5  C6   sing N N 373 
NAG   C5  O5   sing N N 374 
NAG   C5  H5   sing N N 375 
NAG   C6  O6   sing N N 376 
NAG   C6  H61  sing N N 377 
NAG   C6  H62  sing N N 378 
NAG   C7  C8   sing N N 379 
NAG   C7  N2   sing N N 380 
NAG   C7  O7   doub N N 381 
NAG   C8  H81  sing N N 382 
NAG   C8  H82  sing N N 383 
NAG   C8  H83  sing N N 384 
NAG   N2  HN2  sing N N 385 
NAG   O1  HO1  sing N N 386 
NAG   O3  HO3  sing N N 387 
NAG   O4  HO4  sing N N 388 
NAG   O6  HO6  sing N N 389 
PEG   C1  O1   sing N N 390 
PEG   C1  C2   sing N N 391 
PEG   C1  H11  sing N N 392 
PEG   C1  H12  sing N N 393 
PEG   O1  HO1  sing N N 394 
PEG   C2  O2   sing N N 395 
PEG   C2  H21  sing N N 396 
PEG   C2  H22  sing N N 397 
PEG   O2  C3   sing N N 398 
PEG   C3  C4   sing N N 399 
PEG   C3  H31  sing N N 400 
PEG   C3  H32  sing N N 401 
PEG   C4  O4   sing N N 402 
PEG   C4  H41  sing N N 403 
PEG   C4  H42  sing N N 404 
PEG   O4  HO4  sing N N 405 
PHE   N   CA   sing N N 406 
PHE   N   H    sing N N 407 
PHE   N   H2   sing N N 408 
PHE   CA  C    sing N N 409 
PHE   CA  CB   sing N N 410 
PHE   CA  HA   sing N N 411 
PHE   C   O    doub N N 412 
PHE   C   OXT  sing N N 413 
PHE   CB  CG   sing N N 414 
PHE   CB  HB2  sing N N 415 
PHE   CB  HB3  sing N N 416 
PHE   CG  CD1  doub Y N 417 
PHE   CG  CD2  sing Y N 418 
PHE   CD1 CE1  sing Y N 419 
PHE   CD1 HD1  sing N N 420 
PHE   CD2 CE2  doub Y N 421 
PHE   CD2 HD2  sing N N 422 
PHE   CE1 CZ   doub Y N 423 
PHE   CE1 HE1  sing N N 424 
PHE   CE2 CZ   sing Y N 425 
PHE   CE2 HE2  sing N N 426 
PHE   CZ  HZ   sing N N 427 
PHE   OXT HXT  sing N N 428 
PRO   N   CA   sing N N 429 
PRO   N   CD   sing N N 430 
PRO   N   H    sing N N 431 
PRO   CA  C    sing N N 432 
PRO   CA  CB   sing N N 433 
PRO   CA  HA   sing N N 434 
PRO   C   O    doub N N 435 
PRO   C   OXT  sing N N 436 
PRO   CB  CG   sing N N 437 
PRO   CB  HB2  sing N N 438 
PRO   CB  HB3  sing N N 439 
PRO   CG  CD   sing N N 440 
PRO   CG  HG2  sing N N 441 
PRO   CG  HG3  sing N N 442 
PRO   CD  HD2  sing N N 443 
PRO   CD  HD3  sing N N 444 
PRO   OXT HXT  sing N N 445 
SER   N   CA   sing N N 446 
SER   N   H    sing N N 447 
SER   N   H2   sing N N 448 
SER   CA  C    sing N N 449 
SER   CA  CB   sing N N 450 
SER   CA  HA   sing N N 451 
SER   C   O    doub N N 452 
SER   C   OXT  sing N N 453 
SER   CB  OG   sing N N 454 
SER   CB  HB2  sing N N 455 
SER   CB  HB3  sing N N 456 
SER   OG  HG   sing N N 457 
SER   OXT HXT  sing N N 458 
THR   N   CA   sing N N 459 
THR   N   H    sing N N 460 
THR   N   H2   sing N N 461 
THR   CA  C    sing N N 462 
THR   CA  CB   sing N N 463 
THR   CA  HA   sing N N 464 
THR   C   O    doub N N 465 
THR   C   OXT  sing N N 466 
THR   CB  OG1  sing N N 467 
THR   CB  CG2  sing N N 468 
THR   CB  HB   sing N N 469 
THR   OG1 HG1  sing N N 470 
THR   CG2 HG21 sing N N 471 
THR   CG2 HG22 sing N N 472 
THR   CG2 HG23 sing N N 473 
THR   OXT HXT  sing N N 474 
TRP   N   CA   sing N N 475 
TRP   N   H    sing N N 476 
TRP   N   H2   sing N N 477 
TRP   CA  C    sing N N 478 
TRP   CA  CB   sing N N 479 
TRP   CA  HA   sing N N 480 
TRP   C   O    doub N N 481 
TRP   C   OXT  sing N N 482 
TRP   CB  CG   sing N N 483 
TRP   CB  HB2  sing N N 484 
TRP   CB  HB3  sing N N 485 
TRP   CG  CD1  doub Y N 486 
TRP   CG  CD2  sing Y N 487 
TRP   CD1 NE1  sing Y N 488 
TRP   CD1 HD1  sing N N 489 
TRP   CD2 CE2  doub Y N 490 
TRP   CD2 CE3  sing Y N 491 
TRP   NE1 CE2  sing Y N 492 
TRP   NE1 HE1  sing N N 493 
TRP   CE2 CZ2  sing Y N 494 
TRP   CE3 CZ3  doub Y N 495 
TRP   CE3 HE3  sing N N 496 
TRP   CZ2 CH2  doub Y N 497 
TRP   CZ2 HZ2  sing N N 498 
TRP   CZ3 CH2  sing Y N 499 
TRP   CZ3 HZ3  sing N N 500 
TRP   CH2 HH2  sing N N 501 
TRP   OXT HXT  sing N N 502 
TYR   N   CA   sing N N 503 
TYR   N   H    sing N N 504 
TYR   N   H2   sing N N 505 
TYR   CA  C    sing N N 506 
TYR   CA  CB   sing N N 507 
TYR   CA  HA   sing N N 508 
TYR   C   O    doub N N 509 
TYR   C   OXT  sing N N 510 
TYR   CB  CG   sing N N 511 
TYR   CB  HB2  sing N N 512 
TYR   CB  HB3  sing N N 513 
TYR   CG  CD1  doub Y N 514 
TYR   CG  CD2  sing Y N 515 
TYR   CD1 CE1  sing Y N 516 
TYR   CD1 HD1  sing N N 517 
TYR   CD2 CE2  doub Y N 518 
TYR   CD2 HD2  sing N N 519 
TYR   CE1 CZ   doub Y N 520 
TYR   CE1 HE1  sing N N 521 
TYR   CE2 CZ   sing Y N 522 
TYR   CE2 HE2  sing N N 523 
TYR   CZ  OH   sing N N 524 
TYR   OH  HH   sing N N 525 
TYR   OXT HXT  sing N N 526 
VAL   N   CA   sing N N 527 
VAL   N   H    sing N N 528 
VAL   N   H2   sing N N 529 
VAL   CA  C    sing N N 530 
VAL   CA  CB   sing N N 531 
VAL   CA  HA   sing N N 532 
VAL   C   O    doub N N 533 
VAL   C   OXT  sing N N 534 
VAL   CB  CG1  sing N N 535 
VAL   CB  CG2  sing N N 536 
VAL   CB  HB   sing N N 537 
VAL   CG1 HG11 sing N N 538 
VAL   CG1 HG12 sing N N 539 
VAL   CG1 HG13 sing N N 540 
VAL   CG2 HG21 sing N N 541 
VAL   CG2 HG22 sing N N 542 
VAL   CG2 HG23 sing N N 543 
VAL   OXT HXT  sing N N 544 
# 
_pdbx_audit_support.funding_organization   'Biotechnology and Biological Sciences Research Council (BBSRC)' 
_pdbx_audit_support.country                'United Kingdom' 
_pdbx_audit_support.grant_number           BB/X001032/1 
_pdbx_audit_support.ordinal                1 
# 
loop_
_pdbx_entity_branch_list.entity_id 
_pdbx_entity_branch_list.comp_id 
_pdbx_entity_branch_list.num 
_pdbx_entity_branch_list.hetero 
2 NAG 1 n 
2 NAG 2 n 
2 BMA 3 n 
2 FUC 4 n 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   6F9T 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9GBM 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.017894 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.011886 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.007538 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.pdbx_scat_Z 
_atom_type.pdbx_N_electrons 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
B  5  5  2.0551  23.2185 1.3330 1.0210  1.0982 60.3498 0.7070 0.1403  -0.1933  
C  6  6  2.3103  20.8439 1.0201 10.2075 1.5888 0.5687  0.8651 51.6512 0.2156   
CL 17 17 11.4601 0.0104  7.1962 1.1662  6.2554 18.5194 1.6455 47.7784 -9.3646  
N  7  7  12.2220 0.0057  3.1346 9.8933  2.0141 28.9975 1.1672 0.5826  -11.5379 
O  8  8  3.0487  13.2771 2.2870 5.7011  1.5464 0.3239  0.8671 32.9089 0.2508   
S  16 16 6.9054  1.4679  5.2035 22.2151 1.4379 0.2536  1.5863 56.1720 1.0310   
ZN 30 30 14.0812 3.2655  7.0352 0.2333  5.1677 10.3163 2.4112 58.7097 1.1879   
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . GLU   A 1  5   ? -8.577  -28.252 -1.055  1    48.619  ? 41   GLU   A N   1 
ATOM   2    C  CA  . GLU   A 1  5   ? -9.713  -27.656 -1.818  1    51.021  ? 41   GLU   A CA  1 
ATOM   3    C  C   . GLU   A 1  5   ? -10.556 -26.81  -0.875  1    55.931  ? 41   GLU   A C   1 
ATOM   4    O  O   . GLU   A 1  5   ? -11.026 -25.734 -1.22   1    59.563  ? 41   GLU   A O   1 
ATOM   5    C  CB  . GLU   A 1  5   ? -10.67  -28.65  -2.477  1    51.377  ? 41   GLU   A CB  1 
ATOM   6    C  CG  . GLU   A 1  5   ? -11.58  -28.032 -3.536  1    54.717  ? 41   GLU   A CG  1 
ATOM   7    C  CD  . GLU   A 1  5   ? -10.995 -27.948 -4.948  1    57.409  ? 41   GLU   A CD  1 
ATOM   8    O  OE1 . GLU   A 1  5   ? -11.568 -27.198 -5.763  1    59.901  ? 41   GLU   A OE1 1 
ATOM   9    O  OE2 . GLU   A 1  5   ? -10.007 -28.659 -5.259  1    60.208  ? 41   GLU   A OE2 1 
ATOM   10   N  N   . ALA   A 1  6   ? -10.781 -27.347 0.313   1    55.963  ? 42   ALA   A N   1 
ATOM   11   C  CA  . ALA   A 1  6   ? -11.453 -26.599 1.355   1    47.703  ? 42   ALA   A CA  1 
ATOM   12   C  C   . ALA   A 1  6   ? -10.518 -25.478 1.862   1    44.214  ? 42   ALA   A C   1 
ATOM   13   O  O   . ALA   A 1  6   ? -10.931 -24.386 2.265   1    34.808  ? 42   ALA   A O   1 
ATOM   14   C  CB  . ALA   A 1  6   ? -11.861 -27.612 2.424   1    44.657  ? 42   ALA   A CB  1 
ATOM   15   N  N   . GLU   A 1  7   ? -9.204  -25.714 1.814   1    39.931  ? 43   GLU   A N   1 
ATOM   16   C  CA  . GLU   A 1  7   ? -8.32   -24.627 2.178   1    41.148  ? 43   GLU   A CA  1 
ATOM   17   C  C   . GLU   A 1  7   ? -8.443  -23.521 1.121   1    41.828  ? 43   GLU   A C   1 
ATOM   18   O  O   . GLU   A 1  7   ? -8.429  -22.319 1.436   1    34.923  ? 43   GLU   A O   1 
ATOM   19   C  CB  . GLU   A 1  7   ? -6.868  -25.029 2.458   1    45.67   ? 43   GLU   A CB  1 
ATOM   20   C  CG  . GLU   A 1  7   ? -6.628  -25.232 3.957   1    59.539  ? 43   GLU   A CG  1 
ATOM   21   C  CD  . GLU   A 1  7   ? -5.19   -25.285 4.47    1    78.396  ? 43   GLU   A CD  1 
ATOM   22   O  OE1 . GLU   A 1  7   ? -4.767  -26.33  5.018   1    67.901  ? 43   GLU   A OE1 1 
ATOM   23   O  OE2 . GLU   A 1  7   ? -4.48   -24.258 4.357   1    95.545  ? 43   GLU   A OE2 1 
ATOM   24   N  N   . ALA   A 1  8   ? -8.607  -23.945 -0.132  1    41.027  ? 44   ALA   A N   1 
ATOM   25   C  CA  . ALA   A 1  8   ? -8.651  -22.957 -1.209  1    42.528  ? 44   ALA   A CA  1 
ATOM   26   C  C   . ALA   A 1  8   ? -9.941  -22.14  -1.126  1    33.325  ? 44   ALA   A C   1 
ATOM   27   O  O   . ALA   A 1  8   ? -9.942  -20.939 -1.315  1    27.602  ? 44   ALA   A O   1 
ATOM   28   C  CB  . ALA   A 1  8   ? -8.422  -23.586 -2.569  1    35.018  ? 44   ALA   A CB  1 
ATOM   29   N  N   . SER   A 1  9   ? -11.056 -22.782 -0.806  1    28.845  ? 45   SER   A N   1 
ATOM   30   C  CA  . SER   A 1  9   ? -12.31  -22.084 -0.635  1    30.698  ? 45   SER   A CA  1 
ATOM   31   C  C   . SER   A 1  9   ? -12.238 -21.05  0.503   1    31.102  ? 45   SER   A C   1 
ATOM   32   O  O   . SER   A 1  9   ? -12.774 -19.955 0.37    1    35.496  ? 45   SER   A O   1 
ATOM   33   C  CB  . SER   A 1  9   ? -13.406 -23.106 -0.336  1    31.272  ? 45   SER   A CB  1 
ATOM   34   O  OG  . SER   A 1  9   ? -14.635 -22.567 -0.795  1    41.767  ? 45   SER   A OG  1 
ATOM   35   N  N   . LYS   A 1  10  ? -11.683 -21.42  1.648   1    29.099  ? 46   LYS   A N   1 
ATOM   36   C  CA  . LYS   A 1  10  ? -11.636 -20.53  2.806   1    31.873  ? 46   LYS   A CA  1 
ATOM   37   C  C   . LYS   A 1  10  ? -10.76  -19.304 2.473   1    27.411  ? 46   LYS   A C   1 
ATOM   38   O  O   . LYS   A 1  10  ? -11.049 -18.158 2.84    1    24.579  ? 46   LYS   A O   1 
ATOM   39   C  CB  . LYS   A 1  10  ? -11.147 -21.403 3.977   1    38.362  ? 46   LYS   A CB  1 
ATOM   40   C  CG  . LYS   A 1  10  ? -11.165 -20.719 5.355   1    38.117  ? 46   LYS   A CG  1 
ATOM   41   C  CD  . LYS   A 1  10  ? -9.87   -20.814 6.17    1    53.803  ? 46   LYS   A CD  1 
ATOM   42   C  CE  . LYS   A 1  10  ? -9.274  -22.194 6.363   1    64.979  ? 46   LYS   A CE  1 
ATOM   43   N  NZ  . LYS   A 1  10  ? -7.878  -22.231 6.839   1    70.237  ? 46   LYS   A NZ  1 
ATOM   44   N  N   . PHE   A 1  11  ? -9.658  -19.551 1.753   1    28.128  ? 47   PHE   A N   1 
ATOM   45   C  CA  . PHE   A 1  11  ? -8.753  -18.492 1.382   1    28.972  ? 47   PHE   A CA  1 
ATOM   46   C  C   . PHE   A 1  11  ? -9.486  -17.471 0.508   1    23.916  ? 47   PHE   A C   1 
ATOM   47   O  O   . PHE   A 1  11  ? -9.364  -16.272 0.723   1    25.952  ? 47   PHE   A O   1 
ATOM   48   C  CB  . PHE   A 1  11  ? -7.508  -19.043 0.679   1    27.25   ? 47   PHE   A CB  1 
ATOM   49   C  CG  . PHE   A 1  11  ? -6.773  -17.893 0.016   1    30.143  ? 47   PHE   A CG  1 
ATOM   50   C  CD1 . PHE   A 1  11  ? -5.848  -17.115 0.726   1    26.552  ? 47   PHE   A CD1 1 
ATOM   51   C  CD2 . PHE   A 1  11  ? -7.022  -17.585 -1.316  1    24.829  ? 47   PHE   A CD2 1 
ATOM   52   C  CE1 . PHE   A 1  11  ? -5.15   -16.1   0.094   1    30.552  ? 47   PHE   A CE1 1 
ATOM   53   C  CE2 . PHE   A 1  11  ? -6.318  -16.553 -1.939  1    28.463  ? 47   PHE   A CE2 1 
ATOM   54   C  CZ  . PHE   A 1  11  ? -5.403  -15.792 -1.221  1    25.961  ? 47   PHE   A CZ  1 
ATOM   55   N  N   . VAL   A 1  12  ? -10.229 -17.914 -0.503  1    25.077  ? 48   VAL   A N   1 
ATOM   56   C  CA  . VAL   A 1  12  ? -10.885 -16.902 -1.338  1    26.614  ? 48   VAL   A CA  1 
ATOM   57   C  C   . VAL   A 1  12  ? -11.919 -16.153 -0.514  1    31.581  ? 48   VAL   A C   1 
ATOM   58   O  O   . VAL   A 1  12  ? -12.233 -14.965 -0.762  1    24.553  ? 48   VAL   A O   1 
ATOM   59   C  CB  . VAL   A 1  12  ? -11.509 -17.434 -2.66   1    27.038  ? 48   VAL   A CB  1 
ATOM   60   C  CG1 . VAL   A 1  12  ? -10.443 -18.004 -3.59   1    24.049  ? 48   VAL   A CG1 1 
ATOM   61   C  CG2 . VAL   A 1  12  ? -12.589 -18.478 -2.515  1    28.726  ? 48   VAL   A CG2 1 
ATOM   62   N  N   . GLU   A 1  13  ? -12.523 -16.879 0.446   1    26.841  ? 49   GLU   A N   1 
ATOM   63   C  CA  . GLU   A 1  13  ? -13.56  -16.172 1.205   1    28.598  ? 49   GLU   A CA  1 
ATOM   64   C  C   . GLU   A 1  13  ? -12.933 -15.066 2.057   1    22.436  ? 49   GLU   A C   1 
ATOM   65   O  O   . GLU   A 1  13  ? -13.479 -13.959 2.123   1    23.998  ? 49   GLU   A O   1 
ATOM   66   C  CB  . GLU   A 1  13  ? -14.368 -17.129 2.086   1    35.311  ? 49   GLU   A CB  1 
ATOM   67   C  CG  . GLU   A 1  13  ? -15.329 -18.006 1.296   1    34.522  ? 49   GLU   A CG  1 
ATOM   68   C  CD  . GLU   A 1  13  ? -15.797 -19.228 2.077   1    46.823  ? 49   GLU   A CD  1 
ATOM   69   O  OE1 . GLU   A 1  13  ? -15.204 -19.556 3.152   1    47.514  ? 49   GLU   A OE1 1 
ATOM   70   O  OE2 . GLU   A 1  13  ? -16.787 -19.845 1.603   1    49.937  ? 49   GLU   A OE2 1 
ATOM   71   N  N   . GLU   A 1  14  ? -11.797 -15.35  2.72    1    20.951  ? 50   GLU   A N   1 
ATOM   72   C  CA  . GLU   A 1  14  ? -11.024 -14.374 3.485   1    24.766  ? 50   GLU   A CA  1 
ATOM   73   C  C   . GLU   A 1  14  ? -10.498 -13.241 2.604   1    23.968  ? 50   GLU   A C   1 
ATOM   74   O  O   . GLU   A 1  14  ? -10.633 -12.074 2.967   1    25.868  ? 50   GLU   A O   1 
ATOM   75   C  CB  . GLU   A 1  14  ? -9.862  -14.92  4.326   1    23.425  ? 50   GLU   A CB  1 
ATOM   76   C  CG  . GLU   A 1  14  ? -10.424 -15.919 5.339   1    31.142  ? 50   GLU   A CG  1 
ATOM   77   C  CD  . GLU   A 1  14  ? -9.324  -16.68  6.076   1    36.459  ? 50   GLU   A CD  1 
ATOM   78   O  OE1 . GLU   A 1  14  ? -8.126  -16.358 5.9     1    32.815  ? 50   GLU   A OE1 1 
ATOM   79   O  OE2 . GLU   A 1  14  ? -9.726  -17.587 6.837   1    38.265  ? 50   GLU   A OE2 1 
ATOM   80   N  N   . TYR   A 1  15  ? -9.92   -13.619 1.436   1    24.325  ? 51   TYR   A N   1 
ATOM   81   C  CA  . TYR   A 1  15  ? -9.537  -12.584 0.495   1    22.432  ? 51   TYR   A CA  1 
ATOM   82   C  C   . TYR   A 1  15  ? -10.739 -11.684 0.198   1    20.689  ? 51   TYR   A C   1 
ATOM   83   O  O   . TYR   A 1  15  ? -10.607 -10.458 0.164   1    24.423  ? 51   TYR   A O   1 
ATOM   84   C  CB  . TYR   A 1  15  ? -9.027  -13.272 -0.758  1    24.547  ? 51   TYR   A CB  1 
ATOM   85   C  CG  . TYR   A 1  15  ? -8.721  -12.2   -1.792  1    22.486  ? 51   TYR   A CG  1 
ATOM   86   C  CD1 . TYR   A 1  15  ? -7.554  -11.458 -1.706  1    23.99   ? 51   TYR   A CD1 1 
ATOM   87   C  CD2 . TYR   A 1  15  ? -9.588  -11.965 -2.847  1    24.551  ? 51   TYR   A CD2 1 
ATOM   88   C  CE1 . TYR   A 1  15  ? -7.245  -10.482 -2.656  1    23.366  ? 51   TYR   A CE1 1 
ATOM   89   C  CE2 . TYR   A 1  15  ? -9.283  -11.005 -3.814  1    23.013  ? 51   TYR   A CE2 1 
ATOM   90   C  CZ  . TYR   A 1  15  ? -8.118  -10.268 -3.711  1    25.919  ? 51   TYR   A CZ  1 
ATOM   91   O  OH  . TYR   A 1  15  ? -7.788  -9.327  -4.646  1    25.463  ? 51   TYR   A OH  1 
ATOM   92   N  N   . ASP   A 1  16  ? -11.909 -12.261 -0.061  1    23.253  ? 52   ASP   A N   1 
ATOM   93   C  CA  . ASP   A 1  16  ? -13.028 -11.406 -0.443  1    26.758  ? 52   ASP   A CA  1 
ATOM   94   C  C   . ASP   A 1  16  ? -13.418 -10.41  0.671   1    30.237  ? 52   ASP   A C   1 
ATOM   95   O  O   . ASP   A 1  16  ? -13.672 -9.221  0.416   1    22.683  ? 52   ASP   A O   1 
ATOM   96   C  CB  . ASP   A 1  16  ? -14.237 -12.215 -0.919  1    25.486  ? 52   ASP   A CB  1 
ATOM   97   C  CG  . ASP   A 1  16  ? -15.295 -11.328 -1.593  1    37.089  ? 52   ASP   A CG  1 
ATOM   98   O  OD1 . ASP   A 1  16  ? -14.97  -10.637 -2.586  1    35.826  ? 52   ASP   A OD1 1 
ATOM   99   O  OD2 . ASP   A 1  16  ? -16.426 -11.267 -1.115  1    33.885  ? 52   ASP   A OD2 1 
ATOM   100  N  N   . ARG   A 1  17  ? -13.522 -10.87  1.944   1    27.291  ? 53   ARG   A N   1 
ATOM   101  C  CA  . ARG   A 1  17  ? -14.08  -9.958  2.945   1    24.088  ? 53   ARG   A CA  1 
ATOM   102  C  C   . ARG   A 1  17  ? -13.096 -8.836  3.213   1    21.032  ? 53   ARG   A C   1 
ATOM   103  O  O   . ARG   A 1  17  ? -13.479 -7.667  3.372   1    26.093  ? 53   ARG   A O   1 
ATOM   104  C  CB  . ARG   A 1  17  ? -14.136 -10.745 4.258   1    29.199  ? 53   ARG   A CB  1 
ATOM   105  C  CG  . ARG   A 1  17  ? -15.123 -11.887 4.15    1    30.713  ? 53   ARG   A CG  1 
ATOM   106  C  CD  . ARG   A 1  17  ? -14.847 -12.732 5.343   1    32.381  ? 53   ARG   A CD  1 
ATOM   107  N  NE  . ARG   A 1  17  ? -15.831 -13.802 5.286   1    31.35   ? 53   ARG   A NE  1 
ATOM   108  C  CZ  . ARG   A 1  17  ? -15.455 -15.045 5.444   1    31.312  ? 53   ARG   A CZ  1 
ATOM   109  N  NH1 . ARG   A 1  17  ? -14.217 -15.323 5.855   1    31.499  ? 53   ARG   A NH1 1 
ATOM   110  N  NH2 . ARG   A 1  17  ? -16.349 -15.988 5.226   1    37.414  ? 53   ARG   A NH2 1 
ATOM   111  N  N   . THR   A 1  18  ? -11.815 -9.193  3.239   1    20.158  ? 54   THR   A N   1 
ATOM   112  C  CA  . THR   A 1  18  ? -10.764 -8.226  3.575   1    23.381  ? 54   THR   A CA  1 
ATOM   113  C  C   . THR   A 1  18  ? -10.542 -7.255  2.413   1    25.199  ? 54   THR   A C   1 
ATOM   114  O  O   . THR   A 1  18  ? -10.446 -6.038  2.651   1    26.023  ? 54   THR   A O   1 
ATOM   115  C  CB  . THR   A 1  18  ? -9.47   -8.899  4.021   1    24.631  ? 54   THR   A CB  1 
ATOM   116  O  OG1 . THR   A 1  18  ? -8.999  -9.771  2.992   1    25.223  ? 54   THR   A OG1 1 
ATOM   117  C  CG2 . THR   A 1  18  ? -9.616  -9.784  5.246   1    23.38   ? 54   THR   A CG2 1 
ATOM   118  N  N   . SER   A 1  19  ? -10.671 -7.75   1.146   1    23.682  ? 55   SER   A N   1 
ATOM   119  C  CA  . SER   A 1  19  ? -10.573 -6.841  -0.009  1    23.323  ? 55   SER   A CA  1 
ATOM   120  C  C   . SER   A 1  19  ? -11.651 -5.769  -0.037  1    23.053  ? 55   SER   A C   1 
ATOM   121  O  O   . SER   A 1  19  ? -11.329 -4.649  -0.373  1    29.452  ? 55   SER   A O   1 
ATOM   122  C  CB  . SER   A 1  19  ? -10.558 -7.607  -1.359  1    20.389  ? 55   SER   A CB  1 
ATOM   123  O  OG  . SER   A 1  19  ? -9.411  -8.407  -1.374  1    24.762  ? 55   SER   A OG  1 
ATOM   124  N  N   . GLN   A 1  20  ? -12.93  -6.11   0.269   1    27.303  ? 56   GLN   A N   1 
ATOM   125  C  CA  . GLN   A 1  20  ? -14.003 -5.115  0.312   1    24.945  ? 56   GLN   A CA  1 
ATOM   126  C  C   . GLN   A 1  20  ? -13.603 -3.938  1.179   1    23.607  ? 56   GLN   A C   1 
ATOM   127  O  O   . GLN   A 1  20  ? -13.765 -2.774  0.777   1    23.822  ? 56   GLN   A O   1 
ATOM   128  C  CB  . GLN   A 1  20  ? -15.329 -5.686  0.812   1    26.253  ? 56   GLN   A CB  1 
ATOM   129  C  CG  . GLN   A 1  20  ? -15.85  -6.692  -0.209  1    35.275  ? 56   GLN   A CG  1 
ATOM   130  C  CD  . GLN   A 1  20  ? -17.137 -7.363  0.175   1    43.118  ? 56   GLN   A CD  1 
ATOM   131  O  OE1 . GLN   A 1  20  ? -18.107 -6.691  0.525   1    45.602  ? 56   GLN   A OE1 1 
ATOM   132  N  NE2 . GLN   A 1  20  ? -17.159 -8.687  0.093   1    53.714  ? 56   GLN   A NE2 1 
ATOM   133  N  N   . VAL   A 1  21  ? -13.103 -4.275  2.391   1    25.012  ? 57   VAL   A N   1 
ATOM   134  C  CA  . VAL   A 1  21  ? -12.822 -3.232  3.368   1    23.256  ? 57   VAL   A CA  1 
ATOM   135  C  C   . VAL   A 1  21  ? -11.701 -2.365  2.82    1    22.764  ? 57   VAL   A C   1 
ATOM   136  O  O   . VAL   A 1  21  ? -11.815 -1.134  2.816   1    22.287  ? 57   VAL   A O   1 
ATOM   137  C  CB  . VAL   A 1  21  ? -12.429 -3.851  4.733   1    30.924  ? 57   VAL   A CB  1 
ATOM   138  C  CG1 . VAL   A 1  21  ? -12.143 -2.777  5.772   1    31.258  ? 57   VAL   A CG1 1 
ATOM   139  C  CG2 . VAL   A 1  21  ? -13.491 -4.794  5.297   1    30.304  ? 57   VAL   A CG2 1 
ATOM   140  N  N   . VAL   A 1  22  ? -10.574 -3.027  2.441   1    23.865  ? 58   VAL   A N   1 
ATOM   141  C  CA  . VAL   A 1  22  ? -9.406  -2.269  2.061   1    25.865  ? 58   VAL   A CA  1 
ATOM   142  C  C   . VAL   A 1  22  ? -9.685  -1.456  0.791   1    22.577  ? 58   VAL   A C   1 
ATOM   143  O  O   . VAL   A 1  22  ? -9.225  -0.303  0.734   1    23.018  ? 58   VAL   A O   1 
ATOM   144  C  CB  . VAL   A 1  22  ? -8.171  -3.178  1.915   1    31.176  ? 58   VAL   A CB  1 
ATOM   145  C  CG1 . VAL   A 1  22  ? -6.961  -2.324  1.593   1    32.826  ? 58   VAL   A CG1 1 
ATOM   146  C  CG2 . VAL   A 1  22  ? -7.95   -3.96   3.224   1    36.983  ? 58   VAL   A CG2 1 
ATOM   147  N  N   . TRP   A 1  23  ? -10.313 -2.063  -0.247  1    22.917  ? 59   TRP   A N   1 
ATOM   148  C  CA  . TRP   A 1  23  ? -10.56  -1.307  -1.497  1    24.122  ? 59   TRP   A CA  1 
ATOM   149  C  C   . TRP   A 1  23  ? -11.57  -0.179  -1.25   1    23.215  ? 59   TRP   A C   1 
ATOM   150  O  O   . TRP   A 1  23  ? -11.411 0.917   -1.763  1    24.122  ? 59   TRP   A O   1 
ATOM   151  C  CB  . TRP   A 1  23  ? -11.027 -2.189  -2.675  1    24.183  ? 59   TRP   A CB  1 
ATOM   152  C  CG  . TRP   A 1  23  ? -10.111 -3.325  -3.101  1    35.204  ? 59   TRP   A CG  1 
ATOM   153  C  CD1 . TRP   A 1  23  ? -8.978  -3.744  -2.484  1    35.348  ? 59   TRP   A CD1 1 
ATOM   154  C  CD2 . TRP   A 1  23  ? -10.278 -4.249  -4.211  1    43.059  ? 59   TRP   A CD2 1 
ATOM   155  N  NE1 . TRP   A 1  23  ? -8.417  -4.814  -3.126  1    34.407  ? 59   TRP   A NE1 1 
ATOM   156  C  CE2 . TRP   A 1  23  ? -9.193  -5.172  -4.179  1    46.663  ? 59   TRP   A CE2 1 
ATOM   157  C  CE3 . TRP   A 1  23  ? -11.22  -4.409  -5.242  1    54.015  ? 59   TRP   A CE3 1 
ATOM   158  C  CZ2 . TRP   A 1  23  ? -9.017  -6.208  -5.117  1    51.77   ? 59   TRP   A CZ2 1 
ATOM   159  C  CZ3 . TRP   A 1  23  ? -11.045 -5.431  -6.171  1    60.454  ? 59   TRP   A CZ3 1 
ATOM   160  C  CH2 . TRP   A 1  23  ? -9.967  -6.328  -6.112  1    50.375  ? 59   TRP   A CH2 1 
ATOM   161  N  N   . ASN   A 1  24  ? -12.537 -0.388  -0.355  1    22.069  ? 60   ASN   A N   1 
ATOM   162  C  CA  . ASN   A 1  24  ? -13.432 0.701   0.019   1    24.831  ? 60   ASN   A CA  1 
ATOM   163  C  C   . ASN   A 1  24  ? -12.663 1.912   0.572   1    25.299  ? 60   ASN   A C   1 
ATOM   164  O  O   . ASN   A 1  24  ? -12.942 3.058   0.199   1    26.121  ? 60   ASN   A O   1 
ATOM   165  C  CB  . ASN   A 1  24  ? -14.593 0.148   0.843   1    22.953  ? 60   ASN   A CB  1 
ATOM   166  C  CG  . ASN   A 1  24  ? -15.393 1.297   1.379   1    28.152  ? 60   ASN   A CG  1 
ATOM   167  O  OD1 . ASN   A 1  24  ? -14.969 1.905   2.371   1    27.474  ? 60   ASN   A OD1 1 
ATOM   168  N  ND2 . ASN   A 1  24  ? -16.443 1.684   0.656   1    24.017  ? 60   ASN   A ND2 1 
ATOM   169  N  N   . GLU   A 1  25  ? -11.708 1.675   1.491   1    26.182  ? 61   GLU   A N   1 
ATOM   170  C  CA  . GLU   A 1  25  ? -10.925 2.755   2.074   1    27.312  ? 61   GLU   A CA  1 
ATOM   171  C  C   . GLU   A 1  25  ? -10.095 3.415   0.977   1    25.318  ? 61   GLU   A C   1 
ATOM   172  O  O   . GLU   A 1  25  ? -9.955  4.637   0.911   1    25.562  ? 61   GLU   A O   1 
ATOM   173  C  CB  . GLU   A 1  25  ? -9.956  2.312   3.188   1    23.667  ? 61   GLU   A CB  1 
ATOM   174  C  CG  . GLU   A 1  25  ? -10.756 1.638   4.286   1    34.921  ? 61   GLU   A CG  1 
ATOM   175  C  CD  . GLU   A 1  25  ? -9.916  1.627   5.548   1    47.703  ? 61   GLU   A CD  1 
ATOM   176  O  OE1 . GLU   A 1  25  ? -8.811  2.263   5.656   1    48.718  ? 61   GLU   A OE1 1 
ATOM   177  O  OE2 . GLU   A 1  25  ? -10.446 0.948   6.442   1    50.601  ? 61   GLU   A OE2 1 
ATOM   178  N  N   . TYR   A 1  26  ? -9.511  2.586   0.117   1    25.246  ? 62   TYR   A N   1 
ATOM   179  C  CA  . TYR   A 1  26  ? -8.683  3.194   -0.919  1    23.018  ? 62   TYR   A CA  1 
ATOM   180  C  C   . TYR   A 1  26  ? -9.499  4.084   -1.864  1    22.35   ? 62   TYR   A C   1 
ATOM   181  O  O   . TYR   A 1  26  ? -9.052  5.199   -2.217  1    25.016  ? 62   TYR   A O   1 
ATOM   182  C  CB  . TYR   A 1  26  ? -7.845  2.137   -1.613  1    23.879  ? 62   TYR   A CB  1 
ATOM   183  C  CG  . TYR   A 1  26  ? -7.111  2.725   -2.8    1    25.511  ? 62   TYR   A CG  1 
ATOM   184  C  CD1 . TYR   A 1  26  ? -7.736  2.768   -4.048  1    32.188  ? 62   TYR   A CD1 1 
ATOM   185  C  CD2 . TYR   A 1  26  ? -5.797  3.224   -2.693  1    28.721  ? 62   TYR   A CD2 1 
ATOM   186  C  CE1 . TYR   A 1  26  ? -7.073  3.314   -5.144  1    33.972  ? 62   TYR   A CE1 1 
ATOM   187  C  CE2 . TYR   A 1  26  ? -5.12   3.757   -3.798  1    32.094  ? 62   TYR   A CE2 1 
ATOM   188  C  CZ  . TYR   A 1  26  ? -5.774  3.804   -5.022  1    37.186  ? 62   TYR   A CZ  1 
ATOM   189  O  OH  . TYR   A 1  26  ? -5.184  4.299   -6.158  1    40.368  ? 62   TYR   A OH  1 
ATOM   190  N  N   . ALA   A 1  27  ? -10.658 3.559   -2.279  1    21.798  ? 63   ALA   A N   1 
ATOM   191  C  CA  . ALA   A 1  27  ? -11.571 4.222   -3.198  1    22.473  ? 63   ALA   A CA  1 
ATOM   192  C  C   . ALA   A 1  27  ? -11.97  5.586   -2.641  1    24.884  ? 63   ALA   A C   1 
ATOM   193  O  O   . ALA   A 1  27  ? -11.83  6.628   -3.326  1    24.931  ? 63   ALA   A O   1 
ATOM   194  C  CB  . ALA   A 1  27  ? -12.728 3.266   -3.512  1    21.177  ? 63   ALA   A CB  1 
ATOM   195  N  N   . GLY   A 1  28  ? -12.229 5.617   -1.32   1    25.129  ? 64   GLY   A N   1 
ATOM   196  C  CA  . GLY   A 1  28  ? -12.531 6.834   -0.585  1    22.205  ? 64   GLY   A CA  1 
ATOM   197  C  C   . GLY   A 1  28  ? -11.435 7.877   -0.678  1    25.493  ? 64   GLY   A C   1 
ATOM   198  O  O   . GLY   A 1  28  ? -11.676 9.073   -0.988  1    22.662  ? 64   GLY   A O   1 
ATOM   199  N  N   . ALA   A 1  29  ? -10.205 7.421   -0.41   1    25.49   ? 65   ALA   A N   1 
ATOM   200  C  CA  . ALA   A 1  29  ? -9.109  8.376   -0.43   1    27.446  ? 65   ALA   A CA  1 
ATOM   201  C  C   . ALA   A 1  29  ? -8.819  8.87    -1.863  1    29.791  ? 65   ALA   A C   1 
ATOM   202  O  O   . ALA   A 1  29  ? -8.406  10.039  -2.102  1    21.806  ? 65   ALA   A O   1 
ATOM   203  C  CB  . ALA   A 1  29  ? -7.86   7.751   0.182   1    24.221  ? 65   ALA   A CB  1 
ATOM   204  N  N   . ASN   A 1  30  ? -8.949  7.933   -2.817  1    22.671  ? 66   ASN   A N   1 
ATOM   205  C  CA  . ASN   A 1  30  ? -8.674  8.282   -4.213  1    20.989  ? 66   ASN   A CA  1 
ATOM   206  C  C   . ASN   A 1  30  ? -9.739  9.268   -4.676  1    19.676  ? 66   ASN   A C   1 
ATOM   207  O  O   . ASN   A 1  30  ? -9.415  10.285  -5.331  1    24.443  ? 66   ASN   A O   1 
ATOM   208  C  CB  . ASN   A 1  30  ? -8.778  7.013   -5.062  1    24.634  ? 66   ASN   A CB  1 
ATOM   209  C  CG  . ASN   A 1  30  ? -8.25   7.186   -6.472  1    24.165  ? 66   ASN   A CG  1 
ATOM   210  O  OD1 . ASN   A 1  30  ? -7.421  8.076   -6.697  1    25.119  ? 66   ASN   A OD1 1 
ATOM   211  N  ND2 . ASN   A 1  30  ? -8.559  6.227   -7.342  1    22.927  ? 66   ASN   A ND2 1 
ATOM   212  N  N   . TRP   A 1  31  ? -11.003 8.984   -4.278  1    20.887  ? 67   TRP   A N   1 
ATOM   213  C  CA  . TRP   A 1  31  ? -12.08  9.923   -4.569  1    22.117  ? 67   TRP   A CA  1 
ATOM   214  C  C   . TRP   A 1  31  ? -11.762 11.352  -4.082  1    26.104  ? 67   TRP   A C   1 
ATOM   215  O  O   . TRP   A 1  31  ? -11.881 12.382  -4.812  1    24.677  ? 67   TRP   A O   1 
ATOM   216  C  CB  . TRP   A 1  31  ? -13.415 9.38    -4.041  1    20.539  ? 67   TRP   A CB  1 
ATOM   217  C  CG  . TRP   A 1  31  ? -14.511 10.407  -4.152  1    25.463  ? 67   TRP   A CG  1 
ATOM   218  C  CD1 . TRP   A 1  31  ? -14.819 11.39   -3.261  1    26.997  ? 67   TRP   A CD1 1 
ATOM   219  C  CD2 . TRP   A 1  31  ? -15.454 10.551  -5.248  1    31.182  ? 67   TRP   A CD2 1 
ATOM   220  N  NE1 . TRP   A 1  31  ? -15.906 12.112  -3.697  1    28.171  ? 67   TRP   A NE1 1 
ATOM   221  C  CE2 . TRP   A 1  31  ? -16.314 11.634  -4.921  1    31.184  ? 67   TRP   A CE2 1 
ATOM   222  C  CE3 . TRP   A 1  31  ? -15.643 9.892   -6.486  1    26.232  ? 67   TRP   A CE3 1 
ATOM   223  C  CZ2 . TRP   A 1  31  ? -17.338 12.055  -5.783  1    28.123  ? 67   TRP   A CZ2 1 
ATOM   224  C  CZ3 . TRP   A 1  31  ? -16.633 10.341  -7.348  1    24.244  ? 67   TRP   A CZ3 1 
ATOM   225  C  CH2 . TRP   A 1  31  ? -17.464 11.42   -7.011  1    26.4    ? 67   TRP   A CH2 1 
ATOM   226  N  N   . ASN   A 1  32  ? -11.404 11.447  -2.798  1    24.279  ? 68   ASN   A N   1 
ATOM   227  C  CA  . ASN   A 1  32  ? -11.231 12.756  -2.132  1    23.959  ? 68   ASN   A CA  1 
ATOM   228  C  C   . ASN   A 1  32  ? -10.107 13.536  -2.796  1    23.566  ? 68   ASN   A C   1 
ATOM   229  O  O   . ASN   A 1  32  ? -10.153 14.769  -2.943  1    32.428  ? 68   ASN   A O   1 
ATOM   230  C  CB  . ASN   A 1  32  ? -10.903 12.584  -0.651  1    25.883  ? 68   ASN   A CB  1 
ATOM   231  C  CG  . ASN   A 1  32  ? -12.078 12      0.092   1    33.038  ? 68   ASN   A CG  1 
ATOM   232  O  OD1 . ASN   A 1  32  ? -13.226 12.078  -0.363  1    36.912  ? 68   ASN   A OD1 1 
ATOM   233  N  ND2 . ASN   A 1  32  ? -11.817 11.406  1.252   1    33.565  ? 68   ASN   A ND2 1 
ATOM   234  N  N   . TYR   A 1  33  ? -9.085  12.807  -3.222  1    23.771  ? 69   TYR   A N   1 
ATOM   235  C  CA  . TYR   A 1  33  ? -8.011  13.469  -3.98   1    23.988  ? 69   TYR   A CA  1 
ATOM   236  C  C   . TYR   A 1  33  ? -8.521  13.943  -5.344  1    25.703  ? 69   TYR   A C   1 
ATOM   237  O  O   . TYR   A 1  33  ? -8.235  15.075  -5.731  1    24.406  ? 69   TYR   A O   1 
ATOM   238  C  CB  . TYR   A 1  33  ? -6.728  12.638  -4.072  1    25.876  ? 69   TYR   A CB  1 
ATOM   239  C  CG  . TYR   A 1  33  ? -5.774  13.082  -5.188  1    32.38   ? 69   TYR   A CG  1 
ATOM   240  C  CD1 . TYR   A 1  33  ? -4.837  14.128  -5.067  1    38.273  ? 69   TYR   A CD1 1 
ATOM   241  C  CD2 . TYR   A 1  33  ? -5.885  12.438  -6.406  1    39.12   ? 69   TYR   A CD2 1 
ATOM   242  C  CE1 . TYR   A 1  33  ? -4.025  14.487  -6.15   1    39.456  ? 69   TYR   A CE1 1 
ATOM   243  C  CE2 . TYR   A 1  33  ? -5.104  12.793  -7.488  1    52.171  ? 69   TYR   A CE2 1 
ATOM   244  C  CZ  . TYR   A 1  33  ? -4.185  13.813  -7.362  1    45.21   ? 69   TYR   A CZ  1 
ATOM   245  O  OH  . TYR   A 1  33  ? -3.535  13.934  -8.566  1    53.655  ? 69   TYR   A OH  1 
ATOM   246  N  N   . ASN   A 1  34  ? -9.217  13.05   -6.105  1    26.983  ? 70   ASN   A N   1 
ATOM   247  C  CA  . ASN   A 1  34  ? -9.669  13.408  -7.447  1    25.577  ? 70   ASN   A CA  1 
ATOM   248  C  C   . ASN   A 1  34  ? -10.636 14.581  -7.436  1    21.924  ? 70   ASN   A C   1 
ATOM   249  O  O   . ASN   A 1  34  ? -10.732 15.279  -8.437  1    24.637  ? 70   ASN   A O   1 
ATOM   250  C  CB  . ASN   A 1  34  ? -10.391 12.265  -8.158  1    24.31   ? 70   ASN   A CB  1 
ATOM   251  C  CG  . ASN   A 1  34  ? -9.41   11.38   -8.908  1    26.174  ? 70   ASN   A CG  1 
ATOM   252  O  OD1 . ASN   A 1  34  ? -9.396  11.391  -10.147 1    23.589  ? 70   ASN   A OD1 1 
ATOM   253  N  ND2 . ASN   A 1  34  ? -8.582  10.608  -8.195  1    22.032  ? 70   ASN   A ND2 1 
ATOM   254  N  N   . THR   A 1  35  ? -11.405 14.732  -6.367  1    19.629  ? 71   THR   A N   1 
ATOM   255  C  CA  . THR   A 1  35  ? -12.429 15.77   -6.287  1    23.762  ? 71   THR   A CA  1 
ATOM   256  C  C   . THR   A 1  35  ? -11.899 16.966  -5.481  1    32.273  ? 71   THR   A C   1 
ATOM   257  O  O   . THR   A 1  35  ? -12.652 17.919  -5.247  1    30.113  ? 71   THR   A O   1 
ATOM   258  C  CB  . THR   A 1  35  ? -13.704 15.178  -5.71   1    26.461  ? 71   THR   A CB  1 
ATOM   259  O  OG1 . THR   A 1  35  ? -13.402 14.702  -4.406  1    29.078  ? 71   THR   A OG1 1 
ATOM   260  C  CG2 . THR   A 1  35  ? -14.306 14.08   -6.596  1    22.173  ? 71   THR   A CG2 1 
ATOM   261  N  N   . ASN   A 1  36  ? -10.582 16.968  -5.161  1    27.136  ? 72   ASN   A N   1 
ATOM   262  C  CA  . ASN   A 1  36  ? -10.044 18.006  -4.279  1    28.232  ? 72   ASN   A CA  1 
ATOM   263  C  C   . ASN   A 1  36  ? -8.53   17.822  -4.154  1    28.96   ? 72   ASN   A C   1 
ATOM   264  O  O   . ASN   A 1  36  ? -8.039  17.266  -3.186  1    35.849  ? 72   ASN   A O   1 
ATOM   265  C  CB  . ASN   A 1  36  ? -10.718 17.918  -2.912  1    28.145  ? 72   ASN   A CB  1 
ATOM   266  C  CG  . ASN   A 1  36  ? -10.368 19.063  -1.982  1    39.22   ? 72   ASN   A CG  1 
ATOM   267  O  OD1 . ASN   A 1  36  ? -9.838  20.103  -2.417  1    37.202  ? 72   ASN   A OD1 1 
ATOM   268  N  ND2 . ASN   A 1  36  ? -10.685 18.862  -0.703  1    52.497  ? 72   ASN   A ND2 1 
ATOM   269  N  N   . ILE   A 1  37  ? -7.783  18.212  -5.178  1    29.472  ? 73   ILE   A N   1 
ATOM   270  C  CA  . ILE   A 1  37  ? -6.369  17.909  -5.252  1    28.948  ? 73   ILE   A CA  1 
ATOM   271  C  C   . ILE   A 1  37  ? -5.734  18.91   -4.293  1    33.574  ? 73   ILE   A C   1 
ATOM   272  O  O   . ILE   A 1  37  ? -5.873  20.113  -4.533  1    31.349  ? 73   ILE   A O   1 
ATOM   273  C  CB  . ILE   A 1  37  ? -5.859  18.141  -6.701  1    30.089  ? 73   ILE   A CB  1 
ATOM   274  C  CG1 . ILE   A 1  37  ? -6.744  17.376  -7.785  1    27.435  ? 73   ILE   A CG1 1 
ATOM   275  C  CG2 . ILE   A 1  37  ? -4.382  17.764  -6.834  1    37.779  ? 73   ILE   A CG2 1 
ATOM   276  C  CD1 . ILE   A 1  37  ? -6.27   17.502  -9.229  1    24.411  ? 73   ILE   A CD1 1 
ATOM   277  N  N   . THR   A 1  38  ? -5.197  18.44   -3.159  1    34.344  ? 74   THR   A N   1 
ATOM   278  C  CA  . THR   A 1  38  ? -4.519  19.298  -2.173  1    32.319  ? 74   THR   A CA  1 
ATOM   279  C  C   . THR   A 1  38  ? -3.276  18.541  -1.725  1    36.7    ? 74   THR   A C   1 
ATOM   280  O  O   . THR   A 1  38  ? -3.151  17.356  -2.019  1    28.762  ? 74   THR   A O   1 
ATOM   281  C  CB  . THR   A 1  38  ? -5.417  19.649  -0.979  1    31.99   ? 74   THR   A CB  1 
ATOM   282  O  OG1 . THR   A 1  38  ? -5.529  18.405  -0.276  1    36.816  ? 74   THR   A OG1 1 
ATOM   283  C  CG2 . THR   A 1  38  ? -6.729  20.345  -1.348  1    30.156  ? 74   THR   A CG2 1 
ATOM   284  N  N   . THR   A 1  39  ? -2.331  19.229  -1.055  1    36.244  ? 75   THR   A N   1 
ATOM   285  C  CA  . THR   A 1  39  ? -1.21   18.549  -0.399  1    35.174  ? 75   THR   A CA  1 
ATOM   286  C  C   . THR   A 1  39  ? -1.729  17.362  0.446   1    31.297  ? 75   THR   A C   1 
ATOM   287  O  O   . THR   A 1  39  ? -1.239  16.22   0.291   1    32.369  ? 75   THR   A O   1 
ATOM   288  C  CB  . THR   A 1  39  ? -0.305  19.53   0.378   1    37.611  ? 75   THR   A CB  1 
ATOM   289  O  OG1 . THR   A 1  39  ? 0.107   20.332  -0.722  1    38.046  ? 75   THR   A OG1 1 
ATOM   290  C  CG2 . THR   A 1  39  ? 1.029   18.94   0.834   1    42.537  ? 75   THR   A CG2 1 
ATOM   291  N  N   . GLU   A 1  40  ? -2.743  17.618  1.292   1    29.75   ? 76   GLU   A N   1 
ATOM   292  C  CA  . GLU   A 1  40  ? -3.227  16.657  2.284   1    32.925  ? 76   GLU   A CA  1 
ATOM   293  C  C   . GLU   A 1  40  ? -3.966  15.468  1.642   1    30.05   ? 76   GLU   A C   1 
ATOM   294  O  O   . GLU   A 1  40  ? -3.734  14.325  2.013   1    30.896  ? 76   GLU   A O   1 
ATOM   295  C  CB  . GLU   A 1  40  ? -4.123  17.363  3.293   1    35.781  ? 76   GLU   A CB  1 
ATOM   296  C  CG  . GLU   A 1  40  ? -4.62   16.418  4.382   1    44.273  ? 76   GLU   A CG  1 
ATOM   297  C  CD  . GLU   A 1  40  ? -5.451  17.2    5.391   1    70.305  ? 76   GLU   A CD  1 
ATOM   298  O  OE1 . GLU   A 1  40  ? -4.795  17.854  6.235   1    88.887  ? 76   GLU   A OE1 1 
ATOM   299  O  OE2 . GLU   A 1  40  ? -6.711  17.234  5.325   1    66.573  ? 76   GLU   A OE2 1 
ATOM   300  N  N   . THR   A 1  41  ? -4.867  15.725  0.683   1    29.503  ? 77   THR   A N   1 
ATOM   301  C  CA  . THR   A 1  41  ? -5.539  14.599  0.053   1    31.644  ? 77   THR   A CA  1 
ATOM   302  C  C   . THR   A 1  41  ? -4.474  13.746  -0.636  1    26.044  ? 77   THR   A C   1 
ATOM   303  O  O   . THR   A 1  41  ? -4.627  12.522  -0.648  1    34.05   ? 77   THR   A O   1 
ATOM   304  C  CB  . THR   A 1  41  ? -6.625  15.064  -0.921  1    28.035  ? 77   THR   A CB  1 
ATOM   305  O  OG1 . THR   A 1  41  ? -6.046  15.948  -1.875  1    31.602  ? 77   THR   A OG1 1 
ATOM   306  C  CG2 . THR   A 1  41  ? -7.717  15.861  -0.271  1    30.591  ? 77   THR   A CG2 1 
ATOM   307  N  N   . SER   A 1  42  ? -3.416  14.389  -1.226  1    26.893  ? 78   SER   A N   1 
ATOM   308  C  CA  . SER   A 1  42  ? -2.312  13.637  -1.852  1    30.276  ? 78   SER   A CA  1 
ATOM   309  C  C   . SER   A 1  42  ? -1.666  12.682  -0.851  1    37.515  ? 78   SER   A C   1 
ATOM   310  O  O   . SER   A 1  42  ? -1.448  11.494  -1.142  1    30.401  ? 78   SER   A O   1 
ATOM   311  C  CB  . SER   A 1  42  ? -1.234  14.521  -2.457  1    34.071  ? 78   SER   A CB  1 
ATOM   312  O  OG  . SER   A 1  42  ? -1.803  15.119  -3.625  1    43.734  ? 78   SER   A OG  1 
ATOM   313  N  N   . LYS   A 1  43  ? -1.297  13.262  0.309   1    37.607  ? 79   LYS   A N   1 
ATOM   314  C  CA  . LYS   A 1  43  ? -0.656  12.545  1.41    1    38.866  ? 79   LYS   A CA  1 
ATOM   315  C  C   . LYS   A 1  43  ? -1.458  11.328  1.852   1    32.064  ? 79   LYS   A C   1 
ATOM   316  O  O   . LYS   A 1  43  ? -0.903  10.243  1.855   1    37.541  ? 79   LYS   A O   1 
ATOM   317  C  CB  . LYS   A 1  43  ? -0.249  13.414  2.609   1    41.546  ? 79   LYS   A CB  1 
ATOM   318  C  CG  . LYS   A 1  43  ? 1.252   13.748  2.726   1    57.511  ? 79   LYS   A CG  1 
ATOM   319  C  CD  . LYS   A 1  43  ? 1.822   14.735  1.697   1    65.341  ? 79   LYS   A CD  1 
ATOM   320  C  CE  . LYS   A 1  43  ? 3.087   15.479  2.083   1    67.076  ? 79   LYS   A CE  1 
ATOM   321  N  NZ  . LYS   A 1  43  ? 2.866   16.597  3.007   1    56.617  ? 79   LYS   A NZ  1 
ATOM   322  N  N   . ILE   A 1  44  ? -2.763  11.51   2.187   1    32.665  ? 80   ILE   A N   1 
ATOM   323  C  CA  . ILE   A 1  44  ? -3.631  10.408  2.606   1    30.247  ? 80   ILE   A CA  1 
ATOM   324  C  C   . ILE   A 1  44  ? -3.708  9.358   1.486   1    31.995  ? 80   ILE   A C   1 
ATOM   325  O  O   . ILE   A 1  44  ? -3.6    8.161   1.717   1    37.525  ? 80   ILE   A O   1 
ATOM   326  C  CB  . ILE   A 1  44  ? -5.017  10.954  2.98    1    29.167  ? 80   ILE   A CB  1 
ATOM   327  C  CG1 . ILE   A 1  44  ? -4.939  11.97   4.159   1    34.185  ? 80   ILE   A CG1 1 
ATOM   328  C  CG2 . ILE   A 1  44  ? -6.004  9.831   3.25    1    28.888  ? 80   ILE   A CG2 1 
ATOM   329  C  CD1 . ILE   A 1  44  ? -6.303  12.472  4.63    1    28.291  ? 80   ILE   A CD1 1 
ATOM   330  N  N   . LEU   A 1  45  ? -3.923  9.797   0.245   1    26.876  ? 81   LEU   A N   1 
ATOM   331  C  CA  . LEU   A 1  45  ? -3.911  8.854   -0.864  1    24.805  ? 81   LEU   A CA  1 
ATOM   332  C  C   . LEU   A 1  45  ? -2.621  8.017   -0.843  1    25.621  ? 81   LEU   A C   1 
ATOM   333  O  O   . LEU   A 1  45  ? -2.69   6.809   -1.033  1    27.925  ? 81   LEU   A O   1 
ATOM   334  C  CB  . LEU   A 1  45  ? -4.076  9.537   -2.233  1    25.899  ? 81   LEU   A CB  1 
ATOM   335  C  CG  . LEU   A 1  45  ? -4.194  8.602   -3.455  1    24.057  ? 81   LEU   A CG  1 
ATOM   336  C  CD1 . LEU   A 1  45  ? -5.113  7.427   -3.219  1    21.679  ? 81   LEU   A CD1 1 
ATOM   337  C  CD2 . LEU   A 1  45  ? -4.582  9.393   -4.726  1    21.656  ? 81   LEU   A CD2 1 
ATOM   338  N  N   . LEU   A 1  46  ? -1.453  8.654   -0.776  1    25.693  ? 82   LEU   A N   1 
ATOM   339  C  CA  . LEU   A 1  46  ? -0.211  7.903   -0.94   1    29.469  ? 82   LEU   A CA  1 
ATOM   340  C  C   . LEU   A 1  46  ? -0.083  6.901   0.217   1    33.822  ? 82   LEU   A C   1 
ATOM   341  O  O   . LEU   A 1  46  ? 0.349   5.766   0.007   1    31.06   ? 82   LEU   A O   1 
ATOM   342  C  CB  . LEU   A 1  46  ? 1.053   8.753   -1.133  1    34.481  ? 82   LEU   A CB  1 
ATOM   343  C  CG  . LEU   A 1  46  ? 1.228   9.462   -2.494  1    37.321  ? 82   LEU   A CG  1 
ATOM   344  C  CD1 . LEU   A 1  46  ? 2.27    10.578  -2.428  1    35.461  ? 82   LEU   A CD1 1 
ATOM   345  C  CD2 . LEU   A 1  46  ? 1.546   8.498   -3.662  1    38.673  ? 82   LEU   A CD2 1 
ATOM   346  N  N   . GLN   A 1  47  ? -0.589  7.284   1.395   1    30.467  ? 83   GLN   A N   1 
ATOM   347  C  CA  . GLN   A 1  47  ? -0.638  6.383   2.546   1    36.825  ? 83   GLN   A CA  1 
ATOM   348  C  C   . GLN   A 1  47  ? -1.568  5.18    2.296   1    33.435  ? 83   GLN   A C   1 
ATOM   349  O  O   . GLN   A 1  47  ? -1.216  4.055   2.636   1    31.572  ? 83   GLN   A O   1 
ATOM   350  C  CB  . GLN   A 1  47  ? -0.996  7.173   3.821   1    39.258  ? 83   GLN   A CB  1 
ATOM   351  C  CG  . GLN   A 1  47  ? -1.07   6.281   5.067   1    45.883  ? 83   GLN   A CG  1 
ATOM   352  C  CD  . GLN   A 1  47  ? -2.466  5.787   5.45    1    61.088  ? 83   GLN   A CD  1 
ATOM   353  O  OE1 . GLN   A 1  47  ? -3.418  6.575   5.544   1    76.199  ? 83   GLN   A OE1 1 
ATOM   354  N  NE2 . GLN   A 1  47  ? -2.63   4.489   5.71    1    51.046  ? 83   GLN   A NE2 1 
ATOM   355  N  N   . LYS   A 1  48  ? -2.794  5.411   1.775   1    30.135  ? 84   LYS   A N   1 
ATOM   356  C  CA  . LYS   A 1  48  ? -3.699  4.309   1.506   1    30.007  ? 84   LYS   A CA  1 
ATOM   357  C  C   . LYS   A 1  48  ? -3.142  3.404   0.421   1    30.564  ? 84   LYS   A C   1 
ATOM   358  O  O   . LYS   A 1  48  ? -3.544  2.238   0.338   1    30.184  ? 84   LYS   A O   1 
ATOM   359  C  CB  . LYS   A 1  48  ? -5.066  4.817   1.047   1    33.812  ? 84   LYS   A CB  1 
ATOM   360  C  CG  . LYS   A 1  48  ? -5.761  5.588   2.142   1    39.121  ? 84   LYS   A CG  1 
ATOM   361  C  CD  . LYS   A 1  48  ? -6.335  4.648   3.178   1    40.8    ? 84   LYS   A CD  1 
ATOM   362  C  CE  . LYS   A 1  48  ? -6.953  5.46    4.25    1    44.754  ? 84   LYS   A CE  1 
ATOM   363  N  NZ  . LYS   A 1  48  ? -7.019  4.542   5.383   1    42.966  ? 84   LYS   A NZ  1 
ATOM   364  N  N   . ASN   A 1  49  ? -2.353  3.99    -0.49   1    30.189  ? 85   ASN   A N   1 
ATOM   365  C  CA  . ASN   A 1  49  ? -1.622  3.159   -1.441  1    33.765  ? 85   ASN   A CA  1 
ATOM   366  C  C   . ASN   A 1  49  ? -0.774  2.148   -0.68   1    33.014  ? 85   ASN   A C   1 
ATOM   367  O  O   . ASN   A 1  49  ? -0.717  0.999   -1.061  1    28.693  ? 85   ASN   A O   1 
ATOM   368  C  CB  . ASN   A 1  49  ? -0.619  3.909   -2.3    1    33.078  ? 85   ASN   A CB  1 
ATOM   369  C  CG  . ASN   A 1  49  ? -1.233  4.278   -3.63   1    42.253  ? 85   ASN   A CG  1 
ATOM   370  O  OD1 . ASN   A 1  49  ? -1.662  3.397   -4.394  1    43.759  ? 85   ASN   A OD1 1 
ATOM   371  N  ND2 . ASN   A 1  49  ? -1.278  5.566   -3.924  1    41.093  ? 85   ASN   A ND2 1 
ATOM   372  N  N   . MET   A 1  50  ? -0.053  2.577   0.348   1    25.939  ? 86   MET   A N   1 
ATOM   373  C  CA  . MET   A 1  50  ? 0.812   1.594   0.978   1    28.263  ? 86   MET   A CA  1 
ATOM   374  C  C   . MET   A 1  50  ? -0.098  0.592   1.674   1    28.359  ? 86   MET   A C   1 
ATOM   375  O  O   . MET   A 1  50  ? 0.227   -0.586  1.767   1    24.526  ? 86   MET   A O   1 
ATOM   376  C  CB  . MET   A 1  50  ? 1.721   2.224   2.046   1    33.82   ? 86   MET   A CB  1 
ATOM   377  C  CG  . MET   A 1  50  ? 3.029   2.878   1.533   1    40.273  ? 86   MET   A CG  1 
ATOM   378  S  SD  . MET   A 1  50  ? 3.563   4.046   2.823   1    72.641  ? 86   MET   A SD  1 
ATOM   379  C  CE  . MET   A 1  50  ? 3.061   5.766   2.573   1    55.29   ? 86   MET   A CE  1 
ATOM   380  N  N   . GLN   A 1  51  ? -1.273  1.03    2.14    1    29.822  ? 87   GLN   A N   1 
ATOM   381  C  CA  . GLN   A 1  51  ? -2.114  0.084   2.861   1    33.19   ? 87   GLN   A CA  1 
ATOM   382  C  C   . GLN   A 1  51  ? -2.686  -0.995  1.943   1    31.925  ? 87   GLN   A C   1 
ATOM   383  O  O   . GLN   A 1  51  ? -2.805  -2.169  2.311   1    27.006  ? 87   GLN   A O   1 
ATOM   384  C  CB  . GLN   A 1  51  ? -3.267  0.824   3.539   1    35.786  ? 87   GLN   A CB  1 
ATOM   385  C  CG  . GLN   A 1  51  ? -4.387  -0.074  4.088   1    38.71   ? 87   GLN   A CG  1 
ATOM   386  C  CD  . GLN   A 1  51  ? -5.546  0.743   4.649   1    57.028  ? 87   GLN   A CD  1 
ATOM   387  O  OE1 . GLN   A 1  51  ? -5.327  1.819   5.224   1    71.05   ? 87   GLN   A OE1 1 
ATOM   388  N  NE2 . GLN   A 1  51  ? -6.788  0.309   4.434   1    52.191  ? 87   GLN   A NE2 1 
ATOM   389  N  N   . ILE   A 1  52  ? -3.177  -0.583  0.776   1    25.56   ? 88   ILE   A N   1 
ATOM   390  C  CA  . ILE   A 1  52  ? -3.729  -1.626  -0.082  1    31.608  ? 88   ILE   A CA  1 
ATOM   391  C  C   . ILE   A 1  52  ? -2.596  -2.552  -0.588  1    26.337  ? 88   ILE   A C   1 
ATOM   392  O  O   . ILE   A 1  52  ? -2.788  -3.761  -0.811  1    24.572  ? 88   ILE   A O   1 
ATOM   393  C  CB  . ILE   A 1  52  ? -4.587  -0.972  -1.176  1    32.021  ? 88   ILE   A CB  1 
ATOM   394  C  CG1 . ILE   A 1  52  ? -5.323  -1.967  -2.004  1    30.984  ? 88   ILE   A CG1 1 
ATOM   395  C  CG2 . ILE   A 1  52  ? -3.725  -0.085  -2.061  1    31.072  ? 88   ILE   A CG2 1 
ATOM   396  C  CD1 . ILE   A 1  52  ? -6.553  -1.341  -2.623  1    39.428  ? 88   ILE   A CD1 1 
ATOM   397  N  N   . ALA   A 1  53  ? -1.384  -2.003  -0.752  1    26.74   ? 89   ALA   A N   1 
ATOM   398  C  CA  . ALA   A 1  53  ? -0.26   -2.808  -1.238  1    24.457  ? 89   ALA   A CA  1 
ATOM   399  C  C   . ALA   A 1  53  ? 0.09    -3.878  -0.185  1    27.923  ? 89   ALA   A C   1 
ATOM   400  O  O   . ALA   A 1  53  ? 0.259   -5.053  -0.498  1    22.387  ? 89   ALA   A O   1 
ATOM   401  C  CB  . ALA   A 1  53  ? 0.914   -1.875  -1.494  1    29.946  ? 89   ALA   A CB  1 
ATOM   402  N  N   . GLN   A 1  54  ? 0.06    -3.498  1.105   1    28.389  ? 90   GLN   A N   1 
ATOM   403  C  CA  . GLN   A 1  54  ? 0.288   -4.508  2.137   1    30.032  ? 90   GLN   A CA  1 
ATOM   404  C  C   . GLN   A 1  54  ? -0.736  -5.638  2.073   1    26.82   ? 90   GLN   A C   1 
ATOM   405  O  O   . GLN   A 1  54  ? -0.324  -6.8    2.199   1    30.5    ? 90   GLN   A O   1 
ATOM   406  C  CB  . GLN   A 1  54  ? 0.178   -3.989  3.571   1    36.688  ? 90   GLN   A CB  1 
ATOM   407  C  CG  . GLN   A 1  54  ? 1.248   -2.998  3.996   1    56.756  ? 90   GLN   A CG  1 
ATOM   408  C  CD  . GLN   A 1  54  ? 0.853   -2.402  5.334   1    74.287  ? 90   GLN   A CD  1 
ATOM   409  O  OE1 . GLN   A 1  54  ? 0.588   -3.134  6.302   1    76.986  ? 90   GLN   A OE1 1 
ATOM   410  N  NE2 . GLN   A 1  54  ? 0.718   -1.079  5.374   1    60.767  ? 90   GLN   A NE2 1 
ATOM   411  N  N   . HIS   A 1  55  ? -2.044  -5.303  1.911   1    22.693  ? 91   HIS   A N   1 
ATOM   412  C  CA  . HIS   A 1  55  ? -3.096  -6.298  1.729   1    21.315  ? 91   HIS   A CA  1 
ATOM   413  C  C   . HIS   A 1  55  ? -2.786  -7.194  0.537   1    23.739  ? 91   HIS   A C   1 
ATOM   414  O  O   . HIS   A 1  55  ? -2.772  -8.465  0.652   1    24.748  ? 91   HIS   A O   1 
ATOM   415  C  CB  . HIS   A 1  55  ? -4.456  -5.581  1.568   1    22.948  ? 91   HIS   A CB  1 
ATOM   416  C  CG  . HIS   A 1  55  ? -5.548  -6.519  1.136   1    22.68   ? 91   HIS   A CG  1 
ATOM   417  N  ND1 . HIS   A 1  55  ? -6.256  -7.33   2.02    1    28.912  ? 91   HIS   A ND1 1 
ATOM   418  C  CD2 . HIS   A 1  55  ? -6.058  -6.787  -0.085  1    21.6    ? 91   HIS   A CD2 1 
ATOM   419  C  CE1 . HIS   A 1  55  ? -7.174  -8.069  1.39    1    22.151  ? 91   HIS   A CE1 1 
ATOM   420  N  NE2 . HIS   A 1  55  ? -7.056  -7.777  0.093   1    27.314  ? 91   HIS   A NE2 1 
ATOM   421  N  N   . THR   A 1  56  ? -2.466  -6.508  -0.609  1    21.715  ? 92   THR   A N   1 
ATOM   422  C  CA  . THR   A 1  56  ? -2.256  -7.283  -1.834  1    23.999  ? 92   THR   A CA  1 
ATOM   423  C  C   . THR   A 1  56  ? -1.104  -8.281  -1.617  1    23.808  ? 92   THR   A C   1 
ATOM   424  O  O   . THR   A 1  56  ? -1.212  -9.467  -1.951  1    26.118  ? 92   THR   A O   1 
ATOM   425  C  CB  . THR   A 1  56  ? -1.935  -6.282  -2.948  1    27.48   ? 92   THR   A CB  1 
ATOM   426  O  OG1 . THR   A 1  56  ? -3.009  -5.354  -3.088  1    23.859  ? 92   THR   A OG1 1 
ATOM   427  C  CG2 . THR   A 1  56  ? -1.809  -6.973  -4.296  1    29.311  ? 92   THR   A CG2 1 
ATOM   428  N  N   . LEU   A 1  57  ? 0.012   -7.798  -1.005  1    27.436  ? 93   LEU   A N   1 
ATOM   429  C  CA  . LEU   A 1  57  ? 1.193   -8.622  -0.723  1    30.738  ? 93   LEU   A CA  1 
ATOM   430  C  C   . LEU   A 1  57  ? 0.828   -9.809  0.171   1    24.448  ? 93   LEU   A C   1 
ATOM   431  O  O   . LEU   A 1  57  ? 1.163   -10.94  -0.13   1    30.598  ? 93   LEU   A O   1 
ATOM   432  C  CB  . LEU   A 1  57  ? 2.252   -7.737  -0.054  1    30.32   ? 93   LEU   A CB  1 
ATOM   433  C  CG  . LEU   A 1  57  ? 3.659   -8.312  0.05    1    30.422  ? 93   LEU   A CG  1 
ATOM   434  C  CD1 . LEU   A 1  57  ? 4.177   -8.811  -1.348  1    33.315  ? 93   LEU   A CD1 1 
ATOM   435  C  CD2 . LEU   A 1  57  ? 4.527   -7.163  0.659   1    26.01   ? 93   LEU   A CD2 1 
ATOM   436  N  N   . LYS   A 1  58  ? 0.063   -9.545  1.228   1    26.207  ? 94   LYS   A N   1 
ATOM   437  C  CA  . LYS   A 1  58  ? -0.281  -10.594 2.164   1    24.004  ? 94   LYS   A CA  1 
ATOM   438  C  C   . LYS   A 1  58  ? -1.047  -11.676 1.413   1    24.737  ? 94   LYS   A C   1 
ATOM   439  O  O   . LYS   A 1  58  ? -0.721  -12.871 1.499   1    26.004  ? 94   LYS   A O   1 
ATOM   440  C  CB  . LYS   A 1  58  ? -1.201  -10.032 3.252   1    28.948  ? 94   LYS   A CB  1 
ATOM   441  C  CG  . LYS   A 1  58  ? -1.719  -11.089 4.273   1    25.446  ? 94   LYS   A CG  1 
ATOM   442  C  CD  . LYS   A 1  58  ? -2.432  -10.427 5.471   1    34.716  ? 94   LYS   A CD  1 
ATOM   443  C  CE  . LYS   A 1  58  ? -3.053  -11.367 6.491   1    40.119  ? 94   LYS   A CE  1 
ATOM   444  N  NZ  . LYS   A 1  58  ? -3.766  -10.641 7.562   1    36.928  ? 94   LYS   A NZ  1 
ATOM   445  N  N   . TYR   A 1  59  ? -2.139  -11.284 0.744   1    23.133  ? 95   TYR   A N   1 
ATOM   446  C  CA  . TYR   A 1  59  ? -2.991  -12.29  0.115   1    23.353  ? 95   TYR   A CA  1 
ATOM   447  C  C   . TYR   A 1  59  ? -2.349  -12.867 -1.152  1    25.272  ? 95   TYR   A C   1 
ATOM   448  O  O   . TYR   A 1  59  ? -2.563  -14.045 -1.431  1    24.474  ? 95   TYR   A O   1 
ATOM   449  C  CB  . TYR   A 1  59  ? -4.399  -11.823 -0.236  1    25.109  ? 95   TYR   A CB  1 
ATOM   450  C  CG  . TYR   A 1  59  ? -5.168  -11.826 1.086   1    29.913  ? 95   TYR   A CG  1 
ATOM   451  C  CD1 . TYR   A 1  59  ? -5.872  -12.956 1.521   1    28.658  ? 95   TYR   A CD1 1 
ATOM   452  C  CD2 . TYR   A 1  59  ? -5.087  -10.724 1.933   1    28.655  ? 95   TYR   A CD2 1 
ATOM   453  C  CE1 . TYR   A 1  59  ? -6.484  -12.975 2.776   1    36.531  ? 95   TYR   A CE1 1 
ATOM   454  C  CE2 . TYR   A 1  59  ? -5.698  -10.719 3.184   1    30.732  ? 95   TYR   A CE2 1 
ATOM   455  C  CZ  . TYR   A 1  59  ? -6.358  -11.868 3.616   1    30.58   ? 95   TYR   A CZ  1 
ATOM   456  O  OH  . TYR   A 1  59  ? -6.893  -11.77  4.851   1    29.224  ? 95   TYR   A OH  1 
ATOM   457  N  N   . GLY   A 1  60  ? -1.612  -12.037 -1.91   1    24.003  ? 96   GLY   A N   1 
ATOM   458  C  CA  . GLY   A 1  60  ? -0.931  -12.529 -3.102  1    22.364  ? 96   GLY   A CA  1 
ATOM   459  C  C   . GLY   A 1  60  ? 0.177   -13.52  -2.729  1    27.399  ? 96   GLY   A C   1 
ATOM   460  O  O   . GLY   A 1  60  ? 0.34    -14.538 -3.4    1    27.009  ? 96   GLY   A O   1 
ATOM   461  N  N   . THR   A 1  61  ? 0.924   -13.252 -1.654  1    25.986  ? 97   THR   A N   1 
ATOM   462  C  CA  . THR   A 1  61  ? 1.911   -14.245 -1.221  1    27.6    ? 97   THR   A CA  1 
ATOM   463  C  C   . THR   A 1  61  ? 1.249   -15.593 -0.913  1    29.689  ? 97   THR   A C   1 
ATOM   464  O  O   . THR   A 1  61  ? 1.765   -16.649 -1.303  1    34.152  ? 97   THR   A O   1 
ATOM   465  C  CB  . THR   A 1  61  ? 2.67    -13.74  -0.011  1    28.283  ? 97   THR   A CB  1 
ATOM   466  O  OG1 . THR   A 1  61  ? 3.328   -12.574 -0.522  1    27.754  ? 97   THR   A OG1 1 
ATOM   467  C  CG2 . THR   A 1  61  ? 3.601   -14.811 0.55    1    28.088  ? 97   THR   A CG2 1 
ATOM   468  N  N   . GLN   A 1  62  ? 0.121   -15.561 -0.179  1    32.605  ? 98   GLN   A N   1 
ATOM   469  C  CA  . GLN   A 1  62  ? -0.587  -16.773 0.242   1    36.517  ? 98   GLN   A CA  1 
ATOM   470  C  C   . GLN   A 1  62  ? -1.143  -17.45  -0.995  1    31.031  ? 98   GLN   A C   1 
ATOM   471  O  O   . GLN   A 1  62  ? -1.014  -18.662 -1.097  1    32.835  ? 98   GLN   A O   1 
ATOM   472  C  CB  . GLN   A 1  62  ? -1.861  -16.631 1.091   1    36.702  ? 98   GLN   A CB  1 
ATOM   473  C  CG  . GLN   A 1  62  ? -1.656  -16.161 2.529   1    60.974  ? 98   GLN   A CG  1 
ATOM   474  C  CD  . GLN   A 1  62  ? -2.87   -16.358 3.426   1    65.471  ? 98   GLN   A CD  1 
ATOM   475  O  OE1 . GLN   A 1  62  ? -3.349  -17.49  3.584   1    76.689  ? 98   GLN   A OE1 1 
ATOM   476  N  NE2 . GLN   A 1  62  ? -3.356  -15.283 4.051   1    56.285  ? 98   GLN   A NE2 1 
ATOM   477  N  N   . ALA   A 1  63  ? -1.723  -16.65  -1.917  1    28.937  ? 99   ALA   A N   1 
ATOM   478  C  CA  . ALA   A 1  63  ? -2.326  -17.196 -3.148  1    29.898  ? 99   ALA   A CA  1 
ATOM   479  C  C   . ALA   A 1  63  ? -1.31   -18.022 -3.951  1    24.983  ? 99   ALA   A C   1 
ATOM   480  O  O   . ALA   A 1  63  ? -1.616  -19.045 -4.542  1    27.473  ? 99   ALA   A O   1 
ATOM   481  C  CB  . ALA   A 1  63  ? -2.944  -16.081 -3.993  1    27.845  ? 99   ALA   A CB  1 
ATOM   482  N  N   . ARG   A 1  64  ? -0.067  -17.566 -3.989  1    26.092  ? 100  ARG   A N   1 
ATOM   483  C  CA  . ARG   A 1  64  ? 0.933   -18.216 -4.797  1    28.426  ? 100  ARG   A CA  1 
ATOM   484  C  C   . ARG   A 1  64  ? 1.371   -19.554 -4.19   1    34.58   ? 100  ARG   A C   1 
ATOM   485  O  O   . ARG   A 1  64  ? 2.012   -20.31  -4.87   1    32.104  ? 100  ARG   A O   1 
ATOM   486  C  CB  . ARG   A 1  64  ? 2.191   -17.343 -4.865  1    26.977  ? 100  ARG   A CB  1 
ATOM   487  C  CG  . ARG   A 1  64  ? 1.947   -16.31  -5.954  1    26.564  ? 100  ARG   A CG  1 
ATOM   488  C  CD  . ARG   A 1  64  ? 3.075   -15.285 -5.803  1    31.749  ? 100  ARG   A CD  1 
ATOM   489  N  NE  . ARG   A 1  64  ? 2.921   -14.181 -6.757  1    27.261  ? 100  ARG   A NE  1 
ATOM   490  C  CZ  . ARG   A 1  64  ? 3.912   -13.333 -7.074  1    34.203  ? 100  ARG   A CZ  1 
ATOM   491  N  NH1 . ARG   A 1  64  ? 5.125   -13.588 -6.578  1    26.103  ? 100  ARG   A NH1 1 
ATOM   492  N  NH2 . ARG   A 1  64  ? 3.706   -12.259 -7.884  1    25.821  ? 100  ARG   A NH2 1 
ATOM   493  N  N   . LYS   A 1  65  ? 1.075   -19.837 -2.919  1    36.761  ? 101  LYS   A N   1 
ATOM   494  C  CA  . LYS   A 1  65  ? 1.447   -21.126 -2.367  1    41.049  ? 101  LYS   A CA  1 
ATOM   495  C  C   . LYS   A 1  65  ? 0.427   -22.167 -2.804  1    35.188  ? 101  LYS   A C   1 
ATOM   496  O  O   . LYS   A 1  65  ? 0.63    -23.332 -2.569  1    47.141  ? 101  LYS   A O   1 
ATOM   497  C  CB  . LYS   A 1  65  ? 1.543   -21.039 -0.839  1    41.517  ? 101  LYS   A CB  1 
ATOM   498  C  CG  . LYS   A 1  65  ? 2.567   -20.029 -0.31   1    56.667  ? 101  LYS   A CG  1 
ATOM   499  C  CD  . LYS   A 1  65  ? 2.845   -20.009 1.192   1    59.515  ? 101  LYS   A CD  1 
ATOM   500  C  CE  . LYS   A 1  65  ? 1.74    -19.488 2.081   1    93.516  ? 101  LYS   A CE  1 
ATOM   501  N  NZ  . LYS   A 1  65  ? 1.773   -18.034 2.291   1    96.146  ? 101  LYS   A NZ  1 
ATOM   502  N  N   . PHE   A 1  66  ? -0.694  -21.782 -3.409  1    30.325  ? 102  PHE   A N   1 
ATOM   503  C  CA  . PHE   A 1  66  ? -1.592  -22.802 -3.914  1    36.819  ? 102  PHE   A CA  1 
ATOM   504  C  C   . PHE   A 1  66  ? -1.22   -23.199 -5.329  1    46.172  ? 102  PHE   A C   1 
ATOM   505  O  O   . PHE   A 1  66  ? -1.203  -22.342 -6.204  1    49.744  ? 102  PHE   A O   1 
ATOM   506  C  CB  . PHE   A 1  66  ? -3.046  -22.371 -4.079  1    38.841  ? 102  PHE   A CB  1 
ATOM   507  C  CG  . PHE   A 1  66  ? -3.74   -22.087 -2.75   1    39.51   ? 102  PHE   A CG  1 
ATOM   508  C  CD1 . PHE   A 1  66  ? -4.35   -23.122 -2.044  1    42.063  ? 102  PHE   A CD1 1 
ATOM   509  C  CD2 . PHE   A 1  66  ? -3.732  -20.808 -2.196  1    39.27   ? 102  PHE   A CD2 1 
ATOM   510  C  CE1 . PHE   A 1  66  ? -4.975  -22.869 -0.823  1    44.166  ? 102  PHE   A CE1 1 
ATOM   511  C  CE2 . PHE   A 1  66  ? -4.359  -20.553 -0.983  1    38.855  ? 102  PHE   A CE2 1 
ATOM   512  C  CZ  . PHE   A 1  66  ? -4.949  -21.599 -0.285  1    50.467  ? 102  PHE   A CZ  1 
ATOM   513  N  N   . ASP   A 1  67  ? -1.053  -24.506 -5.555  1    44.557  ? 103  ASP   A N   1 
ATOM   514  C  CA  . ASP   A 1  67  ? -0.922  -25.013 -6.913  1    41.716  ? 103  ASP   A CA  1 
ATOM   515  C  C   . ASP   A 1  67  ? -2.3    -25.121 -7.547  1    39.853  ? 103  ASP   A C   1 
ATOM   516  O  O   . ASP   A 1  67  ? -3.054  -26.082 -7.319  1    39.766  ? 103  ASP   A O   1 
ATOM   517  C  CB  . ASP   A 1  67  ? -0.23   -26.367 -6.952  1    44.482  ? 103  ASP   A CB  1 
ATOM   518  C  CG  . ASP   A 1  67  ? 0.017   -26.942 -8.349  1    43.964  ? 103  ASP   A CG  1 
ATOM   519  O  OD1 . ASP   A 1  67  ? -0.441  -26.349 -9.361  1    37.245  ? 103  ASP   A OD1 1 
ATOM   520  O  OD2 . ASP   A 1  67  ? 0.689   -27.996 -8.424  1    53.515  ? 103  ASP   A OD2 1 
ATOM   521  N  N   . VAL   A 1  68  ? -2.603  -24.176 -8.438  1    34.571  ? 104  VAL   A N   1 
ATOM   522  C  CA  . VAL   A 1  68  ? -3.959  -24.121 -8.934  1    33.056  ? 104  VAL   A CA  1 
ATOM   523  C  C   . VAL   A 1  68  ? -4.164  -25.235 -9.963  1    36.211  ? 104  VAL   A C   1 
ATOM   524  O  O   . VAL   A 1  68  ? -5.296  -25.508 -10.332 1    40.79   ? 104  VAL   A O   1 
ATOM   525  C  CB  . VAL   A 1  68  ? -4.245  -22.738 -9.544  1    37.694  ? 104  VAL   A CB  1 
ATOM   526  C  CG1 . VAL   A 1  68  ? -3.564  -21.656 -8.751  1    39.063  ? 104  VAL   A CG1 1 
ATOM   527  C  CG2 . VAL   A 1  68  ? -3.817  -22.651 -11.007 1    49.707  ? 104  VAL   A CG2 1 
ATOM   528  N  N   . ASN   A 1  69  ? -3.063  -25.802 -10.499 1    36.899  ? 105  ASN   A N   1 
ATOM   529  C  CA  . ASN   A 1  69  ? -3.19   -27.002 -11.323 1    47.985  ? 105  ASN   A CA  1 
ATOM   530  C  C   . ASN   A 1  69  ? -4.009  -28.057 -10.6   1    54.427  ? 105  ASN   A C   1 
ATOM   531  O  O   . ASN   A 1  69  ? -4.849  -28.663 -11.249 1    56.737  ? 105  ASN   A O   1 
ATOM   532  C  CB  . ASN   A 1  69  ? -1.864  -27.636 -11.749 1    49.334  ? 105  ASN   A CB  1 
ATOM   533  C  CG  . ASN   A 1  69  ? -1.118  -26.67  -12.634 1    51.597  ? 105  ASN   A CG  1 
ATOM   534  O  OD1 . ASN   A 1  69  ? -1.739  -26.123 -13.562 1    42.389  ? 105  ASN   A OD1 1 
ATOM   535  N  ND2 . ASN   A 1  69  ? 0.12    -26.34  -12.257 1    42.318  ? 105  ASN   A ND2 1 
ATOM   536  N  N   . GLN   A 1  70  ? -3.75   -28.214 -9.282  1    48.913  ? 106  GLN   A N   1 
ATOM   537  C  CA  . GLN   A 1  70  ? -4.257  -29.278 -8.437  1    52.275  ? 106  GLN   A CA  1 
ATOM   538  C  C   . GLN   A 1  70  ? -5.635  -28.948 -7.86   1    56.714  ? 106  GLN   A C   1 
ATOM   539  O  O   . GLN   A 1  70  ? -6.071  -29.669 -6.974  1    57.383  ? 106  GLN   A O   1 
ATOM   540  C  CB  . GLN   A 1  70  ? -3.302  -29.385 -7.243  1    67.627  ? 106  GLN   A CB  1 
ATOM   541  C  CG  . GLN   A 1  70  ? -1.877  -29.806 -7.594  1    67.164  ? 106  GLN   A CG  1 
ATOM   542  C  CD  . GLN   A 1  70  ? -1.84   -31.078 -8.41   1    69.915  ? 106  GLN   A CD  1 
ATOM   543  O  OE1 . GLN   A 1  70  ? -2.494  -32.066 -8.06   1    83.405  ? 106  GLN   A OE1 1 
ATOM   544  N  NE2 . GLN   A 1  70  ? -1.123  -31.059 -9.527  1    69.324  ? 106  GLN   A NE2 1 
ATOM   545  N  N   . LEU   A 1  71  ? -6.302  -27.879 -8.333  1    53.623  ? 107  LEU   A N   1 
ATOM   546  C  CA  . LEU   A 1  71  ? -7.581  -27.425 -7.787  1    50.081  ? 107  LEU   A CA  1 
ATOM   547  C  C   . LEU   A 1  71  ? -8.674  -27.77  -8.781  1    50.526  ? 107  LEU   A C   1 
ATOM   548  O  O   . LEU   A 1  71  ? -8.587  -27.369 -9.942  1    54.272  ? 107  LEU   A O   1 
ATOM   549  C  CB  . LEU   A 1  71  ? -7.716  -25.936 -7.428  1    39.932  ? 107  LEU   A CB  1 
ATOM   550  C  CG  . LEU   A 1  71  ? -6.79   -25.378 -6.334  1    46.587  ? 107  LEU   A CG  1 
ATOM   551  C  CD1 . LEU   A 1  71  ? -6.971  -23.866 -6.127  1    46.05   ? 107  LEU   A CD1 1 
ATOM   552  C  CD2 . LEU   A 1  71  ? -6.996  -26.124 -5.034  1    41.341  ? 107  LEU   A CD2 1 
ATOM   553  N  N   . GLN   A 1  72  ? -9.747  -28.365 -8.242  1    45.285  ? 108  GLN   A N   1 
ATOM   554  C  CA  . GLN   A 1  72  ? -10.942 -28.833 -8.937  1    43.646  ? 108  GLN   A CA  1 
ATOM   555  C  C   . GLN   A 1  72  ? -11.908 -27.686 -9.265  1    47.459  ? 108  GLN   A C   1 
ATOM   556  O  O   . GLN   A 1  72  ? -12.288 -27.492 -10.42  1    40.511  ? 108  GLN   A O   1 
ATOM   557  C  CB  . GLN   A 1  72  ? -11.582 -29.804 -7.947  1    54.352  ? 108  GLN   A CB  1 
ATOM   558  C  CG  . GLN   A 1  72  ? -10.791 -31.085 -7.709  1    67.994  ? 108  GLN   A CG  1 
ATOM   559  C  CD  . GLN   A 1  72  ? -10.929 -31.989 -8.914  1    96.403  ? 108  GLN   A CD  1 
ATOM   560  O  OE1 . GLN   A 1  72  ? -12.041 -32.393 -9.28   1    101.122 ? 108  GLN   A OE1 1 
ATOM   561  N  NE2 . GLN   A 1  72  ? -9.816  -32.247 -9.59   1    97.646  ? 108  GLN   A NE2 1 
ATOM   562  N  N   . ASN   A 1  73  ? -12.405 -26.966 -8.243  1    49.448  ? 109  ASN   A N   1 
ATOM   563  C  CA  . ASN   A 1  73  ? -13.417 -25.938 -8.5    1    50.176  ? 109  ASN   A CA  1 
ATOM   564  C  C   . ASN   A 1  73  ? -12.833 -24.856 -9.415  1    39.191  ? 109  ASN   A C   1 
ATOM   565  O  O   . ASN   A 1  73  ? -11.807 -24.253 -9.066  1    40.431  ? 109  ASN   A O   1 
ATOM   566  C  CB  . ASN   A 1  73  ? -13.954 -25.279 -7.226  1    39.855  ? 109  ASN   A CB  1 
ATOM   567  C  CG  . ASN   A 1  73  ? -15.046 -24.298 -7.585  1    40.659  ? 109  ASN   A CG  1 
ATOM   568  O  OD1 . ASN   A 1  73  ? -14.791 -23.265 -8.217  1    44.025  ? 109  ASN   A OD1 1 
ATOM   569  N  ND2 . ASN   A 1  73  ? -16.29  -24.603 -7.248  1    41.568  ? 109  ASN   A ND2 1 
ATOM   570  N  N   . THR   A 1  74  ? -13.49  -24.553 -10.539 1    34.404  ? 110  THR   A N   1 
ATOM   571  C  CA  . THR   A 1  74  ? -12.842 -23.705 -11.542 1    37.975  ? 110  THR   A CA  1 
ATOM   572  C  C   . THR   A 1  74  ? -12.925 -22.199 -11.151 1    38.332  ? 110  THR   A C   1 
ATOM   573  O  O   . THR   A 1  74  ? -12.055 -21.41  -11.51  1    41.024  ? 110  THR   A O   1 
ATOM   574  C  CB  . THR   A 1  74  ? -13.237 -23.999 -13.008 1    39.936  ? 110  THR   A CB  1 
ATOM   575  O  OG1 . THR   A 1  74  ? -14.628 -23.744 -12.962 1    41.835  ? 110  THR   A OG1 1 
ATOM   576  C  CG2 . THR   A 1  74  ? -13.026 -25.423 -13.52  1    32.113  ? 110  THR   A CG2 1 
ATOM   577  N  N   . THR   A 1  75  ? -13.985 -21.765 -10.467 1    35.226  ? 111  THR   A N   1 
ATOM   578  C  CA  . THR   A 1  75  ? -14.141 -20.416 -9.942  1    35.912  ? 111  THR   A CA  1 
ATOM   579  C  C   . THR   A 1  75  ? -13.068 -20.13  -8.882  1    37.075  ? 111  THR   A C   1 
ATOM   580  O  O   . THR   A 1  75  ? -12.456 -19.069 -8.89   1    37.202  ? 111  THR   A O   1 
ATOM   581  C  CB  . THR   A 1  75  ? -15.555 -20.197 -9.39   1    33.521  ? 111  THR   A CB  1 
ATOM   582  O  OG1 . THR   A 1  75  ? -16.435 -20.328 -10.492 1    33.706  ? 111  THR   A OG1 1 
ATOM   583  C  CG2 . THR   A 1  75  ? -15.727 -18.828 -8.77   1    32.388  ? 111  THR   A CG2 1 
ATOM   584  N  N   . ILE   A 1  76  ? -12.854 -21.06  -7.939  1    33.712  ? 112  ILE   A N   1 
ATOM   585  C  CA  . ILE   A 1  76  ? -11.805 -20.895 -6.952  1    34.058  ? 112  ILE   A CA  1 
ATOM   586  C  C   . ILE   A 1  76  ? -10.417 -20.853 -7.618  1    40.993  ? 112  ILE   A C   1 
ATOM   587  O  O   . ILE   A 1  76  ? -9.641  -19.915 -7.371  1    35.703  ? 112  ILE   A O   1 
ATOM   588  C  CB  . ILE   A 1  76  ? -12.039 -21.935 -5.837  1    41.188  ? 112  ILE   A CB  1 
ATOM   589  C  CG1 . ILE   A 1  76  ? -13.22  -21.447 -4.946  1    40.212  ? 112  ILE   A CG1 1 
ATOM   590  C  CG2 . ILE   A 1  76  ? -10.78  -22.277 -5.04   1    37.846  ? 112  ILE   A CG2 1 
ATOM   591  C  CD1 . ILE   A 1  76  ? -13.905 -22.538 -4.149  1    56.405  ? 112  ILE   A CD1 1 
ATOM   592  N  N   . LYS   A 1  77  ? -10.112 -21.824 -8.506  1    33.458  ? 113  LYS   A N   1 
ATOM   593  C  CA  . LYS   A 1  77  ? -8.958  -21.786 -9.404  1    33.103  ? 113  LYS   A CA  1 
ATOM   594  C  C   . LYS   A 1  77  ? -8.727  -20.382 -9.991  1    26.995  ? 113  LYS   A C   1 
ATOM   595  O  O   . LYS   A 1  77  ? -7.604  -19.821 -10.011 1    29.469  ? 113  LYS   A O   1 
ATOM   596  C  CB  . LYS   A 1  77  ? -9.234  -22.743 -10.584 1    37.37   ? 113  LYS   A CB  1 
ATOM   597  C  CG  . LYS   A 1  77  ? -7.986  -23.438 -11.112 1    48.934  ? 113  LYS   A CG  1 
ATOM   598  C  CD  . LYS   A 1  77  ? -8.157  -24.56  -12.129 1    58.47   ? 113  LYS   A CD  1 
ATOM   599  C  CE  . LYS   A 1  77  ? -6.893  -24.665 -12.967 1    68.536  ? 113  LYS   A CE  1 
ATOM   600  N  NZ  . LYS   A 1  77  ? -6.384  -26.029 -13.181 1    68.321  ? 113  LYS   A NZ  1 
ATOM   601  N  N   . ARG   A 1  78  ? -9.792  -19.835 -10.58  1    27.489  ? 114  ARG   A N   1 
ATOM   602  C  CA  . ARG   A 1  78  ? -9.593  -18.613 -11.325 1    28.511  ? 114  ARG   A CA  1 
ATOM   603  C  C   . ARG   A 1  78  ? -9.365  -17.422 -10.392 1    34.352  ? 114  ARG   A C   1 
ATOM   604  O  O   . ARG   A 1  78  ? -8.571  -16.533 -10.699 1    29.486  ? 114  ARG   A O   1 
ATOM   605  C  CB  . ARG   A 1  78  ? -10.892 -18.494 -12.093 1    26.909  ? 114  ARG   A CB  1 
ATOM   606  C  CG  . ARG   A 1  78  ? -11.095 -17.232 -12.931 1    26.547  ? 114  ARG   A CG  1 
ATOM   607  C  CD  . ARG   A 1  78  ? -12.286 -17.355 -13.92  1    30.442  ? 114  ARG   A CD  1 
ATOM   608  N  NE  . ARG   A 1  78  ? -12.635 -16.138 -14.7   1    32.235  ? 114  ARG   A NE  1 
ATOM   609  C  CZ  . ARG   A 1  78  ? -11.991 -15.824 -15.833 1    35.517  ? 114  ARG   A CZ  1 
ATOM   610  N  NH1 . ARG   A 1  78  ? -11.117 -16.679 -16.306 1    35.98   ? 114  ARG   A NH1 1 
ATOM   611  N  NH2 . ARG   A 1  78  ? -12.228 -14.698 -16.505 1    30.066  ? 114  ARG   A NH2 1 
ATOM   612  N  N   . ILE   A 1  79  ? -10.121 -17.345 -9.28   1    30.991  ? 115  ILE   A N   1 
ATOM   613  C  CA  . ILE   A 1  79  ? -9.864  -16.269 -8.332  1    29.526  ? 115  ILE   A CA  1 
ATOM   614  C  C   . ILE   A 1  79  ? -8.418  -16.322 -7.875  1    24.505  ? 115  ILE   A C   1 
ATOM   615  O  O   . ILE   A 1  79  ? -7.709  -15.312 -7.849  1    28.083  ? 115  ILE   A O   1 
ATOM   616  C  CB  . ILE   A 1  79  ? -10.85  -16.388 -7.15   1    28.577  ? 115  ILE   A CB  1 
ATOM   617  C  CG1 . ILE   A 1  79  ? -12.264 -16.027 -7.633  1    27.266  ? 115  ILE   A CG1 1 
ATOM   618  C  CG2 . ILE   A 1  79  ? -10.404 -15.469 -6.009  1    26.819  ? 115  ILE   A CG2 1 
ATOM   619  C  CD1 . ILE   A 1  79  ? -13.363 -16.314 -6.613  1    27.445  ? 115  ILE   A CD1 1 
ATOM   620  N  N   . ILE   A 1  80  ? -7.97   -17.51  -7.461  1    27.135  ? 116  ILE   A N   1 
ATOM   621  C  CA  . ILE   A 1  80  ? -6.659  -17.66  -6.868  1    25.807  ? 116  ILE   A CA  1 
ATOM   622  C  C   . ILE   A 1  80  ? -5.577  -17.276 -7.866  1    24.136  ? 116  ILE   A C   1 
ATOM   623  O  O   . ILE   A 1  80  ? -4.618  -16.596 -7.502  1    23.149  ? 116  ILE   A O   1 
ATOM   624  C  CB  . ILE   A 1  80  ? -6.452  -19.082 -6.314  1    27.858  ? 116  ILE   A CB  1 
ATOM   625  C  CG1 . ILE   A 1  80  ? -7.192  -19.144 -4.959  1    28.564  ? 116  ILE   A CG1 1 
ATOM   626  C  CG2 . ILE   A 1  80  ? -4.959  -19.361 -6.166  1    21.851  ? 116  ILE   A CG2 1 
ATOM   627  C  CD1 . ILE   A 1  80  ? -7.335  -20.5   -4.31   1    28.201  ? 116  ILE   A CD1 1 
ATOM   628  N  N   . LYS   A 1  81  ? -5.744  -17.734 -9.103  1    27.546  ? 117  LYS   A N   1 
ATOM   629  C  CA  . LYS   A 1  81  ? -4.784  -17.37  -10.14  1    32.67   ? 117  LYS   A CA  1 
ATOM   630  C  C   . LYS   A 1  81  ? -4.671  -15.834 -10.284 1    27.765  ? 117  LYS   A C   1 
ATOM   631  O  O   . LYS   A 1  81  ? -3.573  -15.239 -10.384 1    28.144  ? 117  LYS   A O   1 
ATOM   632  C  CB  . LYS   A 1  81  ? -5.118  -18.173 -11.415 1    36.701  ? 117  LYS   A CB  1 
ATOM   633  C  CG  . LYS   A 1  81  ? -4.104  -17.926 -12.534 1    44.551  ? 117  LYS   A CG  1 
ATOM   634  C  CD  . LYS   A 1  81  ? -4.087  -19.079 -13.536 1    68.376  ? 117  LYS   A CD  1 
ATOM   635  C  CE  . LYS   A 1  81  ? -5.431  -19.392 -14.166 1    83.847  ? 117  LYS   A CE  1 
ATOM   636  N  NZ  . LYS   A 1  81  ? -5.504  -20.772 -14.655 1    63.372  ? 117  LYS   A NZ  1 
ATOM   637  N  N   . LYS   A 1  82  ? -5.813  -15.162 -10.268 1    30.071  ? 118  LYS   A N   1 
ATOM   638  C  CA  . LYS   A 1  82  ? -5.817  -13.7   -10.319 1    27.847  ? 118  LYS   A CA  1 
ATOM   639  C  C   . LYS   A 1  82  ? -5.159  -13.05  -9.084  1    31.196  ? 118  LYS   A C   1 
ATOM   640  O  O   . LYS   A 1  82  ? -4.436  -12.054 -9.218  1    30.814  ? 118  LYS   A O   1 
ATOM   641  C  CB  . LYS   A 1  82  ? -7.266  -13.25  -10.52  1    25.486  ? 118  LYS   A CB  1 
ATOM   642  C  CG  . LYS   A 1  82  ? -7.4    -11.724 -10.466 1    32.582  ? 118  LYS   A CG  1 
ATOM   643  C  CD  . LYS   A 1  82  ? -8.554  -11.278 -11.346 1    37.34   ? 118  LYS   A CD  1 
ATOM   644  C  CE  . LYS   A 1  82  ? -8.466  -9.867  -11.812 1    49.163  ? 118  LYS   A CE  1 
ATOM   645  N  NZ  . LYS   A 1  82  ? -9.635  -9.161  -11.263 1    55.684  ? 118  LYS   A NZ  1 
ATOM   646  N  N   . VAL   A 1  83  ? -5.347  -13.596 -7.866  1    27.994  ? 119  VAL   A N   1 
ATOM   647  C  CA  . VAL   A 1  83  ? -4.743  -12.959 -6.702  1    24.089  ? 119  VAL   A CA  1 
ATOM   648  C  C   . VAL   A 1  83  ? -3.227  -13.172 -6.678  1    26.259  ? 119  VAL   A C   1 
ATOM   649  O  O   . VAL   A 1  83  ? -2.496  -12.421 -6.016  1    25.461  ? 119  VAL   A O   1 
ATOM   650  C  CB  . VAL   A 1  83  ? -5.462  -13.484 -5.437  1    27.739  ? 119  VAL   A CB  1 
ATOM   651  C  CG1 . VAL   A 1  83  ? -4.86   -12.949 -4.123  1    26.487  ? 119  VAL   A CG1 1 
ATOM   652  C  CG2 . VAL   A 1  83  ? -6.924  -13.098 -5.49   1    25.177  ? 119  VAL   A CG2 1 
ATOM   653  N  N   . GLN   A 1  84  ? -2.737  -14.212 -7.37   1    23.122  ? 120  GLN   A N   1 
ATOM   654  C  CA  . GLN   A 1  84  ? -1.285  -14.385 -7.467  1    24.732  ? 120  GLN   A CA  1 
ATOM   655  C  C   . GLN   A 1  84  ? -0.596  -13.237 -8.228  1    29.317  ? 120  GLN   A C   1 
ATOM   656  O  O   . GLN   A 1  84  ? 0.645   -13.105 -8.216  1    30.431  ? 120  GLN   A O   1 
ATOM   657  C  CB  . GLN   A 1  84  ? -1.038  -15.699 -8.198  1    25.688  ? 120  GLN   A CB  1 
ATOM   658  C  CG  . GLN   A 1  84  ? -1.457  -16.913 -7.383  1    21.815  ? 120  GLN   A CG  1 
ATOM   659  C  CD  . GLN   A 1  84  ? -1.14   -18.187 -8.128  1    28.569  ? 120  GLN   A CD  1 
ATOM   660  O  OE1 . GLN   A 1  84  ? -0.891  -18.145 -9.328  1    30.326  ? 120  GLN   A OE1 1 
ATOM   661  N  NE2 . GLN   A 1  84  ? -1.187  -19.334 -7.466  1    27.179  ? 120  GLN   A NE2 1 
ATOM   662  N  N   . ASP   A 1  85  ? -1.366  -12.378 -8.893  1    28.186  ? 121  ASP   A N   1 
ATOM   663  C  CA  . ASP   A 1  85  ? -0.75   -11.228 -9.527  1    27.454  ? 121  ASP   A CA  1 
ATOM   664  C  C   . ASP   A 1  85  ? -0.816  -10.049 -8.557  1    26.269  ? 121  ASP   A C   1 
ATOM   665  O  O   . ASP   A 1  85  ? -1.909  -9.565  -8.27   1    26.283  ? 121  ASP   A O   1 
ATOM   666  C  CB  . ASP   A 1  85  ? -1.452  -10.913 -10.845 1    27.38   ? 121  ASP   A CB  1 
ATOM   667  C  CG  . ASP   A 1  85  ? -0.851  -9.771  -11.664 1    23.196  ? 121  ASP   A CG  1 
ATOM   668  O  OD1 . ASP   A 1  85  ? 0.051   -9.059  -11.185 1    27.294  ? 121  ASP   A OD1 1 
ATOM   669  O  OD2 . ASP   A 1  85  ? -1.389  -9.503  -12.759 1    22.633  ? 121  ASP   A OD2 1 
ATOM   670  N  N   . LEU   A 1  86  ? 0.348   -9.58   -8.115  1    25.819  ? 122  LEU   A N   1 
ATOM   671  C  CA  . LEU   A 1  86  ? 0.42    -8.552  -7.075  1    29.567  ? 122  LEU   A CA  1 
ATOM   672  C  C   . LEU   A 1  86  ? 0.394   -7.167  -7.699  1    28.416  ? 122  LEU   A C   1 
ATOM   673  O  O   . LEU   A 1  86  ? 0.331   -6.154  -6.951  1    25.5    ? 122  LEU   A O   1 
ATOM   674  C  CB  . LEU   A 1  86  ? 1.685   -8.728  -6.238  1    28.229  ? 122  LEU   A CB  1 
ATOM   675  C  CG  . LEU   A 1  86  ? 1.646   -9.774  -5.104  1    35.247  ? 122  LEU   A CG  1 
ATOM   676  C  CD1 . LEU   A 1  86  ? 1.027   -11.102 -5.487  1    32.508  ? 122  LEU   A CD1 1 
ATOM   677  C  CD2 . LEU   A 1  86  ? 3.143   -10.029 -4.872  1    36.035  ? 122  LEU   A CD2 1 
ATOM   678  N  N   . GLU   A 1  87  ? 0.427   -7.133  -9.058  1    25.069  ? 123  GLU   A N   1 
ATOM   679  C  CA  . GLU   A 1  87  ? 0.63    -5.854  -9.76   1    23.838  ? 123  GLU   A CA  1 
ATOM   680  C  C   . GLU   A 1  87  ? 1.719   -5.05   -9.057  1    22.039  ? 123  GLU   A C   1 
ATOM   681  O  O   . GLU   A 1  87  ? 2.725   -5.61   -8.708  1    20.069  ? 123  GLU   A O   1 
ATOM   682  C  CB  . GLU   A 1  87  ? -0.654  -5.027  -9.764  1    31.591  ? 123  GLU   A CB  1 
ATOM   683  C  CG  . GLU   A 1  87  ? -1.857  -5.879  -10.16  1    44.349  ? 123  GLU   A CG  1 
ATOM   684  C  CD  . GLU   A 1  87  ? -2.565  -5.528  -11.45  1    55.298  ? 123  GLU   A CD  1 
ATOM   685  O  OE1 . GLU   A 1  87  ? -3.77   -5.287  -11.32  1    56.111  ? 123  GLU   A OE1 1 
ATOM   686  O  OE2 . GLU   A 1  87  ? -1.963  -5.463  -12.545 1    72.036  ? 123  GLU   A OE2 1 
ATOM   687  N  N   . ARG   A 1  88  ? 1.536   -3.746  -8.826  1    21.388  ? 124  ARG   A N   1 
ATOM   688  C  CA  . ARG   A 1  88  ? 2.675   -2.943  -8.424  1    23.022  ? 124  ARG   A CA  1 
ATOM   689  C  C   . ARG   A 1  88  ? 3.123   -3.4    -7.038  1    26.815  ? 124  ARG   A C   1 
ATOM   690  O  O   . ARG   A 1  88  ? 4.198   -3.003  -6.607  1    26.579  ? 124  ARG   A O   1 
ATOM   691  C  CB  . ARG   A 1  88  ? 2.249   -1.472  -8.262  1    25.272  ? 124  ARG   A CB  1 
ATOM   692  C  CG  . ARG   A 1  88  ? 1.157   -1.263  -7.218  1    24.668  ? 124  ARG   A CG  1 
ATOM   693  C  CD  . ARG   A 1  88  ? 0.78    0.214   -7.319  1    30.411  ? 124  ARG   A CD  1 
ATOM   694  N  NE  . ARG   A 1  88  ? -0.227  0.446   -8.37   1    34.053  ? 124  ARG   A NE  1 
ATOM   695  C  CZ  . ARG   A 1  88  ? -0.888  1.595   -8.555  1    43.505  ? 124  ARG   A CZ  1 
ATOM   696  N  NH1 . ARG   A 1  88  ? -0.628  2.639   -7.75   1    35.415  ? 124  ARG   A NH1 1 
ATOM   697  N  NH2 . ARG   A 1  88  ? -1.763  1.733   -9.562  1    38.062  ? 124  ARG   A NH2 1 
ATOM   698  N  N   . ALA   A 1  89  ? 2.223   -4.068  -6.289  1    27.329  ? 125  ALA   A N   1 
ATOM   699  C  CA  . ALA   A 1  89  ? 2.592   -4.45   -4.909  1    32.658  ? 125  ALA   A CA  1 
ATOM   700  C  C   . ALA   A 1  89  ? 3.685   -5.528  -4.899  1    30.732  ? 125  ALA   A C   1 
ATOM   701  O  O   . ALA   A 1  89  ? 4.197   -5.873  -3.853  1    26.387  ? 125  ALA   A O   1 
ATOM   702  C  CB  . ALA   A 1  89  ? 1.371   -4.77   -4      1    26.507  ? 125  ALA   A CB  1 
ATOM   703  N  N   . ALA   A 1  90  ? 4.143   -5.975  -6.081  1    28.227  ? 126  ALA   A N   1 
ATOM   704  C  CA  . ALA   A 1  90  ? 5.278   -6.892  -6.163  1    25.791  ? 126  ALA   A CA  1 
ATOM   705  C  C   . ALA   A 1  90  ? 6.597   -6.145  -6.026  1    26.801  ? 126  ALA   A C   1 
ATOM   706  O  O   . ALA   A 1  90  ? 7.611   -6.791  -5.873  1    29.664  ? 126  ALA   A O   1 
ATOM   707  C  CB  . ALA   A 1  90  ? 5.261   -7.667  -7.503  1    22.533  ? 126  ALA   A CB  1 
ATOM   708  N  N   . LEU   A 1  91  ? 6.606   -4.821  -6.216  1    23.214  ? 127  LEU   A N   1 
ATOM   709  C  CA  . LEU   A 1  91  ? 7.841   -4.056  -6.226  1    22.658  ? 127  LEU   A CA  1 
ATOM   710  C  C   . LEU   A 1  91  ? 8.459   -4.062  -4.814  1    26.807  ? 127  LEU   A C   1 
ATOM   711  O  O   . LEU   A 1  91  ? 7.717   -4.129  -3.857  1    22.964  ? 127  LEU   A O   1 
ATOM   712  C  CB  . LEU   A 1  91  ? 7.658   -2.611  -6.698  1    21.036  ? 127  LEU   A CB  1 
ATOM   713  C  CG  . LEU   A 1  91  ? 7.245   -2.486  -8.17   1    22.068  ? 127  LEU   A CG  1 
ATOM   714  C  CD1 . LEU   A 1  91  ? 6.65    -1.092  -8.388  1    20.762  ? 127  LEU   A CD1 1 
ATOM   715  C  CD2 . LEU   A 1  91  ? 8.451   -2.702  -9.049  1    19.217  ? 127  LEU   A CD2 1 
ATOM   716  N  N   . PRO   A 1  92  ? 9.8     -3.982  -4.635  1    24.805  ? 128  PRO   A N   1 
ATOM   717  C  CA  . PRO   A 1  92  ? 10.371  -3.716  -3.297  1    28.395  ? 128  PRO   A CA  1 
ATOM   718  C  C   . PRO   A 1  92  ? 9.784   -2.395  -2.828  1    30.189  ? 128  PRO   A C   1 
ATOM   719  O  O   . PRO   A 1  92  ? 9.405   -1.581  -3.636  1    27.122  ? 128  PRO   A O   1 
ATOM   720  C  CB  . PRO   A 1  92  ? 11.837  -3.477  -3.684  1    28.342  ? 128  PRO   A CB  1 
ATOM   721  C  CG  . PRO   A 1  92  ? 12.018  -4.378  -4.855  1    28.928  ? 128  PRO   A CG  1 
ATOM   722  C  CD  . PRO   A 1  92  ? 10.808  -4.097  -5.706  1    24.798  ? 128  PRO   A CD  1 
ATOM   723  N  N   . ALA   A 1  93  ? 9.773   -2.132  -1.523  1    31.114  ? 129  ALA   A N   1 
ATOM   724  C  CA  . ALA   A 1  93  ? 9.01    -1.048  -0.939  1    35.703  ? 129  ALA   A CA  1 
ATOM   725  C  C   . ALA   A 1  93  ? 9.472   0.314   -1.467  1    30.459  ? 129  ALA   A C   1 
ATOM   726  O  O   . ALA   A 1  93  ? 8.642   1.206   -1.624  1    28.937  ? 129  ALA   A O   1 
ATOM   727  C  CB  . ALA   A 1  93  ? 9.096   -1.153  0.583   1    35.599  ? 129  ALA   A CB  1 
ATOM   728  N  N   . GLN   A 1  94  ? 10.779  0.476   -1.708  1    30.255  ? 130  GLN   A N   1 
ATOM   729  C  CA  . GLN   A 1  94  ? 11.31   1.757   -2.15   1    37.385  ? 130  GLN   A CA  1 
ATOM   730  C  C   . GLN   A 1  94  ? 10.809  2.098   -3.569  1    34.204  ? 130  GLN   A C   1 
ATOM   731  O  O   . GLN   A 1  94  ? 10.373  3.212   -3.833  1    28.775  ? 130  GLN   A O   1 
ATOM   732  C  CB  . GLN   A 1  94  ? 12.841  1.743   -2.109  1    38.468  ? 130  GLN   A CB  1 
ATOM   733  C  CG  . GLN   A 1  94  ? 13.49   2.853   -2.934  1    57.618  ? 130  GLN   A CG  1 
ATOM   734  C  CD  . GLN   A 1  94  ? 14.576  3.617   -2.202  1    85.434  ? 130  GLN   A CD  1 
ATOM   735  O  OE1 . GLN   A 1  94  ? 15.774  3.396   -2.41   1    91.041  ? 130  GLN   A OE1 1 
ATOM   736  N  NE2 . GLN   A 1  94  ? 14.169  4.518   -1.315  1    94.309  ? 130  GLN   A NE2 1 
ATOM   737  N  N   . GLU   A 1  95  ? 10.909  1.133   -4.48   1    29.023  ? 131  GLU   A N   1 
ATOM   738  C  CA  . GLU   A 1  95  ? 10.365  1.293   -5.817  1    34.787  ? 131  GLU   A CA  1 
ATOM   739  C  C   . GLU   A 1  95  ? 8.835   1.454   -5.767  1    32.363  ? 131  GLU   A C   1 
ATOM   740  O  O   . GLU   A 1  95  ? 8.23    2.132   -6.602  1    33.103  ? 131  GLU   A O   1 
ATOM   741  C  CB  . GLU   A 1  95  ? 10.652  0.007   -6.59   1    36.261  ? 131  GLU   A CB  1 
ATOM   742  C  CG  . GLU   A 1  95  ? 12.043  -0.044  -7.216  1    40.443  ? 131  GLU   A CG  1 
ATOM   743  C  CD  . GLU   A 1  95  ? 13.154  -0.545  -6.31   1    57.567  ? 131  GLU   A CD  1 
ATOM   744  O  OE1 . GLU   A 1  95  ? 13.116  -0.569  -5.047  1    45.983  ? 131  GLU   A OE1 1 
ATOM   745  O  OE2 . GLU   A 1  95  ? 14.101  -0.979  -6.982  1    66.478  ? 131  GLU   A OE2 1 
ATOM   746  N  N   . LEU   A 1  96  ? 8.181   0.75    -4.847  1    26.155  ? 132  LEU   A N   1 
ATOM   747  C  CA  . LEU   A 1  96  ? 6.739   0.873   -4.782  1    25.319  ? 132  LEU   A CA  1 
ATOM   748  C  C   . LEU   A 1  96  ? 6.366   2.3     -4.426  1    30.95   ? 132  LEU   A C   1 
ATOM   749  O  O   . LEU   A 1  96  ? 5.46    2.88    -5.027  1    25.33   ? 132  LEU   A O   1 
ATOM   750  C  CB  . LEU   A 1  96  ? 6.169   -0.103  -3.778  1    23.239  ? 132  LEU   A CB  1 
ATOM   751  C  CG  . LEU   A 1  96  ? 4.703   0.113   -3.397  1    24.587  ? 132  LEU   A CG  1 
ATOM   752  C  CD1 . LEU   A 1  96  ? 3.799   -0.125  -4.623  1    26.162  ? 132  LEU   A CD1 1 
ATOM   753  C  CD2 . LEU   A 1  96  ? 4.396   -0.796  -2.194  1    33.455  ? 132  LEU   A CD2 1 
ATOM   754  N  N   . GLU   A 1  97  ? 7.07    2.875   -3.437  1    27.354  ? 133  GLU   A N   1 
ATOM   755  C  CA  . GLU   A 1  97  ? 6.767   4.245   -3.054  1    27.686  ? 133  GLU   A CA  1 
ATOM   756  C  C   . GLU   A 1  97  ? 7.103   5.187   -4.201  1    27.426  ? 133  GLU   A C   1 
ATOM   757  O  O   . GLU   A 1  97  ? 6.365   6.12    -4.441  1    26.326  ? 133  GLU   A O   1 
ATOM   758  C  CB  . GLU   A 1  97  ? 7.578   4.645   -1.806  1    34.35   ? 133  GLU   A CB  1 
ATOM   759  C  CG  . GLU   A 1  97  ? 7.527   6.122   -1.403  1    42.585  ? 133  GLU   A CG  1 
ATOM   760  C  CD  . GLU   A 1  97  ? 7.966   6.154   0.079   1    64.403  ? 133  GLU   A CD  1 
ATOM   761  O  OE1 . GLU   A 1  97  ? 9.11    5.722   0.339   1    61.588  ? 133  GLU   A OE1 1 
ATOM   762  O  OE2 . GLU   A 1  97  ? 7.185   6.524   1.004   1    59.764  ? 133  GLU   A OE2 1 
ATOM   763  N  N   . GLU   A 1  98  ? 8.216   4.958   -4.895  1    26.445  ? 134  GLU   A N   1 
ATOM   764  C  CA  . GLU   A 1  98  ? 8.56    5.896   -5.947  1    27.707  ? 134  GLU   A CA  1 
ATOM   765  C  C   . GLU   A 1  98  ? 7.511   5.764   -7.054  1    25.485  ? 134  GLU   A C   1 
ATOM   766  O  O   . GLU   A 1  98  ? 7.129   6.765   -7.694  1    28.347  ? 134  GLU   A O   1 
ATOM   767  C  CB  . GLU   A 1  98  ? 9.888   5.393   -6.518  1    26.586  ? 134  GLU   A CB  1 
ATOM   768  C  CG  . GLU   A 1  98  ? 10.479  6.324   -7.579  1    29.211  ? 134  GLU   A CG  1 
ATOM   769  C  CD  . GLU   A 1  98  ? 11.871  5.976   -8.072  1    34.827  ? 134  GLU   A CD  1 
ATOM   770  O  OE1 . GLU   A 1  98  ? 12.324  4.872   -7.688  1    41.141  ? 134  GLU   A OE1 1 
ATOM   771  O  OE2 . GLU   A 1  98  ? 12.426  6.729   -8.891  1    41      ? 134  GLU   A OE2 1 
ATOM   772  N  N   . TYR   A 1  99  ? 7.15    4.504   -7.373  1    23.718  ? 135  TYR   A N   1 
ATOM   773  C  CA  . TYR   A 1  99  ? 6.151   4.279   -8.428  1    23.799  ? 135  TYR   A CA  1 
ATOM   774  C  C   . TYR   A 1  99  ? 4.846   5.041   -8.125  1    22.58   ? 135  TYR   A C   1 
ATOM   775  O  O   . TYR   A 1  99  ? 4.316   5.779   -8.973  1    22.544  ? 135  TYR   A O   1 
ATOM   776  C  CB  . TYR   A 1  99  ? 5.854   2.795   -8.509  1    21.342  ? 135  TYR   A CB  1 
ATOM   777  C  CG  . TYR   A 1  99  ? 4.913   2.529   -9.665  1    24.192  ? 135  TYR   A CG  1 
ATOM   778  C  CD1 . TYR   A 1  99  ? 5.273   2.869   -10.982 1    24.809  ? 135  TYR   A CD1 1 
ATOM   779  C  CD2 . TYR   A 1  99  ? 3.687   1.905   -9.44   1    27      ? 135  TYR   A CD2 1 
ATOM   780  C  CE1 . TYR   A 1  99  ? 4.398   2.608   -12.032 1    28.235  ? 135  TYR   A CE1 1 
ATOM   781  C  CE2 . TYR   A 1  99  ? 2.837   1.59    -10.499 1    29.408  ? 135  TYR   A CE2 1 
ATOM   782  C  CZ  . TYR   A 1  99  ? 3.173   1.997   -11.787 1    28.013  ? 135  TYR   A CZ  1 
ATOM   783  O  OH  . TYR   A 1  99  ? 2.304   1.741   -12.794 1    24.956  ? 135  TYR   A OH  1 
ATOM   784  N  N   . ASN   A 1  100 ? 4.358   4.95    -6.886  1    20.944  ? 136  ASN   A N   1 
ATOM   785  C  CA  . ASN   A 1  100 ? 3.07    5.536   -6.553  1    26.295  ? 136  ASN   A CA  1 
ATOM   786  C  C   . ASN   A 1  100 ? 3.169   7.049   -6.632  1    26.829  ? 136  ASN   A C   1 
ATOM   787  O  O   . ASN   A 1  100 ? 2.206   7.714   -7.015  1    27.027  ? 136  ASN   A O   1 
ATOM   788  C  CB  . ASN   A 1  100 ? 2.572   5.064   -5.185  1    30.428  ? 136  ASN   A CB  1 
ATOM   789  C  CG  . ASN   A 1  100 ? 2.087   3.632   -5.233  1    30.575  ? 136  ASN   A CG  1 
ATOM   790  O  OD1 . ASN   A 1  100 ? 1.57    3.165   -6.255  1    30.239  ? 136  ASN   A OD1 1 
ATOM   791  N  ND2 . ASN   A 1  100 ? 2.3     2.896   -4.165  1    31.437  ? 136  ASN   A ND2 1 
ATOM   792  N  N   . LYS   A 1  101 ? 4.378   7.551   -6.337  1    27.393  ? 137  LYS   A N   1 
ATOM   793  C  CA  . LYS   A 1  101 ? 4.554   8.984   -6.335  1    26.48   ? 137  LYS   A CA  1 
ATOM   794  C  C   . LYS   A 1  101 ? 4.604   9.503   -7.772  1    25.819  ? 137  LYS   A C   1 
ATOM   795  O  O   . LYS   A 1  101 ? 4.019   10.551  -8.065  1    21.544  ? 137  LYS   A O   1 
ATOM   796  C  CB  . LYS   A 1  101 ? 5.694   9.422   -5.394  1    27.472  ? 137  LYS   A CB  1 
ATOM   797  C  CG  . LYS   A 1  101 ? 5.584   10.907  -5.26   1    38.706  ? 137  LYS   A CG  1 
ATOM   798  C  CD  . LYS   A 1  101 ? 6.592   11.902  -4.707  1    59.684  ? 137  LYS   A CD  1 
ATOM   799  C  CE  . LYS   A 1  101 ? 5.874   13.232  -4.773  1    56.452  ? 137  LYS   A CE  1 
ATOM   800  N  NZ  . LYS   A 1  101 ? 6.814   14.302  -4.456  1    85.445  ? 137  LYS   A NZ  1 
ATOM   801  N  N   . ILE   A 1  102 ? 5.263   8.726   -8.647  1    23.722  ? 138  ILE   A N   1 
ATOM   802  C  CA  . ILE   A 1  102 ? 5.302   9.014   -10.073 1    24.604  ? 138  ILE   A CA  1 
ATOM   803  C  C   . ILE   A 1  102 ? 3.879   9.088   -10.662 1    20.729  ? 138  ILE   A C   1 
ATOM   804  O  O   . ILE   A 1  102 ? 3.552   10.029  -11.346 1    22.623  ? 138  ILE   A O   1 
ATOM   805  C  CB  . ILE   A 1  102 ? 6.203   8.001   -10.791 1    23.282  ? 138  ILE   A CB  1 
ATOM   806  C  CG1 . ILE   A 1  102 ? 7.69    8.38    -10.6   1    31.958  ? 138  ILE   A CG1 1 
ATOM   807  C  CG2 . ILE   A 1  102 ? 5.93    7.984   -12.307 1    25.424  ? 138  ILE   A CG2 1 
ATOM   808  C  CD1 . ILE   A 1  102 ? 8.626   7.275   -11.077 1    33.072  ? 138  ILE   A CD1 1 
ATOM   809  N  N   . LEU   A 1  103 ? 3.046   8.088   -10.4   1    22.348  ? 139  LEU   A N   1 
ATOM   810  C  CA  . LEU   A 1  103 ? 1.7     8.075   -10.891 1    22.401  ? 139  LEU   A CA  1 
ATOM   811  C  C   . LEU   A 1  103 ? 0.96    9.316   -10.426 1    27.588  ? 139  LEU   A C   1 
ATOM   812  O  O   . LEU   A 1  103 ? 0.196   9.965   -11.186 1    21.85   ? 139  LEU   A O   1 
ATOM   813  C  CB  . LEU   A 1  103 ? 0.996   6.782   -10.484 1    24.141  ? 139  LEU   A CB  1 
ATOM   814  C  CG  . LEU   A 1  103 ? 1.534   5.48    -11.086 1    25.098  ? 139  LEU   A CG  1 
ATOM   815  C  CD1 . LEU   A 1  103 ? 0.622   4.432   -10.511 1    28.252  ? 139  LEU   A CD1 1 
ATOM   816  C  CD2 . LEU   A 1  103 ? 1.386   5.381   -12.636 1    24.582  ? 139  LEU   A CD2 1 
ATOM   817  N  N   . LEU   A 1  104 ? 1.173   9.634   -9.134  1    25.305  ? 140  LEU   A N   1 
ATOM   818  C  CA  . LEU   A 1  104 ? 0.377   10.705  -8.586  1    22.55   ? 140  LEU   A CA  1 
ATOM   819  C  C   . LEU   A 1  104 ? 0.809   11.991  -9.263  1    23.251  ? 140  LEU   A C   1 
ATOM   820  O  O   . LEU   A 1  104 ? -0.044  12.791  -9.594  1    23.316  ? 140  LEU   A O   1 
ATOM   821  C  CB  . LEU   A 1  104 ? 0.604   10.845  -7.075  1    23.811  ? 140  LEU   A CB  1 
ATOM   822  C  CG  . LEU   A 1  104 ? -0.081  12.09   -6.505  1    30.251  ? 140  LEU   A CG  1 
ATOM   823  C  CD1 . LEU   A 1  104 ? -1.392  11.631  -5.972  1    31.981  ? 140  LEU   A CD1 1 
ATOM   824  C  CD2 . LEU   A 1  104 ? 0.859   12.66   -5.406  1    38.549  ? 140  LEU   A CD2 1 
ATOM   825  N  N   . ASP   A 1  105 ? 2.124   12.147  -9.474  1    22.666  ? 141  ASP   A N   1 
ATOM   826  C  CA  . ASP   A 1  105 ? 2.713   13.36   -10.02  1    23.334  ? 141  ASP   A CA  1 
ATOM   827  C  C   . ASP   A 1  105 ? 2.3     13.524  -11.478 1    22.737  ? 141  ASP   A C   1 
ATOM   828  O  O   . ASP   A 1  105 ? 1.923   14.636  -11.911 1    19.838  ? 141  ASP   A O   1 
ATOM   829  C  CB  . ASP   A 1  105 ? 4.223   13.35   -9.905  1    26.479  ? 141  ASP   A CB  1 
ATOM   830  C  CG  . ASP   A 1  105 ? 4.706   13.581  -8.474  1    32.487  ? 141  ASP   A CG  1 
ATOM   831  O  OD1 . ASP   A 1  105 ? 3.871   13.95   -7.598  1    27.185  ? 141  ASP   A OD1 1 
ATOM   832  O  OD2 . ASP   A 1  105 ? 5.888   13.31   -8.252  1    31.285  ? 141  ASP   A OD2 1 
ATOM   833  N  N   . MET   A 1  106 ? 2.22    12.388  -12.16  1    20.579  ? 142  MET   A N   1 
ATOM   834  C  CA  . MET   A 1  106 ? 1.757   12.474  -13.55  1    19.705  ? 142  MET   A CA  1 
ATOM   835  C  C   . MET   A 1  106 ? 0.294   12.924  -13.662 1    20.75   ? 142  MET   A C   1 
ATOM   836  O  O   . MET   A 1  106 ? -0.025  13.787  -14.469 1    20.197  ? 142  MET   A O   1 
ATOM   837  C  CB  . MET   A 1  106 ? 1.971   11.175  -14.329 1    18.64   ? 142  MET   A CB  1 
ATOM   838  C  CG  . MET   A 1  106 ? 3.451   10.799  -14.585 1    18.189  ? 142  MET   A CG  1 
ATOM   839  S  SD  . MET   A 1  106 ? 3.675   9.587   -15.9   1    21.081  ? 142  MET   A SD  1 
ATOM   840  C  CE  . MET   A 1  106 ? 2.906   8.201   -15.061 1    20.362  ? 142  MET   A CE  1 
ATOM   841  N  N   . GLU   A 1  107 ? -0.605  12.31   -12.888 1    21.825  ? 143  GLU   A N   1 
ATOM   842  C  CA  . GLU   A 1  107 ? -2.028  12.625  -12.939 1    27.883  ? 143  GLU   A CA  1 
ATOM   843  C  C   . GLU   A 1  107 ? -2.25   14.091  -12.588 1    27.307  ? 143  GLU   A C   1 
ATOM   844  O  O   . GLU   A 1  107 ? -3.002  14.793  -13.267 1    27.822  ? 143  GLU   A O   1 
ATOM   845  C  CB  . GLU   A 1  107 ? -2.806  11.879  -11.852 1    34.85   ? 143  GLU   A CB  1 
ATOM   846  C  CG  . GLU   A 1  107 ? -2.882  10.372  -12.069 1    66.664  ? 143  GLU   A CG  1 
ATOM   847  C  CD  . GLU   A 1  107 ? -3.783  9.528   -11.169 1    76.867  ? 143  GLU   A CD  1 
ATOM   848  O  OE1 . GLU   A 1  107 ? -4.428  10.066  -10.237 1    71.518  ? 143  GLU   A OE1 1 
ATOM   849  O  OE2 . GLU   A 1  107 ? -3.851  8.303   -11.433 1    85.115  ? 143  GLU   A OE2 1 
ATOM   850  N  N   . THR   A 1  108 ? -1.638  14.492  -11.456 1    20.231  ? 144  THR   A N   1 
ATOM   851  C  CA  . THR   A 1  108 ? -1.736  15.86   -11.014 1    23.817  ? 144  THR   A CA  1 
ATOM   852  C  C   . THR   A 1  108 ? -1.244  16.799  -12.088 1    17.536  ? 144  THR   A C   1 
ATOM   853  O  O   . THR   A 1  108 ? -1.948  17.769  -12.359 1    26.684  ? 144  THR   A O   1 
ATOM   854  C  CB  . THR   A 1  108 ? -0.95   16.078  -9.703  1    26.681  ? 144  THR   A CB  1 
ATOM   855  O  OG1 . THR   A 1  108 ? -1.614  15.282  -8.721  1    29.533  ? 144  THR   A OG1 1 
ATOM   856  C  CG2 . THR   A 1  108 ? -1.091  17.491  -9.198  1    25.112  ? 144  THR   A CG2 1 
ATOM   857  N  N   . THR   A 1  109 ? -0.06   16.574  -12.662 1    19.986  ? 145  THR   A N   1 
ATOM   858  C  CA  . THR   A 1  109 ? 0.447   17.457  -13.723 1    22.706  ? 145  THR   A CA  1 
ATOM   859  C  C   . THR   A 1  109 ? -0.594  17.611  -14.85  1    25.134  ? 145  THR   A C   1 
ATOM   860  O  O   . THR   A 1  109 ? -0.878  18.711  -15.337 1    20.282  ? 145  THR   A O   1 
ATOM   861  C  CB  . THR   A 1  109 ? 1.77    16.925  -14.305 1    26.572  ? 145  THR   A CB  1 
ATOM   862  O  OG1 . THR   A 1  109 ? 2.67    16.85   -13.204 1    23.932  ? 145  THR   A OG1 1 
ATOM   863  C  CG2 . THR   A 1  109 ? 2.335   17.757  -15.461 1    20.4    ? 145  THR   A CG2 1 
ATOM   864  N  N   . TYR   A 1  110 ? -1.091  16.482  -15.334 1    20.6    ? 146  TYR   A N   1 
ATOM   865  C  CA  . TYR   A 1  110 ? -2.069  16.52   -16.429 1    22.337  ? 146  TYR   A CA  1 
ATOM   866  C  C   . TYR   A 1  110 ? -3.287  17.343  -16.012 1    21.494  ? 146  TYR   A C   1 
ATOM   867  O  O   . TYR   A 1  110 ? -3.787  18.156  -16.799 1    22.817  ? 146  TYR   A O   1 
ATOM   868  C  CB  . TYR   A 1  110 ? -2.405  15.082  -16.866 1    19.099  ? 146  TYR   A CB  1 
ATOM   869  C  CG  . TYR   A 1  110 ? -3.445  15.052  -17.995 1    21.914  ? 146  TYR   A CG  1 
ATOM   870  C  CD1 . TYR   A 1  110 ? -4.819  15.152  -17.716 1    20.826  ? 146  TYR   A CD1 1 
ATOM   871  C  CD2 . TYR   A 1  110 ? -3.038  14.965  -19.338 1    20.672  ? 146  TYR   A CD2 1 
ATOM   872  C  CE1 . TYR   A 1  110 ? -5.762  15.082  -18.749 1    19.538  ? 146  TYR   A CE1 1 
ATOM   873  C  CE2 . TYR   A 1  110 ? -3.966  14.835  -20.371 1    17.228  ? 146  TYR   A CE2 1 
ATOM   874  C  CZ  . TYR   A 1  110 ? -5.315  14.943  -20.074 1    19.211  ? 146  TYR   A CZ  1 
ATOM   875  O  OH  . TYR   A 1  110 ? -6.235  14.889  -21.11  1    19.56   ? 146  TYR   A OH  1 
ATOM   876  N  N   . SER   A 1  111 ? -3.809  17.066  -14.81  1    18.234  ? 147  SER   A N   1 
ATOM   877  C  CA  . SER   A 1  111 ? -5.113  17.573  -14.421 1    22.447  ? 147  SER   A CA  1 
ATOM   878  C  C   . SER   A 1  111 ? -5.062  19.051  -14.036 1    24.7    ? 147  SER   A C   1 
ATOM   879  O  O   . SER   A 1  111 ? -6.123  19.67   -14.016 1    25.774  ? 147  SER   A O   1 
ATOM   880  C  CB  . SER   A 1  111 ? -5.81   16.75   -13.332 1    25.574  ? 147  SER   A CB  1 
ATOM   881  O  OG  . SER   A 1  111 ? -6.261  15.519  -13.889 1    26.782  ? 147  SER   A OG  1 
ATOM   882  N  N   . VAL   A 1  112 ? -3.844  19.591  -13.812 1    20.621  ? 148  VAL   A N   1 
ATOM   883  C  CA  . VAL   A 1  112 ? -3.768  21.009  -13.429 1    26.162  ? 148  VAL   A CA  1 
ATOM   884  C  C   . VAL   A 1  112 ? -3.111  21.873  -14.5   1    23.11   ? 148  VAL   A C   1 
ATOM   885  O  O   . VAL   A 1  112 ? -3.024  23.089  -14.306 1    22.389  ? 148  VAL   A O   1 
ATOM   886  C  CB  . VAL   A 1  112 ? -3.087  21.312  -12.071 1    25.258  ? 148  VAL   A CB  1 
ATOM   887  C  CG1 . VAL   A 1  112 ? -3.796  20.53   -10.975 1    25.604  ? 148  VAL   A CG1 1 
ATOM   888  C  CG2 . VAL   A 1  112 ? -1.597  21.011  -12.044 1    23.891  ? 148  VAL   A CG2 1 
ATOM   889  N  N   . ALA   A 1  113 ? -2.679  21.286  -15.622 1    23.434  ? 149  ALA   A N   1 
ATOM   890  C  CA  . ALA   A 1  113 ? -2.01   22.054  -16.666 1    24.566  ? 149  ALA   A CA  1 
ATOM   891  C  C   . ALA   A 1  113 ? -2.958  23.146  -17.199 1    23.997  ? 149  ALA   A C   1 
ATOM   892  O  O   . ALA   A 1  113 ? -4.147  22.902  -17.435 1    26.051  ? 149  ALA   A O   1 
ATOM   893  C  CB  . ALA   A 1  113 ? -1.586  21.103  -17.787 1    23.548  ? 149  ALA   A CB  1 
ATOM   894  N  N   . THR   A 1  114 ? -2.393  24.324  -17.49  1    25.985  ? 150  THR   A N   1 
ATOM   895  C  CA  . THR   A 1  114 ? -3.153  25.385  -18.135 1    28.678  ? 150  THR   A CA  1 
ATOM   896  C  C   . THR   A 1  114 ? -2.354  25.976  -19.28  1    24.109  ? 150  THR   A C   1 
ATOM   897  O  O   . THR   A 1  114 ? -1.134  25.873  -19.323 1    27.915  ? 150  THR   A O   1 
ATOM   898  C  CB  . THR   A 1  114 ? -3.767  26.433  -17.178 1    33.179  ? 150  THR   A CB  1 
ATOM   899  O  OG1 . THR   A 1  114 ? -2.617  27.114  -16.728 1    34.507  ? 150  THR   A OG1 1 
ATOM   900  C  CG2 . THR   A 1  114 ? -4.535  25.854  -15.991 1    30.267  ? 150  THR   A CG2 1 
ATOM   901  N  N   . VAL   A 1  115 ? -3.072  26.612  -20.225 1    26.77   ? 151  VAL   A N   1 
ATOM   902  C  CA  . VAL   A 1  115 ? -2.386  27.27   -21.327 1    26.28   ? 151  VAL   A CA  1 
ATOM   903  C  C   . VAL   A 1  115 ? -2.764  28.761  -21.326 1    24.922  ? 151  VAL   A C   1 
ATOM   904  O  O   . VAL   A 1  115 ? -3.934  29.073  -21.314 1    28.279  ? 151  VAL   A O   1 
ATOM   905  C  CB  . VAL   A 1  115 ? -2.694  26.591  -22.681 1    21.385  ? 151  VAL   A CB  1 
ATOM   906  C  CG1 . VAL   A 1  115 ? -1.9    27.252  -23.806 1    23.889  ? 151  VAL   A CG1 1 
ATOM   907  C  CG2 . VAL   A 1  115 ? -2.424  25.063  -22.692 1    20.705  ? 151  VAL   A CG2 1 
ATOM   908  N  N   . CYS   A 1  116 ? -1.789  29.66   -21.307 1    28.242  ? 152  CYS   A N   1 
ATOM   909  C  CA  . CYS   A 1  116 ? -2.021  31.064  -20.969 1    35.69   ? 152  CYS   A CA  1 
ATOM   910  C  C   . CYS   A 1  116 ? -1.602  31.935  -22.15  1    37.418  ? 152  CYS   A C   1 
ATOM   911  O  O   . CYS   A 1  116 ? -0.572  31.681  -22.716 1    33.897  ? 152  CYS   A O   1 
ATOM   912  C  CB  . CYS   A 1  116 ? -1.06   31.506  -19.873 1    29.994  ? 152  CYS   A CB  1 
ATOM   913  S  SG  . CYS   A 1  116 ? -1.317  30.524  -18.37  1    42.383  ? 152  CYS   A SG  1 
ATOM   914  N  N   . HIS   A 1  117 ? -2.397  32.947  -22.505 1    46.191  ? 153  HIS   A N   1 
ATOM   915  C  CA  . HIS   A 1  117 ? -1.973  34.072  -23.327 1    42.055  ? 153  HIS   A CA  1 
ATOM   916  C  C   . HIS   A 1  117 ? -1      34.914  -22.491 1    50.856  ? 153  HIS   A C   1 
ATOM   917  O  O   . HIS   A 1  117 ? -1.038  34.878  -21.258 1    40.258  ? 153  HIS   A O   1 
ATOM   918  C  CB  . HIS   A 1  117 ? -3.244  34.831  -23.707 1    45.558  ? 153  HIS   A CB  1 
ATOM   919  C  CG  . HIS   A 1  117 ? -4.123  34.025  -24.616 1    49.551  ? 153  HIS   A CG  1 
ATOM   920  N  ND1 . HIS   A 1  117 ? -5.369  33.55   -24.257 1    54.488  ? 153  HIS   A ND1 1 
ATOM   921  C  CD2 . HIS   A 1  117 ? -3.94   33.658  -25.9   1    46.828  ? 153  HIS   A CD2 1 
ATOM   922  C  CE1 . HIS   A 1  117 ? -5.908  32.891  -25.288 1    51.378  ? 153  HIS   A CE1 1 
ATOM   923  N  NE2 . HIS   A 1  117 ? -5.053  32.94   -26.287 1    48.528  ? 153  HIS   A NE2 1 
ATOM   924  N  N   . PRO   A 1  118 ? -0.052  35.659  -23.093 1    62.173  ? 154  PRO   A N   1 
ATOM   925  C  CA  . PRO   A 1  118 ? 0.971   36.359  -22.293 1    60.636  ? 154  PRO   A CA  1 
ATOM   926  C  C   . PRO   A 1  118 ? 0.601   37.447  -21.256 1    56.576  ? 154  PRO   A C   1 
ATOM   927  O  O   . PRO   A 1  118 ? -0.471  38.04   -21.469 1    69.855  ? 154  PRO   A O   1 
ATOM   928  C  CB  . PRO   A 1  118 ? 1.877   36.88   -23.413 1    60.728  ? 154  PRO   A CB  1 
ATOM   929  C  CG  . PRO   A 1  118 ? 1.656   35.869  -24.528 1    60.438  ? 154  PRO   A CG  1 
ATOM   930  C  CD  . PRO   A 1  118 ? 0.142   35.768  -24.552 1    62.384  ? 154  PRO   A CD  1 
ATOM   931  N  N   . GLY   A 1  120 ? -2.106  37.896  -20.353 1    43.069  ? 156  GLY   A N   1 
ATOM   932  C  CA  . GLY   A 1  120 ? -3.373  37.268  -20.808 1    47.509  ? 156  GLY   A CA  1 
ATOM   933  C  C   . GLY   A 1  120 ? -3.968  36.238  -19.823 1    44.423  ? 156  GLY   A C   1 
ATOM   934  O  O   . GLY   A 1  120 ? -3.402  35.932  -18.774 1    48.225  ? 156  GLY   A O   1 
ATOM   935  N  N   . SER   A 1  121 ? -5.127  35.653  -20.158 1    42.65   ? 157  SER   A N   1 
ATOM   936  C  CA  . SER   A 1  121 ? -5.686  34.669  -19.234 1    52.867  ? 157  SER   A CA  1 
ATOM   937  C  C   . SER   A 1  121 ? -5.38   33.232  -19.675 1    42.799  ? 157  SER   A C   1 
ATOM   938  O  O   . SER   A 1  121 ? -4.795  32.998  -20.752 1    35.608  ? 157  SER   A O   1 
ATOM   939  C  CB  . SER   A 1  121 ? -7.133  34.872  -18.991 1    60.735  ? 157  SER   A CB  1 
ATOM   940  O  OG  . SER   A 1  121 ? -7.758  34.7    -20.251 1    56.284  ? 157  SER   A OG  1 
ATOM   941  N  N   . CYS   A 1  122 ? -5.662  32.311  -18.741 1    33.496  ? 158  CYS   A N   1 
ATOM   942  C  CA  . CYS   A 1  122 ? -5.121  30.965  -18.755 1    34.303  ? 158  CYS   A CA  1 
ATOM   943  C  C   . CYS   A 1  122 ? -6.27   30.015  -18.996 1    33.1    ? 158  CYS   A C   1 
ATOM   944  O  O   . CYS   A 1  122 ? -7.339  30.219  -18.437 1    38.421  ? 158  CYS   A O   1 
ATOM   945  C  CB  . CYS   A 1  122 ? -4.378  30.656  -17.463 1    43.874  ? 158  CYS   A CB  1 
ATOM   946  S  SG  . CYS   A 1  122 ? -2.778  31.518  -17.34  1    46.603  ? 158  CYS   A SG  1 
ATOM   947  N  N   . LEU   A 1  123 ? -6.104  29.07   -19.91  1    23.841  ? 159  LEU   A N   1 
ATOM   948  C  CA  . LEU   A 1  123 ? -7.245  28.223  -20.244 1    22.487  ? 159  LEU   A CA  1 
ATOM   949  C  C   . LEU   A 1  123 ? -6.961  26.822  -19.696 1    21.566  ? 159  LEU   A C   1 
ATOM   950  O  O   . LEU   A 1  123 ? -5.817  26.349  -19.765 1    20.185  ? 159  LEU   A O   1 
ATOM   951  C  CB  . LEU   A 1  123 ? -7.336  28.168  -21.784 1    26.664  ? 159  LEU   A CB  1 
ATOM   952  C  CG  . LEU   A 1  123 ? -8.085  29.272  -22.551 1    32.345  ? 159  LEU   A CG  1 
ATOM   953  C  CD1 . LEU   A 1  123 ? -7.312  30.549  -22.621 1    35.584  ? 159  LEU   A CD1 1 
ATOM   954  C  CD2 . LEU   A 1  123 ? -8.48   28.839  -23.998 1    31.225  ? 159  LEU   A CD2 1 
ATOM   955  N  N   . GLN   A 1  124 ? -7.998  26.166  -19.163 1    24.635  ? 160  GLN   A N   1 
ATOM   956  C  CA  . GLN   A 1  124 ? -7.887  24.783  -18.698 1    29.486  ? 160  GLN   A CA  1 
ATOM   957  C  C   . GLN   A 1  124 ? -8.39   23.86   -19.804 1    25.193  ? 160  GLN   A C   1 
ATOM   958  O  O   . GLN   A 1  124 ? -9.106  24.331  -20.698 1    24.774  ? 160  GLN   A O   1 
ATOM   959  C  CB  . GLN   A 1  124 ? -8.758  24.641  -17.452 1    28.816  ? 160  GLN   A CB  1 
ATOM   960  C  CG  . GLN   A 1  124 ? -8.179  25.445  -16.285 1    31.815  ? 160  GLN   A CG  1 
ATOM   961  C  CD  . GLN   A 1  124 ? -8.847  25.122  -14.969 1    38.331  ? 160  GLN   A CD  1 
ATOM   962  O  OE1 . GLN   A 1  124 ? -10.071 25.108  -14.848 1    35.871  ? 160  GLN   A OE1 1 
ATOM   963  N  NE2 . GLN   A 1  124 ? -8.03   24.834  -13.971 1    56.081  ? 160  GLN   A NE2 1 
ATOM   964  N  N   . LEU   A 1  125 ? -8.036  22.569  -19.743 1    25.011  ? 161  LEU   A N   1 
ATOM   965  C  CA  . LEU   A 1  125 ? -8.508  21.648  -20.788 1    22.41   ? 161  LEU   A CA  1 
ATOM   966  C  C   . LEU   A 1  125 ? -10.039 21.572  -20.834 1    23.504  ? 161  LEU   A C   1 
ATOM   967  O  O   . LEU   A 1  125 ? -10.635 21.849  -21.885 1    23.675  ? 161  LEU   A O   1 
ATOM   968  C  CB  . LEU   A 1  125 ? -7.784  20.295  -20.728 1    22.514  ? 161  LEU   A CB  1 
ATOM   969  C  CG  . LEU   A 1  125 ? -8.255  19.254  -21.755 1    20.654  ? 161  LEU   A CG  1 
ATOM   970  C  CD1 . LEU   A 1  125 ? -7.727  19.553  -23.119 1    18.504  ? 161  LEU   A CD1 1 
ATOM   971  C  CD2 . LEU   A 1  125 ? -7.877  17.832  -21.326 1    20.562  ? 161  LEU   A CD2 1 
ATOM   972  N  N   . GLU   A 1  126 ? -10.712 21.378  -19.686 1    23.653  ? 162  GLU   A N   1 
ATOM   973  C  CA  . GLU   A 1  126 ? -12.166 21.446  -19.623 1    28.005  ? 162  GLU   A CA  1 
ATOM   974  C  C   . GLU   A 1  126 ? -12.601 22.662  -18.823 1    27.159  ? 162  GLU   A C   1 
ATOM   975  O  O   . GLU   A 1  126 ? -12.231 22.785  -17.645 1    29.437  ? 162  GLU   A O   1 
ATOM   976  C  CB  . GLU   A 1  126 ? -12.628 20.201  -18.873 1    28.495  ? 162  GLU   A CB  1 
ATOM   977  C  CG  . GLU   A 1  126 ? -12.122 18.96   -19.597 1    38.317  ? 162  GLU   A CG  1 
ATOM   978  C  CD  . GLU   A 1  126 ? -12.965 17.747  -19.273 1    50.482  ? 162  GLU   A CD  1 
ATOM   979  O  OE1 . GLU   A 1  126 ? -14.111 18.085  -18.915 1    70.16   ? 162  GLU   A OE1 1 
ATOM   980  O  OE2 . GLU   A 1  126 ? -12.579 16.551  -19.345 1    38.246  ? 162  GLU   A OE2 1 
ATOM   981  N  N   . PRO   A 1  127 ? -13.479 23.545  -19.348 1    29.233  ? 163  PRO   A N   1 
ATOM   982  C  CA  . PRO   A 1  127 ? -14.058 23.385  -20.685 1    26.142  ? 163  PRO   A CA  1 
ATOM   983  C  C   . PRO   A 1  127 ? -13.346 24.186  -21.779 1    24.4    ? 163  PRO   A C   1 
ATOM   984  O  O   . PRO   A 1  127 ? -13.699 24.021  -22.949 1    26.398  ? 163  PRO   A O   1 
ATOM   985  C  CB  . PRO   A 1  127 ? -15.469 23.896  -20.379 1    24.628  ? 163  PRO   A CB  1 
ATOM   986  C  CG  . PRO   A 1  127 ? -15.213 25.113  -19.472 1    28.899  ? 163  PRO   A CG  1 
ATOM   987  C  CD  . PRO   A 1  127 ? -14.024 24.71   -18.597 1    27.233  ? 163  PRO   A CD  1 
ATOM   988  N  N   . ASP   A 1  128 ? -12.337 25.018  -21.423 1    24.527  ? 164  ASP   A N   1 
ATOM   989  C  CA  . ASP   A 1  128 ? -11.891 26.119  -22.284 1    23.562  ? 164  ASP   A CA  1 
ATOM   990  C  C   . ASP   A 1  128 ? -11.24  25.579  -23.557 1    21.21   ? 164  ASP   A C   1 
ATOM   991  O  O   . ASP   A 1  128 ? -11.69  25.906  -24.667 1    23.951  ? 164  ASP   A O   1 
ATOM   992  C  CB  . ASP   A 1  128 ? -10.942 27.061  -21.557 1    20.603  ? 164  ASP   A CB  1 
ATOM   993  C  CG  . ASP   A 1  128 ? -11.479 27.436  -20.179 1    28.095  ? 164  ASP   A CG  1 
ATOM   994  O  OD1 . ASP   A 1  128 ? -12.661 27.755  -20.104 1    29.068  ? 164  ASP   A OD1 1 
ATOM   995  O  OD2 . ASP   A 1  128 ? -10.743 27.275  -19.201 1    31.585  ? 164  ASP   A OD2 1 
ATOM   996  N  N   . LEU   A 1  129 ? -10.179 24.775  -23.408 1    20.223  ? 165  LEU   A N   1 
ATOM   997  C  CA  . LEU   A 1  129 ? -9.469  24.3    -24.604 1    21.288  ? 165  LEU   A CA  1 
ATOM   998  C  C   . LEU   A 1  129 ? -10.321 23.341  -25.425 1    20.301  ? 165  LEU   A C   1 
ATOM   999  O  O   . LEU   A 1  129 ? -10.231 23.351  -26.655 1    21.074  ? 165  LEU   A O   1 
ATOM   1000 C  CB  . LEU   A 1  129 ? -8.133  23.667  -24.248 1    19.252  ? 165  LEU   A CB  1 
ATOM   1001 C  CG  . LEU   A 1  129 ? -7.156  24.661  -23.6   1    20.778  ? 165  LEU   A CG  1 
ATOM   1002 C  CD1 . LEU   A 1  129 ? -5.979  23.893  -23.121 1    20.999  ? 165  LEU   A CD1 1 
ATOM   1003 C  CD2 . LEU   A 1  129 ? -6.7    25.774  -24.546 1    21.303  ? 165  LEU   A CD2 1 
ATOM   1004 N  N   . THR   A 1  130 ? -11.071 22.486  -24.741 1    19.867  ? 166  THR   A N   1 
ATOM   1005 C  CA  . THR   A 1  130 ? -12.052 21.623  -25.426 1    21.301  ? 166  THR   A CA  1 
ATOM   1006 C  C   . THR   A 1  130 ? -12.971 22.458  -26.318 1    21.094  ? 166  THR   A C   1 
ATOM   1007 O  O   . THR   A 1  130 ? -13.221 22.137  -27.498 1    19.206  ? 166  THR   A O   1 
ATOM   1008 C  CB  . THR   A 1  130 ? -12.871 20.847  -24.371 1    23.088  ? 166  THR   A CB  1 
ATOM   1009 O  OG1 . THR   A 1  130 ? -11.832 20.04   -23.783 1    23.544  ? 166  THR   A OG1 1 
ATOM   1010 C  CG2 . THR   A 1  130 ? -13.919 19.946  -25.029 1    23.614  ? 166  THR   A CG2 1 
ATOM   1011 N  N   A ASN   A 1  131 ? -13.483 23.551  -25.761 0.5  19.074  ? 167  ASN   A N   1 
ATOM   1012 N  N   B ASN   A 1  131 ? -13.478 23.544  -25.736 0.5  19.256  ? 167  ASN   A N   1 
ATOM   1013 C  CA  A ASN   A 1  131 ? -14.415 24.382  -26.507 0.5  19.558  ? 167  ASN   A CA  1 
ATOM   1014 C  CA  B ASN   A 1  131 ? -14.39  24.443  -26.425 0.5  20.025  ? 167  ASN   A CA  1 
ATOM   1015 C  C   A ASN   A 1  131 ? -13.684 25.086  -27.662 0.5  19.795  ? 167  ASN   A C   1 
ATOM   1016 C  C   B ASN   A 1  131 ? -13.684 25.083  -27.63  0.5  20.111  ? 167  ASN   A C   1 
ATOM   1017 O  O   A ASN   A 1  131 ? -14.244 25.177  -28.754 0.5  21.737  ? 167  ASN   A O   1 
ATOM   1018 O  O   B ASN   A 1  131 ? -14.261 25.133  -28.717 0.5  22.495  ? 167  ASN   A O   1 
ATOM   1019 C  CB  A ASN   A 1  131 ? -15.167 25.34   -25.587 0.5  23.466  ? 167  ASN   A CB  1 
ATOM   1020 C  CB  B ASN   A 1  131 ? -14.942 25.515  -25.484 0.5  23.264  ? 167  ASN   A CB  1 
ATOM   1021 C  CG  A ASN   A 1  131 ? -16.17  26.226  -26.301 0.5  24.741  ? 167  ASN   A CG  1 
ATOM   1022 C  CG  B ASN   A 1  131 ? -15.984 24.973  -24.527 0.5  25.031  ? 167  ASN   A CG  1 
ATOM   1023 O  OD1 A ASN   A 1  131 ? -17.297 25.812  -26.584 0.5  28.752  ? 167  ASN   A OD1 1 
ATOM   1024 O  OD1 B ASN   A 1  131 ? -16.383 23.814  -24.654 0.5  23.217  ? 167  ASN   A OD1 1 
ATOM   1025 N  ND2 A ASN   A 1  131 ? -15.813 27.475  -26.55  0.5  24.543  ? 167  ASN   A ND2 1 
ATOM   1026 N  ND2 B ASN   A 1  131 ? -16.412 25.768  -23.548 0.5  27.173  ? 167  ASN   A ND2 1 
ATOM   1027 N  N   . VAL   A 1  132 ? -12.443 25.565  -27.46  1    20.758  ? 168  VAL   A N   1 
ATOM   1028 C  CA  . VAL   A 1  132 ? -11.677 26.103  -28.596 1    19.591  ? 168  VAL   A CA  1 
ATOM   1029 C  C   . VAL   A 1  132 ? -11.55  25.096  -29.762 1    19.086  ? 168  VAL   A C   1 
ATOM   1030 O  O   . VAL   A 1  132 ? -11.788 25.435  -30.928 1    21.164  ? 168  VAL   A O   1 
ATOM   1031 C  CB  . VAL   A 1  132 ? -10.29  26.706  -28.252 1    24.627  ? 168  VAL   A CB  1 
ATOM   1032 C  CG1 . VAL   A 1  132 ? -9.498  27.038  -29.532 1    22.058  ? 168  VAL   A CG1 1 
ATOM   1033 C  CG2 . VAL   A 1  132 ? -10.349 27.94   -27.314 1    21.852  ? 168  VAL   A CG2 1 
ATOM   1034 N  N   . MET   A 1  133 ? -11.113 23.854  -29.488 1    20.474  ? 169  MET   A N   1 
ATOM   1035 C  CA  . MET   A 1  133 ? -10.956 22.824  -30.528 1    21.325  ? 169  MET   A CA  1 
ATOM   1036 C  C   . MET   A 1  133 ? -12.308 22.506  -31.193 1    20.55   ? 169  MET   A C   1 
ATOM   1037 O  O   . MET   A 1  133 ? -12.372 22.261  -32.407 1    22.646  ? 169  MET   A O   1 
ATOM   1038 C  CB  . MET   A 1  133 ? -10.372 21.529  -29.926 1    17.848  ? 169  MET   A CB  1 
ATOM   1039 C  CG  . MET   A 1  133 ? -8.899  21.783  -29.349 1    19.004  ? 169  MET   A CG  1 
ATOM   1040 S  SD  . MET   A 1  133 ? -7.706  22.541  -30.464 1    21.559  ? 169  MET   A SD  1 
ATOM   1041 C  CE  . MET   A 1  133 ? -7.579  21.266  -31.744 1    19.147  ? 169  MET   A CE  1 
ATOM   1042 N  N   . ALA   A 1  134 ? -13.382 22.489  -30.403 1    19.151  ? 170  ALA   A N   1 
ATOM   1043 C  CA  . ALA   A 1  134 ? -14.713 22.179  -30.932 1    22.068  ? 170  ALA   A CA  1 
ATOM   1044 C  C   . ALA   A 1  134 ? -15.254 23.299  -31.821 1    24.327  ? 170  ALA   A C   1 
ATOM   1045 O  O   . ALA   A 1  134 ? -15.976 22.994  -32.749 1    24.323  ? 170  ALA   A O   1 
ATOM   1046 C  CB  . ALA   A 1  134 ? -15.735 21.911  -29.827 1    19.714  ? 170  ALA   A CB  1 
ATOM   1047 N  N   . THR   A 1  135 ? -14.951 24.57   -31.544 1    18.534  ? 171  THR   A N   1 
ATOM   1048 C  CA  . THR   A 1  135 ? -15.786 25.582  -32.162 1    21.66   ? 171  THR   A CA  1 
ATOM   1049 C  C   . THR   A 1  135 ? -14.976 26.507  -33.043 1    21.225  ? 171  THR   A C   1 
ATOM   1050 O  O   . THR   A 1  135 ? -15.537 27.01   -34.018 1    22.47   ? 171  THR   A O   1 
ATOM   1051 C  CB  . THR   A 1  135 ? -16.562 26.394  -31.102 1    25.907  ? 171  THR   A CB  1 
ATOM   1052 O  OG1 . THR   A 1  135 ? -15.533 26.988  -30.331 1    27.202  ? 171  THR   A OG1 1 
ATOM   1053 C  CG2 . THR   A 1  135 ? -17.53  25.55   -30.277 1    25.636  ? 171  THR   A CG2 1 
ATOM   1054 N  N   . SER   A 1  136 ? -13.673 26.658  -32.787 1    21.92   ? 172  SER   A N   1 
ATOM   1055 C  CA  . SER   A 1  136 ? -12.895 27.57   -33.593 1    19.418  ? 172  SER   A CA  1 
ATOM   1056 C  C   . SER   A 1  136 ? -12.779 27.045  -35.011 1    19.747  ? 172  SER   A C   1 
ATOM   1057 O  O   . SER   A 1  136 ? -12.517 25.851  -35.194 1    19.27   ? 172  SER   A O   1 
ATOM   1058 C  CB  . SER   A 1  136 ? -11.507 27.817  -33.025 1    20.363  ? 172  SER   A CB  1 
ATOM   1059 O  OG  . SER   A 1  136 ? -10.765 28.667  -33.931 1    18.994  ? 172  SER   A OG  1 
ATOM   1060 N  N   . ARG   A 1  137 ? -12.783 27.96   -35.995 1    21.569  ? 173  ARG   A N   1 
ATOM   1061 C  CA  . ARG   A 1  137 ? -12.551 27.606  -37.39  1    25.82   ? 173  ARG   A CA  1 
ATOM   1062 C  C   . ARG   A 1  137 ? -11.4   28.444  -37.945 1    28.422  ? 173  ARG   A C   1 
ATOM   1063 O  O   . ARG   A 1  137 ? -11.259 28.547  -39.148 1    22.201  ? 173  ARG   A O   1 
ATOM   1064 C  CB  . ARG   A 1  137 ? -13.826 27.673  -38.25  1    27.177  ? 173  ARG   A CB  1 
ATOM   1065 C  CG  . ARG   A 1  137 ? -15.011 26.831  -37.757 1    23.804  ? 173  ARG   A CG  1 
ATOM   1066 C  CD  . ARG   A 1  137 ? -14.712 25.315  -38.009 1    23.608  ? 173  ARG   A CD  1 
ATOM   1067 N  NE  . ARG   A 1  137 ? -15.895 24.588  -37.518 1    27.508  ? 173  ARG   A NE  1 
ATOM   1068 C  CZ  . ARG   A 1  137 ? -16.111 23.808  -36.432 1    32.954  ? 173  ARG   A CZ  1 
ATOM   1069 N  NH1 . ARG   A 1  137 ? -17.345 23.348  -36.243 1    32.622  ? 173  ARG   A NH1 1 
ATOM   1070 N  NH2 . ARG   A 1  137 ? -15.17  23.527  -35.521 1    29.331  ? 173  ARG   A NH2 1 
ATOM   1071 N  N   . LYS   A 1  138 ? -10.557 29.01   -37.069 1    26.487  ? 174  LYS   A N   1 
ATOM   1072 C  CA  . LYS   A 1  138 ? -9.377  29.746  -37.501 1    26.266  ? 174  LYS   A CA  1 
ATOM   1073 C  C   . LYS   A 1  138 ? -8.124  28.887  -37.272 1    26.007  ? 174  LYS   A C   1 
ATOM   1074 O  O   . LYS   A 1  138 ? -7.855  28.439  -36.138 1    21.638  ? 174  LYS   A O   1 
ATOM   1075 C  CB  . LYS   A 1  138 ? -9.382  31.005  -36.63  1    24.484  ? 174  LYS   A CB  1 
ATOM   1076 C  CG  . LYS   A 1  138 ? -10.638 31.841  -36.99  1    29.451  ? 174  LYS   A CG  1 
ATOM   1077 C  CD  . LYS   A 1  138 ? -10.634 33.282  -36.525 1    41.017  ? 174  LYS   A CD  1 
ATOM   1078 C  CE  . LYS   A 1  138 ? -9.48   34.089  -37.031 1    46.191  ? 174  LYS   A CE  1 
ATOM   1079 N  NZ  . LYS   A 1  138 ? -9.322  35.172  -36.057 1    52.863  ? 174  LYS   A NZ  1 
ATOM   1080 N  N   . TYR   A 1  139 ? -7.349  28.661  -38.351 1    19.991  ? 175  TYR   A N   1 
ATOM   1081 C  CA  . TYR   A 1  139 ? -6.27   27.678  -38.319 1    22.062  ? 175  TYR   A CA  1 
ATOM   1082 C  C   . TYR   A 1  139 ? -5.297  28.012  -37.176 1    19.829  ? 175  TYR   A C   1 
ATOM   1083 O  O   . TYR   A 1  139 ? -4.763  27.144  -36.481 1    20.705  ? 175  TYR   A O   1 
ATOM   1084 C  CB  . TYR   A 1  139 ? -5.565  27.746  -39.692 1    22.825  ? 175  TYR   A CB  1 
ATOM   1085 C  CG  . TYR   A 1  139 ? -4.553  26.648  -39.995 1    25.816  ? 175  TYR   A CG  1 
ATOM   1086 C  CD1 . TYR   A 1  139 ? -3.235  26.707  -39.549 1    25.699  ? 175  TYR   A CD1 1 
ATOM   1087 C  CD2 . TYR   A 1  139 ? -4.935  25.549  -40.767 1    25.548  ? 175  TYR   A CD2 1 
ATOM   1088 C  CE1 . TYR   A 1  139 ? -2.307  25.711  -39.852 1    23.907  ? 175  TYR   A CE1 1 
ATOM   1089 C  CE2 . TYR   A 1  139 ? -4.034  24.528  -41.047 1    23.863  ? 175  TYR   A CE2 1 
ATOM   1090 C  CZ  . TYR   A 1  139 ? -2.722  24.61   -40.586 1    27.65   ? 175  TYR   A CZ  1 
ATOM   1091 O  OH  . TYR   A 1  139 ? -1.902  23.558  -40.911 1    25.114  ? 175  TYR   A OH  1 
ATOM   1092 N  N   . GLU   A 1  140 ? -4.981  29.292  -37.042 1    23.881  ? 176  GLU   A N   1 
ATOM   1093 C  CA  . GLU   A 1  140 ? -3.918  29.695  -36.11  1    23.073  ? 176  GLU   A CA  1 
ATOM   1094 C  C   . GLU   A 1  140 ? -4.44   29.636  -34.663 1    20.665  ? 176  GLU   A C   1 
ATOM   1095 O  O   . GLU   A 1  140 ? -3.633  29.46   -33.776 1    23.202  ? 176  GLU   A O   1 
ATOM   1096 C  CB  . GLU   A 1  140 ? -3.414  31.124  -36.342 1    25.484  ? 176  GLU   A CB  1 
ATOM   1097 C  CG  . GLU   A 1  140 ? -2.848  31.346  -37.751 1    29.4    ? 176  GLU   A CG  1 
ATOM   1098 C  CD  . GLU   A 1  140 ? -1.529  30.598  -37.903 1    38.58   ? 176  GLU   A CD  1 
ATOM   1099 O  OE1 . GLU   A 1  140 ? -0.8    30.522  -36.847 1    35.196  ? 176  GLU   A OE1 1 
ATOM   1100 O  OE2 . GLU   A 1  140 ? -1.271  30.07   -39.023 1    32.732  ? 176  GLU   A OE2 1 
ATOM   1101 N  N   . ASP   A 1  141 ? -5.741  29.83   -34.393 1    17.888  ? 177  ASP   A N   1 
ATOM   1102 C  CA  . ASP   A 1  141 ? -6.246  29.731  -33.008 1    20.331  ? 177  ASP   A CA  1 
ATOM   1103 C  C   . ASP   A 1  141 ? -6.27   28.237  -32.588 1    18.607  ? 177  ASP   A C   1 
ATOM   1104 O  O   . ASP   A 1  141 ? -6.005  27.874  -31.434 1    19.97   ? 177  ASP   A O   1 
ATOM   1105 C  CB  . ASP   A 1  141 ? -7.651  30.321  -32.93  1    20.711  ? 177  ASP   A CB  1 
ATOM   1106 C  CG  . ASP   A 1  141 ? -7.726  31.855  -33.049 1    28.398  ? 177  ASP   A CG  1 
ATOM   1107 O  OD1 . ASP   A 1  141 ? -6.681  32.509  -33.049 1    30.37   ? 177  ASP   A OD1 1 
ATOM   1108 O  OD2 . ASP   A 1  141 ? -8.823  32.406  -33.198 1    30.627  ? 177  ASP   A OD2 1 
ATOM   1109 N  N   . LEU   A 1  142 ? -6.646  27.372  -33.543 1    20.37   ? 178  LEU   A N   1 
ATOM   1110 C  CA  . LEU   A 1  142 ? -6.676  25.937  -33.309 1    17.322  ? 178  LEU   A CA  1 
ATOM   1111 C  C   . LEU   A 1  142 ? -5.248  25.491  -33.06  1    18.29   ? 178  LEU   A C   1 
ATOM   1112 O  O   . LEU   A 1  142 ? -5.012  24.684  -32.163 1    21.372  ? 178  LEU   A O   1 
ATOM   1113 C  CB  . LEU   A 1  142 ? -7.285  25.236  -34.501 1    14.884  ? 178  LEU   A CB  1 
ATOM   1114 C  CG  . LEU   A 1  142 ? -8.794  25.461  -34.649 1    16.199  ? 178  LEU   A CG  1 
ATOM   1115 C  CD1 . LEU   A 1  142 ? -9.116  24.914  -36.077 1    19.871  ? 178  LEU   A CD1 1 
ATOM   1116 C  CD2 . LEU   A 1  142 ? -9.488  24.674  -33.511 1    14.301  ? 178  LEU   A CD2 1 
ATOM   1117 N  N   . LEU   A 1  143 ? -4.319  26.068  -33.827 1    18.239  ? 179  LEU   A N   1 
ATOM   1118 C  CA  . LEU   A 1  143 ? -2.928  25.682  -33.625 1    20.528  ? 179  LEU   A CA  1 
ATOM   1119 C  C   . LEU   A 1  143 ? -2.41   26.097  -32.26  1    19.57   ? 179  LEU   A C   1 
ATOM   1120 O  O   . LEU   A 1  143 ? -1.704  25.342  -31.591 1    19.571  ? 179  LEU   A O   1 
ATOM   1121 C  CB  . LEU   A 1  143 ? -2.056  26.181  -34.773 1    21.424  ? 179  LEU   A CB  1 
ATOM   1122 C  CG  . LEU   A 1  143 ? -0.559  25.915  -34.614 1    28.199  ? 179  LEU   A CG  1 
ATOM   1123 C  CD1 . LEU   A 1  143 ? -0.484  24.448  -34.709 1    30.074  ? 179  LEU   A CD1 1 
ATOM   1124 C  CD2 . LEU   A 1  143 ? 0.128   26.481  -35.8   1    34.145  ? 179  LEU   A CD2 1 
ATOM   1125 N  N   . TRP   A 1  144 ? -2.733  27.316  -31.867 1    20.031  ? 180  TRP   A N   1 
ATOM   1126 C  CA  . TRP   A 1  144 ? -2.348  27.787  -30.538 1    24.768  ? 180  TRP   A CA  1 
ATOM   1127 C  C   . TRP   A 1  144 ? -2.845  26.805  -29.446 1    20.98   ? 180  TRP   A C   1 
ATOM   1128 O  O   . TRP   A 1  144 ? -2.104  26.445  -28.513 1    17.826  ? 180  TRP   A O   1 
ATOM   1129 C  CB  . TRP   A 1  144 ? -2.847  29.243  -30.354 1    25.057  ? 180  TRP   A CB  1 
ATOM   1130 C  CG  . TRP   A 1  144 ? -2.571  29.814  -28.985 1    29.702  ? 180  TRP   A CG  1 
ATOM   1131 C  CD1 . TRP   A 1  144 ? -1.414  30.441  -28.607 1    30.896  ? 180  TRP   A CD1 1 
ATOM   1132 C  CD2 . TRP   A 1  144 ? -3.393  29.704  -27.78  1    29.922  ? 180  TRP   A CD2 1 
ATOM   1133 N  NE1 . TRP   A 1  144 ? -1.471  30.753  -27.266 1    31.569  ? 180  TRP   A NE1 1 
ATOM   1134 C  CE2 . TRP   A 1  144 ? -2.666  30.315  -26.732 1    32.805  ? 180  TRP   A CE2 1 
ATOM   1135 C  CE3 . TRP   A 1  144 ? -4.674  29.205  -27.471 1    32.871  ? 180  TRP   A CE3 1 
ATOM   1136 C  CZ2 . TRP   A 1  144 ? -3.164  30.351  -25.415 1    41.506  ? 180  TRP   A CZ2 1 
ATOM   1137 C  CZ3 . TRP   A 1  144 ? -5.172  29.248  -26.175 1    33.227  ? 180  TRP   A CZ3 1 
ATOM   1138 C  CH2 . TRP   A 1  144 ? -4.406  29.793  -25.145 1    40.776  ? 180  TRP   A CH2 1 
ATOM   1139 N  N   . ALA   A 1  145 ? -4.118  26.367  -29.531 1    20.558  ? 181  ALA   A N   1 
ATOM   1140 C  CA  . ALA   A 1  145 ? -4.662  25.549  -28.44  1    19.979  ? 181  ALA   A CA  1 
ATOM   1141 C  C   . ALA   A 1  145 ? -3.996  24.186  -28.486 1    20.072  ? 181  ALA   A C   1 
ATOM   1142 O  O   . ALA   A 1  145 ? -3.626  23.622  -27.463 1    19.309  ? 181  ALA   A O   1 
ATOM   1143 C  CB  . ALA   A 1  145 ? -6.207  25.404  -28.532 1    18.241  ? 181  ALA   A CB  1 
ATOM   1144 N  N   . TRP   A 1  146 ? -3.761  23.711  -29.705 1    18.32   ? 182  TRP   A N   1 
ATOM   1145 C  CA  . TRP   A 1  146 ? -3.296  22.353  -29.9   1    18.991  ? 182  TRP   A CA  1 
ATOM   1146 C  C   . TRP   A 1  146 ? -1.831  22.276  -29.428 1    20.908  ? 182  TRP   A C   1 
ATOM   1147 O  O   . TRP   A 1  146 ? -1.439  21.353  -28.687 1    19.429  ? 182  TRP   A O   1 
ATOM   1148 C  CB  . TRP   A 1  146 ? -3.378  22.043  -31.406 1    18.308  ? 182  TRP   A CB  1 
ATOM   1149 C  CG  . TRP   A 1  146 ? -2.963  20.616  -31.748 1    15.696  ? 182  TRP   A CG  1 
ATOM   1150 C  CD1 . TRP   A 1  146 ? -3.782  19.529  -31.909 1    20.127  ? 182  TRP   A CD1 1 
ATOM   1151 C  CD2 . TRP   A 1  146 ? -1.631  20.157  -32.046 1    18.465  ? 182  TRP   A CD2 1 
ATOM   1152 N  NE1 . TRP   A 1  146 ? -3.057  18.384  -32.227 1    18.463  ? 182  TRP   A NE1 1 
ATOM   1153 C  CE2 . TRP   A 1  146 ? -1.718  18.753  -32.312 1    20.573  ? 182  TRP   A CE2 1 
ATOM   1154 C  CE3 . TRP   A 1  146 ? -0.376  20.792  -32.122 1    19.474  ? 182  TRP   A CE3 1 
ATOM   1155 C  CZ2 . TRP   A 1  146 ? -0.588  17.994  -32.637 1    18.583  ? 182  TRP   A CZ2 1 
ATOM   1156 C  CZ3 . TRP   A 1  146 ? 0.742   20.024  -32.444 1    19.381  ? 182  TRP   A CZ3 1 
ATOM   1157 C  CH2 . TRP   A 1  146 ? 0.642   18.637  -32.692 1    18.714  ? 182  TRP   A CH2 1 
ATOM   1158 N  N   . GLU   A 1  147 ? -1.037  23.248  -29.857 1    18.328  ? 183  GLU   A N   1 
ATOM   1159 C  CA  . GLU   A 1  147 ? 0.4     23.267  -29.555 1    20.417  ? 183  GLU   A CA  1 
ATOM   1160 C  C   . GLU   A 1  147 ? 0.564   23.579  -28.05  1    22.757  ? 183  GLU   A C   1 
ATOM   1161 O  O   . GLU   A 1  147 ? 1.444   23      -27.394 1    24.98   ? 183  GLU   A O   1 
ATOM   1162 C  CB  . GLU   A 1  147 ? 1.149   24.334  -30.358 1    21.385  ? 183  GLU   A CB  1 
ATOM   1163 C  CG  . GLU   A 1  147 ? 2.674   24.3    -30.169 1    24.713  ? 183  GLU   A CG  1 
ATOM   1164 C  CD  . GLU   A 1  147 ? 3.322   22.941  -30.531 1    28.642  ? 183  GLU   A CD  1 
ATOM   1165 O  OE1 . GLU   A 1  147 ? 3.075   22.42   -31.643 1    28.4    ? 183  GLU   A OE1 1 
ATOM   1166 O  OE2 . GLU   A 1  147 ? 4.06    22.329  -29.681 1    31.435  ? 183  GLU   A OE2 1 
ATOM   1167 N  N   . GLY   A 1  148 ? -0.225  24.556  -27.545 1    24.164  ? 184  GLY   A N   1 
ATOM   1168 C  CA  . GLY   A 1  148 ? -0.099  25.024  -26.161 1    25.926  ? 184  GLY   A CA  1 
ATOM   1169 C  C   . GLY   A 1  148 ? -0.335  23.849  -25.202 1    22.623  ? 184  GLY   A C   1 
ATOM   1170 O  O   . GLY   A 1  148 ? 0.404   23.626  -24.257 1    19.335  ? 184  GLY   A O   1 
ATOM   1171 N  N   . TRP   A 1  149 ? -1.359  23.049  -25.505 1    21.511  ? 185  TRP   A N   1 
ATOM   1172 C  CA  . TRP   A 1  149 ? -1.736  21.962  -24.617 1    20.488  ? 185  TRP   A CA  1 
ATOM   1173 C  C   . TRP   A 1  149 ? -0.581  20.957  -24.591 1    16.767  ? 185  TRP   A C   1 
ATOM   1174 O  O   . TRP   A 1  149 ? -0.123  20.503  -23.522 1    20.347  ? 185  TRP   A O   1 
ATOM   1175 C  CB  . TRP   A 1  149 ? -3.074  21.308  -25.077 1    13.695  ? 185  TRP   A CB  1 
ATOM   1176 C  CG  . TRP   A 1  149 ? -3.447  20.128  -24.225 1    16.794  ? 185  TRP   A CG  1 
ATOM   1177 C  CD1 . TRP   A 1  149 ? -3.527  18.796  -24.576 1    14.532  ? 185  TRP   A CD1 1 
ATOM   1178 C  CD2 . TRP   A 1  149 ? -3.642  20.183  -22.806 1    16.076  ? 185  TRP   A CD2 1 
ATOM   1179 N  NE1 . TRP   A 1  149 ? -3.771  18.036  -23.455 1    16.379  ? 185  TRP   A NE1 1 
ATOM   1180 C  CE2 . TRP   A 1  149 ? -3.857  18.85   -22.366 1    16.19   ? 185  TRP   A CE2 1 
ATOM   1181 C  CE3 . TRP   A 1  149 ? -3.734  21.228  -21.88  1    18.458  ? 185  TRP   A CE3 1 
ATOM   1182 C  CZ2 . TRP   A 1  149 ? -4.142  18.549  -21.034 1    17.357  ? 185  TRP   A CZ2 1 
ATOM   1183 C  CZ3 . TRP   A 1  149 ? -4.045  20.932  -20.57  1    20.612  ? 185  TRP   A CZ3 1 
ATOM   1184 C  CH2 . TRP   A 1  149 ? -4.149  19.591  -20.144 1    21.16   ? 185  TRP   A CH2 1 
ATOM   1185 N  N   . ARG   A 1  150 ? -0.003  20.717  -25.761 1    17.214  ? 186  ARG   A N   1 
ATOM   1186 C  CA  . ARG   A 1  150 ? 1.113   19.798  -25.839 1    21.196  ? 186  ARG   A CA  1 
ATOM   1187 C  C   . ARG   A 1  150 ? 2.331   20.396  -25.126 1    23.901  ? 186  ARG   A C   1 
ATOM   1188 O  O   . ARG   A 1  150 ? 2.999   19.699  -24.375 1    22.717  ? 186  ARG   A O   1 
ATOM   1189 C  CB  . ARG   A 1  150 ? 1.457   19.309  -27.259 1    18.892  ? 186  ARG   A CB  1 
ATOM   1190 C  CG  . ARG   A 1  150 ? 0.381   18.277  -27.596 1    20.049  ? 186  ARG   A CG  1 
ATOM   1191 C  CD  . ARG   A 1  150 ? 0.191   18.287  -29.117 1    19.658  ? 186  ARG   A CD  1 
ATOM   1192 N  NE  . ARG   A 1  150 ? -0.901  17.321  -29.352 1    21.461  ? 186  ARG   A NE  1 
ATOM   1193 C  CZ  . ARG   A 1  150 ? -2.193  17.507  -29.171 1    18.282  ? 186  ARG   A CZ  1 
ATOM   1194 N  NH1 . ARG   A 1  150 ? -3.025  16.485  -29.373 1    19.912  ? 186  ARG   A NH1 1 
ATOM   1195 N  NH2 . ARG   A 1  150 ? -2.636  18.674  -28.814 1    18.465  ? 186  ARG   A NH2 1 
ATOM   1196 N  N   . ASP   A 1  151 ? 2.668   21.673  -25.39  1    20.874  ? 187  ASP   A N   1 
ATOM   1197 C  CA  . ASP   A 1  151 ? 3.799   22.267  -24.672 1    23.012  ? 187  ASP   A CA  1 
ATOM   1198 C  C   . ASP   A 1  151 ? 3.642   22.176  -23.146 1    23.75   ? 187  ASP   A C   1 
ATOM   1199 O  O   . ASP   A 1  151 ? 4.639   22.033  -22.421 1    21.122  ? 187  ASP   A O   1 
ATOM   1200 C  CB  . ASP   A 1  151 ? 3.927   23.745  -25.06  1    23.109  ? 187  ASP   A CB  1 
ATOM   1201 C  CG  . ASP   A 1  151 ? 4.179   23.948  -26.549 1    28.493  ? 187  ASP   A CG  1 
ATOM   1202 O  OD1 . ASP   A 1  151 ? 4.594   22.955  -27.25  1    26.168  ? 187  ASP   A OD1 1 
ATOM   1203 O  OD2 . ASP   A 1  151 ? 4.077   25.097  -26.995 1    23.943  ? 187  ASP   A OD2 1 
ATOM   1204 N  N   . LYS   A 1  152 ? 2.412   22.334  -22.624 1    22.111  ? 188  LYS   A N   1 
ATOM   1205 C  CA  . LYS   A 1  152 ? 2.22    22.502  -21.183 1    24.127  ? 188  LYS   A CA  1 
ATOM   1206 C  C   . LYS   A 1  152 ? 2.004   21.164  -20.507 1    31.643  ? 188  LYS   A C   1 
ATOM   1207 O  O   . LYS   A 1  152 ? 2.612   20.908  -19.484 1    30.304  ? 188  LYS   A O   1 
ATOM   1208 C  CB  . LYS   A 1  152 ? 1.139   23.427  -20.615 1    25.45   ? 188  LYS   A CB  1 
ATOM   1209 C  CG  . LYS   A 1  152 ? 1.297   24.88   -21.162 1    36.97   ? 188  LYS   A CG  1 
ATOM   1210 C  CD  . LYS   A 1  152 ? 2.523   25.588  -20.575 1    42.945  ? 188  LYS   A CD  1 
ATOM   1211 C  CE  . LYS   A 1  152 ? 2.373   25.77   -19.093 1    40.35   ? 188  LYS   A CE  1 
ATOM   1212 N  NZ  . LYS   A 1  152 ? 1.407   26.797  -18.658 1    42.904  ? 188  LYS   A NZ  1 
ATOM   1213 N  N   . ALA   A 1  153 ? 1.132   20.333  -21.069 1    25.613  ? 189  ALA   A N   1 
ATOM   1214 C  CA  . ALA   A 1  153 ? 0.869   19.04   -20.461 1    25.529  ? 189  ALA   A CA  1 
ATOM   1215 C  C   . ALA   A 1  153 ? 1.838   17.966  -20.937 1    22.509  ? 189  ALA   A C   1 
ATOM   1216 O  O   . ALA   A 1  153 ? 2.387   17.219  -20.114 1    24.494  ? 189  ALA   A O   1 
ATOM   1217 C  CB  . ALA   A 1  153 ? -0.549  18.647  -20.781 1    27.241  ? 189  ALA   A CB  1 
ATOM   1218 N  N   . GLY   A 1  154 ? 1.998   17.798  -22.259 1    20.719  ? 190  GLY   A N   1 
ATOM   1219 C  CA  . GLY   A 1  154 ? 2.823   16.699  -22.703 1    19.325  ? 190  GLY   A CA  1 
ATOM   1220 C  C   . GLY   A 1  154 ? 4.291   16.889  -22.318 1    24.762  ? 190  GLY   A C   1 
ATOM   1221 O  O   . GLY   A 1  154 ? 4.913   15.95   -21.809 1    21.26   ? 190  GLY   A O   1 
ATOM   1222 N  N   . ARG   A 1  155 ? 4.852   18.097  -22.5   1    19.791  ? 191  ARG   A N   1 
ATOM   1223 C  CA  . ARG   A 1  155 ? 6.279   18.178  -22.206 1    22.582  ? 191  ARG   A CA  1 
ATOM   1224 C  C   . ARG   A 1  155 ? 6.526   17.922  -20.723 1    22.037  ? 191  ARG   A C   1 
ATOM   1225 O  O   . ARG   A 1  155 ? 7.609   17.497  -20.352 1    23.284  ? 191  ARG   A O   1 
ATOM   1226 C  CB  . ARG   A 1  155 ? 6.898   19.552  -22.561 1    21.124  ? 191  ARG   A CB  1 
ATOM   1227 C  CG  . ARG   A 1  155 ? 6.901   19.711  -24.08  1    24.686  ? 191  ARG   A CG  1 
ATOM   1228 C  CD  . ARG   A 1  155 ? 7.153   21.176  -24.537 1    28.978  ? 191  ARG   A CD  1 
ATOM   1229 N  NE  . ARG   A 1  155 ? 8.58    21.364  -24.287 1    34.71   ? 191  ARG   A NE  1 
ATOM   1230 C  CZ  . ARG   A 1  155 ? 9.64    21.017  -25.057 1    40.915  ? 191  ARG   A CZ  1 
ATOM   1231 N  NH1 . ARG   A 1  155 ? 10.889  21.318  -24.665 1    40.787  ? 191  ARG   A NH1 1 
ATOM   1232 N  NH2 . ARG   A 1  155 ? 9.466   20.406  -26.224 1    36.366  ? 191  ARG   A NH2 1 
ATOM   1233 N  N   . ALA   A 1  156 ? 5.594   18.335  -19.864 1    21.007  ? 192  ALA   A N   1 
ATOM   1234 C  CA  . ALA   A 1  156 ? 5.783   18.261  -18.421 1    22.503  ? 192  ALA   A CA  1 
ATOM   1235 C  C   . ALA   A 1  156 ? 5.678   16.804  -17.979 1    24.759  ? 192  ALA   A C   1 
ATOM   1236 O  O   . ALA   A 1  156 ? 6.153   16.457  -16.901 1    23.336  ? 192  ALA   A O   1 
ATOM   1237 C  CB  . ALA   A 1  156 ? 4.71    19.115  -17.776 1    22.399  ? 192  ALA   A CB  1 
ATOM   1238 N  N   . ILE   A 1  157 ? 5.037   15.921  -18.766 1    19.765  ? 193  ILE   A N   1 
ATOM   1239 C  CA  . ILE   A 1  157 ? 4.972   14.517  -18.306 1    20.718  ? 193  ILE   A CA  1 
ATOM   1240 C  C   . ILE   A 1  157 ? 6.268   13.771  -18.633 1    22.143  ? 193  ILE   A C   1 
ATOM   1241 O  O   . ILE   A 1  157 ? 6.586   12.733  -18.037 1    21.55   ? 193  ILE   A O   1 
ATOM   1242 C  CB  . ILE   A 1  157 ? 3.768   13.816  -19.001 1    24.26   ? 193  ILE   A CB  1 
ATOM   1243 C  CG1 . ILE   A 1  157 ? 2.507   14.405  -18.493 1    23.422  ? 193  ILE   A CG1 1 
ATOM   1244 C  CG2 . ILE   A 1  157 ? 3.757   12.303  -18.787 1    23.893  ? 193  ILE   A CG2 1 
ATOM   1245 C  CD1 . ILE   A 1  157 ? 2.327   14.175  -16.983 1    24.68   ? 193  ILE   A CD1 1 
ATOM   1246 N  N   . LEU   A 1  158 ? 7.003   14.243  -19.657 1    21.068  ? 194  LEU   A N   1 
ATOM   1247 C  CA  . LEU   A 1  158 ? 8.172   13.539  -20.156 1    20.685  ? 194  LEU   A CA  1 
ATOM   1248 C  C   . LEU   A 1  158 ? 9.163   13.22   -19.034 1    22.258  ? 194  LEU   A C   1 
ATOM   1249 O  O   . LEU   A 1  158 ? 9.812   12.166  -19.074 1    20.976  ? 194  LEU   A O   1 
ATOM   1250 C  CB  . LEU   A 1  158 ? 8.897   14.299  -21.286 1    19.825  ? 194  LEU   A CB  1 
ATOM   1251 C  CG  . LEU   A 1  158 ? 10.145  13.613  -21.865 1    24.544  ? 194  LEU   A CG  1 
ATOM   1252 C  CD1 . LEU   A 1  158 ? 9.865   12.232  -22.431 1    20.73   ? 194  LEU   A CD1 1 
ATOM   1253 C  CD2 . LEU   A 1  158 ? 10.721  14.557  -22.931 1    20.63   ? 194  LEU   A CD2 1 
ATOM   1254 N  N   . GLN   A 1  159 ? 9.359   14.134  -18.059 1    24.615  ? 195  GLN   A N   1 
ATOM   1255 C  CA  . GLN   A 1  159 ? 10.412  13.868  -17.08  1    24      ? 195  GLN   A CA  1 
ATOM   1256 C  C   . GLN   A 1  159 ? 10.096  12.637  -16.22  1    25.239  ? 195  GLN   A C   1 
ATOM   1257 O  O   . GLN   A 1  159 ? 11.023  12.01   -15.681 1    24.74   ? 195  GLN   A O   1 
ATOM   1258 C  CB  . GLN   A 1  159 ? 10.539  15.072  -16.165 1    25.464  ? 195  GLN   A CB  1 
ATOM   1259 C  CG  . GLN   A 1  159 ? 9.264   15.313  -15.394 1    28.003  ? 195  GLN   A CG  1 
ATOM   1260 C  CD  . GLN   A 1  159 ? 9.252   16.593  -14.601 1    37.599  ? 195  GLN   A CD  1 
ATOM   1261 O  OE1 . GLN   A 1  159 ? 8.397   17.471  -14.801 1    55.961  ? 195  GLN   A OE1 1 
ATOM   1262 N  NE2 . GLN   A 1  159 ? 10.167  16.66   -13.658 1    31.447  ? 195  GLN   A NE2 1 
ATOM   1263 N  N   . PHE   A 1  160 ? 8.798   12.292  -16.057 1    20.602  ? 196  PHE   A N   1 
ATOM   1264 C  CA  . PHE   A 1  160 ? 8.342   11.108  -15.316 1    20.907  ? 196  PHE   A CA  1 
ATOM   1265 C  C   . PHE   A 1  160 ? 8.311   9.804   -16.115 1    19.943  ? 196  PHE   A C   1 
ATOM   1266 O  O   . PHE   A 1  160 ? 8.353   8.7     -15.549 1    19.174  ? 196  PHE   A O   1 
ATOM   1267 C  CB  . PHE   A 1  160 ? 6.898   11.354  -14.86  1    20.646  ? 196  PHE   A CB  1 
ATOM   1268 C  CG  . PHE   A 1  160 ? 6.795   12.614  -14.01  1    24.984  ? 196  PHE   A CG  1 
ATOM   1269 C  CD1 . PHE   A 1  160 ? 7.409   12.65   -12.747 1    27.565  ? 196  PHE   A CD1 1 
ATOM   1270 C  CD2 . PHE   A 1  160 ? 6.051   13.717  -14.429 1    21.215  ? 196  PHE   A CD2 1 
ATOM   1271 C  CE1 . PHE   A 1  160 ? 7.375   13.799  -11.945 1    27.244  ? 196  PHE   A CE1 1 
ATOM   1272 C  CE2 . PHE   A 1  160 ? 5.971   14.856  -13.623 1    27.712  ? 196  PHE   A CE2 1 
ATOM   1273 C  CZ  . PHE   A 1  160 ? 6.639   14.898  -12.384 1    29.229  ? 196  PHE   A CZ  1 
ATOM   1274 N  N   . TYR   A 1  161 ? 8.16    9.877   -17.442 1    21.265  ? 197  TYR   A N   1 
ATOM   1275 C  CA  . TYR   A 1  161 ? 7.696   8.702   -18.167 1    18.246  ? 197  TYR   A CA  1 
ATOM   1276 C  C   . TYR   A 1  161 ? 8.716   7.564   -18.147 1    17.45   ? 197  TYR   A C   1 
ATOM   1277 O  O   . TYR   A 1  161 ? 8.312   6.404   -18.003 1    17.894  ? 197  TYR   A O   1 
ATOM   1278 C  CB  . TYR   A 1  161 ? 7.203   9.093   -19.572 1    18.711  ? 197  TYR   A CB  1 
ATOM   1279 C  CG  . TYR   A 1  161 ? 6.07    8.148   -20.045 1    18.255  ? 197  TYR   A CG  1 
ATOM   1280 C  CD1 . TYR   A 1  161 ? 4.798   8.162   -19.472 1    22.568  ? 197  TYR   A CD1 1 
ATOM   1281 C  CD2 . TYR   A 1  161 ? 6.303   7.154   -20.99  1    22.192  ? 197  TYR   A CD2 1 
ATOM   1282 C  CE1 . TYR   A 1  161 ? 3.772   7.31    -19.921 1    23.99   ? 197  TYR   A CE1 1 
ATOM   1283 C  CE2 . TYR   A 1  161 ? 5.301   6.286   -21.432 1    20.084  ? 197  TYR   A CE2 1 
ATOM   1284 C  CZ  . TYR   A 1  161 ? 4.024   6.358   -20.905 1    22.418  ? 197  TYR   A CZ  1 
ATOM   1285 O  OH  . TYR   A 1  161 ? 3.074   5.437   -21.309 1    17.381  ? 197  TYR   A OH  1 
ATOM   1286 N  N   . PRO   A 1  162 ? 10.043  7.784   -18.416 1    21.603  ? 198  PRO   A N   1 
ATOM   1287 C  CA  . PRO   A 1  162 ? 10.963  6.646   -18.455 1    20.041  ? 198  PRO   A CA  1 
ATOM   1288 C  C   . PRO   A 1  162 ? 10.922  5.825   -17.157 1    17.144  ? 198  PRO   A C   1 
ATOM   1289 O  O   . PRO   A 1  162 ? 10.982  4.59    -17.166 1    21.378  ? 198  PRO   A O   1 
ATOM   1290 C  CB  . PRO   A 1  162 ? 12.356  7.331   -18.776 1    20.954  ? 198  PRO   A CB  1 
ATOM   1291 C  CG  . PRO   A 1  162 ? 11.992  8.623   -19.583 1    20.162  ? 198  PRO   A CG  1 
ATOM   1292 C  CD  . PRO   A 1  162 ? 10.687  9.053   -18.825 1    19.482  ? 198  PRO   A CD  1 
ATOM   1293 N  N   . LYS   A 1  163 ? 10.853  6.508   -16.004 1    18.685  ? 199  LYS   A N   1 
ATOM   1294 C  CA  . LYS   A 1  163 ? 10.873  5.831   -14.714 1    20.005  ? 199  LYS   A CA  1 
ATOM   1295 C  C   . LYS   A 1  163 ? 9.55    5.114   -14.474 1    21.759  ? 199  LYS   A C   1 
ATOM   1296 O  O   . LYS   A 1  163 ? 9.554   3.971   -13.976 1    22.241  ? 199  LYS   A O   1 
ATOM   1297 C  CB  . LYS   A 1  163 ? 11.142  6.904   -13.656 1    23.445  ? 199  LYS   A CB  1 
ATOM   1298 C  CG  . LYS   A 1  163 ? 11.373  6.365   -12.253 1    25.026  ? 199  LYS   A CG  1 
ATOM   1299 C  CD  . LYS   A 1  163 ? 12.369  5.203   -12.065 1    32.554  ? 199  LYS   A CD  1 
ATOM   1300 C  CE  . LYS   A 1  163 ? 13.865  5.486   -12.127 1    39.96   ? 199  LYS   A CE  1 
ATOM   1301 N  NZ  . LYS   A 1  163 ? 14.64   4.364   -11.55  1    35.383  ? 199  LYS   A NZ  1 
ATOM   1302 N  N   . TYR   A 1  164 ? 8.427   5.771   -14.876 1    21.658  ? 200  TYR   A N   1 
ATOM   1303 C  CA  . TYR   A 1  164 ? 7.165   5.041   -14.927 1    19.956  ? 200  TYR   A CA  1 
ATOM   1304 C  C   . TYR   A 1  164 ? 7.334   3.707   -15.672 1    17.044  ? 200  TYR   A C   1 
ATOM   1305 O  O   . TYR   A 1  164 ? 6.988   2.625   -15.146 1    21.754  ? 200  TYR   A O   1 
ATOM   1306 C  CB  . TYR   A 1  164 ? 6.146   5.994   -15.556 1    20.358  ? 200  TYR   A CB  1 
ATOM   1307 C  CG  . TYR   A 1  164 ? 4.942   5.234   -16.121 1    18.871  ? 200  TYR   A CG  1 
ATOM   1308 C  CD1 . TYR   A 1  164 ? 3.956   4.691   -15.25  1    16.403  ? 200  TYR   A CD1 1 
ATOM   1309 C  CD2 . TYR   A 1  164 ? 4.856   5.015   -17.494 1    16.611  ? 200  TYR   A CD2 1 
ATOM   1310 C  CE1 . TYR   A 1  164 ? 2.87    3.951   -15.726 1    19.567  ? 200  TYR   A CE1 1 
ATOM   1311 C  CE2 . TYR   A 1  164 ? 3.707   4.352   -17.986 1    19.987  ? 200  TYR   A CE2 1 
ATOM   1312 C  CZ  . TYR   A 1  164 ? 2.735   3.831   -17.12  1    17.869  ? 200  TYR   A CZ  1 
ATOM   1313 O  OH  . TYR   A 1  164 ? 1.654   3.191   -17.708 1    18.846  ? 200  TYR   A OH  1 
ATOM   1314 N  N   . VAL   A 1  165 ? 7.921   3.756   -16.876 1    16.721  ? 201  VAL   A N   1 
ATOM   1315 C  CA  . VAL   A 1  165 ? 7.992   2.574   -17.732 1    16.727  ? 201  VAL   A CA  1 
ATOM   1316 C  C   . VAL   A 1  165 ? 8.853   1.519   -17.045 1    20.529  ? 201  VAL   A C   1 
ATOM   1317 O  O   . VAL   A 1  165 ? 8.527   0.311   -17.026 1    20.317  ? 201  VAL   A O   1 
ATOM   1318 C  CB  . VAL   A 1  165 ? 8.574   2.962   -19.111 1    18.603  ? 201  VAL   A CB  1 
ATOM   1319 C  CG1 . VAL   A 1  165 ? 8.914   1.727   -19.979 1    15.93   ? 201  VAL   A CG1 1 
ATOM   1320 C  CG2 . VAL   A 1  165 ? 7.499   3.738   -19.862 1    16.21   ? 201  VAL   A CG2 1 
ATOM   1321 N  N   . GLU   A 1  166 ? 9.977   2       -16.493 1    20.422  ? 202  GLU   A N   1 
ATOM   1322 C  CA  . GLU   A 1  166 ? 10.83   1.034   -15.842 1    21.41   ? 202  GLU   A CA  1 
ATOM   1323 C  C   . GLU   A 1  166 ? 10.132  0.349   -14.656 1    20.532  ? 202  GLU   A C   1 
ATOM   1324 O  O   . GLU   A 1  166 ? 10.23   -0.871  -14.516 1    21.474  ? 202  GLU   A O   1 
ATOM   1325 C  CB  . GLU   A 1  166 ? 12.099  1.762   -15.373 1    23.194  ? 202  GLU   A CB  1 
ATOM   1326 C  CG  . GLU   A 1  166 ? 13.072  0.857   -14.608 1    31.922  ? 202  GLU   A CG  1 
ATOM   1327 C  CD  . GLU   A 1  166 ? 14.146  1.652   -13.854 1    39.725  ? 202  GLU   A CD  1 
ATOM   1328 O  OE1 . GLU   A 1  166 ? 14.561  2.709   -14.354 1    38.809  ? 202  GLU   A OE1 1 
ATOM   1329 O  OE2 . GLU   A 1  166 ? 14.542  1.252   -12.739 1    51.608  ? 202  GLU   A OE2 1 
ATOM   1330 N  N   . LEU   A 1  167 ? 9.429   1.102   -13.807 1    19.874  ? 203  LEU   A N   1 
ATOM   1331 C  CA  . LEU   A 1  167 ? 8.775   0.505   -12.644 1    20.809  ? 203  LEU   A CA  1 
ATOM   1332 C  C   . LEU   A 1  167 ? 7.573   -0.38   -13.027 1    21.865  ? 203  LEU   A C   1 
ATOM   1333 O  O   . LEU   A 1  167 ? 7.395   -1.471  -12.478 1    21.057  ? 203  LEU   A O   1 
ATOM   1334 C  CB  . LEU   A 1  167 ? 8.435   1.608   -11.656 1    24.322  ? 203  LEU   A CB  1 
ATOM   1335 C  CG  . LEU   A 1  167 ? 9.662   2.384   -11.156 1    27.979  ? 203  LEU   A CG  1 
ATOM   1336 C  CD1 . LEU   A 1  167 ? 9.245   3.491   -10.257 1    24.785  ? 203  LEU   A CD1 1 
ATOM   1337 C  CD2 . LEU   A 1  167 ? 10.674  1.468   -10.434 1    25.616  ? 203  LEU   A CD2 1 
ATOM   1338 N  N   . ILE   A 1  168 ? 6.754   0.048   -13.996 1    17.916  ? 204  ILE   A N   1 
ATOM   1339 C  CA  . ILE   A 1  168 ? 5.572   -0.752  -14.325 1    14.625  ? 204  ILE   A CA  1 
ATOM   1340 C  C   . ILE   A 1  168 ? 6.045   -2.04   -14.971 1    15.218  ? 204  ILE   A C   1 
ATOM   1341 O  O   . ILE   A 1  168 ? 5.448   -3.086  -14.743 1    18.147  ? 204  ILE   A O   1 
ATOM   1342 C  CB  . ILE   A 1  168 ? 4.481   0.002   -15.123 1    12.943  ? 204  ILE   A CB  1 
ATOM   1343 C  CG1 . ILE   A 1  168 ? 3.085   -0.737  -15.118 1    15.689  ? 204  ILE   A CG1 1 
ATOM   1344 C  CG2 . ILE   A 1  168 ? 4.959   0.336   -16.539 1    14.34   ? 204  ILE   A CG2 1 
ATOM   1345 C  CD1 . ILE   A 1  168 ? 2.028   0.068   -15.897 1    14.278  ? 204  ILE   A CD1 1 
ATOM   1346 N  N   . ASN   A 1  169 ? 7.11    -1.991  -15.759 1    18.1    ? 205  ASN   A N   1 
ATOM   1347 C  CA  . ASN   A 1  169 ? 7.613   -3.213  -16.39  1    17.517  ? 205  ASN   A CA  1 
ATOM   1348 C  C   . ASN   A 1  169 ? 8.221   -4.114  -15.312 1    19.132  ? 205  ASN   A C   1 
ATOM   1349 O  O   . ASN   A 1  169 ? 7.999   -5.349  -15.313 1    18.346  ? 205  ASN   A O   1 
ATOM   1350 C  CB  . ASN   A 1  169 ? 8.685   -2.865  -17.426 1    18.605  ? 205  ASN   A CB  1 
ATOM   1351 C  CG  . ASN   A 1  169 ? 8.13    -2.573  -18.814 1    21.266  ? 205  ASN   A CG  1 
ATOM   1352 O  OD1 . ASN   A 1  169 ? 6.966   -2.861  -19.1   1    19.189  ? 205  ASN   A OD1 1 
ATOM   1353 N  ND2 . ASN   A 1  169 ? 8.966   -2.044  -19.711 1    25.149  ? 205  ASN   A ND2 1 
ATOM   1354 N  N   . GLN   A 1  170 ? 8.933   -3.462  -14.362 1    19.762  ? 206  GLN   A N   1 
ATOM   1355 C  CA  . GLN   A 1  170 ? 9.563   -4.248  -13.274 1    21.5    ? 206  GLN   A CA  1 
ATOM   1356 C  C   . GLN   A 1  170 ? 8.481   -5.005  -12.48  1    22.399  ? 206  GLN   A C   1 
ATOM   1357 O  O   . GLN   A 1  170 ? 8.56    -6.221  -12.317 1    22.42   ? 206  GLN   A O   1 
ATOM   1358 C  CB  . GLN   A 1  170 ? 10.449  -3.363  -12.384 1    22.325  ? 206  GLN   A CB  1 
ATOM   1359 C  CG  . GLN   A 1  170 ? 11.181  -4.178  -11.305 1    25.809  ? 206  GLN   A CG  1 
ATOM   1360 C  CD  . GLN   A 1  170 ? 11.887  -3.356  -10.243 1    35.273  ? 206  GLN   A CD  1 
ATOM   1361 O  OE1 . GLN   A 1  170 ? 12.271  -3.878  -9.192  1    36.18   ? 206  GLN   A OE1 1 
ATOM   1362 N  NE2 . GLN   A 1  170 ? 12.036  -2.056  -10.448 1    27.22   ? 206  GLN   A NE2 1 
ATOM   1363 N  N   . ALA   A 1  171 ? 7.413   -4.288  -12.092 1    18.857  ? 207  ALA   A N   1 
ATOM   1364 C  CA  . ALA   A 1  171 ? 6.26    -4.972  -11.499 1    20.374  ? 207  ALA   A CA  1 
ATOM   1365 C  C   . ALA   A 1  171 ? 5.723   -6.113  -12.386 1    21.249  ? 207  ALA   A C   1 
ATOM   1366 O  O   . ALA   A 1  171 ? 5.441   -7.221  -11.879 1    21.264  ? 207  ALA   A O   1 
ATOM   1367 C  CB  . ALA   A 1  171 ? 5.181   -3.941  -11.137 1    16.315  ? 207  ALA   A CB  1 
ATOM   1368 N  N   . ALA   A 1  172 ? 5.561   -5.856  -13.715 1    19.774  ? 208  ALA   A N   1 
ATOM   1369 C  CA  . ALA   A 1  172 ? 5.027   -6.881  -14.599 1    19.462  ? 208  ALA   A CA  1 
ATOM   1370 C  C   . ALA   A 1  172 ? 5.866   -8.158  -14.543 1    18.427  ? 208  ALA   A C   1 
ATOM   1371 O  O   . ALA   A 1  172 ? 5.317   -9.293  -14.497 1    20.522  ? 208  ALA   A O   1 
ATOM   1372 C  CB  . ALA   A 1  172 ? 4.922   -6.371  -16.04  1    15.779  ? 208  ALA   A CB  1 
ATOM   1373 N  N   . ARG   A 1  173 ? 7.193   -7.941  -14.632 1    20.752  ? 209  ARG   A N   1 
ATOM   1374 C  CA  . ARG   A 1  173 ? 8.084   -9.121  -14.68  1    19.7    ? 209  ARG   A CA  1 
ATOM   1375 C  C   . ARG   A 1  173 ? 8.027   -9.876  -13.363 1    19.597  ? 209  ARG   A C   1 
ATOM   1376 O  O   . ARG   A 1  173 ? 7.991   -11.125 -13.329 1    18.984  ? 209  ARG   A O   1 
ATOM   1377 C  CB  . ARG   A 1  173 ? 9.585   -8.871  -14.948 1    21.317  ? 209  ARG   A CB  1 
ATOM   1378 C  CG  . ARG   A 1  173 ? 9.768   -8.081  -16.244 1    20.699  ? 209  ARG   A CG  1 
ATOM   1379 C  CD  . ARG   A 1  173 ? 11.25   -8.023  -16.586 1    23.257  ? 209  ARG   A CD  1 
ATOM   1380 N  NE  . ARG   A 1  173 ? 11.991  -7.278  -15.555 1    27.475  ? 209  ARG   A NE  1 
ATOM   1381 C  CZ  . ARG   A 1  173 ? 12.085  -5.931  -15.509 1    31.408  ? 209  ARG   A CZ  1 
ATOM   1382 N  NH1 . ARG   A 1  173 ? 11.55   -5.149  -16.458 1    27.558  ? 209  ARG   A NH1 1 
ATOM   1383 N  NH2 . ARG   A 1  173 ? 12.768  -5.351  -14.552 1    22.594  ? 209  ARG   A NH2 1 
ATOM   1384 N  N   . LEU   A 1  174 ? 7.929   -9.113  -12.257 1    22.069  ? 210  LEU   A N   1 
ATOM   1385 C  CA  . LEU   A 1  174 ? 7.868   -9.729  -10.926 1    22.839  ? 210  LEU   A CA  1 
ATOM   1386 C  C   . LEU   A 1  174 ? 6.546   -10.479 -10.761 1    27.909  ? 210  LEU   A C   1 
ATOM   1387 O  O   . LEU   A 1  174 ? 6.461   -11.435 -9.999  1    32.427  ? 210  LEU   A O   1 
ATOM   1388 C  CB  . LEU   A 1  174 ? 8.06    -8.703  -9.815  1    22.215  ? 210  LEU   A CB  1 
ATOM   1389 C  CG  . LEU   A 1  174 ? 9.489   -8.159  -9.69   1    22.506  ? 210  LEU   A CG  1 
ATOM   1390 C  CD1 . LEU   A 1  174 ? 9.387   -6.941  -8.784  1    21.331  ? 210  LEU   A CD1 1 
ATOM   1391 C  CD2 . LEU   A 1  174 ? 10.27   -9.294  -8.961  1    30.953  ? 210  LEU   A CD2 1 
ATOM   1392 N  N   . ASN   A 1  175 ? 5.577   -10.191 -11.622 1    21.483  ? 211  ASN   A N   1 
ATOM   1393 C  CA  . ASN   A 1  175 ? 4.39    -11.02  -11.599 1    19.413  ? 211  ASN   A CA  1 
ATOM   1394 C  C   . ASN   A 1  175 ? 4.372   -12.104 -12.689 1    21.763  ? 211  ASN   A C   1 
ATOM   1395 O  O   . ASN   A 1  175 ? 3.333   -12.659 -12.985 1    21.362  ? 211  ASN   A O   1 
ATOM   1396 C  CB  . ASN   A 1  175 ? 3.188   -10.086 -11.655 1    18.545  ? 211  ASN   A CB  1 
ATOM   1397 C  CG  . ASN   A 1  175 ? 2.999   -9.377  -10.325 1    21.667  ? 211  ASN   A CG  1 
ATOM   1398 O  OD1 . ASN   A 1  175 ? 2.798   -10.041 -9.293  1    24.313  ? 211  ASN   A OD1 1 
ATOM   1399 N  ND2 . ASN   A 1  175 ? 3.028   -8.047  -10.326 1    17.744  ? 211  ASN   A ND2 1 
ATOM   1400 N  N   . GLY   A 1  176 ? 5.428   -12.282 -13.445 1    23.03   ? 212  GLY   A N   1 
ATOM   1401 C  CA  . GLY   A 1  176 ? 5.43    -13.414 -14.354 1    22.306  ? 212  GLY   A CA  1 
ATOM   1402 C  C   . GLY   A 1  176 ? 5.192   -13.001 -15.812 1    21.929  ? 212  GLY   A C   1 
ATOM   1403 O  O   . GLY   A 1  176 ? 4.998   -13.895 -16.622 1    18.032  ? 212  GLY   A O   1 
ATOM   1404 N  N   . TYR   A 1  177 ? 5.074   -11.671 -16.085 1    19.717  ? 213  TYR   A N   1 
ATOM   1405 C  CA  . TYR   A 1  177 ? 4.794   -11.213 -17.451 1    21.082  ? 213  TYR   A CA  1 
ATOM   1406 C  C   . TYR   A 1  177 ? 6.136   -10.818 -18.067 1    21.718  ? 213  TYR   A C   1 
ATOM   1407 O  O   . TYR   A 1  177 ? 7.114   -10.663 -17.34  1    20.341  ? 213  TYR   A O   1 
ATOM   1408 C  CB  . TYR   A 1  177 ? 3.765   -10.044 -17.504 1    18.584  ? 213  TYR   A CB  1 
ATOM   1409 C  CG  . TYR   A 1  177 ? 2.398   -10.545 -17.055 1    18.795  ? 213  TYR   A CG  1 
ATOM   1410 C  CD1 . TYR   A 1  177 ? 1.528   -11.167 -17.965 1    22.978  ? 213  TYR   A CD1 1 
ATOM   1411 C  CD2 . TYR   A 1  177 ? 1.905   -10.283 -15.763 1    21.969  ? 213  TYR   A CD2 1 
ATOM   1412 C  CE1 . TYR   A 1  177 ? 0.28    -11.643 -17.576 1    22.888  ? 213  TYR   A CE1 1 
ATOM   1413 C  CE2 . TYR   A 1  177 ? 0.618   -10.696 -15.376 1    22.134  ? 213  TYR   A CE2 1 
ATOM   1414 C  CZ  . TYR   A 1  177 ? -0.157  -11.382 -16.281 1    27.598  ? 213  TYR   A CZ  1 
ATOM   1415 O  OH  . TYR   A 1  177 ? -1.366  -11.851 -15.914 1    33.146  ? 213  TYR   A OH  1 
ATOM   1416 N  N   . VAL   A 1  178 ? 6.197   -10.606 -19.389 1    20.5    ? 214  VAL   A N   1 
ATOM   1417 C  CA  . VAL   A 1  178 ? 7.476   -10.156 -19.872 1    21.224  ? 214  VAL   A CA  1 
ATOM   1418 C  C   . VAL   A 1  178 ? 7.662   -8.666  -19.736 1    19.943  ? 214  VAL   A C   1 
ATOM   1419 O  O   . VAL   A 1  178 ? 8.83    -8.217  -19.777 1    19.16   ? 214  VAL   A O   1 
ATOM   1420 C  CB  . VAL   A 1  178 ? 7.815   -10.641 -21.297 1    31.644  ? 214  VAL   A CB  1 
ATOM   1421 C  CG1 . VAL   A 1  178 ? 7.559   -12.143 -21.415 1    32.212  ? 214  VAL   A CG1 1 
ATOM   1422 C  CG2 . VAL   A 1  178 ? 7.088   -9.879  -22.361 1    30.615  ? 214  VAL   A CG2 1 
ATOM   1423 N  N   . ASP   A 1  179 ? 6.539   -7.905  -19.777 1    17.655  ? 215  ASP   A N   1 
ATOM   1424 C  CA  . ASP   A 1  179 ? 6.578   -6.453  -19.612 1    18.583  ? 215  ASP   A CA  1 
ATOM   1425 C  C   . ASP   A 1  179 ? 5.139   -5.988  -19.324 1    16.371  ? 215  ASP   A C   1 
ATOM   1426 O  O   . ASP   A 1  179 ? 4.247   -6.803  -19.291 1    15.83   ? 215  ASP   A O   1 
ATOM   1427 C  CB  . ASP   A 1  179 ? 7.147   -5.752  -20.836 1    18.045  ? 215  ASP   A CB  1 
ATOM   1428 C  CG  . ASP   A 1  179 ? 6.321   -6.011  -22.091 1    20.758  ? 215  ASP   A CG  1 
ATOM   1429 O  OD1 . ASP   A 1  179 ? 5.098   -5.611  -22.176 1    19.566  ? 215  ASP   A OD1 1 
ATOM   1430 O  OD2 . ASP   A 1  179 ? 6.9     -6.576  -22.992 1    21.279  ? 215  ASP   A OD2 1 
ATOM   1431 N  N   . ALA   A 1  180 ? 4.899   -4.712  -19.02  1    15.239  ? 216  ALA   A N   1 
ATOM   1432 C  CA  . ALA   A 1  180 ? 3.567   -4.249  -18.651 1    14.734  ? 216  ALA   A CA  1 
ATOM   1433 C  C   . ALA   A 1  180 ? 2.511   -4.423  -19.754 1    16.856  ? 216  ALA   A C   1 
ATOM   1434 O  O   . ALA   A 1  180 ? 1.335   -4.682  -19.459 1    16.784  ? 216  ALA   A O   1 
ATOM   1435 C  CB  . ALA   A 1  180 ? 3.625   -2.72   -18.238 1    16.425  ? 216  ALA   A CB  1 
ATOM   1436 N  N   . GLY   A 1  181 ? 2.916   -4.269  -21.019 1    19.47   ? 217  GLY   A N   1 
ATOM   1437 C  CA  . GLY   A 1  181 ? 2.013   -4.441  -22.166 1    18.798  ? 217  GLY   A CA  1 
ATOM   1438 C  C   . GLY   A 1  181 ? 1.509   -5.9    -22.24  1    18.537  ? 217  GLY   A C   1 
ATOM   1439 O  O   . GLY   A 1  181 ? 0.35    -6.157  -22.538 1    20.324  ? 217  GLY   A O   1 
ATOM   1440 N  N   . ASP   A 1  182 ? 2.405   -6.871  -22.048 1    16.002  ? 218  ASP   A N   1 
ATOM   1441 C  CA  . ASP   A 1  182 ? 1.972   -8.288  -21.993 1    18.561  ? 218  ASP   A CA  1 
ATOM   1442 C  C   . ASP   A 1  182 ? 0.921   -8.471  -20.887 1    19.477  ? 218  ASP   A C   1 
ATOM   1443 O  O   . ASP   A 1  182 ? -0.139  -9.089  -21.064 1    21.259  ? 218  ASP   A O   1 
ATOM   1444 C  CB  . ASP   A 1  182 ? 3.239   -9.101  -21.706 1    17.592  ? 218  ASP   A CB  1 
ATOM   1445 C  CG  . ASP   A 1  182 ? 3.063   -10.614 -21.607 1    24.716  ? 218  ASP   A CG  1 
ATOM   1446 O  OD1 . ASP   A 1  182 ? 2.19    -11.126 -22.38  1    23.729  ? 218  ASP   A OD1 1 
ATOM   1447 O  OD2 . ASP   A 1  182 ? 3.839   -11.268 -20.797 1    22.061  ? 218  ASP   A OD2 1 
ATOM   1448 N  N   A SER   A 1  183 ? 1.234   -7.906  -19.71  0.57 20.404  ? 219  SER   A N   1 
ATOM   1449 N  N   B SER   A 1  183 ? 1.217   -7.896  -19.707 0.43 20.374  ? 219  SER   A N   1 
ATOM   1450 C  CA  A SER   A 1  183 ? 0.291   -7.918  -18.607 0.57 19.148  ? 219  SER   A CA  1 
ATOM   1451 C  CA  B SER   A 1  183 ? 0.268   -7.944  -18.604 0.43 19.378  ? 219  SER   A CA  1 
ATOM   1452 C  C   A SER   A 1  183 ? -1.083  -7.354  -19.019 0.57 20.552  ? 219  SER   A C   1 
ATOM   1453 C  C   B SER   A 1  183 ? -1.094  -7.355  -19.011 0.43 20.408  ? 219  SER   A C   1 
ATOM   1454 O  O   A SER   A 1  183 ? -2.122  -7.937  -18.708 0.57 18.998  ? 219  SER   A O   1 
ATOM   1455 O  O   B SER   A 1  183 ? -2.129  -7.958  -18.731 0.43 19.297  ? 219  SER   A O   1 
ATOM   1456 C  CB  A SER   A 1  183 ? 0.881   -7.18   -17.439 0.57 18.167  ? 219  SER   A CB  1 
ATOM   1457 C  CB  B SER   A 1  183 ? 0.847   -7.326  -17.342 0.43 18.74   ? 219  SER   A CB  1 
ATOM   1458 O  OG  A SER   A 1  183 ? -0.091  -7.221  -16.418 0.57 17.87   ? 219  SER   A OG  1 
ATOM   1459 O  OG  B SER   A 1  183 ? 0.79    -5.91   -17.363 0.43 18.549  ? 219  SER   A OG  1 
ATOM   1460 N  N   . TRP   A 1  184 ? -1.113  -6.186  -19.679 1    18.441  ? 220  TRP   A N   1 
ATOM   1461 C  CA  . TRP   A 1  184 ? -2.385  -5.581  -20.066 1    20.602  ? 220  TRP   A CA  1 
ATOM   1462 C  C   . TRP   A 1  184 ? -3.175  -6.457  -21.056 1    20.694  ? 220  TRP   A C   1 
ATOM   1463 O  O   . TRP   A 1  184 ? -4.384  -6.635  -20.882 1    17.723  ? 220  TRP   A O   1 
ATOM   1464 C  CB  . TRP   A 1  184 ? -2.147  -4.161  -20.603 1    15.953  ? 220  TRP   A CB  1 
ATOM   1465 C  CG  . TRP   A 1  184 ? -1.64   -3.192  -19.571 1    14.834  ? 220  TRP   A CG  1 
ATOM   1466 C  CD1 . TRP   A 1  184 ? -1.447  -3.31   -18.222 1    14.942  ? 220  TRP   A CD1 1 
ATOM   1467 C  CD2 . TRP   A 1  184 ? -1.415  -1.81   -19.865 1    15.356  ? 220  TRP   A CD2 1 
ATOM   1468 N  NE1 . TRP   A 1  184 ? -1.105  -2.074  -17.687 1    16.216  ? 220  TRP   A NE1 1 
ATOM   1469 C  CE2 . TRP   A 1  184 ? -1.138  -1.152  -18.66  1    15.956  ? 220  TRP   A CE2 1 
ATOM   1470 C  CE3 . TRP   A 1  184 ? -1.539  -1.068  -21.045 1    15.826  ? 220  TRP   A CE3 1 
ATOM   1471 C  CZ2 . TRP   A 1  184 ? -0.882  0.216   -18.593 1    21.606  ? 220  TRP   A CZ2 1 
ATOM   1472 C  CZ3 . TRP   A 1  184 ? -1.363  0.292   -20.95  1    19.002  ? 220  TRP   A CZ3 1 
ATOM   1473 C  CH2 . TRP   A 1  184 ? -1.045  0.918   -19.754 1    17.36   ? 220  TRP   A CH2 1 
ATOM   1474 N  N   . ARG   A 1  185 ? -2.507  -6.981  -22.1   1    19.463  ? 221  ARG   A N   1 
ATOM   1475 C  CA  . ARG   A 1  185 ? -3.087  -7.847  -23.12  1    19.758  ? 221  ARG   A CA  1 
ATOM   1476 C  C   . ARG   A 1  185 ? -3.681  -9.103  -22.45  1    22.053  ? 221  ARG   A C   1 
ATOM   1477 O  O   . ARG   A 1  185 ? -4.743  -9.589  -22.897 1    16.529  ? 221  ARG   A O   1 
ATOM   1478 C  CB  . ARG   A 1  185 ? -2.065  -8.131  -24.252 1    18.24   ? 221  ARG   A CB  1 
ATOM   1479 C  CG  . ARG   A 1  185 ? -1.589  -6.892  -25.025 1    19.867  ? 221  ARG   A CG  1 
ATOM   1480 C  CD  . ARG   A 1  185 ? -0.809  -7.391  -26.277 1    20.222  ? 221  ARG   A CD  1 
ATOM   1481 N  NE  . ARG   A 1  185 ? 0.402   -8.128  -25.898 1    18.916  ? 221  ARG   A NE  1 
ATOM   1482 C  CZ  . ARG   A 1  185 ? 1.561   -7.569  -25.59  1    19.264  ? 221  ARG   A CZ  1 
ATOM   1483 N  NH1 . ARG   A 1  185 ? 2.623   -8.34   -25.331 1    19.675  ? 221  ARG   A NH1 1 
ATOM   1484 N  NH2 . ARG   A 1  185 ? 1.705   -6.241  -25.633 1    19.352  ? 221  ARG   A NH2 1 
ATOM   1485 N  N   A SER   A 1  186 ? -3.023  -9.593  -21.367 0.5  19.96   ? 222  SER   A N   1 
ATOM   1486 N  N   B SER   A 1  186 ? -3.039  -9.618  -21.374 0.5  21.212  ? 222  SER   A N   1 
ATOM   1487 C  CA  A SER   A 1  186 ? -3.453  -10.807 -20.648 0.5  20.356  ? 222  SER   A CA  1 
ATOM   1488 C  CA  B SER   A 1  186 ? -3.512  -10.859 -20.734 0.5  21.766  ? 222  SER   A CA  1 
ATOM   1489 C  C   A SER   A 1  186 ? -4.883  -10.693 -20.134 0.5  17.54   ? 222  SER   A C   1 
ATOM   1490 C  C   B SER   A 1  186 ? -4.863  -10.693 -20.037 0.5  18.016  ? 222  SER   A C   1 
ATOM   1491 O  O   A SER   A 1  186 ? -5.604  -11.674 -20.072 0.5  18.216  ? 222  SER   A O   1 
ATOM   1492 O  O   B SER   A 1  186 ? -5.57   -11.642 -19.782 0.5  19.168  ? 222  SER   A O   1 
ATOM   1493 C  CB  A SER   A 1  186 ? -2.573  -11.147 -19.469 0.5  18.433  ? 222  SER   A CB  1 
ATOM   1494 C  CB  B SER   A 1  186 ? -2.497  -11.483 -19.793 0.5  20.968  ? 222  SER   A CB  1 
ATOM   1495 O  OG  A SER   A 1  186 ? -2.845  -10.272 -18.388 0.5  15.902  ? 222  SER   A OG  1 
ATOM   1496 O  OG  B SER   A 1  186 ? -1.283  -11.751 -20.484 0.5  22.78   ? 222  SER   A OG  1 
ATOM   1497 N  N   . MET   A 1  187 ? -5.323  -9.467  -19.876 1    19.708  ? 223  MET   A N   1 
ATOM   1498 C  CA  . MET   A 1  187 ? -6.629  -9.227  -19.287 1    22.665  ? 223  MET   A CA  1 
ATOM   1499 C  C   . MET   A 1  187 ? -7.767  -9.693  -20.225 1    21.578  ? 223  MET   A C   1 
ATOM   1500 O  O   . MET   A 1  187 ? -8.867  -9.861  -19.736 1    24.276  ? 223  MET   A O   1 
ATOM   1501 C  CB  . MET   A 1  187 ? -6.778  -7.735  -18.884 1    22.438  ? 223  MET   A CB  1 
ATOM   1502 C  CG  . MET   A 1  187 ? -5.717  -7.232  -17.882 1    33.413  ? 223  MET   A CG  1 
ATOM   1503 S  SD  . MET   A 1  187 ? -5.971  -5.462  -17.599 1    47.339  ? 223  MET   A SD  1 
ATOM   1504 C  CE  . MET   A 1  187 ? -7.596  -5.731  -16.869 1    43.712  ? 223  MET   A CE  1 
ATOM   1505 N  N   . TYR   A 1  188 ? -7.523  -9.886  -21.542 1    18.13   ? 224  TYR   A N   1 
ATOM   1506 C  CA  . TYR   A 1  188 ? -8.524  -10.357 -22.493 1    16.254  ? 224  TYR   A CA  1 
ATOM   1507 C  C   . TYR   A 1  188 ? -8.529  -11.877 -22.495 1    17.943  ? 224  TYR   A C   1 
ATOM   1508 O  O   . TYR   A 1  188 ? -9.433  -12.43  -23.073 1    20.126  ? 224  TYR   A O   1 
ATOM   1509 C  CB  . TYR   A 1  188 ? -8.195  -9.843  -23.908 1    18.523  ? 224  TYR   A CB  1 
ATOM   1510 C  CG  . TYR   A 1  188 ? -8.446  -8.347  -23.883 1    19.519  ? 224  TYR   A CG  1 
ATOM   1511 C  CD1 . TYR   A 1  188 ? -7.465  -7.447  -23.504 1    19.715  ? 224  TYR   A CD1 1 
ATOM   1512 C  CD2 . TYR   A 1  188 ? -9.715  -7.852  -24.221 1    18.478  ? 224  TYR   A CD2 1 
ATOM   1513 C  CE1 . TYR   A 1  188 ? -7.766  -6.082  -23.402 1    18.61   ? 224  TYR   A CE1 1 
ATOM   1514 C  CE2 . TYR   A 1  188 ? -10.012 -6.494  -24.161 1    17.913  ? 224  TYR   A CE2 1 
ATOM   1515 C  CZ  . TYR   A 1  188 ? -9.022  -5.612  -23.763 1    20.556  ? 224  TYR   A CZ  1 
ATOM   1516 O  OH  . TYR   A 1  188 ? -9.368  -4.29   -23.603 1    19.753  ? 224  TYR   A OH  1 
ATOM   1517 N  N   . GLU   A 1  189 ? -7.492  -12.545 -21.924 1    20.121  ? 225  GLU   A N   1 
ATOM   1518 C  CA  . GLU   A 1  189 ? -7.358  -14.016 -21.945 1    19.88   ? 225  GLU   A CA  1 
ATOM   1519 C  C   . GLU   A 1  189 ? -7.558  -14.575 -23.362 1    24.313  ? 225  GLU   A C   1 
ATOM   1520 O  O   . GLU   A 1  189 ? -8.223  -15.578 -23.594 1    21.253  ? 225  GLU   A O   1 
ATOM   1521 C  CB  . GLU   A 1  189 ? -8.44   -14.627 -21.06  1    23.285  ? 225  GLU   A CB  1 
ATOM   1522 C  CG  . GLU   A 1  189 ? -8.496  -14.018 -19.666 1    25.944  ? 225  GLU   A CG  1 
ATOM   1523 C  CD  . GLU   A 1  189 ? -9.468  -14.9   -18.859 1    38.087  ? 225  GLU   A CD  1 
ATOM   1524 O  OE1 . GLU   A 1  189 ? -10.694 -14.979 -19.019 1    33.226  ? 225  GLU   A OE1 1 
ATOM   1525 O  OE2 . GLU   A 1  189 ? -8.945  -15.598 -18.001 1    38.606  ? 225  GLU   A OE2 1 
ATOM   1526 N  N   . THR   A 1  190 ? -6.988  -13.88  -24.349 1    22.503  ? 226  THR   A N   1 
ATOM   1527 C  CA  . THR   A 1  190 ? -7.185  -14.187 -25.765 1    20.142  ? 226  THR   A CA  1 
ATOM   1528 C  C   . THR   A 1  190 ? -5.787  -14.19  -26.398 1    22.145  ? 226  THR   A C   1 
ATOM   1529 O  O   . THR   A 1  190 ? -5.257  -13.131 -26.738 1    21.27   ? 226  THR   A O   1 
ATOM   1530 C  CB  . THR   A 1  190 ? -8.08   -13.127 -26.422 1    19.006  ? 226  THR   A CB  1 
ATOM   1531 O  OG1 . THR   A 1  190 ? -9.268  -13.324 -25.668 1    22.908  ? 226  THR   A OG1 1 
ATOM   1532 C  CG2 . THR   A 1  190 ? -8.305  -13.413 -27.899 1    19.778  ? 226  THR   A CG2 1 
ATOM   1533 N  N   . PRO   A 1  191 ? -5.075  -15.344 -26.472 1    26.197  ? 227  PRO   A N   1 
ATOM   1534 C  CA  . PRO   A 1  191 ? -3.718  -15.358 -27.052 1    26.425  ? 227  PRO   A CA  1 
ATOM   1535 C  C   . PRO   A 1  191 ? -3.581  -14.849 -28.498 1    23.802  ? 227  PRO   A C   1 
ATOM   1536 O  O   . PRO   A 1  191 ? -2.521  -14.242 -28.831 1    22.17   ? 227  PRO   A O   1 
ATOM   1537 C  CB  . PRO   A 1  191 ? -3.276  -16.834 -26.847 1    31.392  ? 227  PRO   A CB  1 
ATOM   1538 C  CG  . PRO   A 1  191 ? -4.242  -17.349 -25.757 1    31.146  ? 227  PRO   A CG  1 
ATOM   1539 C  CD  . PRO   A 1  191 ? -5.569  -16.676 -26.054 1    22.166  ? 227  PRO   A CD  1 
ATOM   1540 N  N   . SER   A 1  192 ? -4.718  -14.882 -29.265 1    21.742  ? 228  SER   A N   1 
ATOM   1541 C  CA  . SER   A 1  192 ? -4.716  -14.343 -30.636 1    22.78   ? 228  SER   A CA  1 
ATOM   1542 C  C   . SER   A 1  192 ? -5.173  -12.885 -30.688 1    21.623  ? 228  SER   A C   1 
ATOM   1543 O  O   . SER   A 1  192 ? -5.328  -12.338 -31.787 1    21.257  ? 228  SER   A O   1 
ATOM   1544 C  CB  . SER   A 1  192 ? -5.604  -15.17  -31.56  1    22.167  ? 228  SER   A CB  1 
ATOM   1545 O  OG  . SER   A 1  192 ? -6.916  -15.165 -30.978 1    24.454  ? 228  SER   A OG  1 
ATOM   1546 N  N   . LEU   A 1  193 ? -5.253  -12.224 -29.53  1    19.98   ? 229  LEU   A N   1 
ATOM   1547 C  CA  . LEU   A 1  193 ? -5.645  -10.803 -29.471 1    18.217  ? 229  LEU   A CA  1 
ATOM   1548 C  C   . LEU   A 1  193 ? -5.014  -9.913  -30.571 1    21.164  ? 229  LEU   A C   1 
ATOM   1549 O  O   . LEU   A 1  193 ? -5.717  -9.144  -31.26  1    19.741  ? 229  LEU   A O   1 
ATOM   1550 C  CB  . LEU   A 1  193 ? -5.383  -10.225 -28.072 1    15.534  ? 229  LEU   A CB  1 
ATOM   1551 C  CG  . LEU   A 1  193 ? -6.046  -8.832  -27.901 1    17.247  ? 229  LEU   A CG  1 
ATOM   1552 C  CD1 . LEU   A 1  193 ? -7.582  -8.94   -27.815 1    16.731  ? 229  LEU   A CD1 1 
ATOM   1553 C  CD2 . LEU   A 1  193 ? -5.517  -8.222  -26.586 1    17.118  ? 229  LEU   A CD2 1 
ATOM   1554 N  N   . GLU   A 1  194 ? -3.662  -9.856  -30.662 1    16.388  ? 230  GLU   A N   1 
ATOM   1555 C  CA  . GLU   A 1  194 ? -3.06   -8.869  -31.541 1    19.954  ? 230  GLU   A CA  1 
ATOM   1556 C  C   . GLU   A 1  194 ? -3.559  -9.137  -32.949 1    22.629  ? 230  GLU   A C   1 
ATOM   1557 O  O   . GLU   A 1  194 ? -3.814  -8.224  -33.729 1    20.315  ? 230  GLU   A O   1 
ATOM   1558 C  CB  . GLU   A 1  194 ? -1.516  -8.852  -31.475 1    19.662  ? 230  GLU   A CB  1 
ATOM   1559 C  CG  . GLU   A 1  194 ? -1.04   -8.45   -30.075 1    22.375  ? 230  GLU   A CG  1 
ATOM   1560 C  CD  . GLU   A 1  194 ? 0.431   -8.045  -29.969 1    26.485  ? 230  GLU   A CD  1 
ATOM   1561 O  OE1 . GLU   A 1  194 ? 1.059   -8.06   -31.008 1    25.424  ? 230  GLU   A OE1 1 
ATOM   1562 O  OE2 . GLU   A 1  194 ? 0.968   -7.689  -28.898 1    27.278  ? 230  GLU   A OE2 1 
ATOM   1563 N  N   . GLN   A 1  195 ? -3.561  -10.399 -33.355 1    19.446  ? 231  GLN   A N   1 
ATOM   1564 C  CA  . GLN   A 1  195 ? -3.927  -10.652 -34.753 1    22.554  ? 231  GLN   A CA  1 
ATOM   1565 C  C   . GLN   A 1  195 ? -5.418  -10.418 -34.956 1    20.802  ? 231  GLN   A C   1 
ATOM   1566 O  O   . GLN   A 1  195 ? -5.807  -9.902  -36.014 1    22.457  ? 231  GLN   A O   1 
ATOM   1567 C  CB  . GLN   A 1  195 ? -3.622  -12.102 -35.164 1    28.582  ? 231  GLN   A CB  1 
ATOM   1568 C  CG  . GLN   A 1  195 ? -2.136  -12.436 -35.037 1    40.714  ? 231  GLN   A CG  1 
ATOM   1569 C  CD  . GLN   A 1  195 ? -1.915  -13.938 -35.029 1    50.956  ? 231  GLN   A CD  1 
ATOM   1570 O  OE1 . GLN   A 1  195 ? -1.359  -14.451 -36     1    58.67   ? 231  GLN   A OE1 1 
ATOM   1571 N  NE2 . GLN   A 1  195 ? -2.407  -14.66  -34.006 1    49.295  ? 231  GLN   A NE2 1 
ATOM   1572 N  N   . ASP   A 1  196 ? -6.246  -10.827 -33.978 1    19.186  ? 232  ASP   A N   1 
ATOM   1573 C  CA  . ASP   A 1  196 ? -7.689  -10.593 -34.048 1    20.667  ? 232  ASP   A CA  1 
ATOM   1574 C  C   . ASP   A 1  196 ? -7.977  -9.098  -34.236 1    24.038  ? 232  ASP   A C   1 
ATOM   1575 O  O   . ASP   A 1  196 ? -8.811  -8.685  -35.053 1    26.478  ? 232  ASP   A O   1 
ATOM   1576 C  CB  . ASP   A 1  196 ? -8.429  -11.002 -32.775 1    18.285  ? 232  ASP   A CB  1 
ATOM   1577 C  CG  . ASP   A 1  196 ? -8.403  -12.513 -32.574 1    30.51   ? 232  ASP   A CG  1 
ATOM   1578 O  OD1 . ASP   A 1  196 ? -8.193  -13.206 -33.607 1    27.472  ? 232  ASP   A OD1 1 
ATOM   1579 O  OD2 . ASP   A 1  196 ? -8.516  -12.987 -31.429 1    31.148  ? 232  ASP   A OD2 1 
ATOM   1580 N  N   . LEU   A 1  197 ? -7.279  -8.267  -33.469 1    22.691  ? 233  LEU   A N   1 
ATOM   1581 C  CA  . LEU   A 1  197 ? -7.601  -6.852  -33.569 1    19.507  ? 233  LEU   A CA  1 
ATOM   1582 C  C   . LEU   A 1  197 ? -7.057  -6.283  -34.878 1    22.78   ? 233  LEU   A C   1 
ATOM   1583 O  O   . LEU   A 1  197 ? -7.689  -5.364  -35.419 1    20.862  ? 233  LEU   A O   1 
ATOM   1584 C  CB  . LEU   A 1  197 ? -6.94   -6.186  -32.371 1    19.18   ? 233  LEU   A CB  1 
ATOM   1585 C  CG  . LEU   A 1  197 ? -7.55   -6.605  -31.016 1    21.408  ? 233  LEU   A CG  1 
ATOM   1586 C  CD1 . LEU   A 1  197 ? -7.122  -5.664  -29.85  1    20.804  ? 233  LEU   A CD1 1 
ATOM   1587 C  CD2 . LEU   A 1  197 ? -9.105  -6.774  -30.977 1    19.8    ? 233  LEU   A CD2 1 
ATOM   1588 N  N   . GLU   A 1  198 ? -5.841  -6.706  -35.299 1    23.471  ? 234  GLU   A N   1 
ATOM   1589 C  CA  . GLU   A 1  198 ? -5.34   -6.405  -36.653 1    25.655  ? 234  GLU   A CA  1 
ATOM   1590 C  C   . GLU   A 1  198 ? -6.421  -6.66   -37.743 1    26.346  ? 234  GLU   A C   1 
ATOM   1591 O  O   . GLU   A 1  198 ? -6.706  -5.801  -38.606 1    21.122  ? 234  GLU   A O   1 
ATOM   1592 C  CB  . GLU   A 1  198 ? -3.99   -7.091  -36.929 1    29.21   ? 234  GLU   A CB  1 
ATOM   1593 C  CG  . GLU   A 1  198 ? -3.3    -6.716  -38.249 1    37.418  ? 234  GLU   A CG  1 
ATOM   1594 C  CD  . GLU   A 1  198 ? -3.1    -5.228  -38.521 1    63.609  ? 234  GLU   A CD  1 
ATOM   1595 O  OE1 . GLU   A 1  198 ? -2.456  -4.472  -37.743 1    71.869  ? 234  GLU   A OE1 1 
ATOM   1596 O  OE2 . GLU   A 1  198 ? -3.619  -4.8    -39.577 1    74.502  ? 234  GLU   A OE2 1 
ATOM   1597 N  N   . ARG   A 1  199 ? -7.095  -7.826  -37.701 1    21.085  ? 235  ARG   A N   1 
ATOM   1598 C  CA  . ARG   A 1  199 ? -7.928  -8.104  -38.852 1    24.258  ? 235  ARG   A CA  1 
ATOM   1599 C  C   . ARG   A 1  199 ? -9.149  -7.194  -38.744 1    24.81   ? 235  ARG   A C   1 
ATOM   1600 O  O   . ARG   A 1  199 ? -9.682  -6.815  -39.784 1    20.33   ? 235  ARG   A O   1 
ATOM   1601 C  CB  . ARG   A 1  199 ? -8.625  -9.467  -38.77  1    28.826  ? 235  ARG   A CB  1 
ATOM   1602 C  CG  . ARG   A 1  199 ? -7.746  -10.675 -39.016 1    47.372  ? 235  ARG   A CG  1 
ATOM   1603 C  CD  . ARG   A 1  199 ? -8.485  -11.763 -38.23  1    71.025  ? 235  ARG   A CD  1 
ATOM   1604 N  NE  . ARG   A 1  199 ? -7.592  -12.78  -37.653 1    84.468  ? 235  ARG   A NE  1 
ATOM   1605 C  CZ  . ARG   A 1  199 ? -7.834  -14.085 -37.668 1    110.14  ? 235  ARG   A CZ  1 
ATOM   1606 N  NH1 . ARG   A 1  199 ? -9.051  -14.537 -37.943 1    126.685 ? 235  ARG   A NH1 1 
ATOM   1607 N  NH2 . ARG   A 1  199 ? -6.861  -14.933 -37.369 1    115.48  ? 235  ARG   A NH2 1 
ATOM   1608 N  N   . LEU   A 1  200 ? -9.689  -7.031  -37.51  1    21.501  ? 236  LEU   A N   1 
ATOM   1609 C  CA  . LEU   A 1  200 ? -10.79  -6.119  -37.265 1    22.789  ? 236  LEU   A CA  1 
ATOM   1610 C  C   . LEU   A 1  200 ? -10.475 -4.707  -37.805 1    25.717  ? 236  LEU   A C   1 
ATOM   1611 O  O   . LEU   A 1  200 ? -11.345 -4.062  -38.417 1    24.271  ? 236  LEU   A O   1 
ATOM   1612 C  CB  . LEU   A 1  200 ? -11.167 -6.119  -35.786 1    23.218  ? 236  LEU   A CB  1 
ATOM   1613 C  CG  . LEU   A 1  200 ? -11.827 -7.399  -35.265 1    26.01   ? 236  LEU   A CG  1 
ATOM   1614 C  CD1 . LEU   A 1  200 ? -11.844 -7.299  -33.719 1    21.2    ? 236  LEU   A CD1 1 
ATOM   1615 C  CD2 . LEU   A 1  200 ? -13.252 -7.587  -35.812 1    25.51   ? 236  LEU   A CD2 1 
ATOM   1616 N  N   . PHE   A 1  201 ? -9.283  -4.157  -37.487 1    17.335  ? 237  PHE   A N   1 
ATOM   1617 C  CA  . PHE   A 1  201 ? -8.96   -2.816  -37.963 1    18.888  ? 237  PHE   A CA  1 
ATOM   1618 C  C   . PHE   A 1  201 ? -8.922  -2.861  -39.502 1    21.213  ? 237  PHE   A C   1 
ATOM   1619 O  O   . PHE   A 1  201 ? -9.376  -1.949  -40.185 1    20.611  ? 237  PHE   A O   1 
ATOM   1620 C  CB  . PHE   A 1  201 ? -7.529  -2.623  -37.401 1    18.132  ? 237  PHE   A CB  1 
ATOM   1621 C  CG  . PHE   A 1  201 ? -6.983  -1.316  -37.939 1    22.098  ? 237  PHE   A CG  1 
ATOM   1622 C  CD1 . PHE   A 1  201 ? -7.505  -0.109  -37.51  1    25.168  ? 237  PHE   A CD1 1 
ATOM   1623 C  CD2 . PHE   A 1  201 ? -6.053  -1.297  -38.978 1    25.762  ? 237  PHE   A CD2 1 
ATOM   1624 C  CE1 . PHE   A 1  201 ? -7.017  1.084   -38     1    26.181  ? 237  PHE   A CE1 1 
ATOM   1625 C  CE2 . PHE   A 1  201 ? -5.59   -0.081  -39.496 1    32.815  ? 237  PHE   A CE2 1 
ATOM   1626 C  CZ  . PHE   A 1  201 ? -6.056  1.105   -38.984 1    29.265  ? 237  PHE   A CZ  1 
ATOM   1627 N  N   . GLN   A 1  202 ? -8.409  -3.962  -40.089 1    23.302  ? 238  GLN   A N   1 
ATOM   1628 C  CA  . GLN   A 1  202 ? -8.289  -3.985  -41.555 1    24.266  ? 238  GLN   A CA  1 
ATOM   1629 C  C   . GLN   A 1  202 ? -9.666  -4.022  -42.203 1    21.02   ? 238  GLN   A C   1 
ATOM   1630 O  O   . GLN   A 1  202 ? -9.897  -3.329  -43.21  1    20.103  ? 238  GLN   A O   1 
ATOM   1631 C  CB  . GLN   A 1  202 ? -7.485  -5.164  -42.116 1    24.362  ? 238  GLN   A CB  1 
ATOM   1632 C  CG  . GLN   A 1  202 ? -5.993  -5.093  -41.784 1    32.789  ? 238  GLN   A CG  1 
ATOM   1633 C  CD  . GLN   A 1  202 ? -5.333  -3.941  -42.514 1    39.695  ? 238  GLN   A CD  1 
ATOM   1634 O  OE1 . GLN   A 1  202 ? -5.772  -3.59   -43.615 1    37.947  ? 238  GLN   A OE1 1 
ATOM   1635 N  NE2 . GLN   A 1  202 ? -4.326  -3.307  -41.926 1    41.116  ? 238  GLN   A NE2 1 
ATOM   1636 N  N   . GLU   A 1  203 ? -10.634 -4.639  -41.514 1    20.956  ? 239  GLU   A N   1 
ATOM   1637 C  CA  . GLU   A 1  203 ? -11.973 -4.625  -42.07  1    23.299  ? 239  GLU   A CA  1 
ATOM   1638 C  C   . GLU   A 1  203 ? -12.605 -3.24   -42.102 1    24.703  ? 239  GLU   A C   1 
ATOM   1639 O  O   . GLU   A 1  203 ? -13.495 -3.058  -42.926 1    21.625  ? 239  GLU   A O   1 
ATOM   1640 C  CB  . GLU   A 1  203 ? -12.913 -5.619  -41.417 1    24.257  ? 239  GLU   A CB  1 
ATOM   1641 C  CG  . GLU   A 1  203 ? -12.317 -7.023  -41.655 1    29.531  ? 239  GLU   A CG  1 
ATOM   1642 C  CD  . GLU   A 1  203 ? -13.426 -7.935  -41.211 1    49.345  ? 239  GLU   A CD  1 
ATOM   1643 O  OE1 . GLU   A 1  203 ? -14.451 -7.928  -41.948 1    54.852  ? 239  GLU   A OE1 1 
ATOM   1644 O  OE2 . GLU   A 1  203 ? -13.331 -8.511  -40.1   1    50.535  ? 239  GLU   A OE2 1 
ATOM   1645 N  N   . LEU   A 1  204 ? -12.214 -2.314  -41.2   1    20.227  ? 240  LEU   A N   1 
ATOM   1646 C  CA  . LEU   A 1  204 ? -12.824 -1.001  -41.181 1    23.472  ? 240  LEU   A CA  1 
ATOM   1647 C  C   . LEU   A 1  204 ? -12.053 -0.026  -42.074 1    22.946  ? 240  LEU   A C   1 
ATOM   1648 O  O   . LEU   A 1  204 ? -12.337 1.171   -42.06  1    23.632  ? 240  LEU   A O   1 
ATOM   1649 C  CB  . LEU   A 1  204 ? -12.794 -0.463  -39.76  1    24.774  ? 240  LEU   A CB  1 
ATOM   1650 C  CG  . LEU   A 1  204 ? -14.059 -0.616  -38.911 1    27.286  ? 240  LEU   A CG  1 
ATOM   1651 C  CD1 . LEU   A 1  204 ? -15.272 0.21    -39.388 1    31.801  ? 240  LEU   A CD1 1 
ATOM   1652 C  CD2 . LEU   A 1  204 ? -14.495 -1.962  -38.59  1    25.93   ? 240  LEU   A CD2 1 
ATOM   1653 N  N   . GLN   A 1  205 ? -11.059 -0.484  -42.817 1    22.437  ? 241  GLN   A N   1 
ATOM   1654 C  CA  . GLN   A 1  205 ? -10.245 0.407   -43.641 1    22.985  ? 241  GLN   A CA  1 
ATOM   1655 C  C   . GLN   A 1  205 ? -11.032 1.079   -44.773 1    24.919  ? 241  GLN   A C   1 
ATOM   1656 O  O   . GLN   A 1  205 ? -10.889 2.3     -44.973 1    27.147  ? 241  GLN   A O   1 
ATOM   1657 C  CB  . GLN   A 1  205 ? -9.06   -0.399  -44.14  1    29.944  ? 241  GLN   A CB  1 
ATOM   1658 C  CG  . GLN   A 1  205 ? -7.94   -0.483  -43.097 1    32.85   ? 241  GLN   A CG  1 
ATOM   1659 C  CD  . GLN   A 1  205 ? -7.191  0.831   -43.068 1    32.683  ? 241  GLN   A CD  1 
ATOM   1660 O  OE1 . GLN   A 1  205 ? -7.512  1.696   -42.267 1    35.195  ? 241  GLN   A OE1 1 
ATOM   1661 N  NE2 . GLN   A 1  205 ? -6.329  1.062   -44.047 1    37.696  ? 241  GLN   A NE2 1 
ATOM   1662 N  N   . PRO   A 1  206 ? -11.859 0.348   -45.565 1    29.007  ? 242  PRO   A N   1 
ATOM   1663 C  CA  . PRO   A 1  206 ? -12.741 0.97    -46.544 1    26.159  ? 242  PRO   A CA  1 
ATOM   1664 C  C   . PRO   A 1  206 ? -13.468 2.151   -45.934 1    24.655  ? 242  PRO   A C   1 
ATOM   1665 O  O   . PRO   A 1  206 ? -13.449 3.266   -46.507 1    26.385  ? 242  PRO   A O   1 
ATOM   1666 C  CB  . PRO   A 1  206 ? -13.678 -0.227  -46.912 1    32.247  ? 242  PRO   A CB  1 
ATOM   1667 C  CG  . PRO   A 1  206 ? -12.651 -1.367  -46.989 1    26.624  ? 242  PRO   A CG  1 
ATOM   1668 C  CD  . PRO   A 1  206 ? -11.85  -1.129  -45.716 1    29.056  ? 242  PRO   A CD  1 
ATOM   1669 N  N   . LEU   A 1  207 ? -14.09  1.907   -44.775 1    24.927  ? 243  LEU   A N   1 
ATOM   1670 C  CA  . LEU   A 1  207 ? -14.934 2.982   -44.296 1    24.355  ? 243  LEU   A CA  1 
ATOM   1671 C  C   . LEU   A 1  207 ? -14.073 4.173   -43.854 1    22.837  ? 243  LEU   A C   1 
ATOM   1672 O  O   . LEU   A 1  207 ? -14.398 5.345   -44.176 1    20.155  ? 243  LEU   A O   1 
ATOM   1673 C  CB  . LEU   A 1  207 ? -15.78  2.475   -43.138 1    26.245  ? 243  LEU   A CB  1 
ATOM   1674 C  CG  . LEU   A 1  207 ? -17.258 2.28    -43.385 1    35.612  ? 243  LEU   A CG  1 
ATOM   1675 C  CD1 . LEU   A 1  207 ? -17.711 1.433   -42.254 1    31.982  ? 243  LEU   A CD1 1 
ATOM   1676 C  CD2 . LEU   A 1  207 ? -17.929 3.654   -43.377 1    37.674  ? 243  LEU   A CD2 1 
ATOM   1677 N  N   . TYR   A 1  208 ? -13.012 3.86    -43.056 1    18.847  ? 244  TYR   A N   1 
ATOM   1678 C  CA  . TYR   A 1  208 ? -12.161 4.92    -42.523 1    17.996  ? 244  TYR   A CA  1 
ATOM   1679 C  C   . TYR   A 1  208 ? -11.483 5.682   -43.68  1    17.306  ? 244  TYR   A C   1 
ATOM   1680 O  O   . TYR   A 1  208 ? -11.483 6.917   -43.735 1    17.183  ? 244  TYR   A O   1 
ATOM   1681 C  CB  . TYR   A 1  208 ? -11.117 4.409   -41.536 1    14.802  ? 244  TYR   A CB  1 
ATOM   1682 C  CG  . TYR   A 1  208 ? -10.31  5.6     -41.033 1    17.476  ? 244  TYR   A CG  1 
ATOM   1683 C  CD1 . TYR   A 1  208 ? -10.944 6.559   -40.225 1    18.22   ? 244  TYR   A CD1 1 
ATOM   1684 C  CD2 . TYR   A 1  208 ? -8.987  5.822   -41.416 1    20.573  ? 244  TYR   A CD2 1 
ATOM   1685 C  CE1 . TYR   A 1  208 ? -10.29  7.702   -39.804 1    18.801  ? 244  TYR   A CE1 1 
ATOM   1686 C  CE2 . TYR   A 1  208 ? -8.304  6.964   -40.999 1    23.381  ? 244  TYR   A CE2 1 
ATOM   1687 C  CZ  . TYR   A 1  208 ? -8.949  7.874   -40.168 1    19.093  ? 244  TYR   A CZ  1 
ATOM   1688 O  OH  . TYR   A 1  208 ? -8.314  8.968   -39.734 1    20.409  ? 244  TYR   A OH  1 
ATOM   1689 N  N   . LEU   A 1  209 ? -10.91  4.975   -44.669 1    17.449  ? 245  LEU   A N   1 
ATOM   1690 C  CA  . LEU   A 1  209 ? -10.209 5.765   -45.697 1    20.297  ? 245  LEU   A CA  1 
ATOM   1691 C  C   . LEU   A 1  209 ? -11.182 6.633   -46.508 1    18.822  ? 245  LEU   A C   1 
ATOM   1692 O  O   . LEU   A 1  209 ? -10.786 7.704   -46.971 1    19.107  ? 245  LEU   A O   1 
ATOM   1693 C  CB  . LEU   A 1  209 ? -9.525  4.735   -46.596 1    23.334  ? 245  LEU   A CB  1 
ATOM   1694 C  CG  . LEU   A 1  209 ? -8.377  3.942   -45.97  1    22.071  ? 245  LEU   A CG  1 
ATOM   1695 C  CD1 . LEU   A 1  209 ? -7.897  2.874   -46.96  1    25.498  ? 245  LEU   A CD1 1 
ATOM   1696 C  CD2 . LEU   A 1  209 ? -7.261  4.842   -45.464 1    26.125  ? 245  LEU   A CD2 1 
ATOM   1697 N  N   . ASN   A 1  210 ? -12.425 6.123   -46.716 1    17.175  ? 246  ASN   A N   1 
ATOM   1698 C  CA  . ASN   A 1  210 ? -13.385 6.879   -47.499 1    17.992  ? 246  ASN   A CA  1 
ATOM   1699 C  C   . ASN   A 1  210 ? -13.898 8.07    -46.676 1    19.511  ? 246  ASN   A C   1 
ATOM   1700 O  O   . ASN   A 1  210 ? -14.057 9.174   -47.211 1    19.836  ? 246  ASN   A O   1 
ATOM   1701 C  CB  . ASN   A 1  210 ? -14.569 6.046   -47.948 1    20.765  ? 246  ASN   A CB  1 
ATOM   1702 C  CG  . ASN   A 1  210 ? -14.266 5.377   -49.264 1    22.88   ? 246  ASN   A CG  1 
ATOM   1703 O  OD1 . ASN   A 1  210 ? -14.284 6.041   -50.327 1    21.153  ? 246  ASN   A OD1 1 
ATOM   1704 N  ND2 . ASN   A 1  210 ? -13.934 4.094   -49.201 1    18.137  ? 246  ASN   A ND2 1 
ATOM   1705 N  N   . LEU   A 1  211 ? -14.026 7.874   -45.365 1    16.256  ? 247  LEU   A N   1 
ATOM   1706 C  CA  . LEU   A 1  211 ? -14.408 8.959   -44.469 1    16.241  ? 247  LEU   A CA  1 
ATOM   1707 C  C   . LEU   A 1  211 ? -13.319 10.039  -44.425 1    16.237  ? 247  LEU   A C   1 
ATOM   1708 O  O   . LEU   A 1  211 ? -13.62  11.235  -44.552 1    15.62   ? 247  LEU   A O   1 
ATOM   1709 C  CB  . LEU   A 1  211 ? -14.671 8.484   -43.038 1    16.018  ? 247  LEU   A CB  1 
ATOM   1710 C  CG  . LEU   A 1  211 ? -15.064 9.649   -42.096 1    19.687  ? 247  LEU   A CG  1 
ATOM   1711 C  CD1 . LEU   A 1  211 ? -16.414 10.362  -42.433 1    18.406  ? 247  LEU   A CD1 1 
ATOM   1712 C  CD2 . LEU   A 1  211 ? -15.107 9.117   -40.627 1    19.197  ? 247  LEU   A CD2 1 
ATOM   1713 N  N   . HIS   A 1  212 ? -12.069 9.578   -44.254 1    15.95   ? 248  HIS   A N   1 
ATOM   1714 C  CA  . HIS   A 1  212 ? -10.852 10.393  -44.22  1    16.987  ? 248  HIS   A CA  1 
ATOM   1715 C  C   . HIS   A 1  212 ? -10.754 11.232  -45.474 1    17.536  ? 248  HIS   A C   1 
ATOM   1716 O  O   . HIS   A 1  212 ? -10.608 12.485  -45.387 1    17.69   ? 248  HIS   A O   1 
ATOM   1717 C  CB  . HIS   A 1  212 ? -9.615  9.463   -44.105 1    18.61   ? 248  HIS   A CB  1 
ATOM   1718 C  CG  . HIS   A 1  212 ? -8.298  10.194  -44.058 1    18.978  ? 248  HIS   A CG  1 
ATOM   1719 N  ND1 . HIS   A 1  212 ? -7.661  10.632  -45.212 1    16.946  ? 248  HIS   A ND1 1 
ATOM   1720 C  CD2 . HIS   A 1  212 ? -7.506  10.546  -42.996 1    17.53   ? 248  HIS   A CD2 1 
ATOM   1721 C  CE1 . HIS   A 1  212 ? -6.486  11.204  -44.872 1    20.667  ? 248  HIS   A CE1 1 
ATOM   1722 N  NE2 . HIS   A 1  212 ? -6.328  11.136  -43.512 1    17.987  ? 248  HIS   A NE2 1 
ATOM   1723 N  N   . ALA   A 1  213 ? -10.938 10.552  -46.65  1    17.444  ? 249  ALA   A N   1 
ATOM   1724 C  CA  . ALA   A 1  213 ? -10.739 11.311  -47.899 1    19.283  ? 249  ALA   A CA  1 
ATOM   1725 C  C   . ALA   A 1  213 ? -11.804 12.414  -48.013 1    18.658  ? 249  ALA   A C   1 
ATOM   1726 O  O   . ALA   A 1  213 ? -11.529 13.491  -48.535 1    20.463  ? 249  ALA   A O   1 
ATOM   1727 C  CB  . ALA   A 1  213 ? -10.846 10.332  -49.088 1    16.263  ? 249  ALA   A CB  1 
ATOM   1728 N  N   . TYR   A 1  214 ? -13.075 12.079  -47.705 1    18.908  ? 250  TYR   A N   1 
ATOM   1729 C  CA  . TYR   A 1  214 ? -14.178 13.033  -47.845 1    17.248  ? 250  TYR   A CA  1 
ATOM   1730 C  C   . TYR   A 1  214 ? -13.978 14.201  -46.862 1    19.475  ? 250  TYR   A C   1 
ATOM   1731 O  O   . TYR   A 1  214 ? -14.126 15.407  -47.222 1    18.566  ? 250  TYR   A O   1 
ATOM   1732 C  CB  . TYR   A 1  214 ? -15.432 12.213  -47.501 1    17.287  ? 250  TYR   A CB  1 
ATOM   1733 C  CG  . TYR   A 1  214 ? -16.65  13.122  -47.395 1    18.191  ? 250  TYR   A CG  1 
ATOM   1734 C  CD1 . TYR   A 1  214 ? -17.303 13.581  -48.545 1    19.079  ? 250  TYR   A CD1 1 
ATOM   1735 C  CD2 . TYR   A 1  214 ? -17.141 13.526  -46.142 1    17.641  ? 250  TYR   A CD2 1 
ATOM   1736 C  CE1 . TYR   A 1  214 ? -18.408 14.429  -48.448 1    19.227  ? 250  TYR   A CE1 1 
ATOM   1737 C  CE2 . TYR   A 1  214 ? -18.278 14.326  -46.041 1    19.438  ? 250  TYR   A CE2 1 
ATOM   1738 C  CZ  . TYR   A 1  214 ? -18.818 14.875  -47.207 1    20.588  ? 250  TYR   A CZ  1 
ATOM   1739 O  OH  . TYR   A 1  214 ? -19.927 15.671  -47.199 1    19.849  ? 250  TYR   A OH  1 
ATOM   1740 N  N   . VAL   A 1  215 ? -13.59  13.876  -45.593 1    18.277  ? 251  VAL   A N   1 
ATOM   1741 C  CA  . VAL   A 1  215 ? -13.336 15.012  -44.659 1    17.124  ? 251  VAL   A CA  1 
ATOM   1742 C  C   . VAL   A 1  215 ? -12.138 15.85   -45.151 1    16.556  ? 251  VAL   A C   1 
ATOM   1743 O  O   . VAL   A 1  215 ? -12.108 17.092  -45.052 1    16.256  ? 251  VAL   A O   1 
ATOM   1744 C  CB  . VAL   A 1  215 ? -13.076 14.422  -43.258 1    17.732  ? 251  VAL   A CB  1 
ATOM   1745 C  CG1 . VAL   A 1  215 ? -12.6   15.501  -42.242 1    17.224  ? 251  VAL   A CG1 1 
ATOM   1746 C  CG2 . VAL   A 1  215 ? -14.381 13.79   -42.761 1    15.703  ? 251  VAL   A CG2 1 
ATOM   1747 N  N   . ARG   A 1  216 ? -11.075 15.224  -45.604 1    14.374  ? 252  ARG   A N   1 
ATOM   1748 C  CA  . ARG   A 1  216 ? -9.894  15.947  -46.155 1    15.428  ? 252  ARG   A CA  1 
ATOM   1749 C  C   . ARG   A 1  216 ? -10.31  16.958  -47.243 1    18.196  ? 252  ARG   A C   1 
ATOM   1750 O  O   . ARG   A 1  216 ? -9.85   18.124  -47.254 1    18.874  ? 252  ARG   A O   1 
ATOM   1751 C  CB  . ARG   A 1  216 ? -8.889  14.915  -46.706 1    13.033  ? 252  ARG   A CB  1 
ATOM   1752 C  CG  . ARG   A 1  216 ? -7.602  15.547  -47.236 1    14.98   ? 252  ARG   A CG  1 
ATOM   1753 C  CD  . ARG   A 1  216 ? -6.526  14.505  -47.526 1    16.582  ? 252  ARG   A CD  1 
ATOM   1754 N  NE  . ARG   A 1  216 ? -7.085  13.527  -48.487 1    18.061  ? 252  ARG   A NE  1 
ATOM   1755 C  CZ  . ARG   A 1  216 ? -6.631  12.29   -48.781 1    22.038  ? 252  ARG   A CZ  1 
ATOM   1756 N  NH1 . ARG   A 1  216 ? -5.478  11.889  -48.242 1    19.905  ? 252  ARG   A NH1 1 
ATOM   1757 N  NH2 . ARG   A 1  216 ? -7.339  11.496  -49.644 1    21.524  ? 252  ARG   A NH2 1 
ATOM   1758 N  N   . ARG   A 1  217 ? -11.233 16.526  -48.133 1    19.659  ? 253  ARG   A N   1 
ATOM   1759 C  CA  . ARG   A 1  217 ? -11.712 17.366  -49.229 1    17.082  ? 253  ARG   A CA  1 
ATOM   1760 C  C   . ARG   A 1  217 ? -12.439 18.565  -48.622 1    20.634  ? 253  ARG   A C   1 
ATOM   1761 O  O   . ARG   A 1  217 ? -12.262 19.703  -49.055 1    19.105  ? 253  ARG   A O   1 
ATOM   1762 C  CB  . ARG   A 1  217 ? -12.619 16.511  -50.155 1    19.68   ? 253  ARG   A CB  1 
ATOM   1763 C  CG  . ARG   A 1  217 ? -13.435 17.39   -51.127 1    22.23   ? 253  ARG   A CG  1 
ATOM   1764 C  CD  . ARG   A 1  217 ? -12.536 18.103  -52.232 1    21.471  ? 253  ARG   A CD  1 
ATOM   1765 N  NE  . ARG   A 1  217 ? -11.841 17.077  -53.009 1    22.321  ? 253  ARG   A NE  1 
ATOM   1766 C  CZ  . ARG   A 1  217 ? -11.018 17.254  -54.025 1    25.853  ? 253  ARG   A CZ  1 
ATOM   1767 N  NH1 . ARG   A 1  217 ? -10.342 16.208  -54.509 1    21.905  ? 253  ARG   A NH1 1 
ATOM   1768 N  NH2 . ARG   A 1  217 ? -10.814 18.473  -54.509 1    24.423  ? 253  ARG   A NH2 1 
ATOM   1769 N  N   . ALA   A 1  218 ? -13.281 18.315  -47.611 1    16.901  ? 254  ALA   A N   1 
ATOM   1770 C  CA  . ALA   A 1  218 ? -14.056 19.377  -46.991 1    20.177  ? 254  ALA   A CA  1 
ATOM   1771 C  C   . ALA   A 1  218 ? -13.142 20.342  -46.238 1    20.599  ? 254  ALA   A C   1 
ATOM   1772 O  O   . ALA   A 1  218 ? -13.308 21.585  -46.339 1    20.104  ? 254  ALA   A O   1 
ATOM   1773 C  CB  . ALA   A 1  218 ? -15.17  18.823  -46.107 1    18.752  ? 254  ALA   A CB  1 
ATOM   1774 N  N   . LEU   A 1  219 ? -12.134 19.795  -45.569 1    17.842  ? 255  LEU   A N   1 
ATOM   1775 C  CA  . LEU   A 1  219 ? -11.126 20.715  -44.978 1    19.424  ? 255  LEU   A CA  1 
ATOM   1776 C  C   . LEU   A 1  219 ? -10.392 21.56   -46.055 1    20.459  ? 255  LEU   A C   1 
ATOM   1777 O  O   . LEU   A 1  219 ? -10.082 22.734  -45.839 1    17.991  ? 255  LEU   A O   1 
ATOM   1778 C  CB  . LEU   A 1  219 ? -10.169 19.897  -44.126 1    16.735  ? 255  LEU   A CB  1 
ATOM   1779 C  CG  . LEU   A 1  219 ? -10.814 19.281  -42.855 1    16.755  ? 255  LEU   A CG  1 
ATOM   1780 C  CD1 . LEU   A 1  219 ? -9.723  18.453  -42.237 1    15.6    ? 255  LEU   A CD1 1 
ATOM   1781 C  CD2 . LEU   A 1  219 ? -11.255 20.43   -41.829 1    15.571  ? 255  LEU   A CD2 1 
ATOM   1782 N  N   . HIS   A 1  220 ? -10.025 20.924  -47.189 1    19.006  ? 256  HIS   A N   1 
ATOM   1783 C  CA  . HIS   A 1  220 ? -9.373  21.63   -48.275 1    20.997  ? 256  HIS   A CA  1 
ATOM   1784 C  C   . HIS   A 1  220 ? -10.25  22.82   -48.679 1    22.523  ? 256  HIS   A C   1 
ATOM   1785 O  O   . HIS   A 1  220 ? -9.703  23.908  -48.954 1    19.636  ? 256  HIS   A O   1 
ATOM   1786 C  CB  . HIS   A 1  220 ? -9.232  20.646  -49.44  1    19.907  ? 256  HIS   A CB  1 
ATOM   1787 C  CG  . HIS   A 1  220 ? -8.592  21.153  -50.679 1    22.491  ? 256  HIS   A CG  1 
ATOM   1788 N  ND1 . HIS   A 1  220 ? -9.273  21.756  -51.731 1    23.096  ? 256  HIS   A ND1 1 
ATOM   1789 C  CD2 . HIS   A 1  220 ? -7.302  21.036  -51.052 1    21.743  ? 256  HIS   A CD2 1 
ATOM   1790 C  CE1 . HIS   A 1  220 ? -8.383  22.083  -52.686 1    19.691  ? 256  HIS   A CE1 1 
ATOM   1791 N  NE2 . HIS   A 1  220 ? -7.19   21.612  -52.315 1    22.756  ? 256  HIS   A NE2 1 
ATOM   1792 N  N   . ARG   A 1  221 ? -11.572 22.596  -48.783 1    20.449  ? 257  ARG   A N   1 
ATOM   1793 C  CA  . ARG   A 1  221 ? -12.492 23.642  -49.22  1    23.426  ? 257  ARG   A CA  1 
ATOM   1794 C  C   . ARG   A 1  221 ? -12.501 24.772  -48.195 1    23.625  ? 257  ARG   A C   1 
ATOM   1795 O  O   . ARG   A 1  221 ? -12.571 25.925  -48.564 1    24.372  ? 257  ARG   A O   1 
ATOM   1796 C  CB  . ARG   A 1  221 ? -13.916 23.069  -49.323 1    29.65   ? 257  ARG   A CB  1 
ATOM   1797 C  CG  . ARG   A 1  221 ? -15.033 23.772  -50.077 1    41.477  ? 257  ARG   A CG  1 
ATOM   1798 C  CD  . ARG   A 1  221 ? -16.032 22.673  -50.556 1    51.656  ? 257  ARG   A CD  1 
ATOM   1799 N  NE  . ARG   A 1  221 ? -16.801 22.097  -49.441 1    42.658  ? 257  ARG   A NE  1 
ATOM   1800 C  CZ  . ARG   A 1  221 ? -16.888 20.844  -48.978 1    44.213  ? 257  ARG   A CZ  1 
ATOM   1801 N  NH1 . ARG   A 1  221 ? -16.411 19.776  -49.626 1    38.473  ? 257  ARG   A NH1 1 
ATOM   1802 N  NH2 . ARG   A 1  221 ? -17.51  20.674  -47.823 1    54.428  ? 257  ARG   A NH2 1 
ATOM   1803 N  N   . HIS   A 1  222 ? -12.471 24.478  -46.899 1    22.922  ? 258  HIS   A N   1 
ATOM   1804 C  CA  . HIS   A 1  222 ? -12.625 25.55   -45.88  1    24.054  ? 258  HIS   A CA  1 
ATOM   1805 C  C   . HIS   A 1  222 ? -11.285 26.231  -45.57  1    24.018  ? 258  HIS   A C   1 
ATOM   1806 O  O   . HIS   A 1  222 ? -11.224 27.443  -45.425 1    25.181  ? 258  HIS   A O   1 
ATOM   1807 C  CB  . HIS   A 1  222 ? -13.274 24.967  -44.588 1    21.866  ? 258  HIS   A CB  1 
ATOM   1808 C  CG  . HIS   A 1  222 ? -13.415 26.017  -43.535 1    28.856  ? 258  HIS   A CG  1 
ATOM   1809 N  ND1 . HIS   A 1  222 ? -14.517 26.843  -43.399 1    30.162  ? 258  HIS   A ND1 1 
ATOM   1810 C  CD2 . HIS   A 1  222 ? -12.534 26.414  -42.604 1    30.281  ? 258  HIS   A CD2 1 
ATOM   1811 C  CE1 . HIS   A 1  222 ? -14.293 27.701  -42.407 1    24.706  ? 258  HIS   A CE1 1 
ATOM   1812 N  NE2 . HIS   A 1  222 ? -13.11  27.462  -41.912 1    32.333  ? 258  HIS   A NE2 1 
ATOM   1813 N  N   . TYR   A 1  223 ? -10.199 25.449  -45.418 1    19.416  ? 259  TYR   A N   1 
ATOM   1814 C  CA  . TYR   A 1  223 ? -8.938  26.015  -44.909 1    24.063  ? 259  TYR   A CA  1 
ATOM   1815 C  C   . TYR   A 1  223 ? -7.995  26.405  -46.059 1    26.189  ? 259  TYR   A C   1 
ATOM   1816 O  O   . TYR   A 1  223 ? -6.944  27.023  -45.81  1    32.229  ? 259  TYR   A O   1 
ATOM   1817 C  CB  . TYR   A 1  223 ? -8.254  25.105  -43.878 1    22.748  ? 259  TYR   A CB  1 
ATOM   1818 C  CG  . TYR   A 1  223 ? -8.995  24.996  -42.542 1    22.121  ? 259  TYR   A CG  1 
ATOM   1819 C  CD1 . TYR   A 1  223 ? -8.946  26.066  -41.613 1    22.562  ? 259  TYR   A CD1 1 
ATOM   1820 C  CD2 . TYR   A 1  223 ? -9.788  23.879  -42.218 1    16.639  ? 259  TYR   A CD2 1 
ATOM   1821 C  CE1 . TYR   A 1  223 ? -9.597  26.008  -40.378 1    23.33   ? 259  TYR   A CE1 1 
ATOM   1822 C  CE2 . TYR   A 1  223 ? -10.414 23.792  -40.966 1    18.888  ? 259  TYR   A CE2 1 
ATOM   1823 C  CZ  . TYR   A 1  223 ? -10.376 24.89   -40.09  1    22.895  ? 259  TYR   A CZ  1 
ATOM   1824 O  OH  . TYR   A 1  223 ? -11.026 24.87   -38.911 1    21.335  ? 259  TYR   A OH  1 
ATOM   1825 N  N   . GLY   A 1  224 ? -8.335  25.99   -47.285 1    25.525  ? 260  GLY   A N   1 
ATOM   1826 C  CA  . GLY   A 1  224 ? -7.565  26.358  -48.46  1    24.987  ? 260  GLY   A CA  1 
ATOM   1827 C  C   . GLY   A 1  224 ? -6.56   25.313  -48.911 1    23.887  ? 260  GLY   A C   1 
ATOM   1828 O  O   . GLY   A 1  224 ? -5.959  24.563  -48.12  1    20.728  ? 260  GLY   A O   1 
ATOM   1829 N  N   . ALA   A 1  225 ? -6.351  25.312  -50.234 1    22.631  ? 261  ALA   A N   1 
ATOM   1830 C  CA  . ALA   A 1  225 ? -5.575  24.271  -50.887 1    21.484  ? 261  ALA   A CA  1 
ATOM   1831 C  C   . ALA   A 1  225 ? -4.15   24.34   -50.357 1    22.121  ? 261  ALA   A C   1 
ATOM   1832 O  O   . ALA   A 1  225 ? -3.419  23.372  -50.374 1    23.105  ? 261  ALA   A O   1 
ATOM   1833 C  CB  . ALA   A 1  225 ? -5.63   24.423  -52.442 1    21.704  ? 261  ALA   A CB  1 
ATOM   1834 N  N   . GLN   A 1  226 ? -3.704  25.538  -49.928 1    20.16   ? 262  GLN   A N   1 
ATOM   1835 C  CA  . GLN   A 1  226 ? -2.337  25.626  -49.448 1    23.277  ? 262  GLN   A CA  1 
ATOM   1836 C  C   . GLN   A 1  226 ? -2.161  24.976  -48.075 1    23.712  ? 262  GLN   A C   1 
ATOM   1837 O  O   . GLN   A 1  226 ? -0.995  24.839  -47.682 1    23.05   ? 262  GLN   A O   1 
ATOM   1838 C  CB  . GLN   A 1  226 ? -1.987  27.113  -49.268 1    21.835  ? 262  GLN   A CB  1 
ATOM   1839 C  CG  . GLN   A 1  226 ? -1.91   27.835  -50.61  1    22.367  ? 262  GLN   A CG  1 
ATOM   1840 C  CD  . GLN   A 1  226 ? -0.583  27.733  -51.359 1    25.508  ? 262  GLN   A CD  1 
ATOM   1841 O  OE1 . GLN   A 1  226 ? 0.366   27.081  -50.933 1    29.974  ? 262  GLN   A OE1 1 
ATOM   1842 N  NE2 . GLN   A 1  226 ? -0.547  28.314  -52.557 1    20.145  ? 262  GLN   A NE2 1 
ATOM   1843 N  N   . HIS   A 1  227 ? -3.27   24.635  -47.361 1    20.506  ? 263  HIS   A N   1 
ATOM   1844 C  CA  . HIS   A 1  227 ? -3.093  24.003  -46.05  1    22.042  ? 263  HIS   A CA  1 
ATOM   1845 C  C   . HIS   A 1  227 ? -3.466  22.515  -45.995 1    21.292  ? 263  HIS   A C   1 
ATOM   1846 O  O   . HIS   A 1  227 ? -3.326  21.913  -44.93  1    21.424  ? 263  HIS   A O   1 
ATOM   1847 C  CB  . HIS   A 1  227 ? -3.77   24.8    -44.943 1    20.661  ? 263  HIS   A CB  1 
ATOM   1848 C  CG  . HIS   A 1  227 ? -3.388  26.239  -44.942 1    28.493  ? 263  HIS   A CG  1 
ATOM   1849 N  ND1 . HIS   A 1  227 ? -2.173  26.754  -44.532 1    35.09   ? 263  HIS   A ND1 1 
ATOM   1850 C  CD2 . HIS   A 1  227 ? -4.065  27.273  -45.421 1    30.255  ? 263  HIS   A CD2 1 
ATOM   1851 C  CE1 . HIS   A 1  227 ? -2.135  28.05   -44.787 1    32.972  ? 263  HIS   A CE1 1 
ATOM   1852 N  NE2 . HIS   A 1  227 ? -3.302  28.407  -45.256 1    30.537  ? 263  HIS   A NE2 1 
ATOM   1853 N  N   . ILE   A 1  228 ? -4.031  21.955  -47.082 1    21.545  ? 264  ILE   A N   1 
ATOM   1854 C  CA  . ILE   A 1  228 ? -4.498  20.582  -47.16  1    19.811  ? 264  ILE   A CA  1 
ATOM   1855 C  C   . ILE   A 1  228 ? -3.983  19.965  -48.473 1    24.132  ? 264  ILE   A C   1 
ATOM   1856 O  O   . ILE   A 1  228 ? -4.278  20.434  -49.575 1    23.313  ? 264  ILE   A O   1 
ATOM   1857 C  CB  . ILE   A 1  228 ? -6.051  20.449  -47.132 1    21.722  ? 264  ILE   A CB  1 
ATOM   1858 C  CG1 . ILE   A 1  228 ? -6.741  21.066  -45.874 1    23.402  ? 264  ILE   A CG1 1 
ATOM   1859 C  CG2 . ILE   A 1  228 ? -6.418  18.962  -47.354 1    17.268  ? 264  ILE   A CG2 1 
ATOM   1860 C  CD1 . ILE   A 1  228 ? -6.297  20.43   -44.53  1    21.367  ? 264  ILE   A CD1 1 
ATOM   1861 N  N   . ASN   A 1  229 ? -3.288  18.848  -48.341 1    20.653  ? 265  ASN   A N   1 
ATOM   1862 C  CA  . ASN   A 1  229 ? -2.772  18.14   -49.489 1    23.838  ? 265  ASN   A CA  1 
ATOM   1863 C  C   . ASN   A 1  229 ? -3.78   17.029  -49.71  1    26.277  ? 265  ASN   A C   1 
ATOM   1864 O  O   . ASN   A 1  229 ? -3.957  16.178  -48.84  1    23.426  ? 265  ASN   A O   1 
ATOM   1865 C  CB  . ASN   A 1  229 ? -1.374  17.624  -49.162 1    24.87   ? 265  ASN   A CB  1 
ATOM   1866 C  CG  . ASN   A 1  229 ? -0.796  16.753  -50.252 1    23.429  ? 265  ASN   A CG  1 
ATOM   1867 O  OD1 . ASN   A 1  229 ? -1.475  16.334  -51.181 1    23.788  ? 265  ASN   A OD1 1 
ATOM   1868 N  ND2 . ASN   A 1  229 ? 0.434   16.364  -50.113 1    25.047  ? 265  ASN   A ND2 1 
ATOM   1869 N  N   . LEU   A 1  230 ? -4.461  17.088  -50.853 1    19.998  ? 266  LEU   A N   1 
ATOM   1870 C  CA  . LEU   A 1  230 ? -5.506  16.13   -51.153 1    23.044  ? 266  LEU   A CA  1 
ATOM   1871 C  C   . LEU   A 1  230 ? -4.97   14.713  -51.235 1    21.2    ? 266  LEU   A C   1 
ATOM   1872 O  O   . LEU   A 1  230 ? -5.796  13.833  -51.343 1    25.122  ? 266  LEU   A O   1 
ATOM   1873 C  CB  . LEU   A 1  230 ? -6.223  16.531  -52.432 1    21.582  ? 266  LEU   A CB  1 
ATOM   1874 C  CG  . LEU   A 1  230 ? -7.088  17.778  -52.247 1    21.551  ? 266  LEU   A CG  1 
ATOM   1875 C  CD1 . LEU   A 1  230 ? -7.489  18.244  -53.706 1    22.632  ? 266  LEU   A CD1 1 
ATOM   1876 C  CD2 . LEU   A 1  230 ? -8.308  17.556  -51.332 1    18.842  ? 266  LEU   A CD2 1 
ATOM   1877 N  N   . GLU   A 1  231 ? -3.636  14.497  -51.236 1    22.206  ? 267  GLU   A N   1 
ATOM   1878 C  CA  . GLU   A 1  231 ? -3.085  13.146  -51.29  1    20.91   ? 267  GLU   A CA  1 
ATOM   1879 C  C   . GLU   A 1  231 ? -2.278  12.841  -50.026 1    24.447  ? 267  GLU   A C   1 
ATOM   1880 O  O   . GLU   A 1  231 ? -1.55   11.838  -49.984 1    26.287  ? 267  GLU   A O   1 
ATOM   1881 C  CB  . GLU   A 1  231 ? -2.188  13.033  -52.538 1    25.641  ? 267  GLU   A CB  1 
ATOM   1882 C  CG  . GLU   A 1  231 ? -3.037  12.965  -53.812 1    33.268  ? 267  GLU   A CG  1 
ATOM   1883 C  CD  . GLU   A 1  231 ? -2.14   12.796  -55.029 1    39.661  ? 267  GLU   A CD  1 
ATOM   1884 O  OE1 . GLU   A 1  231 ? -2.438  13.458  -55.987 1    40.141  ? 267  GLU   A OE1 1 
ATOM   1885 O  OE2 . GLU   A 1  231 ? -1.118  12.084  -55.022 1    56.007  ? 267  GLU   A OE2 1 
ATOM   1886 N  N   . GLY   A 1  232 ? -2.385  13.733  -49.02  1    21.053  ? 268  GLY   A N   1 
ATOM   1887 C  CA  . GLY   A 1  232 ? -1.593  13.533  -47.84  1    19.413  ? 268  GLY   A CA  1 
ATOM   1888 C  C   . GLY   A 1  232 ? -2.415  13.398  -46.537 1    18.465  ? 268  GLY   A C   1 
ATOM   1889 O  O   . GLY   A 1  232 ? -3.671  13.27   -46.542 1    18.668  ? 268  GLY   A O   1 
ATOM   1890 N  N   . PRO   A 1  233 ? -1.676  13.401  -45.397 1    18.138  ? 269  PRO   A N   1 
ATOM   1891 C  CA  . PRO   A 1  233 ? -2.293  13.252  -44.076 1    22.489  ? 269  PRO   A CA  1 
ATOM   1892 C  C   . PRO   A 1  233 ? -3.022  14.533  -43.744 1    22.527  ? 269  PRO   A C   1 
ATOM   1893 O  O   . PRO   A 1  233 ? -2.686  15.552  -44.346 1    22.782  ? 269  PRO   A O   1 
ATOM   1894 C  CB  . PRO   A 1  233 ? -1.13   12.924  -43.123 1    23.335  ? 269  PRO   A CB  1 
ATOM   1895 C  CG  . PRO   A 1  233 ? 0.134   13.42   -43.856 1    24.614  ? 269  PRO   A CG  1 
ATOM   1896 C  CD  . PRO   A 1  233 ? -0.193  13.344  -45.363 1    21.359  ? 269  PRO   A CD  1 
ATOM   1897 N  N   . ILE   A 1  234 ? -3.992  14.483  -42.817 1    21.333  ? 270  ILE   A N   1 
ATOM   1898 C  CA  . ILE   A 1  234 ? -4.732  15.699  -42.507 1    19.45   ? 270  ILE   A CA  1 
ATOM   1899 C  C   . ILE   A 1  234 ? -3.991  16.335  -41.311 1    17.357  ? 270  ILE   A C   1 
ATOM   1900 O  O   . ILE   A 1  234 ? -3.651  15.66   -40.35  1    16.044  ? 270  ILE   A O   1 
ATOM   1901 C  CB  . ILE   A 1  234 ? -6.203  15.375  -42.121 1    18.766  ? 270  ILE   A CB  1 
ATOM   1902 C  CG1 . ILE   A 1  234 ? -6.982  14.745  -43.317 1    16.728  ? 270  ILE   A CG1 1 
ATOM   1903 C  CG2 . ILE   A 1  234 ? -6.903  16.631  -41.553 1    16.811  ? 270  ILE   A CG2 1 
ATOM   1904 C  CD1 . ILE   A 1  234 ? -8.394  14.246  -43.028 1    19.841  ? 270  ILE   A CD1 1 
ATOM   1905 N  N   . PRO   A 1  235 ? -3.783  17.659  -41.239 1    14.205  ? 271  PRO   A N   1 
ATOM   1906 C  CA  . PRO   A 1  235 ? -3.186  18.244  -40.038 1    16.166  ? 271  PRO   A CA  1 
ATOM   1907 C  C   . PRO   A 1  235 ? -4.031  17.971  -38.774 1    19.46   ? 271  PRO   A C   1 
ATOM   1908 O  O   . PRO   A 1  235 ? -5.257  18.139  -38.793 1    18.974  ? 271  PRO   A O   1 
ATOM   1909 C  CB  . PRO   A 1  235 ? -3.278  19.735  -40.41  1    16.773  ? 271  PRO   A CB  1 
ATOM   1910 C  CG  . PRO   A 1  235 ? -3.153  19.732  -41.933 1    18.164  ? 271  PRO   A CG  1 
ATOM   1911 C  CD  . PRO   A 1  235 ? -4.103  18.621  -42.321 1    17.956  ? 271  PRO   A CD  1 
ATOM   1912 N  N   . ALA   A 1  236 ? -3.388  17.626  -37.642 1    16.399  ? 272  ALA   A N   1 
ATOM   1913 C  CA  . ALA   A 1  236 ? -4.116  17.02   -36.511 1    19.662  ? 272  ALA   A CA  1 
ATOM   1914 C  C   . ALA   A 1  236 ? -4.973  18.002  -35.704 1    19.703  ? 272  ALA   A C   1 
ATOM   1915 O  O   . ALA   A 1  236 ? -5.631  17.534  -34.755 1    18.397  ? 272  ALA   A O   1 
ATOM   1916 C  CB  . ALA   A 1  236 ? -3.168  16.343  -35.548 1    16.364  ? 272  ALA   A CB  1 
ATOM   1917 N  N   . HIS   A 1  237 ? -4.872  19.339  -35.979 1    17.419  ? 273  HIS   A N   1 
ATOM   1918 C  CA  . HIS   A 1  237 ? -5.628  20.282  -35.147 1    18.646  ? 273  HIS   A CA  1 
ATOM   1919 C  C   . HIS   A 1  237 ? -6.984  20.677  -35.761 1    17.785  ? 273  HIS   A C   1 
ATOM   1920 O  O   . HIS   A 1  237 ? -7.632  21.522  -35.193 1    16.03   ? 273  HIS   A O   1 
ATOM   1921 C  CB  . HIS   A 1  237 ? -4.824  21.557  -34.794 1    16.096  ? 273  HIS   A CB  1 
ATOM   1922 C  CG  . HIS   A 1  237 ? -4.504  22.329  -36.04  1    18.657  ? 273  HIS   A CG  1 
ATOM   1923 N  ND1 . HIS   A 1  237 ? -4.051  21.681  -37.18  1    21.405  ? 273  HIS   A ND1 1 
ATOM   1924 C  CD2 . HIS   A 1  237 ? -4.512  23.645  -36.338 1    15.808  ? 273  HIS   A CD2 1 
ATOM   1925 C  CE1 . HIS   A 1  237 ? -3.844  22.558  -38.162 1    18.71   ? 273  HIS   A CE1 1 
ATOM   1926 N  NE2 . HIS   A 1  237 ? -4.122  23.767  -37.68  1    17.52   ? 273  HIS   A NE2 1 
ATOM   1927 N  N   . LEU   A 1  238 ? -7.427  20.121  -36.891 1    16.891  ? 274  LEU   A N   1 
ATOM   1928 C  CA  . LEU   A 1  238 ? -8.617  20.612  -37.625 1    18.864  ? 274  LEU   A CA  1 
ATOM   1929 C  C   . LEU   A 1  238 ? -9.868  19.756  -37.426 1    18.544  ? 274  LEU   A C   1 
ATOM   1930 O  O   . LEU   A 1  238 ? -10.838 19.974  -38.158 1    17.053  ? 274  LEU   A O   1 
ATOM   1931 C  CB  . LEU   A 1  238 ? -8.245  20.656  -39.121 1    16.673  ? 274  LEU   A CB  1 
ATOM   1932 C  CG  . LEU   A 1  238 ? -6.997  21.5    -39.445 1    20.955  ? 274  LEU   A CG  1 
ATOM   1933 C  CD1 . LEU   A 1  238 ? -6.725  21.379  -40.947 1    18.52   ? 274  LEU   A CD1 1 
ATOM   1934 C  CD2 . LEU   A 1  238 ? -7.216  22.985  -39.075 1    19.563  ? 274  LEU   A CD2 1 
ATOM   1935 N  N   . LEU   A 1  239 ? -9.81   18.694  -36.566 1    17.642  ? 275  LEU   A N   1 
ATOM   1936 C  CA  . LEU   A 1  239 ? -10.886 17.706  -36.521 1    17.414  ? 275  LEU   A CA  1 
ATOM   1937 C  C   . LEU   A 1  239 ? -11.865 17.991  -35.349 1    18.321  ? 275  LEU   A C   1 
ATOM   1938 O  O   . LEU   A 1  239 ? -12.804 17.24   -35.167 1    21.182  ? 275  LEU   A O   1 
ATOM   1939 C  CB  . LEU   A 1  239 ? -10.241 16.309  -36.384 1    17.677  ? 275  LEU   A CB  1 
ATOM   1940 C  CG  . LEU   A 1  239 ? -9.539  15.76   -37.626 1    18.554  ? 275  LEU   A CG  1 
ATOM   1941 C  CD1 . LEU   A 1  239 ? -10.415 15.831  -38.911 1    18.875  ? 275  LEU   A CD1 1 
ATOM   1942 C  CD2 . LEU   A 1  239 ? -8.263  16.52   -37.82  1    18.697  ? 275  LEU   A CD2 1 
ATOM   1943 N  N   . GLY   A 1  240 ? -11.74  19.093  -34.58  1    15.672  ? 276  GLY   A N   1 
ATOM   1944 C  CA  . GLY   A 1  240 ? -12.833 19.53   -33.691 1    16.202  ? 276  GLY   A CA  1 
ATOM   1945 C  C   . GLY   A 1  240 ? -12.653 19      -32.238 1    16.245  ? 276  GLY   A C   1 
ATOM   1946 O  O   . GLY   A 1  240 ? -13.443 19.304  -31.323 1    16.673  ? 276  GLY   A O   1 
ATOM   1947 N  N   . ASN   A 1  241 ? -11.509 18.3    -32.049 1    19.318  ? 277  ASN   A N   1 
ATOM   1948 C  CA  . ASN   A 1  241 ? -11.19  17.551  -30.846 1    18.755  ? 277  ASN   A CA  1 
ATOM   1949 C  C   . ASN   A 1  241 ? -9.673  17.625  -30.63  1    16.877  ? 277  ASN   A C   1 
ATOM   1950 O  O   . ASN   A 1  241 ? -8.898  17.529  -31.592 1    19.177  ? 277  ASN   A O   1 
ATOM   1951 C  CB  . ASN   A 1  241 ? -11.665 16.106  -30.998 1    16.445  ? 277  ASN   A CB  1 
ATOM   1952 C  CG  . ASN   A 1  241 ? -11.182 15.247  -29.857 1    14.929  ? 277  ASN   A CG  1 
ATOM   1953 O  OD1 . ASN   A 1  241 ? -10.1   14.643  -29.945 1    15.72   ? 277  ASN   A OD1 1 
ATOM   1954 N  ND2 . ASN   A 1  241 ? -11.982 15.117  -28.801 1    15.101  ? 277  ASN   A ND2 1 
ATOM   1955 N  N   . MET   A 1  242 ? -9.271  17.696  -29.359 1    14.557  ? 278  MET   A N   1 
ATOM   1956 C  CA  . MET   A 1  242 ? -7.845  17.924  -29.055 1    16.766  ? 278  MET   A CA  1 
ATOM   1957 C  C   . MET   A 1  242 ? -6.935  16.84   -29.64  1    15.096  ? 278  MET   A C   1 
ATOM   1958 O  O   . MET   A 1  242 ? -5.804  17.13   -29.984 1    19.103  ? 278  MET   A O   1 
ATOM   1959 C  CB  . MET   A 1  242 ? -7.629  18.097  -27.523 1    16.611  ? 278  MET   A CB  1 
ATOM   1960 C  CG  . MET   A 1  242 ? -6.18   18.307  -27.085 1    16.045  ? 278  MET   A CG  1 
ATOM   1961 S  SD  . MET   A 1  242 ? -5.613  19.899  -27.779 1    18.872  ? 278  MET   A SD  1 
ATOM   1962 C  CE  . MET   A 1  242 ? -6.266  21.153  -26.634 1    16.611  ? 278  MET   A CE  1 
ATOM   1963 N  N   . TRP   A 1  243 ? -7.361  15.569  -29.649 1    13.288  ? 279  TRP   A N   1 
ATOM   1964 C  CA  . TRP   A 1  243 ? -6.578  14.448  -30.091 1    13.859  ? 279  TRP   A CA  1 
ATOM   1965 C  C   . TRP   A 1  243 ? -6.993  13.98   -31.488 1    16.809  ? 279  TRP   A C   1 
ATOM   1966 O  O   . TRP   A 1  243 ? -6.512  12.909  -31.901 1    16.085  ? 279  TRP   A O   1 
ATOM   1967 C  CB  . TRP   A 1  243 ? -6.777  13.291  -29.085 1    17.783  ? 279  TRP   A CB  1 
ATOM   1968 C  CG  . TRP   A 1  243 ? -6.371  13.797  -27.748 1    16.518  ? 279  TRP   A CG  1 
ATOM   1969 C  CD1 . TRP   A 1  243 ? -5.075  13.968  -27.35  1    17.789  ? 279  TRP   A CD1 1 
ATOM   1970 C  CD2 . TRP   A 1  243 ? -7.226  14.364  -26.741 1    17.028  ? 279  TRP   A CD2 1 
ATOM   1971 N  NE1 . TRP   A 1  243 ? -5.079  14.617  -26.141 1    16.314  ? 279  TRP   A NE1 1 
ATOM   1972 C  CE2 . TRP   A 1  243 ? -6.371  14.853  -25.753 1    16.556  ? 279  TRP   A CE2 1 
ATOM   1973 C  CE3 . TRP   A 1  243 ? -8.634  14.503  -26.608 1    13.714  ? 279  TRP   A CE3 1 
ATOM   1974 C  CZ2 . TRP   A 1  243 ? -6.863  15.465  -24.6   1    16.336  ? 279  TRP   A CZ2 1 
ATOM   1975 C  CZ3 . TRP   A 1  243 ? -9.127  15.097  -25.464 1    18.79   ? 279  TRP   A CZ3 1 
ATOM   1976 C  CH2 . TRP   A 1  243 ? -8.24   15.589  -24.491 1    16.812  ? 279  TRP   A CH2 1 
ATOM   1977 N  N   . ALA   A 1  244 ? -7.959  14.688  -32.129 1    17.619  ? 280  ALA   A N   1 
ATOM   1978 C  CA  . ALA   A 1  244 ? -8.571  14.232  -33.386 1    17.525  ? 280  ALA   A CA  1 
ATOM   1979 C  C   . ALA   A 1  244 ? -9.034  12.775  -33.248 1    19.25   ? 280  ALA   A C   1 
ATOM   1980 O  O   . ALA   A 1  244 ? -8.919  12.033  -34.21  1    16.172  ? 280  ALA   A O   1 
ATOM   1981 C  CB  . ALA   A 1  244 ? -7.564  14.336  -34.54  1    15.544  ? 280  ALA   A CB  1 
ATOM   1982 N  N   . GLN   A 1  245 ? -9.577  12.384  -32.093 1    17.428  ? 281  GLN   A N   1 
ATOM   1983 C  CA  . GLN   A 1  245 ? -10.029 11.026  -31.853 1    20.239  ? 281  GLN   A CA  1 
ATOM   1984 C  C   . GLN   A 1  245 ? -11.489 10.863  -32.285 1    18.346  ? 281  GLN   A C   1 
ATOM   1985 O  O   . GLN   A 1  245 ? -11.893 9.754   -32.668 1    20.433  ? 281  GLN   A O   1 
ATOM   1986 C  CB  . GLN   A 1  245 ? -9.823  10.509  -30.435 1    15.462  ? 281  GLN   A CB  1 
ATOM   1987 C  CG  . GLN   A 1  245 ? -10.715 11.246  -29.459 1    18.849  ? 281  GLN   A CG  1 
ATOM   1988 C  CD  . GLN   A 1  245 ? -10.337 10.958  -28.016 1    20.424  ? 281  GLN   A CD  1 
ATOM   1989 O  OE1 . GLN   A 1  245 ? -9.217  11.238  -27.592 1    16.701  ? 281  GLN   A OE1 1 
ATOM   1990 N  NE2 . GLN   A 1  245 ? -11.247 10.343  -27.273 1    17.622  ? 281  GLN   A NE2 1 
ATOM   1991 N  N   A THR   A 1  246 ? -12.279 11.953  -32.214 0.5  18.878  ? 282  THR   A N   1 
ATOM   1992 N  N   B THR   A 1  246 ? -12.25  11.963  -32.228 0.5  17.75   ? 282  THR   A N   1 
ATOM   1993 C  CA  A THR   A 1  246 ? -13.646 11.973  -32.724 0.5  19.948  ? 282  THR   A CA  1 
ATOM   1994 C  CA  B THR   A 1  246 ? -13.606 11.956  -32.748 0.5  18.041  ? 282  THR   A CA  1 
ATOM   1995 C  C   A THR   A 1  246 ? -13.781 13.283  -33.492 0.5  18.49   ? 282  THR   A C   1 
ATOM   1996 C  C   B THR   A 1  246 ? -13.749 13.273  -33.507 0.5  17.545  ? 282  THR   A C   1 
ATOM   1997 O  O   A THR   A 1  246 ? -13.163 14.277  -33.108 0.5  18.617  ? 282  THR   A O   1 
ATOM   1998 O  O   B THR   A 1  246 ? -13.067 14.245  -33.162 0.5  17.425  ? 282  THR   A O   1 
ATOM   1999 C  CB  A THR   A 1  246 ? -14.673 11.858  -31.588 0.5  21.353  ? 282  THR   A CB  1 
ATOM   2000 C  CB  B THR   A 1  246 ? -14.61  11.758  -31.604 0.5  17.957  ? 282  THR   A CB  1 
ATOM   2001 O  OG1 A THR   A 1  246 ? -15.974 12.242  -32.039 0.5  19.314  ? 282  THR   A OG1 1 
ATOM   2002 O  OG1 B THR   A 1  246 ? -14.237 12.734  -30.629 0.5  19.294  ? 282  THR   A OG1 1 
ATOM   2003 C  CG2 A THR   A 1  246 ? -14.307 12.743  -30.41  0.5  21.839  ? 282  THR   A CG2 1 
ATOM   2004 C  CG2 B THR   A 1  246 ? -14.584 10.341  -31.041 0.5  13.36   ? 282  THR   A CG2 1 
ATOM   2005 N  N   . TRP   A 1  247 ? -14.46  13.23   -34.639 1    16.701  ? 283  TRP   A N   1 
ATOM   2006 C  CA  . TRP   A 1  247 ? -14.469 14.371  -35.553 1    17.059  ? 283  TRP   A CA  1 
ATOM   2007 C  C   . TRP   A 1  247 ? -15.855 15.021  -35.608 1    20.455  ? 283  TRP   A C   1 
ATOM   2008 O  O   . TRP   A 1  247 ? -16.083 15.864  -36.474 1    18.407  ? 283  TRP   A O   1 
ATOM   2009 C  CB  . TRP   A 1  247 ? -14.105 13.899  -36.953 1    18.746  ? 283  TRP   A CB  1 
ATOM   2010 C  CG  . TRP   A 1  247 ? -12.752 13.252  -37.039 1    17.226  ? 283  TRP   A CG  1 
ATOM   2011 C  CD1 . TRP   A 1  247 ? -11.771 13.088  -36.11  1    17.886  ? 283  TRP   A CD1 1 
ATOM   2012 C  CD2 . TRP   A 1  247 ? -12.234 12.723  -38.254 1    16.683  ? 283  TRP   A CD2 1 
ATOM   2013 N  NE1 . TRP   A 1  247 ? -10.691 12.428  -36.65  1    19.206  ? 283  TRP   A NE1 1 
ATOM   2014 C  CE2 . TRP   A 1  247 ? -10.944 12.219  -37.974 1    16.528  ? 283  TRP   A CE2 1 
ATOM   2015 C  CE3 . TRP   A 1  247 ? -12.761 12.597  -39.545 1    17.705  ? 283  TRP   A CE3 1 
ATOM   2016 C  CZ2 . TRP   A 1  247 ? -10.165 11.655  -38.965 1    16.115  ? 283  TRP   A CZ2 1 
ATOM   2017 C  CZ3 . TRP   A 1  247 ? -11.964 12.052  -40.535 1    17.165  ? 283  TRP   A CZ3 1 
ATOM   2018 C  CH2 . TRP   A 1  247 ? -10.673 11.609  -40.247 1    19.289  ? 283  TRP   A CH2 1 
ATOM   2019 N  N   . SER   A 1  248 ? -16.788 14.681  -34.678 1    18.578  ? 284  SER   A N   1 
ATOM   2020 C  CA  . SER   A 1  248 ? -18.18  15.111  -34.909 1    21.617  ? 284  SER   A CA  1 
ATOM   2021 C  C   . SER   A 1  248 ? -18.348 16.638  -34.722 1    20.732  ? 284  SER   A C   1 
ATOM   2022 O  O   . SER   A 1  248 ? -19.291 17.229  -35.264 1    18.691  ? 284  SER   A O   1 
ATOM   2023 C  CB  . SER   A 1  248 ? -19.197 14.33   -34.098 1    28.264  ? 284  SER   A CB  1 
ATOM   2024 O  OG  . SER   A 1  248 ? -18.902 14.473  -32.739 1    29.264  ? 284  SER   A OG  1 
ATOM   2025 N  N   . ASN   A 1  249 ? -17.41  17.298  -34.038 1    15.682  ? 285  ASN   A N   1 
ATOM   2026 C  CA  . ASN   A 1  249 ? -17.482 18.759  -33.93  1    17.829  ? 285  ASN   A CA  1 
ATOM   2027 C  C   . ASN   A 1  249 ? -17.245 19.532  -35.232 1    18.006  ? 285  ASN   A C   1 
ATOM   2028 O  O   . ASN   A 1  249 ? -17.55  20.752  -35.306 1    20.125  ? 285  ASN   A O   1 
ATOM   2029 C  CB  . ASN   A 1  249 ? -16.676 19.38   -32.779 1    15.169  ? 285  ASN   A CB  1 
ATOM   2030 C  CG  . ASN   A 1  249 ? -17.169 18.899  -31.446 1    17.124  ? 285  ASN   A CG  1 
ATOM   2031 O  OD1 . ASN   A 1  249 ? -18.361 19.072  -31.135 1    22.946  ? 285  ASN   A OD1 1 
ATOM   2032 N  ND2 . ASN   A 1  249 ? -16.299 18.401  -30.585 1    17.507  ? 285  ASN   A ND2 1 
ATOM   2033 N  N   . ILE   A 1  250 ? -16.789 18.88   -36.303 1    15.934  ? 286  ILE   A N   1 
ATOM   2034 C  CA  . ILE   A 1  250 ? -16.662 19.589  -37.567 1    15.73   ? 286  ILE   A CA  1 
ATOM   2035 C  C   . ILE   A 1  250 ? -17.764 19.115  -38.536 1    16.451  ? 286  ILE   A C   1 
ATOM   2036 O  O   . ILE   A 1  250 ? -17.643 19.237  -39.773 1    17.662  ? 286  ILE   A O   1 
ATOM   2037 C  CB  . ILE   A 1  250 ? -15.237 19.484  -38.169 1    19.925  ? 286  ILE   A CB  1 
ATOM   2038 C  CG1 . ILE   A 1  250 ? -14.834 18.046  -38.489 1    21.772  ? 286  ILE   A CG1 1 
ATOM   2039 C  CG2 . ILE   A 1  250 ? -14.149 20.206  -37.34  1    15.436  ? 286  ILE   A CG2 1 
ATOM   2040 C  CD1 . ILE   A 1  250 ? -13.82  17.94   -39.654 1    21.36   ? 286  ILE   A CD1 1 
ATOM   2041 N  N   . TYR   A 1  251 ? -18.858 18.573  -37.967 1    17.123  ? 287  TYR   A N   1 
ATOM   2042 C  CA  . TYR   A 1  251 ? -20.017 18.252  -38.802 1    21.046  ? 287  TYR   A CA  1 
ATOM   2043 C  C   . TYR   A 1  251 ? -20.433 19.402  -39.749 1    20.485  ? 287  TYR   A C   1 
ATOM   2044 O  O   . TYR   A 1  251 ? -20.664 19.136  -40.945 1    21.626  ? 287  TYR   A O   1 
ATOM   2045 C  CB  . TYR   A 1  251 ? -21.182 17.877  -37.88  1    18.814  ? 287  TYR   A CB  1 
ATOM   2046 C  CG  . TYR   A 1  251 ? -22.433 17.557  -38.679 1    23.805  ? 287  TYR   A CG  1 
ATOM   2047 C  CD1 . TYR   A 1  251 ? -22.58  16.312  -39.305 1    23.672  ? 287  TYR   A CD1 1 
ATOM   2048 C  CD2 . TYR   A 1  251 ? -23.465 18.514  -38.798 1    26.719  ? 287  TYR   A CD2 1 
ATOM   2049 C  CE1 . TYR   A 1  251 ? -23.675 16.015  -40.099 1    27.833  ? 287  TYR   A CE1 1 
ATOM   2050 C  CE2 . TYR   A 1  251 ? -24.615 18.186  -39.509 1    29.923  ? 287  TYR   A CE2 1 
ATOM   2051 C  CZ  . TYR   A 1  251 ? -24.711 16.948  -40.142 1    35.819  ? 287  TYR   A CZ  1 
ATOM   2052 O  OH  . TYR   A 1  251 ? -25.771 16.7    -40.952 1    34.145  ? 287  TYR   A OH  1 
ATOM   2053 N  N   . ASP   A 1  252 ? -20.57  20.62   -39.21  1    20.21   ? 288  ASP   A N   1 
ATOM   2054 C  CA  . ASP   A 1  252 ? -20.783 21.855  -39.963 1    26.215  ? 288  ASP   A CA  1 
ATOM   2055 C  C   . ASP   A 1  252 ? -19.907 21.944  -41.218 1    26.853  ? 288  ASP   A C   1 
ATOM   2056 O  O   . ASP   A 1  252 ? -20.391 22.416  -42.234 1    27.188  ? 288  ASP   A O   1 
ATOM   2057 C  CB  . ASP   A 1  252 ? -20.67  23.112  -39.091 1    33.379  ? 288  ASP   A CB  1 
ATOM   2058 C  CG  . ASP   A 1  252 ? -19.247 23.322  -38.567 1    49.534  ? 288  ASP   A CG  1 
ATOM   2059 O  OD1 . ASP   A 1  252 ? -18.678 22.346  -38.029 1    61.59   ? 288  ASP   A OD1 1 
ATOM   2060 O  OD2 . ASP   A 1  252 ? -18.655 24.413  -38.747 1    53.289  ? 288  ASP   A OD2 1 
ATOM   2061 N  N   . LEU   A 1  253 ? -18.635 21.517  -41.207 1    21.342  ? 289  LEU   A N   1 
ATOM   2062 C  CA  . LEU   A 1  253 ? -17.823 21.661  -42.422 1    24.115  ? 289  LEU   A CA  1 
ATOM   2063 C  C   . LEU   A 1  253 ? -18.087 20.559  -43.446 1    26.775  ? 289  LEU   A C   1 
ATOM   2064 O  O   . LEU   A 1  253 ? -17.569 20.682  -44.591 1    22.993  ? 289  LEU   A O   1 
ATOM   2065 C  CB  . LEU   A 1  253 ? -16.339 21.577  -42.056 1    21.968  ? 289  LEU   A CB  1 
ATOM   2066 C  CG  . LEU   A 1  253 ? -15.895 22.623  -41.041 1    27.086  ? 289  LEU   A CG  1 
ATOM   2067 C  CD1 . LEU   A 1  253 ? -14.368 22.567  -40.734 1    23.358  ? 289  LEU   A CD1 1 
ATOM   2068 C  CD2 . LEU   A 1  253 ? -16.29  23.957  -41.671 1    25.94   ? 289  LEU   A CD2 1 
ATOM   2069 N  N   . VAL   A 1  254 ? -18.669 19.414  -42.986 1    21.243  ? 290  VAL   A N   1 
ATOM   2070 C  CA  . VAL   A 1  254 ? -18.685 18.237  -43.843 1    24.483  ? 290  VAL   A CA  1 
ATOM   2071 C  C   . VAL   A 1  254 ? -20.103 17.755  -44.158 1    24.853  ? 290  VAL   A C   1 
ATOM   2072 O  O   . VAL   A 1  254 ? -20.26  16.666  -44.706 1    29.934  ? 290  VAL   A O   1 
ATOM   2073 C  CB  . VAL   A 1  254 ? -17.839 17.071  -43.282 1    23.949  ? 290  VAL   A CB  1 
ATOM   2074 C  CG1 . VAL   A 1  254 ? -16.408 17.551  -42.937 1    25.462  ? 290  VAL   A CG1 1 
ATOM   2075 C  CG2 . VAL   A 1  254 ? -18.519 16.455  -42.062 1    17.46   ? 290  VAL   A CG2 1 
ATOM   2076 N  N   . VAL   A 1  255 ? -21.145 18.511  -43.804 1    28.562  ? 291  VAL   A N   1 
ATOM   2077 C  CA  . VAL   A 1  255 ? -22.539 18.075  -43.951 1    26.83   ? 291  VAL   A CA  1 
ATOM   2078 C  C   . VAL   A 1  255 ? -22.812 17.537  -45.363 1    24.258  ? 291  VAL   A C   1 
ATOM   2079 O  O   . VAL   A 1  255 ? -22.689 18.253  -46.341 1    23.804  ? 291  VAL   A O   1 
ATOM   2080 C  CB  . VAL   A 1  255 ? -23.514 19.251  -43.807 1    32.774  ? 291  VAL   A CB  1 
ATOM   2081 C  CG1 . VAL   A 1  255 ? -24.93  18.706  -43.653 1    37.573  ? 291  VAL   A CG1 1 
ATOM   2082 C  CG2 . VAL   A 1  255 ? -23.099 20.197  -42.705 1    37.284  ? 291  VAL   A CG2 1 
ATOM   2083 N  N   . PRO   A 1  256 ? -23.198 16.251  -45.53  1    20.869  ? 292  PRO   A N   1 
ATOM   2084 C  CA  . PRO   A 1  256 ? -23.476 15.692  -46.86  1    22.655  ? 292  PRO   A CA  1 
ATOM   2085 C  C   . PRO   A 1  256 ? -24.617 16.472  -47.518 1    30.322  ? 292  PRO   A C   1 
ATOM   2086 O  O   . PRO   A 1  256 ? -24.531 16.749  -48.695 1    31.503  ? 292  PRO   A O   1 
ATOM   2087 C  CB  . PRO   A 1  256 ? -23.818 14.189  -46.552 1    21.538  ? 292  PRO   A CB  1 
ATOM   2088 C  CG  . PRO   A 1  256 ? -23.115 13.953  -45.236 1    19.681  ? 292  PRO   A CG  1 
ATOM   2089 C  CD  . PRO   A 1  256 ? -23.252 15.241  -44.438 1    18.898  ? 292  PRO   A CD  1 
ATOM   2090 N  N   . PHE   A 1  257 ? -25.654 16.885  -46.758 1    26.854  ? 293  PHE   A N   1 
ATOM   2091 C  CA  . PHE   A 1  257 ? -26.835 17.484  -47.403 1    32.938  ? 293  PHE   A CA  1 
ATOM   2092 C  C   . PHE   A 1  257 ? -27.201 18.763  -46.669 1    33.004  ? 293  PHE   A C   1 
ATOM   2093 O  O   . PHE   A 1  257 ? -28.091 18.734  -45.786 1    31.72   ? 293  PHE   A O   1 
ATOM   2094 C  CB  . PHE   A 1  257 ? -27.977 16.468  -47.489 1    29.306  ? 293  PHE   A CB  1 
ATOM   2095 C  CG  . PHE   A 1  257 ? -27.778 15.333  -48.486 1    28.614  ? 293  PHE   A CG  1 
ATOM   2096 C  CD1 . PHE   A 1  257 ? -27.939 15.55   -49.848 1    34.373  ? 293  PHE   A CD1 1 
ATOM   2097 C  CD2 . PHE   A 1  257 ? -27.432 14.051  -48.066 1    28.421  ? 293  PHE   A CD2 1 
ATOM   2098 C  CE1 . PHE   A 1  257 ? -27.744 14.535  -50.776 1    39.168  ? 293  PHE   A CE1 1 
ATOM   2099 C  CE2 . PHE   A 1  257 ? -27.276 13.028  -48.98  1    41.29   ? 293  PHE   A CE2 1 
ATOM   2100 C  CZ  . PHE   A 1  257 ? -27.426 13.271  -50.347 1    40.991  ? 293  PHE   A CZ  1 
ATOM   2101 N  N   . PRO   A 1  258 ? -26.44  19.872  -46.917 1    39.342  ? 294  PRO   A N   1 
ATOM   2102 C  CA  . PRO   A 1  258 ? -26.649 21.171  -46.249 1    38.296  ? 294  PRO   A CA  1 
ATOM   2103 C  C   . PRO   A 1  258 ? -28.092 21.623  -46.46  1    33.223  ? 294  PRO   A C   1 
ATOM   2104 O  O   . PRO   A 1  258 ? -28.664 22.242  -45.557 1    41.172  ? 294  PRO   A O   1 
ATOM   2105 C  CB  . PRO   A 1  258 ? -25.61  22.183  -46.792 1    41.917  ? 294  PRO   A CB  1 
ATOM   2106 C  CG  . PRO   A 1  258 ? -25.101 21.497  -48.045 1    41.907  ? 294  PRO   A CG  1 
ATOM   2107 C  CD  . PRO   A 1  258 ? -25.347 19.949  -47.9   1    39.297  ? 294  PRO   A CD  1 
ATOM   2108 N  N   . SER   A 1  259 ? -28.715 21.145  -47.553 1    32.44   ? 295  SER   A N   1 
ATOM   2109 C  CA  . SER   A 1  259 ? -30.152 21.332  -47.797 1    44.017  ? 295  SER   A CA  1 
ATOM   2110 C  C   . SER   A 1  259 ? -31.067 20.847  -46.659 1    45.214  ? 295  SER   A C   1 
ATOM   2111 O  O   . SER   A 1  259 ? -32.129 21.41   -46.442 1    48.568  ? 295  SER   A O   1 
ATOM   2112 C  CB  . SER   A 1  259 ? -30.614 20.728  -49.143 1    49.079  ? 295  SER   A CB  1 
ATOM   2113 O  OG  . SER   A 1  259 ? -30.909 19.331  -49.072 1    51.263  ? 295  SER   A OG  1 
ATOM   2114 N  N   . ALA   A 1  260 ? -30.758 19.701  -46.04  1    39.612  ? 296  ALA   A N   1 
ATOM   2115 C  CA  . ALA   A 1  260 ? -31.45  19.223  -44.847 1    41.282  ? 296  ALA   A CA  1 
ATOM   2116 C  C   . ALA   A 1  260 ? -30.731 19.801  -43.636 1    45.451  ? 296  ALA   A C   1 
ATOM   2117 O  O   . ALA   A 1  260 ? -29.773 19.194  -43.137 1    51.728  ? 296  ALA   A O   1 
ATOM   2118 C  CB  . ALA   A 1  260 ? -31.466 17.691  -44.774 1    37.332  ? 296  ALA   A CB  1 
ATOM   2119 N  N   . PRO   A 1  261 ? -31.204 20.962  -43.124 1    44.433  ? 297  PRO   A N   1 
ATOM   2120 C  CA  . PRO   A 1  261 ? -30.397 21.736  -42.168 1    45.201  ? 297  PRO   A CA  1 
ATOM   2121 C  C   . PRO   A 1  261 ? -30.487 20.897  -40.892 1    46.975  ? 297  PRO   A C   1 
ATOM   2122 O  O   . PRO   A 1  261 ? -31.458 20.125  -40.71  1    44.299  ? 297  PRO   A O   1 
ATOM   2123 C  CB  . PRO   A 1  261 ? -31.17  23.089  -42.079 1    44.317  ? 297  PRO   A CB  1 
ATOM   2124 C  CG  . PRO   A 1  261 ? -32.625 22.737  -42.458 1    41.899  ? 297  PRO   A CG  1 
ATOM   2125 C  CD  . PRO   A 1  261 ? -32.568 21.493  -43.364 1    35.672  ? 297  PRO   A CD  1 
ATOM   2126 N  N   . SER   A 1  262 ? -29.512 21.055  -39.995 1    39.712  ? 298  SER   A N   1 
ATOM   2127 C  CA  . SER   A 1  262 ? -29.6   20.228  -38.796 1    42.57   ? 298  SER   A CA  1 
ATOM   2128 C  C   . SER   A 1  262 ? -29.731 21.133  -37.575 1    35.747  ? 298  SER   A C   1 
ATOM   2129 O  O   . SER   A 1  262 ? -29.406 22.33   -37.656 1    40.736  ? 298  SER   A O   1 
ATOM   2130 C  CB  . SER   A 1  262 ? -28.492 19.16   -38.705 1    59.27   ? 298  SER   A CB  1 
ATOM   2131 O  OG  . SER   A 1  262 ? -28.788 18.162  -37.732 1    60.639  ? 298  SER   A OG  1 
ATOM   2132 N  N   . MET   A 1  263 ? -30.358 20.61   -36.528 1    33.261  ? 299  MET   A N   1 
ATOM   2133 C  CA  . MET   A 1  263 ? -30.66  21.414  -35.347 1    38.317  ? 299  MET   A CA  1 
ATOM   2134 C  C   . MET   A 1  263 ? -29.402 21.617  -34.508 1    45.997  ? 299  MET   A C   1 
ATOM   2135 O  O   . MET   A 1  263 ? -28.551 20.731  -34.393 1    49.163  ? 299  MET   A O   1 
ATOM   2136 C  CB  . MET   A 1  263 ? -31.823 20.878  -34.509 1    33.788  ? 299  MET   A CB  1 
ATOM   2137 C  CG  . MET   A 1  263 ? -32.389 21.895  -33.579 1    38.452  ? 299  MET   A CG  1 
ATOM   2138 S  SD  . MET   A 1  263 ? -34.151 21.591  -33.575 1    50.245  ? 299  MET   A SD  1 
ATOM   2139 C  CE  . MET   A 1  263 ? -34.481 22.324  -31.953 1    37.009  ? 299  MET   A CE  1 
ATOM   2140 N  N   . ASP   A 1  264 ? -29.251 22.834  -33.971 1    34.129  ? 300  ASP   A N   1 
ATOM   2141 C  CA  . ASP   A 1  264 ? -28.138 23.017  -33.059 1    35.117  ? 300  ASP   A CA  1 
ATOM   2142 C  C   . ASP   A 1  264 ? -28.539 22.378  -31.719 1    32.615  ? 300  ASP   A C   1 
ATOM   2143 O  O   . ASP   A 1  264 ? -29.218 23.025  -30.913 1    29.016  ? 300  ASP   A O   1 
ATOM   2144 C  CB  . ASP   A 1  264 ? -27.814 24.506  -32.962 1    35.723  ? 300  ASP   A CB  1 
ATOM   2145 C  CG  . ASP   A 1  264 ? -26.78  24.911  -31.93  1    36.25   ? 300  ASP   A CG  1 
ATOM   2146 O  OD1 . ASP   A 1  264 ? -26.444 24.078  -31.063 1    51.167  ? 300  ASP   A OD1 1 
ATOM   2147 O  OD2 . ASP   A 1  264 ? -26.331 26.059  -31.999 1    45.494  ? 300  ASP   A OD2 1 
ATOM   2148 N  N   . THR   A 1  265 ? -28.092 21.137  -31.482 1    24.647  ? 301  THR   A N   1 
ATOM   2149 C  CA  . THR   A 1  265 ? -28.453 20.42   -30.26  1    25.764  ? 301  THR   A CA  1 
ATOM   2150 C  C   . THR   A 1  265 ? -27.924 21.139  -29.028 1    27.597  ? 301  THR   A C   1 
ATOM   2151 O  O   . THR   A 1  265 ? -28.613 21.075  -28.005 1    27.806  ? 301  THR   A O   1 
ATOM   2152 C  CB  . THR   A 1  265 ? -27.894 19      -30.283 1    28.45   ? 301  THR   A CB  1 
ATOM   2153 O  OG1 . THR   A 1  265 ? -26.526 19.384  -30.521 1    27.684  ? 301  THR   A OG1 1 
ATOM   2154 C  CG2 . THR   A 1  265 ? -28.35  18.245  -31.509 1    27.282  ? 301  THR   A CG2 1 
ATOM   2155 N  N   . THR   A 1  266 ? -26.769 21.871  -29.144 1    30.255  ? 302  THR   A N   1 
ATOM   2156 C  CA  . THR   A 1  266 ? -26.207 22.544  -27.98  1    28.304  ? 302  THR   A CA  1 
ATOM   2157 C  C   . THR   A 1  266 ? -27.184 23.629  -27.537 1    35.423  ? 302  THR   A C   1 
ATOM   2158 O  O   . THR   A 1  266 ? -27.619 23.65   -26.37  1    32.976  ? 302  THR   A O   1 
ATOM   2159 C  CB  . THR   A 1  266 ? -24.744 23.018  -28.09  1    31.677  ? 302  THR   A CB  1 
ATOM   2160 O  OG1 . THR   A 1  266 ? -23.974 21.835  -28.183 1    32.937  ? 302  THR   A OG1 1 
ATOM   2161 C  CG2 . THR   A 1  266 ? -24.233 23.661  -26.808 1    32.043  ? 302  THR   A CG2 1 
ATOM   2162 N  N   . GLU   A 1  267 ? -27.563 24.481  -28.508 1    34.958  ? 303  GLU   A N   1 
ATOM   2163 C  CA  . GLU   A 1  267 ? -28.431 25.632  -28.26  1    39.719  ? 303  GLU   A CA  1 
ATOM   2164 C  C   . GLU   A 1  267 ? -29.768 25.157  -27.665 1    36.289  ? 303  GLU   A C   1 
ATOM   2165 O  O   . GLU   A 1  267 ? -30.322 25.794  -26.735 1    34.386  ? 303  GLU   A O   1 
ATOM   2166 C  CB  . GLU   A 1  267 ? -28.477 26.446  -29.568 1    52.784  ? 303  GLU   A CB  1 
ATOM   2167 C  CG  . GLU   A 1  267 ? -29.01  27.874  -29.422 1    73.462  ? 303  GLU   A CG  1 
ATOM   2168 C  CD  . GLU   A 1  267 ? -28.773 28.568  -28.077 1    88.047  ? 303  GLU   A CD  1 
ATOM   2169 O  OE1 . GLU   A 1  267 ? -27.599 28.887  -27.717 1    75.451  ? 303  GLU   A OE1 1 
ATOM   2170 O  OE2 . GLU   A 1  267 ? -29.801 28.763  -27.366 1    90.623  ? 303  GLU   A OE2 1 
ATOM   2171 N  N   . ALA   A 1  268 ? -30.248 24.013  -28.195 1    30.925  ? 304  ALA   A N   1 
ATOM   2172 C  CA  . ALA   A 1  268 ? -31.517 23.417  -27.815 1    31.627  ? 304  ALA   A CA  1 
ATOM   2173 C  C   . ALA   A 1  268 ? -31.458 23.017  -26.338 1    35.766  ? 304  ALA   A C   1 
ATOM   2174 O  O   . ALA   A 1  268 ? -32.341 23.377  -25.542 1    33.138  ? 304  ALA   A O   1 
ATOM   2175 C  CB  . ALA   A 1  268 ? -31.8   22.243  -28.738 1    31.667  ? 304  ALA   A CB  1 
ATOM   2176 N  N   . MET   A 1  269 ? -30.368 22.323  -25.963 1    35.602  ? 305  MET   A N   1 
ATOM   2177 C  CA  . MET   A 1  269 ? -30.19  21.889  -24.582 1    35.528  ? 305  MET   A CA  1 
ATOM   2178 C  C   . MET   A 1  269 ? -30.181 23.117  -23.659 1    29.263  ? 305  MET   A C   1 
ATOM   2179 O  O   . MET   A 1  269 ? -30.882 23.164  -22.627 1    31.065  ? 305  MET   A O   1 
ATOM   2180 C  CB  . MET   A 1  269 ? -28.902 21.06   -24.419 1    30.861  ? 305  MET   A CB  1 
ATOM   2181 C  CG  . MET   A 1  269 ? -28.953 19.698  -25.075 1    33.555  ? 305  MET   A CG  1 
ATOM   2182 S  SD  . MET   A 1  269 ? -27.516 18.595  -25.028 1    27.652  ? 305  MET   A SD  1 
ATOM   2183 C  CE  . MET   A 1  269 ? -27.53  18.048  -23.317 1    22.635  ? 305  MET   A CE  1 
ATOM   2184 N  N   . LEU   A 1  270 ? -29.357 24.11   -24.04  1    34.992  ? 306  LEU   A N   1 
ATOM   2185 C  CA  . LEU   A 1  270 ? -29.143 25.306  -23.228 1    34.855  ? 306  LEU   A CA  1 
ATOM   2186 C  C   . LEU   A 1  270 ? -30.462 26.068  -23.123 1    39.233  ? 306  LEU   A C   1 
ATOM   2187 O  O   . LEU   A 1  270 ? -31.021 26.195  -22.021 1    36.458  ? 306  LEU   A O   1 
ATOM   2188 C  CB  . LEU   A 1  270 ? -27.992 26.166  -23.739 1    37.896  ? 306  LEU   A CB  1 
ATOM   2189 C  CG  . LEU   A 1  270 ? -26.596 25.543  -23.614 1    43.103  ? 306  LEU   A CG  1 
ATOM   2190 C  CD1 . LEU   A 1  270 ? -25.584 26.323  -24.468 1    46.243  ? 306  LEU   A CD1 1 
ATOM   2191 C  CD2 . LEU   A 1  270 ? -26.198 25.515  -22.133 1    34.954  ? 306  LEU   A CD2 1 
ATOM   2192 N  N   . LYS   A 1  271 ? -31.01  26.445  -24.293 1    47.898  ? 307  LYS   A N   1 
ATOM   2193 C  CA  . LYS   A 1  271 ? -32.332 27.063  -24.401 1    42.515  ? 307  LYS   A CA  1 
ATOM   2194 C  C   . LYS   A 1  271 ? -33.373 26.309  -23.585 1    46.033  ? 307  LYS   A C   1 
ATOM   2195 O  O   . LYS   A 1  271 ? -34.143 26.951  -22.877 1    50.3    ? 307  LYS   A O   1 
ATOM   2196 C  CB  . LYS   A 1  271 ? -32.763 27.228  -25.85  1    49.874  ? 307  LYS   A CB  1 
ATOM   2197 C  CG  . LYS   A 1  271 ? -34.049 28.051  -25.984 1    60.838  ? 307  LYS   A CG  1 
ATOM   2198 C  CD  . LYS   A 1  271 ? -34.267 28.576  -27.403 1    60.041  ? 307  LYS   A CD  1 
ATOM   2199 C  CE  . LYS   A 1  271 ? -35.314 29.666  -27.479 1    58.76   ? 307  LYS   A CE  1 
ATOM   2200 N  NZ  . LYS   A 1  271 ? -35.58  29.946  -28.899 1    52.053  ? 307  LYS   A NZ  1 
ATOM   2201 N  N   . GLN   A 1  272 ? -33.4   24.969  -23.624 1    38.095  ? 308  GLN   A N   1 
ATOM   2202 C  CA  . GLN   A 1  272 ? -34.454 24.272  -22.888 1    34.4    ? 308  GLN   A CA  1 
ATOM   2203 C  C   . GLN   A 1  272 ? -34.073 24.074  -21.416 1    33.719  ? 308  GLN   A C   1 
ATOM   2204 O  O   . GLN   A 1  272 ? -34.738 23.347  -20.681 1    35.617  ? 308  GLN   A O   1 
ATOM   2205 C  CB  . GLN   A 1  272 ? -34.802 22.91   -23.505 1    40.635  ? 308  GLN   A CB  1 
ATOM   2206 C  CG  . GLN   A 1  272 ? -35.742 23.025  -24.698 1    51.53   ? 308  GLN   A CG  1 
ATOM   2207 C  CD  . GLN   A 1  272 ? -35.542 21.928  -25.718 1    57.421  ? 308  GLN   A CD  1 
ATOM   2208 O  OE1 . GLN   A 1  272 ? -35.635 20.735  -25.4   1    72.14   ? 308  GLN   A OE1 1 
ATOM   2209 N  NE2 . GLN   A 1  272 ? -35.212 22.325  -26.945 1    52.208  ? 308  GLN   A NE2 1 
ATOM   2210 N  N   . GLY   A 1  273 ? -33.002 24.711  -20.952 1    33.737  ? 309  GLY   A N   1 
ATOM   2211 C  CA  . GLY   A 1  273 ? -32.699 24.645  -19.528 1    37.486  ? 309  GLY   A CA  1 
ATOM   2212 C  C   . GLY   A 1  273 ? -32.064 23.318  -19.084 1    39.912  ? 309  GLY   A C   1 
ATOM   2213 O  O   . GLY   A 1  273 ? -32.058 23.032  -17.882 1    32.313  ? 309  GLY   A O   1 
ATOM   2214 N  N   . TRP   A 1  274 ? -31.491 22.518  -20.007 1    37.647  ? 310  TRP   A N   1 
ATOM   2215 C  CA  . TRP   A 1  274 ? -30.901 21.256  -19.551 1    33.957  ? 310  TRP   A CA  1 
ATOM   2216 C  C   . TRP   A 1  274 ? -29.801 21.543  -18.538 1    28.338  ? 310  TRP   A C   1 
ATOM   2217 O  O   . TRP   A 1  274 ? -29.122 22.533  -18.699 1    31.978  ? 310  TRP   A O   1 
ATOM   2218 C  CB  . TRP   A 1  274 ? -30.295 20.474  -20.726 1    27.147  ? 310  TRP   A CB  1 
ATOM   2219 C  CG  . TRP   A 1  274 ? -31.334 19.723  -21.504 1    29.488  ? 310  TRP   A CG  1 
ATOM   2220 C  CD1 . TRP   A 1  274 ? -32.338 20.259  -22.254 1    27.126  ? 310  TRP   A CD1 1 
ATOM   2221 C  CD2 . TRP   A 1  274 ? -31.41  18.294  -21.666 1    27.432  ? 310  TRP   A CD2 1 
ATOM   2222 N  NE1 . TRP   A 1  274 ? -33.062 19.255  -22.839 1    34.097  ? 310  TRP   A NE1 1 
ATOM   2223 C  CE2 . TRP   A 1  274 ? -32.532 18.041  -22.481 1    31.286  ? 310  TRP   A CE2 1 
ATOM   2224 C  CE3 . TRP   A 1  274 ? -30.657 17.213  -21.189 1    31.188  ? 310  TRP   A CE3 1 
ATOM   2225 C  CZ2 . TRP   A 1  274 ? -32.917 16.75   -22.829 1    32.142  ? 310  TRP   A CZ2 1 
ATOM   2226 C  CZ3 . TRP   A 1  274 ? -31.048 15.93   -21.518 1    36.028  ? 310  TRP   A CZ3 1 
ATOM   2227 C  CH2 . TRP   A 1  274 ? -32.165 15.711  -22.334 1    34.682  ? 310  TRP   A CH2 1 
ATOM   2228 N  N   . THR   A 1  275 ? -29.57  20.653  -17.556 1    35.813  ? 311  THR   A N   1 
ATOM   2229 C  CA  . THR   A 1  275 ? -28.45  20.75   -16.62  1    28.726  ? 311  THR   A CA  1 
ATOM   2230 C  C   . THR   A 1  275 ? -27.684 19.414  -16.671 1    30.043  ? 311  THR   A C   1 
ATOM   2231 O  O   . THR   A 1  275 ? -28.218 18.383  -17.154 1    22.746  ? 311  THR   A O   1 
ATOM   2232 C  CB  . THR   A 1  275 ? -28.928 20.998  -15.178 1    31.426  ? 311  THR   A CB  1 
ATOM   2233 O  OG1 . THR   A 1  275 ? -29.679 19.831  -14.846 1    28.476  ? 311  THR   A OG1 1 
ATOM   2234 C  CG2 . THR   A 1  275 ? -29.814 22.23   -15.01  1    30.101  ? 311  THR   A CG2 1 
ATOM   2235 N  N   . PRO   A 1  276 ? -26.465 19.373  -16.071 1    31.762  ? 312  PRO   A N   1 
ATOM   2236 C  CA  . PRO   A 1  276 ? -25.771 18.099  -15.856 1    23.832  ? 312  PRO   A CA  1 
ATOM   2237 C  C   . PRO   A 1  276 ? -26.674 17.109  -15.125 1    24.065  ? 312  PRO   A C   1 
ATOM   2238 O  O   . PRO   A 1  276 ? -26.749 15.962  -15.572 1    28.372  ? 312  PRO   A O   1 
ATOM   2239 C  CB  . PRO   A 1  276 ? -24.514 18.556  -15.067 1    24.275  ? 312  PRO   A CB  1 
ATOM   2240 C  CG  . PRO   A 1  276 ? -24.217 19.967  -15.633 1    20.92   ? 312  PRO   A CG  1 
ATOM   2241 C  CD  . PRO   A 1  276 ? -25.622 20.555  -15.692 1    27.208  ? 312  PRO   A CD  1 
ATOM   2242 N  N   . ARG   A 1  277 ? -27.434 17.546  -14.089 1    28.143  ? 313  ARG   A N   1 
ATOM   2243 C  CA  . ARG   A 1  277 ? -28.311 16.602  -13.396 1    30.093  ? 313  ARG   A CA  1 
ATOM   2244 C  C   . ARG   A 1  277 ? -29.369 16.043  -14.344 1    30.248  ? 313  ARG   A C   1 
ATOM   2245 O  O   . ARG   A 1  277 ? -29.657 14.823  -14.317 1    25.735  ? 313  ARG   A O   1 
ATOM   2246 C  CB  . ARG   A 1  277 ? -29.007 17.048  -12.101 1    38.346  ? 313  ARG   A CB  1 
ATOM   2247 C  CG  . ARG   A 1  277 ? -28.01  17.309  -10.981 1    58.696  ? 313  ARG   A CG  1 
ATOM   2248 C  CD  . ARG   A 1  277 ? -28.267 16.728  -9.581  1    66.341  ? 313  ARG   A CD  1 
ATOM   2249 N  NE  . ARG   A 1  277 ? -27.154 17.23   -8.763  1    65.081  ? 313  ARG   A NE  1 
ATOM   2250 C  CZ  . ARG   A 1  277 ? -27.319 17.915  -7.639  1    91.426  ? 313  ARG   A CZ  1 
ATOM   2251 N  NH1 . ARG   A 1  277 ? -26.38  18.746  -7.221  1    98.15   ? 313  ARG   A NH1 1 
ATOM   2252 N  NH2 . ARG   A 1  277 ? -28.47  17.862  -6.991  1    111.82  ? 313  ARG   A NH2 1 
ATOM   2253 N  N   . ARG   A 1  278 ? -29.915 16.914  -15.209 1    30.095  ? 314  ARG   A N   1 
ATOM   2254 C  CA  . ARG   A 1  278 ? -30.92  16.448  -16.161 1    33.24   ? 314  ARG   A CA  1 
ATOM   2255 C  C   . ARG   A 1  278 ? -30.328 15.378  -17.098 1    29.228  ? 314  ARG   A C   1 
ATOM   2256 O  O   . ARG   A 1  278 ? -30.972 14.385  -17.464 1    35.383  ? 314  ARG   A O   1 
ATOM   2257 C  CB  . ARG   A 1  278 ? -31.501 17.588  -17.006 1    35.048  ? 314  ARG   A CB  1 
ATOM   2258 C  CG  . ARG   A 1  278 ? -32.472 17.143  -18.1   1    48.177  ? 314  ARG   A CG  1 
ATOM   2259 C  CD  . ARG   A 1  278 ? -33.929 16.682  -17.815 1    54.502  ? 314  ARG   A CD  1 
ATOM   2260 N  NE  . ARG   A 1  278 ? -34.73  16.619  -19.055 1    56.85   ? 314  ARG   A NE  1 
ATOM   2261 C  CZ  . ARG   A 1  278 ? -35.034 17.686  -19.832 1    49.32   ? 314  ARG   A CZ  1 
ATOM   2262 N  NH1 . ARG   A 1  278 ? -34.813 18.939  -19.433 1    46.134  ? 314  ARG   A NH1 1 
ATOM   2263 N  NH2 . ARG   A 1  278 ? -35.61  17.509  -20.999 1    44.596  ? 314  ARG   A NH2 1 
ATOM   2264 N  N   . MET   A 1  279 ? -29.077 15.627  -17.498 1    28.123  ? 315  MET   A N   1 
ATOM   2265 C  CA  . MET   A 1  279 ? -28.387 14.757  -18.418 1    21.956  ? 315  MET   A CA  1 
ATOM   2266 C  C   . MET   A 1  279 ? -28.285 13.371  -17.796 1    18.227  ? 315  MET   A C   1 
ATOM   2267 O  O   . MET   A 1  279 ? -28.658 12.4    -18.444 1    19.198  ? 315  MET   A O   1 
ATOM   2268 C  CB  . MET   A 1  279 ? -27.026 15.387  -18.721 1    25.027  ? 315  MET   A CB  1 
ATOM   2269 C  CG  . MET   A 1  279 ? -27.232 16.599  -19.69  1    23.949  ? 315  MET   A CG  1 
ATOM   2270 S  SD  . MET   A 1  279 ? -25.718 17.585  -19.755 1    22.717  ? 315  MET   A SD  1 
ATOM   2271 C  CE  . MET   A 1  279 ? -24.575 16.561  -20.678 1    27.064  ? 315  MET   A CE  1 
ATOM   2272 N  N   . PHE   A 1  280 ? -27.883 13.338  -16.524 1    19.334  ? 316  PHE   A N   1 
ATOM   2273 C  CA  . PHE   A 1  280 ? -27.696 12.047  -15.857 1    22.872  ? 316  PHE   A CA  1 
ATOM   2274 C  C   . PHE   A 1  280 ? -29.041 11.371  -15.61  1    20.687  ? 316  PHE   A C   1 
ATOM   2275 O  O   . PHE   A 1  280 ? -29.16  10.128  -15.69  1    21.361  ? 316  PHE   A O   1 
ATOM   2276 C  CB  . PHE   A 1  280 ? -26.785 12.158  -14.638 1    19.651  ? 316  PHE   A CB  1 
ATOM   2277 C  CG  . PHE   A 1  280 ? -25.326 12.227  -15.048 1    23.415  ? 316  PHE   A CG  1 
ATOM   2278 C  CD1 . PHE   A 1  280 ? -24.577 11.061  -15.254 1    22.186  ? 316  PHE   A CD1 1 
ATOM   2279 C  CD2 . PHE   A 1  280 ? -24.69  13.454  -15.225 1    18.994  ? 316  PHE   A CD2 1 
ATOM   2280 C  CE1 . PHE   A 1  280 ? -23.249 11.154  -15.68  1    19.694  ? 316  PHE   A CE1 1 
ATOM   2281 C  CE2 . PHE   A 1  280 ? -23.392 13.518  -15.683 1    23.963  ? 316  PHE   A CE2 1 
ATOM   2282 C  CZ  . PHE   A 1  280 ? -22.652 12.379  -15.872 1    18.736  ? 316  PHE   A CZ  1 
ATOM   2283 N  N   . LYS   A 1  281 ? -30.068 12.17   -15.292 1    21.379  ? 317  LYS   A N   1 
ATOM   2284 C  CA  . LYS   A 1  281 ? -31.416 11.57   -15.094 1    22.715  ? 317  LYS   A CA  1 
ATOM   2285 C  C   . LYS   A 1  281 ? -31.973 10.928  -16.351 1    22.524  ? 317  LYS   A C   1 
ATOM   2286 O  O   . LYS   A 1  281 ? -32.57  9.83    -16.309 1    27.597  ? 317  LYS   A O   1 
ATOM   2287 C  CB  . LYS   A 1  281 ? -32.443 12.616  -14.634 1    25.535  ? 317  LYS   A CB  1 
ATOM   2288 C  CG  . LYS   A 1  281 ? -32.166 13.171  -13.21  1    31.464  ? 317  LYS   A CG  1 
ATOM   2289 C  CD  . LYS   A 1  281 ? -32.87  12.568  -11.988 1    43.859  ? 317  LYS   A CD  1 
ATOM   2290 C  CE  . LYS   A 1  281 ? -32.613 13.49   -10.765 1    53.782  ? 317  LYS   A CE  1 
ATOM   2291 N  NZ  . LYS   A 1  281 ? -32.693 12.875  -9.435  1    51.678  ? 317  LYS   A NZ  1 
ATOM   2292 N  N   . GLU   A 1  282 ? -31.696 11.552  -17.497 1    21.91   ? 318  GLU   A N   1 
ATOM   2293 C  CA  . GLU   A 1  282 ? -32.084 10.874  -18.727 1    21.878  ? 318  GLU   A CA  1 
ATOM   2294 C  C   . GLU   A 1  282 ? -31.33  9.593   -18.944 1    23.334  ? 318  GLU   A C   1 
ATOM   2295 O  O   . GLU   A 1  282 ? -31.905 8.692   -19.559 1    22.222  ? 318  GLU   A O   1 
ATOM   2296 C  CB  . GLU   A 1  282 ? -31.878 11.74   -19.971 1    27.864  ? 318  GLU   A CB  1 
ATOM   2297 C  CG  . GLU   A 1  282 ? -32.744 12.988  -19.743 1    33.058  ? 318  GLU   A CG  1 
ATOM   2298 C  CD  . GLU   A 1  282 ? -34.291 12.914  -19.922 1    40.414  ? 318  GLU   A CD  1 
ATOM   2299 O  OE1 . GLU   A 1  282 ? -34.75  11.843  -20.404 1    35.009  ? 318  GLU   A OE1 1 
ATOM   2300 O  OE2 . GLU   A 1  282 ? -35.029 13.943  -19.694 1    45.553  ? 318  GLU   A OE2 1 
ATOM   2301 N  N   . ALA   A 1  283 ? -30.023 9.574   -18.622 1    21.775  ? 319  ALA   A N   1 
ATOM   2302 C  CA  . ALA   A 1  283 ? -29.322 8.299   -18.811 1    21.711  ? 319  ALA   A CA  1 
ATOM   2303 C  C   . ALA   A 1  283 ? -29.907 7.26    -17.848 1    19.621  ? 319  ALA   A C   1 
ATOM   2304 O  O   . ALA   A 1  283 ? -30.132 6.114   -18.211 1    24.285  ? 319  ALA   A O   1 
ATOM   2305 C  CB  . ALA   A 1  283 ? -27.822 8.476   -18.628 1    17.721  ? 319  ALA   A CB  1 
ATOM   2306 N  N   . ASP   A 1  284 ? -30.183 7.677   -16.605 1    19.562  ? 320  ASP   A N   1 
ATOM   2307 C  CA  . ASP   A 1  284 ? -30.784 6.741   -15.672 1    23.148  ? 320  ASP   A CA  1 
ATOM   2308 C  C   . ASP   A 1  284 ? -32.139 6.22    -16.216 1    21.43   ? 320  ASP   A C   1 
ATOM   2309 O  O   . ASP   A 1  284 ? -32.441 5.007   -16.232 1    22.55   ? 320  ASP   A O   1 
ATOM   2310 C  CB  . ASP   A 1  284 ? -30.782 7.392   -14.295 1    21.032  ? 320  ASP   A CB  1 
ATOM   2311 C  CG  . ASP   A 1  284 ? -31.23  6.469   -13.172 1    27.821  ? 320  ASP   A CG  1 
ATOM   2312 O  OD1 . ASP   A 1  284 ? -30.535 5.459   -12.932 1    20.98   ? 320  ASP   A OD1 1 
ATOM   2313 O  OD2 . ASP   A 1  284 ? -32.22  6.811   -12.498 1    28.849  ? 320  ASP   A OD2 1 
ATOM   2314 N  N   . ASP   A 1  285 ? -32.9   7.154   -16.781 1    23.144  ? 321  ASP   A N   1 
ATOM   2315 C  CA  . ASP   A 1  285 ? -34.15  6.745   -17.437 1    25.593  ? 321  ASP   A CA  1 
ATOM   2316 C  C   . ASP   A 1  285 ? -33.992 5.655   -18.509 1    26.58   ? 321  ASP   A C   1 
ATOM   2317 O  O   . ASP   A 1  285 ? -34.796 4.709   -18.568 1    24.2    ? 321  ASP   A O   1 
ATOM   2318 C  CB  . ASP   A 1  285 ? -34.94  7.939   -17.923 1    23.808  ? 321  ASP   A CB  1 
ATOM   2319 C  CG  . ASP   A 1  285 ? -36.268 7.502   -18.533 1    33.561  ? 321  ASP   A CG  1 
ATOM   2320 O  OD1 . ASP   A 1  285 ? -37.103 7.074   -17.759 1    32.711  ? 321  ASP   A OD1 1 
ATOM   2321 O  OD2 . ASP   A 1  285 ? -36.43  7.487   -19.762 1    28.457  ? 321  ASP   A OD2 1 
ATOM   2322 N  N   . PHE   A 1  286 ? -32.95  5.791   -19.358 1    24.511  ? 322  PHE   A N   1 
ATOM   2323 C  CA  . PHE   A 1  286 ? -32.769 4.873   -20.457 1    21.444  ? 322  PHE   A CA  1 
ATOM   2324 C  C   . PHE   A 1  286 ? -32.508 3.508   -19.872 1    18.547  ? 322  PHE   A C   1 
ATOM   2325 O  O   . PHE   A 1  286 ? -33.088 2.499   -20.329 1    22.252  ? 322  PHE   A O   1 
ATOM   2326 C  CB  . PHE   A 1  286 ? -31.719 5.48    -21.408 1    16.534  ? 322  PHE   A CB  1 
ATOM   2327 C  CG  . PHE   A 1  286 ? -31.846 4.969   -22.834 1    17.334  ? 322  PHE   A CG  1 
ATOM   2328 C  CD1 . PHE   A 1  286 ? -31.834 3.598   -23.114 1    17.98   ? 322  PHE   A CD1 1 
ATOM   2329 C  CD2 . PHE   A 1  286 ? -32.046 5.854   -23.884 1    22.757  ? 322  PHE   A CD2 1 
ATOM   2330 C  CE1 . PHE   A 1  286 ? -31.976 3.133   -24.408 1    20.164  ? 322  PHE   A CE1 1 
ATOM   2331 C  CE2 . PHE   A 1  286 ? -32.232 5.369   -25.183 1    22.212  ? 322  PHE   A CE2 1 
ATOM   2332 C  CZ  . PHE   A 1  286 ? -32.089 4.008   -25.437 1    19.876  ? 322  PHE   A CZ  1 
ATOM   2333 N  N   . PHE   A 1  287 ? -31.649 3.497   -18.848 1    19.886  ? 323  PHE   A N   1 
ATOM   2334 C  CA  . PHE   A 1  287 ? -31.29  2.196   -18.251 1    22.706  ? 323  PHE   A CA  1 
ATOM   2335 C  C   . PHE   A 1  287 ? -32.539 1.522   -17.646 1    20.921  ? 323  PHE   A C   1 
ATOM   2336 O  O   . PHE   A 1  287 ? -32.776 0.32    -17.888 1    25.526  ? 323  PHE   A O   1 
ATOM   2337 C  CB  . PHE   A 1  287 ? -30.187 2.374   -17.187 1    22.404  ? 323  PHE   A CB  1 
ATOM   2338 C  CG  . PHE   A 1  287 ? -28.796 2.417   -17.809 1    21.412  ? 323  PHE   A CG  1 
ATOM   2339 C  CD1 . PHE   A 1  287 ? -28.113 1.224   -18.078 1    18.009  ? 323  PHE   A CD1 1 
ATOM   2340 C  CD2 . PHE   A 1  287 ? -28.198 3.638   -18.195 1    20.167  ? 323  PHE   A CD2 1 
ATOM   2341 C  CE1 . PHE   A 1  287 ? -26.849 1.264   -18.721 1    20.644  ? 323  PHE   A CE1 1 
ATOM   2342 C  CE2 . PHE   A 1  287 ? -26.92  3.64    -18.763 1    20.268  ? 323  PHE   A CE2 1 
ATOM   2343 C  CZ  . PHE   A 1  287 ? -26.259 2.448   -19.064 1    17.102  ? 323  PHE   A CZ  1 
ATOM   2344 N  N   . THR   A 1  288 ? -33.332 2.277   -16.845 1    21.6    ? 324  THR   A N   1 
ATOM   2345 C  CA  . THR   A 1  288 ? -34.519 1.654   -16.229 1    23.435  ? 324  THR   A CA  1 
ATOM   2346 C  C   . THR   A 1  288 ? -35.573 1.324   -17.288 1    24.293  ? 324  THR   A C   1 
ATOM   2347 O  O   . THR   A 1  288 ? -36.204 0.266   -17.18  1    25.017  ? 324  THR   A O   1 
ATOM   2348 C  CB  . THR   A 1  288 ? -35.064 2.438   -15.057 1    26.109  ? 324  THR   A CB  1 
ATOM   2349 O  OG1 . THR   A 1  288 ? -35.314 3.666   -15.696 1    26.532  ? 324  THR   A OG1 1 
ATOM   2350 C  CG2 . THR   A 1  288 ? -33.957 2.794   -14.076 1    23.604  ? 324  THR   A CG2 1 
ATOM   2351 N  N   . SER   A 1  289 ? -35.593 2.08    -18.415 1    21.856  ? 325  SER   A N   1 
ATOM   2352 C  CA  . SER   A 1  289 ? -36.495 1.733   -19.517 1    22.443  ? 325  SER   A CA  1 
ATOM   2353 C  C   . SER   A 1  289 ? -36.288 0.296   -19.977 1    25.866  ? 325  SER   A C   1 
ATOM   2354 O  O   . SER   A 1  289 ? -37.241 -0.314  -20.473 1    26.401  ? 325  SER   A O   1 
ATOM   2355 C  CB  . SER   A 1  289 ? -36.471 2.712   -20.712 1    21.731  ? 325  SER   A CB  1 
ATOM   2356 O  OG  . SER   A 1  289 ? -35.467 2.329   -21.655 1    21.639  ? 325  SER   A OG  1 
ATOM   2357 N  N   . LEU   A 1  290 ? -35.025 -0.19   -19.888 1    20.476  ? 326  LEU   A N   1 
ATOM   2358 C  CA  . LEU   A 1  290 ? -34.596 -1.503  -20.367 1    22.25   ? 326  LEU   A CA  1 
ATOM   2359 C  C   . LEU   A 1  290 ? -34.877 -2.585  -19.316 1    23.941  ? 326  LEU   A C   1 
ATOM   2360 O  O   . LEU   A 1  290 ? -34.635 -3.791  -19.585 1    23.418  ? 326  LEU   A O   1 
ATOM   2361 C  CB  . LEU   A 1  290 ? -33.139 -1.549  -20.851 1    20.736  ? 326  LEU   A CB  1 
ATOM   2362 C  CG  . LEU   A 1  290 ? -32.73  -0.576  -21.988 1    20.297  ? 326  LEU   A CG  1 
ATOM   2363 C  CD1 . LEU   A 1  290 ? -31.288 -1.05   -22.382 1    18.114  ? 326  LEU   A CD1 1 
ATOM   2364 C  CD2 . LEU   A 1  290 ? -33.66  -0.692  -23.191 1    20.432  ? 326  LEU   A CD2 1 
ATOM   2365 N  N   . GLY   A 1  291 ? -35.41  -2.104  -18.171 1    22.541  ? 327  GLY   A N   1 
ATOM   2366 C  CA  . GLY   A 1  291 ? -35.598 -2.839  -16.936 1    25.768  ? 327  GLY   A CA  1 
ATOM   2367 C  C   . GLY   A 1  291 ? -34.251 -3.159  -16.279 1    33.799  ? 327  GLY   A C   1 
ATOM   2368 O  O   . GLY   A 1  291 ? -34.217 -4.087  -15.485 1    27.51   ? 327  GLY   A O   1 
ATOM   2369 N  N   . LEU   A 1  292 ? -33.19  -2.367  -16.564 1    24.467  ? 328  LEU   A N   1 
ATOM   2370 C  CA  . LEU   A 1  292 ? -31.914 -2.462  -15.864 1    24.937  ? 328  LEU   A CA  1 
ATOM   2371 C  C   . LEU   A 1  292 ? -32.067 -1.655  -14.561 1    29.572  ? 328  LEU   A C   1 
ATOM   2372 O  O   . LEU   A 1  292 ? -33.114 -0.993  -14.357 1    28.234  ? 328  LEU   A O   1 
ATOM   2373 C  CB  . LEU   A 1  292 ? -30.796 -1.97   -16.812 1    22.086  ? 328  LEU   A CB  1 
ATOM   2374 C  CG  . LEU   A 1  292 ? -30.522 -2.795  -18.101 1    22.756  ? 328  LEU   A CG  1 
ATOM   2375 C  CD1 . LEU   A 1  292 ? -29.468 -2.175  -19.06  1    18.067  ? 328  LEU   A CD1 1 
ATOM   2376 C  CD2 . LEU   A 1  292 ? -30.082 -4.247  -17.79  1    25.089  ? 328  LEU   A CD2 1 
ATOM   2377 N  N   . LEU   A 1  293 ? -31.028 -1.644  -13.715 1    21.232  ? 329  LEU   A N   1 
ATOM   2378 C  CA  . LEU   A 1  293 ? -31.073 -1.069  -12.378 1    19.884  ? 329  LEU   A CA  1 
ATOM   2379 C  C   . LEU   A 1  293 ? -30.976 0.44    -12.364 1    22.08   ? 329  LEU   A C   1 
ATOM   2380 O  O   . LEU   A 1  293 ? -30.198 1.042   -13.081 1    27.762  ? 329  LEU   A O   1 
ATOM   2381 C  CB  . LEU   A 1  293 ? -29.988 -1.638  -11.476 1    21.565  ? 329  LEU   A CB  1 
ATOM   2382 C  CG  . LEU   A 1  293 ? -30.077 -3.156  -11.358 1    26.88   ? 329  LEU   A CG  1 
ATOM   2383 C  CD1 . LEU   A 1  293 ? -28.725 -3.558  -10.793 1    22.27   ? 329  LEU   A CD1 1 
ATOM   2384 C  CD2 . LEU   A 1  293 ? -31.317 -3.411  -10.408 1    28.065  ? 329  LEU   A CD2 1 
ATOM   2385 N  N   . PRO   A 1  294 ? -31.734 1.098   -11.454 1    30.618  ? 330  PRO   A N   1 
ATOM   2386 C  CA  . PRO   A 1  294 ? -31.636 2.554   -11.299 1    25.888  ? 330  PRO   A CA  1 
ATOM   2387 C  C   . PRO   A 1  294 ? -30.405 2.786   -10.442 1    27.443  ? 330  PRO   A C   1 
ATOM   2388 O  O   . PRO   A 1  294 ? -30.017 1.886   -9.674  1    23.331  ? 330  PRO   A O   1 
ATOM   2389 C  CB  . PRO   A 1  294 ? -32.963 2.963   -10.551 1    27.886  ? 330  PRO   A CB  1 
ATOM   2390 C  CG  . PRO   A 1  294 ? -33.321 1.657   -9.812  1    31.97   ? 330  PRO   A CG  1 
ATOM   2391 C  CD  . PRO   A 1  294 ? -32.752 0.448   -10.59  1    28.368  ? 330  PRO   A CD  1 
ATOM   2392 N  N   . VAL   A 1  295 ? -29.804 3.979   -10.543 1    23.329  ? 331  VAL   A N   1 
ATOM   2393 C  CA  . VAL   A 1  295 ? -28.694 4.21    -9.633  1    24.077  ? 331  VAL   A CA  1 
ATOM   2394 C  C   . VAL   A 1  295 ? -29.287 4.537   -8.253  1    27.773  ? 331  VAL   A C   1 
ATOM   2395 O  O   . VAL   A 1  295 ? -30.397 5.072   -8.192  1    26.788  ? 331  VAL   A O   1 
ATOM   2396 C  CB  . VAL   A 1  295 ? -27.763 5.345   -10.114 1    23.213  ? 331  VAL   A CB  1 
ATOM   2397 C  CG1 . VAL   A 1  295 ? -27.077 4.965   -11.433 1    19.897  ? 331  VAL   A CG1 1 
ATOM   2398 C  CG2 . VAL   A 1  295 ? -28.491 6.682   -10.236 1    19.759  ? 331  VAL   A CG2 1 
ATOM   2399 N  N   . PRO   A 1  296 ? -28.615 4.236   -7.117  1    26.445  ? 332  PRO   A N   1 
ATOM   2400 C  CA  . PRO   A 1  296 ? -29.232 4.422   -5.799  1    30.442  ? 332  PRO   A CA  1 
ATOM   2401 C  C   . PRO   A 1  296 ? -29.335 5.896   -5.445  1    31.863  ? 332  PRO   A C   1 
ATOM   2402 O  O   . PRO   A 1  296 ? -28.785 6.758   -6.14   1    29.697  ? 332  PRO   A O   1 
ATOM   2403 C  CB  . PRO   A 1  296 ? -28.33  3.607   -4.797  1    25.69   ? 332  PRO   A CB  1 
ATOM   2404 C  CG  . PRO   A 1  296 ? -27.506 2.735   -5.714  1    26.724  ? 332  PRO   A CG  1 
ATOM   2405 C  CD  . PRO   A 1  296 ? -27.274 3.599   -6.978  1    22.347  ? 332  PRO   A CD  1 
ATOM   2406 N  N   . PRO   A 1  297 ? -30.192 6.237   -4.46   1    34.034  ? 333  PRO   A N   1 
ATOM   2407 C  CA  . PRO   A 1  297 ? -30.255 7.618   -3.974  1    34.046  ? 333  PRO   A CA  1 
ATOM   2408 C  C   . PRO   A 1  297 ? -28.885 8.188   -3.597  1    30.563  ? 333  PRO   A C   1 
ATOM   2409 O  O   . PRO   A 1  297 ? -28.592 9.34    -3.877  1    33.49   ? 333  PRO   A O   1 
ATOM   2410 C  CB  . PRO   A 1  297 ? -31.216 7.467   -2.767  1    31.784  ? 333  PRO   A CB  1 
ATOM   2411 C  CG  . PRO   A 1  297 ? -32.143 6.345   -3.218  1    30.42   ? 333  PRO   A CG  1 
ATOM   2412 C  CD  . PRO   A 1  297 ? -31.162 5.318   -3.81   1    29.003  ? 333  PRO   A CD  1 
ATOM   2413 N  N   . GLU   A 1  298 ? -28     7.352   -3.065  1    29.21   ? 334  GLU   A N   1 
ATOM   2414 C  CA  . GLU   A 1  298 ? -26.697 7.817   -2.612  1    27.854  ? 334  GLU   A CA  1 
ATOM   2415 C  C   . GLU   A 1  298 ? -25.819 8.293   -3.773  1    26.378  ? 334  GLU   A C   1 
ATOM   2416 O  O   . GLU   A 1  298 ? -25.125 9.316   -3.626  1    27.42   ? 334  GLU   A O   1 
ATOM   2417 C  CB  . GLU   A 1  298 ? -26.019 6.582   -2.011  1    35.008  ? 334  GLU   A CB  1 
ATOM   2418 C  CG  . GLU   A 1  298 ? -24.687 6.948   -1.371  1    35.645  ? 334  GLU   A CG  1 
ATOM   2419 C  CD  . GLU   A 1  298 ? -23.928 5.889   -0.554  1    42.204  ? 334  GLU   A CD  1 
ATOM   2420 O  OE1 . GLU   A 1  298 ? -24.234 4.683   -0.627  1    43.22   ? 334  GLU   A OE1 1 
ATOM   2421 O  OE2 . GLU   A 1  298 ? -23.008 6.287   0.188   1    55.263  ? 334  GLU   A OE2 1 
ATOM   2422 N  N   . PHE   A 1  299 ? -26.045 7.678   -4.97   1    26.199  ? 335  PHE   A N   1 
ATOM   2423 C  CA  . PHE   A 1  299 ? -25.416 8.149   -6.207  1    23.239  ? 335  PHE   A CA  1 
ATOM   2424 C  C   . PHE   A 1  299 ? -25.656 9.648   -6.415  1    21.51   ? 335  PHE   A C   1 
ATOM   2425 O  O   . PHE   A 1  299 ? -24.708 10.422  -6.654  1    24.564  ? 335  PHE   A O   1 
ATOM   2426 C  CB  . PHE   A 1  299 ? -25.842 7.322   -7.427  1    22.743  ? 335  PHE   A CB  1 
ATOM   2427 C  CG  . PHE   A 1  299 ? -25.362 7.948   -8.743  1    26.392  ? 335  PHE   A CG  1 
ATOM   2428 C  CD1 . PHE   A 1  299 ? -25.999 9.047   -9.285  1    25.294  ? 335  PHE   A CD1 1 
ATOM   2429 C  CD2 . PHE   A 1  299 ? -24.259 7.438   -9.43   1    23.336  ? 335  PHE   A CD2 1 
ATOM   2430 C  CE1 . PHE   A 1  299 ? -25.574 9.647   -10.465 1    25.804  ? 335  PHE   A CE1 1 
ATOM   2431 C  CE2 . PHE   A 1  299 ? -23.868 8.003   -10.638 1    23.566  ? 335  PHE   A CE2 1 
ATOM   2432 C  CZ  . PHE   A 1  299 ? -24.551 9.063   -11.196 1    23.235  ? 335  PHE   A CZ  1 
ATOM   2433 N  N   . TRP   A 1  300 ? -26.909 10.082  -6.257  1    23.065  ? 336  TRP   A N   1 
ATOM   2434 C  CA  . TRP   A 1  300 ? -27.244 11.487  -6.52   1    22.193  ? 336  TRP   A CA  1 
ATOM   2435 C  C   . TRP   A 1  300 ? -26.726 12.443  -5.446  1    24.216  ? 336  TRP   A C   1 
ATOM   2436 O  O   . TRP   A 1  300 ? -26.429 13.603  -5.732  1    24.151  ? 336  TRP   A O   1 
ATOM   2437 C  CB  . TRP   A 1  300 ? -28.765 11.679  -6.65   1    24.086  ? 336  TRP   A CB  1 
ATOM   2438 C  CG  . TRP   A 1  300 ? -29.38  10.856  -7.733  1    25.912  ? 336  TRP   A CG  1 
ATOM   2439 C  CD1 . TRP   A 1  300 ? -30.162 9.752   -7.62   1    26.296  ? 336  TRP   A CD1 1 
ATOM   2440 C  CD2 . TRP   A 1  300 ? -29.213 11.108  -9.152  1    25.304  ? 336  TRP   A CD2 1 
ATOM   2441 N  NE1 . TRP   A 1  300 ? -30.495 9.294   -8.874  1    25.936  ? 336  TRP   A NE1 1 
ATOM   2442 C  CE2 . TRP   A 1  300 ? -29.929 10.102  -9.824  1    27.1    ? 336  TRP   A CE2 1 
ATOM   2443 C  CE3 . TRP   A 1  300 ? -28.525 12.085  -9.905  1    26.452  ? 336  TRP   A CE3 1 
ATOM   2444 C  CZ2 . TRP   A 1  300 ? -29.969 10.027  -11.223 1    26.5    ? 336  TRP   A CZ2 1 
ATOM   2445 C  CZ3 . TRP   A 1  300 ? -28.592 12.025  -11.306 1    24.273  ? 336  TRP   A CZ3 1 
ATOM   2446 C  CH2 . TRP   A 1  300 ? -29.317 11.014  -11.945 1    25.738  ? 336  TRP   A CH2 1 
ATOM   2447 N  N   . GLN   A 1  301 ? -26.567 11.976  -4.212  1    29.428  ? 337  GLN   A N   1 
ATOM   2448 C  CA  . GLN   A 1  301 ? -26.054 12.833  -3.141  1    30.996  ? 337  GLN   A CA  1 
ATOM   2449 C  C   . GLN   A 1  301 ? -24.533 12.935  -3.169  1    29.514  ? 337  GLN   A C   1 
ATOM   2450 O  O   . GLN   A 1  301 ? -24.031 13.978  -2.774  1    29.22   ? 337  GLN   A O   1 
ATOM   2451 C  CB  . GLN   A 1  301 ? -26.202 12.163  -1.766  1    36.603  ? 337  GLN   A CB  1 
ATOM   2452 C  CG  . GLN   A 1  301 ? -27.64  12.112  -1.278  1    61.395  ? 337  GLN   A CG  1 
ATOM   2453 C  CD  . GLN   A 1  301 ? -27.861 11.093  -0.181  1    80.106  ? 337  GLN   A CD  1 
ATOM   2454 O  OE1 . GLN   A 1  301 ? -27.031 10.927  0.726   1    85.221  ? 337  GLN   A OE1 1 
ATOM   2455 N  NE2 . GLN   A 1  301 ? -28.99  10.395  -0.269  1    78.606  ? 337  GLN   A NE2 1 
ATOM   2456 N  N   . LYS   A 1  302 ? -23.809 11.854  -3.592  1    25.57   ? 338  LYS   A N   1 
ATOM   2457 C  CA  . LYS   A 1  302 ? -22.358 11.855  -3.519  1    26.393  ? 338  LYS   A CA  1 
ATOM   2458 C  C   . LYS   A 1  302 ? -21.648 12.176  -4.841  1    24.843  ? 338  LYS   A C   1 
ATOM   2459 O  O   . LYS   A 1  302 ? -20.464 12.524  -4.795  1    25.159  ? 338  LYS   A O   1 
ATOM   2460 C  CB  . LYS   A 1  302 ? -21.834 10.527  -2.953  1    30.963  ? 338  LYS   A CB  1 
ATOM   2461 C  CG  . LYS   A 1  302 ? -22.448 10.332  -1.592  1    32.73   ? 338  LYS   A CG  1 
ATOM   2462 C  CD  . LYS   A 1  302 ? -21.679 9.288   -0.823  1    36.064  ? 338  LYS   A CD  1 
ATOM   2463 C  CE  . LYS   A 1  302 ? -22.191 9.356   0.597   1    52.139  ? 338  LYS   A CE  1 
ATOM   2464 N  NZ  . LYS   A 1  302 ? -21.571 8.323   1.428   1    55.561  ? 338  LYS   A NZ  1 
ATOM   2465 N  N   . SER   A 1  303 ? -22.305 12.039  -6.006  1    24.277  ? 339  SER   A N   1 
ATOM   2466 C  CA  . SER   A 1  303 ? -21.527 12.17   -7.264  1    22.146  ? 339  SER   A CA  1 
ATOM   2467 C  C   . SER   A 1  303 ? -21.101 13.615  -7.444  1    25.302  ? 339  SER   A C   1 
ATOM   2468 O  O   . SER   A 1  303 ? -21.677 14.458  -6.842  1    26.339  ? 339  SER   A O   1 
ATOM   2469 C  CB  . SER   A 1  303 ? -22.319 11.752  -8.455  1    20.225  ? 339  SER   A CB  1 
ATOM   2470 O  OG  . SER   A 1  303 ? -22.518 10.332  -8.386  1    21.634  ? 339  SER   A OG  1 
ATOM   2471 N  N   . MET   A 1  304 ? -20.09  13.914  -8.236  1    22.397  ? 340  MET   A N   1 
ATOM   2472 C  CA  . MET   A 1  304 ? -19.744 15.292  -8.561  1    22.17   ? 340  MET   A CA  1 
ATOM   2473 C  C   . MET   A 1  304 ? -20.035 15.43   -10.066 1    28.94   ? 340  MET   A C   1 
ATOM   2474 O  O   . MET   A 1  304 ? -19.255 14.906  -10.886 1    23.123  ? 340  MET   A O   1 
ATOM   2475 C  CB  . MET   A 1  304 ? -18.246 15.532  -8.305  1    22.131  ? 340  MET   A CB  1 
ATOM   2476 C  CG  . MET   A 1  304 ? -17.818 17      -8.548  1    24.4    ? 340  MET   A CG  1 
ATOM   2477 S  SD  . MET   A 1  304 ? -16.042 17.134  -8.889  1    27.383  ? 340  MET   A SD  1 
ATOM   2478 C  CE  . MET   A 1  304 ? -15.959 16.936  -10.66  1    26.306  ? 340  MET   A CE  1 
ATOM   2479 N  N   . LEU   A 1  305 ? -21.173 16.102  -10.424 1    26.314  ? 341  LEU   A N   1 
ATOM   2480 C  CA  . LEU   A 1  305 ? -21.694 16.1    -11.789 1    24.728  ? 341  LEU   A CA  1 
ATOM   2481 C  C   . LEU   A 1  305 ? -21.399 17.411  -12.535 1    29.03   ? 341  LEU   A C   1 
ATOM   2482 O  O   . LEU   A 1  305 ? -21.743 17.597  -13.721 1    28.45   ? 341  LEU   A O   1 
ATOM   2483 C  CB  . LEU   A 1  305 ? -23.174 15.653  -11.815 1    22.816  ? 341  LEU   A CB  1 
ATOM   2484 C  CG  . LEU   A 1  305 ? -23.443 14.28   -11.188 1    22.786  ? 341  LEU   A CG  1 
ATOM   2485 C  CD1 . LEU   A 1  305 ? -24.932 14.031  -11.266 1    22.73   ? 341  LEU   A CD1 1 
ATOM   2486 C  CD2 . LEU   A 1  305 ? -22.74  13.061  -11.834 1    24.471  ? 341  LEU   A CD2 1 
ATOM   2487 N  N   . GLU   A 1  306 ? -20.716 18.318  -11.862 1    23.686  ? 342  GLU   A N   1 
ATOM   2488 C  CA  . GLU   A 1  306 ? -20.284 19.511  -12.554 1    28.552  ? 342  GLU   A CA  1 
ATOM   2489 C  C   . GLU   A 1  306 ? -18.998 19.941  -11.887 1    29.568  ? 342  GLU   A C   1 
ATOM   2490 O  O   . GLU   A 1  306 ? -18.716 19.578  -10.733 1    29.748  ? 342  GLU   A O   1 
ATOM   2491 C  CB  . GLU   A 1  306 ? -21.175 20.756  -12.552 1    31.986  ? 342  GLU   A CB  1 
ATOM   2492 C  CG  . GLU   A 1  306 ? -21.705 21.166  -11.178 1    44.918  ? 342  GLU   A CG  1 
ATOM   2493 C  CD  . GLU   A 1  306 ? -23.18  20.791  -11.077 1    58.558  ? 342  GLU   A CD  1 
ATOM   2494 O  OE1 . GLU   A 1  306 ? -23.965 21.488  -11.775 1    60.123  ? 342  GLU   A OE1 1 
ATOM   2495 O  OE2 . GLU   A 1  306 ? -23.53  19.793  -10.395 1    55.255  ? 342  GLU   A OE2 1 
ATOM   2496 N  N   . LYS   A 1  307 ? -18.254 20.769  -12.609 1    26.653  ? 343  LYS   A N   1 
ATOM   2497 C  CA  . LYS   A 1  307 ? -16.983 21.257  -12.13  1    26.884  ? 343  LYS   A CA  1 
ATOM   2498 C  C   . LYS   A 1  307 ? -17.218 22.171  -10.925 1    37.497  ? 343  LYS   A C   1 
ATOM   2499 O  O   . LYS   A 1  307 ? -18.05  23.057  -11.032 1    31.813  ? 343  LYS   A O   1 
ATOM   2500 C  CB  . LYS   A 1  307 ? -16.293 22.029  -13.249 1    27.653  ? 343  LYS   A CB  1 
ATOM   2501 C  CG  . LYS   A 1  307 ? -14.907 22.394  -12.691 1    29.57   ? 343  LYS   A CG  1 
ATOM   2502 C  CD  . LYS   A 1  307 ? -14.538 23.612  -13.512 1    39.901  ? 343  LYS   A CD  1 
ATOM   2503 C  CE  . LYS   A 1  307 ? -13.847 23.285  -14.747 1    37.142  ? 343  LYS   A CE  1 
ATOM   2504 N  NZ  . LYS   A 1  307 ? -12.486 23.76   -14.573 1    41.123  ? 343  LYS   A NZ  1 
ATOM   2505 N  N   . PRO   A 1  308 ? -16.577 21.936  -9.752  1    38.131  ? 344  PRO   A N   1 
ATOM   2506 C  CA  . PRO   A 1  308 ? -16.704 22.833  -8.59   1    38.173  ? 344  PRO   A CA  1 
ATOM   2507 C  C   . PRO   A 1  308 ? -16.458 24.295  -8.948  1    34.039  ? 344  PRO   A C   1 
ATOM   2508 O  O   . PRO   A 1  308 ? -15.581 24.646  -9.736  1    35.197  ? 344  PRO   A O   1 
ATOM   2509 C  CB  . PRO   A 1  308 ? -15.572 22.312  -7.677  1    41.052  ? 344  PRO   A CB  1 
ATOM   2510 C  CG  . PRO   A 1  308 ? -15.586 20.818  -7.986  1    36.83   ? 344  PRO   A CG  1 
ATOM   2511 C  CD  . PRO   A 1  308 ? -15.76  20.734  -9.488  1    33.875  ? 344  PRO   A CD  1 
ATOM   2512 N  N   . THR   A 1  309 ? -17.165 25.188  -8.289  1    41.708  ? 345  THR   A N   1 
ATOM   2513 C  CA  . THR   A 1  309 ? -16.946 26.601  -8.584  1    44.94   ? 345  THR   A CA  1 
ATOM   2514 C  C   . THR   A 1  309 ? -16.093 27.273  -7.504  1    57.51   ? 345  THR   A C   1 
ATOM   2515 O  O   . THR   A 1  309 ? -15.828 28.457  -7.619  1    64.748  ? 345  THR   A O   1 
ATOM   2516 C  CB  . THR   A 1  309 ? -18.29  27.288  -8.834  1    42.303  ? 345  THR   A CB  1 
ATOM   2517 O  OG1 . THR   A 1  309 ? -19.183 26.877  -7.785  1    40.264  ? 345  THR   A OG1 1 
ATOM   2518 C  CG2 . THR   A 1  309 ? -18.821 26.891  -10.201 1    40.056  ? 345  THR   A CG2 1 
ATOM   2519 N  N   . ASP   A 1  310 ? -15.618 26.518  -6.496  1    62.936  ? 346  ASP   A N   1 
ATOM   2520 C  CA  . ASP   A 1  310 ? -14.85  27.051  -5.368  1    59.09   ? 346  ASP   A CA  1 
ATOM   2521 C  C   . ASP   A 1  310 ? -13.341 27.169  -5.668  1    59.553  ? 346  ASP   A C   1 
ATOM   2522 O  O   . ASP   A 1  310 ? -12.555 27.317  -4.743  1    51.53   ? 346  ASP   A O   1 
ATOM   2523 C  CB  . ASP   A 1  310 ? -15.117 26.261  -4.095  1    48.304  ? 346  ASP   A CB  1 
ATOM   2524 C  CG  . ASP   A 1  310 ? -14.688 24.796  -4.196  1    65.012  ? 346  ASP   A CG  1 
ATOM   2525 O  OD1 . ASP   A 1  310 ? -13.967 24.454  -5.168  1    72.745  ? 346  ASP   A OD1 1 
ATOM   2526 O  OD2 . ASP   A 1  310 ? -15.08  23.984  -3.332  1    52.546  ? 346  ASP   A OD2 1 
ATOM   2527 N  N   . GLY   A 1  311 ? -12.912 27.134  -6.944  1    68.585  ? 347  GLY   A N   1 
ATOM   2528 C  CA  . GLY   A 1  311 ? -11.505 27.351  -7.274  1    65.146  ? 347  GLY   A CA  1 
ATOM   2529 C  C   . GLY   A 1  311 ? -10.58  26.158  -6.968  1    72.655  ? 347  GLY   A C   1 
ATOM   2530 O  O   . GLY   A 1  311 ? -9.441  26.177  -7.442  1    63.513  ? 347  GLY   A O   1 
ATOM   2531 N  N   . ARG   A 1  312 ? -11.06  25.166  -6.165  1    64.925  ? 348  ARG   A N   1 
ATOM   2532 C  CA  . ARG   A 1  312 ? -10.512 23.82   -5.935  1    50.512  ? 348  ARG   A CA  1 
ATOM   2533 C  C   . ARG   A 1  312 ? -9.986  23.164  -7.219  1    49.914  ? 348  ARG   A C   1 
ATOM   2534 O  O   . ARG   A 1  312 ? -10.55  23.326  -8.289  1    50.416  ? 348  ARG   A O   1 
ATOM   2535 C  CB  . ARG   A 1  312 ? -11.607 23.038  -5.199  1    41.645  ? 348  ARG   A CB  1 
ATOM   2536 C  CG  . ARG   A 1  312 ? -11.971 21.608  -5.536  1    47.547  ? 348  ARG   A CG  1 
ATOM   2537 C  CD  . ARG   A 1  312 ? -12.604 20.989  -4.292  1    44.471  ? 348  ARG   A CD  1 
ATOM   2538 N  NE  . ARG   A 1  312 ? -13.991 21.391  -4.055  1    51.76   ? 348  ARG   A NE  1 
ATOM   2539 C  CZ  . ARG   A 1  312 ? -15.082 20.671  -4.267  1    50.364  ? 348  ARG   A CZ  1 
ATOM   2540 N  NH1 . ARG   A 1  312 ? -15.062 19.477  -4.805  1    38.871  ? 348  ARG   A NH1 1 
ATOM   2541 N  NH2 . ARG   A 1  312 ? -16.251 21.171  -3.985  1    64.961  ? 348  ARG   A NH2 1 
ATOM   2542 N  N   . GLU   A 1  313 ? -8.833  22.497  -7.163  1    42.128  ? 349  GLU   A N   1 
ATOM   2543 C  CA  . GLU   A 1  313 ? -8.409  21.722  -8.32   1    38.02   ? 349  GLU   A CA  1 
ATOM   2544 C  C   . GLU   A 1  313 ? -9.072  20.33   -8.263  1    39.334  ? 349  GLU   A C   1 
ATOM   2545 O  O   . GLU   A 1  313 ? -8.994  19.627  -7.249  1    31.572  ? 349  GLU   A O   1 
ATOM   2546 C  CB  . GLU   A 1  313 ? -6.884  21.703  -8.238  1    45.344  ? 349  GLU   A CB  1 
ATOM   2547 C  CG  . GLU   A 1  313 ? -6.208  23.067  -8.344  1    52.318  ? 349  GLU   A CG  1 
ATOM   2548 C  CD  . GLU   A 1  313 ? -5.803  23.529  -9.743  1    58.034  ? 349  GLU   A CD  1 
ATOM   2549 O  OE1 . GLU   A 1  313 ? -5.053  24.518  -9.765  1    69.087  ? 349  GLU   A OE1 1 
ATOM   2550 O  OE2 . GLU   A 1  313 ? -6.208  22.99   -10.805 1    50.475  ? 349  GLU   A OE2 1 
ATOM   2551 N  N   . VAL   A 1  314 ? -9.778  19.925  -9.333  1    36.774  ? 350  VAL   A N   1 
ATOM   2552 C  CA  . VAL   A 1  314 ? -10.301 18.577  -9.459  1    24.598  ? 350  VAL   A CA  1 
ATOM   2553 C  C   . VAL   A 1  314 ? -9.633  17.894  -10.664 1    24.395  ? 350  VAL   A C   1 
ATOM   2554 O  O   . VAL   A 1  314 ? -9.039  18.547  -11.541 1    22.837  ? 350  VAL   A O   1 
ATOM   2555 C  CB  . VAL   A 1  314 ? -11.844 18.547  -9.574  1    27.58   ? 350  VAL   A CB  1 
ATOM   2556 C  CG1 . VAL   A 1  314 ? -12.579 19.166  -8.365  1    29.041  ? 350  VAL   A CG1 1 
ATOM   2557 C  CG2 . VAL   A 1  314 ? -12.324 19.219  -10.866 1    26.983  ? 350  VAL   A CG2 1 
ATOM   2558 N  N   . VAL   A 1  315 ? -9.741  16.558  -10.691 1    21.913  ? 351  VAL   A N   1 
ATOM   2559 C  CA  . VAL   A 1  315 ? -9.524  15.794  -11.897 1    22.425  ? 351  VAL   A CA  1 
ATOM   2560 C  C   . VAL   A 1  315 ? -10.831 15.906  -12.671 1    22.431  ? 351  VAL   A C   1 
ATOM   2561 O  O   . VAL   A 1  315 ? -11.834 15.326  -12.242 1    23.206  ? 351  VAL   A O   1 
ATOM   2562 C  CB  . VAL   A 1  315 ? -9.136  14.336  -11.632 1    23.432  ? 351  VAL   A CB  1 
ATOM   2563 C  CG1 . VAL   A 1  315 ? -8.955  13.588  -12.957 1    19.334  ? 351  VAL   A CG1 1 
ATOM   2564 C  CG2 . VAL   A 1  315 ? -7.829  14.335  -10.845 1    23.876  ? 351  VAL   A CG2 1 
ATOM   2565 N  N   . CYS   A 1  316 ? -10.818 16.681  -13.778 1    20.836  ? 352  CYS   A N   1 
ATOM   2566 C  CA  . CYS   A 1  316 ? -12.063 16.892  -14.531 1    26.45   ? 352  CYS   A CA  1 
ATOM   2567 C  C   . CYS   A 1  316 ? -12.454 15.701  -15.414 1    25.593  ? 352  CYS   A C   1 
ATOM   2568 O  O   . CYS   A 1  316 ? -13.634 15.509  -15.719 1    25.215  ? 352  CYS   A O   1 
ATOM   2569 C  CB  . CYS   A 1  316 ? -12.029 18.162  -15.368 1    26.952  ? 352  CYS   A CB  1 
ATOM   2570 S  SG  . CYS   A 1  316 ? -12.833 19.499  -14.441 1    30.319  ? 352  CYS   A SG  1 
ATOM   2571 N  N   . HIS   A 1  317 ? -11.462 14.924  -15.837 1    20.576  ? 353  HIS   A N   1 
ATOM   2572 C  CA  . HIS   A 1  317 ? -11.725 13.84   -16.754 1    23.108  ? 353  HIS   A CA  1 
ATOM   2573 C  C   . HIS   A 1  317 ? -12.823 12.932  -16.193 1    22.38   ? 353  HIS   A C   1 
ATOM   2574 O  O   . HIS   A 1  317 ? -12.699 12.417  -15.097 1    19.832  ? 353  HIS   A O   1 
ATOM   2575 C  CB  . HIS   A 1  317 ? -10.412 13.104  -17.069 1    19.649  ? 353  HIS   A CB  1 
ATOM   2576 C  CG  . HIS   A 1  317 ? -10.587 12.155  -18.234 1    17.999  ? 353  HIS   A CG  1 
ATOM   2577 N  ND1 . HIS   A 1  317 ? -10.183 12.368  -19.547 1    19.395  ? 353  HIS   A ND1 1 
ATOM   2578 C  CD2 . HIS   A 1  317 ? -11.15  10.956  -18.213 1    21.496  ? 353  HIS   A CD2 1 
ATOM   2579 C  CE1 . HIS   A 1  317 ? -10.528 11.329  -20.306 1    19.15   ? 353  HIS   A CE1 1 
ATOM   2580 N  NE2 . HIS   A 1  317 ? -11.069 10.424  -19.479 1    22.797  ? 353  HIS   A NE2 1 
ATOM   2581 N  N   . ALA   A 1  318 ? -13.883 12.701  -16.968 1    19.983  ? 354  ALA   A N   1 
ATOM   2582 C  CA  . ALA   A 1  318 ? -15.033 11.902  -16.515 1    19.97   ? 354  ALA   A CA  1 
ATOM   2583 C  C   . ALA   A 1  318 ? -14.609 10.49   -16.099 1    18.834  ? 354  ALA   A C   1 
ATOM   2584 O  O   . ALA   A 1  318 ? -13.917 9.808   -16.87  1    18.567  ? 354  ALA   A O   1 
ATOM   2585 C  CB  . ALA   A 1  318 ? -16.085 11.798  -17.622 1    19.321  ? 354  ALA   A CB  1 
ATOM   2586 N  N   . SER   A 1  319 ? -15.191 10.03   -14.955 1    17.808  ? 355  SER   A N   1 
ATOM   2587 C  CA  . SER   A 1  319 ? -14.906 8.683   -14.464 1    20.276  ? 355  SER   A CA  1 
ATOM   2588 C  C   . SER   A 1  319 ? -16.039 8.182   -13.567 1    19.014  ? 355  SER   A C   1 
ATOM   2589 O  O   . SER   A 1  319 ? -16.808 8.978   -13.003 1    18.227  ? 355  SER   A O   1 
ATOM   2590 C  CB  . SER   A 1  319 ? -13.509 8.583   -13.819 1    17.948  ? 355  SER   A CB  1 
ATOM   2591 O  OG  . SER   A 1  319 ? -13.41  9.566   -12.777 1    21.35   ? 355  SER   A OG  1 
ATOM   2592 N  N   . ALA   A 1  320 ? -16.166 6.848   -13.528 1    15.484  ? 356  ALA   A N   1 
ATOM   2593 C  CA  . ALA   A 1  320 ? -17.176 6.133   -12.773 1    18.308  ? 356  ALA   A CA  1 
ATOM   2594 C  C   . ALA   A 1  320 ? -16.456 5.451   -11.621 1    19.691  ? 356  ALA   A C   1 
ATOM   2595 O  O   . ALA   A 1  320 ? -15.328 4.943   -11.813 1    20.041  ? 356  ALA   A O   1 
ATOM   2596 C  CB  . ALA   A 1  320 ? -17.889 5.094   -13.655 1    14.333  ? 356  ALA   A CB  1 
ATOM   2597 N  N   . TRP   A 1  321 ? -17.15  5.377   -10.486 1    21.259  ? 357  TRP   A N   1 
ATOM   2598 C  CA  . TRP   A 1  321 ? -16.511 4.933   -9.249  1    21.742  ? 357  TRP   A CA  1 
ATOM   2599 C  C   . TRP   A 1  321 ? -17.344 3.861   -8.531  1    19.068  ? 357  TRP   A C   1 
ATOM   2600 O  O   . TRP   A 1  321 ? -18.516 4.088   -8.285  1    21.495  ? 357  TRP   A O   1 
ATOM   2601 C  CB  . TRP   A 1  321 ? -16.301 6.164   -8.353  1    18.975  ? 357  TRP   A CB  1 
ATOM   2602 C  CG  . TRP   A 1  321 ? -15.296 7.146   -8.923  1    21.381  ? 357  TRP   A CG  1 
ATOM   2603 C  CD1 . TRP   A 1  321 ? -15.415 7.97    -10.016 1    24.174  ? 357  TRP   A CD1 1 
ATOM   2604 C  CD2 . TRP   A 1  321 ? -13.959 7.367   -8.417  1    23.726  ? 357  TRP   A CD2 1 
ATOM   2605 N  NE1 . TRP   A 1  321 ? -14.229 8.648   -10.25  1    22.769  ? 357  TRP   A NE1 1 
ATOM   2606 C  CE2 . TRP   A 1  321 ? -13.326 8.309   -9.268  1    22.972  ? 357  TRP   A CE2 1 
ATOM   2607 C  CE3 . TRP   A 1  321 ? -13.248 6.852   -7.323  1    22.621  ? 357  TRP   A CE3 1 
ATOM   2608 C  CZ2 . TRP   A 1  321 ? -12.013 8.725   -9.056  1    25.472  ? 357  TRP   A CZ2 1 
ATOM   2609 C  CZ3 . TRP   A 1  321 ? -11.967 7.303   -7.094  1    23.113  ? 357  TRP   A CZ3 1 
ATOM   2610 C  CH2 . TRP   A 1  321 ? -11.332 8.182   -7.979  1    23.339  ? 357  TRP   A CH2 1 
ATOM   2611 N  N   . ASP   A 1  322 ? -16.756 2.667   -8.331  1    17.068  ? 358  ASP   A N   1 
ATOM   2612 C  CA  . ASP   A 1  322 ? -17.234 1.585   -7.463  1    19.022  ? 358  ASP   A CA  1 
ATOM   2613 C  C   . ASP   A 1  322 ? -16.451 1.661   -6.135  1    21.573  ? 358  ASP   A C   1 
ATOM   2614 O  O   . ASP   A 1  322 ? -15.183 1.618   -6.113  1    20.187  ? 358  ASP   A O   1 
ATOM   2615 C  CB  . ASP   A 1  322 ? -16.962 0.287   -8.201  1    19.357  ? 358  ASP   A CB  1 
ATOM   2616 C  CG  . ASP   A 1  322 ? -17.593 -0.944  -7.586  1    22.069  ? 358  ASP   A CG  1 
ATOM   2617 O  OD1 . ASP   A 1  322 ? -18.087 -0.775  -6.46   1    23.02   ? 358  ASP   A OD1 1 
ATOM   2618 O  OD2 . ASP   A 1  322 ? -17.596 -2.042  -8.227  1    23.686  ? 358  ASP   A OD2 1 
ATOM   2619 N  N   . PHE   A 1  323 ? -17.191 1.758   -5.022  1    21.16   ? 359  PHE   A N   1 
ATOM   2620 C  CA  . PHE   A 1  323 ? -16.605 1.881   -3.689  1    20.346  ? 359  PHE   A CA  1 
ATOM   2621 C  C   . PHE   A 1  323 ? -16.528 0.51    -3.041  1    24.546  ? 359  PHE   A C   1 
ATOM   2622 O  O   . PHE   A 1  323 ? -16.153 0.425   -1.871  1    26.446  ? 359  PHE   A O   1 
ATOM   2623 C  CB  . PHE   A 1  323 ? -17.236 2.948   -2.79   1    20.96   ? 359  PHE   A CB  1 
ATOM   2624 C  CG  . PHE   A 1  323 ? -16.856 4.327   -3.309  1    23.029  ? 359  PHE   A CG  1 
ATOM   2625 C  CD1 . PHE   A 1  323 ? -17.489 4.868   -4.423  1    26.314  ? 359  PHE   A CD1 1 
ATOM   2626 C  CD2 . PHE   A 1  323 ? -15.854 5.067   -2.694  1    28.593  ? 359  PHE   A CD2 1 
ATOM   2627 C  CE1 . PHE   A 1  323 ? -17.125 6.106   -4.919  1    23.45   ? 359  PHE   A CE1 1 
ATOM   2628 C  CE2 . PHE   A 1  323 ? -15.465 6.311   -3.213  1    26.512  ? 359  PHE   A CE2 1 
ATOM   2629 C  CZ  . PHE   A 1  323 ? -16.101 6.831   -4.312  1    26.038  ? 359  PHE   A CZ  1 
ATOM   2630 N  N   . TYR   A 1  324 ? -16.884 -0.534  -3.807  1    18.612  ? 360  TYR   A N   1 
ATOM   2631 C  CA  . TYR   A 1  324 ? -16.677 -1.921  -3.39   1    26.405  ? 360  TYR   A CA  1 
ATOM   2632 C  C   . TYR   A 1  324 ? -17.49  -2.321  -2.157  1    30.642  ? 360  TYR   A C   1 
ATOM   2633 O  O   . TYR   A 1  324 ? -17.06  -3.193  -1.403  1    38.119  ? 360  TYR   A O   1 
ATOM   2634 C  CB  . TYR   A 1  324 ? -15.184 -2.205  -3.151  1    29.933  ? 360  TYR   A CB  1 
ATOM   2635 C  CG  . TYR   A 1  324 ? -14.5   -2.249  -4.501  1    37.433  ? 360  TYR   A CG  1 
ATOM   2636 C  CD1 . TYR   A 1  324 ? -14.834 -3.298  -5.359  1    53.593  ? 360  TYR   A CD1 1 
ATOM   2637 C  CD2 . TYR   A 1  324 ? -13.715 -1.2    -4.973  1    37.455  ? 360  TYR   A CD2 1 
ATOM   2638 C  CE1 . TYR   A 1  324 ? -14.323 -3.376  -6.639  1    52.142  ? 360  TYR   A CE1 1 
ATOM   2639 C  CE2 . TYR   A 1  324 ? -13.162 -1.278  -6.244  1    37.598  ? 360  TYR   A CE2 1 
ATOM   2640 C  CZ  . TYR   A 1  324 ? -13.498 -2.348  -7.074  1    52.08   ? 360  TYR   A CZ  1 
ATOM   2641 O  OH  . TYR   A 1  324 ? -13.046 -2.497  -8.352  1    62.099  ? 360  TYR   A OH  1 
ATOM   2642 N  N   . ASN   A 1  325 ? -18.664 -1.727  -1.944  1    30.129  ? 361  ASN   A N   1 
ATOM   2643 C  CA  . ASN   A 1  325 ? -19.459 -2.12   -0.799  1    27.204  ? 361  ASN   A CA  1 
ATOM   2644 C  C   . ASN   A 1  325 ? -20.835 -2.515  -1.27   1    25.053  ? 361  ASN   A C   1 
ATOM   2645 O  O   . ASN   A 1  325 ? -21.685 -2.647  -0.443  1    26.785  ? 361  ASN   A O   1 
ATOM   2646 C  CB  . ASN   A 1  325 ? -19.489 -1.056  0.297   1    25.427  ? 361  ASN   A CB  1 
ATOM   2647 C  CG  . ASN   A 1  325 ? -20.228 0.197   -0.099  1    32.098  ? 361  ASN   A CG  1 
ATOM   2648 O  OD1 . ASN   A 1  325 ? -20.762 0.354   -1.206  1    29.894  ? 361  ASN   A OD1 1 
ATOM   2649 N  ND2 . ASN   A 1  325 ? -20.227 1.13    0.825   1    30.233  ? 361  ASN   A ND2 1 
ATOM   2650 N  N   . GLY   A 1  326 ? -21.053 -2.599  -2.591  1    22.61   ? 362  GLY   A N   1 
ATOM   2651 C  CA  . GLY   A 1  326 ? -22.342 -2.897  -3.157  1    22.447  ? 362  GLY   A CA  1 
ATOM   2652 C  C   . GLY   A 1  326 ? -23.408 -1.816  -2.964  1    22.087  ? 362  GLY   A C   1 
ATOM   2653 O  O   . GLY   A 1  326 ? -24.564 -2.03   -3.405  1    26.782  ? 362  GLY   A O   1 
ATOM   2654 N  N   . LYS   A 1  327 ? -23.02  -0.602  -2.515  1    24.415  ? 363  LYS   A N   1 
ATOM   2655 C  CA  . LYS   A 1  327 ? -24.099 0.38    -2.377  1    26.265  ? 363  LYS   A CA  1 
ATOM   2656 C  C   . LYS   A 1  327 ? -23.731 1.783   -2.871  1    24.927  ? 363  LYS   A C   1 
ATOM   2657 O  O   . LYS   A 1  327 ? -24.612 2.543   -3.27   1    29.971  ? 363  LYS   A O   1 
ATOM   2658 C  CB  . LYS   A 1  327 ? -24.326 0.538   -0.861  1    30.357  ? 363  LYS   A CB  1 
ATOM   2659 C  CG  . LYS   A 1  327 ? -24.963 -0.752  -0.355  1    35.421  ? 363  LYS   A CG  1 
ATOM   2660 C  CD  . LYS   A 1  327 ? -25.053 -0.878  1.156   1    47.815  ? 363  LYS   A CD  1 
ATOM   2661 C  CE  . LYS   A 1  327 ? -25.953 -2.081  1.347   1    55.217  ? 363  LYS   A CE  1 
ATOM   2662 N  NZ  . LYS   A 1  327 ? -25.498 -2.936  2.457   1    72.023  ? 363  LYS   A NZ  1 
ATOM   2663 N  N   . ASP   A 1  328 ? -22.446 2.125   -2.738  1    23.927  ? 364  ASP   A N   1 
ATOM   2664 C  CA  . ASP   A 1  328 ? -21.851 3.418   -3.026  1    24.458  ? 364  ASP   A CA  1 
ATOM   2665 C  C   . ASP   A 1  328 ? -21.18  3.374   -4.421  1    22.015  ? 364  ASP   A C   1 
ATOM   2666 O  O   . ASP   A 1  328 ? -20.172 2.698   -4.672  1    22.252  ? 364  ASP   A O   1 
ATOM   2667 C  CB  . ASP   A 1  328 ? -20.978 3.828   -1.854  1    20.058  ? 364  ASP   A CB  1 
ATOM   2668 C  CG  . ASP   A 1  328 ? -20.438 5.26    -1.945  1    28.197  ? 364  ASP   A CG  1 
ATOM   2669 O  OD1 . ASP   A 1  328 ? -20.687 5.961   -2.961  1    23.031  ? 364  ASP   A OD1 1 
ATOM   2670 O  OD2 . ASP   A 1  328 ? -19.695 5.662   -1.06   1    25.599  ? 364  ASP   A OD2 1 
ATOM   2671 N  N   . PHE   A 1  329 ? -21.846 4.009   -5.381  1    24.886  ? 365  PHE   A N   1 
ATOM   2672 C  CA  . PHE   A 1  329 ? -21.373 4.105   -6.766  1    23.382  ? 365  PHE   A CA  1 
ATOM   2673 C  C   . PHE   A 1  329 ? -21.5   5.571   -7.137  1    22.758  ? 365  PHE   A C   1 
ATOM   2674 O  O   . PHE   A 1  329 ? -22.468 6.232   -6.715  1    23.142  ? 365  PHE   A O   1 
ATOM   2675 C  CB  . PHE   A 1  329 ? -22.158 3.293   -7.799  1    22.444  ? 365  PHE   A CB  1 
ATOM   2676 C  CG  . PHE   A 1  329 ? -22.459 1.89    -7.289  1    24.995  ? 365  PHE   A CG  1 
ATOM   2677 C  CD1 . PHE   A 1  329 ? -21.519 0.849   -7.408  1    23.808  ? 365  PHE   A CD1 1 
ATOM   2678 C  CD2 . PHE   A 1  329 ? -23.687 1.595   -6.715  1    27.325  ? 365  PHE   A CD2 1 
ATOM   2679 C  CE1 . PHE   A 1  329 ? -21.804 -0.456  -6.972  1    23.268  ? 365  PHE   A CE1 1 
ATOM   2680 C  CE2 . PHE   A 1  329 ? -23.978 0.295   -6.295  1    23.59   ? 365  PHE   A CE2 1 
ATOM   2681 C  CZ  . PHE   A 1  329 ? -23.017 -0.739  -6.427  1    24.184  ? 365  PHE   A CZ  1 
ATOM   2682 N  N   . ARG   A 1  330 ? -20.469 6.107   -7.809  1    20.399  ? 366  ARG   A N   1 
ATOM   2683 C  CA  . ARG   A 1  330 ? -20.539 7.535   -8.124  1    17.398  ? 366  ARG   A CA  1 
ATOM   2684 C  C   . ARG   A 1  330 ? -19.985 7.83    -9.525  1    18.412  ? 366  ARG   A C   1 
ATOM   2685 O  O   . ARG   A 1  330 ? -19.018 7.193   -10.003 1    18.97   ? 366  ARG   A O   1 
ATOM   2686 C  CB  . ARG   A 1  330 ? -19.606 8.253   -7.141  1    18.653  ? 366  ARG   A CB  1 
ATOM   2687 C  CG  . ARG   A 1  330 ? -20.01  8.114   -5.663  1    25.76   ? 366  ARG   A CG  1 
ATOM   2688 C  CD  . ARG   A 1  330 ? -19.128 8.991   -4.776  1    22.36   ? 366  ARG   A CD  1 
ATOM   2689 N  NE  . ARG   A 1  330 ? -19.176 8.268   -3.49   1    26.6    ? 366  ARG   A NE  1 
ATOM   2690 C  CZ  . ARG   A 1  330 ? -18.431 8.619   -2.449  1    29.529  ? 366  ARG   A CZ  1 
ATOM   2691 N  NH1 . ARG   A 1  330 ? -17.617 9.666   -2.551  1    26.689  ? 366  ARG   A NH1 1 
ATOM   2692 N  NH2 . ARG   A 1  330 ? -18.466 7.892   -1.33   1    27.814  ? 366  ARG   A NH2 1 
ATOM   2693 N  N   . ILE   A 1  331 ? -20.318 9.022   -10.011 1    20.952  ? 367  ILE   A N   1 
ATOM   2694 C  CA  . ILE   A 1  331 ? -19.63  9.597   -11.166 1    22.116  ? 367  ILE   A CA  1 
ATOM   2695 C  C   . ILE   A 1  331 ? -19.018 10.947  -10.798 1    22.772  ? 367  ILE   A C   1 
ATOM   2696 O  O   . ILE   A 1  331 ? -19.571 11.696  -9.976  1    21.802  ? 367  ILE   A O   1 
ATOM   2697 C  CB  . ILE   A 1  331 ? -20.606 9.652   -12.366 1    19.346  ? 367  ILE   A CB  1 
ATOM   2698 C  CG1 . ILE   A 1  331 ? -20.82  8.25    -12.971 1    18.573  ? 367  ILE   A CG1 1 
ATOM   2699 C  CG2 . ILE   A 1  331 ? -20.132 10.614  -13.455 1    18.764  ? 367  ILE   A CG2 1 
ATOM   2700 C  CD1 . ILE   A 1  331 ? -22.008 8.159   -13.959 1    20.171  ? 367  ILE   A CD1 1 
ATOM   2701 N  N   . LYS   A 1  332 ? -17.809 11.199  -11.319 1    20.9    ? 368  LYS   A N   1 
ATOM   2702 C  CA  . LYS   A 1  332 ? -17.158 12.487  -11.209 1    19.642  ? 368  LYS   A CA  1 
ATOM   2703 C  C   . LYS   A 1  332 ? -16.899 12.965  -12.645 1    23.274  ? 368  LYS   A C   1 
ATOM   2704 O  O   . LYS   A 1  332 ? -16.032 12.431  -13.408 1    22.78   ? 368  LYS   A O   1 
ATOM   2705 C  CB  . LYS   A 1  332 ? -15.854 12.246  -10.459 1    18.899  ? 368  LYS   A CB  1 
ATOM   2706 C  CG  . LYS   A 1  332 ? -14.907 13.481  -10.541 1    21.56   ? 368  LYS   A CG  1 
ATOM   2707 C  CD  . LYS   A 1  332 ? -13.457 13.225  -10.13  1    19.967  ? 368  LYS   A CD  1 
ATOM   2708 C  CE  . LYS   A 1  332 ? -12.748 12.45   -11.22  1    27.97   ? 368  LYS   A CE  1 
ATOM   2709 N  NZ  . LYS   A 1  332 ? -12.989 12.93   -12.591 1    21.899  ? 368  LYS   A NZ  1 
ATOM   2710 N  N   . GLN   A 1  333 ? -17.698 13.958  -13.037 1    22.805  ? 369  GLN   A N   1 
ATOM   2711 C  CA  . GLN   A 1  333 ? -17.553 14.496  -14.385 1    18.551  ? 369  GLN   A CA  1 
ATOM   2712 C  C   . GLN   A 1  333 ? -17.699 16.012  -14.318 1    21.089  ? 369  GLN   A C   1 
ATOM   2713 O  O   . GLN   A 1  333 ? -18.623 16.509  -13.697 1    22.745  ? 369  GLN   A O   1 
ATOM   2714 C  CB  . GLN   A 1  333 ? -18.644 13.899  -15.254 1    17.992  ? 369  GLN   A CB  1 
ATOM   2715 C  CG  . GLN   A 1  333 ? -18.485 14.327  -16.719 1    18.46   ? 369  GLN   A CG  1 
ATOM   2716 C  CD  . GLN   A 1  333 ? -19.424 13.565  -17.621 1    19.687  ? 369  GLN   A CD  1 
ATOM   2717 O  OE1 . GLN   A 1  333 ? -19.738 12.418  -17.332 1    22.087  ? 369  GLN   A OE1 1 
ATOM   2718 N  NE2 . GLN   A 1  333 ? -19.884 14.176  -18.704 1    20.484  ? 369  GLN   A NE2 1 
ATOM   2719 N  N   . CYS   A 1  334 ? -16.842 16.755  -14.982 1    22.524  ? 370  CYS   A N   1 
ATOM   2720 C  CA  . CYS   A 1  334 ? -17.084 18.181  -15.151 1    23.229  ? 370  CYS   A CA  1 
ATOM   2721 C  C   . CYS   A 1  334 ? -17.993 18.431  -16.354 1    20.103  ? 370  CYS   A C   1 
ATOM   2722 O  O   . CYS   A 1  334 ? -17.514 18.908  -17.367 1    20.376  ? 370  CYS   A O   1 
ATOM   2723 C  CB  . CYS   A 1  334 ? -15.768 18.93   -15.31  1    21.948  ? 370  CYS   A CB  1 
ATOM   2724 S  SG  . CYS   A 1  334 ? -14.72  18.803  -13.82  1    27.427  ? 370  CYS   A SG  1 
ATOM   2725 N  N   . THR   A 1  335 ? -19.3   18.166  -16.186 1    21.216  ? 371  THR   A N   1 
ATOM   2726 C  CA  . THR   A 1  335 ? -20.218 18.017  -17.288 1    20.229  ? 371  THR   A CA  1 
ATOM   2727 C  C   . THR   A 1  335 ? -20.417 19.367  -17.942 1    23.425  ? 371  THR   A C   1 
ATOM   2728 O  O   . THR   A 1  335 ? -20.704 20.32   -17.223 1    23.964  ? 371  THR   A O   1 
ATOM   2729 C  CB  . THR   A 1  335 ? -21.562 17.497  -16.76  1    21.015  ? 371  THR   A CB  1 
ATOM   2730 O  OG1 . THR   A 1  335 ? -21.208 16.293  -16.061 1    19.612  ? 371  THR   A OG1 1 
ATOM   2731 C  CG2 . THR   A 1  335 ? -22.388 16.966  -17.917 1    21.167  ? 371  THR   A CG2 1 
ATOM   2732 N  N   . THR   A 1  336 ? -20.308 19.41   -19.28  1    21.286  ? 372  THR   A N   1 
ATOM   2733 C  CA  . THR   A 1  336 ? -20.759 20.563  -20.052 1    20.85   ? 372  THR   A CA  1 
ATOM   2734 C  C   . THR   A 1  336 ? -22.122 20.237  -20.637 1    22.363  ? 372  THR   A C   1 
ATOM   2735 O  O   . THR   A 1  336 ? -22.359 19.089  -21.047 1    22.359  ? 372  THR   A O   1 
ATOM   2736 C  CB  . THR   A 1  336 ? -19.769 20.814  -21.185 1    27.393  ? 372  THR   A CB  1 
ATOM   2737 O  OG1 . THR   A 1  336 ? -18.689 21.298  -20.407 1    29.344  ? 372  THR   A OG1 1 
ATOM   2738 C  CG2 . THR   A 1  336 ? -20.172 22.026  -22.023 1    27.442  ? 372  THR   A CG2 1 
ATOM   2739 N  N   . VAL   A 1  337 ? -23.031 21.221  -20.766 1    24.743  ? 373  VAL   A N   1 
ATOM   2740 C  CA  . VAL   A 1  337 ? -24.343 20.917  -21.33  1    21.907  ? 373  VAL   A CA  1 
ATOM   2741 C  C   . VAL   A 1  337 ? -24.203 20.928  -22.869 1    25.529  ? 373  VAL   A C   1 
ATOM   2742 O  O   . VAL   A 1  337 ? -24.329 21.969  -23.479 1    27.428  ? 373  VAL   A O   1 
ATOM   2743 C  CB  . VAL   A 1  337 ? -25.364 21.954  -20.818 1    22.652  ? 373  VAL   A CB  1 
ATOM   2744 C  CG1 . VAL   A 1  337 ? -26.728 21.728  -21.481 1    20.74   ? 373  VAL   A CG1 1 
ATOM   2745 C  CG2 . VAL   A 1  337 ? -25.521 21.908  -19.3   1    21.99   ? 373  VAL   A CG2 1 
ATOM   2746 N  N   . ASN   A 1  338 ? -24.013 19.765  -23.519 1    23.73   ? 374  ASN   A N   1 
ATOM   2747 C  CA  . ASN   A 1  338 ? -23.968 19.593  -24.964 1    21.141  ? 374  ASN   A CA  1 
ATOM   2748 C  C   . ASN   A 1  338 ? -24.205 18.118  -25.246 1    21.654  ? 374  ASN   A C   1 
ATOM   2749 O  O   . ASN   A 1  338 ? -24.275 17.327  -24.286 1    24.111  ? 374  ASN   A O   1 
ATOM   2750 C  CB  . ASN   A 1  338 ? -22.702 20.045  -25.661 1    21.859  ? 374  ASN   A CB  1 
ATOM   2751 C  CG  . ASN   A 1  338 ? -21.446 19.436  -25.114 1    25.926  ? 374  ASN   A CG  1 
ATOM   2752 O  OD1 . ASN   A 1  338 ? -21.378 18.251  -24.782 1    26.823  ? 374  ASN   A OD1 1 
ATOM   2753 N  ND2 . ASN   A 1  338 ? -20.453 20.265  -24.931 1    27.132  ? 374  ASN   A ND2 1 
ATOM   2754 N  N   . LEU   A 1  339 ? -24.34  17.774  -26.534 1    20.391  ? 375  LEU   A N   1 
ATOM   2755 C  CA  . LEU   A 1  339 ? -24.738 16.411  -26.821 1    23.385  ? 375  LEU   A CA  1 
ATOM   2756 C  C   . LEU   A 1  339 ? -23.54  15.492  -26.616 1    25.33   ? 375  LEU   A C   1 
ATOM   2757 O  O   . LEU   A 1  339 ? -23.685 14.31   -26.233 1    24.061  ? 375  LEU   A O   1 
ATOM   2758 C  CB  . LEU   A 1  339 ? -25.249 16.41   -28.27  1    24.928  ? 375  LEU   A CB  1 
ATOM   2759 C  CG  . LEU   A 1  339 ? -25.621 15.047  -28.867 1    26.928  ? 375  LEU   A CG  1 
ATOM   2760 C  CD1 . LEU   A 1  339 ? -26.722 14.409  -28.021 1    30.16   ? 375  LEU   A CD1 1 
ATOM   2761 C  CD2 . LEU   A 1  339 ? -25.967 15.089  -30.379 1    28.439  ? 375  LEU   A CD2 1 
ATOM   2762 N  N   . GLU   A 1  340 ? -22.336 16.021  -26.945 1    25.868  ? 376  GLU   A N   1 
ATOM   2763 C  CA  . GLU   A 1  340 ? -21.102 15.279  -26.739 1    27.349  ? 376  GLU   A CA  1 
ATOM   2764 C  C   . GLU   A 1  340 ? -21.023 14.788  -25.296 1    21.743  ? 376  GLU   A C   1 
ATOM   2765 O  O   . GLU   A 1  340 ? -20.781 13.59   -25.043 1    22.053  ? 376  GLU   A O   1 
ATOM   2766 C  CB  . GLU   A 1  340 ? -19.87  16.169  -26.944 1    31.004  ? 376  GLU   A CB  1 
ATOM   2767 C  CG  . GLU   A 1  340 ? -18.548 15.426  -26.88  1    39.835  ? 376  GLU   A CG  1 
ATOM   2768 C  CD  . GLU   A 1  340 ? -17.617 16.209  -27.809 1    46.504  ? 376  GLU   A CD  1 
ATOM   2769 O  OE1 . GLU   A 1  340 ? -17.831 17.403  -28.037 1    43.207  ? 376  GLU   A OE1 1 
ATOM   2770 O  OE2 . GLU   A 1  340 ? -16.76  15.594  -28.423 1    49.486  ? 376  GLU   A OE2 1 
ATOM   2771 N  N   . ASP   A 1  341 ? -21.258 15.668  -24.335 1    17.692  ? 377  ASP   A N   1 
ATOM   2772 C  CA  . ASP   A 1  341 ? -21.174 15.175  -22.955 1    22.103  ? 377  ASP   A CA  1 
ATOM   2773 C  C   . ASP   A 1  341 ? -22.407 14.343  -22.545 1    22.762  ? 377  ASP   A C   1 
ATOM   2774 O  O   . ASP   A 1  341 ? -22.379 13.66   -21.522 1    21.471  ? 377  ASP   A O   1 
ATOM   2775 C  CB  . ASP   A 1  341 ? -21.101 16.292  -21.928 1    24.376  ? 377  ASP   A CB  1 
ATOM   2776 C  CG  . ASP   A 1  341 ? -19.655 16.621  -21.59  1    38.078  ? 377  ASP   A CG  1 
ATOM   2777 O  OD1 . ASP   A 1  341 ? -18.778 16.084  -22.298 1    39.695  ? 377  ASP   A OD1 1 
ATOM   2778 O  OD2 . ASP   A 1  341 ? -19.411 17.379  -20.64  1    35.445  ? 377  ASP   A OD2 1 
ATOM   2779 N  N   . LEU   A 1  342 ? -23.54  14.557  -23.221 1    22.327  ? 378  LEU   A N   1 
ATOM   2780 C  CA  . LEU   A 1  342 ? -24.685 13.696  -22.943 1    22.635  ? 378  LEU   A CA  1 
ATOM   2781 C  C   . LEU   A 1  342 ? -24.266 12.246  -23.202 1    18.494  ? 378  LEU   A C   1 
ATOM   2782 O  O   . LEU   A 1  342 ? -24.561 11.36   -22.415 1    19.287  ? 378  LEU   A O   1 
ATOM   2783 C  CB  . LEU   A 1  342 ? -25.897 14.054  -23.798 1    21.872  ? 378  LEU   A CB  1 
ATOM   2784 C  CG  . LEU   A 1  342 ? -27.184 13.252  -23.487 1    24.513  ? 378  LEU   A CG  1 
ATOM   2785 C  CD1 . LEU   A 1  342 ? -27.626 13.351  -22.027 1    22.87   ? 378  LEU   A CD1 1 
ATOM   2786 C  CD2 . LEU   A 1  342 ? -28.249 13.817  -24.408 1    26.708  ? 378  LEU   A CD2 1 
ATOM   2787 N  N   . VAL   A 1  343 ? -23.65  12.003  -24.354 1    17.498  ? 379  VAL   A N   1 
ATOM   2788 C  CA  . VAL   A 1  343 ? -23.103 10.69   -24.719 1    18.35   ? 379  VAL   A CA  1 
ATOM   2789 C  C   . VAL   A 1  343 ? -22.083 10.231  -23.658 1    18.759  ? 379  VAL   A C   1 
ATOM   2790 O  O   . VAL   A 1  343 ? -22.092 9.065   -23.211 1    20.403  ? 379  VAL   A O   1 
ATOM   2791 C  CB  . VAL   A 1  343 ? -22.539 10.74   -26.156 1    19.791  ? 379  VAL   A CB  1 
ATOM   2792 C  CG1 . VAL   A 1  343 ? -21.84  9.415   -26.518 1    19.275  ? 379  VAL   A CG1 1 
ATOM   2793 C  CG2 . VAL   A 1  343 ? -23.683 10.965  -27.18  1    21.647  ? 379  VAL   A CG2 1 
ATOM   2794 N  N   . VAL   A 1  344 ? -21.157 11.112  -23.232 1    19.2    ? 380  VAL   A N   1 
ATOM   2795 C  CA  . VAL   A 1  344 ? -20.227 10.711  -22.157 1    19.929  ? 380  VAL   A CA  1 
ATOM   2796 C  C   . VAL   A 1  344 ? -20.997 10.334  -20.881 1    21.681  ? 380  VAL   A C   1 
ATOM   2797 O  O   . VAL   A 1  344 ? -20.667 9.317   -20.219 1    20.844  ? 380  VAL   A O   1 
ATOM   2798 C  CB  . VAL   A 1  344 ? -19.144 11.793  -21.868 1    16.286  ? 380  VAL   A CB  1 
ATOM   2799 C  CG1 . VAL   A 1  344 ? -18.315 11.554  -20.597 1    16.626  ? 380  VAL   A CG1 1 
ATOM   2800 C  CG2 . VAL   A 1  344 ? -18.295 12.063  -23.112 1    17.565  ? 380  VAL   A CG2 1 
ATOM   2801 N  N   . ALA   A 1  345 ? -22.04  11.133  -20.521 1    18.562  ? 381  ALA   A N   1 
ATOM   2802 C  CA  . ALA   A 1  345 ? -22.812 10.752  -19.322 1    15.973  ? 381  ALA   A CA  1 
ATOM   2803 C  C   . ALA   A 1  345 ? -23.33  9.313   -19.455 1    18.457  ? 381  ALA   A C   1 
ATOM   2804 O  O   . ALA   A 1  345 ? -23.286 8.602   -18.462 1    19.023  ? 381  ALA   A O   1 
ATOM   2805 C  CB  . ALA   A 1  345 ? -23.983 11.698  -19.083 1    15.41   ? 381  ALA   A CB  1 
ATOM   2806 N  N   . HIS   A 1  346 ? -23.886 8.921   -20.634 1    18.922  ? 382  HIS   A N   1 
ATOM   2807 C  CA  . HIS   A 1  346 ? -24.384 7.557   -20.841 1    18.412  ? 382  HIS   A CA  1 
ATOM   2808 C  C   . HIS   A 1  346 ? -23.237 6.554   -20.646 1    17.078  ? 382  HIS   A C   1 
ATOM   2809 O  O   . HIS   A 1  346 ? -23.465 5.477   -20.09  1    17.582  ? 382  HIS   A O   1 
ATOM   2810 C  CB  . HIS   A 1  346 ? -25.073 7.407   -22.225 1    18.286  ? 382  HIS   A CB  1 
ATOM   2811 C  CG  . HIS   A 1  346 ? -26.459 7.981   -22.202 1    20.244  ? 382  HIS   A CG  1 
ATOM   2812 N  ND1 . HIS   A 1  346 ? -26.709 9.338   -22.254 1    20.366  ? 382  HIS   A ND1 1 
ATOM   2813 C  CD2 . HIS   A 1  346 ? -27.665 7.406   -22.036 1    23.53   ? 382  HIS   A CD2 1 
ATOM   2814 C  CE1 . HIS   A 1  346 ? -28.023 9.566   -22.212 1    21.766  ? 382  HIS   A CE1 1 
ATOM   2815 N  NE2 . HIS   A 1  346 ? -28.619 8.424   -22.029 1    22.724  ? 382  HIS   A NE2 1 
ATOM   2816 N  N   . HIS   A 1  347 ? -22.075 6.872   -21.256 1    19.504  ? 383  HIS   A N   1 
ATOM   2817 C  CA  . HIS   A 1  347 ? -20.866 6.057   -21.211 1    17.564  ? 383  HIS   A CA  1 
ATOM   2818 C  C   . HIS   A 1  347 ? -20.579 5.679   -19.761 1    17.285  ? 383  HIS   A C   1 
ATOM   2819 O  O   . HIS   A 1  347 ? -20.398 4.493   -19.391 1    16.894  ? 383  HIS   A O   1 
ATOM   2820 C  CB  . HIS   A 1  347 ? -19.73  6.702   -22.029 1    19.039  ? 383  HIS   A CB  1 
ATOM   2821 C  CG  . HIS   A 1  347 ? -18.455 5.898   -21.894 1    18.962  ? 383  HIS   A CG  1 
ATOM   2822 N  ND1 . HIS   A 1  347 ? -18.094 4.953   -22.824 1    20.876  ? 383  HIS   A ND1 1 
ATOM   2823 C  CD2 . HIS   A 1  347 ? -17.512 5.829   -20.85  1    17.502  ? 383  HIS   A CD2 1 
ATOM   2824 C  CE1 . HIS   A 1  347 ? -16.949 4.349   -22.419 1    21.717  ? 383  HIS   A CE1 1 
ATOM   2825 N  NE2 . HIS   A 1  347 ? -16.582 4.876   -21.187 1    19.76   ? 383  HIS   A NE2 1 
ATOM   2826 N  N   . GLU   A 1  348 ? -20.492 6.732   -18.944 1    15.986  ? 384  GLU   A N   1 
ATOM   2827 C  CA  . GLU   A 1  348 ? -20.127 6.583   -17.539 1    17.916  ? 384  GLU   A CA  1 
ATOM   2828 C  C   . GLU   A 1  348 ? -21.218 5.806   -16.795 1    19.141  ? 384  GLU   A C   1 
ATOM   2829 O  O   . GLU   A 1  348 ? -20.93  4.96    -15.942 1    19.539  ? 384  GLU   A O   1 
ATOM   2830 C  CB  . GLU   A 1  348 ? -19.919 7.99    -16.949 1    16.279  ? 384  GLU   A CB  1 
ATOM   2831 C  CG  . GLU   A 1  348 ? -18.757 8.745   -17.613 1    20.062  ? 384  GLU   A CG  1 
ATOM   2832 C  CD  . GLU   A 1  348 ? -17.411 7.991   -17.469 1    22.661  ? 384  GLU   A CD  1 
ATOM   2833 O  OE1 . GLU   A 1  348 ? -17.274 7.143   -16.557 1    22.238  ? 384  GLU   A OE1 1 
ATOM   2834 O  OE2 . GLU   A 1  348 ? -16.516 8.188   -18.353 1    22.314  ? 384  GLU   A OE2 1 
ATOM   2835 N  N   . MET   A 1  349 ? -22.495 6.113   -17.076 1    16.993  ? 385  MET   A N   1 
ATOM   2836 C  CA  . MET   A 1  349 ? -23.629 5.375   -16.505 1    19.383  ? 385  MET   A CA  1 
ATOM   2837 C  C   . MET   A 1  349 ? -23.572 3.882   -16.826 1    17.731  ? 385  MET   A C   1 
ATOM   2838 O  O   . MET   A 1  349 ? -24.06  3.079   -16.031 1    20.275  ? 385  MET   A O   1 
ATOM   2839 C  CB  . MET   A 1  349 ? -24.979 6.051   -16.867 1    17.233  ? 385  MET   A CB  1 
ATOM   2840 C  CG  . MET   A 1  349 ? -25.077 7.426   -16.159 1    17.676  ? 385  MET   A CG  1 
ATOM   2841 S  SD  . MET   A 1  349 ? -25.445 7.235   -14.372 1    22.045  ? 385  MET   A SD  1 
ATOM   2842 C  CE  . MET   A 1  349 ? -27.231 7.115   -14.606 1    21.106  ? 385  MET   A CE  1 
ATOM   2843 N  N   . GLY   A 1  350 ? -23.028 3.502   -17.995 1    17.279  ? 386  GLY   A N   1 
ATOM   2844 C  CA  . GLY   A 1  350 ? -22.858 2.091   -18.319 1    18.249  ? 386  GLY   A CA  1 
ATOM   2845 C  C   . GLY   A 1  350 ? -21.88  1.411   -17.36  1    18.76   ? 386  GLY   A C   1 
ATOM   2846 O  O   . GLY   A 1  350 ? -22.062 0.244   -16.988 1    19.397  ? 386  GLY   A O   1 
ATOM   2847 N  N   . HIS   A 1  351 ? -20.839 2.162   -16.957 1    19.575  ? 387  HIS   A N   1 
ATOM   2848 C  CA  . HIS   A 1  351 ? -19.856 1.611   -16.024 1    18.547  ? 387  HIS   A CA  1 
ATOM   2849 C  C   . HIS   A 1  351 ? -20.525 1.512   -14.664 1    18.587  ? 387  HIS   A C   1 
ATOM   2850 O  O   . HIS   A 1  351 ? -20.421 0.433   -14.057 1    17.88   ? 387  HIS   A O   1 
ATOM   2851 C  CB  . HIS   A 1  351 ? -18.659 2.547   -15.853 1    18.864  ? 387  HIS   A CB  1 
ATOM   2852 C  CG  . HIS   A 1  351 ? -17.708 2.519   -16.971 1    18.509  ? 387  HIS   A CG  1 
ATOM   2853 N  ND1 . HIS   A 1  351 ? -17.195 1.357   -17.563 1    16.554  ? 387  HIS   A ND1 1 
ATOM   2854 C  CD2 . HIS   A 1  351 ? -17.191 3.597   -17.563 1    15.818  ? 387  HIS   A CD2 1 
ATOM   2855 C  CE1 . HIS   A 1  351 ? -16.326 1.768   -18.516 1    16.72   ? 387  HIS   A CE1 1 
ATOM   2856 N  NE2 . HIS   A 1  351 ? -16.311 3.111   -18.507 1    18.639  ? 387  HIS   A NE2 1 
ATOM   2857 N  N   . ILE   A 1  352 ? -21.348 2.508   -14.291 1    17.336  ? 388  ILE   A N   1 
ATOM   2858 C  CA  . ILE   A 1  352 ? -22.129 2.318   -13.034 1    18.885  ? 388  ILE   A CA  1 
ATOM   2859 C  C   . ILE   A 1  352 ? -23.047 1.08    -13.113 1    20.613  ? 388  ILE   A C   1 
ATOM   2860 O  O   . ILE   A 1  352 ? -23.187 0.317   -12.172 1    18.738  ? 388  ILE   A O   1 
ATOM   2861 C  CB  . ILE   A 1  352 ? -22.892 3.592   -12.688 1    19.379  ? 388  ILE   A CB  1 
ATOM   2862 C  CG1 . ILE   A 1  352 ? -21.841 4.786   -12.541 1    18.945  ? 388  ILE   A CG1 1 
ATOM   2863 C  CG2 . ILE   A 1  352 ? -23.842 3.405   -11.496 1    16.604  ? 388  ILE   A CG2 1 
ATOM   2864 C  CD1 . ILE   A 1  352 ? -20.978 4.757   -11.302 1    17.964  ? 388  ILE   A CD1 1 
ATOM   2865 N  N   . GLN   A 1  353 ? -23.709 0.869   -14.246 1    18.638  ? 389  GLN   A N   1 
ATOM   2866 C  CA  . GLN   A 1  353 ? -24.654 -0.225  -14.326 1    19.599  ? 389  GLN   A CA  1 
ATOM   2867 C  C   . GLN   A 1  353 ? -23.919 -1.569  -14.223 1    18.511  ? 389  GLN   A C   1 
ATOM   2868 O  O   . GLN   A 1  353 ? -24.438 -2.468  -13.512 1    23.192  ? 389  GLN   A O   1 
ATOM   2869 C  CB  . GLN   A 1  353 ? -25.377 -0.187  -15.674 1    20.257  ? 389  GLN   A CB  1 
ATOM   2870 C  CG  . GLN   A 1  353 ? -26.401 -1.33   -15.832 1    17.416  ? 389  GLN   A CG  1 
ATOM   2871 C  CD  . GLN   A 1  353 ? -27.644 -1.187  -14.966 1    21.965  ? 389  GLN   A CD  1 
ATOM   2872 O  OE1 . GLN   A 1  353 ? -28.318 -2.205  -14.646 1    20.102  ? 389  GLN   A OE1 1 
ATOM   2873 N  NE2 . GLN   A 1  353 ? -28.014 0.055   -14.639 1    20.317  ? 389  GLN   A NE2 1 
ATOM   2874 N  N   . TYR   A 1  354 ? -22.708 -1.672  -14.818 1    15.534  ? 390  TYR   A N   1 
ATOM   2875 C  CA  . TYR   A 1  354 ? -21.919 -2.903  -14.697 1    16.913  ? 390  TYR   A CA  1 
ATOM   2876 C  C   . TYR   A 1  354 ? -21.551 -3.094  -13.208 1    18.348  ? 390  TYR   A C   1 
ATOM   2877 O  O   . TYR   A 1  354 ? -21.718 -4.177  -12.629 1    17.896  ? 390  TYR   A O   1 
ATOM   2878 C  CB  . TYR   A 1  354 ? -20.696 -2.767  -15.616 1    15.036  ? 390  TYR   A CB  1 
ATOM   2879 C  CG  . TYR   A 1  354 ? -20.361 -4.008  -16.421 1    15.667  ? 390  TYR   A CG  1 
ATOM   2880 C  CD1 . TYR   A 1  354 ? -20.443 -5.286  -15.856 1    16.239  ? 390  TYR   A CD1 1 
ATOM   2881 C  CD2 . TYR   A 1  354 ? -20.056 -3.885  -17.768 1    15.451  ? 390  TYR   A CD2 1 
ATOM   2882 C  CE1 . TYR   A 1  354 ? -20.136 -6.418  -16.592 1    15.216  ? 390  TYR   A CE1 1 
ATOM   2883 C  CE2 . TYR   A 1  354 ? -19.782 -5.008  -18.52  1    16.044  ? 390  TYR   A CE2 1 
ATOM   2884 C  CZ  . TYR   A 1  354 ? -19.819 -6.261  -17.927 1    18.482  ? 390  TYR   A CZ  1 
ATOM   2885 O  OH  . TYR   A 1  354 ? -19.474 -7.334  -18.678 1    18.055  ? 390  TYR   A OH  1 
ATOM   2886 N  N   . PHE   A 1  355 ? -21.097 -2.044  -12.524 1    19.462  ? 391  PHE   A N   1 
ATOM   2887 C  CA  . PHE   A 1  355 ? -20.769 -2.223  -11.093 1    21.074  ? 391  PHE   A CA  1 
ATOM   2888 C  C   . PHE   A 1  355 ? -21.966 -2.757  -10.298 1    21.137  ? 391  PHE   A C   1 
ATOM   2889 O  O   . PHE   A 1  355 ? -21.8   -3.635  -9.422  1    26.56   ? 391  PHE   A O   1 
ATOM   2890 C  CB  . PHE   A 1  355 ? -20.413 -0.929  -10.365 1    16.137  ? 391  PHE   A CB  1 
ATOM   2891 C  CG  . PHE   A 1  355 ? -19.31  -0.081  -10.991 1    16.68   ? 391  PHE   A CG  1 
ATOM   2892 C  CD1 . PHE   A 1  355 ? -18.242 -0.679  -11.672 1    15.908  ? 391  PHE   A CD1 1 
ATOM   2893 C  CD2 . PHE   A 1  355 ? -19.325 1.304   -10.879 1    18.367  ? 391  PHE   A CD2 1 
ATOM   2894 C  CE1 . PHE   A 1  355 ? -17.165 0.078   -12.161 1    19.54   ? 391  PHE   A CE1 1 
ATOM   2895 C  CE2 . PHE   A 1  355 ? -18.237 2.052   -11.357 1    16.35   ? 391  PHE   A CE2 1 
ATOM   2896 C  CZ  . PHE   A 1  355 ? -17.199 1.464   -12.027 1    18.924  ? 391  PHE   A CZ  1 
ATOM   2897 N  N   . MET   A 1  356 ? -23.173 -2.257  -10.634 1    21.921  ? 392  MET   A N   1 
ATOM   2898 C  CA  . MET   A 1  356 ? -24.35  -2.646  -9.871  1    22.406  ? 392  MET   A CA  1 
ATOM   2899 C  C   . MET   A 1  356 ? -24.769 -4.069  -10.224 1    26.158  ? 392  MET   A C   1 
ATOM   2900 O  O   . MET   A 1  356 ? -25.229 -4.81   -9.339  1    28.05   ? 392  MET   A O   1 
ATOM   2901 C  CB  . MET   A 1  356 ? -25.53  -1.707  -10.11  1    23.787  ? 392  MET   A CB  1 
ATOM   2902 C  CG  . MET   A 1  356 ? -25.24  -0.333  -9.614  1    27.987  ? 392  MET   A CG  1 
ATOM   2903 S  SD  . MET   A 1  356 ? -26.734 0.679   -9.545  1    26.828  ? 392  MET   A SD  1 
ATOM   2904 C  CE  . MET   A 1  356 ? -27.091 0.662   -11.326 1    20.738  ? 392  MET   A CE  1 
ATOM   2905 N  N   . GLN   A 1  357 ? -24.51  -4.468  -11.476 1    20.383  ? 393  GLN   A N   1 
ATOM   2906 C  CA  . GLN   A 1  357 ? -24.932 -5.769  -11.965 1    18.76   ? 393  GLN   A CA  1 
ATOM   2907 C  C   . GLN   A 1  357 ? -24.048 -6.865  -11.369 1    24.833  ? 393  GLN   A C   1 
ATOM   2908 O  O   . GLN   A 1  357 ? -24.497 -8.005  -11.243 1    25.017  ? 393  GLN   A O   1 
ATOM   2909 C  CB  . GLN   A 1  357 ? -24.91  -5.73   -13.487 1    21.486  ? 393  GLN   A CB  1 
ATOM   2910 C  CG  . GLN   A 1  357 ? -26.08  -4.989  -14.125 1    20.856  ? 393  GLN   A CG  1 
ATOM   2911 C  CD  . GLN   A 1  357 ? -27.4   -5.718  -13.981 1    23.297  ? 393  GLN   A CD  1 
ATOM   2912 O  OE1 . GLN   A 1  357 ? -27.457 -6.918  -13.64  1    23.165  ? 393  GLN   A OE1 1 
ATOM   2913 N  NE2 . GLN   A 1  357 ? -28.474 -4.979  -14.261 1    22.457  ? 393  GLN   A NE2 1 
ATOM   2914 N  N   . TYR   A 1  358 ? -22.761 -6.571  -11.096 1    20.159  ? 394  TYR   A N   1 
ATOM   2915 C  CA  . TYR   A 1  358 ? -21.915 -7.681  -10.669 1    21.39   ? 394  TYR   A CA  1 
ATOM   2916 C  C   . TYR   A 1  358 ? -21.599 -7.529  -9.181  1    21.9    ? 394  TYR   A C   1 
ATOM   2917 O  O   . TYR   A 1  358 ? -20.748 -8.244  -8.669  1    27.217  ? 394  TYR   A O   1 
ATOM   2918 C  CB  . TYR   A 1  358 ? -20.682 -7.906  -11.555 1    17.668  ? 394  TYR   A CB  1 
ATOM   2919 C  CG  . TYR   A 1  358 ? -19.705 -6.742  -11.708 1    22.76   ? 394  TYR   A CG  1 
ATOM   2920 C  CD1 . TYR   A 1  358 ? -19.356 -5.899  -10.63  1    17.167  ? 394  TYR   A CD1 1 
ATOM   2921 C  CD2 . TYR   A 1  358 ? -19.114 -6.483  -12.949 1    21.053  ? 394  TYR   A CD2 1 
ATOM   2922 C  CE1 . TYR   A 1  358 ? -18.437 -4.87   -10.81  1    16.746  ? 394  TYR   A CE1 1 
ATOM   2923 C  CE2 . TYR   A 1  358 ? -18.173 -5.472  -13.109 1    21.052  ? 394  TYR   A CE2 1 
ATOM   2924 C  CZ  . TYR   A 1  358 ? -17.862 -4.622  -12.056 1    21.95   ? 394  TYR   A CZ  1 
ATOM   2925 O  OH  . TYR   A 1  358 ? -16.867 -3.659  -12.277 1    21.981  ? 394  TYR   A OH  1 
ATOM   2926 N  N   . LYS   A 1  359 ? -22.315 -6.652  -8.485  1    23.214  ? 395  LYS   A N   1 
ATOM   2927 C  CA  . LYS   A 1  359 ? -22     -6.317  -7.094  1    24.145  ? 395  LYS   A CA  1 
ATOM   2928 C  C   . LYS   A 1  359 ? -22.03  -7.547  -6.177  1    29.973  ? 395  LYS   A C   1 
ATOM   2929 O  O   . LYS   A 1  359 ? -21.35  -7.511  -5.185  1    27.715  ? 395  LYS   A O   1 
ATOM   2930 C  CB  . LYS   A 1  359 ? -22.878 -5.158  -6.602  1    23.74   ? 395  LYS   A CB  1 
ATOM   2931 C  CG  . LYS   A 1  359 ? -24.32  -5.589  -6.349  1    31.601  ? 395  LYS   A CG  1 
ATOM   2932 C  CD  . LYS   A 1  359 ? -25.105 -4.417  -5.74   1    34.035  ? 395  LYS   A CD  1 
ATOM   2933 C  CE  . LYS   A 1  359 ? -26.555 -4.729  -5.587  1    40.873  ? 395  LYS   A CE  1 
ATOM   2934 N  NZ  . LYS   A 1  359 ? -26.66  -5.902  -4.722  1    44.035  ? 395  LYS   A NZ  1 
ATOM   2935 N  N   . ASP   A 1  360 ? -22.665 -8.678  -6.55   1    30.181  ? 396  ASP   A N   1 
ATOM   2936 C  CA  . ASP   A 1  360 ? -22.709 -9.837  -5.654  1    30.633  ? 396  ASP   A CA  1 
ATOM   2937 C  C   . ASP   A 1  360 ? -21.629 -10.876 -5.965  1    34.561  ? 396  ASP   A C   1 
ATOM   2938 O  O   . ASP   A 1  360 ? -21.499 -11.91  -5.282  1    33.918  ? 396  ASP   A O   1 
ATOM   2939 C  CB  . ASP   A 1  360 ? -24.122 -10.39  -5.522  1    25.762  ? 396  ASP   A CB  1 
ATOM   2940 C  CG  . ASP   A 1  360 ? -25.01  -9.37   -4.818  1    38.293  ? 396  ASP   A CG  1 
ATOM   2941 O  OD1 . ASP   A 1  360 ? -24.499 -8.764  -3.833  1    40.548  ? 396  ASP   A OD1 1 
ATOM   2942 O  OD2 . ASP   A 1  360 ? -26.159 -9.16   -5.277  1    41.425  ? 396  ASP   A OD2 1 
ATOM   2943 N  N   . LEU   A 1  361 ? -20.785 -10.596 -6.95   1    24.511  ? 397  LEU   A N   1 
ATOM   2944 C  CA  . LEU   A 1  361 ? -19.706 -11.532 -7.183  1    25.401  ? 397  LEU   A CA  1 
ATOM   2945 C  C   . LEU   A 1  361 ? -18.61  -11.236 -6.165  1    28.686  ? 397  LEU   A C   1 
ATOM   2946 O  O   . LEU   A 1  361 ? -18.459 -10.067 -5.717  1    28.607  ? 397  LEU   A O   1 
ATOM   2947 C  CB  . LEU   A 1  361 ? -19.237 -11.366 -8.637  1    25.123  ? 397  LEU   A CB  1 
ATOM   2948 C  CG  . LEU   A 1  361 ? -20.191 -11.877 -9.728  1    29.198  ? 397  LEU   A CG  1 
ATOM   2949 C  CD1 . LEU   A 1  361 ? -19.582 -11.542 -11.125 1    27.708  ? 397  LEU   A CD1 1 
ATOM   2950 C  CD2 . LEU   A 1  361 ? -20.259 -13.406 -9.569  1    30.973  ? 397  LEU   A CD2 1 
ATOM   2951 N  N   . PRO   A 1  362 ? -17.762 -12.254 -5.872  1    30.364  ? 398  PRO   A N   1 
ATOM   2952 C  CA  . PRO   A 1  362 ? -16.491 -11.991 -5.196  1    29.28   ? 398  PRO   A CA  1 
ATOM   2953 C  C   . PRO   A 1  362 ? -15.797 -10.833 -5.944  1    31.903  ? 398  PRO   A C   1 
ATOM   2954 O  O   . PRO   A 1  362 ? -15.702 -10.894 -7.187  1    26.767  ? 398  PRO   A O   1 
ATOM   2955 C  CB  . PRO   A 1  362 ? -15.676 -13.279 -5.363  1    29.042  ? 398  PRO   A CB  1 
ATOM   2956 C  CG  . PRO   A 1  362 ? -16.63  -14.321 -5.916  1    27.397  ? 398  PRO   A CG  1 
ATOM   2957 C  CD  . PRO   A 1  362 ? -17.938 -13.66  -6.318  1    27.724  ? 398  PRO   A CD  1 
ATOM   2958 N  N   . VAL   A 1  363 ? -15.189 -9.881  -5.188  1    28.252  ? 399  VAL   A N   1 
ATOM   2959 C  CA  . VAL   A 1  363 ? -14.518 -8.691  -5.737  1    27.241  ? 399  VAL   A CA  1 
ATOM   2960 C  C   . VAL   A 1  363 ? -13.47  -9.042  -6.787  1    23.224  ? 399  VAL   A C   1 
ATOM   2961 O  O   . VAL   A 1  363 ? -13.333 -8.31   -7.771  1    23.809  ? 399  VAL   A O   1 
ATOM   2962 C  CB  . VAL   A 1  363 ? -13.978 -7.667  -4.731  1    33.835  ? 399  VAL   A CB  1 
ATOM   2963 C  CG1 . VAL   A 1  363 ? -15.055 -7.228  -3.779  1    35.128  ? 399  VAL   A CG1 1 
ATOM   2964 C  CG2 . VAL   A 1  363 ? -12.843 -8.292  -3.972  1    34.687  ? 399  VAL   A CG2 1 
ATOM   2965 N  N   . ALA   A 1  364 ? -12.813 -10.225 -6.695  1    22.562  ? 400  ALA   A N   1 
ATOM   2966 C  CA  . ALA   A 1  364 ? -11.849 -10.589 -7.737  1    22.102  ? 400  ALA   A CA  1 
ATOM   2967 C  C   . ALA   A 1  364 ? -12.492 -10.729 -9.112  1    23.463  ? 400  ALA   A C   1 
ATOM   2968 O  O   . ALA   A 1  364 ? -11.773 -10.727 -10.11  1    24.279  ? 400  ALA   A O   1 
ATOM   2969 C  CB  . ALA   A 1  364 ? -11.083 -11.915 -7.442  1    25.328  ? 400  ALA   A CB  1 
ATOM   2970 N  N   . LEU   A 1  365 ? -13.799 -11.004 -9.162  1    21.683  ? 401  LEU   A N   1 
ATOM   2971 C  CA  . LEU   A 1  365 ? -14.494 -11.255 -10.44  1    23.018  ? 401  LEU   A CA  1 
ATOM   2972 C  C   . LEU   A 1  365 ? -15.411 -10.092 -10.79  1    22.269  ? 401  LEU   A C   1 
ATOM   2973 O  O   . LEU   A 1  365 ? -16.301 -10.224 -11.688 1    23.299  ? 401  LEU   A O   1 
ATOM   2974 C  CB  . LEU   A 1  365 ? -15.301 -12.565 -10.429 1    23.633  ? 401  LEU   A CB  1 
ATOM   2975 C  CG  . LEU   A 1  365 ? -14.557 -13.835 -9.996  1    24.895  ? 401  LEU   A CG  1 
ATOM   2976 C  CD1 . LEU   A 1  365 ? -15.526 -15.067 -9.82   1    22.508  ? 401  LEU   A CD1 1 
ATOM   2977 C  CD2 . LEU   A 1  365 ? -13.358 -14.119 -10.92  1    20.581  ? 401  LEU   A CD2 1 
ATOM   2978 N  N   . ARG   A 1  366 ? -15.21  -8.982  -10.072 1    21.366  ? 402  ARG   A N   1 
ATOM   2979 C  CA  . ARG   A 1  366 ? -15.977 -7.748  -10.299 1    24.278  ? 402  ARG   A CA  1 
ATOM   2980 C  C   . ARG   A 1  366 ? -15.319 -6.894  -11.393 1    23.23   ? 402  ARG   A C   1 
ATOM   2981 O  O   . ARG   A 1  366 ? -14.811 -5.819  -11.129 1    23.379  ? 402  ARG   A O   1 
ATOM   2982 C  CB  . ARG   A 1  366 ? -16.124 -6.887  -9.04   1    24.427  ? 402  ARG   A CB  1 
ATOM   2983 C  CG  . ARG   A 1  366 ? -17.08  -7.554  -8.051  1    33.197  ? 402  ARG   A CG  1 
ATOM   2984 C  CD  . ARG   A 1  366 ? -17.49  -6.548  -6.998  1    30.323  ? 402  ARG   A CD  1 
ATOM   2985 N  NE  . ARG   A 1  366 ? -18.053 -7.301  -5.884  1    36.776  ? 402  ARG   A NE  1 
ATOM   2986 C  CZ  . ARG   A 1  366 ? -18.286 -6.736  -4.72   1    38.133  ? 402  ARG   A CZ  1 
ATOM   2987 N  NH1 . ARG   A 1  366 ? -18.245 -5.438  -4.573  1    38.205  ? 402  ARG   A NH1 1 
ATOM   2988 N  NH2 . ARG   A 1  366 ? -18.575 -7.476  -3.678  1    40.712  ? 402  ARG   A NH2 1 
ATOM   2989 N  N   . GLU   A 1  367 ? -15.28  -7.389  -12.63  1    23.669  ? 403  GLU   A N   1 
ATOM   2990 C  CA  . GLU   A 1  367 ? -14.795 -6.598  -13.763 1    21.535  ? 403  GLU   A CA  1 
ATOM   2991 C  C   . GLU   A 1  367 ? -15.682 -6.966  -14.934 1    19.79   ? 403  GLU   A C   1 
ATOM   2992 O  O   . GLU   A 1  367 ? -16.496 -7.915  -14.829 1    22.567  ? 403  GLU   A O   1 
ATOM   2993 C  CB  . GLU   A 1  367 ? -13.341 -7.031  -14.023 1    26.551  ? 403  GLU   A CB  1 
ATOM   2994 C  CG  . GLU   A 1  367 ? -12.396 -6.255  -13.099 1    38.397  ? 403  GLU   A CG  1 
ATOM   2995 C  CD  . GLU   A 1  367 ? -11.097 -6.978  -12.81  1    59.925  ? 403  GLU   A CD  1 
ATOM   2996 O  OE1 . GLU   A 1  367 ? -10.554 -7.753  -13.663 1    54.245  ? 403  GLU   A OE1 1 
ATOM   2997 O  OE2 . GLU   A 1  367 ? -10.615 -6.707  -11.684 1    70.365  ? 403  GLU   A OE2 1 
ATOM   2998 N  N   . GLY   A 1  368 ? -15.464 -6.332  -16.085 1    19.551  ? 404  GLY   A N   1 
ATOM   2999 C  CA  . GLY   A 1  368 ? -16.297 -6.743  -17.214 1    16.753  ? 404  GLY   A CA  1 
ATOM   3000 C  C   . GLY   A 1  368 ? -15.804 -8.067  -17.786 1    18.541  ? 404  GLY   A C   1 
ATOM   3001 O  O   . GLY   A 1  368 ? -14.692 -8.506  -17.423 1    16.373  ? 404  GLY   A O   1 
ATOM   3002 N  N   . ALA   A 1  369 ? -16.601 -8.704  -18.664 1    18.719  ? 405  ALA   A N   1 
ATOM   3003 C  CA  . ALA   A 1  369 ? -16.142 -9.978  -19.233 1    21.749  ? 405  ALA   A CA  1 
ATOM   3004 C  C   . ALA   A 1  369 ? -14.728 -9.811  -19.797 1    21.737  ? 405  ALA   A C   1 
ATOM   3005 O  O   . ALA   A 1  369 ? -13.872 -10.7   -19.716 1    19.384  ? 405  ALA   A O   1 
ATOM   3006 C  CB  . ALA   A 1  369 ? -17.128 -10.369 -20.31  1    17.796  ? 405  ALA   A CB  1 
ATOM   3007 N  N   . ASN   A 1  370 ? -14.473 -8.672  -20.468 1    18.118  ? 406  ASN   A N   1 
ATOM   3008 C  CA  . ASN   A 1  370 ? -13.11  -8.179  -20.719 1    16.461  ? 406  ASN   A CA  1 
ATOM   3009 C  C   . ASN   A 1  370 ? -13.272 -6.648  -20.629 1    17.349  ? 406  ASN   A C   1 
ATOM   3010 O  O   . ASN   A 1  370 ? -14.399 -6.229  -20.435 1    18.709  ? 406  ASN   A O   1 
ATOM   3011 C  CB  . ASN   A 1  370 ? -12.504 -8.682  -22.047 1    16.532  ? 406  ASN   A CB  1 
ATOM   3012 C  CG  . ASN   A 1  370 ? -13.198 -8.143  -23.278 1    18.524  ? 406  ASN   A CG  1 
ATOM   3013 O  OD1 . ASN   A 1  370 ? -13.391 -6.915  -23.406 1    19.798  ? 406  ASN   A OD1 1 
ATOM   3014 N  ND2 . ASN   A 1  370 ? -13.401 -9.008  -24.273 1    20.097  ? 406  ASN   A ND2 1 
ATOM   3015 N  N   . PRO   A 1  371 ? -12.195 -5.811  -20.612 1    15.806  ? 407  PRO   A N   1 
ATOM   3016 C  CA  . PRO   A 1  371 ? -12.357 -4.378  -20.365 1    15.879  ? 407  PRO   A CA  1 
ATOM   3017 C  C   . PRO   A 1  371 ? -13.198 -3.684  -21.409 1    15.843  ? 407  PRO   A C   1 
ATOM   3018 O  O   . PRO   A 1  371 ? -13.784 -2.619  -21.15  1    19.201  ? 407  PRO   A O   1 
ATOM   3019 C  CB  . PRO   A 1  371 ? -10.88  -3.865  -20.34  1    16.588  ? 407  PRO   A CB  1 
ATOM   3020 C  CG  . PRO   A 1  371 ? -10.099 -5.048  -19.766 1    18.884  ? 407  PRO   A CG  1 
ATOM   3021 C  CD  . PRO   A 1  371 ? -10.763 -6.256  -20.469 1    16.448  ? 407  PRO   A CD  1 
ATOM   3022 N  N   . GLY   A 1  372 ? -13.137 -4.237  -22.626 1    19.193  ? 408  GLY   A N   1 
ATOM   3023 C  CA  . GLY   A 1  372 ? -13.946 -3.781  -23.757 1    17.532  ? 408  GLY   A CA  1 
ATOM   3024 C  C   . GLY   A 1  372 ? -15.442 -3.844  -23.415 1    16.119  ? 408  GLY   A C   1 
ATOM   3025 O  O   . GLY   A 1  372 ? -16.188 -2.925  -23.803 1    17.85   ? 408  GLY   A O   1 
ATOM   3026 N  N   . PHE   A 1  373 ? -15.9   -4.941  -22.772 1    15.377  ? 409  PHE   A N   1 
ATOM   3027 C  CA  . PHE   A 1  373 ? -17.304 -5.017  -22.401 1    12.913  ? 409  PHE   A CA  1 
ATOM   3028 C  C   . PHE   A 1  373 ? -17.698 -3.932  -21.415 1    15.165  ? 409  PHE   A C   1 
ATOM   3029 O  O   . PHE   A 1  373 ? -18.788 -3.35   -21.511 1    14.388  ? 409  PHE   A O   1 
ATOM   3030 C  CB  . PHE   A 1  373 ? -17.604 -6.315  -21.64  1    14.908  ? 409  PHE   A CB  1 
ATOM   3031 C  CG  . PHE   A 1  373 ? -17.801 -7.474  -22.613 1    17.126  ? 409  PHE   A CG  1 
ATOM   3032 C  CD1 . PHE   A 1  373 ? -16.78  -7.909  -23.454 1    18.018  ? 409  PHE   A CD1 1 
ATOM   3033 C  CD2 . PHE   A 1  373 ? -19.012 -8.185  -22.609 1    18.271  ? 409  PHE   A CD2 1 
ATOM   3034 C  CE1 . PHE   A 1  373 ? -17.018 -8.984  -24.338 1    18.019  ? 409  PHE   A CE1 1 
ATOM   3035 C  CE2 . PHE   A 1  373 ? -19.17  -9.281  -23.438 1    16.062  ? 409  PHE   A CE2 1 
ATOM   3036 C  CZ  . PHE   A 1  373 ? -18.197 -9.634  -24.306 1    17.065  ? 409  PHE   A CZ  1 
ATOM   3037 N  N   . HIS   A 1  374 ? -16.867 -3.658  -20.404 1    16.862  ? 410  HIS   A N   1 
ATOM   3038 C  CA  . HIS   A 1  374 ? -17.163 -2.51   -19.538 1    18.045  ? 410  HIS   A CA  1 
ATOM   3039 C  C   . HIS   A 1  374 ? -17.329 -1.166  -20.263 1    18.446  ? 410  HIS   A C   1 
ATOM   3040 O  O   . HIS   A 1  374 ? -18.243 -0.407  -19.891 1    17.475  ? 410  HIS   A O   1 
ATOM   3041 C  CB  . HIS   A 1  374 ? -16.106 -2.352  -18.428 1    19.012  ? 410  HIS   A CB  1 
ATOM   3042 C  CG  . HIS   A 1  374 ? -16.592 -2.233  -17.007 1    17.767  ? 410  HIS   A CG  1 
ATOM   3043 N  ND1 . HIS   A 1  374 ? -17.317 -1.156  -16.575 1    18.427  ? 410  HIS   A ND1 1 
ATOM   3044 C  CD2 . HIS   A 1  374 ? -16.287 -2.963  -15.892 1    17.884  ? 410  HIS   A CD2 1 
ATOM   3045 C  CE1 . HIS   A 1  374 ? -17.578 -1.295  -15.265 1    18.768  ? 410  HIS   A CE1 1 
ATOM   3046 N  NE2 . HIS   A 1  374 ? -16.934 -2.38   -14.82  1    18.369  ? 410  HIS   A NE2 1 
ATOM   3047 N  N   . GLU   A 1  375 ? -16.472 -0.885  -21.274 1    17.764  ? 411  GLU   A N   1 
ATOM   3048 C  CA  . GLU   A 1  375 ? -16.584 0.365   -22.006 1    16.256  ? 411  GLU   A CA  1 
ATOM   3049 C  C   . GLU   A 1  375 ? -17.841 0.302   -22.905 1    19.833  ? 411  GLU   A C   1 
ATOM   3050 O  O   . GLU   A 1  375 ? -18.4   1.34    -23.252 1    20.546  ? 411  GLU   A O   1 
ATOM   3051 C  CB  . GLU   A 1  375 ? -15.336 0.532   -22.891 1    16.212  ? 411  GLU   A CB  1 
ATOM   3052 C  CG  . GLU   A 1  375 ? -13.992 0.546   -22.142 1    14.914  ? 411  GLU   A CG  1 
ATOM   3053 C  CD  . GLU   A 1  375 ? -14.037 1.61    -21.038 1    17.771  ? 411  GLU   A CD  1 
ATOM   3054 O  OE1 . GLU   A 1  375 ? -14.864 2.553   -21.223 1    16.361  ? 411  GLU   A OE1 1 
ATOM   3055 O  OE2 . GLU   A 1  375 ? -13.412 1.441   -19.952 1    17.097  ? 411  GLU   A OE2 1 
ATOM   3056 N  N   . ALA   A 1  376 ? -18.284 -0.897  -23.342 1    18.51   ? 412  ALA   A N   1 
ATOM   3057 C  CA  . ALA   A 1  376 ? -19.269 -0.952  -24.451 1    17.863  ? 412  ALA   A CA  1 
ATOM   3058 C  C   . ALA   A 1  376 ? -20.698 -0.641  -23.964 1    18.181  ? 412  ALA   A C   1 
ATOM   3059 O  O   . ALA   A 1  376 ? -21.5   -0.115  -24.729 1    19.248  ? 412  ALA   A O   1 
ATOM   3060 C  CB  . ALA   A 1  376 ? -19.202 -2.322  -25.152 1    20.487  ? 412  ALA   A CB  1 
ATOM   3061 N  N   . ILE   A 1  377 ? -21.018 -0.886  -22.674 1    18.46   ? 413  ILE   A N   1 
ATOM   3062 C  CA  . ILE   A 1  377 ? -22.411 -0.959  -22.238 1    17.967  ? 413  ILE   A CA  1 
ATOM   3063 C  C   . ILE   A 1  377 ? -23.093 0.423   -22.46  1    20.221  ? 413  ILE   A C   1 
ATOM   3064 O  O   . ILE   A 1  377 ? -24.203 0.524   -23.082 1    16.212  ? 413  ILE   A O   1 
ATOM   3065 C  CB  . ILE   A 1  377 ? -22.506 -1.356  -20.756 1    17.085  ? 413  ILE   A CB  1 
ATOM   3066 C  CG1 . ILE   A 1  377 ? -21.932 -2.744  -20.467 1    19.261  ? 413  ILE   A CG1 1 
ATOM   3067 C  CG2 . ILE   A 1  377 ? -23.956 -1.205  -20.214 1    19.06   ? 413  ILE   A CG2 1 
ATOM   3068 C  CD1 . ILE   A 1  377 ? -22.464 -3.861  -21.355 1    17.463  ? 413  ILE   A CD1 1 
ATOM   3069 N  N   . GLY   A 1  378 ? -22.492 1.461   -21.856 1    17.015  ? 414  GLY   A N   1 
ATOM   3070 C  CA  . GLY   A 1  378 ? -23.032 2.833   -21.962 1    16.831  ? 414  GLY   A CA  1 
ATOM   3071 C  C   . GLY   A 1  378 ? -23.206 3.26    -23.429 1    20.441  ? 414  GLY   A C   1 
ATOM   3072 O  O   . GLY   A 1  378 ? -24.152 3.968   -23.756 1    21.102  ? 414  GLY   A O   1 
ATOM   3073 N  N   . ASP   A 1  379 ? -22.212 2.954   -24.26  1    18.443  ? 415  ASP   A N   1 
ATOM   3074 C  CA  . ASP   A 1  379 ? -22.147 3.335   -25.673 1    20.486  ? 415  ASP   A CA  1 
ATOM   3075 C  C   . ASP   A 1  379 ? -23.311 2.687   -26.428 1    20.088  ? 415  ASP   A C   1 
ATOM   3076 O  O   . ASP   A 1  379 ? -23.822 3.244   -27.403 1    18.535  ? 415  ASP   A O   1 
ATOM   3077 C  CB  . ASP   A 1  379 ? -20.786 3.014   -26.304 1    15.997  ? 415  ASP   A CB  1 
ATOM   3078 C  CG  . ASP   A 1  379 ? -19.702 4.02    -25.951 1    20.786  ? 415  ASP   A CG  1 
ATOM   3079 O  OD1 . ASP   A 1  379 ? -19.847 4.697   -24.92  1    19.129  ? 415  ASP   A OD1 1 
ATOM   3080 O  OD2 . ASP   A 1  379 ? -18.755 4.17    -26.742 1    22.162  ? 415  ASP   A OD2 1 
ATOM   3081 N  N   . VAL   A 1  380 ? -23.622 1.41    -26.084 1    18.74   ? 416  VAL   A N   1 
ATOM   3082 C  CA  . VAL   A 1  380 ? -24.7   0.703   -26.757 1    18.707  ? 416  VAL   A CA  1 
ATOM   3083 C  C   . VAL   A 1  380 ? -25.995 1.535   -26.539 1    18.642  ? 416  VAL   A C   1 
ATOM   3084 O  O   . VAL   A 1  380 ? -26.607 1.954   -27.52  1    20.1    ? 416  VAL   A O   1 
ATOM   3085 C  CB  . VAL   A 1  380 ? -24.917 -0.713  -26.197 1    22.14   ? 416  VAL   A CB  1 
ATOM   3086 C  CG1 . VAL   A 1  380 ? -26.233 -1.308  -26.693 1    18.954  ? 416  VAL   A CG1 1 
ATOM   3087 C  CG2 . VAL   A 1  380 ? -23.736 -1.624  -26.524 1    20.795  ? 416  VAL   A CG2 1 
ATOM   3088 N  N   . LEU   A 1  381 ? -26.326 1.884   -25.295 1    14.9    ? 417  LEU   A N   1 
ATOM   3089 C  CA  . LEU   A 1  381 ? -27.489 2.733   -25.081 1    19.707  ? 417  LEU   A CA  1 
ATOM   3090 C  C   . LEU   A 1  381 ? -27.4   4.032   -25.866 1    19.81   ? 417  LEU   A C   1 
ATOM   3091 O  O   . LEU   A 1  381 ? -28.392 4.537   -26.411 1    18.541  ? 417  LEU   A O   1 
ATOM   3092 C  CB  . LEU   A 1  381 ? -27.719 3.003   -23.589 1    16.729  ? 417  LEU   A CB  1 
ATOM   3093 C  CG  . LEU   A 1  381 ? -28.538 1.873   -22.932 1    16.993  ? 417  LEU   A CG  1 
ATOM   3094 C  CD1 . LEU   A 1  381 ? -27.862 0.457   -22.986 1    18.417  ? 417  LEU   A CD1 1 
ATOM   3095 C  CD2 . LEU   A 1  381 ? -28.899 2.283   -21.527 1    14.931  ? 417  LEU   A CD2 1 
ATOM   3096 N  N   . ALA   A 1  382 ? -26.238 4.646   -25.787 1    17.885  ? 418  ALA   A N   1 
ATOM   3097 C  CA  . ALA   A 1  382 ? -26.046 5.989   -26.369 1    16.27   ? 418  ALA   A CA  1 
ATOM   3098 C  C   . ALA   A 1  382 ? -26.192 5.914   -27.889 1    16.087  ? 418  ALA   A C   1 
ATOM   3099 O  O   . ALA   A 1  382 ? -26.572 6.898   -28.545 1    16.202  ? 418  ALA   A O   1 
ATOM   3100 C  CB  . ALA   A 1  382 ? -24.657 6.53    -25.983 1    15.197  ? 418  ALA   A CB  1 
ATOM   3101 N  N   . LEU   A 1  383 ? -25.994 4.725   -28.501 1    15.381  ? 419  LEU   A N   1 
ATOM   3102 C  CA  . LEU   A 1  383 ? -26.318 4.685   -29.939 1    16.856  ? 419  LEU   A CA  1 
ATOM   3103 C  C   . LEU   A 1  383 ? -27.825 4.914   -30.141 1    18.552  ? 419  LEU   A C   1 
ATOM   3104 O  O   . LEU   A 1  383 ? -28.199 5.583   -31.104 1    20.34   ? 419  LEU   A O   1 
ATOM   3105 C  CB  . LEU   A 1  383 ? -25.92  3.31    -30.471 1    18.376  ? 419  LEU   A CB  1 
ATOM   3106 C  CG  . LEU   A 1  383 ? -24.413 3.036   -30.656 1    19.918  ? 419  LEU   A CG  1 
ATOM   3107 C  CD1 . LEU   A 1  383 ? -24.284 1.573   -31.02  1    18.851  ? 419  LEU   A CD1 1 
ATOM   3108 C  CD2 . LEU   A 1  383 ? -23.86  3.833   -31.843 1    19.424  ? 419  LEU   A CD2 1 
ATOM   3109 N  N   . SER   A 1  384 ? -28.671 4.327   -29.294 1    17.657  ? 420  SER   A N   1 
ATOM   3110 C  CA  . SER   A 1  384 ? -30.129 4.561   -29.442 1    19.562  ? 420  SER   A CA  1 
ATOM   3111 C  C   . SER   A 1  384 ? -30.483 6.011   -29.066 1    21.121  ? 420  SER   A C   1 
ATOM   3112 O  O   . SER   A 1  384 ? -31.295 6.64    -29.748 1    23.063  ? 420  SER   A O   1 
ATOM   3113 C  CB  . SER   A 1  384 ? -30.954 3.571   -28.655 1    17.401  ? 420  SER   A CB  1 
ATOM   3114 O  OG  . SER   A 1  384 ? -30.857 2.314   -29.333 1    18.572  ? 420  SER   A OG  1 
ATOM   3115 N  N   . VAL   A 1  385 ? -29.812 6.578   -28.035 1    19.125  ? 421  VAL   A N   1 
ATOM   3116 C  CA  . VAL   A 1  385 ? -30.043 7.958   -27.585 1    21.168  ? 421  VAL   A CA  1 
ATOM   3117 C  C   . VAL   A 1  385 ? -29.827 8.925   -28.753 1    21.443  ? 421  VAL   A C   1 
ATOM   3118 O  O   . VAL   A 1  385 ? -30.537 9.92    -28.837 1    20.335  ? 421  VAL   A O   1 
ATOM   3119 C  CB  . VAL   A 1  385 ? -29.1   8.306   -26.422 1    22.481  ? 421  VAL   A CB  1 
ATOM   3120 C  CG1 . VAL   A 1  385 ? -29.004 9.802   -26.144 1    23.67   ? 421  VAL   A CG1 1 
ATOM   3121 C  CG2 . VAL   A 1  385 ? -29.476 7.55    -25.136 1    26.679  ? 421  VAL   A CG2 1 
ATOM   3122 N  N   . SER   A 1  386 ? -28.775 8.677   -29.573 1    25.199  ? 422  SER   A N   1 
ATOM   3123 C  CA  . SER   A 1  386 ? -28.332 9.542   -30.675 1    23.215  ? 422  SER   A CA  1 
ATOM   3124 C  C   . SER   A 1  386 ? -29.267 9.518   -31.879 1    26.809  ? 422  SER   A C   1 
ATOM   3125 O  O   . SER   A 1  386 ? -29.17  10.439  -32.734 1    22.255  ? 422  SER   A O   1 
ATOM   3126 C  CB  . SER   A 1  386 ? -26.882 9.201   -31.135 1    25.788  ? 422  SER   A CB  1 
ATOM   3127 O  OG  . SER   A 1  386 ? -26.056 9.276   -29.982 1    26.799  ? 422  SER   A OG  1 
ATOM   3128 N  N   . THR   A 1  387 ? -30.134 8.473   -31.969 1    18.414  ? 423  THR   A N   1 
ATOM   3129 C  CA  . THR   A 1  387 ? -30.99  8.445   -33.15  1    18.128  ? 423  THR   A CA  1 
ATOM   3130 C  C   . THR   A 1  387 ? -31.839 9.716   -33.182 1    22.066  ? 423  THR   A C   1 
ATOM   3131 O  O   . THR   A 1  387 ? -32.356 10.175  -32.149 1    20.643  ? 423  THR   A O   1 
ATOM   3132 C  CB  . THR   A 1  387 ? -31.925 7.208   -33.208 1    21.053  ? 423  THR   A CB  1 
ATOM   3133 O  OG1 . THR   A 1  387 ? -32.708 7.298   -32.004 1    21.268  ? 423  THR   A OG1 1 
ATOM   3134 C  CG2 . THR   A 1  387 ? -31.167 5.889   -33.212 1    24.07   ? 423  THR   A CG2 1 
ATOM   3135 N  N   . PRO   A 1  388 ? -32.201 10.177  -34.418 1    24.231  ? 424  PRO   A N   1 
ATOM   3136 C  CA  . PRO   A 1  388 ? -33.232 11.201  -34.603 1    26.073  ? 424  PRO   A CA  1 
ATOM   3137 C  C   . PRO   A 1  388 ? -34.545 10.954  -33.875 1    27.308  ? 424  PRO   A C   1 
ATOM   3138 O  O   . PRO   A 1  388 ? -35.047 11.868  -33.211 1    31.018  ? 424  PRO   A O   1 
ATOM   3139 C  CB  . PRO   A 1  388 ? -33.385 11.161  -36.169 1    25.089  ? 424  PRO   A CB  1 
ATOM   3140 C  CG  . PRO   A 1  388 ? -31.939 10.845  -36.622 1    31.591  ? 424  PRO   A CG  1 
ATOM   3141 C  CD  . PRO   A 1  388 ? -31.683 9.655   -35.697 1    25.456  ? 424  PRO   A CD  1 
ATOM   3142 N  N   . LYS   A 1  389 ? -34.99  9.677   -33.868 1    24.329  ? 425  LYS   A N   1 
ATOM   3143 C  CA  . LYS   A 1  389 ? -36.197 9.3     -33.132 1    26.771  ? 425  LYS   A CA  1 
ATOM   3144 C  C   . LYS   A 1  389 ? -36.075 9.68    -31.664 1    26.651  ? 425  LYS   A C   1 
ATOM   3145 O  O   . LYS   A 1  389 ? -36.948 10.307  -31.034 1    25.343  ? 425  LYS   A O   1 
ATOM   3146 C  CB  . LYS   A 1  389 ? -36.446 7.787   -33.235 1    23.526  ? 425  LYS   A CB  1 
ATOM   3147 C  CG  . LYS   A 1  389 ? -37.577 7.375   -32.273 1    32.73   ? 425  LYS   A CG  1 
ATOM   3148 C  CD  . LYS   A 1  389 ? -37.924 5.902   -32.462 1    37.402  ? 425  LYS   A CD  1 
ATOM   3149 C  CE  . LYS   A 1  389 ? -39.224 5.617   -31.805 1    41.387  ? 425  LYS   A CE  1 
ATOM   3150 N  NZ  . LYS   A 1  389 ? -39.514 4.196   -31.974 1    38.576  ? 425  LYS   A NZ  1 
ATOM   3151 N  N   . HIS   A 1  390 ? -34.941 9.34    -31.046 1    24.351  ? 426  HIS   A N   1 
ATOM   3152 C  CA  . HIS   A 1  390 ? -34.914 9.624   -29.615 1    21.883  ? 426  HIS   A CA  1 
ATOM   3153 C  C   . HIS   A 1  390 ? -34.59  11.104  -29.38  1    20.523  ? 426  HIS   A C   1 
ATOM   3154 O  O   . HIS   A 1  390 ? -35.038 11.603  -28.363 1    20.527  ? 426  HIS   A O   1 
ATOM   3155 C  CB  . HIS   A 1  390 ? -33.929 8.712   -28.88  1    20.25   ? 426  HIS   A CB  1 
ATOM   3156 C  CG  . HIS   A 1  390 ? -33.908 8.908   -27.41  1    25.316  ? 426  HIS   A CG  1 
ATOM   3157 N  ND1 . HIS   A 1  390 ? -34.714 8.168   -26.566 1    25.178  ? 426  HIS   A ND1 1 
ATOM   3158 C  CD2 . HIS   A 1  390 ? -33.122 9.656   -26.588 1    25.251  ? 426  HIS   A CD2 1 
ATOM   3159 C  CE1 . HIS   A 1  390 ? -34.472 8.536   -25.293 1    26.264  ? 426  HIS   A CE1 1 
ATOM   3160 N  NE2 . HIS   A 1  390 ? -33.51  9.448   -25.306 1    26.384  ? 426  HIS   A NE2 1 
ATOM   3161 N  N   . LEU   A 1  391 ? -33.691 11.718  -30.201 1    24.297  ? 427  LEU   A N   1 
ATOM   3162 C  CA  . LEU   A 1  391 ? -33.322 13.121  -29.944 1    21.912  ? 427  LEU   A CA  1 
ATOM   3163 C  C   . LEU   A 1  391 ? -34.555 14.007  -30.165 1    24.163  ? 427  LEU   A C   1 
ATOM   3164 O  O   . LEU   A 1  391 ? -34.819 14.894  -29.371 1    27.484  ? 427  LEU   A O   1 
ATOM   3165 C  CB  . LEU   A 1  391 ? -32.154 13.55   -30.839 1    22.614  ? 427  LEU   A CB  1 
ATOM   3166 C  CG  . LEU   A 1  391 ? -30.81  12.861  -30.541 1    30.786  ? 427  LEU   A CG  1 
ATOM   3167 C  CD1 . LEU   A 1  391 ? -29.789 13.339  -31.573 1    28.577  ? 427  LEU   A CD1 1 
ATOM   3168 C  CD2 . LEU   A 1  391 ? -30.418 13.245  -29.101 1    25.603  ? 427  LEU   A CD2 1 
ATOM   3169 N  N   . HIS   A 1  392 ? -35.337 13.662  -31.213 1    22.832  ? 428  HIS   A N   1 
ATOM   3170 C  CA  . HIS   A 1  392 ? -36.642 14.288  -31.445 1    30.931  ? 428  HIS   A CA  1 
ATOM   3171 C  C   . HIS   A 1  392 ? -37.462 14.245  -30.157 1    27.587  ? 428  HIS   A C   1 
ATOM   3172 O  O   . HIS   A 1  392 ? -37.898 15.28   -29.675 1    29.977  ? 428  HIS   A O   1 
ATOM   3173 C  CB  . HIS   A 1  392 ? -37.348 13.813  -32.735 1    34.889  ? 428  HIS   A CB  1 
ATOM   3174 C  CG  . HIS   A 1  392 ? -38.632 14.569  -32.837 1    41.911  ? 428  HIS   A CG  1 
ATOM   3175 N  ND1 . HIS   A 1  392 ? -38.644 15.928  -33.139 1    44.613  ? 428  HIS   A ND1 1 
ATOM   3176 C  CD2 . HIS   A 1  392 ? -39.909 14.237  -32.537 1    51.484  ? 428  HIS   A CD2 1 
ATOM   3177 C  CE1 . HIS   A 1  392 ? -39.902 16.388  -33.105 1    53.618  ? 428  HIS   A CE1 1 
ATOM   3178 N  NE2 . HIS   A 1  392 ? -40.69  15.388  -32.725 1    50.294  ? 428  HIS   A NE2 1 
ATOM   3179 N  N   . SER   A 1  393 ? -37.522 13.081  -29.486 1    26.649  ? 429  SER   A N   1 
ATOM   3180 C  CA  . SER   A 1  393 ? -38.348 12.925  -28.314 1    28.019  ? 429  SER   A CA  1 
ATOM   3181 C  C   . SER   A 1  393 ? -37.874 13.786  -27.154 1    34.152  ? 429  SER   A C   1 
ATOM   3182 O  O   . SER   A 1  393 ? -38.653 14.109  -26.267 1    30.087  ? 429  SER   A O   1 
ATOM   3183 C  CB  . SER   A 1  393 ? -38.44  11.44   -27.942 1    25.522  ? 429  SER   A CB  1 
ATOM   3184 O  OG  . SER   A 1  393 ? -37.3   10.982  -27.216 1    33.254  ? 429  SER   A OG  1 
ATOM   3185 N  N   . LEU   A 1  394 ? -36.574 14.137  -27.144 1    30.136  ? 430  LEU   A N   1 
ATOM   3186 C  CA  . LEU   A 1  394 ? -36.055 14.881  -26.024 1    28.516  ? 430  LEU   A CA  1 
ATOM   3187 C  C   . LEU   A 1  394 ? -36.111 16.355  -26.401 1    31.498  ? 430  LEU   A C   1 
ATOM   3188 O  O   . LEU   A 1  394 ? -35.513 17.193  -25.734 1    33.393  ? 430  LEU   A O   1 
ATOM   3189 C  CB  . LEU   A 1  394 ? -34.59  14.478  -25.828 1    27.916  ? 430  LEU   A CB  1 
ATOM   3190 C  CG  . LEU   A 1  394 ? -34.307 13.104  -25.215 1    25.885  ? 430  LEU   A CG  1 
ATOM   3191 C  CD1 . LEU   A 1  394 ? -32.832 12.868  -25.344 1    25.741  ? 430  LEU   A CD1 1 
ATOM   3192 C  CD2 . LEU   A 1  394 ? -34.609 12.938  -23.718 1    32.398  ? 430  LEU   A CD2 1 
ATOM   3193 N  N   . ASN   A 1  395 ? -36.66  16.635  -27.574 1    32.301  ? 431  ASN   A N   1 
ATOM   3194 C  CA  . ASN   A 1  395 ? -36.794 17.995  -28.08  1    39.379  ? 431  ASN   A CA  1 
ATOM   3195 C  C   . ASN   A 1  395 ? -35.476 18.655  -28.521 1    35.59   ? 431  ASN   A C   1 
ATOM   3196 O  O   . ASN   A 1  395 ? -35.337 19.889  -28.453 1    33.722  ? 431  ASN   A O   1 
ATOM   3197 C  CB  . ASN   A 1  395 ? -37.444 18.909  -27.045 1    37.3    ? 431  ASN   A CB  1 
ATOM   3198 C  CG  . ASN   A 1  395 ? -38.333 19.915  -27.753 1    39.278  ? 431  ASN   A CG  1 
ATOM   3199 O  OD1 . ASN   A 1  395 ? -38.553 19.83   -28.971 1    39.036  ? 431  ASN   A OD1 1 
ATOM   3200 N  ND2 . ASN   A 1  395 ? -38.809 20.913  -27.023 1    40.711  ? 431  ASN   A ND2 1 
ATOM   3201 N  N   . LEU   A 1  396 ? -34.567 17.858  -29.08  1    26.558  ? 432  LEU   A N   1 
ATOM   3202 C  CA  . LEU   A 1  396 ? -33.243 18.329  -29.449 1    27.895  ? 432  LEU   A CA  1 
ATOM   3203 C  C   . LEU   A 1  396 ? -33.062 18.283  -30.957 1    28.489  ? 432  LEU   A C   1 
ATOM   3204 O  O   . LEU   A 1  396 ? -32.099 18.84   -31.444 1    36.304  ? 432  LEU   A O   1 
ATOM   3205 C  CB  . LEU   A 1  396 ? -32.171 17.546  -28.666 1    24.921  ? 432  LEU   A CB  1 
ATOM   3206 C  CG  . LEU   A 1  396 ? -32.272 17.582  -27.121 1    22.492  ? 432  LEU   A CG  1 
ATOM   3207 C  CD1 . LEU   A 1  396 ? -31.085 16.825  -26.454 1    24.709  ? 432  LEU   A CD1 1 
ATOM   3208 C  CD2 . LEU   A 1  396 ? -32.352 18.992  -26.574 1    23.944  ? 432  LEU   A CD2 1 
ATOM   3209 N  N   . LEU   A 1  397 ? -33.942 17.554  -31.693 1    32.071  ? 433  LEU   A N   1 
ATOM   3210 C  CA  . LEU   A 1  397 ? -34.071 17.59   -33.153 1    36.289  ? 433  LEU   A CA  1 
ATOM   3211 C  C   . LEU   A 1  397 ? -35.562 17.838  -33.488 1    45.385  ? 433  LEU   A C   1 
ATOM   3212 O  O   . LEU   A 1  397 ? -36.429 17.718  -32.61  1    44.052  ? 433  LEU   A O   1 
ATOM   3213 C  CB  . LEU   A 1  397 ? -33.526 16.386  -33.971 1    42.02   ? 433  LEU   A CB  1 
ATOM   3214 C  CG  . LEU   A 1  397 ? -32.032 15.993  -33.883 1    43.78   ? 433  LEU   A CG  1 
ATOM   3215 C  CD1 . LEU   A 1  397 ? -31.65  14.733  -34.702 1    42.609  ? 433  LEU   A CD1 1 
ATOM   3216 C  CD2 . LEU   A 1  397 ? -30.948 17.066  -34.107 1    47.132  ? 433  LEU   A CD2 1 
ATOM   3217 N  N   . SER   A 1  398 ? -35.852 18.205  -34.756 1    51.294  ? 434  SER   A N   1 
ATOM   3218 C  CA  . SER   A 1  398 ? -37.173 18.114  -35.395 1    51.891  ? 434  SER   A CA  1 
ATOM   3219 C  C   . SER   A 1  398 ? -37.147 17.05   -36.513 1    51.872  ? 434  SER   A C   1 
ATOM   3220 O  O   . SER   A 1  398 ? -38.136 16.31   -36.66  1    53.085  ? 434  SER   A O   1 
ATOM   3221 C  CB  . SER   A 1  398 ? -37.591 19.47   -35.903 1    53.451  ? 434  SER   A CB  1 
ATOM   3222 O  OG  . SER   A 1  398 ? -36.453 20.204  -36.348 1    43.914  ? 434  SER   A OG  1 
ATOM   3223 N  N   . SER   A 1  403 ? -36.36  11.72   -44.64  1    43.526  ? 439  SER   A N   1 
ATOM   3224 C  CA  . SER   A 1  403 ? -35.7   11.839  -45.983 1    41.268  ? 439  SER   A CA  1 
ATOM   3225 C  C   . SER   A 1  403 ? -34.412 11.021  -46.012 1    41.759  ? 439  SER   A C   1 
ATOM   3226 O  O   . SER   A 1  403 ? -33.8   10.803  -44.954 1    41.439  ? 439  SER   A O   1 
ATOM   3227 C  CB  . SER   A 1  403 ? -35.4   13.262  -46.368 1    47.522  ? 439  SER   A CB  1 
ATOM   3228 O  OG  . SER   A 1  403 ? -34.615 13.912  -45.368 1    43.812  ? 439  SER   A OG  1 
ATOM   3229 N  N   . ASP   A 1  404 ? -34.043 10.553  -47.224 1    36.378  ? 440  ASP   A N   1 
ATOM   3230 C  CA  . ASP   A 1  404 ? -32.727 9.995   -47.508 1    40.497  ? 440  ASP   A CA  1 
ATOM   3231 C  C   . ASP   A 1  404 ? -31.678 11.027  -47.064 1    39.08   ? 440  ASP   A C   1 
ATOM   3232 O  O   . ASP   A 1  404 ? -30.616 10.655  -46.575 1    31.718  ? 440  ASP   A O   1 
ATOM   3233 C  CB  . ASP   A 1  404 ? -32.536 9.481   -48.938 1    41.107  ? 440  ASP   A CB  1 
ATOM   3234 C  CG  . ASP   A 1  404 ? -31.14  8.923   -49.279 1    67.775  ? 440  ASP   A CG  1 
ATOM   3235 O  OD1 . ASP   A 1  404 ? -30.735 7.938   -48.599 1    77.842  ? 440  ASP   A OD1 1 
ATOM   3236 O  OD2 . ASP   A 1  404 ? -30.416 9.469   -50.208 1    60.071  ? 440  ASP   A OD2 1 
ATOM   3237 N  N   . GLU   A 1  405 ? -31.976 12.32   -47.247 1    31.017  ? 441  GLU   A N   1 
ATOM   3238 C  CA  . GLU   A 1  405 ? -30.966 13.327  -47     1    36.911  ? 441  GLU   A CA  1 
ATOM   3239 C  C   . GLU   A 1  405 ? -30.606 13.335  -45.509 1    33.805  ? 441  GLU   A C   1 
ATOM   3240 O  O   . GLU   A 1  405 ? -29.417 13.275  -45.151 1    31.887  ? 441  GLU   A O   1 
ATOM   3241 C  CB  . GLU   A 1  405 ? -31.459 14.644  -47.598 1    41.384  ? 441  GLU   A CB  1 
ATOM   3242 C  CG  . GLU   A 1  405 ? -31.782 14.426  -49.074 1    59.151  ? 441  GLU   A CG  1 
ATOM   3243 C  CD  . GLU   A 1  405 ? -31.638 15.711  -49.841 1    75.619  ? 441  GLU   A CD  1 
ATOM   3244 O  OE1 . GLU   A 1  405 ? -31.711 16.802  -49.225 1    73.206  ? 441  GLU   A OE1 1 
ATOM   3245 O  OE2 . GLU   A 1  405 ? -31.396 15.596  -51.063 1    92.834  ? 441  GLU   A OE2 1 
ATOM   3246 N  N   . HIS   A 1  406 ? -31.629 13.465  -44.653 1    32.279  ? 442  HIS   A N   1 
ATOM   3247 C  CA  . HIS   A 1  406 ? -31.409 13.499  -43.223 1    33.185  ? 442  HIS   A CA  1 
ATOM   3248 C  C   . HIS   A 1  406 ? -30.749 12.161  -42.828 1    30.551  ? 442  HIS   A C   1 
ATOM   3249 O  O   . HIS   A 1  406 ? -29.957 12.078  -41.901 1    26.938  ? 442  HIS   A O   1 
ATOM   3250 C  CB  . HIS   A 1  406 ? -32.765 13.617  -42.514 1    34.118  ? 442  HIS   A CB  1 
ATOM   3251 C  CG  . HIS   A 1  406 ? -33.393 14.978  -42.513 1    45.924  ? 442  HIS   A CG  1 
ATOM   3252 N  ND1 . HIS   A 1  406 ? -32.816 16.088  -41.915 1    54.375  ? 442  HIS   A ND1 1 
ATOM   3253 C  CD2 . HIS   A 1  406 ? -34.558 15.41   -43.046 1    43.056  ? 442  HIS   A CD2 1 
ATOM   3254 C  CE1 . HIS   A 1  406 ? -33.615 17.149  -42.066 1    46.612  ? 442  HIS   A CE1 1 
ATOM   3255 N  NE2 . HIS   A 1  406 ? -34.663 16.753  -42.753 1    42.819  ? 442  HIS   A NE2 1 
ATOM   3256 N  N   . ASP   A 1  407 ? -31.086 11.083  -43.538 1    27.345  ? 443  ASP   A N   1 
ATOM   3257 C  CA  . ASP   A 1  407 ? -30.561 9.802   -43.119 1    29.325  ? 443  ASP   A CA  1 
ATOM   3258 C  C   . ASP   A 1  407 ? -29.023 9.747   -43.236 1    30.063  ? 443  ASP   A C   1 
ATOM   3259 O  O   . ASP   A 1  407 ? -28.32  9.252   -42.331 1    22.607  ? 443  ASP   A O   1 
ATOM   3260 C  CB  . ASP   A 1  407 ? -31.299 8.726   -43.871 1    32.357  ? 443  ASP   A CB  1 
ATOM   3261 C  CG  . ASP   A 1  407 ? -31.042 7.344   -43.327 1    34.091  ? 443  ASP   A CG  1 
ATOM   3262 O  OD1 . ASP   A 1  407 ? -31.281 7.156   -42.129 1    40.263  ? 443  ASP   A OD1 1 
ATOM   3263 O  OD2 . ASP   A 1  407 ? -30.618 6.489   -44.107 1    41.447  ? 443  ASP   A OD2 1 
ATOM   3264 N  N   . ILE   A 1  408 ? -28.521 10.133  -44.415 1    25.173  ? 444  ILE   A N   1 
ATOM   3265 C  CA  . ILE   A 1  408 ? -27.09  10.146  -44.756 1    21.343  ? 444  ILE   A CA  1 
ATOM   3266 C  C   . ILE   A 1  408 ? -26.438 11.191  -43.862 1    21.132  ? 444  ILE   A C   1 
ATOM   3267 O  O   . ILE   A 1  408 ? -25.321 10.947  -43.362 1    19.842  ? 444  ILE   A O   1 
ATOM   3268 C  CB  . ILE   A 1  408 ? -26.821 10.441  -46.26  1    20.704  ? 444  ILE   A CB  1 
ATOM   3269 C  CG1 . ILE   A 1  408 ? -27.155 9.305   -47.195 1    22.348  ? 444  ILE   A CG1 1 
ATOM   3270 C  CG2 . ILE   A 1  408 ? -25.403 10.958  -46.499 1    18.975  ? 444  ILE   A CG2 1 
ATOM   3271 C  CD1 . ILE   A 1  408 ? -26.867 7.897   -46.693 1    25.335  ? 444  ILE   A CD1 1 
ATOM   3272 N  N   . ASN   A 1  409 ? -27.141 12.311  -43.563 1    20.487  ? 445  ASN   A N   1 
ATOM   3273 C  CA  . ASN   A 1  409 ? -26.539 13.242  -42.62  1    26.551  ? 445  ASN   A CA  1 
ATOM   3274 C  C   . ASN   A 1  409 ? -26.345 12.583  -41.239 1    27.095  ? 445  ASN   A C   1 
ATOM   3275 O  O   . ASN   A 1  409 ? -25.35  12.844  -40.563 1    24.362  ? 445  ASN   A O   1 
ATOM   3276 C  CB  . ASN   A 1  409 ? -27.288 14.554  -42.427 1    21.769  ? 445  ASN   A CB  1 
ATOM   3277 C  CG  . ASN   A 1  409 ? -27.248 15.46   -43.655 1    24.96   ? 445  ASN   A CG  1 
ATOM   3278 O  OD1 . ASN   A 1  409 ? -26.484 15.223  -44.592 1    24.87   ? 445  ASN   A OD1 1 
ATOM   3279 N  ND2 . ASN   A 1  409 ? -28.072 16.506  -43.683 1    23.024  ? 445  ASN   A ND2 1 
ATOM   3280 N  N   . PHE   A 1  410 ? -27.378 11.928  -40.701 1    20.754  ? 446  PHE   A N   1 
ATOM   3281 C  CA  . PHE   A 1  410 ? -27.214 11.34   -39.379 1    21.147  ? 446  PHE   A CA  1 
ATOM   3282 C  C   . PHE   A 1  410 ? -26.076 10.301  -39.414 1    19.799  ? 446  PHE   A C   1 
ATOM   3283 O  O   . PHE   A 1  410 ? -25.267 10.206  -38.502 1    19.58   ? 446  PHE   A O   1 
ATOM   3284 C  CB  . PHE   A 1  410 ? -28.524 10.626  -39.064 1    17.495  ? 446  PHE   A CB  1 
ATOM   3285 C  CG  . PHE   A 1  410 ? -28.422 9.622   -37.921 1    18.446  ? 446  PHE   A CG  1 
ATOM   3286 C  CD1 . PHE   A 1  410 ? -28.192 10.081  -36.622 1    21.652  ? 446  PHE   A CD1 1 
ATOM   3287 C  CD2 . PHE   A 1  410 ? -28.487 8.239   -38.149 1    19.585  ? 446  PHE   A CD2 1 
ATOM   3288 C  CE1 . PHE   A 1  410 ? -28.028 9.218   -35.559 1    21.044  ? 446  PHE   A CE1 1 
ATOM   3289 C  CE2 . PHE   A 1  410 ? -28.341 7.361   -37.062 1    21.724  ? 446  PHE   A CE2 1 
ATOM   3290 C  CZ  . PHE   A 1  410 ? -28.157 7.871   -35.775 1    20.55   ? 446  PHE   A CZ  1 
ATOM   3291 N  N   . LEU   A 1  411 ? -26.007 9.456   -40.463 1    19.179  ? 447  LEU   A N   1 
ATOM   3292 C  CA  . LEU   A 1  411 ? -24.961 8.453   -40.53  1    18.582  ? 447  LEU   A CA  1 
ATOM   3293 C  C   . LEU   A 1  411 ? -23.6   9.181   -40.567 1    22.614  ? 447  LEU   A C   1 
ATOM   3294 O  O   . LEU   A 1  411 ? -22.616 8.684   -39.982 1    20.438  ? 447  LEU   A O   1 
ATOM   3295 C  CB  . LEU   A 1  411 ? -25.076 7.522   -41.751 1    21.195  ? 447  LEU   A CB  1 
ATOM   3296 C  CG  . LEU   A 1  411 ? -26.183 6.472   -41.641 1    23.619  ? 447  LEU   A CG  1 
ATOM   3297 C  CD1 . LEU   A 1  411 ? -26.305 5.735   -42.951 1    23.615  ? 447  LEU   A CD1 1 
ATOM   3298 C  CD2 . LEU   A 1  411 ? -25.791 5.537   -40.457 1    25.199  ? 447  LEU   A CD2 1 
ATOM   3299 N  N   . MET   A 1  412 ? -23.533 10.345  -41.269 1    17.19   ? 448  MET   A N   1 
ATOM   3300 C  CA  . MET   A 1  412 ? -22.259 11.089  -41.303 1    18.458  ? 448  MET   A CA  1 
ATOM   3301 C  C   . MET   A 1  412 ? -21.897 11.514  -39.857 1    20.252  ? 448  MET   A C   1 
ATOM   3302 O  O   . MET   A 1  412 ? -20.745 11.389  -39.399 1    19.665  ? 448  MET   A O   1 
ATOM   3303 C  CB  . MET   A 1  412 ? -22.26  12.293  -42.277 1    20.921  ? 448  MET   A CB  1 
ATOM   3304 C  CG  . MET   A 1  412 ? -20.971 13.177  -42.184 1    20.458  ? 448  MET   A CG  1 
ATOM   3305 S  SD  . MET   A 1  412 ? -19.594 12.119  -42.668 1    26.981  ? 448  MET   A SD  1 
ATOM   3306 C  CE  . MET   A 1  412 ? -19.769 11.702  -44.391 1    19.944  ? 448  MET   A CE  1 
ATOM   3307 N  N   . LYS   A 1  413 ? -22.862 12.126  -39.18  1    18.928  ? 449  LYS   A N   1 
ATOM   3308 C  CA  . LYS   A 1  413 ? -22.665 12.531  -37.803 1    21.998  ? 449  LYS   A CA  1 
ATOM   3309 C  C   . LYS   A 1  413 ? -22.185 11.37   -36.945 1    21.66   ? 449  LYS   A C   1 
ATOM   3310 O  O   . LYS   A 1  413 ? -21.254 11.531  -36.186 1    20.118  ? 449  LYS   A O   1 
ATOM   3311 C  CB  . LYS   A 1  413 ? -23.923 13.245  -37.296 1    21.131  ? 449  LYS   A CB  1 
ATOM   3312 C  CG  . LYS   A 1  413 ? -23.703 13.518  -35.83  1    28.031  ? 449  LYS   A CG  1 
ATOM   3313 C  CD  . LYS   A 1  413 ? -22.85  14.795  -35.714 1    31.479  ? 449  LYS   A CD  1 
ATOM   3314 C  CE  . LYS   A 1  413 ? -22.447 15.264  -34.282 1    35.51   ? 449  LYS   A CE  1 
ATOM   3315 N  NZ  . LYS   A 1  413 ? -23.498 15.28   -33.243 1    30.288  ? 449  LYS   A NZ  1 
ATOM   3316 N  N   . MET   A 1  414 ? -22.733 10.153  -37.122 1    19.876  ? 450  MET   A N   1 
ATOM   3317 C  CA  . MET   A 1  414 ? -22.298 9.013   -36.316 1    17.3    ? 450  MET   A CA  1 
ATOM   3318 C  C   . MET   A 1  414 ? -20.882 8.547   -36.713 1    18.976  ? 450  MET   A C   1 
ATOM   3319 O  O   . MET   A 1  414 ? -20.123 8.116   -35.84  1    18.521  ? 450  MET   A O   1 
ATOM   3320 C  CB  . MET   A 1  414 ? -23.272 7.816   -36.429 1    16.974  ? 450  MET   A CB  1 
ATOM   3321 C  CG  . MET   A 1  414 ? -24.679 8.096   -35.889 1    18.566  ? 450  MET   A CG  1 
ATOM   3322 S  SD  . MET   A 1  414 ? -24.654 8.64    -34.138 1    31.007  ? 450  MET   A SD  1 
ATOM   3323 C  CE  . MET   A 1  414 ? -23.845 7.184   -33.501 1    18.41   ? 450  MET   A CE  1 
ATOM   3324 N  N   . ALA   A 1  415 ? -20.587 8.5     -38.026 1    18.861  ? 451  ALA   A N   1 
ATOM   3325 C  CA  . ALA   A 1  415 ? -19.298 8.066   -38.563 1    17.966  ? 451  ALA   A CA  1 
ATOM   3326 C  C   . ALA   A 1  415 ? -18.153 8.99    -38.079 1    19.858  ? 451  ALA   A C   1 
ATOM   3327 O  O   . ALA   A 1  415 ? -17.119 8.454   -37.708 1    15.74   ? 451  ALA   A O   1 
ATOM   3328 C  CB  . ALA   A 1  415 ? -19.3   7.984   -40.081 1    17.157  ? 451  ALA   A CB  1 
ATOM   3329 N  N   . LEU   A 1  416 ? -18.38  10.325  -37.982 1    16.646  ? 452  LEU   A N   1 
ATOM   3330 C  CA  . LEU   A 1  416 ? -17.382 11.285  -37.494 1    20.023  ? 452  LEU   A CA  1 
ATOM   3331 C  C   . LEU   A 1  416 ? -16.942 10.947  -36.056 1    19.037  ? 452  LEU   A C   1 
ATOM   3332 O  O   . LEU   A 1  416 ? -15.796 11.131  -35.731 1    22.62   ? 452  LEU   A O   1 
ATOM   3333 C  CB  . LEU   A 1  416 ? -17.844 12.748  -37.599 1    17.9    ? 452  LEU   A CB  1 
ATOM   3334 C  CG  . LEU   A 1  416 ? -18.156 13.267  -39.023 1    17.378  ? 452  LEU   A CG  1 
ATOM   3335 C  CD1 . LEU   A 1  416 ? -18.791 14.654  -38.805 1    14.785  ? 452  LEU   A CD1 1 
ATOM   3336 C  CD2 . LEU   A 1  416 ? -16.847 13.369  -39.826 1    18.619  ? 452  LEU   A CD2 1 
ATOM   3337 N  N   . ASP   A 1  417 ? -17.849 10.437  -35.229 1    19.182  ? 453  ASP   A N   1 
ATOM   3338 C  CA  . ASP   A 1  417 ? -17.501 9.925   -33.893 1    24.147  ? 453  ASP   A CA  1 
ATOM   3339 C  C   . ASP   A 1  417 ? -17.001 8.462   -33.969 1    24.014  ? 453  ASP   A C   1 
ATOM   3340 O  O   . ASP   A 1  417 ? -15.832 8.159   -33.777 1    25.291  ? 453  ASP   A O   1 
ATOM   3341 C  CB  . ASP   A 1  417 ? -18.579 10.31   -32.892 1    28.837  ? 453  ASP   A CB  1 
ATOM   3342 C  CG  . ASP   A 1  417 ? -18.363 9.67    -31.523 1    56.909  ? 453  ASP   A CG  1 
ATOM   3343 O  OD1 . ASP   A 1  417 ? -17.178 9.518   -31.111 1    62.292  ? 453  ASP   A OD1 1 
ATOM   3344 O  OD2 . ASP   A 1  417 ? -19.369 9.277   -30.877 1    71.881  ? 453  ASP   A OD2 1 
ATOM   3345 N  N   . LYS   A 1  418 ? -17.793 7.53    -34.474 1    18.908  ? 454  LYS   A N   1 
ATOM   3346 C  CA  . LYS   A 1  418 ? -17.465 6.12    -34.304 1    17.911  ? 454  LYS   A CA  1 
ATOM   3347 C  C   . LYS   A 1  418 ? -16.414 5.607   -35.265 1    19.775  ? 454  LYS   A C   1 
ATOM   3348 O  O   . LYS   A 1  418 ? -15.612 4.747   -34.845 1    19.731  ? 454  LYS   A O   1 
ATOM   3349 C  CB  . LYS   A 1  418 ? -18.726 5.259   -34.416 1    17.207  ? 454  LYS   A CB  1 
ATOM   3350 C  CG  . LYS   A 1  418 ? -19.729 5.754   -33.418 1    16.383  ? 454  LYS   A CG  1 
ATOM   3351 C  CD  . LYS   A 1  418 ? -19.476 5.226   -32.02  1    16.697  ? 454  LYS   A CD  1 
ATOM   3352 C  CE  . LYS   A 1  418 ? -20.508 5.58    -31.036 1    16.223  ? 454  LYS   A CE  1 
ATOM   3353 N  NZ  . LYS   A 1  418 ? -20.074 5.216   -29.657 1    17.037  ? 454  LYS   A NZ  1 
ATOM   3354 N  N   . ILE   A 1  419 ? -16.46  6.035   -36.56  1    18.894  ? 455  ILE   A N   1 
ATOM   3355 C  CA  . ILE   A 1  419 ? -15.479 5.482   -37.506 1    17.702  ? 455  ILE   A CA  1 
ATOM   3356 C  C   . ILE   A 1  419 ? -14.102 6.126   -37.276 1    17.87   ? 455  ILE   A C   1 
ATOM   3357 O  O   . ILE   A 1  419 ? -13.052 5.457   -37.337 1    16.918  ? 455  ILE   A O   1 
ATOM   3358 C  CB  . ILE   A 1  419 ? -15.969 5.691   -38.96  1    15.787  ? 455  ILE   A CB  1 
ATOM   3359 C  CG1 . ILE   A 1  419 ? -17.23  4.891   -39.272 1    19.28   ? 455  ILE   A CG1 1 
ATOM   3360 C  CG2 . ILE   A 1  419 ? -14.832 5.378   -39.962 1    15.02   ? 455  ILE   A CG2 1 
ATOM   3361 C  CD1 . ILE   A 1  419 ? -17.04  3.421   -38.984 1    19.442  ? 455  ILE   A CD1 1 
ATOM   3362 N  N   . ALA   A 1  420 ? -14.097 7.46    -37.071 1    18.438  ? 456  ALA   A N   1 
ATOM   3363 C  CA  . ALA   A 1  420 ? -12.845 8.182   -36.902 1    16.897  ? 456  ALA   A CA  1 
ATOM   3364 C  C   . ALA   A 1  420 ? -12.114 7.667   -35.669 1    16.665  ? 456  ALA   A C   1 
ATOM   3365 O  O   . ALA   A 1  420 ? -10.877 7.689   -35.647 1    18.634  ? 456  ALA   A O   1 
ATOM   3366 C  CB  . ALA   A 1  420 ? -13.049 9.725   -36.799 1    16.928  ? 456  ALA   A CB  1 
ATOM   3367 N  N   . PHE   A 1  421 ? -12.833 7.229   -34.633 1    14.145  ? 457  PHE   A N   1 
ATOM   3368 C  CA  . PHE   A 1  421 ? -12.087 6.848   -33.447 1    13.391  ? 457  PHE   A CA  1 
ATOM   3369 C  C   . PHE   A 1  421 ? -11.483 5.444   -33.633 1    16.259  ? 457  PHE   A C   1 
ATOM   3370 O  O   . PHE   A 1  421 ? -10.594 5.069   -32.876 1    17.463  ? 457  PHE   A O   1 
ATOM   3371 C  CB  . PHE   A 1  421 ? -13.153 6.773   -32.375 1    19.121  ? 457  PHE   A CB  1 
ATOM   3372 C  CG  . PHE   A 1  421 ? -12.616 6.437   -30.989 1    21.959  ? 457  PHE   A CG  1 
ATOM   3373 C  CD1 . PHE   A 1  421 ? -11.971 7.404   -30.211 1    20.68   ? 457  PHE   A CD1 1 
ATOM   3374 C  CD2 . PHE   A 1  421 ? -12.837 5.178   -30.447 1    23.025  ? 457  PHE   A CD2 1 
ATOM   3375 C  CE1 . PHE   A 1  421 ? -11.541 7.13    -28.909 1    19.401  ? 457  PHE   A CE1 1 
ATOM   3376 C  CE2 . PHE   A 1  421 ? -12.465 4.916   -29.129 1    20.794  ? 457  PHE   A CE2 1 
ATOM   3377 C  CZ  . PHE   A 1  421 ? -11.807 5.88    -28.373 1    19.934  ? 457  PHE   A CZ  1 
ATOM   3378 N  N   . ILE   A 1  422 ? -11.836 4.685   -34.673 1    16.269  ? 458  ILE   A N   1 
ATOM   3379 C  CA  . ILE   A 1  422 ? -11.326 3.315   -34.794 1    17.527  ? 458  ILE   A CA  1 
ATOM   3380 C  C   . ILE   A 1  422 ? -9.788  3.326   -34.898 1    20.183  ? 458  ILE   A C   1 
ATOM   3381 O  O   . ILE   A 1  422 ? -9.123  2.585   -34.15  1    21.833  ? 458  ILE   A O   1 
ATOM   3382 C  CB  . ILE   A 1  422 ? -11.961 2.562   -35.977 1    18.69   ? 458  ILE   A CB  1 
ATOM   3383 C  CG1 . ILE   A 1  422 ? -13.441 2.099   -35.725 1    28.614  ? 458  ILE   A CG1 1 
ATOM   3384 C  CG2 . ILE   A 1  422 ? -11.105 1.387   -36.517 1    17.547  ? 458  ILE   A CG2 1 
ATOM   3385 C  CD1 . ILE   A 1  422 ? -13.584 0.972   -34.7   1    26.981  ? 458  ILE   A CD1 1 
ATOM   3386 N  N   . PRO   A 1  423 ? -9.127  4.06    -35.838 1    17.487  ? 459  PRO   A N   1 
ATOM   3387 C  CA  . PRO   A 1  423 ? -7.682  4.027   -35.868 1    15.745  ? 459  PRO   A CA  1 
ATOM   3388 C  C   . PRO   A 1  423 ? -7.079  4.691   -34.617 1    16.343  ? 459  PRO   A C   1 
ATOM   3389 O  O   . PRO   A 1  423 ? -6.054  4.195   -34.194 1    14.833  ? 459  PRO   A O   1 
ATOM   3390 C  CB  . PRO   A 1  423 ? -7.301  4.749   -37.172 1    18.034  ? 459  PRO   A CB  1 
ATOM   3391 C  CG  . PRO   A 1  423 ? -8.514  5.597   -37.543 1    18.464  ? 459  PRO   A CG  1 
ATOM   3392 C  CD  . PRO   A 1  423 ? -9.696  4.878   -36.94  1    18.156  ? 459  PRO   A CD  1 
ATOM   3393 N  N   . PHE   A 1  424 ? -7.629  5.819   -34.096 1    14.47   ? 460  PHE   A N   1 
ATOM   3394 C  CA  . PHE   A 1  424 ? -7.074  6.368   -32.858 1    15.62   ? 460  PHE   A CA  1 
ATOM   3395 C  C   . PHE   A 1  424 ? -7.044  5.314   -31.718 1    18.948  ? 460  PHE   A C   1 
ATOM   3396 O  O   . PHE   A 1  424 ? -5.989  5.08    -31.07  1    19.71   ? 460  PHE   A O   1 
ATOM   3397 C  CB  . PHE   A 1  424 ? -7.841  7.609   -32.416 1    16.774  ? 460  PHE   A CB  1 
ATOM   3398 C  CG  . PHE   A 1  424 ? -7.227  8.177   -31.155 1    17.647  ? 460  PHE   A CG  1 
ATOM   3399 C  CD1 . PHE   A 1  424 ? -6.107  9.026   -31.267 1    17.413  ? 460  PHE   A CD1 1 
ATOM   3400 C  CD2 . PHE   A 1  424 ? -7.797  7.973   -29.887 1    14.451  ? 460  PHE   A CD2 1 
ATOM   3401 C  CE1 . PHE   A 1  424 ? -5.496  9.568   -30.14  1    18.449  ? 460  PHE   A CE1 1 
ATOM   3402 C  CE2 . PHE   A 1  424 ? -7.159  8.513   -28.769 1    14.34   ? 460  PHE   A CE2 1 
ATOM   3403 C  CZ  . PHE   A 1  424 ? -6.016  9.327   -28.875 1    16.931  ? 460  PHE   A CZ  1 
ATOM   3404 N  N   . SER   A 1  425 ? -8.167  4.613   -31.504 1    17.756  ? 461  SER   A N   1 
ATOM   3405 C  CA  . SER   A 1  425 ? -8.282  3.733   -30.346 1    17.664  ? 461  SER   A CA  1 
ATOM   3406 C  C   . SER   A 1  425 ? -7.361  2.541   -30.532 1    17.663  ? 461  SER   A C   1 
ATOM   3407 O  O   . SER   A 1  425 ? -6.991  1.857   -29.556 1    19.108  ? 461  SER   A O   1 
ATOM   3408 C  CB  . SER   A 1  425 ? -9.649  3.251   -30.1   1    17.014  ? 461  SER   A CB  1 
ATOM   3409 O  OG  . SER   A 1  425 ? -10.11  2.519   -31.241 1    18.601  ? 461  SER   A OG  1 
ATOM   3410 N  N   . TYR   A 1  426 ? -7.132  2.212   -31.804 1    18.133  ? 462  TYR   A N   1 
ATOM   3411 C  CA  . TYR   A 1  426 ? -6.229  1.117   -32.143 1    19.005  ? 462  TYR   A CA  1 
ATOM   3412 C  C   . TYR   A 1  426 ? -4.783  1.53    -31.886 1    18.274  ? 462  TYR   A C   1 
ATOM   3413 O  O   . TYR   A 1  426 ? -4      0.758   -31.349 1    22.017  ? 462  TYR   A O   1 
ATOM   3414 C  CB  . TYR   A 1  426 ? -6.315  0.826   -33.656 1    19.352  ? 462  TYR   A CB  1 
ATOM   3415 C  CG  . TYR   A 1  426 ? -5.535  -0.416  -34.083 1    20.687  ? 462  TYR   A CG  1 
ATOM   3416 C  CD1 . TYR   A 1  426 ? -5.897  -1.649  -33.592 1    23.195  ? 462  TYR   A CD1 1 
ATOM   3417 C  CD2 . TYR   A 1  426 ? -4.485  -0.374  -35.001 1    20.349  ? 462  TYR   A CD2 1 
ATOM   3418 C  CE1 . TYR   A 1  426 ? -5.242  -2.805  -34     1    23.269  ? 462  TYR   A CE1 1 
ATOM   3419 C  CE2 . TYR   A 1  426 ? -3.81   -1.525  -35.412 1    23.495  ? 462  TYR   A CE2 1 
ATOM   3420 C  CZ  . TYR   A 1  426 ? -4.221  -2.756  -34.921 1    21.972  ? 462  TYR   A CZ  1 
ATOM   3421 O  OH  . TYR   A 1  426 ? -3.675  -3.98   -35.201 1    24.874  ? 462  TYR   A OH  1 
ATOM   3422 N  N   . LEU   A 1  427 ? -4.391  2.768   -32.221 1    15.62   ? 463  LEU   A N   1 
ATOM   3423 C  CA  . LEU   A 1  427 ? -2.974  3.097   -32.218 1    19.398  ? 463  LEU   A CA  1 
ATOM   3424 C  C   . LEU   A 1  427 ? -2.385  3.35    -30.83  1    17.179  ? 463  LEU   A C   1 
ATOM   3425 O  O   . LEU   A 1  427 ? -1.171  3.113   -30.647 1    17.956  ? 463  LEU   A O   1 
ATOM   3426 C  CB  . LEU   A 1  427 ? -2.621  4.23    -33.17  1    21.421  ? 463  LEU   A CB  1 
ATOM   3427 C  CG  . LEU   A 1  427 ? -2.989  5.639   -32.724 1    24.657  ? 463  LEU   A CG  1 
ATOM   3428 C  CD1 . LEU   A 1  427 ? -1.868  6.391   -32.004 1    20.933  ? 463  LEU   A CD1 1 
ATOM   3429 C  CD2 . LEU   A 1  427 ? -3.265  6.387   -33.985 1    21.94   ? 463  LEU   A CD2 1 
ATOM   3430 N  N   . VAL   A 1  428 ? -3.195  3.84    -29.895 1    15.376  ? 464  VAL   A N   1 
ATOM   3431 C  CA  . VAL   A 1  428 ? -2.662  4.245   -28.6   1    16.993  ? 464  VAL   A CA  1 
ATOM   3432 C  C   . VAL   A 1  428 ? -1.831  3.126   -27.953 1    14.627  ? 464  VAL   A C   1 
ATOM   3433 O  O   . VAL   A 1  428 ? -0.687  3.328   -27.523 1    16.079  ? 464  VAL   A O   1 
ATOM   3434 C  CB  . VAL   A 1  428 ? -3.743  4.796   -27.646 1    16.748  ? 464  VAL   A CB  1 
ATOM   3435 C  CG1 . VAL   A 1  428 ? -3.131  5.094   -26.266 1    17.664  ? 464  VAL   A CG1 1 
ATOM   3436 C  CG2 . VAL   A 1  428 ? -4.474  6.023   -28.239 1    19.277  ? 464  VAL   A CG2 1 
ATOM   3437 N  N   . ASP   A 1  429 ? -2.382  1.941   -27.828 1    15.611  ? 465  ASP   A N   1 
ATOM   3438 C  CA  . ASP   A 1  429 ? -1.607  0.887   -27.198 1    17.7    ? 465  ASP   A CA  1 
ATOM   3439 C  C   . ASP   A 1  429 ? -0.708  0.206   -28.231 1    19.131  ? 465  ASP   A C   1 
ATOM   3440 O  O   . ASP   A 1  429 ? 0.214   -0.486  -27.806 1    17.971  ? 465  ASP   A O   1 
ATOM   3441 C  CB  . ASP   A 1  429 ? -2.502  -0.111  -26.472 1    16.836  ? 465  ASP   A CB  1 
ATOM   3442 C  CG  . ASP   A 1  429 ? -3.005  0.413   -25.12  1    17.768  ? 465  ASP   A CG  1 
ATOM   3443 O  OD1 . ASP   A 1  429 ? -2.503  1.478   -24.73  1    19.083  ? 465  ASP   A OD1 1 
ATOM   3444 O  OD2 . ASP   A 1  429 ? -3.878  -0.227  -24.456 1    16.919  ? 465  ASP   A OD2 1 
ATOM   3445 N  N   . GLN   A 1  430 ? -0.91   0.39    -29.561 1    18.503  ? 466  GLN   A N   1 
ATOM   3446 C  CA  . GLN   A 1  430 ? 0.207   -0.122  -30.384 1    17.069  ? 466  GLN   A CA  1 
ATOM   3447 C  C   . GLN   A 1  430 ? 1.524   0.577   -29.993 1    18.73   ? 466  GLN   A C   1 
ATOM   3448 O  O   . GLN   A 1  430 ? 2.603   -0.042  -29.917 1    20.225  ? 466  GLN   A O   1 
ATOM   3449 C  CB  . GLN   A 1  430 ? -0.039  0.077   -31.885 1    17.914  ? 466  GLN   A CB  1 
ATOM   3450 C  CG  . GLN   A 1  430 ? -1.236  -0.647  -32.486 1    19.006  ? 466  GLN   A CG  1 
ATOM   3451 C  CD  . GLN   A 1  430 ? -1.221  -2.138  -32.291 1    21.708  ? 466  GLN   A CD  1 
ATOM   3452 O  OE1 . GLN   A 1  430 ? -0.186  -2.789  -32.206 1    19.709  ? 466  GLN   A OE1 1 
ATOM   3453 N  NE2 . GLN   A 1  430 ? -2.392  -2.717  -32.107 1    24.282  ? 466  GLN   A NE2 1 
ATOM   3454 N  N   . TRP   A 1  431 ? 1.452   1.899   -29.773 1    18.141  ? 467  TRP   A N   1 
ATOM   3455 C  CA  . TRP   A 1  431 ? 2.576   2.686   -29.298 1    20.543  ? 467  TRP   A CA  1 
ATOM   3456 C  C   . TRP   A 1  431 ? 2.984   2.245   -27.887 1    19.15   ? 467  TRP   A C   1 
ATOM   3457 O  O   . TRP   A 1  431 ? 4.152   1.918   -27.683 1    18.141  ? 467  TRP   A O   1 
ATOM   3458 C  CB  . TRP   A 1  431 ? 2.225   4.186   -29.35  1    18.402  ? 467  TRP   A CB  1 
ATOM   3459 C  CG  . TRP   A 1  431 ? 3.343   5.081   -28.863 1    18.111  ? 467  TRP   A CG  1 
ATOM   3460 C  CD1 . TRP   A 1  431 ? 4.379   5.576   -29.633 1    16.825  ? 467  TRP   A CD1 1 
ATOM   3461 C  CD2 . TRP   A 1  431 ? 3.544   5.57    -27.517 1    17.445  ? 467  TRP   A CD2 1 
ATOM   3462 N  NE1 . TRP   A 1  431 ? 5.215   6.343   -28.862 1    16.671  ? 467  TRP   A NE1 1 
ATOM   3463 C  CE2 . TRP   A 1  431 ? 4.71    6.387   -27.561 1    18.761  ? 467  TRP   A CE2 1 
ATOM   3464 C  CE3 . TRP   A 1  431 ? 2.811   5.501   -26.326 1    15.611  ? 467  TRP   A CE3 1 
ATOM   3465 C  CZ2 . TRP   A 1  431 ? 5.18    7.031   -26.413 1    17.127  ? 467  TRP   A CZ2 1 
ATOM   3466 C  CZ3 . TRP   A 1  431 ? 3.265   6.158   -25.197 1    15.44   ? 467  TRP   A CZ3 1 
ATOM   3467 C  CH2 . TRP   A 1  431 ? 4.456   6.92    -25.242 1    18.342  ? 467  TRP   A CH2 1 
ATOM   3468 N  N   . ARG   A 1  432 ? 2.055   2.173   -26.918 1    19.245  ? 468  ARG   A N   1 
ATOM   3469 C  CA  . ARG   A 1  432 ? 2.497   1.843   -25.554 1    19.423  ? 468  ARG   A CA  1 
ATOM   3470 C  C   . ARG   A 1  432 ? 3.024   0.412   -25.466 1    18.152  ? 468  ARG   A C   1 
ATOM   3471 O  O   . ARG   A 1  432 ? 3.916   0.179   -24.686 1    18.333  ? 468  ARG   A O   1 
ATOM   3472 C  CB  . ARG   A 1  432 ? 1.406   1.919   -24.481 1    19.332  ? 468  ARG   A CB  1 
ATOM   3473 C  CG  . ARG   A 1  432 ? 1.268   3.285   -23.848 1    21.25   ? 468  ARG   A CG  1 
ATOM   3474 C  CD  . ARG   A 1  432 ? 0.587   3.28    -22.445 1    17.657  ? 468  ARG   A CD  1 
ATOM   3475 N  NE  . ARG   A 1  432 ? -0.831  3.15    -22.856 1    16.235  ? 468  ARG   A NE  1 
ATOM   3476 C  CZ  . ARG   A 1  432 ? -1.83   3.594   -22.152 1    15.879  ? 468  ARG   A CZ  1 
ATOM   3477 N  NH1 . ARG   A 1  432 ? -1.59   4.323   -21.057 1    14.262  ? 468  ARG   A NH1 1 
ATOM   3478 N  NH2 . ARG   A 1  432 ? -3.058  3.338   -22.593 1    15.901  ? 468  ARG   A NH2 1 
ATOM   3479 N  N   . TRP   A 1  433 ? 2.465   -0.546  -26.23  1    17.904  ? 469  TRP   A N   1 
ATOM   3480 C  CA  . TRP   A 1  433 ? 2.975   -1.91   -26.174 1    19.566  ? 469  TRP   A CA  1 
ATOM   3481 C  C   . TRP   A 1  433 ? 4.439   -1.947  -26.595 1    21.869  ? 469  TRP   A C   1 
ATOM   3482 O  O   . TRP   A 1  433 ? 5.184   -2.646  -25.968 1    19.106  ? 469  TRP   A O   1 
ATOM   3483 C  CB  . TRP   A 1  433 ? 2.214   -2.908  -27.042 1    18.107  ? 469  TRP   A CB  1 
ATOM   3484 C  CG  . TRP   A 1  433 ? 0.812   -3.189  -26.532 1    21.651  ? 469  TRP   A CG  1 
ATOM   3485 C  CD1 . TRP   A 1  433 ? 0.285   -2.97   -25.291 1    19.15   ? 469  TRP   A CD1 1 
ATOM   3486 C  CD2 . TRP   A 1  433 ? -0.272  -3.711  -27.333 1    20.328  ? 469  TRP   A CD2 1 
ATOM   3487 N  NE1 . TRP   A 1  433 ? -1.04   -3.327  -25.27  1    18.709  ? 469  TRP   A NE1 1 
ATOM   3488 C  CE2 . TRP   A 1  433 ? -1.412  -3.76   -26.518 1    19.09   ? 469  TRP   A CE2 1 
ATOM   3489 C  CE3 . TRP   A 1  433 ? -0.364  -4.075  -28.68  1    22.38   ? 469  TRP   A CE3 1 
ATOM   3490 C  CZ2 . TRP   A 1  433 ? -2.639  -4.249  -26.981 1    24.189  ? 469  TRP   A CZ2 1 
ATOM   3491 C  CZ3 . TRP   A 1  433 ? -1.584  -4.494  -29.154 1    21.309  ? 469  TRP   A CZ3 1 
ATOM   3492 C  CH2 . TRP   A 1  433 ? -2.717  -4.595  -28.32  1    22.39   ? 469  TRP   A CH2 1 
ATOM   3493 N  N   . ARG   A 1  434 ? 4.823   -1.137  -27.591 1    17.953  ? 470  ARG   A N   1 
ATOM   3494 C  CA  . ARG   A 1  434 ? 6.215   -1.036  -28.061 1    18.759  ? 470  ARG   A CA  1 
ATOM   3495 C  C   . ARG   A 1  434 ? 7.115   -0.222  -27.106 1    21.286  ? 470  ARG   A C   1 
ATOM   3496 O  O   . ARG   A 1  434 ? 8.328   -0.546  -26.983 1    19.951  ? 470  ARG   A O   1 
ATOM   3497 C  CB  . ARG   A 1  434 ? 6.206   -0.458  -29.497 1    16.453  ? 470  ARG   A CB  1 
ATOM   3498 C  CG  . ARG   A 1  434 ? 5.725   -1.538  -30.464 1    19.54   ? 470  ARG   A CG  1 
ATOM   3499 C  CD  . ARG   A 1  434 ? 5.489   -0.945  -31.92  1    25.899  ? 470  ARG   A CD  1 
ATOM   3500 N  NE  . ARG   A 1  434 ? 6.74    -0.514  -32.565 1    37.186  ? 470  ARG   A NE  1 
ATOM   3501 C  CZ  . ARG   A 1  434 ? 7.049   0.68    -33.12  1    37.906  ? 470  ARG   A CZ  1 
ATOM   3502 N  NH1 . ARG   A 1  434 ? 6.124   1.543   -33.507 1    36.409  ? 470  ARG   A NH1 1 
ATOM   3503 N  NH2 . ARG   A 1  434 ? 8.324   0.985   -33.31  1    38.764  ? 470  ARG   A NH2 1 
ATOM   3504 N  N   . VAL   A 1  435 ? 6.567   0.801   -26.415 1    18.556  ? 471  VAL   A N   1 
ATOM   3505 C  CA  . VAL   A 1  435 ? 7.274   1.399   -25.284 1    17.695  ? 471  VAL   A CA  1 
ATOM   3506 C  C   . VAL   A 1  435 ? 7.554   0.346   -24.201 1    19.622  ? 471  VAL   A C   1 
ATOM   3507 O  O   . VAL   A 1  435 ? 8.72    0.212   -23.705 1    17.606  ? 471  VAL   A O   1 
ATOM   3508 C  CB  . VAL   A 1  435 ? 6.55    2.613   -24.722 1    18.184  ? 471  VAL   A CB  1 
ATOM   3509 C  CG1 . VAL   A 1  435 ? 7.188   3.041   -23.387 1    16.161  ? 471  VAL   A CG1 1 
ATOM   3510 C  CG2 . VAL   A 1  435 ? 6.567   3.727   -25.773 1    16.926  ? 471  VAL   A CG2 1 
ATOM   3511 N  N   . PHE   A 1  436 ? 6.518   -0.441  -23.85  1    16.978  ? 472  PHE   A N   1 
ATOM   3512 C  CA  . PHE   A 1  436 ? 6.711   -1.395  -22.757 1    20.808  ? 472  PHE   A CA  1 
ATOM   3513 C  C   . PHE   A 1  436 ? 7.725   -2.472  -23.121 1    22.038  ? 472  PHE   A C   1 
ATOM   3514 O  O   . PHE   A 1  436 ? 8.464   -2.96   -22.237 1    19.432  ? 472  PHE   A O   1 
ATOM   3515 C  CB  . PHE   A 1  436 ? 5.371   -2.016  -22.302 1    17.429  ? 472  PHE   A CB  1 
ATOM   3516 C  CG  . PHE   A 1  436 ? 4.513   -1.014  -21.544 1    18.611  ? 472  PHE   A CG  1 
ATOM   3517 C  CD1 . PHE   A 1  436 ? 5.08    -0.017  -20.739 1    20.276  ? 472  PHE   A CD1 1 
ATOM   3518 C  CD2 . PHE   A 1  436 ? 3.119   -1.084  -21.632 1    19.412  ? 472  PHE   A CD2 1 
ATOM   3519 C  CE1 . PHE   A 1  436 ? 4.261   0.911   -20.077 1    18.674  ? 472  PHE   A CE1 1 
ATOM   3520 C  CE2 . PHE   A 1  436 ? 2.279   -0.189  -20.947 1    18.159  ? 472  PHE   A CE2 1 
ATOM   3521 C  CZ  . PHE   A 1  436 ? 2.872   0.821   -20.186 1    17.748  ? 472  PHE   A CZ  1 
ATOM   3522 N  N   . ASP   A 1  437 ? 7.651   -2.928  -24.4   1    19.922  ? 473  ASP   A N   1 
ATOM   3523 C  CA  . ASP   A 1  437 ? 8.499   -4.045  -24.783 1    19.607  ? 473  ASP   A CA  1 
ATOM   3524 C  C   . ASP   A 1  437 ? 9.892   -3.518  -25.137 1    22.662  ? 473  ASP   A C   1 
ATOM   3525 O  O   . ASP   A 1  437 ? 10.727  -4.275  -25.574 1    25.355  ? 473  ASP   A O   1 
ATOM   3526 C  CB  . ASP   A 1  437 ? 7.891   -4.948  -25.844 1    19.556  ? 473  ASP   A CB  1 
ATOM   3527 C  CG  . ASP   A 1  437 ? 7.972   -4.431  -27.27  1    21.247  ? 473  ASP   A CG  1 
ATOM   3528 O  OD1 . ASP   A 1  437 ? 8.579   -3.354  -27.509 1    21.402  ? 473  ASP   A OD1 1 
ATOM   3529 O  OD2 . ASP   A 1  437 ? 7.399   -5.085  -28.103 1    24.026  ? 473  ASP   A OD2 1 
ATOM   3530 N  N   . GLY   A 1  438 ? 10.177  -2.222  -25.005 1    19.427  ? 474  GLY   A N   1 
ATOM   3531 C  CA  . GLY   A 1  438 ? 11.538  -1.772  -25.25  1    21.528  ? 474  GLY   A CA  1 
ATOM   3532 C  C   . GLY   A 1  438 ? 11.849  -1.423  -26.719 1    28.331  ? 474  GLY   A C   1 
ATOM   3533 O  O   . GLY   A 1  438 ? 12.907  -0.865  -26.997 1    26.95   ? 474  GLY   A O   1 
ATOM   3534 N  N   A SER   A 1  439 ? 10.907  -1.727  -27.621 0.43 24.244  ? 475  SER   A N   1 
ATOM   3535 N  N   B SER   A 1  439 ? 10.955  -1.674  -27.685 0.57 24.956  ? 475  SER   A N   1 
ATOM   3536 C  CA  A SER   A 1  439 ? 11.03   -1.361  -29.022 0.43 24.006  ? 475  SER   A CA  1 
ATOM   3537 C  CA  B SER   A 1  439 ? 11.316  -1.289  -29.047 0.57 25.137  ? 475  SER   A CA  1 
ATOM   3538 C  C   A SER   A 1  439 ? 11.219  0.153   -29.202 0.43 23.135  ? 475  SER   A C   1 
ATOM   3539 C  C   B SER   A 1  439 ? 11.089  0.209   -29.359 0.57 24.845  ? 475  SER   A C   1 
ATOM   3540 O  O   A SER   A 1  439 ? 12.025  0.563   -30.033 0.43 20.607  ? 475  SER   A O   1 
ATOM   3541 O  O   B SER   A 1  439 ? 11.451  0.687   -30.434 0.57 21.876  ? 475  SER   A O   1 
ATOM   3542 C  CB  A SER   A 1  439 ? 9.852   -1.87   -29.832 0.43 25.808  ? 475  SER   A CB  1 
ATOM   3543 C  CB  B SER   A 1  439 ? 10.693  -2.198  -30.082 0.57 27.53   ? 475  SER   A CB  1 
ATOM   3544 O  OG  A SER   A 1  439 ? 9.825   -3.294  -29.867 0.43 25.087  ? 475  SER   A OG  1 
ATOM   3545 O  OG  B SER   A 1  439 ? 9.273   -2.168  -29.987 0.57 26.647  ? 475  SER   A OG  1 
ATOM   3546 N  N   . ILE   A 1  440 ? 10.459  0.979   -28.461 1    20.958  ? 476  ILE   A N   1 
ATOM   3547 C  CA  . ILE   A 1  440 ? 10.495  2.436   -28.56  1    20.487  ? 476  ILE   A CA  1 
ATOM   3548 C  C   . ILE   A 1  440 ? 11.169  2.914   -27.273 1    23.58   ? 476  ILE   A C   1 
ATOM   3549 O  O   . ILE   A 1  440 ? 10.779  2.399   -26.236 1    23.439  ? 476  ILE   A O   1 
ATOM   3550 C  CB  . ILE   A 1  440 ? 9.032   2.979   -28.677 1    22.92   ? 476  ILE   A CB  1 
ATOM   3551 C  CG1 . ILE   A 1  440 ? 8.293   2.559   -29.992 1    20.483  ? 476  ILE   A CG1 1 
ATOM   3552 C  CG2 . ILE   A 1  440 ? 9.075   4.497   -28.543 1    17.842  ? 476  ILE   A CG2 1 
ATOM   3553 C  CD1 . ILE   A 1  440 ? 6.793   2.89    -30.061 1    17.994  ? 476  ILE   A CD1 1 
ATOM   3554 N  N   . THR   A 1  441 ? 12.181  3.822   -27.288 1    23.349  ? 477  THR   A N   1 
ATOM   3555 C  CA  . THR   A 1  441 ? 12.818  4.272   -26.054 1    21.601  ? 477  THR   A CA  1 
ATOM   3556 C  C   . THR   A 1  441 ? 12.471  5.734   -25.906 1    21.065  ? 477  THR   A C   1 
ATOM   3557 O  O   . THR   A 1  441 ? 11.907  6.267   -26.868 1    21.611  ? 477  THR   A O   1 
ATOM   3558 C  CB  . THR   A 1  441 ? 14.357  4.148   -26.129 1    23.487  ? 477  THR   A CB  1 
ATOM   3559 O  OG1 . THR   A 1  441 ? 14.808  5.101   -27.096 1    22.348  ? 477  THR   A OG1 1 
ATOM   3560 C  CG2 . THR   A 1  441 ? 14.747  2.78    -26.63  1    17.456  ? 477  THR   A CG2 1 
ATOM   3561 N  N   . LYS   A 1  442 ? 12.99   6.365   -24.825 1    19.609  ? 478  LYS   A N   1 
ATOM   3562 C  CA  . LYS   A 1  442 ? 12.773  7.784   -24.617 1    21.87   ? 478  LYS   A CA  1 
ATOM   3563 C  C   . LYS   A 1  442 ? 13.452  8.544   -25.732 1    23.809  ? 478  LYS   A C   1 
ATOM   3564 O  O   . LYS   A 1  442 ? 13.089  9.684   -25.934 1    23.091  ? 478  LYS   A O   1 
ATOM   3565 C  CB  . LYS   A 1  442 ? 13.192  8.448   -23.282 1    24.918  ? 478  LYS   A CB  1 
ATOM   3566 C  CG  . LYS   A 1  442 ? 14.693  8.496   -22.992 1    27.077  ? 478  LYS   A CG  1 
ATOM   3567 C  CD  . LYS   A 1  442 ? 14.948  9.174   -21.642 1    25.627  ? 478  LYS   A CD  1 
ATOM   3568 C  CE  . LYS   A 1  442 ? 16.426  9.286   -21.452 1    27.929  ? 478  LYS   A CE  1 
ATOM   3569 N  NZ  . LYS   A 1  442 ? 16.665  9.836   -20.13  1    29.98   ? 478  LYS   A NZ  1 
ATOM   3570 N  N   . GLU   A 1  443 ? 14.423  7.935   -26.441 1    24.8    ? 479  GLU   A N   1 
ATOM   3571 C  CA  . GLU   A 1  443 ? 14.997  8.679   -27.562 1    21.834  ? 479  GLU   A CA  1 
ATOM   3572 C  C   . GLU   A 1  443 ? 13.97   8.904   -28.694 1    26.765  ? 479  GLU   A C   1 
ATOM   3573 O  O   . GLU   A 1  443 ? 14.133  9.839   -29.455 1    26.01   ? 479  GLU   A O   1 
ATOM   3574 C  CB  . GLU   A 1  443 ? 16.154  7.918   -28.161 1    24.381  ? 479  GLU   A CB  1 
ATOM   3575 C  CG  . GLU   A 1  443 ? 17.192  7.467   -27.123 1    26.035  ? 479  GLU   A CG  1 
ATOM   3576 C  CD  . GLU   A 1  443 ? 18.04   6.384   -27.776 1    28.516  ? 479  GLU   A CD  1 
ATOM   3577 O  OE1 . GLU   A 1  443 ? 17.42   5.346   -28.182 1    25.93   ? 479  GLU   A OE1 1 
ATOM   3578 O  OE2 . GLU   A 1  443 ? 19.288  6.595   -27.966 1    30.533  ? 479  GLU   A OE2 1 
ATOM   3579 N  N   . ASN   A 1  444 ? 12.994  8.017   -28.899 1    21.853  ? 480  ASN   A N   1 
ATOM   3580 C  CA  . ASN   A 1  444 ? 12.057  8.16    -30.017 1    25.964  ? 480  ASN   A CA  1 
ATOM   3581 C  C   . ASN   A 1  444 ? 10.566  7.94    -29.682 1    23.852  ? 480  ASN   A C   1 
ATOM   3582 O  O   . ASN   A 1  444 ? 9.775   7.651   -30.581 1    21.561  ? 480  ASN   A O   1 
ATOM   3583 C  CB  . ASN   A 1  444 ? 12.443  7.321   -31.224 1    25.771  ? 480  ASN   A CB  1 
ATOM   3584 C  CG  . ASN   A 1  444 ? 12.459  5.879   -30.85  1    27.836  ? 480  ASN   A CG  1 
ATOM   3585 O  OD1 . ASN   A 1  444 ? 12.325  5.544   -29.664 1    32.27   ? 480  ASN   A OD1 1 
ATOM   3586 N  ND2 . ASN   A 1  444 ? 12.599  5.022   -31.837 1    32.711  ? 480  ASN   A ND2 1 
ATOM   3587 N  N   . TYR   A 1  445 ? 10.205  8.147   -28.411 1    22.037  ? 481  TYR   A N   1 
ATOM   3588 C  CA  . TYR   A 1  445 ? 8.821   8.2     -27.985 1    19.228  ? 481  TYR   A CA  1 
ATOM   3589 C  C   . TYR   A 1  445 ? 8.011   8.984   -29.019 1    19.947  ? 481  TYR   A C   1 
ATOM   3590 O  O   . TYR   A 1  445 ? 7.022   8.438   -29.525 1    18.088  ? 481  TYR   A O   1 
ATOM   3591 C  CB  . TYR   A 1  445 ? 8.706   8.997   -26.699 1    19.569  ? 481  TYR   A CB  1 
ATOM   3592 C  CG  . TYR   A 1  445 ? 9.011   8.312   -25.371 1    19.669  ? 481  TYR   A CG  1 
ATOM   3593 C  CD1 . TYR   A 1  445 ? 9.063   6.921   -25.232 1    19.989  ? 481  TYR   A CD1 1 
ATOM   3594 C  CD2 . TYR   A 1  445 ? 9.348   9.099   -24.276 1    17.741  ? 481  TYR   A CD2 1 
ATOM   3595 C  CE1 . TYR   A 1  445 ? 9.41    6.335   -24.004 1    23.108  ? 481  TYR   A CE1 1 
ATOM   3596 C  CE2 . TYR   A 1  445 ? 9.619   8.526   -23.055 1    20.801  ? 481  TYR   A CE2 1 
ATOM   3597 C  CZ  . TYR   A 1  445 ? 9.663   7.152   -22.923 1    20.699  ? 481  TYR   A CZ  1 
ATOM   3598 O  OH  . TYR   A 1  445 ? 10.001  6.663   -21.708 1    19.038  ? 481  TYR   A OH  1 
ATOM   3599 N  N   . ASN   A 1  446 ? 8.384   10.271  -29.248 1    19.156  ? 482  ASN   A N   1 
ATOM   3600 C  CA  . ASN   A 1  446 ? 7.45    11.185  -29.904 1    19.799  ? 482  ASN   A CA  1 
ATOM   3601 C  C   . ASN   A 1  446 ? 7.428   10.867  -31.398 1    19.06   ? 482  ASN   A C   1 
ATOM   3602 O  O   . ASN   A 1  446 ? 6.354   10.864  -32.034 1    20.64   ? 482  ASN   A O   1 
ATOM   3603 C  CB  . ASN   A 1  446 ? 7.922   12.632  -29.817 1    22.183  ? 482  ASN   A CB  1 
ATOM   3604 C  CG  . ASN   A 1  446 ? 6.714   13.533  -29.779 1    23.06   ? 482  ASN   A CG  1 
ATOM   3605 O  OD1 . ASN   A 1  446 ? 5.84    13.289  -28.958 1    24.726  ? 482  ASN   A OD1 1 
ATOM   3606 N  ND2 . ASN   A 1  446 ? 6.629   14.546  -30.629 1    20.315  ? 482  ASN   A ND2 1 
ATOM   3607 N  N   . GLN   A 1  447 ? 8.6     10.5    -31.951 1    17.976  ? 483  GLN   A N   1 
ATOM   3608 C  CA  . GLN   A 1  447 ? 8.698   10.196  -33.38  1    21.877  ? 483  GLN   A CA  1 
ATOM   3609 C  C   . GLN   A 1  447 ? 7.898   8.915   -33.683 1    21.149  ? 483  GLN   A C   1 
ATOM   3610 O  O   . GLN   A 1  447 ? 7.192   8.838   -34.697 1    20.891  ? 483  GLN   A O   1 
ATOM   3611 C  CB  . GLN   A 1  447 ? 10.171  10.052  -33.789 1    21.991  ? 483  GLN   A CB  1 
ATOM   3612 C  CG  . GLN   A 1  447 ? 10.995  11.351  -33.658 1    27.21   ? 483  GLN   A CG  1 
ATOM   3613 C  CD  . GLN   A 1  447 ? 11.744  11.543  -32.322 1    42.38   ? 483  GLN   A CD  1 
ATOM   3614 O  OE1 . GLN   A 1  447 ? 11.317  11.121  -31.203 1    26.569  ? 483  GLN   A OE1 1 
ATOM   3615 N  NE2 . GLN   A 1  447 ? 12.915  12.199  -32.422 1    32.051  ? 483  GLN   A NE2 1 
ATOM   3616 N  N   . GLU   A 1  448 ? 7.904   7.964   -32.75  1    18.571  ? 484  GLU   A N   1 
ATOM   3617 C  CA  . GLU   A 1  448 ? 7.159   6.738   -33.063 1    21.774  ? 484  GLU   A CA  1 
ATOM   3618 C  C   . GLU   A 1  448 ? 5.663   7.002   -32.887 1    20.761  ? 484  GLU   A C   1 
ATOM   3619 O  O   . GLU   A 1  448 ? 4.851   6.405   -33.58  1    22.119  ? 484  GLU   A O   1 
ATOM   3620 C  CB  . GLU   A 1  448 ? 7.68    5.553   -32.234 1    21.418  ? 484  GLU   A CB  1 
ATOM   3621 C  CG  . GLU   A 1  448 ? 9.109   5.128   -32.655 1    25.202  ? 484  GLU   A CG  1 
ATOM   3622 C  CD  . GLU   A 1  448 ? 8.906   4.449   -34.02  1    34.892  ? 484  GLU   A CD  1 
ATOM   3623 O  OE1 . GLU   A 1  448 ? 8.137   3.467   -34.208 1    45.833  ? 484  GLU   A OE1 1 
ATOM   3624 O  OE2 . GLU   A 1  448 ? 9.397   5.055   -34.943 1    38.246  ? 484  GLU   A OE2 1 
ATOM   3625 N  N   . TRP   A 1  449 ? 5.324   7.901   -31.964 1    19.326  ? 485  TRP   A N   1 
ATOM   3626 C  CA  . TRP   A 1  449 ? 3.921   8.245   -31.798 1    22.642  ? 485  TRP   A CA  1 
ATOM   3627 C  C   . TRP   A 1  449 ? 3.435   8.848   -33.135 1    22.693  ? 485  TRP   A C   1 
ATOM   3628 O  O   . TRP   A 1  449 ? 2.414   8.419   -33.643 1    18.353  ? 485  TRP   A O   1 
ATOM   3629 C  CB  . TRP   A 1  449 ? 3.768   9.248   -30.647 1    20.36   ? 485  TRP   A CB  1 
ATOM   3630 C  CG  . TRP   A 1  449 ? 2.422   9.892   -30.557 1    15.098  ? 485  TRP   A CG  1 
ATOM   3631 C  CD1 . TRP   A 1  449 ? 2.066   11.177  -30.918 1    20.439  ? 485  TRP   A CD1 1 
ATOM   3632 C  CD2 . TRP   A 1  449 ? 1.247   9.318   -29.951 1    19.161  ? 485  TRP   A CD2 1 
ATOM   3633 N  NE1 . TRP   A 1  449 ? 0.752   11.423  -30.607 1    15.315  ? 485  TRP   A NE1 1 
ATOM   3634 C  CE2 . TRP   A 1  449 ? 0.241   10.303  -29.992 1    17.601  ? 485  TRP   A CE2 1 
ATOM   3635 C  CE3 . TRP   A 1  449 ? 0.964   8.07    -29.386 1    18.805  ? 485  TRP   A CE3 1 
ATOM   3636 C  CZ2 . TRP   A 1  449 ? -1.029  10.072  -29.472 1    22.94   ? 485  TRP   A CZ2 1 
ATOM   3637 C  CZ3 . TRP   A 1  449 ? -0.281  7.836   -28.857 1    21.865  ? 485  TRP   A CZ3 1 
ATOM   3638 C  CH2 . TRP   A 1  449 ? -1.258  8.847   -28.868 1    21.89   ? 485  TRP   A CH2 1 
ATOM   3639 N  N   . TRP   A 1  450 ? 4.156   9.813   -33.72  1    17.85   ? 486  TRP   A N   1 
ATOM   3640 C  CA  . TRP   A 1  450 ? 3.71    10.399  -34.974 1    18.034  ? 486  TRP   A CA  1 
ATOM   3641 C  C   . TRP   A 1  450 ? 3.775   9.421   -36.157 1    18.199  ? 486  TRP   A C   1 
ATOM   3642 O  O   . TRP   A 1  450 ? 2.965   9.514   -37.063 1    17.878  ? 486  TRP   A O   1 
ATOM   3643 C  CB  . TRP   A 1  450 ? 4.365   11.766  -35.231 1    16.972  ? 486  TRP   A CB  1 
ATOM   3644 C  CG  . TRP   A 1  450 ? 3.764   12.76   -34.266 1    16.535  ? 486  TRP   A CG  1 
ATOM   3645 C  CD1 . TRP   A 1  450 ? 4.241   13.215  -33.062 1    16.717  ? 486  TRP   A CD1 1 
ATOM   3646 C  CD2 . TRP   A 1  450 ? 2.424   13.296  -34.415 1    18.502  ? 486  TRP   A CD2 1 
ATOM   3647 N  NE1 . TRP   A 1  450 ? 3.305   14.039  -32.464 1    18.595  ? 486  TRP   A NE1 1 
ATOM   3648 C  CE2 . TRP   A 1  450 ? 2.183   14.107  -33.272 1    17.797  ? 486  TRP   A CE2 1 
ATOM   3649 C  CE3 . TRP   A 1  450 ? 1.427   13.181  -35.419 1    18.722  ? 486  TRP   A CE3 1 
ATOM   3650 C  CZ2 . TRP   A 1  450 ? 0.991   14.797  -33.101 1    19.119  ? 486  TRP   A CZ2 1 
ATOM   3651 C  CZ3 . TRP   A 1  450 ? 0.26    13.94   -35.268 1    20.026  ? 486  TRP   A CZ3 1 
ATOM   3652 C  CH2 . TRP   A 1  450 ? 0.028   14.693  -34.111 1    18.273  ? 486  TRP   A CH2 1 
ATOM   3653 N  N   A SER   A 1  451 ? 4.688   8.441   -36.153 0.53 17.93   ? 487  SER   A N   1 
ATOM   3654 N  N   B SER   A 1  451 ? 4.722   8.476   -36.124 0.47 17.454  ? 487  SER   A N   1 
ATOM   3655 C  CA  A SER   A 1  451 ? 4.621   7.438   -37.211 0.53 17.479  ? 487  SER   A CA  1 
ATOM   3656 C  CA  B SER   A 1  451 ? 4.715   7.392   -37.094 0.47 17.055  ? 487  SER   A CA  1 
ATOM   3657 C  C   A SER   A 1  451 ? 3.322   6.64    -37.146 0.53 17.784  ? 487  SER   A C   1 
ATOM   3658 C  C   B SER   A 1  451 ? 3.372   6.666   -37.115 0.47 17.484  ? 487  SER   A C   1 
ATOM   3659 O  O   A SER   A 1  451 ? 2.817   6.235   -38.202 0.53 17.6    ? 487  SER   A O   1 
ATOM   3660 O  O   B SER   A 1  451 ? 2.885   6.339   -38.2   0.47 17.805  ? 487  SER   A O   1 
ATOM   3661 C  CB  A SER   A 1  451 ? 5.824   6.525   -37.225 0.53 18.595  ? 487  SER   A CB  1 
ATOM   3662 C  CB  B SER   A 1  451 ? 5.853   6.426   -36.862 0.47 17.35   ? 487  SER   A CB  1 
ATOM   3663 O  OG  A SER   A 1  451 ? 7.016   7.284   -37.27  0.53 22.578  ? 487  SER   A OG  1 
ATOM   3664 O  OG  B SER   A 1  451 ? 5.715   5.317   -37.742 0.47 18.415  ? 487  SER   A OG  1 
ATOM   3665 N  N   . LEU   A 1  452 ? 2.797   6.376   -35.929 1    16.595  ? 488  LEU   A N   1 
ATOM   3666 C  CA  . LEU   A 1  452 ? 1.558   5.614   -35.845 1    21.107  ? 488  LEU   A CA  1 
ATOM   3667 C  C   . LEU   A 1  452 ? 0.341   6.5     -36.124 1    17.122  ? 488  LEU   A C   1 
ATOM   3668 O  O   . LEU   A 1  452 ? -0.587  6.046   -36.776 1    16.793  ? 488  LEU   A O   1 
ATOM   3669 C  CB  . LEU   A 1  452 ? 1.445   4.809   -34.562 1    19.582  ? 488  LEU   A CB  1 
ATOM   3670 C  CG  . LEU   A 1  452 ? 2.643   3.895   -34.338 1    24.077  ? 488  LEU   A CG  1 
ATOM   3671 C  CD1 . LEU   A 1  452 ? 2.699   3.388   -32.914 1    22.123  ? 488  LEU   A CD1 1 
ATOM   3672 C  CD2 . LEU   A 1  452 ? 2.669   2.728   -35.293 1    25.468  ? 488  LEU   A CD2 1 
ATOM   3673 N  N   . ARG   A 1  453 ? 0.416   7.761   -35.693 1    16.593  ? 489  ARG   A N   1 
ATOM   3674 C  CA  . ARG   A 1  453 ? -0.573  8.779   -36.048 1    16.822  ? 489  ARG   A CA  1 
ATOM   3675 C  C   . ARG   A 1  453 ? -0.743  8.86    -37.57  1    18.752  ? 489  ARG   A C   1 
ATOM   3676 O  O   . ARG   A 1  453 ? -1.86   8.928   -38.103 1    17.902  ? 489  ARG   A O   1 
ATOM   3677 C  CB  . ARG   A 1  453 ? -0.165  10.119  -35.409 1    15.841  ? 489  ARG   A CB  1 
ATOM   3678 C  CG  . ARG   A 1  453 ? -0.383  10.025  -33.882 1    15.425  ? 489  ARG   A CG  1 
ATOM   3679 C  CD  . ARG   A 1  453 ? -1.776  10.322  -33.31  1    16.539  ? 489  ARG   A CD  1 
ATOM   3680 N  NE  . ARG   A 1  453 ? -1.991  11.785  -33.238 1    17.941  ? 489  ARG   A NE  1 
ATOM   3681 C  CZ  . ARG   A 1  453 ? -3.149  12.423  -33.006 1    17.8    ? 489  ARG   A CZ  1 
ATOM   3682 N  NH1 . ARG   A 1  453 ? -3.154  13.708  -32.573 1    15.706  ? 489  ARG   A NH1 1 
ATOM   3683 N  NH2 . ARG   A 1  453 ? -4.286  11.753  -33.085 1    13.522  ? 489  ARG   A NH2 1 
ATOM   3684 N  N   . LEU   A 1  454 ? 0.381   8.859   -38.28  1    18.275  ? 490  LEU   A N   1 
ATOM   3685 C  CA  . LEU   A 1  454 ? 0.357   8.841   -39.735 1    17.854  ? 490  LEU   A CA  1 
ATOM   3686 C  C   . LEU   A 1  454 ? -0.18   7.515   -40.278 1    19.196  ? 490  LEU   A C   1 
ATOM   3687 O  O   . LEU   A 1  454 ? -1.16   7.455   -41.049 1    22.095  ? 490  LEU   A O   1 
ATOM   3688 C  CB  . LEU   A 1  454 ? 1.787   9.124   -40.214 1    20.564  ? 490  LEU   A CB  1 
ATOM   3689 C  CG  . LEU   A 1  454 ? 1.944   9.042   -41.751 1    25.604  ? 490  LEU   A CG  1 
ATOM   3690 C  CD1 . LEU   A 1  454 ? 0.97    9.969   -42.423 1    19.752  ? 490  LEU   A CD1 1 
ATOM   3691 C  CD2 . LEU   A 1  454 ? 3.389   9.225   -42.279 1    24.908  ? 490  LEU   A CD2 1 
ATOM   3692 N  N   . LYS   A 1  455 ? 0.366   6.402   -39.801 1    18.884  ? 491  LYS   A N   1 
ATOM   3693 C  CA  . LYS   A 1  455 ? 0.183   5.132   -40.453 1    21.37   ? 491  LYS   A CA  1 
ATOM   3694 C  C   . LYS   A 1  455 ? -1.272  4.738   -40.269 1    21.083  ? 491  LYS   A C   1 
ATOM   3695 O  O   . LYS   A 1  455 ? -1.889  4.285   -41.228 1    19.598  ? 491  LYS   A O   1 
ATOM   3696 C  CB  . LYS   A 1  455 ? 1.051   4.077   -39.745 1    24.109  ? 491  LYS   A CB  1 
ATOM   3697 C  CG  . LYS   A 1  455 ? 0.787   2.674   -40.363 1    29.46   ? 491  LYS   A CG  1 
ATOM   3698 C  CD  . LYS   A 1  455 ? 1.459   1.623   -39.483 1    31.82   ? 491  LYS   A CD  1 
ATOM   3699 C  CE  . LYS   A 1  455 ? 1.369   0.197   -39.979 1    39.08   ? 491  LYS   A CE  1 
ATOM   3700 N  NZ  . LYS   A 1  455 ? 2.354   -0.497  -39.137 1    37.562  ? 491  LYS   A NZ  1 
ATOM   3701 N  N   . TYR   A 1  456 ? -1.816  4.918   -39.053 1    17.302  ? 492  TYR   A N   1 
ATOM   3702 C  CA  . TYR   A 1  456 ? -3.164  4.415   -38.825 1    19.535  ? 492  TYR   A CA  1 
ATOM   3703 C  C   . TYR   A 1  456 ? -4.249  5.472   -39.078 1    21.434  ? 492  TYR   A C   1 
ATOM   3704 O  O   . TYR   A 1  456 ? -5.29   5.147   -39.659 1    18.219  ? 492  TYR   A O   1 
ATOM   3705 C  CB  . TYR   A 1  456 ? -3.292  3.847   -37.405 1    20.684  ? 492  TYR   A CB  1 
ATOM   3706 C  CG  . TYR   A 1  456 ? -2.46   2.596   -37.245 1    25.492  ? 492  TYR   A CG  1 
ATOM   3707 C  CD1 . TYR   A 1  456 ? -2.789  1.435   -37.95  1    28.328  ? 492  TYR   A CD1 1 
ATOM   3708 C  CD2 . TYR   A 1  456 ? -1.394  2.566   -36.35  1    27.37   ? 492  TYR   A CD2 1 
ATOM   3709 C  CE1 . TYR   A 1  456 ? -2.059  0.272   -37.76  1    28.234  ? 492  TYR   A CE1 1 
ATOM   3710 C  CE2 . TYR   A 1  456 ? -0.673  1.405   -36.145 1    27.758  ? 492  TYR   A CE2 1 
ATOM   3711 C  CZ  . TYR   A 1  456 ? -0.988  0.283   -36.881 1    32.427  ? 492  TYR   A CZ  1 
ATOM   3712 O  OH  . TYR   A 1  456 ? -0.201  -0.794  -36.567 1    44.987  ? 492  TYR   A OH  1 
ATOM   3713 N  N   . GLN   A 1  457 ? -4.059  6.721   -38.604 1    17.131  ? 493  GLN   A N   1 
ATOM   3714 C  CA  . GLN   A 1  457 ? -5.1    7.741   -38.734 1    17.051  ? 493  GLN   A CA  1 
ATOM   3715 C  C   . GLN   A 1  457 ? -4.869  8.638   -39.957 1    19.482  ? 493  GLN   A C   1 
ATOM   3716 O  O   . GLN   A 1  457 ? -5.764  9.337   -40.348 1    19.383  ? 493  GLN   A O   1 
ATOM   3717 C  CB  . GLN   A 1  457 ? -5.135  8.716   -37.546 1    16.709  ? 493  GLN   A CB  1 
ATOM   3718 C  CG  . GLN   A 1  457 ? -5.604  8.174   -36.211 1    16.461  ? 493  GLN   A CG  1 
ATOM   3719 C  CD  . GLN   A 1  457 ? -5.76   9.239   -35.145 1    16.52   ? 493  GLN   A CD  1 
ATOM   3720 O  OE1 . GLN   A 1  457 ? -4.786  9.503   -34.435 1    19.775  ? 493  GLN   A OE1 1 
ATOM   3721 N  NE2 . GLN   A 1  457 ? -6.949  9.847   -34.971 1    17.159  ? 493  GLN   A NE2 1 
ATOM   3722 N  N   . GLY   A 1  458 ? -3.683  8.657   -40.579 1    19.728  ? 494  GLY   A N   1 
ATOM   3723 C  CA  . GLY   A 1  458 ? -3.487  9.572   -41.715 1    18.711  ? 494  GLY   A CA  1 
ATOM   3724 C  C   . GLY   A 1  458 ? -3.506  11.001  -41.22  1    16.519  ? 494  GLY   A C   1 
ATOM   3725 O  O   . GLY   A 1  458 ? -4.029  11.922  -41.894 1    19.662  ? 494  GLY   A O   1 
ATOM   3726 N  N   . LEU   A 1  459 ? -2.905  11.208  -40.04  1    17.697  ? 495  LEU   A N   1 
ATOM   3727 C  CA  . LEU   A 1  459 ? -2.78   12.605  -39.601 1    17.678  ? 495  LEU   A CA  1 
ATOM   3728 C  C   . LEU   A 1  459 ? -1.31   12.963  -39.523 1    18.751  ? 495  LEU   A C   1 
ATOM   3729 O  O   . LEU   A 1  459 ? -0.436  12.078  -39.387 1    20.455  ? 495  LEU   A O   1 
ATOM   3730 C  CB  . LEU   A 1  459 ? -3.375  12.828  -38.2   1    17.049  ? 495  LEU   A CB  1 
ATOM   3731 C  CG  . LEU   A 1  459 ? -4.822  12.388  -38.055 1    18.78   ? 495  LEU   A CG  1 
ATOM   3732 C  CD1 . LEU   A 1  459 ? -5.171  12.497  -36.557 1    17.069  ? 495  LEU   A CD1 1 
ATOM   3733 C  CD2 . LEU   A 1  459 ? -5.682  13.337  -38.882 1    14.438  ? 495  LEU   A CD2 1 
ATOM   3734 N  N   . CYS   A 1  460 ? -1.05   14.3    -39.569 1    18.556  ? 496  CYS   A N   1 
ATOM   3735 C  CA  . CYS   A 1  460 ? 0.302   14.806  -39.418 1    19.091  ? 496  CYS   A CA  1 
ATOM   3736 C  C   . CYS   A 1  460 ? 0.234   15.91   -38.363 1    18.657  ? 496  CYS   A C   1 
ATOM   3737 O  O   . CYS   A 1  460 ? -0.832  16.475  -38.094 1    17.234  ? 496  CYS   A O   1 
ATOM   3738 C  CB  . CYS   A 1  460 ? 0.863   15.362  -40.773 1    18.358  ? 496  CYS   A CB  1 
ATOM   3739 S  SG  . CYS   A 1  460 ? -0.159  16.641  -41.556 1    25.288  ? 496  CYS   A SG  1 
ATOM   3740 N  N   . PRO   A 1  461 ? 1.337   16.218  -37.663 1    19.888  ? 497  PRO   A N   1 
ATOM   3741 C  CA  . PRO   A 1  461 ? 1.297   17.286  -36.665 1    19.634  ? 497  PRO   A CA  1 
ATOM   3742 C  C   . PRO   A 1  461 ? 1.265   18.587  -37.444 1    21.409  ? 497  PRO   A C   1 
ATOM   3743 O  O   . PRO   A 1  461 ? 1.922   18.683  -38.495 1    21.78   ? 497  PRO   A O   1 
ATOM   3744 C  CB  . PRO   A 1  461 ? 2.651   17.103  -35.955 1    20.254  ? 497  PRO   A CB  1 
ATOM   3745 C  CG  . PRO   A 1  461 ? 3.606   16.317  -36.89  1    21.064  ? 497  PRO   A CG  1 
ATOM   3746 C  CD  . PRO   A 1  461 ? 2.636   15.537  -37.759 1    24.204  ? 497  PRO   A CD  1 
ATOM   3747 N  N   . PRO   A 1  462 ? 0.486   19.598  -37.039 1    21.909  ? 498  PRO   A N   1 
ATOM   3748 C  CA  . PRO   A 1  462 ? 0.526   20.862  -37.784 1    24.637  ? 498  PRO   A CA  1 
ATOM   3749 C  C   . PRO   A 1  462 ? 1.841   21.64   -37.665 1    27.54   ? 498  PRO   A C   1 
ATOM   3750 O  O   . PRO   A 1  462 ? 2.145   22.454  -38.549 1    26.193  ? 498  PRO   A O   1 
ATOM   3751 C  CB  . PRO   A 1  462 ? -0.675  21.632  -37.197 1    21.959  ? 498  PRO   A CB  1 
ATOM   3752 C  CG  . PRO   A 1  462 ? -0.789  21.084  -35.798 1    23.322  ? 498  PRO   A CG  1 
ATOM   3753 C  CD  . PRO   A 1  462 ? -0.535  19.589  -35.967 1    18.001  ? 498  PRO   A CD  1 
ATOM   3754 N  N   . VAL   A 1  463 ? 2.619   21.393  -36.585 1    20.028  ? 499  VAL   A N   1 
ATOM   3755 C  CA  . VAL   A 1  463 ? 3.909   22.054  -36.37  1    23.933  ? 499  VAL   A CA  1 
ATOM   3756 C  C   . VAL   A 1  463 ? 4.907   20.909  -36.187 1    23.139  ? 499  VAL   A C   1 
ATOM   3757 O  O   . VAL   A 1  463 ? 4.583   19.904  -35.566 1    25.482  ? 499  VAL   A O   1 
ATOM   3758 C  CB  . VAL   A 1  463 ? 3.747   22.863  -35.061 1    27.206  ? 499  VAL   A CB  1 
ATOM   3759 C  CG1 . VAL   A 1  463 ? 5.067   23.141  -34.353 1    30.028  ? 499  VAL   A CG1 1 
ATOM   3760 C  CG2 . VAL   A 1  463 ? 2.831   24.103  -35.247 1    25.82   ? 499  VAL   A CG2 1 
ATOM   3761 N  N   . PRO   A 1  464 ? 6.105   20.966  -36.775 1    25.362  ? 500  PRO   A N   1 
ATOM   3762 C  CA  . PRO   A 1  464 ? 7.086   19.886  -36.583 1    25.405  ? 500  PRO   A CA  1 
ATOM   3763 C  C   . PRO   A 1  464 ? 7.404   19.759  -35.093 1    26.233  ? 500  PRO   A C   1 
ATOM   3764 O  O   . PRO   A 1  464 ? 7.43    20.735  -34.346 1    27.06   ? 500  PRO   A O   1 
ATOM   3765 C  CB  . PRO   A 1  464 ? 8.257   20.44   -37.468 1    27.544  ? 500  PRO   A CB  1 
ATOM   3766 C  CG  . PRO   A 1  464 ? 7.528   21.186  -38.569 1    29.691  ? 500  PRO   A CG  1 
ATOM   3767 C  CD  . PRO   A 1  464 ? 6.558   22.022  -37.72  1    27.546  ? 500  PRO   A CD  1 
ATOM   3768 N  N   . ARG   A 1  465 ? 7.505   18.52   -34.614 1    21.38   ? 501  ARG   A N   1 
ATOM   3769 C  CA  . ARG   A 1  465 ? 7.782   18.317  -33.214 1    21.809  ? 501  ARG   A CA  1 
ATOM   3770 C  C   . ARG   A 1  465 ? 9.294   18.402  -32.959 1    27.26   ? 501  ARG   A C   1 
ATOM   3771 O  O   . ARG   A 1  465 ? 10.097  18.167  -33.861 1    26.717  ? 501  ARG   A O   1 
ATOM   3772 C  CB  . ARG   A 1  465 ? 7.413   16.872  -32.858 1    20.935  ? 501  ARG   A CB  1 
ATOM   3773 C  CG  . ARG   A 1  465 ? 6.024   16.463  -33.388 1    24.789  ? 501  ARG   A CG  1 
ATOM   3774 C  CD  . ARG   A 1  465 ? 4.899   17.498  -33.242 1    20.875  ? 501  ARG   A CD  1 
ATOM   3775 N  NE  . ARG   A 1  465 ? 4.65    17.845  -31.844 1    15.618  ? 501  ARG   A NE  1 
ATOM   3776 C  CZ  . ARG   A 1  465 ? 4.549   19.085  -31.411 1    18.848  ? 501  ARG   A CZ  1 
ATOM   3777 N  NH1 . ARG   A 1  465 ? 4.681   20.149  -32.198 1    20.496  ? 501  ARG   A NH1 1 
ATOM   3778 N  NH2 . ARG   A 1  465 ? 4.175   19.219  -30.178 1    18.332  ? 501  ARG   A NH2 1 
ATOM   3779 N  N   . THR   A 1  466 ? 9.686   18.727  -31.713 1    29.663  ? 502  THR   A N   1 
ATOM   3780 C  CA  . THR   A 1  466 ? 11.107  18.913  -31.406 1    34.753  ? 502  THR   A CA  1 
ATOM   3781 C  C   . THR   A 1  466 ? 11.467  17.982  -30.262 1    31.939  ? 502  THR   A C   1 
ATOM   3782 O  O   . THR   A 1  466 ? 10.579  17.397  -29.647 1    28.185  ? 502  THR   A O   1 
ATOM   3783 C  CB  . THR   A 1  466 ? 11.437  20.363  -31.029 1    36.991  ? 502  THR   A CB  1 
ATOM   3784 O  OG1 . THR   A 1  466 ? 10.518  20.933  -30.105 1    36.397  ? 502  THR   A OG1 1 
ATOM   3785 C  CG2 . THR   A 1  466 ? 11.453  21.349  -32.173 1    33.492  ? 502  THR   A CG2 1 
ATOM   3786 N  N   . GLN   A 1  467 ? 12.763  17.877  -29.967 1    32.17   ? 503  GLN   A N   1 
ATOM   3787 C  CA  . GLN   A 1  467 ? 13.223  17.099  -28.83  1    37.961  ? 503  GLN   A CA  1 
ATOM   3788 C  C   . GLN   A 1  467 ? 12.587  17.663  -27.56  1    32.631  ? 503  GLN   A C   1 
ATOM   3789 O  O   . GLN   A 1  467 ? 12.412  18.869  -27.408 1    33.989  ? 503  GLN   A O   1 
ATOM   3790 C  CB  . GLN   A 1  467 ? 14.765  17.14   -28.724 1    37.626  ? 503  GLN   A CB  1 
ATOM   3791 C  CG  . GLN   A 1  467 ? 15.301  16.324  -27.541 1    43.049  ? 503  GLN   A CG  1 
ATOM   3792 C  CD  . GLN   A 1  467 ? 15.415  17.119  -26.253 1    44.685  ? 503  GLN   A CD  1 
ATOM   3793 O  OE1 . GLN   A 1  467 ? 15.258  18.344  -26.227 1    51.018  ? 503  GLN   A OE1 1 
ATOM   3794 N  NE2 . GLN   A 1  467 ? 15.709  16.452  -25.149 1    42.567  ? 503  GLN   A NE2 1 
ATOM   3795 N  N   . GLY   A 1  468 ? 12.297  16.825  -26.572 1    27.784  ? 504  GLY   A N   1 
ATOM   3796 C  CA  . GLY   A 1  468 ? 11.568  17.508  -25.512 1    24.13   ? 504  GLY   A CA  1 
ATOM   3797 C  C   . GLY   A 1  468 ? 10.038  17.412  -25.63  1    23.367  ? 504  GLY   A C   1 
ATOM   3798 O  O   . GLY   A 1  468 ? 9.375   17.445  -24.607 1    26.2    ? 504  GLY   A O   1 
ATOM   3799 N  N   . ASP   A 1  469 ? 9.467   17.305  -26.844 1    22.205  ? 505  ASP   A N   1 
ATOM   3800 C  CA  . ASP   A 1  469 ? 8.021   17.082  -26.997 1    23.629  ? 505  ASP   A CA  1 
ATOM   3801 C  C   . ASP   A 1  469 ? 7.672   15.657  -26.572 1    21.624  ? 505  ASP   A C   1 
ATOM   3802 O  O   . ASP   A 1  469 ? 8.425   14.713  -26.847 1    23.048  ? 505  ASP   A O   1 
ATOM   3803 C  CB  . ASP   A 1  469 ? 7.509   17.318  -28.427 1    18.624  ? 505  ASP   A CB  1 
ATOM   3804 C  CG  . ASP   A 1  469 ? 7.451   18.784  -28.788 1    20.284  ? 505  ASP   A CG  1 
ATOM   3805 O  OD1 . ASP   A 1  469 ? 7.457   19.575  -27.842 1    19.405  ? 505  ASP   A OD1 1 
ATOM   3806 O  OD2 . ASP   A 1  469 ? 7.526   19.119  -29.972 1    22.767  ? 505  ASP   A OD2 1 
ATOM   3807 N  N   . PHE   A 1  470 ? 6.53    15.538  -25.891 1    20.081  ? 506  PHE   A N   1 
ATOM   3808 C  CA  . PHE   A 1  470 ? 6.053   14.241  -25.494 1    17.555  ? 506  PHE   A CA  1 
ATOM   3809 C  C   . PHE   A 1  470 ? 4.517   14.334  -25.636 1    18.407  ? 506  PHE   A C   1 
ATOM   3810 O  O   . PHE   A 1  470 ? 3.767   14.403  -24.673 1    17.314  ? 506  PHE   A O   1 
ATOM   3811 C  CB  . PHE   A 1  470 ? 6.489   13.821  -24.084 1    19.562  ? 506  PHE   A CB  1 
ATOM   3812 C  CG  . PHE   A 1  470 ? 6.036   12.426  -23.684 1    16.343  ? 506  PHE   A CG  1 
ATOM   3813 C  CD1 . PHE   A 1  470 ? 6.434   11.316  -24.437 1    17.36   ? 506  PHE   A CD1 1 
ATOM   3814 C  CD2 . PHE   A 1  470 ? 5.244   12.256  -22.558 1    17.672  ? 506  PHE   A CD2 1 
ATOM   3815 C  CE1 . PHE   A 1  470 ? 6.026   10      -24.074 1    20.585  ? 506  PHE   A CE1 1 
ATOM   3816 C  CE2 . PHE   A 1  470 ? 4.793   10.967  -22.209 1    18.911  ? 506  PHE   A CE2 1 
ATOM   3817 C  CZ  . PHE   A 1  470 ? 5.261   9.837   -22.922 1    20.526  ? 506  PHE   A CZ  1 
ATOM   3818 N  N   . ASP   A 1  471 ? 4.087   14.369  -26.882 1    17.218  ? 507  ASP   A N   1 
ATOM   3819 C  CA  . ASP   A 1  471 ? 2.663   14.532  -27.181 1    18.873  ? 507  ASP   A CA  1 
ATOM   3820 C  C   . ASP   A 1  471 ? 1.805   13.443  -26.52  1    17.939  ? 507  ASP   A C   1 
ATOM   3821 O  O   . ASP   A 1  471 ? 0.669   13.771  -26.109 1    18.288  ? 507  ASP   A O   1 
ATOM   3822 C  CB  . ASP   A 1  471 ? 2.527   14.603  -28.703 1    19.147  ? 507  ASP   A CB  1 
ATOM   3823 C  CG  . ASP   A 1  471 ? 3.284   15.781  -29.312 1    20.925  ? 507  ASP   A CG  1 
ATOM   3824 O  OD1 . ASP   A 1  471 ? 3.392   16.808  -28.607 1    20.038  ? 507  ASP   A OD1 1 
ATOM   3825 O  OD2 . ASP   A 1  471 ? 3.859   15.639  -30.419 1    21.592  ? 507  ASP   A OD2 1 
ATOM   3826 N  N   . PRO   A 1  472 ? 2.17    12.116  -26.418 1    16.327  ? 508  PRO   A N   1 
ATOM   3827 C  CA  . PRO   A 1  472 ? 1.307   11.159  -25.723 1    18.492  ? 508  PRO   A CA  1 
ATOM   3828 C  C   . PRO   A 1  472 ? 0.949   11.622  -24.328 1    21.105  ? 508  PRO   A C   1 
ATOM   3829 O  O   . PRO   A 1  472 ? -0.116  11.243  -23.815 1    18.975  ? 508  PRO   A O   1 
ATOM   3830 C  CB  . PRO   A 1  472 ? 2.161   9.819   -25.636 1    15.112  ? 508  PRO   A CB  1 
ATOM   3831 C  CG  . PRO   A 1  472 ? 2.939   9.896   -26.936 1    16.061  ? 508  PRO   A CG  1 
ATOM   3832 C  CD  . PRO   A 1  472 ? 3.364   11.435  -26.951 1    13.299  ? 508  PRO   A CD  1 
ATOM   3833 N  N   . GLY   A 1  473 ? 1.896   12.31   -23.676 1    18.383  ? 509  GLY   A N   1 
ATOM   3834 C  CA  . GLY   A 1  473 ? 1.661   12.811  -22.307 1    17.139  ? 509  GLY   A CA  1 
ATOM   3835 C  C   . GLY   A 1  473 ? 0.432   13.723  -22.235 1    18.423  ? 509  GLY   A C   1 
ATOM   3836 O  O   . GLY   A 1  473 ? -0.184  13.94   -21.167 1    21.142  ? 509  GLY   A O   1 
ATOM   3837 N  N   . ALA   A 1  474 ? 0.061   14.295  -23.378 1    17.07   ? 510  ALA   A N   1 
ATOM   3838 C  CA  . ALA   A 1  474 ? -1.071  15.255  -23.399 1    19.303  ? 510  ALA   A CA  1 
ATOM   3839 C  C   . ALA   A 1  474 ? -2.424  14.552  -23.605 1    16.699  ? 510  ALA   A C   1 
ATOM   3840 O  O   . ALA   A 1  474 ? -3.443  15.224  -23.766 1    16.805  ? 510  ALA   A O   1 
ATOM   3841 C  CB  . ALA   A 1  474 ? -0.851  16.25   -24.559 1    17.552  ? 510  ALA   A CB  1 
ATOM   3842 N  N   . LYS   A 1  475 ? -2.436  13.224  -23.583 1    16.645  ? 511  LYS   A N   1 
ATOM   3843 C  CA  . LYS   A 1  475 ? -3.706  12.495  -23.604 1    17.446  ? 511  LYS   A CA  1 
ATOM   3844 C  C   . LYS   A 1  475 ? -3.833  11.802  -22.241 1    16.502  ? 511  LYS   A C   1 
ATOM   3845 O  O   . LYS   A 1  475 ? -2.97   10.97   -21.877 1    16.364  ? 511  LYS   A O   1 
ATOM   3846 C  CB  . LYS   A 1  475 ? -3.568  11.386  -24.668 1    16.944  ? 511  LYS   A CB  1 
ATOM   3847 C  CG  . LYS   A 1  475 ? -4.741  10.278  -24.806 1    16.32   ? 511  LYS   A CG  1 
ATOM   3848 C  CD  . LYS   A 1  475 ? -6.064  11.057  -25.089 1    15.739  ? 511  LYS   A CD  1 
ATOM   3849 C  CE  . LYS   A 1  475 ? -7.259  10.071  -25.047 1    14.986  ? 511  LYS   A CE  1 
ATOM   3850 N  NZ  . LYS   A 1  475 ? -8.534  10.783  -25.044 1    13.593  ? 511  LYS   A NZ  1 
ATOM   3851 N  N   . PHE   A 1  476 ? -4.984  12.023  -21.599 1    16.417  ? 512  PHE   A N   1 
ATOM   3852 C  CA  . PHE   A 1  476 ? -5.308  11.573  -20.234 1    18.674  ? 512  PHE   A CA  1 
ATOM   3853 C  C   . PHE   A 1  476 ? -4.767  10.178  -19.881 1    16.31   ? 512  PHE   A C   1 
ATOM   3854 O  O   . PHE   A 1  476 ? -4.106  10.026  -18.854 1    19.903  ? 512  PHE   A O   1 
ATOM   3855 C  CB  . PHE   A 1  476 ? -6.83   11.446  -20     1    18.751  ? 512  PHE   A CB  1 
ATOM   3856 C  CG  . PHE   A 1  476 ? -7.205  10.994  -18.594 1    17.943  ? 512  PHE   A CG  1 
ATOM   3857 C  CD1 . PHE   A 1  476 ? -7.194  11.897  -17.505 1    15.519  ? 512  PHE   A CD1 1 
ATOM   3858 C  CD2 . PHE   A 1  476 ? -7.593  9.658   -18.366 1    16.64   ? 512  PHE   A CD2 1 
ATOM   3859 C  CE1 . PHE   A 1  476 ? -7.455  11.429  -16.199 1    17.191  ? 512  PHE   A CE1 1 
ATOM   3860 C  CE2 . PHE   A 1  476 ? -7.921  9.202   -17.076 1    17.209  ? 512  PHE   A CE2 1 
ATOM   3861 C  CZ  . PHE   A 1  476 ? -7.876  10.104  -15.994 1    19.988  ? 512  PHE   A CZ  1 
ATOM   3862 N  N   . HIS   A 1  477 ? -5.05   9.153   -20.702 1    16.705  ? 513  HIS   A N   1 
ATOM   3863 C  CA  . HIS   A 1  477 ? -4.74   7.761   -20.316 1    15.341  ? 513  HIS   A CA  1 
ATOM   3864 C  C   . HIS   A 1  477 ? -3.258  7.477   -20.206 1    15.979  ? 513  HIS   A C   1 
ATOM   3865 O  O   . HIS   A 1  477 ? -2.868  6.435   -19.628 1    17.157  ? 513  HIS   A O   1 
ATOM   3866 C  CB  . HIS   A 1  477 ? -5.329  6.77    -21.346 1    15.037  ? 513  HIS   A CB  1 
ATOM   3867 C  CG  . HIS   A 1  477 ? -6.842  7.008   -21.441 1    14.155  ? 513  HIS   A CG  1 
ATOM   3868 N  ND1 . HIS   A 1  477 ? -7.387  8.177   -21.929 1    13.743  ? 513  HIS   A ND1 1 
ATOM   3869 C  CD2 . HIS   A 1  477 ? -7.866  6.232   -21.023 1    13.801  ? 513  HIS   A CD2 1 
ATOM   3870 C  CE1 . HIS   A 1  477 ? -8.735  8.107   -21.875 1    13.391  ? 513  HIS   A CE1 1 
ATOM   3871 N  NE2 . HIS   A 1  477 ? -9.073  6.912   -21.324 1    14.242  ? 513  HIS   A NE2 1 
ATOM   3872 N  N   . ILE   A 1  478 ? -2.462  8.314   -20.841 1    15.158  ? 514  ILE   A N   1 
ATOM   3873 C  CA  . ILE   A 1  478 ? -1.032  8.073   -20.781 1    14.432  ? 514  ILE   A CA  1 
ATOM   3874 C  C   . ILE   A 1  478 ? -0.481  8.376   -19.383 1    17.171  ? 514  ILE   A C   1 
ATOM   3875 O  O   . ILE   A 1  478 ? 0.039   7.48    -18.733 1    17.26   ? 514  ILE   A O   1 
ATOM   3876 C  CB  . ILE   A 1  478 ? -0.279  8.793   -21.915 1    14.53   ? 514  ILE   A CB  1 
ATOM   3877 C  CG1 . ILE   A 1  478 ? -0.78   8.329   -23.35  1    17.932  ? 514  ILE   A CG1 1 
ATOM   3878 C  CG2 . ILE   A 1  478 ? 1.252   8.679   -21.759 1    17.909  ? 514  ILE   A CG2 1 
ATOM   3879 C  CD1 . ILE   A 1  478 ? -0.469  6.888   -23.596 1    21.284  ? 514  ILE   A CD1 1 
ATOM   3880 N  N   . PRO   A 1  479 ? -0.5    9.631   -18.892 1    17.111  ? 515  PRO   A N   1 
ATOM   3881 C  CA  . PRO   A 1  479 ? -0.097  9.909   -17.498 1    19.254  ? 515  PRO   A CA  1 
ATOM   3882 C  C   . PRO   A 1  479 ? -0.919  9.09    -16.486 1    22.077  ? 515  PRO   A C   1 
ATOM   3883 O  O   . PRO   A 1  479 ? -0.457  8.822   -15.345 1    22.289  ? 515  PRO   A O   1 
ATOM   3884 C  CB  . PRO   A 1  479 ? -0.296  11.434  -17.309 1    18.708  ? 515  PRO   A CB  1 
ATOM   3885 C  CG  . PRO   A 1  479 ? -1.042  11.887  -18.596 1    20.391  ? 515  PRO   A CG  1 
ATOM   3886 C  CD  . PRO   A 1  479 ? -0.714  10.848  -19.673 1    15.008  ? 515  PRO   A CD  1 
ATOM   3887 N  N   . SER   A 1  480 ? -2.203  8.78    -16.804 1    17.524  ? 516  SER   A N   1 
ATOM   3888 C  CA  . SER   A 1  480 ? -3.007  8.086   -15.807 1    17.609  ? 516  SER   A CA  1 
ATOM   3889 C  C   . SER   A 1  480 ? -2.768  6.592   -15.834 1    18.687  ? 516  SER   A C   1 
ATOM   3890 O  O   . SER   A 1  480 ? -3.425  5.937   -15.031 1    18.585  ? 516  SER   A O   1 
ATOM   3891 C  CB  . SER   A 1  480 ? -4.507  8.299   -16.017 1    20.453  ? 516  SER   A CB  1 
ATOM   3892 O  OG  . SER   A 1  480 ? -4.755  9.643   -15.608 1    27.773  ? 516  SER   A OG  1 
ATOM   3893 N  N   . SER   A 1  481 ? -2.008  6.092   -16.82  1    16.43   ? 517  SER   A N   1 
ATOM   3894 C  CA  . SER   A 1  481 ? -1.674  4.657   -16.892 1    17.853  ? 517  SER   A CA  1 
ATOM   3895 C  C   . SER   A 1  481 ? -2.946  3.802   -17.001 1    21.229  ? 517  SER   A C   1 
ATOM   3896 O  O   . SER   A 1  481 ? -3.19   2.882   -16.241 1    19.817  ? 517  SER   A O   1 
ATOM   3897 C  CB  . SER   A 1  481 ? -0.834  4.228   -15.675 1    14.98   ? 517  SER   A CB  1 
ATOM   3898 O  OG  . SER   A 1  481 ? -0.315  2.93    -16.002 1    17.466  ? 517  SER   A OG  1 
ATOM   3899 N  N   . VAL   A 1  482 ? -3.84   4.171   -17.914 1    20.024  ? 518  VAL   A N   1 
ATOM   3900 C  CA  . VAL   A 1  482 ? -5.091  3.494   -18.119 1    17.371  ? 518  VAL   A CA  1 
ATOM   3901 C  C   . VAL   A 1  482 ? -5.003  2.848   -19.498 1    15.365  ? 518  VAL   A C   1 
ATOM   3902 O  O   . VAL   A 1  482 ? -4.792  3.534   -20.501 1    16.49   ? 518  VAL   A O   1 
ATOM   3903 C  CB  . VAL   A 1  482 ? -6.335  4.398   -18.07  1    17.102  ? 518  VAL   A CB  1 
ATOM   3904 C  CG1 . VAL   A 1  482 ? -7.589  3.562   -18.449 1    17.51   ? 518  VAL   A CG1 1 
ATOM   3905 C  CG2 . VAL   A 1  482 ? -6.488  5.008   -16.689 1    19.542  ? 518  VAL   A CG2 1 
ATOM   3906 N  N   . PRO   A 1  483 ? -5.158  1.508   -19.606 1    13.392  ? 519  PRO   A N   1 
ATOM   3907 C  CA  . PRO   A 1  483 ? -5.054  0.866   -20.935 1    13.973  ? 519  PRO   A CA  1 
ATOM   3908 C  C   . PRO   A 1  483 ? -6.037  1.474   -21.952 1    15.771  ? 519  PRO   A C   1 
ATOM   3909 O  O   . PRO   A 1  483 ? -7.102  1.949   -21.541 1    16.47   ? 519  PRO   A O   1 
ATOM   3910 C  CB  . PRO   A 1  483 ? -5.372  -0.648  -20.651 1    12.57   ? 519  PRO   A CB  1 
ATOM   3911 C  CG  . PRO   A 1  483 ? -4.988  -0.802  -19.134 1    17.429  ? 519  PRO   A CG  1 
ATOM   3912 C  CD  . PRO   A 1  483 ? -5.391  0.589   -18.462 1    18.44   ? 519  PRO   A CD  1 
ATOM   3913 N  N   . TYR   A 1  484 ? -5.729  1.428   -23.265 1    16.321  ? 520  TYR   A N   1 
ATOM   3914 C  CA  . TYR   A 1  484 ? -6.612  2.107   -24.239 1    16.179  ? 520  TYR   A CA  1 
ATOM   3915 C  C   . TYR   A 1  484 ? -7.206  1.108   -25.253 1    17.684  ? 520  TYR   A C   1 
ATOM   3916 O  O   . TYR   A 1  484 ? -8.254  1.359   -25.874 1    16.764  ? 520  TYR   A O   1 
ATOM   3917 C  CB  . TYR   A 1  484 ? -5.771  3.178   -24.984 1    16.233  ? 520  TYR   A CB  1 
ATOM   3918 C  CG  . TYR   A 1  484 ? -6.688  4.319   -25.437 1    16.544  ? 520  TYR   A CG  1 
ATOM   3919 C  CD1 . TYR   A 1  484 ? -7.031  5.298   -24.498 1    15.136  ? 520  TYR   A CD1 1 
ATOM   3920 C  CD2 . TYR   A 1  484 ? -7.324  4.319   -26.682 1    16.829  ? 520  TYR   A CD2 1 
ATOM   3921 C  CE1 . TYR   A 1  484 ? -7.946  6.277   -24.859 1    17.167  ? 520  TYR   A CE1 1 
ATOM   3922 C  CE2 . TYR   A 1  484 ? -8.183  5.34    -27.061 1    18.654  ? 520  TYR   A CE2 1 
ATOM   3923 C  CZ  . TYR   A 1  484 ? -8.489  6.325   -26.136 1    16.87   ? 520  TYR   A CZ  1 
ATOM   3924 O  OH  . TYR   A 1  484 ? -9.383  7.304   -26.412 1    15.923  ? 520  TYR   A OH  1 
ATOM   3925 N  N   . ILE   A 1  485 ? -6.598  -0.105  -25.428 1    14.447  ? 521  ILE   A N   1 
ATOM   3926 C  CA  . ILE   A 1  485 ? -7.13   -1.034  -26.426 1    15.927  ? 521  ILE   A CA  1 
ATOM   3927 C  C   . ILE   A 1  485 ? -8.59   -1.423  -26.095 1    17.049  ? 521  ILE   A C   1 
ATOM   3928 O  O   . ILE   A 1  485 ? -9.358  -1.694  -27.028 1    16.163  ? 521  ILE   A O   1 
ATOM   3929 C  CB  . ILE   A 1  485 ? -6.207  -2.275  -26.602 1    16.871  ? 521  ILE   A CB  1 
ATOM   3930 C  CG1 . ILE   A 1  485 ? -6.444  -2.962  -27.971 1    20.98   ? 521  ILE   A CG1 1 
ATOM   3931 C  CG2 . ILE   A 1  485 ? -6.325  -3.276  -25.418 1    14.133  ? 521  ILE   A CG2 1 
ATOM   3932 C  CD1 . ILE   A 1  485 ? -6.155  -2.022  -29.151 1    22.344  ? 521  ILE   A CD1 1 
ATOM   3933 N  N   . ARG   A 1  486 ? -8.992  -1.404  -24.794 1    16.05   ? 522  ARG   A N   1 
ATOM   3934 C  CA  . ARG   A 1  486 ? -10.384 -1.532  -24.388 1    17.952  ? 522  ARG   A CA  1 
ATOM   3935 C  C   . ARG   A 1  486 ? -11.342 -0.709  -25.288 1    17.92   ? 522  ARG   A C   1 
ATOM   3936 O  O   . ARG   A 1  486 ? -12.481 -1.14   -25.49  1    15.306  ? 522  ARG   A O   1 
ATOM   3937 C  CB  . ARG   A 1  486 ? -10.534 -1.133  -22.901 1    17.072  ? 522  ARG   A CB  1 
ATOM   3938 C  CG  . ARG   A 1  486 ? -9.903  0.25    -22.629 1    15.942  ? 522  ARG   A CG  1 
ATOM   3939 C  CD  . ARG   A 1  486 ? -10.277 0.858   -21.277 1    17.271  ? 522  ARG   A CD  1 
ATOM   3940 N  NE  . ARG   A 1  486 ? -9.618  0.019   -20.273 1    17.179  ? 522  ARG   A NE  1 
ATOM   3941 C  CZ  . ARG   A 1  486 ? -9.727  0.412   -18.981 1    21.967  ? 522  ARG   A CZ  1 
ATOM   3942 N  NH1 . ARG   A 1  486 ? -10.52  1.431   -18.625 1    22.143  ? 522  ARG   A NH1 1 
ATOM   3943 N  NH2 . ARG   A 1  486 ? -9.076  -0.258  -18.056 1    21.921  ? 522  ARG   A NH2 1 
ATOM   3944 N  N   . TYR   A 1  487 ? -10.914 0.491   -25.751 1    15.607  ? 523  TYR   A N   1 
ATOM   3945 C  CA  . TYR   A 1  487 ? -11.812 1.379   -26.467 1    18.88   ? 523  TYR   A CA  1 
ATOM   3946 C  C   . TYR   A 1  487 ? -12.012 0.874   -27.898 1    15.816  ? 523  TYR   A C   1 
ATOM   3947 O  O   . TYR   A 1  487 ? -13.074 0.995   -28.469 1    15.589  ? 523  TYR   A O   1 
ATOM   3948 C  CB  . TYR   A 1  487 ? -11.418 2.876   -26.398 1    13.96   ? 523  TYR   A CB  1 
ATOM   3949 C  CG  . TYR   A 1  487 ? -11.359 3.327   -24.94  1    16.247  ? 523  TYR   A CG  1 
ATOM   3950 C  CD1 . TYR   A 1  487 ? -12.521 3.536   -24.192 1    17.345  ? 523  TYR   A CD1 1 
ATOM   3951 C  CD2 . TYR   A 1  487 ? -10.118 3.574   -24.309 1    17.624  ? 523  TYR   A CD2 1 
ATOM   3952 C  CE1 . TYR   A 1  487 ? -12.441 4.054   -22.897 1    15.162  ? 523  TYR   A CE1 1 
ATOM   3953 C  CE2 . TYR   A 1  487 ? -10.028 4.041   -23.002 1    15.425  ? 523  TYR   A CE2 1 
ATOM   3954 C  CZ  . TYR   A 1  487 ? -11.211 4.304   -22.326 1    15.195  ? 523  TYR   A CZ  1 
ATOM   3955 O  OH  . TYR   A 1  487 ? -11.155 4.743   -21.011 1    17.84   ? 523  TYR   A OH  1 
ATOM   3956 N  N   . PHE   A 1  488 ? -10.96  0.333   -28.486 1    15.281  ? 524  PHE   A N   1 
ATOM   3957 C  CA  . PHE   A 1  488 ? -11.06  -0.302  -29.799 1    16.285  ? 524  PHE   A CA  1 
ATOM   3958 C  C   . PHE   A 1  488 ? -11.967 -1.505  -29.726 1    17.966  ? 524  PHE   A C   1 
ATOM   3959 O  O   . PHE   A 1  488 ? -12.862 -1.663  -30.583 1    17.846  ? 524  PHE   A O   1 
ATOM   3960 C  CB  . PHE   A 1  488 ? -9.652  -0.706  -30.277 1    14.32   ? 524  PHE   A CB  1 
ATOM   3961 C  CG  . PHE   A 1  488 ? -9.672  -1.369  -31.627 1    16.588  ? 524  PHE   A CG  1 
ATOM   3962 C  CD1 . PHE   A 1  488 ? -9.615  -0.628  -32.811 1    17.466  ? 524  PHE   A CD1 1 
ATOM   3963 C  CD2 . PHE   A 1  488 ? -9.786  -2.759  -31.698 1    17.755  ? 524  PHE   A CD2 1 
ATOM   3964 C  CE1 . PHE   A 1  488 ? -9.623  -1.215  -34.054 1    16.176  ? 524  PHE   A CE1 1 
ATOM   3965 C  CE2 . PHE   A 1  488 ? -9.76   -3.374  -32.948 1    18.411  ? 524  PHE   A CE2 1 
ATOM   3966 C  CZ  . PHE   A 1  488 ? -9.722  -2.608  -34.135 1    18.014  ? 524  PHE   A CZ  1 
ATOM   3967 N  N   . VAL   A 1  489 ? -11.753 -2.331  -28.693 1    16.514  ? 525  VAL   A N   1 
ATOM   3968 C  CA  . VAL   A 1  489 ? -12.601 -3.519  -28.527 1    16.284  ? 525  VAL   A CA  1 
ATOM   3969 C  C   . VAL   A 1  489 ? -14.048 -3.024  -28.371 1    19.675  ? 525  VAL   A C   1 
ATOM   3970 O  O   . VAL   A 1  489 ? -14.961 -3.507  -29.073 1    18.036  ? 525  VAL   A O   1 
ATOM   3971 C  CB  . VAL   A 1  489 ? -12.121 -4.423  -27.37  1    17.353  ? 525  VAL   A CB  1 
ATOM   3972 C  CG1 . VAL   A 1  489 ? -13.112 -5.568  -27.116 1    18.298  ? 525  VAL   A CG1 1 
ATOM   3973 C  CG2 . VAL   A 1  489 ? -10.733 -4.971  -27.745 1    14.611  ? 525  VAL   A CG2 1 
ATOM   3974 N  N   . SER   A 1  490 ? -14.236 -1.996  -27.514 1    14.924  ? 526  SER   A N   1 
ATOM   3975 C  CA  . SER   A 1  490 ? -15.546 -1.42   -27.281 1    19.018  ? 526  SER   A CA  1 
ATOM   3976 C  C   . SER   A 1  490 ? -16.241 -1      -28.582 1    17.502  ? 526  SER   A C   1 
ATOM   3977 O  O   . SER   A 1  490 ? -17.418 -1.238  -28.718 1    15.457  ? 526  SER   A O   1 
ATOM   3978 C  CB  . SER   A 1  490 ? -15.453 -0.23   -26.352 1    18.988  ? 526  SER   A CB  1 
ATOM   3979 O  OG  . SER   A 1  490 ? -16.752 0.213   -26.109 1    17.498  ? 526  SER   A OG  1 
ATOM   3980 N  N   . PHE   A 1  491 ? -15.537 -0.244  -29.438 1    19.494  ? 527  PHE   A N   1 
ATOM   3981 C  CA  . PHE   A 1  491 ? -16.15  0.322   -30.624 1    17.457  ? 527  PHE   A CA  1 
ATOM   3982 C  C   . PHE   A 1  491 ? -16.625 -0.829  -31.542 1    20.38   ? 527  PHE   A C   1 
ATOM   3983 O  O   . PHE   A 1  491 ? -17.677 -0.736  -32.16  1    22.388  ? 527  PHE   A O   1 
ATOM   3984 C  CB  . PHE   A 1  491 ? -15.374 1.477   -31.292 1    16.071  ? 527  PHE   A CB  1 
ATOM   3985 C  CG  . PHE   A 1  491 ? -15.621 2.826   -30.622 1    17.854  ? 527  PHE   A CG  1 
ATOM   3986 C  CD1 . PHE   A 1  491 ? -15.676 2.91    -29.228 1    22.121  ? 527  PHE   A CD1 1 
ATOM   3987 C  CD2 . PHE   A 1  491 ? -15.942 3.951   -31.374 1    20.619  ? 527  PHE   A CD2 1 
ATOM   3988 C  CE1 . PHE   A 1  491 ? -15.915 4.116   -28.6   1    21.509  ? 527  PHE   A CE1 1 
ATOM   3989 C  CE2 . PHE   A 1  491 ? -16.17  5.178   -30.753 1    22.772  ? 527  PHE   A CE2 1 
ATOM   3990 C  CZ  . PHE   A 1  491 ? -16.179 5.249   -29.385 1    21.767  ? 527  PHE   A CZ  1 
ATOM   3991 N  N   . ILE   A 1  492 ? -15.884 -1.917  -31.662 1    19.469  ? 528  ILE   A N   1 
ATOM   3992 C  CA  . ILE   A 1  492 ? -16.332 -3.046  -32.503 1    18.36   ? 528  ILE   A CA  1 
ATOM   3993 C  C   . ILE   A 1  492 ? -17.555 -3.703  -31.854 1    20.873  ? 528  ILE   A C   1 
ATOM   3994 O  O   . ILE   A 1  492 ? -18.622 -3.873  -32.475 1    21.754  ? 528  ILE   A O   1 
ATOM   3995 C  CB  . ILE   A 1  492 ? -15.203 -4.064  -32.693 1    19.985  ? 528  ILE   A CB  1 
ATOM   3996 C  CG1 . ILE   A 1  492 ? -13.952 -3.442  -33.417 1    20.428  ? 528  ILE   A CG1 1 
ATOM   3997 C  CG2 . ILE   A 1  492 ? -15.713 -5.361  -33.376 1    20.971  ? 528  ILE   A CG2 1 
ATOM   3998 C  CD1 . ILE   A 1  492 ? -14.172 -3.062  -34.872 1    20.193  ? 528  ILE   A CD1 1 
ATOM   3999 N  N   . ILE   A 1  493 ? -17.402 -4.112  -30.581 1    21.06   ? 529  ILE   A N   1 
ATOM   4000 C  CA  . ILE   A 1  493 ? -18.393 -4.987  -29.996 1    19.467  ? 529  ILE   A CA  1 
ATOM   4001 C  C   . ILE   A 1  493 ? -19.675 -4.226  -29.729 1    20.535  ? 529  ILE   A C   1 
ATOM   4002 O  O   . ILE   A 1  493 ? -20.742 -4.818  -29.73  1    19.576  ? 529  ILE   A O   1 
ATOM   4003 C  CB  . ILE   A 1  493 ? -17.87  -5.719  -28.735 1    20.899  ? 529  ILE   A CB  1 
ATOM   4004 C  CG1 . ILE   A 1  493 ? -17.708 -4.802  -27.498 1    17.623  ? 529  ILE   A CG1 1 
ATOM   4005 C  CG2 . ILE   A 1  493 ? -16.619 -6.55   -29.067 1    16.914  ? 529  ILE   A CG2 1 
ATOM   4006 C  CD1 . ILE   A 1  493 ? -17.294 -5.626  -26.271 1    16.655  ? 529  ILE   A CD1 1 
ATOM   4007 N  N   . GLN   A 1  494 ? -19.61  -2.897  -29.514 1    17.899  ? 530  GLN   A N   1 
ATOM   4008 C  CA  . GLN   A 1  494 ? -20.871 -2.234  -29.184 1    17.443  ? 530  GLN   A CA  1 
ATOM   4009 C  C   . GLN   A 1  494 ? -21.862 -2.31   -30.363 1    19.055  ? 530  GLN   A C   1 
ATOM   4010 O  O   . GLN   A 1  494 ? -23.08  -2.308  -30.125 1    18.747  ? 530  GLN   A O   1 
ATOM   4011 C  CB  . GLN   A 1  494 ? -20.647 -0.771  -28.731 1    17.422  ? 530  GLN   A CB  1 
ATOM   4012 C  CG  . GLN   A 1  494 ? -20.107 0.136   -29.828 1    16.127  ? 530  GLN   A CG  1 
ATOM   4013 C  CD  . GLN   A 1  494 ? -19.672 1.497   -29.311 1    20.071  ? 530  GLN   A CD  1 
ATOM   4014 O  OE1 . GLN   A 1  494 ? -20.171 2.544   -29.744 1    16.908  ? 530  GLN   A OE1 1 
ATOM   4015 N  NE2 . GLN   A 1  494 ? -18.765 1.483   -28.326 1    17.37   ? 530  GLN   A NE2 1 
ATOM   4016 N  N   . PHE   A 1  495 ? -21.34  -2.352  -31.62  1    18.388  ? 531  PHE   A N   1 
ATOM   4017 C  CA  . PHE   A 1  495 ? -22.199 -2.462  -32.779 1    17.45   ? 531  PHE   A CA  1 
ATOM   4018 C  C   . PHE   A 1  495 ? -22.802 -3.873  -32.8   1    18.974  ? 531  PHE   A C   1 
ATOM   4019 O  O   . PHE   A 1  495 ? -23.986 -4.038  -33.112 1    18.661  ? 531  PHE   A O   1 
ATOM   4020 C  CB  . PHE   A 1  495 ? -21.463 -2.073  -34.073 1    15.056  ? 531  PHE   A CB  1 
ATOM   4021 C  CG  . PHE   A 1  495 ? -21.384 -0.551  -34.17  1    18.077  ? 531  PHE   A CG  1 
ATOM   4022 C  CD1 . PHE   A 1  495 ? -22.422 0.197   -34.759 1    19.171  ? 531  PHE   A CD1 1 
ATOM   4023 C  CD2 . PHE   A 1  495 ? -20.268 0.128   -33.698 1    18.989  ? 531  PHE   A CD2 1 
ATOM   4024 C  CE1 . PHE   A 1  495 ? -22.382 1.614   -34.783 1    21.668  ? 531  PHE   A CE1 1 
ATOM   4025 C  CE2 . PHE   A 1  495 ? -20.231 1.523   -33.713 1    20.673  ? 531  PHE   A CE2 1 
ATOM   4026 C  CZ  . PHE   A 1  495 ? -21.268 2.27    -34.245 1    21.134  ? 531  PHE   A CZ  1 
ATOM   4027 N  N   . GLN   A 1  496 ? -21.962 -4.901  -32.55  1    19.343  ? 532  GLN   A N   1 
ATOM   4028 C  CA  . GLN   A 1  496 ? -22.458 -6.268  -32.366 1    18.139  ? 532  GLN   A CA  1 
ATOM   4029 C  C   . GLN   A 1  496 ? -23.57  -6.326  -31.336 1    20.115  ? 532  GLN   A C   1 
ATOM   4030 O  O   . GLN   A 1  496 ? -24.609 -6.95   -31.601 1    18.35   ? 532  GLN   A O   1 
ATOM   4031 C  CB  . GLN   A 1  496 ? -21.375 -7.232  -31.915 1    19.356  ? 532  GLN   A CB  1 
ATOM   4032 C  CG  . GLN   A 1  496 ? -20.267 -7.364  -32.975 1    21.662  ? 532  GLN   A CG  1 
ATOM   4033 C  CD  . GLN   A 1  496 ? -19.156 -8.293  -32.543 1    25.875  ? 532  GLN   A CD  1 
ATOM   4034 O  OE1 . GLN   A 1  496 ? -18.078 -7.847  -32.095 1    24.027  ? 532  GLN   A OE1 1 
ATOM   4035 N  NE2 . GLN   A 1  496 ? -19.466 -9.596  -32.583 1    24.32   ? 532  GLN   A NE2 1 
ATOM   4036 N  N   . PHE   A 1  497 ? -23.389 -5.627  -30.201 1    21.851  ? 533  PHE   A N   1 
ATOM   4037 C  CA  . PHE   A 1  497 ? -24.41  -5.623  -29.168 1    18.83   ? 533  PHE   A CA  1 
ATOM   4038 C  C   . PHE   A 1  497 ? -25.638 -4.872  -29.686 1    24.164  ? 533  PHE   A C   1 
ATOM   4039 O  O   . PHE   A 1  497 ? -26.754 -5.333  -29.528 1    21.451  ? 533  PHE   A O   1 
ATOM   4040 C  CB  . PHE   A 1  497 ? -23.963 -4.976  -27.864 1    22.344  ? 533  PHE   A CB  1 
ATOM   4041 C  CG  . PHE   A 1  497 ? -22.81  -5.699  -27.176 1    22.853  ? 533  PHE   A CG  1 
ATOM   4042 C  CD1 . PHE   A 1  497 ? -22.357 -6.942  -27.643 1    20.871  ? 533  PHE   A CD1 1 
ATOM   4043 C  CD2 . PHE   A 1  497 ? -22.135 -5.083  -26.124 1    23.059  ? 533  PHE   A CD2 1 
ATOM   4044 C  CE1 . PHE   A 1  497 ? -21.271 -7.582  -27.031 1    20.796  ? 533  PHE   A CE1 1 
ATOM   4045 C  CE2 . PHE   A 1  497 ? -21.096 -5.736  -25.484 1    22.549  ? 533  PHE   A CE2 1 
ATOM   4046 C  CZ  . PHE   A 1  497 ? -20.718 -7.013  -25.893 1    20.835  ? 533  PHE   A CZ  1 
ATOM   4047 N  N   . HIS   A 1  498 ? -25.495 -3.675  -30.267 1    21.886  ? 534  HIS   A N   1 
ATOM   4048 C  CA  . HIS   A 1  498 ? -26.676 -2.97   -30.785 1    18.57   ? 534  HIS   A CA  1 
ATOM   4049 C  C   . HIS   A 1  498 ? -27.451 -3.87   -31.792 1    20.232  ? 534  HIS   A C   1 
ATOM   4050 O  O   . HIS   A 1  498 ? -28.659 -4.034  -31.678 1    20.513  ? 534  HIS   A O   1 
ATOM   4051 C  CB  . HIS   A 1  498 ? -26.115 -1.739  -31.523 1    19.648  ? 534  HIS   A CB  1 
ATOM   4052 C  CG  . HIS   A 1  498 ? -27.135 -0.818  -32.077 1    19.138  ? 534  HIS   A CG  1 
ATOM   4053 N  ND1 . HIS   A 1  498 ? -28.063 -0.101  -31.341 1    18.008  ? 534  HIS   A ND1 1 
ATOM   4054 C  CD2 . HIS   A 1  498 ? -27.353 -0.5    -33.393 1    21.171  ? 534  HIS   A CD2 1 
ATOM   4055 C  CE1 . HIS   A 1  498 ? -28.754 0.669   -32.165 1    15.956  ? 534  HIS   A CE1 1 
ATOM   4056 N  NE2 . HIS   A 1  498 ? -28.363 0.427   -33.414 1    17.123  ? 534  HIS   A NE2 1 
ATOM   4057 N  N   . GLU   A 1  499 ? -26.772 -4.484  -32.763 1    21.456  ? 535  GLU   A N   1 
ATOM   4058 C  CA  . GLU   A 1  499 ? -27.365 -5.4    -33.745 1    21.009  ? 535  GLU   A CA  1 
ATOM   4059 C  C   . GLU   A 1  499 ? -28.174 -6.528  -33.061 1    27.172  ? 535  GLU   A C   1 
ATOM   4060 O  O   . GLU   A 1  499 ? -29.341 -6.768  -33.361 1    20.265  ? 535  GLU   A O   1 
ATOM   4061 C  CB  . GLU   A 1  499 ? -26.323 -5.852  -34.772 1    18.889  ? 535  GLU   A CB  1 
ATOM   4062 C  CG  . GLU   A 1  499 ? -26.791 -6.968  -35.741 1    24.269  ? 535  GLU   A CG  1 
ATOM   4063 C  CD  . GLU   A 1  499 ? -25.644 -7.587  -36.522 1    25.917  ? 535  GLU   A CD  1 
ATOM   4064 O  OE1 . GLU   A 1  499 ? -24.828 -8.324  -36.011 1    28.051  ? 535  GLU   A OE1 1 
ATOM   4065 O  OE2 . GLU   A 1  499 ? -25.455 -7.259  -37.656 1    29.012  ? 535  GLU   A OE2 1 
ATOM   4066 N  N   . ALA   A 1  500 ? -27.579 -7.21   -32.076 1    24.976  ? 536  ALA   A N   1 
ATOM   4067 C  CA  . ALA   A 1  500 ? -28.284 -8.288  -31.38  1    23.296  ? 536  ALA   A CA  1 
ATOM   4068 C  C   . ALA   A 1  500 ? -29.423 -7.735  -30.524 1    23.498  ? 536  ALA   A C   1 
ATOM   4069 O  O   . ALA   A 1  500 ? -30.51  -8.332  -30.481 1    26.599  ? 536  ALA   A O   1 
ATOM   4070 C  CB  . ALA   A 1  500 ? -27.32  -9.103  -30.55  1    19.639  ? 536  ALA   A CB  1 
ATOM   4071 N  N   . LEU   A 1  501 ? -29.196 -6.624  -29.824 1    21.539  ? 537  LEU   A N   1 
ATOM   4072 C  CA  . LEU   A 1  501 ? -30.272 -6.052  -29.038 1    21.435  ? 537  LEU   A CA  1 
ATOM   4073 C  C   . LEU   A 1  501 ? -31.456 -5.648  -29.917 1    27.844  ? 537  LEU   A C   1 
ATOM   4074 O  O   . LEU   A 1  501 ? -32.616 -5.863  -29.501 1    25.345  ? 537  LEU   A O   1 
ATOM   4075 C  CB  . LEU   A 1  501 ? -29.868 -4.933  -28.066 1    23.136  ? 537  LEU   A CB  1 
ATOM   4076 C  CG  . LEU   A 1  501 ? -28.802 -5.334  -27.045 1    28.503  ? 537  LEU   A CG  1 
ATOM   4077 C  CD1 . LEU   A 1  501 ? -28.541 -4.229  -26.01  1    26.44   ? 537  LEU   A CD1 1 
ATOM   4078 C  CD2 . LEU   A 1  501 ? -29.229 -6.596  -26.421 1    23.927  ? 537  LEU   A CD2 1 
ATOM   4079 N  N   . CYS   A 1  502 ? -31.152 -5.055  -31.094 1    23.839  ? 538  CYS   A N   1 
ATOM   4080 C  CA  . CYS   A 1  502 ? -32.162 -4.539  -32.004 1    26.018  ? 538  CYS   A CA  1 
ATOM   4081 C  C   . CYS   A 1  502 ? -32.973 -5.731  -32.522 1    27.183  ? 538  CYS   A C   1 
ATOM   4082 O  O   . CYS   A 1  502 ? -34.213 -5.68   -32.541 1    25.782  ? 538  CYS   A O   1 
ATOM   4083 C  CB  . CYS   A 1  502 ? -31.507 -3.744  -33.121 1    25.504  ? 538  CYS   A CB  1 
ATOM   4084 S  SG  . CYS   A 1  502 ? -30.831 -2.217  -32.445 1    23.663  ? 538  CYS   A SG  1 
ATOM   4085 N  N   . GLN   A 1  503 ? -32.287 -6.833  -32.847 1    27.154  ? 539  GLN   A N   1 
ATOM   4086 C  CA  . GLN   A 1  503 ? -32.971 -8.085  -33.18  1    33.282  ? 539  GLN   A CA  1 
ATOM   4087 C  C   . GLN   A 1  503 ? -33.811 -8.597  -32     1    31.996  ? 539  GLN   A C   1 
ATOM   4088 O  O   . GLN   A 1  503 ? -34.999 -8.789  -32.14  1    33.999  ? 539  GLN   A O   1 
ATOM   4089 C  CB  . GLN   A 1  503 ? -32.046 -9.11   -33.816 1    33.804  ? 539  GLN   A CB  1 
ATOM   4090 C  CG  . GLN   A 1  503 ? -32.782 -10.044 -34.772 1    54.436  ? 539  GLN   A CG  1 
ATOM   4091 C  CD  . GLN   A 1  503 ? -32.433 -11.483 -34.487 1    61.381  ? 539  GLN   A CD  1 
ATOM   4092 O  OE1 . GLN   A 1  503 ? -32.51  -11.909 -33.336 1    77.49   ? 539  GLN   A OE1 1 
ATOM   4093 N  NE2 . GLN   A 1  503 ? -31.973 -12.218 -35.488 1    57.147  ? 539  GLN   A NE2 1 
ATOM   4094 N  N   . ALA   A 1  504 ? -33.258 -8.747  -30.798 1    29.8    ? 540  ALA   A N   1 
ATOM   4095 C  CA  . ALA   A 1  504 ? -34.057 -9.044  -29.611 1    28.009  ? 540  ALA   A CA  1 
ATOM   4096 C  C   . ALA   A 1  504 ? -35.29  -8.142  -29.481 1    31.731  ? 540  ALA   A C   1 
ATOM   4097 O  O   . ALA   A 1  504 ? -36.348 -8.617  -29.099 1    29.787  ? 540  ALA   A O   1 
ATOM   4098 C  CB  . ALA   A 1  504 ? -33.199 -8.927  -28.36  1    31.594  ? 540  ALA   A CB  1 
ATOM   4099 N  N   . ALA   A 1  505 ? -35.171 -6.833  -29.78  1    29.924  ? 541  ALA   A N   1 
ATOM   4100 C  CA  . ALA   A 1  505 ? -36.289 -5.912  -29.659 1    31.418  ? 541  ALA   A CA  1 
ATOM   4101 C  C   . ALA   A 1  505 ? -37.323 -6.038  -30.8   1    29.934  ? 541  ALA   A C   1 
ATOM   4102 O  O   . ALA   A 1  505 ? -38.315 -5.329  -30.757 1    34.568  ? 541  ALA   A O   1 
ATOM   4103 C  CB  . ALA   A 1  505 ? -35.795 -4.47   -29.485 1    25.708  ? 541  ALA   A CB  1 
ATOM   4104 N  N   . GLY   A 1  506 ? -37.126 -6.91   -31.799 1    33.032  ? 542  GLY   A N   1 
ATOM   4105 C  CA  . GLY   A 1  506 ? -38.038 -6.964  -32.935 1    29.376  ? 542  GLY   A CA  1 
ATOM   4106 C  C   . GLY   A 1  506 ? -37.873 -5.786  -33.905 1    40.793  ? 542  GLY   A C   1 
ATOM   4107 O  O   . GLY   A 1  506 ? -38.767 -5.573  -34.705 1    36.605  ? 542  GLY   A O   1 
ATOM   4108 N  N   . HIS   A 1  507 ? -36.736 -5.041  -33.921 1    42.344  ? 543  HIS   A N   1 
ATOM   4109 C  CA  . HIS   A 1  507 ? -36.51  -3.987  -34.924 1    32.236  ? 543  HIS   A CA  1 
ATOM   4110 C  C   . HIS   A 1  507 ? -36.373 -4.634  -36.309 1    36.688  ? 543  HIS   A C   1 
ATOM   4111 O  O   . HIS   A 1  507 ? -35.681 -5.637  -36.484 1    29.579  ? 543  HIS   A O   1 
ATOM   4112 C  CB  . HIS   A 1  507 ? -35.203 -3.215  -34.656 1    31.572  ? 543  HIS   A CB  1 
ATOM   4113 C  CG  . HIS   A 1  507 ? -34.857 -2.247  -35.765 1    39.451  ? 543  HIS   A CG  1 
ATOM   4114 N  ND1 . HIS   A 1  507 ? -35.367 -0.951  -35.786 1    38.536  ? 543  HIS   A ND1 1 
ATOM   4115 C  CD2 . HIS   A 1  507 ? -34.072 -2.346  -36.894 1    38.107  ? 543  HIS   A CD2 1 
ATOM   4116 C  CE1 . HIS   A 1  507 ? -34.957 -0.307  -36.897 1    35.79   ? 543  HIS   A CE1 1 
ATOM   4117 N  NE2 . HIS   A 1  507 ? -34.152 -1.112  -37.574 1    31.998  ? 543  HIS   A NE2 1 
ATOM   4118 N  N   . THR   A 1  508 ? -36.978 -4.043  -37.351 1    35.768  ? 544  THR   A N   1 
ATOM   4119 C  CA  . THR   A 1  508 ? -36.636 -4.484  -38.692 1    36.517  ? 544  THR   A CA  1 
ATOM   4120 C  C   . THR   A 1  508 ? -36.225 -3.253  -39.491 1    32.743  ? 544  THR   A C   1 
ATOM   4121 O  O   . THR   A 1  508 ? -36.572 -2.116  -39.129 1    41.308  ? 544  THR   A O   1 
ATOM   4122 C  CB  . THR   A 1  508 ? -37.823 -5.19   -39.37  1    45.37   ? 544  THR   A CB  1 
ATOM   4123 O  OG1 . THR   A 1  508 ? -38.94  -4.322  -39.16  1    50.249  ? 544  THR   A OG1 1 
ATOM   4124 C  CG2 . THR   A 1  508 ? -38.157 -6.533  -38.756 1    43.985  ? 544  THR   A CG2 1 
ATOM   4125 N  N   . GLY   A 1  509 ? -35.625 -3.527  -40.636 1    37.486  ? 545  GLY   A N   1 
ATOM   4126 C  CA  . GLY   A 1  509 ? -35.194 -2.467  -41.535 1    38.123  ? 545  GLY   A CA  1 
ATOM   4127 C  C   . GLY   A 1  509 ? -33.759 -2.113  -41.176 1    39.378  ? 545  GLY   A C   1 
ATOM   4128 O  O   . GLY   A 1  509 ? -33.152 -2.82   -40.393 1    35.677  ? 545  GLY   A O   1 
ATOM   4129 N  N   . PRO   A 1  510 ? -33.178 -0.997  -41.66  1    42.161  ? 546  PRO   A N   1 
ATOM   4130 C  CA  . PRO   A 1  510 ? -31.751 -0.748  -41.441 1    32.488  ? 546  PRO   A CA  1 
ATOM   4131 C  C   . PRO   A 1  510 ? -31.376 -0.647  -39.951 1    26.521  ? 546  PRO   A C   1 
ATOM   4132 O  O   . PRO   A 1  510 ? -32.075 0.002   -39.142 1    24.626  ? 546  PRO   A O   1 
ATOM   4133 C  CB  . PRO   A 1  510 ? -31.554 0.576   -42.201 1    33.427  ? 546  PRO   A CB  1 
ATOM   4134 C  CG  . PRO   A 1  510 ? -32.644 0.499   -43.259 1    41.702  ? 546  PRO   A CG  1 
ATOM   4135 C  CD  . PRO   A 1  510 ? -33.835 0.092   -42.397 1    40.154  ? 546  PRO   A CD  1 
ATOM   4136 N  N   . LEU   A 1  511 ? -30.193 -1.226  -39.656 1    26.615  ? 547  LEU   A N   1 
ATOM   4137 C  CA  . LEU   A 1  511 ? -29.71  -1.291  -38.277 1    26.519  ? 547  LEU   A CA  1 
ATOM   4138 C  C   . LEU   A 1  511 ? -29.573 0.128   -37.7   1    20.714  ? 547  LEU   A C   1 
ATOM   4139 O  O   . LEU   A 1  511 ? -29.917 0.427   -36.544 1    22.157  ? 547  LEU   A O   1 
ATOM   4140 C  CB  . LEU   A 1  511 ? -28.434 -2.14   -38.268 1    21.802  ? 547  LEU   A CB  1 
ATOM   4141 C  CG  . LEU   A 1  511 ? -27.746 -2.174  -36.898 1    20.544  ? 547  LEU   A CG  1 
ATOM   4142 C  CD1 . LEU   A 1  511 ? -28.775 -2.687  -35.827 1    17.757  ? 547  LEU   A CD1 1 
ATOM   4143 C  CD2 . LEU   A 1  511 ? -26.473 -2.991  -36.975 1    18.466  ? 547  LEU   A CD2 1 
ATOM   4144 N  N   . HIS   A 1  512 ? -29.264 1.096   -38.553 1    19.983  ? 548  HIS   A N   1 
ATOM   4145 C  CA  . HIS   A 1  512 ? -28.987 2.424   -38     1    20.347  ? 548  HIS   A CA  1 
ATOM   4146 C  C   . HIS   A 1  512 ? -30.258 3.133   -37.544 1    27.703  ? 548  HIS   A C   1 
ATOM   4147 O  O   . HIS   A 1  512 ? -30.189 4.131   -36.839 1    26.434  ? 548  HIS   A O   1 
ATOM   4148 C  CB  . HIS   A 1  512 ? -28.11  3.224   -38.984 1    21.395  ? 548  HIS   A CB  1 
ATOM   4149 C  CG  . HIS   A 1  512 ? -28.878 3.715   -40.173 1    24.303  ? 548  HIS   A CG  1 
ATOM   4150 N  ND1 . HIS   A 1  512 ? -29.059 2.889   -41.28  1    25.451  ? 548  HIS   A ND1 1 
ATOM   4151 C  CD2 . HIS   A 1  512 ? -29.559 4.892   -40.438 1    22.614  ? 548  HIS   A CD2 1 
ATOM   4152 C  CE1 . HIS   A 1  512 ? -29.731 3.553   -42.234 1    22.709  ? 548  HIS   A CE1 1 
ATOM   4153 N  NE2 . HIS   A 1  512 ? -30.104 4.746   -41.722 1    27.36   ? 548  HIS   A NE2 1 
ATOM   4154 N  N   . LYS   A 1  513 ? -31.453 2.623   -37.929 1    29.223  ? 549  LYS   A N   1 
ATOM   4155 C  CA  . LYS   A 1  513 ? -32.697 3.273   -37.523 1    29.609  ? 549  LYS   A CA  1 
ATOM   4156 C  C   . LYS   A 1  513 ? -33.173 2.642   -36.21  1    32.147  ? 549  LYS   A C   1 
ATOM   4157 O  O   . LYS   A 1  513 ? -34.181 3.065   -35.658 1    29.103  ? 549  LYS   A O   1 
ATOM   4158 C  CB  . LYS   A 1  513 ? -33.727 3.067   -38.651 1    33.091  ? 549  LYS   A CB  1 
ATOM   4159 C  CG  . LYS   A 1  513 ? -33.381 3.928   -39.896 1    43.707  ? 549  LYS   A CG  1 
ATOM   4160 C  CD  . LYS   A 1  513 ? -34.361 3.821   -41.063 1    51.731  ? 549  LYS   A CD  1 
ATOM   4161 C  CE  . LYS   A 1  513 ? -34.35  4.966   -42.026 1    54.003  ? 549  LYS   A CE  1 
ATOM   4162 N  NZ  . LYS   A 1  513 ? -34.325 6.106   -41.106 1    59.164  ? 549  LYS   A NZ  1 
ATOM   4163 N  N   . CYS   A 1  514 ? -32.453 1.616   -35.7   1    25.673  ? 550  CYS   A N   1 
ATOM   4164 C  CA  . CYS   A 1  514 ? -32.953 0.987   -34.48  1    22.662  ? 550  CYS   A CA  1 
ATOM   4165 C  C   . CYS   A 1  514 ? -32.796 1.852   -33.237 1    23.113  ? 550  CYS   A C   1 
ATOM   4166 O  O   . CYS   A 1  514 ? -31.752 2.491   -33.009 1    26.085  ? 550  CYS   A O   1 
ATOM   4167 C  CB  . CYS   A 1  514 ? -32.298 -0.374  -34.278 1    24.328  ? 550  CYS   A CB  1 
ATOM   4168 S  SG  . CYS   A 1  514 ? -32.44  -0.957  -32.581 1    25.657  ? 550  CYS   A SG  1 
ATOM   4169 N  N   . ASP   A 1  515 ? -33.841 1.829   -32.379 1    20.961  ? 551  ASP   A N   1 
ATOM   4170 C  CA  . ASP   A 1  515 ? -33.781 2.489   -31.074 1    21.48   ? 551  ASP   A CA  1 
ATOM   4171 C  C   . ASP   A 1  515 ? -34.341 1.508   -30.04  1    26.537  ? 551  ASP   A C   1 
ATOM   4172 O  O   . ASP   A 1  515 ? -35.496 1.108   -30.159 1    23.428  ? 551  ASP   A O   1 
ATOM   4173 C  CB  . ASP   A 1  515 ? -34.548 3.798   -31.137 1    23.036  ? 551  ASP   A CB  1 
ATOM   4174 C  CG  . ASP   A 1  515 ? -34.807 4.498   -29.816 1    24.778  ? 551  ASP   A CG  1 
ATOM   4175 O  OD1 . ASP   A 1  515 ? -34.342 4.042   -28.755 1    26.474  ? 551  ASP   A OD1 1 
ATOM   4176 O  OD2 . ASP   A 1  515 ? -35.502 5.536   -29.838 1    30.343  ? 551  ASP   A OD2 1 
ATOM   4177 N  N   . ILE   A 1  516 ? -33.537 1.048   -29.057 1    24.159  ? 552  ILE   A N   1 
ATOM   4178 C  CA  . ILE   A 1  516 ? -33.974 -0.042  -28.172 1    21.49   ? 552  ILE   A CA  1 
ATOM   4179 C  C   . ILE   A 1  516 ? -34.642 0.539   -26.918 1    23.395  ? 552  ILE   A C   1 
ATOM   4180 O  O   . ILE   A 1  516 ? -34.945 -0.168  -25.946 1    25.085  ? 552  ILE   A O   1 
ATOM   4181 C  CB  . ILE   A 1  516 ? -32.758 -0.918  -27.769 1    24.81   ? 552  ILE   A CB  1 
ATOM   4182 C  CG1 . ILE   A 1  516 ? -31.783 -0.124  -26.877 1    21.184  ? 552  ILE   A CG1 1 
ATOM   4183 C  CG2 . ILE   A 1  516 ? -32.138 -1.519  -29.037 1    22.96   ? 552  ILE   A CG2 1 
ATOM   4184 C  CD1 . ILE   A 1  516 ? -30.679 -0.943  -26.174 1    18.972  ? 552  ILE   A CD1 1 
ATOM   4185 N  N   . TYR   A 1  517 ? -34.91  1.847   -26.91  1    20.563  ? 553  TYR   A N   1 
ATOM   4186 C  CA  . TYR   A 1  517 ? -35.521 2.422   -25.724 1    22.19   ? 553  TYR   A CA  1 
ATOM   4187 C  C   . TYR   A 1  517 ? -36.748 1.602   -25.332 1    25.12   ? 553  TYR   A C   1 
ATOM   4188 O  O   . TYR   A 1  517 ? -37.572 1.276   -26.179 1    22.135  ? 553  TYR   A O   1 
ATOM   4189 C  CB  . TYR   A 1  517 ? -35.964 3.852   -26.068 1    20.837  ? 553  TYR   A CB  1 
ATOM   4190 C  CG  . TYR   A 1  517 ? -36.54  4.49    -24.815 1    24.906  ? 553  TYR   A CG  1 
ATOM   4191 C  CD1 . TYR   A 1  517 ? -35.717 4.867   -23.761 1    26.035  ? 553  TYR   A CD1 1 
ATOM   4192 C  CD2 . TYR   A 1  517 ? -37.917 4.656   -24.641 1    26.072  ? 553  TYR   A CD2 1 
ATOM   4193 C  CE1 . TYR   A 1  517 ? -36.216 5.515   -22.625 1    26.595  ? 553  TYR   A CE1 1 
ATOM   4194 C  CE2 . TYR   A 1  517 ? -38.431 5.246   -23.496 1    23.747  ? 553  TYR   A CE2 1 
ATOM   4195 C  CZ  . TYR   A 1  517 ? -37.59  5.663   -22.476 1    30.37   ? 553  TYR   A CZ  1 
ATOM   4196 O  OH  . TYR   A 1  517 ? -38.101 6.221   -21.329 1    30.063  ? 553  TYR   A OH  1 
ATOM   4197 N  N   . GLN   A 1  518 ? -36.851 1.297   -24.04  1    26.379  ? 554  GLN   A N   1 
ATOM   4198 C  CA  . GLN   A 1  518 ? -37.943 0.594   -23.371 1    29.149  ? 554  GLN   A CA  1 
ATOM   4199 C  C   . GLN   A 1  518 ? -37.97  -0.897  -23.662 1    30.485  ? 554  GLN   A C   1 
ATOM   4200 O  O   . GLN   A 1  518 ? -38.863 -1.611  -23.208 1    28.592  ? 554  GLN   A O   1 
ATOM   4201 C  CB  . GLN   A 1  518 ? -39.319 1.177   -23.699 1    28.943  ? 554  GLN   A CB  1 
ATOM   4202 C  CG  . GLN   A 1  518 ? -40.241 1.083   -22.497 1    32.01   ? 554  GLN   A CG  1 
ATOM   4203 C  CD  . GLN   A 1  518 ? -41.612 1.659   -22.813 1    34.448  ? 554  GLN   A CD  1 
ATOM   4204 O  OE1 . GLN   A 1  518 ? -41.722 2.839   -23.153 1    26.607  ? 554  GLN   A OE1 1 
ATOM   4205 N  NE2 . GLN   A 1  518 ? -42.65  0.829   -22.73  1    30.058  ? 554  GLN   A NE2 1 
ATOM   4206 N  N   . SER   A 1  519 ? -36.984 -1.407  -24.387 1    25.533  ? 555  SER   A N   1 
ATOM   4207 C  CA  . SER   A 1  519 ? -37.042 -2.819  -24.723 1    23.131  ? 555  SER   A CA  1 
ATOM   4208 C  C   . SER   A 1  519 ? -36.564 -3.732  -23.573 1    31.813  ? 555  SER   A C   1 
ATOM   4209 O  O   . SER   A 1  519 ? -35.366 -3.763  -23.207 1    26.065  ? 555  SER   A O   1 
ATOM   4210 C  CB  . SER   A 1  519 ? -36.214 -3.032  -25.927 1    22.379  ? 555  SER   A CB  1 
ATOM   4211 O  OG  . SER   A 1  519 ? -36.005 -4.43   -26.081 1    21.227  ? 555  SER   A OG  1 
ATOM   4212 N  N   . LYS   A 1  520 ? -37.505 -4.482  -22.964 1    28.271  ? 556  LYS   A N   1 
ATOM   4213 C  CA  . LYS   A 1  520 ? -37.177 -5.34   -21.834 1    27.641  ? 556  LYS   A CA  1 
ATOM   4214 C  C   . LYS   A 1  520 ? -36.383 -6.54   -22.349 1    24.541  ? 556  LYS   A C   1 
ATOM   4215 O  O   . LYS   A 1  520 ? -35.525 -7.05   -21.624 1    24.122  ? 556  LYS   A O   1 
ATOM   4216 C  CB  . LYS   A 1  520 ? -38.435 -5.644  -21.019 1    31.415  ? 556  LYS   A CB  1 
ATOM   4217 C  CG  . LYS   A 1  520 ? -39.213 -4.419  -20.462 1    30.137  ? 556  LYS   A CG  1 
ATOM   4218 C  CD  . LYS   A 1  520 ? -38.518 -3.492  -19.465 1    28.859  ? 556  LYS   A CD  1 
ATOM   4219 C  CE  . LYS   A 1  520 ? -39.47  -2.449  -18.907 1    23.552  ? 556  LYS   A CE  1 
ATOM   4220 N  NZ  . LYS   A 1  520 ? -39.723 -1.515  -19.981 1    22.387  ? 556  LYS   A NZ  1 
ATOM   4221 N  N   . GLU   A 1  521 ? -36.564 -6.886  -23.638 1    23.498  ? 557  GLU   A N   1 
ATOM   4222 C  CA  . GLU   A 1  521 ? -35.829 -7.993  -24.217 1    27.361  ? 557  GLU   A CA  1 
ATOM   4223 C  C   . GLU   A 1  521 ? -34.352 -7.585  -24.311 1    34.232  ? 557  GLU   A C   1 
ATOM   4224 O  O   . GLU   A 1  521 ? -33.442 -8.386  -24.015 1    26.849  ? 557  GLU   A O   1 
ATOM   4225 C  CB  . GLU   A 1  521 ? -36.413 -8.584  -25.514 1    30.371  ? 557  GLU   A CB  1 
ATOM   4226 C  CG  . GLU   A 1  521 ? -37.827 -9.177  -25.371 1    35.573  ? 557  GLU   A CG  1 
ATOM   4227 C  CD  . GLU   A 1  521 ? -38.986 -8.224  -25.023 1    50.114  ? 557  GLU   A CD  1 
ATOM   4228 O  OE1 . GLU   A 1  521 ? -38.942 -6.954  -25.19  1    39.382  ? 557  GLU   A OE1 1 
ATOM   4229 O  OE2 . GLU   A 1  521 ? -39.973 -8.795  -24.489 1    53.254  ? 557  GLU   A OE2 1 
ATOM   4230 N  N   . ALA   A 1  522 ? -34.107 -6.314  -24.694 1    32.005  ? 558  ALA   A N   1 
ATOM   4231 C  CA  . ALA   A 1  522 ? -32.706 -5.916  -24.882 1    29.866  ? 558  ALA   A CA  1 
ATOM   4232 C  C   . ALA   A 1  522 ? -32.067 -5.884  -23.498 1    26.887  ? 558  ALA   A C   1 
ATOM   4233 O  O   . ALA   A 1  522 ? -30.961 -6.417  -23.285 1    27.573  ? 558  ALA   A O   1 
ATOM   4234 C  CB  . ALA   A 1  522 ? -32.57  -4.588  -25.625 1    22.672  ? 558  ALA   A CB  1 
ATOM   4235 N  N   . GLY   A 1  523 ? -32.777 -5.267  -22.56  1    20.327  ? 559  GLY   A N   1 
ATOM   4236 C  CA  . GLY   A 1  523 ? -32.276 -5.197  -21.195 1    20.395  ? 559  GLY   A CA  1 
ATOM   4237 C  C   . GLY   A 1  523 ? -31.881 -6.578  -20.648 1    26.316  ? 559  GLY   A C   1 
ATOM   4238 O  O   . GLY   A 1  523 ? -30.863 -6.72   -19.98  1    28.242  ? 559  GLY   A O   1 
ATOM   4239 N  N   . GLN   A 1  524 ? -32.716 -7.612  -20.85  1    28.91   ? 560  GLN   A N   1 
ATOM   4240 C  CA  . GLN   A 1  524 ? -32.421 -8.883  -20.194 1    30.329  ? 560  GLN   A CA  1 
ATOM   4241 C  C   . GLN   A 1  524 ? -31.135 -9.499  -20.751 1    30.306  ? 560  GLN   A C   1 
ATOM   4242 O  O   . GLN   A 1  524 ? -30.376 -10.13  -19.986 1    22.793  ? 560  GLN   A O   1 
ATOM   4243 C  CB  . GLN   A 1  524 ? -33.47  -9.994  -20.308 1    42.551  ? 560  GLN   A CB  1 
ATOM   4244 C  CG  . GLN   A 1  524 ? -34.421 -10.098 -19.121 1    79.593  ? 560  GLN   A CG  1 
ATOM   4245 C  CD  . GLN   A 1  524 ? -35.818 -10.532 -19.532 1    115.464 ? 560  GLN   A CD  1 
ATOM   4246 O  OE1 . GLN   A 1  524 ? -36.193 -10.517 -20.717 1    125.908 ? 560  GLN   A OE1 1 
ATOM   4247 N  NE2 . GLN   A 1  524 ? -36.619 -10.908 -18.543 1    117.773 ? 560  GLN   A NE2 1 
ATOM   4248 N  N   . ARG   A 1  525 ? -30.964 -9.402  -22.075 1    24.21   ? 561  ARG   A N   1 
ATOM   4249 C  CA  . ARG   A 1  525 ? -29.721 -9.848  -22.681 1    32.288  ? 561  ARG   A CA  1 
ATOM   4250 C  C   . ARG   A 1  525 ? -28.519 -9.182  -22.003 1    36.847  ? 561  ARG   A C   1 
ATOM   4251 O  O   . ARG   A 1  525 ? -27.525 -9.861  -21.712 1    32.68   ? 561  ARG   A O   1 
ATOM   4252 C  CB  . ARG   A 1  525 ? -29.52  -9.458  -24.137 1    33.489  ? 561  ARG   A CB  1 
ATOM   4253 C  CG  . ARG   A 1  525 ? -30.464 -10.011 -25.178 1    34.493  ? 561  ARG   A CG  1 
ATOM   4254 C  CD  . ARG   A 1  525 ? -29.983 -11.385 -25.442 1    35.295  ? 561  ARG   A CD  1 
ATOM   4255 N  NE  . ARG   A 1  525 ? -31.105 -11.699 -26.321 1    30.372  ? 561  ARG   A NE  1 
ATOM   4256 C  CZ  . ARG   A 1  525 ? -31.027 -11.797 -27.626 1    34.647  ? 561  ARG   A CZ  1 
ATOM   4257 N  NH1 . ARG   A 1  525 ? -29.885 -11.654 -28.252 1    35.43   ? 561  ARG   A NH1 1 
ATOM   4258 N  NH2 . ARG   A 1  525 ? -32.109 -12.134 -28.294 1    40.937  ? 561  ARG   A NH2 1 
ATOM   4259 N  N   . LEU   A 1  526 ? -28.584 -7.849  -21.809 1    24.704  ? 562  LEU   A N   1 
ATOM   4260 C  CA  . LEU   A 1  526 ? -27.439 -7.122  -21.268 1    25.48   ? 562  LEU   A CA  1 
ATOM   4261 C  C   . LEU   A 1  526 ? -27.218 -7.541  -19.813 1    27.155  ? 562  LEU   A C   1 
ATOM   4262 O  O   . LEU   A 1  526 ? -26.064 -7.641  -19.376 1    24.149  ? 562  LEU   A O   1 
ATOM   4263 C  CB  . LEU   A 1  526 ? -27.643 -5.595  -21.294 1    24.104  ? 562  LEU   A CB  1 
ATOM   4264 C  CG  . LEU   A 1  526 ? -27.456 -4.923  -22.648 1    30.68   ? 562  LEU   A CG  1 
ATOM   4265 C  CD1 . LEU   A 1  526 ? -27.656 -3.397  -22.534 1    25.555  ? 562  LEU   A CD1 1 
ATOM   4266 C  CD2 . LEU   A 1  526 ? -26.077 -5.357  -23.27  1    30.373  ? 562  LEU   A CD2 1 
ATOM   4267 N  N   . ALA   A 1  527 ? -28.32  -7.642  -19.051 1    21.245  ? 563  ALA   A N   1 
ATOM   4268 C  CA  . ALA   A 1  527 ? -28.231 -7.909  -17.608 1    24.891  ? 563  ALA   A CA  1 
ATOM   4269 C  C   . ALA   A 1  527 ? -27.595 -9.282  -17.36  1    26.623  ? 563  ALA   A C   1 
ATOM   4270 O  O   . ALA   A 1  527 ? -26.799 -9.441  -16.444 1    25.576  ? 563  ALA   A O   1 
ATOM   4271 C  CB  . ALA   A 1  527 ? -29.601 -7.872  -16.989 1    25.394  ? 563  ALA   A CB  1 
ATOM   4272 N  N   . THR   A 1  528 ? -27.932 -10.269 -18.194 1    25.949  ? 564  THR   A N   1 
ATOM   4273 C  CA  . THR   A 1  528 ? -27.452 -11.597 -17.876 1    24.288  ? 564  THR   A CA  1 
ATOM   4274 C  C   . THR   A 1  528 ? -25.959 -11.652 -18.147 1    27.176  ? 564  THR   A C   1 
ATOM   4275 O  O   . THR   A 1  528 ? -25.229 -12.344 -17.409 1    25.981  ? 564  THR   A O   1 
ATOM   4276 C  CB  . THR   A 1  528 ? -28.278 -12.726 -18.507 1    33.522  ? 564  THR   A CB  1 
ATOM   4277 O  OG1 . THR   A 1  528 ? -27.951 -12.926 -19.868 1    48.366  ? 564  THR   A OG1 1 
ATOM   4278 C  CG2 . THR   A 1  528 ? -29.773 -12.51  -18.387 1    29.313  ? 564  THR   A CG2 1 
ATOM   4279 N  N   . ALA   A 1  529 ? -25.517 -10.97  -19.229 1    22.862  ? 565  ALA   A N   1 
ATOM   4280 C  CA  . ALA   A 1  529 ? -24.099 -10.844 -19.555 1    21.917  ? 565  ALA   A CA  1 
ATOM   4281 C  C   . ALA   A 1  529 ? -23.35  -10.118 -18.444 1    22.753  ? 565  ALA   A C   1 
ATOM   4282 O  O   . ALA   A 1  529 ? -22.263 -10.569 -18.024 1    27.817  ? 565  ALA   A O   1 
ATOM   4283 C  CB  . ALA   A 1  529 ? -23.918 -10.165 -20.91  1    19.94   ? 565  ALA   A CB  1 
ATOM   4284 N  N   . MET   A 1  530 ? -23.895 -8.971  -17.987 1    19.82   ? 566  MET   A N   1 
ATOM   4285 C  CA  . MET   A 1  530 ? -23.136 -8.202  -17.027 1    21.513  ? 566  MET   A CA  1 
ATOM   4286 C  C   . MET   A 1  530 ? -23.002 -8.957  -15.703 1    27.898  ? 566  MET   A C   1 
ATOM   4287 O  O   . MET   A 1  530 ? -22.028 -8.753  -14.975 1    25.936  ? 566  MET   A O   1 
ATOM   4288 C  CB  . MET   A 1  530 ? -23.858 -6.887  -16.733 1    21.273  ? 566  MET   A CB  1 
ATOM   4289 C  CG  . MET   A 1  530 ? -23.625 -5.828  -17.857 1    21.357  ? 566  MET   A CG  1 
ATOM   4290 S  SD  . MET   A 1  530 ? -24.289 -4.177  -17.506 1    25.153  ? 566  MET   A SD  1 
ATOM   4291 C  CE  . MET   A 1  530 ? -25.868 -4.596  -18.235 1    26.525  ? 566  MET   A CE  1 
ATOM   4292 N  N   . LYS   A 1  531 ? -24.067 -9.667  -15.314 1    26.908  ? 567  LYS   A N   1 
ATOM   4293 C  CA  . LYS   A 1  531 ? -24.093 -10.439 -14.073 1    26.04   ? 567  LYS   A CA  1 
ATOM   4294 C  C   . LYS   A 1  531 ? -22.963 -11.461 -14.001 1    21.991  ? 567  LYS   A C   1 
ATOM   4295 O  O   . LYS   A 1  531 ? -22.546 -11.751 -12.908 1    23.958  ? 567  LYS   A O   1 
ATOM   4296 C  CB  . LYS   A 1  531 ? -25.427 -11.181 -13.861 1    26.513  ? 567  LYS   A CB  1 
ATOM   4297 C  CG  . LYS   A 1  531 ? -26.493 -10.282 -13.202 1    36.847  ? 567  LYS   A CG  1 
ATOM   4298 C  CD  . LYS   A 1  531 ? -27.847 -10.994 -13.084 1    41.556  ? 567  LYS   A CD  1 
ATOM   4299 C  CE  . LYS   A 1  531 ? -28.687 -10.294 -12.041 1    51.061  ? 567  LYS   A CE  1 
ATOM   4300 N  NZ  . LYS   A 1  531 ? -28.684 -8.873  -12.363 1    50.382  ? 567  LYS   A NZ  1 
ATOM   4301 N  N   . LEU   A 1  532 ? -22.417 -11.931 -15.144 1    21.665  ? 568  LEU   A N   1 
ATOM   4302 C  CA  . LEU   A 1  532 ? -21.261 -12.809 -15.233 1    25.268  ? 568  LEU   A CA  1 
ATOM   4303 C  C   . LEU   A 1  532 ? -19.995 -12.163 -14.66  1    26.606  ? 568  LEU   A C   1 
ATOM   4304 O  O   . LEU   A 1  532 ? -19.095 -12.91  -14.257 1    21.333  ? 568  LEU   A O   1 
ATOM   4305 C  CB  . LEU   A 1  532 ? -21.008 -13.32  -16.654 1    26.8    ? 568  LEU   A CB  1 
ATOM   4306 C  CG  . LEU   A 1  532 ? -22.071 -14.305 -17.179 1    35.686  ? 568  LEU   A CG  1 
ATOM   4307 C  CD1 . LEU   A 1  532 ? -21.69  -14.818 -18.569 1    30.667  ? 568  LEU   A CD1 1 
ATOM   4308 C  CD2 . LEU   A 1  532 ? -22.366 -15.427 -16.19  1    33.114  ? 568  LEU   A CD2 1 
ATOM   4309 N  N   . GLY   A 1  533 ? -19.953 -10.812 -14.599 1    23.148  ? 569  GLY   A N   1 
ATOM   4310 C  CA  . GLY   A 1  533 ? -18.692 -10.099 -14.343 1    23.205  ? 569  GLY   A CA  1 
ATOM   4311 C  C   . GLY   A 1  533 ? -17.528 -10.736 -15.111 1    23.241  ? 569  GLY   A C   1 
ATOM   4312 O  O   . GLY   A 1  533 ? -17.62  -10.98  -16.31  1    20.107  ? 569  GLY   A O   1 
ATOM   4313 N  N   . PHE   A 1  534 ? -16.457 -11.095 -14.367 1    20.669  ? 570  PHE   A N   1 
ATOM   4314 C  CA  . PHE   A 1  534 ? -15.293 -11.741 -14.948 1    22.406  ? 570  PHE   A CA  1 
ATOM   4315 C  C   . PHE   A 1  534 ? -15.283 -13.218 -14.529 1    23.82   ? 570  PHE   A C   1 
ATOM   4316 O  O   . PHE   A 1  534 ? -14.233 -13.84  -14.574 1    28.794  ? 570  PHE   A O   1 
ATOM   4317 C  CB  . PHE   A 1  534 ? -14.011 -11.012 -14.482 1    21.482  ? 570  PHE   A CB  1 
ATOM   4318 C  CG  . PHE   A 1  534 ? -12.665 -11.304 -15.151 1    26.721  ? 570  PHE   A CG  1 
ATOM   4319 C  CD1 . PHE   A 1  534 ? -12.458 -11.012 -16.505 1    28.632  ? 570  PHE   A CD1 1 
ATOM   4320 C  CD2 . PHE   A 1  534 ? -11.561 -11.779 -14.439 1    29.737  ? 570  PHE   A CD2 1 
ATOM   4321 C  CE1 . PHE   A 1  534 ? -11.249 -11.285 -17.143 1    27.828  ? 570  PHE   A CE1 1 
ATOM   4322 C  CE2 . PHE   A 1  534 ? -10.305 -11.976 -15.057 1    27.679  ? 570  PHE   A CE2 1 
ATOM   4323 C  CZ  . PHE   A 1  534 ? -10.145 -11.725 -16.412 1    29.371  ? 570  PHE   A CZ  1 
ATOM   4324 N  N   . SER   A 1  535 ? -16.441 -13.786 -14.22  1    23.401  ? 571  SER   A N   1 
ATOM   4325 C  CA  . SER   A 1  535 ? -16.517 -15.174 -13.761 1    23.463  ? 571  SER   A CA  1 
ATOM   4326 C  C   . SER   A 1  535 ? -16.231 -16.166 -14.875 1    27.475  ? 571  SER   A C   1 
ATOM   4327 O  O   . SER   A 1  535 ? -15.783 -17.272 -14.548 1    23.452  ? 571  SER   A O   1 
ATOM   4328 C  CB  . SER   A 1  535 ? -17.891 -15.479 -13.137 1    24.517  ? 571  SER   A CB  1 
ATOM   4329 O  OG  . SER   A 1  535 ? -18.871 -15.444 -14.151 1    26.009  ? 571  SER   A OG  1 
ATOM   4330 N  N   . ARG   A 1  536 ? -16.463 -15.829 -16.171 1    24.216  ? 572  ARG   A N   1 
ATOM   4331 C  CA  . ARG   A 1  536 ? -16.146 -16.839 -17.206 1    26.61   ? 572  ARG   A CA  1 
ATOM   4332 C  C   . ARG   A 1  536 ? -15.396 -16.215 -18.38  1    27.71   ? 572  ARG   A C   1 
ATOM   4333 O  O   . ARG   A 1  536 ? -15.549 -15.037 -18.561 1    29.535  ? 572  ARG   A O   1 
ATOM   4334 C  CB  . ARG   A 1  536 ? -17.44  -17.277 -17.887 1    29.702  ? 572  ARG   A CB  1 
ATOM   4335 C  CG  . ARG   A 1  536 ? -18.602 -17.64  -16.972 1    39.684  ? 572  ARG   A CG  1 
ATOM   4336 C  CD  . ARG   A 1  536 ? -18.51  -18.994 -16.258 1    45.828  ? 572  ARG   A CD  1 
ATOM   4337 N  NE  . ARG   A 1  536 ? -18.414 -20.071 -17.245 1    72.979  ? 572  ARG   A NE  1 
ATOM   4338 C  CZ  . ARG   A 1  536 ? -17.46  -21.002 -17.295 1    66.791  ? 572  ARG   A CZ  1 
ATOM   4339 N  NH1 . ARG   A 1  536 ? -17.271 -21.721 -18.383 1    47.723  ? 572  ARG   A NH1 1 
ATOM   4340 N  NH2 . ARG   A 1  536 ? -16.638 -21.149 -16.276 1    80.308  ? 572  ARG   A NH2 1 
ATOM   4341 N  N   . PRO   A 1  537 ? -14.677 -16.947 -19.27  1    32.087  ? 573  PRO   A N   1 
ATOM   4342 C  CA  . PRO   A 1  537 ? -14.064 -16.34  -20.458 1    31.191  ? 573  PRO   A CA  1 
ATOM   4343 C  C   . PRO   A 1  537 ? -15.086 -15.434 -21.182 1    27.583  ? 573  PRO   A C   1 
ATOM   4344 O  O   . PRO   A 1  537 ? -16.283 -15.795 -21.298 1    23.079  ? 573  PRO   A O   1 
ATOM   4345 C  CB  . PRO   A 1  537 ? -13.705 -17.609 -21.314 1    36.454  ? 573  PRO   A CB  1 
ATOM   4346 C  CG  . PRO   A 1  537 ? -13.594 -18.786 -20.346 1    35.937  ? 573  PRO   A CG  1 
ATOM   4347 C  CD  . PRO   A 1  537 ? -14.519 -18.419 -19.224 1    38.447  ? 573  PRO   A CD  1 
ATOM   4348 N  N   . TRP   A 1  538 ? -14.625 -14.306 -21.77  1    20.454  ? 574  TRP   A N   1 
ATOM   4349 C  CA  . TRP   A 1  538 ? -15.544 -13.331 -22.363 1    21.553  ? 574  TRP   A CA  1 
ATOM   4350 C  C   . TRP   A 1  538 ? -16.368 -13.905 -23.549 1    22.655  ? 574  TRP   A C   1 
ATOM   4351 O  O   . TRP   A 1  538 ? -17.473 -13.408 -23.787 1    19.599  ? 574  TRP   A O   1 
ATOM   4352 C  CB  . TRP   A 1  538 ? -14.792 -12.048 -22.734 1    17.754  ? 574  TRP   A CB  1 
ATOM   4353 C  CG  . TRP   A 1  538 ? -13.82  -12.226 -23.888 1    18.35   ? 574  TRP   A CG  1 
ATOM   4354 C  CD1 . TRP   A 1  538 ? -12.461 -12.338 -23.798 1    17.832  ? 574  TRP   A CD1 1 
ATOM   4355 C  CD2 . TRP   A 1  538 ? -14.127 -12.27  -25.297 1    18.287  ? 574  TRP   A CD2 1 
ATOM   4356 N  NE1 . TRP   A 1  538 ? -11.896 -12.415 -25.052 1    20.329  ? 574  TRP   A NE1 1 
ATOM   4357 C  CE2 . TRP   A 1  538 ? -12.909 -12.425 -25.98  1    19.525  ? 574  TRP   A CE2 1 
ATOM   4358 C  CE3 . TRP   A 1  538 ? -15.336 -12.234 -26.025 1    21.814  ? 574  TRP   A CE3 1 
ATOM   4359 C  CZ2 . TRP   A 1  538 ? -12.826 -12.477 -27.368 1    20.084  ? 574  TRP   A CZ2 1 
ATOM   4360 C  CZ3 . TRP   A 1  538 ? -15.265 -12.3   -27.396 1    25.516  ? 574  TRP   A CZ3 1 
ATOM   4361 C  CH2 . TRP   A 1  538 ? -14.032 -12.436 -28.06  1    21.078  ? 574  TRP   A CH2 1 
ATOM   4362 N  N   . PRO   A 1  539 ? -15.917 -14.924 -24.34  1    22.277  ? 575  PRO   A N   1 
ATOM   4363 C  CA  . PRO   A 1  539 ? -16.788 -15.522 -25.366 1    24.227  ? 575  PRO   A CA  1 
ATOM   4364 C  C   . PRO   A 1  539 ? -18.199 -15.907 -24.918 1    22.755  ? 575  PRO   A C   1 
ATOM   4365 O  O   . PRO   A 1  539 ? -19.136 -15.79  -25.699 1    24.802  ? 575  PRO   A O   1 
ATOM   4366 C  CB  . PRO   A 1  539 ? -15.959 -16.709 -25.905 1    19.802  ? 575  PRO   A CB  1 
ATOM   4367 C  CG  . PRO   A 1  539 ? -14.546 -16.155 -25.73  1    26.453  ? 575  PRO   A CG  1 
ATOM   4368 C  CD  . PRO   A 1  539 ? -14.569 -15.535 -24.355 1    20.647  ? 575  PRO   A CD  1 
ATOM   4369 N  N   . GLU   A 1  540 ? -18.357 -16.388 -23.664 1    22.702  ? 576  GLU   A N   1 
ATOM   4370 C  CA  . GLU   A 1  540 ? -19.662 -16.767 -23.145 1    24.797  ? 576  GLU   A CA  1 
ATOM   4371 C  C   . GLU   A 1  540 ? -20.526 -15.534 -23.024 1    26.367  ? 576  GLU   A C   1 
ATOM   4372 O  O   . GLU   A 1  540 ? -21.659 -15.579 -23.469 1    25.766  ? 576  GLU   A O   1 
ATOM   4373 C  CB  . GLU   A 1  540 ? -19.557 -17.416 -21.769 1    29.232  ? 576  GLU   A CB  1 
ATOM   4374 C  CG  . GLU   A 1  540 ? -18.835 -18.754 -21.941 1    36.752  ? 576  GLU   A CG  1 
ATOM   4375 C  CD  . GLU   A 1  540 ? -18.847 -19.62  -20.703 1    41.669  ? 576  GLU   A CD  1 
ATOM   4376 O  OE1 . GLU   A 1  540 ? -19.729 -19.414 -19.796 1    40.203  ? 576  GLU   A OE1 1 
ATOM   4377 O  OE2 . GLU   A 1  540 ? -17.921 -20.487 -20.689 1    42.797  ? 576  GLU   A OE2 1 
ATOM   4378 N  N   . ALA   A 1  541 ? -19.962 -14.441 -22.46  1    22.058  ? 577  ALA   A N   1 
ATOM   4379 C  CA  . ALA   A 1  541 ? -20.774 -13.228 -22.427 1    22.129  ? 577  ALA   A CA  1 
ATOM   4380 C  C   . ALA   A 1  541 ? -21.064 -12.743 -23.861 1    23.724  ? 577  ALA   A C   1 
ATOM   4381 O  O   . ALA   A 1  541 ? -22.194 -12.367 -24.159 1    25.227  ? 577  ALA   A O   1 
ATOM   4382 C  CB  . ALA   A 1  541 ? -20.116 -12.187 -21.562 1    20.774  ? 577  ALA   A CB  1 
ATOM   4383 N  N   . MET   A 1  542 ? -20.085 -12.813 -24.776 1    20.492  ? 578  MET   A N   1 
ATOM   4384 C  CA  . MET   A 1  542 ? -20.349 -12.487 -26.18  1    22.823  ? 578  MET   A CA  1 
ATOM   4385 C  C   . MET   A 1  542 ? -21.507 -13.356 -26.717 1    27.194  ? 578  MET   A C   1 
ATOM   4386 O  O   . MET   A 1  542 ? -22.423 -12.813 -27.358 1    21.981  ? 578  MET   A O   1 
ATOM   4387 C  CB  . MET   A 1  542 ? -19.1   -12.636 -27.059 1    21.248  ? 578  MET   A CB  1 
ATOM   4388 C  CG  . MET   A 1  542 ? -19.321 -12.359 -28.574 1    21.352  ? 578  MET   A CG  1 
ATOM   4389 S  SD  . MET   A 1  542 ? -19.832 -10.646 -28.902 1    23.336  ? 578  MET   A SD  1 
ATOM   4390 C  CE  . MET   A 1  542 ? -18.27  -9.748  -28.709 1    19.405  ? 578  MET   A CE  1 
ATOM   4391 N  N   . GLN   A 1  543 ? -21.473 -14.692 -26.43  1    22.21   ? 579  GLN   A N   1 
ATOM   4392 C  CA  . GLN   A 1  543 ? -22.484 -15.598 -26.985 1    26.877  ? 579  GLN   A CA  1 
ATOM   4393 C  C   . GLN   A 1  543 ? -23.854 -15.309 -26.356 1    25.753  ? 579  GLN   A C   1 
ATOM   4394 O  O   . GLN   A 1  543 ? -24.866 -15.362 -27.053 1    26.393  ? 579  GLN   A O   1 
ATOM   4395 C  CB  . GLN   A 1  543 ? -22.152 -17.099 -26.873 1    25.859  ? 579  GLN   A CB  1 
ATOM   4396 C  CG  . GLN   A 1  543 ? -22.892 -17.96  -27.912 1    29.298  ? 579  GLN   A CG  1 
ATOM   4397 C  CD  . GLN   A 1  543 ? -22.082 -19.193 -28.229 1    36.057  ? 579  GLN   A CD  1 
ATOM   4398 O  OE1 . GLN   A 1  543 ? -20.883 -19.092 -28.455 1    45.953  ? 579  GLN   A OE1 1 
ATOM   4399 N  NE2 . GLN   A 1  543 ? -22.676 -20.378 -28.153 1    46.822  ? 579  GLN   A NE2 1 
ATOM   4400 N  N   . LEU   A 1  544 ? -23.889 -15     -25.043 1    25.057  ? 580  LEU   A N   1 
ATOM   4401 C  CA  . LEU   A 1  544 ? -25.158 -14.65  -24.408 1    26.824  ? 580  LEU   A CA  1 
ATOM   4402 C  C   . LEU   A 1  544 ? -25.819 -13.439 -25.088 1    26.995  ? 580  LEU   A C   1 
ATOM   4403 O  O   . LEU   A 1  544 ? -27.039 -13.362 -25.126 1    26.569  ? 580  LEU   A O   1 
ATOM   4404 C  CB  . LEU   A 1  544 ? -24.948 -14.29  -22.93  1    26.285  ? 580  LEU   A CB  1 
ATOM   4405 C  CG  . LEU   A 1  544 ? -24.816 -15.475 -21.975 1    32.457  ? 580  LEU   A CG  1 
ATOM   4406 C  CD1 . LEU   A 1  544 ? -24.423 -14.998 -20.597 1    32.518  ? 580  LEU   A CD1 1 
ATOM   4407 C  CD2 . LEU   A 1  544 ? -26.146 -16.276 -21.924 1    32.739  ? 580  LEU   A CD2 1 
ATOM   4408 N  N   . ILE   A 1  545 ? -25.055 -12.392 -25.431 1    22.229  ? 581  ILE   A N   1 
ATOM   4409 C  CA  . ILE   A 1  545 ? -25.679 -11.208 -25.992 1    23.44   ? 581  ILE   A CA  1 
ATOM   4410 C  C   . ILE   A 1  545 ? -26.024 -11.471 -27.473 1    22.553  ? 581  ILE   A C   1 
ATOM   4411 O  O   . ILE   A 1  545 ? -27.147 -11.15  -27.889 1    26.412  ? 581  ILE   A O   1 
ATOM   4412 C  CB  . ILE   A 1  545 ? -24.78  -9.959  -25.825 1    23.527  ? 581  ILE   A CB  1 
ATOM   4413 C  CG1 . ILE   A 1  545 ? -24.542 -9.577  -24.354 1    24.82   ? 581  ILE   A CG1 1 
ATOM   4414 C  CG2 . ILE   A 1  545 ? -25.395 -8.757  -26.553 1    22.195  ? 581  ILE   A CG2 1 
ATOM   4415 C  CD1 . ILE   A 1  545 ? -23.268 -8.745  -24.203 1    19.404  ? 581  ILE   A CD1 1 
ATOM   4416 N  N   . THR   A 1  546 ? -25.085 -12.045 -28.243 1    19.847  ? 582  THR   A N   1 
ATOM   4417 C  CA  . THR   A 1  546 ? -25.142 -11.984 -29.699 1    22.764  ? 582  THR   A CA  1 
ATOM   4418 C  C   . THR   A 1  546 ? -25.479 -13.344 -30.337 1    27.532  ? 582  THR   A C   1 
ATOM   4419 O  O   . THR   A 1  546 ? -25.555 -13.417 -31.567 1    24.513  ? 582  THR   A O   1 
ATOM   4420 C  CB  . THR   A 1  546 ? -23.823 -11.46  -30.295 1    21.993  ? 582  THR   A CB  1 
ATOM   4421 O  OG1 . THR   A 1  546 ? -22.85  -12.506 -30.176 1    24.335  ? 582  THR   A OG1 1 
ATOM   4422 C  CG2 . THR   A 1  546 ? -23.372 -10.092 -29.79  1    18.791  ? 582  THR   A CG2 1 
ATOM   4423 N  N   . GLY   A 1  547 ? -25.551 -14.45  -29.572 1    24.691  ? 583  GLY   A N   1 
ATOM   4424 C  CA  . GLY   A 1  547 ? -25.694 -15.756 -30.217 1    25.557  ? 583  GLY   A CA  1 
ATOM   4425 C  C   . GLY   A 1  547 ? -24.443 -16.321 -30.889 1    31.532  ? 583  GLY   A C   1 
ATOM   4426 O  O   . GLY   A 1  547 ? -24.496 -17.404 -31.476 1    27.579  ? 583  GLY   A O   1 
ATOM   4427 N  N   . GLN   A 1  548 ? -23.291 -15.637 -30.812 1    24.339  ? 584  GLN   A N   1 
ATOM   4428 C  CA  . GLN   A 1  548 ? -22.082 -16.253 -31.323 1    23.514  ? 584  GLN   A CA  1 
ATOM   4429 C  C   . GLN   A 1  548 ? -20.927 -15.73  -30.452 1    25.057  ? 584  GLN   A C   1 
ATOM   4430 O  O   . GLN   A 1  548 ? -21.193 -14.844 -29.622 1    21.916  ? 584  GLN   A O   1 
ATOM   4431 C  CB  . GLN   A 1  548 ? -21.94  -15.915 -32.819 1    22.945  ? 584  GLN   A CB  1 
ATOM   4432 C  CG  . GLN   A 1  548 ? -21.921 -14.397 -33.058 1    22.663  ? 584  GLN   A CG  1 
ATOM   4433 C  CD  . GLN   A 1  548 ? -20.535 -13.824 -32.79  1    24.677  ? 584  GLN   A CD  1 
ATOM   4434 O  OE1 . GLN   A 1  548 ? -19.552 -14.371 -33.293 1    23.065  ? 584  GLN   A OE1 1 
ATOM   4435 N  NE2 . GLN   A 1  548 ? -20.41  -12.776 -31.975 1    19.214  ? 584  GLN   A NE2 1 
ATOM   4436 N  N   . PRO   A 1  549 ? -19.71  -16.34  -30.495 1    23.382  ? 585  PRO   A N   1 
ATOM   4437 C  CA  . PRO   A 1  549 ? -18.661 -16.012 -29.508 1    25.067  ? 585  PRO   A CA  1 
ATOM   4438 C  C   . PRO   A 1  549 ? -17.537 -15.071 -29.925 1    21.433  ? 585  PRO   A C   1 
ATOM   4439 O  O   . PRO   A 1  549 ? -16.596 -14.867 -29.171 1    22.927  ? 585  PRO   A O   1 
ATOM   4440 C  CB  . PRO   A 1  549 ? -18.064 -17.486 -29.263 1    21.04   ? 585  PRO   A CB  1 
ATOM   4441 C  CG  . PRO   A 1  549 ? -18.058 -18.184 -30.693 1    20.606  ? 585  PRO   A CG  1 
ATOM   4442 C  CD  . PRO   A 1  549 ? -19.283 -17.459 -31.384 1    23.343  ? 585  PRO   A CD  1 
ATOM   4443 N  N   . GLN   A 1  550 ? -17.501 -14.637 -31.179 1    18.688  ? 586  GLN   A N   1 
ATOM   4444 C  CA  . GLN   A 1  550 ? -16.354 -13.904 -31.682 1    19.909  ? 586  GLN   A CA  1 
ATOM   4445 C  C   . GLN   A 1  550 ? -16.632 -12.389 -31.664 1    19.322  ? 586  GLN   A C   1 
ATOM   4446 O  O   . GLN   A 1  550 ? -17.773 -11.971 -31.689 1    22.617  ? 586  GLN   A O   1 
ATOM   4447 C  CB  . GLN   A 1  550 ? -16.114 -14.291 -33.136 1    28.08   ? 586  GLN   A CB  1 
ATOM   4448 C  CG  . GLN   A 1  550 ? -15.502 -15.674 -33.282 1    36.09   ? 586  GLN   A CG  1 
ATOM   4449 C  CD  . GLN   A 1  550 ? -15.602 -16.107 -34.722 1    63.09   ? 586  GLN   A CD  1 
ATOM   4450 O  OE1 . GLN   A 1  550 ? -14.961 -15.536 -35.616 1    81.519  ? 586  GLN   A OE1 1 
ATOM   4451 N  NE2 . GLN   A 1  550 ? -16.466 -17.085 -34.96  1    76.369  ? 586  GLN   A NE2 1 
ATOM   4452 N  N   . MET   A 1  551 ? -15.563 -11.586 -31.746 1    21.259  ? 587  MET   A N   1 
ATOM   4453 C  CA  . MET   A 1  551 ? -15.681 -10.189 -32.082 1    19.419  ? 587  MET   A CA  1 
ATOM   4454 C  C   . MET   A 1  551 ? -15.777 -10.155 -33.603 1    22.546  ? 587  MET   A C   1 
ATOM   4455 O  O   . MET   A 1  551 ? -15.228 -11.026 -34.279 1    22.608  ? 587  MET   A O   1 
ATOM   4456 C  CB  . MET   A 1  551 ? -14.406 -9.43   -31.668 1    24.257  ? 587  MET   A CB  1 
ATOM   4457 C  CG  . MET   A 1  551 ? -14.205 -9.231  -30.173 1    21.131  ? 587  MET   A CG  1 
ATOM   4458 S  SD  . MET   A 1  551 ? -12.686 -8.337  -29.768 1    25.009  ? 587  MET   A SD  1 
ATOM   4459 C  CE  . MET   A 1  551 ? -11.366 -9.488  -30.2   1    25.031  ? 587  MET   A CE  1 
ATOM   4460 N  N   . SER   A 1  552 ? -16.462 -9.158  -34.174 1    22.581  ? 588  SER   A N   1 
ATOM   4461 C  CA  . SER   A 1  552 ? -16.702 -9.142  -35.614 1    23.351  ? 588  SER   A CA  1 
ATOM   4462 C  C   . SER   A 1  552 ? -17.077 -7.714  -35.968 1    19.018  ? 588  SER   A C   1 
ATOM   4463 O  O   . SER   A 1  552 ? -17.864 -7.125  -35.248 1    18.66   ? 588  SER   A O   1 
ATOM   4464 C  CB  . SER   A 1  552 ? -17.874 -10.139 -36.013 1    24.538  ? 588  SER   A CB  1 
ATOM   4465 O  OG  . SER   A 1  552 ? -18.308 -9.874  -37.344 1    21.4    ? 588  SER   A OG  1 
ATOM   4466 N  N   . ALA   A 1  553 ? -16.499 -7.204  -37.054 1    20.601  ? 589  ALA   A N   1 
ATOM   4467 C  CA  . ALA   A 1  553 ? -16.759 -5.865  -37.538 1    17.435  ? 589  ALA   A CA  1 
ATOM   4468 C  C   . ALA   A 1  553 ? -18.032 -5.857  -38.397 1    20.139  ? 589  ALA   A C   1 
ATOM   4469 O  O   . ALA   A 1  553 ? -18.554 -4.798  -38.796 1    19.382  ? 589  ALA   A O   1 
ATOM   4470 C  CB  . ALA   A 1  553 ? -15.553 -5.53   -38.387 1    19.199  ? 589  ALA   A CB  1 
ATOM   4471 N  N   . SER   A 1  554 ? -18.613 -7.052  -38.654 1    22.299  ? 590  SER   A N   1 
ATOM   4472 C  CA  . SER   A 1  554 ? -19.703 -7.077  -39.631 1    23.84   ? 590  SER   A CA  1 
ATOM   4473 C  C   . SER   A 1  554 ? -20.902 -6.23   -39.157 1    20.788  ? 590  SER   A C   1 
ATOM   4474 O  O   . SER   A 1  554 ? -21.51  -5.582  -39.973 1    22.978  ? 590  SER   A O   1 
ATOM   4475 C  CB  . SER   A 1  554 ? -20.077 -8.467  -40.103 1    26.272  ? 590  SER   A CB  1 
ATOM   4476 O  OG  . SER   A 1  554 ? -20.767 -8.975  -38.971 1    31.003  ? 590  SER   A OG  1 
ATOM   4477 N  N   . ALA   A 1  555 ? -21.224 -6.15   -37.855 1    21.523  ? 591  ALA   A N   1 
ATOM   4478 C  CA  . ALA   A 1  555 ? -22.325 -5.315  -37.396 1    20.292  ? 591  ALA   A CA  1 
ATOM   4479 C  C   . ALA   A 1  555 ? -22.013 -3.836  -37.587 1    21.167  ? 591  ALA   A C   1 
ATOM   4480 O  O   . ALA   A 1  555 ? -22.876 -3.073  -38.007 1    20.062  ? 591  ALA   A O   1 
ATOM   4481 C  CB  . ALA   A 1  555 ? -22.657 -5.587  -35.947 1    18.059  ? 591  ALA   A CB  1 
ATOM   4482 N  N   . MET   A 1  556 ? -20.777 -3.406  -37.274 1    20.092  ? 592  MET   A N   1 
ATOM   4483 C  CA  . MET   A 1  556 ? -20.474 -1.996  -37.517 1    19.076  ? 592  MET   A CA  1 
ATOM   4484 C  C   . MET   A 1  556 ? -20.576 -1.711  -39.02  1    18.998  ? 592  MET   A C   1 
ATOM   4485 O  O   . MET   A 1  556 ? -21.014 -0.649  -39.391 1    19.014  ? 592  MET   A O   1 
ATOM   4486 C  CB  . MET   A 1  556 ? -19.048 -1.671  -37.022 1    17.581  ? 592  MET   A CB  1 
ATOM   4487 C  CG  . MET   A 1  556 ? -18.751 -0.184  -37.014 1    16.7    ? 592  MET   A CG  1 
ATOM   4488 S  SD  . MET   A 1  556 ? -17.122 0.092   -36.254 1    21.759  ? 592  MET   A SD  1 
ATOM   4489 C  CE  . MET   A 1  556 ? -17.178 1.87    -36.063 1    22.134  ? 592  MET   A CE  1 
ATOM   4490 N  N   . LEU   A 1  557 ? -20.128 -2.631  -39.895 1    23.542  ? 593  LEU   A N   1 
ATOM   4491 C  CA  . LEU   A 1  557 ? -20.157 -2.418  -41.351 1    22.571  ? 593  LEU   A CA  1 
ATOM   4492 C  C   . LEU   A 1  557 ? -21.608 -2.315  -41.861 1    24.042  ? 593  LEU   A C   1 
ATOM   4493 O  O   . LEU   A 1  557 ? -21.97  -1.405  -42.647 1    23.438  ? 593  LEU   A O   1 
ATOM   4494 C  CB  . LEU   A 1  557 ? -19.401 -3.572  -42.023 1    22.541  ? 593  LEU   A CB  1 
ATOM   4495 C  CG  . LEU   A 1  557 ? -17.897 -3.691  -41.8   1    25.767  ? 593  LEU   A CG  1 
ATOM   4496 C  CD1 . LEU   A 1  557 ? -17.29  -4.773  -42.642 1    24.669  ? 593  LEU   A CD1 1 
ATOM   4497 C  CD2 . LEU   A 1  557 ? -17.216 -2.325  -42.018 1    32.273  ? 593  LEU   A CD2 1 
ATOM   4498 N  N   A SER   A 1  558 ? -22.45  -3.204  -41.337 0.64 22.667  ? 594  SER   A N   1 
ATOM   4499 N  N   B SER   A 1  558 ? -22.443 -3.232  -41.347 0.36 21.666  ? 594  SER   A N   1 
ATOM   4500 C  CA  A SER   A 1  558 ? -23.869 -3.196  -41.654 0.64 22.836  ? 594  SER   A CA  1 
ATOM   4501 C  CA  B SER   A 1  558 ? -23.885 -3.249  -41.56  0.36 20.709  ? 594  SER   A CA  1 
ATOM   4502 C  C   A SER   A 1  558 ? -24.53  -1.883  -41.228 0.64 20.709  ? 594  SER   A C   1 
ATOM   4503 C  C   B SER   A 1  558 ? -24.488 -1.889  -41.234 0.36 19.393  ? 594  SER   A C   1 
ATOM   4504 O  O   A SER   A 1  558 ? -25.261 -1.279  -42.008 0.64 19.375  ? 594  SER   A O   1 
ATOM   4505 O  O   B SER   A 1  558 ? -25.128 -1.281  -42.09  0.36 18.586  ? 594  SER   A O   1 
ATOM   4506 C  CB  A SER   A 1  558 ? -24.546 -4.388  -41.024 0.64 24.311  ? 594  SER   A CB  1 
ATOM   4507 C  CB  B SER   A 1  558 ? -24.556 -4.324  -40.722 0.36 20.194  ? 594  SER   A CB  1 
ATOM   4508 O  OG  A SER   A 1  558 ? -25.936 -4.14   -40.988 0.64 24.114  ? 594  SER   A OG  1 
ATOM   4509 O  OG  B SER   A 1  558 ? -24.171 -5.607  -41.184 0.36 18.66   ? 594  SER   A OG  1 
ATOM   4510 N  N   . TYR   A 1  559 ? -24.29  -1.441  -39.985 1    16.682  ? 595  TYR   A N   1 
ATOM   4511 C  CA  . TYR   A 1  559 ? -24.767 -0.134  -39.558 1    18.484  ? 595  TYR   A CA  1 
ATOM   4512 C  C   . TYR   A 1  559 ? -24.388 0.979   -40.569 1    17.576  ? 595  TYR   A C   1 
ATOM   4513 O  O   . TYR   A 1  559 ? -25.251 1.82    -40.884 1    19.824  ? 595  TYR   A O   1 
ATOM   4514 C  CB  . TYR   A 1  559 ? -24.248 0.136   -38.129 1    17.971  ? 595  TYR   A CB  1 
ATOM   4515 C  CG  . TYR   A 1  559 ? -24.681 1.458   -37.5   1    18.566  ? 595  TYR   A CG  1 
ATOM   4516 C  CD1 . TYR   A 1  559 ? -24.18  2.699   -37.924 1    16.21   ? 595  TYR   A CD1 1 
ATOM   4517 C  CD2 . TYR   A 1  559 ? -25.63  1.464   -36.49  1    19.364  ? 595  TYR   A CD2 1 
ATOM   4518 C  CE1 . TYR   A 1  559 ? -24.602 3.874   -37.33  1    15.762  ? 595  TYR   A CE1 1 
ATOM   4519 C  CE2 . TYR   A 1  559 ? -26.076 2.643   -35.884 1    19.847  ? 595  TYR   A CE2 1 
ATOM   4520 C  CZ  . TYR   A 1  559 ? -25.515 3.853   -36.275 1    17.746  ? 595  TYR   A CZ  1 
ATOM   4521 O  OH  . TYR   A 1  559 ? -25.972 4.993   -35.612 1    20.619  ? 595  TYR   A OH  1 
ATOM   4522 N  N   . PHE   A 1  560 ? -23.143 1.013   -41.061 1    17.055  ? 596  PHE   A N   1 
ATOM   4523 C  CA  . PHE   A 1  560 ? -22.618 2.14    -41.859 1    19.553  ? 596  PHE   A CA  1 
ATOM   4524 C  C   . PHE   A 1  560 ? -22.758 1.951   -43.389 1    19.291  ? 596  PHE   A C   1 
ATOM   4525 O  O   . PHE   A 1  560 ? -22.443 2.831   -44.208 1    20.006  ? 596  PHE   A O   1 
ATOM   4526 C  CB  . PHE   A 1  560 ? -21.161 2.448   -41.46  1    17.062  ? 596  PHE   A CB  1 
ATOM   4527 C  CG  . PHE   A 1  560 ? -21.105 3.322   -40.212 1    16.104  ? 596  PHE   A CG  1 
ATOM   4528 C  CD1 . PHE   A 1  560 ? -21.597 4.64    -40.227 1    17.343  ? 596  PHE   A CD1 1 
ATOM   4529 C  CD2 . PHE   A 1  560 ? -20.662 2.792   -38.99  1    18.464  ? 596  PHE   A CD2 1 
ATOM   4530 C  CE1 . PHE   A 1  560 ? -21.601 5.451   -39.068 1    15.19   ? 596  PHE   A CE1 1 
ATOM   4531 C  CE2 . PHE   A 1  560 ? -20.659 3.574   -37.832 1    16.717  ? 596  PHE   A CE2 1 
ATOM   4532 C  CZ  . PHE   A 1  560 ? -21.133 4.895   -37.866 1    19.17   ? 596  PHE   A CZ  1 
ATOM   4533 N  N   . LYS   A 1  561 ? -23.23  0.769   -43.791 1    21.017  ? 597  LYS   A N   1 
ATOM   4534 C  CA  . LYS   A 1  561 ? -23.294 0.367   -45.174 1    20.494  ? 597  LYS   A CA  1 
ATOM   4535 C  C   . LYS   A 1  561 ? -23.855 1.462   -46.062 1    17.43   ? 597  LYS   A C   1 
ATOM   4536 O  O   . LYS   A 1  561 ? -23.232 1.739   -47.068 1    21.218  ? 597  LYS   A O   1 
ATOM   4537 C  CB  . LYS   A 1  561 ? -24.052 -0.976  -45.338 1    24.443  ? 597  LYS   A CB  1 
ATOM   4538 C  CG  . LYS   A 1  561 ? -24.537 -1.376  -46.751 1    26.535  ? 597  LYS   A CG  1 
ATOM   4539 C  CD  . LYS   A 1  561 ? -23.465 -1.913  -47.677 1    32.721  ? 597  LYS   A CD  1 
ATOM   4540 C  CE  . LYS   A 1  561 ? -24.017 -2.26   -49.148 1    33.716  ? 597  LYS   A CE  1 
ATOM   4541 N  NZ  . LYS   A 1  561 ? -22.764 -2.244  -49.925 1    29.971  ? 597  LYS   A NZ  1 
ATOM   4542 N  N   . PRO   A 1  562 ? -25.014 2.111   -45.799 1    19.945  ? 598  PRO   A N   1 
ATOM   4543 C  CA  . PRO   A 1  562 ? -25.518 3.121   -46.733 1    24.961  ? 598  PRO   A CA  1 
ATOM   4544 C  C   . PRO   A 1  562 ? -24.564 4.308   -46.797 1    25.87   ? 598  PRO   A C   1 
ATOM   4545 O  O   . PRO   A 1  562 ? -24.573 5.03    -47.803 1    27.039  ? 598  PRO   A O   1 
ATOM   4546 C  CB  . PRO   A 1  562 ? -26.889 3.53    -46.097 1    25.933  ? 598  PRO   A CB  1 
ATOM   4547 C  CG  . PRO   A 1  562 ? -27.263 2.347   -45.244 1    21.153  ? 598  PRO   A CG  1 
ATOM   4548 C  CD  . PRO   A 1  562 ? -25.944 1.905   -44.674 1    22.179  ? 598  PRO   A CD  1 
ATOM   4549 N  N   . LEU   A 1  563 ? -23.846 4.592   -45.688 1    21.437  ? 599  LEU   A N   1 
ATOM   4550 C  CA  . LEU   A 1  563 ? -22.85  5.652   -45.728 1    20.587  ? 599  LEU   A CA  1 
ATOM   4551 C  C   . LEU   A 1  563 ? -21.638 5.254   -46.551 1    20.245  ? 599  LEU   A C   1 
ATOM   4552 O  O   . LEU   A 1  563 ? -21.063 6.083   -47.274 1    22.144  ? 599  LEU   A O   1 
ATOM   4553 C  CB  . LEU   A 1  563 ? -22.443 6.09    -44.326 1    21.959  ? 599  LEU   A CB  1 
ATOM   4554 C  CG  . LEU   A 1  563 ? -21.431 7.251   -44.387 1    26.027  ? 599  LEU   A CG  1 
ATOM   4555 C  CD1 . LEU   A 1  563 ? -22.245 8.523   -44.81  1    21.818  ? 599  LEU   A CD1 1 
ATOM   4556 C  CD2 . LEU   A 1  563 ? -20.715 7.435   -43.017 1    20.067  ? 599  LEU   A CD2 1 
ATOM   4557 N  N   . LEU   A 1  564 ? -21.19  3.989   -46.432 1    18.715  ? 600  LEU   A N   1 
ATOM   4558 C  CA  . LEU   A 1  564 ? -20.085 3.525   -47.257 1    20.829  ? 600  LEU   A CA  1 
ATOM   4559 C  C   . LEU   A 1  564 ? -20.421 3.675   -48.755 1    22.295  ? 600  LEU   A C   1 
ATOM   4560 O  O   . LEU   A 1  564 ? -19.568 4.141   -49.5   1    20.027  ? 600  LEU   A O   1 
ATOM   4561 C  CB  . LEU   A 1  564 ? -19.64  2.101   -46.97  1    21.495  ? 600  LEU   A CB  1 
ATOM   4562 C  CG  . LEU   A 1  564 ? -18.456 1.617   -47.819 1    23.592  ? 600  LEU   A CG  1 
ATOM   4563 C  CD1 . LEU   A 1  564 ? -17.219 2.416   -47.477 1    22.88   ? 600  LEU   A CD1 1 
ATOM   4564 C  CD2 . LEU   A 1  564 ? -18.212 0.091   -47.522 1    28.144  ? 600  LEU   A CD2 1 
ATOM   4565 N  N   . ASP   A 1  565 ? -21.654 3.329   -49.168 1    20.863  ? 601  ASP   A N   1 
ATOM   4566 C  CA  . ASP   A 1  565 ? -22.036 3.455   -50.562 1    19.965  ? 601  ASP   A CA  1 
ATOM   4567 C  C   . ASP   A 1  565 ? -22.015 4.938   -50.951 1    22.48   ? 601  ASP   A C   1 
ATOM   4568 O  O   . ASP   A 1  565 ? -21.545 5.266   -52.041 1    19.373  ? 601  ASP   A O   1 
ATOM   4569 C  CB  . ASP   A 1  565 ? -23.416 2.853   -50.763 1    24.172  ? 601  ASP   A CB  1 
ATOM   4570 C  CG  . ASP   A 1  565 ? -23.47  1.353   -50.557 1    25.806  ? 601  ASP   A CG  1 
ATOM   4571 O  OD1 . ASP   A 1  565 ? -22.392 0.735   -50.585 1    30.714  ? 601  ASP   A OD1 1 
ATOM   4572 O  OD2 . ASP   A 1  565 ? -24.571 0.812   -50.41  1    30.2    ? 601  ASP   A OD2 1 
ATOM   4573 N  N   . TRP   A 1  566 ? -22.573 5.808   -50.098 1    21.93   ? 602  TRP   A N   1 
ATOM   4574 C  CA  . TRP   A 1  566 ? -22.636 7.244   -50.396 1    22.427  ? 602  TRP   A CA  1 
ATOM   4575 C  C   . TRP   A 1  566 ? -21.227 7.866   -50.559 1    22.156  ? 602  TRP   A C   1 
ATOM   4576 O  O   . TRP   A 1  566 ? -20.941 8.594   -51.497 1    21.143  ? 602  TRP   A O   1 
ATOM   4577 C  CB  . TRP   A 1  566 ? -23.483 7.969   -49.334 1    23.987  ? 602  TRP   A CB  1 
ATOM   4578 C  CG  . TRP   A 1  566 ? -23.655 9.416   -49.699 1    21.897  ? 602  TRP   A CG  1 
ATOM   4579 C  CD1 . TRP   A 1  566 ? -24.67  9.934   -50.464 1    24.248  ? 602  TRP   A CD1 1 
ATOM   4580 C  CD2 . TRP   A 1  566 ? -22.75  10.508  -49.375 1    23.08   ? 602  TRP   A CD2 1 
ATOM   4581 N  NE1 . TRP   A 1  566 ? -24.474 11.296  -50.591 1    24.949  ? 602  TRP   A NE1 1 
ATOM   4582 C  CE2 . TRP   A 1  566 ? -23.295 11.682  -49.961 1    25.732  ? 602  TRP   A CE2 1 
ATOM   4583 C  CE3 . TRP   A 1  566 ? -21.563 10.629  -48.619 1    21.91   ? 602  TRP   A CE3 1 
ATOM   4584 C  CZ2 . TRP   A 1  566 ? -22.656 12.939  -49.866 1    23.251  ? 602  TRP   A CZ2 1 
ATOM   4585 C  CZ3 . TRP   A 1  566 ? -20.933 11.871  -48.535 1    22.257  ? 602  TRP   A CZ3 1 
ATOM   4586 C  CH2 . TRP   A 1  566 ? -21.488 13.024  -49.115 1    23.986  ? 602  TRP   A CH2 1 
ATOM   4587 N  N   . LEU   A 1  567 ? -20.307 7.558   -49.64  1    21.103  ? 603  LEU   A N   1 
ATOM   4588 C  CA  . LEU   A 1  567 ? -18.918 8.034   -49.576 1    21.71   ? 603  LEU   A CA  1 
ATOM   4589 C  C   . LEU   A 1  567 ? -18.152 7.608   -50.844 1    21.667  ? 603  LEU   A C   1 
ATOM   4590 O  O   . LEU   A 1  567 ? -17.366 8.361   -51.427 1    18.598  ? 603  LEU   A O   1 
ATOM   4591 C  CB  . LEU   A 1  567 ? -18.229 7.432   -48.316 1    17.995  ? 603  LEU   A CB  1 
ATOM   4592 C  CG  . LEU   A 1  567 ? -18.576 8.116   -46.987 1    21.81   ? 603  LEU   A CG  1 
ATOM   4593 C  CD1 . LEU   A 1  567 ? -17.944 7.376   -45.775 1    18.577  ? 603  LEU   A CD1 1 
ATOM   4594 C  CD2 . LEU   A 1  567 ? -18.101 9.599   -47.084 1    18.723  ? 603  LEU   A CD2 1 
ATOM   4595 N  N   . ARG   A 1  568 ? -18.347 6.353   -51.276 1    23.141  ? 604  ARG   A N   1 
ATOM   4596 C  CA  . ARG   A 1  568 ? -17.644 5.888   -52.475 1    23.4    ? 604  ARG   A CA  1 
ATOM   4597 C  C   . ARG   A 1  568 ? -18.16  6.614   -53.709 1    21.413  ? 604  ARG   A C   1 
ATOM   4598 O  O   . ARG   A 1  568 ? -17.338 7.087   -54.477 1    22.435  ? 604  ARG   A O   1 
ATOM   4599 C  CB  . ARG   A 1  568 ? -17.744 4.384   -52.757 1    25.216  ? 604  ARG   A CB  1 
ATOM   4600 C  CG  . ARG   A 1  568 ? -16.977 3.629   -51.688 1    26.2    ? 604  ARG   A CG  1 
ATOM   4601 C  CD  . ARG   A 1  568 ? -17.04  2.216   -52.195 1    36.798  ? 604  ARG   A CD  1 
ATOM   4602 N  NE  . ARG   A 1  568 ? -16.116 1.369   -51.433 1    41.196  ? 604  ARG   A NE  1 
ATOM   4603 C  CZ  . ARG   A 1  568 ? -16.505 0.185   -50.948 1    42.152  ? 604  ARG   A CZ  1 
ATOM   4604 N  NH1 . ARG   A 1  568 ? -17.772 -0.19   -51.054 1    35.97   ? 604  ARG   A NH1 1 
ATOM   4605 N  NH2 . ARG   A 1  568 ? -15.632 -0.636  -50.387 1    41.377  ? 604  ARG   A NH2 1 
ATOM   4606 N  N   . THR   A 1  569 ? -19.498 6.732   -53.862 1    19.305  ? 605  THR   A N   1 
ATOM   4607 C  CA  . THR   A 1  569 ? -20.029 7.504   -54.968 1    22.156  ? 605  THR   A CA  1 
ATOM   4608 C  C   . THR   A 1  569 ? -19.437 8.915   -54.873 1    21.878  ? 605  THR   A C   1 
ATOM   4609 O  O   . THR   A 1  569 ? -18.94  9.425   -55.857 1    19.507  ? 605  THR   A O   1 
ATOM   4610 C  CB  . THR   A 1  569 ? -21.556 7.528   -54.875 1    26.161  ? 605  THR   A CB  1 
ATOM   4611 O  OG1 . THR   A 1  569 ? -21.715 6.134   -55.161 1    25.648  ? 605  THR   A OG1 1 
ATOM   4612 C  CG2 . THR   A 1  569 ? -22.212 8.527   -55.841 1    27.302  ? 605  THR   A CG2 1 
ATOM   4613 N  N   . GLU   A 1  570 ? -19.465 9.538   -53.684 1    20.867  ? 606  GLU   A N   1 
ATOM   4614 C  CA  . GLU   A 1  570 ? -19.07  10.963  -53.548 1    21.024  ? 606  GLU   A CA  1 
ATOM   4615 C  C   . GLU   A 1  570 ? -17.572 11.153  -53.819 1    19.101  ? 606  GLU   A C   1 
ATOM   4616 O  O   . GLU   A 1  570 ? -17.133 12.117  -54.47  1    21.644  ? 606  GLU   A O   1 
ATOM   4617 C  CB  . GLU   A 1  570 ? -19.499 11.506  -52.169 1    18.975  ? 606  GLU   A CB  1 
ATOM   4618 C  CG  . GLU   A 1  570 ? -18.775 12.822  -51.825 1    23.331  ? 606  GLU   A CG  1 
ATOM   4619 C  CD  . GLU   A 1  570 ? -19.524 13.982  -52.488 1    28.656  ? 606  GLU   A CD  1 
ATOM   4620 O  OE1 . GLU   A 1  570 ? -20.552 13.719  -53.167 1    25.848  ? 606  GLU   A OE1 1 
ATOM   4621 O  OE2 . GLU   A 1  570 ? -19.125 15.132  -52.322 1    30.3    ? 606  GLU   A OE2 1 
ATOM   4622 N  N   . ASN   A 1  571 ? -16.759 10.256  -53.269 1    17.685  ? 607  ASN   A N   1 
ATOM   4623 C  CA  . ASN   A 1  571 ? -15.309 10.362  -53.374 1    19.676  ? 607  ASN   A CA  1 
ATOM   4624 C  C   . ASN   A 1  571 ? -14.883 10.021  -54.813 1    20.784  ? 607  ASN   A C   1 
ATOM   4625 O  O   . ASN   A 1  571 ? -14.021 10.679  -55.346 1    17.428  ? 607  ASN   A O   1 
ATOM   4626 C  CB  . ASN   A 1  571 ? -14.564 9.396   -52.442 1    20.781  ? 607  ASN   A CB  1 
ATOM   4627 C  CG  . ASN   A 1  571 ? -14.523 9.914   -50.993 1    20.329  ? 607  ASN   A CG  1 
ATOM   4628 O  OD1 . ASN   A 1  571 ? -14.665 11.135  -50.758 1    21.72   ? 607  ASN   A OD1 1 
ATOM   4629 N  ND2 . ASN   A 1  571 ? -14.376 9.01    -50.015 1    18.843  ? 607  ASN   A ND2 1 
ATOM   4630 N  N   A GLU   A 1  572 ? -15.563 9.023   -55.424 0.5  20.275  ? 608  GLU   A N   1 
ATOM   4631 N  N   B GLU   A 1  572 ? -15.556 9.058   -55.473 0.5  22.199  ? 608  GLU   A N   1 
ATOM   4632 C  CA  A GLU   A 1  572 ? -15.327 8.653   -56.821 0.5  20.331  ? 608  GLU   A CA  1 
ATOM   4633 C  CA  B GLU   A 1  572 ? -15.188 8.745   -56.856 0.5  22.38   ? 608  GLU   A CA  1 
ATOM   4634 C  C   A GLU   A 1  572 ? -15.553 9.857   -57.756 0.5  20.222  ? 608  GLU   A C   1 
ATOM   4635 C  C   B GLU   A 1  572 ? -15.561 9.883   -57.824 0.5  21.255  ? 608  GLU   A C   1 
ATOM   4636 O  O   A GLU   A 1  572 ? -14.681 10.182  -58.545 0.5  22.273  ? 608  GLU   A O   1 
ATOM   4637 O  O   B GLU   A 1  572 ? -14.811 10.196  -58.729 0.5  24.38   ? 608  GLU   A O   1 
ATOM   4638 C  CB  A GLU   A 1  572 ? -16.292 7.546   -57.241 0.5  18.953  ? 608  GLU   A CB  1 
ATOM   4639 C  CB  B GLU   A 1  572 ? -15.789 7.406   -57.254 0.5  23.982  ? 608  GLU   A CB  1 
ATOM   4640 C  CG  A GLU   A 1  572 ? -16.203 7.264   -58.739 0.5  19.428  ? 608  GLU   A CG  1 
ATOM   4641 C  CG  B GLU   A 1  572 ? -14.982 6.274   -56.644 0.5  24.952  ? 608  GLU   A CG  1 
ATOM   4642 C  CD  A GLU   A 1  572 ? -17.23  6.175   -58.992 0.5  18.33   ? 608  GLU   A CD  1 
ATOM   4643 C  CD  B GLU   A 1  572 ? -15.653 4.935   -56.828 0.5  26.443  ? 608  GLU   A CD  1 
ATOM   4644 O  OE1 A GLU   A 1  572 ? -16.91  5.1     -58.5   0.5  22.943  ? 608  GLU   A OE1 1 
ATOM   4645 O  OE1 B GLU   A 1  572 ? -16.878 4.946   -57.048 0.5  27.491  ? 608  GLU   A OE1 1 
ATOM   4646 O  OE2 A GLU   A 1  572 ? -18.323 6.368   -59.507 0.5  15.116  ? 608  GLU   A OE2 1 
ATOM   4647 O  OE2 B GLU   A 1  572 ? -14.932 3.934   -56.782 0.5  22.885  ? 608  GLU   A OE2 1 
ATOM   4648 N  N   . LEU   A 1  573 ? -16.652 10.6    -57.583 1    21.21   ? 609  LEU   A N   1 
ATOM   4649 C  CA  . LEU   A 1  573 ? -16.961 11.687  -58.495 1    24.398  ? 609  LEU   A CA  1 
ATOM   4650 C  C   . LEU   A 1  573 ? -15.982 12.854  -58.332 1    25.222  ? 609  LEU   A C   1 
ATOM   4651 O  O   . LEU   A 1  573 ? -15.759 13.593  -59.287 1    25.1    ? 609  LEU   A O   1 
ATOM   4652 C  CB  . LEU   A 1  573 ? -18.427 12.081  -58.5   1    30.596  ? 609  LEU   A CB  1 
ATOM   4653 C  CG  . LEU   A 1  573 ? -18.949 12.853  -57.297 1    27.488  ? 609  LEU   A CG  1 
ATOM   4654 C  CD1 . LEU   A 1  573 ? -18.677 14.329  -57.494 1    26.977  ? 609  LEU   A CD1 1 
ATOM   4655 C  CD2 . LEU   A 1  573 ? -20.471 12.574  -57.268 1    31.442  ? 609  LEU   A CD2 1 
ATOM   4656 N  N   . HIS   A 1  574 ? -15.32  12.933  -57.15  1    27.363  ? 610  HIS   A N   1 
ATOM   4657 C  CA  . HIS   A 1  574 ? -14.309 13.953  -56.86  1    24.671  ? 610  HIS   A CA  1 
ATOM   4658 C  C   . HIS   A 1  574 ? -12.922 13.481  -57.232 1    24.933  ? 610  HIS   A C   1 
ATOM   4659 O  O   . HIS   A 1  574 ? -12.038 14.316  -57.192 1    28.913  ? 610  HIS   A O   1 
ATOM   4660 C  CB  . HIS   A 1  574 ? -14.313 14.5    -55.426 1    23.939  ? 610  HIS   A CB  1 
ATOM   4661 C  CG  . HIS   A 1  574 ? -15.506 15.345  -55.168 1    26.688  ? 610  HIS   A CG  1 
ATOM   4662 N  ND1 . HIS   A 1  574 ? -15.686 16.608  -55.701 1    31.391  ? 610  HIS   A ND1 1 
ATOM   4663 C  CD2 . HIS   A 1  574 ? -16.658 15.043  -54.526 1    23.297  ? 610  HIS   A CD2 1 
ATOM   4664 C  CE1 . HIS   A 1  574 ? -16.929 17.024  -55.416 1    29.049  ? 610  HIS   A CE1 1 
ATOM   4665 N  NE2 . HIS   A 1  574 ? -17.542 16.107  -54.668 1    26.062  ? 610  HIS   A NE2 1 
ATOM   4666 N  N   . GLY   A 1  575 ? -12.746 12.212  -57.676 1    23.05   ? 611  GLY   A N   1 
ATOM   4667 C  CA  . GLY   A 1  575 ? -11.415 11.671  -57.979 1    23.349  ? 611  GLY   A CA  1 
ATOM   4668 C  C   . GLY   A 1  575 ? -10.47  11.514  -56.781 1    25.503  ? 611  GLY   A C   1 
ATOM   4669 O  O   . GLY   A 1  575 ? -9.237  11.558  -56.906 1    24.208  ? 611  GLY   A O   1 
ATOM   4670 N  N   . GLU   A 1  576 ? -11.019 11.37   -55.574 1    23.389  ? 612  GLU   A N   1 
ATOM   4671 C  CA  . GLU   A 1  576 ? -10.128 11.281  -54.432 1    22.11   ? 612  GLU   A CA  1 
ATOM   4672 C  C   . GLU   A 1  576 ? -9.224  10.063  -54.549 1    24.685  ? 612  GLU   A C   1 
ATOM   4673 O  O   . GLU   A 1  576 ? -9.637  8.963   -54.943 1    28.534  ? 612  GLU   A O   1 
ATOM   4674 C  CB  . GLU   A 1  576 ? -10.884 11.13   -53.107 1    25.681  ? 612  GLU   A CB  1 
ATOM   4675 C  CG  . GLU   A 1  576 ? -12.024 12.129  -52.908 1    19.18   ? 612  GLU   A CG  1 
ATOM   4676 C  CD  . GLU   A 1  576 ? -11.528 13.559  -52.854 1    19.717  ? 612  GLU   A CD  1 
ATOM   4677 O  OE1 . GLU   A 1  576 ? -10.278 13.886  -52.938 1    20.207  ? 612  GLU   A OE1 1 
ATOM   4678 O  OE2 . GLU   A 1  576 ? -12.459 14.374  -52.718 1    20.952  ? 612  GLU   A OE2 1 
ATOM   4679 N  N   . LYS   A 1  577 ? -7.961  10.258  -54.149 1    23.802  ? 613  LYS   A N   1 
ATOM   4680 C  CA  . LYS   A 1  577 ? -7.043  9.131   -54.067 1    27.774  ? 613  LYS   A CA  1 
ATOM   4681 C  C   . LYS   A 1  577 ? -7.079  8.763   -52.584 1    27.423  ? 613  LYS   A C   1 
ATOM   4682 O  O   . LYS   A 1  577 ? -6.552  9.528   -51.766 1    32.34   ? 613  LYS   A O   1 
ATOM   4683 C  CB  . LYS   A 1  577 ? -5.592  9.62    -54.297 1    33.019  ? 613  LYS   A CB  1 
ATOM   4684 C  CG  . LYS   A 1  577 ? -5.298  10.393  -55.578 1    57.527  ? 613  LYS   A CG  1 
ATOM   4685 C  CD  . LYS   A 1  577 ? -5.203  9.681   -56.922 1    67.391  ? 613  LYS   A CD  1 
ATOM   4686 C  CE  . LYS   A 1  577 ? -4.25   10.482  -57.774 1    75.929  ? 613  LYS   A CE  1 
ATOM   4687 N  NZ  . LYS   A 1  577 ? -4.74   10.592  -59.148 1    77.078  ? 613  LYS   A NZ  1 
ATOM   4688 N  N   . LEU   A 1  578 ? -7.697  7.636   -52.215 1    23.758  ? 614  LEU   A N   1 
ATOM   4689 C  CA  . LEU   A 1  578 ? -7.807  7.27    -50.805 1    23.702  ? 614  LEU   A CA  1 
ATOM   4690 C  C   . LEU   A 1  578 ? -6.435  7.021   -50.192 1    30.318  ? 614  LEU   A C   1 
ATOM   4691 O  O   . LEU   A 1  578 ? -5.565  6.48    -50.849 1    32.143  ? 614  LEU   A O   1 
ATOM   4692 C  CB  . LEU   A 1  578 ? -8.616  5.99    -50.715 1    23.321  ? 614  LEU   A CB  1 
ATOM   4693 C  CG  . LEU   A 1  578 ? -10.05  6.091   -51.226 1    23.603  ? 614  LEU   A CG  1 
ATOM   4694 C  CD1 . LEU   A 1  578 ? -10.724 4.736   -51.017 1    21.628  ? 614  LEU   A CD1 1 
ATOM   4695 C  CD2 . LEU   A 1  578 ? -10.739 7.267   -50.57  1    24.849  ? 614  LEU   A CD2 1 
ATOM   4696 N  N   . GLY   A 1  579 ? -6.276  7.276   -48.881 1    24.484  ? 615  GLY   A N   1 
ATOM   4697 C  CA  . GLY   A 1  579 ? -5.008  6.964   -48.277 1    20.36   ? 615  GLY   A CA  1 
ATOM   4698 C  C   . GLY   A 1  579 ? -4.113  8.186   -48.393 1    21.811  ? 615  GLY   A C   1 
ATOM   4699 O  O   . GLY   A 1  579 ? -4.547  9.3     -48.744 1    25.131  ? 615  GLY   A O   1 
ATOM   4700 N  N   . TRP   A 1  580 ? -2.851  7.982   -48.093 1    21.239  ? 616  TRP   A N   1 
ATOM   4701 C  CA  . TRP   A 1  580 ? -1.917  9.097   -48.106 1    24.91   ? 616  TRP   A CA  1 
ATOM   4702 C  C   . TRP   A 1  580 ? -0.564  8.664   -48.716 1    32.653  ? 616  TRP   A C   1 
ATOM   4703 O  O   . TRP   A 1  580 ? 0.327   8.201   -47.995 1    30.405  ? 616  TRP   A O   1 
ATOM   4704 C  CB  . TRP   A 1  580 ? -1.861  9.711   -46.697 1    22.383  ? 616  TRP   A CB  1 
ATOM   4705 C  CG  . TRP   A 1  580 ? -1.99   8.702   -45.566 1    22.817  ? 616  TRP   A CG  1 
ATOM   4706 C  CD1 . TRP   A 1  580 ? -0.943  8.069   -44.928 1    26.368  ? 616  TRP   A CD1 1 
ATOM   4707 C  CD2 . TRP   A 1  580 ? -3.204  8.208   -44.956 1    21.386  ? 616  TRP   A CD2 1 
ATOM   4708 N  NE1 . TRP   A 1  580 ? -1.439  7.222   -43.959 1    23.596  ? 616  TRP   A NE1 1 
ATOM   4709 C  CE2 . TRP   A 1  580 ? -2.823  7.278   -43.96  1    22.706  ? 616  TRP   A CE2 1 
ATOM   4710 C  CE3 . TRP   A 1  580 ? -4.587  8.443   -45.144 1    21.328  ? 616  TRP   A CE3 1 
ATOM   4711 C  CZ2 . TRP   A 1  580 ? -3.759  6.574   -43.192 1    20.917  ? 616  TRP   A CZ2 1 
ATOM   4712 C  CZ3 . TRP   A 1  580 ? -5.515  7.729   -44.408 1    23.534  ? 616  TRP   A CZ3 1 
ATOM   4713 C  CH2 . TRP   A 1  580 ? -5.105  6.775   -43.448 1    19.556  ? 616  TRP   A CH2 1 
HETATM 4714 C  C1  . NAG   B 2  .   ? -17.305 -23.703 -7.618  1    39.533  ? 1    NAG   B C1  1 
HETATM 4715 C  C2  . NAG   B 2  .   ? -18.667 -24.36  -7.794  1    49.904  ? 1    NAG   B C2  1 
HETATM 4716 C  C3  . NAG   B 2  .   ? -19.668 -23.26  -8.122  1    51.613  ? 1    NAG   B C3  1 
HETATM 4717 C  C4  . NAG   B 2  .   ? -19.626 -22.156 -7.071  1    51.051  ? 1    NAG   B C4  1 
HETATM 4718 C  C5  . NAG   B 2  .   ? -18.22  -21.581 -6.962  1    49.477  ? 1    NAG   B C5  1 
HETATM 4719 C  C6  . NAG   B 2  .   ? -18.067 -20.541 -5.854  1    46.348  ? 1    NAG   B C6  1 
HETATM 4720 C  C7  . NAG   B 2  .   ? -18.696 -26.701 -8.669  1    78.994  ? 1    NAG   B C7  1 
HETATM 4721 C  C8  . NAG   B 2  .   ? -17.718 -27.538 -9.454  1    69.023  ? 1    NAG   B C8  1 
HETATM 4722 N  N2  . NAG   B 2  .   ? -18.645 -25.37  -8.838  1    65.871  ? 1    NAG   B N2  1 
HETATM 4723 O  O3  . NAG   B 2  .   ? -20.964 -23.829 -8.161  1    52.435  ? 1    NAG   B O3  1 
HETATM 4724 O  O4  . NAG   B 2  .   ? -20.46  -21.114 -7.519  1    45.297  ? 1    NAG   B O4  1 
HETATM 4725 O  O5  . NAG   B 2  .   ? -17.34  -22.676 -6.631  1    42.426  ? 1    NAG   B O5  1 
HETATM 4726 O  O6  . NAG   B 2  .   ? -18.531 -21.044 -4.572  1    49.435  ? 1    NAG   B O6  1 
HETATM 4727 O  O7  . NAG   B 2  .   ? -19.514 -27.206 -7.905  1    79.225  ? 1    NAG   B O7  1 
HETATM 4728 C  C1  . NAG   B 2  .   ? -21.558 -20.828 -6.728  1    46.738  ? 2    NAG   B C1  1 
HETATM 4729 C  C2  . NAG   B 2  .   ? -21.99  -19.475 -7.272  1    46.414  ? 2    NAG   B C2  1 
HETATM 4730 C  C3  . NAG   B 2  .   ? -23.284 -19.043 -6.597  1    52.967  ? 2    NAG   B C3  1 
HETATM 4731 C  C4  . NAG   B 2  .   ? -24.406 -20.053 -6.789  1    57.436  ? 2    NAG   B C4  1 
HETATM 4732 C  C5  . NAG   B 2  .   ? -23.878 -21.438 -6.43   1    58.362  ? 2    NAG   B C5  1 
HETATM 4733 C  C6  . NAG   B 2  .   ? -24.822 -22.502 -6.907  1    61.171  ? 2    NAG   B C6  1 
HETATM 4734 C  C7  . NAG   B 2  .   ? -20.22  -17.875 -7.869  1    51.287  ? 2    NAG   B C7  1 
HETATM 4735 C  C8  . NAG   B 2  .   ? -19.619 -16.561 -7.452  1    52.082  ? 2    NAG   B C8  1 
HETATM 4736 N  N2  . NAG   B 2  .   ? -21.009 -18.459 -6.968  1    44.672  ? 2    NAG   B N2  1 
HETATM 4737 O  O3  . NAG   B 2  .   ? -23.61  -17.849 -7.278  1    56.596  ? 2    NAG   B O3  1 
HETATM 4738 O  O4  . NAG   B 2  .   ? -25.588 -19.684 -6.001  1    69.613  ? 2    NAG   B O4  1 
HETATM 4739 O  O5  . NAG   B 2  .   ? -22.579 -21.776 -6.994  1    50.08   ? 2    NAG   B O5  1 
HETATM 4740 O  O6  . NAG   B 2  .   ? -24.567 -23.601 -6.067  1    60.356  ? 2    NAG   B O6  1 
HETATM 4741 O  O7  . NAG   B 2  .   ? -20.01  -18.385 -8.965  1    44.687  ? 2    NAG   B O7  1 
HETATM 4742 C  C1  . BMA   B 2  .   ? -26.732 -19.037 -6.506  1    86.388  ? 3    BMA   B C1  1 
HETATM 4743 C  C2  . BMA   B 2  .   ? -28.04  -19.843 -6.372  1    97.724  ? 3    BMA   B C2  1 
HETATM 4744 C  C3  . BMA   B 2  .   ? -29.29  -19.067 -6.941  1    83.344  ? 3    BMA   B C3  1 
HETATM 4745 C  C4  . BMA   B 2  .   ? -29.342 -17.688 -6.341  1    77.275  ? 3    BMA   B C4  1 
HETATM 4746 C  C5  . BMA   B 2  .   ? -28.039 -17.034 -6.804  1    88.113  ? 3    BMA   B C5  1 
HETATM 4747 C  C6  . BMA   B 2  .   ? -27.971 -15.516 -6.703  1    75.182  ? 3    BMA   B C6  1 
HETATM 4748 O  O2  . BMA   B 2  .   ? -28.179 -20.271 -5.018  1    102.522 ? 3    BMA   B O2  1 
HETATM 4749 O  O3  . BMA   B 2  .   ? -30.579 -19.695 -6.893  1    68.634  ? 3    BMA   B O3  1 
HETATM 4750 O  O4  . BMA   B 2  .   ? -30.478 -17.024 -6.842  1    85.503  ? 3    BMA   B O4  1 
HETATM 4751 O  O5  . BMA   B 2  .   ? -26.932 -17.683 -6.065  1    76.399  ? 3    BMA   B O5  1 
HETATM 4752 O  O6  . BMA   B 2  .   ? -27.545 -15.096 -5.437  1    77.004  ? 3    BMA   B O6  1 
HETATM 4753 C  C1  . FUC   B 2  .   ? -19.082 -20.037 -3.765  0.89 44.863  ? 4    FUC   B C1  1 
HETATM 4754 C  C2  . FUC   B 2  .   ? -19.853 -20.695 -2.623  0.89 46.112  ? 4    FUC   B C2  1 
HETATM 4755 C  C3  . FUC   B 2  .   ? -18.99  -21.676 -1.899  0.89 52.306  ? 4    FUC   B C3  1 
HETATM 4756 C  C4  . FUC   B 2  .   ? -17.705 -20.981 -1.415  0.89 47.899  ? 4    FUC   B C4  1 
HETATM 4757 C  C5  . FUC   B 2  .   ? -17.003 -20.389 -2.634  0.89 46.546  ? 4    FUC   B C5  1 
HETATM 4758 C  C6  . FUC   B 2  .   ? -15.704 -19.687 -2.317  0.89 36.09   ? 4    FUC   B C6  1 
HETATM 4759 O  O2  . FUC   B 2  .   ? -21.058 -21.318 -3.058  0.89 51.608  ? 4    FUC   B O2  1 
HETATM 4760 O  O3  . FUC   B 2  .   ? -19.766 -22.173 -0.813  0.89 56.576  ? 4    FUC   B O3  1 
HETATM 4761 O  O4  . FUC   B 2  .   ? -17.961 -19.906 -0.475  0.89 39.306  ? 4    FUC   B O4  1 
HETATM 4762 O  O5  . FUC   B 2  .   ? -17.901 -19.427 -3.245  0.89 42.127  ? 4    FUC   B O5  1 
HETATM 4763 ZN ZN  . ZN    C 3  .   ? -15.322 4.033   -19.984 1    17.449  ? 701  ZN    A ZN  1 
HETATM 4764 C  C1  . PEG   D 4  .   ? -26.278 15.619  -34.995 1    39.136  ? 702  PEG   A C1  1 
HETATM 4765 O  O1  . PEG   D 4  .   ? -26.599 16.923  -35.386 1    43.913  ? 702  PEG   A O1  1 
HETATM 4766 C  C2  . PEG   D 4  .   ? -27.354 14.946  -34.192 1    53.692  ? 702  PEG   A C2  1 
HETATM 4767 O  O2  . PEG   D 4  .   ? -27.186 13.526  -34.308 1    69.726  ? 702  PEG   A O2  1 
HETATM 4768 C  C3  . PEG   D 4  .   ? -26.769 12.861  -33.115 1    56.557  ? 702  PEG   A C3  1 
HETATM 4769 C  C4  . PEG   D 4  .   ? -25.369 12.309  -33.178 1    52.381  ? 702  PEG   A C4  1 
HETATM 4770 O  O4  . PEG   D 4  .   ? -24.786 12.156  -31.874 1    49.902  ? 702  PEG   A O4  1 
HETATM 4771 C  C1  . EDO   E 5  .   ? 5.681   -16.127 -9.739  1    60.792  ? 703  EDO   A C1  1 
HETATM 4772 O  O1  . EDO   E 5  .   ? 5.543   -14.989 -10.592 1    51.434  ? 703  EDO   A O1  1 
HETATM 4773 C  C2  . EDO   E 5  .   ? 4.664   -17.119 -10.157 1    66.071  ? 703  EDO   A C2  1 
HETATM 4774 O  O2  . EDO   E 5  .   ? 3.456   -16.423 -10.479 1    66.584  ? 703  EDO   A O2  1 
HETATM 4775 B  B   . BO3   F 6  .   ? 1.056   -6.954  -13.705 1    43.364  ? 704  BO3   A B   1 
HETATM 4776 O  O1  . BO3   F 6  .   ? 1.793   -7.215  -12.608 1    52.214  ? 704  BO3   A O1  1 
HETATM 4777 O  O2  . BO3   F 6  .   ? -0.158  -7.545  -13.827 1    43.569  ? 704  BO3   A O2  1 
HETATM 4778 O  O3  . BO3   F 6  .   ? 1.557   -6.06   -14.6   1    57.538  ? 704  BO3   A O3  1 
HETATM 4779 CL CL  . CL    G 7  .   ? -0.956  14.178  -30.361 1    23.054  ? 705  CL    A CL  1 
HETATM 4780 CL CL  . CL    H 7  .   ? -7.551  -2.904  -22.111 1    36.408  ? 706  CL    A CL  1 
HETATM 4781 C  C12 . A1IJW I 8  .   ? -13.547 3.708   -15.499 1    19.778  ? 707  A1IJW A C12 1 
HETATM 4782 O  O01 . A1IJW I 8  .   ? -11.692 8.46    -21.443 1    19.416  ? 707  A1IJW A O01 1 
HETATM 4783 C  C02 . A1IJW I 8  .   ? -12.849 8.243   -21.538 1    15.772  ? 707  A1IJW A C02 1 
HETATM 4784 C  C03 . A1IJW I 8  .   ? -13.878 8.476   -20.421 1    15.714  ? 707  A1IJW A C03 1 
HETATM 4785 N  N04 . A1IJW I 8  .   ? -13.345 8.38    -19.076 1    17.032  ? 707  A1IJW A N04 1 
HETATM 4786 C  C05 . A1IJW I 8  .   ? -12.786 7.091   -18.81  1    15.805  ? 707  A1IJW A C05 1 
HETATM 4787 C  C06 . A1IJW I 8  .   ? -12.518 7.033   -17.303 1    17.773  ? 707  A1IJW A C06 1 
HETATM 4788 C  C07 . A1IJW I 8  .   ? -11.046 7.401   -16.949 1    13.913  ? 707  A1IJW A C07 1 
HETATM 4789 C  C08 . A1IJW I 8  .   ? -10.269 6.011   -17.157 1    19.011  ? 707  A1IJW A C08 1 
HETATM 4790 C  C09 . A1IJW I 8  .   ? -11.228 4.959   -17.226 1    19.579  ? 707  A1IJW A C09 1 
HETATM 4791 N  N10 . A1IJW I 8  .   ? -12.574 5.706   -16.846 1    17.562  ? 707  A1IJW A N10 1 
HETATM 4792 C  C11 . A1IJW I 8  .   ? -13.521 5.203   -15.878 1    19.257  ? 707  A1IJW A C11 1 
HETATM 4793 C  C13 . A1IJW I 8  .   ? -13.863 3.297   -14.184 1    16.96   ? 707  A1IJW A C13 1 
HETATM 4794 C  C14 . A1IJW I 8  .   ? -13.957 1.911   -14.037 1    18.923  ? 707  A1IJW A C14 1 
HETATM 4795 C  C15 . A1IJW I 8  .   ? -13.832 1.034   -15.086 1    19.617  ? 707  A1IJW A C15 1 
HETATM 4796 N  N16 . A1IJW I 8  .   ? -13.979 -0.399  -14.77  1    20.479  ? 707  A1IJW A N16 1 
HETATM 4797 C  C17 . A1IJW I 8  .   ? -13.539 1.426   -16.446 1    19.644  ? 707  A1IJW A C17 1 
HETATM 4798 C  C18 . A1IJW I 8  .   ? -13.412 2.838   -16.645 1    17.683  ? 707  A1IJW A C18 1 
HETATM 4799 O  O19 . A1IJW I 8  .   ? -14.417 5.869   -15.518 1    22.739  ? 707  A1IJW A O19 1 
HETATM 4800 C  C20 . A1IJW I 8  .   ? -13.86  6.029   -19.127 1    16.567  ? 707  A1IJW A C20 1 
HETATM 4801 O  O21 . A1IJW I 8  .   ? -15.105 6.146   -18.647 1    14.584  ? 707  A1IJW A O21 1 
HETATM 4802 O  O22 . A1IJW I 8  .   ? -13.53  5.018   -19.834 1    17.323  ? 707  A1IJW A O22 1 
HETATM 4803 C  C23 . A1IJW I 8  .   ? -14.45  9.892   -20.736 1    13.972  ? 707  A1IJW A C23 1 
HETATM 4804 N  N24 . A1IJW I 8  .   ? -13.267 7.672   -22.825 1    15.68   ? 707  A1IJW A N24 1 
HETATM 4805 C  C25 . A1IJW I 8  .   ? -14.741 7.362   -23.231 1    16.46   ? 707  A1IJW A C25 1 
HETATM 4806 C  C26 . A1IJW I 8  .   ? -14.675 6.92    -24.574 1    17.827  ? 707  A1IJW A C26 1 
HETATM 4807 C  C27 . A1IJW I 8  .   ? -13.2   7.343   -25.165 1    14.673  ? 707  A1IJW A C27 1 
HETATM 4808 C  C28 . A1IJW I 8  .   ? -12.355 7.51    -24.008 1    16.82   ? 707  A1IJW A C28 1 
HETATM 4809 C  C29 . A1IJW I 8  .   ? -11.606 8.877   -24.234 1    18.168  ? 707  A1IJW A C29 1 
HETATM 4810 O  O30 . A1IJW I 8  .   ? -12.287 9.954   -24.012 1    19.161  ? 707  A1IJW A O30 1 
HETATM 4811 O  O31 . A1IJW I 8  .   ? -10.415 8.98    -24.615 1    20.191  ? 707  A1IJW A O31 1 
HETATM 4812 C  C1  . NAG   J 9  .   ? -10.436 19.639  0.505   0.99 66.546  ? 708  NAG   A C1  1 
HETATM 4813 C  C2  . NAG   J 9  .   ? -11.562 19.515  1.53    0.99 67.127  ? 708  NAG   A C2  1 
HETATM 4814 C  C3  . NAG   J 9  .   ? -11.146 20.024  2.916   0.99 69.358  ? 708  NAG   A C3  1 
HETATM 4815 C  C4  . NAG   J 9  .   ? -9.758  19.526  3.348   0.99 75.026  ? 708  NAG   A C4  1 
HETATM 4816 C  C5  . NAG   J 9  .   ? -8.756  19.914  2.255   0.99 67.694  ? 708  NAG   A C5  1 
HETATM 4817 C  C6  . NAG   J 9  .   ? -7.328  19.453  2.479   0.99 68.383  ? 708  NAG   A C6  1 
HETATM 4818 C  C7  . NAG   J 9  .   ? -13.509 20.068  0.129   0.99 59.658  ? 708  NAG   A C7  1 
HETATM 4819 C  C8  . NAG   J 9  .   ? -13.944 21.183  -0.773  0.99 54.094  ? 708  NAG   A C8  1 
HETATM 4820 N  N2  . NAG   J 9  .   ? -12.592 20.396  1.03    0.99 63.453  ? 708  NAG   A N2  1 
HETATM 4821 O  O3  . NAG   J 9  .   ? -12.184 19.656  3.813   0.99 64.111  ? 708  NAG   A O3  1 
HETATM 4822 O  O4  . NAG   J 9  .   ? -9.348  19.961  4.657   0.99 73.404  ? 708  NAG   A O4  1 
HETATM 4823 O  O5  . NAG   J 9  .   ? -9.175  19.243  1.053   0.99 70.7    ? 708  NAG   A O5  1 
HETATM 4824 O  O6  . NAG   J 9  .   ? -7.268  18.031  2.708   0.99 56.608  ? 708  NAG   A O6  1 
HETATM 4825 O  O7  . NAG   J 9  .   ? -13.997 18.944  0.097   0.99 55.645  ? 708  NAG   A O7  1 
HETATM 4826 O  O   . HOH   K 10 .   ? -2.741  6.327   -11.579 1    39.825  ? 801  HOH   A O   1 
HETATM 4827 O  O   . HOH   K 10 .   ? -14.956 14.934  -30.717 1    44.396  ? 802  HOH   A O   1 
HETATM 4828 O  O   . HOH   K 10 .   ? -42.25  4.988   -22.432 1    22.483  ? 803  HOH   A O   1 
HETATM 4829 O  O   . HOH   K 10 .   ? -21.681 5.372   -57.368 1    50.568  ? 804  HOH   A O   1 
HETATM 4830 O  O   . HOH   K 10 .   ? -38.421 -5.443  -26.951 1    42.057  ? 805  HOH   A O   1 
HETATM 4831 O  O   . HOH   K 10 .   ? 0.2     31.315  -40.461 1    44.94   ? 806  HOH   A O   1 
HETATM 4832 O  O   . HOH   K 10 .   ? -11.546 22.302  -52.324 1    43.297  ? 807  HOH   A O   1 
HETATM 4833 O  O   . HOH   K 10 .   ? -0.549  -11.485 -22.769 1    31.791  ? 808  HOH   A O   1 
HETATM 4834 O  O   . HOH   K 10 .   ? 14.327  4.535   -15.933 1    34.288  ? 809  HOH   A O   1 
HETATM 4835 O  O   . HOH   K 10 .   ? 0.432   23.589  -40.179 1    36.923  ? 810  HOH   A O   1 
HETATM 4836 O  O   . HOH   K 10 .   ? -1.804  -11.957 -29.357 1    29.742  ? 811  HOH   A O   1 
HETATM 4837 O  O   . HOH   K 10 .   ? -5.099  13.363  -14.139 1    31.7    ? 812  HOH   A O   1 
HETATM 4838 O  O   . HOH   K 10 .   ? -15.005 -9.277  -38.46  1    32.383  ? 813  HOH   A O   1 
HETATM 4839 O  O   . HOH   K 10 .   ? -1.506  22.623  -43.163 1    32.297  ? 814  HOH   A O   1 
HETATM 4840 O  O   . HOH   K 10 .   ? 3.235   -6.706  -28.912 1    33.045  ? 815  HOH   A O   1 
HETATM 4841 O  O   . HOH   K 10 .   ? -21.832 9.266   -30.64  1    35.039  ? 816  HOH   A O   1 
HETATM 4842 O  O   . HOH   K 10 .   ? -24.754 4.586   -4.743  1    28.664  ? 817  HOH   A O   1 
HETATM 4843 O  O   . HOH   K 10 .   ? -38.854 -0.686  -27.113 1    36.754  ? 818  HOH   A O   1 
HETATM 4844 O  O   . HOH   K 10 .   ? -16.013 -2.495  -10.14  1    16.359  ? 819  HOH   A O   1 
HETATM 4845 O  O   . HOH   K 10 .   ? -5.69   24.092  -13.38  1    48.983  ? 820  HOH   A O   1 
HETATM 4846 O  O   . HOH   K 10 .   ? -10.963 31.071  -32.981 1    30.628  ? 821  HOH   A O   1 
HETATM 4847 O  O   . HOH   K 10 .   ? -3.411  -2.571  -23.616 1    16.106  ? 822  HOH   A O   1 
HETATM 4848 O  O   . HOH   K 10 .   ? -25.836 -14.359 -15.992 1    30.198  ? 823  HOH   A O   1 
HETATM 4849 O  O   . HOH   K 10 .   ? -27.77  0.699   -41.309 1    26.25   ? 824  HOH   A O   1 
HETATM 4850 O  O   . HOH   K 10 .   ? -22.583 12.438  -54.032 1    23.991  ? 825  HOH   A O   1 
HETATM 4851 O  O   . HOH   K 10 .   ? -26.44  5.157   -49.543 1    22.521  ? 826  HOH   A O   1 
HETATM 4852 O  O   . HOH   K 10 .   ? -13.8   5.783   -52.828 1    25.145  ? 827  HOH   A O   1 
HETATM 4853 O  O   . HOH   K 10 .   ? 11.957  -2.219  -15.848 1    23.131  ? 828  HOH   A O   1 
HETATM 4854 O  O   . HOH   K 10 .   ? -18.046 -14.247 -20.263 1    31.446  ? 829  HOH   A O   1 
HETATM 4855 O  O   . HOH   K 10 .   ? -4.879  -11.845 -24.109 1    20.154  ? 830  HOH   A O   1 
HETATM 4856 O  O   . HOH   K 10 .   ? -11.727 17.481  -23.546 1    40.727  ? 831  HOH   A O   1 
HETATM 4857 O  O   . HOH   K 10 .   ? -5.364  -8.465  -4.622  1    34.943  ? 832  HOH   A O   1 
HETATM 4858 O  O   . HOH   K 10 .   ? -28.914 0.673   -28.935 1    19.184  ? 833  HOH   A O   1 
HETATM 4859 O  O   . HOH   K 10 .   ? -28.938 -2.64   -41.415 1    45.787  ? 834  HOH   A O   1 
HETATM 4860 O  O   . HOH   K 10 .   ? -14.365 -16.162 -29.424 1    26.067  ? 835  HOH   A O   1 
HETATM 4861 O  O   . HOH   K 10 .   ? -22.289 15.751  -30.997 1    39.102  ? 836  HOH   A O   1 
HETATM 4862 O  O   . HOH   K 10 .   ? -15.568 15.944  -17.393 1    27.984  ? 837  HOH   A O   1 
HETATM 4863 O  O   . HOH   K 10 .   ? -6.475  21.755  -17.455 1    25.659  ? 838  HOH   A O   1 
HETATM 4864 O  O   . HOH   K 10 .   ? 10.874  11.436  -28.665 1    25.559  ? 839  HOH   A O   1 
HETATM 4865 O  O   . HOH   K 10 .   ? -16.837 2.666   -25.252 1    18.358  ? 840  HOH   A O   1 
HETATM 4866 O  O   . HOH   K 10 .   ? -19.625 19.524  -28.908 1    28.651  ? 841  HOH   A O   1 
HETATM 4867 O  O   . HOH   K 10 .   ? -19.604 -9.738  -17.693 1    18.662  ? 842  HOH   A O   1 
HETATM 4868 O  O   . HOH   K 10 .   ? -37.793 10.484  -24.709 1    41.947  ? 843  HOH   A O   1 
HETATM 4869 O  O   . HOH   K 10 .   ? 9.955   15.132  -30.773 1    47.752  ? 844  HOH   A O   1 
HETATM 4870 O  O   . HOH   K 10 .   ? -35.504 -1.181  -13.331 1    39.108  ? 845  HOH   A O   1 
HETATM 4871 O  O   . HOH   K 10 .   ? 0.807   -13.716 3.438   1    35.694  ? 846  HOH   A O   1 
HETATM 4872 O  O   . HOH   K 10 .   ? -7.15   11.373  -0.244  1    29.362  ? 847  HOH   A O   1 
HETATM 4873 O  O   . HOH   K 10 .   ? -19.442 20.311  -8.336  1    43.339  ? 848  HOH   A O   1 
HETATM 4874 O  O   . HOH   K 10 .   ? -19.561 -3.643  -7.591  1    23.315  ? 849  HOH   A O   1 
HETATM 4875 O  O   . HOH   K 10 .   ? -5.345  -9.616  -8.947  1    46.358  ? 850  HOH   A O   1 
HETATM 4876 O  O   . HOH   K 10 .   ? -17.318 -11.338 1.348   1    35.392  ? 851  HOH   A O   1 
HETATM 4877 O  O   . HOH   K 10 .   ? -23.996 -9.491  -8.662  1    29.635  ? 852  HOH   A O   1 
HETATM 4878 O  O   . HOH   K 10 .   ? -11.76  22.521  -37.994 1    19.538  ? 853  HOH   A O   1 
HETATM 4879 O  O   . HOH   K 10 .   ? -16.7   21.894  -26.419 1    37.748  ? 854  HOH   A O   1 
HETATM 4880 O  O   . HOH   K 10 .   ? -27.604 4.748   -33.567 1    21.807  ? 855  HOH   A O   1 
HETATM 4881 O  O   . HOH   K 10 .   ? -9.524  13.804  -50.212 1    19.559  ? 856  HOH   A O   1 
HETATM 4882 O  O   . HOH   K 10 .   ? -15.973 22.519  -45.596 1    24.424  ? 857  HOH   A O   1 
HETATM 4883 O  O   . HOH   K 10 .   ? -8.79   14.755  -20.487 1    22.318  ? 858  HOH   A O   1 
HETATM 4884 O  O   . HOH   K 10 .   ? -20.029 0.136   -4.08   1    25.962  ? 859  HOH   A O   1 
HETATM 4885 O  O   . HOH   K 10 .   ? 9.416   -7.268  -23.356 1    24.393  ? 860  HOH   A O   1 
HETATM 4886 O  O   . HOH   K 10 .   ? -31.672 8.026   -39.669 1    42.772  ? 861  HOH   A O   1 
HETATM 4887 O  O   . HOH   K 10 .   ? -21.7   -6.415  -42.473 1    30.388  ? 862  HOH   A O   1 
HETATM 4888 O  O   . HOH   K 10 .   ? -0.483  -14.255 -38.485 1    41.291  ? 863  HOH   A O   1 
HETATM 4889 O  O   . HOH   K 10 .   ? 11.111  -9.547  -19.603 1    40.976  ? 864  HOH   A O   1 
HETATM 4890 O  O   . HOH   K 10 .   ? -33.785 -11.009 -24.083 1    39.19   ? 865  HOH   A O   1 
HETATM 4891 O  O   . HOH   K 10 .   ? -36.429 -11.104 -28.198 1    33.228  ? 866  HOH   A O   1 
HETATM 4892 O  O   . HOH   K 10 .   ? -14.321 -4.475  -45.004 1    29.283  ? 867  HOH   A O   1 
HETATM 4893 O  O   . HOH   K 10 .   ? -21.196 3.33    -53.817 1    37.027  ? 868  HOH   A O   1 
HETATM 4894 O  O   . HOH   K 10 .   ? -20.845 -8.68   -36.337 1    39.534  ? 869  HOH   A O   1 
HETATM 4895 O  O   . HOH   K 10 .   ? -13.053 -11.653 -4.112  1    30.228  ? 870  HOH   A O   1 
HETATM 4896 O  O   . HOH   K 10 .   ? -14.752 10.941  -24.112 1    18.232  ? 871  HOH   A O   1 
HETATM 4897 O  O   . HOH   K 10 .   ? -29.191 3.573   -14.235 1    24.02   ? 872  HOH   A O   1 
HETATM 4898 O  O   . HOH   K 10 .   ? 0.355   27.963  -39.058 1    31.735  ? 873  HOH   A O   1 
HETATM 4899 O  O   . HOH   K 10 .   ? -30.269 0.11    -7.705  1    29.702  ? 874  HOH   A O   1 
HETATM 4900 O  O   . HOH   K 10 .   ? 15.942  7.71    -18.696 1    37.094  ? 875  HOH   A O   1 
HETATM 4901 O  O   . HOH   K 10 .   ? -4.777  0.77    -28.546 1    22.816  ? 876  HOH   A O   1 
HETATM 4902 O  O   . HOH   K 10 .   ? -1.233  8.251   -12.857 1    28.672  ? 877  HOH   A O   1 
HETATM 4903 O  O   . HOH   K 10 .   ? -5.391  11.127  -13.483 1    43.386  ? 878  HOH   A O   1 
HETATM 4904 O  O   . HOH   K 10 .   ? 12.077  3.352   -19.266 1    17.986  ? 879  HOH   A O   1 
HETATM 4905 O  O   . HOH   K 10 .   ? -29.567 3.069   -34.462 1    22.915  ? 880  HOH   A O   1 
HETATM 4906 O  O   . HOH   K 10 .   ? -3.676  18.776  -52.779 1    22.142  ? 881  HOH   A O   1 
HETATM 4907 O  O   . HOH   K 10 .   ? -6.589  -16.744 -28.795 1    43.882  ? 882  HOH   A O   1 
HETATM 4908 O  O   . HOH   K 10 .   ? -13.641 30.494  -35.804 1    24.725  ? 883  HOH   A O   1 
HETATM 4909 O  O   . HOH   K 10 .   ? -35.177 -6.317  -18.863 1    30.706  ? 884  HOH   A O   1 
HETATM 4910 O  O   . HOH   K 10 .   ? 10.516  -4.542  -21.534 1    25.719  ? 885  HOH   A O   1 
HETATM 4911 O  O   . HOH   K 10 .   ? -15.899 -7.566  4.534   1    31.351  ? 886  HOH   A O   1 
HETATM 4912 O  O   . HOH   K 10 .   ? -12.771 -1.037  -19.136 1    17.732  ? 887  HOH   A O   1 
HETATM 4913 O  O   . HOH   K 10 .   ? -15.157 -6.891  -44.327 1    46.307  ? 888  HOH   A O   1 
HETATM 4914 O  O   . HOH   K 10 .   ? -23.096 6.609   -3.978  1    30.465  ? 889  HOH   A O   1 
HETATM 4915 O  O   . HOH   K 10 .   ? -30.435 11.244  -3.387  1    46.411  ? 890  HOH   A O   1 
HETATM 4916 O  O   . HOH   K 10 .   ? -6.014  31.515  -38.163 1    36.531  ? 891  HOH   A O   1 
HETATM 4917 O  O   . HOH   K 10 .   ? 9.29    16.817  -18.342 1    32.904  ? 892  HOH   A O   1 
HETATM 4918 O  O   . HOH   K 10 .   ? -8.179  18.252  -34.214 1    17.61   ? 893  HOH   A O   1 
HETATM 4919 O  O   . HOH   K 10 .   ? -10.94  -13.154 -30.246 1    25.023  ? 894  HOH   A O   1 
HETATM 4920 O  O   . HOH   K 10 .   ? -10.998 10.59   -13.438 1    31.014  ? 895  HOH   A O   1 
HETATM 4921 O  O   . HOH   K 10 .   ? 0.663   20.886  -14.853 1    23.202  ? 896  HOH   A O   1 
HETATM 4922 O  O   . HOH   K 10 .   ? -34.738 16.376  -46.489 1    50.201  ? 897  HOH   A O   1 
HETATM 4923 O  O   . HOH   K 10 .   ? 4.204   -4.863  -24.623 1    19.287  ? 898  HOH   A O   1 
HETATM 4924 O  O   . HOH   K 10 .   ? -12.25  23.154  -35.358 1    31.542  ? 899  HOH   A O   1 
HETATM 4925 O  O   . HOH   K 10 .   ? -3.739  17.281  -46.158 1    37.132  ? 900  HOH   A O   1 
HETATM 4926 O  O   . HOH   K 10 .   ? -4.732  16.158  -32.284 1    15.801  ? 901  HOH   A O   1 
HETATM 4927 O  O   . HOH   K 10 .   ? -19.585 8.485   -58.357 1    25.84   ? 902  HOH   A O   1 
HETATM 4928 O  O   . HOH   K 10 .   ? -24.649 -9.044  -33.337 1    25.135  ? 903  HOH   A O   1 
HETATM 4929 O  O   . HOH   K 10 .   ? -31.814 6.914   -9.606  1    31.304  ? 904  HOH   A O   1 
HETATM 4930 O  O   . HOH   K 10 .   ? -22.11  22.636  -16.968 1    35.633  ? 905  HOH   A O   1 
HETATM 4931 O  O   . HOH   K 10 .   ? 2.747   -11.056 -25.196 1    29.673  ? 906  HOH   A O   1 
HETATM 4932 O  O   . HOH   K 10 .   ? -16.671 15.724  -51.303 1    22.251  ? 907  HOH   A O   1 
HETATM 4933 O  O   . HOH   K 10 .   ? -36.998 7.567   -15.082 1    37.472  ? 908  HOH   A O   1 
HETATM 4934 O  O   . HOH   K 10 .   ? -12.651 8.496   -59.221 1    28.911  ? 909  HOH   A O   1 
HETATM 4935 O  O   . HOH   K 10 .   ? -11.049 12.374  -24.192 1    21.853  ? 910  HOH   A O   1 
HETATM 4936 O  O   . HOH   K 10 .   ? -5.338  8.218   -8.447  1    37.623  ? 911  HOH   A O   1 
HETATM 4937 O  O   . HOH   K 10 .   ? 2.072   11.858  -38.346 1    29.952  ? 912  HOH   A O   1 
HETATM 4938 O  O   . HOH   K 10 .   ? -18.327 18.103  -47.431 1    48.722  ? 913  HOH   A O   1 
HETATM 4939 O  O   . HOH   K 10 .   ? -2.285  5.381   -47.499 1    43.183  ? 914  HOH   A O   1 
HETATM 4940 O  O   . HOH   K 10 .   ? 11.799  9.399   -15.532 1    26.12   ? 915  HOH   A O   1 
HETATM 4941 O  O   . HOH   K 10 .   ? -5.606  -6.187  -2.968  1    36.695  ? 916  HOH   A O   1 
HETATM 4942 O  O   . HOH   K 10 .   ? -1.243  0.797   -14.573 1    30.54   ? 917  HOH   A O   1 
HETATM 4943 O  O   . HOH   K 10 .   ? 4.245   5.834   -40.517 1    38.515  ? 918  HOH   A O   1 
HETATM 4944 O  O   . HOH   K 10 .   ? -1.981  -12.652 -32.196 1    25.19   ? 919  HOH   A O   1 
HETATM 4945 O  O   . HOH   K 10 .   ? -9.049  9.316   -36.874 1    19.29   ? 920  HOH   A O   1 
HETATM 4946 O  O   . HOH   K 10 .   ? 2.553   -2.385  -31.335 1    27.615  ? 921  HOH   A O   1 
HETATM 4947 O  O   . HOH   K 10 .   ? -40.032 -4.702  -24.072 1    40.18   ? 922  HOH   A O   1 
HETATM 4948 O  O   . HOH   K 10 .   ? -10.44  21.505  -34.662 1    23.402  ? 923  HOH   A O   1 
HETATM 4949 O  O   . HOH   K 10 .   ? -9.287  18.74   -56.771 1    41.145  ? 924  HOH   A O   1 
HETATM 4950 O  O   . HOH   K 10 .   ? 10.77   2.02    -23.478 1    17.659  ? 925  HOH   A O   1 
HETATM 4951 O  O   . HOH   K 10 .   ? -2.928  -5.75   -32.941 1    34.419  ? 926  HOH   A O   1 
HETATM 4952 O  O   . HOH   K 10 .   ? -25.311 20.397  -32.768 1    40.343  ? 927  HOH   A O   1 
HETATM 4953 O  O   . HOH   K 10 .   ? -20.524 -17.617 -13.839 1    41.208  ? 928  HOH   A O   1 
HETATM 4954 O  O   . HOH   K 10 .   ? 2.771   -3.698  -13.893 1    28.774  ? 929  HOH   A O   1 
HETATM 4955 O  O   . HOH   K 10 .   ? -20.112 -0.996  -44.631 1    35.879  ? 930  HOH   A O   1 
HETATM 4956 O  O   . HOH   K 10 .   ? -18.783 21.32   -15.251 1    29.608  ? 931  HOH   A O   1 
HETATM 4957 O  O   . HOH   K 10 .   ? -20.159 0.856   -52.186 1    37.327  ? 932  HOH   A O   1 
HETATM 4958 O  O   . HOH   K 10 .   ? -19.181 -5.538  -1.822  1    40.559  ? 933  HOH   A O   1 
HETATM 4959 O  O   . HOH   K 10 .   ? -19.669 24.204  -12.939 1    45.152  ? 934  HOH   A O   1 
HETATM 4960 O  O   . HOH   K 10 .   ? -10.93  -15.49  -26.018 1    29.131  ? 935  HOH   A O   1 
HETATM 4961 O  O   . HOH   K 10 .   ? 8.384   -2.981  -32.463 1    54.767  ? 936  HOH   A O   1 
HETATM 4962 O  O   . HOH   K 10 .   ? -13.268 19.598  -28.565 1    16.872  ? 937  HOH   A O   1 
HETATM 4963 O  O   . HOH   K 10 .   ? -8.113  8.576   -47.291 1    22.86   ? 938  HOH   A O   1 
HETATM 4964 O  O   . HOH   K 10 .   ? -19.05  -4.637  -35.295 1    17.925  ? 939  HOH   A O   1 
HETATM 4965 O  O   . HOH   K 10 .   ? -14.967 13.703  -51.722 1    22.007  ? 940  HOH   A O   1 
HETATM 4966 O  O   . HOH   K 10 .   ? -19.024 12.103  -26.566 1    26.832  ? 941  HOH   A O   1 
HETATM 4967 O  O   . HOH   K 10 .   ? -1.966  -14.329 -12.436 1    31.224  ? 942  HOH   A O   1 
HETATM 4968 O  O   . HOH   K 10 .   ? -17.574 -13.496 -17.447 1    19.788  ? 943  HOH   A O   1 
HETATM 4969 O  O   . HOH   K 10 .   ? -13.98  15.814  -1.945  1    39.864  ? 944  HOH   A O   1 
HETATM 4970 O  O   . HOH   K 10 .   ? -12.3   -7.129  -17.523 1    18.615  ? 945  HOH   A O   1 
HETATM 4971 O  O   . HOH   K 10 .   ? 4.522   17.427  -26.066 1    19.802  ? 946  HOH   A O   1 
HETATM 4972 O  O   . HOH   K 10 .   ? 0.828   4.991   -19.64  1    18.009  ? 947  HOH   A O   1 
HETATM 4973 O  O   . HOH   K 10 .   ? 4.753   20.199  -27.09  1    20.145  ? 948  HOH   A O   1 
HETATM 4974 O  O   . HOH   K 10 .   ? -3.835  9.886   -51.37  1    37.08   ? 949  HOH   A O   1 
HETATM 4975 O  O   . HOH   K 10 .   ? -3.022  -10.094 -4.609  1    44.812  ? 950  HOH   A O   1 
HETATM 4976 O  O   . HOH   K 10 .   ? -13.39  -4.694  -16.922 1    21.767  ? 951  HOH   A O   1 
HETATM 4977 O  O   . HOH   K 10 .   ? -12.693 -14.154 -3.373  1    30.704  ? 952  HOH   A O   1 
HETATM 4978 O  O   . HOH   K 10 .   ? -27.07  -1.438  -4.435  1    47.01   ? 953  HOH   A O   1 
HETATM 4979 O  O   . HOH   K 10 .   ? 9.48    12.234  -26.178 1    32.114  ? 954  HOH   A O   1 
HETATM 4980 O  O   . HOH   K 10 .   ? -33.133 -4.176  -12.93  1    32.233  ? 955  HOH   A O   1 
HETATM 4981 O  O   . HOH   K 10 .   ? -22.687 24.189  -23.775 1    42.85   ? 956  HOH   A O   1 
HETATM 4982 O  O   . HOH   K 10 .   ? -18.133 4.13    0.651   1    31      ? 957  HOH   A O   1 
HETATM 4983 O  O   . HOH   K 10 .   ? 5.399   -7.861  -24.944 1    22.945  ? 958  HOH   A O   1 
HETATM 4984 O  O   . HOH   K 10 .   ? -7.664  12.926  -53.19  1    19.417  ? 959  HOH   A O   1 
HETATM 4985 O  O   . HOH   K 10 .   ? -14.305 16.88   -28.637 1    31.39   ? 960  HOH   A O   1 
HETATM 4986 O  O   . HOH   K 10 .   ? -12.203 13.637  -26.455 1    20.997  ? 961  HOH   A O   1 
HETATM 4987 O  O   . HOH   K 10 .   ? -8.58   10.039  -12.446 1    40.163  ? 962  HOH   A O   1 
HETATM 4988 O  O   . HOH   K 10 .   ? -0.606  -1.834  -9.937  1    34.223  ? 963  HOH   A O   1 
HETATM 4989 O  O   . HOH   K 10 .   ? -0.111  0.854   -3.783  1    39.353  ? 964  HOH   A O   1 
HETATM 4990 O  O   . HOH   K 10 .   ? -25.374 -14.673 -34.062 1    31.547  ? 965  HOH   A O   1 
HETATM 4991 O  O   . HOH   K 10 .   ? -18.262 -4.247  1.891   1    36.056  ? 966  HOH   A O   1 
HETATM 4992 O  O   . HOH   K 10 .   ? -22.279 17.687  -8.39   1    31.866  ? 967  HOH   A O   1 
HETATM 4993 O  O   . HOH   K 10 .   ? 9.906   -5.745  -18.989 1    26.331  ? 968  HOH   A O   1 
HETATM 4994 O  O   . HOH   K 10 .   ? 1.87    -7.586  3.768   1    35.287  ? 969  HOH   A O   1 
HETATM 4995 O  O   . HOH   K 10 .   ? -18.197 26.731  -34.88  1    39.156  ? 970  HOH   A O   1 
HETATM 4996 O  O   . HOH   K 10 .   ? 8.582   -12.713 -16.097 1    40.252  ? 971  HOH   A O   1 
HETATM 4997 O  O   . HOH   K 10 .   ? -28.779 24.453  -39.393 1    56.942  ? 972  HOH   A O   1 
HETATM 4998 O  O   . HOH   K 10 .   ? -8.892  18.507  -14.716 1    26.664  ? 973  HOH   A O   1 
HETATM 4999 O  O   . HOH   K 10 .   ? -17.684 6.748   -26.372 1    26.06   ? 974  HOH   A O   1 
HETATM 5000 O  O   . HOH   K 10 .   ? -22.524 5.632   -28.328 1    21.324  ? 975  HOH   A O   1 
HETATM 5001 O  O   . HOH   K 10 .   ? -14.707 16.637  -33.095 1    19.142  ? 976  HOH   A O   1 
HETATM 5002 O  O   . HOH   K 10 .   ? -22.813 9.906   -53.15  1    31.307  ? 977  HOH   A O   1 
HETATM 5003 O  O   . HOH   K 10 .   ? -11.206 18.229  -27.372 1    19.055  ? 978  HOH   A O   1 
HETATM 5004 O  O   . HOH   K 10 .   ? -8.405  15.464  -15.728 1    24.658  ? 979  HOH   A O   1 
HETATM 5005 O  O   . HOH   K 10 .   ? -32.86  4.257   -7.066  1    34.073  ? 980  HOH   A O   1 
HETATM 5006 O  O   . HOH   K 10 .   ? -1.904  13.651  -27.279 1    18.636  ? 981  HOH   A O   1 
HETATM 5007 O  O   . HOH   K 10 .   ? -14.845 -0.741  -43.829 1    26.653  ? 982  HOH   A O   1 
HETATM 5008 O  O   . HOH   K 10 .   ? -1.146  21.723  -49.995 1    44.191  ? 983  HOH   A O   1 
HETATM 5009 O  O   . HOH   K 10 .   ? -19.483 -2.934  -5.078  1    24.967  ? 984  HOH   A O   1 
HETATM 5010 O  O   . HOH   K 10 .   ? -6.452  18.877  -17.462 1    29.822  ? 985  HOH   A O   1 
HETATM 5011 O  O   . HOH   K 10 .   ? -13.792 13.984  -19.5   1    20.245  ? 986  HOH   A O   1 
HETATM 5012 O  O   . HOH   K 10 .   ? -0.142  24.926  -43.754 1    35.067  ? 987  HOH   A O   1 
HETATM 5013 O  O   . HOH   K 10 .   ? -4.095  21.177  -52.313 1    29.742  ? 988  HOH   A O   1 
HETATM 5014 O  O   . HOH   K 10 .   ? -37.607 4.311   -17.296 1    30.083  ? 989  HOH   A O   1 
HETATM 5015 O  O   . HOH   K 10 .   ? -0.486  6.822   -6.768  1    32.337  ? 990  HOH   A O   1 
HETATM 5016 O  O   . HOH   K 10 .   ? -13.338 1.84    -50.989 1    29.382  ? 991  HOH   A O   1 
HETATM 5017 O  O   . HOH   K 10 .   ? 4.457   -17.504 -1.715  1    38.997  ? 992  HOH   A O   1 
HETATM 5018 O  O   . HOH   K 10 .   ? -14.432 -9.04   -26.937 1    23.466  ? 993  HOH   A O   1 
HETATM 5019 O  O   . HOH   K 10 .   ? -40.404 0.63    -18.221 1    31.824  ? 994  HOH   A O   1 
HETATM 5020 O  O   . HOH   K 10 .   ? -28.685 4.902   -1.761  1    28.181  ? 995  HOH   A O   1 
HETATM 5021 O  O   . HOH   K 10 .   ? -0.81   30.03   -34.029 1    31.944  ? 996  HOH   A O   1 
HETATM 5022 O  O   . HOH   K 10 .   ? -10.79  6.528   2.898   1    38.741  ? 997  HOH   A O   1 
HETATM 5023 O  O   . HOH   K 10 .   ? -31.182 -5.78   -13.76  1    38.25   ? 998  HOH   A O   1 
HETATM 5024 O  O   . HOH   K 10 .   ? 5.259   18.074  -13.364 1    41.145  ? 999  HOH   A O   1 
HETATM 5025 O  O   . HOH   K 10 .   ? -21.781 18.329  -28.555 1    27.159  ? 1000 HOH   A O   1 
HETATM 5026 O  O   . HOH   K 10 .   ? 11.017  3.981   -21.763 1    23.683  ? 1001 HOH   A O   1 
HETATM 5027 O  O   . HOH   K 10 .   ? -6.227  -9.482  6.449   1    23.217  ? 1002 HOH   A O   1 
HETATM 5028 O  O   . HOH   K 10 .   ? -27.035 2.749   -1.742  1    44.94   ? 1003 HOH   A O   1 
HETATM 5029 O  O   . HOH   K 10 .   ? -18.911 23.964  -19.36  1    52.33   ? 1004 HOH   A O   1 
HETATM 5030 O  O   . HOH   K 10 .   ? -30.069 16.497  -41.18  1    36.858  ? 1005 HOH   A O   1 
HETATM 5031 O  O   . HOH   K 10 .   ? -36.227 0.538   -33.329 1    34.784  ? 1006 HOH   A O   1 
HETATM 5032 O  O   . HOH   K 10 .   ? -20.116 1.753   -20.232 1    15.727  ? 1007 HOH   A O   1 
HETATM 5033 O  O   . HOH   K 10 .   ? -5.235  -4.224  -22.214 1    33.206  ? 1008 HOH   A O   1 
HETATM 5034 O  O   . HOH   K 10 .   ? -24.839 13.417  -52.52  1    38.554  ? 1009 HOH   A O   1 
HETATM 5035 O  O   . HOH   K 10 .   ? -7.947  29.52   -41.045 1    26.235  ? 1010 HOH   A O   1 
HETATM 5036 O  O   . HOH   K 10 .   ? -14.423 17.779  -21.772 1    35.84   ? 1011 HOH   A O   1 
HETATM 5037 O  O   . HOH   K 10 .   ? 2.364   27.789  -48.968 1    31.35   ? 1012 HOH   A O   1 
HETATM 5038 O  O   . HOH   K 10 .   ? -12.989 -12.901 -31.633 1    26.931  ? 1013 HOH   A O   1 
HETATM 5039 O  O   . HOH   K 10 .   ? 0.277   24.69   -16.436 1    38.301  ? 1014 HOH   A O   1 
HETATM 5040 O  O   . HOH   K 10 .   ? 4.484   7.188   -2.517  1    29.596  ? 1015 HOH   A O   1 
HETATM 5041 O  O   . HOH   K 10 .   ? 8.822   23.176  -35.05  1    38.084  ? 1016 HOH   A O   1 
HETATM 5042 O  O   . HOH   K 10 .   ? -7.516  22.014  -15.008 1    39.096  ? 1017 HOH   A O   1 
HETATM 5043 O  O   . HOH   K 10 .   ? -16.659 21.547  -22.864 1    33.93   ? 1018 HOH   A O   1 
HETATM 5044 O  O   . HOH   K 10 .   ? -31.751 6.544   -37.246 1    33.031  ? 1019 HOH   A O   1 
HETATM 5045 O  O   . HOH   K 10 .   ? -8.12   5.715   -54.354 1    35.648  ? 1020 HOH   A O   1 
HETATM 5046 O  O   . HOH   K 10 .   ? -24.573 16.034  -51.512 1    46.524  ? 1021 HOH   A O   1 
HETATM 5047 O  O   . HOH   K 10 .   ? -12.178 7.601   -54.568 1    30.197  ? 1022 HOH   A O   1 
HETATM 5048 O  O   . HOH   K 10 .   ? -22.122 -10.229 -33.589 1    26.753  ? 1023 HOH   A O   1 
HETATM 5049 O  O   . HOH   K 10 .   ? -23.718 7.555   -29.765 1    20.356  ? 1024 HOH   A O   1 
HETATM 5050 O  O   . HOH   K 10 .   ? -30.679 -11.436 -31.049 1    31.723  ? 1025 HOH   A O   1 
HETATM 5051 O  O   . HOH   K 10 .   ? -8.973  11.377  1.897   1    30.167  ? 1026 HOH   A O   1 
HETATM 5052 O  O   . HOH   K 10 .   ? 8.527   9.289   -7.262  1    40.456  ? 1027 HOH   A O   1 
HETATM 5053 O  O   . HOH   K 10 .   ? -8.274  26.824  -51.83  1    33.911  ? 1028 HOH   A O   1 
HETATM 5054 O  O   . HOH   K 10 .   ? -26.553 2.566   -14.335 1    18.647  ? 1029 HOH   A O   1 
HETATM 5055 O  O   . HOH   K 10 .   ? -27.266 -6.894  -9.101  1    32.827  ? 1030 HOH   A O   1 
HETATM 5056 O  O   . HOH   K 10 .   ? 14.035  -2.737  -14.208 1    39.021  ? 1031 HOH   A O   1 
HETATM 5057 O  O   . HOH   K 10 .   ? -9.28   -8.502  -42.15  1    39.083  ? 1032 HOH   A O   1 
HETATM 5058 O  O   . HOH   K 10 .   ? 5.448   -7.247  -27.717 1    42.497  ? 1033 HOH   A O   1 
HETATM 5059 O  O   . HOH   K 10 .   ? -16.111 16.944  -48.885 1    21.774  ? 1034 HOH   A O   1 
HETATM 5060 O  O   . HOH   K 10 .   ? -20.514 21.102  -36.094 1    31.888  ? 1035 HOH   A O   1 
HETATM 5061 O  O   . HOH   K 10 .   ? -24.25  5.659   -53.742 1    39.279  ? 1036 HOH   A O   1 
HETATM 5062 O  O   . HOH   K 10 .   ? -40.39  4.146   -34.788 1    55.041  ? 1037 HOH   A O   1 
HETATM 5063 O  O   . HOH   K 10 .   ? -3.306  1.723   -41.602 1    40.563  ? 1038 HOH   A O   1 
HETATM 5064 O  O   . HOH   K 10 .   ? -22.272 3.529   1.252   1    33.851  ? 1039 HOH   A O   1 
HETATM 5065 O  O   . HOH   K 10 .   ? -40.797 5.875   -20.178 1    39.468  ? 1040 HOH   A O   1 
HETATM 5066 O  O   . HOH   K 10 .   ? 7.735   10.46   -37.104 1    33.275  ? 1041 HOH   A O   1 
HETATM 5067 O  O   . HOH   K 10 .   ? -31.47  24.886  -31.355 1    29.054  ? 1042 HOH   A O   1 
HETATM 5068 O  O   . HOH   K 10 .   ? 7.636   16.413  -36.682 1    30.729  ? 1043 HOH   A O   1 
HETATM 5069 O  O   . HOH   K 10 .   ? -18.543 -12.656 4.971   1    41.695  ? 1044 HOH   A O   1 
HETATM 5070 O  O   . HOH   K 10 .   ? -8.458  12.889  -22.951 1    28.862  ? 1045 HOH   A O   1 
HETATM 5071 O  O   . HOH   K 10 .   ? -18.767 7.566   -28.39  1    38.284  ? 1046 HOH   A O   1 
HETATM 5072 O  O   . HOH   K 10 .   ? 11.714  -1.524  -18.701 1    21.285  ? 1047 HOH   A O   1 
HETATM 5073 O  O   . HOH   K 10 .   ? -26.829 19.964  -12.459 1    32.148  ? 1048 HOH   A O   1 
HETATM 5074 O  O   . HOH   K 10 .   ? -12.274 -11.356 -34.049 1    33.555  ? 1049 HOH   A O   1 
HETATM 5075 O  O   . HOH   K 10 .   ? -28.083 19.469  -50.019 1    39.338  ? 1050 HOH   A O   1 
HETATM 5076 O  O   . HOH   K 10 .   ? 2.694   5.245   -1.774  1    40.95   ? 1051 HOH   A O   1 
HETATM 5077 O  O   . HOH   K 10 .   ? 13.062  -1.36   -1.104  1    40.006  ? 1052 HOH   A O   1 
HETATM 5078 O  O   . HOH   K 10 .   ? 3.032   25.95   -51.739 1    43.487  ? 1053 HOH   A O   1 
HETATM 5079 O  O   . HOH   K 10 .   ? -26.618 -10.991 -33.012 1    32.078  ? 1054 HOH   A O   1 
HETATM 5080 O  O   . HOH   K 10 .   ? 12.795  12.057  -19.52  1    36.265  ? 1055 HOH   A O   1 
HETATM 5081 O  O   . HOH   K 10 .   ? -10.545 4.088   -6.562  1    38.614  ? 1056 HOH   A O   1 
HETATM 5082 O  O   . HOH   K 10 .   ? -14.296 12.187  -27.658 1    42.545  ? 1057 HOH   A O   1 
HETATM 5083 O  O   . HOH   K 10 .   ? -23.246 -10.065 -1.406  1    47.888  ? 1058 HOH   A O   1 
HETATM 5084 O  O   . HOH   K 10 .   ? -1.435  -3.736  -6.492  1    35.388  ? 1059 HOH   A O   1 
HETATM 5085 O  O   . HOH   K 10 .   ? -32.407 -3.111  -43.703 1    56.387  ? 1060 HOH   A O   1 
HETATM 5086 O  O   . HOH   K 10 .   ? -1.219  -16.451 -11.878 1    40.532  ? 1061 HOH   A O   1 
HETATM 5087 O  O   . HOH   K 10 .   ? -14.141 2.309   -9.85   1    28.119  ? 1062 HOH   A O   1 
HETATM 5088 O  O   . HOH   K 10 .   ? -11.242 28.22   -50.118 1    45.859  ? 1063 HOH   A O   1 
HETATM 5089 O  O   . HOH   K 10 .   ? -16.649 -2.442  1.788   1    35.739  ? 1064 HOH   A O   1 
HETATM 5090 O  O   . HOH   K 10 .   ? -15.268 9.764   -0.207  1    38.881  ? 1065 HOH   A O   1 
HETATM 5091 O  O   . HOH   K 10 .   ? -5.402  -7.141  4.985   1    31.818  ? 1066 HOH   A O   1 
HETATM 5092 O  O   . HOH   K 10 .   ? -18.631 0.386   3.368   1    41.941  ? 1067 HOH   A O   1 
HETATM 5093 O  O   . HOH   K 10 .   ? -23.558 17.858  -34.977 1    52.488  ? 1068 HOH   A O   1 
HETATM 5094 O  O   . HOH   K 10 .   ? -7.963  -2.617  -20.077 1    29.598  ? 1069 HOH   A O   1 
HETATM 5095 O  O   . HOH   K 10 .   ? -5.913  5.946   -13.13  1    38.114  ? 1070 HOH   A O   1 
HETATM 5096 O  O   . HOH   K 10 .   ? -16.323 25.518  -45.603 1    44.927  ? 1071 HOH   A O   1 
HETATM 5097 O  O   . HOH   K 10 .   ? -10.063 1.35    -15.492 1    25.334  ? 1072 HOH   A O   1 
HETATM 5098 O  O   . HOH   K 10 .   ? -12.236 5.438   -11.298 1    44.09   ? 1073 HOH   A O   1 
HETATM 5099 O  O   . HOH   K 10 .   ? -16.004 21.722  -17.291 1    50.684  ? 1074 HOH   A O   1 
HETATM 5100 O  O   . HOH   K 10 .   ? -16.429 18.219  -52.421 1    32.128  ? 1075 HOH   A O   1 
HETATM 5101 O  O   . HOH   K 10 .   ? 1.634   -9.77   -33.705 1    45.952  ? 1076 HOH   A O   1 
HETATM 5102 O  O   . HOH   K 10 .   ? -34.218 7.21    -35.833 1    28.662  ? 1077 HOH   A O   1 
HETATM 5103 O  O   . HOH   K 10 .   ? -17.687 18.718  -24.189 1    33.062  ? 1078 HOH   A O   1 
HETATM 5104 O  O   . HOH   K 10 .   ? -2.526  -11.402 -26.246 1    32.99   ? 1079 HOH   A O   1 
HETATM 5105 O  O   . HOH   K 10 .   ? -12.435 -2.291  -16.954 1    23.07   ? 1080 HOH   A O   1 
HETATM 5106 O  O   . HOH   K 10 .   ? -12.669 16.158  -25.729 1    26.15   ? 1081 HOH   A O   1 
HETATM 5107 O  O   . HOH   K 10 .   ? 6.505   7.765   -40.53  1    38.052  ? 1082 HOH   A O   1 
HETATM 5108 O  O   . HOH   K 10 .   ? -14.942 20.158  -21.4   1    28.796  ? 1083 HOH   A O   1 
HETATM 5109 O  O   . HOH   K 10 .   ? -10.698 15.526  -21.93  1    37.569  ? 1084 HOH   A O   1 
HETATM 5110 O  O   . HOH   K 10 .   ? -15.914 7.78    0.949   1    40.673  ? 1085 HOH   A O   1 
HETATM 5111 O  O   . HOH   K 10 .   ? 14.237  13.274  -29.314 1    43.438  ? 1086 HOH   A O   1 
HETATM 5112 O  O   . HOH   K 10 .   ? -3.241  -6.251  5.08    1    32.881  ? 1087 HOH   A O   1 
HETATM 5113 O  O   . HOH   K 10 .   ? -6.944  13.895  -55.612 1    37.049  ? 1088 HOH   A O   1 
HETATM 5114 O  O   . HOH   K 10 .   ? -29.108 14.144  -37.195 1    41.477  ? 1089 HOH   A O   1 
HETATM 5115 O  O   . HOH   K 10 .   ? 13.844  11.279  -17.718 1    49.672  ? 1090 HOH   A O   1 
HETATM 5116 O  O   . HOH   K 10 .   ? 6.074   10.199  -39.141 1    43.518  ? 1091 HOH   A O   1 
HETATM 5117 O  O   . HOH   K 10 .   ? -22.318 -4.741  -44.605 1    34.98   ? 1092 HOH   A O   1 
HETATM 5118 O  O   . HOH   K 10 .   ? -6.129  33.447  -36.755 1    38.283  ? 1093 HOH   A O   1 
HETATM 5119 O  O   . HOH   K 10 .   ? -27.912 0.783   -2.961  1    47.248  ? 1094 HOH   A O   1 
HETATM 5120 O  O   . HOH   K 10 .   ? -16.681 -1.12   3.809   1    41.446  ? 1095 HOH   A O   1 
HETATM 5121 O  O   . HOH   K 10 .   ? -24.897 -4.825  -44.792 1    46.092  ? 1096 HOH   A O   1 
HETATM 5122 O  O   . HOH   K 10 .   ? -22.661 -12.727 -1.748  1    50.735  ? 1097 HOH   A O   1 
HETATM 5123 O  O   . HOH   K 10 .   ? -17.443 25.979  -13.401 1    54.267  ? 1098 HOH   A O   1 
HETATM 5124 O  O   . HOH   K 10 .   ? -43.127 0.835   -18.937 1    31.241  ? 1099 HOH   A O   1 
HETATM 5125 O  O   . HOH   K 10 .   ? 3.16    -0.619  -34.654 1    32.142  ? 1100 HOH   A O   1 
HETATM 5126 O  O   . HOH   K 10 .   ? -8.726  -17.518 -26.928 1    31.342  ? 1101 HOH   A O   1 
HETATM 5127 O  O   . HOH   K 10 .   ? -15.339 -15.775 -2.961  1    32.908  ? 1102 HOH   A O   1 
HETATM 5128 O  O   . HOH   K 10 .   ? 5.775   -10.648 -25.355 1    31.377  ? 1103 HOH   A O   1 
HETATM 5129 O  O   . HOH   K 10 .   ? -13.409 31.863  -38.421 1    44.724  ? 1104 HOH   A O   1 
HETATM 5130 O  O   . HOH   K 10 .   ? -22.327 19.32   -33.506 1    42.656  ? 1105 HOH   A O   1 
HETATM 5131 O  O   . HOH   K 10 .   ? -17.712 16.358  -4.73   1    39.148  ? 1106 HOH   A O   1 
HETATM 5132 O  O   . HOH   K 10 .   ? -14.802 13.085  -23.121 1    27.84   ? 1107 HOH   A O   1 
HETATM 5133 O  O   . HOH   K 10 .   ? -2.956  3.85    -45.863 1    42.731  ? 1108 HOH   A O   1 
HETATM 5134 O  O   . HOH   K 10 .   ? -13.175 32.069  -33.869 1    40.294  ? 1109 HOH   A O   1 
HETATM 5135 O  O   . HOH   K 10 .   ? -14.472 -18.509 -28.745 1    41.13   ? 1110 HOH   A O   1 
HETATM 5136 O  O   . HOH   K 10 .   ? -11.472 -15.428 -28.679 1    28.974  ? 1111 HOH   A O   1 
HETATM 5137 O  O   . HOH   K 10 .   ? -16.29  25.391  -15.842 1    46.766  ? 1112 HOH   A O   1 
HETATM 5138 O  O   . HOH   K 10 .   ? 13.872  12.776  -21.69  1    36.85   ? 1113 HOH   A O   1 
HETATM 5139 O  O   . HOH   K 10 .   ? -8.81   8.661   3.523   1    53.758  ? 1114 HOH   A O   1 
HETATM 5140 O  O   . HOH   K 10 .   ? 3.739   -4.628  -30.938 1    41.669  ? 1115 HOH   A O   1 
HETATM 5141 O  O   . HOH   K 10 .   ? 6.791   16.991  -38.804 1    34.151  ? 1116 HOH   A O   1 
HETATM 5142 O  O   . HOH   K 10 .   ? -27.711 -1.8    -7.054  1    34.323  ? 1117 HOH   A O   1 
HETATM 5143 O  O   . HOH   K 10 .   ? -7.016  3.779   -12.956 1    46.688  ? 1118 HOH   A O   1 
HETATM 5144 O  O   . HOH   K 10 .   ? -17.503 -5.354  5.05    1    40.448  ? 1119 HOH   A O   1 
HETATM 5145 O  O   . HOH   K 10 .   ? 7.826   13.788  -35.662 1    40.303  ? 1120 HOH   A O   1 
HETATM 5146 O  O   . HOH   K 10 .   ? -8.338  6.888   -13.643 1    41.932  ? 1121 HOH   A O   1 
# 
