data_9GAQ
# 
_entry.id   9GAQ 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9GAQ         pdb_00009gaq 10.2210/pdb9gaq/pdb 
WWPDB D_1292140521 ?            ?                   
EMDB  EMD-51186    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
1 'Structure model' 1 0 2025-01-15 
2 'Structure model' 1 1 2025-02-12 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 2 'Structure model' 'Data collection'     
2 2 'Structure model' 'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation 
2 2 'Structure model' em_admin 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume' 
2 2 'Structure model' '_citation.year'           
3 2 'Structure model' '_em_admin.last_update'    
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9GAQ 
_pdbx_database_status.recvd_initial_deposition_date   2024-07-29 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_database_related.db_name 
_pdbx_database_related.details 
_pdbx_database_related.db_id 
_pdbx_database_related.content_type 
EMDB 'map of the single stranded helical assembly with 12mer RNA'                                     EMD-51184 'other EM volume' 
EMDB 'map of the double stranded parallel helical assembly with 12mer RNA'                            EMD-51185 'other EM volume' 
EMDB 'global map of the double stranded antiparallel helical assembly with 18mer RNA'                 EMD-51188 'other EM volume' 
EMDB 'focused map on Strand 1 of the double stranded antiparallel helical assembly with 18mer RNA'    EMD-51189 'other EM volume' 
EMDB 'focused map on Strand 2 of the double stranded antiparallel helical assembly with 18mer RNA'    EMD-51187 'other EM volume' 
EMDB 'CryoEM structure of influenza A RNP-like particle double-stranded assembled with a 14-mer RNA.' EMD-51186 
'associated EM volume' 
# 
loop_
_pdbx_contact_author.id 
_pdbx_contact_author.email 
_pdbx_contact_author.name_first 
_pdbx_contact_author.name_last 
_pdbx_contact_author.name_mi 
_pdbx_contact_author.role 
_pdbx_contact_author.identifier_ORCID 
2 thibaut.crepin@ibs.fr           Thibaut Crepin           ? 'principal investigator/group leader' 0000-0003-2663-1794 
3 allison.ballandras-colas@ibs.fr Allison Ballandras-Colas ? 'principal investigator/group leader' 0000-0003-4735-4984 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Chenavier, F.'        1 0000-0002-9486-3944 
'Ruigrok, R.W.H.'      2 0000-0002-8094-6642 
'Schoehn, G.'          3 0000-0002-1459-3201 
'Ballandras-Colas, A.' 4 0000-0003-4735-4984 
'Crepin, T.'           5 0000-0003-2663-1794 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Nucleic Acids Res.' 
_citation.journal_id_ASTM           NARHAD 
_citation.journal_id_CSD            0389 
_citation.journal_id_ISSN           1362-4962 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            53 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Influenza a virus antiparallel helical nucleocapsid-like pseudo-atomic structure.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1093/nar/gkae1211 
_citation.pdbx_database_id_PubMed   39673795 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Chenavier, F.'        1 0000-0002-9486-3944 
primary 'Zarkadas, E.'         2 0000-0002-9276-9831 
primary 'Freslon, L.L.'        3 ?                   
primary 'Stelfox, A.J.'        4 0000-0003-4553-6565 
primary 'Schoehn, G.'          5 0000-0002-1459-3201 
primary 'Ruigrok, R.W.H.'      6 0000-0002-8094-6642 
primary 'Ballandras-Colas, A.' 7 0000-0003-4735-4984 
primary 'Crepin, T.'           8 0000-0003-2663-1794 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer syn 
;RNA (5'-P(UC)7-FAM3')
;
4234.475  2 ? ? ? ? 
2 polymer man Nucleoprotein           56150.395 2 ? ? ? ? 
# 
_entity_name_com.entity_id   2 
_entity_name_com.name        'Nucleocapsid protein,Protein N' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 polyribonucleotide no no UCUCUCUCUCUCUC UCUCUCUCUCUCUC C,D ? 
2 'polypeptide(L)'   no no 
;HMTDGERQNATEIRASVGKMIDGIGRFYIQMCTELKLSDYEGRLIQNSLTIERMVLSAFDERRNKYLEEHPSAGKDPKKT
GGPIYRRVDGKWRRELILYDKEEIRRIWRQANNGDDATAGLTHMMIWHSNLNDATYQRTRALVRTGMDPRMCSLMQGSTL
PRRSGAAGAAVKGVGTMVMELIRMIKRGINDRNFWRGENGRRTRIAYERMCNILKGKFQTAAQRTMVDQVRESRNPGNAE
FEDLIFLARSALILRGSVAHKSCLPACVYGSAVASGYDFEREGYSLVGIDPFRLLQNSQVYSLIRPNENPAHKSQLVWMA
CHSAAFEDLRVSSFIRGTKVVPRGKLSTRGVQIASNENMETMESSTLELRSRYWAIRTRSGGNTNQQRASSGQISIQPTF
SVQRNLPFDRPTIMAAFTGNTEGRTSDMRTEIIRLMESARPEDVSFQGRGVFELSDEKATSPIVPSFDMSNEGSYFFGDN
AEEYDNLEHHHHHH
;
;HMTDGERQNATEIRASVGKMIDGIGRFYIQMCTELKLSDYEGRLIQNSLTIERMVLSAFDERRNKYLEEHPSAGKDPKKT
GGPIYRRVDGKWRRELILYDKEEIRRIWRQANNGDDATAGLTHMMIWHSNLNDATYQRTRALVRTGMDPRMCSLMQGSTL
PRRSGAAGAAVKGVGTMVMELIRMIKRGINDRNFWRGENGRRTRIAYERMCNILKGKFQTAAQRTMVDQVRESRNPGNAE
FEDLIFLARSALILRGSVAHKSCLPACVYGSAVASGYDFEREGYSLVGIDPFRLLQNSQVYSLIRPNENPAHKSQLVWMA
CHSAAFEDLRVSSFIRGTKVVPRGKLSTRGVQIASNENMETMESSTLELRSRYWAIRTRSGGNTNQQRASSGQISIQPTF
SVQRNLPFDRPTIMAAFTGNTEGRTSDMRTEIIRLMESARPEDVSFQGRGVFELSDEKATSPIVPSFDMSNEGSYFFGDN
AEEYDNLEHHHHHH
;
B,A ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   U   n 
1 2   C   n 
1 3   U   n 
1 4   C   n 
1 5   U   n 
1 6   C   n 
1 7   U   n 
1 8   C   n 
1 9   U   n 
1 10  C   n 
1 11  U   n 
1 12  C   n 
1 13  U   n 
1 14  C   n 
2 1   HIS n 
2 2   MET n 
2 3   THR n 
2 4   ASP n 
2 5   GLY n 
2 6   GLU n 
2 7   ARG n 
2 8   GLN n 
2 9   ASN n 
2 10  ALA n 
2 11  THR n 
2 12  GLU n 
2 13  ILE n 
2 14  ARG n 
2 15  ALA n 
2 16  SER n 
2 17  VAL n 
2 18  GLY n 
2 19  LYS n 
2 20  MET n 
2 21  ILE n 
2 22  ASP n 
2 23  GLY n 
2 24  ILE n 
2 25  GLY n 
2 26  ARG n 
2 27  PHE n 
2 28  TYR n 
2 29  ILE n 
2 30  GLN n 
2 31  MET n 
2 32  CYS n 
2 33  THR n 
2 34  GLU n 
2 35  LEU n 
2 36  LYS n 
2 37  LEU n 
2 38  SER n 
2 39  ASP n 
2 40  TYR n 
2 41  GLU n 
2 42  GLY n 
2 43  ARG n 
2 44  LEU n 
2 45  ILE n 
2 46  GLN n 
2 47  ASN n 
2 48  SER n 
2 49  LEU n 
2 50  THR n 
2 51  ILE n 
2 52  GLU n 
2 53  ARG n 
2 54  MET n 
2 55  VAL n 
2 56  LEU n 
2 57  SER n 
2 58  ALA n 
2 59  PHE n 
2 60  ASP n 
2 61  GLU n 
2 62  ARG n 
2 63  ARG n 
2 64  ASN n 
2 65  LYS n 
2 66  TYR n 
2 67  LEU n 
2 68  GLU n 
2 69  GLU n 
2 70  HIS n 
2 71  PRO n 
2 72  SER n 
2 73  ALA n 
2 74  GLY n 
2 75  LYS n 
2 76  ASP n 
2 77  PRO n 
2 78  LYS n 
2 79  LYS n 
2 80  THR n 
2 81  GLY n 
2 82  GLY n 
2 83  PRO n 
2 84  ILE n 
2 85  TYR n 
2 86  ARG n 
2 87  ARG n 
2 88  VAL n 
2 89  ASP n 
2 90  GLY n 
2 91  LYS n 
2 92  TRP n 
2 93  ARG n 
2 94  ARG n 
2 95  GLU n 
2 96  LEU n 
2 97  ILE n 
2 98  LEU n 
2 99  TYR n 
2 100 ASP n 
2 101 LYS n 
2 102 GLU n 
2 103 GLU n 
2 104 ILE n 
2 105 ARG n 
2 106 ARG n 
2 107 ILE n 
2 108 TRP n 
2 109 ARG n 
2 110 GLN n 
2 111 ALA n 
2 112 ASN n 
2 113 ASN n 
2 114 GLY n 
2 115 ASP n 
2 116 ASP n 
2 117 ALA n 
2 118 THR n 
2 119 ALA n 
2 120 GLY n 
2 121 LEU n 
2 122 THR n 
2 123 HIS n 
2 124 MET n 
2 125 MET n 
2 126 ILE n 
2 127 TRP n 
2 128 HIS n 
2 129 SER n 
2 130 ASN n 
2 131 LEU n 
2 132 ASN n 
2 133 ASP n 
2 134 ALA n 
2 135 THR n 
2 136 TYR n 
2 137 GLN n 
2 138 ARG n 
2 139 THR n 
2 140 ARG n 
2 141 ALA n 
2 142 LEU n 
2 143 VAL n 
2 144 ARG n 
2 145 THR n 
2 146 GLY n 
2 147 MET n 
2 148 ASP n 
2 149 PRO n 
2 150 ARG n 
2 151 MET n 
2 152 CYS n 
2 153 SER n 
2 154 LEU n 
2 155 MET n 
2 156 GLN n 
2 157 GLY n 
2 158 SER n 
2 159 THR n 
2 160 LEU n 
2 161 PRO n 
2 162 ARG n 
2 163 ARG n 
2 164 SER n 
2 165 GLY n 
2 166 ALA n 
2 167 ALA n 
2 168 GLY n 
2 169 ALA n 
2 170 ALA n 
2 171 VAL n 
2 172 LYS n 
2 173 GLY n 
2 174 VAL n 
2 175 GLY n 
2 176 THR n 
2 177 MET n 
2 178 VAL n 
2 179 MET n 
2 180 GLU n 
2 181 LEU n 
2 182 ILE n 
2 183 ARG n 
2 184 MET n 
2 185 ILE n 
2 186 LYS n 
2 187 ARG n 
2 188 GLY n 
2 189 ILE n 
2 190 ASN n 
2 191 ASP n 
2 192 ARG n 
2 193 ASN n 
2 194 PHE n 
2 195 TRP n 
2 196 ARG n 
2 197 GLY n 
2 198 GLU n 
2 199 ASN n 
2 200 GLY n 
2 201 ARG n 
2 202 ARG n 
2 203 THR n 
2 204 ARG n 
2 205 ILE n 
2 206 ALA n 
2 207 TYR n 
2 208 GLU n 
2 209 ARG n 
2 210 MET n 
2 211 CYS n 
2 212 ASN n 
2 213 ILE n 
2 214 LEU n 
2 215 LYS n 
2 216 GLY n 
2 217 LYS n 
2 218 PHE n 
2 219 GLN n 
2 220 THR n 
2 221 ALA n 
2 222 ALA n 
2 223 GLN n 
2 224 ARG n 
2 225 THR n 
2 226 MET n 
2 227 VAL n 
2 228 ASP n 
2 229 GLN n 
2 230 VAL n 
2 231 ARG n 
2 232 GLU n 
2 233 SER n 
2 234 ARG n 
2 235 ASN n 
2 236 PRO n 
2 237 GLY n 
2 238 ASN n 
2 239 ALA n 
2 240 GLU n 
2 241 PHE n 
2 242 GLU n 
2 243 ASP n 
2 244 LEU n 
2 245 ILE n 
2 246 PHE n 
2 247 LEU n 
2 248 ALA n 
2 249 ARG n 
2 250 SER n 
2 251 ALA n 
2 252 LEU n 
2 253 ILE n 
2 254 LEU n 
2 255 ARG n 
2 256 GLY n 
2 257 SER n 
2 258 VAL n 
2 259 ALA n 
2 260 HIS n 
2 261 LYS n 
2 262 SER n 
2 263 CYS n 
2 264 LEU n 
2 265 PRO n 
2 266 ALA n 
2 267 CYS n 
2 268 VAL n 
2 269 TYR n 
2 270 GLY n 
2 271 SER n 
2 272 ALA n 
2 273 VAL n 
2 274 ALA n 
2 275 SER n 
2 276 GLY n 
2 277 TYR n 
2 278 ASP n 
2 279 PHE n 
2 280 GLU n 
2 281 ARG n 
2 282 GLU n 
2 283 GLY n 
2 284 TYR n 
2 285 SER n 
2 286 LEU n 
2 287 VAL n 
2 288 GLY n 
2 289 ILE n 
2 290 ASP n 
2 291 PRO n 
2 292 PHE n 
2 293 ARG n 
2 294 LEU n 
2 295 LEU n 
2 296 GLN n 
2 297 ASN n 
2 298 SER n 
2 299 GLN n 
2 300 VAL n 
2 301 TYR n 
2 302 SER n 
2 303 LEU n 
2 304 ILE n 
2 305 ARG n 
2 306 PRO n 
2 307 ASN n 
2 308 GLU n 
2 309 ASN n 
2 310 PRO n 
2 311 ALA n 
2 312 HIS n 
2 313 LYS n 
2 314 SER n 
2 315 GLN n 
2 316 LEU n 
2 317 VAL n 
2 318 TRP n 
2 319 MET n 
2 320 ALA n 
2 321 CYS n 
2 322 HIS n 
2 323 SER n 
2 324 ALA n 
2 325 ALA n 
2 326 PHE n 
2 327 GLU n 
2 328 ASP n 
2 329 LEU n 
2 330 ARG n 
2 331 VAL n 
2 332 SER n 
2 333 SER n 
2 334 PHE n 
2 335 ILE n 
2 336 ARG n 
2 337 GLY n 
2 338 THR n 
2 339 LYS n 
2 340 VAL n 
2 341 VAL n 
2 342 PRO n 
2 343 ARG n 
2 344 GLY n 
2 345 LYS n 
2 346 LEU n 
2 347 SER n 
2 348 THR n 
2 349 ARG n 
2 350 GLY n 
2 351 VAL n 
2 352 GLN n 
2 353 ILE n 
2 354 ALA n 
2 355 SER n 
2 356 ASN n 
2 357 GLU n 
2 358 ASN n 
2 359 MET n 
2 360 GLU n 
2 361 THR n 
2 362 MET n 
2 363 GLU n 
2 364 SER n 
2 365 SER n 
2 366 THR n 
2 367 LEU n 
2 368 GLU n 
2 369 LEU n 
2 370 ARG n 
2 371 SER n 
2 372 ARG n 
2 373 TYR n 
2 374 TRP n 
2 375 ALA n 
2 376 ILE n 
2 377 ARG n 
2 378 THR n 
2 379 ARG n 
2 380 SER n 
2 381 GLY n 
2 382 GLY n 
2 383 ASN n 
2 384 THR n 
2 385 ASN n 
2 386 GLN n 
2 387 GLN n 
2 388 ARG n 
2 389 ALA n 
2 390 SER n 
2 391 SER n 
2 392 GLY n 
2 393 GLN n 
2 394 ILE n 
2 395 SER n 
2 396 ILE n 
2 397 GLN n 
2 398 PRO n 
2 399 THR n 
2 400 PHE n 
2 401 SER n 
2 402 VAL n 
2 403 GLN n 
2 404 ARG n 
2 405 ASN n 
2 406 LEU n 
2 407 PRO n 
2 408 PHE n 
2 409 ASP n 
2 410 ARG n 
2 411 PRO n 
2 412 THR n 
2 413 ILE n 
2 414 MET n 
2 415 ALA n 
2 416 ALA n 
2 417 PHE n 
2 418 THR n 
2 419 GLY n 
2 420 ASN n 
2 421 THR n 
2 422 GLU n 
2 423 GLY n 
2 424 ARG n 
2 425 THR n 
2 426 SER n 
2 427 ASP n 
2 428 MET n 
2 429 ARG n 
2 430 THR n 
2 431 GLU n 
2 432 ILE n 
2 433 ILE n 
2 434 ARG n 
2 435 LEU n 
2 436 MET n 
2 437 GLU n 
2 438 SER n 
2 439 ALA n 
2 440 ARG n 
2 441 PRO n 
2 442 GLU n 
2 443 ASP n 
2 444 VAL n 
2 445 SER n 
2 446 PHE n 
2 447 GLN n 
2 448 GLY n 
2 449 ARG n 
2 450 GLY n 
2 451 VAL n 
2 452 PHE n 
2 453 GLU n 
2 454 LEU n 
2 455 SER n 
2 456 ASP n 
2 457 GLU n 
2 458 LYS n 
2 459 ALA n 
2 460 THR n 
2 461 SER n 
2 462 PRO n 
2 463 ILE n 
2 464 VAL n 
2 465 PRO n 
2 466 SER n 
2 467 PHE n 
2 468 ASP n 
2 469 MET n 
2 470 SER n 
2 471 ASN n 
2 472 GLU n 
2 473 GLY n 
2 474 SER n 
2 475 TYR n 
2 476 PHE n 
2 477 PHE n 
2 478 GLY n 
2 479 ASP n 
2 480 ASN n 
2 481 ALA n 
2 482 GLU n 
2 483 GLU n 
2 484 TYR n 
2 485 ASP n 
2 486 ASN n 
2 487 LEU n 
2 488 GLU n 
2 489 HIS n 
2 490 HIS n 
2 491 HIS n 
2 492 HIS n 
2 493 HIS n 
2 494 HIS n 
# 
_entity_src_gen.entity_id                          2 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   494 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 NP 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Influenza A virus' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     11320 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
_pdbx_entity_src_syn.entity_id              1 
_pdbx_entity_src_syn.pdbx_src_id            1 
_pdbx_entity_src_syn.pdbx_alt_source_flag   sample 
_pdbx_entity_src_syn.pdbx_beg_seq_num       1 
_pdbx_entity_src_syn.pdbx_end_seq_num       14 
_pdbx_entity_src_syn.organism_scientific    'synthetic construct' 
_pdbx_entity_src_syn.organism_common_name   ? 
_pdbx_entity_src_syn.ncbi_taxonomy_id       32630 
_pdbx_entity_src_syn.details                ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                     ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE                    ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE                  ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'             ? 'C4 H7 N O4'     133.103 
C   'RNA linking'       y "CYTIDINE-5'-MONOPHOSPHATE" ? 'C9 H14 N3 O8 P' 323.197 
CYS 'L-peptide linking' y CYSTEINE                    ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE                   ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'             ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                     ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE                   ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE                  ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE                     ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                      ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE                  ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE               ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE                     ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                      ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE                   ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                  ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE                    ? 'C9 H11 N O3'    181.189 
U   'RNA linking'       y "URIDINE-5'-MONOPHOSPHATE"  ? 'C9 H13 N2 O9 P' 324.181 
VAL 'L-peptide linking' y VALINE                      ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   U   1   7   ?   ?   ?   C . n 
A 1 2   C   2   8   8   C   C   C . n 
A 1 3   U   3   9   9   U   U   C . n 
A 1 4   C   4   10  10  C   C   C . n 
A 1 5   U   5   11  11  U   U   C . n 
A 1 6   C   6   12  12  C   C   C . n 
A 1 7   U   7   13  13  U   U   C . n 
A 1 8   C   8   14  ?   ?   ?   C . n 
A 1 9   U   9   15  ?   ?   ?   C . n 
A 1 10  C   10  16  ?   ?   ?   C . n 
A 1 11  U   11  17  ?   ?   ?   C . n 
A 1 12  C   12  18  ?   ?   ?   C . n 
A 1 13  U   13  19  ?   ?   ?   C . n 
A 1 14  C   14  20  ?   ?   ?   C . n 
B 1 1   U   1   1   1   U   U   D . n 
B 1 2   C   2   2   2   C   C   D . n 
B 1 3   U   3   3   3   U   U   D . n 
B 1 4   C   4   4   4   C   C   D . n 
B 1 5   U   5   5   5   U   U   D . n 
B 1 6   C   6   6   6   C   C   D . n 
B 1 7   U   7   7   7   U   U   D . n 
B 1 8   C   8   8   ?   ?   ?   D . n 
B 1 9   U   9   9   ?   ?   ?   D . n 
B 1 10  C   10  10  ?   ?   ?   D . n 
B 1 11  U   11  11  ?   ?   ?   D . n 
B 1 12  C   12  12  ?   ?   ?   D . n 
B 1 13  U   13  13  ?   ?   ?   D . n 
B 1 14  C   14  14  ?   ?   ?   D . n 
C 2 1   HIS 1   13  ?   ?   ?   B . n 
C 2 2   MET 2   14  ?   ?   ?   B . n 
C 2 3   THR 3   15  ?   ?   ?   B . n 
C 2 4   ASP 4   16  ?   ?   ?   B . n 
C 2 5   GLY 5   17  ?   ?   ?   B . n 
C 2 6   GLU 6   18  ?   ?   ?   B . n 
C 2 7   ARG 7   19  ?   ?   ?   B . n 
C 2 8   GLN 8   20  ?   ?   ?   B . n 
C 2 9   ASN 9   21  ?   ?   ?   B . n 
C 2 10  ALA 10  22  ?   ?   ?   B . n 
C 2 11  THR 11  23  ?   ?   ?   B . n 
C 2 12  GLU 12  24  ?   ?   ?   B . n 
C 2 13  ILE 13  25  ?   ?   ?   B . n 
C 2 14  ARG 14  26  ?   ?   ?   B . n 
C 2 15  ALA 15  27  ?   ?   ?   B . n 
C 2 16  SER 16  28  ?   ?   ?   B . n 
C 2 17  VAL 17  29  ?   ?   ?   B . n 
C 2 18  GLY 18  30  ?   ?   ?   B . n 
C 2 19  LYS 19  31  ?   ?   ?   B . n 
C 2 20  MET 20  32  ?   ?   ?   B . n 
C 2 21  ILE 21  33  ?   ?   ?   B . n 
C 2 22  ASP 22  34  ?   ?   ?   B . n 
C 2 23  GLY 23  35  ?   ?   ?   B . n 
C 2 24  ILE 24  36  ?   ?   ?   B . n 
C 2 25  GLY 25  37  ?   ?   ?   B . n 
C 2 26  ARG 26  38  ?   ?   ?   B . n 
C 2 27  PHE 27  39  ?   ?   ?   B . n 
C 2 28  TYR 28  40  ?   ?   ?   B . n 
C 2 29  ILE 29  41  ?   ?   ?   B . n 
C 2 30  GLN 30  42  ?   ?   ?   B . n 
C 2 31  MET 31  43  ?   ?   ?   B . n 
C 2 32  CYS 32  44  ?   ?   ?   B . n 
C 2 33  THR 33  45  ?   ?   ?   B . n 
C 2 34  GLU 34  46  ?   ?   ?   B . n 
C 2 35  LEU 35  47  ?   ?   ?   B . n 
C 2 36  LYS 36  48  ?   ?   ?   B . n 
C 2 37  LEU 37  49  ?   ?   ?   B . n 
C 2 38  SER 38  50  ?   ?   ?   B . n 
C 2 39  ASP 39  51  ?   ?   ?   B . n 
C 2 40  TYR 40  52  ?   ?   ?   B . n 
C 2 41  GLU 41  53  ?   ?   ?   B . n 
C 2 42  GLY 42  54  ?   ?   ?   B . n 
C 2 43  ARG 43  55  ?   ?   ?   B . n 
C 2 44  LEU 44  56  ?   ?   ?   B . n 
C 2 45  ILE 45  57  ?   ?   ?   B . n 
C 2 46  GLN 46  58  ?   ?   ?   B . n 
C 2 47  ASN 47  59  ?   ?   ?   B . n 
C 2 48  SER 48  60  ?   ?   ?   B . n 
C 2 49  LEU 49  61  ?   ?   ?   B . n 
C 2 50  THR 50  62  ?   ?   ?   B . n 
C 2 51  ILE 51  63  ?   ?   ?   B . n 
C 2 52  GLU 52  64  ?   ?   ?   B . n 
C 2 53  ARG 53  65  ?   ?   ?   B . n 
C 2 54  MET 54  66  ?   ?   ?   B . n 
C 2 55  VAL 55  67  ?   ?   ?   B . n 
C 2 56  LEU 56  68  ?   ?   ?   B . n 
C 2 57  SER 57  69  ?   ?   ?   B . n 
C 2 58  ALA 58  70  ?   ?   ?   B . n 
C 2 59  PHE 59  71  ?   ?   ?   B . n 
C 2 60  ASP 60  72  ?   ?   ?   B . n 
C 2 61  GLU 61  73  ?   ?   ?   B . n 
C 2 62  ARG 62  74  ?   ?   ?   B . n 
C 2 63  ARG 63  75  ?   ?   ?   B . n 
C 2 64  ASN 64  76  ?   ?   ?   B . n 
C 2 65  LYS 65  77  ?   ?   ?   B . n 
C 2 66  TYR 66  78  ?   ?   ?   B . n 
C 2 67  LEU 67  79  ?   ?   ?   B . n 
C 2 68  GLU 68  80  ?   ?   ?   B . n 
C 2 69  GLU 69  81  ?   ?   ?   B . n 
C 2 70  HIS 70  82  ?   ?   ?   B . n 
C 2 71  PRO 71  83  ?   ?   ?   B . n 
C 2 72  SER 72  84  ?   ?   ?   B . n 
C 2 73  ALA 73  85  ?   ?   ?   B . n 
C 2 74  GLY 74  86  ?   ?   ?   B . n 
C 2 75  LYS 75  87  ?   ?   ?   B . n 
C 2 76  ASP 76  88  ?   ?   ?   B . n 
C 2 77  PRO 77  89  ?   ?   ?   B . n 
C 2 78  LYS 78  90  ?   ?   ?   B . n 
C 2 79  LYS 79  91  ?   ?   ?   B . n 
C 2 80  THR 80  92  ?   ?   ?   B . n 
C 2 81  GLY 81  93  ?   ?   ?   B . n 
C 2 82  GLY 82  94  ?   ?   ?   B . n 
C 2 83  PRO 83  95  ?   ?   ?   B . n 
C 2 84  ILE 84  96  ?   ?   ?   B . n 
C 2 85  TYR 85  97  ?   ?   ?   B . n 
C 2 86  ARG 86  98  ?   ?   ?   B . n 
C 2 87  ARG 87  99  ?   ?   ?   B . n 
C 2 88  VAL 88  100 ?   ?   ?   B . n 
C 2 89  ASP 89  101 ?   ?   ?   B . n 
C 2 90  GLY 90  102 ?   ?   ?   B . n 
C 2 91  LYS 91  103 ?   ?   ?   B . n 
C 2 92  TRP 92  104 ?   ?   ?   B . n 
C 2 93  ARG 93  105 ?   ?   ?   B . n 
C 2 94  ARG 94  106 ?   ?   ?   B . n 
C 2 95  GLU 95  107 ?   ?   ?   B . n 
C 2 96  LEU 96  108 ?   ?   ?   B . n 
C 2 97  ILE 97  109 ?   ?   ?   B . n 
C 2 98  LEU 98  110 ?   ?   ?   B . n 
C 2 99  TYR 99  111 ?   ?   ?   B . n 
C 2 100 ASP 100 112 ?   ?   ?   B . n 
C 2 101 LYS 101 113 ?   ?   ?   B . n 
C 2 102 GLU 102 114 ?   ?   ?   B . n 
C 2 103 GLU 103 115 ?   ?   ?   B . n 
C 2 104 ILE 104 116 ?   ?   ?   B . n 
C 2 105 ARG 105 117 ?   ?   ?   B . n 
C 2 106 ARG 106 118 ?   ?   ?   B . n 
C 2 107 ILE 107 119 ?   ?   ?   B . n 
C 2 108 TRP 108 120 ?   ?   ?   B . n 
C 2 109 ARG 109 121 ?   ?   ?   B . n 
C 2 110 GLN 110 122 ?   ?   ?   B . n 
C 2 111 ALA 111 123 ?   ?   ?   B . n 
C 2 112 ASN 112 124 ?   ?   ?   B . n 
C 2 113 ASN 113 125 ?   ?   ?   B . n 
C 2 114 GLY 114 126 ?   ?   ?   B . n 
C 2 115 ASP 115 127 ?   ?   ?   B . n 
C 2 116 ASP 116 128 ?   ?   ?   B . n 
C 2 117 ALA 117 129 ?   ?   ?   B . n 
C 2 118 THR 118 130 ?   ?   ?   B . n 
C 2 119 ALA 119 131 ?   ?   ?   B . n 
C 2 120 GLY 120 132 ?   ?   ?   B . n 
C 2 121 LEU 121 133 ?   ?   ?   B . n 
C 2 122 THR 122 134 ?   ?   ?   B . n 
C 2 123 HIS 123 135 ?   ?   ?   B . n 
C 2 124 MET 124 136 ?   ?   ?   B . n 
C 2 125 MET 125 137 ?   ?   ?   B . n 
C 2 126 ILE 126 138 ?   ?   ?   B . n 
C 2 127 TRP 127 139 ?   ?   ?   B . n 
C 2 128 HIS 128 140 ?   ?   ?   B . n 
C 2 129 SER 129 141 ?   ?   ?   B . n 
C 2 130 ASN 130 142 ?   ?   ?   B . n 
C 2 131 LEU 131 143 ?   ?   ?   B . n 
C 2 132 ASN 132 144 ?   ?   ?   B . n 
C 2 133 ASP 133 145 ?   ?   ?   B . n 
C 2 134 ALA 134 146 ?   ?   ?   B . n 
C 2 135 THR 135 147 ?   ?   ?   B . n 
C 2 136 TYR 136 148 ?   ?   ?   B . n 
C 2 137 GLN 137 149 ?   ?   ?   B . n 
C 2 138 ARG 138 150 ?   ?   ?   B . n 
C 2 139 THR 139 151 ?   ?   ?   B . n 
C 2 140 ARG 140 152 ?   ?   ?   B . n 
C 2 141 ALA 141 153 ?   ?   ?   B . n 
C 2 142 LEU 142 154 ?   ?   ?   B . n 
C 2 143 VAL 143 155 ?   ?   ?   B . n 
C 2 144 ARG 144 156 ?   ?   ?   B . n 
C 2 145 THR 145 157 ?   ?   ?   B . n 
C 2 146 GLY 146 158 ?   ?   ?   B . n 
C 2 147 MET 147 159 ?   ?   ?   B . n 
C 2 148 ASP 148 160 ?   ?   ?   B . n 
C 2 149 PRO 149 161 ?   ?   ?   B . n 
C 2 150 ARG 150 162 ?   ?   ?   B . n 
C 2 151 MET 151 163 ?   ?   ?   B . n 
C 2 152 CYS 152 164 ?   ?   ?   B . n 
C 2 153 SER 153 165 ?   ?   ?   B . n 
C 2 154 LEU 154 166 ?   ?   ?   B . n 
C 2 155 MET 155 167 ?   ?   ?   B . n 
C 2 156 GLN 156 168 ?   ?   ?   B . n 
C 2 157 GLY 157 169 ?   ?   ?   B . n 
C 2 158 SER 158 170 ?   ?   ?   B . n 
C 2 159 THR 159 171 ?   ?   ?   B . n 
C 2 160 LEU 160 172 ?   ?   ?   B . n 
C 2 161 PRO 161 173 ?   ?   ?   B . n 
C 2 162 ARG 162 174 ?   ?   ?   B . n 
C 2 163 ARG 163 175 ?   ?   ?   B . n 
C 2 164 SER 164 176 ?   ?   ?   B . n 
C 2 165 GLY 165 177 ?   ?   ?   B . n 
C 2 166 ALA 166 178 ?   ?   ?   B . n 
C 2 167 ALA 167 179 ?   ?   ?   B . n 
C 2 168 GLY 168 180 ?   ?   ?   B . n 
C 2 169 ALA 169 181 ?   ?   ?   B . n 
C 2 170 ALA 170 182 ?   ?   ?   B . n 
C 2 171 VAL 171 183 ?   ?   ?   B . n 
C 2 172 LYS 172 184 ?   ?   ?   B . n 
C 2 173 GLY 173 185 ?   ?   ?   B . n 
C 2 174 VAL 174 186 ?   ?   ?   B . n 
C 2 175 GLY 175 187 ?   ?   ?   B . n 
C 2 176 THR 176 188 ?   ?   ?   B . n 
C 2 177 MET 177 189 ?   ?   ?   B . n 
C 2 178 VAL 178 190 ?   ?   ?   B . n 
C 2 179 MET 179 191 ?   ?   ?   B . n 
C 2 180 GLU 180 192 ?   ?   ?   B . n 
C 2 181 LEU 181 193 ?   ?   ?   B . n 
C 2 182 ILE 182 194 ?   ?   ?   B . n 
C 2 183 ARG 183 195 ?   ?   ?   B . n 
C 2 184 MET 184 196 ?   ?   ?   B . n 
C 2 185 ILE 185 197 ?   ?   ?   B . n 
C 2 186 LYS 186 198 ?   ?   ?   B . n 
C 2 187 ARG 187 199 ?   ?   ?   B . n 
C 2 188 GLY 188 200 ?   ?   ?   B . n 
C 2 189 ILE 189 201 ?   ?   ?   B . n 
C 2 190 ASN 190 202 ?   ?   ?   B . n 
C 2 191 ASP 191 203 ?   ?   ?   B . n 
C 2 192 ARG 192 204 ?   ?   ?   B . n 
C 2 193 ASN 193 205 ?   ?   ?   B . n 
C 2 194 PHE 194 206 ?   ?   ?   B . n 
C 2 195 TRP 195 207 ?   ?   ?   B . n 
C 2 196 ARG 196 208 ?   ?   ?   B . n 
C 2 197 GLY 197 209 ?   ?   ?   B . n 
C 2 198 GLU 198 210 ?   ?   ?   B . n 
C 2 199 ASN 199 211 ?   ?   ?   B . n 
C 2 200 GLY 200 212 ?   ?   ?   B . n 
C 2 201 ARG 201 213 ?   ?   ?   B . n 
C 2 202 ARG 202 214 ?   ?   ?   B . n 
C 2 203 THR 203 215 ?   ?   ?   B . n 
C 2 204 ARG 204 216 ?   ?   ?   B . n 
C 2 205 ILE 205 217 ?   ?   ?   B . n 
C 2 206 ALA 206 218 ?   ?   ?   B . n 
C 2 207 TYR 207 219 ?   ?   ?   B . n 
C 2 208 GLU 208 220 ?   ?   ?   B . n 
C 2 209 ARG 209 221 ?   ?   ?   B . n 
C 2 210 MET 210 222 ?   ?   ?   B . n 
C 2 211 CYS 211 223 ?   ?   ?   B . n 
C 2 212 ASN 212 224 ?   ?   ?   B . n 
C 2 213 ILE 213 225 ?   ?   ?   B . n 
C 2 214 LEU 214 226 ?   ?   ?   B . n 
C 2 215 LYS 215 227 ?   ?   ?   B . n 
C 2 216 GLY 216 228 ?   ?   ?   B . n 
C 2 217 LYS 217 229 ?   ?   ?   B . n 
C 2 218 PHE 218 230 ?   ?   ?   B . n 
C 2 219 GLN 219 231 ?   ?   ?   B . n 
C 2 220 THR 220 232 ?   ?   ?   B . n 
C 2 221 ALA 221 233 ?   ?   ?   B . n 
C 2 222 ALA 222 234 ?   ?   ?   B . n 
C 2 223 GLN 223 235 ?   ?   ?   B . n 
C 2 224 ARG 224 236 ?   ?   ?   B . n 
C 2 225 THR 225 237 ?   ?   ?   B . n 
C 2 226 MET 226 238 ?   ?   ?   B . n 
C 2 227 VAL 227 239 ?   ?   ?   B . n 
C 2 228 ASP 228 240 ?   ?   ?   B . n 
C 2 229 GLN 229 241 ?   ?   ?   B . n 
C 2 230 VAL 230 242 ?   ?   ?   B . n 
C 2 231 ARG 231 243 ?   ?   ?   B . n 
C 2 232 GLU 232 244 ?   ?   ?   B . n 
C 2 233 SER 233 245 ?   ?   ?   B . n 
C 2 234 ARG 234 246 ?   ?   ?   B . n 
C 2 235 ASN 235 247 ?   ?   ?   B . n 
C 2 236 PRO 236 248 ?   ?   ?   B . n 
C 2 237 GLY 237 249 ?   ?   ?   B . n 
C 2 238 ASN 238 250 ?   ?   ?   B . n 
C 2 239 ALA 239 251 ?   ?   ?   B . n 
C 2 240 GLU 240 252 ?   ?   ?   B . n 
C 2 241 PHE 241 253 ?   ?   ?   B . n 
C 2 242 GLU 242 254 ?   ?   ?   B . n 
C 2 243 ASP 243 255 ?   ?   ?   B . n 
C 2 244 LEU 244 256 ?   ?   ?   B . n 
C 2 245 ILE 245 257 ?   ?   ?   B . n 
C 2 246 PHE 246 258 ?   ?   ?   B . n 
C 2 247 LEU 247 259 ?   ?   ?   B . n 
C 2 248 ALA 248 260 ?   ?   ?   B . n 
C 2 249 ARG 249 261 ?   ?   ?   B . n 
C 2 250 SER 250 262 ?   ?   ?   B . n 
C 2 251 ALA 251 263 ?   ?   ?   B . n 
C 2 252 LEU 252 264 ?   ?   ?   B . n 
C 2 253 ILE 253 265 ?   ?   ?   B . n 
C 2 254 LEU 254 266 ?   ?   ?   B . n 
C 2 255 ARG 255 267 ?   ?   ?   B . n 
C 2 256 GLY 256 268 ?   ?   ?   B . n 
C 2 257 SER 257 269 ?   ?   ?   B . n 
C 2 258 VAL 258 270 ?   ?   ?   B . n 
C 2 259 ALA 259 271 ?   ?   ?   B . n 
C 2 260 HIS 260 272 ?   ?   ?   B . n 
C 2 261 LYS 261 273 ?   ?   ?   B . n 
C 2 262 SER 262 274 ?   ?   ?   B . n 
C 2 263 CYS 263 275 ?   ?   ?   B . n 
C 2 264 LEU 264 276 ?   ?   ?   B . n 
C 2 265 PRO 265 277 ?   ?   ?   B . n 
C 2 266 ALA 266 278 ?   ?   ?   B . n 
C 2 267 CYS 267 279 ?   ?   ?   B . n 
C 2 268 VAL 268 280 ?   ?   ?   B . n 
C 2 269 TYR 269 281 ?   ?   ?   B . n 
C 2 270 GLY 270 282 ?   ?   ?   B . n 
C 2 271 SER 271 283 ?   ?   ?   B . n 
C 2 272 ALA 272 284 ?   ?   ?   B . n 
C 2 273 VAL 273 285 ?   ?   ?   B . n 
C 2 274 ALA 274 286 ?   ?   ?   B . n 
C 2 275 SER 275 287 ?   ?   ?   B . n 
C 2 276 GLY 276 288 ?   ?   ?   B . n 
C 2 277 TYR 277 289 ?   ?   ?   B . n 
C 2 278 ASP 278 290 ?   ?   ?   B . n 
C 2 279 PHE 279 291 ?   ?   ?   B . n 
C 2 280 GLU 280 292 ?   ?   ?   B . n 
C 2 281 ARG 281 293 ?   ?   ?   B . n 
C 2 282 GLU 282 294 ?   ?   ?   B . n 
C 2 283 GLY 283 295 ?   ?   ?   B . n 
C 2 284 TYR 284 296 ?   ?   ?   B . n 
C 2 285 SER 285 297 ?   ?   ?   B . n 
C 2 286 LEU 286 298 ?   ?   ?   B . n 
C 2 287 VAL 287 299 ?   ?   ?   B . n 
C 2 288 GLY 288 300 ?   ?   ?   B . n 
C 2 289 ILE 289 301 ?   ?   ?   B . n 
C 2 290 ASP 290 302 ?   ?   ?   B . n 
C 2 291 PRO 291 303 ?   ?   ?   B . n 
C 2 292 PHE 292 304 ?   ?   ?   B . n 
C 2 293 ARG 293 305 ?   ?   ?   B . n 
C 2 294 LEU 294 306 ?   ?   ?   B . n 
C 2 295 LEU 295 307 ?   ?   ?   B . n 
C 2 296 GLN 296 308 ?   ?   ?   B . n 
C 2 297 ASN 297 309 ?   ?   ?   B . n 
C 2 298 SER 298 310 ?   ?   ?   B . n 
C 2 299 GLN 299 311 ?   ?   ?   B . n 
C 2 300 VAL 300 312 ?   ?   ?   B . n 
C 2 301 TYR 301 313 ?   ?   ?   B . n 
C 2 302 SER 302 314 ?   ?   ?   B . n 
C 2 303 LEU 303 315 ?   ?   ?   B . n 
C 2 304 ILE 304 316 ?   ?   ?   B . n 
C 2 305 ARG 305 317 ?   ?   ?   B . n 
C 2 306 PRO 306 318 ?   ?   ?   B . n 
C 2 307 ASN 307 319 ?   ?   ?   B . n 
C 2 308 GLU 308 320 ?   ?   ?   B . n 
C 2 309 ASN 309 321 ?   ?   ?   B . n 
C 2 310 PRO 310 322 ?   ?   ?   B . n 
C 2 311 ALA 311 323 ?   ?   ?   B . n 
C 2 312 HIS 312 324 ?   ?   ?   B . n 
C 2 313 LYS 313 325 ?   ?   ?   B . n 
C 2 314 SER 314 326 ?   ?   ?   B . n 
C 2 315 GLN 315 327 ?   ?   ?   B . n 
C 2 316 LEU 316 328 ?   ?   ?   B . n 
C 2 317 VAL 317 329 ?   ?   ?   B . n 
C 2 318 TRP 318 330 ?   ?   ?   B . n 
C 2 319 MET 319 331 ?   ?   ?   B . n 
C 2 320 ALA 320 332 ?   ?   ?   B . n 
C 2 321 CYS 321 333 ?   ?   ?   B . n 
C 2 322 HIS 322 334 ?   ?   ?   B . n 
C 2 323 SER 323 335 ?   ?   ?   B . n 
C 2 324 ALA 324 336 ?   ?   ?   B . n 
C 2 325 ALA 325 337 ?   ?   ?   B . n 
C 2 326 PHE 326 338 ?   ?   ?   B . n 
C 2 327 GLU 327 339 ?   ?   ?   B . n 
C 2 328 ASP 328 340 ?   ?   ?   B . n 
C 2 329 LEU 329 341 ?   ?   ?   B . n 
C 2 330 ARG 330 342 ?   ?   ?   B . n 
C 2 331 VAL 331 343 ?   ?   ?   B . n 
C 2 332 SER 332 344 ?   ?   ?   B . n 
C 2 333 SER 333 345 ?   ?   ?   B . n 
C 2 334 PHE 334 346 ?   ?   ?   B . n 
C 2 335 ILE 335 347 ?   ?   ?   B . n 
C 2 336 ARG 336 348 ?   ?   ?   B . n 
C 2 337 GLY 337 349 ?   ?   ?   B . n 
C 2 338 THR 338 350 ?   ?   ?   B . n 
C 2 339 LYS 339 351 ?   ?   ?   B . n 
C 2 340 VAL 340 352 ?   ?   ?   B . n 
C 2 341 VAL 341 353 ?   ?   ?   B . n 
C 2 342 PRO 342 354 ?   ?   ?   B . n 
C 2 343 ARG 343 355 ?   ?   ?   B . n 
C 2 344 GLY 344 356 ?   ?   ?   B . n 
C 2 345 LYS 345 357 ?   ?   ?   B . n 
C 2 346 LEU 346 358 ?   ?   ?   B . n 
C 2 347 SER 347 359 ?   ?   ?   B . n 
C 2 348 THR 348 360 ?   ?   ?   B . n 
C 2 349 ARG 349 361 ?   ?   ?   B . n 
C 2 350 GLY 350 362 ?   ?   ?   B . n 
C 2 351 VAL 351 363 ?   ?   ?   B . n 
C 2 352 GLN 352 364 ?   ?   ?   B . n 
C 2 353 ILE 353 365 ?   ?   ?   B . n 
C 2 354 ALA 354 366 ?   ?   ?   B . n 
C 2 355 SER 355 367 ?   ?   ?   B . n 
C 2 356 ASN 356 368 ?   ?   ?   B . n 
C 2 357 GLU 357 369 ?   ?   ?   B . n 
C 2 358 ASN 358 370 ?   ?   ?   B . n 
C 2 359 MET 359 371 ?   ?   ?   B . n 
C 2 360 GLU 360 372 ?   ?   ?   B . n 
C 2 361 THR 361 373 ?   ?   ?   B . n 
C 2 362 MET 362 374 ?   ?   ?   B . n 
C 2 363 GLU 363 375 ?   ?   ?   B . n 
C 2 364 SER 364 376 ?   ?   ?   B . n 
C 2 365 SER 365 377 ?   ?   ?   B . n 
C 2 366 THR 366 378 ?   ?   ?   B . n 
C 2 367 LEU 367 379 ?   ?   ?   B . n 
C 2 368 GLU 368 380 ?   ?   ?   B . n 
C 2 369 LEU 369 381 ?   ?   ?   B . n 
C 2 370 ARG 370 382 ?   ?   ?   B . n 
C 2 371 SER 371 383 ?   ?   ?   B . n 
C 2 372 ARG 372 384 ?   ?   ?   B . n 
C 2 373 TYR 373 385 ?   ?   ?   B . n 
C 2 374 TRP 374 386 ?   ?   ?   B . n 
C 2 375 ALA 375 387 ?   ?   ?   B . n 
C 2 376 ILE 376 388 ?   ?   ?   B . n 
C 2 377 ARG 377 389 ?   ?   ?   B . n 
C 2 378 THR 378 390 ?   ?   ?   B . n 
C 2 379 ARG 379 391 ?   ?   ?   B . n 
C 2 380 SER 380 392 ?   ?   ?   B . n 
C 2 381 GLY 381 393 ?   ?   ?   B . n 
C 2 382 GLY 382 394 ?   ?   ?   B . n 
C 2 383 ASN 383 395 ?   ?   ?   B . n 
C 2 384 THR 384 396 ?   ?   ?   B . n 
C 2 385 ASN 385 397 ?   ?   ?   B . n 
C 2 386 GLN 386 398 ?   ?   ?   B . n 
C 2 387 GLN 387 399 ?   ?   ?   B . n 
C 2 388 ARG 388 400 ?   ?   ?   B . n 
C 2 389 ALA 389 401 ?   ?   ?   B . n 
C 2 390 SER 390 402 ?   ?   ?   B . n 
C 2 391 SER 391 403 403 SER SER B . n 
C 2 392 GLY 392 404 404 GLY GLY B . n 
C 2 393 GLN 393 405 405 GLN GLN B . n 
C 2 394 ILE 394 406 406 ILE ILE B . n 
C 2 395 SER 395 407 407 SER SER B . n 
C 2 396 ILE 396 408 408 ILE ILE B . n 
C 2 397 GLN 397 409 409 GLN GLN B . n 
C 2 398 PRO 398 410 410 PRO PRO B . n 
C 2 399 THR 399 411 411 THR THR B . n 
C 2 400 PHE 400 412 412 PHE PHE B . n 
C 2 401 SER 401 413 413 SER SER B . n 
C 2 402 VAL 402 414 414 VAL VAL B . n 
C 2 403 GLN 403 415 415 GLN GLN B . n 
C 2 404 ARG 404 416 416 ARG ARG B . n 
C 2 405 ASN 405 417 417 ASN ASN B . n 
C 2 406 LEU 406 418 418 LEU LEU B . n 
C 2 407 PRO 407 419 419 PRO PRO B . n 
C 2 408 PHE 408 420 420 PHE PHE B . n 
C 2 409 ASP 409 421 421 ASP ASP B . n 
C 2 410 ARG 410 422 422 ARG ARG B . n 
C 2 411 PRO 411 423 423 PRO PRO B . n 
C 2 412 THR 412 424 424 THR THR B . n 
C 2 413 ILE 413 425 425 ILE ILE B . n 
C 2 414 MET 414 426 426 MET MET B . n 
C 2 415 ALA 415 427 427 ALA ALA B . n 
C 2 416 ALA 416 428 428 ALA ALA B . n 
C 2 417 PHE 417 429 ?   ?   ?   B . n 
C 2 418 THR 418 430 ?   ?   ?   B . n 
C 2 419 GLY 419 431 ?   ?   ?   B . n 
C 2 420 ASN 420 432 ?   ?   ?   B . n 
C 2 421 THR 421 433 ?   ?   ?   B . n 
C 2 422 GLU 422 434 ?   ?   ?   B . n 
C 2 423 GLY 423 435 ?   ?   ?   B . n 
C 2 424 ARG 424 436 ?   ?   ?   B . n 
C 2 425 THR 425 437 ?   ?   ?   B . n 
C 2 426 SER 426 438 ?   ?   ?   B . n 
C 2 427 ASP 427 439 ?   ?   ?   B . n 
C 2 428 MET 428 440 ?   ?   ?   B . n 
C 2 429 ARG 429 441 ?   ?   ?   B . n 
C 2 430 THR 430 442 ?   ?   ?   B . n 
C 2 431 GLU 431 443 ?   ?   ?   B . n 
C 2 432 ILE 432 444 ?   ?   ?   B . n 
C 2 433 ILE 433 445 ?   ?   ?   B . n 
C 2 434 ARG 434 446 ?   ?   ?   B . n 
C 2 435 LEU 435 447 ?   ?   ?   B . n 
C 2 436 MET 436 448 ?   ?   ?   B . n 
C 2 437 GLU 437 449 ?   ?   ?   B . n 
C 2 438 SER 438 450 ?   ?   ?   B . n 
C 2 439 ALA 439 451 ?   ?   ?   B . n 
C 2 440 ARG 440 452 ?   ?   ?   B . n 
C 2 441 PRO 441 453 ?   ?   ?   B . n 
C 2 442 GLU 442 454 ?   ?   ?   B . n 
C 2 443 ASP 443 455 ?   ?   ?   B . n 
C 2 444 VAL 444 456 ?   ?   ?   B . n 
C 2 445 SER 445 457 ?   ?   ?   B . n 
C 2 446 PHE 446 458 ?   ?   ?   B . n 
C 2 447 GLN 447 459 ?   ?   ?   B . n 
C 2 448 GLY 448 460 ?   ?   ?   B . n 
C 2 449 ARG 449 461 ?   ?   ?   B . n 
C 2 450 GLY 450 462 ?   ?   ?   B . n 
C 2 451 VAL 451 463 ?   ?   ?   B . n 
C 2 452 PHE 452 464 ?   ?   ?   B . n 
C 2 453 GLU 453 465 ?   ?   ?   B . n 
C 2 454 LEU 454 466 ?   ?   ?   B . n 
C 2 455 SER 455 467 ?   ?   ?   B . n 
C 2 456 ASP 456 468 ?   ?   ?   B . n 
C 2 457 GLU 457 469 ?   ?   ?   B . n 
C 2 458 LYS 458 470 ?   ?   ?   B . n 
C 2 459 ALA 459 471 ?   ?   ?   B . n 
C 2 460 THR 460 472 ?   ?   ?   B . n 
C 2 461 SER 461 473 ?   ?   ?   B . n 
C 2 462 PRO 462 474 ?   ?   ?   B . n 
C 2 463 ILE 463 475 ?   ?   ?   B . n 
C 2 464 VAL 464 476 ?   ?   ?   B . n 
C 2 465 PRO 465 477 ?   ?   ?   B . n 
C 2 466 SER 466 478 ?   ?   ?   B . n 
C 2 467 PHE 467 479 ?   ?   ?   B . n 
C 2 468 ASP 468 480 ?   ?   ?   B . n 
C 2 469 MET 469 481 ?   ?   ?   B . n 
C 2 470 SER 470 482 ?   ?   ?   B . n 
C 2 471 ASN 471 483 ?   ?   ?   B . n 
C 2 472 GLU 472 484 ?   ?   ?   B . n 
C 2 473 GLY 473 485 ?   ?   ?   B . n 
C 2 474 SER 474 486 ?   ?   ?   B . n 
C 2 475 TYR 475 487 ?   ?   ?   B . n 
C 2 476 PHE 476 488 ?   ?   ?   B . n 
C 2 477 PHE 477 489 ?   ?   ?   B . n 
C 2 478 GLY 478 490 ?   ?   ?   B . n 
C 2 479 ASP 479 491 ?   ?   ?   B . n 
C 2 480 ASN 480 492 ?   ?   ?   B . n 
C 2 481 ALA 481 493 ?   ?   ?   B . n 
C 2 482 GLU 482 494 ?   ?   ?   B . n 
C 2 483 GLU 483 495 ?   ?   ?   B . n 
C 2 484 TYR 484 496 ?   ?   ?   B . n 
C 2 485 ASP 485 497 ?   ?   ?   B . n 
C 2 486 ASN 486 498 ?   ?   ?   B . n 
C 2 487 LEU 487 499 ?   ?   ?   B . n 
C 2 488 GLU 488 500 ?   ?   ?   B . n 
C 2 489 HIS 489 501 ?   ?   ?   B . n 
C 2 490 HIS 490 502 ?   ?   ?   B . n 
C 2 491 HIS 491 503 ?   ?   ?   B . n 
C 2 492 HIS 492 504 ?   ?   ?   B . n 
C 2 493 HIS 493 505 ?   ?   ?   B . n 
C 2 494 HIS 494 506 ?   ?   ?   B . n 
D 2 1   HIS 1   13  ?   ?   ?   A . n 
D 2 2   MET 2   14  ?   ?   ?   A . n 
D 2 3   THR 3   15  ?   ?   ?   A . n 
D 2 4   ASP 4   16  16  ASP ASP A . n 
D 2 5   GLY 5   17  17  GLY GLY A . n 
D 2 6   GLU 6   18  18  GLU GLU A . n 
D 2 7   ARG 7   19  19  ARG ARG A . n 
D 2 8   GLN 8   20  20  GLN GLN A . n 
D 2 9   ASN 9   21  21  ASN ASN A . n 
D 2 10  ALA 10  22  22  ALA ALA A . n 
D 2 11  THR 11  23  23  THR THR A . n 
D 2 12  GLU 12  24  24  GLU GLU A . n 
D 2 13  ILE 13  25  25  ILE ILE A . n 
D 2 14  ARG 14  26  26  ARG ARG A . n 
D 2 15  ALA 15  27  27  ALA ALA A . n 
D 2 16  SER 16  28  28  SER SER A . n 
D 2 17  VAL 17  29  29  VAL VAL A . n 
D 2 18  GLY 18  30  30  GLY GLY A . n 
D 2 19  LYS 19  31  31  LYS LYS A . n 
D 2 20  MET 20  32  32  MET MET A . n 
D 2 21  ILE 21  33  33  ILE ILE A . n 
D 2 22  ASP 22  34  34  ASP ASP A . n 
D 2 23  GLY 23  35  35  GLY GLY A . n 
D 2 24  ILE 24  36  36  ILE ILE A . n 
D 2 25  GLY 25  37  37  GLY GLY A . n 
D 2 26  ARG 26  38  38  ARG ARG A . n 
D 2 27  PHE 27  39  39  PHE PHE A . n 
D 2 28  TYR 28  40  40  TYR TYR A . n 
D 2 29  ILE 29  41  41  ILE ILE A . n 
D 2 30  GLN 30  42  42  GLN GLN A . n 
D 2 31  MET 31  43  43  MET MET A . n 
D 2 32  CYS 32  44  44  CYS CYS A . n 
D 2 33  THR 33  45  45  THR THR A . n 
D 2 34  GLU 34  46  46  GLU GLU A . n 
D 2 35  LEU 35  47  47  LEU LEU A . n 
D 2 36  LYS 36  48  48  LYS LYS A . n 
D 2 37  LEU 37  49  49  LEU LEU A . n 
D 2 38  SER 38  50  50  SER SER A . n 
D 2 39  ASP 39  51  51  ASP ASP A . n 
D 2 40  TYR 40  52  52  TYR TYR A . n 
D 2 41  GLU 41  53  53  GLU GLU A . n 
D 2 42  GLY 42  54  54  GLY GLY A . n 
D 2 43  ARG 43  55  55  ARG ARG A . n 
D 2 44  LEU 44  56  56  LEU LEU A . n 
D 2 45  ILE 45  57  57  ILE ILE A . n 
D 2 46  GLN 46  58  58  GLN GLN A . n 
D 2 47  ASN 47  59  59  ASN ASN A . n 
D 2 48  SER 48  60  60  SER SER A . n 
D 2 49  LEU 49  61  61  LEU LEU A . n 
D 2 50  THR 50  62  62  THR THR A . n 
D 2 51  ILE 51  63  63  ILE ILE A . n 
D 2 52  GLU 52  64  64  GLU GLU A . n 
D 2 53  ARG 53  65  65  ARG ARG A . n 
D 2 54  MET 54  66  66  MET MET A . n 
D 2 55  VAL 55  67  67  VAL VAL A . n 
D 2 56  LEU 56  68  68  LEU LEU A . n 
D 2 57  SER 57  69  69  SER SER A . n 
D 2 58  ALA 58  70  70  ALA ALA A . n 
D 2 59  PHE 59  71  71  PHE PHE A . n 
D 2 60  ASP 60  72  72  ASP ASP A . n 
D 2 61  GLU 61  73  73  GLU GLU A . n 
D 2 62  ARG 62  74  74  ARG ARG A . n 
D 2 63  ARG 63  75  75  ARG ARG A . n 
D 2 64  ASN 64  76  76  ASN ASN A . n 
D 2 65  LYS 65  77  77  LYS LYS A . n 
D 2 66  TYR 66  78  78  TYR TYR A . n 
D 2 67  LEU 67  79  79  LEU LEU A . n 
D 2 68  GLU 68  80  80  GLU GLU A . n 
D 2 69  GLU 69  81  81  GLU GLU A . n 
D 2 70  HIS 70  82  82  HIS HIS A . n 
D 2 71  PRO 71  83  83  PRO PRO A . n 
D 2 72  SER 72  84  84  SER SER A . n 
D 2 73  ALA 73  85  85  ALA ALA A . n 
D 2 74  GLY 74  86  86  GLY GLY A . n 
D 2 75  LYS 75  87  87  LYS LYS A . n 
D 2 76  ASP 76  88  88  ASP ASP A . n 
D 2 77  PRO 77  89  89  PRO PRO A . n 
D 2 78  LYS 78  90  90  LYS LYS A . n 
D 2 79  LYS 79  91  91  LYS LYS A . n 
D 2 80  THR 80  92  92  THR THR A . n 
D 2 81  GLY 81  93  93  GLY GLY A . n 
D 2 82  GLY 82  94  94  GLY GLY A . n 
D 2 83  PRO 83  95  95  PRO PRO A . n 
D 2 84  ILE 84  96  96  ILE ILE A . n 
D 2 85  TYR 85  97  97  TYR TYR A . n 
D 2 86  ARG 86  98  98  ARG ARG A . n 
D 2 87  ARG 87  99  99  ARG ARG A . n 
D 2 88  VAL 88  100 100 VAL VAL A . n 
D 2 89  ASP 89  101 101 ASP ASP A . n 
D 2 90  GLY 90  102 102 GLY GLY A . n 
D 2 91  LYS 91  103 103 LYS LYS A . n 
D 2 92  TRP 92  104 104 TRP TRP A . n 
D 2 93  ARG 93  105 105 ARG ARG A . n 
D 2 94  ARG 94  106 106 ARG ARG A . n 
D 2 95  GLU 95  107 107 GLU GLU A . n 
D 2 96  LEU 96  108 108 LEU LEU A . n 
D 2 97  ILE 97  109 109 ILE ILE A . n 
D 2 98  LEU 98  110 110 LEU LEU A . n 
D 2 99  TYR 99  111 111 TYR TYR A . n 
D 2 100 ASP 100 112 112 ASP ASP A . n 
D 2 101 LYS 101 113 113 LYS LYS A . n 
D 2 102 GLU 102 114 114 GLU GLU A . n 
D 2 103 GLU 103 115 115 GLU GLU A . n 
D 2 104 ILE 104 116 116 ILE ILE A . n 
D 2 105 ARG 105 117 117 ARG ARG A . n 
D 2 106 ARG 106 118 118 ARG ARG A . n 
D 2 107 ILE 107 119 119 ILE ILE A . n 
D 2 108 TRP 108 120 120 TRP TRP A . n 
D 2 109 ARG 109 121 121 ARG ARG A . n 
D 2 110 GLN 110 122 122 GLN GLN A . n 
D 2 111 ALA 111 123 123 ALA ALA A . n 
D 2 112 ASN 112 124 124 ASN ASN A . n 
D 2 113 ASN 113 125 125 ASN ASN A . n 
D 2 114 GLY 114 126 126 GLY GLY A . n 
D 2 115 ASP 115 127 127 ASP ASP A . n 
D 2 116 ASP 116 128 128 ASP ASP A . n 
D 2 117 ALA 117 129 129 ALA ALA A . n 
D 2 118 THR 118 130 130 THR THR A . n 
D 2 119 ALA 119 131 131 ALA ALA A . n 
D 2 120 GLY 120 132 132 GLY GLY A . n 
D 2 121 LEU 121 133 133 LEU LEU A . n 
D 2 122 THR 122 134 134 THR THR A . n 
D 2 123 HIS 123 135 135 HIS HIS A . n 
D 2 124 MET 124 136 136 MET MET A . n 
D 2 125 MET 125 137 137 MET MET A . n 
D 2 126 ILE 126 138 138 ILE ILE A . n 
D 2 127 TRP 127 139 139 TRP TRP A . n 
D 2 128 HIS 128 140 140 HIS HIS A . n 
D 2 129 SER 129 141 141 SER SER A . n 
D 2 130 ASN 130 142 142 ASN ASN A . n 
D 2 131 LEU 131 143 143 LEU LEU A . n 
D 2 132 ASN 132 144 144 ASN ASN A . n 
D 2 133 ASP 133 145 145 ASP ASP A . n 
D 2 134 ALA 134 146 146 ALA ALA A . n 
D 2 135 THR 135 147 147 THR THR A . n 
D 2 136 TYR 136 148 148 TYR TYR A . n 
D 2 137 GLN 137 149 149 GLN GLN A . n 
D 2 138 ARG 138 150 150 ARG ARG A . n 
D 2 139 THR 139 151 151 THR THR A . n 
D 2 140 ARG 140 152 152 ARG ARG A . n 
D 2 141 ALA 141 153 153 ALA ALA A . n 
D 2 142 LEU 142 154 154 LEU LEU A . n 
D 2 143 VAL 143 155 155 VAL VAL A . n 
D 2 144 ARG 144 156 156 ARG ARG A . n 
D 2 145 THR 145 157 157 THR THR A . n 
D 2 146 GLY 146 158 158 GLY GLY A . n 
D 2 147 MET 147 159 159 MET MET A . n 
D 2 148 ASP 148 160 160 ASP ASP A . n 
D 2 149 PRO 149 161 161 PRO PRO A . n 
D 2 150 ARG 150 162 162 ARG ARG A . n 
D 2 151 MET 151 163 163 MET MET A . n 
D 2 152 CYS 152 164 164 CYS CYS A . n 
D 2 153 SER 153 165 165 SER SER A . n 
D 2 154 LEU 154 166 166 LEU LEU A . n 
D 2 155 MET 155 167 167 MET MET A . n 
D 2 156 GLN 156 168 168 GLN GLN A . n 
D 2 157 GLY 157 169 169 GLY GLY A . n 
D 2 158 SER 158 170 170 SER SER A . n 
D 2 159 THR 159 171 171 THR THR A . n 
D 2 160 LEU 160 172 172 LEU LEU A . n 
D 2 161 PRO 161 173 173 PRO PRO A . n 
D 2 162 ARG 162 174 174 ARG ARG A . n 
D 2 163 ARG 163 175 175 ARG ARG A . n 
D 2 164 SER 164 176 176 SER SER A . n 
D 2 165 GLY 165 177 177 GLY GLY A . n 
D 2 166 ALA 166 178 178 ALA ALA A . n 
D 2 167 ALA 167 179 179 ALA ALA A . n 
D 2 168 GLY 168 180 180 GLY GLY A . n 
D 2 169 ALA 169 181 181 ALA ALA A . n 
D 2 170 ALA 170 182 182 ALA ALA A . n 
D 2 171 VAL 171 183 183 VAL VAL A . n 
D 2 172 LYS 172 184 184 LYS LYS A . n 
D 2 173 GLY 173 185 185 GLY GLY A . n 
D 2 174 VAL 174 186 186 VAL VAL A . n 
D 2 175 GLY 175 187 187 GLY GLY A . n 
D 2 176 THR 176 188 188 THR THR A . n 
D 2 177 MET 177 189 189 MET MET A . n 
D 2 178 VAL 178 190 190 VAL VAL A . n 
D 2 179 MET 179 191 191 MET MET A . n 
D 2 180 GLU 180 192 192 GLU GLU A . n 
D 2 181 LEU 181 193 193 LEU LEU A . n 
D 2 182 ILE 182 194 194 ILE ILE A . n 
D 2 183 ARG 183 195 195 ARG ARG A . n 
D 2 184 MET 184 196 196 MET MET A . n 
D 2 185 ILE 185 197 197 ILE ILE A . n 
D 2 186 LYS 186 198 198 LYS LYS A . n 
D 2 187 ARG 187 199 199 ARG ARG A . n 
D 2 188 GLY 188 200 200 GLY GLY A . n 
D 2 189 ILE 189 201 201 ILE ILE A . n 
D 2 190 ASN 190 202 202 ASN ASN A . n 
D 2 191 ASP 191 203 203 ASP ASP A . n 
D 2 192 ARG 192 204 204 ARG ARG A . n 
D 2 193 ASN 193 205 205 ASN ASN A . n 
D 2 194 PHE 194 206 206 PHE PHE A . n 
D 2 195 TRP 195 207 207 TRP TRP A . n 
D 2 196 ARG 196 208 208 ARG ARG A . n 
D 2 197 GLY 197 209 209 GLY GLY A . n 
D 2 198 GLU 198 210 210 GLU GLU A . n 
D 2 199 ASN 199 211 211 ASN ASN A . n 
D 2 200 GLY 200 212 212 GLY GLY A . n 
D 2 201 ARG 201 213 213 ARG ARG A . n 
D 2 202 ARG 202 214 214 ARG ARG A . n 
D 2 203 THR 203 215 215 THR THR A . n 
D 2 204 ARG 204 216 216 ARG ARG A . n 
D 2 205 ILE 205 217 217 ILE ILE A . n 
D 2 206 ALA 206 218 218 ALA ALA A . n 
D 2 207 TYR 207 219 219 TYR TYR A . n 
D 2 208 GLU 208 220 220 GLU GLU A . n 
D 2 209 ARG 209 221 221 ARG ARG A . n 
D 2 210 MET 210 222 222 MET MET A . n 
D 2 211 CYS 211 223 223 CYS CYS A . n 
D 2 212 ASN 212 224 224 ASN ASN A . n 
D 2 213 ILE 213 225 225 ILE ILE A . n 
D 2 214 LEU 214 226 226 LEU LEU A . n 
D 2 215 LYS 215 227 227 LYS LYS A . n 
D 2 216 GLY 216 228 228 GLY GLY A . n 
D 2 217 LYS 217 229 229 LYS LYS A . n 
D 2 218 PHE 218 230 230 PHE PHE A . n 
D 2 219 GLN 219 231 231 GLN GLN A . n 
D 2 220 THR 220 232 232 THR THR A . n 
D 2 221 ALA 221 233 233 ALA ALA A . n 
D 2 222 ALA 222 234 234 ALA ALA A . n 
D 2 223 GLN 223 235 235 GLN GLN A . n 
D 2 224 ARG 224 236 236 ARG ARG A . n 
D 2 225 THR 225 237 237 THR THR A . n 
D 2 226 MET 226 238 238 MET MET A . n 
D 2 227 VAL 227 239 239 VAL VAL A . n 
D 2 228 ASP 228 240 240 ASP ASP A . n 
D 2 229 GLN 229 241 241 GLN GLN A . n 
D 2 230 VAL 230 242 242 VAL VAL A . n 
D 2 231 ARG 231 243 243 ARG ARG A . n 
D 2 232 GLU 232 244 244 GLU GLU A . n 
D 2 233 SER 233 245 245 SER SER A . n 
D 2 234 ARG 234 246 246 ARG ARG A . n 
D 2 235 ASN 235 247 247 ASN ASN A . n 
D 2 236 PRO 236 248 248 PRO PRO A . n 
D 2 237 GLY 237 249 249 GLY GLY A . n 
D 2 238 ASN 238 250 250 ASN ASN A . n 
D 2 239 ALA 239 251 251 ALA ALA A . n 
D 2 240 GLU 240 252 252 GLU GLU A . n 
D 2 241 PHE 241 253 253 PHE PHE A . n 
D 2 242 GLU 242 254 254 GLU GLU A . n 
D 2 243 ASP 243 255 255 ASP ASP A . n 
D 2 244 LEU 244 256 256 LEU LEU A . n 
D 2 245 ILE 245 257 257 ILE ILE A . n 
D 2 246 PHE 246 258 258 PHE PHE A . n 
D 2 247 LEU 247 259 259 LEU LEU A . n 
D 2 248 ALA 248 260 260 ALA ALA A . n 
D 2 249 ARG 249 261 261 ARG ARG A . n 
D 2 250 SER 250 262 262 SER SER A . n 
D 2 251 ALA 251 263 263 ALA ALA A . n 
D 2 252 LEU 252 264 264 LEU LEU A . n 
D 2 253 ILE 253 265 265 ILE ILE A . n 
D 2 254 LEU 254 266 266 LEU LEU A . n 
D 2 255 ARG 255 267 267 ARG ARG A . n 
D 2 256 GLY 256 268 268 GLY GLY A . n 
D 2 257 SER 257 269 269 SER SER A . n 
D 2 258 VAL 258 270 270 VAL VAL A . n 
D 2 259 ALA 259 271 271 ALA ALA A . n 
D 2 260 HIS 260 272 272 HIS HIS A . n 
D 2 261 LYS 261 273 273 LYS LYS A . n 
D 2 262 SER 262 274 274 SER SER A . n 
D 2 263 CYS 263 275 275 CYS CYS A . n 
D 2 264 LEU 264 276 276 LEU LEU A . n 
D 2 265 PRO 265 277 277 PRO PRO A . n 
D 2 266 ALA 266 278 278 ALA ALA A . n 
D 2 267 CYS 267 279 279 CYS CYS A . n 
D 2 268 VAL 268 280 280 VAL VAL A . n 
D 2 269 TYR 269 281 281 TYR TYR A . n 
D 2 270 GLY 270 282 282 GLY GLY A . n 
D 2 271 SER 271 283 283 SER SER A . n 
D 2 272 ALA 272 284 284 ALA ALA A . n 
D 2 273 VAL 273 285 285 VAL VAL A . n 
D 2 274 ALA 274 286 286 ALA ALA A . n 
D 2 275 SER 275 287 287 SER SER A . n 
D 2 276 GLY 276 288 288 GLY GLY A . n 
D 2 277 TYR 277 289 289 TYR TYR A . n 
D 2 278 ASP 278 290 290 ASP ASP A . n 
D 2 279 PHE 279 291 291 PHE PHE A . n 
D 2 280 GLU 280 292 292 GLU GLU A . n 
D 2 281 ARG 281 293 293 ARG ARG A . n 
D 2 282 GLU 282 294 294 GLU GLU A . n 
D 2 283 GLY 283 295 295 GLY GLY A . n 
D 2 284 TYR 284 296 296 TYR TYR A . n 
D 2 285 SER 285 297 297 SER SER A . n 
D 2 286 LEU 286 298 298 LEU LEU A . n 
D 2 287 VAL 287 299 299 VAL VAL A . n 
D 2 288 GLY 288 300 300 GLY GLY A . n 
D 2 289 ILE 289 301 301 ILE ILE A . n 
D 2 290 ASP 290 302 302 ASP ASP A . n 
D 2 291 PRO 291 303 303 PRO PRO A . n 
D 2 292 PHE 292 304 304 PHE PHE A . n 
D 2 293 ARG 293 305 305 ARG ARG A . n 
D 2 294 LEU 294 306 306 LEU LEU A . n 
D 2 295 LEU 295 307 307 LEU LEU A . n 
D 2 296 GLN 296 308 308 GLN GLN A . n 
D 2 297 ASN 297 309 309 ASN ASN A . n 
D 2 298 SER 298 310 310 SER SER A . n 
D 2 299 GLN 299 311 311 GLN GLN A . n 
D 2 300 VAL 300 312 312 VAL VAL A . n 
D 2 301 TYR 301 313 313 TYR TYR A . n 
D 2 302 SER 302 314 314 SER SER A . n 
D 2 303 LEU 303 315 315 LEU LEU A . n 
D 2 304 ILE 304 316 316 ILE ILE A . n 
D 2 305 ARG 305 317 317 ARG ARG A . n 
D 2 306 PRO 306 318 318 PRO PRO A . n 
D 2 307 ASN 307 319 319 ASN ASN A . n 
D 2 308 GLU 308 320 320 GLU GLU A . n 
D 2 309 ASN 309 321 321 ASN ASN A . n 
D 2 310 PRO 310 322 322 PRO PRO A . n 
D 2 311 ALA 311 323 323 ALA ALA A . n 
D 2 312 HIS 312 324 324 HIS HIS A . n 
D 2 313 LYS 313 325 325 LYS LYS A . n 
D 2 314 SER 314 326 326 SER SER A . n 
D 2 315 GLN 315 327 327 GLN GLN A . n 
D 2 316 LEU 316 328 328 LEU LEU A . n 
D 2 317 VAL 317 329 329 VAL VAL A . n 
D 2 318 TRP 318 330 330 TRP TRP A . n 
D 2 319 MET 319 331 331 MET MET A . n 
D 2 320 ALA 320 332 332 ALA ALA A . n 
D 2 321 CYS 321 333 333 CYS CYS A . n 
D 2 322 HIS 322 334 334 HIS HIS A . n 
D 2 323 SER 323 335 335 SER SER A . n 
D 2 324 ALA 324 336 336 ALA ALA A . n 
D 2 325 ALA 325 337 337 ALA ALA A . n 
D 2 326 PHE 326 338 338 PHE PHE A . n 
D 2 327 GLU 327 339 339 GLU GLU A . n 
D 2 328 ASP 328 340 340 ASP ASP A . n 
D 2 329 LEU 329 341 341 LEU LEU A . n 
D 2 330 ARG 330 342 342 ARG ARG A . n 
D 2 331 VAL 331 343 343 VAL VAL A . n 
D 2 332 SER 332 344 344 SER SER A . n 
D 2 333 SER 333 345 345 SER SER A . n 
D 2 334 PHE 334 346 346 PHE PHE A . n 
D 2 335 ILE 335 347 347 ILE ILE A . n 
D 2 336 ARG 336 348 348 ARG ARG A . n 
D 2 337 GLY 337 349 349 GLY GLY A . n 
D 2 338 THR 338 350 350 THR THR A . n 
D 2 339 LYS 339 351 351 LYS LYS A . n 
D 2 340 VAL 340 352 352 VAL VAL A . n 
D 2 341 VAL 341 353 353 VAL VAL A . n 
D 2 342 PRO 342 354 354 PRO PRO A . n 
D 2 343 ARG 343 355 355 ARG ARG A . n 
D 2 344 GLY 344 356 356 GLY GLY A . n 
D 2 345 LYS 345 357 357 LYS LYS A . n 
D 2 346 LEU 346 358 358 LEU LEU A . n 
D 2 347 SER 347 359 359 SER SER A . n 
D 2 348 THR 348 360 360 THR THR A . n 
D 2 349 ARG 349 361 361 ARG ARG A . n 
D 2 350 GLY 350 362 362 GLY GLY A . n 
D 2 351 VAL 351 363 363 VAL VAL A . n 
D 2 352 GLN 352 364 364 GLN GLN A . n 
D 2 353 ILE 353 365 365 ILE ILE A . n 
D 2 354 ALA 354 366 366 ALA ALA A . n 
D 2 355 SER 355 367 367 SER SER A . n 
D 2 356 ASN 356 368 368 ASN ASN A . n 
D 2 357 GLU 357 369 369 GLU GLU A . n 
D 2 358 ASN 358 370 370 ASN ASN A . n 
D 2 359 MET 359 371 371 MET MET A . n 
D 2 360 GLU 360 372 372 GLU GLU A . n 
D 2 361 THR 361 373 373 THR THR A . n 
D 2 362 MET 362 374 374 MET MET A . n 
D 2 363 GLU 363 375 375 GLU GLU A . n 
D 2 364 SER 364 376 376 SER SER A . n 
D 2 365 SER 365 377 377 SER SER A . n 
D 2 366 THR 366 378 378 THR THR A . n 
D 2 367 LEU 367 379 379 LEU LEU A . n 
D 2 368 GLU 368 380 380 GLU GLU A . n 
D 2 369 LEU 369 381 381 LEU LEU A . n 
D 2 370 ARG 370 382 382 ARG ARG A . n 
D 2 371 SER 371 383 383 SER SER A . n 
D 2 372 ARG 372 384 384 ARG ARG A . n 
D 2 373 TYR 373 385 385 TYR TYR A . n 
D 2 374 TRP 374 386 386 TRP TRP A . n 
D 2 375 ALA 375 387 387 ALA ALA A . n 
D 2 376 ILE 376 388 388 ILE ILE A . n 
D 2 377 ARG 377 389 389 ARG ARG A . n 
D 2 378 THR 378 390 390 THR THR A . n 
D 2 379 ARG 379 391 391 ARG ARG A . n 
D 2 380 SER 380 392 392 SER SER A . n 
D 2 381 GLY 381 393 393 GLY GLY A . n 
D 2 382 GLY 382 394 394 GLY GLY A . n 
D 2 383 ASN 383 395 395 ASN ASN A . n 
D 2 384 THR 384 396 396 THR THR A . n 
D 2 385 ASN 385 397 397 ASN ASN A . n 
D 2 386 GLN 386 398 ?   ?   ?   A . n 
D 2 387 GLN 387 399 ?   ?   ?   A . n 
D 2 388 ARG 388 400 ?   ?   ?   A . n 
D 2 389 ALA 389 401 ?   ?   ?   A . n 
D 2 390 SER 390 402 ?   ?   ?   A . n 
D 2 391 SER 391 403 ?   ?   ?   A . n 
D 2 392 GLY 392 404 ?   ?   ?   A . n 
D 2 393 GLN 393 405 ?   ?   ?   A . n 
D 2 394 ILE 394 406 ?   ?   ?   A . n 
D 2 395 SER 395 407 ?   ?   ?   A . n 
D 2 396 ILE 396 408 ?   ?   ?   A . n 
D 2 397 GLN 397 409 ?   ?   ?   A . n 
D 2 398 PRO 398 410 ?   ?   ?   A . n 
D 2 399 THR 399 411 ?   ?   ?   A . n 
D 2 400 PHE 400 412 ?   ?   ?   A . n 
D 2 401 SER 401 413 ?   ?   ?   A . n 
D 2 402 VAL 402 414 ?   ?   ?   A . n 
D 2 403 GLN 403 415 ?   ?   ?   A . n 
D 2 404 ARG 404 416 ?   ?   ?   A . n 
D 2 405 ASN 405 417 ?   ?   ?   A . n 
D 2 406 LEU 406 418 ?   ?   ?   A . n 
D 2 407 PRO 407 419 ?   ?   ?   A . n 
D 2 408 PHE 408 420 ?   ?   ?   A . n 
D 2 409 ASP 409 421 ?   ?   ?   A . n 
D 2 410 ARG 410 422 ?   ?   ?   A . n 
D 2 411 PRO 411 423 ?   ?   ?   A . n 
D 2 412 THR 412 424 ?   ?   ?   A . n 
D 2 413 ILE 413 425 ?   ?   ?   A . n 
D 2 414 MET 414 426 ?   ?   ?   A . n 
D 2 415 ALA 415 427 ?   ?   ?   A . n 
D 2 416 ALA 416 428 ?   ?   ?   A . n 
D 2 417 PHE 417 429 ?   ?   ?   A . n 
D 2 418 THR 418 430 ?   ?   ?   A . n 
D 2 419 GLY 419 431 ?   ?   ?   A . n 
D 2 420 ASN 420 432 ?   ?   ?   A . n 
D 2 421 THR 421 433 ?   ?   ?   A . n 
D 2 422 GLU 422 434 ?   ?   ?   A . n 
D 2 423 GLY 423 435 ?   ?   ?   A . n 
D 2 424 ARG 424 436 ?   ?   ?   A . n 
D 2 425 THR 425 437 ?   ?   ?   A . n 
D 2 426 SER 426 438 ?   ?   ?   A . n 
D 2 427 ASP 427 439 439 ASP ASP A . n 
D 2 428 MET 428 440 440 MET MET A . n 
D 2 429 ARG 429 441 441 ARG ARG A . n 
D 2 430 THR 430 442 442 THR THR A . n 
D 2 431 GLU 431 443 443 GLU GLU A . n 
D 2 432 ILE 432 444 444 ILE ILE A . n 
D 2 433 ILE 433 445 445 ILE ILE A . n 
D 2 434 ARG 434 446 446 ARG ARG A . n 
D 2 435 LEU 435 447 447 LEU LEU A . n 
D 2 436 MET 436 448 448 MET MET A . n 
D 2 437 GLU 437 449 449 GLU GLU A . n 
D 2 438 SER 438 450 450 SER SER A . n 
D 2 439 ALA 439 451 451 ALA ALA A . n 
D 2 440 ARG 440 452 452 ARG ARG A . n 
D 2 441 PRO 441 453 453 PRO PRO A . n 
D 2 442 GLU 442 454 454 GLU GLU A . n 
D 2 443 ASP 443 455 455 ASP ASP A . n 
D 2 444 VAL 444 456 456 VAL VAL A . n 
D 2 445 SER 445 457 457 SER SER A . n 
D 2 446 PHE 446 458 458 PHE PHE A . n 
D 2 447 GLN 447 459 459 GLN GLN A . n 
D 2 448 GLY 448 460 460 GLY GLY A . n 
D 2 449 ARG 449 461 461 ARG ARG A . n 
D 2 450 GLY 450 462 462 GLY GLY A . n 
D 2 451 VAL 451 463 463 VAL VAL A . n 
D 2 452 PHE 452 464 464 PHE PHE A . n 
D 2 453 GLU 453 465 465 GLU GLU A . n 
D 2 454 LEU 454 466 466 LEU LEU A . n 
D 2 455 SER 455 467 467 SER SER A . n 
D 2 456 ASP 456 468 468 ASP ASP A . n 
D 2 457 GLU 457 469 469 GLU GLU A . n 
D 2 458 LYS 458 470 470 LYS LYS A . n 
D 2 459 ALA 459 471 471 ALA ALA A . n 
D 2 460 THR 460 472 472 THR THR A . n 
D 2 461 SER 461 473 473 SER SER A . n 
D 2 462 PRO 462 474 474 PRO PRO A . n 
D 2 463 ILE 463 475 475 ILE ILE A . n 
D 2 464 VAL 464 476 476 VAL VAL A . n 
D 2 465 PRO 465 477 477 PRO PRO A . n 
D 2 466 SER 466 478 478 SER SER A . n 
D 2 467 PHE 467 479 479 PHE PHE A . n 
D 2 468 ASP 468 480 ?   ?   ?   A . n 
D 2 469 MET 469 481 ?   ?   ?   A . n 
D 2 470 SER 470 482 ?   ?   ?   A . n 
D 2 471 ASN 471 483 ?   ?   ?   A . n 
D 2 472 GLU 472 484 484 GLU GLU A . n 
D 2 473 GLY 473 485 485 GLY GLY A . n 
D 2 474 SER 474 486 486 SER SER A . n 
D 2 475 TYR 475 487 487 TYR TYR A . n 
D 2 476 PHE 476 488 488 PHE PHE A . n 
D 2 477 PHE 477 489 489 PHE PHE A . n 
D 2 478 GLY 478 490 490 GLY GLY A . n 
D 2 479 ASP 479 491 ?   ?   ?   A . n 
D 2 480 ASN 480 492 ?   ?   ?   A . n 
D 2 481 ALA 481 493 ?   ?   ?   A . n 
D 2 482 GLU 482 494 ?   ?   ?   A . n 
D 2 483 GLU 483 495 ?   ?   ?   A . n 
D 2 484 TYR 484 496 ?   ?   ?   A . n 
D 2 485 ASP 485 497 ?   ?   ?   A . n 
D 2 486 ASN 486 498 ?   ?   ?   A . n 
D 2 487 LEU 487 499 ?   ?   ?   A . n 
D 2 488 GLU 488 500 ?   ?   ?   A . n 
D 2 489 HIS 489 501 ?   ?   ?   A . n 
D 2 490 HIS 490 502 ?   ?   ?   A . n 
D 2 491 HIS 491 503 ?   ?   ?   A . n 
D 2 492 HIS 492 504 ?   ?   ?   A . n 
D 2 493 HIS 493 505 ?   ?   ?   A . n 
D 2 494 HIS 494 506 ?   ?   ?   A . n 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9GAQ 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9GAQ 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9GAQ 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_struct.entry_id                     9GAQ 
_struct.title                        
'CryoEM structure of influenza A RNP-like particle double-stranded assembled with a 14-mer RNA.' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9GAQ 
_struct_keywords.text            'Nucleoprotein, RNA, complex, RNP-like, influenza virus, VIRAL PROTEIN' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 2 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 PDB 9GAQ         9GAQ   ? 1 ? 1  
2 UNP Q1K9H2_I33A0 Q1K9H2 ? 2 
;TDGERQNATEIRASVGKMIDGIGRFYIQMCTELKLSDYEGRLIQNSLTIERMVLSAFDERRNKYLEEHPSAGKDPKKTGG
PIYRRVDGKWRRELILYDKEEIRRIWRQANNGDDATAGLTHMMIWHSNLNDATYQRTRALVRTGMDPRMCSLMQGSTLPR
RSGAAGAAVKGVGTMVMELIRMIKRGINDRNFWRGENGRRTRIAYERMCNILKGKFQTAAQRTMVDQVRESRNPGNAEFE
DLIFLARSALILRGSVAHKSCLPACVYGSAVASGYDFEREGYSLVGIDPFRLLQNSQVYSLIRPNENPAHKSQLVWMACH
SAAFEDLRVSSFIRGTKVVPRGKLSTRGVQIASNENMETMESSTLELRSRYWAIRTRSGGNTNQQRASSGQISIQPTFSV
QRNLPFDRPTIMAAFTGNTEGRTSDMRTEIIRLMESARPEDVSFQGRGVFELSDEKATSPIVPSFDMSNEGSYFFGDNAE
EYDN
;
15 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9GAQ C 1 ? 14  ? 9GAQ   7  ? 20  ? 7  20  
2 1 9GAQ D 1 ? 14  ? 9GAQ   1  ? 14  ? 1  14  
3 2 9GAQ B 3 ? 486 ? Q1K9H2 15 ? 498 ? 15 498 
4 2 9GAQ A 3 ? 486 ? Q1K9H2 15 ? 498 ? 15 498 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
3 9GAQ HIS B 1   ? UNP Q1K9H2 ? ? 'expression tag' 13  1  
3 9GAQ MET B 2   ? UNP Q1K9H2 ? ? 'expression tag' 14  2  
3 9GAQ LEU B 487 ? UNP Q1K9H2 ? ? 'expression tag' 499 3  
3 9GAQ GLU B 488 ? UNP Q1K9H2 ? ? 'expression tag' 500 4  
3 9GAQ HIS B 489 ? UNP Q1K9H2 ? ? 'expression tag' 501 5  
3 9GAQ HIS B 490 ? UNP Q1K9H2 ? ? 'expression tag' 502 6  
3 9GAQ HIS B 491 ? UNP Q1K9H2 ? ? 'expression tag' 503 7  
3 9GAQ HIS B 492 ? UNP Q1K9H2 ? ? 'expression tag' 504 8  
3 9GAQ HIS B 493 ? UNP Q1K9H2 ? ? 'expression tag' 505 9  
3 9GAQ HIS B 494 ? UNP Q1K9H2 ? ? 'expression tag' 506 10 
4 9GAQ HIS A 1   ? UNP Q1K9H2 ? ? 'expression tag' 13  11 
4 9GAQ MET A 2   ? UNP Q1K9H2 ? ? 'expression tag' 14  12 
4 9GAQ LEU A 487 ? UNP Q1K9H2 ? ? 'expression tag' 499 13 
4 9GAQ GLU A 488 ? UNP Q1K9H2 ? ? 'expression tag' 500 14 
4 9GAQ HIS A 489 ? UNP Q1K9H2 ? ? 'expression tag' 501 15 
4 9GAQ HIS A 490 ? UNP Q1K9H2 ? ? 'expression tag' 502 16 
4 9GAQ HIS A 491 ? UNP Q1K9H2 ? ? 'expression tag' 503 17 
4 9GAQ HIS A 492 ? UNP Q1K9H2 ? ? 'expression tag' 504 18 
4 9GAQ HIS A 493 ? UNP Q1K9H2 ? ? 'expression tag' 505 19 
4 9GAQ HIS A 494 ? UNP Q1K9H2 ? ? 'expression tag' 506 20 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   tetrameric 
_pdbx_struct_assembly.oligomeric_count     4 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1  A,B,C,D 
1 2  A,B,C,D 
1 3  A,B,C,D 
1 4  A,B,C,D 
1 5  A,B,C,D 
1 6  A,B,C,D 
1 7  A,B,C,D 
1 8  A,B,C,D 
1 9  A,B,C,D 
1 10 A,B,C,D 
1 11 A,B,C,D 
1 12 A,B,C,D 
1 13 A,B,C,D 
1 14 A,B,C,D 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1  'identity operation'       1_555 x,y,z 1.000000  0.000000  0.000000  0.00000   -0.000000 1.000000  0.000000  0.00000   0.000000 
-0.000000 1.000000 0.00000   
2  'point symmetry operation' ?     ?     -0.989801 0.142456  0.000000  421.28334 -0.142456 -0.989801 0.000000  477.33722 0.000000 
-0.000000 1.000000 -73.65027 
3  'point symmetry operation' ?     ?     -0.415328 0.909672  0.000000  118.91918 -0.909672 -0.415328 0.000000  523.60888 0.000001 
-0.000000 1.000000 -49.10033 
4  'point symmetry operation' ?     ?     0.540681  0.841228  -0.000000 -83.48863 -0.841228 0.540681  0.000000  294.27018 0.000000 
0.000000  1.000000 -24.55018 
5  'point symmetry operation' ?     ?     0.540681  -0.841228 0.000000  292.68880 0.841228  0.540681  0.000000  -88.87354 
-0.000000 -0.000000 1.000000 24.55007  
6  'point symmetry operation' ?     ?     -0.415328 -0.909672 0.000000  525.70234 0.909672  -0.415328 0.000000  109.29251 
-0.000000 0.000000  1.000000 49.09958  
7  'point symmetry operation' ?     ?     -0.989801 -0.142456 0.000000  484.98637 0.142456  -0.989801 0.000000  412.45452 0.000000 
0.000000  1.000000 73.64994  
8  'point symmetry operation' ?     ?     0.989801  -0.142456 -0.000000 34.17412  0.142456  0.989801  0.000000  -30.16093 0.000000 
-0.000000 1.000000 -73.64983 
9  'point symmetry operation' ?     ?     0.415328  -0.909672 -0.000000 336.53828 0.909672  0.415328  -0.000000 -76.43259 0.000000 
-0.000000 1.000000 -49.09977 
10 'point symmetry operation' ?     ?     -0.540681 -0.841228 0.000000  538.94609 0.841228  -0.540681 0.000000  152.90611 0.000000 
0.000000  1.000000 -24.54992 
11 'point symmetry operation' ?     ?     -1.000000 0.000000  -0.000000 455.45746 -0.000000 -1.000000 0.000000  447.17629 
-0.000000 0.000000  1.000000 -0.00010  
12 'point symmetry operation' ?     ?     -0.540681 0.841228  -0.000000 162.76867 -0.841228 -0.540681 -0.000000 536.04982 
-0.000000 0.000000  1.000000 24.54983  
13 'point symmetry operation' ?     ?     0.415328  0.909672  -0.000000 -70.24487 -0.909672 0.415328  -0.000000 337.88378 
-0.000000 0.000000  1.000000 49.10032  
14 'point symmetry operation' ?     ?     0.989801  0.142456  -0.000000 -29.52891 -0.142456 0.989801  -0.000000 34.72178  0.000000 
0.000000  1.000000 73.64995  
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASP C 409 ? MET C 414 ? ASP B 421 MET B 426 1 ? 6  
HELX_P HELX_P2  AA2 GLY D 5   ? LYS D 36  ? GLY A 17  LYS A 48  1 ? 32 
HELX_P HELX_P3  AA3 SER D 38  ? ARG D 43  ? SER A 50  ARG A 55  1 ? 6  
HELX_P HELX_P4  AA4 LEU D 44  ? PHE D 59  ? LEU A 56  PHE A 71  1 ? 16 
HELX_P HELX_P5  AA5 ASP D 60  ? HIS D 70  ? ASP A 72  HIS A 82  1 ? 11 
HELX_P HELX_P6  AA6 LYS D 101 ? ASN D 112 ? LYS A 113 ASN A 124 1 ? 12 
HELX_P HELX_P7  AA7 ALA D 117 ? TYR D 136 ? ALA A 129 TYR A 148 1 ? 20 
HELX_P HELX_P8  AA8 ARG D 138 ? GLY D 146 ? ARG A 150 GLY A 158 1 ? 9  
HELX_P HELX_P9  AA9 CYS D 152 ? GLN D 156 ? CYS A 164 GLN A 168 5 ? 5  
HELX_P HELX_P10 AB1 GLY D 165 ? LYS D 172 ? GLY A 177 LYS A 184 1 ? 8  
HELX_P HELX_P11 AB2 GLY D 173 ? ASP D 191 ? GLY A 185 ASP A 203 1 ? 19 
HELX_P HELX_P12 AB3 GLY D 197 ? PHE D 218 ? GLY A 209 PHE A 230 1 ? 22 
HELX_P HELX_P13 AB4 THR D 220 ? SER D 233 ? THR A 232 SER A 245 1 ? 14 
HELX_P HELX_P14 AB5 GLY D 237 ? ALA D 251 ? GLY A 249 ALA A 263 1 ? 15 
HELX_P HELX_P15 AB6 PRO D 265 ? SER D 275 ? PRO A 277 SER A 287 1 ? 11 
HELX_P HELX_P16 AB7 ASP D 278 ? GLY D 283 ? ASP A 290 GLY A 295 1 ? 6  
HELX_P HELX_P17 AB8 ILE D 289 ? ASN D 297 ? ILE A 301 ASN A 309 1 ? 9  
HELX_P HELX_P18 AB9 ASN D 309 ? SER D 323 ? ASN A 321 SER A 335 1 ? 15 
HELX_P HELX_P19 AC1 ASP D 328 ? GLY D 337 ? ASP A 340 GLY A 349 1 ? 10 
HELX_P HELX_P20 AC2 PRO D 342 ? LEU D 346 ? PRO A 354 LEU A 358 5 ? 5  
HELX_P HELX_P21 AC3 MET D 428 ? ALA D 439 ? MET A 440 ALA A 451 1 ? 12 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 2 ? 
AA2 ? 2 ? 
AA3 ? 2 ? 
AA4 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ARG C 404 ? ASN C 405 ? ARG B 416 ASN B 417 
AA1 2 VAL D 444 ? SER D 445 ? VAL A 456 SER A 457 
AA2 1 LYS D 79  ? VAL D 88  ? LYS A 91  VAL A 100 
AA2 2 LYS D 91  ? ASP D 100 ? LYS A 103 ASP A 112 
AA3 1 TYR D 301 ? ILE D 304 ? TYR A 313 ILE A 316 
AA3 2 GLU D 363 ? THR D 366 ? GLU A 375 THR A 378 
AA4 1 TYR D 373 ? TRP D 374 ? TYR A 385 TRP A 386 
AA4 2 PHE D 452 ? GLU D 453 ? PHE A 464 GLU A 465 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ARG C 404 ? N ARG B 416 O SER D 445 ? O SER A 457 
AA2 1 2 N THR D 80  ? N THR A 92  O TYR D 99  ? O TYR A 111 
AA3 1 2 N ILE D 304 ? N ILE A 316 O GLU D 363 ? O GLU A 375 
AA4 1 2 N TRP D 374 ? N TRP A 386 O PHE D 452 ? O PHE A 464 
# 
_pdbx_entry_details.entry_id                   9GAQ 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_rmsd_bond.id                        1 
_pdbx_validate_rmsd_bond.PDB_model_num             1 
_pdbx_validate_rmsd_bond.auth_atom_id_1            P 
_pdbx_validate_rmsd_bond.auth_asym_id_1            D 
_pdbx_validate_rmsd_bond.auth_comp_id_1            U 
_pdbx_validate_rmsd_bond.auth_seq_id_1             1 
_pdbx_validate_rmsd_bond.PDB_ins_code_1            ? 
_pdbx_validate_rmsd_bond.label_alt_id_1            ? 
_pdbx_validate_rmsd_bond.auth_atom_id_2            OP3 
_pdbx_validate_rmsd_bond.auth_asym_id_2            D 
_pdbx_validate_rmsd_bond.auth_comp_id_2            U 
_pdbx_validate_rmsd_bond.auth_seq_id_2             1 
_pdbx_validate_rmsd_bond.PDB_ins_code_2            ? 
_pdbx_validate_rmsd_bond.label_alt_id_2            ? 
_pdbx_validate_rmsd_bond.bond_value                1.517 
_pdbx_validate_rmsd_bond.bond_target_value         1.607 
_pdbx_validate_rmsd_bond.bond_deviation            -0.090 
_pdbx_validate_rmsd_bond.bond_standard_deviation   0.012 
_pdbx_validate_rmsd_bond.linker_flag               N 
# 
loop_
_pdbx_validate_rmsd_angle.id 
_pdbx_validate_rmsd_angle.PDB_model_num 
_pdbx_validate_rmsd_angle.auth_atom_id_1 
_pdbx_validate_rmsd_angle.auth_asym_id_1 
_pdbx_validate_rmsd_angle.auth_comp_id_1 
_pdbx_validate_rmsd_angle.auth_seq_id_1 
_pdbx_validate_rmsd_angle.PDB_ins_code_1 
_pdbx_validate_rmsd_angle.label_alt_id_1 
_pdbx_validate_rmsd_angle.auth_atom_id_2 
_pdbx_validate_rmsd_angle.auth_asym_id_2 
_pdbx_validate_rmsd_angle.auth_comp_id_2 
_pdbx_validate_rmsd_angle.auth_seq_id_2 
_pdbx_validate_rmsd_angle.PDB_ins_code_2 
_pdbx_validate_rmsd_angle.label_alt_id_2 
_pdbx_validate_rmsd_angle.auth_atom_id_3 
_pdbx_validate_rmsd_angle.auth_asym_id_3 
_pdbx_validate_rmsd_angle.auth_comp_id_3 
_pdbx_validate_rmsd_angle.auth_seq_id_3 
_pdbx_validate_rmsd_angle.PDB_ins_code_3 
_pdbx_validate_rmsd_angle.label_alt_id_3 
_pdbx_validate_rmsd_angle.angle_value 
_pdbx_validate_rmsd_angle.angle_target_value 
_pdbx_validate_rmsd_angle.angle_deviation 
_pdbx_validate_rmsd_angle.angle_standard_deviation 
_pdbx_validate_rmsd_angle.linker_flag 
1 1 "C3'" C C 8  ? ? "O3'" C C 8  ? ? P C U 9  ? ? 109.50 119.70 -10.20 1.20 Y 
2 1 "C3'" C C 12 ? ? "O3'" C C 12 ? ? P C U 13 ? ? 108.52 119.70 -11.18 1.20 Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 SER B 407 ? ? -98.83  -83.20 
2  1 ILE B 408 ? ? 176.24  158.35 
3  1 PRO B 410 ? ? -53.07  109.05 
4  1 LEU B 418 ? ? -59.56  109.08 
5  1 TRP A 207 ? ? 52.33   -2.63  
6  1 ASN A 319 ? ? 31.66   57.37  
7  1 SER A 359 ? ? -91.18  57.14  
8  1 MET A 371 ? ? -93.93  48.50  
9  1 LEU A 381 ? ? -92.09  53.15  
10 1 PRO A 453 ? ? -68.11  40.96  
11 1 GLU A 454 ? ? -140.25 -2.55  
12 1 PHE A 489 ? ? -93.59  53.86  
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9GAQ 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    9GAQ 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.6 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               242730 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               HELICAL 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       
;20 mM HEPES
150 mM NaCl
5 mM beta-mercaptoethanol
2 mM methyl-PEG8-NHS
;
_em_buffer.pH            7.5 
# 
loop_
_em_entity_assembly.id 
_em_entity_assembly.parent_id 
_em_entity_assembly.source 
_em_entity_assembly.type 
_em_entity_assembly.name 
_em_entity_assembly.details 
_em_entity_assembly.synonym 
_em_entity_assembly.oligomeric_details 
_em_entity_assembly.entity_id_list 
1 0 'MULTIPLE SOURCES' COMPLEX 'complex NP-RNA' ? ? ? '1, 2' 
2 1 RECOMBINANT        COMPLEX RNA              ? ? ? 1      
3 1 RECOMBINANT        COMPLEX Nucleoprotein    ? ? ? 2      
# 
_em_imaging.entry_id                        9GAQ 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'TFS GLACIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            200 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      2.7 
_em_imaging.nominal_defocus_min             500 
_em_imaging.nominal_defocus_max             2000 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           36000 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         NITROGEN 
# 
_em_vitrification.entry_id              9GAQ 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              98 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   298 
_em_vitrification.instrument            'FEI VITROBOT MARK IV' 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               '5 seconds blot at force 0' 
# 
_em_experiment.entry_id                9GAQ 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   HELICAL 
_em_experiment.aggregation_state       FILAMENT 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 C U   7   ? A U   1   
2   1 Y 1 C C   14  ? A C   8   
3   1 Y 1 C U   15  ? A U   9   
4   1 Y 1 C C   16  ? A C   10  
5   1 Y 1 C U   17  ? A U   11  
6   1 Y 1 C C   18  ? A C   12  
7   1 Y 1 C U   19  ? A U   13  
8   1 Y 1 C C   20  ? A C   14  
9   1 Y 1 D C   8   ? B C   8   
10  1 Y 1 D U   9   ? B U   9   
11  1 Y 1 D C   10  ? B C   10  
12  1 Y 1 D U   11  ? B U   11  
13  1 Y 1 D C   12  ? B C   12  
14  1 Y 1 D U   13  ? B U   13  
15  1 Y 1 D C   14  ? B C   14  
16  1 Y 1 B HIS 13  ? C HIS 1   
17  1 Y 1 B MET 14  ? C MET 2   
18  1 Y 1 B THR 15  ? C THR 3   
19  1 Y 1 B ASP 16  ? C ASP 4   
20  1 Y 1 B GLY 17  ? C GLY 5   
21  1 Y 1 B GLU 18  ? C GLU 6   
22  1 Y 1 B ARG 19  ? C ARG 7   
23  1 Y 1 B GLN 20  ? C GLN 8   
24  1 Y 1 B ASN 21  ? C ASN 9   
25  1 Y 1 B ALA 22  ? C ALA 10  
26  1 Y 1 B THR 23  ? C THR 11  
27  1 Y 1 B GLU 24  ? C GLU 12  
28  1 Y 1 B ILE 25  ? C ILE 13  
29  1 Y 1 B ARG 26  ? C ARG 14  
30  1 Y 1 B ALA 27  ? C ALA 15  
31  1 Y 1 B SER 28  ? C SER 16  
32  1 Y 1 B VAL 29  ? C VAL 17  
33  1 Y 1 B GLY 30  ? C GLY 18  
34  1 Y 1 B LYS 31  ? C LYS 19  
35  1 Y 1 B MET 32  ? C MET 20  
36  1 Y 1 B ILE 33  ? C ILE 21  
37  1 Y 1 B ASP 34  ? C ASP 22  
38  1 Y 1 B GLY 35  ? C GLY 23  
39  1 Y 1 B ILE 36  ? C ILE 24  
40  1 Y 1 B GLY 37  ? C GLY 25  
41  1 Y 1 B ARG 38  ? C ARG 26  
42  1 Y 1 B PHE 39  ? C PHE 27  
43  1 Y 1 B TYR 40  ? C TYR 28  
44  1 Y 1 B ILE 41  ? C ILE 29  
45  1 Y 1 B GLN 42  ? C GLN 30  
46  1 Y 1 B MET 43  ? C MET 31  
47  1 Y 1 B CYS 44  ? C CYS 32  
48  1 Y 1 B THR 45  ? C THR 33  
49  1 Y 1 B GLU 46  ? C GLU 34  
50  1 Y 1 B LEU 47  ? C LEU 35  
51  1 Y 1 B LYS 48  ? C LYS 36  
52  1 Y 1 B LEU 49  ? C LEU 37  
53  1 Y 1 B SER 50  ? C SER 38  
54  1 Y 1 B ASP 51  ? C ASP 39  
55  1 Y 1 B TYR 52  ? C TYR 40  
56  1 Y 1 B GLU 53  ? C GLU 41  
57  1 Y 1 B GLY 54  ? C GLY 42  
58  1 Y 1 B ARG 55  ? C ARG 43  
59  1 Y 1 B LEU 56  ? C LEU 44  
60  1 Y 1 B ILE 57  ? C ILE 45  
61  1 Y 1 B GLN 58  ? C GLN 46  
62  1 Y 1 B ASN 59  ? C ASN 47  
63  1 Y 1 B SER 60  ? C SER 48  
64  1 Y 1 B LEU 61  ? C LEU 49  
65  1 Y 1 B THR 62  ? C THR 50  
66  1 Y 1 B ILE 63  ? C ILE 51  
67  1 Y 1 B GLU 64  ? C GLU 52  
68  1 Y 1 B ARG 65  ? C ARG 53  
69  1 Y 1 B MET 66  ? C MET 54  
70  1 Y 1 B VAL 67  ? C VAL 55  
71  1 Y 1 B LEU 68  ? C LEU 56  
72  1 Y 1 B SER 69  ? C SER 57  
73  1 Y 1 B ALA 70  ? C ALA 58  
74  1 Y 1 B PHE 71  ? C PHE 59  
75  1 Y 1 B ASP 72  ? C ASP 60  
76  1 Y 1 B GLU 73  ? C GLU 61  
77  1 Y 1 B ARG 74  ? C ARG 62  
78  1 Y 1 B ARG 75  ? C ARG 63  
79  1 Y 1 B ASN 76  ? C ASN 64  
80  1 Y 1 B LYS 77  ? C LYS 65  
81  1 Y 1 B TYR 78  ? C TYR 66  
82  1 Y 1 B LEU 79  ? C LEU 67  
83  1 Y 1 B GLU 80  ? C GLU 68  
84  1 Y 1 B GLU 81  ? C GLU 69  
85  1 Y 1 B HIS 82  ? C HIS 70  
86  1 Y 1 B PRO 83  ? C PRO 71  
87  1 Y 1 B SER 84  ? C SER 72  
88  1 Y 1 B ALA 85  ? C ALA 73  
89  1 Y 1 B GLY 86  ? C GLY 74  
90  1 Y 1 B LYS 87  ? C LYS 75  
91  1 Y 1 B ASP 88  ? C ASP 76  
92  1 Y 1 B PRO 89  ? C PRO 77  
93  1 Y 1 B LYS 90  ? C LYS 78  
94  1 Y 1 B LYS 91  ? C LYS 79  
95  1 Y 1 B THR 92  ? C THR 80  
96  1 Y 1 B GLY 93  ? C GLY 81  
97  1 Y 1 B GLY 94  ? C GLY 82  
98  1 Y 1 B PRO 95  ? C PRO 83  
99  1 Y 1 B ILE 96  ? C ILE 84  
100 1 Y 1 B TYR 97  ? C TYR 85  
101 1 Y 1 B ARG 98  ? C ARG 86  
102 1 Y 1 B ARG 99  ? C ARG 87  
103 1 Y 1 B VAL 100 ? C VAL 88  
104 1 Y 1 B ASP 101 ? C ASP 89  
105 1 Y 1 B GLY 102 ? C GLY 90  
106 1 Y 1 B LYS 103 ? C LYS 91  
107 1 Y 1 B TRP 104 ? C TRP 92  
108 1 Y 1 B ARG 105 ? C ARG 93  
109 1 Y 1 B ARG 106 ? C ARG 94  
110 1 Y 1 B GLU 107 ? C GLU 95  
111 1 Y 1 B LEU 108 ? C LEU 96  
112 1 Y 1 B ILE 109 ? C ILE 97  
113 1 Y 1 B LEU 110 ? C LEU 98  
114 1 Y 1 B TYR 111 ? C TYR 99  
115 1 Y 1 B ASP 112 ? C ASP 100 
116 1 Y 1 B LYS 113 ? C LYS 101 
117 1 Y 1 B GLU 114 ? C GLU 102 
118 1 Y 1 B GLU 115 ? C GLU 103 
119 1 Y 1 B ILE 116 ? C ILE 104 
120 1 Y 1 B ARG 117 ? C ARG 105 
121 1 Y 1 B ARG 118 ? C ARG 106 
122 1 Y 1 B ILE 119 ? C ILE 107 
123 1 Y 1 B TRP 120 ? C TRP 108 
124 1 Y 1 B ARG 121 ? C ARG 109 
125 1 Y 1 B GLN 122 ? C GLN 110 
126 1 Y 1 B ALA 123 ? C ALA 111 
127 1 Y 1 B ASN 124 ? C ASN 112 
128 1 Y 1 B ASN 125 ? C ASN 113 
129 1 Y 1 B GLY 126 ? C GLY 114 
130 1 Y 1 B ASP 127 ? C ASP 115 
131 1 Y 1 B ASP 128 ? C ASP 116 
132 1 Y 1 B ALA 129 ? C ALA 117 
133 1 Y 1 B THR 130 ? C THR 118 
134 1 Y 1 B ALA 131 ? C ALA 119 
135 1 Y 1 B GLY 132 ? C GLY 120 
136 1 Y 1 B LEU 133 ? C LEU 121 
137 1 Y 1 B THR 134 ? C THR 122 
138 1 Y 1 B HIS 135 ? C HIS 123 
139 1 Y 1 B MET 136 ? C MET 124 
140 1 Y 1 B MET 137 ? C MET 125 
141 1 Y 1 B ILE 138 ? C ILE 126 
142 1 Y 1 B TRP 139 ? C TRP 127 
143 1 Y 1 B HIS 140 ? C HIS 128 
144 1 Y 1 B SER 141 ? C SER 129 
145 1 Y 1 B ASN 142 ? C ASN 130 
146 1 Y 1 B LEU 143 ? C LEU 131 
147 1 Y 1 B ASN 144 ? C ASN 132 
148 1 Y 1 B ASP 145 ? C ASP 133 
149 1 Y 1 B ALA 146 ? C ALA 134 
150 1 Y 1 B THR 147 ? C THR 135 
151 1 Y 1 B TYR 148 ? C TYR 136 
152 1 Y 1 B GLN 149 ? C GLN 137 
153 1 Y 1 B ARG 150 ? C ARG 138 
154 1 Y 1 B THR 151 ? C THR 139 
155 1 Y 1 B ARG 152 ? C ARG 140 
156 1 Y 1 B ALA 153 ? C ALA 141 
157 1 Y 1 B LEU 154 ? C LEU 142 
158 1 Y 1 B VAL 155 ? C VAL 143 
159 1 Y 1 B ARG 156 ? C ARG 144 
160 1 Y 1 B THR 157 ? C THR 145 
161 1 Y 1 B GLY 158 ? C GLY 146 
162 1 Y 1 B MET 159 ? C MET 147 
163 1 Y 1 B ASP 160 ? C ASP 148 
164 1 Y 1 B PRO 161 ? C PRO 149 
165 1 Y 1 B ARG 162 ? C ARG 150 
166 1 Y 1 B MET 163 ? C MET 151 
167 1 Y 1 B CYS 164 ? C CYS 152 
168 1 Y 1 B SER 165 ? C SER 153 
169 1 Y 1 B LEU 166 ? C LEU 154 
170 1 Y 1 B MET 167 ? C MET 155 
171 1 Y 1 B GLN 168 ? C GLN 156 
172 1 Y 1 B GLY 169 ? C GLY 157 
173 1 Y 1 B SER 170 ? C SER 158 
174 1 Y 1 B THR 171 ? C THR 159 
175 1 Y 1 B LEU 172 ? C LEU 160 
176 1 Y 1 B PRO 173 ? C PRO 161 
177 1 Y 1 B ARG 174 ? C ARG 162 
178 1 Y 1 B ARG 175 ? C ARG 163 
179 1 Y 1 B SER 176 ? C SER 164 
180 1 Y 1 B GLY 177 ? C GLY 165 
181 1 Y 1 B ALA 178 ? C ALA 166 
182 1 Y 1 B ALA 179 ? C ALA 167 
183 1 Y 1 B GLY 180 ? C GLY 168 
184 1 Y 1 B ALA 181 ? C ALA 169 
185 1 Y 1 B ALA 182 ? C ALA 170 
186 1 Y 1 B VAL 183 ? C VAL 171 
187 1 Y 1 B LYS 184 ? C LYS 172 
188 1 Y 1 B GLY 185 ? C GLY 173 
189 1 Y 1 B VAL 186 ? C VAL 174 
190 1 Y 1 B GLY 187 ? C GLY 175 
191 1 Y 1 B THR 188 ? C THR 176 
192 1 Y 1 B MET 189 ? C MET 177 
193 1 Y 1 B VAL 190 ? C VAL 178 
194 1 Y 1 B MET 191 ? C MET 179 
195 1 Y 1 B GLU 192 ? C GLU 180 
196 1 Y 1 B LEU 193 ? C LEU 181 
197 1 Y 1 B ILE 194 ? C ILE 182 
198 1 Y 1 B ARG 195 ? C ARG 183 
199 1 Y 1 B MET 196 ? C MET 184 
200 1 Y 1 B ILE 197 ? C ILE 185 
201 1 Y 1 B LYS 198 ? C LYS 186 
202 1 Y 1 B ARG 199 ? C ARG 187 
203 1 Y 1 B GLY 200 ? C GLY 188 
204 1 Y 1 B ILE 201 ? C ILE 189 
205 1 Y 1 B ASN 202 ? C ASN 190 
206 1 Y 1 B ASP 203 ? C ASP 191 
207 1 Y 1 B ARG 204 ? C ARG 192 
208 1 Y 1 B ASN 205 ? C ASN 193 
209 1 Y 1 B PHE 206 ? C PHE 194 
210 1 Y 1 B TRP 207 ? C TRP 195 
211 1 Y 1 B ARG 208 ? C ARG 196 
212 1 Y 1 B GLY 209 ? C GLY 197 
213 1 Y 1 B GLU 210 ? C GLU 198 
214 1 Y 1 B ASN 211 ? C ASN 199 
215 1 Y 1 B GLY 212 ? C GLY 200 
216 1 Y 1 B ARG 213 ? C ARG 201 
217 1 Y 1 B ARG 214 ? C ARG 202 
218 1 Y 1 B THR 215 ? C THR 203 
219 1 Y 1 B ARG 216 ? C ARG 204 
220 1 Y 1 B ILE 217 ? C ILE 205 
221 1 Y 1 B ALA 218 ? C ALA 206 
222 1 Y 1 B TYR 219 ? C TYR 207 
223 1 Y 1 B GLU 220 ? C GLU 208 
224 1 Y 1 B ARG 221 ? C ARG 209 
225 1 Y 1 B MET 222 ? C MET 210 
226 1 Y 1 B CYS 223 ? C CYS 211 
227 1 Y 1 B ASN 224 ? C ASN 212 
228 1 Y 1 B ILE 225 ? C ILE 213 
229 1 Y 1 B LEU 226 ? C LEU 214 
230 1 Y 1 B LYS 227 ? C LYS 215 
231 1 Y 1 B GLY 228 ? C GLY 216 
232 1 Y 1 B LYS 229 ? C LYS 217 
233 1 Y 1 B PHE 230 ? C PHE 218 
234 1 Y 1 B GLN 231 ? C GLN 219 
235 1 Y 1 B THR 232 ? C THR 220 
236 1 Y 1 B ALA 233 ? C ALA 221 
237 1 Y 1 B ALA 234 ? C ALA 222 
238 1 Y 1 B GLN 235 ? C GLN 223 
239 1 Y 1 B ARG 236 ? C ARG 224 
240 1 Y 1 B THR 237 ? C THR 225 
241 1 Y 1 B MET 238 ? C MET 226 
242 1 Y 1 B VAL 239 ? C VAL 227 
243 1 Y 1 B ASP 240 ? C ASP 228 
244 1 Y 1 B GLN 241 ? C GLN 229 
245 1 Y 1 B VAL 242 ? C VAL 230 
246 1 Y 1 B ARG 243 ? C ARG 231 
247 1 Y 1 B GLU 244 ? C GLU 232 
248 1 Y 1 B SER 245 ? C SER 233 
249 1 Y 1 B ARG 246 ? C ARG 234 
250 1 Y 1 B ASN 247 ? C ASN 235 
251 1 Y 1 B PRO 248 ? C PRO 236 
252 1 Y 1 B GLY 249 ? C GLY 237 
253 1 Y 1 B ASN 250 ? C ASN 238 
254 1 Y 1 B ALA 251 ? C ALA 239 
255 1 Y 1 B GLU 252 ? C GLU 240 
256 1 Y 1 B PHE 253 ? C PHE 241 
257 1 Y 1 B GLU 254 ? C GLU 242 
258 1 Y 1 B ASP 255 ? C ASP 243 
259 1 Y 1 B LEU 256 ? C LEU 244 
260 1 Y 1 B ILE 257 ? C ILE 245 
261 1 Y 1 B PHE 258 ? C PHE 246 
262 1 Y 1 B LEU 259 ? C LEU 247 
263 1 Y 1 B ALA 260 ? C ALA 248 
264 1 Y 1 B ARG 261 ? C ARG 249 
265 1 Y 1 B SER 262 ? C SER 250 
266 1 Y 1 B ALA 263 ? C ALA 251 
267 1 Y 1 B LEU 264 ? C LEU 252 
268 1 Y 1 B ILE 265 ? C ILE 253 
269 1 Y 1 B LEU 266 ? C LEU 254 
270 1 Y 1 B ARG 267 ? C ARG 255 
271 1 Y 1 B GLY 268 ? C GLY 256 
272 1 Y 1 B SER 269 ? C SER 257 
273 1 Y 1 B VAL 270 ? C VAL 258 
274 1 Y 1 B ALA 271 ? C ALA 259 
275 1 Y 1 B HIS 272 ? C HIS 260 
276 1 Y 1 B LYS 273 ? C LYS 261 
277 1 Y 1 B SER 274 ? C SER 262 
278 1 Y 1 B CYS 275 ? C CYS 263 
279 1 Y 1 B LEU 276 ? C LEU 264 
280 1 Y 1 B PRO 277 ? C PRO 265 
281 1 Y 1 B ALA 278 ? C ALA 266 
282 1 Y 1 B CYS 279 ? C CYS 267 
283 1 Y 1 B VAL 280 ? C VAL 268 
284 1 Y 1 B TYR 281 ? C TYR 269 
285 1 Y 1 B GLY 282 ? C GLY 270 
286 1 Y 1 B SER 283 ? C SER 271 
287 1 Y 1 B ALA 284 ? C ALA 272 
288 1 Y 1 B VAL 285 ? C VAL 273 
289 1 Y 1 B ALA 286 ? C ALA 274 
290 1 Y 1 B SER 287 ? C SER 275 
291 1 Y 1 B GLY 288 ? C GLY 276 
292 1 Y 1 B TYR 289 ? C TYR 277 
293 1 Y 1 B ASP 290 ? C ASP 278 
294 1 Y 1 B PHE 291 ? C PHE 279 
295 1 Y 1 B GLU 292 ? C GLU 280 
296 1 Y 1 B ARG 293 ? C ARG 281 
297 1 Y 1 B GLU 294 ? C GLU 282 
298 1 Y 1 B GLY 295 ? C GLY 283 
299 1 Y 1 B TYR 296 ? C TYR 284 
300 1 Y 1 B SER 297 ? C SER 285 
301 1 Y 1 B LEU 298 ? C LEU 286 
302 1 Y 1 B VAL 299 ? C VAL 287 
303 1 Y 1 B GLY 300 ? C GLY 288 
304 1 Y 1 B ILE 301 ? C ILE 289 
305 1 Y 1 B ASP 302 ? C ASP 290 
306 1 Y 1 B PRO 303 ? C PRO 291 
307 1 Y 1 B PHE 304 ? C PHE 292 
308 1 Y 1 B ARG 305 ? C ARG 293 
309 1 Y 1 B LEU 306 ? C LEU 294 
310 1 Y 1 B LEU 307 ? C LEU 295 
311 1 Y 1 B GLN 308 ? C GLN 296 
312 1 Y 1 B ASN 309 ? C ASN 297 
313 1 Y 1 B SER 310 ? C SER 298 
314 1 Y 1 B GLN 311 ? C GLN 299 
315 1 Y 1 B VAL 312 ? C VAL 300 
316 1 Y 1 B TYR 313 ? C TYR 301 
317 1 Y 1 B SER 314 ? C SER 302 
318 1 Y 1 B LEU 315 ? C LEU 303 
319 1 Y 1 B ILE 316 ? C ILE 304 
320 1 Y 1 B ARG 317 ? C ARG 305 
321 1 Y 1 B PRO 318 ? C PRO 306 
322 1 Y 1 B ASN 319 ? C ASN 307 
323 1 Y 1 B GLU 320 ? C GLU 308 
324 1 Y 1 B ASN 321 ? C ASN 309 
325 1 Y 1 B PRO 322 ? C PRO 310 
326 1 Y 1 B ALA 323 ? C ALA 311 
327 1 Y 1 B HIS 324 ? C HIS 312 
328 1 Y 1 B LYS 325 ? C LYS 313 
329 1 Y 1 B SER 326 ? C SER 314 
330 1 Y 1 B GLN 327 ? C GLN 315 
331 1 Y 1 B LEU 328 ? C LEU 316 
332 1 Y 1 B VAL 329 ? C VAL 317 
333 1 Y 1 B TRP 330 ? C TRP 318 
334 1 Y 1 B MET 331 ? C MET 319 
335 1 Y 1 B ALA 332 ? C ALA 320 
336 1 Y 1 B CYS 333 ? C CYS 321 
337 1 Y 1 B HIS 334 ? C HIS 322 
338 1 Y 1 B SER 335 ? C SER 323 
339 1 Y 1 B ALA 336 ? C ALA 324 
340 1 Y 1 B ALA 337 ? C ALA 325 
341 1 Y 1 B PHE 338 ? C PHE 326 
342 1 Y 1 B GLU 339 ? C GLU 327 
343 1 Y 1 B ASP 340 ? C ASP 328 
344 1 Y 1 B LEU 341 ? C LEU 329 
345 1 Y 1 B ARG 342 ? C ARG 330 
346 1 Y 1 B VAL 343 ? C VAL 331 
347 1 Y 1 B SER 344 ? C SER 332 
348 1 Y 1 B SER 345 ? C SER 333 
349 1 Y 1 B PHE 346 ? C PHE 334 
350 1 Y 1 B ILE 347 ? C ILE 335 
351 1 Y 1 B ARG 348 ? C ARG 336 
352 1 Y 1 B GLY 349 ? C GLY 337 
353 1 Y 1 B THR 350 ? C THR 338 
354 1 Y 1 B LYS 351 ? C LYS 339 
355 1 Y 1 B VAL 352 ? C VAL 340 
356 1 Y 1 B VAL 353 ? C VAL 341 
357 1 Y 1 B PRO 354 ? C PRO 342 
358 1 Y 1 B ARG 355 ? C ARG 343 
359 1 Y 1 B GLY 356 ? C GLY 344 
360 1 Y 1 B LYS 357 ? C LYS 345 
361 1 Y 1 B LEU 358 ? C LEU 346 
362 1 Y 1 B SER 359 ? C SER 347 
363 1 Y 1 B THR 360 ? C THR 348 
364 1 Y 1 B ARG 361 ? C ARG 349 
365 1 Y 1 B GLY 362 ? C GLY 350 
366 1 Y 1 B VAL 363 ? C VAL 351 
367 1 Y 1 B GLN 364 ? C GLN 352 
368 1 Y 1 B ILE 365 ? C ILE 353 
369 1 Y 1 B ALA 366 ? C ALA 354 
370 1 Y 1 B SER 367 ? C SER 355 
371 1 Y 1 B ASN 368 ? C ASN 356 
372 1 Y 1 B GLU 369 ? C GLU 357 
373 1 Y 1 B ASN 370 ? C ASN 358 
374 1 Y 1 B MET 371 ? C MET 359 
375 1 Y 1 B GLU 372 ? C GLU 360 
376 1 Y 1 B THR 373 ? C THR 361 
377 1 Y 1 B MET 374 ? C MET 362 
378 1 Y 1 B GLU 375 ? C GLU 363 
379 1 Y 1 B SER 376 ? C SER 364 
380 1 Y 1 B SER 377 ? C SER 365 
381 1 Y 1 B THR 378 ? C THR 366 
382 1 Y 1 B LEU 379 ? C LEU 367 
383 1 Y 1 B GLU 380 ? C GLU 368 
384 1 Y 1 B LEU 381 ? C LEU 369 
385 1 Y 1 B ARG 382 ? C ARG 370 
386 1 Y 1 B SER 383 ? C SER 371 
387 1 Y 1 B ARG 384 ? C ARG 372 
388 1 Y 1 B TYR 385 ? C TYR 373 
389 1 Y 1 B TRP 386 ? C TRP 374 
390 1 Y 1 B ALA 387 ? C ALA 375 
391 1 Y 1 B ILE 388 ? C ILE 376 
392 1 Y 1 B ARG 389 ? C ARG 377 
393 1 Y 1 B THR 390 ? C THR 378 
394 1 Y 1 B ARG 391 ? C ARG 379 
395 1 Y 1 B SER 392 ? C SER 380 
396 1 Y 1 B GLY 393 ? C GLY 381 
397 1 Y 1 B GLY 394 ? C GLY 382 
398 1 Y 1 B ASN 395 ? C ASN 383 
399 1 Y 1 B THR 396 ? C THR 384 
400 1 Y 1 B ASN 397 ? C ASN 385 
401 1 Y 1 B GLN 398 ? C GLN 386 
402 1 Y 1 B GLN 399 ? C GLN 387 
403 1 Y 1 B ARG 400 ? C ARG 388 
404 1 Y 1 B ALA 401 ? C ALA 389 
405 1 Y 1 B SER 402 ? C SER 390 
406 1 Y 1 B PHE 429 ? C PHE 417 
407 1 Y 1 B THR 430 ? C THR 418 
408 1 Y 1 B GLY 431 ? C GLY 419 
409 1 Y 1 B ASN 432 ? C ASN 420 
410 1 Y 1 B THR 433 ? C THR 421 
411 1 Y 1 B GLU 434 ? C GLU 422 
412 1 Y 1 B GLY 435 ? C GLY 423 
413 1 Y 1 B ARG 436 ? C ARG 424 
414 1 Y 1 B THR 437 ? C THR 425 
415 1 Y 1 B SER 438 ? C SER 426 
416 1 Y 1 B ASP 439 ? C ASP 427 
417 1 Y 1 B MET 440 ? C MET 428 
418 1 Y 1 B ARG 441 ? C ARG 429 
419 1 Y 1 B THR 442 ? C THR 430 
420 1 Y 1 B GLU 443 ? C GLU 431 
421 1 Y 1 B ILE 444 ? C ILE 432 
422 1 Y 1 B ILE 445 ? C ILE 433 
423 1 Y 1 B ARG 446 ? C ARG 434 
424 1 Y 1 B LEU 447 ? C LEU 435 
425 1 Y 1 B MET 448 ? C MET 436 
426 1 Y 1 B GLU 449 ? C GLU 437 
427 1 Y 1 B SER 450 ? C SER 438 
428 1 Y 1 B ALA 451 ? C ALA 439 
429 1 Y 1 B ARG 452 ? C ARG 440 
430 1 Y 1 B PRO 453 ? C PRO 441 
431 1 Y 1 B GLU 454 ? C GLU 442 
432 1 Y 1 B ASP 455 ? C ASP 443 
433 1 Y 1 B VAL 456 ? C VAL 444 
434 1 Y 1 B SER 457 ? C SER 445 
435 1 Y 1 B PHE 458 ? C PHE 446 
436 1 Y 1 B GLN 459 ? C GLN 447 
437 1 Y 1 B GLY 460 ? C GLY 448 
438 1 Y 1 B ARG 461 ? C ARG 449 
439 1 Y 1 B GLY 462 ? C GLY 450 
440 1 Y 1 B VAL 463 ? C VAL 451 
441 1 Y 1 B PHE 464 ? C PHE 452 
442 1 Y 1 B GLU 465 ? C GLU 453 
443 1 Y 1 B LEU 466 ? C LEU 454 
444 1 Y 1 B SER 467 ? C SER 455 
445 1 Y 1 B ASP 468 ? C ASP 456 
446 1 Y 1 B GLU 469 ? C GLU 457 
447 1 Y 1 B LYS 470 ? C LYS 458 
448 1 Y 1 B ALA 471 ? C ALA 459 
449 1 Y 1 B THR 472 ? C THR 460 
450 1 Y 1 B SER 473 ? C SER 461 
451 1 Y 1 B PRO 474 ? C PRO 462 
452 1 Y 1 B ILE 475 ? C ILE 463 
453 1 Y 1 B VAL 476 ? C VAL 464 
454 1 Y 1 B PRO 477 ? C PRO 465 
455 1 Y 1 B SER 478 ? C SER 466 
456 1 Y 1 B PHE 479 ? C PHE 467 
457 1 Y 1 B ASP 480 ? C ASP 468 
458 1 Y 1 B MET 481 ? C MET 469 
459 1 Y 1 B SER 482 ? C SER 470 
460 1 Y 1 B ASN 483 ? C ASN 471 
461 1 Y 1 B GLU 484 ? C GLU 472 
462 1 Y 1 B GLY 485 ? C GLY 473 
463 1 Y 1 B SER 486 ? C SER 474 
464 1 Y 1 B TYR 487 ? C TYR 475 
465 1 Y 1 B PHE 488 ? C PHE 476 
466 1 Y 1 B PHE 489 ? C PHE 477 
467 1 Y 1 B GLY 490 ? C GLY 478 
468 1 Y 1 B ASP 491 ? C ASP 479 
469 1 Y 1 B ASN 492 ? C ASN 480 
470 1 Y 1 B ALA 493 ? C ALA 481 
471 1 Y 1 B GLU 494 ? C GLU 482 
472 1 Y 1 B GLU 495 ? C GLU 483 
473 1 Y 1 B TYR 496 ? C TYR 484 
474 1 Y 1 B ASP 497 ? C ASP 485 
475 1 Y 1 B ASN 498 ? C ASN 486 
476 1 Y 1 B LEU 499 ? C LEU 487 
477 1 Y 1 B GLU 500 ? C GLU 488 
478 1 Y 1 B HIS 501 ? C HIS 489 
479 1 Y 1 B HIS 502 ? C HIS 490 
480 1 Y 1 B HIS 503 ? C HIS 491 
481 1 Y 1 B HIS 504 ? C HIS 492 
482 1 Y 1 B HIS 505 ? C HIS 493 
483 1 Y 1 B HIS 506 ? C HIS 494 
484 1 Y 1 A HIS 13  ? D HIS 1   
485 1 Y 1 A MET 14  ? D MET 2   
486 1 Y 1 A THR 15  ? D THR 3   
487 1 Y 1 A GLN 398 ? D GLN 386 
488 1 Y 1 A GLN 399 ? D GLN 387 
489 1 Y 1 A ARG 400 ? D ARG 388 
490 1 Y 1 A ALA 401 ? D ALA 389 
491 1 Y 1 A SER 402 ? D SER 390 
492 1 Y 1 A SER 403 ? D SER 391 
493 1 Y 1 A GLY 404 ? D GLY 392 
494 1 Y 1 A GLN 405 ? D GLN 393 
495 1 Y 1 A ILE 406 ? D ILE 394 
496 1 Y 1 A SER 407 ? D SER 395 
497 1 Y 1 A ILE 408 ? D ILE 396 
498 1 Y 1 A GLN 409 ? D GLN 397 
499 1 Y 1 A PRO 410 ? D PRO 398 
500 1 Y 1 A THR 411 ? D THR 399 
501 1 Y 1 A PHE 412 ? D PHE 400 
502 1 Y 1 A SER 413 ? D SER 401 
503 1 Y 1 A VAL 414 ? D VAL 402 
504 1 Y 1 A GLN 415 ? D GLN 403 
505 1 Y 1 A ARG 416 ? D ARG 404 
506 1 Y 1 A ASN 417 ? D ASN 405 
507 1 Y 1 A LEU 418 ? D LEU 406 
508 1 Y 1 A PRO 419 ? D PRO 407 
509 1 Y 1 A PHE 420 ? D PHE 408 
510 1 Y 1 A ASP 421 ? D ASP 409 
511 1 Y 1 A ARG 422 ? D ARG 410 
512 1 Y 1 A PRO 423 ? D PRO 411 
513 1 Y 1 A THR 424 ? D THR 412 
514 1 Y 1 A ILE 425 ? D ILE 413 
515 1 Y 1 A MET 426 ? D MET 414 
516 1 Y 1 A ALA 427 ? D ALA 415 
517 1 Y 1 A ALA 428 ? D ALA 416 
518 1 Y 1 A PHE 429 ? D PHE 417 
519 1 Y 1 A THR 430 ? D THR 418 
520 1 Y 1 A GLY 431 ? D GLY 419 
521 1 Y 1 A ASN 432 ? D ASN 420 
522 1 Y 1 A THR 433 ? D THR 421 
523 1 Y 1 A GLU 434 ? D GLU 422 
524 1 Y 1 A GLY 435 ? D GLY 423 
525 1 Y 1 A ARG 436 ? D ARG 424 
526 1 Y 1 A THR 437 ? D THR 425 
527 1 Y 1 A SER 438 ? D SER 426 
528 1 Y 1 A ASP 480 ? D ASP 468 
529 1 Y 1 A MET 481 ? D MET 469 
530 1 Y 1 A SER 482 ? D SER 470 
531 1 Y 1 A ASN 483 ? D ASN 471 
532 1 Y 1 A ASP 491 ? D ASP 479 
533 1 Y 1 A ASN 492 ? D ASN 480 
534 1 Y 1 A ALA 493 ? D ALA 481 
535 1 Y 1 A GLU 494 ? D GLU 482 
536 1 Y 1 A GLU 495 ? D GLU 483 
537 1 Y 1 A TYR 496 ? D TYR 484 
538 1 Y 1 A ASP 497 ? D ASP 485 
539 1 Y 1 A ASN 498 ? D ASN 486 
540 1 Y 1 A LEU 499 ? D LEU 487 
541 1 Y 1 A GLU 500 ? D GLU 488 
542 1 Y 1 A HIS 501 ? D HIS 489 
543 1 Y 1 A HIS 502 ? D HIS 490 
544 1 Y 1 A HIS 503 ? D HIS 491 
545 1 Y 1 A HIS 504 ? D HIS 492 
546 1 Y 1 A HIS 505 ? D HIS 493 
547 1 Y 1 A HIS 506 ? D HIS 494 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N      N N N 1   
ALA CA     C N S 2   
ALA C      C N N 3   
ALA O      O N N 4   
ALA CB     C N N 5   
ALA OXT    O N N 6   
ALA H      H N N 7   
ALA H2     H N N 8   
ALA HA     H N N 9   
ALA HB1    H N N 10  
ALA HB2    H N N 11  
ALA HB3    H N N 12  
ALA HXT    H N N 13  
ARG N      N N N 14  
ARG CA     C N S 15  
ARG C      C N N 16  
ARG O      O N N 17  
ARG CB     C N N 18  
ARG CG     C N N 19  
ARG CD     C N N 20  
ARG NE     N N N 21  
ARG CZ     C N N 22  
ARG NH1    N N N 23  
ARG NH2    N N N 24  
ARG OXT    O N N 25  
ARG H      H N N 26  
ARG H2     H N N 27  
ARG HA     H N N 28  
ARG HB2    H N N 29  
ARG HB3    H N N 30  
ARG HG2    H N N 31  
ARG HG3    H N N 32  
ARG HD2    H N N 33  
ARG HD3    H N N 34  
ARG HE     H N N 35  
ARG HH11   H N N 36  
ARG HH12   H N N 37  
ARG HH21   H N N 38  
ARG HH22   H N N 39  
ARG HXT    H N N 40  
ASN N      N N N 41  
ASN CA     C N S 42  
ASN C      C N N 43  
ASN O      O N N 44  
ASN CB     C N N 45  
ASN CG     C N N 46  
ASN OD1    O N N 47  
ASN ND2    N N N 48  
ASN OXT    O N N 49  
ASN H      H N N 50  
ASN H2     H N N 51  
ASN HA     H N N 52  
ASN HB2    H N N 53  
ASN HB3    H N N 54  
ASN HD21   H N N 55  
ASN HD22   H N N 56  
ASN HXT    H N N 57  
ASP N      N N N 58  
ASP CA     C N S 59  
ASP C      C N N 60  
ASP O      O N N 61  
ASP CB     C N N 62  
ASP CG     C N N 63  
ASP OD1    O N N 64  
ASP OD2    O N N 65  
ASP OXT    O N N 66  
ASP H      H N N 67  
ASP H2     H N N 68  
ASP HA     H N N 69  
ASP HB2    H N N 70  
ASP HB3    H N N 71  
ASP HD2    H N N 72  
ASP HXT    H N N 73  
C   OP3    O N N 74  
C   P      P N N 75  
C   OP1    O N N 76  
C   OP2    O N N 77  
C   "O5'"  O N N 78  
C   "C5'"  C N N 79  
C   "C4'"  C N R 80  
C   "O4'"  O N N 81  
C   "C3'"  C N S 82  
C   "O3'"  O N N 83  
C   "C2'"  C N R 84  
C   "O2'"  O N N 85  
C   "C1'"  C N R 86  
C   N1     N N N 87  
C   C2     C N N 88  
C   O2     O N N 89  
C   N3     N N N 90  
C   C4     C N N 91  
C   N4     N N N 92  
C   C5     C N N 93  
C   C6     C N N 94  
C   HOP3   H N N 95  
C   HOP2   H N N 96  
C   "H5'"  H N N 97  
C   "H5''" H N N 98  
C   "H4'"  H N N 99  
C   "H3'"  H N N 100 
C   "HO3'" H N N 101 
C   "H2'"  H N N 102 
C   "HO2'" H N N 103 
C   "H1'"  H N N 104 
C   H41    H N N 105 
C   H42    H N N 106 
C   H5     H N N 107 
C   H6     H N N 108 
CYS N      N N N 109 
CYS CA     C N R 110 
CYS C      C N N 111 
CYS O      O N N 112 
CYS CB     C N N 113 
CYS SG     S N N 114 
CYS OXT    O N N 115 
CYS H      H N N 116 
CYS H2     H N N 117 
CYS HA     H N N 118 
CYS HB2    H N N 119 
CYS HB3    H N N 120 
CYS HG     H N N 121 
CYS HXT    H N N 122 
GLN N      N N N 123 
GLN CA     C N S 124 
GLN C      C N N 125 
GLN O      O N N 126 
GLN CB     C N N 127 
GLN CG     C N N 128 
GLN CD     C N N 129 
GLN OE1    O N N 130 
GLN NE2    N N N 131 
GLN OXT    O N N 132 
GLN H      H N N 133 
GLN H2     H N N 134 
GLN HA     H N N 135 
GLN HB2    H N N 136 
GLN HB3    H N N 137 
GLN HG2    H N N 138 
GLN HG3    H N N 139 
GLN HE21   H N N 140 
GLN HE22   H N N 141 
GLN HXT    H N N 142 
GLU N      N N N 143 
GLU CA     C N S 144 
GLU C      C N N 145 
GLU O      O N N 146 
GLU CB     C N N 147 
GLU CG     C N N 148 
GLU CD     C N N 149 
GLU OE1    O N N 150 
GLU OE2    O N N 151 
GLU OXT    O N N 152 
GLU H      H N N 153 
GLU H2     H N N 154 
GLU HA     H N N 155 
GLU HB2    H N N 156 
GLU HB3    H N N 157 
GLU HG2    H N N 158 
GLU HG3    H N N 159 
GLU HE2    H N N 160 
GLU HXT    H N N 161 
GLY N      N N N 162 
GLY CA     C N N 163 
GLY C      C N N 164 
GLY O      O N N 165 
GLY OXT    O N N 166 
GLY H      H N N 167 
GLY H2     H N N 168 
GLY HA2    H N N 169 
GLY HA3    H N N 170 
GLY HXT    H N N 171 
HIS N      N N N 172 
HIS CA     C N S 173 
HIS C      C N N 174 
HIS O      O N N 175 
HIS CB     C N N 176 
HIS CG     C Y N 177 
HIS ND1    N Y N 178 
HIS CD2    C Y N 179 
HIS CE1    C Y N 180 
HIS NE2    N Y N 181 
HIS OXT    O N N 182 
HIS H      H N N 183 
HIS H2     H N N 184 
HIS HA     H N N 185 
HIS HB2    H N N 186 
HIS HB3    H N N 187 
HIS HD1    H N N 188 
HIS HD2    H N N 189 
HIS HE1    H N N 190 
HIS HE2    H N N 191 
HIS HXT    H N N 192 
ILE N      N N N 193 
ILE CA     C N S 194 
ILE C      C N N 195 
ILE O      O N N 196 
ILE CB     C N S 197 
ILE CG1    C N N 198 
ILE CG2    C N N 199 
ILE CD1    C N N 200 
ILE OXT    O N N 201 
ILE H      H N N 202 
ILE H2     H N N 203 
ILE HA     H N N 204 
ILE HB     H N N 205 
ILE HG12   H N N 206 
ILE HG13   H N N 207 
ILE HG21   H N N 208 
ILE HG22   H N N 209 
ILE HG23   H N N 210 
ILE HD11   H N N 211 
ILE HD12   H N N 212 
ILE HD13   H N N 213 
ILE HXT    H N N 214 
LEU N      N N N 215 
LEU CA     C N S 216 
LEU C      C N N 217 
LEU O      O N N 218 
LEU CB     C N N 219 
LEU CG     C N N 220 
LEU CD1    C N N 221 
LEU CD2    C N N 222 
LEU OXT    O N N 223 
LEU H      H N N 224 
LEU H2     H N N 225 
LEU HA     H N N 226 
LEU HB2    H N N 227 
LEU HB3    H N N 228 
LEU HG     H N N 229 
LEU HD11   H N N 230 
LEU HD12   H N N 231 
LEU HD13   H N N 232 
LEU HD21   H N N 233 
LEU HD22   H N N 234 
LEU HD23   H N N 235 
LEU HXT    H N N 236 
LYS N      N N N 237 
LYS CA     C N S 238 
LYS C      C N N 239 
LYS O      O N N 240 
LYS CB     C N N 241 
LYS CG     C N N 242 
LYS CD     C N N 243 
LYS CE     C N N 244 
LYS NZ     N N N 245 
LYS OXT    O N N 246 
LYS H      H N N 247 
LYS H2     H N N 248 
LYS HA     H N N 249 
LYS HB2    H N N 250 
LYS HB3    H N N 251 
LYS HG2    H N N 252 
LYS HG3    H N N 253 
LYS HD2    H N N 254 
LYS HD3    H N N 255 
LYS HE2    H N N 256 
LYS HE3    H N N 257 
LYS HZ1    H N N 258 
LYS HZ2    H N N 259 
LYS HZ3    H N N 260 
LYS HXT    H N N 261 
MET N      N N N 262 
MET CA     C N S 263 
MET C      C N N 264 
MET O      O N N 265 
MET CB     C N N 266 
MET CG     C N N 267 
MET SD     S N N 268 
MET CE     C N N 269 
MET OXT    O N N 270 
MET H      H N N 271 
MET H2     H N N 272 
MET HA     H N N 273 
MET HB2    H N N 274 
MET HB3    H N N 275 
MET HG2    H N N 276 
MET HG3    H N N 277 
MET HE1    H N N 278 
MET HE2    H N N 279 
MET HE3    H N N 280 
MET HXT    H N N 281 
PHE N      N N N 282 
PHE CA     C N S 283 
PHE C      C N N 284 
PHE O      O N N 285 
PHE CB     C N N 286 
PHE CG     C Y N 287 
PHE CD1    C Y N 288 
PHE CD2    C Y N 289 
PHE CE1    C Y N 290 
PHE CE2    C Y N 291 
PHE CZ     C Y N 292 
PHE OXT    O N N 293 
PHE H      H N N 294 
PHE H2     H N N 295 
PHE HA     H N N 296 
PHE HB2    H N N 297 
PHE HB3    H N N 298 
PHE HD1    H N N 299 
PHE HD2    H N N 300 
PHE HE1    H N N 301 
PHE HE2    H N N 302 
PHE HZ     H N N 303 
PHE HXT    H N N 304 
PRO N      N N N 305 
PRO CA     C N S 306 
PRO C      C N N 307 
PRO O      O N N 308 
PRO CB     C N N 309 
PRO CG     C N N 310 
PRO CD     C N N 311 
PRO OXT    O N N 312 
PRO H      H N N 313 
PRO HA     H N N 314 
PRO HB2    H N N 315 
PRO HB3    H N N 316 
PRO HG2    H N N 317 
PRO HG3    H N N 318 
PRO HD2    H N N 319 
PRO HD3    H N N 320 
PRO HXT    H N N 321 
SER N      N N N 322 
SER CA     C N S 323 
SER C      C N N 324 
SER O      O N N 325 
SER CB     C N N 326 
SER OG     O N N 327 
SER OXT    O N N 328 
SER H      H N N 329 
SER H2     H N N 330 
SER HA     H N N 331 
SER HB2    H N N 332 
SER HB3    H N N 333 
SER HG     H N N 334 
SER HXT    H N N 335 
THR N      N N N 336 
THR CA     C N S 337 
THR C      C N N 338 
THR O      O N N 339 
THR CB     C N R 340 
THR OG1    O N N 341 
THR CG2    C N N 342 
THR OXT    O N N 343 
THR H      H N N 344 
THR H2     H N N 345 
THR HA     H N N 346 
THR HB     H N N 347 
THR HG1    H N N 348 
THR HG21   H N N 349 
THR HG22   H N N 350 
THR HG23   H N N 351 
THR HXT    H N N 352 
TRP N      N N N 353 
TRP CA     C N S 354 
TRP C      C N N 355 
TRP O      O N N 356 
TRP CB     C N N 357 
TRP CG     C Y N 358 
TRP CD1    C Y N 359 
TRP CD2    C Y N 360 
TRP NE1    N Y N 361 
TRP CE2    C Y N 362 
TRP CE3    C Y N 363 
TRP CZ2    C Y N 364 
TRP CZ3    C Y N 365 
TRP CH2    C Y N 366 
TRP OXT    O N N 367 
TRP H      H N N 368 
TRP H2     H N N 369 
TRP HA     H N N 370 
TRP HB2    H N N 371 
TRP HB3    H N N 372 
TRP HD1    H N N 373 
TRP HE1    H N N 374 
TRP HE3    H N N 375 
TRP HZ2    H N N 376 
TRP HZ3    H N N 377 
TRP HH2    H N N 378 
TRP HXT    H N N 379 
TYR N      N N N 380 
TYR CA     C N S 381 
TYR C      C N N 382 
TYR O      O N N 383 
TYR CB     C N N 384 
TYR CG     C Y N 385 
TYR CD1    C Y N 386 
TYR CD2    C Y N 387 
TYR CE1    C Y N 388 
TYR CE2    C Y N 389 
TYR CZ     C Y N 390 
TYR OH     O N N 391 
TYR OXT    O N N 392 
TYR H      H N N 393 
TYR H2     H N N 394 
TYR HA     H N N 395 
TYR HB2    H N N 396 
TYR HB3    H N N 397 
TYR HD1    H N N 398 
TYR HD2    H N N 399 
TYR HE1    H N N 400 
TYR HE2    H N N 401 
TYR HH     H N N 402 
TYR HXT    H N N 403 
U   OP3    O N N 404 
U   P      P N N 405 
U   OP1    O N N 406 
U   OP2    O N N 407 
U   "O5'"  O N N 408 
U   "C5'"  C N N 409 
U   "C4'"  C N R 410 
U   "O4'"  O N N 411 
U   "C3'"  C N S 412 
U   "O3'"  O N N 413 
U   "C2'"  C N R 414 
U   "O2'"  O N N 415 
U   "C1'"  C N R 416 
U   N1     N N N 417 
U   C2     C N N 418 
U   O2     O N N 419 
U   N3     N N N 420 
U   C4     C N N 421 
U   O4     O N N 422 
U   C5     C N N 423 
U   C6     C N N 424 
U   HOP3   H N N 425 
U   HOP2   H N N 426 
U   "H5'"  H N N 427 
U   "H5''" H N N 428 
U   "H4'"  H N N 429 
U   "H3'"  H N N 430 
U   "HO3'" H N N 431 
U   "H2'"  H N N 432 
U   "HO2'" H N N 433 
U   "H1'"  H N N 434 
U   H3     H N N 435 
U   H5     H N N 436 
U   H6     H N N 437 
VAL N      N N N 438 
VAL CA     C N S 439 
VAL C      C N N 440 
VAL O      O N N 441 
VAL CB     C N N 442 
VAL CG1    C N N 443 
VAL CG2    C N N 444 
VAL OXT    O N N 445 
VAL H      H N N 446 
VAL H2     H N N 447 
VAL HA     H N N 448 
VAL HB     H N N 449 
VAL HG11   H N N 450 
VAL HG12   H N N 451 
VAL HG13   H N N 452 
VAL HG21   H N N 453 
VAL HG22   H N N 454 
VAL HG23   H N N 455 
VAL HXT    H N N 456 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N     CA     sing N N 1   
ALA N     H      sing N N 2   
ALA N     H2     sing N N 3   
ALA CA    C      sing N N 4   
ALA CA    CB     sing N N 5   
ALA CA    HA     sing N N 6   
ALA C     O      doub N N 7   
ALA C     OXT    sing N N 8   
ALA CB    HB1    sing N N 9   
ALA CB    HB2    sing N N 10  
ALA CB    HB3    sing N N 11  
ALA OXT   HXT    sing N N 12  
ARG N     CA     sing N N 13  
ARG N     H      sing N N 14  
ARG N     H2     sing N N 15  
ARG CA    C      sing N N 16  
ARG CA    CB     sing N N 17  
ARG CA    HA     sing N N 18  
ARG C     O      doub N N 19  
ARG C     OXT    sing N N 20  
ARG CB    CG     sing N N 21  
ARG CB    HB2    sing N N 22  
ARG CB    HB3    sing N N 23  
ARG CG    CD     sing N N 24  
ARG CG    HG2    sing N N 25  
ARG CG    HG3    sing N N 26  
ARG CD    NE     sing N N 27  
ARG CD    HD2    sing N N 28  
ARG CD    HD3    sing N N 29  
ARG NE    CZ     sing N N 30  
ARG NE    HE     sing N N 31  
ARG CZ    NH1    sing N N 32  
ARG CZ    NH2    doub N N 33  
ARG NH1   HH11   sing N N 34  
ARG NH1   HH12   sing N N 35  
ARG NH2   HH21   sing N N 36  
ARG NH2   HH22   sing N N 37  
ARG OXT   HXT    sing N N 38  
ASN N     CA     sing N N 39  
ASN N     H      sing N N 40  
ASN N     H2     sing N N 41  
ASN CA    C      sing N N 42  
ASN CA    CB     sing N N 43  
ASN CA    HA     sing N N 44  
ASN C     O      doub N N 45  
ASN C     OXT    sing N N 46  
ASN CB    CG     sing N N 47  
ASN CB    HB2    sing N N 48  
ASN CB    HB3    sing N N 49  
ASN CG    OD1    doub N N 50  
ASN CG    ND2    sing N N 51  
ASN ND2   HD21   sing N N 52  
ASN ND2   HD22   sing N N 53  
ASN OXT   HXT    sing N N 54  
ASP N     CA     sing N N 55  
ASP N     H      sing N N 56  
ASP N     H2     sing N N 57  
ASP CA    C      sing N N 58  
ASP CA    CB     sing N N 59  
ASP CA    HA     sing N N 60  
ASP C     O      doub N N 61  
ASP C     OXT    sing N N 62  
ASP CB    CG     sing N N 63  
ASP CB    HB2    sing N N 64  
ASP CB    HB3    sing N N 65  
ASP CG    OD1    doub N N 66  
ASP CG    OD2    sing N N 67  
ASP OD2   HD2    sing N N 68  
ASP OXT   HXT    sing N N 69  
C   OP3   P      sing N N 70  
C   OP3   HOP3   sing N N 71  
C   P     OP1    doub N N 72  
C   P     OP2    sing N N 73  
C   P     "O5'"  sing N N 74  
C   OP2   HOP2   sing N N 75  
C   "O5'" "C5'"  sing N N 76  
C   "C5'" "C4'"  sing N N 77  
C   "C5'" "H5'"  sing N N 78  
C   "C5'" "H5''" sing N N 79  
C   "C4'" "O4'"  sing N N 80  
C   "C4'" "C3'"  sing N N 81  
C   "C4'" "H4'"  sing N N 82  
C   "O4'" "C1'"  sing N N 83  
C   "C3'" "O3'"  sing N N 84  
C   "C3'" "C2'"  sing N N 85  
C   "C3'" "H3'"  sing N N 86  
C   "O3'" "HO3'" sing N N 87  
C   "C2'" "O2'"  sing N N 88  
C   "C2'" "C1'"  sing N N 89  
C   "C2'" "H2'"  sing N N 90  
C   "O2'" "HO2'" sing N N 91  
C   "C1'" N1     sing N N 92  
C   "C1'" "H1'"  sing N N 93  
C   N1    C2     sing N N 94  
C   N1    C6     sing N N 95  
C   C2    O2     doub N N 96  
C   C2    N3     sing N N 97  
C   N3    C4     doub N N 98  
C   C4    N4     sing N N 99  
C   C4    C5     sing N N 100 
C   N4    H41    sing N N 101 
C   N4    H42    sing N N 102 
C   C5    C6     doub N N 103 
C   C5    H5     sing N N 104 
C   C6    H6     sing N N 105 
CYS N     CA     sing N N 106 
CYS N     H      sing N N 107 
CYS N     H2     sing N N 108 
CYS CA    C      sing N N 109 
CYS CA    CB     sing N N 110 
CYS CA    HA     sing N N 111 
CYS C     O      doub N N 112 
CYS C     OXT    sing N N 113 
CYS CB    SG     sing N N 114 
CYS CB    HB2    sing N N 115 
CYS CB    HB3    sing N N 116 
CYS SG    HG     sing N N 117 
CYS OXT   HXT    sing N N 118 
GLN N     CA     sing N N 119 
GLN N     H      sing N N 120 
GLN N     H2     sing N N 121 
GLN CA    C      sing N N 122 
GLN CA    CB     sing N N 123 
GLN CA    HA     sing N N 124 
GLN C     O      doub N N 125 
GLN C     OXT    sing N N 126 
GLN CB    CG     sing N N 127 
GLN CB    HB2    sing N N 128 
GLN CB    HB3    sing N N 129 
GLN CG    CD     sing N N 130 
GLN CG    HG2    sing N N 131 
GLN CG    HG3    sing N N 132 
GLN CD    OE1    doub N N 133 
GLN CD    NE2    sing N N 134 
GLN NE2   HE21   sing N N 135 
GLN NE2   HE22   sing N N 136 
GLN OXT   HXT    sing N N 137 
GLU N     CA     sing N N 138 
GLU N     H      sing N N 139 
GLU N     H2     sing N N 140 
GLU CA    C      sing N N 141 
GLU CA    CB     sing N N 142 
GLU CA    HA     sing N N 143 
GLU C     O      doub N N 144 
GLU C     OXT    sing N N 145 
GLU CB    CG     sing N N 146 
GLU CB    HB2    sing N N 147 
GLU CB    HB3    sing N N 148 
GLU CG    CD     sing N N 149 
GLU CG    HG2    sing N N 150 
GLU CG    HG3    sing N N 151 
GLU CD    OE1    doub N N 152 
GLU CD    OE2    sing N N 153 
GLU OE2   HE2    sing N N 154 
GLU OXT   HXT    sing N N 155 
GLY N     CA     sing N N 156 
GLY N     H      sing N N 157 
GLY N     H2     sing N N 158 
GLY CA    C      sing N N 159 
GLY CA    HA2    sing N N 160 
GLY CA    HA3    sing N N 161 
GLY C     O      doub N N 162 
GLY C     OXT    sing N N 163 
GLY OXT   HXT    sing N N 164 
HIS N     CA     sing N N 165 
HIS N     H      sing N N 166 
HIS N     H2     sing N N 167 
HIS CA    C      sing N N 168 
HIS CA    CB     sing N N 169 
HIS CA    HA     sing N N 170 
HIS C     O      doub N N 171 
HIS C     OXT    sing N N 172 
HIS CB    CG     sing N N 173 
HIS CB    HB2    sing N N 174 
HIS CB    HB3    sing N N 175 
HIS CG    ND1    sing Y N 176 
HIS CG    CD2    doub Y N 177 
HIS ND1   CE1    doub Y N 178 
HIS ND1   HD1    sing N N 179 
HIS CD2   NE2    sing Y N 180 
HIS CD2   HD2    sing N N 181 
HIS CE1   NE2    sing Y N 182 
HIS CE1   HE1    sing N N 183 
HIS NE2   HE2    sing N N 184 
HIS OXT   HXT    sing N N 185 
ILE N     CA     sing N N 186 
ILE N     H      sing N N 187 
ILE N     H2     sing N N 188 
ILE CA    C      sing N N 189 
ILE CA    CB     sing N N 190 
ILE CA    HA     sing N N 191 
ILE C     O      doub N N 192 
ILE C     OXT    sing N N 193 
ILE CB    CG1    sing N N 194 
ILE CB    CG2    sing N N 195 
ILE CB    HB     sing N N 196 
ILE CG1   CD1    sing N N 197 
ILE CG1   HG12   sing N N 198 
ILE CG1   HG13   sing N N 199 
ILE CG2   HG21   sing N N 200 
ILE CG2   HG22   sing N N 201 
ILE CG2   HG23   sing N N 202 
ILE CD1   HD11   sing N N 203 
ILE CD1   HD12   sing N N 204 
ILE CD1   HD13   sing N N 205 
ILE OXT   HXT    sing N N 206 
LEU N     CA     sing N N 207 
LEU N     H      sing N N 208 
LEU N     H2     sing N N 209 
LEU CA    C      sing N N 210 
LEU CA    CB     sing N N 211 
LEU CA    HA     sing N N 212 
LEU C     O      doub N N 213 
LEU C     OXT    sing N N 214 
LEU CB    CG     sing N N 215 
LEU CB    HB2    sing N N 216 
LEU CB    HB3    sing N N 217 
LEU CG    CD1    sing N N 218 
LEU CG    CD2    sing N N 219 
LEU CG    HG     sing N N 220 
LEU CD1   HD11   sing N N 221 
LEU CD1   HD12   sing N N 222 
LEU CD1   HD13   sing N N 223 
LEU CD2   HD21   sing N N 224 
LEU CD2   HD22   sing N N 225 
LEU CD2   HD23   sing N N 226 
LEU OXT   HXT    sing N N 227 
LYS N     CA     sing N N 228 
LYS N     H      sing N N 229 
LYS N     H2     sing N N 230 
LYS CA    C      sing N N 231 
LYS CA    CB     sing N N 232 
LYS CA    HA     sing N N 233 
LYS C     O      doub N N 234 
LYS C     OXT    sing N N 235 
LYS CB    CG     sing N N 236 
LYS CB    HB2    sing N N 237 
LYS CB    HB3    sing N N 238 
LYS CG    CD     sing N N 239 
LYS CG    HG2    sing N N 240 
LYS CG    HG3    sing N N 241 
LYS CD    CE     sing N N 242 
LYS CD    HD2    sing N N 243 
LYS CD    HD3    sing N N 244 
LYS CE    NZ     sing N N 245 
LYS CE    HE2    sing N N 246 
LYS CE    HE3    sing N N 247 
LYS NZ    HZ1    sing N N 248 
LYS NZ    HZ2    sing N N 249 
LYS NZ    HZ3    sing N N 250 
LYS OXT   HXT    sing N N 251 
MET N     CA     sing N N 252 
MET N     H      sing N N 253 
MET N     H2     sing N N 254 
MET CA    C      sing N N 255 
MET CA    CB     sing N N 256 
MET CA    HA     sing N N 257 
MET C     O      doub N N 258 
MET C     OXT    sing N N 259 
MET CB    CG     sing N N 260 
MET CB    HB2    sing N N 261 
MET CB    HB3    sing N N 262 
MET CG    SD     sing N N 263 
MET CG    HG2    sing N N 264 
MET CG    HG3    sing N N 265 
MET SD    CE     sing N N 266 
MET CE    HE1    sing N N 267 
MET CE    HE2    sing N N 268 
MET CE    HE3    sing N N 269 
MET OXT   HXT    sing N N 270 
PHE N     CA     sing N N 271 
PHE N     H      sing N N 272 
PHE N     H2     sing N N 273 
PHE CA    C      sing N N 274 
PHE CA    CB     sing N N 275 
PHE CA    HA     sing N N 276 
PHE C     O      doub N N 277 
PHE C     OXT    sing N N 278 
PHE CB    CG     sing N N 279 
PHE CB    HB2    sing N N 280 
PHE CB    HB3    sing N N 281 
PHE CG    CD1    doub Y N 282 
PHE CG    CD2    sing Y N 283 
PHE CD1   CE1    sing Y N 284 
PHE CD1   HD1    sing N N 285 
PHE CD2   CE2    doub Y N 286 
PHE CD2   HD2    sing N N 287 
PHE CE1   CZ     doub Y N 288 
PHE CE1   HE1    sing N N 289 
PHE CE2   CZ     sing Y N 290 
PHE CE2   HE2    sing N N 291 
PHE CZ    HZ     sing N N 292 
PHE OXT   HXT    sing N N 293 
PRO N     CA     sing N N 294 
PRO N     CD     sing N N 295 
PRO N     H      sing N N 296 
PRO CA    C      sing N N 297 
PRO CA    CB     sing N N 298 
PRO CA    HA     sing N N 299 
PRO C     O      doub N N 300 
PRO C     OXT    sing N N 301 
PRO CB    CG     sing N N 302 
PRO CB    HB2    sing N N 303 
PRO CB    HB3    sing N N 304 
PRO CG    CD     sing N N 305 
PRO CG    HG2    sing N N 306 
PRO CG    HG3    sing N N 307 
PRO CD    HD2    sing N N 308 
PRO CD    HD3    sing N N 309 
PRO OXT   HXT    sing N N 310 
SER N     CA     sing N N 311 
SER N     H      sing N N 312 
SER N     H2     sing N N 313 
SER CA    C      sing N N 314 
SER CA    CB     sing N N 315 
SER CA    HA     sing N N 316 
SER C     O      doub N N 317 
SER C     OXT    sing N N 318 
SER CB    OG     sing N N 319 
SER CB    HB2    sing N N 320 
SER CB    HB3    sing N N 321 
SER OG    HG     sing N N 322 
SER OXT   HXT    sing N N 323 
THR N     CA     sing N N 324 
THR N     H      sing N N 325 
THR N     H2     sing N N 326 
THR CA    C      sing N N 327 
THR CA    CB     sing N N 328 
THR CA    HA     sing N N 329 
THR C     O      doub N N 330 
THR C     OXT    sing N N 331 
THR CB    OG1    sing N N 332 
THR CB    CG2    sing N N 333 
THR CB    HB     sing N N 334 
THR OG1   HG1    sing N N 335 
THR CG2   HG21   sing N N 336 
THR CG2   HG22   sing N N 337 
THR CG2   HG23   sing N N 338 
THR OXT   HXT    sing N N 339 
TRP N     CA     sing N N 340 
TRP N     H      sing N N 341 
TRP N     H2     sing N N 342 
TRP CA    C      sing N N 343 
TRP CA    CB     sing N N 344 
TRP CA    HA     sing N N 345 
TRP C     O      doub N N 346 
TRP C     OXT    sing N N 347 
TRP CB    CG     sing N N 348 
TRP CB    HB2    sing N N 349 
TRP CB    HB3    sing N N 350 
TRP CG    CD1    doub Y N 351 
TRP CG    CD2    sing Y N 352 
TRP CD1   NE1    sing Y N 353 
TRP CD1   HD1    sing N N 354 
TRP CD2   CE2    doub Y N 355 
TRP CD2   CE3    sing Y N 356 
TRP NE1   CE2    sing Y N 357 
TRP NE1   HE1    sing N N 358 
TRP CE2   CZ2    sing Y N 359 
TRP CE3   CZ3    doub Y N 360 
TRP CE3   HE3    sing N N 361 
TRP CZ2   CH2    doub Y N 362 
TRP CZ2   HZ2    sing N N 363 
TRP CZ3   CH2    sing Y N 364 
TRP CZ3   HZ3    sing N N 365 
TRP CH2   HH2    sing N N 366 
TRP OXT   HXT    sing N N 367 
TYR N     CA     sing N N 368 
TYR N     H      sing N N 369 
TYR N     H2     sing N N 370 
TYR CA    C      sing N N 371 
TYR CA    CB     sing N N 372 
TYR CA    HA     sing N N 373 
TYR C     O      doub N N 374 
TYR C     OXT    sing N N 375 
TYR CB    CG     sing N N 376 
TYR CB    HB2    sing N N 377 
TYR CB    HB3    sing N N 378 
TYR CG    CD1    doub Y N 379 
TYR CG    CD2    sing Y N 380 
TYR CD1   CE1    sing Y N 381 
TYR CD1   HD1    sing N N 382 
TYR CD2   CE2    doub Y N 383 
TYR CD2   HD2    sing N N 384 
TYR CE1   CZ     doub Y N 385 
TYR CE1   HE1    sing N N 386 
TYR CE2   CZ     sing Y N 387 
TYR CE2   HE2    sing N N 388 
TYR CZ    OH     sing N N 389 
TYR OH    HH     sing N N 390 
TYR OXT   HXT    sing N N 391 
U   OP3   P      sing N N 392 
U   OP3   HOP3   sing N N 393 
U   P     OP1    doub N N 394 
U   P     OP2    sing N N 395 
U   P     "O5'"  sing N N 396 
U   OP2   HOP2   sing N N 397 
U   "O5'" "C5'"  sing N N 398 
U   "C5'" "C4'"  sing N N 399 
U   "C5'" "H5'"  sing N N 400 
U   "C5'" "H5''" sing N N 401 
U   "C4'" "O4'"  sing N N 402 
U   "C4'" "C3'"  sing N N 403 
U   "C4'" "H4'"  sing N N 404 
U   "O4'" "C1'"  sing N N 405 
U   "C3'" "O3'"  sing N N 406 
U   "C3'" "C2'"  sing N N 407 
U   "C3'" "H3'"  sing N N 408 
U   "O3'" "HO3'" sing N N 409 
U   "C2'" "O2'"  sing N N 410 
U   "C2'" "C1'"  sing N N 411 
U   "C2'" "H2'"  sing N N 412 
U   "O2'" "HO2'" sing N N 413 
U   "C1'" N1     sing N N 414 
U   "C1'" "H1'"  sing N N 415 
U   N1    C2     sing N N 416 
U   N1    C6     sing N N 417 
U   C2    O2     doub N N 418 
U   C2    N3     sing N N 419 
U   N3    C4     sing N N 420 
U   N3    H3     sing N N 421 
U   C4    O4     doub N N 422 
U   C4    C5     sing N N 423 
U   C5    C6     doub N N 424 
U   C5    H5     sing N N 425 
U   C6    H6     sing N N 426 
VAL N     CA     sing N N 427 
VAL N     H      sing N N 428 
VAL N     H2     sing N N 429 
VAL CA    C      sing N N 430 
VAL CA    CB     sing N N 431 
VAL CA    HA     sing N N 432 
VAL C     O      doub N N 433 
VAL C     OXT    sing N N 434 
VAL CB    CG1    sing N N 435 
VAL CB    CG2    sing N N 436 
VAL CB    HB     sing N N 437 
VAL CG1   HG11   sing N N 438 
VAL CG1   HG12   sing N N 439 
VAL CG1   HG13   sing N N 440 
VAL CG2   HG21   sing N N 441 
VAL CG2   HG22   sing N N 442 
VAL CG2   HG23   sing N N 443 
VAL OXT   HXT    sing N N 444 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-07-29 
_em_admin.deposition_site    PDBE 
_em_admin.entry_id           9GAQ 
_em_admin.last_update        2025-02-12 
_em_admin.map_release_date   2025-01-15 
_em_admin.title              'CryoEM structure of influenza A RNP-like particle double-stranded assembled with a 14-mer RNA.' 
# 
loop_
_em_buffer_component.buffer_id 
_em_buffer_component.concentration 
_em_buffer_component.concentration_units 
_em_buffer_component.formula 
_em_buffer_component.id 
_em_buffer_component.name 
1 20  mM ?    1 HEPES                   
1 150 mM NaCl 2 NaCl                    
1 5   mM ?    3 beta-mercaptoethanol    
1 2   mM ?    4 methyl-PEG8-NHS         
1 4   uM ?    5 
;RNA (5'P-(UC)6-FAM3')
;
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_molwt.entity_assembly_id   1 
_em_entity_assembly_molwt.experimental_flag    NO 
_em_entity_assembly_molwt.id                   1 
_em_entity_assembly_molwt.units                ? 
_em_entity_assembly_molwt.value                ? 
# 
loop_
_em_entity_assembly_naturalsource.cell 
_em_entity_assembly_naturalsource.cellular_location 
_em_entity_assembly_naturalsource.entity_assembly_id 
_em_entity_assembly_naturalsource.id 
_em_entity_assembly_naturalsource.ncbi_tax_id 
_em_entity_assembly_naturalsource.organism 
_em_entity_assembly_naturalsource.organelle 
_em_entity_assembly_naturalsource.organ 
_em_entity_assembly_naturalsource.strain 
_em_entity_assembly_naturalsource.tissue 
_em_entity_assembly_naturalsource.details 
? ? 2 2 32630 'synthetic construct' ? ? ? ? ? 
? ? 3 3 11320 'Influenza A virus'   ? ? ? ? ? 
# 
loop_
_em_entity_assembly_recombinant.cell 
_em_entity_assembly_recombinant.entity_assembly_id 
_em_entity_assembly_recombinant.id 
_em_entity_assembly_recombinant.ncbi_tax_id 
_em_entity_assembly_recombinant.organism 
_em_entity_assembly_recombinant.plasmid 
_em_entity_assembly_recombinant.strain 
? 2 2 32630  'synthetic construct'        ? ? 
? 3 3 469008 'Escherichia coli BL21(DE3)' ? ? 
# 
_em_helical_entity.id                             1 
_em_helical_entity.image_processing_id            1 
_em_helical_entity.details                        ? 
_em_helical_entity.axial_symmetry                 C2 
_em_helical_entity.angular_rotation_per_subunit   57.27 
_em_helical_entity.axial_rise_per_subunit         24.55 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         40 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       COUNTING 
_em_image_recording.film_or_detector_model              'GATAN K2 SUMMIT (4k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'            ? 1  1 ? ? ?        ?            
'MODEL REFINEMENT'              ? 2  ? ? ? PHENIX   1.20.1_4487: 
'IMAGE ACQUISITION'             ? 3  ? ? 1 SerialEM ?            
MASKING                         ? 4  ? ? ? ?        ?            
'CTF CORRECTION'                ? 5  1 ? ? ?        ?            
'LAYERLINE INDEXING'            ? 6  ? ? ? ?        ?            
'DIFFRACTION INDEXING'          ? 7  ? ? ? ?        ?            
'MODEL FITTING'                 ? 8  ? ? ? ?        ?            
OTHER                           ? 9  ? ? ? ?        ?            
'INITIAL EULER ASSIGNMENT'      ? 10 1 ? ? ?        ?            
'FINAL EULER ASSIGNMENT'        ? 11 1 ? ? ?        ?            
CLASSIFICATION                  ? 12 1 ? ? ?        ?            
RECONSTRUCTION                  ? 13 1 ? ? ?        ?            
'VOLUME SELECTION'              ? 14 1 1 1 ?        ?            
'SERIES ALIGNMENT'              ? 15 1 1 1 ?        ?            
'MOLECULAR REPLACEMENT'         ? 16 1 1 1 ?        ?            
'LATTICE DISTORTION CORRECTION' ? 17 1 1 1 ?        ?            
'SYMMETRY DETERMINATION'        ? 18 1 1 1 ?        ?            
'CRYSTALLOGRAPHY MERGING'       ? 19 1 1 1 ?        ?            
# 
_em_specimen.concentration           0.23 
_em_specimen.details                 
;20 mM HEPES
150 mM NaCl
5 mM betamercaptoethanol
Incubation overnight with 0.004 uM RNA.
Prior freezing, the sample was incubated with 2 mM methyl PEG8 N hydroxysuccinimide ester reagent.
;
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Agence Nationale de la Recherche (ANR)'                          France ANR-23-CE11-01      1 
'Grenoble Alliance for Integrated Structural Cell Biology (GRAL)' France ANR-17-EURE-0003    2 
'Grenoble Instruct-ERIC Center (ISBG)'                            France ANR-10-INSB-0005-02 3 
# 
_atom_sites.entry_id                    9GAQ 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
P 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM 1    P P     . C   A 1 2   ? 207.426 249.851 222.560 1.00 73.46  ? 8   C   C P     1 
ATOM 2    O OP1   . C   A 1 2   ? 206.944 248.944 223.675 1.00 73.46  ? 8   C   C OP1   1 
ATOM 3    O OP2   . C   A 1 2   ? 208.805 249.479 222.050 1.00 73.46  ? 8   C   C OP2   1 
ATOM 4    O "O5'" . C   A 1 2   ? 206.421 249.621 221.318 1.00 73.46  ? 8   C   C "O5'" 1 
ATOM 5    C "C5'" . C   A 1 2   ? 206.193 250.720 220.400 1.00 73.46  ? 8   C   C "C5'" 1 
ATOM 6    C "C4'" . C   A 1 2   ? 206.270 250.216 218.980 1.00 73.46  ? 8   C   C "C4'" 1 
ATOM 7    O "O4'" . C   A 1 2   ? 207.598 249.696 218.713 1.00 73.46  ? 8   C   C "O4'" 1 
ATOM 8    C "C3'" . C   A 1 2   ? 205.338 249.050 218.632 1.00 73.46  ? 8   C   C "C3'" 1 
ATOM 9    O "O3'" . C   A 1 2   ? 204.032 249.508 218.303 1.00 73.46  ? 8   C   C "O3'" 1 
ATOM 10   C "C2'" . C   A 1 2   ? 206.049 248.440 217.422 1.00 73.46  ? 8   C   C "C2'" 1 
ATOM 11   O "O2'" . C   A 1 2   ? 205.803 249.154 216.229 1.00 73.46  ? 8   C   C "O2'" 1 
ATOM 12   C "C1'" . C   A 1 2   ? 207.520 248.603 217.821 1.00 73.46  ? 8   C   C "C1'" 1 
ATOM 13   N N1    . C   A 1 2   ? 208.080 247.400 218.494 1.00 73.46  ? 8   C   C N1    1 
ATOM 14   C C2    . C   A 1 2   ? 208.170 246.204 217.775 1.00 73.46  ? 8   C   C C2    1 
ATOM 15   O O2    . C   A 1 2   ? 207.780 246.179 216.598 1.00 73.46  ? 8   C   C O2    1 
ATOM 16   N N3    . C   A 1 2   ? 208.683 245.108 218.386 1.00 73.46  ? 8   C   C N3    1 
ATOM 17   C C4    . C   A 1 2   ? 209.097 245.170 219.657 1.00 73.46  ? 8   C   C C4    1 
ATOM 18   N N4    . C   A 1 2   ? 209.590 244.068 220.202 1.00 73.46  ? 8   C   C N4    1 
ATOM 19   C C5    . C   A 1 2   ? 209.019 246.379 220.399 1.00 73.46  ? 8   C   C C5    1 
ATOM 20   C C6    . C   A 1 2   ? 208.506 247.457 219.788 1.00 73.46  ? 8   C   C C6    1 
ATOM 21   P P     . U   A 1 3   ? 202.970 248.887 219.336 1.00 76.29  ? 9   U   C P     1 
ATOM 22   O OP1   . U   A 1 3   ? 203.207 249.420 220.738 1.00 76.29  ? 9   U   C OP1   1 
ATOM 23   O OP2   . U   A 1 3   ? 202.907 247.372 219.240 1.00 76.29  ? 9   U   C OP2   1 
ATOM 24   O "O5'" . U   A 1 3   ? 201.551 249.462 218.825 1.00 76.29  ? 9   U   C "O5'" 1 
ATOM 25   C "C5'" . U   A 1 3   ? 201.072 249.049 217.520 1.00 76.29  ? 9   U   C "C5'" 1 
ATOM 26   C "C4'" . U   A 1 3   ? 200.198 250.126 216.923 1.00 76.29  ? 9   U   C "C4'" 1 
ATOM 27   O "O4'" . U   A 1 3   ? 199.493 250.834 217.969 1.00 76.29  ? 9   U   C "O4'" 1 
ATOM 28   C "C3'" . U   A 1 3   ? 200.914 251.241 216.141 1.00 76.29  ? 9   U   C "C3'" 1 
ATOM 29   O "O3'" . U   A 1 3   ? 200.879 251.033 214.733 1.00 76.29  ? 9   U   C "O3'" 1 
ATOM 30   C "C2'" . U   A 1 3   ? 200.127 252.519 216.482 1.00 76.29  ? 9   U   C "C2'" 1 
ATOM 31   O "O2'" . U   A 1 3   ? 199.557 253.138 215.347 1.00 76.29  ? 9   U   C "O2'" 1 
ATOM 32   C "C1'" . U   A 1 3   ? 198.996 252.008 217.374 1.00 76.29  ? 9   U   C "C1'" 1 
ATOM 33   N N1    . U   A 1 3   ? 198.596 252.993 218.401 1.00 76.29  ? 9   U   C N1    1 
ATOM 34   C C2    . U   A 1 3   ? 197.938 252.535 219.529 1.00 76.29  ? 9   U   C C2    1 
ATOM 35   O O2    . U   A 1 3   ? 197.693 251.356 219.732 1.00 76.29  ? 9   U   C O2    1 
ATOM 36   N N3    . U   A 1 3   ? 197.586 253.512 220.425 1.00 76.29  ? 9   U   C N3    1 
ATOM 37   C C4    . U   A 1 3   ? 197.812 254.868 220.310 1.00 76.29  ? 9   U   C C4    1 
ATOM 38   O O4    . U   A 1 3   ? 197.417 255.623 221.197 1.00 76.29  ? 9   U   C O4    1 
ATOM 39   C C5    . U   A 1 3   ? 198.484 255.266 219.108 1.00 76.29  ? 9   U   C C5    1 
ATOM 40   C C6    . U   A 1 3   ? 198.842 254.332 218.215 1.00 76.29  ? 9   U   C C6    1 
ATOM 41   P P     . C   A 1 4   ? 202.034 250.101 214.114 1.00 76.88  ? 10  C   C P     1 
ATOM 42   O OP1   . C   A 1 4   ? 203.059 249.607 215.122 1.00 78.59  ? 10  C   C OP1   1 
ATOM 43   O OP2   . C   A 1 4   ? 202.640 250.750 212.885 1.00 75.20  ? 10  C   C OP2   1 
ATOM 44   O "O5'" . C   A 1 4   ? 201.194 248.821 213.609 1.00 78.76  ? 10  C   C "O5'" 1 
ATOM 45   C "C5'" . C   A 1 4   ? 200.057 249.041 212.739 1.00 77.93  ? 10  C   C "C5'" 1 
ATOM 46   C "C4'" . C   A 1 4   ? 198.784 248.925 213.539 1.00 78.66  ? 10  C   C "C4'" 1 
ATOM 47   O "O4'" . C   A 1 4   ? 198.549 250.153 214.272 1.00 79.49  ? 10  C   C "O4'" 1 
ATOM 48   C "C3'" . C   A 1 4   ? 197.502 248.724 212.727 1.00 78.23  ? 10  C   C "C3'" 1 
ATOM 49   O "O3'" . C   A 1 4   ? 197.345 247.347 212.418 1.00 77.17  ? 10  C   C "O3'" 1 
ATOM 50   C "C2'" . C   A 1 4   ? 196.437 249.227 213.706 1.00 79.34  ? 10  C   C "C2'" 1 
ATOM 51   O "O2'" . C   A 1 4   ? 196.110 248.280 214.701 1.00 79.34  ? 10  C   C "O2'" 1 
ATOM 52   C "C1'" . C   A 1 4   ? 197.163 250.414 214.351 1.00 78.22  ? 10  C   C "C1'" 1 
ATOM 53   N N1    . C   A 1 4   ? 196.811 251.712 213.702 1.00 20.00  ? 10  C   C N1    1 
ATOM 54   C C2    . C   A 1 4   ? 197.761 252.509 213.046 1.00 20.00  ? 10  C   C C2    1 
ATOM 55   O O2    . C   A 1 4   ? 198.947 252.148 212.989 1.00 20.00  ? 10  C   C O2    1 
ATOM 56   N N3    . C   A 1 4   ? 197.363 253.676 212.481 1.00 20.00  ? 10  C   C N3    1 
ATOM 57   C C4    . C   A 1 4   ? 196.085 254.067 212.542 1.00 20.00  ? 10  C   C C4    1 
ATOM 58   N N4    . C   A 1 4   ? 195.759 255.216 211.970 1.00 20.00  ? 10  C   C N4    1 
ATOM 59   C C5    . C   A 1 4   ? 195.108 253.276 213.198 1.00 20.00  ? 10  C   C C5    1 
ATOM 60   C C6    . C   A 1 4   ? 195.511 252.123 213.750 1.00 20.00  ? 10  C   C C6    1 
ATOM 61   P P     . U   A 1 5   ? 196.477 246.914 211.137 1.00 76.88  ? 11  U   C P     1 
ATOM 62   O OP1   . U   A 1 5   ? 197.107 247.344 209.825 1.00 78.59  ? 11  U   C OP1   1 
ATOM 63   O OP2   . U   A 1 5   ? 195.017 247.296 211.286 1.00 75.20  ? 11  U   C OP2   1 
ATOM 64   O "O5'" . U   A 1 5   ? 196.586 245.302 211.239 1.00 78.76  ? 11  U   C "O5'" 1 
ATOM 65   C "C5'" . U   A 1 5   ? 196.149 244.484 210.125 1.00 77.93  ? 11  U   C "C5'" 1 
ATOM 66   C "C4'" . U   A 1 5   ? 197.341 243.783 209.518 1.00 78.66  ? 11  U   C "C4'" 1 
ATOM 67   O "O4'" . U   A 1 5   ? 198.053 244.714 208.671 1.00 79.49  ? 11  U   C "O4'" 1 
ATOM 68   C "C3'" . U   A 1 5   ? 198.405 243.264 210.498 1.00 78.23  ? 11  U   C "C3'" 1 
ATOM 69   O "O3'" . U   A 1 5   ? 198.235 241.880 210.782 1.00 77.17  ? 11  U   C "O3'" 1 
ATOM 70   C "C2'" . U   A 1 5   ? 199.742 243.458 209.761 1.00 79.34  ? 11  U   C "C2'" 1 
ATOM 71   O "O2'" . U   A 1 5   ? 200.334 242.239 209.366 1.00 79.34  ? 11  U   C "O2'" 1 
ATOM 72   C "C1'" . U   A 1 5   ? 199.366 244.237 208.498 1.00 78.22  ? 11  U   C "C1'" 1 
ATOM 73   N N1    . U   A 1 5   ? 200.259 245.385 208.242 1.00 20.00  ? 11  U   C N1    1 
ATOM 74   C C2    . U   A 1 5   ? 200.283 246.403 209.179 1.00 20.00  ? 11  U   C C2    1 
ATOM 75   O O2    . U   A 1 5   ? 199.608 246.396 210.200 1.00 20.00  ? 11  U   C O2    1 
ATOM 76   N N3    . U   A 1 5   ? 201.133 247.437 208.881 1.00 20.00  ? 11  U   C N3    1 
ATOM 77   C C4    . U   A 1 5   ? 201.942 247.557 207.769 1.00 20.00  ? 11  U   C C4    1 
ATOM 78   O O4    . U   A 1 5   ? 202.652 248.554 207.648 1.00 20.00  ? 11  U   C O4    1 
ATOM 79   C C5    . U   A 1 5   ? 201.861 246.463 206.846 1.00 20.00  ? 11  U   C C5    1 
ATOM 80   C C6    . U   A 1 5   ? 201.040 245.435 207.111 1.00 20.00  ? 11  U   C C6    1 
ATOM 81   P P     . C   A 1 6   ? 197.606 241.481 212.208 1.00 73.99  ? 12  C   C P     1 
ATOM 82   O OP1   . C   A 1 6   ? 196.846 242.606 212.896 1.00 73.99  ? 12  C   C OP1   1 
ATOM 83   O OP2   . C   A 1 6   ? 198.602 240.781 213.114 1.00 73.99  ? 12  C   C OP2   1 
ATOM 84   O "O5'" . C   A 1 6   ? 196.481 240.402 211.773 1.00 73.99  ? 12  C   C "O5'" 1 
ATOM 85   C "C5'" . C   A 1 6   ? 196.850 239.289 210.923 1.00 73.99  ? 12  C   C "C5'" 1 
ATOM 86   C "C4'" . C   A 1 6   ? 197.610 238.273 211.737 1.00 73.99  ? 12  C   C "C4'" 1 
ATOM 87   O "O4'" . C   A 1 6   ? 197.058 236.951 211.530 1.00 73.99  ? 12  C   C "O4'" 1 
ATOM 88   C "C3'" . C   A 1 6   ? 199.082 238.095 211.360 1.00 73.99  ? 12  C   C "C3'" 1 
ATOM 89   O "O3'" . C   A 1 6   ? 199.787 237.481 212.429 1.00 73.99  ? 12  C   C "O3'" 1 
ATOM 90   C "C2'" . C   A 1 6   ? 198.962 237.193 210.128 1.00 73.99  ? 12  C   C "C2'" 1 
ATOM 91   O "O2'" . C   A 1 6   ? 200.123 236.418 209.923 1.00 73.99  ? 12  C   C "O2'" 1 
ATOM 92   C "C1'" . C   A 1 6   ? 197.778 236.295 210.508 1.00 73.99  ? 12  C   C "C1'" 1 
ATOM 93   N N1    . C   A 1 6   ? 196.845 236.070 209.374 1.00 73.99  ? 12  C   C N1    1 
ATOM 94   C C2    . C   A 1 6   ? 195.707 235.292 209.599 1.00 73.99  ? 12  C   C C2    1 
ATOM 95   O O2    . C   A 1 6   ? 195.532 234.798 210.723 1.00 73.99  ? 12  C   C O2    1 
ATOM 96   N N3    . C   A 1 6   ? 194.836 235.095 208.581 1.00 73.99  ? 12  C   C N3    1 
ATOM 97   C C4    . C   A 1 6   ? 195.058 235.649 207.383 1.00 73.99  ? 12  C   C C4    1 
ATOM 98   N N4    . C   A 1 6   ? 194.177 235.413 206.423 1.00 73.99  ? 12  C   C N4    1 
ATOM 99   C C5    . C   A 1 6   ? 196.210 236.446 207.139 1.00 73.99  ? 12  C   C C5    1 
ATOM 100  C C6    . C   A 1 6   ? 197.065 236.636 208.154 1.00 73.99  ? 12  C   C C6    1 
ATOM 101  P P     . U   A 1 7   ? 201.195 238.230 212.608 1.00 73.64  ? 13  U   C P     1 
ATOM 102  O OP1   . U   A 1 7   ? 201.415 238.658 214.046 1.00 73.64  ? 13  U   C OP1   1 
ATOM 103  O OP2   . U   A 1 7   ? 201.391 239.331 211.583 1.00 73.64  ? 13  U   C OP2   1 
ATOM 104  O "O5'" . U   A 1 7   ? 202.233 237.045 212.281 1.00 73.64  ? 13  U   C "O5'" 1 
ATOM 105  C "C5'" . U   A 1 7   ? 202.028 235.766 212.926 1.00 73.64  ? 13  U   C "C5'" 1 
ATOM 106  C "C4'" . U   A 1 7   ? 202.168 234.657 211.914 1.00 73.64  ? 13  U   C "C4'" 1 
ATOM 107  O "O4'" . U   A 1 7   ? 200.874 234.295 211.383 1.00 73.64  ? 13  U   C "O4'" 1 
ATOM 108  C "C3'" . U   A 1 7   ? 202.978 234.972 210.650 1.00 73.64  ? 13  U   C "C3'" 1 
ATOM 109  O "O3'" . U   A 1 7   ? 204.364 234.739 210.868 1.00 73.64  ? 13  U   C "O3'" 1 
ATOM 110  C "C2'" . U   A 1 7   ? 202.386 234.017 209.597 1.00 73.64  ? 13  U   C "C2'" 1 
ATOM 111  O "O2'" . U   A 1 7   ? 203.240 232.936 209.289 1.00 73.64  ? 13  U   C "O2'" 1 
ATOM 112  C "C1'" . U   A 1 7   ? 201.127 233.465 210.274 1.00 73.64  ? 13  U   C "C1'" 1 
ATOM 113  N N1    . U   A 1 7   ? 199.953 233.451 209.378 1.00 73.64  ? 13  U   C N1    1 
ATOM 114  C C2    . U   A 1 7   ? 198.822 232.794 209.824 1.00 73.64  ? 13  U   C C2    1 
ATOM 115  O O2    . U   A 1 7   ? 198.753 232.256 210.920 1.00 73.64  ? 13  U   C O2    1 
ATOM 116  N N3    . U   A 1 7   ? 197.773 232.788 208.941 1.00 73.64  ? 13  U   C N3    1 
ATOM 117  C C4    . U   A 1 7   ? 197.743 233.353 207.682 1.00 73.64  ? 13  U   C C4    1 
ATOM 118  O O4    . U   A 1 7   ? 196.718 233.269 207.006 1.00 73.64  ? 13  U   C O4    1 
ATOM 119  C C5    . U   A 1 7   ? 198.956 234.009 207.290 1.00 73.64  ? 13  U   C C5    1 
ATOM 120  C C6    . U   A 1 7   ? 199.999 234.029 208.132 1.00 73.64  ? 13  U   C C6    1 
ATOM 121  O OP3   . U   B 1 1   ? 187.868 213.673 219.737 1.00 20.00  ? 1   U   D OP3   1 
ATOM 122  P P     . U   B 1 1   ? 186.994 214.786 220.283 1.00 20.00  ? 1   U   D P     1 
ATOM 123  O OP1   . U   B 1 1   ? 185.611 214.811 219.658 1.00 20.00  ? 1   U   D OP1   1 
ATOM 124  O OP2   . U   B 1 1   ? 187.676 216.139 220.259 1.00 20.00  ? 1   U   D OP2   1 
ATOM 125  O "O5'" . U   B 1 1   ? 186.782 214.445 221.845 1.00 20.00  ? 1   U   D "O5'" 1 
ATOM 126  C "C5'" . U   B 1 1   ? 185.943 213.323 222.203 1.00 20.00  ? 1   U   D "C5'" 1 
ATOM 127  C "C4'" . U   B 1 1   ? 184.547 213.819 222.478 1.00 20.00  ? 1   U   D "C4'" 1 
ATOM 128  O "O4'" . U   B 1 1   ? 183.642 213.268 221.488 1.00 20.00  ? 1   U   D "O4'" 1 
ATOM 129  C "C3'" . U   B 1 1   ? 183.964 213.417 223.839 1.00 20.00  ? 1   U   D "C3'" 1 
ATOM 130  O "O3'" . U   B 1 1   ? 183.050 214.383 224.343 1.00 20.00  ? 1   U   D "O3'" 1 
ATOM 131  C "C2'" . U   B 1 1   ? 183.266 212.094 223.513 1.00 20.00  ? 1   U   D "C2'" 1 
ATOM 132  O "O2'" . U   B 1 1   ? 182.153 211.838 224.341 1.00 20.00  ? 1   U   D "O2'" 1 
ATOM 133  C "C1'" . U   B 1 1   ? 182.766 212.340 222.089 1.00 20.00  ? 1   U   D "C1'" 1 
ATOM 134  N N1    . U   B 1 1   ? 182.751 211.102 221.278 1.00 20.00  ? 1   U   D N1    1 
ATOM 135  C C2    . U   B 1 1   ? 181.530 210.620 220.829 1.00 20.00  ? 1   U   D C2    1 
ATOM 136  O O2    . U   B 1 1   ? 180.457 211.165 221.052 1.00 20.00  ? 1   U   D O2    1 
ATOM 137  N N3    . U   B 1 1   ? 181.606 209.464 220.096 1.00 20.00  ? 1   U   D N3    1 
ATOM 138  C C4    . U   B 1 1   ? 182.743 208.751 219.773 1.00 20.00  ? 1   U   D C4    1 
ATOM 139  O O4    . U   B 1 1   ? 182.641 207.723 219.105 1.00 20.00  ? 1   U   D O4    1 
ATOM 140  C C5    . U   B 1 1   ? 183.962 209.309 220.276 1.00 20.00  ? 1   U   D C5    1 
ATOM 141  C C6    . U   B 1 1   ? 183.922 210.440 220.995 1.00 20.00  ? 1   U   D C6    1 
ATOM 142  P P     . C   B 1 2   ? 183.547 215.530 225.379 1.00 82.97  ? 2   C   D P     1 
ATOM 143  O OP1   . C   B 1 2   ? 182.451 216.524 225.253 1.00 82.97  ? 2   C   D OP1   1 
ATOM 144  O OP2   . C   B 1 2   ? 184.953 215.970 225.205 1.00 82.97  ? 2   C   D OP2   1 
ATOM 145  O "O5'" . C   B 1 2   ? 183.413 214.827 226.802 1.00 82.97  ? 2   C   D "O5'" 1 
ATOM 146  C "C5'" . C   B 1 2   ? 184.135 213.643 227.104 1.00 82.97  ? 2   C   D "C5'" 1 
ATOM 147  C "C4'" . C   B 1 2   ? 184.808 213.743 228.447 1.00 82.97  ? 2   C   D "C4'" 1 
ATOM 148  O "O4'" . C   B 1 2   ? 186.143 213.178 228.371 1.00 82.97  ? 2   C   D "O4'" 1 
ATOM 149  C "C3'" . C   B 1 2   ? 185.036 215.155 228.962 1.00 82.97  ? 2   C   D "C3'" 1 
ATOM 150  O "O3'" . C   B 1 2   ? 183.881 215.709 229.567 1.00 82.97  ? 2   C   D "O3'" 1 
ATOM 151  C "C2'" . C   B 1 2   ? 186.202 214.980 229.924 1.00 82.97  ? 2   C   D "C2'" 1 
ATOM 152  O "O2'" . C   B 1 2   ? 185.749 214.481 231.174 1.00 82.97  ? 2   C   D "O2'" 1 
ATOM 153  C "C1'" . C   B 1 2   ? 187.012 213.884 229.231 1.00 82.97  ? 2   C   D "C1'" 1 
ATOM 154  N N1    . C   B 1 2   ? 188.172 214.415 228.469 1.00 82.97  ? 2   C   D N1    1 
ATOM 155  C C2    . C   B 1 2   ? 188.117 214.769 227.109 1.00 82.97  ? 2   C   D C2    1 
ATOM 156  O O2    . C   B 1 2   ? 187.073 214.653 226.455 1.00 82.97  ? 2   C   D O2    1 
ATOM 157  N N3    . C   B 1 2   ? 189.231 215.242 226.503 1.00 82.97  ? 2   C   D N3    1 
ATOM 158  C C4    . C   B 1 2   ? 190.368 215.377 227.182 1.00 82.97  ? 2   C   D C4    1 
ATOM 159  N N4    . C   B 1 2   ? 191.434 215.850 226.533 1.00 82.97  ? 2   C   D N4    1 
ATOM 160  C C5    . C   B 1 2   ? 190.459 215.031 228.558 1.00 82.97  ? 2   C   D C5    1 
ATOM 161  C C6    . C   B 1 2   ? 189.352 214.563 229.146 1.00 82.97  ? 2   C   D C6    1 
ATOM 162  P P     . U   B 1 3   ? 183.633 217.296 229.539 1.00 82.14  ? 3   U   D P     1 
ATOM 163  O OP1   . U   B 1 3   ? 182.199 217.543 229.833 1.00 82.14  ? 3   U   D OP1   1 
ATOM 164  O OP2   . U   B 1 3   ? 184.231 217.833 228.291 1.00 82.14  ? 3   U   D OP2   1 
ATOM 165  O "O5'" . U   B 1 3   ? 184.487 217.839 230.768 1.00 82.14  ? 3   U   D "O5'" 1 
ATOM 166  C "C5'" . U   B 1 3   ? 184.266 217.346 232.081 1.00 82.14  ? 3   U   D "C5'" 1 
ATOM 167  C "C4'" . U   B 1 3   ? 185.468 217.567 232.963 1.00 82.14  ? 3   U   D "C4'" 1 
ATOM 168  O "O4'" . U   B 1 3   ? 186.623 216.904 232.378 1.00 82.14  ? 3   U   D "O4'" 1 
ATOM 169  C "C3'" . U   B 1 3   ? 185.925 219.008 233.119 1.00 82.14  ? 3   U   D "C3'" 1 
ATOM 170  O "O3'" . U   B 1 3   ? 185.115 219.812 233.979 1.00 82.14  ? 3   U   D "O3'" 1 
ATOM 171  C "C2'" . U   B 1 3   ? 187.395 218.846 233.500 1.00 82.14  ? 3   U   D "C2'" 1 
ATOM 172  O "O2'" . U   B 1 3   ? 187.554 218.425 234.846 1.00 82.14  ? 3   U   D "O2'" 1 
ATOM 173  C "C1'" . U   B 1 3   ? 187.790 217.671 232.610 1.00 82.14  ? 3   U   D "C1'" 1 
ATOM 174  N N1    . U   B 1 3   ? 188.339 218.123 231.310 1.00 82.14  ? 3   U   D N1    1 
ATOM 175  C C2    . U   B 1 3   ? 189.673 218.479 231.277 1.00 82.14  ? 3   U   D C2    1 
ATOM 176  O O2    . U   B 1 3   ? 190.394 218.430 232.259 1.00 82.14  ? 3   U   D O2    1 
ATOM 177  N N3    . U   B 1 3   ? 190.137 218.892 230.053 1.00 82.14  ? 3   U   D N3    1 
ATOM 178  C C4    . U   B 1 3   ? 189.417 218.986 228.880 1.00 82.14  ? 3   U   D C4    1 
ATOM 179  O O4    . U   B 1 3   ? 189.977 219.376 227.855 1.00 82.14  ? 3   U   D O4    1 
ATOM 180  C C5    . U   B 1 3   ? 188.045 218.603 228.993 1.00 82.14  ? 3   U   D C5    1 
ATOM 181  C C6    . U   B 1 3   ? 187.567 218.196 230.174 1.00 82.14  ? 3   U   D C6    1 
ATOM 182  P P     . C   B 1 4   ? 185.127 219.679 235.583 1.00 80.09  ? 4   C   D P     1 
ATOM 183  O OP1   . C   B 1 4   ? 185.312 218.259 235.971 1.00 80.09  ? 4   C   D OP1   1 
ATOM 184  O OP2   . C   B 1 4   ? 183.952 220.423 236.100 1.00 80.09  ? 4   C   D OP2   1 
ATOM 185  O "O5'" . C   B 1 4   ? 186.431 220.479 236.027 1.00 80.09  ? 4   C   D "O5'" 1 
ATOM 186  C "C5'" . C   B 1 4   ? 186.957 220.330 237.336 1.00 80.09  ? 4   C   D "C5'" 1 
ATOM 187  C "C4'" . C   B 1 4   ? 188.213 221.140 237.537 1.00 80.09  ? 4   C   D "C4'" 1 
ATOM 188  O "O4'" . C   B 1 4   ? 189.243 220.719 236.606 1.00 80.09  ? 4   C   D "O4'" 1 
ATOM 189  C "C3'" . C   B 1 4   ? 188.101 222.634 237.294 1.00 80.09  ? 4   C   D "C3'" 1 
ATOM 190  O "O3'" . C   B 1 4   ? 187.485 223.325 238.366 1.00 80.09  ? 4   C   D "O3'" 1 
ATOM 191  C "C2'" . C   B 1 4   ? 189.553 223.034 237.058 1.00 80.09  ? 4   C   D "C2'" 1 
ATOM 192  O "O2'" . C   B 1 4   ? 190.253 223.129 238.290 1.00 80.09  ? 4   C   D "O2'" 1 
ATOM 193  C "C1'" . C   B 1 4   ? 190.084 221.814 236.300 1.00 80.09  ? 4   C   D "C1'" 1 
ATOM 194  N N1    . C   B 1 4   ? 190.098 222.031 234.835 1.00 80.09  ? 4   C   D N1    1 
ATOM 195  C C2    . C   B 1 4   ? 191.266 222.530 234.253 1.00 80.09  ? 4   C   D C2    1 
ATOM 196  O O2    . C   B 1 4   ? 192.242 222.761 234.981 1.00 80.09  ? 4   C   D O2    1 
ATOM 197  N N3    . C   B 1 4   ? 191.307 222.743 232.919 1.00 80.09  ? 4   C   D N3    1 
ATOM 198  C C4    . C   B 1 4   ? 190.236 222.481 232.170 1.00 80.09  ? 4   C   D C4    1 
ATOM 199  N N4    . C   B 1 4   ? 190.318 222.706 230.857 1.00 80.09  ? 4   C   D N4    1 
ATOM 200  C C5    . C   B 1 4   ? 189.030 221.977 232.734 1.00 80.09  ? 4   C   D C5    1 
ATOM 201  C C6    . C   B 1 4   ? 189.007 221.773 234.057 1.00 80.09  ? 4   C   D C6    1 
ATOM 202  P P     . U   B 1 5   ? 186.708 224.705 238.096 1.00 77.31  ? 5   U   D P     1 
ATOM 203  O OP1   . U   B 1 5   ? 185.800 224.958 239.243 1.00 77.31  ? 5   U   D OP1   1 
ATOM 204  O OP2   . U   B 1 5   ? 186.151 224.662 236.721 1.00 77.31  ? 5   U   D OP2   1 
ATOM 205  O "O5'" . U   B 1 5   ? 187.863 225.800 238.133 1.00 77.31  ? 5   U   D "O5'" 1 
ATOM 206  C "C5'" . U   B 1 5   ? 188.789 225.831 239.207 1.00 77.31  ? 5   U   D "C5'" 1 
ATOM 207  C "C4'" . U   B 1 5   ? 190.112 226.416 238.784 1.00 77.31  ? 5   U   D "C4'" 1 
ATOM 208  O "O4'" . U   B 1 5   ? 189.935 227.818 238.462 1.00 77.31  ? 5   U   D "O4'" 1 
ATOM 209  C "C3'" . U   B 1 5   ? 191.202 226.404 239.845 1.00 77.31  ? 5   U   D "C3'" 1 
ATOM 210  O "O3'" . U   B 1 5   ? 191.896 225.169 239.892 1.00 77.31  ? 5   U   D "O3'" 1 
ATOM 211  C "C2'" . U   B 1 5   ? 192.085 227.577 239.443 1.00 77.31  ? 5   U   D "C2'" 1 
ATOM 212  O "O2'" . U   B 1 5   ? 192.965 227.205 238.393 1.00 77.31  ? 5   U   D "O2'" 1 
ATOM 213  C "C1'" . U   B 1 5   ? 191.057 228.560 238.884 1.00 77.31  ? 5   U   D "C1'" 1 
ATOM 214  N N1    . U   B 1 5   ? 190.603 229.555 239.882 1.00 77.31  ? 5   U   D N1    1 
ATOM 215  C C2    . U   B 1 5   ? 191.392 230.665 240.104 1.00 77.31  ? 5   U   D C2    1 
ATOM 216  O O2    . U   B 1 5   ? 192.451 230.850 239.533 1.00 77.31  ? 5   U   D O2    1 
ATOM 217  N N3    . U   B 1 5   ? 190.896 231.552 241.027 1.00 77.31  ? 5   U   D N3    1 
ATOM 218  C C4    . U   B 1 5   ? 189.714 231.448 241.730 1.00 77.31  ? 5   U   D C4    1 
ATOM 219  O O4    . U   B 1 5   ? 189.403 232.331 242.530 1.00 77.31  ? 5   U   D O4    1 
ATOM 220  C C5    . U   B 1 5   ? 188.950 230.276 241.439 1.00 77.31  ? 5   U   D C5    1 
ATOM 221  C C6    . U   B 1 5   ? 189.408 229.396 240.544 1.00 77.31  ? 5   U   D C6    1 
ATOM 222  P P     . C   B 1 6   ? 192.252 224.486 241.301 1.00 76.56  ? 6   C   D P     1 
ATOM 223  O OP1   . C   B 1 6   ? 192.717 223.103 241.032 1.00 76.56  ? 6   C   D OP1   1 
ATOM 224  O OP2   . C   B 1 6   ? 191.111 224.710 242.224 1.00 76.56  ? 6   C   D OP2   1 
ATOM 225  O "O5'" . C   B 1 6   ? 193.492 225.331 241.835 1.00 76.56  ? 6   C   D "O5'" 1 
ATOM 226  C "C5'" . C   B 1 6   ? 194.656 225.500 241.040 1.00 76.56  ? 6   C   D "C5'" 1 
ATOM 227  C "C4'" . C   B 1 6   ? 195.436 226.719 241.461 1.00 76.56  ? 6   C   D "C4'" 1 
ATOM 228  O "O4'" . C   B 1 6   ? 194.600 227.897 241.341 1.00 76.56  ? 6   C   D "O4'" 1 
ATOM 229  C "C3'" . C   B 1 6   ? 195.905 226.742 242.907 1.00 76.56  ? 6   C   D "C3'" 1 
ATOM 230  O "O3'" . C   B 1 6   ? 197.094 226.000 243.115 1.00 76.56  ? 6   C   D "O3'" 1 
ATOM 231  C "C2'" . C   B 1 6   ? 196.058 228.232 243.185 1.00 76.56  ? 6   C   D "C2'" 1 
ATOM 232  O "O2'" . C   B 1 6   ? 197.275 228.720 242.641 1.00 76.56  ? 6   C   D "O2'" 1 
ATOM 233  C "C1'" . C   B 1 6   ? 194.900 228.812 242.373 1.00 76.56  ? 6   C   D "C1'" 1 
ATOM 234  N N1    . C   B 1 6   ? 193.683 229.012 243.193 1.00 76.56  ? 6   C   D N1    1 
ATOM 235  C C2    . C   B 1 6   ? 193.550 230.201 243.913 1.00 76.56  ? 6   C   D C2    1 
ATOM 236  O O2    . C   B 1 6   ? 194.454 231.046 243.845 1.00 76.56  ? 6   C   D O2    1 
ATOM 237  N N3    . C   B 1 6   ? 192.441 230.398 244.663 1.00 76.56  ? 6   C   D N3    1 
ATOM 238  C C4    . C   B 1 6   ? 191.491 229.464 244.710 1.00 76.56  ? 6   C   D C4    1 
ATOM 239  N N4    . C   B 1 6   ? 190.416 229.702 245.463 1.00 76.56  ? 6   C   D N4    1 
ATOM 240  C C5    . C   B 1 6   ? 191.599 228.243 243.986 1.00 76.56  ? 6   C   D C5    1 
ATOM 241  C C6    . C   B 1 6   ? 192.700 228.063 243.247 1.00 76.56  ? 6   C   D C6    1 
ATOM 242  P P     . U   B 1 7   ? 197.357 225.270 244.522 1.00 75.29  ? 7   U   D P     1 
ATOM 243  O OP1   . U   B 1 7   ? 196.185 224.409 244.820 1.00 75.29  ? 7   U   D OP1   1 
ATOM 244  O OP2   . U   B 1 7   ? 197.780 226.300 245.504 1.00 75.29  ? 7   U   D OP2   1 
ATOM 245  O "O5'" . U   B 1 7   ? 198.604 224.323 244.238 1.00 75.29  ? 7   U   D "O5'" 1 
ATOM 246  C "C5'" . U   B 1 7   ? 198.594 223.410 243.146 1.00 75.29  ? 7   U   D "C5'" 1 
ATOM 247  C "C4'" . U   B 1 7   ? 199.359 222.146 243.458 1.00 75.29  ? 7   U   D "C4'" 1 
ATOM 248  O "O4'" . U   B 1 7   ? 200.787 222.414 243.403 1.00 75.29  ? 7   U   D "O4'" 1 
ATOM 249  C "C3'" . U   B 1 7   ? 199.088 221.532 244.832 1.00 75.29  ? 7   U   D "C3'" 1 
ATOM 250  O "O3'" . U   B 1 7   ? 199.103 220.110 244.730 1.00 75.29  ? 7   U   D "O3'" 1 
ATOM 251  C "C2'" . U   B 1 7   ? 200.285 221.998 245.656 1.00 75.29  ? 7   U   D "C2'" 1 
ATOM 252  O "O2'" . U   B 1 7   ? 200.602 221.164 246.751 1.00 75.29  ? 7   U   D "O2'" 1 
ATOM 253  C "C1'" . U   B 1 7   ? 201.396 222.002 244.611 1.00 75.29  ? 7   U   D "C1'" 1 
ATOM 254  N N1    . U   B 1 7   ? 202.512 222.914 244.914 1.00 75.29  ? 7   U   D N1    1 
ATOM 255  C C2    . U   B 1 7   ? 202.329 224.285 244.831 1.00 75.29  ? 7   U   D C2    1 
ATOM 256  O O2    . U   B 1 7   ? 201.279 224.816 244.516 1.00 75.29  ? 7   U   D O2    1 
ATOM 257  N N3    . U   B 1 7   ? 203.435 225.038 245.135 1.00 75.29  ? 7   U   D N3    1 
ATOM 258  C C4    . U   B 1 7   ? 204.680 224.579 245.506 1.00 75.29  ? 7   U   D C4    1 
ATOM 259  O O4    . U   B 1 7   ? 205.576 225.388 245.748 1.00 75.29  ? 7   U   D O4    1 
ATOM 260  C C5    . U   B 1 7   ? 204.792 223.156 245.569 1.00 75.29  ? 7   U   D C5    1 
ATOM 261  C C6    . U   B 1 7   ? 203.732 222.396 245.278 1.00 75.29  ? 7   U   D C6    1 
ATOM 262  N N     . SER C 2 391 ? 201.149 232.498 246.788 1.00 59.02  ? 403 SER B N     1 
ATOM 263  C CA    . SER C 2 391 ? 201.706 233.321 245.721 1.00 59.02  ? 403 SER B CA    1 
ATOM 264  C C     . SER C 2 391 ? 200.612 233.805 244.775 1.00 59.02  ? 403 SER B C     1 
ATOM 265  O O     . SER C 2 391 ? 199.430 233.784 245.118 1.00 59.02  ? 403 SER B O     1 
ATOM 266  C CB    . SER C 2 391 ? 202.769 232.544 244.943 1.00 59.02  ? 403 SER B CB    1 
ATOM 267  O OG    . SER C 2 391 ? 202.176 231.570 244.101 1.00 59.02  ? 403 SER B OG    1 
ATOM 268  N N     . GLY C 2 392 ? 201.012 234.246 243.589 1.00 63.53  ? 404 GLY B N     1 
ATOM 269  C CA    . GLY C 2 392 ? 200.050 234.705 242.604 1.00 63.53  ? 404 GLY B CA    1 
ATOM 270  C C     . GLY C 2 392 ? 200.751 235.422 241.471 1.00 63.53  ? 404 GLY B C     1 
ATOM 271  O O     . GLY C 2 392 ? 201.983 235.453 241.387 1.00 63.53  ? 404 GLY B O     1 
ATOM 272  N N     . GLN C 2 393 ? 199.933 235.997 240.592 1.00 69.84  ? 405 GLN B N     1 
ATOM 273  C CA    . GLN C 2 393 ? 200.414 236.832 239.503 1.00 69.84  ? 405 GLN B CA    1 
ATOM 274  C C     . GLN C 2 393 ? 201.233 238.000 240.051 1.00 69.84  ? 405 GLN B C     1 
ATOM 275  O O     . GLN C 2 393 ? 200.931 238.562 241.107 1.00 69.84  ? 405 GLN B O     1 
ATOM 276  C CB    . GLN C 2 393 ? 199.231 237.341 238.678 1.00 69.84  ? 405 GLN B CB    1 
ATOM 277  C CG    . GLN C 2 393 ? 199.574 238.371 237.622 1.00 69.84  ? 405 GLN B CG    1 
ATOM 278  C CD    . GLN C 2 393 ? 200.472 237.831 236.535 1.00 69.84  ? 405 GLN B CD    1 
ATOM 279  O OE1   . GLN C 2 393 ? 201.192 238.587 235.889 1.00 69.84  ? 405 GLN B OE1   1 
ATOM 280  N NE2   . GLN C 2 393 ? 200.418 236.523 236.308 1.00 69.84  ? 405 GLN B NE2   1 
ATOM 281  N N     . ILE C 2 394 ? 202.291 238.369 239.325 1.00 69.38  ? 406 ILE B N     1 
ATOM 282  C CA    . ILE C 2 394 ? 203.194 239.387 239.849 1.00 69.38  ? 406 ILE B CA    1 
ATOM 283  C C     . ILE C 2 394 ? 203.209 240.662 239.022 1.00 69.38  ? 406 ILE B C     1 
ATOM 284  O O     . ILE C 2 394 ? 202.797 241.719 239.507 1.00 69.38  ? 406 ILE B O     1 
ATOM 285  C CB    . ILE C 2 394 ? 204.636 238.863 239.949 1.00 69.38  ? 406 ILE B CB    1 
ATOM 286  C CG1   . ILE C 2 394 ? 204.741 237.691 240.910 1.00 69.38  ? 406 ILE B CG1   1 
ATOM 287  C CG2   . ILE C 2 394 ? 205.579 239.981 240.373 1.00 69.38  ? 406 ILE B CG2   1 
ATOM 288  C CD1   . ILE C 2 394 ? 206.064 237.016 240.794 1.00 69.38  ? 406 ILE B CD1   1 
ATOM 289  N N     . SER C 2 395 ? 203.717 240.601 237.790 1.00 68.39  ? 407 SER B N     1 
ATOM 290  C CA    . SER C 2 395 ? 204.052 241.885 237.191 1.00 68.39  ? 407 SER B CA    1 
ATOM 291  C C     . SER C 2 395 ? 203.008 242.434 236.230 1.00 68.39  ? 407 SER B C     1 
ATOM 292  O O     . SER C 2 395 ? 202.189 243.274 236.618 1.00 68.39  ? 407 SER B O     1 
ATOM 293  C CB    . SER C 2 395 ? 205.387 241.760 236.456 1.00 68.39  ? 407 SER B CB    1 
ATOM 294  O OG    . SER C 2 395 ? 205.535 240.468 235.892 1.00 68.39  ? 407 SER B OG    1 
ATOM 295  N N     . ILE C 2 396 ? 203.040 241.984 234.969 1.00 64.58  ? 408 ILE B N     1 
ATOM 296  C CA    . ILE C 2 396 ? 202.004 242.418 233.979 1.00 64.58  ? 408 ILE B CA    1 
ATOM 297  C C     . ILE C 2 396 ? 202.315 241.841 232.595 1.00 64.58  ? 408 ILE B C     1 
ATOM 298  O O     . ILE C 2 396 ? 203.485 241.482 232.351 1.00 64.58  ? 408 ILE B O     1 
ATOM 299  C CB    . ILE C 2 396 ? 201.892 243.957 233.909 1.00 64.58  ? 408 ILE B CB    1 
ATOM 300  C CG1   . ILE C 2 396 ? 200.434 244.413 233.820 1.00 64.58  ? 408 ILE B CG1   1 
ATOM 301  C CG2   . ILE C 2 396 ? 202.727 244.516 232.768 1.00 64.58  ? 408 ILE B CG2   1 
ATOM 302  C CD1   . ILE C 2 396 ? 199.476 243.566 234.626 1.00 64.58  ? 408 ILE B CD1   1 
ATOM 303  N N     . GLN C 2 397 ? 201.299 241.753 231.731 1.00 65.39  ? 409 GLN B N     1 
ATOM 304  C CA    . GLN C 2 397 ? 201.523 241.307 230.330 1.00 65.39  ? 409 GLN B CA    1 
ATOM 305  C C     . GLN C 2 397 ? 200.888 242.357 229.416 1.00 65.39  ? 409 GLN B C     1 
ATOM 306  O O     . GLN C 2 397 ? 199.693 242.214 229.090 1.00 65.39  ? 409 GLN B O     1 
ATOM 307  C CB    . GLN C 2 397 ? 200.939 239.914 230.092 1.00 65.39  ? 409 GLN B CB    1 
ATOM 308  C CG    . GLN C 2 397 ? 201.284 239.338 228.726 1.00 65.39  ? 409 GLN B CG    1 
ATOM 309  C CD    . GLN C 2 397 ? 202.604 239.854 228.208 1.00 65.39  ? 409 GLN B CD    1 
ATOM 310  O OE1   . GLN C 2 397 ? 203.672 239.471 228.682 1.00 65.39  ? 409 GLN B OE1   1 
ATOM 311  N NE2   . GLN C 2 397 ? 202.541 240.735 227.224 1.00 65.39  ? 409 GLN B NE2   1 
ATOM 312  N N     . PRO C 2 398 ? 201.629 243.404 228.993 1.00 63.20  ? 410 PRO B N     1 
ATOM 313  C CA    . PRO C 2 398 ? 201.051 244.497 228.200 1.00 63.20  ? 410 PRO B CA    1 
ATOM 314  C C     . PRO C 2 398 ? 200.300 244.021 226.949 1.00 63.20  ? 410 PRO B C     1 
ATOM 315  O O     . PRO C 2 398 ? 200.946 243.569 226.022 1.00 63.20  ? 410 PRO B O     1 
ATOM 316  C CB    . PRO C 2 398 ? 202.274 245.331 227.779 1.00 63.20  ? 410 PRO B CB    1 
ATOM 317  C CG    . PRO C 2 398 ? 203.463 244.427 228.032 1.00 63.20  ? 410 PRO B CG    1 
ATOM 318  C CD    . PRO C 2 398 ? 203.061 243.580 229.220 1.00 63.20  ? 410 PRO B CD    1 
ATOM 319  N N     . THR C 2 399 ? 198.968 244.129 226.955 1.00 61.27  ? 411 THR B N     1 
ATOM 320  C CA    . THR C 2 399 ? 198.198 243.784 225.769 1.00 61.27  ? 411 THR B CA    1 
ATOM 321  C C     . THR C 2 399 ? 197.776 245.003 224.967 1.00 61.27  ? 411 THR B C     1 
ATOM 322  O O     . THR C 2 399 ? 197.897 245.000 223.739 1.00 61.27  ? 411 THR B O     1 
ATOM 323  C CB    . THR C 2 399 ? 196.953 242.970 226.169 1.00 61.27  ? 411 THR B CB    1 
ATOM 324  O OG1   . THR C 2 399 ? 197.317 241.599 226.361 1.00 61.27  ? 411 THR B OG1   1 
ATOM 325  C CG2   . THR C 2 399 ? 195.882 243.043 225.094 1.00 61.27  ? 411 THR B CG2   1 
ATOM 326  N N     . PHE C 2 400 ? 197.312 246.058 225.629 1.00 57.65  ? 412 PHE B N     1 
ATOM 327  C CA    . PHE C 2 400 ? 196.826 247.252 224.958 1.00 57.65  ? 412 PHE B CA    1 
ATOM 328  C C     . PHE C 2 400 ? 197.899 248.334 224.951 1.00 57.65  ? 412 PHE B C     1 
ATOM 329  O O     . PHE C 2 400 ? 198.688 248.460 225.891 1.00 57.65  ? 412 PHE B O     1 
ATOM 330  C CB    . PHE C 2 400 ? 195.559 247.782 225.631 1.00 57.65  ? 412 PHE B CB    1 
ATOM 331  C CG    . PHE C 2 400 ? 194.406 246.821 225.598 1.00 57.65  ? 412 PHE B CG    1 
ATOM 332  C CD1   . PHE C 2 400 ? 194.286 245.828 226.554 1.00 57.65  ? 412 PHE B CD1   1 
ATOM 333  C CD2   . PHE C 2 400 ? 193.449 246.901 224.602 1.00 57.65  ? 412 PHE B CD2   1 
ATOM 334  C CE1   . PHE C 2 400 ? 193.229 244.942 226.525 1.00 57.65  ? 412 PHE B CE1   1 
ATOM 335  C CE2   . PHE C 2 400 ? 192.390 246.017 224.567 1.00 57.65  ? 412 PHE B CE2   1 
ATOM 336  C CZ    . PHE C 2 400 ? 192.281 245.036 225.529 1.00 57.65  ? 412 PHE B CZ    1 
ATOM 337  N N     . SER C 2 401 ? 197.915 249.120 223.874 1.00 58.85  ? 413 SER B N     1 
ATOM 338  C CA    . SER C 2 401 ? 198.907 250.180 223.695 1.00 58.85  ? 413 SER B CA    1 
ATOM 339  C C     . SER C 2 401 ? 198.423 251.435 224.414 1.00 58.85  ? 413 SER B C     1 
ATOM 340  O O     . SER C 2 401 ? 197.979 252.413 223.809 1.00 58.85  ? 413 SER B O     1 
ATOM 341  C CB    . SER C 2 401 ? 199.154 250.435 222.214 1.00 58.85  ? 413 SER B CB    1 
ATOM 342  O OG    . SER C 2 401 ? 200.052 251.513 222.027 1.00 58.85  ? 413 SER B OG    1 
ATOM 343  N N     . VAL C 2 402 ? 198.514 251.397 225.741 1.00 60.89  ? 414 VAL B N     1 
ATOM 344  C CA    . VAL C 2 402 ? 198.126 252.512 226.594 1.00 60.89  ? 414 VAL B CA    1 
ATOM 345  C C     . VAL C 2 402 ? 199.281 252.826 227.533 1.00 60.89  ? 414 VAL B C     1 
ATOM 346  O O     . VAL C 2 402 ? 199.951 251.923 228.043 1.00 60.89  ? 414 VAL B O     1 
ATOM 347  C CB    . VAL C 2 402 ? 196.841 252.210 227.400 1.00 60.89  ? 414 VAL B CB    1 
ATOM 348  C CG1   . VAL C 2 402 ? 196.259 253.491 227.967 1.00 60.89  ? 414 VAL B CG1   1 
ATOM 349  C CG2   . VAL C 2 402 ? 195.818 251.490 226.536 1.00 60.89  ? 414 VAL B CG2   1 
ATOM 350  N N     . GLN C 2 403 ? 199.519 254.118 227.752 1.00 63.81  ? 415 GLN B N     1 
ATOM 351  C CA    . GLN C 2 403 ? 200.561 254.533 228.682 1.00 63.81  ? 415 GLN B CA    1 
ATOM 352  C C     . GLN C 2 403 ? 200.211 254.080 230.095 1.00 63.81  ? 415 GLN B C     1 
ATOM 353  O O     . GLN C 2 403 ? 199.063 254.203 230.533 1.00 63.81  ? 415 GLN B O     1 
ATOM 354  C CB    . GLN C 2 403 ? 200.750 256.049 228.631 1.00 63.81  ? 415 GLN B CB    1 
ATOM 355  C CG    . GLN C 2 403 ? 199.502 256.851 228.949 1.00 63.81  ? 415 GLN B CG    1 
ATOM 356  C CD    . GLN C 2 403 ? 199.560 258.255 228.391 1.00 63.81  ? 415 GLN B CD    1 
ATOM 357  O OE1   . GLN C 2 403 ? 198.755 258.629 227.540 1.00 63.81  ? 415 GLN B OE1   1 
ATOM 358  N NE2   . GLN C 2 403 ? 200.512 259.045 228.871 1.00 63.81  ? 415 GLN B NE2   1 
ATOM 359  N N     . ARG C 2 404 ? 201.199 253.541 230.804 1.00 62.42  ? 416 ARG B N     1 
ATOM 360  C CA    . ARG C 2 404 ? 200.958 252.934 232.104 1.00 62.42  ? 416 ARG B CA    1 
ATOM 361  C C     . ARG C 2 404 ? 202.270 252.859 232.874 1.00 62.42  ? 416 ARG B C     1 
ATOM 362  O O     . ARG C 2 404 ? 203.332 253.242 232.377 1.00 62.42  ? 416 ARG B O     1 
ATOM 363  C CB    . ARG C 2 404 ? 200.335 251.544 231.949 1.00 62.42  ? 416 ARG B CB    1 
ATOM 364  C CG    . ARG C 2 404 ? 201.019 250.690 230.895 1.00 62.42  ? 416 ARG B CG    1 
ATOM 365  C CD    . ARG C 2 404 ? 200.716 249.213 231.085 1.00 62.42  ? 416 ARG B CD    1 
ATOM 366  N NE    . ARG C 2 404 ? 199.433 248.834 230.506 1.00 62.42  ? 416 ARG B NE    1 
ATOM 367  C CZ    . ARG C 2 404 ? 199.199 248.726 229.205 1.00 62.42  ? 416 ARG B CZ    1 
ATOM 368  N NH1   . ARG C 2 404 ? 200.145 248.955 228.310 1.00 62.42  ? 416 ARG B NH1   1 
ATOM 369  N NH2   . ARG C 2 404 ? 197.984 248.377 228.792 1.00 62.42  ? 416 ARG B NH2   1 
ATOM 370  N N     . ASN C 2 405 ? 202.183 252.351 234.103 1.00 70.04  ? 417 ASN B N     1 
ATOM 371  C CA    . ASN C 2 405 ? 203.339 252.117 234.967 1.00 70.04  ? 417 ASN B CA    1 
ATOM 372  C C     . ASN C 2 405 ? 203.275 250.654 235.396 1.00 70.04  ? 417 ASN B C     1 
ATOM 373  O O     . ASN C 2 405 ? 202.636 250.317 236.395 1.00 70.04  ? 417 ASN B O     1 
ATOM 374  C CB    . ASN C 2 405 ? 203.348 253.074 236.159 1.00 70.04  ? 417 ASN B CB    1 
ATOM 375  C CG    . ASN C 2 405 ? 202.015 253.123 236.881 1.00 70.04  ? 417 ASN B CG    1 
ATOM 376  O OD1   . ASN C 2 405 ? 200.998 252.666 236.362 1.00 70.04  ? 417 ASN B OD1   1 
ATOM 377  N ND2   . ASN C 2 405 ? 202.015 253.680 238.087 1.00 70.04  ? 417 ASN B ND2   1 
ATOM 378  N N     . LEU C 2 406 ? 203.941 249.792 234.627 1.00 70.51  ? 418 LEU B N     1 
ATOM 379  C CA    . LEU C 2 406 ? 203.906 248.342 234.779 1.00 70.51  ? 418 LEU B CA    1 
ATOM 380  C C     . LEU C 2 406 ? 204.403 247.947 236.165 1.00 70.51  ? 418 LEU B C     1 
ATOM 381  O O     . LEU C 2 406 ? 205.600 248.063 236.455 1.00 70.51  ? 418 LEU B O     1 
ATOM 382  C CB    . LEU C 2 406 ? 204.747 247.670 233.689 1.00 70.51  ? 418 LEU B CB    1 
ATOM 383  C CG    . LEU C 2 406 ? 204.508 248.104 232.235 1.00 70.51  ? 418 LEU B CG    1 
ATOM 384  C CD1   . LEU C 2 406 ? 205.315 249.348 231.875 1.00 70.51  ? 418 LEU B CD1   1 
ATOM 385  C CD2   . LEU C 2 406 ? 204.802 246.983 231.250 1.00 70.51  ? 418 LEU B CD2   1 
ATOM 386  N N     . PRO C 2 407 ? 203.520 247.480 237.044 1.00 70.38  ? 419 PRO B N     1 
ATOM 387  C CA    . PRO C 2 407 ? 203.916 247.260 238.438 1.00 70.38  ? 419 PRO B CA    1 
ATOM 388  C C     . PRO C 2 407 ? 204.554 245.894 238.638 1.00 70.38  ? 419 PRO B C     1 
ATOM 389  O O     . PRO C 2 407 ? 204.181 244.910 237.996 1.00 70.38  ? 419 PRO B O     1 
ATOM 390  C CB    . PRO C 2 407 ? 202.588 247.363 239.202 1.00 70.38  ? 419 PRO B CB    1 
ATOM 391  C CG    . PRO C 2 407 ? 201.553 247.822 238.183 1.00 70.38  ? 419 PRO B CG    1 
ATOM 392  C CD    . PRO C 2 407 ? 202.067 247.350 236.866 1.00 70.38  ? 419 PRO B CD    1 
ATOM 393  N N     . PHE C 2 408 ? 205.526 245.843 239.551 1.00 78.39  ? 420 PHE B N     1 
ATOM 394  C CA    . PHE C 2 408 ? 206.134 244.593 239.990 1.00 78.39  ? 420 PHE B CA    1 
ATOM 395  C C     . PHE C 2 408 ? 206.222 244.584 241.509 1.00 78.39  ? 420 PHE B C     1 
ATOM 396  O O     . PHE C 2 408 ? 206.094 245.624 242.162 1.00 78.39  ? 420 PHE B O     1 
ATOM 397  C CB    . PHE C 2 408 ? 207.535 244.363 239.393 1.00 78.39  ? 420 PHE B CB    1 
ATOM 398  C CG    . PHE C 2 408 ? 207.763 245.039 238.069 1.00 78.39  ? 420 PHE B CG    1 
ATOM 399  C CD1   . PHE C 2 408 ? 207.031 244.677 236.959 1.00 78.39  ? 420 PHE B CD1   1 
ATOM 400  C CD2   . PHE C 2 408 ? 208.733 246.012 237.928 1.00 78.39  ? 420 PHE B CD2   1 
ATOM 401  C CE1   . PHE C 2 408 ? 207.243 245.289 235.751 1.00 78.39  ? 420 PHE B CE1   1 
ATOM 402  C CE2   . PHE C 2 408 ? 208.952 246.629 236.716 1.00 78.39  ? 420 PHE B CE2   1 
ATOM 403  C CZ    . PHE C 2 408 ? 208.204 246.264 235.623 1.00 78.39  ? 420 PHE B CZ    1 
ATOM 404  N N     . ASP C 2 409 ? 206.387 243.373 242.069 1.00 83.01  ? 421 ASP B N     1 
ATOM 405  C CA    . ASP C 2 409 ? 206.437 243.199 243.549 1.00 83.01  ? 421 ASP B CA    1 
ATOM 406  C C     . ASP C 2 409 ? 207.855 242.816 243.978 1.00 83.01  ? 421 ASP B C     1 
ATOM 407  O O     . ASP C 2 409 ? 208.101 241.614 244.200 1.00 83.01  ? 421 ASP B O     1 
ATOM 408  C CB    . ASP C 2 409 ? 205.414 242.166 244.024 1.00 83.01  ? 421 ASP B CB    1 
ATOM 409  C CG    . ASP C 2 409 ? 205.424 241.968 245.530 1.00 83.01  ? 421 ASP B CG    1 
ATOM 410  O OD1   . ASP C 2 409 ? 205.548 242.976 246.251 1.00 83.01  ? 421 ASP B OD1   1 
ATOM 411  O OD2   . ASP C 2 409 ? 205.312 240.807 245.968 1.00 83.01  ? 421 ASP B OD2   1 
ATOM 412  N N     . ARG C 2 410 ? 208.737 243.802 244.114 1.00 84.47  ? 422 ARG B N     1 
ATOM 413  C CA    . ARG C 2 410 ? 210.134 243.595 244.503 1.00 84.47  ? 422 ARG B CA    1 
ATOM 414  C C     . ARG C 2 410 ? 210.378 242.799 245.781 1.00 84.47  ? 422 ARG B C     1 
ATOM 415  O O     . ARG C 2 410 ? 211.337 242.006 245.789 1.00 84.47  ? 422 ARG B O     1 
ATOM 416  C CB    . ARG C 2 410 ? 210.857 244.945 244.589 1.00 84.47  ? 422 ARG B CB    1 
ATOM 417  C CG    . ARG C 2 410 ? 211.241 245.531 243.248 1.00 84.47  ? 422 ARG B CG    1 
ATOM 418  C CD    . ARG C 2 410 ? 210.091 246.022 242.430 1.00 84.47  ? 422 ARG B CD    1 
ATOM 419  N NE    . ARG C 2 410 ? 210.602 246.751 241.280 1.00 84.47  ? 422 ARG B NE    1 
ATOM 420  C CZ    . ARG C 2 410 ? 209.854 247.477 240.465 1.00 84.47  ? 422 ARG B CZ    1 
ATOM 421  N NH1   . ARG C 2 410 ? 208.541 247.545 240.614 1.00 84.47  ? 422 ARG B NH1   1 
ATOM 422  N NH2   . ARG C 2 410 ? 210.436 248.138 239.467 1.00 84.47  ? 422 ARG B NH2   1 
ATOM 423  N N     . PRO C 2 411 ? 209.607 242.948 246.882 1.00 89.33  ? 423 PRO B N     1 
ATOM 424  C CA    . PRO C 2 411 ? 209.939 242.195 248.105 1.00 89.33  ? 423 PRO B CA    1 
ATOM 425  C C     . PRO C 2 411 ? 210.149 240.697 247.915 1.00 89.33  ? 423 PRO B C     1 
ATOM 426  O O     . PRO C 2 411 ? 210.623 240.025 248.837 1.00 89.33  ? 423 PRO B O     1 
ATOM 427  C CB    . PRO C 2 411 ? 208.731 242.466 249.008 1.00 89.33  ? 423 PRO B CB    1 
ATOM 428  C CG    . PRO C 2 411 ? 208.318 243.820 248.624 1.00 89.33  ? 423 PRO B CG    1 
ATOM 429  C CD    . PRO C 2 411 ? 208.490 243.879 247.128 1.00 89.33  ? 423 PRO B CD    1 
ATOM 430  N N     . THR C 2 412 ? 209.802 240.157 246.745 1.00 87.13  ? 424 THR B N     1 
ATOM 431  C CA    . THR C 2 412 ? 210.079 238.759 246.437 1.00 87.13  ? 424 THR B CA    1 
ATOM 432  C C     . THR C 2 412 ? 210.759 238.537 245.088 1.00 87.13  ? 424 THR B C     1 
ATOM 433  O O     . THR C 2 412 ? 211.494 237.557 244.939 1.00 87.13  ? 424 THR B O     1 
ATOM 434  C CB    . THR C 2 412 ? 208.792 237.932 246.491 1.00 87.13  ? 424 THR B CB    1 
ATOM 435  O OG1   . THR C 2 412 ? 209.021 236.658 245.875 1.00 87.13  ? 424 THR B OG1   1 
ATOM 436  C CG2   . THR C 2 412 ? 207.669 238.639 245.774 1.00 87.13  ? 424 THR B CG2   1 
ATOM 437  N N     . ILE C 2 413 ? 210.533 239.397 244.088 1.00 84.30  ? 425 ILE B N     1 
ATOM 438  C CA    . ILE C 2 413 ? 211.112 239.137 242.769 1.00 84.30  ? 425 ILE B CA    1 
ATOM 439  C C     . ILE C 2 413 ? 212.582 239.541 242.731 1.00 84.30  ? 425 ILE B C     1 
ATOM 440  O O     . ILE C 2 413 ? 213.417 238.834 242.154 1.00 84.30  ? 425 ILE B O     1 
ATOM 441  C CB    . ILE C 2 413 ? 210.313 239.841 241.655 1.00 84.30  ? 425 ILE B CB    1 
ATOM 442  C CG1   . ILE C 2 413 ? 210.125 241.321 241.971 1.00 84.30  ? 425 ILE B CG1   1 
ATOM 443  C CG2   . ILE C 2 413 ? 208.971 239.163 241.446 1.00 84.30  ? 425 ILE B CG2   1 
ATOM 444  C CD1   . ILE C 2 413 ? 210.055 242.208 240.757 1.00 84.30  ? 425 ILE B CD1   1 
ATOM 445  N N     . MET C 2 414 ? 212.921 240.686 243.326 1.00 89.78  ? 426 MET B N     1 
ATOM 446  C CA    . MET C 2 414 ? 214.300 241.160 243.289 1.00 89.78  ? 426 MET B CA    1 
ATOM 447  C C     . MET C 2 414 ? 215.220 240.233 244.073 1.00 89.78  ? 426 MET B C     1 
ATOM 448  O O     . MET C 2 414 ? 216.362 239.986 243.669 1.00 89.78  ? 426 MET B O     1 
ATOM 449  C CB    . MET C 2 414 ? 214.378 242.586 243.833 1.00 89.78  ? 426 MET B CB    1 
ATOM 450  C CG    . MET C 2 414 ? 214.412 243.660 242.760 1.00 89.78  ? 426 MET B CG    1 
ATOM 451  S SD    . MET C 2 414 ? 215.022 245.233 243.392 1.00 89.78  ? 426 MET B SD    1 
ATOM 452  C CE    . MET C 2 414 ? 215.032 246.218 241.899 1.00 89.78  ? 426 MET B CE    1 
ATOM 453  N N     . ALA C 2 415 ? 214.739 239.710 245.195 1.00 89.91  ? 427 ALA B N     1 
ATOM 454  C CA    . ALA C 2 415 ? 215.550 238.864 246.063 1.00 89.91  ? 427 ALA B CA    1 
ATOM 455  C C     . ALA C 2 415 ? 215.880 237.519 245.450 1.00 89.91  ? 427 ALA B C     1 
ATOM 456  O O     . ALA C 2 415 ? 216.758 236.826 245.981 1.00 89.91  ? 427 ALA B O     1 
ATOM 457  C CB    . ALA C 2 415 ? 214.839 238.665 247.402 1.00 89.91  ? 427 ALA B CB    1 
ATOM 458  N N     . ALA C 2 416 ? 215.228 237.118 244.364 1.00 88.01  ? 428 ALA B N     1 
ATOM 459  C CA    . ALA C 2 416 ? 215.528 235.845 243.724 1.00 88.01  ? 428 ALA B CA    1 
ATOM 460  C C     . ALA C 2 416 ? 215.789 236.036 242.234 1.00 88.01  ? 428 ALA B C     1 
ATOM 461  O O     . ALA C 2 416 ? 216.199 237.113 241.800 1.00 88.01  ? 428 ALA B O     1 
ATOM 462  C CB    . ALA C 2 416 ? 214.392 234.860 243.944 1.00 88.01  ? 428 ALA B CB    1 
ATOM 463  N N     . ASP D 2 4   ? 206.731 254.487 203.242 1.00 71.94  ? 16  ASP A N     1 
ATOM 464  C CA    . ASP D 2 4   ? 205.501 253.770 203.556 1.00 71.94  ? 16  ASP A CA    1 
ATOM 465  C C     . ASP D 2 4   ? 204.943 253.042 202.339 1.00 71.94  ? 16  ASP A C     1 
ATOM 466  O O     . ASP D 2 4   ? 203.923 253.440 201.779 1.00 71.94  ? 16  ASP A O     1 
ATOM 467  C CB    . ASP D 2 4   ? 204.447 254.730 204.113 1.00 71.94  ? 16  ASP A CB    1 
ATOM 468  C CG    . ASP D 2 4   ? 204.234 254.559 205.603 1.00 71.94  ? 16  ASP A CG    1 
ATOM 469  O OD1   . ASP D 2 4   ? 205.001 253.801 206.231 1.00 71.94  ? 16  ASP A OD1   1 
ATOM 470  O OD2   . ASP D 2 4   ? 203.297 255.181 206.144 1.00 71.94  ? 16  ASP A OD2   1 
ATOM 471  N N     . GLY D 2 5   ? 205.619 251.971 201.936 1.00 71.46  ? 17  GLY A N     1 
ATOM 472  C CA    . GLY D 2 5   ? 205.133 251.145 200.850 1.00 71.46  ? 17  GLY A CA    1 
ATOM 473  C C     . GLY D 2 5   ? 204.354 249.948 201.352 1.00 71.46  ? 17  GLY A C     1 
ATOM 474  O O     . GLY D 2 5   ? 204.050 249.028 200.588 1.00 71.46  ? 17  GLY A O     1 
ATOM 475  N N     . GLU D 2 6   ? 204.005 249.966 202.639 1.00 74.34  ? 18  GLU A N     1 
ATOM 476  C CA    . GLU D 2 6   ? 203.303 248.799 203.236 1.00 74.34  ? 18  GLU A CA    1 
ATOM 477  C C     . GLU D 2 6   ? 201.797 248.897 202.963 1.00 74.34  ? 18  GLU A C     1 
ATOM 478  O O     . GLU D 2 6   ? 201.113 247.878 203.133 1.00 74.34  ? 18  GLU A O     1 
ATOM 479  C CB    . GLU D 2 6   ? 203.620 248.710 204.731 1.00 74.34  ? 18  GLU A CB    1 
ATOM 480  C CG    . GLU D 2 6   ? 205.078 248.424 205.033 1.00 74.34  ? 18  GLU A CG    1 
ATOM 481  C CD    . GLU D 2 6   ? 205.594 247.138 204.413 1.00 74.34  ? 18  GLU A CD    1 
ATOM 482  O OE1   . GLU D 2 6   ? 204.845 246.142 204.417 1.00 74.34  ? 18  GLU A OE1   1 
ATOM 483  O OE2   . GLU D 2 6   ? 206.741 247.138 203.922 1.00 74.34  ? 18  GLU A OE2   1 
ATOM 484  N N     . ARG D 2 7   ? 201.300 250.064 202.539 1.00 73.89  ? 19  ARG A N     1 
ATOM 485  C CA    . ARG D 2 7   ? 199.860 250.207 202.355 1.00 73.89  ? 19  ARG A CA    1 
ATOM 486  C C     . ARG D 2 7   ? 199.289 249.092 201.490 1.00 73.89  ? 19  ARG A C     1 
ATOM 487  O O     . ARG D 2 7   ? 198.229 248.546 201.811 1.00 73.89  ? 19  ARG A O     1 
ATOM 488  C CB    . ARG D 2 7   ? 199.530 251.570 201.746 1.00 73.89  ? 19  ARG A CB    1 
ATOM 489  C CG    . ARG D 2 7   ? 198.039 251.853 201.630 1.00 73.89  ? 19  ARG A CG    1 
ATOM 490  C CD    . ARG D 2 7   ? 197.771 253.257 201.110 1.00 73.89  ? 19  ARG A CD    1 
ATOM 491  N NE    . ARG D 2 7   ? 196.345 253.527 200.975 1.00 73.89  ? 19  ARG A NE    1 
ATOM 492  C CZ    . ARG D 2 7   ? 195.557 253.915 201.968 1.00 73.89  ? 19  ARG A CZ    1 
ATOM 493  N NH1   . ARG D 2 7   ? 196.025 254.086 203.194 1.00 73.89  ? 19  ARG A NH1   1 
ATOM 494  N NH2   . ARG D 2 7   ? 194.269 254.140 201.726 1.00 73.89  ? 19  ARG A NH2   1 
ATOM 495  N N     . GLN D 2 8   ? 199.969 248.739 200.396 1.00 73.44  ? 20  GLN A N     1 
ATOM 496  C CA    . GLN D 2 8   ? 199.528 247.597 199.601 1.00 73.44  ? 20  GLN A CA    1 
ATOM 497  C C     . GLN D 2 8   ? 199.611 246.306 200.405 1.00 73.44  ? 20  GLN A C     1 
ATOM 498  O O     . GLN D 2 8   ? 198.681 245.490 200.384 1.00 73.44  ? 20  GLN A O     1 
ATOM 499  C CB    . GLN D 2 8   ? 200.361 247.490 198.325 1.00 73.44  ? 20  GLN A CB    1 
ATOM 500  C CG    . GLN D 2 8   ? 199.794 246.526 197.296 1.00 73.44  ? 20  GLN A CG    1 
ATOM 501  C CD    . GLN D 2 8   ? 198.390 246.897 196.861 1.00 73.44  ? 20  GLN A CD    1 
ATOM 502  O OE1   . GLN D 2 8   ? 198.058 248.075 196.733 1.00 73.44  ? 20  GLN A OE1   1 
ATOM 503  N NE2   . GLN D 2 8   ? 197.557 245.889 196.631 1.00 73.44  ? 20  GLN A NE2   1 
ATOM 504  N N     . ASN D 2 9   ? 200.715 246.109 201.129 1.00 73.64  ? 21  ASN A N     1 
ATOM 505  C CA    . ASN D 2 9   ? 200.859 244.911 201.949 1.00 73.64  ? 21  ASN A CA    1 
ATOM 506  C C     . ASN D 2 9   ? 199.829 244.881 203.072 1.00 73.64  ? 21  ASN A C     1 
ATOM 507  O O     . ASN D 2 9   ? 199.236 243.831 203.349 1.00 73.64  ? 21  ASN A O     1 
ATOM 508  C CB    . ASN D 2 9   ? 202.278 244.834 202.512 1.00 73.64  ? 21  ASN A CB    1 
ATOM 509  C CG    . ASN D 2 9   ? 202.720 243.412 202.784 1.00 73.64  ? 21  ASN A CG    1 
ATOM 510  O OD1   . ASN D 2 9   ? 201.999 242.458 202.491 1.00 73.64  ? 21  ASN A OD1   1 
ATOM 511  N ND2   . ASN D 2 9   ? 203.915 243.260 203.341 1.00 73.64  ? 21  ASN A ND2   1 
ATOM 512  N N     . ALA D 2 10  ? 199.601 246.022 203.727 1.00 70.97  ? 22  ALA A N     1 
ATOM 513  C CA    . ALA D 2 10  ? 198.603 246.078 204.791 1.00 70.97  ? 22  ALA A CA    1 
ATOM 514  C C     . ALA D 2 10  ? 197.207 245.793 204.254 1.00 70.97  ? 22  ALA A C     1 
ATOM 515  O O     . ALA D 2 10  ? 196.422 245.085 204.894 1.00 70.97  ? 22  ALA A O     1 
ATOM 516  C CB    . ALA D 2 10  ? 198.642 247.440 205.483 1.00 70.97  ? 22  ALA A CB    1 
ATOM 517  N N     . THR D 2 11  ? 196.879 246.337 203.080 1.00 72.13  ? 23  THR A N     1 
ATOM 518  C CA    . THR D 2 11  ? 195.577 246.068 202.478 1.00 72.13  ? 23  THR A CA    1 
ATOM 519  C C     . THR D 2 11  ? 195.435 244.598 202.101 1.00 72.13  ? 23  THR A C     1 
ATOM 520  O O     . THR D 2 11  ? 194.360 244.012 202.269 1.00 72.13  ? 23  THR A O     1 
ATOM 521  C CB    . THR D 2 11  ? 195.367 246.959 201.256 1.00 72.13  ? 23  THR A CB    1 
ATOM 522  O OG1   . THR D 2 11  ? 195.845 248.280 201.539 1.00 72.13  ? 23  THR A OG1   1 
ATOM 523  C CG2   . THR D 2 11  ? 193.890 247.029 200.899 1.00 72.13  ? 23  THR A CG2   1 
ATOM 524  N N     . GLU D 2 12  ? 196.505 243.985 201.588 1.00 73.12  ? 24  GLU A N     1 
ATOM 525  C CA    . GLU D 2 12  ? 196.452 242.562 201.267 1.00 73.12  ? 24  GLU A CA    1 
ATOM 526  C C     . GLU D 2 12  ? 196.234 241.719 202.518 1.00 73.12  ? 24  GLU A C     1 
ATOM 527  O O     . GLU D 2 12  ? 195.438 240.772 202.507 1.00 73.12  ? 24  GLU A O     1 
ATOM 528  C CB    . GLU D 2 12  ? 197.731 242.133 200.550 1.00 73.12  ? 24  GLU A CB    1 
ATOM 529  C CG    . GLU D 2 12  ? 197.791 242.539 199.090 1.00 73.12  ? 24  GLU A CG    1 
ATOM 530  C CD    . GLU D 2 12  ? 199.081 242.114 198.422 1.00 73.12  ? 24  GLU A CD    1 
ATOM 531  O OE1   . GLU D 2 12  ? 199.991 241.641 199.135 1.00 73.12  ? 24  GLU A OE1   1 
ATOM 532  O OE2   . GLU D 2 12  ? 199.187 242.252 197.186 1.00 73.12  ? 24  GLU A OE2   1 
ATOM 533  N N     . ILE D 2 13  ? 196.931 242.048 203.607 1.00 71.56  ? 25  ILE A N     1 
ATOM 534  C CA    . ILE D 2 13  ? 196.753 241.301 204.849 1.00 71.56  ? 25  ILE A CA    1 
ATOM 535  C C     . ILE D 2 13  ? 195.346 241.500 205.399 1.00 71.56  ? 25  ILE A C     1 
ATOM 536  O O     . ILE D 2 13  ? 194.726 240.560 205.915 1.00 71.56  ? 25  ILE A O     1 
ATOM 537  C CB    . ILE D 2 13  ? 197.831 241.698 205.875 1.00 71.56  ? 25  ILE A CB    1 
ATOM 538  C CG1   . ILE D 2 13  ? 199.225 241.418 205.314 1.00 71.56  ? 25  ILE A CG1   1 
ATOM 539  C CG2   . ILE D 2 13  ? 197.627 240.955 207.186 1.00 71.56  ? 25  ILE A CG2   1 
ATOM 540  C CD1   . ILE D 2 13  ? 199.582 239.950 205.273 1.00 71.56  ? 25  ILE A CD1   1 
ATOM 541  N N     . ARG D 2 14  ? 194.819 242.723 205.299 1.00 72.30  ? 26  ARG A N     1 
ATOM 542  C CA    . ARG D 2 14  ? 193.452 242.980 205.739 1.00 72.30  ? 26  ARG A CA    1 
ATOM 543  C C     . ARG D 2 14  ? 192.456 242.166 204.924 1.00 72.30  ? 26  ARG A C     1 
ATOM 544  O O     . ARG D 2 14  ? 191.516 241.585 205.478 1.00 72.30  ? 26  ARG A O     1 
ATOM 545  C CB    . ARG D 2 14  ? 193.141 244.472 205.634 1.00 72.30  ? 26  ARG A CB    1 
ATOM 546  C CG    . ARG D 2 14  ? 193.632 245.292 206.814 1.00 72.30  ? 26  ARG A CG    1 
ATOM 547  C CD    . ARG D 2 14  ? 193.141 246.727 206.737 1.00 72.30  ? 26  ARG A CD    1 
ATOM 548  N NE    . ARG D 2 14  ? 192.288 247.071 207.867 1.00 72.30  ? 26  ARG A NE    1 
ATOM 549  C CZ    . ARG D 2 14  ? 190.964 247.122 207.816 1.00 72.30  ? 26  ARG A CZ    1 
ATOM 550  N NH1   . ARG D 2 14  ? 190.304 246.856 206.701 1.00 72.30  ? 26  ARG A NH1   1 
ATOM 551  N NH2   . ARG D 2 14  ? 190.285 247.447 208.913 1.00 72.30  ? 26  ARG A NH2   1 
ATOM 552  N N     . ALA D 2 15  ? 192.654 242.103 203.606 1.00 72.53  ? 27  ALA A N     1 
ATOM 553  C CA    . ALA D 2 15  ? 191.775 241.302 202.762 1.00 72.53  ? 27  ALA A CA    1 
ATOM 554  C C     . ALA D 2 15  ? 191.863 239.823 203.118 1.00 72.53  ? 27  ALA A C     1 
ATOM 555  O O     . ALA D 2 15  ? 190.844 239.126 203.156 1.00 72.53  ? 27  ALA A O     1 
ATOM 556  C CB    . ALA D 2 15  ? 192.119 241.522 201.289 1.00 72.53  ? 27  ALA A CB    1 
ATOM 557  N N     . SER D 2 16  ? 193.072 239.326 203.385 1.00 72.28  ? 28  SER A N     1 
ATOM 558  C CA    . SER D 2 16  ? 193.236 237.914 203.722 1.00 72.28  ? 28  SER A CA    1 
ATOM 559  C C     . SER D 2 16  ? 192.549 237.573 205.041 1.00 72.28  ? 28  SER A C     1 
ATOM 560  O O     . SER D 2 16  ? 191.839 236.562 205.142 1.00 72.28  ? 28  SER A O     1 
ATOM 561  C CB    . SER D 2 16  ? 194.721 237.559 203.781 1.00 72.28  ? 28  SER A CB    1 
ATOM 562  O OG    . SER D 2 16  ? 195.350 238.180 204.887 1.00 72.28  ? 28  SER A OG    1 
ATOM 563  N N     . VAL D 2 17  ? 192.749 238.402 206.068 1.00 71.44  ? 29  VAL A N     1 
ATOM 564  C CA    . VAL D 2 17  ? 192.115 238.117 207.351 1.00 71.44  ? 29  VAL A CA    1 
ATOM 565  C C     . VAL D 2 17  ? 190.601 238.274 207.252 1.00 71.44  ? 29  VAL A C     1 
ATOM 566  O O     . VAL D 2 17  ? 189.851 237.517 207.882 1.00 71.44  ? 29  VAL A O     1 
ATOM 567  C CB    . VAL D 2 17  ? 192.715 238.986 208.474 1.00 71.44  ? 29  VAL A CB    1 
ATOM 568  C CG1   . VAL D 2 17  ? 194.204 238.711 208.617 1.00 71.44  ? 29  VAL A CG1   1 
ATOM 569  C CG2   . VAL D 2 17  ? 192.469 240.455 208.225 1.00 71.44  ? 29  VAL A CG2   1 
ATOM 570  N N     . GLY D 2 18  ? 190.121 239.235 206.457 1.00 73.15  ? 30  GLY A N     1 
ATOM 571  C CA    . GLY D 2 18  ? 188.690 239.347 206.238 1.00 73.15  ? 30  GLY A CA    1 
ATOM 572  C C     . GLY D 2 18  ? 188.117 238.134 205.532 1.00 73.15  ? 30  GLY A C     1 
ATOM 573  O O     . GLY D 2 18  ? 187.019 237.678 205.854 1.00 73.15  ? 30  GLY A O     1 
ATOM 574  N N     . LYS D 2 19  ? 188.855 237.594 204.560 1.00 77.80  ? 31  LYS A N     1 
ATOM 575  C CA    . LYS D 2 19  ? 188.416 236.379 203.885 1.00 77.80  ? 31  LYS A CA    1 
ATOM 576  C C     . LYS D 2 19  ? 188.354 235.205 204.853 1.00 77.80  ? 31  LYS A C     1 
ATOM 577  O O     . LYS D 2 19  ? 187.407 234.411 204.813 1.00 77.80  ? 31  LYS A O     1 
ATOM 578  C CB    . LYS D 2 19  ? 189.345 236.069 202.709 1.00 77.80  ? 31  LYS A CB    1 
ATOM 579  C CG    . LYS D 2 19  ? 189.707 234.598 202.553 1.00 77.80  ? 31  LYS A CG    1 
ATOM 580  C CD    . LYS D 2 19  ? 190.228 234.294 201.155 1.00 77.80  ? 31  LYS A CD    1 
ATOM 581  C CE    . LYS D 2 19  ? 191.159 235.387 200.653 1.00 77.80  ? 31  LYS A CE    1 
ATOM 582  N NZ    . LYS D 2 19  ? 191.581 235.154 199.243 1.00 77.80  ? 31  LYS A NZ    1 
ATOM 583  N N     . MET D 2 20  ? 189.350 235.081 205.734 1.00 74.61  ? 32  MET A N     1 
ATOM 584  C CA    . MET D 2 20  ? 189.322 233.994 206.711 1.00 74.61  ? 32  MET A CA    1 
ATOM 585  C C     . MET D 2 20  ? 188.139 234.147 207.664 1.00 74.61  ? 32  MET A C     1 
ATOM 586  O O     . MET D 2 20  ? 187.460 233.164 207.989 1.00 74.61  ? 32  MET A O     1 
ATOM 587  C CB    . MET D 2 20  ? 190.641 233.933 207.484 1.00 74.61  ? 32  MET A CB    1 
ATOM 588  C CG    . MET D 2 20  ? 190.487 233.646 208.972 1.00 74.61  ? 32  MET A CG    1 
ATOM 589  S SD    . MET D 2 20  ? 191.988 233.926 209.931 1.00 74.61  ? 32  MET A SD    1 
ATOM 590  C CE    . MET D 2 20  ? 191.989 235.709 210.056 1.00 74.61  ? 32  MET A CE    1 
ATOM 591  N N     . ILE D 2 21  ? 187.872 235.377 208.111 1.00 73.06  ? 33  ILE A N     1 
ATOM 592  C CA    . ILE D 2 21  ? 186.748 235.616 209.015 1.00 73.06  ? 33  ILE A CA    1 
ATOM 593  C C     . ILE D 2 21  ? 185.427 235.306 208.321 1.00 73.06  ? 33  ILE A C     1 
ATOM 594  O O     . ILE D 2 21  ? 184.521 234.706 208.914 1.00 73.06  ? 33  ILE A O     1 
ATOM 595  C CB    . ILE D 2 21  ? 186.791 237.062 209.543 1.00 73.06  ? 33  ILE A CB    1 
ATOM 596  C CG1   . ILE D 2 21  ? 187.961 237.243 210.513 1.00 73.06  ? 33  ILE A CG1   1 
ATOM 597  C CG2   . ILE D 2 21  ? 185.485 237.425 210.226 1.00 73.06  ? 33  ILE A CG2   1 
ATOM 598  C CD1   . ILE D 2 21  ? 188.166 236.080 211.458 1.00 73.06  ? 33  ILE A CD1   1 
ATOM 599  N N     . ASP D 2 22  ? 185.294 235.713 207.056 1.00 77.22  ? 34  ASP A N     1 
ATOM 600  C CA    . ASP D 2 22  ? 184.081 235.419 206.299 1.00 77.22  ? 34  ASP A CA    1 
ATOM 601  C C     . ASP D 2 22  ? 183.893 233.919 206.120 1.00 77.22  ? 34  ASP A C     1 
ATOM 602  O O     . ASP D 2 22  ? 182.770 233.408 206.227 1.00 77.22  ? 34  ASP A O     1 
ATOM 603  C CB    . ASP D 2 22  ? 184.132 236.122 204.943 1.00 77.22  ? 34  ASP A CB    1 
ATOM 604  C CG    . ASP D 2 22  ? 183.139 235.552 203.953 1.00 77.22  ? 34  ASP A CG    1 
ATOM 605  O OD1   . ASP D 2 22  ? 181.938 235.880 204.057 1.00 77.22  ? 34  ASP A OD1   1 
ATOM 606  O OD2   . ASP D 2 22  ? 183.559 234.777 203.069 1.00 77.22  ? 34  ASP A OD2   1 
ATOM 607  N N     . GLY D 2 23  ? 184.979 233.197 205.836 1.00 74.32  ? 35  GLY A N     1 
ATOM 608  C CA    . GLY D 2 23  ? 184.884 231.752 205.731 1.00 74.32  ? 35  GLY A CA    1 
ATOM 609  C C     . GLY D 2 23  ? 184.443 231.106 207.030 1.00 74.32  ? 35  GLY A C     1 
ATOM 610  O O     . GLY D 2 23  ? 183.596 230.210 207.031 1.00 74.32  ? 35  GLY A O     1 
ATOM 611  N N     . ILE D 2 24  ? 184.999 231.565 208.154 1.00 70.85  ? 36  ILE A N     1 
ATOM 612  C CA    . ILE D 2 24  ? 184.595 231.038 209.456 1.00 70.85  ? 36  ILE A CA    1 
ATOM 613  C C     . ILE D 2 24  ? 183.114 231.303 209.703 1.00 70.85  ? 36  ILE A C     1 
ATOM 614  O O     . ILE D 2 24  ? 182.375 230.421 210.163 1.00 70.85  ? 36  ILE A O     1 
ATOM 615  C CB    . ILE D 2 24  ? 185.469 231.641 210.571 1.00 70.85  ? 36  ILE A CB    1 
ATOM 616  C CG1   . ILE D 2 24  ? 186.905 231.130 210.465 1.00 70.85  ? 36  ILE A CG1   1 
ATOM 617  C CG2   . ILE D 2 24  ? 184.894 231.315 211.940 1.00 70.85  ? 36  ILE A CG2   1 
ATOM 618  C CD1   . ILE D 2 24  ? 187.825 231.708 211.514 1.00 70.85  ? 36  ILE A CD1   1 
ATOM 619  N N     . GLY D 2 25  ? 182.659 232.521 209.402 1.00 72.43  ? 37  GLY A N     1 
ATOM 620  C CA    . GLY D 2 25  ? 181.262 232.856 209.634 1.00 72.43  ? 37  GLY A CA    1 
ATOM 621  C C     . GLY D 2 25  ? 180.314 232.028 208.789 1.00 72.43  ? 37  GLY A C     1 
ATOM 622  O O     . GLY D 2 25  ? 179.306 231.513 209.284 1.00 72.43  ? 37  GLY A O     1 
ATOM 623  N N     . ARG D 2 26  ? 180.623 231.885 207.498 1.00 72.81  ? 38  ARG A N     1 
ATOM 624  C CA    . ARG D 2 26  ? 179.772 231.076 206.632 1.00 72.81  ? 38  ARG A CA    1 
ATOM 625  C C     . ARG D 2 26  ? 179.798 229.608 207.036 1.00 72.81  ? 38  ARG A C     1 
ATOM 626  O O     . ARG D 2 26  ? 178.776 228.919 206.937 1.00 72.81  ? 38  ARG A O     1 
ATOM 627  C CB    . ARG D 2 26  ? 180.188 231.239 205.171 1.00 72.81  ? 38  ARG A CB    1 
ATOM 628  C CG    . ARG D 2 26  ? 180.051 232.659 204.652 1.00 72.81  ? 38  ARG A CG    1 
ATOM 629  C CD    . ARG D 2 26  ? 180.761 232.833 203.324 1.00 72.81  ? 38  ARG A CD    1 
ATOM 630  N NE    . ARG D 2 26  ? 180.735 231.608 202.534 1.00 72.81  ? 38  ARG A NE    1 
ATOM 631  C CZ    . ARG D 2 26  ? 181.800 231.063 201.965 1.00 72.81  ? 38  ARG A CZ    1 
ATOM 632  N NH1   . ARG D 2 26  ? 182.999 231.612 202.073 1.00 72.81  ? 38  ARG A NH1   1 
ATOM 633  N NH2   . ARG D 2 26  ? 181.660 229.938 201.271 1.00 72.81  ? 38  ARG A NH2   1 
ATOM 634  N N     . PHE D 2 27  ? 180.947 229.113 207.500 1.00 73.82  ? 39  PHE A N     1 
ATOM 635  C CA    . PHE D 2 27  ? 181.017 227.741 207.985 1.00 73.82  ? 39  PHE A CA    1 
ATOM 636  C C     . PHE D 2 27  ? 180.129 227.543 209.207 1.00 73.82  ? 39  PHE A C     1 
ATOM 637  O O     . PHE D 2 27  ? 179.422 226.533 209.316 1.00 73.82  ? 39  PHE A O     1 
ATOM 638  C CB    . PHE D 2 27  ? 182.467 227.389 208.308 1.00 73.82  ? 39  PHE A CB    1 
ATOM 639  C CG    . PHE D 2 27  ? 182.628 226.092 209.030 1.00 73.82  ? 39  PHE A CG    1 
ATOM 640  C CD1   . PHE D 2 27  ? 182.685 224.901 208.332 1.00 73.82  ? 39  PHE A CD1   1 
ATOM 641  C CD2   . PHE D 2 27  ? 182.726 226.064 210.406 1.00 73.82  ? 39  PHE A CD2   1 
ATOM 642  C CE1   . PHE D 2 27  ? 182.838 223.707 208.996 1.00 73.82  ? 39  PHE A CE1   1 
ATOM 643  C CE2   . PHE D 2 27  ? 182.869 224.878 211.069 1.00 73.82  ? 39  PHE A CE2   1 
ATOM 644  C CZ    . PHE D 2 27  ? 182.935 223.698 210.365 1.00 73.82  ? 39  PHE A CZ    1 
ATOM 645  N N     . TYR D 2 28  ? 180.159 228.495 210.142 1.00 73.08  ? 40  TYR A N     1 
ATOM 646  C CA    . TYR D 2 28  ? 179.293 228.393 211.312 1.00 73.08  ? 40  TYR A CA    1 
ATOM 647  C C     . TYR D 2 28  ? 177.826 228.466 210.913 1.00 73.08  ? 40  TYR A C     1 
ATOM 648  O O     . TYR D 2 28  ? 176.982 227.777 211.496 1.00 73.08  ? 40  TYR A O     1 
ATOM 649  C CB    . TYR D 2 28  ? 179.626 229.488 212.323 1.00 73.08  ? 40  TYR A CB    1 
ATOM 650  C CG    . TYR D 2 28  ? 178.863 229.349 213.620 1.00 73.08  ? 40  TYR A CG    1 
ATOM 651  C CD1   . TYR D 2 28  ? 179.237 228.408 214.569 1.00 73.08  ? 40  TYR A CD1   1 
ATOM 652  C CD2   . TYR D 2 28  ? 177.765 230.153 213.893 1.00 73.08  ? 40  TYR A CD2   1 
ATOM 653  C CE1   . TYR D 2 28  ? 178.544 228.275 215.754 1.00 73.08  ? 40  TYR A CE1   1 
ATOM 654  C CE2   . TYR D 2 28  ? 177.064 230.026 215.077 1.00 73.08  ? 40  TYR A CE2   1 
ATOM 655  C CZ    . TYR D 2 28  ? 177.458 229.084 216.002 1.00 73.08  ? 40  TYR A CZ    1 
ATOM 656  O OH    . TYR D 2 28  ? 176.766 228.952 217.184 1.00 73.08  ? 40  TYR A OH    1 
ATOM 657  N N     . ILE D 2 29  ? 177.504 229.301 209.923 1.00 73.61  ? 41  ILE A N     1 
ATOM 658  C CA    . ILE D 2 29  ? 176.130 229.379 209.434 1.00 73.61  ? 41  ILE A CA    1 
ATOM 659  C C     . ILE D 2 29  ? 175.696 228.041 208.848 1.00 73.61  ? 41  ILE A C     1 
ATOM 660  O O     . ILE D 2 29  ? 174.580 227.571 209.096 1.00 73.61  ? 41  ILE A O     1 
ATOM 661  C CB    . ILE D 2 29  ? 175.990 230.519 208.409 1.00 73.61  ? 41  ILE A CB    1 
ATOM 662  C CG1   . ILE D 2 29  ? 175.999 231.874 209.116 1.00 73.61  ? 41  ILE A CG1   1 
ATOM 663  C CG2   . ILE D 2 29  ? 174.719 230.355 207.590 1.00 73.61  ? 41  ILE A CG2   1 
ATOM 664  C CD1   . ILE D 2 29  ? 175.617 233.028 208.219 1.00 73.61  ? 41  ILE A CD1   1 
ATOM 665  N N     . GLN D 2 30  ? 176.570 227.409 208.061 1.00 76.53  ? 42  GLN A N     1 
ATOM 666  C CA    . GLN D 2 30  ? 176.257 226.102 207.489 1.00 76.53  ? 42  GLN A CA    1 
ATOM 667  C C     . GLN D 2 30  ? 176.032 225.072 208.591 1.00 76.53  ? 42  GLN A C     1 
ATOM 668  O O     . GLN D 2 30  ? 175.073 224.292 208.547 1.00 76.53  ? 42  GLN A O     1 
ATOM 669  C CB    . GLN D 2 30  ? 177.398 225.667 206.564 1.00 76.53  ? 42  GLN A CB    1 
ATOM 670  C CG    . GLN D 2 30  ? 177.245 224.332 205.819 1.00 76.53  ? 42  GLN A CG    1 
ATOM 671  C CD    . GLN D 2 30  ? 175.821 224.009 205.395 1.00 76.53  ? 42  GLN A CD    1 
ATOM 672  O OE1   . GLN D 2 30  ? 175.056 223.397 206.135 1.00 76.53  ? 42  GLN A OE1   1 
ATOM 673  N NE2   . GLN D 2 30  ? 175.466 224.417 204.183 1.00 76.53  ? 42  GLN A NE2   1 
ATOM 674  N N     . MET D 2 31  ? 176.906 225.067 209.599 1.00 78.37  ? 43  MET A N     1 
ATOM 675  C CA    . MET D 2 31  ? 176.781 224.094 210.681 1.00 78.37  ? 43  MET A CA    1 
ATOM 676  C C     . MET D 2 31  ? 175.488 224.305 211.462 1.00 78.37  ? 43  MET A C     1 
ATOM 677  O O     . MET D 2 31  ? 174.797 223.343 211.814 1.00 78.37  ? 43  MET A O     1 
ATOM 678  C CB    . MET D 2 31  ? 177.998 224.178 211.601 1.00 78.37  ? 43  MET A CB    1 
ATOM 679  C CG    . MET D 2 31  ? 178.383 222.848 212.222 1.00 78.37  ? 43  MET A CG    1 
ATOM 680  S SD    . MET D 2 31  ? 178.648 221.568 210.980 1.00 78.37  ? 43  MET A SD    1 
ATOM 681  C CE    . MET D 2 31  ? 180.420 221.603 210.822 1.00 78.37  ? 43  MET A CE    1 
ATOM 682  N N     . CYS D 2 32  ? 175.144 225.565 211.738 1.00 81.00  ? 44  CYS A N     1 
ATOM 683  C CA    . CYS D 2 32  ? 173.891 225.865 212.424 1.00 81.00  ? 44  CYS A CA    1 
ATOM 684  C C     . CYS D 2 32  ? 172.683 225.462 211.586 1.00 81.00  ? 44  CYS A C     1 
ATOM 685  O O     . CYS D 2 32  ? 171.697 224.937 212.116 1.00 81.00  ? 44  CYS A O     1 
ATOM 686  C CB    . CYS D 2 32  ? 173.831 227.354 212.769 1.00 81.00  ? 44  CYS A CB    1 
ATOM 687  S SG    . CYS D 2 32  ? 172.881 227.749 214.254 1.00 81.00  ? 44  CYS A SG    1 
ATOM 688  N N     . THR D 2 33  ? 172.739 225.704 210.274 1.00 79.50  ? 45  THR A N     1 
ATOM 689  C CA    . THR D 2 33  ? 171.629 225.341 209.399 1.00 79.50  ? 45  THR A CA    1 
ATOM 690  C C     . THR D 2 33  ? 171.431 223.833 209.368 1.00 79.50  ? 45  THR A C     1 
ATOM 691  O O     . THR D 2 33  ? 170.297 223.341 209.418 1.00 79.50  ? 45  THR A O     1 
ATOM 692  C CB    . THR D 2 33  ? 171.879 225.880 207.988 1.00 79.50  ? 45  THR A CB    1 
ATOM 693  O OG1   . THR D 2 33  ? 171.982 227.308 208.031 1.00 79.50  ? 45  THR A OG1   1 
ATOM 694  C CG2   . THR D 2 33  ? 170.750 225.478 207.041 1.00 79.50  ? 45  THR A CG2   1 
ATOM 695  N N     . GLU D 2 34  ? 172.529 223.082 209.296 1.00 83.46  ? 46  GLU A N     1 
ATOM 696  C CA    . GLU D 2 34  ? 172.430 221.634 209.186 1.00 83.46  ? 46  GLU A CA    1 
ATOM 697  C C     . GLU D 2 34  ? 172.067 220.989 210.520 1.00 83.46  ? 46  GLU A C     1 
ATOM 698  O O     . GLU D 2 34  ? 171.411 219.942 210.537 1.00 83.46  ? 46  GLU A O     1 
ATOM 699  C CB    . GLU D 2 34  ? 173.737 221.091 208.571 1.00 83.46  ? 46  GLU A CB    1 
ATOM 700  C CG    . GLU D 2 34  ? 173.887 219.573 208.270 1.00 83.46  ? 46  GLU A CG    1 
ATOM 701  C CD    . GLU D 2 34  ? 175.198 219.155 207.621 1.00 83.46  ? 46  GLU A CD    1 
ATOM 702  O OE1   . GLU D 2 34  ? 176.067 220.021 207.409 1.00 83.46  ? 46  GLU A OE1   1 
ATOM 703  O OE2   . GLU D 2 34  ? 175.322 217.984 207.210 1.00 83.46  ? 46  GLU A OE2   1 
ATOM 704  N N     . LEU D 2 35  ? 172.484 221.587 211.640 1.00 81.03  ? 47  LEU A N     1 
ATOM 705  C CA    . LEU D 2 35  ? 172.215 221.016 212.955 1.00 81.03  ? 47  LEU A CA    1 
ATOM 706  C C     . LEU D 2 35  ? 170.867 221.432 213.530 1.00 81.03  ? 47  LEU A C     1 
ATOM 707  O O     . LEU D 2 35  ? 170.511 220.962 214.616 1.00 81.03  ? 47  LEU A O     1 
ATOM 708  C CB    . LEU D 2 35  ? 173.327 221.398 213.934 1.00 81.03  ? 47  LEU A CB    1 
ATOM 709  C CG    . LEU D 2 35  ? 174.140 220.249 214.532 1.00 81.03  ? 47  LEU A CG    1 
ATOM 710  C CD1   . LEU D 2 35  ? 174.961 220.723 215.721 1.00 81.03  ? 47  LEU A CD1   1 
ATOM 711  C CD2   . LEU D 2 35  ? 173.237 219.098 214.934 1.00 81.03  ? 47  LEU A CD2   1 
ATOM 712  N N     . LYS D 2 36  ? 170.126 222.304 212.845 1.00 77.43  ? 48  LYS A N     1 
ATOM 713  C CA    . LYS D 2 36  ? 168.756 222.664 213.215 1.00 77.43  ? 48  LYS A CA    1 
ATOM 714  C C     . LYS D 2 36  ? 168.687 223.267 214.622 1.00 77.43  ? 48  LYS A C     1 
ATOM 715  O O     . LYS D 2 36  ? 168.081 222.709 215.540 1.00 77.43  ? 48  LYS A O     1 
ATOM 716  C CB    . LYS D 2 36  ? 167.825 221.452 213.094 1.00 77.43  ? 48  LYS A CB    1 
ATOM 717  C CG    . LYS D 2 36  ? 166.917 221.464 211.874 1.00 77.43  ? 48  LYS A CG    1 
ATOM 718  C CD    . LYS D 2 36  ? 167.603 222.092 210.674 1.00 77.43  ? 48  LYS A CD    1 
ATOM 719  C CE    . LYS D 2 36  ? 166.685 222.115 209.466 1.00 77.43  ? 48  LYS A CE    1 
ATOM 720  N NZ    . LYS D 2 36  ? 167.457 222.139 208.194 1.00 77.43  ? 48  LYS A NZ    1 
ATOM 721  N N     . LEU D 2 37  ? 169.323 224.423 214.780 1.00 79.44  ? 49  LEU A N     1 
ATOM 722  C CA    . LEU D 2 37  ? 169.192 225.225 215.988 1.00 79.44  ? 49  LEU A CA    1 
ATOM 723  C C     . LEU D 2 37  ? 168.524 226.548 215.644 1.00 79.44  ? 49  LEU A C     1 
ATOM 724  O O     . LEU D 2 37  ? 168.754 227.109 214.568 1.00 79.44  ? 49  LEU A O     1 
ATOM 725  C CB    . LEU D 2 37  ? 170.546 225.492 216.653 1.00 79.44  ? 49  LEU A CB    1 
ATOM 726  C CG    . LEU D 2 37  ? 171.598 224.386 216.731 1.00 79.44  ? 49  LEU A CG    1 
ATOM 727  C CD1   . LEU D 2 37  ? 172.490 224.413 215.506 1.00 79.44  ? 49  LEU A CD1   1 
ATOM 728  C CD2   . LEU D 2 37  ? 172.420 224.526 218.001 1.00 79.44  ? 49  LEU A CD2   1 
ATOM 729  N N     . SER D 2 38  ? 167.696 227.043 216.560 1.00 77.95  ? 50  SER A N     1 
ATOM 730  C CA    . SER D 2 38  ? 167.020 228.312 216.352 1.00 77.95  ? 50  SER A CA    1 
ATOM 731  C C     . SER D 2 38  ? 168.017 229.464 216.470 1.00 77.95  ? 50  SER A C     1 
ATOM 732  O O     . SER D 2 38  ? 169.219 229.269 216.677 1.00 77.95  ? 50  SER A O     1 
ATOM 733  C CB    . SER D 2 38  ? 165.877 228.474 217.351 1.00 77.95  ? 50  SER A CB    1 
ATOM 734  O OG    . SER D 2 38  ? 166.362 228.894 218.614 1.00 77.95  ? 50  SER A OG    1 
ATOM 735  N N     . ASP D 2 39  ? 167.505 230.688 216.330 1.00 80.16  ? 51  ASP A N     1 
ATOM 736  C CA    . ASP D 2 39  ? 168.361 231.862 216.464 1.00 80.16  ? 51  ASP A CA    1 
ATOM 737  C C     . ASP D 2 39  ? 168.942 231.960 217.868 1.00 80.16  ? 51  ASP A C     1 
ATOM 738  O O     . ASP D 2 39  ? 170.120 232.297 218.038 1.00 80.16  ? 51  ASP A O     1 
ATOM 739  C CB    . ASP D 2 39  ? 167.579 233.128 216.116 1.00 80.16  ? 51  ASP A CB    1 
ATOM 740  C CG    . ASP D 2 39  ? 168.444 234.180 215.454 1.00 80.16  ? 51  ASP A CG    1 
ATOM 741  O OD1   . ASP D 2 39  ? 169.319 233.805 214.646 1.00 80.16  ? 51  ASP A OD1   1 
ATOM 742  O OD2   . ASP D 2 39  ? 168.250 235.380 215.741 1.00 80.16  ? 51  ASP A OD2   1 
ATOM 743  N N     . TYR D 2 40  ? 168.131 231.674 218.888 1.00 78.17  ? 52  TYR A N     1 
ATOM 744  C CA    . TYR D 2 40  ? 168.632 231.693 220.258 1.00 78.17  ? 52  TYR A CA    1 
ATOM 745  C C     . TYR D 2 40  ? 169.639 230.574 220.494 1.00 78.17  ? 52  TYR A C     1 
ATOM 746  O O     . TYR D 2 40  ? 170.697 230.795 221.096 1.00 78.17  ? 52  TYR A O     1 
ATOM 747  C CB    . TYR D 2 40  ? 167.471 231.583 221.245 1.00 78.17  ? 52  TYR A CB    1 
ATOM 748  C CG    . TYR D 2 40  ? 167.808 232.088 222.628 1.00 78.17  ? 52  TYR A CG    1 
ATOM 749  C CD1   . TYR D 2 40  ? 167.968 233.444 222.872 1.00 78.17  ? 52  TYR A CD1   1 
ATOM 750  C CD2   . TYR D 2 40  ? 167.989 231.208 223.686 1.00 78.17  ? 52  TYR A CD2   1 
ATOM 751  C CE1   . TYR D 2 40  ? 168.281 233.911 224.132 1.00 78.17  ? 52  TYR A CE1   1 
ATOM 752  C CE2   . TYR D 2 40  ? 168.305 231.666 224.950 1.00 78.17  ? 52  TYR A CE2   1 
ATOM 753  C CZ    . TYR D 2 40  ? 168.451 233.018 225.167 1.00 78.17  ? 52  TYR A CZ    1 
ATOM 754  O OH    . TYR D 2 40  ? 168.765 233.478 226.425 1.00 78.17  ? 52  TYR A OH    1 
ATOM 755  N N     . GLU D 2 41  ? 169.326 229.360 220.031 1.00 78.58  ? 53  GLU A N     1 
ATOM 756  C CA    . GLU D 2 41  ? 170.236 228.237 220.236 1.00 78.58  ? 53  GLU A CA    1 
ATOM 757  C C     . GLU D 2 41  ? 171.531 228.409 219.457 1.00 78.58  ? 53  GLU A C     1 
ATOM 758  O O     . GLU D 2 41  ? 172.599 228.008 219.935 1.00 78.58  ? 53  GLU A O     1 
ATOM 759  C CB    . GLU D 2 41  ? 169.559 226.922 219.846 1.00 78.58  ? 53  GLU A CB    1 
ATOM 760  C CG    . GLU D 2 41  ? 168.537 226.417 220.852 1.00 78.58  ? 53  GLU A CG    1 
ATOM 761  C CD    . GLU D 2 41  ? 167.347 225.751 220.190 1.00 78.58  ? 53  GLU A CD    1 
ATOM 762  O OE1   . GLU D 2 41  ? 167.177 225.919 218.964 1.00 78.58  ? 53  GLU A OE1   1 
ATOM 763  O OE2   . GLU D 2 41  ? 166.585 225.056 220.894 1.00 78.58  ? 53  GLU A OE2   1 
ATOM 764  N N     . GLY D 2 42  ? 171.462 228.993 218.260 1.00 76.89  ? 54  GLY A N     1 
ATOM 765  C CA    . GLY D 2 42  ? 172.661 229.211 217.474 1.00 76.89  ? 54  GLY A CA    1 
ATOM 766  C C     . GLY D 2 42  ? 173.587 230.262 218.045 1.00 76.89  ? 54  GLY A C     1 
ATOM 767  O O     . GLY D 2 42  ? 174.777 230.270 217.712 1.00 76.89  ? 54  GLY A O     1 
ATOM 768  N N     . ARG D 2 43  ? 173.073 231.144 218.896 1.00 72.51  ? 55  ARG A N     1 
ATOM 769  C CA    . ARG D 2 43  ? 173.879 232.189 219.508 1.00 72.51  ? 55  ARG A CA    1 
ATOM 770  C C     . ARG D 2 43  ? 174.487 231.770 220.840 1.00 72.51  ? 55  ARG A C     1 
ATOM 771  O O     . ARG D 2 43  ? 175.131 232.596 221.496 1.00 72.51  ? 55  ARG A O     1 
ATOM 772  C CB    . ARG D 2 43  ? 173.047 233.461 219.694 1.00 72.51  ? 55  ARG A CB    1 
ATOM 773  C CG    . ARG D 2 43  ? 172.748 234.190 218.396 1.00 72.51  ? 55  ARG A CG    1 
ATOM 774  C CD    . ARG D 2 43  ? 171.855 235.394 218.628 1.00 72.51  ? 55  ARG A CD    1 
ATOM 775  N NE    . ARG D 2 43  ? 171.625 236.147 217.401 1.00 72.51  ? 55  ARG A NE    1 
ATOM 776  C CZ    . ARG D 2 43  ? 172.495 236.993 216.867 1.00 72.51  ? 55  ARG A CZ    1 
ATOM 777  N NH1   . ARG D 2 43  ? 173.672 237.219 217.426 1.00 72.51  ? 55  ARG A NH1   1 
ATOM 778  N NH2   . ARG D 2 43  ? 172.176 237.629 215.743 1.00 72.51  ? 55  ARG A NH2   1 
ATOM 779  N N     . LEU D 2 44  ? 174.299 230.521 221.255 1.00 74.59  ? 56  LEU A N     1 
ATOM 780  C CA    . LEU D 2 44  ? 174.905 230.046 222.491 1.00 74.59  ? 56  LEU A CA    1 
ATOM 781  C C     . LEU D 2 44  ? 176.413 229.922 222.324 1.00 74.59  ? 56  LEU A C     1 
ATOM 782  O O     . LEU D 2 44  ? 176.896 229.385 221.323 1.00 74.59  ? 56  LEU A O     1 
ATOM 783  C CB    . LEU D 2 44  ? 174.309 228.699 222.893 1.00 74.59  ? 56  LEU A CB    1 
ATOM 784  C CG    . LEU D 2 44  ? 173.258 228.727 224.001 1.00 74.59  ? 56  LEU A CG    1 
ATOM 785  C CD1   . LEU D 2 44  ? 172.509 227.407 224.049 1.00 74.59  ? 56  LEU A CD1   1 
ATOM 786  C CD2   . LEU D 2 44  ? 173.904 229.030 225.342 1.00 74.59  ? 56  LEU A CD2   1 
ATOM 787  N N     . ILE D 2 45  ? 177.160 230.423 223.310 1.00 74.18  ? 57  ILE A N     1 
ATOM 788  C CA    . ILE D 2 45  ? 178.612 230.311 223.251 1.00 74.18  ? 57  ILE A CA    1 
ATOM 789  C C     . ILE D 2 45  ? 179.046 228.864 223.452 1.00 74.18  ? 57  ILE A C     1 
ATOM 790  O O     . ILE D 2 45  ? 180.069 228.435 222.905 1.00 74.18  ? 57  ILE A O     1 
ATOM 791  C CB    . ILE D 2 45  ? 179.272 231.257 224.273 1.00 74.18  ? 57  ILE A CB    1 
ATOM 792  C CG1   . ILE D 2 45  ? 180.787 231.295 224.068 1.00 74.18  ? 57  ILE A CG1   1 
ATOM 793  C CG2   . ILE D 2 45  ? 178.938 230.838 225.694 1.00 74.18  ? 57  ILE A CG2   1 
ATOM 794  C CD1   . ILE D 2 45  ? 181.474 232.413 224.816 1.00 74.18  ? 57  ILE A CD1   1 
ATOM 795  N N     . GLN D 2 46  ? 178.285 228.089 224.229 1.00 74.82  ? 58  GLN A N     1 
ATOM 796  C CA    . GLN D 2 46  ? 178.610 226.678 224.405 1.00 74.82  ? 58  GLN A CA    1 
ATOM 797  C C     . GLN D 2 46  ? 178.478 225.911 223.095 1.00 74.82  ? 58  GLN A C     1 
ATOM 798  O O     . GLN D 2 46  ? 179.327 225.072 222.772 1.00 74.82  ? 58  GLN A O     1 
ATOM 799  C CB    . GLN D 2 46  ? 177.717 226.064 225.482 1.00 74.82  ? 58  GLN A CB    1 
ATOM 800  C CG    . GLN D 2 46  ? 178.255 226.214 226.896 1.00 74.82  ? 58  GLN A CG    1 
ATOM 801  C CD    . GLN D 2 46  ? 177.887 227.543 227.522 1.00 74.82  ? 58  GLN A CD    1 
ATOM 802  O OE1   . GLN D 2 46  ? 177.093 228.304 226.970 1.00 74.82  ? 58  GLN A OE1   1 
ATOM 803  N NE2   . GLN D 2 46  ? 178.459 227.828 228.685 1.00 74.82  ? 58  GLN A NE2   1 
ATOM 804  N N     . ASN D 2 47  ? 177.423 226.186 222.324 1.00 74.52  ? 59  ASN A N     1 
ATOM 805  C CA    . ASN D 2 47  ? 177.259 225.527 221.032 1.00 74.52  ? 59  ASN A CA    1 
ATOM 806  C C     . ASN D 2 47  ? 178.362 225.926 220.059 1.00 74.52  ? 59  ASN A C     1 
ATOM 807  O O     . ASN D 2 47  ? 178.872 225.084 219.309 1.00 74.52  ? 59  ASN A O     1 
ATOM 808  C CB    . ASN D 2 47  ? 175.884 225.849 220.449 1.00 74.52  ? 59  ASN A CB    1 
ATOM 809  C CG    . ASN D 2 47  ? 174.767 225.109 221.155 1.00 74.52  ? 59  ASN A CG    1 
ATOM 810  O OD1   . ASN D 2 47  ? 174.988 224.061 221.762 1.00 74.52  ? 59  ASN A OD1   1 
ATOM 811  N ND2   . ASN D 2 47  ? 173.558 225.651 221.079 1.00 74.52  ? 59  ASN A ND2   1 
ATOM 812  N N     . SER D 2 48  ? 178.740 227.207 220.049 1.00 72.98  ? 60  SER A N     1 
ATOM 813  C CA    . SER D 2 48  ? 179.829 227.643 219.182 1.00 72.98  ? 60  SER A CA    1 
ATOM 814  C C     . SER D 2 48  ? 181.142 226.984 219.581 1.00 72.98  ? 60  SER A C     1 
ATOM 815  O O     . SER D 2 48  ? 181.936 226.590 218.719 1.00 72.98  ? 60  SER A O     1 
ATOM 816  C CB    . SER D 2 48  ? 179.958 229.166 219.221 1.00 72.98  ? 60  SER A CB    1 
ATOM 817  O OG    . SER D 2 48  ? 180.339 229.612 220.509 1.00 72.98  ? 60  SER A OG    1 
ATOM 818  N N     . LEU D 2 49  ? 181.387 226.850 220.886 1.00 73.71  ? 61  LEU A N     1 
ATOM 819  C CA    . LEU D 2 49  ? 182.590 226.171 221.353 1.00 73.71  ? 61  LEU A CA    1 
ATOM 820  C C     . LEU D 2 49  ? 182.572 224.699 220.954 1.00 73.71  ? 61  LEU A C     1 
ATOM 821  O O     . LEU D 2 49  ? 183.605 224.138 220.569 1.00 73.71  ? 61  LEU A O     1 
ATOM 822  C CB    . LEU D 2 49  ? 182.712 226.334 222.869 1.00 73.71  ? 61  LEU A CB    1 
ATOM 823  C CG    . LEU D 2 49  ? 184.086 226.368 223.545 1.00 73.71  ? 61  LEU A CG    1 
ATOM 824  C CD1   . LEU D 2 49  ? 183.922 226.690 225.021 1.00 73.71  ? 61  LEU A CD1   1 
ATOM 825  C CD2   . LEU D 2 49  ? 184.848 225.069 223.379 1.00 73.71  ? 61  LEU A CD2   1 
ATOM 826  N N     . THR D 2 50  ? 181.403 224.060 221.034 1.00 75.10  ? 62  THR A N     1 
ATOM 827  C CA    . THR D 2 50  ? 181.281 222.671 220.603 1.00 75.10  ? 62  THR A CA    1 
ATOM 828  C C     . THR D 2 50  ? 181.576 222.528 219.115 1.00 75.10  ? 62  THR A C     1 
ATOM 829  O O     . THR D 2 50  ? 182.270 221.594 218.699 1.00 75.10  ? 62  THR A O     1 
ATOM 830  C CB    . THR D 2 50  ? 179.883 222.145 220.927 1.00 75.10  ? 62  THR A CB    1 
ATOM 831  O OG1   . THR D 2 50  ? 179.765 221.937 222.340 1.00 75.10  ? 62  THR A OG1   1 
ATOM 832  C CG2   . THR D 2 50  ? 179.622 220.832 220.205 1.00 75.10  ? 62  THR A CG2   1 
ATOM 833  N N     . ILE D 2 51  ? 181.064 223.450 218.298 1.00 74.71  ? 63  ILE A N     1 
ATOM 834  C CA    . ILE D 2 51  ? 181.339 223.409 216.862 1.00 74.71  ? 63  ILE A CA    1 
ATOM 835  C C     . ILE D 2 51  ? 182.824 223.630 216.593 1.00 74.71  ? 63  ILE A C     1 
ATOM 836  O O     . ILE D 2 51  ? 183.422 222.978 215.726 1.00 74.71  ? 63  ILE A O     1 
ATOM 837  C CB    . ILE D 2 51  ? 180.464 224.439 216.124 1.00 74.71  ? 63  ILE A CB    1 
ATOM 838  C CG1   . ILE D 2 51  ? 178.992 224.029 216.200 1.00 74.71  ? 63  ILE A CG1   1 
ATOM 839  C CG2   . ILE D 2 51  ? 180.907 224.587 214.677 1.00 74.71  ? 63  ILE A CG2   1 
ATOM 840  C CD1   . ILE D 2 51  ? 178.082 224.835 215.303 1.00 74.71  ? 63  ILE A CD1   1 
ATOM 841  N N     . GLU D 2 52  ? 183.444 224.556 217.327 1.00 75.37  ? 64  GLU A N     1 
ATOM 842  C CA    . GLU D 2 52  ? 184.874 224.789 217.157 1.00 75.37  ? 64  GLU A CA    1 
ATOM 843  C C     . GLU D 2 52  ? 185.681 223.545 217.509 1.00 75.37  ? 64  GLU A C     1 
ATOM 844  O O     . GLU D 2 52  ? 186.640 223.200 216.808 1.00 75.37  ? 64  GLU A O     1 
ATOM 845  C CB    . GLU D 2 52  ? 185.317 225.982 218.002 1.00 75.37  ? 64  GLU A CB    1 
ATOM 846  C CG    . GLU D 2 52  ? 184.824 227.320 217.483 1.00 75.37  ? 64  GLU A CG    1 
ATOM 847  C CD    . GLU D 2 52  ? 184.769 228.380 218.563 1.00 75.37  ? 64  GLU A CD    1 
ATOM 848  O OE1   . GLU D 2 52  ? 184.816 228.016 219.757 1.00 75.37  ? 64  GLU A OE1   1 
ATOM 849  O OE2   . GLU D 2 52  ? 184.678 229.577 218.220 1.00 75.37  ? 64  GLU A OE2   1 
ATOM 850  N N     . ARG D 2 53  ? 185.309 222.859 218.593 1.00 75.29  ? 65  ARG A N     1 
ATOM 851  C CA    . ARG D 2 53  ? 185.976 221.604 218.927 1.00 75.29  ? 65  ARG A CA    1 
ATOM 852  C C     . ARG D 2 53  ? 185.724 220.547 217.859 1.00 75.29  ? 65  ARG A C     1 
ATOM 853  O O     . ARG D 2 53  ? 186.606 219.734 217.567 1.00 75.29  ? 65  ARG A O     1 
ATOM 854  C CB    . ARG D 2 53  ? 185.525 221.103 220.298 1.00 75.29  ? 65  ARG A CB    1 
ATOM 855  C CG    . ARG D 2 53  ? 185.855 222.042 221.440 1.00 75.29  ? 65  ARG A CG    1 
ATOM 856  C CD    . ARG D 2 53  ? 185.196 221.587 222.734 1.00 75.29  ? 65  ARG A CD    1 
ATOM 857  N NE    . ARG D 2 53  ? 185.984 220.585 223.444 1.00 75.29  ? 65  ARG A NE    1 
ATOM 858  C CZ    . ARG D 2 53  ? 187.182 220.796 223.974 1.00 75.29  ? 65  ARG A CZ    1 
ATOM 859  N NH1   . ARG D 2 53  ? 187.761 221.985 223.928 1.00 75.29  ? 65  ARG A NH1   1 
ATOM 860  N NH2   . ARG D 2 53  ? 187.810 219.792 224.577 1.00 75.29  ? 65  ARG A NH2   1 
ATOM 861  N N     . MET D 2 54  ? 184.524 220.542 217.270 1.00 80.41  ? 66  MET A N     1 
ATOM 862  C CA    . MET D 2 54  ? 184.244 219.678 216.127 1.00 80.41  ? 66  MET A CA    1 
ATOM 863  C C     . MET D 2 54  ? 185.287 219.872 215.037 1.00 80.41  ? 66  MET A C     1 
ATOM 864  O O     . MET D 2 54  ? 185.921 218.913 214.578 1.00 80.41  ? 66  MET A O     1 
ATOM 865  C CB    . MET D 2 54  ? 182.856 219.995 215.564 1.00 80.41  ? 66  MET A CB    1 
ATOM 866  C CG    . MET D 2 54  ? 181.693 219.167 216.061 1.00 80.41  ? 66  MET A CG    1 
ATOM 867  S SD    . MET D 2 54  ? 181.808 217.436 215.597 1.00 80.41  ? 66  MET A SD    1 
ATOM 868  C CE    . MET D 2 54  ? 181.033 216.691 217.017 1.00 80.41  ? 66  MET A CE    1 
ATOM 869  N N     . VAL D 2 55  ? 185.489 221.125 214.629 1.00 77.10  ? 67  VAL A N     1 
ATOM 870  C CA    . VAL D 2 55  ? 186.422 221.401 213.539 1.00 77.10  ? 67  VAL A CA    1 
ATOM 871  C C     . VAL D 2 55  ? 187.844 221.036 213.942 1.00 77.10  ? 67  VAL A C     1 
ATOM 872  O O     . VAL D 2 55  ? 188.589 220.433 213.160 1.00 77.10  ? 67  VAL A O     1 
ATOM 873  C CB    . VAL D 2 55  ? 186.333 222.872 213.102 1.00 77.10  ? 67  VAL A CB    1 
ATOM 874  C CG1   . VAL D 2 55  ? 186.894 223.035 211.701 1.00 77.10  ? 67  VAL A CG1   1 
ATOM 875  C CG2   . VAL D 2 55  ? 184.919 223.347 213.162 1.00 77.10  ? 67  VAL A CG2   1 
ATOM 876  N N     . LEU D 2 56  ? 188.248 221.404 215.160 1.00 75.87  ? 68  LEU A N     1 
ATOM 877  C CA    . LEU D 2 56  ? 189.625 221.167 215.579 1.00 75.87  ? 68  LEU A CA    1 
ATOM 878  C C     . LEU D 2 56  ? 189.933 219.678 215.672 1.00 75.87  ? 68  LEU A C     1 
ATOM 879  O O     . LEU D 2 56  ? 191.011 219.234 215.260 1.00 75.87  ? 68  LEU A O     1 
ATOM 880  C CB    . LEU D 2 56  ? 189.896 221.862 216.912 1.00 75.87  ? 68  LEU A CB    1 
ATOM 881  C CG    . LEU D 2 56  ? 189.831 223.389 216.845 1.00 75.87  ? 68  LEU A CG    1 
ATOM 882  C CD1   . LEU D 2 56  ? 190.304 224.014 218.148 1.00 75.87  ? 68  LEU A CD1   1 
ATOM 883  C CD2   . LEU D 2 56  ? 190.632 223.907 215.662 1.00 75.87  ? 68  LEU A CD2   1 
ATOM 884  N N     . SER D 2 57  ? 189.000 218.887 216.207 1.00 82.89  ? 69  SER A N     1 
ATOM 885  C CA    . SER D 2 57  ? 189.215 217.449 216.289 1.00 82.89  ? 69  SER A CA    1 
ATOM 886  C C     . SER D 2 57  ? 189.142 216.792 214.919 1.00 82.89  ? 69  SER A C     1 
ATOM 887  O O     . SER D 2 57  ? 189.811 215.780 214.683 1.00 82.89  ? 69  SER A O     1 
ATOM 888  C CB    . SER D 2 57  ? 188.195 216.817 217.235 1.00 82.89  ? 69  SER A CB    1 
ATOM 889  O OG    . SER D 2 57  ? 188.365 215.412 217.302 1.00 82.89  ? 69  SER A OG    1 
ATOM 890  N N     . ALA D 2 58  ? 188.334 217.342 214.010 1.00 82.76  ? 70  ALA A N     1 
ATOM 891  C CA    . ALA D 2 58  ? 188.243 216.771 212.670 1.00 82.76  ? 70  ALA A CA    1 
ATOM 892  C C     . ALA D 2 58  ? 189.563 216.896 211.918 1.00 82.76  ? 70  ALA A C     1 
ATOM 893  O O     . ALA D 2 58  ? 189.968 215.968 211.209 1.00 82.76  ? 70  ALA A O     1 
ATOM 894  C CB    . ALA D 2 58  ? 187.115 217.444 211.890 1.00 82.76  ? 70  ALA A CB    1 
ATOM 895  N N     . PHE D 2 59  ? 190.249 218.027 212.060 1.00 78.31  ? 71  PHE A N     1 
ATOM 896  C CA    . PHE D 2 59  ? 191.441 218.318 211.275 1.00 78.31  ? 71  PHE A CA    1 
ATOM 897  C C     . PHE D 2 59  ? 192.742 217.995 211.999 1.00 78.31  ? 71  PHE A C     1 
ATOM 898  O O     . PHE D 2 59  ? 193.816 218.284 211.463 1.00 78.31  ? 71  PHE A O     1 
ATOM 899  C CB    . PHE D 2 59  ? 191.442 219.788 210.850 1.00 78.31  ? 71  PHE A CB    1 
ATOM 900  C CG    . PHE D 2 59  ? 190.590 220.069 209.648 1.00 78.31  ? 71  PHE A CG    1 
ATOM 901  C CD1   . PHE D 2 59  ? 189.253 220.395 209.793 1.00 78.31  ? 71  PHE A CD1   1 
ATOM 902  C CD2   . PHE D 2 59  ? 191.123 220.000 208.374 1.00 78.31  ? 71  PHE A CD2   1 
ATOM 903  C CE1   . PHE D 2 59  ? 188.465 220.651 208.690 1.00 78.31  ? 71  PHE A CE1   1 
ATOM 904  C CE2   . PHE D 2 59  ? 190.340 220.255 207.267 1.00 78.31  ? 71  PHE A CE2   1 
ATOM 905  C CZ    . PHE D 2 59  ? 189.009 220.581 207.426 1.00 78.31  ? 71  PHE A CZ    1 
ATOM 906  N N     . ASP D 2 60  ? 192.682 217.410 213.192 1.00 86.01  ? 72  ASP A N     1 
ATOM 907  C CA    . ASP D 2 60  ? 193.892 217.033 213.919 1.00 86.01  ? 72  ASP A CA    1 
ATOM 908  C C     . ASP D 2 60  ? 194.445 215.760 213.292 1.00 86.01  ? 72  ASP A C     1 
ATOM 909  O O     . ASP D 2 60  ? 194.015 214.653 213.622 1.00 86.01  ? 72  ASP A O     1 
ATOM 910  C CB    . ASP D 2 60  ? 193.594 216.843 215.401 1.00 86.01  ? 72  ASP A CB    1 
ATOM 911  C CG    . ASP D 2 60  ? 194.827 217.005 216.267 1.00 86.01  ? 72  ASP A CG    1 
ATOM 912  O OD1   . ASP D 2 60  ? 195.945 217.039 215.710 1.00 86.01  ? 72  ASP A OD1   1 
ATOM 913  O OD2   . ASP D 2 60  ? 194.679 217.105 217.502 1.00 86.01  ? 72  ASP A OD2   1 
ATOM 914  N N     . GLU D 2 61  ? 195.410 215.919 212.383 1.00 94.43  ? 73  GLU A N     1 
ATOM 915  C CA    . GLU D 2 61  ? 195.903 214.784 211.609 1.00 94.43  ? 73  GLU A CA    1 
ATOM 916  C C     . GLU D 2 61  ? 196.588 213.755 212.501 1.00 94.43  ? 73  GLU A C     1 
ATOM 917  O O     . GLU D 2 61  ? 196.337 212.549 212.380 1.00 94.43  ? 73  GLU A O     1 
ATOM 918  C CB    . GLU D 2 61  ? 196.858 215.274 210.517 1.00 94.43  ? 73  GLU A CB    1 
ATOM 919  C CG    . GLU D 2 61  ? 196.433 215.020 209.055 1.00 94.43  ? 73  GLU A CG    1 
ATOM 920  C CD    . GLU D 2 61  ? 196.026 213.582 208.716 1.00 94.43  ? 73  GLU A CD    1 
ATOM 921  O OE1   . GLU D 2 61  ? 196.028 212.688 209.588 1.00 94.43  ? 73  GLU A OE1   1 
ATOM 922  O OE2   . GLU D 2 61  ? 195.692 213.345 207.535 1.00 94.43  ? 73  GLU A OE2   1 
ATOM 923  N N     . ARG D 2 62  ? 197.463 214.210 213.401 1.00 95.06  ? 74  ARG A N     1 
ATOM 924  C CA    . ARG D 2 62  ? 198.178 213.276 214.265 1.00 95.06  ? 74  ARG A CA    1 
ATOM 925  C C     . ARG D 2 62  ? 197.213 212.551 215.194 1.00 95.06  ? 74  ARG A C     1 
ATOM 926  O O     . ARG D 2 62  ? 197.327 211.336 215.395 1.00 95.06  ? 74  ARG A O     1 
ATOM 927  C CB    . ARG D 2 62  ? 199.277 214.021 215.039 1.00 95.06  ? 74  ARG A CB    1 
ATOM 928  C CG    . ARG D 2 62  ? 200.407 214.694 214.229 1.00 95.06  ? 74  ARG A CG    1 
ATOM 929  C CD    . ARG D 2 62  ? 201.350 213.724 213.512 1.00 95.06  ? 74  ARG A CD    1 
ATOM 930  N NE    . ARG D 2 62  ? 202.392 214.422 212.767 1.00 95.06  ? 74  ARG A NE    1 
ATOM 931  C CZ    . ARG D 2 62  ? 203.535 214.842 213.291 1.00 95.06  ? 74  ARG A CZ    1 
ATOM 932  N NH1   . ARG D 2 62  ? 203.819 214.655 214.570 1.00 95.06  ? 74  ARG A NH1   1 
ATOM 933  N NH2   . ARG D 2 62  ? 204.415 215.466 212.514 1.00 95.06  ? 74  ARG A NH2   1 
ATOM 934  N N     . ARG D 2 63  ? 196.251 213.278 215.767 1.00 92.96  ? 75  ARG A N     1 
ATOM 935  C CA    . ARG D 2 63  ? 195.263 212.645 216.634 1.00 92.96  ? 75  ARG A CA    1 
ATOM 936  C C     . ARG D 2 63  ? 194.396 211.669 215.850 1.00 92.96  ? 75  ARG A C     1 
ATOM 937  O O     . ARG D 2 63  ? 194.059 210.586 216.342 1.00 92.96  ? 75  ARG A O     1 
ATOM 938  C CB    . ARG D 2 63  ? 194.402 213.707 217.316 1.00 92.96  ? 75  ARG A CB    1 
ATOM 939  C CG    . ARG D 2 63  ? 194.894 214.105 218.699 1.00 92.96  ? 75  ARG A CG    1 
ATOM 940  C CD    . ARG D 2 63  ? 194.460 213.102 219.758 1.00 92.96  ? 75  ARG A CD    1 
ATOM 941  N NE    . ARG D 2 63  ? 193.010 213.010 219.871 1.00 92.96  ? 75  ARG A NE    1 
ATOM 942  C CZ    . ARG D 2 63  ? 192.369 212.022 220.480 1.00 92.96  ? 75  ARG A CZ    1 
ATOM 943  N NH1   . ARG D 2 63  ? 193.021 211.021 221.047 1.00 92.96  ? 75  ARG A NH1   1 
ATOM 944  N NH2   . ARG D 2 63  ? 191.040 212.040 220.522 1.00 92.96  ? 75  ARG A NH2   1 
ATOM 945  N N     . ASN D 2 64  ? 194.021 212.039 214.622 1.00 93.13  ? 76  ASN A N     1 
ATOM 946  C CA    . ASN D 2 64  ? 193.228 211.135 213.796 1.00 93.13  ? 76  ASN A CA    1 
ATOM 947  C C     . ASN D 2 64  ? 193.985 209.847 213.507 1.00 93.13  ? 76  ASN A C     1 
ATOM 948  O O     . ASN D 2 64  ? 193.420 208.754 213.611 1.00 93.13  ? 76  ASN A O     1 
ATOM 949  C CB    . ASN D 2 64  ? 192.823 211.823 212.494 1.00 93.13  ? 76  ASN A CB    1 
ATOM 950  C CG    . ASN D 2 64  ? 191.758 212.880 212.700 1.00 93.13  ? 76  ASN A CG    1 
ATOM 951  O OD1   . ASN D 2 64  ? 191.240 213.046 213.804 1.00 93.13  ? 76  ASN A OD1   1 
ATOM 952  N ND2   . ASN D 2 64  ? 191.426 213.601 211.637 1.00 93.13  ? 76  ASN A ND2   1 
ATOM 953  N N     . LYS D 2 65  ? 195.270 209.952 213.159 1.00 97.47  ? 77  LYS A N     1 
ATOM 954  C CA    . LYS D 2 65  ? 196.059 208.753 212.891 1.00 97.47  ? 77  LYS A CA    1 
ATOM 955  C C     . LYS D 2 65  ? 196.234 207.914 214.152 1.00 97.47  ? 77  LYS A C     1 
ATOM 956  O O     . LYS D 2 65  ? 196.164 206.678 214.103 1.00 97.47  ? 77  LYS A O     1 
ATOM 957  C CB    . LYS D 2 65  ? 197.420 209.141 212.308 1.00 97.47  ? 77  LYS A CB    1 
ATOM 958  C CG    . LYS D 2 65  ? 197.523 209.053 210.780 1.00 97.47  ? 77  LYS A CG    1 
ATOM 959  C CD    . LYS D 2 65  ? 197.112 207.700 210.181 1.00 97.47  ? 77  LYS A CD    1 
ATOM 960  C CE    . LYS D 2 65  ? 197.678 206.498 210.937 1.00 97.47  ? 77  LYS A CE    1 
ATOM 961  N NZ    . LYS D 2 65  ? 199.140 206.627 211.193 1.00 97.47  ? 77  LYS A NZ    1 
ATOM 962  N N     . TYR D 2 66  ? 196.459 208.573 215.293 1.00 96.75  ? 78  TYR A N     1 
ATOM 963  C CA    . TYR D 2 66  ? 196.585 207.865 216.562 1.00 96.75  ? 78  TYR A CA    1 
ATOM 964  C C     . TYR D 2 66  ? 195.319 207.070 216.857 1.00 96.75  ? 78  TYR A C     1 
ATOM 965  O O     . TYR D 2 66  ? 195.385 205.883 217.198 1.00 96.75  ? 78  TYR A O     1 
ATOM 966  C CB    . TYR D 2 66  ? 196.876 208.883 217.672 1.00 96.75  ? 78  TYR A CB    1 
ATOM 967  C CG    . TYR D 2 66  ? 197.167 208.356 219.072 1.00 96.75  ? 78  TYR A CG    1 
ATOM 968  C CD1   . TYR D 2 66  ? 197.039 207.011 219.396 1.00 96.75  ? 78  TYR A CD1   1 
ATOM 969  C CD2   . TYR D 2 66  ? 197.607 209.222 220.066 1.00 96.75  ? 78  TYR A CD2   1 
ATOM 970  C CE1   . TYR D 2 66  ? 197.310 206.553 220.670 1.00 96.75  ? 78  TYR A CE1   1 
ATOM 971  C CE2   . TYR D 2 66  ? 197.882 208.771 221.341 1.00 96.75  ? 78  TYR A CE2   1 
ATOM 972  C CZ    . TYR D 2 66  ? 197.734 207.436 221.637 1.00 96.75  ? 78  TYR A CZ    1 
ATOM 973  O OH    . TYR D 2 66  ? 198.011 206.982 222.906 1.00 96.75  ? 78  TYR A OH    1 
ATOM 974  N N     . LEU D 2 67  ? 194.155 207.702 216.703 1.00 97.42  ? 79  LEU A N     1 
ATOM 975  C CA    . LEU D 2 67  ? 192.899 207.005 216.949 1.00 97.42  ? 79  LEU A CA    1 
ATOM 976  C C     . LEU D 2 67  ? 192.654 205.899 215.928 1.00 97.42  ? 79  LEU A C     1 
ATOM 977  O O     . LEU D 2 67  ? 192.083 204.858 216.273 1.00 97.42  ? 79  LEU A O     1 
ATOM 978  C CB    . LEU D 2 67  ? 191.742 208.004 216.955 1.00 97.42  ? 79  LEU A CB    1 
ATOM 979  C CG    . LEU D 2 67  ? 191.807 209.110 218.009 1.00 97.42  ? 79  LEU A CG    1 
ATOM 980  C CD1   . LEU D 2 67  ? 190.968 210.304 217.587 1.00 97.42  ? 79  LEU A CD1   1 
ATOM 981  C CD2   . LEU D 2 67  ? 191.351 208.584 219.359 1.00 97.42  ? 79  LEU A CD2   1 
ATOM 982  N N     . GLU D 2 68  ? 193.067 206.103 214.675 1.00 100.74 ? 80  GLU A N     1 
ATOM 983  C CA    . GLU D 2 68  ? 192.912 205.059 213.666 1.00 100.74 ? 80  GLU A CA    1 
ATOM 984  C C     . GLU D 2 68  ? 193.717 203.818 214.023 1.00 100.74 ? 80  GLU A C     1 
ATOM 985  O O     . GLU D 2 68  ? 193.207 202.694 213.957 1.00 100.74 ? 80  GLU A O     1 
ATOM 986  C CB    . GLU D 2 68  ? 193.333 205.578 212.288 1.00 100.74 ? 80  GLU A CB    1 
ATOM 987  C CG    . GLU D 2 68  ? 192.442 206.638 211.624 1.00 100.74 ? 80  GLU A CG    1 
ATOM 988  C CD    . GLU D 2 68  ? 190.946 206.492 211.887 1.00 100.74 ? 80  GLU A CD    1 
ATOM 989  O OE1   . GLU D 2 68  ? 190.448 205.360 212.070 1.00 100.74 ? 80  GLU A OE1   1 
ATOM 990  O OE2   . GLU D 2 68  ? 190.257 207.533 211.901 1.00 100.74 ? 80  GLU A OE2   1 
ATOM 991  N N     . GLU D 2 69  ? 194.982 203.998 214.404 1.00 102.16 ? 81  GLU A N     1 
ATOM 992  C CA    . GLU D 2 69  ? 195.873 202.848 214.478 1.00 102.16 ? 81  GLU A CA    1 
ATOM 993  C C     . GLU D 2 69  ? 196.014 202.313 215.904 1.00 102.16 ? 81  GLU A C     1 
ATOM 994  O O     . GLU D 2 69  ? 196.386 201.147 216.080 1.00 102.16 ? 81  GLU A O     1 
ATOM 995  C CB    . GLU D 2 69  ? 197.212 203.228 213.819 1.00 102.16 ? 81  GLU A CB    1 
ATOM 996  C CG    . GLU D 2 69  ? 197.265 203.540 212.330 1.00 102.16 ? 81  GLU A CG    1 
ATOM 997  C CD    . GLU D 2 69  ? 196.782 202.433 211.438 1.00 102.16 ? 81  GLU A CD    1 
ATOM 998  O OE1   . GLU D 2 69  ? 197.105 201.274 211.756 1.00 102.16 ? 81  GLU A OE1   1 
ATOM 999  O OE2   . GLU D 2 69  ? 196.092 202.716 210.437 1.00 102.16 ? 81  GLU A OE2   1 
ATOM 1000 N N     . HIS D 2 70  ? 195.706 203.126 216.915 1.00 100.32 ? 82  HIS A N     1 
ATOM 1001 C CA    . HIS D 2 70  ? 195.213 202.641 218.210 1.00 100.32 ? 82  HIS A CA    1 
ATOM 1002 C C     . HIS D 2 70  ? 193.746 203.017 218.355 1.00 100.32 ? 82  HIS A C     1 
ATOM 1003 O O     . HIS D 2 70  ? 193.426 204.184 218.644 1.00 100.32 ? 82  HIS A O     1 
ATOM 1004 C CB    . HIS D 2 70  ? 196.002 203.187 219.402 1.00 100.32 ? 82  HIS A CB    1 
ATOM 1005 C CG    . HIS D 2 70  ? 197.479 202.952 219.344 1.00 100.32 ? 82  HIS A CG    1 
ATOM 1006 N ND1   . HIS D 2 70  ? 198.396 203.800 219.925 1.00 100.32 ? 82  HIS A ND1   1 
ATOM 1007 C CD2   . HIS D 2 70  ? 198.199 201.993 218.715 1.00 100.32 ? 82  HIS A CD2   1 
ATOM 1008 C CE1   . HIS D 2 70  ? 199.617 203.364 219.670 1.00 100.32 ? 82  HIS A CE1   1 
ATOM 1009 N NE2   . HIS D 2 70  ? 199.525 202.262 218.950 1.00 100.32 ? 82  HIS A NE2   1 
ATOM 1010 N N     . PRO D 2 71  ? 192.821 202.075 218.168 1.00 98.05  ? 83  PRO A N     1 
ATOM 1011 C CA    . PRO D 2 71  ? 191.404 202.379 218.397 1.00 98.05  ? 83  PRO A CA    1 
ATOM 1012 C C     . PRO D 2 71  ? 191.120 202.638 219.869 1.00 98.05  ? 83  PRO A C     1 
ATOM 1013 O O     . PRO D 2 71  ? 191.799 202.120 220.758 1.00 98.05  ? 83  PRO A O     1 
ATOM 1014 C CB    . PRO D 2 71  ? 190.684 201.116 217.905 1.00 98.05  ? 83  PRO A CB    1 
ATOM 1015 C CG    . PRO D 2 71  ? 191.682 200.404 217.043 1.00 98.05  ? 83  PRO A CG    1 
ATOM 1016 C CD    . PRO D 2 71  ? 193.018 200.718 217.635 1.00 98.05  ? 83  PRO A CD    1 
ATOM 1017 N N     . SER D 2 72  ? 190.096 203.451 220.120 1.00 100.40 ? 84  SER A N     1 
ATOM 1018 C CA    . SER D 2 72  ? 189.689 203.768 221.480 1.00 100.40 ? 84  SER A CA    1 
ATOM 1019 C C     . SER D 2 72  ? 188.771 202.676 222.028 1.00 100.40 ? 84  SER A C     1 
ATOM 1020 O O     . SER D 2 72  ? 188.464 201.685 221.359 1.00 100.40 ? 84  SER A O     1 
ATOM 1021 C CB    . SER D 2 72  ? 189.007 205.132 221.527 1.00 100.40 ? 84  SER A CB    1 
ATOM 1022 O OG    . SER D 2 72  ? 188.694 205.497 222.860 1.00 100.40 ? 84  SER A OG    1 
ATOM 1023 N N     . ALA D 2 73  ? 188.325 202.861 223.269 1.00 99.49  ? 85  ALA A N     1 
ATOM 1024 C CA    . ALA D 2 73  ? 187.456 201.897 223.943 1.00 99.49  ? 85  ALA A CA    1 
ATOM 1025 C C     . ALA D 2 73  ? 186.009 202.338 223.766 1.00 99.49  ? 85  ALA A C     1 
ATOM 1026 O O     . ALA D 2 73  ? 185.544 203.271 224.426 1.00 99.49  ? 85  ALA A O     1 
ATOM 1027 C CB    . ALA D 2 73  ? 187.826 201.778 225.417 1.00 99.49  ? 85  ALA A CB    1 
ATOM 1028 N N     . GLY D 2 74  ? 185.292 201.668 222.867 1.00 97.73  ? 86  GLY A N     1 
ATOM 1029 C CA    . GLY D 2 74  ? 183.899 201.972 222.623 1.00 97.73  ? 86  GLY A CA    1 
ATOM 1030 C C     . GLY D 2 74  ? 183.639 203.267 221.890 1.00 97.73  ? 86  GLY A C     1 
ATOM 1031 O O     . GLY D 2 74  ? 182.472 203.615 221.680 1.00 97.73  ? 86  GLY A O     1 
ATOM 1032 N N     . LYS D 2 75  ? 184.683 203.988 221.490 1.00 97.39  ? 87  LYS A N     1 
ATOM 1033 C CA    . LYS D 2 75  ? 184.557 205.251 220.772 1.00 97.39  ? 87  LYS A CA    1 
ATOM 1034 C C     . LYS D 2 75  ? 185.288 205.092 219.446 1.00 97.39  ? 87  LYS A C     1 
ATOM 1035 O O     . LYS D 2 75  ? 186.513 204.935 219.427 1.00 97.39  ? 87  LYS A O     1 
ATOM 1036 C CB    . LYS D 2 75  ? 185.145 206.404 221.586 1.00 97.39  ? 87  LYS A CB    1 
ATOM 1037 C CG    . LYS D 2 75  ? 184.384 206.735 222.865 1.00 97.39  ? 87  LYS A CG    1 
ATOM 1038 C CD    . LYS D 2 75  ? 185.022 207.869 223.647 1.00 97.39  ? 87  LYS A CD    1 
ATOM 1039 C CE    . LYS D 2 75  ? 184.228 208.189 224.898 1.00 97.39  ? 87  LYS A CE    1 
ATOM 1040 N NZ    . LYS D 2 75  ? 184.863 209.285 225.681 1.00 97.39  ? 87  LYS A NZ    1 
ATOM 1041 N N     . ASP D 2 76  ? 184.546 205.123 218.342 1.00 94.19  ? 88  ASP A N     1 
ATOM 1042 C CA    . ASP D 2 76  ? 185.175 204.914 217.050 1.00 94.19  ? 88  ASP A CA    1 
ATOM 1043 C C     . ASP D 2 76  ? 186.082 206.093 216.693 1.00 94.19  ? 88  ASP A C     1 
ATOM 1044 O O     . ASP D 2 76  ? 185.826 207.232 217.092 1.00 94.19  ? 88  ASP A O     1 
ATOM 1045 C CB    . ASP D 2 76  ? 184.127 204.688 215.958 1.00 94.19  ? 88  ASP A CB    1 
ATOM 1046 C CG    . ASP D 2 76  ? 183.197 205.876 215.758 1.00 94.19  ? 88  ASP A CG    1 
ATOM 1047 O OD1   . ASP D 2 76  ? 183.284 206.864 216.510 1.00 94.19  ? 88  ASP A OD1   1 
ATOM 1048 O OD2   . ASP D 2 76  ? 182.366 205.817 214.828 1.00 94.19  ? 88  ASP A OD2   1 
ATOM 1049 N N     . PRO D 2 77  ? 187.170 205.838 215.968 1.00 93.58  ? 89  PRO A N     1 
ATOM 1050 C CA    . PRO D 2 77  ? 188.052 206.921 215.523 1.00 93.58  ? 89  PRO A CA    1 
ATOM 1051 C C     . PRO D 2 77  ? 187.557 207.669 214.296 1.00 93.58  ? 89  PRO A C     1 
ATOM 1052 O O     . PRO D 2 77  ? 188.308 208.476 213.743 1.00 93.58  ? 89  PRO A O     1 
ATOM 1053 C CB    . PRO D 2 77  ? 189.355 206.176 215.205 1.00 93.58  ? 89  PRO A CB    1 
ATOM 1054 C CG    . PRO D 2 77  ? 188.911 204.826 214.786 1.00 93.58  ? 89  PRO A CG    1 
ATOM 1055 C CD    . PRO D 2 77  ? 187.690 204.509 215.599 1.00 93.58  ? 89  PRO A CD    1 
ATOM 1056 N N     . LYS D 2 78  ? 186.322 207.423 213.867 1.00 92.33  ? 90  LYS A N     1 
ATOM 1057 C CA    . LYS D 2 78  ? 185.816 207.945 212.610 1.00 92.33  ? 90  LYS A CA    1 
ATOM 1058 C C     . LYS D 2 78  ? 184.885 209.135 212.820 1.00 92.33  ? 90  LYS A C     1 
ATOM 1059 O O     . LYS D 2 78  ? 184.808 210.006 211.946 1.00 92.33  ? 90  LYS A O     1 
ATOM 1060 C CB    . LYS D 2 78  ? 185.088 206.813 211.858 1.00 92.33  ? 90  LYS A CB    1 
ATOM 1061 C CG    . LYS D 2 78  ? 185.871 205.555 211.503 1.00 92.33  ? 90  LYS A CG    1 
ATOM 1062 C CD    . LYS D 2 78  ? 187.076 205.871 210.625 1.00 92.33  ? 90  LYS A CD    1 
ATOM 1063 C CE    . LYS D 2 78  ? 186.657 206.294 209.236 1.00 92.33  ? 90  LYS A CE    1 
ATOM 1064 N NZ    . LYS D 2 78  ? 187.844 206.430 208.363 1.00 92.33  ? 90  LYS A NZ    1 
ATOM 1065 N N     . LYS D 2 79  ? 184.227 209.224 213.976 1.00 88.74  ? 91  LYS A N     1 
ATOM 1066 C CA    . LYS D 2 79  ? 183.227 210.245 214.250 1.00 88.74  ? 91  LYS A CA    1 
ATOM 1067 C C     . LYS D 2 79  ? 183.642 211.072 215.460 1.00 88.74  ? 91  LYS A C     1 
ATOM 1068 O O     . LYS D 2 79  ? 184.460 210.641 216.276 1.00 88.74  ? 91  LYS A O     1 
ATOM 1069 C CB    . LYS D 2 79  ? 181.851 209.616 214.510 1.00 88.74  ? 91  LYS A CB    1 
ATOM 1070 C CG    . LYS D 2 79  ? 181.235 208.939 213.296 1.00 88.74  ? 91  LYS A CG    1 
ATOM 1071 C CD    . LYS D 2 79  ? 179.887 208.318 213.632 1.00 88.74  ? 91  LYS A CD    1 
ATOM 1072 C CE    . LYS D 2 79  ? 179.251 207.660 212.420 1.00 88.74  ? 91  LYS A CE    1 
ATOM 1073 N NZ    . LYS D 2 79  ? 177.946 207.031 212.747 1.00 88.74  ? 91  LYS A NZ    1 
ATOM 1074 N N     . THR D 2 80  ? 183.069 212.269 215.564 1.00 86.75  ? 92  THR A N     1 
ATOM 1075 C CA    . THR D 2 80  ? 183.295 213.168 216.688 1.00 86.75  ? 92  THR A CA    1 
ATOM 1076 C C     . THR D 2 80  ? 181.991 213.407 217.440 1.00 86.75  ? 92  THR A C     1 
ATOM 1077 O O     . THR D 2 80  ? 180.894 213.165 216.930 1.00 86.75  ? 92  THR A O     1 
ATOM 1078 C CB    . THR D 2 80  ? 183.878 214.510 216.226 1.00 86.75  ? 92  THR A CB    1 
ATOM 1079 O OG1   . THR D 2 80  ? 183.165 214.974 215.073 1.00 86.75  ? 92  THR A OG1   1 
ATOM 1080 C CG2   . THR D 2 80  ? 185.350 214.369 215.890 1.00 86.75  ? 92  THR A CG2   1 
ATOM 1081 N N     . GLY D 2 81  ? 182.126 213.903 218.669 1.00 87.89  ? 93  GLY A N     1 
ATOM 1082 C CA    . GLY D 2 81  ? 180.989 214.242 219.498 1.00 87.89  ? 93  GLY A CA    1 
ATOM 1083 C C     . GLY D 2 81  ? 181.212 215.575 220.181 1.00 87.89  ? 93  GLY A C     1 
ATOM 1084 O O     . GLY D 2 81  ? 182.326 216.101 220.216 1.00 87.89  ? 93  GLY A O     1 
ATOM 1085 N N     . GLY D 2 82  ? 180.130 216.127 220.722 1.00 78.37  ? 94  GLY A N     1 
ATOM 1086 C CA    . GLY D 2 82  ? 180.185 217.389 221.418 1.00 78.37  ? 94  GLY A CA    1 
ATOM 1087 C C     . GLY D 2 82  ? 178.850 217.762 222.030 1.00 78.37  ? 94  GLY A C     1 
ATOM 1088 O O     . GLY D 2 82  ? 177.785 217.413 221.513 1.00 78.37  ? 94  GLY A O     1 
ATOM 1089 N N     . PRO D 2 83  ? 178.883 218.483 223.151 1.00 77.45  ? 95  PRO A N     1 
ATOM 1090 C CA    . PRO D 2 83  ? 177.631 218.852 223.825 1.00 77.45  ? 95  PRO A CA    1 
ATOM 1091 C C     . PRO D 2 83  ? 176.840 219.860 223.004 1.00 77.45  ? 95  PRO A C     1 
ATOM 1092 O O     . PRO D 2 83  ? 177.378 220.869 222.545 1.00 77.45  ? 95  PRO A O     1 
ATOM 1093 C CB    . PRO D 2 83  ? 178.104 219.457 225.155 1.00 77.45  ? 95  PRO A CB    1 
ATOM 1094 C CG    . PRO D 2 83  ? 179.541 219.044 225.296 1.00 77.45  ? 95  PRO A CG    1 
ATOM 1095 C CD    . PRO D 2 83  ? 180.068 218.918 223.906 1.00 77.45  ? 95  PRO A CD    1 
ATOM 1096 N N     . ILE D 2 84  ? 175.552 219.580 222.828 1.00 77.91  ? 96  ILE A N     1 
ATOM 1097 C CA    . ILE D 2 84  ? 174.638 220.462 222.116 1.00 77.91  ? 96  ILE A CA    1 
ATOM 1098 C C     . ILE D 2 84  ? 173.465 220.766 223.034 1.00 77.91  ? 96  ILE A C     1 
ATOM 1099 O O     . ILE D 2 84  ? 172.862 219.848 223.601 1.00 77.91  ? 96  ILE A O     1 
ATOM 1100 C CB    . ILE D 2 84  ? 174.149 219.839 220.795 1.00 77.91  ? 96  ILE A CB    1 
ATOM 1101 C CG1   . ILE D 2 84  ? 175.290 219.785 219.779 1.00 77.91  ? 96  ILE A CG1   1 
ATOM 1102 C CG2   . ILE D 2 84  ? 172.981 220.631 220.230 1.00 77.91  ? 96  ILE A CG2   1 
ATOM 1103 C CD1   . ILE D 2 84  ? 175.944 221.125 219.527 1.00 77.91  ? 96  ILE A CD1   1 
ATOM 1104 N N     . TYR D 2 85  ? 173.146 222.048 223.184 1.00 78.09  ? 97  TYR A N     1 
ATOM 1105 C CA    . TYR D 2 85  ? 172.082 222.497 224.071 1.00 78.09  ? 97  TYR A CA    1 
ATOM 1106 C C     . TYR D 2 85  ? 170.962 223.107 223.243 1.00 78.09  ? 97  TYR A C     1 
ATOM 1107 O O     . TYR D 2 85  ? 171.198 224.023 222.449 1.00 78.09  ? 97  TYR A O     1 
ATOM 1108 C CB    . TYR D 2 85  ? 172.613 223.506 225.091 1.00 78.09  ? 97  TYR A CB    1 
ATOM 1109 C CG    . TYR D 2 85  ? 173.862 223.036 225.798 1.00 78.09  ? 97  TYR A CG    1 
ATOM 1110 C CD1   . TYR D 2 85  ? 173.782 222.292 226.967 1.00 78.09  ? 97  TYR A CD1   1 
ATOM 1111 C CD2   . TYR D 2 85  ? 175.121 223.322 225.290 1.00 78.09  ? 97  TYR A CD2   1 
ATOM 1112 C CE1   . TYR D 2 85  ? 174.921 221.855 227.614 1.00 78.09  ? 97  TYR A CE1   1 
ATOM 1113 C CE2   . TYR D 2 85  ? 176.265 222.889 225.929 1.00 78.09  ? 97  TYR A CE2   1 
ATOM 1114 C CZ    . TYR D 2 85  ? 176.159 222.156 227.090 1.00 78.09  ? 97  TYR A CZ    1 
ATOM 1115 O OH    . TYR D 2 85  ? 177.297 221.724 227.729 1.00 78.09  ? 97  TYR A OH    1 
ATOM 1116 N N     . ARG D 2 86  ? 169.748 222.596 223.432 1.00 81.99  ? 98  ARG A N     1 
ATOM 1117 C CA    . ARG D 2 86  ? 168.579 223.048 222.696 1.00 81.99  ? 98  ARG A CA    1 
ATOM 1118 C C     . ARG D 2 86  ? 167.450 223.343 223.672 1.00 81.99  ? 98  ARG A C     1 
ATOM 1119 O O     . ARG D 2 86  ? 167.386 222.769 224.763 1.00 81.99  ? 98  ARG A O     1 
ATOM 1120 C CB    . ARG D 2 86  ? 168.135 222.005 221.664 1.00 81.99  ? 98  ARG A CB    1 
ATOM 1121 C CG    . ARG D 2 86  ? 168.142 220.579 222.188 1.00 81.99  ? 98  ARG A CG    1 
ATOM 1122 C CD    . ARG D 2 86  ? 167.963 219.559 221.071 1.00 81.99  ? 98  ARG A CD    1 
ATOM 1123 N NE    . ARG D 2 86  ? 169.030 219.627 220.079 1.00 81.99  ? 98  ARG A NE    1 
ATOM 1124 C CZ    . ARG D 2 86  ? 168.931 220.240 218.907 1.00 81.99  ? 98  ARG A CZ    1 
ATOM 1125 N NH1   . ARG D 2 86  ? 167.819 220.857 218.541 1.00 81.99  ? 98  ARG A NH1   1 
ATOM 1126 N NH2   . ARG D 2 86  ? 169.973 220.234 218.082 1.00 81.99  ? 98  ARG A NH2   1 
ATOM 1127 N N     . ARG D 2 87  ? 166.560 224.247 223.273 1.00 83.56  ? 99  ARG A N     1 
ATOM 1128 C CA    . ARG D 2 87  ? 165.490 224.732 224.135 1.00 83.56  ? 99  ARG A CA    1 
ATOM 1129 C C     . ARG D 2 87  ? 164.138 224.409 223.514 1.00 83.56  ? 99  ARG A C     1 
ATOM 1130 O O     . ARG D 2 87  ? 163.849 224.835 222.390 1.00 83.56  ? 99  ARG A O     1 
ATOM 1131 C CB    . ARG D 2 87  ? 165.620 226.238 224.363 1.00 83.56  ? 99  ARG A CB    1 
ATOM 1132 C CG    . ARG D 2 87  ? 164.655 226.796 225.394 1.00 83.56  ? 99  ARG A CG    1 
ATOM 1133 C CD    . ARG D 2 87  ? 165.094 228.170 225.876 1.00 83.56  ? 99  ARG A CD    1 
ATOM 1134 N NE    . ARG D 2 87  ? 164.924 229.187 224.845 1.00 83.56  ? 99  ARG A NE    1 
ATOM 1135 C CZ    . ARG D 2 87  ? 164.958 230.494 225.068 1.00 83.56  ? 99  ARG A CZ    1 
ATOM 1136 N NH1   . ARG D 2 87  ? 165.160 230.983 226.280 1.00 83.56  ? 99  ARG A NH1   1 
ATOM 1137 N NH2   . ARG D 2 87  ? 164.783 231.330 224.048 1.00 83.56  ? 99  ARG A NH2   1 
ATOM 1138 N N     . VAL D 2 88  ? 163.317 223.659 224.245 1.00 81.14  ? 100 VAL A N     1 
ATOM 1139 C CA    . VAL D 2 88  ? 161.902 223.494 223.928 1.00 81.14  ? 100 VAL A CA    1 
ATOM 1140 C C     . VAL D 2 88  ? 161.126 223.655 225.226 1.00 81.14  ? 100 VAL A C     1 
ATOM 1141 O O     . VAL D 2 88  ? 161.547 223.148 226.272 1.00 81.14  ? 100 VAL A O     1 
ATOM 1142 C CB    . VAL D 2 88  ? 161.594 222.137 223.260 1.00 81.14  ? 100 VAL A CB    1 
ATOM 1143 C CG1   . VAL D 2 88  ? 162.121 220.983 224.092 1.00 81.14  ? 100 VAL A CG1   1 
ATOM 1144 C CG2   . VAL D 2 88  ? 160.099 221.986 223.010 1.00 81.14  ? 100 VAL A CG2   1 
ATOM 1145 N N     . ASP D 2 89  ? 160.014 224.392 225.166 1.00 79.03  ? 101 ASP A N     1 
ATOM 1146 C CA    . ASP D 2 89  ? 159.209 224.726 226.343 1.00 79.03  ? 101 ASP A CA    1 
ATOM 1147 C C     . ASP D 2 89  ? 159.999 225.565 227.345 1.00 79.03  ? 101 ASP A C     1 
ATOM 1148 O O     . ASP D 2 89  ? 159.649 225.635 228.526 1.00 79.03  ? 101 ASP A O     1 
ATOM 1149 C CB    . ASP D 2 89  ? 158.646 223.472 227.019 1.00 79.03  ? 101 ASP A CB    1 
ATOM 1150 C CG    . ASP D 2 89  ? 157.557 222.810 226.200 1.00 79.03  ? 101 ASP A CG    1 
ATOM 1151 O OD1   . ASP D 2 89  ? 157.061 223.445 225.245 1.00 79.03  ? 101 ASP A OD1   1 
ATOM 1152 O OD2   . ASP D 2 89  ? 157.196 221.656 226.510 1.00 79.03  ? 101 ASP A OD2   1 
ATOM 1153 N N     . GLY D 2 90  ? 161.073 226.205 226.883 1.00 78.62  ? 102 GLY A N     1 
ATOM 1154 C CA    . GLY D 2 90  ? 161.841 227.131 227.682 1.00 78.62  ? 102 GLY A CA    1 
ATOM 1155 C C     . GLY D 2 90  ? 162.951 226.509 228.508 1.00 78.62  ? 102 GLY A C     1 
ATOM 1156 O O     . GLY D 2 90  ? 163.677 227.236 229.193 1.00 78.62  ? 102 GLY A O     1 
ATOM 1157 N N     . LYS D 2 91  ? 163.102 225.190 228.464 1.00 79.73  ? 103 LYS A N     1 
ATOM 1158 C CA    . LYS D 2 91  ? 164.053 224.500 229.322 1.00 79.73  ? 103 LYS A CA    1 
ATOM 1159 C C     . LYS D 2 91  ? 165.214 223.936 228.509 1.00 79.73  ? 103 LYS A C     1 
ATOM 1160 O O     . LYS D 2 91  ? 165.027 223.368 227.431 1.00 79.73  ? 103 LYS A O     1 
ATOM 1161 C CB    . LYS D 2 91  ? 163.366 223.376 230.098 1.00 79.73  ? 103 LYS A CB    1 
ATOM 1162 C CG    . LYS D 2 91  ? 162.361 223.874 231.113 1.00 79.73  ? 103 LYS A CG    1 
ATOM 1163 C CD    . LYS D 2 91  ? 161.711 222.694 231.818 1.00 79.73  ? 103 LYS A CD    1 
ATOM 1164 C CE    . LYS D 2 91  ? 160.712 223.143 232.863 1.00 79.73  ? 103 LYS A CE    1 
ATOM 1165 N NZ    . LYS D 2 91  ? 160.054 221.993 233.541 1.00 79.73  ? 103 LYS A NZ    1 
ATOM 1166 N N     . TRP D 2 92  ? 166.420 224.104 229.043 1.00 81.32  ? 104 TRP A N     1 
ATOM 1167 C CA    . TRP D 2 92  ? 167.646 223.655 228.400 1.00 81.32  ? 104 TRP A CA    1 
ATOM 1168 C C     . TRP D 2 92  ? 167.963 222.206 228.758 1.00 81.32  ? 104 TRP A C     1 
ATOM 1169 O O     . TRP D 2 92  ? 167.822 221.775 229.905 1.00 81.32  ? 104 TRP A O     1 
ATOM 1170 C CB    . TRP D 2 92  ? 168.819 224.550 228.803 1.00 81.32  ? 104 TRP A CB    1 
ATOM 1171 C CG    . TRP D 2 92  ? 168.752 225.922 228.227 1.00 81.32  ? 104 TRP A CG    1 
ATOM 1172 C CD1   . TRP D 2 92  ? 168.591 227.090 228.911 1.00 81.32  ? 104 TRP A CD1   1 
ATOM 1173 C CD2   . TRP D 2 92  ? 168.868 226.277 226.846 1.00 81.32  ? 104 TRP A CD2   1 
ATOM 1174 N NE1   . TRP D 2 92  ? 168.586 228.151 228.039 1.00 81.32  ? 104 TRP A NE1   1 
ATOM 1175 C CE2   . TRP D 2 92  ? 168.756 227.678 226.765 1.00 81.32  ? 104 TRP A CE2   1 
ATOM 1176 C CE3   . TRP D 2 92  ? 169.050 225.546 225.669 1.00 81.32  ? 104 TRP A CE3   1 
ATOM 1177 C CZ2   . TRP D 2 92  ? 168.820 228.362 225.555 1.00 81.32  ? 104 TRP A CZ2   1 
ATOM 1178 C CZ3   . TRP D 2 92  ? 169.115 226.227 224.468 1.00 81.32  ? 104 TRP A CZ3   1 
ATOM 1179 C CH2   . TRP D 2 92  ? 168.998 227.621 224.420 1.00 81.32  ? 104 TRP A CH2   1 
ATOM 1180 N N     . ARG D 2 93  ? 168.398 221.454 227.749 1.00 82.39  ? 105 ARG A N     1 
ATOM 1181 C CA    . ARG D 2 93  ? 168.892 220.098 227.942 1.00 82.39  ? 105 ARG A CA    1 
ATOM 1182 C C     . ARG D 2 93  ? 170.106 219.894 227.048 1.00 82.39  ? 105 ARG A C     1 
ATOM 1183 O O     . ARG D 2 93  ? 170.276 220.578 226.036 1.00 82.39  ? 105 ARG A O     1 
ATOM 1184 C CB    . ARG D 2 93  ? 167.828 219.037 227.630 1.00 82.39  ? 105 ARG A CB    1 
ATOM 1185 C CG    . ARG D 2 93  ? 166.412 219.417 228.017 1.00 82.39  ? 105 ARG A CG    1 
ATOM 1186 C CD    . ARG D 2 93  ? 165.412 218.824 227.045 1.00 82.39  ? 105 ARG A CD    1 
ATOM 1187 N NE    . ARG D 2 93  ? 165.594 219.364 225.703 1.00 82.39  ? 105 ARG A NE    1 
ATOM 1188 C CZ    . ARG D 2 93  ? 165.224 220.580 225.326 1.00 82.39  ? 105 ARG A CZ    1 
ATOM 1189 N NH1   . ARG D 2 93  ? 164.644 221.420 226.168 1.00 82.39  ? 105 ARG A NH1   1 
ATOM 1190 N NH2   . ARG D 2 93  ? 165.441 220.963 224.071 1.00 82.39  ? 105 ARG A NH2   1 
ATOM 1191 N N     . ARG D 2 94  ? 170.949 218.941 227.431 1.00 80.16  ? 106 ARG A N     1 
ATOM 1192 C CA    . ARG D 2 94  ? 172.148 218.602 226.679 1.00 80.16  ? 106 ARG A CA    1 
ATOM 1193 C C     . ARG D 2 94  ? 171.985 217.228 226.047 1.00 80.16  ? 106 ARG A C     1 
ATOM 1194 O O     . ARG D 2 94  ? 171.626 216.264 226.732 1.00 80.16  ? 106 ARG A O     1 
ATOM 1195 C CB    . ARG D 2 94  ? 173.390 218.619 227.573 1.00 80.16  ? 106 ARG A CB    1 
ATOM 1196 C CG    . ARG D 2 94  ? 174.625 218.040 226.897 1.00 80.16  ? 106 ARG A CG    1 
ATOM 1197 C CD    . ARG D 2 94  ? 175.824 217.989 227.827 1.00 80.16  ? 106 ARG A CD    1 
ATOM 1198 N NE    . ARG D 2 94  ? 175.446 217.748 229.213 1.00 80.16  ? 106 ARG A NE    1 
ATOM 1199 C CZ    . ARG D 2 94  ? 175.654 218.604 230.203 1.00 80.16  ? 106 ARG A CZ    1 
ATOM 1200 N NH1   . ARG D 2 94  ? 176.235 219.773 229.993 1.00 80.16  ? 106 ARG A NH1   1 
ATOM 1201 N NH2   . ARG D 2 94  ? 175.267 218.281 231.433 1.00 80.16  ? 106 ARG A NH2   1 
ATOM 1202 N N     . GLU D 2 95  ? 172.249 217.142 224.747 1.00 79.49  ? 107 GLU A N     1 
ATOM 1203 C CA    . GLU D 2 95  ? 172.244 215.877 224.030 1.00 79.49  ? 107 GLU A CA    1 
ATOM 1204 C C     . GLU D 2 95  ? 173.497 215.783 223.171 1.00 79.49  ? 107 GLU A C     1 
ATOM 1205 O O     . GLU D 2 95  ? 174.005 216.790 222.673 1.00 79.49  ? 107 GLU A O     1 
ATOM 1206 C CB    . GLU D 2 95  ? 170.966 215.717 223.180 1.00 79.49  ? 107 GLU A CB    1 
ATOM 1207 C CG    . GLU D 2 95  ? 170.823 214.392 222.440 1.00 79.49  ? 107 GLU A CG    1 
ATOM 1208 C CD    . GLU D 2 95  ? 169.527 214.279 221.664 1.00 79.49  ? 107 GLU A CD    1 
ATOM 1209 O OE1   . GLU D 2 95  ? 168.745 215.253 221.667 1.00 79.49  ? 107 GLU A OE1   1 
ATOM 1210 O OE2   . GLU D 2 95  ? 169.288 213.215 221.055 1.00 79.49  ? 107 GLU A OE2   1 
ATOM 1211 N N     . LEU D 2 96  ? 173.993 214.561 223.010 1.00 76.50  ? 108 LEU A N     1 
ATOM 1212 C CA    . LEU D 2 96  ? 175.252 214.304 222.324 1.00 76.50  ? 108 LEU A CA    1 
ATOM 1213 C C     . LEU D 2 96  ? 174.970 213.925 220.876 1.00 76.50  ? 108 LEU A C     1 
ATOM 1214 O O     . LEU D 2 96  ? 174.217 212.982 220.613 1.00 76.50  ? 108 LEU A O     1 
ATOM 1215 C CB    . LEU D 2 96  ? 176.032 213.193 223.027 1.00 76.50  ? 108 LEU A CB    1 
ATOM 1216 C CG    . LEU D 2 96  ? 177.485 212.992 222.599 1.00 76.50  ? 108 LEU A CG    1 
ATOM 1217 C CD1   . LEU D 2 96  ? 178.263 214.284 222.754 1.00 76.50  ? 108 LEU A CD1   1 
ATOM 1218 C CD2   . LEU D 2 96  ? 178.130 211.875 223.400 1.00 76.50  ? 108 LEU A CD2   1 
ATOM 1219 N N     . ILE D 2 97  ? 175.572 214.656 219.945 1.00 81.93  ? 109 ILE A N     1 
ATOM 1220 C CA    . ILE D 2 97  ? 175.415 214.383 218.528 1.00 81.93  ? 109 ILE A CA    1 
ATOM 1221 C C     . ILE D 2 97  ? 176.655 213.663 218.019 1.00 81.93  ? 109 ILE A C     1 
ATOM 1222 O O     . ILE D 2 97  ? 177.765 213.827 218.533 1.00 81.93  ? 109 ILE A O     1 
ATOM 1223 C CB    . ILE D 2 97  ? 175.151 215.671 217.716 1.00 81.93  ? 109 ILE A CB    1 
ATOM 1224 C CG1   . ILE D 2 97  ? 173.799 216.279 218.095 1.00 81.93  ? 109 ILE A CG1   1 
ATOM 1225 C CG2   . ILE D 2 97  ? 175.227 215.387 216.226 1.00 81.93  ? 109 ILE A CG2   1 
ATOM 1226 C CD1   . ILE D 2 97  ? 173.576 217.672 217.547 1.00 81.93  ? 109 ILE A CD1   1 
ATOM 1227 N N     . LEU D 2 98  ? 176.462 212.853 216.982 1.00 88.19  ? 110 LEU A N     1 
ATOM 1228 C CA    . LEU D 2 98  ? 177.541 212.104 216.352 1.00 88.19  ? 110 LEU A CA    1 
ATOM 1229 C C     . LEU D 2 98  ? 177.630 212.531 214.896 1.00 88.19  ? 110 LEU A C     1 
ATOM 1230 O O     . LEU D 2 98  ? 176.695 212.298 214.123 1.00 88.19  ? 110 LEU A O     1 
ATOM 1231 C CB    . LEU D 2 98  ? 177.297 210.596 216.462 1.00 88.19  ? 110 LEU A CB    1 
ATOM 1232 C CG    . LEU D 2 98  ? 178.156 209.818 217.459 1.00 88.19  ? 110 LEU A CG    1 
ATOM 1233 C CD1   . LEU D 2 98  ? 178.070 208.330 217.174 1.00 88.19  ? 110 LEU A CD1   1 
ATOM 1234 C CD2   . LEU D 2 98  ? 179.593 210.290 217.394 1.00 88.19  ? 110 LEU A CD2   1 
ATOM 1235 N N     . TYR D 2 99  ? 178.748 213.149 214.524 1.00 88.85  ? 111 TYR A N     1 
ATOM 1236 C CA    . TYR D 2 99  ? 178.953 213.652 213.174 1.00 88.85  ? 111 TYR A CA    1 
ATOM 1237 C C     . TYR D 2 99  ? 180.261 213.130 212.602 1.00 88.85  ? 111 TYR A C     1 
ATOM 1238 O O     . TYR D 2 99  ? 181.251 212.956 213.317 1.00 88.85  ? 111 TYR A O     1 
ATOM 1239 C CB    . TYR D 2 99  ? 178.943 215.185 213.129 1.00 88.85  ? 111 TYR A CB    1 
ATOM 1240 C CG    . TYR D 2 99  ? 177.606 215.764 212.739 1.00 88.85  ? 111 TYR A CG    1 
ATOM 1241 C CD1   . TYR D 2 99  ? 176.439 215.364 213.374 1.00 88.85  ? 111 TYR A CD1   1 
ATOM 1242 C CD2   . TYR D 2 99  ? 177.510 216.698 211.718 1.00 88.85  ? 111 TYR A CD2   1 
ATOM 1243 C CE1   . TYR D 2 99  ? 175.215 215.888 213.011 1.00 88.85  ? 111 TYR A CE1   1 
ATOM 1244 C CE2   . TYR D 2 99  ? 176.295 217.225 211.348 1.00 88.85  ? 111 TYR A CE2   1 
ATOM 1245 C CZ    . TYR D 2 99  ? 175.149 216.818 211.997 1.00 88.85  ? 111 TYR A CZ    1 
ATOM 1246 O OH    . TYR D 2 99  ? 173.932 217.345 211.629 1.00 88.85  ? 111 TYR A OH    1 
ATOM 1247 N N     . ASP D 2 100 ? 180.247 212.883 211.295 1.00 91.21  ? 112 ASP A N     1 
ATOM 1248 C CA    . ASP D 2 100 ? 181.401 212.308 210.620 1.00 91.21  ? 112 ASP A CA    1 
ATOM 1249 C C     . ASP D 2 100 ? 182.528 213.327 210.530 1.00 91.21  ? 112 ASP A C     1 
ATOM 1250 O O     . ASP D 2 100 ? 182.305 214.480 210.152 1.00 91.21  ? 112 ASP A O     1 
ATOM 1251 C CB    . ASP D 2 100 ? 181.012 211.837 209.219 1.00 91.21  ? 112 ASP A CB    1 
ATOM 1252 C CG    . ASP D 2 100 ? 180.128 210.608 209.242 1.00 91.21  ? 112 ASP A CG    1 
ATOM 1253 O OD1   . ASP D 2 100 ? 180.045 209.953 210.303 1.00 91.21  ? 112 ASP A OD1   1 
ATOM 1254 O OD2   . ASP D 2 100 ? 179.526 210.287 208.197 1.00 91.21  ? 112 ASP A OD2   1 
ATOM 1255 N N     . LYS D 2 101 ? 183.746 212.895 210.868 1.00 86.92  ? 113 LYS A N     1 
ATOM 1256 C CA    . LYS D 2 101 ? 184.913 213.746 210.661 1.00 86.92  ? 113 LYS A CA    1 
ATOM 1257 C C     . LYS D 2 101 ? 185.057 214.123 209.193 1.00 86.92  ? 113 LYS A C     1 
ATOM 1258 O O     . LYS D 2 101 ? 185.390 215.269 208.866 1.00 86.92  ? 113 LYS A O     1 
ATOM 1259 C CB    . LYS D 2 101 ? 186.175 213.039 211.154 1.00 86.92  ? 113 LYS A CB    1 
ATOM 1260 C CG    . LYS D 2 101 ? 186.641 213.461 212.537 1.00 86.92  ? 113 LYS A CG    1 
ATOM 1261 C CD    . LYS D 2 101 ? 187.934 212.753 212.910 1.00 86.92  ? 113 LYS A CD    1 
ATOM 1262 C CE    . LYS D 2 101 ? 188.052 212.558 214.411 1.00 86.92  ? 113 LYS A CE    1 
ATOM 1263 N NZ    . LYS D 2 101 ? 187.081 211.553 214.923 1.00 86.92  ? 113 LYS A NZ    1 
ATOM 1264 N N     . GLU D 2 102 ? 184.809 213.168 208.293 1.00 87.72  ? 114 GLU A N     1 
ATOM 1265 C CA    . GLU D 2 102 ? 184.864 213.459 206.865 1.00 87.72  ? 114 GLU A CA    1 
ATOM 1266 C C     . GLU D 2 102 ? 183.824 214.500 206.473 1.00 87.72  ? 114 GLU A C     1 
ATOM 1267 O O     . GLU D 2 102 ? 184.105 215.393 205.666 1.00 87.72  ? 114 GLU A O     1 
ATOM 1268 C CB    . GLU D 2 102 ? 184.667 212.176 206.057 1.00 87.72  ? 114 GLU A CB    1 
ATOM 1269 C CG    . GLU D 2 102 ? 183.313 211.507 206.246 1.00 87.72  ? 114 GLU A CG    1 
ATOM 1270 C CD    . GLU D 2 102 ? 183.196 210.176 205.526 1.00 87.72  ? 114 GLU A CD    1 
ATOM 1271 O OE1   . GLU D 2 102 ? 184.010 209.923 204.614 1.00 87.72  ? 114 GLU A OE1   1 
ATOM 1272 O OE2   . GLU D 2 102 ? 182.308 209.370 205.880 1.00 87.72  ? 114 GLU A OE2   1 
ATOM 1273 N N     . GLU D 2 103 ? 182.614 214.399 207.027 1.00 87.34  ? 115 GLU A N     1 
ATOM 1274 C CA    . GLU D 2 103 ? 181.581 215.384 206.722 1.00 87.34  ? 115 GLU A CA    1 
ATOM 1275 C C     . GLU D 2 103 ? 181.964 216.768 207.233 1.00 87.34  ? 115 GLU A C     1 
ATOM 1276 O O     . GLU D 2 103 ? 181.754 217.772 206.542 1.00 87.34  ? 115 GLU A O     1 
ATOM 1277 C CB    . GLU D 2 103 ? 180.243 214.944 207.311 1.00 87.34  ? 115 GLU A CB    1 
ATOM 1278 C CG    . GLU D 2 103 ? 179.128 215.961 207.130 1.00 87.34  ? 115 GLU A CG    1 
ATOM 1279 C CD    . GLU D 2 103 ? 178.547 215.948 205.729 1.00 87.34  ? 115 GLU A CD    1 
ATOM 1280 O OE1   . GLU D 2 103 ? 178.854 215.011 204.962 1.00 87.34  ? 115 GLU A OE1   1 
ATOM 1281 O OE2   . GLU D 2 103 ? 177.784 216.878 205.394 1.00 87.34  ? 115 GLU A OE2   1 
ATOM 1282 N N     . ILE D 2 104 ? 182.528 216.843 208.441 1.00 84.34  ? 116 ILE A N     1 
ATOM 1283 C CA    . ILE D 2 104 ? 182.963 218.131 208.976 1.00 84.34  ? 116 ILE A CA    1 
ATOM 1284 C C     . ILE D 2 104 ? 184.055 218.726 208.098 1.00 84.34  ? 116 ILE A C     1 
ATOM 1285 O O     . ILE D 2 104 ? 184.049 219.928 207.799 1.00 84.34  ? 116 ILE A O     1 
ATOM 1286 C CB    . ILE D 2 104 ? 183.435 217.978 210.435 1.00 84.34  ? 116 ILE A CB    1 
ATOM 1287 C CG1   . ILE D 2 104 ? 182.353 217.318 211.291 1.00 84.34  ? 116 ILE A CG1   1 
ATOM 1288 C CG2   . ILE D 2 104 ? 183.823 219.330 211.014 1.00 84.34  ? 116 ILE A CG2   1 
ATOM 1289 C CD1   . ILE D 2 104 ? 181.253 218.248 211.732 1.00 84.34  ? 116 ILE A CD1   1 
ATOM 1290 N N     . ARG D 2 105 ? 185.010 217.897 207.671 1.00 83.54  ? 117 ARG A N     1 
ATOM 1291 C CA    . ARG D 2 105 ? 186.080 218.380 206.806 1.00 83.54  ? 117 ARG A CA    1 
ATOM 1292 C C     . ARG D 2 105 ? 185.535 218.862 205.467 1.00 83.54  ? 117 ARG A C     1 
ATOM 1293 O O     . ARG D 2 105 ? 185.974 219.894 204.946 1.00 83.54  ? 117 ARG A O     1 
ATOM 1294 C CB    . ARG D 2 105 ? 187.122 217.281 206.601 1.00 83.54  ? 117 ARG A CB    1 
ATOM 1295 C CG    . ARG D 2 105 ? 188.110 217.154 207.746 1.00 83.54  ? 117 ARG A CG    1 
ATOM 1296 C CD    . ARG D 2 105 ? 189.332 216.352 207.339 1.00 83.54  ? 117 ARG A CD    1 
ATOM 1297 N NE    . ARG D 2 105 ? 189.042 214.927 207.237 1.00 83.54  ? 117 ARG A NE    1 
ATOM 1298 C CZ    . ARG D 2 105 ? 189.055 214.089 208.264 1.00 83.54  ? 117 ARG A CZ    1 
ATOM 1299 N NH1   . ARG D 2 105 ? 189.333 214.501 209.489 1.00 83.54  ? 117 ARG A NH1   1 
ATOM 1300 N NH2   . ARG D 2 105 ? 188.782 212.804 208.056 1.00 83.54  ? 117 ARG A NH2   1 
ATOM 1301 N N     . ARG D 2 106 ? 184.582 218.125 204.892 1.00 83.94  ? 118 ARG A N     1 
ATOM 1302 C CA    . ARG D 2 106 ? 183.988 218.536 203.625 1.00 83.94  ? 118 ARG A CA    1 
ATOM 1303 C C     . ARG D 2 106 ? 183.243 219.857 203.769 1.00 83.94  ? 118 ARG A C     1 
ATOM 1304 O O     . ARG D 2 106 ? 183.325 220.723 202.890 1.00 83.94  ? 118 ARG A O     1 
ATOM 1305 C CB    . ARG D 2 106 ? 183.053 217.443 203.108 1.00 83.94  ? 118 ARG A CB    1 
ATOM 1306 C CG    . ARG D 2 106 ? 182.279 217.822 201.857 1.00 83.94  ? 118 ARG A CG    1 
ATOM 1307 C CD    . ARG D 2 106 ? 181.129 216.858 201.610 1.00 83.94  ? 118 ARG A CD    1 
ATOM 1308 N NE    . ARG D 2 106 ? 180.033 217.057 202.550 1.00 83.94  ? 118 ARG A NE    1 
ATOM 1309 C CZ    . ARG D 2 106 ? 179.123 218.017 202.449 1.00 83.94  ? 118 ARG A CZ    1 
ATOM 1310 N NH1   . ARG D 2 106 ? 179.145 218.888 201.454 1.00 83.94  ? 118 ARG A NH1   1 
ATOM 1311 N NH2   . ARG D 2 106 ? 178.168 218.104 203.370 1.00 83.94  ? 118 ARG A NH2   1 
ATOM 1312 N N     . ILE D 2 107 ? 182.513 220.030 204.873 1.00 79.82  ? 119 ILE A N     1 
ATOM 1313 C CA    . ILE D 2 107 ? 181.815 221.289 205.112 1.00 79.82  ? 119 ILE A CA    1 
ATOM 1314 C C     . ILE D 2 107 ? 182.811 222.433 205.255 1.00 79.82  ? 119 ILE A C     1 
ATOM 1315 O O     . ILE D 2 107 ? 182.604 223.527 204.717 1.00 79.82  ? 119 ILE A O     1 
ATOM 1316 C CB    . ILE D 2 107 ? 180.903 221.170 206.347 1.00 79.82  ? 119 ILE A CB    1 
ATOM 1317 C CG1   . ILE D 2 107 ? 179.761 220.192 206.073 1.00 79.82  ? 119 ILE A CG1   1 
ATOM 1318 C CG2   . ILE D 2 107 ? 180.346 222.529 206.734 1.00 79.82  ? 119 ILE A CG2   1 
ATOM 1319 C CD1   . ILE D 2 107 ? 178.982 219.802 207.309 1.00 79.82  ? 119 ILE A CD1   1 
ATOM 1320 N N     . TRP D 2 108 ? 183.908 222.200 205.982 1.00 77.76  ? 120 TRP A N     1 
ATOM 1321 C CA    . TRP D 2 108 ? 184.918 223.241 206.146 1.00 77.76  ? 120 TRP A CA    1 
ATOM 1322 C C     . TRP D 2 108 ? 185.545 223.622 204.811 1.00 77.76  ? 120 TRP A C     1 
ATOM 1323 O O     . TRP D 2 108 ? 185.751 224.809 204.530 1.00 77.76  ? 120 TRP A O     1 
ATOM 1324 C CB    . TRP D 2 108 ? 185.994 222.782 207.129 1.00 77.76  ? 120 TRP A CB    1 
ATOM 1325 C CG    . TRP D 2 108 ? 187.113 223.765 207.295 1.00 77.76  ? 120 TRP A CG    1 
ATOM 1326 C CD1   . TRP D 2 108 ? 188.330 223.732 206.682 1.00 77.76  ? 120 TRP A CD1   1 
ATOM 1327 C CD2   . TRP D 2 108 ? 187.117 224.928 208.131 1.00 77.76  ? 120 TRP A CD2   1 
ATOM 1328 N NE1   . TRP D 2 108 ? 189.093 224.801 207.083 1.00 77.76  ? 120 TRP A NE1   1 
ATOM 1329 C CE2   . TRP D 2 108 ? 188.372 225.549 207.975 1.00 77.76  ? 120 TRP A CE2   1 
ATOM 1330 C CE3   . TRP D 2 108 ? 186.184 225.503 208.998 1.00 77.76  ? 120 TRP A CE3   1 
ATOM 1331 C CZ2   . TRP D 2 108 ? 188.715 226.718 208.649 1.00 77.76  ? 120 TRP A CZ2   1 
ATOM 1332 C CZ3   . TRP D 2 108 ? 186.527 226.662 209.668 1.00 77.76  ? 120 TRP A CZ3   1 
ATOM 1333 C CH2   . TRP D 2 108 ? 187.782 227.257 209.490 1.00 77.76  ? 120 TRP A CH2   1 
ATOM 1334 N N     . ARG D 2 109 ? 185.862 222.630 203.977 1.00 82.20  ? 121 ARG A N     1 
ATOM 1335 C CA    . ARG D 2 109 ? 186.443 222.924 202.670 1.00 82.20  ? 121 ARG A CA    1 
ATOM 1336 C C     . ARG D 2 109 ? 185.458 223.672 201.779 1.00 82.20  ? 121 ARG A C     1 
ATOM 1337 O O     . ARG D 2 109 ? 185.837 224.629 201.095 1.00 82.20  ? 121 ARG A O     1 
ATOM 1338 C CB    . ARG D 2 109 ? 186.907 221.634 201.995 1.00 82.20  ? 121 ARG A CB    1 
ATOM 1339 C CG    . ARG D 2 109 ? 187.983 220.890 202.762 1.00 82.20  ? 121 ARG A CG    1 
ATOM 1340 C CD    . ARG D 2 109 ? 189.147 220.518 201.865 1.00 82.20  ? 121 ARG A CD    1 
ATOM 1341 N NE    . ARG D 2 109 ? 190.281 220.015 202.630 1.00 82.20  ? 121 ARG A NE    1 
ATOM 1342 C CZ    . ARG D 2 109 ? 190.377 218.781 203.105 1.00 82.20  ? 121 ARG A CZ    1 
ATOM 1343 N NH1   . ARG D 2 109 ? 189.418 217.889 202.912 1.00 82.20  ? 121 ARG A NH1   1 
ATOM 1344 N NH2   . ARG D 2 109 ? 191.461 218.432 203.791 1.00 82.20  ? 121 ARG A NH2   1 
ATOM 1345 N N     . GLN D 2 110 ? 184.191 223.252 201.775 1.00 80.94  ? 122 GLN A N     1 
ATOM 1346 C CA    . GLN D 2 110 ? 183.194 223.915 200.943 1.00 80.94  ? 122 GLN A CA    1 
ATOM 1347 C C     . GLN D 2 110 ? 182.966 225.352 201.393 1.00 80.94  ? 122 GLN A C     1 
ATOM 1348 O O     . GLN D 2 110 ? 182.810 226.255 200.561 1.00 80.94  ? 122 GLN A O     1 
ATOM 1349 C CB    . GLN D 2 110 ? 181.887 223.122 200.968 1.00 80.94  ? 122 GLN A CB    1 
ATOM 1350 C CG    . GLN D 2 110 ? 180.629 223.969 200.991 1.00 80.94  ? 122 GLN A CG    1 
ATOM 1351 C CD    . GLN D 2 110 ? 179.369 223.130 200.986 1.00 80.94  ? 122 GLN A CD    1 
ATOM 1352 O OE1   . GLN D 2 110 ? 179.429 221.900 200.978 1.00 80.94  ? 122 GLN A OE1   1 
ATOM 1353 N NE2   . GLN D 2 110 ? 178.217 223.790 200.993 1.00 80.94  ? 122 GLN A NE2   1 
ATOM 1354 N N     . ALA D 2 111 ? 182.954 225.587 202.706 1.00 78.33  ? 123 ALA A N     1 
ATOM 1355 C CA    . ALA D 2 111 ? 182.723 226.934 203.215 1.00 78.33  ? 123 ALA A CA    1 
ATOM 1356 C C     . ALA D 2 111 ? 183.894 227.862 202.921 1.00 78.33  ? 123 ALA A C     1 
ATOM 1357 O O     . ALA D 2 111 ? 183.761 229.083 203.052 1.00 78.33  ? 123 ALA A O     1 
ATOM 1358 C CB    . ALA D 2 111 ? 182.449 226.886 204.716 1.00 78.33  ? 123 ALA A CB    1 
ATOM 1359 N N     . ASN D 2 112 ? 185.044 227.310 202.533 1.00 82.43  ? 124 ASN A N     1 
ATOM 1360 C CA    . ASN D 2 112 ? 186.225 228.099 202.205 1.00 82.43  ? 124 ASN A CA    1 
ATOM 1361 C C     . ASN D 2 112 ? 186.605 227.990 200.732 1.00 82.43  ? 124 ASN A C     1 
ATOM 1362 O O     . ASN D 2 112 ? 187.792 228.051 200.394 1.00 82.43  ? 124 ASN A O     1 
ATOM 1363 C CB    . ASN D 2 112 ? 187.397 227.685 203.092 1.00 82.43  ? 124 ASN A CB    1 
ATOM 1364 C CG    . ASN D 2 112 ? 187.046 227.705 204.563 1.00 82.43  ? 124 ASN A CG    1 
ATOM 1365 O OD1   . ASN D 2 112 ? 186.101 228.374 204.979 1.00 82.43  ? 124 ASN A OD1   1 
ATOM 1366 N ND2   . ASN D 2 112 ? 187.802 226.963 205.359 1.00 82.43  ? 124 ASN A ND2   1 
ATOM 1367 N N     . ASN D 2 113 ? 185.614 227.830 199.853 1.00 83.52  ? 125 ASN A N     1 
ATOM 1368 C CA    . ASN D 2 113 ? 185.835 227.761 198.407 1.00 83.52  ? 125 ASN A CA    1 
ATOM 1369 C C     . ASN D 2 113 ? 186.806 226.641 198.041 1.00 83.52  ? 125 ASN A C     1 
ATOM 1370 O O     . ASN D 2 113 ? 187.670 226.800 197.177 1.00 83.52  ? 125 ASN A O     1 
ATOM 1371 C CB    . ASN D 2 113 ? 186.321 229.105 197.861 1.00 83.52  ? 125 ASN A CB    1 
ATOM 1372 C CG    . ASN D 2 113 ? 185.275 230.191 197.981 1.00 83.52  ? 125 ASN A CG    1 
ATOM 1373 O OD1   . ASN D 2 113 ? 184.219 229.986 198.577 1.00 83.52  ? 125 ASN A OD1   1 
ATOM 1374 N ND2   . ASN D 2 113 ? 185.564 231.357 197.416 1.00 83.52  ? 125 ASN A ND2   1 
ATOM 1375 N N     . GLY D 2 114 ? 186.663 225.497 198.706 1.00 85.82  ? 126 GLY A N     1 
ATOM 1376 C CA    . GLY D 2 114 ? 187.522 224.366 198.422 1.00 85.82  ? 126 GLY A CA    1 
ATOM 1377 C C     . GLY D 2 114 ? 188.952 224.519 198.884 1.00 85.82  ? 126 GLY A C     1 
ATOM 1378 O O     . GLY D 2 114 ? 189.838 223.846 198.352 1.00 85.82  ? 126 GLY A O     1 
ATOM 1379 N N     . ASP D 2 115 ? 189.206 225.384 199.859 1.00 86.27  ? 127 ASP A N     1 
ATOM 1380 C CA    . ASP D 2 115 ? 190.547 225.624 200.368 1.00 86.27  ? 127 ASP A CA    1 
ATOM 1381 C C     . ASP D 2 115 ? 190.589 225.141 201.812 1.00 86.27  ? 127 ASP A C     1 
ATOM 1382 O O     . ASP D 2 115 ? 189.602 225.261 202.544 1.00 86.27  ? 127 ASP A O     1 
ATOM 1383 C CB    . ASP D 2 115 ? 190.904 227.119 200.247 1.00 86.27  ? 127 ASP A CB    1 
ATOM 1384 C CG    . ASP D 2 115 ? 192.342 227.459 200.671 1.00 86.27  ? 127 ASP A CG    1 
ATOM 1385 O OD1   . ASP D 2 115 ? 193.060 226.506 201.042 1.00 86.27  ? 127 ASP A OD1   1 
ATOM 1386 O OD2   . ASP D 2 115 ? 192.777 228.628 200.655 1.00 86.27  ? 127 ASP A OD2   1 
ATOM 1387 N N     . ASP D 2 116 ? 191.733 224.581 202.212 1.00 85.48  ? 128 ASP A N     1 
ATOM 1388 C CA    . ASP D 2 116 ? 191.874 224.075 203.574 1.00 85.48  ? 128 ASP A CA    1 
ATOM 1389 C C     . ASP D 2 116 ? 191.712 225.197 204.591 1.00 85.48  ? 128 ASP A C     1 
ATOM 1390 O O     . ASP D 2 116 ? 191.011 225.042 205.598 1.00 85.48  ? 128 ASP A O     1 
ATOM 1391 C CB    . ASP D 2 116 ? 193.229 223.388 203.738 1.00 85.48  ? 128 ASP A CB    1 
ATOM 1392 C CG    . ASP D 2 116 ? 193.185 221.918 203.376 1.00 85.48  ? 128 ASP A CG    1 
ATOM 1393 O OD1   . ASP D 2 116 ? 192.099 221.431 203.000 1.00 85.48  ? 128 ASP A OD1   1 
ATOM 1394 O OD2   . ASP D 2 116 ? 194.237 221.250 203.462 1.00 85.48  ? 128 ASP A OD2   1 
ATOM 1395 N N     . ALA D 2 117 ? 192.345 226.340 204.332 1.00 78.84  ? 129 ALA A N     1 
ATOM 1396 C CA    . ALA D 2 117 ? 192.253 227.527 205.180 1.00 78.84  ? 129 ALA A CA    1 
ATOM 1397 C C     . ALA D 2 117 ? 192.623 227.204 206.627 1.00 78.84  ? 129 ALA A C     1 
ATOM 1398 O O     . ALA D 2 117 ? 191.805 227.278 207.545 1.00 78.84  ? 129 ALA A O     1 
ATOM 1399 C CB    . ALA D 2 117 ? 190.861 228.156 205.092 1.00 78.84  ? 129 ALA A CB    1 
ATOM 1400 N N     . THR D 2 118 ? 193.890 226.830 206.816 1.00 73.23  ? 130 THR A N     1 
ATOM 1401 C CA    . THR D 2 118 ? 194.402 226.583 208.157 1.00 73.23  ? 130 THR A CA    1 
ATOM 1402 C C     . THR D 2 118 ? 194.437 227.842 209.013 1.00 73.23  ? 130 THR A C     1 
ATOM 1403 O O     . THR D 2 118 ? 194.573 227.734 210.237 1.00 73.23  ? 130 THR A O     1 
ATOM 1404 C CB    . THR D 2 118 ? 195.803 225.975 208.084 1.00 73.23  ? 130 THR A CB    1 
ATOM 1405 O OG1   . THR D 2 118 ? 196.674 226.861 207.371 1.00 73.23  ? 130 THR A OG1   1 
ATOM 1406 C CG2   . THR D 2 118 ? 195.763 224.631 207.375 1.00 73.23  ? 130 THR A CG2   1 
ATOM 1407 N N     . ALA D 2 119 ? 194.322 229.025 208.403 1.00 71.50  ? 131 ALA A N     1 
ATOM 1408 C CA    . ALA D 2 119 ? 194.291 230.259 209.179 1.00 71.50  ? 131 ALA A CA    1 
ATOM 1409 C C     . ALA D 2 119 ? 193.073 230.307 210.092 1.00 71.50  ? 131 ALA A C     1 
ATOM 1410 O O     . ALA D 2 119 ? 193.172 230.728 211.249 1.00 71.50  ? 131 ALA A O     1 
ATOM 1411 C CB    . ALA D 2 119 ? 194.311 231.469 208.245 1.00 71.50  ? 131 ALA A CB    1 
ATOM 1412 N N     . GLY D 2 120 ? 191.914 229.879 209.590 1.00 70.93  ? 132 GLY A N     1 
ATOM 1413 C CA    . GLY D 2 120 ? 190.731 229.831 210.433 1.00 70.93  ? 132 GLY A CA    1 
ATOM 1414 C C     . GLY D 2 120 ? 190.874 228.849 211.579 1.00 70.93  ? 132 GLY A C     1 
ATOM 1415 O O     . GLY D 2 120 ? 190.449 229.124 212.706 1.00 70.93  ? 132 GLY A O     1 
ATOM 1416 N N     . LEU D 2 121 ? 191.474 227.689 211.308 1.00 70.87  ? 133 LEU A N     1 
ATOM 1417 C CA    . LEU D 2 121 ? 191.719 226.714 212.365 1.00 70.87  ? 133 LEU A CA    1 
ATOM 1418 C C     . LEU D 2 121 ? 192.640 227.288 213.433 1.00 70.87  ? 133 LEU A C     1 
ATOM 1419 O O     . LEU D 2 121 ? 192.390 227.133 214.633 1.00 70.87  ? 133 LEU A O     1 
ATOM 1420 C CB    . LEU D 2 121 ? 192.316 225.438 211.771 1.00 70.87  ? 133 LEU A CB    1 
ATOM 1421 C CG    . LEU D 2 121 ? 191.508 224.784 210.652 1.00 70.87  ? 133 LEU A CG    1 
ATOM 1422 C CD1   . LEU D 2 121 ? 192.195 223.521 210.159 1.00 70.87  ? 133 LEU A CD1   1 
ATOM 1423 C CD2   . LEU D 2 121 ? 190.106 224.481 211.133 1.00 70.87  ? 133 LEU A CD2   1 
ATOM 1424 N N     . THR D 2 122 ? 193.712 227.962 213.010 1.00 70.84  ? 134 THR A N     1 
ATOM 1425 C CA    . THR D 2 122 ? 194.626 228.575 213.969 1.00 70.84  ? 134 THR A CA    1 
ATOM 1426 C C     . THR D 2 122 ? 193.929 229.666 214.772 1.00 70.84  ? 134 THR A C     1 
ATOM 1427 O O     . THR D 2 122 ? 194.167 229.809 215.975 1.00 70.84  ? 134 THR A O     1 
ATOM 1428 C CB    . THR D 2 122 ? 195.851 229.135 213.246 1.00 70.84  ? 134 THR A CB    1 
ATOM 1429 O OG1   . THR D 2 122 ? 196.406 228.127 212.393 1.00 70.84  ? 134 THR A OG1   1 
ATOM 1430 C CG2   . THR D 2 122 ? 196.907 229.573 214.248 1.00 70.84  ? 134 THR A CG2   1 
ATOM 1431 N N     . HIS D 2 123 ? 193.066 230.448 214.120 1.00 72.05  ? 135 HIS A N     1 
ATOM 1432 C CA    . HIS D 2 123 ? 192.321 231.487 214.825 1.00 72.05  ? 135 HIS A CA    1 
ATOM 1433 C C     . HIS D 2 123 ? 191.407 230.885 215.886 1.00 72.05  ? 135 HIS A C     1 
ATOM 1434 O O     . HIS D 2 123 ? 191.329 231.388 217.015 1.00 72.05  ? 135 HIS A O     1 
ATOM 1435 C CB    . HIS D 2 123 ? 191.519 232.310 213.817 1.00 72.05  ? 135 HIS A CB    1 
ATOM 1436 C CG    . HIS D 2 123 ? 190.835 233.501 214.408 1.00 72.05  ? 135 HIS A CG    1 
ATOM 1437 N ND1   . HIS D 2 123 ? 191.384 234.764 214.378 1.00 72.05  ? 135 HIS A ND1   1 
ATOM 1438 C CD2   . HIS D 2 123 ? 189.640 233.624 215.034 1.00 72.05  ? 135 HIS A CD2   1 
ATOM 1439 C CE1   . HIS D 2 123 ? 190.560 235.614 214.964 1.00 72.05  ? 135 HIS A CE1   1 
ATOM 1440 N NE2   . HIS D 2 123 ? 189.495 234.948 215.371 1.00 72.05  ? 135 HIS A NE2   1 
ATOM 1441 N N     . MET D 2 124 ? 190.718 229.794 215.544 1.00 71.88  ? 136 MET A N     1 
ATOM 1442 C CA    . MET D 2 124 ? 189.863 229.117 216.514 1.00 71.88  ? 136 MET A CA    1 
ATOM 1443 C C     . MET D 2 124 ? 190.679 228.550 217.672 1.00 71.88  ? 136 MET A C     1 
ATOM 1444 O O     . MET D 2 124 ? 190.266 228.635 218.836 1.00 71.88  ? 136 MET A O     1 
ATOM 1445 C CB    . MET D 2 124 ? 189.070 228.013 215.817 1.00 71.88  ? 136 MET A CB    1 
ATOM 1446 C CG    . MET D 2 124 ? 187.955 228.530 214.922 1.00 71.88  ? 136 MET A CG    1 
ATOM 1447 S SD    . MET D 2 124 ? 187.140 227.228 213.980 1.00 71.88  ? 136 MET A SD    1 
ATOM 1448 C CE    . MET D 2 124 ? 187.548 225.791 214.962 1.00 71.88  ? 136 MET A CE    1 
ATOM 1449 N N     . MET D 2 125 ? 191.841 227.965 217.369 1.00 69.95  ? 137 MET A N     1 
ATOM 1450 C CA    . MET D 2 125 ? 192.709 227.447 218.424 1.00 69.95  ? 137 MET A CA    1 
ATOM 1451 C C     . MET D 2 125 ? 193.187 228.560 219.346 1.00 69.95  ? 137 MET A C     1 
ATOM 1452 O O     . MET D 2 125 ? 193.262 228.374 220.565 1.00 69.95  ? 137 MET A O     1 
ATOM 1453 C CB    . MET D 2 125 ? 193.901 226.709 217.814 1.00 69.95  ? 137 MET A CB    1 
ATOM 1454 C CG    . MET D 2 125 ? 193.523 225.503 216.981 1.00 69.95  ? 137 MET A CG    1 
ATOM 1455 S SD    . MET D 2 125 ? 194.879 224.903 215.960 1.00 69.95  ? 137 MET A SD    1 
ATOM 1456 C CE    . MET D 2 125 ? 196.221 224.941 217.138 1.00 69.95  ? 137 MET A CE    1 
ATOM 1457 N N     . ILE D 2 126 ? 193.531 229.719 218.783 1.00 69.17  ? 138 ILE A N     1 
ATOM 1458 C CA    . ILE D 2 126 ? 193.984 230.834 219.608 1.00 69.17  ? 138 ILE A CA    1 
ATOM 1459 C C     . ILE D 2 126 ? 192.845 231.350 220.476 1.00 69.17  ? 138 ILE A C     1 
ATOM 1460 O O     . ILE D 2 126 ? 193.054 231.731 221.633 1.00 69.17  ? 138 ILE A O     1 
ATOM 1461 C CB    . ILE D 2 126 ? 194.587 231.946 218.730 1.00 69.17  ? 138 ILE A CB    1 
ATOM 1462 C CG1   . ILE D 2 126 ? 195.857 231.449 218.040 1.00 69.17  ? 138 ILE A CG1   1 
ATOM 1463 C CG2   . ILE D 2 126 ? 194.923 233.167 219.566 1.00 69.17  ? 138 ILE A CG2   1 
ATOM 1464 C CD1   . ILE D 2 126 ? 196.253 232.265 216.831 1.00 69.17  ? 138 ILE A CD1   1 
ATOM 1465 N N     . TRP D 2 127 ? 191.622 231.369 219.940 1.00 67.89  ? 139 TRP A N     1 
ATOM 1466 C CA    . TRP D 2 127 ? 190.472 231.752 220.756 1.00 67.89  ? 139 TRP A CA    1 
ATOM 1467 C C     . TRP D 2 127 ? 190.273 230.782 221.917 1.00 67.89  ? 139 TRP A C     1 
ATOM 1468 O O     . TRP D 2 127 ? 190.033 231.202 223.058 1.00 67.89  ? 139 TRP A O     1 
ATOM 1469 C CB    . TRP D 2 127 ? 189.217 231.824 219.885 1.00 67.89  ? 139 TRP A CB    1 
ATOM 1470 C CG    . TRP D 2 127 ? 187.966 231.343 220.559 1.00 67.89  ? 139 TRP A CG    1 
ATOM 1471 C CD1   . TRP D 2 127 ? 187.275 230.201 220.280 1.00 67.89  ? 139 TRP A CD1   1 
ATOM 1472 C CD2   . TRP D 2 127 ? 187.247 231.999 221.611 1.00 67.89  ? 139 TRP A CD2   1 
ATOM 1473 N NE1   . TRP D 2 127 ? 186.176 230.099 221.098 1.00 67.89  ? 139 TRP A NE1   1 
ATOM 1474 C CE2   . TRP D 2 127 ? 186.136 231.191 221.924 1.00 67.89  ? 139 TRP A CE2   1 
ATOM 1475 C CE3   . TRP D 2 127 ? 187.438 233.188 222.321 1.00 67.89  ? 139 TRP A CE3   1 
ATOM 1476 C CZ2   . TRP D 2 127 ? 185.221 231.535 222.915 1.00 67.89  ? 139 TRP A CZ2   1 
ATOM 1477 C CZ3   . TRP D 2 127 ? 186.527 233.526 223.304 1.00 67.89  ? 139 TRP A CZ3   1 
ATOM 1478 C CH2   . TRP D 2 127 ? 185.433 232.703 223.592 1.00 67.89  ? 139 TRP A CH2   1 
ATOM 1479 N N     . HIS D 2 128 ? 190.388 229.479 221.647 1.00 71.71  ? 140 HIS A N     1 
ATOM 1480 C CA    . HIS D 2 128 ? 190.264 228.489 222.713 1.00 71.71  ? 140 HIS A CA    1 
ATOM 1481 C C     . HIS D 2 128 ? 191.360 228.660 223.757 1.00 71.71  ? 140 HIS A C     1 
ATOM 1482 O O     . HIS D 2 128 ? 191.104 228.556 224.963 1.00 71.71  ? 140 HIS A O     1 
ATOM 1483 C CB    . HIS D 2 128 ? 190.306 227.077 222.129 1.00 71.71  ? 140 HIS A CB    1 
ATOM 1484 C CG    . HIS D 2 128 ? 188.991 226.603 221.595 1.00 71.71  ? 140 HIS A CG    1 
ATOM 1485 N ND1   . HIS D 2 128 ? 188.868 225.463 220.830 1.00 71.71  ? 140 HIS A ND1   1 
ATOM 1486 C CD2   . HIS D 2 128 ? 187.743 227.114 221.712 1.00 71.71  ? 140 HIS A CD2   1 
ATOM 1487 C CE1   . HIS D 2 128 ? 187.600 225.291 220.501 1.00 71.71  ? 140 HIS A CE1   1 
ATOM 1488 N NE2   . HIS D 2 128 ? 186.897 226.280 221.022 1.00 71.71  ? 140 HIS A NE2   1 
ATOM 1489 N N     . SER D 2 129 ? 192.592 228.914 223.311 1.00 70.21  ? 141 SER A N     1 
ATOM 1490 C CA    . SER D 2 129 ? 193.701 229.096 224.240 1.00 70.21  ? 141 SER A CA    1 
ATOM 1491 C C     . SER D 2 129 ? 193.514 230.344 225.092 1.00 70.21  ? 141 SER A C     1 
ATOM 1492 O O     . SER D 2 129 ? 193.819 230.334 226.289 1.00 70.21  ? 141 SER A O     1 
ATOM 1493 C CB    . SER D 2 129 ? 195.021 229.164 223.476 1.00 70.21  ? 141 SER A CB    1 
ATOM 1494 O OG    . SER D 2 129 ? 195.959 229.968 224.167 1.00 70.21  ? 141 SER A OG    1 
ATOM 1495 N N     . ASN D 2 130 ? 193.031 231.433 224.491 1.00 70.40  ? 142 ASN A N     1 
ATOM 1496 C CA    . ASN D 2 130 ? 192.760 232.643 225.261 1.00 70.40  ? 142 ASN A CA    1 
ATOM 1497 C C     . ASN D 2 130 ? 191.670 232.399 226.294 1.00 70.40  ? 142 ASN A C     1 
ATOM 1498 O O     . ASN D 2 130 ? 191.768 232.871 227.434 1.00 70.40  ? 142 ASN A O     1 
ATOM 1499 C CB    . ASN D 2 130 ? 192.369 233.786 224.326 1.00 70.40  ? 142 ASN A CB    1 
ATOM 1500 C CG    . ASN D 2 130 ? 193.561 234.385 223.608 1.00 70.40  ? 142 ASN A CG    1 
ATOM 1501 O OD1   . ASN D 2 130 ? 194.702 234.230 224.041 1.00 70.40  ? 142 ASN A OD1   1 
ATOM 1502 N ND2   . ASN D 2 130 ? 193.301 235.077 222.507 1.00 70.40  ? 142 ASN A ND2   1 
ATOM 1503 N N     . LEU D 2 131 ? 190.624 231.660 225.916 1.00 68.44  ? 143 LEU A N     1 
ATOM 1504 C CA    . LEU D 2 131 ? 189.581 231.316 226.877 1.00 68.44  ? 143 LEU A CA    1 
ATOM 1505 C C     . LEU D 2 131 ? 190.139 230.485 228.027 1.00 68.44  ? 143 LEU A C     1 
ATOM 1506 O O     . LEU D 2 131 ? 189.828 230.740 229.198 1.00 68.44  ? 143 LEU A O     1 
ATOM 1507 C CB    . LEU D 2 131 ? 188.452 230.567 226.171 1.00 68.44  ? 143 LEU A CB    1 
ATOM 1508 C CG    . LEU D 2 131 ? 187.271 230.122 227.032 1.00 68.44  ? 143 LEU A CG    1 
ATOM 1509 C CD1   . LEU D 2 131 ? 186.705 231.295 227.814 1.00 68.44  ? 143 LEU A CD1   1 
ATOM 1510 C CD2   . LEU D 2 131 ? 186.203 229.487 226.160 1.00 68.44  ? 143 LEU A CD2   1 
ATOM 1511 N N     . ASN D 2 132 ? 190.973 229.492 227.712 1.00 68.41  ? 144 ASN A N     1 
ATOM 1512 C CA    . ASN D 2 132 ? 191.559 228.655 228.755 1.00 68.41  ? 144 ASN A CA    1 
ATOM 1513 C C     . ASN D 2 132 ? 192.459 229.468 229.677 1.00 68.41  ? 144 ASN A C     1 
ATOM 1514 O O     . ASN D 2 132 ? 192.446 229.276 230.898 1.00 68.41  ? 144 ASN A O     1 
ATOM 1515 C CB    . ASN D 2 132 ? 192.340 227.503 228.125 1.00 68.41  ? 144 ASN A CB    1 
ATOM 1516 C CG    . ASN D 2 132 ? 191.512 226.244 227.994 1.00 68.41  ? 144 ASN A CG    1 
ATOM 1517 O OD1   . ASN D 2 132 ? 190.282 226.294 227.988 1.00 68.41  ? 144 ASN A OD1   1 
ATOM 1518 N ND2   . ASN D 2 132 ? 192.182 225.103 227.887 1.00 68.41  ? 144 ASN A ND2   1 
ATOM 1519 N N     . ASP D 2 133 ? 193.254 230.376 229.109 1.00 70.83  ? 145 ASP A N     1 
ATOM 1520 C CA    . ASP D 2 133 ? 194.132 231.212 229.922 1.00 70.83  ? 145 ASP A CA    1 
ATOM 1521 C C     . ASP D 2 133 ? 193.332 232.144 230.821 1.00 70.83  ? 145 ASP A C     1 
ATOM 1522 O O     . ASP D 2 133 ? 193.686 232.343 231.989 1.00 70.83  ? 145 ASP A O     1 
ATOM 1523 C CB    . ASP D 2 133 ? 195.074 232.010 229.023 1.00 70.83  ? 145 ASP A CB    1 
ATOM 1524 C CG    . ASP D 2 133 ? 196.077 231.130 228.306 1.00 70.83  ? 145 ASP A CG    1 
ATOM 1525 O OD1   . ASP D 2 133 ? 196.433 230.067 228.855 1.00 70.83  ? 145 ASP A OD1   1 
ATOM 1526 O OD2   . ASP D 2 133 ? 196.508 231.500 227.194 1.00 70.83  ? 145 ASP A OD2   1 
ATOM 1527 N N     . ALA D 2 134 ? 192.253 232.727 230.299 1.00 67.40  ? 146 ALA A N     1 
ATOM 1528 C CA    . ALA D 2 134 ? 191.426 233.623 231.093 1.00 67.40  ? 146 ALA A CA    1 
ATOM 1529 C C     . ALA D 2 134 ? 190.556 232.893 232.105 1.00 67.40  ? 146 ALA A C     1 
ATOM 1530 O O     . ALA D 2 134 ? 190.062 233.529 233.042 1.00 67.40  ? 146 ALA A O     1 
ATOM 1531 C CB    . ALA D 2 134 ? 190.540 234.471 230.176 1.00 67.40  ? 146 ALA A CB    1 
ATOM 1532 N N     . THR D 2 135 ? 190.356 231.585 231.948 1.00 65.04  ? 147 THR A N     1 
ATOM 1533 C CA    . THR D 2 135 ? 189.488 230.830 232.843 1.00 65.04  ? 147 THR A CA    1 
ATOM 1534 C C     . THR D 2 135 ? 190.254 230.079 233.927 1.00 65.04  ? 147 THR A C     1 
ATOM 1535 O O     . THR D 2 135 ? 189.954 230.234 235.114 1.00 65.04  ? 147 THR A O     1 
ATOM 1536 C CB    . THR D 2 135 ? 188.633 229.844 232.038 1.00 65.04  ? 147 THR A CB    1 
ATOM 1537 O OG1   . THR D 2 135 ? 187.856 230.561 231.073 1.00 65.04  ? 147 THR A OG1   1 
ATOM 1538 C CG2   . THR D 2 135 ? 187.700 229.080 232.958 1.00 65.04  ? 147 THR A CG2   1 
ATOM 1539 N N     . TYR D 2 136 ? 191.243 229.272 233.550 1.00 64.25  ? 148 TYR A N     1 
ATOM 1540 C CA    . TYR D 2 136 ? 191.911 228.372 234.477 1.00 64.25  ? 148 TYR A CA    1 
ATOM 1541 C C     . TYR D 2 136 ? 193.379 228.745 234.637 1.00 64.25  ? 148 TYR A C     1 
ATOM 1542 O O     . TYR D 2 136 ? 193.986 229.353 233.750 1.00 64.25  ? 148 TYR A O     1 
ATOM 1543 C CB    . TYR D 2 136 ? 191.810 226.916 234.005 1.00 64.25  ? 148 TYR A CB    1 
ATOM 1544 C CG    . TYR D 2 136 ? 190.396 226.416 233.824 1.00 64.25  ? 148 TYR A CG    1 
ATOM 1545 C CD1   . TYR D 2 136 ? 189.491 226.435 234.876 1.00 64.25  ? 148 TYR A CD1   1 
ATOM 1546 C CD2   . TYR D 2 136 ? 189.968 225.916 232.602 1.00 64.25  ? 148 TYR A CD2   1 
ATOM 1547 C CE1   . TYR D 2 136 ? 188.198 225.975 234.714 1.00 64.25  ? 148 TYR A CE1   1 
ATOM 1548 C CE2   . TYR D 2 136 ? 188.677 225.454 232.431 1.00 64.25  ? 148 TYR A CE2   1 
ATOM 1549 C CZ    . TYR D 2 136 ? 187.797 225.486 233.490 1.00 64.25  ? 148 TYR A CZ    1 
ATOM 1550 O OH    . TYR D 2 136 ? 186.512 225.027 233.323 1.00 64.25  ? 148 TYR A OH    1 
ATOM 1551 N N     . GLN D 2 137 ? 193.941 228.372 235.784 1.00 65.78  ? 149 GLN A N     1 
ATOM 1552 C CA    . GLN D 2 137 ? 195.367 228.500 236.054 1.00 65.78  ? 149 GLN A CA    1 
ATOM 1553 C C     . GLN D 2 137 ? 196.004 227.120 235.995 1.00 65.78  ? 149 GLN A C     1 
ATOM 1554 O O     . GLN D 2 137 ? 195.569 226.204 236.700 1.00 65.78  ? 149 GLN A O     1 
ATOM 1555 C CB    . GLN D 2 137 ? 195.626 229.114 237.431 1.00 65.78  ? 149 GLN A CB    1 
ATOM 1556 C CG    . GLN D 2 137 ? 195.084 230.511 237.646 1.00 65.78  ? 149 GLN A CG    1 
ATOM 1557 C CD    . GLN D 2 137 ? 195.529 231.087 238.976 1.00 65.78  ? 149 GLN A CD    1 
ATOM 1558 O OE1   . GLN D 2 137 ? 196.529 230.653 239.546 1.00 65.78  ? 149 GLN A OE1   1 
ATOM 1559 N NE2   . GLN D 2 137 ? 194.774 232.047 239.491 1.00 65.78  ? 149 GLN A NE2   1 
ATOM 1560 N N     . ARG D 2 138 ? 197.028 226.972 235.164 1.00 73.88  ? 150 ARG A N     1 
ATOM 1561 C CA    . ARG D 2 138 ? 197.782 225.720 235.102 1.00 73.88  ? 150 ARG A CA    1 
ATOM 1562 C C     . ARG D 2 138 ? 199.055 225.820 235.940 1.00 73.88  ? 150 ARG A C     1 
ATOM 1563 O O     . ARG D 2 138 ? 200.178 225.756 235.441 1.00 73.88  ? 150 ARG A O     1 
ATOM 1564 C CB    . ARG D 2 138 ? 198.094 225.354 233.656 1.00 73.88  ? 150 ARG A CB    1 
ATOM 1565 C CG    . ARG D 2 138 ? 198.261 226.533 232.725 1.00 73.88  ? 150 ARG A CG    1 
ATOM 1566 C CD    . ARG D 2 138 ? 198.109 226.083 231.286 1.00 73.88  ? 150 ARG A CD    1 
ATOM 1567 N NE    . ARG D 2 138 ? 199.245 225.278 230.853 1.00 73.88  ? 150 ARG A NE    1 
ATOM 1568 C CZ    . ARG D 2 138 ? 199.228 223.958 230.736 1.00 73.88  ? 150 ARG A CZ    1 
ATOM 1569 N NH1   . ARG D 2 138 ? 198.143 223.253 231.013 1.00 73.88  ? 150 ARG A NH1   1 
ATOM 1570 N NH2   . ARG D 2 138 ? 200.327 223.328 230.333 1.00 73.88  ? 150 ARG A NH2   1 
ATOM 1571 N N     . THR D 2 139 ? 198.856 225.983 237.249 1.00 76.45  ? 151 THR A N     1 
ATOM 1572 C CA    . THR D 2 139 ? 199.989 225.996 238.166 1.00 76.45  ? 151 THR A CA    1 
ATOM 1573 C C     . THR D 2 139 ? 200.547 224.596 238.385 1.00 76.45  ? 151 THR A C     1 
ATOM 1574 O O     . THR D 2 139 ? 201.722 224.447 238.738 1.00 76.45  ? 151 THR A O     1 
ATOM 1575 C CB    . THR D 2 139 ? 199.579 226.620 239.500 1.00 76.45  ? 151 THR A CB    1 
ATOM 1576 O OG1   . THR D 2 139 ? 200.736 226.789 240.323 1.00 76.45  ? 151 THR A OG1   1 
ATOM 1577 C CG2   . THR D 2 139 ? 198.589 225.730 240.222 1.00 76.45  ? 151 THR A CG2   1 
ATOM 1578 N N     . ARG D 2 140 ? 199.722 223.563 238.188 1.00 75.76  ? 152 ARG A N     1 
ATOM 1579 C CA    . ARG D 2 140 ? 200.197 222.194 238.352 1.00 75.76  ? 152 ARG A CA    1 
ATOM 1580 C C     . ARG D 2 140 ? 201.254 221.852 237.312 1.00 75.76  ? 152 ARG A C     1 
ATOM 1581 O O     . ARG D 2 140 ? 202.272 221.228 237.633 1.00 75.76  ? 152 ARG A O     1 
ATOM 1582 C CB    . ARG D 2 140 ? 199.021 221.221 238.272 1.00 75.76  ? 152 ARG A CB    1 
ATOM 1583 C CG    . ARG D 2 140 ? 197.741 221.766 238.882 1.00 75.76  ? 152 ARG A CG    1 
ATOM 1584 C CD    . ARG D 2 140 ? 196.891 220.660 239.478 1.00 75.76  ? 152 ARG A CD    1 
ATOM 1585 N NE    . ARG D 2 140 ? 196.264 219.839 238.450 1.00 75.76  ? 152 ARG A NE    1 
ATOM 1586 C CZ    . ARG D 2 140 ? 195.286 218.974 238.679 1.00 75.76  ? 152 ARG A CZ    1 
ATOM 1587 N NH1   . ARG D 2 140 ? 194.796 218.791 239.893 1.00 75.76  ? 152 ARG A NH1   1 
ATOM 1588 N NH2   . ARG D 2 140 ? 194.788 218.275 237.663 1.00 75.76  ? 152 ARG A NH2   1 
ATOM 1589 N N     . ALA D 2 141 ? 201.033 222.255 236.059 1.00 79.21  ? 153 ALA A N     1 
ATOM 1590 C CA    . ALA D 2 141 ? 202.041 222.042 235.028 1.00 79.21  ? 153 ALA A CA    1 
ATOM 1591 C C     . ALA D 2 141 ? 203.304 222.843 235.309 1.00 79.21  ? 153 ALA A C     1 
ATOM 1592 O O     . ALA D 2 141 ? 204.410 222.381 235.005 1.00 79.21  ? 153 ALA A O     1 
ATOM 1593 C CB    . ALA D 2 141 ? 201.476 222.403 233.655 1.00 79.21  ? 153 ALA A CB    1 
ATOM 1594 N N     . LEU D 2 142 ? 203.160 224.042 235.875 1.00 81.32  ? 154 LEU A N     1 
ATOM 1595 C CA    . LEU D 2 142 ? 204.326 224.842 236.234 1.00 81.32  ? 154 LEU A CA    1 
ATOM 1596 C C     . LEU D 2 142 ? 205.161 224.142 237.298 1.00 81.32  ? 154 LEU A C     1 
ATOM 1597 O O     . LEU D 2 142 ? 206.369 223.946 237.130 1.00 81.32  ? 154 LEU A O     1 
ATOM 1598 C CB    . LEU D 2 142 ? 203.877 226.220 236.722 1.00 81.32  ? 154 LEU A CB    1 
ATOM 1599 C CG    . LEU D 2 142 ? 203.554 227.271 235.659 1.00 81.32  ? 154 LEU A CG    1 
ATOM 1600 C CD1   . LEU D 2 142 ? 202.733 228.397 236.263 1.00 81.32  ? 154 LEU A CD1   1 
ATOM 1601 C CD2   . LEU D 2 142 ? 204.824 227.815 235.034 1.00 81.32  ? 154 LEU A CD2   1 
ATOM 1602 N N     . VAL D 2 143 ? 204.525 223.738 238.399 1.00 82.75  ? 155 VAL A N     1 
ATOM 1603 C CA    . VAL D 2 143 ? 205.251 223.081 239.481 1.00 82.75  ? 155 VAL A CA    1 
ATOM 1604 C C     . VAL D 2 143 ? 205.814 221.730 239.058 1.00 82.75  ? 155 VAL A C     1 
ATOM 1605 O O     . VAL D 2 143 ? 206.916 221.364 239.487 1.00 82.75  ? 155 VAL A O     1 
ATOM 1606 C CB    . VAL D 2 143 ? 204.341 222.923 240.712 1.00 82.75  ? 155 VAL A CB    1 
ATOM 1607 C CG1   . VAL D 2 143 ? 205.070 222.201 241.835 1.00 82.75  ? 155 VAL A CG1   1 
ATOM 1608 C CG2   . VAL D 2 143 ? 203.850 224.281 241.183 1.00 82.75  ? 155 VAL A CG2   1 
ATOM 1609 N N     . ARG D 2 144 ? 205.095 220.986 238.214 1.00 82.49  ? 156 ARG A N     1 
ATOM 1610 C CA    . ARG D 2 144 ? 205.547 219.657 237.815 1.00 82.49  ? 156 ARG A CA    1 
ATOM 1611 C C     . ARG D 2 144 ? 206.863 219.719 237.049 1.00 82.49  ? 156 ARG A C     1 
ATOM 1612 O O     . ARG D 2 144 ? 207.753 218.887 237.262 1.00 82.49  ? 156 ARG A O     1 
ATOM 1613 C CB    . ARG D 2 144 ? 204.470 218.978 236.970 1.00 82.49  ? 156 ARG A CB    1 
ATOM 1614 C CG    . ARG D 2 144 ? 204.652 217.484 236.803 1.00 82.49  ? 156 ARG A CG    1 
ATOM 1615 C CD    . ARG D 2 144 ? 203.349 216.755 237.072 1.00 82.49  ? 156 ARG A CD    1 
ATOM 1616 N NE    . ARG D 2 144 ? 202.353 217.045 236.049 1.00 82.49  ? 156 ARG A NE    1 
ATOM 1617 C CZ    . ARG D 2 144 ? 201.130 216.533 236.027 1.00 82.49  ? 156 ARG A CZ    1 
ATOM 1618 N NH1   . ARG D 2 144 ? 200.715 215.696 236.963 1.00 82.49  ? 156 ARG A NH1   1 
ATOM 1619 N NH2   . ARG D 2 144 ? 200.304 216.869 235.041 1.00 82.49  ? 156 ARG A NH2   1 
ATOM 1620 N N     . THR D 2 145 ? 207.007 220.693 236.156 1.00 86.43  ? 157 THR A N     1 
ATOM 1621 C CA    . THR D 2 145 ? 208.190 220.806 235.314 1.00 86.43  ? 157 THR A CA    1 
ATOM 1622 C C     . THR D 2 145 ? 209.364 221.476 236.015 1.00 86.43  ? 157 THR A C     1 
ATOM 1623 O O     . THR D 2 145 ? 210.460 221.523 235.447 1.00 86.43  ? 157 THR A O     1 
ATOM 1624 C CB    . THR D 2 145 ? 207.857 221.574 234.033 1.00 86.43  ? 157 THR A CB    1 
ATOM 1625 O OG1   . THR D 2 145 ? 207.046 222.712 234.354 1.00 86.43  ? 157 THR A OG1   1 
ATOM 1626 C CG2   . THR D 2 145 ? 207.109 220.681 233.059 1.00 86.43  ? 157 THR A CG2   1 
ATOM 1627 N N     . GLY D 2 146 ? 209.169 221.992 237.226 1.00 86.31  ? 158 GLY A N     1 
ATOM 1628 C CA    . GLY D 2 146 ? 210.233 222.579 238.009 1.00 86.31  ? 158 GLY A CA    1 
ATOM 1629 C C     . GLY D 2 146 ? 210.179 224.087 238.128 1.00 86.31  ? 158 GLY A C     1 
ATOM 1630 O O     . GLY D 2 146 ? 210.763 224.637 239.072 1.00 86.31  ? 158 GLY A O     1 
ATOM 1631 N N     . MET D 2 147 ? 209.505 224.774 237.210 1.00 89.07  ? 159 MET A N     1 
ATOM 1632 C CA    . MET D 2 147 ? 209.370 226.217 237.336 1.00 89.07  ? 159 MET A CA    1 
ATOM 1633 C C     . MET D 2 147 ? 208.471 226.552 238.519 1.00 89.07  ? 159 MET A C     1 
ATOM 1634 O O     . MET D 2 147 ? 207.525 225.825 238.833 1.00 89.07  ? 159 MET A O     1 
ATOM 1635 C CB    . MET D 2 147 ? 208.792 226.833 236.063 1.00 89.07  ? 159 MET A CB    1 
ATOM 1636 C CG    . MET D 2 147 ? 207.836 225.936 235.309 1.00 89.07  ? 159 MET A CG    1 
ATOM 1637 S SD    . MET D 2 147 ? 207.927 226.128 233.524 1.00 89.07  ? 159 MET A SD    1 
ATOM 1638 C CE    . MET D 2 147 ? 209.170 224.907 233.142 1.00 89.07  ? 159 MET A CE    1 
ATOM 1639 N N     . ASP D 2 148 ? 208.774 227.657 239.178 1.00 93.67  ? 160 ASP A N     1 
ATOM 1640 C CA    . ASP D 2 148 ? 207.952 228.000 240.328 1.00 93.67  ? 160 ASP A CA    1 
ATOM 1641 C C     . ASP D 2 148 ? 206.559 228.442 239.879 1.00 93.67  ? 160 ASP A C     1 
ATOM 1642 O O     . ASP D 2 148 ? 206.396 228.964 238.773 1.00 93.67  ? 160 ASP A O     1 
ATOM 1643 C CB    . ASP D 2 148 ? 208.621 229.094 241.168 1.00 93.67  ? 160 ASP A CB    1 
ATOM 1644 C CG    . ASP D 2 148 ? 208.885 230.372 240.387 1.00 93.67  ? 160 ASP A CG    1 
ATOM 1645 O OD1   . ASP D 2 148 ? 208.579 230.430 239.180 1.00 93.67  ? 160 ASP A OD1   1 
ATOM 1646 O OD2   . ASP D 2 148 ? 209.408 231.331 240.992 1.00 93.67  ? 160 ASP A OD2   1 
ATOM 1647 N N     . PRO D 2 149 ? 205.533 228.218 240.706 1.00 94.20  ? 161 PRO A N     1 
ATOM 1648 C CA    . PRO D 2 149 ? 204.197 228.742 240.392 1.00 94.20  ? 161 PRO A CA    1 
ATOM 1649 C C     . PRO D 2 149 ? 204.097 230.248 240.524 1.00 94.20  ? 161 PRO A C     1 
ATOM 1650 O O     . PRO D 2 149 ? 203.009 230.804 240.333 1.00 94.20  ? 161 PRO A O     1 
ATOM 1651 C CB    . PRO D 2 149 ? 203.303 228.046 241.426 1.00 94.20  ? 161 PRO A CB    1 
ATOM 1652 C CG    . PRO D 2 149 ? 204.212 227.760 242.568 1.00 94.20  ? 161 PRO A CG    1 
ATOM 1653 C CD    . PRO D 2 149 ? 205.544 227.439 241.956 1.00 94.20  ? 161 PRO A CD    1 
ATOM 1654 N N     . ARG D 2 150 ? 205.204 230.914 240.849 1.00 96.70  ? 162 ARG A N     1 
ATOM 1655 C CA    . ARG D 2 150 ? 205.162 232.330 241.184 1.00 96.70  ? 162 ARG A CA    1 
ATOM 1656 C C     . ARG D 2 150 ? 204.791 233.178 239.971 1.00 96.70  ? 162 ARG A C     1 
ATOM 1657 O O     . ARG D 2 150 ? 204.077 234.178 240.100 1.00 96.70  ? 162 ARG A O     1 
ATOM 1658 C CB    . ARG D 2 150 ? 206.515 232.748 241.762 1.00 96.70  ? 162 ARG A CB    1 
ATOM 1659 C CG    . ARG D 2 150 ? 206.533 234.119 242.384 1.00 96.70  ? 162 ARG A CG    1 
ATOM 1660 C CD    . ARG D 2 150 ? 207.912 234.485 242.908 1.00 96.70  ? 162 ARG A CD    1 
ATOM 1661 N NE    . ARG D 2 150 ? 208.351 233.608 243.985 1.00 96.70  ? 162 ARG A NE    1 
ATOM 1662 C CZ    . ARG D 2 150 ? 209.557 233.648 244.535 1.00 96.70  ? 162 ARG A CZ    1 
ATOM 1663 N NH1   . ARG D 2 150 ? 210.473 234.511 244.129 1.00 96.70  ? 162 ARG A NH1   1 
ATOM 1664 N NH2   . ARG D 2 150 ? 209.851 232.801 245.518 1.00 96.70  ? 162 ARG A NH2   1 
ATOM 1665 N N     . MET D 2 151 ? 205.259 232.793 238.782 1.00 90.11  ? 163 MET A N     1 
ATOM 1666 C CA    . MET D 2 151 ? 205.040 233.573 237.562 1.00 90.11  ? 163 MET A CA    1 
ATOM 1667 C C     . MET D 2 151 ? 203.930 232.915 236.744 1.00 90.11  ? 163 MET A C     1 
ATOM 1668 O O     . MET D 2 151 ? 203.933 231.707 236.504 1.00 90.11  ? 163 MET A O     1 
ATOM 1669 C CB    . MET D 2 151 ? 206.333 233.712 236.760 1.00 90.11  ? 163 MET A CB    1 
ATOM 1670 C CG    . MET D 2 151 ? 206.842 232.438 236.097 1.00 90.11  ? 163 MET A CG    1 
ATOM 1671 S SD    . MET D 2 151 ? 208.641 232.329 236.062 1.00 90.11  ? 163 MET A SD    1 
ATOM 1672 C CE    . MET D 2 151 ? 208.871 230.555 235.994 1.00 90.11  ? 163 MET A CE    1 
ATOM 1673 N N     . CYS D 2 152 ? 202.952 233.724 236.340 1.00 81.13  ? 164 CYS A N     1 
ATOM 1674 C CA    . CYS D 2 152 ? 201.876 233.276 235.465 1.00 81.13  ? 164 CYS A CA    1 
ATOM 1675 C C     . CYS D 2 152 ? 201.624 234.216 234.293 1.00 81.13  ? 164 CYS A C     1 
ATOM 1676 O O     . CYS D 2 152 ? 200.822 233.882 233.416 1.00 81.13  ? 164 CYS A O     1 
ATOM 1677 C CB    . CYS D 2 152 ? 200.578 233.105 236.262 1.00 81.13  ? 164 CYS A CB    1 
ATOM 1678 S SG    . CYS D 2 152 ? 200.383 231.487 237.040 1.00 81.13  ? 164 CYS A SG    1 
ATOM 1679 N N     . SER D 2 153 ? 202.280 235.380 234.258 1.00 78.53  ? 165 SER A N     1 
ATOM 1680 C CA    . SER D 2 153 ? 202.078 236.313 233.153 1.00 78.53  ? 165 SER A CA    1 
ATOM 1681 C C     . SER D 2 153 ? 202.602 235.753 231.839 1.00 78.53  ? 165 SER A C     1 
ATOM 1682 O O     . SER D 2 153 ? 202.014 236.003 230.781 1.00 78.53  ? 165 SER A O     1 
ATOM 1683 C CB    . SER D 2 153 ? 202.758 237.647 233.455 1.00 78.53  ? 165 SER A CB    1 
ATOM 1684 O OG    . SER D 2 153 ? 204.097 237.654 232.993 1.00 78.53  ? 165 SER A OG    1 
ATOM 1685 N N     . LEU D 2 154 ? 203.695 235.001 231.885 1.00 82.07  ? 166 LEU A N     1 
ATOM 1686 C CA    . LEU D 2 154 ? 204.331 234.464 230.692 1.00 82.07  ? 166 LEU A CA    1 
ATOM 1687 C C     . LEU D 2 154 ? 203.635 233.222 230.155 1.00 82.07  ? 166 LEU A C     1 
ATOM 1688 O O     . LEU D 2 154 ? 204.030 232.716 229.100 1.00 82.07  ? 166 LEU A O     1 
ATOM 1689 C CB    . LEU D 2 154 ? 205.798 234.145 230.990 1.00 82.07  ? 166 LEU A CB    1 
ATOM 1690 C CG    . LEU D 2 154 ? 206.516 235.093 231.949 1.00 82.07  ? 166 LEU A CG    1 
ATOM 1691 C CD1   . LEU D 2 154 ? 207.878 234.537 232.312 1.00 82.07  ? 166 LEU A CD1   1 
ATOM 1692 C CD2   . LEU D 2 154 ? 206.652 236.474 231.330 1.00 82.07  ? 166 LEU A CD2   1 
ATOM 1693 N N     . MET D 2 155 ? 202.611 232.725 230.846 1.00 80.73  ? 167 MET A N     1 
ATOM 1694 C CA    . MET D 2 155 ? 201.916 231.505 230.463 1.00 80.73  ? 167 MET A CA    1 
ATOM 1695 C C     . MET D 2 155 ? 200.822 231.740 229.426 1.00 80.73  ? 167 MET A C     1 
ATOM 1696 O O     . MET D 2 155 ? 199.916 230.909 229.300 1.00 80.73  ? 167 MET A O     1 
ATOM 1697 C CB    . MET D 2 155 ? 201.324 230.831 231.705 1.00 80.73  ? 167 MET A CB    1 
ATOM 1698 C CG    . MET D 2 155 ? 202.335 230.231 232.694 1.00 80.73  ? 167 MET A CG    1 
ATOM 1699 S SD    . MET D 2 155 ? 203.973 229.713 232.116 1.00 80.73  ? 167 MET A SD    1 
ATOM 1700 C CE    . MET D 2 155 ? 203.597 228.618 230.742 1.00 80.73  ? 167 MET A CE    1 
ATOM 1701 N N     . GLN D 2 156 ? 200.881 232.846 228.687 1.00 74.58  ? 168 GLN A N     1 
ATOM 1702 C CA    . GLN D 2 156 ? 199.879 233.101 227.660 1.00 74.58  ? 168 GLN A CA    1 
ATOM 1703 C C     . GLN D 2 156 ? 200.020 232.103 226.520 1.00 74.58  ? 168 GLN A C     1 
ATOM 1704 O O     . GLN D 2 156 ? 201.111 231.912 225.977 1.00 74.58  ? 168 GLN A O     1 
ATOM 1705 C CB    . GLN D 2 156 ? 200.010 234.526 227.128 1.00 74.58  ? 168 GLN A CB    1 
ATOM 1706 C CG    . GLN D 2 156 ? 198.965 234.879 226.084 1.00 74.58  ? 168 GLN A CG    1 
ATOM 1707 C CD    . GLN D 2 156 ? 199.087 236.305 225.597 1.00 74.58  ? 168 GLN A CD    1 
ATOM 1708 O OE1   . GLN D 2 156 ? 199.900 237.077 226.104 1.00 74.58  ? 168 GLN A OE1   1 
ATOM 1709 N NE2   . GLN D 2 156 ? 198.279 236.665 224.608 1.00 74.58  ? 168 GLN A NE2   1 
ATOM 1710 N N     . GLY D 2 157 ? 198.905 231.491 226.137 1.00 75.33  ? 169 GLY A N     1 
ATOM 1711 C CA    . GLY D 2 157 ? 198.923 230.487 225.087 1.00 75.33  ? 169 GLY A CA    1 
ATOM 1712 C C     . GLY D 2 157 ? 199.654 229.215 225.458 1.00 75.33  ? 169 GLY A C     1 
ATOM 1713 O O     . GLY D 2 157 ? 200.306 228.607 224.600 1.00 75.33  ? 169 GLY A O     1 
ATOM 1714 N N     . SER D 2 158 ? 199.561 228.796 226.720 1.00 74.24  ? 170 SER A N     1 
ATOM 1715 C CA    . SER D 2 158 ? 200.201 227.558 227.146 1.00 74.24  ? 170 SER A CA    1 
ATOM 1716 C C     . SER D 2 158 ? 199.414 226.326 226.720 1.00 74.24  ? 170 SER A C     1 
ATOM 1717 O O     . SER D 2 158 ? 199.972 225.224 226.686 1.00 74.24  ? 170 SER A O     1 
ATOM 1718 C CB    . SER D 2 158 ? 200.391 227.564 228.663 1.00 74.24  ? 170 SER A CB    1 
ATOM 1719 O OG    . SER D 2 158 ? 199.316 228.229 229.302 1.00 74.24  ? 170 SER A OG    1 
ATOM 1720 N N     . THR D 2 159 ? 198.134 226.486 226.398 1.00 72.45  ? 171 THR A N     1 
ATOM 1721 C CA    . THR D 2 159 ? 197.292 225.372 225.986 1.00 72.45  ? 171 THR A CA    1 
ATOM 1722 C C     . THR D 2 159 ? 197.249 225.184 224.476 1.00 72.45  ? 171 THR A C     1 
ATOM 1723 O O     . THR D 2 159 ? 196.534 224.297 223.998 1.00 72.45  ? 171 THR A O     1 
ATOM 1724 C CB    . THR D 2 159 ? 195.867 225.561 226.516 1.00 72.45  ? 171 THR A CB    1 
ATOM 1725 O OG1   . THR D 2 159 ? 195.382 226.854 226.135 1.00 72.45  ? 171 THR A OG1   1 
ATOM 1726 C CG2   . THR D 2 159 ? 195.845 225.445 228.031 1.00 72.45  ? 171 THR A CG2   1 
ATOM 1727 N N     . LEU D 2 160 ? 197.985 225.986 223.721 1.00 71.84  ? 172 LEU A N     1 
ATOM 1728 C CA    . LEU D 2 160 ? 198.001 225.852 222.269 1.00 71.84  ? 172 LEU A CA    1 
ATOM 1729 C C     . LEU D 2 160 ? 198.750 224.588 221.870 1.00 71.84  ? 172 LEU A C     1 
ATOM 1730 O O     . LEU D 2 160 ? 199.905 224.411 222.277 1.00 71.84  ? 172 LEU A O     1 
ATOM 1731 C CB    . LEU D 2 160 ? 198.652 227.072 221.629 1.00 71.84  ? 172 LEU A CB    1 
ATOM 1732 C CG    . LEU D 2 160 ? 197.717 228.202 221.200 1.00 71.84  ? 172 LEU A CG    1 
ATOM 1733 C CD1   . LEU D 2 160 ? 198.514 229.360 220.626 1.00 71.84  ? 172 LEU A CD1   1 
ATOM 1734 C CD2   . LEU D 2 160 ? 196.699 227.696 220.193 1.00 71.84  ? 172 LEU A CD2   1 
ATOM 1735 N N     . PRO D 2 161 ? 198.147 223.691 221.095 1.00 73.60  ? 173 PRO A N     1 
ATOM 1736 C CA    . PRO D 2 161 ? 198.872 222.498 220.644 1.00 73.60  ? 173 PRO A CA    1 
ATOM 1737 C C     . PRO D 2 161 ? 199.937 222.858 219.618 1.00 73.60  ? 173 PRO A C     1 
ATOM 1738 O O     . PRO D 2 161 ? 199.971 223.956 219.061 1.00 73.60  ? 173 PRO A O     1 
ATOM 1739 C CB    . PRO D 2 161 ? 197.779 221.614 220.038 1.00 73.60  ? 173 PRO A CB    1 
ATOM 1740 C CG    . PRO D 2 161 ? 196.669 222.541 219.710 1.00 73.60  ? 173 PRO A CG    1 
ATOM 1741 C CD    . PRO D 2 161 ? 196.732 223.672 220.691 1.00 73.60  ? 173 PRO A CD    1 
ATOM 1742 N N     . ARG D 2 162 ? 200.827 221.894 219.376 1.00 79.39  ? 174 ARG A N     1 
ATOM 1743 C CA    . ARG D 2 162 ? 201.949 222.116 218.472 1.00 79.39  ? 174 ARG A CA    1 
ATOM 1744 C C     . ARG D 2 162 ? 201.513 222.321 217.028 1.00 79.39  ? 174 ARG A C     1 
ATOM 1745 O O     . ARG D 2 162 ? 202.293 222.854 216.232 1.00 79.39  ? 174 ARG A O     1 
ATOM 1746 C CB    . ARG D 2 162 ? 202.927 220.943 218.547 1.00 79.39  ? 174 ARG A CB    1 
ATOM 1747 C CG    . ARG D 2 162 ? 203.666 220.825 219.871 1.00 79.39  ? 174 ARG A CG    1 
ATOM 1748 C CD    . ARG D 2 162 ? 204.656 219.650 219.898 1.00 79.39  ? 174 ARG A CD    1 
ATOM 1749 N NE    . ARG D 2 162 ? 204.053 218.322 219.803 1.00 79.39  ? 174 ARG A NE    1 
ATOM 1750 C CZ    . ARG D 2 162 ? 204.033 217.560 218.714 1.00 79.39  ? 174 ARG A CZ    1 
ATOM 1751 N NH1   . ARG D 2 162 ? 204.544 217.975 217.566 1.00 79.39  ? 174 ARG A NH1   1 
ATOM 1752 N NH2   . ARG D 2 162 ? 203.473 216.355 218.778 1.00 79.39  ? 174 ARG A NH2   1 
ATOM 1753 N N     . ARG D 2 163 ? 200.294 221.916 216.669 1.00 75.63  ? 175 ARG A N     1 
ATOM 1754 C CA    . ARG D 2 163 ? 199.853 222.030 215.285 1.00 75.63  ? 175 ARG A CA    1 
ATOM 1755 C C     . ARG D 2 163 ? 199.595 223.470 214.860 1.00 75.63  ? 175 ARG A C     1 
ATOM 1756 O O     . ARG D 2 163 ? 199.375 223.712 213.669 1.00 75.63  ? 175 ARG A O     1 
ATOM 1757 C CB    . ARG D 2 163 ? 198.599 221.184 215.057 1.00 75.63  ? 175 ARG A CB    1 
ATOM 1758 C CG    . ARG D 2 163 ? 197.402 221.582 215.899 1.00 75.63  ? 175 ARG A CG    1 
ATOM 1759 C CD    . ARG D 2 163 ? 196.124 221.006 215.313 1.00 75.63  ? 175 ARG A CD    1 
ATOM 1760 N NE    . ARG D 2 163 ? 195.244 220.460 216.339 1.00 75.63  ? 175 ARG A NE    1 
ATOM 1761 C CZ    . ARG D 2 163 ? 193.956 220.204 216.161 1.00 75.63  ? 175 ARG A CZ    1 
ATOM 1762 N NH1   . ARG D 2 163 ? 193.361 220.428 215.001 1.00 75.63  ? 175 ARG A NH1   1 
ATOM 1763 N NH2   . ARG D 2 163 ? 193.248 219.706 217.170 1.00 75.63  ? 175 ARG A NH2   1 
ATOM 1764 N N     . SER D 2 164 ? 199.609 224.420 215.791 1.00 72.40  ? 176 SER A N     1 
ATOM 1765 C CA    . SER D 2 164 ? 199.467 225.822 215.427 1.00 72.40  ? 176 SER A CA    1 
ATOM 1766 C C     . SER D 2 164 ? 200.657 226.273 214.591 1.00 72.40  ? 176 SER A C     1 
ATOM 1767 O O     . SER D 2 164 ? 201.792 225.838 214.809 1.00 72.40  ? 176 SER A O     1 
ATOM 1768 C CB    . SER D 2 164 ? 199.347 226.691 216.677 1.00 72.40  ? 176 SER A CB    1 
ATOM 1769 O OG    . SER D 2 164 ? 200.563 226.709 217.402 1.00 72.40  ? 176 SER A OG    1 
ATOM 1770 N N     . GLY D 2 165 ? 200.394 227.151 213.629 1.00 73.94  ? 177 GLY A N     1 
ATOM 1771 C CA    . GLY D 2 165 ? 201.421 227.645 212.733 1.00 73.94  ? 177 GLY A CA    1 
ATOM 1772 C C     . GLY D 2 165 ? 202.312 228.681 213.382 1.00 73.94  ? 177 GLY A C     1 
ATOM 1773 O O     . GLY D 2 165 ? 202.536 228.675 214.598 1.00 73.94  ? 177 GLY A O     1 
ATOM 1774 N N     . ALA D 2 166 ? 202.834 229.588 212.555 1.00 80.26  ? 178 ALA A N     1 
ATOM 1775 C CA    . ALA D 2 166 ? 203.695 230.645 213.072 1.00 80.26  ? 178 ALA A CA    1 
ATOM 1776 C C     . ALA D 2 166 ? 202.921 231.632 213.935 1.00 80.26  ? 178 ALA A C     1 
ATOM 1777 O O     . ALA D 2 166 ? 203.482 232.199 214.879 1.00 80.26  ? 178 ALA A O     1 
ATOM 1778 C CB    . ALA D 2 166 ? 204.384 231.373 211.918 1.00 80.26  ? 178 ALA A CB    1 
ATOM 1779 N N     . ALA D 2 167 ? 201.641 231.855 213.626 1.00 77.10  ? 179 ALA A N     1 
ATOM 1780 C CA    . ALA D 2 167 ? 200.834 232.763 214.435 1.00 77.10  ? 179 ALA A CA    1 
ATOM 1781 C C     . ALA D 2 167 ? 200.677 232.242 215.857 1.00 77.10  ? 179 ALA A C     1 
ATOM 1782 O O     . ALA D 2 167 ? 200.743 233.014 216.821 1.00 77.10  ? 179 ALA A O     1 
ATOM 1783 C CB    . ALA D 2 167 ? 199.467 232.973 213.785 1.00 77.10  ? 179 ALA A CB    1 
ATOM 1784 N N     . GLY D 2 168 ? 200.460 230.934 216.008 1.00 76.49  ? 180 GLY A N     1 
ATOM 1785 C CA    . GLY D 2 168 ? 200.352 230.362 217.341 1.00 76.49  ? 180 GLY A CA    1 
ATOM 1786 C C     . GLY D 2 168 ? 201.637 230.489 218.134 1.00 76.49  ? 180 GLY A C     1 
ATOM 1787 O O     . GLY D 2 168 ? 201.612 230.756 219.338 1.00 76.49  ? 180 GLY A O     1 
ATOM 1788 N N     . ALA D 2 169 ? 202.778 230.296 217.472 1.00 78.48  ? 181 ALA A N     1 
ATOM 1789 C CA    . ALA D 2 169 ? 204.060 230.464 218.146 1.00 78.48  ? 181 ALA A CA    1 
ATOM 1790 C C     . ALA D 2 169 ? 204.301 231.920 218.520 1.00 78.48  ? 181 ALA A C     1 
ATOM 1791 O O     . ALA D 2 169 ? 204.905 232.209 219.560 1.00 78.48  ? 181 ALA A O     1 
ATOM 1792 C CB    . ALA D 2 169 ? 205.190 229.941 217.261 1.00 78.48  ? 181 ALA A CB    1 
ATOM 1793 N N     . ALA D 2 170 ? 203.846 232.852 217.681 1.00 77.07  ? 182 ALA A N     1 
ATOM 1794 C CA    . ALA D 2 170 ? 204.051 234.267 217.972 1.00 77.07  ? 182 ALA A CA    1 
ATOM 1795 C C     . ALA D 2 170 ? 203.153 234.739 219.108 1.00 77.07  ? 182 ALA A C     1 
ATOM 1796 O O     . ALA D 2 170 ? 203.562 235.577 219.920 1.00 77.07  ? 182 ALA A O     1 
ATOM 1797 C CB    . ALA D 2 170 ? 203.809 235.101 216.715 1.00 77.07  ? 182 ALA A CB    1 
ATOM 1798 N N     . VAL D 2 171 ? 201.929 234.217 219.185 1.00 76.04  ? 183 VAL A N     1 
ATOM 1799 C CA    . VAL D 2 171 ? 200.992 234.706 220.191 1.00 76.04  ? 183 VAL A CA    1 
ATOM 1800 C C     . VAL D 2 171 ? 201.285 234.107 221.564 1.00 76.04  ? 183 VAL A C     1 
ATOM 1801 O O     . VAL D 2 171 ? 200.980 234.728 222.589 1.00 76.04  ? 183 VAL A O     1 
ATOM 1802 C CB    . VAL D 2 171 ? 199.543 234.433 219.750 1.00 76.04  ? 183 VAL A CB    1 
ATOM 1803 C CG1   . VAL D 2 171 ? 199.219 232.949 219.832 1.00 76.04  ? 183 VAL A CG1   1 
ATOM 1804 C CG2   . VAL D 2 171 ? 198.567 235.247 220.587 1.00 76.04  ? 183 VAL A CG2   1 
ATOM 1805 N N     . LYS D 2 172 ? 201.879 232.919 221.621 1.00 77.24  ? 184 LYS A N     1 
ATOM 1806 C CA    . LYS D 2 172 ? 202.155 232.299 222.908 1.00 77.24  ? 184 LYS A CA    1 
ATOM 1807 C C     . LYS D 2 172 ? 203.295 233.021 223.617 1.00 77.24  ? 184 LYS A C     1 
ATOM 1808 O O     . LYS D 2 172 ? 204.194 233.585 222.988 1.00 77.24  ? 184 LYS A O     1 
ATOM 1809 C CB    . LYS D 2 172 ? 202.486 230.816 222.735 1.00 77.24  ? 184 LYS A CB    1 
ATOM 1810 C CG    . LYS D 2 172 ? 203.790 230.534 222.017 1.00 77.24  ? 184 LYS A CG    1 
ATOM 1811 C CD    . LYS D 2 172 ? 204.057 229.039 221.908 1.00 77.24  ? 184 LYS A CD    1 
ATOM 1812 C CE    . LYS D 2 172 ? 202.773 228.243 221.750 1.00 77.24  ? 184 LYS A CE    1 
ATOM 1813 N NZ    . LYS D 2 172 ? 203.045 226.809 221.463 1.00 77.24  ? 184 LYS A NZ    1 
ATOM 1814 N N     . GLY D 2 173 ? 203.244 233.003 224.946 1.00 84.49  ? 185 GLY A N     1 
ATOM 1815 C CA    . GLY D 2 173 ? 204.177 233.755 225.753 1.00 84.49  ? 185 GLY A CA    1 
ATOM 1816 C C     . GLY D 2 173 ? 205.524 233.077 225.893 1.00 84.49  ? 185 GLY A C     1 
ATOM 1817 O O     . GLY D 2 173 ? 205.756 231.960 225.430 1.00 84.49  ? 185 GLY A O     1 
ATOM 1818 N N     . VAL D 2 174 ? 206.437 233.793 226.552 1.00 87.83  ? 186 VAL A N     1 
ATOM 1819 C CA    . VAL D 2 174 ? 207.777 233.265 226.792 1.00 87.83  ? 186 VAL A CA    1 
ATOM 1820 C C     . VAL D 2 174 ? 207.711 232.051 227.707 1.00 87.83  ? 186 VAL A C     1 
ATOM 1821 O O     . VAL D 2 174 ? 208.474 231.088 227.548 1.00 87.83  ? 186 VAL A O     1 
ATOM 1822 C CB    . VAL D 2 174 ? 208.682 234.366 227.375 1.00 87.83  ? 186 VAL A CB    1 
ATOM 1823 C CG1   . VAL D 2 174 ? 210.089 233.839 227.609 1.00 87.83  ? 186 VAL A CG1   1 
ATOM 1824 C CG2   . VAL D 2 174 ? 208.699 235.580 226.459 1.00 87.83  ? 186 VAL A CG2   1 
ATOM 1825 N N     . GLY D 2 175 ? 206.795 232.076 228.676 1.00 88.51  ? 187 GLY A N     1 
ATOM 1826 C CA    . GLY D 2 175 ? 206.713 230.989 229.636 1.00 88.51  ? 187 GLY A CA    1 
ATOM 1827 C C     . GLY D 2 175 ? 206.361 229.660 228.999 1.00 88.51  ? 187 GLY A C     1 
ATOM 1828 O O     . GLY D 2 175 ? 206.866 228.617 229.408 1.00 88.51  ? 187 GLY A O     1 
ATOM 1829 N N     . THR D 2 176 ? 205.483 229.677 227.994 1.00 87.84  ? 188 THR A N     1 
ATOM 1830 C CA    . THR D 2 176 ? 205.122 228.435 227.315 1.00 87.84  ? 188 THR A CA    1 
ATOM 1831 C C     . THR D 2 176 ? 206.302 227.860 226.541 1.00 87.84  ? 188 THR A C     1 
ATOM 1832 O O     . THR D 2 176 ? 206.521 226.641 226.542 1.00 87.84  ? 188 THR A O     1 
ATOM 1833 C CB    . THR D 2 176 ? 203.938 228.677 226.384 1.00 87.84  ? 188 THR A CB    1 
ATOM 1834 O OG1   . THR D 2 176 ? 204.417 229.104 225.104 1.00 87.84  ? 188 THR A OG1   1 
ATOM 1835 C CG2   . THR D 2 176 ? 203.044 229.748 226.964 1.00 87.84  ? 188 THR A CG2   1 
ATOM 1836 N N     . MET D 2 177 ? 207.069 228.720 225.869 1.00 94.02  ? 189 MET A N     1 
ATOM 1837 C CA    . MET D 2 177 ? 208.271 228.255 225.185 1.00 94.02  ? 189 MET A CA    1 
ATOM 1838 C C     . MET D 2 177 ? 209.272 227.681 226.174 1.00 94.02  ? 189 MET A C     1 
ATOM 1839 O O     . MET D 2 177 ? 209.889 226.640 225.915 1.00 94.02  ? 189 MET A O     1 
ATOM 1840 C CB    . MET D 2 177 ? 208.899 229.396 224.386 1.00 94.02  ? 189 MET A CB    1 
ATOM 1841 C CG    . MET D 2 177 ? 207.986 229.989 223.331 1.00 94.02  ? 189 MET A CG    1 
ATOM 1842 S SD    . MET D 2 177 ? 207.614 228.844 221.989 1.00 94.02  ? 189 MET A SD    1 
ATOM 1843 C CE    . MET D 2 177 ? 209.151 227.930 221.857 1.00 94.02  ? 189 MET A CE    1 
ATOM 1844 N N     . VAL D 2 178 ? 209.444 228.343 227.318 1.00 96.50  ? 190 VAL A N     1 
ATOM 1845 C CA    . VAL D 2 178 ? 210.340 227.810 228.336 1.00 96.50  ? 190 VAL A CA    1 
ATOM 1846 C C     . VAL D 2 178 ? 209.821 226.475 228.853 1.00 96.50  ? 190 VAL A C     1 
ATOM 1847 O O     . VAL D 2 178 ? 210.599 225.553 229.101 1.00 96.50  ? 190 VAL A O     1 
ATOM 1848 C CB    . VAL D 2 178 ? 210.532 228.831 229.472 1.00 96.50  ? 190 VAL A CB    1 
ATOM 1849 C CG1   . VAL D 2 178 ? 211.392 228.241 230.576 1.00 96.50  ? 190 VAL A CG1   1 
ATOM 1850 C CG2   . VAL D 2 178 ? 211.167 230.100 228.932 1.00 96.50  ? 190 VAL A CG2   1 
ATOM 1851 N N     . MET D 2 179 ? 208.504 226.345 229.011 1.00 98.06  ? 191 MET A N     1 
ATOM 1852 C CA    . MET D 2 179 ? 207.926 225.090 229.484 1.00 98.06  ? 191 MET A CA    1 
ATOM 1853 C C     . MET D 2 179 ? 208.206 223.958 228.504 1.00 98.06  ? 191 MET A C     1 
ATOM 1854 O O     . MET D 2 179 ? 208.568 222.846 228.906 1.00 98.06  ? 191 MET A O     1 
ATOM 1855 C CB    . MET D 2 179 ? 206.423 225.264 229.702 1.00 98.06  ? 191 MET A CB    1 
ATOM 1856 C CG    . MET D 2 179 ? 205.842 224.385 230.795 1.00 98.06  ? 191 MET A CG    1 
ATOM 1857 S SD    . MET D 2 179 ? 205.398 222.744 230.198 1.00 98.06  ? 191 MET A SD    1 
ATOM 1858 C CE    . MET D 2 179 ? 203.791 223.073 229.480 1.00 98.06  ? 191 MET A CE    1 
ATOM 1859 N N     . GLU D 2 180 ? 208.051 224.229 227.207 1.00 105.63 ? 192 GLU A N     1 
ATOM 1860 C CA    . GLU D 2 180 ? 208.387 223.231 226.195 1.00 105.63 ? 192 GLU A CA    1 
ATOM 1861 C C     . GLU D 2 180 ? 209.871 222.883 226.236 1.00 105.63 ? 192 GLU A C     1 
ATOM 1862 O O     . GLU D 2 180 ? 210.250 221.711 226.102 1.00 105.63 ? 192 GLU A O     1 
ATOM 1863 C CB    . GLU D 2 180 ? 207.990 223.740 224.807 1.00 105.63 ? 192 GLU A CB    1 
ATOM 1864 C CG    . GLU D 2 180 ? 206.482 223.906 224.526 1.00 105.63 ? 192 GLU A CG    1 
ATOM 1865 C CD    . GLU D 2 180 ? 206.109 224.484 223.156 1.00 105.63 ? 192 GLU A CD    1 
ATOM 1866 O OE1   . GLU D 2 180 ? 207.040 224.949 222.463 1.00 105.63 ? 192 GLU A OE1   1 
ATOM 1867 O OE2   . GLU D 2 180 ? 204.938 224.427 222.726 1.00 105.63 ? 192 GLU A OE2   1 
ATOM 1868 N N     . LEU D 2 181 ? 210.727 223.891 226.424 1.00 107.04 ? 193 LEU A N     1 
ATOM 1869 C CA    . LEU D 2 181 ? 212.164 223.642 226.503 1.00 107.04 ? 193 LEU A CA    1 
ATOM 1870 C C     . LEU D 2 181 ? 212.513 222.754 227.692 1.00 107.04 ? 193 LEU A C     1 
ATOM 1871 O O     . LEU D 2 181 ? 213.319 221.826 227.568 1.00 107.04 ? 193 LEU A O     1 
ATOM 1872 C CB    . LEU D 2 181 ? 212.915 224.970 226.586 1.00 107.04 ? 193 LEU A CB    1 
ATOM 1873 C CG    . LEU D 2 181 ? 213.141 225.697 225.261 1.00 107.04 ? 193 LEU A CG    1 
ATOM 1874 C CD1   . LEU D 2 181 ? 213.858 227.013 225.488 1.00 107.04 ? 193 LEU A CD1   1 
ATOM 1875 C CD2   . LEU D 2 181 ? 213.940 224.817 224.321 1.00 107.04 ? 193 LEU A CD2   1 
ATOM 1876 N N     . ILE D 2 182 ? 211.915 223.020 228.853 1.00 110.07 ? 194 ILE A N     1 
ATOM 1877 C CA    . ILE D 2 182 ? 212.190 222.204 230.033 1.00 110.07 ? 194 ILE A CA    1 
ATOM 1878 C C     . ILE D 2 182 ? 211.602 220.807 229.888 1.00 110.07 ? 194 ILE A C     1 
ATOM 1879 O O     . ILE D 2 182 ? 212.161 219.839 230.410 1.00 110.07 ? 194 ILE A O     1 
ATOM 1880 C CB    . ILE D 2 182 ? 211.708 222.900 231.320 1.00 110.07 ? 194 ILE A CB    1 
ATOM 1881 C CG1   . ILE D 2 182 ? 212.071 224.384 231.309 1.00 110.07 ? 194 ILE A CG1   1 
ATOM 1882 C CG2   . ILE D 2 182 ? 212.269 222.212 232.539 1.00 110.07 ? 194 ILE A CG2   1 
ATOM 1883 C CD1   . ILE D 2 182 ? 213.545 224.651 231.110 1.00 110.07 ? 194 ILE A CD1   1 
ATOM 1884 N N     . ARG D 2 183 ? 210.467 220.668 229.201 1.00 112.44 ? 195 ARG A N     1 
ATOM 1885 C CA    . ARG D 2 183 ? 209.975 219.323 228.914 1.00 112.44 ? 195 ARG A CA    1 
ATOM 1886 C C     . ARG D 2 183 ? 210.963 218.556 228.042 1.00 112.44 ? 195 ARG A C     1 
ATOM 1887 O O     . ARG D 2 183 ? 211.232 217.372 228.285 1.00 112.44 ? 195 ARG A O     1 
ATOM 1888 C CB    . ARG D 2 183 ? 208.601 219.381 228.250 1.00 112.44 ? 195 ARG A CB    1 
ATOM 1889 C CG    . ARG D 2 183 ? 207.810 218.089 228.404 1.00 112.44 ? 195 ARG A CG    1 
ATOM 1890 C CD    . ARG D 2 183 ? 206.311 218.323 228.470 1.00 112.44 ? 195 ARG A CD    1 
ATOM 1891 N NE    . ARG D 2 183 ? 205.881 218.759 229.793 1.00 112.44 ? 195 ARG A NE    1 
ATOM 1892 C CZ    . ARG D 2 183 ? 204.761 219.426 230.033 1.00 112.44 ? 195 ARG A CZ    1 
ATOM 1893 N NH1   . ARG D 2 183 ? 203.929 219.753 229.058 1.00 112.44 ? 195 ARG A NH1   1 
ATOM 1894 N NH2   . ARG D 2 183 ? 204.466 219.771 231.283 1.00 112.44 ? 195 ARG A NH2   1 
ATOM 1895 N N     . MET D 2 184 ? 211.527 219.224 227.032 1.00 114.78 ? 196 MET A N     1 
ATOM 1896 C CA    . MET D 2 184 ? 212.562 218.594 226.218 1.00 114.78 ? 196 MET A CA    1 
ATOM 1897 C C     . MET D 2 184 ? 213.772 218.209 227.064 1.00 114.78 ? 196 MET A C     1 
ATOM 1898 O O     . MET D 2 184 ? 214.317 217.109 226.920 1.00 114.78 ? 196 MET A O     1 
ATOM 1899 C CB    . MET D 2 184 ? 212.978 219.530 225.084 1.00 114.78 ? 196 MET A CB    1 
ATOM 1900 C CG    . MET D 2 184 ? 211.909 219.740 224.025 1.00 114.78 ? 196 MET A CG    1 
ATOM 1901 S SD    . MET D 2 184 ? 212.089 218.629 222.619 1.00 114.78 ? 196 MET A SD    1 
ATOM 1902 C CE    . MET D 2 184 ? 213.092 219.635 221.529 1.00 114.78 ? 196 MET A CE    1 
ATOM 1903 N N     . ILE D 2 185 ? 214.198 219.101 227.962 1.00 120.74 ? 197 ILE A N     1 
ATOM 1904 C CA    . ILE D 2 185 ? 215.368 218.828 228.796 1.00 120.74 ? 197 ILE A CA    1 
ATOM 1905 C C     . ILE D 2 185 ? 215.097 217.664 229.743 1.00 120.74 ? 197 ILE A C     1 
ATOM 1906 O O     . ILE D 2 185 ? 215.975 216.831 229.992 1.00 120.74 ? 197 ILE A O     1 
ATOM 1907 C CB    . ILE D 2 185 ? 215.789 220.096 229.563 1.00 120.74 ? 197 ILE A CB    1 
ATOM 1908 C CG1   . ILE D 2 185 ? 216.204 221.197 228.588 1.00 120.74 ? 197 ILE A CG1   1 
ATOM 1909 C CG2   . ILE D 2 185 ? 216.926 219.793 230.526 1.00 120.74 ? 197 ILE A CG2   1 
ATOM 1910 C CD1   . ILE D 2 185 ? 217.336 220.801 227.676 1.00 120.74 ? 197 ILE A CD1   1 
ATOM 1911 N N     . LYS D 2 186 ? 213.889 217.599 230.301 1.00 130.75 ? 198 LYS A N     1 
ATOM 1912 C CA    . LYS D 2 186 ? 213.530 216.505 231.198 1.00 130.75 ? 198 LYS A CA    1 
ATOM 1913 C C     . LYS D 2 186 ? 213.526 215.179 230.447 1.00 130.75 ? 198 LYS A C     1 
ATOM 1914 O O     . LYS D 2 186 ? 214.067 214.175 230.930 1.00 130.75 ? 198 LYS A O     1 
ATOM 1915 C CB    . LYS D 2 186 ? 212.167 216.808 231.836 1.00 130.75 ? 198 LYS A CB    1 
ATOM 1916 C CG    . LYS D 2 186 ? 212.022 218.098 232.662 1.00 130.75 ? 198 LYS A CG    1 
ATOM 1917 C CD    . LYS D 2 186 ? 212.967 218.211 233.851 1.00 130.75 ? 198 LYS A CD    1 
ATOM 1918 C CE    . LYS D 2 186 ? 212.589 217.218 234.941 1.00 130.75 ? 198 LYS A CE    1 
ATOM 1919 N NZ    . LYS D 2 186 ? 213.383 217.408 236.187 1.00 130.75 ? 198 LYS A NZ    1 
ATOM 1920 N N     . ARG D 2 187 ? 212.939 215.164 229.246 1.00 134.31 ? 199 ARG A N     1 
ATOM 1921 C CA    . ARG D 2 187 ? 212.978 213.956 228.430 1.00 134.31 ? 199 ARG A CA    1 
ATOM 1922 C C     . ARG D 2 187 ? 214.406 213.587 228.049 1.00 134.31 ? 199 ARG A C     1 
ATOM 1923 O O     . ARG D 2 187 ? 214.712 212.404 227.861 1.00 134.31 ? 199 ARG A O     1 
ATOM 1924 C CB    . ARG D 2 187 ? 212.118 214.143 227.181 1.00 134.31 ? 199 ARG A CB    1 
ATOM 1925 C CG    . ARG D 2 187 ? 210.627 214.190 227.474 1.00 134.31 ? 199 ARG A CG    1 
ATOM 1926 C CD    . ARG D 2 187 ? 209.800 214.235 226.201 1.00 134.31 ? 199 ARG A CD    1 
ATOM 1927 N NE    . ARG D 2 187 ? 208.371 214.255 226.490 1.00 134.31 ? 199 ARG A NE    1 
ATOM 1928 C CZ    . ARG D 2 187 ? 207.420 214.357 225.571 1.00 134.31 ? 199 ARG A CZ    1 
ATOM 1929 N NH1   . ARG D 2 187 ? 207.711 214.454 224.284 1.00 134.31 ? 199 ARG A NH1   1 
ATOM 1930 N NH2   . ARG D 2 187 ? 206.146 214.364 225.953 1.00 134.31 ? 199 ARG A NH2   1 
ATOM 1931 N N     . GLY D 2 188 ? 215.290 214.581 227.931 1.00 137.27 ? 200 GLY A N     1 
ATOM 1932 C CA    . GLY D 2 188 ? 216.683 214.293 227.639 1.00 137.27 ? 200 GLY A CA    1 
ATOM 1933 C C     . GLY D 2 188 ? 217.451 213.737 228.819 1.00 137.27 ? 200 GLY A C     1 
ATOM 1934 O O     . GLY D 2 188 ? 218.339 212.899 228.645 1.00 137.27 ? 200 GLY A O     1 
ATOM 1935 N N     . ILE D 2 189 ? 217.144 214.206 230.025 1.00 136.90 ? 201 ILE A N     1 
ATOM 1936 C CA    . ILE D 2 189 ? 217.776 213.638 231.210 1.00 136.90 ? 201 ILE A CA    1 
ATOM 1937 C C     . ILE D 2 189 ? 217.231 212.241 231.484 1.00 136.90 ? 201 ILE A C     1 
ATOM 1938 O O     . ILE D 2 189 ? 217.918 211.410 232.089 1.00 136.90 ? 201 ILE A O     1 
ATOM 1939 C CB    . ILE D 2 189 ? 217.598 214.570 232.423 1.00 136.90 ? 201 ILE A CB    1 
ATOM 1940 C CG1   . ILE D 2 189 ? 218.071 215.985 232.086 1.00 136.90 ? 201 ILE A CG1   1 
ATOM 1941 C CG2   . ILE D 2 189 ? 218.361 214.044 233.632 1.00 136.90 ? 201 ILE A CG2   1 
ATOM 1942 C CD1   . ILE D 2 189 ? 219.576 216.140 232.056 1.00 136.90 ? 201 ILE A CD1   1 
ATOM 1943 N N     . ASN D 2 190 ? 216.006 211.953 231.033 1.00 144.06 ? 202 ASN A N     1 
ATOM 1944 C CA    . ASN D 2 190 ? 215.423 210.635 231.270 1.00 144.06 ? 202 ASN A CA    1 
ATOM 1945 C C     . ASN D 2 190 ? 216.238 209.527 230.611 1.00 144.06 ? 202 ASN A C     1 
ATOM 1946 O O     . ASN D 2 190 ? 216.481 208.481 231.224 1.00 144.06 ? 202 ASN A O     1 
ATOM 1947 C CB    . ASN D 2 190 ? 213.979 210.603 230.773 1.00 144.06 ? 202 ASN A CB    1 
ATOM 1948 C CG    . ASN D 2 190 ? 213.021 211.280 231.729 1.00 144.06 ? 202 ASN A CG    1 
ATOM 1949 O OD1   . ASN D 2 190 ? 211.920 211.677 231.347 1.00 144.06 ? 202 ASN A OD1   1 
ATOM 1950 N ND2   . ASN D 2 190 ? 213.437 211.417 232.983 1.00 144.06 ? 202 ASN A ND2   1 
ATOM 1951 N N     . ASP D 2 191 ? 216.608 209.746 229.340 1.00 152.00 ? 203 ASP A N     1 
ATOM 1952 C CA    . ASP D 2 191 ? 217.317 208.687 228.566 1.00 152.00 ? 203 ASP A CA    1 
ATOM 1953 C C     . ASP D 2 191 ? 218.522 209.253 227.811 1.00 152.00 ? 203 ASP A C     1 
ATOM 1954 O O     . ASP D 2 191 ? 218.473 210.431 227.416 1.00 152.00 ? 203 ASP A O     1 
ATOM 1955 C CB    . ASP D 2 191 ? 216.374 207.992 227.597 1.00 152.00 ? 203 ASP A CB    1 
ATOM 1956 C CG    . ASP D 2 191 ? 215.337 207.085 228.242 1.00 152.00 ? 203 ASP A CG    1 
ATOM 1957 O OD1   . ASP D 2 191 ? 215.508 206.757 229.435 1.00 152.00 ? 203 ASP A OD1   1 
ATOM 1958 O OD2   . ASP D 2 191 ? 214.366 206.722 227.549 1.00 152.00 ? 203 ASP A OD2   1 
ATOM 1959 N N     . ARG D 2 192 ? 219.533 208.418 227.563 1.00 161.05 ? 204 ARG A N     1 
ATOM 1960 C CA    . ARG D 2 192 ? 220.762 208.832 226.899 1.00 161.05 ? 204 ARG A CA    1 
ATOM 1961 C C     . ARG D 2 192 ? 220.699 208.705 225.382 1.00 161.05 ? 204 ARG A C     1 
ATOM 1962 O O     . ARG D 2 192 ? 221.422 209.426 224.685 1.00 161.05 ? 204 ARG A O     1 
ATOM 1963 C CB    . ARG D 2 192 ? 221.947 208.014 227.432 1.00 161.05 ? 204 ARG A CB    1 
ATOM 1964 C CG    . ARG D 2 192 ? 223.313 208.493 226.959 1.00 161.05 ? 204 ARG A CG    1 
ATOM 1965 C CD    . ARG D 2 192 ? 224.438 207.712 227.621 1.00 161.05 ? 204 ARG A CD    1 
ATOM 1966 N NE    . ARG D 2 192 ? 225.750 208.159 227.167 1.00 161.05 ? 204 ARG A NE    1 
ATOM 1967 C CZ    . ARG D 2 192 ? 226.380 209.229 227.630 1.00 161.05 ? 204 ARG A CZ    1 
ATOM 1968 N NH1   . ARG D 2 192 ? 225.850 209.990 228.573 1.00 161.05 ? 204 ARG A NH1   1 
ATOM 1969 N NH2   . ARG D 2 192 ? 227.572 209.546 227.131 1.00 161.05 ? 204 ARG A NH2   1 
ATOM 1970 N N     . ASN D 2 193 ? 219.846 207.831 224.854 1.00 153.49 ? 205 ASN A N     1 
ATOM 1971 C CA    . ASN D 2 193 ? 219.764 207.578 223.420 1.00 153.49 ? 205 ASN A CA    1 
ATOM 1972 C C     . ASN D 2 193 ? 219.110 208.718 222.646 1.00 153.49 ? 205 ASN A C     1 
ATOM 1973 O O     . ASN D 2 193 ? 218.811 208.550 221.460 1.00 153.49 ? 205 ASN A O     1 
ATOM 1974 C CB    . ASN D 2 193 ? 219.001 206.277 223.161 1.00 153.49 ? 205 ASN A CB    1 
ATOM 1975 C CG    . ASN D 2 193 ? 219.791 205.049 223.565 1.00 153.49 ? 205 ASN A CG    1 
ATOM 1976 O OD1   . ASN D 2 193 ? 221.019 205.084 223.642 1.00 153.49 ? 205 ASN A OD1   1 
ATOM 1977 N ND2   . ASN D 2 193 ? 219.088 203.955 223.833 1.00 153.49 ? 205 ASN A ND2   1 
ATOM 1978 N N     . PHE D 2 194 ? 218.922 209.834 223.355 1.00 146.95 ? 206 PHE A N     1 
ATOM 1979 C CA    . PHE D 2 194 ? 218.315 211.043 222.757 1.00 146.95 ? 206 PHE A CA    1 
ATOM 1980 C C     . PHE D 2 194 ? 219.403 211.814 222.014 1.00 146.95 ? 206 PHE A C     1 
ATOM 1981 O O     . PHE D 2 194 ? 220.566 211.363 222.024 1.00 146.95 ? 206 PHE A O     1 
ATOM 1982 C CB    . PHE D 2 194 ? 217.703 211.869 223.891 1.00 146.95 ? 206 PHE A CB    1 
ATOM 1983 C CG    . PHE D 2 194 ? 216.960 213.119 223.496 1.00 146.95 ? 206 PHE A CG    1 
ATOM 1984 C CD1   . PHE D 2 194 ? 215.775 213.049 222.783 1.00 146.95 ? 206 PHE A CD1   1 
ATOM 1985 C CD2   . PHE D 2 194 ? 217.434 214.367 223.865 1.00 146.95 ? 206 PHE A CD2   1 
ATOM 1986 C CE1   . PHE D 2 194 ? 215.089 214.201 222.436 1.00 146.95 ? 206 PHE A CE1   1 
ATOM 1987 C CE2   . PHE D 2 194 ? 216.749 215.519 223.515 1.00 146.95 ? 206 PHE A CE2   1 
ATOM 1988 C CZ    . PHE D 2 194 ? 215.578 215.434 222.801 1.00 146.95 ? 206 PHE A CZ    1 
ATOM 1989 N N     . TRP D 2 195 ? 219.045 212.952 221.425 1.00 146.39 ? 207 TRP A N     1 
ATOM 1990 C CA    . TRP D 2 195 ? 219.984 213.756 220.636 1.00 146.39 ? 207 TRP A CA    1 
ATOM 1991 C C     . TRP D 2 195 ? 220.686 212.929 219.568 1.00 146.39 ? 207 TRP A C     1 
ATOM 1992 O O     . TRP D 2 195 ? 221.474 213.486 218.794 1.00 146.39 ? 207 TRP A O     1 
ATOM 1993 C CB    . TRP D 2 195 ? 221.078 214.469 221.452 1.00 146.39 ? 207 TRP A CB    1 
ATOM 1994 C CG    . TRP D 2 195 ? 220.633 215.201 222.674 1.00 146.39 ? 207 TRP A CG    1 
ATOM 1995 C CD1   . TRP D 2 195 ? 220.813 214.821 223.971 1.00 146.39 ? 207 TRP A CD1   1 
ATOM 1996 C CD2   . TRP D 2 195 ? 219.926 216.443 222.715 1.00 146.39 ? 207 TRP A CD2   1 
ATOM 1997 N NE1   . TRP D 2 195 ? 220.272 215.754 224.818 1.00 146.39 ? 207 TRP A NE1   1 
ATOM 1998 C CE2   . TRP D 2 195 ? 219.725 216.764 224.071 1.00 146.39 ? 207 TRP A CE2   1 
ATOM 1999 C CE3   . TRP D 2 195 ? 219.450 217.320 221.737 1.00 146.39 ? 207 TRP A CE3   1 
ATOM 2000 C CZ2   . TRP D 2 195 ? 219.048 217.909 224.472 1.00 146.39 ? 207 TRP A CZ2   1 
ATOM 2001 C CZ3   . TRP D 2 195 ? 218.790 218.464 222.138 1.00 146.39 ? 207 TRP A CZ3   1 
ATOM 2002 C CH2   . TRP D 2 195 ? 218.595 218.748 223.494 1.00 146.39 ? 207 TRP A CH2   1 
ATOM 2003 N N     . ARG D 2 196 ? 220.434 211.625 219.498 1.00 146.27 ? 208 ARG A N     1 
ATOM 2004 C CA    . ARG D 2 196 ? 221.114 210.753 218.554 1.00 146.27 ? 208 ARG A CA    1 
ATOM 2005 C C     . ARG D 2 196 ? 220.093 209.838 217.894 1.00 146.27 ? 208 ARG A C     1 
ATOM 2006 O O     . ARG D 2 196 ? 219.014 209.583 218.435 1.00 146.27 ? 208 ARG A O     1 
ATOM 2007 C CB    . ARG D 2 196 ? 222.215 209.936 219.243 1.00 146.27 ? 208 ARG A CB    1 
ATOM 2008 C CG    . ARG D 2 196 ? 221.699 208.879 220.203 1.00 146.27 ? 208 ARG A CG    1 
ATOM 2009 C CD    . ARG D 2 196 ? 222.826 208.261 221.017 1.00 146.27 ? 208 ARG A CD    1 
ATOM 2010 N NE    . ARG D 2 196 ? 223.364 209.194 222.001 1.00 146.27 ? 208 ARG A NE    1 
ATOM 2011 C CZ    . ARG D 2 196 ? 224.477 209.896 221.841 1.00 146.27 ? 208 ARG A CZ    1 
ATOM 2012 N NH1   . ARG D 2 196 ? 225.210 209.791 220.745 1.00 146.27 ? 208 ARG A NH1   1 
ATOM 2013 N NH2   . ARG D 2 196 ? 224.866 210.725 222.806 1.00 146.27 ? 208 ARG A NH2   1 
ATOM 2014 N N     . GLY D 2 197 ? 220.449 209.347 216.711 1.00 139.60 ? 209 GLY A N     1 
ATOM 2015 C CA    . GLY D 2 197 ? 219.550 208.520 215.934 1.00 139.60 ? 209 GLY A CA    1 
ATOM 2016 C C     . GLY D 2 197 ? 218.672 209.332 215.007 1.00 139.60 ? 209 GLY A C     1 
ATOM 2017 O O     . GLY D 2 197 ? 218.798 210.553 214.867 1.00 139.60 ? 209 GLY A O     1 
ATOM 2018 N N     . GLU D 2 198 ? 217.755 208.621 214.345 1.00 142.06 ? 210 GLU A N     1 
ATOM 2019 C CA    . GLU D 2 198 ? 216.843 209.276 213.413 1.00 142.06 ? 210 GLU A CA    1 
ATOM 2020 C C     . GLU D 2 198 ? 215.944 210.275 214.131 1.00 142.06 ? 210 GLU A C     1 
ATOM 2021 O O     . GLU D 2 198 ? 215.717 211.385 213.637 1.00 142.06 ? 210 GLU A O     1 
ATOM 2022 C CB    . GLU D 2 198 ? 216.006 208.230 212.676 1.00 142.06 ? 210 GLU A CB    1 
ATOM 2023 C CG    . GLU D 2 198 ? 216.820 207.300 211.790 1.00 142.06 ? 210 GLU A CG    1 
ATOM 2024 C CD    . GLU D 2 198 ? 217.638 208.045 210.753 1.00 142.06 ? 210 GLU A CD    1 
ATOM 2025 O OE1   . GLU D 2 198 ? 217.117 209.016 210.165 1.00 142.06 ? 210 GLU A OE1   1 
ATOM 2026 O OE2   . GLU D 2 198 ? 218.804 207.659 210.526 1.00 142.06 ? 210 GLU A OE2   1 
ATOM 2027 N N     . ASN D 2 199 ? 215.422 209.896 215.300 1.00 138.32 ? 211 ASN A N     1 
ATOM 2028 C CA    . ASN D 2 199 ? 214.640 210.834 216.096 1.00 138.32 ? 211 ASN A CA    1 
ATOM 2029 C C     . ASN D 2 199 ? 215.505 211.961 216.644 1.00 138.32 ? 211 ASN A C     1 
ATOM 2030 O O     . ASN D 2 199 ? 214.992 213.048 216.941 1.00 138.32 ? 211 ASN A O     1 
ATOM 2031 C CB    . ASN D 2 199 ? 213.937 210.095 217.236 1.00 138.32 ? 211 ASN A CB    1 
ATOM 2032 C CG    . ASN D 2 199 ? 214.900 209.297 218.098 1.00 138.32 ? 211 ASN A CG    1 
ATOM 2033 O OD1   . ASN D 2 199 ? 216.118 209.411 217.965 1.00 138.32 ? 211 ASN A OD1   1 
ATOM 2034 N ND2   . ASN D 2 199 ? 214.352 208.480 218.990 1.00 138.32 ? 211 ASN A ND2   1 
ATOM 2035 N N     . GLY D 2 200 ? 216.809 211.717 216.795 1.00 136.64 ? 212 GLY A N     1 
ATOM 2036 C CA    . GLY D 2 200 ? 217.694 212.748 217.309 1.00 136.64 ? 212 GLY A CA    1 
ATOM 2037 C C     . GLY D 2 200 ? 217.770 213.960 216.402 1.00 136.64 ? 212 GLY A C     1 
ATOM 2038 O O     . GLY D 2 200 ? 217.747 215.100 216.870 1.00 136.64 ? 212 GLY A O     1 
ATOM 2039 N N     . ARG D 2 201 ? 217.855 213.734 215.090 1.00 138.09 ? 213 ARG A N     1 
ATOM 2040 C CA    . ARG D 2 201 ? 217.897 214.851 214.153 1.00 138.09 ? 213 ARG A CA    1 
ATOM 2041 C C     . ARG D 2 201 ? 216.611 215.666 214.214 1.00 138.09 ? 213 ARG A C     1 
ATOM 2042 O O     . ARG D 2 201 ? 216.645 216.903 214.232 1.00 138.09 ? 213 ARG A O     1 
ATOM 2043 C CB    . ARG D 2 201 ? 218.142 214.335 212.735 1.00 138.09 ? 213 ARG A CB    1 
ATOM 2044 C CG    . ARG D 2 201 ? 218.288 215.432 211.695 1.00 138.09 ? 213 ARG A CG    1 
ATOM 2045 C CD    . ARG D 2 201 ? 219.522 216.276 211.962 1.00 138.09 ? 213 ARG A CD    1 
ATOM 2046 N NE    . ARG D 2 201 ? 220.750 215.502 211.827 1.00 138.09 ? 213 ARG A NE    1 
ATOM 2047 C CZ    . ARG D 2 201 ? 221.962 215.969 212.094 1.00 138.09 ? 213 ARG A CZ    1 
ATOM 2048 N NH1   . ARG D 2 201 ? 222.148 217.209 212.515 1.00 138.09 ? 213 ARG A NH1   1 
ATOM 2049 N NH2   . ARG D 2 201 ? 223.014 215.170 211.936 1.00 138.09 ? 213 ARG A NH2   1 
ATOM 2050 N N     . ARG D 2 202 ? 215.462 214.985 214.249 1.00 134.93 ? 214 ARG A N     1 
ATOM 2051 C CA    . ARG D 2 202 ? 214.183 215.687 214.281 1.00 134.93 ? 214 ARG A CA    1 
ATOM 2052 C C     . ARG D 2 202 ? 214.016 216.481 215.570 1.00 134.93 ? 214 ARG A C     1 
ATOM 2053 O O     . ARG D 2 202 ? 213.565 217.633 215.542 1.00 134.93 ? 214 ARG A O     1 
ATOM 2054 C CB    . ARG D 2 202 ? 213.032 214.697 214.107 1.00 134.93 ? 214 ARG A CB    1 
ATOM 2055 C CG    . ARG D 2 202 ? 212.923 214.119 212.707 1.00 134.93 ? 214 ARG A CG    1 
ATOM 2056 C CD    . ARG D 2 202 ? 211.713 213.209 212.579 1.00 134.93 ? 214 ARG A CD    1 
ATOM 2057 N NE    . ARG D 2 202 ? 210.467 213.932 212.806 1.00 134.93 ? 214 ARG A NE    1 
ATOM 2058 C CZ    . ARG D 2 202 ? 209.846 214.661 211.888 1.00 134.93 ? 214 ARG A CZ    1 
ATOM 2059 N NH1   . ARG D 2 202 ? 210.329 214.788 210.663 1.00 134.93 ? 214 ARG A NH1   1 
ATOM 2060 N NH2   . ARG D 2 202 ? 208.713 215.280 212.208 1.00 134.93 ? 214 ARG A NH2   1 
ATOM 2061 N N     . THR D 2 203 ? 214.378 215.893 216.711 1.00 129.31 ? 215 THR A N     1 
ATOM 2062 C CA    . THR D 2 203 ? 214.259 216.629 217.963 1.00 129.31 ? 215 THR A CA    1 
ATOM 2063 C C     . THR D 2 203 ? 215.257 217.780 218.017 1.00 129.31 ? 215 THR A C     1 
ATOM 2064 O O     . THR D 2 203 ? 214.970 218.831 218.602 1.00 129.31 ? 215 THR A O     1 
ATOM 2065 C CB    . THR D 2 203 ? 214.429 215.686 219.156 1.00 129.31 ? 215 THR A CB    1 
ATOM 2066 O OG1   . THR D 2 203 ? 214.095 216.379 220.366 1.00 129.31 ? 215 THR A OG1   1 
ATOM 2067 C CG2   . THR D 2 203 ? 215.846 215.165 219.242 1.00 129.31 ? 215 THR A CG2   1 
ATOM 2068 N N     . ARG D 2 204 ? 216.422 217.621 217.381 1.00 126.13 ? 216 ARG A N     1 
ATOM 2069 C CA    . ARG D 2 204 ? 217.390 218.709 217.349 1.00 126.13 ? 216 ARG A CA    1 
ATOM 2070 C C     . ARG D 2 204 ? 216.880 219.874 216.509 1.00 126.13 ? 216 ARG A C     1 
ATOM 2071 O O     . ARG D 2 204 ? 217.031 221.034 216.902 1.00 126.13 ? 216 ARG A O     1 
ATOM 2072 C CB    . ARG D 2 204 ? 218.734 218.201 216.826 1.00 126.13 ? 216 ARG A CB    1 
ATOM 2073 C CG    . ARG D 2 204 ? 219.697 219.287 216.364 1.00 126.13 ? 216 ARG A CG    1 
ATOM 2074 C CD    . ARG D 2 204 ? 220.058 220.239 217.503 1.00 126.13 ? 216 ARG A CD    1 
ATOM 2075 N NE    . ARG D 2 204 ? 220.545 219.542 218.689 1.00 126.13 ? 216 ARG A NE    1 
ATOM 2076 C CZ    . ARG D 2 204 ? 221.720 218.934 218.779 1.00 126.13 ? 216 ARG A CZ    1 
ATOM 2077 N NH1   . ARG D 2 204 ? 222.576 218.928 217.770 1.00 126.13 ? 216 ARG A NH1   1 
ATOM 2078 N NH2   . ARG D 2 204 ? 222.049 218.324 219.914 1.00 126.13 ? 216 ARG A NH2   1 
ATOM 2079 N N     . ILE D 2 205 ? 216.268 219.595 215.354 1.00 123.15 ? 217 ILE A N     1 
ATOM 2080 C CA    . ILE D 2 205 ? 215.760 220.706 214.549 1.00 123.15 ? 217 ILE A CA    1 
ATOM 2081 C C     . ILE D 2 205 ? 214.538 221.327 215.227 1.00 123.15 ? 217 ILE A C     1 
ATOM 2082 O O     . ILE D 2 205 ? 214.309 222.538 215.120 1.00 123.15 ? 217 ILE A O     1 
ATOM 2083 C CB    . ILE D 2 205 ? 215.459 220.266 213.097 1.00 123.15 ? 217 ILE A CB    1 
ATOM 2084 C CG1   . ILE D 2 205 ? 216.733 219.872 212.343 1.00 123.15 ? 217 ILE A CG1   1 
ATOM 2085 C CG2   . ILE D 2 205 ? 214.799 221.364 212.318 1.00 123.15 ? 217 ILE A CG2   1 
ATOM 2086 C CD1   . ILE D 2 205 ? 216.484 219.185 211.010 1.00 123.15 ? 217 ILE A CD1   1 
ATOM 2087 N N     . ALA D 2 206 ? 213.746 220.529 215.949 1.00 119.49 ? 218 ALA A N     1 
ATOM 2088 C CA    . ALA D 2 206 ? 212.640 221.095 216.718 1.00 119.49 ? 218 ALA A CA    1 
ATOM 2089 C C     . ALA D 2 206 ? 213.151 222.041 217.800 1.00 119.49 ? 218 ALA A C     1 
ATOM 2090 O O     . ALA D 2 206 ? 212.611 223.139 217.993 1.00 119.49 ? 218 ALA A O     1 
ATOM 2091 C CB    . ALA D 2 206 ? 211.801 219.975 217.331 1.00 119.49 ? 218 ALA A CB    1 
ATOM 2092 N N     . TYR D 2 207 ? 214.199 221.625 218.518 1.00 117.09 ? 219 TYR A N     1 
ATOM 2093 C CA    . TYR D 2 207 ? 214.835 222.500 219.496 1.00 117.09 ? 219 TYR A CA    1 
ATOM 2094 C C     . TYR D 2 207 ? 215.370 223.753 218.814 1.00 117.09 ? 219 TYR A C     1 
ATOM 2095 O O     . TYR D 2 207 ? 215.204 224.865 219.324 1.00 117.09 ? 219 TYR A O     1 
ATOM 2096 C CB    . TYR D 2 207 ? 215.955 221.730 220.209 1.00 117.09 ? 219 TYR A CB    1 
ATOM 2097 C CG    . TYR D 2 207 ? 216.817 222.489 221.213 1.00 117.09 ? 219 TYR A CG    1 
ATOM 2098 C CD1   . TYR D 2 207 ? 216.326 222.773 222.479 1.00 117.09 ? 219 TYR A CD1   1 
ATOM 2099 C CD2   . TYR D 2 207 ? 218.097 222.930 220.905 1.00 117.09 ? 219 TYR A CD2   1 
ATOM 2100 C CE1   . TYR D 2 207 ? 217.083 223.457 223.408 1.00 117.09 ? 219 TYR A CE1   1 
ATOM 2101 C CE2   . TYR D 2 207 ? 218.864 223.614 221.828 1.00 117.09 ? 219 TYR A CE2   1 
ATOM 2102 C CZ    . TYR D 2 207 ? 218.352 223.878 223.077 1.00 117.09 ? 219 TYR A CZ    1 
ATOM 2103 O OH    . TYR D 2 207 ? 219.109 224.562 223.999 1.00 117.09 ? 219 TYR A OH    1 
ATOM 2104 N N     . GLU D 2 208 ? 215.996 223.588 217.648 1.00 117.00 ? 220 GLU A N     1 
ATOM 2105 C CA    . GLU D 2 208 ? 216.483 224.728 216.879 1.00 117.00 ? 220 GLU A CA    1 
ATOM 2106 C C     . GLU D 2 208 ? 215.369 225.730 216.611 1.00 117.00 ? 220 GLU A C     1 
ATOM 2107 O O     . GLU D 2 208 ? 215.506 226.921 216.908 1.00 117.00 ? 220 GLU A O     1 
ATOM 2108 C CB    . GLU D 2 208 ? 217.086 224.235 215.562 1.00 117.00 ? 220 GLU A CB    1 
ATOM 2109 C CG    . GLU D 2 208 ? 218.352 223.416 215.702 1.00 117.00 ? 220 GLU A CG    1 
ATOM 2110 C CD    . GLU D 2 208 ? 218.863 222.896 214.381 1.00 117.00 ? 220 GLU A CD    1 
ATOM 2111 O OE1   . GLU D 2 208 ? 218.139 223.007 213.369 1.00 117.00 ? 220 GLU A OE1   1 
ATOM 2112 O OE2   . GLU D 2 208 ? 219.998 222.381 214.359 1.00 117.00 ? 220 GLU A OE2   1 
ATOM 2113 N N     . ARG D 2 209 ? 214.250 225.259 216.062 1.00 112.78 ? 221 ARG A N     1 
ATOM 2114 C CA    . ARG D 2 209 ? 213.183 226.170 215.658 1.00 112.78 ? 221 ARG A CA    1 
ATOM 2115 C C     . ARG D 2 209 ? 212.529 226.837 216.862 1.00 112.78 ? 221 ARG A C     1 
ATOM 2116 O O     . ARG D 2 209 ? 212.257 228.045 216.837 1.00 112.78 ? 221 ARG A O     1 
ATOM 2117 C CB    . ARG D 2 209 ? 212.145 225.423 214.822 1.00 112.78 ? 221 ARG A CB    1 
ATOM 2118 C CG    . ARG D 2 209 ? 211.641 226.216 213.625 1.00 112.78 ? 221 ARG A CG    1 
ATOM 2119 C CD    . ARG D 2 209 ? 210.568 225.512 212.773 1.00 112.78 ? 221 ARG A CD    1 
ATOM 2120 N NE    . ARG D 2 209 ? 209.423 224.987 213.513 1.00 112.78 ? 221 ARG A NE    1 
ATOM 2121 C CZ    . ARG D 2 209 ? 209.388 223.824 214.152 1.00 112.78 ? 221 ARG A CZ    1 
ATOM 2122 N NH1   . ARG D 2 209 ? 210.398 222.970 214.095 1.00 112.78 ? 221 ARG A NH1   1 
ATOM 2123 N NH2   . ARG D 2 209 ? 208.300 223.496 214.842 1.00 112.78 ? 221 ARG A NH2   1 
ATOM 2124 N N     . MET D 2 210 ? 212.269 226.075 217.928 1.00 107.42 ? 222 MET A N     1 
ATOM 2125 C CA    . MET D 2 210 ? 211.637 226.676 219.098 1.00 107.42 ? 222 MET A CA    1 
ATOM 2126 C C     . MET D 2 210 ? 212.579 227.644 219.809 1.00 107.42 ? 222 MET A C     1 
ATOM 2127 O O     . MET D 2 210 ? 212.141 228.700 220.289 1.00 107.42 ? 222 MET A O     1 
ATOM 2128 C CB    . MET D 2 210 ? 211.127 225.575 220.033 1.00 107.42 ? 222 MET A CB    1 
ATOM 2129 C CG    . MET D 2 210 ? 212.125 225.025 221.030 1.00 107.42 ? 222 MET A CG    1 
ATOM 2130 S SD    . MET D 2 210 ? 211.353 223.832 222.141 1.00 107.42 ? 222 MET A SD    1 
ATOM 2131 C CE    . MET D 2 210 ? 210.100 223.127 221.073 1.00 107.42 ? 222 MET A CE    1 
ATOM 2132 N N     . CYS D 2 211 ? 213.877 227.340 219.842 1.00 107.29 ? 223 CYS A N     1 
ATOM 2133 C CA    . CYS D 2 211 ? 214.824 228.270 220.435 1.00 107.29 ? 223 CYS A CA    1 
ATOM 2134 C C     . CYS D 2 211 ? 214.990 229.509 219.568 1.00 107.29 ? 223 CYS A C     1 
ATOM 2135 O O     . CYS D 2 211 ? 215.251 230.593 220.085 1.00 107.29 ? 223 CYS A O     1 
ATOM 2136 C CB    . CYS D 2 211 ? 216.168 227.584 220.665 1.00 107.29 ? 223 CYS A CB    1 
ATOM 2137 S SG    . CYS D 2 211 ? 217.205 228.437 221.870 1.00 107.29 ? 223 CYS A SG    1 
ATOM 2138 N N     . ASN D 2 212 ? 214.822 229.378 218.248 1.00 108.44 ? 224 ASN A N     1 
ATOM 2139 C CA    . ASN D 2 212 ? 214.889 230.556 217.386 1.00 108.44 ? 224 ASN A CA    1 
ATOM 2140 C C     . ASN D 2 212 ? 213.648 231.432 217.529 1.00 108.44 ? 224 ASN A C     1 
ATOM 2141 O O     . ASN D 2 212 ? 213.735 232.663 217.434 1.00 108.44 ? 224 ASN A O     1 
ATOM 2142 C CB    . ASN D 2 212 ? 215.088 230.144 215.927 1.00 108.44 ? 224 ASN A CB    1 
ATOM 2143 C CG    . ASN D 2 212 ? 216.474 229.596 215.660 1.00 108.44 ? 224 ASN A CG    1 
ATOM 2144 O OD1   . ASN D 2 212 ? 217.419 229.884 216.392 1.00 108.44 ? 224 ASN A OD1   1 
ATOM 2145 N ND2   . ASN D 2 212 ? 216.603 228.807 214.599 1.00 108.44 ? 224 ASN A ND2   1 
ATOM 2146 N N     . ILE D 2 213 ? 212.478 230.830 217.741 1.00 99.79  ? 225 ILE A N     1 
ATOM 2147 C CA    . ILE D 2 213 ? 211.310 231.681 217.951 1.00 99.79  ? 225 ILE A CA    1 
ATOM 2148 C C     . ILE D 2 213 ? 211.374 232.351 219.324 1.00 99.79  ? 225 ILE A C     1 
ATOM 2149 O O     . ILE D 2 213 ? 210.942 233.501 219.478 1.00 99.79  ? 225 ILE A O     1 
ATOM 2150 C CB    . ILE D 2 213 ? 209.997 230.907 217.721 1.00 99.79  ? 225 ILE A CB    1 
ATOM 2151 C CG1   . ILE D 2 213 ? 209.783 229.815 218.762 1.00 99.79  ? 225 ILE A CG1   1 
ATOM 2152 C CG2   . ILE D 2 213 ? 209.969 230.316 216.318 1.00 99.79  ? 225 ILE A CG2   1 
ATOM 2153 C CD1   . ILE D 2 213 ? 208.503 229.042 218.545 1.00 99.79  ? 225 ILE A CD1   1 
ATOM 2154 N N     . LEU D 2 214 ? 211.940 231.676 220.332 1.00 96.31  ? 226 LEU A N     1 
ATOM 2155 C CA    . LEU D 2 214 ? 212.222 232.365 221.591 1.00 96.31  ? 226 LEU A CA    1 
ATOM 2156 C C     . LEU D 2 214 ? 213.302 233.432 221.405 1.00 96.31  ? 226 LEU A C     1 
ATOM 2157 O O     . LEU D 2 214 ? 213.267 234.487 222.050 1.00 96.31  ? 226 LEU A O     1 
ATOM 2158 C CB    . LEU D 2 214 ? 212.635 231.357 222.663 1.00 96.31  ? 226 LEU A CB    1 
ATOM 2159 C CG    . LEU D 2 214 ? 213.101 231.933 224.003 1.00 96.31  ? 226 LEU A CG    1 
ATOM 2160 C CD1   . LEU D 2 214 ? 212.019 232.802 224.621 1.00 96.31  ? 226 LEU A CD1   1 
ATOM 2161 C CD2   . LEU D 2 214 ? 213.505 230.820 224.956 1.00 96.31  ? 226 LEU A CD2   1 
ATOM 2162 N N     . LYS D 2 215 ? 214.274 233.157 220.531 1.00 102.56 ? 227 LYS A N     1 
ATOM 2163 C CA    . LYS D 2 215 ? 215.288 234.127 220.134 1.00 102.56 ? 227 LYS A CA    1 
ATOM 2164 C C     . LYS D 2 215 ? 214.638 235.413 219.647 1.00 102.56 ? 227 LYS A C     1 
ATOM 2165 O O     . LYS D 2 215 ? 214.970 236.509 220.114 1.00 102.56 ? 227 LYS A O     1 
ATOM 2166 C CB    . LYS D 2 215 ? 216.133 233.493 219.021 1.00 102.56 ? 227 LYS A CB    1 
ATOM 2167 C CG    . LYS D 2 215 ? 217.343 234.225 218.417 1.00 102.56 ? 227 LYS A CG    1 
ATOM 2168 C CD    . LYS D 2 215 ? 218.549 234.431 219.302 1.00 102.56 ? 227 LYS A CD    1 
ATOM 2169 C CE    . LYS D 2 215 ? 219.622 235.166 218.524 1.00 102.56 ? 227 LYS A CE    1 
ATOM 2170 N NZ    . LYS D 2 215 ? 220.118 234.355 217.406 1.00 102.56 ? 227 LYS A NZ    1 
ATOM 2171 N N     . GLY D 2 216 ? 213.702 235.291 218.706 1.00 95.95  ? 228 GLY A N     1 
ATOM 2172 C CA    . GLY D 2 216 ? 213.010 236.448 218.169 1.00 95.95  ? 228 GLY A CA    1 
ATOM 2173 C C     . GLY D 2 216 ? 211.998 237.060 219.115 1.00 95.95  ? 228 GLY A C     1 
ATOM 2174 O O     . GLY D 2 216 ? 211.639 238.230 218.948 1.00 95.95  ? 228 GLY A O     1 
ATOM 2175 N N     . LYS D 2 217 ? 211.530 236.298 220.107 1.00 88.37  ? 229 LYS A N     1 
ATOM 2176 C CA    . LYS D 2 217 ? 210.542 236.833 221.038 1.00 88.37  ? 229 LYS A CA    1 
ATOM 2177 C C     . LYS D 2 217 ? 211.136 237.887 221.965 1.00 88.37  ? 229 LYS A C     1 
ATOM 2178 O O     . LYS D 2 217 ? 210.432 238.823 222.361 1.00 88.37  ? 229 LYS A O     1 
ATOM 2179 C CB    . LYS D 2 217 ? 209.930 235.701 221.864 1.00 88.37  ? 229 LYS A CB    1 
ATOM 2180 C CG    . LYS D 2 217 ? 208.553 236.016 222.427 1.00 88.37  ? 229 LYS A CG    1 
ATOM 2181 C CD    . LYS D 2 217 ? 207.827 234.755 222.866 1.00 88.37  ? 229 LYS A CD    1 
ATOM 2182 C CE    . LYS D 2 217 ? 207.859 233.688 221.787 1.00 88.37  ? 229 LYS A CE    1 
ATOM 2183 N NZ    . LYS D 2 217 ? 206.895 233.980 220.694 1.00 88.37  ? 229 LYS A NZ    1 
ATOM 2184 N N     . PHE D 2 218 ? 212.413 237.764 222.313 1.00 97.59  ? 230 PHE A N     1 
ATOM 2185 C CA    . PHE D 2 218 ? 212.976 238.572 223.383 1.00 97.59  ? 230 PHE A CA    1 
ATOM 2186 C C     . PHE D 2 218 ? 213.300 239.979 222.874 1.00 97.59  ? 230 PHE A C     1 
ATOM 2187 O O     . PHE D 2 218 ? 213.238 240.265 221.676 1.00 97.59  ? 230 PHE A O     1 
ATOM 2188 C CB    . PHE D 2 218 ? 214.219 237.894 223.953 1.00 97.59  ? 230 PHE A CB    1 
ATOM 2189 C CG    . PHE D 2 218 ? 214.004 237.291 225.312 1.00 97.59  ? 230 PHE A CG    1 
ATOM 2190 C CD1   . PHE D 2 218 ? 213.787 238.088 226.415 1.00 97.59  ? 230 PHE A CD1   1 
ATOM 2191 C CD2   . PHE D 2 218 ? 213.966 235.916 225.471 1.00 97.59  ? 230 PHE A CD2   1 
ATOM 2192 C CE1   . PHE D 2 218 ? 213.576 237.534 227.662 1.00 97.59  ? 230 PHE A CE1   1 
ATOM 2193 C CE2   . PHE D 2 218 ? 213.757 235.352 226.714 1.00 97.59  ? 230 PHE A CE2   1 
ATOM 2194 C CZ    . PHE D 2 218 ? 213.559 236.163 227.811 1.00 97.59  ? 230 PHE A CZ    1 
ATOM 2195 N N     . GLN D 2 219 ? 213.648 240.872 223.804 1.00 99.03  ? 231 GLN A N     1 
ATOM 2196 C CA    . GLN D 2 219 ? 213.782 242.292 223.494 1.00 99.03  ? 231 GLN A CA    1 
ATOM 2197 C C     . GLN D 2 219 ? 215.209 242.813 223.620 1.00 99.03  ? 231 GLN A C     1 
ATOM 2198 O O     . GLN D 2 219 ? 215.745 243.364 222.654 1.00 99.03  ? 231 GLN A O     1 
ATOM 2199 C CB    . GLN D 2 219 ? 212.843 243.111 224.392 1.00 99.03  ? 231 GLN A CB    1 
ATOM 2200 C CG    . GLN D 2 219 ? 211.397 243.131 223.925 1.00 99.03  ? 231 GLN A CG    1 
ATOM 2201 C CD    . GLN D 2 219 ? 211.105 244.288 222.991 1.00 99.03  ? 231 GLN A CD    1 
ATOM 2202 O OE1   . GLN D 2 219 ? 211.906 244.611 222.114 1.00 99.03  ? 231 GLN A OE1   1 
ATOM 2203 N NE2   . GLN D 2 219 ? 209.954 244.923 223.178 1.00 99.03  ? 231 GLN A NE2   1 
ATOM 2204 N N     . THR D 2 220 ? 215.846 242.666 224.780 1.00 104.82 ? 232 THR A N     1 
ATOM 2205 C CA    . THR D 2 220 ? 217.141 243.300 224.979 1.00 104.82 ? 232 THR A CA    1 
ATOM 2206 C C     . THR D 2 220 ? 218.283 242.337 224.656 1.00 104.82 ? 232 THR A C     1 
ATOM 2207 O O     . THR D 2 220 ? 218.124 241.115 224.641 1.00 104.82 ? 232 THR A O     1 
ATOM 2208 C CB    . THR D 2 220 ? 217.277 243.830 226.405 1.00 104.82 ? 232 THR A CB    1 
ATOM 2209 O OG1   . THR D 2 220 ? 217.024 242.777 227.340 1.00 104.82 ? 232 THR A OG1   1 
ATOM 2210 C CG2   . THR D 2 220 ? 216.289 244.953 226.642 1.00 104.82 ? 232 THR A CG2   1 
ATOM 2211 N N     . ALA D 2 221 ? 219.461 242.917 224.416 1.00 105.59 ? 233 ALA A N     1 
ATOM 2212 C CA    . ALA D 2 221 ? 220.569 242.180 223.817 1.00 105.59 ? 233 ALA A CA    1 
ATOM 2213 C C     . ALA D 2 221 ? 221.173 241.135 224.748 1.00 105.59 ? 233 ALA A C     1 
ATOM 2214 O O     . ALA D 2 221 ? 221.596 240.075 224.275 1.00 105.59 ? 233 ALA A O     1 
ATOM 2215 C CB    . ALA D 2 221 ? 221.656 243.155 223.364 1.00 105.59 ? 233 ALA A CB    1 
ATOM 2216 N N     . ALA D 2 222 ? 221.244 241.406 226.053 1.00 111.29 ? 234 ALA A N     1 
ATOM 2217 C CA    . ALA D 2 222 ? 221.920 240.483 226.962 1.00 111.29 ? 234 ALA A CA    1 
ATOM 2218 C C     . ALA D 2 222 ? 221.162 239.164 227.083 1.00 111.29 ? 234 ALA A C     1 
ATOM 2219 O O     . ALA D 2 222 ? 221.750 238.081 226.983 1.00 111.29 ? 234 ALA A O     1 
ATOM 2220 C CB    . ALA D 2 222 ? 222.094 241.135 228.333 1.00 111.29 ? 234 ALA A CB    1 
ATOM 2221 N N     . GLN D 2 223 ? 219.849 239.238 227.301 1.00 108.38 ? 235 GLN A N     1 
ATOM 2222 C CA    . GLN D 2 223 ? 219.037 238.027 227.374 1.00 108.38 ? 235 GLN A CA    1 
ATOM 2223 C C     . GLN D 2 223 ? 218.966 237.311 226.030 1.00 108.38 ? 235 GLN A C     1 
ATOM 2224 O O     . GLN D 2 223 ? 218.891 236.075 225.990 1.00 108.38 ? 235 GLN A O     1 
ATOM 2225 C CB    . GLN D 2 223 ? 217.653 238.389 227.911 1.00 108.38 ? 235 GLN A CB    1 
ATOM 2226 C CG    . GLN D 2 223 ? 217.086 239.654 227.295 1.00 108.38 ? 235 GLN A CG    1 
ATOM 2227 C CD    . GLN D 2 223 ? 215.821 240.133 227.982 1.00 108.38 ? 235 GLN A CD    1 
ATOM 2228 O OE1   . GLN D 2 223 ? 215.683 240.022 229.200 1.00 108.38 ? 235 GLN A OE1   1 
ATOM 2229 N NE2   . GLN D 2 223 ? 214.922 240.737 227.213 1.00 108.38 ? 235 GLN A NE2   1 
ATOM 2230 N N     . ARG D 2 224 ? 219.015 238.058 224.926 1.00 106.88 ? 236 ARG A N     1 
ATOM 2231 C CA    . ARG D 2 224 ? 219.122 237.431 223.612 1.00 106.88 ? 236 ARG A CA    1 
ATOM 2232 C C     . ARG D 2 224 ? 220.423 236.643 223.485 1.00 106.88 ? 236 ARG A C     1 
ATOM 2233 O O     . ARG D 2 224 ? 220.441 235.517 222.970 1.00 106.88 ? 236 ARG A O     1 
ATOM 2234 C CB    . ARG D 2 224 ? 219.021 238.493 222.516 1.00 106.88 ? 236 ARG A CB    1 
ATOM 2235 C CG    . ARG D 2 224 ? 217.641 239.100 222.354 1.00 106.88 ? 236 ARG A CG    1 
ATOM 2236 C CD    . ARG D 2 224 ? 217.244 239.153 220.888 1.00 106.88 ? 236 ARG A CD    1 
ATOM 2237 N NE    . ARG D 2 224 ? 217.985 240.170 220.151 1.00 106.88 ? 236 ARG A NE    1 
ATOM 2238 C CZ    . ARG D 2 224 ? 217.782 241.476 220.258 1.00 106.88 ? 236 ARG A CZ    1 
ATOM 2239 N NH1   . ARG D 2 224 ? 216.850 241.969 221.056 1.00 106.88 ? 236 ARG A NH1   1 
ATOM 2240 N NH2   . ARG D 2 224 ? 218.531 242.309 219.542 1.00 106.88 ? 236 ARG A NH2   1 
ATOM 2241 N N     . THR D 2 225 ? 221.527 237.219 223.958 1.00 112.46 ? 237 THR A N     1 
ATOM 2242 C CA    . THR D 2 225 ? 222.792 236.498 223.936 1.00 112.46 ? 237 THR A CA    1 
ATOM 2243 C C     . THR D 2 225 ? 222.723 235.262 224.821 1.00 112.46 ? 237 THR A C     1 
ATOM 2244 O O     . THR D 2 225 ? 223.272 234.210 224.477 1.00 112.46 ? 237 THR A O     1 
ATOM 2245 C CB    . THR D 2 225 ? 223.929 237.421 224.377 1.00 112.46 ? 237 THR A CB    1 
ATOM 2246 O OG1   . THR D 2 225 ? 223.911 238.613 223.582 1.00 112.46 ? 237 THR A OG1   1 
ATOM 2247 C CG2   . THR D 2 225 ? 225.272 236.734 224.196 1.00 112.46 ? 237 THR A CG2   1 
ATOM 2248 N N     . MET D 2 226 ? 222.043 235.369 225.965 1.00 117.12 ? 238 MET A N     1 
ATOM 2249 C CA    . MET D 2 226 ? 221.916 234.224 226.864 1.00 117.12 ? 238 MET A CA    1 
ATOM 2250 C C     . MET D 2 226 ? 221.145 233.082 226.208 1.00 117.12 ? 238 MET A C     1 
ATOM 2251 O O     . MET D 2 226 ? 221.543 231.912 226.308 1.00 117.12 ? 238 MET A O     1 
ATOM 2252 C CB    . MET D 2 226 ? 221.239 234.647 228.168 1.00 117.12 ? 238 MET A CB    1 
ATOM 2253 C CG    . MET D 2 226 ? 221.812 233.961 229.398 1.00 117.12 ? 238 MET A CG    1 
ATOM 2254 S SD    . MET D 2 226 ? 220.971 234.408 230.928 1.00 117.12 ? 238 MET A SD    1 
ATOM 2255 C CE    . MET D 2 226 ? 220.943 232.826 231.768 1.00 117.12 ? 238 MET A CE    1 
ATOM 2256 N N     . VAL D 2 227 ? 220.027 233.398 225.544 1.00 113.65 ? 239 VAL A N     1 
ATOM 2257 C CA    . VAL D 2 227 ? 219.275 232.328 224.891 1.00 113.65 ? 239 VAL A CA    1 
ATOM 2258 C C     . VAL D 2 227 ? 220.090 231.743 223.744 1.00 113.65 ? 239 VAL A C     1 
ATOM 2259 O O     . VAL D 2 227 ? 220.067 230.525 223.515 1.00 113.65 ? 239 VAL A O     1 
ATOM 2260 C CB    . VAL D 2 227 ? 217.877 232.793 224.426 1.00 113.65 ? 239 VAL A CB    1 
ATOM 2261 C CG1   . VAL D 2 227 ? 217.932 234.106 223.699 1.00 113.65 ? 239 VAL A CG1   1 
ATOM 2262 C CG2   . VAL D 2 227 ? 217.208 231.728 223.564 1.00 113.65 ? 239 VAL A CG2   1 
ATOM 2263 N N     . ASP D 2 228 ? 220.860 232.575 223.038 1.00 114.94 ? 240 ASP A N     1 
ATOM 2264 C CA    . ASP D 2 228 ? 221.742 232.044 222.004 1.00 114.94 ? 240 ASP A CA    1 
ATOM 2265 C C     . ASP D 2 228 ? 222.748 231.056 222.590 1.00 114.94 ? 240 ASP A C     1 
ATOM 2266 O O     . ASP D 2 228 ? 222.953 229.964 222.046 1.00 114.94 ? 240 ASP A O     1 
ATOM 2267 C CB    . ASP D 2 228 ? 222.460 233.189 221.291 1.00 114.94 ? 240 ASP A CB    1 
ATOM 2268 C CG    . ASP D 2 228 ? 222.575 232.962 219.798 1.00 114.94 ? 240 ASP A CG    1 
ATOM 2269 O OD1   . ASP D 2 228 ? 222.601 231.787 219.375 1.00 114.94 ? 240 ASP A OD1   1 
ATOM 2270 O OD2   . ASP D 2 228 ? 222.639 233.958 219.048 1.00 114.94 ? 240 ASP A OD2   1 
ATOM 2271 N N     . GLN D 2 229 ? 223.374 231.415 223.717 1.00 119.82 ? 241 GLN A N     1 
ATOM 2272 C CA    . GLN D 2 229 ? 224.364 230.519 224.310 1.00 119.82 ? 241 GLN A CA    1 
ATOM 2273 C C     . GLN D 2 229 ? 223.746 229.213 224.789 1.00 119.82 ? 241 GLN A C     1 
ATOM 2274 O O     . GLN D 2 229 ? 224.332 228.146 224.573 1.00 119.82 ? 241 GLN A O     1 
ATOM 2275 C CB    . GLN D 2 229 ? 225.108 231.185 225.469 1.00 119.82 ? 241 GLN A CB    1 
ATOM 2276 C CG    . GLN D 2 229 ? 225.706 232.541 225.171 1.00 119.82 ? 241 GLN A CG    1 
ATOM 2277 C CD    . GLN D 2 229 ? 225.928 233.350 226.430 1.00 119.82 ? 241 GLN A CD    1 
ATOM 2278 O OE1   . GLN D 2 229 ? 226.711 232.961 227.295 1.00 119.82 ? 241 GLN A OE1   1 
ATOM 2279 N NE2   . GLN D 2 229 ? 225.236 234.476 226.545 1.00 119.82 ? 241 GLN A NE2   1 
ATOM 2280 N N     . VAL D 2 230 ? 222.581 229.261 225.446 1.00 117.76 ? 242 VAL A N     1 
ATOM 2281 C CA    . VAL D 2 230 ? 221.986 227.998 225.884 1.00 117.76 ? 242 VAL A CA    1 
ATOM 2282 C C     . VAL D 2 230 ? 221.569 227.177 224.669 1.00 117.76 ? 242 VAL A C     1 
ATOM 2283 O O     . VAL D 2 230 ? 221.551 225.940 224.718 1.00 117.76 ? 242 VAL A O     1 
ATOM 2284 C CB    . VAL D 2 230 ? 220.812 228.226 226.864 1.00 117.76 ? 242 VAL A CB    1 
ATOM 2285 C CG1   . VAL D 2 230 ? 219.870 229.279 226.360 1.00 117.76 ? 242 VAL A CG1   1 
ATOM 2286 C CG2   . VAL D 2 230 ? 220.069 226.925 227.161 1.00 117.76 ? 242 VAL A CG2   1 
ATOM 2287 N N     . ARG D 2 231 ? 221.264 227.842 223.551 1.00 117.33 ? 243 ARG A N     1 
ATOM 2288 C CA    . ARG D 2 231 ? 221.073 227.122 222.296 1.00 117.33 ? 243 ARG A CA    1 
ATOM 2289 C C     . ARG D 2 231 ? 222.351 226.414 221.858 1.00 117.33 ? 243 ARG A C     1 
ATOM 2290 O O     . ARG D 2 231 ? 222.295 225.284 221.358 1.00 117.33 ? 243 ARG A O     1 
ATOM 2291 C CB    . ARG D 2 231 ? 220.596 228.084 221.209 1.00 117.33 ? 243 ARG A CB    1 
ATOM 2292 C CG    . ARG D 2 231 ? 220.104 227.411 219.937 1.00 117.33 ? 243 ARG A CG    1 
ATOM 2293 C CD    . ARG D 2 231 ? 221.235 227.244 218.926 1.00 117.33 ? 243 ARG A CD    1 
ATOM 2294 N NE    . ARG D 2 231 ? 221.688 228.511 218.361 1.00 117.33 ? 243 ARG A NE    1 
ATOM 2295 C CZ    . ARG D 2 231 ? 220.941 229.331 217.634 1.00 117.33 ? 243 ARG A CZ    1 
ATOM 2296 N NH1   . ARG D 2 231 ? 219.692 229.033 217.313 1.00 117.33 ? 243 ARG A NH1   1 
ATOM 2297 N NH2   . ARG D 2 231 ? 221.466 230.475 217.204 1.00 117.33 ? 243 ARG A NH2   1 
ATOM 2298 N N     . GLU D 2 232 ? 223.508 227.066 222.020 1.00 126.27 ? 244 GLU A N     1 
ATOM 2299 C CA    . GLU D 2 232 ? 224.754 226.497 221.504 1.00 126.27 ? 244 GLU A CA    1 
ATOM 2300 C C     . GLU D 2 232 ? 225.062 225.126 222.095 1.00 126.27 ? 244 GLU A C     1 
ATOM 2301 O O     . GLU D 2 232 ? 225.777 224.334 221.470 1.00 126.27 ? 244 GLU A O     1 
ATOM 2302 C CB    . GLU D 2 232 ? 225.931 227.441 221.764 1.00 126.27 ? 244 GLU A CB    1 
ATOM 2303 C CG    . GLU D 2 232 ? 225.703 228.881 221.354 1.00 126.27 ? 244 GLU A CG    1 
ATOM 2304 C CD    . GLU D 2 232 ? 225.555 229.050 219.854 1.00 126.27 ? 244 GLU A CD    1 
ATOM 2305 O OE1   . GLU D 2 232 ? 226.028 228.171 219.103 1.00 126.27 ? 244 GLU A OE1   1 
ATOM 2306 O OE2   . GLU D 2 232 ? 224.963 230.062 219.426 1.00 126.27 ? 244 GLU A OE2   1 
ATOM 2307 N N     . SER D 2 233 ? 224.548 224.827 223.286 1.00 129.73 ? 245 SER A N     1 
ATOM 2308 C CA    . SER D 2 233 ? 224.850 223.556 223.934 1.00 129.73 ? 245 SER A CA    1 
ATOM 2309 C C     . SER D 2 233 ? 224.331 222.391 223.099 1.00 129.73 ? 245 SER A C     1 
ATOM 2310 O O     . SER D 2 233 ? 223.148 222.343 222.749 1.00 129.73 ? 245 SER A O     1 
ATOM 2311 C CB    . SER D 2 233 ? 224.240 223.525 225.334 1.00 129.73 ? 245 SER A CB    1 
ATOM 2312 O OG    . SER D 2 233 ? 222.828 223.447 225.270 1.00 129.73 ? 245 SER A OG    1 
ATOM 2313 N N     . ARG D 2 234 ? 225.224 221.452 222.777 1.00 137.57 ? 246 ARG A N     1 
ATOM 2314 C CA    . ARG D 2 234 ? 224.832 220.302 221.966 1.00 137.57 ? 246 ARG A CA    1 
ATOM 2315 C C     . ARG D 2 234 ? 223.948 219.346 222.756 1.00 137.57 ? 246 ARG A C     1 
ATOM 2316 O O     . ARG D 2 234 ? 222.922 218.874 222.252 1.00 137.57 ? 246 ARG A O     1 
ATOM 2317 C CB    . ARG D 2 234 ? 226.074 219.580 221.443 1.00 137.57 ? 246 ARG A CB    1 
ATOM 2318 C CG    . ARG D 2 234 ? 226.991 220.454 220.607 1.00 137.57 ? 246 ARG A CG    1 
ATOM 2319 C CD    . ARG D 2 234 ? 226.380 220.749 219.247 1.00 137.57 ? 246 ARG A CD    1 
ATOM 2320 N NE    . ARG D 2 234 ? 227.274 221.532 218.402 1.00 137.57 ? 246 ARG A NE    1 
ATOM 2321 C CZ    . ARG D 2 234 ? 227.280 222.857 218.348 1.00 137.57 ? 246 ARG A CZ    1 
ATOM 2322 N NH1   . ARG D 2 234 ? 226.450 223.582 219.079 1.00 137.57 ? 246 ARG A NH1   1 
ATOM 2323 N NH2   . ARG D 2 234 ? 228.140 223.469 217.539 1.00 137.57 ? 246 ARG A NH2   1 
ATOM 2324 N N     . ASN D 2 235 ? 224.326 219.051 223.999 1.00 138.28 ? 247 ASN A N     1 
ATOM 2325 C CA    . ASN D 2 235 ? 223.588 218.130 224.862 1.00 138.28 ? 247 ASN A CA    1 
ATOM 2326 C C     . ASN D 2 235 ? 223.283 218.848 226.170 1.00 138.28 ? 247 ASN A C     1 
ATOM 2327 O O     . ASN D 2 235 ? 223.928 218.598 227.197 1.00 138.28 ? 247 ASN A O     1 
ATOM 2328 C CB    . ASN D 2 235 ? 224.377 216.843 225.105 1.00 138.28 ? 247 ASN A CB    1 
ATOM 2329 C CG    . ASN D 2 235 ? 223.583 215.806 225.876 1.00 138.28 ? 247 ASN A CG    1 
ATOM 2330 O OD1   . ASN D 2 235 ? 222.605 216.126 226.548 1.00 138.28 ? 247 ASN A OD1   1 
ATOM 2331 N ND2   . ASN D 2 235 ? 224.005 214.551 225.781 1.00 138.28 ? 247 ASN A ND2   1 
ATOM 2332 N N     . PRO D 2 236 ? 222.303 219.748 226.166 1.00 134.83 ? 248 PRO A N     1 
ATOM 2333 C CA    . PRO D 2 236 ? 222.009 220.534 227.369 1.00 134.83 ? 248 PRO A CA    1 
ATOM 2334 C C     . PRO D 2 236 ? 221.533 219.684 228.538 1.00 134.83 ? 248 PRO A C     1 
ATOM 2335 O O     . PRO D 2 236 ? 220.916 218.630 228.368 1.00 134.83 ? 248 PRO A O     1 
ATOM 2336 C CB    . PRO D 2 236 ? 220.912 221.500 226.900 1.00 134.83 ? 248 PRO A CB    1 
ATOM 2337 C CG    . PRO D 2 236 ? 220.345 220.881 225.675 1.00 134.83 ? 248 PRO A CG    1 
ATOM 2338 C CD    . PRO D 2 236 ? 221.479 220.163 225.021 1.00 134.83 ? 248 PRO A CD    1 
ATOM 2339 N N     . GLY D 2 237 ? 221.837 220.165 229.746 1.00 129.56 ? 249 GLY A N     1 
ATOM 2340 C CA    . GLY D 2 237 ? 221.502 219.468 230.974 1.00 129.56 ? 249 GLY A CA    1 
ATOM 2341 C C     . GLY D 2 237 ? 221.056 220.351 232.126 1.00 129.56 ? 249 GLY A C     1 
ATOM 2342 O O     . GLY D 2 237 ? 220.243 221.260 231.942 1.00 129.56 ? 249 GLY A O     1 
ATOM 2343 N N     . ASN D 2 238 ? 221.596 220.094 233.323 1.00 133.22 ? 250 ASN A N     1 
ATOM 2344 C CA    . ASN D 2 238 ? 221.080 220.712 234.545 1.00 133.22 ? 250 ASN A CA    1 
ATOM 2345 C C     . ASN D 2 238 ? 221.499 222.175 234.684 1.00 133.22 ? 250 ASN A C     1 
ATOM 2346 O O     . ASN D 2 238 ? 220.701 223.009 235.136 1.00 133.22 ? 250 ASN A O     1 
ATOM 2347 C CB    . ASN D 2 238 ? 221.541 219.902 235.760 1.00 133.22 ? 250 ASN A CB    1 
ATOM 2348 C CG    . ASN D 2 238 ? 220.695 220.158 236.995 1.00 133.22 ? 250 ASN A CG    1 
ATOM 2349 O OD1   . ASN D 2 238 ? 219.956 221.138 237.067 1.00 133.22 ? 250 ASN A OD1   1 
ATOM 2350 N ND2   . ASN D 2 238 ? 220.800 219.268 237.976 1.00 133.22 ? 250 ASN A ND2   1 
ATOM 2351 N N     . ALA D 2 239 ? 222.741 222.508 234.328 1.00 128.37 ? 251 ALA A N     1 
ATOM 2352 C CA    . ALA D 2 239 ? 223.197 223.889 234.466 1.00 128.37 ? 251 ALA A CA    1 
ATOM 2353 C C     . ALA D 2 239 ? 222.387 224.819 233.573 1.00 128.37 ? 251 ALA A C     1 
ATOM 2354 O O     . ALA D 2 239 ? 221.884 225.856 234.018 1.00 128.37 ? 251 ALA A O     1 
ATOM 2355 C CB    . ALA D 2 239 ? 224.687 223.984 234.140 1.00 128.37 ? 251 ALA A CB    1 
ATOM 2356 N N     . GLU D 2 240 ? 222.224 224.447 232.307 1.00 127.27 ? 252 GLU A N     1 
ATOM 2357 C CA    . GLU D 2 240 ? 221.390 225.235 231.409 1.00 127.27 ? 252 GLU A CA    1 
ATOM 2358 C C     . GLU D 2 240 ? 219.901 224.984 231.634 1.00 127.27 ? 252 GLU A C     1 
ATOM 2359 O O     . GLU D 2 240 ? 219.072 225.782 231.188 1.00 127.27 ? 252 GLU A O     1 
ATOM 2360 C CB    . GLU D 2 240 ? 221.814 225.001 229.955 1.00 127.27 ? 252 GLU A CB    1 
ATOM 2361 C CG    . GLU D 2 240 ? 223.212 225.463 229.534 1.00 127.27 ? 252 GLU A CG    1 
ATOM 2362 C CD    . GLU D 2 240 ? 224.320 224.442 229.828 1.00 127.27 ? 252 GLU A CD    1 
ATOM 2363 O OE1   . GLU D 2 240 ? 224.008 223.387 230.418 1.00 127.27 ? 252 GLU A OE1   1 
ATOM 2364 O OE2   . GLU D 2 240 ? 225.498 224.686 229.499 1.00 127.27 ? 252 GLU A OE2   1 
ATOM 2365 N N     . PHE D 2 241 ? 219.543 223.923 232.360 1.00 124.98 ? 253 PHE A N     1 
ATOM 2366 C CA    . PHE D 2 241 ? 218.213 223.853 232.963 1.00 124.98 ? 253 PHE A CA    1 
ATOM 2367 C C     . PHE D 2 241 ? 217.970 225.067 233.855 1.00 124.98 ? 253 PHE A C     1 
ATOM 2368 O O     . PHE D 2 241 ? 216.971 225.786 233.702 1.00 124.98 ? 253 PHE A O     1 
ATOM 2369 C CB    . PHE D 2 241 ? 218.099 222.546 233.756 1.00 124.98 ? 253 PHE A CB    1 
ATOM 2370 C CG    . PHE D 2 241 ? 216.711 222.190 234.225 1.00 124.98 ? 253 PHE A CG    1 
ATOM 2371 C CD1   . PHE D 2 241 ? 216.003 223.015 235.083 1.00 124.98 ? 253 PHE A CD1   1 
ATOM 2372 C CD2   . PHE D 2 241 ? 216.153 220.975 233.868 1.00 124.98 ? 253 PHE A CD2   1 
ATOM 2373 C CE1   . PHE D 2 241 ? 214.746 222.658 235.528 1.00 124.98 ? 253 PHE A CE1   1 
ATOM 2374 C CE2   . PHE D 2 241 ? 214.899 220.614 234.311 1.00 124.98 ? 253 PHE A CE2   1 
ATOM 2375 C CZ    . PHE D 2 241 ? 214.198 221.455 235.148 1.00 124.98 ? 253 PHE A CZ    1 
ATOM 2376 N N     . GLU D 2 242 ? 218.897 225.330 234.780 1.00 125.08 ? 254 GLU A N     1 
ATOM 2377 C CA    . GLU D 2 242 ? 218.758 226.511 235.626 1.00 125.08 ? 254 GLU A CA    1 
ATOM 2378 C C     . GLU D 2 242 ? 218.926 227.790 234.814 1.00 125.08 ? 254 GLU A C     1 
ATOM 2379 O O     . GLU D 2 242 ? 218.338 228.821 235.155 1.00 125.08 ? 254 GLU A O     1 
ATOM 2380 C CB    . GLU D 2 242 ? 219.750 226.436 236.798 1.00 125.08 ? 254 GLU A CB    1 
ATOM 2381 C CG    . GLU D 2 242 ? 219.520 225.333 237.847 1.00 125.08 ? 254 GLU A CG    1 
ATOM 2382 C CD    . GLU D 2 242 ? 220.577 225.275 238.935 1.00 125.08 ? 254 GLU A CD    1 
ATOM 2383 O OE1   . GLU D 2 242 ? 221.609 225.963 238.790 1.00 125.08 ? 254 GLU A OE1   1 
ATOM 2384 O OE2   . GLU D 2 242 ? 220.370 224.562 239.938 1.00 125.08 ? 254 GLU A OE2   1 
ATOM 2385 N N     . ASP D 2 243 ? 219.720 227.743 233.741 1.00 121.42 ? 255 ASP A N     1 
ATOM 2386 C CA    . ASP D 2 243 ? 219.847 228.904 232.862 1.00 121.42 ? 255 ASP A CA    1 
ATOM 2387 C C     . ASP D 2 243 ? 218.508 229.270 232.233 1.00 121.42 ? 255 ASP A C     1 
ATOM 2388 O O     . ASP D 2 243 ? 218.142 230.448 232.177 1.00 121.42 ? 255 ASP A O     1 
ATOM 2389 C CB    . ASP D 2 243 ? 220.878 228.638 231.767 1.00 121.42 ? 255 ASP A CB    1 
ATOM 2390 C CG    . ASP D 2 243 ? 222.301 228.783 232.255 1.00 121.42 ? 255 ASP A CG    1 
ATOM 2391 O OD1   . ASP D 2 243 ? 222.502 229.363 233.339 1.00 121.42 ? 255 ASP A OD1   1 
ATOM 2392 O OD2   . ASP D 2 243 ? 223.222 228.319 231.550 1.00 121.42 ? 255 ASP A OD2   1 
ATOM 2393 N N     . LEU D 2 244 ? 217.765 228.274 231.746 1.00 115.85 ? 256 LEU A N     1 
ATOM 2394 C CA    . LEU D 2 244 ? 216.444 228.539 231.188 1.00 115.85 ? 256 LEU A CA    1 
ATOM 2395 C C     . LEU D 2 244 ? 215.461 228.979 232.264 1.00 115.85 ? 256 LEU A C     1 
ATOM 2396 O O     . LEU D 2 244 ? 214.598 229.830 232.005 1.00 115.85 ? 256 LEU A O     1 
ATOM 2397 C CB    . LEU D 2 244 ? 215.919 227.304 230.460 1.00 115.85 ? 256 LEU A CB    1 
ATOM 2398 C CG    . LEU D 2 244 ? 216.602 226.966 229.136 1.00 115.85 ? 256 LEU A CG    1 
ATOM 2399 C CD1   . LEU D 2 244 ? 216.155 225.602 228.638 1.00 115.85 ? 256 LEU A CD1   1 
ATOM 2400 C CD2   . LEU D 2 244 ? 216.312 228.040 228.101 1.00 115.85 ? 256 LEU A CD2   1 
ATOM 2401 N N     . ILE D 2 245 ? 215.570 228.415 233.471 1.00 113.04 ? 257 ILE A N     1 
ATOM 2402 C CA    . ILE D 2 245 ? 214.741 228.895 234.575 1.00 113.04 ? 257 ILE A CA    1 
ATOM 2403 C C     . ILE D 2 245 ? 214.997 230.376 234.826 1.00 113.04 ? 257 ILE A C     1 
ATOM 2404 O O     . ILE D 2 245 ? 214.060 231.161 235.009 1.00 113.04 ? 257 ILE A O     1 
ATOM 2405 C CB    . ILE D 2 245 ? 214.984 228.059 235.845 1.00 113.04 ? 257 ILE A CB    1 
ATOM 2406 C CG1   . ILE D 2 245 ? 214.329 226.685 235.723 1.00 113.04 ? 257 ILE A CG1   1 
ATOM 2407 C CG2   . ILE D 2 245 ? 214.459 228.786 237.075 1.00 113.04 ? 257 ILE A CG2   1 
ATOM 2408 C CD1   . ILE D 2 245 ? 214.592 225.794 236.912 1.00 113.04 ? 257 ILE A CD1   1 
ATOM 2409 N N     . PHE D 2 246 ? 216.268 230.780 234.832 1.00 111.36 ? 258 PHE A N     1 
ATOM 2410 C CA    . PHE D 2 246 ? 216.612 232.186 235.025 1.00 111.36 ? 258 PHE A CA    1 
ATOM 2411 C C     . PHE D 2 246 ? 216.131 233.044 233.861 1.00 111.36 ? 258 PHE A C     1 
ATOM 2412 O O     . PHE D 2 246 ? 215.693 234.184 234.059 1.00 111.36 ? 258 PHE A O     1 
ATOM 2413 C CB    . PHE D 2 246 ? 218.122 232.330 235.211 1.00 111.36 ? 258 PHE A CB    1 
ATOM 2414 C CG    . PHE D 2 246 ? 218.576 233.746 235.422 1.00 111.36 ? 258 PHE A CG    1 
ATOM 2415 C CD1   . PHE D 2 246 ? 218.420 234.361 236.652 1.00 111.36 ? 258 PHE A CD1   1 
ATOM 2416 C CD2   . PHE D 2 246 ? 219.168 234.457 234.392 1.00 111.36 ? 258 PHE A CD2   1 
ATOM 2417 C CE1   . PHE D 2 246 ? 218.839 235.662 236.849 1.00 111.36 ? 258 PHE A CE1   1 
ATOM 2418 C CE2   . PHE D 2 246 ? 219.589 235.758 234.584 1.00 111.36 ? 258 PHE A CE2   1 
ATOM 2419 C CZ    . PHE D 2 246 ? 219.425 236.361 235.814 1.00 111.36 ? 258 PHE A CZ    1 
ATOM 2420 N N     . LEU D 2 247 ? 216.229 232.525 232.637 1.00 107.91 ? 259 LEU A N     1 
ATOM 2421 C CA    . LEU D 2 247 ? 215.808 233.290 231.469 1.00 107.91 ? 259 LEU A CA    1 
ATOM 2422 C C     . LEU D 2 247 ? 214.312 233.569 231.499 1.00 107.91 ? 259 LEU A C     1 
ATOM 2423 O O     . LEU D 2 247 ? 213.878 234.686 231.195 1.00 107.91 ? 259 LEU A O     1 
ATOM 2424 C CB    . LEU D 2 247 ? 216.190 232.547 230.192 1.00 107.91 ? 259 LEU A CB    1 
ATOM 2425 C CG    . LEU D 2 247 ? 216.298 233.399 228.930 1.00 107.91 ? 259 LEU A CG    1 
ATOM 2426 C CD1   . LEU D 2 247 ? 217.011 234.711 229.220 1.00 107.91 ? 259 LEU A CD1   1 
ATOM 2427 C CD2   . LEU D 2 247 ? 217.023 232.620 227.857 1.00 107.91 ? 259 LEU A CD2   1 
ATOM 2428 N N     . ALA D 2 248 ? 213.508 232.565 231.854 1.00 103.30 ? 260 ALA A N     1 
ATOM 2429 C CA    . ALA D 2 248 ? 212.087 232.816 232.075 1.00 103.30 ? 260 ALA A CA    1 
ATOM 2430 C C     . ALA D 2 248 ? 211.883 233.728 233.277 1.00 103.30 ? 260 ALA A C     1 
ATOM 2431 O O     . ALA D 2 248 ? 210.949 234.537 233.308 1.00 103.30 ? 260 ALA A O     1 
ATOM 2432 C CB    . ALA D 2 248 ? 211.340 231.498 232.268 1.00 103.30 ? 260 ALA A CB    1 
ATOM 2433 N N     . ARG D 2 249 ? 212.756 233.602 234.277 1.00 105.22 ? 261 ARG A N     1 
ATOM 2434 C CA    . ARG D 2 249 ? 212.680 234.422 235.479 1.00 105.22 ? 261 ARG A CA    1 
ATOM 2435 C C     . ARG D 2 249 ? 212.907 235.891 235.141 1.00 105.22 ? 261 ARG A C     1 
ATOM 2436 O O     . ARG D 2 249 ? 212.208 236.767 235.662 1.00 105.22 ? 261 ARG A O     1 
ATOM 2437 C CB    . ARG D 2 249 ? 213.725 233.902 236.473 1.00 105.22 ? 261 ARG A CB    1 
ATOM 2438 C CG    . ARG D 2 249 ? 213.849 234.541 237.852 1.00 105.22 ? 261 ARG A CG    1 
ATOM 2439 C CD    . ARG D 2 249 ? 212.575 234.530 238.671 1.00 105.22 ? 261 ARG A CD    1 
ATOM 2440 N NE    . ARG D 2 249 ? 212.103 233.160 238.823 1.00 105.22 ? 261 ARG A NE    1 
ATOM 2441 C CZ    . ARG D 2 249 ? 212.513 232.315 239.757 1.00 105.22 ? 261 ARG A CZ    1 
ATOM 2442 N NH1   . ARG D 2 249 ? 213.434 232.656 240.645 1.00 105.22 ? 261 ARG A NH1   1 
ATOM 2443 N NH2   . ARG D 2 249 ? 211.975 231.101 239.811 1.00 105.22 ? 261 ARG A NH2   1 
ATOM 2444 N N     . SER D 2 250 ? 213.863 236.173 234.252 1.00 101.18 ? 262 SER A N     1 
ATOM 2445 C CA    . SER D 2 250 ? 214.154 237.545 233.853 1.00 101.18 ? 262 SER A CA    1 
ATOM 2446 C C     . SER D 2 250 ? 213.059 238.151 232.985 1.00 101.18 ? 262 SER A C     1 
ATOM 2447 O O     . SER D 2 250 ? 212.994 239.379 232.863 1.00 101.18 ? 262 SER A O     1 
ATOM 2448 C CB    . SER D 2 250 ? 215.489 237.600 233.110 1.00 101.18 ? 262 SER A CB    1 
ATOM 2449 O OG    . SER D 2 250 ? 215.397 236.956 231.851 1.00 101.18 ? 262 SER A OG    1 
ATOM 2450 N N     . ALA D 2 251 ? 212.200 237.328 232.380 1.00 99.00  ? 263 ALA A N     1 
ATOM 2451 C CA    . ALA D 2 251 ? 211.139 237.852 231.529 1.00 99.00  ? 263 ALA A CA    1 
ATOM 2452 C C     . ALA D 2 251 ? 210.075 238.608 232.311 1.00 99.00  ? 263 ALA A C     1 
ATOM 2453 O O     . ALA D 2 251 ? 209.316 239.374 231.708 1.00 99.00  ? 263 ALA A O     1 
ATOM 2454 C CB    . ALA D 2 251 ? 210.488 236.716 230.739 1.00 99.00  ? 263 ALA A CB    1 
ATOM 2455 N N     . LEU D 2 252 ? 209.998 238.414 233.628 1.00 97.77  ? 264 LEU A N     1 
ATOM 2456 C CA    . LEU D 2 252 ? 209.042 239.168 234.430 1.00 97.77  ? 264 LEU A CA    1 
ATOM 2457 C C     . LEU D 2 252 ? 209.416 240.641 234.512 1.00 97.77  ? 264 LEU A C     1 
ATOM 2458 O O     . LEU D 2 252 ? 208.541 241.490 234.716 1.00 97.77  ? 264 LEU A O     1 
ATOM 2459 C CB    . LEU D 2 252 ? 208.944 238.569 235.832 1.00 97.77  ? 264 LEU A CB    1 
ATOM 2460 C CG    . LEU D 2 252 ? 208.338 237.170 235.935 1.00 97.77  ? 264 LEU A CG    1 
ATOM 2461 C CD1   . LEU D 2 252 ? 208.650 236.551 237.286 1.00 97.77  ? 264 LEU A CD1   1 
ATOM 2462 C CD2   . LEU D 2 252 ? 206.838 237.230 235.704 1.00 97.77  ? 264 LEU A CD2   1 
ATOM 2463 N N     . ILE D 2 253 ? 210.695 240.963 234.357 1.00 101.41 ? 265 ILE A N     1 
ATOM 2464 C CA    . ILE D 2 253 ? 211.179 242.333 234.475 1.00 101.41 ? 265 ILE A CA    1 
ATOM 2465 C C     . ILE D 2 253 ? 211.465 242.941 233.105 1.00 101.41 ? 265 ILE A C     1 
ATOM 2466 O O     . ILE D 2 253 ? 210.994 244.035 232.793 1.00 101.41 ? 265 ILE A O     1 
ATOM 2467 C CB    . ILE D 2 253 ? 212.424 242.375 235.388 1.00 101.41 ? 265 ILE A CB    1 
ATOM 2468 C CG1   . ILE D 2 253 ? 212.004 242.529 236.849 1.00 101.41 ? 265 ILE A CG1   1 
ATOM 2469 C CG2   . ILE D 2 253 ? 213.305 243.544 235.030 1.00 101.41 ? 265 ILE A CG2   1 
ATOM 2470 C CD1   . ILE D 2 253 ? 211.284 243.817 237.141 1.00 101.41 ? 265 ILE A CD1   1 
ATOM 2471 N N     . LEU D 2 254 ? 212.239 242.244 232.272 1.00 101.43 ? 266 LEU A N     1 
ATOM 2472 C CA    . LEU D 2 254 ? 212.423 242.603 230.863 1.00 101.43 ? 266 LEU A CA    1 
ATOM 2473 C C     . LEU D 2 254 ? 211.682 241.567 230.026 1.00 101.43 ? 266 LEU A C     1 
ATOM 2474 O O     . LEU D 2 254 ? 212.204 240.494 229.725 1.00 101.43 ? 266 LEU A O     1 
ATOM 2475 C CB    . LEU D 2 254 ? 213.898 242.671 230.480 1.00 101.43 ? 266 LEU A CB    1 
ATOM 2476 C CG    . LEU D 2 254 ? 214.964 243.058 231.500 1.00 101.43 ? 266 LEU A CG    1 
ATOM 2477 C CD1   . LEU D 2 254 ? 216.329 242.998 230.848 1.00 101.43 ? 266 LEU A CD1   1 
ATOM 2478 C CD2   . LEU D 2 254 ? 214.701 244.467 231.985 1.00 101.43 ? 266 LEU A CD2   1 
ATOM 2479 N N     . ARG D 2 255 ? 210.452 241.897 229.648 1.00 96.97  ? 267 ARG A N     1 
ATOM 2480 C CA    . ARG D 2 255 ? 209.627 240.960 228.902 1.00 96.97  ? 267 ARG A CA    1 
ATOM 2481 C C     . ARG D 2 255 ? 210.000 240.947 227.427 1.00 96.97  ? 267 ARG A C     1 
ATOM 2482 O O     . ARG D 2 255 ? 210.590 241.894 226.899 1.00 96.97  ? 267 ARG A O     1 
ATOM 2483 C CB    . ARG D 2 255 ? 208.153 241.318 229.043 1.00 96.97  ? 267 ARG A CB    1 
ATOM 2484 C CG    . ARG D 2 255 ? 207.841 242.113 230.278 1.00 96.97  ? 267 ARG A CG    1 
ATOM 2485 C CD    . ARG D 2 255 ? 206.357 242.365 230.380 1.00 96.97  ? 267 ARG A CD    1 
ATOM 2486 N NE    . ARG D 2 255 ? 206.077 243.525 231.212 1.00 96.97  ? 267 ARG A NE    1 
ATOM 2487 C CZ    . ARG D 2 255 ? 206.245 243.562 232.526 1.00 96.97  ? 267 ARG A CZ    1 
ATOM 2488 N NH1   . ARG D 2 255 ? 206.653 242.502 233.204 1.00 96.97  ? 267 ARG A NH1   1 
ATOM 2489 N NH2   . ARG D 2 255 ? 205.987 244.689 233.177 1.00 96.97  ? 267 ARG A NH2   1 
ATOM 2490 N N     . GLY D 2 256 ? 209.642 239.851 226.760 1.00 90.48  ? 268 GLY A N     1 
ATOM 2491 C CA    . GLY D 2 256 ? 209.766 239.759 225.324 1.00 90.48  ? 268 GLY A CA    1 
ATOM 2492 C C     . GLY D 2 256 ? 208.548 240.323 224.617 1.00 90.48  ? 268 GLY A C     1 
ATOM 2493 O O     . GLY D 2 256 ? 207.608 240.827 225.229 1.00 90.48  ? 268 GLY A O     1 
ATOM 2494 N N     . SER D 2 257 ? 208.578 240.233 223.292 1.00 85.95  ? 269 SER A N     1 
ATOM 2495 C CA    . SER D 2 257 ? 207.483 240.714 222.458 1.00 85.95  ? 269 SER A CA    1 
ATOM 2496 C C     . SER D 2 257 ? 206.510 239.565 222.222 1.00 85.95  ? 269 SER A C     1 
ATOM 2497 O O     . SER D 2 257 ? 206.819 238.620 221.489 1.00 85.95  ? 269 SER A O     1 
ATOM 2498 C CB    . SER D 2 257 ? 208.013 241.271 221.140 1.00 85.95  ? 269 SER A CB    1 
ATOM 2499 O OG    . SER D 2 257 ? 206.967 241.838 220.372 1.00 85.95  ? 269 SER A OG    1 
ATOM 2500 N N     . VAL D 2 258 ? 205.336 239.646 222.840 1.00 78.05  ? 270 VAL A N     1 
ATOM 2501 C CA    . VAL D 2 258 ? 204.308 238.618 222.730 1.00 78.05  ? 270 VAL A CA    1 
ATOM 2502 C C     . VAL D 2 258 ? 203.101 239.238 222.043 1.00 78.05  ? 270 VAL A C     1 
ATOM 2503 O O     . VAL D 2 258 ? 202.576 240.260 222.501 1.00 78.05  ? 270 VAL A O     1 
ATOM 2504 C CB    . VAL D 2 258 ? 203.925 238.044 224.103 1.00 78.05  ? 270 VAL A CB    1 
ATOM 2505 C CG1   . VAL D 2 258 ? 202.636 237.247 224.004 1.00 78.05  ? 270 VAL A CG1   1 
ATOM 2506 C CG2   . VAL D 2 258 ? 205.052 237.181 224.646 1.00 78.05  ? 270 VAL A CG2   1 
ATOM 2507 N N     . ALA D 2 259 ? 202.665 238.623 220.947 1.00 75.18  ? 271 ALA A N     1 
ATOM 2508 C CA    . ALA D 2 259 ? 201.551 239.159 220.181 1.00 75.18  ? 271 ALA A CA    1 
ATOM 2509 C C     . ALA D 2 259 ? 200.242 239.000 220.942 1.00 75.18  ? 271 ALA A C     1 
ATOM 2510 O O     . ALA D 2 259 ? 200.036 238.019 221.662 1.00 75.18  ? 271 ALA A O     1 
ATOM 2511 C CB    . ALA D 2 259 ? 201.456 238.463 218.824 1.00 75.18  ? 271 ALA A CB    1 
ATOM 2512 N N     . HIS D 2 260 ? 199.368 240.001 220.772 1.00 72.38  ? 272 HIS A N     1 
ATOM 2513 C CA    . HIS D 2 260 ? 198.024 239.973 221.408 1.00 72.38  ? 272 HIS A CA    1 
ATOM 2514 C C     . HIS D 2 260 ? 196.983 240.183 220.306 1.00 72.38  ? 272 HIS A C     1 
ATOM 2515 O O     . HIS D 2 260 ? 197.058 241.221 219.620 1.00 72.38  ? 272 HIS A O     1 
ATOM 2516 C CB    . HIS D 2 260 ? 197.947 241.003 222.541 1.00 72.38  ? 272 HIS A CB    1 
ATOM 2517 C CG    . HIS D 2 260 ? 198.992 240.783 223.580 1.00 72.38  ? 272 HIS A CG    1 
ATOM 2518 N ND1   . HIS D 2 260 ? 198.833 239.873 224.606 1.00 72.38  ? 272 HIS A ND1   1 
ATOM 2519 C CD2   . HIS D 2 260 ? 200.219 241.322 223.739 1.00 72.38  ? 272 HIS A CD2   1 
ATOM 2520 C CE1   . HIS D 2 260 ? 199.911 239.876 225.363 1.00 72.38  ? 272 HIS A CE1   1 
ATOM 2521 N NE2   . HIS D 2 260 ? 200.779 240.749 224.846 1.00 72.38  ? 272 HIS A NE2   1 
ATOM 2522 N N     . LYS D 2 261 ? 196.056 239.240 220.143 1.00 71.00  ? 273 LYS A N     1 
ATOM 2523 C CA    . LYS D 2 261 ? 195.072 239.278 219.073 1.00 71.00  ? 273 LYS A CA    1 
ATOM 2524 C C     . LYS D 2 261 ? 193.670 239.135 219.643 1.00 71.00  ? 273 LYS A C     1 
ATOM 2525 O O     . LYS D 2 261 ? 193.465 238.512 220.688 1.00 71.00  ? 273 LYS A O     1 
ATOM 2526 C CB    . LYS D 2 261 ? 195.321 238.170 218.040 1.00 71.00  ? 273 LYS A CB    1 
ATOM 2527 C CG    . LYS D 2 261 ? 196.600 238.342 217.246 1.00 71.00  ? 273 LYS A CG    1 
ATOM 2528 C CD    . LYS D 2 261 ? 196.794 237.206 216.267 1.00 71.00  ? 273 LYS A CD    1 
ATOM 2529 C CE    . LYS D 2 261 ? 198.063 237.399 215.460 1.00 71.00  ? 273 LYS A CE    1 
ATOM 2530 N NZ    . LYS D 2 261 ? 198.280 236.278 214.510 1.00 71.00  ? 273 LYS A NZ    1 
ATOM 2531 N N     . SER D 2 262 ? 192.703 239.724 218.941 1.00 68.85  ? 274 SER A N     1 
ATOM 2532 C CA    . SER D 2 262 ? 191.293 239.633 219.317 1.00 68.85  ? 274 SER A CA    1 
ATOM 2533 C C     . SER D 2 262 ? 190.666 238.495 218.524 1.00 68.85  ? 274 SER A C     1 
ATOM 2534 O O     . SER D 2 262 ? 190.181 238.680 217.407 1.00 68.85  ? 274 SER A O     1 
ATOM 2535 C CB    . SER D 2 262 ? 190.576 240.951 219.058 1.00 68.85  ? 274 SER A CB    1 
ATOM 2536 O OG    . SER D 2 262 ? 191.396 242.055 219.387 1.00 68.85  ? 274 SER A OG    1 
ATOM 2537 N N     . CYS D 2 263 ? 190.675 237.301 219.107 1.00 69.36  ? 275 CYS A N     1 
ATOM 2538 C CA    . CYS D 2 263 ? 190.098 236.116 218.477 1.00 69.36  ? 275 CYS A CA    1 
ATOM 2539 C C     . CYS D 2 263 ? 188.695 235.914 219.038 1.00 69.36  ? 275 CYS A C     1 
ATOM 2540 O O     . CYS D 2 263 ? 188.520 235.356 220.124 1.00 69.36  ? 275 CYS A O     1 
ATOM 2541 C CB    . CYS D 2 263 ? 190.982 234.897 218.706 1.00 69.36  ? 275 CYS A CB    1 
ATOM 2542 S SG    . CYS D 2 263 ? 192.485 234.900 217.708 1.00 69.36  ? 275 CYS A SG    1 
ATOM 2543 N N     . LEU D 2 264 ? 187.697 236.372 218.292 1.00 68.54  ? 276 LEU A N     1 
ATOM 2544 C CA    . LEU D 2 264 ? 186.307 236.248 218.692 1.00 68.54  ? 276 LEU A CA    1 
ATOM 2545 C C     . LEU D 2 264 ? 185.803 234.826 218.458 1.00 68.54  ? 276 LEU A C     1 
ATOM 2546 O O     . LEU D 2 264 ? 186.353 234.089 217.636 1.00 68.54  ? 276 LEU A O     1 
ATOM 2547 C CB    . LEU D 2 264 ? 185.453 237.245 217.915 1.00 68.54  ? 276 LEU A CB    1 
ATOM 2548 C CG    . LEU D 2 264 ? 185.780 238.728 218.104 1.00 68.54  ? 276 LEU A CG    1 
ATOM 2549 C CD1   . LEU D 2 264 ? 184.642 239.593 217.594 1.00 68.54  ? 276 LEU A CD1   1 
ATOM 2550 C CD2   . LEU D 2 264 ? 186.072 239.034 219.563 1.00 68.54  ? 276 LEU A CD2   1 
ATOM 2551 N N     . PRO D 2 265 ? 184.762 234.411 219.176 1.00 69.15  ? 277 PRO A N     1 
ATOM 2552 C CA    . PRO D 2 265 ? 184.181 233.088 218.930 1.00 69.15  ? 277 PRO A CA    1 
ATOM 2553 C C     . PRO D 2 265 ? 183.476 233.035 217.585 1.00 69.15  ? 277 PRO A C     1 
ATOM 2554 O O     . PRO D 2 265 ? 183.099 234.055 217.004 1.00 69.15  ? 277 PRO A O     1 
ATOM 2555 C CB    . PRO D 2 265 ? 183.188 232.912 220.084 1.00 69.15  ? 277 PRO A CB    1 
ATOM 2556 C CG    . PRO D 2 265 ? 182.848 234.298 220.498 1.00 69.15  ? 277 PRO A CG    1 
ATOM 2557 C CD    . PRO D 2 265 ? 184.097 235.102 220.294 1.00 69.15  ? 277 PRO A CD    1 
ATOM 2558 N N     . ALA D 2 266 ? 183.303 231.808 217.089 1.00 71.37  ? 278 ALA A N     1 
ATOM 2559 C CA    . ALA D 2 266 ? 182.652 231.611 215.799 1.00 71.37  ? 278 ALA A CA    1 
ATOM 2560 C C     . ALA D 2 266 ? 181.209 232.094 215.797 1.00 71.37  ? 278 ALA A C     1 
ATOM 2561 O O     . ALA D 2 266 ? 180.657 232.355 214.723 1.00 71.37  ? 278 ALA A O     1 
ATOM 2562 C CB    . ALA D 2 266 ? 182.708 230.135 215.402 1.00 71.37  ? 278 ALA A CB    1 
ATOM 2563 N N     . CYS D 2 267 ? 180.587 232.217 216.972 1.00 72.50  ? 279 CYS A N     1 
ATOM 2564 C CA    . CYS D 2 267 ? 179.220 232.724 217.041 1.00 72.50  ? 279 CYS A CA    1 
ATOM 2565 C C     . CYS D 2 267 ? 179.127 234.160 216.541 1.00 72.50  ? 279 CYS A C     1 
ATOM 2566 O O     . CYS D 2 267 ? 178.206 234.505 215.790 1.00 72.50  ? 279 CYS A O     1 
ATOM 2567 C CB    . CYS D 2 267 ? 178.702 232.628 218.473 1.00 72.50  ? 279 CYS A CB    1 
ATOM 2568 S SG    . CYS D 2 267 ? 177.048 233.302 218.691 1.00 72.50  ? 279 CYS A SG    1 
ATOM 2569 N N     . VAL D 2 268 ? 180.066 235.014 216.954 1.00 71.98  ? 280 VAL A N     1 
ATOM 2570 C CA    . VAL D 2 268 ? 180.033 236.413 216.536 1.00 71.98  ? 280 VAL A CA    1 
ATOM 2571 C C     . VAL D 2 268 ? 180.231 236.526 215.031 1.00 71.98  ? 280 VAL A C     1 
ATOM 2572 O O     . VAL D 2 268 ? 179.533 237.291 214.353 1.00 71.98  ? 280 VAL A O     1 
ATOM 2573 C CB    . VAL D 2 268 ? 181.087 237.227 217.308 1.00 71.98  ? 280 VAL A CB    1 
ATOM 2574 C CG1   . VAL D 2 268 ? 180.939 238.706 217.001 1.00 71.98  ? 280 VAL A CG1   1 
ATOM 2575 C CG2   . VAL D 2 268 ? 180.962 236.974 218.799 1.00 71.98  ? 280 VAL A CG2   1 
ATOM 2576 N N     . TYR D 2 269 ? 181.187 235.771 214.484 1.00 72.39  ? 281 TYR A N     1 
ATOM 2577 C CA    . TYR D 2 269 ? 181.416 235.796 213.043 1.00 72.39  ? 281 TYR A CA    1 
ATOM 2578 C C     . TYR D 2 269 ? 180.202 235.278 212.281 1.00 72.39  ? 281 TYR A C     1 
ATOM 2579 O O     . TYR D 2 269 ? 179.829 235.833 211.240 1.00 72.39  ? 281 TYR A O     1 
ATOM 2580 C CB    . TYR D 2 269 ? 182.657 234.976 212.694 1.00 72.39  ? 281 TYR A CB    1 
ATOM 2581 C CG    . TYR D 2 269 ? 183.921 235.456 213.370 1.00 72.39  ? 281 TYR A CG    1 
ATOM 2582 C CD1   . TYR D 2 269 ? 184.188 236.811 213.503 1.00 72.39  ? 281 TYR A CD1   1 
ATOM 2583 C CD2   . TYR D 2 269 ? 184.848 234.554 213.871 1.00 72.39  ? 281 TYR A CD2   1 
ATOM 2584 C CE1   . TYR D 2 269 ? 185.343 237.253 214.117 1.00 72.39  ? 281 TYR A CE1   1 
ATOM 2585 C CE2   . TYR D 2 269 ? 186.005 234.987 214.487 1.00 72.39  ? 281 TYR A CE2   1 
ATOM 2586 C CZ    . TYR D 2 269 ? 186.247 236.337 214.608 1.00 72.39  ? 281 TYR A CZ    1 
ATOM 2587 O OH    . TYR D 2 269 ? 187.398 236.773 215.221 1.00 72.39  ? 281 TYR A OH    1 
ATOM 2588 N N     . GLY D 2 270 ? 179.578 234.209 212.780 1.00 73.14  ? 282 GLY A N     1 
ATOM 2589 C CA    . GLY D 2 270 ? 178.387 233.692 212.128 1.00 73.14  ? 282 GLY A CA    1 
ATOM 2590 C C     . GLY D 2 270 ? 177.241 234.684 212.135 1.00 73.14  ? 282 GLY A C     1 
ATOM 2591 O O     . GLY D 2 270 ? 176.542 234.846 211.133 1.00 73.14  ? 282 GLY A O     1 
ATOM 2592 N N     . SER D 2 271 ? 177.033 235.361 213.267 1.00 72.24  ? 283 SER A N     1 
ATOM 2593 C CA    . SER D 2 271 ? 175.995 236.385 213.331 1.00 72.24  ? 283 SER A CA    1 
ATOM 2594 C C     . SER D 2 271 ? 176.305 237.543 212.390 1.00 72.24  ? 283 SER A C     1 
ATOM 2595 O O     . SER D 2 271 ? 175.404 238.073 211.729 1.00 72.24  ? 283 SER A O     1 
ATOM 2596 C CB    . SER D 2 271 ? 175.839 236.887 214.767 1.00 72.24  ? 283 SER A CB    1 
ATOM 2597 O OG    . SER D 2 271 ? 174.860 237.908 214.846 1.00 72.24  ? 283 SER A OG    1 
ATOM 2598 N N     . ALA D 2 272 ? 177.574 237.953 212.321 1.00 71.48  ? 284 ALA A N     1 
ATOM 2599 C CA    . ALA D 2 272 ? 177.955 239.045 211.431 1.00 71.48  ? 284 ALA A CA    1 
ATOM 2600 C C     . ALA D 2 272 ? 177.715 238.682 209.973 1.00 71.48  ? 284 ALA A C     1 
ATOM 2601 O O     . ALA D 2 272 ? 177.222 239.506 209.193 1.00 71.48  ? 284 ALA A O     1 
ATOM 2602 C CB    . ALA D 2 272 ? 179.419 239.415 211.654 1.00 71.48  ? 284 ALA A CB    1 
ATOM 2603 N N     . VAL D 2 273 ? 178.064 237.455 209.583 1.00 73.33  ? 285 VAL A N     1 
ATOM 2604 C CA    . VAL D 2 273 ? 177.835 237.023 208.208 1.00 73.33  ? 285 VAL A CA    1 
ATOM 2605 C C     . VAL D 2 273 ? 176.341 236.905 207.928 1.00 73.33  ? 285 VAL A C     1 
ATOM 2606 O O     . VAL D 2 273 ? 175.869 237.262 206.842 1.00 73.33  ? 285 VAL A O     1 
ATOM 2607 C CB    . VAL D 2 273 ? 178.579 235.704 207.934 1.00 73.33  ? 285 VAL A CB    1 
ATOM 2608 C CG1   . VAL D 2 273 ? 178.130 235.099 206.615 1.00 73.33  ? 285 VAL A CG1   1 
ATOM 2609 C CG2   . VAL D 2 273 ? 180.080 235.942 207.929 1.00 73.33  ? 285 VAL A CG2   1 
ATOM 2610 N N     . ALA D 2 274 ? 175.572 236.415 208.904 1.00 73.41  ? 286 ALA A N     1 
ATOM 2611 C CA    . ALA D 2 274 ? 174.124 236.336 208.739 1.00 73.41  ? 286 ALA A CA    1 
ATOM 2612 C C     . ALA D 2 274 ? 173.500 237.716 208.583 1.00 73.41  ? 286 ALA A C     1 
ATOM 2613 O O     . ALA D 2 274 ? 172.458 237.856 207.932 1.00 73.41  ? 286 ALA A O     1 
ATOM 2614 C CB    . ALA D 2 274 ? 173.499 235.602 209.925 1.00 73.41  ? 286 ALA A CB    1 
ATOM 2615 N N     . SER D 2 275 ? 174.116 238.743 209.170 1.00 74.06  ? 287 SER A N     1 
ATOM 2616 C CA    . SER D 2 275 ? 173.631 240.106 209.000 1.00 74.06  ? 287 SER A CA    1 
ATOM 2617 C C     . SER D 2 275 ? 173.958 240.677 207.628 1.00 74.06  ? 287 SER A C     1 
ATOM 2618 O O     . SER D 2 275 ? 173.443 241.746 207.283 1.00 74.06  ? 287 SER A O     1 
ATOM 2619 C CB    . SER D 2 275 ? 174.215 241.011 210.086 1.00 74.06  ? 287 SER A CB    1 
ATOM 2620 O OG    . SER D 2 275 ? 173.750 240.632 211.370 1.00 74.06  ? 287 SER A OG    1 
ATOM 2621 N N     . GLY D 2 276 ? 174.795 240.000 206.845 1.00 73.70  ? 288 GLY A N     1 
ATOM 2622 C CA    . GLY D 2 276 ? 175.164 240.462 205.525 1.00 73.70  ? 288 GLY A CA    1 
ATOM 2623 C C     . GLY D 2 276 ? 176.512 241.141 205.433 1.00 73.70  ? 288 GLY A C     1 
ATOM 2624 O O     . GLY D 2 276 ? 176.889 241.581 204.341 1.00 73.70  ? 288 GLY A O     1 
ATOM 2625 N N     . TYR D 2 277 ? 177.245 241.243 206.538 1.00 74.88  ? 289 TYR A N     1 
ATOM 2626 C CA    . TYR D 2 277 ? 178.563 241.862 206.510 1.00 74.88  ? 289 TYR A CA    1 
ATOM 2627 C C     . TYR D 2 277 ? 179.527 240.999 205.708 1.00 74.88  ? 289 TYR A C     1 
ATOM 2628 O O     . TYR D 2 277 ? 179.622 239.787 205.925 1.00 74.88  ? 289 TYR A O     1 
ATOM 2629 C CB    . TYR D 2 277 ? 179.081 242.059 207.935 1.00 74.88  ? 289 TYR A CB    1 
ATOM 2630 C CG    . TYR D 2 277 ? 180.072 243.192 208.095 1.00 74.88  ? 289 TYR A CG    1 
ATOM 2631 C CD1   . TYR D 2 277 ? 181.267 243.203 207.390 1.00 74.88  ? 289 TYR A CD1   1 
ATOM 2632 C CD2   . TYR D 2 277 ? 179.813 244.247 208.959 1.00 74.88  ? 289 TYR A CD2   1 
ATOM 2633 C CE1   . TYR D 2 277 ? 182.174 244.233 207.538 1.00 74.88  ? 289 TYR A CE1   1 
ATOM 2634 C CE2   . TYR D 2 277 ? 180.715 245.282 209.112 1.00 74.88  ? 289 TYR A CE2   1 
ATOM 2635 C CZ    . TYR D 2 277 ? 181.894 245.269 208.399 1.00 74.88  ? 289 TYR A CZ    1 
ATOM 2636 O OH    . TYR D 2 277 ? 182.796 246.296 208.547 1.00 74.88  ? 289 TYR A OH    1 
ATOM 2637 N N     . ASP D 2 278 ? 180.242 241.625 204.780 1.00 77.54  ? 290 ASP A N     1 
ATOM 2638 C CA    . ASP D 2 278 ? 181.236 240.948 203.951 1.00 77.54  ? 290 ASP A CA    1 
ATOM 2639 C C     . ASP D 2 278 ? 182.604 241.503 204.328 1.00 77.54  ? 290 ASP A C     1 
ATOM 2640 O O     . ASP D 2 278 ? 182.925 242.655 204.021 1.00 77.54  ? 290 ASP A O     1 
ATOM 2641 C CB    . ASP D 2 278 ? 180.939 241.144 202.468 1.00 77.54  ? 290 ASP A CB    1 
ATOM 2642 C CG    . ASP D 2 278 ? 182.164 240.948 201.600 1.00 77.54  ? 290 ASP A CG    1 
ATOM 2643 O OD1   . ASP D 2 278 ? 182.582 239.786 201.416 1.00 77.54  ? 290 ASP A OD1   1 
ATOM 2644 O OD2   . ASP D 2 278 ? 182.710 241.955 201.105 1.00 77.54  ? 290 ASP A OD2   1 
ATOM 2645 N N     . PHE D 2 279 ? 183.409 240.680 205.000 1.00 73.48  ? 291 PHE A N     1 
ATOM 2646 C CA    . PHE D 2 279 ? 184.725 241.115 205.445 1.00 73.48  ? 291 PHE A CA    1 
ATOM 2647 C C     . PHE D 2 279 ? 185.760 241.107 204.329 1.00 73.48  ? 291 PHE A C     1 
ATOM 2648 O O     . PHE D 2 279 ? 186.859 241.635 204.527 1.00 73.48  ? 291 PHE A O     1 
ATOM 2649 C CB    . PHE D 2 279 ? 185.198 240.232 206.599 1.00 73.48  ? 291 PHE A CB    1 
ATOM 2650 C CG    . PHE D 2 279 ? 184.341 240.330 207.826 1.00 73.48  ? 291 PHE A CG    1 
ATOM 2651 C CD1   . PHE D 2 279 ? 184.487 241.389 208.705 1.00 73.48  ? 291 PHE A CD1   1 
ATOM 2652 C CD2   . PHE D 2 279 ? 183.386 239.367 208.098 1.00 73.48  ? 291 PHE A CD2   1 
ATOM 2653 C CE1   . PHE D 2 279 ? 183.700 241.482 209.834 1.00 73.48  ? 291 PHE A CE1   1 
ATOM 2654 C CE2   . PHE D 2 279 ? 182.596 239.454 209.225 1.00 73.48  ? 291 PHE A CE2   1 
ATOM 2655 C CZ    . PHE D 2 279 ? 182.753 240.513 210.094 1.00 73.48  ? 291 PHE A CZ    1 
ATOM 2656 N N     . GLU D 2 280 ? 185.443 240.519 203.174 1.00 77.97  ? 292 GLU A N     1 
ATOM 2657 C CA    . GLU D 2 280 ? 186.389 240.512 202.063 1.00 77.97  ? 292 GLU A CA    1 
ATOM 2658 C C     . GLU D 2 280 ? 186.640 241.920 201.539 1.00 77.97  ? 292 GLU A C     1 
ATOM 2659 O O     . GLU D 2 280 ? 187.786 242.295 201.267 1.00 77.97  ? 292 GLU A O     1 
ATOM 2660 C CB    . GLU D 2 280 ? 185.873 239.609 200.943 1.00 77.97  ? 292 GLU A CB    1 
ATOM 2661 C CG    . GLU D 2 280 ? 185.854 238.133 201.296 1.00 77.97  ? 292 GLU A CG    1 
ATOM 2662 C CD    . GLU D 2 280 ? 186.938 237.355 200.584 1.00 77.97  ? 292 GLU A CD    1 
ATOM 2663 O OE1   . GLU D 2 280 ? 188.015 237.933 200.331 1.00 77.97  ? 292 GLU A OE1   1 
ATOM 2664 O OE2   . GLU D 2 280 ? 186.714 236.166 200.277 1.00 77.97  ? 292 GLU A OE2   1 
ATOM 2665 N N     . ARG D 2 281 ? 185.580 242.717 201.391 1.00 78.31  ? 293 ARG A N     1 
ATOM 2666 C CA    . ARG D 2 281 ? 185.734 244.067 200.862 1.00 78.31  ? 293 ARG A CA    1 
ATOM 2667 C C     . ARG D 2 281 ? 186.079 245.059 201.966 1.00 78.31  ? 293 ARG A C     1 
ATOM 2668 O O     . ARG D 2 281 ? 186.988 245.882 201.810 1.00 78.31  ? 293 ARG A O     1 
ATOM 2669 C CB    . ARG D 2 281 ? 184.459 244.495 200.134 1.00 78.31  ? 293 ARG A CB    1 
ATOM 2670 C CG    . ARG D 2 281 ? 184.183 243.728 198.848 1.00 78.31  ? 293 ARG A CG    1 
ATOM 2671 C CD    . ARG D 2 281 ? 182.915 244.220 198.162 1.00 78.31  ? 293 ARG A CD    1 
ATOM 2672 N NE    . ARG D 2 281 ? 181.722 243.961 198.959 1.00 78.31  ? 293 ARG A NE    1 
ATOM 2673 C CZ    . ARG D 2 281 ? 181.079 244.878 199.670 1.00 78.31  ? 293 ARG A CZ    1 
ATOM 2674 N NH1   . ARG D 2 281 ? 181.488 246.136 199.704 1.00 78.31  ? 293 ARG A NH1   1 
ATOM 2675 N NH2   . ARG D 2 281 ? 179.999 244.526 200.361 1.00 78.31  ? 293 ARG A NH2   1 
ATOM 2676 N N     . GLU D 2 282 ? 185.362 244.997 203.090 1.00 75.96  ? 294 GLU A N     1 
ATOM 2677 C CA    . GLU D 2 282 ? 185.601 245.935 204.180 1.00 75.96  ? 294 GLU A CA    1 
ATOM 2678 C C     . GLU D 2 282 ? 186.922 245.679 204.892 1.00 75.96  ? 294 GLU A C     1 
ATOM 2679 O O     . GLU D 2 282 ? 187.464 246.598 205.514 1.00 75.96  ? 294 GLU A O     1 
ATOM 2680 C CB    . GLU D 2 282 ? 184.451 245.874 205.185 1.00 75.96  ? 294 GLU A CB    1 
ATOM 2681 C CG    . GLU D 2 282 ? 183.070 245.875 204.551 1.00 75.96  ? 294 GLU A CG    1 
ATOM 2682 C CD    . GLU D 2 282 ? 182.571 247.270 204.240 1.00 75.96  ? 294 GLU A CD    1 
ATOM 2683 O OE1   . GLU D 2 282 ? 183.142 247.923 203.341 1.00 75.96  ? 294 GLU A OE1   1 
ATOM 2684 O OE2   . GLU D 2 282 ? 181.606 247.716 204.895 1.00 75.96  ? 294 GLU A OE2   1 
ATOM 2685 N N     . GLY D 2 283 ? 187.451 244.462 204.815 1.00 75.20  ? 295 GLY A N     1 
ATOM 2686 C CA    . GLY D 2 283 ? 188.689 244.137 205.489 1.00 75.20  ? 295 GLY A CA    1 
ATOM 2687 C C     . GLY D 2 283 ? 188.480 243.829 206.958 1.00 75.20  ? 295 GLY A C     1 
ATOM 2688 O O     . GLY D 2 283 ? 187.376 243.892 207.500 1.00 75.20  ? 295 GLY A O     1 
ATOM 2689 N N     . TYR D 2 284 ? 189.584 243.488 207.615 1.00 72.90  ? 296 TYR A N     1 
ATOM 2690 C CA    . TYR D 2 284 ? 189.561 243.145 209.030 1.00 72.90  ? 296 TYR A CA    1 
ATOM 2691 C C     . TYR D 2 284 ? 190.954 243.362 209.600 1.00 72.90  ? 296 TYR A C     1 
ATOM 2692 O O     . TYR D 2 284 ? 191.932 243.509 208.864 1.00 72.90  ? 296 TYR A O     1 
ATOM 2693 C CB    . TYR D 2 284 ? 189.092 241.703 209.248 1.00 72.90  ? 296 TYR A CB    1 
ATOM 2694 C CG    . TYR D 2 284 ? 188.496 241.449 210.613 1.00 72.90  ? 296 TYR A CG    1 
ATOM 2695 C CD1   . TYR D 2 284 ? 187.275 242.000 210.973 1.00 72.90  ? 296 TYR A CD1   1 
ATOM 2696 C CD2   . TYR D 2 284 ? 189.156 240.655 211.541 1.00 72.90  ? 296 TYR A CD2   1 
ATOM 2697 C CE1   . TYR D 2 284 ? 186.729 241.769 212.219 1.00 72.90  ? 296 TYR A CE1   1 
ATOM 2698 C CE2   . TYR D 2 284 ? 188.618 240.419 212.790 1.00 72.90  ? 296 TYR A CE2   1 
ATOM 2699 C CZ    . TYR D 2 284 ? 187.405 240.978 213.124 1.00 72.90  ? 296 TYR A CZ    1 
ATOM 2700 O OH    . TYR D 2 284 ? 186.865 240.744 214.367 1.00 72.90  ? 296 TYR A OH    1 
ATOM 2701 N N     . SER D 2 285 ? 191.030 243.390 210.927 1.00 69.69  ? 297 SER A N     1 
ATOM 2702 C CA    . SER D 2 285 ? 192.310 243.539 211.614 1.00 69.69  ? 297 SER A CA    1 
ATOM 2703 C C     . SER D 2 285 ? 192.150 243.018 213.030 1.00 69.69  ? 297 SER A C     1 
ATOM 2704 O O     . SER D 2 285 ? 191.312 243.525 213.782 1.00 69.69  ? 297 SER A O     1 
ATOM 2705 C CB    . SER D 2 285 ? 192.766 244.997 211.619 1.00 69.69  ? 297 SER A CB    1 
ATOM 2706 O OG    . SER D 2 285 ? 193.984 245.144 212.328 1.00 69.69  ? 297 SER A OG    1 
ATOM 2707 N N     . LEU D 2 286 ? 192.948 242.014 213.396 1.00 69.68  ? 298 LEU A N     1 
ATOM 2708 C CA    . LEU D 2 286 ? 192.850 241.422 214.724 1.00 69.68  ? 298 LEU A CA    1 
ATOM 2709 C C     . LEU D 2 286 ? 193.310 242.364 215.828 1.00 69.68  ? 298 LEU A C     1 
ATOM 2710 O O     . LEU D 2 286 ? 193.012 242.107 216.998 1.00 69.68  ? 298 LEU A O     1 
ATOM 2711 C CB    . LEU D 2 286 ? 193.660 240.127 214.779 1.00 69.68  ? 298 LEU A CB    1 
ATOM 2712 C CG    . LEU D 2 286 ? 193.262 239.056 213.763 1.00 69.68  ? 298 LEU A CG    1 
ATOM 2713 C CD1   . LEU D 2 286 ? 194.062 237.782 213.983 1.00 69.68  ? 298 LEU A CD1   1 
ATOM 2714 C CD2   . LEU D 2 286 ? 191.770 238.778 213.839 1.00 69.68  ? 298 LEU A CD2   1 
ATOM 2715 N N     . VAL D 2 287 ? 194.021 243.439 215.491 1.00 70.08  ? 299 VAL A N     1 
ATOM 2716 C CA    . VAL D 2 287 ? 194.487 244.413 216.468 1.00 70.08  ? 299 VAL A CA    1 
ATOM 2717 C C     . VAL D 2 287 ? 193.815 245.767 216.311 1.00 70.08  ? 299 VAL A C     1 
ATOM 2718 O O     . VAL D 2 287 ? 194.075 246.669 217.113 1.00 70.08  ? 299 VAL A O     1 
ATOM 2719 C CB    . VAL D 2 287 ? 196.020 244.573 216.415 1.00 70.08  ? 299 VAL A CB    1 
ATOM 2720 C CG1   . VAL D 2 287 ? 196.703 243.310 216.910 1.00 70.08  ? 299 VAL A CG1   1 
ATOM 2721 C CG2   . VAL D 2 287 ? 196.467 244.910 215.003 1.00 70.08  ? 299 VAL A CG2   1 
ATOM 2722 N N     . GLY D 2 288 ? 192.960 245.939 215.310 1.00 70.30  ? 300 GLY A N     1 
ATOM 2723 C CA    . GLY D 2 288 ? 192.314 247.206 215.047 1.00 70.30  ? 300 GLY A CA    1 
ATOM 2724 C C     . GLY D 2 288 ? 190.994 247.358 215.771 1.00 70.30  ? 300 GLY A C     1 
ATOM 2725 O O     . GLY D 2 288 ? 190.695 246.656 216.740 1.00 70.30  ? 300 GLY A O     1 
ATOM 2726 N N     . ILE D 2 289 ? 190.190 248.304 215.284 1.00 76.15  ? 301 ILE A N     1 
ATOM 2727 C CA    . ILE D 2 289 ? 188.896 248.574 215.899 1.00 76.15  ? 301 ILE A CA    1 
ATOM 2728 C C     . ILE D 2 289 ? 187.866 247.521 215.504 1.00 76.15  ? 301 ILE A C     1 
ATOM 2729 O O     . ILE D 2 289 ? 186.875 247.327 216.217 1.00 76.15  ? 301 ILE A O     1 
ATOM 2730 C CB    . ILE D 2 289 ? 188.419 249.989 215.526 1.00 76.15  ? 301 ILE A CB    1 
ATOM 2731 C CG1   . ILE D 2 289 ? 187.137 250.349 216.281 1.00 76.15  ? 301 ILE A CG1   1 
ATOM 2732 C CG2   . ILE D 2 289 ? 188.203 250.103 214.026 1.00 76.15  ? 301 ILE A CG2   1 
ATOM 2733 C CD1   . ILE D 2 289 ? 186.733 251.798 216.150 1.00 76.15  ? 301 ILE A CD1   1 
ATOM 2734 N N     . ASP D 2 290 ? 188.090 246.814 214.397 1.00 73.64  ? 302 ASP A N     1 
ATOM 2735 C CA    . ASP D 2 290 ? 187.077 245.919 213.836 1.00 73.64  ? 302 ASP A CA    1 
ATOM 2736 C C     . ASP D 2 290 ? 186.531 244.894 214.823 1.00 73.64  ? 302 ASP A C     1 
ATOM 2737 O O     . ASP D 2 290 ? 185.301 244.739 214.888 1.00 73.64  ? 302 ASP A O     1 
ATOM 2738 C CB    . ASP D 2 290 ? 187.647 245.228 212.590 1.00 73.64  ? 302 ASP A CB    1 
ATOM 2739 C CG    . ASP D 2 290 ? 187.984 246.206 211.485 1.00 73.64  ? 302 ASP A CG    1 
ATOM 2740 O OD1   . ASP D 2 290 ? 188.973 246.954 211.633 1.00 73.64  ? 302 ASP A OD1   1 
ATOM 2741 O OD2   . ASP D 2 290 ? 187.258 246.230 210.470 1.00 73.64  ? 302 ASP A OD2   1 
ATOM 2742 N N     . PRO D 2 291 ? 187.345 244.162 215.595 1.00 70.67  ? 303 PRO A N     1 
ATOM 2743 C CA    . PRO D 2 291 ? 186.744 243.231 216.567 1.00 70.67  ? 303 PRO A CA    1 
ATOM 2744 C C     . PRO D 2 291 ? 185.945 243.932 217.650 1.00 70.67  ? 303 PRO A C     1 
ATOM 2745 O O     . PRO D 2 291 ? 184.896 243.423 218.066 1.00 70.67  ? 303 PRO A O     1 
ATOM 2746 C CB    . PRO D 2 291 ? 187.957 242.484 217.142 1.00 70.67  ? 303 PRO A CB    1 
ATOM 2747 C CG    . PRO D 2 291 ? 189.065 242.728 216.174 1.00 70.67  ? 303 PRO A CG    1 
ATOM 2748 C CD    . PRO D 2 291 ? 188.815 244.090 215.625 1.00 70.67  ? 303 PRO A CD    1 
ATOM 2749 N N     . PHE D 2 292 ? 186.409 245.094 218.115 1.00 72.25  ? 304 PHE A N     1 
ATOM 2750 C CA    . PHE D 2 292 ? 185.663 245.839 219.124 1.00 72.25  ? 304 PHE A CA    1 
ATOM 2751 C C     . PHE D 2 292 ? 184.309 246.285 218.588 1.00 72.25  ? 304 PHE A C     1 
ATOM 2752 O O     . PHE D 2 292 ? 183.289 246.162 219.275 1.00 72.25  ? 304 PHE A O     1 
ATOM 2753 C CB    . PHE D 2 292 ? 186.477 247.047 219.587 1.00 72.25  ? 304 PHE A CB    1 
ATOM 2754 C CG    . PHE D 2 292 ? 187.273 246.800 220.835 1.00 72.25  ? 304 PHE A CG    1 
ATOM 2755 C CD1   . PHE D 2 292 ? 186.642 246.644 222.056 1.00 72.25  ? 304 PHE A CD1   1 
ATOM 2756 C CD2   . PHE D 2 292 ? 188.654 246.728 220.788 1.00 72.25  ? 304 PHE A CD2   1 
ATOM 2757 C CE1   . PHE D 2 292 ? 187.373 246.422 223.205 1.00 72.25  ? 304 PHE A CE1   1 
ATOM 2758 C CE2   . PHE D 2 292 ? 189.388 246.504 221.933 1.00 72.25  ? 304 PHE A CE2   1 
ATOM 2759 C CZ    . PHE D 2 292 ? 188.748 246.350 223.143 1.00 72.25  ? 304 PHE A CZ    1 
ATOM 2760 N N     . ARG D 2 293 ? 184.282 246.804 217.360 1.00 71.72  ? 305 ARG A N     1 
ATOM 2761 C CA    . ARG D 2 293 ? 183.024 247.219 216.751 1.00 71.72  ? 305 ARG A CA    1 
ATOM 2762 C C     . ARG D 2 293 ? 182.112 246.025 216.506 1.00 71.72  ? 305 ARG A C     1 
ATOM 2763 O O     . ARG D 2 293 ? 180.892 246.119 216.686 1.00 71.72  ? 305 ARG A O     1 
ATOM 2764 C CB    . ARG D 2 293 ? 183.300 247.969 215.448 1.00 71.72  ? 305 ARG A CB    1 
ATOM 2765 C CG    . ARG D 2 293 ? 182.127 248.031 214.491 1.00 71.72  ? 305 ARG A CG    1 
ATOM 2766 C CD    . ARG D 2 293 ? 182.458 248.902 213.296 1.00 71.72  ? 305 ARG A CD    1 
ATOM 2767 N NE    . ARG D 2 293 ? 183.419 248.255 212.412 1.00 71.72  ? 305 ARG A NE    1 
ATOM 2768 C CZ    . ARG D 2 293 ? 184.373 248.892 211.749 1.00 71.72  ? 305 ARG A CZ    1 
ATOM 2769 N NH1   . ARG D 2 293 ? 184.526 250.203 211.848 1.00 71.72  ? 305 ARG A NH1   1 
ATOM 2770 N NH2   . ARG D 2 293 ? 185.196 248.198 210.968 1.00 71.72  ? 305 ARG A NH2   1 
ATOM 2771 N N     . LEU D 2 294 ? 182.686 244.891 216.097 1.00 71.02  ? 306 LEU A N     1 
ATOM 2772 C CA    . LEU D 2 294 ? 181.890 243.689 215.886 1.00 71.02  ? 306 LEU A CA    1 
ATOM 2773 C C     . LEU D 2 294 ? 181.243 243.226 217.184 1.00 71.02  ? 306 LEU A C     1 
ATOM 2774 O O     . LEU D 2 294 ? 180.064 242.855 217.202 1.00 71.02  ? 306 LEU A O     1 
ATOM 2775 C CB    . LEU D 2 294 ? 182.767 242.586 215.297 1.00 71.02  ? 306 LEU A CB    1 
ATOM 2776 C CG    . LEU D 2 294 ? 182.028 241.399 214.688 1.00 71.02  ? 306 LEU A CG    1 
ATOM 2777 C CD1   . LEU D 2 294 ? 181.156 241.881 213.546 1.00 71.02  ? 306 LEU A CD1   1 
ATOM 2778 C CD2   . LEU D 2 294 ? 183.010 240.344 214.212 1.00 71.02  ? 306 LEU A CD2   1 
ATOM 2779 N N     . LEU D 2 295 ? 181.998 243.249 218.285 1.00 72.02  ? 307 LEU A N     1 
ATOM 2780 C CA    . LEU D 2 295 ? 181.429 242.901 219.582 1.00 72.02  ? 307 LEU A CA    1 
ATOM 2781 C C     . LEU D 2 295 ? 180.431 243.950 220.058 1.00 72.02  ? 307 LEU A C     1 
ATOM 2782 O O     . LEU D 2 295 ? 179.523 243.633 220.833 1.00 72.02  ? 307 LEU A O     1 
ATOM 2783 C CB    . LEU D 2 295 ? 182.544 242.726 220.612 1.00 72.02  ? 307 LEU A CB    1 
ATOM 2784 C CG    . LEU D 2 295 ? 183.115 241.316 220.768 1.00 72.02  ? 307 LEU A CG    1 
ATOM 2785 C CD1   . LEU D 2 295 ? 183.940 241.212 222.040 1.00 72.02  ? 307 LEU A CD1   1 
ATOM 2786 C CD2   . LEU D 2 295 ? 182.002 240.281 220.763 1.00 72.02  ? 307 LEU A CD2   1 
ATOM 2787 N N     . GLN D 2 296 ? 180.590 245.198 219.612 1.00 75.28  ? 308 GLN A N     1 
ATOM 2788 C CA    . GLN D 2 296 ? 179.690 246.267 220.034 1.00 75.28  ? 308 GLN A CA    1 
ATOM 2789 C C     . GLN D 2 296 ? 178.262 246.012 219.570 1.00 75.28  ? 308 GLN A C     1 
ATOM 2790 O O     . GLN D 2 296 ? 177.307 246.241 220.320 1.00 75.28  ? 308 GLN A O     1 
ATOM 2791 C CB    . GLN D 2 296 ? 180.195 247.609 219.500 1.00 75.28  ? 308 GLN A CB    1 
ATOM 2792 C CG    . GLN D 2 296 ? 180.992 248.441 220.497 1.00 75.28  ? 308 GLN A CG    1 
ATOM 2793 C CD    . GLN D 2 296 ? 180.136 249.041 221.599 1.00 75.28  ? 308 GLN A CD    1 
ATOM 2794 O OE1   . GLN D 2 296 ? 178.951 248.738 221.723 1.00 75.28  ? 308 GLN A OE1   1 
ATOM 2795 N NE2   . GLN D 2 296 ? 180.742 249.902 222.409 1.00 75.28  ? 308 GLN A NE2   1 
ATOM 2796 N N     . ASN D 2 297 ? 178.096 245.538 218.336 1.00 76.76  ? 309 ASN A N     1 
ATOM 2797 C CA    . ASN D 2 297 ? 176.782 245.318 217.747 1.00 76.76  ? 309 ASN A CA    1 
ATOM 2798 C C     . ASN D 2 297 ? 176.477 243.835 217.546 1.00 76.76  ? 309 ASN A C     1 
ATOM 2799 O O     . ASN D 2 297 ? 175.854 243.453 216.553 1.00 76.76  ? 309 ASN A O     1 
ATOM 2800 C CB    . ASN D 2 297 ? 176.661 246.081 216.428 1.00 76.76  ? 309 ASN A CB    1 
ATOM 2801 C CG    . ASN D 2 297 ? 177.818 245.809 215.483 1.00 76.76  ? 309 ASN A CG    1 
ATOM 2802 O OD1   . ASN D 2 297 ? 178.354 244.703 215.434 1.00 76.76  ? 309 ASN A OD1   1 
ATOM 2803 N ND2   . ASN D 2 297 ? 178.209 246.827 214.726 1.00 76.76  ? 309 ASN A ND2   1 
ATOM 2804 N N     . SER D 2 298 ? 176.910 242.989 218.478 1.00 70.52  ? 310 SER A N     1 
ATOM 2805 C CA    . SER D 2 298 ? 176.629 241.562 218.433 1.00 70.52  ? 310 SER A CA    1 
ATOM 2806 C C     . SER D 2 298 ? 176.094 241.106 219.782 1.00 70.52  ? 310 SER A C     1 
ATOM 2807 O O     . SER D 2 298 ? 176.503 241.620 220.827 1.00 70.52  ? 310 SER A O     1 
ATOM 2808 C CB    . SER D 2 298 ? 177.878 240.754 218.067 1.00 70.52  ? 310 SER A CB    1 
ATOM 2809 O OG    . SER D 2 298 ? 178.760 240.656 219.171 1.00 70.52  ? 310 SER A OG    1 
ATOM 2810 N N     . GLN D 2 299 ? 175.181 240.140 219.752 1.00 69.34  ? 311 GLN A N     1 
ATOM 2811 C CA    . GLN D 2 299 ? 174.575 239.587 220.955 1.00 69.34  ? 311 GLN A CA    1 
ATOM 2812 C C     . GLN D 2 299 ? 174.918 238.107 221.065 1.00 69.34  ? 311 GLN A C     1 
ATOM 2813 O O     . GLN D 2 299 ? 174.782 237.357 220.093 1.00 69.34  ? 311 GLN A O     1 
ATOM 2814 C CB    . GLN D 2 299 ? 173.058 239.793 220.948 1.00 69.34  ? 311 GLN A CB    1 
ATOM 2815 C CG    . GLN D 2 299 ? 172.346 239.217 219.736 1.00 69.34  ? 311 GLN A CG    1 
ATOM 2816 C CD    . GLN D 2 299 ? 170.851 239.445 219.777 1.00 69.34  ? 311 GLN A CD    1 
ATOM 2817 O OE1   . GLN D 2 299 ? 170.365 240.320 220.493 1.00 69.34  ? 311 GLN A OE1   1 
ATOM 2818 N NE2   . GLN D 2 299 ? 170.111 238.658 219.005 1.00 69.34  ? 311 GLN A NE2   1 
ATOM 2819 N N     . VAL D 2 300 ? 175.379 237.697 222.243 1.00 71.32  ? 312 VAL A N     1 
ATOM 2820 C CA    . VAL D 2 300 ? 175.758 236.315 222.511 1.00 71.32  ? 312 VAL A CA    1 
ATOM 2821 C C     . VAL D 2 300 ? 175.117 235.891 223.824 1.00 71.32  ? 312 VAL A C     1 
ATOM 2822 O O     . VAL D 2 300 ? 175.182 236.624 224.816 1.00 71.32  ? 312 VAL A O     1 
ATOM 2823 C CB    . VAL D 2 300 ? 177.288 236.142 222.570 1.00 71.32  ? 312 VAL A CB    1 
ATOM 2824 C CG1   . VAL D 2 300 ? 177.653 234.761 223.092 1.00 71.32  ? 312 VAL A CG1   1 
ATOM 2825 C CG2   . VAL D 2 300 ? 177.903 236.374 221.199 1.00 71.32  ? 312 VAL A CG2   1 
ATOM 2826 N N     . TYR D 2 301 ? 174.496 234.715 223.828 1.00 74.49  ? 313 TYR A N     1 
ATOM 2827 C CA    . TYR D 2 301 ? 173.872 234.158 225.016 1.00 74.49  ? 313 TYR A CA    1 
ATOM 2828 C C     . TYR D 2 301 ? 174.698 232.991 225.541 1.00 74.49  ? 313 TYR A C     1 
ATOM 2829 O O     . TYR D 2 301 ? 175.323 232.256 224.772 1.00 74.49  ? 313 TYR A O     1 
ATOM 2830 C CB    . TYR D 2 301 ? 172.443 233.697 224.721 1.00 74.49  ? 313 TYR A CB    1 
ATOM 2831 C CG    . TYR D 2 301 ? 171.579 234.764 224.092 1.00 74.49  ? 313 TYR A CG    1 
ATOM 2832 C CD1   . TYR D 2 301 ? 171.020 235.774 224.863 1.00 74.49  ? 313 TYR A CD1   1 
ATOM 2833 C CD2   . TYR D 2 301 ? 171.323 234.763 222.729 1.00 74.49  ? 313 TYR A CD2   1 
ATOM 2834 C CE1   . TYR D 2 301 ? 170.229 236.752 224.293 1.00 74.49  ? 313 TYR A CE1   1 
ATOM 2835 C CE2   . TYR D 2 301 ? 170.533 235.736 222.150 1.00 74.49  ? 313 TYR A CE2   1 
ATOM 2836 C CZ    . TYR D 2 301 ? 169.989 236.728 222.937 1.00 74.49  ? 313 TYR A CZ    1 
ATOM 2837 O OH    . TYR D 2 301 ? 169.202 237.700 222.366 1.00 74.49  ? 313 TYR A OH    1 
ATOM 2838 N N     . SER D 2 302 ? 174.700 232.830 226.862 1.00 73.21  ? 314 SER A N     1 
ATOM 2839 C CA    . SER D 2 302 ? 175.491 231.795 227.508 1.00 73.21  ? 314 SER A CA    1 
ATOM 2840 C C     . SER D 2 302 ? 174.669 231.121 228.596 1.00 73.21  ? 314 SER A C     1 
ATOM 2841 O O     . SER D 2 302 ? 173.755 231.721 229.169 1.00 73.21  ? 314 SER A O     1 
ATOM 2842 C CB    . SER D 2 302 ? 176.780 232.367 228.111 1.00 73.21  ? 314 SER A CB    1 
ATOM 2843 O OG    . SER D 2 302 ? 177.330 231.481 229.070 1.00 73.21  ? 314 SER A OG    1 
ATOM 2844 N N     . LEU D 2 303 ? 175.006 229.865 228.874 1.00 77.32  ? 315 LEU A N     1 
ATOM 2845 C CA    . LEU D 2 303 ? 174.377 229.130 229.963 1.00 77.32  ? 315 LEU A CA    1 
ATOM 2846 C C     . LEU D 2 303 ? 174.956 229.589 231.294 1.00 77.32  ? 315 LEU A C     1 
ATOM 2847 O O     . LEU D 2 303 ? 176.176 229.713 231.441 1.00 77.32  ? 315 LEU A O     1 
ATOM 2848 C CB    . LEU D 2 303 ? 174.585 227.627 229.784 1.00 77.32  ? 315 LEU A CB    1 
ATOM 2849 C CG    . LEU D 2 303 ? 173.917 227.000 228.561 1.00 77.32  ? 315 LEU A CG    1 
ATOM 2850 C CD1   . LEU D 2 303 ? 174.150 225.499 228.539 1.00 77.32  ? 315 LEU A CD1   1 
ATOM 2851 C CD2   . LEU D 2 303 ? 172.431 227.316 228.544 1.00 77.32  ? 315 LEU A CD2   1 
ATOM 2852 N N     . ILE D 2 304 ? 174.081 229.839 232.263 1.00 74.89  ? 316 ILE A N     1 
ATOM 2853 C CA    . ILE D 2 304 ? 174.472 230.342 233.574 1.00 74.89  ? 316 ILE A CA    1 
ATOM 2854 C C     . ILE D 2 304 ? 174.138 229.273 234.606 1.00 74.89  ? 316 ILE A C     1 
ATOM 2855 O O     . ILE D 2 304 ? 172.986 228.830 234.702 1.00 74.89  ? 316 ILE A O     1 
ATOM 2856 C CB    . ILE D 2 304 ? 173.774 231.672 233.898 1.00 74.89  ? 316 ILE A CB    1 
ATOM 2857 C CG1   . ILE D 2 304 ? 174.522 232.838 233.251 1.00 74.89  ? 316 ILE A CG1   1 
ATOM 2858 C CG2   . ILE D 2 304 ? 173.687 231.890 235.397 1.00 74.89  ? 316 ILE A CG2   1 
ATOM 2859 C CD1   . ILE D 2 304 ? 175.852 233.138 233.898 1.00 74.89  ? 316 ILE A CD1   1 
ATOM 2860 N N     . ARG D 2 305 ? 175.145 228.853 235.367 1.00 72.44  ? 317 ARG A N     1 
ATOM 2861 C CA    . ARG D 2 305 ? 174.934 227.895 236.436 1.00 72.44  ? 317 ARG A CA    1 
ATOM 2862 C C     . ARG D 2 305 ? 174.167 228.549 237.583 1.00 72.44  ? 317 ARG A C     1 
ATOM 2863 O O     . ARG D 2 305 ? 174.123 229.777 237.690 1.00 72.44  ? 317 ARG A O     1 
ATOM 2864 C CB    . ARG D 2 305 ? 176.271 227.357 236.942 1.00 72.44  ? 317 ARG A CB    1 
ATOM 2865 C CG    . ARG D 2 305 ? 177.273 227.020 235.856 1.00 72.44  ? 317 ARG A CG    1 
ATOM 2866 C CD    . ARG D 2 305 ? 178.250 225.963 236.342 1.00 72.44  ? 317 ARG A CD    1 
ATOM 2867 N NE    . ARG D 2 305 ? 179.575 226.128 235.760 1.00 72.44  ? 317 ARG A NE    1 
ATOM 2868 C CZ    . ARG D 2 305 ? 180.296 225.139 235.250 1.00 72.44  ? 317 ARG A CZ    1 
ATOM 2869 N NH1   . ARG D 2 305 ? 179.850 223.894 235.237 1.00 72.44  ? 317 ARG A NH1   1 
ATOM 2870 N NH2   . ARG D 2 305 ? 181.496 225.405 234.742 1.00 72.44  ? 317 ARG A NH2   1 
ATOM 2871 N N     . PRO D 2 306 ? 173.545 227.750 238.452 1.00 75.02  ? 318 PRO A N     1 
ATOM 2872 C CA    . PRO D 2 306 ? 172.887 228.324 239.631 1.00 75.02  ? 318 PRO A CA    1 
ATOM 2873 C C     . PRO D 2 306 ? 173.866 229.128 240.474 1.00 75.02  ? 318 PRO A C     1 
ATOM 2874 O O     . PRO D 2 306 ? 175.085 228.980 240.352 1.00 75.02  ? 318 PRO A O     1 
ATOM 2875 C CB    . PRO D 2 306 ? 172.368 227.094 240.389 1.00 75.02  ? 318 PRO A CB    1 
ATOM 2876 C CG    . PRO D 2 306 ? 173.068 225.917 239.773 1.00 75.02  ? 318 PRO A CG    1 
ATOM 2877 C CD    . PRO D 2 306 ? 173.316 226.300 238.354 1.00 75.02  ? 318 PRO A CD    1 
ATOM 2878 N N     . ASN D 2 307 ? 173.302 230.018 241.292 1.00 81.14  ? 319 ASN A N     1 
ATOM 2879 C CA    . ASN D 2 307 ? 174.008 230.971 242.164 1.00 81.14  ? 319 ASN A CA    1 
ATOM 2880 C C     . ASN D 2 307 ? 175.339 231.415 241.555 1.00 81.14  ? 319 ASN A C     1 
ATOM 2881 O O     . ASN D 2 307 ? 176.414 231.263 242.136 1.00 81.14  ? 319 ASN A O     1 
ATOM 2882 C CB    . ASN D 2 307 ? 174.176 230.469 243.613 1.00 81.14  ? 319 ASN A CB    1 
ATOM 2883 C CG    . ASN D 2 307 ? 172.886 230.428 244.437 1.00 81.14  ? 319 ASN A CG    1 
ATOM 2884 O OD1   . ASN D 2 307 ? 171.912 231.113 244.173 1.00 81.14  ? 319 ASN A OD1   1 
ATOM 2885 N ND2   . ASN D 2 307 ? 172.900 229.591 245.467 1.00 81.14  ? 319 ASN A ND2   1 
ATOM 2886 N N     . GLU D 2 308 ? 175.240 231.972 240.349 1.00 76.13  ? 320 GLU A N     1 
ATOM 2887 C CA    . GLU D 2 308 ? 176.384 232.512 239.632 1.00 76.13  ? 320 GLU A CA    1 
ATOM 2888 C C     . GLU D 2 308 ? 176.009 233.866 239.047 1.00 76.13  ? 320 GLU A C     1 
ATOM 2889 O O     . GLU D 2 308 ? 174.845 234.118 238.725 1.00 76.13  ? 320 GLU A O     1 
ATOM 2890 C CB    . GLU D 2 308 ? 176.855 231.565 238.521 1.00 76.13  ? 320 GLU A CB    1 
ATOM 2891 C CG    . GLU D 2 308 ? 177.796 230.473 239.000 1.00 76.13  ? 320 GLU A CG    1 
ATOM 2892 C CD    . GLU D 2 308 ? 178.583 229.848 237.868 1.00 76.13  ? 320 GLU A CD    1 
ATOM 2893 O OE1   . GLU D 2 308 ? 178.331 230.205 236.699 1.00 76.13  ? 320 GLU A OE1   1 
ATOM 2894 O OE2   . GLU D 2 308 ? 179.454 228.997 238.146 1.00 76.13  ? 320 GLU A OE2   1 
ATOM 2895 N N     . ASN D 2 309 ? 177.009 234.736 238.911 1.00 76.35  ? 321 ASN A N     1 
ATOM 2896 C CA    . ASN D 2 309 ? 176.783 236.102 238.460 1.00 76.35  ? 321 ASN A CA    1 
ATOM 2897 C C     . ASN D 2 309 ? 176.973 236.191 236.956 1.00 76.35  ? 321 ASN A C     1 
ATOM 2898 O O     . ASN D 2 309 ? 178.070 235.886 236.462 1.00 76.35  ? 321 ASN A O     1 
ATOM 2899 C CB    . ASN D 2 309 ? 177.732 237.062 239.166 1.00 76.35  ? 321 ASN A CB    1 
ATOM 2900 C CG    . ASN D 2 309 ? 177.235 238.494 239.145 1.00 76.35  ? 321 ASN A CG    1 
ATOM 2901 O OD1   . ASN D 2 309 ? 176.151 238.781 238.639 1.00 76.35  ? 321 ASN A OD1   1 
ATOM 2902 N ND2   . ASN D 2 309 ? 178.030 239.403 239.698 1.00 76.35  ? 321 ASN A ND2   1 
ATOM 2903 N N     . PRO D 2 310 ? 175.951 236.587 236.193 1.00 76.56  ? 322 PRO A N     1 
ATOM 2904 C CA    . PRO D 2 310 ? 176.150 236.776 234.747 1.00 76.56  ? 322 PRO A CA    1 
ATOM 2905 C C     . PRO D 2 310 ? 177.183 237.837 234.412 1.00 76.56  ? 322 PRO A C     1 
ATOM 2906 O O     . PRO D 2 310 ? 177.868 237.719 233.389 1.00 76.56  ? 322 PRO A O     1 
ATOM 2907 C CB    . PRO D 2 310 ? 174.752 237.171 234.249 1.00 76.56  ? 322 PRO A CB    1 
ATOM 2908 C CG    . PRO D 2 310 ? 174.043 237.684 235.459 1.00 76.56  ? 322 PRO A CG    1 
ATOM 2909 C CD    . PRO D 2 310 ? 174.568 236.877 236.605 1.00 76.56  ? 322 PRO A CD    1 
ATOM 2910 N N     . ALA D 2 311 ? 177.308 238.878 235.240 1.00 73.13  ? 323 ALA A N     1 
ATOM 2911 C CA    . ALA D 2 311 ? 178.280 239.931 234.965 1.00 73.13  ? 323 ALA A CA    1 
ATOM 2912 C C     . ALA D 2 311 ? 179.706 239.396 235.003 1.00 73.13  ? 323 ALA A C     1 
ATOM 2913 O O     . ALA D 2 311 ? 180.533 239.750 234.154 1.00 73.13  ? 323 ALA A O     1 
ATOM 2914 C CB    . ALA D 2 311 ? 178.110 241.075 235.964 1.00 73.13  ? 323 ALA A CB    1 
ATOM 2915 N N     . HIS D 2 312 ? 180.016 238.545 235.983 1.00 70.36  ? 324 HIS A N     1 
ATOM 2916 C CA    . HIS D 2 312 ? 181.360 237.986 236.080 1.00 70.36  ? 324 HIS A CA    1 
ATOM 2917 C C     . HIS D 2 312 ? 181.676 237.083 234.892 1.00 70.36  ? 324 HIS A C     1 
ATOM 2918 O O     . HIS D 2 312 ? 182.786 237.128 234.349 1.00 70.36  ? 324 HIS A O     1 
ATOM 2919 C CB    . HIS D 2 312 ? 181.513 237.225 237.395 1.00 70.36  ? 324 HIS A CB    1 
ATOM 2920 C CG    . HIS D 2 312 ? 181.390 238.091 238.609 1.00 70.36  ? 324 HIS A CG    1 
ATOM 2921 N ND1   . HIS D 2 312 ? 180.973 237.607 239.830 1.00 70.36  ? 324 HIS A ND1   1 
ATOM 2922 C CD2   . HIS D 2 312 ? 181.626 239.412 238.788 1.00 70.36  ? 324 HIS A CD2   1 
ATOM 2923 C CE1   . HIS D 2 312 ? 180.960 238.593 240.710 1.00 70.36  ? 324 HIS A CE1   1 
ATOM 2924 N NE2   . HIS D 2 312 ? 181.352 239.698 240.103 1.00 70.36  ? 324 HIS A NE2   1 
ATOM 2925 N N     . LYS D 2 313 ? 180.713 236.258 234.474 1.00 69.08  ? 325 LYS A N     1 
ATOM 2926 C CA    . LYS D 2 313 ? 180.928 235.409 233.307 1.00 69.08  ? 325 LYS A CA    1 
ATOM 2927 C C     . LYS D 2 313 ? 181.103 236.246 232.046 1.00 69.08  ? 325 LYS A C     1 
ATOM 2928 O O     . LYS D 2 313 ? 181.932 235.922 231.186 1.00 69.08  ? 325 LYS A O     1 
ATOM 2929 C CB    . LYS D 2 313 ? 179.768 234.427 233.147 1.00 69.08  ? 325 LYS A CB    1 
ATOM 2930 C CG    . LYS D 2 313 ? 180.050 233.294 232.172 1.00 69.08  ? 325 LYS A CG    1 
ATOM 2931 C CD    . LYS D 2 313 ? 178.884 232.323 232.091 1.00 69.08  ? 325 LYS A CD    1 
ATOM 2932 C CE    . LYS D 2 313 ? 179.000 231.222 233.131 1.00 69.08  ? 325 LYS A CE    1 
ATOM 2933 N NZ    . LYS D 2 313 ? 180.352 230.603 233.133 1.00 69.08  ? 325 LYS A NZ    1 
ATOM 2934 N N     . SER D 2 314 ? 180.329 237.326 231.916 1.00 72.61  ? 326 SER A N     1 
ATOM 2935 C CA    . SER D 2 314 ? 180.487 238.214 230.769 1.00 72.61  ? 326 SER A CA    1 
ATOM 2936 C C     . SER D 2 314 ? 181.862 238.870 230.766 1.00 72.61  ? 326 SER A C     1 
ATOM 2937 O O     . SER D 2 314 ? 182.488 239.005 229.711 1.00 72.61  ? 326 SER A O     1 
ATOM 2938 C CB    . SER D 2 314 ? 179.387 239.275 230.767 1.00 72.61  ? 326 SER A CB    1 
ATOM 2939 O OG    . SER D 2 314 ? 179.473 240.102 231.913 1.00 72.61  ? 326 SER A OG    1 
ATOM 2940 N N     . GLN D 2 315 ? 182.344 239.288 231.938 1.00 73.05  ? 327 GLN A N     1 
ATOM 2941 C CA    . GLN D 2 315 ? 183.681 239.870 232.024 1.00 73.05  ? 327 GLN A CA    1 
ATOM 2942 C C     . GLN D 2 315 ? 184.750 238.851 231.648 1.00 73.05  ? 327 GLN A C     1 
ATOM 2943 O O     . GLN D 2 315 ? 185.712 239.177 230.939 1.00 73.05  ? 327 GLN A O     1 
ATOM 2944 C CB    . GLN D 2 315 ? 183.924 240.413 233.433 1.00 73.05  ? 327 GLN A CB    1 
ATOM 2945 C CG    . GLN D 2 315 ? 185.385 240.648 233.772 1.00 73.05  ? 327 GLN A CG    1 
ATOM 2946 C CD    . GLN D 2 315 ? 185.656 240.584 235.262 1.00 73.05  ? 327 GLN A CD    1 
ATOM 2947 O OE1   . GLN D 2 315 ? 184.984 241.243 236.055 1.00 73.05  ? 327 GLN A OE1   1 
ATOM 2948 N NE2   . GLN D 2 315 ? 186.647 239.791 235.650 1.00 73.05  ? 327 GLN A NE2   1 
ATOM 2949 N N     . LEU D 2 316 ? 184.597 237.609 232.112 1.00 71.49  ? 328 LEU A N     1 
ATOM 2950 C CA    . LEU D 2 316 ? 185.548 236.561 231.753 1.00 71.49  ? 328 LEU A CA    1 
ATOM 2951 C C     . LEU D 2 316 ? 185.551 236.310 230.251 1.00 71.49  ? 328 LEU A C     1 
ATOM 2952 O O     . LEU D 2 316 ? 186.616 236.179 229.635 1.00 71.49  ? 328 LEU A O     1 
ATOM 2953 C CB    . LEU D 2 316 ? 185.218 235.277 232.513 1.00 71.49  ? 328 LEU A CB    1 
ATOM 2954 C CG    . LEU D 2 316 ? 186.239 234.142 232.432 1.00 71.49  ? 328 LEU A CG    1 
ATOM 2955 C CD1   . LEU D 2 316 ? 186.526 233.587 233.816 1.00 71.49  ? 328 LEU A CD1   1 
ATOM 2956 C CD2   . LEU D 2 316 ? 185.742 233.045 231.507 1.00 71.49  ? 328 LEU A CD2   1 
ATOM 2957 N N     . VAL D 2 317 ? 184.365 236.252 229.642 1.00 73.00  ? 329 VAL A N     1 
ATOM 2958 C CA    . VAL D 2 317 ? 184.271 236.028 228.202 1.00 73.00  ? 329 VAL A CA    1 
ATOM 2959 C C     . VAL D 2 317 ? 184.885 237.195 227.439 1.00 73.00  ? 329 VAL A C     1 
ATOM 2960 O O     . VAL D 2 317 ? 185.582 237.002 226.437 1.00 73.00  ? 329 VAL A O     1 
ATOM 2961 C CB    . VAL D 2 317 ? 182.805 235.786 227.795 1.00 73.00  ? 329 VAL A CB    1 
ATOM 2962 C CG1   . VAL D 2 317 ? 182.636 235.915 226.290 1.00 73.00  ? 329 VAL A CG1   1 
ATOM 2963 C CG2   . VAL D 2 317 ? 182.347 234.416 228.266 1.00 73.00  ? 329 VAL A CG2   1 
ATOM 2964 N N     . TRP D 2 318 ? 184.637 238.423 227.899 1.00 72.31  ? 330 TRP A N     1 
ATOM 2965 C CA    . TRP D 2 318 ? 185.204 239.597 227.243 1.00 72.31  ? 330 TRP A CA    1 
ATOM 2966 C C     . TRP D 2 318 ? 186.726 239.586 227.305 1.00 72.31  ? 330 TRP A C     1 
ATOM 2967 O O     . TRP D 2 318 ? 187.400 239.854 226.301 1.00 72.31  ? 330 TRP A O     1 
ATOM 2968 C CB    . TRP D 2 318 ? 184.646 240.865 227.890 1.00 72.31  ? 330 TRP A CB    1 
ATOM 2969 C CG    . TRP D 2 318 ? 185.179 242.139 227.316 1.00 72.31  ? 330 TRP A CG    1 
ATOM 2970 C CD1   . TRP D 2 318 ? 184.645 242.861 226.290 1.00 72.31  ? 330 TRP A CD1   1 
ATOM 2971 C CD2   . TRP D 2 318 ? 186.344 242.853 227.745 1.00 72.31  ? 330 TRP A CD2   1 
ATOM 2972 N NE1   . TRP D 2 318 ? 185.409 243.976 226.049 1.00 72.31  ? 330 TRP A NE1   1 
ATOM 2973 C CE2   . TRP D 2 318 ? 186.458 243.994 226.929 1.00 72.31  ? 330 TRP A CE2   1 
ATOM 2974 C CE3   . TRP D 2 318 ? 187.303 242.635 228.738 1.00 72.31  ? 330 TRP A CE3   1 
ATOM 2975 C CZ2   . TRP D 2 318 ? 187.493 244.914 227.075 1.00 72.31  ? 330 TRP A CZ2   1 
ATOM 2976 C CZ3   . TRP D 2 318 ? 188.329 243.548 228.880 1.00 72.31  ? 330 TRP A CZ3   1 
ATOM 2977 C CH2   . TRP D 2 318 ? 188.416 244.674 228.054 1.00 72.31  ? 330 TRP A CH2   1 
ATOM 2978 N N     . MET D 2 319 ? 187.287 239.273 228.476 1.00 72.76  ? 331 MET A N     1 
ATOM 2979 C CA    . MET D 2 319 ? 188.739 239.229 228.605 1.00 72.76  ? 331 MET A CA    1 
ATOM 2980 C C     . MET D 2 319 ? 189.334 238.109 227.762 1.00 72.76  ? 331 MET A C     1 
ATOM 2981 O O     . MET D 2 319 ? 190.408 238.274 227.172 1.00 72.76  ? 331 MET A O     1 
ATOM 2982 C CB    . MET D 2 319 ? 189.141 239.070 230.069 1.00 72.76  ? 331 MET A CB    1 
ATOM 2983 C CG    . MET D 2 319 ? 189.018 240.346 230.884 1.00 72.76  ? 331 MET A CG    1 
ATOM 2984 S SD    . MET D 2 319 ? 189.039 240.014 232.651 1.00 72.76  ? 331 MET A SD    1 
ATOM 2985 C CE    . MET D 2 319 ? 190.053 238.542 232.672 1.00 72.76  ? 331 MET A CE    1 
ATOM 2986 N N     . ALA D 2 320 ? 188.658 236.961 227.700 1.00 71.80  ? 332 ALA A N     1 
ATOM 2987 C CA    . ALA D 2 320 ? 189.118 235.884 226.831 1.00 71.80  ? 332 ALA A CA    1 
ATOM 2988 C C     . ALA D 2 320 ? 189.091 236.311 225.369 1.00 71.80  ? 332 ALA A C     1 
ATOM 2989 O O     . ALA D 2 320 ? 190.007 235.992 224.602 1.00 71.80  ? 332 ALA A O     1 
ATOM 2990 C CB    . ALA D 2 320 ? 188.260 234.639 227.043 1.00 71.80  ? 332 ALA A CB    1 
ATOM 2991 N N     . CYS D 2 321 ? 188.042 237.030 224.966 1.00 73.61  ? 333 CYS A N     1 
ATOM 2992 C CA    . CYS D 2 321 ? 187.932 237.488 223.587 1.00 73.61  ? 333 CYS A CA    1 
ATOM 2993 C C     . CYS D 2 321 ? 189.045 238.466 223.239 1.00 73.61  ? 333 CYS A C     1 
ATOM 2994 O O     . CYS D 2 321 ? 189.641 238.382 222.159 1.00 73.61  ? 333 CYS A O     1 
ATOM 2995 C CB    . CYS D 2 321 ? 186.567 238.135 223.362 1.00 73.61  ? 333 CYS A CB    1 
ATOM 2996 S SG    . CYS D 2 321 ? 185.239 236.973 223.005 1.00 73.61  ? 333 CYS A SG    1 
ATOM 2997 N N     . HIS D 2 322 ? 189.343 239.398 224.141 1.00 73.30  ? 334 HIS A N     1 
ATOM 2998 C CA    . HIS D 2 322 ? 190.337 240.430 223.886 1.00 73.30  ? 334 HIS A CA    1 
ATOM 2999 C C     . HIS D 2 322 ? 191.717 240.075 224.426 1.00 73.30  ? 334 HIS A C     1 
ATOM 3000 O O     . HIS D 2 322 ? 192.625 240.910 224.366 1.00 73.30  ? 334 HIS A O     1 
ATOM 3001 C CB    . HIS D 2 322 ? 189.867 241.763 224.467 1.00 73.30  ? 334 HIS A CB    1 
ATOM 3002 C CG    . HIS D 2 322 ? 188.764 242.399 223.682 1.00 73.30  ? 334 HIS A CG    1 
ATOM 3003 N ND1   . HIS D 2 322 ? 187.472 242.491 224.154 1.00 73.30  ? 334 HIS A ND1   1 
ATOM 3004 C CD2   . HIS D 2 322 ? 188.756 242.963 222.451 1.00 73.30  ? 334 HIS A CD2   1 
ATOM 3005 C CE1   . HIS D 2 322 ? 186.718 243.090 223.250 1.00 73.30  ? 334 HIS A CE1   1 
ATOM 3006 N NE2   . HIS D 2 322 ? 187.472 243.386 222.207 1.00 73.30  ? 334 HIS A NE2   1 
ATOM 3007 N N     . SER D 2 323 ? 191.893 238.857 224.943 1.00 75.80  ? 335 SER A N     1 
ATOM 3008 C CA    . SER D 2 323 ? 193.181 238.388 225.461 1.00 75.80  ? 335 SER A CA    1 
ATOM 3009 C C     . SER D 2 323 ? 193.728 239.324 226.536 1.00 75.80  ? 335 SER A C     1 
ATOM 3010 O O     . SER D 2 323 ? 194.923 239.618 226.581 1.00 75.80  ? 335 SER A O     1 
ATOM 3011 C CB    . SER D 2 323 ? 194.198 238.202 224.332 1.00 75.80  ? 335 SER A CB    1 
ATOM 3012 O OG    . SER D 2 323 ? 194.687 239.450 223.875 1.00 75.80  ? 335 SER A OG    1 
ATOM 3013 N N     . ALA D 2 324 ? 192.841 239.799 227.410 1.00 73.13  ? 336 ALA A N     1 
ATOM 3014 C CA    . ALA D 2 324 ? 193.212 240.667 228.520 1.00 73.13  ? 336 ALA A CA    1 
ATOM 3015 C C     . ALA D 2 324 ? 193.290 239.909 229.840 1.00 73.13  ? 336 ALA A C     1 
ATOM 3016 O O     . ALA D 2 324 ? 193.015 240.480 230.901 1.00 73.13  ? 336 ALA A O     1 
ATOM 3017 C CB    . ALA D 2 324 ? 192.230 241.832 228.634 1.00 73.13  ? 336 ALA A CB    1 
ATOM 3018 N N     . ALA D 2 325 ? 193.653 238.625 229.792 1.00 70.77  ? 337 ALA A N     1 
ATOM 3019 C CA    . ALA D 2 325 ? 193.743 237.833 231.014 1.00 70.77  ? 337 ALA A CA    1 
ATOM 3020 C C     . ALA D 2 325 ? 194.837 238.356 231.937 1.00 70.77  ? 337 ALA A C     1 
ATOM 3021 O O     . ALA D 2 325 ? 194.646 238.428 233.156 1.00 70.77  ? 337 ALA A O     1 
ATOM 3022 C CB    . ALA D 2 325 ? 193.988 236.365 230.671 1.00 70.77  ? 337 ALA A CB    1 
ATOM 3023 N N     . PHE D 2 326 ? 195.987 238.722 231.377 1.00 68.15  ? 338 PHE A N     1 
ATOM 3024 C CA    . PHE D 2 326 ? 197.105 239.239 232.153 1.00 68.15  ? 338 PHE A CA    1 
ATOM 3025 C C     . PHE D 2 326 ? 197.256 240.750 232.035 1.00 68.15  ? 338 PHE A C     1 
ATOM 3026 O O     . PHE D 2 326 ? 198.258 241.300 232.501 1.00 68.15  ? 338 PHE A O     1 
ATOM 3027 C CB    . PHE D 2 326 ? 198.402 238.553 231.727 1.00 68.15  ? 338 PHE A CB    1 
ATOM 3028 C CG    . PHE D 2 326 ? 198.310 237.057 231.670 1.00 68.15  ? 338 PHE A CG    1 
ATOM 3029 C CD1   . PHE D 2 326 ? 197.894 236.332 232.772 1.00 68.15  ? 338 PHE A CD1   1 
ATOM 3030 C CD2   . PHE D 2 326 ? 198.643 236.376 230.513 1.00 68.15  ? 338 PHE A CD2   1 
ATOM 3031 C CE1   . PHE D 2 326 ? 197.813 234.955 232.721 1.00 68.15  ? 338 PHE A CE1   1 
ATOM 3032 C CE2   . PHE D 2 326 ? 198.562 234.999 230.456 1.00 68.15  ? 338 PHE A CE2   1 
ATOM 3033 C CZ    . PHE D 2 326 ? 198.146 234.289 231.562 1.00 68.15  ? 338 PHE A CZ    1 
ATOM 3034 N N     . GLU D 2 327 ? 196.253 241.402 231.438 1.00 71.99  ? 339 GLU A N     1 
ATOM 3035 C CA    . GLU D 2 327 ? 196.298 242.877 231.261 1.00 71.99  ? 339 GLU A CA    1 
ATOM 3036 C C     . GLU D 2 327 ? 196.035 243.568 232.601 1.00 71.99  ? 339 GLU A C     1 
ATOM 3037 O O     . GLU D 2 327 ? 195.318 242.984 233.437 1.00 71.99  ? 339 GLU A O     1 
ATOM 3038 C CB    . GLU D 2 327 ? 195.278 243.328 230.214 1.00 71.99  ? 339 GLU A CB    1 
ATOM 3039 C CG    . GLU D 2 327 ? 195.544 244.725 229.682 1.00 71.99  ? 339 GLU A CG    1 
ATOM 3040 C CD    . GLU D 2 327 ? 197.002 245.146 229.754 1.00 71.99  ? 339 GLU A CD    1 
ATOM 3041 O OE1   . GLU D 2 327 ? 197.839 244.462 229.144 1.00 71.99  ? 339 GLU A OE1   1 
ATOM 3042 O OE2   . GLU D 2 327 ? 197.298 246.149 230.431 1.00 71.99  ? 339 GLU A OE2   1 
ATOM 3043 N N     . ASP D 2 328 ? 196.589 244.768 232.788 1.00 71.66  ? 340 ASP A N     1 
ATOM 3044 C CA    . ASP D 2 328 ? 196.398 245.516 234.022 1.00 71.66  ? 340 ASP A CA    1 
ATOM 3045 C C     . ASP D 2 328 ? 194.915 245.715 234.302 1.00 71.66  ? 340 ASP A C     1 
ATOM 3046 O O     . ASP D 2 328 ? 194.125 246.006 233.400 1.00 71.66  ? 340 ASP A O     1 
ATOM 3047 C CB    . ASP D 2 328 ? 197.111 246.865 233.937 1.00 71.66  ? 340 ASP A CB    1 
ATOM 3048 C CG    . ASP D 2 328 ? 197.253 247.535 235.286 1.00 71.66  ? 340 ASP A CG    1 
ATOM 3049 O OD1   . ASP D 2 328 ? 196.803 246.952 236.293 1.00 71.66  ? 340 ASP A OD1   1 
ATOM 3050 O OD2   . ASP D 2 328 ? 197.817 248.648 235.338 1.00 71.66  ? 340 ASP A OD2   1 
ATOM 3051 N N     . LEU D 2 329 ? 194.540 245.542 235.570 1.00 73.21  ? 341 LEU A N     1 
ATOM 3052 C CA    . LEU D 2 329 ? 193.135 245.642 235.948 1.00 73.21  ? 341 LEU A CA    1 
ATOM 3053 C C     . LEU D 2 329 ? 192.604 247.052 235.730 1.00 73.21  ? 341 LEU A C     1 
ATOM 3054 O O     . LEU D 2 329 ? 191.469 247.233 235.274 1.00 73.21  ? 341 LEU A O     1 
ATOM 3055 C CB    . LEU D 2 329 ? 192.955 245.217 237.404 1.00 73.21  ? 341 LEU A CB    1 
ATOM 3056 C CG    . LEU D 2 329 ? 192.521 243.769 237.632 1.00 73.21  ? 341 LEU A CG    1 
ATOM 3057 C CD1   . LEU D 2 329 ? 191.083 243.577 237.210 1.00 73.21  ? 341 LEU A CD1   1 
ATOM 3058 C CD2   . LEU D 2 329 ? 193.423 242.814 236.877 1.00 73.21  ? 341 LEU A CD2   1 
ATOM 3059 N N     . ARG D 2 330 ? 193.410 248.065 236.053 1.00 73.24  ? 342 ARG A N     1 
ATOM 3060 C CA    . ARG D 2 330 ? 192.957 249.445 235.912 1.00 73.24  ? 342 ARG A CA    1 
ATOM 3061 C C     . ARG D 2 330 ? 192.710 249.807 234.453 1.00 73.24  ? 342 ARG A C     1 
ATOM 3062 O O     . ARG D 2 330 ? 191.669 250.384 234.119 1.00 73.24  ? 342 ARG A O     1 
ATOM 3063 C CB    . ARG D 2 330 ? 193.977 250.394 236.540 1.00 73.24  ? 342 ARG A CB    1 
ATOM 3064 C CG    . ARG D 2 330 ? 194.285 250.089 237.996 1.00 73.24  ? 342 ARG A CG    1 
ATOM 3065 C CD    . ARG D 2 330 ? 195.456 250.913 238.500 1.00 73.24  ? 342 ARG A CD    1 
ATOM 3066 N NE    . ARG D 2 330 ? 196.716 250.194 238.366 1.00 73.24  ? 342 ARG A NE    1 
ATOM 3067 C CZ    . ARG D 2 330 ? 197.748 250.621 237.652 1.00 73.24  ? 342 ARG A CZ    1 
ATOM 3068 N NH1   . ARG D 2 330 ? 197.705 251.768 236.994 1.00 73.24  ? 342 ARG A NH1   1 
ATOM 3069 N NH2   . ARG D 2 330 ? 198.848 249.877 237.594 1.00 73.24  ? 342 ARG A NH2   1 
ATOM 3070 N N     . VAL D 2 331 ? 193.651 249.474 233.566 1.00 72.58  ? 343 VAL A N     1 
ATOM 3071 C CA    . VAL D 2 331 ? 193.477 249.818 232.156 1.00 72.58  ? 343 VAL A CA    1 
ATOM 3072 C C     . VAL D 2 331 ? 192.349 248.996 231.543 1.00 72.58  ? 343 VAL A C     1 
ATOM 3073 O O     . VAL D 2 331 ? 191.607 249.481 230.681 1.00 72.58  ? 343 VAL A O     1 
ATOM 3074 C CB    . VAL D 2 331 ? 194.802 249.654 231.384 1.00 72.58  ? 343 VAL A CB    1 
ATOM 3075 C CG1   . VAL D 2 331 ? 195.208 248.200 231.294 1.00 72.58  ? 343 VAL A CG1   1 
ATOM 3076 C CG2   . VAL D 2 331 ? 194.689 250.266 229.996 1.00 72.58  ? 343 VAL A CG2   1 
ATOM 3077 N N     . SER D 2 332 ? 192.196 247.742 231.979 1.00 72.64  ? 344 SER A N     1 
ATOM 3078 C CA    . SER D 2 332 ? 191.088 246.925 231.492 1.00 72.64  ? 344 SER A CA    1 
ATOM 3079 C C     . SER D 2 332 ? 189.747 247.517 231.906 1.00 72.64  ? 344 SER A C     1 
ATOM 3080 O O     . SER D 2 332 ? 188.807 247.569 231.103 1.00 72.64  ? 344 SER A O     1 
ATOM 3081 C CB    . SER D 2 332 ? 191.225 245.493 232.006 1.00 72.64  ? 344 SER A CB    1 
ATOM 3082 O OG    . SER D 2 332 ? 192.354 244.854 231.437 1.00 72.64  ? 344 SER A OG    1 
ATOM 3083 N N     . SER D 2 333 ? 189.640 247.972 233.156 1.00 75.30  ? 345 SER A N     1 
ATOM 3084 C CA    . SER D 2 333 ? 188.409 248.608 233.612 1.00 75.30  ? 345 SER A CA    1 
ATOM 3085 C C     . SER D 2 333 ? 188.153 249.907 232.862 1.00 75.30  ? 345 SER A C     1 
ATOM 3086 O O     . SER D 2 333 ? 187.006 250.224 232.524 1.00 75.30  ? 345 SER A O     1 
ATOM 3087 C CB    . SER D 2 333 ? 188.477 248.861 235.117 1.00 75.30  ? 345 SER A CB    1 
ATOM 3088 O OG    . SER D 2 333 ? 188.569 247.644 235.836 1.00 75.30  ? 345 SER A OG    1 
ATOM 3089 N N     . PHE D 2 334 ? 189.211 250.677 232.601 1.00 75.02  ? 346 PHE A N     1 
ATOM 3090 C CA    . PHE D 2 334 ? 189.056 251.928 231.867 1.00 75.02  ? 346 PHE A CA    1 
ATOM 3091 C C     . PHE D 2 334 ? 188.576 251.678 230.442 1.00 75.02  ? 346 PHE A C     1 
ATOM 3092 O O     . PHE D 2 334 ? 187.710 252.401 229.937 1.00 75.02  ? 346 PHE A O     1 
ATOM 3093 C CB    . PHE D 2 334 ? 190.379 252.693 231.867 1.00 75.02  ? 346 PHE A CB    1 
ATOM 3094 C CG    . PHE D 2 334 ? 190.282 254.073 231.289 1.00 75.02  ? 346 PHE A CG    1 
ATOM 3095 C CD1   . PHE D 2 334 ? 189.679 255.093 232.003 1.00 75.02  ? 346 PHE A CD1   1 
ATOM 3096 C CD2   . PHE D 2 334 ? 190.800 254.353 230.038 1.00 75.02  ? 346 PHE A CD2   1 
ATOM 3097 C CE1   . PHE D 2 334 ? 189.590 256.366 231.479 1.00 75.02  ? 346 PHE A CE1   1 
ATOM 3098 C CE2   . PHE D 2 334 ? 190.714 255.624 229.508 1.00 75.02  ? 346 PHE A CE2   1 
ATOM 3099 C CZ    . PHE D 2 334 ? 190.108 256.632 230.229 1.00 75.02  ? 346 PHE A CZ    1 
ATOM 3100 N N     . ILE D 2 335 ? 189.128 250.660 229.780 1.00 74.70  ? 347 ILE A N     1 
ATOM 3101 C CA    . ILE D 2 335 ? 188.730 250.352 228.410 1.00 74.70  ? 347 ILE A CA    1 
ATOM 3102 C C     . ILE D 2 335 ? 187.301 249.823 228.375 1.00 74.70  ? 347 ILE A C     1 
ATOM 3103 O O     . ILE D 2 335 ? 186.483 250.252 227.553 1.00 74.70  ? 347 ILE A O     1 
ATOM 3104 C CB    . ILE D 2 335 ? 189.719 249.356 227.780 1.00 74.70  ? 347 ILE A CB    1 
ATOM 3105 C CG1   . ILE D 2 335 ? 191.066 250.035 227.531 1.00 74.70  ? 347 ILE A CG1   1 
ATOM 3106 C CG2   . ILE D 2 335 ? 189.162 248.791 226.486 1.00 74.70  ? 347 ILE A CG2   1 
ATOM 3107 C CD1   . ILE D 2 335 ? 192.123 249.108 226.992 1.00 74.70  ? 347 ILE A CD1   1 
ATOM 3108 N N     . ARG D 2 336 ? 186.979 248.885 229.268 1.00 75.03  ? 348 ARG A N     1 
ATOM 3109 C CA    . ARG D 2 336 ? 185.631 248.328 229.299 1.00 75.03  ? 348 ARG A CA    1 
ATOM 3110 C C     . ARG D 2 336 ? 184.614 249.335 229.820 1.00 75.03  ? 348 ARG A C     1 
ATOM 3111 O O     . ARG D 2 336 ? 183.447 249.302 229.415 1.00 75.03  ? 348 ARG A O     1 
ATOM 3112 C CB    . ARG D 2 336 ? 185.610 247.061 230.154 1.00 75.03  ? 348 ARG A CB    1 
ATOM 3113 C CG    . ARG D 2 336 ? 184.274 246.336 230.168 1.00 75.03  ? 348 ARG A CG    1 
ATOM 3114 C CD    . ARG D 2 336 ? 184.387 244.988 230.858 1.00 75.03  ? 348 ARG A CD    1 
ATOM 3115 N NE    . ARG D 2 336 ? 183.084 244.365 231.057 1.00 75.03  ? 348 ARG A NE    1 
ATOM 3116 C CZ    . ARG D 2 336 ? 182.407 243.728 230.112 1.00 75.03  ? 348 ARG A CZ    1 
ATOM 3117 N NH1   . ARG D 2 336 ? 182.879 243.610 228.882 1.00 75.03  ? 348 ARG A NH1   1 
ATOM 3118 N NH2   . ARG D 2 336 ? 181.225 243.195 230.409 1.00 75.03  ? 348 ARG A NH2   1 
ATOM 3119 N N     . GLY D 2 337 ? 185.032 250.236 230.708 1.00 77.86  ? 349 GLY A N     1 
ATOM 3120 C CA    . GLY D 2 337 ? 184.132 251.182 231.326 1.00 77.86  ? 349 GLY A CA    1 
ATOM 3121 C C     . GLY D 2 337 ? 183.485 250.695 232.602 1.00 77.86  ? 349 GLY A C     1 
ATOM 3122 O O     . GLY D 2 337 ? 182.816 251.484 233.280 1.00 77.86  ? 349 GLY A O     1 
ATOM 3123 N N     . THR D 2 338 ? 183.663 249.424 232.949 1.00 78.65  ? 350 THR A N     1 
ATOM 3124 C CA    . THR D 2 338 ? 183.163 248.858 234.191 1.00 78.65  ? 350 THR A CA    1 
ATOM 3125 C C     . THR D 2 338 ? 184.325 248.207 234.923 1.00 78.65  ? 350 THR A C     1 
ATOM 3126 O O     . THR D 2 338 ? 185.183 247.576 234.299 1.00 78.65  ? 350 THR A O     1 
ATOM 3127 C CB    . THR D 2 338 ? 182.051 247.833 233.934 1.00 78.65  ? 350 THR A CB    1 
ATOM 3128 O OG1   . THR D 2 338 ? 181.054 248.413 233.083 1.00 78.65  ? 350 THR A OG1   1 
ATOM 3129 C CG2   . THR D 2 338 ? 181.402 247.405 235.241 1.00 78.65  ? 350 THR A CG2   1 
ATOM 3130 N N     . LYS D 2 339 ? 184.356 248.374 236.243 1.00 76.13  ? 351 LYS A N     1 
ATOM 3131 C CA    . LYS D 2 339 ? 185.482 247.891 237.032 1.00 76.13  ? 351 LYS A CA    1 
ATOM 3132 C C     . LYS D 2 339 ? 185.572 246.373 236.923 1.00 76.13  ? 351 LYS A C     1 
ATOM 3133 O O     . LYS D 2 339 ? 184.591 245.660 237.152 1.00 76.13  ? 351 LYS A O     1 
ATOM 3134 C CB    . LYS D 2 339 ? 185.323 248.368 238.484 1.00 76.13  ? 351 LYS A CB    1 
ATOM 3135 C CG    . LYS D 2 339 ? 185.310 249.877 238.792 1.00 76.13  ? 351 LYS A CG    1 
ATOM 3136 C CD    . LYS D 2 339 ? 185.219 250.252 240.266 1.00 76.13  ? 351 LYS A CD    1 
ATOM 3137 C CE    . LYS D 2 339 ? 186.523 249.928 240.977 1.00 76.13  ? 351 LYS A CE    1 
ATOM 3138 N NZ    . LYS D 2 339 ? 187.646 250.793 240.534 1.00 76.13  ? 351 LYS A NZ    1 
ATOM 3139 N N     . VAL D 2 340 ? 186.754 245.885 236.560 1.00 72.60  ? 352 VAL A N     1 
ATOM 3140 C CA    . VAL D 2 340 ? 186.960 244.475 236.250 1.00 72.60  ? 352 VAL A CA    1 
ATOM 3141 C C     . VAL D 2 340 ? 187.291 243.724 237.531 1.00 72.60  ? 352 VAL A C     1 
ATOM 3142 O O     . VAL D 2 340 ? 188.167 244.139 238.299 1.00 72.60  ? 352 VAL A O     1 
ATOM 3143 C CB    . VAL D 2 340 ? 188.073 244.299 235.204 1.00 72.60  ? 352 VAL A CB    1 
ATOM 3144 C CG1   . VAL D 2 340 ? 188.298 242.827 234.910 1.00 72.60  ? 352 VAL A CG1   1 
ATOM 3145 C CG2   . VAL D 2 340 ? 187.717 245.039 233.929 1.00 72.60  ? 352 VAL A CG2   1 
ATOM 3146 N N     . VAL D 2 341 ? 186.585 242.623 237.765 1.00 68.99  ? 353 VAL A N     1 
ATOM 3147 C CA    . VAL D 2 341 ? 186.782 241.816 238.965 1.00 68.99  ? 353 VAL A CA    1 
ATOM 3148 C C     . VAL D 2 341 ? 187.904 240.816 238.713 1.00 68.99  ? 353 VAL A C     1 
ATOM 3149 O O     . VAL D 2 341 ? 187.839 240.043 237.746 1.00 68.99  ? 353 VAL A O     1 
ATOM 3150 C CB    . VAL D 2 341 ? 185.485 241.102 239.376 1.00 68.99  ? 353 VAL A CB    1 
ATOM 3151 C CG1   . VAL D 2 341 ? 185.775 240.024 240.406 1.00 68.99  ? 353 VAL A CG1   1 
ATOM 3152 C CG2   . VAL D 2 341 ? 184.475 242.103 239.911 1.00 68.99  ? 353 VAL A CG2   1 
ATOM 3153 N N     . PRO D 2 342 ? 188.946 240.796 239.542 1.00 67.45  ? 354 PRO A N     1 
ATOM 3154 C CA    . PRO D 2 342 ? 190.002 239.791 239.382 1.00 67.45  ? 354 PRO A CA    1 
ATOM 3155 C C     . PRO D 2 342 ? 189.476 238.387 239.646 1.00 67.45  ? 354 PRO A C     1 
ATOM 3156 O O     . PRO D 2 342 ? 188.377 238.180 240.164 1.00 67.45  ? 354 PRO A O     1 
ATOM 3157 C CB    . PRO D 2 342 ? 191.056 240.207 240.414 1.00 67.45  ? 354 PRO A CB    1 
ATOM 3158 C CG    . PRO D 2 342 ? 190.325 241.073 241.385 1.00 67.45  ? 354 PRO A CG    1 
ATOM 3159 C CD    . PRO D 2 342 ? 189.264 241.771 240.597 1.00 67.45  ? 354 PRO A CD    1 
ATOM 3160 N N     . ARG D 2 343 ? 190.296 237.402 239.270 1.00 64.60  ? 355 ARG A N     1 
ATOM 3161 C CA    . ARG D 2 343 ? 189.865 236.008 239.318 1.00 64.60  ? 355 ARG A CA    1 
ATOM 3162 C C     . ARG D 2 343 ? 189.555 235.557 240.739 1.00 64.60  ? 355 ARG A C     1 
ATOM 3163 O O     . ARG D 2 343 ? 188.784 234.610 240.934 1.00 64.60  ? 355 ARG A O     1 
ATOM 3164 C CB    . ARG D 2 343 ? 190.938 235.112 238.698 1.00 64.60  ? 355 ARG A CB    1 
ATOM 3165 C CG    . ARG D 2 343 ? 190.524 233.662 238.506 1.00 64.60  ? 355 ARG A CG    1 
ATOM 3166 C CD    . ARG D 2 343 ? 189.323 233.548 237.586 1.00 64.60  ? 355 ARG A CD    1 
ATOM 3167 N NE    . ARG D 2 343 ? 188.923 232.162 237.376 1.00 64.60  ? 355 ARG A NE    1 
ATOM 3168 C CZ    . ARG D 2 343 ? 187.994 231.533 238.083 1.00 64.60  ? 355 ARG A CZ    1 
ATOM 3169 N NH1   . ARG D 2 343 ? 187.338 232.141 239.057 1.00 64.60  ? 355 ARG A NH1   1 
ATOM 3170 N NH2   . ARG D 2 343 ? 187.715 230.264 237.804 1.00 64.60  ? 355 ARG A NH2   1 
ATOM 3171 N N     . GLY D 2 344 ? 190.137 236.219 241.740 1.00 69.84  ? 356 GLY A N     1 
ATOM 3172 C CA    . GLY D 2 344 ? 189.942 235.784 243.113 1.00 69.84  ? 356 GLY A CA    1 
ATOM 3173 C C     . GLY D 2 344 ? 188.493 235.850 243.557 1.00 69.84  ? 356 GLY A C     1 
ATOM 3174 O O     . GLY D 2 344 ? 187.985 234.918 244.185 1.00 69.84  ? 356 GLY A O     1 
ATOM 3175 N N     . LYS D 2 345 ? 187.807 236.943 243.232 1.00 66.38  ? 357 LYS A N     1 
ATOM 3176 C CA    . LYS D 2 345 ? 186.417 237.131 243.622 1.00 66.38  ? 357 LYS A CA    1 
ATOM 3177 C C     . LYS D 2 345 ? 185.445 236.970 242.460 1.00 66.38  ? 357 LYS A C     1 
ATOM 3178 O O     . LYS D 2 345 ? 184.315 237.463 242.538 1.00 66.38  ? 357 LYS A O     1 
ATOM 3179 C CB    . LYS D 2 345 ? 186.233 238.496 244.288 1.00 66.38  ? 357 LYS A CB    1 
ATOM 3180 C CG    . LYS D 2 345 ? 187.484 239.016 244.983 1.00 66.38  ? 357 LYS A CG    1 
ATOM 3181 C CD    . LYS D 2 345 ? 187.299 240.433 245.518 1.00 66.38  ? 357 LYS A CD    1 
ATOM 3182 C CE    . LYS D 2 345 ? 186.784 241.412 244.470 1.00 66.38  ? 357 LYS A CE    1 
ATOM 3183 N NZ    . LYS D 2 345 ? 187.327 241.168 243.108 1.00 66.38  ? 357 LYS A NZ    1 
ATOM 3184 N N     . LEU D 2 346 ? 185.855 236.297 241.388 1.00 67.46  ? 358 LEU A N     1 
ATOM 3185 C CA    . LEU D 2 346 ? 184.944 235.939 240.306 1.00 67.46  ? 358 LEU A CA    1 
ATOM 3186 C C     . LEU D 2 346 ? 184.030 234.823 240.794 1.00 67.46  ? 358 LEU A C     1 
ATOM 3187 O O     . LEU D 2 346 ? 184.489 233.709 241.068 1.00 67.46  ? 358 LEU A O     1 
ATOM 3188 C CB    . LEU D 2 346 ? 185.724 235.503 239.069 1.00 67.46  ? 358 LEU A CB    1 
ATOM 3189 C CG    . LEU D 2 346 ? 186.221 236.597 238.123 1.00 67.46  ? 358 LEU A CG    1 
ATOM 3190 C CD1   . LEU D 2 346 ? 186.737 235.988 236.834 1.00 67.46  ? 358 LEU A CD1   1 
ATOM 3191 C CD2   . LEU D 2 346 ? 185.112 237.587 237.826 1.00 67.46  ? 358 LEU A CD2   1 
ATOM 3192 N N     . SER D 2 347 ? 182.737 235.116 240.907 1.00 68.99  ? 359 SER A N     1 
ATOM 3193 C CA    . SER D 2 347 ? 181.766 234.134 241.388 1.00 68.99  ? 359 SER A CA    1 
ATOM 3194 C C     . SER D 2 347 ? 181.172 233.352 240.215 1.00 68.99  ? 359 SER A C     1 
ATOM 3195 O O     . SER D 2 347 ? 179.962 233.313 239.995 1.00 68.99  ? 359 SER A O     1 
ATOM 3196 C CB    . SER D 2 347 ? 180.680 234.823 242.206 1.00 68.99  ? 359 SER A CB    1 
ATOM 3197 O OG    . SER D 2 347 ? 179.925 235.711 241.401 1.00 68.99  ? 359 SER A OG    1 
ATOM 3198 N N     . THR D 2 348 ? 182.061 232.721 239.453 1.00 68.05  ? 360 THR A N     1 
ATOM 3199 C CA    . THR D 2 348 ? 181.643 231.942 238.298 1.00 68.05  ? 360 THR A CA    1 
ATOM 3200 C C     . THR D 2 348 ? 182.692 230.881 238.009 1.00 68.05  ? 360 THR A C     1 
ATOM 3201 O O     . THR D 2 348 ? 183.886 231.091 238.232 1.00 68.05  ? 360 THR A O     1 
ATOM 3202 C CB    . THR D 2 348 ? 181.436 232.827 237.064 1.00 68.05  ? 360 THR A CB    1 
ATOM 3203 O OG1   . THR D 2 348 ? 181.343 232.004 235.895 1.00 68.05  ? 360 THR A OG1   1 
ATOM 3204 C CG2   . THR D 2 348 ? 182.599 233.789 236.902 1.00 68.05  ? 360 THR A CG2   1 
ATOM 3205 N N     . ARG D 2 349 ? 182.227 229.739 237.516 1.00 70.11  ? 361 ARG A N     1 
ATOM 3206 C CA    . ARG D 2 349 ? 183.109 228.676 237.065 1.00 70.11  ? 361 ARG A CA    1 
ATOM 3207 C C     . ARG D 2 349 ? 183.378 228.849 235.571 1.00 70.11  ? 361 ARG A C     1 
ATOM 3208 O O     . ARG D 2 349 ? 183.069 229.886 234.977 1.00 70.11  ? 361 ARG A O     1 
ATOM 3209 C CB    . ARG D 2 349 ? 182.506 227.312 237.386 1.00 70.11  ? 361 ARG A CB    1 
ATOM 3210 C CG    . ARG D 2 349 ? 182.494 226.973 238.865 1.00 70.11  ? 361 ARG A CG    1 
ATOM 3211 C CD    . ARG D 2 349 ? 181.619 225.763 239.135 1.00 70.11  ? 361 ARG A CD    1 
ATOM 3212 N NE    . ARG D 2 349 ? 181.758 224.755 238.092 1.00 70.11  ? 361 ARG A NE    1 
ATOM 3213 C CZ    . ARG D 2 349 ? 182.730 223.854 238.047 1.00 70.11  ? 361 ARG A CZ    1 
ATOM 3214 N NH1   . ARG D 2 349 ? 183.670 223.805 238.975 1.00 70.11  ? 361 ARG A NH1   1 
ATOM 3215 N NH2   . ARG D 2 349 ? 182.759 222.981 237.044 1.00 70.11  ? 361 ARG A NH2   1 
ATOM 3216 N N     . GLY D 2 350 ? 183.963 227.831 234.947 1.00 70.76  ? 362 GLY A N     1 
ATOM 3217 C CA    . GLY D 2 350 ? 184.255 227.907 233.533 1.00 70.76  ? 362 GLY A CA    1 
ATOM 3218 C C     . GLY D 2 350 ? 183.002 227.953 232.681 1.00 70.76  ? 362 GLY A C     1 
ATOM 3219 O O     . GLY D 2 350 ? 181.921 227.514 233.075 1.00 70.76  ? 362 GLY A O     1 
ATOM 3220 N N     . VAL D 2 351 ? 183.160 228.513 231.479 1.00 73.25  ? 363 VAL A N     1 
ATOM 3221 C CA    . VAL D 2 351 ? 182.038 228.629 230.556 1.00 73.25  ? 363 VAL A CA    1 
ATOM 3222 C C     . VAL D 2 351 ? 181.554 227.264 230.081 1.00 73.25  ? 363 VAL A C     1 
ATOM 3223 O O     . VAL D 2 351 ? 180.350 227.079 229.869 1.00 73.25  ? 363 VAL A O     1 
ATOM 3224 C CB    . VAL D 2 351 ? 182.419 229.538 229.370 1.00 73.25  ? 363 VAL A CB    1 
ATOM 3225 C CG1   . VAL D 2 351 ? 183.534 228.919 228.544 1.00 73.25  ? 363 VAL A CG1   1 
ATOM 3226 C CG2   . VAL D 2 351 ? 181.202 229.829 228.505 1.00 73.25  ? 363 VAL A CG2   1 
ATOM 3227 N N     . GLN D 2 352 ? 182.456 226.301 229.912 1.00 72.01  ? 364 GLN A N     1 
ATOM 3228 C CA    . GLN D 2 352 ? 182.068 224.960 229.504 1.00 72.01  ? 364 GLN A CA    1 
ATOM 3229 C C     . GLN D 2 352 ? 181.238 224.294 230.592 1.00 72.01  ? 364 GLN A C     1 
ATOM 3230 O O     . GLN D 2 352 ? 181.478 224.491 231.787 1.00 72.01  ? 364 GLN A O     1 
ATOM 3231 C CB    . GLN D 2 352 ? 183.304 224.113 229.204 1.00 72.01  ? 364 GLN A CB    1 
ATOM 3232 C CG    . GLN D 2 352 ? 184.075 224.552 227.975 1.00 72.01  ? 364 GLN A CG    1 
ATOM 3233 C CD    . GLN D 2 352 ? 184.089 223.495 226.893 1.00 72.01  ? 364 GLN A CD    1 
ATOM 3234 O OE1   . GLN D 2 352 ? 185.013 222.686 226.813 1.00 72.01  ? 364 GLN A OE1   1 
ATOM 3235 N NE2   . GLN D 2 352 ? 183.061 223.494 226.053 1.00 72.01  ? 364 GLN A NE2   1 
ATOM 3236 N N     . ILE D 2 353 ? 180.255 223.504 230.173 1.00 73.67  ? 365 ILE A N     1 
ATOM 3237 C CA    . ILE D 2 353 ? 179.401 222.758 231.088 1.00 73.67  ? 365 ILE A CA    1 
ATOM 3238 C C     . ILE D 2 353 ? 179.792 221.290 231.000 1.00 73.67  ? 365 ILE A C     1 
ATOM 3239 O O     . ILE D 2 353 ? 179.770 220.696 229.915 1.00 73.67  ? 365 ILE A O     1 
ATOM 3240 C CB    . ILE D 2 353 ? 177.914 222.960 230.762 1.00 73.67  ? 365 ILE A CB    1 
ATOM 3241 C CG1   . ILE D 2 353 ? 177.610 224.447 230.581 1.00 73.67  ? 365 ILE A CG1   1 
ATOM 3242 C CG2   . ILE D 2 353 ? 177.048 222.382 231.867 1.00 73.67  ? 365 ILE A CG2   1 
ATOM 3243 C CD1   . ILE D 2 353 ? 177.834 225.272 231.828 1.00 73.67  ? 365 ILE A CD1   1 
ATOM 3244 N N     . ALA D 2 354 ? 180.151 220.706 232.138 1.00 75.28  ? 366 ALA A N     1 
ATOM 3245 C CA    . ALA D 2 354 ? 180.640 219.337 232.161 1.00 75.28  ? 366 ALA A CA    1 
ATOM 3246 C C     . ALA D 2 354 ? 179.503 218.349 231.914 1.00 75.28  ? 366 ALA A C     1 
ATOM 3247 O O     . ALA D 2 354 ? 178.318 218.678 232.018 1.00 75.28  ? 366 ALA A O     1 
ATOM 3248 C CB    . ALA D 2 354 ? 181.320 219.034 233.495 1.00 75.28  ? 366 ALA A CB    1 
ATOM 3249 N N     . SER D 2 355 ? 179.887 217.117 231.571 1.00 74.33  ? 367 SER A N     1 
ATOM 3250 C CA    . SER D 2 355 ? 178.897 216.072 231.332 1.00 74.33  ? 367 SER A CA    1 
ATOM 3251 C C     . SER D 2 355 ? 178.130 215.732 232.604 1.00 74.33  ? 367 SER A C     1 
ATOM 3252 O O     . SER D 2 355 ? 176.910 215.533 232.568 1.00 74.33  ? 367 SER A O     1 
ATOM 3253 C CB    . SER D 2 355 ? 179.576 214.825 230.767 1.00 74.33  ? 367 SER A CB    1 
ATOM 3254 O OG    . SER D 2 355 ? 178.870 213.653 231.132 1.00 74.33  ? 367 SER A OG    1 
ATOM 3255 N N     . ASN D 2 356 ? 178.827 215.661 233.739 1.00 76.39  ? 368 ASN A N     1 
ATOM 3256 C CA    . ASN D 2 356 ? 178.198 215.321 235.015 1.00 76.39  ? 368 ASN A CA    1 
ATOM 3257 C C     . ASN D 2 356 ? 177.571 216.564 235.653 1.00 76.39  ? 368 ASN A C     1 
ATOM 3258 O O     . ASN D 2 356 ? 177.919 216.988 236.755 1.00 76.39  ? 368 ASN A O     1 
ATOM 3259 C CB    . ASN D 2 356 ? 179.213 214.668 235.945 1.00 76.39  ? 368 ASN A CB    1 
ATOM 3260 C CG    . ASN D 2 356 ? 180.497 215.466 236.061 1.00 76.39  ? 368 ASN A CG    1 
ATOM 3261 O OD1   . ASN D 2 356 ? 180.676 216.476 235.383 1.00 76.39  ? 368 ASN A OD1   1 
ATOM 3262 N ND2   . ASN D 2 356 ? 181.399 215.013 236.923 1.00 76.39  ? 368 ASN A ND2   1 
ATOM 3263 N N     . GLU D 2 357 ? 176.621 217.147 234.928 1.00 77.55  ? 369 GLU A N     1 
ATOM 3264 C CA    . GLU D 2 357 ? 175.889 218.317 235.386 1.00 77.55  ? 369 GLU A CA    1 
ATOM 3265 C C     . GLU D 2 357 ? 174.403 218.109 235.141 1.00 77.55  ? 369 GLU A C     1 
ATOM 3266 O O     . GLU D 2 357 ? 174.003 217.379 234.230 1.00 77.55  ? 369 GLU A O     1 
ATOM 3267 C CB    . GLU D 2 357 ? 176.363 219.593 234.683 1.00 77.55  ? 369 GLU A CB    1 
ATOM 3268 C CG    . GLU D 2 357 ? 177.800 219.968 234.994 1.00 77.55  ? 369 GLU A CG    1 
ATOM 3269 C CD    . GLU D 2 357 ? 177.902 221.199 235.868 1.00 77.55  ? 369 GLU A CD    1 
ATOM 3270 O OE1   . GLU D 2 357 ? 176.848 221.721 236.285 1.00 77.55  ? 369 GLU A OE1   1 
ATOM 3271 O OE2   . GLU D 2 357 ? 179.037 221.645 236.136 1.00 77.55  ? 369 GLU A OE2   1 
ATOM 3272 N N     . ASN D 2 358 ? 173.587 218.761 235.964 1.00 81.82  ? 370 ASN A N     1 
ATOM 3273 C CA    . ASN D 2 358 ? 172.140 218.605 235.908 1.00 81.82  ? 370 ASN A CA    1 
ATOM 3274 C C     . ASN D 2 358 ? 171.559 219.571 234.880 1.00 81.82  ? 370 ASN A C     1 
ATOM 3275 O O     . ASN D 2 358 ? 171.918 220.754 234.857 1.00 81.82  ? 370 ASN A O     1 
ATOM 3276 C CB    . ASN D 2 358 ? 171.528 218.821 237.295 1.00 81.82  ? 370 ASN A CB    1 
ATOM 3277 C CG    . ASN D 2 358 ? 171.282 220.285 237.616 1.00 81.82  ? 370 ASN A CG    1 
ATOM 3278 O OD1   . ASN D 2 358 ? 170.291 220.872 237.180 1.00 81.82  ? 370 ASN A OD1   1 
ATOM 3279 N ND2   . ASN D 2 358 ? 172.189 220.883 238.379 1.00 81.82  ? 370 ASN A ND2   1 
ATOM 3280 N N     . MET D 2 359 ? 170.698 219.057 234.007 1.00 86.42  ? 371 MET A N     1 
ATOM 3281 C CA    . MET D 2 359 ? 169.981 219.889 233.040 1.00 86.42  ? 371 MET A CA    1 
ATOM 3282 C C     . MET D 2 359 ? 168.612 220.304 233.570 1.00 86.42  ? 371 MET A C     1 
ATOM 3283 O O     . MET D 2 359 ? 167.595 220.189 232.888 1.00 86.42  ? 371 MET A O     1 
ATOM 3284 C CB    . MET D 2 359 ? 169.854 219.140 231.718 1.00 86.42  ? 371 MET A CB    1 
ATOM 3285 C CG    . MET D 2 359 ? 171.157 218.849 230.940 1.00 86.42  ? 371 MET A CG    1 
ATOM 3286 S SD    . MET D 2 359 ? 172.696 219.795 231.147 1.00 86.42  ? 371 MET A SD    1 
ATOM 3287 C CE    . MET D 2 359 ? 172.176 221.513 231.203 1.00 86.42  ? 371 MET A CE    1 
ATOM 3288 N N     . GLU D 2 360 ? 168.583 220.799 234.807 1.00 85.72  ? 372 GLU A N     1 
ATOM 3289 C CA    . GLU D 2 360 ? 167.340 221.262 235.418 1.00 85.72  ? 372 GLU A CA    1 
ATOM 3290 C C     . GLU D 2 360 ? 167.459 222.582 236.163 1.00 85.72  ? 372 GLU A C     1 
ATOM 3291 O O     . GLU D 2 360 ? 166.425 223.204 236.429 1.00 85.72  ? 372 GLU A O     1 
ATOM 3292 C CB    . GLU D 2 360 ? 166.777 220.203 236.378 1.00 85.72  ? 372 GLU A CB    1 
ATOM 3293 C CG    . GLU D 2 360 ? 165.435 220.559 237.018 1.00 85.72  ? 372 GLU A CG    1 
ATOM 3294 C CD    . GLU D 2 360 ? 164.891 219.468 237.921 1.00 85.72  ? 372 GLU A CD    1 
ATOM 3295 O OE1   . GLU D 2 360 ? 165.570 218.434 238.091 1.00 85.72  ? 372 GLU A OE1   1 
ATOM 3296 O OE2   . GLU D 2 360 ? 163.779 219.645 238.462 1.00 85.72  ? 372 GLU A OE2   1 
ATOM 3297 N N     . THR D 2 361 ? 168.659 223.038 236.519 1.00 85.00  ? 373 THR A N     1 
ATOM 3298 C CA    . THR D 2 361 ? 168.836 224.272 237.271 1.00 85.00  ? 373 THR A CA    1 
ATOM 3299 C C     . THR D 2 361 ? 169.684 225.300 236.532 1.00 85.00  ? 373 THR A C     1 
ATOM 3300 O O     . THR D 2 361 ? 170.256 226.189 237.172 1.00 85.00  ? 373 THR A O     1 
ATOM 3301 C CB    . THR D 2 361 ? 169.461 223.975 238.637 1.00 85.00  ? 373 THR A CB    1 
ATOM 3302 O OG1   . THR D 2 361 ? 170.822 223.563 238.463 1.00 85.00  ? 373 THR A OG1   1 
ATOM 3303 C CG2   . THR D 2 361 ? 168.690 222.876 239.352 1.00 85.00  ? 373 THR A CG2   1 
ATOM 3304 N N     . MET D 2 362 ? 169.779 225.206 235.209 1.00 80.69  ? 374 MET A N     1 
ATOM 3305 C CA    . MET D 2 362 ? 170.610 226.106 234.422 1.00 80.69  ? 374 MET A CA    1 
ATOM 3306 C C     . MET D 2 362 ? 169.742 227.125 233.694 1.00 80.69  ? 374 MET A C     1 
ATOM 3307 O O     . MET D 2 362 ? 168.669 226.792 233.183 1.00 80.69  ? 374 MET A O     1 
ATOM 3308 C CB    . MET D 2 362 ? 171.458 225.326 233.417 1.00 80.69  ? 374 MET A CB    1 
ATOM 3309 C CG    . MET D 2 362 ? 172.143 224.104 234.011 1.00 80.69  ? 374 MET A CG    1 
ATOM 3310 S SD    . MET D 2 362 ? 173.792 223.807 233.348 1.00 80.69  ? 374 MET A SD    1 
ATOM 3311 C CE    . MET D 2 362 ? 174.789 224.760 234.487 1.00 80.69  ? 374 MET A CE    1 
ATOM 3312 N N     . GLU D 2 363 ? 170.216 228.368 233.649 1.00 78.61  ? 375 GLU A N     1 
ATOM 3313 C CA    . GLU D 2 363 ? 169.515 229.457 232.988 1.00 78.61  ? 375 GLU A CA    1 
ATOM 3314 C C     . GLU D 2 363 ? 170.438 230.120 231.975 1.00 78.61  ? 375 GLU A C     1 
ATOM 3315 O O     . GLU D 2 363 ? 171.663 229.996 232.045 1.00 78.61  ? 375 GLU A O     1 
ATOM 3316 C CB    . GLU D 2 363 ? 169.004 230.498 233.993 1.00 78.61  ? 375 GLU A CB    1 
ATOM 3317 C CG    . GLU D 2 363 ? 167.871 230.005 234.874 1.00 78.61  ? 375 GLU A CG    1 
ATOM 3318 C CD    . GLU D 2 363 ? 166.662 229.567 234.071 1.00 78.61  ? 375 GLU A CD    1 
ATOM 3319 O OE1   . GLU D 2 363 ? 166.323 230.252 233.084 1.00 78.61  ? 375 GLU A OE1   1 
ATOM 3320 O OE2   . GLU D 2 363 ? 166.050 228.539 234.428 1.00 78.61  ? 375 GLU A OE2   1 
ATOM 3321 N N     . SER D 2 364 ? 169.832 230.822 231.023 1.00 76.70  ? 376 SER A N     1 
ATOM 3322 C CA    . SER D 2 364 ? 170.554 231.492 229.953 1.00 76.70  ? 376 SER A CA    1 
ATOM 3323 C C     . SER D 2 364 ? 170.494 233.000 230.147 1.00 76.70  ? 376 SER A C     1 
ATOM 3324 O O     . SER D 2 364 ? 169.428 233.557 230.431 1.00 76.70  ? 376 SER A O     1 
ATOM 3325 C CB    . SER D 2 364 ? 169.975 231.122 228.585 1.00 76.70  ? 376 SER A CB    1 
ATOM 3326 O OG    . SER D 2 364 ? 168.642 231.585 228.458 1.00 76.70  ? 376 SER A OG    1 
ATOM 3327 N N     . SER D 2 365 ? 171.641 233.658 229.992 1.00 72.86  ? 377 SER A N     1 
ATOM 3328 C CA    . SER D 2 365 ? 171.737 235.102 230.141 1.00 72.86  ? 377 SER A CA    1 
ATOM 3329 C C     . SER D 2 365 ? 172.562 235.687 229.005 1.00 72.86  ? 377 SER A C     1 
ATOM 3330 O O     . SER D 2 365 ? 173.443 235.026 228.449 1.00 72.86  ? 377 SER A O     1 
ATOM 3331 C CB    . SER D 2 365 ? 172.365 235.487 231.487 1.00 72.86  ? 377 SER A CB    1 
ATOM 3332 O OG    . SER D 2 365 ? 173.779 235.455 231.416 1.00 72.86  ? 377 SER A OG    1 
ATOM 3333 N N     . THR D 2 366 ? 172.263 236.937 228.664 1.00 69.94  ? 378 THR A N     1 
ATOM 3334 C CA    . THR D 2 366 ? 173.020 237.635 227.636 1.00 69.94  ? 378 THR A CA    1 
ATOM 3335 C C     . THR D 2 366 ? 174.384 238.053 228.170 1.00 69.94  ? 378 THR A C     1 
ATOM 3336 O O     . THR D 2 366 ? 174.517 238.469 229.324 1.00 69.94  ? 378 THR A O     1 
ATOM 3337 C CB    . THR D 2 366 ? 172.252 238.863 227.149 1.00 69.94  ? 378 THR A CB    1 
ATOM 3338 O OG1   . THR D 2 366 ? 170.869 238.528 226.979 1.00 69.94  ? 378 THR A OG1   1 
ATOM 3339 C CG2   . THR D 2 366 ? 172.813 239.353 225.823 1.00 69.94  ? 378 THR A CG2   1 
ATOM 3340 N N     . LEU D 2 367 ? 175.403 237.940 227.323 1.00 72.09  ? 379 LEU A N     1 
ATOM 3341 C CA    . LEU D 2 367 ? 176.755 238.348 227.680 1.00 72.09  ? 379 LEU A CA    1 
ATOM 3342 C C     . LEU D 2 367 ? 176.946 239.816 227.321 1.00 72.09  ? 379 LEU A C     1 
ATOM 3343 O O     . LEU D 2 367 ? 176.778 240.204 226.160 1.00 72.09  ? 379 LEU A O     1 
ATOM 3344 C CB    . LEU D 2 367 ? 177.792 237.480 226.968 1.00 72.09  ? 379 LEU A CB    1 
ATOM 3345 C CG    . LEU D 2 367 ? 177.820 236.002 227.354 1.00 72.09  ? 379 LEU A CG    1 
ATOM 3346 C CD1   . LEU D 2 367 ? 178.893 235.269 226.569 1.00 72.09  ? 379 LEU A CD1   1 
ATOM 3347 C CD2   . LEU D 2 367 ? 178.045 235.846 228.848 1.00 72.09  ? 379 LEU A CD2   1 
ATOM 3348 N N     . GLU D 2 368 ? 177.295 240.629 228.318 1.00 78.24  ? 380 GLU A N     1 
ATOM 3349 C CA    . GLU D 2 368 ? 177.496 242.063 228.114 1.00 78.24  ? 380 GLU A CA    1 
ATOM 3350 C C     . GLU D 2 368 ? 178.923 242.295 227.626 1.00 78.24  ? 380 GLU A C     1 
ATOM 3351 O O     . GLU D 2 368 ? 179.812 242.722 228.364 1.00 78.24  ? 380 GLU A O     1 
ATOM 3352 C CB    . GLU D 2 368 ? 177.205 242.833 229.398 1.00 78.24  ? 380 GLU A CB    1 
ATOM 3353 C CG    . GLU D 2 368 ? 176.886 244.338 229.254 1.00 78.24  ? 380 GLU A CG    1 
ATOM 3354 C CD    . GLU D 2 368 ? 175.904 244.720 228.139 1.00 78.24  ? 380 GLU A CD    1 
ATOM 3355 O OE1   . GLU D 2 368 ? 175.649 245.934 227.995 1.00 78.24  ? 380 GLU A OE1   1 
ATOM 3356 O OE2   . GLU D 2 368 ? 175.339 243.849 227.444 1.00 78.24  ? 380 GLU A OE2   1 
ATOM 3357 N N     . LEU D 2 369 ? 179.136 242.006 226.346 1.00 75.90  ? 381 LEU A N     1 
ATOM 3358 C CA    . LEU D 2 369 ? 180.436 242.214 225.711 1.00 75.90  ? 381 LEU A CA    1 
ATOM 3359 C C     . LEU D 2 369 ? 180.524 243.592 225.063 1.00 75.90  ? 381 LEU A C     1 
ATOM 3360 O O     . LEU D 2 369 ? 180.847 243.732 223.885 1.00 75.90  ? 381 LEU A O     1 
ATOM 3361 C CB    . LEU D 2 369 ? 180.698 241.111 224.692 1.00 75.90  ? 381 LEU A CB    1 
ATOM 3362 C CG    . LEU D 2 369 ? 180.626 239.677 225.217 1.00 75.90  ? 381 LEU A CG    1 
ATOM 3363 C CD1   . LEU D 2 369 ? 180.988 238.688 224.124 1.00 75.90  ? 381 LEU A CD1   1 
ATOM 3364 C CD2   . LEU D 2 369 ? 181.530 239.503 226.424 1.00 75.90  ? 381 LEU A CD2   1 
ATOM 3365 N N     . ARG D 2 370 ? 180.231 244.628 225.844 1.00 78.72  ? 382 ARG A N     1 
ATOM 3366 C CA    . ARG D 2 370 ? 180.277 246.008 225.382 1.00 78.72  ? 382 ARG A CA    1 
ATOM 3367 C C     . ARG D 2 370 ? 181.318 246.769 226.187 1.00 78.72  ? 382 ARG A C     1 
ATOM 3368 O O     . ARG D 2 370 ? 181.348 246.672 227.418 1.00 78.72  ? 382 ARG A O     1 
ATOM 3369 C CB    . ARG D 2 370 ? 178.907 246.680 225.508 1.00 78.72  ? 382 ARG A CB    1 
ATOM 3370 C CG    . ARG D 2 370 ? 178.216 246.912 224.179 1.00 78.72  ? 382 ARG A CG    1 
ATOM 3371 C CD    . ARG D 2 370 ? 176.890 247.632 224.352 1.00 78.72  ? 382 ARG A CD    1 
ATOM 3372 N NE    . ARG D 2 370 ? 175.934 246.861 225.138 1.00 78.72  ? 382 ARG A NE    1 
ATOM 3373 C CZ    . ARG D 2 370 ? 175.268 245.809 224.683 1.00 78.72  ? 382 ARG A CZ    1 
ATOM 3374 N NH1   . ARG D 2 370 ? 175.432 245.368 223.447 1.00 78.72  ? 382 ARG A NH1   1 
ATOM 3375 N NH2   . ARG D 2 370 ? 174.410 245.187 225.486 1.00 78.72  ? 382 ARG A NH2   1 
ATOM 3376 N N     . SER D 2 371 ? 182.167 247.521 225.493 1.00 77.88  ? 383 SER A N     1 
ATOM 3377 C CA    . SER D 2 371 ? 183.250 248.269 226.115 1.00 77.88  ? 383 SER A CA    1 
ATOM 3378 C C     . SER D 2 371 ? 183.083 249.749 225.809 1.00 77.88  ? 383 SER A C     1 
ATOM 3379 O O     . SER D 2 371 ? 182.768 250.121 224.674 1.00 77.88  ? 383 SER A O     1 
ATOM 3380 C CB    . SER D 2 371 ? 184.611 247.775 225.621 1.00 77.88  ? 383 SER A CB    1 
ATOM 3381 O OG    . SER D 2 371 ? 184.565 247.475 224.238 1.00 77.88  ? 383 SER A OG    1 
ATOM 3382 N N     . ARG D 2 372 ? 183.290 250.588 226.827 1.00 80.84  ? 384 ARG A N     1 
ATOM 3383 C CA    . ARG D 2 372 ? 183.183 252.030 226.632 1.00 80.84  ? 384 ARG A CA    1 
ATOM 3384 C C     . ARG D 2 372 ? 184.253 252.535 225.672 1.00 80.84  ? 384 ARG A C     1 
ATOM 3385 O O     . ARG D 2 372 ? 183.971 253.353 224.789 1.00 80.84  ? 384 ARG A O     1 
ATOM 3386 C CB    . ARG D 2 372 ? 183.284 252.744 227.980 1.00 80.84  ? 384 ARG A CB    1 
ATOM 3387 C CG    . ARG D 2 372 ? 183.588 254.233 227.898 1.00 80.84  ? 384 ARG A CG    1 
ATOM 3388 C CD    . ARG D 2 372 ? 182.463 254.996 227.213 1.00 80.84  ? 384 ARG A CD    1 
ATOM 3389 N NE    . ARG D 2 372 ? 182.878 256.329 226.791 1.00 80.84  ? 384 ARG A NE    1 
ATOM 3390 C CZ    . ARG D 2 372 ? 183.529 256.593 225.667 1.00 80.84  ? 384 ARG A CZ    1 
ATOM 3391 N NH1   . ARG D 2 372 ? 183.856 255.636 224.815 1.00 80.84  ? 384 ARG A NH1   1 
ATOM 3392 N NH2   . ARG D 2 372 ? 183.858 257.852 225.388 1.00 80.84  ? 384 ARG A NH2   1 
ATOM 3393 N N     . TYR D 2 373 ? 185.482 252.050 225.820 1.00 80.45  ? 385 TYR A N     1 
ATOM 3394 C CA    . TYR D 2 373 ? 186.602 252.470 224.995 1.00 80.45  ? 385 TYR A CA    1 
ATOM 3395 C C     . TYR D 2 373 ? 187.146 251.285 224.209 1.00 80.45  ? 385 TYR A C     1 
ATOM 3396 O O     . TYR D 2 373 ? 186.893 250.123 224.537 1.00 80.45  ? 385 TYR A O     1 
ATOM 3397 C CB    . TYR D 2 373 ? 187.720 253.082 225.848 1.00 80.45  ? 385 TYR A CB    1 
ATOM 3398 C CG    . TYR D 2 373 ? 187.552 254.558 226.119 1.00 80.45  ? 385 TYR A CG    1 
ATOM 3399 C CD1   . TYR D 2 373 ? 187.090 255.416 225.132 1.00 80.45  ? 385 TYR A CD1   1 
ATOM 3400 C CD2   . TYR D 2 373 ? 187.855 255.092 227.363 1.00 80.45  ? 385 TYR A CD2   1 
ATOM 3401 C CE1   . TYR D 2 373 ? 186.936 256.766 225.376 1.00 80.45  ? 385 TYR A CE1   1 
ATOM 3402 C CE2   . TYR D 2 373 ? 187.704 256.440 227.617 1.00 80.45  ? 385 TYR A CE2   1 
ATOM 3403 C CZ    . TYR D 2 373 ? 187.244 257.272 226.621 1.00 80.45  ? 385 TYR A CZ    1 
ATOM 3404 O OH    . TYR D 2 373 ? 187.091 258.617 226.869 1.00 80.45  ? 385 TYR A OH    1 
ATOM 3405 N N     . TRP D 2 374 ? 187.899 251.597 223.157 1.00 76.70  ? 386 TRP A N     1 
ATOM 3406 C CA    . TRP D 2 374 ? 188.594 250.587 222.374 1.00 76.70  ? 386 TRP A CA    1 
ATOM 3407 C C     . TRP D 2 374 ? 190.044 251.011 222.200 1.00 76.70  ? 386 TRP A C     1 
ATOM 3408 O O     . TRP D 2 374 ? 190.350 252.201 222.088 1.00 76.70  ? 386 TRP A O     1 
ATOM 3409 C CB    . TRP D 2 374 ? 187.935 250.369 221.004 1.00 76.70  ? 386 TRP A CB    1 
ATOM 3410 C CG    . TRP D 2 374 ? 188.286 251.414 219.993 1.00 76.70  ? 386 TRP A CG    1 
ATOM 3411 C CD1   . TRP D 2 374 ? 187.646 252.598 219.785 1.00 76.70  ? 386 TRP A CD1   1 
ATOM 3412 C CD2   . TRP D 2 374 ? 189.359 251.366 219.046 1.00 76.70  ? 386 TRP A CD2   1 
ATOM 3413 N NE1   . TRP D 2 374 ? 188.256 253.295 218.770 1.00 76.70  ? 386 TRP A NE1   1 
ATOM 3414 C CE2   . TRP D 2 374 ? 189.311 252.559 218.300 1.00 76.70  ? 386 TRP A CE2   1 
ATOM 3415 C CE3   . TRP D 2 374 ? 190.358 250.432 218.759 1.00 76.70  ? 386 TRP A CE3   1 
ATOM 3416 C CZ2   . TRP D 2 374 ? 190.220 252.841 217.284 1.00 76.70  ? 386 TRP A CZ2   1 
ATOM 3417 C CZ3   . TRP D 2 374 ? 191.258 250.714 217.751 1.00 76.70  ? 386 TRP A CZ3   1 
ATOM 3418 C CH2   . TRP D 2 374 ? 191.184 251.908 217.026 1.00 76.70  ? 386 TRP A CH2   1 
ATOM 3419 N N     . ALA D 2 375 ? 190.936 250.025 222.185 1.00 72.52  ? 387 ALA A N     1 
ATOM 3420 C CA    . ALA D 2 375 ? 192.362 250.282 222.066 1.00 72.52  ? 387 ALA A CA    1 
ATOM 3421 C C     . ALA D 2 375 ? 192.981 249.272 221.113 1.00 72.52  ? 387 ALA A C     1 
ATOM 3422 O O     . ALA D 2 375 ? 192.450 248.180 220.898 1.00 72.52  ? 387 ALA A O     1 
ATOM 3423 C CB    . ALA D 2 375 ? 193.063 250.227 223.429 1.00 72.52  ? 387 ALA A CB    1 
ATOM 3424 N N     . ILE D 2 376 ? 194.114 249.655 220.540 1.00 69.51  ? 388 ILE A N     1 
ATOM 3425 C CA    . ILE D 2 376 ? 194.849 248.800 219.617 1.00 69.51  ? 388 ILE A CA    1 
ATOM 3426 C C     . ILE D 2 376 ? 195.780 247.902 220.416 1.00 69.51  ? 388 ILE A C     1 
ATOM 3427 O O     . ILE D 2 376 ? 196.563 248.381 221.245 1.00 69.51  ? 388 ILE A O     1 
ATOM 3428 C CB    . ILE D 2 376 ? 195.630 249.639 218.593 1.00 69.51  ? 388 ILE A CB    1 
ATOM 3429 C CG1   . ILE D 2 376 ? 194.678 250.198 217.536 1.00 69.51  ? 388 ILE A CG1   1 
ATOM 3430 C CG2   . ILE D 2 376 ? 196.724 248.808 217.941 1.00 69.51  ? 388 ILE A CG2   1 
ATOM 3431 C CD1   . ILE D 2 376 ? 195.134 251.499 216.927 1.00 69.51  ? 388 ILE A CD1   1 
ATOM 3432 N N     . ARG D 2 377 ? 195.688 246.598 220.178 1.00 69.44  ? 389 ARG A N     1 
ATOM 3433 C CA    . ARG D 2 377 ? 196.550 245.652 220.869 1.00 69.44  ? 389 ARG A CA    1 
ATOM 3434 C C     . ARG D 2 377 ? 197.993 245.810 220.409 1.00 69.44  ? 389 ARG A C     1 
ATOM 3435 O O     . ARG D 2 377 ? 198.269 245.987 219.220 1.00 69.44  ? 389 ARG A O     1 
ATOM 3436 C CB    . ARG D 2 377 ? 196.073 244.222 220.626 1.00 69.44  ? 389 ARG A CB    1 
ATOM 3437 C CG    . ARG D 2 377 ? 195.076 243.731 221.654 1.00 69.44  ? 389 ARG A CG    1 
ATOM 3438 C CD    . ARG D 2 377 ? 193.941 242.976 220.999 1.00 69.44  ? 389 ARG A CD    1 
ATOM 3439 N NE    . ARG D 2 377 ? 193.314 243.751 219.935 1.00 69.44  ? 389 ARG A NE    1 
ATOM 3440 C CZ    . ARG D 2 377 ? 192.504 244.782 220.135 1.00 69.44  ? 389 ARG A CZ    1 
ATOM 3441 N NH1   . ARG D 2 377 ? 192.193 245.190 221.354 1.00 69.44  ? 389 ARG A NH1   1 
ATOM 3442 N NH2   . ARG D 2 377 ? 191.991 245.417 219.086 1.00 69.44  ? 389 ARG A NH2   1 
ATOM 3443 N N     . THR D 2 378 ? 198.916 245.742 221.362 1.00 77.00  ? 390 THR A N     1 
ATOM 3444 C CA    . THR D 2 378 ? 200.337 245.885 221.092 1.00 77.00  ? 390 THR A CA    1 
ATOM 3445 C C     . THR D 2 378 ? 201.041 244.553 221.311 1.00 77.00  ? 390 THR A C     1 
ATOM 3446 O O     . THR D 2 378 ? 200.737 243.826 222.261 1.00 77.00  ? 390 THR A O     1 
ATOM 3447 C CB    . THR D 2 378 ? 200.965 246.966 221.980 1.00 77.00  ? 390 THR A CB    1 
ATOM 3448 O OG1   . THR D 2 378 ? 202.385 246.984 221.787 1.00 77.00  ? 390 THR A OG1   1 
ATOM 3449 C CG2   . THR D 2 378 ? 200.656 246.713 223.449 1.00 77.00  ? 390 THR A CG2   1 
ATOM 3450 N N     . ARG D 2 379 ? 201.972 244.233 220.417 1.00 80.19  ? 391 ARG A N     1 
ATOM 3451 C CA    . ARG D 2 379 ? 202.749 243.006 220.503 1.00 80.19  ? 391 ARG A CA    1 
ATOM 3452 C C     . ARG D 2 379 ? 204.085 243.212 221.202 1.00 80.19  ? 391 ARG A C     1 
ATOM 3453 O O     . ARG D 2 379 ? 204.905 242.290 221.235 1.00 80.19  ? 391 ARG A O     1 
ATOM 3454 C CB    . ARG D 2 379 ? 202.964 242.423 219.104 1.00 80.19  ? 391 ARG A CB    1 
ATOM 3455 C CG    . ARG D 2 379 ? 203.923 243.220 218.239 1.00 80.19  ? 391 ARG A CG    1 
ATOM 3456 C CD    . ARG D 2 379 ? 204.259 242.474 216.957 1.00 80.19  ? 391 ARG A CD    1 
ATOM 3457 N NE    . ARG D 2 379 ? 203.099 242.304 216.090 1.00 80.19  ? 391 ARG A NE    1 
ATOM 3458 C CZ    . ARG D 2 379 ? 203.013 241.409 215.115 1.00 80.19  ? 391 ARG A CZ    1 
ATOM 3459 N NH1   . ARG D 2 379 ? 204.010 240.583 214.843 1.00 80.19  ? 391 ARG A NH1   1 
ATOM 3460 N NH2   . ARG D 2 379 ? 201.898 241.342 214.393 1.00 80.19  ? 391 ARG A NH2   1 
ATOM 3461 N N     . SER D 2 380 ? 204.320 244.397 221.762 1.00 86.10  ? 392 SER A N     1 
ATOM 3462 C CA    . SER D 2 380 ? 205.579 244.701 222.430 1.00 86.10  ? 392 SER A CA    1 
ATOM 3463 C C     . SER D 2 380 ? 205.608 244.136 223.843 1.00 86.10  ? 392 SER A C     1 
ATOM 3464 O O     . SER D 2 380 ? 204.697 243.406 224.248 1.00 86.10  ? 392 SER A O     1 
ATOM 3465 C CB    . SER D 2 380 ? 205.814 246.212 222.465 1.00 86.10  ? 392 SER A CB    1 
ATOM 3466 O OG    . SER D 2 380 ? 207.189 246.510 222.623 1.00 86.10  ? 392 SER A OG    1 
ATOM 3467 N N     . GLY D 2 381 ? 206.650 244.471 224.598 1.00 94.96  ? 393 GLY A N     1 
ATOM 3468 C CA    . GLY D 2 381 ? 206.782 244.004 225.963 1.00 94.96  ? 393 GLY A CA    1 
ATOM 3469 C C     . GLY D 2 381 ? 206.855 245.137 226.964 1.00 94.96  ? 393 GLY A C     1 
ATOM 3470 O O     . GLY D 2 381 ? 206.582 244.945 228.153 1.00 94.96  ? 393 GLY A O     1 
ATOM 3471 N N     . GLY D 2 382 ? 207.226 246.318 226.497 1.00 94.07  ? 394 GLY A N     1 
ATOM 3472 C CA    . GLY D 2 382 ? 207.329 247.496 227.340 1.00 94.07  ? 394 GLY A CA    1 
ATOM 3473 C C     . GLY D 2 382 ? 208.723 248.085 227.257 1.00 94.07  ? 394 GLY A C     1 
ATOM 3474 O O     . GLY D 2 382 ? 209.686 247.423 226.867 1.00 94.07  ? 394 GLY A O     1 
ATOM 3475 N N     . ASN D 2 383 ? 208.836 249.358 227.627 1.00 99.60  ? 395 ASN A N     1 
ATOM 3476 C CA    . ASN D 2 383 ? 210.128 250.029 227.608 1.00 99.60  ? 395 ASN A CA    1 
ATOM 3477 C C     . ASN D 2 383 ? 211.052 249.431 228.663 1.00 99.60  ? 395 ASN A C     1 
ATOM 3478 O O     . ASN D 2 383 ? 210.652 249.222 229.812 1.00 99.60  ? 395 ASN A O     1 
ATOM 3479 C CB    . ASN D 2 383 ? 209.953 251.529 227.841 1.00 99.60  ? 395 ASN A CB    1 
ATOM 3480 C CG    . ASN D 2 383 ? 209.229 251.841 229.137 1.00 99.60  ? 395 ASN A CG    1 
ATOM 3481 O OD1   . ASN D 2 383 ? 208.558 250.984 229.711 1.00 99.60  ? 395 ASN A OD1   1 
ATOM 3482 N ND2   . ASN D 2 383 ? 209.363 253.076 229.605 1.00 99.60  ? 395 ASN A ND2   1 
ATOM 3483 N N     . THR D 2 384 ? 212.290 249.144 228.265 1.00 105.93 ? 396 THR A N     1 
ATOM 3484 C CA    . THR D 2 384 ? 213.279 248.568 229.167 1.00 105.93 ? 396 THR A CA    1 
ATOM 3485 C C     . THR D 2 384 ? 214.608 249.306 229.188 1.00 105.93 ? 396 THR A C     1 
ATOM 3486 O O     . THR D 2 384 ? 215.291 249.254 230.218 1.00 105.93 ? 396 THR A O     1 
ATOM 3487 C CB    . THR D 2 384 ? 213.546 247.098 228.809 1.00 105.93 ? 396 THR A CB    1 
ATOM 3488 O OG1   . THR D 2 384 ? 214.098 247.023 227.490 1.00 105.93 ? 396 THR A OG1   1 
ATOM 3489 C CG2   . THR D 2 384 ? 212.262 246.281 228.870 1.00 105.93 ? 396 THR A CG2   1 
ATOM 3490 N N     . ASN D 2 385 ? 214.980 249.997 228.107 1.00 108.91 ? 397 ASN A N     1 
ATOM 3491 C CA    . ASN D 2 385 ? 216.240 250.742 227.938 1.00 108.91 ? 397 ASN A CA    1 
ATOM 3492 C C     . ASN D 2 385 ? 217.347 250.438 228.948 1.00 108.91 ? 397 ASN A C     1 
ATOM 3493 O O     . ASN D 2 385 ? 218.273 251.230 229.125 1.00 108.91 ? 397 ASN A O     1 
ATOM 3494 C CB    . ASN D 2 385 ? 215.956 252.250 227.953 1.00 108.91 ? 397 ASN A CB    1 
ATOM 3495 C CG    . ASN D 2 385 ? 215.560 252.766 229.325 1.00 108.91 ? 397 ASN A CG    1 
ATOM 3496 O OD1   . ASN D 2 385 ? 214.994 252.041 230.140 1.00 108.91 ? 397 ASN A OD1   1 
ATOM 3497 N ND2   . ASN D 2 385 ? 215.861 254.033 229.584 1.00 108.91 ? 397 ASN A ND2   1 
ATOM 3498 N N     . ASP D 2 427 ? 229.592 238.545 234.099 1.00 132.50 ? 439 ASP A N     1 
ATOM 3499 C CA    . ASP D 2 427 ? 229.097 237.945 232.867 1.00 132.50 ? 439 ASP A CA    1 
ATOM 3500 C C     . ASP D 2 427 ? 227.765 238.556 232.452 1.00 132.50 ? 439 ASP A C     1 
ATOM 3501 O O     . ASP D 2 427 ? 227.315 239.544 233.033 1.00 132.50 ? 439 ASP A O     1 
ATOM 3502 C CB    . ASP D 2 427 ? 228.949 236.431 233.028 1.00 132.50 ? 439 ASP A CB    1 
ATOM 3503 C CG    . ASP D 2 427 ? 230.284 235.719 233.096 1.00 132.50 ? 439 ASP A CG    1 
ATOM 3504 O OD1   . ASP D 2 427 ? 231.307 236.336 232.731 1.00 132.50 ? 439 ASP A OD1   1 
ATOM 3505 O OD2   . ASP D 2 427 ? 230.312 234.543 233.515 1.00 132.50 ? 439 ASP A OD2   1 
ATOM 3506 N N     . MET D 2 428 ? 227.138 237.957 231.438 1.00 123.42 ? 440 MET A N     1 
ATOM 3507 C CA    . MET D 2 428 ? 225.853 238.456 230.960 1.00 123.42 ? 440 MET A CA    1 
ATOM 3508 C C     . MET D 2 428 ? 224.747 238.256 231.988 1.00 123.42 ? 440 MET A C     1 
ATOM 3509 O O     . MET D 2 428 ? 223.758 238.997 231.985 1.00 123.42 ? 440 MET A O     1 
ATOM 3510 C CB    . MET D 2 428 ? 225.497 237.783 229.633 1.00 123.42 ? 440 MET A CB    1 
ATOM 3511 C CG    . MET D 2 428 ? 224.915 236.389 229.768 1.00 123.42 ? 440 MET A CG    1 
ATOM 3512 S SD    . MET D 2 428 ? 225.998 235.313 230.727 1.00 123.42 ? 440 MET A SD    1 
ATOM 3513 C CE    . MET D 2 428 ? 227.343 235.064 229.574 1.00 123.42 ? 440 MET A CE    1 
ATOM 3514 N N     . ARG D 2 429 ? 224.888 237.263 232.870 1.00 121.49 ? 441 ARG A N     1 
ATOM 3515 C CA    . ARG D 2 429 ? 223.915 237.090 233.944 1.00 121.49 ? 441 ARG A CA    1 
ATOM 3516 C C     . ARG D 2 429 ? 223.914 238.294 234.876 1.00 121.49 ? 441 ARG A C     1 
ATOM 3517 O O     . ARG D 2 429 ? 222.852 238.801 235.254 1.00 121.49 ? 441 ARG A O     1 
ATOM 3518 C CB    . ARG D 2 429 ? 224.207 235.810 234.726 1.00 121.49 ? 441 ARG A CB    1 
ATOM 3519 C CG    . ARG D 2 429 ? 224.586 234.622 233.868 1.00 121.49 ? 441 ARG A CG    1 
ATOM 3520 C CD    . ARG D 2 429 ? 224.388 233.331 234.635 1.00 121.49 ? 441 ARG A CD    1 
ATOM 3521 N NE    . ARG D 2 429 ? 223.032 232.819 234.482 1.00 121.49 ? 441 ARG A NE    1 
ATOM 3522 C CZ    . ARG D 2 429 ? 222.572 231.729 235.080 1.00 121.49 ? 441 ARG A CZ    1 
ATOM 3523 N NH1   . ARG D 2 429 ? 223.336 231.007 235.884 1.00 121.49 ? 441 ARG A NH1   1 
ATOM 3524 N NH2   . ARG D 2 429 ? 221.316 231.351 234.864 1.00 121.49 ? 441 ARG A NH2   1 
ATOM 3525 N N     . THR D 2 430 ? 225.103 238.769 235.253 1.00 123.00 ? 442 THR A N     1 
ATOM 3526 C CA    . THR D 2 430 ? 225.193 239.954 236.099 1.00 123.00 ? 442 THR A CA    1 
ATOM 3527 C C     . THR D 2 430 ? 224.647 241.181 235.382 1.00 123.00 ? 442 THR A C     1 
ATOM 3528 O O     . THR D 2 430 ? 223.988 242.028 235.997 1.00 123.00 ? 442 THR A O     1 
ATOM 3529 C CB    . THR D 2 430 ? 226.641 240.187 236.529 1.00 123.00 ? 442 THR A CB    1 
ATOM 3530 O OG1   . THR D 2 430 ? 227.104 239.061 237.283 1.00 123.00 ? 442 THR A OG1   1 
ATOM 3531 C CG2   . THR D 2 430 ? 226.747 241.442 237.382 1.00 123.00 ? 442 THR A CG2   1 
ATOM 3532 N N     . GLU D 2 431 ? 224.916 241.295 234.080 1.00 121.68 ? 443 GLU A N     1 
ATOM 3533 C CA    . GLU D 2 431 ? 224.371 242.405 233.306 1.00 121.68 ? 443 GLU A CA    1 
ATOM 3534 C C     . GLU D 2 431 ? 222.849 242.359 233.281 1.00 121.68 ? 443 GLU A C     1 
ATOM 3535 O O     . GLU D 2 431 ? 222.186 243.395 233.414 1.00 121.68 ? 443 GLU A O     1 
ATOM 3536 C CB    . GLU D 2 431 ? 224.934 242.376 231.884 1.00 121.68 ? 443 GLU A CB    1 
ATOM 3537 C CG    . GLU D 2 431 ? 224.673 243.624 231.034 1.00 121.68 ? 443 GLU A CG    1 
ATOM 3538 C CD    . GLU D 2 431 ? 224.951 244.936 231.756 1.00 121.68 ? 443 GLU A CD    1 
ATOM 3539 O OE1   . GLU D 2 431 ? 225.952 245.596 231.408 1.00 121.68 ? 443 GLU A OE1   1 
ATOM 3540 O OE2   . GLU D 2 431 ? 224.155 245.337 232.632 1.00 121.68 ? 443 GLU A OE2   1 
ATOM 3541 N N     . ILE D 2 432 ? 222.277 241.165 233.110 1.00 117.41 ? 444 ILE A N     1 
ATOM 3542 C CA    . ILE D 2 432 ? 220.823 241.025 233.121 1.00 117.41 ? 444 ILE A CA    1 
ATOM 3543 C C     . ILE D 2 432 ? 220.264 241.376 234.494 1.00 117.41 ? 444 ILE A C     1 
ATOM 3544 O O     . ILE D 2 432 ? 219.237 242.057 234.608 1.00 117.41 ? 444 ILE A O     1 
ATOM 3545 C CB    . ILE D 2 432 ? 220.425 239.602 232.688 1.00 117.41 ? 444 ILE A CB    1 
ATOM 3546 C CG1   . ILE D 2 432 ? 220.673 239.416 231.192 1.00 117.41 ? 444 ILE A CG1   1 
ATOM 3547 C CG2   . ILE D 2 432 ? 218.967 239.332 233.000 1.00 117.41 ? 444 ILE A CG2   1 
ATOM 3548 C CD1   . ILE D 2 432 ? 220.546 237.985 230.731 1.00 117.41 ? 444 ILE A CD1   1 
ATOM 3549 N N     . ILE D 2 433 ? 220.932 240.922 235.558 1.00 118.25 ? 445 ILE A N     1 
ATOM 3550 C CA    . ILE D 2 433 ? 220.492 241.246 236.914 1.00 118.25 ? 445 ILE A CA    1 
ATOM 3551 C C     . ILE D 2 433 ? 220.545 242.749 237.149 1.00 118.25 ? 445 ILE A C     1 
ATOM 3552 O O     . ILE D 2 433 ? 219.636 243.330 237.757 1.00 118.25 ? 445 ILE A O     1 
ATOM 3553 C CB    . ILE D 2 433 ? 221.336 240.479 237.950 1.00 118.25 ? 445 ILE A CB    1 
ATOM 3554 C CG1   . ILE D 2 433 ? 221.082 238.972 237.838 1.00 118.25 ? 445 ILE A CG1   1 
ATOM 3555 C CG2   . ILE D 2 433 ? 221.056 240.987 239.360 1.00 118.25 ? 445 ILE A CG2   1 
ATOM 3556 C CD1   . ILE D 2 433 ? 220.007 238.453 238.771 1.00 118.25 ? 445 ILE A CD1   1 
ATOM 3557 N N     . ARG D 2 434 ? 221.605 243.404 236.670 1.00 121.43 ? 446 ARG A N     1 
ATOM 3558 C CA    . ARG D 2 434 ? 221.735 244.844 236.864 1.00 121.43 ? 446 ARG A CA    1 
ATOM 3559 C C     . ARG D 2 434 ? 220.606 245.602 236.175 1.00 121.43 ? 446 ARG A C     1 
ATOM 3560 O O     . ARG D 2 434 ? 220.197 246.674 236.635 1.00 121.43 ? 446 ARG A O     1 
ATOM 3561 C CB    . ARG D 2 434 ? 223.094 245.319 236.350 1.00 121.43 ? 446 ARG A CB    1 
ATOM 3562 C CG    . ARG D 2 434 ? 223.606 246.579 237.025 1.00 121.43 ? 446 ARG A CG    1 
ATOM 3563 C CD    . ARG D 2 434 ? 224.958 246.996 236.460 1.00 121.43 ? 446 ARG A CD    1 
ATOM 3564 N NE    . ARG D 2 434 ? 224.963 247.071 235.003 1.00 121.43 ? 446 ARG A NE    1 
ATOM 3565 C CZ    . ARG D 2 434 ? 224.243 247.923 234.283 1.00 121.43 ? 446 ARG A CZ    1 
ATOM 3566 N NH1   . ARG D 2 434 ? 223.465 248.830 234.852 1.00 121.43 ? 446 ARG A NH1   1 
ATOM 3567 N NH2   . ARG D 2 434 ? 224.316 247.871 232.956 1.00 121.43 ? 446 ARG A NH2   1 
ATOM 3568 N N     . LEU D 2 435 ? 220.093 245.062 235.067 1.00 116.55 ? 447 LEU A N     1 
ATOM 3569 C CA    . LEU D 2 435 ? 218.991 245.716 234.367 1.00 116.55 ? 447 LEU A CA    1 
ATOM 3570 C C     . LEU D 2 435 ? 217.719 245.722 235.208 1.00 116.55 ? 447 LEU A C     1 
ATOM 3571 O O     . LEU D 2 435 ? 216.971 246.707 235.205 1.00 116.55 ? 447 LEU A O     1 
ATOM 3572 C CB    . LEU D 2 435 ? 218.746 245.039 233.019 1.00 116.55 ? 447 LEU A CB    1 
ATOM 3573 C CG    . LEU D 2 435 ? 219.409 245.677 231.792 1.00 116.55 ? 447 LEU A CG    1 
ATOM 3574 C CD1   . LEU D 2 435 ? 218.638 246.914 231.358 1.00 116.55 ? 447 LEU A CD1   1 
ATOM 3575 C CD2   . LEU D 2 435 ? 220.867 246.022 232.053 1.00 116.55 ? 447 LEU A CD2   1 
ATOM 3576 N N     . MET D 2 436 ? 217.448 244.628 235.928 1.00 117.94 ? 448 MET A N     1 
ATOM 3577 C CA    . MET D 2 436 ? 216.264 244.589 236.782 1.00 117.94 ? 448 MET A CA    1 
ATOM 3578 C C     . MET D 2 436 ? 216.349 245.624 237.894 1.00 117.94 ? 448 MET A C     1 
ATOM 3579 O O     . MET D 2 436 ? 215.324 246.154 238.338 1.00 117.94 ? 448 MET A O     1 
ATOM 3580 C CB    . MET D 2 436 ? 216.073 243.194 237.377 1.00 117.94 ? 448 MET A CB    1 
ATOM 3581 C CG    . MET D 2 436 ? 216.294 242.036 236.421 1.00 117.94 ? 448 MET A CG    1 
ATOM 3582 S SD    . MET D 2 436 ? 216.994 240.613 237.277 1.00 117.94 ? 448 MET A SD    1 
ATOM 3583 C CE    . MET D 2 436 ? 216.985 239.391 235.972 1.00 117.94 ? 448 MET A CE    1 
ATOM 3584 N N     . GLU D 2 437 ? 217.564 245.917 238.361 1.00 119.80 ? 449 GLU A N     1 
ATOM 3585 C CA    . GLU D 2 437 ? 217.734 246.856 239.464 1.00 119.80 ? 449 GLU A CA    1 
ATOM 3586 C C     . GLU D 2 437 ? 217.248 248.251 239.079 1.00 119.80 ? 449 GLU A C     1 
ATOM 3587 O O     . GLU D 2 437 ? 216.671 248.966 239.905 1.00 119.80 ? 449 GLU A O     1 
ATOM 3588 C CB    . GLU D 2 437 ? 219.204 246.890 239.889 1.00 119.80 ? 449 GLU A CB    1 
ATOM 3589 C CG    . GLU D 2 437 ? 219.569 247.969 240.902 1.00 119.80 ? 449 GLU A CG    1 
ATOM 3590 C CD    . GLU D 2 437 ? 218.837 247.812 242.225 1.00 119.80 ? 449 GLU A CD    1 
ATOM 3591 O OE1   . GLU D 2 437 ? 219.422 247.228 243.163 1.00 119.80 ? 449 GLU A OE1   1 
ATOM 3592 O OE2   . GLU D 2 437 ? 217.677 248.261 242.330 1.00 119.80 ? 449 GLU A OE2   1 
ATOM 3593 N N     . SER D 2 438 ? 217.457 248.646 237.821 1.00 114.77 ? 450 SER A N     1 
ATOM 3594 C CA    . SER D 2 438 ? 217.154 250.012 237.401 1.00 114.77 ? 450 SER A CA    1 
ATOM 3595 C C     . SER D 2 438 ? 215.657 250.304 237.386 1.00 114.77 ? 450 SER A C     1 
ATOM 3596 O O     . SER D 2 438 ? 215.252 251.443 237.644 1.00 114.77 ? 450 SER A O     1 
ATOM 3597 C CB    . SER D 2 438 ? 217.740 250.271 236.014 1.00 114.77 ? 450 SER A CB    1 
ATOM 3598 O OG    . SER D 2 438 ? 216.914 249.711 235.006 1.00 114.77 ? 450 SER A OG    1 
ATOM 3599 N N     . ALA D 2 439 ? 214.828 249.308 237.086 1.00 111.34 ? 451 ALA A N     1 
ATOM 3600 C CA    . ALA D 2 439 ? 213.403 249.532 236.887 1.00 111.34 ? 451 ALA A CA    1 
ATOM 3601 C C     . ALA D 2 439 ? 212.738 250.070 238.155 1.00 111.34 ? 451 ALA A C     1 
ATOM 3602 O O     . ALA D 2 439 ? 212.904 249.534 239.255 1.00 111.34 ? 451 ALA A O     1 
ATOM 3603 C CB    . ALA D 2 439 ? 212.725 248.232 236.463 1.00 111.34 ? 451 ALA A CB    1 
ATOM 3604 N N     . ARG D 2 440 ? 211.953 251.134 237.985 1.00 113.20 ? 452 ARG A N     1 
ATOM 3605 C CA    . ARG D 2 440 ? 211.229 251.805 239.061 1.00 113.20 ? 452 ARG A CA    1 
ATOM 3606 C C     . ARG D 2 440 ? 209.742 251.822 238.735 1.00 113.20 ? 452 ARG A C     1 
ATOM 3607 O O     . ARG D 2 440 ? 209.367 251.844 237.557 1.00 113.20 ? 452 ARG A O     1 
ATOM 3608 C CB    . ARG D 2 440 ? 211.740 253.246 239.262 1.00 113.20 ? 452 ARG A CB    1 
ATOM 3609 C CG    . ARG D 2 440 ? 213.250 253.369 239.541 1.00 113.20 ? 452 ARG A CG    1 
ATOM 3610 C CD    . ARG D 2 440 ? 213.582 253.053 240.998 1.00 113.20 ? 452 ARG A CD    1 
ATOM 3611 N NE    . ARG D 2 440 ? 213.646 251.623 241.262 1.00 113.20 ? 452 ARG A NE    1 
ATOM 3612 C CZ    . ARG D 2 440 ? 214.736 250.874 241.177 1.00 113.20 ? 452 ARG A CZ    1 
ATOM 3613 N NH1   . ARG D 2 440 ? 215.910 251.388 240.850 1.00 113.20 ? 452 ARG A NH1   1 
ATOM 3614 N NH2   . ARG D 2 440 ? 214.642 249.570 241.421 1.00 113.20 ? 452 ARG A NH2   1 
ATOM 3615 N N     . PRO D 2 441 ? 208.822 251.731 239.727 1.00 110.03 ? 453 PRO A N     1 
ATOM 3616 C CA    . PRO D 2 441 ? 207.388 251.617 239.420 1.00 110.03 ? 453 PRO A CA    1 
ATOM 3617 C C     . PRO D 2 441 ? 206.792 252.889 238.798 1.00 110.03 ? 453 PRO A C     1 
ATOM 3618 O O     . PRO D 2 441 ? 205.686 253.246 239.161 1.00 110.03 ? 453 PRO A O     1 
ATOM 3619 C CB    . PRO D 2 441 ? 206.742 251.362 240.790 1.00 110.03 ? 453 PRO A CB    1 
ATOM 3620 C CG    . PRO D 2 441 ? 207.697 251.998 241.769 1.00 110.03 ? 453 PRO A CG    1 
ATOM 3621 C CD    . PRO D 2 441 ? 209.067 251.739 241.180 1.00 110.03 ? 453 PRO A CD    1 
ATOM 3622 N N     . GLU D 2 442 ? 207.526 253.532 237.885 1.00 107.45 ? 454 GLU A N     1 
ATOM 3623 C CA    . GLU D 2 442 ? 207.009 254.732 237.240 1.00 107.45 ? 454 GLU A CA    1 
ATOM 3624 C C     . GLU D 2 442 ? 207.321 254.840 235.757 1.00 107.45 ? 454 GLU A C     1 
ATOM 3625 O O     . GLU D 2 442 ? 206.900 255.824 235.136 1.00 107.45 ? 454 GLU A O     1 
ATOM 3626 C CB    . GLU D 2 442 ? 207.531 256.005 237.933 1.00 107.45 ? 454 GLU A CB    1 
ATOM 3627 C CG    . GLU D 2 442 ? 207.156 256.174 239.411 1.00 107.45 ? 454 GLU A CG    1 
ATOM 3628 C CD    . GLU D 2 442 ? 207.971 255.321 240.360 1.00 107.45 ? 454 GLU A CD    1 
ATOM 3629 O OE1   . GLU D 2 442 ? 209.017 254.778 239.939 1.00 107.45 ? 454 GLU A OE1   1 
ATOM 3630 O OE2   . GLU D 2 442 ? 207.555 255.187 241.536 1.00 107.45 ? 454 GLU A OE2   1 
ATOM 3631 N N     . ASP D 2 443 ? 208.061 253.900 235.172 1.00 100.99 ? 455 ASP A N     1 
ATOM 3632 C CA    . ASP D 2 443 ? 208.416 254.045 233.766 1.00 100.99 ? 455 ASP A CA    1 
ATOM 3633 C C     . ASP D 2 443 ? 207.163 253.945 232.908 1.00 100.99 ? 455 ASP A C     1 
ATOM 3634 O O     . ASP D 2 443 ? 206.360 253.019 233.056 1.00 100.99 ? 455 ASP A O     1 
ATOM 3635 C CB    . ASP D 2 443 ? 209.442 252.990 233.348 1.00 100.99 ? 455 ASP A CB    1 
ATOM 3636 C CG    . ASP D 2 443 ? 208.947 251.581 233.566 1.00 100.99 ? 455 ASP A CG    1 
ATOM 3637 O OD1   . ASP D 2 443 ? 208.122 251.377 234.477 1.00 100.99 ? 455 ASP A OD1   1 
ATOM 3638 O OD2   . ASP D 2 443 ? 209.392 250.671 232.832 1.00 100.99 ? 455 ASP A OD2   1 
ATOM 3639 N N     . VAL D 2 444 ? 206.990 254.918 232.020 1.00 92.31  ? 456 VAL A N     1 
ATOM 3640 C CA    . VAL D 2 444 ? 205.792 255.026 231.205 1.00 92.31  ? 456 VAL A CA    1 
ATOM 3641 C C     . VAL D 2 444 ? 206.117 254.512 229.813 1.00 92.31  ? 456 VAL A C     1 
ATOM 3642 O O     . VAL D 2 444 ? 206.812 255.182 229.042 1.00 92.31  ? 456 VAL A O     1 
ATOM 3643 C CB    . VAL D 2 444 ? 205.278 256.472 231.159 1.00 92.31  ? 456 VAL A CB    1 
ATOM 3644 C CG1   . VAL D 2 444 ? 204.001 256.557 230.337 1.00 92.31  ? 456 VAL A CG1   1 
ATOM 3645 C CG2   . VAL D 2 444 ? 205.048 257.000 232.563 1.00 92.31  ? 456 VAL A CG2   1 
ATOM 3646 N N     . SER D 2 445 ? 205.612 253.331 229.490 1.00 88.04  ? 457 SER A N     1 
ATOM 3647 C CA    . SER D 2 445 ? 205.734 252.774 228.155 1.00 88.04  ? 457 SER A CA    1 
ATOM 3648 C C     . SER D 2 445 ? 204.571 253.251 227.297 1.00 88.04  ? 457 SER A C     1 
ATOM 3649 O O     . SER D 2 445 ? 203.532 253.678 227.805 1.00 88.04  ? 457 SER A O     1 
ATOM 3650 C CB    . SER D 2 445 ? 205.766 251.246 228.201 1.00 88.04  ? 457 SER A CB    1 
ATOM 3651 O OG    . SER D 2 445 ? 204.678 250.746 228.958 1.00 88.04  ? 457 SER A OG    1 
ATOM 3652 N N     . PHE D 2 446 ? 204.763 253.172 225.980 1.00 82.76  ? 458 PHE A N     1 
ATOM 3653 C CA    . PHE D 2 446 ? 203.758 253.608 225.010 1.00 82.76  ? 458 PHE A CA    1 
ATOM 3654 C C     . PHE D 2 446 ? 203.383 255.072 225.239 1.00 82.76  ? 458 PHE A C     1 
ATOM 3655 O O     . PHE D 2 446 ? 202.207 255.436 225.296 1.00 82.76  ? 458 PHE A O     1 
ATOM 3656 C CB    . PHE D 2 446 ? 202.523 252.706 225.062 1.00 82.76  ? 458 PHE A CB    1 
ATOM 3657 C CG    . PHE D 2 446 ? 202.847 251.241 225.122 1.00 82.76  ? 458 PHE A CG    1 
ATOM 3658 C CD1   . PHE D 2 446 ? 203.660 250.657 224.167 1.00 82.76  ? 458 PHE A CD1   1 
ATOM 3659 C CD2   . PHE D 2 446 ? 202.346 250.450 226.142 1.00 82.76  ? 458 PHE A CD2   1 
ATOM 3660 C CE1   . PHE D 2 446 ? 203.962 249.309 224.224 1.00 82.76  ? 458 PHE A CE1   1 
ATOM 3661 C CE2   . PHE D 2 446 ? 202.645 249.103 226.204 1.00 82.76  ? 458 PHE A CE2   1 
ATOM 3662 C CZ    . PHE D 2 446 ? 203.454 248.533 225.244 1.00 82.76  ? 458 PHE A CZ    1 
ATOM 3663 N N     . GLN D 2 447 ? 204.407 255.912 225.387 1.00 84.37  ? 459 GLN A N     1 
ATOM 3664 C CA    . GLN D 2 447 ? 204.189 257.329 225.648 1.00 84.37  ? 459 GLN A CA    1 
ATOM 3665 C C     . GLN D 2 447 ? 203.408 257.969 224.508 1.00 84.37  ? 459 GLN A C     1 
ATOM 3666 O O     . GLN D 2 447 ? 203.742 257.795 223.333 1.00 84.37  ? 459 GLN A O     1 
ATOM 3667 C CB    . GLN D 2 447 ? 205.528 258.042 225.834 1.00 84.37  ? 459 GLN A CB    1 
ATOM 3668 C CG    . GLN D 2 447 ? 205.407 259.453 226.379 1.00 84.37  ? 459 GLN A CG    1 
ATOM 3669 C CD    . GLN D 2 447 ? 205.038 259.481 227.846 1.00 84.37  ? 459 GLN A CD    1 
ATOM 3670 O OE1   . GLN D 2 447 ? 205.628 258.770 228.659 1.00 84.37  ? 459 GLN A OE1   1 
ATOM 3671 N NE2   . GLN D 2 447 ? 204.057 260.305 228.194 1.00 84.37  ? 459 GLN A NE2   1 
ATOM 3672 N N     . GLY D 2 448 ? 202.361 258.710 224.862 1.00 86.61  ? 460 GLY A N     1 
ATOM 3673 C CA    . GLY D 2 448 ? 201.507 259.340 223.881 1.00 86.61  ? 460 GLY A CA    1 
ATOM 3674 C C     . GLY D 2 448 ? 200.502 258.420 223.226 1.00 86.61  ? 460 GLY A C     1 
ATOM 3675 O O     . GLY D 2 448 ? 199.752 258.872 222.351 1.00 86.61  ? 460 GLY A O     1 
ATOM 3676 N N     . ARG D 2 449 ? 200.461 257.149 223.616 1.00 82.62  ? 461 ARG A N     1 
ATOM 3677 C CA    . ARG D 2 449 ? 199.564 256.161 223.024 1.00 82.62  ? 461 ARG A CA    1 
ATOM 3678 C C     . ARG D 2 449 ? 198.448 255.899 224.029 1.00 82.62  ? 461 ARG A C     1 
ATOM 3679 O O     . ARG D 2 449 ? 198.660 255.238 225.047 1.00 82.62  ? 461 ARG A O     1 
ATOM 3680 C CB    . ARG D 2 449 ? 200.323 254.883 222.687 1.00 82.62  ? 461 ARG A CB    1 
ATOM 3681 C CG    . ARG D 2 449 ? 201.533 255.087 221.787 1.00 82.62  ? 461 ARG A CG    1 
ATOM 3682 C CD    . ARG D 2 449 ? 202.302 253.786 221.615 1.00 82.62  ? 461 ARG A CD    1 
ATOM 3683 N NE    . ARG D 2 449 ? 203.572 253.971 220.924 1.00 82.62  ? 461 ARG A NE    1 
ATOM 3684 C CZ    . ARG D 2 449 ? 203.718 253.984 219.606 1.00 82.62  ? 461 ARG A CZ    1 
ATOM 3685 N NH1   . ARG D 2 449 ? 202.689 253.807 218.796 1.00 82.62  ? 461 ARG A NH1   1 
ATOM 3686 N NH2   . ARG D 2 449 ? 204.929 254.171 219.089 1.00 82.62  ? 461 ARG A NH2   1 
ATOM 3687 N N     . GLY D 2 450 ? 197.260 256.426 223.749 1.00 79.95  ? 462 GLY A N     1 
ATOM 3688 C CA    . GLY D 2 450 ? 196.114 256.263 224.614 1.00 79.95  ? 462 GLY A CA    1 
ATOM 3689 C C     . GLY D 2 450 ? 195.057 255.352 224.023 1.00 79.95  ? 462 GLY A C     1 
ATOM 3690 O O     . GLY D 2 450 ? 195.307 254.574 223.096 1.00 79.95  ? 462 GLY A O     1 
ATOM 3691 N N     . VAL D 2 451 ? 193.853 255.451 224.577 1.00 78.95  ? 463 VAL A N     1 
ATOM 3692 C CA    . VAL D 2 451 ? 192.695 254.739 224.061 1.00 78.95  ? 463 VAL A CA    1 
ATOM 3693 C C     . VAL D 2 451 ? 191.909 255.695 223.177 1.00 78.95  ? 463 VAL A C     1 
ATOM 3694 O O     . VAL D 2 451 ? 192.130 256.909 223.177 1.00 78.95  ? 463 VAL A O     1 
ATOM 3695 C CB    . VAL D 2 451 ? 191.805 254.174 225.186 1.00 78.95  ? 463 VAL A CB    1 
ATOM 3696 C CG1   . VAL D 2 451 ? 192.592 253.205 226.049 1.00 78.95  ? 463 VAL A CG1   1 
ATOM 3697 C CG2   . VAL D 2 451 ? 191.235 255.302 226.025 1.00 78.95  ? 463 VAL A CG2   1 
ATOM 3698 N N     . PHE D 2 452 ? 190.980 255.136 222.409 1.00 80.15  ? 464 PHE A N     1 
ATOM 3699 C CA    . PHE D 2 452 ? 190.202 255.915 221.459 1.00 80.15  ? 464 PHE A CA    1 
ATOM 3700 C C     . PHE D 2 452 ? 188.722 255.596 221.598 1.00 80.15  ? 464 PHE A C     1 
ATOM 3701 O O     . PHE D 2 452 ? 188.338 254.488 221.981 1.00 80.15  ? 464 PHE A O     1 
ATOM 3702 C CB    . PHE D 2 452 ? 190.664 255.657 220.021 1.00 80.15  ? 464 PHE A CB    1 
ATOM 3703 C CG    . PHE D 2 452 ? 192.141 255.425 219.897 1.00 80.15  ? 464 PHE A CG    1 
ATOM 3704 C CD1   . PHE D 2 452 ? 193.026 256.488 219.943 1.00 80.15  ? 464 PHE A CD1   1 
ATOM 3705 C CD2   . PHE D 2 452 ? 192.645 254.146 219.741 1.00 80.15  ? 464 PHE A CD2   1 
ATOM 3706 C CE1   . PHE D 2 452 ? 194.386 256.280 219.833 1.00 80.15  ? 464 PHE A CE1   1 
ATOM 3707 C CE2   . PHE D 2 452 ? 194.005 253.932 219.630 1.00 80.15  ? 464 PHE A CE2   1 
ATOM 3708 C CZ    . PHE D 2 452 ? 194.875 255.001 219.676 1.00 80.15  ? 464 PHE A CZ    1 
ATOM 3709 N N     . GLU D 2 453 ? 187.898 256.594 221.295 1.00 86.42  ? 465 GLU A N     1 
ATOM 3710 C CA    . GLU D 2 453 ? 186.454 256.425 221.313 1.00 86.42  ? 465 GLU A CA    1 
ATOM 3711 C C     . GLU D 2 453 ? 186.021 255.523 220.160 1.00 86.42  ? 465 GLU A C     1 
ATOM 3712 O O     . GLU D 2 453 ? 186.662 255.476 219.107 1.00 86.42  ? 465 GLU A O     1 
ATOM 3713 C CB    . GLU D 2 453 ? 185.777 257.799 221.230 1.00 86.42  ? 465 GLU A CB    1 
ATOM 3714 C CG    . GLU D 2 453 ? 185.959 258.723 222.426 1.00 86.42  ? 465 GLU A CG    1 
ATOM 3715 C CD    . GLU D 2 453 ? 185.317 260.080 222.222 1.00 86.42  ? 465 GLU A CD    1 
ATOM 3716 O OE1   . GLU D 2 453 ? 184.894 260.376 221.086 1.00 86.42  ? 465 GLU A OE1   1 
ATOM 3717 O OE2   . GLU D 2 453 ? 185.237 260.854 223.200 1.00 86.42  ? 465 GLU A OE2   1 
ATOM 3718 N N     . LEU D 2 454 ? 184.933 254.777 220.381 1.00 81.94  ? 466 LEU A N     1 
ATOM 3719 C CA    . LEU D 2 454 ? 184.420 253.887 219.343 1.00 81.94  ? 466 LEU A CA    1 
ATOM 3720 C C     . LEU D 2 454 ? 184.090 254.643 218.062 1.00 81.94  ? 466 LEU A C     1 
ATOM 3721 O O     . LEU D 2 454 ? 184.269 254.106 216.963 1.00 81.94  ? 466 LEU A O     1 
ATOM 3722 C CB    . LEU D 2 454 ? 183.184 253.145 219.850 1.00 81.94  ? 466 LEU A CB    1 
ATOM 3723 C CG    . LEU D 2 454 ? 183.389 251.697 220.297 1.00 81.94  ? 466 LEU A CG    1 
ATOM 3724 C CD1   . LEU D 2 454 ? 183.640 250.795 219.099 1.00 81.94  ? 466 LEU A CD1   1 
ATOM 3725 C CD2   . LEU D 2 454 ? 184.526 251.597 221.300 1.00 81.94  ? 466 LEU A CD2   1 
ATOM 3726 N N     . SER D 2 455 ? 183.608 255.882 218.179 1.00 86.67  ? 467 SER A N     1 
ATOM 3727 C CA    . SER D 2 455 ? 183.361 256.691 216.991 1.00 86.67  ? 467 SER A CA    1 
ATOM 3728 C C     . SER D 2 455 ? 184.660 257.080 216.298 1.00 86.67  ? 467 SER A C     1 
ATOM 3729 O O     . SER D 2 455 ? 184.657 257.372 215.097 1.00 86.67  ? 467 SER A O     1 
ATOM 3730 C CB    . SER D 2 455 ? 182.563 257.940 217.363 1.00 86.67  ? 467 SER A CB    1 
ATOM 3731 O OG    . SER D 2 455 ? 181.395 257.601 218.089 1.00 86.67  ? 467 SER A OG    1 
ATOM 3732 N N     . ASP D 2 456 ? 185.773 257.089 217.032 1.00 87.71  ? 468 ASP A N     1 
ATOM 3733 C CA    . ASP D 2 456 ? 187.085 257.401 216.468 1.00 87.71  ? 468 ASP A CA    1 
ATOM 3734 C C     . ASP D 2 456 ? 187.657 256.126 215.855 1.00 87.71  ? 468 ASP A C     1 
ATOM 3735 O O     . ASP D 2 456 ? 188.463 255.408 216.452 1.00 87.71  ? 468 ASP A O     1 
ATOM 3736 C CB    . ASP D 2 456 ? 188.005 257.977 217.538 1.00 87.71  ? 468 ASP A CB    1 
ATOM 3737 C CG    . ASP D 2 456 ? 189.194 258.703 216.952 1.00 87.71  ? 468 ASP A CG    1 
ATOM 3738 O OD1   . ASP D 2 456 ? 189.525 258.445 215.777 1.00 87.71  ? 468 ASP A OD1   1 
ATOM 3739 O OD2   . ASP D 2 456 ? 189.801 259.530 217.665 1.00 87.71  ? 468 ASP A OD2   1 
ATOM 3740 N N     . GLU D 2 457 ? 187.223 255.844 214.627 1.00 90.21  ? 469 GLU A N     1 
ATOM 3741 C CA    . GLU D 2 457 ? 187.598 254.609 213.951 1.00 90.21  ? 469 GLU A CA    1 
ATOM 3742 C C     . GLU D 2 457 ? 189.021 254.620 213.406 1.00 90.21  ? 469 GLU A C     1 
ATOM 3743 O O     . GLU D 2 457 ? 189.563 253.544 213.132 1.00 90.21  ? 469 GLU A O     1 
ATOM 3744 C CB    . GLU D 2 457 ? 186.608 254.313 212.816 1.00 90.21  ? 469 GLU A CB    1 
ATOM 3745 C CG    . GLU D 2 457 ? 185.154 253.964 213.208 1.00 90.21  ? 469 GLU A CG    1 
ATOM 3746 C CD    . GLU D 2 457 ? 184.177 253.744 212.046 1.00 90.21  ? 469 GLU A CD    1 
ATOM 3747 O OE1   . GLU D 2 457 ? 184.572 254.048 210.901 1.00 90.21  ? 469 GLU A OE1   1 
ATOM 3748 O OE2   . GLU D 2 457 ? 183.057 253.226 212.238 1.00 90.21  ? 469 GLU A OE2   1 
ATOM 3749 N N     . LYS D 2 458 ? 189.636 255.789 213.238 1.00 87.66  ? 470 LYS A N     1 
ATOM 3750 C CA    . LYS D 2 458 ? 190.998 255.879 212.728 1.00 87.66  ? 470 LYS A CA    1 
ATOM 3751 C C     . LYS D 2 458 ? 191.980 256.319 213.815 1.00 87.66  ? 470 LYS A C     1 
ATOM 3752 O O     . LYS D 2 458 ? 193.191 256.369 213.569 1.00 87.66  ? 470 LYS A O     1 
ATOM 3753 C CB    . LYS D 2 458 ? 191.010 256.796 211.486 1.00 87.66  ? 470 LYS A CB    1 
ATOM 3754 C CG    . LYS D 2 458 ? 190.243 256.393 210.216 1.00 87.66  ? 470 LYS A CG    1 
ATOM 3755 C CD    . LYS D 2 458 ? 190.820 255.187 209.497 1.00 87.66  ? 470 LYS A CD    1 
ATOM 3756 C CE    . LYS D 2 458 ? 190.065 254.918 208.205 1.00 87.66  ? 470 LYS A CE    1 
ATOM 3757 N NZ    . LYS D 2 458 ? 188.694 254.392 208.449 1.00 87.66  ? 470 LYS A NZ    1 
ATOM 3758 N N     . ALA D 2 459 ? 191.482 256.564 215.033 1.00 84.56  ? 471 ALA A N     1 
ATOM 3759 C CA    . ALA D 2 459 ? 192.301 256.926 216.195 1.00 84.56  ? 471 ALA A CA    1 
ATOM 3760 C C     . ALA D 2 459 ? 192.942 258.303 216.033 1.00 84.56  ? 471 ALA A C     1 
ATOM 3761 O O     . ALA D 2 459 ? 194.162 258.456 216.123 1.00 84.56  ? 471 ALA A O     1 
ATOM 3762 C CB    . ALA D 2 459 ? 193.363 255.861 216.488 1.00 84.56  ? 471 ALA A CB    1 
ATOM 3763 N N     . THR D 2 460 ? 192.109 259.318 215.786 1.00 88.26  ? 472 THR A N     1 
ATOM 3764 C CA    . THR D 2 460 ? 192.615 260.686 215.721 1.00 88.26  ? 472 THR A CA    1 
ATOM 3765 C C     . THR D 2 460 ? 193.118 261.161 217.079 1.00 88.26  ? 472 THR A C     1 
ATOM 3766 O O     . THR D 2 460 ? 194.240 261.669 217.187 1.00 88.26  ? 472 THR A O     1 
ATOM 3767 C CB    . THR D 2 460 ? 191.531 261.638 215.211 1.00 88.26  ? 472 THR A CB    1 
ATOM 3768 O OG1   . THR D 2 460 ? 190.765 262.127 216.319 1.00 88.26  ? 472 THR A OG1   1 
ATOM 3769 C CG2   . THR D 2 460 ? 190.604 260.941 214.234 1.00 88.26  ? 472 THR A CG2   1 
ATOM 3770 N N     . SER D 2 461 ? 192.307 261.007 218.123 1.00 82.67  ? 473 SER A N     1 
ATOM 3771 C CA    . SER D 2 461 ? 192.589 261.603 219.430 1.00 82.67  ? 473 SER A CA    1 
ATOM 3772 C C     . SER D 2 461 ? 192.706 260.534 220.506 1.00 82.67  ? 473 SER A C     1 
ATOM 3773 O O     . SER D 2 461 ? 191.683 259.995 220.964 1.00 82.67  ? 473 SER A O     1 
ATOM 3774 C CB    . SER D 2 461 ? 191.502 262.610 219.800 1.00 82.67  ? 473 SER A CB    1 
ATOM 3775 O OG    . SER D 2 461 ? 190.249 261.969 219.962 1.00 82.67  ? 473 SER A OG    1 
ATOM 3776 N N     . PRO D 2 462 ? 193.915 260.192 220.941 1.00 78.68  ? 474 PRO A N     1 
ATOM 3777 C CA    . PRO D 2 462 ? 194.060 259.275 222.074 1.00 78.68  ? 474 PRO A CA    1 
ATOM 3778 C C     . PRO D 2 462 ? 193.605 259.923 223.373 1.00 78.68  ? 474 PRO A C     1 
ATOM 3779 O O     . PRO D 2 462 ? 193.622 261.145 223.535 1.00 78.68  ? 474 PRO A O     1 
ATOM 3780 C CB    . PRO D 2 462 ? 195.564 258.970 222.105 1.00 78.68  ? 474 PRO A CB    1 
ATOM 3781 C CG    . PRO D 2 462 ? 196.105 259.472 220.797 1.00 78.68  ? 474 PRO A CG    1 
ATOM 3782 C CD    . PRO D 2 462 ? 195.216 260.596 220.386 1.00 78.68  ? 474 PRO A CD    1 
ATOM 3783 N N     . ILE D 2 463 ? 193.191 259.075 224.311 1.00 76.00  ? 475 ILE A N     1 
ATOM 3784 C CA    . ILE D 2 463 ? 192.762 259.507 225.634 1.00 76.00  ? 475 ILE A CA    1 
ATOM 3785 C C     . ILE D 2 463 ? 193.777 259.020 226.657 1.00 76.00  ? 475 ILE A C     1 
ATOM 3786 O O     . ILE D 2 463 ? 194.088 257.825 226.719 1.00 76.00  ? 475 ILE A O     1 
ATOM 3787 C CB    . ILE D 2 463 ? 191.347 258.996 225.977 1.00 76.00  ? 475 ILE A CB    1 
ATOM 3788 C CG1   . ILE D 2 463 ? 190.296 259.742 225.153 1.00 76.00  ? 475 ILE A CG1   1 
ATOM 3789 C CG2   . ILE D 2 463 ? 191.067 259.148 227.462 1.00 76.00  ? 475 ILE A CG2   1 
ATOM 3790 C CD1   . ILE D 2 463 ? 189.798 258.978 223.948 1.00 76.00  ? 475 ILE A CD1   1 
ATOM 3791 N N     . VAL D 2 464 ? 194.290 259.947 227.457 1.00 80.80  ? 476 VAL A N     1 
ATOM 3792 C CA    . VAL D 2 464 ? 195.324 259.652 228.443 1.00 80.80  ? 476 VAL A CA    1 
ATOM 3793 C C     . VAL D 2 464 ? 194.635 259.238 229.741 1.00 80.80  ? 476 VAL A C     1 
ATOM 3794 O O     . VAL D 2 464 ? 193.910 260.058 230.328 1.00 80.80  ? 476 VAL A O     1 
ATOM 3795 C CB    . VAL D 2 464 ? 196.238 260.860 228.674 1.00 80.80  ? 476 VAL A CB    1 
ATOM 3796 C CG1   . VAL D 2 464 ? 197.245 260.565 229.776 1.00 80.80  ? 476 VAL A CG1   1 
ATOM 3797 C CG2   . VAL D 2 464 ? 196.938 261.255 227.381 1.00 80.80  ? 476 VAL A CG2   1 
ATOM 3798 N N     . PRO D 2 465 ? 194.823 258.012 230.216 1.00 74.79  ? 477 PRO A N     1 
ATOM 3799 C CA    . PRO D 2 465 ? 194.231 257.616 231.495 1.00 74.79  ? 477 PRO A CA    1 
ATOM 3800 C C     . PRO D 2 465 ? 195.030 258.147 232.674 1.00 74.79  ? 477 PRO A C     1 
ATOM 3801 O O     . PRO D 2 465 ? 196.252 258.301 232.616 1.00 74.79  ? 477 PRO A O     1 
ATOM 3802 C CB    . PRO D 2 465 ? 194.279 256.086 231.442 1.00 74.79  ? 477 PRO A CB    1 
ATOM 3803 C CG    . PRO D 2 465 ? 195.474 255.798 230.608 1.00 74.79  ? 477 PRO A CG    1 
ATOM 3804 C CD    . PRO D 2 465 ? 195.552 256.902 229.578 1.00 74.79  ? 477 PRO A CD    1 
ATOM 3805 N N     . SER D 2 466 ? 194.314 258.425 233.758 1.00 73.01  ? 478 SER A N     1 
ATOM 3806 C CA    . SER D 2 466 ? 194.909 258.918 234.993 1.00 73.01  ? 478 SER A CA    1 
ATOM 3807 C C     . SER D 2 466 ? 194.749 257.866 236.080 1.00 73.01  ? 478 SER A C     1 
ATOM 3808 O O     . SER D 2 466 ? 193.632 257.417 236.356 1.00 73.01  ? 478 SER A O     1 
ATOM 3809 C CB    . SER D 2 466 ? 194.261 260.234 235.427 1.00 73.01  ? 478 SER A CB    1 
ATOM 3810 O OG    . SER D 2 466 ? 193.301 260.015 236.445 1.00 73.01  ? 478 SER A OG    1 
ATOM 3811 N N     . PHE D 2 467 ? 195.862 257.479 236.694 1.00 70.21  ? 479 PHE A N     1 
ATOM 3812 C CA    . PHE D 2 467 ? 195.840 256.466 237.741 1.00 70.21  ? 479 PHE A CA    1 
ATOM 3813 C C     . PHE D 2 467 ? 196.510 256.980 239.011 1.00 70.21  ? 479 PHE A C     1 
ATOM 3814 O O     . PHE D 2 467 ? 197.007 256.199 239.822 1.00 70.21  ? 479 PHE A O     1 
ATOM 3815 C CB    . PHE D 2 467 ? 196.526 255.185 237.262 1.00 70.21  ? 479 PHE A CB    1 
ATOM 3816 C CG    . PHE D 2 467 ? 195.806 254.495 236.139 1.00 70.21  ? 479 PHE A CG    1 
ATOM 3817 C CD1   . PHE D 2 467 ? 194.439 254.286 236.199 1.00 70.21  ? 479 PHE A CD1   1 
ATOM 3818 C CD2   . PHE D 2 467 ? 196.497 254.052 235.024 1.00 70.21  ? 479 PHE A CD2   1 
ATOM 3819 C CE1   . PHE D 2 467 ? 193.774 253.651 235.166 1.00 70.21  ? 479 PHE A CE1   1 
ATOM 3820 C CE2   . PHE D 2 467 ? 195.838 253.416 233.989 1.00 70.21  ? 479 PHE A CE2   1 
ATOM 3821 C CZ    . PHE D 2 467 ? 194.476 253.215 234.061 1.00 70.21  ? 479 PHE A CZ    1 
ATOM 3822 N N     . GLU D 2 472 ? 194.919 250.615 244.036 1.00 68.78  ? 484 GLU A N     1 
ATOM 3823 C CA    . GLU D 2 472 ? 193.906 249.578 243.882 1.00 68.78  ? 484 GLU A CA    1 
ATOM 3824 C C     . GLU D 2 472 ? 194.525 248.286 243.361 1.00 68.78  ? 484 GLU A C     1 
ATOM 3825 O O     . GLU D 2 472 ? 195.718 248.236 243.064 1.00 68.78  ? 484 GLU A O     1 
ATOM 3826 C CB    . GLU D 2 472 ? 192.797 250.045 242.937 1.00 68.78  ? 484 GLU A CB    1 
ATOM 3827 C CG    . GLU D 2 472 ? 192.378 251.491 243.136 1.00 68.78  ? 484 GLU A CG    1 
ATOM 3828 C CD    . GLU D 2 472 ? 193.092 252.437 242.192 1.00 68.78  ? 484 GLU A CD    1 
ATOM 3829 O OE1   . GLU D 2 472 ? 193.117 252.157 240.975 1.00 68.78  ? 484 GLU A OE1   1 
ATOM 3830 O OE2   . GLU D 2 472 ? 193.628 253.460 242.666 1.00 68.78  ? 484 GLU A OE2   1 
ATOM 3831 N N     . GLY D 2 473 ? 193.707 247.242 243.259 1.00 68.75  ? 485 GLY A N     1 
ATOM 3832 C CA    . GLY D 2 473 ? 194.184 245.990 242.709 1.00 68.75  ? 485 GLY A CA    1 
ATOM 3833 C C     . GLY D 2 473 ? 194.559 246.125 241.246 1.00 68.75  ? 485 GLY A C     1 
ATOM 3834 O O     . GLY D 2 473 ? 193.950 246.877 240.485 1.00 68.75  ? 485 GLY A O     1 
ATOM 3835 N N     . SER D 2 474 ? 195.588 245.380 240.848 1.00 70.20  ? 486 SER A N     1 
ATOM 3836 C CA    . SER D 2 474 ? 196.106 245.485 239.493 1.00 70.20  ? 486 SER A CA    1 
ATOM 3837 C C     . SER D 2 474 ? 196.461 244.150 238.855 1.00 70.20  ? 486 SER A C     1 
ATOM 3838 O O     . SER D 2 474 ? 196.950 244.147 237.722 1.00 70.20  ? 486 SER A O     1 
ATOM 3839 C CB    . SER D 2 474 ? 197.343 246.397 239.469 1.00 70.20  ? 486 SER A CB    1 
ATOM 3840 O OG    . SER D 2 474 ? 197.929 246.427 238.179 1.00 70.20  ? 486 SER A OG    1 
ATOM 3841 N N     . TYR D 2 475 ? 196.244 243.025 239.532 1.00 69.28  ? 487 TYR A N     1 
ATOM 3842 C CA    . TYR D 2 475 ? 196.642 241.722 239.018 1.00 69.28  ? 487 TYR A CA    1 
ATOM 3843 C C     . TYR D 2 475 ? 195.417 240.822 238.987 1.00 69.28  ? 487 TYR A C     1 
ATOM 3844 O O     . TYR D 2 475 ? 194.705 240.707 239.990 1.00 69.28  ? 487 TYR A O     1 
ATOM 3845 C CB    . TYR D 2 475 ? 197.738 241.110 239.888 1.00 69.28  ? 487 TYR A CB    1 
ATOM 3846 C CG    . TYR D 2 475 ? 198.887 242.057 240.116 1.00 69.28  ? 487 TYR A CG    1 
ATOM 3847 C CD1   . TYR D 2 475 ? 199.542 242.655 239.051 1.00 69.28  ? 487 TYR A CD1   1 
ATOM 3848 C CD2   . TYR D 2 475 ? 199.265 242.412 241.402 1.00 69.28  ? 487 TYR A CD2   1 
ATOM 3849 C CE1   . TYR D 2 475 ? 200.570 243.550 239.264 1.00 69.28  ? 487 TYR A CE1   1 
ATOM 3850 C CE2   . TYR D 2 475 ? 200.297 243.292 241.625 1.00 69.28  ? 487 TYR A CE2   1 
ATOM 3851 C CZ    . TYR D 2 475 ? 200.947 243.859 240.554 1.00 69.28  ? 487 TYR A CZ    1 
ATOM 3852 O OH    . TYR D 2 475 ? 201.975 244.741 240.779 1.00 69.28  ? 487 TYR A OH    1 
ATOM 3853 N N     . PHE D 2 476 ? 195.170 240.190 237.839 1.00 65.88  ? 488 PHE A N     1 
ATOM 3854 C CA    . PHE D 2 476 ? 194.002 239.324 237.720 1.00 65.88  ? 488 PHE A CA    1 
ATOM 3855 C C     . PHE D 2 476 ? 194.142 238.091 238.603 1.00 65.88  ? 488 PHE A C     1 
ATOM 3856 O O     . PHE D 2 476 ? 193.230 237.755 239.367 1.00 65.88  ? 488 PHE A O     1 
ATOM 3857 C CB    . PHE D 2 476 ? 193.790 238.924 236.260 1.00 65.88  ? 488 PHE A CB    1 
ATOM 3858 C CG    . PHE D 2 476 ? 192.519 238.164 236.024 1.00 65.88  ? 488 PHE A CG    1 
ATOM 3859 C CD1   . PHE D 2 476 ? 191.294 238.730 236.327 1.00 65.88  ? 488 PHE A CD1   1 
ATOM 3860 C CD2   . PHE D 2 476 ? 192.547 236.886 235.499 1.00 65.88  ? 488 PHE A CD2   1 
ATOM 3861 C CE1   . PHE D 2 476 ? 190.121 238.035 236.116 1.00 65.88  ? 488 PHE A CE1   1 
ATOM 3862 C CE2   . PHE D 2 476 ? 191.377 236.186 235.283 1.00 65.88  ? 488 PHE A CE2   1 
ATOM 3863 C CZ    . PHE D 2 476 ? 190.163 236.760 235.594 1.00 65.88  ? 488 PHE A CZ    1 
ATOM 3864 N N     . PHE D 2 477 ? 195.278 237.409 238.516 1.00 63.02  ? 489 PHE A N     1 
ATOM 3865 C CA    . PHE D 2 477 ? 195.534 236.218 239.325 1.00 63.02  ? 489 PHE A CA    1 
ATOM 3866 C C     . PHE D 2 477 ? 196.277 236.567 240.612 1.00 63.02  ? 489 PHE A C     1 
ATOM 3867 O O     . PHE D 2 477 ? 197.325 236.002 240.921 1.00 63.02  ? 489 PHE A O     1 
ATOM 3868 C CB    . PHE D 2 477 ? 196.308 235.193 238.506 1.00 63.02  ? 489 PHE A CB    1 
ATOM 3869 C CG    . PHE D 2 477 ? 195.545 234.656 237.329 1.00 63.02  ? 489 PHE A CG    1 
ATOM 3870 C CD1   . PHE D 2 477 ? 194.221 234.278 237.458 1.00 63.02  ? 489 PHE A CD1   1 
ATOM 3871 C CD2   . PHE D 2 477 ? 196.154 234.527 236.093 1.00 63.02  ? 489 PHE A CD2   1 
ATOM 3872 C CE1   . PHE D 2 477 ? 193.520 233.776 236.381 1.00 63.02  ? 489 PHE A CE1   1 
ATOM 3873 C CE2   . PHE D 2 477 ? 195.455 234.030 235.011 1.00 63.02  ? 489 PHE A CE2   1 
ATOM 3874 C CZ    . PHE D 2 477 ? 194.136 233.656 235.155 1.00 63.02  ? 489 PHE A CZ    1 
ATOM 3875 N N     . GLY D 2 478 ? 195.728 237.505 241.377 1.00 55.59  ? 490 GLY A N     1 
ATOM 3876 C CA    . GLY D 2 478 ? 196.358 237.945 242.608 1.00 55.59  ? 490 GLY A CA    1 
ATOM 3877 C C     . GLY D 2 478 ? 195.462 237.845 243.826 1.00 55.59  ? 490 GLY A C     1 
ATOM 3878 O O     . GLY D 2 478 ? 195.936 237.892 244.962 1.00 55.59  ? 490 GLY A O     1 
# 
